id sid tid token lemma pos cord-298183-cisrvghj 1 1 key key NN cord-298183-cisrvghj 1 2 : : : cord-298183-cisrvghj 1 3 cord-298183-cisrvghj cord-298183-cisrvghj . cord-298183-cisrvghj 2 1 authors author NNS cord-298183-cisrvghj 2 2 : : : cord-298183-cisrvghj 2 3 Fredricks Fredricks NNP cord-298183-cisrvghj 2 4 , , , cord-298183-cisrvghj 2 5 David David NNP cord-298183-cisrvghj 2 6 N N NNP cord-298183-cisrvghj 2 7 ; ; : cord-298183-cisrvghj 2 8 Relman Relman NNP cord-298183-cisrvghj 2 9 , , , cord-298183-cisrvghj 2 10 David David NNP cord-298183-cisrvghj 2 11 A A NNP cord-298183-cisrvghj 3 1 title title NN cord-298183-cisrvghj 3 2 : : : cord-298183-cisrvghj 4 1 The the DT cord-298183-cisrvghj 4 2 infectious infectious JJ cord-298183-cisrvghj 4 3 aetiology aetiology NN cord-298183-cisrvghj 4 4 of of IN cord-298183-cisrvghj 4 5 disease disease NN cord-298183-cisrvghj 4 6 : : : cord-298183-cisrvghj 4 7 the the DT cord-298183-cisrvghj 4 8 search search NN cord-298183-cisrvghj 4 9 for for IN cord-298183-cisrvghj 4 10 new new JJ cord-298183-cisrvghj 4 11 agents agent NNS cord-298183-cisrvghj 4 12 date date NN cord-298183-cisrvghj 4 13 : : : cord-298183-cisrvghj 4 14 2005 2005 CD cord-298183-cisrvghj 4 15 - - HYPH cord-298183-cisrvghj 4 16 03 03 CD cord-298183-cisrvghj 4 17 - - HYPH cord-298183-cisrvghj 4 18 01 01 CD cord-298183-cisrvghj 4 19 journal journal NN cord-298183-cisrvghj 4 20 : : : cord-298183-cisrvghj 4 21 Medicine Medicine NNP cord-298183-cisrvghj 4 22 DOI DOI NNP cord-298183-cisrvghj 4 23 : : : cord-298183-cisrvghj 5 1 10.1383/ 10.1383/ NNP cord-298183-cisrvghj 6 1 medc.33.3.37.61122 medc.33.3.37.61122 NNP cord-298183-cisrvghj 6 2 sha sha NNP cord-298183-cisrvghj 6 3 : : : cord-298183-cisrvghj 7 1 fe09742bd35bce824f16526034e2f3337ed2c90f fe09742bd35bce824f16526034e2f3337ed2c90f CD cord-298183-cisrvghj 7 2 doc_id doc_id CD cord-298183-cisrvghj 8 1 : : : cord-298183-cisrvghj 8 2 298183 298183 CD cord-298183-cisrvghj 8 3 cord_uid cord_uid NNS cord-298183-cisrvghj 8 4 : : : cord-298183-cisrvghj 9 1 cisrvghj cisrvghj NNP cord-298183-cisrvghj 10 1 Abstract Abstract NNP cord-298183-cisrvghj 11 1 There there EX cord-298183-cisrvghj 11 2 are be VBP cord-298183-cisrvghj 11 3 many many JJ cord-298183-cisrvghj 11 4 diseases disease NNS cord-298183-cisrvghj 11 5 for for IN cord-298183-cisrvghj 11 6 which which WDT cord-298183-cisrvghj 11 7 a a DT cord-298183-cisrvghj 11 8 microbial microbial JJ cord-298183-cisrvghj 11 9 aetiology aetiology NN cord-298183-cisrvghj 11 10 is be VBZ cord-298183-cisrvghj 11 11 suspected suspect VBN cord-298183-cisrvghj 11 12 . . . cord-298183-cisrvghj 12 1 The the DT cord-298183-cisrvghj 12 2 hypothesis hypothesis NN cord-298183-cisrvghj 12 3 that that IN cord-298183-cisrvghj 12 4 a a DT cord-298183-cisrvghj 12 5 disease disease NN cord-298183-cisrvghj 12 6 has have VBZ cord-298183-cisrvghj 12 7 an an DT cord-298183-cisrvghj 12 8 infectious infectious JJ cord-298183-cisrvghj 12 9 cause cause NN cord-298183-cisrvghj 12 10 is be VBZ cord-298183-cisrvghj 12 11 supported support VBN cord-298183-cisrvghj 12 12 by by IN cord-298183-cisrvghj 12 13 : : : cord-298183-cisrvghj 12 14 clinical clinical JJ cord-298183-cisrvghj 12 15 features feature NNS cord-298183-cisrvghj 12 16 ( ( -LRB- cord-298183-cisrvghj 12 17 similar similar JJ cord-298183-cisrvghj 12 18 to to IN cord-298183-cisrvghj 12 19 those those DT cord-298183-cisrvghj 12 20 of of IN cord-298183-cisrvghj 12 21 known know VBN cord-298183-cisrvghj 12 22 infectious infectious JJ cord-298183-cisrvghj 12 23 diseases disease NNS cord-298183-cisrvghj 12 24 , , , cord-298183-cisrvghj 12 25 e.g. e.g. RB cord-298183-cisrvghj 12 26 fever fever NN cord-298183-cisrvghj 12 27 , , , cord-298183-cisrvghj 12 28 leucocytosis leucocytosis NNP cord-298183-cisrvghj 12 29 ) ) -RRB- cord-298183-cisrvghj 12 30 , , , cord-298183-cisrvghj 12 31 epidemiology epidemiology NN cord-298183-cisrvghj 12 32 ( ( -LRB- cord-298183-cisrvghj 12 33 case case NN cord-298183-cisrvghj 12 34 clustering cluster VBG cord-298183-cisrvghj 12 35 in in IN cord-298183-cisrvghj 12 36 time time NN cord-298183-cisrvghj 12 37 or or CC cord-298183-cisrvghj 12 38 location location NN cord-298183-cisrvghj 12 39 ) ) -RRB- cord-298183-cisrvghj 12 40 , , , cord-298183-cisrvghj 12 41 histology histology NN cord-298183-cisrvghj 12 42 ( ( -LRB- cord-298183-cisrvghj 12 43 inflammation inflammation NN cord-298183-cisrvghj 12 44 of of IN cord-298183-cisrvghj 12 45 affected affected JJ cord-298183-cisrvghj 12 46 tissues tissue NNS cord-298183-cisrvghj 12 47 , , , cord-298183-cisrvghj 12 48 e.g. e.g. IN cord-298183-cisrvghj 12 49 granulomata granulomata NNP cord-298183-cisrvghj 12 50 ) ) -RRB- cord-298183-cisrvghj 12 51 or or CC cord-298183-cisrvghj 12 52 characteristic characteristic JJ cord-298183-cisrvghj 12 53 microbial microbial JJ cord-298183-cisrvghj 12 54 structures structure NNS cord-298183-cisrvghj 12 55 , , , cord-298183-cisrvghj 12 56 treatment treatment NN cord-298183-cisrvghj 12 57 ( ( -LRB- cord-298183-cisrvghj 12 58 clinical clinical JJ cord-298183-cisrvghj 12 59 response response NN cord-298183-cisrvghj 12 60 to to IN cord-298183-cisrvghj 12 61 antimicrobial antimicrobial JJ cord-298183-cisrvghj 12 62 treatment treatment NN cord-298183-cisrvghj 12 63 ) ) -RRB- cord-298183-cisrvghj 12 64 , , , cord-298183-cisrvghj 12 65 and and CC cord-298183-cisrvghj 12 66 prevention prevention NN cord-298183-cisrvghj 12 67 of of IN cord-298183-cisrvghj 12 68 disease disease NN cord-298183-cisrvghj 12 69 by by IN cord-298183-cisrvghj 12 70 vaccines vaccine NNS cord-298183-cisrvghj 12 71 targeting target VBG cord-298183-cisrvghj 12 72 microbial microbial JJ cord-298183-cisrvghj 12 73 antigens antigen NNS cord-298183-cisrvghj 12 74 . . . cord-298183-cisrvghj 13 1 Proof proof NN cord-298183-cisrvghj 13 2 that that IN cord-298183-cisrvghj 13 3 a a DT cord-298183-cisrvghj 13 4 microbe microbe NN cord-298183-cisrvghj 13 5 causes cause VBZ cord-298183-cisrvghj 13 6 a a DT cord-298183-cisrvghj 13 7 disease disease NN cord-298183-cisrvghj 13 8 requires require VBZ cord-298183-cisrvghj 13 9 more more RBR cord-298183-cisrvghj 13 10 rigorous rigorous JJ cord-298183-cisrvghj 13 11 evidence evidence NN cord-298183-cisrvghj 13 12 . . . cord-298183-cisrvghj 14 1 Future future JJ cord-298183-cisrvghj 14 2 attempts attempt VBZ cord-298183-cisrvghj 14 3 to to TO cord-298183-cisrvghj 14 4 identify identify VB cord-298183-cisrvghj 14 5 novel novel JJ cord-298183-cisrvghj 14 6 microbes microbe NNS cord-298183-cisrvghj 14 7 associated associate VBN cord-298183-cisrvghj 14 8 with with IN cord-298183-cisrvghj 14 9 human human JJ cord-298183-cisrvghj 14 10 disease disease NN cord-298183-cisrvghj 14 11 may may MD cord-298183-cisrvghj 14 12 use use VB cord-298183-cisrvghj 14 13 sequence sequence NN cord-298183-cisrvghj 14 14 - - HYPH cord-298183-cisrvghj 14 15 based base VBN cord-298183-cisrvghj 14 16 approaches approach NNS cord-298183-cisrvghj 14 17 . . . cord-298183-cisrvghj 15 1 High high JJ cord-298183-cisrvghj 15 2 - - HYPH cord-298183-cisrvghj 15 3 throughput throughput NN cord-298183-cisrvghj 15 4 sequencing sequencing NN cord-298183-cisrvghj 15 5 may may MD cord-298183-cisrvghj 15 6 allow allow VB cord-298183-cisrvghj 15 7 identification identification NN cord-298183-cisrvghj 15 8 of of IN cord-298183-cisrvghj 15 9 unique unique JJ cord-298183-cisrvghj 15 10 microbial microbial JJ cord-298183-cisrvghj 15 11 nucleic nucleic JJ cord-298183-cisrvghj 15 12 acid acid NN cord-298183-cisrvghj 15 13 sequences sequence NNS cord-298183-cisrvghj 15 14 in in IN cord-298183-cisrvghj 15 15 a a DT cord-298183-cisrvghj 15 16 background background NN cord-298183-cisrvghj 15 17 of of IN cord-298183-cisrvghj 15 18 host host NN cord-298183-cisrvghj 15 19 DNA dna NN cord-298183-cisrvghj 15 20 . . . cord-298183-cisrvghj 16 1 The the DT cord-298183-cisrvghj 16 2 complete complete JJ cord-298183-cisrvghj 16 3 sequencing sequencing NN cord-298183-cisrvghj 16 4 of of IN cord-298183-cisrvghj 16 5 the the DT cord-298183-cisrvghj 16 6 human human JJ cord-298183-cisrvghj 16 7 genome genome NN cord-298183-cisrvghj 16 8 and and CC cord-298183-cisrvghj 16 9 multiple multiple JJ cord-298183-cisrvghj 16 10 microbial microbial JJ cord-298183-cisrvghj 16 11 genomes genome NNS cord-298183-cisrvghj 16 12 make make VBP cord-298183-cisrvghj 16 13 this this DT cord-298183-cisrvghj 16 14 approach approach NN cord-298183-cisrvghj 16 15 more more RBR cord-298183-cisrvghj 16 16 feasible feasible JJ cord-298183-cisrvghj 16 17 . . . cord-298183-cisrvghj 17 1 DNA dna NN cord-298183-cisrvghj 17 2 microarrays microarray NNS cord-298183-cisrvghj 17 3 are be VBP cord-298183-cisrvghj 17 4 also also RB cord-298183-cisrvghj 17 5 likely likely JJ cord-298183-cisrvghj 17 6 to to TO cord-298183-cisrvghj 17 7 be be VB cord-298183-cisrvghj 17 8 used use VBN cord-298183-cisrvghj 17 9 in in IN cord-298183-cisrvghj 17 10 the the DT cord-298183-cisrvghj 17 11 search search NN cord-298183-cisrvghj 17 12 for for IN cord-298183-cisrvghj 17 13 novel novel JJ cord-298183-cisrvghj 17 14 pathogens pathogen NNS cord-298183-cisrvghj 17 15 . . . cord-298183-cisrvghj 18 1 Just just RB cord-298183-cisrvghj 18 2 when when WRB cord-298183-cisrvghj 18 3 we -PRON- PRP cord-298183-cisrvghj 18 4 think think VBP cord-298183-cisrvghj 18 5 we -PRON- PRP cord-298183-cisrvghj 18 6 have have VBP cord-298183-cisrvghj 18 7 a a DT cord-298183-cisrvghj 18 8 good good JJ cord-298183-cisrvghj 18 9 understanding understanding NN cord-298183-cisrvghj 18 10 of of IN cord-298183-cisrvghj 18 11 the the DT cord-298183-cisrvghj 18 12 microbes microbe NNS cord-298183-cisrvghj 18 13 that that WDT cord-298183-cisrvghj 18 14 occupy occupy VBP cord-298183-cisrvghj 18 15 our -PRON- PRP$ cord-298183-cisrvghj 18 16 planet planet NN cord-298183-cisrvghj 18 17 and and CC cord-298183-cisrvghj 18 18 cause cause VB cord-298183-cisrvghj 18 19 disease disease NN cord-298183-cisrvghj 18 20 , , , cord-298183-cisrvghj 18 21 nature nature NN cord-298183-cisrvghj 18 22 reminds remind VBZ cord-298183-cisrvghj 18 23 us -PRON- PRP cord-298183-cisrvghj 18 24 that that IN cord-298183-cisrvghj 18 25 our -PRON- PRP$ cord-298183-cisrvghj 18 26 knowledge knowledge NN cord-298183-cisrvghj 18 27 is be VBZ cord-298183-cisrvghj 18 28 incomplete incomplete JJ cord-298183-cisrvghj 18 29 . . . cord-298183-cisrvghj 19 1 In in IN cord-298183-cisrvghj 19 2 the the DT cord-298183-cisrvghj 19 3 last last JJ cord-298183-cisrvghj 19 4 few few JJ cord-298183-cisrvghj 19 5 decades decade NNS cord-298183-cisrvghj 19 6 , , , cord-298183-cisrvghj 19 7 a a DT cord-298183-cisrvghj 19 8 novel novel JJ cord-298183-cisrvghj 19 9 retrovirus retrovirus NN cord-298183-cisrvghj 19 10 ( ( -LRB- cord-298183-cisrvghj 19 11 HIV HIV NNP cord-298183-cisrvghj 19 12 ) ) -RRB- cord-298183-cisrvghj 19 13 has have VBZ cord-298183-cisrvghj 19 14 emerged emerge VBN cord-298183-cisrvghj 19 15 from from IN cord-298183-cisrvghj 19 16 the the DT cord-298183-cisrvghj 19 17 jungles jungle NNS cord-298183-cisrvghj 19 18 of of IN cord-298183-cisrvghj 19 19 Africa Africa NNP cord-298183-cisrvghj 19 20 to to TO cord-298183-cisrvghj 19 21 infect infect VB cord-298183-cisrvghj 19 22 and and CC cord-298183-cisrvghj 19 23 kill kill VB cord-298183-cisrvghj 19 24 millions million NNS cord-298183-cisrvghj 19 25 of of IN cord-298183-cisrvghj 19 26 individuals individual NNS cord-298183-cisrvghj 19 27 from from IN cord-298183-cisrvghj 19 28 all all DT cord-298183-cisrvghj 19 29 continents continent NNS cord-298183-cisrvghj 19 30 . . . cord-298183-cisrvghj 20 1 Less less RBR cord-298183-cisrvghj 20 2 dramatically dramatically RB cord-298183-cisrvghj 20 3 , , , cord-298183-cisrvghj 20 4 newly newly RB cord-298183-cisrvghj 20 5 described describe VBN cord-298183-cisrvghj 20 6 microbes microbe NNS cord-298183-cisrvghj 20 7 have have VBP cord-298183-cisrvghj 20 8 been be VBN cord-298183-cisrvghj 20 9 linked link VBN cord-298183-cisrvghj 20 10 to to IN cord-298183-cisrvghj 20 11 human human JJ cord-298183-cisrvghj 20 12 diseases disease NNS cord-298183-cisrvghj 20 13 since since IN cord-298183-cisrvghj 20 14 1980 1980 CD cord-298183-cisrvghj 21 1 ( ( -LRB- cord-298183-cisrvghj 21 2 Figure figure NN cord-298183-cisrvghj 21 3 1 1 CD cord-298183-cisrvghj 21 4 ) ) -RRB- cord-298183-cisrvghj 21 5 . . . cord-298183-cisrvghj 22 1 Are be VBP cord-298183-cisrvghj 22 2 there there EX cord-298183-cisrvghj 22 3 other other JJ cord-298183-cisrvghj 22 4 microbial microbial JJ cord-298183-cisrvghj 22 5 pathogens pathogen NNS cord-298183-cisrvghj 22 6 that that WDT cord-298183-cisrvghj 22 7 are be VBP cord-298183-cisrvghj 22 8 significant significant JJ cord-298183-cisrvghj 22 9 causes cause NNS cord-298183-cisrvghj 22 10 of of IN cord-298183-cisrvghj 22 11 human human JJ cord-298183-cisrvghj 22 12 disease disease NN cord-298183-cisrvghj 22 13 and and CC cord-298183-cisrvghj 22 14 await await VBP cord-298183-cisrvghj 22 15 discovery discovery NN cord-298183-cisrvghj 22 16 ? ? . cord-298183-cisrvghj 23 1 There there EX cord-298183-cisrvghj 23 2 are be VBP cord-298183-cisrvghj 23 3 many many JJ cord-298183-cisrvghj 23 4 diseases disease NNS cord-298183-cisrvghj 23 5 for for IN cord-298183-cisrvghj 23 6 which which WDT cord-298183-cisrvghj 23 7 a a DT cord-298183-cisrvghj 23 8 microbial microbial JJ cord-298183-cisrvghj 23 9 aetiology aetiology NN cord-298183-cisrvghj 23 10 is be VBZ cord-298183-cisrvghj 23 11 suspected suspect VBN cord-298183-cisrvghj 23 12 ( ( -LRB- cord-298183-cisrvghj 23 13 Figure figure NN cord-298183-cisrvghj 23 14 2 2 CD cord-298183-cisrvghj 23 15 ) ) -RRB- cord-298183-cisrvghj 23 16 . . . cord-298183-cisrvghj 24 1 The the DT cord-298183-cisrvghj 24 2 hypothesis hypothesis NN cord-298183-cisrvghj 24 3 that that IN cord-298183-cisrvghj 24 4 a a DT cord-298183-cisrvghj 24 5 disease disease NN cord-298183-cisrvghj 24 6 has have VBZ cord-298183-cisrvghj 24 7 an an DT cord-298183-cisrvghj 24 8 infectious infectious JJ cord-298183-cisrvghj 24 9 cause cause NN cord-298183-cisrvghj 24 10 is be VBZ cord-298183-cisrvghj 24 11 supported support VBN cord-298183-cisrvghj 24 12 by by IN cord-298183-cisrvghj 24 13 : : : cord-298183-cisrvghj 24 14 • • NNP cord-298183-cisrvghj 24 15 clinical clinical JJ cord-298183-cisrvghj 24 16 features feature NNS cord-298183-cisrvghj 24 17 -similar -similar JJ cord-298183-cisrvghj 24 18 to to IN cord-298183-cisrvghj 24 19 those those DT cord-298183-cisrvghj 24 20 of of IN cord-298183-cisrvghj 24 21 known know VBN cord-298183-cisrvghj 24 22 infectious infectious JJ cord-298183-cisrvghj 24 23 diseases disease NNS cord-298183-cisrvghj 24 24 ( ( -LRB- cord-298183-cisrvghj 24 25 e.g. e.g. RB cord-298183-cisrvghj 24 26 fever fever NN cord-298183-cisrvghj 24 27 , , , cord-298183-cisrvghj 24 28 leucocytosis leucocytosis NNP cord-298183-cisrvghj 24 29 ) ) -RRB- cord-298183-cisrvghj 25 1 • • NNP cord-298183-cisrvghj 26 1 epidemiology epidemiology NN cord-298183-cisrvghj 26 2 -case -case NN cord-298183-cisrvghj 26 3 clustering clustering NN cord-298183-cisrvghj 26 4 in in IN cord-298183-cisrvghj 26 5 time time NN cord-298183-cisrvghj 26 6 or or CC cord-298183-cisrvghj 26 7 location location NN cord-298183-cisrvghj 27 1 • • NNP cord-298183-cisrvghj 28 1 histology histology NN cord-298183-cisrvghj 28 2 -inflammation -inflammation NN cord-298183-cisrvghj 28 3 of of IN cord-298183-cisrvghj 28 4 affected affect VBN cord-298183-cisrvghj 28 5 tissues tissue NNS cord-298183-cisrvghj 28 6 ( ( -LRB- cord-298183-cisrvghj 28 7 e.g. e.g. RB cord-298183-cisrvghj 28 8 granulomata granulomata NNP cord-298183-cisrvghj 28 9 ) ) -RRB- cord-298183-cisrvghj 28 10 or or CC cord-298183-cisrvghj 28 11 characteristic characteristic JJ cord-298183-cisrvghj 28 12 microbial microbial JJ cord-298183-cisrvghj 28 13 structures structure NNS cord-298183-cisrvghj 29 1 • • NNP cord-298183-cisrvghj 30 1 treatment treatment NN cord-298183-cisrvghj 30 2 -a -a HYPH cord-298183-cisrvghj 30 3 clinical clinical JJ cord-298183-cisrvghj 30 4 response response NN cord-298183-cisrvghj 30 5 to to IN cord-298183-cisrvghj 30 6 antimicrobial antimicrobial JJ cord-298183-cisrvghj 30 7 treatment treatment NN cord-298183-cisrvghj 30 8 • • NNP cord-298183-cisrvghj 30 9 prevention prevention NN cord-298183-cisrvghj 30 10 of of IN cord-298183-cisrvghj 30 11 disease disease NN cord-298183-cisrvghj 30 12 by by IN cord-298183-cisrvghj 30 13 vaccines vaccine NNS cord-298183-cisrvghj 30 14 targeting target VBG cord-298183-cisrvghj 30 15 microbial microbial JJ cord-298183-cisrvghj 30 16 antigens antigen NNS cord-298183-cisrvghj 30 17 . . . cord-298183-cisrvghj 31 1 Proof proof NN cord-298183-cisrvghj 31 2 that that IN cord-298183-cisrvghj 31 3 a a DT cord-298183-cisrvghj 31 4 microbe microbe NN cord-298183-cisrvghj 31 5 causes cause VBZ cord-298183-cisrvghj 31 6 a a DT cord-298183-cisrvghj 31 7 disease disease NN cord-298183-cisrvghj 31 8 requires require VBZ cord-298183-cisrvghj 31 9 more more RBR cord-298183-cisrvghj 31 10 rigorous rigorous JJ cord-298183-cisrvghj 31 11 evidence evidence NN cord-298183-cisrvghj 31 12 . . . cord-298183-cisrvghj 32 1 If if IN cord-298183-cisrvghj 32 2 microbes microbe NNS cord-298183-cisrvghj 32 3 are be VBP cord-298183-cisrvghj 32 4 the the DT cord-298183-cisrvghj 32 5 cause cause NN cord-298183-cisrvghj 32 6 of of IN cord-298183-cisrvghj 32 7 some some DT cord-298183-cisrvghj 32 8 idiopathic idiopathic JJ cord-298183-cisrvghj 32 9 diseases disease NNS cord-298183-cisrvghj 32 10 , , , cord-298183-cisrvghj 32 11 why why WRB cord-298183-cisrvghj 32 12 have have VBP cord-298183-cisrvghj 32 13 we -PRON- PRP cord-298183-cisrvghj 32 14 not not RB cord-298183-cisrvghj 32 15 discovered discover VBN cord-298183-cisrvghj 32 16 them -PRON- PRP cord-298183-cisrvghj 32 17 yet yet RB cord-298183-cisrvghj 32 18 ? ? . cord-298183-cisrvghj 33 1 • • NNP cord-298183-cisrvghj 33 2 One one CD cord-298183-cisrvghj 33 3 reason reason NN cord-298183-cisrvghj 33 4 is be VBZ cord-298183-cisrvghj 33 5 failure failure NN cord-298183-cisrvghj 33 6 to to TO cord-298183-cisrvghj 33 7 consider consider VB cord-298183-cisrvghj 33 8 the the DT cord-298183-cisrvghj 33 9 hypothesis hypothesis NN cord-298183-cisrvghj 33 10 of of IN cord-298183-cisrvghj 33 11 infection infection NN cord-298183-cisrvghj 33 12 . . . cord-298183-cisrvghj 34 1 The the DT cord-298183-cisrvghj 34 2 association association NN cord-298183-cisrvghj 34 3 between between IN cord-298183-cisrvghj 34 4 Helicobacter Helicobacter NNP cord-298183-cisrvghj 34 5 pylori pylori NN cord-298183-cisrvghj 34 6 infection infection NN cord-298183-cisrvghj 34 7 and and CC cord-298183-cisrvghj 34 8 peptic peptic JJ cord-298183-cisrvghj 34 9 ulcer ulcer NN cord-298183-cisrvghj 34 10 disease disease NN cord-298183-cisrvghj 34 11 was be VBD cord-298183-cisrvghj 34 12 not not RB cord-298183-cisrvghj 34 13 made make VBN cord-298183-cisrvghj 34 14 until until IN cord-298183-cisrvghj 34 15 recently recently RB cord-298183-cisrvghj 34 16 , , , cord-298183-cisrvghj 34 17 despite despite IN cord-298183-cisrvghj 34 18 our -PRON- PRP$ cord-298183-cisrvghj 34 19 ability ability NN cord-298183-cisrvghj 34 20 to to TO cord-298183-cisrvghj 34 21 cultivate cultivate VB cord-298183-cisrvghj 34 22 this this DT cord-298183-cisrvghj 34 23 bacterium bacterium NN cord-298183-cisrvghj 34 24 in in IN cord-298183-cisrvghj 34 25 the the DT cord-298183-cisrvghj 34 26 laboratory laboratory NN cord-298183-cisrvghj 34 27 and and CC cord-298183-cisrvghj 34 28 to to TO cord-298183-cisrvghj 34 29 see see VB cord-298183-cisrvghj 34 30 it -PRON- PRP cord-298183-cisrvghj 34 31 under under IN cord-298183-cisrvghj 34 32 the the DT cord-298183-cisrvghj 34 33 microscope microscope NN cord-298183-cisrvghj 34 34 in in IN cord-298183-cisrvghj 34 35 gastric gastric JJ cord-298183-cisrvghj 34 36 biopsies biopsy NNS cord-298183-cisrvghj 34 37 . . . cord-298183-cisrvghj 35 1 • • NNP cord-298183-cisrvghj 36 1 Another another DT cord-298183-cisrvghj 36 2 reason reason NN cord-298183-cisrvghj 36 3 is be VBZ cord-298183-cisrvghj 36 4 failure failure NN cord-298183-cisrvghj 36 5 of of IN cord-298183-cisrvghj 36 6 conventional conventional JJ cord-298183-cisrvghj 36 7 microbial microbial JJ cord-298183-cisrvghj 36 8 detection detection NN cord-298183-cisrvghj 36 9 technologies technology NNS cord-298183-cisrvghj 36 10 . . . cord-298183-cisrvghj 37 1 Studies study NNS cord-298183-cisrvghj 37 2 of of IN cord-298183-cisrvghj 37 3 bacterial bacterial JJ cord-298183-cisrvghj 37 4 biodiversity biodiversity NN cord-298183-cisrvghj 37 5 in in IN cord-298183-cisrvghj 37 6 various various JJ cord-298183-cisrvghj 37 7 envi- envi- NN cord-298183-cisrvghj 37 8 ronmental ronmental NNP cord-298183-cisrvghj 37 9 and and CC cord-298183-cisrvghj 37 10 human human JJ cord-298183-cisrvghj 37 11 niches niche NNS cord-298183-cisrvghj 37 12 have have VBP cord-298183-cisrvghj 37 13 shown show VBN cord-298183-cisrvghj 37 14 that that IN cord-298183-cisrvghj 37 15 cultivation cultivation NN cord-298183-cisrvghj 37 16 can can MD cord-298183-cisrvghj 37 17 detect detect VB cord-298183-cisrvghj 37 18 only only RB cord-298183-cisrvghj 37 19 a a DT cord-298183-cisrvghj 37 20 fraction fraction NN cord-298183-cisrvghj 37 21 of of IN cord-298183-cisrvghj 37 22 the the DT cord-298183-cisrvghj 37 23 bacteria bacteria NNS cord-298183-cisrvghj 37 24 identified identify VBN cord-298183-cisrvghj 37 25 using use VBG cord-298183-cisrvghj 37 26 nucleic nucleic JJ cord-298183-cisrvghj 37 27 acid acid NN cord-298183-cisrvghj 37 28 sequences sequence NNS cord-298183-cisrvghj 37 29 . . . cord-298183-cisrvghj 38 1 Microbes microbe NNS cord-298183-cisrvghj 38 2 may may MD cord-298183-cisrvghj 38 3 exist exist VB cord-298183-cisrvghj 38 4 in in IN cord-298183-cisrvghj 38 5 viable viable JJ cord-298183-cisrvghj 38 6 but but CC cord-298183-cisrvghj 38 7 non non JJ cord-298183-cisrvghj 38 8 - - JJ cord-298183-cisrvghj 38 9 culturable culturable JJ cord-298183-cisrvghj 38 10 states state NNS cord-298183-cisrvghj 38 11 , , , cord-298183-cisrvghj 38 12 or or CC cord-298183-cisrvghj 38 13 as as IN cord-298183-cisrvghj 38 14 sessile sessile JJ cord-298183-cisrvghj 38 15 members member NNS cord-298183-cisrvghj 38 16 of of IN cord-298183-cisrvghj 38 17 biofilm biofilm NN cord-298183-cisrvghj 38 18 communities community NNS cord-298183-cisrvghj 38 19 in in IN cord-298183-cisrvghj 38 20 which which WDT cord-298183-cisrvghj 38 21 individual individual JJ cord-298183-cisrvghj 38 22 cells cell NNS cord-298183-cisrvghj 38 23 may may MD cord-298183-cisrvghj 38 24 be be VB cord-298183-cisrvghj 38 25 difficult difficult JJ cord-298183-cisrvghj 38 26 to to TO cord-298183-cisrvghj 38 27 cultivate cultivate VB cord-298183-cisrvghj 38 28 . . . cord-298183-cisrvghj 39 1 Accordingly accordingly RB cord-298183-cisrvghj 39 2 , , , cord-298183-cisrvghj 39 3 failure failure NN cord-298183-cisrvghj 39 4 to to TO cord-298183-cisrvghj 39 5 propagate propagate VB cord-298183-cisrvghj 39 6 a a DT cord-298183-cisrvghj 39 7 microbe microbe NN cord-298183-cisrvghj 39 8 in in IN cord-298183-cisrvghj 39 9 the the DT cord-298183-cisrvghj 39 10 laboratory laboratory NN cord-298183-cisrvghj 39 11 does do VBZ cord-298183-cisrvghj 39 12 not not RB cord-298183-cisrvghj 39 13 mean mean VB cord-298183-cisrvghj 39 14 that that IN cord-298183-cisrvghj 39 15 the the DT cord-298183-cisrvghj 39 16 sample sample NN cord-298183-cisrvghj 39 17 is be VBZ cord-298183-cisrvghj 39 18 free free JJ cord-298183-cisrvghj 39 19 of of IN cord-298183-cisrvghj 39 20 microbes microbe NNS cord-298183-cisrvghj 39 21 . . . cord-298183-cisrvghj 40 1 • • NNP cord-298183-cisrvghj 41 1 Microbes microbe NNS cord-298183-cisrvghj 41 2 may may MD cord-298183-cisrvghj 41 3 evade evade VB cord-298183-cisrvghj 41 4 detection detection NN cord-298183-cisrvghj 41 5 through through IN cord-298183-cisrvghj 41 6 a a DT cord-298183-cisrvghj 41 7 pathogenic pathogenic JJ cord-298183-cisrvghj 41 8 process process NN cord-298183-cisrvghj 41 9 of of IN cord-298183-cisrvghj 41 10 ' ' `` cord-298183-cisrvghj 41 11 hit hit VB cord-298183-cisrvghj 41 12 and and CC cord-298183-cisrvghj 41 13 run run VB cord-298183-cisrvghj 41 14 ' ' '' cord-298183-cisrvghj 41 15 . . . cord-298183-cisrvghj 42 1 Organisms organism NNS cord-298183-cisrvghj 42 2 such such JJ cord-298183-cisrvghj 42 3 as as IN cord-298183-cisrvghj 42 4 Streptococcus streptococcus NN cord-298183-cisrvghj 42 5 pyogenes pyogene NNS cord-298183-cisrvghj 42 6 may may MD cord-298183-cisrvghj 42 7 initiate initiate VB cord-298183-cisrvghj 42 8 an an DT cord-298183-cisrvghj 42 9 immunological immunological JJ cord-298183-cisrvghj 42 10 response response NN cord-298183-cisrvghj 42 11 that that WDT cord-298183-cisrvghj 42 12 continues continue VBZ cord-298183-cisrvghj 42 13 to to TO cord-298183-cisrvghj 42 14 cause cause VB cord-298183-cisrvghj 42 15 disease disease NN cord-298183-cisrvghj 42 16 long long RB cord-298183-cisrvghj 42 17 after after IN cord-298183-cisrvghj 42 18 the the DT cord-298183-cisrvghj 42 19 microbe microbe NN cord-298183-cisrvghj 42 20 is be VBZ cord-298183-cisrvghj 42 21 eradicated eradicate VBN cord-298183-cisrvghj 42 22 ( ( -LRB- cord-298183-cisrvghj 42 23 rheumatic rheumatic JJ cord-298183-cisrvghj 42 24 fever fever NN cord-298183-cisrvghj 42 25 ) ) -RRB- cord-298183-cisrvghj 42 26 . . . cord-298183-cisrvghj 43 1 • • NNP cord-298183-cisrvghj 44 1 Ubiquitous ubiquitous JJ cord-298183-cisrvghj 44 2 microbes microbe NNS cord-298183-cisrvghj 44 3 can can MD cord-298183-cisrvghj 44 4 cause cause VB cord-298183-cisrvghj 44 5 rare rare JJ cord-298183-cisrvghj 44 6 diseases disease NNS cord-298183-cisrvghj 44 7 as as IN cord-298183-cisrvghj 44 8 a a DT cord-298183-cisrvghj 44 9 result result NN cord-298183-cisrvghj 44 10 of of IN cord-298183-cisrvghj 44 11 aberrant aberrant JJ cord-298183-cisrvghj 44 12 host host NN cord-298183-cisrvghj 44 13 responses response NNS cord-298183-cisrvghj 44 14 . . . cord-298183-cisrvghj 45 1 When when WRB cord-298183-cisrvghj 45 2 a a DT cord-298183-cisrvghj 45 3 common common JJ cord-298183-cisrvghj 45 4 virus virus NN cord-298183-cisrvghj 45 5 causes cause VBZ cord-298183-cisrvghj 45 6 a a DT cord-298183-cisrvghj 45 7 rare rare JJ cord-298183-cisrvghj 45 8 neurological neurological JJ cord-298183-cisrvghj 45 9 disease disease NN cord-298183-cisrvghj 45 10 in in IN cord-298183-cisrvghj 45 11 a a DT cord-298183-cisrvghj 45 12 small small JJ cord-298183-cisrvghj 45 13 subset subset NN cord-298183-cisrvghj 45 14 of of IN cord-298183-cisrvghj 45 15 susceptible susceptible JJ cord-298183-cisrvghj 45 16 hosts host NNS cord-298183-cisrvghj 45 17 , , , cord-298183-cisrvghj 45 18 for for IN cord-298183-cisrvghj 45 19 example example NN cord-298183-cisrvghj 45 20 , , , cord-298183-cisrvghj 45 21 it -PRON- PRP cord-298183-cisrvghj 45 22 is be VBZ cord-298183-cisrvghj 45 23 difficult difficult JJ cord-298183-cisrvghj 45 24 to to TO cord-298183-cisrvghj 45 25 make make VB cord-298183-cisrvghj 45 26 an an DT cord-298183-cisrvghj 45 27 association association NN cord-298183-cisrvghj 45 28 . . . cord-298183-cisrvghj 46 1 Infection infection NN cord-298183-cisrvghj 46 2 with with IN cord-298183-cisrvghj 46 3 the the DT cord-298183-cisrvghj 46 4 Some some DT cord-298183-cisrvghj 46 5 micro micro JJ cord-298183-cisrvghj 46 6 - - HYPH cord-298183-cisrvghj 46 7 organisms organism NNS cord-298183-cisrvghj 46 8 described describe VBN cord-298183-cisrvghj 46 9 since since IN cord-298183-cisrvghj 46 10 1980 1980 CD cord-298183-cisrvghj 46 11 and and CC cord-298183-cisrvghj 46 12 the the DT cord-298183-cisrvghj 46 13 diseases disease NNS cord-298183-cisrvghj 46 14 they -PRON- PRP cord-298183-cisrvghj 46 15 cause cause VBP cord-298183-cisrvghj 46 16 _SP cord-298183-cisrvghj 46 17 Many many JJ cord-298183-cisrvghj 46 18 of of IN cord-298183-cisrvghj 46 19 the the DT cord-298183-cisrvghj 46 20 recently recently RB cord-298183-cisrvghj 46 21 discovered discover VBN cord-298183-cisrvghj 46 22 microbial microbial JJ cord-298183-cisrvghj 46 23 pathogens pathogen NNS cord-298183-cisrvghj 46 24 were be VBD cord-298183-cisrvghj 46 25 identified identify VBN cord-298183-cisrvghj 46 26 by by IN cord-298183-cisrvghj 46 27 detecting detect VBG cord-298183-cisrvghj 46 28 their -PRON- PRP$ cord-298183-cisrvghj 46 29 unique unique JJ cord-298183-cisrvghj 46 30 nucleic nucleic JJ cord-298183-cisrvghj 46 31 acid acid NN cord-298183-cisrvghj 46 32 sequences sequence NNS cord-298183-cisrvghj 46 33 in in IN cord-298183-cisrvghj 46 34 tissues tissue NNS cord-298183-cisrvghj 46 35 . . . cord-298183-cisrvghj 47 1 An an DT cord-298183-cisrvghj 47 2 example example NN cord-298183-cisrvghj 47 3 of of IN cord-298183-cisrvghj 47 4 this this DT cord-298183-cisrvghj 47 5 approach approach NN cord-298183-cisrvghj 47 6 is be VBZ cord-298183-cisrvghj 47 7 the the DT cord-298183-cisrvghj 47 8 discovery discovery NN cord-298183-cisrvghj 47 9 of of IN cord-298183-cisrvghj 47 10 Bartonella Bartonella NNP cord-298183-cisrvghj 47 11 as as IN cord-298183-cisrvghj 47 12 the the DT cord-298183-cisrvghj 47 13 a a DT cord-298183-cisrvghj 47 14 cause cause NN cord-298183-cisrvghj 47 15 of of IN cord-298183-cisrvghj 47 16 bacillary bacillary NNP cord-298183-cisrvghj 47 17 angiomatosis angiomatosis NNP cord-298183-cisrvghj 47 18 . . . cord-298183-cisrvghj 48 1 Although although IN cord-298183-cisrvghj 48 2 bacterial bacterial JJ cord-298183-cisrvghj 48 3 structures structure NNS cord-298183-cisrvghj 48 4 are be VBP cord-298183-cisrvghj 48 5 visible visible JJ cord-298183-cisrvghj 48 6 in in IN cord-298183-cisrvghj 48 7 bacillary bacillary JJ cord-298183-cisrvghj 48 8 angiomatosis angiomatosis NNP cord-298183-cisrvghj 48 9 tissues tissue NNS cord-298183-cisrvghj 48 10 , , , cord-298183-cisrvghj 48 11 a a DT cord-298183-cisrvghj 48 12 cultivated cultivate VBN cord-298183-cisrvghj 48 13 bacterium bacterium NN cord-298183-cisrvghj 48 14 was be VBD cord-298183-cisrvghj 48 15 not not RB cord-298183-cisrvghj 48 16 initially initially RB cord-298183-cisrvghj 48 17 apparent apparent JJ cord-298183-cisrvghj 48 18 . . . cord-298183-cisrvghj 49 1 Oligonucleotide oligonucleotide JJ cord-298183-cisrvghj 49 2 primers primer NNS cord-298183-cisrvghj 49 3 complementary complementary JJ cord-298183-cisrvghj 49 4 to to IN cord-298183-cisrvghj 49 5 highly highly RB cord-298183-cisrvghj 49 6 conserved conserved JJ cord-298183-cisrvghj 49 7 sequences sequence NNS cord-298183-cisrvghj 49 8 in in IN cord-298183-cisrvghj 49 9 known know VBN cord-298183-cisrvghj 49 10 bacterial bacterial JJ cord-298183-cisrvghj 49 11 16S 16S NNPS cord-298183-cisrvghj 49 12 rRNA rrna NN cord-298183-cisrvghj 49 13 genes gene NNS cord-298183-cisrvghj 49 14 were be VBD cord-298183-cisrvghj 49 15 used use VBN cord-298183-cisrvghj 49 16 in in IN cord-298183-cisrvghj 49 17 a a DT cord-298183-cisrvghj 49 18 polymerase polymerase NN cord-298183-cisrvghj 49 19 chain chain NN cord-298183-cisrvghj 49 20 reaction reaction NN cord-298183-cisrvghj 49 21 ( ( -LRB- cord-298183-cisrvghj 49 22 PCR PCR NNP cord-298183-cisrvghj 49 23 ) ) -RRB- cord-298183-cisrvghj 49 24 to to TO cord-298183-cisrvghj 49 25 amplify amplify VB cord-298183-cisrvghj 49 26 small small JJ cord-298183-cisrvghj 49 27 quantities quantity NNS cord-298183-cisrvghj 49 28 of of IN cord-298183-cisrvghj 49 29 bacterial bacterial JJ cord-298183-cisrvghj 49 30 DNA dna NN cord-298183-cisrvghj 49 31 present present NN cord-298183-cisrvghj 49 32 in in IN cord-298183-cisrvghj 49 33 bacillary bacillary NNP cord-298183-cisrvghj 49 34 angiomatosis angiomatosis NN cord-298183-cisrvghj 49 35 tissues tissue NNS cord-298183-cisrvghj 49 36 . . . cord-298183-cisrvghj 50 1 1 1 LS cord-298183-cisrvghj 51 1 The the DT cord-298183-cisrvghj 51 2 16S 16S NNP cord-298183-cisrvghj 51 3 rRNA rRNA NNP cord-298183-cisrvghj 51 4 gene gene NN cord-298183-cisrvghj 51 5 also also RB cord-298183-cisrvghj 51 6 contains contain VBZ cord-298183-cisrvghj 51 7 regions region NNS cord-298183-cisrvghj 51 8 of of IN cord-298183-cisrvghj 51 9 sequence sequence NN cord-298183-cisrvghj 51 10 variability variability NN cord-298183-cisrvghj 51 11 that that WDT cord-298183-cisrvghj 51 12 , , , cord-298183-cisrvghj 51 13 when when WRB cord-298183-cisrvghj 51 14 amplified amplify VBN cord-298183-cisrvghj 51 15 using use VBG cord-298183-cisrvghj 51 16 this this DT cord-298183-cisrvghj 51 17 consensus consensus NN cord-298183-cisrvghj 51 18 PCR PCR NNP cord-298183-cisrvghj 51 19 approach approach NN cord-298183-cisrvghj 51 20 , , , cord-298183-cisrvghj 51 21 can can MD cord-298183-cisrvghj 51 22 be be VB cord-298183-cisrvghj 51 23 used use VBN cord-298183-cisrvghj 51 24 to to TO cord-298183-cisrvghj 51 25 identify identify VB cord-298183-cisrvghj 51 26 the the DT cord-298183-cisrvghj 51 27 bacteria bacteria NNS cord-298183-cisrvghj 51 28 or or CC cord-298183-cisrvghj 51 29 to to TO cord-298183-cisrvghj 51 30 infer infer VB cord-298183-cisrvghj 51 31 evolutionary evolutionary JJ cord-298183-cisrvghj 51 32 relationships relationship NNS cord-298183-cisrvghj 51 33 to to IN cord-298183-cisrvghj 51 34 other other JJ cord-298183-cisrvghj 51 35 bacteria bacteria NNS cord-298183-cisrvghj 51 36 . . . cord-298183-cisrvghj 52 1 A a DT cord-298183-cisrvghj 52 2 unique unique JJ cord-298183-cisrvghj 52 3 16S 16s JJ cord-298183-cisrvghj 52 4 rDNA rdna NN cord-298183-cisrvghj 52 5 sequence sequence NN cord-298183-cisrvghj 52 6 was be VBD cord-298183-cisrvghj 52 7 detected detect VBN cord-298183-cisrvghj 52 8 in in IN cord-298183-cisrvghj 52 9 the the DT cord-298183-cisrvghj 52 10 tissues tissue NNS cord-298183-cisrvghj 52 11 of of IN cord-298183-cisrvghj 52 12 three three CD cord-298183-cisrvghj 52 13 patients patient NNS cord-298183-cisrvghj 52 14 with with IN cord-298183-cisrvghj 52 15 bacillary bacillary NNP cord-298183-cisrvghj 52 16 angiomatosis angiomatosis NNP cord-298183-cisrvghj 52 17 but but CC cord-298183-cisrvghj 52 18 not not RB cord-298183-cisrvghj 52 19 in in IN cord-298183-cisrvghj 52 20 control control NN cord-298183-cisrvghj 52 21 tissues tissue NNS cord-298183-cisrvghj 52 22 , , , cord-298183-cisrvghj 52 23 identifying identify VBG cord-298183-cisrvghj 52 24 a a DT cord-298183-cisrvghj 52 25 bacterium bacterium NN cord-298183-cisrvghj 52 26 in in IN cord-298183-cisrvghj 52 27 the the DT cord-298183-cisrvghj 52 28 Bartonella Bartonella NNP cord-298183-cisrvghj 52 29 genus genus NN cord-298183-cisrvghj 52 30 as as IN cord-298183-cisrvghj 52 31 a a DT cord-298183-cisrvghj 52 32 cause cause NN cord-298183-cisrvghj 52 33 of of IN cord-298183-cisrvghj 52 34 a a DT cord-298183-cisrvghj 52 35 the the DT cord-298183-cisrvghj 52 36 disease disease NN cord-298183-cisrvghj 52 37 . . . cord-298183-cisrvghj 53 1 This this DT cord-298183-cisrvghj 53 2 organism organism NN cord-298183-cisrvghj 53 3 was be VBD cord-298183-cisrvghj 53 4 later later RB cord-298183-cisrvghj 53 5 named name VBN cord-298183-cisrvghj 53 6 Bartonella Bartonella NNP cord-298183-cisrvghj 53 7 henselae henselae NNP cord-298183-cisrvghj 53 8 . . . cord-298183-cisrvghj 54 1 B. B. NNP cord-298183-cisrvghj 54 2 quintana quintana NNP cord-298183-cisrvghj 54 3 is be VBZ cord-298183-cisrvghj 54 4 another another DT cord-298183-cisrvghj 54 5 cause cause NN cord-298183-cisrvghj 54 6 of of IN cord-298183-cisrvghj 54 7 bacillary bacillary NNP cord-298183-cisrvghj 54 8 angiomatosis angiomatosis NNP cord-298183-cisrvghj 54 9 , , , cord-298183-cisrvghj 54 10 and and CC cord-298183-cisrvghj 54 11 also also RB cord-298183-cisrvghj 54 12 a a DT cord-298183-cisrvghj 54 13 causes cause NNS cord-298183-cisrvghj 54 14 trench trench NN cord-298183-cisrvghj 54 15 fever fever NN cord-298183-cisrvghj 54 16 and and CC cord-298183-cisrvghj 54 17 endocarditis endocarditis NN cord-298183-cisrvghj 54 18 , , , cord-298183-cisrvghj 54 19 and and CC cord-298183-cisrvghj 54 20 B. B. NNP cord-298183-cisrvghj 54 21 henselae henselae NNP cord-298183-cisrvghj 54 22 is be VBZ cord-298183-cisrvghj 54 23 responsible responsible JJ cord-298183-cisrvghj 54 24 e e XX cord-298183-cisrvghj 54 25 for for IN cord-298183-cisrvghj 54 26 cat cat NN cord-298183-cisrvghj 54 27 - - HYPH cord-298183-cisrvghj 54 28 scratch scratch NN cord-298183-cisrvghj 54 29 disease disease NN cord-298183-cisrvghj 54 30 in in IN cord-298183-cisrvghj 54 31 immunocompetent immunocompetent JJ cord-298183-cisrvghj 54 32 hosts host NNS cord-298183-cisrvghj 54 33 . . . cord-298183-cisrvghj 55 1 B. B. NNP cord-298183-cisrvghj 55 2 bacilliformis bacilliformis NNP cord-298183-cisrvghj 55 3 ( ( -LRB- cord-298183-cisrvghj 55 4 Oroya Oroya NNP cord-298183-cisrvghj 55 5 fever fever NN cord-298183-cisrvghj 55 6 , , , cord-298183-cisrvghj 55 7 verruga verruga NNP cord-298183-cisrvghj 55 8 peruana peruana NNP cord-298183-cisrvghj 55 9 ) ) -RRB- cord-298183-cisrvghj 55 10 and and CC cord-298183-cisrvghj 55 11 B. B. NNP cord-298183-cisrvghj 55 12 elizabethae elizabethae NNS cord-298183-cisrvghj 55 13 ( ( -LRB- cord-298183-cisrvghj 55 14 endocarditis endocarditis NN cord-298183-cisrvghj 55 15 ) ) -RRB- cord-298183-cisrvghj 56 1 e e NNP cord-298183-cisrvghj 56 2 are be VBP cord-298183-cisrvghj 56 3 also also RB cord-298183-cisrvghj 56 4 human human JJ cord-298183-cisrvghj 56 5 pathogens pathogen NNS cord-298183-cisrvghj 56 6 . . . cord-298183-cisrvghj 57 1 A a DT cord-298183-cisrvghj 57 2 sequence sequence NN cord-298183-cisrvghj 57 3 - - HYPH cord-298183-cisrvghj 57 4 based base VBN cord-298183-cisrvghj 57 5 approach approach NN cord-298183-cisrvghj 57 6 to to IN cord-298183-cisrvghj 57 7 novel novel JJ cord-298183-cisrvghj 57 8 pathogen pathogen NN cord-298183-cisrvghj 57 9 discovery discovery NN cord-298183-cisrvghj 57 10 has have VBZ cord-298183-cisrvghj 57 11 several several JJ cord-298183-cisrvghj 57 12 advantages advantage NNS cord-298183-cisrvghj 57 13 . . . cord-298183-cisrvghj 58 1 All all DT cord-298183-cisrvghj 58 2 infectious infectious JJ cord-298183-cisrvghj 58 3 agents agent NNS cord-298183-cisrvghj 58 4 should should MD cord-298183-cisrvghj 58 5 be be VB cord-298183-cisrvghj 58 6 detectable detectable JJ cord-298183-cisrvghj 58 7 because because IN cord-298183-cisrvghj 58 8 they -PRON- PRP cord-298183-cisrvghj 58 9 contain contain VBP cord-298183-cisrvghj 58 10 nucleic nucleic JJ cord-298183-cisrvghj 58 11 acids acid NNS cord-298183-cisrvghj 58 12 ( ( -LRB- cord-298183-cisrvghj 58 13 excluding exclude VBG cord-298183-cisrvghj 58 14 prions prion NNS cord-298183-cisrvghj 58 15 ) ) -RRB- cord-298183-cisrvghj 58 16 , , , cord-298183-cisrvghj 58 17 and and CC cord-298183-cisrvghj 58 18 because because IN cord-298183-cisrvghj 58 19 each each DT cord-298183-cisrvghj 58 20 contains contain VBZ cord-298183-cisrvghj 58 21 a a DT cord-298183-cisrvghj 58 22 unique unique JJ cord-298183-cisrvghj 58 23 complement complement NN cord-298183-cisrvghj 58 24 of of IN cord-298183-cisrvghj 58 25 nucleic nucleic JJ cord-298183-cisrvghj 58 26 acid acid NN cord-298183-cisrvghj 58 27 , , , cord-298183-cisrvghj 58 28 different different JJ cord-298183-cisrvghj 58 29 microbes microbe NNS cord-298183-cisrvghj 58 30 should should MD cord-298183-cisrvghj 58 31 be be VB cord-298183-cisrvghj 58 32 distinguishable distinguishable JJ cord-298183-cisrvghj 58 33 . . . cord-298183-cisrvghj 59 1 Nucleic nucleic JJ cord-298183-cisrvghj 59 2 acid acid NN cord-298183-cisrvghj 59 3 amplification amplification NN cord-298183-cisrvghj 59 4 and and CC cord-298183-cisrvghj 59 5 probe probe NN cord-298183-cisrvghj 59 6 - - HYPH cord-298183-cisrvghj 59 7 based base VBN cord-298183-cisrvghj 59 8 signal signal NN cord-298183-cisrvghj 59 9 amplification amplification NN cord-298183-cisrvghj 59 10 methods method NNS cord-298183-cisrvghj 59 11 allow allow VBP cord-298183-cisrvghj 59 12 detection detection NN cord-298183-cisrvghj 59 13 of of IN cord-298183-cisrvghj 59 14 microbial microbial JJ cord-298183-cisrvghj 59 15 nucleic nucleic JJ cord-298183-cisrvghj 59 16 acid acid NN cord-298183-cisrvghj 59 17 sequences sequence NNS cord-298183-cisrvghj 59 18 down down RP cord-298183-cisrvghj 59 19 to to IN cord-298183-cisrvghj 59 20 the the DT cord-298183-cisrvghj 59 21 single single JJ cord-298183-cisrvghj 59 22 - - HYPH cord-298183-cisrvghj 59 23 copy copy NN cord-298183-cisrvghj 59 24 level level NN cord-298183-cisrvghj 59 25 , , , cord-298183-cisrvghj 59 26 yielding yield VBG cord-298183-cisrvghj 59 27 impressive impressive JJ cord-298183-cisrvghj 59 28 assay assay NN cord-298183-cisrvghj 59 29 sensitivities sensitivity NNS cord-298183-cisrvghj 59 30 . . . cord-298183-cisrvghj 60 1 Several several JJ cord-298183-cisrvghj 60 2 sequence sequence NN cord-298183-cisrvghj 60 3 - - HYPH cord-298183-cisrvghj 60 4 based base VBN cord-298183-cisrvghj 60 5 approaches approach NNS cord-298183-cisrvghj 60 6 to to TO cord-298183-cisrvghj 60 7 pathogen pathogen VB cord-298183-cisrvghj 60 8 discovery discovery NN cord-298183-cisrvghj 60 9 have have VBP cord-298183-cisrvghj 60 10 yielded yield VBN cord-298183-cisrvghj 60 11 novel novel JJ cord-298183-cisrvghj 60 12 microbes microbe NNS cord-298183-cisrvghj 60 13 that that WDT cord-298183-cisrvghj 60 14 cause cause VBP cord-298183-cisrvghj 60 15 human human JJ cord-298183-cisrvghj 60 16 disease disease NN cord-298183-cisrvghj 60 17 . . . cord-298183-cisrvghj 61 1 Consensus Consensus NNP cord-298183-cisrvghj 61 2 PCR PCR NNP cord-298183-cisrvghj 61 3 has have VBZ cord-298183-cisrvghj 61 4 been be VBN cord-298183-cisrvghj 61 5 used use VBN cord-298183-cisrvghj 61 6 to to TO cord-298183-cisrvghj 61 7 identify identify VB cord-298183-cisrvghj 61 8 the the DT cord-298183-cisrvghj 61 9 bacterial bacterial JJ cord-298183-cisrvghj 61 10 cause cause NN cord-298183-cisrvghj 61 11 of of IN cord-298183-cisrvghj 61 12 Whipple Whipple NNP cord-298183-cisrvghj 61 13 's 's POS cord-298183-cisrvghj 61 14 disease disease NN cord-298183-cisrvghj 61 15 ( ( -LRB- cord-298183-cisrvghj 61 16 Tropheryma Tropheryma NNP cord-298183-cisrvghj 61 17 whipplei whipplei NNP cord-298183-cisrvghj 61 18 ) ) -RRB- cord-298183-cisrvghj 62 1 2 2 LS cord-298183-cisrvghj 62 2 and and CC cord-298183-cisrvghj 62 3 the the DT cord-298183-cisrvghj 62 4 viral viral JJ cord-298183-cisrvghj 62 5 cause cause NN cord-298183-cisrvghj 62 6 of of IN cord-298183-cisrvghj 62 7 hantavirus hantavirus NN cord-298183-cisrvghj 62 8 pulmonary pulmonary JJ cord-298183-cisrvghj 62 9 syndrome syndrome NN cord-298183-cisrvghj 63 1 ( ( -LRB- cord-298183-cisrvghj 63 2 Sin sin NN cord-298183-cisrvghj 63 3 Nombre Nombre NNP cord-298183-cisrvghj 63 4 virus virus NN cord-298183-cisrvghj 63 5 and and CC cord-298183-cisrvghj 63 6 others other NNS cord-298183-cisrvghj 63 7 ) ) -RRB- cord-298183-cisrvghj 63 8 . . . cord-298183-cisrvghj 64 1 3 3 LS cord-298183-cisrvghj 64 2 Hepatitis Hepatitis NNP cord-298183-cisrvghj 64 3 C C NNP cord-298183-cisrvghj 64 4 virus virus NN cord-298183-cisrvghj 64 5 was be VBD cord-298183-cisrvghj 64 6 identified identify VBN cord-298183-cisrvghj 64 7 by by IN cord-298183-cisrvghj 64 8 screening screen VBG cord-298183-cisrvghj 64 9 expression expression NN cord-298183-cisrvghj 64 10 libraries library NNS cord-298183-cisrvghj 64 11 of of IN cord-298183-cisrvghj 64 12 cDNA cDNA NNP cord-298183-cisrvghj 64 13 for for IN cord-298183-cisrvghj 64 14 antigen antigen NNP cord-298183-cisrvghj 64 15 that that WDT cord-298183-cisrvghj 64 16 reacted react VBD cord-298183-cisrvghj 64 17 with with IN cord-298183-cisrvghj 64 18 immune immune JJ cord-298183-cisrvghj 64 19 serum serum NN cord-298183-cisrvghj 64 20 from from IN cord-298183-cisrvghj 64 21 patients patient NNS cord-298183-cisrvghj 64 22 . . . cord-298183-cisrvghj 65 1 4 4 LS cord-298183-cisrvghj 65 2 Human human JJ cord-298183-cisrvghj 65 3 herpesvirus herpesvirus NN cord-298183-cisrvghj 65 4 8 8 CD cord-298183-cisrvghj 65 5 ( ( -LRB- cord-298183-cisrvghj 65 6 the the DT cord-298183-cisrvghj 65 7 cause cause NN cord-298183-cisrvghj 65 8 of of IN cord-298183-cisrvghj 65 9 Kaposi Kaposi NNP cord-298183-cisrvghj 65 10 's 's POS cord-298183-cisrvghj 65 11 sarcoma sarcoma NN cord-298183-cisrvghj 65 12 ) ) -RRB- cord-298183-cisrvghj 65 13 was be VBD cord-298183-cisrvghj 65 14 identified identify VBN cord-298183-cisrvghj 65 15 using use VBG cord-298183-cisrvghj 65 16 representational representational JJ cord-298183-cisrvghj 65 17 difference difference NN cord-298183-cisrvghj 65 18 analysis analysis NN cord-298183-cisrvghj 65 19 . . . cord-298183-cisrvghj 66 1 5 5 LS cord-298183-cisrvghj 67 1 In in IN cord-298183-cisrvghj 67 2 this this DT cord-298183-cisrvghj 67 3 method method NN cord-298183-cisrvghj 67 4 , , , cord-298183-cisrvghj 67 5 a a DT cord-298183-cisrvghj 67 6 unique unique JJ cord-298183-cisrvghj 67 7 microbial microbial JJ cord-298183-cisrvghj 67 8 DNA dna NN cord-298183-cisrvghj 67 9 fragment fragment NN cord-298183-cisrvghj 67 10 was be VBD cord-298183-cisrvghj 67 11 enriched enrich VBN cord-298183-cisrvghj 67 12 in in IN cord-298183-cisrvghj 67 13 a a DT cord-298183-cisrvghj 67 14 tissue tissue NN cord-298183-cisrvghj 67 15 sample sample NN cord-298183-cisrvghj 67 16 using use VBG cord-298183-cisrvghj 67 17 subtractive subtractive JJ cord-298183-cisrvghj 67 18 hybridization hybridization NN cord-298183-cisrvghj 67 19 and and CC cord-298183-cisrvghj 67 20 PCR pcr NN cord-298183-cisrvghj 67 21 - - HYPH cord-298183-cisrvghj 67 22 based base VBN cord-298183-cisrvghj 67 23 amplification amplification NN cord-298183-cisrvghj 67 24 . . . cord-298183-cisrvghj 68 1 The the DT cord-298183-cisrvghj 68 2 novel novel JJ cord-298183-cisrvghj 68 3 coronavirus coronavirus NN cord-298183-cisrvghj 68 4 associated associate VBN cord-298183-cisrvghj 68 5 with with IN cord-298183-cisrvghj 68 6 severe severe JJ cord-298183-cisrvghj 68 7 acute acute JJ cord-298183-cisrvghj 68 8 respiratory respiratory JJ cord-298183-cisrvghj 68 9 syndrome syndrome NN cord-298183-cisrvghj 68 10 ( ( -LRB- cord-298183-cisrvghj 68 11 SARS SARS NNP cord-298183-cisrvghj 68 12 ) ) -RRB- cord-298183-cisrvghj 68 13 was be VBD cord-298183-cisrvghj 68 14 detected detect VBN cord-298183-cisrvghj 68 15 using use VBG cord-298183-cisrvghj 68 16 a a DT cord-298183-cisrvghj 68 17 pan pan JJ cord-298183-cisrvghj 68 18 - - JJ cord-298183-cisrvghj 68 19 viral viral JJ cord-298183-cisrvghj 68 20 DNA dna NN cord-298183-cisrvghj 68 21 microarray microarray NN cord-298183-cisrvghj 68 22 . . . cord-298183-cisrvghj 69 1 6 6 CD cord-298183-cisrvghj 70 1 An an DT cord-298183-cisrvghj 70 2 unidentified unidentified JJ cord-298183-cisrvghj 70 3 virus virus NN cord-298183-cisrvghj 70 4 was be VBD cord-298183-cisrvghj 70 5 cultivated cultivate VBN cord-298183-cisrvghj 70 6 from from IN cord-298183-cisrvghj 70 7 a a DT cord-298183-cisrvghj 70 8 patient patient NN cord-298183-cisrvghj 70 9 with with IN cord-298183-cisrvghj 70 10 SARS SARS NNP cord-298183-cisrvghj 70 11 using use VBG cord-298183-cisrvghj 70 12 Vero Vero NNP cord-298183-cisrvghj 70 13 cells cell NNS cord-298183-cisrvghj 70 14 , , , cord-298183-cisrvghj 70 15 the the DT cord-298183-cisrvghj 70 16 RNA RNA NNP cord-298183-cisrvghj 70 17 from from IN cord-298183-cisrvghj 70 18 this this DT cord-298183-cisrvghj 70 19 culture culture NN cord-298183-cisrvghj 70 20 was be VBD cord-298183-cisrvghj 70 21 reverse reverse RB cord-298183-cisrvghj 70 22 transcribed transcribe VBN cord-298183-cisrvghj 70 23 and and CC cord-298183-cisrvghj 70 24 amplified amplify VBN cord-298183-cisrvghj 70 25 using use VBG cord-298183-cisrvghj 70 26 PCR PCR NNP cord-298183-cisrvghj 70 27 , , , cord-298183-cisrvghj 70 28 and and CC cord-298183-cisrvghj 70 29 the the DT cord-298183-cisrvghj 70 30 labelled label VBN cord-298183-cisrvghj 70 31 cDNA cdna NN cord-298183-cisrvghj 70 32 was be VBD cord-298183-cisrvghj 70 33 hybridized hybridize VBN cord-298183-cisrvghj 70 34 to to IN cord-298183-cisrvghj 70 35 a a DT cord-298183-cisrvghj 70 36 microarray microarray NN cord-298183-cisrvghj 70 37 containing contain VBG cord-298183-cisrvghj 70 38 oligomers oligomer NNS cord-298183-cisrvghj 70 39 complementary complementary JJ cord-298183-cisrvghj 70 40 to to IN cord-298183-cisrvghj 70 41 numerous numerous JJ cord-298183-cisrvghj 70 42 known know VBN cord-298183-cisrvghj 70 43 viruses virus NNS cord-298183-cisrvghj 70 44 . . . cord-298183-cisrvghj 71 1 Hybridization hybridization NN cord-298183-cisrvghj 71 2 of of IN cord-298183-cisrvghj 71 3 the the DT cord-298183-cisrvghj 71 4 cDNA cdna NN cord-298183-cisrvghj 71 5 to to IN cord-298183-cisrvghj 71 6 known know VBN cord-298183-cisrvghj 71 7 coronavirus coronavirus NN cord-298183-cisrvghj 71 8 sequences sequence NNS cord-298183-cisrvghj 71 9 suggested suggest VBD cord-298183-cisrvghj 71 10 that that IN cord-298183-cisrvghj 71 11 the the DT cord-298183-cisrvghj 71 12 viral viral JJ cord-298183-cisrvghj 71 13 isolate isolate NN cord-298183-cisrvghj 71 14 was be VBD cord-298183-cisrvghj 71 15 a a DT cord-298183-cisrvghj 71 16 member member NN cord-298183-cisrvghj 71 17 of of IN cord-298183-cisrvghj 71 18 the the DT cord-298183-cisrvghj 71 19 coronavirus coronavirus NN cord-298183-cisrvghj 71 20 family family NN cord-298183-cisrvghj 71 21 . . . cord-298183-cisrvghj 72 1 The the DT cord-298183-cisrvghj 72 2 viral viral JJ cord-298183-cisrvghj 72 3 genome genome NN cord-298183-cisrvghj 72 4 revealed reveal VBD cord-298183-cisrvghj 72 5 that that IN cord-298183-cisrvghj 72 6 it -PRON- PRP cord-298183-cisrvghj 72 7 was be VBD cord-298183-cisrvghj 72 8 a a DT cord-298183-cisrvghj 72 9 newly newly RB cord-298183-cisrvghj 72 10 characterized characterize VBN cord-298183-cisrvghj 72 11 coronavirus coronavirus NN cord-298183-cisrvghj 72 12 . . . cord-298183-cisrvghj 73 1 Future future JJ cord-298183-cisrvghj 73 2 attempts attempt VBZ cord-298183-cisrvghj 73 3 to to TO cord-298183-cisrvghj 73 4 identify identify VB cord-298183-cisrvghj 73 5 novel novel JJ cord-298183-cisrvghj 73 6 microbes microbe NNS cord-298183-cisrvghj 73 7 associated associate VBN cord-298183-cisrvghj 73 8 with with IN cord-298183-cisrvghj 73 9 human human JJ cord-298183-cisrvghj 73 10 disease disease NN cord-298183-cisrvghj 73 11 may may MD cord-298183-cisrvghj 73 12 use use VB cord-298183-cisrvghj 73 13 other other JJ cord-298183-cisrvghj 73 14 sequence sequence NN cord-298183-cisrvghj 73 15 - - HYPH cord-298183-cisrvghj 73 16 based base VBN cord-298183-cisrvghj 73 17 approaches approach NNS cord-298183-cisrvghj 73 18 . . . cord-298183-cisrvghj 74 1 High high JJ cord-298183-cisrvghj 74 2 - - HYPH cord-298183-cisrvghj 74 3 throughput throughput NN cord-298183-cisrvghj 74 4 sequencing sequencing NN cord-298183-cisrvghj 74 5 may may MD cord-298183-cisrvghj 74 6 allow allow VB cord-298183-cisrvghj 74 7 identification identification NN cord-298183-cisrvghj 74 8 of of IN cord-298183-cisrvghj 74 9 unique unique JJ cord-298183-cisrvghj 74 10 microbial microbial JJ cord-298183-cisrvghj 74 11 nucleic nucleic JJ cord-298183-cisrvghj 74 12 acid acid NN cord-298183-cisrvghj 74 13 sequences sequence NNS cord-298183-cisrvghj 74 14 in in IN cord-298183-cisrvghj 74 15 a a DT cord-298183-cisrvghj 74 16 background background NN cord-298183-cisrvghj 74 17 of of IN cord-298183-cisrvghj 74 18 host host NN cord-298183-cisrvghj 74 19 DNA dna NN cord-298183-cisrvghj 74 20 . . . cord-298183-cisrvghj 75 1 The the DT cord-298183-cisrvghj 75 2 complete complete JJ cord-298183-cisrvghj 75 3 sequencing sequencing NN cord-298183-cisrvghj 75 4 of of IN cord-298183-cisrvghj 75 5 the the DT cord-298183-cisrvghj 75 6 human human JJ cord-298183-cisrvghj 75 7 genome genome NN cord-298183-cisrvghj 75 8 and and CC cord-298183-cisrvghj 75 9 multiple multiple JJ cord-298183-cisrvghj 75 10 microbial microbial JJ cord-298183-cisrvghj 75 11 genomes genome NNS cord-298183-cisrvghj 75 12 make make VBP cord-298183-cisrvghj 75 13 this this DT cord-298183-cisrvghj 75 14 approach approach NN cord-298183-cisrvghj 75 15 more more RBR cord-298183-cisrvghj 75 16 feasible feasible JJ cord-298183-cisrvghj 75 17 . . . cord-298183-cisrvghj 76 1 DNA dna NN cord-298183-cisrvghj 76 2 microarrays microarray NNS cord-298183-cisrvghj 76 3 are be VBP cord-298183-cisrvghj 76 4 also also RB cord-298183-cisrvghj 76 5 likely likely JJ cord-298183-cisrvghj 76 6 to to TO cord-298183-cisrvghj 76 7 be be VB cord-298183-cisrvghj 76 8 used use VBN cord-298183-cisrvghj 76 9 in in IN cord-298183-cisrvghj 76 10 the the DT cord-298183-cisrvghj 76 11 search search NN cord-298183-cisrvghj 76 12 for for IN cord-298183-cisrvghj 76 13 novel novel JJ cord-298183-cisrvghj 76 14 pathogens pathogen NNS cord-298183-cisrvghj 76 15 . . . cord-298183-cisrvghj 77 1 Microarrays microarray NNS cord-298183-cisrvghj 77 2 containing contain VBG cord-298183-cisrvghj 77 3 thousands thousand NNS cord-298183-cisrvghj 77 4 of of IN cord-298183-cisrvghj 77 5 DNA dna NN cord-298183-cisrvghj 77 6 spots spot NNS cord-298183-cisrvghj 77 7 , , , cord-298183-cisrvghj 77 8 representing represent VBG cord-298183-cisrvghj 77 9 a a DT cord-298183-cisrvghj 77 10 diversity diversity NN cord-298183-cisrvghj 77 11 of of IN cord-298183-cisrvghj 77 12 microbial microbial JJ cord-298183-cisrvghj 77 13 and and CC cord-298183-cisrvghj 77 14 viral viral JJ cord-298183-cisrvghj 77 15 genes gene NNS cord-298183-cisrvghj 77 16 , , , cord-298183-cisrvghj 77 17 may may MD cord-298183-cisrvghj 77 18 be be VB cord-298183-cisrvghj 77 19 used use VBN cord-298183-cisrvghj 77 20 to to TO cord-298183-cisrvghj 77 21 detect detect VB cord-298183-cisrvghj 77 22 microbial microbial JJ cord-298183-cisrvghj 77 23 nucleic nucleic JJ cord-298183-cisrvghj 77 24 acids acid NNS cord-298183-cisrvghj 77 25 in in IN cord-298183-cisrvghj 77 26 tissues tissue NNS cord-298183-cisrvghj 77 27 by by IN cord-298183-cisrvghj 77 28 hybridization hybridization NN cord-298183-cisrvghj 77 29 . . . cord-298183-cisrvghj 78 1 Microarrays microarray NNS cord-298183-cisrvghj 78 2 of of IN cord-298183-cisrvghj 78 3 human human JJ cord-298183-cisrvghj 78 4 DNA dna NN cord-298183-cisrvghj 78 5 may may MD cord-298183-cisrvghj 78 6 also also RB cord-298183-cisrvghj 78 7 be be VB cord-298183-cisrvghj 78 8 used use VBN cord-298183-cisrvghj 78 9 to to TO cord-298183-cisrvghj 78 10 monitor monitor VB cord-298183-cisrvghj 78 11 host host NN cord-298183-cisrvghj 78 12 gene gene NN cord-298183-cisrvghj 78 13 expression expression NN cord-298183-cisrvghj 78 14 in in IN cord-298183-cisrvghj 78 15 disease disease NN cord-298183-cisrvghj 78 16 , , , cord-298183-cisrvghj 78 17 as as IN cord-298183-cisrvghj 78 18 a a DT cord-298183-cisrvghj 78 19 means means NN cord-298183-cisrvghj 78 20 of of IN cord-298183-cisrvghj 78 21 looking look VBG cord-298183-cisrvghj 78 22 for for IN cord-298183-cisrvghj 78 23 characteristic characteristic JJ cord-298183-cisrvghj 78 24 host host NN cord-298183-cisrvghj 78 25 response response NN cord-298183-cisrvghj 78 26 profiles profile NNS cord-298183-cisrvghj 78 27 that that WDT cord-298183-cisrvghj 78 28 help help VBP cord-298183-cisrvghj 78 29 identify identify VB cord-298183-cisrvghj 78 30 infectious infectious JJ cord-298183-cisrvghj 78 31 agents agent NNS cord-298183-cisrvghj 78 32 . . . cord-298183-cisrvghj 79 1 Identification identification NN cord-298183-cisrvghj 79 2 of of IN cord-298183-cisrvghj 79 3 novel novel NN cord-298183-cisrvghj 79 4 or or CC cord-298183-cisrvghj 79 5 previously previously RB cord-298183-cisrvghj 79 6 described describe VBN cord-298183-cisrvghj 79 7 infectious infectious JJ cord-298183-cisrvghj 79 8 agents agent NNS cord-298183-cisrvghj 79 9 may may MD cord-298183-cisrvghj 79 10 improve improve VB cord-298183-cisrvghj 79 11 diagnosis diagnosis NN cord-298183-cisrvghj 79 12 , , , cord-298183-cisrvghj 79 13 prevention prevention NN cord-298183-cisrvghj 79 14 and and CC cord-298183-cisrvghj 79 15 treatment treatment NN cord-298183-cisrvghj 79 16 of of IN cord-298183-cisrvghj 79 17 disease disease NN cord-298183-cisrvghj 79 18 . . . cord-298183-cisrvghj 80 1 Because because IN cord-298183-cisrvghj 80 2 of of IN cord-298183-cisrvghj 80 3 the the DT cord-298183-cisrvghj 80 4 continued continue VBN cord-298183-cisrvghj 80 5 evolution evolution NN cord-298183-cisrvghj 80 6 of of IN cord-298183-cisrvghj 80 7 microbes microbe NNS cord-298183-cisrvghj 80 8 and and CC cord-298183-cisrvghj 80 9 of of IN cord-298183-cisrvghj 80 10 humans human NNS cord-298183-cisrvghj 80 11 , , , cord-298183-cisrvghj 80 12 the the DT cord-298183-cisrvghj 80 13 emergence emergence NN cord-298183-cisrvghj 80 14 of of IN cord-298183-cisrvghj 80 15 new new JJ cord-298183-cisrvghj 80 16 pathogens pathogen NNS cord-298183-cisrvghj 80 17 and and CC cord-298183-cisrvghj 80 18 diseases disease NNS cord-298183-cisrvghj 80 19 is be VBZ cord-298183-cisrvghj 80 20 a a DT cord-298183-cisrvghj 80 21 virtual virtual JJ cord-298183-cisrvghj 80 22 certainty certainty NN cord-298183-cisrvghj 80 23 . . . cord-298183-cisrvghj 81 1 The the DT cord-298183-cisrvghj 81 2 agent agent NN cord-298183-cisrvghj 81 3 of of IN cord-298183-cisrvghj 81 4 bacillary bacillary NNP cord-298183-cisrvghj 81 5 angiomatosis angiomatosis NNP cord-298183-cisrvghj 81 6 : : : cord-298183-cisrvghj 81 7 an an DT cord-298183-cisrvghj 81 8 approach approach NN cord-298183-cisrvghj 81 9 to to IN cord-298183-cisrvghj 81 10 the the DT cord-298183-cisrvghj 81 11 identification identification NN cord-298183-cisrvghj 81 12 of of IN cord-298183-cisrvghj 81 13 uncultured uncultured JJ cord-298183-cisrvghj 81 14 pathogens pathogen NNS cord-298183-cisrvghj 81 15 Identification identification NN cord-298183-cisrvghj 81 16 of of IN cord-298183-cisrvghj 81 17 the the DT cord-298183-cisrvghj 81 18 uncultured uncultured JJ cord-298183-cisrvghj 81 19 bacillus bacillus NN cord-298183-cisrvghj 81 20 of of IN cord-298183-cisrvghj 81 21 Whipple Whipple NNP cord-298183-cisrvghj 81 22 's 's POS cord-298183-cisrvghj 81 23 disease disease NN cord-298183-cisrvghj 81 24 Genetic genetic JJ cord-298183-cisrvghj 81 25 identification identification NN cord-298183-cisrvghj 81 26 of of IN cord-298183-cisrvghj 81 27 a a DT cord-298183-cisrvghj 81 28 hantavirus hantavirus NN cord-298183-cisrvghj 81 29 associated associate VBN cord-298183-cisrvghj 81 30 with with IN cord-298183-cisrvghj 81 31 an an DT cord-298183-cisrvghj 81 32 outbreak outbreak NN cord-298183-cisrvghj 81 33 of of IN cord-298183-cisrvghj 81 34 acute acute JJ cord-298183-cisrvghj 81 35 respiratory respiratory JJ cord-298183-cisrvghj 81 36 illness illness NN cord-298183-cisrvghj 81 37 Isolation isolation NN cord-298183-cisrvghj 81 38 of of IN cord-298183-cisrvghj 81 39 a a DT cord-298183-cisrvghj 81 40 cDNA cdna NN cord-298183-cisrvghj 81 41 clone clone NN cord-298183-cisrvghj 81 42 derived derive VBN cord-298183-cisrvghj 81 43 from from IN cord-298183-cisrvghj 81 44 a a DT cord-298183-cisrvghj 81 45 blood blood NN cord-298183-cisrvghj 81 46 - - HYPH cord-298183-cisrvghj 81 47 borne bear VBN cord-298183-cisrvghj 81 48 non non JJ cord-298183-cisrvghj 81 49 - - JJ cord-298183-cisrvghj 81 50 A a JJ cord-298183-cisrvghj 81 51 , , , cord-298183-cisrvghj 81 52 non non JJ cord-298183-cisrvghj 81 53 - - JJ cord-298183-cisrvghj 81 54 B b JJ cord-298183-cisrvghj 81 55 viral viral JJ cord-298183-cisrvghj 81 56 hepatitis hepatitis NN cord-298183-cisrvghj 81 57 genome genome NN cord-298183-cisrvghj 81 58 Identification identification NN cord-298183-cisrvghj 81 59 of of IN cord-298183-cisrvghj 81 60 herpesvirus herpesvirus NN cord-298183-cisrvghj 81 61 - - HYPH cord-298183-cisrvghj 81 62 like like JJ cord-298183-cisrvghj 81 63 DNA dna NN cord-298183-cisrvghj 81 64 sequences sequence NNS cord-298183-cisrvghj 81 65 in in IN cord-298183-cisrvghj 81 66 AIDS AIDS NNP cord-298183-cisrvghj 81 67 - - HYPH cord-298183-cisrvghj 81 68 associated associate VBN cord-298183-cisrvghj 81 69 Kaposi Kaposi NNP cord-298183-cisrvghj 81 70 's 's POS cord-298183-cisrvghj 81 71 sarcoma sarcoma NN cord-298183-cisrvghj 81 72 Viral viral JJ cord-298183-cisrvghj 81 73 discovery discovery NN cord-298183-cisrvghj 81 74 and and CC cord-298183-cisrvghj 81 75 sequence sequence NN cord-298183-cisrvghj 81 76 recovery recovery NN cord-298183-cisrvghj 81 77 using use VBG cord-298183-cisrvghj 81 78 DNA dna NN cord-298183-cisrvghj 81 79 microarrays microarray NNS cord-298183-cisrvghj 81 80 Stereotyped stereotype VBN cord-298183-cisrvghj 81 81 and and CC cord-298183-cisrvghj 81 82 specific specific JJ cord-298183-cisrvghj 81 83 gene gene NN cord-298183-cisrvghj 81 84 expression expression NN cord-298183-cisrvghj 81 85 programs program NNS cord-298183-cisrvghj 81 86 in in IN cord-298183-cisrvghj 81 87 human human JJ cord-298183-cisrvghj 81 88 innate innate JJ cord-298183-cisrvghj 81 89 immune immune JJ cord-298183-cisrvghj 81 90 responses response NNS cord-298183-cisrvghj 81 91 to to IN cord-298183-cisrvghj 81 92 bacteria bacteria NNS cord-298183-cisrvghj 81 93 Infectious infectious JJ cord-298183-cisrvghj 81 94 agents agent NNS cord-298183-cisrvghj 81 95 and and CC cord-298183-cisrvghj 81 96 the the DT cord-298183-cisrvghj 81 97 etiology etiology NN cord-298183-cisrvghj 81 98 of of IN cord-298183-cisrvghj 81 99 chronic chronic JJ cord-298183-cisrvghj 81 100 idiopathic idiopathic JJ cord-298183-cisrvghj 81 101 diseases disease NNS cord-298183-cisrvghj 81 102 Bacterial bacterial JJ cord-298183-cisrvghj 81 103 diversity diversity NN cord-298183-cisrvghj 81 104 within within IN cord-298183-cisrvghj 81 105 the the DT cord-298183-cisrvghj 81 106 human human JJ cord-298183-cisrvghj 81 107 subgingival subgingival NN cord-298183-cisrvghj 81 108 crevice crevice NNP cord-298183-cisrvghj 82 1 A a DT cord-298183-cisrvghj 82 2 molecular molecular JJ cord-298183-cisrvghj 82 3 view view NN cord-298183-cisrvghj 82 4 of of IN cord-298183-cisrvghj 82 5 microbial microbial JJ cord-298183-cisrvghj 82 6 diversity diversity NN cord-298183-cisrvghj 82 7 and and CC cord-298183-cisrvghj 82 8 the the DT cord-298183-cisrvghj 82 9 biosphere biosphere NN cord-298183-cisrvghj 82 10 Characterization characterization NN cord-298183-cisrvghj 82 11 of of IN cord-298183-cisrvghj 82 12 a a DT cord-298183-cisrvghj 82 13 novel novel JJ cord-298183-cisrvghj 82 14 coronavirus coronavirus NN cord-298183-cisrvghj 82 15 associated associate VBN cord-298183-cisrvghj 82 16 with with IN cord-298183-cisrvghj 82 17 severe severe JJ cord-298183-cisrvghj 82 18 acute acute JJ cord-298183-cisrvghj 82 19 respiratory respiratory JJ cord-298183-cisrvghj 82 20 syndrome syndrome NN