id	sid	tid	token	lemma	pos
cord-297078-pxggjaby	1	1	key	key	NN
cord-297078-pxggjaby	1	2	:	:	:
cord-297078-pxggjaby	2	1	cord-297078-pxggjaby	cord-297078-pxggjaby	NFP
cord-297078-pxggjaby	2	2	authors	author	NNS
cord-297078-pxggjaby	2	3	:	:	:
cord-297078-pxggjaby	2	4	Poole	Poole	NNP
cord-297078-pxggjaby	2	5	,	,	,
cord-297078-pxggjaby	2	6	Anthony	Anthony	NNP
cord-297078-pxggjaby	2	7	M.	M.	NNP
cord-297078-pxggjaby	2	8	;	;	:
cord-297078-pxggjaby	2	9	Logan	Logan	NNP
cord-297078-pxggjaby	2	10	,	,	,
cord-297078-pxggjaby	2	11	Derek	Derek	NNP
cord-297078-pxggjaby	2	12	T.	T.	NNP
cord-297078-pxggjaby	2	13	title	title	NN
cord-297078-pxggjaby	2	14	:	:	:
cord-297078-pxggjaby	2	15	Modern	modern	JJ
cord-297078-pxggjaby	3	1	mRNA	mRNA	NNP
cord-297078-pxggjaby	3	2	Proofreading	Proofreading	NNP
cord-297078-pxggjaby	3	3	and	and	CC
cord-297078-pxggjaby	3	4	Repair	repair	NN
cord-297078-pxggjaby	3	5	:	:	:
cord-297078-pxggjaby	3	6	Clues	clue	NNS
cord-297078-pxggjaby	3	7	that	that	WDT
cord-297078-pxggjaby	3	8	the	the	DT
cord-297078-pxggjaby	3	9	Last	last	JJ
cord-297078-pxggjaby	3	10	Universal	Universal	NNP
cord-297078-pxggjaby	3	11	Common	Common	NNP
cord-297078-pxggjaby	3	12	Ancestor	Ancestor	NNP
cord-297078-pxggjaby	3	13	Possessed	possess	VBD
cord-297078-pxggjaby	3	14	an	an	DT
cord-297078-pxggjaby	3	15	RNA	RNA	NNP
cord-297078-pxggjaby	3	16	Genome	Genome	NNP
cord-297078-pxggjaby	3	17	?	?	.
cord-297078-pxggjaby	4	1	date	date	NN
cord-297078-pxggjaby	4	2	:	:	:
cord-297078-pxggjaby	4	3	2005	2005	CD
cord-297078-pxggjaby	4	4	-	-	HYPH
cord-297078-pxggjaby	4	5	03	03	CD
cord-297078-pxggjaby	4	6	-	-	HYPH
cord-297078-pxggjaby	4	7	16	16	CD
cord-297078-pxggjaby	4	8	journal	journal	NN
cord-297078-pxggjaby	4	9	:	:	:
cord-297078-pxggjaby	5	1	Mol	Mol	NNP
cord-297078-pxggjaby	5	2	Biol	Biol	NNP
cord-297078-pxggjaby	5	3	Evol	Evol	NNP
cord-297078-pxggjaby	5	4	DOI	DOI	NNP
cord-297078-pxggjaby	5	5	:	:	:
cord-297078-pxggjaby	5	6	10.1093	10.1093	CD
cord-297078-pxggjaby	5	7	/	/	SYM
cord-297078-pxggjaby	5	8	molbev	molbev	NNP
cord-297078-pxggjaby	5	9	/	/	SYM
cord-297078-pxggjaby	5	10	msi132	msi132	NNP
cord-297078-pxggjaby	5	11	sha	sha	NNP
cord-297078-pxggjaby	5	12	:	:	:
cord-297078-pxggjaby	5	13	c0925ae90f68d553dbafe5af07f7aa24b31faf52	c0925ae90f68d553dbafe5af07f7aa24b31faf52	NNP
cord-297078-pxggjaby	5	14	doc_id	doc_id	CD
cord-297078-pxggjaby	5	15	:	:	:
cord-297078-pxggjaby	5	16	297078	297078	CD
cord-297078-pxggjaby	5	17	cord_uid	cord_uid	NNS
cord-297078-pxggjaby	5	18	:	:	:
cord-297078-pxggjaby	6	1	pxggjaby	pxggjaby	NNP
cord-297078-pxggjaby	6	2	RNA	RNA	NNP
cord-297078-pxggjaby	6	3	repair	repair	NN
cord-297078-pxggjaby	6	4	has	have	VBZ
cord-297078-pxggjaby	6	5	now	now	RB
cord-297078-pxggjaby	6	6	been	be	VBN
cord-297078-pxggjaby	6	7	demonstrated	demonstrate	VBN
cord-297078-pxggjaby	6	8	to	to	TO
cord-297078-pxggjaby	6	9	be	be	VB
cord-297078-pxggjaby	6	10	a	a	DT
cord-297078-pxggjaby	6	11	genuine	genuine	JJ
cord-297078-pxggjaby	6	12	biological	biological	JJ
cord-297078-pxggjaby	6	13	process	process	NN
cord-297078-pxggjaby	6	14	and	and	CC
cord-297078-pxggjaby	6	15	appears	appear	VBZ
cord-297078-pxggjaby	6	16	to	to	TO
cord-297078-pxggjaby	6	17	be	be	VB
cord-297078-pxggjaby	6	18	present	present	JJ
cord-297078-pxggjaby	6	19	in	in	IN
cord-297078-pxggjaby	6	20	all	all	DT
cord-297078-pxggjaby	6	21	three	three	CD
cord-297078-pxggjaby	6	22	domains	domain	NNS
cord-297078-pxggjaby	6	23	of	of	IN
cord-297078-pxggjaby	6	24	life	life	NN
cord-297078-pxggjaby	6	25	.	.	.
cord-297078-pxggjaby	7	1	In	in	IN
cord-297078-pxggjaby	7	2	this	this	DT
cord-297078-pxggjaby	7	3	article	article	NN
cord-297078-pxggjaby	7	4	,	,	,
cord-297078-pxggjaby	7	5	we	-PRON-	PRP
cord-297078-pxggjaby	7	6	consider	consider	VBP
cord-297078-pxggjaby	7	7	what	what	WP
cord-297078-pxggjaby	7	8	this	this	DT
cord-297078-pxggjaby	7	9	might	may	MD
cord-297078-pxggjaby	7	10	mean	mean	VB
cord-297078-pxggjaby	7	11	for	for	IN
cord-297078-pxggjaby	7	12	the	the	DT
cord-297078-pxggjaby	7	13	transition	transition	NN
cord-297078-pxggjaby	7	14	from	from	IN
cord-297078-pxggjaby	7	15	an	an	DT
cord-297078-pxggjaby	7	16	early	early	JJ
cord-297078-pxggjaby	7	17	RNA	rna	NN
cord-297078-pxggjaby	7	18	-	-	HYPH
cord-297078-pxggjaby	7	19	dominated	dominate	VBN
cord-297078-pxggjaby	7	20	world	world	NN
cord-297078-pxggjaby	7	21	to	to	IN
cord-297078-pxggjaby	7	22	modern	modern	JJ
cord-297078-pxggjaby	7	23	cells	cell	NNS
cord-297078-pxggjaby	7	24	possessing	possess	VBG
cord-297078-pxggjaby	7	25	genetically	genetically	RB
cord-297078-pxggjaby	7	26	encoded	encode	VBN
cord-297078-pxggjaby	7	27	proteins	protein	NNS
cord-297078-pxggjaby	7	28	and	and	CC
cord-297078-pxggjaby	7	29	DNA	dna	NN
cord-297078-pxggjaby	7	30	.	.	.
cord-297078-pxggjaby	8	1	There	there	EX
cord-297078-pxggjaby	8	2	are	be	VBP
cord-297078-pxggjaby	8	3	significant	significant	JJ
cord-297078-pxggjaby	8	4	gaps	gap	NNS
cord-297078-pxggjaby	8	5	in	in	IN
cord-297078-pxggjaby	8	6	our	-PRON-	PRP$
cord-297078-pxggjaby	8	7	understanding	understanding	NN
cord-297078-pxggjaby	8	8	of	of	IN
cord-297078-pxggjaby	8	9	how	how	WRB
cord-297078-pxggjaby	8	10	the	the	DT
cord-297078-pxggjaby	8	11	modern	modern	JJ
cord-297078-pxggjaby	8	12	protein	protein	NN
cord-297078-pxggjaby	8	13	-	-	HYPH
cord-297078-pxggjaby	8	14	DNA	dna	NN
cord-297078-pxggjaby	8	15	world	world	NN
cord-297078-pxggjaby	8	16	could	could	MD
cord-297078-pxggjaby	8	17	have	have	VB
cord-297078-pxggjaby	8	18	evolved	evolve	VBN
cord-297078-pxggjaby	8	19	from	from	IN
cord-297078-pxggjaby	8	20	a	a	DT
cord-297078-pxggjaby	8	21	simpler	simple	JJR
cord-297078-pxggjaby	8	22	system	system	NN
cord-297078-pxggjaby	8	23	,	,	,
cord-297078-pxggjaby	8	24	and	and	CC
cord-297078-pxggjaby	8	25	it	-PRON-	PRP
cord-297078-pxggjaby	8	26	is	be	VBZ
cord-297078-pxggjaby	8	27	currently	currently	RB
cord-297078-pxggjaby	8	28	uncertain	uncertain	JJ
cord-297078-pxggjaby	8	29	whether	whether	IN
cord-297078-pxggjaby	8	30	DNA	dna	NN
cord-297078-pxggjaby	8	31	genomes	genome	NNS
cord-297078-pxggjaby	8	32	evolved	evolve	VBN
cord-297078-pxggjaby	8	33	once	once	RB
cord-297078-pxggjaby	8	34	or	or	CC
cord-297078-pxggjaby	8	35	twice	twice	RB
cord-297078-pxggjaby	8	36	.	.	.
cord-297078-pxggjaby	9	1	Against	against	IN
cord-297078-pxggjaby	9	2	this	this	DT
cord-297078-pxggjaby	9	3	backdrop	backdrop	NN
cord-297078-pxggjaby	9	4	,	,	,
cord-297078-pxggjaby	9	5	the	the	DT
cord-297078-pxggjaby	9	6	discovery	discovery	NN
cord-297078-pxggjaby	9	7	of	of	IN
cord-297078-pxggjaby	9	8	RNA	RNA	NNP
cord-297078-pxggjaby	9	9	repair	repair	NN
cord-297078-pxggjaby	9	10	in	in	IN
cord-297078-pxggjaby	9	11	modern	modern	JJ
cord-297078-pxggjaby	9	12	cells	cell	NNS
cord-297078-pxggjaby	9	13	is	be	VBZ
cord-297078-pxggjaby	9	14	timely	timely	JJ
cord-297078-pxggjaby	9	15	food	food	NN
cord-297078-pxggjaby	9	16	for	for	IN
cord-297078-pxggjaby	9	17	thought	thought	NN
cord-297078-pxggjaby	9	18	and	and	CC
cord-297078-pxggjaby	9	19	brings	bring	VBZ
cord-297078-pxggjaby	9	20	us	-PRON-	PRP
cord-297078-pxggjaby	9	21	conceptually	conceptually	RB
cord-297078-pxggjaby	9	22	one	one	CD
cord-297078-pxggjaby	9	23	step	step	NN
cord-297078-pxggjaby	9	24	closer	close	RBR
cord-297078-pxggjaby	9	25	to	to	IN
cord-297078-pxggjaby	9	26	understanding	understand	VBG
cord-297078-pxggjaby	9	27	how	how	WRB
cord-297078-pxggjaby	9	28	RNA	RNA	NNP
cord-297078-pxggjaby	9	29	genomes	genome	NNS
cord-297078-pxggjaby	9	30	were	be	VBD
cord-297078-pxggjaby	9	31	replaced	replace	VBN
cord-297078-pxggjaby	9	32	by	by	IN
cord-297078-pxggjaby	9	33	DNA	dna	NN
cord-297078-pxggjaby	9	34	genomes	genome	NNS
cord-297078-pxggjaby	9	35	.	.	.
cord-297078-pxggjaby	10	1	We	-PRON-	PRP
cord-297078-pxggjaby	10	2	have	have	VBP
cord-297078-pxggjaby	10	3	examined	examine	VBN
cord-297078-pxggjaby	10	4	the	the	DT
cord-297078-pxggjaby	10	5	available	available	JJ
cord-297078-pxggjaby	10	6	literature	literature	NN
cord-297078-pxggjaby	10	7	on	on	IN
cord-297078-pxggjaby	10	8	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	10	9	RNA	RNA	NNP
cord-297078-pxggjaby	10	10	polymerase	polymerase	NN
cord-297078-pxggjaby	10	11	structure	structure	NN
cord-297078-pxggjaby	10	12	and	and	CC
cord-297078-pxggjaby	10	13	function	function	NN
cord-297078-pxggjaby	10	14	and	and	CC
cord-297078-pxggjaby	10	15	conclude	conclude	VBP
cord-297078-pxggjaby	10	16	that	that	IN
cord-297078-pxggjaby	10	17	a	a	DT
cord-297078-pxggjaby	10	18	strong	strong	JJ
cord-297078-pxggjaby	10	19	case	case	NN
cord-297078-pxggjaby	10	20	can	can	MD
cord-297078-pxggjaby	10	21	be	be	VB
cord-297078-pxggjaby	10	22	made	make	VBN
cord-297078-pxggjaby	10	23	that	that	IN
cord-297078-pxggjaby	10	24	the	the	DT
cord-297078-pxggjaby	10	25	Last	last	JJ
cord-297078-pxggjaby	10	26	Universal	Universal	NNP
cord-297078-pxggjaby	10	27	Common	Common	NNP
cord-297078-pxggjaby	10	28	Ancestor	Ancestor	NNP
cord-297078-pxggjaby	10	29	(	(	-LRB-
cord-297078-pxggjaby	10	30	LUCA	LUCA	NNP
cord-297078-pxggjaby	10	31	)	)	-RRB-
cord-297078-pxggjaby	10	32	possessed	possess	VBD
cord-297078-pxggjaby	10	33	a	a	DT
cord-297078-pxggjaby	10	34	repair	repair	NN
cord-297078-pxggjaby	10	35	-	-	HYPH
cord-297078-pxggjaby	10	36	competent	competent	JJ
cord-297078-pxggjaby	10	37	RNA	RNA	NNP
cord-297078-pxggjaby	10	38	polymerase	polymerase	NN
cord-297078-pxggjaby	10	39	,	,	,
cord-297078-pxggjaby	10	40	which	which	WDT
cord-297078-pxggjaby	10	41	would	would	MD
cord-297078-pxggjaby	10	42	have	have	VB
cord-297078-pxggjaby	10	43	been	be	VBN
cord-297078-pxggjaby	10	44	capable	capable	JJ
cord-297078-pxggjaby	10	45	of	of	IN
cord-297078-pxggjaby	10	46	acting	act	VBG
cord-297078-pxggjaby	10	47	on	on	IN
cord-297078-pxggjaby	10	48	an	an	DT
cord-297078-pxggjaby	10	49	RNA	RNA	NNP
cord-297078-pxggjaby	10	50	genome	genome	NN
cord-297078-pxggjaby	10	51	.	.	.
cord-297078-pxggjaby	11	1	However	however	RB
cord-297078-pxggjaby	11	2	,	,	,
cord-297078-pxggjaby	11	3	while	while	IN
cord-297078-pxggjaby	11	4	this	this	DT
cord-297078-pxggjaby	11	5	lends	lend	VBZ
cord-297078-pxggjaby	11	6	credibility	credibility	NN
cord-297078-pxggjaby	11	7	to	to	IN
cord-297078-pxggjaby	11	8	the	the	DT
cord-297078-pxggjaby	11	9	proposal	proposal	NN
cord-297078-pxggjaby	11	10	that	that	IN
cord-297078-pxggjaby	11	11	the	the	DT
cord-297078-pxggjaby	11	12	LUCA	LUCA	NNP
cord-297078-pxggjaby	11	13	had	have	VBD
cord-297078-pxggjaby	11	14	an	an	DT
cord-297078-pxggjaby	11	15	RNA	RNA	NNP
cord-297078-pxggjaby	11	16	genome	genome	NN
cord-297078-pxggjaby	11	17	,	,	,
cord-297078-pxggjaby	11	18	the	the	DT
cord-297078-pxggjaby	11	19	alternative	alternative	NN
cord-297078-pxggjaby	11	20	,	,	,
cord-297078-pxggjaby	11	21	that	that	IN
cord-297078-pxggjaby	11	22	LUCA	LUCA	NNP
cord-297078-pxggjaby	11	23	had	have	VBD
cord-297078-pxggjaby	11	24	a	a	DT
cord-297078-pxggjaby	11	25	DNA	dna	NN
cord-297078-pxggjaby	11	26	genome	genome	NN
cord-297078-pxggjaby	11	27	,	,	,
cord-297078-pxggjaby	11	28	can	can	MD
cord-297078-pxggjaby	11	29	not	not	RB
cord-297078-pxggjaby	11	30	be	be	VB
cord-297078-pxggjaby	11	31	completely	completely	RB
cord-297078-pxggjaby	11	32	ruled	rule	VBN
cord-297078-pxggjaby	11	33	out	out	RP
cord-297078-pxggjaby	11	34	.	.	.
cord-297078-pxggjaby	12	1	The	the	DT
cord-297078-pxggjaby	12	2	term	term	NN
cord-297078-pxggjaby	12	3	'	'	''
cord-297078-pxggjaby	12	4	'	'	''
cord-297078-pxggjaby	12	5	RNA	RNA	NNP
cord-297078-pxggjaby	12	6	world	world	NN
cord-297078-pxggjaby	12	7	'	'	''
cord-297078-pxggjaby	12	8	'	'	''
cord-297078-pxggjaby	13	1	(	(	-LRB-
cord-297078-pxggjaby	13	2	Gilbert	Gilbert	NNP
cord-297078-pxggjaby	13	3	1986	1986	CD
cord-297078-pxggjaby	13	4	)	)	-RRB-
cord-297078-pxggjaby	13	5	gave	give	VBD
cord-297078-pxggjaby	13	6	a	a	DT
cord-297078-pxggjaby	13	7	name	name	NN
cord-297078-pxggjaby	13	8	to	to	IN
cord-297078-pxggjaby	13	9	the	the	DT
cord-297078-pxggjaby	13	10	hypothesis	hypothesis	NN
cord-297078-pxggjaby	13	11	that	that	IN
cord-297078-pxggjaby	13	12	,	,	,
cord-297078-pxggjaby	13	13	before	before	IN
cord-297078-pxggjaby	13	14	proteins	protein	NNS
cord-297078-pxggjaby	13	15	and	and	CC
cord-297078-pxggjaby	13	16	DNA	DNA	NNP
cord-297078-pxggjaby	13	17	,	,	,
cord-297078-pxggjaby	13	18	RNA	RNA	NNP
cord-297078-pxggjaby	13	19	was	be	VBD
cord-297078-pxggjaby	13	20	the	the	DT
cord-297078-pxggjaby	13	21	main	main	JJ
cord-297078-pxggjaby	13	22	biological	biological	JJ
cord-297078-pxggjaby	13	23	catalyst	catalyst	NN
cord-297078-pxggjaby	13	24	and	and	CC
cord-297078-pxggjaby	13	25	genetic	genetic	JJ
cord-297078-pxggjaby	13	26	material	material	NN
cord-297078-pxggjaby	13	27	(	(	-LRB-
cord-297078-pxggjaby	13	28	Woese	Woese	NNP
cord-297078-pxggjaby	13	29	1967	1967	CD
cord-297078-pxggjaby	13	30	;	;	:
cord-297078-pxggjaby	13	31	Crick	Crick	NNP
cord-297078-pxggjaby	13	32	1968	1968	CD
cord-297078-pxggjaby	13	33	;	;	:
cord-297078-pxggjaby	13	34	Orgel	Orgel	NNP
cord-297078-pxggjaby	13	35	1968	1968	CD
cord-297078-pxggjaby	13	36	)	)	-RRB-
cord-297078-pxggjaby	13	37	.	.	.
cord-297078-pxggjaby	14	1	The	the	DT
cord-297078-pxggjaby	14	2	hypothesis	hypothesis	NN
cord-297078-pxggjaby	14	3	was	be	VBD
cord-297078-pxggjaby	14	4	bolstered	bolster	VBN
cord-297078-pxggjaby	14	5	by	by	IN
cord-297078-pxggjaby	14	6	the	the	DT
cord-297078-pxggjaby	14	7	discovery	discovery	NN
cord-297078-pxggjaby	14	8	of	of	IN
cord-297078-pxggjaby	14	9	catalytic	catalytic	JJ
cord-297078-pxggjaby	14	10	RNA	RNA	NNP
cord-297078-pxggjaby	14	11	(	(	-LRB-
cord-297078-pxggjaby	14	12	Kruger	Kruger	NNP
cord-297078-pxggjaby	14	13	et	et	NNP
cord-297078-pxggjaby	14	14	al	al	NNP
cord-297078-pxggjaby	14	15	.	.	NNP
cord-297078-pxggjaby	14	16	1982	1982	CD
cord-297078-pxggjaby	14	17	;	;	:
cord-297078-pxggjaby	14	18	Guerrier	Guerrier	NNP
cord-297078-pxggjaby	14	19	-	-	HYPH
cord-297078-pxggjaby	14	20	Takada	Takada	NNP
cord-297078-pxggjaby	14	21	et	et	FW
cord-297078-pxggjaby	14	22	al	al	NNP
cord-297078-pxggjaby	14	23	.	.	.
cord-297078-pxggjaby	14	24	1983	1983	CD
cord-297078-pxggjaby	14	25	)	)	-RRB-
cord-297078-pxggjaby	14	26	,	,	,
cord-297078-pxggjaby	14	27	building	build	VBG
cord-297078-pxggjaby	14	28	on	on	IN
cord-297078-pxggjaby	14	29	the	the	DT
cord-297078-pxggjaby	14	30	earlier	early	JJR
cord-297078-pxggjaby	14	31	discovery	discovery	NN
cord-297078-pxggjaby	14	32	that	that	WDT
cord-297078-pxggjaby	14	33	RNA	RNA	NNP
cord-297078-pxggjaby	14	34	is	be	VBZ
cord-297078-pxggjaby	14	35	the	the	DT
cord-297078-pxggjaby	14	36	genetic	genetic	JJ
cord-297078-pxggjaby	14	37	material	material	NN
cord-297078-pxggjaby	14	38	in	in	IN
cord-297078-pxggjaby	14	39	some	some	DT
cord-297078-pxggjaby	14	40	viruses	virus	NNS
cord-297078-pxggjaby	14	41	(	(	-LRB-
cord-297078-pxggjaby	14	42	Fraenkel	Fraenkel	NNP
cord-297078-pxggjaby	14	43	-	-	HYPH
cord-297078-pxggjaby	14	44	Conrat	Conrat	NNP
cord-297078-pxggjaby	14	45	1956	1956	CD
cord-297078-pxggjaby	14	46	;	;	:
cord-297078-pxggjaby	14	47	Gierer	Gierer	NNP
cord-297078-pxggjaby	14	48	and	and	CC
cord-297078-pxggjaby	14	49	Schramm	Schramm	NNP
cord-297078-pxggjaby	14	50	1956	1956	CD
cord-297078-pxggjaby	14	51	)	)	-RRB-
cord-297078-pxggjaby	14	52	and	and	CC
cord-297078-pxggjaby	14	53	in	in	IN
cord-297078-pxggjaby	14	54	plant	plant	NN
cord-297078-pxggjaby	14	55	viroids	viroid	NNS
cord-297078-pxggjaby	14	56	(	(	-LRB-
cord-297078-pxggjaby	14	57	Diener	Diener	NNP
cord-297078-pxggjaby	14	58	1971	1971	CD
cord-297078-pxggjaby	14	59	)	)	-RRB-
cord-297078-pxggjaby	14	60	,	,	,
cord-297078-pxggjaby	14	61	the	the	DT
cord-297078-pxggjaby	14	62	latter	latter	JJ
cord-297078-pxggjaby	14	63	possessing	possess	VBG
cord-297078-pxggjaby	14	64	catalytic	catalytic	JJ
cord-297078-pxggjaby	14	65	RNA	RNA	NNP
cord-297078-pxggjaby	14	66	but	but	CC
cord-297078-pxggjaby	14	67	not	not	RB
cord-297078-pxggjaby	14	68	protein	protein	NN
cord-297078-pxggjaby	14	69	(	(	-LRB-
cord-297078-pxggjaby	14	70	Flores	Flores	NNP
cord-297078-pxggjaby	14	71	et	et	NNP
cord-297078-pxggjaby	14	72	al	al	NNP
cord-297078-pxggjaby	14	73	.	.	.
cord-297078-pxggjaby	14	74	2004	2004	CD
cord-297078-pxggjaby	14	75	)	)	-RRB-
cord-297078-pxggjaby	14	76	.	.	.
cord-297078-pxggjaby	15	1	The	the	DT
cord-297078-pxggjaby	15	2	theory	theory	NN
cord-297078-pxggjaby	15	3	has	have	VBZ
cord-297078-pxggjaby	15	4	been	be	VBN
cord-297078-pxggjaby	15	5	extensively	extensively	RB
cord-297078-pxggjaby	15	6	developed	develop	VBN
cord-297078-pxggjaby	15	7	and	and	CC
cord-297078-pxggjaby	15	8	has	have	VBZ
cord-297078-pxggjaby	15	9	gained	gain	VBN
cord-297078-pxggjaby	15	10	much	much	JJ
cord-297078-pxggjaby	15	11	support	support	NN
cord-297078-pxggjaby	15	12	(	(	-LRB-
cord-297078-pxggjaby	15	13	White	White	NNP
cord-297078-pxggjaby	15	14	1976	1976	CD
cord-297078-pxggjaby	15	15	;	;	:
cord-297078-pxggjaby	15	16	Benner	Benner	NNP
cord-297078-pxggjaby	15	17	,	,	,
cord-297078-pxggjaby	15	18	Ellington	Ellington	NNP
cord-297078-pxggjaby	15	19	,	,	,
cord-297078-pxggjaby	15	20	and	and	CC
cord-297078-pxggjaby	15	21	Tauer	Tauer	NNP
cord-297078-pxggjaby	15	22	1989	1989	CD
cord-297078-pxggjaby	15	23	;	;	:
cord-297078-pxggjaby	15	24	Jeffares	Jeffares	NNP
cord-297078-pxggjaby	15	25	,	,	,
cord-297078-pxggjaby	15	26	Poole	Poole	NNP
cord-297078-pxggjaby	15	27	,	,	,
cord-297078-pxggjaby	15	28	and	and	CC
cord-297078-pxggjaby	15	29	Penny	penny	NN
cord-297078-pxggjaby	15	30	1998	1998	CD
cord-297078-pxggjaby	15	31	;	;	:
cord-297078-pxggjaby	15	32	Joyce	Joyce	NNP
cord-297078-pxggjaby	15	33	and	and	CC
cord-297078-pxggjaby	15	34	Orgel	Orgel	NNP
cord-297078-pxggjaby	15	35	1999	1999	CD
cord-297078-pxggjaby	15	36	;	;	:
cord-297078-pxggjaby	15	37	Yarus	Yarus	NNP
cord-297078-pxggjaby	15	38	2002	2002	CD
cord-297078-pxggjaby	15	39	)	)	-RRB-
cord-297078-pxggjaby	15	40	;	;	:
cord-297078-pxggjaby	15	41	nevertheless	nevertheless	RB
cord-297078-pxggjaby	15	42	,	,	,
cord-297078-pxggjaby	15	43	there	there	EX
cord-297078-pxggjaby	15	44	are	be	VBP
cord-297078-pxggjaby	15	45	many	many	JJ
cord-297078-pxggjaby	15	46	unresolved	unresolved	JJ
cord-297078-pxggjaby	15	47	issues	issue	NNS
cord-297078-pxggjaby	15	48	.	.	.
cord-297078-pxggjaby	16	1	One	one	CD
cord-297078-pxggjaby	16	2	such	such	JJ
cord-297078-pxggjaby	16	3	issue	issue	NN
cord-297078-pxggjaby	16	4	,	,	,
cord-297078-pxggjaby	16	5	and	and	CC
cord-297078-pxggjaby	16	6	the	the	DT
cord-297078-pxggjaby	16	7	subject	subject	NN
cord-297078-pxggjaby	16	8	of	of	IN
cord-297078-pxggjaby	16	9	this	this	DT
cord-297078-pxggjaby	16	10	article	article	NN
cord-297078-pxggjaby	16	11	,	,	,
cord-297078-pxggjaby	16	12	is	be	VBZ
cord-297078-pxggjaby	16	13	the	the	DT
cord-297078-pxggjaby	16	14	timing	timing	NN
cord-297078-pxggjaby	16	15	and	and	CC
cord-297078-pxggjaby	16	16	nature	nature	NN
cord-297078-pxggjaby	16	17	of	of	IN
cord-297078-pxggjaby	16	18	the	the	DT
cord-297078-pxggjaby	16	19	evolutionary	evolutionary	JJ
cord-297078-pxggjaby	16	20	transition	transition	NN
cord-297078-pxggjaby	16	21	from	from	IN
cord-297078-pxggjaby	16	22	RNA	RNA	NNP
cord-297078-pxggjaby	16	23	to	to	IN
cord-297078-pxggjaby	16	24	DNA	DNA	NNP
cord-297078-pxggjaby	16	25	.	.	.
cord-297078-pxggjaby	17	1	It	-PRON-	PRP
cord-297078-pxggjaby	17	2	is	be	VBZ
cord-297078-pxggjaby	17	3	widely	widely	RB
cord-297078-pxggjaby	17	4	accepted	accept	VBN
cord-297078-pxggjaby	17	5	that	that	IN
cord-297078-pxggjaby	17	6	protein	protein	NN
cord-297078-pxggjaby	17	7	synthesis	synthesis	NN
cord-297078-pxggjaby	17	8	evolved	evolve	VBD
cord-297078-pxggjaby	17	9	from	from	IN
cord-297078-pxggjaby	17	10	an	an	DT
cord-297078-pxggjaby	17	11	RNA	RNA	NNP
cord-297078-pxggjaby	17	12	world	world	NN
cord-297078-pxggjaby	17	13	Noller	Noller	NNP
cord-297078-pxggjaby	17	14	2004	2004	CD
cord-297078-pxggjaby	17	15	)	)	-RRB-
cord-297078-pxggjaby	17	16	,	,	,
cord-297078-pxggjaby	17	17	major	major	JJ
cord-297078-pxggjaby	17	18	evidence	evidence	NN
cord-297078-pxggjaby	17	19	being	be	VBG
cord-297078-pxggjaby	17	20	the	the	DT
cord-297078-pxggjaby	17	21	central	central	JJ
cord-297078-pxggjaby	17	22	catalytic	catalytic	JJ
cord-297078-pxggjaby	17	23	role	role	NN
cord-297078-pxggjaby	17	24	of	of	IN
cord-297078-pxggjaby	17	25	RNA	RNA	NNP
cord-297078-pxggjaby	17	26	in	in	IN
cord-297078-pxggjaby	17	27	the	the	DT
cord-297078-pxggjaby	17	28	ribosome	ribosome	NN
cord-297078-pxggjaby	17	29	(	(	-LRB-
cord-297078-pxggjaby	17	30	Moore	Moore	NNP
cord-297078-pxggjaby	17	31	and	and	CC
cord-297078-pxggjaby	17	32	Steitz	Steitz	NNP
cord-297078-pxggjaby	17	33	2002	2002	CD
cord-297078-pxggjaby	17	34	)	)	-RRB-
cord-297078-pxggjaby	17	35	.	.	.
cord-297078-pxggjaby	18	1	Thus	thus	RB
cord-297078-pxggjaby	18	2	,	,	,
cord-297078-pxggjaby	18	3	one	one	CD
cord-297078-pxggjaby	18	4	intermediate	intermediate	JJ
cord-297078-pxggjaby	18	5	stage	stage	NN
cord-297078-pxggjaby	18	6	in	in	IN
cord-297078-pxggjaby	18	7	the	the	DT
cord-297078-pxggjaby	18	8	evolution	evolution	NN
cord-297078-pxggjaby	18	9	of	of	IN
cord-297078-pxggjaby	18	10	the	the	DT
cord-297078-pxggjaby	18	11	modern	modern	JJ
cord-297078-pxggjaby	18	12	DNAprotein	DNAprotein	NNP
cord-297078-pxggjaby	18	13	world	world	NN
cord-297078-pxggjaby	18	14	was	be	VBD
cord-297078-pxggjaby	18	15	a	a	DT
cord-297078-pxggjaby	18	16	'	'	``
cord-297078-pxggjaby	18	17	'	'	``
cord-297078-pxggjaby	18	18	ribonucleoprotein	ribonucleoprotein	NN
cord-297078-pxggjaby	18	19	'	'	''
cord-297078-pxggjaby	18	20	'	'	''
cord-297078-pxggjaby	18	21	(	(	-LRB-
cord-297078-pxggjaby	18	22	RNP	RNP	NNP
cord-297078-pxggjaby	18	23	)	)	-RRB-
cord-297078-pxggjaby	18	24	world	world	NN
cord-297078-pxggjaby	18	25	.	.	.
cord-297078-pxggjaby	19	1	Where	where	WRB
cord-297078-pxggjaby	19	2	DNA	DNA	NNP
cord-297078-pxggjaby	19	3	sits	sit	VBZ
cord-297078-pxggjaby	19	4	in	in	IN
cord-297078-pxggjaby	19	5	the	the	DT
cord-297078-pxggjaby	19	6	picture	picture	NN
cord-297078-pxggjaby	19	7	is	be	VBZ
cord-297078-pxggjaby	19	8	less	less	RBR
cord-297078-pxggjaby	19	9	agreed	agree	VBN
cord-297078-pxggjaby	19	10	upon	upon	IN
cord-297078-pxggjaby	19	11	(	(	-LRB-
cord-297078-pxggjaby	19	12	fig	fig	NN
cord-297078-pxggjaby	19	13	.	.	NNP
cord-297078-pxggjaby	19	14	1	1	CD
cord-297078-pxggjaby	19	15	)	)	-RRB-
cord-297078-pxggjaby	19	16	.	.	.
cord-297078-pxggjaby	20	1	At	at	IN
cord-297078-pxggjaby	20	2	one	one	CD
cord-297078-pxggjaby	20	3	end	end	NN
cord-297078-pxggjaby	20	4	of	of	IN
cord-297078-pxggjaby	20	5	the	the	DT
cord-297078-pxggjaby	20	6	spectrum	spectrum	NN
cord-297078-pxggjaby	20	7	is	be	VBZ
cord-297078-pxggjaby	20	8	the	the	DT
cord-297078-pxggjaby	20	9	proposal	proposal	NN
cord-297078-pxggjaby	20	10	that	that	IN
cord-297078-pxggjaby	20	11	DNA	DNA	NNP
cord-297078-pxggjaby	20	12	evolved	evolve	VBN
cord-297078-pxggjaby	20	13	before	before	IN
cord-297078-pxggjaby	20	14	protein	protein	NN
cord-297078-pxggjaby	20	15	(	(	-LRB-
cord-297078-pxggjaby	20	16	Benner	Benner	NNP
cord-297078-pxggjaby	20	17	,	,	,
cord-297078-pxggjaby	20	18	Ellington	Ellington	NNP
cord-297078-pxggjaby	20	19	,	,	,
cord-297078-pxggjaby	20	20	and	and	CC
cord-297078-pxggjaby	20	21	Tauer	Tauer	NNP
cord-297078-pxggjaby	20	22	1989	1989	CD
cord-297078-pxggjaby	20	23	)	)	-RRB-
cord-297078-pxggjaby	20	24	,	,	,
cord-297078-pxggjaby	20	25	possibly	possibly	RB
cord-297078-pxggjaby	20	26	even	even	RB
cord-297078-pxggjaby	20	27	before	before	IN
cord-297078-pxggjaby	20	28	RNA	RNA	NNP
cord-297078-pxggjaby	20	29	(	(	-LRB-
cord-297078-pxggjaby	20	30	Dworkin	Dworkin	NNP
cord-297078-pxggjaby	20	31	,	,	,
cord-297078-pxggjaby	20	32	Lazcano	Lazcano	NNP
cord-297078-pxggjaby	20	33	,	,	,
cord-297078-pxggjaby	20	34	and	and	CC
cord-297078-pxggjaby	20	35	Miller	Miller	NNP
cord-297078-pxggjaby	20	36	2003	2003	CD
cord-297078-pxggjaby	20	37	)	)	-RRB-
cord-297078-pxggjaby	21	1	-see	-see	:
cord-297078-pxggjaby	21	2	legend	legend	NN
cord-297078-pxggjaby	21	3	to	to	TO
cord-297078-pxggjaby	21	4	figure	figure	VB
cord-297078-pxggjaby	21	5	1	1	CD
cord-297078-pxggjaby	21	6	.	.	.
cord-297078-pxggjaby	22	1	While	while	IN
cord-297078-pxggjaby	22	2	feasible	feasible	JJ
cord-297078-pxggjaby	22	3	,	,	,
cord-297078-pxggjaby	22	4	there	there	EX
cord-297078-pxggjaby	22	5	are	be	VBP
cord-297078-pxggjaby	22	6	no	no	DT
cord-297078-pxggjaby	22	7	indications	indication	NNS
cord-297078-pxggjaby	22	8	from	from	IN
cord-297078-pxggjaby	22	9	extant	extant	JJ
cord-297078-pxggjaby	22	10	organisms	organism	NNS
cord-297078-pxggjaby	22	11	that	that	WDT
cord-297078-pxggjaby	22	12	DNA	DNA	NNP
cord-297078-pxggjaby	22	13	took	take	VBD
cord-297078-pxggjaby	22	14	on	on	RP
cord-297078-pxggjaby	22	15	a	a	DT
cord-297078-pxggjaby	22	16	biological	biological	JJ
cord-297078-pxggjaby	22	17	role	role	NN
cord-297078-pxggjaby	22	18	at	at	IN
cord-297078-pxggjaby	22	19	such	such	PDT
cord-297078-pxggjaby	22	20	an	an	DT
cord-297078-pxggjaby	22	21	early	early	JJ
cord-297078-pxggjaby	22	22	stage	stage	NN
cord-297078-pxggjaby	22	23	(	(	-LRB-
cord-297078-pxggjaby	22	24	Poole	Poole	NNP
cord-297078-pxggjaby	22	25	,	,	,
cord-297078-pxggjaby	22	26	Logan	Logan	NNP
cord-297078-pxggjaby	22	27	,	,	,
cord-297078-pxggjaby	22	28	and	and	CC
cord-297078-pxggjaby	22	29	Sjöberg	Sjöberg	NNP
cord-297078-pxggjaby	22	30	2002	2002	CD
cord-297078-pxggjaby	22	31	)	)	-RRB-
cord-297078-pxggjaby	22	32	,	,	,
cord-297078-pxggjaby	22	33	and	and	CC
cord-297078-pxggjaby	22	34	we	-PRON-	PRP
cord-297078-pxggjaby	22	35	shall	shall	MD
cord-297078-pxggjaby	22	36	not	not	RB
cord-297078-pxggjaby	22	37	discuss	discuss	VB
cord-297078-pxggjaby	22	38	this	this	DT
cord-297078-pxggjaby	22	39	further	further	RB
cord-297078-pxggjaby	22	40	.	.	.
cord-297078-pxggjaby	23	1	Biochemical	biochemical	JJ
cord-297078-pxggjaby	23	2	data	datum	NNS
cord-297078-pxggjaby	23	3	suggest	suggest	VBP
cord-297078-pxggjaby	23	4	that	that	IN
cord-297078-pxggjaby	23	5	DNA	DNA	NNP
cord-297078-pxggjaby	23	6	evolved	evolve	VBN
cord-297078-pxggjaby	23	7	after	after	IN
cord-297078-pxggjaby	23	8	proteins	protein	NNS
cord-297078-pxggjaby	23	9	,	,	,
cord-297078-pxggjaby	23	10	and	and	CC
cord-297078-pxggjaby	23	11	before	before	IN
cord-297078-pxggjaby	23	12	the	the	DT
cord-297078-pxggjaby	23	13	three	three	CD
cord-297078-pxggjaby	23	14	domains	domain	NNS
cord-297078-pxggjaby	23	15	-	-	:
cord-297078-pxggjaby	23	16	archaea	archaea	NNS
cord-297078-pxggjaby	23	17	,	,	,
cord-297078-pxggjaby	23	18	bacteria	bacteria	NNS
cord-297078-pxggjaby	23	19	,	,	,
cord-297078-pxggjaby	23	20	and	and	CC
cord-297078-pxggjaby	23	21	eukaryotes	eukaryote	NNS
cord-297078-pxggjaby	23	22	-	-	,
cord-297078-pxggjaby	23	23	diverged	diverge	VBN
cord-297078-pxggjaby	23	24	.	.	.
cord-297078-pxggjaby	24	1	In	in	IN
cord-297078-pxggjaby	24	2	all	all	DT
cord-297078-pxggjaby	24	3	organisms	organism	NNS
cord-297078-pxggjaby	24	4	that	that	WDT
cord-297078-pxggjaby	24	5	carry	carry	VBP
cord-297078-pxggjaby	24	6	out	out	RP
cord-297078-pxggjaby	24	7	de	de	FW
cord-297078-pxggjaby	24	8	novo	novo	NNP
cord-297078-pxggjaby	24	9	synthesis	synthesis	NN
cord-297078-pxggjaby	24	10	of	of	IN
cord-297078-pxggjaby	24	11	deoxyribonucleotides	deoxyribonucleotide	NNS
cord-297078-pxggjaby	24	12	,	,	,
cord-297078-pxggjaby	24	13	these	these	DT
cord-297078-pxggjaby	24	14	are	be	VBP
cord-297078-pxggjaby	24	15	formed	form	VBN
cord-297078-pxggjaby	24	16	by	by	IN
cord-297078-pxggjaby	24	17	reduction	reduction	NN
cord-297078-pxggjaby	24	18	of	of	IN
cord-297078-pxggjaby	24	19	ribonucleotides	ribonucleotide	NNS
cord-297078-pxggjaby	24	20	by	by	IN
cord-297078-pxggjaby	24	21	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	24	22	reductase	reductase	NN
cord-297078-pxggjaby	24	23	(	(	-LRB-
cord-297078-pxggjaby	24	24	Poole	Poole	NNP
cord-297078-pxggjaby	24	25	,	,	,
cord-297078-pxggjaby	24	26	Logan	Logan	NNP
cord-297078-pxggjaby	24	27	,	,	,
cord-297078-pxggjaby	24	28	and	and	CC
cord-297078-pxggjaby	24	29	Sjöberg	Sjöberg	NNP
cord-297078-pxggjaby	24	30	2002	2002	CD
cord-297078-pxggjaby	24	31	)	)	-RRB-
cord-297078-pxggjaby	24	32	.	.	.
cord-297078-pxggjaby	25	1	Crystal	crystal	NN
cord-297078-pxggjaby	25	2	structures	structure	NNS
cord-297078-pxggjaby	25	3	of	of	IN
cord-297078-pxggjaby	25	4	the	the	DT
cord-297078-pxggjaby	25	5	catalytic	catalytic	JJ
cord-297078-pxggjaby	25	6	subunits	subunit	NNS
cord-297078-pxggjaby	25	7	of	of	IN
cord-297078-pxggjaby	25	8	the	the	DT
cord-297078-pxggjaby	25	9	three	three	CD
cord-297078-pxggjaby	25	10	divergent	divergent	JJ
cord-297078-pxggjaby	25	11	classes	class	NNS
cord-297078-pxggjaby	25	12	of	of	IN
cord-297078-pxggjaby	25	13	this	this	DT
cord-297078-pxggjaby	25	14	enzyme	enzyme	NN
cord-297078-pxggjaby	25	15	demonstrate	demonstrate	VBP
cord-297078-pxggjaby	25	16	a	a	DT
cord-297078-pxggjaby	25	17	common	common	JJ
cord-297078-pxggjaby	25	18	origin	origin	NN
cord-297078-pxggjaby	25	19	(	(	-LRB-
cord-297078-pxggjaby	25	20	Uhlin	Uhlin	NNP
cord-297078-pxggjaby	25	21	and	and	CC
cord-297078-pxggjaby	25	22	Eklund	Eklund	NNP
cord-297078-pxggjaby	25	23	1994	1994	CD
cord-297078-pxggjaby	25	24	;	;	:
cord-297078-pxggjaby	25	25	Logan	Logan	NNP
cord-297078-pxggjaby	25	26	et	et	NNP
cord-297078-pxggjaby	25	27	al	al	NNP
cord-297078-pxggjaby	25	28	.	.	.
cord-297078-pxggjaby	25	29	1999	1999	CD
cord-297078-pxggjaby	25	30	;	;	:
cord-297078-pxggjaby	25	31	Sintchak	Sintchak	NNP
cord-297078-pxggjaby	25	32	et	et	NNP
cord-297078-pxggjaby	25	33	al	al	NNP
cord-297078-pxggjaby	25	34	.	.	.
cord-297078-pxggjaby	26	1	2002	2002	CD
cord-297078-pxggjaby	26	2	;	;	:
cord-297078-pxggjaby	26	3	Larsson	Larsson	NNP
cord-297078-pxggjaby	26	4	et	et	NNP
cord-297078-pxggjaby	26	5	al	al	NNP
cord-297078-pxggjaby	26	6	.	.	.
cord-297078-pxggjaby	26	7	2004	2004	CD
cord-297078-pxggjaby	26	8	)	)	-RRB-
cord-297078-pxggjaby	26	9	,	,	.
cord-297078-pxggjaby	27	1	suggesting	suggest	VBG
cord-297078-pxggjaby	27	2	that	that	IN
cord-297078-pxggjaby	27	3	the	the	DT
cord-297078-pxggjaby	27	4	Last	last	JJ
cord-297078-pxggjaby	27	5	Universal	Universal	NNP
cord-297078-pxggjaby	27	6	Common	Common	NNP
cord-297078-pxggjaby	27	7	Ancestor	Ancestor	NNP
cord-297078-pxggjaby	27	8	(	(	-LRB-
cord-297078-pxggjaby	27	9	LUCA	LUCA	NNP
cord-297078-pxggjaby	27	10	)	)	-RRB-
cord-297078-pxggjaby	27	11	of	of	IN
cord-297078-pxggjaby	27	12	archaea	archaea	NNS
cord-297078-pxggjaby	27	13	,	,	,
cord-297078-pxggjaby	27	14	bacteria	bacteria	NNS
cord-297078-pxggjaby	27	15	,	,	,
cord-297078-pxggjaby	27	16	and	and	CC
cord-297078-pxggjaby	27	17	eukaryotes	eukaryote	NNS
cord-297078-pxggjaby	27	18	had	have	VBD
cord-297078-pxggjaby	27	19	a	a	DT
cord-297078-pxggjaby	27	20	DNA	dna	NN
cord-297078-pxggjaby	27	21	genome	genome	NN
cord-297078-pxggjaby	27	22	.	.	.
cord-297078-pxggjaby	28	1	In	in	IN
cord-297078-pxggjaby	28	2	contrast	contrast	NN
cord-297078-pxggjaby	28	3	,	,	,
cord-297078-pxggjaby	28	4	structural	structural	JJ
cord-297078-pxggjaby	28	5	and	and	CC
cord-297078-pxggjaby	28	6	phylogenomic	phylogenomic	JJ
cord-297078-pxggjaby	28	7	studies	study	NNS
cord-297078-pxggjaby	28	8	of	of	IN
cord-297078-pxggjaby	28	9	the	the	DT
cord-297078-pxggjaby	28	10	replication	replication	NN
cord-297078-pxggjaby	28	11	apparatus	apparatus	NN
cord-297078-pxggjaby	28	12	demonstrate	demonstrate	VBP
cord-297078-pxggjaby	28	13	that	that	IN
cord-297078-pxggjaby	28	14	numerous	numerous	JJ
cord-297078-pxggjaby	28	15	key	key	JJ
cord-297078-pxggjaby	28	16	components	component	NNS
cord-297078-pxggjaby	28	17	(	(	-LRB-
cord-297078-pxggjaby	28	18	notably	notably	RB
cord-297078-pxggjaby	28	19	DNA	DNA	NNP
cord-297078-pxggjaby	28	20	polymerases	polymerase	NNS
cord-297078-pxggjaby	28	21	and	and	CC
cord-297078-pxggjaby	28	22	primases	primase	NNS
cord-297078-pxggjaby	28	23	,	,	,
cord-297078-pxggjaby	28	24	see	see	VB
cord-297078-pxggjaby	28	25	Leipe	Leipe	NNP
cord-297078-pxggjaby	28	26	,	,	,
cord-297078-pxggjaby	28	27	Aravind	Aravind	NNP
cord-297078-pxggjaby	28	28	,	,	,
cord-297078-pxggjaby	28	29	and	and	CC
cord-297078-pxggjaby	28	30	Koonin	Koonin	NNP
cord-297078-pxggjaby	28	31	[	[	-LRB-
cord-297078-pxggjaby	28	32	1999	1999	CD
cord-297078-pxggjaby	28	33	]	]	-RRB-
cord-297078-pxggjaby	28	34	for	for	IN
cord-297078-pxggjaby	28	35	a	a	DT
cord-297078-pxggjaby	28	36	full	full	JJ
cord-297078-pxggjaby	28	37	list	list	NN
cord-297078-pxggjaby	28	38	)	)	-RRB-
cord-297078-pxggjaby	28	39	evolved	evolve	VBD
cord-297078-pxggjaby	28	40	twice	twice	RB
cord-297078-pxggjaby	28	41	,	,	,
cord-297078-pxggjaby	28	42	the	the	DT
cord-297078-pxggjaby	28	43	bacterial	bacterial	JJ
cord-297078-pxggjaby	28	44	apparatus	apparatus	NN
cord-297078-pxggjaby	28	45	being	be	VBG
cord-297078-pxggjaby	28	46	largely	largely	RB
cord-297078-pxggjaby	28	47	unrelated	unrelated	JJ
cord-297078-pxggjaby	28	48	to	to	IN
cord-297078-pxggjaby	28	49	the	the	DT
cord-297078-pxggjaby	28	50	archaeal	archaeal	JJ
cord-297078-pxggjaby	28	51	/	/	SYM
cord-297078-pxggjaby	28	52	eukaryotic	eukaryotic	JJ
cord-297078-pxggjaby	28	53	apparatus	apparatus	NN
cord-297078-pxggjaby	28	54	(	(	-LRB-
cord-297078-pxggjaby	28	55	Leipe	Leipe	NNP
cord-297078-pxggjaby	28	56	,	,	,
cord-297078-pxggjaby	28	57	Aravind	Aravind	NNP
cord-297078-pxggjaby	28	58	,	,	,
cord-297078-pxggjaby	28	59	and	and	CC
cord-297078-pxggjaby	28	60	Koonin	Koonin	NNP
cord-297078-pxggjaby	28	61	1999	1999	CD
cord-297078-pxggjaby	28	62	;	;	:
cord-297078-pxggjaby	28	63	Forterre	Forterre	NNP
cord-297078-pxggjaby	28	64	2002	2002	CD
cord-297078-pxggjaby	28	65	;	;	:
cord-297078-pxggjaby	28	66	Forterre	Forterre	NNP
cord-297078-pxggjaby	28	67	,	,	,
cord-297078-pxggjaby	28	68	Filée	Filée	NNP
cord-297078-pxggjaby	28	69	,	,	,
cord-297078-pxggjaby	28	70	and	and	CC
cord-297078-pxggjaby	28	71	Myllykallio	Myllykallio	NNP
cord-297078-pxggjaby	28	72	2004	2004	CD
cord-297078-pxggjaby	28	73	)	)	-RRB-
cord-297078-pxggjaby	28	74	.	.	.
cord-297078-pxggjaby	29	1	Consistent	consistent	JJ
cord-297078-pxggjaby	29	2	with	with	IN
cord-297078-pxggjaby	29	3	this	this	DT
cord-297078-pxggjaby	29	4	,	,	,
cord-297078-pxggjaby	29	5	a	a	DT
cord-297078-pxggjaby	29	6	recent	recent	JJ
cord-297078-pxggjaby	29	7	attempt	attempt	NN
cord-297078-pxggjaby	29	8	to	to	TO
cord-297078-pxggjaby	29	9	reconstruct	reconstruct	VB
cord-297078-pxggjaby	29	10	the	the	DT
cord-297078-pxggjaby	29	11	conserved	conserve	VBN
cord-297078-pxggjaby	29	12	core	core	NN
cord-297078-pxggjaby	29	13	of	of	IN
cord-297078-pxggjaby	29	14	LUCA	LUCA	NNP
cord-297078-pxggjaby	29	15	identified	identify	VBD
cord-297078-pxggjaby	29	16	only	only	RB
cord-297078-pxggjaby	29	17	four	four	CD
cord-297078-pxggjaby	29	18	universal	universal	JJ
cord-297078-pxggjaby	29	19	components	component	NNS
cord-297078-pxggjaby	29	20	of	of	IN
cord-297078-pxggjaby	29	21	modern	modern	JJ
cord-297078-pxggjaby	29	22	DNA	dna	NN
cord-297078-pxggjaby	29	23	replication	replication	NN
cord-297078-pxggjaby	29	24	and	and	CC
cord-297078-pxggjaby	29	25	repair	repair	NN
cord-297078-pxggjaby	29	26	(	(	-LRB-
cord-297078-pxggjaby	29	27	DnaN	dnan	XX
cord-297078-pxggjaby	29	28	:	:	:
cord-297078-pxggjaby	29	29	the	the	DT
cord-297078-pxggjaby	29	30	sliding	slide	VBG
cord-297078-pxggjaby	29	31	clamp	clamp	NN
cord-297078-pxggjaby	29	32	;	;	:
cord-297078-pxggjaby	29	33	HolB	holb	NN
cord-297078-pxggjaby	29	34	:	:	:
cord-297078-pxggjaby	29	35	the	the	DT
cord-297078-pxggjaby	29	36	clamp	clamp	NN
cord-297078-pxggjaby	29	37	loader	loader	NN
cord-297078-pxggjaby	29	38	;	;	:
cord-297078-pxggjaby	29	39	PolI	poli	NN
cord-297078-pxggjaby	29	40	-	-	HYPH
cord-297078-pxggjaby	29	41	A	A	NNP
cord-297078-pxggjaby	29	42	:	:	:
cord-297078-pxggjaby	29	43	the	the	DT
cord-297078-pxggjaby	29	44	3#-5	3#-5	NNP
cord-297078-pxggjaby	29	45	#	#	NN
cord-297078-pxggjaby	29	46	exonuclease	exonuclease	NN
cord-297078-pxggjaby	29	47	subunit	subunit	NN
cord-297078-pxggjaby	29	48	of	of	IN
cord-297078-pxggjaby	29	49	DNA	DNA	NNP
cord-297078-pxggjaby	29	50	PolI	PolI	NNP
cord-297078-pxggjaby	29	51	;	;	:
cord-297078-pxggjaby	29	52	and	and	CC
cord-297078-pxggjaby	29	53	RecA	RecA	NNP
cord-297078-pxggjaby	29	54	:	:	:
cord-297078-pxggjaby	29	55	involved	involve	VBN
cord-297078-pxggjaby	29	56	in	in	IN
cord-297078-pxggjaby	29	57	recombination	recombination	NN
cord-297078-pxggjaby	29	58	repair	repair	NN
cord-297078-pxggjaby	29	59	)	)	-RRB-
cord-297078-pxggjaby	29	60	.	.	.
cord-297078-pxggjaby	30	1	Three	three	CD
cord-297078-pxggjaby	30	2	produced	produce	VBD
cord-297078-pxggjaby	30	3	trees	tree	NNS
cord-297078-pxggjaby	30	4	congruent	congruent	JJ
cord-297078-pxggjaby	30	5	with	with	IN
cord-297078-pxggjaby	30	6	16	16	CD
cord-297078-pxggjaby	30	7	-	-	HYPH
cord-297078-pxggjaby	30	8	18S	18s	JJ
cord-297078-pxggjaby	30	9	ribosomal	ribosomal	NN
cord-297078-pxggjaby	30	10	RNA	RNA	NNP
cord-297078-pxggjaby	30	11	(	(	-LRB-
cord-297078-pxggjaby	30	12	rRNA	rrna	NN
cord-297078-pxggjaby	30	13	)	)	-RRB-
cord-297078-pxggjaby	30	14	trees	tree	NNS
cord-297078-pxggjaby	30	15	,	,	,
cord-297078-pxggjaby	30	16	while	while	IN
cord-297078-pxggjaby	30	17	HolB	HolB	NNP
cord-297078-pxggjaby	30	18	was	be	VBD
cord-297078-pxggjaby	30	19	argued	argue	VBN
cord-297078-pxggjaby	30	20	to	to	TO
cord-297078-pxggjaby	30	21	have	have	VB
cord-297078-pxggjaby	30	22	been	be	VBN
cord-297078-pxggjaby	30	23	subject	subject	JJ
cord-297078-pxggjaby	30	24	to	to	IN
cord-297078-pxggjaby	30	25	horizontal	horizontal	JJ
cord-297078-pxggjaby	30	26	gene	gene	NN
cord-297078-pxggjaby	30	27	transfer	transfer	NN
cord-297078-pxggjaby	31	1	(	(	-LRB-
cord-297078-pxggjaby	31	2	Harris	Harris	NNP
cord-297078-pxggjaby	31	3	et	et	NNP
cord-297078-pxggjaby	31	4	al	al	NNP
cord-297078-pxggjaby	31	5	.	.	NNP
cord-297078-pxggjaby	31	6	2003	2003	CD
cord-297078-pxggjaby	31	7	)	)	-RRB-
cord-297078-pxggjaby	31	8	.	.	.
cord-297078-pxggjaby	32	1	It	-PRON-	PRP
cord-297078-pxggjaby	32	2	is	be	VBZ
cord-297078-pxggjaby	32	3	therefore	therefore	RB
cord-297078-pxggjaby	32	4	unclear	unclear	JJ
cord-297078-pxggjaby	32	5	whether	whether	IN
cord-297078-pxggjaby	32	6	DNA	DNA	NNP
cord-297078-pxggjaby	32	7	appeared	appear	VBD
cord-297078-pxggjaby	32	8	before	before	IN
cord-297078-pxggjaby	32	9	LUCA	LUCA	NNP
cord-297078-pxggjaby	32	10	(	(	-LRB-
cord-297078-pxggjaby	32	11	as	as	IN
cord-297078-pxggjaby	32	12	is	be	VBZ
cord-297078-pxggjaby	32	13	commonly	commonly	RB
cord-297078-pxggjaby	32	14	assumed	assume	VBN
cord-297078-pxggjaby	32	15	)	)	-RRB-
cord-297078-pxggjaby	32	16	Poole	Poole	NNP
cord-297078-pxggjaby	32	17	,	,	,
cord-297078-pxggjaby	32	18	Penny	Penny	NNP
cord-297078-pxggjaby	32	19	,	,	,
cord-297078-pxggjaby	32	20	and	and	CC
cord-297078-pxggjaby	32	21	Sjöberg	Sjöberg	NNP
cord-297078-pxggjaby	32	22	2000	2000	CD
cord-297078-pxggjaby	32	23	)	)	-RRB-
cord-297078-pxggjaby	32	24	or	or	CC
cord-297078-pxggjaby	32	25	after	after	IN
cord-297078-pxggjaby	32	26	LUCA	LUCA	NNP
cord-297078-pxggjaby	32	27	(	(	-LRB-
cord-297078-pxggjaby	32	28	suggesting	suggest	VBG
cord-297078-pxggjaby	32	29	LUCA	LUCA	NNP
cord-297078-pxggjaby	32	30	contained	contain	VBD
cord-297078-pxggjaby	32	31	an	an	DT
cord-297078-pxggjaby	32	32	RNA	RNA	NNP
cord-297078-pxggjaby	32	33	or	or	CC
cord-297078-pxggjaby	32	34	possibly	possibly	RB
cord-297078-pxggjaby	32	35	an	an	DT
cord-297078-pxggjaby	32	36	RNA/	rna/	JJ
cord-297078-pxggjaby	32	37	DNA	dna	NN
cord-297078-pxggjaby	32	38	genome	genome	NN
cord-297078-pxggjaby	33	1	[	[	-LRB-
cord-297078-pxggjaby	33	2	Leipe	Leipe	NNP
cord-297078-pxggjaby	33	3	,	,	,
cord-297078-pxggjaby	33	4	Aravind	Aravind	NNP
cord-297078-pxggjaby	33	5	,	,	,
cord-297078-pxggjaby	33	6	and	and	CC
cord-297078-pxggjaby	33	7	Koonin	Koonin	NNP
cord-297078-pxggjaby	33	8	1999	1999	CD
cord-297078-pxggjaby	33	9	;	;	:
cord-297078-pxggjaby	33	10	Forterre	Forterre	NNP
cord-297078-pxggjaby	33	11	2002	2002	CD
cord-297078-pxggjaby	33	12	]	]	-RRB-
cord-297078-pxggjaby	33	13	)	)	-RRB-
cord-297078-pxggjaby	33	14	.	.	.
cord-297078-pxggjaby	34	1	To	to	TO
cord-297078-pxggjaby	34	2	clarify	clarify	VB
cord-297078-pxggjaby	34	3	,	,	,
cord-297078-pxggjaby	34	4	if	if	IN
cord-297078-pxggjaby	34	5	DNA	DNA	NNP
cord-297078-pxggjaby	34	6	was	be	VBD
cord-297078-pxggjaby	34	7	the	the	DT
cord-297078-pxggjaby	34	8	genetic	genetic	JJ
cord-297078-pxggjaby	34	9	material	material	NN
cord-297078-pxggjaby	34	10	in	in	IN
cord-297078-pxggjaby	34	11	LUCA	LUCA	NNP
cord-297078-pxggjaby	34	12	,	,	,
cord-297078-pxggjaby	34	13	it	-PRON-	PRP
cord-297078-pxggjaby	34	14	seems	seem	VBZ
cord-297078-pxggjaby	34	15	likely	likely	JJ
cord-297078-pxggjaby	34	16	that	that	IN
cord-297078-pxggjaby	34	17	one	one	CD
cord-297078-pxggjaby	34	18	of	of	IN
cord-297078-pxggjaby	34	19	the	the	DT
cord-297078-pxggjaby	34	20	two	two	CD
cord-297078-pxggjaby	34	21	forms	form	NNS
cord-297078-pxggjaby	34	22	of	of	IN
cord-297078-pxggjaby	34	23	replication	replication	NN
cord-297078-pxggjaby	34	24	apparatus	apparatus	NN
cord-297078-pxggjaby	34	25	(	(	-LRB-
cord-297078-pxggjaby	34	26	either	either	CC
cord-297078-pxggjaby	34	27	bacterial	bacterial	JJ
cord-297078-pxggjaby	34	28	or	or	CC
cord-297078-pxggjaby	34	29	archaeal	archaeal	JJ
cord-297078-pxggjaby	34	30	/	/	SYM
cord-297078-pxggjaby	34	31	eukaryotic	eukaryotic	NN
cord-297078-pxggjaby	34	32	)	)	-RRB-
cord-297078-pxggjaby	34	33	was	be	VBD
cord-297078-pxggjaby	34	34	present	present	JJ
cord-297078-pxggjaby	34	35	at	at	IN
cord-297078-pxggjaby	34	36	this	this	DT
cord-297078-pxggjaby	34	37	stage	stage	NN
cord-297078-pxggjaby	34	38	,	,	,
cord-297078-pxggjaby	34	39	with	with	IN
cord-297078-pxggjaby	34	40	the	the	DT
cord-297078-pxggjaby	34	41	other	other	JJ
cord-297078-pxggjaby	34	42	form	form	NN
cord-297078-pxggjaby	34	43	representing	represent	VBG
cord-297078-pxggjaby	34	44	a	a	DT
cord-297078-pxggjaby	34	45	lineage	lineage	NN
cord-297078-pxggjaby	34	46	-	-	HYPH
cord-297078-pxggjaby	34	47	specific	specific	JJ
cord-297078-pxggjaby	34	48	replacement	replacement	NN
cord-297078-pxggjaby	34	49	(	(	-LRB-
cord-297078-pxggjaby	34	50	nonorthologous	nonorthologous	JJ
cord-297078-pxggjaby	34	51	gene	gene	NN
cord-297078-pxggjaby	34	52	displacement	displacement	NN
cord-297078-pxggjaby	34	53	[	[	-LRB-
cord-297078-pxggjaby	34	54	NOGD	NOGD	NNP
cord-297078-pxggjaby	34	55	]	]	-RRB-
cord-297078-pxggjaby	34	56	)	)	-RRB-
cord-297078-pxggjaby	34	57	.	.	.
cord-297078-pxggjaby	35	1	At	at	IN
cord-297078-pxggjaby	35	2	the	the	DT
cord-297078-pxggjaby	35	3	same	same	JJ
cord-297078-pxggjaby	35	4	time	time	NN
cord-297078-pxggjaby	35	5	,	,	,
cord-297078-pxggjaby	35	6	LUCA	LUCA	NNP
cord-297078-pxggjaby	35	7	must	must	MD
cord-297078-pxggjaby	35	8	have	have	VB
cord-297078-pxggjaby	35	9	carried	carry	VBN
cord-297078-pxggjaby	35	10	out	out	RP
cord-297078-pxggjaby	35	11	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	35	12	reduction	reduction	NN
cord-297078-pxggjaby	35	13	.	.	.
cord-297078-pxggjaby	36	1	Alternatively	alternatively	RB
cord-297078-pxggjaby	36	2	,	,	,
cord-297078-pxggjaby	36	3	LUCA	LUCA	NNP
cord-297078-pxggjaby	36	4	possessed	possess	VBD
cord-297078-pxggjaby	36	5	an	an	DT
cord-297078-pxggjaby	36	6	RNA	RNA	NNP
cord-297078-pxggjaby	36	7	genome	genome	NN
cord-297078-pxggjaby	36	8	,	,	,
cord-297078-pxggjaby	36	9	and	and	CC
cord-297078-pxggjaby	36	10	DNA	dna	NN
cord-297078-pxggjaby	36	11	replication	replication	NN
cord-297078-pxggjaby	36	12	evolved	evolve	VBD
cord-297078-pxggjaby	36	13	twice	twice	RB
cord-297078-pxggjaby	36	14	independently	independently	RB
cord-297078-pxggjaby	36	15	(	(	-LRB-
cord-297078-pxggjaby	36	16	Leipe	Leipe	NNP
cord-297078-pxggjaby	36	17	,	,	,
cord-297078-pxggjaby	36	18	Aravind	Aravind	NNP
cord-297078-pxggjaby	36	19	,	,	,
cord-297078-pxggjaby	36	20	and	and	CC
cord-297078-pxggjaby	36	21	Koonin	Koonin	NNP
cord-297078-pxggjaby	36	22	1999	1999	CD
cord-297078-pxggjaby	36	23	;	;	:
cord-297078-pxggjaby	36	24	Forterre	Forterre	NNP
cord-297078-pxggjaby	36	25	2002	2002	CD
cord-297078-pxggjaby	36	26	)	)	-RRB-
cord-297078-pxggjaby	36	27	.	.	.
cord-297078-pxggjaby	37	1	Leipe	Leipe	NNS
cord-297078-pxggjaby	37	2	,	,	,
cord-297078-pxggjaby	37	3	Aravind	Aravind	NNP
cord-297078-pxggjaby	37	4	,	,	,
cord-297078-pxggjaby	37	5	and	and	CC
cord-297078-pxggjaby	37	6	Koonin	Koonin	NNP
cord-297078-pxggjaby	37	7	(	(	-LRB-
cord-297078-pxggjaby	37	8	1999	1999	CD
cord-297078-pxggjaby	37	9	)	)	-RRB-
cord-297078-pxggjaby	37	10	suggest	suggest	VBP
cord-297078-pxggjaby	37	11	that	that	IN
cord-297078-pxggjaby	37	12	LUCA	LUCA	NNP
cord-297078-pxggjaby	37	13	possessed	possess	VBD
cord-297078-pxggjaby	37	14	a	a	DT
cord-297078-pxggjaby	37	15	hybrid	hybrid	JJ
cord-297078-pxggjaby	37	16	DNA	DNA	NNP
cord-297078-pxggjaby	37	17	/	/	SYM
cord-297078-pxggjaby	37	18	RNA	RNA	NNP
cord-297078-pxggjaby	37	19	genome	genome	NN
cord-297078-pxggjaby	37	20	,	,	,
cord-297078-pxggjaby	37	21	thereby	thereby	RB
cord-297078-pxggjaby	37	22	providing	provide	VBG
cord-297078-pxggjaby	37	23	an	an	DT
cord-297078-pxggjaby	37	24	explanation	explanation	NN
cord-297078-pxggjaby	37	25	for	for	IN
cord-297078-pxggjaby	37	26	the	the	DT
cord-297078-pxggjaby	37	27	universal	universal	JJ
cord-297078-pxggjaby	37	28	distribution	distribution	NN
cord-297078-pxggjaby	37	29	of	of	IN
cord-297078-pxggjaby	37	30	certain	certain	JJ
cord-297078-pxggjaby	37	31	components	component	NNS
cord-297078-pxggjaby	37	32	of	of	IN
cord-297078-pxggjaby	37	33	the	the	DT
cord-297078-pxggjaby	37	34	DNA	dna	NN
cord-297078-pxggjaby	37	35	replication	replication	NN
cord-297078-pxggjaby	37	36	/	/	SYM
cord-297078-pxggjaby	37	37	repair	repair	NN
cord-297078-pxggjaby	37	38	apparatus	apparatus	NN
cord-297078-pxggjaby	37	39	.	.	.
cord-297078-pxggjaby	38	1	This	this	DT
cord-297078-pxggjaby	38	2	model	model	NN
cord-297078-pxggjaby	38	3	requires	require	VBZ
cord-297078-pxggjaby	38	4	that	that	IN
cord-297078-pxggjaby	38	5	a	a	DT
cord-297078-pxggjaby	38	6	reverse	reverse	JJ
cord-297078-pxggjaby	38	7	transcriptase	transcriptase	NN
cord-297078-pxggjaby	38	8	activity	activity	NN
cord-297078-pxggjaby	38	9	was	be	VBD
cord-297078-pxggjaby	38	10	present	present	JJ
cord-297078-pxggjaby	38	11	in	in	IN
cord-297078-pxggjaby	38	12	some	some	DT
cord-297078-pxggjaby	38	13	form	form	NN
cord-297078-pxggjaby	38	14	,	,	,
cord-297078-pxggjaby	38	15	though	though	IN
cord-297078-pxggjaby	38	16	no	no	DT
cord-297078-pxggjaby	38	17	direct	direct	JJ
cord-297078-pxggjaby	38	18	evidence	evidence	NN
cord-297078-pxggjaby	38	19	for	for	IN
cord-297078-pxggjaby	38	20	this	this	DT
cord-297078-pxggjaby	38	21	function	function	NN
cord-297078-pxggjaby	38	22	in	in	IN
cord-297078-pxggjaby	38	23	LUCA	LUCA	NNP
cord-297078-pxggjaby	38	24	is	be	VBZ
cord-297078-pxggjaby	38	25	available	available	JJ
cord-297078-pxggjaby	38	26	.	.	.
cord-297078-pxggjaby	39	1	Furthermore	furthermore	RB
cord-297078-pxggjaby	39	2	,	,	,
cord-297078-pxggjaby	39	3	although	although	IN
cord-297078-pxggjaby	39	4	the	the	DT
cord-297078-pxggjaby	39	5	model	model	NN
cord-297078-pxggjaby	39	6	aims	aim	VBZ
cord-297078-pxggjaby	39	7	to	to	TO
cord-297078-pxggjaby	39	8	explain	explain	VB
cord-297078-pxggjaby	39	9	the	the	DT
cord-297078-pxggjaby	39	10	presence	presence	NN
cord-297078-pxggjaby	39	11	of	of	IN
cord-297078-pxggjaby	39	12	key	key	JJ
cord-297078-pxggjaby	39	13	components	component	NNS
cord-297078-pxggjaby	39	14	of	of	IN
cord-297078-pxggjaby	39	15	the	the	DT
cord-297078-pxggjaby	39	16	modern	modern	JJ
cord-297078-pxggjaby	39	17	DNA	dna	NN
cord-297078-pxggjaby	39	18	apparatus	apparatus	NN
cord-297078-pxggjaby	39	19	in	in	IN
cord-297078-pxggjaby	39	20	LUCA	LUCA	NNP
cord-297078-pxggjaby	39	21	,	,	,
cord-297078-pxggjaby	39	22	by	by	IN
cord-297078-pxggjaby	39	23	their	-PRON-	PRP$
cord-297078-pxggjaby	39	24	own	own	JJ
cord-297078-pxggjaby	39	25	admission	admission	NN
cord-297078-pxggjaby	39	26	,	,	,
cord-297078-pxggjaby	39	27	the	the	DT
cord-297078-pxggjaby	39	28	authors	author	NNS
cord-297078-pxggjaby	39	29	'	'	POS
cord-297078-pxggjaby	39	30	model	model	NN
cord-297078-pxggjaby	39	31	does	do	VBZ
cord-297078-pxggjaby	39	32	not	not	RB
cord-297078-pxggjaby	39	33	actually	actually	RB
cord-297078-pxggjaby	39	34	provide	provide	VB
cord-297078-pxggjaby	39	35	roles	role	NNS
cord-297078-pxggjaby	39	36	for	for	IN
cord-297078-pxggjaby	39	37	most	most	JJS
cord-297078-pxggjaby	39	38	of	of	IN
cord-297078-pxggjaby	39	39	these	these	DT
cord-297078-pxggjaby	39	40	,	,	,
cord-297078-pxggjaby	39	41	including	include	VBG
cord-297078-pxggjaby	39	42	critical	critical	JJ
cord-297078-pxggjaby	39	43	components	component	NNS
cord-297078-pxggjaby	39	44	such	such	JJ
cord-297078-pxggjaby	39	45	as	as	IN
cord-297078-pxggjaby	39	46	the	the	DT
cord-297078-pxggjaby	39	47	sliding	slide	VBG
cord-297078-pxggjaby	39	48	clamp	clamp	NN
cord-297078-pxggjaby	39	49	,	,	,
cord-297078-pxggjaby	39	50	clamp	clamp	NN
cord-297078-pxggjaby	39	51	loader	loader	NN
cord-297078-pxggjaby	39	52	,	,	,
cord-297078-pxggjaby	39	53	ligase	ligase	NN
cord-297078-pxggjaby	39	54	,	,	,
cord-297078-pxggjaby	39	55	and	and	CC
cord-297078-pxggjaby	39	56	topoisomerase	topoisomerase	NN
cord-297078-pxggjaby	39	57	I.	i.	NN
cord-297078-pxggjaby	40	1	At	at	IN
cord-297078-pxggjaby	40	2	first	first	JJ
cord-297078-pxggjaby	40	3	glance	glance	NN
cord-297078-pxggjaby	40	4	,	,	,
cord-297078-pxggjaby	40	5	it	-PRON-	PRP
cord-297078-pxggjaby	40	6	would	would	MD
cord-297078-pxggjaby	40	7	appear	appear	VB
cord-297078-pxggjaby	40	8	that	that	IN
cord-297078-pxggjaby	40	9	the	the	DT
cord-297078-pxggjaby	40	10	data	datum	NNS
cord-297078-pxggjaby	40	11	emerging	emerge	VBG
cord-297078-pxggjaby	40	12	from	from	IN
cord-297078-pxggjaby	40	13	studies	study	NNS
cord-297078-pxggjaby	40	14	of	of	IN
cord-297078-pxggjaby	40	15	the	the	DT
cord-297078-pxggjaby	40	16	DNA	dna	NN
cord-297078-pxggjaby	40	17	replication	replication	NN
cord-297078-pxggjaby	40	18	apparatus	apparatus	NN
cord-297078-pxggjaby	40	19	and	and	CC
cord-297078-pxggjaby	40	20	that	that	IN
cord-297078-pxggjaby	40	21	for	for	IN
cord-297078-pxggjaby	40	22	deoxyribonucleotide	deoxyribonucleotide	JJ
cord-297078-pxggjaby	40	23	synthesis	synthesis	NN
cord-297078-pxggjaby	40	24	are	be	VBP
cord-297078-pxggjaby	40	25	in	in	IN
cord-297078-pxggjaby	40	26	conflict	conflict	NN
cord-297078-pxggjaby	40	27	.	.	.
cord-297078-pxggjaby	41	1	However	however	RB
cord-297078-pxggjaby	41	2	,	,	,
cord-297078-pxggjaby	41	3	while	while	IN
cord-297078-pxggjaby	41	4	a	a	DT
cord-297078-pxggjaby	41	5	single	single	JJ
cord-297078-pxggjaby	41	6	evolutionary	evolutionary	JJ
cord-297078-pxggjaby	41	7	origin	origin	NN
cord-297078-pxggjaby	41	8	for	for	IN
cord-297078-pxggjaby	41	9	the	the	DT
cord-297078-pxggjaby	41	10	catalytic	catalytic	JJ
cord-297078-pxggjaby	41	11	subunit	subunit	NN
cord-297078-pxggjaby	41	12	of	of	IN
cord-297078-pxggjaby	41	13	the	the	DT
cord-297078-pxggjaby	41	14	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	41	15	reductases	reductases	NNP
cord-297078-pxggjaby	41	16	is	be	VBZ
cord-297078-pxggjaby	41	17	established	establish	VBN
cord-297078-pxggjaby	41	18	,	,	,
cord-297078-pxggjaby	41	19	its	-PRON-	PRP$
cord-297078-pxggjaby	41	20	evolutionary	evolutionary	JJ
cord-297078-pxggjaby	41	21	history	history	NN
cord-297078-pxggjaby	41	22	is	be	VBZ
cord-297078-pxggjaby	41	23	obscured	obscure	VBN
cord-297078-pxggjaby	41	24	(	(	-LRB-
cord-297078-pxggjaby	41	25	Poole	Poole	NNP
cord-297078-pxggjaby	41	26	,	,	,
cord-297078-pxggjaby	41	27	Logan	Logan	NNP
cord-297078-pxggjaby	41	28	,	,	,
cord-297078-pxggjaby	41	29	and	and	CC
cord-297078-pxggjaby	41	30	Sjöberg	Sjöberg	NNP
cord-297078-pxggjaby	41	31	2002	2002	CD
cord-297078-pxggjaby	41	32	)	)	-RRB-
cord-297078-pxggjaby	41	33	.	.	.
cord-297078-pxggjaby	42	1	There	there	EX
cord-297078-pxggjaby	42	2	are	be	VBP
cord-297078-pxggjaby	42	3	several	several	JJ
cord-297078-pxggjaby	42	4	reasons	reason	NNS
cord-297078-pxggjaby	42	5	for	for	IN
cord-297078-pxggjaby	42	6	this	this	DT
cord-297078-pxggjaby	42	7	.	.	.
cord-297078-pxggjaby	43	1	First	first	RB
cord-297078-pxggjaby	43	2	,	,	,
cord-297078-pxggjaby	43	3	the	the	DT
cord-297078-pxggjaby	43	4	phylogenetic	phylogenetic	JJ
cord-297078-pxggjaby	43	5	distribution	distribution	NN
cord-297078-pxggjaby	43	6	of	of	IN
cord-297078-pxggjaby	43	7	the	the	DT
cord-297078-pxggjaby	43	8	paralogous	paralogous	JJ
cord-297078-pxggjaby	43	9	catalytic	catalytic	JJ
cord-297078-pxggjaby	43	10	subunits	subunit	NNS
cord-297078-pxggjaby	43	11	from	from	IN
cord-297078-pxggjaby	43	12	the	the	DT
cord-297078-pxggjaby	43	13	three	three	CD
cord-297078-pxggjaby	43	14	classes	class	NNS
cord-297078-pxggjaby	43	15	is	be	VBZ
cord-297078-pxggjaby	43	16	incomplete	incomplete	JJ
cord-297078-pxggjaby	43	17	.	.	.
cord-297078-pxggjaby	44	1	Bacteria	Bacteria	NNS
cord-297078-pxggjaby	44	2	as	as	IN
cord-297078-pxggjaby	44	3	a	a	DT
cord-297078-pxggjaby	44	4	domain	domain	NN
cord-297078-pxggjaby	44	5	possess	possess	VBP
cord-297078-pxggjaby	44	6	all	all	DT
cord-297078-pxggjaby	44	7	three	three	CD
cord-297078-pxggjaby	44	8	classes	class	NNS
cord-297078-pxggjaby	44	9	,	,	,
cord-297078-pxggjaby	44	10	archaea	archaea	NNP
cord-297078-pxggjaby	44	11	largely	largely	RB
cord-297078-pxggjaby	44	12	possess	possess	VBP
cord-297078-pxggjaby	44	13	class	class	NN
cord-297078-pxggjaby	44	14	II	II	NNP
cord-297078-pxggjaby	44	15	and	and	CC
cord-297078-pxggjaby	44	16	III	III	NNP
cord-297078-pxggjaby	44	17	reductases	reductase	NNS
cord-297078-pxggjaby	44	18	,	,	,
cord-297078-pxggjaby	44	19	and	and	CC
cord-297078-pxggjaby	44	20	eukaryotes	eukaryote	NNS
cord-297078-pxggjaby	44	21	thus	thus	RB
cord-297078-pxggjaby	44	22	far	far	RB
cord-297078-pxggjaby	44	23	possess	possess	VBP
cord-297078-pxggjaby	44	24	only	only	JJ
cord-297078-pxggjaby	44	25	class	class	NN
cord-297078-pxggjaby	44	26	I	-PRON-	PRP
cord-297078-pxggjaby	44	27	reductases	reductase	VBZ
cord-297078-pxggjaby	44	28	.	.	.
cord-297078-pxggjaby	45	1	Secondly	secondly	RB
cord-297078-pxggjaby	45	2	,	,	,
cord-297078-pxggjaby	45	3	the	the	DT
cord-297078-pxggjaby	45	4	reductases	reductase	NNS
cord-297078-pxggjaby	45	5	may	may	MD
cord-297078-pxggjaby	45	6	have	have	VB
cord-297078-pxggjaby	45	7	undergone	undergo	VBN
cord-297078-pxggjaby	45	8	horizontal	horizontal	JJ
cord-297078-pxggjaby	45	9	gene	gene	NN
cord-297078-pxggjaby	45	10	transfer	transfer	NN
cord-297078-pxggjaby	45	11	as	as	RB
cord-297078-pxggjaby	45	12	well	well	RB
cord-297078-pxggjaby	45	13	as	as	IN
cord-297078-pxggjaby	45	14	polyphyletic	polyphyletic	JJ
cord-297078-pxggjaby	45	15	losses	loss	NNS
cord-297078-pxggjaby	45	16	(	(	-LRB-
cord-297078-pxggjaby	45	17	Torrents	Torrents	NNP
cord-297078-pxggjaby	45	18	et	et	NNP
cord-297078-pxggjaby	45	19	al	al	NNP
cord-297078-pxggjaby	45	20	.	.	.
cord-297078-pxggjaby	45	21	2002	2002	CD
cord-297078-pxggjaby	45	22	)	)	-RRB-
cord-297078-pxggjaby	45	23	.	.	.
cord-297078-pxggjaby	46	1	While	while	IN
cord-297078-pxggjaby	46	2	the	the	DT
cord-297078-pxggjaby	46	3	three	three	CD
cord-297078-pxggjaby	46	4	classes	class	NNS
cord-297078-pxggjaby	46	5	perform	perform	VBP
cord-297078-pxggjaby	46	6	the	the	DT
cord-297078-pxggjaby	46	7	same	same	JJ
cord-297078-pxggjaby	46	8	reaction	reaction	NN
cord-297078-pxggjaby	46	9	,	,	,
cord-297078-pxggjaby	46	10	they	-PRON-	PRP
cord-297078-pxggjaby	46	11	do	do	VBP
cord-297078-pxggjaby	46	12	so	so	RB
cord-297078-pxggjaby	46	13	under	under	IN
cord-297078-pxggjaby	46	14	different	different	JJ
cord-297078-pxggjaby	46	15	oxygenic	oxygenic	JJ
cord-297078-pxggjaby	46	16	conditions	condition	NNS
cord-297078-pxggjaby	46	17	:	:	:
cord-297078-pxggjaby	46	18	class	class	NN
cord-297078-pxggjaby	47	1	I	-PRON-	PRP
cord-297078-pxggjaby	47	2	is	be	VBZ
cord-297078-pxggjaby	47	3	strictly	strictly	RB
cord-297078-pxggjaby	47	4	aerobic	aerobic	JJ
cord-297078-pxggjaby	47	5	,	,	,
cord-297078-pxggjaby	47	6	class	class	NN
cord-297078-pxggjaby	47	7	II	II	NNP
cord-297078-pxggjaby	47	8	is	be	VBZ
cord-297078-pxggjaby	47	9	operational	operational	JJ
cord-297078-pxggjaby	47	10	in	in	IN
cord-297078-pxggjaby	47	11	both	both	DT
cord-297078-pxggjaby	47	12	aerobic	aerobic	JJ
cord-297078-pxggjaby	47	13	and	and	CC
cord-297078-pxggjaby	47	14	anaerobic	anaerobic	JJ
cord-297078-pxggjaby	47	15	conditions	condition	NNS
cord-297078-pxggjaby	47	16	and	and	CC
cord-297078-pxggjaby	47	17	class	class	NN
cord-297078-pxggjaby	47	18	III	iii	CD
cord-297078-pxggjaby	48	1	is	be	VBZ
cord-297078-pxggjaby	48	2	strictly	strictly	RB
cord-297078-pxggjaby	48	3	anaerobic	anaerobic	JJ
cord-297078-pxggjaby	48	4	.	.	.
cord-297078-pxggjaby	49	1	Consequently	consequently	RB
cord-297078-pxggjaby	49	2	,	,	,
cord-297078-pxggjaby	49	3	many	many	JJ
cord-297078-pxggjaby	49	4	organisms	organism	NNS
cord-297078-pxggjaby	49	5	possess	possess	VBP
cord-297078-pxggjaby	49	6	more	more	JJR
cord-297078-pxggjaby	49	7	than	than	IN
cord-297078-pxggjaby	49	8	one	one	CD
cord-297078-pxggjaby	49	9	class	class	NN
cord-297078-pxggjaby	49	10	,	,	,
cord-297078-pxggjaby	49	11	and	and	CC
cord-297078-pxggjaby	49	12	gain	gain	NN
cord-297078-pxggjaby	49	13	and	and	CC
cord-297078-pxggjaby	49	14	loss	loss	NN
cord-297078-pxggjaby	49	15	of	of	IN
cord-297078-pxggjaby	49	16	reductases	reductase	NNS
cord-297078-pxggjaby	49	17	may	may	MD
cord-297078-pxggjaby	49	18	be	be	VB
cord-297078-pxggjaby	49	19	a	a	DT
cord-297078-pxggjaby	49	20	cause	cause	NN
cord-297078-pxggjaby	49	21	/	/	SYM
cord-297078-pxggjaby	49	22	consequence	consequence	NN
cord-297078-pxggjaby	49	23	of	of	IN
cord-297078-pxggjaby	49	24	changes	change	NNS
cord-297078-pxggjaby	49	25	in	in	IN
cord-297078-pxggjaby	49	26	habitat	habitat	NN
cord-297078-pxggjaby	49	27	.	.	.
cord-297078-pxggjaby	50	1	Third	third	RB
cord-297078-pxggjaby	50	2	,	,	,
cord-297078-pxggjaby	50	3	sequence	sequence	NN
cord-297078-pxggjaby	50	4	similarity	similarity	NN
cord-297078-pxggjaby	50	5	is	be	VBZ
cord-297078-pxggjaby	50	6	extremely	extremely	RB
cord-297078-pxggjaby	50	7	low	low	JJ
cord-297078-pxggjaby	50	8	between	between	IN
cord-297078-pxggjaby	50	9	the	the	DT
cord-297078-pxggjaby	50	10	classes	class	NNS
cord-297078-pxggjaby	50	11	(	(	-LRB-
cord-297078-pxggjaby	50	12	Tauer	Tauer	NNP
cord-297078-pxggjaby	50	13	and	and	CC
cord-297078-pxggjaby	50	14	Benner	Benner	NNP
cord-297078-pxggjaby	50	15	1997	1997	CD
cord-297078-pxggjaby	50	16	;	;	:
cord-297078-pxggjaby	50	17	Torrents	Torrents	NNP
cord-297078-pxggjaby	50	18	et	et	NNP
cord-297078-pxggjaby	50	19	al	al	NNP
cord-297078-pxggjaby	50	20	.	.	.
cord-297078-pxggjaby	50	21	2002	2002	CD
cord-297078-pxggjaby	50	22	)	)	-RRB-
cord-297078-pxggjaby	50	23	,	,	,
cord-297078-pxggjaby	50	24	making	make	VBG
cord-297078-pxggjaby	50	25	it	-PRON-	PRP
cord-297078-pxggjaby	50	26	unlikely	unlikely	JJ
cord-297078-pxggjaby	50	27	that	that	IN
cord-297078-pxggjaby	50	28	meaningful	meaningful	JJ
cord-297078-pxggjaby	50	29	phylogenetic	phylogenetic	JJ
cord-297078-pxggjaby	50	30	analyses	analysis	NNS
cord-297078-pxggjaby	50	31	can	can	MD
cord-297078-pxggjaby	50	32	be	be	VB
cord-297078-pxggjaby	50	33	carried	carry	VBN
cord-297078-pxggjaby	50	34	out	out	RP
cord-297078-pxggjaby	50	35	for	for	IN
cord-297078-pxggjaby	50	36	the	the	DT
cord-297078-pxggjaby	50	37	entire	entire	JJ
cord-297078-pxggjaby	50	38	data	data	NN
cord-297078-pxggjaby	50	39	set	set	NN
cord-297078-pxggjaby	50	40	.	.	.
cord-297078-pxggjaby	51	1	These	these	DT
cord-297078-pxggjaby	51	2	points	point	NNS
cord-297078-pxggjaby	51	3	,	,	,
cord-297078-pxggjaby	51	4	taken	take	VBN
cord-297078-pxggjaby	51	5	together	together	RB
cord-297078-pxggjaby	51	6	,	,	,
cord-297078-pxggjaby	51	7	make	make	VB
cord-297078-pxggjaby	51	8	it	-PRON-	PRP
cord-297078-pxggjaby	51	9	difficult	difficult	JJ
cord-297078-pxggjaby	51	10	to	to	TO
cord-297078-pxggjaby	51	11	establish	establish	VB
cord-297078-pxggjaby	51	12	the	the	DT
cord-297078-pxggjaby	51	13	timing	timing	NN
cord-297078-pxggjaby	51	14	of	of	IN
cord-297078-pxggjaby	51	15	their	-PRON-	PRP$
cord-297078-pxggjaby	51	16	emergence	emergence	NN
cord-297078-pxggjaby	51	17	(	(	-LRB-
cord-297078-pxggjaby	51	18	i.e.	i.e.	FW
cord-297078-pxggjaby	51	19	,	,	,
cord-297078-pxggjaby	51	20	pre	pre	JJ
cord-297078-pxggjaby	51	21	-	-	JJ
cord-297078-pxggjaby	51	22	or	or	CC
cord-297078-pxggjaby	51	23	post	post	JJ
cord-297078-pxggjaby	51	24	-	-	NN
cord-297078-pxggjaby	51	25	LUCA	LUCA	NNP
cord-297078-pxggjaby	51	26	)	)	-RRB-
cord-297078-pxggjaby	51	27	.	.	.
cord-297078-pxggjaby	52	1	Mirkin	Mirkin	NNP
cord-297078-pxggjaby	52	2	et	et	NNP
cord-297078-pxggjaby	52	3	al	al	NNP
cord-297078-pxggjaby	52	4	.	.	.
cord-297078-pxggjaby	53	1	(	(	-LRB-
cord-297078-pxggjaby	53	2	2003	2003	CD
cord-297078-pxggjaby	53	3	)	)	-RRB-
cord-297078-pxggjaby	53	4	have	have	VBP
cord-297078-pxggjaby	53	5	predicted	predict	VBN
cord-297078-pxggjaby	53	6	that	that	IN
cord-297078-pxggjaby	53	7	LUCA	LUCA	NNP
cord-297078-pxggjaby	53	8	possessed	possess	VBD
cord-297078-pxggjaby	53	9	500	500	CD
cord-297078-pxggjaby	53	10	-	-	SYM
cord-297078-pxggjaby	53	11	600	600	CD
cord-297078-pxggjaby	53	12	genes	gene	NNS
cord-297078-pxggjaby	53	13	.	.	.
cord-297078-pxggjaby	54	1	However	however	RB
cord-297078-pxggjaby	54	2	,	,	,
cord-297078-pxggjaby	54	3	a	a	DT
cord-297078-pxggjaby	54	4	genome	genome	NN
cord-297078-pxggjaby	54	5	of	of	IN
cord-297078-pxggjaby	54	6	this	this	DT
cord-297078-pxggjaby	54	7	size	size	NN
cord-297078-pxggjaby	54	8	may	may	MD
cord-297078-pxggjaby	54	9	be	be	VB
cord-297078-pxggjaby	54	10	too	too	RB
cord-297078-pxggjaby	54	11	large	large	JJ
cord-297078-pxggjaby	54	12	to	to	TO
cord-297078-pxggjaby	54	13	be	be	VB
cord-297078-pxggjaby	54	14	maintained	maintain	VBN
cord-297078-pxggjaby	54	15	as	as	IN
cord-297078-pxggjaby	54	16	RNA	RNA	NNP
cord-297078-pxggjaby	54	17	.	.	.
cord-297078-pxggjaby	55	1	Modern	Modern	NNP
cord-297078-pxggjaby	55	2	RNA	RNA	NNP
cord-297078-pxggjaby	55	3	polymerases	polymerase	NNS
cord-297078-pxggjaby	55	4	have	have	VBP
cord-297078-pxggjaby	55	5	a	a	DT
cord-297078-pxggjaby	55	6	fidelity	fidelity	NN
cord-297078-pxggjaby	55	7	of	of	IN
cord-297078-pxggjaby	55	8	;	;	:
cord-297078-pxggjaby	55	9	10	10	CD
cord-297078-pxggjaby	55	10	ÿ4	ÿ4	NNS
cord-297078-pxggjaby	55	11	,	,	,
cord-297078-pxggjaby	55	12	and	and	CC
cord-297078-pxggjaby	55	13	the	the	DT
cord-297078-pxggjaby	55	14	largest	large	JJS
cord-297078-pxggjaby	55	15	RNA	RNA	NNP
cord-297078-pxggjaby	55	16	viruses	virus	NNS
cord-297078-pxggjaby	55	17	,	,	,
cord-297078-pxggjaby	55	18	the	the	DT
cord-297078-pxggjaby	55	19	single	single	RB
cord-297078-pxggjaby	55	20	-	-	HYPH
cord-297078-pxggjaby	55	21	stranded	strand	VBN
cord-297078-pxggjaby	55	22	coronaviruses	coronaviruse	NNS
cord-297078-pxggjaby	55	23	,	,	,
cord-297078-pxggjaby	55	24	are	be	VBP
cord-297078-pxggjaby	55	25	around	around	RB
cord-297078-pxggjaby	55	26	30	30	CD
cord-297078-pxggjaby	55	27	kb	kb	NNP
cord-297078-pxggjaby	55	28	(	(	-LRB-
cord-297078-pxggjaby	55	29	Atkins	Atkins	NNP
cord-297078-pxggjaby	55	30	1993	1993	CD
cord-297078-pxggjaby	55	31	;	;	:
cord-297078-pxggjaby	55	32	Marra	Marra	NNP
cord-297078-pxggjaby	55	33	et	et	NNP
cord-297078-pxggjaby	55	34	al	al	NNP
cord-297078-pxggjaby	55	35	.	.	NNP
cord-297078-pxggjaby	55	36	2003	2003	CD
cord-297078-pxggjaby	55	37	;	;	:
cord-297078-pxggjaby	55	38	Rota	Rota	NNP
cord-297078-pxggjaby	55	39	et	et	NNP
cord-297078-pxggjaby	55	40	al	al	NNP
cord-297078-pxggjaby	55	41	.	.	NNP
cord-297078-pxggjaby	55	42	2003	2003	CD
cord-297078-pxggjaby	55	43	)	)	-RRB-
cord-297078-pxggjaby	55	44	.	.	.
cord-297078-pxggjaby	56	1	While	while	IN
cord-297078-pxggjaby	56	2	RNA	RNA	NNP
cord-297078-pxggjaby	56	3	virus	virus	NN
cord-297078-pxggjaby	56	4	genomes	genome	NNS
cord-297078-pxggjaby	56	5	are	be	VBP
cord-297078-pxggjaby	56	6	probably	probably	RB
cord-297078-pxggjaby	56	7	under	under	IN
cord-297078-pxggjaby	56	8	selection	selection	NN
cord-297078-pxggjaby	56	9	to	to	TO
cord-297078-pxggjaby	56	10	be	be	VB
cord-297078-pxggjaby	56	11	small	small	JJ
cord-297078-pxggjaby	57	1	(	(	-LRB-
cord-297078-pxggjaby	57	2	Crotty	Crotty	NNP
cord-297078-pxggjaby	57	3	and	and	CC
cord-297078-pxggjaby	57	4	Andino	Andino	NNP
cord-297078-pxggjaby	57	5	2002	2002	CD
cord-297078-pxggjaby	57	6	)	)	-RRB-
cord-297078-pxggjaby	57	7	,	,	,
cord-297078-pxggjaby	57	8	a	a	DT
cord-297078-pxggjaby	57	9	genome	genome	NN
cord-297078-pxggjaby	57	10	of	of	IN
cord-297078-pxggjaby	57	11	30	30	CD
cord-297078-pxggjaby	57	12	kb	kb	NNP
cord-297078-pxggjaby	57	13	causes	cause	VBZ
cord-297078-pxggjaby	57	14	problems	problem	NNS
cord-297078-pxggjaby	57	15	both	both	DT
cord-297078-pxggjaby	57	16	for	for	IN
cord-297078-pxggjaby	57	17	the	the	DT
cord-297078-pxggjaby	57	18	RNA	RNA	NNP
cord-297078-pxggjaby	57	19	world	world	NN
cord-297078-pxggjaby	57	20	and	and	CC
cord-297078-pxggjaby	57	21	for	for	IN
cord-297078-pxggjaby	57	22	an	an	DT
cord-297078-pxggjaby	57	23	RNA	RNA	NNP
cord-297078-pxggjaby	57	24	-	-	HYPH
cord-297078-pxggjaby	57	25	based	base	VBN
cord-297078-pxggjaby	57	26	LUCA	LUCA	NNP
cord-297078-pxggjaby	57	27	.	.	.
cord-297078-pxggjaby	58	1	Partial	partial	JJ
cord-297078-pxggjaby	58	2	reconstructions	reconstruction	NNS
cord-297078-pxggjaby	58	3	of	of	IN
cord-297078-pxggjaby	58	4	the	the	DT
cord-297078-pxggjaby	58	5	late	late	JJ
cord-297078-pxggjaby	58	6	stages	stage	NNS
cord-297078-pxggjaby	58	7	of	of	IN
cord-297078-pxggjaby	58	8	the	the	DT
cord-297078-pxggjaby	58	9	RNP	RNP	NNP
cord-297078-pxggjaby	58	10	world	world	NN
cord-297078-pxggjaby	58	11	Yarus	Yarus	NNP
cord-297078-pxggjaby	58	12	2002	2002	CD
cord-297078-pxggjaby	58	13	)	)	-RRB-
cord-297078-pxggjaby	58	14	appear	appear	VBP
cord-297078-pxggjaby	58	15	to	to	TO
cord-297078-pxggjaby	58	16	overstep	overstep	VB
cord-297078-pxggjaby	58	17	this	this	DT
cord-297078-pxggjaby	58	18	limit	limit	NN
cord-297078-pxggjaby	58	19	,	,	,
cord-297078-pxggjaby	58	20	and	and	CC
cord-297078-pxggjaby	58	21	conservation	conservation	NN
cord-297078-pxggjaby	58	22	of	of	IN
cord-297078-pxggjaby	58	23	the	the	DT
cord-297078-pxggjaby	58	24	ribosomal	ribosomal	JJ
cord-297078-pxggjaby	58	25	protein	protein	NN
cord-297078-pxggjaby	58	26	superoperon	superoperon	NN
cord-297078-pxggjaby	58	27	between	between	IN
cord-297078-pxggjaby	58	28	archaea	archaea	NNS
cord-297078-pxggjaby	58	29	and	and	CC
cord-297078-pxggjaby	58	30	bacteria	bacteria	NNS
cord-297078-pxggjaby	58	31	has	have	VBZ
cord-297078-pxggjaby	58	32	been	be	VBN
cord-297078-pxggjaby	58	33	interpreted	interpret	VBN
cord-297078-pxggjaby	58	34	as	as	IN
cord-297078-pxggjaby	58	35	evidence	evidence	NN
cord-297078-pxggjaby	58	36	for	for	IN
cord-297078-pxggjaby	58	37	genomes	genome	NNS
cord-297078-pxggjaby	58	38	in	in	IN
cord-297078-pxggjaby	58	39	excess	excess	NN
cord-297078-pxggjaby	58	40	of	of	IN
cord-297078-pxggjaby	58	41	30	30	CD
cord-297078-pxggjaby	58	42	kb	kb	NNP
cord-297078-pxggjaby	58	43	in	in	IN
cord-297078-pxggjaby	58	44	LUCA	LUCA	NNP
cord-297078-pxggjaby	59	1	(	(	-LRB-
cord-297078-pxggjaby	59	2	Leipe	Leipe	NNP
cord-297078-pxggjaby	59	3	,	,	,
cord-297078-pxggjaby	59	4	Aravind	Aravind	NNP
cord-297078-pxggjaby	59	5	,	,	,
cord-297078-pxggjaby	59	6	and	and	CC
cord-297078-pxggjaby	59	7	Koonin	Koonin	NNP
cord-297078-pxggjaby	59	8	1999	1999	CD
cord-297078-pxggjaby	59	9	)	)	-RRB-
cord-297078-pxggjaby	59	10	.	.	.
cord-297078-pxggjaby	60	1	Several	several	JJ
cord-297078-pxggjaby	60	2	features	feature	NNS
cord-297078-pxggjaby	60	3	of	of	IN
cord-297078-pxggjaby	60	4	genomes	genome	NNS
cord-297078-pxggjaby	60	5	could	could	MD
cord-297078-pxggjaby	60	6	potentially	potentially	RB
cord-297078-pxggjaby	60	7	increase	increase	VB
cord-297078-pxggjaby	60	8	information	information	NN
cord-297078-pxggjaby	60	9	content	content	NN
cord-297078-pxggjaby	60	10	and	and	CC
cord-297078-pxggjaby	60	11	genome	genome	NN
cord-297078-pxggjaby	60	12	size	size	NN
cord-297078-pxggjaby	60	13	.	.	.
cord-297078-pxggjaby	61	1	These	these	DT
cord-297078-pxggjaby	61	2	include	include	VBP
cord-297078-pxggjaby	61	3	the	the	DT
cord-297078-pxggjaby	61	4	early	early	JJ
cord-297078-pxggjaby	61	5	evolution	evolution	NN
cord-297078-pxggjaby	61	6	of	of	IN
cord-297078-pxggjaby	61	7	recombination	recombination	NN
cord-297078-pxggjaby	61	8	,	,	,
cord-297078-pxggjaby	61	9	redundancy	redundancy	NN
cord-297078-pxggjaby	61	10	through	through	IN
cord-297078-pxggjaby	61	11	polyploidy	polyploidy	NN
cord-297078-pxggjaby	61	12	,	,	,
cord-297078-pxggjaby	61	13	division	division	NN
cord-297078-pxggjaby	61	14	into	into	IN
cord-297078-pxggjaby	61	15	chromosomes	chromosome	NNS
cord-297078-pxggjaby	61	16	,	,	,
cord-297078-pxggjaby	61	17	and	and	CC
cord-297078-pxggjaby	61	18	overlapping	overlapping	JJ
cord-297078-pxggjaby	61	19	sequences	sequence	NNS
cord-297078-pxggjaby	61	20	as	as	IN
cord-297078-pxggjaby	61	21	a	a	DT
cord-297078-pxggjaby	61	22	means	means	NN
cord-297078-pxggjaby	61	23	of	of	IN
cord-297078-pxggjaby	61	24	reducing	reduce	VBG
cord-297078-pxggjaby	61	25	mutational	mutational	JJ
cord-297078-pxggjaby	61	26	targets	target	NNS
cord-297078-pxggjaby	61	27	(	(	-LRB-
cord-297078-pxggjaby	61	28	Reanney	Reanney	NNP
cord-297078-pxggjaby	61	29	1987	1987	CD
cord-297078-pxggjaby	61	30	;	;	:
cord-297078-pxggjaby	61	31	Jeffares	Jeffares	NNP
cord-297078-pxggjaby	61	32	,	,	,
cord-297078-pxggjaby	61	33	Poole	Poole	NNP
cord-297078-pxggjaby	61	34	,	,	,
cord-297078-pxggjaby	61	35	and	and	CC
cord-297078-pxggjaby	61	36	Penny	Penny	NNP
cord-297078-pxggjaby	61	37	1998	1998	CD
cord-297078-pxggjaby	61	38	;	;	:
cord-297078-pxggjaby	61	39	Lehman	Lehman	NNP
cord-297078-pxggjaby	61	40	2003	2003	CD
cord-297078-pxggjaby	61	41	;	;	:
cord-297078-pxggjaby	61	42	Peleg	Peleg	NNP
cord-297078-pxggjaby	61	43	et	et	NNP
cord-297078-pxggjaby	61	44	al	al	NNP
cord-297078-pxggjaby	61	45	.	.	.
cord-297078-pxggjaby	62	1	2004	2004	CD
cord-297078-pxggjaby	62	2	;	;	:
cord-297078-pxggjaby	62	3	Santos	Santos	NNP
cord-297078-pxggjaby	62	4	,	,	,
cord-297078-pxggjaby	62	5	Zintzaras	Zintzaras	NNP
cord-297078-pxggjaby	62	6	,	,	,
cord-297078-pxggjaby	62	7	and	and	CC
cord-297078-pxggjaby	62	8	Szathmáry	Szathmáry	NNP
cord-297078-pxggjaby	62	9	2004	2004	CD
cord-297078-pxggjaby	62	10	)	)	-RRB-
cord-297078-pxggjaby	62	11	.	.	.
cord-297078-pxggjaby	63	1	All	all	PDT
cord-297078-pxggjaby	63	2	these	these	DT
cord-297078-pxggjaby	63	3	mechanisms	mechanism	NNS
cord-297078-pxggjaby	63	4	are	be	VBP
cord-297078-pxggjaby	63	5	available	available	JJ
cord-297078-pxggjaby	63	6	to	to	IN
cord-297078-pxggjaby	63	7	modern	modern	JJ
cord-297078-pxggjaby	63	8	RNA	RNA	NNP
cord-297078-pxggjaby	63	9	viruses	virus	NNS
cord-297078-pxggjaby	63	10	;	;	:
cord-297078-pxggjaby	63	11	yet	yet	CC
cord-297078-pxggjaby	63	12	,	,	,
cord-297078-pxggjaby	63	13	the	the	DT
cord-297078-pxggjaby	63	14	upper	upper	JJ
cord-297078-pxggjaby	63	15	limit	limit	NN
cord-297078-pxggjaby	63	16	of	of	IN
cord-297078-pxggjaby	63	17	;	;	:
cord-297078-pxggjaby	63	18	30	30	CD
cord-297078-pxggjaby	63	19	kb	kb	NNP
cord-297078-pxggjaby	63	20	,	,	,
cord-297078-pxggjaby	63	21	on	on	IN
cord-297078-pxggjaby	63	22	the	the	DT
cord-297078-pxggjaby	63	23	same	same	JJ
cord-297078-pxggjaby	63	24	order	order	NN
cord-297078-pxggjaby	63	25	of	of	IN
cord-297078-pxggjaby	63	26	magnitude	magnitude	NN
cord-297078-pxggjaby	63	27	as	as	IN
cord-297078-pxggjaby	63	28	predicted	predict	VBN
cord-297078-pxggjaby	63	29	by	by	IN
cord-297078-pxggjaby	63	30	RNA	RNA	NNP
cord-297078-pxggjaby	63	31	polymerase	polymerase	NN
cord-297078-pxggjaby	63	32	fidelity	fidelity	NN
cord-297078-pxggjaby	63	33	,	,	,
cord-297078-pxggjaby	63	34	implies	imply	VBZ
cord-297078-pxggjaby	63	35	that	that	IN
cord-297078-pxggjaby	63	36	RNA	RNA	NNP
cord-297078-pxggjaby	63	37	genome	genome	NN
cord-297078-pxggjaby	63	38	size	size	NN
cord-297078-pxggjaby	63	39	is	be	VBZ
cord-297078-pxggjaby	63	40	nevertheless	nevertheless	RB
cord-297078-pxggjaby	63	41	strongly	strongly	RB
cord-297078-pxggjaby	63	42	determined	determine	VBN
cord-297078-pxggjaby	63	43	by	by	IN
cord-297078-pxggjaby	63	44	this	this	DT
cord-297078-pxggjaby	63	45	parameter	parameter	NN
cord-297078-pxggjaby	63	46	.	.	.
cord-297078-pxggjaby	64	1	While	while	IN
cord-297078-pxggjaby	64	2	any	any	DT
cord-297078-pxggjaby	64	3	specific	specific	JJ
cord-297078-pxggjaby	64	4	number	number	NN
cord-297078-pxggjaby	64	5	(	(	-LRB-
cord-297078-pxggjaby	64	6	e.g.	e.g.	RB
cord-297078-pxggjaby	64	7	,	,	,
cord-297078-pxggjaby	64	8	500	500	CD
cord-297078-pxggjaby	64	9	genes	gene	NNS
cord-297078-pxggjaby	64	10	;	;	:
cord-297078-pxggjaby	64	11	Mirkin	Mirkin	NNP
cord-297078-pxggjaby	64	12	et	et	NNP
cord-297078-pxggjaby	64	13	al	al	NNP
cord-297078-pxggjaby	64	14	.	.	NNP
cord-297078-pxggjaby	64	15	2003	2003	CD
cord-297078-pxggjaby	64	16	)	)	-RRB-
cord-297078-pxggjaby	64	17	is	be	VBZ
cord-297078-pxggjaby	64	18	open	open	JJ
cord-297078-pxggjaby	64	19	to	to	IN
cord-297078-pxggjaby	64	20	debate	debate	NN
cord-297078-pxggjaby	64	21	,	,	,
cord-297078-pxggjaby	64	22	the	the	DT
cord-297078-pxggjaby	64	23	numbers	number	NNS
cord-297078-pxggjaby	64	24	give	give	VBP
cord-297078-pxggjaby	64	25	some	some	DT
cord-297078-pxggjaby	64	26	indication	indication	NN
cord-297078-pxggjaby	64	27	of	of	IN
cord-297078-pxggjaby	64	28	the	the	DT
cord-297078-pxggjaby	64	29	coding	coding	NN
cord-297078-pxggjaby	64	30	problem	problem	NN
cord-297078-pxggjaby	64	31	.	.	.
cord-297078-pxggjaby	65	1	For	for	IN
cord-297078-pxggjaby	65	2	instance	instance	NN
cord-297078-pxggjaby	65	3	,	,	,
cord-297078-pxggjaby	65	4	if	if	IN
cord-297078-pxggjaby	65	5	gene	gene	NN
cord-297078-pxggjaby	65	6	size	size	NN
cord-297078-pxggjaby	65	7	in	in	IN
cord-297078-pxggjaby	65	8	LUCA	LUCA	NNP
cord-297078-pxggjaby	65	9	was	be	VBD
cord-297078-pxggjaby	65	10	on	on	IN
cord-297078-pxggjaby	65	11	average	average	JJ
cord-297078-pxggjaby	65	12	half	half	NN
cord-297078-pxggjaby	65	13	that	that	DT
cord-297078-pxggjaby	65	14	of	of	IN
cord-297078-pxggjaby	65	15	modern	modern	JJ
cord-297078-pxggjaby	65	16	bacteria	bacteria	NNS
cord-297078-pxggjaby	65	17	(	(	-LRB-
cord-297078-pxggjaby	65	18	i.e.	i.e.	FW
cord-297078-pxggjaby	65	19	,	,	,
cord-297078-pxggjaby	65	20	;	;	:
cord-297078-pxggjaby	65	21	500	500	CD
cord-297078-pxggjaby	65	22	bp	bp	NNP
cord-297078-pxggjaby	65	23	)	)	-RRB-
cord-297078-pxggjaby	65	24	,	,	,
cord-297078-pxggjaby	65	25	a	a	DT
cord-297078-pxggjaby	65	26	genome	genome	NN
cord-297078-pxggjaby	65	27	with	with	IN
cord-297078-pxggjaby	65	28	500	500	CD
cord-297078-pxggjaby	65	29	genes	gene	NNS
cord-297078-pxggjaby	65	30	would	would	MD
cord-297078-pxggjaby	65	31	be	be	VB
cord-297078-pxggjaby	65	32	Deoxyribonucleotides	Deoxyribonucleotides	NNP
cord-297078-pxggjaby	65	33	could	could	MD
cord-297078-pxggjaby	65	34	have	have	VB
cord-297078-pxggjaby	65	35	been	be	VBN
cord-297078-pxggjaby	65	36	synthesized	synthesize	VBN
cord-297078-pxggjaby	65	37	prebiotically	prebiotically	RB
cord-297078-pxggjaby	65	38	,	,	,
cord-297078-pxggjaby	65	39	and	and	CC
cord-297078-pxggjaby	65	40	with	with	IN
cord-297078-pxggjaby	65	41	the	the	DT
cord-297078-pxggjaby	65	42	discovery	discovery	NN
cord-297078-pxggjaby	65	43	that	that	IN
cord-297078-pxggjaby	65	44	DNA	DNA	NNP
cord-297078-pxggjaby	65	45	can	can	MD
cord-297078-pxggjaby	65	46	be	be	VB
cord-297078-pxggjaby	65	47	made	make	VBN
cord-297078-pxggjaby	65	48	to	to	TO
cord-297078-pxggjaby	65	49	carry	carry	VB
cord-297078-pxggjaby	65	50	out	out	RP
cord-297078-pxggjaby	65	51	catalysis	catalysis	NN
cord-297078-pxggjaby	65	52	,	,	,
cord-297078-pxggjaby	65	53	it	-PRON-	PRP
cord-297078-pxggjaby	65	54	is	be	VBZ
cord-297078-pxggjaby	65	55	not	not	RB
cord-297078-pxggjaby	65	56	impossible	impossible	JJ
cord-297078-pxggjaby	65	57	to	to	TO
cord-297078-pxggjaby	65	58	envision	envision	VB
cord-297078-pxggjaby	65	59	DNA	DNA	NNP
cord-297078-pxggjaby	65	60	emerging	emerge	VBG
cord-297078-pxggjaby	65	61	before	before	IN
cord-297078-pxggjaby	65	62	RNA	RNA	NNP
cord-297078-pxggjaby	65	63	and	and	CC
cord-297078-pxggjaby	65	64	proteins	protein	NNS
cord-297078-pxggjaby	65	65	,	,	,
cord-297078-pxggjaby	65	66	though	though	IN
cord-297078-pxggjaby	65	67	this	this	DT
cord-297078-pxggjaby	65	68	idea	idea	NN
cord-297078-pxggjaby	65	69	is	be	VBZ
cord-297078-pxggjaby	65	70	not	not	RB
cord-297078-pxggjaby	65	71	widely	widely	RB
cord-297078-pxggjaby	65	72	accepted	accept	VBN
cord-297078-pxggjaby	65	73	(	(	-LRB-
cord-297078-pxggjaby	65	74	reviewed	review	VBN
cord-297078-pxggjaby	65	75	in	in	IN
cord-297078-pxggjaby	65	76	Dworkin	Dworkin	NNP
cord-297078-pxggjaby	65	77	,	,	,
cord-297078-pxggjaby	65	78	Lazcano	Lazcano	NNP
cord-297078-pxggjaby	65	79	,	,	,
cord-297078-pxggjaby	65	80	and	and	CC
cord-297078-pxggjaby	65	81	Miller	Miller	NNP
cord-297078-pxggjaby	65	82	[	[	-LRB-
cord-297078-pxggjaby	65	83	2003	2003	CD
cord-297078-pxggjaby	65	84	]	]	-RRB-
cord-297078-pxggjaby	65	85	)	)	-RRB-
cord-297078-pxggjaby	65	86	.	.	.
cord-297078-pxggjaby	66	1	Scenario	scenario	NN
cord-297078-pxggjaby	66	2	2	2	CD
cord-297078-pxggjaby	66	3	:	:	:
cord-297078-pxggjaby	67	1	It	-PRON-	PRP
cord-297078-pxggjaby	67	2	has	have	VBZ
cord-297078-pxggjaby	67	3	been	be	VBN
cord-297078-pxggjaby	67	4	suggested	suggest	VBN
cord-297078-pxggjaby	67	5	that	that	IN
cord-297078-pxggjaby	67	6	deoxyribonucleotide	deoxyribonucleotide	JJ
cord-297078-pxggjaby	67	7	synthesis	synthesis	NN
cord-297078-pxggjaby	67	8	could	could	MD
cord-297078-pxggjaby	67	9	have	have	VB
cord-297078-pxggjaby	67	10	originally	originally	RB
cord-297078-pxggjaby	67	11	occurred	occur	VBN
cord-297078-pxggjaby	67	12	via	via	IN
cord-297078-pxggjaby	67	13	a	a	DT
cord-297078-pxggjaby	67	14	reverse	reverse	NN
cord-297078-pxggjaby	67	15	of	of	IN
cord-297078-pxggjaby	67	16	the	the	DT
cord-297078-pxggjaby	67	17	deoxyriboaldolase	deoxyriboaldolase	NN
cord-297078-pxggjaby	67	18	reaction	reaction	NN
cord-297078-pxggjaby	67	19	.	.	.
cord-297078-pxggjaby	68	1	In	in	IN
cord-297078-pxggjaby	68	2	modern	modern	JJ
cord-297078-pxggjaby	68	3	cells	cell	NNS
cord-297078-pxggjaby	68	4	,	,	,
cord-297078-pxggjaby	68	5	deoxyribose-5-phosphate	deoxyribose-5-phosphate	NNP
cord-297078-pxggjaby	68	6	is	be	VBZ
cord-297078-pxggjaby	68	7	broken	break	VBN
cord-297078-pxggjaby	68	8	down	down	RP
cord-297078-pxggjaby	68	9	to	to	IN
cord-297078-pxggjaby	68	10	glyceraldehyde-3-phosphate	glyceraldehyde-3-phosphate	NNP
cord-297078-pxggjaby	68	11	and	and	CC
cord-297078-pxggjaby	68	12	acetaldehyde	acetaldehyde	NN
cord-297078-pxggjaby	68	13	during	during	IN
cord-297078-pxggjaby	68	14	salvage	salvage	NN
cord-297078-pxggjaby	68	15	.	.	.
cord-297078-pxggjaby	69	1	The	the	DT
cord-297078-pxggjaby	69	2	reverse	reverse	JJ
cord-297078-pxggjaby	69	3	reaction	reaction	NN
cord-297078-pxggjaby	69	4	is	be	VBZ
cord-297078-pxggjaby	69	5	energetically	energetically	RB
cord-297078-pxggjaby	69	6	favorable	favorable	JJ
cord-297078-pxggjaby	69	7	and	and	CC
cord-297078-pxggjaby	69	8	has	have	VBZ
cord-297078-pxggjaby	69	9	been	be	VBN
cord-297078-pxggjaby	69	10	argued	argue	VBN
cord-297078-pxggjaby	69	11	to	to	TO
cord-297078-pxggjaby	69	12	be	be	VB
cord-297078-pxggjaby	69	13	'	'	``
cord-297078-pxggjaby	69	14	'	'	''
cord-297078-pxggjaby	69	15	easier	easy	JJR
cord-297078-pxggjaby	69	16	'	'	''
cord-297078-pxggjaby	69	17	'	'	''
cord-297078-pxggjaby	69	18	to	to	TO
cord-297078-pxggjaby	69	19	evolve	evolve	VB
cord-297078-pxggjaby	69	20	than	than	IN
cord-297078-pxggjaby	69	21	protein	protein	NN
cord-297078-pxggjaby	69	22	synthesis	synthesis	NN
cord-297078-pxggjaby	69	23	(	(	-LRB-
cord-297078-pxggjaby	69	24	Benner	Benner	NNP
cord-297078-pxggjaby	69	25	,	,	,
cord-297078-pxggjaby	69	26	Ellington	Ellington	NNP
cord-297078-pxggjaby	69	27	,	,	,
cord-297078-pxggjaby	69	28	and	and	CC
cord-297078-pxggjaby	69	29	Tauer	Tauer	NNP
cord-297078-pxggjaby	69	30	1989	1989	CD
cord-297078-pxggjaby	69	31	)	)	-RRB-
cord-297078-pxggjaby	69	32	,	,	,
cord-297078-pxggjaby	69	33	although	although	IN
cord-297078-pxggjaby	69	34	it	-PRON-	PRP
cord-297078-pxggjaby	69	35	is	be	VBZ
cord-297078-pxggjaby	69	36	not	not	RB
cord-297078-pxggjaby	69	37	a	a	DT
cord-297078-pxggjaby	69	38	feature	feature	NN
cord-297078-pxggjaby	69	39	of	of	IN
cord-297078-pxggjaby	69	40	modern	modern	JJ
cord-297078-pxggjaby	69	41	metabolism	metabolism	NN
cord-297078-pxggjaby	69	42	.	.	.
cord-297078-pxggjaby	70	1	Scenario	scenario	NN
cord-297078-pxggjaby	70	2	3	3	CD
cord-297078-pxggjaby	70	3	:	:	:
cord-297078-pxggjaby	71	1	In	in	IN
cord-297078-pxggjaby	71	2	modern	modern	JJ
cord-297078-pxggjaby	71	3	cells	cell	NNS
cord-297078-pxggjaby	71	4	,	,	,
cord-297078-pxggjaby	71	5	deoxyribonucleotides	deoxyribonucleotide	NNS
cord-297078-pxggjaby	71	6	are	be	VBP
cord-297078-pxggjaby	71	7	synthesized	synthesize	VBN
cord-297078-pxggjaby	71	8	by	by	IN
cord-297078-pxggjaby	71	9	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	71	10	reductases	reductase	NNS
cord-297078-pxggjaby	71	11	,	,	,
cord-297078-pxggjaby	71	12	which	which	WDT
cord-297078-pxggjaby	71	13	are	be	VBP
cord-297078-pxggjaby	71	14	ubiquitous	ubiquitous	JJ
cord-297078-pxggjaby	71	15	and	and	CC
cord-297078-pxggjaby	71	16	share	share	VB
cord-297078-pxggjaby	71	17	a	a	DT
cord-297078-pxggjaby	71	18	common	common	JJ
cord-297078-pxggjaby	71	19	origin	origin	NN
cord-297078-pxggjaby	71	20	(	(	-LRB-
cord-297078-pxggjaby	71	21	as	as	IN
cord-297078-pxggjaby	71	22	evidenced	evidence	VBN
cord-297078-pxggjaby	71	23	by	by	IN
cord-297078-pxggjaby	71	24	structure	structure	NN
cord-297078-pxggjaby	71	25	and	and	CC
cord-297078-pxggjaby	71	26	conservation	conservation	NN
cord-297078-pxggjaby	71	27	of	of	IN
cord-297078-pxggjaby	71	28	key	key	JJ
cord-297078-pxggjaby	71	29	catalytic	catalytic	JJ
cord-297078-pxggjaby	71	30	residues	residue	NNS
cord-297078-pxggjaby	71	31	)	)	-RRB-
cord-297078-pxggjaby	71	32	,	,	,
cord-297078-pxggjaby	71	33	despite	despite	IN
cord-297078-pxggjaby	71	34	differing	differ	VBG
cord-297078-pxggjaby	71	35	biochemistries	biochemistry	NNS
cord-297078-pxggjaby	71	36	.	.	.
cord-297078-pxggjaby	72	1	This	this	DT
cord-297078-pxggjaby	72	2	has	have	VBZ
cord-297078-pxggjaby	72	3	been	be	VBN
cord-297078-pxggjaby	72	4	taken	take	VBN
cord-297078-pxggjaby	72	5	to	to	TO
cord-297078-pxggjaby	72	6	suggest	suggest	VB
cord-297078-pxggjaby	72	7	that	that	IN
cord-297078-pxggjaby	72	8	the	the	DT
cord-297078-pxggjaby	72	9	LUCA	LUCA	NNP
cord-297078-pxggjaby	72	10	possessed	possess	VBD
cord-297078-pxggjaby	72	11	DNA	DNA	NNP
cord-297078-pxggjaby	72	12	(	(	-LRB-
cord-297078-pxggjaby	72	13	Pode	Pode	NNP
cord-297078-pxggjaby	72	14	,	,	,
cord-297078-pxggjaby	72	15	Penny	Penny	NNP
cord-297078-pxggjaby	72	16	,	,	,
cord-297078-pxggjaby	72	17	and	and	CC
cord-297078-pxggjaby	72	18	Sjöberg	Sjöberg	NNP
cord-297078-pxggjaby	72	19	2000	2000	CD
cord-297078-pxggjaby	72	20	)	)	-RRB-
cord-297078-pxggjaby	72	21	.	.	.
cord-297078-pxggjaby	73	1	Scenario	scenario	NN
cord-297078-pxggjaby	73	2	4	4	CD
cord-297078-pxggjaby	73	3	:	:	:
cord-297078-pxggjaby	74	1	DNA	dna	NN
cord-297078-pxggjaby	74	2	replication	replication	NN
cord-297078-pxggjaby	74	3	seems	seem	VBZ
cord-297078-pxggjaby	74	4	to	to	TO
cord-297078-pxggjaby	74	5	have	have	VB
cord-297078-pxggjaby	74	6	evolved	evolve	VBN
cord-297078-pxggjaby	74	7	twice	twice	RB
cord-297078-pxggjaby	74	8	,	,	,
cord-297078-pxggjaby	74	9	as	as	IN
cord-297078-pxggjaby	74	10	the	the	DT
cord-297078-pxggjaby	74	11	bacterial	bacterial	JJ
cord-297078-pxggjaby	74	12	apparatus	apparatus	NN
cord-297078-pxggjaby	74	13	shares	share	NNS
cord-297078-pxggjaby	74	14	no	no	DT
cord-297078-pxggjaby	74	15	homology	homology	NN
cord-297078-pxggjaby	74	16	with	with	IN
cord-297078-pxggjaby	74	17	the	the	DT
cord-297078-pxggjaby	74	18	archaeal/	archaeal/	CD
cord-297078-pxggjaby	74	19	eukaryotic	eukaryotic	JJ
cord-297078-pxggjaby	74	20	apparatus	apparatus	NN
cord-297078-pxggjaby	74	21	.	.	.
cord-297078-pxggjaby	75	1	It	-PRON-	PRP
cord-297078-pxggjaby	75	2	has	have	VBZ
cord-297078-pxggjaby	75	3	therefore	therefore	RB
cord-297078-pxggjaby	75	4	been	be	VBN
cord-297078-pxggjaby	75	5	suggested	suggest	VBN
cord-297078-pxggjaby	75	6	that	that	IN
cord-297078-pxggjaby	75	7	LUCA	LUCA	NNP
cord-297078-pxggjaby	75	8	possessed	possess	VBD
cord-297078-pxggjaby	75	9	an	an	DT
cord-297078-pxggjaby	75	10	RNA	RNA	NNP
cord-297078-pxggjaby	75	11	genome	genome	NN
cord-297078-pxggjaby	75	12	or	or	CC
cord-297078-pxggjaby	75	13	,	,	,
cord-297078-pxggjaby	75	14	alternatively	alternatively	RB
cord-297078-pxggjaby	75	15	,	,	,
cord-297078-pxggjaby	75	16	a	a	DT
cord-297078-pxggjaby	75	17	composite	composite	JJ
cord-297078-pxggjaby	75	18	RNA	RNA	NNP
cord-297078-pxggjaby	75	19	/	/	SYM
cord-297078-pxggjaby	75	20	DNA	dna	NN
cord-297078-pxggjaby	75	21	genome	genome	NN
cord-297078-pxggjaby	75	22	(	(	-LRB-
cord-297078-pxggjaby	75	23	Leipe	Leipe	NNP
cord-297078-pxggjaby	75	24	,	,	,
cord-297078-pxggjaby	75	25	Aravind	Aravind	NNP
cord-297078-pxggjaby	75	26	,	,	,
cord-297078-pxggjaby	75	27	and	and	CC
cord-297078-pxggjaby	75	28	Koonin	Koonin	NNP
cord-297078-pxggjaby	75	29	1999	1999	CD
cord-297078-pxggjaby	75	30	;	;	:
cord-297078-pxggjaby	75	31	Forterre	Forterre	NNP
cord-297078-pxggjaby	75	32	2002	2002	CD
cord-297078-pxggjaby	75	33	)	)	-RRB-
cord-297078-pxggjaby	75	34	.	.	.
cord-297078-pxggjaby	76	1	;	;	:
cord-297078-pxggjaby	76	2	250	250	CD
cord-297078-pxggjaby	76	3	kb	kb	NNP
cord-297078-pxggjaby	76	4	,	,	,
cord-297078-pxggjaby	76	5	about	about	IN
cord-297078-pxggjaby	76	6	half	half	PDT
cord-297078-pxggjaby	76	7	that	that	DT
cord-297078-pxggjaby	76	8	of	of	IN
cord-297078-pxggjaby	76	9	Mycoplasma	Mycoplasma	NNP
cord-297078-pxggjaby	76	10	genitalium	genitalium	NN
cord-297078-pxggjaby	76	11	.	.	.
cord-297078-pxggjaby	77	1	With	with	IN
cord-297078-pxggjaby	77	2	half	half	PDT
cord-297078-pxggjaby	77	3	the	the	DT
cord-297078-pxggjaby	77	4	number	number	NN
cord-297078-pxggjaby	77	5	of	of	IN
cord-297078-pxggjaby	77	6	genes	gene	NNS
cord-297078-pxggjaby	77	7	,	,	,
cord-297078-pxggjaby	77	8	as	as	IN
cord-297078-pxggjaby	77	9	suggested	suggest	VBN
cord-297078-pxggjaby	77	10	from	from	IN
cord-297078-pxggjaby	77	11	minimal	minimal	JJ
cord-297078-pxggjaby	77	12	gene	gene	NN
cord-297078-pxggjaby	77	13	set	set	VBN
cord-297078-pxggjaby	77	14	studies	study	NNS
cord-297078-pxggjaby	77	15	(	(	-LRB-
cord-297078-pxggjaby	77	16	Mushegian	Mushegian	NNP
cord-297078-pxggjaby	77	17	and	and	CC
cord-297078-pxggjaby	77	18	Koonin	Koonin	NNP
cord-297078-pxggjaby	77	19	1996	1996	CD
cord-297078-pxggjaby	77	20	;	;	:
cord-297078-pxggjaby	77	21	Hutchison	Hutchison	NNP
cord-297078-pxggjaby	77	22	et	et	NNP
cord-297078-pxggjaby	77	23	al	al	NNP
cord-297078-pxggjaby	77	24	.	.	.
cord-297078-pxggjaby	77	25	1999	1999	CD
cord-297078-pxggjaby	77	26	)	)	-RRB-
cord-297078-pxggjaby	77	27	,	,	,
cord-297078-pxggjaby	77	28	the	the	DT
cord-297078-pxggjaby	77	29	genome	genome	NN
cord-297078-pxggjaby	77	30	would	would	MD
cord-297078-pxggjaby	77	31	still	still	RB
cord-297078-pxggjaby	77	32	be	be	VB
cord-297078-pxggjaby	77	33	;	;	:
cord-297078-pxggjaby	77	34	125	125	CD
cord-297078-pxggjaby	77	35	kb	kb	NNS
cord-297078-pxggjaby	77	36	,	,	,
cord-297078-pxggjaby	77	37	well	well	RB
cord-297078-pxggjaby	77	38	above	above	IN
cord-297078-pxggjaby	77	39	the	the	DT
cord-297078-pxggjaby	77	40	size	size	NN
cord-297078-pxggjaby	77	41	of	of	IN
cord-297078-pxggjaby	77	42	the	the	DT
cord-297078-pxggjaby	77	43	largest	large	JJS
cord-297078-pxggjaby	77	44	RNA	RNA	NNP
cord-297078-pxggjaby	77	45	viruses	virus	NNS
cord-297078-pxggjaby	77	46	.	.	.
cord-297078-pxggjaby	78	1	Santos	Santos	NNP
cord-297078-pxggjaby	78	2	,	,	,
cord-297078-pxggjaby	78	3	Zintzaras	Zintzaras	NNP
cord-297078-pxggjaby	78	4	,	,	,
cord-297078-pxggjaby	78	5	and	and	CC
cord-297078-pxggjaby	78	6	Szathmáry	Szathmáry	NNP
cord-297078-pxggjaby	78	7	(	(	-LRB-
cord-297078-pxggjaby	78	8	2004	2004	CD
cord-297078-pxggjaby	78	9	)	)	-RRB-
cord-297078-pxggjaby	78	10	have	have	VBP
cord-297078-pxggjaby	78	11	presented	present	VBN
cord-297078-pxggjaby	78	12	simulations	simulation	NNS
cord-297078-pxggjaby	78	13	examining	examine	VBG
cord-297078-pxggjaby	78	14	the	the	DT
cord-297078-pxggjaby	78	15	interplay	interplay	NN
cord-297078-pxggjaby	78	16	between	between	IN
cord-297078-pxggjaby	78	17	recombination	recombination	NN
cord-297078-pxggjaby	78	18	and	and	CC
cord-297078-pxggjaby	78	19	redundancy	redundancy	NN
cord-297078-pxggjaby	78	20	in	in	IN
cord-297078-pxggjaby	78	21	a	a	DT
cord-297078-pxggjaby	78	22	simple	simple	JJ
cord-297078-pxggjaby	78	23	replicator	replicator	NN
cord-297078-pxggjaby	78	24	system	system	NN
cord-297078-pxggjaby	78	25	.	.	.
cord-297078-pxggjaby	79	1	They	-PRON-	PRP
cord-297078-pxggjaby	79	2	show	show	VBP
cord-297078-pxggjaby	79	3	that	that	IN
cord-297078-pxggjaby	79	4	,	,	,
cord-297078-pxggjaby	79	5	at	at	IN
cord-297078-pxggjaby	79	6	modest	modest	JJ
cord-297078-pxggjaby	79	7	redundancy	redundancy	NN
cord-297078-pxggjaby	79	8	(	(	-LRB-
cord-297078-pxggjaby	79	9	approximately	approximately	RB
cord-297078-pxggjaby	79	10	three	three	CD
cord-297078-pxggjaby	79	11	-	-	HYPH
cord-297078-pxggjaby	79	12	to	to	IN
cord-297078-pxggjaby	79	13	fourfold	fourfold	NN
cord-297078-pxggjaby	79	14	)	)	-RRB-
cord-297078-pxggjaby	79	15	,	,	,
cord-297078-pxggjaby	79	16	a	a	DT
cord-297078-pxggjaby	79	17	recombination	recombination	NN
cord-297078-pxggjaby	79	18	-	-	HYPH
cord-297078-pxggjaby	79	19	competent	competent	JJ
cord-297078-pxggjaby	79	20	system	system	NN
cord-297078-pxggjaby	79	21	could	could	MD
cord-297078-pxggjaby	79	22	increase	increase	VB
cord-297078-pxggjaby	79	23	information	information	NN
cord-297078-pxggjaby	79	24	content	content	NN
cord-297078-pxggjaby	79	25	by	by	IN
cord-297078-pxggjaby	79	26	at	at	RB
cord-297078-pxggjaby	79	27	least	least	RBS
cord-297078-pxggjaby	79	28	25	25	CD
cord-297078-pxggjaby	79	29	%	%	NN
cord-297078-pxggjaby	79	30	,	,	,
cord-297078-pxggjaby	79	31	which	which	WDT
cord-297078-pxggjaby	79	32	the	the	DT
cord-297078-pxggjaby	79	33	authors	author	NNS
cord-297078-pxggjaby	79	34	conclude	conclude	VBP
cord-297078-pxggjaby	79	35	is	be	VBZ
cord-297078-pxggjaby	79	36	nevertheless	nevertheless	RB
cord-297078-pxggjaby	79	37	insufficient	insufficient	JJ
cord-297078-pxggjaby	79	38	for	for	IN
cord-297078-pxggjaby	79	39	emergence	emergence	NN
cord-297078-pxggjaby	79	40	of	of	IN
cord-297078-pxggjaby	79	41	a	a	DT
cord-297078-pxggjaby	79	42	simple	simple	JJ
cord-297078-pxggjaby	79	43	ribozyme	ribozyme	NN
cord-297078-pxggjaby	79	44	replicase	replicase	NN
cord-297078-pxggjaby	79	45	,	,	,
cord-297078-pxggjaby	79	46	let	let	VB
cord-297078-pxggjaby	79	47	alone	alone	RB
cord-297078-pxggjaby	79	48	a	a	DT
cord-297078-pxggjaby	79	49	complex	complex	JJ
cord-297078-pxggjaby	79	50	RNA	RNA	NNP
cord-297078-pxggjaby	79	51	cell	cell	NN
cord-297078-pxggjaby	79	52	,	,	,
cord-297078-pxggjaby	79	53	in	in	IN
cord-297078-pxggjaby	79	54	line	line	NN
cord-297078-pxggjaby	79	55	with	with	IN
cord-297078-pxggjaby	79	56	the	the	DT
cord-297078-pxggjaby	79	57	consensus	consensus	NN
cord-297078-pxggjaby	79	58	that	that	WDT
cord-297078-pxggjaby	79	59	limits	limit	VBZ
cord-297078-pxggjaby	79	60	to	to	IN
cord-297078-pxggjaby	79	61	RNA	rna	NN
cord-297078-pxggjaby	79	62	-	-	HYPH
cord-297078-pxggjaby	79	63	coding	code	VBG
cord-297078-pxggjaby	79	64	capacity	capacity	NN
cord-297078-pxggjaby	79	65	is	be	VBZ
cord-297078-pxggjaby	79	66	a	a	DT
cord-297078-pxggjaby	79	67	major	major	JJ
cord-297078-pxggjaby	79	68	problem	problem	NN
cord-297078-pxggjaby	79	69	in	in	IN
cord-297078-pxggjaby	79	70	the	the	DT
cord-297078-pxggjaby	79	71	evolution	evolution	NN
cord-297078-pxggjaby	79	72	of	of	IN
cord-297078-pxggjaby	79	73	life	life	NN
cord-297078-pxggjaby	79	74	Joyce	Joyce	NNP
cord-297078-pxggjaby	79	75	and	and	CC
cord-297078-pxggjaby	79	76	Orgel	Orgel	NNP
cord-297078-pxggjaby	79	77	1999	1999	CD
cord-297078-pxggjaby	80	1	;	;	:
cord-297078-pxggjaby	80	2	Poole	Poole	NNP
cord-297078-pxggjaby	80	3	,	,	,
cord-297078-pxggjaby	80	4	Jeffares	Jeffares	NNP
cord-297078-pxggjaby	80	5	,	,	,
cord-297078-pxggjaby	80	6	and	and	CC
cord-297078-pxggjaby	80	7	Penny	penny	NN
cord-297078-pxggjaby	80	8	1999	1999	CD
cord-297078-pxggjaby	80	9	;	;	:
cord-297078-pxggjaby	80	10	Scheuring	Scheuring	NNP
cord-297078-pxggjaby	80	11	2000	2000	CD
cord-297078-pxggjaby	80	12	)	)	-RRB-
cord-297078-pxggjaby	80	13	.	.	.
cord-297078-pxggjaby	81	1	Returning	return	VBG
cord-297078-pxggjaby	81	2	to	to	IN
cord-297078-pxggjaby	81	3	the	the	DT
cord-297078-pxggjaby	81	4	RNA	RNA	NNP
cord-297078-pxggjaby	81	5	to	to	IN
cord-297078-pxggjaby	81	6	DNA	dna	NN
cord-297078-pxggjaby	81	7	transition	transition	NN
cord-297078-pxggjaby	81	8	,	,	,
cord-297078-pxggjaby	81	9	there	there	EX
cord-297078-pxggjaby	81	10	are	be	VBP
cord-297078-pxggjaby	81	11	two	two	CD
cord-297078-pxggjaby	81	12	specific	specific	JJ
cord-297078-pxggjaby	81	13	problems	problem	NNS
cord-297078-pxggjaby	81	14	.	.	.
cord-297078-pxggjaby	82	1	On	on	IN
cord-297078-pxggjaby	82	2	one	one	CD
cord-297078-pxggjaby	82	3	hand	hand	NN
cord-297078-pxggjaby	82	4	the	the	DT
cord-297078-pxggjaby	82	5	late	late	JJ
cord-297078-pxggjaby	82	6	stages	stage	NNS
cord-297078-pxggjaby	82	7	of	of	IN
cord-297078-pxggjaby	82	8	the	the	DT
cord-297078-pxggjaby	82	9	RNP	RNP	NNP
cord-297078-pxggjaby	82	10	world	world	NN
cord-297078-pxggjaby	82	11	appear	appear	VBP
cord-297078-pxggjaby	82	12	complex	complex	JJ
cord-297078-pxggjaby	82	13	,	,	,
cord-297078-pxggjaby	82	14	so	so	CC
cord-297078-pxggjaby	82	15	how	how	WRB
cord-297078-pxggjaby	82	16	could	could	MD
cord-297078-pxggjaby	82	17	a	a	DT
cord-297078-pxggjaby	82	18	small	small	JJ
cord-297078-pxggjaby	82	19	RNA	RNA	NNP
cord-297078-pxggjaby	82	20	genome	genome	NN
cord-297078-pxggjaby	82	21	have	have	VBP
cord-297078-pxggjaby	82	22	supported	support	VBN
cord-297078-pxggjaby	82	23	both	both	DT
cord-297078-pxggjaby	82	24	protein	protein	NN
cord-297078-pxggjaby	82	25	synthesis	synthesis	NN
cord-297078-pxggjaby	82	26	and	and	CC
cord-297078-pxggjaby	82	27	have	have	VBP
cord-297078-pxggjaby	82	28	evolved	evolve	VBN
cord-297078-pxggjaby	82	29	enzymes	enzyme	NNS
cord-297078-pxggjaby	82	30	as	as	RB
cord-297078-pxggjaby	82	31	chemically	chemically	RB
cord-297078-pxggjaby	82	32	'	'	''
cord-297078-pxggjaby	82	33	'	'	``
cord-297078-pxggjaby	82	34	sophisticated	sophisticated	JJ
cord-297078-pxggjaby	82	35	'	'	''
cord-297078-pxggjaby	82	36	'	'	''
cord-297078-pxggjaby	82	37	as	as	IN
cord-297078-pxggjaby	82	38	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	82	39	reductases	reductases	NNP
cord-297078-pxggjaby	82	40	(	(	-LRB-
cord-297078-pxggjaby	82	41	Poole	Poole	NNP
cord-297078-pxggjaby	82	42	,	,	,
cord-297078-pxggjaby	82	43	Penny	Penny	NNP
cord-297078-pxggjaby	82	44	,	,	,
cord-297078-pxggjaby	82	45	and	and	CC
cord-297078-pxggjaby	82	46	Sjöberg	Sjöberg	NNP
cord-297078-pxggjaby	82	47	2000	2000	CD
cord-297078-pxggjaby	82	48	)	)	-RRB-
cord-297078-pxggjaby	82	49	?	?	.
cord-297078-pxggjaby	83	1	On	on	IN
cord-297078-pxggjaby	83	2	the	the	DT
cord-297078-pxggjaby	83	3	other	other	JJ
cord-297078-pxggjaby	83	4	hand	hand	NN
cord-297078-pxggjaby	83	5	,	,	,
cord-297078-pxggjaby	83	6	how	how	WRB
cord-297078-pxggjaby	83	7	feasible	feasible	JJ
cord-297078-pxggjaby	83	8	is	be	VBZ
cord-297078-pxggjaby	83	9	the	the	DT
cord-297078-pxggjaby	83	10	contention	contention	NN
cord-297078-pxggjaby	83	11	that	that	IN
cord-297078-pxggjaby	83	12	the	the	DT
cord-297078-pxggjaby	83	13	LUCA	LUCA	NNP
cord-297078-pxggjaby	83	14	had	have	VBD
cord-297078-pxggjaby	83	15	an	an	DT
cord-297078-pxggjaby	83	16	RNA	RNA	NNP
cord-297078-pxggjaby	83	17	genome	genome	NN
cord-297078-pxggjaby	83	18	?	?	.
cord-297078-pxggjaby	84	1	This	this	DT
cord-297078-pxggjaby	84	2	second	second	JJ
cord-297078-pxggjaby	84	3	question	question	NN
cord-297078-pxggjaby	84	4	links	link	VBZ
cord-297078-pxggjaby	84	5	LUCA	LUCA	NNP
cord-297078-pxggjaby	84	6	to	to	IN
cord-297078-pxggjaby	84	7	earlier	early	JJR
cord-297078-pxggjaby	84	8	stages	stage	NNS
cord-297078-pxggjaby	84	9	,	,	,
cord-297078-pxggjaby	84	10	namely	namely	RB
cord-297078-pxggjaby	84	11	the	the	DT
cord-297078-pxggjaby	84	12	RNP	RNP	NNP
cord-297078-pxggjaby	84	13	to	to	IN
cord-297078-pxggjaby	84	14	DNA	dna	NN
cord-297078-pxggjaby	84	15	transition	transition	NN
cord-297078-pxggjaby	84	16	,	,	,
cord-297078-pxggjaby	84	17	since	since	IN
cord-297078-pxggjaby	84	18	comparative	comparative	JJ
cord-297078-pxggjaby	84	19	genomics	genomic	NNS
cord-297078-pxggjaby	84	20	data	datum	NNS
cord-297078-pxggjaby	84	21	point	point	NN
cord-297078-pxggjaby	84	22	to	to	IN
cord-297078-pxggjaby	84	23	the	the	DT
cord-297078-pxggjaby	84	24	possibility	possibility	NN
cord-297078-pxggjaby	84	25	of	of	IN
cord-297078-pxggjaby	84	26	DNA	dna	NN
cord-297078-pxggjaby	84	27	replication	replication	NN
cord-297078-pxggjaby	84	28	evolving	evolve	VBG
cord-297078-pxggjaby	84	29	twice	twice	RB
cord-297078-pxggjaby	84	30	,	,	,
cord-297078-pxggjaby	84	31	post	post	VB
cord-297078-pxggjaby	84	32	-	-	NN
cord-297078-pxggjaby	84	33	LUCA	LUCA	NNP
cord-297078-pxggjaby	84	34	.	.	.
cord-297078-pxggjaby	85	1	Given	give	VBN
cord-297078-pxggjaby	85	2	the	the	DT
cord-297078-pxggjaby	85	3	difficulty	difficulty	NN
cord-297078-pxggjaby	85	4	with	with	IN
cord-297078-pxggjaby	85	5	RNA	RNA	NNP
cord-297078-pxggjaby	85	6	as	as	IN
cord-297078-pxggjaby	85	7	genetic	genetic	JJ
cord-297078-pxggjaby	85	8	material	material	NN
cord-297078-pxggjaby	85	9	,	,	,
cord-297078-pxggjaby	85	10	one	one	CD
cord-297078-pxggjaby	85	11	is	be	VBZ
cord-297078-pxggjaby	85	12	almost	almost	RB
cord-297078-pxggjaby	85	13	forced	force	VBN
cord-297078-pxggjaby	85	14	to	to	TO
cord-297078-pxggjaby	85	15	accept	accept	VB
cord-297078-pxggjaby	85	16	Scenario	Scenario	NNP
cord-297078-pxggjaby	85	17	3	3	CD
cord-297078-pxggjaby	85	18	in	in	IN
cord-297078-pxggjaby	85	19	figure	figure	NN
cord-297078-pxggjaby	85	20	1	1	CD
cord-297078-pxggjaby	85	21	over	over	IN
cord-297078-pxggjaby	85	22	Scenario	scenario	NN
cord-297078-pxggjaby	85	23	4	4	CD
cord-297078-pxggjaby	85	24	and	and	CC
cord-297078-pxggjaby	85	25	conclude	conclude	VB
cord-297078-pxggjaby	85	26	that	that	IN
cord-297078-pxggjaby	85	27	there	there	EX
cord-297078-pxggjaby	85	28	was	be	VBD
cord-297078-pxggjaby	85	29	an	an	DT
cord-297078-pxggjaby	85	30	NOGD	NOGD	NNP
cord-297078-pxggjaby	85	31	of	of	IN
cord-297078-pxggjaby	85	32	the	the	DT
cord-297078-pxggjaby	85	33	replication	replication	NN
cord-297078-pxggjaby	85	34	apparatus	apparatus	NN
cord-297078-pxggjaby	85	35	.	.	.
cord-297078-pxggjaby	86	1	However	however	RB
cord-297078-pxggjaby	86	2	,	,	,
cord-297078-pxggjaby	86	3	it	-PRON-	PRP
cord-297078-pxggjaby	86	4	is	be	VBZ
cord-297078-pxggjaby	86	5	now	now	RB
cord-297078-pxggjaby	86	6	becoming	become	VBG
cord-297078-pxggjaby	86	7	apparent	apparent	JJ
cord-297078-pxggjaby	86	8	that	that	IN
cord-297078-pxggjaby	86	9	RNAs	rna	NNS
cord-297078-pxggjaby	86	10	are	be	VBP
cord-297078-pxggjaby	86	11	subject	subject	JJ
cord-297078-pxggjaby	86	12	to	to	IN
cord-297078-pxggjaby	86	13	both	both	DT
cord-297078-pxggjaby	86	14	proofreading	proofreading	NN
cord-297078-pxggjaby	86	15	and	and	CC
cord-297078-pxggjaby	86	16	repair	repair	NN
cord-297078-pxggjaby	87	1	(	(	-LRB-
cord-297078-pxggjaby	87	2	Thomas	Thomas	NNP
cord-297078-pxggjaby	87	3	,	,	,
cord-297078-pxggjaby	87	4	Platas	Platas	NNP
cord-297078-pxggjaby	87	5	,	,	,
cord-297078-pxggjaby	87	6	and	and	CC
cord-297078-pxggjaby	87	7	Hawley	Hawley	NNP
cord-297078-pxggjaby	87	8	1998	1998	CD
cord-297078-pxggjaby	87	9	;	;	:
cord-297078-pxggjaby	87	10	Reichert	Reichert	NNP
cord-297078-pxggjaby	87	11	and	and	CC
cord-297078-pxggjaby	87	12	Mörl	Mörl	NNP
cord-297078-pxggjaby	87	13	2000	2000	CD
cord-297078-pxggjaby	87	14	;	;	:
cord-297078-pxggjaby	87	15	Aas	Aas	NNP
cord-297078-pxggjaby	87	16	et	et	NNP
cord-297078-pxggjaby	87	17	al	al	NNP
cord-297078-pxggjaby	87	18	.	.	NNP
cord-297078-pxggjaby	87	19	2003	2003	CD
cord-297078-pxggjaby	87	20	)	)	-RRB-
cord-297078-pxggjaby	87	21	,	,	,
cord-297078-pxggjaby	87	22	raising	raise	VBG
cord-297078-pxggjaby	87	23	the	the	DT
cord-297078-pxggjaby	87	24	possibility	possibility	NN
cord-297078-pxggjaby	87	25	that	that	IN
cord-297078-pxggjaby	87	26	a	a	DT
cord-297078-pxggjaby	87	27	large	large	JJ
cord-297078-pxggjaby	87	28	genome	genome	NN
cord-297078-pxggjaby	87	29	was	be	VBD
cord-297078-pxggjaby	87	30	possible	possible	JJ
cord-297078-pxggjaby	87	31	in	in	IN
cord-297078-pxggjaby	87	32	the	the	DT
cord-297078-pxggjaby	87	33	absence	absence	NN
cord-297078-pxggjaby	87	34	of	of	IN
cord-297078-pxggjaby	87	35	DNA	dna	NN
cord-297078-pxggjaby	87	36	.	.	.
cord-297078-pxggjaby	88	1	There	there	EX
cord-297078-pxggjaby	88	2	are	be	VBP
cord-297078-pxggjaby	88	3	two	two	CD
cord-297078-pxggjaby	88	4	forms	form	NNS
cord-297078-pxggjaby	88	5	of	of	IN
cord-297078-pxggjaby	88	6	bona	bona	FW
cord-297078-pxggjaby	88	7	fide	fide	FW
cord-297078-pxggjaby	88	8	RNA	RNA	NNP
cord-297078-pxggjaby	88	9	repair	repair	NN
cord-297078-pxggjaby	88	10	now	now	RB
cord-297078-pxggjaby	88	11	known	know	VBN
cord-297078-pxggjaby	88	12	.	.	.
cord-297078-pxggjaby	89	1	One	one	CD
cord-297078-pxggjaby	89	2	is	be	VBZ
cord-297078-pxggjaby	89	3	repair	repair	NN
cord-297078-pxggjaby	89	4	of	of	IN
cord-297078-pxggjaby	89	5	methyl	methyl	NN
cord-297078-pxggjaby	89	6	damage	damage	NN
cord-297078-pxggjaby	89	7	,	,	,
cord-297078-pxggjaby	89	8	conserved	conserve	VBN
cord-297078-pxggjaby	89	9	between	between	IN
cord-297078-pxggjaby	89	10	eukaryotes	eukaryote	NNS
cord-297078-pxggjaby	89	11	and	and	CC
cord-297078-pxggjaby	89	12	bacteria	bacteria	NNS
cord-297078-pxggjaby	89	13	(	(	-LRB-
cord-297078-pxggjaby	89	14	Aas	Aas	NNP
cord-297078-pxggjaby	89	15	et	et	FW
cord-297078-pxggjaby	89	16	al	al	NNP
cord-297078-pxggjaby	89	17	.	.	NNP
cord-297078-pxggjaby	89	18	2003	2003	CD
cord-297078-pxggjaby	89	19	;	;	:
cord-297078-pxggjaby	89	20	Ougland	Ougland	NNP
cord-297078-pxggjaby	89	21	et	et	NNP
cord-297078-pxggjaby	89	22	al	al	NNP
cord-297078-pxggjaby	89	23	.	.	.
cord-297078-pxggjaby	90	1	2004	2004	CD
cord-297078-pxggjaby	90	2	)	)	-RRB-
cord-297078-pxggjaby	91	1	(	(	-LRB-
cord-297078-pxggjaby	91	2	Appendix	Appendix	NNP
cord-297078-pxggjaby	91	3	1	1	CD
cord-297078-pxggjaby	91	4	)	)	-RRB-
cord-297078-pxggjaby	91	5	.	.	.
cord-297078-pxggjaby	92	1	The	the	DT
cord-297078-pxggjaby	92	2	second	second	JJ
cord-297078-pxggjaby	92	3	form	form	NN
cord-297078-pxggjaby	92	4	involves	involve	VBZ
cord-297078-pxggjaby	92	5	proofreading	proofreading	NN
cord-297078-pxggjaby	92	6	and	and	CC
cord-297078-pxggjaby	92	7	repair	repair	NN
cord-297078-pxggjaby	92	8	by	by	IN
cord-297078-pxggjaby	92	9	RNA	RNA	NNP
cord-297078-pxggjaby	92	10	polymerases	polymerase	NNS
cord-297078-pxggjaby	92	11	,	,	,
cord-297078-pxggjaby	92	12	analogous	analogous	JJ
cord-297078-pxggjaby	92	13	to	to	IN
cord-297078-pxggjaby	92	14	that	that	DT
cord-297078-pxggjaby	92	15	observed	observe	VBN
cord-297078-pxggjaby	92	16	with	with	IN
cord-297078-pxggjaby	92	17	DNA	dna	NN
cord-297078-pxggjaby	92	18	polymerases	polymerase	NNS
cord-297078-pxggjaby	92	19	,	,	,
cord-297078-pxggjaby	92	20	and	and	CC
cord-297078-pxggjaby	92	21	is	be	VBZ
cord-297078-pxggjaby	92	22	conserved	conserve	VBN
cord-297078-pxggjaby	92	23	across	across	IN
cord-297078-pxggjaby	92	24	all	all	DT
cord-297078-pxggjaby	92	25	three	three	CD
cord-297078-pxggjaby	92	26	domains	domain	NNS
cord-297078-pxggjaby	92	27	of	of	IN
cord-297078-pxggjaby	92	28	life	life	NN
cord-297078-pxggjaby	92	29	(	(	-LRB-
cord-297078-pxggjaby	92	30	table	table	NN
cord-297078-pxggjaby	92	31	1	1	CD
cord-297078-pxggjaby	92	32	)	)	-RRB-
cord-297078-pxggjaby	92	33	.	.	.
cord-297078-pxggjaby	93	1	We	-PRON-	PRP
cord-297078-pxggjaby	93	2	argue	argue	VBP
cord-297078-pxggjaby	93	3	from	from	IN
cord-297078-pxggjaby	93	4	structural	structural	JJ
cord-297078-pxggjaby	93	5	and	and	CC
cord-297078-pxggjaby	93	6	functional	functional	JJ
cord-297078-pxggjaby	93	7	data	datum	NNS
cord-297078-pxggjaby	93	8	that	that	WDT
cord-297078-pxggjaby	93	9	the	the	DT
cord-297078-pxggjaby	93	10	second	second	JJ
cord-297078-pxggjaby	93	11	of	of	IN
cord-297078-pxggjaby	93	12	these	these	DT
cord-297078-pxggjaby	93	13	,	,	,
cord-297078-pxggjaby	93	14	RNA	RNA	NNP
cord-297078-pxggjaby	93	15	polymerase	polymerase	NN
cord-297078-pxggjaby	93	16	-	-	HYPH
cord-297078-pxggjaby	93	17	dependent	dependent	JJ
cord-297078-pxggjaby	93	18	proofreading	proofreading	NN
cord-297078-pxggjaby	93	19	and	and	CC
cord-297078-pxggjaby	93	20	repair	repair	NN
cord-297078-pxggjaby	93	21	,	,	,
cord-297078-pxggjaby	93	22	is	be	VBZ
cord-297078-pxggjaby	93	23	likely	likely	JJ
cord-297078-pxggjaby	93	24	to	to	TO
cord-297078-pxggjaby	93	25	have	have	VB
cord-297078-pxggjaby	93	26	been	be	VBN
cord-297078-pxggjaby	93	27	a	a	DT
cord-297078-pxggjaby	93	28	feature	feature	NN
cord-297078-pxggjaby	93	29	of	of	IN
cord-297078-pxggjaby	93	30	LUCA	LUCA	NNP
cord-297078-pxggjaby	93	31	rather	rather	RB
cord-297078-pxggjaby	93	32	than	than	IN
cord-297078-pxggjaby	93	33	a	a	DT
cord-297078-pxggjaby	93	34	recent	recent	JJ
cord-297078-pxggjaby	93	35	innovation	innovation	NN
cord-297078-pxggjaby	93	36	as	as	IN
cord-297078-pxggjaby	93	37	part	part	NN
cord-297078-pxggjaby	93	38	of	of	IN
cord-297078-pxggjaby	93	39	selection	selection	NN
cord-297078-pxggjaby	93	40	for	for	IN
cord-297078-pxggjaby	93	41	improved	improved	JJ
cord-297078-pxggjaby	93	42	messenger	messenger	NN
cord-297078-pxggjaby	93	43	RNA	RNA	NNP
cord-297078-pxggjaby	93	44	(	(	-LRB-
cord-297078-pxggjaby	93	45	mRNA	mRNA	NNP
cord-297078-pxggjaby	93	46	)	)	-RRB-
cord-297078-pxggjaby	93	47	quality	quality	NN
cord-297078-pxggjaby	93	48	control	control	NN
cord-297078-pxggjaby	93	49	,	,	,
cord-297078-pxggjaby	93	50	though	though	IN
cord-297078-pxggjaby	93	51	this	this	DT
cord-297078-pxggjaby	93	52	is	be	VBZ
cord-297078-pxggjaby	93	53	no	no	DT
cord-297078-pxggjaby	93	54	doubt	doubt	RB
cord-297078-pxggjaby	93	55	the	the	DT
cord-297078-pxggjaby	93	56	current	current	JJ
cord-297078-pxggjaby	93	57	function	function	NN
cord-297078-pxggjaby	93	58	of	of	IN
cord-297078-pxggjaby	93	59	this	this	DT
cord-297078-pxggjaby	93	60	phenomenon	phenomenon	NN
cord-297078-pxggjaby	93	61	.	.	.
cord-297078-pxggjaby	94	1	We	-PRON-	PRP
cord-297078-pxggjaby	94	2	will	will	MD
cord-297078-pxggjaby	94	3	briefly	briefly	RB
cord-297078-pxggjaby	94	4	summarize	summarize	VB
cord-297078-pxggjaby	94	5	the	the	DT
cord-297078-pxggjaby	94	6	experimental	experimental	JJ
cord-297078-pxggjaby	94	7	evidence	evidence	NN
cord-297078-pxggjaby	94	8	for	for	IN
cord-297078-pxggjaby	94	9	RNA	RNA	NNP
cord-297078-pxggjaby	94	10	repair	repair	NN
cord-297078-pxggjaby	94	11	by	by	IN
cord-297078-pxggjaby	94	12	RNA	RNA	NNP
cord-297078-pxggjaby	94	13	polymerases	polymerase	NNS
cord-297078-pxggjaby	94	14	,	,	,
cord-297078-pxggjaby	94	15	then	then	RB
cord-297078-pxggjaby	94	16	consider	consider	VB
cord-297078-pxggjaby	94	17	the	the	DT
cord-297078-pxggjaby	94	18	implications	implication	NNS
cord-297078-pxggjaby	94	19	for	for	IN
cord-297078-pxggjaby	94	20	the	the	DT
cord-297078-pxggjaby	94	21	RNA	RNA	NNP
cord-297078-pxggjaby	94	22	to	to	IN
cord-297078-pxggjaby	94	23	DNA	dna	NN
cord-297078-pxggjaby	94	24	transition	transition	NN
cord-297078-pxggjaby	94	25	and	and	CC
cord-297078-pxggjaby	94	26	the	the	DT
cord-297078-pxggjaby	94	27	nature	nature	NN
cord-297078-pxggjaby	94	28	of	of	IN
cord-297078-pxggjaby	94	29	the	the	DT
cord-297078-pxggjaby	94	30	genome	genome	NN
cord-297078-pxggjaby	94	31	of	of	IN
cord-297078-pxggjaby	94	32	LUCA	LUCA	NNP
cord-297078-pxggjaby	94	33	.	.	.
cord-297078-pxggjaby	95	1	As	as	IN
cord-297078-pxggjaby	95	2	with	with	IN
cord-297078-pxggjaby	95	3	DNA	DNA	NNP
cord-297078-pxggjaby	95	4	,	,	,
cord-297078-pxggjaby	95	5	RNA	RNA	NNP
cord-297078-pxggjaby	95	6	can	can	MD
cord-297078-pxggjaby	95	7	be	be	VB
cord-297078-pxggjaby	95	8	damaged	damage	VBN
cord-297078-pxggjaby	95	9	as	as	RB
cord-297078-pxggjaby	95	10	well	well	RB
cord-297078-pxggjaby	95	11	as	as	IN
cord-297078-pxggjaby	95	12	incorrectly	incorrectly	RB
cord-297078-pxggjaby	95	13	copied	copy	VBN
cord-297078-pxggjaby	95	14	.	.	.
cord-297078-pxggjaby	96	1	How	how	WRB
cord-297078-pxggjaby	96	2	the	the	DT
cord-297078-pxggjaby	96	3	cell	cell	NN
cord-297078-pxggjaby	96	4	checks	check	VBZ
cord-297078-pxggjaby	96	5	that	that	WDT
cord-297078-pxggjaby	96	6	an	an	DT
cord-297078-pxggjaby	96	7	mRNA	mrna	NN
cord-297078-pxggjaby	96	8	is	be	VBZ
cord-297078-pxggjaby	96	9	correctly	correctly	RB
cord-297078-pxggjaby	96	10	synthesized	synthesize	VBN
cord-297078-pxggjaby	96	11	and	and	CC
cord-297078-pxggjaby	96	12	deals	deal	NNS
cord-297078-pxggjaby	96	13	with	with	IN
cord-297078-pxggjaby	96	14	incorrectly	incorrectly	RB
cord-297078-pxggjaby	96	15	copied	copy	VBN
cord-297078-pxggjaby	96	16	RNAs	rna	NNS
cord-297078-pxggjaby	96	17	is	be	VBZ
cord-297078-pxggjaby	96	18	a	a	DT
cord-297078-pxggjaby	96	19	subject	subject	NN
cord-297078-pxggjaby	96	20	of	of	IN
cord-297078-pxggjaby	96	21	intense	intense	JJ
cord-297078-pxggjaby	96	22	investigation	investigation	NN
cord-297078-pxggjaby	96	23	,	,	,
cord-297078-pxggjaby	96	24	falling	fall	VBG
cord-297078-pxggjaby	96	25	under	under	IN
cord-297078-pxggjaby	96	26	the	the	DT
cord-297078-pxggjaby	96	27	broad	broad	JJ
cord-297078-pxggjaby	96	28	term	term	NN
cord-297078-pxggjaby	96	29	of	of	IN
cord-297078-pxggjaby	96	30	quality	quality	NN
cord-297078-pxggjaby	96	31	control	control	NN
cord-297078-pxggjaby	96	32	.	.	.
cord-297078-pxggjaby	97	1	In	in	IN
cord-297078-pxggjaby	97	2	both	both	DT
cord-297078-pxggjaby	97	3	eukaryotes	eukaryote	NNS
cord-297078-pxggjaby	97	4	and	and	CC
cord-297078-pxggjaby	97	5	bacteria	bacteria	NNS
cord-297078-pxggjaby	97	6	,	,	,
cord-297078-pxggjaby	97	7	there	there	EX
cord-297078-pxggjaby	97	8	are	be	VBP
cord-297078-pxggjaby	97	9	mechanisms	mechanism	NNS
cord-297078-pxggjaby	97	10	for	for	IN
cord-297078-pxggjaby	97	11	eliminating	eliminate	VBG
cord-297078-pxggjaby	97	12	transcripts	transcript	NNS
cord-297078-pxggjaby	97	13	that	that	WDT
cord-297078-pxggjaby	97	14	fail	fail	VBP
cord-297078-pxggjaby	97	15	to	to	TO
cord-297078-pxggjaby	97	16	pass	pass	VB
cord-297078-pxggjaby	97	17	quality	quality	NN
cord-297078-pxggjaby	97	18	control	control	NN
cord-297078-pxggjaby	97	19	(	(	-LRB-
cord-297078-pxggjaby	97	20	Gillet	Gillet	NNP
cord-297078-pxggjaby	97	21	and	and	CC
cord-297078-pxggjaby	97	22	Felden	Felden	NNP
cord-297078-pxggjaby	97	23	2001	2001	CD
cord-297078-pxggjaby	97	24	;	;	:
cord-297078-pxggjaby	97	25	Wilusz	Wilusz	NNP
cord-297078-pxggjaby	97	26	,	,	,
cord-297078-pxggjaby	97	27	Wang	Wang	NNP
cord-297078-pxggjaby	97	28	,	,	,
cord-297078-pxggjaby	97	29	and	and	CC
cord-297078-pxggjaby	97	30	Peltz	Peltz	NNP
cord-297078-pxggjaby	97	31	2001	2001	CD
cord-297078-pxggjaby	97	32	;	;	:
cord-297078-pxggjaby	97	33	Vasudevan	Vasudevan	NNP
cord-297078-pxggjaby	97	34	,	,	,
cord-297078-pxggjaby	97	35	Peltz	Peltz	NNP
cord-297078-pxggjaby	97	36	,	,	,
cord-297078-pxggjaby	97	37	and	and	CC
cord-297078-pxggjaby	97	38	Wilusz	Wilusz	NNP
cord-297078-pxggjaby	97	39	2002	2002	CD
cord-297078-pxggjaby	97	40	)	)	-RRB-
cord-297078-pxggjaby	97	41	.	.	.
cord-297078-pxggjaby	98	1	The	the	DT
cord-297078-pxggjaby	98	2	general	general	JJ
cord-297078-pxggjaby	98	3	expectation	expectation	NN
cord-297078-pxggjaby	98	4	has	have	VBZ
cord-297078-pxggjaby	98	5	been	be	VBN
cord-297078-pxggjaby	98	6	that	that	IN
cord-297078-pxggjaby	98	7	,	,	,
cord-297078-pxggjaby	98	8	following	follow	VBG
cord-297078-pxggjaby	98	9	recognition	recognition	NN
cord-297078-pxggjaby	98	10	of	of	IN
cord-297078-pxggjaby	98	11	a	a	DT
cord-297078-pxggjaby	98	12	damaged	damage	VBN
cord-297078-pxggjaby	98	13	or	or	CC
cord-297078-pxggjaby	98	14	incorrectly	incorrectly	RB
cord-297078-pxggjaby	98	15	synthesized	synthesize	VBN
cord-297078-pxggjaby	98	16	mRNA	mrna	NN
cord-297078-pxggjaby	98	17	,	,	,
cord-297078-pxggjaby	98	18	the	the	DT
cord-297078-pxggjaby	98	19	damaged	damage	VBN
cord-297078-pxggjaby	98	20	molecule	molecule	NN
cord-297078-pxggjaby	98	21	would	would	MD
cord-297078-pxggjaby	98	22	be	be	VB
cord-297078-pxggjaby	98	23	destroyed	destroy	VBN
cord-297078-pxggjaby	98	24	rather	rather	RB
cord-297078-pxggjaby	98	25	than	than	IN
cord-297078-pxggjaby	98	26	repaired	repair	VBN
cord-297078-pxggjaby	98	27	;	;	:
cord-297078-pxggjaby	98	28	repair	repair	NN
cord-297078-pxggjaby	98	29	would	would	MD
cord-297078-pxggjaby	98	30	not	not	RB
cord-297078-pxggjaby	98	31	pay	pay	VB
cord-297078-pxggjaby	98	32	its	-PRON-	PRP$
cord-297078-pxggjaby	98	33	way	way	NN
cord-297078-pxggjaby	98	34	,	,	,
cord-297078-pxggjaby	98	35	since	since	IN
cord-297078-pxggjaby	98	36	thousands	thousand	NNS
cord-297078-pxggjaby	98	37	of	of	IN
cord-297078-pxggjaby	98	38	RNAs	rna	NNS
cord-297078-pxggjaby	98	39	are	be	VBP
cord-297078-pxggjaby	98	40	produced	produce	VBN
cord-297078-pxggjaby	98	41	in	in	IN
cord-297078-pxggjaby	98	42	the	the	DT
cord-297078-pxggjaby	98	43	cell	cell	NN
cord-297078-pxggjaby	98	44	,	,	,
cord-297078-pxggjaby	98	45	and	and	CC
cord-297078-pxggjaby	98	46	therefore	therefore	RB
cord-297078-pxggjaby	98	47	the	the	DT
cord-297078-pxggjaby	98	48	best	good	JJS
cord-297078-pxggjaby	98	49	way	way	NN
cord-297078-pxggjaby	98	50	to	to	TO
cord-297078-pxggjaby	98	51	deal	deal	VB
cord-297078-pxggjaby	98	52	with	with	IN
cord-297078-pxggjaby	98	53	the	the	DT
cord-297078-pxggjaby	98	54	odd	odd	JJ
cord-297078-pxggjaby	98	55	damaged	damage	VBN
cord-297078-pxggjaby	98	56	RNA	RNA	NNP
cord-297078-pxggjaby	98	57	is	be	VBZ
cord-297078-pxggjaby	98	58	to	to	TO
cord-297078-pxggjaby	98	59	break	break	VB
cord-297078-pxggjaby	98	60	it	-PRON-	PRP
cord-297078-pxggjaby	98	61	down	down	RP
cord-297078-pxggjaby	98	62	and	and	CC
cord-297078-pxggjaby	98	63	start	start	VB
cord-297078-pxggjaby	98	64	afresh	afresh	RB
cord-297078-pxggjaby	98	65	.	.	.
cord-297078-pxggjaby	99	1	However	however	RB
cord-297078-pxggjaby	99	2	,	,	,
cord-297078-pxggjaby	99	3	errors	error	NNS
cord-297078-pxggjaby	99	4	in	in	IN
cord-297078-pxggjaby	99	5	transcription	transcription	NN
cord-297078-pxggjaby	99	6	may	may	MD
cord-297078-pxggjaby	99	7	be	be	VB
cord-297078-pxggjaby	99	8	more	more	RBR
cord-297078-pxggjaby	99	9	common	common	JJ
cord-297078-pxggjaby	99	10	than	than	IN
cord-297078-pxggjaby	99	11	the	the	DT
cord-297078-pxggjaby	99	12	above	above	JJ
cord-297078-pxggjaby	99	13	reasoning	reasoning	NN
cord-297078-pxggjaby	99	14	might	may	MD
cord-297078-pxggjaby	99	15	lead	lead	VB
cord-297078-pxggjaby	99	16	us	-PRON-	PRP
cord-297078-pxggjaby	99	17	to	to	TO
cord-297078-pxggjaby	99	18	suppose	suppose	VB
cord-297078-pxggjaby	99	19	.	.	.
cord-297078-pxggjaby	100	1	The	the	DT
cord-297078-pxggjaby	100	2	average	average	JJ
cord-297078-pxggjaby	100	3	length	length	NN
cord-297078-pxggjaby	100	4	of	of	IN
cord-297078-pxggjaby	100	5	proteins	protein	NNS
cord-297078-pxggjaby	100	6	in	in	IN
cord-297078-pxggjaby	100	7	prokaryotes	prokaryote	NNS
cord-297078-pxggjaby	100	8	is	be	VBZ
cord-297078-pxggjaby	100	9	between	between	IN
cord-297078-pxggjaby	100	10	300	300	CD
cord-297078-pxggjaby	100	11	-	-	SYM
cord-297078-pxggjaby	100	12	400	400	CD
cord-297078-pxggjaby	100	13	amino	amino	JJ
cord-297078-pxggjaby	100	14	acids	acid	NNS
cord-297078-pxggjaby	100	15	(	(	-LRB-
cord-297078-pxggjaby	100	16	aa	aa	NNP
cord-297078-pxggjaby	100	17	)	)	-RRB-
cord-297078-pxggjaby	100	18	(	(	-LRB-
cord-297078-pxggjaby	100	19	Skovgaard	Skovgaard	NNP
cord-297078-pxggjaby	100	20	et	et	NNP
cord-297078-pxggjaby	100	21	al	al	NNP
cord-297078-pxggjaby	100	22	.	.	NNP
cord-297078-pxggjaby	100	23	2001	2001	CD
cord-297078-pxggjaby	100	24	)	)	-RRB-
cord-297078-pxggjaby	100	25	,	,	,
cord-297078-pxggjaby	100	26	equating	equate	VBG
cord-297078-pxggjaby	100	27	to	to	IN
cord-297078-pxggjaby	100	28	transcripts	transcript	NNS
cord-297078-pxggjaby	100	29	somewhere	somewhere	RB
cord-297078-pxggjaby	100	30	in	in	IN
cord-297078-pxggjaby	100	31	excess	excess	NN
cord-297078-pxggjaby	100	32	of	of	IN
cord-297078-pxggjaby	100	33	1	1	CD
cord-297078-pxggjaby	100	34	kb	kb	NNP
cord-297078-pxggjaby	100	35	.	.	.
cord-297078-pxggjaby	101	1	The	the	DT
cord-297078-pxggjaby	101	2	genome	genome	NN
cord-297078-pxggjaby	101	3	of	of	IN
cord-297078-pxggjaby	101	4	Escherichia	Escherichia	NNP
cord-297078-pxggjaby	101	5	coli	coli	VBZ
cord-297078-pxggjaby	101	6	K-12	K-12	NNP
cord-297078-pxggjaby	101	7	(	(	-LRB-
cord-297078-pxggjaby	101	8	Blattner	Blattner	NNP
cord-297078-pxggjaby	101	9	et	et	NNP
cord-297078-pxggjaby	101	10	al	al	NNP
cord-297078-pxggjaby	101	11	.	.	.
cord-297078-pxggjaby	101	12	1997	1997	CD
cord-297078-pxggjaby	101	13	)	)	-RRB-
cord-297078-pxggjaby	101	14	revealed	reveal	VBD
cord-297078-pxggjaby	101	15	the	the	DT
cord-297078-pxggjaby	101	16	longest	long	JJS
cord-297078-pxggjaby	101	17	open	open	JJ
cord-297078-pxggjaby	101	18	reading	reading	NN
cord-297078-pxggjaby	101	19	frame	frame	NN
cord-297078-pxggjaby	101	20	to	to	IN
cord-297078-pxggjaby	101	21	code	code	NN
cord-297078-pxggjaby	101	22	for	for	IN
cord-297078-pxggjaby	101	23	a	a	DT
cord-297078-pxggjaby	101	24	2,383	2,383	CD
cord-297078-pxggjaby	101	25	aa	aa	NNP
cord-297078-pxggjaby	101	26	protein	protein	NN
cord-297078-pxggjaby	101	27	.	.	.
cord-297078-pxggjaby	102	1	The	the	DT
cord-297078-pxggjaby	102	2	corresponding	corresponding	JJ
cord-297078-pxggjaby	102	3	transcript	transcript	NN
cord-297078-pxggjaby	102	4	should	should	MD
cord-297078-pxggjaby	102	5	be	be	VB
cord-297078-pxggjaby	102	6	over	over	IN
cord-297078-pxggjaby	102	7	7,200	7,200	CD
cord-297078-pxggjaby	102	8	nucleotides	nucleotide	NNS
cord-297078-pxggjaby	102	9	.	.	.
cord-297078-pxggjaby	103	1	With	with	IN
cord-297078-pxggjaby	103	2	errors	error	NNS
cord-297078-pxggjaby	103	3	on	on	IN
cord-297078-pxggjaby	103	4	the	the	DT
cord-297078-pxggjaby	103	5	order	order	NN
cord-297078-pxggjaby	103	6	of	of	IN
cord-297078-pxggjaby	103	7	every	every	DT
cord-297078-pxggjaby	103	8	10,000	10,000	CD
cord-297078-pxggjaby	103	9	bases	basis	NNS
cord-297078-pxggjaby	103	10	,	,	,
cord-297078-pxggjaby	103	11	RNA	RNA	NNP
cord-297078-pxggjaby	103	12	polymerases	polymerase	NNS
cord-297078-pxggjaby	103	13	would	would	MD
cord-297078-pxggjaby	103	14	make	make	VB
cord-297078-pxggjaby	103	15	one	one	CD
cord-297078-pxggjaby	103	16	error	error	NN
cord-297078-pxggjaby	103	17	in	in	IN
cord-297078-pxggjaby	103	18	every	every	DT
cord-297078-pxggjaby	103	19	10	10	CD
cord-297078-pxggjaby	103	20	transcripts	transcript	NNS
cord-297078-pxggjaby	103	21	in	in	IN
cord-297078-pxggjaby	103	22	bacteria	bacteria	NNS
cord-297078-pxggjaby	103	23	,	,	,
cord-297078-pxggjaby	103	24	and	and	CC
cord-297078-pxggjaby	103	25	for	for	IN
cord-297078-pxggjaby	103	26	the	the	DT
cord-297078-pxggjaby	103	27	largest	large	JJS
cord-297078-pxggjaby	103	28	E.	E.	NNP
cord-297078-pxggjaby	103	29	coli	coli	VBZ
cord-297078-pxggjaby	103	30	ORF	ORF	NNP
cord-297078-pxggjaby	103	31	errors	error	NNS
cord-297078-pxggjaby	103	32	might	may	MD
cord-297078-pxggjaby	103	33	turn	turn	VB
cord-297078-pxggjaby	103	34	up	up	RP
cord-297078-pxggjaby	103	35	in	in	IN
cord-297078-pxggjaby	103	36	2	2	CD
cord-297078-pxggjaby	103	37	of	of	IN
cord-297078-pxggjaby	103	38	3	3	CD
cord-297078-pxggjaby	103	39	transcripts	transcript	NNS
cord-297078-pxggjaby	103	40	.	.	.
cord-297078-pxggjaby	104	1	The	the	DT
cord-297078-pxggjaby	104	2	human	human	JJ
cord-297078-pxggjaby	104	3	genome	genome	NN
cord-297078-pxggjaby	104	4	encodes	encode	VBZ
cord-297078-pxggjaby	104	5	a	a	DT
cord-297078-pxggjaby	104	6	muscle	muscle	NN
cord-297078-pxggjaby	104	7	protein	protein	NN
cord-297078-pxggjaby	104	8	called	call	VBD
cord-297078-pxggjaby	104	9	titin	titin	NN
cord-297078-pxggjaby	104	10	that	that	IN
cord-297078-pxggjaby	104	11	,	,	,
cord-297078-pxggjaby	104	12	at	at	IN
cord-297078-pxggjaby	104	13	26,926	26,926	CD
cord-297078-pxggjaby	104	14	aa	aa	NNP
cord-297078-pxggjaby	104	15	,	,	,
cord-297078-pxggjaby	104	16	is	be	VBZ
cord-297078-pxggjaby	104	17	the	the	DT
cord-297078-pxggjaby	104	18	largest	large	JJS
cord-297078-pxggjaby	104	19	protein	protein	NN
cord-297078-pxggjaby	104	20	known	know	VBN
cord-297078-pxggjaby	104	21	(	(	-LRB-
cord-297078-pxggjaby	104	22	Labeit	Labeit	NNP
cord-297078-pxggjaby	104	23	and	and	CC
cord-297078-pxggjaby	104	24	Kolmerer	Kolmerer	NNP
cord-297078-pxggjaby	104	25	1995	1995	CD
cord-297078-pxggjaby	104	26	)	)	-RRB-
cord-297078-pxggjaby	104	27	.	.	.
cord-297078-pxggjaby	105	1	At	at	IN
cord-297078-pxggjaby	105	2	around	around	RB
cord-297078-pxggjaby	105	3	80	80	CD
cord-297078-pxggjaby	105	4	kb	kb	NNS
cord-297078-pxggjaby	105	5	just	just	RB
cord-297078-pxggjaby	105	6	for	for	IN
cord-297078-pxggjaby	105	7	the	the	DT
cord-297078-pxggjaby	105	8	coding	code	VBG
cord-297078-pxggjaby	105	9	region	region	NN
cord-297078-pxggjaby	105	10	(	(	-LRB-
cord-297078-pxggjaby	105	11	i.e.	i.e.	FW
cord-297078-pxggjaby	105	12	,	,	,
cord-297078-pxggjaby	105	13	minus	minus	CC
cord-297078-pxggjaby	105	14	introns	intron	NNS
cord-297078-pxggjaby	105	15	)	)	-RRB-
cord-297078-pxggjaby	105	16	,	,	,
cord-297078-pxggjaby	105	17	it	-PRON-	PRP
cord-297078-pxggjaby	105	18	would	would	MD
cord-297078-pxggjaby	105	19	be	be	VB
cord-297078-pxggjaby	105	20	expected	expect	VBN
cord-297078-pxggjaby	105	21	to	to	TO
cord-297078-pxggjaby	105	22	pick	pick	VB
cord-297078-pxggjaby	105	23	up	up	RP
cord-297078-pxggjaby	105	24	around	around	IN
cord-297078-pxggjaby	105	25	eight	eight	CD
cord-297078-pxggjaby	105	26	errors	error	NNS
cord-297078-pxggjaby	105	27	per	per	IN
cord-297078-pxggjaby	105	28	mRNA	mrna	NN
cord-297078-pxggjaby	105	29	during	during	IN
cord-297078-pxggjaby	105	30	transcription	transcription	NN
cord-297078-pxggjaby	105	31	.	.	.
cord-297078-pxggjaby	106	1	Even	even	RB
cord-297078-pxggjaby	106	2	considering	consider	VBG
cord-297078-pxggjaby	106	3	code	code	NN
cord-297078-pxggjaby	106	4	redundancy	redundancy	NN
cord-297078-pxggjaby	106	5	,	,	,
cord-297078-pxggjaby	106	6	a	a	DT
cord-297078-pxggjaby	106	7	lot	lot	NN
cord-297078-pxggjaby	106	8	of	of	IN
cord-297078-pxggjaby	106	9	mRNAs	mRNAs	NNPS
cord-297078-pxggjaby	106	10	would	would	MD
cord-297078-pxggjaby	106	11	be	be	VB
cord-297078-pxggjaby	106	12	expected	expect	VBN
cord-297078-pxggjaby	106	13	to	to	TO
cord-297078-pxggjaby	106	14	possess	possess	VB
cord-297078-pxggjaby	106	15	coding	coding	NN
cord-297078-pxggjaby	106	16	errors	error	NNS
cord-297078-pxggjaby	106	17	,	,	,
cord-297078-pxggjaby	106	18	and	and	CC
cord-297078-pxggjaby	106	19	the	the	DT
cord-297078-pxggjaby	106	20	known	know	VBN
cord-297078-pxggjaby	106	21	pathways	pathway	NNS
cord-297078-pxggjaby	106	22	of	of	IN
cord-297078-pxggjaby	106	23	mRNA	mrna	NN
cord-297078-pxggjaby	106	24	surveillance	surveillance	NN
cord-297078-pxggjaby	106	25	only	only	RB
cord-297078-pxggjaby	106	26	deal	deal	VBP
cord-297078-pxggjaby	106	27	with	with	IN
cord-297078-pxggjaby	106	28	transcripts	transcript	NNS
cord-297078-pxggjaby	106	29	with	with	IN
cord-297078-pxggjaby	106	30	premature	premature	JJ
cord-297078-pxggjaby	106	31	termination	termination	NN
cord-297078-pxggjaby	106	32	signals	signal	NNS
cord-297078-pxggjaby	106	33	(	(	-LRB-
cord-297078-pxggjaby	106	34	nonsense	nonsense	NN
cord-297078-pxggjaby	106	35	-	-	HYPH
cord-297078-pxggjaby	106	36	mediated	mediate	VBN
cord-297078-pxggjaby	106	37	decay	decay	NN
cord-297078-pxggjaby	106	38	;	;	:
cord-297078-pxggjaby	106	39	Wilusz	Wilusz	NNP
cord-297078-pxggjaby	106	40	,	,	,
cord-297078-pxggjaby	106	41	Wang	Wang	NNP
cord-297078-pxggjaby	106	42	,	,	,
cord-297078-pxggjaby	106	43	and	and	CC
cord-297078-pxggjaby	106	44	Peltz	Peltz	NNP
cord-297078-pxggjaby	106	45	[	[	-LRB-
cord-297078-pxggjaby	106	46	2001	2001	CD
cord-297078-pxggjaby	106	47	]	]	-RRB-
cord-297078-pxggjaby	106	48	)	)	-RRB-
cord-297078-pxggjaby	106	49	or	or	CC
cord-297078-pxggjaby	106	50	transcripts	transcript	NNS
cord-297078-pxggjaby	106	51	lacking	lack	VBG
cord-297078-pxggjaby	106	52	a	a	DT
cord-297078-pxggjaby	106	53	stop	stop	NN
cord-297078-pxggjaby	106	54	codon	codon	NN
cord-297078-pxggjaby	106	55	(	(	-LRB-
cord-297078-pxggjaby	106	56	nonstop	nonstop	JJ
cord-297078-pxggjaby	106	57	decay	decay	NN
cord-297078-pxggjaby	106	58	;	;	:
cord-297078-pxggjaby	106	59	Vasudevan	Vasudevan	NNP
cord-297078-pxggjaby	106	60	,	,	,
cord-297078-pxggjaby	106	61	Peltz	Peltz	NNP
cord-297078-pxggjaby	106	62	,	,	,
cord-297078-pxggjaby	106	63	and	and	CC
cord-297078-pxggjaby	106	64	Wilusz	Wilusz	NNP
cord-297078-pxggjaby	106	65	[	[	-LRB-
cord-297078-pxggjaby	106	66	2002	2002	CD
cord-297078-pxggjaby	106	67	]	]	-RRB-
cord-297078-pxggjaby	106	68	)	)	-RRB-
cord-297078-pxggjaby	106	69	.	.	.
cord-297078-pxggjaby	107	1	Without	without	IN
cord-297078-pxggjaby	107	2	some	some	DT
cord-297078-pxggjaby	107	3	form	form	NN
cord-297078-pxggjaby	107	4	of	of	IN
cord-297078-pxggjaby	107	5	proofreading	proofreading	NN
cord-297078-pxggjaby	107	6	and	and	CC
cord-297078-pxggjaby	107	7	repair	repair	NN
cord-297078-pxggjaby	107	8	,	,	,
cord-297078-pxggjaby	107	9	the	the	DT
cord-297078-pxggjaby	107	10	number	number	NN
cord-297078-pxggjaby	107	11	of	of	IN
cord-297078-pxggjaby	107	12	mRNAs	mRNAs	NNPS
cord-297078-pxggjaby	107	13	carrying	carry	VBG
cord-297078-pxggjaby	107	14	coding	coding	NN
cord-297078-pxggjaby	107	15	errors	error	NNS
cord-297078-pxggjaby	107	16	could	could	MD
cord-297078-pxggjaby	107	17	be	be	VB
cord-297078-pxggjaby	107	18	significant	significant	JJ
cord-297078-pxggjaby	107	19	.	.	.
cord-297078-pxggjaby	108	1	Though	though	IN
cord-297078-pxggjaby	108	2	we	-PRON-	PRP
cord-297078-pxggjaby	108	3	all	all	DT
cord-297078-pxggjaby	108	4	learn	learn	VBP
cord-297078-pxggjaby	108	5	that	that	DT
cord-297078-pxggjaby	108	6	proofreading	proofreading	NN
cord-297078-pxggjaby	108	7	and	and	CC
cord-297078-pxggjaby	108	8	repair	repair	NN
cord-297078-pxggjaby	108	9	is	be	VBZ
cord-297078-pxggjaby	108	10	restricted	restrict	VBN
cord-297078-pxggjaby	108	11	to	to	IN
cord-297078-pxggjaby	108	12	DNA	dna	NN
cord-297078-pxggjaby	108	13	,	,	,
cord-297078-pxggjaby	109	1	the	the	DT
cord-297078-pxggjaby	109	2	potential	potential	JJ
cord-297078-pxggjaby	109	3	benefits	benefit	NNS
cord-297078-pxggjaby	109	4	for	for	IN
cord-297078-pxggjaby	109	5	RNA	RNA	NNP
cord-297078-pxggjaby	109	6	are	be	VBP
cord-297078-pxggjaby	109	7	clear	clear	JJ
cord-297078-pxggjaby	109	8	for	for	IN
cord-297078-pxggjaby	109	9	exactly	exactly	RB
cord-297078-pxggjaby	109	10	the	the	DT
cord-297078-pxggjaby	109	11	same	same	JJ
cord-297078-pxggjaby	109	12	reason	reason	NN
cord-297078-pxggjaby	109	13	that	that	IN
cord-297078-pxggjaby	109	14	the	the	DT
cord-297078-pxggjaby	109	15	nonsense	nonsense	NN
cord-297078-pxggjaby	109	16	-	-	HYPH
cord-297078-pxggjaby	109	17	mediated	mediate	VBN
cord-297078-pxggjaby	109	18	and	and	CC
cord-297078-pxggjaby	109	19	nonstop	nonstop	JJ
cord-297078-pxggjaby	109	20	-	-	HYPH
cord-297078-pxggjaby	109	21	decay	decay	NN
cord-297078-pxggjaby	109	22	pathways	pathway	NNS
cord-297078-pxggjaby	109	23	are	be	VBP
cord-297078-pxggjaby	109	24	beneficial	beneficial	JJ
cord-297078-pxggjaby	109	25	.	.	.
cord-297078-pxggjaby	110	1	Significantly	significantly	RB
cord-297078-pxggjaby	110	2	,	,	,
cord-297078-pxggjaby	110	3	both	both	DT
cord-297078-pxggjaby	110	4	RNA	RNA	NNP
cord-297078-pxggjaby	110	5	-	-	HYPH
cord-297078-pxggjaby	110	6	and	and	CC
cord-297078-pxggjaby	110	7	DNA	dna	NN
cord-297078-pxggjaby	110	8	-	-	HYPH
cord-297078-pxggjaby	110	9	dependent	dependent	JJ
cord-297078-pxggjaby	110	10	RNA	RNA	NNP
cord-297078-pxggjaby	110	11	polymerases	polymerase	NNS
cord-297078-pxggjaby	110	12	possess	possess	VBP
cord-297078-pxggjaby	110	13	a	a	DT
cord-297078-pxggjaby	110	14	3#-5	3#-5	NNP
cord-297078-pxggjaby	110	15	#	#	NN
cord-297078-pxggjaby	110	16	nuclease	nuclease	NN
cord-297078-pxggjaby	110	17	activity	activity	NN
cord-297078-pxggjaby	110	18	,	,	,
cord-297078-pxggjaby	110	19	which	which	WDT
cord-297078-pxggjaby	110	20	is	be	VBZ
cord-297078-pxggjaby	110	21	augmented	augment	VBN
cord-297078-pxggjaby	110	22	by	by	IN
cord-297078-pxggjaby	110	23	cleavage	cleavage	NN
cord-297078-pxggjaby	110	24	-	-	HYPH
cord-297078-pxggjaby	110	25	stimulatory	stimulatory	JJ
cord-297078-pxggjaby	110	26	factors	factor	NNS
cord-297078-pxggjaby	110	27	(	(	-LRB-
cord-297078-pxggjaby	110	28	table	table	NN
cord-297078-pxggjaby	110	29	1	1	CD
cord-297078-pxggjaby	110	30	;	;	:
cord-297078-pxggjaby	110	31	Fish	Fish	NNP
cord-297078-pxggjaby	110	32	and	and	CC
cord-297078-pxggjaby	110	33	Kane	Kane	NNP
cord-297078-pxggjaby	110	34	2002	2002	CD
cord-297078-pxggjaby	110	35	)	)	-RRB-
cord-297078-pxggjaby	110	36	.	.	.
cord-297078-pxggjaby	111	1	This	this	DT
cord-297078-pxggjaby	111	2	enables	enable	VBZ
cord-297078-pxggjaby	111	3	RNA	rna	NN
cord-297078-pxggjaby	111	4	polymerases	polymerase	NNS
cord-297078-pxggjaby	111	5	to	to	TO
cord-297078-pxggjaby	111	6	negotiate	negotiate	VB
cord-297078-pxggjaby	111	7	barriers	barrier	NNS
cord-297078-pxggjaby	111	8	to	to	IN
cord-297078-pxggjaby	111	9	elongation	elongation	NN
cord-297078-pxggjaby	111	10	.	.	.
cord-297078-pxggjaby	112	1	Briefly	briefly	RB
cord-297078-pxggjaby	112	2	,	,	,
cord-297078-pxggjaby	112	3	it	-PRON-	PRP
cord-297078-pxggjaby	112	4	seems	seem	VBZ
cord-297078-pxggjaby	112	5	that	that	IN
cord-297078-pxggjaby	112	6	upon	upon	IN
cord-297078-pxggjaby	112	7	arrest	arrest	NN
cord-297078-pxggjaby	112	8	of	of	IN
cord-297078-pxggjaby	112	9	the	the	DT
cord-297078-pxggjaby	112	10	RNA	RNA	NNP
cord-297078-pxggjaby	112	11	polymerase	polymerase	NN
cord-297078-pxggjaby	112	12	at	at	IN
cord-297078-pxggjaby	112	13	some	some	DT
cord-297078-pxggjaby	112	14	barrier	barrier	NN
cord-297078-pxggjaby	112	15	to	to	IN
cord-297078-pxggjaby	112	16	elongation	elongation	NN
cord-297078-pxggjaby	112	17	,	,	,
cord-297078-pxggjaby	112	18	the	the	DT
cord-297078-pxggjaby	112	19	cleavagestimulatory	cleavagestimulatory	NN
cord-297078-pxggjaby	112	20	factors	factor	NNS
cord-297078-pxggjaby	112	21	interact	interact	VBP
cord-297078-pxggjaby	112	22	with	with	IN
cord-297078-pxggjaby	112	23	the	the	DT
cord-297078-pxggjaby	112	24	polymerase	polymerase	NN
cord-297078-pxggjaby	112	25	,	,	,
cord-297078-pxggjaby	112	26	causing	cause	VBG
cord-297078-pxggjaby	112	27	it	-PRON-	PRP
cord-297078-pxggjaby	112	28	to	to	TO
cord-297078-pxggjaby	112	29	backtrack	backtrack	VB
cord-297078-pxggjaby	112	30	and	and	CC
cord-297078-pxggjaby	112	31	hydrolyze	hydrolyze	VB
cord-297078-pxggjaby	112	32	the	the	DT
cord-297078-pxggjaby	112	33	nascent	nascent	JJ
cord-297078-pxggjaby	112	34	transcript	transcript	NN
cord-297078-pxggjaby	112	35	.	.	.
cord-297078-pxggjaby	113	1	Elongation	elongation	NN
cord-297078-pxggjaby	113	2	is	be	VBZ
cord-297078-pxggjaby	113	3	then	then	RB
cord-297078-pxggjaby	113	4	reinitiated	reinitiate	VBN
cord-297078-pxggjaby	113	5	.	.	.
cord-297078-pxggjaby	114	1	The	the	DT
cord-297078-pxggjaby	114	2	ability	ability	NN
cord-297078-pxggjaby	114	3	to	to	TO
cord-297078-pxggjaby	114	4	negotiate	negotiate	VB
cord-297078-pxggjaby	114	5	blocks	block	NNS
cord-297078-pxggjaby	114	6	to	to	IN
cord-297078-pxggjaby	114	7	elongation	elongation	NN
cord-297078-pxggjaby	114	8	(	(	-LRB-
cord-297078-pxggjaby	114	9	which	which	WDT
cord-297078-pxggjaby	114	10	includes	include	VBZ
cord-297078-pxggjaby	114	11	misincorporation	misincorporation	NNP
cord-297078-pxggjaby	114	12	)	)	-RRB-
cord-297078-pxggjaby	114	13	has	have	VBZ
cord-297078-pxggjaby	114	14	been	be	VBN
cord-297078-pxggjaby	114	15	interpreted	interpret	VBN
cord-297078-pxggjaby	114	16	as	as	IN
cord-297078-pxggjaby	114	17	improving	improve	VBG
cord-297078-pxggjaby	114	18	the	the	DT
cord-297078-pxggjaby	114	19	fidelity	fidelity	NN
cord-297078-pxggjaby	114	20	of	of	IN
cord-297078-pxggjaby	114	21	the	the	DT
cord-297078-pxggjaby	114	22	process	process	NN
cord-297078-pxggjaby	114	23	and	and	CC
cord-297078-pxggjaby	114	24	therefore	therefore	RB
cord-297078-pxggjaby	114	25	playing	play	VBG
cord-297078-pxggjaby	114	26	a	a	DT
cord-297078-pxggjaby	114	27	part	part	NN
cord-297078-pxggjaby	114	28	in	in	IN
cord-297078-pxggjaby	114	29	quality	quality	NN
cord-297078-pxggjaby	114	30	control	control	NN
cord-297078-pxggjaby	114	31	of	of	IN
cord-297078-pxggjaby	114	32	transcripts	transcript	NNS
cord-297078-pxggjaby	115	1	(	(	-LRB-
cord-297078-pxggjaby	115	2	Erie	Erie	NNP
cord-297078-pxggjaby	115	3	et	et	NNP
cord-297078-pxggjaby	115	4	al	al	NNP
cord-297078-pxggjaby	115	5	.	.	NNP
cord-297078-pxggjaby	115	6	1993	1993	CD
cord-297078-pxggjaby	115	7	;	;	:
cord-297078-pxggjaby	115	8	Jeon	Jeon	NNP
cord-297078-pxggjaby	115	9	and	and	CC
cord-297078-pxggjaby	115	10	Agarwal	Agarwal	NNP
cord-297078-pxggjaby	115	11	1996	1996	CD
cord-297078-pxggjaby	115	12	)	)	-RRB-
cord-297078-pxggjaby	115	13	.	.	.
cord-297078-pxggjaby	116	1	This	this	DT
cord-297078-pxggjaby	116	2	might	may	MD
cord-297078-pxggjaby	116	3	well	well	RB
cord-297078-pxggjaby	116	4	be	be	VB
cord-297078-pxggjaby	116	5	interpreted	interpret	VBN
cord-297078-pxggjaby	116	6	as	as	IN
cord-297078-pxggjaby	116	7	a	a	DT
cord-297078-pxggjaby	116	8	form	form	NN
cord-297078-pxggjaby	116	9	of	of	IN
cord-297078-pxggjaby	116	10	proofreading	proofreading	NN
cord-297078-pxggjaby	116	11	,	,	,
cord-297078-pxggjaby	116	12	and	and	CC
cord-297078-pxggjaby	116	13	indeed	indeed	RB
cord-297078-pxggjaby	116	14	,	,	,
cord-297078-pxggjaby	116	15	initial	initial	JJ
cord-297078-pxggjaby	116	16	identification	identification	NN
cord-297078-pxggjaby	116	17	of	of	IN
cord-297078-pxggjaby	116	18	3#-5	3#-5	NNP
cord-297078-pxggjaby	116	19	#	#	NN
cord-297078-pxggjaby	116	20	nuclease	nuclease	NN
cord-297078-pxggjaby	116	21	activity	activity	NN
cord-297078-pxggjaby	116	22	in	in	IN
cord-297078-pxggjaby	116	23	the	the	DT
cord-297078-pxggjaby	116	24	single	single	JJ
cord-297078-pxggjaby	116	25	subunit	subunit	NN
cord-297078-pxggjaby	116	26	RNA	rna	NN
cord-297078-pxggjaby	116	27	-	-	HYPH
cord-297078-pxggjaby	116	28	dependent	dependent	JJ
cord-297078-pxggjaby	116	29	RNA	RNA	NNP
cord-297078-pxggjaby	116	30	polymerase	polymerase	NN
cord-297078-pxggjaby	116	31	from	from	IN
cord-297078-pxggjaby	116	32	influenza	influenza	NN
cord-297078-pxggjaby	116	33	virus	virus	NN
cord-297078-pxggjaby	116	34	(	(	-LRB-
cord-297078-pxggjaby	116	35	Ishihama	Ishihama	NNP
cord-297078-pxggjaby	116	36	et	et	NNP
cord-297078-pxggjaby	116	37	al	al	NNP
cord-297078-pxggjaby	116	38	.	.	NNP
cord-297078-pxggjaby	116	39	1986	1986	CD
cord-297078-pxggjaby	116	40	)	)	-RRB-
cord-297078-pxggjaby	116	41	led	lead	VBD
cord-297078-pxggjaby	116	42	to	to	IN
cord-297078-pxggjaby	116	43	speculation	speculation	NN
cord-297078-pxggjaby	116	44	that	that	IN
cord-297078-pxggjaby	116	45	RNA	RNA	NNP
cord-297078-pxggjaby	116	46	polymerases	polymerase	NNS
cord-297078-pxggjaby	116	47	,	,	,
cord-297078-pxggjaby	116	48	like	like	IN
cord-297078-pxggjaby	116	49	many	many	JJ
cord-297078-pxggjaby	116	50	of	of	IN
cord-297078-pxggjaby	116	51	their	-PRON-	PRP$
cord-297078-pxggjaby	116	52	DNA	dna	NN
cord-297078-pxggjaby	116	53	counterparts	counterpart	NNS
cord-297078-pxggjaby	116	54	,	,	,
cord-297078-pxggjaby	116	55	possessed	possess	VBD
cord-297078-pxggjaby	116	56	proofreading	proofreading	NN
cord-297078-pxggjaby	116	57	(	(	-LRB-
cord-297078-pxggjaby	116	58	Shirai	Shirai	NNP
cord-297078-pxggjaby	116	59	and	and	CC
cord-297078-pxggjaby	116	60	Go	Go	NNP
cord-297078-pxggjaby	116	61	1991	1991	CD
cord-297078-pxggjaby	116	62	)	)	-RRB-
cord-297078-pxggjaby	116	63	.	.	.
cord-297078-pxggjaby	117	1	Experiments	experiment	NNS
cord-297078-pxggjaby	117	2	on	on	IN
cord-297078-pxggjaby	117	3	misincorporations	misincorporation	NNS
cord-297078-pxggjaby	117	4	suggested	suggest	VBD
cord-297078-pxggjaby	117	5	that	that	IN
cord-297078-pxggjaby	117	6	mRNA	mRNA	NNP
cord-297078-pxggjaby	117	7	transcription	transcription	NN
cord-297078-pxggjaby	117	8	was	be	VBD
cord-297078-pxggjaby	117	9	subject	subject	JJ
cord-297078-pxggjaby	117	10	to	to	IN
cord-297078-pxggjaby	117	11	a	a	DT
cord-297078-pxggjaby	117	12	high	high	JJ
cord-297078-pxggjaby	117	13	degree	degree	NN
cord-297078-pxggjaby	117	14	of	of	IN
cord-297078-pxggjaby	117	15	fidelity	fidelity	NN
cord-297078-pxggjaby	117	16	in	in	IN
cord-297078-pxggjaby	117	17	both	both	DT
cord-297078-pxggjaby	117	18	bacteria	bacteria	NNS
cord-297078-pxggjaby	117	19	and	and	CC
cord-297078-pxggjaby	117	20	eukaryotes	eukaryote	NNS
cord-297078-pxggjaby	118	1	(	(	-LRB-
cord-297078-pxggjaby	118	2	Erie	Erie	NNP
cord-297078-pxggjaby	118	3	et	et	NNP
cord-297078-pxggjaby	118	4	al	al	NNP
cord-297078-pxggjaby	118	5	.	.	NNP
cord-297078-pxggjaby	118	6	1993	1993	CD
cord-297078-pxggjaby	118	7	;	;	:
cord-297078-pxggjaby	118	8	Jeon	Jeon	NNP
cord-297078-pxggjaby	118	9	and	and	CC
cord-297078-pxggjaby	118	10	Agarwal	Agarwal	NNP
cord-297078-pxggjaby	118	11	1996	1996	CD
cord-297078-pxggjaby	118	12	)	)	-RRB-
cord-297078-pxggjaby	119	1	though	though	IN
cord-297078-pxggjaby	119	2	a	a	DT
cord-297078-pxggjaby	119	3	direct	direct	JJ
cord-297078-pxggjaby	119	4	role	role	NN
cord-297078-pxggjaby	119	5	in	in	IN
cord-297078-pxggjaby	119	6	proofreading	proofreading	NN
cord-297078-pxggjaby	119	7	was	be	VBD
cord-297078-pxggjaby	119	8	not	not	RB
cord-297078-pxggjaby	119	9	demonstrated	demonstrate	VBN
cord-297078-pxggjaby	119	10	.	.	.
cord-297078-pxggjaby	120	1	Thomas	Thomas	NNP
cord-297078-pxggjaby	120	2	,	,	,
cord-297078-pxggjaby	120	3	Platas	Platas	NNP
cord-297078-pxggjaby	120	4	,	,	,
cord-297078-pxggjaby	120	5	and	and	CC
cord-297078-pxggjaby	120	6	Hawley	Hawley	NNP
cord-297078-pxggjaby	120	7	(	(	-LRB-
cord-297078-pxggjaby	120	8	1998	1998	CD
cord-297078-pxggjaby	120	9	)	)	-RRB-
cord-297078-pxggjaby	120	10	subsequently	subsequently	RB
cord-297078-pxggjaby	120	11	presented	present	VBN
cord-297078-pxggjaby	120	12	in	in	IN
cord-297078-pxggjaby	120	13	vitro	vitro	FW
cord-297078-pxggjaby	120	14	evidence	evidence	NN
cord-297078-pxggjaby	120	15	for	for	IN
cord-297078-pxggjaby	120	16	proofreading	proofread	VBG
cord-297078-pxggjaby	120	17	by	by	IN
cord-297078-pxggjaby	120	18	RNA	RNA	NNP
cord-297078-pxggjaby	120	19	polymerase	polymerase	NN
cord-297078-pxggjaby	120	20	II	II	NNP
cord-297078-pxggjaby	120	21	(	(	-LRB-
cord-297078-pxggjaby	120	22	pol	pol	NNP
cord-297078-pxggjaby	120	23	II	II	NNP
cord-297078-pxggjaby	120	24	)	)	-RRB-
cord-297078-pxggjaby	120	25	.	.	.
cord-297078-pxggjaby	121	1	Upon	upon	IN
cord-297078-pxggjaby	121	2	misincorporation	misincorporation	NN
cord-297078-pxggjaby	121	3	of	of	IN
cord-297078-pxggjaby	121	4	a	a	DT
cord-297078-pxggjaby	121	5	nucleotide	nucleotide	NN
cord-297078-pxggjaby	121	6	in	in	IN
cord-297078-pxggjaby	121	7	the	the	DT
cord-297078-pxggjaby	121	8	growing	grow	VBG
cord-297078-pxggjaby	121	9	RNA	RNA	NNP
cord-297078-pxggjaby	121	10	,	,	,
cord-297078-pxggjaby	121	11	the	the	DT
cord-297078-pxggjaby	121	12	addition	addition	NN
cord-297078-pxggjaby	121	13	of	of	IN
cord-297078-pxggjaby	121	14	the	the	DT
cord-297078-pxggjaby	121	15	next	next	JJ
cord-297078-pxggjaby	121	16	nucleotide	nucleotide	NN
cord-297078-pxggjaby	121	17	is	be	VBZ
cord-297078-pxggjaby	121	18	slowed	slow	VBN
cord-297078-pxggjaby	121	19	,	,	,
cord-297078-pxggjaby	121	20	with	with	IN
cord-297078-pxggjaby	121	21	extension	extension	NN
cord-297078-pxggjaby	121	22	occurring	occur	VBG
cord-297078-pxggjaby	121	23	between	between	IN
cord-297078-pxggjaby	121	24	5-and	5-and	CD
cord-297078-pxggjaby	121	25	20-fold	20-fold	CD
cord-297078-pxggjaby	121	26	slower	slow	JJR
cord-297078-pxggjaby	121	27	than	than	IN
cord-297078-pxggjaby	121	28	for	for	IN
cord-297078-pxggjaby	121	29	a	a	DT
cord-297078-pxggjaby	121	30	correct	correct	JJ
cord-297078-pxggjaby	121	31	incorporation	incorporation	NN
cord-297078-pxggjaby	121	32	.	.	.
cord-297078-pxggjaby	122	1	This	this	DT
cord-297078-pxggjaby	122	2	delay	delay	NN
cord-297078-pxggjaby	122	3	provides	provide	VBZ
cord-297078-pxggjaby	122	4	time	time	NN
cord-297078-pxggjaby	122	5	for	for	IN
cord-297078-pxggjaby	122	6	the	the	DT
cord-297078-pxggjaby	122	7	cleavage	cleavage	NN
cord-297078-pxggjaby	122	8	-	-	HYPH
cord-297078-pxggjaby	122	9	stimulatory	stimulatory	JJ
cord-297078-pxggjaby	122	10	factor	factor	NN
cord-297078-pxggjaby	122	11	,	,	,
cord-297078-pxggjaby	122	12	transcription	transcription	NN
cord-297078-pxggjaby	122	13	factor	factor	NN
cord-297078-pxggjaby	122	14	IIS	IIS	NNP
cord-297078-pxggjaby	122	15	(	(	-LRB-
cord-297078-pxggjaby	122	16	TFIIS	TFIIS	NNP
cord-297078-pxggjaby	122	17	)	)	-RRB-
cord-297078-pxggjaby	122	18	to	to	TO
cord-297078-pxggjaby	122	19	bind	bind	VB
cord-297078-pxggjaby	122	20	arrested	arrest	VBN
cord-297078-pxggjaby	122	21	pol	pol	NN
cord-297078-pxggjaby	122	22	II	II	NNP
cord-297078-pxggjaby	122	23	,	,	,
cord-297078-pxggjaby	122	24	stimulating	stimulate	VBG
cord-297078-pxggjaby	122	25	removal	removal	NN
cord-297078-pxggjaby	122	26	of	of	IN
cord-297078-pxggjaby	122	27	the	the	DT
cord-297078-pxggjaby	122	28	mismatched	mismatched	JJ
cord-297078-pxggjaby	122	29	nucleotide	nucleotide	NN
cord-297078-pxggjaby	122	30	via	via	IN
cord-297078-pxggjaby	122	31	the	the	DT
cord-297078-pxggjaby	122	32	intrinsic	intrinsic	JJ
cord-297078-pxggjaby	122	33	PolII	polii	NN
cord-297078-pxggjaby	122	34	3#-5	3#-5	NNP
cord-297078-pxggjaby	122	35	#	#	NN
cord-297078-pxggjaby	122	36	exonuclease	exonuclease	NN
cord-297078-pxggjaby	122	37	activity	activity	NN
cord-297078-pxggjaby	122	38	(	(	-LRB-
cord-297078-pxggjaby	122	39	Wind	Wind	NNP
cord-297078-pxggjaby	122	40	and	and	CC
cord-297078-pxggjaby	122	41	Reines	Reines	NNP
cord-297078-pxggjaby	122	42	2000	2000	CD
cord-297078-pxggjaby	122	43	)	)	-RRB-
cord-297078-pxggjaby	122	44	.	.	.
cord-297078-pxggjaby	123	1	Removal	removal	NN
cord-297078-pxggjaby	123	2	of	of	IN
cord-297078-pxggjaby	123	3	the	the	DT
cord-297078-pxggjaby	123	4	misincorporated	misincorporate	VBN
cord-297078-pxggjaby	123	5	nucleotide	nucleotide	NNP
cord-297078-pxggjaby	123	6	was	be	VBD
cord-297078-pxggjaby	123	7	observed	observe	VBN
cord-297078-pxggjaby	123	8	at	at	IN
cord-297078-pxggjaby	123	9	low	low	JJ
cord-297078-pxggjaby	123	10	levels	level	NNS
cord-297078-pxggjaby	123	11	in	in	IN
cord-297078-pxggjaby	123	12	the	the	DT
cord-297078-pxggjaby	123	13	absence	absence	NN
cord-297078-pxggjaby	123	14	of	of	IN
cord-297078-pxggjaby	123	15	TFIIS	TFIIS	NNP
cord-297078-pxggjaby	123	16	,	,	,
cord-297078-pxggjaby	123	17	and	and	CC
cord-297078-pxggjaby	123	18	this	this	DT
cord-297078-pxggjaby	123	19	is	be	VBZ
cord-297078-pxggjaby	123	20	known	know	VBN
cord-297078-pxggjaby	123	21	to	to	TO
cord-297078-pxggjaby	123	22	be	be	VB
cord-297078-pxggjaby	123	23	the	the	DT
cord-297078-pxggjaby	123	24	case	case	NN
cord-297078-pxggjaby	123	25	for	for	IN
cord-297078-pxggjaby	123	26	a	a	DT
cord-297078-pxggjaby	123	27	number	number	NN
cord-297078-pxggjaby	123	28	of	of	IN
cord-297078-pxggjaby	123	29	RNA	RNA	NNP
cord-297078-pxggjaby	123	30	polymerases	polymerase	NNS
cord-297078-pxggjaby	123	31	.	.	.
cord-297078-pxggjaby	124	1	The	the	DT
cord-297078-pxggjaby	124	2	work	work	NN
cord-297078-pxggjaby	124	3	on	on	IN
cord-297078-pxggjaby	124	4	human	human	JJ
cord-297078-pxggjaby	124	5	RNA	RNA	NNP
cord-297078-pxggjaby	124	6	pol	pol	NN
cord-297078-pxggjaby	124	7	II	II	NNP
cord-297078-pxggjaby	124	8	provides	provide	VBZ
cord-297078-pxggjaby	124	9	clear	clear	JJ
cord-297078-pxggjaby	124	10	evidence	evidence	NN
cord-297078-pxggjaby	124	11	for	for	IN
cord-297078-pxggjaby	124	12	RNA	rna	NN
cord-297078-pxggjaby	124	13	polymerase	polymerase	NN
cord-297078-pxggjaby	124	14	-	-	HYPH
cord-297078-pxggjaby	124	15	dependent	dependent	JJ
cord-297078-pxggjaby	124	16	proofreading	proofreading	NN
cord-297078-pxggjaby	124	17	and	and	CC
cord-297078-pxggjaby	124	18	error	error	NN
cord-297078-pxggjaby	124	19	correction	correction	NN
cord-297078-pxggjaby	124	20	,	,	,
cord-297078-pxggjaby	124	21	but	but	CC
cord-297078-pxggjaby	124	22	other	other	JJ
cord-297078-pxggjaby	124	23	polymerases	polymerase	NNS
cord-297078-pxggjaby	124	24	also	also	RB
cord-297078-pxggjaby	124	25	possess	possess	VBP
cord-297078-pxggjaby	124	26	this	this	DT
cord-297078-pxggjaby	124	27	capacity	capacity	NN
cord-297078-pxggjaby	124	28	(	(	-LRB-
cord-297078-pxggjaby	124	29	table	table	NN
cord-297078-pxggjaby	124	30	1	1	CD
cord-297078-pxggjaby	124	31	)	)	-RRB-
cord-297078-pxggjaby	124	32	.	.	.
cord-297078-pxggjaby	125	1	Recently	recently	RB
cord-297078-pxggjaby	125	2	,	,	,
cord-297078-pxggjaby	125	3	several	several	JJ
cord-297078-pxggjaby	125	4	important	important	JJ
cord-297078-pxggjaby	125	5	papers	paper	NNS
cord-297078-pxggjaby	125	6	shed	shed	VBP
cord-297078-pxggjaby	125	7	further	further	JJ
cord-297078-pxggjaby	125	8	light	light	NN
cord-297078-pxggjaby	125	9	on	on	IN
cord-297078-pxggjaby	125	10	this	this	DT
cord-297078-pxggjaby	125	11	process	process	NN
cord-297078-pxggjaby	125	12	.	.	.
cord-297078-pxggjaby	126	1	Shaevitz	Shaevitz	NNP
cord-297078-pxggjaby	126	2	et	et	NNP
cord-297078-pxggjaby	126	3	al	al	NNP
cord-297078-pxggjaby	126	4	.	.	.
cord-297078-pxggjaby	127	1	(	(	-LRB-
cord-297078-pxggjaby	127	2	2003	2003	CD
cord-297078-pxggjaby	127	3	)	)	-RRB-
cord-297078-pxggjaby	127	4	presented	present	VBD
cord-297078-pxggjaby	127	5	an	an	DT
cord-297078-pxggjaby	127	6	optical	optical	JJ
cord-297078-pxggjaby	127	7	trapping	trapping	NN
cord-297078-pxggjaby	127	8	study	study	NN
cord-297078-pxggjaby	127	9	of	of	IN
cord-297078-pxggjaby	127	10	the	the	DT
cord-297078-pxggjaby	127	11	RNA	RNA	NNP
cord-297078-pxggjaby	127	12	polymerase	polymerase	NN
cord-297078-pxggjaby	127	13	(	(	-LRB-
cord-297078-pxggjaby	127	14	RNAP	RNAP	NNP
cord-297078-pxggjaby	127	15	)	)	-RRB-
cord-297078-pxggjaby	127	16	from	from	IN
cord-297078-pxggjaby	127	17	E.	E.	NNP
cord-297078-pxggjaby	127	18	coli	coli	NNS
cord-297078-pxggjaby	127	19	,	,	,
cord-297078-pxggjaby	127	20	showing	show	VBG
cord-297078-pxggjaby	127	21	backtracking	backtracking	NN
cord-297078-pxggjaby	127	22	and	and	CC
cord-297078-pxggjaby	127	23	recovery	recovery	NN
cord-297078-pxggjaby	127	24	from	from	IN
cord-297078-pxggjaby	127	25	pausing	pause	VBG
cord-297078-pxggjaby	127	26	by	by	IN
cord-297078-pxggjaby	127	27	single	single	JJ
cord-297078-pxggjaby	127	28	molecules	molecule	NNS
cord-297078-pxggjaby	127	29	of	of	IN
cord-297078-pxggjaby	127	30	RNAP	RNAP	NNP
cord-297078-pxggjaby	127	31	.	.	.
cord-297078-pxggjaby	128	1	Pausing	pause	VBG
cord-297078-pxggjaby	128	2	was	be	VBD
cord-297078-pxggjaby	128	3	significantly	significantly	RB
cord-297078-pxggjaby	128	4	reduced	reduce	VBN
cord-297078-pxggjaby	128	5	by	by	IN
cord-297078-pxggjaby	128	6	growth	growth	NN
cord-297078-pxggjaby	128	7	regulator	regulator	NN
cord-297078-pxggjaby	128	8	A	A	NNP
cord-297078-pxggjaby	128	9	(	(	-LRB-
cord-297078-pxggjaby	128	10	GreA	GreA	NNP
cord-297078-pxggjaby	128	11	)	)	-RRB-
cord-297078-pxggjaby	128	12	or	or	CC
cord-297078-pxggjaby	128	13	growth	growth	NN
cord-297078-pxggjaby	128	14	regulator	regulator	NN
cord-297078-pxggjaby	128	15	B	b	NN
cord-297078-pxggjaby	128	16	(	(	-LRB-
cord-297078-pxggjaby	128	17	GreB)-induced	greb)-induce	VBN
cord-297078-pxggjaby	128	18	cleavage	cleavage	NN
cord-297078-pxggjaby	128	19	.	.	.
cord-297078-pxggjaby	129	1	demonstrated	demonstrate	VBN
cord-297078-pxggjaby	129	2	by	by	IN
cord-297078-pxggjaby	129	3	an	an	DT
cord-297078-pxggjaby	129	4	elegant	elegant	JJ
cord-297078-pxggjaby	129	5	exploitation	exploitation	NN
cord-297078-pxggjaby	129	6	of	of	IN
cord-297078-pxggjaby	129	7	the	the	DT
cord-297078-pxggjaby	129	8	intrinsic	intrinsic	JJ
cord-297078-pxggjaby	129	9	exonuclease	exonuclease	NN
cord-297078-pxggjaby	129	10	activity	activity	NN
cord-297078-pxggjaby	129	11	of	of	IN
cord-297078-pxggjaby	129	12	E.	E.	NNP
cord-297078-pxggjaby	129	13	coli	coli	NNS
cord-297078-pxggjaby	129	14	RNAP	RNAP	NNP
cord-297078-pxggjaby	129	15	,	,	,
cord-297078-pxggjaby	129	16	combined	combine	VBN
cord-297078-pxggjaby	129	17	with	with	IN
cord-297078-pxggjaby	129	18	mutagenesis	mutagenesis	NN
cord-297078-pxggjaby	129	19	and	and	CC
cord-297078-pxggjaby	129	20	modeling	modeling	NN
cord-297078-pxggjaby	129	21	,	,	,
cord-297078-pxggjaby	129	22	that	that	IN
cord-297078-pxggjaby	129	23	a	a	DT
cord-297078-pxggjaby	129	24	common	common	JJ
cord-297078-pxggjaby	129	25	two	two	CD
cord-297078-pxggjaby	129	26	-	-	HYPH
cord-297078-pxggjaby	129	27	metal	metal	NN
cord-297078-pxggjaby	129	28	mechanism	mechanism	NN
cord-297078-pxggjaby	129	29	is	be	VBZ
cord-297078-pxggjaby	129	30	used	use	VBN
cord-297078-pxggjaby	129	31	for	for	IN
cord-297078-pxggjaby	129	32	both	both	DT
cord-297078-pxggjaby	129	33	elongation	elongation	NN
cord-297078-pxggjaby	129	34	and	and	CC
cord-297078-pxggjaby	129	35	repair	repair	NN
cord-297078-pxggjaby	129	36	(	(	-LRB-
cord-297078-pxggjaby	129	37	fig	fig	NN
cord-297078-pxggjaby	129	38	.	.	NNP
cord-297078-pxggjaby	129	39	2	2	LS
cord-297078-pxggjaby	129	40	)	)	-RRB-
cord-297078-pxggjaby	129	41	,	,	,
cord-297078-pxggjaby	129	42	in	in	IN
cord-297078-pxggjaby	129	43	a	a	DT
cord-297078-pxggjaby	129	44	manner	manner	NN
cord-297078-pxggjaby	129	45	similar	similar	JJ
cord-297078-pxggjaby	129	46	to	to	IN
cord-297078-pxggjaby	129	47	that	that	DT
cord-297078-pxggjaby	129	48	proposed	propose	VBN
cord-297078-pxggjaby	129	49	for	for	IN
cord-297078-pxggjaby	129	50	the	the	DT
cord-297078-pxggjaby	129	51	3#-5	3#-5	NNP
cord-297078-pxggjaby	129	52	#	#	NN
cord-297078-pxggjaby	129	53	exonuclease	exonuclease	NN
cord-297078-pxggjaby	129	54	activity	activity	NN
cord-297078-pxggjaby	129	55	of	of	IN
cord-297078-pxggjaby	129	56	DNA	dna	NN
cord-297078-pxggjaby	129	57	polymerases	polymerase	NNS
cord-297078-pxggjaby	129	58	(	(	-LRB-
cord-297078-pxggjaby	129	59	Joyce	Joyce	NNP
cord-297078-pxggjaby	129	60	and	and	CC
cord-297078-pxggjaby	129	61	Steitz	Steitz	NNP
cord-297078-pxggjaby	129	62	1994	1994	CD
cord-297078-pxggjaby	129	63	)	)	-RRB-
cord-297078-pxggjaby	129	64	.	.	.
cord-297078-pxggjaby	130	1	Two	two	CD
cord-297078-pxggjaby	130	2	further	further	JJ
cord-297078-pxggjaby	130	3	papers	paper	NNS
cord-297078-pxggjaby	130	4	showed	show	VBD
cord-297078-pxggjaby	130	5	surprising	surprising	JJ
cord-297078-pxggjaby	130	6	similarities	similarity	NNS
cord-297078-pxggjaby	130	7	in	in	IN
cord-297078-pxggjaby	130	8	the	the	DT
cord-297078-pxggjaby	130	9	roles	role	NNS
cord-297078-pxggjaby	130	10	of	of	IN
cord-297078-pxggjaby	130	11	the	the	DT
cord-297078-pxggjaby	130	12	prokaryotic	prokaryotic	JJ
cord-297078-pxggjaby	130	13	and	and	CC
cord-297078-pxggjaby	130	14	eukaryotic	eukaryotic	JJ
cord-297078-pxggjaby	130	15	transcription	transcription	NN
cord-297078-pxggjaby	130	16	factors	factor	NNS
cord-297078-pxggjaby	130	17	in	in	IN
cord-297078-pxggjaby	130	18	stimulation	stimulation	NN
cord-297078-pxggjaby	130	19	of	of	IN
cord-297078-pxggjaby	130	20	the	the	DT
cord-297078-pxggjaby	130	21	endonuclease	endonuclease	NN
cord-297078-pxggjaby	130	22	activity	activity	NN
cord-297078-pxggjaby	130	23	(	(	-LRB-
cord-297078-pxggjaby	130	24	fig	fig	NN
cord-297078-pxggjaby	130	25	.	.	.
cord-297078-pxggjaby	130	26	3ad	3ad	NNP
cord-297078-pxggjaby	130	27	)	)	-RRB-
cord-297078-pxggjaby	130	28	.	.	.
cord-297078-pxggjaby	131	1	In	in	IN
cord-297078-pxggjaby	131	2	a	a	DT
cord-297078-pxggjaby	131	3	medium	medium	JJ
cord-297078-pxggjaby	131	4	-	-	HYPH
cord-297078-pxggjaby	131	5	resolution	resolution	NN
cord-297078-pxggjaby	131	6	(	(	-LRB-
cord-297078-pxggjaby	131	7	3.8	3.8	CD
cord-297078-pxggjaby	131	8	Å	å	NN
cord-297078-pxggjaby	131	9	)	)	-RRB-
cord-297078-pxggjaby	131	10	study	study	NN
cord-297078-pxggjaby	131	11	of	of	IN
cord-297078-pxggjaby	131	12	the	the	DT
cord-297078-pxggjaby	131	13	binding	binding	NN
cord-297078-pxggjaby	131	14	of	of	IN
cord-297078-pxggjaby	131	15	TFIIS	TFIIS	NNP
cord-297078-pxggjaby	131	16	to	to	IN
cord-297078-pxggjaby	131	17	yeast	yeast	NN
cord-297078-pxggjaby	131	18	pol	pol	NN
cord-297078-pxggjaby	131	19	II	II	NNP
cord-297078-pxggjaby	132	1	(	(	-LRB-
cord-297078-pxggjaby	132	2	Kettenberger	Kettenberger	NNP
cord-297078-pxggjaby	132	3	,	,	,
cord-297078-pxggjaby	132	4	Armache	Armache	NNP
cord-297078-pxggjaby	132	5	,	,	,
cord-297078-pxggjaby	132	6	and	and	CC
cord-297078-pxggjaby	132	7	Cramer	Cramer	NNP
cord-297078-pxggjaby	132	8	FIG	FIG	NNP
cord-297078-pxggjaby	132	9	.	.	.
cord-297078-pxggjaby	133	1	2.-Schematic	2.-schematic	CD
cord-297078-pxggjaby	133	2	diagram	diagram	NN
cord-297078-pxggjaby	133	3	of	of	IN
cord-297078-pxggjaby	133	4	the	the	DT
cord-297078-pxggjaby	133	5	transcription	transcription	NN
cord-297078-pxggjaby	133	6	factor	factor	NN
cord-297078-pxggjaby	133	7	-	-	HYPH
cord-297078-pxggjaby	133	8	catalyzed	catalyze	VBN
cord-297078-pxggjaby	133	9	twometal	twometal	JJ
cord-297078-pxggjaby	133	10	ion	ion	NN
cord-297078-pxggjaby	133	11	mechanism	mechanism	NN
cord-297078-pxggjaby	133	12	for	for	IN
cord-297078-pxggjaby	133	13	the	the	DT
cord-297078-pxggjaby	133	14	3#-5	3#-5	NNP
cord-297078-pxggjaby	133	15	#	#	NN
cord-297078-pxggjaby	133	16	exonuclease	exonuclease	NN
cord-297078-pxggjaby	133	17	activity	activity	NN
cord-297078-pxggjaby	133	18	as	as	IN
cord-297078-pxggjaby	133	19	proposed	propose	VBN
cord-297078-pxggjaby	133	20	by	by	IN
cord-297078-pxggjaby	133	21	Sosunova	Sosunova	NNP
cord-297078-pxggjaby	133	22	et	et	NNP
cord-297078-pxggjaby	133	23	al	al	NNP
cord-297078-pxggjaby	133	24	.	.	.
cord-297078-pxggjaby	134	1	(	(	-LRB-
cord-297078-pxggjaby	134	2	2003	2003	CD
cord-297078-pxggjaby	134	3	)	)	-RRB-
cord-297078-pxggjaby	134	4	,	,	,
cord-297078-pxggjaby	134	5	extended	extend	VBN
cord-297078-pxggjaby	134	6	to	to	IN
cord-297078-pxggjaby	134	7	both	both	CC
cord-297078-pxggjaby	134	8	the	the	DT
cord-297078-pxggjaby	134	9	prokaryotic	prokaryotic	JJ
cord-297078-pxggjaby	134	10	and	and	CC
cord-297078-pxggjaby	134	11	eukaryotic	eukaryotic	JJ
cord-297078-pxggjaby	134	12	polymerases	polymerase	NNS
cord-297078-pxggjaby	134	13	.	.	.
cord-297078-pxggjaby	135	1	RNA	RNA	NNP
cord-297078-pxggjaby	135	2	Repair	Repair	NNP
cord-297078-pxggjaby	135	3	in	in	IN
cord-297078-pxggjaby	135	4	the	the	DT
cord-297078-pxggjaby	135	5	Last	last	JJ
cord-297078-pxggjaby	135	6	Universal	Universal	NNP
cord-297078-pxggjaby	135	7	Common	Common	NNP
cord-297078-pxggjaby	135	8	Ancestor	Ancestor	NNP
cord-297078-pxggjaby	135	9	1447	1447	CD
cord-297078-pxggjaby	135	10	2003	2003	CD
cord-297078-pxggjaby	135	11	,	,	,
cord-297078-pxggjaby	135	12	2004	2004	CD
cord-297078-pxggjaby	135	13	)	)	-RRB-
cord-297078-pxggjaby	136	1	,	,	,
cord-297078-pxggjaby	136	2	the	the	DT
cord-297078-pxggjaby	136	3	highly	highly	RB
cord-297078-pxggjaby	136	4	extended	extended	JJ
cord-297078-pxggjaby	136	5	TFIIS	TFIIS	NNP
cord-297078-pxggjaby	136	6	is	be	VBZ
cord-297078-pxggjaby	136	7	seen	see	VBN
cord-297078-pxggjaby	136	8	to	to	TO
cord-297078-pxggjaby	136	9	insert	insert	VB
cord-297078-pxggjaby	136	10	its	-PRON-	PRP$
cord-297078-pxggjaby	136	11	b	b	NN
cord-297078-pxggjaby	136	12	-	-	HYPH
cord-297078-pxggjaby	136	13	ribbon	ribbon	NN
cord-297078-pxggjaby	136	14	domain	domain	NN
cord-297078-pxggjaby	136	15	III	III	NNP
cord-297078-pxggjaby	136	16	via	via	IN
cord-297078-pxggjaby	136	17	a	a	DT
cord-297078-pxggjaby	136	18	pore	pore	NN
cord-297078-pxggjaby	136	19	into	into	IN
cord-297078-pxggjaby	136	20	the	the	DT
cord-297078-pxggjaby	136	21	active	active	JJ
cord-297078-pxggjaby	136	22	site	site	NN
cord-297078-pxggjaby	136	23	.	.	.
cord-297078-pxggjaby	137	1	Two	two	CD
cord-297078-pxggjaby	137	2	acidic	acidic	JJ
cord-297078-pxggjaby	137	3	residues	residue	NNS
cord-297078-pxggjaby	137	4	at	at	IN
cord-297078-pxggjaby	137	5	the	the	DT
cord-297078-pxggjaby	137	6	tip	tip	NN
cord-297078-pxggjaby	137	7	of	of	IN
cord-297078-pxggjaby	137	8	a	a	DT
cord-297078-pxggjaby	137	9	loop	loop	NN
cord-297078-pxggjaby	137	10	in	in	IN
cord-297078-pxggjaby	137	11	domain	domain	NN
cord-297078-pxggjaby	137	12	III	III	NNP
cord-297078-pxggjaby	137	13	are	be	VBP
cord-297078-pxggjaby	137	14	presented	present	VBN
cord-297078-pxggjaby	137	15	to	to	IN
cord-297078-pxggjaby	137	16	the	the	DT
cord-297078-pxggjaby	137	17	active	active	JJ
cord-297078-pxggjaby	137	18	site	site	NN
cord-297078-pxggjaby	137	19	adjacent	adjacent	JJ
cord-297078-pxggjaby	137	20	to	to	IN
cord-297078-pxggjaby	137	21	the	the	DT
cord-297078-pxggjaby	137	22	tightly	tightly	RB
cord-297078-pxggjaby	137	23	bound	bind	VBN
cord-297078-pxggjaby	137	24	metal	metal	NN
cord-297078-pxggjaby	137	25	ion	ion	NN
cord-297078-pxggjaby	137	26	involved	involve	VBN
cord-297078-pxggjaby	137	27	in	in	IN
cord-297078-pxggjaby	137	28	elongation	elongation	NN
cord-297078-pxggjaby	137	29	(	(	-LRB-
cord-297078-pxggjaby	137	30	fig	fig	NN
cord-297078-pxggjaby	137	31	.	.	.
cord-297078-pxggjaby	138	1	3	3	LS
cord-297078-pxggjaby	138	2	,	,	,
cord-297078-pxggjaby	138	3	panels	panel	NNS
cord-297078-pxggjaby	138	4	b	b	NN
cord-297078-pxggjaby	138	5	and	and	CC
cord-297078-pxggjaby	138	6	d	d	LS
cord-297078-pxggjaby	138	7	)	)	-RRB-
cord-297078-pxggjaby	138	8	.	.	.
cord-297078-pxggjaby	139	1	In	in	IN
cord-297078-pxggjaby	139	2	a	a	DT
cord-297078-pxggjaby	139	3	parallel	parallel	JJ
cord-297078-pxggjaby	139	4	study	study	NN
cord-297078-pxggjaby	139	5	using	use	VBG
cord-297078-pxggjaby	139	6	electron	electron	NN
cord-297078-pxggjaby	139	7	microscopy	microscopy	NN
cord-297078-pxggjaby	139	8	(	(	-LRB-
cord-297078-pxggjaby	139	9	EM	EM	NNP
cord-297078-pxggjaby	139	10	)	)	-RRB-
cord-297078-pxggjaby	139	11	at	at	IN
cord-297078-pxggjaby	139	12	15	15	CD
cord-297078-pxggjaby	139	13	Å	å	NN
cord-297078-pxggjaby	139	14	resolution	resolution	NN
cord-297078-pxggjaby	139	15	(	(	-LRB-
cord-297078-pxggjaby	139	16	Opalka	Opalka	NNP
cord-297078-pxggjaby	139	17	et	et	NNP
cord-297078-pxggjaby	139	18	al	al	NNP
cord-297078-pxggjaby	139	19	.	.	NNP
cord-297078-pxggjaby	139	20	2003	2003	CD
cord-297078-pxggjaby	139	21	)	)	-RRB-
cord-297078-pxggjaby	139	22	,	,	,
cord-297078-pxggjaby	139	23	the	the	DT
cord-297078-pxggjaby	139	24	prokaryotic	prokaryotic	JJ
cord-297078-pxggjaby	139	25	elongation	elongation	NN
cord-297078-pxggjaby	139	26	factor	factor	NN
cord-297078-pxggjaby	139	27	GreB	GreB	NNP
cord-297078-pxggjaby	139	28	was	be	VBD
cord-297078-pxggjaby	139	29	bound	bind	VBN
cord-297078-pxggjaby	139	30	to	to	IN
cord-297078-pxggjaby	139	31	E.	E.	NNP
cord-297078-pxggjaby	139	32	coli	coli	NNS
cord-297078-pxggjaby	139	33	RNAP	RNAP	NNP
cord-297078-pxggjaby	139	34	.	.	.
cord-297078-pxggjaby	140	1	GreB	GreB	NNP
cord-297078-pxggjaby	140	2	inserts	insert	VBZ
cord-297078-pxggjaby	140	3	a	a	DT
cord-297078-pxggjaby	140	4	completely	completely	RB
cord-297078-pxggjaby	140	5	a	a	DT
cord-297078-pxggjaby	140	6	-	-	HYPH
cord-297078-pxggjaby	140	7	helical	helical	JJ
cord-297078-pxggjaby	140	8	domain	domain	NN
cord-297078-pxggjaby	140	9	into	into	IN
cord-297078-pxggjaby	140	10	the	the	DT
cord-297078-pxggjaby	140	11	RNAP	RNAP	NNP
cord-297078-pxggjaby	140	12	active	active	JJ
cord-297078-pxggjaby	140	13	site	site	NN
cord-297078-pxggjaby	140	14	.	.	.
cord-297078-pxggjaby	141	1	Despite	despite	IN
cord-297078-pxggjaby	141	2	having	have	VBG
cord-297078-pxggjaby	141	3	no	no	DT
cord-297078-pxggjaby	141	4	structural	structural	JJ
cord-297078-pxggjaby	141	5	homology	homology	NN
cord-297078-pxggjaby	141	6	whatsoever	whatsoever	RB
cord-297078-pxggjaby	141	7	to	to	IN
cord-297078-pxggjaby	141	8	TFIIS	TFIIS	NNP
cord-297078-pxggjaby	141	9	,	,	,
cord-297078-pxggjaby	141	10	it	-PRON-	PRP
cord-297078-pxggjaby	141	11	nevertheless	nevertheless	RB
cord-297078-pxggjaby	141	12	also	also	RB
cord-297078-pxggjaby	141	13	appears	appear	VBZ
cord-297078-pxggjaby	141	14	to	to	TO
cord-297078-pxggjaby	141	15	present	present	VB
cord-297078-pxggjaby	141	16	two	two	CD
cord-297078-pxggjaby	141	17	completely	completely	RB
cord-297078-pxggjaby	141	18	conserved	conserved	JJ
cord-297078-pxggjaby	141	19	acidic	acidic	JJ
cord-297078-pxggjaby	141	20	residues	residue	NNS
cord-297078-pxggjaby	141	21	to	to	IN
cord-297078-pxggjaby	141	22	the	the	DT
cord-297078-pxggjaby	141	23	active	active	JJ
cord-297078-pxggjaby	141	24	site	site	NN
cord-297078-pxggjaby	141	25	near	near	IN
cord-297078-pxggjaby	141	26	the	the	DT
cord-297078-pxggjaby	141	27	metal	metal	NN
cord-297078-pxggjaby	141	28	ion	ion	NN
cord-297078-pxggjaby	141	29	(	(	-LRB-
cord-297078-pxggjaby	141	30	fig	fig	NN
cord-297078-pxggjaby	141	31	.	.	.
cord-297078-pxggjaby	141	32	3	3	CD
cord-297078-pxggjaby	141	33	,	,	,
cord-297078-pxggjaby	141	34	panels	panel	VBZ
cord-297078-pxggjaby	141	35	a	a	DT
cord-297078-pxggjaby	141	36	and	and	CC
cord-297078-pxggjaby	141	37	c	c	NN
cord-297078-pxggjaby	141	38	)	)	-RRB-
cord-297078-pxggjaby	141	39	.	.	.
cord-297078-pxggjaby	142	1	In	in	IN
cord-297078-pxggjaby	142	2	both	both	DT
cord-297078-pxggjaby	142	3	cases	case	NNS
cord-297078-pxggjaby	142	4	,	,	,
cord-297078-pxggjaby	142	5	the	the	DT
cord-297078-pxggjaby	142	6	acidic	acidic	JJ
cord-297078-pxggjaby	142	7	residues	residue	NNS
cord-297078-pxggjaby	142	8	are	be	VBP
cord-297078-pxggjaby	142	9	proposed	propose	VBN
cord-297078-pxggjaby	142	10	to	to	TO
cord-297078-pxggjaby	142	11	position	position	VB
cord-297078-pxggjaby	142	12	a	a	DT
cord-297078-pxggjaby	142	13	second	second	JJ
cord-297078-pxggjaby	142	14	metal	metal	NN
cord-297078-pxggjaby	142	15	ion	ion	NN
cord-297078-pxggjaby	142	16	and	and	CC
cord-297078-pxggjaby	142	17	water	water	NN
cord-297078-pxggjaby	142	18	molecule	molecule	NN
cord-297078-pxggjaby	142	19	for	for	IN
cord-297078-pxggjaby	142	20	hydrolytic	hydrolytic	JJ
cord-297078-pxggjaby	142	21	RNA	RNA	NNP
cord-297078-pxggjaby	142	22	cleavage	cleavage	NN
cord-297078-pxggjaby	142	23	(	(	-LRB-
cord-297078-pxggjaby	142	24	fig	fig	NN
cord-297078-pxggjaby	142	25	.	.	NNP
cord-297078-pxggjaby	142	26	2	2	LS
cord-297078-pxggjaby	142	27	)	)	-RRB-
cord-297078-pxggjaby	142	28	as	as	IN
cord-297078-pxggjaby	142	29	proposed	propose	VBN
cord-297078-pxggjaby	142	30	by	by	IN
cord-297078-pxggjaby	142	31	.	.	.
cord-297078-pxggjaby	143	1	However	however	RB
cord-297078-pxggjaby	143	2	,	,	,
cord-297078-pxggjaby	143	3	the	the	DT
cord-297078-pxggjaby	143	4	resolution	resolution	NN
cord-297078-pxggjaby	143	5	of	of	IN
cord-297078-pxggjaby	143	6	the	the	DT
cord-297078-pxggjaby	143	7	EM	EM	NNP
cord-297078-pxggjaby	143	8	study	study	NN
cord-297078-pxggjaby	143	9	did	do	VBD
cord-297078-pxggjaby	143	10	not	not	RB
cord-297078-pxggjaby	143	11	allow	allow	VB
cord-297078-pxggjaby	143	12	the	the	DT
cord-297078-pxggjaby	143	13	acidic	acidic	JJ
cord-297078-pxggjaby	143	14	residues	residue	NNS
cord-297078-pxggjaby	143	15	to	to	TO
cord-297078-pxggjaby	143	16	be	be	VB
cord-297078-pxggjaby	143	17	accurately	accurately	RB
cord-297078-pxggjaby	143	18	placed	place	VBN
cord-297078-pxggjaby	143	19	in	in	IN
cord-297078-pxggjaby	143	20	the	the	DT
cord-297078-pxggjaby	143	21	active	active	JJ
cord-297078-pxggjaby	143	22	site	site	NN
cord-297078-pxggjaby	143	23	.	.	.
cord-297078-pxggjaby	144	1	Sosunova	Sosunova	NNP
cord-297078-pxggjaby	144	2	et	et	NNP
cord-297078-pxggjaby	144	3	al	al	NNP
cord-297078-pxggjaby	144	4	.	.	.
cord-297078-pxggjaby	145	1	(	(	-LRB-
cord-297078-pxggjaby	145	2	2003	2003	CD
cord-297078-pxggjaby	145	3	)	)	-RRB-
cord-297078-pxggjaby	145	4	nicely	nicely	RB
cord-297078-pxggjaby	145	5	complemented	complement	VBD
cord-297078-pxggjaby	145	6	this	this	DT
cord-297078-pxggjaby	145	7	work	work	NN
cord-297078-pxggjaby	145	8	using	use	VBG
cord-297078-pxggjaby	145	9	mutation	mutation	NN
cord-297078-pxggjaby	145	10	,	,	,
cord-297078-pxggjaby	145	11	crosslinking	crosslinking	NN
cord-297078-pxggjaby	145	12	,	,	,
cord-297078-pxggjaby	145	13	and	and	CC
cord-297078-pxggjaby	145	14	modeling	modeling	NN
cord-297078-pxggjaby	145	15	,	,	,
cord-297078-pxggjaby	145	16	locating	locate	VBG
cord-297078-pxggjaby	145	17	the	the	DT
cord-297078-pxggjaby	145	18	acidic	acidic	JJ
cord-297078-pxggjaby	145	19	residues	residue	NNS
cord-297078-pxggjaby	145	20	unambiguously	unambiguously	RB
cord-297078-pxggjaby	145	21	in	in	IN
cord-297078-pxggjaby	145	22	the	the	DT
cord-297078-pxggjaby	145	23	active	active	JJ
cord-297078-pxggjaby	145	24	site	site	NN
cord-297078-pxggjaby	145	25	and	and	CC
cord-297078-pxggjaby	145	26	confirming	confirm	VBG
cord-297078-pxggjaby	145	27	that	that	IN
cord-297078-pxggjaby	145	28	GreB	GreB	NNP
cord-297078-pxggjaby	145	29	does	do	VBZ
cord-297078-pxggjaby	145	30	not	not	RB
cord-297078-pxggjaby	145	31	work	work	VB
cord-297078-pxggjaby	145	32	allosterically	allosterically	RB
cord-297078-pxggjaby	145	33	but	but	CC
cord-297078-pxggjaby	145	34	by	by	IN
cord-297078-pxggjaby	145	35	direct	direct	JJ
cord-297078-pxggjaby	145	36	recruitment	recruitment	NN
cord-297078-pxggjaby	145	37	of	of	IN
cord-297078-pxggjaby	145	38	a	a	DT
cord-297078-pxggjaby	145	39	metal	metal	NN
cord-297078-pxggjaby	145	40	ion	ion	NN
cord-297078-pxggjaby	145	41	.	.	.
cord-297078-pxggjaby	146	1	In	in	IN
cord-297078-pxggjaby	146	2	summary	summary	NN
cord-297078-pxggjaby	146	3	,	,	,
cord-297078-pxggjaby	146	4	the	the	DT
cord-297078-pxggjaby	146	5	available	available	JJ
cord-297078-pxggjaby	146	6	data	datum	NNS
cord-297078-pxggjaby	146	7	suggest	suggest	VBP
cord-297078-pxggjaby	146	8	that	that	IN
cord-297078-pxggjaby	146	9	this	this	DT
cord-297078-pxggjaby	146	10	form	form	NN
cord-297078-pxggjaby	146	11	of	of	IN
cord-297078-pxggjaby	146	12	nascent	nascent	JJ
cord-297078-pxggjaby	146	13	transcript	transcript	NN
cord-297078-pxggjaby	146	14	repair	repair	NN
cord-297078-pxggjaby	146	15	is	be	VBZ
cord-297078-pxggjaby	146	16	ubiquitous	ubiquitous	JJ
cord-297078-pxggjaby	146	17	,	,	,
cord-297078-pxggjaby	146	18	providing	provide	VBG
cord-297078-pxggjaby	146	19	not	not	RB
cord-297078-pxggjaby	146	20	only	only	RB
cord-297078-pxggjaby	146	21	a	a	DT
cord-297078-pxggjaby	146	22	means	means	NN
cord-297078-pxggjaby	146	23	of	of	IN
cord-297078-pxggjaby	146	24	reading	read	VBG
cord-297078-pxggjaby	146	25	through	through	IN
cord-297078-pxggjaby	146	26	arrest	arrest	NN
cord-297078-pxggjaby	146	27	sites	site	NNS
cord-297078-pxggjaby	146	28	,	,	,
cord-297078-pxggjaby	146	29	but	but	CC
cord-297078-pxggjaby	146	30	also	also	RB
cord-297078-pxggjaby	146	31	of	of	IN
cord-297078-pxggjaby	146	32	removing	remove	VBG
cord-297078-pxggjaby	146	33	misincorporated	misincorporate	VBN
cord-297078-pxggjaby	146	34	bases	basis	NNS
cord-297078-pxggjaby	146	35	during	during	IN
cord-297078-pxggjaby	146	36	transcription	transcription	NN
cord-297078-pxggjaby	146	37	.	.	.
cord-297078-pxggjaby	147	1	Moreover	moreover	RB
cord-297078-pxggjaby	147	2	,	,	,
cord-297078-pxggjaby	147	3	recent	recent	JJ
cord-297078-pxggjaby	147	4	data	datum	NNS
cord-297078-pxggjaby	147	5	strengthen	strengthen	VBP
cord-297078-pxggjaby	147	6	the	the	DT
cord-297078-pxggjaby	147	7	concept	concept	NN
cord-297078-pxggjaby	147	8	of	of	IN
cord-297078-pxggjaby	147	9	an	an	DT
cord-297078-pxggjaby	147	10	intrinsic	intrinsic	JJ
cord-297078-pxggjaby	147	11	unified	unified	JJ
cord-297078-pxggjaby	147	12	two	two	CD
cord-297078-pxggjaby	147	13	-	-	HYPH
cord-297078-pxggjaby	147	14	metal	metal	NN
cord-297078-pxggjaby	147	15	mechanism	mechanism	NN
cord-297078-pxggjaby	147	16	for	for	IN
cord-297078-pxggjaby	147	17	synthesis	synthesis	NN
cord-297078-pxggjaby	147	18	and	and	CC
cord-297078-pxggjaby	147	19	repair	repair	NN
cord-297078-pxggjaby	147	20	in	in	IN
cord-297078-pxggjaby	147	21	both	both	CC
cord-297078-pxggjaby	147	22	DNA	DNA	NNP
cord-297078-pxggjaby	147	23	and	and	CC
cord-297078-pxggjaby	147	24	RNA	RNA	NNP
cord-297078-pxggjaby	147	25	polymerases	polymerase	NNS
cord-297078-pxggjaby	147	26	,	,	,
cord-297078-pxggjaby	147	27	greatly	greatly	RB
cord-297078-pxggjaby	147	28	stimulated	stimulate	VBN
cord-297078-pxggjaby	147	29	by	by	IN
cord-297078-pxggjaby	147	30	external	external	JJ
cord-297078-pxggjaby	147	31	factors	factor	NNS
cord-297078-pxggjaby	147	32	in	in	IN
cord-297078-pxggjaby	147	33	the	the	DT
cord-297078-pxggjaby	147	34	latter	latter	JJ
cord-297078-pxggjaby	147	35	case	case	NN
cord-297078-pxggjaby	147	36	.	.	.
cord-297078-pxggjaby	148	1	That	that	DT
cord-297078-pxggjaby	148	2	read	read	NN
cord-297078-pxggjaby	148	3	-	-	HYPH
cord-297078-pxggjaby	148	4	through	through	NN
cord-297078-pxggjaby	148	5	and	and	CC
cord-297078-pxggjaby	148	6	repair	repair	NN
cord-297078-pxggjaby	148	7	is	be	VBZ
cord-297078-pxggjaby	148	8	distinct	distinct	JJ
cord-297078-pxggjaby	148	9	from	from	IN
cord-297078-pxggjaby	148	10	RNA	RNA	NNP
cord-297078-pxggjaby	148	11	surveillance	surveillance	NN
cord-297078-pxggjaby	148	12	demonstrates	demonstrate	VBZ
cord-297078-pxggjaby	148	13	that	that	IN
cord-297078-pxggjaby	148	14	quality	quality	NN
cord-297078-pxggjaby	148	15	control	control	NN
cord-297078-pxggjaby	148	16	of	of	IN
cord-297078-pxggjaby	148	17	RNA	RNA	NNP
cord-297078-pxggjaby	148	18	synthesis	synthesis	NN
cord-297078-pxggjaby	148	19	is	be	VBZ
cord-297078-pxggjaby	148	20	not	not	RB
cord-297078-pxggjaby	148	21	limited	limit	VBN
cord-297078-pxggjaby	148	22	to	to	IN
cord-297078-pxggjaby	148	23	degradative	degradative	JJ
cord-297078-pxggjaby	148	24	pathways	pathway	NNS
cord-297078-pxggjaby	148	25	.	.	.
cord-297078-pxggjaby	149	1	We	-PRON-	PRP
cord-297078-pxggjaby	149	2	will	will	MD
cord-297078-pxggjaby	149	3	next	next	RB
cord-297078-pxggjaby	149	4	consider	consider	VB
cord-297078-pxggjaby	149	5	the	the	DT
cord-297078-pxggjaby	149	6	implications	implication	NNS
cord-297078-pxggjaby	149	7	of	of	IN
cord-297078-pxggjaby	149	8	this	this	DT
cord-297078-pxggjaby	149	9	process	process	NN
cord-297078-pxggjaby	149	10	for	for	IN
cord-297078-pxggjaby	149	11	the	the	DT
cord-297078-pxggjaby	149	12	timing	timing	NN
cord-297078-pxggjaby	149	13	of	of	IN
cord-297078-pxggjaby	149	14	the	the	DT
cord-297078-pxggjaby	149	15	RNA	RNA	NNP
cord-297078-pxggjaby	149	16	to	to	IN
cord-297078-pxggjaby	149	17	DNA	dna	NN
cord-297078-pxggjaby	149	18	transition	transition	NN
cord-297078-pxggjaby	149	19	.	.	.
cord-297078-pxggjaby	150	1	(	(	-LRB-
cord-297078-pxggjaby	150	2	Opalka	Opalka	NNP
cord-297078-pxggjaby	150	3	et	et	NNP
cord-297078-pxggjaby	150	4	al	al	NNP
cord-297078-pxggjaby	150	5	.	.	NNP
cord-297078-pxggjaby	150	6	2003	2003	CD
cord-297078-pxggjaby	150	7	)	)	-RRB-
cord-297078-pxggjaby	150	8	.	.	.
cord-297078-pxggjaby	151	1	The	the	DT
cord-297078-pxggjaby	151	2	b	b	NN
cord-297078-pxggjaby	151	3	and	and	CC
cord-297078-pxggjaby	151	4	b	b	NN
cord-297078-pxggjaby	151	5	#	#	$
cord-297078-pxggjaby	151	6	subunits	subunit	NNS
cord-297078-pxggjaby	151	7	are	be	VBP
cord-297078-pxggjaby	151	8	colored	color	VBN
cord-297078-pxggjaby	151	9	cyan	cyan	NN
cord-297078-pxggjaby	151	10	and	and	CC
cord-297078-pxggjaby	151	11	blue	blue	JJ
cord-297078-pxggjaby	151	12	,	,	,
cord-297078-pxggjaby	151	13	respectively	respectively	RB
cord-297078-pxggjaby	151	14	,	,	,
cord-297078-pxggjaby	151	15	while	while	IN
cord-297078-pxggjaby	151	16	the	the	DT
cord-297078-pxggjaby	151	17	other	other	JJ
cord-297078-pxggjaby	151	18	subunits	subunit	NNS
cord-297078-pxggjaby	151	19	are	be	VBP
cord-297078-pxggjaby	151	20	colored	color	VBN
cord-297078-pxggjaby	151	21	gray	gray	NN
cord-297078-pxggjaby	151	22	for	for	IN
cord-297078-pxggjaby	151	23	clarity	clarity	NN
cord-297078-pxggjaby	151	24	.	.	.
cord-297078-pxggjaby	152	1	The	the	DT
cord-297078-pxggjaby	152	2	a	a	DT
cord-297078-pxggjaby	152	3	-	-	HYPH
cord-297078-pxggjaby	152	4	helices	helix	NNS
cord-297078-pxggjaby	152	5	are	be	VBP
cord-297078-pxggjaby	152	6	drawn	draw	VBN
cord-297078-pxggjaby	152	7	as	as	IN
cord-297078-pxggjaby	152	8	cylinders	cylinder	NNS
cord-297078-pxggjaby	152	9	.	.	.
cord-297078-pxggjaby	153	1	GreB	GreB	NNP
cord-297078-pxggjaby	153	2	is	be	VBZ
cord-297078-pxggjaby	153	3	colored	color	VBN
cord-297078-pxggjaby	153	4	red	red	JJ
cord-297078-pxggjaby	153	5	-	-	HYPH
cord-297078-pxggjaby	153	6	a	a	NN
cord-297078-pxggjaby	153	7	-	-	HYPH
cord-297078-pxggjaby	153	8	helices	helix	NNS
cord-297078-pxggjaby	153	9	are	be	VBP
cord-297078-pxggjaby	153	10	drawn	draw	VBN
cord-297078-pxggjaby	153	11	as	as	IN
cord-297078-pxggjaby	153	12	ribbons	ribbon	NNS
cord-297078-pxggjaby	153	13	for	for	IN
cord-297078-pxggjaby	153	14	contrast	contrast	NN
cord-297078-pxggjaby	153	15	with	with	IN
cord-297078-pxggjaby	153	16	RNAP	RNAP	NNP
cord-297078-pxggjaby	153	17	.	.	.
cord-297078-pxggjaby	154	1	(	(	-LRB-
cord-297078-pxggjaby	154	2	b	b	NN
cord-297078-pxggjaby	154	3	)	)	-RRB-
cord-297078-pxggjaby	155	1	The	the	DT
cord-297078-pxggjaby	155	2	eukaryotic	eukaryotic	JJ
cord-297078-pxggjaby	155	3	system	system	NN
cord-297078-pxggjaby	155	4	as	as	IN
cord-297078-pxggjaby	155	5	represented	represent	VBN
cord-297078-pxggjaby	155	6	by	by	IN
cord-297078-pxggjaby	155	7	the	the	DT
cord-297078-pxggjaby	155	8	3.8-Å	3.8-å	CD
cord-297078-pxggjaby	155	9	crystal	crystal	NN
cord-297078-pxggjaby	155	10	structure	structure	NN
cord-297078-pxggjaby	155	11	of	of	IN
cord-297078-pxggjaby	155	12	yeast	yeast	NN
cord-297078-pxggjaby	155	13	PolII	polii	NN
cord-297078-pxggjaby	155	14	in	in	IN
cord-297078-pxggjaby	155	15	complex	complex	NN
cord-297078-pxggjaby	155	16	with	with	IN
cord-297078-pxggjaby	155	17	TFIIS	TFIIS	NNP
cord-297078-pxggjaby	155	18	,	,	,
cord-297078-pxggjaby	155	19	PDB	PDB	NNP
cord-297078-pxggjaby	155	20	(	(	-LRB-
cord-297078-pxggjaby	155	21	Protein	Protein	NNP
cord-297078-pxggjaby	155	22	Data	Data	NNP
cord-297078-pxggjaby	155	23	Bank	Bank	NNP
cord-297078-pxggjaby	155	24	)	)	-RRB-
cord-297078-pxggjaby	155	25	code	code	NN
cord-297078-pxggjaby	155	26	1Y1V	1y1v	CD
cord-297078-pxggjaby	156	1	(	(	-LRB-
cord-297078-pxggjaby	156	2	Kettenberger	Kettenberger	NNP
cord-297078-pxggjaby	156	3	,	,	,
cord-297078-pxggjaby	156	4	Armache	Armache	NNP
cord-297078-pxggjaby	156	5	,	,	,
cord-297078-pxggjaby	156	6	and	and	CC
cord-297078-pxggjaby	156	7	Cramer	Cramer	NNP
cord-297078-pxggjaby	156	8	2003	2003	CD
cord-297078-pxggjaby	156	9	,	,	,
cord-297078-pxggjaby	156	10	2004	2004	CD
cord-297078-pxggjaby	156	11	)	)	-RRB-
cord-297078-pxggjaby	156	12	.	.	.
cord-297078-pxggjaby	157	1	The	the	DT
cord-297078-pxggjaby	157	2	Rpb2	Rpb2	NNP
cord-297078-pxggjaby	157	3	and	and	CC
cord-297078-pxggjaby	157	4	Rpb1	rpb1	JJ
cord-297078-pxggjaby	157	5	subunits	subunit	NNS
cord-297078-pxggjaby	157	6	are	be	VBP
cord-297078-pxggjaby	157	7	colored	color	VBN
cord-297078-pxggjaby	157	8	cyan	cyan	NN
cord-297078-pxggjaby	157	9	and	and	CC
cord-297078-pxggjaby	157	10	blue	blue	JJ
cord-297078-pxggjaby	157	11	,	,	,
cord-297078-pxggjaby	157	12	respectively	respectively	RB
cord-297078-pxggjaby	157	13	.	.	.
cord-297078-pxggjaby	158	1	TFIIS	TFIIS	NNP
cord-297078-pxggjaby	158	2	is	be	VBZ
cord-297078-pxggjaby	158	3	colored	color	VBN
cord-297078-pxggjaby	158	4	red	red	JJ
cord-297078-pxggjaby	158	5	.	.	.
cord-297078-pxggjaby	159	1	The	the	DT
cord-297078-pxggjaby	159	2	orientations	orientation	NNS
cord-297078-pxggjaby	159	3	in	in	IN
cord-297078-pxggjaby	159	4	panels	panel	NNS
cord-297078-pxggjaby	159	5	(	(	-LRB-
cord-297078-pxggjaby	159	6	a	a	LS
cord-297078-pxggjaby	159	7	)	)	-RRB-
cord-297078-pxggjaby	159	8	and	and	CC
cord-297078-pxggjaby	159	9	(	(	-LRB-
cord-297078-pxggjaby	159	10	b	b	NN
cord-297078-pxggjaby	159	11	)	)	-RRB-
cord-297078-pxggjaby	159	12	are	be	VBP
cord-297078-pxggjaby	159	13	almost	almost	RB
cord-297078-pxggjaby	159	14	identical	identical	JJ
cord-297078-pxggjaby	159	15	.	.	.
cord-297078-pxggjaby	160	1	(	(	-LRB-
cord-297078-pxggjaby	160	2	c	c	NN
cord-297078-pxggjaby	160	3	)	)	-RRB-
cord-297078-pxggjaby	161	1	Detailed	detailed	JJ
cord-297078-pxggjaby	161	2	view	view	NN
cord-297078-pxggjaby	161	3	of	of	IN
cord-297078-pxggjaby	161	4	the	the	DT
cord-297078-pxggjaby	161	5	active	active	JJ
cord-297078-pxggjaby	161	6	site	site	NN
cord-297078-pxggjaby	161	7	of	of	IN
cord-297078-pxggjaby	161	8	the	the	DT
cord-297078-pxggjaby	161	9	E.	E.	NNP
cord-297078-pxggjaby	161	10	coli	coli	NNS
cord-297078-pxggjaby	161	11	complex	complex	JJ
cord-297078-pxggjaby	161	12	.	.	.
cord-297078-pxggjaby	162	1	The	the	DT
cord-297078-pxggjaby	162	2	side	side	NN
cord-297078-pxggjaby	162	3	-	-	HYPH
cord-297078-pxggjaby	162	4	chain	chain	NN
cord-297078-pxggjaby	162	5	positions	position	NNS
cord-297078-pxggjaby	162	6	(	(	-LRB-
cord-297078-pxggjaby	162	7	from	from	IN
cord-297078-pxggjaby	162	8	coordinates	coordinate	NNS
cord-297078-pxggjaby	162	9	kindly	kindly	RB
cord-297078-pxggjaby	162	10	provided	provide	VBN
cord-297078-pxggjaby	162	11	by	by	IN
cord-297078-pxggjaby	162	12	Seth	Seth	NNP
cord-297078-pxggjaby	162	13	Darst	Darst	NNP
cord-297078-pxggjaby	162	14	)	)	-RRB-
cord-297078-pxggjaby	162	15	should	should	MD
cord-297078-pxggjaby	162	16	not	not	RB
cord-297078-pxggjaby	162	17	be	be	VB
cord-297078-pxggjaby	162	18	interpreted	interpret	VBN
cord-297078-pxggjaby	162	19	literally	literally	RB
cord-297078-pxggjaby	162	20	due	due	JJ
cord-297078-pxggjaby	162	21	to	to	IN
cord-297078-pxggjaby	162	22	the	the	DT
cord-297078-pxggjaby	162	23	low	low	JJ
cord-297078-pxggjaby	162	24	resolution	resolution	NN
cord-297078-pxggjaby	162	25	of	of	IN
cord-297078-pxggjaby	162	26	the	the	DT
cord-297078-pxggjaby	162	27	EM	EM	NNP
cord-297078-pxggjaby	162	28	structure	structure	NN
cord-297078-pxggjaby	162	29	,	,	,
cord-297078-pxggjaby	162	30	which	which	WDT
cord-297078-pxggjaby	162	31	is	be	VBZ
cord-297078-pxggjaby	162	32	nevertheless	nevertheless	RB
cord-297078-pxggjaby	162	33	the	the	DT
cord-297078-pxggjaby	162	34	best	well	RBS
cord-297078-pxggjaby	162	35	available	available	JJ
cord-297078-pxggjaby	162	36	experimentally	experimentally	RB
cord-297078-pxggjaby	162	37	derived	derive	VBN
cord-297078-pxggjaby	162	38	model	model	NN
cord-297078-pxggjaby	162	39	.	.	.
cord-297078-pxggjaby	163	1	(	(	-LRB-
cord-297078-pxggjaby	163	2	d	d	NN
cord-297078-pxggjaby	163	3	)	)	-RRB-
cord-297078-pxggjaby	164	1	Detailed	detailed	JJ
cord-297078-pxggjaby	164	2	view	view	NN
cord-297078-pxggjaby	164	3	of	of	IN
cord-297078-pxggjaby	164	4	the	the	DT
cord-297078-pxggjaby	164	5	yeast	yeast	NN
cord-297078-pxggjaby	164	6	PolII	polii	NN
cord-297078-pxggjaby	164	7	active	active	JJ
cord-297078-pxggjaby	164	8	site	site	NN
cord-297078-pxggjaby	164	9	.	.	.
cord-297078-pxggjaby	165	1	In	in	IN
cord-297078-pxggjaby	165	2	panels	panel	NNS
cord-297078-pxggjaby	165	3	(	(	-LRB-
cord-297078-pxggjaby	165	4	c	c	NN
cord-297078-pxggjaby	165	5	)	)	-RRB-
cord-297078-pxggjaby	165	6	and	and	CC
cord-297078-pxggjaby	165	7	(	(	-LRB-
cord-297078-pxggjaby	165	8	d	d	LS
cord-297078-pxggjaby	165	9	)	)	-RRB-
cord-297078-pxggjaby	165	10	the	the	DT
cord-297078-pxggjaby	165	11	two	two	CD
cord-297078-pxggjaby	165	12	Mg	Mg	NNP
cord-297078-pxggjaby	165	13	21	21	CD
cord-297078-pxggjaby	165	14	ions	ion	NNS
cord-297078-pxggjaby	165	15	proposed	propose	VBD
cord-297078-pxggjaby	165	16	to	to	TO
cord-297078-pxggjaby	165	17	be	be	VB
cord-297078-pxggjaby	165	18	part	part	NN
cord-297078-pxggjaby	165	19	of	of	IN
cord-297078-pxggjaby	165	20	the	the	DT
cord-297078-pxggjaby	165	21	two	two	CD
cord-297078-pxggjaby	165	22	-	-	HYPH
cord-297078-pxggjaby	165	23	metal	metal	NN
cord-297078-pxggjaby	165	24	ion	ion	NN
cord-297078-pxggjaby	165	25	mechanism	mechanism	NN
cord-297078-pxggjaby	165	26	for	for	IN
cord-297078-pxggjaby	165	27	RNA	RNA	NNP
cord-297078-pxggjaby	165	28	synthesis	synthesis	NN
cord-297078-pxggjaby	165	29	and	and	CC
cord-297078-pxggjaby	165	30	editing	editing	NN
cord-297078-pxggjaby	165	31	are	be	VBP
cord-297078-pxggjaby	165	32	shown	show	VBN
cord-297078-pxggjaby	165	33	as	as	IN
cord-297078-pxggjaby	165	34	gold	gold	NN
cord-297078-pxggjaby	165	35	spheres	sphere	NNS
cord-297078-pxggjaby	165	36	.	.	.
cord-297078-pxggjaby	166	1	Since	since	IN
cord-297078-pxggjaby	166	2	Mg	Mg	NNP
cord-297078-pxggjaby	166	3	21	21	CD
cord-297078-pxggjaby	166	4	ion	ion	NN
cord-297078-pxggjaby	166	5	II	II	NNP
cord-297078-pxggjaby	166	6	is	be	VBZ
cord-297078-pxggjaby	166	7	not	not	RB
cord-297078-pxggjaby	166	8	deposited	deposit	VBN
cord-297078-pxggjaby	166	9	in	in	IN
cord-297078-pxggjaby	166	10	any	any	DT
cord-297078-pxggjaby	166	11	PDB	PDB	NNP
cord-297078-pxggjaby	166	12	file	file	NN
cord-297078-pxggjaby	166	13	,	,	,
cord-297078-pxggjaby	166	14	it	-PRON-	PRP
cord-297078-pxggjaby	166	15	was	be	VBD
cord-297078-pxggjaby	166	16	modeled	model	VBN
cord-297078-pxggjaby	166	17	by	by	IN
cord-297078-pxggjaby	166	18	hand	hand	NN
cord-297078-pxggjaby	166	19	into	into	IN
cord-297078-pxggjaby	166	20	the	the	DT
cord-297078-pxggjaby	166	21	coordinates	coordinate	NNS
cord-297078-pxggjaby	166	22	of	of	IN
cord-297078-pxggjaby	166	23	RNAP	RNAP	NNP
cord-297078-pxggjaby	166	24	/	/	SYM
cord-297078-pxggjaby	166	25	GreB	GreB	NNP
cord-297078-pxggjaby	166	26	and	and	CC
cord-297078-pxggjaby	166	27	generated	generate	VBN
cord-297078-pxggjaby	166	28	in	in	IN
cord-297078-pxggjaby	166	29	the	the	DT
cord-297078-pxggjaby	166	30	yeast	yeast	NN
cord-297078-pxggjaby	166	31	PolII	polii	NN
cord-297078-pxggjaby	166	32	structure	structure	NN
cord-297078-pxggjaby	166	33	by	by	IN
cord-297078-pxggjaby	166	34	superposition	superposition	NN
cord-297078-pxggjaby	166	35	of	of	IN
cord-297078-pxggjaby	166	36	the	the	DT
cord-297078-pxggjaby	166	37	Ca	Ca	NNP
cord-297078-pxggjaby	166	38	atoms	atom	NNS
cord-297078-pxggjaby	166	39	of	of	IN
cord-297078-pxggjaby	166	40	the	the	DT
cord-297078-pxggjaby	166	41	coordinating	coordinate	VBG
cord-297078-pxggjaby	166	42	residues	residue	NNS
cord-297078-pxggjaby	166	43	of	of	IN
cord-297078-pxggjaby	166	44	RNAP	RNAP	NNP
cord-297078-pxggjaby	166	45	and	and	CC
cord-297078-pxggjaby	166	46	PolII	PolII	NNP
cord-297078-pxggjaby	166	47	.	.	.
cord-297078-pxggjaby	167	1	Its	-PRON-	PRP$
cord-297078-pxggjaby	167	2	position	position	NN
cord-297078-pxggjaby	167	3	in	in	IN
cord-297078-pxggjaby	167	4	this	this	DT
cord-297078-pxggjaby	167	5	figure	figure	NN
cord-297078-pxggjaby	167	6	is	be	VBZ
cord-297078-pxggjaby	167	7	for	for	IN
cord-297078-pxggjaby	167	8	illustrative	illustrative	JJ
cord-297078-pxggjaby	167	9	purposes	purpose	NNS
cord-297078-pxggjaby	167	10	only	only	RB
cord-297078-pxggjaby	167	11	.	.	.
cord-297078-pxggjaby	168	1	Before	before	IN
cord-297078-pxggjaby	168	2	evaluating	evaluate	VBG
cord-297078-pxggjaby	168	3	the	the	DT
cord-297078-pxggjaby	168	4	possibility	possibility	NN
cord-297078-pxggjaby	168	5	that	that	IN
cord-297078-pxggjaby	168	6	LUCA	LUCA	NNP
cord-297078-pxggjaby	168	7	possessed	possess	VBD
cord-297078-pxggjaby	168	8	an	an	DT
cord-297078-pxggjaby	168	9	RNA	RNA	NNP
cord-297078-pxggjaby	168	10	genome	genome	NN
cord-297078-pxggjaby	168	11	,	,	,
cord-297078-pxggjaby	168	12	subject	subject	JJ
cord-297078-pxggjaby	168	13	to	to	IN
cord-297078-pxggjaby	168	14	proofreading	proofreading	NN
cord-297078-pxggjaby	168	15	and	and	CC
cord-297078-pxggjaby	168	16	repair	repair	NN
cord-297078-pxggjaby	168	17	,	,	,
cord-297078-pxggjaby	168	18	we	-PRON-	PRP
cord-297078-pxggjaby	168	19	first	first	RB
cord-297078-pxggjaby	168	20	review	review	VBP
cord-297078-pxggjaby	168	21	the	the	DT
cord-297078-pxggjaby	168	22	evidence	evidence	NN
cord-297078-pxggjaby	168	23	that	that	WDT
cord-297078-pxggjaby	168	24	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	168	25	RNA	RNA	NNP
cord-297078-pxggjaby	168	26	polymerases	polymerase	NNS
cord-297078-pxggjaby	168	27	and	and	CC
cord-297078-pxggjaby	168	28	the	the	DT
cord-297078-pxggjaby	168	29	repair	repair	NN
cord-297078-pxggjaby	168	30	capability	capability	NN
cord-297078-pxggjaby	168	31	date	date	NN
cord-297078-pxggjaby	168	32	back	back	RB
cord-297078-pxggjaby	168	33	to	to	IN
cord-297078-pxggjaby	168	34	LUCA	LUCA	NNP
cord-297078-pxggjaby	168	35	.	.	.
cord-297078-pxggjaby	169	1	There	there	EX
cord-297078-pxggjaby	169	2	are	be	VBP
cord-297078-pxggjaby	169	3	strong	strong	JJ
cord-297078-pxggjaby	169	4	lines	line	NNS
cord-297078-pxggjaby	169	5	of	of	IN
cord-297078-pxggjaby	169	6	evidence	evidence	NN
cord-297078-pxggjaby	169	7	that	that	WDT
cord-297078-pxggjaby	169	8	attest	attest	VBP
cord-297078-pxggjaby	169	9	to	to	IN
cord-297078-pxggjaby	169	10	LUCA	LUCA	NNP
cord-297078-pxggjaby	169	11	possessing	possess	VBG
cord-297078-pxggjaby	169	12	such	such	PDT
cord-297078-pxggjaby	169	13	an	an	DT
cord-297078-pxggjaby	169	14	RNA	RNA	NNP
cord-297078-pxggjaby	169	15	polymerase	polymerase	NN
cord-297078-pxggjaby	169	16	.	.	.
cord-297078-pxggjaby	170	1	Firstly	firstly	RB
cord-297078-pxggjaby	170	2	,	,	,
cord-297078-pxggjaby	170	3	archaeal	archaeal	JJ
cord-297078-pxggjaby	170	4	,	,	,
cord-297078-pxggjaby	170	5	bacterial	bacterial	JJ
cord-297078-pxggjaby	170	6	,	,	,
cord-297078-pxggjaby	170	7	and	and	CC
cord-297078-pxggjaby	170	8	eukaryotic	eukaryotic	NNP
cord-297078-pxggjaby	170	9	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	170	10	RNA	RNA	NNP
cord-297078-pxggjaby	170	11	polymerases	polymerase	NNS
cord-297078-pxggjaby	170	12	all	all	DT
cord-297078-pxggjaby	170	13	share	share	VBP
cord-297078-pxggjaby	170	14	a	a	DT
cord-297078-pxggjaby	170	15	common	common	JJ
cord-297078-pxggjaby	170	16	core	core	NN
cord-297078-pxggjaby	170	17	of	of	IN
cord-297078-pxggjaby	170	18	four	four	CD
cord-297078-pxggjaby	170	19	subunits	subunit	NNS
cord-297078-pxggjaby	170	20	(	(	-LRB-
cord-297078-pxggjaby	170	21	corresponding	correspond	VBG
cord-297078-pxggjaby	170	22	to	to	IN
cord-297078-pxggjaby	170	23	bacterial	bacterial	JJ
cord-297078-pxggjaby	170	24	subunits	subunit	NNS
cord-297078-pxggjaby	170	25	a	a	DT
cord-297078-pxggjaby	170	26	,	,	,
cord-297078-pxggjaby	170	27	b	b	NN
cord-297078-pxggjaby	170	28	,	,	,
cord-297078-pxggjaby	170	29	b	b	NN
cord-297078-pxggjaby	170	30	#	#	NN
cord-297078-pxggjaby	170	31	,	,	,
cord-297078-pxggjaby	171	1	and	and	CC
cord-297078-pxggjaby	171	2	x	x	LS
cord-297078-pxggjaby	171	3	[	[	-LRB-
cord-297078-pxggjaby	171	4	the	the	DT
cord-297078-pxggjaby	171	5	a	a	DT
cord-297078-pxggjaby	171	6	subunit	subunit	NN
cord-297078-pxggjaby	171	7	is	be	VBZ
cord-297078-pxggjaby	171	8	present	present	JJ
cord-297078-pxggjaby	171	9	in	in	IN
cord-297078-pxggjaby	171	10	two	two	CD
cord-297078-pxggjaby	171	11	copies	copy	NNS
cord-297078-pxggjaby	171	12	in	in	IN
cord-297078-pxggjaby	171	13	bacterial	bacterial	JJ
cord-297078-pxggjaby	171	14	RNA	RNA	NNP
cord-297078-pxggjaby	171	15	polymerase	polymerase	NN
cord-297078-pxggjaby	171	16	;	;	:
cord-297078-pxggjaby	171	17	in	in	IN
cord-297078-pxggjaby	171	18	Archaea	Archaea	NNP
cord-297078-pxggjaby	171	19	there	there	EX
cord-297078-pxggjaby	171	20	are	be	VBP
cord-297078-pxggjaby	171	21	two	two	CD
cord-297078-pxggjaby	171	22	separate	separate	JJ
cord-297078-pxggjaby	171	23	subunits	subunit	NNS
cord-297078-pxggjaby	171	24	with	with	IN
cord-297078-pxggjaby	171	25	homology	homology	NN
cord-297078-pxggjaby	171	26	to	to	IN
cord-297078-pxggjaby	171	27	a	a	DT
cord-297078-pxggjaby	171	28	(	(	-LRB-
cord-297078-pxggjaby	171	29	subunits	subunit	NNS
cord-297078-pxggjaby	171	30	D	D	NNP
cord-297078-pxggjaby	171	31	and	and	CC
cord-297078-pxggjaby	171	32	L	L	NNP
cord-297078-pxggjaby	171	33	)	)	-RRB-
cord-297078-pxggjaby	171	34	,	,	,
cord-297078-pxggjaby	171	35	and	and	CC
cord-297078-pxggjaby	171	36	the	the	DT
cord-297078-pxggjaby	171	37	same	same	JJ
cord-297078-pxggjaby	171	38	is	be	VBZ
cord-297078-pxggjaby	171	39	true	true	JJ
cord-297078-pxggjaby	171	40	for	for	IN
cord-297078-pxggjaby	171	41	Eukaryotes	eukaryote	NNS
cord-297078-pxggjaby	171	42	(	(	-LRB-
cord-297078-pxggjaby	171	43	Rbp3	Rbp3	NNP
cord-297078-pxggjaby	171	44	and	and	CC
cord-297078-pxggjaby	171	45	Rbp11	Rbp11	NNP
cord-297078-pxggjaby	171	46	)	)	-RRB-
cord-297078-pxggjaby	171	47	(	(	-LRB-
cord-297078-pxggjaby	171	48	Cramer	Cramer	NNP
cord-297078-pxggjaby	171	49	2002a	2002a	CD
cord-297078-pxggjaby	171	50	)	)	-RRB-
cord-297078-pxggjaby	171	51	]	]	-RRB-
cord-297078-pxggjaby	171	52	)	)	-RRB-
cord-297078-pxggjaby	171	53	,	,	,
cord-297078-pxggjaby	171	54	as	as	IN
cord-297078-pxggjaby	171	55	evidenced	evidence	VBN
cord-297078-pxggjaby	171	56	from	from	IN
cord-297078-pxggjaby	171	57	inspection	inspection	NN
cord-297078-pxggjaby	171	58	of	of	IN
cord-297078-pxggjaby	171	59	the	the	DT
cord-297078-pxggjaby	171	60	available	available	JJ
cord-297078-pxggjaby	171	61	structures	structure	NNS
cord-297078-pxggjaby	171	62	from	from	IN
cord-297078-pxggjaby	171	63	bacteria	bacteria	NNS
cord-297078-pxggjaby	171	64	and	and	CC
cord-297078-pxggjaby	171	65	eukaryotes	eukaryote	NNS
cord-297078-pxggjaby	171	66	,	,	,
cord-297078-pxggjaby	171	67	together	together	RB
cord-297078-pxggjaby	171	68	with	with	IN
cord-297078-pxggjaby	171	69	sequence	sequence	NN
cord-297078-pxggjaby	171	70	similarities	similarity	NNS
cord-297078-pxggjaby	171	71	(	(	-LRB-
cord-297078-pxggjaby	171	72	Cramer	Cramer	NNP
cord-297078-pxggjaby	171	73	2002a	2002a	CD
cord-297078-pxggjaby	171	74	)	)	-RRB-
cord-297078-pxggjaby	171	75	.	.	.
cord-297078-pxggjaby	172	1	Consistent	consistent	JJ
cord-297078-pxggjaby	172	2	with	with	IN
cord-297078-pxggjaby	172	3	placement	placement	NN
cord-297078-pxggjaby	172	4	in	in	IN
cord-297078-pxggjaby	172	5	LUCA	LUCA	NNP
cord-297078-pxggjaby	172	6	,	,	,
cord-297078-pxggjaby	172	7	the	the	DT
cord-297078-pxggjaby	172	8	two	two	CD
cord-297078-pxggjaby	172	9	largest	large	JJS
cord-297078-pxggjaby	172	10	subunits	subunit	NNS
cord-297078-pxggjaby	172	11	of	of	IN
cord-297078-pxggjaby	172	12	RNA	RNA	NNP
cord-297078-pxggjaby	172	13	polymerase	polymerase	NN
cord-297078-pxggjaby	172	14	(	(	-LRB-
cord-297078-pxggjaby	172	15	b	b	NN
cord-297078-pxggjaby	172	16	and	and	CC
cord-297078-pxggjaby	172	17	b	b	LS
cord-297078-pxggjaby	172	18	#	#	$
cord-297078-pxggjaby	172	19	)	)	-RRB-
cord-297078-pxggjaby	172	20	are	be	VBP
cord-297078-pxggjaby	172	21	routinely	routinely	RB
cord-297078-pxggjaby	172	22	used	use	VBN
cord-297078-pxggjaby	172	23	as	as	IN
cord-297078-pxggjaby	172	24	markers	marker	NNS
cord-297078-pxggjaby	172	25	in	in	IN
cord-297078-pxggjaby	172	26	phylogenetic	phylogenetic	JJ
cord-297078-pxggjaby	172	27	reconstructions	reconstruction	NNS
cord-297078-pxggjaby	172	28	.	.	.
cord-297078-pxggjaby	173	1	There	there	EX
cord-297078-pxggjaby	173	2	is	be	VBZ
cord-297078-pxggjaby	173	3	no	no	DT
cord-297078-pxggjaby	173	4	evidence	evidence	NN
cord-297078-pxggjaby	173	5	for	for	IN
cord-297078-pxggjaby	173	6	extensive	extensive	JJ
cord-297078-pxggjaby	173	7	,	,	,
cord-297078-pxggjaby	173	8	domain	domain	NN
cord-297078-pxggjaby	173	9	-	-	HYPH
cord-297078-pxggjaby	173	10	level	level	NN
cord-297078-pxggjaby	173	11	horizontal	horizontal	JJ
cord-297078-pxggjaby	173	12	transfer	transfer	NN
cord-297078-pxggjaby	173	13	,	,	,
cord-297078-pxggjaby	173	14	and	and	CC
cord-297078-pxggjaby	173	15	the	the	DT
cord-297078-pxggjaby	173	16	resulting	result	VBG
cord-297078-pxggjaby	173	17	trees	tree	NNS
cord-297078-pxggjaby	173	18	are	be	VBP
cord-297078-pxggjaby	173	19	congruent	congruent	JJ
cord-297078-pxggjaby	173	20	with	with	IN
cord-297078-pxggjaby	173	21	trees	tree	NNS
cord-297078-pxggjaby	173	22	constructed	construct	VBN
cord-297078-pxggjaby	173	23	using	use	VBG
cord-297078-pxggjaby	173	24	rRNA	rRNA	NNP
cord-297078-pxggjaby	173	25	(	(	-LRB-
cord-297078-pxggjaby	173	26	Tourasse	Tourasse	NNP
cord-297078-pxggjaby	173	27	and	and	CC
cord-297078-pxggjaby	173	28	Gouy	Gouy	NNP
cord-297078-pxggjaby	173	29	1999	1999	CD
cord-297078-pxggjaby	173	30	)	)	-RRB-
cord-297078-pxggjaby	174	1	(	(	-LRB-
cord-297078-pxggjaby	174	2	while	while	IN
cord-297078-pxggjaby	174	3	establishing	establish	VBG
cord-297078-pxggjaby	174	4	the	the	DT
cord-297078-pxggjaby	174	5	correct	correct	JJ
cord-297078-pxggjaby	174	6	topology	topology	NN
cord-297078-pxggjaby	174	7	is	be	VBZ
cord-297078-pxggjaby	174	8	nontrivial	nontrivial	JJ
cord-297078-pxggjaby	174	9	,	,	,
cord-297078-pxggjaby	174	10	see	see	VB
cord-297078-pxggjaby	174	11	Tourasse	Tourasse	NNP
cord-297078-pxggjaby	174	12	and	and	CC
cord-297078-pxggjaby	174	13	Gouy	Gouy	NNP
cord-297078-pxggjaby	174	14	[	[	-LRB-
cord-297078-pxggjaby	174	15	1999	1999	CD
cord-297078-pxggjaby	174	16	]	]	-RRB-
cord-297078-pxggjaby	174	17	,	,	,
cord-297078-pxggjaby	174	18	topology	topology	NN
cord-297078-pxggjaby	174	19	does	do	VBZ
cord-297078-pxggjaby	174	20	not	not	RB
cord-297078-pxggjaby	174	21	affect	affect	VB
cord-297078-pxggjaby	174	22	the	the	DT
cord-297078-pxggjaby	174	23	conclusion	conclusion	NN
cord-297078-pxggjaby	174	24	that	that	IN
cord-297078-pxggjaby	174	25	these	these	DT
cord-297078-pxggjaby	174	26	two	two	CD
cord-297078-pxggjaby	174	27	subunits	subunit	NNS
cord-297078-pxggjaby	174	28	can	can	MD
cord-297078-pxggjaby	174	29	be	be	VB
cord-297078-pxggjaby	174	30	traced	trace	VBN
cord-297078-pxggjaby	174	31	back	back	RB
cord-297078-pxggjaby	174	32	to	to	IN
cord-297078-pxggjaby	174	33	the	the	DT
cord-297078-pxggjaby	174	34	LUCA	LUCA	NNP
cord-297078-pxggjaby	174	35	)	)	-RRB-
cord-297078-pxggjaby	174	36	.	.	.
cord-297078-pxggjaby	175	1	Furthermore	furthermore	RB
cord-297078-pxggjaby	175	2	,	,	,
cord-297078-pxggjaby	175	3	Harris	Harris	NNP
cord-297078-pxggjaby	175	4	et	et	NNP
cord-297078-pxggjaby	175	5	al	al	NNP
cord-297078-pxggjaby	175	6	.	.	.
cord-297078-pxggjaby	176	1	(	(	-LRB-
cord-297078-pxggjaby	176	2	2003	2003	CD
cord-297078-pxggjaby	176	3	)	)	-RRB-
cord-297078-pxggjaby	176	4	report	report	VBP
cord-297078-pxggjaby	176	5	that	that	IN
cord-297078-pxggjaby	176	6	the	the	DT
cord-297078-pxggjaby	176	7	a	a	DT
cord-297078-pxggjaby	176	8	subunit	subunit	NN
cord-297078-pxggjaby	176	9	also	also	RB
cord-297078-pxggjaby	176	10	produces	produce	VBZ
cord-297078-pxggjaby	176	11	a	a	DT
cord-297078-pxggjaby	176	12	tree	tree	NN
cord-297078-pxggjaby	176	13	congruent	congruent	JJ
cord-297078-pxggjaby	176	14	with	with	IN
cord-297078-pxggjaby	176	15	rRNA	rrna	NN
cord-297078-pxggjaby	176	16	and	and	CC
cord-297078-pxggjaby	176	17	can	can	MD
cord-297078-pxggjaby	176	18	thus	thus	RB
cord-297078-pxggjaby	176	19	be	be	VB
cord-297078-pxggjaby	176	20	placed	place	VBN
cord-297078-pxggjaby	176	21	in	in	IN
cord-297078-pxggjaby	176	22	the	the	DT
cord-297078-pxggjaby	176	23	LUCA	LUCA	NNP
cord-297078-pxggjaby	176	24	on	on	IN
cord-297078-pxggjaby	176	25	phylogenetic	phylogenetic	JJ
cord-297078-pxggjaby	176	26	grounds	ground	NNS
cord-297078-pxggjaby	176	27	,	,	,
cord-297078-pxggjaby	176	28	consistent	consistent	JJ
cord-297078-pxggjaby	176	29	with	with	IN
cord-297078-pxggjaby	176	30	results	result	NNS
cord-297078-pxggjaby	176	31	from	from	IN
cord-297078-pxggjaby	176	32	other	other	JJ
cord-297078-pxggjaby	176	33	authors	author	NNS
cord-297078-pxggjaby	176	34	(	(	-LRB-
cord-297078-pxggjaby	176	35	Koonin	Koonin	NNP
cord-297078-pxggjaby	176	36	2003	2003	CD
cord-297078-pxggjaby	176	37	)	)	-RRB-
cord-297078-pxggjaby	176	38	.	.	.
cord-297078-pxggjaby	177	1	The	the	DT
cord-297078-pxggjaby	177	2	second	second	JJ
cord-297078-pxggjaby	177	3	point	point	NN
cord-297078-pxggjaby	177	4	regarding	regard	VBG
cord-297078-pxggjaby	177	5	the	the	DT
cord-297078-pxggjaby	177	6	antiquity	antiquity	NN
cord-297078-pxggjaby	177	7	of	of	IN
cord-297078-pxggjaby	177	8	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	177	9	RNA	RNA	NNP
cord-297078-pxggjaby	177	10	polymerase	polymerase	NN
cord-297078-pxggjaby	177	11	relates	relate	VBZ
cord-297078-pxggjaby	177	12	to	to	IN
cord-297078-pxggjaby	177	13	catalysis	catalysis	NN
cord-297078-pxggjaby	177	14	.	.	.
cord-297078-pxggjaby	178	1	Both	both	DT
cord-297078-pxggjaby	178	2	the	the	DT
cord-297078-pxggjaby	178	3	polymerase	polymerase	NN
cord-297078-pxggjaby	178	4	and	and	CC
cord-297078-pxggjaby	178	5	repair	repair	NN
cord-297078-pxggjaby	178	6	activities	activity	NNS
cord-297078-pxggjaby	178	7	have	have	VBP
cord-297078-pxggjaby	178	8	been	be	VBN
cord-297078-pxggjaby	178	9	incontrovertibly	incontrovertibly	RB
cord-297078-pxggjaby	178	10	demonstrated	demonstrate	VBN
cord-297078-pxggjaby	178	11	to	to	TO
cord-297078-pxggjaby	178	12	lie	lie	VB
cord-297078-pxggjaby	178	13	within	within	IN
cord-297078-pxggjaby	178	14	the	the	DT
cord-297078-pxggjaby	178	15	conserved	conserved	JJ
cord-297078-pxggjaby	178	16	catalytic	catalytic	JJ
cord-297078-pxggjaby	178	17	core	core	NN
cord-297078-pxggjaby	178	18	;	;	,
cord-297078-pxggjaby	178	19	coordination	coordination	NN
cord-297078-pxggjaby	178	20	of	of	IN
cord-297078-pxggjaby	178	21	the	the	DT
cord-297078-pxggjaby	178	22	two	two	CD
cord-297078-pxggjaby	178	23	metal	metal	NN
cord-297078-pxggjaby	178	24	ions	ion	NNS
cord-297078-pxggjaby	178	25	required	require	VBN
cord-297078-pxggjaby	178	26	for	for	IN
cord-297078-pxggjaby	178	27	catalysis	catalysis	NN
cord-297078-pxggjaby	178	28	is	be	VBZ
cord-297078-pxggjaby	178	29	shared	share	VBN
cord-297078-pxggjaby	178	30	between	between	IN
cord-297078-pxggjaby	178	31	the	the	DT
cord-297078-pxggjaby	178	32	b	b	NN
cord-297078-pxggjaby	178	33	#	#	NN
cord-297078-pxggjaby	178	34	and	and	CC
cord-297078-pxggjaby	178	35	b	b	NN
cord-297078-pxggjaby	178	36	subunits	subunit	NNS
cord-297078-pxggjaby	178	37	(	(	-LRB-
cord-297078-pxggjaby	178	38	fig	fig	NN
cord-297078-pxggjaby	178	39	.	.	.
cord-297078-pxggjaby	179	1	3c	3c	NNP
cord-297078-pxggjaby	179	2	and	and	CC
cord-297078-pxggjaby	179	3	d	d	NNP
cord-297078-pxggjaby	179	4	)	)	-RRB-
cord-297078-pxggjaby	179	5	.	.	.
cord-297078-pxggjaby	180	1	Significantly	significantly	RB
cord-297078-pxggjaby	180	2	,	,	,
cord-297078-pxggjaby	180	3	a	a	DT
cord-297078-pxggjaby	180	4	careful	careful	JJ
cord-297078-pxggjaby	180	5	sequence	sequence	NN
cord-297078-pxggjaby	180	6	-	-	HYPH
cord-297078-pxggjaby	180	7	based	base	VBN
cord-297078-pxggjaby	180	8	comparison	comparison	NN
cord-297078-pxggjaby	180	9	has	have	VBZ
cord-297078-pxggjaby	180	10	led	lead	VBN
cord-297078-pxggjaby	180	11	to	to	IN
cord-297078-pxggjaby	180	12	speculation	speculation	NN
cord-297078-pxggjaby	180	13	that	that	IN
cord-297078-pxggjaby	180	14	modern	modern	JJ
cord-297078-pxggjaby	180	15	RNA	RNA	NNP
cord-297078-pxggjaby	180	16	polymerases	polymerase	NNS
cord-297078-pxggjaby	180	17	evolved	evolve	VBN
cord-297078-pxggjaby	180	18	from	from	IN
cord-297078-pxggjaby	180	19	a	a	DT
cord-297078-pxggjaby	180	20	homodimeric	homodimeric	NNP
cord-297078-pxggjaby	180	21	RNAbinding	rnabinding	NN
cord-297078-pxggjaby	180	22	domain	domain	NN
cord-297078-pxggjaby	180	23	(	(	-LRB-
cord-297078-pxggjaby	180	24	perhaps	perhaps	RB
cord-297078-pxggjaby	180	25	acting	act	VBG
cord-297078-pxggjaby	180	26	in	in	IN
cord-297078-pxggjaby	180	27	some	some	DT
cord-297078-pxggjaby	180	28	ancillary	ancillary	JJ
cord-297078-pxggjaby	180	29	capacity	capacity	NN
cord-297078-pxggjaby	180	30	together	together	RB
cord-297078-pxggjaby	180	31	with	with	IN
cord-297078-pxggjaby	180	32	a	a	DT
cord-297078-pxggjaby	180	33	ribozyme	ribozyme	NN
cord-297078-pxggjaby	180	34	RNA	rna	NN
cord-297078-pxggjaby	180	35	polymerase	polymerase	NN
cord-297078-pxggjaby	180	36	;	;	:
cord-297078-pxggjaby	180	37	Iyer	Iyer	NNP
cord-297078-pxggjaby	180	38	,	,	,
cord-297078-pxggjaby	180	39	Koonin	Koonin	NNP
cord-297078-pxggjaby	180	40	,	,	,
cord-297078-pxggjaby	180	41	and	and	CC
cord-297078-pxggjaby	180	42	Aravind	Aravind	NNP
cord-297078-pxggjaby	180	43	[	[	-LRB-
cord-297078-pxggjaby	180	44	2003	2003	CD
cord-297078-pxggjaby	180	45	]	]	-RRB-
cord-297078-pxggjaby	180	46	)	)	-RRB-
cord-297078-pxggjaby	180	47	.	.	.
cord-297078-pxggjaby	181	1	However	however	RB
cord-297078-pxggjaby	181	2	,	,	,
cord-297078-pxggjaby	181	3	this	this	DT
cord-297078-pxggjaby	181	4	ultimate	ultimate	JJ
cord-297078-pxggjaby	181	5	origin	origin	NN
cord-297078-pxggjaby	181	6	should	should	MD
cord-297078-pxggjaby	181	7	be	be	VB
cord-297078-pxggjaby	181	8	taken	take	VBN
cord-297078-pxggjaby	181	9	to	to	TO
cord-297078-pxggjaby	181	10	represent	represent	VB
cord-297078-pxggjaby	181	11	a	a	DT
cord-297078-pxggjaby	181	12	probable	probable	JJ
cord-297078-pxggjaby	181	13	earlier	early	JJR
cord-297078-pxggjaby	181	14	intermediate	intermediate	JJ
cord-297078-pxggjaby	181	15	stage	stage	NN
cord-297078-pxggjaby	181	16	;	;	:
cord-297078-pxggjaby	181	17	on	on	IN
cord-297078-pxggjaby	181	18	evidence	evidence	NN
cord-297078-pxggjaby	181	19	,	,	,
cord-297078-pxggjaby	181	20	LUCA	LUCA	NNP
cord-297078-pxggjaby	181	21	would	would	MD
cord-297078-pxggjaby	181	22	have	have	VB
cord-297078-pxggjaby	181	23	possessed	possess	VBN
cord-297078-pxggjaby	181	24	an	an	DT
cord-297078-pxggjaby	181	25	RNA	RNA	NNP
cord-297078-pxggjaby	181	26	polymerase	polymerase	NN
cord-297078-pxggjaby	181	27	resembling	resemble	VBG
cord-297078-pxggjaby	181	28	a	a	DT
cord-297078-pxggjaby	181	29	modern	modern	JJ
cord-297078-pxggjaby	181	30	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	181	31	RNA	rna	NN
cord-297078-pxggjaby	181	32	polymerase	polymerase	NN
cord-297078-pxggjaby	181	33	.	.	.
cord-297078-pxggjaby	182	1	That	that	IN
cord-297078-pxggjaby	182	2	the	the	DT
cord-297078-pxggjaby	182	3	capacity	capacity	NN
cord-297078-pxggjaby	182	4	for	for	IN
cord-297078-pxggjaby	182	5	repair	repair	NN
cord-297078-pxggjaby	182	6	appears	appear	VBZ
cord-297078-pxggjaby	182	7	to	to	TO
cord-297078-pxggjaby	182	8	be	be	VB
cord-297078-pxggjaby	182	9	a	a	DT
cord-297078-pxggjaby	182	10	consequence	consequence	NN
cord-297078-pxggjaby	182	11	of	of	IN
cord-297078-pxggjaby	182	12	the	the	DT
cord-297078-pxggjaby	182	13	common	common	JJ
cord-297078-pxggjaby	182	14	two	two	CD
cord-297078-pxggjaby	182	15	-	-	HYPH
cord-297078-pxggjaby	182	16	metal	metal	NN
cord-297078-pxggjaby	182	17	mechanism	mechanism	NN
cord-297078-pxggjaby	182	18	for	for	IN
cord-297078-pxggjaby	182	19	elongation	elongation	NN
cord-297078-pxggjaby	182	20	implies	imply	VBZ
cord-297078-pxggjaby	182	21	that	that	IN
cord-297078-pxggjaby	182	22	,	,	,
cord-297078-pxggjaby	182	23	at	at	IN
cord-297078-pxggjaby	182	24	the	the	DT
cord-297078-pxggjaby	182	25	very	very	RB
cord-297078-pxggjaby	182	26	least	least	JJS
cord-297078-pxggjaby	182	27	,	,	,
cord-297078-pxggjaby	182	28	the	the	DT
cord-297078-pxggjaby	182	29	RNA	RNA	NNP
cord-297078-pxggjaby	182	30	polymerase	polymerase	NN
cord-297078-pxggjaby	182	31	in	in	IN
cord-297078-pxggjaby	182	32	LUCA	LUCA	NNP
cord-297078-pxggjaby	182	33	possessed	possess	VBD
cord-297078-pxggjaby	182	34	the	the	DT
cord-297078-pxggjaby	182	35	capacity	capacity	NN
cord-297078-pxggjaby	182	36	for	for	IN
cord-297078-pxggjaby	182	37	repair	repair	NN
cord-297078-pxggjaby	182	38	.	.	.
cord-297078-pxggjaby	183	1	Whether	whether	IN
cord-297078-pxggjaby	183	2	genomic	genomic	JJ
cord-297078-pxggjaby	183	3	RNA	RNA	NNP
cord-297078-pxggjaby	183	4	repair	repair	NN
cord-297078-pxggjaby	183	5	was	be	VBD
cord-297078-pxggjaby	183	6	a	a	DT
cord-297078-pxggjaby	183	7	feature	feature	NN
cord-297078-pxggjaby	183	8	of	of	IN
cord-297078-pxggjaby	183	9	the	the	DT
cord-297078-pxggjaby	183	10	LUCA	LUCA	NNP
cord-297078-pxggjaby	183	11	is	be	VBZ
cord-297078-pxggjaby	183	12	somewhat	somewhat	RB
cord-297078-pxggjaby	183	13	harder	hard	JJR
cord-297078-pxggjaby	183	14	to	to	TO
cord-297078-pxggjaby	183	15	judge	judge	VB
cord-297078-pxggjaby	183	16	and	and	CC
cord-297078-pxggjaby	183	17	will	will	MD
cord-297078-pxggjaby	183	18	be	be	VB
cord-297078-pxggjaby	183	19	considered	consider	VBN
cord-297078-pxggjaby	183	20	next	next	JJ
cord-297078-pxggjaby	183	21	.	.	.
cord-297078-pxggjaby	184	1	Owing	owe	VBG
cord-297078-pxggjaby	184	2	to	to	IN
cord-297078-pxggjaby	184	3	the	the	DT
cord-297078-pxggjaby	184	4	nature	nature	NN
cord-297078-pxggjaby	184	5	of	of	IN
cord-297078-pxggjaby	184	6	the	the	DT
cord-297078-pxggjaby	184	7	catalytic	catalytic	JJ
cord-297078-pxggjaby	184	8	site	site	NN
cord-297078-pxggjaby	184	9	,	,	,
cord-297078-pxggjaby	184	10	RNA	RNA	NNP
cord-297078-pxggjaby	184	11	repair	repair	NN
cord-297078-pxggjaby	184	12	could	could	MD
cord-297078-pxggjaby	184	13	most	most	RBS
cord-297078-pxggjaby	184	14	definitely	definitely	RB
cord-297078-pxggjaby	184	15	have	have	VB
cord-297078-pxggjaby	184	16	been	be	VBN
cord-297078-pxggjaby	184	17	a	a	DT
cord-297078-pxggjaby	184	18	feature	feature	NN
cord-297078-pxggjaby	184	19	of	of	IN
cord-297078-pxggjaby	184	20	the	the	DT
cord-297078-pxggjaby	184	21	LUCA	LUCA	NNP
cord-297078-pxggjaby	184	22	.	.	.
cord-297078-pxggjaby	185	1	However	however	RB
cord-297078-pxggjaby	185	2	,	,	,
cord-297078-pxggjaby	185	3	in	in	IN
cord-297078-pxggjaby	185	4	answering	answer	VBG
cord-297078-pxggjaby	185	5	the	the	DT
cord-297078-pxggjaby	185	6	question	question	NN
cord-297078-pxggjaby	185	7	above	above	RB
cord-297078-pxggjaby	185	8	,	,	,
cord-297078-pxggjaby	185	9	several	several	JJ
cord-297078-pxggjaby	185	10	points	point	NNS
cord-297078-pxggjaby	185	11	should	should	MD
cord-297078-pxggjaby	185	12	be	be	VB
cord-297078-pxggjaby	185	13	borne	bear	VBN
cord-297078-pxggjaby	185	14	in	in	IN
cord-297078-pxggjaby	185	15	mind	mind	NN
cord-297078-pxggjaby	185	16	.	.	.
cord-297078-pxggjaby	186	1	Firstly	firstly	RB
cord-297078-pxggjaby	186	2	,	,	,
cord-297078-pxggjaby	186	3	the	the	DT
cord-297078-pxggjaby	186	4	argument	argument	NN
cord-297078-pxggjaby	186	5	for	for	IN
cord-297078-pxggjaby	186	6	genomic	genomic	JJ
cord-297078-pxggjaby	186	7	RNA	RNA	NNP
cord-297078-pxggjaby	186	8	repair	repair	NN
cord-297078-pxggjaby	186	9	in	in	IN
cord-297078-pxggjaby	186	10	LUCA	LUCA	NNP
cord-297078-pxggjaby	186	11	is	be	VBZ
cord-297078-pxggjaby	186	12	complicated	complicate	VBN
cord-297078-pxggjaby	186	13	,	,	,
cord-297078-pxggjaby	186	14	and	and	CC
cord-297078-pxggjaby	186	15	perhaps	perhaps	RB
cord-297078-pxggjaby	186	16	weakened	weaken	VBN
cord-297078-pxggjaby	186	17	,	,	,
cord-297078-pxggjaby	186	18	by	by	IN
cord-297078-pxggjaby	186	19	the	the	DT
cord-297078-pxggjaby	186	20	difficulty	difficulty	NN
cord-297078-pxggjaby	186	21	in	in	IN
cord-297078-pxggjaby	186	22	establishing	establish	VBG
cord-297078-pxggjaby	186	23	whether	whether	IN
cord-297078-pxggjaby	186	24	or	or	CC
cord-297078-pxggjaby	186	25	not	not	RB
cord-297078-pxggjaby	186	26	DNA	DNA	NNP
cord-297078-pxggjaby	186	27	was	be	VBD
cord-297078-pxggjaby	186	28	present	present	JJ
cord-297078-pxggjaby	186	29	.	.	.
cord-297078-pxggjaby	187	1	Secondly	secondly	RB
cord-297078-pxggjaby	187	2	,	,	,
cord-297078-pxggjaby	187	3	this	this	DT
cord-297078-pxggjaby	187	4	thesis	thesis	NN
cord-297078-pxggjaby	187	5	extrapolates	extrapolate	VBZ
cord-297078-pxggjaby	187	6	a	a	DT
cord-297078-pxggjaby	187	7	modern	modern	JJ
cord-297078-pxggjaby	187	8	function	function	NN
cord-297078-pxggjaby	187	9	in	in	IN
cord-297078-pxggjaby	187	10	mRNA	mRNA	NNP
cord-297078-pxggjaby	187	11	quality	quality	NN
cord-297078-pxggjaby	187	12	control	control	NN
cord-297078-pxggjaby	187	13	by	by	IN
cord-297078-pxggjaby	187	14	polymerases	polymerase	NNS
cord-297078-pxggjaby	187	15	reading	read	VBG
cord-297078-pxggjaby	187	16	off	off	RP
cord-297078-pxggjaby	187	17	DNA	dna	NN
cord-297078-pxggjaby	187	18	templates	template	NNS
cord-297078-pxggjaby	187	19	to	to	IN
cord-297078-pxggjaby	187	20	an	an	DT
cord-297078-pxggjaby	187	21	ancestral	ancestral	JJ
cord-297078-pxggjaby	187	22	function	function	NN
cord-297078-pxggjaby	187	23	in	in	IN
cord-297078-pxggjaby	187	24	genome	genome	NN
cord-297078-pxggjaby	187	25	replication	replication	NN
cord-297078-pxggjaby	187	26	by	by	IN
cord-297078-pxggjaby	187	27	polymerases	polymerase	NNS
cord-297078-pxggjaby	187	28	reading	read	VBG
cord-297078-pxggjaby	187	29	off	off	RP
cord-297078-pxggjaby	187	30	RNA	RNA	NNP
cord-297078-pxggjaby	187	31	templates	template	NNS
cord-297078-pxggjaby	187	32	.	.	.
cord-297078-pxggjaby	188	1	The	the	DT
cord-297078-pxggjaby	188	2	third	third	JJ
cord-297078-pxggjaby	188	3	is	be	VBZ
cord-297078-pxggjaby	188	4	somewhat	somewhat	RB
cord-297078-pxggjaby	188	5	dependent	dependent	JJ
cord-297078-pxggjaby	188	6	on	on	IN
cord-297078-pxggjaby	188	7	the	the	DT
cord-297078-pxggjaby	188	8	first	first	JJ
cord-297078-pxggjaby	188	9	;	;	:
cord-297078-pxggjaby	188	10	assuming	assume	VBG
cord-297078-pxggjaby	188	11	RNA	RNA	NNP
cord-297078-pxggjaby	188	12	repair	repair	NN
cord-297078-pxggjaby	188	13	was	be	VBD
cord-297078-pxggjaby	188	14	present	present	JJ
cord-297078-pxggjaby	188	15	,	,	,
cord-297078-pxggjaby	188	16	was	be	VBD
cord-297078-pxggjaby	188	17	it	-PRON-	PRP
cord-297078-pxggjaby	188	18	involved	involved	JJ
cord-297078-pxggjaby	188	19	in	in	IN
cord-297078-pxggjaby	188	20	quality	quality	NN
cord-297078-pxggjaby	188	21	control	control	NN
cord-297078-pxggjaby	188	22	,	,	,
cord-297078-pxggjaby	188	23	genome	genome	NN
cord-297078-pxggjaby	188	24	replication	replication	NN
cord-297078-pxggjaby	188	25	,	,	,
cord-297078-pxggjaby	188	26	or	or	CC
cord-297078-pxggjaby	188	27	both	both	DT
cord-297078-pxggjaby	188	28	?	?	.
cord-297078-pxggjaby	189	1	Given	give	VBN
cord-297078-pxggjaby	189	2	that	that	IN
cord-297078-pxggjaby	189	3	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	189	4	reductases	reductase	NNS
cord-297078-pxggjaby	189	5	can	can	MD
cord-297078-pxggjaby	189	6	not	not	RB
cord-297078-pxggjaby	189	7	be	be	VB
cord-297078-pxggjaby	189	8	unambiguously	unambiguously	RB
cord-297078-pxggjaby	189	9	placed	place	VBN
cord-297078-pxggjaby	189	10	in	in	IN
cord-297078-pxggjaby	189	11	LUCA	LUCA	NNP
cord-297078-pxggjaby	189	12	,	,	,
cord-297078-pxggjaby	189	13	despite	despite	IN
cord-297078-pxggjaby	189	14	being	be	VBG
cord-297078-pxggjaby	189	15	ubiquitous	ubiquitous	JJ
cord-297078-pxggjaby	189	16	,	,	,
cord-297078-pxggjaby	189	17	and	and	CC
cord-297078-pxggjaby	189	18	given	give	VBN
cord-297078-pxggjaby	189	19	that	that	IN
cord-297078-pxggjaby	189	20	the	the	DT
cord-297078-pxggjaby	189	21	DNA	dna	NN
cord-297078-pxggjaby	189	22	replication	replication	NN
cord-297078-pxggjaby	189	23	apparatus	apparatus	NN
cord-297078-pxggjaby	189	24	has	have	VBZ
cord-297078-pxggjaby	189	25	evolved	evolve	VBN
cord-297078-pxggjaby	189	26	twice	twice	RB
cord-297078-pxggjaby	189	27	,	,	,
cord-297078-pxggjaby	189	28	it	-PRON-	PRP
cord-297078-pxggjaby	189	29	is	be	VBZ
cord-297078-pxggjaby	189	30	currently	currently	RB
cord-297078-pxggjaby	189	31	unclear	unclear	JJ
cord-297078-pxggjaby	189	32	if	if	IN
cord-297078-pxggjaby	189	33	DNA	DNA	NNP
cord-297078-pxggjaby	189	34	was	be	VBD
cord-297078-pxggjaby	189	35	a	a	DT
cord-297078-pxggjaby	189	36	feature	feature	NN
cord-297078-pxggjaby	189	37	of	of	IN
cord-297078-pxggjaby	189	38	LUCA	LUCA	NNP
cord-297078-pxggjaby	189	39	,	,	,
cord-297078-pxggjaby	189	40	with	with	IN
cord-297078-pxggjaby	189	41	one	one	CD
cord-297078-pxggjaby	189	42	of	of	IN
cord-297078-pxggjaby	189	43	the	the	DT
cord-297078-pxggjaby	189	44	two	two	CD
cord-297078-pxggjaby	189	45	forms	form	NNS
cord-297078-pxggjaby	189	46	of	of	IN
cord-297078-pxggjaby	189	47	DNA	dna	NN
cord-297078-pxggjaby	189	48	replication	replication	NN
cord-297078-pxggjaby	189	49	having	have	VBG
cord-297078-pxggjaby	189	50	evolved	evolve	VBN
cord-297078-pxggjaby	189	51	,	,	,
cord-297078-pxggjaby	189	52	with	with	IN
cord-297078-pxggjaby	189	53	the	the	DT
cord-297078-pxggjaby	189	54	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	189	55	reductases	reductase	NNS
cord-297078-pxggjaby	189	56	being	be	VBG
cord-297078-pxggjaby	189	57	present	present	JJ
cord-297078-pxggjaby	190	1	(	(	-LRB-
cord-297078-pxggjaby	190	2	Scenario	scenario	NN
cord-297078-pxggjaby	190	3	1	1	CD
cord-297078-pxggjaby	190	4	)	)	-RRB-
cord-297078-pxggjaby	190	5	or	or	CC
cord-297078-pxggjaby	190	6	whether	whether	IN
cord-297078-pxggjaby	190	7	DNA	dna	NN
cord-297078-pxggjaby	190	8	replication	replication	NN
cord-297078-pxggjaby	190	9	evolved	evolve	VBD
cord-297078-pxggjaby	190	10	twice	twice	RB
cord-297078-pxggjaby	190	11	,	,	,
cord-297078-pxggjaby	190	12	post	post	VB
cord-297078-pxggjaby	190	13	-	-	NN
cord-297078-pxggjaby	190	14	LUCA	LUCA	NNP
cord-297078-pxggjaby	190	15	(	(	-LRB-
cord-297078-pxggjaby	190	16	Scenario	scenario	NN
cord-297078-pxggjaby	190	17	2	2	CD
cord-297078-pxggjaby	190	18	)	)	-RRB-
cord-297078-pxggjaby	190	19	.	.	.
cord-297078-pxggjaby	191	1	Scenario	scenario	NN
cord-297078-pxggjaby	191	2	1	1	CD
cord-297078-pxggjaby	191	3	implies	imply	VBZ
cord-297078-pxggjaby	191	4	near	near	RB
cord-297078-pxggjaby	191	5	-	-	HYPH
cord-297078-pxggjaby	191	6	complete	complete	JJ
cord-297078-pxggjaby	191	7	NOGD	NOGD	NNP
cord-297078-pxggjaby	191	8	of	of	IN
cord-297078-pxggjaby	191	9	the	the	DT
cord-297078-pxggjaby	191	10	incumbent	incumbent	JJ
cord-297078-pxggjaby	191	11	DNA	dna	NN
cord-297078-pxggjaby	191	12	replication	replication	NN
cord-297078-pxggjaby	191	13	apparatus	apparatus	NN
cord-297078-pxggjaby	191	14	.	.	.
cord-297078-pxggjaby	192	1	This	this	DT
cord-297078-pxggjaby	192	2	seems	seem	VBZ
cord-297078-pxggjaby	192	3	hard	hard	JJ
cord-297078-pxggjaby	192	4	to	to	TO
cord-297078-pxggjaby	192	5	swallow	swallow	VB
cord-297078-pxggjaby	192	6	,	,	,
cord-297078-pxggjaby	192	7	though	though	IN
cord-297078-pxggjaby	192	8	this	this	DT
cord-297078-pxggjaby	192	9	is	be	VBZ
cord-297078-pxggjaby	192	10	not	not	RB
cord-297078-pxggjaby	192	11	in	in	IN
cord-297078-pxggjaby	192	12	itself	-PRON-	PRP
cord-297078-pxggjaby	192	13	an	an	DT
cord-297078-pxggjaby	192	14	argument	argument	NN
cord-297078-pxggjaby	192	15	against	against	IN
cord-297078-pxggjaby	192	16	the	the	DT
cord-297078-pxggjaby	192	17	scenario	scenario	NN
cord-297078-pxggjaby	192	18	.	.	.
cord-297078-pxggjaby	193	1	The	the	DT
cord-297078-pxggjaby	193	2	only	only	JJ
cord-297078-pxggjaby	193	3	difference	difference	NN
cord-297078-pxggjaby	193	4	in	in	IN
cord-297078-pxggjaby	193	5	arguing	argue	VBG
cord-297078-pxggjaby	193	6	for	for	IN
cord-297078-pxggjaby	193	7	a	a	DT
cord-297078-pxggjaby	193	8	DNA	dna	NN
cord-297078-pxggjaby	193	9	-	-	HYPH
cord-297078-pxggjaby	193	10	based	base	VBN
cord-297078-pxggjaby	193	11	LUCA	LUCA	NNP
cord-297078-pxggjaby	193	12	scenario	scenario	NN
cord-297078-pxggjaby	193	13	is	be	VBZ
cord-297078-pxggjaby	193	14	that	that	IN
cord-297078-pxggjaby	193	15	it	-PRON-	PRP
cord-297078-pxggjaby	193	16	requires	require	VBZ
cord-297078-pxggjaby	193	17	some	some	DT
cord-297078-pxggjaby	193	18	unknown	unknown	JJ
cord-297078-pxggjaby	193	19	external	external	JJ
cord-297078-pxggjaby	193	20	source	source	NN
cord-297078-pxggjaby	193	21	for	for	IN
cord-297078-pxggjaby	193	22	a	a	DT
cord-297078-pxggjaby	193	23	complex	complex	JJ
cord-297078-pxggjaby	193	24	DNA	dna	NN
cord-297078-pxggjaby	193	25	replication	replication	NN
cord-297078-pxggjaby	193	26	apparatus	apparatus	NN
cord-297078-pxggjaby	193	27	,	,	,
cord-297078-pxggjaby	193	28	and	and	CC
cord-297078-pxggjaby	193	29	Forterre	Forterre	NNP
cord-297078-pxggjaby	193	30	(	(	-LRB-
cord-297078-pxggjaby	193	31	1999	1999	CD
cord-297078-pxggjaby	193	32	Forterre	Forterre	NNP
cord-297078-pxggjaby	193	33	(	(	-LRB-
cord-297078-pxggjaby	193	34	,	,	,
cord-297078-pxggjaby	193	35	2002	2002	CD
cord-297078-pxggjaby	193	36	and	and	CC
cord-297078-pxggjaby	193	37	Villarreal	Villarreal	NNP
cord-297078-pxggjaby	193	38	and	and	CC
cord-297078-pxggjaby	193	39	DeFilippis	DeFilippis	NNP
cord-297078-pxggjaby	193	40	(	(	-LRB-
cord-297078-pxggjaby	193	41	2000	2000	CD
cord-297078-pxggjaby	193	42	)	)	-RRB-
cord-297078-pxggjaby	193	43	have	have	VBP
cord-297078-pxggjaby	193	44	argued	argue	VBN
cord-297078-pxggjaby	193	45	for	for	IN
cord-297078-pxggjaby	193	46	a	a	DT
cord-297078-pxggjaby	193	47	viral	viral	JJ
cord-297078-pxggjaby	193	48	origin	origin	NN
cord-297078-pxggjaby	193	49	for	for	IN
cord-297078-pxggjaby	193	50	at	at	RB
cord-297078-pxggjaby	193	51	least	least	RBS
cord-297078-pxggjaby	193	52	one	one	CD
cord-297078-pxggjaby	193	53	of	of	IN
cord-297078-pxggjaby	193	54	the	the	DT
cord-297078-pxggjaby	193	55	modern	modern	JJ
cord-297078-pxggjaby	193	56	cellular	cellular	JJ
cord-297078-pxggjaby	193	57	forms	form	NNS
cord-297078-pxggjaby	193	58	of	of	IN
cord-297078-pxggjaby	193	59	replication	replication	NN
cord-297078-pxggjaby	193	60	apparatus	apparatus	NN
cord-297078-pxggjaby	193	61	.	.	.
cord-297078-pxggjaby	194	1	However	however	RB
cord-297078-pxggjaby	194	2	,	,	,
cord-297078-pxggjaby	194	3	it	-PRON-	PRP
cord-297078-pxggjaby	194	4	is	be	VBZ
cord-297078-pxggjaby	194	5	worth	worth	JJ
cord-297078-pxggjaby	194	6	noting	note	VBG
cord-297078-pxggjaby	194	7	that	that	IN
cord-297078-pxggjaby	194	8	even	even	RB
cord-297078-pxggjaby	194	9	if	if	IN
cord-297078-pxggjaby	194	10	a	a	DT
cord-297078-pxggjaby	194	11	viral	viral	JJ
cord-297078-pxggjaby	194	12	origin	origin	NN
cord-297078-pxggjaby	194	13	were	be	VBD
cord-297078-pxggjaby	194	14	unequivocally	unequivocally	RB
cord-297078-pxggjaby	194	15	demonstrated	demonstrate	VBN
cord-297078-pxggjaby	194	16	,	,	,
cord-297078-pxggjaby	194	17	it	-PRON-	PRP
cord-297078-pxggjaby	194	18	is	be	VBZ
cord-297078-pxggjaby	194	19	not	not	RB
cord-297078-pxggjaby	194	20	possible	possible	JJ
cord-297078-pxggjaby	194	21	to	to	TO
cord-297078-pxggjaby	194	22	establish	establish	VB
cord-297078-pxggjaby	194	23	the	the	DT
cord-297078-pxggjaby	194	24	timing	timing	NN
cord-297078-pxggjaby	194	25	of	of	IN
cord-297078-pxggjaby	194	26	the	the	DT
cord-297078-pxggjaby	194	27	origin	origin	NN
cord-297078-pxggjaby	194	28	of	of	IN
cord-297078-pxggjaby	194	29	cellular	cellular	JJ
cord-297078-pxggjaby	194	30	DNA	dna	NN
cord-297078-pxggjaby	194	31	replication	replication	NN
cord-297078-pxggjaby	194	32	.	.	.
cord-297078-pxggjaby	195	1	DNA	DNA	NNP
cord-297078-pxggjaby	195	2	virus	virus	NN
cord-297078-pxggjaby	195	3	-	-	HYPH
cord-297078-pxggjaby	195	4	derived	derive	VBN
cord-297078-pxggjaby	195	5	DNA	dna	NN
cord-297078-pxggjaby	195	6	replication	replication	NN
cord-297078-pxggjaby	195	7	could	could	MD
cord-297078-pxggjaby	195	8	have	have	VB
cord-297078-pxggjaby	195	9	been	be	VBN
cord-297078-pxggjaby	195	10	co	co	VBN
cord-297078-pxggjaby	195	11	-	-	VBN
cord-297078-pxggjaby	195	12	opted	opt	VBN
cord-297078-pxggjaby	195	13	concurrent	concurrent	JJ
cord-297078-pxggjaby	195	14	with	with	IN
cord-297078-pxggjaby	195	15	or	or	CC
cord-297078-pxggjaby	195	16	prior	prior	RB
cord-297078-pxggjaby	195	17	to	to	IN
cord-297078-pxggjaby	195	18	LUCA	LUCA	NNP
cord-297078-pxggjaby	195	19	,	,	,
cord-297078-pxggjaby	195	20	with	with	IN
cord-297078-pxggjaby	195	21	this	this	DT
cord-297078-pxggjaby	195	22	original	original	JJ
cord-297078-pxggjaby	195	23	apparatus	apparatus	NN
cord-297078-pxggjaby	195	24	being	be	VBG
cord-297078-pxggjaby	195	25	displaced	displace	VBN
cord-297078-pxggjaby	195	26	by	by	IN
cord-297078-pxggjaby	195	27	another	another	DT
cord-297078-pxggjaby	195	28	viral	viral	JJ
cord-297078-pxggjaby	195	29	apparatus	apparatus	NN
cord-297078-pxggjaby	195	30	in	in	IN
cord-297078-pxggjaby	195	31	one	one	CD
cord-297078-pxggjaby	195	32	lineage	lineage	NN
cord-297078-pxggjaby	195	33	after	after	IN
cord-297078-pxggjaby	195	34	divergence	divergence	NN
cord-297078-pxggjaby	195	35	of	of	IN
cord-297078-pxggjaby	195	36	bacteria	bacteria	NNS
cord-297078-pxggjaby	195	37	from	from	IN
cord-297078-pxggjaby	195	38	archaea	archaea	NNS
cord-297078-pxggjaby	195	39	/	/	SYM
cord-297078-pxggjaby	195	40	eukaryotes	eukaryote	NNS
cord-297078-pxggjaby	195	41	.	.	.
cord-297078-pxggjaby	196	1	Likewise	likewise	RB
cord-297078-pxggjaby	196	2	,	,	,
cord-297078-pxggjaby	196	3	this	this	DT
cord-297078-pxggjaby	196	4	could	could	MD
cord-297078-pxggjaby	196	5	have	have	VB
cord-297078-pxggjaby	196	6	happened	happen	VBN
cord-297078-pxggjaby	196	7	twice	twice	RB
cord-297078-pxggjaby	196	8	independently	independently	RB
cord-297078-pxggjaby	196	9	,	,	,
cord-297078-pxggjaby	196	10	post	post	VB
cord-297078-pxggjaby	196	11	-	-	NN
cord-297078-pxggjaby	196	12	LUCA	LUCA	NNP
cord-297078-pxggjaby	196	13	(	(	-LRB-
cord-297078-pxggjaby	196	14	Forterre	Forterre	NNP
cord-297078-pxggjaby	196	15	2001	2001	CD
cord-297078-pxggjaby	196	16	)	)	-RRB-
cord-297078-pxggjaby	196	17	.	.	.
cord-297078-pxggjaby	197	1	Forterre	Forterre	NNP
cord-297078-pxggjaby	197	2	's	's	POS
cord-297078-pxggjaby	197	3	hypothesis	hypothesis	NN
cord-297078-pxggjaby	197	4	,	,	,
cord-297078-pxggjaby	197	5	that	that	IN
cord-297078-pxggjaby	197	6	there	there	EX
cord-297078-pxggjaby	197	7	was	be	VBD
cord-297078-pxggjaby	197	8	'	'	``
cord-297078-pxggjaby	197	9	'	'	``
cord-297078-pxggjaby	197	10	arms	arm	NNS
cord-297078-pxggjaby	197	11	-	-	HYPH
cord-297078-pxggjaby	197	12	racedriven	racedriven	VBN
cord-297078-pxggjaby	197	13	coevolution	coevolution	NN
cord-297078-pxggjaby	197	14	of	of	IN
cord-297078-pxggjaby	197	15	cellular	cellular	JJ
cord-297078-pxggjaby	197	16	and	and	CC
cord-297078-pxggjaby	197	17	viral	viral	JJ
cord-297078-pxggjaby	197	18	genomes	genome	NNS
cord-297078-pxggjaby	197	19	'	'	''
cord-297078-pxggjaby	197	20	'	'	''
cord-297078-pxggjaby	197	21	(	(	-LRB-
cord-297078-pxggjaby	197	22	Forterre	Forterre	NNP
cord-297078-pxggjaby	197	23	2002	2002	CD
cord-297078-pxggjaby	197	24	)	)	-RRB-
cord-297078-pxggjaby	197	25	,	,	,
cord-297078-pxggjaby	197	26	where	where	WRB
cord-297078-pxggjaby	197	27	modified	modify	VBN
cord-297078-pxggjaby	197	28	forms	form	NNS
cord-297078-pxggjaby	197	29	of	of	IN
cord-297078-pxggjaby	197	30	nucleic	nucleic	JJ
cord-297078-pxggjaby	197	31	acids	acid	NNS
cord-297078-pxggjaby	197	32	evolved	evolve	VBN
cord-297078-pxggjaby	197	33	in	in	IN
cord-297078-pxggjaby	197	34	stepwise	stepwise	JJ
cord-297078-pxggjaby	197	35	fashion	fashion	NN
cord-297078-pxggjaby	197	36	in	in	IN
cord-297078-pxggjaby	197	37	viruses	virus	NNS
cord-297078-pxggjaby	197	38	to	to	TO
cord-297078-pxggjaby	197	39	evade	evade	VB
cord-297078-pxggjaby	197	40	host	host	NN
cord-297078-pxggjaby	197	41	'	'	''
cord-297078-pxggjaby	197	42	'	'	``
cord-297078-pxggjaby	197	43	immune	immune	NN
cord-297078-pxggjaby	197	44	'	'	''
cord-297078-pxggjaby	197	45	'	'	''
cord-297078-pxggjaby	197	46	systems	system	NNS
cord-297078-pxggjaby	197	47	,	,	,
cord-297078-pxggjaby	197	48	proposes	propose	VBZ
cord-297078-pxggjaby	197	49	that	that	IN
cord-297078-pxggjaby	197	50	deoxyribonucleotide	deoxyribonucleotide	JJ
cord-297078-pxggjaby	197	51	synthesis	synthesis	NN
cord-297078-pxggjaby	197	52	evolved	evolve	VBD
cord-297078-pxggjaby	197	53	first	first	RB
cord-297078-pxggjaby	197	54	in	in	IN
cord-297078-pxggjaby	197	55	viruses	virus	NNS
cord-297078-pxggjaby	197	56	,	,	,
cord-297078-pxggjaby	197	57	and	and	CC
cord-297078-pxggjaby	197	58	,	,	,
cord-297078-pxggjaby	197	59	importantly	importantly	RB
cord-297078-pxggjaby	197	60	,	,	,
cord-297078-pxggjaby	197	61	offers	offer	VBZ
cord-297078-pxggjaby	197	62	a	a	DT
cord-297078-pxggjaby	197	63	solution	solution	NN
cord-297078-pxggjaby	197	64	to	to	IN
cord-297078-pxggjaby	197	65	a	a	DT
cord-297078-pxggjaby	197	66	conflicting	conflicting	JJ
cord-297078-pxggjaby	197	67	aspect	aspect	NN
cord-297078-pxggjaby	197	68	of	of	IN
cord-297078-pxggjaby	197	69	polymerase	polymerase	NN
cord-297078-pxggjaby	197	70	relationships	relationship	NNS
cord-297078-pxggjaby	197	71	.	.	.
cord-297078-pxggjaby	198	1	Upon	upon	IN
cord-297078-pxggjaby	198	2	evolution	evolution	NN
cord-297078-pxggjaby	198	3	of	of	IN
cord-297078-pxggjaby	198	4	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	198	5	reduction	reduction	NN
cord-297078-pxggjaby	198	6	,	,	,
cord-297078-pxggjaby	198	7	the	the	DT
cord-297078-pxggjaby	198	8	simplest	simple	JJS
cord-297078-pxggjaby	198	9	explanation	explanation	NN
cord-297078-pxggjaby	198	10	in	in	IN
cord-297078-pxggjaby	198	11	terms	term	NNS
cord-297078-pxggjaby	198	12	of	of	IN
cord-297078-pxggjaby	198	13	their	-PRON-	PRP$
cord-297078-pxggjaby	198	14	use	use	NN
cord-297078-pxggjaby	198	15	in	in	IN
cord-297078-pxggjaby	198	16	replication	replication	NN
cord-297078-pxggjaby	198	17	of	of	IN
cord-297078-pxggjaby	198	18	genetic	genetic	JJ
cord-297078-pxggjaby	198	19	material	material	NN
cord-297078-pxggjaby	198	20	is	be	VBZ
cord-297078-pxggjaby	198	21	that	that	IN
cord-297078-pxggjaby	198	22	the	the	DT
cord-297078-pxggjaby	198	23	incumbent	incumbent	JJ
cord-297078-pxggjaby	198	24	polymerase	polymerase	NN
cord-297078-pxggjaby	198	25	incorporated	incorporate	VBN
cord-297078-pxggjaby	198	26	deoxyribonucleotide	deoxyribonucleotide	JJ
cord-297078-pxggjaby	198	27	precursors	precursor	NNS
cord-297078-pxggjaby	198	28	.	.	.
cord-297078-pxggjaby	199	1	Substrate	substrate	NN
cord-297078-pxggjaby	199	2	and	and	CC
cord-297078-pxggjaby	199	3	template	template	NN
cord-297078-pxggjaby	199	4	selectivity	selectivity	NN
cord-297078-pxggjaby	199	5	,	,	,
cord-297078-pxggjaby	199	6	where	where	WRB
cord-297078-pxggjaby	199	7	studied	study	VBN
cord-297078-pxggjaby	199	8	,	,	,
cord-297078-pxggjaby	199	9	appears	appear	VBZ
cord-297078-pxggjaby	199	10	to	to	TO
cord-297078-pxggjaby	199	11	be	be	VB
cord-297078-pxggjaby	199	12	easily	easily	RB
cord-297078-pxggjaby	199	13	altered	alter	VBN
cord-297078-pxggjaby	199	14	-	-	HYPH
cord-297078-pxggjaby	199	15	single	single	JJ
cord-297078-pxggjaby	199	16	residues	residue	NNS
cord-297078-pxggjaby	199	17	are	be	VBP
cord-297078-pxggjaby	199	18	responsible	responsible	JJ
cord-297078-pxggjaby	199	19	for	for	IN
cord-297078-pxggjaby	199	20	substrate	substrate	JJ
cord-297078-pxggjaby	199	21	selectivity	selectivity	NN
cord-297078-pxggjaby	199	22	in	in	IN
cord-297078-pxggjaby	199	23	E.	E.	NNP
cord-297078-pxggjaby	199	24	coli	coli	NNS
cord-297078-pxggjaby	200	1	DNA	dna	NN
cord-297078-pxggjaby	200	2	pol	pol	NN
cord-297078-pxggjaby	200	3	I	i	NN
cord-297078-pxggjaby	200	4	(	(	-LRB-
cord-297078-pxggjaby	200	5	Astatke	Astatke	NNP
cord-297078-pxggjaby	200	6	et	et	FW
cord-297078-pxggjaby	200	7	al	al	NNP
cord-297078-pxggjaby	200	8	.	.	NNP
cord-297078-pxggjaby	200	9	1998	1998	CD
cord-297078-pxggjaby	200	10	)	)	-RRB-
cord-297078-pxggjaby	200	11	and	and	CC
cord-297078-pxggjaby	200	12	reverse	reverse	VB
cord-297078-pxggjaby	200	13	transcriptase	transcriptase	NN
cord-297078-pxggjaby	200	14	(	(	-LRB-
cord-297078-pxggjaby	200	15	Gao	Gao	NNP
cord-297078-pxggjaby	200	16	et	et	NNP
cord-297078-pxggjaby	200	17	al	al	NNP
cord-297078-pxggjaby	200	18	.	.	.
cord-297078-pxggjaby	200	19	1997	1997	CD
cord-297078-pxggjaby	200	20	)	)	-RRB-
cord-297078-pxggjaby	200	21	,	,	,
cord-297078-pxggjaby	200	22	and	and	CC
cord-297078-pxggjaby	200	23	the	the	DT
cord-297078-pxggjaby	200	24	RNA	RNA	NNP
cord-297078-pxggjaby	200	25	-	-	HYPH
cord-297078-pxggjaby	200	26	dependent	dependent	JJ
cord-297078-pxggjaby	200	27	RNA	RNA	NNP
cord-297078-pxggjaby	200	28	polymerase	polymerase	NN
cord-297078-pxggjaby	200	29	from	from	IN
cord-297078-pxggjaby	200	30	Brome	Brome	NNP
cord-297078-pxggjaby	200	31	Mosaic	Mosaic	NNP
cord-297078-pxggjaby	200	32	Virus	Virus	NNP
cord-297078-pxggjaby	200	33	will	will	MD
cord-297078-pxggjaby	200	34	accept	accept	VB
cord-297078-pxggjaby	200	35	both	both	CC
cord-297078-pxggjaby	200	36	DNA	DNA	NNP
cord-297078-pxggjaby	200	37	and	and	CC
cord-297078-pxggjaby	200	38	RNA	RNA	NNP
cord-297078-pxggjaby	200	39	-	-	HYPH
cord-297078-pxggjaby	200	40	DNA	dna	NN
cord-297078-pxggjaby	200	41	hybrid	hybrid	NN
cord-297078-pxggjaby	200	42	templates	template	NNS
cord-297078-pxggjaby	200	43	(	(	-LRB-
cord-297078-pxggjaby	200	44	Siegel	Siegel	NNP
cord-297078-pxggjaby	200	45	et	et	NNP
cord-297078-pxggjaby	200	46	al	al	NNP
cord-297078-pxggjaby	200	47	.	.	.
cord-297078-pxggjaby	200	48	1999	1999	CD
cord-297078-pxggjaby	200	49	)	)	-RRB-
cord-297078-pxggjaby	200	50	.	.	.
cord-297078-pxggjaby	201	1	If	if	IN
cord-297078-pxggjaby	201	2	,	,	,
cord-297078-pxggjaby	201	3	as	as	IN
cord-297078-pxggjaby	201	4	per	per	IN
cord-297078-pxggjaby	201	5	Scenario	scenario	NN
cord-297078-pxggjaby	201	6	1	1	CD
cord-297078-pxggjaby	201	7	above	above	RB
cord-297078-pxggjaby	201	8	,	,	,
cord-297078-pxggjaby	201	9	there	there	EX
cord-297078-pxggjaby	201	10	had	have	VBD
cord-297078-pxggjaby	201	11	been	be	VBN
cord-297078-pxggjaby	201	12	only	only	RB
cord-297078-pxggjaby	201	13	one	one	CD
cord-297078-pxggjaby	201	14	NOGD	NOGD	NNP
cord-297078-pxggjaby	201	15	from	from	IN
cord-297078-pxggjaby	201	16	a	a	DT
cord-297078-pxggjaby	201	17	viral	viral	JJ
cord-297078-pxggjaby	201	18	source	source	NN
cord-297078-pxggjaby	201	19	,	,	,
cord-297078-pxggjaby	201	20	one	one	PRP
cord-297078-pxggjaby	201	21	would	would	MD
cord-297078-pxggjaby	201	22	expect	expect	VB
cord-297078-pxggjaby	201	23	an	an	DT
cord-297078-pxggjaby	201	24	evolutionary	evolutionary	JJ
cord-297078-pxggjaby	201	25	relationship	relationship	NN
cord-297078-pxggjaby	201	26	between	between	IN
cord-297078-pxggjaby	201	27	modern	modern	JJ
cord-297078-pxggjaby	201	28	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	201	29	RNA	RNA	NNP
cord-297078-pxggjaby	201	30	polymerases	polymerase	NNS
cord-297078-pxggjaby	201	31	and	and	CC
cord-297078-pxggjaby	201	32	one	one	CD
cord-297078-pxggjaby	201	33	family	family	NN
cord-297078-pxggjaby	201	34	of	of	IN
cord-297078-pxggjaby	201	35	replicative	replicative	JJ
cord-297078-pxggjaby	201	36	DNA	dna	NN
cord-297078-pxggjaby	201	37	polymerases	polymerase	NNS
cord-297078-pxggjaby	201	38	.	.	.
cord-297078-pxggjaby	202	1	However	however	RB
cord-297078-pxggjaby	202	2	,	,	,
cord-297078-pxggjaby	202	3	this	this	DT
cord-297078-pxggjaby	202	4	is	be	VBZ
cord-297078-pxggjaby	202	5	not	not	RB
cord-297078-pxggjaby	202	6	the	the	DT
cord-297078-pxggjaby	202	7	case	case	NN
cord-297078-pxggjaby	202	8	.	.	.
cord-297078-pxggjaby	203	1	DNA	dna	NN
cord-297078-pxggjaby	203	2	polymerase	polymerase	NN
cord-297078-pxggjaby	203	3	III	iii	CD
cord-297078-pxggjaby	204	1	(	(	-LRB-
cord-297078-pxggjaby	204	2	C	c	NN
cord-297078-pxggjaby	204	3	-	-	HYPH
cord-297078-pxggjaby	204	4	family	family	NN
cord-297078-pxggjaby	204	5	polymerases	polymerase	NNS
cord-297078-pxggjaby	204	6	)	)	-RRB-
cord-297078-pxggjaby	204	7	,	,	,
cord-297078-pxggjaby	204	8	the	the	DT
cord-297078-pxggjaby	204	9	replicative	replicative	JJ
cord-297078-pxggjaby	204	10	polymerase	polymerase	NN
cord-297078-pxggjaby	204	11	in	in	IN
cord-297078-pxggjaby	204	12	bacteria	bacteria	NNS
cord-297078-pxggjaby	204	13	,	,	,
cord-297078-pxggjaby	204	14	is	be	VBZ
cord-297078-pxggjaby	204	15	unrelated	unrelated	JJ
cord-297078-pxggjaby	204	16	to	to	TO
cord-297078-pxggjaby	204	17	modern	modern	JJ
cord-297078-pxggjaby	204	18	archaeal	archaeal	JJ
cord-297078-pxggjaby	204	19	-	-	HYPH
cord-297078-pxggjaby	204	20	and	and	CC
cord-297078-pxggjaby	204	21	eukaryotic	eukaryotic	JJ
cord-297078-pxggjaby	204	22	-	-	HYPH
cord-297078-pxggjaby	204	23	replicative	replicative	JJ
cord-297078-pxggjaby	204	24	DNA	dna	NN
cord-297078-pxggjaby	204	25	polymerases	polymerase	NNS
cord-297078-pxggjaby	204	26	(	(	-LRB-
cord-297078-pxggjaby	204	27	which	which	WDT
cord-297078-pxggjaby	204	28	are	be	VBP
cord-297078-pxggjaby	204	29	B	b	NN
cord-297078-pxggjaby	204	30	-	-	HYPH
cord-297078-pxggjaby	204	31	family	family	NN
cord-297078-pxggjaby	204	32	polymerases	polymerase	NNS
cord-297078-pxggjaby	204	33	)	)	-RRB-
cord-297078-pxggjaby	204	34	and	and	CC
cord-297078-pxggjaby	204	35	neither	neither	DT
cord-297078-pxggjaby	204	36	are	be	VBP
cord-297078-pxggjaby	204	37	related	relate	VBN
cord-297078-pxggjaby	204	38	to	to	IN
cord-297078-pxggjaby	204	39	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	204	40	RNA	RNA	NNP
cord-297078-pxggjaby	204	41	polymerases	polymerase	NNS
cord-297078-pxggjaby	204	42	(	(	-LRB-
cord-297078-pxggjaby	204	43	Ito	Ito	NNP
cord-297078-pxggjaby	204	44	and	and	CC
cord-297078-pxggjaby	204	45	Braithwaite	Braithwaite	NNP
cord-297078-pxggjaby	204	46	1991	1991	CD
cord-297078-pxggjaby	204	47	;	;	:
cord-297078-pxggjaby	204	48	Steitz	steitz	NN
cord-297078-pxggjaby	204	49	1999	1999	CD
cord-297078-pxggjaby	204	50	;	;	:
cord-297078-pxggjaby	204	51	Cramer	Cramer	NNP
cord-297078-pxggjaby	204	52	2002b	2002b	CD
cord-297078-pxggjaby	204	53	;	;	:
cord-297078-pxggjaby	204	54	Grabowski	Grabowski	NNP
cord-297078-pxggjaby	204	55	and	and	CC
cord-297078-pxggjaby	204	56	Kelman	Kelman	NNP
cord-297078-pxggjaby	204	57	2003	2003	CD
cord-297078-pxggjaby	204	58	)	)	-RRB-
cord-297078-pxggjaby	204	59	.	.	.
cord-297078-pxggjaby	205	1	In	in	IN
cord-297078-pxggjaby	205	2	contrast	contrast	NN
cord-297078-pxggjaby	205	3	,	,	,
cord-297078-pxggjaby	205	4	the	the	DT
cord-297078-pxggjaby	205	5	palm	palm	NN
cord-297078-pxggjaby	205	6	domain	domain	NN
cord-297078-pxggjaby	205	7	of	of	IN
cord-297078-pxggjaby	205	8	A	a	DT
cord-297078-pxggjaby	205	9	-	-	HYPH
cord-297078-pxggjaby	205	10	family	family	NN
cord-297078-pxggjaby	205	11	DNA	dna	NN
cord-297078-pxggjaby	205	12	polymerases	polymerase	NNS
cord-297078-pxggjaby	205	13	shows	show	VBZ
cord-297078-pxggjaby	205	14	structural	structural	JJ
cord-297078-pxggjaby	205	15	homology	homology	NN
cord-297078-pxggjaby	205	16	to	to	IN
cord-297078-pxggjaby	205	17	the	the	DT
cord-297078-pxggjaby	205	18	equivalent	equivalent	JJ
cord-297078-pxggjaby	205	19	domains	domain	NNS
cord-297078-pxggjaby	205	20	of	of	IN
cord-297078-pxggjaby	205	21	several	several	JJ
cord-297078-pxggjaby	205	22	RNA	RNA	NNP
cord-297078-pxggjaby	205	23	-	-	HYPH
cord-297078-pxggjaby	205	24	dependent	dependent	JJ
cord-297078-pxggjaby	205	25	RNA	RNA	NNP
cord-297078-pxggjaby	205	26	polymerases	polymerase	NNS
cord-297078-pxggjaby	205	27	,	,	,
cord-297078-pxggjaby	205	28	reverse	reverse	VB
cord-297078-pxggjaby	205	29	transcriptases	transcriptase	NNS
cord-297078-pxggjaby	205	30	,	,	,
cord-297078-pxggjaby	205	31	and	and	CC
cord-297078-pxggjaby	205	32	DNA	dna	NN
cord-297078-pxggjaby	205	33	-	-	HYPH
cord-297078-pxggjaby	205	34	dependent	dependent	JJ
cord-297078-pxggjaby	205	35	RNA	RNA	NNP
cord-297078-pxggjaby	205	36	polymerases	polymerase	NNS
cord-297078-pxggjaby	205	37	(	(	-LRB-
cord-297078-pxggjaby	205	38	Hansen	Hansen	NNP
cord-297078-pxggjaby	205	39	,	,	,
cord-297078-pxggjaby	205	40	Long	Long	NNP
cord-297078-pxggjaby	205	41	,	,	,
cord-297078-pxggjaby	205	42	and	and	CC
cord-297078-pxggjaby	205	43	Schultz	Schultz	NNP
cord-297078-pxggjaby	205	44	1997	1997	CD
cord-297078-pxggjaby	205	45	;	;	:
cord-297078-pxggjaby	205	46	Steitz	Steitz	NNP
cord-297078-pxggjaby	205	47	1999	1999	CD
cord-297078-pxggjaby	205	48	)	)	-RRB-
cord-297078-pxggjaby	205	49	.	.	.
cord-297078-pxggjaby	206	1	This	this	DT
cord-297078-pxggjaby	206	2	speaks	speak	VBZ
cord-297078-pxggjaby	206	3	in	in	IN
cord-297078-pxggjaby	206	4	favor	favor	NN
cord-297078-pxggjaby	206	5	of	of	IN
cord-297078-pxggjaby	206	6	a	a	DT
cord-297078-pxggjaby	206	7	viral	viral	JJ
cord-297078-pxggjaby	206	8	origin	origin	NN
cord-297078-pxggjaby	206	9	for	for	IN
cord-297078-pxggjaby	206	10	deoxyribonucleotide	deoxyribonucleotide	JJ
cord-297078-pxggjaby	206	11	syntheses	synthesis	NNS
cord-297078-pxggjaby	206	12	in	in	IN
cord-297078-pxggjaby	206	13	so	so	RB
cord-297078-pxggjaby	206	14	far	far	RB
cord-297078-pxggjaby	206	15	as	as	IN
cord-297078-pxggjaby	206	16	it	-PRON-	PRP
cord-297078-pxggjaby	206	17	is	be	VBZ
cord-297078-pxggjaby	206	18	possible	possible	JJ
cord-297078-pxggjaby	206	19	to	to	TO
cord-297078-pxggjaby	206	20	envisage	envisage	VB
cord-297078-pxggjaby	206	21	deoxyribonucleotide	deoxyribonucleotide	NNP
cord-297078-pxggjaby	206	22	'	'	''
cord-297078-pxggjaby	206	23	'	'	``
cord-297078-pxggjaby	206	24	takeover	takeover	NN
cord-297078-pxggjaby	206	25	'	'	''
cord-297078-pxggjaby	206	26	'	'	''
cord-297078-pxggjaby	206	27	in	in	IN
cord-297078-pxggjaby	206	28	an	an	DT
cord-297078-pxggjaby	206	29	RNA	RNA	NNP
cord-297078-pxggjaby	206	30	virus	virus	NN
cord-297078-pxggjaby	206	31	.	.	.
cord-297078-pxggjaby	207	1	These	these	DT
cord-297078-pxggjaby	207	2	polymerases	polymerase	NNS
cord-297078-pxggjaby	207	3	are	be	VBP
cord-297078-pxggjaby	207	4	nevertheless	nevertheless	RB
cord-297078-pxggjaby	207	5	too	too	RB
cord-297078-pxggjaby	207	6	far	far	RB
cord-297078-pxggjaby	207	7	diverged	diverged	JJ
cord-297078-pxggjaby	207	8	to	to	TO
cord-297078-pxggjaby	207	9	be	be	VB
cord-297078-pxggjaby	207	10	useful	useful	JJ
cord-297078-pxggjaby	207	11	for	for	IN
cord-297078-pxggjaby	207	12	phylogenetic	phylogenetic	JJ
cord-297078-pxggjaby	207	13	studies	study	NNS
cord-297078-pxggjaby	207	14	,	,	,
cord-297078-pxggjaby	207	15	and	and	CC
cord-297078-pxggjaby	207	16	on	on	IN
cord-297078-pxggjaby	207	17	sequence	sequence	NN
cord-297078-pxggjaby	207	18	alone	alone	RB
cord-297078-pxggjaby	207	19	,	,	,
cord-297078-pxggjaby	207	20	it	-PRON-	PRP
cord-297078-pxggjaby	207	21	is	be	VBZ
cord-297078-pxggjaby	207	22	not	not	RB
cord-297078-pxggjaby	207	23	possible	possible	JJ
cord-297078-pxggjaby	207	24	to	to	TO
cord-297078-pxggjaby	207	25	show	show	VB
cord-297078-pxggjaby	207	26	an	an	DT
cord-297078-pxggjaby	207	27	evolutionary	evolutionary	JJ
cord-297078-pxggjaby	207	28	relationship	relationship	NN
cord-297078-pxggjaby	207	29	between	between	IN
cord-297078-pxggjaby	207	30	RNA	RNA	NNP
cord-297078-pxggjaby	207	31	-	-	HYPH
cord-297078-pxggjaby	207	32	dependent	dependent	JJ
cord-297078-pxggjaby	207	33	RNA	RNA	NNP
cord-297078-pxggjaby	207	34	polymerases	polymerase	NNS
cord-297078-pxggjaby	207	35	and	and	CC
cord-297078-pxggjaby	207	36	reverse	reverse	VB
cord-297078-pxggjaby	207	37	transcriptases	transcriptase	NNS
cord-297078-pxggjaby	207	38	(	(	-LRB-
cord-297078-pxggjaby	207	39	Zanotto	Zanotto	NNP
cord-297078-pxggjaby	207	40	et	et	NNP
cord-297078-pxggjaby	207	41	al	al	NNP
cord-297078-pxggjaby	207	42	.	.	.
cord-297078-pxggjaby	207	43	1996	1996	CD
cord-297078-pxggjaby	207	44	)	)	-RRB-
cord-297078-pxggjaby	207	45	.	.	.
cord-297078-pxggjaby	208	1	Furthermore	furthermore	RB
cord-297078-pxggjaby	208	2	,	,	,
cord-297078-pxggjaby	208	3	while	while	IN
cord-297078-pxggjaby	208	4	the	the	DT
cord-297078-pxggjaby	208	5	palm	palm	NN
cord-297078-pxggjaby	208	6	domains	domain	NNS
cord-297078-pxggjaby	208	7	appear	appear	VBP
cord-297078-pxggjaby	208	8	homologous	homologous	JJ
cord-297078-pxggjaby	208	9	,	,	,
cord-297078-pxggjaby	208	10	the	the	DT
cord-297078-pxggjaby	208	11	finger	finger	NN
cord-297078-pxggjaby	208	12	and	and	CC
cord-297078-pxggjaby	208	13	thumb	thumb	NN
cord-297078-pxggjaby	208	14	domains	domain	NNS
cord-297078-pxggjaby	208	15	are	be	VBP
cord-297078-pxggjaby	208	16	not	not	RB
cord-297078-pxggjaby	208	17	(	(	-LRB-
cord-297078-pxggjaby	208	18	Hansen	Hansen	NNP
cord-297078-pxggjaby	208	19	,	,	,
cord-297078-pxggjaby	208	20	Long	Long	NNP
cord-297078-pxggjaby	208	21	,	,	,
cord-297078-pxggjaby	208	22	and	and	CC
cord-297078-pxggjaby	208	23	Schultz	Schultz	NNP
cord-297078-pxggjaby	208	24	1997	1997	CD
cord-297078-pxggjaby	208	25	;	;	:
cord-297078-pxggjaby	208	26	Steitz	Steitz	NNP
cord-297078-pxggjaby	208	27	1999	1999	CD
cord-297078-pxggjaby	208	28	)	)	-RRB-
cord-297078-pxggjaby	208	29	.	.	.
cord-297078-pxggjaby	209	1	The	the	DT
cord-297078-pxggjaby	209	2	existence	existence	NN
cord-297078-pxggjaby	209	3	of	of	IN
cord-297078-pxggjaby	209	4	a	a	DT
cord-297078-pxggjaby	209	5	range	range	NN
cord-297078-pxggjaby	209	6	of	of	IN
cord-297078-pxggjaby	209	7	prereplicatively	prereplicatively	RB
cord-297078-pxggjaby	209	8	modified	modify	VBN
cord-297078-pxggjaby	209	9	deoxyribonucleotides	deoxyribonucleotide	NNS
cord-297078-pxggjaby	209	10	in	in	IN
cord-297078-pxggjaby	209	11	DNA	dna	NN
cord-297078-pxggjaby	209	12	viruses	virus	NNS
cord-297078-pxggjaby	209	13	does	do	VBZ
cord-297078-pxggjaby	209	14	,	,	,
cord-297078-pxggjaby	209	15	however	however	RB
cord-297078-pxggjaby	209	16	,	,	,
cord-297078-pxggjaby	209	17	provide	provide	VB
cord-297078-pxggjaby	209	18	a	a	DT
cord-297078-pxggjaby	209	19	modern	modern	JJ
cord-297078-pxggjaby	209	20	precedent	precedent	NN
cord-297078-pxggjaby	209	21	for	for	IN
cord-297078-pxggjaby	209	22	Forterre	Forterre	NNP
cord-297078-pxggjaby	209	23	's	's	POS
cord-297078-pxggjaby	209	24	hypothesis	hypothesis	NN
cord-297078-pxggjaby	209	25	(	(	-LRB-
cord-297078-pxggjaby	209	26	examples	example	NNS
cord-297078-pxggjaby	209	27	being	be	VBG
cord-297078-pxggjaby	209	28	hydroxymethyluracil	hydroxymethyluracil	NNP
cord-297078-pxggjaby	209	29	instead	instead	RB
cord-297078-pxggjaby	209	30	of	of	IN
cord-297078-pxggjaby	209	31	T	T	NNP
cord-297078-pxggjaby	209	32	in	in	IN
cord-297078-pxggjaby	209	33	SP01	SP01	NNP
cord-297078-pxggjaby	209	34	,	,	,
cord-297078-pxggjaby	209	35	U	u	VB
cord-297078-pxggjaby	209	36	instead	instead	RB
cord-297078-pxggjaby	209	37	of	of	IN
cord-297078-pxggjaby	209	38	T	T	NNP
cord-297078-pxggjaby	209	39	in	in	IN
cord-297078-pxggjaby	209	40	PBS1	PBS1	NNP
cord-297078-pxggjaby	209	41	and	and	CC
cord-297078-pxggjaby	209	42	PBS2	PBS2	NNP
cord-297078-pxggjaby	209	43	,	,	,
cord-297078-pxggjaby	209	44	hydroxymethylcytosine	hydroxymethylcytosine	VB
cord-297078-pxggjaby	209	45	instead	instead	RB
cord-297078-pxggjaby	209	46	of	of	IN
cord-297078-pxggjaby	209	47	C	C	NNP
cord-297078-pxggjaby	209	48	in	in	IN
cord-297078-pxggjaby	209	49	T	T	NNP
cord-297078-pxggjaby	209	50	-	-	HYPH
cord-297078-pxggjaby	209	51	even	even	RB
cord-297078-pxggjaby	209	52	phage	phage	NN
cord-297078-pxggjaby	209	53	,	,	,
cord-297078-pxggjaby	209	54	and	and	CC
cord-297078-pxggjaby	209	55	2-aminoadenine	2-aminoadenine	CD
cord-297078-pxggjaby	209	56	instead	instead	RB
cord-297078-pxggjaby	209	57	of	of	IN
cord-297078-pxggjaby	209	58	A	a	DT
cord-297078-pxggjaby	209	59	in	in	IN
cord-297078-pxggjaby	209	60	cyanophage	cyanophage	NN
cord-297078-pxggjaby	210	1	S-2L	S-2L	NNP
cord-297078-pxggjaby	210	2	-	-	HYPH
cord-297078-pxggjaby	210	3	see	see	VB
cord-297078-pxggjaby	210	4	Kornberg	Kornberg	NNP
cord-297078-pxggjaby	210	5	and	and	CC
cord-297078-pxggjaby	210	6	Baker	Baker	NNP
cord-297078-pxggjaby	210	7	(	(	-LRB-
cord-297078-pxggjaby	210	8	1992	1992	CD
cord-297078-pxggjaby	210	9	)	)	-RRB-
cord-297078-pxggjaby	210	10	.	.	.
cord-297078-pxggjaby	211	1	The	the	DT
cord-297078-pxggjaby	211	2	lack	lack	NN
cord-297078-pxggjaby	211	3	of	of	IN
cord-297078-pxggjaby	211	4	homology	homology	NN
cord-297078-pxggjaby	211	5	between	between	IN
cord-297078-pxggjaby	211	6	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	211	7	RNA	RNA	NNP
cord-297078-pxggjaby	211	8	polymerases	polymerase	NNS
cord-297078-pxggjaby	211	9	and	and	CC
cord-297078-pxggjaby	211	10	the	the	DT
cord-297078-pxggjaby	211	11	two	two	CD
cord-297078-pxggjaby	211	12	unrelated	unrelated	JJ
cord-297078-pxggjaby	211	13	families	family	NNS
cord-297078-pxggjaby	211	14	of	of	IN
cord-297078-pxggjaby	211	15	replicative	replicative	JJ
cord-297078-pxggjaby	211	16	DNA	dna	NN
cord-297078-pxggjaby	211	17	polymerase	polymerase	NN
cord-297078-pxggjaby	211	18	makes	make	VBZ
cord-297078-pxggjaby	211	19	it	-PRON-	PRP
cord-297078-pxggjaby	211	20	difficult	difficult	JJ
cord-297078-pxggjaby	211	21	to	to	TO
cord-297078-pxggjaby	211	22	establish	establish	VB
cord-297078-pxggjaby	211	23	the	the	DT
cord-297078-pxggjaby	211	24	details	detail	NNS
cord-297078-pxggjaby	211	25	of	of	IN
cord-297078-pxggjaby	211	26	the	the	DT
cord-297078-pxggjaby	211	27	RNA	RNA	NNP
cord-297078-pxggjaby	211	28	to	to	IN
cord-297078-pxggjaby	211	29	DNA	dna	NN
cord-297078-pxggjaby	211	30	transition	transition	NN
cord-297078-pxggjaby	211	31	.	.	.
cord-297078-pxggjaby	212	1	It	-PRON-	PRP
cord-297078-pxggjaby	212	2	is	be	VBZ
cord-297078-pxggjaby	212	3	possible	possible	JJ
cord-297078-pxggjaby	212	4	that	that	IN
cord-297078-pxggjaby	212	5	this	this	DT
cord-297078-pxggjaby	212	6	transition	transition	NN
cord-297078-pxggjaby	212	7	occurred	occur	VBD
cord-297078-pxggjaby	212	8	in	in	IN
cord-297078-pxggjaby	212	9	cells	cell	NNS
cord-297078-pxggjaby	212	10	,	,	,
cord-297078-pxggjaby	212	11	with	with	IN
cord-297078-pxggjaby	212	12	DNA	dna	NN
cord-297078-pxggjaby	212	13	being	being	NN
cord-297078-pxggjaby	212	14	initially	initially	RB
cord-297078-pxggjaby	212	15	replicated	replicate	VBN
cord-297078-pxggjaby	212	16	by	by	IN
cord-297078-pxggjaby	212	17	the	the	DT
cord-297078-pxggjaby	212	18	ancestor	ancestor	NN
cord-297078-pxggjaby	212	19	of	of	IN
cord-297078-pxggjaby	212	20	the	the	DT
cord-297078-pxggjaby	212	21	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	212	22	RNA	RNA	NNP
cord-297078-pxggjaby	212	23	polymerases	polymerase	NNS
cord-297078-pxggjaby	212	24	.	.	.
cord-297078-pxggjaby	213	1	However	however	RB
cord-297078-pxggjaby	213	2	,	,	,
cord-297078-pxggjaby	213	3	this	this	DT
cord-297078-pxggjaby	213	4	scenario	scenario	NN
cord-297078-pxggjaby	213	5	introduces	introduce	VBZ
cord-297078-pxggjaby	213	6	a	a	DT
cord-297078-pxggjaby	213	7	third	third	JJ
cord-297078-pxggjaby	213	8	step	step	NN
cord-297078-pxggjaby	213	9	,	,	,
cord-297078-pxggjaby	213	10	for	for	IN
cord-297078-pxggjaby	213	11	which	which	WDT
cord-297078-pxggjaby	213	12	there	there	EX
cord-297078-pxggjaby	213	13	is	be	VBZ
cord-297078-pxggjaby	213	14	no	no	DT
cord-297078-pxggjaby	213	15	evidence	evidence	NN
cord-297078-pxggjaby	213	16	.	.	.
cord-297078-pxggjaby	214	1	Under	under	IN
cord-297078-pxggjaby	214	2	Scenarios	scenario	NNS
cord-297078-pxggjaby	214	3	1	1	CD
cord-297078-pxggjaby	214	4	and	and	CC
cord-297078-pxggjaby	214	5	2	2	CD
cord-297078-pxggjaby	214	6	above	above	RB
cord-297078-pxggjaby	214	7	,	,	,
cord-297078-pxggjaby	214	8	RNA	RNA	NNP
cord-297078-pxggjaby	214	9	repair	repair	NN
cord-297078-pxggjaby	214	10	could	could	MD
cord-297078-pxggjaby	214	11	have	have	VB
cord-297078-pxggjaby	214	12	been	be	VBN
cord-297078-pxggjaby	214	13	a	a	DT
cord-297078-pxggjaby	214	14	feature	feature	NN
cord-297078-pxggjaby	214	15	of	of	IN
cord-297078-pxggjaby	214	16	the	the	DT
cord-297078-pxggjaby	214	17	LUCA	LUCA	NNP
cord-297078-pxggjaby	214	18	but	but	CC
cord-297078-pxggjaby	214	19	clearly	clearly	RB
cord-297078-pxggjaby	214	20	in	in	IN
cord-297078-pxggjaby	214	21	different	different	JJ
cord-297078-pxggjaby	214	22	capacities	capacity	NNS
cord-297078-pxggjaby	214	23	.	.	.
cord-297078-pxggjaby	215	1	Under	under	IN
cord-297078-pxggjaby	215	2	Scenario	Scenario	NNP
cord-297078-pxggjaby	215	3	1	1	CD
cord-297078-pxggjaby	215	4	,	,	,
cord-297078-pxggjaby	215	5	a	a	DT
cord-297078-pxggjaby	215	6	DNA	dna	NN
cord-297078-pxggjaby	215	7	-	-	HYPH
cord-297078-pxggjaby	215	8	based	base	VBN
cord-297078-pxggjaby	215	9	LUCA	LUCA	NNP
cord-297078-pxggjaby	215	10	,	,	,
cord-297078-pxggjaby	215	11	the	the	DT
cord-297078-pxggjaby	215	12	only	only	JJ
cord-297078-pxggjaby	215	13	possible	possible	JJ
cord-297078-pxggjaby	215	14	function	function	NN
cord-297078-pxggjaby	215	15	for	for	IN
cord-297078-pxggjaby	215	16	RNA	RNA	NNP
cord-297078-pxggjaby	215	17	repair	repair	NN
cord-297078-pxggjaby	215	18	would	would	MD
cord-297078-pxggjaby	215	19	be	be	VB
cord-297078-pxggjaby	215	20	the	the	DT
cord-297078-pxggjaby	215	21	modern	modern	JJ
cord-297078-pxggjaby	215	22	one	one	NN
cord-297078-pxggjaby	215	23	;	;	:
cord-297078-pxggjaby	215	24	mRNA	mrna	NN
cord-297078-pxggjaby	215	25	quality	quality	NN
cord-297078-pxggjaby	215	26	control	control	NN
cord-297078-pxggjaby	215	27	.	.	.
cord-297078-pxggjaby	216	1	Genomic	Genomic	NNP
cord-297078-pxggjaby	216	2	RNA	RNA	NNP
cord-297078-pxggjaby	216	3	repair	repair	NN
cord-297078-pxggjaby	216	4	by	by	IN
cord-297078-pxggjaby	216	5	this	this	DT
cord-297078-pxggjaby	216	6	route	route	NN
cord-297078-pxggjaby	216	7	may	may	MD
cord-297078-pxggjaby	216	8	have	have	VB
cord-297078-pxggjaby	216	9	been	be	VBN
cord-297078-pxggjaby	216	10	a	a	DT
cord-297078-pxggjaby	216	11	feature	feature	NN
cord-297078-pxggjaby	216	12	of	of	IN
cord-297078-pxggjaby	216	13	an	an	DT
cord-297078-pxggjaby	216	14	earlier	early	JJR
cord-297078-pxggjaby	216	15	stage	stage	NN
cord-297078-pxggjaby	216	16	in	in	IN
cord-297078-pxggjaby	216	17	life	life	NN
cord-297078-pxggjaby	216	18	,	,	,
cord-297078-pxggjaby	216	19	prior	prior	RB
cord-297078-pxggjaby	216	20	to	to	IN
cord-297078-pxggjaby	216	21	the	the	DT
cord-297078-pxggjaby	216	22	RNA	RNA	NNP
cord-297078-pxggjaby	216	23	to	to	IN
cord-297078-pxggjaby	216	24	DNA	dna	NN
cord-297078-pxggjaby	216	25	transition	transition	NN
cord-297078-pxggjaby	216	26	,	,	,
cord-297078-pxggjaby	216	27	but	but	CC
cord-297078-pxggjaby	216	28	it	-PRON-	PRP
cord-297078-pxggjaby	216	29	would	would	MD
cord-297078-pxggjaby	216	30	obviously	obviously	RB
cord-297078-pxggjaby	216	31	not	not	RB
cord-297078-pxggjaby	216	32	have	have	VB
cord-297078-pxggjaby	216	33	been	be	VBN
cord-297078-pxggjaby	216	34	a	a	DT
cord-297078-pxggjaby	216	35	feature	feature	NN
cord-297078-pxggjaby	216	36	of	of	IN
cord-297078-pxggjaby	216	37	LUCA	LUCA	NNP
cord-297078-pxggjaby	216	38	.	.	.
cord-297078-pxggjaby	217	1	Under	under	IN
cord-297078-pxggjaby	217	2	Scenario	Scenario	NNP
cord-297078-pxggjaby	217	3	2	2	CD
cord-297078-pxggjaby	217	4	,	,	,
cord-297078-pxggjaby	217	5	the	the	DT
cord-297078-pxggjaby	217	6	LUCA	LUCA	NNP
cord-297078-pxggjaby	217	7	possessed	possess	VBD
cord-297078-pxggjaby	217	8	an	an	DT
cord-297078-pxggjaby	217	9	RNA	RNA	NNP
cord-297078-pxggjaby	217	10	genome	genome	NN
cord-297078-pxggjaby	217	11	,	,	,
cord-297078-pxggjaby	217	12	and	and	CC
cord-297078-pxggjaby	217	13	if	if	IN
cord-297078-pxggjaby	217	14	the	the	DT
cord-297078-pxggjaby	217	15	inherent	inherent	JJ
cord-297078-pxggjaby	217	16	potential	potential	NN
cord-297078-pxggjaby	217	17	for	for	IN
cord-297078-pxggjaby	217	18	RNA	RNA	NNP
cord-297078-pxggjaby	217	19	repair	repair	NN
cord-297078-pxggjaby	217	20	by	by	IN
cord-297078-pxggjaby	217	21	RNA	RNA	NNP
cord-297078-pxggjaby	217	22	polymerases	polymerase	NNS
cord-297078-pxggjaby	217	23	was	be	VBD
cord-297078-pxggjaby	217	24	realized	realize	VBN
cord-297078-pxggjaby	217	25	,	,	,
cord-297078-pxggjaby	217	26	both	both	CC
cord-297078-pxggjaby	217	27	the	the	DT
cord-297078-pxggjaby	217	28	genome	genome	NN
cord-297078-pxggjaby	217	29	and	and	CC
cord-297078-pxggjaby	217	30	expressed	express	VBN
cord-297078-pxggjaby	217	31	transcripts	transcript	NNS
cord-297078-pxggjaby	217	32	would	would	MD
cord-297078-pxggjaby	217	33	be	be	VB
cord-297078-pxggjaby	217	34	subject	subject	JJ
cord-297078-pxggjaby	217	35	to	to	IN
cord-297078-pxggjaby	217	36	proofreading	proofreading	NN
cord-297078-pxggjaby	217	37	and	and	CC
cord-297078-pxggjaby	217	38	repair	repair	NN
cord-297078-pxggjaby	217	39	,	,	,
cord-297078-pxggjaby	217	40	as	as	IN
cord-297078-pxggjaby	217	41	both	both	DT
cord-297078-pxggjaby	217	42	would	would	MD
cord-297078-pxggjaby	217	43	be	be	VB
cord-297078-pxggjaby	217	44	synthesized	synthesize	VBN
cord-297078-pxggjaby	217	45	by	by	IN
cord-297078-pxggjaby	217	46	RNA	RNA	NNP
cord-297078-pxggjaby	217	47	polymerase	polymerase	NN
cord-297078-pxggjaby	217	48	.	.	.
cord-297078-pxggjaby	218	1	It	-PRON-	PRP
cord-297078-pxggjaby	218	2	is	be	VBZ
cord-297078-pxggjaby	218	3	of	of	IN
cord-297078-pxggjaby	218	4	course	course	NN
cord-297078-pxggjaby	218	5	possible	possible	JJ
cord-297078-pxggjaby	218	6	that	that	IN
cord-297078-pxggjaby	218	7	the	the	DT
cord-297078-pxggjaby	218	8	potential	potential	NN
cord-297078-pxggjaby	218	9	for	for	IN
cord-297078-pxggjaby	218	10	repair	repair	NN
cord-297078-pxggjaby	218	11	inherent	inherent	JJ
cord-297078-pxggjaby	218	12	in	in	IN
cord-297078-pxggjaby	218	13	the	the	DT
cord-297078-pxggjaby	218	14	two	two	CD
cord-297078-pxggjaby	218	15	-	-	HYPH
cord-297078-pxggjaby	218	16	metal	metal	NN
cord-297078-pxggjaby	218	17	mechanism	mechanism	NN
cord-297078-pxggjaby	218	18	of	of	IN
cord-297078-pxggjaby	218	19	catalysis	catalysis	NN
cord-297078-pxggjaby	218	20	was	be	VBD
cord-297078-pxggjaby	218	21	not	not	RB
cord-297078-pxggjaby	218	22	realized	realize	VBN
cord-297078-pxggjaby	218	23	in	in	IN
cord-297078-pxggjaby	218	24	the	the	DT
cord-297078-pxggjaby	218	25	LUCA	LUCA	NNP
cord-297078-pxggjaby	218	26	and	and	CC
cord-297078-pxggjaby	218	27	that	that	IN
cord-297078-pxggjaby	218	28	proofreading	proofreading	NN
cord-297078-pxggjaby	218	29	and	and	CC
cord-297078-pxggjaby	218	30	repair	repair	NN
cord-297078-pxggjaby	218	31	emerged	emerge	VBD
cord-297078-pxggjaby	218	32	later	later	RB
cord-297078-pxggjaby	218	33	,	,	,
cord-297078-pxggjaby	218	34	twice	twice	RB
cord-297078-pxggjaby	218	35	independently	independently	RB
cord-297078-pxggjaby	218	36	(	(	-LRB-
cord-297078-pxggjaby	218	37	perhaps	perhaps	RB
cord-297078-pxggjaby	218	38	in	in	IN
cord-297078-pxggjaby	218	39	conjunction	conjunction	NN
cord-297078-pxggjaby	218	40	with	with	IN
cord-297078-pxggjaby	218	41	the	the	DT
cord-297078-pxggjaby	218	42	appearance	appearance	NN
cord-297078-pxggjaby	218	43	of	of	IN
cord-297078-pxggjaby	218	44	GreA	GreA	NNP
cord-297078-pxggjaby	218	45	/	/	SYM
cord-297078-pxggjaby	218	46	B	B	NNP
cord-297078-pxggjaby	218	47	and	and	CC
cord-297078-pxggjaby	218	48	TFIIS	TFIIS	NNP
cord-297078-pxggjaby	218	49	cleavagestimulatory	cleavagestimulatory	JJ
cord-297078-pxggjaby	218	50	factors	factor	NNS
cord-297078-pxggjaby	218	51	)	)	-RRB-
cord-297078-pxggjaby	218	52	,	,	,
cord-297078-pxggjaby	218	53	as	as	IN
cord-297078-pxggjaby	218	54	a	a	DT
cord-297078-pxggjaby	218	55	form	form	NN
cord-297078-pxggjaby	218	56	of	of	IN
cord-297078-pxggjaby	218	57	mRNA	mRNA	NNP
cord-297078-pxggjaby	218	58	quality	quality	NN
cord-297078-pxggjaby	218	59	control	control	NN
cord-297078-pxggjaby	218	60	.	.	.
cord-297078-pxggjaby	219	1	However	however	RB
cord-297078-pxggjaby	219	2	,	,	,
cord-297078-pxggjaby	219	3	this	this	DT
cord-297078-pxggjaby	219	4	seems	seem	VBZ
cord-297078-pxggjaby	219	5	highly	highly	RB
cord-297078-pxggjaby	219	6	unlikely	unlikely	JJ
cord-297078-pxggjaby	219	7	.	.	.
cord-297078-pxggjaby	220	1	The	the	DT
cord-297078-pxggjaby	220	2	convergent	convergent	JJ
cord-297078-pxggjaby	220	3	evolution	evolution	NN
cord-297078-pxggjaby	220	4	of	of	IN
cord-297078-pxggjaby	220	5	cleavage	cleavage	NN
cord-297078-pxggjaby	220	6	-	-	HYPH
cord-297078-pxggjaby	220	7	stimulatory	stimulatory	JJ
cord-297078-pxggjaby	220	8	factors	factor	NNS
cord-297078-pxggjaby	220	9	suggests	suggest	VBZ
cord-297078-pxggjaby	220	10	that	that	IN
cord-297078-pxggjaby	220	11	the	the	DT
cord-297078-pxggjaby	220	12	intrinsic	intrinsic	JJ
cord-297078-pxggjaby	220	13	proofreading	proofreading	NN
cord-297078-pxggjaby	220	14	and	and	CC
cord-297078-pxggjaby	220	15	repair	repair	NN
cord-297078-pxggjaby	220	16	capability	capability	NN
cord-297078-pxggjaby	220	17	of	of	IN
cord-297078-pxggjaby	220	18	RNA	RNA	NNP
cord-297078-pxggjaby	220	19	polymerases	polymerase	NNS
cord-297078-pxggjaby	220	20	was	be	VBD
cord-297078-pxggjaby	220	21	already	already	RB
cord-297078-pxggjaby	220	22	in	in	IN
cord-297078-pxggjaby	220	23	use	use	NN
cord-297078-pxggjaby	220	24	with	with	IN
cord-297078-pxggjaby	220	25	these	these	DT
cord-297078-pxggjaby	220	26	factors	factor	NNS
cord-297078-pxggjaby	220	27	emerging	emerge	VBG
cord-297078-pxggjaby	220	28	independently	independently	RB
cord-297078-pxggjaby	220	29	as	as	IN
cord-297078-pxggjaby	220	30	evolutionary	evolutionary	JJ
cord-297078-pxggjaby	220	31	refinements	refinement	NNS
cord-297078-pxggjaby	220	32	of	of	IN
cord-297078-pxggjaby	220	33	this	this	DT
cord-297078-pxggjaby	220	34	process	process	NN
cord-297078-pxggjaby	220	35	.	.	.
cord-297078-pxggjaby	221	1	Moreover	moreover	RB
cord-297078-pxggjaby	221	2	,	,	,
cord-297078-pxggjaby	221	3	in	in	IN
cord-297078-pxggjaby	221	4	an	an	DT
cord-297078-pxggjaby	221	5	RNA	RNA	NNP
cord-297078-pxggjaby	221	6	-	-	HYPH
cord-297078-pxggjaby	221	7	based	base	VBN
cord-297078-pxggjaby	221	8	system	system	NN
cord-297078-pxggjaby	221	9	where	where	WRB
cord-297078-pxggjaby	221	10	there	there	EX
cord-297078-pxggjaby	221	11	were	be	VBD
cord-297078-pxggjaby	221	12	strong	strong	JJ
cord-297078-pxggjaby	221	13	limits	limit	NNS
cord-297078-pxggjaby	221	14	on	on	IN
cord-297078-pxggjaby	221	15	coding	code	VBG
cord-297078-pxggjaby	221	16	capacity	capacity	NN
cord-297078-pxggjaby	221	17	,	,	,
cord-297078-pxggjaby	221	18	increases	increase	NNS
cord-297078-pxggjaby	221	19	in	in	IN
cord-297078-pxggjaby	221	20	replication	replication	NN
cord-297078-pxggjaby	221	21	fidelity	fidelity	NN
cord-297078-pxggjaby	221	22	would	would	MD
cord-297078-pxggjaby	221	23	have	have	VB
cord-297078-pxggjaby	221	24	been	be	VBN
cord-297078-pxggjaby	221	25	selectively	selectively	RB
cord-297078-pxggjaby	221	26	advantageous	advantageous	JJ
cord-297078-pxggjaby	221	27	.	.	.
cord-297078-pxggjaby	222	1	We	-PRON-	PRP
cord-297078-pxggjaby	222	2	therefore	therefore	RB
cord-297078-pxggjaby	222	3	think	think	VBP
cord-297078-pxggjaby	222	4	it	-PRON-	PRP
cord-297078-pxggjaby	222	5	highly	highly	RB
cord-297078-pxggjaby	222	6	unlikely	unlikely	JJ
cord-297078-pxggjaby	222	7	that	that	IN
cord-297078-pxggjaby	222	8	this	this	DT
cord-297078-pxggjaby	222	9	intrinsic	intrinsic	JJ
cord-297078-pxggjaby	222	10	capability	capability	NN
cord-297078-pxggjaby	222	11	of	of	IN
cord-297078-pxggjaby	222	12	RNA	RNA	NNP
cord-297078-pxggjaby	222	13	polymerases	polymerase	NNS
cord-297078-pxggjaby	222	14	was	be	VBD
cord-297078-pxggjaby	222	15	not	not	RB
cord-297078-pxggjaby	222	16	co	co	VBN
cord-297078-pxggjaby	222	17	-	-	VBN
cord-297078-pxggjaby	222	18	opted	opt	VBN
cord-297078-pxggjaby	222	19	at	at	IN
cord-297078-pxggjaby	222	20	a	a	DT
cord-297078-pxggjaby	222	21	very	very	RB
cord-297078-pxggjaby	222	22	early	early	JJ
cord-297078-pxggjaby	222	23	stage	stage	NN
cord-297078-pxggjaby	222	24	.	.	.
cord-297078-pxggjaby	223	1	Indirectly	indirectly	RB
cord-297078-pxggjaby	223	2	supporting	support	VBG
cord-297078-pxggjaby	223	3	this	this	DT
cord-297078-pxggjaby	223	4	contention	contention	NN
cord-297078-pxggjaby	223	5	,	,	,
cord-297078-pxggjaby	223	6	this	this	DT
cord-297078-pxggjaby	223	7	capacity	capacity	NN
cord-297078-pxggjaby	223	8	has	have	VBZ
cord-297078-pxggjaby	223	9	been	be	VBN
cord-297078-pxggjaby	223	10	made	make	VBN
cord-297078-pxggjaby	223	11	use	use	NN
cord-297078-pxggjaby	223	12	of	of	IN
cord-297078-pxggjaby	223	13	several	several	JJ
cord-297078-pxggjaby	223	14	times	time	NNS
cord-297078-pxggjaby	223	15	in	in	IN
cord-297078-pxggjaby	223	16	unrelated	unrelated	JJ
cord-297078-pxggjaby	223	17	polymerases	polymerase	NNS
cord-297078-pxggjaby	223	18	,	,	,
cord-297078-pxggjaby	223	19	including	include	VBG
cord-297078-pxggjaby	223	20	both	both	DT
cord-297078-pxggjaby	223	21	single	single	JJ
cord-297078-pxggjaby	223	22	-	-	HYPH
cord-297078-pxggjaby	223	23	and	and	CC
cord-297078-pxggjaby	223	24	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	223	25	RNA	RNA	NNP
cord-297078-pxggjaby	223	26	polymerases	polymerase	NNS
cord-297078-pxggjaby	223	27	(	(	-LRB-
cord-297078-pxggjaby	223	28	Steitz	Steitz	NNP
cord-297078-pxggjaby	223	29	1999	1999	CD
cord-297078-pxggjaby	223	30	;	;	:
cord-297078-pxggjaby	223	31	;	;	:
cord-297078-pxggjaby	223	32	table	table	NN
cord-297078-pxggjaby	223	33	1	1	CD
cord-297078-pxggjaby	223	34	)	)	-RRB-
cord-297078-pxggjaby	223	35	,	,	,
cord-297078-pxggjaby	223	36	as	as	RB
cord-297078-pxggjaby	223	37	well	well	RB
cord-297078-pxggjaby	223	38	as	as	IN
cord-297078-pxggjaby	223	39	in	in	IN
cord-297078-pxggjaby	223	40	DNA	dna	NN
cord-297078-pxggjaby	223	41	polymerases	polymerase	NNS
cord-297078-pxggjaby	223	42	,	,	,
cord-297078-pxggjaby	223	43	including	include	VBG
cord-297078-pxggjaby	223	44	3#-5	3#-5	NNP
cord-297078-pxggjaby	223	45	#	#	NN
cord-297078-pxggjaby	223	46	exonuclease	exonuclease	NN
cord-297078-pxggjaby	223	47	activity	activity	NN
cord-297078-pxggjaby	223	48	of	of	IN
cord-297078-pxggjaby	223	49	the	the	DT
cord-297078-pxggjaby	223	50	Klenow	Klenow	NNP
cord-297078-pxggjaby	223	51	fragment	fragment	NN
cord-297078-pxggjaby	223	52	(	(	-LRB-
cord-297078-pxggjaby	223	53	Steitz	Steitz	NNP
cord-297078-pxggjaby	223	54	1999	1999	CD
cord-297078-pxggjaby	223	55	)	)	-RRB-
cord-297078-pxggjaby	223	56	.	.	.
cord-297078-pxggjaby	224	1	Moreover	moreover	RB
cord-297078-pxggjaby	224	2	,	,	,
cord-297078-pxggjaby	224	3	such	such	PDT
cord-297078-pxggjaby	224	4	a	a	DT
cord-297078-pxggjaby	224	5	two	two	CD
cord-297078-pxggjaby	224	6	-	-	HYPH
cord-297078-pxggjaby	224	7	metal	metal	NN
cord-297078-pxggjaby	224	8	ion	ion	NN
cord-297078-pxggjaby	224	9	mechanism	mechanism	NN
cord-297078-pxggjaby	224	10	has	have	VBZ
cord-297078-pxggjaby	224	11	been	be	VBN
cord-297078-pxggjaby	224	12	proposed	propose	VBN
cord-297078-pxggjaby	224	13	to	to	TO
cord-297078-pxggjaby	224	14	be	be	VB
cord-297078-pxggjaby	224	15	possible	possible	JJ
cord-297078-pxggjaby	224	16	with	with	IN
cord-297078-pxggjaby	224	17	RNA	RNA	NNP
cord-297078-pxggjaby	224	18	alone	alone	RB
cord-297078-pxggjaby	224	19	,	,	,
cord-297078-pxggjaby	224	20	both	both	DT
cord-297078-pxggjaby	224	21	for	for	IN
cord-297078-pxggjaby	224	22	polymerization	polymerization	NN
cord-297078-pxggjaby	224	23	and	and	CC
cord-297078-pxggjaby	224	24	exonuclease	exonuclease	NN
cord-297078-pxggjaby	224	25	reactions	reaction	NNS
cord-297078-pxggjaby	225	1	(	(	-LRB-
cord-297078-pxggjaby	225	2	T.	T.	NNP
cord-297078-pxggjaby	225	3	A.	a.	NN
cord-297078-pxggjaby	225	4	Steitz	Steitz	NNP
cord-297078-pxggjaby	225	5	and	and	CC
cord-297078-pxggjaby	225	6	J.	J.	NNP
cord-297078-pxggjaby	225	7	A.	A.	NNP
cord-297078-pxggjaby	225	8	Steitz	Steitz	NNP
cord-297078-pxggjaby	225	9	1993	1993	CD
cord-297078-pxggjaby	225	10	;	;	:
cord-297078-pxggjaby	226	1	Steitz	Steitz	NNP
cord-297078-pxggjaby	226	2	1998	1998	CD
cord-297078-pxggjaby	226	3	)	)	-RRB-
cord-297078-pxggjaby	226	4	.	.	.
cord-297078-pxggjaby	227	1	Certainly	certainly	RB
cord-297078-pxggjaby	227	2	,	,	,
cord-297078-pxggjaby	227	3	it	-PRON-	PRP
cord-297078-pxggjaby	227	4	seems	seem	VBZ
cord-297078-pxggjaby	227	5	somewhat	somewhat	RB
cord-297078-pxggjaby	227	6	difficult	difficult	JJ
cord-297078-pxggjaby	227	7	to	to	TO
cord-297078-pxggjaby	227	8	contend	contend	VB
cord-297078-pxggjaby	227	9	that	that	IN
cord-297078-pxggjaby	227	10	this	this	DT
cord-297078-pxggjaby	227	11	catalytic	catalytic	JJ
cord-297078-pxggjaby	227	12	capability	capability	NN
cord-297078-pxggjaby	227	13	was	be	VBD
cord-297078-pxggjaby	227	14	utilized	utilize	VBN
cord-297078-pxggjaby	227	15	in	in	IN
cord-297078-pxggjaby	227	16	mRNA	mRNA	NNP
cord-297078-pxggjaby	227	17	quality	quality	NNP
cord-297078-pxggjaby	227	18	control	control	NNP
cord-297078-pxggjaby	227	19	post	post	NNP
cord-297078-pxggjaby	227	20	-	-	NNP
cord-297078-pxggjaby	227	21	LUCA	LUCA	NNP
cord-297078-pxggjaby	227	22	but	but	CC
cord-297078-pxggjaby	227	23	not	not	RB
cord-297078-pxggjaby	227	24	in	in	IN
cord-297078-pxggjaby	227	25	LUCA	LUCA	NNP
cord-297078-pxggjaby	227	26	.	.	.
cord-297078-pxggjaby	228	1	Having	have	VBG
cord-297078-pxggjaby	228	2	said	say	VBD
cord-297078-pxggjaby	228	3	that	that	DT
cord-297078-pxggjaby	228	4	,	,	,
cord-297078-pxggjaby	228	5	if	if	IN
cord-297078-pxggjaby	228	6	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	228	7	RNA	RNA	NNP
cord-297078-pxggjaby	228	8	polymerases	polymerase	NNS
cord-297078-pxggjaby	228	9	had	have	VBD
cord-297078-pxggjaby	228	10	a	a	DT
cord-297078-pxggjaby	228	11	role	role	NN
cord-297078-pxggjaby	228	12	in	in	IN
cord-297078-pxggjaby	228	13	genome	genome	NN
cord-297078-pxggjaby	228	14	maintenance	maintenance	NN
cord-297078-pxggjaby	228	15	at	at	IN
cord-297078-pxggjaby	228	16	some	some	DT
cord-297078-pxggjaby	228	17	early	early	JJ
cord-297078-pxggjaby	228	18	stage	stage	NN
cord-297078-pxggjaby	228	19	in	in	IN
cord-297078-pxggjaby	228	20	evolution	evolution	NN
cord-297078-pxggjaby	228	21	,	,	,
cord-297078-pxggjaby	228	22	they	-PRON-	PRP
cord-297078-pxggjaby	228	23	must	must	MD
cord-297078-pxggjaby	228	24	have	have	VB
cord-297078-pxggjaby	228	25	initially	initially	RB
cord-297078-pxggjaby	228	26	recognized	recognize	VBN
cord-297078-pxggjaby	228	27	RNA	RNA	NNP
cord-297078-pxggjaby	228	28	as	as	IN
cord-297078-pxggjaby	228	29	template	template	NN
cord-297078-pxggjaby	228	30	,	,	,
cord-297078-pxggjaby	228	31	not	not	RB
cord-297078-pxggjaby	228	32	DNA	DNA	NNP
cord-297078-pxggjaby	228	33	,	,	,
cord-297078-pxggjaby	228	34	as	as	IN
cord-297078-pxggjaby	228	35	in	in	IN
cord-297078-pxggjaby	228	36	modern	modern	JJ
cord-297078-pxggjaby	228	37	enzymes	enzyme	NNS
cord-297078-pxggjaby	228	38	.	.	.
cord-297078-pxggjaby	229	1	Two	two	CD
cord-297078-pxggjaby	229	2	lines	line	NNS
cord-297078-pxggjaby	229	3	of	of	IN
cord-297078-pxggjaby	229	4	evidence	evidence	NN
cord-297078-pxggjaby	229	5	demonstrate	demonstrate	VBP
cord-297078-pxggjaby	229	6	this	this	DT
cord-297078-pxggjaby	229	7	to	to	TO
cord-297078-pxggjaby	229	8	be	be	VB
cord-297078-pxggjaby	229	9	feasible	feasible	JJ
cord-297078-pxggjaby	229	10	and	and	CC
cord-297078-pxggjaby	229	11	in	in	IN
cord-297078-pxggjaby	229	12	fact	fact	NN
cord-297078-pxggjaby	229	13	still	still	RB
cord-297078-pxggjaby	229	14	biologically	biologically	RB
cord-297078-pxggjaby	229	15	relevant	relevant	JJ
cord-297078-pxggjaby	229	16	.	.	.
cord-297078-pxggjaby	230	1	Over	over	IN
cord-297078-pxggjaby	230	2	30	30	CD
cord-297078-pxggjaby	230	3	years	year	NNS
cord-297078-pxggjaby	230	4	ago	ago	RB
cord-297078-pxggjaby	230	5	,	,	,
cord-297078-pxggjaby	230	6	Biebricher	Biebricher	NNP
cord-297078-pxggjaby	230	7	and	and	CC
cord-297078-pxggjaby	230	8	Orgel	Orgel	NNP
cord-297078-pxggjaby	230	9	(	(	-LRB-
cord-297078-pxggjaby	230	10	1973	1973	CD
cord-297078-pxggjaby	230	11	)	)	-RRB-
cord-297078-pxggjaby	230	12	published	publish	VBD
cord-297078-pxggjaby	230	13	evidence	evidence	NN
cord-297078-pxggjaby	230	14	that	that	IN
cord-297078-pxggjaby	230	15	DNA	dna	NN
cord-297078-pxggjaby	230	16	-	-	HYPH
cord-297078-pxggjaby	230	17	dependent	dependent	JJ
cord-297078-pxggjaby	230	18	RNA	RNA	NNP
cord-297078-pxggjaby	230	19	polymerase	polymerase	NN
cord-297078-pxggjaby	230	20	from	from	IN
cord-297078-pxggjaby	230	21	E.	E.	NNP
cord-297078-pxggjaby	230	22	coli	coli	NNS
cord-297078-pxggjaby	230	23	was	be	VBD
cord-297078-pxggjaby	230	24	capable	capable	JJ
cord-297078-pxggjaby	230	25	of	of	IN
cord-297078-pxggjaby	230	26	accepting	accept	VBG
cord-297078-pxggjaby	230	27	an	an	DT
cord-297078-pxggjaby	230	28	RNA	RNA	NNP
cord-297078-pxggjaby	230	29	template	template	NN
cord-297078-pxggjaby	230	30	,	,	,
cord-297078-pxggjaby	230	31	and	and	CC
cord-297078-pxggjaby	230	32	more	more	JJR
cord-297078-pxggjaby	230	33	recent	recent	JJ
cord-297078-pxggjaby	230	34	studies	study	NNS
cord-297078-pxggjaby	230	35	confirm	confirm	VBP
cord-297078-pxggjaby	230	36	this	this	DT
cord-297078-pxggjaby	230	37	(	(	-LRB-
cord-297078-pxggjaby	230	38	Wettich	Wettich	NNP
cord-297078-pxggjaby	230	39	and	and	CC
cord-297078-pxggjaby	230	40	Biebricher	Biebricher	NNP
cord-297078-pxggjaby	230	41	2001	2001	CD
cord-297078-pxggjaby	230	42	;	;	:
cord-297078-pxggjaby	230	43	Pelchat	Pelchat	NNP
cord-297078-pxggjaby	230	44	,	,	,
cord-297078-pxggjaby	230	45	Grenier	Grenier	NNP
cord-297078-pxggjaby	230	46	,	,	,
cord-297078-pxggjaby	230	47	and	and	CC
cord-297078-pxggjaby	230	48	Perreault	Perreault	NNP
cord-297078-pxggjaby	230	49	2002	2002	CD
cord-297078-pxggjaby	230	50	)	)	-RRB-
cord-297078-pxggjaby	230	51	.	.	.
cord-297078-pxggjaby	231	1	While	while	IN
cord-297078-pxggjaby	231	2	the	the	DT
cord-297078-pxggjaby	231	3	RNA	RNA	NNP
cord-297078-pxggjaby	231	4	-	-	HYPH
cord-297078-pxggjaby	231	5	replicating	replicate	VBG
cord-297078-pxggjaby	231	6	capacity	capacity	NN
cord-297078-pxggjaby	231	7	of	of	IN
cord-297078-pxggjaby	231	8	E.	E.	NNP
cord-297078-pxggjaby	231	9	coli	coli	NNS
cord-297078-pxggjaby	231	10	RNA	RNA	NNP
cord-297078-pxggjaby	231	11	polymerase	polymerase	NN
cord-297078-pxggjaby	231	12	is	be	VBZ
cord-297078-pxggjaby	231	13	not	not	RB
cord-297078-pxggjaby	231	14	physiological	physiological	JJ
cord-297078-pxggjaby	231	15	,	,	,
cord-297078-pxggjaby	231	16	such	such	PDT
cord-297078-pxggjaby	231	17	an	an	DT
cord-297078-pxggjaby	231	18	example	example	NN
cord-297078-pxggjaby	231	19	is	be	VBZ
cord-297078-pxggjaby	231	20	known	know	VBN
cord-297078-pxggjaby	231	21	.	.	.
cord-297078-pxggjaby	232	1	In	in	IN
cord-297078-pxggjaby	232	2	plants	plant	NNS
cord-297078-pxggjaby	232	3	,	,	,
cord-297078-pxggjaby	232	4	RNA	RNA	NNP
cord-297078-pxggjaby	232	5	polymerase	polymerase	NN
cord-297078-pxggjaby	232	6	II	II	NNP
cord-297078-pxggjaby	232	7	is	be	VBZ
cord-297078-pxggjaby	232	8	co	co	VBN
cord-297078-pxggjaby	232	9	-	-	VBN
cord-297078-pxggjaby	232	10	opted	opt	VBN
cord-297078-pxggjaby	232	11	into	into	IN
cord-297078-pxggjaby	232	12	replication	replication	NN
cord-297078-pxggjaby	232	13	of	of	IN
cord-297078-pxggjaby	232	14	viroids	viroid	NNS
cord-297078-pxggjaby	232	15	(	(	-LRB-
cord-297078-pxggjaby	232	16	Mühlbach	Mühlbach	NNP
cord-297078-pxggjaby	232	17	and	and	CC
cord-297078-pxggjaby	232	18	Sanger	Sanger	NNP
cord-297078-pxggjaby	232	19	1979	1979	CD
cord-297078-pxggjaby	232	20	;	;	:
cord-297078-pxggjaby	232	21	Schindler	Schindler	NNP
cord-297078-pxggjaby	232	22	and	and	CC
cord-297078-pxggjaby	232	23	Mühlbach	Mühlbach	NNP
cord-297078-pxggjaby	232	24	1992	1992	CD
cord-297078-pxggjaby	232	25	;	;	:
cord-297078-pxggjaby	232	26	Fels	Fels	NNP
cord-297078-pxggjaby	232	27	,	,	,
cord-297078-pxggjaby	232	28	Hu	Hu	NNP
cord-297078-pxggjaby	232	29	,	,	,
cord-297078-pxggjaby	232	30	and	and	CC
cord-297078-pxggjaby	232	31	Riesner	Riesner	NNP
cord-297078-pxggjaby	232	32	2001	2001	CD
cord-297078-pxggjaby	232	33	)	)	-RRB-
cord-297078-pxggjaby	232	34	-pathogenic	-pathogenic	WDT
cord-297078-pxggjaby	232	35	autonomously	autonomously	RB
cord-297078-pxggjaby	232	36	replicating	replicate	VBG
cord-297078-pxggjaby	232	37	single	single	JJ
cord-297078-pxggjaby	232	38	-	-	HYPH
cord-297078-pxggjaby	232	39	stranded	strand	VBN
cord-297078-pxggjaby	232	40	circular	circular	JJ
cord-297078-pxggjaby	232	41	RNAs	rna	NNS
cord-297078-pxggjaby	232	42	reaching	reach	VBG
cord-297078-pxggjaby	232	43	approximately	approximately	RB
cord-297078-pxggjaby	232	44	400	400	CD
cord-297078-pxggjaby	232	45	bases	basis	NNS
cord-297078-pxggjaby	232	46	in	in	IN
cord-297078-pxggjaby	232	47	length	length	NN
cord-297078-pxggjaby	233	1	(	(	-LRB-
cord-297078-pxggjaby	233	2	Flores	Flores	NNP
cord-297078-pxggjaby	233	3	et	et	NNP
cord-297078-pxggjaby	233	4	al	al	NNP
cord-297078-pxggjaby	233	5	.	.	.
cord-297078-pxggjaby	233	6	2004	2004	CD
cord-297078-pxggjaby	233	7	)	)	-RRB-
cord-297078-pxggjaby	233	8	.	.	.
cord-297078-pxggjaby	234	1	In	in	IN
cord-297078-pxggjaby	234	2	both	both	DT
cord-297078-pxggjaby	234	3	cases	case	NNS
cord-297078-pxggjaby	234	4	,	,	,
cord-297078-pxggjaby	234	5	it	-PRON-	PRP
cord-297078-pxggjaby	234	6	seems	seem	VBZ
cord-297078-pxggjaby	234	7	that	that	IN
cord-297078-pxggjaby	234	8	there	there	EX
cord-297078-pxggjaby	234	9	is	be	VBZ
cord-297078-pxggjaby	234	10	some	some	DT
cord-297078-pxggjaby	234	11	selectivity	selectivity	NN
cord-297078-pxggjaby	234	12	,	,	,
cord-297078-pxggjaby	234	13	with	with	IN
cord-297078-pxggjaby	234	14	replication	replication	NN
cord-297078-pxggjaby	234	15	initiation	initiation	NN
cord-297078-pxggjaby	234	16	requiring	require	VBG
cord-297078-pxggjaby	234	17	some	some	DT
cord-297078-pxggjaby	234	18	degree	degree	NN
cord-297078-pxggjaby	234	19	of	of	IN
cord-297078-pxggjaby	234	20	specificity	specificity	NN
cord-297078-pxggjaby	234	21	,	,	,
cord-297078-pxggjaby	234	22	which	which	WDT
cord-297078-pxggjaby	234	23	may	may	MD
cord-297078-pxggjaby	234	24	be	be	VB
cord-297078-pxggjaby	234	25	some	some	DT
cord-297078-pxggjaby	234	26	combination	combination	NN
cord-297078-pxggjaby	234	27	of	of	IN
cord-297078-pxggjaby	234	28	sequence	sequence	NN
cord-297078-pxggjaby	234	29	and	and	CC
cord-297078-pxggjaby	234	30	structure	structure	NN
cord-297078-pxggjaby	234	31	(	(	-LRB-
cord-297078-pxggjaby	234	32	Fels	Fels	NNP
cord-297078-pxggjaby	234	33	,	,	,
cord-297078-pxggjaby	234	34	Hu	Hu	NNP
cord-297078-pxggjaby	234	35	,	,	,
cord-297078-pxggjaby	234	36	and	and	CC
cord-297078-pxggjaby	234	37	Riesner	Riesner	NNP
cord-297078-pxggjaby	234	38	2001	2001	CD
cord-297078-pxggjaby	234	39	;	;	:
cord-297078-pxggjaby	234	40	Pelchat	Pelchat	NNP
cord-297078-pxggjaby	234	41	,	,	,
cord-297078-pxggjaby	234	42	Grenier	Grenier	NNP
cord-297078-pxggjaby	234	43	,	,	,
cord-297078-pxggjaby	234	44	and	and	CC
cord-297078-pxggjaby	234	45	Perreault	Perreault	NNP
cord-297078-pxggjaby	234	46	2002	2002	CD
cord-297078-pxggjaby	234	47	;	;	:
cord-297078-pxggjaby	234	48	Pelchat	Pelchat	NNP
cord-297078-pxggjaby	234	49	and	and	CC
cord-297078-pxggjaby	234	50	Perreault	Perreault	NNP
cord-297078-pxggjaby	234	51	2004	2004	CD
cord-297078-pxggjaby	234	52	)	)	-RRB-
cord-297078-pxggjaby	234	53	.	.	.
cord-297078-pxggjaby	235	1	A	a	DT
cord-297078-pxggjaby	235	2	second	second	JJ
cord-297078-pxggjaby	235	3	point	point	NN
cord-297078-pxggjaby	235	4	of	of	IN
cord-297078-pxggjaby	235	5	concern	concern	NN
cord-297078-pxggjaby	235	6	is	be	VBZ
cord-297078-pxggjaby	235	7	the	the	DT
cord-297078-pxggjaby	235	8	fidelity	fidelity	NN
cord-297078-pxggjaby	235	9	of	of	IN
cord-297078-pxggjaby	235	10	modern	modern	JJ
cord-297078-pxggjaby	235	11	RNA	RNA	NNP
cord-297078-pxggjaby	235	12	polymerases	polymerase	NNS
cord-297078-pxggjaby	235	13	.	.	.
cord-297078-pxggjaby	236	1	In	in	IN
cord-297078-pxggjaby	236	2	the	the	DT
cord-297078-pxggjaby	236	3	absence	absence	NN
cord-297078-pxggjaby	236	4	of	of	IN
cord-297078-pxggjaby	236	5	cleavage	cleavage	NN
cord-297078-pxggjaby	236	6	-	-	HYPH
cord-297078-pxggjaby	236	7	stimulatory	stimulatory	JJ
cord-297078-pxggjaby	236	8	factors	factor	NNS
cord-297078-pxggjaby	236	9	,	,	,
cord-297078-pxggjaby	236	10	proofreading	proofreading	NN
cord-297078-pxggjaby	236	11	and	and	CC
cord-297078-pxggjaby	236	12	repair	repair	NN
cord-297078-pxggjaby	236	13	are	be	VBP
cord-297078-pxggjaby	236	14	reduced	reduce	VBN
cord-297078-pxggjaby	236	15	,	,	,
cord-297078-pxggjaby	236	16	and	and	CC
cord-297078-pxggjaby	236	17	one	one	PRP
cord-297078-pxggjaby	236	18	may	may	MD
cord-297078-pxggjaby	236	19	wonder	wonder	VB
cord-297078-pxggjaby	236	20	whether	whether	IN
cord-297078-pxggjaby	236	21	it	-PRON-	PRP
cord-297078-pxggjaby	236	22	is	be	VBZ
cord-297078-pxggjaby	236	23	mechanistically	mechanistically	RB
cord-297078-pxggjaby	236	24	possible	possible	JJ
cord-297078-pxggjaby	236	25	for	for	IN
cord-297078-pxggjaby	236	26	an	an	DT
cord-297078-pxggjaby	236	27	RNA	RNA	NNP
cord-297078-pxggjaby	236	28	polymerase	polymerase	NN
cord-297078-pxggjaby	236	29	to	to	TO
cord-297078-pxggjaby	236	30	operate	operate	VB
cord-297078-pxggjaby	236	31	at	at	IN
cord-297078-pxggjaby	236	32	higher	high	JJR
cord-297078-pxggjaby	236	33	fidelity	fidelity	NN
cord-297078-pxggjaby	236	34	than	than	IN
cord-297078-pxggjaby	236	35	natural	natural	JJ
cord-297078-pxggjaby	236	36	polymerases	polymerase	NNS
cord-297078-pxggjaby	236	37	.	.	.
cord-297078-pxggjaby	237	1	In	in	IN
cord-297078-pxggjaby	237	2	the	the	DT
cord-297078-pxggjaby	237	3	case	case	NN
cord-297078-pxggjaby	237	4	of	of	IN
cord-297078-pxggjaby	237	5	DNA	dna	NN
cord-297078-pxggjaby	237	6	polymerases	polymerase	NNS
cord-297078-pxggjaby	237	7	,	,	,
cord-297078-pxggjaby	237	8	it	-PRON-	PRP
cord-297078-pxggjaby	237	9	is	be	VBZ
cord-297078-pxggjaby	237	10	clear	clear	JJ
cord-297078-pxggjaby	237	11	that	that	IN
cord-297078-pxggjaby	237	12	fidelity	fidelity	NN
cord-297078-pxggjaby	237	13	differs	differ	VBZ
cord-297078-pxggjaby	237	14	considerably	considerably	RB
cord-297078-pxggjaby	237	15	between	between	IN
cord-297078-pxggjaby	237	16	replicative	replicative	JJ
cord-297078-pxggjaby	237	17	and	and	CC
cord-297078-pxggjaby	237	18	repair	repair	NN
cord-297078-pxggjaby	237	19	-	-	HYPH
cord-297078-pxggjaby	237	20	specific	specific	JJ
cord-297078-pxggjaby	237	21	polymerases	polymerase	NNS
cord-297078-pxggjaby	237	22	(	(	-LRB-
cord-297078-pxggjaby	237	23	Beard	Beard	NNP
cord-297078-pxggjaby	237	24	and	and	CC
cord-297078-pxggjaby	237	25	Wilson	Wilson	NNP
cord-297078-pxggjaby	237	26	2003	2003	CD
cord-297078-pxggjaby	237	27	)	)	-RRB-
cord-297078-pxggjaby	237	28	,	,	,
cord-297078-pxggjaby	237	29	and	and	CC
cord-297078-pxggjaby	237	30	DNA	dna	NN
cord-297078-pxggjaby	237	31	polymerase	polymerase	NN
cord-297078-pxggjaby	237	32	mutants	mutant	NNS
cord-297078-pxggjaby	237	33	with	with	IN
cord-297078-pxggjaby	237	34	increased	increase	VBN
cord-297078-pxggjaby	237	35	replication	replication	NN
cord-297078-pxggjaby	237	36	fidelity	fidelity	NN
cord-297078-pxggjaby	237	37	have	have	VBP
cord-297078-pxggjaby	237	38	been	be	VBN
cord-297078-pxggjaby	237	39	selected	select	VBN
cord-297078-pxggjaby	237	40	in	in	IN
cord-297078-pxggjaby	237	41	mutagenesis	mutagenesis	NN
cord-297078-pxggjaby	237	42	screens	screen	NNS
cord-297078-pxggjaby	237	43	(	(	-LRB-
cord-297078-pxggjaby	237	44	Fijalkowska	Fijalkowska	NNP
cord-297078-pxggjaby	237	45	,	,	,
cord-297078-pxggjaby	237	46	Dunn	Dunn	NNP
cord-297078-pxggjaby	237	47	,	,	,
cord-297078-pxggjaby	237	48	and	and	CC
cord-297078-pxggjaby	237	49	Schaaper	Schaaper	NNP
cord-297078-pxggjaby	237	50	1993	1993	CD
cord-297078-pxggjaby	237	51	)	)	-RRB-
cord-297078-pxggjaby	237	52	.	.	.
cord-297078-pxggjaby	238	1	To	to	IN
cord-297078-pxggjaby	238	2	our	-PRON-	PRP$
cord-297078-pxggjaby	238	3	knowledge	knowledge	NN
cord-297078-pxggjaby	238	4	,	,	,
cord-297078-pxggjaby	238	5	this	this	DT
cord-297078-pxggjaby	238	6	has	have	VBZ
cord-297078-pxggjaby	238	7	not	not	RB
cord-297078-pxggjaby	238	8	been	be	VBN
cord-297078-pxggjaby	238	9	done	do	VBN
cord-297078-pxggjaby	238	10	for	for	IN
cord-297078-pxggjaby	238	11	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	238	12	RNA	RNA	NNP
cord-297078-pxggjaby	238	13	polymerases	polymerase	NNS
cord-297078-pxggjaby	238	14	,	,	,
cord-297078-pxggjaby	238	15	but	but	CC
cord-297078-pxggjaby	238	16	an	an	DT
cord-297078-pxggjaby	238	17	example	example	NN
cord-297078-pxggjaby	238	18	does	do	VBZ
cord-297078-pxggjaby	238	19	exist	exist	VB
cord-297078-pxggjaby	238	20	for	for	IN
cord-297078-pxggjaby	238	21	the	the	DT
cord-297078-pxggjaby	238	22	single	single	JJ
cord-297078-pxggjaby	238	23	-	-	HYPH
cord-297078-pxggjaby	238	24	subunit	subunit	NN
cord-297078-pxggjaby	238	25	RNAdependent	RNAdependent	NNP
cord-297078-pxggjaby	238	26	RNA	RNA	NNP
cord-297078-pxggjaby	238	27	polymerase	polymerase	NN
cord-297078-pxggjaby	238	28	from	from	IN
cord-297078-pxggjaby	238	29	poliovirus	poliovirus	NN
cord-297078-pxggjaby	238	30	.	.	.
cord-297078-pxggjaby	239	1	This	this	DT
cord-297078-pxggjaby	239	2	mutant	mutant	NN
cord-297078-pxggjaby	239	3	was	be	VBD
cord-297078-pxggjaby	239	4	selected	select	VBN
cord-297078-pxggjaby	239	5	for	for	IN
cord-297078-pxggjaby	239	6	resistance	resistance	NN
cord-297078-pxggjaby	239	7	to	to	IN
cord-297078-pxggjaby	239	8	ribavirin	ribavirin	NN
cord-297078-pxggjaby	239	9	,	,	,
cord-297078-pxggjaby	239	10	which	which	WDT
cord-297078-pxggjaby	239	11	acts	act	VBZ
cord-297078-pxggjaby	239	12	as	as	IN
cord-297078-pxggjaby	239	13	a	a	DT
cord-297078-pxggjaby	239	14	mutagen	mutagen	NN
cord-297078-pxggjaby	239	15	,	,	,
cord-297078-pxggjaby	239	16	increasing	increase	VBG
cord-297078-pxggjaby	239	17	the	the	DT
cord-297078-pxggjaby	239	18	rate	rate	NN
cord-297078-pxggjaby	239	19	of	of	IN
cord-297078-pxggjaby	239	20	mutation	mutation	NN
cord-297078-pxggjaby	239	21	.	.	.
cord-297078-pxggjaby	240	1	The	the	DT
cord-297078-pxggjaby	240	2	mutant	mutant	JJ
cord-297078-pxggjaby	240	3	high	high	JJ
cord-297078-pxggjaby	240	4	-	-	HYPH
cord-297078-pxggjaby	240	5	fidelity	fidelity	NN
cord-297078-pxggjaby	240	6	polymerase	polymerase	NN
cord-297078-pxggjaby	240	7	emerged	emerge	VBD
cord-297078-pxggjaby	240	8	via	via	IN
cord-297078-pxggjaby	240	9	a	a	DT
cord-297078-pxggjaby	240	10	single	single	JJ
cord-297078-pxggjaby	240	11	-	-	HYPH
cord-297078-pxggjaby	240	12	point	point	NN
cord-297078-pxggjaby	240	13	mutation	mutation	NN
cord-297078-pxggjaby	240	14	and	and	CC
cord-297078-pxggjaby	240	15	exhibited	exhibit	VBD
cord-297078-pxggjaby	240	16	an	an	DT
cord-297078-pxggjaby	240	17	elevated	elevated	JJ
cord-297078-pxggjaby	240	18	fidelity	fidelity	NN
cord-297078-pxggjaby	240	19	in	in	IN
cord-297078-pxggjaby	240	20	the	the	DT
cord-297078-pxggjaby	240	21	absence	absence	NN
cord-297078-pxggjaby	240	22	of	of	IN
cord-297078-pxggjaby	240	23	the	the	DT
cord-297078-pxggjaby	240	24	drug	drug	NN
cord-297078-pxggjaby	240	25	(	(	-LRB-
cord-297078-pxggjaby	240	26	Pfeiffer	Pfeiffer	NNP
cord-297078-pxggjaby	240	27	and	and	CC
cord-297078-pxggjaby	240	28	Kirkegaard	Kirkegaard	NNP
cord-297078-pxggjaby	240	29	2003	2003	CD
cord-297078-pxggjaby	240	30	)	)	-RRB-
cord-297078-pxggjaby	240	31	.	.	.
cord-297078-pxggjaby	241	1	This	this	DT
cord-297078-pxggjaby	241	2	is	be	VBZ
cord-297078-pxggjaby	241	3	consistent	consistent	JJ
cord-297078-pxggjaby	241	4	with	with	IN
cord-297078-pxggjaby	241	5	different	different	JJ
cord-297078-pxggjaby	241	6	fidelities	fidelity	NNS
cord-297078-pxggjaby	241	7	observed	observe	VBN
cord-297078-pxggjaby	241	8	for	for	IN
cord-297078-pxggjaby	241	9	RNA	RNA	NNP
cord-297078-pxggjaby	241	10	polymerases	polymerase	NNS
cord-297078-pxggjaby	241	11	from	from	IN
cord-297078-pxggjaby	241	12	different	different	JJ
cord-297078-pxggjaby	241	13	viruses	virus	NNS
cord-297078-pxggjaby	241	14	(	(	-LRB-
cord-297078-pxggjaby	241	15	see	see	VB
cord-297078-pxggjaby	241	16	Pugachev	Pugachev	NNP
cord-297078-pxggjaby	241	17	et	et	NNP
cord-297078-pxggjaby	241	18	al	al	NNP
cord-297078-pxggjaby	241	19	.	.	.
cord-297078-pxggjaby	242	1	[	[	-LRB-
cord-297078-pxggjaby	242	2	2004	2004	CD
cord-297078-pxggjaby	242	3	]	]	-RRB-
cord-297078-pxggjaby	242	4	for	for	IN
cord-297078-pxggjaby	242	5	a	a	DT
cord-297078-pxggjaby	242	6	naturally	naturally	RB
cord-297078-pxggjaby	242	7	occurring	occur	VBG
cord-297078-pxggjaby	242	8	high	high	JJ
cord-297078-pxggjaby	242	9	-	-	HYPH
cord-297078-pxggjaby	242	10	fidelity	fidelity	NN
cord-297078-pxggjaby	242	11	example	example	NN
cord-297078-pxggjaby	242	12	)	)	-RRB-
cord-297078-pxggjaby	242	13	.	.	.
cord-297078-pxggjaby	243	1	It	-PRON-	PRP
cord-297078-pxggjaby	243	2	thus	thus	RB
cord-297078-pxggjaby	243	3	seems	seem	VBZ
cord-297078-pxggjaby	243	4	reasonable	reasonable	JJ
cord-297078-pxggjaby	243	5	to	to	TO
cord-297078-pxggjaby	243	6	suggest	suggest	VB
cord-297078-pxggjaby	243	7	that	that	IN
cord-297078-pxggjaby	243	8	the	the	DT
cord-297078-pxggjaby	243	9	current	current	JJ
cord-297078-pxggjaby	243	10	fidelity	fidelity	NN
cord-297078-pxggjaby	243	11	of	of	IN
cord-297078-pxggjaby	243	12	RNA	RNA	NNP
cord-297078-pxggjaby	243	13	polymerases	polymerase	NNS
cord-297078-pxggjaby	243	14	is	be	VBZ
cord-297078-pxggjaby	243	15	a	a	DT
cord-297078-pxggjaby	243	16	result	result	NN
cord-297078-pxggjaby	243	17	of	of	IN
cord-297078-pxggjaby	243	18	selection	selection	NN
cord-297078-pxggjaby	243	19	,	,	,
cord-297078-pxggjaby	243	20	resulting	result	VBG
cord-297078-pxggjaby	243	21	in	in	IN
cord-297078-pxggjaby	243	22	a	a	DT
cord-297078-pxggjaby	243	23	compromise	compromise	NN
cord-297078-pxggjaby	243	24	between	between	IN
cord-297078-pxggjaby	243	25	processivity	processivity	NN
cord-297078-pxggjaby	243	26	and	and	CC
cord-297078-pxggjaby	243	27	proofreading	proofreading	NN
cord-297078-pxggjaby	243	28	,	,	,
cord-297078-pxggjaby	243	29	and	and	CC
cord-297078-pxggjaby	243	30	that	that	IN
cord-297078-pxggjaby	243	31	higher	high	JJR
cord-297078-pxggjaby	243	32	fidelity	fidelity	NN
cord-297078-pxggjaby	243	33	RNA	RNA	NNP
cord-297078-pxggjaby	243	34	replication	replication	NN
cord-297078-pxggjaby	243	35	in	in	IN
cord-297078-pxggjaby	243	36	LUCA	LUCA	NNP
cord-297078-pxggjaby	243	37	could	could	MD
cord-297078-pxggjaby	243	38	have	have	VB
cord-297078-pxggjaby	243	39	been	be	VBN
cord-297078-pxggjaby	243	40	possible	possible	JJ
cord-297078-pxggjaby	243	41	.	.	.
cord-297078-pxggjaby	244	1	Although	although	IN
cord-297078-pxggjaby	244	2	to	to	IN
cord-297078-pxggjaby	244	3	our	-PRON-	PRP$
cord-297078-pxggjaby	244	4	knowledge	knowledge	NN
cord-297078-pxggjaby	244	5	no	no	DT
cord-297078-pxggjaby	244	6	one	one	NN
cord-297078-pxggjaby	244	7	has	have	VBZ
cord-297078-pxggjaby	244	8	examined	examine	VBN
cord-297078-pxggjaby	244	9	the	the	DT
cord-297078-pxggjaby	244	10	proofreading	proofreading	NN
cord-297078-pxggjaby	244	11	capability	capability	NN
cord-297078-pxggjaby	244	12	of	of	IN
cord-297078-pxggjaby	244	13	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	244	14	DNA	dna	NN
cord-297078-pxggjaby	244	15	-	-	HYPH
cord-297078-pxggjaby	244	16	dependent	dependent	JJ
cord-297078-pxggjaby	244	17	RNA	RNA	NNP
cord-297078-pxggjaby	244	18	polymerases	polymerase	NNS
cord-297078-pxggjaby	244	19	working	work	VBG
cord-297078-pxggjaby	244	20	with	with	IN
cord-297078-pxggjaby	244	21	an	an	DT
cord-297078-pxggjaby	244	22	RNA	RNA	NNP
cord-297078-pxggjaby	244	23	template	template	NN
cord-297078-pxggjaby	244	24	,	,	,
cord-297078-pxggjaby	244	25	the	the	DT
cord-297078-pxggjaby	244	26	above	above	JJ
cord-297078-pxggjaby	244	27	data	datum	NNS
cord-297078-pxggjaby	244	28	demonstrate	demonstrate	VBP
cord-297078-pxggjaby	244	29	the	the	DT
cord-297078-pxggjaby	244	30	biochemical	biochemical	JJ
cord-297078-pxggjaby	244	31	feasibility	feasibility	NN
cord-297078-pxggjaby	244	32	of	of	IN
cord-297078-pxggjaby	244	33	a	a	DT
cord-297078-pxggjaby	244	34	scenario	scenario	NN
cord-297078-pxggjaby	244	35	where	where	WRB
cord-297078-pxggjaby	244	36	LUCA	LUCA	NNP
cord-297078-pxggjaby	244	37	possessed	possess	VBD
cord-297078-pxggjaby	244	38	an	an	DT
cord-297078-pxggjaby	244	39	RNA	RNA	NNP
cord-297078-pxggjaby	244	40	genome	genome	NN
cord-297078-pxggjaby	244	41	that	that	WDT
cord-297078-pxggjaby	244	42	was	be	VBD
cord-297078-pxggjaby	244	43	both	both	DT
cord-297078-pxggjaby	244	44	replicated	replicate	VBN
cord-297078-pxggjaby	244	45	and	and	CC
cord-297078-pxggjaby	244	46	subject	subject	JJ
cord-297078-pxggjaby	244	47	to	to	IN
cord-297078-pxggjaby	244	48	proofreading	proofreading	NN
cord-297078-pxggjaby	244	49	and	and	CC
cord-297078-pxggjaby	244	50	repair	repair	VB
cord-297078-pxggjaby	244	51	by	by	IN
cord-297078-pxggjaby	244	52	a	a	DT
cord-297078-pxggjaby	244	53	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	244	54	RNA	rna	NN
cord-297078-pxggjaby	244	55	polymerase	polymerase	NN
cord-297078-pxggjaby	244	56	.	.	.
cord-297078-pxggjaby	245	1	A	a	DT
cord-297078-pxggjaby	245	2	close	close	JJ
cord-297078-pxggjaby	245	3	examination	examination	NN
cord-297078-pxggjaby	245	4	of	of	IN
cord-297078-pxggjaby	245	5	the	the	DT
cord-297078-pxggjaby	245	6	available	available	JJ
cord-297078-pxggjaby	245	7	literature	literature	NN
cord-297078-pxggjaby	245	8	on	on	IN
cord-297078-pxggjaby	245	9	the	the	DT
cord-297078-pxggjaby	245	10	structure	structure	NN
cord-297078-pxggjaby	245	11	and	and	CC
cord-297078-pxggjaby	245	12	function	function	NN
cord-297078-pxggjaby	245	13	of	of	IN
cord-297078-pxggjaby	245	14	DNA	dna	NN
cord-297078-pxggjaby	245	15	-	-	HYPH
cord-297078-pxggjaby	245	16	dependent	dependent	JJ
cord-297078-pxggjaby	245	17	RNA	RNA	NNP
cord-297078-pxggjaby	245	18	polymerases	polymerase	NNS
cord-297078-pxggjaby	245	19	allows	allow	VBZ
cord-297078-pxggjaby	245	20	us	-PRON-	PRP
cord-297078-pxggjaby	245	21	to	to	TO
cord-297078-pxggjaby	245	22	make	make	VB
cord-297078-pxggjaby	245	23	several	several	JJ
cord-297078-pxggjaby	245	24	statements	statement	NNS
cord-297078-pxggjaby	245	25	of	of	IN
cord-297078-pxggjaby	245	26	relevance	relevance	NN
cord-297078-pxggjaby	245	27	to	to	IN
cord-297078-pxggjaby	245	28	the	the	DT
cord-297078-pxggjaby	245	29	nature	nature	NN
cord-297078-pxggjaby	245	30	of	of	IN
cord-297078-pxggjaby	245	31	LUCA	LUCA	NNP
cord-297078-pxggjaby	245	32	.	.	.
cord-297078-pxggjaby	246	1	First	first	RB
cord-297078-pxggjaby	246	2	,	,	,
cord-297078-pxggjaby	246	3	several	several	JJ
cord-297078-pxggjaby	246	4	compelling	compelling	JJ
cord-297078-pxggjaby	246	5	arguments	argument	NNS
cord-297078-pxggjaby	246	6	can	can	MD
cord-297078-pxggjaby	246	7	be	be	VB
cord-297078-pxggjaby	246	8	made	make	VBN
cord-297078-pxggjaby	246	9	that	that	DT
cord-297078-pxggjaby	246	10	place	place	NN
cord-297078-pxggjaby	246	11	RNA	RNA	NNP
cord-297078-pxggjaby	246	12	repair	repair	NN
cord-297078-pxggjaby	246	13	as	as	IN
cord-297078-pxggjaby	246	14	a	a	DT
cord-297078-pxggjaby	246	15	feature	feature	NN
cord-297078-pxggjaby	246	16	of	of	IN
cord-297078-pxggjaby	246	17	the	the	DT
cord-297078-pxggjaby	246	18	LUCA	LUCA	NNP
cord-297078-pxggjaby	246	19	.	.	.
cord-297078-pxggjaby	247	1	Intrinsic	intrinsic	JJ
cord-297078-pxggjaby	247	2	proofreading	proofreading	NN
cord-297078-pxggjaby	247	3	appears	appear	VBZ
cord-297078-pxggjaby	247	4	to	to	TO
cord-297078-pxggjaby	247	5	be	be	VB
cord-297078-pxggjaby	247	6	a	a	DT
cord-297078-pxggjaby	247	7	feature	feature	NN
cord-297078-pxggjaby	247	8	common	common	JJ
cord-297078-pxggjaby	247	9	to	to	IN
cord-297078-pxggjaby	247	10	all	all	DT
cord-297078-pxggjaby	247	11	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	247	12	RNA	RNA	NNP
cord-297078-pxggjaby	247	13	polymerases	polymerase	NNS
cord-297078-pxggjaby	247	14	(	(	-LRB-
cord-297078-pxggjaby	247	15	table	table	NN
cord-297078-pxggjaby	247	16	1	1	CD
cord-297078-pxggjaby	247	17	)	)	-RRB-
cord-297078-pxggjaby	247	18	,	,	,
cord-297078-pxggjaby	247	19	and	and	CC
cord-297078-pxggjaby	247	20	available	available	JJ
cord-297078-pxggjaby	247	21	structures	structure	NNS
cord-297078-pxggjaby	247	22	show	show	VBP
cord-297078-pxggjaby	247	23	that	that	IN
cord-297078-pxggjaby	247	24	a	a	DT
cord-297078-pxggjaby	247	25	common	common	JJ
cord-297078-pxggjaby	247	26	two	two	CD
cord-297078-pxggjaby	247	27	-	-	HYPH
cord-297078-pxggjaby	247	28	metal	metal	NN
cord-297078-pxggjaby	247	29	ion	ion	NN
cord-297078-pxggjaby	247	30	mechanism	mechanism	NN
cord-297078-pxggjaby	247	31	lies	lie	VBZ
cord-297078-pxggjaby	247	32	at	at	IN
cord-297078-pxggjaby	247	33	the	the	DT
cord-297078-pxggjaby	247	34	heart	heart	NN
cord-297078-pxggjaby	247	35	of	of	IN
cord-297078-pxggjaby	247	36	both	both	DT
cord-297078-pxggjaby	247	37	elongation	elongation	NN
cord-297078-pxggjaby	247	38	and	and	CC
cord-297078-pxggjaby	247	39	editing	editing	NN
cord-297078-pxggjaby	247	40	activities	activity	NNS
cord-297078-pxggjaby	247	41	.	.	.
cord-297078-pxggjaby	248	1	A	a	DT
cord-297078-pxggjaby	248	2	common	common	JJ
cord-297078-pxggjaby	248	3	evolutionary	evolutionary	JJ
cord-297078-pxggjaby	248	4	origin	origin	NN
cord-297078-pxggjaby	248	5	for	for	IN
cord-297078-pxggjaby	248	6	this	this	DT
cord-297078-pxggjaby	248	7	family	family	NN
cord-297078-pxggjaby	248	8	of	of	IN
cord-297078-pxggjaby	248	9	RNA	RNA	NNP
cord-297078-pxggjaby	248	10	polymerases	polymerase	NNS
cord-297078-pxggjaby	248	11	is	be	VBZ
cord-297078-pxggjaby	248	12	evident	evident	JJ
cord-297078-pxggjaby	248	13	from	from	IN
cord-297078-pxggjaby	248	14	both	both	DT
cord-297078-pxggjaby	248	15	sequence	sequence	NN
cord-297078-pxggjaby	248	16	and	and	CC
cord-297078-pxggjaby	248	17	structural	structural	JJ
cord-297078-pxggjaby	248	18	data	datum	NNS
cord-297078-pxggjaby	248	19	(	(	-LRB-
cord-297078-pxggjaby	248	20	Cramer	Cramer	NNP
cord-297078-pxggjaby	248	21	2002a	2002a	CD
cord-297078-pxggjaby	248	22	;	;	:
cord-297078-pxggjaby	248	23	Harris	Harris	NNP
cord-297078-pxggjaby	248	24	et	et	NNP
cord-297078-pxggjaby	248	25	al	al	NNP
cord-297078-pxggjaby	248	26	.	.	NNP
cord-297078-pxggjaby	248	27	2003	2003	CD
cord-297078-pxggjaby	248	28	;	;	:
cord-297078-pxggjaby	248	29	Mirkin	Mirkin	NNP
cord-297078-pxggjaby	248	30	et	et	NNP
cord-297078-pxggjaby	248	31	al	al	NNP
cord-297078-pxggjaby	248	32	.	.	NNP
cord-297078-pxggjaby	248	33	2003	2003	CD
cord-297078-pxggjaby	248	34	)	)	-RRB-
cord-297078-pxggjaby	248	35	,	,	,
cord-297078-pxggjaby	248	36	making	make	VBG
cord-297078-pxggjaby	248	37	it	-PRON-	PRP
cord-297078-pxggjaby	248	38	relatively	relatively	RB
cord-297078-pxggjaby	248	39	straightforward	straightforward	JJ
cord-297078-pxggjaby	248	40	to	to	TO
cord-297078-pxggjaby	248	41	argue	argue	VB
cord-297078-pxggjaby	248	42	that	that	IN
cord-297078-pxggjaby	248	43	a	a	DT
cord-297078-pxggjaby	248	44	polymerase	polymerase	NN
cord-297078-pxggjaby	248	45	resembling	resemble	VBG
cord-297078-pxggjaby	248	46	the	the	DT
cord-297078-pxggjaby	248	47	modern	modern	JJ
cord-297078-pxggjaby	248	48	conserved	conserved	JJ
cord-297078-pxggjaby	248	49	core	core	NN
cord-297078-pxggjaby	248	50	was	be	VBD
cord-297078-pxggjaby	248	51	present	present	JJ
cord-297078-pxggjaby	248	52	in	in	IN
cord-297078-pxggjaby	248	53	LUCA	LUCA	NNP
cord-297078-pxggjaby	248	54	and	and	CC
cord-297078-pxggjaby	248	55	has	have	VBZ
cord-297078-pxggjaby	248	56	not	not	RB
cord-297078-pxggjaby	248	57	been	be	VBN
cord-297078-pxggjaby	248	58	subject	subject	JJ
cord-297078-pxggjaby	248	59	to	to	IN
cord-297078-pxggjaby	248	60	extensive	extensive	JJ
cord-297078-pxggjaby	248	61	horizontal	horizontal	JJ
cord-297078-pxggjaby	248	62	transfer	transfer	NN
cord-297078-pxggjaby	248	63	(	(	-LRB-
cord-297078-pxggjaby	248	64	Tourasse	Tourasse	NNP
cord-297078-pxggjaby	248	65	and	and	CC
cord-297078-pxggjaby	248	66	Gouy	Gouy	NNP
cord-297078-pxggjaby	248	67	1999	1999	CD
cord-297078-pxggjaby	248	68	;	;	:
cord-297078-pxggjaby	249	1	Harris	Harris	NNP
cord-297078-pxggjaby	249	2	et	et	NNP
cord-297078-pxggjaby	249	3	al	al	NNP
cord-297078-pxggjaby	249	4	.	.	NNP
cord-297078-pxggjaby	249	5	2003	2003	CD
cord-297078-pxggjaby	249	6	)	)	-RRB-
cord-297078-pxggjaby	249	7	.	.	.
cord-297078-pxggjaby	250	1	Furthermore	furthermore	RB
cord-297078-pxggjaby	250	2	,	,	,
cord-297078-pxggjaby	250	3	the	the	DT
cord-297078-pxggjaby	250	4	available	available	JJ
cord-297078-pxggjaby	250	5	biochemical	biochemical	JJ
cord-297078-pxggjaby	250	6	and	and	CC
cord-297078-pxggjaby	250	7	structural	structural	JJ
cord-297078-pxggjaby	250	8	data	datum	NNS
cord-297078-pxggjaby	250	9	suggest	suggest	VBP
cord-297078-pxggjaby	250	10	that	that	IN
cord-297078-pxggjaby	250	11	both	both	DT
cord-297078-pxggjaby	250	12	proofreading	proofreading	NN
cord-297078-pxggjaby	250	13	and	and	CC
cord-297078-pxggjaby	250	14	repair	repair	NN
cord-297078-pxggjaby	250	15	of	of	IN
cord-297078-pxggjaby	250	16	genomic	genomic	NN
cord-297078-pxggjaby	250	17	(	(	-LRB-
cord-297078-pxggjaby	250	18	and	and	CC
cord-297078-pxggjaby	250	19	transcribed	transcribe	VBN
cord-297078-pxggjaby	250	20	)	)	-RRB-
cord-297078-pxggjaby	251	1	RNA	RNA	NNP
cord-297078-pxggjaby	251	2	by	by	IN
cord-297078-pxggjaby	251	3	RNA	RNA	NNP
cord-297078-pxggjaby	251	4	polymerases	polymerase	NNS
cord-297078-pxggjaby	251	5	would	would	MD
cord-297078-pxggjaby	251	6	have	have	VB
cord-297078-pxggjaby	251	7	preceded	precede	VBN
cord-297078-pxggjaby	251	8	the	the	DT
cord-297078-pxggjaby	251	9	origins	origin	NNS
cord-297078-pxggjaby	251	10	of	of	IN
cord-297078-pxggjaby	251	11	DNA	dna	NN
cord-297078-pxggjaby	251	12	.	.	.
cord-297078-pxggjaby	252	1	The	the	DT
cord-297078-pxggjaby	252	2	main	main	JJ
cord-297078-pxggjaby	252	3	conclusion	conclusion	NN
cord-297078-pxggjaby	252	4	we	-PRON-	PRP
cord-297078-pxggjaby	252	5	draw	draw	VBP
cord-297078-pxggjaby	252	6	is	be	VBZ
cord-297078-pxggjaby	252	7	that	that	IN
cord-297078-pxggjaby	252	8	an	an	DT
cord-297078-pxggjaby	252	9	early	early	JJ
cord-297078-pxggjaby	252	10	origin	origin	NN
cord-297078-pxggjaby	252	11	for	for	IN
cord-297078-pxggjaby	252	12	RNA	RNA	NNP
cord-297078-pxggjaby	252	13	repair	repair	NN
cord-297078-pxggjaby	252	14	is	be	VBZ
cord-297078-pxggjaby	252	15	likely	likely	JJ
cord-297078-pxggjaby	252	16	.	.	.
cord-297078-pxggjaby	253	1	RNA	RNA	NNP
cord-297078-pxggjaby	253	2	polymerase	polymerase	NN
cord-297078-pxggjaby	253	3	-	-	HYPH
cord-297078-pxggjaby	253	4	mediated	mediate	VBN
cord-297078-pxggjaby	253	5	proofreading	proofreading	NN
cord-297078-pxggjaby	253	6	and	and	CC
cord-297078-pxggjaby	253	7	repair	repair	NN
cord-297078-pxggjaby	253	8	resolves	resolve	VBZ
cord-297078-pxggjaby	253	9	the	the	DT
cord-297078-pxggjaby	253	10	problem	problem	NN
cord-297078-pxggjaby	253	11	of	of	IN
cord-297078-pxggjaby	253	12	how	how	WRB
cord-297078-pxggjaby	253	13	an	an	DT
cord-297078-pxggjaby	253	14	RNA	RNA	NNP
cord-297078-pxggjaby	253	15	genome	genome	NN
cord-297078-pxggjaby	253	16	could	could	MD
cord-297078-pxggjaby	253	17	have	have	VB
cord-297078-pxggjaby	253	18	maintained	maintain	VBN
cord-297078-pxggjaby	253	19	sufficient	sufficient	JJ
cord-297078-pxggjaby	253	20	genetic	genetic	JJ
cord-297078-pxggjaby	253	21	information	information	NN
cord-297078-pxggjaby	253	22	for	for	IN
cord-297078-pxggjaby	253	23	complex	complex	JJ
cord-297078-pxggjaby	253	24	processes	process	NNS
cord-297078-pxggjaby	253	25	to	to	TO
cord-297078-pxggjaby	253	26	emerge	emerge	VB
cord-297078-pxggjaby	253	27	(	(	-LRB-
cord-297078-pxggjaby	253	28	Poole	Poole	NNP
cord-297078-pxggjaby	253	29	,	,	,
cord-297078-pxggjaby	253	30	Penny	Penny	NNP
cord-297078-pxggjaby	253	31	,	,	,
cord-297078-pxggjaby	253	32	and	and	CC
cord-297078-pxggjaby	253	33	Sjöberg	Sjöberg	NNP
cord-297078-pxggjaby	253	34	2000	2000	CD
cord-297078-pxggjaby	253	35	)	)	-RRB-
cord-297078-pxggjaby	253	36	.	.	.
cord-297078-pxggjaby	254	1	Moreover	moreover	RB
cord-297078-pxggjaby	254	2	,	,	,
cord-297078-pxggjaby	254	3	in	in	IN
cord-297078-pxggjaby	254	4	providing	provide	VBG
cord-297078-pxggjaby	254	5	a	a	DT
cord-297078-pxggjaby	254	6	possible	possible	JJ
cord-297078-pxggjaby	254	7	solution	solution	NN
cord-297078-pxggjaby	254	8	to	to	IN
cord-297078-pxggjaby	254	9	the	the	DT
cord-297078-pxggjaby	254	10	RNA	RNA	NNP
cord-297078-pxggjaby	254	11	-	-	HYPH
cord-297078-pxggjaby	254	12	coding	code	VBG
cord-297078-pxggjaby	254	13	capacity	capacity	NN
cord-297078-pxggjaby	254	14	conundrum	conundrum	NN
cord-297078-pxggjaby	254	15	,	,	,
cord-297078-pxggjaby	254	16	it	-PRON-	PRP
cord-297078-pxggjaby	254	17	lends	lend	VBZ
cord-297078-pxggjaby	254	18	credibility	credibility	NN
cord-297078-pxggjaby	254	19	to	to	IN
cord-297078-pxggjaby	254	20	a	a	DT
cord-297078-pxggjaby	254	21	late	late	JJ
cord-297078-pxggjaby	254	22	-	-	HYPH
cord-297078-pxggjaby	254	23	independent	independent	JJ
cord-297078-pxggjaby	254	24	origin	origin	NN
cord-297078-pxggjaby	254	25	for	for	IN
cord-297078-pxggjaby	254	26	the	the	DT
cord-297078-pxggjaby	254	27	two	two	CD
cord-297078-pxggjaby	254	28	forms	form	NNS
cord-297078-pxggjaby	254	29	of	of	IN
cord-297078-pxggjaby	254	30	DNA	dna	NN
cord-297078-pxggjaby	254	31	replication	replication	NN
cord-297078-pxggjaby	254	32	apparatus	apparatus	NN
cord-297078-pxggjaby	254	33	,	,	,
cord-297078-pxggjaby	254	34	putting	put	VBG
cord-297078-pxggjaby	254	35	the	the	DT
cord-297078-pxggjaby	254	36	RNA	RNA	NNP
cord-297078-pxggjaby	254	37	-	-	HYPH
cord-297078-pxggjaby	254	38	based	base	VBN
cord-297078-pxggjaby	254	39	LUCA	LUCA	NNP
cord-297078-pxggjaby	254	40	scenario	scenario	NN
cord-297078-pxggjaby	254	41	on	on	IN
cord-297078-pxggjaby	254	42	an	an	DT
cord-297078-pxggjaby	254	43	equal	equal	JJ
cord-297078-pxggjaby	254	44	footing	footing	NN
cord-297078-pxggjaby	254	45	with	with	IN
cord-297078-pxggjaby	254	46	a	a	DT
cord-297078-pxggjaby	254	47	DNA	dna	NN
cord-297078-pxggjaby	254	48	-	-	HYPH
cord-297078-pxggjaby	254	49	based	base	VBN
cord-297078-pxggjaby	254	50	LUCA	LUCA	NNP
cord-297078-pxggjaby	254	51	.	.	.
cord-297078-pxggjaby	255	1	We	-PRON-	PRP
cord-297078-pxggjaby	255	2	believe	believe	VBP
cord-297078-pxggjaby	255	3	that	that	IN
cord-297078-pxggjaby	255	4	the	the	DT
cord-297078-pxggjaby	255	5	simplest	simple	JJS
cord-297078-pxggjaby	255	6	explanation	explanation	NN
cord-297078-pxggjaby	255	7	of	of	IN
cord-297078-pxggjaby	255	8	the	the	DT
cord-297078-pxggjaby	255	9	data	data	NN
cord-297078-pxggjaby	255	10	comes	come	VBZ
cord-297078-pxggjaby	255	11	by	by	IN
cord-297078-pxggjaby	255	12	invoking	invoke	VBG
cord-297078-pxggjaby	255	13	an	an	DT
cord-297078-pxggjaby	255	14	RNA	RNA	NNP
cord-297078-pxggjaby	255	15	-	-	HYPH
cord-297078-pxggjaby	255	16	based	base	VBN
cord-297078-pxggjaby	255	17	LUCA	LUCA	NNP
cord-297078-pxggjaby	255	18	.	.	.
cord-297078-pxggjaby	256	1	In	in	IN
cord-297078-pxggjaby	256	2	this	this	DT
cord-297078-pxggjaby	256	3	scenario	scenario	NN
cord-297078-pxggjaby	256	4	,	,	,
cord-297078-pxggjaby	256	5	cleavage	cleavage	NN
cord-297078-pxggjaby	256	6	-	-	HYPH
cord-297078-pxggjaby	256	7	stimulatory	stimulatory	JJ
cord-297078-pxggjaby	256	8	factors	factor	NNS
cord-297078-pxggjaby	256	9	evolved	evolve	VBD
cord-297078-pxggjaby	256	10	twice	twice	RB
cord-297078-pxggjaby	256	11	independently	independently	RB
cord-297078-pxggjaby	257	1	(	(	-LRB-
cord-297078-pxggjaby	257	2	GreA	GreA	NNP
cord-297078-pxggjaby	257	3	/	/	SYM
cord-297078-pxggjaby	257	4	GreB	GreB	NNP
cord-297078-pxggjaby	257	5	in	in	IN
cord-297078-pxggjaby	257	6	bacteria	bacteria	NNS
cord-297078-pxggjaby	257	7	and	and	CC
cord-297078-pxggjaby	257	8	transcription	transcription	NN
cord-297078-pxggjaby	257	9	factor	factor	NN
cord-297078-pxggjaby	258	1	S	S	NNP
cord-297078-pxggjaby	258	2	/	/	SYM
cord-297078-pxggjaby	258	3	TFIIS	TFIIS	NNP
cord-297078-pxggjaby	258	4	in	in	IN
cord-297078-pxggjaby	258	5	archaea	archaea	NNS
cord-297078-pxggjaby	258	6	/	/	SYM
cord-297078-pxggjaby	258	7	eukaryotes	eukaryote	NNS
cord-297078-pxggjaby	258	8	)	)	-RRB-
cord-297078-pxggjaby	258	9	with	with	IN
cord-297078-pxggjaby	258	10	an	an	DT
cord-297078-pxggjaby	258	11	initial	initial	JJ
cord-297078-pxggjaby	258	12	function	function	NN
cord-297078-pxggjaby	258	13	in	in	IN
cord-297078-pxggjaby	258	14	RNA	RNA	NNP
cord-297078-pxggjaby	258	15	genome	genome	NN
cord-297078-pxggjaby	258	16	repair	repair	NN
cord-297078-pxggjaby	258	17	.	.	.
cord-297078-pxggjaby	259	1	Subsequently	subsequently	RB
cord-297078-pxggjaby	259	2	,	,	,
cord-297078-pxggjaby	259	3	DNA	dna	NN
cord-297078-pxggjaby	259	4	replication	replication	NN
cord-297078-pxggjaby	259	5	could	could	MD
cord-297078-pxggjaby	259	6	have	have	VB
cord-297078-pxggjaby	259	7	evolved	evolve	VBN
cord-297078-pxggjaby	259	8	de	de	TO
cord-297078-pxggjaby	259	9	novo	novo	NNP
cord-297078-pxggjaby	259	10	twice	twice	RB
cord-297078-pxggjaby	259	11	independently	independently	RB
cord-297078-pxggjaby	259	12	,	,	,
cord-297078-pxggjaby	259	13	once	once	RB
cord-297078-pxggjaby	259	14	in	in	IN
cord-297078-pxggjaby	259	15	the	the	DT
cord-297078-pxggjaby	259	16	ancestor	ancestor	NN
cord-297078-pxggjaby	259	17	of	of	IN
cord-297078-pxggjaby	259	18	modern	modern	JJ
cord-297078-pxggjaby	259	19	bacteria	bacteria	NNS
cord-297078-pxggjaby	259	20	,	,	,
cord-297078-pxggjaby	259	21	and	and	CC
cord-297078-pxggjaby	259	22	once	once	RB
cord-297078-pxggjaby	259	23	in	in	IN
cord-297078-pxggjaby	259	24	the	the	DT
cord-297078-pxggjaby	259	25	ancestor	ancestor	NN
cord-297078-pxggjaby	259	26	of	of	IN
cord-297078-pxggjaby	259	27	archaea	archaea	NNS
cord-297078-pxggjaby	259	28	and	and	CC
cord-297078-pxggjaby	259	29	eukaryotes	eukaryote	NNS
cord-297078-pxggjaby	259	30	(	(	-LRB-
cord-297078-pxggjaby	259	31	fig	fig	NN
cord-297078-pxggjaby	259	32	.	.	NNP
cord-297078-pxggjaby	259	33	4	4	LS
cord-297078-pxggjaby	259	34	)	)	-RRB-
cord-297078-pxggjaby	259	35	.	.	.
cord-297078-pxggjaby	260	1	Alternatively	alternatively	RB
cord-297078-pxggjaby	260	2	,	,	,
cord-297078-pxggjaby	260	3	there	there	EX
cord-297078-pxggjaby	260	4	could	could	MD
cord-297078-pxggjaby	260	5	have	have	VB
cord-297078-pxggjaby	260	6	been	be	VBN
cord-297078-pxggjaby	260	7	transfer	transfer	NN
cord-297078-pxggjaby	260	8	of	of	IN
cord-297078-pxggjaby	260	9	a	a	DT
cord-297078-pxggjaby	260	10	complete	complete	JJ
cord-297078-pxggjaby	260	11	DNA	dna	NN
cord-297078-pxggjaby	260	12	replication	replication	NN
cord-297078-pxggjaby	260	13	apparatus	apparatus	NN
cord-297078-pxggjaby	260	14	plus	plus	IN
cord-297078-pxggjaby	260	15	deoxyribonucleotide	deoxyribonucleotide	JJ
cord-297078-pxggjaby	260	16	synthetic	synthetic	JJ
cord-297078-pxggjaby	260	17	enzymes	enzyme	NNS
cord-297078-pxggjaby	260	18	from	from	IN
cord-297078-pxggjaby	260	19	DNA	dna	NN
cord-297078-pxggjaby	260	20	viruses	virus	NNS
cord-297078-pxggjaby	260	21	,	,	,
cord-297078-pxggjaby	260	22	either	either	CC
cord-297078-pxggjaby	260	23	once	once	RB
cord-297078-pxggjaby	260	24	or	or	CC
cord-297078-pxggjaby	260	25	twice	twice	RB
cord-297078-pxggjaby	260	26	,	,	,
cord-297078-pxggjaby	260	27	being	be	VBG
cord-297078-pxggjaby	260	28	compatible	compatible	JJ
cord-297078-pxggjaby	260	29	with	with	IN
cord-297078-pxggjaby	260	30	either	either	DT
cord-297078-pxggjaby	260	31	scenario	scenario	NN
cord-297078-pxggjaby	260	32	shown	show	VBN
cord-297078-pxggjaby	260	33	in	in	IN
cord-297078-pxggjaby	260	34	figure	figure	NN
cord-297078-pxggjaby	260	35	4	4	CD
cord-297078-pxggjaby	260	36	(	(	-LRB-
cord-297078-pxggjaby	260	37	Forterre	Forterre	NNP
cord-297078-pxggjaby	260	38	2001	2001	CD
cord-297078-pxggjaby	260	39	(	(	-LRB-
cord-297078-pxggjaby	260	40	Forterre	Forterre	NNP
cord-297078-pxggjaby	260	41	,	,	,
cord-297078-pxggjaby	260	42	2002	2002	CD
cord-297078-pxggjaby	260	43	.	.	.
cord-297078-pxggjaby	261	1	Given	give	VBN
cord-297078-pxggjaby	261	2	that	that	DT
cord-297078-pxggjaby	261	3	replicative	replicative	JJ
cord-297078-pxggjaby	261	4	DNA	dna	NN
cord-297078-pxggjaby	261	5	polymerases	polymerase	NNS
cord-297078-pxggjaby	261	6	in	in	IN
cord-297078-pxggjaby	261	7	cellular	cellular	JJ
cord-297078-pxggjaby	261	8	lineages	lineage	NNS
cord-297078-pxggjaby	261	9	are	be	VBP
cord-297078-pxggjaby	261	10	unrelated	unrelated	JJ
cord-297078-pxggjaby	261	11	to	to	IN
cord-297078-pxggjaby	261	12	multisubunit	multisubunit	NNP
cord-297078-pxggjaby	261	13	RNA	RNA	NNP
cord-297078-pxggjaby	261	14	polymerases	polymerase	NNS
cord-297078-pxggjaby	261	15	,	,	,
cord-297078-pxggjaby	261	16	the	the	DT
cord-297078-pxggjaby	261	17	two	two	CD
cord-297078-pxggjaby	261	18	transfer	transfer	NN
cord-297078-pxggjaby	261	19	scenarios	scenario	NNS
cord-297078-pxggjaby	261	20	seem	seem	VBP
cord-297078-pxggjaby	261	21	likely	likely	RB
cord-297078-pxggjaby	261	22	,	,	,
cord-297078-pxggjaby	261	23	though	though	IN
cord-297078-pxggjaby	261	24	we	-PRON-	PRP
cord-297078-pxggjaby	261	25	note	note	VBP
cord-297078-pxggjaby	261	26	that	that	IN
cord-297078-pxggjaby	261	27	very	very	RB
cord-297078-pxggjaby	261	28	few	few	JJ
cord-297078-pxggjaby	261	29	examples	example	NNS
cord-297078-pxggjaby	261	30	of	of	IN
cord-297078-pxggjaby	261	31	C	c	NN
cord-297078-pxggjaby	261	32	-	-	HYPH
cord-297078-pxggjaby	261	33	family	family	NN
cord-297078-pxggjaby	261	34	polymerases	polymerase	NNS
cord-297078-pxggjaby	261	35	(	(	-LRB-
cord-297078-pxggjaby	261	36	bacterial	bacterial	JJ
cord-297078-pxggjaby	261	37	replicative	replicative	JJ
cord-297078-pxggjaby	261	38	DNA	dna	NN
cord-297078-pxggjaby	261	39	polymerases	polymerase	NNS
cord-297078-pxggjaby	261	40	)	)	-RRB-
cord-297078-pxggjaby	261	41	have	have	VBP
cord-297078-pxggjaby	261	42	been	be	VBN
cord-297078-pxggjaby	261	43	detected	detect	VBN
cord-297078-pxggjaby	261	44	in	in	IN
cord-297078-pxggjaby	261	45	viruses	virus	NNS
cord-297078-pxggjaby	261	46	or	or	CC
cord-297078-pxggjaby	261	47	plasmids	plasmid	NNS
cord-297078-pxggjaby	261	48	(	(	-LRB-
cord-297078-pxggjaby	261	49	Filée	Filée	NNP
cord-297078-pxggjaby	261	50	et	et	NNP
cord-297078-pxggjaby	261	51	al	al	NNP
cord-297078-pxggjaby	261	52	.	.	.
cord-297078-pxggjaby	261	53	2002	2002	CD
cord-297078-pxggjaby	261	54	)	)	-RRB-
cord-297078-pxggjaby	261	55	.	.	.
cord-297078-pxggjaby	262	1	Even	even	RB
cord-297078-pxggjaby	262	2	if	if	IN
cord-297078-pxggjaby	262	3	it	-PRON-	PRP
cord-297078-pxggjaby	262	4	could	could	MD
cord-297078-pxggjaby	262	5	be	be	VB
cord-297078-pxggjaby	262	6	shown	show	VBN
cord-297078-pxggjaby	262	7	that	that	IN
cord-297078-pxggjaby	262	8	the	the	DT
cord-297078-pxggjaby	262	9	genome	genome	NN
cord-297078-pxggjaby	262	10	of	of	IN
cord-297078-pxggjaby	262	11	LUCA	LUCA	NNP
cord-297078-pxggjaby	262	12	was	be	VBD
cord-297078-pxggjaby	262	13	DNA	DNA	NNP
cord-297078-pxggjaby	262	14	based	base	VBN
cord-297078-pxggjaby	262	15	and	and	CC
cord-297078-pxggjaby	262	16	that	that	IN
cord-297078-pxggjaby	262	17	proofreading	proofreading	NN
cord-297078-pxggjaby	262	18	and	and	CC
cord-297078-pxggjaby	262	19	repair	repair	NN
cord-297078-pxggjaby	262	20	of	of	IN
cord-297078-pxggjaby	262	21	DNA	dna	NN
cord-297078-pxggjaby	262	22	was	be	VBD
cord-297078-pxggjaby	262	23	a	a	DT
cord-297078-pxggjaby	262	24	constituent	constituent	JJ
cord-297078-pxggjaby	262	25	feature	feature	NN
cord-297078-pxggjaby	262	26	of	of	IN
cord-297078-pxggjaby	262	27	LUCA	LUCA	NNP
cord-297078-pxggjaby	262	28	,	,	,
cord-297078-pxggjaby	262	29	the	the	DT
cord-297078-pxggjaby	262	30	data	datum	NNS
cord-297078-pxggjaby	262	31	we	-PRON-	PRP
cord-297078-pxggjaby	262	32	have	have	VBP
cord-297078-pxggjaby	262	33	examined	examine	VBN
cord-297078-pxggjaby	262	34	nevertheless	nevertheless	RB
cord-297078-pxggjaby	262	35	point	point	NN
cord-297078-pxggjaby	262	36	to	to	IN
cord-297078-pxggjaby	262	37	RNA	RNA	NNP
cord-297078-pxggjaby	262	38	proofreading	proofreading	NN
cord-297078-pxggjaby	262	39	and	and	CC
cord-297078-pxggjaby	262	40	repair	repair	NN
cord-297078-pxggjaby	262	41	being	being	NN
cord-297078-pxggjaby	262	42	present	present	JJ
cord-297078-pxggjaby	262	43	in	in	IN
cord-297078-pxggjaby	262	44	LUCA	LUCA	NNP
cord-297078-pxggjaby	262	45	and	and	CC
cord-297078-pxggjaby	262	46	at	at	IN
cord-297078-pxggjaby	262	47	the	the	DT
cord-297078-pxggjaby	262	48	very	very	RB
cord-297078-pxggjaby	262	49	least	least	JJS
cord-297078-pxggjaby	262	50	indicate	indicate	VBP
cord-297078-pxggjaby	262	51	a	a	DT
cord-297078-pxggjaby	262	52	role	role	NN
cord-297078-pxggjaby	262	53	in	in	IN
cord-297078-pxggjaby	262	54	transcript	transcript	NN
cord-297078-pxggjaby	262	55	quality	quality	NN
cord-297078-pxggjaby	262	56	control	control	NN
cord-297078-pxggjaby	262	57	.	.	.
cord-297078-pxggjaby	263	1	Under	under	IN
cord-297078-pxggjaby	263	2	this	this	DT
cord-297078-pxggjaby	263	3	scenario	scenario	NN
cord-297078-pxggjaby	263	4	,	,	,
cord-297078-pxggjaby	263	5	genomic	genomic	JJ
cord-297078-pxggjaby	263	6	RNA	RNA	NNP
cord-297078-pxggjaby	263	7	repair	repair	NN
cord-297078-pxggjaby	263	8	should	should	MD
cord-297078-pxggjaby	263	9	still	still	RB
cord-297078-pxggjaby	263	10	be	be	VB
cord-297078-pxggjaby	263	11	considered	consider	VBN
cord-297078-pxggjaby	263	12	a	a	DT
cord-297078-pxggjaby	263	13	likely	likely	JJ
cord-297078-pxggjaby	263	14	step	step	NN
cord-297078-pxggjaby	263	15	in	in	IN
cord-297078-pxggjaby	263	16	the	the	DT
cord-297078-pxggjaby	263	17	RNA	RNA	NNP
cord-297078-pxggjaby	263	18	to	to	IN
cord-297078-pxggjaby	263	19	DNA	dna	NN
cord-297078-pxggjaby	263	20	transition	transition	NN
cord-297078-pxggjaby	263	21	,	,	,
cord-297078-pxggjaby	263	22	instead	instead	RB
cord-297078-pxggjaby	263	23	occurring	occur	VBG
cord-297078-pxggjaby	263	24	pre	pre	JJ
cord-297078-pxggjaby	263	25	-	-	NNP
cord-297078-pxggjaby	263	26	LUCA	LUCA	NNP
cord-297078-pxggjaby	263	27	.	.	.
cord-297078-pxggjaby	264	1	(	(	-LRB-
cord-297078-pxggjaby	264	2	Leipe	Leipe	NNP
cord-297078-pxggjaby	264	3	,	,	,
cord-297078-pxggjaby	264	4	Aravind	Aravind	NNP
cord-297078-pxggjaby	264	5	,	,	,
cord-297078-pxggjaby	264	6	and	and	CC
cord-297078-pxggjaby	264	7	Koonin	Koonin	NNP
cord-297078-pxggjaby	264	8	1999	1999	CD
cord-297078-pxggjaby	264	9	;	;	:
cord-297078-pxggjaby	264	10	Forterre	Forterre	NNP
cord-297078-pxggjaby	264	11	2002	2002	CD
cord-297078-pxggjaby	264	12	)	)	-RRB-
cord-297078-pxggjaby	264	13	have	have	VBP
cord-297078-pxggjaby	264	14	pointed	point	VBN
cord-297078-pxggjaby	264	15	out	out	RP
cord-297078-pxggjaby	264	16	that	that	IN
cord-297078-pxggjaby	264	17	the	the	DT
cord-297078-pxggjaby	264	18	DNA	dna	NN
cord-297078-pxggjaby	264	19	replication	replication	NN
cord-297078-pxggjaby	264	20	apparatus	apparatus	NN
cord-297078-pxggjaby	264	21	appears	appear	VBZ
cord-297078-pxggjaby	264	22	to	to	TO
cord-297078-pxggjaby	264	23	have	have	VB
cord-297078-pxggjaby	264	24	evolved	evolve	VBN
cord-297078-pxggjaby	264	25	twice	twice	RB
cord-297078-pxggjaby	264	26	,	,	,
cord-297078-pxggjaby	264	27	once	once	RB
cord-297078-pxggjaby	264	28	in	in	IN
cord-297078-pxggjaby	264	29	the	the	DT
cord-297078-pxggjaby	264	30	bacterial	bacterial	JJ
cord-297078-pxggjaby	264	31	lineage	lineage	NN
cord-297078-pxggjaby	264	32	and	and	CC
cord-297078-pxggjaby	264	33	once	once	RB
cord-297078-pxggjaby	264	34	in	in	IN
cord-297078-pxggjaby	264	35	the	the	DT
cord-297078-pxggjaby	264	36	archaeal	archaeal	JJ
cord-297078-pxggjaby	264	37	-	-	HYPH
cord-297078-pxggjaby	264	38	eukaryote	eukaryote	NN
cord-297078-pxggjaby	264	39	lineage	lineage	NN
cord-297078-pxggjaby	264	40	.	.	.
cord-297078-pxggjaby	265	1	This	this	DT
cord-297078-pxggjaby	265	2	implies	imply	VBZ
cord-297078-pxggjaby	265	3	that	that	IN
cord-297078-pxggjaby	265	4	the	the	DT
cord-297078-pxggjaby	265	5	LUCA	LUCA	NNP
cord-297078-pxggjaby	265	6	possessed	possess	VBD
cord-297078-pxggjaby	265	7	an	an	DT
cord-297078-pxggjaby	265	8	RNA	RNA	NNP
cord-297078-pxggjaby	265	9	genome	genome	NN
cord-297078-pxggjaby	265	10	,	,	,
cord-297078-pxggjaby	265	11	and	and	CC
cord-297078-pxggjaby	265	12	in	in	IN
cord-297078-pxggjaby	265	13	this	this	DT
cord-297078-pxggjaby	265	14	scenario	scenario	NN
cord-297078-pxggjaby	265	15	,	,	,
cord-297078-pxggjaby	265	16	bacterial	bacterial	JJ
cord-297078-pxggjaby	265	17	RNA	RNA	NNP
cord-297078-pxggjaby	265	18	polymerase	polymerase	NN
cord-297078-pxggjaby	265	19	-	-	HYPH
cord-297078-pxggjaby	265	20	associated	associate	VBN
cord-297078-pxggjaby	265	21	cleavage	cleavage	NN
cord-297078-pxggjaby	265	22	-	-	HYPH
cord-297078-pxggjaby	265	23	stimulatory	stimulatory	JJ
cord-297078-pxggjaby	265	24	factors	factor	NNS
cord-297078-pxggjaby	265	25	(	(	-LRB-
cord-297078-pxggjaby	265	26	GreA	GreA	NNP
cord-297078-pxggjaby	265	27	/	/	SYM
cord-297078-pxggjaby	265	28	GreB	GreB	NNP
cord-297078-pxggjaby	265	29	)	)	-RRB-
cord-297078-pxggjaby	265	30	and	and	CC
cord-297078-pxggjaby	265	31	their	-PRON-	PRP$
cord-297078-pxggjaby	265	32	archaeal	archaeal	JJ
cord-297078-pxggjaby	265	33	/	/	SYM
cord-297078-pxggjaby	265	34	eukaryotic	eukaryotic	JJ
cord-297078-pxggjaby	265	35	equivalents	equivalent	NNS
cord-297078-pxggjaby	265	36	(	(	-LRB-
cord-297078-pxggjaby	265	37	TFS	TFS	NNP
cord-297078-pxggjaby	265	38	/	/	SYM
cord-297078-pxggjaby	265	39	TFIIS	TFIIS	NNP
cord-297078-pxggjaby	265	40	)	)	-RRB-
cord-297078-pxggjaby	265	41	were	be	VBD
cord-297078-pxggjaby	265	42	originally	originally	RB
cord-297078-pxggjaby	265	43	involved	involve	VBN
cord-297078-pxggjaby	265	44	in	in	IN
cord-297078-pxggjaby	265	45	proofreading	proofreading	NN
cord-297078-pxggjaby	265	46	and	and	CC
cord-297078-pxggjaby	265	47	repair	repair	NN
cord-297078-pxggjaby	265	48	of	of	IN
cord-297078-pxggjaby	265	49	the	the	DT
cord-297078-pxggjaby	265	50	genome	genome	NN
cord-297078-pxggjaby	265	51	,	,	,
cord-297078-pxggjaby	265	52	as	as	IN
cord-297078-pxggjaby	265	53	indicated	indicate	VBN
cord-297078-pxggjaby	265	54	by	by	IN
cord-297078-pxggjaby	265	55	[	[	-LRB-
cord-297078-pxggjaby	265	56	Gen	Gen	NNP
cord-297078-pxggjaby	265	57	]	]	-RRB-
cord-297078-pxggjaby	265	58	.	.	.
cord-297078-pxggjaby	266	1	As	as	IN
cord-297078-pxggjaby	266	2	discussed	discuss	VBN
cord-297078-pxggjaby	266	3	in	in	IN
cord-297078-pxggjaby	266	4	the	the	DT
cord-297078-pxggjaby	266	5	text	text	NN
cord-297078-pxggjaby	266	6	,	,	,
cord-297078-pxggjaby	266	7	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	266	8	reductases	reductase	NNS
cord-297078-pxggjaby	266	9	have	have	VBP
cord-297078-pxggjaby	266	10	a	a	DT
cord-297078-pxggjaby	266	11	single	single	JJ
cord-297078-pxggjaby	266	12	origin	origin	NN
cord-297078-pxggjaby	266	13	,	,	,
cord-297078-pxggjaby	266	14	but	but	CC
cord-297078-pxggjaby	266	15	may	may	MD
cord-297078-pxggjaby	266	16	have	have	VB
cord-297078-pxggjaby	266	17	been	be	VBN
cord-297078-pxggjaby	266	18	subject	subject	JJ
cord-297078-pxggjaby	266	19	to	to	IN
cord-297078-pxggjaby	266	20	horizontal	horizontal	JJ
cord-297078-pxggjaby	266	21	gene	gene	NN
cord-297078-pxggjaby	266	22	transfer	transfer	NN
cord-297078-pxggjaby	266	23	,	,	,
cord-297078-pxggjaby	266	24	so	so	CC
cord-297078-pxggjaby	266	25	a	a	DT
cord-297078-pxggjaby	266	26	common	common	JJ
cord-297078-pxggjaby	266	27	origin	origin	NN
cord-297078-pxggjaby	266	28	is	be	VBZ
cord-297078-pxggjaby	266	29	not	not	RB
cord-297078-pxggjaby	266	30	necessarily	necessarily	RB
cord-297078-pxggjaby	266	31	inconsistent	inconsistent	JJ
cord-297078-pxggjaby	266	32	with	with	IN
cord-297078-pxggjaby	266	33	a	a	DT
cord-297078-pxggjaby	266	34	DNA	dna	NN
cord-297078-pxggjaby	266	35	genome	genome	NN
cord-297078-pxggjaby	266	36	evolving	evolve	VBG
cord-297078-pxggjaby	266	37	twice	twice	RB
cord-297078-pxggjaby	266	38	independently	independently	RB
cord-297078-pxggjaby	266	39	.	.	.
cord-297078-pxggjaby	267	1	(	(	-LRB-
cord-297078-pxggjaby	267	2	b	b	LS
cord-297078-pxggjaby	267	3	)	)	-RRB-
cord-297078-pxggjaby	267	4	LUCA	LUCA	NNP
cord-297078-pxggjaby	267	5	was	be	VBD
cord-297078-pxggjaby	267	6	DNA	DNA	NNP
cord-297078-pxggjaby	267	7	based	base	VBN
cord-297078-pxggjaby	267	8	.	.	.
cord-297078-pxggjaby	268	1	In	in	IN
cord-297078-pxggjaby	268	2	this	this	DT
cord-297078-pxggjaby	268	3	scenario	scenario	NN
cord-297078-pxggjaby	268	4	,	,	,
cord-297078-pxggjaby	268	5	one	one	CD
cord-297078-pxggjaby	268	6	of	of	IN
cord-297078-pxggjaby	268	7	the	the	DT
cord-297078-pxggjaby	268	8	extant	extant	JJ
cord-297078-pxggjaby	268	9	DNA	dna	NN
cord-297078-pxggjaby	268	10	replication	replication	NN
cord-297078-pxggjaby	268	11	machineries	machinery	NNS
cord-297078-pxggjaby	268	12	dates	date	VBZ
cord-297078-pxggjaby	268	13	back	back	RB
cord-297078-pxggjaby	268	14	to	to	IN
cord-297078-pxggjaby	268	15	LUCA	LUCA	NNP
cord-297078-pxggjaby	268	16	,	,	,
cord-297078-pxggjaby	268	17	while	while	IN
cord-297078-pxggjaby	268	18	the	the	DT
cord-297078-pxggjaby	268	19	other	other	JJ
cord-297078-pxggjaby	268	20	displaced	displace	VBD
cord-297078-pxggjaby	268	21	the	the	DT
cord-297078-pxggjaby	268	22	extant	extant	JJ
cord-297078-pxggjaby	268	23	(	(	-LRB-
cord-297078-pxggjaby	268	24	LUCA	LUCA	NNP
cord-297078-pxggjaby	268	25	)	)	-RRB-
cord-297078-pxggjaby	268	26	apparatus	apparatus	NN
cord-297078-pxggjaby	268	27	.	.	.
cord-297078-pxggjaby	269	1	In	in	IN
cord-297078-pxggjaby	269	2	the	the	DT
cord-297078-pxggjaby	269	3	figure	figure	NN
cord-297078-pxggjaby	269	4	,	,	,
cord-297078-pxggjaby	269	5	the	the	DT
cord-297078-pxggjaby	269	6	archaeoeukaryotic	archaeoeukaryotic	JJ
cord-297078-pxggjaby	269	7	apparatus	apparatus	NN
cord-297078-pxggjaby	269	8	is	be	VBZ
cord-297078-pxggjaby	269	9	depicted	depict	VBN
cord-297078-pxggjaby	269	10	as	as	IN
cord-297078-pxggjaby	269	11	ancestral	ancestral	JJ
cord-297078-pxggjaby	269	12	,	,	,
cord-297078-pxggjaby	269	13	but	but	CC
cord-297078-pxggjaby	269	14	it	-PRON-	PRP
cord-297078-pxggjaby	269	15	is	be	VBZ
cord-297078-pxggjaby	269	16	equally	equally	RB
cord-297078-pxggjaby	269	17	possible	possible	JJ
cord-297078-pxggjaby	269	18	that	that	IN
cord-297078-pxggjaby	269	19	the	the	DT
cord-297078-pxggjaby	269	20	bacterial	bacterial	JJ
cord-297078-pxggjaby	269	21	apparatus	apparatus	NN
cord-297078-pxggjaby	269	22	is	be	VBZ
cord-297078-pxggjaby	269	23	ancestral	ancestral	JJ
cord-297078-pxggjaby	269	24	.	.	.
cord-297078-pxggjaby	270	1	The	the	DT
cord-297078-pxggjaby	270	2	source	source	NN
cord-297078-pxggjaby	270	3	of	of	IN
cord-297078-pxggjaby	270	4	a	a	DT
cord-297078-pxggjaby	270	5	second	second	JJ
cord-297078-pxggjaby	270	6	replication	replication	NN
cord-297078-pxggjaby	270	7	apparatus	apparatus	NN
cord-297078-pxggjaby	270	8	is	be	VBZ
cord-297078-pxggjaby	270	9	unclear	unclear	JJ
cord-297078-pxggjaby	270	10	but	but	CC
cord-297078-pxggjaby	270	11	has	have	VBZ
cord-297078-pxggjaby	270	12	been	be	VBN
cord-297078-pxggjaby	270	13	suggested	suggest	VBN
cord-297078-pxggjaby	270	14	to	to	TO
cord-297078-pxggjaby	270	15	be	be	VB
cord-297078-pxggjaby	270	16	viral	viral	JJ
cord-297078-pxggjaby	270	17	in	in	IN
cord-297078-pxggjaby	270	18	origin	origin	NN
cord-297078-pxggjaby	270	19	.	.	.
cord-297078-pxggjaby	271	1	Under	under	IN
cord-297078-pxggjaby	271	2	a	a	DT
cord-297078-pxggjaby	271	3	DNA	DNA	NNP
cord-297078-pxggjaby	271	4	-	-	HYPH
cord-297078-pxggjaby	271	5	LUCA	LUCA	NNP
cord-297078-pxggjaby	271	6	,	,	,
cord-297078-pxggjaby	271	7	the	the	DT
cord-297078-pxggjaby	271	8	cleavage	cleavage	NN
cord-297078-pxggjaby	271	9	-	-	HYPH
cord-297078-pxggjaby	271	10	stimulatory	stimulatory	JJ
cord-297078-pxggjaby	271	11	factors	factor	NNS
cord-297078-pxggjaby	271	12	would	would	MD
cord-297078-pxggjaby	271	13	have	have	VB
cord-297078-pxggjaby	271	14	evolved	evolve	VBN
cord-297078-pxggjaby	271	15	twice	twice	RB
cord-297078-pxggjaby	271	16	independently	independently	RB
cord-297078-pxggjaby	271	17	in	in	IN
cord-297078-pxggjaby	271	18	mRNA	mRNA	NNP
cord-297078-pxggjaby	271	19	quality	quality	NN
cord-297078-pxggjaby	271	20	control	control	NN
cord-297078-pxggjaby	271	21	[	[	-LRB-
cord-297078-pxggjaby	271	22	QC	QC	NNP
cord-297078-pxggjaby	271	23	]	]	-RRB-
cord-297078-pxggjaby	271	24	,	,	,
cord-297078-pxggjaby	271	25	which	which	WDT
cord-297078-pxggjaby	271	26	is	be	VBZ
cord-297078-pxggjaby	271	27	their	-PRON-	PRP$
cord-297078-pxggjaby	271	28	current	current	JJ
cord-297078-pxggjaby	271	29	function	function	NN
cord-297078-pxggjaby	271	30	.	.	.
cord-297078-pxggjaby	272	1	A	a	DT
cord-297078-pxggjaby	272	2	DNA	DNA	NNP
cord-297078-pxggjaby	272	3	-	-	HYPH
cord-297078-pxggjaby	272	4	LUCA	LUCA	NNP
cord-297078-pxggjaby	272	5	implies	imply	VBZ
cord-297078-pxggjaby	272	6	that	that	IN
cord-297078-pxggjaby	272	7	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	272	8	reductase	reductase	NN
cord-297078-pxggjaby	272	9	was	be	VBD
cord-297078-pxggjaby	272	10	present	present	JJ
cord-297078-pxggjaby	272	11	in	in	IN
cord-297078-pxggjaby	272	12	LUCA	LUCA	NNP
cord-297078-pxggjaby	272	13	and	and	CC
cord-297078-pxggjaby	272	14	that	that	IN
cord-297078-pxggjaby	272	15	it	-PRON-	PRP
cord-297078-pxggjaby	272	16	this	this	DT
cord-297078-pxggjaby	272	17	family	family	NN
cord-297078-pxggjaby	272	18	of	of	IN
cord-297078-pxggjaby	272	19	enzymes	enzyme	NNS
cord-297078-pxggjaby	272	20	have	have	VBP
cord-297078-pxggjaby	272	21	subsequently	subsequently	RB
cord-297078-pxggjaby	272	22	been	be	VBN
cord-297078-pxggjaby	272	23	subject	subject	JJ
cord-297078-pxggjaby	272	24	to	to	IN
cord-297078-pxggjaby	272	25	horizontal	horizontal	JJ
cord-297078-pxggjaby	272	26	gene	gene	NN
cord-297078-pxggjaby	272	27	transfer	transfer	NN
cord-297078-pxggjaby	272	28	,	,	,
cord-297078-pxggjaby	272	29	thereby	thereby	RB
cord-297078-pxggjaby	272	30	obscuring	obscure	VBG
cord-297078-pxggjaby	272	31	their	-PRON-	PRP$
cord-297078-pxggjaby	272	32	early	early	JJ
cord-297078-pxggjaby	272	33	origin	origin	NN
cord-297078-pxggjaby	272	34	.	.	.
cord-297078-pxggjaby	273	1	Note	note	VB
cord-297078-pxggjaby	273	2	also	also	RB
cord-297078-pxggjaby	273	3	that	that	IN
cord-297078-pxggjaby	273	4	the	the	DT
cord-297078-pxggjaby	273	5	cleavage	cleavage	NN
cord-297078-pxggjaby	273	6	-	-	HYPH
cord-297078-pxggjaby	273	7	stimulatory	stimulatory	JJ
cord-297078-pxggjaby	273	8	factors	factor	NNS
cord-297078-pxggjaby	273	9	could	could	MD
cord-297078-pxggjaby	273	10	have	have	VB
cord-297078-pxggjaby	273	11	been	be	VBN
cord-297078-pxggjaby	273	12	subject	subject	JJ
cord-297078-pxggjaby	273	13	to	to	IN
cord-297078-pxggjaby	273	14	NOGD	NOGD	NNP
cord-297078-pxggjaby	273	15	,	,	,
cord-297078-pxggjaby	273	16	mirroring	mirror	VBG
cord-297078-pxggjaby	273	17	the	the	DT
cord-297078-pxggjaby	273	18	events	event	NNS
cord-297078-pxggjaby	273	19	depicted	depict	VBN
cord-297078-pxggjaby	273	20	for	for	IN
cord-297078-pxggjaby	273	21	the	the	DT
cord-297078-pxggjaby	273	22	DNA	dna	NN
cord-297078-pxggjaby	273	23	replication	replication	NN
cord-297078-pxggjaby	273	24	apparatuses	apparatus	NNS
cord-297078-pxggjaby	273	25	,	,	,
cord-297078-pxggjaby	273	26	though	though	RB
cord-297078-pxggjaby	273	27	for	for	IN
cord-297078-pxggjaby	273	28	simplicity	simplicity	NN
cord-297078-pxggjaby	273	29	,	,	,
cord-297078-pxggjaby	273	30	this	this	DT
cord-297078-pxggjaby	273	31	is	be	VBZ
cord-297078-pxggjaby	273	32	not	not	RB
cord-297078-pxggjaby	273	33	shown	show	VBN
cord-297078-pxggjaby	273	34	.	.	.
cord-297078-pxggjaby	274	1	Note	note	VB
cord-297078-pxggjaby	274	2	that	that	IN
cord-297078-pxggjaby	274	3	,	,	,
cord-297078-pxggjaby	274	4	the	the	DT
cord-297078-pxggjaby	274	5	scenario	scenario	NN
cord-297078-pxggjaby	274	6	in	in	IN
cord-297078-pxggjaby	274	7	panel	panel	NN
cord-297078-pxggjaby	274	8	(	(	-LRB-
cord-297078-pxggjaby	274	9	a	a	LS
cord-297078-pxggjaby	274	10	)	)	-RRB-
cord-297078-pxggjaby	274	11	is	be	VBZ
cord-297078-pxggjaby	274	12	reconcilable	reconcilable	JJ
cord-297078-pxggjaby	274	13	with	with	IN
cord-297078-pxggjaby	274	14	two	two	CD
cord-297078-pxggjaby	274	15	independent	independent	JJ
cord-297078-pxggjaby	274	16	viral	viral	JJ
cord-297078-pxggjaby	274	17	transfers	transfer	NNS
cord-297078-pxggjaby	274	18	but	but	CC
cord-297078-pxggjaby	274	19	requires	require	VBZ
cord-297078-pxggjaby	274	20	more	more	JJR
cord-297078-pxggjaby	274	21	events	event	NNS
cord-297078-pxggjaby	274	22	than	than	IN
cord-297078-pxggjaby	274	23	either	either	DT
cord-297078-pxggjaby	274	24	of	of	IN
cord-297078-pxggjaby	274	25	the	the	DT
cord-297078-pxggjaby	274	26	depicted	depict	VBN
cord-297078-pxggjaby	274	27	scenarios	scenario	NNS
cord-297078-pxggjaby	274	28	.	.	.
cord-297078-pxggjaby	275	1	For	for	IN
cord-297078-pxggjaby	275	2	completeness	completeness	NN
cord-297078-pxggjaby	275	3	,	,	,
cord-297078-pxggjaby	275	4	the	the	DT
cord-297078-pxggjaby	275	5	evolutionary	evolutionary	JJ
cord-297078-pxggjaby	275	6	relationship	relationship	NN
cord-297078-pxggjaby	275	7	between	between	IN
cord-297078-pxggjaby	275	8	eukaryote	eukaryote	NN
cord-297078-pxggjaby	275	9	nuclear	nuclear	JJ
cord-297078-pxggjaby	275	10	genes	gene	NNS
cord-297078-pxggjaby	275	11	and	and	CC
cord-297078-pxggjaby	275	12	counterparts	counterpart	NNS
cord-297078-pxggjaby	275	13	in	in	IN
cord-297078-pxggjaby	275	14	archaea	archaea	NNS
cord-297078-pxggjaby	275	15	and	and	CC
cord-297078-pxggjaby	275	16	bacteria	bacteria	NNS
cord-297078-pxggjaby	275	17	,	,	,
cord-297078-pxggjaby	275	18	the	the	DT
cord-297078-pxggjaby	275	19	latter	latter	JJ
cord-297078-pxggjaby	275	20	being	being	NN
cord-297078-pxggjaby	275	21	of	of	IN
cord-297078-pxggjaby	275	22	mitochondrial	mitochondrial	JJ
cord-297078-pxggjaby	275	23	endosymbiotic	endosymbiotic	JJ
cord-297078-pxggjaby	275	24	origin	origin	NN
cord-297078-pxggjaby	276	1	(	(	-LRB-
cord-297078-pxggjaby	276	2	Esser	Esser	NNP
cord-297078-pxggjaby	276	3	et	et	FW
cord-297078-pxggjaby	276	4	al	al	NNP
cord-297078-pxggjaby	276	5	.	.	.
cord-297078-pxggjaby	276	6	2004	2004	CD
cord-297078-pxggjaby	276	7	)	)	-RRB-
cord-297078-pxggjaby	276	8	,	,	,
cord-297078-pxggjaby	276	9	is	be	VBZ
cord-297078-pxggjaby	276	10	displayed	display	VBN
cord-297078-pxggjaby	276	11	.	.	.
cord-297078-pxggjaby	277	1	However	however	RB
cord-297078-pxggjaby	277	2	,	,	,
cord-297078-pxggjaby	277	3	the	the	DT
cord-297078-pxggjaby	277	4	eukaryotic	eukaryotic	JJ
cord-297078-pxggjaby	277	5	replication	replication	NN
cord-297078-pxggjaby	277	6	apparatus	apparatus	NN
cord-297078-pxggjaby	277	7	is	be	VBZ
cord-297078-pxggjaby	277	8	related	relate	VBN
cord-297078-pxggjaby	277	9	to	to	IN
cord-297078-pxggjaby	277	10	the	the	DT
cord-297078-pxggjaby	277	11	archaeal	archaeal	JJ
cord-297078-pxggjaby	277	12	apparatus	apparatus	NN
cord-297078-pxggjaby	277	13	,	,	,
cord-297078-pxggjaby	277	14	not	not	RB
cord-297078-pxggjaby	277	15	the	the	DT
cord-297078-pxggjaby	277	16	bacterial	bacterial	JJ
cord-297078-pxggjaby	277	17	,	,	,
cord-297078-pxggjaby	277	18	excepting	except	VBG
cord-297078-pxggjaby	277	19	universal	universal	JJ
cord-297078-pxggjaby	277	20	components	component	NNS
cord-297078-pxggjaby	277	21	(	(	-LRB-
cord-297078-pxggjaby	277	22	see	see	VB
cord-297078-pxggjaby	277	23	text	text	NN
cord-297078-pxggjaby	277	24	)	)	-RRB-
cord-297078-pxggjaby	277	25	.	.	.
cord-297078-pxggjaby	278	1	In	in	IN
cord-297078-pxggjaby	278	2	conclusion	conclusion	NN
cord-297078-pxggjaby	278	3	,	,	,
cord-297078-pxggjaby	278	4	we	-PRON-	PRP
cord-297078-pxggjaby	278	5	maintain	maintain	VBP
cord-297078-pxggjaby	278	6	that	that	IN
cord-297078-pxggjaby	278	7	RNA	RNA	NNP
cord-297078-pxggjaby	278	8	polymerasedependent	polymerasedependent	NN
cord-297078-pxggjaby	278	9	repair	repair	NN
cord-297078-pxggjaby	278	10	of	of	IN
cord-297078-pxggjaby	278	11	genetic	genetic	JJ
cord-297078-pxggjaby	278	12	material	material	NN
cord-297078-pxggjaby	278	13	is	be	VBZ
cord-297078-pxggjaby	278	14	likely	likely	JJ
cord-297078-pxggjaby	278	15	to	to	TO
cord-297078-pxggjaby	278	16	have	have	VB
cord-297078-pxggjaby	278	17	been	be	VBN
cord-297078-pxggjaby	278	18	a	a	DT
cord-297078-pxggjaby	278	19	crucial	crucial	JJ
cord-297078-pxggjaby	278	20	step	step	NN
cord-297078-pxggjaby	278	21	in	in	IN
cord-297078-pxggjaby	278	22	the	the	DT
cord-297078-pxggjaby	278	23	evolution	evolution	NN
cord-297078-pxggjaby	278	24	of	of	IN
cord-297078-pxggjaby	278	25	complex	complex	JJ
cord-297078-pxggjaby	278	26	RNA	RNA	NNP
cord-297078-pxggjaby	278	27	-	-	:
cord-297078-pxggjaby	278	28	and	and	CC
cord-297078-pxggjaby	278	29	protein	protein	NN
cord-297078-pxggjaby	278	30	-	-	HYPH
cord-297078-pxggjaby	278	31	based	base	VBN
cord-297078-pxggjaby	278	32	cells	cell	NNS
cord-297078-pxggjaby	278	33	.	.	.
cord-297078-pxggjaby	279	1	Recent	recent	JJ
cord-297078-pxggjaby	279	2	data	datum	NNS
cord-297078-pxggjaby	279	3	from	from	IN
cord-297078-pxggjaby	279	4	comparative	comparative	JJ
cord-297078-pxggjaby	279	5	genomics	genomic	NNS
cord-297078-pxggjaby	279	6	have	have	VBP
cord-297078-pxggjaby	279	7	made	make	VBN
cord-297078-pxggjaby	279	8	clear	clear	JJ
cord-297078-pxggjaby	279	9	the	the	DT
cord-297078-pxggjaby	279	10	difficulty	difficulty	NN
cord-297078-pxggjaby	279	11	in	in	IN
cord-297078-pxggjaby	279	12	establishing	establish	VBG
cord-297078-pxggjaby	279	13	whether	whether	IN
cord-297078-pxggjaby	279	14	DNA	DNA	NNP
cord-297078-pxggjaby	279	15	was	be	VBD
cord-297078-pxggjaby	279	16	present	present	JJ
cord-297078-pxggjaby	279	17	in	in	IN
cord-297078-pxggjaby	279	18	LUCA	LUCA	NNP
cord-297078-pxggjaby	279	19	,	,	,
cord-297078-pxggjaby	279	20	and	and	CC
cord-297078-pxggjaby	279	21	consequently	consequently	RB
cord-297078-pxggjaby	279	22	,	,	,
cord-297078-pxggjaby	279	23	insights	insight	NNS
cord-297078-pxggjaby	279	24	into	into	IN
cord-297078-pxggjaby	279	25	early	early	JJ
cord-297078-pxggjaby	279	26	mechanisms	mechanism	NNS
cord-297078-pxggjaby	279	27	of	of	IN
cord-297078-pxggjaby	279	28	RNA	RNA	NNP
cord-297078-pxggjaby	279	29	repair	repair	NN
cord-297078-pxggjaby	279	30	are	be	VBP
cord-297078-pxggjaby	279	31	as	as	RB
cord-297078-pxggjaby	279	32	important	important	JJ
cord-297078-pxggjaby	279	33	to	to	IN
cord-297078-pxggjaby	279	34	the	the	DT
cord-297078-pxggjaby	279	35	reconstruction	reconstruction	NN
cord-297078-pxggjaby	279	36	of	of	IN
cord-297078-pxggjaby	279	37	LUCA	LUCA	NNP
cord-297078-pxggjaby	279	38	as	as	IN
cord-297078-pxggjaby	279	39	they	-PRON-	PRP
cord-297078-pxggjaby	279	40	are	be	VBP
cord-297078-pxggjaby	279	41	to	to	IN
cord-297078-pxggjaby	279	42	the	the	DT
cord-297078-pxggjaby	279	43	RNA	RNA	NNP
cord-297078-pxggjaby	279	44	to	to	IN
cord-297078-pxggjaby	279	45	DNA	dna	NN
cord-297078-pxggjaby	279	46	transition	transition	NN
cord-297078-pxggjaby	279	47	.	.	.
cord-297078-pxggjaby	280	1	This	this	DT
cord-297078-pxggjaby	280	2	work	work	NN
cord-297078-pxggjaby	280	3	was	be	VBD
cord-297078-pxggjaby	280	4	supported	support	VBN
cord-297078-pxggjaby	280	5	by	by	IN
cord-297078-pxggjaby	280	6	grants	grant	NNS
cord-297078-pxggjaby	280	7	to	to	IN
cord-297078-pxggjaby	280	8	A.M.P.	A.M.P.	NNP
cord-297078-pxggjaby	280	9	from	from	IN
cord-297078-pxggjaby	280	10	the	the	DT
cord-297078-pxggjaby	280	11	Swedish	Swedish	NNP
cord-297078-pxggjaby	280	12	Research	Research	NNP
cord-297078-pxggjaby	280	13	Council	Council	NNP
cord-297078-pxggjaby	280	14	(	(	-LRB-
cord-297078-pxggjaby	280	15	Vetenskapsrådet	Vetenskapsrådet	NNP
cord-297078-pxggjaby	280	16	)	)	-RRB-
cord-297078-pxggjaby	280	17	and	and	CC
cord-297078-pxggjaby	280	18	the	the	DT
cord-297078-pxggjaby	280	19	Knut	Knut	NNP
cord-297078-pxggjaby	280	20	and	and	CC
cord-297078-pxggjaby	280	21	Alice	Alice	NNP
cord-297078-pxggjaby	280	22	Wallenberg	Wallenberg	NNP
cord-297078-pxggjaby	280	23	Foundation	Foundation	NNP
cord-297078-pxggjaby	280	24	and	and	CC
cord-297078-pxggjaby	280	25	to	to	IN
cord-297078-pxggjaby	280	26	D.T.L.	D.T.L.	NNP
cord-297078-pxggjaby	280	27	from	from	IN
cord-297078-pxggjaby	280	28	Vetenskapsrådet	Vetenskapsrådet	NNP
cord-297078-pxggjaby	280	29	.	.	.
cord-297078-pxggjaby	281	1	We	-PRON-	PRP
cord-297078-pxggjaby	281	2	thank	thank	VBP
cord-297078-pxggjaby	281	3	Patrick	Patrick	NNP
cord-297078-pxggjaby	281	4	Forterre	Forterre	NNP
cord-297078-pxggjaby	281	5	for	for	IN
cord-297078-pxggjaby	281	6	valuable	valuable	JJ
cord-297078-pxggjaby	281	7	comments	comment	NNS
cord-297078-pxggjaby	281	8	on	on	IN
cord-297078-pxggjaby	281	9	an	an	DT
cord-297078-pxggjaby	281	10	early	early	JJ
cord-297078-pxggjaby	281	11	version	version	NN
cord-297078-pxggjaby	281	12	of	of	IN
cord-297078-pxggjaby	281	13	the	the	DT
cord-297078-pxggjaby	281	14	manuscript	manuscript	NN
cord-297078-pxggjaby	281	15	and	and	CC
cord-297078-pxggjaby	281	16	for	for	IN
cord-297078-pxggjaby	281	17	sending	send	VBG
cord-297078-pxggjaby	281	18	preprints	preprint	NNS
cord-297078-pxggjaby	281	19	,	,	,
cord-297078-pxggjaby	281	20	Seth	Seth	NNP
cord-297078-pxggjaby	281	21	Darst	Darst	NNP
cord-297078-pxggjaby	281	22	for	for	IN
cord-297078-pxggjaby	281	23	providing	provide	VBG
cord-297078-pxggjaby	281	24	side	side	NN
cord-297078-pxggjaby	281	25	-	-	HYPH
cord-297078-pxggjaby	281	26	chain	chain	NN
cord-297078-pxggjaby	281	27	coordinates	coordinate	NNS
cord-297078-pxggjaby	281	28	for	for	IN
cord-297078-pxggjaby	281	29	the	the	DT
cord-297078-pxggjaby	281	30	RNAP	RNAP	NNP
cord-297078-pxggjaby	281	31	/	/	SYM
cord-297078-pxggjaby	281	32	GreB	GreB	NNP
cord-297078-pxggjaby	281	33	complex	complex	NN
cord-297078-pxggjaby	281	34	,	,	,
cord-297078-pxggjaby	281	35	and	and	CC
cord-297078-pxggjaby	281	36	two	two	CD
cord-297078-pxggjaby	281	37	anonymous	anonymous	JJ
cord-297078-pxggjaby	281	38	reviewers	reviewer	NNS
cord-297078-pxggjaby	281	39	for	for	IN
cord-297078-pxggjaby	281	40	helpful	helpful	JJ
cord-297078-pxggjaby	281	41	comments	comment	NNS
cord-297078-pxggjaby	281	42	on	on	IN
cord-297078-pxggjaby	281	43	the	the	DT
cord-297078-pxggjaby	281	44	manuscript	manuscript	NN
cord-297078-pxggjaby	281	45	.	.	.
cord-297078-pxggjaby	282	1	As	as	IN
cord-297078-pxggjaby	282	2	summarized	summarize	VBN
cord-297078-pxggjaby	282	3	in	in	IN
cord-297078-pxggjaby	282	4	the	the	DT
cord-297078-pxggjaby	282	5	table	table	NN
cord-297078-pxggjaby	282	6	below	below	RB
cord-297078-pxggjaby	282	7	,	,	,
cord-297078-pxggjaby	282	8	two	two	CD
cord-297078-pxggjaby	282	9	additional	additional	JJ
cord-297078-pxggjaby	282	10	forms	form	NNS
cord-297078-pxggjaby	282	11	of	of	IN
cord-297078-pxggjaby	282	12	RNA	RNA	NNP
cord-297078-pxggjaby	282	13	repair	repair	NN
cord-297078-pxggjaby	282	14	have	have	VBP
cord-297078-pxggjaby	282	15	been	be	VBN
cord-297078-pxggjaby	282	16	reported	report	VBN
cord-297078-pxggjaby	282	17	;	;	:
cord-297078-pxggjaby	282	18	transfer	transfer	VB
cord-297078-pxggjaby	282	19	RNA	RNA	NNP
cord-297078-pxggjaby	282	20	(	(	-LRB-
cord-297078-pxggjaby	282	21	tRNA	tRNA	NNP
cord-297078-pxggjaby	282	22	)	)	-RRB-
cord-297078-pxggjaby	282	23	repair	repair	NN
cord-297078-pxggjaby	282	24	and	and	CC
cord-297078-pxggjaby	282	25	repair	repair	NN
cord-297078-pxggjaby	282	26	of	of	IN
cord-297078-pxggjaby	282	27	methyl	methyl	NN
cord-297078-pxggjaby	282	28	-	-	HYPH
cord-297078-pxggjaby	282	29	damaged	damage	VBN
cord-297078-pxggjaby	282	30	RNA	RNA	NNP
cord-297078-pxggjaby	282	31	.	.	.
cord-297078-pxggjaby	283	1	tRNA	tRNA	NNP
cord-297078-pxggjaby	283	2	Repair	Repair	NNP
cord-297078-pxggjaby	283	3	tRNA	tRNA	NNP
cord-297078-pxggjaby	283	4	repair	repair	NN
cord-297078-pxggjaby	283	5	is	be	VBZ
cord-297078-pxggjaby	283	6	so	so	RB
cord-297078-pxggjaby	283	7	far	far	RB
cord-297078-pxggjaby	283	8	restricted	restricted	JJ
cord-297078-pxggjaby	283	9	to	to	IN
cord-297078-pxggjaby	283	10	mammalian	mammalian	JJ
cord-297078-pxggjaby	283	11	mitochondria	mitochondrion	NNS
cord-297078-pxggjaby	283	12	.	.	.
cord-297078-pxggjaby	284	1	Here	here	RB
cord-297078-pxggjaby	284	2	overlapping	overlap	VBG
cord-297078-pxggjaby	284	3	tRNAs	trna	NNS
cord-297078-pxggjaby	284	4	are	be	VBP
cord-297078-pxggjaby	284	5	expressed	express	VBN
cord-297078-pxggjaby	284	6	as	as	IN
cord-297078-pxggjaby	284	7	a	a	DT
cord-297078-pxggjaby	284	8	single	single	JJ
cord-297078-pxggjaby	284	9	molecule	molecule	NN
cord-297078-pxggjaby	284	10	that	that	WDT
cord-297078-pxggjaby	284	11	is	be	VBZ
cord-297078-pxggjaby	284	12	processed	process	VBN
cord-297078-pxggjaby	284	13	such	such	JJ
cord-297078-pxggjaby	284	14	that	that	IN
cord-297078-pxggjaby	284	15	the	the	DT
cord-297078-pxggjaby	284	16	downstream	downstream	JJ
cord-297078-pxggjaby	284	17	tRNA	trna	NN
cord-297078-pxggjaby	284	18	is	be	VBZ
cord-297078-pxggjaby	284	19	complete	complete	JJ
cord-297078-pxggjaby	284	20	,	,	,
cord-297078-pxggjaby	284	21	leaving	leave	VBG
cord-297078-pxggjaby	284	22	the	the	DT
cord-297078-pxggjaby	284	23	upstream	upstream	JJ
cord-297078-pxggjaby	284	24	tRNA	trna	NN
cord-297078-pxggjaby	284	25	in	in	IN
cord-297078-pxggjaby	284	26	a	a	DT
cord-297078-pxggjaby	284	27	truncated	truncated	JJ
cord-297078-pxggjaby	284	28	form	form	NN
cord-297078-pxggjaby	284	29	which	which	WDT
cord-297078-pxggjaby	284	30	must	must	MD
cord-297078-pxggjaby	284	31	be	be	VB
cord-297078-pxggjaby	284	32	'	'	``
cord-297078-pxggjaby	284	33	'	'	``
cord-297078-pxggjaby	284	34	repaired	repair	VBN
cord-297078-pxggjaby	284	35	'	'	''
cord-297078-pxggjaby	284	36	'	'	''
cord-297078-pxggjaby	284	37	by	by	IN
cord-297078-pxggjaby	284	38	extending	extend	VBG
cord-297078-pxggjaby	284	39	the	the	DT
cord-297078-pxggjaby	284	40	3	3	CD
cord-297078-pxggjaby	284	41	#	#	NN
cord-297078-pxggjaby	284	42	end	end	NN
cord-297078-pxggjaby	285	1	(	(	-LRB-
cord-297078-pxggjaby	285	2	Reichert	Reichert	NNP
cord-297078-pxggjaby	285	3	and	and	CC
cord-297078-pxggjaby	285	4	Mörl	Mörl	NNP
cord-297078-pxggjaby	285	5	2000	2000	CD
cord-297078-pxggjaby	285	6	)	)	-RRB-
cord-297078-pxggjaby	285	7	.	.	.
cord-297078-pxggjaby	286	1	This	this	DT
cord-297078-pxggjaby	286	2	tRNA	trna	NN
cord-297078-pxggjaby	286	3	'	'	''
cord-297078-pxggjaby	286	4	'	'	``
cord-297078-pxggjaby	286	5	completion	completion	NN
cord-297078-pxggjaby	286	6	'	'	''
cord-297078-pxggjaby	286	7	'	'	''
cord-297078-pxggjaby	286	8	seems	seem	VBZ
cord-297078-pxggjaby	286	9	to	to	TO
cord-297078-pxggjaby	286	10	occur	occur	VB
cord-297078-pxggjaby	286	11	in	in	IN
cord-297078-pxggjaby	286	12	the	the	DT
cord-297078-pxggjaby	286	13	absence	absence	NN
cord-297078-pxggjaby	286	14	of	of	IN
cord-297078-pxggjaby	286	15	a	a	DT
cord-297078-pxggjaby	286	16	template	template	NN
cord-297078-pxggjaby	286	17	,	,	,
cord-297078-pxggjaby	286	18	leading	lead	VBG
cord-297078-pxggjaby	286	19	to	to	IN
cord-297078-pxggjaby	286	20	speculation	speculation	NN
cord-297078-pxggjaby	286	21	that	that	IN
cord-297078-pxggjaby	286	22	it	-PRON-	PRP
cord-297078-pxggjaby	286	23	works	work	VBZ
cord-297078-pxggjaby	286	24	by	by	IN
cord-297078-pxggjaby	286	25	trial	trial	NN
cord-297078-pxggjaby	286	26	and	and	CC
cord-297078-pxggjaby	286	27	error	error	NN
cord-297078-pxggjaby	287	1	-tRNAs	-tRNAs	:
cord-297078-pxggjaby	287	2	with	with	IN
cord-297078-pxggjaby	287	3	an	an	DT
cord-297078-pxggjaby	287	4	incorrect	incorrect	JJ
cord-297078-pxggjaby	287	5	3	3	CD
cord-297078-pxggjaby	287	6	#	#	NN
cord-297078-pxggjaby	287	7	sequence	sequence	NN
cord-297078-pxggjaby	287	8	are	be	VBP
cord-297078-pxggjaby	287	9	degraded	degrade	VBN
cord-297078-pxggjaby	287	10	by	by	IN
cord-297078-pxggjaby	287	11	exonuclease	exonuclease	NN
cord-297078-pxggjaby	287	12	activity	activity	NN
cord-297078-pxggjaby	287	13	and	and	CC
cord-297078-pxggjaby	287	14	reelongated	reelongate	VBN
cord-297078-pxggjaby	287	15	;	;	:
cord-297078-pxggjaby	287	16	when	when	WRB
cord-297078-pxggjaby	287	17	the	the	DT
cord-297078-pxggjaby	287	18	correct	correct	JJ
cord-297078-pxggjaby	287	19	sequence	sequence	NN
cord-297078-pxggjaby	287	20	is	be	VBZ
cord-297078-pxggjaby	287	21	produced	produce	VBN
cord-297078-pxggjaby	287	22	,	,	,
cord-297078-pxggjaby	287	23	the	the	DT
cord-297078-pxggjaby	287	24	tRNA	trna	NN
cord-297078-pxggjaby	287	25	can	can	MD
cord-297078-pxggjaby	287	26	be	be	VB
cord-297078-pxggjaby	287	27	aminoacylated	aminoacylate	VBN
cord-297078-pxggjaby	287	28	and	and	CC
cord-297078-pxggjaby	287	29	released	release	VBN
cord-297078-pxggjaby	287	30	from	from	IN
cord-297078-pxggjaby	287	31	the	the	DT
cord-297078-pxggjaby	287	32	cycle	cycle	NN
cord-297078-pxggjaby	287	33	of	of	IN
cord-297078-pxggjaby	287	34	degradation	degradation	NN
cord-297078-pxggjaby	287	35	and	and	CC
cord-297078-pxggjaby	287	36	elongation	elongation	NN
cord-297078-pxggjaby	287	37	(	(	-LRB-
cord-297078-pxggjaby	287	38	Reichert	Reichert	NNP
cord-297078-pxggjaby	287	39	and	and	CC
cord-297078-pxggjaby	287	40	Mörl	Mörl	NNP
cord-297078-pxggjaby	287	41	2000	2000	CD
cord-297078-pxggjaby	287	42	)	)	-RRB-
cord-297078-pxggjaby	287	43	.	.	.
cord-297078-pxggjaby	288	1	This	this	DT
cord-297078-pxggjaby	288	2	form	form	NN
cord-297078-pxggjaby	288	3	of	of	IN
cord-297078-pxggjaby	288	4	repair	repair	NN
cord-297078-pxggjaby	288	5	has	have	VBZ
cord-297078-pxggjaby	288	6	probably	probably	RB
cord-297078-pxggjaby	288	7	emerged	emerge	VBN
cord-297078-pxggjaby	288	8	to	to	TO
cord-297078-pxggjaby	288	9	tackle	tackle	VB
cord-297078-pxggjaby	288	10	the	the	DT
cord-297078-pxggjaby	288	11	peculiarities	peculiarity	NNS
cord-297078-pxggjaby	288	12	of	of	IN
cord-297078-pxggjaby	288	13	mammalian	mammalian	JJ
cord-297078-pxggjaby	288	14	mitochondrial	mitochondrial	JJ
cord-297078-pxggjaby	288	15	genomes	genome	NNS
cord-297078-pxggjaby	288	16	,	,	,
cord-297078-pxggjaby	288	17	where	where	WRB
cord-297078-pxggjaby	288	18	Muller	Muller	NNP
cord-297078-pxggjaby	288	19	's	's	POS
cord-297078-pxggjaby	288	20	ratchet	ratchet	NN
cord-297078-pxggjaby	288	21	is	be	VBZ
cord-297078-pxggjaby	288	22	operating	operate	VBG
cord-297078-pxggjaby	288	23	(	(	-LRB-
cord-297078-pxggjaby	288	24	Lynch	Lynch	NNP
cord-297078-pxggjaby	288	25	1996	1996	CD
cord-297078-pxggjaby	288	26	)	)	-RRB-
cord-297078-pxggjaby	288	27	.	.	.
cord-297078-pxggjaby	289	1	A	a	DT
cord-297078-pxggjaby	289	2	number	number	NN
cord-297078-pxggjaby	289	3	of	of	IN
cord-297078-pxggjaby	289	4	features	feature	NNS
cord-297078-pxggjaby	289	5	of	of	IN
cord-297078-pxggjaby	289	6	mitochondrial	mitochondrial	JJ
cord-297078-pxggjaby	289	7	genomes	genome	NNS
cord-297078-pxggjaby	289	8	are	be	VBP
cord-297078-pxggjaby	289	9	likely	likely	JJ
cord-297078-pxggjaby	289	10	to	to	TO
cord-297078-pxggjaby	289	11	be	be	VB
cord-297078-pxggjaby	289	12	attributable	attributable	JJ
cord-297078-pxggjaby	289	13	to	to	IN
cord-297078-pxggjaby	289	14	this	this	DT
cord-297078-pxggjaby	289	15	process	process	NN
cord-297078-pxggjaby	289	16	,	,	,
cord-297078-pxggjaby	289	17	notably	notably	RB
cord-297078-pxggjaby	289	18	RNA	RNA	NNP
cord-297078-pxggjaby	289	19	editing	editing	NN
cord-297078-pxggjaby	289	20	in	in	IN
cord-297078-pxggjaby	289	21	metazoan	metazoan	JJ
cord-297078-pxggjaby	289	22	mitochondria	mitochondrion	NNS
cord-297078-pxggjaby	290	1	(	(	-LRB-
cord-297078-pxggjaby	290	2	Börner	Börner	NNP
cord-297078-pxggjaby	290	3	et	et	NNP
cord-297078-pxggjaby	290	4	al	al	NNP
cord-297078-pxggjaby	290	5	.	.	.
cord-297078-pxggjaby	290	6	1997	1997	CD
cord-297078-pxggjaby	290	7	)	)	-RRB-
cord-297078-pxggjaby	290	8	.	.	.
cord-297078-pxggjaby	291	1	tRNA	tRNA	NNP
cord-297078-pxggjaby	291	2	repair	repair	NN
cord-297078-pxggjaby	291	3	is	be	VBZ
cord-297078-pxggjaby	291	4	therefore	therefore	RB
cord-297078-pxggjaby	291	5	best	well	RBS
cord-297078-pxggjaby	291	6	considered	consider	VBN
cord-297078-pxggjaby	291	7	a	a	DT
cord-297078-pxggjaby	291	8	form	form	NN
cord-297078-pxggjaby	291	9	of	of	IN
cord-297078-pxggjaby	291	10	organellar	organellar	NNP
cord-297078-pxggjaby	291	11	RNA	RNA	NNP
cord-297078-pxggjaby	291	12	editing	editing	NN
cord-297078-pxggjaby	291	13	.	.	.
cord-297078-pxggjaby	292	1	While	while	IN
cord-297078-pxggjaby	292	2	some	some	DT
cord-297078-pxggjaby	292	3	forms	form	NNS
cord-297078-pxggjaby	292	4	of	of	IN
cord-297078-pxggjaby	292	5	organellar	organellar	JJ
cord-297078-pxggjaby	292	6	editing	editing	NN
cord-297078-pxggjaby	292	7	are	be	VBP
cord-297078-pxggjaby	292	8	interesting	interesting	JJ
cord-297078-pxggjaby	292	9	for	for	IN
cord-297078-pxggjaby	292	10	the	the	DT
cord-297078-pxggjaby	292	11	RNA	RNA	NNP
cord-297078-pxggjaby	292	12	world	world	NN
cord-297078-pxggjaby	292	13	insofar	insofar	RB
cord-297078-pxggjaby	292	14	as	as	IN
cord-297078-pxggjaby	292	15	they	-PRON-	PRP
cord-297078-pxggjaby	292	16	illustrate	illustrate	VBP
cord-297078-pxggjaby	292	17	possible	possible	JJ
cord-297078-pxggjaby	292	18	RNA	rna	NN
cord-297078-pxggjaby	292	19	-	-	HYPH
cord-297078-pxggjaby	292	20	based	base	VBN
cord-297078-pxggjaby	292	21	processes	process	NNS
cord-297078-pxggjaby	292	22	,	,	,
cord-297078-pxggjaby	292	23	their	-PRON-	PRP$
cord-297078-pxggjaby	292	24	narrow	narrow	JJ
cord-297078-pxggjaby	292	25	phylogenetic	phylogenetic	JJ
cord-297078-pxggjaby	292	26	distribution	distribution	NN
cord-297078-pxggjaby	292	27	suggests	suggest	VBZ
cord-297078-pxggjaby	292	28	that	that	IN
cord-297078-pxggjaby	292	29	they	-PRON-	PRP
cord-297078-pxggjaby	292	30	are	be	VBP
cord-297078-pxggjaby	292	31	a	a	DT
cord-297078-pxggjaby	292	32	recent	recent	JJ
cord-297078-pxggjaby	292	33	phenomenon	phenomenon	NN
cord-297078-pxggjaby	292	34	.	.	.
cord-297078-pxggjaby	293	1	Recently	recently	RB
cord-297078-pxggjaby	293	2	,	,	,
cord-297078-pxggjaby	293	3	Aas	Aas	NNP
cord-297078-pxggjaby	293	4	et	et	NNP
cord-297078-pxggjaby	293	5	al	al	NNP
cord-297078-pxggjaby	293	6	.	.	.
cord-297078-pxggjaby	294	1	(	(	-LRB-
cord-297078-pxggjaby	294	2	2003	2003	CD
cord-297078-pxggjaby	294	3	)	)	-RRB-
cord-297078-pxggjaby	294	4	demonstrated	demonstrate	VBN
cord-297078-pxggjaby	294	5	in	in	IN
cord-297078-pxggjaby	294	6	vivo	vivo	NN
cord-297078-pxggjaby	294	7	repair	repair	NN
cord-297078-pxggjaby	294	8	of	of	IN
cord-297078-pxggjaby	294	9	aberrantly	aberrantly	RB
cord-297078-pxggjaby	294	10	methylated	methylate	VBN
cord-297078-pxggjaby	294	11	adenine	adenine	NN
cord-297078-pxggjaby	294	12	(	(	-LRB-
cord-297078-pxggjaby	294	13	1-methyladenine	1-methyladenine	CD
cord-297078-pxggjaby	294	14	)	)	-RRB-
cord-297078-pxggjaby	294	15	and	and	CC
cord-297078-pxggjaby	294	16	cytosine	cytosine	NN
cord-297078-pxggjaby	294	17	(	(	-LRB-
cord-297078-pxggjaby	294	18	3-methylcytosine	3-methylcytosine	CD
cord-297078-pxggjaby	294	19	)	)	-RRB-
cord-297078-pxggjaby	294	20	in	in	IN
cord-297078-pxggjaby	294	21	RNA	RNA	NNP
cord-297078-pxggjaby	294	22	by	by	IN
cord-297078-pxggjaby	294	23	oxidative	oxidative	JJ
cord-297078-pxggjaby	294	24	demethylases	demethylase	NNS
cord-297078-pxggjaby	294	25	.	.	.
cord-297078-pxggjaby	295	1	In	in	IN
cord-297078-pxggjaby	295	2	E.	E.	NNP
cord-297078-pxggjaby	295	3	coli	coli	NNS
cord-297078-pxggjaby	295	4	,	,	,
cord-297078-pxggjaby	295	5	AlkB	AlkB	NNP
cord-297078-pxggjaby	295	6	is	be	VBZ
cord-297078-pxggjaby	295	7	responsible	responsible	JJ
cord-297078-pxggjaby	295	8	for	for	IN
cord-297078-pxggjaby	295	9	repair	repair	NN
cord-297078-pxggjaby	295	10	of	of	IN
cord-297078-pxggjaby	295	11	these	these	DT
cord-297078-pxggjaby	295	12	lesions	lesion	NNS
cord-297078-pxggjaby	295	13	in	in	IN
cord-297078-pxggjaby	295	14	both	both	CC
cord-297078-pxggjaby	295	15	DNA	DNA	NNP
cord-297078-pxggjaby	295	16	and	and	CC
cord-297078-pxggjaby	295	17	RNA	RNA	NNP
cord-297078-pxggjaby	295	18	,	,	,
cord-297078-pxggjaby	295	19	while	while	IN
cord-297078-pxggjaby	295	20	in	in	IN
cord-297078-pxggjaby	295	21	human	human	NN
cord-297078-pxggjaby	295	22	,	,	,
cord-297078-pxggjaby	295	23	two	two	CD
cord-297078-pxggjaby	295	24	AlkB	AlkB	NNP
cord-297078-pxggjaby	295	25	homologues	homologue	NNS
cord-297078-pxggjaby	295	26	provide	provide	VBP
cord-297078-pxggjaby	295	27	a	a	DT
cord-297078-pxggjaby	295	28	division	division	NN
cord-297078-pxggjaby	295	29	of	of	IN
cord-297078-pxggjaby	295	30	labor	labor	NN
cord-297078-pxggjaby	295	31	;	;	:
cord-297078-pxggjaby	295	32	hABH2	habh2	ADD
cord-297078-pxggjaby	295	33	has	have	VBZ
cord-297078-pxggjaby	295	34	a	a	DT
cord-297078-pxggjaby	295	35	preference	preference	NN
cord-297078-pxggjaby	295	36	for	for	IN
cord-297078-pxggjaby	295	37	double	double	RB
cord-297078-pxggjaby	295	38	-	-	HYPH
cord-297078-pxggjaby	295	39	stranded	strand	VBN
cord-297078-pxggjaby	295	40	DNA	dna	NN
cord-297078-pxggjaby	295	41	,	,	,
cord-297078-pxggjaby	295	42	repairing	repair	VBG
cord-297078-pxggjaby	295	43	lesions	lesion	NNS
cord-297078-pxggjaby	295	44	close	close	JJ
cord-297078-pxggjaby	295	45	to	to	IN
cord-297078-pxggjaby	295	46	the	the	DT
cord-297078-pxggjaby	295	47	replication	replication	NN
cord-297078-pxggjaby	295	48	fork	fork	NN
cord-297078-pxggjaby	295	49	,	,	,
cord-297078-pxggjaby	295	50	while	while	IN
cord-297078-pxggjaby	295	51	hABH3	habh3	NN
cord-297078-pxggjaby	295	52	has	have	VBZ
cord-297078-pxggjaby	295	53	a	a	DT
cord-297078-pxggjaby	295	54	preference	preference	NN
cord-297078-pxggjaby	295	55	for	for	IN
cord-297078-pxggjaby	295	56	singlestranded	singlestranded	JJ
cord-297078-pxggjaby	295	57	substrates	substrate	NNS
cord-297078-pxggjaby	295	58	(	(	-LRB-
cord-297078-pxggjaby	295	59	both	both	DT
cord-297078-pxggjaby	295	60	single	single	RB
cord-297078-pxggjaby	295	61	-	-	HYPH
cord-297078-pxggjaby	295	62	stranded	strand	VBN
cord-297078-pxggjaby	295	63	DNA	DNA	NNP
cord-297078-pxggjaby	295	64	and	and	CC
cord-297078-pxggjaby	295	65	RNA	RNA	NNP
cord-297078-pxggjaby	295	66	)	)	-RRB-
cord-297078-pxggjaby	295	67	,	,	,
cord-297078-pxggjaby	295	68	suggesting	suggest	VBG
cord-297078-pxggjaby	295	69	that	that	IN
cord-297078-pxggjaby	295	70	it	-PRON-	PRP
cord-297078-pxggjaby	295	71	operates	operate	VBZ
cord-297078-pxggjaby	295	72	during	during	IN
cord-297078-pxggjaby	295	73	transcription	transcription	NN
cord-297078-pxggjaby	295	74	.	.	.
cord-297078-pxggjaby	296	1	More	more	RBR
cord-297078-pxggjaby	296	2	recently	recently	RB
cord-297078-pxggjaby	296	3	,	,	,
cord-297078-pxggjaby	296	4	it	-PRON-	PRP
cord-297078-pxggjaby	296	5	has	have	VBZ
cord-297078-pxggjaby	296	6	been	be	VBN
cord-297078-pxggjaby	296	7	demonstrated	demonstrate	VBN
cord-297078-pxggjaby	296	8	that	that	IN
cord-297078-pxggjaby	296	9	both	both	DT
cord-297078-pxggjaby	296	10	E.	E.	NNP
cord-297078-pxggjaby	296	11	coli	coli	VBZ
cord-297078-pxggjaby	296	12	AlkB	AlkB	NNP
cord-297078-pxggjaby	296	13	and	and	CC
cord-297078-pxggjaby	296	14	hABH3	habh3	NN
cord-297078-pxggjaby	296	15	repair	repair	VB
cord-297078-pxggjaby	296	16	both	both	CC
cord-297078-pxggjaby	296	17	mRNA	mRNA	NNP
cord-297078-pxggjaby	296	18	and	and	CC
cord-297078-pxggjaby	296	19	tRNA	trna	NN
cord-297078-pxggjaby	296	20	damaged	damage	VBN
cord-297078-pxggjaby	296	21	by	by	IN
cord-297078-pxggjaby	296	22	methylation	methylation	NN
cord-297078-pxggjaby	296	23	(	(	-LRB-
cord-297078-pxggjaby	296	24	Ougland	Ougland	NNP
cord-297078-pxggjaby	296	25	et	et	NNP
cord-297078-pxggjaby	296	26	al	al	NNP
cord-297078-pxggjaby	296	27	.	.	.
cord-297078-pxggjaby	296	28	2004	2004	CD
cord-297078-pxggjaby	296	29	)	)	-RRB-
cord-297078-pxggjaby	296	30	.	.	.
cord-297078-pxggjaby	297	1	The	the	DT
cord-297078-pxggjaby	297	2	initial	initial	JJ
cord-297078-pxggjaby	297	3	lead	lead	NN
cord-297078-pxggjaby	297	4	that	that	WDT
cord-297078-pxggjaby	297	5	suggested	suggest	VBD
cord-297078-pxggjaby	297	6	a	a	DT
cord-297078-pxggjaby	297	7	role	role	NN
cord-297078-pxggjaby	297	8	for	for	IN
cord-297078-pxggjaby	297	9	AlkB	AlkB	NNP
cord-297078-pxggjaby	297	10	in	in	IN
cord-297078-pxggjaby	297	11	RNA	RNA	NNP
cord-297078-pxggjaby	297	12	repair	repair	NN
cord-297078-pxggjaby	297	13	came	come	VBD
cord-297078-pxggjaby	297	14	via	via	IN
cord-297078-pxggjaby	297	15	a	a	DT
cord-297078-pxggjaby	297	16	BLAST	blast	NN
cord-297078-pxggjaby	297	17	survey	survey	NN
cord-297078-pxggjaby	297	18	for	for	IN
cord-297078-pxggjaby	297	19	proteins	protein	NNS
cord-297078-pxggjaby	297	20	with	with	IN
cord-297078-pxggjaby	297	21	a	a	DT
cord-297078-pxggjaby	297	22	2-oxoglutarate	2-oxoglutarate	CD
cord-297078-pxggjaby	297	23	-	-	HYPH
cord-297078-pxggjaby	297	24	Fe(II	fe(ii	NN
cord-297078-pxggjaby	297	25	)	)	-RRB-
cord-297078-pxggjaby	297	26	oxygenase	oxygenase	NN
cord-297078-pxggjaby	297	27	fold	fold	NN
cord-297078-pxggjaby	297	28	(	(	-LRB-
cord-297078-pxggjaby	297	29	Aravind	Aravind	NNP
cord-297078-pxggjaby	297	30	and	and	CC
cord-297078-pxggjaby	297	31	Koonin	Koonin	NNP
cord-297078-pxggjaby	297	32	2001	2001	CD
cord-297078-pxggjaby	297	33	)	)	-RRB-
cord-297078-pxggjaby	297	34	.	.	.
cord-297078-pxggjaby	298	1	Homologues	Homologues	NNP
cord-297078-pxggjaby	298	2	of	of	IN
cord-297078-pxggjaby	298	3	AlkB	AlkB	NNP
cord-297078-pxggjaby	298	4	from	from	IN
cord-297078-pxggjaby	298	5	seven	seven	CD
cord-297078-pxggjaby	298	6	plant	plant	NN
cord-297078-pxggjaby	298	7	RNA	RNA	NNP
cord-297078-pxggjaby	298	8	viruses	virus	NNS
cord-297078-pxggjaby	298	9	were	be	VBD
cord-297078-pxggjaby	298	10	identified	identify	VBN
cord-297078-pxggjaby	298	11	,	,	,
cord-297078-pxggjaby	298	12	suggesting	suggest	VBG
cord-297078-pxggjaby	298	13	a	a	DT
cord-297078-pxggjaby	298	14	role	role	NN
cord-297078-pxggjaby	298	15	in	in	IN
cord-297078-pxggjaby	298	16	RNA	RNA	NNP
cord-297078-pxggjaby	298	17	demethylation	demethylation	NN
cord-297078-pxggjaby	298	18	,	,	,
cord-297078-pxggjaby	298	19	perhaps	perhaps	RB
cord-297078-pxggjaby	298	20	in	in	IN
cord-297078-pxggjaby	298	21	countering	counter	VBG
cord-297078-pxggjaby	298	22	a	a	DT
cord-297078-pxggjaby	298	23	host	host	NN
cord-297078-pxggjaby	298	24	-	-	HYPH
cord-297078-pxggjaby	298	25	defence	defence	NN
cord-297078-pxggjaby	298	26	strategy	strategy	NN
cord-297078-pxggjaby	298	27	involving	involve	VBG
cord-297078-pxggjaby	298	28	viral	viral	JJ
cord-297078-pxggjaby	298	29	RNA	RNA	NNP
cord-297078-pxggjaby	298	30	methylation	methylation	NN
cord-297078-pxggjaby	298	31	.	.	.
cord-297078-pxggjaby	299	1	The	the	DT
cord-297078-pxggjaby	299	2	demonstration	demonstration	NN
cord-297078-pxggjaby	299	3	that	that	WDT
cord-297078-pxggjaby	299	4	AlkB	AlkB	NNP
cord-297078-pxggjaby	299	5	-	-	HYPH
cord-297078-pxggjaby	299	6	family	family	NN
cord-297078-pxggjaby	299	7	proteins	protein	NNS
cord-297078-pxggjaby	299	8	can	can	MD
cord-297078-pxggjaby	299	9	repair	repair	VB
cord-297078-pxggjaby	299	10	RNA	RNA	NNP
cord-297078-pxggjaby	299	11	suggests	suggest	VBZ
cord-297078-pxggjaby	299	12	that	that	IN
cord-297078-pxggjaby	299	13	these	these	DT
cord-297078-pxggjaby	299	14	RNA	RNA	NNP
cord-297078-pxggjaby	299	15	virus	virus	NN
cord-297078-pxggjaby	299	16	homologues	homologue	NNS
cord-297078-pxggjaby	299	17	are	be	VBP
cord-297078-pxggjaby	299	18	involved	involve	VBN
cord-297078-pxggjaby	299	19	in	in	IN
cord-297078-pxggjaby	299	20	genome	genome	NN
cord-297078-pxggjaby	299	21	maintenance	maintenance	NN
cord-297078-pxggjaby	299	22	.	.	.
cord-297078-pxggjaby	300	1	Oxidative	oxidative	JJ
cord-297078-pxggjaby	300	2	demethylation	demethylation	NN
cord-297078-pxggjaby	300	3	is	be	VBZ
cord-297078-pxggjaby	300	4	not	not	RB
cord-297078-pxggjaby	300	5	universal	universal	JJ
cord-297078-pxggjaby	300	6	in	in	IN
cord-297078-pxggjaby	300	7	distribution	distribution	NN
cord-297078-pxggjaby	300	8	(	(	-LRB-
cord-297078-pxggjaby	300	9	no	no	DT
cord-297078-pxggjaby	300	10	archaeal	archaeal	JJ
cord-297078-pxggjaby	300	11	AlkB	AlkB	NNP
cord-297078-pxggjaby	300	12	homologues	homologue	NNS
cord-297078-pxggjaby	300	13	have	have	VBP
cord-297078-pxggjaby	300	14	been	be	VBN
cord-297078-pxggjaby	300	15	detected	detect	VBN
cord-297078-pxggjaby	300	16	)	)	-RRB-
cord-297078-pxggjaby	300	17	,	,	,
cord-297078-pxggjaby	300	18	and	and	CC
cord-297078-pxggjaby	300	19	it	-PRON-	PRP
cord-297078-pxggjaby	300	20	is	be	VBZ
cord-297078-pxggjaby	300	21	difficult	difficult	JJ
cord-297078-pxggjaby	300	22	to	to	TO
cord-297078-pxggjaby	300	23	establish	establish	VB
cord-297078-pxggjaby	300	24	the	the	DT
cord-297078-pxggjaby	300	25	antiquity	antiquity	NN
cord-297078-pxggjaby	300	26	of	of	IN
cord-297078-pxggjaby	300	27	this	this	DT
cord-297078-pxggjaby	300	28	process	process	NN
cord-297078-pxggjaby	300	29	.	.	.
cord-297078-pxggjaby	301	1	Aravind	Aravind	NNP
cord-297078-pxggjaby	301	2	and	and	CC
cord-297078-pxggjaby	301	3	Koonin	Koonin	NNP
cord-297078-pxggjaby	301	4	(	(	-LRB-
cord-297078-pxggjaby	301	5	2001	2001	CD
cord-297078-pxggjaby	301	6	)	)	-RRB-
cord-297078-pxggjaby	301	7	report	report	VBP
cord-297078-pxggjaby	301	8	that	that	IN
cord-297078-pxggjaby	301	9	the	the	DT
cord-297078-pxggjaby	301	10	2-oxoglutarate	2-oxoglutarate	CD
cord-297078-pxggjaby	301	11	-	-	HYPH
cord-297078-pxggjaby	301	12	Fe(II	fe(ii	NN
cord-297078-pxggjaby	301	13	)	)	-RRB-
cord-297078-pxggjaby	302	1	oxygenase	oxygenase	NNP
cord-297078-pxggjaby	302	2	superfamily	superfamily	NN
cord-297078-pxggjaby	302	3	possesses	possess	VBZ
cord-297078-pxggjaby	302	4	a	a	DT
cord-297078-pxggjaby	302	5	universally	universally	RB
cord-297078-pxggjaby	302	6	conserved	conserve	VBN
cord-297078-pxggjaby	302	7	protein	protein	NN
cord-297078-pxggjaby	302	8	fold	fold	NN
cord-297078-pxggjaby	302	9	(	(	-LRB-
cord-297078-pxggjaby	302	10	the	the	DT
cord-297078-pxggjaby	302	11	DSBH	dsbh	NN
cord-297078-pxggjaby	302	12	fold	fold	NN
cord-297078-pxggjaby	302	13	)	)	-RRB-
cord-297078-pxggjaby	302	14	but	but	CC
cord-297078-pxggjaby	302	15	have	have	VBP
cord-297078-pxggjaby	302	16	invoked	invoke	VBN
cord-297078-pxggjaby	302	17	horizontal	horizontal	JJ
cord-297078-pxggjaby	302	18	gene	gene	NN
cord-297078-pxggjaby	302	19	transfer	transfer	NN
cord-297078-pxggjaby	302	20	to	to	TO
cord-297078-pxggjaby	302	21	explain	explain	VB
cord-297078-pxggjaby	302	22	the	the	DT
cord-297078-pxggjaby	302	23	origin	origin	NN
cord-297078-pxggjaby	302	24	of	of	IN
cord-297078-pxggjaby	302	25	the	the	DT
cord-297078-pxggjaby	302	26	eukaryote	eukaryote	NN
cord-297078-pxggjaby	302	27	AlkB	AlkB	NNP
cord-297078-pxggjaby	302	28	homologues	homologue	NNS
cord-297078-pxggjaby	302	29	,	,	,
cord-297078-pxggjaby	302	30	though	though	IN
cord-297078-pxggjaby	302	31	no	no	DT
cord-297078-pxggjaby	302	32	phylogenetic	phylogenetic	JJ
cord-297078-pxggjaby	302	33	evidence	evidence	NN
cord-297078-pxggjaby	302	34	was	be	VBD
cord-297078-pxggjaby	302	35	presented	present	VBN
cord-297078-pxggjaby	302	36	to	to	TO
cord-297078-pxggjaby	302	37	support	support	VB
cord-297078-pxggjaby	302	38	their	-PRON-	PRP$
cord-297078-pxggjaby	302	39	claim	claim	NN
cord-297078-pxggjaby	302	40	(	(	-LRB-
cord-297078-pxggjaby	302	41	Aravind	Aravind	NNP
cord-297078-pxggjaby	302	42	and	and	CC
cord-297078-pxggjaby	302	43	Koonin	Koonin	NNP
cord-297078-pxggjaby	302	44	2001	2001	CD
cord-297078-pxggjaby	302	45	)	)	-RRB-
cord-297078-pxggjaby	302	46	.	.	.
cord-297078-pxggjaby	302	47	 	 	_SP
cord-297078-pxggjaby	303	1	Structural	structural	JJ
cord-297078-pxggjaby	303	2	insights	insight	NNS
cord-297078-pxggjaby	303	3	into	into	IN
cord-297078-pxggjaby	303	4	the	the	DT
cord-297078-pxggjaby	303	5	origins	origin	NNS
cord-297078-pxggjaby	303	6	of	of	IN
cord-297078-pxggjaby	303	7	DNA	dna	NN
cord-297078-pxggjaby	303	8	polymerase	polymerase	NN
cord-297078-pxggjaby	303	9	fidelity	fidelity	NN
cord-297078-pxggjaby	303	10	Modern	modern	JJ
cord-297078-pxggjaby	303	11	metabolism	metabolism	NN
cord-297078-pxggjaby	303	12	as	as	IN
cord-297078-pxggjaby	303	13	a	a	DT
cord-297078-pxggjaby	303	14	palimpsest	palimpsest	NN
cord-297078-pxggjaby	303	15	of	of	IN
cord-297078-pxggjaby	303	16	the	the	DT
cord-297078-pxggjaby	303	17	RNA	RNA	NNP
cord-297078-pxggjaby	303	18	world	world	NN
cord-297078-pxggjaby	304	1	An	an	DT
cord-297078-pxggjaby	304	2	RNA	RNA	NNP
cord-297078-pxggjaby	304	3	that	that	WDT
cord-297078-pxggjaby	304	4	multiplies	multiply	VBZ
cord-297078-pxggjaby	304	5	indefinitely	indefinitely	RB
cord-297078-pxggjaby	304	6	with	with	IN
cord-297078-pxggjaby	304	7	DNA	dna	NN
cord-297078-pxggjaby	304	8	-	-	HYPH
cord-297078-pxggjaby	304	9	dependent	dependent	JJ
cord-297078-pxggjaby	304	10	RNA	RNA	NNP
cord-297078-pxggjaby	304	11	polymerase	polymerase	NN
cord-297078-pxggjaby	305	1	:	:	:
cord-297078-pxggjaby	305	2	selection	selection	NN
cord-297078-pxggjaby	305	3	from	from	IN
cord-297078-pxggjaby	305	4	a	a	DT
cord-297078-pxggjaby	305	5	random	random	JJ
cord-297078-pxggjaby	305	6	copolymer	copolymer	NN
cord-297078-pxggjaby	305	7	co	co	NNS
cord-297078-pxggjaby	305	8	-	-	NNS
cord-297078-pxggjaby	305	9	authors	author	NNS
cord-297078-pxggjaby	305	10	)	)	-RRB-
cord-297078-pxggjaby	305	11	.	.	.
cord-297078-pxggjaby	306	1	1997	1997	CD
cord-297078-pxggjaby	306	2	.	.	.
cord-297078-pxggjaby	307	1	The	the	DT
cord-297078-pxggjaby	307	2	complete	complete	JJ
cord-297078-pxggjaby	307	3	genome	genome	NN
cord-297078-pxggjaby	307	4	sequence	sequence	NN
cord-297078-pxggjaby	307	5	of	of	IN
cord-297078-pxggjaby	307	6	Escherichia	Escherichia	NNP
cord-297078-pxggjaby	307	7	coli	coli	VBZ
cord-297078-pxggjaby	307	8	K-12	K-12	NNP
cord-297078-pxggjaby	307	9	RNA	RNA	NNP
cord-297078-pxggjaby	307	10	editing	editing	NN
cord-297078-pxggjaby	307	11	in	in	IN
cord-297078-pxggjaby	307	12	metazoan	metazoan	JJ
cord-297078-pxggjaby	307	13	mitochondria	mitochondrion	NNS
cord-297078-pxggjaby	307	14	:	:	:
cord-297078-pxggjaby	307	15	staying	stay	VBG
cord-297078-pxggjaby	307	16	fit	fit	JJ
cord-297078-pxggjaby	307	17	without	without	IN
cord-297078-pxggjaby	307	18	sex	sex	NN
cord-297078-pxggjaby	308	1	The	the	DT
cord-297078-pxggjaby	308	2	RNA	RNA	NNP
cord-297078-pxggjaby	308	3	cleavage	cleavage	NN
cord-297078-pxggjaby	308	4	activity	activity	NN
cord-297078-pxggjaby	308	5	of	of	IN
cord-297078-pxggjaby	308	6	RNA	RNA	NNP
cord-297078-pxggjaby	308	7	polymerase	polymerase	NN
cord-297078-pxggjaby	308	8	III	III	NNP
cord-297078-pxggjaby	308	9	is	be	VBZ
cord-297078-pxggjaby	308	10	mediated	mediate	VBN
cord-297078-pxggjaby	308	11	by	by	IN
cord-297078-pxggjaby	308	12	an	an	DT
cord-297078-pxggjaby	308	13	essential	essential	JJ
cord-297078-pxggjaby	308	14	TFIIS	TFIIS	NNP
cord-297078-pxggjaby	308	15	-	-	HYPH
cord-297078-pxggjaby	308	16	like	like	JJ
cord-297078-pxggjaby	308	17	subunit	subunit	NN
cord-297078-pxggjaby	308	18	and	and	CC
cord-297078-pxggjaby	308	19	is	be	VBZ
cord-297078-pxggjaby	308	20	important	important	JJ
cord-297078-pxggjaby	308	21	for	for	IN
cord-297078-pxggjaby	308	22	transcription	transcription	NN
cord-297078-pxggjaby	308	23	termination	termination	NN
cord-297078-pxggjaby	308	24	Common	common	JJ
cord-297078-pxggjaby	308	25	structural	structural	JJ
cord-297078-pxggjaby	308	26	features	feature	NNS
cord-297078-pxggjaby	308	27	of	of	IN
cord-297078-pxggjaby	308	28	nucleic	nucleic	JJ
cord-297078-pxggjaby	308	29	acid	acid	NN
cord-297078-pxggjaby	308	30	polymerases	polymerase	NNS
cord-297078-pxggjaby	308	31	The	the	DT
cord-297078-pxggjaby	308	32	origin	origin	NN
cord-297078-pxggjaby	308	33	of	of	IN
cord-297078-pxggjaby	308	34	the	the	DT
cord-297078-pxggjaby	308	35	genetic	genetic	JJ
cord-297078-pxggjaby	308	36	code	code	NN
cord-297078-pxggjaby	308	37	Implications	implication	NNS
cord-297078-pxggjaby	308	38	of	of	IN
cord-297078-pxggjaby	308	39	high	high	JJ
cord-297078-pxggjaby	308	40	RNA	RNA	NNP
cord-297078-pxggjaby	308	41	virus	virus	NN
cord-297078-pxggjaby	308	42	mutation	mutation	NN
cord-297078-pxggjaby	308	43	rates	rate	NNS
cord-297078-pxggjaby	308	44	:	:	:
cord-297078-pxggjaby	308	45	lethal	lethal	JJ
cord-297078-pxggjaby	308	46	mutagenesis	mutagenesis	NN
cord-297078-pxggjaby	308	47	and	and	CC
cord-297078-pxggjaby	308	48	the	the	DT
cord-297078-pxggjaby	308	49	antiviral	antiviral	JJ
cord-297078-pxggjaby	308	50	drug	drug	NN
cord-297078-pxggjaby	308	51	ribavirin	ribavirin	NN
cord-297078-pxggjaby	308	52	Potato	Potato	NNP
cord-297078-pxggjaby	308	53	spindle	spindle	NN
cord-297078-pxggjaby	308	54	tuber	tuber	NN
cord-297078-pxggjaby	308	55	'	'	''
cord-297078-pxggjaby	308	56	'	'	''
cord-297078-pxggjaby	308	57	virus	virus	NN
cord-297078-pxggjaby	308	58	.	.	.
cord-297078-pxggjaby	308	59	'	'	''
cord-297078-pxggjaby	308	60	'	'	''
cord-297078-pxggjaby	309	1	IV	IV	NNP
cord-297078-pxggjaby	309	2	.	.	.
cord-297078-pxggjaby	310	1	A	a	DT
cord-297078-pxggjaby	310	2	replicating	replicate	VBG
cord-297078-pxggjaby	310	3	,	,	,
cord-297078-pxggjaby	310	4	low	low	JJ
cord-297078-pxggjaby	310	5	molecular	molecular	JJ
cord-297078-pxggjaby	310	6	weight	weight	NN
cord-297078-pxggjaby	310	7	RNA	RNA	NNP
cord-297078-pxggjaby	311	1	The	the	DT
cord-297078-pxggjaby	311	2	roads	road	NNS
cord-297078-pxggjaby	311	3	to	to	IN
cord-297078-pxggjaby	311	4	and	and	CC
cord-297078-pxggjaby	311	5	from	from	IN
cord-297078-pxggjaby	311	6	the	the	DT
cord-297078-pxggjaby	311	7	RNA	RNA	NNP
cord-297078-pxggjaby	311	8	world	world	NN
cord-297078-pxggjaby	311	9	Multiple	Multiple	NNP
cord-297078-pxggjaby	311	10	RNA	RNA	NNP
cord-297078-pxggjaby	311	11	polymerase	polymerase	NN
cord-297078-pxggjaby	311	12	conformations	conformation	NNS
cord-297078-pxggjaby	311	13	and	and	CC
cord-297078-pxggjaby	311	14	GreA	GreA	NNP
cord-297078-pxggjaby	311	15	:	:	:
cord-297078-pxggjaby	311	16	control	control	NN
cord-297078-pxggjaby	311	17	of	of	IN
cord-297078-pxggjaby	311	18	the	the	DT
cord-297078-pxggjaby	311	19	fidelity	fidelity	NN
cord-297078-pxggjaby	311	20	of	of	IN
cord-297078-pxggjaby	311	21	transcription	transcription	NN
cord-297078-pxggjaby	311	22	A	a	DT
cord-297078-pxggjaby	311	23	genome	genome	NN
cord-297078-pxggjaby	311	24	phylogeny	phylogeny	NN
cord-297078-pxggjaby	311	25	for	for	IN
cord-297078-pxggjaby	311	26	mitochondria	mitochondrion	NNS
cord-297078-pxggjaby	311	27	among	among	IN
cord-297078-pxggjaby	311	28	alphaproteobacteria	alphaproteobacteria	NNS
cord-297078-pxggjaby	311	29	and	and	CC
cord-297078-pxggjaby	311	30	a	a	DT
cord-297078-pxggjaby	311	31	predominantly	predominantly	RB
cord-297078-pxggjaby	311	32	eubacterial	eubacterial	JJ
cord-297078-pxggjaby	311	33	ancestry	ancestry	NN
cord-297078-pxggjaby	311	34	of	of	IN
cord-297078-pxggjaby	311	35	yeast	yeast	NN
cord-297078-pxggjaby	311	36	nuclear	nuclear	JJ
cord-297078-pxggjaby	311	37	genes	gene	NNS
cord-297078-pxggjaby	311	38	Transcription	Transcription	NNP
cord-297078-pxggjaby	311	39	of	of	IN
cord-297078-pxggjaby	311	40	potato	potato	NN
cord-297078-pxggjaby	311	41	spindle	spindle	NN
cord-297078-pxggjaby	311	42	tuber	tuber	NN
cord-297078-pxggjaby	312	1	viroid	viroid	NNP
cord-297078-pxggjaby	312	2	by	by	IN
cord-297078-pxggjaby	312	3	RNA	RNA	NNP
cord-297078-pxggjaby	312	4	polymerase	polymerase	NN
cord-297078-pxggjaby	312	5	II	II	NNP
cord-297078-pxggjaby	312	6	starts	start	VBZ
cord-297078-pxggjaby	312	7	predominantly	predominantly	RB
cord-297078-pxggjaby	312	8	at	at	IN
cord-297078-pxggjaby	312	9	two	two	CD
cord-297078-pxggjaby	312	10	specific	specific	JJ
cord-297078-pxggjaby	312	11	sites	site	NNS
cord-297078-pxggjaby	312	12	Mutants	mutant	NNS
cord-297078-pxggjaby	312	13	of	of	IN
cord-297078-pxggjaby	312	14	Escherichia	Escherichia	NNP
cord-297078-pxggjaby	312	15	coli	coli	NNS
cord-297078-pxggjaby	312	16	with	with	IN
cord-297078-pxggjaby	312	17	increased	increase	VBN
cord-297078-pxggjaby	312	18	fidelity	fidelity	NN
cord-297078-pxggjaby	312	19	of	of	IN
cord-297078-pxggjaby	312	20	DNA	dna	NN
cord-297078-pxggjaby	312	21	replication	replication	NN
cord-297078-pxggjaby	312	22	Evolution	evolution	NN
cord-297078-pxggjaby	312	23	of	of	IN
cord-297078-pxggjaby	312	24	DNA	dna	NN
cord-297078-pxggjaby	312	25	polymerase	polymerase	NN
cord-297078-pxggjaby	312	26	families	family	NNS
cord-297078-pxggjaby	312	27	:	:	:
cord-297078-pxggjaby	312	28	evidences	evidence	NNS
cord-297078-pxggjaby	312	29	for	for	IN
cord-297078-pxggjaby	312	30	multiple	multiple	JJ
cord-297078-pxggjaby	312	31	gene	gene	NN
cord-297078-pxggjaby	312	32	exchange	exchange	NN
cord-297078-pxggjaby	312	33	between	between	IN
cord-297078-pxggjaby	312	34	cellular	cellular	JJ
cord-297078-pxggjaby	312	35	and	and	CC
cord-297078-pxggjaby	312	36	viral	viral	JJ
cord-297078-pxggjaby	312	37	proteins	protein	NNS
cord-297078-pxggjaby	312	38	Promoting	promote	VBG
cord-297078-pxggjaby	312	39	elongation	elongation	NN
cord-297078-pxggjaby	312	40	with	with	IN
cord-297078-pxggjaby	312	41	transcript	transcript	NN
cord-297078-pxggjaby	312	42	cleavage	cleavage	NN
cord-297078-pxggjaby	312	43	stimulatory	stimulatory	JJ
cord-297078-pxggjaby	312	44	factors	factor	NNS
cord-297078-pxggjaby	313	1	Viroids	Viroids	NNP
cord-297078-pxggjaby	313	2	:	:	:
cord-297078-pxggjaby	314	1	the	the	DT
cord-297078-pxggjaby	314	2	minimal	minimal	JJ
cord-297078-pxggjaby	314	3	non	non	JJ
cord-297078-pxggjaby	314	4	-	-	JJ
cord-297078-pxggjaby	314	5	coding	coding	JJ
cord-297078-pxggjaby	314	6	RNAs	rna	NNS
cord-297078-pxggjaby	314	7	with	with	IN
cord-297078-pxggjaby	314	8	autonomous	autonomous	JJ
cord-297078-pxggjaby	314	9	replication	replication	NN
cord-297078-pxggjaby	314	10	Displacement	displacement	NN
cord-297078-pxggjaby	314	11	of	of	IN
cord-297078-pxggjaby	314	12	cellular	cellular	JJ
cord-297078-pxggjaby	314	13	proteins	protein	NNS
cord-297078-pxggjaby	314	14	by	by	IN
cord-297078-pxggjaby	314	15	functional	functional	JJ
cord-297078-pxggjaby	314	16	analogues	analogue	NNS
cord-297078-pxggjaby	314	17	from	from	IN
cord-297078-pxggjaby	314	18	plasmids	plasmid	NNS
cord-297078-pxggjaby	314	19	or	or	CC
cord-297078-pxggjaby	314	20	viruses	virus	NNS
cord-297078-pxggjaby	314	21	could	could	MD
cord-297078-pxggjaby	314	22	explain	explain	VB
cord-297078-pxggjaby	314	23	puzzling	puzzle	VBG
cord-297078-pxggjaby	314	24	phylogenies	phylogeny	NNS
cord-297078-pxggjaby	314	25	of	of	IN
cord-297078-pxggjaby	314	26	many	many	JJ
cord-297078-pxggjaby	314	27	DNA	dna	NN
cord-297078-pxggjaby	314	28	informational	informational	JJ
cord-297078-pxggjaby	314	29	proteins	protein	NNS
cord-297078-pxggjaby	314	30	Genomics	genomic	NNS
cord-297078-pxggjaby	314	31	and	and	CC
cord-297078-pxggjaby	314	32	early	early	JJ
cord-297078-pxggjaby	314	33	cellular	cellular	JJ
cord-297078-pxggjaby	314	34	evolution	evolution	NN
cord-297078-pxggjaby	314	35	.	.	.
cord-297078-pxggjaby	315	1	The	the	DT
cord-297078-pxggjaby	315	2	origin	origin	NN
cord-297078-pxggjaby	315	3	of	of	IN
cord-297078-pxggjaby	315	4	the	the	DT
cord-297078-pxggjaby	315	5	DNA	dna	NN
cord-297078-pxggjaby	315	6	world	world	NN
cord-297078-pxggjaby	315	7	Origin	origin	NN
cord-297078-pxggjaby	315	8	and	and	CC
cord-297078-pxggjaby	315	9	evolution	evolution	NN
cord-297078-pxggjaby	315	10	of	of	IN
cord-297078-pxggjaby	315	11	DNA	dna	NN
cord-297078-pxggjaby	315	12	and	and	CC
cord-297078-pxggjaby	315	13	DNA	dna	NN
cord-297078-pxggjaby	315	14	replication	replication	NN
cord-297078-pxggjaby	315	15	machineries	machinery	NNS
cord-297078-pxggjaby	316	1	The	the	DT
cord-297078-pxggjaby	316	2	role	role	NN
cord-297078-pxggjaby	316	3	of	of	IN
cord-297078-pxggjaby	316	4	the	the	DT
cord-297078-pxggjaby	316	5	nucleic	nucleic	JJ
cord-297078-pxggjaby	316	6	acid	acid	NN
cord-297078-pxggjaby	316	7	in	in	IN
cord-297078-pxggjaby	316	8	the	the	DT
cord-297078-pxggjaby	316	9	reconstitution	reconstitution	NN
cord-297078-pxggjaby	316	10	of	of	IN
cord-297078-pxggjaby	316	11	active	active	JJ
cord-297078-pxggjaby	316	12	Tobacco	Tobacco	NNP
cord-297078-pxggjaby	316	13	Mosaic	Mosaic	NNP
cord-297078-pxggjaby	316	14	Virus	Virus	NNP
cord-297078-pxggjaby	316	15	Conferring	Conferring	NNP
cord-297078-pxggjaby	316	16	RNA	RNA	NNP
cord-297078-pxggjaby	316	17	polymerase	polymerase	NN
cord-297078-pxggjaby	316	18	activity	activity	NN
cord-297078-pxggjaby	316	19	to	to	IN
cord-297078-pxggjaby	316	20	a	a	DT
cord-297078-pxggjaby	316	21	DNA	dna	NN
cord-297078-pxggjaby	316	22	polymerase	polymerase	NN
cord-297078-pxggjaby	316	23	:	:	:
cord-297078-pxggjaby	316	24	a	a	DT
cord-297078-pxggjaby	316	25	single	single	JJ
cord-297078-pxggjaby	316	26	residue	residue	NN
cord-297078-pxggjaby	316	27	in	in	IN
cord-297078-pxggjaby	316	28	reverse	reverse	JJ
cord-297078-pxggjaby	316	29	transcriptase	transcriptase	NN
cord-297078-pxggjaby	316	30	controls	control	NNS
cord-297078-pxggjaby	316	31	substrate	substrate	NN
cord-297078-pxggjaby	316	32	selection	selection	NN
cord-297078-pxggjaby	316	33	Infectivity	infectivity	NN
cord-297078-pxggjaby	316	34	of	of	IN
cord-297078-pxggjaby	316	35	ribonucleic	ribonucleic	NN
cord-297078-pxggjaby	316	36	acid	acid	NN
cord-297078-pxggjaby	316	37	from	from	IN
cord-297078-pxggjaby	316	38	Tobacco	Tobacco	NNP
cord-297078-pxggjaby	316	39	Mosaic	Mosaic	NNP
cord-297078-pxggjaby	316	40	Virus	Virus	NNP
cord-297078-pxggjaby	317	1	The	the	DT
cord-297078-pxggjaby	317	2	RNA	RNA	NNP
cord-297078-pxggjaby	317	3	world	world	NN
cord-297078-pxggjaby	317	4	Emerging	emerge	VBG
cord-297078-pxggjaby	317	5	views	view	NNS
cord-297078-pxggjaby	317	6	on	on	IN
cord-297078-pxggjaby	317	7	tmRNAmediated	tmrnamediated	JJ
cord-297078-pxggjaby	317	8	protein	protein	NN
cord-297078-pxggjaby	317	9	tagging	tagging	NN
cord-297078-pxggjaby	317	10	and	and	CC
cord-297078-pxggjaby	317	11	ribosome	ribosome	NN
cord-297078-pxggjaby	317	12	rescue	rescue	NN
cord-297078-pxggjaby	317	13	Archeal	Archeal	NNP
cord-297078-pxggjaby	317	14	DNA	DNA	NNP
cord-297078-pxggjaby	317	15	replication	replication	NN
cord-297078-pxggjaby	317	16	:	:	:
cord-297078-pxggjaby	317	17	eukaryal	eukaryal	NN
cord-297078-pxggjaby	317	18	proteins	protein	NNS
cord-297078-pxggjaby	317	19	in	in	IN
cord-297078-pxggjaby	317	20	a	a	DT
cord-297078-pxggjaby	317	21	bacterial	bacterial	JJ
cord-297078-pxggjaby	317	22	context	context	NN
cord-297078-pxggjaby	318	1	The	the	DT
cord-297078-pxggjaby	318	2	RNA	RNA	NNP
cord-297078-pxggjaby	318	3	moiety	moiety	NN
cord-297078-pxggjaby	318	4	of	of	IN
cord-297078-pxggjaby	318	5	ribonuclease	ribonuclease	NN
cord-297078-pxggjaby	318	6	P	p	NN
cord-297078-pxggjaby	318	7	is	be	VBZ
cord-297078-pxggjaby	318	8	the	the	DT
cord-297078-pxggjaby	318	9	catalytic	catalytic	JJ
cord-297078-pxggjaby	318	10	subunit	subunit	NN
cord-297078-pxggjaby	318	11	of	of	IN
cord-297078-pxggjaby	318	12	the	the	DT
cord-297078-pxggjaby	318	13	enzyme	enzyme	NN
cord-297078-pxggjaby	318	14	Nascent	Nascent	NNP
cord-297078-pxggjaby	318	15	RNA	RNA	NNP
cord-297078-pxggjaby	318	16	cleavage	cleavage	NN
cord-297078-pxggjaby	318	17	by	by	IN
cord-297078-pxggjaby	318	18	purified	purify	VBN
cord-297078-pxggjaby	318	19	ternary	ternary	JJ
cord-297078-pxggjaby	318	20	complexes	complex	NNS
cord-297078-pxggjaby	318	21	of	of	IN
cord-297078-pxggjaby	318	22	vaccinia	vaccinia	NN
cord-297078-pxggjaby	318	23	RNA	RNA	NNP
cord-297078-pxggjaby	318	24	polymerase	polymerase	NN
cord-297078-pxggjaby	318	25	Structure	Structure	NNP
cord-297078-pxggjaby	318	26	of	of	IN
cord-297078-pxggjaby	318	27	the	the	DT
cord-297078-pxggjaby	318	28	RNA	RNA	NNP
cord-297078-pxggjaby	318	29	-	-	HYPH
cord-297078-pxggjaby	318	30	dependent	dependent	JJ
cord-297078-pxggjaby	318	31	RNA	RNA	NNP
cord-297078-pxggjaby	318	32	polymerase	polymerase	NN
cord-297078-pxggjaby	318	33	of	of	IN
cord-297078-pxggjaby	318	34	poliovirus	poliovirus	NN
cord-297078-pxggjaby	319	1	The	the	DT
cord-297078-pxggjaby	319	2	genetic	genetic	JJ
cord-297078-pxggjaby	319	3	core	core	NN
cord-297078-pxggjaby	319	4	of	of	IN
cord-297078-pxggjaby	319	5	the	the	DT
cord-297078-pxggjaby	319	6	Universal	Universal	NNP
cord-297078-pxggjaby	319	7	Ancestor	Ancestor	NNP
cord-297078-pxggjaby	319	8	Transcription	Transcription	NNP
cord-297078-pxggjaby	319	9	factor	factor	NN
cord-297078-pxggjaby	319	10	S	S	NNP
cord-297078-pxggjaby	319	11	,	,	,
cord-297078-pxggjaby	319	12	a	a	DT
cord-297078-pxggjaby	319	13	cleavage	cleavage	NN
cord-297078-pxggjaby	319	14	induction	induction	NN
cord-297078-pxggjaby	319	15	factor	factor	NN
cord-297078-pxggjaby	319	16	of	of	IN
cord-297078-pxggjaby	319	17	the	the	DT
cord-297078-pxggjaby	319	18	archaeal	archaeal	JJ
cord-297078-pxggjaby	319	19	RNA	RNA	NNP
cord-297078-pxggjaby	319	20	polymerase	polymerase	NN
cord-297078-pxggjaby	319	21	Global	global	JJ
cord-297078-pxggjaby	319	22	transposon	transposon	NN
cord-297078-pxggjaby	319	23	mutagenesis	mutagenesis	NN
cord-297078-pxggjaby	319	24	and	and	CC
cord-297078-pxggjaby	319	25	a	a	DT
cord-297078-pxggjaby	319	26	minimal	minimal	JJ
cord-297078-pxggjaby	319	27	Mycoplasma	Mycoplasma	NNP
cord-297078-pxggjaby	319	28	genome	genome	NN
cord-297078-pxggjaby	319	29	A	a	DT
cord-297078-pxggjaby	319	30	multi	multi	JJ
cord-297078-pxggjaby	319	31	-	-	JJ
cord-297078-pxggjaby	319	32	functional	functional	JJ
cord-297078-pxggjaby	319	33	enzyme	enzyme	NN
cord-297078-pxggjaby	319	34	with	with	IN
cord-297078-pxggjaby	319	35	RNA	RNA	NNP
cord-297078-pxggjaby	319	36	polymerase	polymerase	NN
cord-297078-pxggjaby	319	37	and	and	CC
cord-297078-pxggjaby	319	38	RNase	rnase	NN
cord-297078-pxggjaby	319	39	activities	activity	NNS
cord-297078-pxggjaby	319	40	:	:	:
cord-297078-pxggjaby	319	41	molecular	molecular	JJ
cord-297078-pxggjaby	319	42	anatomy	anatomy	NN
cord-297078-pxggjaby	319	43	of	of	IN
cord-297078-pxggjaby	319	44	influenza	influenza	NN
cord-297078-pxggjaby	319	45	virus	virus	NN
cord-297078-pxggjaby	319	46	RNA	rna	NN
cord-297078-pxggjaby	319	47	polymerase	polymerase	NN
cord-297078-pxggjaby	319	48	Proofreading	proofreading	NN
cord-297078-pxggjaby	319	49	function	function	NN
cord-297078-pxggjaby	319	50	associated	associate	VBN
cord-297078-pxggjaby	319	51	with	with	IN
cord-297078-pxggjaby	319	52	the	the	DT
cord-297078-pxggjaby	319	53	RNA	RNA	NNP
cord-297078-pxggjaby	319	54	-	-	HYPH
cord-297078-pxggjaby	319	55	dependent	dependent	JJ
cord-297078-pxggjaby	319	56	RNA	RNA	NNP
cord-297078-pxggjaby	319	57	polymerase	polymerase	NN
cord-297078-pxggjaby	319	58	from	from	IN
cord-297078-pxggjaby	319	59	influenza	influenza	NN
cord-297078-pxggjaby	319	60	virus	virus	NN
cord-297078-pxggjaby	319	61	Compilation	compilation	NN
cord-297078-pxggjaby	319	62	and	and	CC
cord-297078-pxggjaby	319	63	alignment	alignment	NN
cord-297078-pxggjaby	319	64	of	of	IN
cord-297078-pxggjaby	319	65	DNA	dna	NN
cord-297078-pxggjaby	319	66	polymerase	polymerase	NN
cord-297078-pxggjaby	319	67	sequences	sequence	NNS
cord-297078-pxggjaby	319	68	Evolutionary	evolutionary	JJ
cord-297078-pxggjaby	319	69	connection	connection	NN
cord-297078-pxggjaby	319	70	between	between	IN
cord-297078-pxggjaby	319	71	the	the	DT
cord-297078-pxggjaby	319	72	catalytic	catalytic	JJ
cord-297078-pxggjaby	319	73	subunits	subunit	NNS
cord-297078-pxggjaby	319	74	of	of	IN
cord-297078-pxggjaby	319	75	DNA	dna	NN
cord-297078-pxggjaby	319	76	-	-	HYPH
cord-297078-pxggjaby	319	77	dependent	dependent	JJ
cord-297078-pxggjaby	319	78	RNA	RNA	NNP
cord-297078-pxggjaby	319	79	polymerases	polymerase	NNS
cord-297078-pxggjaby	319	80	and	and	CC
cord-297078-pxggjaby	319	81	eukaryotic	eukaryotic	JJ
cord-297078-pxggjaby	319	82	RNA	RNA	NNP
cord-297078-pxggjaby	319	83	-	-	HYPH
cord-297078-pxggjaby	319	84	dependent	dependent	JJ
cord-297078-pxggjaby	319	85	RNA	RNA	NNP
cord-297078-pxggjaby	319	86	polymerases	polymerase	NNS
cord-297078-pxggjaby	319	87	and	and	CC
cord-297078-pxggjaby	319	88	the	the	DT
cord-297078-pxggjaby	319	89	origin	origin	NN
cord-297078-pxggjaby	319	90	of	of	IN
cord-297078-pxggjaby	319	91	RNA	RNA	NNP
cord-297078-pxggjaby	319	92	polymerases	polymerase	NNS
cord-297078-pxggjaby	319	93	Relics	relic	NNS
cord-297078-pxggjaby	319	94	from	from	IN
cord-297078-pxggjaby	319	95	the	the	DT
cord-297078-pxggjaby	319	96	RNA	RNA	NNP
cord-297078-pxggjaby	319	97	world	world	NN
cord-297078-pxggjaby	319	98	Fidelity	Fidelity	NNP
cord-297078-pxggjaby	319	99	of	of	IN
cord-297078-pxggjaby	319	100	RNA	RNA	NNP
cord-297078-pxggjaby	319	101	polymerase	polymerase	NN
cord-297078-pxggjaby	319	102	II	II	NNP
cord-297078-pxggjaby	319	103	transcription	transcription	NN
cord-297078-pxggjaby	319	104	controlled	control	VBN
cord-297078-pxggjaby	319	105	by	by	IN
cord-297078-pxggjaby	319	106	elongation	elongation	NN
cord-297078-pxggjaby	319	107	factor	factor	NN
cord-297078-pxggjaby	319	108	TFIIS	TFIIS	NNP
cord-297078-pxggjaby	319	109	Function	function	NN
cord-297078-pxggjaby	319	110	and	and	CC
cord-297078-pxggjaby	319	111	structure	structure	NN
cord-297078-pxggjaby	319	112	relationships	relationship	NNS
cord-297078-pxggjaby	319	113	in	in	IN
cord-297078-pxggjaby	319	114	DNA	dna	NN
cord-297078-pxggjaby	319	115	polymerases	polymerase	NNS
cord-297078-pxggjaby	319	116	Prospects	prospect	NNS
cord-297078-pxggjaby	319	117	for	for	IN
cord-297078-pxggjaby	319	118	understanding	understand	VBG
cord-297078-pxggjaby	319	119	the	the	DT
cord-297078-pxggjaby	319	120	origin	origin	NN
cord-297078-pxggjaby	319	121	of	of	IN
cord-297078-pxggjaby	319	122	the	the	DT
cord-297078-pxggjaby	319	123	RNA	RNA	NNP
cord-297078-pxggjaby	319	124	world	world	NN
cord-297078-pxggjaby	320	1	The	the	DT
cord-297078-pxggjaby	320	2	RNA	RNA	NNP
cord-297078-pxggjaby	320	3	world	world	NN
cord-297078-pxggjaby	320	4	Complete	Complete	NNP
cord-297078-pxggjaby	320	5	RNA	RNA	NNP
cord-297078-pxggjaby	320	6	polymerase	polymerase	NN
cord-297078-pxggjaby	320	7	II	II	NNP
cord-297078-pxggjaby	320	8	elongation	elongation	NN
cord-297078-pxggjaby	320	9	complex	complex	JJ
cord-297078-pxggjaby	320	10	structure	structure	NN
cord-297078-pxggjaby	320	11	and	and	CC
cord-297078-pxggjaby	320	12	its	-PRON-	PRP$
cord-297078-pxggjaby	320	13	interactions	interaction	NNS
cord-297078-pxggjaby	320	14	with	with	IN
cord-297078-pxggjaby	320	15	NTP	NTP	NNP
cord-297078-pxggjaby	320	16	and	and	CC
cord-297078-pxggjaby	320	17	TFIIS	TFIIS	NNP
cord-297078-pxggjaby	320	18	Comparative	comparative	JJ
cord-297078-pxggjaby	320	19	genomics	genomic	NNS
cord-297078-pxggjaby	320	20	,	,	,
cord-297078-pxggjaby	320	21	minimal	minimal	JJ
cord-297078-pxggjaby	320	22	genesets	geneset	NNS
cord-297078-pxggjaby	320	23	and	and	CC
cord-297078-pxggjaby	320	24	the	the	DT
cord-297078-pxggjaby	320	25	Last	last	JJ
cord-297078-pxggjaby	320	26	Universal	Universal	NNP
cord-297078-pxggjaby	320	27	Common	Common	NNP
cord-297078-pxggjaby	320	28	Ancestor	Ancestor	NNP
cord-297078-pxggjaby	320	29	DNA	DNA	NNP
cord-297078-pxggjaby	320	30	replication	replication	NN
cord-297078-pxggjaby	320	31	Self	self	NN
cord-297078-pxggjaby	320	32	-	-	HYPH
cord-297078-pxggjaby	320	33	splicing	splice	VBG
cord-297078-pxggjaby	320	34	RNA	rna	NN
cord-297078-pxggjaby	320	35	:	:	:
cord-297078-pxggjaby	320	36	autoexcision	autoexcision	NN
cord-297078-pxggjaby	320	37	and	and	CC
cord-297078-pxggjaby	320	38	autocyclization	autocyclization	NN
cord-297078-pxggjaby	320	39	of	of	IN
cord-297078-pxggjaby	320	40	the	the	DT
cord-297078-pxggjaby	320	41	ribosomal	ribosomal	JJ
cord-297078-pxggjaby	320	42	RNA	RNA	NNP
cord-297078-pxggjaby	320	43	intervening	intervene	VBG
cord-297078-pxggjaby	320	44	sequence	sequence	NN
cord-297078-pxggjaby	320	45	of	of	IN
cord-297078-pxggjaby	320	46	Tetrahymena	Tetrahymena	NNP
cord-297078-pxggjaby	320	47	Titins	Titins	NNP
cord-297078-pxggjaby	320	48	:	:	:
cord-297078-pxggjaby	320	49	giant	giant	JJ
cord-297078-pxggjaby	320	50	proteins	protein	NNS
cord-297078-pxggjaby	320	51	in	in	IN
cord-297078-pxggjaby	320	52	charge	charge	NN
cord-297078-pxggjaby	320	53	of	of	IN
cord-297078-pxggjaby	320	54	muscle	muscle	NN
cord-297078-pxggjaby	320	55	ultrastructure	ultrastructure	NN
cord-297078-pxggjaby	320	56	and	and	CC
cord-297078-pxggjaby	320	57	elasticity	elasticity	NN
cord-297078-pxggjaby	320	58	Transcriptional	Transcriptional	NNP
cord-297078-pxggjaby	320	59	fidelity	fidelity	NN
cord-297078-pxggjaby	320	60	and	and	CC
cord-297078-pxggjaby	320	61	proofreading	proofreading	NN
cord-297078-pxggjaby	320	62	in	in	IN
cord-297078-pxggjaby	320	63	Archaea	Archaea	NNP
cord-297078-pxggjaby	320	64	and	and	CC
cord-297078-pxggjaby	320	65	implications	implication	NNS
cord-297078-pxggjaby	320	66	for	for	IN
cord-297078-pxggjaby	320	67	the	the	DT
cord-297078-pxggjaby	320	68	mechanism	mechanism	NN
cord-297078-pxggjaby	320	69	of	of	IN
cord-297078-pxggjaby	320	70	TFS	TFS	NNP
cord-297078-pxggjaby	320	71	-	-	HYPH
cord-297078-pxggjaby	320	72	induced	induce	VBN
cord-297078-pxggjaby	320	73	RNA	RNA	NNP
cord-297078-pxggjaby	320	74	cleavage	cleavage	NN
cord-297078-pxggjaby	320	75	Structural	structural	JJ
cord-297078-pxggjaby	320	76	mechanism	mechanism	NN
cord-297078-pxggjaby	320	77	of	of	IN
cord-297078-pxggjaby	320	78	allosteric	allosteric	JJ
cord-297078-pxggjaby	320	79	substrate	substrate	NN
cord-297078-pxggjaby	320	80	specificity	specificity	NN
cord-297078-pxggjaby	320	81	regulation	regulation	NN
cord-297078-pxggjaby	320	82	in	in	IN
cord-297078-pxggjaby	320	83	a	a	DT
cord-297078-pxggjaby	320	84	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	320	85	reductase	reductase	NN
cord-297078-pxggjaby	320	86	A	a	DT
cord-297078-pxggjaby	320	87	case	case	NN
cord-297078-pxggjaby	320	88	for	for	IN
cord-297078-pxggjaby	320	89	the	the	DT
cord-297078-pxggjaby	320	90	extreme	extreme	JJ
cord-297078-pxggjaby	320	91	antiquity	antiquity	NN
cord-297078-pxggjaby	320	92	of	of	IN
cord-297078-pxggjaby	320	93	recombination	recombination	NN
cord-297078-pxggjaby	321	1	Did	do	VBD
cord-297078-pxggjaby	321	2	DNA	dna	NN
cord-297078-pxggjaby	321	3	replication	replication	NN
cord-297078-pxggjaby	321	4	evolve	evolve	VBP
cord-297078-pxggjaby	321	5	twice	twice	RB
cord-297078-pxggjaby	321	6	independently	independently	RB
cord-297078-pxggjaby	321	7	?	?	.
cord-297078-pxggjaby	322	1	A	a	DT
cord-297078-pxggjaby	322	2	glycyl	glycyl	JJ
cord-297078-pxggjaby	322	3	radical	radical	JJ
cord-297078-pxggjaby	322	4	site	site	NN
cord-297078-pxggjaby	322	5	in	in	IN
cord-297078-pxggjaby	322	6	the	the	DT
cord-297078-pxggjaby	322	7	crystal	crystal	JJ
cord-297078-pxggjaby	322	8	structure	structure	NN
cord-297078-pxggjaby	322	9	of	of	IN
cord-297078-pxggjaby	322	10	a	a	DT
cord-297078-pxggjaby	322	11	class	class	NN
cord-297078-pxggjaby	322	12	III	iii	CD
cord-297078-pxggjaby	322	13	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	322	14	reductase	reductase	NN
cord-297078-pxggjaby	322	15	Mutation	Mutation	NNP
cord-297078-pxggjaby	322	16	accumulation	accumulation	NN
cord-297078-pxggjaby	322	17	in	in	IN
cord-297078-pxggjaby	322	18	transfer	transfer	NN
cord-297078-pxggjaby	322	19	RNAs	rna	NNS
cord-297078-pxggjaby	322	20	:	:	:
cord-297078-pxggjaby	322	21	molecular	molecular	JJ
cord-297078-pxggjaby	322	22	evidence	evidence	NN
cord-297078-pxggjaby	322	23	for	for	IN
cord-297078-pxggjaby	322	24	Muller#s	Muller#s	NNP
cord-297078-pxggjaby	322	25	ratchet	ratchet	NN
cord-297078-pxggjaby	322	26	in	in	IN
cord-297078-pxggjaby	322	27	mitochondrial	mitochondrial	JJ
cord-297078-pxggjaby	322	28	genomes	genome	NNS
cord-297078-pxggjaby	323	1	The	the	DT
cord-297078-pxggjaby	323	2	genome	genome	NN
cord-297078-pxggjaby	323	3	sequence	sequence	NN
cord-297078-pxggjaby	323	4	of	of	IN
cord-297078-pxggjaby	323	5	the	the	DT
cord-297078-pxggjaby	323	6	SARS	SARS	NNP
cord-297078-pxggjaby	323	7	-	-	HYPH
cord-297078-pxggjaby	323	8	associated	associate	VBN
cord-297078-pxggjaby	323	9	coronavirus	coronavirus	NN
cord-297078-pxggjaby	323	10	Algorithms	Algorithms	NNP
cord-297078-pxggjaby	323	11	for	for	IN
cord-297078-pxggjaby	323	12	computing	compute	VBG
cord-297078-pxggjaby	323	13	parsimonious	parsimonious	JJ
cord-297078-pxggjaby	323	14	evolutionary	evolutionary	JJ
cord-297078-pxggjaby	323	15	scenarios	scenario	NNS
cord-297078-pxggjaby	323	16	for	for	IN
cord-297078-pxggjaby	323	17	genome	genome	NN
cord-297078-pxggjaby	323	18	evolution	evolution	NN
cord-297078-pxggjaby	323	19	,	,	,
cord-297078-pxggjaby	323	20	the	the	DT
cord-297078-pxggjaby	323	21	last	last	JJ
cord-297078-pxggjaby	323	22	universal	universal	JJ
cord-297078-pxggjaby	323	23	common	common	JJ
cord-297078-pxggjaby	323	24	ancestor	ancestor	NN
cord-297078-pxggjaby	323	25	and	and	CC
cord-297078-pxggjaby	323	26	dominance	dominance	NN
cord-297078-pxggjaby	323	27	of	of	IN
cord-297078-pxggjaby	323	28	horizontal	horizontal	JJ
cord-297078-pxggjaby	323	29	gene	gene	NN
cord-297078-pxggjaby	323	30	transfer	transfer	NN
cord-297078-pxggjaby	323	31	in	in	IN
cord-297078-pxggjaby	323	32	the	the	DT
cord-297078-pxggjaby	323	33	evolution	evolution	NN
cord-297078-pxggjaby	323	34	of	of	IN
cord-297078-pxggjaby	323	35	prokaryotes	prokaryote	NNS
cord-297078-pxggjaby	324	1	The	the	DT
cord-297078-pxggjaby	324	2	involvement	involvement	NN
cord-297078-pxggjaby	324	3	of	of	IN
cord-297078-pxggjaby	324	4	RNA	RNA	NNP
cord-297078-pxggjaby	324	5	in	in	IN
cord-297078-pxggjaby	324	6	ribosome	ribosome	NN
cord-297078-pxggjaby	324	7	function	function	NN
cord-297078-pxggjaby	324	8	Viroid	viroid	JJ
cord-297078-pxggjaby	324	9	replication	replication	NN
cord-297078-pxggjaby	324	10	is	be	VBZ
cord-297078-pxggjaby	324	11	inhibited	inhibit	VBN
cord-297078-pxggjaby	324	12	by	by	IN
cord-297078-pxggjaby	324	13	alpha	alpha	NN
cord-297078-pxggjaby	324	14	-	-	HYPH
cord-297078-pxggjaby	324	15	amanitin	amanitin	NNP
cord-297078-pxggjaby	324	16	A	a	DT
cord-297078-pxggjaby	324	17	minimal	minimal	JJ
cord-297078-pxggjaby	324	18	gene	gene	NN
cord-297078-pxggjaby	324	19	set	set	VBN
cord-297078-pxggjaby	324	20	for	for	IN
cord-297078-pxggjaby	324	21	cellular	cellular	JJ
cord-297078-pxggjaby	324	22	life	life	NN
cord-297078-pxggjaby	324	23	derived	derive	VBN
cord-297078-pxggjaby	324	24	by	by	IN
cord-297078-pxggjaby	324	25	comparison	comparison	NN
cord-297078-pxggjaby	324	26	of	of	IN
cord-297078-pxggjaby	324	27	complete	complete	JJ
cord-297078-pxggjaby	324	28	bacterial	bacterial	JJ
cord-297078-pxggjaby	324	29	genomes	genome	NNS
cord-297078-pxggjaby	324	30	The	the	DT
cord-297078-pxggjaby	324	31	driving	drive	VBG
cord-297078-pxggjaby	324	32	force	force	NN
cord-297078-pxggjaby	324	33	for	for	IN
cord-297078-pxggjaby	324	34	molecular	molecular	JJ
cord-297078-pxggjaby	324	35	evolution	evolution	NN
cord-297078-pxggjaby	324	36	of	of	IN
cord-297078-pxggjaby	324	37	translation	translation	NN
cord-297078-pxggjaby	324	38	Structure	structure	NN
cord-297078-pxggjaby	324	39	and	and	CC
cord-297078-pxggjaby	324	40	function	function	NN
cord-297078-pxggjaby	324	41	of	of	IN
cord-297078-pxggjaby	324	42	the	the	DT
cord-297078-pxggjaby	324	43	transcription	transcription	NN
cord-297078-pxggjaby	324	44	elongation	elongation	NN
cord-297078-pxggjaby	324	45	factor	factor	NN
cord-297078-pxggjaby	324	46	GreB	GreB	NNS
cord-297078-pxggjaby	324	47	bound	bind	VBN
cord-297078-pxggjaby	324	48	to	to	IN
cord-297078-pxggjaby	324	49	bacterial	bacterial	JJ
cord-297078-pxggjaby	324	50	RNA	RNA	NNP
cord-297078-pxggjaby	324	51	polymerase	polymerase	NN
cord-297078-pxggjaby	324	52	Evolution	evolution	NN
cord-297078-pxggjaby	324	53	of	of	IN
cord-297078-pxggjaby	324	54	the	the	DT
cord-297078-pxggjaby	324	55	genetic	genetic	JJ
cord-297078-pxggjaby	324	56	apparatus	apparatus	NN
cord-297078-pxggjaby	325	1	Intrinsic	intrinsic	JJ
cord-297078-pxggjaby	325	2	transcript	transcript	NN
cord-297078-pxggjaby	325	3	cleavage	cleavage	NN
cord-297078-pxggjaby	325	4	activity	activity	NN
cord-297078-pxggjaby	325	5	of	of	IN
cord-297078-pxggjaby	325	6	RNA	rna	NN
cord-297078-pxggjaby	325	7	polymerase	polymerase	NN
cord-297078-pxggjaby	326	1	AlkB	AlkB	NNP
cord-297078-pxggjaby	326	2	restores	restore	VBZ
cord-297078-pxggjaby	326	3	the	the	DT
cord-297078-pxggjaby	326	4	biological	biological	JJ
cord-297078-pxggjaby	326	5	function	function	NN
cord-297078-pxggjaby	326	6	of	of	IN
cord-297078-pxggjaby	326	7	mRNA	mRNA	NNP
cord-297078-pxggjaby	326	8	and	and	CC
cord-297078-pxggjaby	326	9	tRNA	tRNA	NNP
cord-297078-pxggjaby	326	10	inactivated	inactivate	VBN
cord-297078-pxggjaby	326	11	by	by	IN
cord-297078-pxggjaby	326	12	chemical	chemical	JJ
cord-297078-pxggjaby	326	13	methylation	methylation	NN
cord-297078-pxggjaby	326	14	Characterization	characterization	NN
cord-297078-pxggjaby	326	15	of	of	IN
cord-297078-pxggjaby	326	16	a	a	DT
cord-297078-pxggjaby	326	17	viroid	viroid	RB
cord-297078-pxggjaby	326	18	-	-	HYPH
cord-297078-pxggjaby	326	19	derived	derive	VBN
cord-297078-pxggjaby	326	20	RNA	RNA	NNP
cord-297078-pxggjaby	326	21	promoter	promoter	NN
cord-297078-pxggjaby	326	22	for	for	IN
cord-297078-pxggjaby	326	23	the	the	DT
cord-297078-pxggjaby	326	24	DNA	dna	NN
cord-297078-pxggjaby	326	25	-	-	HYPH
cord-297078-pxggjaby	326	26	dependent	dependent	JJ
cord-297078-pxggjaby	326	27	RNA	RNA	NNP
cord-297078-pxggjaby	326	28	polymerase	polymerase	NN
cord-297078-pxggjaby	326	29	from	from	IN
cord-297078-pxggjaby	326	30	Escherichia	Escherichia	NNP
cord-297078-pxggjaby	326	31	coli	coli	NNS
cord-297078-pxggjaby	326	32	Binding	bind	VBG
cord-297078-pxggjaby	326	33	site	site	NN
cord-297078-pxggjaby	326	34	of	of	IN
cord-297078-pxggjaby	326	35	Escherichia	Escherichia	NNP
cord-297078-pxggjaby	326	36	coli	coli	NNS
cord-297078-pxggjaby	326	37	RNA	rna	NN
cord-297078-pxggjaby	326	38	polymerase	polymerase	NN
cord-297078-pxggjaby	326	39	to	to	IN
cord-297078-pxggjaby	326	40	an	an	DT
cord-297078-pxggjaby	326	41	RNA	RNA	NNP
cord-297078-pxggjaby	326	42	promoter	promoter	NN
cord-297078-pxggjaby	326	43	Overlapping	overlap	VBG
cord-297078-pxggjaby	326	44	messages	message	NNS
cord-297078-pxggjaby	326	45	and	and	CC
cord-297078-pxggjaby	326	46	survivability	survivability	NN
cord-297078-pxggjaby	327	1	The	the	DT
cord-297078-pxggjaby	327	2	nature	nature	NN
cord-297078-pxggjaby	327	3	of	of	IN
cord-297078-pxggjaby	327	4	the	the	DT
cord-297078-pxggjaby	327	5	last	last	JJ
cord-297078-pxggjaby	327	6	universal	universal	JJ
cord-297078-pxggjaby	327	7	common	common	JJ
cord-297078-pxggjaby	327	8	ancestor	ancestor	NN
cord-297078-pxggjaby	327	9	A	a	DT
cord-297078-pxggjaby	327	10	single	single	JJ
cord-297078-pxggjaby	327	11	mutation	mutation	NN
cord-297078-pxggjaby	327	12	in	in	IN
cord-297078-pxggjaby	327	13	poliovirus	poliovirus	NN
cord-297078-pxggjaby	327	14	RNA	rna	NN
cord-297078-pxggjaby	327	15	-	-	HYPH
cord-297078-pxggjaby	327	16	dependent	dependent	JJ
cord-297078-pxggjaby	327	17	RNA	RNA	NNP
cord-297078-pxggjaby	327	18	polymerase	polymerase	NN
cord-297078-pxggjaby	327	19	confers	confer	VBZ
cord-297078-pxggjaby	327	20	resistance	resistance	NN
cord-297078-pxggjaby	327	21	to	to	IN
cord-297078-pxggjaby	327	22	mutagenic	mutagenic	JJ
cord-297078-pxggjaby	327	23	nucleotide	nucleotide	JJ
cord-297078-pxggjaby	327	24	analogs	analog	NNS
cord-297078-pxggjaby	327	25	via	via	IN
cord-297078-pxggjaby	327	26	increased	increase	VBN
cord-297078-pxggjaby	327	27	fidelity	fidelity	NN
cord-297078-pxggjaby	328	1	Early	early	JJ
cord-297078-pxggjaby	328	2	evolution	evolution	NN
cord-297078-pxggjaby	328	3	:	:	:
cord-297078-pxggjaby	328	4	prokaryotes	prokaryote	NNS
cord-297078-pxggjaby	328	5	,	,	,
cord-297078-pxggjaby	328	6	the	the	DT
cord-297078-pxggjaby	328	7	new	new	JJ
cord-297078-pxggjaby	328	8	kids	kid	NNS
cord-297078-pxggjaby	328	9	on	on	IN
cord-297078-pxggjaby	328	10	the	the	DT
cord-297078-pxggjaby	328	11	block	block	NN
cord-297078-pxggjaby	328	12	Methyl	Methyl	NNP
cord-297078-pxggjaby	328	13	-	-	HYPH
cord-297078-pxggjaby	328	14	RNA	RNA	NNP
cord-297078-pxggjaby	328	15	:	:	:
cord-297078-pxggjaby	328	16	an	an	DT
cord-297078-pxggjaby	328	17	evolutionary	evolutionary	JJ
cord-297078-pxggjaby	328	18	bridge	bridge	NN
cord-297078-pxggjaby	328	19	between	between	IN
cord-297078-pxggjaby	328	20	RNA	RNA	NNP
cord-297078-pxggjaby	328	21	and	and	CC
cord-297078-pxggjaby	328	22	DNA	DNA	NNP
cord-297078-pxggjaby	328	23	?	?	.
cord-297078-pxggjaby	329	1	The	the	DT
cord-297078-pxggjaby	329	2	path	path	NN
cord-297078-pxggjaby	329	3	from	from	IN
cord-297078-pxggjaby	329	4	the	the	DT
cord-297078-pxggjaby	329	5	RNA	RNA	NNP
cord-297078-pxggjaby	329	6	world	world	NN
cord-297078-pxggjaby	330	1	The	the	DT
cord-297078-pxggjaby	330	2	evolution	evolution	NN
cord-297078-pxggjaby	330	3	of	of	IN
cord-297078-pxggjaby	330	4	the	the	DT
cord-297078-pxggjaby	330	5	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	330	6	reductases	reductase	NNS
cord-297078-pxggjaby	330	7	:	:	:
cord-297078-pxggjaby	331	1	much	much	RB
cord-297078-pxggjaby	331	2	ado	ado	NN
cord-297078-pxggjaby	331	3	about	about	IN
cord-297078-pxggjaby	331	4	oxygen	oxygen	NN
cord-297078-pxggjaby	331	5	High	high	JJ
cord-297078-pxggjaby	331	6	fidelity	fidelity	NN
cord-297078-pxggjaby	331	7	of	of	IN
cord-297078-pxggjaby	331	8	yellow	yellow	JJ
cord-297078-pxggjaby	331	9	fever	fever	NNP
cord-297078-pxggjaby	331	10	virus	virus	NN
cord-297078-pxggjaby	331	11	RNA	RNA	NNP
cord-297078-pxggjaby	331	12	polymerase	polymerase	NN
cord-297078-pxggjaby	331	13	Genetic	genetic	JJ
cord-297078-pxggjaby	331	14	error	error	NN
cord-297078-pxggjaby	331	15	and	and	CC
cord-297078-pxggjaby	331	16	genome	genome	NN
cord-297078-pxggjaby	331	17	design	design	NN
cord-297078-pxggjaby	331	18	Repair	repair	NN
cord-297078-pxggjaby	331	19	of	of	IN
cord-297078-pxggjaby	331	20	tRNAs	tRNAs	NNPS
cord-297078-pxggjaby	331	21	in	in	IN
cord-297078-pxggjaby	331	22	metazoan	metazoan	JJ
cord-297078-pxggjaby	331	23	mitochondria	mitochondrion	NNS
cord-297078-pxggjaby	331	24	Purification	purification	NN
cord-297078-pxggjaby	331	25	and	and	CC
cord-297078-pxggjaby	331	26	identification	identification	NN
cord-297078-pxggjaby	331	27	of	of	IN
cord-297078-pxggjaby	331	28	a	a	DT
cord-297078-pxggjaby	331	29	vaccinia	vaccinia	NN
cord-297078-pxggjaby	331	30	virus	virus	NN
cord-297078-pxggjaby	331	31	-	-	HYPH
cord-297078-pxggjaby	331	32	encoded	encode	VBN
cord-297078-pxggjaby	331	33	intermediate	intermediate	JJ
cord-297078-pxggjaby	331	34	stage	stage	NN
cord-297078-pxggjaby	331	35	promoter	promoter	NN
cord-297078-pxggjaby	331	36	-	-	HYPH
cord-297078-pxggjaby	331	37	specific	specific	JJ
cord-297078-pxggjaby	331	38	transcription	transcription	NN
cord-297078-pxggjaby	331	39	factor	factor	NN
cord-297078-pxggjaby	331	40	that	that	WDT
cord-297078-pxggjaby	331	41	has	have	VBZ
cord-297078-pxggjaby	331	42	homology	homology	NN
cord-297078-pxggjaby	331	43	to	to	IN
cord-297078-pxggjaby	331	44	eukaryotic	eukaryotic	JJ
cord-297078-pxggjaby	331	45	transcription	transcription	NN
cord-297078-pxggjaby	331	46	factor	factor	NN
cord-297078-pxggjaby	331	47	SII	SII	NNP
cord-297078-pxggjaby	331	48	(	(	-LRB-
cord-297078-pxggjaby	331	49	TFIIS	TFIIS	NNP
cord-297078-pxggjaby	331	50	)	)	-RRB-
cord-297078-pxggjaby	331	51	and	and	CC
cord-297078-pxggjaby	331	52	an	an	DT
cord-297078-pxggjaby	331	53	additional	additional	JJ
cord-297078-pxggjaby	331	54	role	role	NN
cord-297078-pxggjaby	331	55	as	as	IN
cord-297078-pxggjaby	331	56	a	a	DT
cord-297078-pxggjaby	331	57	viral	viral	JJ
cord-297078-pxggjaby	331	58	RNA	rna	NN
cord-297078-pxggjaby	331	59	polymerase	polymerase	NN
cord-297078-pxggjaby	331	60	subunit	subunit	NN
cord-297078-pxggjaby	331	61	Characterization	characterization	NN
cord-297078-pxggjaby	331	62	of	of	IN
cord-297078-pxggjaby	331	63	a	a	DT
cord-297078-pxggjaby	331	64	novel	novel	JJ
cord-297078-pxggjaby	331	65	coronavirus	coronavirus	NN
cord-297078-pxggjaby	331	66	associated	associate	VBN
cord-297078-pxggjaby	331	67	with	with	IN
cord-297078-pxggjaby	331	68	severe	severe	JJ
cord-297078-pxggjaby	331	69	acute	acute	JJ
cord-297078-pxggjaby	331	70	respiratory	respiratory	JJ
cord-297078-pxggjaby	331	71	syndrome	syndrome	NN
cord-297078-pxggjaby	331	72	Recombination	recombination	NN
cord-297078-pxggjaby	331	73	in	in	IN
cord-297078-pxggjaby	331	74	primeval	primeval	JJ
cord-297078-pxggjaby	331	75	genomes	genome	NNS
cord-297078-pxggjaby	331	76	:	:	:
cord-297078-pxggjaby	331	77	a	a	DT
cord-297078-pxggjaby	331	78	step	step	NN
cord-297078-pxggjaby	331	79	forward	forward	RB
cord-297078-pxggjaby	331	80	but	but	CC
cord-297078-pxggjaby	331	81	still	still	RB
cord-297078-pxggjaby	331	82	a	a	DT
cord-297078-pxggjaby	331	83	long	long	JJ
cord-297078-pxggjaby	331	84	leap	leap	NN
cord-297078-pxggjaby	331	85	from	from	IN
cord-297078-pxggjaby	331	86	maintaining	maintain	VBG
cord-297078-pxggjaby	331	87	a	a	DT
cord-297078-pxggjaby	331	88	sizable	sizable	JJ
cord-297078-pxggjaby	331	89	genome	genome	NN
cord-297078-pxggjaby	331	90	Nuclease	Nuclease	NNP
cord-297078-pxggjaby	331	91	activity	activity	NN
cord-297078-pxggjaby	331	92	of	of	IN
cord-297078-pxggjaby	331	93	T7	T7	NNP
cord-297078-pxggjaby	331	94	RNA	RNA	NNP
cord-297078-pxggjaby	331	95	polymerase	polymerase	NN
cord-297078-pxggjaby	331	96	and	and	CC
cord-297078-pxggjaby	331	97	the	the	DT
cord-297078-pxggjaby	331	98	heterogeneity	heterogeneity	NN
cord-297078-pxggjaby	331	99	of	of	IN
cord-297078-pxggjaby	331	100	transcription	transcription	NN
cord-297078-pxggjaby	331	101	elongation	elongation	NN
cord-297078-pxggjaby	331	102	complexes	complex	NNS
cord-297078-pxggjaby	331	103	Avoiding	avoid	VBG
cord-297078-pxggjaby	331	104	catch-22	catch-22	NN
cord-297078-pxggjaby	331	105	of	of	IN
cord-297078-pxggjaby	331	106	early	early	JJ
cord-297078-pxggjaby	331	107	evolution	evolution	NN
cord-297078-pxggjaby	331	108	by	by	IN
cord-297078-pxggjaby	331	109	stepwise	stepwise	JJ
cord-297078-pxggjaby	331	110	increase	increase	NN
cord-297078-pxggjaby	331	111	in	in	IN
cord-297078-pxggjaby	331	112	copying	copy	VBG
cord-297078-pxggjaby	331	113	fidelity	fidelity	NN
cord-297078-pxggjaby	331	114	Involvement	Involvement	NNP
cord-297078-pxggjaby	331	115	of	of	IN
cord-297078-pxggjaby	331	116	nuclear	nuclear	JJ
cord-297078-pxggjaby	331	117	DNA	dna	NN
cord-297078-pxggjaby	331	118	-	-	HYPH
cord-297078-pxggjaby	331	119	dependent	dependent	JJ
cord-297078-pxggjaby	331	120	RNA	RNA	NNP
cord-297078-pxggjaby	331	121	polymerases	polymerase	NNS
cord-297078-pxggjaby	331	122	in	in	IN
cord-297078-pxggjaby	331	123	potato	potato	NN
cord-297078-pxggjaby	331	124	spindle	spindle	NN
cord-297078-pxggjaby	331	125	tuber	tuber	NN
cord-297078-pxggjaby	331	126	viroid	viroid	NN
cord-297078-pxggjaby	331	127	replication	replication	NN
cord-297078-pxggjaby	331	128	:	:	:
cord-297078-pxggjaby	331	129	a	a	DT
cord-297078-pxggjaby	331	130	reevaluation	reevaluation	NN
cord-297078-pxggjaby	331	131	TFIIS	TFIIS	NNP
cord-297078-pxggjaby	331	132	binds	bind	VBZ
cord-297078-pxggjaby	331	133	to	to	IN
cord-297078-pxggjaby	331	134	mouse	mouse	NN
cord-297078-pxggjaby	331	135	RNA	RNA	NNP
cord-297078-pxggjaby	331	136	polymerase	polymerase	NN
cord-297078-pxggjaby	331	137	I	-PRON-	PRP
cord-297078-pxggjaby	331	138	and	and	CC
cord-297078-pxggjaby	331	139	stimulates	stimulate	VBZ
cord-297078-pxggjaby	331	140	transcript	transcript	NN
cord-297078-pxggjaby	331	141	elongation	elongation	NN
cord-297078-pxggjaby	331	142	and	and	CC
cord-297078-pxggjaby	331	143	hydrolytic	hydrolytic	JJ
cord-297078-pxggjaby	331	144	cleavage	cleavage	NN
cord-297078-pxggjaby	331	145	of	of	IN
cord-297078-pxggjaby	331	146	nascent	nascent	JJ
cord-297078-pxggjaby	331	147	rRNA	rrna	NN
cord-297078-pxggjaby	331	148	Backtracking	backtrack	VBG
cord-297078-pxggjaby	331	149	by	by	IN
cord-297078-pxggjaby	331	150	single	single	JJ
cord-297078-pxggjaby	331	151	RNA	RNA	NNP
cord-297078-pxggjaby	331	152	polymerase	polymerase	NN
cord-297078-pxggjaby	331	153	molecules	molecule	NNS
cord-297078-pxggjaby	331	154	observed	observe	VBD
cord-297078-pxggjaby	331	155	at	at	IN
cord-297078-pxggjaby	331	156	near	near	JJ
cord-297078-pxggjaby	331	157	-	-	HYPH
cord-297078-pxggjaby	331	158	base	base	NN
cord-297078-pxggjaby	331	159	-	-	HYPH
cord-297078-pxggjaby	331	160	pair	pair	NN
cord-297078-pxggjaby	331	161	resolution	resolution	NN
cord-297078-pxggjaby	331	162	RNase	rnase	NN
cord-297078-pxggjaby	331	163	-	-	HYPH
cord-297078-pxggjaby	331	164	like	like	JJ
cord-297078-pxggjaby	331	165	domain	domain	NN
cord-297078-pxggjaby	331	166	in	in	IN
cord-297078-pxggjaby	331	167	DNA	dna	NN
cord-297078-pxggjaby	331	168	-	-	HYPH
cord-297078-pxggjaby	331	169	directed	direct	VBN
cord-297078-pxggjaby	331	170	RNA	RNA	NNP
cord-297078-pxggjaby	331	171	polymerase	polymerase	NN
cord-297078-pxggjaby	331	172	II	II	NNP
cord-297078-pxggjaby	331	173	Use	Use	NNP
cord-297078-pxggjaby	331	174	of	of	IN
cord-297078-pxggjaby	331	175	DNA	DNA	NNP
cord-297078-pxggjaby	331	176	,	,	,
cord-297078-pxggjaby	331	177	RNA	RNA	NNP
cord-297078-pxggjaby	331	178	,	,	,
cord-297078-pxggjaby	331	179	and	and	CC
cord-297078-pxggjaby	331	180	chimeric	chimeric	JJ
cord-297078-pxggjaby	331	181	templates	template	NNS
cord-297078-pxggjaby	331	182	by	by	IN
cord-297078-pxggjaby	331	183	a	a	DT
cord-297078-pxggjaby	331	184	viral	viral	JJ
cord-297078-pxggjaby	331	185	RNAdependent	RNAdependent	NNP
cord-297078-pxggjaby	331	186	RNA	rna	NN
cord-297078-pxggjaby	331	187	polymerase	polymerase	NN
cord-297078-pxggjaby	331	188	:	:	:
cord-297078-pxggjaby	331	189	evolutionary	evolutionary	JJ
cord-297078-pxggjaby	331	190	implications	implication	NNS
cord-297078-pxggjaby	331	191	for	for	IN
cord-297078-pxggjaby	331	192	the	the	DT
cord-297078-pxggjaby	331	193	transition	transition	NN
cord-297078-pxggjaby	331	194	from	from	IN
cord-297078-pxggjaby	331	195	the	the	DT
cord-297078-pxggjaby	331	196	RNA	RNA	NNP
cord-297078-pxggjaby	331	197	to	to	IN
cord-297078-pxggjaby	331	198	the	the	DT
cord-297078-pxggjaby	331	199	DNA	dna	NN
cord-297078-pxggjaby	331	200	world	world	NN
cord-297078-pxggjaby	332	1	The	the	DT
cord-297078-pxggjaby	332	2	crystal	crystal	JJ
cord-297078-pxggjaby	332	3	structure	structure	NN
cord-297078-pxggjaby	332	4	of	of	IN
cord-297078-pxggjaby	332	5	class	class	NN
cord-297078-pxggjaby	332	6	II	II	NNP
cord-297078-pxggjaby	332	7	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	332	8	reductase	reductase	NN
cord-297078-pxggjaby	332	9	reveals	reveal	VBZ
cord-297078-pxggjaby	332	10	how	how	WRB
cord-297078-pxggjaby	332	11	an	an	DT
cord-297078-pxggjaby	332	12	allosterically	allosterically	RB
cord-297078-pxggjaby	332	13	regulated	regulate	VBN
cord-297078-pxggjaby	332	14	monomer	monomer	NN
cord-297078-pxggjaby	332	15	mimics	mimic	VBZ
cord-297078-pxggjaby	332	16	a	a	DT
cord-297078-pxggjaby	332	17	dimer	dimer	NN
cord-297078-pxggjaby	333	1	On	on	IN
cord-297078-pxggjaby	333	2	the	the	DT
cord-297078-pxggjaby	333	3	total	total	JJ
cord-297078-pxggjaby	333	4	number	number	NN
cord-297078-pxggjaby	333	5	of	of	IN
cord-297078-pxggjaby	333	6	genes	gene	NNS
cord-297078-pxggjaby	333	7	and	and	CC
cord-297078-pxggjaby	333	8	their	-PRON-	PRP$
cord-297078-pxggjaby	333	9	length	length	NN
cord-297078-pxggjaby	333	10	distribution	distribution	NN
cord-297078-pxggjaby	333	11	in	in	IN
cord-297078-pxggjaby	333	12	complete	complete	JJ
cord-297078-pxggjaby	333	13	microbial	microbial	JJ
cord-297078-pxggjaby	333	14	genomes	genome	NNS
cord-297078-pxggjaby	334	1	Unified	unified	JJ
cord-297078-pxggjaby	334	2	two	two	CD
cord-297078-pxggjaby	334	3	-	-	HYPH
cord-297078-pxggjaby	334	4	metal	metal	NN
cord-297078-pxggjaby	334	5	mechanism	mechanism	NN
cord-297078-pxggjaby	334	6	of	of	IN
cord-297078-pxggjaby	334	7	RNA	RNA	NNP
cord-297078-pxggjaby	334	8	synthesis	synthesis	NN
cord-297078-pxggjaby	334	9	and	and	CC
cord-297078-pxggjaby	334	10	degradation	degradation	NN
cord-297078-pxggjaby	334	11	by	by	IN
cord-297078-pxggjaby	334	12	RNA	RNA	NNP
cord-297078-pxggjaby	334	13	polymerase	polymerase	NN
cord-297078-pxggjaby	334	14	Donation	donation	NN
cord-297078-pxggjaby	334	15	of	of	IN
cord-297078-pxggjaby	334	16	catalytic	catalytic	JJ
cord-297078-pxggjaby	334	17	residues	residue	NNS
cord-297078-pxggjaby	334	18	to	to	IN
cord-297078-pxggjaby	334	19	RNA	RNA	NNP
cord-297078-pxggjaby	334	20	polymerase	polymerase	NN
cord-297078-pxggjaby	334	21	active	active	JJ
cord-297078-pxggjaby	334	22	center	center	NN
cord-297078-pxggjaby	334	23	by	by	IN
cord-297078-pxggjaby	334	24	transcription	transcription	NN
cord-297078-pxggjaby	334	25	factor	factor	NN
cord-297078-pxggjaby	334	26	Gre	Gre	NNP
cord-297078-pxggjaby	334	27	DNA	DNA	NNP
cord-297078-pxggjaby	334	28	polymerases	polymerase	NNS
cord-297078-pxggjaby	334	29	:	:	:
cord-297078-pxggjaby	334	30	structural	structural	JJ
cord-297078-pxggjaby	334	31	diversity	diversity	NN
cord-297078-pxggjaby	334	32	and	and	CC
cord-297078-pxggjaby	334	33	common	common	JJ
cord-297078-pxggjaby	334	34	mechanisms	mechanism	NNS
cord-297078-pxggjaby	335	1	A	a	DT
cord-297078-pxggjaby	335	2	general	general	JJ
cord-297078-pxggjaby	335	3	two	two	CD
cord-297078-pxggjaby	335	4	-	-	HYPH
cord-297078-pxggjaby	335	5	metal	metal	NN
cord-297078-pxggjaby	335	6	-	-	HYPH
cord-297078-pxggjaby	335	7	ion	ion	NN
cord-297078-pxggjaby	335	8	mechanism	mechanism	NN
cord-297078-pxggjaby	335	9	for	for	IN
cord-297078-pxggjaby	335	10	catalytic	catalytic	JJ
cord-297078-pxggjaby	335	11	RNA	RNA	NNP
cord-297078-pxggjaby	335	12	The	the	DT
cord-297078-pxggjaby	335	13	B12-dependent	B12-dependent	NNP
cord-297078-pxggjaby	335	14	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	335	15	reductase	reductase	NN
cord-297078-pxggjaby	335	16	from	from	IN
cord-297078-pxggjaby	335	17	the	the	DT
cord-297078-pxggjaby	335	18	archaebacterium	archaebacterium	NNP
cord-297078-pxggjaby	335	19	Thermoplasma	Thermoplasma	NNP
cord-297078-pxggjaby	335	20	acidophila	acidophila	NN
cord-297078-pxggjaby	335	21	:	:	:
cord-297078-pxggjaby	336	1	an	an	DT
cord-297078-pxggjaby	336	2	evolutionary	evolutionary	JJ
cord-297078-pxggjaby	336	3	solution	solution	NN
cord-297078-pxggjaby	336	4	to	to	IN
cord-297078-pxggjaby	336	5	the	the	DT
cord-297078-pxggjaby	336	6	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	336	7	reductase	reductase	NN
cord-297078-pxggjaby	336	8	conundrum	conundrum	NN
cord-297078-pxggjaby	336	9	Transcriptional	Transcriptional	NNP
cord-297078-pxggjaby	336	10	fidelity	fidelity	NN
cord-297078-pxggjaby	336	11	and	and	CC
cord-297078-pxggjaby	336	12	proofreading	proofreading	NN
cord-297078-pxggjaby	336	13	by	by	IN
cord-297078-pxggjaby	336	14	RNA	RNA	NNP
cord-297078-pxggjaby	336	15	polymerase	polymerase	NN
cord-297078-pxggjaby	336	16	II	II	NNP
cord-297078-pxggjaby	336	17	Ribonucleotide	Ribonucleotide	NNP
cord-297078-pxggjaby	336	18	reductases	reductase	NNS
cord-297078-pxggjaby	336	19	:	:	:
cord-297078-pxggjaby	336	20	divergent	divergent	JJ
cord-297078-pxggjaby	336	21	evolution	evolution	NN
cord-297078-pxggjaby	336	22	of	of	IN
cord-297078-pxggjaby	336	23	an	an	DT
cord-297078-pxggjaby	336	24	ancient	ancient	JJ
cord-297078-pxggjaby	336	25	enzyme	enzyme	NN
cord-297078-pxggjaby	336	26	Accounting	account	VBG
cord-297078-pxggjaby	336	27	for	for	IN
cord-297078-pxggjaby	336	28	evolutionary	evolutionary	JJ
cord-297078-pxggjaby	336	29	rate	rate	NN
cord-297078-pxggjaby	336	30	variation	variation	NN
cord-297078-pxggjaby	336	31	among	among	IN
cord-297078-pxggjaby	336	32	sequence	sequence	NN
cord-297078-pxggjaby	336	33	sites	site	NNS
cord-297078-pxggjaby	336	34	consistently	consistently	RB
cord-297078-pxggjaby	336	35	changes	change	VBZ
cord-297078-pxggjaby	336	36	universal	universal	JJ
cord-297078-pxggjaby	336	37	phylogenies	phylogeny	NNS
cord-297078-pxggjaby	336	38	deduced	deduce	VBN
cord-297078-pxggjaby	336	39	from	from	IN
cord-297078-pxggjaby	336	40	rRNA	rrna	NN
cord-297078-pxggjaby	336	41	and	and	CC
cord-297078-pxggjaby	336	42	protein	protein	NN
cord-297078-pxggjaby	336	43	-	-	HYPH
cord-297078-pxggjaby	336	44	coding	code	VBG
cord-297078-pxggjaby	336	45	genes	gene	NNS
cord-297078-pxggjaby	337	1	A	a	DT
cord-297078-pxggjaby	337	2	novel	novel	JJ
cord-297078-pxggjaby	337	3	RNA	rna	NN
cord-297078-pxggjaby	337	4	polymerase	polymerase	NN
cord-297078-pxggjaby	337	5	I	i	NN
cord-297078-pxggjaby	337	6	-	-	HYPH
cord-297078-pxggjaby	337	7	dependent	dependent	JJ
cord-297078-pxggjaby	337	8	RNase	rnase	NN
cord-297078-pxggjaby	337	9	activity	activity	NN
cord-297078-pxggjaby	337	10	that	that	WDT
cord-297078-pxggjaby	337	11	shortens	shorten	VBZ
cord-297078-pxggjaby	337	12	nascent	nascent	JJ
cord-297078-pxggjaby	337	13	transcripts	transcript	NNS
cord-297078-pxggjaby	337	14	from	from	IN
cord-297078-pxggjaby	337	15	the	the	DT
cord-297078-pxggjaby	337	16	3	3	CD
cord-297078-pxggjaby	337	17	#	#	NN
cord-297078-pxggjaby	337	18	end	end	NN
cord-297078-pxggjaby	337	19	Structure	structure	NN
cord-297078-pxggjaby	337	20	of	of	IN
cord-297078-pxggjaby	337	21	ribonucleotide	ribonucleotide	NN
cord-297078-pxggjaby	337	22	reductase	reductase	NN
cord-297078-pxggjaby	337	23	protein	protein	NN
cord-297078-pxggjaby	337	24	R1	R1	NNP
cord-297078-pxggjaby	337	25	Non	Non	NNP
cord-297078-pxggjaby	337	26	-	-	JJ
cord-297078-pxggjaby	337	27	stop	stop	JJ
cord-297078-pxggjaby	337	28	decay	decay	NN
cord-297078-pxggjaby	337	29	-	-	:
cord-297078-pxggjaby	337	30	a	a	DT
cord-297078-pxggjaby	337	31	new	new	JJ
cord-297078-pxggjaby	337	32	mRNA	mRNA	NNP
cord-297078-pxggjaby	337	33	surveillance	surveillance	NN
cord-297078-pxggjaby	337	34	pathway	pathway	NN
cord-297078-pxggjaby	338	1	A	a	DT
cord-297078-pxggjaby	338	2	hypothesis	hypothesis	NN
cord-297078-pxggjaby	338	3	for	for	IN
cord-297078-pxggjaby	338	4	DNA	dna	NN
cord-297078-pxggjaby	338	5	viruses	virus	NNS
cord-297078-pxggjaby	338	6	as	as	IN
cord-297078-pxggjaby	338	7	the	the	DT
cord-297078-pxggjaby	338	8	origin	origin	NN
cord-297078-pxggjaby	338	9	of	of	IN
cord-297078-pxggjaby	338	10	eukaryotic	eukaryotic	JJ
cord-297078-pxggjaby	338	11	replication	replication	NN
cord-297078-pxggjaby	338	12	proteins	protein	NNS
cord-297078-pxggjaby	338	13	Identification	identification	NN
cord-297078-pxggjaby	338	14	of	of	IN
cord-297078-pxggjaby	338	15	a	a	DT
cord-297078-pxggjaby	338	16	3#/5	3#/5	CD
cord-297078-pxggjaby	338	17	#	#	NN
cord-297078-pxggjaby	338	18	exonuclease	exonuclease	NN
cord-297078-pxggjaby	338	19	activity	activity	NN
cord-297078-pxggjaby	338	20	associated	associate	VBN
cord-297078-pxggjaby	338	21	with	with	IN
cord-297078-pxggjaby	338	22	human	human	JJ
cord-297078-pxggjaby	338	23	RNA	RNA	NNP
cord-297078-pxggjaby	338	24	polymerase	polymerase	NN
cord-297078-pxggjaby	338	25	II	II	NNP
cord-297078-pxggjaby	338	26	RNA	RNA	NNP
cord-297078-pxggjaby	338	27	species	specie	NNS
cord-297078-pxggjaby	338	28	that	that	WDT
cord-297078-pxggjaby	338	29	replicate	replicate	VBP
cord-297078-pxggjaby	338	30	with	with	IN
cord-297078-pxggjaby	338	31	DNA	dna	NN
cord-297078-pxggjaby	338	32	-	-	HYPH
cord-297078-pxggjaby	338	33	dependent	dependent	JJ
cord-297078-pxggjaby	338	34	RNA	RNA	NNP
cord-297078-pxggjaby	338	35	polymerase	polymerase	NN
cord-297078-pxggjaby	338	36	from	from	IN
cord-297078-pxggjaby	338	37	Escherichia	Escherichia	NNP
cord-297078-pxggjaby	338	38	coli	coli	NNS
cord-297078-pxggjaby	338	39	Coenzymes	Coenzymes	NNP
cord-297078-pxggjaby	338	40	as	as	IN
cord-297078-pxggjaby	338	41	fossils	fossil	NNS
cord-297078-pxggjaby	338	42	of	of	IN
cord-297078-pxggjaby	338	43	an	an	DT
cord-297078-pxggjaby	338	44	earlier	early	JJR
cord-297078-pxggjaby	338	45	metabolic	metabolic	JJ
cord-297078-pxggjaby	338	46	state	state	NN
cord-297078-pxggjaby	338	47	Hydrolytic	Hydrolytic	NNP
cord-297078-pxggjaby	338	48	cleavage	cleavage	NN
cord-297078-pxggjaby	338	49	of	of	IN
cord-297078-pxggjaby	338	50	nascent	nascent	JJ
cord-297078-pxggjaby	338	51	RNA	RNA	NNP
cord-297078-pxggjaby	338	52	in	in	IN
cord-297078-pxggjaby	338	53	RNA	RNA	NNP
cord-297078-pxggjaby	338	54	polymerase	polymerase	NN
cord-297078-pxggjaby	338	55	III	iii	CD
cord-297078-pxggjaby	338	56	ternary	ternary	JJ
cord-297078-pxggjaby	338	57	transcription	transcription	NN
cord-297078-pxggjaby	338	58	complexes	complex	NNS
cord-297078-pxggjaby	338	59	Curbing	curb	VBG
cord-297078-pxggjaby	338	60	the	the	DT
cord-297078-pxggjaby	338	61	nonsense	nonsense	NN
cord-297078-pxggjaby	338	62	:	:	:
cord-297078-pxggjaby	338	63	the	the	DT
cord-297078-pxggjaby	338	64	activation	activation	NN
cord-297078-pxggjaby	338	65	and	and	CC
cord-297078-pxggjaby	338	66	regulation	regulation	NN
cord-297078-pxggjaby	338	67	of	of	IN
cord-297078-pxggjaby	339	1	mRNA	mRNA	NNP
cord-297078-pxggjaby	339	2	surveillance	surveillance	NN
cord-297078-pxggjaby	339	3	Transcription	Transcription	NNP
cord-297078-pxggjaby	339	4	elongation	elongation	NN
cord-297078-pxggjaby	339	5	factor	factor	NN
cord-297078-pxggjaby	339	6	SII	SII	NNP
cord-297078-pxggjaby	340	1	The	the	DT
cord-297078-pxggjaby	340	2	genetic	genetic	JJ
cord-297078-pxggjaby	340	3	code	code	NN
cord-297078-pxggjaby	340	4	:	:	:
cord-297078-pxggjaby	340	5	The	the	DT
cord-297078-pxggjaby	340	6	molecular	molecular	JJ
cord-297078-pxggjaby	340	7	basis	basis	NN
cord-297078-pxggjaby	340	8	of	of	IN
cord-297078-pxggjaby	340	9	genetic	genetic	JJ
cord-297078-pxggjaby	340	10	expression	expression	NN
cord-297078-pxggjaby	340	11	Primordial	primordial	JJ
cord-297078-pxggjaby	340	12	genetics	genetic	NNS
cord-297078-pxggjaby	340	13	:	:	:
cord-297078-pxggjaby	340	14	phenotype	phenotype	NN
cord-297078-pxggjaby	340	15	of	of	IN
cord-297078-pxggjaby	340	16	the	the	DT
cord-297078-pxggjaby	340	17	ribocyte	ribocyte	NN
cord-297078-pxggjaby	341	1	A	a	DT
cord-297078-pxggjaby	341	2	reevaluation	reevaluation	NN
cord-297078-pxggjaby	341	3	of	of	IN
cord-297078-pxggjaby	341	4	the	the	DT
cord-297078-pxggjaby	341	5	higher	high	JJR
cord-297078-pxggjaby	341	6	taxonomy	taxonomy	NN
cord-297078-pxggjaby	341	7	of	of	IN
cord-297078-pxggjaby	341	8	viruses	virus	NNS
cord-297078-pxggjaby	341	9	based	base	VBN
cord-297078-pxggjaby	341	10	on	on	IN
cord-297078-pxggjaby	341	11	RNA	RNA	NNP
cord-297078-pxggjaby	341	12	polymerases	polymerase	NNS