id sid tid token lemma pos cord-300061-l2pfl776 1 1 key key NN cord-300061-l2pfl776 1 2 : : : cord-300061-l2pfl776 2 1 cord-300061-l2pfl776 cord-300061-l2pfl776 NNP cord-300061-l2pfl776 2 2 authors author NNS cord-300061-l2pfl776 2 3 : : : cord-300061-l2pfl776 2 4 Zhang Zhang NNP cord-300061-l2pfl776 2 5 , , , cord-300061-l2pfl776 3 1 Ren Ren NNP cord-300061-l2pfl776 3 2 title title NN cord-300061-l2pfl776 3 3 : : : cord-300061-l2pfl776 4 1 A a DT cord-300061-l2pfl776 4 2 rebuttal rebuttal NN cord-300061-l2pfl776 4 3 to to IN cord-300061-l2pfl776 4 4 the the DT cord-300061-l2pfl776 4 5 comments comment NNS cord-300061-l2pfl776 4 6 on on IN cord-300061-l2pfl776 4 7 the the DT cord-300061-l2pfl776 4 8 genome genome NN cord-300061-l2pfl776 4 9 order order NN cord-300061-l2pfl776 4 10 index index NN cord-300061-l2pfl776 4 11 and and CC cord-300061-l2pfl776 4 12 the the DT cord-300061-l2pfl776 4 13 Z z NN cord-300061-l2pfl776 4 14 - - HYPH cord-300061-l2pfl776 4 15 curve curve NN cord-300061-l2pfl776 4 16 date date NN cord-300061-l2pfl776 4 17 : : : cord-300061-l2pfl776 4 18 2011 2011 CD cord-300061-l2pfl776 4 19 - - SYM cord-300061-l2pfl776 4 20 02 02 CD cord-300061-l2pfl776 4 21 - - SYM cord-300061-l2pfl776 4 22 16 16 CD cord-300061-l2pfl776 4 23 journal journal NN cord-300061-l2pfl776 4 24 : : : cord-300061-l2pfl776 5 1 Biol Biol NNP cord-300061-l2pfl776 5 2 Direct Direct NNP cord-300061-l2pfl776 5 3 DOI DOI NNP cord-300061-l2pfl776 5 4 : : : cord-300061-l2pfl776 5 5 10.1186/1745 10.1186/1745 CD cord-300061-l2pfl776 5 6 - - HYPH cord-300061-l2pfl776 5 7 6150 6150 CD cord-300061-l2pfl776 5 8 - - HYPH cord-300061-l2pfl776 5 9 6 6 CD cord-300061-l2pfl776 5 10 - - SYM cord-300061-l2pfl776 5 11 10 10 CD cord-300061-l2pfl776 5 12 sha sha NN cord-300061-l2pfl776 5 13 : : : cord-300061-l2pfl776 5 14 5cd3d3edd1b68bce986c6b9e6bfa9720efd041e3 5cd3d3edd1b68bce986c6b9e6bfa9720efd041e3 CD cord-300061-l2pfl776 5 15 doc_id doc_id NNPS cord-300061-l2pfl776 5 16 : : : cord-300061-l2pfl776 5 17 300061 300061 CD cord-300061-l2pfl776 5 18 cord_uid cord_uid NN cord-300061-l2pfl776 5 19 : : : cord-300061-l2pfl776 6 1 l2pfl776 l2pfl776 LS cord-300061-l2pfl776 6 2 BACKGROUND background NN cord-300061-l2pfl776 6 3 : : : cord-300061-l2pfl776 7 1 Elhaik Elhaik NNP cord-300061-l2pfl776 7 2 , , , cord-300061-l2pfl776 7 3 Graur Graur NNP cord-300061-l2pfl776 7 4 and and CC cord-300061-l2pfl776 7 5 Josic Josic NNP cord-300061-l2pfl776 7 6 recently recently RB cord-300061-l2pfl776 7 7 commented comment VBD cord-300061-l2pfl776 7 8 on on IN cord-300061-l2pfl776 7 9 the the DT cord-300061-l2pfl776 7 10 genome genome NN cord-300061-l2pfl776 7 11 order order NN cord-300061-l2pfl776 7 12 index index NN cord-300061-l2pfl776 7 13 ( ( -LRB- cord-300061-l2pfl776 7 14 S S NNP cord-300061-l2pfl776 7 15 ) ) -RRB- cord-300061-l2pfl776 7 16 and and CC cord-300061-l2pfl776 7 17 the the DT cord-300061-l2pfl776 7 18 Z z NN cord-300061-l2pfl776 7 19 - - HYPH cord-300061-l2pfl776 7 20 curve curve NN cord-300061-l2pfl776 8 1 ( ( -LRB- cord-300061-l2pfl776 8 2 Elhaik Elhaik NNP cord-300061-l2pfl776 8 3 et et NNP cord-300061-l2pfl776 8 4 al al NNP cord-300061-l2pfl776 8 5 . . . cord-300061-l2pfl776 9 1 Biol Biol NNP cord-300061-l2pfl776 9 2 Direct Direct NNP cord-300061-l2pfl776 9 3 2010 2010 CD cord-300061-l2pfl776 9 4 , , , cord-300061-l2pfl776 9 5 5 5 CD cord-300061-l2pfl776 9 6 : : SYM cord-300061-l2pfl776 9 7 10 10 CD cord-300061-l2pfl776 9 8 ) ) -RRB- cord-300061-l2pfl776 9 9 . . . cord-300061-l2pfl776 10 1 S S NNP cord-300061-l2pfl776 10 2 is be VBZ cord-300061-l2pfl776 10 3 a a DT cord-300061-l2pfl776 10 4 quantity quantity NN cord-300061-l2pfl776 10 5 defined define VBN cord-300061-l2pfl776 10 6 as as IN cord-300061-l2pfl776 10 7 S s NN cord-300061-l2pfl776 10 8 = = SYM cord-300061-l2pfl776 10 9 a(2 a(2 NN cord-300061-l2pfl776 10 10 ) ) -RRB- cord-300061-l2pfl776 11 1 + + CC cord-300061-l2pfl776 11 2 c(2 c(2 NN cord-300061-l2pfl776 11 3 ) ) -RRB- cord-300061-l2pfl776 12 1 + + CC cord-300061-l2pfl776 13 1 g(2 g(2 LS cord-300061-l2pfl776 13 2 ) ) -RRB- cord-300061-l2pfl776 14 1 + + CC cord-300061-l2pfl776 14 2 t(2 t(2 CD cord-300061-l2pfl776 14 3 ) ) -RRB- cord-300061-l2pfl776 14 4 , , , cord-300061-l2pfl776 14 5 where where WRB cord-300061-l2pfl776 14 6 a a DT cord-300061-l2pfl776 14 7 , , , cord-300061-l2pfl776 14 8 c c NNP cord-300061-l2pfl776 14 9 , , , cord-300061-l2pfl776 14 10 g g NNP cord-300061-l2pfl776 14 11 and and CC cord-300061-l2pfl776 14 12 t t NNP cord-300061-l2pfl776 14 13 denote denote VB cord-300061-l2pfl776 14 14 corresponding corresponding JJ cord-300061-l2pfl776 14 15 base base NN cord-300061-l2pfl776 14 16 frequencies frequency NNS cord-300061-l2pfl776 14 17 . . . cord-300061-l2pfl776 15 1 The the DT cord-300061-l2pfl776 15 2 Z z NN cord-300061-l2pfl776 15 3 - - HYPH cord-300061-l2pfl776 15 4 curve curve NN cord-300061-l2pfl776 15 5 is be VBZ cord-300061-l2pfl776 15 6 a a DT cord-300061-l2pfl776 15 7 three three CD cord-300061-l2pfl776 15 8 dimensional dimensional JJ cord-300061-l2pfl776 15 9 curve curve NN cord-300061-l2pfl776 15 10 that that WDT cord-300061-l2pfl776 15 11 represents represent VBZ cord-300061-l2pfl776 15 12 a a DT cord-300061-l2pfl776 15 13 DNA dna NN cord-300061-l2pfl776 15 14 sequence sequence NN cord-300061-l2pfl776 15 15 in in IN cord-300061-l2pfl776 15 16 the the DT cord-300061-l2pfl776 15 17 manner manner NN cord-300061-l2pfl776 15 18 that that IN cord-300061-l2pfl776 15 19 each each DT cord-300061-l2pfl776 15 20 can can MD cord-300061-l2pfl776 15 21 be be VB cord-300061-l2pfl776 15 22 uniquely uniquely RB cord-300061-l2pfl776 15 23 reconstructed reconstruct VBN cord-300061-l2pfl776 15 24 given give VBN cord-300061-l2pfl776 15 25 the the DT cord-300061-l2pfl776 15 26 other other JJ cord-300061-l2pfl776 15 27 . . . cord-300061-l2pfl776 16 1 Elhaik Elhaik NNP cord-300061-l2pfl776 16 2 et et NNP cord-300061-l2pfl776 16 3 al al NNP cord-300061-l2pfl776 16 4 . . NNP cord-300061-l2pfl776 16 5 made make VBD cord-300061-l2pfl776 16 6 4 4 CD cord-300061-l2pfl776 16 7 major major JJ cord-300061-l2pfl776 16 8 claims claim NNS cord-300061-l2pfl776 16 9 . . . cord-300061-l2pfl776 17 1 1 1 LS cord-300061-l2pfl776 17 2 ) ) -RRB- cord-300061-l2pfl776 18 1 In in IN cord-300061-l2pfl776 18 2 the the DT cord-300061-l2pfl776 18 3 previous previous JJ cord-300061-l2pfl776 18 4 mapping mapping NN cord-300061-l2pfl776 18 5 system system NN cord-300061-l2pfl776 18 6 with with IN cord-300061-l2pfl776 18 7 the the DT cord-300061-l2pfl776 18 8 regular regular JJ cord-300061-l2pfl776 18 9 tetrahedron tetrahedron NN cord-300061-l2pfl776 18 10 , , , cord-300061-l2pfl776 18 11 calculation calculation NN cord-300061-l2pfl776 18 12 of of IN cord-300061-l2pfl776 18 13 the the DT cord-300061-l2pfl776 18 14 radius radius NN cord-300061-l2pfl776 18 15 of of IN cord-300061-l2pfl776 18 16 the the DT cord-300061-l2pfl776 18 17 inscribed inscribe VBN cord-300061-l2pfl776 18 18 sphere sphere NN cord-300061-l2pfl776 18 19 is be VBZ cord-300061-l2pfl776 18 20 " " `` cord-300061-l2pfl776 18 21 a a DT cord-300061-l2pfl776 18 22 mathematical mathematical JJ cord-300061-l2pfl776 18 23 error error NN cord-300061-l2pfl776 18 24 " " '' cord-300061-l2pfl776 18 25 . . . cord-300061-l2pfl776 19 1 2 2 LS cord-300061-l2pfl776 19 2 ) ) -RRB- cord-300061-l2pfl776 19 3 S S NNP cord-300061-l2pfl776 19 4 follows follow VBZ cord-300061-l2pfl776 19 5 an an DT cord-300061-l2pfl776 19 6 exponential exponential JJ cord-300061-l2pfl776 19 7 distribution distribution NN cord-300061-l2pfl776 19 8 and and CC cord-300061-l2pfl776 19 9 is be VBZ cord-300061-l2pfl776 19 10 narrowly narrowly RB cord-300061-l2pfl776 19 11 distributed distribute VBN cord-300061-l2pfl776 19 12 with with IN cord-300061-l2pfl776 19 13 a a DT cord-300061-l2pfl776 19 14 range range NN cord-300061-l2pfl776 19 15 of of IN cord-300061-l2pfl776 19 16 ( ( -LRB- cord-300061-l2pfl776 19 17 0.25 0.25 CD cord-300061-l2pfl776 19 18 - - SYM cord-300061-l2pfl776 19 19 0.33 0.33 CD cord-300061-l2pfl776 19 20 ) ) -RRB- cord-300061-l2pfl776 19 21 . . . cord-300061-l2pfl776 20 1 3 3 LS cord-300061-l2pfl776 20 2 ) ) -RRB- cord-300061-l2pfl776 21 1 Based base VBN cord-300061-l2pfl776 21 2 on on IN cord-300061-l2pfl776 21 3 the the DT cord-300061-l2pfl776 21 4 Chargaff Chargaff NNP cord-300061-l2pfl776 21 5 's 's POS cord-300061-l2pfl776 21 6 second second JJ cord-300061-l2pfl776 21 7 parity parity NN cord-300061-l2pfl776 21 8 rule rule NN cord-300061-l2pfl776 21 9 ( ( -LRB- cord-300061-l2pfl776 21 10 PR2 PR2 NNP cord-300061-l2pfl776 21 11 ) ) -RRB- cord-300061-l2pfl776 21 12 , , , cord-300061-l2pfl776 21 13 " " `` cord-300061-l2pfl776 21 14 S S NNP cord-300061-l2pfl776 21 15 is be VBZ cord-300061-l2pfl776 21 16 equivalent equivalent JJ cord-300061-l2pfl776 21 17 to to IN cord-300061-l2pfl776 21 18 H H NNP cord-300061-l2pfl776 21 19 [ [ -LRB- cord-300061-l2pfl776 21 20 Shannon Shannon NNP cord-300061-l2pfl776 21 21 entropy entropy NN cord-300061-l2pfl776 21 22 ] ] -RRB- cord-300061-l2pfl776 21 23 " " `` cord-300061-l2pfl776 21 24 and and CC cord-300061-l2pfl776 21 25 they -PRON- PRP cord-300061-l2pfl776 21 26 are be VBP cord-300061-l2pfl776 21 27 derivable derivable JJ cord-300061-l2pfl776 21 28 from from IN cord-300061-l2pfl776 21 29 each each DT cord-300061-l2pfl776 21 30 other other JJ cord-300061-l2pfl776 21 31 . . . cord-300061-l2pfl776 22 1 4 4 LS cord-300061-l2pfl776 22 2 ) ) -RRB- cord-300061-l2pfl776 22 3 Z z NN cord-300061-l2pfl776 22 4 - - HYPH cord-300061-l2pfl776 22 5 curve curve NN cord-300061-l2pfl776 22 6 " " '' cord-300061-l2pfl776 22 7 suffers suffer VBZ cord-300061-l2pfl776 22 8 from from IN cord-300061-l2pfl776 22 9 over over IN cord-300061-l2pfl776 22 10 dimensionality dimensionality NN cord-300061-l2pfl776 22 11 " " '' cord-300061-l2pfl776 22 12 , , , cord-300061-l2pfl776 22 13 because because IN cord-300061-l2pfl776 22 14 based base VBN cord-300061-l2pfl776 22 15 on on IN cord-300061-l2pfl776 22 16 the the DT cord-300061-l2pfl776 22 17 analysis analysis NN cord-300061-l2pfl776 22 18 of of IN cord-300061-l2pfl776 22 19 235 235 CD cord-300061-l2pfl776 22 20 bacterial bacterial JJ cord-300061-l2pfl776 22 21 genomes genome NNS cord-300061-l2pfl776 22 22 , , , cord-300061-l2pfl776 23 1 x x NNP cord-300061-l2pfl776 23 2 and and CC cord-300061-l2pfl776 23 3 y y NNP cord-300061-l2pfl776 23 4 components component NNS cord-300061-l2pfl776 23 5 contributed contribute VBD cord-300061-l2pfl776 23 6 only only RB cord-300061-l2pfl776 23 7 less less JJR cord-300061-l2pfl776 23 8 than than IN cord-300061-l2pfl776 23 9 1 1 CD cord-300061-l2pfl776 23 10 % % NN cord-300061-l2pfl776 23 11 of of IN cord-300061-l2pfl776 23 12 the the DT cord-300061-l2pfl776 23 13 variance variance NN cord-300061-l2pfl776 23 14 and and CC cord-300061-l2pfl776 23 15 therefore therefore RB cord-300061-l2pfl776 23 16 " " `` cord-300061-l2pfl776 23 17 would would MD cord-300061-l2pfl776 23 18 be be VB cord-300061-l2pfl776 23 19 of of IN cord-300061-l2pfl776 23 20 little little JJ cord-300061-l2pfl776 23 21 use use NN cord-300061-l2pfl776 23 22 " " '' cord-300061-l2pfl776 23 23 . . . cord-300061-l2pfl776 24 1 RESULTS result NNS cord-300061-l2pfl776 24 2 : : : cord-300061-l2pfl776 25 1 1 1 LS cord-300061-l2pfl776 25 2 ) ) -RRB- cord-300061-l2pfl776 26 1 Elhaik Elhaik NNP cord-300061-l2pfl776 26 2 et et NNP cord-300061-l2pfl776 26 3 al al NNP cord-300061-l2pfl776 26 4 . . . cord-300061-l2pfl776 27 1 mistakenly mistakenly RB cord-300061-l2pfl776 27 2 neglected neglect VBD cord-300061-l2pfl776 27 3 the the DT cord-300061-l2pfl776 27 4 parameter parameter NN cord-300061-l2pfl776 27 5 [ [ -LRB- cord-300061-l2pfl776 27 6 Formula formula NN cord-300061-l2pfl776 27 7 : : : cord-300061-l2pfl776 27 8 see see VB cord-300061-l2pfl776 27 9 text text NN cord-300061-l2pfl776 27 10 ] ] -RRB- cord-300061-l2pfl776 27 11 when when WRB cord-300061-l2pfl776 27 12 calculating calculate VBG cord-300061-l2pfl776 27 13 the the DT cord-300061-l2pfl776 27 14 radius radius NN cord-300061-l2pfl776 27 15 of of IN cord-300061-l2pfl776 27 16 the the DT cord-300061-l2pfl776 27 17 inscribed inscribe VBN cord-300061-l2pfl776 27 18 sphere sphere NN cord-300061-l2pfl776 27 19 . . . cord-300061-l2pfl776 28 1 2 2 LS cord-300061-l2pfl776 28 2 ) ) -RRB- cord-300061-l2pfl776 29 1 The the DT cord-300061-l2pfl776 29 2 exponential exponential JJ cord-300061-l2pfl776 29 3 distribution distribution NN cord-300061-l2pfl776 29 4 of of IN cord-300061-l2pfl776 29 5 S S NNP cord-300061-l2pfl776 29 6 is be VBZ cord-300061-l2pfl776 29 7 a a DT cord-300061-l2pfl776 29 8 restatement restatement NN cord-300061-l2pfl776 29 9 of of IN cord-300061-l2pfl776 29 10 our -PRON- PRP$ cord-300061-l2pfl776 29 11 previous previous JJ cord-300061-l2pfl776 29 12 conclusion conclusion NN cord-300061-l2pfl776 29 13 , , , cord-300061-l2pfl776 29 14 and and CC cord-300061-l2pfl776 29 15 the the DT cord-300061-l2pfl776 29 16 range range NN cord-300061-l2pfl776 29 17 of of IN cord-300061-l2pfl776 29 18 ( ( -LRB- cord-300061-l2pfl776 29 19 0.25 0.25 CD cord-300061-l2pfl776 29 20 - - SYM cord-300061-l2pfl776 29 21 0.33 0.33 CD cord-300061-l2pfl776 29 22 ) ) -RRB- cord-300061-l2pfl776 29 23 only only RB cord-300061-l2pfl776 29 24 paraphrases paraphrase VBZ cord-300061-l2pfl776 29 25 the the DT cord-300061-l2pfl776 29 26 previously previously RB cord-300061-l2pfl776 29 27 suggested suggest VBN cord-300061-l2pfl776 29 28 S S NNP cord-300061-l2pfl776 29 29 range range NN cord-300061-l2pfl776 29 30 ( ( -LRB- cord-300061-l2pfl776 29 31 0.25 0.25 CD cord-300061-l2pfl776 29 32 -1/3 -1/3 NN cord-300061-l2pfl776 29 33 ) ) -RRB- cord-300061-l2pfl776 29 34 . . . cord-300061-l2pfl776 30 1 3 3 LS cord-300061-l2pfl776 30 2 ) ) -RRB- cord-300061-l2pfl776 31 1 Elhaik Elhaik NNP cord-300061-l2pfl776 31 2 et et NNP cord-300061-l2pfl776 31 3 al al NNP cord-300061-l2pfl776 31 4 . . . cord-300061-l2pfl776 32 1 incorrectly incorrectly RB cord-300061-l2pfl776 32 2 disregard disregard JJ cord-300061-l2pfl776 32 3 deviations deviation NNS cord-300061-l2pfl776 32 4 from from IN cord-300061-l2pfl776 32 5 PR2 PR2 NNP cord-300061-l2pfl776 32 6 by by IN cord-300061-l2pfl776 32 7 treating treat VBG cord-300061-l2pfl776 32 8 the the DT cord-300061-l2pfl776 32 9 deviations deviation NNS cord-300061-l2pfl776 32 10 as as IN cord-300061-l2pfl776 32 11 0 0 CD cord-300061-l2pfl776 32 12 altogether altogether RB cord-300061-l2pfl776 32 13 , , , cord-300061-l2pfl776 32 14 reduce reduce VB cord-300061-l2pfl776 32 15 S S NNP cord-300061-l2pfl776 32 16 and and CC cord-300061-l2pfl776 32 17 H H NNP cord-300061-l2pfl776 32 18 , , , cord-300061-l2pfl776 32 19 both both DT cord-300061-l2pfl776 32 20 having have VBG cord-300061-l2pfl776 32 21 4 4 CD cord-300061-l2pfl776 32 22 variables variable NNS cord-300061-l2pfl776 32 23 , , , cord-300061-l2pfl776 32 24 a a NN cord-300061-l2pfl776 32 25 , , , cord-300061-l2pfl776 32 26 c c NNP cord-300061-l2pfl776 32 27 , , , cord-300061-l2pfl776 32 28 g g NNP cord-300061-l2pfl776 32 29 and and CC cord-300061-l2pfl776 32 30 t t NNP cord-300061-l2pfl776 32 31 , , , cord-300061-l2pfl776 32 32 into into IN cord-300061-l2pfl776 32 33 functions function NNS cord-300061-l2pfl776 32 34 of of IN cord-300061-l2pfl776 32 35 one one CD cord-300061-l2pfl776 32 36 single single JJ cord-300061-l2pfl776 32 37 variable variable NN cord-300061-l2pfl776 32 38 , , , cord-300061-l2pfl776 32 39 a a DT cord-300061-l2pfl776 32 40 only only RB cord-300061-l2pfl776 32 41 , , , cord-300061-l2pfl776 32 42 and and CC cord-300061-l2pfl776 32 43 apply apply VB cord-300061-l2pfl776 32 44 this this DT cord-300061-l2pfl776 32 45 treatment treatment NN cord-300061-l2pfl776 32 46 to to IN cord-300061-l2pfl776 32 47 all all DT cord-300061-l2pfl776 32 48 DNA dna NN cord-300061-l2pfl776 32 49 sequences sequence NNS cord-300061-l2pfl776 32 50 as as IN cord-300061-l2pfl776 32 51 the the DT cord-300061-l2pfl776 32 52 basis basis NN cord-300061-l2pfl776 32 53 of of IN cord-300061-l2pfl776 32 54 their -PRON- PRP$ cord-300061-l2pfl776 32 55 " " `` cord-300061-l2pfl776 32 56 demonstration demonstration NN cord-300061-l2pfl776 32 57 " " '' cord-300061-l2pfl776 32 58 , , , cord-300061-l2pfl776 32 59 which which WDT cord-300061-l2pfl776 32 60 is be VBZ cord-300061-l2pfl776 32 61 therefore therefore RB cord-300061-l2pfl776 32 62 invalid invalid JJ cord-300061-l2pfl776 32 63 . . . cord-300061-l2pfl776 33 1 4 4 LS cord-300061-l2pfl776 33 2 ) ) -RRB- cord-300061-l2pfl776 34 1 Elhaik Elhaik NNP cord-300061-l2pfl776 34 2 et et NNP cord-300061-l2pfl776 34 3 al al NNP cord-300061-l2pfl776 34 4 . . . cord-300061-l2pfl776 35 1 confuse confuse VB cord-300061-l2pfl776 35 2 numeral numeral JJ cord-300061-l2pfl776 35 3 smallness smallness NN cord-300061-l2pfl776 35 4 with with IN cord-300061-l2pfl776 35 5 biological biological JJ cord-300061-l2pfl776 35 6 insignificance insignificance NN cord-300061-l2pfl776 35 7 , , , cord-300061-l2pfl776 35 8 and and CC cord-300061-l2pfl776 35 9 disregard disregard VB cord-300061-l2pfl776 35 10 the the DT cord-300061-l2pfl776 35 11 distributions distribution NNS cord-300061-l2pfl776 35 12 of of IN cord-300061-l2pfl776 35 13 purine purine NN cord-300061-l2pfl776 35 14 / / SYM cord-300061-l2pfl776 35 15 pyrimidine pyrimidine NN cord-300061-l2pfl776 35 16 and and CC cord-300061-l2pfl776 35 17 amino amino NNS cord-300061-l2pfl776 35 18 / / SYM cord-300061-l2pfl776 35 19 keto keto NNP cord-300061-l2pfl776 35 20 bases basis NNS cord-300061-l2pfl776 35 21 ( ( -LRB- cord-300061-l2pfl776 35 22 x x SYM cord-300061-l2pfl776 35 23 and and CC cord-300061-l2pfl776 35 24 y y NNP cord-300061-l2pfl776 35 25 components components NNP cord-300061-l2pfl776 35 26 ) ) -RRB- cord-300061-l2pfl776 35 27 , , , cord-300061-l2pfl776 35 28 the the DT cord-300061-l2pfl776 35 29 variations variation NNS cord-300061-l2pfl776 35 30 of of IN cord-300061-l2pfl776 35 31 which which WDT cord-300061-l2pfl776 35 32 , , , cord-300061-l2pfl776 35 33 although although IN cord-300061-l2pfl776 35 34 can can MD cord-300061-l2pfl776 35 35 be be VB cord-300061-l2pfl776 35 36 less less JJR cord-300061-l2pfl776 35 37 than than IN cord-300061-l2pfl776 35 38 that that DT cord-300061-l2pfl776 35 39 of of IN cord-300061-l2pfl776 35 40 GC GC NNP cord-300061-l2pfl776 35 41 content content NN cord-300061-l2pfl776 35 42 , , , cord-300061-l2pfl776 35 43 contain contain VBP cord-300061-l2pfl776 35 44 rich rich JJ cord-300061-l2pfl776 35 45 information information NN cord-300061-l2pfl776 35 46 that that WDT cord-300061-l2pfl776 35 47 is be VBZ cord-300061-l2pfl776 35 48 important important JJ cord-300061-l2pfl776 35 49 and and CC cord-300061-l2pfl776 35 50 useful useful JJ cord-300061-l2pfl776 35 51 , , , cord-300061-l2pfl776 35 52 such such JJ cord-300061-l2pfl776 35 53 as as IN cord-300061-l2pfl776 35 54 in in IN cord-300061-l2pfl776 35 55 locating locate VBG cord-300061-l2pfl776 35 56 replication replication NN cord-300061-l2pfl776 35 57 origins origin NNS cord-300061-l2pfl776 35 58 of of IN cord-300061-l2pfl776 35 59 bacterial bacterial JJ cord-300061-l2pfl776 35 60 and and CC cord-300061-l2pfl776 35 61 archaeal archaeal JJ cord-300061-l2pfl776 35 62 genomes genome NNS cord-300061-l2pfl776 35 63 , , , cord-300061-l2pfl776 35 64 and and CC cord-300061-l2pfl776 35 65 in in IN cord-300061-l2pfl776 35 66 studies study NNS cord-300061-l2pfl776 35 67 of of IN cord-300061-l2pfl776 35 68 gene gene NN cord-300061-l2pfl776 35 69 recognition recognition NN cord-300061-l2pfl776 35 70 in in IN cord-300061-l2pfl776 35 71 various various JJ cord-300061-l2pfl776 35 72 species specie NNS cord-300061-l2pfl776 35 73 . . . cord-300061-l2pfl776 36 1 CONCLUSION conclusion NN cord-300061-l2pfl776 36 2 : : : cord-300061-l2pfl776 37 1 Elhaik Elhaik NNP cord-300061-l2pfl776 37 2 et et NNP cord-300061-l2pfl776 37 3 al al NNP cord-300061-l2pfl776 37 4 . . . cord-300061-l2pfl776 38 1 confuse confuse VB cord-300061-l2pfl776 38 2 S S NNP cord-300061-l2pfl776 38 3 ( ( -LRB- cord-300061-l2pfl776 38 4 a a DT cord-300061-l2pfl776 38 5 single single JJ cord-300061-l2pfl776 38 6 number number NN cord-300061-l2pfl776 38 7 ) ) -RRB- cord-300061-l2pfl776 38 8 with with IN cord-300061-l2pfl776 38 9 Z z NN cord-300061-l2pfl776 38 10 - - HYPH cord-300061-l2pfl776 38 11 curve curve NN cord-300061-l2pfl776 38 12 ( ( -LRB- cord-300061-l2pfl776 38 13 a a DT cord-300061-l2pfl776 38 14 series series NN cord-300061-l2pfl776 38 15 of of IN cord-300061-l2pfl776 38 16 3D 3D NNP cord-300061-l2pfl776 38 17 coordinates coordinates NNP cord-300061-l2pfl776 38 18 ) ) -RRB- cord-300061-l2pfl776 38 19 , , , cord-300061-l2pfl776 38 20 which which WDT cord-300061-l2pfl776 38 21 are be VBP cord-300061-l2pfl776 38 22 distinct distinct JJ cord-300061-l2pfl776 38 23 . . . cord-300061-l2pfl776 39 1 To to TO cord-300061-l2pfl776 39 2 use use VB cord-300061-l2pfl776 39 3 S S NNP cord-300061-l2pfl776 39 4 as as IN cord-300061-l2pfl776 39 5 a a DT cord-300061-l2pfl776 39 6 case case NN cord-300061-l2pfl776 39 7 study study NN cord-300061-l2pfl776 39 8 of of IN cord-300061-l2pfl776 39 9 Z z NN cord-300061-l2pfl776 39 10 - - HYPH cord-300061-l2pfl776 39 11 curve curve NN cord-300061-l2pfl776 39 12 , , , cord-300061-l2pfl776 39 13 by by IN cord-300061-l2pfl776 39 14 itself -PRON- PRP cord-300061-l2pfl776 39 15 , , , cord-300061-l2pfl776 39 16 is be VBZ cord-300061-l2pfl776 39 17 invalid invalid JJ cord-300061-l2pfl776 39 18 . . . cord-300061-l2pfl776 40 1 S S NNP cord-300061-l2pfl776 40 2 and and CC cord-300061-l2pfl776 40 3 H H NNP cord-300061-l2pfl776 40 4 are be VBP cord-300061-l2pfl776 40 5 neither neither RB cord-300061-l2pfl776 40 6 equivalent equivalent JJ cord-300061-l2pfl776 40 7 nor nor CC cord-300061-l2pfl776 40 8 derivable derivable JJ cord-300061-l2pfl776 40 9 from from IN cord-300061-l2pfl776 40 10 each each DT cord-300061-l2pfl776 40 11 other other JJ cord-300061-l2pfl776 40 12 . . . cord-300061-l2pfl776 41 1 The the DT cord-300061-l2pfl776 41 2 criticisms criticism NNS cord-300061-l2pfl776 41 3 of of IN cord-300061-l2pfl776 41 4 Elhaik Elhaik NNP cord-300061-l2pfl776 41 5 , , , cord-300061-l2pfl776 41 6 Graur Graur NNP cord-300061-l2pfl776 41 7 and and CC cord-300061-l2pfl776 41 8 Josic Josic NNP cord-300061-l2pfl776 41 9 are be VBP cord-300061-l2pfl776 41 10 wrong wrong JJ cord-300061-l2pfl776 41 11 . . . cord-300061-l2pfl776 42 1 REVIEWERS reviewer NNS cord-300061-l2pfl776 42 2 : : : cord-300061-l2pfl776 43 1 This this DT cord-300061-l2pfl776 43 2 article article NN cord-300061-l2pfl776 43 3 was be VBD cord-300061-l2pfl776 43 4 reviewed review VBN cord-300061-l2pfl776 43 5 by by IN cord-300061-l2pfl776 43 6 Erik Erik NNP cord-300061-l2pfl776 43 7 van van NNP cord-300061-l2pfl776 43 8 Nimwegen Nimwegen NNP cord-300061-l2pfl776 43 9 . . . cord-300061-l2pfl776 44 1 The the DT cord-300061-l2pfl776 44 2 debate debate NN cord-300061-l2pfl776 44 3 originated originate VBD cord-300061-l2pfl776 44 4 from from IN cord-300061-l2pfl776 44 5 a a DT cord-300061-l2pfl776 44 6 paper paper NN cord-300061-l2pfl776 44 7 published publish VBN cord-300061-l2pfl776 44 8 in in IN cord-300061-l2pfl776 44 9 1991 1991 CD cord-300061-l2pfl776 44 10 , , , cord-300061-l2pfl776 44 11 in in IN cord-300061-l2pfl776 44 12 which which WDT cord-300061-l2pfl776 44 13 we -PRON- PRP cord-300061-l2pfl776 44 14 defined define VBD cord-300061-l2pfl776 44 15 a a DT cord-300061-l2pfl776 44 16 quantity quantity NN cord-300061-l2pfl776 44 17 S s NN cord-300061-l2pfl776 44 18 = = NN cord-300061-l2pfl776 45 1 a a DT cord-300061-l2pfl776 45 2 2 2 CD cord-300061-l2pfl776 45 3 + + SYM cord-300061-l2pfl776 45 4 c c NN cord-300061-l2pfl776 45 5 2 2 CD cord-300061-l2pfl776 45 6 + + CC cord-300061-l2pfl776 45 7 g g NN cord-300061-l2pfl776 45 8 2 2 CD cord-300061-l2pfl776 46 1 + + CC cord-300061-l2pfl776 47 1 t t NNP cord-300061-l2pfl776 47 2 2 2 CD cord-300061-l2pfl776 47 3 , , , cord-300061-l2pfl776 47 4 where where WRB cord-300061-l2pfl776 47 5 a a DT cord-300061-l2pfl776 47 6 , , , cord-300061-l2pfl776 47 7 c c NNP cord-300061-l2pfl776 47 8 , , , cord-300061-l2pfl776 47 9 g g NNP cord-300061-l2pfl776 47 10 and and CC cord-300061-l2pfl776 47 11 t t NNP cord-300061-l2pfl776 47 12 denote denote VB cord-300061-l2pfl776 47 13 corresponding corresponding JJ cord-300061-l2pfl776 47 14 base base NN cord-300061-l2pfl776 47 15 frequencies frequency NNS cord-300061-l2pfl776 47 16 in in IN cord-300061-l2pfl776 47 17 a a DT cord-300061-l2pfl776 47 18 DNA dna NN cord-300061-l2pfl776 47 19 sequence sequence NN cord-300061-l2pfl776 47 20 , , , cord-300061-l2pfl776 47 21 and and CC cord-300061-l2pfl776 47 22 we -PRON- PRP cord-300061-l2pfl776 47 23 studied study VBD cord-300061-l2pfl776 47 24 S S NNP cord-300061-l2pfl776 47 25 values value NNS cord-300061-l2pfl776 47 26 for for IN cord-300061-l2pfl776 47 27 protein protein NN cord-300061-l2pfl776 47 28 coding coding NN cord-300061-l2pfl776 47 29 genes gene NNS cord-300061-l2pfl776 47 30 [ [ -LRB- cord-300061-l2pfl776 47 31 1 1 CD cord-300061-l2pfl776 47 32 ] ] -RRB- cord-300061-l2pfl776 47 33 . . . cord-300061-l2pfl776 48 1 In in IN cord-300061-l2pfl776 48 2 2004 2004 CD cord-300061-l2pfl776 48 3 , , , cord-300061-l2pfl776 48 4 we -PRON- PRP cord-300061-l2pfl776 48 5 calculated calculate VBD cord-300061-l2pfl776 48 6 S S NNP cord-300061-l2pfl776 48 7 values value NNS cord-300061-l2pfl776 48 8 for for IN cord-300061-l2pfl776 48 9 genome genome NN cord-300061-l2pfl776 48 10 sequences sequence NNS cord-300061-l2pfl776 48 11 , , , cord-300061-l2pfl776 48 12 and and CC cord-300061-l2pfl776 48 13 found find VBD cord-300061-l2pfl776 48 14 that that IN cord-300061-l2pfl776 48 15 S s NN cord-300061-l2pfl776 48 16 < < XX cord-300061-l2pfl776 48 17 1/3 1/3 CD cord-300061-l2pfl776 48 18 is be VBZ cord-300061-l2pfl776 48 19 valid valid JJ cord-300061-l2pfl776 48 20 for for IN cord-300061-l2pfl776 48 21 most most JJS cord-300061-l2pfl776 48 22 genomes genome NNS cord-300061-l2pfl776 48 23 [ [ -LRB- cord-300061-l2pfl776 48 24 2 2 CD cord-300061-l2pfl776 48 25 ] ] -RRB- cord-300061-l2pfl776 48 26 . . . cord-300061-l2pfl776 49 1 In in IN cord-300061-l2pfl776 49 2 2008 2008 CD cord-300061-l2pfl776 49 3 , , , cord-300061-l2pfl776 49 4 Elhaik Elhaik NNP cord-300061-l2pfl776 49 5 et et NNP cord-300061-l2pfl776 49 6 al al NNP cord-300061-l2pfl776 49 7 . . . cord-300061-l2pfl776 49 8 criticized criticize VBD cord-300061-l2pfl776 49 9 this this DT cord-300061-l2pfl776 49 10 work work NN cord-300061-l2pfl776 49 11 with with IN cord-300061-l2pfl776 49 12 2 2 CD cord-300061-l2pfl776 49 13 claims claim NNS cord-300061-l2pfl776 49 14 [ [ -LRB- cord-300061-l2pfl776 49 15 3 3 CD cord-300061-l2pfl776 49 16 ] ] -RRB- cord-300061-l2pfl776 49 17 . . . cord-300061-l2pfl776 50 1 1 1 LS cord-300061-l2pfl776 50 2 . . . cord-300061-l2pfl776 51 1 S S NNP cord-300061-l2pfl776 51 2 < < XX cord-300061-l2pfl776 51 3 S S NNP cord-300061-l2pfl776 51 4 1/3 1/3 CD cord-300061-l2pfl776 51 5 is be VBZ cord-300061-l2pfl776 51 6 in in IN cord-300061-l2pfl776 51 7 fact fact NN cord-300061-l2pfl776 51 8 a a DT cord-300061-l2pfl776 51 9 mathematical mathematical JJ cord-300061-l2pfl776 51 10 property property NN cord-300061-l2pfl776 51 11 that that WDT cord-300061-l2pfl776 51 12 is be VBZ cord-300061-l2pfl776 51 13 always always RB cord-300061-l2pfl776 51 14 true true JJ cord-300061-l2pfl776 51 15 regardless regardless RB cord-300061-l2pfl776 51 16 of of IN cord-300061-l2pfl776 51 17 specific specific JJ cord-300061-l2pfl776 51 18 data datum NNS cord-300061-l2pfl776 51 19 . . . cord-300061-l2pfl776 52 1 2 2 LS cord-300061-l2pfl776 52 2 . . . cord-300061-l2pfl776 53 1 S S NNP cord-300061-l2pfl776 53 2 and and CC cord-300061-l2pfl776 53 3 H H NNP cord-300061-l2pfl776 53 4 ( ( -LRB- cord-300061-l2pfl776 53 5 Shannon Shannon NNP cord-300061-l2pfl776 53 6 entropy entropy NN cord-300061-l2pfl776 53 7 ) ) -RRB- cord-300061-l2pfl776 53 8 are be VBP cord-300061-l2pfl776 53 9 strictly strictly RB cord-300061-l2pfl776 53 10 equivalent equivalent JJ cord-300061-l2pfl776 53 11 . . . cord-300061-l2pfl776 54 1 To to TO cord-300061-l2pfl776 54 2 rebut rebut VB cord-300061-l2pfl776 54 3 with with IN cord-300061-l2pfl776 54 4 minimum minimum JJ cord-300061-l2pfl776 54 5 space space NN cord-300061-l2pfl776 54 6 , , , cord-300061-l2pfl776 54 7 I -PRON- PRP cord-300061-l2pfl776 54 8 raised raise VBD cord-300061-l2pfl776 54 9 one one CD cord-300061-l2pfl776 54 10 counterexample counterexample NN cord-300061-l2pfl776 54 11 to to IN cord-300061-l2pfl776 54 12 each each DT cord-300061-l2pfl776 54 13 claim claim NN cord-300061-l2pfl776 54 14 [ [ -LRB- cord-300061-l2pfl776 54 15 4 4 CD cord-300061-l2pfl776 54 16 ] ] -RRB- cord-300061-l2pfl776 54 17 . . . cord-300061-l2pfl776 55 1 1 1 LS cord-300061-l2pfl776 55 2 . . . cord-300061-l2pfl776 56 1 When when WRB cord-300061-l2pfl776 56 2 a a DT cord-300061-l2pfl776 56 3 = = SYM cord-300061-l2pfl776 56 4 c c NN cord-300061-l2pfl776 56 5 = = SYM cord-300061-l2pfl776 56 6 0.5 0.5 CD cord-300061-l2pfl776 56 7 , , , cord-300061-l2pfl776 56 8 g g NN cord-300061-l2pfl776 56 9 = = SYM cord-300061-l2pfl776 56 10 t t NN cord-300061-l2pfl776 56 11 = = SYM cord-300061-l2pfl776 56 12 0 0 CD cord-300061-l2pfl776 56 13 , , , cord-300061-l2pfl776 56 14 S s NN cord-300061-l2pfl776 56 15 = = SYM cord-300061-l2pfl776 56 16 0.5 0.5 CD cord-300061-l2pfl776 56 17 , , , cord-300061-l2pfl776 56 18 which which WDT cord-300061-l2pfl776 56 19 is be VBZ cord-300061-l2pfl776 56 20 larger large JJR cord-300061-l2pfl776 56 21 than than IN cord-300061-l2pfl776 56 22 1/3 1/3 CD cord-300061-l2pfl776 57 1 ; ; : cord-300061-l2pfl776 57 2 thus thus RB cord-300061-l2pfl776 57 3 S S NNP cord-300061-l2pfl776 57 4 < < XX cord-300061-l2pfl776 57 5 1/3 1/3 CD cord-300061-l2pfl776 57 6 is be VBZ cord-300061-l2pfl776 57 7 not not RB cord-300061-l2pfl776 57 8 a a DT cord-300061-l2pfl776 57 9 mathematical mathematical JJ cord-300061-l2pfl776 57 10 property property NN cord-300061-l2pfl776 57 11 that that WDT cord-300061-l2pfl776 57 12 is be VBZ cord-300061-l2pfl776 57 13 always always RB cord-300061-l2pfl776 57 14 true true JJ cord-300061-l2pfl776 57 15 , , , cord-300061-l2pfl776 57 16 and and CC cord-300061-l2pfl776 57 17 it -PRON- PRP cord-300061-l2pfl776 57 18 depends depend VBZ cord-300061-l2pfl776 57 19 on on IN cord-300061-l2pfl776 57 20 specific specific JJ cord-300061-l2pfl776 57 21 data datum NNS cord-300061-l2pfl776 57 22 to to TO cord-300061-l2pfl776 57 23 be be VB cord-300061-l2pfl776 57 24 valid valid JJ cord-300061-l2pfl776 57 25 . . . cord-300061-l2pfl776 58 1 2 2 LS cord-300061-l2pfl776 58 2 . . . cord-300061-l2pfl776 59 1 H h NN cord-300061-l2pfl776 59 2 , , , cord-300061-l2pfl776 59 3 but but CC cord-300061-l2pfl776 59 4 not not RB cord-300061-l2pfl776 59 5 S S NNP cord-300061-l2pfl776 59 6 , , , cord-300061-l2pfl776 59 7 has have VBZ cord-300061-l2pfl776 59 8 the the DT cord-300061-l2pfl776 59 9 property property NN cord-300061-l2pfl776 59 10 of of IN cord-300061-l2pfl776 59 11 additivity additivity NN cord-300061-l2pfl776 59 12 of of IN cord-300061-l2pfl776 59 13 information information NN cord-300061-l2pfl776 59 14 entropy entropy NN cord-300061-l2pfl776 59 15 ; ; : cord-300061-l2pfl776 59 16 they -PRON- PRP cord-300061-l2pfl776 59 17 thus thus RB cord-300061-l2pfl776 59 18 differ differ VBP cord-300061-l2pfl776 59 19 . . . cord-300061-l2pfl776 60 1 Therefore therefore RB cord-300061-l2pfl776 60 2 , , , cord-300061-l2pfl776 60 3 both both DT cord-300061-l2pfl776 60 4 claims claim NNS cord-300061-l2pfl776 60 5 are be VBP cord-300061-l2pfl776 60 6 incorrect incorrect JJ cord-300061-l2pfl776 60 7 [ [ -LRB- cord-300061-l2pfl776 60 8 4 4 CD cord-300061-l2pfl776 60 9 ] ] -RRB- cord-300061-l2pfl776 60 10 . . . cord-300061-l2pfl776 61 1 In in IN cord-300061-l2pfl776 61 2 a a DT cord-300061-l2pfl776 61 3 more more RBR cord-300061-l2pfl776 61 4 recent recent JJ cord-300061-l2pfl776 61 5 comment comment NN cord-300061-l2pfl776 61 6 published publish VBN cord-300061-l2pfl776 61 7 in in IN cord-300061-l2pfl776 61 8 Biology Biology NNP cord-300061-l2pfl776 61 9 Direct Direct NNP cord-300061-l2pfl776 61 10 [ [ -LRB- cord-300061-l2pfl776 61 11 5 5 CD cord-300061-l2pfl776 61 12 ] ] -RRB- cord-300061-l2pfl776 61 13 , , , cord-300061-l2pfl776 61 14 Elhaik Elhaik NNP cord-300061-l2pfl776 61 15 et et NNP cord-300061-l2pfl776 61 16 al al NNP cord-300061-l2pfl776 61 17 . . NNP cord-300061-l2pfl776 61 18 dropped drop VBD cord-300061-l2pfl776 61 19 the the DT cord-300061-l2pfl776 61 20 first first JJ cord-300061-l2pfl776 61 21 claim claim NN cord-300061-l2pfl776 61 22 , , , cord-300061-l2pfl776 61 23 but but CC cord-300061-l2pfl776 61 24 still still RB cord-300061-l2pfl776 61 25 insisted insist VBD cord-300061-l2pfl776 61 26 on on IN cord-300061-l2pfl776 61 27 the the DT cord-300061-l2pfl776 61 28 equivalence equivalence NN cord-300061-l2pfl776 61 29 of of IN cord-300061-l2pfl776 61 30 S S NNP cord-300061-l2pfl776 61 31 and and CC cord-300061-l2pfl776 61 32 H. h. NN cord-300061-l2pfl776 62 1 Furthermore furthermore RB cord-300061-l2pfl776 62 2 , , , cord-300061-l2pfl776 62 3 they -PRON- PRP cord-300061-l2pfl776 62 4 made make VBD cord-300061-l2pfl776 62 5 additional additional JJ cord-300061-l2pfl776 62 6 criticisms criticism NNS cord-300061-l2pfl776 62 7 , , , cord-300061-l2pfl776 62 8 which which WDT cord-300061-l2pfl776 62 9 , , , cord-300061-l2pfl776 62 10 however however RB cord-300061-l2pfl776 62 11 , , , cord-300061-l2pfl776 62 12 are be VBP cord-300061-l2pfl776 62 13 once once RB cord-300061-l2pfl776 62 14 again again RB cord-300061-l2pfl776 62 15 incorrect incorrect JJ cord-300061-l2pfl776 62 16 , , , cord-300061-l2pfl776 62 17 and and CC cord-300061-l2pfl776 62 18 the the DT cord-300061-l2pfl776 62 19 reasons reason NNS cord-300061-l2pfl776 62 20 are be VBP cord-300061-l2pfl776 62 21 summarized summarize VBN cord-300061-l2pfl776 62 22 in in IN cord-300061-l2pfl776 62 23 this this DT cord-300061-l2pfl776 62 24 rebuttal rebuttal NN cord-300061-l2pfl776 62 25 . . . cord-300061-l2pfl776 63 1 To to TO cord-300061-l2pfl776 63 2 make make VB cord-300061-l2pfl776 63 3 it -PRON- PRP cord-300061-l2pfl776 63 4 easy easy JJ cord-300061-l2pfl776 63 5 to to TO cord-300061-l2pfl776 63 6 follow follow VB cord-300061-l2pfl776 63 7 , , , cord-300061-l2pfl776 63 8 subtitles subtitle NNS cord-300061-l2pfl776 63 9 here here RB cord-300061-l2pfl776 63 10 correspond correspond VBP cord-300061-l2pfl776 63 11 to to IN cord-300061-l2pfl776 63 12 the the DT cord-300061-l2pfl776 63 13 ones one NNS cord-300061-l2pfl776 63 14 in in IN cord-300061-l2pfl776 63 15 [ [ -LRB- cord-300061-l2pfl776 63 16 5 5 CD cord-300061-l2pfl776 63 17 ] ] -RRB- cord-300061-l2pfl776 63 18 . . . cord-300061-l2pfl776 64 1 Inscribed inscribe VBN cord-300061-l2pfl776 64 2 sphere sphere NN cord-300061-l2pfl776 64 3 or or CC cord-300061-l2pfl776 64 4 circumscribed circumscribed JJ cord-300061-l2pfl776 64 5 sphere sphere NN cord-300061-l2pfl776 64 6 ? ? . cord-300061-l2pfl776 65 1 In in IN cord-300061-l2pfl776 65 2 [ [ -LRB- cord-300061-l2pfl776 65 3 1 1 CD cord-300061-l2pfl776 65 4 ] ] -RRB- cord-300061-l2pfl776 65 5 , , , cord-300061-l2pfl776 65 6 we -PRON- PRP cord-300061-l2pfl776 65 7 introduced introduce VBD cord-300061-l2pfl776 65 8 a a DT cord-300061-l2pfl776 65 9 method method NN cord-300061-l2pfl776 65 10 that that WDT cord-300061-l2pfl776 65 11 maps map VBZ cord-300061-l2pfl776 65 12 a a DT cord-300061-l2pfl776 65 13 DNA dna NN cord-300061-l2pfl776 65 14 sequence sequence NN cord-300061-l2pfl776 65 15 onto onto IN cord-300061-l2pfl776 65 16 a a DT cord-300061-l2pfl776 65 17 point point NN cord-300061-l2pfl776 65 18 within within IN cord-300061-l2pfl776 65 19 the the DT cord-300061-l2pfl776 65 20 regular regular JJ cord-300061-l2pfl776 65 21 tetrahedron tetrahedron NN cord-300061-l2pfl776 65 22 ( ( -LRB- cord-300061-l2pfl776 65 23 RT RT NNP cord-300061-l2pfl776 65 24 ) ) -RRB- cord-300061-l2pfl776 65 25 . . . cord-300061-l2pfl776 66 1 In in IN cord-300061-l2pfl776 66 2 [ [ -LRB- cord-300061-l2pfl776 66 3 2 2 CD cord-300061-l2pfl776 66 4 ] ] -RRB- cord-300061-l2pfl776 66 5 , , , cord-300061-l2pfl776 66 6 we -PRON- PRP cord-300061-l2pfl776 66 7 showed show VBD cord-300061-l2pfl776 66 8 that that IN cord-300061-l2pfl776 66 9 for for IN cord-300061-l2pfl776 66 10 most most JJS cord-300061-l2pfl776 66 11 genomes genome NNS cord-300061-l2pfl776 66 12 , , , cord-300061-l2pfl776 66 13 S S NNP cord-300061-l2pfl776 66 14 < < XX cord-300061-l2pfl776 66 15 1/3 1/3 CD cord-300061-l2pfl776 66 16 , , , cord-300061-l2pfl776 66 17 that that RB cord-300061-l2pfl776 66 18 is is RB cord-300061-l2pfl776 66 19 , , , cord-300061-l2pfl776 66 20 the the DT cord-300061-l2pfl776 66 21 mapping mapping NN cord-300061-l2pfl776 66 22 points point NNS cord-300061-l2pfl776 66 23 are be VBP cord-300061-l2pfl776 66 24 within within IN cord-300061-l2pfl776 66 25 the the DT cord-300061-l2pfl776 66 26 inscribed inscribe VBN cord-300061-l2pfl776 66 27 sphere sphere NN cord-300061-l2pfl776 66 28 of of IN cord-300061-l2pfl776 66 29 the the DT cord-300061-l2pfl776 66 30 RT RT NNP cord-300061-l2pfl776 66 31 . . . cord-300061-l2pfl776 67 1 Elhaik Elhaik NNP cord-300061-l2pfl776 67 2 et et NNP cord-300061-l2pfl776 67 3 al al NNP cord-300061-l2pfl776 67 4 . . NNP cord-300061-l2pfl776 67 5 claimed claim VBD cord-300061-l2pfl776 67 6 that that IN cord-300061-l2pfl776 67 7 " " `` cord-300061-l2pfl776 67 8 the the DT cord-300061-l2pfl776 67 9 inscribed inscribe VBN cord-300061-l2pfl776 67 10 sphere sphere NN cord-300061-l2pfl776 67 11 calculations calculation NNS cord-300061-l2pfl776 67 12 were be VBD cord-300061-l2pfl776 67 13 erroneous erroneous JJ cord-300061-l2pfl776 67 14 " " '' cord-300061-l2pfl776 67 15 , , , cord-300061-l2pfl776 67 16 and and CC cord-300061-l2pfl776 67 17 the the DT cord-300061-l2pfl776 67 18 conclusion conclusion NN cord-300061-l2pfl776 67 19 that that WDT cord-300061-l2pfl776 67 20 S s NN cord-300061-l2pfl776 67 21 < < XX cord-300061-l2pfl776 67 22 1/3 1/3 CD cord-300061-l2pfl776 67 23 and and CC cord-300061-l2pfl776 67 24 the the DT cord-300061-l2pfl776 67 25 mapping mapping NN cord-300061-l2pfl776 67 26 points point NNS cord-300061-l2pfl776 67 27 are be VBP cord-300061-l2pfl776 67 28 within within IN cord-300061-l2pfl776 67 29 the the DT cord-300061-l2pfl776 67 30 inscribed inscribe VBN cord-300061-l2pfl776 67 31 sphere sphere NN cord-300061-l2pfl776 67 32 is be VBZ cord-300061-l2pfl776 67 33 " " `` cord-300061-l2pfl776 67 34 a a DT cord-300061-l2pfl776 67 35 consequence consequence NN cord-300061-l2pfl776 67 36 of of IN cord-300061-l2pfl776 67 37 a a DT cord-300061-l2pfl776 67 38 mathematical mathematical JJ cord-300061-l2pfl776 67 39 error error NN cord-300061-l2pfl776 67 40 " " '' cord-300061-l2pfl776 67 41 , , , cord-300061-l2pfl776 67 42 because because IN cord-300061-l2pfl776 67 43 they -PRON- PRP cord-300061-l2pfl776 67 44 noted note VBD cord-300061-l2pfl776 67 45 that that IN cord-300061-l2pfl776 67 46 the the DT cord-300061-l2pfl776 67 47 radius radius NN cord-300061-l2pfl776 67 48 of of IN cord-300061-l2pfl776 67 49 the the DT cord-300061-l2pfl776 67 50 inscribed inscribe VBN cord-300061-l2pfl776 67 51 sphere sphere NN cord-300061-l2pfl776 67 52 of of IN cord-300061-l2pfl776 67 53 the the DT cord-300061-l2pfl776 67 54 RT RT NNP cord-300061-l2pfl776 67 55 involved involve VBN cord-300061-l2pfl776 67 56 is be VBZ cord-300061-l2pfl776 67 57 1/4 1/4 CD cord-300061-l2pfl776 67 58 rather rather RB cord-300061-l2pfl776 67 59 than than IN cord-300061-l2pfl776 67 60 1 1 CD cord-300061-l2pfl776 67 61 3 3 CD cord-300061-l2pfl776 67 62 / / SYM cord-300061-l2pfl776 67 63 [ [ -LRB- cord-300061-l2pfl776 67 64 5 5 CD cord-300061-l2pfl776 67 65 ] ] -RRB- cord-300061-l2pfl776 67 66 . . . cord-300061-l2pfl776 68 1 Using use VBG cord-300061-l2pfl776 68 2 235 235 CD cord-300061-l2pfl776 68 3 bacterial bacterial JJ cord-300061-l2pfl776 68 4 genomes genome NNS cord-300061-l2pfl776 68 5 , , , cord-300061-l2pfl776 68 6 they -PRON- PRP cord-300061-l2pfl776 68 7 found find VBD cord-300061-l2pfl776 68 8 that that IN cord-300061-l2pfl776 68 9 the the DT cord-300061-l2pfl776 68 10 mapping mapping NN cord-300061-l2pfl776 68 11 points point NNS cord-300061-l2pfl776 68 12 of of IN cord-300061-l2pfl776 68 13 45 45 CD cord-300061-l2pfl776 68 14 % % NN cord-300061-l2pfl776 68 15 of of IN cord-300061-l2pfl776 68 16 these these DT cord-300061-l2pfl776 68 17 genomes genome NNS cord-300061-l2pfl776 68 18 were be VBD cord-300061-l2pfl776 68 19 outside outside IN cord-300061-l2pfl776 68 20 the the DT cord-300061-l2pfl776 68 21 inscribed inscribe VBN cord-300061-l2pfl776 68 22 sphere sphere NN cord-300061-l2pfl776 68 23 [ [ -LRB- cord-300061-l2pfl776 68 24 5 5 CD cord-300061-l2pfl776 68 25 ] ] -RRB- cord-300061-l2pfl776 68 26 . . . cord-300061-l2pfl776 69 1 Their -PRON- PRP$ cord-300061-l2pfl776 69 2 calculation calculation NN cord-300061-l2pfl776 69 3 is be VBZ cord-300061-l2pfl776 69 4 incorrect incorrect JJ cord-300061-l2pfl776 69 5 , , , cord-300061-l2pfl776 69 6 due due IN cord-300061-l2pfl776 69 7 to to IN cord-300061-l2pfl776 69 8 the the DT cord-300061-l2pfl776 69 9 neglect neglect NN cord-300061-l2pfl776 69 10 of of IN cord-300061-l2pfl776 69 11 a a DT cord-300061-l2pfl776 69 12 parameter parameter NN cord-300061-l2pfl776 69 13 , , , cord-300061-l2pfl776 69 14 as as IN cord-300061-l2pfl776 69 15 shown show VBN cord-300061-l2pfl776 69 16 below below RB cord-300061-l2pfl776 69 17 . . . cord-300061-l2pfl776 70 1 Letting let VBG cord-300061-l2pfl776 70 2 the the DT cord-300061-l2pfl776 70 3 nucleotide nucleotide JJ cord-300061-l2pfl776 70 4 frequencies frequency NNS cord-300061-l2pfl776 70 5 of of IN cord-300061-l2pfl776 70 6 A A NNP cord-300061-l2pfl776 70 7 , , , cord-300061-l2pfl776 70 8 C C NNP cord-300061-l2pfl776 70 9 , , , cord-300061-l2pfl776 70 10 G G NNP cord-300061-l2pfl776 70 11 and and CC cord-300061-l2pfl776 70 12 T T NNP cord-300061-l2pfl776 70 13 be be VBP cord-300061-l2pfl776 70 14 denoted denote VBN cord-300061-l2pfl776 70 15 by by IN cord-300061-l2pfl776 70 16 a a DT cord-300061-l2pfl776 70 17 , , , cord-300061-l2pfl776 70 18 c c NNP cord-300061-l2pfl776 70 19 , , , cord-300061-l2pfl776 70 20 g g NNP cord-300061-l2pfl776 70 21 and and CC cord-300061-l2pfl776 70 22 t t NN cord-300061-l2pfl776 70 23 , , , cord-300061-l2pfl776 70 24 respectively respectively RB cord-300061-l2pfl776 70 25 , , , cord-300061-l2pfl776 70 26 and and CC cord-300061-l2pfl776 70 27 taking take VBG cord-300061-l2pfl776 70 28 the the DT cord-300061-l2pfl776 70 29 center center NN cord-300061-l2pfl776 70 30 of of IN cord-300061-l2pfl776 70 31 the the DT cord-300061-l2pfl776 70 32 RT RT NNP cord-300061-l2pfl776 70 33 as as IN cord-300061-l2pfl776 70 34 the the DT cord-300061-l2pfl776 70 35 origin origin NN cord-300061-l2pfl776 70 36 , , , cord-300061-l2pfl776 70 37 a a DT cord-300061-l2pfl776 70 38 coordinate coordinate JJ cord-300061-l2pfl776 70 39 system system NN cord-300061-l2pfl776 70 40 ( ( -LRB- cord-300061-l2pfl776 70 41 X X NNS cord-300061-l2pfl776 70 42 , , , cord-300061-l2pfl776 70 43 Y Y NNP cord-300061-l2pfl776 70 44 , , , cord-300061-l2pfl776 70 45 Z Z NNP cord-300061-l2pfl776 70 46 ) ) -RRB- cord-300061-l2pfl776 70 47 can can MD cord-300061-l2pfl776 70 48 be be VB cord-300061-l2pfl776 70 49 set set VBN cord-300061-l2pfl776 70 50 up up RP cord-300061-l2pfl776 70 51 [ [ -LRB- cord-300061-l2pfl776 70 52 ( ( -LRB- cord-300061-l2pfl776 70 53 1 1 LS cord-300061-l2pfl776 70 54 ) ) -RRB- cord-300061-l2pfl776 70 55 where where WRB cord-300061-l2pfl776 70 56 X X NNP cord-300061-l2pfl776 70 57 , , , cord-300061-l2pfl776 70 58 Y Y NNP cord-300061-l2pfl776 70 59 and and CC cord-300061-l2pfl776 70 60 Z Z NNP cord-300061-l2pfl776 70 61 are be VBP cord-300061-l2pfl776 70 62 the the DT cord-300061-l2pfl776 70 63 coordinates coordinate NNS cord-300061-l2pfl776 70 64 of of IN cord-300061-l2pfl776 70 65 the the DT cord-300061-l2pfl776 70 66 mapping mapping NN cord-300061-l2pfl776 70 67 point point NN cord-300061-l2pfl776 70 68 P p NN cord-300061-l2pfl776 70 69 in in IN cord-300061-l2pfl776 70 70 this this DT cord-300061-l2pfl776 70 71 coordinate coordinate JJ cord-300061-l2pfl776 70 72 system system NN cord-300061-l2pfl776 70 73 . . . cord-300061-l2pfl776 71 1 For for IN cord-300061-l2pfl776 71 2 convenience convenience NN cord-300061-l2pfl776 71 3 , , , cord-300061-l2pfl776 71 4 we -PRON- PRP cord-300061-l2pfl776 71 5 introduced introduce VBD cord-300061-l2pfl776 71 6 a a DT cord-300061-l2pfl776 71 7 reduced reduce VBN cord-300061-l2pfl776 71 8 coordinate coordinate NN cord-300061-l2pfl776 71 9 system system NN cord-300061-l2pfl776 71 10 ( ( -LRB- cord-300061-l2pfl776 71 11 x x SYM cord-300061-l2pfl776 71 12 , , , cord-300061-l2pfl776 71 13 y y NNP cord-300061-l2pfl776 71 14 , , , cord-300061-l2pfl776 71 15 z z NNP cord-300061-l2pfl776 71 16 ) ) -RRB- cord-300061-l2pfl776 71 17 such such JJ cord-300061-l2pfl776 71 18 that that DT cord-300061-l2pfl776 72 1 ( ( -LRB- cord-300061-l2pfl776 72 2 refer refer VB cord-300061-l2pfl776 72 3 to to IN cord-300061-l2pfl776 72 4 the the DT cord-300061-l2pfl776 72 5 equation equation NN cord-300061-l2pfl776 72 6 ( ( -LRB- cord-300061-l2pfl776 72 7 3 3 CD cord-300061-l2pfl776 72 8 ) ) -RRB- cord-300061-l2pfl776 72 9 of of IN cord-300061-l2pfl776 72 10 the the DT cord-300061-l2pfl776 72 11 reference reference NN cord-300061-l2pfl776 72 12 [ [ -LRB- cord-300061-l2pfl776 72 13 1 1 CD cord-300061-l2pfl776 72 14 ] ] -RRB- cord-300061-l2pfl776 72 15 ) ) -RRB- cord-300061-l2pfl776 72 16 , , , cord-300061-l2pfl776 72 17 . . . cord-300061-l2pfl776 73 1 ( ( -LRB- cord-300061-l2pfl776 73 2 Then then RB cord-300061-l2pfl776 73 3 we -PRON- PRP cord-300061-l2pfl776 73 4 have have VBP cord-300061-l2pfl776 74 1 x x NFP cord-300061-l2pfl776 74 2 a a DT cord-300061-l2pfl776 74 3 g g NN cord-300061-l2pfl776 74 4 c c NN cord-300061-l2pfl776 74 5 t t NNP cord-300061-l2pfl776 74 6 y y NNP cord-300061-l2pfl776 74 7 a a DT cord-300061-l2pfl776 74 8 c c NN cord-300061-l2pfl776 74 9 g g NN cord-300061-l2pfl776 74 10 t t NN cord-300061-l2pfl776 74 11 z z NNP cord-300061-l2pfl776 74 12 a a DT cord-300061-l2pfl776 74 13 t t NN cord-300061-l2pfl776 75 1 g g NNP cord-300061-l2pfl776 75 2 c c NNP cord-300061-l2pfl776 75 3 x x SYM cord-300061-l2pfl776 75 4 y y NNP cord-300061-l2pfl776 75 5 z z NNP cord-300061-l2pfl776 75 6 Equation Equation NNP cord-300061-l2pfl776 75 7 ( ( -LRB- cord-300061-l2pfl776 75 8 3 3 CD cord-300061-l2pfl776 75 9 ) ) -RRB- cord-300061-l2pfl776 75 10 is be VBZ cord-300061-l2pfl776 75 11 the the DT cord-300061-l2pfl776 75 12 one one NN cord-300061-l2pfl776 75 13 that that WDT cord-300061-l2pfl776 75 14 has have VBZ cord-300061-l2pfl776 75 15 been be VBN cord-300061-l2pfl776 75 16 mostly mostly RB cord-300061-l2pfl776 75 17 used use VBN cord-300061-l2pfl776 75 18 in in IN cord-300061-l2pfl776 75 19 related related JJ cord-300061-l2pfl776 75 20 studies study NNS cord-300061-l2pfl776 75 21 . . . cord-300061-l2pfl776 76 1 Based base VBN cord-300061-l2pfl776 76 2 on on IN cord-300061-l2pfl776 76 3 equation equation NN cord-300061-l2pfl776 76 4 ( ( -LRB- cord-300061-l2pfl776 76 5 2 2 CD cord-300061-l2pfl776 76 6 ) ) -RRB- cord-300061-l2pfl776 76 7 , , , cord-300061-l2pfl776 76 8 where where WRB cord-300061-l2pfl776 76 9 R r NN cord-300061-l2pfl776 76 10 and and CC cord-300061-l2pfl776 76 11 r r NN cord-300061-l2pfl776 76 12 are be VBP cord-300061-l2pfl776 76 13 the the DT cord-300061-l2pfl776 76 14 radii radii NN cord-300061-l2pfl776 76 15 of of IN cord-300061-l2pfl776 76 16 the the DT cord-300061-l2pfl776 76 17 inscribed inscribe VBN cord-300061-l2pfl776 76 18 sphere sphere NN cord-300061-l2pfl776 76 19 in in IN cord-300061-l2pfl776 76 20 the the DT cord-300061-l2pfl776 76 21 original original JJ cord-300061-l2pfl776 76 22 ( ( -LRB- cord-300061-l2pfl776 76 23 X x NN cord-300061-l2pfl776 76 24 , , , cord-300061-l2pfl776 76 25 Y Y NNP cord-300061-l2pfl776 76 26 , , , cord-300061-l2pfl776 76 27 Z Z NNP cord-300061-l2pfl776 76 28 ) ) -RRB- cord-300061-l2pfl776 76 29 and and CC cord-300061-l2pfl776 76 30 the the DT cord-300061-l2pfl776 76 31 reduced reduce VBN cord-300061-l2pfl776 76 32 ( ( -LRB- cord-300061-l2pfl776 76 33 x x SYM cord-300061-l2pfl776 76 34 , , , cord-300061-l2pfl776 76 35 y y NNP cord-300061-l2pfl776 76 36 , , , cord-300061-l2pfl776 76 37 z z LS cord-300061-l2pfl776 76 38 ) ) -RRB- cord-300061-l2pfl776 76 39 coordinate coordinate VB cord-300061-l2pfl776 76 40 systems system NNS cord-300061-l2pfl776 76 41 , , , cord-300061-l2pfl776 76 42 respectively respectively RB cord-300061-l2pfl776 76 43 . . . cord-300061-l2pfl776 77 1 Therefore therefore RB cord-300061-l2pfl776 77 2 , , , cord-300061-l2pfl776 77 3 in in IN cord-300061-l2pfl776 77 4 the the DT cord-300061-l2pfl776 77 5 reduced reduce VBN cord-300061-l2pfl776 77 6 coordinate coordinate NN cord-300061-l2pfl776 77 7 system system NN cord-300061-l2pfl776 77 8 the the DT cord-300061-l2pfl776 77 9 radius radius NN cord-300061-l2pfl776 77 10 of of IN cord-300061-l2pfl776 77 11 the the DT cord-300061-l2pfl776 77 12 inscribed inscribe VBN cord-300061-l2pfl776 77 13 sphere sphere NN cord-300061-l2pfl776 77 14 is be VBZ cord-300061-l2pfl776 77 15 One one PRP cord-300061-l2pfl776 77 16 can can MD cord-300061-l2pfl776 77 17 use use VB cord-300061-l2pfl776 77 18 either either CC cord-300061-l2pfl776 77 19 the the DT cord-300061-l2pfl776 77 20 original original JJ cord-300061-l2pfl776 77 21 ( ( -LRB- cord-300061-l2pfl776 77 22 X x NN cord-300061-l2pfl776 77 23 , , , cord-300061-l2pfl776 77 24 Y Y NNP cord-300061-l2pfl776 77 25 , , , cord-300061-l2pfl776 77 26 Z Z NNP cord-300061-l2pfl776 77 27 ) ) -RRB- cord-300061-l2pfl776 77 28 or or CC cord-300061-l2pfl776 77 29 the the DT cord-300061-l2pfl776 77 30 reduced reduce VBN cord-300061-l2pfl776 77 31 coordinate coordinate NN cord-300061-l2pfl776 77 32 system system NN cord-300061-l2pfl776 77 33 ( ( -LRB- cord-300061-l2pfl776 78 1 x x NNP cord-300061-l2pfl776 78 2 , , , cord-300061-l2pfl776 78 3 y y NNP cord-300061-l2pfl776 78 4 , , , cord-300061-l2pfl776 78 5 z z NNP cord-300061-l2pfl776 78 6 ) ) -RRB- cord-300061-l2pfl776 78 7 , , , cord-300061-l2pfl776 78 8 but but CC cord-300061-l2pfl776 78 9 should should MD cord-300061-l2pfl776 78 10 use use VB cord-300061-l2pfl776 78 11 the the DT cord-300061-l2pfl776 78 12 corresponding corresponding JJ cord-300061-l2pfl776 78 13 radius radius NN cord-300061-l2pfl776 78 14 , , , cord-300061-l2pfl776 78 15 R r NN cord-300061-l2pfl776 78 16 ( ( -LRB- cord-300061-l2pfl776 78 17 1/4 1/4 CD cord-300061-l2pfl776 78 18 ) ) -RRB- cord-300061-l2pfl776 78 19 or or CC cord-300061-l2pfl776 78 20 ( ( -LRB- cord-300061-l2pfl776 78 21 1 1 CD cord-300061-l2pfl776 78 22 3 3 CD cord-300061-l2pfl776 78 23 / / SYM cord-300061-l2pfl776 78 24 ) ) -RRB- cord-300061-l2pfl776 78 25 , , , cord-300061-l2pfl776 78 26 for for IN cord-300061-l2pfl776 78 27 the the DT cord-300061-l2pfl776 78 28 former former JJ cord-300061-l2pfl776 78 29 and and CC cord-300061-l2pfl776 78 30 latter latter JJ cord-300061-l2pfl776 78 31 , , , cord-300061-l2pfl776 78 32 respectively respectively RB cord-300061-l2pfl776 78 33 . . . cord-300061-l2pfl776 79 1 Elhaik Elhaik NNP cord-300061-l2pfl776 79 2 et et NNP cord-300061-l2pfl776 79 3 al al NNP cord-300061-l2pfl776 79 4 . . . cord-300061-l2pfl776 80 1 used use VBD cord-300061-l2pfl776 80 2 the the DT cord-300061-l2pfl776 80 3 equation equation NN cord-300061-l2pfl776 80 4 ( ( -LRB- cord-300061-l2pfl776 80 5 3 3 CD cord-300061-l2pfl776 80 6 ) ) -RRB- cord-300061-l2pfl776 80 7 to to TO cord-300061-l2pfl776 80 8 obtain obtain VB cord-300061-l2pfl776 80 9 the the DT cord-300061-l2pfl776 80 10 coordinates coordinate NNS cord-300061-l2pfl776 80 11 in in IN cord-300061-l2pfl776 80 12 the the DT cord-300061-l2pfl776 80 13 reduced reduce VBN cord-300061-l2pfl776 80 14 coordinate coordinate NN cord-300061-l2pfl776 80 15 system system NN cord-300061-l2pfl776 80 16 ( ( -LRB- cord-300061-l2pfl776 80 17 x x SYM cord-300061-l2pfl776 80 18 , , , cord-300061-l2pfl776 80 19 y y NNP cord-300061-l2pfl776 80 20 , , , cord-300061-l2pfl776 80 21 z z NNP cord-300061-l2pfl776 80 22 ) ) -RRB- cord-300061-l2pfl776 80 23 , , , cord-300061-l2pfl776 80 24 but but CC cord-300061-l2pfl776 80 25 still still RB cord-300061-l2pfl776 80 26 used use VBN cord-300061-l2pfl776 80 27 R r NN cord-300061-l2pfl776 80 28 ( ( -LRB- cord-300061-l2pfl776 80 29 1/4 1/4 CD cord-300061-l2pfl776 80 30 ) ) -RRB- cord-300061-l2pfl776 80 31 , , , cord-300061-l2pfl776 80 32 the the DT cord-300061-l2pfl776 80 33 radius radius NN cord-300061-l2pfl776 80 34 in in IN cord-300061-l2pfl776 80 35 the the DT cord-300061-l2pfl776 80 36 original original JJ cord-300061-l2pfl776 80 37 system system NN cord-300061-l2pfl776 80 38 ( ( -LRB- cord-300061-l2pfl776 80 39 X X NNP cord-300061-l2pfl776 80 40 , , , cord-300061-l2pfl776 80 41 Y Y NNP cord-300061-l2pfl776 80 42 , , , cord-300061-l2pfl776 80 43 Z Z NNP cord-300061-l2pfl776 80 44 ) ) -RRB- cord-300061-l2pfl776 80 45 [ [ -LRB- cord-300061-l2pfl776 80 46 5 5 CD cord-300061-l2pfl776 80 47 ] ] -RRB- cord-300061-l2pfl776 80 48 . . . cord-300061-l2pfl776 81 1 In in IN cord-300061-l2pfl776 81 2 other other JJ cord-300061-l2pfl776 81 3 words word NNS cord-300061-l2pfl776 81 4 , , , cord-300061-l2pfl776 81 5 their -PRON- PRP$ cord-300061-l2pfl776 81 6 mistake mistake NN cord-300061-l2pfl776 81 7 is be VBZ cord-300061-l2pfl776 81 8 due due JJ cord-300061-l2pfl776 81 9 to to IN cord-300061-l2pfl776 81 10 the the DT cord-300061-l2pfl776 81 11 confusion confusion NN cord-300061-l2pfl776 81 12 of of IN cord-300061-l2pfl776 81 13 the the DT cord-300061-l2pfl776 81 14 original original JJ cord-300061-l2pfl776 81 15 and and CC cord-300061-l2pfl776 81 16 reduced reduced JJ cord-300061-l2pfl776 81 17 coordinate coordinate JJ cord-300061-l2pfl776 81 18 systems system NNS cord-300061-l2pfl776 81 19 . . . cord-300061-l2pfl776 82 1 Figure figure NN cord-300061-l2pfl776 82 2 1 1 CD cord-300061-l2pfl776 82 3 shows show VBZ cord-300061-l2pfl776 82 4 the the DT cord-300061-l2pfl776 82 5 distribution distribution NN cord-300061-l2pfl776 82 6 of of IN cord-300061-l2pfl776 82 7 the the DT cord-300061-l2pfl776 82 8 mapping mapping NN cord-300061-l2pfl776 82 9 points point NNS cord-300061-l2pfl776 82 10 of of IN cord-300061-l2pfl776 82 11 the the DT cord-300061-l2pfl776 82 12 235 235 CD cord-300061-l2pfl776 82 13 bacterial bacterial JJ cord-300061-l2pfl776 82 14 genomes genome NNS cord-300061-l2pfl776 82 15 used use VBN cord-300061-l2pfl776 82 16 in in IN cord-300061-l2pfl776 82 17 [ [ -LRB- cord-300061-l2pfl776 82 18 5 5 CD cord-300061-l2pfl776 82 19 ] ] -RRB- cord-300061-l2pfl776 82 20 . . . cord-300061-l2pfl776 83 1 Based base VBN cord-300061-l2pfl776 83 2 on on IN cord-300061-l2pfl776 83 3 the the DT cord-300061-l2pfl776 83 4 correct correct JJ cord-300061-l2pfl776 83 5 radius radius NN cord-300061-l2pfl776 83 6 , , , cord-300061-l2pfl776 83 7 in in IN cord-300061-l2pfl776 83 8 contrast contrast NN cord-300061-l2pfl776 83 9 to to IN cord-300061-l2pfl776 83 10 their -PRON- PRP$ cord-300061-l2pfl776 83 11 conclusion conclusion NN cord-300061-l2pfl776 83 12 that that IN cord-300061-l2pfl776 83 13 45 45 CD cord-300061-l2pfl776 83 14 % % NN cord-300061-l2pfl776 83 15 of of IN cord-300061-l2pfl776 83 16 genomes genome NNS cord-300061-l2pfl776 83 17 have have VBP cord-300061-l2pfl776 83 18 mapping mapping NN cord-300061-l2pfl776 83 19 points point NNS cord-300061-l2pfl776 83 20 outside outside IN cord-300061-l2pfl776 83 21 the the DT cord-300061-l2pfl776 83 22 inscribed inscribe VBN cord-300061-l2pfl776 83 23 sphere sphere NN cord-300061-l2pfl776 83 24 , , , cord-300061-l2pfl776 83 25 none none NN cord-300061-l2pfl776 83 26 has have VBZ cord-300061-l2pfl776 83 27 the the DT cord-300061-l2pfl776 83 28 mapping mapping NN cord-300061-l2pfl776 83 29 point point NN cord-300061-l2pfl776 83 30 outside outside IN cord-300061-l2pfl776 83 31 the the DT cord-300061-l2pfl776 83 32 inscribed inscribe VBN cord-300061-l2pfl776 83 33 sphere sphere NN cord-300061-l2pfl776 83 34 and and CC cord-300061-l2pfl776 83 35 none none NN cord-300061-l2pfl776 83 36 has have VBZ cord-300061-l2pfl776 83 37 an an DT cord-300061-l2pfl776 83 38 S S NNP cord-300061-l2pfl776 83 39 value value NN cord-300061-l2pfl776 83 40 larger large JJR cord-300061-l2pfl776 83 41 than than IN cord-300061-l2pfl776 83 42 1/3 1/3 CD cord-300061-l2pfl776 83 43 . . . cord-300061-l2pfl776 84 1 Therefore therefore RB cord-300061-l2pfl776 84 2 it -PRON- PRP cord-300061-l2pfl776 84 3 is be VBZ cord-300061-l2pfl776 84 4 the the DT cord-300061-l2pfl776 84 5 inscribed inscribe VBN cord-300061-l2pfl776 84 6 sphere sphere NN cord-300061-l2pfl776 84 7 , , , cord-300061-l2pfl776 84 8 as as IN cord-300061-l2pfl776 84 9 correctly correctly RB cord-300061-l2pfl776 84 10 indicated indicate VBN cord-300061-l2pfl776 84 11 in in IN cord-300061-l2pfl776 84 12 the the DT cord-300061-l2pfl776 84 13 original original JJ cord-300061-l2pfl776 84 14 article article NN cord-300061-l2pfl776 84 15 [ [ -LRB- cord-300061-l2pfl776 84 16 2 2 CD cord-300061-l2pfl776 84 17 ] ] -RRB- cord-300061-l2pfl776 84 18 . . . cord-300061-l2pfl776 85 1 The the DT cord-300061-l2pfl776 85 2 mistake mistake NN cord-300061-l2pfl776 85 3 of of IN cord-300061-l2pfl776 85 4 Elhaik Elhaik NNP cord-300061-l2pfl776 85 5 et et NNP cord-300061-l2pfl776 85 6 al al NNP cord-300061-l2pfl776 85 7 . . . cord-300061-l2pfl776 86 1 is be VBZ cord-300061-l2pfl776 86 2 the the DT cord-300061-l2pfl776 86 3 confusion confusion NN cord-300061-l2pfl776 86 4 of of IN cord-300061-l2pfl776 86 5 the the DT cord-300061-l2pfl776 86 6 original original JJ cord-300061-l2pfl776 86 7 and and CC cord-300061-l2pfl776 86 8 reduced reduced JJ cord-300061-l2pfl776 86 9 coordinate coordinate JJ cord-300061-l2pfl776 86 10 systems system NNS cord-300061-l2pfl776 86 11 , , , cord-300061-l2pfl776 86 12 and and CC cord-300061-l2pfl776 86 13 consequently consequently RB cord-300061-l2pfl776 86 14 , , , cord-300061-l2pfl776 86 15 the the DT cord-300061-l2pfl776 86 16 neglect neglect NN cord-300061-l2pfl776 86 17 of of IN cord-300061-l2pfl776 86 18 the the DT cord-300061-l2pfl776 86 19 parameter parameter NN cord-300061-l2pfl776 86 20 4 4 CD cord-300061-l2pfl776 86 21 3 3 CD cord-300061-l2pfl776 86 22 / / SYM cord-300061-l2pfl776 86 23 . . . cord-300061-l2pfl776 87 1 In in IN cord-300061-l2pfl776 87 2 this this DT cord-300061-l2pfl776 87 3 section section NN cord-300061-l2pfl776 87 4 , , , cord-300061-l2pfl776 87 5 Elhaik Elhaik NNP cord-300061-l2pfl776 87 6 et et NNP cord-300061-l2pfl776 87 7 al al NNP cord-300061-l2pfl776 87 8 . . . cord-300061-l2pfl776 88 1 first first RB cord-300061-l2pfl776 88 2 " " `` cord-300061-l2pfl776 88 3 found find VBD cord-300061-l2pfl776 88 4 that that IN cord-300061-l2pfl776 88 5 the the DT cord-300061-l2pfl776 88 6 distribution distribution NN cord-300061-l2pfl776 88 7 of of IN cord-300061-l2pfl776 88 8 S S NNP cord-300061-l2pfl776 88 9 values value NNS cord-300061-l2pfl776 88 10 follows follow VBZ cord-300061-l2pfl776 88 11 an an DT cord-300061-l2pfl776 88 12 exponential exponential JJ cord-300061-l2pfl776 88 13 distribution distribution NN cord-300061-l2pfl776 88 14 " " '' cord-300061-l2pfl776 88 15 . . . cord-300061-l2pfl776 89 1 This this DT cord-300061-l2pfl776 89 2 is be VBZ cord-300061-l2pfl776 89 3 a a DT cord-300061-l2pfl776 89 4 restatement restatement NN cord-300061-l2pfl776 89 5 of of IN cord-300061-l2pfl776 89 6 our -PRON- PRP$ cord-300061-l2pfl776 89 7 previous previous JJ cord-300061-l2pfl776 89 8 conclusion conclusion NN cord-300061-l2pfl776 89 9 [ [ -LRB- cord-300061-l2pfl776 89 10 2 2 CD cord-300061-l2pfl776 89 11 ] ] -RRB- cord-300061-l2pfl776 89 12 , , , cord-300061-l2pfl776 89 13 albeit albeit IN cord-300061-l2pfl776 89 14 with with IN cord-300061-l2pfl776 89 15 less less JJR cord-300061-l2pfl776 89 16 data datum NNS cord-300061-l2pfl776 89 17 . . . cord-300061-l2pfl776 90 1 Compare compare VB cord-300061-l2pfl776 90 2 the the DT cord-300061-l2pfl776 90 3 figure figure NN cord-300061-l2pfl776 90 4 2 2 CD cord-300061-l2pfl776 90 5 in in IN cord-300061-l2pfl776 90 6 [ [ -LRB- cord-300061-l2pfl776 90 7 2 2 CD cord-300061-l2pfl776 90 8 ] ] -RRB- cord-300061-l2pfl776 90 9 and and CC cord-300061-l2pfl776 90 10 the the DT cord-300061-l2pfl776 90 11 figure figure NN cord-300061-l2pfl776 90 12 2 2 CD cord-300061-l2pfl776 90 13 in in IN cord-300061-l2pfl776 90 14 [ [ -LRB- cord-300061-l2pfl776 90 15 5 5 CD cord-300061-l2pfl776 90 16 ] ] -RRB- cord-300061-l2pfl776 90 17 ; ; : cord-300061-l2pfl776 90 18 in in IN cord-300061-l2pfl776 90 19 the the DT cord-300061-l2pfl776 90 20 former former JJ cord-300061-l2pfl776 90 21 more more JJR cord-300061-l2pfl776 90 22 than than IN cord-300061-l2pfl776 90 23 800 800 CD cord-300061-l2pfl776 90 24 genomes genome NNS cord-300061-l2pfl776 90 25 of of IN cord-300061-l2pfl776 90 26 multiple multiple JJ cord-300061-l2pfl776 90 27 species specie NNS cord-300061-l2pfl776 90 28 were be VBD cord-300061-l2pfl776 90 29 studied study VBN cord-300061-l2pfl776 90 30 , , , cord-300061-l2pfl776 90 31 while while IN cord-300061-l2pfl776 90 32 in in IN cord-300061-l2pfl776 90 33 the the DT cord-300061-l2pfl776 90 34 latter latter JJ cord-300061-l2pfl776 90 35 , , , cord-300061-l2pfl776 90 36 only only RB cord-300061-l2pfl776 90 37 235 235 CD cord-300061-l2pfl776 90 38 bacterial bacterial JJ cord-300061-l2pfl776 90 39 genomes genome NNS cord-300061-l2pfl776 90 40 were be VBD cord-300061-l2pfl776 90 41 used use VBN cord-300061-l2pfl776 90 42 . . . cord-300061-l2pfl776 91 1 Elhaik Elhaik NNP cord-300061-l2pfl776 91 2 et et NNP cord-300061-l2pfl776 91 3 al al NNP cord-300061-l2pfl776 91 4 . . . cord-300061-l2pfl776 92 1 then then RB cord-300061-l2pfl776 92 2 found find VBD cord-300061-l2pfl776 92 3 that that IN cord-300061-l2pfl776 92 4 S S NNP cord-300061-l2pfl776 92 5 is be VBZ cord-300061-l2pfl776 92 6 narrowly narrowly RB cord-300061-l2pfl776 92 7 distributed distribute VBN cord-300061-l2pfl776 92 8 with with IN cord-300061-l2pfl776 92 9 a a DT cord-300061-l2pfl776 92 10 range range NN cord-300061-l2pfl776 92 11 of of IN cord-300061-l2pfl776 92 12 ( ( -LRB- cord-300061-l2pfl776 92 13 0.25 0.25 CD cord-300061-l2pfl776 92 14 -0.33 -0.33 CD cord-300061-l2pfl776 92 15 ) ) -RRB- cord-300061-l2pfl776 92 16 , , , cord-300061-l2pfl776 92 17 which which WDT cord-300061-l2pfl776 92 18 only only RB cord-300061-l2pfl776 92 19 paraphrased paraphrase VBD cord-300061-l2pfl776 92 20 our -PRON- PRP$ cord-300061-l2pfl776 92 21 previously previously RB cord-300061-l2pfl776 92 22 suggested suggest VBN cord-300061-l2pfl776 92 23 S S NNP cord-300061-l2pfl776 92 24 range range NN cord-300061-l2pfl776 92 25 ( ( -LRB- cord-300061-l2pfl776 92 26 0.25 0.25 CD cord-300061-l2pfl776 92 27 -1/3 -1/3 NN cord-300061-l2pfl776 92 28 ) ) -RRB- cord-300061-l2pfl776 93 1 [ [ -LRB- cord-300061-l2pfl776 93 2 2 2 CD cord-300061-l2pfl776 93 3 ] ] -RRB- cord-300061-l2pfl776 93 4 . . . cord-300061-l2pfl776 94 1 Is be VBZ cord-300061-l2pfl776 94 2 S S NNP cord-300061-l2pfl776 94 3 equivalent equivalent JJ cord-300061-l2pfl776 94 4 to to IN cord-300061-l2pfl776 94 5 H h NN cord-300061-l2pfl776 94 6 ? ? . cord-300061-l2pfl776 95 1 In in IN cord-300061-l2pfl776 95 2 2005 2005 CD cord-300061-l2pfl776 95 3 [ [ -LRB- cord-300061-l2pfl776 95 4 6 6 CD cord-300061-l2pfl776 95 5 ] ] -RRB- cord-300061-l2pfl776 95 6 , , , cord-300061-l2pfl776 95 7 we -PRON- PRP cord-300061-l2pfl776 95 8 proposed propose VBD cord-300061-l2pfl776 95 9 a a DT cord-300061-l2pfl776 95 10 new new JJ cord-300061-l2pfl776 95 11 algorithm algorithm NN cord-300061-l2pfl776 95 12 for for IN cord-300061-l2pfl776 95 13 genome genome NN cord-300061-l2pfl776 95 14 segmentation segmentation NN cord-300061-l2pfl776 95 15 , , , cord-300061-l2pfl776 95 16 and and CC cord-300061-l2pfl776 95 17 we -PRON- PRP cord-300061-l2pfl776 95 18 indicated indicate VBD cord-300061-l2pfl776 95 19 that that IN cord-300061-l2pfl776 95 20 the the DT cord-300061-l2pfl776 95 21 algorithms algorithm NNS cord-300061-l2pfl776 95 22 based base VBN cord-300061-l2pfl776 95 23 on on IN cord-300061-l2pfl776 95 24 either either DT cord-300061-l2pfl776 95 25 S S NNP cord-300061-l2pfl776 95 26 or or CC cord-300061-l2pfl776 95 27 H H NNP cord-300061-l2pfl776 95 28 are be VBP cord-300061-l2pfl776 95 29 equivalent equivalent JJ cord-300061-l2pfl776 95 30 in in IN cord-300061-l2pfl776 95 31 obtaining obtain VBG cord-300061-l2pfl776 95 32 segmentation segmentation NN cord-300061-l2pfl776 95 33 points point NNS cord-300061-l2pfl776 95 34 for for IN cord-300061-l2pfl776 95 35 binary binary JJ cord-300061-l2pfl776 95 36 sequences sequence NNS cord-300061-l2pfl776 95 37 composed compose VBN cord-300061-l2pfl776 95 38 of of IN cord-300061-l2pfl776 95 39 two two CD cord-300061-l2pfl776 95 40 nucleotide nucleotide JJ cord-300061-l2pfl776 95 41 types type NNS cord-300061-l2pfl776 95 42 , , , cord-300061-l2pfl776 95 43 A A NNP cord-300061-l2pfl776 95 44 / / SYM cord-300061-l2pfl776 95 45 T T NNP cord-300061-l2pfl776 95 46 and and CC cord-300061-l2pfl776 95 47 G G NNP cord-300061-l2pfl776 95 48 / / SYM cord-300061-l2pfl776 95 49 C c NN cord-300061-l2pfl776 95 50 bases basis NNS cord-300061-l2pfl776 95 51 . . . cord-300061-l2pfl776 96 1 Note note VB cord-300061-l2pfl776 96 2 that that IN cord-300061-l2pfl776 96 3 here here RB cord-300061-l2pfl776 96 4 the the DT cord-300061-l2pfl776 96 5 word word NN cord-300061-l2pfl776 96 6 " " `` cord-300061-l2pfl776 96 7 equivalent equivalent JJ cord-300061-l2pfl776 96 8 " " '' cord-300061-l2pfl776 96 9 has have VBZ cord-300061-l2pfl776 96 10 a a DT cord-300061-l2pfl776 96 11 context context NN cord-300061-l2pfl776 96 12 , , , cord-300061-l2pfl776 96 13 that that RB cord-300061-l2pfl776 96 14 is is RB cord-300061-l2pfl776 96 15 , , , cord-300061-l2pfl776 96 16 in in IN cord-300061-l2pfl776 96 17 a a DT cord-300061-l2pfl776 96 18 specific specific JJ cord-300061-l2pfl776 96 19 application application NN cord-300061-l2pfl776 96 20 ( ( -LRB- cord-300061-l2pfl776 96 21 genome genome NN cord-300061-l2pfl776 96 22 segmentation segmentation NN cord-300061-l2pfl776 96 23 for for IN cord-300061-l2pfl776 96 24 binary binary JJ cord-300061-l2pfl776 96 25 sequences sequence NNS cord-300061-l2pfl776 96 26 ) ) -RRB- cord-300061-l2pfl776 96 27 with with IN cord-300061-l2pfl776 96 28 a a DT cord-300061-l2pfl776 96 29 specific specific JJ cord-300061-l2pfl776 96 30 algorithm algorithm NN cord-300061-l2pfl776 96 31 that that WDT cord-300061-l2pfl776 96 32 we -PRON- PRP cord-300061-l2pfl776 96 33 proposed propose VBD cord-300061-l2pfl776 96 34 , , , cord-300061-l2pfl776 96 35 and and CC cord-300061-l2pfl776 96 36 it -PRON- PRP cord-300061-l2pfl776 96 37 does do VBZ cord-300061-l2pfl776 96 38 not not RB cord-300061-l2pfl776 96 39 mean mean VB cord-300061-l2pfl776 96 40 S S NNP cord-300061-l2pfl776 96 41 and and CC cord-300061-l2pfl776 96 42 H H NNP cord-300061-l2pfl776 96 43 are be VBP cord-300061-l2pfl776 96 44 equivalent equivalent JJ cord-300061-l2pfl776 96 45 . . . cord-300061-l2pfl776 97 1 In in IN cord-300061-l2pfl776 97 2 their -PRON- PRP$ cord-300061-l2pfl776 97 3 first first JJ cord-300061-l2pfl776 97 4 comment comment NN cord-300061-l2pfl776 97 5 [ [ -LRB- cord-300061-l2pfl776 97 6 3 3 CD cord-300061-l2pfl776 97 7 ] ] -RRB- cord-300061-l2pfl776 97 8 , , , cord-300061-l2pfl776 97 9 Elhaik Elhaik NNP cord-300061-l2pfl776 97 10 et et NNP cord-300061-l2pfl776 97 11 al al NNP cord-300061-l2pfl776 97 12 . . . cord-300061-l2pfl776 97 13 extrapolated extrapolate VBD cord-300061-l2pfl776 97 14 this this DT cord-300061-l2pfl776 97 15 conclusion conclusion NN cord-300061-l2pfl776 97 16 , , , cord-300061-l2pfl776 97 17 without without IN cord-300061-l2pfl776 97 18 any any DT cord-300061-l2pfl776 97 19 proof proof NN cord-300061-l2pfl776 97 20 , , , cord-300061-l2pfl776 97 21 claiming claim VBG cord-300061-l2pfl776 97 22 that that IN cord-300061-l2pfl776 97 23 , , , cord-300061-l2pfl776 97 24 " " `` cord-300061-l2pfl776 97 25 S s NN cord-300061-l2pfl776 97 26 is be VBZ cord-300061-l2pfl776 97 27 strictly strictly RB cord-300061-l2pfl776 97 28 equivalent equivalent JJ cord-300061-l2pfl776 97 29 to to IN cord-300061-l2pfl776 97 30 H H NNP cord-300061-l2pfl776 97 31 " " '' cord-300061-l2pfl776 97 32 , , , cord-300061-l2pfl776 97 33 which which WDT cord-300061-l2pfl776 97 34 is be VBZ cord-300061-l2pfl776 97 35 incorrect incorrect JJ cord-300061-l2pfl776 97 36 as as IN cord-300061-l2pfl776 97 37 one one CD cord-300061-l2pfl776 97 38 counterexample counterexample NN cord-300061-l2pfl776 97 39 was be VBD cord-300061-l2pfl776 97 40 enough enough JJ cord-300061-l2pfl776 97 41 to to TO cord-300061-l2pfl776 97 42 show show VB cord-300061-l2pfl776 97 43 they -PRON- PRP cord-300061-l2pfl776 97 44 are be VBP cord-300061-l2pfl776 97 45 not not RB cord-300061-l2pfl776 97 46 equivalent equivalent JJ cord-300061-l2pfl776 98 1 ( ( -LRB- cord-300061-l2pfl776 98 2 Only only RB cord-300061-l2pfl776 98 3 H H NNP cord-300061-l2pfl776 98 4 has have VBZ cord-300061-l2pfl776 98 5 the the DT cord-300061-l2pfl776 98 6 property property NN cord-300061-l2pfl776 98 7 of of IN cord-300061-l2pfl776 98 8 additivity additivity NN cord-300061-l2pfl776 98 9 of of IN cord-300061-l2pfl776 98 10 information information NN cord-300061-l2pfl776 98 11 entropy entropy NN cord-300061-l2pfl776 98 12 ) ) -RRB- cord-300061-l2pfl776 99 1 [ [ -LRB- cord-300061-l2pfl776 99 2 4 4 CD cord-300061-l2pfl776 99 3 ] ] -RRB- cord-300061-l2pfl776 99 4 . . . cord-300061-l2pfl776 100 1 In in IN cord-300061-l2pfl776 100 2 [ [ -LRB- cord-300061-l2pfl776 100 3 5 5 CD cord-300061-l2pfl776 100 4 ] ] -RRB- cord-300061-l2pfl776 100 5 , , , cord-300061-l2pfl776 100 6 they -PRON- PRP cord-300061-l2pfl776 100 7 claimed claim VBD cord-300061-l2pfl776 100 8 to to TO cord-300061-l2pfl776 100 9 have have VB cord-300061-l2pfl776 100 10 demonstrated demonstrate VBN cord-300061-l2pfl776 100 11 " " `` cord-300061-l2pfl776 100 12 S S NNP cord-300061-l2pfl776 100 13 is be VBZ cord-300061-l2pfl776 100 14 equivalent equivalent JJ cord-300061-l2pfl776 100 15 to to IN cord-300061-l2pfl776 100 16 H H NNP cord-300061-l2pfl776 100 17 " " '' cord-300061-l2pfl776 100 18 , , , cord-300061-l2pfl776 100 19 and and CC cord-300061-l2pfl776 100 20 " " `` cord-300061-l2pfl776 100 21 S s NN cord-300061-l2pfl776 100 22 is be VBZ cord-300061-l2pfl776 100 23 completely completely RB cord-300061-l2pfl776 100 24 determined determined JJ cord-300061-l2pfl776 100 25 from from IN cord-300061-l2pfl776 100 26 the the DT cord-300061-l2pfl776 100 27 [ [ -LRB- cord-300061-l2pfl776 100 28 Shannon Shannon NNP cord-300061-l2pfl776 100 29 ] ] -RRB- cord-300061-l2pfl776 100 30 entropy entropy NN cord-300061-l2pfl776 100 31 " " '' cord-300061-l2pfl776 100 32 . . . cord-300061-l2pfl776 101 1 Their -PRON- PRP$ cord-300061-l2pfl776 101 2 demonstration demonstration NN cord-300061-l2pfl776 101 3 is be VBZ cord-300061-l2pfl776 101 4 under under IN cord-300061-l2pfl776 101 5 the the DT cord-300061-l2pfl776 101 6 assumption assumption NN cord-300061-l2pfl776 101 7 that that IN cord-300061-l2pfl776 101 8 in in IN cord-300061-l2pfl776 101 9 a a DT cord-300061-l2pfl776 101 10 DNA dna NN cord-300061-l2pfl776 101 11 sequence sequence NN cord-300061-l2pfl776 101 12 , , , cord-300061-l2pfl776 101 13 a a DT cord-300061-l2pfl776 101 14 = = SYM cord-300061-l2pfl776 101 15 t t NN cord-300061-l2pfl776 101 16 and and CC cord-300061-l2pfl776 101 17 g g NN cord-300061-l2pfl776 101 18 = = SYM cord-300061-l2pfl776 101 19 c c NN cord-300061-l2pfl776 101 20 ( ( -LRB- cord-300061-l2pfl776 101 21 eq eq NNP cord-300061-l2pfl776 101 22 . . . cord-300061-l2pfl776 101 23 A1 A1 NNP cord-300061-l2pfl776 101 24 ) ) -RRB- cord-300061-l2pfl776 101 25 , , , cord-300061-l2pfl776 101 26 and and CC cord-300061-l2pfl776 101 27 a a DT cord-300061-l2pfl776 101 28 + + SYM cord-300061-l2pfl776 101 29 c c NN cord-300061-l2pfl776 101 30 = = SYM cord-300061-l2pfl776 101 31 0.5 0.5 CD cord-300061-l2pfl776 101 32 ( ( -LRB- cord-300061-l2pfl776 101 33 eq eq NNP cord-300061-l2pfl776 101 34 . . . cord-300061-l2pfl776 101 35 A2 A2 NNP cord-300061-l2pfl776 101 36 ) ) -RRB- cord-300061-l2pfl776 101 37 , , , cord-300061-l2pfl776 101 38 and and CC cord-300061-l2pfl776 101 39 consequently consequently RB cord-300061-l2pfl776 101 40 , , , cord-300061-l2pfl776 101 41 S S NNP cord-300061-l2pfl776 101 42 and and CC cord-300061-l2pfl776 101 43 H H NNP cord-300061-l2pfl776 101 44 , , , cord-300061-l2pfl776 101 45 both both DT cord-300061-l2pfl776 101 46 having have VBG cord-300061-l2pfl776 101 47 4 4 CD cord-300061-l2pfl776 101 48 variables variable NNS cord-300061-l2pfl776 101 49 , , , cord-300061-l2pfl776 101 50 a a NN cord-300061-l2pfl776 101 51 , , , cord-300061-l2pfl776 101 52 c c NNP cord-300061-l2pfl776 101 53 , , , cord-300061-l2pfl776 101 54 g g NNP cord-300061-l2pfl776 101 55 and and CC cord-300061-l2pfl776 101 56 t t NN cord-300061-l2pfl776 101 57 , , , cord-300061-l2pfl776 101 58 were be VBD cord-300061-l2pfl776 101 59 reduced reduce VBN cord-300061-l2pfl776 101 60 into into IN cord-300061-l2pfl776 101 61 functions function NNS cord-300061-l2pfl776 101 62 of of IN cord-300061-l2pfl776 101 63 one one CD cord-300061-l2pfl776 101 64 single single JJ cord-300061-l2pfl776 101 65 variable variable NN cord-300061-l2pfl776 101 66 , , , cord-300061-l2pfl776 101 67 a a DT cord-300061-l2pfl776 101 68 only only JJ cord-300061-l2pfl776 101 69 ( ( -LRB- cord-300061-l2pfl776 101 70 eq eq NN cord-300061-l2pfl776 101 71 . . . cord-300061-l2pfl776 101 72 A3 A3 NNP cord-300061-l2pfl776 101 73 ) ) -RRB- cord-300061-l2pfl776 101 74 . . . cord-300061-l2pfl776 102 1 This this DT cord-300061-l2pfl776 102 2 demonstration demonstration NN cord-300061-l2pfl776 102 3 is be VBZ cord-300061-l2pfl776 102 4 invalid invalid JJ cord-300061-l2pfl776 102 5 . . . cord-300061-l2pfl776 103 1 First first RB cord-300061-l2pfl776 103 2 , , , cord-300061-l2pfl776 103 3 S S NNP cord-300061-l2pfl776 103 4 is be VBZ cord-300061-l2pfl776 103 5 used use VBN cord-300061-l2pfl776 103 6 to to TO cord-300061-l2pfl776 103 7 study study VB cord-300061-l2pfl776 103 8 any any DT cord-300061-l2pfl776 103 9 DNA dna NN cord-300061-l2pfl776 103 10 sequences sequence NNS cord-300061-l2pfl776 103 11 , , , cord-300061-l2pfl776 103 12 not not RB cord-300061-l2pfl776 103 13 necessarily necessarily RB cord-300061-l2pfl776 103 14 only only RB cord-300061-l2pfl776 103 15 whole whole JJ cord-300061-l2pfl776 103 16 genomes genome NNS cord-300061-l2pfl776 103 17 . . . cord-300061-l2pfl776 104 1 For for IN cord-300061-l2pfl776 104 2 instance instance NN cord-300061-l2pfl776 104 3 , , , cord-300061-l2pfl776 104 4 to to TO cord-300061-l2pfl776 104 5 perform perform VB cord-300061-l2pfl776 104 6 genome genome NN cord-300061-l2pfl776 104 7 segmentation segmentation NN cord-300061-l2pfl776 104 8 studies study NNS cord-300061-l2pfl776 104 9 , , , cord-300061-l2pfl776 104 10 S S NNP cord-300061-l2pfl776 104 11 can can MD cord-300061-l2pfl776 104 12 be be VB cord-300061-l2pfl776 104 13 calculated calculate VBN cord-300061-l2pfl776 104 14 for for IN cord-300061-l2pfl776 104 15 sequences sequence NNS cord-300061-l2pfl776 104 16 shorter short JJR cord-300061-l2pfl776 104 17 than than IN cord-300061-l2pfl776 104 18 1 1 CD cord-300061-l2pfl776 104 19 Kb Kb NNP cord-300061-l2pfl776 104 20 [ [ -LRB- cord-300061-l2pfl776 104 21 6 6 CD cord-300061-l2pfl776 104 22 ] ] -RRB- cord-300061-l2pfl776 104 23 . . . cord-300061-l2pfl776 105 1 In in IN cord-300061-l2pfl776 105 2 [ [ -LRB- cord-300061-l2pfl776 105 3 1 1 CD cord-300061-l2pfl776 105 4 ] ] -RRB- cord-300061-l2pfl776 105 5 , , , cord-300061-l2pfl776 105 6 S S NNP cord-300061-l2pfl776 105 7 of of IN cord-300061-l2pfl776 105 8 protein protein NN cord-300061-l2pfl776 105 9 coding coding NN cord-300061-l2pfl776 105 10 genes gene NNS cord-300061-l2pfl776 105 11 was be VBD cord-300061-l2pfl776 105 12 studied study VBN cord-300061-l2pfl776 105 13 . . . cord-300061-l2pfl776 106 1 For for IN cord-300061-l2pfl776 106 2 single single JJ cord-300061-l2pfl776 106 3 genes gene NNS cord-300061-l2pfl776 106 4 or or CC cord-300061-l2pfl776 106 5 DNA dna NN cord-300061-l2pfl776 106 6 sequence sequence NN cord-300061-l2pfl776 106 7 segments segment NNS cord-300061-l2pfl776 106 8 , , , cord-300061-l2pfl776 106 9 not not RB cord-300061-l2pfl776 106 10 necessarily necessarily RB cord-300061-l2pfl776 106 11 , , , cord-300061-l2pfl776 106 12 base base NN cord-300061-l2pfl776 106 13 compositions composition NNS cord-300061-l2pfl776 106 14 of of IN cord-300061-l2pfl776 106 15 A a NN cord-300061-l2pfl776 106 16 and and CC cord-300061-l2pfl776 106 17 T T NNP cord-300061-l2pfl776 106 18 ( ( -LRB- cord-300061-l2pfl776 106 19 or or CC cord-300061-l2pfl776 106 20 C C NNP cord-300061-l2pfl776 106 21 and and CC cord-300061-l2pfl776 106 22 G G NNP cord-300061-l2pfl776 106 23 ) ) -RRB- cord-300061-l2pfl776 106 24 are be VBP cord-300061-l2pfl776 106 25 exactly exactly RB cord-300061-l2pfl776 106 26 the the DT cord-300061-l2pfl776 106 27 same same JJ cord-300061-l2pfl776 106 28 , , , cord-300061-l2pfl776 106 29 and and CC cord-300061-l2pfl776 106 30 the the DT cord-300061-l2pfl776 106 31 sum sum NN cord-300061-l2pfl776 106 32 of of IN cord-300061-l2pfl776 106 33 A A NNP cord-300061-l2pfl776 106 34 and and CC cord-300061-l2pfl776 106 35 C C NNP cord-300061-l2pfl776 106 36 is be VBZ cord-300061-l2pfl776 106 37 exactly exactly RB cord-300061-l2pfl776 106 38 50 50 CD cord-300061-l2pfl776 106 39 % % NN cord-300061-l2pfl776 106 40 ( ( -LRB- cord-300061-l2pfl776 106 41 eq eq NNP cord-300061-l2pfl776 106 42 . . . cord-300061-l2pfl776 106 43 A1 A1 NNP cord-300061-l2pfl776 106 44 and and CC cord-300061-l2pfl776 106 45 A2 A2 NNP cord-300061-l2pfl776 106 46 ) ) -RRB- cord-300061-l2pfl776 106 47 . . . cord-300061-l2pfl776 107 1 That that RB cord-300061-l2pfl776 107 2 is is RB cord-300061-l2pfl776 107 3 , , , cord-300061-l2pfl776 107 4 the the DT cord-300061-l2pfl776 107 5 " " `` cord-300061-l2pfl776 107 6 = = SYM cord-300061-l2pfl776 107 7 " " '' cord-300061-l2pfl776 107 8 signs sign NNS cord-300061-l2pfl776 107 9 in in IN cord-300061-l2pfl776 107 10 their -PRON- PRP$ cord-300061-l2pfl776 107 11 eq eq NN cord-300061-l2pfl776 107 12 . . . cord-300061-l2pfl776 107 13 A1 A1 NNP cord-300061-l2pfl776 107 14 and and CC cord-300061-l2pfl776 107 15 A2 A2 NNP cord-300061-l2pfl776 107 16 , , , cord-300061-l2pfl776 107 17 the the DT cord-300061-l2pfl776 107 18 basis basis NN cord-300061-l2pfl776 107 19 of of IN cord-300061-l2pfl776 107 20 the the DT cord-300061-l2pfl776 107 21 demonstration demonstration NN cord-300061-l2pfl776 107 22 , , , cord-300061-l2pfl776 107 23 are be VBP cord-300061-l2pfl776 107 24 invalid invalid JJ cord-300061-l2pfl776 107 25 . . . cord-300061-l2pfl776 108 1 S S NNP cord-300061-l2pfl776 108 2 and and CC cord-300061-l2pfl776 108 3 H H NNP cord-300061-l2pfl776 108 4 , , , cord-300061-l2pfl776 108 5 both both DT cord-300061-l2pfl776 108 6 being be VBG cord-300061-l2pfl776 108 7 functions function NNS cord-300061-l2pfl776 108 8 of of IN cord-300061-l2pfl776 108 9 all all PDT cord-300061-l2pfl776 108 10 the the DT cord-300061-l2pfl776 108 11 4 4 CD cord-300061-l2pfl776 108 12 base base NN cord-300061-l2pfl776 108 13 frequencies frequency NNS cord-300061-l2pfl776 108 14 , , , cord-300061-l2pfl776 108 15 should should MD cord-300061-l2pfl776 108 16 not not RB cord-300061-l2pfl776 108 17 be be VB cord-300061-l2pfl776 108 18 reduced reduce VBN cord-300061-l2pfl776 108 19 into into IN cord-300061-l2pfl776 108 20 functions function NNS cord-300061-l2pfl776 108 21 of of IN cord-300061-l2pfl776 108 22 one one CD cord-300061-l2pfl776 108 23 single single JJ cord-300061-l2pfl776 108 24 variable variable NN cord-300061-l2pfl776 108 25 , , , cord-300061-l2pfl776 108 26 the the DT cord-300061-l2pfl776 108 27 composition composition NN cord-300061-l2pfl776 108 28 of of IN cord-300061-l2pfl776 108 29 the the DT cord-300061-l2pfl776 108 30 nucleotide nucleotide JJ cord-300061-l2pfl776 108 31 A A NNP cord-300061-l2pfl776 108 32 only only JJ cord-300061-l2pfl776 108 33 ( ( -LRB- cord-300061-l2pfl776 108 34 eq eq NN cord-300061-l2pfl776 108 35 . . . cord-300061-l2pfl776 108 36 A3 A3 NNP cord-300061-l2pfl776 108 37 and and CC cord-300061-l2pfl776 108 38 A5 A5 NNP cord-300061-l2pfl776 108 39 , , , cord-300061-l2pfl776 108 40 [ [ -LRB- cord-300061-l2pfl776 108 41 5 5 CD cord-300061-l2pfl776 108 42 ] ] -RRB- cord-300061-l2pfl776 108 43 ) ) -RRB- cord-300061-l2pfl776 108 44 . . . cord-300061-l2pfl776 109 1 For for IN cord-300061-l2pfl776 109 2 instance instance NN cord-300061-l2pfl776 109 3 , , , cord-300061-l2pfl776 109 4 for for IN cord-300061-l2pfl776 109 5 the the DT cord-300061-l2pfl776 109 6 human human JJ cord-300061-l2pfl776 109 7 Sirtuin-3 Sirtuin-3 NNP cord-300061-l2pfl776 109 8 gene gene NN cord-300061-l2pfl776 109 9 ( ( -LRB- cord-300061-l2pfl776 109 10 AF083108 af083108 NN cord-300061-l2pfl776 109 11 ) ) -RRB- cord-300061-l2pfl776 109 12 , , , cord-300061-l2pfl776 109 13 the the DT cord-300061-l2pfl776 109 14 S S NNP cord-300061-l2pfl776 109 15 value value NN cord-300061-l2pfl776 109 16 is be VBZ cord-300061-l2pfl776 109 17 0.265 0.265 CD cord-300061-l2pfl776 110 1 ( ( -LRB- cord-300061-l2pfl776 110 2 a a DT cord-300061-l2pfl776 110 3 = = SYM cord-300061-l2pfl776 110 4 0.174 0.174 CD cord-300061-l2pfl776 110 5 , , , cord-300061-l2pfl776 110 6 c c NN cord-300061-l2pfl776 110 7 = = SYM cord-300061-l2pfl776 110 8 0.279 0.279 CD cord-300061-l2pfl776 110 9 , , , cord-300061-l2pfl776 110 10 g g NN cord-300061-l2pfl776 110 11 = = SYM cord-300061-l2pfl776 110 12 0.333 0.333 NN cord-300061-l2pfl776 110 13 and and CC cord-300061-l2pfl776 110 14 t t NN cord-300061-l2pfl776 110 15 = = SYM cord-300061-l2pfl776 110 16 0.214 0.214 CD cord-300061-l2pfl776 110 17 ) ) -RRB- cord-300061-l2pfl776 110 18 . . . cord-300061-l2pfl776 111 1 However however RB cord-300061-l2pfl776 111 2 , , , cord-300061-l2pfl776 111 3 according accord VBG cord-300061-l2pfl776 111 4 to to IN cord-300061-l2pfl776 111 5 their -PRON- PRP$ cord-300061-l2pfl776 111 6 function function NN cord-300061-l2pfl776 111 7 ( ( -LRB- cord-300061-l2pfl776 111 8 eq eq NN cord-300061-l2pfl776 111 9 . . . cord-300061-l2pfl776 111 10 A3 A3 NNP cord-300061-l2pfl776 111 11 ) ) -RRB- cord-300061-l2pfl776 111 12 in in IN cord-300061-l2pfl776 111 13 [ [ -LRB- cord-300061-l2pfl776 111 14 5 5 CD cord-300061-l2pfl776 111 15 ] ] -RRB- cord-300061-l2pfl776 111 16 , , , cord-300061-l2pfl776 111 17 the the DT cord-300061-l2pfl776 111 18 S S NNP cord-300061-l2pfl776 111 19 value value NN cord-300061-l2pfl776 111 20 becomes become VBZ cord-300061-l2pfl776 111 21 0.273 0.273 CD cord-300061-l2pfl776 111 22 . . . cord-300061-l2pfl776 112 1 Apparently apparently RB cord-300061-l2pfl776 112 2 0.265 0.265 CD cord-300061-l2pfl776 112 3 ≠ ≠ NNP cord-300061-l2pfl776 112 4 0.273 0.273 CD cord-300061-l2pfl776 112 5 . . . cord-300061-l2pfl776 113 1 In in IN cord-300061-l2pfl776 113 2 other other JJ cord-300061-l2pfl776 113 3 words word NNS cord-300061-l2pfl776 113 4 , , , cord-300061-l2pfl776 113 5 S S NNP cord-300061-l2pfl776 113 6 and and CC cord-300061-l2pfl776 113 7 H H NNP cord-300061-l2pfl776 113 8 can can MD cord-300061-l2pfl776 113 9 not not RB cord-300061-l2pfl776 113 10 be be VB cord-300061-l2pfl776 113 11 determined determine VBN cord-300061-l2pfl776 113 12 by by IN cord-300061-l2pfl776 113 13 the the DT cord-300061-l2pfl776 113 14 composition composition NN cord-300061-l2pfl776 113 15 of of IN cord-300061-l2pfl776 113 16 one one CD cord-300061-l2pfl776 113 17 single single JJ cord-300061-l2pfl776 113 18 nucleotide nucleotide NN cord-300061-l2pfl776 113 19 . . . cord-300061-l2pfl776 114 1 Therefore therefore RB cord-300061-l2pfl776 114 2 , , , cord-300061-l2pfl776 114 3 their -PRON- PRP$ cord-300061-l2pfl776 114 4 demonstration demonstration NN cord-300061-l2pfl776 114 5 is be VBZ cord-300061-l2pfl776 114 6 invalid invalid JJ cord-300061-l2pfl776 114 7 . . . cord-300061-l2pfl776 115 1 For for IN cord-300061-l2pfl776 115 2 whole whole JJ cord-300061-l2pfl776 115 3 genome genome NN cord-300061-l2pfl776 115 4 sequences sequence NNS cord-300061-l2pfl776 115 5 , , , cord-300061-l2pfl776 115 6 their -PRON- PRP$ cord-300061-l2pfl776 115 7 demonstration demonstration NN cord-300061-l2pfl776 115 8 is be VBZ cord-300061-l2pfl776 115 9 still still RB cord-300061-l2pfl776 115 10 incorrect incorrect JJ cord-300061-l2pfl776 115 11 . . . cord-300061-l2pfl776 116 1 It -PRON- PRP cord-300061-l2pfl776 116 2 is be VBZ cord-300061-l2pfl776 116 3 well well RB cord-300061-l2pfl776 116 4 known know VBN cord-300061-l2pfl776 116 5 that that IN cord-300061-l2pfl776 116 6 Chargaff Chargaff NNP cord-300061-l2pfl776 116 7 's 's POS cord-300061-l2pfl776 116 8 second second JJ cord-300061-l2pfl776 116 9 parity parity NN cord-300061-l2pfl776 116 10 rule rule NN cord-300061-l2pfl776 116 11 ( ( -LRB- cord-300061-l2pfl776 116 12 PR2 PR2 NNP cord-300061-l2pfl776 116 13 ) ) -RRB- cord-300061-l2pfl776 116 14 [ [ -LRB- cord-300061-l2pfl776 116 15 7 7 CD cord-300061-l2pfl776 116 16 ] ] -RRB- cord-300061-l2pfl776 116 17 holds hold VBZ cord-300061-l2pfl776 116 18 for for IN cord-300061-l2pfl776 116 19 most most JJS cord-300061-l2pfl776 116 20 genomes genome NNS cord-300061-l2pfl776 116 21 ( ( -LRB- cord-300061-l2pfl776 116 22 note note NN cord-300061-l2pfl776 116 23 that that IN cord-300061-l2pfl776 116 24 Figure figure NN cord-300061-l2pfl776 116 25 1 1 CD cord-300061-l2pfl776 116 26 The the DT cord-300061-l2pfl776 116 27 distribution distribution NN cord-300061-l2pfl776 116 28 of of IN cord-300061-l2pfl776 116 29 the the DT cord-300061-l2pfl776 116 30 mapping mapping NN cord-300061-l2pfl776 116 31 points point NNS cord-300061-l2pfl776 116 32 for for IN cord-300061-l2pfl776 116 33 the the DT cord-300061-l2pfl776 116 34 235 235 CD cord-300061-l2pfl776 116 35 bacterial bacterial JJ cord-300061-l2pfl776 116 36 genomes genome NNS cord-300061-l2pfl776 116 37 used use VBN cord-300061-l2pfl776 116 38 in in IN cord-300061-l2pfl776 116 39 [ [ -LRB- cord-300061-l2pfl776 116 40 5 5 CD cord-300061-l2pfl776 116 41 ] ] -RRB- cord-300061-l2pfl776 116 42 . . . cord-300061-l2pfl776 117 1 A a LS cord-300061-l2pfl776 117 2 ) ) -RRB- cord-300061-l2pfl776 118 1 The the DT cord-300061-l2pfl776 118 2 distribution distribution NN cord-300061-l2pfl776 118 3 of of IN cord-300061-l2pfl776 118 4 the the DT cord-300061-l2pfl776 118 5 mapping mapping NN cord-300061-l2pfl776 118 6 points point NNS cord-300061-l2pfl776 118 7 in in IN cord-300061-l2pfl776 118 8 the the DT cord-300061-l2pfl776 118 9 reduced reduce VBN cord-300061-l2pfl776 118 10 coordinate coordinate NN cord-300061-l2pfl776 118 11 system system NN cord-300061-l2pfl776 118 12 ( ( -LRB- cord-300061-l2pfl776 118 13 x x SYM cord-300061-l2pfl776 118 14 , , , cord-300061-l2pfl776 118 15 y y NNP cord-300061-l2pfl776 118 16 , , , cord-300061-l2pfl776 118 17 z z NNP cord-300061-l2pfl776 118 18 ) ) -RRB- cord-300061-l2pfl776 118 19 according accord VBG cord-300061-l2pfl776 118 20 to to IN cord-300061-l2pfl776 118 21 equation equation NN cord-300061-l2pfl776 118 22 ( ( -LRB- cord-300061-l2pfl776 118 23 3 3 CD cord-300061-l2pfl776 118 24 ) ) -RRB- cord-300061-l2pfl776 118 25 . . . cord-300061-l2pfl776 119 1 The the DT cord-300061-l2pfl776 119 2 square square NN cord-300061-l2pfl776 119 3 ( ( -LRB- cord-300061-l2pfl776 119 4 the the DT cord-300061-l2pfl776 119 5 side side NN cord-300061-l2pfl776 119 6 length length NN cord-300061-l2pfl776 119 7 = = SYM cord-300061-l2pfl776 119 8 2 2 CD cord-300061-l2pfl776 119 9 ) ) -RRB- cord-300061-l2pfl776 119 10 corresponds correspond VBZ cord-300061-l2pfl776 119 11 to to IN cord-300061-l2pfl776 119 12 the the DT cord-300061-l2pfl776 119 13 projection projection NN cord-300061-l2pfl776 119 14 of of IN cord-300061-l2pfl776 119 15 the the DT cord-300061-l2pfl776 119 16 regular regular JJ cord-300061-l2pfl776 119 17 tetrahedron tetrahedron NN cord-300061-l2pfl776 119 18 onto onto IN cord-300061-l2pfl776 119 19 the the DT cord-300061-l2pfl776 119 20 x x NN cord-300061-l2pfl776 119 21 - - NN cord-300061-l2pfl776 119 22 z z NNP cord-300061-l2pfl776 119 23 coordinate coordinate JJ cord-300061-l2pfl776 119 24 plane plane NN cord-300061-l2pfl776 119 25 . . . cord-300061-l2pfl776 120 1 The the DT cord-300061-l2pfl776 120 2 bold bold JJ cord-300061-l2pfl776 120 3 and and CC cord-300061-l2pfl776 120 4 dotted dotted JJ cord-300061-l2pfl776 120 5 circles circle NNS cord-300061-l2pfl776 120 6 correspond correspond VBP cord-300061-l2pfl776 120 7 to to IN cord-300061-l2pfl776 120 8 projections projection NNS cord-300061-l2pfl776 120 9 of of IN cord-300061-l2pfl776 120 10 inscribe inscribe NN cord-300061-l2pfl776 120 11 spheres sphere NNS cord-300061-l2pfl776 120 12 with with IN cord-300061-l2pfl776 120 13 the the DT cord-300061-l2pfl776 120 14 correct correct JJ cord-300061-l2pfl776 120 15 radius radius NN cord-300061-l2pfl776 120 16 length length NN cord-300061-l2pfl776 120 17 1 1 CD cord-300061-l2pfl776 120 18 3 3 CD cord-300061-l2pfl776 120 19 / / SYM cord-300061-l2pfl776 120 20 and and CC cord-300061-l2pfl776 120 21 wrongly wrongly RB cord-300061-l2pfl776 120 22 calculated calculate VBN cord-300061-l2pfl776 120 23 value value NN cord-300061-l2pfl776 120 24 1/4 1/4 CD cord-300061-l2pfl776 120 25 , , , cord-300061-l2pfl776 120 26 respectively respectively RB cord-300061-l2pfl776 120 27 . . . cord-300061-l2pfl776 121 1 Based base VBN cord-300061-l2pfl776 121 2 on on IN cord-300061-l2pfl776 121 3 the the DT cord-300061-l2pfl776 121 4 correct correct JJ cord-300061-l2pfl776 121 5 radius radius NN cord-300061-l2pfl776 121 6 , , , cord-300061-l2pfl776 121 7 in in IN cord-300061-l2pfl776 121 8 contrast contrast NN cord-300061-l2pfl776 121 9 to to IN cord-300061-l2pfl776 121 10 their -PRON- PRP$ cord-300061-l2pfl776 121 11 conclusion conclusion NN cord-300061-l2pfl776 121 12 that that IN cord-300061-l2pfl776 121 13 45 45 CD cord-300061-l2pfl776 121 14 % % NN cord-300061-l2pfl776 121 15 of of IN cord-300061-l2pfl776 121 16 genomes genome NNS cord-300061-l2pfl776 121 17 have have VBP cord-300061-l2pfl776 121 18 mapping mapping NN cord-300061-l2pfl776 121 19 points point NNS cord-300061-l2pfl776 121 20 outside outside IN cord-300061-l2pfl776 121 21 the the DT cord-300061-l2pfl776 121 22 inscribed inscribe VBN cord-300061-l2pfl776 121 23 sphere sphere NN cord-300061-l2pfl776 121 24 , , , cord-300061-l2pfl776 121 25 none none NN cord-300061-l2pfl776 121 26 has have VBZ cord-300061-l2pfl776 121 27 the the DT cord-300061-l2pfl776 121 28 mapping mapping NN cord-300061-l2pfl776 121 29 point point NN cord-300061-l2pfl776 121 30 outside outside IN cord-300061-l2pfl776 121 31 the the DT cord-300061-l2pfl776 121 32 inscribed inscribe VBN cord-300061-l2pfl776 121 33 sphere sphere NN cord-300061-l2pfl776 121 34 and and CC cord-300061-l2pfl776 121 35 none none NN cord-300061-l2pfl776 121 36 has have VBZ cord-300061-l2pfl776 121 37 an an DT cord-300061-l2pfl776 121 38 S S NNP cord-300061-l2pfl776 121 39 value value NN cord-300061-l2pfl776 121 40 larger large JJR cord-300061-l2pfl776 121 41 than than IN cord-300061-l2pfl776 121 42 1/3 1/3 CD cord-300061-l2pfl776 121 43 . . . cord-300061-l2pfl776 122 1 B b NN cord-300061-l2pfl776 122 2 ) ) -RRB- cord-300061-l2pfl776 123 1 The the DT cord-300061-l2pfl776 123 2 distribution distribution NN cord-300061-l2pfl776 123 3 of of IN cord-300061-l2pfl776 123 4 the the DT cord-300061-l2pfl776 123 5 mapping mapping NN cord-300061-l2pfl776 123 6 points point NNS cord-300061-l2pfl776 123 7 in in IN cord-300061-l2pfl776 123 8 the the DT cord-300061-l2pfl776 123 9 original original JJ cord-300061-l2pfl776 123 10 coordinate coordinate JJ cord-300061-l2pfl776 123 11 system system NN cord-300061-l2pfl776 123 12 ( ( -LRB- cord-300061-l2pfl776 123 13 X X NNS cord-300061-l2pfl776 123 14 , , , cord-300061-l2pfl776 123 15 Y Y NNP cord-300061-l2pfl776 123 16 , , , cord-300061-l2pfl776 123 17 Z Z NNP cord-300061-l2pfl776 123 18 ) ) -RRB- cord-300061-l2pfl776 123 19 according accord VBG cord-300061-l2pfl776 123 20 to to IN cord-300061-l2pfl776 123 21 equation equation NN cord-300061-l2pfl776 123 22 ( ( -LRB- cord-300061-l2pfl776 123 23 1 1 CD cord-300061-l2pfl776 123 24 ) ) -RRB- cord-300061-l2pfl776 123 25 . . . cord-300061-l2pfl776 124 1 The the DT cord-300061-l2pfl776 124 2 square square NN cord-300061-l2pfl776 124 3 ( ( -LRB- cord-300061-l2pfl776 124 4 the the DT cord-300061-l2pfl776 124 5 side side NN cord-300061-l2pfl776 124 6 length length NN cord-300061-l2pfl776 124 7 = = SYM cord-300061-l2pfl776 124 8 3 3 CD cord-300061-l2pfl776 124 9 2 2 CD cord-300061-l2pfl776 124 10 / / SYM cord-300061-l2pfl776 124 11 ) ) -RRB- cord-300061-l2pfl776 124 12 corresponds correspond VBZ cord-300061-l2pfl776 124 13 to to IN cord-300061-l2pfl776 124 14 the the DT cord-300061-l2pfl776 124 15 projection projection NN cord-300061-l2pfl776 124 16 of of IN cord-300061-l2pfl776 124 17 the the DT cord-300061-l2pfl776 124 18 regular regular JJ cord-300061-l2pfl776 124 19 tetrahedron tetrahedron NN cord-300061-l2pfl776 124 20 onto onto IN cord-300061-l2pfl776 124 21 the the DT cord-300061-l2pfl776 124 22 X x NN cord-300061-l2pfl776 124 23 - - NN cord-300061-l2pfl776 124 24 Z z JJ cord-300061-l2pfl776 124 25 coordinate coordinate JJ cord-300061-l2pfl776 124 26 plane plane NN cord-300061-l2pfl776 124 27 . . . cord-300061-l2pfl776 125 1 Note note VB cord-300061-l2pfl776 125 2 that that IN cord-300061-l2pfl776 125 3 all all DT cord-300061-l2pfl776 125 4 mapping mapping NN cord-300061-l2pfl776 125 5 points point NNS cord-300061-l2pfl776 125 6 are be VBP cord-300061-l2pfl776 125 7 within within IN cord-300061-l2pfl776 125 8 the the DT cord-300061-l2pfl776 125 9 inscribed inscribe VBN cord-300061-l2pfl776 125 10 sphere sphere NN cord-300061-l2pfl776 125 11 , , , cord-300061-l2pfl776 125 12 too too RB cord-300061-l2pfl776 125 13 , , , cord-300061-l2pfl776 125 14 whose whose WP$ cord-300061-l2pfl776 125 15 radius radius NN cord-300061-l2pfl776 125 16 length length NN cord-300061-l2pfl776 125 17 is be VBZ cord-300061-l2pfl776 125 18 1/4 1/4 CD cord-300061-l2pfl776 125 19 . . . cord-300061-l2pfl776 126 1 The the DT cord-300061-l2pfl776 126 2 mistake mistake NN cord-300061-l2pfl776 126 3 of of IN cord-300061-l2pfl776 126 4 Elhaik Elhaik NNP cord-300061-l2pfl776 126 5 et et NNP cord-300061-l2pfl776 126 6 al al NNP cord-300061-l2pfl776 126 7 . . NNP cord-300061-l2pfl776 126 8 is be VBZ cord-300061-l2pfl776 126 9 the the DT cord-300061-l2pfl776 126 10 confusion confusion NN cord-300061-l2pfl776 126 11 of of IN cord-300061-l2pfl776 126 12 the the DT cord-300061-l2pfl776 126 13 original original JJ cord-300061-l2pfl776 126 14 and and CC cord-300061-l2pfl776 126 15 reduced reduced JJ cord-300061-l2pfl776 126 16 coordinate coordinate JJ cord-300061-l2pfl776 126 17 systems system NNS cord-300061-l2pfl776 126 18 , , , cord-300061-l2pfl776 126 19 and and CC cord-300061-l2pfl776 126 20 consequently consequently RB cord-300061-l2pfl776 126 21 , , , cord-300061-l2pfl776 126 22 the the DT cord-300061-l2pfl776 126 23 neglect neglect NN cord-300061-l2pfl776 126 24 of of IN cord-300061-l2pfl776 126 25 the the DT cord-300061-l2pfl776 126 26 coordinate coordinate JJ cord-300061-l2pfl776 126 27 transform transform NN cord-300061-l2pfl776 126 28 parameter parameter NN cord-300061-l2pfl776 126 29 4 4 CD cord-300061-l2pfl776 126 30 3 3 CD cord-300061-l2pfl776 126 31 / / SYM cord-300061-l2pfl776 126 32 . . . cord-300061-l2pfl776 127 1 Refer refer VB cord-300061-l2pfl776 127 2 to to IN cord-300061-l2pfl776 127 3 text text NN cord-300061-l2pfl776 127 4 for for IN cord-300061-l2pfl776 127 5 details detail NNS cord-300061-l2pfl776 127 6 . . . cord-300061-l2pfl776 128 1 Zhang Zhang NNP cord-300061-l2pfl776 128 2 Biology Biology NNP cord-300061-l2pfl776 128 3 Direct Direct NNP cord-300061-l2pfl776 128 4 2011 2011 CD cord-300061-l2pfl776 128 5 , , , cord-300061-l2pfl776 129 1 6:10 6:10 CD cord-300061-l2pfl776 129 2 http://www.biology-direct.com/content/6/1/10 http://www.biology-direct.com/content/6/1/10 NN cord-300061-l2pfl776 129 3 not not RB cord-300061-l2pfl776 129 4 all all DT cord-300061-l2pfl776 129 5 genomes genome NNS cord-300061-l2pfl776 129 6 obey obey VBP cord-300061-l2pfl776 129 7 PR2 PR2 NNP cord-300061-l2pfl776 129 8 [ [ -LRB- cord-300061-l2pfl776 129 9 8 8 CD cord-300061-l2pfl776 129 10 ] ] -RRB- cord-300061-l2pfl776 129 11 ) ) -RRB- cord-300061-l2pfl776 129 12 . . . cord-300061-l2pfl776 130 1 It -PRON- PRP cord-300061-l2pfl776 130 2 is be VBZ cord-300061-l2pfl776 130 3 instructive instructive JJ cord-300061-l2pfl776 130 4 to to TO cord-300061-l2pfl776 130 5 know know VB cord-300061-l2pfl776 130 6 that that IN cord-300061-l2pfl776 130 7 according accord VBG cord-300061-l2pfl776 130 8 to to IN cord-300061-l2pfl776 130 9 PR2 PR2 NNP cord-300061-l2pfl776 130 10 in in IN cord-300061-l2pfl776 130 11 single single RB cord-300061-l2pfl776 130 12 - - HYPH cord-300061-l2pfl776 130 13 stranded strand VBN cord-300061-l2pfl776 130 14 DNA dna NN cord-300061-l2pfl776 130 15 , , , cord-300061-l2pfl776 130 16 a a NN cord-300061-l2pfl776 130 17 and and CC cord-300061-l2pfl776 130 18 t t NN cord-300061-l2pfl776 130 19 ( ( -LRB- cord-300061-l2pfl776 130 20 or or CC cord-300061-l2pfl776 130 21 c c NN cord-300061-l2pfl776 130 22 and and CC cord-300061-l2pfl776 130 23 g g NNP cord-300061-l2pfl776 130 24 ) ) -RRB- cord-300061-l2pfl776 130 25 are be VBP cord-300061-l2pfl776 130 26 equal equal JJ cord-300061-l2pfl776 130 27 approximately approximately RB cord-300061-l2pfl776 130 28 , , , cord-300061-l2pfl776 130 29 but but CC cord-300061-l2pfl776 130 30 it -PRON- PRP cord-300061-l2pfl776 130 31 can can MD cord-300061-l2pfl776 130 32 never never RB cord-300061-l2pfl776 130 33 be be VB cord-300061-l2pfl776 130 34 assumed assume VBN cord-300061-l2pfl776 130 35 that that IN cord-300061-l2pfl776 130 36 these these DT cord-300061-l2pfl776 130 37 base base NN cord-300061-l2pfl776 130 38 compositions composition NNS cord-300061-l2pfl776 130 39 are be VBP cord-300061-l2pfl776 130 40 exactly exactly RB cord-300061-l2pfl776 130 41 the the DT cord-300061-l2pfl776 130 42 same same JJ cord-300061-l2pfl776 130 43 . . . cord-300061-l2pfl776 131 1 In in IN cord-300061-l2pfl776 131 2 fact fact NN cord-300061-l2pfl776 131 3 , , , cord-300061-l2pfl776 131 4 deviations deviation NNS cord-300061-l2pfl776 131 5 of of IN cord-300061-l2pfl776 131 6 PR2 PR2 NNP cord-300061-l2pfl776 131 7 , , , cord-300061-l2pfl776 131 8 which which WDT cord-300061-l2pfl776 131 9 result result VBP cord-300061-l2pfl776 131 10 from from IN cord-300061-l2pfl776 131 11 both both DT cord-300061-l2pfl776 131 12 mutation mutation NN cord-300061-l2pfl776 131 13 and and CC cord-300061-l2pfl776 131 14 selection selection NN cord-300061-l2pfl776 131 15 pressures pressure NNS cord-300061-l2pfl776 131 16 , , , cord-300061-l2pfl776 131 17 reflecting reflect VBG cord-300061-l2pfl776 131 18 biases bias NNS cord-300061-l2pfl776 131 19 in in IN cord-300061-l2pfl776 131 20 , , , cord-300061-l2pfl776 131 21 for for IN cord-300061-l2pfl776 131 22 instance instance NN cord-300061-l2pfl776 131 23 , , , cord-300061-l2pfl776 131 24 DNA dna NN cord-300061-l2pfl776 131 25 replication replication NN cord-300061-l2pfl776 131 26 , , , cord-300061-l2pfl776 131 27 transcription transcription NN cord-300061-l2pfl776 131 28 and and CC cord-300061-l2pfl776 131 29 repair repair NN cord-300061-l2pfl776 131 30 , , , cord-300061-l2pfl776 131 31 have have VBP cord-300061-l2pfl776 131 32 been be VBN cord-300061-l2pfl776 131 33 an an DT cord-300061-l2pfl776 131 34 important important JJ cord-300061-l2pfl776 131 35 subject subject NN cord-300061-l2pfl776 131 36 of of IN cord-300061-l2pfl776 131 37 study study NN cord-300061-l2pfl776 131 38 in in IN cord-300061-l2pfl776 131 39 the the DT cord-300061-l2pfl776 131 40 past past JJ cord-300061-l2pfl776 131 41 decades decade NNS cord-300061-l2pfl776 131 42 [ [ -LRB- cord-300061-l2pfl776 131 43 9 9 CD cord-300061-l2pfl776 131 44 ] ] -RRB- cord-300061-l2pfl776 131 45 . . . cord-300061-l2pfl776 132 1 Therefore therefore RB cord-300061-l2pfl776 132 2 , , , cord-300061-l2pfl776 132 3 the the DT cord-300061-l2pfl776 132 4 " " `` cord-300061-l2pfl776 132 5 = = SYM cord-300061-l2pfl776 132 6 " " '' cord-300061-l2pfl776 132 7 signs sign NNS cord-300061-l2pfl776 132 8 in in IN cord-300061-l2pfl776 132 9 their -PRON- PRP$ cord-300061-l2pfl776 132 10 equations equation NNS cord-300061-l2pfl776 132 11 A1 A1 NNP cord-300061-l2pfl776 132 12 and and CC cord-300061-l2pfl776 132 13 A2 A2 NNP cord-300061-l2pfl776 132 14 are be VBP cord-300061-l2pfl776 132 15 still still RB cord-300061-l2pfl776 132 16 invalid invalid JJ cord-300061-l2pfl776 132 17 . . . cord-300061-l2pfl776 133 1 For for IN cord-300061-l2pfl776 133 2 instance instance NN cord-300061-l2pfl776 133 3 , , , cord-300061-l2pfl776 133 4 for for IN cord-300061-l2pfl776 133 5 the the DT cord-300061-l2pfl776 133 6 genome genome NN cord-300061-l2pfl776 133 7 of of IN cord-300061-l2pfl776 133 8 Elhaik Elhaik NNP cord-300061-l2pfl776 133 9 et et NNP cord-300061-l2pfl776 133 10 al al NNP cord-300061-l2pfl776 133 11 . . . cord-300061-l2pfl776 133 12 wrote write VBD cord-300061-l2pfl776 133 13 " " `` cord-300061-l2pfl776 133 14 We -PRON- PRP cord-300061-l2pfl776 133 15 note note VBP cord-300061-l2pfl776 133 16 that that IN cord-300061-l2pfl776 133 17 the the DT cord-300061-l2pfl776 133 18 relation relation NN cord-300061-l2pfl776 133 19 between between IN cord-300061-l2pfl776 133 20 S S NNP cord-300061-l2pfl776 133 21 and and CC cord-300061-l2pfl776 133 22 H H NNP cord-300061-l2pfl776 133 23 [ [ -LRB- cord-300061-l2pfl776 133 24 ... ... NFP cord-300061-l2pfl776 133 25 ] ] -RRB- cord-300061-l2pfl776 133 26 may may MD cord-300061-l2pfl776 133 27 not not RB cord-300061-l2pfl776 133 28 hold hold VB cord-300061-l2pfl776 133 29 for for IN cord-300061-l2pfl776 133 30 DNA dna NN cord-300061-l2pfl776 133 31 sequences sequence NNS cord-300061-l2pfl776 133 32 that that WDT cord-300061-l2pfl776 133 33 violate violate VBP cord-300061-l2pfl776 133 34 the the DT cord-300061-l2pfl776 133 35 second second JJ cord-300061-l2pfl776 133 36 parity parity NN cord-300061-l2pfl776 133 37 rule rule NN cord-300061-l2pfl776 133 38 , , , cord-300061-l2pfl776 133 39 such such JJ cord-300061-l2pfl776 133 40 as as IN cord-300061-l2pfl776 133 41 organellar organellar NNP cord-300061-l2pfl776 133 42 DNA dna NN cord-300061-l2pfl776 133 43 and and CC cord-300061-l2pfl776 133 44 single single JJ cord-300061-l2pfl776 133 45 stranded strand VBN cord-300061-l2pfl776 133 46 DNA dna NN cord-300061-l2pfl776 133 47 sequences sequence NNS cord-300061-l2pfl776 133 48 . . . cord-300061-l2pfl776 134 1 However however RB cord-300061-l2pfl776 134 2 , , , cord-300061-l2pfl776 134 3 even even RB cord-300061-l2pfl776 134 4 these these DT cord-300061-l2pfl776 134 5 genomes genome NNS cord-300061-l2pfl776 134 6 obey obey VBP cord-300061-l2pfl776 134 7 a a DT cord-300061-l2pfl776 134 8 less less RBR cord-300061-l2pfl776 134 9 stringent stringent JJ cord-300061-l2pfl776 134 10 rule rule NN cord-300061-l2pfl776 134 11 : : : cord-300061-l2pfl776 134 12 that that IN cord-300061-l2pfl776 134 13 the the DT cord-300061-l2pfl776 134 14 number number NN cord-300061-l2pfl776 134 15 of of IN cord-300061-l2pfl776 134 16 a a DT cord-300061-l2pfl776 134 17 + + CC cord-300061-l2pfl776 134 18 g g NN cord-300061-l2pfl776 134 19 's 's POS cord-300061-l2pfl776 134 20 approximately approximately RB cord-300061-l2pfl776 134 21 equals equal VBZ cord-300061-l2pfl776 134 22 the the DT cord-300061-l2pfl776 134 23 number number NN cord-300061-l2pfl776 134 24 of of IN cord-300061-l2pfl776 134 25 t t NN cord-300061-l2pfl776 135 1 + + CC cord-300061-l2pfl776 136 1 c c NNP cord-300061-l2pfl776 136 2 's 's POS cord-300061-l2pfl776 136 3 " " '' cord-300061-l2pfl776 136 4 . . . cord-300061-l2pfl776 137 1 Here here RB cord-300061-l2pfl776 137 2 , , , cord-300061-l2pfl776 137 3 two two CD cord-300061-l2pfl776 137 4 issues issue NNS cord-300061-l2pfl776 137 5 need need VBP cord-300061-l2pfl776 137 6 clarification clarification NN cord-300061-l2pfl776 137 7 . . . cord-300061-l2pfl776 138 1 First first RB cord-300061-l2pfl776 138 2 , , , cord-300061-l2pfl776 138 3 not not RB cord-300061-l2pfl776 138 4 only only RB cord-300061-l2pfl776 138 5 in in IN cord-300061-l2pfl776 138 6 organellar organellar JJ cord-300061-l2pfl776 138 7 DNA dna NN cord-300061-l2pfl776 138 8 and and CC cord-300061-l2pfl776 138 9 single single JJ cord-300061-l2pfl776 138 10 stranded strand VBN cord-300061-l2pfl776 138 11 DNA dna NN cord-300061-l2pfl776 138 12 sequences sequence NNS cord-300061-l2pfl776 138 13 , , , cord-300061-l2pfl776 138 14 in in IN cord-300061-l2pfl776 138 15 other other JJ cord-300061-l2pfl776 138 16 genomes genome NNS cord-300061-l2pfl776 138 17 , , , cord-300061-l2pfl776 138 18 also also RB cord-300061-l2pfl776 138 19 , , , cord-300061-l2pfl776 138 20 the the DT cord-300061-l2pfl776 138 21 compositions composition NNS cord-300061-l2pfl776 138 22 a a DT cord-300061-l2pfl776 138 23 + + CC cord-300061-l2pfl776 138 24 g g NN cord-300061-l2pfl776 138 25 and and CC cord-300061-l2pfl776 138 26 t t NN cord-300061-l2pfl776 138 27 + + CC cord-300061-l2pfl776 138 28 c c NN cord-300061-l2pfl776 138 29 are be VBP cord-300061-l2pfl776 138 30 only only RB cord-300061-l2pfl776 138 31 equal equal JJ cord-300061-l2pfl776 138 32 approximately approximately RB cord-300061-l2pfl776 138 33 . . . cord-300061-l2pfl776 139 1 Second second RB cord-300061-l2pfl776 139 2 , , , cord-300061-l2pfl776 139 3 for for IN cord-300061-l2pfl776 139 4 those those DT cord-300061-l2pfl776 139 5 genomes genome NNS cord-300061-l2pfl776 139 6 that that WDT cord-300061-l2pfl776 139 7 obey obey VBP cord-300061-l2pfl776 139 8 a a DT cord-300061-l2pfl776 139 9 more more RBR cord-300061-l2pfl776 139 10 " " `` cord-300061-l2pfl776 139 11 stringent stringent JJ cord-300061-l2pfl776 139 12 " " '' cord-300061-l2pfl776 139 13 PR2 pr2 NN cord-300061-l2pfl776 139 14 rule rule NN cord-300061-l2pfl776 139 15 , , , cord-300061-l2pfl776 139 16 these these DT cord-300061-l2pfl776 139 17 compositions composition NNS cord-300061-l2pfl776 139 18 are be VBP cord-300061-l2pfl776 139 19 still still RB cord-300061-l2pfl776 139 20 only only RB cord-300061-l2pfl776 139 21 equal equal JJ cord-300061-l2pfl776 139 22 approximately approximately RB cord-300061-l2pfl776 139 23 , , , cord-300061-l2pfl776 139 24 but but CC cord-300061-l2pfl776 139 25 can can MD cord-300061-l2pfl776 139 26 never never RB cord-300061-l2pfl776 139 27 be be VB cord-300061-l2pfl776 139 28 assumed assume VBN cord-300061-l2pfl776 139 29 as as IN cord-300061-l2pfl776 139 30 exactly exactly RB cord-300061-l2pfl776 139 31 the the DT cord-300061-l2pfl776 139 32 same same JJ cord-300061-l2pfl776 139 33 . . . cord-300061-l2pfl776 140 1 Deviations deviation NNS cord-300061-l2pfl776 140 2 from from IN cord-300061-l2pfl776 140 3 PR2 PR2 NNP cord-300061-l2pfl776 140 4 , , , cord-300061-l2pfl776 140 5 although although IN cord-300061-l2pfl776 140 6 small small JJ cord-300061-l2pfl776 140 7 , , , cord-300061-l2pfl776 140 8 contain contain VBP cord-300061-l2pfl776 140 9 critical critical JJ cord-300061-l2pfl776 140 10 and and CC cord-300061-l2pfl776 140 11 rich rich JJ cord-300061-l2pfl776 140 12 information information NN cord-300061-l2pfl776 140 13 , , , cord-300061-l2pfl776 140 14 and and CC cord-300061-l2pfl776 140 15 these these DT cord-300061-l2pfl776 140 16 deviations deviation NNS cord-300061-l2pfl776 140 17 differ differ VBP cord-300061-l2pfl776 140 18 among among IN cord-300061-l2pfl776 140 19 genomes genome NNS cord-300061-l2pfl776 140 20 , , , cord-300061-l2pfl776 140 21 and and CC cord-300061-l2pfl776 140 22 they -PRON- PRP cord-300061-l2pfl776 140 23 thus thus RB cord-300061-l2pfl776 140 24 should should MD cord-300061-l2pfl776 140 25 not not RB cord-300061-l2pfl776 140 26 be be VB cord-300061-l2pfl776 140 27 simply simply RB cord-300061-l2pfl776 140 28 disregarded disregard VBN cord-300061-l2pfl776 140 29 and and CC cord-300061-l2pfl776 140 30 treated treat VBN cord-300061-l2pfl776 140 31 as as IN cord-300061-l2pfl776 140 32 0 0 CD cord-300061-l2pfl776 140 33 altogether altogether RB cord-300061-l2pfl776 140 34 , , , cord-300061-l2pfl776 140 35 i.e. i.e. FW cord-300061-l2pfl776 140 36 , , , cord-300061-l2pfl776 140 37 for for IN cord-300061-l2pfl776 140 38 genomes genome NNS cord-300061-l2pfl776 140 39 , , , cord-300061-l2pfl776 140 40 S S NNP cord-300061-l2pfl776 140 41 and and CC cord-300061-l2pfl776 140 42 H H NNP cord-300061-l2pfl776 140 43 still still RB cord-300061-l2pfl776 140 44 should should MD cord-300061-l2pfl776 140 45 not not RB cord-300061-l2pfl776 140 46 be be VB cord-300061-l2pfl776 140 47 treated treat VBN cord-300061-l2pfl776 140 48 as as IN cord-300061-l2pfl776 140 49 functions function NNS cord-300061-l2pfl776 140 50 of of IN cord-300061-l2pfl776 140 51 the the DT cord-300061-l2pfl776 140 52 composition composition NN cord-300061-l2pfl776 140 53 of of IN cord-300061-l2pfl776 140 54 one one CD cord-300061-l2pfl776 140 55 single single JJ cord-300061-l2pfl776 140 56 nucleotide nucleotide NN cord-300061-l2pfl776 140 57 A a DT cord-300061-l2pfl776 140 58 only only JJ cord-300061-l2pfl776 140 59 ( ( -LRB- cord-300061-l2pfl776 140 60 eq eq NN cord-300061-l2pfl776 140 61 . . . cord-300061-l2pfl776 140 62 A3 A3 NNP cord-300061-l2pfl776 140 63 and and CC cord-300061-l2pfl776 140 64 A5 a5 NN cord-300061-l2pfl776 140 65 in in IN cord-300061-l2pfl776 140 66 [ [ -LRB- cord-300061-l2pfl776 140 67 5 5 CD cord-300061-l2pfl776 140 68 ] ] -RRB- cord-300061-l2pfl776 140 69 ) ) -RRB- cord-300061-l2pfl776 140 70 . . . cord-300061-l2pfl776 141 1 Therefore therefore RB cord-300061-l2pfl776 141 2 , , , cord-300061-l2pfl776 141 3 for for IN cord-300061-l2pfl776 141 4 genomes genome NNS cord-300061-l2pfl776 141 5 their -PRON- PRP$ cord-300061-l2pfl776 141 6 demonstration demonstration NN cord-300061-l2pfl776 141 7 is be VBZ cord-300061-l2pfl776 141 8 still still RB cord-300061-l2pfl776 141 9 invalid invalid JJ cord-300061-l2pfl776 141 10 . . . cord-300061-l2pfl776 142 1 In in IN cord-300061-l2pfl776 142 2 some some DT cord-300061-l2pfl776 142 3 cases case NNS cord-300061-l2pfl776 142 4 , , , cord-300061-l2pfl776 142 5 e.g. e.g. RB cord-300061-l2pfl776 142 6 , , , cord-300061-l2pfl776 142 7 for for IN cord-300061-l2pfl776 142 8 whole whole JJ cord-300061-l2pfl776 142 9 genomes genome NNS cord-300061-l2pfl776 142 10 , , , cord-300061-l2pfl776 142 11 S S NNP cord-300061-l2pfl776 142 12 and and CC cord-300061-l2pfl776 142 13 H H NNP cord-300061-l2pfl776 142 14 can can MD cord-300061-l2pfl776 142 15 be be VB cord-300061-l2pfl776 142 16 correlated correlate VBN cord-300061-l2pfl776 142 17 . . . cord-300061-l2pfl776 143 1 In in IN cord-300061-l2pfl776 143 2 2004 2004 CD cord-300061-l2pfl776 143 3 , , , cord-300061-l2pfl776 143 4 we -PRON- PRP cord-300061-l2pfl776 143 5 first first RB cord-300061-l2pfl776 143 6 indicated indicate VBD cord-300061-l2pfl776 143 7 that that IN cord-300061-l2pfl776 143 8 S S NNP cord-300061-l2pfl776 143 9 and and CC cord-300061-l2pfl776 143 10 H H NNP cord-300061-l2pfl776 143 11 are be VBP cord-300061-l2pfl776 143 12 negatively negatively RB cord-300061-l2pfl776 143 13 correlated correlate VBN cord-300061-l2pfl776 143 14 for for IN cord-300061-l2pfl776 143 15 genomes genome NNS cord-300061-l2pfl776 143 16 [ [ -LRB- cord-300061-l2pfl776 143 17 2 2 CD cord-300061-l2pfl776 143 18 ] ] -RRB- cord-300061-l2pfl776 143 19 , , , cord-300061-l2pfl776 143 20 hence hence RB cord-300061-l2pfl776 143 21 the the DT cord-300061-l2pfl776 143 22 name name NN cord-300061-l2pfl776 143 23 genome genome NN cord-300061-l2pfl776 143 24 order order NN cord-300061-l2pfl776 143 25 index index NN cord-300061-l2pfl776 143 26 . . . cord-300061-l2pfl776 144 1 In in IN cord-300061-l2pfl776 144 2 fact fact NN cord-300061-l2pfl776 144 3 , , , cord-300061-l2pfl776 144 4 both both CC cord-300061-l2pfl776 144 5 S S NNP cord-300061-l2pfl776 144 6 and and CC cord-300061-l2pfl776 144 7 H H NNP cord-300061-l2pfl776 144 8 are be VBP cord-300061-l2pfl776 144 9 special special JJ cord-300061-l2pfl776 144 10 forms form NNS cord-300061-l2pfl776 144 11 of of IN cord-300061-l2pfl776 144 12 the the DT cord-300061-l2pfl776 144 13 a a DT cord-300061-l2pfl776 144 14 - - HYPH cord-300061-l2pfl776 144 15 order order NN cord-300061-l2pfl776 144 16 entropy entropy NN cord-300061-l2pfl776 144 17 [ [ -LRB- cord-300061-l2pfl776 144 18 10 10 CD cord-300061-l2pfl776 144 19 ] ] -RRB- cord-300061-l2pfl776 144 20 . . . cord-300061-l2pfl776 145 1 Suppose suppose VB cord-300061-l2pfl776 145 2 that that IN cord-300061-l2pfl776 145 3 there there EX cord-300061-l2pfl776 145 4 is be VBZ cord-300061-l2pfl776 145 5 a a DT cord-300061-l2pfl776 145 6 random random JJ cord-300061-l2pfl776 145 7 variable variable NN cord-300061-l2pfl776 145 8 X x NN cord-300061-l2pfl776 145 9 ~ ~ CD cord-300061-l2pfl776 145 10 p(x p(x ADD cord-300061-l2pfl776 145 11 ) ) -RRB- cord-300061-l2pfl776 145 12 , , , cord-300061-l2pfl776 145 13 the the DT cord-300061-l2pfl776 145 14 a a DT cord-300061-l2pfl776 145 15 - - HYPH cord-300061-l2pfl776 145 16 order order NN cord-300061-l2pfl776 145 17 entropy entropy NN cord-300061-l2pfl776 145 18 is be VBZ cord-300061-l2pfl776 145 19 defined define VBN cord-300061-l2pfl776 145 20 as as IN cord-300061-l2pfl776 145 21 It -PRON- PRP cord-300061-l2pfl776 145 22 was be VBD cord-300061-l2pfl776 145 23 shown show VBN cord-300061-l2pfl776 145 24 that that IN cord-300061-l2pfl776 145 25 where where WRB cord-300061-l2pfl776 145 26 H H NNP cord-300061-l2pfl776 145 27 ( ( -LRB- cord-300061-l2pfl776 145 28 X X NNP cord-300061-l2pfl776 145 29 ) ) -RRB- cord-300061-l2pfl776 145 30 is be VBZ cord-300061-l2pfl776 145 31 the the DT cord-300061-l2pfl776 145 32 Shannon Shannon NNP cord-300061-l2pfl776 145 33 entropy entropy NN cord-300061-l2pfl776 145 34 . . . cord-300061-l2pfl776 146 1 Specially specially RB cord-300061-l2pfl776 146 2 , , , cord-300061-l2pfl776 146 3 if if IN cord-300061-l2pfl776 146 4 a a DT cord-300061-l2pfl776 146 5 = = SYM cord-300061-l2pfl776 146 6 2 2 CD cord-300061-l2pfl776 146 7 , , , cord-300061-l2pfl776 146 8 eq eq NNP cord-300061-l2pfl776 146 9 . . . cord-300061-l2pfl776 146 10 ( ( -LRB- cord-300061-l2pfl776 146 11 6 6 CD cord-300061-l2pfl776 146 12 ) ) -RRB- cord-300061-l2pfl776 146 13 reads read VBZ cord-300061-l2pfl776 146 14 where where WRB cord-300061-l2pfl776 146 15 the the DT cord-300061-l2pfl776 146 16 last last JJ cord-300061-l2pfl776 146 17 two two CD cord-300061-l2pfl776 146 18 equal equal JJ cord-300061-l2pfl776 146 19 signs sign NNS cord-300061-l2pfl776 146 20 are be VBP cord-300061-l2pfl776 146 21 valid valid JJ cord-300061-l2pfl776 146 22 only only RB cord-300061-l2pfl776 146 23 for for IN cord-300061-l2pfl776 146 24 a a DT cord-300061-l2pfl776 146 25 discrete discrete JJ cord-300061-l2pfl776 146 26 uniform uniform JJ cord-300061-l2pfl776 146 27 distribution distribution NN cord-300061-l2pfl776 146 28 of of IN cord-300061-l2pfl776 146 29 four four CD cord-300061-l2pfl776 146 30 alphabetic alphabetic JJ cord-300061-l2pfl776 146 31 symbols symbol NNS cord-300061-l2pfl776 146 32 . . . cord-300061-l2pfl776 147 1 As as IN cord-300061-l2pfl776 147 2 I -PRON- PRP cord-300061-l2pfl776 147 3 indicated indicate VBD cord-300061-l2pfl776 147 4 in in IN cord-300061-l2pfl776 147 5 [ [ -LRB- cord-300061-l2pfl776 147 6 4 4 CD cord-300061-l2pfl776 147 7 ] ] -RRB- cord-300061-l2pfl776 147 8 , , , cord-300061-l2pfl776 147 9 S S NNP cord-300061-l2pfl776 147 10 is be VBZ cord-300061-l2pfl776 147 11 a a DT cord-300061-l2pfl776 147 12 linear linear JJ cord-300061-l2pfl776 147 13 transformation transformation NN cord-300061-l2pfl776 147 14 of of IN cord-300061-l2pfl776 147 15 a a DT cord-300061-l2pfl776 147 16 special special JJ cord-300061-l2pfl776 147 17 case case NN cord-300061-l2pfl776 147 18 ( ( -LRB- cord-300061-l2pfl776 147 19 4 4 CD cord-300061-l2pfl776 147 20 alphabetic alphabetic JJ cord-300061-l2pfl776 147 21 symbols symbol NNS cord-300061-l2pfl776 147 22 ) ) -RRB- cord-300061-l2pfl776 147 23 of of IN cord-300061-l2pfl776 147 24 H H NNP cord-300061-l2pfl776 147 25 2 2 CD cord-300061-l2pfl776 147 26 ( ( -LRB- cord-300061-l2pfl776 147 27 X X NNP cord-300061-l2pfl776 147 28 ) ) -RRB- cord-300061-l2pfl776 147 29 , , . cord-300061-l2pfl776 148 1 the the DT cord-300061-l2pfl776 148 2 Gini Gini NNP cord-300061-l2pfl776 148 3 - - HYPH cord-300061-l2pfl776 148 4 Simpson Simpson NNP cord-300061-l2pfl776 148 5 index index NN cord-300061-l2pfl776 148 6 . . . cord-300061-l2pfl776 149 1 This this DT cord-300061-l2pfl776 149 2 index index NN cord-300061-l2pfl776 149 3 is be VBZ cord-300061-l2pfl776 149 4 a a DT cord-300061-l2pfl776 149 5 general general JJ cord-300061-l2pfl776 149 6 information information NN cord-300061-l2pfl776 149 7 index index NN cord-300061-l2pfl776 149 8 used use VBN cord-300061-l2pfl776 149 9 in in IN cord-300061-l2pfl776 149 10 many many JJ cord-300061-l2pfl776 149 11 areas area NNS cord-300061-l2pfl776 149 12 , , , cord-300061-l2pfl776 149 13 while while IN cord-300061-l2pfl776 149 14 S S NNP cord-300061-l2pfl776 149 15 , , , cord-300061-l2pfl776 149 16 which which WDT cord-300061-l2pfl776 149 17 is be VBZ cord-300061-l2pfl776 149 18 derived derive VBN cord-300061-l2pfl776 149 19 from from IN cord-300061-l2pfl776 149 20 a a DT cord-300061-l2pfl776 149 21 totally totally RB cord-300061-l2pfl776 149 22 independent independent JJ cord-300061-l2pfl776 149 23 way way NN cord-300061-l2pfl776 149 24 , , , cord-300061-l2pfl776 149 25 is be VBZ cord-300061-l2pfl776 149 26 a a DT cord-300061-l2pfl776 149 27 special special JJ cord-300061-l2pfl776 149 28 one one NN cord-300061-l2pfl776 149 29 for for IN cord-300061-l2pfl776 149 30 the the DT cord-300061-l2pfl776 149 31 analysis analysis NN cord-300061-l2pfl776 149 32 of of IN cord-300061-l2pfl776 149 33 DNA dna NN cord-300061-l2pfl776 149 34 sequences sequence NNS cord-300061-l2pfl776 149 35 , , , cord-300061-l2pfl776 149 36 and and CC cord-300061-l2pfl776 149 37 additionally additionally RB cord-300061-l2pfl776 149 38 , , , cord-300061-l2pfl776 149 39 S S NNP cord-300061-l2pfl776 149 40 has have VBZ cord-300061-l2pfl776 149 41 a a DT cord-300061-l2pfl776 149 42 clear clear JJ cord-300061-l2pfl776 149 43 geometrical geometrical JJ cord-300061-l2pfl776 149 44 meaning meaning NN cord-300061-l2pfl776 149 45 , , , cord-300061-l2pfl776 149 46 i.e. i.e. FW cord-300061-l2pfl776 149 47 , , , cord-300061-l2pfl776 149 48 S S NNP cord-300061-l2pfl776 149 49 is be VBZ cord-300061-l2pfl776 149 50 proportional proportional JJ cord-300061-l2pfl776 149 51 to to IN cord-300061-l2pfl776 149 52 the the DT cord-300061-l2pfl776 149 53 square square NN cord-300061-l2pfl776 149 54 of of IN cord-300061-l2pfl776 149 55 the the DT cord-300061-l2pfl776 149 56 distance distance NN cord-300061-l2pfl776 149 57 between between IN cord-300061-l2pfl776 149 58 a a DT cord-300061-l2pfl776 149 59 point point NN cord-300061-l2pfl776 149 60 and and CC cord-300061-l2pfl776 149 61 the the DT cord-300061-l2pfl776 149 62 RT RT NNP cord-300061-l2pfl776 149 63 origin origin NN cord-300061-l2pfl776 149 64 in in IN cord-300061-l2pfl776 149 65 the the DT cord-300061-l2pfl776 149 66 mapping mapping NN cord-300061-l2pfl776 149 67 system system NN cord-300061-l2pfl776 149 68 that that WDT cord-300061-l2pfl776 149 69 we -PRON- PRP cord-300061-l2pfl776 149 70 proposed propose VBD cord-300061-l2pfl776 149 71 [ [ -LRB- cord-300061-l2pfl776 149 72 1 1 CD cord-300061-l2pfl776 149 73 ] ] -RRB- cord-300061-l2pfl776 149 74 . . . cord-300061-l2pfl776 150 1 Generally generally RB cord-300061-l2pfl776 150 2 , , , cord-300061-l2pfl776 150 3 S S NNP cord-300061-l2pfl776 150 4 and and CC cord-300061-l2pfl776 150 5 H H NNP cord-300061-l2pfl776 150 6 are be VBP cord-300061-l2pfl776 150 7 neither neither RB cord-300061-l2pfl776 150 8 equivalent equivalent JJ cord-300061-l2pfl776 150 9 nor nor CC cord-300061-l2pfl776 150 10 derivable derivable JJ cord-300061-l2pfl776 150 11 from from IN cord-300061-l2pfl776 150 12 each each DT cord-300061-l2pfl776 150 13 other other JJ cord-300061-l2pfl776 150 14 . . . cord-300061-l2pfl776 151 1 For for IN cord-300061-l2pfl776 151 2 whole whole JJ cord-300061-l2pfl776 151 3 genomes genome NNS cord-300061-l2pfl776 151 4 , , , cord-300061-l2pfl776 151 5 they -PRON- PRP cord-300061-l2pfl776 151 6 can can MD cord-300061-l2pfl776 151 7 be be VB cord-300061-l2pfl776 151 8 correlated correlate VBN cord-300061-l2pfl776 151 9 . . . cord-300061-l2pfl776 152 1 The the DT cord-300061-l2pfl776 152 2 relation relation NN cord-300061-l2pfl776 152 3 between between IN cord-300061-l2pfl776 152 4 S S NNP cord-300061-l2pfl776 152 5 and and CC cord-300061-l2pfl776 152 6 H H NNP cord-300061-l2pfl776 152 7 is be VBZ cord-300061-l2pfl776 152 8 complex complex JJ cord-300061-l2pfl776 152 9 ; ; : cord-300061-l2pfl776 152 10 as as IN cord-300061-l2pfl776 152 11 shown show VBN cord-300061-l2pfl776 152 12 in in IN cord-300061-l2pfl776 152 13 [ [ -LRB- cord-300061-l2pfl776 152 14 11 11 CD cord-300061-l2pfl776 152 15 ] ] -RRB- cord-300061-l2pfl776 152 16 , , , cord-300061-l2pfl776 152 17 the the DT cord-300061-l2pfl776 152 18 relation relation NN cord-300061-l2pfl776 152 19 differs differ VBZ cord-300061-l2pfl776 152 20 in in IN cord-300061-l2pfl776 152 21 different different JJ cord-300061-l2pfl776 152 22 cases case NNS cord-300061-l2pfl776 152 23 , , , cord-300061-l2pfl776 152 24 e.g. e.g. RB cord-300061-l2pfl776 152 25 , , , cord-300061-l2pfl776 152 26 different different JJ cord-300061-l2pfl776 152 27 value value NN cord-300061-l2pfl776 152 28 ranges range NNS cord-300061-l2pfl776 152 29 . . . cord-300061-l2pfl776 153 1 In in IN cord-300061-l2pfl776 153 2 genome genome NN cord-300061-l2pfl776 153 3 segmentation segmentation NN cord-300061-l2pfl776 153 4 studies study NNS cord-300061-l2pfl776 153 5 , , , cord-300061-l2pfl776 153 6 S S NNP cord-300061-l2pfl776 153 7 outperforms outperform VBZ cord-300061-l2pfl776 153 8 H h NN cord-300061-l2pfl776 153 9 by by IN cord-300061-l2pfl776 153 10 having have VBG cord-300061-l2pfl776 153 11 a a DT cord-300061-l2pfl776 153 12 faster fast JJR cord-300061-l2pfl776 153 13 computation computation NN cord-300061-l2pfl776 153 14 time time NN cord-300061-l2pfl776 153 15 , , , cord-300061-l2pfl776 153 16 which which WDT cord-300061-l2pfl776 153 17 is be VBZ cord-300061-l2pfl776 153 18 especially especially RB cord-300061-l2pfl776 153 19 important important JJ cord-300061-l2pfl776 153 20 for for IN cord-300061-l2pfl776 153 21 handling handle VBG cord-300061-l2pfl776 153 22 large large JJ cord-300061-l2pfl776 153 23 genomes genome NNS cord-300061-l2pfl776 153 24 , , , cord-300061-l2pfl776 153 25 such such JJ cord-300061-l2pfl776 153 26 as as IN cord-300061-l2pfl776 153 27 the the DT cord-300061-l2pfl776 153 28 human human JJ cord-300061-l2pfl776 153 29 genome genome NN cord-300061-l2pfl776 153 30 [ [ -LRB- cord-300061-l2pfl776 153 31 6 6 CD cord-300061-l2pfl776 153 32 ] ] -RRB- cord-300061-l2pfl776 153 33 . . . cord-300061-l2pfl776 154 1 Does do VBZ cord-300061-l2pfl776 154 2 Z z NN cord-300061-l2pfl776 154 3 - - HYPH cord-300061-l2pfl776 154 4 curve curve NN cord-300061-l2pfl776 154 5 have have VBP cord-300061-l2pfl776 154 6 over over IN cord-300061-l2pfl776 154 7 dimensionality dimensionality NN cord-300061-l2pfl776 154 8 ? ? . cord-300061-l2pfl776 155 1 In in IN cord-300061-l2pfl776 155 2 this this DT cord-300061-l2pfl776 155 3 section section NN cord-300061-l2pfl776 155 4 , , , cord-300061-l2pfl776 155 5 Elhaik Elhaik NNP cord-300061-l2pfl776 155 6 et et NNP cord-300061-l2pfl776 155 7 al al NNP cord-300061-l2pfl776 155 8 . . . cord-300061-l2pfl776 156 1 switch switch VB cord-300061-l2pfl776 156 2 topic topic NN cord-300061-l2pfl776 156 3 from from IN cord-300061-l2pfl776 156 4 S S NNP cord-300061-l2pfl776 156 5 to to IN cord-300061-l2pfl776 156 6 Z z NN cord-300061-l2pfl776 156 7 - - HYPH cord-300061-l2pfl776 156 8 curve curve NN cord-300061-l2pfl776 156 9 , , , cord-300061-l2pfl776 156 10 claiming claim VBG cord-300061-l2pfl776 156 11 that that IN cord-300061-l2pfl776 156 12 Z z NN cord-300061-l2pfl776 156 13 - - HYPH cord-300061-l2pfl776 156 14 curve curve NN cord-300061-l2pfl776 156 15 suffers suffer VBZ cord-300061-l2pfl776 156 16 from from IN cord-300061-l2pfl776 156 17 " " `` cord-300061-l2pfl776 156 18 over over IN cord-300061-l2pfl776 156 19 dimensionality dimensionality NN cord-300061-l2pfl776 156 20 " " '' cord-300061-l2pfl776 156 21 . . . cord-300061-l2pfl776 157 1 This this DT cord-300061-l2pfl776 157 2 conclusion conclusion NN cord-300061-l2pfl776 157 3 is be VBZ cord-300061-l2pfl776 157 4 based base VBN cord-300061-l2pfl776 157 5 on on IN cord-300061-l2pfl776 157 6 the the DT cord-300061-l2pfl776 157 7 analysis analysis NN cord-300061-l2pfl776 157 8 of of IN cord-300061-l2pfl776 157 9 235 235 CD cord-300061-l2pfl776 157 10 bacterial bacterial JJ cord-300061-l2pfl776 157 11 genomes genome NNS cord-300061-l2pfl776 157 12 . . . cord-300061-l2pfl776 158 1 Using use VBG cord-300061-l2pfl776 158 2 principal principal JJ cord-300061-l2pfl776 158 3 component component NN cord-300061-l2pfl776 158 4 analysis analysis NN cord-300061-l2pfl776 158 5 ( ( -LRB- cord-300061-l2pfl776 158 6 PCA PCA NNP cord-300061-l2pfl776 158 7 ) ) -RRB- cord-300061-l2pfl776 158 8 , , , cord-300061-l2pfl776 158 9 Elhaik Elhaik NNP cord-300061-l2pfl776 158 10 et et NNP cord-300061-l2pfl776 158 11 al al NNP cord-300061-l2pfl776 158 12 . . NNP cord-300061-l2pfl776 158 13 found find VBD cord-300061-l2pfl776 158 14 that that IN cord-300061-l2pfl776 158 15 " " `` cord-300061-l2pfl776 158 16 99.91 99.91 CD cord-300061-l2pfl776 158 17 % % NN cord-300061-l2pfl776 158 18 of of IN cord-300061-l2pfl776 158 19 the the DT cord-300061-l2pfl776 158 20 variance variance NN cord-300061-l2pfl776 158 21 is be VBZ cord-300061-l2pfl776 158 22 accounted account VBN cord-300061-l2pfl776 158 23 for for IN cord-300061-l2pfl776 158 24 by by IN cord-300061-l2pfl776 158 25 the the DT cord-300061-l2pfl776 158 26 z z NNP cord-300061-l2pfl776 158 27 coordinate coordinate NN cord-300061-l2pfl776 158 28 , , , cord-300061-l2pfl776 158 29 and and CC cord-300061-l2pfl776 158 30 the the DT cord-300061-l2pfl776 158 31 x x NN cord-300061-l2pfl776 158 32 and and CC cord-300061-l2pfl776 158 33 y y NNP cord-300061-l2pfl776 158 34 coordinates coordinate VBZ cord-300061-l2pfl776 158 35 accounted account VBD cord-300061-l2pfl776 158 36 for for IN cord-300061-l2pfl776 158 37 0.053 0.053 CD cord-300061-l2pfl776 158 38 % % NN cord-300061-l2pfl776 158 39 and and CC cord-300061-l2pfl776 158 40 0.003 0.003 CD cord-300061-l2pfl776 158 41 % % NN cord-300061-l2pfl776 158 42 of of IN cord-300061-l2pfl776 158 43 the the DT cord-300061-l2pfl776 158 44 variance variance NN cord-300061-l2pfl776 158 45 , , , cord-300061-l2pfl776 158 46 respectively respectively RB cord-300061-l2pfl776 158 47 " " '' cord-300061-l2pfl776 158 48 . . . cord-300061-l2pfl776 159 1 They -PRON- PRP cord-300061-l2pfl776 159 2 conclude conclude VBP cord-300061-l2pfl776 159 3 that that IN cord-300061-l2pfl776 159 4 " " `` cord-300061-l2pfl776 159 5 the the DT cord-300061-l2pfl776 159 6 z z NNP cord-300061-l2pfl776 159 7 axis axis NN cord-300061-l2pfl776 159 8 is be VBZ cord-300061-l2pfl776 159 9 , , , cord-300061-l2pfl776 159 10 therefore therefore RB cord-300061-l2pfl776 159 11 , , , cord-300061-l2pfl776 159 12 the the DT cord-300061-l2pfl776 159 13 only only JJ cord-300061-l2pfl776 159 14 meaningful meaningful JJ cord-300061-l2pfl776 159 15 coordinate coordinate NN cord-300061-l2pfl776 159 16 for for IN cord-300061-l2pfl776 159 17 studying study VBG cord-300061-l2pfl776 159 18 nucleotide nucleotide JJ cord-300061-l2pfl776 159 19 composition composition NN cord-300061-l2pfl776 159 20 . . . cord-300061-l2pfl776 159 21 " " '' cord-300061-l2pfl776 160 1 and and CC cord-300061-l2pfl776 160 2 x x SYM cord-300061-l2pfl776 160 3 and and CC cord-300061-l2pfl776 160 4 y y NNP cord-300061-l2pfl776 160 5 contribute contribute VBP cord-300061-l2pfl776 160 6 only only RB cord-300061-l2pfl776 160 7 less less JJR cord-300061-l2pfl776 160 8 than than IN cord-300061-l2pfl776 160 9 1 1 CD cord-300061-l2pfl776 160 10 % % NN cord-300061-l2pfl776 160 11 of of IN cord-300061-l2pfl776 160 12 the the DT cord-300061-l2pfl776 160 13 variance variance NN cord-300061-l2pfl776 160 14 and and CC cord-300061-l2pfl776 160 15 therefore therefore RB cord-300061-l2pfl776 160 16 " " `` cord-300061-l2pfl776 160 17 would would MD cord-300061-l2pfl776 160 18 be be VB cord-300061-l2pfl776 160 19 of of IN cord-300061-l2pfl776 160 20 little little JJ cord-300061-l2pfl776 160 21 use use NN cord-300061-l2pfl776 160 22 " " '' cord-300061-l2pfl776 160 23 . . . cord-300061-l2pfl776 161 1 Assuming assume VBG cord-300061-l2pfl776 161 2 that that IN cord-300061-l2pfl776 161 3 the the DT cord-300061-l2pfl776 161 4 235 235 CD cord-300061-l2pfl776 161 5 bacterial bacterial JJ cord-300061-l2pfl776 161 6 genomes genome NNS cord-300061-l2pfl776 161 7 that that WDT cord-300061-l2pfl776 161 8 they -PRON- PRP cord-300061-l2pfl776 161 9 selected select VBD cord-300061-l2pfl776 161 10 were be VBD cord-300061-l2pfl776 161 11 indeed indeed RB cord-300061-l2pfl776 161 12 representatives representative NNS cord-300061-l2pfl776 161 13 of of IN cord-300061-l2pfl776 161 14 all all DT cord-300061-l2pfl776 161 15 genomes genome NNS cord-300061-l2pfl776 161 16 , , , cord-300061-l2pfl776 161 17 including include VBG cord-300061-l2pfl776 161 18 those those DT cord-300061-l2pfl776 161 19 of of IN cord-300061-l2pfl776 161 20 eukaryotes eukaryote NNS cord-300061-l2pfl776 161 21 , , , cord-300061-l2pfl776 161 22 viruses virus NNS cord-300061-l2pfl776 161 23 and and CC cord-300061-l2pfl776 161 24 archaea archaea NNS cord-300061-l2pfl776 161 25 , , , cord-300061-l2pfl776 161 26 which which WDT cord-300061-l2pfl776 161 27 is be VBZ cord-300061-l2pfl776 161 28 unlikely unlikely JJ cord-300061-l2pfl776 161 29 , , , cord-300061-l2pfl776 161 30 the the DT cord-300061-l2pfl776 161 31 process process NN cord-300061-l2pfl776 161 32 reaching reach VBG cord-300061-l2pfl776 161 33 this this DT cord-300061-l2pfl776 161 34 conclusion conclusion NN cord-300061-l2pfl776 161 35 is be VBZ cord-300061-l2pfl776 161 36 still still RB cord-300061-l2pfl776 161 37 logically logically RB cord-300061-l2pfl776 161 38 flawed flawed JJ cord-300061-l2pfl776 161 39 . . . cord-300061-l2pfl776 162 1 First first RB cord-300061-l2pfl776 162 2 , , , cord-300061-l2pfl776 162 3 they -PRON- PRP cord-300061-l2pfl776 162 4 confuse confuse VBP cord-300061-l2pfl776 162 5 numeral numeral JJ cord-300061-l2pfl776 162 6 smallness smallness NN cord-300061-l2pfl776 162 7 with with IN cord-300061-l2pfl776 162 8 biological biological JJ cord-300061-l2pfl776 162 9 insignificance insignificance NN cord-300061-l2pfl776 162 10 . . . cord-300061-l2pfl776 163 1 A a DT cord-300061-l2pfl776 163 2 biological biological JJ cord-300061-l2pfl776 163 3 process process NN cord-300061-l2pfl776 163 4 with with IN cord-300061-l2pfl776 163 5 a a DT cord-300061-l2pfl776 163 6 readout readout NN cord-300061-l2pfl776 163 7 that that WDT cord-300061-l2pfl776 163 8 is be VBZ cord-300061-l2pfl776 163 9 numerically numerically RB cord-300061-l2pfl776 163 10 small small JJ cord-300061-l2pfl776 163 11 does do VBZ cord-300061-l2pfl776 163 12 not not RB cord-300061-l2pfl776 163 13 necessarily necessarily RB cord-300061-l2pfl776 163 14 mean mean VB cord-300061-l2pfl776 163 15 it -PRON- PRP cord-300061-l2pfl776 163 16 is be VBZ cord-300061-l2pfl776 163 17 biologically biologically RB cord-300061-l2pfl776 163 18 unimportant unimportant JJ cord-300061-l2pfl776 163 19 . . . cord-300061-l2pfl776 164 1 For for IN cord-300061-l2pfl776 164 2 genomes genome NNS cord-300061-l2pfl776 164 3 , , , cord-300061-l2pfl776 164 4 according accord VBG cord-300061-l2pfl776 164 5 to to IN cord-300061-l2pfl776 164 6 PR2 PR2 NNP cord-300061-l2pfl776 164 7 , , , cord-300061-l2pfl776 164 8 a a DT cord-300061-l2pfl776 164 9 ≈ ≈ NNP cord-300061-l2pfl776 164 10 t t NN cord-300061-l2pfl776 164 11 and and CC cord-300061-l2pfl776 164 12 g g NNP cord-300061-l2pfl776 164 13 ≈ ≈ NNP cord-300061-l2pfl776 165 1 c. c. NNP cord-300061-l2pfl776 165 2 Based Based NNP cord-300061-l2pfl776 165 3 on on IN cord-300061-l2pfl776 165 4 equation equation NN cord-300061-l2pfl776 165 5 ( ( -LRB- cord-300061-l2pfl776 165 6 3 3 CD cord-300061-l2pfl776 165 7 ) ) -RRB- cord-300061-l2pfl776 165 8 , , , cord-300061-l2pfl776 165 9 without without IN cord-300061-l2pfl776 165 10 doing do VBG cord-300061-l2pfl776 165 11 PCA PCA NNP cord-300061-l2pfl776 165 12 , , , cord-300061-l2pfl776 165 13 obviously obviously RB cord-300061-l2pfl776 165 14 , , , cord-300061-l2pfl776 165 15 |z| |z| CD cord-300061-l2pfl776 165 16 > > XX cord-300061-l2pfl776 166 1 > > XX cord-300061-l2pfl776 167 1 |x| |x| CD cord-300061-l2pfl776 168 1 ≈ ≈ NNP cord-300061-l2pfl776 169 1 |y| |y| . cord-300061-l2pfl776 170 1 ≈ ≈ NNP cord-300061-l2pfl776 170 2 0 0 NFP cord-300061-l2pfl776 170 3 . . . cord-300061-l2pfl776 171 1 That that RB cord-300061-l2pfl776 171 2 is is RB cord-300061-l2pfl776 171 3 , , , cord-300061-l2pfl776 172 1 x x NNP cord-300061-l2pfl776 172 2 and and CC cord-300061-l2pfl776 172 3 y y NNP cord-300061-l2pfl776 172 4 components component NNS cord-300061-l2pfl776 172 5 are be VBP cord-300061-l2pfl776 172 6 small small JJ cord-300061-l2pfl776 172 7 numbers number NNS cord-300061-l2pfl776 172 8 that that WDT cord-300061-l2pfl776 172 9 are be VBP cord-300061-l2pfl776 172 10 close close JJ cord-300061-l2pfl776 172 11 to to IN cord-300061-l2pfl776 172 12 0 0 CD cord-300061-l2pfl776 172 13 . . . cord-300061-l2pfl776 173 1 However however RB cord-300061-l2pfl776 173 2 , , , cord-300061-l2pfl776 173 3 it -PRON- PRP cord-300061-l2pfl776 173 4 does do VBZ cord-300061-l2pfl776 173 5 not not RB cord-300061-l2pfl776 173 6 necessarily necessarily RB cord-300061-l2pfl776 173 7 mean mean VB cord-300061-l2pfl776 173 8 that that DT cord-300061-l2pfl776 173 9 x x : cord-300061-l2pfl776 173 10 and and CC cord-300061-l2pfl776 173 11 y y NNP cord-300061-l2pfl776 173 12 components component NNS cord-300061-l2pfl776 173 13 , , , cord-300061-l2pfl776 173 14 i.e. i.e. FW cord-300061-l2pfl776 173 15 , , , cord-300061-l2pfl776 173 16 variations variation NNS cord-300061-l2pfl776 173 17 of of IN cord-300061-l2pfl776 173 18 purine purine NN cord-300061-l2pfl776 173 19 / / SYM cord-300061-l2pfl776 173 20 pyrimidine pyrimidine NN cord-300061-l2pfl776 173 21 and and CC cord-300061-l2pfl776 173 22 amino amino NNS cord-300061-l2pfl776 173 23 / / SYM cord-300061-l2pfl776 173 24 keto keto JJ cord-300061-l2pfl776 173 25 bases basis NNS cord-300061-l2pfl776 173 26 , , , cord-300061-l2pfl776 173 27 respectively respectively RB cord-300061-l2pfl776 173 28 , , , cord-300061-l2pfl776 173 29 along along IN cord-300061-l2pfl776 173 30 the the DT cord-300061-l2pfl776 173 31 genome genome NN cord-300061-l2pfl776 173 32 , , , cord-300061-l2pfl776 173 33 are be VBP cord-300061-l2pfl776 173 34 not not RB cord-300061-l2pfl776 173 35 important important JJ cord-300061-l2pfl776 173 36 . . . cord-300061-l2pfl776 174 1 For for IN cord-300061-l2pfl776 174 2 instance instance NN cord-300061-l2pfl776 174 3 , , , cord-300061-l2pfl776 174 4 based base VBN cord-300061-l2pfl776 174 5 on on IN cord-300061-l2pfl776 174 6 x x SYM cord-300061-l2pfl776 174 7 and and CC cord-300061-l2pfl776 174 8 y y NNP cord-300061-l2pfl776 174 9 components component NNS cord-300061-l2pfl776 174 10 , , , cord-300061-l2pfl776 174 11 replication replication NN cord-300061-l2pfl776 174 12 origins origin NNS cord-300061-l2pfl776 174 13 have have VBP cord-300061-l2pfl776 174 14 been be VBN cord-300061-l2pfl776 174 15 located locate VBN cord-300061-l2pfl776 174 16 in in IN cord-300061-l2pfl776 174 17 more more JJR cord-300061-l2pfl776 174 18 than than IN cord-300061-l2pfl776 174 19 1000 1000 CD cord-300061-l2pfl776 174 20 bacterial bacterial JJ cord-300061-l2pfl776 174 21 genomes genome NNS cord-300061-l2pfl776 174 22 [ [ -LRB- cord-300061-l2pfl776 174 23 12 12 CD cord-300061-l2pfl776 174 24 , , , cord-300061-l2pfl776 174 25 13 13 CD cord-300061-l2pfl776 174 26 ] ] -RRB- cord-300061-l2pfl776 174 27 , , , cord-300061-l2pfl776 174 28 and and CC cord-300061-l2pfl776 174 29 also also RB cord-300061-l2pfl776 174 30 in in IN cord-300061-l2pfl776 174 31 archaeal archaeal JJ cord-300061-l2pfl776 174 32 genomes genome NNS cord-300061-l2pfl776 174 33 [ [ -LRB- cord-300061-l2pfl776 174 34 14 14 CD cord-300061-l2pfl776 174 35 ] ] -RRB- cord-300061-l2pfl776 174 36 . . . cord-300061-l2pfl776 175 1 For for IN cord-300061-l2pfl776 175 2 example example NN cord-300061-l2pfl776 175 3 , , , cord-300061-l2pfl776 175 4 for for IN cord-300061-l2pfl776 175 5 archaea archaea NNP cord-300061-l2pfl776 175 6 Sulfolobus Sulfolobus NNP cord-300061-l2pfl776 175 7 solfataricus solfataricus NNP cord-300061-l2pfl776 175 8 and and CC cord-300061-l2pfl776 175 9 Aeropyrum Aeropyrum NNP cord-300061-l2pfl776 175 10 pernix pernix NNP cord-300061-l2pfl776 175 11 , , , cord-300061-l2pfl776 175 12 analysis analysis NN cord-300061-l2pfl776 175 13 based base VBN cord-300061-l2pfl776 175 14 on on IN cord-300061-l2pfl776 175 15 x x SYM cord-300061-l2pfl776 175 16 and and CC cord-300061-l2pfl776 175 17 y y NNP cord-300061-l2pfl776 175 18 components component NNS cord-300061-l2pfl776 175 19 predicted predict VBD cord-300061-l2pfl776 175 20 multiple multiple JJ cord-300061-l2pfl776 175 21 replication replication NN cord-300061-l2pfl776 175 22 origins origin NNS cord-300061-l2pfl776 175 23 [ [ -LRB- cord-300061-l2pfl776 175 24 14 14 CD cord-300061-l2pfl776 175 25 , , , cord-300061-l2pfl776 175 26 15 15 CD cord-300061-l2pfl776 175 27 ] ] -RRB- cord-300061-l2pfl776 175 28 , , , cord-300061-l2pfl776 175 29 which which WDT cord-300061-l2pfl776 175 30 are be VBP cord-300061-l2pfl776 175 31 consistent consistent JJ cord-300061-l2pfl776 175 32 with with IN cord-300061-l2pfl776 175 33 later later JJ cord-300061-l2pfl776 175 34 experimental experimental JJ cord-300061-l2pfl776 175 35 results result NNS cord-300061-l2pfl776 175 36 [ [ -LRB- cord-300061-l2pfl776 175 37 16 16 CD cord-300061-l2pfl776 175 38 , , , cord-300061-l2pfl776 175 39 17 17 CD cord-300061-l2pfl776 175 40 ] ] -RRB- cord-300061-l2pfl776 175 41 . . . cord-300061-l2pfl776 176 1 Second second RB cord-300061-l2pfl776 176 2 , , , cord-300061-l2pfl776 176 3 Z z NN cord-300061-l2pfl776 176 4 - - HYPH cord-300061-l2pfl776 176 5 curve curve NN cord-300061-l2pfl776 176 6 can can MD cord-300061-l2pfl776 176 7 be be VB cord-300061-l2pfl776 176 8 used use VBN cord-300061-l2pfl776 176 9 in in IN cord-300061-l2pfl776 176 10 analyzing analyze VBG cord-300061-l2pfl776 176 11 any any DT cord-300061-l2pfl776 176 12 DNA dna NN cord-300061-l2pfl776 176 13 sequences sequence NNS cord-300061-l2pfl776 176 14 , , , cord-300061-l2pfl776 176 15 such such JJ cord-300061-l2pfl776 176 16 as as IN cord-300061-l2pfl776 176 17 protein protein NN cord-300061-l2pfl776 176 18 coding coding NN cord-300061-l2pfl776 176 19 genes gene NNS cord-300061-l2pfl776 176 20 [ [ -LRB- cord-300061-l2pfl776 176 21 18 18 CD cord-300061-l2pfl776 176 22 ] ] -RRB- cord-300061-l2pfl776 176 23 , , , cord-300061-l2pfl776 176 24 promoter promoter NN cord-300061-l2pfl776 176 25 sequences sequence NNS cord-300061-l2pfl776 176 26 [ [ -LRB- cord-300061-l2pfl776 176 27 19 19 CD cord-300061-l2pfl776 176 28 ] ] -RRB- cord-300061-l2pfl776 176 29 and and CC cord-300061-l2pfl776 176 30 translation translation NN cord-300061-l2pfl776 176 31 start start NN cord-300061-l2pfl776 176 32 sites site NNS cord-300061-l2pfl776 176 33 ( ( -LRB- cord-300061-l2pfl776 176 34 TSS TSS NNP cord-300061-l2pfl776 176 35 ) ) -RRB- cord-300061-l2pfl776 176 36 [ [ -LRB- cord-300061-l2pfl776 176 37 20 20 CD cord-300061-l2pfl776 176 38 ] ] -RRB- cord-300061-l2pfl776 176 39 . . . cord-300061-l2pfl776 177 1 Protein protein NN cord-300061-l2pfl776 177 2 coding coding NN cord-300061-l2pfl776 177 3 genes gene NNS cord-300061-l2pfl776 177 4 or or CC cord-300061-l2pfl776 177 5 DNA dna NN cord-300061-l2pfl776 177 6 sequence sequence NN cord-300061-l2pfl776 177 7 segments segment NNS cord-300061-l2pfl776 177 8 in in IN cord-300061-l2pfl776 177 9 various various JJ cord-300061-l2pfl776 177 10 species specie NNS cord-300061-l2pfl776 177 11 do do VBP cord-300061-l2pfl776 177 12 not not RB cord-300061-l2pfl776 177 13 necessarily necessarily RB cord-300061-l2pfl776 177 14 have have VB cord-300061-l2pfl776 177 15 the the DT cord-300061-l2pfl776 177 16 same same JJ cord-300061-l2pfl776 177 17 nucleotide nucleotide JJ cord-300061-l2pfl776 177 18 variation variation NN cord-300061-l2pfl776 177 19 patterns pattern NNS cord-300061-l2pfl776 177 20 as as IN cord-300061-l2pfl776 177 21 the the DT cord-300061-l2pfl776 177 22 one one CD cord-300061-l2pfl776 177 23 in in IN cord-300061-l2pfl776 177 24 the the DT cord-300061-l2pfl776 177 25 235 235 CD cord-300061-l2pfl776 177 26 bacterial bacterial JJ cord-300061-l2pfl776 177 27 genomes genome NNS cord-300061-l2pfl776 177 28 , , , cord-300061-l2pfl776 177 29 the the DT cord-300061-l2pfl776 177 30 basis basis NN cord-300061-l2pfl776 177 31 of of IN cord-300061-l2pfl776 177 32 their -PRON- PRP$ cord-300061-l2pfl776 177 33 conclusion conclusion NN cord-300061-l2pfl776 177 34 . . . cord-300061-l2pfl776 178 1 For for IN cord-300061-l2pfl776 178 2 instance instance NN cord-300061-l2pfl776 178 3 , , , cord-300061-l2pfl776 178 4 based base VBN cord-300061-l2pfl776 178 5 on on IN cord-300061-l2pfl776 178 6 Z z NN cord-300061-l2pfl776 178 7 - - HYPH cord-300061-l2pfl776 178 8 curve curve NN cord-300061-l2pfl776 178 9 behaviors behavior NNS cord-300061-l2pfl776 178 10 , , , cord-300061-l2pfl776 178 11 bacterial bacterial JJ cord-300061-l2pfl776 178 12 TSS tss NN cord-300061-l2pfl776 178 13 can can MD cord-300061-l2pfl776 178 14 be be VB cord-300061-l2pfl776 178 15 reliably reliably RB cord-300061-l2pfl776 178 16 predicted predict VBN cord-300061-l2pfl776 178 17 , , , cord-300061-l2pfl776 178 18 and and CC cord-300061-l2pfl776 178 19 for for IN cord-300061-l2pfl776 178 20 sequences sequence NNS cord-300061-l2pfl776 178 21 around around IN cord-300061-l2pfl776 178 22 bacterial bacterial JJ cord-300061-l2pfl776 178 23 TSS TSS NNP cord-300061-l2pfl776 178 24 , , , cord-300061-l2pfl776 178 25 x x SYM cord-300061-l2pfl776 178 26 and and CC cord-300061-l2pfl776 178 27 y y NNP cord-300061-l2pfl776 178 28 components component NNS cord-300061-l2pfl776 178 29 in in IN cord-300061-l2pfl776 178 30 fact fact NN cord-300061-l2pfl776 178 31 have have VBP cord-300061-l2pfl776 178 32 more more JJR cord-300061-l2pfl776 178 33 variations variation NNS cord-300061-l2pfl776 178 34 than than IN cord-300061-l2pfl776 178 35 the the DT cord-300061-l2pfl776 178 36 z z NNP cord-300061-l2pfl776 178 37 component component NN cord-300061-l2pfl776 178 38 , , , cord-300061-l2pfl776 178 39 in in IN cord-300061-l2pfl776 178 40 contrast contrast NN cord-300061-l2pfl776 178 41 to to IN cord-300061-l2pfl776 178 42 the the DT cord-300061-l2pfl776 178 43 variation variation NN cord-300061-l2pfl776 178 44 pattern pattern NN cord-300061-l2pfl776 178 45 of of IN cord-300061-l2pfl776 178 46 bacterial bacterial JJ cord-300061-l2pfl776 178 47 genomes genome NNS cord-300061-l2pfl776 178 48 [ [ -LRB- cord-300061-l2pfl776 178 49 20 20 CD cord-300061-l2pfl776 178 50 ] ] -RRB- cord-300061-l2pfl776 178 51 . . . cord-300061-l2pfl776 179 1 Z z NN cord-300061-l2pfl776 179 2 - - HYPH cord-300061-l2pfl776 179 3 curve curve NN cord-300061-l2pfl776 179 4 based base VBN cord-300061-l2pfl776 179 5 algorithms algorithm NNS cord-300061-l2pfl776 179 6 have have VBP cord-300061-l2pfl776 179 7 been be VBN cord-300061-l2pfl776 179 8 successfully successfully RB cord-300061-l2pfl776 179 9 used use VBN cord-300061-l2pfl776 179 10 in in IN cord-300061-l2pfl776 179 11 recognizing recognize VBG cord-300061-l2pfl776 179 12 protein protein NN cord-300061-l2pfl776 179 13 coding code VBG cord-300061-l2pfl776 179 14 genes gene NNS cord-300061-l2pfl776 179 15 in in IN cord-300061-l2pfl776 179 16 genomes genome NNS cord-300061-l2pfl776 179 17 of of IN cord-300061-l2pfl776 179 18 budding bud VBG cord-300061-l2pfl776 179 19 yeast yeast NN cord-300061-l2pfl776 179 20 [ [ -LRB- cord-300061-l2pfl776 179 21 18 18 CD cord-300061-l2pfl776 179 22 ] ] -RRB- cord-300061-l2pfl776 179 23 , , , cord-300061-l2pfl776 179 24 bacteria bacteria NNS cord-300061-l2pfl776 179 25 and and CC cord-300061-l2pfl776 179 26 archaea archaea JJ cord-300061-l2pfl776 179 27 [ [ -LRB- cord-300061-l2pfl776 179 28 21 21 CD cord-300061-l2pfl776 179 29 ] ] -RRB- cord-300061-l2pfl776 179 30 , , , cord-300061-l2pfl776 179 31 viruses virus NNS cord-300061-l2pfl776 179 32 and and CC cord-300061-l2pfl776 179 33 phages phage NNS cord-300061-l2pfl776 179 34 [ [ -LRB- cord-300061-l2pfl776 179 35 22 22 CD cord-300061-l2pfl776 179 36 ] ] -RRB- cord-300061-l2pfl776 179 37 , , , cord-300061-l2pfl776 179 38 especially especially RB cord-300061-l2pfl776 179 39 coronaviruses coronaviruses NNP cord-300061-l2pfl776 179 40 [ [ -LRB- cord-300061-l2pfl776 179 41 23 23 CD cord-300061-l2pfl776 179 42 ] ] -RRB- cord-300061-l2pfl776 179 43 and and CC cord-300061-l2pfl776 179 44 in in IN cord-300061-l2pfl776 179 45 recognizing recognize VBG cord-300061-l2pfl776 179 46 short short JJ cord-300061-l2pfl776 179 47 coding coding NN cord-300061-l2pfl776 179 48 sequences sequence NNS cord-300061-l2pfl776 179 49 of of IN cord-300061-l2pfl776 179 50 human human JJ cord-300061-l2pfl776 179 51 genes gene NNS cord-300061-l2pfl776 179 52 [ [ -LRB- cord-300061-l2pfl776 179 53 24 24 CD cord-300061-l2pfl776 179 54 ] ] -RRB- cord-300061-l2pfl776 179 55 . . . cord-300061-l2pfl776 180 1 In in IN cord-300061-l2pfl776 180 2 all all PDT cord-300061-l2pfl776 180 3 these these DT cord-300061-l2pfl776 180 4 algorithms algorithm NNS cord-300061-l2pfl776 180 5 , , , cord-300061-l2pfl776 180 6 x x SYM cord-300061-l2pfl776 180 7 and and CC cord-300061-l2pfl776 180 8 y y NNP cord-300061-l2pfl776 180 9 components component NNS cord-300061-l2pfl776 180 10 are be VBP cord-300061-l2pfl776 180 11 absolutely absolutely RB cord-300061-l2pfl776 180 12 needed need VBN cord-300061-l2pfl776 180 13 to to TO cord-300061-l2pfl776 180 14 achieve achieve VB cord-300061-l2pfl776 180 15 high high JJ cord-300061-l2pfl776 180 16 gene gene NN cord-300061-l2pfl776 180 17 recognition recognition NN cord-300061-l2pfl776 180 18 accuracy accuracy NN cord-300061-l2pfl776 180 19 . . . cord-300061-l2pfl776 181 1 In in IN cord-300061-l2pfl776 181 2 this this DT cord-300061-l2pfl776 181 3 section section NN cord-300061-l2pfl776 181 4 , , , cord-300061-l2pfl776 181 5 the the DT cord-300061-l2pfl776 181 6 major major JJ cord-300061-l2pfl776 181 7 mistake mistake NN cord-300061-l2pfl776 181 8 ( ( -LRB- cord-300061-l2pfl776 181 9 among among IN cord-300061-l2pfl776 181 10 some some DT cord-300061-l2pfl776 181 11 others other NNS cord-300061-l2pfl776 181 12 , , , cord-300061-l2pfl776 181 13 such such JJ cord-300061-l2pfl776 181 14 as as IN cord-300061-l2pfl776 181 15 incorrectly incorrectly RB cord-300061-l2pfl776 181 16 extrapolating extrapolate VBG cord-300061-l2pfl776 181 17 a a DT cord-300061-l2pfl776 181 18 result result NN cord-300061-l2pfl776 181 19 based base VBN cord-300061-l2pfl776 181 20 on on IN cord-300061-l2pfl776 181 21 a a DT cord-300061-l2pfl776 181 22 subset subset NN cord-300061-l2pfl776 181 23 of of IN cord-300061-l2pfl776 181 24 bacterial bacterial JJ cord-300061-l2pfl776 181 25 genomes genome NNS cord-300061-l2pfl776 181 26 to to IN cord-300061-l2pfl776 181 27 those those DT cord-300061-l2pfl776 181 28 for for IN cord-300061-l2pfl776 181 29 all all DT cord-300061-l2pfl776 181 30 DNA dna NN cord-300061-l2pfl776 181 31 sequences sequence NNS cord-300061-l2pfl776 181 32 ) ) -RRB- cord-300061-l2pfl776 181 33 of of IN cord-300061-l2pfl776 181 34 Elhaik Elhaik NNP cord-300061-l2pfl776 181 35 et et NNP cord-300061-l2pfl776 181 36 al al NNP cord-300061-l2pfl776 181 37 . . NNP cord-300061-l2pfl776 181 38 is be VBZ cord-300061-l2pfl776 181 39 the the DT cord-300061-l2pfl776 181 40 confusion confusion NN cord-300061-l2pfl776 181 41 of of IN cord-300061-l2pfl776 181 42 numeral numeral JJ cord-300061-l2pfl776 181 43 smallness smallness NN cord-300061-l2pfl776 181 44 with with IN cord-300061-l2pfl776 181 45 biological biological JJ cord-300061-l2pfl776 181 46 insignificance insignificance NN cord-300061-l2pfl776 181 47 . . . cord-300061-l2pfl776 182 1 Variations variation NNS cord-300061-l2pfl776 182 2 of of IN cord-300061-l2pfl776 182 3 purine purine NN cord-300061-l2pfl776 182 4 / / SYM cord-300061-l2pfl776 182 5 pyrimidine pyrimidine NN cord-300061-l2pfl776 182 6 and and CC cord-300061-l2pfl776 182 7 amino amino NNS cord-300061-l2pfl776 182 8 / / SYM cord-300061-l2pfl776 182 9 keto keto NNP cord-300061-l2pfl776 182 10 bases basis NNS cord-300061-l2pfl776 182 11 ( ( -LRB- cord-300061-l2pfl776 182 12 x x SYM cord-300061-l2pfl776 182 13 and and CC cord-300061-l2pfl776 182 14 y y NNP cord-300061-l2pfl776 182 15 components component NNS cord-300061-l2pfl776 182 16 ) ) -RRB- cord-300061-l2pfl776 182 17 should should MD cord-300061-l2pfl776 182 18 not not RB cord-300061-l2pfl776 182 19 be be VB cord-300061-l2pfl776 182 20 disregarded disregard VBN cord-300061-l2pfl776 182 21 and and CC cord-300061-l2pfl776 182 22 treated treat VBN cord-300061-l2pfl776 182 23 as as IN cord-300061-l2pfl776 182 24 " " `` cord-300061-l2pfl776 182 25 little little JJ cord-300061-l2pfl776 182 26 use use NN cord-300061-l2pfl776 182 27 " " '' cord-300061-l2pfl776 182 28 only only RB cord-300061-l2pfl776 182 29 because because IN cord-300061-l2pfl776 182 30 they -PRON- PRP cord-300061-l2pfl776 182 31 could could MD cord-300061-l2pfl776 182 32 be be VB cord-300061-l2pfl776 182 33 small small JJ cord-300061-l2pfl776 182 34 in in IN cord-300061-l2pfl776 182 35 magnitude magnitude NN cord-300061-l2pfl776 182 36 ; ; : cord-300061-l2pfl776 182 37 in in IN cord-300061-l2pfl776 182 38 contrast contrast NN cord-300061-l2pfl776 182 39 , , , cord-300061-l2pfl776 182 40 they -PRON- PRP cord-300061-l2pfl776 182 41 are be VBP cord-300061-l2pfl776 182 42 important important JJ cord-300061-l2pfl776 182 43 and and CC cord-300061-l2pfl776 182 44 useful useful JJ cord-300061-l2pfl776 182 45 . . . cord-300061-l2pfl776 183 1 As as IN cord-300061-l2pfl776 183 2 mentioned mention VBN cord-300061-l2pfl776 183 3 above above RB cord-300061-l2pfl776 183 4 , , , cord-300061-l2pfl776 183 5 based base VBN cord-300061-l2pfl776 183 6 on on IN cord-300061-l2pfl776 183 7 x x SYM cord-300061-l2pfl776 183 8 and and CC cord-300061-l2pfl776 183 9 y y NNP cord-300061-l2pfl776 183 10 components component NNS cord-300061-l2pfl776 183 11 , , , cord-300061-l2pfl776 183 12 a a DT cord-300061-l2pfl776 183 13 large large JJ cord-300061-l2pfl776 183 14 number number NN cord-300061-l2pfl776 183 15 of of IN cord-300061-l2pfl776 183 16 replication replication NN cord-300061-l2pfl776 183 17 origins origin NNS cord-300061-l2pfl776 183 18 have have VBP cord-300061-l2pfl776 183 19 been be VBN cord-300061-l2pfl776 183 20 located locate VBN cord-300061-l2pfl776 183 21 in in IN cord-300061-l2pfl776 183 22 both both DT cord-300061-l2pfl776 183 23 bacterial bacterial JJ cord-300061-l2pfl776 183 24 [ [ -LRB- cord-300061-l2pfl776 183 25 12 12 CD cord-300061-l2pfl776 183 26 , , , cord-300061-l2pfl776 183 27 13 13 CD cord-300061-l2pfl776 183 28 ] ] -RRB- cord-300061-l2pfl776 183 29 and and CC cord-300061-l2pfl776 183 30 archaeal archaeal JJ cord-300061-l2pfl776 183 31 genomes genome NNS cord-300061-l2pfl776 183 32 [ [ -LRB- cord-300061-l2pfl776 183 33 14 14 CD cord-300061-l2pfl776 183 34 ] ] -RRB- cord-300061-l2pfl776 183 35 . . . cord-300061-l2pfl776 184 1 The the DT cord-300061-l2pfl776 184 2 x x NN cord-300061-l2pfl776 184 3 and and CC cord-300061-l2pfl776 184 4 y y NNP cord-300061-l2pfl776 184 5 components component NNS cord-300061-l2pfl776 184 6 play play VBP cord-300061-l2pfl776 184 7 an an DT cord-300061-l2pfl776 184 8 absolutely absolutely RB cord-300061-l2pfl776 184 9 indispensable indispensable JJ cord-300061-l2pfl776 184 10 role role NN cord-300061-l2pfl776 184 11 in in IN cord-300061-l2pfl776 184 12 Z z NN cord-300061-l2pfl776 184 13 - - HYPH cord-300061-l2pfl776 184 14 curve curve NN cord-300061-l2pfl776 184 15 based base VBN cord-300061-l2pfl776 184 16 gene gene NN cord-300061-l2pfl776 184 17 finding find VBG cord-300061-l2pfl776 184 18 algorithms algorithm NNS cord-300061-l2pfl776 184 19 , , , cord-300061-l2pfl776 184 20 which which WDT cord-300061-l2pfl776 184 21 have have VBP cord-300061-l2pfl776 184 22 been be VBN cord-300061-l2pfl776 184 23 successfully successfully RB cord-300061-l2pfl776 184 24 applied apply VBN cord-300061-l2pfl776 184 25 in in IN cord-300061-l2pfl776 184 26 recognizing recognize VBG cord-300061-l2pfl776 184 27 protein protein NN cord-300061-l2pfl776 184 28 coding code VBG cord-300061-l2pfl776 184 29 genes gene NNS cord-300061-l2pfl776 184 30 in in RP cord-300061-l2pfl776 184 31 , , , cord-300061-l2pfl776 184 32 to to TO cord-300061-l2pfl776 184 33 name name VB cord-300061-l2pfl776 184 34 a a DT cord-300061-l2pfl776 184 35 few few JJ cord-300061-l2pfl776 184 36 , , , cord-300061-l2pfl776 184 37 the the DT cord-300061-l2pfl776 184 38 genomes genome NNS cord-300061-l2pfl776 184 39 of of IN cord-300061-l2pfl776 184 40 L. L. NNP cord-300061-l2pfl776 184 41 interrogans interrogan NNS cord-300061-l2pfl776 184 42 Lai Lai NNP cord-300061-l2pfl776 184 43 [ [ -LRB- cord-300061-l2pfl776 184 44 25 25 CD cord-300061-l2pfl776 184 45 ] ] -RRB- cord-300061-l2pfl776 184 46 , , , cord-300061-l2pfl776 184 47 B. B. NNP cord-300061-l2pfl776 184 48 amyloliquefaciens amyloliquefaciens NNP cord-300061-l2pfl776 184 49 FZB42 FZB42 NNP cord-300061-l2pfl776 184 50 [ [ -LRB- cord-300061-l2pfl776 184 51 26 26 CD cord-300061-l2pfl776 184 52 ] ] -RRB- cord-300061-l2pfl776 184 53 , , , cord-300061-l2pfl776 184 54 B. B. NNP cord-300061-l2pfl776 184 55 thuringiensis thuringiensis NNP cord-300061-l2pfl776 185 1 BMB171 BMB171 NNP cord-300061-l2pfl776 185 2 [ [ -LRB- cord-300061-l2pfl776 185 3 27 27 CD cord-300061-l2pfl776 185 4 ] ] -RRB- cord-300061-l2pfl776 185 5 , , , cord-300061-l2pfl776 185 6 A. a. NN cord-300061-l2pfl776 185 7 mediterranei mediterranei JJ cord-300061-l2pfl776 185 8 U32 U32 NNP cord-300061-l2pfl776 185 9 [ [ -LRB- cord-300061-l2pfl776 185 10 28 28 CD cord-300061-l2pfl776 185 11 ] ] -RRB- cord-300061-l2pfl776 185 12 , , . cord-300061-l2pfl776 186 1 M. M. NNP cord-300061-l2pfl776 186 2 tuberculosis tuberculosis NN cord-300061-l2pfl776 186 3 H37Ra H37Ra NNP cord-300061-l2pfl776 186 4 [ [ -LRB- cord-300061-l2pfl776 186 5 29 29 CD cord-300061-l2pfl776 186 6 ] ] -RRB- cord-300061-l2pfl776 186 7 , , , cord-300061-l2pfl776 186 8 Drosophila Drosophila NNP cord-300061-l2pfl776 186 9 [ [ -LRB- cord-300061-l2pfl776 186 10 30 30 CD cord-300061-l2pfl776 186 11 ] ] -RRB- cord-300061-l2pfl776 186 12 , , , cord-300061-l2pfl776 186 13 new new JJ cord-300061-l2pfl776 186 14 human human JJ cord-300061-l2pfl776 186 15 coronaviruses coronaviruse NNS cord-300061-l2pfl776 187 1 HCoV HCoV NNP cord-300061-l2pfl776 188 1 -NL63 -NL63 : cord-300061-l2pfl776 188 2 [ [ -LRB- cord-300061-l2pfl776 188 3 31 31 CD cord-300061-l2pfl776 188 4 ] ] -RRB- cord-300061-l2pfl776 188 5 and and CC cord-300061-l2pfl776 188 6 HKU1 HKU1 NNP cord-300061-l2pfl776 188 7 [ [ -LRB- cord-300061-l2pfl776 188 8 32 32 CD cord-300061-l2pfl776 188 9 ] ] -RRB- cord-300061-l2pfl776 188 10 , , , cord-300061-l2pfl776 188 11 four four CD cord-300061-l2pfl776 188 12 coronaviruses coronaviruse NNS cord-300061-l2pfl776 188 13 from from IN cord-300061-l2pfl776 188 14 bats bat NNS cord-300061-l2pfl776 188 15 [ [ -LRB- cord-300061-l2pfl776 188 16 33 33 CD cord-300061-l2pfl776 188 17 ] ] -RRB- cord-300061-l2pfl776 188 18 , , , cord-300061-l2pfl776 188 19 new new JJ cord-300061-l2pfl776 188 20 phages phage NNS cord-300061-l2pfl776 188 21 Rtp Rtp NNP cord-300061-l2pfl776 188 22 in in IN cord-300061-l2pfl776 188 23 E. E. NNP cord-300061-l2pfl776 188 24 coli coli NNS cord-300061-l2pfl776 188 25 [ [ -LRB- cord-300061-l2pfl776 188 26 34 34 CD cord-300061-l2pfl776 188 27 ] ] -RRB- cord-300061-l2pfl776 188 28 and and CC cord-300061-l2pfl776 188 29 in in IN cord-300061-l2pfl776 188 30 a a DT cord-300061-l2pfl776 188 31 pandemic pandemic NN cord-300061-l2pfl776 188 32 V. V. NNP cord-300061-l2pfl776 188 33 parahaemolyticus parahaemolyticus NNP cord-300061-l2pfl776 188 34 O3 o3 NN cord-300061-l2pfl776 188 35 : : : cord-300061-l2pfl776 189 1 K6 K6 NNP cord-300061-l2pfl776 189 2 strain strain VBP cord-300061-l2pfl776 189 3 [ [ -LRB- cord-300061-l2pfl776 189 4 35 35 CD cord-300061-l2pfl776 189 5 ] ] -RRB- cord-300061-l2pfl776 189 6 . . . cord-300061-l2pfl776 190 1 In in IN cord-300061-l2pfl776 190 2 many many JJ cord-300061-l2pfl776 190 3 cases case NNS cord-300061-l2pfl776 190 4 the the DT cord-300061-l2pfl776 190 5 statements statement NNS cord-300061-l2pfl776 190 6 by by IN cord-300061-l2pfl776 190 7 themselves -PRON- PRP cord-300061-l2pfl776 190 8 [ [ -LRB- cord-300061-l2pfl776 190 9 3 3 CD cord-300061-l2pfl776 190 10 , , , cord-300061-l2pfl776 190 11 5 5 CD cord-300061-l2pfl776 190 12 ] ] -RRB- cord-300061-l2pfl776 190 13 make make VB cord-300061-l2pfl776 190 14 little little JJ cord-300061-l2pfl776 190 15 sense sense NN cord-300061-l2pfl776 190 16 . . . cord-300061-l2pfl776 191 1 Below below RB cord-300061-l2pfl776 191 2 are be VBP cord-300061-l2pfl776 191 3 some some DT cord-300061-l2pfl776 191 4 examples example NNS cord-300061-l2pfl776 191 5 . . . cord-300061-l2pfl776 192 1 1 1 LS cord-300061-l2pfl776 192 2 . . . cord-300061-l2pfl776 193 1 " " '' cord-300061-l2pfl776 194 1 The the DT cord-300061-l2pfl776 194 2 genome genome NN cord-300061-l2pfl776 194 3 order order NN cord-300061-l2pfl776 194 4 index index NN cord-300061-l2pfl776 194 5 was be VBD cord-300061-l2pfl776 194 6 selected select VBN cord-300061-l2pfl776 194 7 as as IN cord-300061-l2pfl776 194 8 a a DT cord-300061-l2pfl776 194 9 case case NN cord-300061-l2pfl776 194 10 study study NN cord-300061-l2pfl776 194 11 to to IN cord-300061-l2pfl776 194 12 the the DT cord-300061-l2pfl776 194 13 usefulness usefulness NN cord-300061-l2pfl776 194 14 of of IN cord-300061-l2pfl776 194 15 the the DT cord-300061-l2pfl776 194 16 Z z NN cord-300061-l2pfl776 194 17 - - HYPH cord-300061-l2pfl776 194 18 curve curve NN cord-300061-l2pfl776 194 19 method method NN cord-300061-l2pfl776 194 20 . . . cord-300061-l2pfl776 195 1 " " `` cord-300061-l2pfl776 195 2 S S NNP cord-300061-l2pfl776 195 3 is be VBZ cord-300061-l2pfl776 195 4 a a DT cord-300061-l2pfl776 195 5 statistical statistical JJ cord-300061-l2pfl776 195 6 quantity quantity NN cord-300061-l2pfl776 195 7 ( ( -LRB- cord-300061-l2pfl776 195 8 one one CD cord-300061-l2pfl776 195 9 single single JJ cord-300061-l2pfl776 195 10 number number NN cord-300061-l2pfl776 195 11 ) ) -RRB- cord-300061-l2pfl776 195 12 , , , cord-300061-l2pfl776 195 13 while while IN cord-300061-l2pfl776 195 14 Z z NN cord-300061-l2pfl776 195 15 - - HYPH cord-300061-l2pfl776 195 16 curve curve NN cord-300061-l2pfl776 195 17 is be VBZ cord-300061-l2pfl776 195 18 a a DT cord-300061-l2pfl776 195 19 3-dimensional 3-dimensional CD cord-300061-l2pfl776 195 20 curve curve NN cord-300061-l2pfl776 195 21 that that WDT cord-300061-l2pfl776 195 22 constitutes constitute VBZ cord-300061-l2pfl776 195 23 a a DT cord-300061-l2pfl776 195 24 one one CD cord-300061-l2pfl776 195 25 - - HYPH cord-300061-l2pfl776 195 26 to to IN cord-300061-l2pfl776 195 27 - - HYPH cord-300061-l2pfl776 195 28 one one CD cord-300061-l2pfl776 195 29 correspondence correspondence NN cord-300061-l2pfl776 195 30 of of IN cord-300061-l2pfl776 195 31 a a DT cord-300061-l2pfl776 195 32 DNA dna NN cord-300061-l2pfl776 195 33 sequence sequence NN cord-300061-l2pfl776 195 34 ( ( -LRB- cord-300061-l2pfl776 195 35 a a DT cord-300061-l2pfl776 195 36 series series NN cord-300061-l2pfl776 195 37 of of IN cord-300061-l2pfl776 195 38 3-D 3-D NNP cord-300061-l2pfl776 195 39 coordinates coordinate NNS cord-300061-l2pfl776 195 40 ) ) -RRB- cord-300061-l2pfl776 195 41 . . . cord-300061-l2pfl776 196 1 S S NNP cord-300061-l2pfl776 196 2 is be VBZ cord-300061-l2pfl776 196 3 not not RB cord-300061-l2pfl776 196 4 Z z NN cord-300061-l2pfl776 196 5 - - HYPH cord-300061-l2pfl776 196 6 curve curve NN cord-300061-l2pfl776 196 7 , , , cord-300061-l2pfl776 196 8 and and CC cord-300061-l2pfl776 196 9 S S NNP cord-300061-l2pfl776 196 10 can can MD cord-300061-l2pfl776 196 11 not not RB cord-300061-l2pfl776 196 12 be be VB cord-300061-l2pfl776 196 13 used use VBN cord-300061-l2pfl776 196 14 as as IN cord-300061-l2pfl776 196 15 a a DT cord-300061-l2pfl776 196 16 case case NN cord-300061-l2pfl776 196 17 study study NN cord-300061-l2pfl776 196 18 of of IN cord-300061-l2pfl776 196 19 Z z NN cord-300061-l2pfl776 196 20 - - HYPH cord-300061-l2pfl776 196 21 curve curve NN cord-300061-l2pfl776 196 22 . . . cord-300061-l2pfl776 197 1 2 2 LS cord-300061-l2pfl776 197 2 . . . cord-300061-l2pfl776 198 1 " " `` cord-300061-l2pfl776 198 2 We -PRON- PRP cord-300061-l2pfl776 198 3 must must MD cord-300061-l2pfl776 198 4 conclude conclude VB cord-300061-l2pfl776 198 5 that that IN cord-300061-l2pfl776 198 6 both both CC cord-300061-l2pfl776 198 7 the the DT cord-300061-l2pfl776 198 8 Z z NN cord-300061-l2pfl776 198 9 - - HYPH cord-300061-l2pfl776 198 10 curve curve NN cord-300061-l2pfl776 198 11 and and CC cord-300061-l2pfl776 198 12 S S NNP cord-300061-l2pfl776 198 13 are be VBP cord-300061-l2pfl776 198 14 over over IN cord-300061-l2pfl776 198 15 complicated complicate VBN cord-300061-l2pfl776 198 16 measures measure NNS cord-300061-l2pfl776 198 17 to to IN cord-300061-l2pfl776 198 18 GC GC NNP cord-300061-l2pfl776 198 19 content content NN cord-300061-l2pfl776 198 20 and and CC cord-300061-l2pfl776 198 21 Shannon Shannon NNP cord-300061-l2pfl776 198 22 H H NNP cord-300061-l2pfl776 198 23 index index NN cord-300061-l2pfl776 198 24 , , , cord-300061-l2pfl776 198 25 respectively respectively RB cord-300061-l2pfl776 198 26 . . . cord-300061-l2pfl776 198 27 " " '' cord-300061-l2pfl776 199 1 Z z NN cord-300061-l2pfl776 199 2 - - HYPH cord-300061-l2pfl776 199 3 curve curve NN cord-300061-l2pfl776 199 4 is be VBZ cord-300061-l2pfl776 199 5 not not RB cord-300061-l2pfl776 199 6 a a DT cord-300061-l2pfl776 199 7 measure measure NN cord-300061-l2pfl776 199 8 of of IN cord-300061-l2pfl776 199 9 GC GC NNP cord-300061-l2pfl776 199 10 content content NN cord-300061-l2pfl776 199 11 . . . cord-300061-l2pfl776 200 1 S S NNP cord-300061-l2pfl776 200 2 is be VBZ cord-300061-l2pfl776 200 3 not not RB cord-300061-l2pfl776 200 4 a a DT cord-300061-l2pfl776 200 5 measure measure NN cord-300061-l2pfl776 200 6 of of IN cord-300061-l2pfl776 200 7 Shannon Shannon NNP cord-300061-l2pfl776 200 8 H H NNP cord-300061-l2pfl776 200 9 index index NN cord-300061-l2pfl776 200 10 . . . cord-300061-l2pfl776 201 1 If if IN cord-300061-l2pfl776 201 2 Zcurve Zcurve NNP cord-300061-l2pfl776 201 3 were be VBD cord-300061-l2pfl776 201 4 a a DT cord-300061-l2pfl776 201 5 measure measure NN cord-300061-l2pfl776 201 6 of of IN cord-300061-l2pfl776 201 7 GC GC NNP cord-300061-l2pfl776 201 8 content content NN cord-300061-l2pfl776 201 9 , , , cord-300061-l2pfl776 201 10 it -PRON- PRP cord-300061-l2pfl776 201 11 would would MD cord-300061-l2pfl776 201 12 be be VB cord-300061-l2pfl776 201 13 striking strike VBG cord-300061-l2pfl776 201 14 that that IN cord-300061-l2pfl776 201 15 gene gene NN cord-300061-l2pfl776 201 16 recognition recognition NN cord-300061-l2pfl776 201 17 can can MD cord-300061-l2pfl776 201 18 be be VB cord-300061-l2pfl776 201 19 achieved achieve VBN cord-300061-l2pfl776 201 20 with with IN cord-300061-l2pfl776 201 21 a a DT cord-300061-l2pfl776 201 22 high high JJ cord-300061-l2pfl776 201 23 accuracy accuracy NN cord-300061-l2pfl776 201 24 [ [ -LRB- cord-300061-l2pfl776 201 25 18 18 CD cord-300061-l2pfl776 201 26 , , , cord-300061-l2pfl776 201 27 21 21 CD cord-300061-l2pfl776 201 28 , , , cord-300061-l2pfl776 201 29 22 22 CD cord-300061-l2pfl776 201 30 , , , cord-300061-l2pfl776 201 31 24 24 CD cord-300061-l2pfl776 201 32 ] ] -RRB- cord-300061-l2pfl776 201 33 based base VBN cord-300061-l2pfl776 201 34 solely solely RB cord-300061-l2pfl776 201 35 on on IN cord-300061-l2pfl776 201 36 GC GC NNP cord-300061-l2pfl776 201 37 content content NN cord-300061-l2pfl776 201 38 . . . cord-300061-l2pfl776 202 1 3 3 LS cord-300061-l2pfl776 202 2 . . . cord-300061-l2pfl776 203 1 " " `` cord-300061-l2pfl776 203 2 the the DT cord-300061-l2pfl776 203 3 dimension dimension NN cord-300061-l2pfl776 203 4 stands stand VBZ cord-300061-l2pfl776 203 5 for for IN cord-300061-l2pfl776 203 6 GC GC NNP cord-300061-l2pfl776 203 7 content content NN cord-300061-l2pfl776 203 8 alone alone RB cord-300061-l2pfl776 203 9 suffices suffice VBZ cord-300061-l2pfl776 203 10 to to TO cord-300061-l2pfl776 203 11 represent represent VB cord-300061-l2pfl776 203 12 any any DT cord-300061-l2pfl776 203 13 given give VBN cord-300061-l2pfl776 203 14 genome genome NN cord-300061-l2pfl776 203 15 . . . cord-300061-l2pfl776 203 16 " " '' cord-300061-l2pfl776 204 1 GC GC NNP cord-300061-l2pfl776 204 2 content content NN cord-300061-l2pfl776 204 3 alone alone RB cord-300061-l2pfl776 204 4 does do VBZ cord-300061-l2pfl776 204 5 not not RB cord-300061-l2pfl776 204 6 suffice suffice VB cord-300061-l2pfl776 204 7 to to TO cord-300061-l2pfl776 204 8 represent represent VB cord-300061-l2pfl776 204 9 any any DT cord-300061-l2pfl776 204 10 given give VBN cord-300061-l2pfl776 204 11 genome genome NN cord-300061-l2pfl776 204 12 , , , cord-300061-l2pfl776 204 13 simply simply RB cord-300061-l2pfl776 204 14 because because IN cord-300061-l2pfl776 204 15 the the DT cord-300061-l2pfl776 204 16 genome genome NN cord-300061-l2pfl776 204 17 is be VBZ cord-300061-l2pfl776 204 18 composed compose VBN cord-300061-l2pfl776 204 19 of of IN cord-300061-l2pfl776 204 20 4 4 CD cord-300061-l2pfl776 204 21 kinds kind NNS cord-300061-l2pfl776 204 22 of of IN cord-300061-l2pfl776 204 23 nucleotides nucleotide NNS cord-300061-l2pfl776 204 24 , , , cord-300061-l2pfl776 204 25 and and CC cord-300061-l2pfl776 204 26 distributions distribution NNS cord-300061-l2pfl776 204 27 of of IN cord-300061-l2pfl776 204 28 purine purine NN cord-300061-l2pfl776 204 29 / / SYM cord-300061-l2pfl776 204 30 pyrimidine pyrimidine NN cord-300061-l2pfl776 204 31 and and CC cord-300061-l2pfl776 204 32 amino/ amino/ JJ cord-300061-l2pfl776 204 33 keto keto NNP cord-300061-l2pfl776 204 34 bases basis NNS cord-300061-l2pfl776 204 35 should should MD cord-300061-l2pfl776 204 36 not not RB cord-300061-l2pfl776 204 37 be be VB cord-300061-l2pfl776 204 38 disregarded disregard VBN cord-300061-l2pfl776 204 39 only only RB cord-300061-l2pfl776 204 40 because because IN cord-300061-l2pfl776 204 41 their -PRON- PRP$ cord-300061-l2pfl776 204 42 variations variation NNS cord-300061-l2pfl776 204 43 can can MD cord-300061-l2pfl776 204 44 be be VB cord-300061-l2pfl776 204 45 less less JJR cord-300061-l2pfl776 204 46 than than IN cord-300061-l2pfl776 204 47 that that DT cord-300061-l2pfl776 204 48 of of IN cord-300061-l2pfl776 204 49 the the DT cord-300061-l2pfl776 204 50 GC GC NNP cord-300061-l2pfl776 204 51 content content NN cord-300061-l2pfl776 204 52 . . . cord-300061-l2pfl776 205 1 4 4 LS cord-300061-l2pfl776 205 2 . . . cord-300061-l2pfl776 206 1 Elhaik Elhaik NNP cord-300061-l2pfl776 206 2 , , , cord-300061-l2pfl776 206 3 Graur Graur NNP cord-300061-l2pfl776 206 4 and and CC cord-300061-l2pfl776 206 5 Josic Josic NNP cord-300061-l2pfl776 206 6 finally finally RB cord-300061-l2pfl776 206 7 concluded conclude VBD cord-300061-l2pfl776 206 8 that that IN cord-300061-l2pfl776 206 9 " " `` cord-300061-l2pfl776 206 10 the the DT cord-300061-l2pfl776 206 11 genome genome NN cord-300061-l2pfl776 206 12 order order NN cord-300061-l2pfl776 206 13 index index NN cord-300061-l2pfl776 206 14 is be VBZ cord-300061-l2pfl776 206 15 a a DT cord-300061-l2pfl776 206 16 misconceived misconceived JJ cord-300061-l2pfl776 206 17 mathematical mathematical JJ cord-300061-l2pfl776 206 18 tool tool NN cord-300061-l2pfl776 206 19 that that WDT cord-300061-l2pfl776 206 20 should should MD cord-300061-l2pfl776 206 21 not not RB cord-300061-l2pfl776 206 22 be be VB cord-300061-l2pfl776 206 23 used use VBN cord-300061-l2pfl776 206 24 in in IN cord-300061-l2pfl776 206 25 a a DT cord-300061-l2pfl776 206 26 meritorious meritorious JJ cord-300061-l2pfl776 206 27 sequence sequence NN cord-300061-l2pfl776 206 28 analyses analysis NNS cord-300061-l2pfl776 206 29 . . . cord-300061-l2pfl776 207 1 " " `` cord-300061-l2pfl776 207 2 This this DT cord-300061-l2pfl776 207 3 conclusion conclusion NN cord-300061-l2pfl776 207 4 is be VBZ cord-300061-l2pfl776 207 5 , , , cord-300061-l2pfl776 207 6 by by IN cord-300061-l2pfl776 207 7 itself -PRON- PRP cord-300061-l2pfl776 207 8 , , , cord-300061-l2pfl776 207 9 not not RB cord-300061-l2pfl776 207 10 consistent consistent JJ cord-300061-l2pfl776 207 11 . . . cord-300061-l2pfl776 208 1 The the DT cord-300061-l2pfl776 208 2 Shannon Shannon NNP cord-300061-l2pfl776 208 3 entropy entropy NN cord-300061-l2pfl776 208 4 is be VBZ cord-300061-l2pfl776 208 5 a a DT cord-300061-l2pfl776 208 6 well well RB cord-300061-l2pfl776 208 7 - - HYPH cord-300061-l2pfl776 208 8 established establish VBN cord-300061-l2pfl776 208 9 method method NN cord-300061-l2pfl776 208 10 that that WDT cord-300061-l2pfl776 208 11 has have VBZ cord-300061-l2pfl776 208 12 been be VBN cord-300061-l2pfl776 208 13 widely widely RB cord-300061-l2pfl776 208 14 used use VBN cord-300061-l2pfl776 208 15 in in IN cord-300061-l2pfl776 208 16 many many JJ cord-300061-l2pfl776 208 17 areas area NNS cord-300061-l2pfl776 208 18 . . . cord-300061-l2pfl776 209 1 Elhaik Elhaik NNP cord-300061-l2pfl776 209 2 et et NNP cord-300061-l2pfl776 209 3 al al NNP cord-300061-l2pfl776 209 4 . . . cord-300061-l2pfl776 210 1 on on IN cord-300061-l2pfl776 210 2 the the DT cord-300061-l2pfl776 210 3 one one CD cord-300061-l2pfl776 210 4 hand hand NN cord-300061-l2pfl776 210 5 claim claim NN cord-300061-l2pfl776 210 6 that that IN cord-300061-l2pfl776 210 7 S S NNP cord-300061-l2pfl776 210 8 is be VBZ cord-300061-l2pfl776 210 9 strictly strictly RB cord-300061-l2pfl776 210 10 equivalent equivalent JJ cord-300061-l2pfl776 210 11 to to IN cord-300061-l2pfl776 210 12 the the DT cord-300061-l2pfl776 210 13 Shannon Shannon NNP cord-300061-l2pfl776 210 14 entropy entropy NN cord-300061-l2pfl776 210 15 , , , cord-300061-l2pfl776 210 16 and and CC cord-300061-l2pfl776 210 17 on on IN cord-300061-l2pfl776 210 18 the the DT cord-300061-l2pfl776 210 19 other other JJ cord-300061-l2pfl776 210 20 hand hand NN cord-300061-l2pfl776 210 21 claim claim NN cord-300061-l2pfl776 210 22 that that IN cord-300061-l2pfl776 210 23 S S NNP cord-300061-l2pfl776 210 24 is be VBZ cord-300061-l2pfl776 210 25 a a DT cord-300061-l2pfl776 210 26 misconceived misconceived JJ cord-300061-l2pfl776 210 27 mathematical mathematical JJ cord-300061-l2pfl776 210 28 tool tool NN cord-300061-l2pfl776 210 29 ; ; : cord-300061-l2pfl776 210 30 then then RB cord-300061-l2pfl776 210 31 the the DT cord-300061-l2pfl776 210 32 next next JJ cord-300061-l2pfl776 210 33 logical logical JJ cord-300061-l2pfl776 210 34 conclusion conclusion NN cord-300061-l2pfl776 210 35 would would MD cord-300061-l2pfl776 210 36 be be VB cord-300061-l2pfl776 210 37 the the DT cord-300061-l2pfl776 210 38 Shannon Shannon NNP cord-300061-l2pfl776 210 39 entropy entropy NN cord-300061-l2pfl776 210 40 is be VBZ cord-300061-l2pfl776 210 41 a a DT cord-300061-l2pfl776 210 42 misconceived misconceived JJ cord-300061-l2pfl776 210 43 mathematical mathematical JJ cord-300061-l2pfl776 210 44 tool tool NN cord-300061-l2pfl776 210 45 , , , cord-300061-l2pfl776 210 46 which which WDT cord-300061-l2pfl776 210 47 is be VBZ cord-300061-l2pfl776 210 48 obviously obviously RB cord-300061-l2pfl776 210 49 against against IN cord-300061-l2pfl776 210 50 scientific scientific JJ cord-300061-l2pfl776 210 51 commonsense commonsense NN cord-300061-l2pfl776 210 52 . . . cord-300061-l2pfl776 211 1 In in IN cord-300061-l2pfl776 211 2 summary summary NN cord-300061-l2pfl776 211 3 , , , cord-300061-l2pfl776 211 4 Elhaik Elhaik NNP cord-300061-l2pfl776 211 5 , , , cord-300061-l2pfl776 211 6 Graur Graur NNP cord-300061-l2pfl776 211 7 and and CC cord-300061-l2pfl776 211 8 Josic Josic NNP cord-300061-l2pfl776 211 9 ( ( -LRB- cord-300061-l2pfl776 211 10 i i NN cord-300061-l2pfl776 211 11 ) ) -RRB- cord-300061-l2pfl776 211 12 confuse confuse VBP cord-300061-l2pfl776 211 13 the the DT cord-300061-l2pfl776 211 14 reduced reduce VBN cord-300061-l2pfl776 211 15 coordinate coordinate NN cord-300061-l2pfl776 211 16 system system NN cord-300061-l2pfl776 211 17 with with IN cord-300061-l2pfl776 211 18 the the DT cord-300061-l2pfl776 211 19 original original JJ cord-300061-l2pfl776 211 20 one one NN cord-300061-l2pfl776 211 21 , , , cord-300061-l2pfl776 211 22 and and CC cord-300061-l2pfl776 211 23 consequently consequently RB cord-300061-l2pfl776 211 24 , , , cord-300061-l2pfl776 211 25 mistakenly mistakenly RB cord-300061-l2pfl776 211 26 neglected neglect VBD cord-300061-l2pfl776 211 27 the the DT cord-300061-l2pfl776 211 28 parameter parameter NN cord-300061-l2pfl776 211 29 4 4 CD cord-300061-l2pfl776 211 30 3 3 CD cord-300061-l2pfl776 211 31 / / SYM cord-300061-l2pfl776 211 32 when when WRB cord-300061-l2pfl776 211 33 calculating calculate VBG cord-300061-l2pfl776 211 34 the the DT cord-300061-l2pfl776 211 35 radius radius NN cord-300061-l2pfl776 211 36 of of IN cord-300061-l2pfl776 211 37 the the DT cord-300061-l2pfl776 211 38 inscribed inscribe VBN cord-300061-l2pfl776 211 39 sphere sphere NN cord-300061-l2pfl776 211 40 . . . cord-300061-l2pfl776 212 1 ( ( -LRB- cord-300061-l2pfl776 212 2 ii ii NN cord-300061-l2pfl776 212 3 ) ) -RRB- cord-300061-l2pfl776 213 1 The the DT cord-300061-l2pfl776 213 2 exponential exponential JJ cord-300061-l2pfl776 213 3 distribution distribution NN cord-300061-l2pfl776 213 4 of of IN cord-300061-l2pfl776 213 5 S S NNP cord-300061-l2pfl776 213 6 is be VBZ cord-300061-l2pfl776 213 7 a a DT cord-300061-l2pfl776 213 8 restatement restatement NN cord-300061-l2pfl776 213 9 of of IN cord-300061-l2pfl776 213 10 our -PRON- PRP$ cord-300061-l2pfl776 213 11 previous previous JJ cord-300061-l2pfl776 213 12 conclusion conclusion NN cord-300061-l2pfl776 213 13 , , , cord-300061-l2pfl776 213 14 and and CC cord-300061-l2pfl776 213 15 the the DT cord-300061-l2pfl776 213 16 range range NN cord-300061-l2pfl776 213 17 of of IN cord-300061-l2pfl776 213 18 ( ( -LRB- cord-300061-l2pfl776 213 19 0.25 0.25 CD cord-300061-l2pfl776 213 20 -0.33 -0.33 CD cord-300061-l2pfl776 213 21 ) ) -RRB- cord-300061-l2pfl776 213 22 only only RB cord-300061-l2pfl776 213 23 paraphrases paraphrase VBZ cord-300061-l2pfl776 213 24 the the DT cord-300061-l2pfl776 213 25 previously previously RB cord-300061-l2pfl776 213 26 suggested suggest VBN cord-300061-l2pfl776 213 27 S S NNP cord-300061-l2pfl776 213 28 range range NN cord-300061-l2pfl776 213 29 ( ( -LRB- cord-300061-l2pfl776 213 30 0.25 0.25 CD cord-300061-l2pfl776 213 31 -1/3 -1/3 NN cord-300061-l2pfl776 213 32 ) ) -RRB- cord-300061-l2pfl776 213 33 . . . cord-300061-l2pfl776 214 1 ( ( -LRB- cord-300061-l2pfl776 214 2 iii iii NN cord-300061-l2pfl776 214 3 ) ) -RRB- cord-300061-l2pfl776 215 1 Elhaik Elhaik NNP cord-300061-l2pfl776 215 2 et et NNP cord-300061-l2pfl776 215 3 al al NNP cord-300061-l2pfl776 215 4 . . . cord-300061-l2pfl776 216 1 incorrectly incorrectly RB cord-300061-l2pfl776 216 2 disregard disregard JJ cord-300061-l2pfl776 216 3 deviations deviation NNS cord-300061-l2pfl776 216 4 from from IN cord-300061-l2pfl776 216 5 PR2 PR2 NNP cord-300061-l2pfl776 216 6 by by IN cord-300061-l2pfl776 216 7 treating treat VBG cord-300061-l2pfl776 216 8 the the DT cord-300061-l2pfl776 216 9 deviations deviation NNS cord-300061-l2pfl776 216 10 as as IN cord-300061-l2pfl776 216 11 0 0 CD cord-300061-l2pfl776 216 12 altogether altogether RB cord-300061-l2pfl776 216 13 , , , cord-300061-l2pfl776 216 14 reduce reduce VB cord-300061-l2pfl776 216 15 S S NNP cord-300061-l2pfl776 216 16 and and CC cord-300061-l2pfl776 216 17 H H NNP cord-300061-l2pfl776 216 18 , , , cord-300061-l2pfl776 216 19 both both DT cord-300061-l2pfl776 216 20 having have VBG cord-300061-l2pfl776 216 21 4 4 CD cord-300061-l2pfl776 216 22 variables variable NNS cord-300061-l2pfl776 216 23 , , , cord-300061-l2pfl776 216 24 a a NN cord-300061-l2pfl776 216 25 , , , cord-300061-l2pfl776 216 26 c c NNP cord-300061-l2pfl776 216 27 , , , cord-300061-l2pfl776 216 28 g g NNP cord-300061-l2pfl776 216 29 and and CC cord-300061-l2pfl776 216 30 t t NNP cord-300061-l2pfl776 216 31 , , , cord-300061-l2pfl776 216 32 into into IN cord-300061-l2pfl776 216 33 functions function NNS cord-300061-l2pfl776 216 34 of of IN cord-300061-l2pfl776 216 35 one one CD cord-300061-l2pfl776 216 36 single single JJ cord-300061-l2pfl776 216 37 variable variable NN cord-300061-l2pfl776 216 38 , , , cord-300061-l2pfl776 216 39 a a DT cord-300061-l2pfl776 216 40 only only RB cord-300061-l2pfl776 216 41 , , , cord-300061-l2pfl776 216 42 and and CC cord-300061-l2pfl776 216 43 apply apply VB cord-300061-l2pfl776 216 44 this this DT cord-300061-l2pfl776 216 45 treatment treatment NN cord-300061-l2pfl776 216 46 to to IN cord-300061-l2pfl776 216 47 all all DT cord-300061-l2pfl776 216 48 DNA dna NN cord-300061-l2pfl776 216 49 sequences sequence NNS cord-300061-l2pfl776 216 50 as as IN cord-300061-l2pfl776 216 51 the the DT cord-300061-l2pfl776 216 52 basis basis NN cord-300061-l2pfl776 216 53 of of IN cord-300061-l2pfl776 216 54 their -PRON- PRP$ cord-300061-l2pfl776 216 55 " " `` cord-300061-l2pfl776 216 56 demonstration demonstration NN cord-300061-l2pfl776 216 57 " " '' cord-300061-l2pfl776 216 58 , , , cord-300061-l2pfl776 216 59 which which WDT cord-300061-l2pfl776 216 60 is be VBZ cord-300061-l2pfl776 216 61 therefore therefore RB cord-300061-l2pfl776 216 62 invalid invalid JJ cord-300061-l2pfl776 216 63 . . . cord-300061-l2pfl776 217 1 Importantly importantly RB cord-300061-l2pfl776 217 2 , , , cord-300061-l2pfl776 217 3 they -PRON- PRP cord-300061-l2pfl776 217 4 confuse confuse VBP cord-300061-l2pfl776 217 5 numeral numeral JJ cord-300061-l2pfl776 217 6 smallness smallness NN cord-300061-l2pfl776 217 7 with with IN cord-300061-l2pfl776 217 8 biological biological JJ cord-300061-l2pfl776 217 9 insignificance insignificance NN cord-300061-l2pfl776 217 10 , , , cord-300061-l2pfl776 217 11 and and CC cord-300061-l2pfl776 217 12 disregard disregard VB cord-300061-l2pfl776 217 13 the the DT cord-300061-l2pfl776 217 14 distributions distribution NNS cord-300061-l2pfl776 217 15 of of IN cord-300061-l2pfl776 217 16 purine purine NN cord-300061-l2pfl776 217 17 / / SYM cord-300061-l2pfl776 217 18 pyrimidine pyrimidine NN cord-300061-l2pfl776 217 19 and and CC cord-300061-l2pfl776 217 20 amino amino NNS cord-300061-l2pfl776 217 21 / / SYM cord-300061-l2pfl776 217 22 keto keto NNP cord-300061-l2pfl776 217 23 bases basis NNS cord-300061-l2pfl776 217 24 , , , cord-300061-l2pfl776 217 25 the the DT cord-300061-l2pfl776 217 26 variations variation NNS cord-300061-l2pfl776 217 27 of of IN cord-300061-l2pfl776 217 28 which which WDT cord-300061-l2pfl776 217 29 , , , cord-300061-l2pfl776 217 30 although although IN cord-300061-l2pfl776 217 31 sometimes sometimes RB cord-300061-l2pfl776 217 32 less less JJR cord-300061-l2pfl776 217 33 than than IN cord-300061-l2pfl776 217 34 that that DT cord-300061-l2pfl776 217 35 of of IN cord-300061-l2pfl776 217 36 GC GC NNP cord-300061-l2pfl776 217 37 content content NN cord-300061-l2pfl776 217 38 , , , cord-300061-l2pfl776 217 39 contain contain VBP cord-300061-l2pfl776 217 40 rich rich JJ cord-300061-l2pfl776 217 41 information information NN cord-300061-l2pfl776 217 42 that that WDT cord-300061-l2pfl776 217 43 is be VBZ cord-300061-l2pfl776 217 44 important important JJ cord-300061-l2pfl776 217 45 and and CC cord-300061-l2pfl776 217 46 useful useful JJ cord-300061-l2pfl776 217 47 . . . cord-300061-l2pfl776 218 1 Therefore therefore RB cord-300061-l2pfl776 218 2 , , , cord-300061-l2pfl776 218 3 the the DT cord-300061-l2pfl776 218 4 criticisms criticism NNS cord-300061-l2pfl776 218 5 of of IN cord-300061-l2pfl776 218 6 Elhaik Elhaik NNP cord-300061-l2pfl776 218 7 , , , cord-300061-l2pfl776 218 8 Graur Graur NNP cord-300061-l2pfl776 218 9 and and CC cord-300061-l2pfl776 218 10 Josic Josic NNP cord-300061-l2pfl776 218 11 are be VBP cord-300061-l2pfl776 218 12 wrong wrong JJ cord-300061-l2pfl776 218 13 . . . cord-300061-l2pfl776 219 1 The the DT cord-300061-l2pfl776 219 2 same same JJ cord-300061-l2pfl776 219 3 235 235 CD cord-300061-l2pfl776 219 4 bacterial bacterial JJ cord-300061-l2pfl776 219 5 genomes genome NNS cord-300061-l2pfl776 219 6 ( ( -LRB- cord-300061-l2pfl776 219 7 based base VBN cord-300061-l2pfl776 219 8 on on IN cord-300061-l2pfl776 219 9 genome genome NN cord-300061-l2pfl776 219 10 names name NNS cord-300061-l2pfl776 219 11 ) ) -RRB- cord-300061-l2pfl776 219 12 that that WDT cord-300061-l2pfl776 219 13 were be VBD cord-300061-l2pfl776 219 14 used use VBN cord-300061-l2pfl776 219 15 by by IN cord-300061-l2pfl776 219 16 Elhaik Elhaik NNP cord-300061-l2pfl776 219 17 et et NNP cord-300061-l2pfl776 219 18 al al NNP cord-300061-l2pfl776 219 19 . . . cord-300061-l2pfl776 220 1 in in IN cord-300061-l2pfl776 220 2 [ [ -LRB- cord-300061-l2pfl776 220 3 5 5 CD cord-300061-l2pfl776 220 4 ] ] -RRB- cord-300061-l2pfl776 220 5 were be VBD cord-300061-l2pfl776 220 6 analyzed analyze VBN cord-300061-l2pfl776 220 7 . . . cord-300061-l2pfl776 221 1 The the DT cord-300061-l2pfl776 221 2 data datum NNS cord-300061-l2pfl776 221 3 in in IN cord-300061-l2pfl776 221 4 Table Table NNP cord-300061-l2pfl776 221 5 S1 S1 NNP cord-300061-l2pfl776 221 6 in in IN cord-300061-l2pfl776 221 7 ref ref NN cord-300061-l2pfl776 221 8 . . . cord-300061-l2pfl776 222 1 [ [ -LRB- cord-300061-l2pfl776 222 2 5 5 LS cord-300061-l2pfl776 222 3 ] ] -RRB- cord-300061-l2pfl776 222 4 contain contain VBP cord-300061-l2pfl776 222 5 numerous numerous JJ cord-300061-l2pfl776 222 6 mistakes mistake NNS cord-300061-l2pfl776 222 7 . . . cord-300061-l2pfl776 223 1 The the DT cord-300061-l2pfl776 223 2 Table Table NNP cord-300061-l2pfl776 223 3 S1 s1 NN cord-300061-l2pfl776 223 4 contains contain VBZ cord-300061-l2pfl776 223 5 4 4 CD cord-300061-l2pfl776 223 6 columns column NNS cord-300061-l2pfl776 223 7 , , , cord-300061-l2pfl776 223 8 genome genome NN cord-300061-l2pfl776 223 9 name name NN cord-300061-l2pfl776 223 10 , , , cord-300061-l2pfl776 223 11 size size NN cord-300061-l2pfl776 223 12 , , , cord-300061-l2pfl776 223 13 GC GC NNP cord-300061-l2pfl776 223 14 content content NN cord-300061-l2pfl776 223 15 and and CC cord-300061-l2pfl776 223 16 ID ID NNP cord-300061-l2pfl776 223 17 . . . cord-300061-l2pfl776 224 1 Eighteen eighteen CD cord-300061-l2pfl776 224 2 IDs id NNS cord-300061-l2pfl776 224 3 correspond correspond VBP cord-300061-l2pfl776 224 4 to to IN cord-300061-l2pfl776 224 5 plasmids plasmid NNS cord-300061-l2pfl776 224 6 , , , cord-300061-l2pfl776 224 7 not not RB cord-300061-l2pfl776 224 8 genomes genome NNS cord-300061-l2pfl776 224 9 . . . cord-300061-l2pfl776 225 1 These these DT cord-300061-l2pfl776 225 2 IDs id NNS cord-300061-l2pfl776 225 3 are be VBP cord-300061-l2pfl776 225 4 : : : cord-300061-l2pfl776 225 5 NC_007410 NC_007410 NNP cord-300061-l2pfl776 225 6 , , , cord-300061-l2pfl776 225 7 NC_006873 nc_006873 UH cord-300061-l2pfl776 225 8 , , , cord-300061-l2pfl776 225 9 NC_004943 NC_004943 NNP cord-300061-l2pfl776 225 10 , , , cord-300061-l2pfl776 225 11 NC_003080 NC_003080 NNP cord-300061-l2pfl776 225 12 , , , cord-300061-l2pfl776 225 13 NC_007414 NC_007414 NNP cord-300061-l2pfl776 225 14 , , , cord-300061-l2pfl776 225 15 NC_007515 NC_007515 NNP cord-300061-l2pfl776 225 16 , , , cord-300061-l2pfl776 225 17 NC_007801 NC_007801 NNP cord-300061-l2pfl776 225 18 , , , cord-300061-l2pfl776 225 19 NC_007483 NC_007483 NNP cord-300061-l2pfl776 225 20 , , , cord-300061-l2pfl776 225 21 NC_007274 NC_007274 NNP cord-300061-l2pfl776 225 22 , , , cord-300061-l2pfl776 225 23 NC_007336 NC_007336 NNP cord-300061-l2pfl776 225 24 , , , cord-300061-l2pfl776 225 25 NC_007901 NC_007901 NNP cord-300061-l2pfl776 225 26 , , , cord-300061-l2pfl776 225 27 NC_007641 NC_007641 NNP cord-300061-l2pfl776 225 28 , , , cord-300061-l2pfl776 225 29 NC_006855 NC_006855 NNP cord-300061-l2pfl776 225 30 , , , cord-300061-l2pfl776 225 31 NC_007608 NC_007608 NNP cord-300061-l2pfl776 225 32 , , , cord-300061-l2pfl776 225 33 NC_005951 NC_005951 NNP cord-300061-l2pfl776 225 34 , , , cord-300061-l2pfl776 225 35 NC_006663 nc_006663 UH cord-300061-l2pfl776 225 36 , , , cord-300061-l2pfl776 225 37 NC_005229 NC_005229 NNP cord-300061-l2pfl776 225 38 and and CC cord-300061-l2pfl776 225 39 NC_004554 NC_004554 NNP cord-300061-l2pfl776 225 40 . . . cord-300061-l2pfl776 226 1 Calculation calculation NN cord-300061-l2pfl776 226 2 of of IN cord-300061-l2pfl776 226 3 genome genome NN cord-300061-l2pfl776 226 4 length length NN cord-300061-l2pfl776 226 5 and and CC cord-300061-l2pfl776 226 6 GC GC NNP cord-300061-l2pfl776 226 7 content content NN cord-300061-l2pfl776 226 8 is be VBZ cord-300061-l2pfl776 226 9 incorrect incorrect JJ cord-300061-l2pfl776 226 10 for for IN cord-300061-l2pfl776 226 11 many many JJ cord-300061-l2pfl776 226 12 genomes genome NNS cord-300061-l2pfl776 226 13 . . . cord-300061-l2pfl776 227 1 For for IN cord-300061-l2pfl776 227 2 instance instance NN cord-300061-l2pfl776 227 3 , , , cord-300061-l2pfl776 227 4 the the DT cord-300061-l2pfl776 227 5 calculated calculate VBN cord-300061-l2pfl776 227 6 GC GC NNP cord-300061-l2pfl776 227 7 content content NN cord-300061-l2pfl776 227 8 for for IN cord-300061-l2pfl776 227 9 B. B. NNP cord-300061-l2pfl776 227 10 fragilis fragilis JJ cord-300061-l2pfl776 227 11 YCH46 YCH46 NNP cord-300061-l2pfl776 227 12 ( ( -LRB- cord-300061-l2pfl776 227 13 NC_006347 NC_006347 NNP cord-300061-l2pfl776 227 14 ) ) -RRB- cord-300061-l2pfl776 227 15 was be VBD cord-300061-l2pfl776 227 16 33.50 33.50 CD cord-300061-l2pfl776 227 17 % % NN cord-300061-l2pfl776 227 18 [ [ -LRB- cord-300061-l2pfl776 227 19 5 5 CD cord-300061-l2pfl776 227 20 ] ] -RRB- cord-300061-l2pfl776 227 21 , , , cord-300061-l2pfl776 227 22 while while IN cord-300061-l2pfl776 227 23 the the DT cord-300061-l2pfl776 227 24 correct correct JJ cord-300061-l2pfl776 227 25 number number NN cord-300061-l2pfl776 227 26 is be VBZ cord-300061-l2pfl776 227 27 43.27 43.27 CD cord-300061-l2pfl776 227 28 % % NN cord-300061-l2pfl776 227 29 . . . cord-300061-l2pfl776 228 1 The the DT cord-300061-l2pfl776 228 2 calculated calculate VBN cord-300061-l2pfl776 228 3 GC GC NNP cord-300061-l2pfl776 228 4 content content NN cord-300061-l2pfl776 228 5 for for IN cord-300061-l2pfl776 228 6 C. C. NNP cord-300061-l2pfl776 228 7 acetobutylicum acetobutylicum NNP cord-300061-l2pfl776 228 8 ATCC ATCC NNP cord-300061-l2pfl776 228 9 824 824 CD cord-300061-l2pfl776 229 1 ( ( -LRB- cord-300061-l2pfl776 229 2 NC_003030 NC_003030 NNP cord-300061-l2pfl776 229 3 ) ) -RRB- cord-300061-l2pfl776 229 4 was be VBD cord-300061-l2pfl776 229 5 37.00 37.00 CD cord-300061-l2pfl776 229 6 % % NN cord-300061-l2pfl776 229 7 [ [ -LRB- cord-300061-l2pfl776 229 8 5 5 CD cord-300061-l2pfl776 229 9 ] ] -RRB- cord-300061-l2pfl776 229 10 , , , cord-300061-l2pfl776 229 11 while while IN cord-300061-l2pfl776 229 12 the the DT cord-300061-l2pfl776 229 13 correct correct JJ cord-300061-l2pfl776 229 14 number number NN cord-300061-l2pfl776 229 15 is be VBZ cord-300061-l2pfl776 229 16 30.93 30.93 CD cord-300061-l2pfl776 229 17 % % NN cord-300061-l2pfl776 229 18 . . . cord-300061-l2pfl776 230 1 This this DT cord-300061-l2pfl776 230 2 manuscript manuscript NN cord-300061-l2pfl776 230 3 , , , cord-300061-l2pfl776 230 4 seems seem VBZ cord-300061-l2pfl776 230 5 to to TO cord-300061-l2pfl776 230 6 be be VB cord-300061-l2pfl776 230 7 the the DT cord-300061-l2pfl776 230 8 latest late JJS cord-300061-l2pfl776 230 9 shot shot NN cord-300061-l2pfl776 230 10 in in IN cord-300061-l2pfl776 230 11 an an DT cord-300061-l2pfl776 230 12 ongoing ongoing JJ cord-300061-l2pfl776 230 13 dispute dispute NN cord-300061-l2pfl776 230 14 between between IN cord-300061-l2pfl776 230 15 this this DT cord-300061-l2pfl776 230 16 author author NN cord-300061-l2pfl776 230 17 and and CC cord-300061-l2pfl776 230 18 Elhaik Elhaik NNP cord-300061-l2pfl776 230 19 et et NNP cord-300061-l2pfl776 230 20 al al NNP cord-300061-l2pfl776 230 21 . . . cord-300061-l2pfl776 231 1 regarding regard VBG cord-300061-l2pfl776 231 2 the the DT cord-300061-l2pfl776 231 3 usefulness usefulness NN cord-300061-l2pfl776 231 4 of of IN cord-300061-l2pfl776 231 5 certain certain JJ cord-300061-l2pfl776 231 6 statistics statistic NNS cord-300061-l2pfl776 231 7 for for IN cord-300061-l2pfl776 231 8 analyzing analyze VBG cord-300061-l2pfl776 231 9 base base NN cord-300061-l2pfl776 231 10 composition composition NN cord-300061-l2pfl776 231 11 of of IN cord-300061-l2pfl776 231 12 DNA DNA NNP cord-300061-l2pfl776 231 13 . . . cord-300061-l2pfl776 232 1 After after IN cord-300061-l2pfl776 232 2 looking look VBG cord-300061-l2pfl776 232 3 at at IN cord-300061-l2pfl776 232 4 this this DT cord-300061-l2pfl776 232 5 manuscript manuscript NN cord-300061-l2pfl776 232 6 and and CC cord-300061-l2pfl776 232 7 the the DT cord-300061-l2pfl776 232 8 paper paper NN cord-300061-l2pfl776 232 9 that that IN cord-300061-l2pfl776 232 10 it -PRON- PRP cord-300061-l2pfl776 232 11 is be VBZ cord-300061-l2pfl776 232 12 a a DT cord-300061-l2pfl776 232 13 rebuttal rebuttal NN cord-300061-l2pfl776 232 14 to to IN cord-300061-l2pfl776 232 15 , , , cord-300061-l2pfl776 232 16 I -PRON- PRP cord-300061-l2pfl776 232 17 must must MD cord-300061-l2pfl776 232 18 say say VB cord-300061-l2pfl776 232 19 that that IN cord-300061-l2pfl776 232 20 I -PRON- PRP cord-300061-l2pfl776 232 21 am be VBP cord-300061-l2pfl776 232 22 amazed amazed JJ cord-300061-l2pfl776 232 23 that that IN cord-300061-l2pfl776 232 24 so so RB cord-300061-l2pfl776 232 25 much much JJ cord-300061-l2pfl776 232 26 debate debate NN cord-300061-l2pfl776 232 27 can can MD cord-300061-l2pfl776 232 28 arise arise VB cord-300061-l2pfl776 232 29 over over IN cord-300061-l2pfl776 232 30 issues issue NNS cord-300061-l2pfl776 232 31 that that WDT cord-300061-l2pfl776 232 32 are be VBP cord-300061-l2pfl776 232 33 essentially essentially RB cord-300061-l2pfl776 232 34 very very RB cord-300061-l2pfl776 232 35 basic basic JJ cord-300061-l2pfl776 232 36 ( ( -LRB- cord-300061-l2pfl776 232 37 i.e. i.e. FW cord-300061-l2pfl776 232 38 how how WRB cord-300061-l2pfl776 232 39 to to TO cord-300061-l2pfl776 232 40 summarize summarize VB cord-300061-l2pfl776 232 41 base base NN cord-300061-l2pfl776 232 42 composition composition NN cord-300061-l2pfl776 232 43 in in IN cord-300061-l2pfl776 232 44 one one CD cord-300061-l2pfl776 232 45 or or CC cord-300061-l2pfl776 232 46 a a DT cord-300061-l2pfl776 232 47 few few JJ cord-300061-l2pfl776 232 48 statistics statistic NNS cord-300061-l2pfl776 232 49 ) ) -RRB- cord-300061-l2pfl776 232 50 and and CC cord-300061-l2pfl776 232 51 I -PRON- PRP cord-300061-l2pfl776 232 52 am be VBP cord-300061-l2pfl776 232 53 wondering wonder VBG cord-300061-l2pfl776 232 54 how how WRB cord-300061-l2pfl776 232 55 useful useful JJ cord-300061-l2pfl776 232 56 these these DT cord-300061-l2pfl776 232 57 kinds kind NNS cord-300061-l2pfl776 232 58 of of IN cord-300061-l2pfl776 232 59 exchanges exchange NNS cord-300061-l2pfl776 232 60 are be VBP cord-300061-l2pfl776 232 61 for for IN cord-300061-l2pfl776 232 62 general general JJ cord-300061-l2pfl776 232 63 readers reader NNS cord-300061-l2pfl776 232 64 . . . cord-300061-l2pfl776 233 1 Much much JJ cord-300061-l2pfl776 233 2 of of IN cord-300061-l2pfl776 233 3 the the DT cord-300061-l2pfl776 233 4 discussion discussion NN cord-300061-l2pfl776 233 5 centers center NNS cord-300061-l2pfl776 233 6 around around IN cord-300061-l2pfl776 233 7 the the DT cord-300061-l2pfl776 233 8 DNAsequence dnasequence NN cord-300061-l2pfl776 233 9 statistic statistic NN cord-300061-l2pfl776 233 10 S S NNP cord-300061-l2pfl776 233 11 , , , cord-300061-l2pfl776 233 12 which which WDT cord-300061-l2pfl776 233 13 is be VBZ cord-300061-l2pfl776 233 14 defined define VBN cord-300061-l2pfl776 233 15 as as IN cord-300061-l2pfl776 233 16 the the DT cord-300061-l2pfl776 233 17 sum sum NN cord-300061-l2pfl776 233 18 of of IN cord-300061-l2pfl776 233 19 the the DT cord-300061-l2pfl776 233 20 square square NN cord-300061-l2pfl776 233 21 - - HYPH cord-300061-l2pfl776 233 22 frequencies frequency NNS cord-300061-l2pfl776 233 23 of of IN cord-300061-l2pfl776 233 24 the the DT cord-300061-l2pfl776 233 25 letters letter NNS cord-300061-l2pfl776 233 26 : : : cord-300061-l2pfl776 233 27 S s NN cord-300061-l2pfl776 233 28 = = NFP cord-300061-l2pfl776 234 1 ( ( -LRB- cord-300061-l2pfl776 234 2 f_a)^2 f_a)^2 NNP cord-300061-l2pfl776 234 3 , , , cord-300061-l2pfl776 234 4 + + CC cord-300061-l2pfl776 235 1 ( ( -LRB- cord-300061-l2pfl776 235 2 f_c)^2 f_c)^2 NNP cord-300061-l2pfl776 235 3 + + CC cord-300061-l2pfl776 236 1 ( ( -LRB- cord-300061-l2pfl776 236 2 f_g)^2 f_g)^2 NNP cord-300061-l2pfl776 236 3 + + CC cord-300061-l2pfl776 236 4 ( ( -LRB- cord-300061-l2pfl776 236 5 f_t)^2 f_t)^2 NNP cord-300061-l2pfl776 236 6 where where WRB cord-300061-l2pfl776 236 7 f_a f_a NNP cord-300061-l2pfl776 236 8 , , , cord-300061-l2pfl776 236 9 f_c f_c NN cord-300061-l2pfl776 236 10 , , , cord-300061-l2pfl776 236 11 f_g f_g NN cord-300061-l2pfl776 236 12 , , , cord-300061-l2pfl776 236 13 and and CC cord-300061-l2pfl776 236 14 f_t f_t NNP cord-300061-l2pfl776 236 15 are be VBP cord-300061-l2pfl776 236 16 the the DT cord-300061-l2pfl776 236 17 base base NN cord-300061-l2pfl776 236 18 frequencies frequency NNS cord-300061-l2pfl776 236 19 . . . cord-300061-l2pfl776 237 1 Clearly clearly RB cord-300061-l2pfl776 237 2 , , , cord-300061-l2pfl776 237 3 since since IN cord-300061-l2pfl776 237 4 f_a f_a CD cord-300061-l2pfl776 237 5 + + SYM cord-300061-l2pfl776 237 6 f_c f_c NN cord-300061-l2pfl776 237 7 + + SYM cord-300061-l2pfl776 237 8 f_g f_g NN cord-300061-l2pfl776 237 9 + + SYM cord-300061-l2pfl776 237 10 f_t f_t NN cord-300061-l2pfl776 237 11 = = SYM cord-300061-l2pfl776 237 12 1 1 CD cord-300061-l2pfl776 237 13 , , , cord-300061-l2pfl776 237 14 we -PRON- PRP cord-300061-l2pfl776 237 15 necessarily necessarily RB cord-300061-l2pfl776 237 16 have have VBP cord-300061-l2pfl776 237 17 that that DT cord-300061-l2pfl776 237 18 S S NNP cord-300061-l2pfl776 237 19 lies lie VBZ cord-300061-l2pfl776 237 20 in in IN cord-300061-l2pfl776 237 21 the the DT cord-300061-l2pfl776 237 22 range range NN cord-300061-l2pfl776 237 23 [ [ -LRB- cord-300061-l2pfl776 237 24 0 0 NFP cord-300061-l2pfl776 237 25 . . . cord-300061-l2pfl776 238 1 25 25 CD cord-300061-l2pfl776 238 2 , , , cord-300061-l2pfl776 238 3 1 1 CD cord-300061-l2pfl776 238 4 ] ] -RRB- cord-300061-l2pfl776 238 5 . . . cord-300061-l2pfl776 239 1 Both both CC cord-300061-l2pfl776 239 2 this this DT cord-300061-l2pfl776 239 3 author author NN cord-300061-l2pfl776 239 4 and and CC cord-300061-l2pfl776 239 5 Elhaik Elhaik NNP cord-300061-l2pfl776 239 6 et et NNP cord-300061-l2pfl776 239 7 al al NNP cord-300061-l2pfl776 239 8 . . . cord-300061-l2pfl776 239 9 seem seem VBP cord-300061-l2pfl776 239 10 to to TO cord-300061-l2pfl776 239 11 agree agree VB cord-300061-l2pfl776 239 12 that that IN cord-300061-l2pfl776 239 13 , , , cord-300061-l2pfl776 239 14 for for IN cord-300061-l2pfl776 239 15 a a DT cord-300061-l2pfl776 239 16 large large JJ cord-300061-l2pfl776 239 17 collection collection NN cord-300061-l2pfl776 239 18 of of IN cord-300061-l2pfl776 239 19 bacterial bacterial JJ cord-300061-l2pfl776 239 20 genomes genome NNS cord-300061-l2pfl776 239 21 , , , cord-300061-l2pfl776 239 22 we -PRON- PRP cord-300061-l2pfl776 239 23 find find VBP cord-300061-l2pfl776 239 24 S s NN cord-300061-l2pfl776 239 25 < < XX cord-300061-l2pfl776 239 26 1/3 1/3 XX cord-300061-l2pfl776 240 1 but but CC cord-300061-l2pfl776 240 2 there there EX cord-300061-l2pfl776 240 3 is be VBZ cord-300061-l2pfl776 240 4 disagreement disagreement NN cord-300061-l2pfl776 240 5 about about IN cord-300061-l2pfl776 240 6 how how WRB cord-300061-l2pfl776 240 7 ' ' `` cord-300061-l2pfl776 240 8 surprising surprising JJ cord-300061-l2pfl776 240 9 ' ' '' cord-300061-l2pfl776 240 10 this this DT cord-300061-l2pfl776 240 11 is be VBZ cord-300061-l2pfl776 240 12 and and CC cord-300061-l2pfl776 240 13 what what WDT cord-300061-l2pfl776 240 14 kind kind NN cord-300061-l2pfl776 240 15 of of IN cord-300061-l2pfl776 240 16 constraint constraint NN cord-300061-l2pfl776 240 17 that that WDT cord-300061-l2pfl776 240 18 this this DT cord-300061-l2pfl776 240 19 is be VBZ cord-300061-l2pfl776 240 20 indicative indicative JJ cord-300061-l2pfl776 240 21 of of IN cord-300061-l2pfl776 240 22 . . . cord-300061-l2pfl776 241 1 First first RB cord-300061-l2pfl776 241 2 of of IN cord-300061-l2pfl776 241 3 all all DT cord-300061-l2pfl776 241 4 , , , cord-300061-l2pfl776 241 5 it -PRON- PRP cord-300061-l2pfl776 241 6 is be VBZ cord-300061-l2pfl776 241 7 clear clear JJ cord-300061-l2pfl776 241 8 that that IN cord-300061-l2pfl776 241 9 for for IN cord-300061-l2pfl776 241 10 uniformly uniformly RB cord-300061-l2pfl776 241 11 random random JJ cord-300061-l2pfl776 241 12 sequences sequence NNS cord-300061-l2pfl776 241 13 the the DT cord-300061-l2pfl776 241 14 frequencies frequency NNS cord-300061-l2pfl776 241 15 f_x f_x NNP cord-300061-l2pfl776 241 16 will will MD cord-300061-l2pfl776 241 17 be be VB cord-300061-l2pfl776 241 18 close close JJ cord-300061-l2pfl776 241 19 to to IN cord-300061-l2pfl776 241 20 0.25 0.25 CD cord-300061-l2pfl776 242 1 and and CC cord-300061-l2pfl776 242 2 thus thus RB cord-300061-l2pfl776 242 3 S S NNP cord-300061-l2pfl776 242 4 will will MD cord-300061-l2pfl776 242 5 be be VB cord-300061-l2pfl776 242 6 close close JJ cord-300061-l2pfl776 242 7 to to IN cord-300061-l2pfl776 242 8 0.25 0.25 CD cord-300061-l2pfl776 242 9 as as IN cord-300061-l2pfl776 242 10 wll wll NN cord-300061-l2pfl776 242 11 . . . cord-300061-l2pfl776 243 1 Only only RB cord-300061-l2pfl776 243 2 for for IN cord-300061-l2pfl776 243 3 extremely extremely RB cord-300061-l2pfl776 243 4 biased biased JJ cord-300061-l2pfl776 243 5 base base NN cord-300061-l2pfl776 243 6 compositions composition NNS cord-300061-l2pfl776 243 7 would would MD cord-300061-l2pfl776 243 8 one one PRP cord-300061-l2pfl776 243 9 get get VB cord-300061-l2pfl776 243 10 values value NNS cord-300061-l2pfl776 243 11 of of IN cord-300061-l2pfl776 243 12 S S NNP cord-300061-l2pfl776 243 13 close close RB cord-300061-l2pfl776 243 14 to to IN cord-300061-l2pfl776 243 15 1 1 CD cord-300061-l2pfl776 243 16 and and CC cord-300061-l2pfl776 243 17 so so RB cord-300061-l2pfl776 243 18 , , , cord-300061-l2pfl776 243 19 in in IN cord-300061-l2pfl776 243 20 my -PRON- PRP$ cord-300061-l2pfl776 243 21 opinion opinion NN cord-300061-l2pfl776 243 22 , , , cord-300061-l2pfl776 243 23 it -PRON- PRP cord-300061-l2pfl776 243 24 is be VBZ cord-300061-l2pfl776 243 25 not not RB cord-300061-l2pfl776 243 26 ' ' `` cord-300061-l2pfl776 243 27 surprising surprising JJ cord-300061-l2pfl776 243 28 ' ' '' cord-300061-l2pfl776 243 29 at at RB cord-300061-l2pfl776 243 30 all all RB cord-300061-l2pfl776 243 31 that that WDT cord-300061-l2pfl776 243 32 there there RB cord-300061-l2pfl776 243 33 that that WDT cord-300061-l2pfl776 243 34 one one NN cord-300061-l2pfl776 243 35 does do VBZ cord-300061-l2pfl776 243 36 not not RB cord-300061-l2pfl776 243 37 find find VB cord-300061-l2pfl776 243 38 genomes genome NNS cord-300061-l2pfl776 243 39 with with IN cord-300061-l2pfl776 243 40 large large JJ cord-300061-l2pfl776 243 41 S s NN cord-300061-l2pfl776 243 42 values value NNS cord-300061-l2pfl776 243 43 . . . cord-300061-l2pfl776 244 1 One one PRP cord-300061-l2pfl776 244 2 might may MD cord-300061-l2pfl776 244 3 reasonably reasonably RB cord-300061-l2pfl776 244 4 argue argue VB cord-300061-l2pfl776 244 5 , , , cord-300061-l2pfl776 244 6 in in IN cord-300061-l2pfl776 244 7 my -PRON- PRP$ cord-300061-l2pfl776 244 8 opinion opinion NN cord-300061-l2pfl776 244 9 , , , cord-300061-l2pfl776 244 10 that that IN cord-300061-l2pfl776 244 11 the the DT cord-300061-l2pfl776 244 12 surprising surprising JJ cord-300061-l2pfl776 244 13 observation observation NN cord-300061-l2pfl776 244 14 is be VBZ cord-300061-l2pfl776 244 15 that that IN cord-300061-l2pfl776 244 16 one one PRP cord-300061-l2pfl776 244 17 gets get VBZ cord-300061-l2pfl776 244 18 S s NN cord-300061-l2pfl776 244 19 values value NNS cord-300061-l2pfl776 244 20 as as RB cord-300061-l2pfl776 244 21 HIGH high JJ cord-300061-l2pfl776 244 22 as as IN cord-300061-l2pfl776 244 23 0.33 0.33 CD cord-300061-l2pfl776 244 24 . . . cord-300061-l2pfl776 245 1 A a DT cord-300061-l2pfl776 245 2 second second JJ cord-300061-l2pfl776 245 3 point point NN cord-300061-l2pfl776 245 4 of of IN cord-300061-l2pfl776 245 5 contention contention NN cord-300061-l2pfl776 245 6 is be VBZ cord-300061-l2pfl776 245 7 whether whether IN cord-300061-l2pfl776 245 8 the the DT cord-300061-l2pfl776 245 9 S S NNP cord-300061-l2pfl776 245 10 statistic statistic NN cord-300061-l2pfl776 245 11 and and CC cord-300061-l2pfl776 245 12 the the DT cord-300061-l2pfl776 245 13 entropy entropy NN cord-300061-l2pfl776 245 14 H h NN cord-300061-l2pfl776 245 15 = = NN cord-300061-l2pfl776 245 16 -sum_x -sum_x : cord-300061-l2pfl776 245 17 f_x f_x CD cord-300061-l2pfl776 245 18 log(f_x log(f_x ADD cord-300061-l2pfl776 245 19 ) ) -RRB- cord-300061-l2pfl776 245 20 are be VBP cord-300061-l2pfl776 245 21 ' ' `` cord-300061-l2pfl776 245 22 equivalent equivalent JJ cord-300061-l2pfl776 245 23 ' ' '' cord-300061-l2pfl776 245 24 . . . cord-300061-l2pfl776 246 1 The the DT cord-300061-l2pfl776 246 2 dispute dispute NN cord-300061-l2pfl776 246 3 here here RB cord-300061-l2pfl776 246 4 seems seem VBZ cord-300061-l2pfl776 246 5 to to TO cord-300061-l2pfl776 246 6 mostly mostly RB cord-300061-l2pfl776 246 7 be be VB cord-300061-l2pfl776 246 8 of of IN cord-300061-l2pfl776 246 9 a a DT cord-300061-l2pfl776 246 10 semantic semantic JJ cord-300061-l2pfl776 246 11 nature nature NN cord-300061-l2pfl776 246 12 , , , cord-300061-l2pfl776 246 13 i.e. i.e. FW cord-300061-l2pfl776 246 14 regarding regard VBG cord-300061-l2pfl776 246 15 the the DT cord-300061-l2pfl776 246 16 meaning meaning NN cord-300061-l2pfl776 246 17 of of IN cord-300061-l2pfl776 246 18 the the DT cord-300061-l2pfl776 246 19 word word NN cord-300061-l2pfl776 246 20 ' ' `` cord-300061-l2pfl776 246 21 equivalent equivalent JJ cord-300061-l2pfl776 246 22 ' ' '' cord-300061-l2pfl776 246 23 . . . cord-300061-l2pfl776 247 1 I -PRON- PRP cord-300061-l2pfl776 247 2 can can MD cord-300061-l2pfl776 247 3 only only RB cord-300061-l2pfl776 247 4 see see VB cord-300061-l2pfl776 247 5 two two CD cord-300061-l2pfl776 247 6 relevant relevant JJ cord-300061-l2pfl776 247 7 points point NNS cord-300061-l2pfl776 247 8 : : : cord-300061-l2pfl776 247 9 1 1 LS cord-300061-l2pfl776 247 10 ) ) -RRB- cord-300061-l2pfl776 248 1 For for IN cord-300061-l2pfl776 248 2 large large JJ cord-300061-l2pfl776 248 3 DNA dna NN cord-300061-l2pfl776 248 4 sequences sequence NNS cord-300061-l2pfl776 248 5 ( ( -LRB- cord-300061-l2pfl776 248 6 like like IN cord-300061-l2pfl776 248 7 whole whole JJ cord-300061-l2pfl776 248 8 genomes genome NNS cord-300061-l2pfl776 248 9 ) ) -RRB- cord-300061-l2pfl776 248 10 it -PRON- PRP cord-300061-l2pfl776 248 11 is be VBZ cord-300061-l2pfl776 248 12 observed observe VBN cord-300061-l2pfl776 248 13 that that IN cord-300061-l2pfl776 248 14 there there EX cord-300061-l2pfl776 248 15 is be VBZ cord-300061-l2pfl776 248 16 an an DT cord-300061-l2pfl776 248 17 approximate approximate JJ cord-300061-l2pfl776 248 18 symmetry symmetry NN cord-300061-l2pfl776 248 19 between between IN cord-300061-l2pfl776 248 20 the the DT cord-300061-l2pfl776 248 21 two two CD cord-300061-l2pfl776 248 22 DNA dna NN cord-300061-l2pfl776 248 23 strands strand NNS cord-300061-l2pfl776 248 24 , , , cord-300061-l2pfl776 248 25 i.e. i.e. FW cord-300061-l2pfl776 248 26 the the DT cord-300061-l2pfl776 248 27 base base NN cord-300061-l2pfl776 248 28 composition composition NN cord-300061-l2pfl776 248 29 in in IN cord-300061-l2pfl776 248 30 one one CD cord-300061-l2pfl776 248 31 strand strand NN cord-300061-l2pfl776 248 32 is be VBZ cord-300061-l2pfl776 248 33 not not RB cord-300061-l2pfl776 248 34 significantly significantly RB cord-300061-l2pfl776 248 35 different different JJ cord-300061-l2pfl776 248 36 from from IN cord-300061-l2pfl776 248 37 the the DT cord-300061-l2pfl776 248 38 base base NN cord-300061-l2pfl776 248 39 composition composition NN cord-300061-l2pfl776 248 40 in in IN cord-300061-l2pfl776 248 41 the the DT cord-300061-l2pfl776 248 42 other other JJ cord-300061-l2pfl776 248 43 strand strand NN cord-300061-l2pfl776 248 44 . . . cord-300061-l2pfl776 249 1 Since since IN cord-300061-l2pfl776 249 2 , , , cord-300061-l2pfl776 249 3 by by IN cord-300061-l2pfl776 249 4 Watson Watson NNP cord-300061-l2pfl776 249 5 - - HYPH cord-300061-l2pfl776 249 6 Crick Crick NNP cord-300061-l2pfl776 249 7 base base NN cord-300061-l2pfl776 249 8 - - HYPH cord-300061-l2pfl776 249 9 pairing pair VBG cord-300061-l2pfl776 249 10 rules rule NNS cord-300061-l2pfl776 249 11 , , , cord-300061-l2pfl776 249 12 we -PRON- PRP cord-300061-l2pfl776 249 13 only only RB cord-300061-l2pfl776 249 14 have have VBP cord-300061-l2pfl776 249 15 C C NNP cord-300061-l2pfl776 249 16 - - HYPH cord-300061-l2pfl776 249 17 G G NNP cord-300061-l2pfl776 249 18 / / SYM cord-300061-l2pfl776 249 19 G G NNP cord-300061-l2pfl776 249 20 - - HYPH cord-300061-l2pfl776 249 21 C C NNP cord-300061-l2pfl776 249 22 and and CC cord-300061-l2pfl776 249 23 A a NN cord-300061-l2pfl776 250 1 -T -T : cord-300061-l2pfl776 250 2 / / SYM cord-300061-l2pfl776 250 3 T T NNP cord-300061-l2pfl776 250 4 - - HYPH cord-300061-l2pfl776 250 5 A A NNP cord-300061-l2pfl776 250 6 pairs pair NNS cord-300061-l2pfl776 250 7 , , , cord-300061-l2pfl776 250 8 this this DT cord-300061-l2pfl776 250 9 implies imply VBZ cord-300061-l2pfl776 250 10 that that IN cord-300061-l2pfl776 250 11 APPROXIMATELY approximately JJ cord-300061-l2pfl776 250 12 f_a f_a NN cord-300061-l2pfl776 250 13 = = SYM cord-300061-l2pfl776 250 14 f_t f_t NN cord-300061-l2pfl776 250 15 and and CC cord-300061-l2pfl776 250 16 f_c f_c NN cord-300061-l2pfl776 250 17 = = SYM cord-300061-l2pfl776 250 18 f_g f_g NN cord-300061-l2pfl776 250 19 ( ( -LRB- cord-300061-l2pfl776 250 20 * * NFP cord-300061-l2pfl776 250 21 ) ) -RRB- cord-300061-l2pfl776 250 22 Now now RB cord-300061-l2pfl776 250 23 , , , cord-300061-l2pfl776 250 24 if if IN cord-300061-l2pfl776 250 25 we -PRON- PRP cord-300061-l2pfl776 250 26 assume assume VBP cord-300061-l2pfl776 250 27 that that IN cord-300061-l2pfl776 250 28 the the DT cord-300061-l2pfl776 250 29 equalities equality NNS cord-300061-l2pfl776 250 30 ( ( -LRB- cord-300061-l2pfl776 250 31 * * NFP cord-300061-l2pfl776 250 32 ) ) -RRB- cord-300061-l2pfl776 250 33 hold hold VB cord-300061-l2pfl776 250 34 exactly exactly RB cord-300061-l2pfl776 250 35 , , , cord-300061-l2pfl776 250 36 then then RB cord-300061-l2pfl776 250 37 we -PRON- PRP cord-300061-l2pfl776 250 38 have have VBP cord-300061-l2pfl776 250 39 three three CD cord-300061-l2pfl776 250 40 constraints constraint NNS cord-300061-l2pfl776 251 1 f_a+f_c+f_g+f_t f_a+f_c+f_g+f_t NNP cord-300061-l2pfl776 251 2 = = SYM cord-300061-l2pfl776 251 3 1 1 CD cord-300061-l2pfl776 251 4 f_a f_a CD cord-300061-l2pfl776 251 5 = = SYM cord-300061-l2pfl776 251 6 f_t f_t NNP cord-300061-l2pfl776 251 7 f_c f_c NN cord-300061-l2pfl776 251 8 = = SYM cord-300061-l2pfl776 251 9 f_g f_g NN cord-300061-l2pfl776 252 1 and and CC cord-300061-l2pfl776 252 2 so so RB cord-300061-l2pfl776 252 3 we -PRON- PRP cord-300061-l2pfl776 252 4 effectively effectively RB cord-300061-l2pfl776 252 5 have have VBP cord-300061-l2pfl776 252 6 only only RB cord-300061-l2pfl776 252 7 1 1 CD cord-300061-l2pfl776 252 8 degree degree NN cord-300061-l2pfl776 252 9 of of IN cord-300061-l2pfl776 252 10 freedom freedom NN cord-300061-l2pfl776 252 11 left leave VBN cord-300061-l2pfl776 252 12 ( ( -LRB- cord-300061-l2pfl776 252 13 which which WDT cord-300061-l2pfl776 252 14 is be VBZ cord-300061-l2pfl776 252 15 essentially essentially RB cord-300061-l2pfl776 252 16 GC gc NN cord-300061-l2pfl776 252 17 - - HYPH cord-300061-l2pfl776 252 18 content content NN cord-300061-l2pfl776 252 19 ) ) -RRB- cord-300061-l2pfl776 252 20 . . . cord-300061-l2pfl776 253 1 Since since IN cord-300061-l2pfl776 253 2 both both DT cord-300061-l2pfl776 253 3 S S NNP cord-300061-l2pfl776 253 4 and and CC cord-300061-l2pfl776 253 5 H H NNP cord-300061-l2pfl776 253 6 are be VBP cord-300061-l2pfl776 253 7 invertible invertible JJ cord-300061-l2pfl776 253 8 functions function NNS cord-300061-l2pfl776 253 9 of of IN cord-300061-l2pfl776 253 10 the the DT cord-300061-l2pfl776 253 11 remaining remain VBG cord-300061-l2pfl776 253 12 degree degree NN cord-300061-l2pfl776 253 13 of of IN cord-300061-l2pfl776 253 14 freedom freedom NN cord-300061-l2pfl776 253 15 , , , cord-300061-l2pfl776 253 16 it -PRON- PRP cord-300061-l2pfl776 253 17 immediately immediately RB cord-300061-l2pfl776 253 18 follows follow VBZ cord-300061-l2pfl776 253 19 that that IN cord-300061-l2pfl776 253 20 S S NNP cord-300061-l2pfl776 253 21 can can MD cord-300061-l2pfl776 253 22 be be VB cord-300061-l2pfl776 253 23 calculated calculate VBN cord-300061-l2pfl776 253 24 from from IN cord-300061-l2pfl776 253 25 H H NNP cord-300061-l2pfl776 253 26 and and CC cord-300061-l2pfl776 253 27 H H NNP cord-300061-l2pfl776 253 28 from from IN cord-300061-l2pfl776 253 29 S. S. NNP cord-300061-l2pfl776 254 1 Whether whether IN cord-300061-l2pfl776 254 2 you -PRON- PRP cord-300061-l2pfl776 254 3 want want VBP cord-300061-l2pfl776 254 4 to to TO cord-300061-l2pfl776 254 5 call call VB cord-300061-l2pfl776 254 6 this this DT cord-300061-l2pfl776 254 7 equivalent equivalent NN cord-300061-l2pfl776 254 8 or or CC cord-300061-l2pfl776 254 9 not not RB cord-300061-l2pfl776 254 10 is be VBZ cord-300061-l2pfl776 254 11 a a DT cord-300061-l2pfl776 254 12 matter matter NN cord-300061-l2pfl776 254 13 of of IN cord-300061-l2pfl776 254 14 semantics semantic NNS cord-300061-l2pfl776 254 15 . . . cord-300061-l2pfl776 255 1 The the DT cord-300061-l2pfl776 255 2 point point NN cord-300061-l2pfl776 255 3 is be VBZ cord-300061-l2pfl776 255 4 that that IN cord-300061-l2pfl776 255 5 when when WRB cord-300061-l2pfl776 255 6 all all DT cord-300061-l2pfl776 255 7 three three CD cord-300061-l2pfl776 255 8 constrains constrain NNS cord-300061-l2pfl776 255 9 are be VBP cord-300061-l2pfl776 255 10 acting act VBG cord-300061-l2pfl776 255 11 , , , cord-300061-l2pfl776 255 12 there there EX cord-300061-l2pfl776 255 13 is be VBZ cord-300061-l2pfl776 255 14 only only RB cord-300061-l2pfl776 255 15 one one CD cord-300061-l2pfl776 255 16 degree degree NN cord-300061-l2pfl776 255 17 of of IN cord-300061-l2pfl776 255 18 freedom freedom NN cord-300061-l2pfl776 255 19 left leave VBN cord-300061-l2pfl776 255 20 . . . cord-300061-l2pfl776 256 1 Instead instead RB cord-300061-l2pfl776 256 2 of of IN cord-300061-l2pfl776 256 3 calculating calculate VBG cord-300061-l2pfl776 256 4 S S NNP cord-300061-l2pfl776 256 5 or or CC cord-300061-l2pfl776 256 6 H H NNP cord-300061-l2pfl776 256 7 , , , cord-300061-l2pfl776 256 8 I -PRON- PRP cord-300061-l2pfl776 256 9 think think VBP cord-300061-l2pfl776 256 10 it -PRON- PRP cord-300061-l2pfl776 256 11 would would MD cord-300061-l2pfl776 256 12 be be VB cord-300061-l2pfl776 256 13 much much RB cord-300061-l2pfl776 256 14 more more RBR cord-300061-l2pfl776 256 15 straight straight RB cord-300061-l2pfl776 256 16 - - HYPH cord-300061-l2pfl776 256 17 forward forward NN cord-300061-l2pfl776 256 18 to to IN cord-300061-l2pfl776 256 19 just just RB cord-300061-l2pfl776 256 20 talk talk VB cord-300061-l2pfl776 256 21 about about IN cord-300061-l2pfl776 256 22 GC gc NN cord-300061-l2pfl776 256 23 - - HYPH cord-300061-l2pfl776 256 24 content content NN cord-300061-l2pfl776 256 25 directly directly RB cord-300061-l2pfl776 256 26 . . . cord-300061-l2pfl776 257 1 Indeed indeed RB cord-300061-l2pfl776 257 2 , , , cord-300061-l2pfl776 257 3 it -PRON- PRP cord-300061-l2pfl776 257 4 is be VBZ cord-300061-l2pfl776 257 5 remarkable remarkable JJ cord-300061-l2pfl776 257 6 that that IN cord-300061-l2pfl776 257 7 CG cg NN cord-300061-l2pfl776 257 8 - - HYPH cord-300061-l2pfl776 257 9 content content NN cord-300061-l2pfl776 257 10 ranges range NNS cord-300061-l2pfl776 257 11 from from IN cord-300061-l2pfl776 257 12 as as RB cord-300061-l2pfl776 257 13 low low JJ cord-300061-l2pfl776 257 14 as as IN cord-300061-l2pfl776 257 15 0.22 0.22 CD cord-300061-l2pfl776 257 16 to to IN cord-300061-l2pfl776 257 17 as as RB cord-300061-l2pfl776 257 18 high high JJ cord-300061-l2pfl776 257 19 as as IN cord-300061-l2pfl776 257 20 0.77 0.77 CD cord-300061-l2pfl776 257 21 and and CC cord-300061-l2pfl776 257 22 the the DT cord-300061-l2pfl776 257 23 relevant relevant JJ cord-300061-l2pfl776 257 24 biological biological JJ cord-300061-l2pfl776 257 25 question question NN cord-300061-l2pfl776 257 26 , , , cord-300061-l2pfl776 257 27 in in IN cord-300061-l2pfl776 257 28 my -PRON- PRP$ cord-300061-l2pfl776 257 29 opinion opinion NN cord-300061-l2pfl776 257 30 , , , cord-300061-l2pfl776 257 31 is be VBZ cord-300061-l2pfl776 257 32 not not RB cord-300061-l2pfl776 257 33 whether whether IN cord-300061-l2pfl776 257 34 to to TO cord-300061-l2pfl776 257 35 use use VB cord-300061-l2pfl776 257 36 S S NNP cord-300061-l2pfl776 257 37 or or CC cord-300061-l2pfl776 257 38 H H NNP cord-300061-l2pfl776 257 39 or or CC cord-300061-l2pfl776 257 40 whatever whatever WDT cord-300061-l2pfl776 257 41 other other JJ cord-300061-l2pfl776 257 42 derived derive VBN cord-300061-l2pfl776 257 43 statistic statistic NN cord-300061-l2pfl776 257 44 , , , cord-300061-l2pfl776 257 45 but but CC cord-300061-l2pfl776 257 46 rather rather RB cord-300061-l2pfl776 257 47 trying try VBG cord-300061-l2pfl776 257 48 to to TO cord-300061-l2pfl776 257 49 explain explain VB cord-300061-l2pfl776 257 50 why why WRB cord-300061-l2pfl776 257 51 GCcontent GCcontent NNP cord-300061-l2pfl776 257 52 varies vary VBZ cord-300061-l2pfl776 257 53 so so RB cord-300061-l2pfl776 257 54 much much RB cord-300061-l2pfl776 257 55 in in IN cord-300061-l2pfl776 257 56 bacterial bacterial JJ cord-300061-l2pfl776 257 57 genomes genome NNS cord-300061-l2pfl776 257 58 . . . cord-300061-l2pfl776 258 1 Indeed indeed RB cord-300061-l2pfl776 258 2 there there EX cord-300061-l2pfl776 258 3 has have VBZ cord-300061-l2pfl776 258 4 been be VBN cord-300061-l2pfl776 258 5 quite quite RB cord-300061-l2pfl776 258 6 some some DT cord-300061-l2pfl776 258 7 interesting interesting JJ cord-300061-l2pfl776 258 8 developments development NNS cord-300061-l2pfl776 258 9 in in IN cord-300061-l2pfl776 258 10 this this DT cord-300061-l2pfl776 258 11 area area NN cord-300061-l2pfl776 258 12 recently recently RB cord-300061-l2pfl776 258 13 . . . cord-300061-l2pfl776 259 1 See see VB cord-300061-l2pfl776 259 2 for for IN cord-300061-l2pfl776 259 3 example example NN cord-300061-l2pfl776 259 4 the the DT cord-300061-l2pfl776 259 5 discussion discussion NN cord-300061-l2pfl776 259 6 in in IN cord-300061-l2pfl776 259 7 : : : cord-300061-l2pfl776 260 1 Rocha Rocha NNP cord-300061-l2pfl776 260 2 EP EP NNP cord-300061-l2pfl776 260 3 , , , cord-300061-l2pfl776 260 4 Feil Feil NNP cord-300061-l2pfl776 260 5 EJ EJ NNP cord-300061-l2pfl776 260 6 . . . cord-300061-l2pfl776 261 1 Mutational mutational JJ cord-300061-l2pfl776 261 2 patterns pattern NNS cord-300061-l2pfl776 261 3 can can MD cord-300061-l2pfl776 261 4 not not RB cord-300061-l2pfl776 261 5 explain explain VB cord-300061-l2pfl776 261 6 genome genome NN cord-300061-l2pfl776 261 7 composition composition NN cord-300061-l2pfl776 261 8 : : : cord-300061-l2pfl776 261 9 are be VBP cord-300061-l2pfl776 261 10 there there EX cord-300061-l2pfl776 261 11 any any DT cord-300061-l2pfl776 261 12 neutral neutral JJ cord-300061-l2pfl776 261 13 sites site NNS cord-300061-l2pfl776 261 14 in in IN cord-300061-l2pfl776 261 15 the the DT cord-300061-l2pfl776 261 16 genomes genome NNS cord-300061-l2pfl776 261 17 of of IN cord-300061-l2pfl776 261 18 bacteria bacteria NNS cord-300061-l2pfl776 261 19 ? ? . cord-300061-l2pfl776 262 1 PLoS PLoS NNP cord-300061-l2pfl776 262 2 Genet Genet NNP cord-300061-l2pfl776 262 3 . . . cord-300061-l2pfl776 263 1 2010 2010 CD cord-300061-l2pfl776 263 2 Sep Sep NNP cord-300061-l2pfl776 263 3 9;6(9 9;6(9 CD cord-300061-l2pfl776 263 4 ) ) -RRB- cord-300061-l2pfl776 263 5 . . . cord-300061-l2pfl776 264 1 The the DT cord-300061-l2pfl776 264 2 discussion discussion NN cord-300061-l2pfl776 264 3 about about IN cord-300061-l2pfl776 264 4 Renyi Renyi NNP cord-300061-l2pfl776 264 5 entropies entropy NNS cord-300061-l2pfl776 264 6 is be VBZ cord-300061-l2pfl776 264 7 useless useless JJ cord-300061-l2pfl776 264 8 in in IN cord-300061-l2pfl776 264 9 my -PRON- PRP$ cord-300061-l2pfl776 264 10 opinion opinion NN cord-300061-l2pfl776 264 11 . . . cord-300061-l2pfl776 265 1 Yes yes UH cord-300061-l2pfl776 265 2 , , , cord-300061-l2pfl776 265 3 both both CC cord-300061-l2pfl776 265 4 S S NNP cord-300061-l2pfl776 265 5 and and CC cord-300061-l2pfl776 265 6 H H NNP cord-300061-l2pfl776 265 7 are be VBP cord-300061-l2pfl776 265 8 both both DT cord-300061-l2pfl776 265 9 members member NNS cord-300061-l2pfl776 265 10 of of IN cord-300061-l2pfl776 265 11 a a DT cord-300061-l2pfl776 265 12 family family NN cord-300061-l2pfl776 265 13 of of IN cord-300061-l2pfl776 265 14 functions function NNS cord-300061-l2pfl776 265 15 ( ( -LRB- cord-300061-l2pfl776 265 16 Renyi Renyi NNP cord-300061-l2pfl776 265 17 entropies entropy NNS cord-300061-l2pfl776 265 18 ) ) -RRB- cord-300061-l2pfl776 265 19 but but CC cord-300061-l2pfl776 266 1 I -PRON- PRP cord-300061-l2pfl776 266 2 fail fail VBP cord-300061-l2pfl776 266 3 to to TO cord-300061-l2pfl776 266 4 see see VB cord-300061-l2pfl776 266 5 how how WRB cord-300061-l2pfl776 266 6 this this DT cord-300061-l2pfl776 266 7 is be VBZ cord-300061-l2pfl776 266 8 relevant relevant JJ cord-300061-l2pfl776 266 9 for for IN cord-300061-l2pfl776 266 10 any any DT cord-300061-l2pfl776 266 11 biological biological JJ cord-300061-l2pfl776 266 12 question question NN cord-300061-l2pfl776 266 13 . . . cord-300061-l2pfl776 267 1 Of of RB cord-300061-l2pfl776 267 2 course course RB cord-300061-l2pfl776 267 3 , , , cord-300061-l2pfl776 267 4 in in IN cord-300061-l2pfl776 267 5 reality reality NN cord-300061-l2pfl776 267 6 one one CD cord-300061-l2pfl776 267 7 only only RB cord-300061-l2pfl776 267 8 has have VBZ cord-300061-l2pfl776 267 9 that that DT cord-300061-l2pfl776 267 10 f_a f_a NN cord-300061-l2pfl776 267 11 is be VBZ cord-300061-l2pfl776 267 12 approximately approximately RB cord-300061-l2pfl776 267 13 equal equal JJ cord-300061-l2pfl776 267 14 to to IN cord-300061-l2pfl776 267 15 f_t f_t NNP cord-300061-l2pfl776 267 16 ( ( -LRB- cord-300061-l2pfl776 267 17 and and CC cord-300061-l2pfl776 267 18 similar similar JJ cord-300061-l2pfl776 267 19 for for IN cord-300061-l2pfl776 267 20 f_c f_c NN cord-300061-l2pfl776 267 21 and and CC cord-300061-l2pfl776 267 22 f_g f_g NN cord-300061-l2pfl776 267 23 ) ) -RRB- cord-300061-l2pfl776 267 24 . . . cord-300061-l2pfl776 268 1 Thus thus RB cord-300061-l2pfl776 268 2 , , , cord-300061-l2pfl776 268 3 H H NNP cord-300061-l2pfl776 268 4 and and CC cord-300061-l2pfl776 268 5 S S NNP cord-300061-l2pfl776 268 6 may may MD cord-300061-l2pfl776 268 7 vary vary VB cord-300061-l2pfl776 268 8 independently independently RB cord-300061-l2pfl776 268 9 . . . cord-300061-l2pfl776 269 1 However however RB cord-300061-l2pfl776 269 2 , , , cord-300061-l2pfl776 269 3 because because IN cord-300061-l2pfl776 269 4 the the DT cord-300061-l2pfl776 269 5 equalities equality NNS cord-300061-l2pfl776 269 6 almost almost RB cord-300061-l2pfl776 269 7 always always RB cord-300061-l2pfl776 269 8 very very RB cord-300061-l2pfl776 269 9 nearly nearly RB cord-300061-l2pfl776 269 10 hold hold VBP cord-300061-l2pfl776 269 11 , , , cord-300061-l2pfl776 269 12 and and CC cord-300061-l2pfl776 269 13 because because IN cord-300061-l2pfl776 269 14 H H NNP cord-300061-l2pfl776 269 15 and and CC cord-300061-l2pfl776 269 16 S S NNP cord-300061-l2pfl776 269 17 are be VBP cord-300061-l2pfl776 269 18 smooth smooth JJ cord-300061-l2pfl776 269 19 functions function NNS cord-300061-l2pfl776 269 20 of of IN cord-300061-l2pfl776 269 21 the the DT cord-300061-l2pfl776 269 22 base base NN cord-300061-l2pfl776 269 23 frequencies frequency NNS cord-300061-l2pfl776 269 24 , , , cord-300061-l2pfl776 269 25 there there EX cord-300061-l2pfl776 269 26 is be VBZ cord-300061-l2pfl776 269 27 still still RB cord-300061-l2pfl776 269 28 a a DT cord-300061-l2pfl776 269 29 very very RB cord-300061-l2pfl776 269 30 tight tight JJ cord-300061-l2pfl776 269 31 quantitative quantitative JJ cord-300061-l2pfl776 269 32 relation relation NN cord-300061-l2pfl776 269 33 between between IN cord-300061-l2pfl776 269 34 H H NNP cord-300061-l2pfl776 269 35 and and CC cord-300061-l2pfl776 269 36 S S NNP cord-300061-l2pfl776 269 37 in in IN cord-300061-l2pfl776 269 38 real real JJ cord-300061-l2pfl776 269 39 data datum NNS cord-300061-l2pfl776 269 40 . . . cord-300061-l2pfl776 270 1 Thus thus RB cord-300061-l2pfl776 270 2 , , , cord-300061-l2pfl776 270 3 I -PRON- PRP cord-300061-l2pfl776 270 4 agree agree VBP cord-300061-l2pfl776 270 5 with with IN cord-300061-l2pfl776 270 6 Elhaik Elhaik NNP cord-300061-l2pfl776 270 7 et et NNP cord-300061-l2pfl776 270 8 al al NNP cord-300061-l2pfl776 270 9 . . . cord-300061-l2pfl776 271 1 that that IN cord-300061-l2pfl776 271 2 the the DT cord-300061-l2pfl776 271 3 variation variation NN cord-300061-l2pfl776 271 4 of of IN cord-300061-l2pfl776 271 5 S S NNP cord-300061-l2pfl776 271 6 and and CC cord-300061-l2pfl776 271 7 H H NNP cord-300061-l2pfl776 271 8 across across IN cord-300061-l2pfl776 271 9 different different JJ cord-300061-l2pfl776 271 10 genomes genome NNS cord-300061-l2pfl776 271 11 is be VBZ cord-300061-l2pfl776 271 12 dominated dominate VBN cord-300061-l2pfl776 271 13 by by IN cord-300061-l2pfl776 271 14 the the DT cord-300061-l2pfl776 271 15 variation variation NN cord-300061-l2pfl776 271 16 in in IN cord-300061-l2pfl776 271 17 GC gc NN cord-300061-l2pfl776 271 18 - - HYPH cord-300061-l2pfl776 271 19 content content NN cord-300061-l2pfl776 271 20 . . . cord-300061-l2pfl776 272 1 2 2 LS cord-300061-l2pfl776 272 2 ) ) -RRB- cord-300061-l2pfl776 273 1 The the DT cord-300061-l2pfl776 273 2 remaining remain VBG cord-300061-l2pfl776 273 3 question question NN cord-300061-l2pfl776 273 4 is be VBZ cord-300061-l2pfl776 273 5 whether whether IN cord-300061-l2pfl776 273 6 there there EX cord-300061-l2pfl776 273 7 is be VBZ cord-300061-l2pfl776 273 8 any any DT cord-300061-l2pfl776 273 9 biological biological JJ cord-300061-l2pfl776 273 10 meaning meaning NN cord-300061-l2pfl776 273 11 in in IN cord-300061-l2pfl776 273 12 the the DT cord-300061-l2pfl776 273 13 deviations deviation NNS cord-300061-l2pfl776 273 14 from from IN cord-300061-l2pfl776 273 15 f_c f_c NN cord-300061-l2pfl776 273 16 = = SYM cord-300061-l2pfl776 273 17 f_g f_g NN cord-300061-l2pfl776 273 18 and and CC cord-300061-l2pfl776 273 19 f_a f_a NN cord-300061-l2pfl776 273 20 = = SYM cord-300061-l2pfl776 273 21 f_t f_t NN cord-300061-l2pfl776 273 22 . . . cord-300061-l2pfl776 274 1 The the DT cord-300061-l2pfl776 274 2 current current JJ cord-300061-l2pfl776 274 3 author author NN cord-300061-l2pfl776 274 4 makes make VBZ cord-300061-l2pfl776 274 5 the the DT cord-300061-l2pfl776 274 6 valid valid JJ cord-300061-l2pfl776 274 7 point point NN cord-300061-l2pfl776 274 8 , , , cord-300061-l2pfl776 274 9 in in IN cord-300061-l2pfl776 274 10 my -PRON- PRP$ cord-300061-l2pfl776 274 11 opinion opinion NN cord-300061-l2pfl776 274 12 , , , cord-300061-l2pfl776 274 13 that that IN cord-300061-l2pfl776 274 14 numerically numerically RB cord-300061-l2pfl776 274 15 small small JJ cord-300061-l2pfl776 274 16 deviations deviation NNS cord-300061-l2pfl776 274 17 may may MD cord-300061-l2pfl776 274 18 still still RB cord-300061-l2pfl776 274 19 be be VB cord-300061-l2pfl776 274 20 meaningful meaningful JJ cord-300061-l2pfl776 274 21 biologically biologically RB cord-300061-l2pfl776 274 22 . . . cord-300061-l2pfl776 275 1 The the DT cord-300061-l2pfl776 275 2 author author NN cord-300061-l2pfl776 275 3 asserts assert VBZ cord-300061-l2pfl776 275 4 in in IN cord-300061-l2pfl776 275 5 several several JJ cord-300061-l2pfl776 275 6 places place NNS cord-300061-l2pfl776 275 7 that that WDT cord-300061-l2pfl776 275 8 , , , cord-300061-l2pfl776 275 9 indeed indeed RB cord-300061-l2pfl776 275 10 , , , cord-300061-l2pfl776 275 11 these these DT cord-300061-l2pfl776 275 12 deviations deviation NNS cord-300061-l2pfl776 275 13 are be VBP cord-300061-l2pfl776 275 14 highly highly RB cord-300061-l2pfl776 275 15 meaningful meaningful JJ cord-300061-l2pfl776 275 16 but but CC cord-300061-l2pfl776 275 17 frustratingly frustratingly RB cord-300061-l2pfl776 275 18 fails fail VBZ cord-300061-l2pfl776 275 19 to to TO cord-300061-l2pfl776 275 20 give give VB cord-300061-l2pfl776 275 21 citations citation NNS cord-300061-l2pfl776 275 22 to to TO cord-300061-l2pfl776 275 23 back back VB cord-300061-l2pfl776 275 24 this this DT cord-300061-l2pfl776 275 25 claim claim NN cord-300061-l2pfl776 275 26 up up RP cord-300061-l2pfl776 275 27 . . . cord-300061-l2pfl776 276 1 My -PRON- PRP$ cord-300061-l2pfl776 276 2 own own JJ cord-300061-l2pfl776 276 3 recollection recollection NN cord-300061-l2pfl776 276 4 is be VBZ cord-300061-l2pfl776 276 5 that that IN cord-300061-l2pfl776 276 6 in in IN cord-300061-l2pfl776 276 7 bacteria bacteria NNS cord-300061-l2pfl776 276 8 the the DT cord-300061-l2pfl776 276 9 G/ G/ NNP cord-300061-l2pfl776 276 10 C C NNP cord-300061-l2pfl776 276 11 - - HYPH cord-300061-l2pfl776 276 12 skew skew NNP cord-300061-l2pfl776 276 13 has have VBZ cord-300061-l2pfl776 276 14 been be VBN cord-300061-l2pfl776 276 15 proposed propose VBN cord-300061-l2pfl776 276 16 to to TO cord-300061-l2pfl776 276 17 be be VB cord-300061-l2pfl776 276 18 a a DT cord-300061-l2pfl776 276 19 result result NN cord-300061-l2pfl776 276 20 of of IN cord-300061-l2pfl776 276 21 different different JJ cord-300061-l2pfl776 276 22 mutational mutational JJ cord-300061-l2pfl776 276 23 spectra spectrum NNS cord-300061-l2pfl776 276 24 acting act VBG cord-300061-l2pfl776 276 25 on on IN cord-300061-l2pfl776 276 26 the the DT cord-300061-l2pfl776 276 27 leading lead VBG cord-300061-l2pfl776 276 28 and and CC cord-300061-l2pfl776 276 29 lagging lagging JJ cord-300061-l2pfl776 276 30 strands strand NNS cord-300061-l2pfl776 276 31 ( ( -LRB- cord-300061-l2pfl776 276 32 and and CC cord-300061-l2pfl776 276 33 would would MD cord-300061-l2pfl776 276 34 thus thus RB cord-300061-l2pfl776 276 35 not not RB cord-300061-l2pfl776 276 36 necessarily necessarily RB cord-300061-l2pfl776 276 37 have have VB cord-300061-l2pfl776 276 38 functional functional JJ cord-300061-l2pfl776 276 39 implications implication NNS cord-300061-l2pfl776 276 40 ) ) -RRB- cord-300061-l2pfl776 276 41 . . . cord-300061-l2pfl776 277 1 The the DT cord-300061-l2pfl776 277 2 author author NN cord-300061-l2pfl776 277 3 does do VBZ cord-300061-l2pfl776 277 4 later later RB cord-300061-l2pfl776 277 5 cite cite VB cord-300061-l2pfl776 277 6 a a DT cord-300061-l2pfl776 277 7 number number NN cord-300061-l2pfl776 277 8 of of IN cord-300061-l2pfl776 277 9 papers paper NNS cord-300061-l2pfl776 277 10 that that WDT cord-300061-l2pfl776 277 11 use use VBP cord-300061-l2pfl776 277 12 the the DT cord-300061-l2pfl776 277 13 Z z NN cord-300061-l2pfl776 277 14 - - HYPH cord-300061-l2pfl776 277 15 curve curve NN cord-300061-l2pfl776 277 16 statistic statistic NN cord-300061-l2pfl776 277 17 to to TO cord-300061-l2pfl776 277 18 find find VB cord-300061-l2pfl776 277 19 genes gene NNS cord-300061-l2pfl776 277 20 and and CC cord-300061-l2pfl776 277 21 replication replication NN cord-300061-l2pfl776 277 22 origins origin NNS cord-300061-l2pfl776 277 23 and and CC cord-300061-l2pfl776 277 24 states state VBZ cord-300061-l2pfl776 277 25 that that IN cord-300061-l2pfl776 277 26 the the DT cord-300061-l2pfl776 277 27 components component NNS cord-300061-l2pfl776 277 28 orthogonal orthogonal JJ cord-300061-l2pfl776 277 29 to to IN cord-300061-l2pfl776 277 30 GCcontent GCcontent NNP cord-300061-l2pfl776 277 31 are be VBP cord-300061-l2pfl776 277 32 crucial crucial JJ cord-300061-l2pfl776 277 33 for for IN cord-300061-l2pfl776 277 34 these these DT cord-300061-l2pfl776 277 35 methods method NNS cord-300061-l2pfl776 277 36 . . . cord-300061-l2pfl776 278 1 I -PRON- PRP cord-300061-l2pfl776 278 2 immediately immediately RB cord-300061-l2pfl776 278 3 believe believe VBP cord-300061-l2pfl776 278 4 this this DT cord-300061-l2pfl776 278 5 to to TO cord-300061-l2pfl776 278 6 be be VB cord-300061-l2pfl776 278 7 correct correct JJ cord-300061-l2pfl776 278 8 . . . cord-300061-l2pfl776 279 1 For for IN cord-300061-l2pfl776 279 2 example example NN cord-300061-l2pfl776 279 3 , , , cord-300061-l2pfl776 279 4 as as IN cord-300061-l2pfl776 279 5 we -PRON- PRP cord-300061-l2pfl776 279 6 and and CC cord-300061-l2pfl776 279 7 others other NNS cord-300061-l2pfl776 279 8 have have VBP cord-300061-l2pfl776 279 9 found find VBN cord-300061-l2pfl776 279 10 the the DT cord-300061-l2pfl776 279 11 presence presence NN cord-300061-l2pfl776 279 12 of of IN cord-300061-l2pfl776 279 13 ribosomal ribosomal JJ cord-300061-l2pfl776 279 14 binding bind VBG cord-300061-l2pfl776 279 15 sites site NNS cord-300061-l2pfl776 279 16 plus plus CC cord-300061-l2pfl776 279 17 the the DT cord-300061-l2pfl776 279 18 avoidance avoidance NN cord-300061-l2pfl776 279 19 of of IN cord-300061-l2pfl776 279 20 RNA RNA NNP cord-300061-l2pfl776 279 21 secondary secondary JJ cord-300061-l2pfl776 279 22 structure structure NN cord-300061-l2pfl776 279 23 around around IN cord-300061-l2pfl776 279 24 the the DT cord-300061-l2pfl776 279 25 translation translation NN cord-300061-l2pfl776 279 26 start start NN cord-300061-l2pfl776 279 27 site site NN cord-300061-l2pfl776 279 28 leads lead VBZ cord-300061-l2pfl776 279 29 to to IN cord-300061-l2pfl776 279 30 clear clear JJ cord-300061-l2pfl776 279 31 base base JJ cord-300061-l2pfl776 279 32 - - HYPH cord-300061-l2pfl776 279 33 compositional compositional JJ cord-300061-l2pfl776 279 34 biases bias NNS cord-300061-l2pfl776 279 35 around around IN cord-300061-l2pfl776 279 36 the the DT cord-300061-l2pfl776 279 37 starts start NNS cord-300061-l2pfl776 279 38 of of IN cord-300061-l2pfl776 279 39 genes gene NNS cord-300061-l2pfl776 279 40 ( ( -LRB- cord-300061-l2pfl776 279 41 Eyre Eyre NNP cord-300061-l2pfl776 279 42 - - HYPH cord-300061-l2pfl776 279 43 Walker Walker NNP cord-300061-l2pfl776 279 44 and and CC cord-300061-l2pfl776 279 45 Bulmer Bulmer NNP cord-300061-l2pfl776 279 46 Nucl Nucl NNP cord-300061-l2pfl776 279 47 . . . cord-300061-l2pfl776 280 1 Acids acid NNS cord-300061-l2pfl776 280 2 Res Res NNP cord-300061-l2pfl776 280 3 1993 1993 CD cord-300061-l2pfl776 280 4 , , , cord-300061-l2pfl776 280 5 Molina Molina NNP cord-300061-l2pfl776 280 6 & & CC cord-300061-l2pfl776 280 7 van van NNP cord-300061-l2pfl776 280 8 Nimwegen Nimwegen NNP cord-300061-l2pfl776 280 9 Genome Genome NNP cord-300061-l2pfl776 280 10 Res Res NNP cord-300061-l2pfl776 280 11 2008 2008 CD cord-300061-l2pfl776 280 12 ) ) -RRB- cord-300061-l2pfl776 280 13 . . . cord-300061-l2pfl776 281 1 However however RB cord-300061-l2pfl776 281 2 , , , cord-300061-l2pfl776 281 3 this this DT cord-300061-l2pfl776 281 4 seems seem VBZ cord-300061-l2pfl776 281 5 to to TO cord-300061-l2pfl776 281 6 now now RB cord-300061-l2pfl776 281 7 confound confound VB cord-300061-l2pfl776 281 8 the the DT cord-300061-l2pfl776 281 9 question question NN cord-300061-l2pfl776 281 10 of of IN cord-300061-l2pfl776 281 11 local local JJ cord-300061-l2pfl776 281 12 compositional compositional JJ cord-300061-l2pfl776 281 13 biases bias NNS cord-300061-l2pfl776 281 14 and and CC cord-300061-l2pfl776 281 15 their -PRON- PRP$ cord-300061-l2pfl776 281 16 functional functional JJ cord-300061-l2pfl776 281 17 implications implication NNS cord-300061-l2pfl776 281 18 versus versus IN cord-300061-l2pfl776 281 19 global global JJ cord-300061-l2pfl776 281 20 patterns pattern NNS cord-300061-l2pfl776 281 21 of of IN cord-300061-l2pfl776 281 22 base base NN cord-300061-l2pfl776 281 23 composition composition NN cord-300061-l2pfl776 281 24 , , , cord-300061-l2pfl776 281 25 because because IN cord-300061-l2pfl776 281 26 as as RB cord-300061-l2pfl776 281 27 far far RB cord-300061-l2pfl776 281 28 as as IN cord-300061-l2pfl776 281 29 I -PRON- PRP cord-300061-l2pfl776 281 30 can can MD cord-300061-l2pfl776 281 31 tell tell VB cord-300061-l2pfl776 281 32 Elhaik Elhaik NNP cord-300061-l2pfl776 281 33 et et NNP cord-300061-l2pfl776 281 34 al al NNP cord-300061-l2pfl776 281 35 . . NNP cord-300061-l2pfl776 281 36 were be VBD cord-300061-l2pfl776 281 37 talking talk VBG cord-300061-l2pfl776 281 38 about about IN cord-300061-l2pfl776 281 39 global global JJ cord-300061-l2pfl776 281 40 compositional compositional JJ cord-300061-l2pfl776 281 41 patterns pattern NNS cord-300061-l2pfl776 281 42 . . . cord-300061-l2pfl776 282 1 Finally finally RB cord-300061-l2pfl776 282 2 , , , cord-300061-l2pfl776 282 3 the the DT cord-300061-l2pfl776 282 4 remark remark NN cord-300061-l2pfl776 282 5 that that IN cord-300061-l2pfl776 282 6 S S NNP cord-300061-l2pfl776 282 7 can can MD cord-300061-l2pfl776 282 8 be be VB cord-300061-l2pfl776 282 9 calculated calculate VBN cord-300061-l2pfl776 282 10 faster fast RBR cord-300061-l2pfl776 282 11 than than IN cord-300061-l2pfl776 282 12 H h NN cord-300061-l2pfl776 282 13 ' ' '' cord-300061-l2pfl776 282 14 which which WDT cord-300061-l2pfl776 282 15 is be VBZ cord-300061-l2pfl776 282 16 especially especially RB cord-300061-l2pfl776 282 17 important important JJ cord-300061-l2pfl776 282 18 for for IN cord-300061-l2pfl776 282 19 handling handle VBG cord-300061-l2pfl776 282 20 large large JJ cord-300061-l2pfl776 282 21 genomes genome NNS cord-300061-l2pfl776 282 22 ' ' '' cord-300061-l2pfl776 282 23 does do VBZ cord-300061-l2pfl776 282 24 not not RB cord-300061-l2pfl776 282 25 make make VB cord-300061-l2pfl776 282 26 a a DT cord-300061-l2pfl776 282 27 lot lot NN cord-300061-l2pfl776 282 28 of of IN cord-300061-l2pfl776 282 29 sense sense NN cord-300061-l2pfl776 282 30 to to IN cord-300061-l2pfl776 282 31 me -PRON- PRP cord-300061-l2pfl776 282 32 . . . cord-300061-l2pfl776 283 1 If if IN cord-300061-l2pfl776 283 2 one one PRP cord-300061-l2pfl776 283 3 really really RB cord-300061-l2pfl776 283 4 worries worry VBZ cord-300061-l2pfl776 283 5 about about IN cord-300061-l2pfl776 283 6 computational computational JJ cord-300061-l2pfl776 283 7 costs cost NNS cord-300061-l2pfl776 283 8 in in IN cord-300061-l2pfl776 283 9 calculating calculate VBG cord-300061-l2pfl776 283 10 H H NNP cord-300061-l2pfl776 283 11 one one PRP cord-300061-l2pfl776 283 12 could could MD cord-300061-l2pfl776 283 13 calculate calculate VB cord-300061-l2pfl776 283 14 f*log(f f*log(f NNP cord-300061-l2pfl776 283 15 ) ) -RRB- cord-300061-l2pfl776 283 16 for for IN cord-300061-l2pfl776 283 17 all all DT cord-300061-l2pfl776 283 18 values value NNS cord-300061-l2pfl776 283 19 of of IN cord-300061-l2pfl776 283 20 before before IN cord-300061-l2pfl776 283 21 - - HYPH cord-300061-l2pfl776 283 22 hand hand NN cord-300061-l2pfl776 283 23 and and CC cord-300061-l2pfl776 283 24 store store VB cord-300061-l2pfl776 283 25 them -PRON- PRP cord-300061-l2pfl776 283 26 in in IN cord-300061-l2pfl776 283 27 a a DT cord-300061-l2pfl776 283 28 table table NN cord-300061-l2pfl776 283 29 . . . cord-300061-l2pfl776 284 1 Author author NN cord-300061-l2pfl776 284 2 's 's POS cord-300061-l2pfl776 284 3 response response NN cord-300061-l2pfl776 284 4 Elhaik Elhaik NNP cord-300061-l2pfl776 284 5 , , , cord-300061-l2pfl776 284 6 Graur Graur NNP cord-300061-l2pfl776 284 7 and and CC cord-300061-l2pfl776 284 8 Josic Josic NNP cord-300061-l2pfl776 284 9 made make VBD cord-300061-l2pfl776 284 10 4 4 CD cord-300061-l2pfl776 284 11 major major JJ cord-300061-l2pfl776 284 12 claims claim NNS cord-300061-l2pfl776 284 13 , , , cord-300061-l2pfl776 284 14 which which WDT cord-300061-l2pfl776 284 15 are be VBP cord-300061-l2pfl776 284 16 rebutted rebut VBN cord-300061-l2pfl776 284 17 . . . cord-300061-l2pfl776 285 1 The the DT cord-300061-l2pfl776 285 2 review review NN cord-300061-l2pfl776 285 3 report report NN cord-300061-l2pfl776 285 4 , , , cord-300061-l2pfl776 285 5 although although IN cord-300061-l2pfl776 285 6 long long RB cord-300061-l2pfl776 285 7 , , , cord-300061-l2pfl776 285 8 evades evade VBZ cord-300061-l2pfl776 285 9 2 2 CD cord-300061-l2pfl776 285 10 major major JJ cord-300061-l2pfl776 285 11 points point NNS cord-300061-l2pfl776 285 12 being be VBG cord-300061-l2pfl776 285 13 debated debate VBN cord-300061-l2pfl776 285 14 . . . cord-300061-l2pfl776 286 1 The the DT cord-300061-l2pfl776 286 2 first first JJ cord-300061-l2pfl776 286 3 2 2 CD cord-300061-l2pfl776 286 4 claims claim NNS cord-300061-l2pfl776 286 5 made make VBN cord-300061-l2pfl776 286 6 by by IN cord-300061-l2pfl776 286 7 Elhaik Elhaik NNP cord-300061-l2pfl776 286 8 et et NNP cord-300061-l2pfl776 286 9 al al NNP cord-300061-l2pfl776 286 10 . . . cord-300061-l2pfl776 287 1 are be VBP cord-300061-l2pfl776 287 2 : : : cord-300061-l2pfl776 287 3 1 1 LS cord-300061-l2pfl776 287 4 ) ) -RRB- cord-300061-l2pfl776 288 1 The the DT cord-300061-l2pfl776 288 2 conclusion conclusion NN cord-300061-l2pfl776 288 3 that that IN cord-300061-l2pfl776 288 4 the the DT cord-300061-l2pfl776 288 5 mapping mapping NN cord-300061-l2pfl776 288 6 points point NNS cord-300061-l2pfl776 288 7 of of IN cord-300061-l2pfl776 288 8 most most JJS cord-300061-l2pfl776 288 9 genomes genome NNS cord-300061-l2pfl776 288 10 are be VBP cord-300061-l2pfl776 288 11 within within IN cord-300061-l2pfl776 288 12 the the DT cord-300061-l2pfl776 288 13 inscribed inscribe VBN cord-300061-l2pfl776 288 14 sphere sphere NN cord-300061-l2pfl776 288 15 , , , cord-300061-l2pfl776 288 16 i.e. i.e. FW cord-300061-l2pfl776 288 17 , , , cord-300061-l2pfl776 288 18 S S NNP cord-300061-l2pfl776 288 19 < < XX cord-300061-l2pfl776 288 20 1/3 1/3 CD cord-300061-l2pfl776 288 21 , , , cord-300061-l2pfl776 288 22 is be VBZ cord-300061-l2pfl776 288 23 a a DT cord-300061-l2pfl776 288 24 consequence consequence NN cord-300061-l2pfl776 288 25 of of IN cord-300061-l2pfl776 288 26 mathematical mathematical JJ cord-300061-l2pfl776 288 27 error error NN cord-300061-l2pfl776 288 28 . . . cord-300061-l2pfl776 289 1 2 2 LS cord-300061-l2pfl776 289 2 ) ) -RRB- cord-300061-l2pfl776 289 3 S S NNP cord-300061-l2pfl776 289 4 follows follow VBZ cord-300061-l2pfl776 289 5 an an DT cord-300061-l2pfl776 289 6 exponential exponential JJ cord-300061-l2pfl776 289 7 distribution distribution NN cord-300061-l2pfl776 289 8 . . . cord-300061-l2pfl776 290 1 I -PRON- PRP cord-300061-l2pfl776 290 2 point point VBP cord-300061-l2pfl776 290 3 out out RP cord-300061-l2pfl776 290 4 that that IN cord-300061-l2pfl776 290 5 their -PRON- PRP$ cord-300061-l2pfl776 290 6 first first JJ cord-300061-l2pfl776 290 7 claim claim NN cord-300061-l2pfl776 290 8 is be VBZ cord-300061-l2pfl776 290 9 incorrect incorrect JJ cord-300061-l2pfl776 290 10 due due IN cord-300061-l2pfl776 290 11 to to IN cord-300061-l2pfl776 290 12 the the DT cord-300061-l2pfl776 290 13 neglect neglect NN cord-300061-l2pfl776 290 14 of of IN cord-300061-l2pfl776 290 15 a a DT cord-300061-l2pfl776 290 16 coordinate coordinate JJ cord-300061-l2pfl776 290 17 transform transform NN cord-300061-l2pfl776 290 18 parameter parameter NN cord-300061-l2pfl776 290 19 and and CC cord-300061-l2pfl776 290 20 their -PRON- PRP$ cord-300061-l2pfl776 290 21 second second JJ cord-300061-l2pfl776 290 22 claim claim NN cord-300061-l2pfl776 290 23 is be VBZ cord-300061-l2pfl776 290 24 only only RB cord-300061-l2pfl776 290 25 a a DT cord-300061-l2pfl776 290 26 restatement restatement NN cord-300061-l2pfl776 290 27 of of IN cord-300061-l2pfl776 290 28 our -PRON- PRP$ cord-300061-l2pfl776 290 29 previous previous JJ cord-300061-l2pfl776 290 30 conclusion conclusion NN cord-300061-l2pfl776 290 31 . . . cord-300061-l2pfl776 291 1 Both both DT cord-300061-l2pfl776 291 2 points point NNS cord-300061-l2pfl776 291 3 are be VBP cord-300061-l2pfl776 291 4 not not RB cord-300061-l2pfl776 291 5 touched touch VBN cord-300061-l2pfl776 291 6 in in IN cord-300061-l2pfl776 291 7 the the DT cord-300061-l2pfl776 291 8 review review NN cord-300061-l2pfl776 291 9 report report NN cord-300061-l2pfl776 291 10 , , , cord-300061-l2pfl776 291 11 and and CC cord-300061-l2pfl776 291 12 I -PRON- PRP cord-300061-l2pfl776 291 13 therefore therefore RB cord-300061-l2pfl776 291 14 presume presume VBP cord-300061-l2pfl776 291 15 the the DT cord-300061-l2pfl776 291 16 reviewer reviewer NN cord-300061-l2pfl776 291 17 has have VBZ cord-300061-l2pfl776 291 18 no no DT cord-300061-l2pfl776 291 19 objection objection NN cord-300061-l2pfl776 291 20 to to IN cord-300061-l2pfl776 291 21 my -PRON- PRP$ cord-300061-l2pfl776 291 22 rebuttal rebuttal NN cord-300061-l2pfl776 291 23 . . . cord-300061-l2pfl776 292 1 The the DT cord-300061-l2pfl776 292 2 reviewer reviewer NN cord-300061-l2pfl776 292 3 , , , cord-300061-l2pfl776 292 4 however however RB cord-300061-l2pfl776 292 5 , , , cord-300061-l2pfl776 292 6 does do VBZ cord-300061-l2pfl776 292 7 disagree disagree VB cord-300061-l2pfl776 292 8 with with IN cord-300061-l2pfl776 292 9 my -PRON- PRP$ cord-300061-l2pfl776 292 10 rebuttal rebuttal NN cord-300061-l2pfl776 292 11 but but CC cord-300061-l2pfl776 292 12 agree agree VBP cord-300061-l2pfl776 292 13 with with IN cord-300061-l2pfl776 292 14 Elhaik Elhaik NNP cord-300061-l2pfl776 292 15 et et NNP cord-300061-l2pfl776 292 16 al al NNP cord-300061-l2pfl776 292 17 . . . cord-300061-l2pfl776 293 1 on on IN cord-300061-l2pfl776 293 2 some some DT cord-300061-l2pfl776 293 3 issues issue NNS cord-300061-l2pfl776 293 4 , , , cord-300061-l2pfl776 293 5 to to TO cord-300061-l2pfl776 293 6 which which WDT cord-300061-l2pfl776 293 7 I -PRON- PRP cord-300061-l2pfl776 293 8 will will MD cord-300061-l2pfl776 293 9 respond respond VB cord-300061-l2pfl776 293 10 point point NN cord-300061-l2pfl776 293 11 by by IN cord-300061-l2pfl776 293 12 point point NN cord-300061-l2pfl776 293 13 . . . cord-300061-l2pfl776 294 1 I -PRON- PRP cord-300061-l2pfl776 294 2 am be VBP cord-300061-l2pfl776 294 3 amazed amazed JJ cord-300061-l2pfl776 294 4 that that IN cord-300061-l2pfl776 294 5 so so RB cord-300061-l2pfl776 294 6 much much JJ cord-300061-l2pfl776 294 7 debate debate NN cord-300061-l2pfl776 294 8 can can MD cord-300061-l2pfl776 294 9 arise arise VB cord-300061-l2pfl776 294 10 over over IN cord-300061-l2pfl776 294 11 issues issue NNS cord-300061-l2pfl776 294 12 that that WDT cord-300061-l2pfl776 294 13 are be VBP cord-300061-l2pfl776 294 14 essentially essentially RB cord-300061-l2pfl776 294 15 very very RB cord-300061-l2pfl776 294 16 basic basic JJ cord-300061-l2pfl776 295 1 It -PRON- PRP cord-300061-l2pfl776 295 2 is be VBZ cord-300061-l2pfl776 295 3 not not RB cord-300061-l2pfl776 295 4 ' ' `` cord-300061-l2pfl776 295 5 surprising surprising JJ cord-300061-l2pfl776 295 6 ' ' '' cord-300061-l2pfl776 295 7 at at RB cord-300061-l2pfl776 295 8 all all RB cord-300061-l2pfl776 295 9 that that WDT cord-300061-l2pfl776 295 10 there there RB cord-300061-l2pfl776 295 11 that that WDT cord-300061-l2pfl776 295 12 one one NN cord-300061-l2pfl776 295 13 does do VBZ cord-300061-l2pfl776 295 14 not not RB cord-300061-l2pfl776 295 15 find find VB cord-300061-l2pfl776 295 16 genomes genome NNS cord-300061-l2pfl776 295 17 with with IN cord-300061-l2pfl776 295 18 large large JJ cord-300061-l2pfl776 295 19 S s NN cord-300061-l2pfl776 295 20 values value NNS cord-300061-l2pfl776 295 21 I -PRON- PRP cord-300061-l2pfl776 295 22 am be VBP cord-300061-l2pfl776 295 23 wondering wonder VBG cord-300061-l2pfl776 295 24 how how WRB cord-300061-l2pfl776 295 25 useful useful JJ cord-300061-l2pfl776 295 26 these these DT cord-300061-l2pfl776 295 27 kinds kind NNS cord-300061-l2pfl776 295 28 of of IN cord-300061-l2pfl776 295 29 exchanges exchange NNS cord-300061-l2pfl776 295 30 are be VBP cord-300061-l2pfl776 295 31 The the DT cord-300061-l2pfl776 295 32 discussion discussion NN cord-300061-l2pfl776 295 33 about about IN cord-300061-l2pfl776 295 34 Renyi Renyi NNP cord-300061-l2pfl776 295 35 entropies entropy NNS cord-300061-l2pfl776 295 36 is be VBZ cord-300061-l2pfl776 295 37 useless useless JJ cord-300061-l2pfl776 295 38 Author Author NNP cord-300061-l2pfl776 295 39 's 's POS cord-300061-l2pfl776 295 40 response response NN cord-300061-l2pfl776 296 1 I -PRON- PRP cord-300061-l2pfl776 296 2 agree agree VBP cord-300061-l2pfl776 296 3 that that IN cord-300061-l2pfl776 296 4 some some DT cord-300061-l2pfl776 296 5 issues issue NNS cord-300061-l2pfl776 296 6 are be VBP cord-300061-l2pfl776 296 7 basic basic JJ cord-300061-l2pfl776 296 8 . . . cord-300061-l2pfl776 297 1 For for IN cord-300061-l2pfl776 297 2 instance instance NN cord-300061-l2pfl776 297 3 , , , cord-300061-l2pfl776 297 4 their -PRON- PRP$ cord-300061-l2pfl776 297 5 first first JJ cord-300061-l2pfl776 297 6 claim claim NN cord-300061-l2pfl776 297 7 is be VBZ cord-300061-l2pfl776 297 8 due due JJ cord-300061-l2pfl776 297 9 to to TO cord-300061-l2pfl776 297 10 mistakenly mistakenly RB cord-300061-l2pfl776 297 11 neglecting neglect VBG cord-300061-l2pfl776 297 12 a a DT cord-300061-l2pfl776 297 13 parameter parameter NN cord-300061-l2pfl776 297 14 in in IN cord-300061-l2pfl776 297 15 coordinate coordinate JJ cord-300061-l2pfl776 297 16 transformation transformation NN cord-300061-l2pfl776 297 17 , , , cord-300061-l2pfl776 297 18 which which WDT cord-300061-l2pfl776 297 19 belongs belong VBZ cord-300061-l2pfl776 297 20 to to IN cord-300061-l2pfl776 297 21 elementary elementary JJ cord-300061-l2pfl776 297 22 mathematics mathematic NNS cord-300061-l2pfl776 297 23 . . . cord-300061-l2pfl776 298 1 However however RB cord-300061-l2pfl776 298 2 , , , cord-300061-l2pfl776 298 3 first first RB cord-300061-l2pfl776 298 4 , , , cord-300061-l2pfl776 298 5 here here RB cord-300061-l2pfl776 298 6 the the DT cord-300061-l2pfl776 298 7 issue issue NN cord-300061-l2pfl776 298 8 is be VBZ cord-300061-l2pfl776 298 9 not not RB cord-300061-l2pfl776 298 10 about about IN cord-300061-l2pfl776 298 11 whether whether IN cord-300061-l2pfl776 298 12 a a DT cord-300061-l2pfl776 298 13 topic topic NN cord-300061-l2pfl776 298 14 is be VBZ cord-300061-l2pfl776 298 15 basic basic JJ cord-300061-l2pfl776 298 16 or or CC cord-300061-l2pfl776 298 17 not not RB cord-300061-l2pfl776 298 18 , , , cord-300061-l2pfl776 298 19 surprising surprising JJ cord-300061-l2pfl776 298 20 or or CC cord-300061-l2pfl776 298 21 not not RB cord-300061-l2pfl776 298 22 , , , cord-300061-l2pfl776 298 23 useful useful JJ cord-300061-l2pfl776 298 24 or or CC cord-300061-l2pfl776 298 25 not not RB cord-300061-l2pfl776 298 26 ; ; : cord-300061-l2pfl776 298 27 it -PRON- PRP cord-300061-l2pfl776 298 28 is be VBZ cord-300061-l2pfl776 298 29 about about RB cord-300061-l2pfl776 298 30 right right JJ cord-300061-l2pfl776 298 31 or or CC cord-300061-l2pfl776 298 32 wrong wrong JJ cord-300061-l2pfl776 298 33 . . . cord-300061-l2pfl776 299 1 Regarding regard VBG cord-300061-l2pfl776 299 2 the the DT cord-300061-l2pfl776 299 3 questions question NNS cord-300061-l2pfl776 299 4 such such JJ cord-300061-l2pfl776 299 5 as as IN cord-300061-l2pfl776 299 6 whether whether IN cord-300061-l2pfl776 299 7 the the DT cord-300061-l2pfl776 299 8 calculation calculation NN cord-300061-l2pfl776 299 9 of of IN cord-300061-l2pfl776 299 10 the the DT cord-300061-l2pfl776 299 11 inscribed inscribe VBN cord-300061-l2pfl776 299 12 sphere sphere JJ cord-300061-l2pfl776 299 13 radius radius NN cord-300061-l2pfl776 299 14 is be VBZ cord-300061-l2pfl776 299 15 ' ' '' cord-300061-l2pfl776 299 16 a a DT cord-300061-l2pfl776 299 17 mathematical mathematical JJ cord-300061-l2pfl776 299 18 error error NN cord-300061-l2pfl776 299 19 ' ' '' cord-300061-l2pfl776 299 20 , , , cord-300061-l2pfl776 299 21 and and CC cord-300061-l2pfl776 299 22 whether whether IN cord-300061-l2pfl776 299 23 Z z NN cord-300061-l2pfl776 299 24 - - HYPH cord-300061-l2pfl776 299 25 curve curve NN cord-300061-l2pfl776 299 26 suffers suffer VBZ cord-300061-l2pfl776 299 27 from from IN cord-300061-l2pfl776 299 28 ' ' '' cord-300061-l2pfl776 299 29 over over IN cord-300061-l2pfl776 299 30 dimensionality dimensionality NN cord-300061-l2pfl776 299 31 ' ' '' cord-300061-l2pfl776 299 32 , , , cord-300061-l2pfl776 299 33 there there EX cord-300061-l2pfl776 299 34 is be VBZ cord-300061-l2pfl776 299 35 only only RB cord-300061-l2pfl776 299 36 one one CD cord-300061-l2pfl776 299 37 answer answer NN cord-300061-l2pfl776 299 38 : : : cord-300061-l2pfl776 300 1 yes yes UH cord-300061-l2pfl776 300 2 or or CC cord-300061-l2pfl776 300 3 no no UH cord-300061-l2pfl776 300 4 . . . cord-300061-l2pfl776 301 1 Science science NN cord-300061-l2pfl776 301 2 literatures literature NNS cord-300061-l2pfl776 301 3 and and CC cord-300061-l2pfl776 301 4 readers reader NNS cord-300061-l2pfl776 301 5 deserve deserve VBP cord-300061-l2pfl776 301 6 the the DT cord-300061-l2pfl776 301 7 truth truth NN cord-300061-l2pfl776 301 8 . . . cord-300061-l2pfl776 302 1 Second second RB cord-300061-l2pfl776 302 2 , , , cord-300061-l2pfl776 302 3 in in IN cord-300061-l2pfl776 302 4 contrast contrast NN cord-300061-l2pfl776 302 5 , , , cord-300061-l2pfl776 302 6 whether whether IN cord-300061-l2pfl776 302 7 a a DT cord-300061-l2pfl776 302 8 topic topic NN cord-300061-l2pfl776 302 9 is be VBZ cord-300061-l2pfl776 302 10 surprising surprising JJ cord-300061-l2pfl776 302 11 or or CC cord-300061-l2pfl776 302 12 useful useful JJ cord-300061-l2pfl776 302 13 is be VBZ cord-300061-l2pfl776 302 14 largely largely RB cord-300061-l2pfl776 302 15 a a DT cord-300061-l2pfl776 302 16 personal personal JJ cord-300061-l2pfl776 302 17 opinion opinion NN cord-300061-l2pfl776 302 18 . . . cord-300061-l2pfl776 303 1 Therefore therefore RB cord-300061-l2pfl776 303 2 I -PRON- PRP cord-300061-l2pfl776 303 3 will will MD cord-300061-l2pfl776 303 4 not not RB cord-300061-l2pfl776 303 5 further further RB cord-300061-l2pfl776 303 6 discuss discuss VB cord-300061-l2pfl776 303 7 whether whether IN cord-300061-l2pfl776 303 8 certain certain JJ cord-300061-l2pfl776 303 9 issues issue NNS cord-300061-l2pfl776 303 10 are be VBP cord-300061-l2pfl776 303 11 basic basic JJ cord-300061-l2pfl776 303 12 / / : cord-300061-l2pfl776 303 13 surprising surprising JJ cord-300061-l2pfl776 303 14 / / , cord-300061-l2pfl776 303 15 useful useful JJ cord-300061-l2pfl776 303 16 . . . cord-300061-l2pfl776 304 1 A a DT cord-300061-l2pfl776 304 2 second second JJ cord-300061-l2pfl776 304 3 point point NN cord-300061-l2pfl776 304 4 of of IN cord-300061-l2pfl776 304 5 contention contention NN cord-300061-l2pfl776 304 6 is be VBZ cord-300061-l2pfl776 304 7 whether whether IN cord-300061-l2pfl776 304 8 the the DT cord-300061-l2pfl776 304 9 S S NNP cord-300061-l2pfl776 304 10 statistic statistic NN cord-300061-l2pfl776 304 11 and and CC cord-300061-l2pfl776 304 12 the the DT cord-300061-l2pfl776 304 13 entropy entropy NN cord-300061-l2pfl776 304 14 H h NN cord-300061-l2pfl776 304 15 = = NN cord-300061-l2pfl776 304 16 -sum_x -sum_x : cord-300061-l2pfl776 304 17 f_x f_x CD cord-300061-l2pfl776 304 18 log(f_x log(f_x ADD cord-300061-l2pfl776 304 19 ) ) -RRB- cord-300061-l2pfl776 304 20 are be VBP cord-300061-l2pfl776 304 21 ' ' `` cord-300061-l2pfl776 304 22 equivalent equivalent JJ cord-300061-l2pfl776 304 23 ' ' '' cord-300061-l2pfl776 304 24 . . . cord-300061-l2pfl776 305 1 The the DT cord-300061-l2pfl776 305 2 dispute dispute NN cord-300061-l2pfl776 305 3 here here RB cord-300061-l2pfl776 305 4 seems seem VBZ cord-300061-l2pfl776 305 5 to to TO cord-300061-l2pfl776 305 6 mostly mostly RB cord-300061-l2pfl776 305 7 be be VB cord-300061-l2pfl776 305 8 of of IN cord-300061-l2pfl776 305 9 a a DT cord-300061-l2pfl776 305 10 semantic semantic JJ cord-300061-l2pfl776 305 11 nature nature NN cord-300061-l2pfl776 305 12 , , , cord-300061-l2pfl776 305 13 i.e. i.e. FW cord-300061-l2pfl776 305 14 regarding regard VBG cord-300061-l2pfl776 305 15 the the DT cord-300061-l2pfl776 305 16 meaning meaning NN cord-300061-l2pfl776 305 17 of of IN cord-300061-l2pfl776 305 18 the the DT cord-300061-l2pfl776 305 19 word word NN cord-300061-l2pfl776 305 20 ' ' `` cord-300061-l2pfl776 305 21 equivalent equivalent JJ cord-300061-l2pfl776 305 22 ' ' '' cord-300061-l2pfl776 305 23 . . . cord-300061-l2pfl776 306 1 I -PRON- PRP cord-300061-l2pfl776 306 2 can can MD cord-300061-l2pfl776 306 3 only only RB cord-300061-l2pfl776 306 4 see see VB cord-300061-l2pfl776 306 5 two two CD cord-300061-l2pfl776 306 6 relevant relevant JJ cord-300061-l2pfl776 306 7 points point NNS cord-300061-l2pfl776 306 8 : : : cord-300061-l2pfl776 306 9 1 1 LS cord-300061-l2pfl776 306 10 ) ) -RRB- cord-300061-l2pfl776 307 1 For for IN cord-300061-l2pfl776 307 2 large large JJ cord-300061-l2pfl776 307 3 DNA dna NN cord-300061-l2pfl776 307 4 sequences sequence NNS cord-300061-l2pfl776 307 5 ( ( -LRB- cord-300061-l2pfl776 307 6 like like IN cord-300061-l2pfl776 307 7 whole whole JJ cord-300061-l2pfl776 307 8 genomes genome NNS cord-300061-l2pfl776 307 9 ) ) -RRB- cord-300061-l2pfl776 307 10 it -PRON- PRP cord-300061-l2pfl776 307 11 is be VBZ cord-300061-l2pfl776 307 12 observed observe VBN cord-300061-l2pfl776 307 13 that that IN cord-300061-l2pfl776 307 14 there there EX cord-300061-l2pfl776 307 15 is be VBZ cord-300061-l2pfl776 307 16 an an DT cord-300061-l2pfl776 307 17 approximate approximate JJ cord-300061-l2pfl776 307 18 symmetry symmetry NN cord-300061-l2pfl776 307 19 between between IN cord-300061-l2pfl776 307 20 the the DT cord-300061-l2pfl776 307 21 two two CD cord-300061-l2pfl776 307 22 DNA dna NN cord-300061-l2pfl776 307 23 strands strand NNS cord-300061-l2pfl776 307 24 , , , cord-300061-l2pfl776 307 25 i.e. i.e. FW cord-300061-l2pfl776 307 26 the the DT cord-300061-l2pfl776 307 27 base base NN cord-300061-l2pfl776 307 28 composition composition NN cord-300061-l2pfl776 307 29 in in IN cord-300061-l2pfl776 307 30 one one CD cord-300061-l2pfl776 307 31 strand strand NN cord-300061-l2pfl776 307 32 is be VBZ cord-300061-l2pfl776 307 33 not not RB cord-300061-l2pfl776 307 34 significantly significantly RB cord-300061-l2pfl776 307 35 different different JJ cord-300061-l2pfl776 307 36 from from IN cord-300061-l2pfl776 307 37 the the DT cord-300061-l2pfl776 307 38 base base NN cord-300061-l2pfl776 307 39 composition composition NN cord-300061-l2pfl776 307 40 in in IN cord-300061-l2pfl776 307 41 the the DT cord-300061-l2pfl776 307 42 other other JJ cord-300061-l2pfl776 307 43 strand strand NN cord-300061-l2pfl776 307 44 . . . cord-300061-l2pfl776 308 1 Since since IN cord-300061-l2pfl776 308 2 , , , cord-300061-l2pfl776 308 3 by by IN cord-300061-l2pfl776 308 4 Watson Watson NNP cord-300061-l2pfl776 308 5 - - HYPH cord-300061-l2pfl776 308 6 Crick Crick NNP cord-300061-l2pfl776 308 7 base base NN cord-300061-l2pfl776 308 8 - - HYPH cord-300061-l2pfl776 308 9 pairing pair VBG cord-300061-l2pfl776 308 10 rules rule NNS cord-300061-l2pfl776 308 11 , , , cord-300061-l2pfl776 308 12 we -PRON- PRP cord-300061-l2pfl776 308 13 only only RB cord-300061-l2pfl776 308 14 have have VBP cord-300061-l2pfl776 308 15 C C NNP cord-300061-l2pfl776 308 16 - - HYPH cord-300061-l2pfl776 308 17 G G NNP cord-300061-l2pfl776 308 18 / / SYM cord-300061-l2pfl776 308 19 G G NNP cord-300061-l2pfl776 308 20 - - HYPH cord-300061-l2pfl776 308 21 C C NNP cord-300061-l2pfl776 308 22 and and CC cord-300061-l2pfl776 308 23 A a NN cord-300061-l2pfl776 309 1 -T -T : cord-300061-l2pfl776 309 2 / / SYM cord-300061-l2pfl776 309 3 T T NNP cord-300061-l2pfl776 309 4 - - HYPH cord-300061-l2pfl776 309 5 A A NNP cord-300061-l2pfl776 309 6 pairs pair NNS cord-300061-l2pfl776 309 7 , , , cord-300061-l2pfl776 309 8 this this DT cord-300061-l2pfl776 309 9 implies imply VBZ cord-300061-l2pfl776 309 10 that that IN cord-300061-l2pfl776 309 11 APPROXIMATELY approximately JJ cord-300061-l2pfl776 309 12 f_a f_a NN cord-300061-l2pfl776 309 13 = = SYM cord-300061-l2pfl776 309 14 f_t f_t NN cord-300061-l2pfl776 309 15 and and CC cord-300061-l2pfl776 309 16 f_c f_c NN cord-300061-l2pfl776 309 17 = = SYM cord-300061-l2pfl776 309 18 f_g f_g NN cord-300061-l2pfl776 309 19 ( ( -LRB- cord-300061-l2pfl776 309 20 * * NFP cord-300061-l2pfl776 309 21 ) ) -RRB- cord-300061-l2pfl776 309 22 Now now RB cord-300061-l2pfl776 309 23 , , , cord-300061-l2pfl776 309 24 if if IN cord-300061-l2pfl776 309 25 we -PRON- PRP cord-300061-l2pfl776 309 26 assume assume VBP cord-300061-l2pfl776 309 27 that that IN cord-300061-l2pfl776 309 28 the the DT cord-300061-l2pfl776 309 29 equalities equality NNS cord-300061-l2pfl776 309 30 ( ( -LRB- cord-300061-l2pfl776 309 31 * * NFP cord-300061-l2pfl776 309 32 ) ) -RRB- cord-300061-l2pfl776 309 33 hold hold VB cord-300061-l2pfl776 309 34 exactly exactly RB cord-300061-l2pfl776 309 35 , , , cord-300061-l2pfl776 309 36 then then RB cord-300061-l2pfl776 309 37 we -PRON- PRP cord-300061-l2pfl776 309 38 have have VBP cord-300061-l2pfl776 309 39 three three CD cord-300061-l2pfl776 309 40 constraints constraint NNS cord-300061-l2pfl776 310 1 f_a+f_c+f_g+f_t f_a+f_c+f_g+f_t NNP cord-300061-l2pfl776 310 2 = = SYM cord-300061-l2pfl776 310 3 1 1 CD cord-300061-l2pfl776 310 4 f_a f_a CD cord-300061-l2pfl776 310 5 = = SYM cord-300061-l2pfl776 310 6 f_t f_t NNP cord-300061-l2pfl776 310 7 f_c f_c NN cord-300061-l2pfl776 310 8 = = SYM cord-300061-l2pfl776 310 9 f_g f_g NN cord-300061-l2pfl776 311 1 and and CC cord-300061-l2pfl776 311 2 so so RB cord-300061-l2pfl776 311 3 we -PRON- PRP cord-300061-l2pfl776 311 4 effectively effectively RB cord-300061-l2pfl776 311 5 have have VBP cord-300061-l2pfl776 311 6 only only RB cord-300061-l2pfl776 311 7 1 1 CD cord-300061-l2pfl776 311 8 degree degree NN cord-300061-l2pfl776 311 9 of of IN cord-300061-l2pfl776 311 10 freedom freedom NN cord-300061-l2pfl776 311 11 left leave VBN cord-300061-l2pfl776 311 12 ( ( -LRB- cord-300061-l2pfl776 311 13 which which WDT cord-300061-l2pfl776 311 14 is be VBZ cord-300061-l2pfl776 311 15 essentially essentially RB cord-300061-l2pfl776 311 16 GC gc NN cord-300061-l2pfl776 311 17 - - HYPH cord-300061-l2pfl776 311 18 content content NN cord-300061-l2pfl776 311 19 ) ) -RRB- cord-300061-l2pfl776 311 20 . . . cord-300061-l2pfl776 312 1 Since since IN cord-300061-l2pfl776 312 2 both both DT cord-300061-l2pfl776 312 3 S S NNP cord-300061-l2pfl776 312 4 and and CC cord-300061-l2pfl776 312 5 H H NNP cord-300061-l2pfl776 312 6 are be VBP cord-300061-l2pfl776 312 7 invertible invertible JJ cord-300061-l2pfl776 312 8 functions function NNS cord-300061-l2pfl776 312 9 of of IN cord-300061-l2pfl776 312 10 the the DT cord-300061-l2pfl776 312 11 remaining remain VBG cord-300061-l2pfl776 312 12 degree degree NN cord-300061-l2pfl776 312 13 of of IN cord-300061-l2pfl776 312 14 freedom freedom NN cord-300061-l2pfl776 312 15 , , , cord-300061-l2pfl776 312 16 it -PRON- PRP cord-300061-l2pfl776 312 17 immediately immediately RB cord-300061-l2pfl776 312 18 follows follow VBZ cord-300061-l2pfl776 312 19 that that IN cord-300061-l2pfl776 312 20 S S NNP cord-300061-l2pfl776 312 21 can can MD cord-300061-l2pfl776 312 22 be be VB cord-300061-l2pfl776 312 23 calculated calculate VBN cord-300061-l2pfl776 312 24 from from IN cord-300061-l2pfl776 312 25 H H NNP cord-300061-l2pfl776 312 26 and and CC cord-300061-l2pfl776 312 27 H H NNP cord-300061-l2pfl776 312 28 from from IN cord-300061-l2pfl776 312 29 S. S. NNP cord-300061-l2pfl776 313 1 Whether whether IN cord-300061-l2pfl776 313 2 you -PRON- PRP cord-300061-l2pfl776 313 3 want want VBP cord-300061-l2pfl776 313 4 to to TO cord-300061-l2pfl776 313 5 call call VB cord-300061-l2pfl776 313 6 this this DT cord-300061-l2pfl776 313 7 equivalent equivalent NN cord-300061-l2pfl776 313 8 or or CC cord-300061-l2pfl776 313 9 not not RB cord-300061-l2pfl776 313 10 is be VBZ cord-300061-l2pfl776 313 11 a a DT cord-300061-l2pfl776 313 12 matter matter NN cord-300061-l2pfl776 313 13 of of IN cord-300061-l2pfl776 313 14 semantics semantic NNS cord-300061-l2pfl776 313 15 . . . cord-300061-l2pfl776 314 1 The the DT cord-300061-l2pfl776 314 2 point point NN cord-300061-l2pfl776 314 3 is be VBZ cord-300061-l2pfl776 314 4 that that IN cord-300061-l2pfl776 314 5 when when WRB cord-300061-l2pfl776 314 6 all all DT cord-300061-l2pfl776 314 7 three three CD cord-300061-l2pfl776 314 8 constrains constrain NNS cord-300061-l2pfl776 314 9 are be VBP cord-300061-l2pfl776 314 10 acting act VBG cord-300061-l2pfl776 314 11 , , , cord-300061-l2pfl776 314 12 there there EX cord-300061-l2pfl776 314 13 is be VBZ cord-300061-l2pfl776 314 14 only only RB cord-300061-l2pfl776 314 15 one one CD cord-300061-l2pfl776 314 16 degree degree NN cord-300061-l2pfl776 314 17 of of IN cord-300061-l2pfl776 314 18 freedom freedom NN cord-300061-l2pfl776 314 19 left leave VBN cord-300061-l2pfl776 314 20 . . . cord-300061-l2pfl776 315 1 Instead instead RB cord-300061-l2pfl776 315 2 of of IN cord-300061-l2pfl776 315 3 calculating calculate VBG cord-300061-l2pfl776 315 4 S S NNP cord-300061-l2pfl776 315 5 or or CC cord-300061-l2pfl776 315 6 H H NNP cord-300061-l2pfl776 315 7 , , , cord-300061-l2pfl776 315 8 I -PRON- PRP cord-300061-l2pfl776 315 9 think think VBP cord-300061-l2pfl776 315 10 it -PRON- PRP cord-300061-l2pfl776 315 11 would would MD cord-300061-l2pfl776 315 12 be be VB cord-300061-l2pfl776 315 13 much much RB cord-300061-l2pfl776 315 14 more more RBR cord-300061-l2pfl776 315 15 straight straight RB cord-300061-l2pfl776 315 16 - - HYPH cord-300061-l2pfl776 315 17 forward forward NN cord-300061-l2pfl776 315 18 to to IN cord-300061-l2pfl776 315 19 just just RB cord-300061-l2pfl776 315 20 talk talk VB cord-300061-l2pfl776 315 21 about about IN cord-300061-l2pfl776 315 22 GC gc NN cord-300061-l2pfl776 315 23 - - HYPH cord-300061-l2pfl776 315 24 content content NN cord-300061-l2pfl776 315 25 directly directly RB cord-300061-l2pfl776 315 26 . . . cord-300061-l2pfl776 316 1 Indeed indeed RB cord-300061-l2pfl776 316 2 , , , cord-300061-l2pfl776 316 3 it -PRON- PRP cord-300061-l2pfl776 316 4 is be VBZ cord-300061-l2pfl776 316 5 remarkable remarkable JJ cord-300061-l2pfl776 316 6 that that IN cord-300061-l2pfl776 316 7 CG cg NN cord-300061-l2pfl776 316 8 - - HYPH cord-300061-l2pfl776 316 9 content content NN cord-300061-l2pfl776 316 10 ranges range NNS cord-300061-l2pfl776 316 11 from from IN cord-300061-l2pfl776 316 12 as as RB cord-300061-l2pfl776 316 13 low low JJ cord-300061-l2pfl776 316 14 as as IN cord-300061-l2pfl776 316 15 0.22 0.22 CD cord-300061-l2pfl776 316 16 to to IN cord-300061-l2pfl776 316 17 as as RB cord-300061-l2pfl776 316 18 high high JJ cord-300061-l2pfl776 316 19 as as IN cord-300061-l2pfl776 316 20 0.77 0.77 CD cord-300061-l2pfl776 316 21 and and CC cord-300061-l2pfl776 316 22 the the DT cord-300061-l2pfl776 316 23 relevant relevant JJ cord-300061-l2pfl776 316 24 biological biological JJ cord-300061-l2pfl776 316 25 question question NN cord-300061-l2pfl776 316 26 , , , cord-300061-l2pfl776 316 27 in in IN cord-300061-l2pfl776 316 28 my -PRON- PRP$ cord-300061-l2pfl776 316 29 opinion opinion NN cord-300061-l2pfl776 316 30 , , , cord-300061-l2pfl776 316 31 is be VBZ cord-300061-l2pfl776 316 32 not not RB cord-300061-l2pfl776 316 33 whether whether IN cord-300061-l2pfl776 316 34 to to TO cord-300061-l2pfl776 316 35 use use VB cord-300061-l2pfl776 316 36 S S NNP cord-300061-l2pfl776 316 37 or or CC cord-300061-l2pfl776 316 38 H H NNP cord-300061-l2pfl776 316 39 or or CC cord-300061-l2pfl776 316 40 whatever whatever WDT cord-300061-l2pfl776 316 41 other other JJ cord-300061-l2pfl776 316 42 derived derive VBN cord-300061-l2pfl776 316 43 statistic statistic NN cord-300061-l2pfl776 316 44 , , , cord-300061-l2pfl776 316 45 but but CC cord-300061-l2pfl776 316 46 rather rather RB cord-300061-l2pfl776 316 47 trying try VBG cord-300061-l2pfl776 316 48 to to TO cord-300061-l2pfl776 316 49 explain explain VB cord-300061-l2pfl776 316 50 why why WRB cord-300061-l2pfl776 316 51 GC gc NN cord-300061-l2pfl776 316 52 - - HYPH cord-300061-l2pfl776 316 53 content content NN cord-300061-l2pfl776 316 54 varies vary VBZ cord-300061-l2pfl776 316 55 so so RB cord-300061-l2pfl776 316 56 much much RB cord-300061-l2pfl776 316 57 in in IN cord-300061-l2pfl776 316 58 bacterial bacterial JJ cord-300061-l2pfl776 316 59 genomes genome NNS cord-300061-l2pfl776 316 60 . . . cord-300061-l2pfl776 317 1 Indeed indeed RB cord-300061-l2pfl776 317 2 there there EX cord-300061-l2pfl776 317 3 has have VBZ cord-300061-l2pfl776 317 4 been be VBN cord-300061-l2pfl776 317 5 quite quite RB cord-300061-l2pfl776 317 6 some some DT cord-300061-l2pfl776 317 7 interesting interesting JJ cord-300061-l2pfl776 317 8 developments development NNS cord-300061-l2pfl776 317 9 in in IN cord-300061-l2pfl776 317 10 this this DT cord-300061-l2pfl776 317 11 area area NN cord-300061-l2pfl776 317 12 recently recently RB cord-300061-l2pfl776 317 13 . . . cord-300061-l2pfl776 318 1 See see VB cord-300061-l2pfl776 318 2 for for IN cord-300061-l2pfl776 318 3 example example NN cord-300061-l2pfl776 318 4 the the DT cord-300061-l2pfl776 318 5 discussion discussion NN cord-300061-l2pfl776 318 6 in in IN cord-300061-l2pfl776 318 7 : : : cord-300061-l2pfl776 319 1 Rocha Rocha NNP cord-300061-l2pfl776 319 2 EP EP NNP cord-300061-l2pfl776 319 3 , , , cord-300061-l2pfl776 319 4 Feil Feil NNP cord-300061-l2pfl776 319 5 EJ EJ NNP cord-300061-l2pfl776 319 6 . . . cord-300061-l2pfl776 320 1 Mutational mutational JJ cord-300061-l2pfl776 320 2 patterns pattern NNS cord-300061-l2pfl776 320 3 can can MD cord-300061-l2pfl776 320 4 not not RB cord-300061-l2pfl776 320 5 explain explain VB cord-300061-l2pfl776 320 6 genome genome NN cord-300061-l2pfl776 320 7 composition composition NN cord-300061-l2pfl776 320 8 : : : cord-300061-l2pfl776 320 9 are be VBP cord-300061-l2pfl776 320 10 there there EX cord-300061-l2pfl776 320 11 any any DT cord-300061-l2pfl776 320 12 neutral neutral JJ cord-300061-l2pfl776 320 13 sites site NNS cord-300061-l2pfl776 320 14 in in IN cord-300061-l2pfl776 320 15 the the DT cord-300061-l2pfl776 320 16 genomes genome NNS cord-300061-l2pfl776 320 17 of of IN cord-300061-l2pfl776 320 18 bacteria bacteria NNS cord-300061-l2pfl776 320 19 ? ? . cord-300061-l2pfl776 321 1 PLoS PLoS NNP cord-300061-l2pfl776 321 2 Genet Genet NNP cord-300061-l2pfl776 321 3 . . . cord-300061-l2pfl776 322 1 2010 2010 CD cord-300061-l2pfl776 322 2 Sep Sep NNP cord-300061-l2pfl776 322 3 9;6(9 9;6(9 CD cord-300061-l2pfl776 322 4 ) ) -RRB- cord-300061-l2pfl776 322 5 . . . cord-300061-l2pfl776 323 1 The the DT cord-300061-l2pfl776 323 2 discussion discussion NN cord-300061-l2pfl776 323 3 about about IN cord-300061-l2pfl776 323 4 Renyi Renyi NNP cord-300061-l2pfl776 323 5 entropies entropy NNS cord-300061-l2pfl776 323 6 is be VBZ cord-300061-l2pfl776 323 7 useless useless JJ cord-300061-l2pfl776 323 8 in in IN cord-300061-l2pfl776 323 9 my -PRON- PRP$ cord-300061-l2pfl776 323 10 opinion opinion NN cord-300061-l2pfl776 323 11 . . . cord-300061-l2pfl776 324 1 Yes yes UH cord-300061-l2pfl776 324 2 , , , cord-300061-l2pfl776 324 3 both both CC cord-300061-l2pfl776 324 4 S S NNP cord-300061-l2pfl776 324 5 and and CC cord-300061-l2pfl776 324 6 H H NNP cord-300061-l2pfl776 324 7 are be VBP cord-300061-l2pfl776 324 8 both both DT cord-300061-l2pfl776 324 9 members member NNS cord-300061-l2pfl776 324 10 of of IN cord-300061-l2pfl776 324 11 a a DT cord-300061-l2pfl776 324 12 family family NN cord-300061-l2pfl776 324 13 of of IN cord-300061-l2pfl776 324 14 functions function NNS cord-300061-l2pfl776 324 15 ( ( -LRB- cord-300061-l2pfl776 324 16 Renyi Renyi NNP cord-300061-l2pfl776 324 17 entropies entropy NNS cord-300061-l2pfl776 324 18 ) ) -RRB- cord-300061-l2pfl776 324 19 but but CC cord-300061-l2pfl776 325 1 I -PRON- PRP cord-300061-l2pfl776 325 2 fail fail VBP cord-300061-l2pfl776 325 3 to to TO cord-300061-l2pfl776 325 4 see see VB cord-300061-l2pfl776 325 5 how how WRB cord-300061-l2pfl776 325 6 this this DT cord-300061-l2pfl776 325 7 is be VBZ cord-300061-l2pfl776 325 8 relevant relevant JJ cord-300061-l2pfl776 325 9 for for IN cord-300061-l2pfl776 325 10 any any DT cord-300061-l2pfl776 325 11 biological biological JJ cord-300061-l2pfl776 325 12 question question NN cord-300061-l2pfl776 325 13 . . . cord-300061-l2pfl776 326 1 Throughout throughout IN cord-300061-l2pfl776 326 2 the the DT cord-300061-l2pfl776 326 3 criticisms criticism NNS cord-300061-l2pfl776 326 4 and and CC cord-300061-l2pfl776 326 5 the the DT cord-300061-l2pfl776 326 6 rebuttal rebuttal NN cord-300061-l2pfl776 326 7 , , , cord-300061-l2pfl776 326 8 when when WRB cord-300061-l2pfl776 326 9 debating debate VBG cord-300061-l2pfl776 326 10 on on IN cord-300061-l2pfl776 326 11 S S NNP cord-300061-l2pfl776 326 12 and and CC cord-300061-l2pfl776 326 13 H H NNP cord-300061-l2pfl776 326 14 , , , cord-300061-l2pfl776 326 15 the the DT cord-300061-l2pfl776 326 16 only only JJ cord-300061-l2pfl776 326 17 Chargaff Chargaff NNP cord-300061-l2pfl776 326 18 Parity Parity NNP cord-300061-l2pfl776 326 19 Rule Rule NNP cord-300061-l2pfl776 326 20 being be VBG cord-300061-l2pfl776 326 21 referred refer VBN cord-300061-l2pfl776 326 22 to to IN cord-300061-l2pfl776 326 23 is be VBZ cord-300061-l2pfl776 326 24 the the DT cord-300061-l2pfl776 326 25 parity parity NN cord-300061-l2pfl776 326 26 rule rule NN cord-300061-l2pfl776 326 27 2 2 CD cord-300061-l2pfl776 326 28 ( ( -LRB- cord-300061-l2pfl776 326 29 PR2 PR2 NNP cord-300061-l2pfl776 326 30 ) ) -RRB- cord-300061-l2pfl776 326 31 . . . cord-300061-l2pfl776 327 1 Note note VB cord-300061-l2pfl776 327 2 that that IN cord-300061-l2pfl776 327 3 PR2 PR2 NNP cord-300061-l2pfl776 327 4 is be VBZ cord-300061-l2pfl776 327 5 a a DT cord-300061-l2pfl776 327 6 phenomenon phenomenon NN cord-300061-l2pfl776 327 7 in in IN cord-300061-l2pfl776 327 8 one one CD cord-300061-l2pfl776 327 9 single single JJ cord-300061-l2pfl776 327 10 DNA dna NN cord-300061-l2pfl776 327 11 strand strand NN cord-300061-l2pfl776 327 12 ( ( -LRB- cord-300061-l2pfl776 327 13 a~= a~= NNP cord-300061-l2pfl776 327 14 t t NNP cord-300061-l2pfl776 327 15 and and CC cord-300061-l2pfl776 327 16 c~= c~= NNP cord-300061-l2pfl776 327 17 g g NNP cord-300061-l2pfl776 327 18 ) ) -RRB- cord-300061-l2pfl776 327 19 , , , cord-300061-l2pfl776 327 20 but but CC cord-300061-l2pfl776 327 21 not not RB cord-300061-l2pfl776 327 22 double double JJ cord-300061-l2pfl776 327 23 DNA dna NN cord-300061-l2pfl776 327 24 strands strand NNS cord-300061-l2pfl776 327 25 . . . cord-300061-l2pfl776 328 1 Indeed indeed RB cord-300061-l2pfl776 328 2 , , , cord-300061-l2pfl776 328 3 in in IN cord-300061-l2pfl776 328 4 a a DT cord-300061-l2pfl776 328 5 duplex duplex JJ cord-300061-l2pfl776 328 6 DNA dna NN cord-300061-l2pfl776 328 7 , , , cord-300061-l2pfl776 328 8 a a NN cord-300061-l2pfl776 328 9 = = SYM cord-300061-l2pfl776 328 10 t t NN cord-300061-l2pfl776 328 11 and and CC cord-300061-l2pfl776 328 12 c c NN cord-300061-l2pfl776 328 13 = = SYM cord-300061-l2pfl776 328 14 g g NN cord-300061-l2pfl776 328 15 , , , cord-300061-l2pfl776 328 16 due due IN cord-300061-l2pfl776 328 17 to to IN cord-300061-l2pfl776 328 18 Watson Watson NNP cord-300061-l2pfl776 328 19 - - HYPH cord-300061-l2pfl776 328 20 Crick Crick NNP cord-300061-l2pfl776 328 21 base base NN cord-300061-l2pfl776 328 22 pairing pairing NN cord-300061-l2pfl776 328 23 , , , cord-300061-l2pfl776 328 24 but but CC cord-300061-l2pfl776 328 25 that that DT cord-300061-l2pfl776 328 26 is be VBZ cord-300061-l2pfl776 328 27 the the DT cord-300061-l2pfl776 328 28 Chargaff Chargaff NNP cord-300061-l2pfl776 328 29 Parity Parity NNP cord-300061-l2pfl776 328 30 Rule Rule NNP cord-300061-l2pfl776 328 31 1 1 CD cord-300061-l2pfl776 328 32 . . . cord-300061-l2pfl776 329 1 The the DT cord-300061-l2pfl776 329 2 reviewer reviewer NN cord-300061-l2pfl776 329 3 's 's POS cord-300061-l2pfl776 329 4 discussion discussion NN cord-300061-l2pfl776 329 5 is be VBZ cord-300061-l2pfl776 329 6 based base VBN cord-300061-l2pfl776 329 7 on on IN cord-300061-l2pfl776 329 8 the the DT cord-300061-l2pfl776 329 9 phenomenon phenomenon NN cord-300061-l2pfl776 329 10 in in IN cord-300061-l2pfl776 329 11 2 2 CD cord-300061-l2pfl776 329 12 DNA dna NN cord-300061-l2pfl776 329 13 strands strand NNS cord-300061-l2pfl776 329 14 . . . cord-300061-l2pfl776 330 1 The the DT cord-300061-l2pfl776 330 2 reviewer reviewer NN cord-300061-l2pfl776 330 3 writes write VBZ cord-300061-l2pfl776 330 4 : : : cord-300061-l2pfl776 330 5 " " `` cord-300061-l2pfl776 330 6 symmetry symmetry NN cord-300061-l2pfl776 330 7 between between IN cord-300061-l2pfl776 330 8 the the DT cord-300061-l2pfl776 330 9 two two CD cord-300061-l2pfl776 330 10 DNA dna NN cord-300061-l2pfl776 330 11 strands strand NNS cord-300061-l2pfl776 330 12 , , , cord-300061-l2pfl776 330 13 i.e. i.e. FW cord-300061-l2pfl776 330 14 the the DT cord-300061-l2pfl776 330 15 base base NN cord-300061-l2pfl776 330 16 composition composition NN cord-300061-l2pfl776 330 17 in in IN cord-300061-l2pfl776 330 18 one one CD cord-300061-l2pfl776 330 19 strand strand NN cord-300061-l2pfl776 330 20 is be VBZ cord-300061-l2pfl776 330 21 not not RB cord-300061-l2pfl776 330 22 significantly significantly RB cord-300061-l2pfl776 330 23 different different JJ cord-300061-l2pfl776 330 24 from from IN cord-300061-l2pfl776 330 25 the the DT cord-300061-l2pfl776 330 26 base base NN cord-300061-l2pfl776 330 27 composition composition NN cord-300061-l2pfl776 330 28 in in IN cord-300061-l2pfl776 330 29 the the DT cord-300061-l2pfl776 330 30 other other JJ cord-300061-l2pfl776 330 31 strand strand NN cord-300061-l2pfl776 330 32 ... ... . cord-300061-l2pfl776 331 1 Since since IN cord-300061-l2pfl776 331 2 by by IN cord-300061-l2pfl776 331 3 Watson Watson NNP cord-300061-l2pfl776 331 4 - - HYPH cord-300061-l2pfl776 331 5 Crick Crick NNP cord-300061-l2pfl776 331 6 base base NN cord-300061-l2pfl776 331 7 - - HYPH cord-300061-l2pfl776 331 8 pairing pair VBG cord-300061-l2pfl776 331 9 rules rule NNS cord-300061-l2pfl776 331 10 , , , cord-300061-l2pfl776 331 11 we -PRON- PRP cord-300061-l2pfl776 331 12 only only RB cord-300061-l2pfl776 331 13 have have VBP cord-300061-l2pfl776 331 14 C C NNP cord-300061-l2pfl776 331 15 - - HYPH cord-300061-l2pfl776 331 16 G G NNP cord-300061-l2pfl776 331 17 / / SYM cord-300061-l2pfl776 331 18 G G NNP cord-300061-l2pfl776 331 19 - - HYPH cord-300061-l2pfl776 331 20 C C NNP cord-300061-l2pfl776 331 21 and and CC cord-300061-l2pfl776 331 22 A a NN cord-300061-l2pfl776 332 1 -T -T : cord-300061-l2pfl776 332 2 / / SYM cord-300061-l2pfl776 332 3 T T NNP cord-300061-l2pfl776 332 4 - - HYPH cord-300061-l2pfl776 332 5 A A NNP cord-300061-l2pfl776 332 6 pairs pair NNS cord-300061-l2pfl776 332 7 ... ... : cord-300061-l2pfl776 332 8 " " '' cord-300061-l2pfl776 332 9 . . . cord-300061-l2pfl776 333 1 The the DT cord-300061-l2pfl776 333 2 debate debate NN cord-300061-l2pfl776 333 3 is be VBZ cord-300061-l2pfl776 333 4 about about IN cord-300061-l2pfl776 333 5 PR2 PR2 NNP cord-300061-l2pfl776 333 6 , , , cord-300061-l2pfl776 333 7 a a DT cord-300061-l2pfl776 333 8 phenomenon phenomenon NN cord-300061-l2pfl776 333 9 of of IN cord-300061-l2pfl776 333 10 base base NN cord-300061-l2pfl776 333 11 compositions composition NNS cord-300061-l2pfl776 333 12 in in IN cord-300061-l2pfl776 333 13 the the DT cord-300061-l2pfl776 333 14 DNA dna NN cord-300061-l2pfl776 333 15 single single JJ cord-300061-l2pfl776 333 16 strand strand NN cord-300061-l2pfl776 333 17 , , , cord-300061-l2pfl776 333 18 while while IN cord-300061-l2pfl776 333 19 the the DT cord-300061-l2pfl776 333 20 reviewer reviewer NN cord-300061-l2pfl776 333 21 's 's POS cord-300061-l2pfl776 333 22 discussion discussion NN cord-300061-l2pfl776 333 23 is be VBZ cord-300061-l2pfl776 333 24 about about IN cord-300061-l2pfl776 333 25 DNA dna NN cord-300061-l2pfl776 333 26 double double JJ cord-300061-l2pfl776 333 27 strands strand NNS cord-300061-l2pfl776 333 28 . . . cord-300061-l2pfl776 334 1 Because because IN cord-300061-l2pfl776 334 2 of of IN cord-300061-l2pfl776 334 3 this this DT cord-300061-l2pfl776 334 4 misunderstanding misunderstanding NN cord-300061-l2pfl776 334 5 , , , cord-300061-l2pfl776 334 6 the the DT cord-300061-l2pfl776 334 7 reviewer reviewer NN cord-300061-l2pfl776 334 8 's 's POS cord-300061-l2pfl776 334 9 discussion discussion NN cord-300061-l2pfl776 334 10 about about IN cord-300061-l2pfl776 334 11 S S NNP cord-300061-l2pfl776 334 12 and and CC cord-300061-l2pfl776 334 13 H H NNP cord-300061-l2pfl776 334 14 becomes become VBZ cord-300061-l2pfl776 334 15 almost almost RB cord-300061-l2pfl776 334 16 irrelevant irrelevant JJ cord-300061-l2pfl776 334 17 . . . cord-300061-l2pfl776 335 1 Thus thus RB cord-300061-l2pfl776 335 2 , , , cord-300061-l2pfl776 335 3 I -PRON- PRP cord-300061-l2pfl776 335 4 agree agree VBP cord-300061-l2pfl776 335 5 with with IN cord-300061-l2pfl776 335 6 Elhaik Elhaik NNP cord-300061-l2pfl776 335 7 et et NNP cord-300061-l2pfl776 335 8 al al NNP cord-300061-l2pfl776 335 9 . . . cord-300061-l2pfl776 336 1 that that IN cord-300061-l2pfl776 336 2 the the DT cord-300061-l2pfl776 336 3 variation variation NN cord-300061-l2pfl776 336 4 of of IN cord-300061-l2pfl776 336 5 S S NNP cord-300061-l2pfl776 336 6 and and CC cord-300061-l2pfl776 336 7 H H NNP cord-300061-l2pfl776 336 8 across across IN cord-300061-l2pfl776 336 9 different different JJ cord-300061-l2pfl776 336 10 genomes genome NNS cord-300061-l2pfl776 336 11 is be VBZ cord-300061-l2pfl776 336 12 dominated dominate VBN cord-300061-l2pfl776 336 13 by by IN cord-300061-l2pfl776 336 14 the the DT cord-300061-l2pfl776 336 15 variation variation NN cord-300061-l2pfl776 336 16 in in IN cord-300061-l2pfl776 336 17 GC gc NN cord-300061-l2pfl776 336 18 - - HYPH cord-300061-l2pfl776 336 19 content content NN cord-300061-l2pfl776 336 20 . . . cord-300061-l2pfl776 337 1 Here here RB cord-300061-l2pfl776 337 2 the the DT cord-300061-l2pfl776 337 3 reviewer reviewer NN cord-300061-l2pfl776 337 4 agrees agree VBZ cord-300061-l2pfl776 337 5 with with IN cord-300061-l2pfl776 337 6 Elhaik Elhaik NNP cord-300061-l2pfl776 337 7 et et NNP cord-300061-l2pfl776 337 8 al al NNP cord-300061-l2pfl776 337 9 . . . cord-300061-l2pfl776 338 1 for for IN cord-300061-l2pfl776 338 2 a a DT cord-300061-l2pfl776 338 3 point point NN cord-300061-l2pfl776 338 4 that that WDT cord-300061-l2pfl776 338 5 Elhaik Elhaik NNP cord-300061-l2pfl776 338 6 et et NNP cord-300061-l2pfl776 338 7 al al NNP cord-300061-l2pfl776 338 8 . . . cord-300061-l2pfl776 339 1 did do VBD cord-300061-l2pfl776 339 2 not not RB cord-300061-l2pfl776 339 3 intend intend VB cord-300061-l2pfl776 339 4 to to TO cord-300061-l2pfl776 339 5 make make VB cord-300061-l2pfl776 339 6 . . . cord-300061-l2pfl776 340 1 Elhaik Elhaik NNP cord-300061-l2pfl776 340 2 et et NNP cord-300061-l2pfl776 340 3 al al NNP cord-300061-l2pfl776 340 4 . . NNP cord-300061-l2pfl776 340 5 studied study VBD cord-300061-l2pfl776 340 6 the the DT cord-300061-l2pfl776 340 7 variations variation NNS cord-300061-l2pfl776 340 8 of of IN cord-300061-l2pfl776 340 9 Z z NN cord-300061-l2pfl776 340 10 - - HYPH cord-300061-l2pfl776 340 11 curve curve NN cord-300061-l2pfl776 340 12 's 's POS cord-300061-l2pfl776 340 13 3 3 CD cord-300061-l2pfl776 340 14 components component NNS cord-300061-l2pfl776 340 15 ( ( -LRB- cord-300061-l2pfl776 340 16 x x SYM cord-300061-l2pfl776 340 17 , , , cord-300061-l2pfl776 340 18 y y NNP cord-300061-l2pfl776 340 19 , , , cord-300061-l2pfl776 340 20 z z LS cord-300061-l2pfl776 340 21 ) ) -RRB- cord-300061-l2pfl776 340 22 using use VBG cord-300061-l2pfl776 340 23 235 235 CD cord-300061-l2pfl776 340 24 bacterial bacterial JJ cord-300061-l2pfl776 340 25 genomes genome NNS cord-300061-l2pfl776 340 26 , , , cord-300061-l2pfl776 340 27 and and CC cord-300061-l2pfl776 340 28 found find VBD cord-300061-l2pfl776 340 29 that that IN cord-300061-l2pfl776 340 30 the the DT cord-300061-l2pfl776 340 31 z z NNP cord-300061-l2pfl776 340 32 component component NN cord-300061-l2pfl776 340 33 ( ( -LRB- cord-300061-l2pfl776 340 34 which which WDT cord-300061-l2pfl776 340 35 is be VBZ cord-300061-l2pfl776 340 36 related relate VBN cord-300061-l2pfl776 340 37 to to IN cord-300061-l2pfl776 340 38 GC GC NNP cord-300061-l2pfl776 340 39 content content NN cord-300061-l2pfl776 340 40 ) ) -RRB- cord-300061-l2pfl776 340 41 contributed contribute VBD cord-300061-l2pfl776 340 42 to to IN cord-300061-l2pfl776 340 43 most most JJS cord-300061-l2pfl776 340 44 of of IN cord-300061-l2pfl776 340 45 the the DT cord-300061-l2pfl776 340 46 variance variance NN cord-300061-l2pfl776 340 47 , , , cord-300061-l2pfl776 340 48 comparing compare VBG cord-300061-l2pfl776 340 49 to to IN cord-300061-l2pfl776 340 50 x x SYM cord-300061-l2pfl776 340 51 and and CC cord-300061-l2pfl776 340 52 y y NNP cord-300061-l2pfl776 340 53 components component NNS cord-300061-l2pfl776 340 54 ( ( -LRB- cord-300061-l2pfl776 340 55 please please UH cord-300061-l2pfl776 340 56 refer refer VB cord-300061-l2pfl776 340 57 to to IN cord-300061-l2pfl776 340 58 the the DT cord-300061-l2pfl776 340 59 figure figure NN cord-300061-l2pfl776 340 60 4 4 CD cord-300061-l2pfl776 340 61 in in IN cord-300061-l2pfl776 340 62 ref ref NN cord-300061-l2pfl776 340 63 . . . cord-300061-l2pfl776 341 1 [ [ -LRB- cord-300061-l2pfl776 341 2 5 5 CD cord-300061-l2pfl776 341 3 ] ] -RRB- cord-300061-l2pfl776 341 4 ) ) -RRB- cord-300061-l2pfl776 341 5 . . . cord-300061-l2pfl776 342 1 Note note VB cord-300061-l2pfl776 342 2 that that IN cord-300061-l2pfl776 342 3 the the DT cord-300061-l2pfl776 342 4 studied study VBN cord-300061-l2pfl776 342 5 variations variation NNS cord-300061-l2pfl776 342 6 are be VBP cord-300061-l2pfl776 342 7 about about IN cord-300061-l2pfl776 342 8 Z z NN cord-300061-l2pfl776 342 9 - - HYPH cord-300061-l2pfl776 342 10 curve curve NN cord-300061-l2pfl776 342 11 , , , cord-300061-l2pfl776 342 12 not not RB cord-300061-l2pfl776 342 13 related relate VBN cord-300061-l2pfl776 342 14 to to IN cord-300061-l2pfl776 342 15 S S NNP cord-300061-l2pfl776 342 16 and and CC cord-300061-l2pfl776 342 17 H. h. NN cord-300061-l2pfl776 343 1 Nevertheless nevertheless RB cord-300061-l2pfl776 343 2 , , , cord-300061-l2pfl776 343 3 it -PRON- PRP cord-300061-l2pfl776 343 4 is be VBZ cord-300061-l2pfl776 343 5 true true JJ cord-300061-l2pfl776 343 6 that that IN cord-300061-l2pfl776 343 7 distributions distribution NNS cord-300061-l2pfl776 343 8 of of IN cord-300061-l2pfl776 343 9 S S NNP cord-300061-l2pfl776 343 10 and and CC cord-300061-l2pfl776 343 11 H H NNP cord-300061-l2pfl776 343 12 are be VBP cord-300061-l2pfl776 343 13 indeed indeed RB cord-300061-l2pfl776 343 14 quite quite RB cord-300061-l2pfl776 343 15 related related JJ cord-300061-l2pfl776 343 16 to to IN cord-300061-l2pfl776 343 17 the the DT cord-300061-l2pfl776 343 18 GC GC NNP cord-300061-l2pfl776 343 19 content content NN cord-300061-l2pfl776 343 20 . . . cord-300061-l2pfl776 344 1 But but CC cord-300061-l2pfl776 344 2 that that DT cord-300061-l2pfl776 344 3 is be VBZ cord-300061-l2pfl776 344 4 a a DT cord-300061-l2pfl776 344 5 conclusion conclusion NN cord-300061-l2pfl776 344 6 made make VBN cord-300061-l2pfl776 344 7 by by IN cord-300061-l2pfl776 344 8 myself -PRON- PRP cord-300061-l2pfl776 344 9 in in IN cord-300061-l2pfl776 344 10 the the DT cord-300061-l2pfl776 344 11 original original JJ cord-300061-l2pfl776 344 12 article article NN cord-300061-l2pfl776 344 13 . . . cord-300061-l2pfl776 345 1 Please please UH cord-300061-l2pfl776 345 2 refer refer VB cord-300061-l2pfl776 345 3 to to IN cord-300061-l2pfl776 345 4 the the DT cord-300061-l2pfl776 345 5 figure figure NN cord-300061-l2pfl776 345 6 3 3 CD cord-300061-l2pfl776 345 7 in in IN cord-300061-l2pfl776 345 8 ref ref NN cord-300061-l2pfl776 345 9 . . . cord-300061-l2pfl776 346 1 [ [ -LRB- cord-300061-l2pfl776 346 2 2 2 CD cord-300061-l2pfl776 346 3 ] ] -RRB- cord-300061-l2pfl776 346 4 and and CC cord-300061-l2pfl776 346 5 the the DT cord-300061-l2pfl776 346 6 text text NN cord-300061-l2pfl776 346 7 therein therein RB cord-300061-l2pfl776 346 8 . . . cord-300061-l2pfl776 347 1 The the DT cord-300061-l2pfl776 347 2 author author NN cord-300061-l2pfl776 347 3 asserts assert VBZ cord-300061-l2pfl776 347 4 in in IN cord-300061-l2pfl776 347 5 several several JJ cord-300061-l2pfl776 347 6 places place NNS cord-300061-l2pfl776 347 7 that that WDT cord-300061-l2pfl776 347 8 , , , cord-300061-l2pfl776 347 9 indeed indeed RB cord-300061-l2pfl776 347 10 , , , cord-300061-l2pfl776 347 11 these these DT cord-300061-l2pfl776 347 12 deviations deviation NNS cord-300061-l2pfl776 347 13 are be VBP cord-300061-l2pfl776 347 14 highly highly RB cord-300061-l2pfl776 347 15 meaningful meaningful JJ cord-300061-l2pfl776 347 16 but but CC cord-300061-l2pfl776 347 17 frustratingly frustratingly RB cord-300061-l2pfl776 347 18 fails fail VBZ cord-300061-l2pfl776 347 19 to to TO cord-300061-l2pfl776 347 20 give give VB cord-300061-l2pfl776 347 21 citations citation NNS cord-300061-l2pfl776 347 22 to to TO cord-300061-l2pfl776 347 23 back back VB cord-300061-l2pfl776 347 24 this this DT cord-300061-l2pfl776 347 25 claim claim NN cord-300061-l2pfl776 347 26 up up RP cord-300061-l2pfl776 347 27 . . . cord-300061-l2pfl776 348 1 My -PRON- PRP$ cord-300061-l2pfl776 348 2 own own JJ cord-300061-l2pfl776 348 3 recollection recollection NN cord-300061-l2pfl776 348 4 is be VBZ cord-300061-l2pfl776 348 5 that that IN cord-300061-l2pfl776 348 6 in in IN cord-300061-l2pfl776 348 7 bacteria bacteria NNS cord-300061-l2pfl776 348 8 the the DT cord-300061-l2pfl776 348 9 G g NN cord-300061-l2pfl776 348 10 / / SYM cord-300061-l2pfl776 348 11 C c NN cord-300061-l2pfl776 348 12 - - HYPH cord-300061-l2pfl776 348 13 skew skew NNP cord-300061-l2pfl776 348 14 has have VBZ cord-300061-l2pfl776 348 15 been be VBN cord-300061-l2pfl776 348 16 proposed propose VBN cord-300061-l2pfl776 348 17 to to TO cord-300061-l2pfl776 348 18 be be VB cord-300061-l2pfl776 348 19 a a DT cord-300061-l2pfl776 348 20 result result NN cord-300061-l2pfl776 348 21 of of IN cord-300061-l2pfl776 348 22 different different JJ cord-300061-l2pfl776 348 23 mutational mutational JJ cord-300061-l2pfl776 348 24 spectra spectrum NNS cord-300061-l2pfl776 348 25 acting act VBG cord-300061-l2pfl776 348 26 on on IN cord-300061-l2pfl776 348 27 the the DT cord-300061-l2pfl776 348 28 leading lead VBG cord-300061-l2pfl776 348 29 and and CC cord-300061-l2pfl776 348 30 lagging lagging JJ cord-300061-l2pfl776 348 31 strands strand NNS cord-300061-l2pfl776 348 32 ( ( -LRB- cord-300061-l2pfl776 348 33 and and CC cord-300061-l2pfl776 348 34 would would MD cord-300061-l2pfl776 348 35 thus thus RB cord-300061-l2pfl776 348 36 not not RB cord-300061-l2pfl776 348 37 necessarily necessarily RB cord-300061-l2pfl776 348 38 have have VB cord-300061-l2pfl776 348 39 functional functional JJ cord-300061-l2pfl776 348 40 implications implication NNS cord-300061-l2pfl776 348 41 ) ) -RRB- cord-300061-l2pfl776 348 42 . . . cord-300061-l2pfl776 349 1 Deviations deviation NNS cord-300061-l2pfl776 349 2 from from IN cord-300061-l2pfl776 349 3 PR2 pr2 NN cord-300061-l2pfl776 349 4 result result NN cord-300061-l2pfl776 349 5 from from IN cord-300061-l2pfl776 349 6 both both DT cord-300061-l2pfl776 349 7 mutation mutation NN cord-300061-l2pfl776 349 8 and and CC cord-300061-l2pfl776 349 9 selection selection NN cord-300061-l2pfl776 349 10 pressures pressure NNS cord-300061-l2pfl776 349 11 , , , cord-300061-l2pfl776 349 12 reflecting reflect VBG cord-300061-l2pfl776 349 13 biases bias NNS cord-300061-l2pfl776 349 14 in in IN cord-300061-l2pfl776 349 15 , , , cord-300061-l2pfl776 349 16 e.g. e.g. RB cord-300061-l2pfl776 349 17 , , , cord-300061-l2pfl776 349 18 DNA dna NN cord-300061-l2pfl776 349 19 replication replication NN cord-300061-l2pfl776 349 20 , , , cord-300061-l2pfl776 349 21 transcription transcription NN cord-300061-l2pfl776 349 22 and and CC cord-300061-l2pfl776 349 23 repair repair NN cord-300061-l2pfl776 349 24 . . . cord-300061-l2pfl776 350 1 I -PRON- PRP cord-300061-l2pfl776 350 2 added add VBD cord-300061-l2pfl776 350 3 a a DT cord-300061-l2pfl776 350 4 review review NN cord-300061-l2pfl776 350 5 article article NN cord-300061-l2pfl776 350 6 . . . cord-300061-l2pfl776 351 1 However however RB cord-300061-l2pfl776 351 2 , , , cord-300061-l2pfl776 351 3 this this DT cord-300061-l2pfl776 351 4 seems seem VBZ cord-300061-l2pfl776 351 5 to to TO cord-300061-l2pfl776 351 6 now now RB cord-300061-l2pfl776 351 7 confound confound VB cord-300061-l2pfl776 351 8 the the DT cord-300061-l2pfl776 351 9 question question NN cord-300061-l2pfl776 351 10 of of IN cord-300061-l2pfl776 351 11 local local JJ cord-300061-l2pfl776 351 12 compositional compositional JJ cord-300061-l2pfl776 351 13 biases bias NNS cord-300061-l2pfl776 351 14 and and CC cord-300061-l2pfl776 351 15 their -PRON- PRP$ cord-300061-l2pfl776 351 16 functional functional JJ cord-300061-l2pfl776 351 17 implications implication NNS cord-300061-l2pfl776 351 18 versus versus IN cord-300061-l2pfl776 351 19 global global JJ cord-300061-l2pfl776 351 20 patterns pattern NNS cord-300061-l2pfl776 351 21 of of IN cord-300061-l2pfl776 351 22 base base NN cord-300061-l2pfl776 351 23 composition composition NN cord-300061-l2pfl776 351 24 , , , cord-300061-l2pfl776 351 25 because because IN cord-300061-l2pfl776 351 26 as as RB cord-300061-l2pfl776 351 27 far far RB cord-300061-l2pfl776 351 28 as as IN cord-300061-l2pfl776 351 29 I -PRON- PRP cord-300061-l2pfl776 351 30 can can MD cord-300061-l2pfl776 351 31 tell tell VB cord-300061-l2pfl776 351 32 Elhaik Elhaik NNP cord-300061-l2pfl776 351 33 et et NNP cord-300061-l2pfl776 351 34 al al NNP cord-300061-l2pfl776 351 35 . . NNP cord-300061-l2pfl776 351 36 were be VBD cord-300061-l2pfl776 351 37 talking talk VBG cord-300061-l2pfl776 351 38 about about IN cord-300061-l2pfl776 351 39 global global JJ cord-300061-l2pfl776 351 40 compositional compositional JJ cord-300061-l2pfl776 351 41 patterns pattern NNS cord-300061-l2pfl776 351 42 . . . cord-300061-l2pfl776 352 1 No no UH cord-300061-l2pfl776 352 2 . . . cord-300061-l2pfl776 353 1 Elhaik Elhaik NNP cord-300061-l2pfl776 353 2 et et NNP cord-300061-l2pfl776 353 3 al al NNP cord-300061-l2pfl776 353 4 . . NNP cord-300061-l2pfl776 353 5 concluded conclude VBD cord-300061-l2pfl776 353 6 that that IN cord-300061-l2pfl776 353 7 Z z NN cord-300061-l2pfl776 353 8 - - HYPH cord-300061-l2pfl776 353 9 curve curve NN cord-300061-l2pfl776 353 10 suffers suffer VBZ cord-300061-l2pfl776 353 11 from from IN cord-300061-l2pfl776 353 12 " " `` cord-300061-l2pfl776 353 13 over over IN cord-300061-l2pfl776 353 14 - - HYPH cord-300061-l2pfl776 353 15 dimensionality dimensionality NN cord-300061-l2pfl776 353 16 " " '' cord-300061-l2pfl776 353 17 , , , cord-300061-l2pfl776 353 18 without without IN cord-300061-l2pfl776 353 19 restricting restrict VBG cord-300061-l2pfl776 353 20 their -PRON- PRP$ cord-300061-l2pfl776 353 21 conclusion conclusion NN cord-300061-l2pfl776 353 22 to to IN cord-300061-l2pfl776 353 23 global global JJ cord-300061-l2pfl776 353 24 compositional compositional JJ cord-300061-l2pfl776 353 25 patterns pattern NNS cord-300061-l2pfl776 353 26 only only RB cord-300061-l2pfl776 353 27 . . . cord-300061-l2pfl776 354 1 Z z NN cord-300061-l2pfl776 354 2 - - HYPH cord-300061-l2pfl776 354 3 curve curve NN cord-300061-l2pfl776 354 4 can can MD cord-300061-l2pfl776 354 5 be be VB cord-300061-l2pfl776 354 6 used use VBN cord-300061-l2pfl776 354 7 to to TO cord-300061-l2pfl776 354 8 study study VB cord-300061-l2pfl776 354 9 any any DT cord-300061-l2pfl776 354 10 DNA dna NN cord-300061-l2pfl776 354 11 sequences sequence NNS cord-300061-l2pfl776 354 12 , , , cord-300061-l2pfl776 354 13 such such JJ cord-300061-l2pfl776 354 14 as as IN cord-300061-l2pfl776 354 15 whole whole JJ cord-300061-l2pfl776 354 16 genomes genome NNS cord-300061-l2pfl776 354 17 , , , cord-300061-l2pfl776 354 18 protein protein NN cord-300061-l2pfl776 354 19 coding coding NN cord-300061-l2pfl776 354 20 genes gene NNS cord-300061-l2pfl776 354 21 , , , cord-300061-l2pfl776 354 22 promoter promoter NN cord-300061-l2pfl776 354 23 sequences sequence NNS cord-300061-l2pfl776 354 24 and and CC cord-300061-l2pfl776 354 25 translation translation NN cord-300061-l2pfl776 354 26 start start NN cord-300061-l2pfl776 354 27 sites site NNS cord-300061-l2pfl776 354 28 . . . cord-300061-l2pfl776 355 1 Therefore therefore RB cord-300061-l2pfl776 355 2 , , , cord-300061-l2pfl776 355 3 one one CD cord-300061-l2pfl776 355 4 part part NN cord-300061-l2pfl776 355 5 of of IN cord-300061-l2pfl776 355 6 their -PRON- PRP$ cord-300061-l2pfl776 355 7 analysis analysis NN cord-300061-l2pfl776 355 8 that that WDT cord-300061-l2pfl776 355 9 is be VBZ cord-300061-l2pfl776 355 10 logically logically RB cord-300061-l2pfl776 355 11 flawed flawed JJ cord-300061-l2pfl776 355 12 is be VBZ cord-300061-l2pfl776 355 13 that that IN cord-300061-l2pfl776 355 14 they -PRON- PRP cord-300061-l2pfl776 355 15 analyzed analyze VBD cord-300061-l2pfl776 355 16 a a DT cord-300061-l2pfl776 355 17 subset subset NN cord-300061-l2pfl776 355 18 of of IN cord-300061-l2pfl776 355 19 bacterial bacterial JJ cord-300061-l2pfl776 355 20 genomes genome NNS cord-300061-l2pfl776 355 21 but but CC cord-300061-l2pfl776 355 22 tried try VBD cord-300061-l2pfl776 355 23 to to TO cord-300061-l2pfl776 355 24 make make VB cord-300061-l2pfl776 355 25 a a DT cord-300061-l2pfl776 355 26 general general JJ cord-300061-l2pfl776 355 27 conclusion conclusion NN cord-300061-l2pfl776 355 28 for for IN cord-300061-l2pfl776 355 29 all all DT cord-300061-l2pfl776 355 30 DNA dna NN cord-300061-l2pfl776 355 31 sequences sequence NNS cord-300061-l2pfl776 355 32 . . . cord-300061-l2pfl776 356 1 In in IN cord-300061-l2pfl776 356 2 my -PRON- PRP$ cord-300061-l2pfl776 356 3 rebuttal rebuttal NN cord-300061-l2pfl776 356 4 , , , cord-300061-l2pfl776 356 5 however however RB cord-300061-l2pfl776 356 6 , , , cord-300061-l2pfl776 356 7 I -PRON- PRP cord-300061-l2pfl776 356 8 have have VBP cord-300061-l2pfl776 356 9 to to TO cord-300061-l2pfl776 356 10 show show VB cord-300061-l2pfl776 356 11 separately separately RB cord-300061-l2pfl776 356 12 that that IN cord-300061-l2pfl776 356 13 for for IN cord-300061-l2pfl776 356 14 both both DT cord-300061-l2pfl776 356 15 whole whole JJ cord-300061-l2pfl776 356 16 genomes genome NNS cord-300061-l2pfl776 356 17 and and CC cord-300061-l2pfl776 356 18 short short JJ cord-300061-l2pfl776 356 19 DNA dna NN cord-300061-l2pfl776 356 20 segments segment NNS cord-300061-l2pfl776 356 21 , , , cord-300061-l2pfl776 356 22 their -PRON- PRP$ cord-300061-l2pfl776 356 23 conclusion conclusion NN cord-300061-l2pfl776 356 24 is be VBZ cord-300061-l2pfl776 356 25 wrong wrong JJ cord-300061-l2pfl776 356 26 . . . cord-300061-l2pfl776 357 1 Finally finally RB cord-300061-l2pfl776 357 2 , , , cord-300061-l2pfl776 357 3 the the DT cord-300061-l2pfl776 357 4 remark remark NN cord-300061-l2pfl776 357 5 that that IN cord-300061-l2pfl776 357 6 S S NNP cord-300061-l2pfl776 357 7 can can MD cord-300061-l2pfl776 357 8 be be VB cord-300061-l2pfl776 357 9 calculated calculate VBN cord-300061-l2pfl776 357 10 faster fast RBR cord-300061-l2pfl776 357 11 than than IN cord-300061-l2pfl776 357 12 H h NN cord-300061-l2pfl776 357 13 ' ' '' cord-300061-l2pfl776 357 14 which which WDT cord-300061-l2pfl776 357 15 is be VBZ cord-300061-l2pfl776 357 16 especially especially RB cord-300061-l2pfl776 357 17 important important JJ cord-300061-l2pfl776 357 18 for for IN cord-300061-l2pfl776 357 19 handling handle VBG cord-300061-l2pfl776 357 20 large large JJ cord-300061-l2pfl776 357 21 genomes genome NNS cord-300061-l2pfl776 357 22 ' ' '' cord-300061-l2pfl776 357 23 does do VBZ cord-300061-l2pfl776 357 24 not not RB cord-300061-l2pfl776 357 25 make make VB cord-300061-l2pfl776 357 26 a a DT cord-300061-l2pfl776 357 27 lot lot NN cord-300061-l2pfl776 357 28 of of IN cord-300061-l2pfl776 357 29 sense sense NN cord-300061-l2pfl776 357 30 to to IN cord-300061-l2pfl776 357 31 me -PRON- PRP cord-300061-l2pfl776 357 32 . . . cord-300061-l2pfl776 358 1 If if IN cord-300061-l2pfl776 358 2 one one PRP cord-300061-l2pfl776 358 3 really really RB cord-300061-l2pfl776 358 4 worries worry VBZ cord-300061-l2pfl776 358 5 about about IN cord-300061-l2pfl776 358 6 computational computational JJ cord-300061-l2pfl776 358 7 costs cost NNS cord-300061-l2pfl776 358 8 in in IN cord-300061-l2pfl776 358 9 calculating calculate VBG cord-300061-l2pfl776 358 10 H H NNP cord-300061-l2pfl776 358 11 one one PRP cord-300061-l2pfl776 358 12 could could MD cord-300061-l2pfl776 358 13 calculate calculate VB cord-300061-l2pfl776 358 14 f*log(f f*log(f NNP cord-300061-l2pfl776 358 15 ) ) -RRB- cord-300061-l2pfl776 358 16 for for IN cord-300061-l2pfl776 358 17 all all DT cord-300061-l2pfl776 358 18 values value NNS cord-300061-l2pfl776 358 19 of of IN cord-300061-l2pfl776 358 20 before before IN cord-300061-l2pfl776 358 21 - - HYPH cord-300061-l2pfl776 358 22 hand hand NN cord-300061-l2pfl776 358 23 and and CC cord-300061-l2pfl776 358 24 store store VB cord-300061-l2pfl776 358 25 them -PRON- PRP cord-300061-l2pfl776 358 26 in in IN cord-300061-l2pfl776 358 27 a a DT cord-300061-l2pfl776 358 28 table table NN cord-300061-l2pfl776 358 29 . . . cord-300061-l2pfl776 359 1 The the DT cord-300061-l2pfl776 359 2 reviewer reviewer NN cord-300061-l2pfl776 359 3 finally finally RB cord-300061-l2pfl776 359 4 suggests suggest VBZ cord-300061-l2pfl776 359 5 that that IN cord-300061-l2pfl776 359 6 one one PRP cord-300061-l2pfl776 359 7 could could MD cord-300061-l2pfl776 359 8 calculate calculate VB cord-300061-l2pfl776 359 9 f*log(f f*log(f NNP cord-300061-l2pfl776 359 10 ) ) -RRB- cord-300061-l2pfl776 359 11 for for IN cord-300061-l2pfl776 359 12 all all DT cord-300061-l2pfl776 359 13 values value NNS cord-300061-l2pfl776 359 14 beforehand beforehand RB cord-300061-l2pfl776 359 15 and and CC cord-300061-l2pfl776 359 16 store store VB cord-300061-l2pfl776 359 17 them -PRON- PRP cord-300061-l2pfl776 359 18 in in IN cord-300061-l2pfl776 359 19 a a DT cord-300061-l2pfl776 359 20 table table NN cord-300061-l2pfl776 359 21 . . . cord-300061-l2pfl776 360 1 However however RB cord-300061-l2pfl776 360 2 , , , cord-300061-l2pfl776 360 3 this this DT cord-300061-l2pfl776 360 4 suggestion suggestion NN cord-300061-l2pfl776 360 5 is be VBZ cord-300061-l2pfl776 360 6 not not RB cord-300061-l2pfl776 360 7 practical practical JJ cord-300061-l2pfl776 360 8 . . . cord-300061-l2pfl776 361 1 Both both DT cord-300061-l2pfl776 361 2 S S NNP cord-300061-l2pfl776 361 3 and and CC cord-300061-l2pfl776 361 4 H H NNP cord-300061-l2pfl776 361 5 are be VBP cord-300061-l2pfl776 361 6 real real JJ cord-300061-l2pfl776 361 7 numbers number NNS cord-300061-l2pfl776 361 8 . . . cord-300061-l2pfl776 362 1 The the DT cord-300061-l2pfl776 362 2 number number NN cord-300061-l2pfl776 362 3 of of IN cord-300061-l2pfl776 362 4 all all DT cord-300061-l2pfl776 362 5 real real JJ cord-300061-l2pfl776 362 6 numbers number NNS cord-300061-l2pfl776 362 7 within within IN cord-300061-l2pfl776 362 8 the the DT cord-300061-l2pfl776 362 9 interval interval NN cord-300061-l2pfl776 362 10 , , , cord-300061-l2pfl776 362 11 e.g. e.g. RB cord-300061-l2pfl776 362 12 , , , cord-300061-l2pfl776 362 13 [ [ -LRB- cord-300061-l2pfl776 362 14 0,1 0,1 LS cord-300061-l2pfl776 362 15 ] ] -RRB- cord-300061-l2pfl776 362 16 is be VBZ cord-300061-l2pfl776 362 17 infinite infinite JJ cord-300061-l2pfl776 362 18 . . . cord-300061-l2pfl776 363 1 Therefore therefore RB cord-300061-l2pfl776 363 2 , , , cord-300061-l2pfl776 363 3 the the DT cord-300061-l2pfl776 363 4 table table NN cord-300061-l2pfl776 363 5 that that WDT cord-300061-l2pfl776 363 6 contains contain VBZ cord-300061-l2pfl776 363 7 ' ' `` cord-300061-l2pfl776 363 8 all all DT cord-300061-l2pfl776 363 9 values value NNS cord-300061-l2pfl776 363 10 ' ' '' cord-300061-l2pfl776 363 11 can can MD cord-300061-l2pfl776 363 12 not not RB cord-300061-l2pfl776 363 13 be be VB cord-300061-l2pfl776 363 14 saved save VBN cord-300061-l2pfl776 363 15 , , , cord-300061-l2pfl776 363 16 unless unless IN cord-300061-l2pfl776 363 17 with with IN cord-300061-l2pfl776 363 18 the the DT cord-300061-l2pfl776 363 19 infinitely infinitely RB cord-300061-l2pfl776 363 20 large large JJ cord-300061-l2pfl776 363 21 computer computer NN cord-300061-l2pfl776 363 22 storage storage NN cord-300061-l2pfl776 363 23 , , , cord-300061-l2pfl776 363 24 which which WDT cord-300061-l2pfl776 363 25 , , , cord-300061-l2pfl776 363 26 however however RB cord-300061-l2pfl776 363 27 , , , cord-300061-l2pfl776 363 28 does do VBZ cord-300061-l2pfl776 363 29 not not RB cord-300061-l2pfl776 363 30 exist exist VB cord-300061-l2pfl776 363 31 . . . cord-300061-l2pfl776 364 1 Analysis analysis NN cord-300061-l2pfl776 364 2 of of IN cord-300061-l2pfl776 364 3 distribution distribution NN cord-300061-l2pfl776 364 4 of of IN cord-300061-l2pfl776 364 5 bases basis NNS cord-300061-l2pfl776 364 6 in in IN cord-300061-l2pfl776 364 7 the the DT cord-300061-l2pfl776 364 8 coding coding NN cord-300061-l2pfl776 364 9 sequences sequence NNS cord-300061-l2pfl776 364 10 by by IN cord-300061-l2pfl776 364 11 a a DT cord-300061-l2pfl776 364 12 diagrammatic diagrammatic JJ cord-300061-l2pfl776 364 13 technique technique NN cord-300061-l2pfl776 365 1 A a DT cord-300061-l2pfl776 365 2 nucleotide nucleotide JJ cord-300061-l2pfl776 365 3 composition composition NN cord-300061-l2pfl776 365 4 constraint constraint NN cord-300061-l2pfl776 365 5 of of IN cord-300061-l2pfl776 365 6 genome genome NN cord-300061-l2pfl776 365 7 sequences sequence NNS cord-300061-l2pfl776 365 8 Genome Genome NNP cord-300061-l2pfl776 365 9 order order NN cord-300061-l2pfl776 365 10 index index NN cord-300061-l2pfl776 365 11 ' ' `` cord-300061-l2pfl776 365 12 should should MD cord-300061-l2pfl776 365 13 not not RB cord-300061-l2pfl776 365 14 be be VB cord-300061-l2pfl776 365 15 used use VBN cord-300061-l2pfl776 365 16 for for IN cord-300061-l2pfl776 365 17 defining define VBG cord-300061-l2pfl776 365 18 compositional compositional JJ cord-300061-l2pfl776 365 19 constraints constraint NNS cord-300061-l2pfl776 365 20 in in IN cord-300061-l2pfl776 365 21 nucleotide nucleotide JJ cord-300061-l2pfl776 365 22 sequences sequence NNS cord-300061-l2pfl776 366 1 A a DT cord-300061-l2pfl776 366 2 rebuttal rebuttal NN cord-300061-l2pfl776 366 3 to to IN cord-300061-l2pfl776 366 4 the the DT cord-300061-l2pfl776 366 5 comments comment NNS cord-300061-l2pfl776 366 6 on on IN cord-300061-l2pfl776 366 7 the the DT cord-300061-l2pfl776 366 8 genome genome NN cord-300061-l2pfl776 366 9 order order NN cord-300061-l2pfl776 366 10 index index NN cord-300061-l2pfl776 366 11 Genome Genome NNP cord-300061-l2pfl776 366 12 order order NN cord-300061-l2pfl776 366 13 index index NN cord-300061-l2pfl776 366 14 ' ' `` cord-300061-l2pfl776 366 15 should should MD cord-300061-l2pfl776 366 16 not not RB cord-300061-l2pfl776 366 17 be be VB cord-300061-l2pfl776 366 18 used use VBN cord-300061-l2pfl776 366 19 for for IN cord-300061-l2pfl776 366 20 defining define VBG cord-300061-l2pfl776 366 21 compositional compositional JJ cord-300061-l2pfl776 366 22 constraints constraint NNS cord-300061-l2pfl776 366 23 in in IN cord-300061-l2pfl776 366 24 nucleotide nucleotide JJ cord-300061-l2pfl776 366 25 sequences sequence NNS cord-300061-l2pfl776 366 26 - - : cord-300061-l2pfl776 366 27 a a DT cord-300061-l2pfl776 366 28 case case NN cord-300061-l2pfl776 366 29 study study NN cord-300061-l2pfl776 366 30 of of IN cord-300061-l2pfl776 366 31 the the DT cord-300061-l2pfl776 366 32 Z z NN cord-300061-l2pfl776 366 33 - - HYPH cord-300061-l2pfl776 366 34 curve curve NN cord-300061-l2pfl776 366 35 Segmentation segmentation NN cord-300061-l2pfl776 366 36 algorithm algorithm NN cord-300061-l2pfl776 366 37 for for IN cord-300061-l2pfl776 366 38 DNA dna NN cord-300061-l2pfl776 366 39 sequences sequence NNS cord-300061-l2pfl776 366 40 Separation separation NN cord-300061-l2pfl776 366 41 of of IN cord-300061-l2pfl776 366 42 B. B. NNP cord-300061-l2pfl776 366 43 subtilis subtilis NN cord-300061-l2pfl776 366 44 DNA DNA NNP cord-300061-l2pfl776 366 45 into into IN cord-300061-l2pfl776 366 46 complementary complementary JJ cord-300061-l2pfl776 366 47 strands strand NNS cord-300061-l2pfl776 366 48 . . . cord-300061-l2pfl776 367 1 3 3 LS cord-300061-l2pfl776 367 2 . . . cord-300061-l2pfl776 368 1 Direct direct JJ cord-300061-l2pfl776 368 2 analysis analysis NN cord-300061-l2pfl776 369 1 A a DT cord-300061-l2pfl776 369 2 test test NN cord-300061-l2pfl776 369 3 of of IN cord-300061-l2pfl776 369 4 Chargaff Chargaff NNP cord-300061-l2pfl776 369 5 's 's POS cord-300061-l2pfl776 369 6 second second JJ cord-300061-l2pfl776 369 7 rule rule NN cord-300061-l2pfl776 369 8 Asymmetric asymmetric JJ cord-300061-l2pfl776 369 9 substitution substitution NN cord-300061-l2pfl776 369 10 patterns pattern NNS cord-300061-l2pfl776 369 11 : : : cord-300061-l2pfl776 369 12 a a DT cord-300061-l2pfl776 369 13 review review NN cord-300061-l2pfl776 369 14 of of IN cord-300061-l2pfl776 369 15 possible possible JJ cord-300061-l2pfl776 369 16 underlying underlying JJ cord-300061-l2pfl776 369 17 mutational mutational JJ cord-300061-l2pfl776 369 18 or or CC cord-300061-l2pfl776 369 19 selective selective JJ cord-300061-l2pfl776 369 20 mechanisms mechanism NNS cord-300061-l2pfl776 369 21 On on IN cord-300061-l2pfl776 369 22 measures measure NNS cord-300061-l2pfl776 369 23 of of IN cord-300061-l2pfl776 369 24 information information NN cord-300061-l2pfl776 369 25 and and CC cord-300061-l2pfl776 369 26 entropy entropy NN cord-300061-l2pfl776 369 27 Relations relation NNS cord-300061-l2pfl776 369 28 between between IN cord-300061-l2pfl776 369 29 Shannon Shannon NNP cord-300061-l2pfl776 369 30 entropy entropy NN cord-300061-l2pfl776 369 31 and and CC cord-300061-l2pfl776 369 32 genome genome NN cord-300061-l2pfl776 369 33 order order NN cord-300061-l2pfl776 369 34 index index NN cord-300061-l2pfl776 369 35 in in IN cord-300061-l2pfl776 369 36 segmenting segment VBG cord-300061-l2pfl776 369 37 DNA dna NN cord-300061-l2pfl776 369 38 sequences sequence NNS cord-300061-l2pfl776 369 39 Ori Ori NNP cord-300061-l2pfl776 369 40 - - HYPH cord-300061-l2pfl776 369 41 Finder Finder NNP cord-300061-l2pfl776 369 42 : : : cord-300061-l2pfl776 369 43 a a DT cord-300061-l2pfl776 369 44 web web NN cord-300061-l2pfl776 369 45 - - HYPH cord-300061-l2pfl776 369 46 based base VBN cord-300061-l2pfl776 369 47 system system NN cord-300061-l2pfl776 369 48 for for IN cord-300061-l2pfl776 369 49 finding find VBG cord-300061-l2pfl776 369 50 oriCs oric NNS cord-300061-l2pfl776 369 51 in in IN cord-300061-l2pfl776 369 52 unannotated unannotated JJ cord-300061-l2pfl776 369 53 bacterial bacterial JJ cord-300061-l2pfl776 369 54 genomes genome NNS cord-300061-l2pfl776 369 55 DoriC DoriC NNP cord-300061-l2pfl776 369 56 : : : cord-300061-l2pfl776 369 57 a a DT cord-300061-l2pfl776 369 58 database database NN cord-300061-l2pfl776 369 59 of of IN cord-300061-l2pfl776 369 60 oriC oriC NNS cord-300061-l2pfl776 369 61 regions region NNS cord-300061-l2pfl776 369 62 in in IN cord-300061-l2pfl776 369 63 bacterial bacterial JJ cord-300061-l2pfl776 369 64 genomes genome NNS cord-300061-l2pfl776 369 65 Identification identification NN cord-300061-l2pfl776 369 66 of of IN cord-300061-l2pfl776 369 67 replication replication NN cord-300061-l2pfl776 369 68 origins origin NNS cord-300061-l2pfl776 369 69 in in IN cord-300061-l2pfl776 369 70 archaeal archaeal JJ cord-300061-l2pfl776 369 71 genomes genome NNS cord-300061-l2pfl776 369 72 based base VBN cord-300061-l2pfl776 369 73 on on IN cord-300061-l2pfl776 369 74 the the DT cord-300061-l2pfl776 369 75 Z z NN cord-300061-l2pfl776 369 76 - - HYPH cord-300061-l2pfl776 369 77 curve curve NN cord-300061-l2pfl776 369 78 method method NN cord-300061-l2pfl776 369 79 Multiple multiple JJ cord-300061-l2pfl776 369 80 replication replication NN cord-300061-l2pfl776 369 81 origins origin NNS cord-300061-l2pfl776 369 82 of of IN cord-300061-l2pfl776 369 83 the the DT cord-300061-l2pfl776 369 84 archaeon archaeon NNP cord-300061-l2pfl776 369 85 Halobacterium Halobacterium NNP cord-300061-l2pfl776 369 86 species specie NNS cord-300061-l2pfl776 370 1 NRC-1 NRC-1 NNP cord-300061-l2pfl776 370 2 Identification identification NN cord-300061-l2pfl776 370 3 of of IN cord-300061-l2pfl776 370 4 two two CD cord-300061-l2pfl776 370 5 origins origin NNS cord-300061-l2pfl776 370 6 of of IN cord-300061-l2pfl776 370 7 replication replication NN cord-300061-l2pfl776 370 8 in in IN cord-300061-l2pfl776 370 9 the the DT cord-300061-l2pfl776 370 10 single single JJ cord-300061-l2pfl776 370 11 chromosome chromosome NN cord-300061-l2pfl776 370 12 of of IN cord-300061-l2pfl776 370 13 the the DT cord-300061-l2pfl776 370 14 archaeon archaeon NNP cord-300061-l2pfl776 371 1 Sulfolobus Sulfolobus NNP cord-300061-l2pfl776 371 2 solfataricus solfataricus NNP cord-300061-l2pfl776 371 3 Biochemical biochemical JJ cord-300061-l2pfl776 371 4 analysis analysis NN cord-300061-l2pfl776 371 5 of of IN cord-300061-l2pfl776 371 6 a a DT cord-300061-l2pfl776 371 7 DNA dna NN cord-300061-l2pfl776 371 8 replication replication NN cord-300061-l2pfl776 371 9 origin origin NN cord-300061-l2pfl776 371 10 in in IN cord-300061-l2pfl776 371 11 the the DT cord-300061-l2pfl776 371 12 archaeon archaeon NNP cord-300061-l2pfl776 372 1 Aeropyrum Aeropyrum NNP cord-300061-l2pfl776 372 2 pernix pernix NNP cord-300061-l2pfl776 372 3 Recognition Recognition NNP cord-300061-l2pfl776 372 4 of of IN cord-300061-l2pfl776 372 5 protein protein NN cord-300061-l2pfl776 372 6 coding coding NN cord-300061-l2pfl776 372 7 genes gene NNS cord-300061-l2pfl776 372 8 in in IN cord-300061-l2pfl776 372 9 the the DT cord-300061-l2pfl776 372 10 yeast yeast NN cord-300061-l2pfl776 372 11 genome genome NN cord-300061-l2pfl776 372 12 at at IN cord-300061-l2pfl776 372 13 better well JJR cord-300061-l2pfl776 372 14 than than IN cord-300061-l2pfl776 372 15 95 95 CD cord-300061-l2pfl776 372 16 % % NN cord-300061-l2pfl776 372 17 accuracy accuracy NN cord-300061-l2pfl776 372 18 based base VBN cord-300061-l2pfl776 372 19 on on IN cord-300061-l2pfl776 372 20 the the DT cord-300061-l2pfl776 372 21 Z z NN cord-300061-l2pfl776 372 22 curve curve NN cord-300061-l2pfl776 372 23 Human Human NNP cord-300061-l2pfl776 372 24 Pol Pol NNP cord-300061-l2pfl776 372 25 II II NNP cord-300061-l2pfl776 372 26 promoter promoter NN cord-300061-l2pfl776 372 27 recognition recognition NN cord-300061-l2pfl776 372 28 based base VBN cord-300061-l2pfl776 372 29 on on IN cord-300061-l2pfl776 372 30 primary primary JJ cord-300061-l2pfl776 372 31 sequences sequence NNS cord-300061-l2pfl776 372 32 and and CC cord-300061-l2pfl776 372 33 free free JJ cord-300061-l2pfl776 372 34 energy energy NN cord-300061-l2pfl776 372 35 of of IN cord-300061-l2pfl776 372 36 dinucleotides dinucleotide NNS cord-300061-l2pfl776 372 37 GS GS NNP cord-300061-l2pfl776 372 38 - - HYPH cord-300061-l2pfl776 372 39 Finder Finder NNP cord-300061-l2pfl776 372 40 : : : cord-300061-l2pfl776 373 1 a a DT cord-300061-l2pfl776 373 2 program program NN cord-300061-l2pfl776 373 3 to to TO cord-300061-l2pfl776 373 4 find find VB cord-300061-l2pfl776 373 5 bacterial bacterial JJ cord-300061-l2pfl776 373 6 gene gene NN cord-300061-l2pfl776 373 7 start start NN cord-300061-l2pfl776 373 8 sites site NNS cord-300061-l2pfl776 373 9 with with IN cord-300061-l2pfl776 373 10 a a DT cord-300061-l2pfl776 373 11 self self NN cord-300061-l2pfl776 373 12 - - HYPH cord-300061-l2pfl776 373 13 training training NN cord-300061-l2pfl776 373 14 method method NN cord-300061-l2pfl776 373 15 ZCURVE ZCURVE NNP cord-300061-l2pfl776 373 16 : : : cord-300061-l2pfl776 373 17 a a DT cord-300061-l2pfl776 373 18 new new JJ cord-300061-l2pfl776 373 19 system system NN cord-300061-l2pfl776 373 20 for for IN cord-300061-l2pfl776 373 21 recognizing recognize VBG cord-300061-l2pfl776 373 22 protein protein NN cord-300061-l2pfl776 373 23 - - HYPH cord-300061-l2pfl776 373 24 coding code VBG cord-300061-l2pfl776 373 25 genes gene NNS cord-300061-l2pfl776 373 26 in in IN cord-300061-l2pfl776 373 27 bacterial bacterial JJ cord-300061-l2pfl776 373 28 and and CC cord-300061-l2pfl776 373 29 archaeal archaeal JJ cord-300061-l2pfl776 373 30 genomes genome NNS cord-300061-l2pfl776 373 31 ZCURVE_V zcurve_v VBP cord-300061-l2pfl776 373 32 : : : cord-300061-l2pfl776 373 33 a a DT cord-300061-l2pfl776 373 34 new new JJ cord-300061-l2pfl776 373 35 self self NN cord-300061-l2pfl776 373 36 - - HYPH cord-300061-l2pfl776 373 37 training train VBG cord-300061-l2pfl776 373 38 system system NN cord-300061-l2pfl776 373 39 for for IN cord-300061-l2pfl776 373 40 recognizing recognize VBG cord-300061-l2pfl776 373 41 protein protein NN cord-300061-l2pfl776 373 42 - - HYPH cord-300061-l2pfl776 373 43 coding code VBG cord-300061-l2pfl776 373 44 genes gene NNS cord-300061-l2pfl776 373 45 in in IN cord-300061-l2pfl776 373 46 viral viral JJ cord-300061-l2pfl776 373 47 and and CC cord-300061-l2pfl776 373 48 phage phage NN cord-300061-l2pfl776 373 49 genomes genome NNS cord-300061-l2pfl776 374 1 ZCURVE_CoV ZCURVE_CoV NNP cord-300061-l2pfl776 375 1 : : : cord-300061-l2pfl776 375 2 a a DT cord-300061-l2pfl776 375 3 new new JJ cord-300061-l2pfl776 375 4 system system NN cord-300061-l2pfl776 375 5 to to TO cord-300061-l2pfl776 375 6 recognize recognize VB cord-300061-l2pfl776 375 7 protein protein NN cord-300061-l2pfl776 375 8 coding code VBG cord-300061-l2pfl776 375 9 genes gene NNS cord-300061-l2pfl776 375 10 in in IN cord-300061-l2pfl776 375 11 coronavirus coronavirus NN cord-300061-l2pfl776 375 12 genomes genome NNS cord-300061-l2pfl776 375 13 , , , cord-300061-l2pfl776 375 14 and and CC cord-300061-l2pfl776 375 15 its -PRON- PRP$ cord-300061-l2pfl776 375 16 applications application NNS cord-300061-l2pfl776 375 17 in in IN cord-300061-l2pfl776 375 18 analyzing analyze VBG cord-300061-l2pfl776 375 19 SARS SARS NNP cord-300061-l2pfl776 375 20 - - HYPH cord-300061-l2pfl776 375 21 CoV CoV NNP cord-300061-l2pfl776 375 22 genomes genome NNS cord-300061-l2pfl776 375 23 Comparison comparison NN cord-300061-l2pfl776 375 24 of of IN cord-300061-l2pfl776 375 25 various various JJ cord-300061-l2pfl776 375 26 algorithms algorithm NNS cord-300061-l2pfl776 375 27 for for IN cord-300061-l2pfl776 375 28 recognizing recognize VBG cord-300061-l2pfl776 375 29 short short JJ cord-300061-l2pfl776 375 30 coding coding NN cord-300061-l2pfl776 375 31 sequences sequence NNS cord-300061-l2pfl776 375 32 of of IN cord-300061-l2pfl776 375 33 human human JJ cord-300061-l2pfl776 375 34 genes gene NNS cord-300061-l2pfl776 375 35 Unique unique JJ cord-300061-l2pfl776 375 36 physiological physiological JJ cord-300061-l2pfl776 375 37 and and CC cord-300061-l2pfl776 375 38 pathogenic pathogenic JJ cord-300061-l2pfl776 375 39 features feature NNS cord-300061-l2pfl776 375 40 of of IN cord-300061-l2pfl776 375 41 Leptospira Leptospira NNP cord-300061-l2pfl776 375 42 interrogans interrogan NNS cord-300061-l2pfl776 375 43 revealed reveal VBN cord-300061-l2pfl776 375 44 by by IN cord-300061-l2pfl776 375 45 whole whole JJ cord-300061-l2pfl776 375 46 - - HYPH cord-300061-l2pfl776 375 47 genome genome NN cord-300061-l2pfl776 375 48 sequencing sequencing NN cord-300061-l2pfl776 375 49 Comparative comparative JJ cord-300061-l2pfl776 375 50 analysis analysis NN cord-300061-l2pfl776 375 51 of of IN cord-300061-l2pfl776 375 52 the the DT cord-300061-l2pfl776 375 53 complete complete JJ cord-300061-l2pfl776 375 54 genome genome NN cord-300061-l2pfl776 375 55 sequence sequence NN cord-300061-l2pfl776 375 56 of of IN cord-300061-l2pfl776 375 57 the the DT cord-300061-l2pfl776 375 58 plant plant NN cord-300061-l2pfl776 375 59 growth growth NN cord-300061-l2pfl776 375 60 - - HYPH cord-300061-l2pfl776 375 61 promoting promote VBG cord-300061-l2pfl776 375 62 bacterium bacterium NN cord-300061-l2pfl776 375 63 Bacillus bacillus NN cord-300061-l2pfl776 376 1 amyloliquefaciens amyloliquefaciens NNP cord-300061-l2pfl776 377 1 FZB42 FZB42 NFP cord-300061-l2pfl776 377 2 Complete complete VB cord-300061-l2pfl776 377 3 Genome Genome NNP cord-300061-l2pfl776 377 4 Sequence sequence NN cord-300061-l2pfl776 377 5 of of IN cord-300061-l2pfl776 377 6 Bacillus bacillus NN cord-300061-l2pfl776 378 1 thuringiensis thuringiensis NNP cord-300061-l2pfl776 378 2 Mutant Mutant NNP cord-300061-l2pfl776 378 3 Strain Strain NNP cord-300061-l2pfl776 379 1 BMB171 BMB171 NNP cord-300061-l2pfl776 379 2 Complete complete JJ cord-300061-l2pfl776 379 3 genome genome NN cord-300061-l2pfl776 379 4 sequence sequence NN cord-300061-l2pfl776 379 5 of of IN cord-300061-l2pfl776 379 6 the the DT cord-300061-l2pfl776 379 7 rifamycin rifamycin NN cord-300061-l2pfl776 379 8 SV SV NNP cord-300061-l2pfl776 379 9 - - HYPH cord-300061-l2pfl776 379 10 producing produce VBG cord-300061-l2pfl776 379 11 Amycolatopsis Amycolatopsis NNP cord-300061-l2pfl776 379 12 mediterranei mediterranei NN cord-300061-l2pfl776 379 13 U32 U32 NNP cord-300061-l2pfl776 379 14 revealed reveal VBD cord-300061-l2pfl776 379 15 its -PRON- PRP$ cord-300061-l2pfl776 379 16 genetic genetic JJ cord-300061-l2pfl776 379 17 characteristics characteristic NNS cord-300061-l2pfl776 379 18 in in IN cord-300061-l2pfl776 379 19 phylogeny phylogeny NN cord-300061-l2pfl776 379 20 and and CC cord-300061-l2pfl776 379 21 metabolism metabolism NN cord-300061-l2pfl776 379 22 Genetic genetic JJ cord-300061-l2pfl776 379 23 Basis Basis NNP cord-300061-l2pfl776 379 24 of of IN cord-300061-l2pfl776 379 25 Virulence Virulence NNP cord-300061-l2pfl776 379 26 Attenuation Attenuation NNP cord-300061-l2pfl776 379 27 Revealed reveal VBN cord-300061-l2pfl776 379 28 by by IN cord-300061-l2pfl776 379 29 Comparative Comparative NNP cord-300061-l2pfl776 379 30 Genomic Genomic NNP cord-300061-l2pfl776 379 31 Analysis Analysis NNP cord-300061-l2pfl776 379 32 of of IN cord-300061-l2pfl776 379 33 Mycobacterium Mycobacterium NNP cord-300061-l2pfl776 379 34 tuberculosis tuberculosis NN cord-300061-l2pfl776 379 35 Strain Strain NNP cord-300061-l2pfl776 379 36 H37Ra H37Ra NNP cord-300061-l2pfl776 379 37 versus versus IN cord-300061-l2pfl776 379 38 H37Rv H37Rv NNP cord-300061-l2pfl776 379 39 Kellis Kellis NNP cord-300061-l2pfl776 379 40 M M NNP cord-300061-l2pfl776 379 41 : : : cord-300061-l2pfl776 379 42 Performance performance NN cord-300061-l2pfl776 379 43 and and CC cord-300061-l2pfl776 379 44 scalability scalability NN cord-300061-l2pfl776 379 45 of of IN cord-300061-l2pfl776 379 46 discriminative discriminative JJ cord-300061-l2pfl776 379 47 metrics metric NNS cord-300061-l2pfl776 379 48 for for IN cord-300061-l2pfl776 379 49 comparative comparative JJ cord-300061-l2pfl776 379 50 gene gene NN cord-300061-l2pfl776 379 51 identification identification NN cord-300061-l2pfl776 379 52 in in IN cord-300061-l2pfl776 379 53 12 12 CD cord-300061-l2pfl776 379 54 Drosophila Drosophila NNP cord-300061-l2pfl776 379 55 genomes genome NNS cord-300061-l2pfl776 379 56 Identification identification NN cord-300061-l2pfl776 379 57 of of IN cord-300061-l2pfl776 379 58 a a DT cord-300061-l2pfl776 379 59 new new JJ cord-300061-l2pfl776 379 60 human human JJ cord-300061-l2pfl776 379 61 coronavirus coronavirus NN cord-300061-l2pfl776 380 1 The the DT cord-300061-l2pfl776 380 2 novel novel JJ cord-300061-l2pfl776 380 3 human human NN cord-300061-l2pfl776 380 4 coronaviruses coronaviruse NNS cord-300061-l2pfl776 381 1 NL63 NL63 NNP cord-300061-l2pfl776 381 2 and and CC cord-300061-l2pfl776 381 3 HKU1 HKU1 NNP cord-300061-l2pfl776 381 4 Prevalence prevalence NN cord-300061-l2pfl776 381 5 and and CC cord-300061-l2pfl776 381 6 genetic genetic JJ cord-300061-l2pfl776 381 7 diversity diversity NN cord-300061-l2pfl776 381 8 of of IN cord-300061-l2pfl776 381 9 coronaviruses coronaviruse NNS cord-300061-l2pfl776 381 10 in in IN cord-300061-l2pfl776 381 11 bats bat NNS cord-300061-l2pfl776 381 12 from from IN cord-300061-l2pfl776 381 13 China China NNP cord-300061-l2pfl776 382 1 The the DT cord-300061-l2pfl776 382 2 genome genome NN cord-300061-l2pfl776 382 3 of of IN cord-300061-l2pfl776 382 4 the the DT cord-300061-l2pfl776 382 5 novel novel JJ cord-300061-l2pfl776 382 6 phage phage NN cord-300061-l2pfl776 382 7 Rtp Rtp NNP cord-300061-l2pfl776 382 8 , , , cord-300061-l2pfl776 382 9 with with IN cord-300061-l2pfl776 382 10 a a DT cord-300061-l2pfl776 382 11 rosette rosette NN cord-300061-l2pfl776 382 12 - - HYPH cord-300061-l2pfl776 382 13 like like JJ cord-300061-l2pfl776 382 14 tail tail NN cord-300061-l2pfl776 382 15 tip tip NN cord-300061-l2pfl776 382 16 , , , cord-300061-l2pfl776 382 17 is be VBZ cord-300061-l2pfl776 382 18 homologous homologous JJ cord-300061-l2pfl776 382 19 to to IN cord-300061-l2pfl776 382 20 the the DT cord-300061-l2pfl776 382 21 genome genome NN cord-300061-l2pfl776 382 22 of of IN cord-300061-l2pfl776 382 23 phage phage NN cord-300061-l2pfl776 382 24 T1 T1 NNP cord-300061-l2pfl776 382 25 Characterization characterization NN cord-300061-l2pfl776 382 26 of of IN cord-300061-l2pfl776 382 27 a a DT cord-300061-l2pfl776 382 28 New New NNP cord-300061-l2pfl776 382 29 Plasmid Plasmid NNP cord-300061-l2pfl776 382 30 - - HYPH cord-300061-l2pfl776 382 31 Like Like NNP cord-300061-l2pfl776 382 32 Prophage Prophage NNP cord-300061-l2pfl776 382 33 in in IN cord-300061-l2pfl776 382 34 a a DT cord-300061-l2pfl776 382 35 Pandemic pandemic NN cord-300061-l2pfl776 383 1 Vibrio Vibrio NNP cord-300061-l2pfl776 383 2 parahaemolyticus parahaemolyticus NNP cord-300061-l2pfl776 383 3 O3 O3 NNP cord-300061-l2pfl776 383 4 : : : cord-300061-l2pfl776 384 1 K6 K6 NNP cord-300061-l2pfl776 384 2 Strain Strain NNP cord-300061-l2pfl776 384 3 Cite Cite NNP cord-300061-l2pfl776 384 4 this this DT cord-300061-l2pfl776 384 5 article article NN cord-300061-l2pfl776 384 6 as as IN cord-300061-l2pfl776 384 7 : : : cord-300061-l2pfl776 384 8 Zhang Zhang NNP cord-300061-l2pfl776 384 9 : : : cord-300061-l2pfl776 385 1 A a DT cord-300061-l2pfl776 385 2 rebuttal rebuttal NN cord-300061-l2pfl776 385 3 to to IN cord-300061-l2pfl776 385 4 the the DT cord-300061-l2pfl776 385 5 comments comment NNS cord-300061-l2pfl776 385 6 on on IN cord-300061-l2pfl776 385 7 the the DT cord-300061-l2pfl776 385 8 genome genome NN cord-300061-l2pfl776 385 9 order order NN cord-300061-l2pfl776 385 10 index index NN cord-300061-l2pfl776 385 11 and and CC cord-300061-l2pfl776 385 12 the the DT cord-300061-l2pfl776 385 13 Z z NN cord-300061-l2pfl776 385 14 - - HYPH cord-300061-l2pfl776 385 15 curve curve NN cord-300061-l2pfl776 385 16 Authors author NNS cord-300061-l2pfl776 385 17 ' ' POS cord-300061-l2pfl776 385 18 contributions contribution NNS cord-300061-l2pfl776 385 19 RZ RZ NNP cord-300061-l2pfl776 385 20 analyzed analyze VBD cord-300061-l2pfl776 385 21 the the DT cord-300061-l2pfl776 385 22 data datum NNS cord-300061-l2pfl776 385 23 and and CC cord-300061-l2pfl776 385 24 wrote write VBD cord-300061-l2pfl776 385 25 the the DT cord-300061-l2pfl776 385 26 manuscript manuscript NN cord-300061-l2pfl776 385 27 . . . cord-300061-l2pfl776 386 1 The the DT cord-300061-l2pfl776 386 2 author author NN cord-300061-l2pfl776 386 3 read read VBD cord-300061-l2pfl776 386 4 and and CC cord-300061-l2pfl776 386 5 approved approve VBD cord-300061-l2pfl776 386 6 the the DT cord-300061-l2pfl776 386 7 final final JJ cord-300061-l2pfl776 386 8 manuscript manuscript NN cord-300061-l2pfl776 386 9 . . . cord-300061-l2pfl776 387 1 The the DT cord-300061-l2pfl776 387 2 author author NN cord-300061-l2pfl776 387 3 declares declare VBZ cord-300061-l2pfl776 387 4 that that IN cord-300061-l2pfl776 387 5 they -PRON- PRP cord-300061-l2pfl776 387 6 have have VBP cord-300061-l2pfl776 387 7 no no DT cord-300061-l2pfl776 387 8 competing compete VBG cord-300061-l2pfl776 387 9 interests interest NNS cord-300061-l2pfl776 387 10 . . . cord-300061-l2pfl776 387 11 _SP