id	sid	tid	token	lemma	pos
cord-285262-690kpupt	1	1	key	key	NN
cord-285262-690kpupt	1	2	:	:	:
cord-285262-690kpupt	2	1	cord-285262	cord-285262	NNP
cord-285262-690kpupt	2	2	-	-	HYPH
cord-285262-690kpupt	2	3	690kpupt	690kpupt	NNP
cord-285262-690kpupt	2	4	authors	author	NNS
cord-285262-690kpupt	2	5	:	:	:
cord-285262-690kpupt	2	6	Imre	Imre	NNP
cord-285262-690kpupt	2	7	,	,	,
cord-285262-690kpupt	2	8	Gergely	Gergely	NNP
cord-285262-690kpupt	2	9	title	title	NN
cord-285262-690kpupt	2	10	:	:	:
cord-285262-690kpupt	2	11	The	the	DT
cord-285262-690kpupt	2	12	involvement	involvement	NN
cord-285262-690kpupt	2	13	of	of	IN
cord-285262-690kpupt	2	14	regulated	regulated	JJ
cord-285262-690kpupt	2	15	cell	cell	NN
cord-285262-690kpupt	2	16	death	death	NN
cord-285262-690kpupt	2	17	forms	form	NNS
cord-285262-690kpupt	2	18	in	in	IN
cord-285262-690kpupt	2	19	modulating	modulate	VBG
cord-285262-690kpupt	2	20	the	the	DT
cord-285262-690kpupt	2	21	bacterial	bacterial	JJ
cord-285262-690kpupt	2	22	and	and	CC
cord-285262-690kpupt	2	23	viral	viral	JJ
cord-285262-690kpupt	2	24	pathogenesis	pathogenesis	NN
cord-285262-690kpupt	2	25	date	date	NN
cord-285262-690kpupt	2	26	:	:	:
cord-285262-690kpupt	2	27	2020	2020	CD
cord-285262-690kpupt	2	28	-	-	HYPH
cord-285262-690kpupt	2	29	01	01	CD
cord-285262-690kpupt	2	30	-	-	HYPH
cord-285262-690kpupt	2	31	27	27	CD
cord-285262-690kpupt	2	32	journal	journal	NN
cord-285262-690kpupt	2	33	:	:	:
cord-285262-690kpupt	3	1	Int	Int	NNP
cord-285262-690kpupt	3	2	Rev	Rev	NNP
cord-285262-690kpupt	3	3	Cell	Cell	NNP
cord-285262-690kpupt	3	4	Mol	Mol	NNP
cord-285262-690kpupt	3	5	Biol	Biol	NNP
cord-285262-690kpupt	3	6	DOI	DOI	NNP
cord-285262-690kpupt	3	7	:	:	:
cord-285262-690kpupt	4	1	10.1016	10.1016	CD
cord-285262-690kpupt	4	2	/	/	SYM
cord-285262-690kpupt	4	3	bs.ircmb.2019.12.008	bs.ircmb.2019.12.008	NNP
cord-285262-690kpupt	4	4	sha	sha	NNP
cord-285262-690kpupt	4	5	:	:	:
cord-285262-690kpupt	4	6	7b2af34d3c65cc3eda82560616c424a447139709	7b2af34d3c65cc3eda82560616c424a447139709	ADD
cord-285262-690kpupt	5	1	doc_id	doc_id	CD
cord-285262-690kpupt	5	2	:	:	:
cord-285262-690kpupt	5	3	285262	285262	CD
cord-285262-690kpupt	5	4	cord_uid	cord_uid	FW
cord-285262-690kpupt	5	5	:	:	:
cord-285262-690kpupt	6	1	690kpupt	690kpupt	NNP
cord-285262-690kpupt	7	1	Apoptosis	apoptosis	NN
cord-285262-690kpupt	7	2	,	,	,
cord-285262-690kpupt	7	3	necroptosis	necroptosis	NNP
cord-285262-690kpupt	7	4	and	and	CC
cord-285262-690kpupt	7	5	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	7	6	represent	represent	VBP
cord-285262-690kpupt	7	7	three	three	CD
cord-285262-690kpupt	7	8	distinct	distinct	JJ
cord-285262-690kpupt	7	9	types	type	NNS
cord-285262-690kpupt	7	10	of	of	IN
cord-285262-690kpupt	7	11	regulated	regulated	JJ
cord-285262-690kpupt	7	12	cell	cell	NN
cord-285262-690kpupt	7	13	death	death	NN
cord-285262-690kpupt	7	14	forms	form	NNS
cord-285262-690kpupt	7	15	,	,	,
cord-285262-690kpupt	7	16	which	which	WDT
cord-285262-690kpupt	7	17	play	play	VBP
cord-285262-690kpupt	7	18	significant	significant	JJ
cord-285262-690kpupt	7	19	roles	role	NNS
cord-285262-690kpupt	7	20	in	in	IN
cord-285262-690kpupt	7	21	response	response	NN
cord-285262-690kpupt	7	22	to	to	IN
cord-285262-690kpupt	7	23	viral	viral	JJ
cord-285262-690kpupt	7	24	and	and	CC
cord-285262-690kpupt	7	25	bacterial	bacterial	JJ
cord-285262-690kpupt	7	26	infections	infection	NNS
cord-285262-690kpupt	7	27	.	.	.
cord-285262-690kpupt	8	1	Whereas	whereas	IN
cord-285262-690kpupt	8	2	apoptosis	apoptosis	NN
cord-285262-690kpupt	8	3	is	be	VBZ
cord-285262-690kpupt	8	4	characterized	characterize	VBN
cord-285262-690kpupt	8	5	by	by	IN
cord-285262-690kpupt	8	6	cell	cell	NN
cord-285262-690kpupt	8	7	shrinkage	shrinkage	NN
cord-285262-690kpupt	8	8	,	,	,
cord-285262-690kpupt	8	9	nuclear	nuclear	JJ
cord-285262-690kpupt	8	10	condensation	condensation	NN
cord-285262-690kpupt	8	11	,	,	,
cord-285262-690kpupt	8	12	bleb	bleb	NNP
cord-285262-690kpupt	8	13	formation	formation	NN
cord-285262-690kpupt	8	14	and	and	CC
cord-285262-690kpupt	8	15	retained	retain	VBD
cord-285262-690kpupt	8	16	membrane	membrane	NN
cord-285262-690kpupt	8	17	integrity	integrity	NN
cord-285262-690kpupt	8	18	,	,	,
cord-285262-690kpupt	8	19	necroptosis	necroptosis	NNP
cord-285262-690kpupt	8	20	and	and	CC
cord-285262-690kpupt	8	21	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	8	22	exhibit	exhibit	NN
cord-285262-690kpupt	8	23	osmotic	osmotic	JJ
cord-285262-690kpupt	8	24	imbalance	imbalance	NN
cord-285262-690kpupt	8	25	driven	drive	VBN
cord-285262-690kpupt	8	26	cytoplasmic	cytoplasmic	JJ
cord-285262-690kpupt	8	27	swelling	swelling	NN
cord-285262-690kpupt	8	28	and	and	CC
cord-285262-690kpupt	8	29	early	early	JJ
cord-285262-690kpupt	8	30	membrane	membrane	NN
cord-285262-690kpupt	8	31	damage	damage	NN
cord-285262-690kpupt	8	32	.	.	.
cord-285262-690kpupt	9	1	These	these	DT
cord-285262-690kpupt	9	2	three	three	CD
cord-285262-690kpupt	9	3	cell	cell	NN
cord-285262-690kpupt	9	4	death	death	NN
cord-285262-690kpupt	9	5	forms	form	NNS
cord-285262-690kpupt	9	6	exert	exert	VBP
cord-285262-690kpupt	9	7	distinct	distinct	JJ
cord-285262-690kpupt	9	8	immune	immune	JJ
cord-285262-690kpupt	9	9	stimulatory	stimulatory	JJ
cord-285262-690kpupt	9	10	potential	potential	NN
cord-285262-690kpupt	9	11	.	.	.
cord-285262-690kpupt	10	1	The	the	DT
cord-285262-690kpupt	10	2	caspase	caspase	NN
cord-285262-690kpupt	10	3	driven	drive	VBN
cord-285262-690kpupt	10	4	apoptotic	apoptotic	JJ
cord-285262-690kpupt	10	5	cell	cell	NN
cord-285262-690kpupt	10	6	demise	demise	NN
cord-285262-690kpupt	10	7	is	be	VBZ
cord-285262-690kpupt	10	8	considered	consider	VBN
cord-285262-690kpupt	10	9	in	in	IN
cord-285262-690kpupt	10	10	many	many	JJ
cord-285262-690kpupt	10	11	circumstances	circumstance	NNS
cord-285262-690kpupt	10	12	as	as	IN
cord-285262-690kpupt	10	13	anti	anti	JJ
cord-285262-690kpupt	10	14	-	-	JJ
cord-285262-690kpupt	10	15	inflammatory	inflammatory	JJ
cord-285262-690kpupt	10	16	,	,	,
cord-285262-690kpupt	10	17	whereas	whereas	IN
cord-285262-690kpupt	10	18	the	the	DT
cord-285262-690kpupt	10	19	two	two	CD
cord-285262-690kpupt	10	20	lytic	lytic	JJ
cord-285262-690kpupt	10	21	cell	cell	NN
cord-285262-690kpupt	10	22	death	death	NN
cord-285262-690kpupt	10	23	modalities	modality	NNS
cord-285262-690kpupt	10	24	can	can	MD
cord-285262-690kpupt	10	25	efficiently	efficiently	RB
cord-285262-690kpupt	10	26	trigger	trigger	VB
cord-285262-690kpupt	10	27	immune	immune	JJ
cord-285262-690kpupt	10	28	response	response	NN
cord-285262-690kpupt	10	29	by	by	IN
cord-285262-690kpupt	10	30	releasing	release	VBG
cord-285262-690kpupt	10	31	damage	damage	NN
cord-285262-690kpupt	10	32	associated	associate	VBD
cord-285262-690kpupt	10	33	molecular	molecular	JJ
cord-285262-690kpupt	10	34	patterns	pattern	NNS
cord-285262-690kpupt	10	35	to	to	IN
cord-285262-690kpupt	10	36	the	the	DT
cord-285262-690kpupt	10	37	extracellular	extracellular	JJ
cord-285262-690kpupt	10	38	space	space	NN
cord-285262-690kpupt	10	39	.	.	.
cord-285262-690kpupt	11	1	The	the	DT
cord-285262-690kpupt	11	2	relevance	relevance	NN
cord-285262-690kpupt	11	3	of	of	IN
cord-285262-690kpupt	11	4	these	these	DT
cord-285262-690kpupt	11	5	cell	cell	NN
cord-285262-690kpupt	11	6	death	death	NN
cord-285262-690kpupt	11	7	modalities	modality	NNS
cord-285262-690kpupt	11	8	in	in	IN
cord-285262-690kpupt	11	9	infections	infection	NNS
cord-285262-690kpupt	11	10	can	can	MD
cord-285262-690kpupt	11	11	be	be	VB
cord-285262-690kpupt	11	12	best	well	RBS
cord-285262-690kpupt	11	13	demonstrated	demonstrate	VBN
cord-285262-690kpupt	11	14	by	by	IN
cord-285262-690kpupt	11	15	the	the	DT
cord-285262-690kpupt	11	16	presence	presence	NN
cord-285262-690kpupt	11	17	of	of	IN
cord-285262-690kpupt	11	18	viral	viral	JJ
cord-285262-690kpupt	11	19	proteins	protein	NNS
cord-285262-690kpupt	11	20	that	that	WDT
cord-285262-690kpupt	11	21	directly	directly	RB
cord-285262-690kpupt	11	22	interfere	interfere	VBP
cord-285262-690kpupt	11	23	with	with	IN
cord-285262-690kpupt	11	24	cell	cell	NN
cord-285262-690kpupt	11	25	death	death	NN
cord-285262-690kpupt	11	26	pathways	pathway	NNS
cord-285262-690kpupt	11	27	.	.	.
cord-285262-690kpupt	12	1	Conversely	conversely	RB
cord-285262-690kpupt	12	2	,	,	,
cord-285262-690kpupt	12	3	some	some	DT
cord-285262-690kpupt	12	4	pathogens	pathogen	NNS
cord-285262-690kpupt	12	5	hijack	hijack	VBP
cord-285262-690kpupt	12	6	the	the	DT
cord-285262-690kpupt	12	7	cell	cell	NN
cord-285262-690kpupt	12	8	death	death	NN
cord-285262-690kpupt	12	9	signaling	signal	VBG
cord-285262-690kpupt	12	10	routes	route	NNS
cord-285262-690kpupt	12	11	to	to	TO
cord-285262-690kpupt	12	12	initiate	initiate	VB
cord-285262-690kpupt	12	13	a	a	DT
cord-285262-690kpupt	12	14	targeted	targeted	JJ
cord-285262-690kpupt	12	15	attack	attack	NN
cord-285262-690kpupt	12	16	against	against	IN
cord-285262-690kpupt	12	17	the	the	DT
cord-285262-690kpupt	12	18	immune	immune	JJ
cord-285262-690kpupt	12	19	cells	cell	NNS
cord-285262-690kpupt	12	20	of	of	IN
cord-285262-690kpupt	12	21	the	the	DT
cord-285262-690kpupt	12	22	host	host	NN
cord-285262-690kpupt	12	23	,	,	,
cord-285262-690kpupt	12	24	and	and	CC
cord-285262-690kpupt	12	25	extracellular	extracellular	JJ
cord-285262-690kpupt	12	26	bacteria	bacteria	NNS
cord-285262-690kpupt	12	27	can	can	MD
cord-285262-690kpupt	12	28	benefit	benefit	VB
cord-285262-690kpupt	12	29	from	from	IN
cord-285262-690kpupt	12	30	the	the	DT
cord-285262-690kpupt	12	31	destruction	destruction	NN
cord-285262-690kpupt	12	32	of	of	IN
cord-285262-690kpupt	12	33	intact	intact	JJ
cord-285262-690kpupt	12	34	extracellular	extracellular	JJ
cord-285262-690kpupt	12	35	barriers	barrier	NNS
cord-285262-690kpupt	12	36	upon	upon	IN
cord-285262-690kpupt	12	37	cell	cell	NN
cord-285262-690kpupt	12	38	death	death	NN
cord-285262-690kpupt	12	39	induction	induction	NN
cord-285262-690kpupt	12	40	.	.	.
cord-285262-690kpupt	13	1	The	the	DT
cord-285262-690kpupt	13	2	complexity	complexity	NN
cord-285262-690kpupt	13	3	and	and	CC
cord-285262-690kpupt	13	4	the	the	DT
cord-285262-690kpupt	13	5	crosstalk	crosstalk	NN
cord-285262-690kpupt	13	6	between	between	IN
cord-285262-690kpupt	13	7	these	these	DT
cord-285262-690kpupt	13	8	cell	cell	NN
cord-285262-690kpupt	13	9	death	death	NN
cord-285262-690kpupt	13	10	modalities	modality	NNS
cord-285262-690kpupt	13	11	reflect	reflect	VBP
cord-285262-690kpupt	13	12	a	a	DT
cord-285262-690kpupt	13	13	continuous	continuous	JJ
cord-285262-690kpupt	13	14	evolutionary	evolutionary	JJ
cord-285262-690kpupt	13	15	race	race	NN
cord-285262-690kpupt	13	16	between	between	IN
cord-285262-690kpupt	13	17	pathogens	pathogen	NNS
cord-285262-690kpupt	13	18	and	and	CC
cord-285262-690kpupt	13	19	host	host	NN
cord-285262-690kpupt	13	20	.	.	.
cord-285262-690kpupt	14	1	This	this	DT
cord-285262-690kpupt	14	2	chapter	chapter	NN
cord-285262-690kpupt	14	3	discusses	discuss	VBZ
cord-285262-690kpupt	14	4	the	the	DT
cord-285262-690kpupt	14	5	current	current	JJ
cord-285262-690kpupt	14	6	advances	advance	NNS
cord-285262-690kpupt	14	7	in	in	IN
cord-285262-690kpupt	14	8	the	the	DT
cord-285262-690kpupt	14	9	research	research	NN
cord-285262-690kpupt	14	10	of	of	IN
cord-285262-690kpupt	14	11	cell	cell	NN
cord-285262-690kpupt	14	12	death	death	NN
cord-285262-690kpupt	14	13	signaling	signal	VBG
cord-285262-690kpupt	14	14	with	with	IN
cord-285262-690kpupt	14	15	regard	regard	NN
cord-285262-690kpupt	14	16	to	to	IN
cord-285262-690kpupt	14	17	viral	viral	JJ
cord-285262-690kpupt	14	18	and	and	CC
cord-285262-690kpupt	14	19	bacterial	bacterial	JJ
cord-285262-690kpupt	14	20	infections	infection	NNS
cord-285262-690kpupt	14	21	and	and	CC
cord-285262-690kpupt	14	22	describes	describe	VBZ
cord-285262-690kpupt	14	23	the	the	DT
cord-285262-690kpupt	14	24	network	network	NN
cord-285262-690kpupt	14	25	of	of	IN
cord-285262-690kpupt	14	26	the	the	DT
cord-285262-690kpupt	14	27	cell	cell	NN
cord-285262-690kpupt	14	28	death	death	NN
cord-285262-690kpupt	14	29	initiating	initiate	VBG
cord-285262-690kpupt	14	30	molecular	molecular	JJ
cord-285262-690kpupt	14	31	mechanisms	mechanism	NNS
cord-285262-690kpupt	14	32	that	that	WDT
cord-285262-690kpupt	14	33	selectively	selectively	RB
cord-285262-690kpupt	14	34	recognize	recognize	VBP
cord-285262-690kpupt	14	35	pathogen	pathogen	NN
cord-285262-690kpupt	14	36	associated	associate	VBD
cord-285262-690kpupt	14	37	molecular	molecular	JJ
cord-285262-690kpupt	14	38	patterns	pattern	NNS
cord-285262-690kpupt	14	39	.	.	.
cord-285262-690kpupt	15	1	Abstract	Abstract	NNP
cord-285262-690kpupt	15	2	Apoptosis	Apoptosis	NNP
cord-285262-690kpupt	15	3	,	,	,
cord-285262-690kpupt	15	4	necroptosis	necroptosis	NNP
cord-285262-690kpupt	15	5	and	and	CC
cord-285262-690kpupt	15	6	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	15	7	represent	represent	VBP
cord-285262-690kpupt	15	8	three	three	CD
cord-285262-690kpupt	15	9	distinct	distinct	JJ
cord-285262-690kpupt	15	10	types	type	NNS
cord-285262-690kpupt	15	11	of	of	IN
cord-285262-690kpupt	15	12	regulated	regulated	JJ
cord-285262-690kpupt	15	13	cell	cell	NN
cord-285262-690kpupt	15	14	death	death	NN
cord-285262-690kpupt	15	15	forms	form	NNS
cord-285262-690kpupt	15	16	,	,	,
cord-285262-690kpupt	15	17	which	which	WDT
cord-285262-690kpupt	15	18	play	play	VBP
cord-285262-690kpupt	15	19	significant	significant	JJ
cord-285262-690kpupt	15	20	roles	role	NNS
cord-285262-690kpupt	15	21	in	in	IN
cord-285262-690kpupt	15	22	response	response	NN
cord-285262-690kpupt	15	23	to	to	IN
cord-285262-690kpupt	15	24	viral	viral	JJ
cord-285262-690kpupt	15	25	and	and	CC
cord-285262-690kpupt	15	26	bacterial	bacterial	JJ
cord-285262-690kpupt	15	27	infections	infection	NNS
cord-285262-690kpupt	15	28	.	.	.
cord-285262-690kpupt	16	1	Whereas	whereas	IN
cord-285262-690kpupt	16	2	apoptosis	apoptosis	NN
cord-285262-690kpupt	16	3	is	be	VBZ
cord-285262-690kpupt	16	4	characterized	characterize	VBN
cord-285262-690kpupt	16	5	by	by	IN
cord-285262-690kpupt	16	6	cell	cell	NN
cord-285262-690kpupt	16	7	shrinkage	shrinkage	NN
cord-285262-690kpupt	16	8	,	,	,
cord-285262-690kpupt	16	9	nuclear	nuclear	JJ
cord-285262-690kpupt	16	10	condensation	condensation	NN
cord-285262-690kpupt	16	11	,	,	,
cord-285262-690kpupt	16	12	bleb	bleb	NNP
cord-285262-690kpupt	16	13	formation	formation	NN
cord-285262-690kpupt	16	14	and	and	CC
cord-285262-690kpupt	16	15	retained	retain	VBD
cord-285262-690kpupt	16	16	membrane	membrane	NN
cord-285262-690kpupt	16	17	integrity	integrity	NN
cord-285262-690kpupt	16	18	,	,	,
cord-285262-690kpupt	16	19	necroptosis	necroptosis	NNP
cord-285262-690kpupt	16	20	and	and	CC
cord-285262-690kpupt	16	21	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	16	22	exhibit	exhibit	NN
cord-285262-690kpupt	16	23	osmotic	osmotic	JJ
cord-285262-690kpupt	16	24	imbalance	imbalance	NN
cord-285262-690kpupt	16	25	driven	drive	VBN
cord-285262-690kpupt	16	26	cytoplasmic	cytoplasmic	JJ
cord-285262-690kpupt	16	27	swelling	swelling	NN
cord-285262-690kpupt	16	28	and	and	CC
cord-285262-690kpupt	16	29	early	early	JJ
cord-285262-690kpupt	16	30	membrane	membrane	NN
cord-285262-690kpupt	16	31	damage	damage	NN
cord-285262-690kpupt	16	32	.	.	.
cord-285262-690kpupt	17	1	These	these	DT
cord-285262-690kpupt	17	2	three	three	CD
cord-285262-690kpupt	17	3	cell	cell	NN
cord-285262-690kpupt	17	4	death	death	NN
cord-285262-690kpupt	17	5	forms	form	NNS
cord-285262-690kpupt	17	6	exert	exert	VBP
cord-285262-690kpupt	17	7	distinct	distinct	JJ
cord-285262-690kpupt	17	8	immune	immune	JJ
cord-285262-690kpupt	17	9	stimulatory	stimulatory	JJ
cord-285262-690kpupt	17	10	potential	potential	NN
cord-285262-690kpupt	17	11	.	.	.
cord-285262-690kpupt	18	1	The	the	DT
cord-285262-690kpupt	18	2	caspase	caspase	NN
cord-285262-690kpupt	18	3	driven	drive	VBN
cord-285262-690kpupt	18	4	apoptotic	apoptotic	JJ
cord-285262-690kpupt	18	5	cell	cell	NN
cord-285262-690kpupt	18	6	demise	demise	NN
cord-285262-690kpupt	18	7	is	be	VBZ
cord-285262-690kpupt	18	8	considered	consider	VBN
cord-285262-690kpupt	18	9	in	in	IN
cord-285262-690kpupt	18	10	many	many	JJ
cord-285262-690kpupt	18	11	circumstances	circumstance	NNS
cord-285262-690kpupt	18	12	as	as	IN
cord-285262-690kpupt	18	13	anti	anti	JJ
cord-285262-690kpupt	18	14	-	-	JJ
cord-285262-690kpupt	18	15	inflammatory	inflammatory	JJ
cord-285262-690kpupt	18	16	,	,	,
cord-285262-690kpupt	18	17	whereas	whereas	IN
cord-285262-690kpupt	18	18	the	the	DT
cord-285262-690kpupt	18	19	two	two	CD
cord-285262-690kpupt	18	20	lytic	lytic	JJ
cord-285262-690kpupt	18	21	cell	cell	NN
cord-285262-690kpupt	18	22	death	death	NN
cord-285262-690kpupt	18	23	modalities	modality	NNS
cord-285262-690kpupt	18	24	can	can	MD
cord-285262-690kpupt	18	25	efficiently	efficiently	RB
cord-285262-690kpupt	18	26	trigger	trigger	VB
cord-285262-690kpupt	18	27	immune	immune	JJ
cord-285262-690kpupt	18	28	response	response	NN
cord-285262-690kpupt	18	29	by	by	IN
cord-285262-690kpupt	18	30	releasing	release	VBG
cord-285262-690kpupt	18	31	damage	damage	NN
cord-285262-690kpupt	18	32	associated	associate	VBD
cord-285262-690kpupt	18	33	molecular	molecular	JJ
cord-285262-690kpupt	18	34	patterns	pattern	NNS
cord-285262-690kpupt	18	35	to	to	IN
cord-285262-690kpupt	18	36	the	the	DT
cord-285262-690kpupt	18	37	extracellular	extracellular	JJ
cord-285262-690kpupt	18	38	space	space	NN
cord-285262-690kpupt	18	39	.	.	.
cord-285262-690kpupt	19	1	The	the	DT
cord-285262-690kpupt	19	2	relevance	relevance	NN
cord-285262-690kpupt	19	3	of	of	IN
cord-285262-690kpupt	19	4	these	these	DT
cord-285262-690kpupt	19	5	cell	cell	NN
cord-285262-690kpupt	19	6	death	death	NN
cord-285262-690kpupt	19	7	modalities	modality	NNS
cord-285262-690kpupt	19	8	in	in	IN
cord-285262-690kpupt	19	9	infections	infection	NNS
cord-285262-690kpupt	19	10	can	can	MD
cord-285262-690kpupt	19	11	be	be	VB
cord-285262-690kpupt	19	12	best	well	RBS
cord-285262-690kpupt	19	13	demonstrated	demonstrate	VBN
cord-285262-690kpupt	19	14	by	by	IN
cord-285262-690kpupt	19	15	the	the	DT
cord-285262-690kpupt	19	16	presence	presence	NN
cord-285262-690kpupt	19	17	of	of	IN
cord-285262-690kpupt	19	18	viral	viral	JJ
cord-285262-690kpupt	19	19	proteins	protein	NNS
cord-285262-690kpupt	19	20	that	that	WDT
cord-285262-690kpupt	19	21	directly	directly	RB
cord-285262-690kpupt	19	22	interfere	interfere	VBP
cord-285262-690kpupt	19	23	with	with	IN
cord-285262-690kpupt	19	24	cell	cell	NN
cord-285262-690kpupt	19	25	death	death	NN
cord-285262-690kpupt	19	26	pathways	pathway	NNS
cord-285262-690kpupt	19	27	.	.	.
cord-285262-690kpupt	20	1	Conversely	conversely	RB
cord-285262-690kpupt	20	2	,	,	,
cord-285262-690kpupt	20	3	some	some	DT
cord-285262-690kpupt	20	4	pathogens	pathogen	NNS
cord-285262-690kpupt	21	1	In	in	IN
cord-285262-690kpupt	21	2	the	the	DT
cord-285262-690kpupt	21	3	late	late	JJ
cord-285262-690kpupt	21	4	1960s	1960	NNS
cord-285262-690kpupt	21	5	,	,	,
cord-285262-690kpupt	21	6	it	-PRON-	PRP
cord-285262-690kpupt	21	7	was	be	VBD
cord-285262-690kpupt	21	8	recognized	recognize	VBN
cord-285262-690kpupt	21	9	that	that	IN
cord-285262-690kpupt	21	10	cell	cell	NN
cord-285262-690kpupt	21	11	death	death	NN
cord-285262-690kpupt	21	12	could	could	MD
cord-285262-690kpupt	21	13	be	be	VB
cord-285262-690kpupt	21	14	considered	consider	VBN
cord-285262-690kpupt	21	15	as	as	IN
cord-285262-690kpupt	21	16	a	a	DT
cord-285262-690kpupt	21	17	regulated	regulated	JJ
cord-285262-690kpupt	21	18	process	process	NN
cord-285262-690kpupt	21	19	.	.	.
cord-285262-690kpupt	22	1	For	for	IN
cord-285262-690kpupt	22	2	the	the	DT
cord-285262-690kpupt	22	3	genetically	genetically	RB
cord-285262-690kpupt	22	4	programmed	program	VBN
cord-285262-690kpupt	22	5	,	,	,
cord-285262-690kpupt	22	6	regulated	regulated	JJ
cord-285262-690kpupt	22	7	cell	cell	NN
cord-285262-690kpupt	22	8	demise	demise	NN
cord-285262-690kpupt	22	9	the	the	DT
cord-285262-690kpupt	22	10	term	term	NN
cord-285262-690kpupt	22	11	apoptosis	apoptosis	NN
cord-285262-690kpupt	22	12	(	(	-LRB-
cord-285262-690kpupt	22	13	from	from	IN
cord-285262-690kpupt	22	14	Greek	Greek	NNP
cord-285262-690kpupt	22	15	:	:	:
cord-285262-690kpupt	22	16	"	"	``
cord-285262-690kpupt	22	17	falling	fall	VBG
cord-285262-690kpupt	22	18	off	off	RP
cord-285262-690kpupt	22	19	"	"	''
cord-285262-690kpupt	22	20	)	)	-RRB-
cord-285262-690kpupt	22	21	was	be	VBD
cord-285262-690kpupt	22	22	coined	coin	VBN
cord-285262-690kpupt	22	23	,	,	,
cord-285262-690kpupt	22	24	which	which	WDT
cord-285262-690kpupt	22	25	exhibited	exhibit	VBD
cord-285262-690kpupt	22	26	distinctive	distinctive	JJ
cord-285262-690kpupt	22	27	morphological	morphological	JJ
cord-285262-690kpupt	22	28	and	and	CC
cord-285262-690kpupt	22	29	molecular	molecular	JJ
cord-285262-690kpupt	22	30	patterns	pattern	NNS
cord-285262-690kpupt	22	31	(	(	-LRB-
cord-285262-690kpupt	22	32	Kerr	Kerr	NNP
cord-285262-690kpupt	22	33	et	et	NNP
cord-285262-690kpupt	22	34	al	al	NNP
cord-285262-690kpupt	22	35	.	.	NNP
cord-285262-690kpupt	22	36	,	,	,
cord-285262-690kpupt	22	37	1972	1972	CD
cord-285262-690kpupt	22	38	)	)	-RRB-
cord-285262-690kpupt	22	39	.	.	.
cord-285262-690kpupt	23	1	That	that	DT
cord-285262-690kpupt	23	2	time	time	NN
cord-285262-690kpupt	23	3	necrosis	necrosis	NN
cord-285262-690kpupt	23	4	was	be	VBD
cord-285262-690kpupt	23	5	interpreted	interpret	VBN
cord-285262-690kpupt	23	6	as	as	IN
cord-285262-690kpupt	23	7	a	a	DT
cord-285262-690kpupt	23	8	total	total	JJ
cord-285262-690kpupt	23	9	counterpart	counterpart	NN
cord-285262-690kpupt	23	10	of	of	IN
cord-285262-690kpupt	23	11	apoptosis	apoptosis	NN
cord-285262-690kpupt	23	12	,	,	,
cord-285262-690kpupt	23	13	a	a	DT
cord-285262-690kpupt	23	14	nonphysiological	nonphysiological	JJ
cord-285262-690kpupt	23	15	and	and	CC
cord-285262-690kpupt	23	16	non	non	JJ
cord-285262-690kpupt	23	17	-	-	JJ
cord-285262-690kpupt	23	18	regulated	regulated	JJ
cord-285262-690kpupt	23	19	,	,	,
cord-285262-690kpupt	23	20	lytic	lytic	JJ
cord-285262-690kpupt	23	21	cell	cell	NN
cord-285262-690kpupt	23	22	death	death	NN
cord-285262-690kpupt	23	23	modality	modality	NN
cord-285262-690kpupt	23	24	.	.	.
cord-285262-690kpupt	24	1	In	in	IN
cord-285262-690kpupt	24	2	the	the	DT
cord-285262-690kpupt	24	3	recent	recent	JJ
cord-285262-690kpupt	24	4	decades	decade	NNS
cord-285262-690kpupt	24	5	,	,	,
cord-285262-690kpupt	24	6	additional	additional	JJ
cord-285262-690kpupt	24	7	newly	newly	RB
cord-285262-690kpupt	24	8	discovered	discover	VBN
cord-285262-690kpupt	24	9	regulated	regulated	JJ
cord-285262-690kpupt	24	10	cell	cell	NN
cord-285262-690kpupt	24	11	death	death	NN
cord-285262-690kpupt	24	12	modalities	modality	NNS
cord-285262-690kpupt	24	13	have	have	VBP
cord-285262-690kpupt	24	14	been	be	VBN
cord-285262-690kpupt	24	15	added	add	VBN
cord-285262-690kpupt	24	16	to	to	IN
cord-285262-690kpupt	24	17	the	the	DT
cord-285262-690kpupt	24	18	list	list	NN
cord-285262-690kpupt	24	19	of	of	IN
cord-285262-690kpupt	24	20	cell	cell	NN
cord-285262-690kpupt	24	21	death	death	NN
cord-285262-690kpupt	24	22	types	type	NNS
cord-285262-690kpupt	24	23	(	(	-LRB-
cord-285262-690kpupt	24	24	Galluzzi	Galluzzi	NNP
cord-285262-690kpupt	24	25	et	et	NNP
cord-285262-690kpupt	24	26	al	al	NNP
cord-285262-690kpupt	24	27	.	.	NNP
cord-285262-690kpupt	24	28	,	,	,
cord-285262-690kpupt	24	29	2018	2018	CD
cord-285262-690kpupt	24	30	)	)	-RRB-
cord-285262-690kpupt	24	31	,	,	,
cord-285262-690kpupt	24	32	and	and	CC
cord-285262-690kpupt	24	33	it	-PRON-	PRP
cord-285262-690kpupt	24	34	became	become	VBD
cord-285262-690kpupt	24	35	evident	evident	JJ
cord-285262-690kpupt	24	36	that	that	IN
cord-285262-690kpupt	24	37	necrotic	necrotic	JJ
cord-285262-690kpupt	24	38	-	-	HYPH
cord-285262-690kpupt	24	39	like	like	JJ
cord-285262-690kpupt	24	40	,	,	,
cord-285262-690kpupt	24	41	lytic	lytic	JJ
cord-285262-690kpupt	24	42	cell	cell	NN
cord-285262-690kpupt	24	43	death	death	NN
cord-285262-690kpupt	24	44	can	can	MD
cord-285262-690kpupt	24	45	also	also	RB
cord-285262-690kpupt	24	46	take	take	VB
cord-285262-690kpupt	24	47	place	place	NN
cord-285262-690kpupt	24	48	in	in	IN
cord-285262-690kpupt	24	49	a	a	DT
cord-285262-690kpupt	24	50	regulated	regulated	JJ
cord-285262-690kpupt	24	51	manner	manner	NN
cord-285262-690kpupt	24	52	.	.	.
cord-285262-690kpupt	25	1	Apoptosis	apoptosis	NN
cord-285262-690kpupt	25	2	is	be	VBZ
cord-285262-690kpupt	25	3	a	a	DT
cord-285262-690kpupt	25	4	non	non	JJ
cord-285262-690kpupt	25	5	-	-	JJ
cord-285262-690kpupt	25	6	lytic	lytic	JJ
cord-285262-690kpupt	25	7	form	form	NN
cord-285262-690kpupt	25	8	of	of	IN
cord-285262-690kpupt	25	9	cell	cell	NN
cord-285262-690kpupt	25	10	death	death	NN
cord-285262-690kpupt	25	11	characterized	characterize	VBN
cord-285262-690kpupt	25	12	by	by	IN
cord-285262-690kpupt	25	13	nuclear	nuclear	JJ
cord-285262-690kpupt	25	14	condensation	condensation	NN
cord-285262-690kpupt	25	15	,	,	,
cord-285262-690kpupt	25	16	shrinkage	shrinkage	NN
cord-285262-690kpupt	25	17	of	of	IN
cord-285262-690kpupt	25	18	the	the	DT
cord-285262-690kpupt	25	19	cell	cell	NN
cord-285262-690kpupt	25	20	,	,	,
cord-285262-690kpupt	25	21	formation	formation	NN
cord-285262-690kpupt	25	22	of	of	IN
cord-285262-690kpupt	25	23	apoptotic	apoptotic	JJ
cord-285262-690kpupt	25	24	bodies	body	NNS
cord-285262-690kpupt	25	25	and	and	CC
cord-285262-690kpupt	25	26	preservation	preservation	NN
cord-285262-690kpupt	25	27	of	of	IN
cord-285262-690kpupt	25	28	the	the	DT
cord-285262-690kpupt	25	29	cytoplasm	cytoplasm	JJ
cord-285262-690kpupt	25	30	membrane	membrane	NN
cord-285262-690kpupt	25	31	integrity	integrity	NN
cord-285262-690kpupt	25	32	until	until	IN
cord-285262-690kpupt	25	33	the	the	DT
cord-285262-690kpupt	25	34	late	late	JJ
cord-285262-690kpupt	25	35	stages	stage	NNS
cord-285262-690kpupt	25	36	of	of	IN
cord-285262-690kpupt	25	37	the	the	DT
cord-285262-690kpupt	25	38	process	process	NN
cord-285262-690kpupt	25	39	(	(	-LRB-
cord-285262-690kpupt	25	40	Kerr	Kerr	NNP
cord-285262-690kpupt	25	41	et	et	NNP
cord-285262-690kpupt	25	42	al	al	NNP
cord-285262-690kpupt	25	43	.	.	NNP
cord-285262-690kpupt	25	44	,	,	,
cord-285262-690kpupt	25	45	1972	1972	CD
cord-285262-690kpupt	25	46	)	)	-RRB-
cord-285262-690kpupt	25	47	.	.	.
cord-285262-690kpupt	26	1	Importantly	importantly	RB
cord-285262-690kpupt	26	2	,	,	,
cord-285262-690kpupt	26	3	apoptosis	apoptosis	NN
cord-285262-690kpupt	26	4	actively	actively	RB
cord-285262-690kpupt	26	5	labels	label	VBZ
cord-285262-690kpupt	26	6	itself	-PRON-	PRP
cord-285262-690kpupt	26	7	by	by	IN
cord-285262-690kpupt	26	8	translocating	translocate	VBG
cord-285262-690kpupt	26	9	phosphatidylserine	phosphatidylserine	NN
cord-285262-690kpupt	26	10	(	(	-LRB-
cord-285262-690kpupt	26	11	PS	PS	NNP
cord-285262-690kpupt	26	12	)	)	-RRB-
cord-285262-690kpupt	26	13	to	to	IN
cord-285262-690kpupt	26	14	the	the	DT
cord-285262-690kpupt	26	15	outer	outer	JJ
cord-285262-690kpupt	26	16	leaflet	leaflet	NN
cord-285262-690kpupt	26	17	of	of	IN
cord-285262-690kpupt	26	18	the	the	DT
cord-285262-690kpupt	26	19	membrane	membrane	NN
cord-285262-690kpupt	26	20	lipid	lipid	NN
cord-285262-690kpupt	26	21	bilayer	bilayer	NN
cord-285262-690kpupt	26	22	.	.	.
cord-285262-690kpupt	27	1	The	the	DT
cord-285262-690kpupt	27	2	PS	PS	NNP
cord-285262-690kpupt	27	3	exposure	exposure	NN
cord-285262-690kpupt	27	4	on	on	IN
cord-285262-690kpupt	27	5	the	the	DT
cord-285262-690kpupt	27	6	outer	outer	JJ
cord-285262-690kpupt	27	7	surface	surface	NN
cord-285262-690kpupt	27	8	provides	provide	VBZ
cord-285262-690kpupt	27	9	a	a	DT
cord-285262-690kpupt	27	10	so	so	RB
cord-285262-690kpupt	27	11	-	-	HYPH
cord-285262-690kpupt	27	12	called	call	VBN
cord-285262-690kpupt	27	13	"	"	``
cord-285262-690kpupt	27	14	eat	eat	VB
cord-285262-690kpupt	27	15	me	-PRON-	PRP
cord-285262-690kpupt	27	16	"	"	``
cord-285262-690kpupt	27	17	signal	signal	NN
cord-285262-690kpupt	27	18	for	for	IN
cord-285262-690kpupt	27	19	the	the	DT
cord-285262-690kpupt	27	20	neighboring	neighboring	NN
cord-285262-690kpupt	27	21	monocytes	monocyte	NNS
cord-285262-690kpupt	27	22	and	and	CC
cord-285262-690kpupt	27	23	macrophages	macrophage	NNS
cord-285262-690kpupt	27	24	and	and	CC
cord-285262-690kpupt	27	25	ensuring	ensure	VBG
cord-285262-690kpupt	27	26	the	the	DT
cord-285262-690kpupt	27	27	clearance	clearance	NN
cord-285262-690kpupt	27	28	of	of	IN
cord-285262-690kpupt	27	29	the	the	DT
cord-285262-690kpupt	27	30	apoptotic	apoptotic	JJ
cord-285262-690kpupt	27	31	debris	debris	NN
cord-285262-690kpupt	27	32	(	(	-LRB-
cord-285262-690kpupt	27	33	Fadok	Fadok	NNP
cord-285262-690kpupt	27	34	et	et	FW
cord-285262-690kpupt	27	35	al	al	NNP
cord-285262-690kpupt	27	36	.	.	NNP
cord-285262-690kpupt	27	37	,	,	,
cord-285262-690kpupt	27	38	1992	1992	CD
cord-285262-690kpupt	27	39	)	)	-RRB-
cord-285262-690kpupt	27	40	.	.	.
cord-285262-690kpupt	28	1	These	these	DT
cord-285262-690kpupt	28	2	two	two	CD
cord-285262-690kpupt	28	3	main	main	JJ
cord-285262-690kpupt	28	4	attributes	attribute	NNS
cord-285262-690kpupt	28	5	qualify	qualify	VBP
cord-285262-690kpupt	28	6	apoptosis	apoptosis	NN
cord-285262-690kpupt	28	7	as	as	IN
cord-285262-690kpupt	28	8	a	a	DT
cord-285262-690kpupt	28	9	non	non	JJ
cord-285262-690kpupt	28	10	-	-	JJ
cord-285262-690kpupt	28	11	inflammatory	inflammatory	JJ
cord-285262-690kpupt	28	12	cell	cell	NN
cord-285262-690kpupt	28	13	death	death	NN
cord-285262-690kpupt	28	14	.	.	.
cord-285262-690kpupt	29	1	In	in	IN
cord-285262-690kpupt	29	2	contrast	contrast	NN
cord-285262-690kpupt	29	3	,	,	,
cord-285262-690kpupt	29	4	necroptosis	necroptosis	NNP
cord-285262-690kpupt	29	5	and	and	CC
cord-285262-690kpupt	29	6	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	29	7	are	be	VBP
cord-285262-690kpupt	29	8	lytic	lytic	JJ
cord-285262-690kpupt	29	9	cell	cell	NN
cord-285262-690kpupt	29	10	death	death	NN
cord-285262-690kpupt	29	11	modalities	modality	NNS
cord-285262-690kpupt	29	12	,	,	,
cord-285262-690kpupt	29	13	accompanied	accompany	VBN
cord-285262-690kpupt	29	14	by	by	IN
cord-285262-690kpupt	29	15	early	early	JJ
cord-285262-690kpupt	29	16	membrane	membrane	NN
cord-285262-690kpupt	29	17	rupture	rupture	NN
cord-285262-690kpupt	29	18	and	and	CC
cord-285262-690kpupt	29	19	osmotic	osmotic	JJ
cord-285262-690kpupt	29	20	imbalance	imbalance	NN
cord-285262-690kpupt	29	21	,	,	,
cord-285262-690kpupt	29	22	which	which	WDT
cord-285262-690kpupt	29	23	provoke	provoke	VBP
cord-285262-690kpupt	29	24	inflammatory	inflammatory	JJ
cord-285262-690kpupt	29	25	signals	signal	NNS
cord-285262-690kpupt	29	26	by	by	IN
cord-285262-690kpupt	29	27	releasing	release	VBG
cord-285262-690kpupt	29	28	damage	damage	NN
cord-285262-690kpupt	29	29	associated	associate	VBD
cord-285262-690kpupt	29	30	molecular	molecular	JJ
cord-285262-690kpupt	29	31	patterns	pattern	NNS
cord-285262-690kpupt	29	32	(	(	-LRB-
cord-285262-690kpupt	29	33	DAMPs	damp	NNS
cord-285262-690kpupt	29	34	)	)	-RRB-
cord-285262-690kpupt	29	35	to	to	IN
cord-285262-690kpupt	29	36	the	the	DT
cord-285262-690kpupt	29	37	extracellular	extracellular	JJ
cord-285262-690kpupt	29	38	space	space	NN
cord-285262-690kpupt	29	39	(	(	-LRB-
cord-285262-690kpupt	29	40	Galluzzi	Galluzzi	NNP
cord-285262-690kpupt	29	41	et	et	NNP
cord-285262-690kpupt	29	42	al	al	NNP
cord-285262-690kpupt	29	43	.	.	NNP
cord-285262-690kpupt	29	44	,	,	,
cord-285262-690kpupt	29	45	2018	2018	CD
cord-285262-690kpupt	29	46	)	)	-RRB-
cord-285262-690kpupt	29	47	.	.	.
cord-285262-690kpupt	30	1	It	-PRON-	PRP
cord-285262-690kpupt	30	2	is	be	VBZ
cord-285262-690kpupt	30	3	important	important	JJ
cord-285262-690kpupt	30	4	to	to	TO
cord-285262-690kpupt	30	5	note	note	VB
cord-285262-690kpupt	30	6	that	that	IN
cord-285262-690kpupt	30	7	the	the	DT
cord-285262-690kpupt	30	8	immunogenicity	immunogenicity	NN
cord-285262-690kpupt	30	9	of	of	IN
cord-285262-690kpupt	30	10	the	the	DT
cord-285262-690kpupt	30	11	cell	cell	NN
cord-285262-690kpupt	30	12	death	death	NN
cord-285262-690kpupt	30	13	is	be	VBZ
cord-285262-690kpupt	30	14	a	a	DT
cord-285262-690kpupt	30	15	more	more	RBR
cord-285262-690kpupt	30	16	complex	complex	JJ
cord-285262-690kpupt	30	17	process	process	NN
cord-285262-690kpupt	30	18	than	than	IN
cord-285262-690kpupt	30	19	above	above	IN
cord-285262-690kpupt	30	20	outlined	outline	VBN
cord-285262-690kpupt	30	21	.	.	.
cord-285262-690kpupt	31	1	The	the	DT
cord-285262-690kpupt	31	2	lytic	lytic	JJ
cord-285262-690kpupt	31	3	property	property	NN
cord-285262-690kpupt	31	4	of	of	IN
cord-285262-690kpupt	31	5	a	a	DT
cord-285262-690kpupt	31	6	cell	cell	NN
cord-285262-690kpupt	31	7	demise	demise	NN
cord-285262-690kpupt	31	8	does	do	VBZ
cord-285262-690kpupt	31	9	not	not	RB
cord-285262-690kpupt	31	10	necessarily	necessarily	RB
cord-285262-690kpupt	31	11	result	result	VB
cord-285262-690kpupt	31	12	in	in	IN
cord-285262-690kpupt	31	13	an	an	DT
cord-285262-690kpupt	31	14	immune	immune	JJ
cord-285262-690kpupt	31	15	stimulation	stimulation	NN
cord-285262-690kpupt	31	16	,	,	,
cord-285262-690kpupt	31	17	while	while	IN
cord-285262-690kpupt	31	18	the	the	DT
cord-285262-690kpupt	31	19	caspase-8	caspase-8	NNP
cord-285262-690kpupt	31	20	driven	drive	VBN
cord-285262-690kpupt	31	21	apoptosis	apoptosis	NN
cord-285262-690kpupt	31	22	may	may	MD
cord-285262-690kpupt	31	23	lead	lead	VB
cord-285262-690kpupt	31	24	to	to	IN
cord-285262-690kpupt	31	25	immunogenic	immunogenic	JJ
cord-285262-690kpupt	31	26	processes	process	NNS
cord-285262-690kpupt	31	27	(	(	-LRB-
cord-285262-690kpupt	31	28	Yatim	Yatim	NNP
cord-285262-690kpupt	31	29	et	et	NNP
cord-285262-690kpupt	31	30	al	al	NNP
cord-285262-690kpupt	31	31	.	.	NNP
cord-285262-690kpupt	31	32	,	,	,
cord-285262-690kpupt	31	33	2015	2015	CD
cord-285262-690kpupt	31	34	)	)	-RRB-
cord-285262-690kpupt	31	35	.	.	.
cord-285262-690kpupt	32	1	This	this	DT
cord-285262-690kpupt	32	2	also	also	RB
cord-285262-690kpupt	32	3	clearly	clearly	RB
cord-285262-690kpupt	32	4	indicates	indicate	VBZ
cord-285262-690kpupt	32	5	that	that	IN
cord-285262-690kpupt	32	6	the	the	DT
cord-285262-690kpupt	32	7	release	release	NN
cord-285262-690kpupt	32	8	of	of	IN
cord-285262-690kpupt	32	9	DAMPs	DAMPs	NNPS
cord-285262-690kpupt	32	10	is	be	VBZ
cord-285262-690kpupt	32	11	a	a	DT
cord-285262-690kpupt	32	12	signaling	signaling	NN
cord-285262-690kpupt	32	13	-	-	HYPH
cord-285262-690kpupt	32	14	dependent	dependent	JJ
cord-285262-690kpupt	32	15	,	,	,
cord-285262-690kpupt	32	16	actively	actively	RB
cord-285262-690kpupt	32	17	regulated	regulate	VBN
cord-285262-690kpupt	32	18	process	process	NN
cord-285262-690kpupt	32	19	.	.	.
cord-285262-690kpupt	33	1	The	the	DT
cord-285262-690kpupt	33	2	human	human	JJ
cord-285262-690kpupt	33	3	body	body	NN
cord-285262-690kpupt	33	4	developed	develop	VBD
cord-285262-690kpupt	33	5	elaborate	elaborate	JJ
cord-285262-690kpupt	33	6	strategies	strategy	NNS
cord-285262-690kpupt	33	7	to	to	TO
cord-285262-690kpupt	33	8	efficiently	efficiently	RB
cord-285262-690kpupt	33	9	avoid	avoid	VB
cord-285262-690kpupt	33	10	and	and	CC
cord-285262-690kpupt	33	11	eliminate	eliminate	VB
cord-285262-690kpupt	33	12	infectious	infectious	JJ
cord-285262-690kpupt	33	13	pathogens	pathogen	NNS
cord-285262-690kpupt	33	14	.	.	.
cord-285262-690kpupt	34	1	Two	two	CD
cord-285262-690kpupt	34	2	corner	corner	NN
cord-285262-690kpupt	34	3	stones	stone	NNS
cord-285262-690kpupt	34	4	of	of	IN
cord-285262-690kpupt	34	5	this	this	DT
cord-285262-690kpupt	34	6	response	response	NN
cord-285262-690kpupt	34	7	are	be	VBP
cord-285262-690kpupt	34	8	the	the	DT
cord-285262-690kpupt	34	9	innate	innate	JJ
cord-285262-690kpupt	34	10	and	and	CC
cord-285262-690kpupt	34	11	the	the	DT
cord-285262-690kpupt	34	12	adaptive	adaptive	JJ
cord-285262-690kpupt	34	13	immune	immune	NN
cord-285262-690kpupt	34	14	signaling	signaling	NN
cord-285262-690kpupt	34	15	,	,	,
cord-285262-690kpupt	34	16	which	which	WDT
cord-285262-690kpupt	34	17	also	also	RB
cord-285262-690kpupt	34	18	include	include	VBP
cord-285262-690kpupt	34	19	controlled	control	VBN
cord-285262-690kpupt	34	20	killing	killing	NN
cord-285262-690kpupt	34	21	/	/	SYM
cord-285262-690kpupt	34	22	self	self	NN
cord-285262-690kpupt	34	23	-	-	HYPH
cord-285262-690kpupt	34	24	killing	kill	VBG
cord-285262-690kpupt	34	25	mechanisms	mechanism	NNS
cord-285262-690kpupt	34	26	of	of	IN
cord-285262-690kpupt	34	27	the	the	DT
cord-285262-690kpupt	34	28	infected	infected	JJ
cord-285262-690kpupt	34	29	host	host	NN
cord-285262-690kpupt	34	30	cells	cell	NNS
cord-285262-690kpupt	34	31	(	(	-LRB-
cord-285262-690kpupt	34	32	Jorgensen	Jorgensen	NNP
cord-285262-690kpupt	34	33	et	et	NNP
cord-285262-690kpupt	34	34	al	al	NNP
cord-285262-690kpupt	34	35	.	.	NNP
cord-285262-690kpupt	34	36	,	,	,
cord-285262-690kpupt	34	37	2017	2017	CD
cord-285262-690kpupt	34	38	)	)	-RRB-
cord-285262-690kpupt	34	39	.	.	.
cord-285262-690kpupt	35	1	This	this	DT
cord-285262-690kpupt	35	2	review	review	NN
cord-285262-690kpupt	35	3	focuses	focus	VBZ
cord-285262-690kpupt	35	4	on	on	IN
cord-285262-690kpupt	35	5	the	the	DT
cord-285262-690kpupt	35	6	infection	infection	NN
cord-285262-690kpupt	35	7	related	relate	VBN
cord-285262-690kpupt	35	8	aspects	aspect	NNS
cord-285262-690kpupt	35	9	of	of	IN
cord-285262-690kpupt	35	10	regulated	regulated	JJ
cord-285262-690kpupt	35	11	cell	cell	NN
cord-285262-690kpupt	35	12	death	death	NN
cord-285262-690kpupt	35	13	forms	form	NNS
cord-285262-690kpupt	35	14	,	,	,
cord-285262-690kpupt	35	15	which	which	WDT
cord-285262-690kpupt	35	16	in	in	IN
cord-285262-690kpupt	35	17	many	many	JJ
cord-285262-690kpupt	35	18	instances	instance	NNS
cord-285262-690kpupt	35	19	provide	provide	VBP
cord-285262-690kpupt	35	20	benefit	benefit	NN
cord-285262-690kpupt	35	21	for	for	IN
cord-285262-690kpupt	35	22	the	the	DT
cord-285262-690kpupt	35	23	hosts	host	NNS
cord-285262-690kpupt	35	24	by	by	IN
cord-285262-690kpupt	35	25	destroying	destroy	VBG
cord-285262-690kpupt	35	26	the	the	DT
cord-285262-690kpupt	35	27	intracellular	intracellular	JJ
cord-285262-690kpupt	35	28	niche	niche	NN
cord-285262-690kpupt	35	29	of	of	IN
cord-285262-690kpupt	35	30	the	the	DT
cord-285262-690kpupt	35	31	pathogen	pathogen	NN
cord-285262-690kpupt	35	32	.	.	.
cord-285262-690kpupt	36	1	Nevertheless	nevertheless	RB
cord-285262-690kpupt	36	2	,	,	,
cord-285262-690kpupt	36	3	it	-PRON-	PRP
cord-285262-690kpupt	36	4	is	be	VBZ
cord-285262-690kpupt	36	5	evident	evident	JJ
cord-285262-690kpupt	36	6	that	that	IN
cord-285262-690kpupt	36	7	some	some	DT
cord-285262-690kpupt	36	8	extracellular	extracellular	JJ
cord-285262-690kpupt	36	9	pathogens	pathogen	NNS
cord-285262-690kpupt	36	10	-	-	:
cord-285262-690kpupt	36	11	and	and	CC
cord-285262-690kpupt	36	12	also	also	RB
cord-285262-690kpupt	36	13	intracellular	intracellular	JJ
cord-285262-690kpupt	36	14	ones	one	NNS
cord-285262-690kpupt	36	15	-	-	,
cord-285262-690kpupt	36	16	can	can	MD
cord-285262-690kpupt	36	17	benefit	benefit	VB
cord-285262-690kpupt	36	18	from	from	IN
cord-285262-690kpupt	36	19	the	the	DT
cord-285262-690kpupt	36	20	death	death	NN
cord-285262-690kpupt	36	21	of	of	IN
cord-285262-690kpupt	36	22	the	the	DT
cord-285262-690kpupt	36	23	host	host	NN
cord-285262-690kpupt	36	24	cells	cell	NNS
cord-285262-690kpupt	36	25	.	.	.
cord-285262-690kpupt	37	1	In	in	IN
cord-285262-690kpupt	37	2	this	this	DT
cord-285262-690kpupt	37	3	chapter	chapter	NN
cord-285262-690kpupt	37	4	,	,	,
cord-285262-690kpupt	37	5	based	base	VBN
cord-285262-690kpupt	37	6	on	on	IN
cord-285262-690kpupt	37	7	the	the	DT
cord-285262-690kpupt	37	8	current	current	JJ
cord-285262-690kpupt	37	9	advances	advance	NNS
cord-285262-690kpupt	37	10	in	in	IN
cord-285262-690kpupt	37	11	the	the	DT
cord-285262-690kpupt	37	12	research	research	NN
cord-285262-690kpupt	37	13	,	,	,
cord-285262-690kpupt	37	14	we	-PRON-	PRP
cord-285262-690kpupt	37	15	give	give	VBP
cord-285262-690kpupt	37	16	a	a	DT
cord-285262-690kpupt	37	17	detailed	detailed	JJ
cord-285262-690kpupt	37	18	description	description	NN
cord-285262-690kpupt	37	19	about	about	IN
cord-285262-690kpupt	37	20	the	the	DT
cord-285262-690kpupt	37	21	key	key	JJ
cord-285262-690kpupt	37	22	cell	cell	NN
cord-285262-690kpupt	37	23	death	death	NN
cord-285262-690kpupt	37	24	modalities	modality	NNS
cord-285262-690kpupt	37	25	,	,	,
cord-285262-690kpupt	37	26	including	include	VBG
cord-285262-690kpupt	37	27	apoptosis	apoptosis	NN
cord-285262-690kpupt	37	28	,	,	,
cord-285262-690kpupt	37	29	necroptosis	necroptosis	NNP
cord-285262-690kpupt	37	30	and	and	CC
cord-285262-690kpupt	37	31	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	37	32	emerging	emerge	VBG
cord-285262-690kpupt	37	33	in	in	IN
cord-285262-690kpupt	37	34	response	response	NN
cord-285262-690kpupt	37	35	to	to	IN
cord-285262-690kpupt	37	36	pathogenic	pathogenic	JJ
cord-285262-690kpupt	37	37	insults	insult	NNS
cord-285262-690kpupt	37	38	,	,	,
cord-285262-690kpupt	37	39	and	and	CC
cord-285262-690kpupt	37	40	we	-PRON-	PRP
cord-285262-690kpupt	37	41	discuss	discuss	VBP
cord-285262-690kpupt	37	42	how	how	WRB
cord-285262-690kpupt	37	43	bacterial	bacterial	JJ
cord-285262-690kpupt	37	44	and	and	CC
cord-285262-690kpupt	37	45	viral	viral	JJ
cord-285262-690kpupt	37	46	infections	infection	NNS
cord-285262-690kpupt	37	47	can	can	MD
cord-285262-690kpupt	37	48	modulate	modulate	VB
cord-285262-690kpupt	37	49	these	these	DT
cord-285262-690kpupt	37	50	signaling	signal	VBG
cord-285262-690kpupt	37	51	pathways	pathway	NNS
cord-285262-690kpupt	37	52	.	.	.
cord-285262-690kpupt	38	1	Apoptosis	apoptosis	NN
cord-285262-690kpupt	38	2	is	be	VBZ
cord-285262-690kpupt	38	3	conducted	conduct	VBN
cord-285262-690kpupt	38	4	by	by	IN
cord-285262-690kpupt	38	5	caspase	caspase	NN
cord-285262-690kpupt	38	6	activation	activation	NN
cord-285262-690kpupt	38	7	.	.	.
cord-285262-690kpupt	39	1	Caspases	caspase	NNS
cord-285262-690kpupt	39	2	are	be	VBP
cord-285262-690kpupt	39	3	cysteine	cysteine	NN
cord-285262-690kpupt	39	4	-	-	HYPH
cord-285262-690kpupt	39	5	driven	drive	VBN
cord-285262-690kpupt	39	6	and	and	CC
cord-285262-690kpupt	39	7	aspartate	aspartate	NN
cord-285262-690kpupt	39	8	-	-	HYPH
cord-285262-690kpupt	39	9	directed	direct	VBN
cord-285262-690kpupt	39	10	peptidases	peptidase	NNS
cord-285262-690kpupt	39	11	,	,	,
cord-285262-690kpupt	39	12	which	which	WDT
cord-285262-690kpupt	39	13	present	present	VBP
cord-285262-690kpupt	39	14	in	in	IN
cord-285262-690kpupt	39	15	inactive	inactive	JJ
cord-285262-690kpupt	39	16	forms	form	NNS
cord-285262-690kpupt	39	17	,	,	,
cord-285262-690kpupt	39	18	and	and	CC
cord-285262-690kpupt	39	19	become	become	VB
cord-285262-690kpupt	39	20	cleaved	cleave	VBN
cord-285262-690kpupt	39	21	and	and	CC
cord-285262-690kpupt	39	22	activated	activate	VBN
cord-285262-690kpupt	39	23	upon	upon	IN
cord-285262-690kpupt	39	24	selective	selective	JJ
cord-285262-690kpupt	39	25	apoptotic	apoptotic	JJ
cord-285262-690kpupt	39	26	stimulation	stimulation	NN
cord-285262-690kpupt	39	27	(	(	-LRB-
cord-285262-690kpupt	39	28	Cohen	Cohen	NNP
cord-285262-690kpupt	39	29	,	,	,
cord-285262-690kpupt	39	30	1997	1997	CD
cord-285262-690kpupt	39	31	)	)	-RRB-
cord-285262-690kpupt	39	32	.	.	.
cord-285262-690kpupt	40	1	The	the	DT
cord-285262-690kpupt	40	2	initiator	initiator	NN
cord-285262-690kpupt	40	3	caspases	caspase	NNS
cord-285262-690kpupt	40	4	(	(	-LRB-
cord-285262-690kpupt	40	5	for	for	IN
cord-285262-690kpupt	40	6	instance	instance	NN
cord-285262-690kpupt	40	7	caspase-8	caspase-8	NNP
cord-285262-690kpupt	40	8	and	and	CC
cord-285262-690kpupt	40	9	-9	-9	NNP
cord-285262-690kpupt	40	10	)	)	-RRB-
cord-285262-690kpupt	40	11	are	be	VBP
cord-285262-690kpupt	40	12	the	the	DT
cord-285262-690kpupt	40	13	upstream	upstream	JJ
cord-285262-690kpupt	40	14	components	component	NNS
cord-285262-690kpupt	40	15	of	of	IN
cord-285262-690kpupt	40	16	the	the	DT
cord-285262-690kpupt	40	17	caspase	caspase	NN
cord-285262-690kpupt	40	18	-	-	HYPH
cord-285262-690kpupt	40	19	cascade	cascade	NN
cord-285262-690kpupt	40	20	.	.	.
cord-285262-690kpupt	41	1	Their	-PRON-	PRP$
cord-285262-690kpupt	41	2	structurally	structurally	RB
cord-285262-690kpupt	41	3	unique	unique	JJ
cord-285262-690kpupt	41	4	feature	feature	NN
cord-285262-690kpupt	41	5	is	be	VBZ
cord-285262-690kpupt	41	6	the	the	DT
cord-285262-690kpupt	41	7	large	large	JJ
cord-285262-690kpupt	41	8	pro	pro	JJ
cord-285262-690kpupt	41	9	-	-	NN
cord-285262-690kpupt	41	10	domain	domain	NN
cord-285262-690kpupt	41	11	,	,	,
cord-285262-690kpupt	41	12	that	that	WDT
cord-285262-690kpupt	41	13	enables	enable	VBZ
cord-285262-690kpupt	41	14	the	the	DT
cord-285262-690kpupt	41	15	recruitment	recruitment	NN
cord-285262-690kpupt	41	16	to	to	IN
cord-285262-690kpupt	41	17	multimeric	multimeric	NNP
cord-285262-690kpupt	41	18	protein	protein	NN
cord-285262-690kpupt	41	19	complexes	complex	NNS
cord-285262-690kpupt	41	20	(	(	-LRB-
cord-285262-690kpupt	41	21	Mace	Mace	NNP
cord-285262-690kpupt	41	22	and	and	CC
cord-285262-690kpupt	41	23	Riedl	Riedl	NNP
cord-285262-690kpupt	41	24	,	,	,
cord-285262-690kpupt	41	25	2010	2010	CD
cord-285262-690kpupt	41	26	)	)	-RRB-
cord-285262-690kpupt	41	27	.	.	.
cord-285262-690kpupt	42	1	Extrinsic	extrinsic	JJ
cord-285262-690kpupt	42	2	and	and	CC
cord-285262-690kpupt	42	3	intrinsic	intrinsic	JJ
cord-285262-690kpupt	42	4	pathways	pathway	NNS
cord-285262-690kpupt	42	5	represent	represent	VBP
cord-285262-690kpupt	42	6	the	the	DT
cord-285262-690kpupt	42	7	two	two	CD
cord-285262-690kpupt	42	8	major	major	JJ
cord-285262-690kpupt	42	9	routes	route	NNS
cord-285262-690kpupt	42	10	of	of	IN
cord-285262-690kpupt	42	11	initiator	initiator	NN
cord-285262-690kpupt	42	12	caspase	caspase	NN
cord-285262-690kpupt	42	13	activation	activation	NN
cord-285262-690kpupt	42	14	.	.	.
cord-285262-690kpupt	43	1	In	in	IN
cord-285262-690kpupt	43	2	the	the	DT
cord-285262-690kpupt	43	3	extrinsic	extrinsic	JJ
cord-285262-690kpupt	43	4	pathway	pathway	NN
cord-285262-690kpupt	43	5	,	,	,
cord-285262-690kpupt	43	6	extracellular	extracellular	JJ
cord-285262-690kpupt	43	7	ligands	ligand	NNS
cord-285262-690kpupt	43	8	from	from	IN
cord-285262-690kpupt	43	9	the	the	DT
cord-285262-690kpupt	43	10	tumor	tumor	NN
cord-285262-690kpupt	43	11	necrosis	necrosis	NN
cord-285262-690kpupt	43	12	factor	factor	NN
cord-285262-690kpupt	43	13	(	(	-LRB-
cord-285262-690kpupt	43	14	TNF	TNF	NNP
cord-285262-690kpupt	43	15	)	)	-RRB-
cord-285262-690kpupt	43	16	superfamily	superfamily	NN
cord-285262-690kpupt	43	17	interact	interact	VBP
cord-285262-690kpupt	43	18	with	with	IN
cord-285262-690kpupt	43	19	transmembrane	transmembrane	NNP
cord-285262-690kpupt	43	20	death	death	NN
cord-285262-690kpupt	43	21	receptors	receptor	NNS
cord-285262-690kpupt	43	22	(	(	-LRB-
cord-285262-690kpupt	43	23	DR	DR	NNP
cord-285262-690kpupt	43	24	)	)	-RRB-
cord-285262-690kpupt	43	25	of	of	IN
cord-285262-690kpupt	43	26	the	the	DT
cord-285262-690kpupt	43	27	TNF	TNF	NNP
cord-285262-690kpupt	43	28	superfamily	superfamily	NN
cord-285262-690kpupt	43	29	.	.	.
cord-285262-690kpupt	44	1	Consequently	consequently	RB
cord-285262-690kpupt	44	2	,	,	,
cord-285262-690kpupt	44	3	by	by	IN
cord-285262-690kpupt	44	4	the	the	DT
cord-285262-690kpupt	44	5	help	help	NN
cord-285262-690kpupt	44	6	of	of	IN
cord-285262-690kpupt	44	7	an	an	DT
cord-285262-690kpupt	44	8	adaptor	adaptor	NN
cord-285262-690kpupt	44	9	protein	protein	NN
cord-285262-690kpupt	44	10	,	,	,
cord-285262-690kpupt	44	11	caspase-8	caspase-8	NNP
cord-285262-690kpupt	44	12	and	and	CC
cord-285262-690kpupt	44	13	-10	-10	NNP
cord-285262-690kpupt	44	14	are	be	VBP
cord-285262-690kpupt	44	15	recruited	recruit	VBN
cord-285262-690kpupt	44	16	into	into	IN
cord-285262-690kpupt	44	17	the	the	DT
cord-285262-690kpupt	44	18	DR	DR	NNP
cord-285262-690kpupt	44	19	containing	contain	VBG
cord-285262-690kpupt	44	20	cell	cell	NN
cord-285262-690kpupt	44	21	death	death	NN
cord-285262-690kpupt	44	22	inducing	induce	VBG
cord-285262-690kpupt	44	23	signaling	signal	VBG
cord-285262-690kpupt	44	24	complex	complex	NN
cord-285262-690kpupt	44	25	(	(	-LRB-
cord-285262-690kpupt	44	26	DISC	disc	NN
cord-285262-690kpupt	44	27	)	)	-RRB-
cord-285262-690kpupt	44	28	,	,	,
cord-285262-690kpupt	44	29	which	which	WDT
cord-285262-690kpupt	44	30	leads	lead	VBZ
cord-285262-690kpupt	44	31	to	to	IN
cord-285262-690kpupt	44	32	proximity	proximity	NN
cord-285262-690kpupt	44	33	induced	induce	VBN
cord-285262-690kpupt	44	34	cleavage	cleavage	NN
cord-285262-690kpupt	44	35	and	and	CC
cord-285262-690kpupt	44	36	activation	activation	NN
cord-285262-690kpupt	44	37	of	of	IN
cord-285262-690kpupt	44	38	these	these	DT
cord-285262-690kpupt	44	39	initiator	initiator	NN
cord-285262-690kpupt	44	40	caspases	caspase	NNS
cord-285262-690kpupt	45	1	(	(	-LRB-
cord-285262-690kpupt	45	2	Wilson	Wilson	NNP
cord-285262-690kpupt	45	3	et	et	NNP
cord-285262-690kpupt	45	4	al	al	NNP
cord-285262-690kpupt	45	5	.	.	NNP
cord-285262-690kpupt	45	6	,	,	,
cord-285262-690kpupt	45	7	2009	2009	CD
cord-285262-690kpupt	45	8	)	)	-RRB-
cord-285262-690kpupt	45	9	.	.	.
cord-285262-690kpupt	46	1	The	the	DT
cord-285262-690kpupt	46	2	intrinsic	intrinsic	JJ
cord-285262-690kpupt	46	3	pathway	pathway	NN
cord-285262-690kpupt	46	4	can	can	MD
cord-285262-690kpupt	46	5	be	be	VB
cord-285262-690kpupt	46	6	triggered	trigger	VBN
cord-285262-690kpupt	46	7	by	by	IN
cord-285262-690kpupt	46	8	intracellular	intracellular	JJ
cord-285262-690kpupt	46	9	perturbations	perturbation	NNS
cord-285262-690kpupt	46	10	,	,	,
cord-285262-690kpupt	46	11	for	for	IN
cord-285262-690kpupt	46	12	instance	instance	NN
cord-285262-690kpupt	46	13	by	by	IN
cord-285262-690kpupt	46	14	genotoxic	genotoxic	JJ
cord-285262-690kpupt	46	15	stress	stress	NN
cord-285262-690kpupt	46	16	,	,	,
cord-285262-690kpupt	46	17	starvation	starvation	NN
cord-285262-690kpupt	46	18	and	and	CC
cord-285262-690kpupt	46	19	ER	er	NN
cord-285262-690kpupt	46	20	-	-	HYPH
cord-285262-690kpupt	46	21	stress	stress	NN
cord-285262-690kpupt	46	22	.	.	.
cord-285262-690kpupt	47	1	Upon	upon	IN
cord-285262-690kpupt	47	2	stimulus	stimulus	NN
cord-285262-690kpupt	47	3	,	,	,
cord-285262-690kpupt	47	4	two	two	CD
cord-285262-690kpupt	47	5	pro	pro	JJ
cord-285262-690kpupt	47	6	-	-	JJ
cord-285262-690kpupt	47	7	apoptotic	apoptotic	JJ
cord-285262-690kpupt	47	8	members	member	NNS
cord-285262-690kpupt	47	9	of	of	IN
cord-285262-690kpupt	47	10	the	the	DT
cord-285262-690kpupt	47	11	B	B	NNP
cord-285262-690kpupt	47	12	cell	cell	NN
cord-285262-690kpupt	47	13	lymphoma	lymphoma	NN
cord-285262-690kpupt	47	14	2	2	CD
cord-285262-690kpupt	48	1	(	(	-LRB-
cord-285262-690kpupt	48	2	BCL-2	BCL-2	NNP
cord-285262-690kpupt	48	3	)	)	-RRB-
cord-285262-690kpupt	48	4	protein	protein	NNP
cord-285262-690kpupt	48	5	family	family	NN
cord-285262-690kpupt	48	6	BCL-2-associated	BCL-2-associated	NNP
cord-285262-690kpupt	48	7	X	X	NNP
cord-285262-690kpupt	48	8	protein	protein	NN
cord-285262-690kpupt	48	9	(	(	-LRB-
cord-285262-690kpupt	48	10	BAX	BAX	NNP
cord-285262-690kpupt	48	11	)	)	-RRB-
cord-285262-690kpupt	48	12	and	and	CC
cord-285262-690kpupt	48	13	BCL-2-antagonistic	bcl-2-antagonistic	JJ
cord-285262-690kpupt	48	14	killer	killer	NN
cord-285262-690kpupt	48	15	(	(	-LRB-
cord-285262-690kpupt	48	16	BAK	BAK	NNP
cord-285262-690kpupt	48	17	)	)	-RRB-
cord-285262-690kpupt	48	18	go	go	VB
cord-285262-690kpupt	48	19	through	through	IN
cord-285262-690kpupt	48	20	conformational	conformational	JJ
cord-285262-690kpupt	48	21	changes	change	NNS
cord-285262-690kpupt	48	22	and	and	CC
cord-285262-690kpupt	48	23	translocate	translocate	VB
cord-285262-690kpupt	48	24	into	into	IN
cord-285262-690kpupt	48	25	the	the	DT
cord-285262-690kpupt	48	26	mitochondria	mitochondrion	NNS
cord-285262-690kpupt	48	27	(	(	-LRB-
cord-285262-690kpupt	48	28	Tait	Tait	NNP
cord-285262-690kpupt	48	29	and	and	CC
cord-285262-690kpupt	48	30	Green	Green	NNP
cord-285262-690kpupt	48	31	,	,	,
cord-285262-690kpupt	48	32	2010	2010	CD
cord-285262-690kpupt	48	33	)	)	-RRB-
cord-285262-690kpupt	48	34	.	.	.
cord-285262-690kpupt	49	1	In	in	IN
cord-285262-690kpupt	49	2	turn	turn	NN
cord-285262-690kpupt	49	3	,	,	,
cord-285262-690kpupt	49	4	these	these	DT
cord-285262-690kpupt	49	5	proteins	protein	NNS
cord-285262-690kpupt	49	6	oligomerize	oligomerize	NNP
cord-285262-690kpupt	49	7	and	and	CC
cord-285262-690kpupt	49	8	form	form	VB
cord-285262-690kpupt	49	9	large	large	JJ
cord-285262-690kpupt	49	10	pores	pore	NNS
cord-285262-690kpupt	49	11	throughout	throughout	IN
cord-285262-690kpupt	49	12	the	the	DT
cord-285262-690kpupt	49	13	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	49	14	membrane	membrane	NN
cord-285262-690kpupt	49	15	(	(	-LRB-
cord-285262-690kpupt	49	16	Große	Große	NNP
cord-285262-690kpupt	49	17	et	et	FW
cord-285262-690kpupt	49	18	al	al	NNP
cord-285262-690kpupt	49	19	.	.	NNP
cord-285262-690kpupt	49	20	,	,	,
cord-285262-690kpupt	49	21	2016	2016	CD
cord-285262-690kpupt	49	22	)	)	-RRB-
cord-285262-690kpupt	49	23	.	.	.
cord-285262-690kpupt	50	1	This	this	DT
cord-285262-690kpupt	50	2	event	event	NN
cord-285262-690kpupt	50	3	initiates	initiate	VBZ
cord-285262-690kpupt	50	4	the	the	DT
cord-285262-690kpupt	50	5	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	50	6	outer	outer	JJ
cord-285262-690kpupt	50	7	membrane	membrane	NN
cord-285262-690kpupt	50	8	permeabilization	permeabilization	NN
cord-285262-690kpupt	50	9	(	(	-LRB-
cord-285262-690kpupt	50	10	MOMP	MOMP	NNP
cord-285262-690kpupt	50	11	)	)	-RRB-
cord-285262-690kpupt	50	12	.	.	.
cord-285262-690kpupt	51	1	Caspase-9	Caspase-9	NNP
cord-285262-690kpupt	51	2	activation	activation	NN
cord-285262-690kpupt	51	3	takes	take	VBZ
cord-285262-690kpupt	51	4	place	place	NN
cord-285262-690kpupt	51	5	in	in	IN
cord-285262-690kpupt	51	6	the	the	DT
cord-285262-690kpupt	51	7	apoptosome	apoptosome	NN
cord-285262-690kpupt	51	8	protein	protein	NN
cord-285262-690kpupt	51	9	complex	complex	NN
cord-285262-690kpupt	51	10	.	.	.
cord-285262-690kpupt	52	1	Formation	formation	NN
cord-285262-690kpupt	52	2	of	of	IN
cord-285262-690kpupt	52	3	this	this	DT
cord-285262-690kpupt	52	4	complex	complex	NN
cord-285262-690kpupt	52	5	is	be	VBZ
cord-285262-690kpupt	52	6	dependent	dependent	JJ
cord-285262-690kpupt	52	7	on	on	IN
cord-285262-690kpupt	52	8	the	the	DT
cord-285262-690kpupt	52	9	MOMP	MOMP	NNP
cord-285262-690kpupt	52	10	-	-	HYPH
cord-285262-690kpupt	52	11	driven	drive	VBN
cord-285262-690kpupt	52	12	release	release	NN
cord-285262-690kpupt	52	13	of	of	IN
cord-285262-690kpupt	52	14	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	52	15	proapoptotic	proapoptotic	JJ
cord-285262-690kpupt	52	16	proteins	protein	NNS
cord-285262-690kpupt	52	17	,	,	,
cord-285262-690kpupt	52	18	such	such	JJ
cord-285262-690kpupt	52	19	as	as	IN
cord-285262-690kpupt	52	20	cytochrome	cytochrome	NN
cord-285262-690kpupt	52	21	-	-	HYPH
cord-285262-690kpupt	52	22	C	c	NN
cord-285262-690kpupt	52	23	(	(	-LRB-
cord-285262-690kpupt	52	24	Riedl	Riedl	NNP
cord-285262-690kpupt	52	25	and	and	CC
cord-285262-690kpupt	52	26	Salvesen	Salvesen	NNP
cord-285262-690kpupt	52	27	,	,	,
cord-285262-690kpupt	52	28	2007	2007	CD
cord-285262-690kpupt	52	29	)	)	-RRB-
cord-285262-690kpupt	52	30	.	.	.
cord-285262-690kpupt	53	1	The	the	DT
cord-285262-690kpupt	53	2	activation	activation	NN
cord-285262-690kpupt	53	3	of	of	IN
cord-285262-690kpupt	53	4	initiator	initiator	NN
cord-285262-690kpupt	53	5	caspases	caspase	NNS
cord-285262-690kpupt	53	6	in	in	IN
cord-285262-690kpupt	53	7	both	both	DT
cord-285262-690kpupt	53	8	pathways	pathway	NNS
cord-285262-690kpupt	53	9	culminates	culminate	VBZ
cord-285262-690kpupt	53	10	in	in	IN
cord-285262-690kpupt	53	11	the	the	DT
cord-285262-690kpupt	53	12	cleavage	cleavage	NN
cord-285262-690kpupt	53	13	of	of	IN
cord-285262-690kpupt	53	14	executioner	executioner	NN
cord-285262-690kpupt	53	15	caspase-3	caspase-3	NNP
cord-285262-690kpupt	53	16	,	,	,
cord-285262-690kpupt	53	17	-6	-6	ADD
cord-285262-690kpupt	54	1	and	and	CC
cord-285262-690kpupt	54	2	-7	-7	NNP
cord-285262-690kpupt	54	3	.	.	.
cord-285262-690kpupt	55	1	In	in	IN
cord-285262-690kpupt	55	2	turn	turn	NN
cord-285262-690kpupt	55	3	,	,	,
cord-285262-690kpupt	55	4	the	the	DT
cord-285262-690kpupt	55	5	effector	effector	NN
cord-285262-690kpupt	55	6	caspases	caspase	NNS
cord-285262-690kpupt	55	7	cleave	cleave	VBP
cord-285262-690kpupt	55	8	selective	selective	JJ
cord-285262-690kpupt	55	9	substrates	substrate	NNS
cord-285262-690kpupt	55	10	,	,	,
cord-285262-690kpupt	55	11	including	include	VBG
cord-285262-690kpupt	55	12	poly	poly	JJ
cord-285262-690kpupt	55	13	ADP	ADP	NNP
cord-285262-690kpupt	55	14	-	-	HYPH
cord-285262-690kpupt	55	15	ribose	ribose	NN
cord-285262-690kpupt	55	16	polymerase	polymerase	NN
cord-285262-690kpupt	55	17	(	(	-LRB-
cord-285262-690kpupt	55	18	PARP	PARP	NNP
cord-285262-690kpupt	55	19	)	)	-RRB-
cord-285262-690kpupt	55	20	,	,	,
cord-285262-690kpupt	55	21	inhibitor	inhibitor	NN
cord-285262-690kpupt	55	22	of	of	IN
cord-285262-690kpupt	55	23	caspase	caspase	NN
cord-285262-690kpupt	55	24	activated	activate	VBN
cord-285262-690kpupt	55	25	DNAse	DNAse	NNP
cord-285262-690kpupt	55	26	(	(	-LRB-
cord-285262-690kpupt	55	27	ICAD	ICAD	NNP
cord-285262-690kpupt	55	28	)	)	-RRB-
cord-285262-690kpupt	55	29	and	and	CC
cord-285262-690kpupt	55	30	lamins	lamin	NNS
cord-285262-690kpupt	55	31	calling	call	VBG
cord-285262-690kpupt	55	32	forth	forth	RP
cord-285262-690kpupt	55	33	the	the	DT
cord-285262-690kpupt	55	34	biochemical	biochemical	JJ
cord-285262-690kpupt	55	35	and	and	CC
cord-285262-690kpupt	55	36	morphological	morphological	JJ
cord-285262-690kpupt	55	37	features	feature	NNS
cord-285262-690kpupt	55	38	of	of	IN
cord-285262-690kpupt	55	39	apoptosis	apoptosis	NN
cord-285262-690kpupt	55	40	(	(	-LRB-
cord-285262-690kpupt	55	41	Cohen	Cohen	NNP
cord-285262-690kpupt	55	42	,	,	,
cord-285262-690kpupt	55	43	1997	1997	CD
cord-285262-690kpupt	55	44	;	;	:
cord-285262-690kpupt	55	45	Tewari	Tewari	NNP
cord-285262-690kpupt	55	46	et	et	NNP
cord-285262-690kpupt	55	47	al	al	NNP
cord-285262-690kpupt	55	48	.	.	NNP
cord-285262-690kpupt	55	49	,	,	,
cord-285262-690kpupt	55	50	1995	1995	CD
cord-285262-690kpupt	55	51	)	)	-RRB-
cord-285262-690kpupt	55	52	.	.	.
cord-285262-690kpupt	56	1	Viruses	virus	NNS
cord-285262-690kpupt	56	2	are	be	VBP
cord-285262-690kpupt	56	3	obligatory	obligatory	JJ
cord-285262-690kpupt	56	4	intracellular	intracellular	JJ
cord-285262-690kpupt	56	5	pathogens	pathogen	NNS
cord-285262-690kpupt	56	6	and	and	CC
cord-285262-690kpupt	56	7	their	-PRON-	PRP$
cord-285262-690kpupt	56	8	propagation	propagation	NN
cord-285262-690kpupt	56	9	is	be	VBZ
cord-285262-690kpupt	56	10	fully	fully	RB
cord-285262-690kpupt	56	11	dependent	dependent	JJ
cord-285262-690kpupt	56	12	on	on	IN
cord-285262-690kpupt	56	13	the	the	DT
cord-285262-690kpupt	56	14	intracellular	intracellular	JJ
cord-285262-690kpupt	56	15	milieu	milieu	NN
cord-285262-690kpupt	56	16	of	of	IN
cord-285262-690kpupt	56	17	the	the	DT
cord-285262-690kpupt	56	18	host	host	NN
cord-285262-690kpupt	56	19	cell	cell	NN
cord-285262-690kpupt	56	20	.	.	.
cord-285262-690kpupt	57	1	The	the	DT
cord-285262-690kpupt	57	2	host	host	NN
cord-285262-690kpupt	57	3	organisms	organism	NNS
cord-285262-690kpupt	57	4	developed	develop	VBD
cord-285262-690kpupt	57	5	various	various	JJ
cord-285262-690kpupt	57	6	strategies	strategy	NNS
cord-285262-690kpupt	57	7	to	to	TO
cord-285262-690kpupt	57	8	detect	detect	VB
cord-285262-690kpupt	57	9	and	and	CC
cord-285262-690kpupt	57	10	destroy	destroy	VB
cord-285262-690kpupt	57	11	the	the	DT
cord-285262-690kpupt	57	12	invading	invade	VBG
cord-285262-690kpupt	57	13	viral	viral	JJ
cord-285262-690kpupt	57	14	pathogens	pathogen	NNS
cord-285262-690kpupt	57	15	.	.	.
cord-285262-690kpupt	58	1	The	the	DT
cord-285262-690kpupt	58	2	immunological	immunological	JJ
cord-285262-690kpupt	58	3	responses	response	NNS
cord-285262-690kpupt	58	4	,	,	,
cord-285262-690kpupt	58	5	involving	involve	VBG
cord-285262-690kpupt	58	6	the	the	DT
cord-285262-690kpupt	58	7	transcription	transcription	NN
cord-285262-690kpupt	58	8	of	of	IN
cord-285262-690kpupt	58	9	anti	anti	JJ
cord-285262-690kpupt	58	10	-	-	JJ
cord-285262-690kpupt	58	11	viral	viral	JJ
cord-285262-690kpupt	58	12	genes	gene	NNS
cord-285262-690kpupt	58	13	(	(	-LRB-
cord-285262-690kpupt	58	14	e.g.	e.g.	RB
cord-285262-690kpupt	58	15	,	,	,
cord-285262-690kpupt	58	16	interferons	interferon	NNS
cord-285262-690kpupt	58	17	and	and	CC
cord-285262-690kpupt	58	18	cytokines	cytokine	NNS
cord-285262-690kpupt	58	19	)	)	-RRB-
cord-285262-690kpupt	58	20	given	give	VBN
cord-285262-690kpupt	58	21	to	to	IN
cord-285262-690kpupt	58	22	a	a	DT
cord-285262-690kpupt	58	23	specific	specific	JJ
cord-285262-690kpupt	58	24	virus	virus	NN
cord-285262-690kpupt	58	25	infection	infection	NN
cord-285262-690kpupt	58	26	are	be	VBP
cord-285262-690kpupt	58	27	well	well	RB
cord-285262-690kpupt	58	28	characterized	characterize	VBN
cord-285262-690kpupt	58	29	.	.	.
cord-285262-690kpupt	59	1	It	-PRON-	PRP
cord-285262-690kpupt	59	2	is	be	VBZ
cord-285262-690kpupt	59	3	widely	widely	RB
cord-285262-690kpupt	59	4	accepted	accept	VBN
cord-285262-690kpupt	59	5	view	view	NN
cord-285262-690kpupt	59	6	that	that	IN
cord-285262-690kpupt	59	7	apoptosis	apoptosis	NN
cord-285262-690kpupt	59	8	can	can	MD
cord-285262-690kpupt	59	9	be	be	VB
cord-285262-690kpupt	59	10	beneficial	beneficial	JJ
cord-285262-690kpupt	59	11	for	for	IN
cord-285262-690kpupt	59	12	the	the	DT
cord-285262-690kpupt	59	13	host	host	NN
cord-285262-690kpupt	59	14	by	by	IN
cord-285262-690kpupt	59	15	destroying	destroy	VBG
cord-285262-690kpupt	59	16	the	the	DT
cord-285262-690kpupt	59	17	intracellular	intracellular	JJ
cord-285262-690kpupt	59	18	niche	niche	NN
cord-285262-690kpupt	59	19	of	of	IN
cord-285262-690kpupt	59	20	the	the	DT
cord-285262-690kpupt	59	21	pathogen	pathogen	NN
cord-285262-690kpupt	60	1	(	(	-LRB-
cord-285262-690kpupt	60	2	Evavold	Evavold	NNP
cord-285262-690kpupt	60	3	et	et	NNP
cord-285262-690kpupt	60	4	al	al	NNP
cord-285262-690kpupt	60	5	.	.	NNP
cord-285262-690kpupt	60	6	,	,	,
cord-285262-690kpupt	60	7	2018	2018	CD
cord-285262-690kpupt	60	8	)	)	-RRB-
cord-285262-690kpupt	60	9	.	.	.
cord-285262-690kpupt	61	1	The	the	DT
cord-285262-690kpupt	61	2	most	most	RBS
cord-285262-690kpupt	61	3	striking	striking	JJ
cord-285262-690kpupt	61	4	evidence	evidence	NN
cord-285262-690kpupt	61	5	for	for	IN
cord-285262-690kpupt	61	6	the	the	DT
cord-285262-690kpupt	61	7	anti	anti	JJ
cord-285262-690kpupt	61	8	-	-	JJ
cord-285262-690kpupt	61	9	viral	viral	JJ
cord-285262-690kpupt	61	10	advantage	advantage	NN
cord-285262-690kpupt	61	11	of	of	IN
cord-285262-690kpupt	61	12	apoptosis	apoptosis	NN
cord-285262-690kpupt	61	13	is	be	VBZ
cord-285262-690kpupt	61	14	the	the	DT
cord-285262-690kpupt	61	15	observation	observation	NN
cord-285262-690kpupt	61	16	that	that	IN
cord-285262-690kpupt	61	17	many	many	JJ
cord-285262-690kpupt	61	18	viruses	virus	NNS
cord-285262-690kpupt	61	19	produce	produce	VBP
cord-285262-690kpupt	61	20	anti	anti	JJ
cord-285262-690kpupt	61	21	-	-	JJ
cord-285262-690kpupt	61	22	apoptotic/	apoptotic/	JJ
cord-285262-690kpupt	61	23	necroptotic	necroptotic	JJ
cord-285262-690kpupt	61	24	proteins	protein	NNS
cord-285262-690kpupt	61	25	that	that	WDT
cord-285262-690kpupt	61	26	block	block	VBP
cord-285262-690kpupt	61	27	cell	cell	NN
cord-285262-690kpupt	61	28	death	death	NN
cord-285262-690kpupt	61	29	signals	signal	NNS
cord-285262-690kpupt	62	1	(	(	-LRB-
cord-285262-690kpupt	62	2	Thome	Thome	NNP
cord-285262-690kpupt	62	3	et	et	NNP
cord-285262-690kpupt	62	4	al	al	NNP
cord-285262-690kpupt	62	5	.	.	NNP
cord-285262-690kpupt	62	6	,	,	,
cord-285262-690kpupt	62	7	1997	1997	CD
cord-285262-690kpupt	62	8	;	;	:
cord-285262-690kpupt	62	9	Zhou	Zhou	NNP
cord-285262-690kpupt	62	10	et	et	NNP
cord-285262-690kpupt	62	11	al	al	NNP
cord-285262-690kpupt	62	12	.	.	NNP
cord-285262-690kpupt	62	13	,	,	,
cord-285262-690kpupt	62	14	1997	1997	CD
cord-285262-690kpupt	62	15	)	)	-RRB-
cord-285262-690kpupt	62	16	.	.	.
cord-285262-690kpupt	63	1	However	however	RB
cord-285262-690kpupt	63	2	,	,	,
cord-285262-690kpupt	63	3	based	base	VBN
cord-285262-690kpupt	63	4	on	on	IN
cord-285262-690kpupt	63	5	recent	recent	JJ
cord-285262-690kpupt	63	6	studies	study	NNS
cord-285262-690kpupt	63	7	,	,	,
cord-285262-690kpupt	63	8	it	-PRON-	PRP
cord-285262-690kpupt	63	9	is	be	VBZ
cord-285262-690kpupt	63	10	obvious	obvious	JJ
cord-285262-690kpupt	63	11	that	that	IN
cord-285262-690kpupt	63	12	the	the	DT
cord-285262-690kpupt	63	13	picture	picture	NN
cord-285262-690kpupt	63	14	is	be	VBZ
cord-285262-690kpupt	63	15	more	more	RBR
cord-285262-690kpupt	63	16	complex	complex	JJ
cord-285262-690kpupt	63	17	than	than	IN
cord-285262-690kpupt	63	18	originally	originally	RB
cord-285262-690kpupt	63	19	expected	expect	VBN
cord-285262-690kpupt	63	20	,	,	,
cord-285262-690kpupt	63	21	and	and	CC
cord-285262-690kpupt	63	22	whether	whether	IN
cord-285262-690kpupt	63	23	the	the	DT
cord-285262-690kpupt	63	24	cell	cell	NN
cord-285262-690kpupt	63	25	death	death	NN
cord-285262-690kpupt	63	26	is	be	VBZ
cord-285262-690kpupt	63	27	beneficial	beneficial	JJ
cord-285262-690kpupt	63	28	or	or	CC
cord-285262-690kpupt	63	29	detrimental	detrimental	JJ
cord-285262-690kpupt	63	30	for	for	IN
cord-285262-690kpupt	63	31	the	the	DT
cord-285262-690kpupt	63	32	host	host	NN
cord-285262-690kpupt	63	33	seems	seem	VBZ
cord-285262-690kpupt	63	34	to	to	TO
cord-285262-690kpupt	63	35	be	be	VB
cord-285262-690kpupt	63	36	dependent	dependent	JJ
cord-285262-690kpupt	63	37	on	on	IN
cord-285262-690kpupt	63	38	multiple	multiple	JJ
cord-285262-690kpupt	63	39	factors	factor	NNS
cord-285262-690kpupt	63	40	,	,	,
cord-285262-690kpupt	63	41	including	include	VBG
cord-285262-690kpupt	63	42	timing	timing	NN
cord-285262-690kpupt	63	43	,	,	,
cord-285262-690kpupt	63	44	cell	cell	NN
cord-285262-690kpupt	63	45	type	type	NN
cord-285262-690kpupt	63	46	and	and	CC
cord-285262-690kpupt	63	47	the	the	DT
cord-285262-690kpupt	63	48	effectiveness	effectiveness	NN
cord-285262-690kpupt	63	49	of	of	IN
cord-285262-690kpupt	63	50	the	the	DT
cord-285262-690kpupt	63	51	cell	cell	NN
cord-285262-690kpupt	63	52	death	death	NN
cord-285262-690kpupt	63	53	modality	modality	NN
cord-285262-690kpupt	63	54	to	to	TO
cord-285262-690kpupt	63	55	trigger	trigger	VB
cord-285262-690kpupt	63	56	or	or	CC
cord-285262-690kpupt	63	57	suppress	suppress	VB
cord-285262-690kpupt	63	58	immune	immune	JJ
cord-285262-690kpupt	63	59	response	response	NN
cord-285262-690kpupt	63	60	.	.	.
cord-285262-690kpupt	64	1	The	the	DT
cord-285262-690kpupt	64	2	TNF	TNF	NNP
cord-285262-690kpupt	64	3	ligand	ligand	NN
cord-285262-690kpupt	64	4	superfamily	superfamily	NN
cord-285262-690kpupt	64	5	acts	act	VBZ
cord-285262-690kpupt	64	6	via	via	IN
cord-285262-690kpupt	64	7	transmembrane	transmembrane	NNP
cord-285262-690kpupt	64	8	TNF	TNF	NNP
cord-285262-690kpupt	64	9	receptors	receptor	NNS
cord-285262-690kpupt	64	10	.	.	.
cord-285262-690kpupt	65	1	Specific	specific	JJ
cord-285262-690kpupt	65	2	members	member	NNS
cord-285262-690kpupt	65	3	of	of	IN
cord-285262-690kpupt	65	4	these	these	DT
cord-285262-690kpupt	65	5	receptor	receptor	NN
cord-285262-690kpupt	65	6	family	family	NN
cord-285262-690kpupt	65	7	,	,	,
cord-285262-690kpupt	65	8	also	also	RB
cord-285262-690kpupt	65	9	called	call	VBD
cord-285262-690kpupt	65	10	death	death	NN
cord-285262-690kpupt	65	11	receptors	receptor	NNS
cord-285262-690kpupt	65	12	(	(	-LRB-
cord-285262-690kpupt	65	13	DR	DR	NNP
cord-285262-690kpupt	65	14	)	)	-RRB-
cord-285262-690kpupt	65	15	,	,	,
cord-285262-690kpupt	65	16	possess	possess	VBP
cord-285262-690kpupt	65	17	a	a	DT
cord-285262-690kpupt	65	18	cytoplasmic	cytoplasmic	JJ
cord-285262-690kpupt	65	19	80	80	CD
cord-285262-690kpupt	65	20	amino	amino	NN
cord-285262-690kpupt	65	21	acid	acid	NN
cord-285262-690kpupt	65	22	motif	motif	NN
cord-285262-690kpupt	65	23	,	,	,
cord-285262-690kpupt	65	24	termed	term	VBN
cord-285262-690kpupt	65	25	death	death	NN
cord-285262-690kpupt	65	26	effector	effector	NN
cord-285262-690kpupt	65	27	domain	domain	NN
cord-285262-690kpupt	65	28	.	.	.
cord-285262-690kpupt	66	1	These	these	DT
cord-285262-690kpupt	66	2	receptors	receptor	NNS
cord-285262-690kpupt	66	3	,	,	,
cord-285262-690kpupt	66	4	including	include	VBG
cord-285262-690kpupt	66	5	TNFR1	tnfr1	XX
cord-285262-690kpupt	66	6	,	,	,
cord-285262-690kpupt	66	7	first	first	JJ
cord-285262-690kpupt	66	8	apoptosis	apoptosis	NN
cord-285262-690kpupt	66	9	signal	signal	NN
cord-285262-690kpupt	66	10	(	(	-LRB-
cord-285262-690kpupt	66	11	FAS	FAS	NNP
cord-285262-690kpupt	66	12	,	,	,
cord-285262-690kpupt	66	13	also	also	RB
cord-285262-690kpupt	66	14	called	call	VBN
cord-285262-690kpupt	66	15	CD95	CD95	NNP
cord-285262-690kpupt	66	16	)	)	-RRB-
cord-285262-690kpupt	66	17	and	and	CC
cord-285262-690kpupt	66	18	the	the	DT
cord-285262-690kpupt	66	19	TNF	TNF	NNP
cord-285262-690kpupt	66	20	-	-	HYPH
cord-285262-690kpupt	66	21	related	relate	VBN
cord-285262-690kpupt	66	22	apoptosis	apoptosis	NN
cord-285262-690kpupt	66	23	-	-	HYPH
cord-285262-690kpupt	66	24	inducing	induce	VBG
cord-285262-690kpupt	66	25	ligand	ligand	NN
cord-285262-690kpupt	66	26	receptor-1/2	receptor-1/2	NN
cord-285262-690kpupt	67	1	(	(	-LRB-
cord-285262-690kpupt	67	2	TRAILR1/2	trailr1/2	NN
cord-285262-690kpupt	67	3	)	)	-RRB-
cord-285262-690kpupt	67	4	can	can	MD
cord-285262-690kpupt	67	5	unleash	unleash	VB
cord-285262-690kpupt	67	6	various	various	JJ
cord-285262-690kpupt	67	7	signaling	signal	VBG
cord-285262-690kpupt	67	8	pathways	pathway	NNS
cord-285262-690kpupt	67	9	,	,	,
cord-285262-690kpupt	67	10	such	such	JJ
cord-285262-690kpupt	67	11	as	as	IN
cord-285262-690kpupt	67	12	proliferation	proliferation	NN
cord-285262-690kpupt	67	13	,	,	,
cord-285262-690kpupt	67	14	survival	survival	NN
cord-285262-690kpupt	67	15	,	,	,
cord-285262-690kpupt	67	16	immune	immune	JJ
cord-285262-690kpupt	67	17	response	response	NN
cord-285262-690kpupt	67	18	and	and	CC
cord-285262-690kpupt	67	19	apoptosis	apoptosis	NN
cord-285262-690kpupt	67	20	(	(	-LRB-
cord-285262-690kpupt	67	21	Wilson	Wilson	NNP
cord-285262-690kpupt	67	22	et	et	NNP
cord-285262-690kpupt	67	23	al	al	NNP
cord-285262-690kpupt	67	24	.	.	NNP
cord-285262-690kpupt	67	25	,	,	,
cord-285262-690kpupt	67	26	2009	2009	CD
cord-285262-690kpupt	67	27	)	)	-RRB-
cord-285262-690kpupt	67	28	.	.	.
cord-285262-690kpupt	68	1	In	in	IN
cord-285262-690kpupt	68	2	response	response	NN
cord-285262-690kpupt	68	3	to	to	IN
cord-285262-690kpupt	68	4	ligand	ligand	NN
cord-285262-690kpupt	68	5	binding	binding	NN
cord-285262-690kpupt	68	6	,	,	,
cord-285262-690kpupt	68	7	the	the	DT
cord-285262-690kpupt	68	8	trimerized	trimerized	JJ
cord-285262-690kpupt	68	9	DRs	DRs	NNPS
cord-285262-690kpupt	68	10	can	can	MD
cord-285262-690kpupt	68	11	recruit	recruit	VB
cord-285262-690kpupt	68	12	one	one	CD
cord-285262-690kpupt	68	13	of	of	IN
cord-285262-690kpupt	68	14	the	the	DT
cord-285262-690kpupt	68	15	two	two	CD
cord-285262-690kpupt	68	16	death	death	NN
cord-285262-690kpupt	68	17	domain	domain	NN
cord-285262-690kpupt	68	18	(	(	-LRB-
cord-285262-690kpupt	68	19	DD	DD	NNP
cord-285262-690kpupt	68	20	)	)	-RRB-
cord-285262-690kpupt	68	21	containing	contain	VBG
cord-285262-690kpupt	68	22	adaptor	adaptor	NN
cord-285262-690kpupt	68	23	proteins	protein	NNS
cord-285262-690kpupt	68	24	:	:	:
cord-285262-690kpupt	69	1	TNFR	TNFR	NNP
cord-285262-690kpupt	69	2	associated	associate	VBD
cord-285262-690kpupt	69	3	DD	DD	NNP
cord-285262-690kpupt	69	4	(	(	-LRB-
cord-285262-690kpupt	69	5	TRADD	TRADD	NNP
cord-285262-690kpupt	69	6	)	)	-RRB-
cord-285262-690kpupt	69	7	or	or	CC
cord-285262-690kpupt	70	1	FAS	FAS	NNP
cord-285262-690kpupt	70	2	associated	associate	VBD
cord-285262-690kpupt	70	3	DD	DD	NNP
cord-285262-690kpupt	70	4	(	(	-LRB-
cord-285262-690kpupt	70	5	FADD	FADD	NNP
cord-285262-690kpupt	70	6	)	)	-RRB-
cord-285262-690kpupt	70	7	.	.	.
cord-285262-690kpupt	71	1	Recruitment	recruitment	NN
cord-285262-690kpupt	71	2	of	of	IN
cord-285262-690kpupt	71	3	TRADD	TRADD	NNP
cord-285262-690kpupt	71	4	leads	lead	VBZ
cord-285262-690kpupt	71	5	to	to	IN
cord-285262-690kpupt	71	6	the	the	DT
cord-285262-690kpupt	71	7	assembly	assembly	NN
cord-285262-690kpupt	71	8	of	of	IN
cord-285262-690kpupt	71	9	a	a	DT
cord-285262-690kpupt	71	10	complex	complex	JJ
cord-285262-690kpupt	71	11	containing	contain	VBG
cord-285262-690kpupt	71	12	several	several	JJ
cord-285262-690kpupt	71	13	proteins	protein	NNS
cord-285262-690kpupt	71	14	,	,	,
cord-285262-690kpupt	71	15	including	include	VBG
cord-285262-690kpupt	71	16	the	the	DT
cord-285262-690kpupt	71	17	DD	DD	NNP
cord-285262-690kpupt	71	18	containing	contain	VBG
cord-285262-690kpupt	71	19	receptor	receptor	NN
cord-285262-690kpupt	71	20	interacting	interact	VBG
cord-285262-690kpupt	71	21	protein	protein	NN
cord-285262-690kpupt	71	22	kinase-1	kinase-1	NNP
cord-285262-690kpupt	71	23	(	(	-LRB-
cord-285262-690kpupt	71	24	RIPK1	RIPK1	NNP
cord-285262-690kpupt	71	25	)	)	-RRB-
cord-285262-690kpupt	72	1	(	(	-LRB-
cord-285262-690kpupt	72	2	Hsu	Hsu	NNP
cord-285262-690kpupt	72	3	et	et	NNP
cord-285262-690kpupt	72	4	al	al	NNP
cord-285262-690kpupt	72	5	.	.	NNP
cord-285262-690kpupt	72	6	,	,	,
cord-285262-690kpupt	72	7	1996	1996	CD
cord-285262-690kpupt	72	8	)	)	-RRB-
cord-285262-690kpupt	72	9	,	,	,
cord-285262-690kpupt	72	10	the	the	DT
cord-285262-690kpupt	72	11	cellular	cellular	JJ
cord-285262-690kpupt	72	12	FLICE	FLICE	NNP
cord-285262-690kpupt	72	13	/	/	SYM
cord-285262-690kpupt	72	14	Casp8	Casp8	VBD
cord-285262-690kpupt	72	15	inhibitory	inhibitory	JJ
cord-285262-690kpupt	72	16	protein	protein	NN
cord-285262-690kpupt	72	17	(	(	-LRB-
cord-285262-690kpupt	72	18	cFLIP	cFLIP	NNP
cord-285262-690kpupt	72	19	)	)	-RRB-
cord-285262-690kpupt	73	1	,	,	,
cord-285262-690kpupt	73	2	the	the	DT
cord-285262-690kpupt	73	3	TNFR	TNFR	NNP
cord-285262-690kpupt	73	4	associated	associate	VBD
cord-285262-690kpupt	73	5	factor-2	factor-2	NNP
cord-285262-690kpupt	73	6	(	(	-LRB-
cord-285262-690kpupt	73	7	TRAF2	TRAF2	NNP
cord-285262-690kpupt	73	8	)	)	-RRB-
cord-285262-690kpupt	73	9	and	and	CC
cord-285262-690kpupt	73	10	the	the	DT
cord-285262-690kpupt	73	11	E3	e3	NN
cord-285262-690kpupt	73	12	ubiquitin	ubiquitin	NN
cord-285262-690kpupt	73	13	ligase	ligase	NN
cord-285262-690kpupt	73	14	cellular	cellular	JJ
cord-285262-690kpupt	73	15	inhibitor	inhibitor	NN
cord-285262-690kpupt	73	16	of	of	IN
cord-285262-690kpupt	73	17	apoptosis	apoptosis	NN
cord-285262-690kpupt	73	18	(	(	-LRB-
cord-285262-690kpupt	73	19	cIAP	ciap	NN
cord-285262-690kpupt	73	20	)	)	-RRB-
cord-285262-690kpupt	74	1	(	(	-LRB-
cord-285262-690kpupt	74	2	Varfolomeev	Varfolomeev	NNP
cord-285262-690kpupt	74	3	and	and	CC
cord-285262-690kpupt	74	4	Vucic	Vucic	NNP
cord-285262-690kpupt	74	5	,	,	,
cord-285262-690kpupt	74	6	2008	2008	CD
cord-285262-690kpupt	74	7	)	)	-RRB-
cord-285262-690kpupt	74	8	.	.	.
cord-285262-690kpupt	75	1	This	this	DT
cord-285262-690kpupt	75	2	protein	protein	NN
cord-285262-690kpupt	75	3	complex	complex	NN
cord-285262-690kpupt	75	4	conveys	convey	VBZ
cord-285262-690kpupt	75	5	a	a	DT
cord-285262-690kpupt	75	6	non	non	JJ
cord-285262-690kpupt	75	7	-	-	JJ
cord-285262-690kpupt	75	8	apoptotic	apoptotic	JJ
cord-285262-690kpupt	75	9	signal	signal	NN
cord-285262-690kpupt	75	10	via	via	IN
cord-285262-690kpupt	75	11	the	the	DT
cord-285262-690kpupt	75	12	activation	activation	NN
cord-285262-690kpupt	75	13	of	of	IN
cord-285262-690kpupt	75	14	the	the	DT
cord-285262-690kpupt	75	15	NF	nf	NN
cord-285262-690kpupt	75	16	-	-	HYPH
cord-285262-690kpupt	75	17	κB	κB	NNP
cord-285262-690kpupt	75	18	signaling	signaling	NN
cord-285262-690kpupt	75	19	.	.	.
cord-285262-690kpupt	76	1	In	in	IN
cord-285262-690kpupt	76	2	contrast	contrast	NN
cord-285262-690kpupt	76	3	,	,	,
cord-285262-690kpupt	76	4	the	the	DT
cord-285262-690kpupt	76	5	binding	binding	NN
cord-285262-690kpupt	76	6	of	of	IN
cord-285262-690kpupt	76	7	FADD	FADD	NNP
cord-285262-690kpupt	76	8	triggers	trigger	VBZ
cord-285262-690kpupt	76	9	the	the	DT
cord-285262-690kpupt	76	10	interaction	interaction	NN
cord-285262-690kpupt	76	11	of	of	IN
cord-285262-690kpupt	76	12	caspase-8	caspase-8	NNP
cord-285262-690kpupt	76	13	and	and	CC
cord-285262-690kpupt	76	14	-10	-10	NNP
cord-285262-690kpupt	76	15	,	,	,
cord-285262-690kpupt	76	16	leading	lead	VBG
cord-285262-690kpupt	76	17	to	to	IN
cord-285262-690kpupt	76	18	apoptotic	apoptotic	JJ
cord-285262-690kpupt	76	19	signaling	signaling	NN
cord-285262-690kpupt	76	20	either	either	CC
cord-285262-690kpupt	76	21	via	via	IN
cord-285262-690kpupt	76	22	the	the	DT
cord-285262-690kpupt	76	23	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	76	24	amplification	amplification	NN
cord-285262-690kpupt	76	25	loop	loop	NN
cord-285262-690kpupt	76	26	or	or	CC
cord-285262-690kpupt	76	27	via	via	IN
cord-285262-690kpupt	76	28	direct	direct	JJ
cord-285262-690kpupt	76	29	caspase-3/-7	caspase-3/-7	NNP
cord-285262-690kpupt	76	30	cleavage	cleavage	NN
cord-285262-690kpupt	76	31	in	in	IN
cord-285262-690kpupt	76	32	immune	immune	JJ
cord-285262-690kpupt	76	33	cells	cell	NNS
cord-285262-690kpupt	76	34	.	.	.
cord-285262-690kpupt	77	1	TNFR	TNFR	NNP
cord-285262-690kpupt	77	2	stimulation	stimulation	NN
cord-285262-690kpupt	77	3	primarily	primarily	RB
cord-285262-690kpupt	77	4	results	result	VBZ
cord-285262-690kpupt	77	5	in	in	IN
cord-285262-690kpupt	77	6	the	the	DT
cord-285262-690kpupt	77	7	recruitment	recruitment	NN
cord-285262-690kpupt	77	8	of	of	IN
cord-285262-690kpupt	77	9	TRADD	TRADD	NNP
cord-285262-690kpupt	77	10	,	,	,
cord-285262-690kpupt	77	11	leading	lead	VBG
cord-285262-690kpupt	77	12	to	to	IN
cord-285262-690kpupt	77	13	non	non	JJ
cord-285262-690kpupt	77	14	-	-	JJ
cord-285262-690kpupt	77	15	apoptotic	apoptotic	JJ
cord-285262-690kpupt	77	16	signals	signal	NNS
cord-285262-690kpupt	77	17	via	via	IN
cord-285262-690kpupt	77	18	NF	nf	NN
cord-285262-690kpupt	77	19	-	-	HYPH
cord-285262-690kpupt	77	20	κB	κb	CD
cord-285262-690kpupt	77	21	activation	activation	NN
cord-285262-690kpupt	77	22	and	and	CC
cord-285262-690kpupt	77	23	expression	expression	NN
cord-285262-690kpupt	77	24	of	of	IN
cord-285262-690kpupt	77	25	pro	pro	JJ
cord-285262-690kpupt	77	26	-	-	JJ
cord-285262-690kpupt	77	27	survival	survival	JJ
cord-285262-690kpupt	77	28	genes	gene	NNS
cord-285262-690kpupt	77	29	such	such	JJ
cord-285262-690kpupt	77	30	as	as	IN
cord-285262-690kpupt	77	31	cFLIP	cFLIP	NNP
cord-285262-690kpupt	77	32	.	.	.
cord-285262-690kpupt	78	1	Once	once	RB
cord-285262-690kpupt	78	2	this	this	DT
cord-285262-690kpupt	78	3	primary	primary	JJ
cord-285262-690kpupt	78	4	signal	signal	NN
cord-285262-690kpupt	78	5	is	be	VBZ
cord-285262-690kpupt	78	6	compromised	compromise	VBN
cord-285262-690kpupt	78	7	by	by	IN
cord-285262-690kpupt	78	8	the	the	DT
cord-285262-690kpupt	78	9	inhibition	inhibition	NN
cord-285262-690kpupt	78	10	of	of	IN
cord-285262-690kpupt	78	11	the	the	DT
cord-285262-690kpupt	78	12	expression	expression	NN
cord-285262-690kpupt	78	13	of	of	IN
cord-285262-690kpupt	78	14	anti	anti	JJ
cord-285262-690kpupt	78	15	-	-	JJ
cord-285262-690kpupt	78	16	apoptotic	apoptotic	JJ
cord-285262-690kpupt	78	17	cFLIP	cFLIP	NNP
cord-285262-690kpupt	78	18	,	,	,
cord-285262-690kpupt	78	19	the	the	DT
cord-285262-690kpupt	78	20	apoptotic	apoptotic	JJ
cord-285262-690kpupt	78	21	signal	signal	NN
cord-285262-690kpupt	78	22	can	can	MD
cord-285262-690kpupt	78	23	proceed	proceed	VB
cord-285262-690kpupt	78	24	.	.	.
cord-285262-690kpupt	79	1	Conversely	conversely	RB
cord-285262-690kpupt	79	2	,	,	,
cord-285262-690kpupt	79	3	activation	activation	NN
cord-285262-690kpupt	79	4	of	of	IN
cord-285262-690kpupt	79	5	FAS	FAS	NNP
cord-285262-690kpupt	79	6	and	and	CC
cord-285262-690kpupt	79	7	TRAILR	TRAILR	NNP
cord-285262-690kpupt	79	8	predominately	predominately	RB
cord-285262-690kpupt	79	9	transduces	transduce	VBZ
cord-285262-690kpupt	79	10	FADD	FADD	NNP
cord-285262-690kpupt	79	11	dependent	dependent	JJ
cord-285262-690kpupt	79	12	apoptotic	apoptotic	JJ
cord-285262-690kpupt	79	13	signaling	signal	VBG
cord-285262-690kpupt	79	14	(	(	-LRB-
cord-285262-690kpupt	79	15	Wilson	Wilson	NNP
cord-285262-690kpupt	79	16	et	et	NNP
cord-285262-690kpupt	79	17	al	al	NNP
cord-285262-690kpupt	79	18	.	.	NNP
cord-285262-690kpupt	79	19	,	,	,
cord-285262-690kpupt	79	20	2009	2009	CD
cord-285262-690kpupt	79	21	)	)	-RRB-
cord-285262-690kpupt	79	22	.	.	.
cord-285262-690kpupt	80	1	Signaling	signal	VBG
cord-285262-690kpupt	80	2	through	through	IN
cord-285262-690kpupt	80	3	DRs	dr	NNS
cord-285262-690kpupt	80	4	represents	represent	VBZ
cord-285262-690kpupt	80	5	one	one	CD
cord-285262-690kpupt	80	6	of	of	IN
cord-285262-690kpupt	80	7	the	the	DT
cord-285262-690kpupt	80	8	major	major	JJ
cord-285262-690kpupt	80	9	forms	form	NNS
cord-285262-690kpupt	80	10	of	of	IN
cord-285262-690kpupt	80	11	the	the	DT
cord-285262-690kpupt	80	12	immune	immune	JJ
cord-285262-690kpupt	80	13	cell	cell	NN
cord-285262-690kpupt	80	14	directed	direct	VBD
cord-285262-690kpupt	80	15	host	host	NN
cord-285262-690kpupt	80	16	cell	cell	NN
cord-285262-690kpupt	80	17	killing	kill	VBG
cord-285262-690kpupt	80	18	in	in	IN
cord-285262-690kpupt	80	19	infection	infection	NN
cord-285262-690kpupt	80	20	.	.	.
cord-285262-690kpupt	81	1	Cytotoxic	Cytotoxic	NNP
cord-285262-690kpupt	81	2	T	t	NN
cord-285262-690kpupt	81	3	cells	cell	NNS
cord-285262-690kpupt	81	4	(	(	-LRB-
cord-285262-690kpupt	81	5	CTL	CTL	NNP
cord-285262-690kpupt	81	6	)	)	-RRB-
cord-285262-690kpupt	81	7	are	be	VBP
cord-285262-690kpupt	81	8	key	key	JJ
cord-285262-690kpupt	81	9	components	component	NNS
cord-285262-690kpupt	81	10	of	of	IN
cord-285262-690kpupt	81	11	the	the	DT
cord-285262-690kpupt	81	12	adaptive	adaptive	JJ
cord-285262-690kpupt	81	13	immune	immune	JJ
cord-285262-690kpupt	81	14	response	response	NN
cord-285262-690kpupt	81	15	and	and	CC
cord-285262-690kpupt	82	1	natural	natural	JJ
cord-285262-690kpupt	82	2	killer	killer	NN
cord-285262-690kpupt	82	3	(	(	-LRB-
cord-285262-690kpupt	82	4	NK	NK	NNP
cord-285262-690kpupt	82	5	)	)	-RRB-
cord-285262-690kpupt	82	6	cells	cell	NNS
cord-285262-690kpupt	82	7	play	play	VBP
cord-285262-690kpupt	82	8	analogous	analogous	JJ
cord-285262-690kpupt	82	9	role	role	NN
cord-285262-690kpupt	82	10	in	in	IN
cord-285262-690kpupt	82	11	the	the	DT
cord-285262-690kpupt	82	12	innate	innate	JJ
cord-285262-690kpupt	82	13	immune	immune	JJ
cord-285262-690kpupt	82	14	response	response	NN
cord-285262-690kpupt	82	15	.	.	.
cord-285262-690kpupt	83	1	CTLs	CTLs	NNP
cord-285262-690kpupt	83	2	express	express	VBP
cord-285262-690kpupt	83	3	FAS	FAS	NNP
cord-285262-690kpupt	83	4	ligands	ligand	NNS
cord-285262-690kpupt	83	5	(	(	-LRB-
cord-285262-690kpupt	83	6	FASL	FASL	NNP
cord-285262-690kpupt	83	7	)	)	-RRB-
cord-285262-690kpupt	83	8	on	on	IN
cord-285262-690kpupt	83	9	their	-PRON-	PRP$
cord-285262-690kpupt	83	10	surface	surface	NN
cord-285262-690kpupt	84	1	(	(	-LRB-
cord-285262-690kpupt	84	2	Fig	Fig	NNP
cord-285262-690kpupt	84	3	.	.	NNP
cord-285262-690kpupt	84	4	1	1	CD
cord-285262-690kpupt	84	5	)	)	-RRB-
cord-285262-690kpupt	85	1	(	(	-LRB-
cord-285262-690kpupt	85	2	Halle	Halle	NNP
cord-285262-690kpupt	85	3	et	et	NNP
cord-285262-690kpupt	85	4	al	al	NNP
cord-285262-690kpupt	85	5	.	.	NNP
cord-285262-690kpupt	85	6	,	,	,
cord-285262-690kpupt	85	7	2017	2017	CD
cord-285262-690kpupt	85	8	)	)	-RRB-
cord-285262-690kpupt	85	9	.	.	.
cord-285262-690kpupt	86	1	The	the	DT
cord-285262-690kpupt	86	2	trimerized	trimerized	JJ
cord-285262-690kpupt	86	3	ligands	ligand	NNS
cord-285262-690kpupt	86	4	bind	bind	VBP
cord-285262-690kpupt	86	5	the	the	DT
cord-285262-690kpupt	86	6	DRs	DRs	NNPS
cord-285262-690kpupt	86	7	expressed	express	VBN
cord-285262-690kpupt	86	8	on	on	IN
cord-285262-690kpupt	86	9	the	the	DT
cord-285262-690kpupt	86	10	cell	cell	NN
cord-285262-690kpupt	86	11	surface	surface	NN
cord-285262-690kpupt	86	12	,	,	,
cord-285262-690kpupt	86	13	leading	lead	VBG
cord-285262-690kpupt	86	14	to	to	IN
cord-285262-690kpupt	86	15	DR	DR	NNP
cord-285262-690kpupt	86	16	clustering	clustering	NN
cord-285262-690kpupt	86	17	and	and	CC
cord-285262-690kpupt	86	18	binding	binding	NN
cord-285262-690kpupt	86	19	of	of	IN
cord-285262-690kpupt	86	20	the	the	DT
cord-285262-690kpupt	86	21	adaptor	adaptor	NN
cord-285262-690kpupt	86	22	protein	protein	NN
cord-285262-690kpupt	86	23	FADD	FADD	NNP
cord-285262-690kpupt	86	24	,	,	,
cord-285262-690kpupt	86	25	which	which	WDT
cord-285262-690kpupt	86	26	consequently	consequently	RB
cord-285262-690kpupt	86	27	results	result	VBZ
cord-285262-690kpupt	86	28	in	in	IN
cord-285262-690kpupt	86	29	the	the	DT
cord-285262-690kpupt	86	30	recruitment	recruitment	NN
cord-285262-690kpupt	86	31	of	of	IN
cord-285262-690kpupt	86	32	initiator	initiator	NN
cord-285262-690kpupt	86	33	caspase-8/-10	caspase-8/-10	NNP
cord-285262-690kpupt	86	34	.	.	.
cord-285262-690kpupt	87	1	This	this	DT
cord-285262-690kpupt	87	2	cell	cell	NN
cord-285262-690kpupt	87	3	killing	killing	NN
cord-285262-690kpupt	87	4	mechanism	mechanism	NN
cord-285262-690kpupt	87	5	can	can	MD
cord-285262-690kpupt	87	6	reduce	reduce	VB
cord-285262-690kpupt	87	7	the	the	DT
cord-285262-690kpupt	87	8	spreading	spreading	NN
cord-285262-690kpupt	87	9	of	of	IN
cord-285262-690kpupt	87	10	the	the	DT
cord-285262-690kpupt	87	11	virus	virus	NN
cord-285262-690kpupt	87	12	by	by	IN
cord-285262-690kpupt	87	13	eliminating	eliminate	VBG
cord-285262-690kpupt	87	14	the	the	DT
cord-285262-690kpupt	87	15	intracellular	intracellular	JJ
cord-285262-690kpupt	87	16	niche	niche	NN
cord-285262-690kpupt	87	17	of	of	IN
cord-285262-690kpupt	87	18	the	the	DT
cord-285262-690kpupt	87	19	pathogen	pathogen	NN
cord-285262-690kpupt	87	20	(	(	-LRB-
cord-285262-690kpupt	87	21	Halle	Halle	NNP
cord-285262-690kpupt	87	22	et	et	NNP
cord-285262-690kpupt	87	23	al	al	NNP
cord-285262-690kpupt	87	24	.	.	NNP
cord-285262-690kpupt	87	25	,	,	,
cord-285262-690kpupt	87	26	2017	2017	CD
cord-285262-690kpupt	87	27	)	)	-RRB-
cord-285262-690kpupt	87	28	.	.	.
cord-285262-690kpupt	88	1	This	this	DT
cord-285262-690kpupt	88	2	occurs	occur	VBZ
cord-285262-690kpupt	88	3	in	in	IN
cord-285262-690kpupt	88	4	human	human	JJ
cord-285262-690kpupt	88	5	vascular	vascular	JJ
cord-285262-690kpupt	88	6	endothelial	endothelial	JJ
cord-285262-690kpupt	88	7	cells	cell	NNS
cord-285262-690kpupt	88	8	in	in	IN
cord-285262-690kpupt	88	9	response	response	NN
cord-285262-690kpupt	88	10	to	to	IN
cord-285262-690kpupt	88	11	Dengue	dengue	NN
cord-285262-690kpupt	88	12	virus	virus	NN
cord-285262-690kpupt	88	13	(	(	-LRB-
cord-285262-690kpupt	88	14	DV	DV	NNP
cord-285262-690kpupt	88	15	)	)	-RRB-
cord-285262-690kpupt	88	16	,	,	,
cord-285262-690kpupt	88	17	where	where	WRB
cord-285262-690kpupt	88	18	the	the	DT
cord-285262-690kpupt	88	19	cells	cell	NNS
cord-285262-690kpupt	88	20	exhibit	exhibit	VBP
cord-285262-690kpupt	88	21	increased	increase	VBN
cord-285262-690kpupt	88	22	FASL	FASL	NNP
cord-285262-690kpupt	88	23	and	and	CC
cord-285262-690kpupt	88	24	FAS	FAS	NNP
cord-285262-690kpupt	88	25	expression	expression	NN
cord-285262-690kpupt	88	26	and	and	CC
cord-285262-690kpupt	88	27	increased	increase	VBN
cord-285262-690kpupt	88	28	number	number	NN
cord-285262-690kpupt	88	29	of	of	IN
cord-285262-690kpupt	88	30	FAS	FAS	NNP
cord-285262-690kpupt	88	31	on	on	IN
cord-285262-690kpupt	88	32	the	the	DT
cord-285262-690kpupt	88	33	cell	cell	NN
cord-285262-690kpupt	88	34	surface	surface	NN
cord-285262-690kpupt	88	35	.	.	.
cord-285262-690kpupt	89	1	This	this	DT
cord-285262-690kpupt	89	2	phenomenon	phenomenon	NN
cord-285262-690kpupt	89	3	is	be	VBZ
cord-285262-690kpupt	89	4	accompanied	accompany	VBN
cord-285262-690kpupt	89	5	by	by	IN
cord-285262-690kpupt	89	6	elevated	elevated	JJ
cord-285262-690kpupt	89	7	rate	rate	NN
cord-285262-690kpupt	89	8	of	of	IN
cord-285262-690kpupt	89	9	apoptosis	apoptosis	NN
cord-285262-690kpupt	89	10	(	(	-LRB-
cord-285262-690kpupt	89	11	Liao	Liao	NNP
cord-285262-690kpupt	89	12	et	et	FW
cord-285262-690kpupt	89	13	al	al	NNP
cord-285262-690kpupt	89	14	.	.	NNP
cord-285262-690kpupt	89	15	,	,	,
cord-285262-690kpupt	89	16	2010	2010	CD
cord-285262-690kpupt	89	17	)	)	-RRB-
cord-285262-690kpupt	89	18	.	.	.
cord-285262-690kpupt	90	1	Similarly	similarly	RB
cord-285262-690kpupt	90	2	,	,	,
cord-285262-690kpupt	90	3	influenza	influenza	NN
cord-285262-690kpupt	90	4	A	a	DT
cord-285262-690kpupt	90	5	virus	virus	NN
cord-285262-690kpupt	90	6	(	(	-LRB-
cord-285262-690kpupt	90	7	IAV	iav	NN
cord-285262-690kpupt	90	8	)	)	-RRB-
cord-285262-690kpupt	90	9	infection	infection	NN
cord-285262-690kpupt	90	10	leads	lead	VBZ
cord-285262-690kpupt	90	11	to	to	IN
cord-285262-690kpupt	90	12	the	the	DT
cord-285262-690kpupt	90	13	expression	expression	NN
cord-285262-690kpupt	90	14	of	of	IN
cord-285262-690kpupt	90	15	FASL	FASL	NNP
cord-285262-690kpupt	90	16	,	,	,
cord-285262-690kpupt	90	17	FADD	FADD	NNP
cord-285262-690kpupt	90	18	and	and	CC
cord-285262-690kpupt	90	19	caspase-8	caspase-8	NNP
cord-285262-690kpupt	90	20	,	,	,
cord-285262-690kpupt	90	21	and	and	CC
cord-285262-690kpupt	90	22	downregulates	downregulate	VBZ
cord-285262-690kpupt	90	23	the	the	DT
cord-285262-690kpupt	90	24	expression	expression	NN
cord-285262-690kpupt	90	25	of	of	IN
cord-285262-690kpupt	90	26	cFLIP	cFLIP	NNP
cord-285262-690kpupt	90	27	in	in	IN
cord-285262-690kpupt	90	28	human	human	JJ
cord-285262-690kpupt	90	29	lung	lung	NN
cord-285262-690kpupt	90	30	epithelial	epithelial	JJ
cord-285262-690kpupt	90	31	cell	cell	NN
cord-285262-690kpupt	90	32	lines	line	NNS
cord-285262-690kpupt	90	33	.	.	.
cord-285262-690kpupt	91	1	However	however	RB
cord-285262-690kpupt	91	2	,	,	,
cord-285262-690kpupt	91	3	it	-PRON-	PRP
cord-285262-690kpupt	91	4	is	be	VBZ
cord-285262-690kpupt	91	5	not	not	RB
cord-285262-690kpupt	91	6	entirely	entirely	RB
cord-285262-690kpupt	91	7	clear	clear	JJ
cord-285262-690kpupt	91	8	if	if	IN
cord-285262-690kpupt	91	9	the	the	DT
cord-285262-690kpupt	91	10	host	host	NN
cord-285262-690kpupt	91	11	or	or	CC
cord-285262-690kpupt	91	12	the	the	DT
cord-285262-690kpupt	91	13	virus	virus	NN
cord-285262-690kpupt	91	14	profits	profit	NNS
cord-285262-690kpupt	91	15	from	from	IN
cord-285262-690kpupt	91	16	the	the	DT
cord-285262-690kpupt	91	17	apoptosis	apoptosis	NN
cord-285262-690kpupt	91	18	induction	induction	NN
cord-285262-690kpupt	91	19	.	.	.
cord-285262-690kpupt	92	1	For	for	IN
cord-285262-690kpupt	92	2	instance	instance	NN
cord-285262-690kpupt	92	3	,	,	,
cord-285262-690kpupt	92	4	the	the	DT
cord-285262-690kpupt	92	5	replication	replication	NN
cord-285262-690kpupt	92	6	of	of	IN
cord-285262-690kpupt	92	7	the	the	DT
cord-285262-690kpupt	92	8	IAV	IAV	NNP
cord-285262-690kpupt	92	9	can	can	MD
cord-285262-690kpupt	92	10	be	be	VB
cord-285262-690kpupt	92	11	amplified	amplify	VBN
cord-285262-690kpupt	92	12	by	by	IN
cord-285262-690kpupt	92	13	overexpression	overexpression	NN
cord-285262-690kpupt	92	14	of	of	IN
cord-285262-690kpupt	92	15	proapoptotic	proapoptotic	JJ
cord-285262-690kpupt	92	16	genes	gene	NNS
cord-285262-690kpupt	92	17	and	and	CC
cord-285262-690kpupt	92	18	is	be	VBZ
cord-285262-690kpupt	92	19	blocked	block	VBN
cord-285262-690kpupt	92	20	by	by	IN
cord-285262-690kpupt	92	21	the	the	DT
cord-285262-690kpupt	92	22	upregulation	upregulation	NN
cord-285262-690kpupt	92	23	of	of	IN
cord-285262-690kpupt	92	24	anti	anti	JJ
cord-285262-690kpupt	92	25	-	-	JJ
cord-285262-690kpupt	92	26	apoptotic	apoptotic	JJ
cord-285262-690kpupt	92	27	genes	gene	NNS
cord-285262-690kpupt	92	28	.	.	.
cord-285262-690kpupt	93	1	This	this	DT
cord-285262-690kpupt	93	2	study	study	NN
cord-285262-690kpupt	93	3	suggests	suggest	VBZ
cord-285262-690kpupt	93	4	that	that	IN
cord-285262-690kpupt	93	5	an	an	DT
cord-285262-690kpupt	93	6	initially	initially	RB
cord-285262-690kpupt	93	7	protective	protective	JJ
cord-285262-690kpupt	93	8	apoptotic	apoptotic	JJ
cord-285262-690kpupt	93	9	over	over	IN
cord-285262-690kpupt	93	10	-	-	HYPH
cord-285262-690kpupt	93	11	activation	activation	NN
cord-285262-690kpupt	93	12	can	can	MD
cord-285262-690kpupt	93	13	turn	turn	VB
cord-285262-690kpupt	93	14	against	against	IN
cord-285262-690kpupt	93	15	the	the	DT
cord-285262-690kpupt	93	16	host	host	NN
cord-285262-690kpupt	93	17	in	in	IN
cord-285262-690kpupt	93	18	some	some	DT
cord-285262-690kpupt	93	19	instances	instance	NNS
cord-285262-690kpupt	93	20	.	.	.
cord-285262-690kpupt	94	1	TNFα	TNFα	NNP
cord-285262-690kpupt	94	2	,	,	,
cord-285262-690kpupt	94	3	the	the	DT
cord-285262-690kpupt	94	4	ligand	ligand	NN
cord-285262-690kpupt	94	5	of	of	IN
cord-285262-690kpupt	94	6	TNFR1	TNFR1	NNP
cord-285262-690kpupt	94	7	can	can	MD
cord-285262-690kpupt	94	8	also	also	RB
cord-285262-690kpupt	94	9	be	be	VB
cord-285262-690kpupt	94	10	expressed	express	VBN
cord-285262-690kpupt	94	11	paracrine	paracrine	JJ
cord-285262-690kpupt	94	12	or	or	CC
cord-285262-690kpupt	94	13	in	in	IN
cord-285262-690kpupt	94	14	autocrine	autocrine	JJ
cord-285262-690kpupt	94	15	manner	manner	NN
cord-285262-690kpupt	94	16	as	as	IN
cord-285262-690kpupt	94	17	the	the	DT
cord-285262-690kpupt	94	18	part	part	NN
cord-285262-690kpupt	94	19	of	of	IN
cord-285262-690kpupt	94	20	the	the	DT
cord-285262-690kpupt	94	21	anti	anti	JJ
cord-285262-690kpupt	94	22	-	-	JJ
cord-285262-690kpupt	94	23	viral	viral	JJ
cord-285262-690kpupt	94	24	immune	immune	JJ
cord-285262-690kpupt	94	25	response	response	NN
cord-285262-690kpupt	94	26	.	.	.
cord-285262-690kpupt	95	1	Hepatitis	Hepatitis	NNP
cord-285262-690kpupt	95	2	B	B	NNP
cord-285262-690kpupt	95	3	virus	virus	NN
cord-285262-690kpupt	96	1	x	x	LS
cord-285262-690kpupt	96	2	protein	protein	NNP
cord-285262-690kpupt	96	3	(	(	-LRB-
cord-285262-690kpupt	96	4	HBx	HBx	NNP
cord-285262-690kpupt	96	5	)	)	-RRB-
cord-285262-690kpupt	96	6	sensitizes	sensitize	VBZ
cord-285262-690kpupt	96	7	host	host	NN
cord-285262-690kpupt	96	8	cells	cell	NNS
cord-285262-690kpupt	96	9	to	to	IN
cord-285262-690kpupt	96	10	TNF	TNF	NNP
cord-285262-690kpupt	96	11	driven	drive	VBN
cord-285262-690kpupt	96	12	apoptosis	apoptosis	NN
cord-285262-690kpupt	96	13	by	by	IN
cord-285262-690kpupt	96	14	interfering	interfere	VBG
cord-285262-690kpupt	96	15	the	the	DT
cord-285262-690kpupt	96	16	anti	anti	JJ
cord-285262-690kpupt	96	17	-	-	JJ
cord-285262-690kpupt	96	18	apoptotic	apoptotic	JJ
cord-285262-690kpupt	96	19	function	function	NN
cord-285262-690kpupt	96	20	of	of	IN
cord-285262-690kpupt	96	21	cFLIP	cFLIP	NNP
cord-285262-690kpupt	96	22	,	,	,
cord-285262-690kpupt	96	23	thereby	thereby	RB
cord-285262-690kpupt	96	24	resulting	result	VBG
cord-285262-690kpupt	96	25	in	in	IN
cord-285262-690kpupt	96	26	caspase-8	caspase-8	NNP
cord-285262-690kpupt	96	27	over	over	IN
cord-285262-690kpupt	96	28	-	-	HYPH
cord-285262-690kpupt	96	29	activation	activation	NN
cord-285262-690kpupt	96	30	upon	upon	IN
cord-285262-690kpupt	96	31	stimuli	stimulus	NNS
cord-285262-690kpupt	96	32	(	(	-LRB-
cord-285262-690kpupt	96	33	Kim	Kim	NNP
cord-285262-690kpupt	96	34	and	and	CC
cord-285262-690kpupt	96	35	Seong	Seong	NNP
cord-285262-690kpupt	96	36	,	,	,
cord-285262-690kpupt	96	37	2003	2003	CD
cord-285262-690kpupt	96	38	)	)	-RRB-
cord-285262-690kpupt	96	39	.	.	.
cord-285262-690kpupt	97	1	In	in	IN
cord-285262-690kpupt	97	2	addition	addition	NN
cord-285262-690kpupt	97	3	,	,	,
cord-285262-690kpupt	97	4	CTLs	CTLs	NNP
cord-285262-690kpupt	97	5	and	and	CC
cord-285262-690kpupt	97	6	NK	NK	NNP
cord-285262-690kpupt	97	7	cells	cell	NNS
cord-285262-690kpupt	97	8	induce	induce	VBP
cord-285262-690kpupt	97	9	apoptosis	apoptosis	NN
cord-285262-690kpupt	97	10	in	in	IN
cord-285262-690kpupt	97	11	virus	virus	NN
cord-285262-690kpupt	97	12	infected	infect	VBN
cord-285262-690kpupt	97	13	target	target	NN
cord-285262-690kpupt	97	14	cells	cell	NNS
cord-285262-690kpupt	97	15	through	through	IN
cord-285262-690kpupt	97	16	the	the	DT
cord-285262-690kpupt	97	17	action	action	NN
cord-285262-690kpupt	97	18	of	of	IN
cord-285262-690kpupt	97	19	secreted	secrete	VBN
cord-285262-690kpupt	97	20	effector	effector	NN
cord-285262-690kpupt	97	21	molecules	molecule	NNS
cord-285262-690kpupt	97	22	.	.	.
cord-285262-690kpupt	98	1	Granzyme	Granzyme	NNP
cord-285262-690kpupt	98	2	-	-	HYPH
cord-285262-690kpupt	98	3	B	B	NNP
cord-285262-690kpupt	98	4	enters	enter	VBZ
cord-285262-690kpupt	98	5	the	the	DT
cord-285262-690kpupt	98	6	cells	cell	NNS
cord-285262-690kpupt	98	7	along	along	IN
cord-285262-690kpupt	98	8	with	with	IN
cord-285262-690kpupt	98	9	another	another	DT
cord-285262-690kpupt	98	10	secreted	secrete	VBN
cord-285262-690kpupt	98	11	protein	protein	NN
cord-285262-690kpupt	98	12	called	call	VBN
cord-285262-690kpupt	98	13	perforin	perforin	NNP
cord-285262-690kpupt	98	14	(	(	-LRB-
cord-285262-690kpupt	98	15	Fig	Fig	NNP
cord-285262-690kpupt	98	16	.	.	.
cord-285262-690kpupt	98	17	1	1	CD
cord-285262-690kpupt	98	18	)	)	-RRB-
cord-285262-690kpupt	99	1	(	(	-LRB-
cord-285262-690kpupt	99	2	Lowin	Lowin	NNP
cord-285262-690kpupt	99	3	et	et	NNP
cord-285262-690kpupt	99	4	al	al	NNP
cord-285262-690kpupt	99	5	.	.	NNP
cord-285262-690kpupt	99	6	,	,	,
cord-285262-690kpupt	99	7	1994	1994	CD
cord-285262-690kpupt	99	8	;	;	:
cord-285262-690kpupt	99	9	Shresta	Shresta	NNP
cord-285262-690kpupt	99	10	et	et	NNP
cord-285262-690kpupt	99	11	al	al	NNP
cord-285262-690kpupt	99	12	.	.	NNP
cord-285262-690kpupt	99	13	,	,	,
cord-285262-690kpupt	99	14	1995	1995	CD
cord-285262-690kpupt	99	15	)	)	-RRB-
cord-285262-690kpupt	99	16	.	.	.
cord-285262-690kpupt	100	1	Granzyme	Granzyme	NNP
cord-285262-690kpupt	100	2	-	-	HYPH
cord-285262-690kpupt	100	3	B	B	NNP
cord-285262-690kpupt	100	4	is	be	VBZ
cord-285262-690kpupt	100	5	a	a	DT
cord-285262-690kpupt	100	6	serine	serine	NN
cord-285262-690kpupt	100	7	protease	protease	NN
cord-285262-690kpupt	100	8	that	that	WDT
cord-285262-690kpupt	100	9	has	have	VBZ
cord-285262-690kpupt	100	10	been	be	VBN
cord-285262-690kpupt	100	11	shown	show	VBN
cord-285262-690kpupt	100	12	to	to	TO
cord-285262-690kpupt	100	13	induce	induce	VB
cord-285262-690kpupt	100	14	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	100	15	apoptosis	apoptosis	NN
cord-285262-690kpupt	100	16	by	by	IN
cord-285262-690kpupt	100	17	inducing	induce	VBG
cord-285262-690kpupt	100	18	Bid	Bid	NNP
cord-285262-690kpupt	100	19	cleavage	cleavage	NN
cord-285262-690kpupt	100	20	and	and	CC
cord-285262-690kpupt	100	21	subsequent	subsequent	JJ
cord-285262-690kpupt	100	22	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	100	23	cytochrome	cytochrome	NN
cord-285262-690kpupt	100	24	-	-	HYPH
cord-285262-690kpupt	100	25	C	c	NN
cord-285262-690kpupt	100	26	release	release	NN
cord-285262-690kpupt	100	27	,	,	,
cord-285262-690kpupt	100	28	leading	lead	VBG
cord-285262-690kpupt	100	29	to	to	IN
cord-285262-690kpupt	100	30	caspase-9	caspase-9	NNP
cord-285262-690kpupt	100	31	activation	activation	NN
cord-285262-690kpupt	100	32	(	(	-LRB-
cord-285262-690kpupt	100	33	Pinkoski	Pinkoski	NNP
cord-285262-690kpupt	100	34	et	et	NNP
cord-285262-690kpupt	100	35	al	al	NNP
cord-285262-690kpupt	100	36	.	.	NNP
cord-285262-690kpupt	100	37	,	,	,
cord-285262-690kpupt	100	38	2001	2001	CD
cord-285262-690kpupt	100	39	)	)	-RRB-
cord-285262-690kpupt	100	40	.	.	.
cord-285262-690kpupt	101	1	Apart	apart	RB
cord-285262-690kpupt	101	2	from	from	IN
cord-285262-690kpupt	101	3	the	the	DT
cord-285262-690kpupt	101	4	significant	significant	JJ
cord-285262-690kpupt	101	5	role	role	NN
cord-285262-690kpupt	101	6	of	of	IN
cord-285262-690kpupt	101	7	immune	immune	JJ
cord-285262-690kpupt	101	8	system	system	NN
cord-285262-690kpupt	101	9	driven	drive	VBD
cord-285262-690kpupt	101	10	apoptotic	apoptotic	JJ
cord-285262-690kpupt	101	11	responses	response	NNS
cord-285262-690kpupt	101	12	,	,	,
cord-285262-690kpupt	101	13	a	a	DT
cord-285262-690kpupt	101	14	plethora	plethora	NN
cord-285262-690kpupt	101	15	of	of	IN
cord-285262-690kpupt	101	16	evidence	evidence	NN
cord-285262-690kpupt	101	17	demonstrates	demonstrate	VBZ
cord-285262-690kpupt	101	18	the	the	DT
cord-285262-690kpupt	101	19	relevance	relevance	NN
cord-285262-690kpupt	101	20	of	of	IN
cord-285262-690kpupt	101	21	apoptosis	apoptosis	NN
cord-285262-690kpupt	101	22	,	,	,
cord-285262-690kpupt	101	23	Fig	Fig	NNP
cord-285262-690kpupt	101	24	.	.	NNP
cord-285262-690kpupt	101	25	1	1	CD
cord-285262-690kpupt	101	26	Apoptosis	apoptosis	NN
cord-285262-690kpupt	101	27	signaling	signal	VBG
cord-285262-690kpupt	101	28	in	in	IN
cord-285262-690kpupt	101	29	response	response	NN
cord-285262-690kpupt	101	30	to	to	IN
cord-285262-690kpupt	101	31	infection	infection	NN
cord-285262-690kpupt	101	32	.	.	.
cord-285262-690kpupt	102	1	Extracellular	Extracellular	NNP
cord-285262-690kpupt	102	2	and	and	CC
cord-285262-690kpupt	102	3	intracellular	intracellular	JJ
cord-285262-690kpupt	102	4	Viral	Viral	NNP
cord-285262-690kpupt	102	5	RNA	RNA	NNP
cord-285262-690kpupt	102	6	(	(	-LRB-
cord-285262-690kpupt	102	7	vRNA	vrna	JJ
cord-285262-690kpupt	102	8	)	)	-RRB-
cord-285262-690kpupt	102	9	fragments	fragment	NNS
cord-285262-690kpupt	102	10	(	(	-LRB-
cord-285262-690kpupt	102	11	left	left	NN
cord-285262-690kpupt	102	12	)	)	-RRB-
cord-285262-690kpupt	102	13	activate	activate	VB
cord-285262-690kpupt	102	14	TLR3	TLR3	NNP
cord-285262-690kpupt	102	15	and	and	CC
cord-285262-690kpupt	102	16	RIG	rig	NN
cord-285262-690kpupt	102	17	-	-	:
cord-285262-690kpupt	102	18	I	-PRON-	PRP
cord-285262-690kpupt	102	19	,	,	,
cord-285262-690kpupt	102	20	respectively	respectively	RB
cord-285262-690kpupt	102	21	,	,	,
cord-285262-690kpupt	102	22	resulting	result	VBG
cord-285262-690kpupt	102	23	in	in	IN
cord-285262-690kpupt	102	24	IRF-3	IRF-3	NNP
cord-285262-690kpupt	102	25	activation	activation	NN
cord-285262-690kpupt	102	26	.	.	.
cord-285262-690kpupt	103	1	Cytoplasmic	cytoplasmic	JJ
cord-285262-690kpupt	103	2	viral	viral	JJ
cord-285262-690kpupt	103	3	,	,	,
cord-285262-690kpupt	103	4	bacterial	bacterial	JJ
cord-285262-690kpupt	103	5	or	or	CC
cord-285262-690kpupt	103	6	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	103	7	DNA	dna	NN
cord-285262-690kpupt	103	8	(	(	-LRB-
cord-285262-690kpupt	103	9	mtDNA	mtDNA	NNP
cord-285262-690kpupt	103	10	)	)	-RRB-
cord-285262-690kpupt	103	11	is	be	VBZ
cord-285262-690kpupt	103	12	detected	detect	VBN
cord-285262-690kpupt	103	13	by	by	IN
cord-285262-690kpupt	103	14	cGAS	cgas	NN
cord-285262-690kpupt	103	15	,	,	,
cord-285262-690kpupt	103	16	which	which	WDT
cord-285262-690kpupt	103	17	in	in	IN
cord-285262-690kpupt	103	18	turn	turn	NN
cord-285262-690kpupt	103	19	activates	activate	VBZ
cord-285262-690kpupt	103	20	the	the	DT
cord-285262-690kpupt	103	21	STING	sting	NN
cord-285262-690kpupt	103	22	pathway	pathway	NN
cord-285262-690kpupt	103	23	,	,	,
cord-285262-690kpupt	103	24	leading	lead	VBG
cord-285262-690kpupt	103	25	to	to	IN
cord-285262-690kpupt	103	26	apoptotic	apoptotic	JJ
cord-285262-690kpupt	103	27	signaling	signaling	NN
cord-285262-690kpupt	103	28	via	via	IN
cord-285262-690kpupt	103	29	a	a	DT
cord-285262-690kpupt	103	30	putative	putative	JJ
cord-285262-690kpupt	103	31	IRF-3	IRF-3	NNP
cord-285262-690kpupt	103	32	driven	drive	VBN
cord-285262-690kpupt	103	33	mechanism	mechanism	NN
cord-285262-690kpupt	103	34	.	.	.
cord-285262-690kpupt	104	1	Apoptosis	apoptosis	NN
cord-285262-690kpupt	104	2	can	can	MD
cord-285262-690kpupt	104	3	be	be	VB
cord-285262-690kpupt	104	4	triggered	trigger	VBN
cord-285262-690kpupt	104	5	by	by	IN
cord-285262-690kpupt	104	6	effector	effector	NN
cord-285262-690kpupt	104	7	cells	cell	NNS
cord-285262-690kpupt	104	8	of	of	IN
cord-285262-690kpupt	104	9	the	the	DT
cord-285262-690kpupt	104	10	immune	immune	JJ
cord-285262-690kpupt	104	11	system	system	NN
cord-285262-690kpupt	104	12	.	.	.
cord-285262-690kpupt	105	1	Ligation	ligation	NN
cord-285262-690kpupt	105	2	of	of	IN
cord-285262-690kpupt	105	3	the	the	DT
cord-285262-690kpupt	105	4	FASR	FASR	NNP
cord-285262-690kpupt	105	5	(	(	-LRB-
cord-285262-690kpupt	105	6	right	right	RB
cord-285262-690kpupt	105	7	)	)	-RRB-
cord-285262-690kpupt	105	8	leads	lead	VBZ
cord-285262-690kpupt	105	9	to	to	IN
cord-285262-690kpupt	105	10	the	the	DT
cord-285262-690kpupt	105	11	assembly	assembly	NN
cord-285262-690kpupt	105	12	of	of	IN
cord-285262-690kpupt	105	13	the	the	DT
cord-285262-690kpupt	105	14	adaptor	adaptor	NN
cord-285262-690kpupt	105	15	FADD	FADD	NNP
cord-285262-690kpupt	105	16	and	and	CC
cord-285262-690kpupt	105	17	caspase-8	caspase-8	NNP
cord-285262-690kpupt	105	18	containing	contain	VBG
cord-285262-690kpupt	105	19	DISC	DISC	NNP
cord-285262-690kpupt	105	20	,	,	,
cord-285262-690kpupt	105	21	resulting	result	VBG
cord-285262-690kpupt	105	22	in	in	IN
cord-285262-690kpupt	105	23	the	the	DT
cord-285262-690kpupt	105	24	activation	activation	NN
cord-285262-690kpupt	105	25	of	of	IN
cord-285262-690kpupt	105	26	caspase-8	caspase-8	NNP
cord-285262-690kpupt	105	27	.	.	.
cord-285262-690kpupt	106	1	Activation	activation	NN
cord-285262-690kpupt	106	2	of	of	IN
cord-285262-690kpupt	106	3	caspase-8	caspase-8	NNP
cord-285262-690kpupt	106	4	either	either	CC
cord-285262-690kpupt	106	5	results	result	VBZ
cord-285262-690kpupt	106	6	in	in	IN
cord-285262-690kpupt	106	7	the	the	DT
cord-285262-690kpupt	106	8	direct	direct	JJ
cord-285262-690kpupt	106	9	cleavage	cleavage	NN
cord-285262-690kpupt	106	10	of	of	IN
cord-285262-690kpupt	106	11	caspase-3/7	caspase-3/7	NN
cord-285262-690kpupt	106	12	or	or	CC
cord-285262-690kpupt	106	13	leads	lead	VBZ
cord-285262-690kpupt	106	14	to	to	IN
cord-285262-690kpupt	106	15	the	the	DT
cord-285262-690kpupt	106	16	BID	BID	NNP
cord-285262-690kpupt	106	17	cleavage	cleavage	NN
cord-285262-690kpupt	106	18	(	(	-LRB-
cord-285262-690kpupt	106	19	tBID	tBID	NNS
cord-285262-690kpupt	106	20	)	)	-RRB-
cord-285262-690kpupt	106	21	driven	drive	VBN
cord-285262-690kpupt	106	22	amplification	amplification	NN
cord-285262-690kpupt	106	23	loop	loop	NN
cord-285262-690kpupt	106	24	of	of	IN
cord-285262-690kpupt	106	25	the	the	DT
cord-285262-690kpupt	106	26	intrinsic	intrinsic	JJ
cord-285262-690kpupt	106	27	pathway	pathway	NN
cord-285262-690kpupt	106	28	.	.	.
cord-285262-690kpupt	107	1	The	the	DT
cord-285262-690kpupt	107	2	secretion	secretion	NN
cord-285262-690kpupt	107	3	of	of	IN
cord-285262-690kpupt	107	4	the	the	DT
cord-285262-690kpupt	107	5	pro	pro	JJ
cord-285262-690kpupt	107	6	-	-	JJ
cord-285262-690kpupt	107	7	apoptotic	apoptotic	JJ
cord-285262-690kpupt	107	8	perforin	perforin	NN
cord-285262-690kpupt	107	9	and	and	CC
cord-285262-690kpupt	107	10	granzyme	granzyme	NNS
cord-285262-690kpupt	107	11	-	-	HYPH
cord-285262-690kpupt	107	12	B	b	NN
cord-285262-690kpupt	107	13	(	(	-LRB-
cord-285262-690kpupt	107	14	middle	middle	NN
cord-285262-690kpupt	107	15	)	)	-RRB-
cord-285262-690kpupt	107	16	triggers	trigger	VBZ
cord-285262-690kpupt	107	17	the	the	DT
cord-285262-690kpupt	107	18	activation	activation	NN
cord-285262-690kpupt	107	19	of	of	IN
cord-285262-690kpupt	107	20	the	the	DT
cord-285262-690kpupt	107	21	intrinsic	intrinsic	JJ
cord-285262-690kpupt	107	22	apoptotic	apoptotic	JJ
cord-285262-690kpupt	107	23	pathway	pathway	NN
cord-285262-690kpupt	107	24	.	.	.
cord-285262-690kpupt	108	1	unleashed	unleash	VBN
cord-285262-690kpupt	108	2	directly	directly	RB
cord-285262-690kpupt	108	3	by	by	IN
cord-285262-690kpupt	108	4	the	the	DT
cord-285262-690kpupt	108	5	viral	viral	JJ
cord-285262-690kpupt	108	6	pathogens	pathogen	NNS
cord-285262-690kpupt	108	7	intracellularly	intracellularly	RB
cord-285262-690kpupt	108	8	.	.	.
cord-285262-690kpupt	109	1	Enterovirus	enterovirus	NN
cord-285262-690kpupt	109	2	71	71	CD
cord-285262-690kpupt	109	3	(	(	-LRB-
cord-285262-690kpupt	109	4	EV71	EV71	NNP
cord-285262-690kpupt	109	5	)	)	-RRB-
cord-285262-690kpupt	109	6	,	,	,
cord-285262-690kpupt	109	7	a	a	DT
cord-285262-690kpupt	109	8	virus	virus	NN
cord-285262-690kpupt	109	9	in	in	IN
cord-285262-690kpupt	109	10	the	the	DT
cord-285262-690kpupt	109	11	family	family	NN
cord-285262-690kpupt	109	12	of	of	IN
cord-285262-690kpupt	109	13	Picornaviridae	Picornaviridae	NNP
cord-285262-690kpupt	109	14	,	,	,
cord-285262-690kpupt	109	15	is	be	VBZ
cord-285262-690kpupt	109	16	one	one	CD
cord-285262-690kpupt	109	17	of	of	IN
cord-285262-690kpupt	109	18	the	the	DT
cord-285262-690kpupt	109	19	main	main	JJ
cord-285262-690kpupt	109	20	causative	causative	JJ
cord-285262-690kpupt	109	21	agents	agent	NNS
cord-285262-690kpupt	109	22	of	of	IN
cord-285262-690kpupt	109	23	hand	hand	NN
cord-285262-690kpupt	109	24	,	,	,
cord-285262-690kpupt	109	25	foot	foot	NN
cord-285262-690kpupt	109	26	and	and	CC
cord-285262-690kpupt	109	27	mouth	mouth	NN
cord-285262-690kpupt	109	28	disease	disease	NN
cord-285262-690kpupt	109	29	in	in	IN
cord-285262-690kpupt	109	30	infected	infected	JJ
cord-285262-690kpupt	109	31	infants	infant	NNS
cord-285262-690kpupt	109	32	and	and	CC
cord-285262-690kpupt	109	33	young	young	JJ
cord-285262-690kpupt	109	34	children	child	NNS
cord-285262-690kpupt	109	35	.	.	.
cord-285262-690kpupt	110	1	EV71	EV71	NNP
cord-285262-690kpupt	110	2	can	can	MD
cord-285262-690kpupt	110	3	directly	directly	RB
cord-285262-690kpupt	110	4	induce	induce	VB
cord-285262-690kpupt	110	5	the	the	DT
cord-285262-690kpupt	110	6	intrinsic	intrinsic	JJ
cord-285262-690kpupt	110	7	apoptotic	apoptotic	JJ
cord-285262-690kpupt	110	8	pathway	pathway	NN
cord-285262-690kpupt	110	9	by	by	IN
cord-285262-690kpupt	110	10	activating	activate	VBG
cord-285262-690kpupt	110	11	BAX	BAX	NNP
cord-285262-690kpupt	110	12	and	and	CC
cord-285262-690kpupt	110	13	the	the	DT
cord-285262-690kpupt	110	14	subsequent	subsequent	JJ
cord-285262-690kpupt	110	15	MOMP	MOMP	NNS
cord-285262-690kpupt	110	16	,	,	,
cord-285262-690kpupt	110	17	leading	lead	VBG
cord-285262-690kpupt	110	18	to	to	IN
cord-285262-690kpupt	110	19	the	the	DT
cord-285262-690kpupt	110	20	caspase-9	caspase-9	NNP
cord-285262-690kpupt	110	21	driven	drive	VBN
cord-285262-690kpupt	110	22	apoptotic	apoptotic	JJ
cord-285262-690kpupt	110	23	signal	signal	NN
cord-285262-690kpupt	110	24	.	.	.
cord-285262-690kpupt	111	1	Importantly	importantly	RB
cord-285262-690kpupt	111	2	,	,	,
cord-285262-690kpupt	111	3	depletion	depletion	NN
cord-285262-690kpupt	111	4	of	of	IN
cord-285262-690kpupt	111	5	caspase-8	caspase-8	NNP
cord-285262-690kpupt	111	6	has	have	VBZ
cord-285262-690kpupt	111	7	no	no	DT
cord-285262-690kpupt	111	8	influence	influence	NN
cord-285262-690kpupt	111	9	on	on	IN
cord-285262-690kpupt	111	10	the	the	DT
cord-285262-690kpupt	111	11	cell	cell	NN
cord-285262-690kpupt	111	12	death	death	NN
cord-285262-690kpupt	111	13	initiated	initiate	VBN
cord-285262-690kpupt	111	14	by	by	IN
cord-285262-690kpupt	111	15	the	the	DT
cord-285262-690kpupt	111	16	virus	virus	NN
cord-285262-690kpupt	111	17	,	,	,
cord-285262-690kpupt	111	18	excluding	exclude	VBG
cord-285262-690kpupt	111	19	the	the	DT
cord-285262-690kpupt	111	20	role	role	NN
cord-285262-690kpupt	111	21	of	of	IN
cord-285262-690kpupt	111	22	a	a	DT
cord-285262-690kpupt	111	23	DR	DR	NNP
cord-285262-690kpupt	111	24	driven	drive	VBN
cord-285262-690kpupt	111	25	external	external	JJ
cord-285262-690kpupt	111	26	stimulation	stimulation	NN
cord-285262-690kpupt	111	27	(	(	-LRB-
cord-285262-690kpupt	111	28	Han	Han	NNP
cord-285262-690kpupt	111	29	and	and	CC
cord-285262-690kpupt	111	30	Cong	Cong	NNP
cord-285262-690kpupt	111	31	,	,	,
cord-285262-690kpupt	111	32	2017	2017	CD
cord-285262-690kpupt	111	33	)	)	-RRB-
cord-285262-690kpupt	111	34	.	.	.
cord-285262-690kpupt	112	1	Analogously	analogously	RB
cord-285262-690kpupt	112	2	,	,	,
cord-285262-690kpupt	112	3	Coxsackievirus	Coxsackievirus	NNP
cord-285262-690kpupt	112	4	A16	A16	NNP
cord-285262-690kpupt	112	5	(	(	-LRB-
cord-285262-690kpupt	112	6	CA16	CA16	NNP
cord-285262-690kpupt	112	7	)	)	-RRB-
cord-285262-690kpupt	112	8	can	can	MD
cord-285262-690kpupt	112	9	trigger	trigger	VB
cord-285262-690kpupt	112	10	both	both	CC
cord-285262-690kpupt	112	11	the	the	DT
cord-285262-690kpupt	112	12	extrinsic	extrinsic	NN
cord-285262-690kpupt	112	13	and	and	CC
cord-285262-690kpupt	112	14	the	the	DT
cord-285262-690kpupt	112	15	intrinsic	intrinsic	JJ
cord-285262-690kpupt	112	16	way	way	NN
cord-285262-690kpupt	112	17	of	of	IN
cord-285262-690kpupt	112	18	apoptosis	apoptosis	NN
cord-285262-690kpupt	112	19	in	in	IN
cord-285262-690kpupt	112	20	human	human	JJ
cord-285262-690kpupt	112	21	neuronal	neuronal	JJ
cord-285262-690kpupt	112	22	and	and	CC
cord-285262-690kpupt	112	23	muscle	muscle	NN
cord-285262-690kpupt	112	24	cell	cell	NN
cord-285262-690kpupt	112	25	lines	line	NNS
cord-285262-690kpupt	112	26	accompanied	accompany	VBN
cord-285262-690kpupt	112	27	by	by	IN
cord-285262-690kpupt	112	28	the	the	DT
cord-285262-690kpupt	112	29	typical	typical	JJ
cord-285262-690kpupt	112	30	apoptotic	apoptotic	JJ
cord-285262-690kpupt	112	31	features	feature	NNS
cord-285262-690kpupt	112	32	:	:	:
cord-285262-690kpupt	112	33	caspase	caspase	NN
cord-285262-690kpupt	112	34	cleavage	cleavage	NN
cord-285262-690kpupt	112	35	,	,	,
cord-285262-690kpupt	112	36	DNA	dna	NN
cord-285262-690kpupt	112	37	fragmentation	fragmentation	NN
cord-285262-690kpupt	112	38	,	,	,
cord-285262-690kpupt	112	39	and	and	CC
cord-285262-690kpupt	112	40	PS	PS	NNP
cord-285262-690kpupt	112	41	translocation	translocation	NN
cord-285262-690kpupt	112	42	(	(	-LRB-
cord-285262-690kpupt	113	1	Li	Li	NNP
cord-285262-690kpupt	113	2	et	et	NNP
cord-285262-690kpupt	113	3	al	al	NNP
cord-285262-690kpupt	113	4	.	.	.
cord-285262-690kpupt	114	1	,	,	,
cord-285262-690kpupt	114	2	2014	2014	CD
cord-285262-690kpupt	114	3	)	)	-RRB-
cord-285262-690kpupt	114	4	.	.	.
cord-285262-690kpupt	115	1	The	the	DT
cord-285262-690kpupt	115	2	West	West	NNP
cord-285262-690kpupt	115	3	Nile	Nile	NNP
cord-285262-690kpupt	115	4	virus	virus	NN
cord-285262-690kpupt	115	5	(	(	-LRB-
cord-285262-690kpupt	115	6	WNV	WNV	NNP
cord-285262-690kpupt	115	7	)	)	-RRB-
cord-285262-690kpupt	115	8	is	be	VBZ
cord-285262-690kpupt	115	9	a	a	DT
cord-285262-690kpupt	115	10	mosquito	mosquito	NN
cord-285262-690kpupt	115	11	born	bear	VBN
cord-285262-690kpupt	115	12	singlestranded	singlestranded	NNP
cord-285262-690kpupt	115	13	RNA	RNA	NNP
cord-285262-690kpupt	115	14	virus	virus	NN
cord-285262-690kpupt	115	15	,	,	,
cord-285262-690kpupt	115	16	causing	cause	VBG
cord-285262-690kpupt	115	17	West	West	NNP
cord-285262-690kpupt	115	18	Nile	Nile	NNP
cord-285262-690kpupt	115	19	encephalitis	encephalitis	RB
cord-285262-690kpupt	115	20	in	in	IN
cord-285262-690kpupt	115	21	humans	human	NNS
cord-285262-690kpupt	115	22	.	.	.
cord-285262-690kpupt	116	1	The	the	DT
cord-285262-690kpupt	116	2	non	non	JJ
cord-285262-690kpupt	116	3	-	-	JJ
cord-285262-690kpupt	116	4	structural	structural	JJ
cord-285262-690kpupt	116	5	proteins	protein	NNS
cord-285262-690kpupt	116	6	2B	2b	CD
cord-285262-690kpupt	116	7	and	and	CC
cord-285262-690kpupt	116	8	3	3	CD
cord-285262-690kpupt	117	1	(	(	-LRB-
cord-285262-690kpupt	117	2	NS2B	NS2B	NNP
cord-285262-690kpupt	117	3	and	and	CC
cord-285262-690kpupt	117	4	NS3	ns3	RB
cord-285262-690kpupt	117	5	)	)	-RRB-
cord-285262-690kpupt	117	6	conduct	conduct	VB
cord-285262-690kpupt	117	7	the	the	DT
cord-285262-690kpupt	117	8	proteolytic	proteolytic	JJ
cord-285262-690kpupt	117	9	cleavage	cleavage	NN
cord-285262-690kpupt	117	10	and	and	CC
cord-285262-690kpupt	117	11	the	the	DT
cord-285262-690kpupt	117	12	processing	processing	NN
cord-285262-690kpupt	117	13	of	of	IN
cord-285262-690kpupt	117	14	the	the	DT
cord-285262-690kpupt	117	15	large	large	JJ
cord-285262-690kpupt	117	16	viral	viral	JJ
cord-285262-690kpupt	117	17	polyprotein	polyprotein	NN
cord-285262-690kpupt	117	18	,	,	,
cord-285262-690kpupt	117	19	that	that	WDT
cord-285262-690kpupt	117	20	is	be	VBZ
cord-285262-690kpupt	117	21	formed	form	VBN
cord-285262-690kpupt	117	22	directly	directly	RB
cord-285262-690kpupt	117	23	from	from	IN
cord-285262-690kpupt	117	24	the	the	DT
cord-285262-690kpupt	117	25	RNA	RNA	NNP
cord-285262-690kpupt	117	26	of	of	IN
cord-285262-690kpupt	117	27	the	the	DT
cord-285262-690kpupt	117	28	virus	virus	NN
cord-285262-690kpupt	117	29	.	.	.
cord-285262-690kpupt	118	1	Besides	besides	RB
cord-285262-690kpupt	118	2	,	,	,
cord-285262-690kpupt	118	3	NS3	ns3	RB
cord-285262-690kpupt	118	4	initiates	initiate	VBZ
cord-285262-690kpupt	118	5	apoptosis	apoptosis	NN
cord-285262-690kpupt	118	6	in	in	IN
cord-285262-690kpupt	118	7	a	a	DT
cord-285262-690kpupt	118	8	caspase-8	caspase-8	NNP
cord-285262-690kpupt	118	9	dependent	dependent	JJ
cord-285262-690kpupt	118	10	way	way	NN
cord-285262-690kpupt	118	11	,	,	,
cord-285262-690kpupt	118	12	which	which	WDT
cord-285262-690kpupt	118	13	then	then	RB
cord-285262-690kpupt	118	14	results	result	VBZ
cord-285262-690kpupt	118	15	in	in	IN
cord-285262-690kpupt	118	16	typical	typical	JJ
cord-285262-690kpupt	118	17	apoptotic	apoptotic	JJ
cord-285262-690kpupt	118	18	features	feature	NNS
cord-285262-690kpupt	118	19	in	in	IN
cord-285262-690kpupt	118	20	multiple	multiple	JJ
cord-285262-690kpupt	118	21	human	human	JJ
cord-285262-690kpupt	118	22	cell	cell	NN
cord-285262-690kpupt	118	23	lines	line	NNS
cord-285262-690kpupt	118	24	(	(	-LRB-
cord-285262-690kpupt	118	25	Ramanathan	Ramanathan	NNP
cord-285262-690kpupt	118	26	et	et	NNP
cord-285262-690kpupt	118	27	al	al	NNP
cord-285262-690kpupt	118	28	.	.	NNP
cord-285262-690kpupt	118	29	,	,	,
cord-285262-690kpupt	118	30	2006	2006	CD
cord-285262-690kpupt	118	31	)	)	-RRB-
cord-285262-690kpupt	118	32	.	.	.
cord-285262-690kpupt	119	1	The	the	DT
cord-285262-690kpupt	119	2	virus	virus	NN
cord-285262-690kpupt	119	3	-	-	HYPH
cord-285262-690kpupt	119	4	host	host	NN
cord-285262-690kpupt	119	5	co	co	NN
cord-285262-690kpupt	119	6	-	-	NN
cord-285262-690kpupt	119	7	evolution	evolution	NN
cord-285262-690kpupt	119	8	is	be	VBZ
cord-285262-690kpupt	119	9	well	well	RB
cord-285262-690kpupt	119	10	demonstrated	demonstrate	VBN
cord-285262-690kpupt	119	11	by	by	IN
cord-285262-690kpupt	119	12	the	the	DT
cord-285262-690kpupt	119	13	examples	example	NNS
cord-285262-690kpupt	119	14	,	,	,
cord-285262-690kpupt	119	15	where	where	WRB
cord-285262-690kpupt	119	16	the	the	DT
cord-285262-690kpupt	119	17	pathogen	pathogen	NN
cord-285262-690kpupt	119	18	has	have	VBZ
cord-285262-690kpupt	119	19	developed	develop	VBN
cord-285262-690kpupt	119	20	strategies	strategy	NNS
cord-285262-690kpupt	119	21	to	to	TO
cord-285262-690kpupt	119	22	hijack	hijack	VB
cord-285262-690kpupt	119	23	the	the	DT
cord-285262-690kpupt	119	24	originally	originally	RB
cord-285262-690kpupt	119	25	protective	protective	JJ
cord-285262-690kpupt	119	26	apoptotic	apoptotic	JJ
cord-285262-690kpupt	119	27	signaling	signaling	NN
cord-285262-690kpupt	119	28	of	of	IN
cord-285262-690kpupt	119	29	the	the	DT
cord-285262-690kpupt	119	30	host	host	NN
cord-285262-690kpupt	119	31	.	.	.
cord-285262-690kpupt	120	1	Chikungunya	chikungunya	NN
cord-285262-690kpupt	120	2	virus	virus	NN
cord-285262-690kpupt	120	3	(	(	-LRB-
cord-285262-690kpupt	120	4	CHIKV	CHIKV	NNP
cord-285262-690kpupt	120	5	)	)	-RRB-
cord-285262-690kpupt	120	6	was	be	VBD
cord-285262-690kpupt	120	7	reported	report	VBN
cord-285262-690kpupt	120	8	to	to	TO
cord-285262-690kpupt	120	9	infect	infect	VB
cord-285262-690kpupt	120	10	macrophages	macrophage	NNS
cord-285262-690kpupt	120	11	and	and	CC
cord-285262-690kpupt	120	12	induce	induce	VB
cord-285262-690kpupt	120	13	apoptosis	apoptosis	NN
cord-285262-690kpupt	120	14	by	by	IN
cord-285262-690kpupt	120	15	triggering	trigger	VBG
cord-285262-690kpupt	120	16	the	the	DT
cord-285262-690kpupt	120	17	intrinsic	intrinsic	JJ
cord-285262-690kpupt	120	18	apoptotic	apoptotic	JJ
cord-285262-690kpupt	120	19	pathway	pathway	NN
cord-285262-690kpupt	120	20	via	via	IN
cord-285262-690kpupt	120	21	the	the	DT
cord-285262-690kpupt	120	22	caspase-9/-3	caspase-9/-3	NNP
cord-285262-690kpupt	120	23	axis	axis	NN
cord-285262-690kpupt	121	1	(	(	-LRB-
cord-285262-690kpupt	121	2	Nayak	Nayak	NNP
cord-285262-690kpupt	121	3	et	et	NNP
cord-285262-690kpupt	121	4	al	al	NNP
cord-285262-690kpupt	121	5	.	.	NNP
cord-285262-690kpupt	121	6	,	,	,
cord-285262-690kpupt	121	7	2017	2017	CD
cord-285262-690kpupt	121	8	)	)	-RRB-
cord-285262-690kpupt	121	9	.	.	.
cord-285262-690kpupt	122	1	Intriguingly	intriguingly	RB
cord-285262-690kpupt	122	2	,	,	,
cord-285262-690kpupt	122	3	CHIKV	CHIKV	NNP
cord-285262-690kpupt	122	4	virus	virus	NN
cord-285262-690kpupt	122	5	exploits	exploit	VBZ
cord-285262-690kpupt	122	6	the	the	DT
cord-285262-690kpupt	122	7	formation	formation	NN
cord-285262-690kpupt	122	8	of	of	IN
cord-285262-690kpupt	122	9	the	the	DT
cord-285262-690kpupt	122	10	apoptotic	apoptotic	JJ
cord-285262-690kpupt	122	11	blebs	blebs	NN
cord-285262-690kpupt	122	12	to	to	TO
cord-285262-690kpupt	122	13	transport	transport	VB
cord-285262-690kpupt	122	14	the	the	DT
cord-285262-690kpupt	122	15	virus	virus	NN
cord-285262-690kpupt	122	16	particles	particle	NNS
cord-285262-690kpupt	122	17	into	into	IN
cord-285262-690kpupt	122	18	neighboring	neighboring	NN
cord-285262-690kpupt	122	19	macrophages	macrophage	NNS
cord-285262-690kpupt	122	20	(	(	-LRB-
cord-285262-690kpupt	122	21	Krejbich	Krejbich	NNP
cord-285262-690kpupt	122	22	-	-	HYPH
cord-285262-690kpupt	122	23	Trotot	Trotot	NNP
cord-285262-690kpupt	122	24	et	et	NNP
cord-285262-690kpupt	122	25	al	al	NNP
cord-285262-690kpupt	122	26	.	.	NNP
cord-285262-690kpupt	122	27	,	,	,
cord-285262-690kpupt	122	28	2011	2011	CD
cord-285262-690kpupt	122	29	)	)	-RRB-
cord-285262-690kpupt	122	30	.	.	.
cord-285262-690kpupt	123	1	The	the	DT
cord-285262-690kpupt	123	2	apoptosis	apoptosis	NN
cord-285262-690kpupt	123	3	can	can	MD
cord-285262-690kpupt	123	4	be	be	VB
cord-285262-690kpupt	123	5	beneficial	beneficial	JJ
cord-285262-690kpupt	123	6	for	for	IN
cord-285262-690kpupt	123	7	the	the	DT
cord-285262-690kpupt	123	8	pathogen	pathogen	NN
cord-285262-690kpupt	123	9	,	,	,
cord-285262-690kpupt	123	10	if	if	IN
cord-285262-690kpupt	123	11	the	the	DT
cord-285262-690kpupt	123	12	defensive	defensive	JJ
cord-285262-690kpupt	123	13	immune	immune	JJ
cord-285262-690kpupt	123	14	cells	cell	NNS
cord-285262-690kpupt	123	15	are	be	VBP
cord-285262-690kpupt	123	16	selectively	selectively	RB
cord-285262-690kpupt	123	17	deleted	delete	VBN
cord-285262-690kpupt	123	18	by	by	IN
cord-285262-690kpupt	123	19	the	the	DT
cord-285262-690kpupt	123	20	virus	virus	NN
cord-285262-690kpupt	123	21	-	-	HYPH
cord-285262-690kpupt	123	22	driven	drive	VBN
cord-285262-690kpupt	123	23	cell	cell	NN
cord-285262-690kpupt	123	24	death	death	NN
cord-285262-690kpupt	123	25	signals	signal	NNS
cord-285262-690kpupt	123	26	.	.	.
cord-285262-690kpupt	124	1	The	the	DT
cord-285262-690kpupt	124	2	human	human	JJ
cord-285262-690kpupt	124	3	immunodeficiency	immunodeficiency	NN
cord-285262-690kpupt	124	4	virus	virus	NN
cord-285262-690kpupt	124	5	(	(	-LRB-
cord-285262-690kpupt	124	6	HIV	HIV	NNP
cord-285262-690kpupt	124	7	)	)	-RRB-
cord-285262-690kpupt	124	8	protease	protease	NN
cord-285262-690kpupt	124	9	cleaves	cleave	VBZ
cord-285262-690kpupt	124	10	procaspase-8	procaspase-8	NNP
cord-285262-690kpupt	124	11	to	to	IN
cord-285262-690kpupt	124	12	a	a	DT
cord-285262-690kpupt	124	13	41	41	CD
cord-285262-690kpupt	124	14	kDa	kDa	NNP
cord-285262-690kpupt	124	15	fragment	fragment	NN
cord-285262-690kpupt	124	16	,	,	,
cord-285262-690kpupt	124	17	called	call	VBN
cord-285262-690kpupt	124	18	casp8p41	casp8p41	NNP
cord-285262-690kpupt	124	19	,	,	,
cord-285262-690kpupt	124	20	which	which	WDT
cord-285262-690kpupt	124	21	lacks	lack	VBZ
cord-285262-690kpupt	124	22	the	the	DT
cord-285262-690kpupt	124	23	catalytic	catalytic	JJ
cord-285262-690kpupt	124	24	site	site	NN
cord-285262-690kpupt	124	25	of	of	IN
cord-285262-690kpupt	124	26	the	the	DT
cord-285262-690kpupt	124	27	caspase	caspase	NN
cord-285262-690kpupt	124	28	.	.	.
cord-285262-690kpupt	125	1	Interestingly	interestingly	RB
cord-285262-690kpupt	125	2	,	,	,
cord-285262-690kpupt	125	3	the	the	DT
cord-285262-690kpupt	125	4	catalytically	catalytically	RB
cord-285262-690kpupt	125	5	inactive	inactive	JJ
cord-285262-690kpupt	125	6	fragment	fragment	NN
cord-285262-690kpupt	125	7	can	can	MD
cord-285262-690kpupt	125	8	facilitate	facilitate	VB
cord-285262-690kpupt	125	9	BAX	BAX	NNP
cord-285262-690kpupt	125	10	oligomerization	oligomerization	NN
cord-285262-690kpupt	125	11	and	and	CC
cord-285262-690kpupt	125	12	apoptosis	apoptosis	NN
cord-285262-690kpupt	125	13	in	in	IN
cord-285262-690kpupt	125	14	the	the	DT
cord-285262-690kpupt	125	15	host	host	NN
cord-285262-690kpupt	125	16	CD4	CD4	NNP
cord-285262-690kpupt	125	17	cells	cell	NNS
cord-285262-690kpupt	125	18	(	(	-LRB-
cord-285262-690kpupt	125	19	Sainski	Sainski	NNP
cord-285262-690kpupt	125	20	et	et	NNP
cord-285262-690kpupt	125	21	al	al	NNP
cord-285262-690kpupt	125	22	.	.	NNP
cord-285262-690kpupt	125	23	,	,	,
cord-285262-690kpupt	125	24	2014	2014	CD
cord-285262-690kpupt	125	25	)	)	-RRB-
cord-285262-690kpupt	125	26	.	.	.
cord-285262-690kpupt	126	1	Probably	probably	RB
cord-285262-690kpupt	126	2	one	one	CD
cord-285262-690kpupt	126	3	of	of	IN
cord-285262-690kpupt	126	4	the	the	DT
cord-285262-690kpupt	126	5	most	most	RBS
cord-285262-690kpupt	126	6	thrilling	thrilling	JJ
cord-285262-690kpupt	126	7	question	question	NN
cord-285262-690kpupt	126	8	,	,	,
cord-285262-690kpupt	126	9	emerging	emerge	VBG
cord-285262-690kpupt	126	10	from	from	IN
cord-285262-690kpupt	126	11	the	the	DT
cord-285262-690kpupt	126	12	studies	study	NNS
cord-285262-690kpupt	126	13	on	on	IN
cord-285262-690kpupt	126	14	the	the	DT
cord-285262-690kpupt	126	15	host	host	NN
cord-285262-690kpupt	126	16	-	-	HYPH
cord-285262-690kpupt	126	17	pathogen	pathogen	NN
cord-285262-690kpupt	126	18	interactions	interaction	NNS
cord-285262-690kpupt	126	19	,	,	,
cord-285262-690kpupt	126	20	is	be	VBZ
cord-285262-690kpupt	126	21	how	how	WRB
cord-285262-690kpupt	126	22	the	the	DT
cord-285262-690kpupt	126	23	host	host	NN
cord-285262-690kpupt	126	24	organisms	organism	NNS
cord-285262-690kpupt	126	25	differentiate	differentiate	VBP
cord-285262-690kpupt	126	26	between	between	IN
cord-285262-690kpupt	126	27	friend	friend	NN
cord-285262-690kpupt	126	28	and	and	CC
cord-285262-690kpupt	126	29	foe	foe	NN
cord-285262-690kpupt	126	30	.	.	.
cord-285262-690kpupt	127	1	Detection	detection	NN
cord-285262-690kpupt	127	2	of	of	IN
cord-285262-690kpupt	127	3	intracellular	intracellular	JJ
cord-285262-690kpupt	127	4	pathogens	pathogen	NNS
cord-285262-690kpupt	127	5	in	in	IN
cord-285262-690kpupt	127	6	mammalian	mammalian	JJ
cord-285262-690kpupt	127	7	cells	cell	NNS
cord-285262-690kpupt	127	8	is	be	VBZ
cord-285262-690kpupt	127	9	a	a	DT
cord-285262-690kpupt	127	10	multifaceted	multifaceted	JJ
cord-285262-690kpupt	127	11	mechanism	mechanism	NN
cord-285262-690kpupt	127	12	,	,	,
cord-285262-690kpupt	127	13	which	which	WDT
cord-285262-690kpupt	127	14	involves	involve	VBZ
cord-285262-690kpupt	127	15	the	the	DT
cord-285262-690kpupt	127	16	recognition	recognition	NN
cord-285262-690kpupt	127	17	of	of	IN
cord-285262-690kpupt	127	18	various	various	JJ
cord-285262-690kpupt	127	19	signals	signal	NNS
cord-285262-690kpupt	127	20	deriving	derive	VBG
cord-285262-690kpupt	127	21	from	from	IN
cord-285262-690kpupt	127	22	the	the	DT
cord-285262-690kpupt	127	23	pathogens	pathogen	NNS
cord-285262-690kpupt	127	24	,	,	,
cord-285262-690kpupt	127	25	collectively	collectively	RB
cord-285262-690kpupt	127	26	termed	term	VBN
cord-285262-690kpupt	127	27	pathogen	pathogen	NN
cord-285262-690kpupt	127	28	associated	associate	VBD
cord-285262-690kpupt	127	29	molecular	molecular	JJ
cord-285262-690kpupt	127	30	patterns	pattern	NNS
cord-285262-690kpupt	127	31	(	(	-LRB-
cord-285262-690kpupt	127	32	PAMPs	pamp	NNS
cord-285262-690kpupt	127	33	)	)	-RRB-
cord-285262-690kpupt	127	34	.	.	.
cord-285262-690kpupt	128	1	For	for	IN
cord-285262-690kpupt	128	2	instance	instance	NN
cord-285262-690kpupt	128	3	,	,	,
cord-285262-690kpupt	128	4	the	the	DT
cord-285262-690kpupt	128	5	viral	viral	JJ
cord-285262-690kpupt	128	6	RNA	RNA	NNP
cord-285262-690kpupt	128	7	and	and	CC
cord-285262-690kpupt	128	8	DNA	dna	NN
cord-285262-690kpupt	128	9	fragments	fragment	NNS
cord-285262-690kpupt	128	10	represent	represent	VBP
cord-285262-690kpupt	128	11	a	a	DT
cord-285262-690kpupt	128	12	prominent	prominent	JJ
cord-285262-690kpupt	128	13	group	group	NN
cord-285262-690kpupt	128	14	of	of	IN
cord-285262-690kpupt	128	15	PAMPs	pamp	NNS
cord-285262-690kpupt	128	16	.	.	.
cord-285262-690kpupt	129	1	PAMPs	pamp	NNS
cord-285262-690kpupt	129	2	are	be	VBP
cord-285262-690kpupt	129	3	detected	detect	VBN
cord-285262-690kpupt	129	4	by	by	IN
cord-285262-690kpupt	129	5	PAMP	PAMP	NNP
cord-285262-690kpupt	129	6	recognition	recognition	NN
cord-285262-690kpupt	129	7	receptors	receptor	NNS
cord-285262-690kpupt	129	8	(	(	-LRB-
cord-285262-690kpupt	129	9	PRR	PRR	NNP
cord-285262-690kpupt	129	10	)	)	-RRB-
cord-285262-690kpupt	130	1	(	(	-LRB-
cord-285262-690kpupt	130	2	Chow	Chow	NNP
cord-285262-690kpupt	130	3	et	et	FW
cord-285262-690kpupt	130	4	al	al	NNP
cord-285262-690kpupt	130	5	.	.	NNP
cord-285262-690kpupt	130	6	,	,	,
cord-285262-690kpupt	130	7	2015	2015	CD
cord-285262-690kpupt	130	8	)	)	-RRB-
cord-285262-690kpupt	130	9	,	,	,
cord-285262-690kpupt	130	10	which	which	WDT
cord-285262-690kpupt	130	11	mediate	mediate	VBP
cord-285262-690kpupt	130	12	the	the	DT
cord-285262-690kpupt	130	13	expression	expression	NN
cord-285262-690kpupt	130	14	and	and	CC
cord-285262-690kpupt	130	15	activation	activation	NN
cord-285262-690kpupt	130	16	of	of	IN
cord-285262-690kpupt	130	17	immunomodulatory	immunomodulatory	JJ
cord-285262-690kpupt	130	18	cytokines	cytokine	NNS
cord-285262-690kpupt	130	19	,	,	,
cord-285262-690kpupt	130	20	chemokines	chemokine	NNS
cord-285262-690kpupt	130	21	,	,	,
cord-285262-690kpupt	130	22	and	and	CC
cord-285262-690kpupt	130	23	interferons	interferon	NNS
cord-285262-690kpupt	130	24	.	.	.
cord-285262-690kpupt	131	1	Furthermore	furthermore	RB
cord-285262-690kpupt	131	2	,	,	,
cord-285262-690kpupt	131	3	the	the	DT
cord-285262-690kpupt	131	4	signaling	signaling	NN
cord-285262-690kpupt	131	5	through	through	IN
cord-285262-690kpupt	131	6	PRRs	prr	NNS
cord-285262-690kpupt	131	7	leads	lead	NNS
cord-285262-690kpupt	131	8	to	to	IN
cord-285262-690kpupt	131	9	cell	cell	NN
cord-285262-690kpupt	131	10	death	death	NN
cord-285262-690kpupt	131	11	signals	signal	NNS
cord-285262-690kpupt	131	12	primarily	primarily	RB
cord-285262-690kpupt	131	13	via	via	IN
cord-285262-690kpupt	131	14	the	the	DT
cord-285262-690kpupt	131	15	transcriptional	transcriptional	JJ
cord-285262-690kpupt	131	16	activation	activation	NN
cord-285262-690kpupt	131	17	of	of	IN
cord-285262-690kpupt	131	18	apoptotic	apoptotic	JJ
cord-285262-690kpupt	131	19	genes	gene	NNS
cord-285262-690kpupt	131	20	.	.	.
cord-285262-690kpupt	132	1	Depending	depend	VBG
cord-285262-690kpupt	132	2	on	on	IN
cord-285262-690kpupt	132	3	the	the	DT
cord-285262-690kpupt	132	4	spatial	spatial	JJ
cord-285262-690kpupt	132	5	localization	localization	NN
cord-285262-690kpupt	132	6	of	of	IN
cord-285262-690kpupt	132	7	the	the	DT
cord-285262-690kpupt	132	8	viral	viral	JJ
cord-285262-690kpupt	132	9	RNA	RNA	NNP
cord-285262-690kpupt	132	10	fragments	fragment	NNS
cord-285262-690kpupt	132	11	,	,	,
cord-285262-690kpupt	132	12	RNA	RNA	NNP
cord-285262-690kpupt	132	13	viruses	virus	NNS
cord-285262-690kpupt	132	14	can	can	MD
cord-285262-690kpupt	132	15	either	either	CC
cord-285262-690kpupt	132	16	stimulate	stimulate	VB
cord-285262-690kpupt	132	17	Toll	toll	NN
cord-285262-690kpupt	132	18	-	-	HYPH
cord-285262-690kpupt	132	19	like	like	JJ
cord-285262-690kpupt	132	20	receptors	receptor	NNS
cord-285262-690kpupt	132	21	(	(	-LRB-
cord-285262-690kpupt	132	22	TLRs	TLRs	NNP
cord-285262-690kpupt	132	23	)	)	-RRB-
cord-285262-690kpupt	132	24	or	or	CC
cord-285262-690kpupt	132	25	activate	activate	VB
cord-285262-690kpupt	132	26	the	the	DT
cord-285262-690kpupt	132	27	retinoic	retinoic	JJ
cord-285262-690kpupt	132	28	acid	acid	NN
cord-285262-690kpupt	132	29	inducible	inducible	JJ
cord-285262-690kpupt	132	30	gene	gene	NN
cord-285262-690kpupt	132	31	-	-	:
cord-285262-690kpupt	132	32	I	I	NNP
cord-285262-690kpupt	132	33	(	(	-LRB-
cord-285262-690kpupt	132	34	RIG	rig	NN
cord-285262-690kpupt	132	35	-	-	:
cord-285262-690kpupt	132	36	I	I	NNP
cord-285262-690kpupt	132	37	)	)	-RRB-
cord-285262-690kpupt	132	38	pathway	pathway	NN
cord-285262-690kpupt	132	39	.	.	.
cord-285262-690kpupt	133	1	TLR3	TLR3	NNP
cord-285262-690kpupt	133	2	,	,	,
cord-285262-690kpupt	133	3	which	which	WDT
cord-285262-690kpupt	133	4	resides	reside	VBZ
cord-285262-690kpupt	133	5	in	in	IN
cord-285262-690kpupt	133	6	the	the	DT
cord-285262-690kpupt	133	7	cytoplasmic	cytoplasmic	JJ
cord-285262-690kpupt	133	8	and	and	CC
cord-285262-690kpupt	133	9	endosomal	endosomal	JJ
cord-285262-690kpupt	133	10	membranes	membrane	NNS
cord-285262-690kpupt	133	11	(	(	-LRB-
cord-285262-690kpupt	133	12	Fig	Fig	NNP
cord-285262-690kpupt	133	13	.	.	.
cord-285262-690kpupt	133	14	1	1	CD
cord-285262-690kpupt	133	15	)	)	-RRB-
cord-285262-690kpupt	133	16	,	,	,
cord-285262-690kpupt	133	17	recognizes	recognize	VBZ
cord-285262-690kpupt	133	18	extracellular	extracellular	JJ
cord-285262-690kpupt	133	19	doublestranded	doublestranded	JJ
cord-285262-690kpupt	133	20	viral	viral	JJ
cord-285262-690kpupt	133	21	RNA	RNA	NNP
cord-285262-690kpupt	133	22	(	(	-LRB-
cord-285262-690kpupt	133	23	vRNA	vrna	JJ
cord-285262-690kpupt	133	24	)	)	-RRB-
cord-285262-690kpupt	133	25	fragments	fragment	NNS
cord-285262-690kpupt	133	26	(	(	-LRB-
cord-285262-690kpupt	133	27	Alexopoulou	Alexopoulou	NNP
cord-285262-690kpupt	133	28	et	et	NNP
cord-285262-690kpupt	133	29	al	al	NNP
cord-285262-690kpupt	133	30	.	.	NNP
cord-285262-690kpupt	133	31	,	,	,
cord-285262-690kpupt	133	32	2001	2001	CD
cord-285262-690kpupt	133	33	)	)	-RRB-
cord-285262-690kpupt	133	34	.	.	.
cord-285262-690kpupt	134	1	TLR3	TLR3	NNP
cord-285262-690kpupt	134	2	utilizes	utilize	VBZ
cord-285262-690kpupt	134	3	the	the	DT
cord-285262-690kpupt	134	4	adaptor	adaptor	NN
cord-285262-690kpupt	134	5	protein	protein	NN
cord-285262-690kpupt	134	6	Toll	Toll	NNP
cord-285262-690kpupt	134	7	/	/	SYM
cord-285262-690kpupt	134	8	interleukin-1	interleukin-1	NN
cord-285262-690kpupt	134	9	receptor	receptor	NN
cord-285262-690kpupt	134	10	(	(	-LRB-
cord-285262-690kpupt	134	11	TIR	TIR	NNP
cord-285262-690kpupt	134	12	)	)	-RRB-
cord-285262-690kpupt	134	13	domain	domain	NN
cord-285262-690kpupt	134	14	containing	contain	VBG
cord-285262-690kpupt	134	15	adaptor	adaptor	NN
cord-285262-690kpupt	134	16	inducing	induce	VBG
cord-285262-690kpupt	134	17	interferon	interferon	NN
cord-285262-690kpupt	134	18	(	(	-LRB-
cord-285262-690kpupt	134	19	TRIF	TRIF	NNP
cord-285262-690kpupt	134	20	)	)	-RRB-
cord-285262-690kpupt	135	1	(	(	-LRB-
cord-285262-690kpupt	135	2	Yamamoto	Yamamoto	NNP
cord-285262-690kpupt	135	3	et	et	NNP
cord-285262-690kpupt	135	4	al	al	NNP
cord-285262-690kpupt	135	5	.	.	NNP
cord-285262-690kpupt	135	6	,	,	,
cord-285262-690kpupt	135	7	2003	2003	CD
cord-285262-690kpupt	135	8	)	)	-RRB-
cord-285262-690kpupt	136	1	to	to	TO
cord-285262-690kpupt	136	2	recruit	recruit	VB
cord-285262-690kpupt	136	3	the	the	DT
cord-285262-690kpupt	136	4	inhibitor	inhibitor	NN
cord-285262-690kpupt	136	5	of	of	IN
cord-285262-690kpupt	136	6	kappa	kappa	NNP
cord-285262-690kpupt	136	7	B	B	NNP
cord-285262-690kpupt	136	8	kinase	kinase	NNP
cord-285262-690kpupt	136	9	(	(	-LRB-
cord-285262-690kpupt	136	10	IKK	IKK	NNP
cord-285262-690kpupt	136	11	)	)	-RRB-
cord-285262-690kpupt	136	12	,	,	,
cord-285262-690kpupt	136	13	subsequently	subsequently	RB
cord-285262-690kpupt	136	14	leading	lead	VBG
cord-285262-690kpupt	136	15	to	to	IN
cord-285262-690kpupt	136	16	the	the	DT
cord-285262-690kpupt	136	17	activation	activation	NN
cord-285262-690kpupt	136	18	of	of	IN
cord-285262-690kpupt	136	19	transcription	transcription	NN
cord-285262-690kpupt	136	20	factor	factor	NN
cord-285262-690kpupt	136	21	nuclear	nuclear	JJ
cord-285262-690kpupt	136	22	factor	factor	NN
cord-285262-690kpupt	136	23	kappa	kappa	NN
cord-285262-690kpupt	136	24	-	-	HYPH
cord-285262-690kpupt	136	25	light	light	JJ
cord-285262-690kpupt	136	26	-	-	HYPH
cord-285262-690kpupt	136	27	chain	chain	NN
cord-285262-690kpupt	136	28	-	-	HYPH
cord-285262-690kpupt	136	29	enhancer	enhancer	NN
cord-285262-690kpupt	136	30	of	of	IN
cord-285262-690kpupt	136	31	activated	activate	VBN
cord-285262-690kpupt	136	32	B	b	NN
cord-285262-690kpupt	136	33	cells	cell	NNS
cord-285262-690kpupt	136	34	(	(	-LRB-
cord-285262-690kpupt	136	35	NF	nf	NN
cord-285262-690kpupt	136	36	-	-	HYPH
cord-285262-690kpupt	136	37	κB	κB	NNP
cord-285262-690kpupt	136	38	)	)	-RRB-
cord-285262-690kpupt	136	39	and	and	CC
cord-285262-690kpupt	136	40	the	the	DT
cord-285262-690kpupt	136	41	TANK	tank	NN
cord-285262-690kpupt	136	42	binding	binding	NN
cord-285262-690kpupt	136	43	kinase	kinase	NN
cord-285262-690kpupt	136	44	1	1	CD
cord-285262-690kpupt	136	45	(	(	-LRB-
cord-285262-690kpupt	136	46	TBK1	TBK1	NNP
cord-285262-690kpupt	136	47	)	)	-RRB-
cord-285262-690kpupt	137	1	(	(	-LRB-
cord-285262-690kpupt	137	2	Fitzgerald	Fitzgerald	NNP
cord-285262-690kpupt	137	3	et	et	NNP
cord-285262-690kpupt	137	4	al	al	NNP
cord-285262-690kpupt	137	5	.	.	NNP
cord-285262-690kpupt	137	6	,	,	,
cord-285262-690kpupt	137	7	2003	2003	CD
cord-285262-690kpupt	137	8	)	)	-RRB-
cord-285262-690kpupt	137	9	,	,	,
cord-285262-690kpupt	137	10	which	which	WDT
cord-285262-690kpupt	137	11	in	in	IN
cord-285262-690kpupt	137	12	turn	turn	NN
cord-285262-690kpupt	137	13	induces	induce	VBZ
cord-285262-690kpupt	137	14	the	the	DT
cord-285262-690kpupt	137	15	interferon	interferon	NN
cord-285262-690kpupt	137	16	regulatory	regulatory	JJ
cord-285262-690kpupt	137	17	factor-3	factor-3	NNP
cord-285262-690kpupt	137	18	(	(	-LRB-
cord-285262-690kpupt	137	19	IRF3	IRF3	NNP
cord-285262-690kpupt	137	20	)	)	-RRB-
cord-285262-690kpupt	137	21	.	.	.
cord-285262-690kpupt	138	1	Intracellular	Intracellular	NNP
cord-285262-690kpupt	138	2	dsRNA	dsrna	NN
cord-285262-690kpupt	138	3	,	,	,
cord-285262-690kpupt	138	4	produced	produce	VBN
cord-285262-690kpupt	138	5	by	by	IN
cord-285262-690kpupt	138	6	replicating	replicate	VBG
cord-285262-690kpupt	138	7	viruses	virus	NNS
cord-285262-690kpupt	138	8	is	be	VBZ
cord-285262-690kpupt	138	9	detected	detect	VBN
cord-285262-690kpupt	138	10	by	by	IN
cord-285262-690kpupt	138	11	cytoplasmic	cytoplasmic	JJ
cord-285262-690kpupt	138	12	RNA	RNA	NNP
cord-285262-690kpupt	138	13	helicases	helicase	NNS
cord-285262-690kpupt	138	14	,	,	,
cord-285262-690kpupt	138	15	RIG	rig	NN
cord-285262-690kpupt	138	16	-	-	:
cord-285262-690kpupt	138	17	I	i	NN
cord-285262-690kpupt	138	18	and	and	CC
cord-285262-690kpupt	138	19	melanoma	melanoma	NN
cord-285262-690kpupt	138	20	differentiation	differentiation	NN
cord-285262-690kpupt	138	21	-	-	HYPH
cord-285262-690kpupt	138	22	associated	associate	VBN
cord-285262-690kpupt	138	23	gene	gene	NN
cord-285262-690kpupt	138	24	5	5	CD
cord-285262-690kpupt	138	25	(	(	-LRB-
cord-285262-690kpupt	138	26	MDA5	MDA5	NNP
cord-285262-690kpupt	138	27	)	)	-RRB-
cord-285262-690kpupt	139	1	(	(	-LRB-
cord-285262-690kpupt	139	2	Fig	Fig	NNP
cord-285262-690kpupt	139	3	.	.	NNP
cord-285262-690kpupt	139	4	1	1	CD
cord-285262-690kpupt	139	5	)	)	-RRB-
cord-285262-690kpupt	139	6	.	.	.
cord-285262-690kpupt	140	1	RIG	rig	NN
cord-285262-690kpupt	140	2	-	-	:
cord-285262-690kpupt	140	3	I	-PRON-	PRP
cord-285262-690kpupt	140	4	plays	play	VBZ
cord-285262-690kpupt	140	5	important	important	JJ
cord-285262-690kpupt	140	6	role	role	NN
cord-285262-690kpupt	140	7	in	in	IN
cord-285262-690kpupt	140	8	recognizing	recognize	VBG
cord-285262-690kpupt	140	9	RNAs	rna	NNS
cord-285262-690kpupt	140	10	from	from	IN
cord-285262-690kpupt	140	11	RNA	RNA	NNP
cord-285262-690kpupt	140	12	viruses	virus	NNS
cord-285262-690kpupt	140	13	,	,	,
cord-285262-690kpupt	140	14	including	include	VBG
cord-285262-690kpupt	140	15	Newcastle	Newcastle	NNP
cord-285262-690kpupt	140	16	disease	disease	NN
cord-285262-690kpupt	140	17	virus	virus	NN
cord-285262-690kpupt	140	18	(	(	-LRB-
cord-285262-690kpupt	140	19	NDV	NDV	NNP
cord-285262-690kpupt	140	20	)	)	-RRB-
cord-285262-690kpupt	140	21	,	,	,
cord-285262-690kpupt	140	22	Sendai	Sendai	NNP
cord-285262-690kpupt	140	23	virus	virus	NN
cord-285262-690kpupt	140	24	(	(	-LRB-
cord-285262-690kpupt	140	25	SeV	sev	NN
cord-285262-690kpupt	140	26	)	)	-RRB-
cord-285262-690kpupt	140	27	and	and	CC
cord-285262-690kpupt	140	28	Vesicular	Vesicular	NNP
cord-285262-690kpupt	140	29	stomatitis	stomatitis	NN
cord-285262-690kpupt	140	30	virus	virus	NN
cord-285262-690kpupt	140	31	(	(	-LRB-
cord-285262-690kpupt	140	32	VSV	VSV	NNP
cord-285262-690kpupt	140	33	)	)	-RRB-
cord-285262-690kpupt	141	1	(	(	-LRB-
cord-285262-690kpupt	141	2	Kato	Kato	NNP
cord-285262-690kpupt	141	3	et	et	NNP
cord-285262-690kpupt	141	4	al	al	NNP
cord-285262-690kpupt	141	5	.	.	NNP
cord-285262-690kpupt	141	6	,	,	,
cord-285262-690kpupt	141	7	2006	2006	CD
cord-285262-690kpupt	141	8	)	)	-RRB-
cord-285262-690kpupt	141	9	.	.	.
cord-285262-690kpupt	142	1	They	-PRON-	PRP
cord-285262-690kpupt	142	2	recruit	recruit	VBP
cord-285262-690kpupt	142	3	members	member	NNS
cord-285262-690kpupt	142	4	of	of	IN
cord-285262-690kpupt	142	5	the	the	DT
cord-285262-690kpupt	142	6	TRAF	TRAF	NNP
cord-285262-690kpupt	142	7	family	family	NN
cord-285262-690kpupt	142	8	via	via	IN
cord-285262-690kpupt	142	9	the	the	DT
cord-285262-690kpupt	142	10	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	142	11	anti	anti	JJ
cord-285262-690kpupt	142	12	-	-	JJ
cord-285262-690kpupt	142	13	viral	viral	JJ
cord-285262-690kpupt	142	14	-	-	HYPH
cord-285262-690kpupt	142	15	signaling	signal	VBG
cord-285262-690kpupt	142	16	protein	protein	NN
cord-285262-690kpupt	142	17	(	(	-LRB-
cord-285262-690kpupt	142	18	MAVS	MAVS	NNP
cord-285262-690kpupt	142	19	)	)	-RRB-
cord-285262-690kpupt	142	20	.	.	.
cord-285262-690kpupt	143	1	In	in	IN
cord-285262-690kpupt	143	2	turn	turn	NN
cord-285262-690kpupt	143	3	,	,	,
cord-285262-690kpupt	143	4	MAVS	mavs	UH
cord-285262-690kpupt	143	5	,	,	,
cord-285262-690kpupt	143	6	analogously	analogously	RB
cord-285262-690kpupt	143	7	to	to	IN
cord-285262-690kpupt	143	8	the	the	DT
cord-285262-690kpupt	143	9	TLR3	TLR3	NNP
cord-285262-690kpupt	143	10	pathway	pathway	NN
cord-285262-690kpupt	143	11	activates	activate	VBZ
cord-285262-690kpupt	143	12	the	the	DT
cord-285262-690kpupt	143	13	transcription	transcription	NN
cord-285262-690kpupt	143	14	factors	factor	NNS
cord-285262-690kpupt	143	15	IRF3	IRF3	NNP
cord-285262-690kpupt	143	16	and	and	CC
cord-285262-690kpupt	143	17	NF	nf	NN
cord-285262-690kpupt	143	18	-	-	HYPH
cord-285262-690kpupt	143	19	κB.	κb.	JJ
cord-285262-690kpupt	144	1	Importantly	importantly	RB
cord-285262-690kpupt	144	2	,	,	,
cord-285262-690kpupt	144	3	cells	cell	NNS
cord-285262-690kpupt	144	4	lacking	lack	VBG
cord-285262-690kpupt	144	5	the	the	DT
cord-285262-690kpupt	144	6	IRF3	IRF3	NNP
cord-285262-690kpupt	144	7	gene	gene	NN
cord-285262-690kpupt	144	8	are	be	VBP
cord-285262-690kpupt	144	9	not	not	RB
cord-285262-690kpupt	144	10	susceptible	susceptible	JJ
cord-285262-690kpupt	144	11	to	to	IN
cord-285262-690kpupt	144	12	apoptosis	apoptosis	NN
cord-285262-690kpupt	144	13	upon	upon	IN
cord-285262-690kpupt	144	14	SeV	sev	NN
cord-285262-690kpupt	144	15	infection	infection	NN
cord-285262-690kpupt	145	1	(	(	-LRB-
cord-285262-690kpupt	145	2	Peters	Peters	NNP
cord-285262-690kpupt	145	3	et	et	NNP
cord-285262-690kpupt	145	4	al	al	NNP
cord-285262-690kpupt	145	5	.	.	NNP
cord-285262-690kpupt	145	6	,	,	,
cord-285262-690kpupt	145	7	2008	2008	CD
cord-285262-690kpupt	145	8	)	)	-RRB-
cord-285262-690kpupt	145	9	.	.	.
cord-285262-690kpupt	146	1	Conversely	conversely	RB
cord-285262-690kpupt	146	2	,	,	,
cord-285262-690kpupt	146	3	MAVS	MAVS	NNP
cord-285262-690kpupt	146	4	is	be	VBZ
cord-285262-690kpupt	146	5	shown	show	VBN
cord-285262-690kpupt	146	6	to	to	TO
cord-285262-690kpupt	146	7	induce	induce	VB
cord-285262-690kpupt	146	8	apoptosis	apoptosis	NN
cord-285262-690kpupt	146	9	via	via	IN
cord-285262-690kpupt	146	10	caspase-8	caspase-8	NNP
cord-285262-690kpupt	147	1	but	but	CC
cord-285262-690kpupt	147	2	not	not	RB
cord-285262-690kpupt	147	3	via	via	IN
cord-285262-690kpupt	147	4	IRF3	IRF3	NNP
cord-285262-690kpupt	148	1	upon	upon	IN
cord-285262-690kpupt	148	2	Semliki	Semliki	NNP
cord-285262-690kpupt	148	3	Forest	Forest	NNP
cord-285262-690kpupt	148	4	virus	virus	NN
cord-285262-690kpupt	148	5	infection	infection	NN
cord-285262-690kpupt	149	1	(	(	-LRB-
cord-285262-690kpupt	149	2	El	El	NNP
cord-285262-690kpupt	149	3	Maadidi	Maadidi	NNP
cord-285262-690kpupt	149	4	et	et	NNP
cord-285262-690kpupt	149	5	al	al	NNP
cord-285262-690kpupt	149	6	.	.	NNP
cord-285262-690kpupt	149	7	,	,	,
cord-285262-690kpupt	149	8	2014	2014	CD
cord-285262-690kpupt	149	9	)	)	-RRB-
cord-285262-690kpupt	149	10	.	.	.
cord-285262-690kpupt	150	1	Infection	infection	NN
cord-285262-690kpupt	150	2	of	of	IN
cord-285262-690kpupt	150	3	a	a	DT
cord-285262-690kpupt	150	4	genetically	genetically	RB
cord-285262-690kpupt	150	5	engineered	engineer	VBN
cord-285262-690kpupt	150	6	Vaccinia	vaccinia	NN
cord-285262-690kpupt	150	7	virus	virus	NN
cord-285262-690kpupt	150	8	strain	strain	NN
cord-285262-690kpupt	150	9	,	,	,
cord-285262-690kpupt	150	10	lacking	lack	VBG
cord-285262-690kpupt	150	11	the	the	DT
cord-285262-690kpupt	150	12	viral	viral	JJ
cord-285262-690kpupt	150	13	BCL-2	BCL-2	NNP
cord-285262-690kpupt	150	14	analog	analog	JJ
cord-285262-690kpupt	151	1	F1L	F1L	NNP
cord-285262-690kpupt	151	2	protein	protein	NN
cord-285262-690kpupt	151	3	induces	induce	VBZ
cord-285262-690kpupt	151	4	apoptosis	apoptosis	NN
cord-285262-690kpupt	151	5	via	via	IN
cord-285262-690kpupt	151	6	the	the	DT
cord-285262-690kpupt	151	7	activation	activation	NN
cord-285262-690kpupt	151	8	of	of	IN
cord-285262-690kpupt	151	9	IRF3	IRF3	NNP
cord-285262-690kpupt	151	10	,	,	,
cord-285262-690kpupt	151	11	which	which	WDT
cord-285262-690kpupt	151	12	in	in	IN
cord-285262-690kpupt	151	13	turn	turn	NN
cord-285262-690kpupt	151	14	mediates	mediate	VBZ
cord-285262-690kpupt	151	15	the	the	DT
cord-285262-690kpupt	151	16	expression	expression	NN
cord-285262-690kpupt	151	17	of	of	IN
cord-285262-690kpupt	151	18	the	the	DT
cord-285262-690kpupt	151	19	pro	pro	JJ
cord-285262-690kpupt	151	20	-	-	JJ
cord-285262-690kpupt	151	21	apoptotic	apoptotic	JJ
cord-285262-690kpupt	151	22	protein	protein	NN
cord-285262-690kpupt	151	23	Noxa	Noxa	NNP
cord-285262-690kpupt	151	24	(	(	-LRB-
cord-285262-690kpupt	151	25	from	from	IN
cord-285262-690kpupt	151	26	Latin	Latin	NNP
cord-285262-690kpupt	151	27	:	:	:
cord-285262-690kpupt	151	28	"	"	``
cord-285262-690kpupt	151	29	damage	damage	NN
cord-285262-690kpupt	151	30	"	"	''
cord-285262-690kpupt	151	31	)	)	-RRB-
cord-285262-690kpupt	151	32	in	in	IN
cord-285262-690kpupt	151	33	monocytes	monocyte	NNS
cord-285262-690kpupt	151	34	and	and	CC
cord-285262-690kpupt	151	35	lymphocytes	lymphocyte	NNS
cord-285262-690kpupt	152	1	(	(	-LRB-
cord-285262-690kpupt	152	2	Eitz	Eitz	NNP
cord-285262-690kpupt	152	3	Ferrer	Ferrer	NNP
cord-285262-690kpupt	152	4	et	et	NNP
cord-285262-690kpupt	152	5	al	al	NNP
cord-285262-690kpupt	152	6	.	.	NNP
cord-285262-690kpupt	152	7	,	,	,
cord-285262-690kpupt	152	8	2011	2011	CD
cord-285262-690kpupt	152	9	)	)	-RRB-
cord-285262-690kpupt	152	10	,	,	,
cord-285262-690kpupt	152	11	whereas	whereas	IN
cord-285262-690kpupt	152	12	the	the	DT
cord-285262-690kpupt	152	13	wild	wild	JJ
cord-285262-690kpupt	152	14	type	type	NN
cord-285262-690kpupt	152	15	strain	strain	NN
cord-285262-690kpupt	152	16	,	,	,
cord-285262-690kpupt	152	17	possessing	possess	VBG
cord-285262-690kpupt	152	18	the	the	DT
cord-285262-690kpupt	152	19	F1L	f1l	JJ
cord-285262-690kpupt	152	20	protein	protein	NN
cord-285262-690kpupt	152	21	can	can	MD
cord-285262-690kpupt	152	22	not	not	RB
cord-285262-690kpupt	152	23	stimulate	stimulate	VB
cord-285262-690kpupt	152	24	the	the	DT
cord-285262-690kpupt	152	25	same	same	JJ
cord-285262-690kpupt	152	26	response	response	NN
cord-285262-690kpupt	152	27	,	,	,
cord-285262-690kpupt	152	28	indicating	indicate	VBG
cord-285262-690kpupt	152	29	that	that	IN
cord-285262-690kpupt	152	30	the	the	DT
cord-285262-690kpupt	152	31	Vaccinia	Vaccinia	NNP
cord-285262-690kpupt	152	32	virus	virus	NN
cord-285262-690kpupt	152	33	successfully	successfully	RB
cord-285262-690kpupt	152	34	adapted	adapt	VBN
cord-285262-690kpupt	152	35	in	in	IN
cord-285262-690kpupt	152	36	an	an	DT
cord-285262-690kpupt	152	37	evolutionary	evolutionary	JJ
cord-285262-690kpupt	152	38	race	race	NN
cord-285262-690kpupt	152	39	to	to	TO
cord-285262-690kpupt	152	40	overcome	overcome	VB
cord-285262-690kpupt	152	41	the	the	DT
cord-285262-690kpupt	152	42	apoptotic	apoptotic	JJ
cord-285262-690kpupt	152	43	inducing	induce	VBG
cord-285262-690kpupt	152	44	capacity	capacity	NN
cord-285262-690kpupt	152	45	of	of	IN
cord-285262-690kpupt	152	46	the	the	DT
cord-285262-690kpupt	152	47	host	host	NN
cord-285262-690kpupt	152	48	.	.	.
cord-285262-690kpupt	153	1	It	-PRON-	PRP
cord-285262-690kpupt	153	2	was	be	VBD
cord-285262-690kpupt	153	3	recognized	recognize	VBN
cord-285262-690kpupt	153	4	that	that	IN
cord-285262-690kpupt	153	5	TLR3	TLR3	NNP
cord-285262-690kpupt	153	6	stimulation	stimulation	NN
cord-285262-690kpupt	153	7	was	be	VBD
cord-285262-690kpupt	153	8	able	able	JJ
cord-285262-690kpupt	153	9	to	to	TO
cord-285262-690kpupt	153	10	trigger	trigger	VB
cord-285262-690kpupt	153	11	apoptosis	apoptosis	NN
cord-285262-690kpupt	153	12	via	via	IN
cord-285262-690kpupt	153	13	the	the	DT
cord-285262-690kpupt	153	14	adaptor	adaptor	NN
cord-285262-690kpupt	153	15	protein	protein	NN
cord-285262-690kpupt	153	16	TRIF	TRIF	NNP
cord-285262-690kpupt	153	17	(	(	-LRB-
cord-285262-690kpupt	153	18	Kaiser	Kaiser	NNP
cord-285262-690kpupt	153	19	and	and	CC
cord-285262-690kpupt	153	20	Offermann	Offermann	NNP
cord-285262-690kpupt	153	21	,	,	,
cord-285262-690kpupt	153	22	2005	2005	CD
cord-285262-690kpupt	153	23	)	)	-RRB-
cord-285262-690kpupt	153	24	and	and	CC
cord-285262-690kpupt	153	25	that	that	IN
cord-285262-690kpupt	153	26	TLR3	TLR3	NNP
cord-285262-690kpupt	153	27	mediated	mediate	VBD
cord-285262-690kpupt	153	28	direct	direct	JJ
cord-285262-690kpupt	153	29	caspase-8	caspase-8	NNP
cord-285262-690kpupt	153	30	activation	activation	NN
cord-285262-690kpupt	153	31	,	,	,
cord-285262-690kpupt	153	32	primarily	primarily	RB
cord-285262-690kpupt	153	33	depending	depend	VBG
cord-285262-690kpupt	153	34	on	on	IN
cord-285262-690kpupt	153	35	the	the	DT
cord-285262-690kpupt	153	36	presence	presence	NN
cord-285262-690kpupt	153	37	of	of	IN
cord-285262-690kpupt	153	38	cFLIP	cFLIP	NNP
cord-285262-690kpupt	153	39	isoforms	isoform	NNS
cord-285262-690kpupt	154	1	(	(	-LRB-
cord-285262-690kpupt	154	2	Feoktistova	Feoktistova	NNP
cord-285262-690kpupt	154	3	et	et	NNP
cord-285262-690kpupt	154	4	al	al	NNP
cord-285262-690kpupt	154	5	.	.	NNP
cord-285262-690kpupt	154	6	,	,	,
cord-285262-690kpupt	154	7	2011	2011	CD
cord-285262-690kpupt	154	8	;	;	:
cord-285262-690kpupt	154	9	Weber	Weber	NNP
cord-285262-690kpupt	154	10	et	et	NNP
cord-285262-690kpupt	154	11	al	al	NNP
cord-285262-690kpupt	154	12	.	.	NNP
cord-285262-690kpupt	154	13	,	,	,
cord-285262-690kpupt	154	14	2010	2010	CD
cord-285262-690kpupt	154	15	)	)	-RRB-
cord-285262-690kpupt	154	16	.	.	.
cord-285262-690kpupt	155	1	Along	along	IN
cord-285262-690kpupt	155	2	with	with	IN
cord-285262-690kpupt	155	3	this	this	DT
cord-285262-690kpupt	155	4	,	,	,
cord-285262-690kpupt	155	5	immunoprecipitation	immunoprecipitation	NN
cord-285262-690kpupt	155	6	experiments	experiment	NNS
cord-285262-690kpupt	155	7	of	of	IN
cord-285262-690kpupt	155	8	TLR3	TLR3	NNP
cord-285262-690kpupt	155	9	demonstrate	demonstrate	VBP
cord-285262-690kpupt	155	10	the	the	DT
cord-285262-690kpupt	155	11	formation	formation	NN
cord-285262-690kpupt	155	12	of	of	IN
cord-285262-690kpupt	155	13	a	a	DT
cord-285262-690kpupt	155	14	TLR3	TLR3	NNP
cord-285262-690kpupt	155	15	associated	associate	VBN
cord-285262-690kpupt	155	16	DISC	DISC	NNP
cord-285262-690kpupt	155	17	-	-	HYPH
cord-285262-690kpupt	155	18	like	like	JJ
cord-285262-690kpupt	155	19	complex	complex	NN
cord-285262-690kpupt	155	20	,	,	,
cord-285262-690kpupt	155	21	including	include	VBG
cord-285262-690kpupt	155	22	TRIF	TRIF	NNP
cord-285262-690kpupt	155	23	,	,	,
cord-285262-690kpupt	155	24	RIPK1	RIPK1	NNP
cord-285262-690kpupt	155	25	,	,	,
cord-285262-690kpupt	155	26	FADD	FADD	NNP
cord-285262-690kpupt	155	27	,	,	,
cord-285262-690kpupt	155	28	cFLIP	cFLIP	NNP
cord-285262-690kpupt	155	29	and	and	CC
cord-285262-690kpupt	155	30	caspase-8	caspase-8	NNP
cord-285262-690kpupt	156	1	in	in	IN
cord-285262-690kpupt	156	2	response	response	NN
cord-285262-690kpupt	156	3	to	to	IN
cord-285262-690kpupt	156	4	IAV	IAV	NNP
cord-285262-690kpupt	156	5	infection	infection	NN
cord-285262-690kpupt	156	6	.	.	.
cord-285262-690kpupt	157	1	The	the	DT
cord-285262-690kpupt	157	2	administration	administration	NN
cord-285262-690kpupt	157	3	of	of	IN
cord-285262-690kpupt	157	4	interleukin-24	interleukin-24	NNP
cord-285262-690kpupt	157	5	(	(	-LRB-
cord-285262-690kpupt	157	6	IL-24	IL-24	NNP
cord-285262-690kpupt	157	7	)	)	-RRB-
cord-285262-690kpupt	157	8	facilitates	facilitate	VBZ
cord-285262-690kpupt	157	9	the	the	DT
cord-285262-690kpupt	157	10	caspase-8	caspase-8	NNP
cord-285262-690kpupt	157	11	activation	activation	NN
cord-285262-690kpupt	157	12	by	by	IN
cord-285262-690kpupt	157	13	decreasing	decrease	VBG
cord-285262-690kpupt	157	14	the	the	DT
cord-285262-690kpupt	157	15	presence	presence	NN
cord-285262-690kpupt	157	16	of	of	IN
cord-285262-690kpupt	157	17	cFLIP	cFLIP	NNP
cord-285262-690kpupt	157	18	in	in	IN
cord-285262-690kpupt	157	19	the	the	DT
cord-285262-690kpupt	157	20	complex	complex	NN
cord-285262-690kpupt	157	21	and	and	CC
cord-285262-690kpupt	157	22	renders	render	VBZ
cord-285262-690kpupt	157	23	the	the	DT
cord-285262-690kpupt	157	24	cells	cell	NNS
cord-285262-690kpupt	157	25	to	to	IN
cord-285262-690kpupt	157	26	apoptosis	apoptosis	NN
cord-285262-690kpupt	157	27	(	(	-LRB-
cord-285262-690kpupt	157	28	Weiss	Weiss	NNP
cord-285262-690kpupt	157	29	et	et	NNP
cord-285262-690kpupt	157	30	al	al	NNP
cord-285262-690kpupt	157	31	.	.	NNP
cord-285262-690kpupt	157	32	,	,	,
cord-285262-690kpupt	157	33	2013	2013	CD
cord-285262-690kpupt	157	34	)	)	-RRB-
cord-285262-690kpupt	157	35	.	.	.
cord-285262-690kpupt	158	1	The	the	DT
cord-285262-690kpupt	158	2	relevance	relevance	NN
cord-285262-690kpupt	158	3	of	of	IN
cord-285262-690kpupt	158	4	TLR-3	TLR-3	NNP
cord-285262-690kpupt	158	5	/	/	SYM
cord-285262-690kpupt	158	6	caspase-8	caspase-8	NNP
cord-285262-690kpupt	158	7	dependent	dependent	JJ
cord-285262-690kpupt	158	8	apoptosis	apoptosis	NN
cord-285262-690kpupt	158	9	is	be	VBZ
cord-285262-690kpupt	158	10	further	further	RB
cord-285262-690kpupt	158	11	confirmed	confirm	VBN
cord-285262-690kpupt	158	12	in	in	IN
cord-285262-690kpupt	158	13	mouse	mouse	NN
cord-285262-690kpupt	158	14	intestinal	intestinal	JJ
cord-285262-690kpupt	158	15	epithelial	epithelial	JJ
cord-285262-690kpupt	158	16	cells	cell	NNS
cord-285262-690kpupt	158	17	,	,	,
cord-285262-690kpupt	158	18	where	where	WRB
cord-285262-690kpupt	158	19	the	the	DT
cord-285262-690kpupt	158	20	apoptosis	apoptosis	NN
cord-285262-690kpupt	158	21	is	be	VBZ
cord-285262-690kpupt	158	22	independent	independent	JJ
cord-285262-690kpupt	158	23	from	from	IN
cord-285262-690kpupt	158	24	the	the	DT
cord-285262-690kpupt	158	25	TNFR	TNFR	NNP
cord-285262-690kpupt	158	26	signaling	signal	VBG
cord-285262-690kpupt	158	27	and	and	CC
cord-285262-690kpupt	158	28	from	from	IN
cord-285262-690kpupt	158	29	the	the	DT
cord-285262-690kpupt	158	30	effect	effect	NN
cord-285262-690kpupt	158	31	of	of	IN
cord-285262-690kpupt	158	32	external	external	JJ
cord-285262-690kpupt	158	33	cytokines	cytokine	NNS
cord-285262-690kpupt	158	34	(	(	-LRB-
cord-285262-690kpupt	158	35	McAllister	McAllister	NNP
cord-285262-690kpupt	158	36	et	et	NNP
cord-285262-690kpupt	158	37	al	al	NNP
cord-285262-690kpupt	158	38	.	.	NNP
cord-285262-690kpupt	158	39	,	,	,
cord-285262-690kpupt	158	40	2013	2013	CD
cord-285262-690kpupt	158	41	)	)	-RRB-
cord-285262-690kpupt	158	42	.	.	.
cord-285262-690kpupt	159	1	The	the	DT
cord-285262-690kpupt	159	2	cyclic	cyclic	JJ
cord-285262-690kpupt	159	3	GMP	GMP	NNP
cord-285262-690kpupt	159	4	-	-	HYPH
cord-285262-690kpupt	159	5	AMP	AMP	NNP
cord-285262-690kpupt	159	6	(	(	-LRB-
cord-285262-690kpupt	159	7	cGAMP	cGAMP	NNP
cord-285262-690kpupt	159	8	)	)	-RRB-
cord-285262-690kpupt	159	9	synthase	synthase	NN
cord-285262-690kpupt	159	10	(	(	-LRB-
cord-285262-690kpupt	159	11	cGAS	cGAS	NNP
cord-285262-690kpupt	159	12	)	)	-RRB-
cord-285262-690kpupt	159	13	has	have	VBZ
cord-285262-690kpupt	159	14	been	be	VBN
cord-285262-690kpupt	159	15	shown	show	VBN
cord-285262-690kpupt	159	16	to	to	TO
cord-285262-690kpupt	159	17	interact	interact	VB
cord-285262-690kpupt	159	18	with	with	IN
cord-285262-690kpupt	159	19	viral	viral	JJ
cord-285262-690kpupt	159	20	DNA	dna	NN
cord-285262-690kpupt	159	21	(	(	-LRB-
cord-285262-690kpupt	159	22	vDNA	vdna	NN
cord-285262-690kpupt	159	23	)	)	-RRB-
cord-285262-690kpupt	159	24	molecules	molecule	NNS
cord-285262-690kpupt	159	25	.	.	.
cord-285262-690kpupt	160	1	Upon	upon	IN
cord-285262-690kpupt	160	2	interaction	interaction	NN
cord-285262-690kpupt	160	3	,	,	,
cord-285262-690kpupt	160	4	cGAS	cGAS	NNP
cord-285262-690kpupt	160	5	produces	produce	VBZ
cord-285262-690kpupt	160	6	its	-PRON-	PRP$
cord-285262-690kpupt	160	7	second	second	JJ
cord-285262-690kpupt	160	8	messenger	messenger	NN
cord-285262-690kpupt	160	9	cGAMP	cGAMP	NNP
cord-285262-690kpupt	161	1	and	and	CC
cord-285262-690kpupt	161	2	this	this	DT
cord-285262-690kpupt	161	3	in	in	IN
cord-285262-690kpupt	161	4	turn	turn	NN
cord-285262-690kpupt	161	5	activates	activate	VBZ
cord-285262-690kpupt	161	6	the	the	DT
cord-285262-690kpupt	161	7	stimulator	stimulator	NN
cord-285262-690kpupt	161	8	of	of	IN
cord-285262-690kpupt	161	9	interferon	interferon	NN
cord-285262-690kpupt	161	10	gene	gene	NN
cord-285262-690kpupt	161	11	(	(	-LRB-
cord-285262-690kpupt	161	12	STING	sting	NN
cord-285262-690kpupt	161	13	)	)	-RRB-
cord-285262-690kpupt	161	14	protein	protein	NN
cord-285262-690kpupt	161	15	(	(	-LRB-
cord-285262-690kpupt	161	16	Fig	Fig	NNP
cord-285262-690kpupt	161	17	.	.	.
cord-285262-690kpupt	161	18	1	1	CD
cord-285262-690kpupt	161	19	)	)	-RRB-
cord-285262-690kpupt	161	20	,	,	,
cord-285262-690kpupt	161	21	which	which	WDT
cord-285262-690kpupt	161	22	is	be	VBZ
cord-285262-690kpupt	161	23	located	locate	VBN
cord-285262-690kpupt	161	24	in	in	IN
cord-285262-690kpupt	161	25	the	the	DT
cord-285262-690kpupt	161	26	endoplasmic	endoplasmic	NN
cord-285262-690kpupt	161	27	reticulum	reticulum	NN
cord-285262-690kpupt	161	28	(	(	-LRB-
cord-285262-690kpupt	161	29	ER	ER	NNP
cord-285262-690kpupt	161	30	)	)	-RRB-
cord-285262-690kpupt	161	31	.	.	.
cord-285262-690kpupt	162	1	Consequently	consequently	RB
cord-285262-690kpupt	162	2	,	,	,
cord-285262-690kpupt	162	3	STING	STING	NNP
cord-285262-690kpupt	162	4	can	can	MD
cord-285262-690kpupt	162	5	activate	activate	VB
cord-285262-690kpupt	162	6	IRF3	IRF3	NNP
cord-285262-690kpupt	163	1	(	(	-LRB-
cord-285262-690kpupt	163	2	Ishikawa	Ishikawa	NNP
cord-285262-690kpupt	163	3	and	and	CC
cord-285262-690kpupt	163	4	Barber	Barber	NNP
cord-285262-690kpupt	163	5	,	,	,
cord-285262-690kpupt	163	6	2008	2008	CD
cord-285262-690kpupt	163	7	;	;	:
cord-285262-690kpupt	163	8	Sun	Sun	NNP
cord-285262-690kpupt	163	9	et	et	NNP
cord-285262-690kpupt	163	10	al	al	NNP
cord-285262-690kpupt	163	11	.	.	NNP
cord-285262-690kpupt	163	12	,	,	,
cord-285262-690kpupt	163	13	2013	2013	CD
cord-285262-690kpupt	163	14	)	)	-RRB-
cord-285262-690kpupt	163	15	and	and	CC
cord-285262-690kpupt	163	16	result	result	VB
cord-285262-690kpupt	163	17	in	in	IN
cord-285262-690kpupt	163	18	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	163	19	apoptosis	apoptosis	NN
cord-285262-690kpupt	163	20	(	(	-LRB-
cord-285262-690kpupt	163	21	Diner	Diner	NNP
cord-285262-690kpupt	163	22	et	et	NNP
cord-285262-690kpupt	163	23	al	al	NNP
cord-285262-690kpupt	163	24	.	.	NNP
cord-285262-690kpupt	163	25	,	,	,
cord-285262-690kpupt	163	26	2016	2016	CD
cord-285262-690kpupt	163	27	)	)	-RRB-
cord-285262-690kpupt	163	28	.	.	.
cord-285262-690kpupt	164	1	Intriguingly	intriguingly	RB
cord-285262-690kpupt	164	2	,	,	,
cord-285262-690kpupt	164	3	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	164	4	DNA	dna	NN
cord-285262-690kpupt	164	5	(	(	-LRB-
cord-285262-690kpupt	164	6	mtDNA	mtDNA	NNP
cord-285262-690kpupt	164	7	)	)	-RRB-
cord-285262-690kpupt	164	8	that	that	WDT
cord-285262-690kpupt	164	9	is	be	VBZ
cord-285262-690kpupt	164	10	released	release	VBN
cord-285262-690kpupt	164	11	upon	upon	IN
cord-285262-690kpupt	164	12	the	the	DT
cord-285262-690kpupt	164	13	apoptotic	apoptotic	JJ
cord-285262-690kpupt	164	14	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	164	15	membrane	membrane	NN
cord-285262-690kpupt	164	16	permeabilization	permeabilization	NN
cord-285262-690kpupt	164	17	can	can	MD
cord-285262-690kpupt	164	18	also	also	RB
cord-285262-690kpupt	164	19	activate	activate	VB
cord-285262-690kpupt	164	20	cGAS	cgas	NN
cord-285262-690kpupt	164	21	.	.	.
cord-285262-690kpupt	165	1	This	this	DT
cord-285262-690kpupt	165	2	can	can	MD
cord-285262-690kpupt	165	3	trigger	trigger	VB
cord-285262-690kpupt	165	4	IRF3	IRF3	NNP
cord-285262-690kpupt	165	5	activation	activation	NN
cord-285262-690kpupt	165	6	and	and	CC
cord-285262-690kpupt	165	7	consequently	consequently	RB
cord-285262-690kpupt	165	8	result	result	VB
cord-285262-690kpupt	165	9	in	in	IN
cord-285262-690kpupt	165	10	anti	anti	JJ
cord-285262-690kpupt	165	11	-	-	JJ
cord-285262-690kpupt	165	12	viral	viral	JJ
cord-285262-690kpupt	165	13	responses	response	NNS
cord-285262-690kpupt	165	14	even	even	RB
cord-285262-690kpupt	165	15	in	in	IN
cord-285262-690kpupt	165	16	circumstances	circumstance	NNS
cord-285262-690kpupt	165	17	where	where	WRB
cord-285262-690kpupt	165	18	viruses	virus	NNS
cord-285262-690kpupt	165	19	efficiently	efficiently	RB
cord-285262-690kpupt	165	20	block	block	VBP
cord-285262-690kpupt	165	21	apoptosis	apoptosis	NN
cord-285262-690kpupt	165	22	downstream	downstream	RB
cord-285262-690kpupt	165	23	of	of	IN
cord-285262-690kpupt	165	24	MOMP	MOMP	NNP
cord-285262-690kpupt	165	25	,	,	,
cord-285262-690kpupt	165	26	for	for	IN
cord-285262-690kpupt	165	27	example	example	NN
cord-285262-690kpupt	165	28	at	at	IN
cord-285262-690kpupt	165	29	the	the	DT
cord-285262-690kpupt	165	30	level	level	NN
cord-285262-690kpupt	165	31	of	of	IN
cord-285262-690kpupt	165	32	caspase	caspase	NN
cord-285262-690kpupt	165	33	activation	activation	NN
cord-285262-690kpupt	165	34	.	.	.
cord-285262-690kpupt	166	1	It	-PRON-	PRP
cord-285262-690kpupt	166	2	has	have	VBZ
cord-285262-690kpupt	166	3	been	be	VBN
cord-285262-690kpupt	166	4	demonstrated	demonstrate	VBN
cord-285262-690kpupt	166	5	that	that	IN
cord-285262-690kpupt	166	6	apoptotic	apoptotic	JJ
cord-285262-690kpupt	166	7	caspases	caspase	NNS
cord-285262-690kpupt	166	8	not	not	RB
cord-285262-690kpupt	166	9	only	only	RB
cord-285262-690kpupt	166	10	mediate	mediate	VBP
cord-285262-690kpupt	166	11	an	an	DT
cord-285262-690kpupt	166	12	anti	anti	JJ
cord-285262-690kpupt	166	13	-	-	JJ
cord-285262-690kpupt	166	14	inflammatory	inflammatory	JJ
cord-285262-690kpupt	166	15	cell	cell	NN
cord-285262-690kpupt	166	16	death	death	NN
cord-285262-690kpupt	166	17	pathway	pathway	NN
cord-285262-690kpupt	166	18	,	,	,
cord-285262-690kpupt	166	19	but	but	CC
cord-285262-690kpupt	166	20	also	also	RB
cord-285262-690kpupt	166	21	directly	directly	RB
cord-285262-690kpupt	166	22	block	block	VB
cord-285262-690kpupt	166	23	the	the	DT
cord-285262-690kpupt	166	24	mtDNA	mtdna	NN
cord-285262-690kpupt	166	25	triggered	trigger	VBD
cord-285262-690kpupt	166	26	STING	sting	NN
cord-285262-690kpupt	166	27	-	-	HYPH
cord-285262-690kpupt	166	28	mediated	mediate	VBN
cord-285262-690kpupt	166	29	IFN	IFN	NNP
cord-285262-690kpupt	166	30	production	production	NN
cord-285262-690kpupt	166	31	in	in	IN
cord-285262-690kpupt	166	32	mice	mouse	NNS
cord-285262-690kpupt	166	33	(	(	-LRB-
cord-285262-690kpupt	166	34	White	White	NNP
cord-285262-690kpupt	166	35	et	et	FW
cord-285262-690kpupt	166	36	al	al	NNP
cord-285262-690kpupt	166	37	.	.	NNP
cord-285262-690kpupt	166	38	,	,	,
cord-285262-690kpupt	166	39	2014	2014	CD
cord-285262-690kpupt	166	40	)	)	-RRB-
cord-285262-690kpupt	166	41	.	.	.
cord-285262-690kpupt	167	1	A	a	DT
cord-285262-690kpupt	167	2	recent	recent	JJ
cord-285262-690kpupt	167	3	study	study	NN
cord-285262-690kpupt	167	4	provides	provide	VBZ
cord-285262-690kpupt	167	5	evidence	evidence	NN
cord-285262-690kpupt	167	6	that	that	IN
cord-285262-690kpupt	167	7	apoptotic	apoptotic	JJ
cord-285262-690kpupt	167	8	caspases	caspase	NNS
cord-285262-690kpupt	167	9	cleave	cleave	VBP
cord-285262-690kpupt	167	10	the	the	DT
cord-285262-690kpupt	167	11	cytoplasmic	cytoplasmic	JJ
cord-285262-690kpupt	167	12	anti	anti	JJ
cord-285262-690kpupt	167	13	-	-	JJ
cord-285262-690kpupt	167	14	viral	viral	JJ
cord-285262-690kpupt	167	15	sensors	sensor	NNS
cord-285262-690kpupt	167	16	cGAS	cgas	JJ
cord-285262-690kpupt	167	17	,	,	,
cord-285262-690kpupt	167	18	MAVS	MAVS	NNP
cord-285262-690kpupt	167	19	and	and	CC
cord-285262-690kpupt	167	20	IRF3	IRF3	NNP
cord-285262-690kpupt	167	21	to	to	TO
cord-285262-690kpupt	167	22	limit	limit	VB
cord-285262-690kpupt	167	23	cytokine	cytokine	JJ
cord-285262-690kpupt	167	24	production	production	NN
cord-285262-690kpupt	167	25	.	.	.
cord-285262-690kpupt	168	1	In	in	IN
cord-285262-690kpupt	168	2	this	this	DT
cord-285262-690kpupt	168	3	study	study	NN
cord-285262-690kpupt	168	4	caspase-3	caspase-3	NNP
cord-285262-690kpupt	168	5	deficient	deficient	JJ
cord-285262-690kpupt	168	6	mice	mice	NN
cord-285262-690kpupt	168	7	exerts	exert	VBZ
cord-285262-690kpupt	168	8	increased	increase	VBN
cord-285262-690kpupt	168	9	resistance	resistance	NN
cord-285262-690kpupt	168	10	to	to	IN
cord-285262-690kpupt	168	11	virus	virus	NN
cord-285262-690kpupt	168	12	infection	infection	NN
cord-285262-690kpupt	168	13	,	,	,
cord-285262-690kpupt	168	14	suggesting	suggest	VBG
cord-285262-690kpupt	168	15	that	that	IN
cord-285262-690kpupt	168	16	caspase	caspase	NN
cord-285262-690kpupt	168	17	activation	activation	NN
cord-285262-690kpupt	168	18	may	may	MD
cord-285262-690kpupt	168	19	contribute	contribute	VB
cord-285262-690kpupt	168	20	to	to	IN
cord-285262-690kpupt	168	21	virus	virus	NN
cord-285262-690kpupt	168	22	propagation	propagation	NN
cord-285262-690kpupt	168	23	by	by	IN
cord-285262-690kpupt	168	24	cutting	cut	VBG
cord-285262-690kpupt	168	25	off	off	RP
cord-285262-690kpupt	168	26	the	the	DT
cord-285262-690kpupt	168	27	pro	pro	JJ
cord-285262-690kpupt	168	28	-	-	JJ
cord-285262-690kpupt	168	29	inflammatory	inflammatory	JJ
cord-285262-690kpupt	168	30	signals	signal	NNS
cord-285262-690kpupt	168	31	deriving	derive	VBG
cord-285262-690kpupt	168	32	from	from	IN
cord-285262-690kpupt	168	33	the	the	DT
cord-285262-690kpupt	168	34	infected	infected	JJ
cord-285262-690kpupt	168	35	cells	cell	NNS
cord-285262-690kpupt	168	36	(	(	-LRB-
cord-285262-690kpupt	168	37	Ning	Ning	NNP
cord-285262-690kpupt	168	38	et	et	FW
cord-285262-690kpupt	168	39	al	al	NNP
cord-285262-690kpupt	168	40	.	.	NNP
cord-285262-690kpupt	168	41	,	,	,
cord-285262-690kpupt	168	42	2019	2019	CD
cord-285262-690kpupt	168	43	)	)	-RRB-
cord-285262-690kpupt	168	44	.	.	.
cord-285262-690kpupt	169	1	The	the	DT
cord-285262-690kpupt	169	2	viruses	virus	NNS
cord-285262-690kpupt	169	3	developed	develop	VBD
cord-285262-690kpupt	169	4	elaborate	elaborate	JJ
cord-285262-690kpupt	169	5	countermeasures	countermeasure	NNS
cord-285262-690kpupt	169	6	to	to	TO
cord-285262-690kpupt	169	7	avoid	avoid	VB
cord-285262-690kpupt	169	8	or	or	CC
cord-285262-690kpupt	169	9	delay	delay	VB
cord-285262-690kpupt	169	10	a	a	DT
cord-285262-690kpupt	169	11	premature	premature	JJ
cord-285262-690kpupt	169	12	apoptotic	apoptotic	JJ
cord-285262-690kpupt	169	13	demise	demise	NN
cord-285262-690kpupt	169	14	,	,	,
cord-285262-690kpupt	169	15	which	which	WDT
cord-285262-690kpupt	169	16	consequently	consequently	RB
cord-285262-690kpupt	169	17	would	would	MD
cord-285262-690kpupt	169	18	eliminate	eliminate	VB
cord-285262-690kpupt	169	19	the	the	DT
cord-285262-690kpupt	169	20	essential	essential	JJ
cord-285262-690kpupt	169	21	environment	environment	NN
cord-285262-690kpupt	169	22	of	of	IN
cord-285262-690kpupt	169	23	the	the	DT
cord-285262-690kpupt	169	24	virus	virus	NN
cord-285262-690kpupt	169	25	replication	replication	NN
cord-285262-690kpupt	169	26	.	.	.
cord-285262-690kpupt	170	1	These	these	DT
cord-285262-690kpupt	170	2	strategies	strategy	NNS
cord-285262-690kpupt	170	3	include	include	VBP
cord-285262-690kpupt	170	4	the	the	DT
cord-285262-690kpupt	170	5	expression	expression	NN
cord-285262-690kpupt	170	6	of	of	IN
cord-285262-690kpupt	170	7	apoptosis	apoptosis	NN
cord-285262-690kpupt	170	8	inhibitor	inhibitor	NN
cord-285262-690kpupt	170	9	proteins	protein	NNS
cord-285262-690kpupt	170	10	.	.	.
cord-285262-690kpupt	171	1	The	the	DT
cord-285262-690kpupt	171	2	majority	majority	NN
cord-285262-690kpupt	171	3	of	of	IN
cord-285262-690kpupt	171	4	the	the	DT
cord-285262-690kpupt	171	5	antiapoptotic	antiapoptotic	JJ
cord-285262-690kpupt	171	6	factors	factor	NNS
cord-285262-690kpupt	171	7	are	be	VBP
cord-285262-690kpupt	171	8	encoded	encode	VBN
cord-285262-690kpupt	171	9	by	by	IN
cord-285262-690kpupt	171	10	large	large	JJ
cord-285262-690kpupt	171	11	DNA	dna	NN
cord-285262-690kpupt	171	12	viruses	virus	NNS
cord-285262-690kpupt	171	13	,	,	,
cord-285262-690kpupt	171	14	which	which	WDT
cord-285262-690kpupt	171	15	generally	generally	RB
cord-285262-690kpupt	171	16	replicate	replicate	VBP
cord-285262-690kpupt	171	17	with	with	IN
cord-285262-690kpupt	171	18	slower	slow	JJR
cord-285262-690kpupt	171	19	kinetics	kinetic	NNS
cord-285262-690kpupt	171	20	than	than	IN
cord-285262-690kpupt	171	21	RNA	RNA	NNP
cord-285262-690kpupt	171	22	viruses	virus	NNS
cord-285262-690kpupt	171	23	.	.	.
cord-285262-690kpupt	172	1	A	a	DT
cord-285262-690kpupt	172	2	broad	broad	JJ
cord-285262-690kpupt	172	3	group	group	NN
cord-285262-690kpupt	172	4	of	of	IN
cord-285262-690kpupt	172	5	inhibitors	inhibitor	NNS
cord-285262-690kpupt	172	6	attack	attack	VBP
cord-285262-690kpupt	172	7	the	the	DT
cord-285262-690kpupt	172	8	extrinsic	extrinsic	JJ
cord-285262-690kpupt	172	9	pathway	pathway	NN
cord-285262-690kpupt	172	10	of	of	IN
cord-285262-690kpupt	172	11	apoptosis	apoptosis	NN
cord-285262-690kpupt	172	12	,	,	,
cord-285262-690kpupt	172	13	which	which	WDT
cord-285262-690kpupt	172	14	is	be	VBZ
cord-285262-690kpupt	172	15	triggered	trigger	VBN
cord-285262-690kpupt	172	16	by	by	IN
cord-285262-690kpupt	172	17	an	an	DT
cord-285262-690kpupt	172	18	anti	anti	JJ
cord-285262-690kpupt	172	19	-	-	JJ
cord-285262-690kpupt	172	20	viral	viral	JJ
cord-285262-690kpupt	172	21	immune	immune	JJ
cord-285262-690kpupt	172	22	response	response	NN
cord-285262-690kpupt	172	23	.	.	.
cord-285262-690kpupt	173	1	Viral	Viral	NNP
cord-285262-690kpupt	173	2	FLICE	FLICE	NNP
cord-285262-690kpupt	173	3	-	-	HYPH
cord-285262-690kpupt	173	4	like	like	JJ
cord-285262-690kpupt	173	5	inhibitory	inhibitory	JJ
cord-285262-690kpupt	173	6	protein	protein	NN
cord-285262-690kpupt	173	7	(	(	-LRB-
cord-285262-690kpupt	173	8	vFLIP	vFLIP	NNP
cord-285262-690kpupt	173	9	)	)	-RRB-
cord-285262-690kpupt	173	10	is	be	VBZ
cord-285262-690kpupt	173	11	encoded	encode	VBN
cord-285262-690kpupt	173	12	by	by	IN
cord-285262-690kpupt	173	13	the	the	DT
cord-285262-690kpupt	173	14	Molluscum	Molluscum	NNP
cord-285262-690kpupt	173	15	contagiosum	contagiosum	NN
cord-285262-690kpupt	173	16	virus	virus	NN
cord-285262-690kpupt	173	17	and	and	CC
cord-285262-690kpupt	173	18	several	several	JJ
cord-285262-690kpupt	173	19	gamma	gamma	NN
cord-285262-690kpupt	173	20	Herpes	Herpes	NNP
cord-285262-690kpupt	173	21	viruses	virus	NNS
cord-285262-690kpupt	173	22	,	,	,
cord-285262-690kpupt	173	23	including	include	VBG
cord-285262-690kpupt	173	24	Kaposi	Kaposi	NNP
cord-285262-690kpupt	173	25	's	's	POS
cord-285262-690kpupt	173	26	sarcoma	sarcoma	NN
cord-285262-690kpupt	173	27	-	-	HYPH
cord-285262-690kpupt	173	28	associated	associate	VBN
cord-285262-690kpupt	173	29	herpes	herpes	NN
cord-285262-690kpupt	173	30	virus	virus	NN
cord-285262-690kpupt	173	31	(	(	-LRB-
cord-285262-690kpupt	173	32	KSHV	KSHV	NNP
cord-285262-690kpupt	173	33	)	)	-RRB-
cord-285262-690kpupt	173	34	.	.	.
cord-285262-690kpupt	174	1	The	the	DT
cord-285262-690kpupt	174	2	vFLIP	vFLIP	NNP
cord-285262-690kpupt	174	3	exerts	exert	VBZ
cord-285262-690kpupt	174	4	its	-PRON-	PRP$
cord-285262-690kpupt	174	5	inhibitory	inhibitory	JJ
cord-285262-690kpupt	174	6	activity	activity	NN
cord-285262-690kpupt	174	7	by	by	IN
cord-285262-690kpupt	174	8	binding	bind	VBG
cord-285262-690kpupt	174	9	the	the	DT
cord-285262-690kpupt	174	10	adaptor	adaptor	NN
cord-285262-690kpupt	174	11	protein	protein	NN
cord-285262-690kpupt	174	12	FADD	FADD	NNP
cord-285262-690kpupt	174	13	and	and	CC
cord-285262-690kpupt	174	14	forming	form	VBG
cord-285262-690kpupt	174	15	inactive	inactive	JJ
cord-285262-690kpupt	174	16	caspase-8	caspase-8	NNP
cord-285262-690kpupt	174	17	/	/	SYM
cord-285262-690kpupt	174	18	vFLIP	vFLIP	NNP
cord-285262-690kpupt	174	19	heterodimers	heterodimer	NNS
cord-285262-690kpupt	175	1	(	(	-LRB-
cord-285262-690kpupt	175	2	Thome	Thome	NNP
cord-285262-690kpupt	175	3	et	et	NNP
cord-285262-690kpupt	175	4	al	al	NNP
cord-285262-690kpupt	175	5	.	.	NNP
cord-285262-690kpupt	175	6	,	,	,
cord-285262-690kpupt	175	7	1997	1997	CD
cord-285262-690kpupt	175	8	)	)	-RRB-
cord-285262-690kpupt	175	9	.	.	.
cord-285262-690kpupt	176	1	Human	human	JJ
cord-285262-690kpupt	176	2	cytomegalovirus	cytomegalovirus	NN
cord-285262-690kpupt	176	3	(	(	-LRB-
cord-285262-690kpupt	176	4	CMV	CMV	NNP
cord-285262-690kpupt	176	5	)	)	-RRB-
cord-285262-690kpupt	176	6	is	be	VBZ
cord-285262-690kpupt	176	7	a	a	DT
cord-285262-690kpupt	176	8	common	common	JJ
cord-285262-690kpupt	176	9	infection	infection	NN
cord-285262-690kpupt	176	10	in	in	IN
cord-285262-690kpupt	176	11	humans	human	NNS
cord-285262-690kpupt	176	12	,	,	,
cord-285262-690kpupt	176	13	which	which	WDT
cord-285262-690kpupt	176	14	does	do	VBZ
cord-285262-690kpupt	176	15	not	not	RB
cord-285262-690kpupt	176	16	lead	lead	VB
cord-285262-690kpupt	176	17	to	to	IN
cord-285262-690kpupt	176	18	disease	disease	NN
cord-285262-690kpupt	176	19	in	in	IN
cord-285262-690kpupt	176	20	healthy	healthy	JJ
cord-285262-690kpupt	176	21	individuals	individual	NNS
cord-285262-690kpupt	176	22	,	,	,
cord-285262-690kpupt	176	23	whereas	whereas	IN
cord-285262-690kpupt	176	24	it	-PRON-	PRP
cord-285262-690kpupt	176	25	causes	cause	VBZ
cord-285262-690kpupt	176	26	severe	severe	JJ
cord-285262-690kpupt	176	27	infections	infection	NNS
cord-285262-690kpupt	176	28	or	or	CC
cord-285262-690kpupt	176	29	death	death	NN
cord-285262-690kpupt	176	30	in	in	IN
cord-285262-690kpupt	176	31	patients	patient	NNS
cord-285262-690kpupt	176	32	with	with	IN
cord-285262-690kpupt	176	33	immunodeficiencies	immunodeficiency	NNS
cord-285262-690kpupt	176	34	.	.	.
cord-285262-690kpupt	177	1	The	the	DT
cord-285262-690kpupt	177	2	mouse	mouse	NN
cord-285262-690kpupt	177	3	CMV	CMV	NNP
cord-285262-690kpupt	177	4	(	(	-LRB-
cord-285262-690kpupt	177	5	MCMCV	MCMCV	NNP
cord-285262-690kpupt	177	6	)	)	-RRB-
cord-285262-690kpupt	177	7	is	be	VBZ
cord-285262-690kpupt	177	8	the	the	DT
cord-285262-690kpupt	177	9	experimental	experimental	JJ
cord-285262-690kpupt	177	10	model	model	NN
cord-285262-690kpupt	177	11	of	of	IN
cord-285262-690kpupt	177	12	human	human	JJ
cord-285262-690kpupt	177	13	CMV	CMV	NNP
cord-285262-690kpupt	177	14	infection	infection	NN
cord-285262-690kpupt	177	15	.	.	.
cord-285262-690kpupt	178	1	The	the	DT
cord-285262-690kpupt	178	2	M36	M36	NNP
cord-285262-690kpupt	178	3	protein	protein	NN
cord-285262-690kpupt	178	4	of	of	IN
cord-285262-690kpupt	178	5	the	the	DT
cord-285262-690kpupt	178	6	virus	virus	NN
cord-285262-690kpupt	178	7	blocks	block	NNS
cord-285262-690kpupt	178	8	caspase-8	caspase-8	RB
cord-285262-690kpupt	178	9	driven	drive	VBN
cord-285262-690kpupt	178	10	apoptosis	apoptosis	NN
cord-285262-690kpupt	178	11	and	and	CC
cord-285262-690kpupt	178	12	thus	thus	RB
cord-285262-690kpupt	178	13	contributing	contribute	VBG
cord-285262-690kpupt	178	14	to	to	IN
cord-285262-690kpupt	178	15	the	the	DT
cord-285262-690kpupt	178	16	pathogenicity	pathogenicity	NN
cord-285262-690kpupt	178	17	of	of	IN
cord-285262-690kpupt	178	18	the	the	DT
cord-285262-690kpupt	178	19	microbe	microbe	NN
cord-285262-690kpupt	178	20	(	(	-LRB-
cord-285262-690kpupt	178	21	Ebermann	Ebermann	NNP
cord-285262-690kpupt	178	22	et	et	FW
cord-285262-690kpupt	178	23	al	al	NNP
cord-285262-690kpupt	178	24	.	.	NNP
cord-285262-690kpupt	178	25	,	,	,
cord-285262-690kpupt	178	26	2012	2012	CD
cord-285262-690kpupt	178	27	;	;	:
cord-285262-690kpupt	178	28	Skaletskaya	Skaletskaya	NNP
cord-285262-690kpupt	178	29	et	et	NNP
cord-285262-690kpupt	178	30	al	al	NNP
cord-285262-690kpupt	178	31	.	.	NNP
cord-285262-690kpupt	178	32	,	,	,
cord-285262-690kpupt	178	33	2001	2001	CD
cord-285262-690kpupt	178	34	)	)	-RRB-
cord-285262-690kpupt	178	35	.	.	.
cord-285262-690kpupt	179	1	The	the	DT
cord-285262-690kpupt	179	2	large	large	JJ
cord-285262-690kpupt	179	3	subunit	subunit	NN
cord-285262-690kpupt	179	4	of	of	IN
cord-285262-690kpupt	179	5	the	the	DT
cord-285262-690kpupt	179	6	herpes	herpes	NNP
cord-285262-690kpupt	179	7	simplex	simplex	NNP
cord-285262-690kpupt	179	8	virus	virus	NN
cord-285262-690kpupt	179	9	(	(	-LRB-
cord-285262-690kpupt	179	10	HSV	HSV	NNP
cord-285262-690kpupt	179	11	)	)	-RRB-
cord-285262-690kpupt	179	12	ribonucleotide	ribonucleotide	NN
cord-285262-690kpupt	179	13	reductase	reductase	NN
cord-285262-690kpupt	179	14	ICP10	ICP10	NNP
cord-285262-690kpupt	179	15	demonstrates	demonstrate	VBZ
cord-285262-690kpupt	179	16	caspase-8	caspase-8	NNP
cord-285262-690kpupt	179	17	inhibitory	inhibitory	JJ
cord-285262-690kpupt	179	18	potential	potential	NN
cord-285262-690kpupt	179	19	by	by	IN
cord-285262-690kpupt	179	20	directly	directly	RB
cord-285262-690kpupt	179	21	interacting	interact	VBG
cord-285262-690kpupt	179	22	with	with	IN
cord-285262-690kpupt	179	23	the	the	DT
cord-285262-690kpupt	179	24	initiator	initiator	NN
cord-285262-690kpupt	179	25	caspase	caspase	NN
cord-285262-690kpupt	179	26	(	(	-LRB-
cord-285262-690kpupt	179	27	Dufour	Dufour	NNP
cord-285262-690kpupt	179	28	et	et	NNP
cord-285262-690kpupt	179	29	al	al	NNP
cord-285262-690kpupt	179	30	.	.	NNP
cord-285262-690kpupt	179	31	,	,	,
cord-285262-690kpupt	179	32	2011	2011	CD
cord-285262-690kpupt	179	33	;	;	:
cord-285262-690kpupt	179	34	Langelier	Langelier	NNP
cord-285262-690kpupt	179	35	et	et	NNP
cord-285262-690kpupt	179	36	al	al	NNP
cord-285262-690kpupt	179	37	.	.	NNP
cord-285262-690kpupt	179	38	,	,	,
cord-285262-690kpupt	179	39	2002	2002	CD
cord-285262-690kpupt	179	40	)	)	-RRB-
cord-285262-690kpupt	179	41	.	.	.
cord-285262-690kpupt	180	1	The	the	DT
cord-285262-690kpupt	180	2	cytokine	cytokine	NN
cord-285262-690kpupt	180	3	response	response	NN
cord-285262-690kpupt	180	4	modifier	modifier	NN
cord-285262-690kpupt	180	5	A	a	NN
cord-285262-690kpupt	180	6	(	(	-LRB-
cord-285262-690kpupt	180	7	CrmA	CrmA	NNP
cord-285262-690kpupt	180	8	)	)	-RRB-
cord-285262-690kpupt	180	9	,	,	,
cord-285262-690kpupt	180	10	a	a	DT
cord-285262-690kpupt	180	11	product	product	NN
cord-285262-690kpupt	180	12	of	of	IN
cord-285262-690kpupt	180	13	the	the	DT
cord-285262-690kpupt	180	14	Cowpox	Cowpox	NNP
cord-285262-690kpupt	180	15	virus	virus	NN
cord-285262-690kpupt	180	16	,	,	,
cord-285262-690kpupt	180	17	prevents	prevent	VBZ
cord-285262-690kpupt	180	18	apoptosis	apoptosis	NN
cord-285262-690kpupt	180	19	by	by	IN
cord-285262-690kpupt	180	20	blocking	block	VBG
cord-285262-690kpupt	180	21	the	the	DT
cord-285262-690kpupt	180	22	activity	activity	NN
cord-285262-690kpupt	180	23	of	of	IN
cord-285262-690kpupt	180	24	caspase-8	caspase-8	NNP
cord-285262-690kpupt	180	25	(	(	-LRB-
cord-285262-690kpupt	180	26	Zhou	Zhou	NNP
cord-285262-690kpupt	180	27	et	et	NNP
cord-285262-690kpupt	180	28	al	al	NNP
cord-285262-690kpupt	180	29	.	.	NNP
cord-285262-690kpupt	180	30	,	,	,
cord-285262-690kpupt	180	31	1997	1997	CD
cord-285262-690kpupt	180	32	)	)	-RRB-
cord-285262-690kpupt	180	33	.	.	.
cord-285262-690kpupt	181	1	Other	other	JJ
cord-285262-690kpupt	181	2	group	group	NN
cord-285262-690kpupt	181	3	of	of	IN
cord-285262-690kpupt	181	4	viral	viral	JJ
cord-285262-690kpupt	181	5	anti	anti	JJ
cord-285262-690kpupt	181	6	-	-	JJ
cord-285262-690kpupt	181	7	apoptotic	apoptotic	JJ
cord-285262-690kpupt	181	8	proteins	protein	NNS
cord-285262-690kpupt	181	9	modulates	modulate	VBZ
cord-285262-690kpupt	181	10	the	the	DT
cord-285262-690kpupt	181	11	expression	expression	NN
cord-285262-690kpupt	181	12	of	of	IN
cord-285262-690kpupt	181	13	cellular	cellular	JJ
cord-285262-690kpupt	181	14	anti	anti	JJ
cord-285262-690kpupt	181	15	-	-	JJ
cord-285262-690kpupt	181	16	apoptotic	apoptotic	JJ
cord-285262-690kpupt	181	17	proteins	protein	NNS
cord-285262-690kpupt	181	18	.	.	.
cord-285262-690kpupt	182	1	The	the	DT
cord-285262-690kpupt	182	2	human	human	JJ
cord-285262-690kpupt	182	3	T	t	NN
cord-285262-690kpupt	182	4	-	-	HYPH
cord-285262-690kpupt	182	5	cell	cell	NN
cord-285262-690kpupt	182	6	leukemia	leukemia	NN
cord-285262-690kpupt	182	7	virus	virus	NN
cord-285262-690kpupt	182	8	type-1	type-1	NN
cord-285262-690kpupt	182	9	(	(	-LRB-
cord-285262-690kpupt	182	10	HTLV-1)-associated	htlv-1)-associate	VBN
cord-285262-690kpupt	182	11	adult	adult	NN
cord-285262-690kpupt	182	12	T	t	NN
cord-285262-690kpupt	182	13	-	-	HYPH
cord-285262-690kpupt	182	14	cell	cell	NN
cord-285262-690kpupt	182	15	leukemia	leukemia	NN
cord-285262-690kpupt	182	16	/	/	SYM
cord-285262-690kpupt	182	17	lymphoma	lymphoma	NN
cord-285262-690kpupt	182	18	(	(	-LRB-
cord-285262-690kpupt	182	19	ATL	ATL	NNP
cord-285262-690kpupt	182	20	)	)	-RRB-
cord-285262-690kpupt	182	21	is	be	VBZ
cord-285262-690kpupt	182	22	a	a	DT
cord-285262-690kpupt	182	23	malignancy	malignancy	NN
cord-285262-690kpupt	182	24	of	of	IN
cord-285262-690kpupt	182	25	infected	infected	JJ
cord-285262-690kpupt	182	26	mature	mature	JJ
cord-285262-690kpupt	182	27	CD4	CD4	NNP
cord-285262-690kpupt	182	28	T	T	NNP
cord-285262-690kpupt	182	29	cells	cell	NNS
cord-285262-690kpupt	182	30	in	in	IN
cord-285262-690kpupt	182	31	humans	human	NNS
cord-285262-690kpupt	182	32	(	(	-LRB-
cord-285262-690kpupt	182	33	Matsuoka	Matsuoka	NNP
cord-285262-690kpupt	182	34	and	and	CC
cord-285262-690kpupt	182	35	Jeang	Jeang	NNP
cord-285262-690kpupt	182	36	,	,	,
cord-285262-690kpupt	182	37	2007	2007	CD
cord-285262-690kpupt	182	38	)	)	-RRB-
cord-285262-690kpupt	182	39	.	.	.
cord-285262-690kpupt	183	1	The	the	DT
cord-285262-690kpupt	183	2	transactivator	transactivator	NN
cord-285262-690kpupt	183	3	protein	protein	NN
cord-285262-690kpupt	183	4	TAX	tax	NN
cord-285262-690kpupt	183	5	of	of	IN
cord-285262-690kpupt	183	6	HTLV-1	HTLV-1	NNP
cord-285262-690kpupt	183	7	upregulates	upregulate	VBZ
cord-285262-690kpupt	183	8	the	the	DT
cord-285262-690kpupt	183	9	expression	expression	NN
cord-285262-690kpupt	183	10	of	of	IN
cord-285262-690kpupt	183	11	cFLIP	cFLIP	NNP
cord-285262-690kpupt	183	12	by	by	IN
cord-285262-690kpupt	183	13	binding	bind	VBG
cord-285262-690kpupt	183	14	to	to	IN
cord-285262-690kpupt	183	15	the	the	DT
cord-285262-690kpupt	183	16	inhibitor	inhibitor	NN
cord-285262-690kpupt	183	17	of	of	IN
cord-285262-690kpupt	183	18	κB	κb	CD
cord-285262-690kpupt	183	19	kinase	kinase	NNS
cord-285262-690kpupt	183	20	(	(	-LRB-
cord-285262-690kpupt	183	21	IKK	IKK	NNP
cord-285262-690kpupt	183	22	)	)	-RRB-
cord-285262-690kpupt	183	23	and	and	CC
cord-285262-690kpupt	183	24	inducing	induce	VBG
cord-285262-690kpupt	183	25	the	the	DT
cord-285262-690kpupt	183	26	NF	nf	NN
cord-285262-690kpupt	183	27	-	-	HYPH
cord-285262-690kpupt	183	28	κB	κB	NNP
cord-285262-690kpupt	183	29	pathway	pathway	NN
cord-285262-690kpupt	183	30	in	in	IN
cord-285262-690kpupt	183	31	the	the	DT
cord-285262-690kpupt	183	32	host	host	NN
cord-285262-690kpupt	183	33	cells	cell	NNS
cord-285262-690kpupt	183	34	,	,	,
cord-285262-690kpupt	183	35	and	and	CC
cord-285262-690kpupt	183	36	thereby	thereby	RB
cord-285262-690kpupt	183	37	the	the	DT
cord-285262-690kpupt	183	38	virus	virus	NN
cord-285262-690kpupt	183	39	efficiently	efficiently	RB
cord-285262-690kpupt	183	40	amplifies	amplify	VBZ
cord-285262-690kpupt	183	41	the	the	DT
cord-285262-690kpupt	183	42	apoptosis	apoptosis	NN
cord-285262-690kpupt	183	43	resistance	resistance	NN
cord-285262-690kpupt	183	44	in	in	IN
cord-285262-690kpupt	183	45	infected	infected	JJ
cord-285262-690kpupt	183	46	cells	cell	NNS
cord-285262-690kpupt	183	47	(	(	-LRB-
cord-285262-690kpupt	183	48	Okamoto	Okamoto	NNP
cord-285262-690kpupt	183	49	et	et	NNP
cord-285262-690kpupt	183	50	al	al	NNP
cord-285262-690kpupt	183	51	.	.	NNP
cord-285262-690kpupt	183	52	,	,	,
cord-285262-690kpupt	183	53	2006	2006	CD
cord-285262-690kpupt	183	54	)	)	-RRB-
cord-285262-690kpupt	183	55	.	.	.
cord-285262-690kpupt	184	1	A	a	DT
cord-285262-690kpupt	184	2	further	further	JJ
cord-285262-690kpupt	184	3	group	group	NN
cord-285262-690kpupt	184	4	of	of	IN
cord-285262-690kpupt	184	5	virally	virally	RB
cord-285262-690kpupt	184	6	encoded	encode	VBN
cord-285262-690kpupt	184	7	anti	anti	JJ
cord-285262-690kpupt	184	8	-	-	JJ
cord-285262-690kpupt	184	9	apoptotic	apoptotic	JJ
cord-285262-690kpupt	184	10	factors	factor	NNS
cord-285262-690kpupt	184	11	target	target	VBP
cord-285262-690kpupt	184	12	the	the	DT
cord-285262-690kpupt	184	13	intrinsic	intrinsic	JJ
cord-285262-690kpupt	184	14	apoptosis	apoptosis	NN
cord-285262-690kpupt	184	15	signaling	signal	VBG
cord-285262-690kpupt	184	16	.	.	.
cord-285262-690kpupt	185	1	The	the	DT
cord-285262-690kpupt	185	2	Vaccinia	Vaccinia	NNP
cord-285262-690kpupt	185	3	virus	virus	NN
cord-285262-690kpupt	185	4	encoded	encode	VBD
cord-285262-690kpupt	185	5	F1L	f1l	JJ
cord-285262-690kpupt	185	6	protein	protein	NN
cord-285262-690kpupt	185	7	inhibits	inhibit	VBZ
cord-285262-690kpupt	185	8	the	the	DT
cord-285262-690kpupt	185	9	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	185	10	apoptotic	apoptotic	JJ
cord-285262-690kpupt	185	11	signaling	signaling	NN
cord-285262-690kpupt	185	12	in	in	IN
cord-285262-690kpupt	185	13	two	two	CD
cord-285262-690kpupt	185	14	distinct	distinct	JJ
cord-285262-690kpupt	185	15	ways	way	NNS
cord-285262-690kpupt	185	16	.	.	.
cord-285262-690kpupt	186	1	F1L	F1L	NNP
cord-285262-690kpupt	186	2	functions	function	NNS
cord-285262-690kpupt	186	3	both	both	DT
cord-285262-690kpupt	186	4	as	as	IN
cord-285262-690kpupt	186	5	an	an	DT
cord-285262-690kpupt	186	6	inhibitor	inhibitor	NN
cord-285262-690kpupt	186	7	of	of	IN
cord-285262-690kpupt	186	8	pro	pro	JJ
cord-285262-690kpupt	186	9	-	-	JJ
cord-285262-690kpupt	186	10	apoptotic	apoptotic	JJ
cord-285262-690kpupt	186	11	BCL-2	BCL-2	NNP
cord-285262-690kpupt	186	12	family	family	NN
cord-285262-690kpupt	186	13	proteins	protein	NNS
cord-285262-690kpupt	186	14	and	and	CC
cord-285262-690kpupt	186	15	as	as	IN
cord-285262-690kpupt	186	16	a	a	DT
cord-285262-690kpupt	186	17	direct	direct	JJ
cord-285262-690kpupt	186	18	caspase-9	caspase-9	NNP
cord-285262-690kpupt	186	19	inhibitor	inhibitor	NN
cord-285262-690kpupt	186	20	(	(	-LRB-
cord-285262-690kpupt	186	21	Zhai	Zhai	NNP
cord-285262-690kpupt	186	22	et	et	NNP
cord-285262-690kpupt	186	23	al	al	NNP
cord-285262-690kpupt	186	24	.	.	NNP
cord-285262-690kpupt	186	25	,	,	,
cord-285262-690kpupt	186	26	2010	2010	CD
cord-285262-690kpupt	186	27	)	)	-RRB-
cord-285262-690kpupt	186	28	.	.	.
cord-285262-690kpupt	187	1	Human	human	JJ
cord-285262-690kpupt	187	2	papillomavirus	papillomavirus	NN
cord-285262-690kpupt	187	3	(	(	-LRB-
cord-285262-690kpupt	187	4	HPV	HPV	NNP
cord-285262-690kpupt	187	5	)	)	-RRB-
cord-285262-690kpupt	187	6	,	,	,
cord-285262-690kpupt	187	7	a	a	DT
cord-285262-690kpupt	187	8	double	double	RB
cord-285262-690kpupt	187	9	-	-	HYPH
cord-285262-690kpupt	187	10	stranded	stranded	JJ
cord-285262-690kpupt	187	11	DNA	dna	NN
cord-285262-690kpupt	187	12	virus	virus	NN
cord-285262-690kpupt	187	13	has	have	VBZ
cord-285262-690kpupt	187	14	been	be	VBN
cord-285262-690kpupt	187	15	associated	associate	VBN
cord-285262-690kpupt	187	16	with	with	IN
cord-285262-690kpupt	187	17	cervical	cervical	JJ
cord-285262-690kpupt	187	18	cancer	cancer	NN
cord-285262-690kpupt	187	19	developments	development	NNS
cord-285262-690kpupt	187	20	in	in	IN
cord-285262-690kpupt	187	21	humans	human	NNS
cord-285262-690kpupt	187	22	(	(	-LRB-
cord-285262-690kpupt	187	23	D€	D€	NNP
cord-285262-690kpupt	187	24	urst	urst	NN
cord-285262-690kpupt	188	1	et	et	NNP
cord-285262-690kpupt	188	2	al	al	NNP
cord-285262-690kpupt	188	3	.	.	NNP
cord-285262-690kpupt	188	4	,	,	,
cord-285262-690kpupt	188	5	1983	1983	CD
cord-285262-690kpupt	188	6	)	)	-RRB-
cord-285262-690kpupt	188	7	.	.	.
cord-285262-690kpupt	189	1	The	the	DT
cord-285262-690kpupt	189	2	early	early	JJ
cord-285262-690kpupt	189	3	gene	gene	NN
cord-285262-690kpupt	189	4	-	-	HYPH
cord-285262-690kpupt	189	5	coding	code	VBG
cord-285262-690kpupt	189	6	region	region	NN
cord-285262-690kpupt	189	7	protein	protein	NN
cord-285262-690kpupt	189	8	6	6	CD
cord-285262-690kpupt	189	9	(	(	-LRB-
cord-285262-690kpupt	189	10	E6	E6	NNP
cord-285262-690kpupt	189	11	)	)	-RRB-
cord-285262-690kpupt	189	12	of	of	IN
cord-285262-690kpupt	189	13	HPV	HPV	NNP
cord-285262-690kpupt	189	14	is	be	VBZ
cord-285262-690kpupt	189	15	reported	report	VBN
cord-285262-690kpupt	189	16	to	to	TO
cord-285262-690kpupt	189	17	interfere	interfere	VB
cord-285262-690kpupt	189	18	with	with	IN
cord-285262-690kpupt	189	19	apoptosis	apoptosis	NN
cord-285262-690kpupt	189	20	signaling	signal	VBG
cord-285262-690kpupt	189	21	at	at	IN
cord-285262-690kpupt	189	22	the	the	DT
cord-285262-690kpupt	189	23	level	level	NN
cord-285262-690kpupt	189	24	of	of	IN
cord-285262-690kpupt	189	25	p53	p53	NN
cord-285262-690kpupt	189	26	and	and	CC
cord-285262-690kpupt	189	27	by	by	IN
cord-285262-690kpupt	189	28	interacting	interact	VBG
cord-285262-690kpupt	189	29	with	with	IN
cord-285262-690kpupt	189	30	the	the	DT
cord-285262-690kpupt	189	31	pro	pro	JJ
cord-285262-690kpupt	189	32	-	-	JJ
cord-285262-690kpupt	189	33	apoptotic	apoptotic	JJ
cord-285262-690kpupt	189	34	BAK	BAK	NNP
cord-285262-690kpupt	189	35	protein	protein	NN
cord-285262-690kpupt	189	36	.	.	.
cord-285262-690kpupt	190	1	In	in	IN
cord-285262-690kpupt	190	2	contrast	contrast	NN
cord-285262-690kpupt	190	3	to	to	IN
cord-285262-690kpupt	190	4	viruses	virus	NNS
cord-285262-690kpupt	190	5	,	,	,
cord-285262-690kpupt	190	6	bacteria	bacteria	NNS
cord-285262-690kpupt	190	7	are	be	VBP
cord-285262-690kpupt	190	8	not	not	RB
cord-285262-690kpupt	190	9	essentially	essentially	RB
cord-285262-690kpupt	190	10	dependent	dependent	JJ
cord-285262-690kpupt	190	11	on	on	IN
cord-285262-690kpupt	190	12	the	the	DT
cord-285262-690kpupt	190	13	intracellular	intracellular	JJ
cord-285262-690kpupt	190	14	environment	environment	NN
cord-285262-690kpupt	190	15	.	.	.
cord-285262-690kpupt	191	1	Moreover	moreover	RB
cord-285262-690kpupt	191	2	,	,	,
cord-285262-690kpupt	191	3	intact	intact	JJ
cord-285262-690kpupt	191	4	cellular	cellular	JJ
cord-285262-690kpupt	191	5	layers	layer	NNS
cord-285262-690kpupt	191	6	exhibit	exhibit	VBP
cord-285262-690kpupt	191	7	physical	physical	JJ
cord-285262-690kpupt	191	8	barriers	barrier	NNS
cord-285262-690kpupt	191	9	against	against	IN
cord-285262-690kpupt	191	10	bacterial	bacterial	JJ
cord-285262-690kpupt	191	11	penetration	penetration	NN
cord-285262-690kpupt	191	12	.	.	.
cord-285262-690kpupt	192	1	Therefore	therefore	RB
cord-285262-690kpupt	192	2	,	,	,
cord-285262-690kpupt	192	3	extracellular	extracellular	JJ
cord-285262-690kpupt	192	4	bacteria	bacteria	NNS
cord-285262-690kpupt	192	5	developed	develop	VBD
cord-285262-690kpupt	192	6	strategies	strategy	NNS
cord-285262-690kpupt	192	7	to	to	TO
cord-285262-690kpupt	192	8	efficiently	efficiently	RB
cord-285262-690kpupt	192	9	destroy	destroy	VB
cord-285262-690kpupt	192	10	these	these	DT
cord-285262-690kpupt	192	11	barrier	barrier	NN
cord-285262-690kpupt	192	12	functions	function	NNS
cord-285262-690kpupt	192	13	.	.	.
cord-285262-690kpupt	193	1	A	a	DT
cord-285262-690kpupt	193	2	novel	novel	JJ
cord-285262-690kpupt	193	3	study	study	NN
cord-285262-690kpupt	193	4	presents	present	VBZ
cord-285262-690kpupt	193	5	the	the	DT
cord-285262-690kpupt	193	6	bacterial	bacterial	JJ
cord-285262-690kpupt	193	7	qourum	qourum	NN
cord-285262-690kpupt	193	8	-	-	HYPH
cord-285262-690kpupt	193	9	sensing	sense	VBG
cord-285262-690kpupt	193	10	autoinducer	autoinducer	NN
cord-285262-690kpupt	193	11	of	of	IN
cord-285262-690kpupt	193	12	the	the	DT
cord-285262-690kpupt	193	13	Pseudomonas	Pseudomonas	NNP
cord-285262-690kpupt	193	14	aeruginosa	aeruginosa	VBZ
cord-285262-690kpupt	193	15	N-(3-oxo	N-(3-oxo	NNP
cord-285262-690kpupt	193	16	-	-	HYPH
cord-285262-690kpupt	193	17	dodecanoyl	dodecanoyl	NNP
cord-285262-690kpupt	193	18	)	)	-RRB-
cord-285262-690kpupt	193	19	homoserine	homoserine	NNP
cord-285262-690kpupt	193	20	lactone	lactone	NNP
cord-285262-690kpupt	193	21	(	(	-LRB-
cord-285262-690kpupt	193	22	3oc	3oc	NNP
cord-285262-690kpupt	193	23	)	)	-RRB-
cord-285262-690kpupt	193	24	,	,	,
cord-285262-690kpupt	193	25	a	a	DT
cord-285262-690kpupt	193	26	small	small	JJ
cord-285262-690kpupt	193	27	chemical	chemical	NN
cord-285262-690kpupt	193	28	released	release	VBN
cord-285262-690kpupt	193	29	to	to	TO
cord-285262-690kpupt	193	30	control	control	VB
cord-285262-690kpupt	193	31	microbial	microbial	JJ
cord-285262-690kpupt	193	32	communication	communication	NN
cord-285262-690kpupt	193	33	,	,	,
cord-285262-690kpupt	193	34	as	as	IN
cord-285262-690kpupt	193	35	an	an	DT
cord-285262-690kpupt	193	36	inducer	inducer	NN
cord-285262-690kpupt	193	37	of	of	IN
cord-285262-690kpupt	193	38	TNFR1	TNFR1	NNP
cord-285262-690kpupt	193	39	.	.	.
cord-285262-690kpupt	194	1	It	-PRON-	PRP
cord-285262-690kpupt	194	2	is	be	VBZ
cord-285262-690kpupt	194	3	demonstrated	demonstrate	VBN
cord-285262-690kpupt	194	4	that	that	IN
cord-285262-690kpupt	194	5	3oc	3oc	NN
cord-285262-690kpupt	194	6	directly	directly	RB
cord-285262-690kpupt	194	7	disrupts	disrupt	VBZ
cord-285262-690kpupt	194	8	the	the	DT
cord-285262-690kpupt	194	9	lipid	lipid	NN
cord-285262-690kpupt	194	10	domain	domain	NN
cord-285262-690kpupt	194	11	structures	structure	NNS
cord-285262-690kpupt	194	12	,	,	,
cord-285262-690kpupt	194	13	containing	contain	VBG
cord-285262-690kpupt	194	14	sphingolipids	sphingolipid	NNS
cord-285262-690kpupt	194	15	and	and	CC
cord-285262-690kpupt	194	16	cholesterol	cholesterol	NN
cord-285262-690kpupt	194	17	,	,	,
cord-285262-690kpupt	194	18	and	and	CC
cord-285262-690kpupt	194	19	induces	induce	VBZ
cord-285262-690kpupt	194	20	the	the	DT
cord-285262-690kpupt	194	21	translocation	translocation	NN
cord-285262-690kpupt	194	22	of	of	IN
cord-285262-690kpupt	194	23	TNFR1	tnfr1	XX
cord-285262-690kpupt	194	24	into	into	IN
cord-285262-690kpupt	194	25	the	the	DT
cord-285262-690kpupt	194	26	disordered	disordered	JJ
cord-285262-690kpupt	194	27	lipid	lipid	NN
cord-285262-690kpupt	194	28	phase	phase	NN
cord-285262-690kpupt	194	29	of	of	IN
cord-285262-690kpupt	194	30	the	the	DT
cord-285262-690kpupt	194	31	membrane	membrane	NN
cord-285262-690kpupt	194	32	,	,	,
cord-285262-690kpupt	194	33	which	which	WDT
cord-285262-690kpupt	194	34	in	in	IN
cord-285262-690kpupt	194	35	turn	turn	NN
cord-285262-690kpupt	194	36	triggers	trigger	VBZ
cord-285262-690kpupt	194	37	the	the	DT
cord-285262-690kpupt	194	38	trimerization	trimerization	NN
cord-285262-690kpupt	194	39	of	of	IN
cord-285262-690kpupt	194	40	the	the	DT
cord-285262-690kpupt	194	41	TNFR	TNFR	NNP
cord-285262-690kpupt	194	42	and	and	CC
cord-285262-690kpupt	194	43	leads	lead	VBZ
cord-285262-690kpupt	194	44	to	to	IN
cord-285262-690kpupt	194	45	subsequent	subsequent	JJ
cord-285262-690kpupt	194	46	apoptosis	apoptosis	NN
cord-285262-690kpupt	194	47	in	in	IN
cord-285262-690kpupt	194	48	human	human	NN
cord-285262-690kpupt	194	49	and	and	CC
cord-285262-690kpupt	194	50	mice	mice	NN
cord-285262-690kpupt	194	51	monocytes	monocyte	NNS
cord-285262-690kpupt	194	52	(	(	-LRB-
cord-285262-690kpupt	194	53	Song	Song	NNP
cord-285262-690kpupt	194	54	et	et	FW
cord-285262-690kpupt	194	55	al	al	NNP
cord-285262-690kpupt	194	56	.	.	NNP
cord-285262-690kpupt	194	57	,	,	,
cord-285262-690kpupt	194	58	2019	2019	CD
cord-285262-690kpupt	194	59	)	)	-RRB-
cord-285262-690kpupt	194	60	.	.	.
cord-285262-690kpupt	195	1	This	this	DT
cord-285262-690kpupt	195	2	type	type	NN
cord-285262-690kpupt	195	3	of	of	IN
cord-285262-690kpupt	195	4	TNFR	TNFR	NNP
cord-285262-690kpupt	195	5	activation	activation	NN
cord-285262-690kpupt	195	6	ensures	ensure	VBZ
cord-285262-690kpupt	195	7	a	a	DT
cord-285262-690kpupt	195	8	ligand	ligand	NN
cord-285262-690kpupt	195	9	independent	independent	JJ
cord-285262-690kpupt	195	10	induction	induction	NN
cord-285262-690kpupt	195	11	of	of	IN
cord-285262-690kpupt	195	12	the	the	DT
cord-285262-690kpupt	195	13	extrinsic	extrinsic	JJ
cord-285262-690kpupt	195	14	pathway	pathway	NN
cord-285262-690kpupt	195	15	.	.	.
cord-285262-690kpupt	196	1	Another	another	DT
cord-285262-690kpupt	196	2	type	type	NN
cord-285262-690kpupt	196	3	of	of	IN
cord-285262-690kpupt	196	4	cell	cell	NN
cord-285262-690kpupt	196	5	killing	killing	NN
cord-285262-690kpupt	196	6	involves	involve	VBZ
cord-285262-690kpupt	196	7	neighboring	neighbor	VBG
cord-285262-690kpupt	196	8	immune	immune	JJ
cord-285262-690kpupt	196	9	cells	cell	NNS
cord-285262-690kpupt	196	10	.	.	.
cord-285262-690kpupt	197	1	The	the	DT
cord-285262-690kpupt	197	2	Gram	gram	NN
cord-285262-690kpupt	197	3	-	-	HYPH
cord-285262-690kpupt	197	4	positive	positive	JJ
cord-285262-690kpupt	197	5	bacteria	bacteria	NNS
cord-285262-690kpupt	197	6	Listeria	Listeria	NNP
cord-285262-690kpupt	197	7	monocytogenes	monocytogene	NNS
cord-285262-690kpupt	197	8	conducts	conduct	VBZ
cord-285262-690kpupt	197	9	the	the	DT
cord-285262-690kpupt	197	10	sorting	sorting	NN
cord-285262-690kpupt	197	11	of	of	IN
cord-285262-690kpupt	197	12	the	the	DT
cord-285262-690kpupt	197	13	bacterial	bacterial	JJ
cord-285262-690kpupt	197	14	DNA	dna	NN
cord-285262-690kpupt	197	15	into	into	IN
cord-285262-690kpupt	197	16	extracellular	extracellular	JJ
cord-285262-690kpupt	197	17	vesicles	vesicle	NNS
cord-285262-690kpupt	197	18	,	,	,
cord-285262-690kpupt	197	19	which	which	WDT
cord-285262-690kpupt	197	20	in	in	IN
cord-285262-690kpupt	197	21	turn	turn	NN
cord-285262-690kpupt	197	22	are	be	VBP
cord-285262-690kpupt	197	23	delivered	deliver	VBN
cord-285262-690kpupt	197	24	to	to	IN
cord-285262-690kpupt	197	25	bystander	bystander	NN
cord-285262-690kpupt	197	26	T	t	NN
cord-285262-690kpupt	197	27	cells	cell	NNS
cord-285262-690kpupt	197	28	,	,	,
cord-285262-690kpupt	197	29	where	where	WRB
cord-285262-690kpupt	197	30	they	-PRON-	PRP
cord-285262-690kpupt	197	31	trigger	trigger	VBP
cord-285262-690kpupt	197	32	the	the	DT
cord-285262-690kpupt	197	33	DNA	dna	NN
cord-285262-690kpupt	197	34	sensor	sensor	NN
cord-285262-690kpupt	197	35	cGAS	cgas	NN
cord-285262-690kpupt	197	36	-	-	HYPH
cord-285262-690kpupt	197	37	STING	sting	NN
cord-285262-690kpupt	197	38	pathway	pathway	NN
cord-285262-690kpupt	197	39	mediated	mediate	VBN
cord-285262-690kpupt	197	40	apoptosis	apoptosis	NN
cord-285262-690kpupt	197	41	(	(	-LRB-
cord-285262-690kpupt	197	42	Nandakumar	Nandakumar	NNP
cord-285262-690kpupt	197	43	et	et	NNP
cord-285262-690kpupt	197	44	al	al	NNP
cord-285262-690kpupt	197	45	.	.	NNP
cord-285262-690kpupt	197	46	,	,	,
cord-285262-690kpupt	197	47	2019	2019	CD
cord-285262-690kpupt	197	48	)	)	-RRB-
cord-285262-690kpupt	197	49	.	.	.
cord-285262-690kpupt	198	1	Yersinia	Yersinia	NNP
cord-285262-690kpupt	198	2	pestis	pestis	NN
cord-285262-690kpupt	198	3	,	,	,
cord-285262-690kpupt	198	4	the	the	DT
cord-285262-690kpupt	198	5	causative	causative	JJ
cord-285262-690kpupt	198	6	agent	agent	NN
cord-285262-690kpupt	198	7	of	of	IN
cord-285262-690kpupt	198	8	pest	pest	NN
cord-285262-690kpupt	198	9	,	,	,
cord-285262-690kpupt	198	10	induces	induce	VBZ
cord-285262-690kpupt	198	11	significant	significant	JJ
cord-285262-690kpupt	198	12	cytotoxicity	cytotoxicity	NN
cord-285262-690kpupt	198	13	.	.	.
cord-285262-690kpupt	199	1	The	the	DT
cord-285262-690kpupt	199	2	type	type	NN
cord-285262-690kpupt	199	3	three	three	CD
cord-285262-690kpupt	199	4	secretion	secretion	NN
cord-285262-690kpupt	199	5	system	system	NN
cord-285262-690kpupt	199	6	(	(	-LRB-
cord-285262-690kpupt	199	7	T3SS	t3ss	NN
cord-285262-690kpupt	199	8	)	)	-RRB-
cord-285262-690kpupt	199	9	is	be	VBZ
cord-285262-690kpupt	199	10	a	a	DT
cord-285262-690kpupt	199	11	host	host	NN
cord-285262-690kpupt	199	12	sensor	sensor	NN
cord-285262-690kpupt	199	13	and	and	CC
cord-285262-690kpupt	199	14	effector	effector	NN
cord-285262-690kpupt	199	15	system	system	NN
cord-285262-690kpupt	199	16	,	,	,
cord-285262-690kpupt	199	17	which	which	WDT
cord-285262-690kpupt	199	18	can	can	MD
cord-285262-690kpupt	199	19	be	be	VB
cord-285262-690kpupt	199	20	found	find	VBN
cord-285262-690kpupt	199	21	in	in	IN
cord-285262-690kpupt	199	22	several	several	JJ
cord-285262-690kpupt	199	23	Gram	gram	NN
cord-285262-690kpupt	199	24	-	-	HYPH
cord-285262-690kpupt	199	25	negative	negative	JJ
cord-285262-690kpupt	199	26	bacteria	bacteria	NNS
cord-285262-690kpupt	199	27	.	.	.
cord-285262-690kpupt	200	1	This	this	DT
cord-285262-690kpupt	200	2	system	system	NN
cord-285262-690kpupt	200	3	promotes	promote	VBZ
cord-285262-690kpupt	200	4	the	the	DT
cord-285262-690kpupt	200	5	virulence	virulence	NN
cord-285262-690kpupt	200	6	of	of	IN
cord-285262-690kpupt	200	7	the	the	DT
cord-285262-690kpupt	200	8	bacteria	bacteria	NNS
cord-285262-690kpupt	200	9	by	by	IN
cord-285262-690kpupt	200	10	injecting	inject	VBG
cord-285262-690kpupt	200	11	effector	effector	NN
cord-285262-690kpupt	200	12	proteins	protein	NNS
cord-285262-690kpupt	200	13	into	into	IN
cord-285262-690kpupt	200	14	the	the	DT
cord-285262-690kpupt	200	15	cytosol	cytosol	NN
cord-285262-690kpupt	200	16	(	(	-LRB-
cord-285262-690kpupt	200	17	Ashida	Ashida	NNP
cord-285262-690kpupt	200	18	et	et	NNP
cord-285262-690kpupt	200	19	al	al	NNP
cord-285262-690kpupt	200	20	.	.	NNP
cord-285262-690kpupt	200	21	,	,	,
cord-285262-690kpupt	200	22	2011	2011	CD
cord-285262-690kpupt	200	23	)	)	-RRB-
cord-285262-690kpupt	200	24	.	.	.
cord-285262-690kpupt	201	1	Structurally	structurally	RB
cord-285262-690kpupt	201	2	,	,	,
cord-285262-690kpupt	201	3	TT3S	tt3s	XX
cord-285262-690kpupt	201	4	consists	consist	VBZ
cord-285262-690kpupt	201	5	of	of	IN
cord-285262-690kpupt	201	6	a	a	DT
cord-285262-690kpupt	201	7	base	base	NN
cord-285262-690kpupt	201	8	embedded	embed	VBN
cord-285262-690kpupt	201	9	in	in	IN
cord-285262-690kpupt	201	10	the	the	DT
cord-285262-690kpupt	201	11	bacterial	bacterial	JJ
cord-285262-690kpupt	201	12	membrane	membrane	NN
cord-285262-690kpupt	201	13	,	,	,
cord-285262-690kpupt	201	14	the	the	DT
cord-285262-690kpupt	201	15	needle	needle	NN
cord-285262-690kpupt	201	16	,	,	,
cord-285262-690kpupt	201	17	which	which	WDT
cord-285262-690kpupt	201	18	directly	directly	RB
cord-285262-690kpupt	201	19	interacts	interact	VBZ
cord-285262-690kpupt	201	20	with	with	IN
cord-285262-690kpupt	201	21	the	the	DT
cord-285262-690kpupt	201	22	host	host	NN
cord-285262-690kpupt	201	23	membrane	membrane	NN
cord-285262-690kpupt	201	24	,	,	,
cord-285262-690kpupt	201	25	and	and	CC
cord-285262-690kpupt	201	26	the	the	DT
cord-285262-690kpupt	201	27	rod	rod	NN
cord-285262-690kpupt	201	28	,	,	,
cord-285262-690kpupt	201	29	which	which	WDT
cord-285262-690kpupt	201	30	connects	connect	VBZ
cord-285262-690kpupt	201	31	the	the	DT
cord-285262-690kpupt	201	32	base	base	NN
cord-285262-690kpupt	201	33	to	to	IN
cord-285262-690kpupt	201	34	the	the	DT
cord-285262-690kpupt	201	35	needle	needle	NN
cord-285262-690kpupt	201	36	.	.	.
cord-285262-690kpupt	202	1	Yersinia	Yersinia	NNP
cord-285262-690kpupt	202	2	outer	outer	JJ
cord-285262-690kpupt	202	3	protein	protein	NN
cord-285262-690kpupt	202	4	J	J	NNP
cord-285262-690kpupt	202	5	(	(	-LRB-
cord-285262-690kpupt	202	6	YopJ	YopJ	NNP
cord-285262-690kpupt	202	7	)	)	-RRB-
cord-285262-690kpupt	202	8	,	,	,
cord-285262-690kpupt	202	9	an	an	DT
cord-285262-690kpupt	202	10	effector	effector	NN
cord-285262-690kpupt	202	11	protein	protein	NN
cord-285262-690kpupt	202	12	of	of	IN
cord-285262-690kpupt	202	13	the	the	DT
cord-285262-690kpupt	202	14	T3SS	T3SS	NNP
cord-285262-690kpupt	202	15	,	,	,
cord-285262-690kpupt	202	16	rapidly	rapidly	RB
cord-285262-690kpupt	202	17	kills	kill	VBZ
cord-285262-690kpupt	202	18	macrophages	macrophage	NNS
cord-285262-690kpupt	202	19	in	in	IN
cord-285262-690kpupt	202	20	a	a	DT
cord-285262-690kpupt	202	21	caspase-8	caspase-8	NNP
cord-285262-690kpupt	202	22	dependent	dependent	JJ
cord-285262-690kpupt	202	23	way	way	NN
cord-285262-690kpupt	202	24	,	,	,
cord-285262-690kpupt	202	25	which	which	WDT
cord-285262-690kpupt	202	26	occurs	occur	VBZ
cord-285262-690kpupt	202	27	independent	independent	JJ
cord-285262-690kpupt	202	28	of	of	IN
cord-285262-690kpupt	202	29	the	the	DT
cord-285262-690kpupt	202	30	canonical	canonical	JJ
cord-285262-690kpupt	202	31	inducers	inducer	NNS
cord-285262-690kpupt	202	32	of	of	IN
cord-285262-690kpupt	202	33	extrinsic	extrinsic	JJ
cord-285262-690kpupt	202	34	apoptosis	apoptosis	NN
cord-285262-690kpupt	202	35	.	.	.
cord-285262-690kpupt	203	1	In	in	IN
cord-285262-690kpupt	203	2	this	this	DT
cord-285262-690kpupt	203	3	model	model	NN
cord-285262-690kpupt	203	4	,	,	,
cord-285262-690kpupt	203	5	TLR4	TLR4	NNP
cord-285262-690kpupt	203	6	stimulation	stimulation	NN
cord-285262-690kpupt	203	7	by	by	IN
cord-285262-690kpupt	203	8	the	the	DT
cord-285262-690kpupt	203	9	pathogen	pathogen	NN
cord-285262-690kpupt	203	10	activates	activate	VBZ
cord-285262-690kpupt	203	11	the	the	DT
cord-285262-690kpupt	203	12	TRIF	TRIF	NNP
cord-285262-690kpupt	203	13	/	/	SYM
cord-285262-690kpupt	203	14	RIPK1	RIPK1	NNP
cord-285262-690kpupt	203	15	/	/	SYM
cord-285262-690kpupt	203	16	caspase-8	caspase-8	NNP
cord-285262-690kpupt	203	17	axis	axis	NN
cord-285262-690kpupt	203	18	,	,	,
cord-285262-690kpupt	203	19	which	which	WDT
cord-285262-690kpupt	203	20	leads	lead	VBZ
cord-285262-690kpupt	203	21	to	to	IN
cord-285262-690kpupt	203	22	caspase-1	caspase-1	NNP
cord-285262-690kpupt	203	23	cleavage	cleavage	NN
cord-285262-690kpupt	203	24	and	and	CC
cord-285262-690kpupt	203	25	cell	cell	NN
cord-285262-690kpupt	203	26	death	death	NN
cord-285262-690kpupt	203	27	.	.	.
cord-285262-690kpupt	204	1	Consistently	consistently	RB
cord-285262-690kpupt	204	2	,	,	,
cord-285262-690kpupt	204	3	mice	mouse	NNS
cord-285262-690kpupt	204	4	lacking	lack	VBG
cord-285262-690kpupt	204	5	caspase-8	caspase-8	NNP
cord-285262-690kpupt	204	6	and	and	CC
cord-285262-690kpupt	204	7	RIPK3	RIPK3	NNS
cord-285262-690kpupt	204	8	are	be	VBP
cord-285262-690kpupt	204	9	more	more	RBR
cord-285262-690kpupt	204	10	susceptible	susceptible	JJ
cord-285262-690kpupt	204	11	to	to	IN
cord-285262-690kpupt	204	12	the	the	DT
cord-285262-690kpupt	204	13	infection	infection	NN
cord-285262-690kpupt	204	14	,	,	,
cord-285262-690kpupt	204	15	pinpointing	pinpoint	VBG
cord-285262-690kpupt	204	16	the	the	DT
cord-285262-690kpupt	204	17	importance	importance	NN
cord-285262-690kpupt	204	18	of	of	IN
cord-285262-690kpupt	204	19	caspase-8	caspase-8	NNP
cord-285262-690kpupt	204	20	and	and	CC
cord-285262-690kpupt	204	21	RIPK	RIPK	NNP
cord-285262-690kpupt	204	22	driven	drive	VBN
cord-285262-690kpupt	204	23	signaling	signal	VBG
cord-285262-690kpupt	204	24	in	in	IN
cord-285262-690kpupt	204	25	tackling	tackle	VBG
cord-285262-690kpupt	204	26	this	this	DT
cord-285262-690kpupt	204	27	disease	disease	NN
cord-285262-690kpupt	204	28	(	(	-LRB-
cord-285262-690kpupt	204	29	Gr€	gr€	NN
cord-285262-690kpupt	204	30	obner	obner	NNP
cord-285262-690kpupt	204	31	et	et	NNP
cord-285262-690kpupt	204	32	al	al	NNP
cord-285262-690kpupt	204	33	.	.	.
cord-285262-690kpupt	205	1	,	,	,
cord-285262-690kpupt	205	2	2007	2007	CD
cord-285262-690kpupt	205	3	;	;	:
cord-285262-690kpupt	205	4	Weng	Weng	NNP
cord-285262-690kpupt	205	5	et	et	NNP
cord-285262-690kpupt	205	6	al	al	NNP
cord-285262-690kpupt	205	7	.	.	.
cord-285262-690kpupt	206	1	,	,	,
cord-285262-690kpupt	206	2	2014	2014	CD
cord-285262-690kpupt	206	3	)	)	-RRB-
cord-285262-690kpupt	206	4	.	.	.
cord-285262-690kpupt	207	1	Mycobacterium	Mycobacterium	NNP
cord-285262-690kpupt	207	2	(	(	-LRB-
cord-285262-690kpupt	207	3	M.	M.	NNP
cord-285262-690kpupt	207	4	)	)	-RRB-
cord-285262-690kpupt	207	5	tuberculosis	tuberculosis	NN
cord-285262-690kpupt	207	6	triggers	trigger	VBZ
cord-285262-690kpupt	207	7	caspase-8	caspase-8	JJ
cord-285262-690kpupt	207	8	dependent	dependent	JJ
cord-285262-690kpupt	207	9	apoptosis	apoptosis	NN
cord-285262-690kpupt	207	10	in	in	IN
cord-285262-690kpupt	207	11	human	human	JJ
cord-285262-690kpupt	207	12	monocytes	monocyte	NNS
cord-285262-690kpupt	207	13	,	,	,
cord-285262-690kpupt	207	14	which	which	WDT
cord-285262-690kpupt	207	15	is	be	VBZ
cord-285262-690kpupt	207	16	induced	induce	VBN
cord-285262-690kpupt	207	17	by	by	IN
cord-285262-690kpupt	207	18	extracellular	extracellular	JJ
cord-285262-690kpupt	207	19	bacterial	bacterial	JJ
cord-285262-690kpupt	207	20	RNA	rna	NN
cord-285262-690kpupt	207	21	fragments	fragment	NNS
cord-285262-690kpupt	207	22	detected	detect	VBN
cord-285262-690kpupt	207	23	by	by	IN
cord-285262-690kpupt	207	24	TLR3	TLR3	NNP
cord-285262-690kpupt	207	25	(	(	-LRB-
cord-285262-690kpupt	207	26	Obregón	Obregón	NNP
cord-285262-690kpupt	207	27	-	-	HYPH
cord-285262-690kpupt	207	28	Henao	Henao	NNP
cord-285262-690kpupt	207	29	et	et	NNP
cord-285262-690kpupt	207	30	al	al	NNP
cord-285262-690kpupt	207	31	.	.	NNP
cord-285262-690kpupt	207	32	,	,	,
cord-285262-690kpupt	207	33	2012	2012	CD
cord-285262-690kpupt	207	34	)	)	-RRB-
cord-285262-690kpupt	207	35	.	.	.
cord-285262-690kpupt	208	1	The	the	DT
cord-285262-690kpupt	208	2	polymorphic	polymorphic	JJ
cord-285262-690kpupt	208	3	GC	gc	NN
cord-285262-690kpupt	208	4	-	-	HYPH
cord-285262-690kpupt	208	5	rich	rich	JJ
cord-285262-690kpupt	208	6	repetitive	repetitive	JJ
cord-285262-690kpupt	208	7	sequence	sequence	NN
cord-285262-690kpupt	208	8	containing	contain	VBG
cord-285262-690kpupt	208	9	PE_PGRS33	PE_PGRS33	NNP
cord-285262-690kpupt	208	10	,	,	,
cord-285262-690kpupt	208	11	a	a	DT
cord-285262-690kpupt	208	12	surface	surface	NN
cord-285262-690kpupt	208	13	exposed	expose	VBN
cord-285262-690kpupt	208	14	protein	protein	NN
cord-285262-690kpupt	208	15	and	and	CC
cord-285262-690kpupt	208	16	the	the	DT
cord-285262-690kpupt	208	17	19-kDa	19-kda	CD
cord-285262-690kpupt	208	18	glycolipoprotein	glycolipoprotein	NNP
cord-285262-690kpupt	208	19	(	(	-LRB-
cord-285262-690kpupt	208	20	p19	p19	NN
cord-285262-690kpupt	208	21	)	)	-RRB-
cord-285262-690kpupt	208	22	of	of	IN
cord-285262-690kpupt	208	23	the	the	DT
cord-285262-690kpupt	208	24	M.	M.	NNP
cord-285262-690kpupt	208	25	tuberculosis	tuberculosis	NN
cord-285262-690kpupt	208	26	can	can	MD
cord-285262-690kpupt	208	27	both	both	DT
cord-285262-690kpupt	208	28	engage	engage	VB
cord-285262-690kpupt	208	29	TLR2	TLR2	NNP
cord-285262-690kpupt	208	30	and	and	CC
cord-285262-690kpupt	208	31	initiate	initiate	VB
cord-285262-690kpupt	208	32	apoptosis	apoptosis	NN
cord-285262-690kpupt	208	33	signal	signal	NN
cord-285262-690kpupt	208	34	-	-	HYPH
cord-285262-690kpupt	208	35	regulating	regulate	VBG
cord-285262-690kpupt	208	36	kinase-1	kinase-1	NNP
cord-285262-690kpupt	208	37	(	(	-LRB-
cord-285262-690kpupt	208	38	ASK1	ASK1	NNP
cord-285262-690kpupt	208	39	)	)	-RRB-
cord-285262-690kpupt	208	40	driven	drive	VBD
cord-285262-690kpupt	208	41	TNF	TNF	NNP
cord-285262-690kpupt	208	42	and	and	CC
cord-285262-690kpupt	208	43	TNFR	TNFR	NNP
cord-285262-690kpupt	208	44	expression	expression	NN
cord-285262-690kpupt	208	45	in	in	IN
cord-285262-690kpupt	208	46	mouse	mouse	NN
cord-285262-690kpupt	208	47	macrophages	macrophage	NNS
cord-285262-690kpupt	208	48	(	(	-LRB-
cord-285262-690kpupt	208	49	Basu	Basu	NNP
cord-285262-690kpupt	208	50	et	et	NNP
cord-285262-690kpupt	208	51	al	al	NNP
cord-285262-690kpupt	208	52	.	.	.
cord-285262-690kpupt	209	1	,	,	,
cord-285262-690kpupt	209	2	2007	2007	CD
cord-285262-690kpupt	209	3	;	;	:
cord-285262-690kpupt	209	4	López	López	NNP
cord-285262-690kpupt	209	5	et	et	NNP
cord-285262-690kpupt	209	6	al	al	NNP
cord-285262-690kpupt	209	7	.	.	NNP
cord-285262-690kpupt	209	8	,	,	,
cord-285262-690kpupt	209	9	2003	2003	CD
cord-285262-690kpupt	209	10	)	)	-RRB-
cord-285262-690kpupt	209	11	.	.	.
cord-285262-690kpupt	210	1	Finally	finally	RB
cord-285262-690kpupt	210	2	,	,	,
cord-285262-690kpupt	210	3	group	group	NN
cord-285262-690kpupt	210	4	B	B	NNP
cord-285262-690kpupt	210	5	streptococcus	streptococcus	NN
cord-285262-690kpupt	210	6	,	,	,
cord-285262-690kpupt	210	7	a	a	DT
cord-285262-690kpupt	210	8	pathogen	pathogen	NN
cord-285262-690kpupt	210	9	causing	cause	VBG
cord-285262-690kpupt	210	10	neonatal	neonatal	JJ
cord-285262-690kpupt	210	11	meningitis	meningitis	NN
cord-285262-690kpupt	210	12	,	,	,
cord-285262-690kpupt	210	13	induces	induce	VBZ
cord-285262-690kpupt	210	14	apoptosis	apoptosis	NN
cord-285262-690kpupt	210	15	via	via	IN
cord-285262-690kpupt	210	16	the	the	DT
cord-285262-690kpupt	210	17	activation	activation	NN
cord-285262-690kpupt	210	18	of	of	IN
cord-285262-690kpupt	210	19	TLR2	TLR2	NNP
cord-285262-690kpupt	210	20	,	,	,
cord-285262-690kpupt	210	21	which	which	WDT
cord-285262-690kpupt	210	22	engages	engage	VBZ
cord-285262-690kpupt	210	23	its	-PRON-	PRP$
cord-285262-690kpupt	210	24	adaptor	adaptor	NN
cord-285262-690kpupt	210	25	protein	protein	NN
cord-285262-690kpupt	210	26	myeloma	myeloma	NN
cord-285262-690kpupt	210	27	differentiation	differentiation	NN
cord-285262-690kpupt	210	28	primary	primary	JJ
cord-285262-690kpupt	210	29	response-88	response-88	NN
cord-285262-690kpupt	210	30	(	(	-LRB-
cord-285262-690kpupt	210	31	MyD88	MyD88	NNP
cord-285262-690kpupt	210	32	)	)	-RRB-
cord-285262-690kpupt	210	33	,	,	,
cord-285262-690kpupt	210	34	and	and	CC
cord-285262-690kpupt	210	35	consequently	consequently	RB
cord-285262-690kpupt	210	36	results	result	VBZ
cord-285262-690kpupt	210	37	in	in	IN
cord-285262-690kpupt	210	38	caspase-8	caspase-8	JJ
cord-285262-690kpupt	210	39	activation	activation	NN
cord-285262-690kpupt	210	40	in	in	IN
cord-285262-690kpupt	210	41	microglial	microglial	JJ
cord-285262-690kpupt	210	42	cells	cell	NNS
cord-285262-690kpupt	210	43	(	(	-LRB-
cord-285262-690kpupt	210	44	Lehnardt	Lehnardt	NNP
cord-285262-690kpupt	210	45	et	et	NNP
cord-285262-690kpupt	210	46	al	al	NNP
cord-285262-690kpupt	210	47	.	.	NNP
cord-285262-690kpupt	210	48	,	,	,
cord-285262-690kpupt	210	49	2007	2007	CD
cord-285262-690kpupt	210	50	)	)	-RRB-
cord-285262-690kpupt	210	51	.	.	.
cord-285262-690kpupt	211	1	Caspase-2	Caspase-2	NNP
cord-285262-690kpupt	211	2	is	be	VBZ
cord-285262-690kpupt	211	3	unique	unique	JJ
cord-285262-690kpupt	211	4	among	among	IN
cord-285262-690kpupt	211	5	caspases	caspase	NNS
cord-285262-690kpupt	211	6	.	.	.
cord-285262-690kpupt	212	1	It	-PRON-	PRP
cord-285262-690kpupt	212	2	exhibits	exhibit	VBZ
cord-285262-690kpupt	212	3	initiator	initiator	NN
cord-285262-690kpupt	212	4	characteristics	characteristic	NNS
cord-285262-690kpupt	212	5	structurally	structurally	RB
cord-285262-690kpupt	212	6	,	,	,
cord-285262-690kpupt	212	7	since	since	IN
cord-285262-690kpupt	212	8	it	-PRON-	PRP
cord-285262-690kpupt	212	9	has	have	VBZ
cord-285262-690kpupt	212	10	an	an	DT
cord-285262-690kpupt	212	11	N	n	CD
cord-285262-690kpupt	212	12	-	-	HYPH
cord-285262-690kpupt	212	13	terminal	terminal	JJ
cord-285262-690kpupt	212	14	caspase	caspase	NN
cord-285262-690kpupt	212	15	activation	activation	NN
cord-285262-690kpupt	212	16	and	and	CC
cord-285262-690kpupt	212	17	recruitment	recruitment	NN
cord-285262-690kpupt	212	18	domain	domain	NN
cord-285262-690kpupt	212	19	(	(	-LRB-
cord-285262-690kpupt	212	20	CARD	card	NN
cord-285262-690kpupt	212	21	)	)	-RRB-
cord-285262-690kpupt	212	22	.	.	.
cord-285262-690kpupt	213	1	In	in	IN
cord-285262-690kpupt	213	2	addition	addition	NN
cord-285262-690kpupt	213	3	,	,	,
cord-285262-690kpupt	213	4	caspase-2	caspase-2	NNP
cord-285262-690kpupt	213	5	represents	represent	VBZ
cord-285262-690kpupt	213	6	executioner	executioner	NN
cord-285262-690kpupt	213	7	features	feature	VBZ
cord-285262-690kpupt	213	8	functionally	functionally	RB
cord-285262-690kpupt	213	9	,	,	,
cord-285262-690kpupt	213	10	because	because	IN
cord-285262-690kpupt	213	11	it	-PRON-	PRP
cord-285262-690kpupt	213	12	can	can	MD
cord-285262-690kpupt	213	13	selectively	selectively	RB
cord-285262-690kpupt	213	14	cleave	cleave	VB
cord-285262-690kpupt	213	15	substrates	substrate	NNS
cord-285262-690kpupt	213	16	similar	similar	JJ
cord-285262-690kpupt	213	17	to	to	IN
cord-285262-690kpupt	213	18	that	that	DT
cord-285262-690kpupt	213	19	of	of	IN
cord-285262-690kpupt	213	20	caspase-3	caspase-3	NNP
cord-285262-690kpupt	213	21	or	or	CC
cord-285262-690kpupt	213	22	-7	-7	.
cord-285262-690kpupt	214	1	(	(	-LRB-
cord-285262-690kpupt	214	2	Olsson	Olsson	NNP
cord-285262-690kpupt	214	3	et	et	NNP
cord-285262-690kpupt	214	4	al	al	NNP
cord-285262-690kpupt	214	5	.	.	NNP
cord-285262-690kpupt	214	6	,	,	,
cord-285262-690kpupt	214	7	2015	2015	CD
cord-285262-690kpupt	214	8	)	)	-RRB-
cord-285262-690kpupt	214	9	.	.	.
cord-285262-690kpupt	215	1	Caspase-2	Caspase-2	NNP
cord-285262-690kpupt	215	2	,	,	,
cord-285262-690kpupt	215	3	along	along	IN
cord-285262-690kpupt	215	4	with	with	IN
cord-285262-690kpupt	215	5	caspase-1	caspase-1	NNP
cord-285262-690kpupt	215	6	plays	play	VBZ
cord-285262-690kpupt	215	7	a	a	DT
cord-285262-690kpupt	215	8	significant	significant	JJ
cord-285262-690kpupt	215	9	role	role	NN
cord-285262-690kpupt	215	10	in	in	IN
cord-285262-690kpupt	215	11	Brucella	Brucella	NNP
cord-285262-690kpupt	215	12	abortus	abortus	NN
cord-285262-690kpupt	215	13	and	and	CC
cord-285262-690kpupt	215	14	Brucella	Brucella	NNP
cord-285262-690kpupt	215	15	suis	suis	NN
cord-285262-690kpupt	215	16	induced	induce	VBD
cord-285262-690kpupt	215	17	cell	cell	NN
cord-285262-690kpupt	215	18	death	death	NN
cord-285262-690kpupt	215	19	(	(	-LRB-
cord-285262-690kpupt	215	20	Bronner	Bronner	NNP
cord-285262-690kpupt	215	21	et	et	NNP
cord-285262-690kpupt	215	22	al	al	NNP
cord-285262-690kpupt	215	23	.	.	NNP
cord-285262-690kpupt	215	24	,	,	,
cord-285262-690kpupt	215	25	2013	2013	CD
cord-285262-690kpupt	215	26	;	;	:
cord-285262-690kpupt	216	1	Chen	Chen	NNP
cord-285262-690kpupt	216	2	et	et	NNP
cord-285262-690kpupt	216	3	al	al	NNP
cord-285262-690kpupt	216	4	.	.	.
cord-285262-690kpupt	217	1	,	,	,
cord-285262-690kpupt	217	2	2011	2011	CD
cord-285262-690kpupt	217	3	)	)	-RRB-
cord-285262-690kpupt	217	4	.	.	.
cord-285262-690kpupt	218	1	One	one	CD
cord-285262-690kpupt	218	2	possible	possible	JJ
cord-285262-690kpupt	218	3	mechanism	mechanism	NN
cord-285262-690kpupt	218	4	of	of	IN
cord-285262-690kpupt	218	5	activation	activation	NN
cord-285262-690kpupt	218	6	is	be	VBZ
cord-285262-690kpupt	218	7	derived	derive	VBN
cord-285262-690kpupt	218	8	from	from	IN
cord-285262-690kpupt	218	9	the	the	DT
cord-285262-690kpupt	218	10	studies	study	NNS
cord-285262-690kpupt	218	11	on	on	IN
cord-285262-690kpupt	218	12	bacterial	bacterial	JJ
cord-285262-690kpupt	218	13	pore	pore	NN
cord-285262-690kpupt	218	14	forming	form	VBG
cord-285262-690kpupt	218	15	toxins	toxin	NNS
cord-285262-690kpupt	218	16	(	(	-LRB-
cord-285262-690kpupt	218	17	PFT	PFT	NNP
cord-285262-690kpupt	218	18	)	)	-RRB-
cord-285262-690kpupt	218	19	,	,	,
cord-285262-690kpupt	218	20	alpha	alpha	NN
cord-285262-690kpupt	218	21	toxin	toxin	NN
cord-285262-690kpupt	218	22	and	and	CC
cord-285262-690kpupt	218	23	aerolysin	aerolysin	NNP
cord-285262-690kpupt	218	24	secreted	secrete	VBN
cord-285262-690kpupt	218	25	by	by	IN
cord-285262-690kpupt	218	26	the	the	DT
cord-285262-690kpupt	218	27	human	human	JJ
cord-285262-690kpupt	218	28	pathogens	pathogen	NNS
cord-285262-690kpupt	218	29	Staphylococcus	Staphylococcus	NNP
cord-285262-690kpupt	218	30	aureus	aureus	NN
cord-285262-690kpupt	218	31	and	and	CC
cord-285262-690kpupt	218	32	Pseudomonas	Pseudomonas	NNP
cord-285262-690kpupt	218	33	aeruginosa	aeruginosa	NN
cord-285262-690kpupt	218	34	,	,	,
cord-285262-690kpupt	218	35	respectively	respectively	RB
cord-285262-690kpupt	218	36	.	.	.
cord-285262-690kpupt	219	1	Based	base	VBN
cord-285262-690kpupt	219	2	on	on	IN
cord-285262-690kpupt	219	3	this	this	DT
cord-285262-690kpupt	219	4	study	study	NN
cord-285262-690kpupt	219	5	,	,	,
cord-285262-690kpupt	219	6	caspase-2	caspase-2	NNP
cord-285262-690kpupt	219	7	activation	activation	NN
cord-285262-690kpupt	219	8	can	can	MD
cord-285262-690kpupt	219	9	be	be	VB
cord-285262-690kpupt	219	10	triggered	trigger	VBN
cord-285262-690kpupt	219	11	by	by	IN
cord-285262-690kpupt	219	12	the	the	DT
cord-285262-690kpupt	219	13	PFT	PFT	NNP
cord-285262-690kpupt	219	14	driven	drive	VBN
cord-285262-690kpupt	219	15	potassium	potassium	NN
cord-285262-690kpupt	219	16	efflux	efflux	NN
cord-285262-690kpupt	219	17	in	in	IN
cord-285262-690kpupt	219	18	epithelial	epithelial	JJ
cord-285262-690kpupt	219	19	cells	cell	NNS
cord-285262-690kpupt	219	20	,	,	,
cord-285262-690kpupt	219	21	which	which	WDT
cord-285262-690kpupt	219	22	facilitates	facilitate	VBZ
cord-285262-690kpupt	219	23	the	the	DT
cord-285262-690kpupt	219	24	assembly	assembly	NN
cord-285262-690kpupt	219	25	of	of	IN
cord-285262-690kpupt	219	26	a	a	DT
cord-285262-690kpupt	219	27	caspase-2	caspase-2	NNP
cord-285262-690kpupt	219	28	containing	contain	VBG
cord-285262-690kpupt	219	29	high	high	JJ
cord-285262-690kpupt	219	30	molecular	molecular	JJ
cord-285262-690kpupt	219	31	weight	weight	NN
cord-285262-690kpupt	219	32	protein	protein	NN
cord-285262-690kpupt	219	33	complex	complex	NN
cord-285262-690kpupt	219	34	(	(	-LRB-
cord-285262-690kpupt	219	35	Imre	Imre	NNP
cord-285262-690kpupt	219	36	et	et	NNP
cord-285262-690kpupt	219	37	al	al	NNP
cord-285262-690kpupt	219	38	.	.	NNP
cord-285262-690kpupt	219	39	,	,	,
cord-285262-690kpupt	219	40	2012	2012	CD
cord-285262-690kpupt	219	41	)	)	-RRB-
cord-285262-690kpupt	219	42	.	.	.
cord-285262-690kpupt	220	1	Importantly	importantly	RB
cord-285262-690kpupt	220	2	,	,	,
cord-285262-690kpupt	220	3	the	the	DT
cord-285262-690kpupt	220	4	low	low	JJ
cord-285262-690kpupt	220	5	potassium	potassium	NN
cord-285262-690kpupt	220	6	concentration	concentration	NN
cord-285262-690kpupt	220	7	triggered	trigger	VBD
cord-285262-690kpupt	220	8	activation	activation	NN
cord-285262-690kpupt	220	9	of	of	IN
cord-285262-690kpupt	220	10	caspases	caspase	NNS
cord-285262-690kpupt	220	11	is	be	VBZ
cord-285262-690kpupt	220	12	not	not	RB
cord-285262-690kpupt	220	13	without	without	IN
cord-285262-690kpupt	220	14	precedent	precedent	NN
cord-285262-690kpupt	220	15	in	in	IN
cord-285262-690kpupt	220	16	the	the	DT
cord-285262-690kpupt	220	17	literature	literature	NN
cord-285262-690kpupt	220	18	.	.	.
cord-285262-690kpupt	221	1	Though	though	RB
cord-285262-690kpupt	221	2	,	,	,
cord-285262-690kpupt	221	3	the	the	DT
cord-285262-690kpupt	221	4	role	role	NN
cord-285262-690kpupt	221	5	of	of	IN
cord-285262-690kpupt	221	6	potassium	potassium	NN
cord-285262-690kpupt	221	7	efflux	efflux	NN
cord-285262-690kpupt	221	8	has	have	VBZ
cord-285262-690kpupt	221	9	been	be	VBN
cord-285262-690kpupt	221	10	demonstrated	demonstrate	VBN
cord-285262-690kpupt	221	11	in	in	IN
cord-285262-690kpupt	221	12	terms	term	NNS
cord-285262-690kpupt	221	13	of	of	IN
cord-285262-690kpupt	221	14	the	the	DT
cord-285262-690kpupt	221	15	pro	pro	JJ
cord-285262-690kpupt	221	16	-	-	JJ
cord-285262-690kpupt	221	17	inflammatory	inflammatory	JJ
cord-285262-690kpupt	221	18	caspase-1	caspase-1	NNP
cord-285262-690kpupt	221	19	activation	activation	NN
cord-285262-690kpupt	221	20	in	in	IN
cord-285262-690kpupt	221	21	immune	immune	JJ
cord-285262-690kpupt	221	22	cells	cell	NNS
cord-285262-690kpupt	221	23	(	(	-LRB-
cord-285262-690kpupt	221	24	see	see	VB
cord-285262-690kpupt	221	25	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	221	26	)	)	-RRB-
cord-285262-690kpupt	221	27	,	,	,
cord-285262-690kpupt	221	28	it	-PRON-	PRP
cord-285262-690kpupt	221	29	is	be	VBZ
cord-285262-690kpupt	221	30	not	not	RB
cord-285262-690kpupt	221	31	clear	clear	JJ
cord-285262-690kpupt	221	32	whether	whether	IN
cord-285262-690kpupt	221	33	caspase-2	caspase-2	NNP
cord-285262-690kpupt	221	34	activation	activation	NN
cord-285262-690kpupt	221	35	takes	take	VBZ
cord-285262-690kpupt	221	36	place	place	NN
cord-285262-690kpupt	221	37	in	in	IN
cord-285262-690kpupt	221	38	an	an	DT
cord-285262-690kpupt	221	39	inflammasome	inflammasome	NN
cord-285262-690kpupt	221	40	-	-	HYPH
cord-285262-690kpupt	221	41	like	like	JJ
cord-285262-690kpupt	221	42	complex	complex	NN
cord-285262-690kpupt	221	43	in	in	IN
cord-285262-690kpupt	221	44	response	response	NN
cord-285262-690kpupt	221	45	to	to	IN
cord-285262-690kpupt	221	46	pathogen	pathogen	NN
cord-285262-690kpupt	221	47	insults	insult	NNS
cord-285262-690kpupt	221	48	in	in	IN
cord-285262-690kpupt	221	49	epithelial	epithelial	JJ
cord-285262-690kpupt	221	50	cells	cell	NNS
cord-285262-690kpupt	221	51	.	.	.
cord-285262-690kpupt	222	1	Several	several	JJ
cord-285262-690kpupt	222	2	pathogenic	pathogenic	JJ
cord-285262-690kpupt	222	3	bacteria	bacteria	NNS
cord-285262-690kpupt	222	4	developed	develop	VBD
cord-285262-690kpupt	222	5	strategies	strategy	NNS
cord-285262-690kpupt	222	6	to	to	TO
cord-285262-690kpupt	222	7	evade	evade	VB
cord-285262-690kpupt	222	8	the	the	DT
cord-285262-690kpupt	222	9	apoptotic	apoptotic	JJ
cord-285262-690kpupt	222	10	demolition	demolition	NN
cord-285262-690kpupt	222	11	.	.	.
cord-285262-690kpupt	223	1	Francisella	Francisella	NNP
cord-285262-690kpupt	223	2	tularensis	tularensis	NNP
cord-285262-690kpupt	223	3	,	,	,
cord-285262-690kpupt	223	4	a	a	DT
cord-285262-690kpupt	223	5	highly	highly	RB
cord-285262-690kpupt	223	6	virulent	virulent	JJ
cord-285262-690kpupt	223	7	Gram	gram	NN
cord-285262-690kpupt	223	8	-	-	HYPH
cord-285262-690kpupt	223	9	negative	negative	JJ
cord-285262-690kpupt	223	10	pathogen	pathogen	NN
cord-285262-690kpupt	223	11	inhibits	inhibit	VBZ
cord-285262-690kpupt	223	12	apoptosis	apoptosis	NN
cord-285262-690kpupt	223	13	by	by	IN
cord-285262-690kpupt	223	14	retaining	retain	VBG
cord-285262-690kpupt	223	15	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	223	16	integrity	integrity	NN
cord-285262-690kpupt	223	17	via	via	IN
cord-285262-690kpupt	223	18	the	the	DT
cord-285262-690kpupt	223	19	inhibition	inhibition	NN
cord-285262-690kpupt	223	20	of	of	IN
cord-285262-690kpupt	223	21	BID	BID	NNP
cord-285262-690kpupt	223	22	processing	processing	NN
cord-285262-690kpupt	223	23	and	and	CC
cord-285262-690kpupt	223	24	BAX	BAX	NNP
cord-285262-690kpupt	223	25	translocation	translocation	NN
cord-285262-690kpupt	223	26	,	,	,
cord-285262-690kpupt	223	27	and	and	CC
cord-285262-690kpupt	223	28	successfully	successfully	RB
cord-285262-690kpupt	223	29	extends	extend	VBZ
cord-285262-690kpupt	223	30	the	the	DT
cord-285262-690kpupt	223	31	lifespan	lifespan	NN
cord-285262-690kpupt	223	32	of	of	IN
cord-285262-690kpupt	223	33	the	the	DT
cord-285262-690kpupt	223	34	infected	infected	JJ
cord-285262-690kpupt	223	35	neutrophils	neutrophil	NNS
cord-285262-690kpupt	223	36	(	(	-LRB-
cord-285262-690kpupt	223	37	McCracken	McCracken	NNP
cord-285262-690kpupt	223	38	et	et	NNP
cord-285262-690kpupt	223	39	al	al	NNP
cord-285262-690kpupt	223	40	.	.	NNP
cord-285262-690kpupt	223	41	,	,	,
cord-285262-690kpupt	223	42	2016	2016	CD
cord-285262-690kpupt	223	43	)	)	-RRB-
cord-285262-690kpupt	223	44	.	.	.
cord-285262-690kpupt	224	1	Helicobacter	Helicobacter	NNP
cord-285262-690kpupt	224	2	pylori	pylori	NN
cord-285262-690kpupt	224	3	leads	lead	VBZ
cord-285262-690kpupt	224	4	to	to	IN
cord-285262-690kpupt	224	5	a	a	DT
cord-285262-690kpupt	224	6	persistent	persistent	JJ
cord-285262-690kpupt	224	7	,	,	,
cord-285262-690kpupt	224	8	yet	yet	CC
cord-285262-690kpupt	224	9	asymptomatic	asymptomatic	JJ
cord-285262-690kpupt	224	10	infection	infection	NN
cord-285262-690kpupt	224	11	,	,	,
cord-285262-690kpupt	224	12	which	which	WDT
cord-285262-690kpupt	224	13	,	,	,
cord-285262-690kpupt	224	14	however	however	RB
cord-285262-690kpupt	224	15	,	,	,
cord-285262-690kpupt	224	16	can	can	MD
cord-285262-690kpupt	224	17	increase	increase	VB
cord-285262-690kpupt	224	18	the	the	DT
cord-285262-690kpupt	224	19	incidence	incidence	NN
cord-285262-690kpupt	224	20	of	of	IN
cord-285262-690kpupt	224	21	the	the	DT
cord-285262-690kpupt	224	22	chronic	chronic	JJ
cord-285262-690kpupt	224	23	gastritis	gastritis	NN
cord-285262-690kpupt	224	24	and	and	CC
cord-285262-690kpupt	224	25	the	the	DT
cord-285262-690kpupt	224	26	gastric	gastric	JJ
cord-285262-690kpupt	224	27	adenocarcinoma	adenocarcinoma	NN
cord-285262-690kpupt	224	28	.	.	.
cord-285262-690kpupt	225	1	This	this	DT
cord-285262-690kpupt	225	2	pathogen	pathogen	NN
cord-285262-690kpupt	225	3	inhibits	inhibit	VBZ
cord-285262-690kpupt	225	4	the	the	DT
cord-285262-690kpupt	225	5	anti	anti	JJ
cord-285262-690kpupt	225	6	-	-	JJ
cord-285262-690kpupt	225	7	bacterial	bacterial	JJ
cord-285262-690kpupt	225	8	and	and	CC
cord-285262-690kpupt	225	9	cell	cell	NN
cord-285262-690kpupt	225	10	death	death	NN
cord-285262-690kpupt	225	11	responses	response	NNS
cord-285262-690kpupt	225	12	simultaneously	simultaneously	RB
cord-285262-690kpupt	225	13	by	by	IN
cord-285262-690kpupt	225	14	enhancing	enhance	VBG
cord-285262-690kpupt	225	15	the	the	DT
cord-285262-690kpupt	225	16	level	level	NN
cord-285262-690kpupt	225	17	of	of	IN
cord-285262-690kpupt	225	18	ubiquitin	ubiquitin	NN
cord-285262-690kpupt	225	19	-	-	HYPH
cord-285262-690kpupt	225	20	editing	editing	NN
cord-285262-690kpupt	225	21	enzyme	enzyme	NN
cord-285262-690kpupt	225	22	A20	A20	NNP
cord-285262-690kpupt	225	23	,	,	,
cord-285262-690kpupt	225	24	which	which	WDT
cord-285262-690kpupt	225	25	in	in	IN
cord-285262-690kpupt	225	26	turn	turn	NN
cord-285262-690kpupt	225	27	bi	bi	NNP
cord-285262-690kpupt	225	28	-	-	NN
cord-285262-690kpupt	225	29	functionally	functionally	RB
cord-285262-690kpupt	225	30	blocks	block	VBZ
cord-285262-690kpupt	225	31	both	both	CC
cord-285262-690kpupt	225	32	the	the	DT
cord-285262-690kpupt	225	33	NF	nf	NN
cord-285262-690kpupt	225	34	-	-	HYPH
cord-285262-690kpupt	225	35	κB	κb	CD
cord-285262-690kpupt	225	36	activity	activity	NN
cord-285262-690kpupt	225	37	and	and	CC
cord-285262-690kpupt	225	38	the	the	DT
cord-285262-690kpupt	225	39	caspase-8	caspase-8	NNP
cord-285262-690kpupt	225	40	activity	activity	NN
cord-285262-690kpupt	226	1	(	(	-LRB-
cord-285262-690kpupt	226	2	Lim	Lim	NNP
cord-285262-690kpupt	226	3	et	et	NNP
cord-285262-690kpupt	226	4	al	al	NNP
cord-285262-690kpupt	226	5	.	.	NNP
cord-285262-690kpupt	226	6	,	,	,
cord-285262-690kpupt	226	7	2017	2017	CD
cord-285262-690kpupt	226	8	)	)	-RRB-
cord-285262-690kpupt	226	9	.	.	.
cord-285262-690kpupt	227	1	Enteropathogenic	Enteropathogenic	NNP
cord-285262-690kpupt	227	2	Escherichia	escherichia	NN
cord-285262-690kpupt	227	3	coli	coli	NNS
cord-285262-690kpupt	227	4	(	(	-LRB-
cord-285262-690kpupt	227	5	EPEC	EPEC	NNP
cord-285262-690kpupt	227	6	)	)	-RRB-
cord-285262-690kpupt	227	7	transports	transport	VBZ
cord-285262-690kpupt	227	8	effector	effector	NN
cord-285262-690kpupt	227	9	proteins	protein	NNS
cord-285262-690kpupt	227	10	directly	directly	RB
cord-285262-690kpupt	227	11	into	into	IN
cord-285262-690kpupt	227	12	the	the	DT
cord-285262-690kpupt	227	13	cytosol	cytosol	NN
cord-285262-690kpupt	227	14	of	of	IN
cord-285262-690kpupt	227	15	infected	infected	JJ
cord-285262-690kpupt	227	16	cells	cell	NNS
cord-285262-690kpupt	227	17	by	by	IN
cord-285262-690kpupt	227	18	utilizing	utilize	VBG
cord-285262-690kpupt	227	19	the	the	DT
cord-285262-690kpupt	227	20	T3SS	t3ss	NN
cord-285262-690kpupt	227	21	.	.	.
cord-285262-690kpupt	228	1	One	one	CD
cord-285262-690kpupt	228	2	of	of	IN
cord-285262-690kpupt	228	3	these	these	DT
cord-285262-690kpupt	228	4	effector	effector	NN
cord-285262-690kpupt	228	5	proteins	protein	NNS
cord-285262-690kpupt	228	6	is	be	VBZ
cord-285262-690kpupt	229	1	the	the	DT
cord-285262-690kpupt	229	2	non	non	JJ
cord-285262-690kpupt	229	3	-	-	JJ
cord-285262-690kpupt	229	4	locus	locus	NN
cord-285262-690kpupt	229	5	of	of	IN
cord-285262-690kpupt	229	6	enterocyte	enterocyte	NNP
cord-285262-690kpupt	229	7	effacement	effacement	NNP
cord-285262-690kpupt	229	8	encoded	encode	VBD
cord-285262-690kpupt	229	9	effector	effector	NN
cord-285262-690kpupt	229	10	B1	b1	NN
cord-285262-690kpupt	229	11	(	(	-LRB-
cord-285262-690kpupt	229	12	NLeB1	NLeB1	NNP
cord-285262-690kpupt	229	13	)	)	-RRB-
cord-285262-690kpupt	229	14	.	.	.
cord-285262-690kpupt	230	1	NleB1	NleB1	NNP
cord-285262-690kpupt	230	2	transfers	transfer	VBZ
cord-285262-690kpupt	230	3	an	an	DT
cord-285262-690kpupt	230	4	N	n	CD
cord-285262-690kpupt	230	5	-	-	HYPH
cord-285262-690kpupt	230	6	acetyl	acetyl	NN
cord-285262-690kpupt	230	7	-	-	HYPH
cord-285262-690kpupt	230	8	glucosamine	glucosamine	NN
cord-285262-690kpupt	230	9	residue	residue	NN
cord-285262-690kpupt	230	10	to	to	IN
cord-285262-690kpupt	230	11	Arg117	arg117	CD
cord-285262-690kpupt	230	12	in	in	IN
cord-285262-690kpupt	230	13	the	the	DT
cord-285262-690kpupt	230	14	death	death	NN
cord-285262-690kpupt	230	15	domain	domain	NN
cord-285262-690kpupt	230	16	of	of	IN
cord-285262-690kpupt	230	17	FADD	FADD	NNP
cord-285262-690kpupt	230	18	and	and	CC
cord-285262-690kpupt	230	19	inhibits	inhibit	VBZ
cord-285262-690kpupt	230	20	the	the	DT
cord-285262-690kpupt	230	21	FADD	FADD	NNP
cord-285262-690kpupt	230	22	dependent	dependent	JJ
cord-285262-690kpupt	230	23	caspase-8	caspase-8	NNP
cord-285262-690kpupt	230	24	activation	activation	NN
cord-285262-690kpupt	230	25	(	(	-LRB-
cord-285262-690kpupt	230	26	Pearson	Pearson	NNP
cord-285262-690kpupt	230	27	et	et	NNP
cord-285262-690kpupt	230	28	al	al	NNP
cord-285262-690kpupt	230	29	.	.	NNP
cord-285262-690kpupt	230	30	,	,	,
cord-285262-690kpupt	230	31	2013	2013	CD
cord-285262-690kpupt	230	32	)	)	-RRB-
cord-285262-690kpupt	230	33	.	.	.
cord-285262-690kpupt	231	1	Chlamydia	Chlamydia	NNP
cord-285262-690kpupt	231	2	trachomatis	trachomatis	NN
cord-285262-690kpupt	231	3	is	be	VBZ
cord-285262-690kpupt	231	4	an	an	DT
cord-285262-690kpupt	231	5	obligate	obligate	JJ
cord-285262-690kpupt	231	6	intracellular	intracellular	JJ
cord-285262-690kpupt	231	7	pathogen	pathogen	NN
cord-285262-690kpupt	231	8	with	with	IN
cord-285262-690kpupt	231	9	medical	medical	JJ
cord-285262-690kpupt	231	10	relevance	relevance	NN
cord-285262-690kpupt	231	11	,	,	,
cord-285262-690kpupt	231	12	which	which	WDT
cord-285262-690kpupt	231	13	interferes	interfere	VBZ
cord-285262-690kpupt	231	14	with	with	IN
cord-285262-690kpupt	231	15	apoptosis	apoptosis	NN
cord-285262-690kpupt	231	16	by	by	IN
cord-285262-690kpupt	231	17	blocking	block	VBG
cord-285262-690kpupt	231	18	the	the	DT
cord-285262-690kpupt	231	19	internalization	internalization	NN
cord-285262-690kpupt	231	20	of	of	IN
cord-285262-690kpupt	231	21	the	the	DT
cord-285262-690kpupt	231	22	cell	cell	NN
cord-285262-690kpupt	231	23	death	death	NN
cord-285262-690kpupt	231	24	receptor	receptor	NN
cord-285262-690kpupt	231	25	TNFR1	TNFR1	NNP
cord-285262-690kpupt	231	26	.	.	.
cord-285262-690kpupt	232	1	This	this	DT
cord-285262-690kpupt	232	2	mechanism	mechanism	NN
cord-285262-690kpupt	232	3	renders	render	VBZ
cord-285262-690kpupt	232	4	the	the	DT
cord-285262-690kpupt	232	5	specific	specific	JJ
cord-285262-690kpupt	232	6	blockage	blockage	NN
cord-285262-690kpupt	232	7	of	of	IN
cord-285262-690kpupt	232	8	the	the	DT
cord-285262-690kpupt	232	9	apoptotic	apoptotic	JJ
cord-285262-690kpupt	232	10	signaling	signaling	NN
cord-285262-690kpupt	232	11	but	but	CC
cord-285262-690kpupt	232	12	preserves	preserve	VBZ
cord-285262-690kpupt	232	13	the	the	DT
cord-285262-690kpupt	232	14	function	function	NN
cord-285262-690kpupt	232	15	of	of	IN
cord-285262-690kpupt	232	16	the	the	DT
cord-285262-690kpupt	232	17	NF	nf	NN
cord-285262-690kpupt	232	18	-	-	HYPH
cord-285262-690kpupt	232	19	κB	κB	NNP
cord-285262-690kpupt	232	20	signaling	signaling	NN
cord-285262-690kpupt	232	21	of	of	IN
cord-285262-690kpupt	233	1	the	the	DT
cord-285262-690kpupt	233	2	TNFR1	tnfr1	XX
cord-285262-690kpupt	233	3	(	(	-LRB-
cord-285262-690kpupt	233	4	Waguia	Waguia	NNP
cord-285262-690kpupt	233	5	Kontchou	Kontchou	NNP
cord-285262-690kpupt	233	6	et	et	NNP
cord-285262-690kpupt	233	7	al	al	NNP
cord-285262-690kpupt	233	8	.	.	NNP
cord-285262-690kpupt	233	9	,	,	,
cord-285262-690kpupt	233	10	2016	2016	CD
cord-285262-690kpupt	233	11	)	)	-RRB-
cord-285262-690kpupt	233	12	.	.	.
cord-285262-690kpupt	234	1	In	in	IN
cord-285262-690kpupt	234	2	the	the	DT
cord-285262-690kpupt	234	3	previous	previous	JJ
cord-285262-690kpupt	234	4	chapter	chapter	NN
cord-285262-690kpupt	234	5	,	,	,
cord-285262-690kpupt	234	6	we	-PRON-	PRP
cord-285262-690kpupt	234	7	have	have	VBP
cord-285262-690kpupt	234	8	seen	see	VBN
cord-285262-690kpupt	234	9	several	several	JJ
cord-285262-690kpupt	234	10	examples	example	NNS
cord-285262-690kpupt	234	11	for	for	IN
cord-285262-690kpupt	234	12	apoptosis	apoptosis	NN
cord-285262-690kpupt	234	13	being	be	VBG
cord-285262-690kpupt	234	14	induced	induce	VBN
cord-285262-690kpupt	234	15	in	in	IN
cord-285262-690kpupt	234	16	response	response	NN
cord-285262-690kpupt	234	17	to	to	IN
cord-285262-690kpupt	234	18	PAMPs	pamp	NNS
cord-285262-690kpupt	234	19	.	.	.
cord-285262-690kpupt	235	1	Nevertheless	nevertheless	RB
cord-285262-690kpupt	235	2	,	,	,
cord-285262-690kpupt	235	3	apoptosis	apoptosis	NN
cord-285262-690kpupt	235	4	in	in	IN
cord-285262-690kpupt	235	5	many	many	JJ
cord-285262-690kpupt	235	6	circumstances	circumstance	NNS
cord-285262-690kpupt	235	7	does	do	VBZ
cord-285262-690kpupt	235	8	not	not	RB
cord-285262-690kpupt	235	9	support	support	VB
cord-285262-690kpupt	235	10	the	the	DT
cord-285262-690kpupt	235	11	immune	immune	JJ
cord-285262-690kpupt	235	12	stimulation	stimulation	NN
cord-285262-690kpupt	235	13	,	,	,
cord-285262-690kpupt	235	14	which	which	WDT
cord-285262-690kpupt	235	15	on	on	IN
cord-285262-690kpupt	235	16	the	the	DT
cord-285262-690kpupt	235	17	long	long	JJ
cord-285262-690kpupt	235	18	run	run	NN
cord-285262-690kpupt	235	19	assists	assist	VBZ
cord-285262-690kpupt	235	20	the	the	DT
cord-285262-690kpupt	235	21	pathogen	pathogen	NN
cord-285262-690kpupt	235	22	to	to	TO
cord-285262-690kpupt	235	23	evade	evade	VB
cord-285262-690kpupt	235	24	the	the	DT
cord-285262-690kpupt	235	25	counterattacks	counterattack	NNS
cord-285262-690kpupt	235	26	of	of	IN
cord-285262-690kpupt	235	27	the	the	DT
cord-285262-690kpupt	235	28	immune	immune	JJ
cord-285262-690kpupt	235	29	system	system	NN
cord-285262-690kpupt	235	30	.	.	.
cord-285262-690kpupt	236	1	Necroptosis	Necroptosis	NNP
cord-285262-690kpupt	236	2	represents	represent	VBZ
cord-285262-690kpupt	236	3	an	an	DT
cord-285262-690kpupt	236	4	immunogenic	immunogenic	JJ
cord-285262-690kpupt	236	5	cell	cell	NN
cord-285262-690kpupt	236	6	death	death	NN
cord-285262-690kpupt	236	7	modality	modality	NN
cord-285262-690kpupt	236	8	.	.	.
cord-285262-690kpupt	237	1	This	this	DT
cord-285262-690kpupt	237	2	nonapoptotic	nonapoptotic	NNP
cord-285262-690kpupt	237	3	programmed	program	VBD
cord-285262-690kpupt	237	4	cell	cell	NN
cord-285262-690kpupt	237	5	death	death	NN
cord-285262-690kpupt	237	6	form	form	NN
cord-285262-690kpupt	237	7	,	,	,
cord-285262-690kpupt	237	8	that	that	IN
cord-285262-690kpupt	237	9	morphologically	morphologically	RB
cord-285262-690kpupt	237	10	resembles	resemble	VBZ
cord-285262-690kpupt	237	11	necrosis	necrosis	NN
cord-285262-690kpupt	237	12	,	,	,
cord-285262-690kpupt	237	13	has	have	VBZ
cord-285262-690kpupt	237	14	gained	gain	VBN
cord-285262-690kpupt	237	15	attention	attention	NN
cord-285262-690kpupt	237	16	in	in	IN
cord-285262-690kpupt	237	17	the	the	DT
cord-285262-690kpupt	237	18	past	past	JJ
cord-285262-690kpupt	237	19	2	2	CD
cord-285262-690kpupt	237	20	decades	decade	NNS
cord-285262-690kpupt	237	21	(	(	-LRB-
cord-285262-690kpupt	237	22	Degterev	Degterev	NNP
cord-285262-690kpupt	237	23	et	et	FW
cord-285262-690kpupt	237	24	al	al	NNP
cord-285262-690kpupt	237	25	.	.	NNP
cord-285262-690kpupt	237	26	,	,	,
cord-285262-690kpupt	237	27	2005	2005	CD
cord-285262-690kpupt	237	28	;	;	:
cord-285262-690kpupt	238	1	Vercammen	Vercammen	NNP
cord-285262-690kpupt	238	2	et	et	FW
cord-285262-690kpupt	238	3	al	al	NNP
cord-285262-690kpupt	238	4	.	.	NNP
cord-285262-690kpupt	238	5	,	,	,
cord-285262-690kpupt	238	6	1998	1998	CD
cord-285262-690kpupt	238	7	)	)	-RRB-
cord-285262-690kpupt	238	8	,	,	,
cord-285262-690kpupt	238	9	and	and	CC
cord-285262-690kpupt	239	1	its	-PRON-	PRP$
cord-285262-690kpupt	239	2	relevance	relevance	NN
cord-285262-690kpupt	239	3	in	in	IN
cord-285262-690kpupt	239	4	infection	infection	NN
cord-285262-690kpupt	239	5	has	have	VBZ
cord-285262-690kpupt	239	6	been	be	VBN
cord-285262-690kpupt	239	7	recognized	recognize	VBN
cord-285262-690kpupt	239	8	only	only	RB
cord-285262-690kpupt	239	9	recently	recently	RB
cord-285262-690kpupt	239	10	(	(	-LRB-
cord-285262-690kpupt	239	11	Pan	Pan	NNP
cord-285262-690kpupt	239	12	et	et	FW
cord-285262-690kpupt	239	13	al	al	NNP
cord-285262-690kpupt	239	14	.	.	NNP
cord-285262-690kpupt	239	15	,	,	,
cord-285262-690kpupt	239	16	2014	2014	CD
cord-285262-690kpupt	239	17	)	)	-RRB-
cord-285262-690kpupt	239	18	.	.	.
cord-285262-690kpupt	240	1	In	in	IN
cord-285262-690kpupt	240	2	contrast	contrast	NN
cord-285262-690kpupt	240	3	to	to	IN
cord-285262-690kpupt	240	4	apoptosis	apoptosis	NN
cord-285262-690kpupt	240	5	,	,	,
cord-285262-690kpupt	240	6	necroptosis	necroptosis	NNP
cord-285262-690kpupt	240	7	is	be	VBZ
cord-285262-690kpupt	240	8	characterized	characterize	VBN
cord-285262-690kpupt	240	9	by	by	IN
cord-285262-690kpupt	240	10	swelling	swell	VBG
cord-285262-690kpupt	240	11	of	of	IN
cord-285262-690kpupt	240	12	the	the	DT
cord-285262-690kpupt	240	13	cytoplasm	cytoplasm	NN
cord-285262-690kpupt	240	14	,	,	,
cord-285262-690kpupt	240	15	osmotic	osmotic	JJ
cord-285262-690kpupt	240	16	perturbations	perturbation	NNS
cord-285262-690kpupt	240	17	and	and	CC
cord-285262-690kpupt	240	18	the	the	DT
cord-285262-690kpupt	240	19	early	early	JJ
cord-285262-690kpupt	240	20	rupture	rupture	NN
cord-285262-690kpupt	240	21	of	of	IN
cord-285262-690kpupt	240	22	the	the	DT
cord-285262-690kpupt	240	23	cytoplasm	cytoplasm	NN
cord-285262-690kpupt	240	24	membrane	membrane	NN
cord-285262-690kpupt	240	25	,	,	,
cord-285262-690kpupt	240	26	resulting	result	VBG
cord-285262-690kpupt	240	27	in	in	IN
cord-285262-690kpupt	240	28	the	the	DT
cord-285262-690kpupt	240	29	release	release	NN
cord-285262-690kpupt	240	30	of	of	IN
cord-285262-690kpupt	240	31	DAMPs	damp	NNS
cord-285262-690kpupt	240	32	into	into	IN
cord-285262-690kpupt	240	33	the	the	DT
cord-285262-690kpupt	240	34	extracellular	extracellular	JJ
cord-285262-690kpupt	240	35	space	space	NN
cord-285262-690kpupt	240	36	.	.	.
cord-285262-690kpupt	241	1	Receptor	receptor	NN
cord-285262-690kpupt	241	2	interacting	interact	VBG
cord-285262-690kpupt	241	3	protein	protein	NN
cord-285262-690kpupt	241	4	kinase-1	kinase-1	NNP
cord-285262-690kpupt	242	1	and	and	CC
cord-285262-690kpupt	242	2	-3	-3	NNP
cord-285262-690kpupt	242	3	(	(	-LRB-
cord-285262-690kpupt	242	4	RIPK1	RIPK1	NNP
cord-285262-690kpupt	242	5	and	and	CC
cord-285262-690kpupt	242	6	RIPK3	RIPK3	NNP
cord-285262-690kpupt	242	7	)	)	-RRB-
cord-285262-690kpupt	242	8	play	play	VBP
cord-285262-690kpupt	242	9	indispensable	indispensable	JJ
cord-285262-690kpupt	242	10	role	role	NN
cord-285262-690kpupt	242	11	in	in	IN
cord-285262-690kpupt	242	12	conducting	conduct	VBG
cord-285262-690kpupt	242	13	necroptosis	necroptosis	NN
cord-285262-690kpupt	242	14	signaling	signaling	NN
cord-285262-690kpupt	242	15	.	.	.
cord-285262-690kpupt	243	1	RIPKs	RIPKs	NNP
cord-285262-690kpupt	243	2	interact	interact	VB
cord-285262-690kpupt	243	3	via	via	IN
cord-285262-690kpupt	243	4	their	-PRON-	PRP$
cord-285262-690kpupt	243	5	RIPK	RIPK	NNP
cord-285262-690kpupt	243	6	homotypic	homotypic	JJ
cord-285262-690kpupt	243	7	interaction	interaction	NN
cord-285262-690kpupt	243	8	motif	motif	NN
cord-285262-690kpupt	243	9	(	(	-LRB-
cord-285262-690kpupt	243	10	RHIM	RHIM	NNP
cord-285262-690kpupt	243	11	)	)	-RRB-
cord-285262-690kpupt	243	12	domains	domain	NNS
cord-285262-690kpupt	243	13	.	.	.
cord-285262-690kpupt	244	1	The	the	DT
cord-285262-690kpupt	244	2	most	most	RBS
cord-285262-690kpupt	244	3	studied	study	VBN
cord-285262-690kpupt	244	4	pathway	pathway	NN
cord-285262-690kpupt	244	5	,	,	,
cord-285262-690kpupt	244	6	by	by	IN
cord-285262-690kpupt	244	7	which	which	WDT
cord-285262-690kpupt	244	8	RIPK	RIPK	NNP
cord-285262-690kpupt	244	9	dependent	dependent	JJ
cord-285262-690kpupt	244	10	necroptosis	necroptosis	NN
cord-285262-690kpupt	244	11	can	can	MD
cord-285262-690kpupt	244	12	be	be	VB
cord-285262-690kpupt	244	13	triggered	trigger	VBN
cord-285262-690kpupt	244	14	is	be	VBZ
cord-285262-690kpupt	244	15	the	the	DT
cord-285262-690kpupt	244	16	TNFR1	TNFR1	NNP
cord-285262-690kpupt	244	17	induced	induce	VBN
cord-285262-690kpupt	244	18	pathway	pathway	NN
cord-285262-690kpupt	244	19	.	.	.
cord-285262-690kpupt	245	1	TNFR1	TNFR1	NNP
cord-285262-690kpupt	245	2	activation	activation	NN
cord-285262-690kpupt	245	3	primarily	primarily	RB
cord-285262-690kpupt	245	4	results	result	VBZ
cord-285262-690kpupt	245	5	in	in	IN
cord-285262-690kpupt	245	6	NF	nf	NN
cord-285262-690kpupt	245	7	-	-	HYPH
cord-285262-690kpupt	245	8	κB	κB	NNP
cord-285262-690kpupt	245	9	dependent	dependent	JJ
cord-285262-690kpupt	245	10	pro	pro	JJ
cord-285262-690kpupt	245	11	-	-	JJ
cord-285262-690kpupt	245	12	proliferative	proliferative	JJ
cord-285262-690kpupt	245	13	response	response	NN
cord-285262-690kpupt	245	14	.	.	.
cord-285262-690kpupt	246	1	Upon	upon	IN
cord-285262-690kpupt	246	2	the	the	DT
cord-285262-690kpupt	246	3	ligation	ligation	NN
cord-285262-690kpupt	246	4	of	of	IN
cord-285262-690kpupt	246	5	TNFR1	TNFR1	NNP
cord-285262-690kpupt	246	6	the	the	DT
cord-285262-690kpupt	246	7	formation	formation	NN
cord-285262-690kpupt	246	8	of	of	IN
cord-285262-690kpupt	246	9	the	the	DT
cord-285262-690kpupt	246	10	so	so	RB
cord-285262-690kpupt	246	11	-	-	HYPH
cord-285262-690kpupt	246	12	called	call	VBN
cord-285262-690kpupt	246	13	complex	complex	NN
cord-285262-690kpupt	246	14	-	-	:
cord-285262-690kpupt	246	15	I	-PRON-	PRP
cord-285262-690kpupt	246	16	takes	take	VBZ
cord-285262-690kpupt	246	17	place	place	NN
cord-285262-690kpupt	246	18	,	,	,
cord-285262-690kpupt	246	19	consisting	consist	VBG
cord-285262-690kpupt	246	20	of	of	IN
cord-285262-690kpupt	246	21	the	the	DT
cord-285262-690kpupt	246	22	adaptor	adaptor	NN
cord-285262-690kpupt	246	23	proteins	protein	NNS
cord-285262-690kpupt	246	24	TRADD	TRADD	NNP
cord-285262-690kpupt	246	25	,	,	,
cord-285262-690kpupt	246	26	TRAF2	TRAF2	NNP
cord-285262-690kpupt	246	27	,	,	,
cord-285262-690kpupt	246	28	cIAP	ciap	NN
cord-285262-690kpupt	246	29	and	and	CC
cord-285262-690kpupt	246	30	ubiquitinated	ubiquitinated	JJ
cord-285262-690kpupt	246	31	RIPK1	RIPK1	NNP
cord-285262-690kpupt	247	1	(	(	-LRB-
cord-285262-690kpupt	247	2	Fig	Fig	NNP
cord-285262-690kpupt	247	3	.	.	.
cord-285262-690kpupt	248	1	2	2	LS
cord-285262-690kpupt	248	2	)	)	-RRB-
cord-285262-690kpupt	249	1	(	(	-LRB-
cord-285262-690kpupt	249	2	Wilson	Wilson	NNP
cord-285262-690kpupt	249	3	et	et	NNP
cord-285262-690kpupt	249	4	al	al	NNP
cord-285262-690kpupt	249	5	.	.	NNP
cord-285262-690kpupt	249	6	,	,	,
cord-285262-690kpupt	249	7	2009	2009	CD
cord-285262-690kpupt	249	8	)	)	-RRB-
cord-285262-690kpupt	249	9	.	.	.
cord-285262-690kpupt	250	1	Once	once	RB
cord-285262-690kpupt	250	2	,	,	,
cord-285262-690kpupt	250	3	the	the	DT
cord-285262-690kpupt	250	4	pro	pro	JJ
cord-285262-690kpupt	250	5	-	-	JJ
cord-285262-690kpupt	250	6	proliferative	proliferative	JJ
cord-285262-690kpupt	250	7	signal	signal	NN
cord-285262-690kpupt	250	8	is	be	VBZ
cord-285262-690kpupt	250	9	blocked	block	VBN
cord-285262-690kpupt	250	10	,	,	,
cord-285262-690kpupt	250	11	the	the	DT
cord-285262-690kpupt	250	12	FADD	FADD	NNP
cord-285262-690kpupt	250	13	containing	contain	VBG
cord-285262-690kpupt	250	14	apoptotic	apoptotic	JJ
cord-285262-690kpupt	250	15	signal	signal	NN
cord-285262-690kpupt	250	16	takes	take	VBZ
cord-285262-690kpupt	250	17	over	over	RP
cord-285262-690kpupt	250	18	,	,	,
cord-285262-690kpupt	250	19	leading	lead	VBG
cord-285262-690kpupt	250	20	to	to	IN
cord-285262-690kpupt	250	21	caspase-8	caspase-8	NNP
cord-285262-690kpupt	250	22	activation	activation	NN
cord-285262-690kpupt	250	23	.	.	.
cord-285262-690kpupt	251	1	Surprisingly	surprisingly	RB
cord-285262-690kpupt	251	2	,	,	,
cord-285262-690kpupt	251	3	the	the	DT
cord-285262-690kpupt	251	4	inhibition	inhibition	NN
cord-285262-690kpupt	251	5	of	of	IN
cord-285262-690kpupt	251	6	the	the	DT
cord-285262-690kpupt	251	7	TNFR	TNFR	NNP
cord-285262-690kpupt	251	8	induced	induce	VBN
cord-285262-690kpupt	251	9	apoptosis	apoptosis	NN
cord-285262-690kpupt	251	10	by	by	IN
cord-285262-690kpupt	251	11	caspase	caspase	NN
cord-285262-690kpupt	251	12	inhibitors	inhibitor	NNS
cord-285262-690kpupt	251	13	results	result	VBZ
cord-285262-690kpupt	251	14	in	in	IN
cord-285262-690kpupt	251	15	a	a	DT
cord-285262-690kpupt	251	16	necrotic	necrotic	JJ
cord-285262-690kpupt	251	17	-	-	HYPH
cord-285262-690kpupt	251	18	like	like	JJ
cord-285262-690kpupt	251	19	cell	cell	NN
cord-285262-690kpupt	251	20	demise	demise	NN
cord-285262-690kpupt	251	21	.	.	.
cord-285262-690kpupt	252	1	This	this	DT
cord-285262-690kpupt	252	2	programmed	program	VBD
cord-285262-690kpupt	252	3	necrotic	necrotic	JJ
cord-285262-690kpupt	252	4	cell	cell	NN
cord-285262-690kpupt	252	5	death	death	NN
cord-285262-690kpupt	252	6	,	,	,
cord-285262-690kpupt	252	7	also	also	RB
cord-285262-690kpupt	252	8	termed	term	VBN
cord-285262-690kpupt	252	9	necroptosis	necroptosis	NN
cord-285262-690kpupt	252	10	can	can	MD
cord-285262-690kpupt	252	11	be	be	VB
cord-285262-690kpupt	252	12	inhibited	inhibit	VBN
cord-285262-690kpupt	252	13	by	by	IN
cord-285262-690kpupt	252	14	RIPK1	ripk1	JJ
cord-285262-690kpupt	252	15	inhibitor	inhibitor	NN
cord-285262-690kpupt	252	16	necrostatin-1	necrostatin-1	NNP
cord-285262-690kpupt	253	1	(	(	-LRB-
cord-285262-690kpupt	253	2	Xie	Xie	NNP
cord-285262-690kpupt	253	3	et	et	FW
cord-285262-690kpupt	253	4	al	al	NNP
cord-285262-690kpupt	253	5	.	.	NNP
cord-285262-690kpupt	253	6	,	,	,
cord-285262-690kpupt	253	7	2013	2013	CD
cord-285262-690kpupt	253	8	)	)	-RRB-
cord-285262-690kpupt	253	9	.	.	.
cord-285262-690kpupt	254	1	It	-PRON-	PRP
cord-285262-690kpupt	254	2	is	be	VBZ
cord-285262-690kpupt	254	3	also	also	RB
cord-285262-690kpupt	254	4	acknowledged	acknowledge	VBN
cord-285262-690kpupt	254	5	that	that	IN
cord-285262-690kpupt	254	6	the	the	DT
cord-285262-690kpupt	254	7	proteolytic	proteolytic	JJ
cord-285262-690kpupt	254	8	activity	activity	NN
cord-285262-690kpupt	254	9	of	of	IN
cord-285262-690kpupt	254	10	caspase-8	caspase-8	NNP
cord-285262-690kpupt	254	11	acts	act	NNS
cord-285262-690kpupt	254	12	against	against	IN
cord-285262-690kpupt	254	13	the	the	DT
cord-285262-690kpupt	254	14	necroptotic	necroptotic	JJ
cord-285262-690kpupt	254	15	activity	activity	NN
cord-285262-690kpupt	254	16	of	of	IN
cord-285262-690kpupt	254	17	three	three	CD
cord-285262-690kpupt	254	18	key	key	JJ
cord-285262-690kpupt	254	19	components	component	NNS
cord-285262-690kpupt	254	20	of	of	IN
cord-285262-690kpupt	254	21	the	the	DT
cord-285262-690kpupt	254	22	pathway	pathway	NN
cord-285262-690kpupt	254	23	:	:	:
cord-285262-690kpupt	254	24	RIPK1	RIPK1	NNP
cord-285262-690kpupt	254	25	,	,	,
cord-285262-690kpupt	254	26	RIPK3	ripk3	NN
cord-285262-690kpupt	254	27	and	and	CC
cord-285262-690kpupt	254	28	cylindromatosis	cylindromatosis	NN
cord-285262-690kpupt	254	29	(	(	-LRB-
cord-285262-690kpupt	254	30	CYLD	CYLD	NNP
cord-285262-690kpupt	254	31	)	)	-RRB-
cord-285262-690kpupt	254	32	(	(	-LRB-
cord-285262-690kpupt	254	33	O'Donnell	O'Donnell	NNP
cord-285262-690kpupt	254	34	et	et	NNP
cord-285262-690kpupt	254	35	al	al	NNP
cord-285262-690kpupt	254	36	.	.	.
cord-285262-690kpupt	255	1	,	,	,
cord-285262-690kpupt	255	2	2011	2011	CD
cord-285262-690kpupt	255	3	;	;	:
cord-285262-690kpupt	255	4	Tenev	Tenev	NNP
cord-285262-690kpupt	255	5	et	et	NNP
cord-285262-690kpupt	255	6	al	al	NNP
cord-285262-690kpupt	255	7	.	.	NNP
cord-285262-690kpupt	255	8	,	,	,
cord-285262-690kpupt	255	9	2011	2011	CD
cord-285262-690kpupt	255	10	)	)	-RRB-
cord-285262-690kpupt	255	11	,	,	,
cord-285262-690kpupt	255	12	hence	hence	RB
cord-285262-690kpupt	255	13	inhibition	inhibition	NN
cord-285262-690kpupt	255	14	of	of	IN
cord-285262-690kpupt	255	15	caspase-8	caspase-8	JJ
cord-285262-690kpupt	255	16	activity	activity	NN
cord-285262-690kpupt	255	17	is	be	VBZ
cord-285262-690kpupt	255	18	a	a	DT
cord-285262-690kpupt	255	19	prerequisite	prerequisite	NN
cord-285262-690kpupt	255	20	for	for	IN
cord-285262-690kpupt	255	21	the	the	DT
cord-285262-690kpupt	255	22	induction	induction	NN
cord-285262-690kpupt	255	23	of	of	IN
cord-285262-690kpupt	255	24	the	the	DT
cord-285262-690kpupt	255	25	TNFR1	TNFR1	NNP
cord-285262-690kpupt	255	26	driven	drive	VBN
cord-285262-690kpupt	255	27	necroptosis	necroptosis	NNP
cord-285262-690kpupt	255	28	(	(	-LRB-
cord-285262-690kpupt	255	29	Fig	Fig	NNP
cord-285262-690kpupt	255	30	.	.	NNP
cord-285262-690kpupt	255	31	2	2	CD
cord-285262-690kpupt	255	32	)	)	-RRB-
cord-285262-690kpupt	255	33	.	.	.
cord-285262-690kpupt	256	1	Once	once	IN
cord-285262-690kpupt	256	2	caspase-8	caspase-8	JJ
cord-285262-690kpupt	256	3	activity	activity	NN
cord-285262-690kpupt	256	4	is	be	VBZ
cord-285262-690kpupt	256	5	blocked	block	VBN
cord-285262-690kpupt	256	6	,	,	,
cord-285262-690kpupt	256	7	RIPK1	RIPK1	NNP
cord-285262-690kpupt	256	8	is	be	VBZ
cord-285262-690kpupt	256	9	enabled	enable	VBN
cord-285262-690kpupt	256	10	to	to	TO
cord-285262-690kpupt	256	11	recruit	recruit	VB
cord-285262-690kpupt	256	12	RIPK3	ripk3	NN
cord-285262-690kpupt	256	13	.	.	.
cord-285262-690kpupt	257	1	Consequently	consequently	RB
cord-285262-690kpupt	257	2	,	,	,
cord-285262-690kpupt	257	3	RIPK3	ripk3	NN
cord-285262-690kpupt	257	4	activation	activation	NN
cord-285262-690kpupt	257	5	can	can	MD
cord-285262-690kpupt	257	6	lead	lead	VB
cord-285262-690kpupt	257	7	to	to	IN
cord-285262-690kpupt	257	8	the	the	DT
cord-285262-690kpupt	257	9	phosphorylation	phosphorylation	NN
cord-285262-690kpupt	257	10	of	of	IN
cord-285262-690kpupt	257	11	the	the	DT
cord-285262-690kpupt	257	12	necroptotic	necroptotic	JJ
cord-285262-690kpupt	257	13	effector	effector	NN
cord-285262-690kpupt	257	14	mixed	mixed	JJ
cord-285262-690kpupt	257	15	lineage	lineage	NN
cord-285262-690kpupt	257	16	kinase	kinase	NN
cord-285262-690kpupt	257	17	-	-	HYPH
cord-285262-690kpupt	257	18	like	like	JJ
cord-285262-690kpupt	257	19	protein	protein	NN
cord-285262-690kpupt	257	20	(	(	-LRB-
cord-285262-690kpupt	257	21	MLKL	MLKL	NNP
cord-285262-690kpupt	257	22	)	)	-RRB-
cord-285262-690kpupt	258	1	(	(	-LRB-
cord-285262-690kpupt	258	2	Fig	Fig	NNP
cord-285262-690kpupt	258	3	.	.	.
cord-285262-690kpupt	259	1	2	2	LS
cord-285262-690kpupt	259	2	)	)	-RRB-
cord-285262-690kpupt	259	3	(	(	-LRB-
cord-285262-690kpupt	259	4	Sun	Sun	NNP
cord-285262-690kpupt	259	5	et	et	FW
cord-285262-690kpupt	259	6	al	al	NNP
cord-285262-690kpupt	259	7	.	.	NNP
cord-285262-690kpupt	259	8	,	,	,
cord-285262-690kpupt	259	9	2012	2012	CD
cord-285262-690kpupt	259	10	)	)	-RRB-
cord-285262-690kpupt	259	11	.	.	.
cord-285262-690kpupt	260	1	Upon	upon	IN
cord-285262-690kpupt	260	2	the	the	DT
cord-285262-690kpupt	260	3	phosphorylation	phosphorylation	NN
cord-285262-690kpupt	260	4	driven	drive	VBN
cord-285262-690kpupt	260	5	conformational	conformational	JJ
cord-285262-690kpupt	260	6	changes	change	NNS
cord-285262-690kpupt	260	7	,	,	,
cord-285262-690kpupt	260	8	MLKL	MLKL	NNP
cord-285262-690kpupt	260	9	oligomerizes	oligomerize	NNS
cord-285262-690kpupt	260	10	and	and	CC
cord-285262-690kpupt	260	11	forms	form	VBZ
cord-285262-690kpupt	260	12	pores	pore	NNS
cord-285262-690kpupt	260	13	throughout	throughout	IN
cord-285262-690kpupt	260	14	the	the	DT
cord-285262-690kpupt	260	15	cytoplasm	cytoplasm	NN
cord-285262-690kpupt	260	16	membrane	membrane	NN
cord-285262-690kpupt	260	17	,	,	,
cord-285262-690kpupt	260	18	resulting	result	VBG
cord-285262-690kpupt	260	19	in	in	IN
cord-285262-690kpupt	260	20	membrane	membrane	NN
cord-285262-690kpupt	260	21	integrity	integrity	NN
cord-285262-690kpupt	260	22	loss	loss	NN
cord-285262-690kpupt	260	23	.	.	.
cord-285262-690kpupt	261	1	In	in	IN
cord-285262-690kpupt	261	2	the	the	DT
cord-285262-690kpupt	261	3	past	past	JJ
cord-285262-690kpupt	261	4	decade	decade	NN
cord-285262-690kpupt	261	5	,	,	,
cord-285262-690kpupt	261	6	it	-PRON-	PRP
cord-285262-690kpupt	261	7	became	become	VBD
cord-285262-690kpupt	261	8	clear	clear	JJ
cord-285262-690kpupt	261	9	that	that	IN
cord-285262-690kpupt	261	10	RIPK1	RIPK1	NNP
cord-285262-690kpupt	261	11	is	be	VBZ
cord-285262-690kpupt	261	12	a	a	DT
cord-285262-690kpupt	261	13	multifaceted	multifaceted	JJ
cord-285262-690kpupt	261	14	scaffold	scaffold	NN
cord-285262-690kpupt	261	15	protein	protein	NN
cord-285262-690kpupt	261	16	.	.	.
cord-285262-690kpupt	262	1	If	if	IN
cord-285262-690kpupt	262	2	ubiquitinated	ubiquitinated	JJ
cord-285262-690kpupt	262	3	,	,	,
cord-285262-690kpupt	262	4	RIPK1	RIPK1	NNP
cord-285262-690kpupt	262	5	inhibits	inhibit	VBZ
cord-285262-690kpupt	262	6	the	the	DT
cord-285262-690kpupt	262	7	caspase-8	caspase-8	NNP
cord-285262-690kpupt	262	8	driven	drive	VBN
cord-285262-690kpupt	262	9	apoptosis	apoptosis	NN
cord-285262-690kpupt	262	10	and	and	CC
cord-285262-690kpupt	262	11	the	the	DT
cord-285262-690kpupt	262	12	RIPK3	RIPK3	NNS
cord-285262-690kpupt	262	13	/	/	SYM
cord-285262-690kpupt	262	14	MLKL	MLKL	NNP
cord-285262-690kpupt	262	15	dependent	dependent	JJ
cord-285262-690kpupt	262	16	necroptosis	necroptosis	NN
cord-285262-690kpupt	262	17	.	.	.
cord-285262-690kpupt	263	1	However	however	RB
cord-285262-690kpupt	263	2	,	,	,
cord-285262-690kpupt	263	3	as	as	IN
cord-285262-690kpupt	263	4	a	a	DT
cord-285262-690kpupt	263	5	deubiquitinated	deubiquitinated	JJ
cord-285262-690kpupt	263	6	protein	protein	NN
cord-285262-690kpupt	263	7	,	,	,
cord-285262-690kpupt	263	8	RIPK1	RIPK1	NNP
cord-285262-690kpupt	263	9	can	can	MD
cord-285262-690kpupt	263	10	promote	promote	VB
cord-285262-690kpupt	263	11	the	the	DT
cord-285262-690kpupt	263	12	stimulation	stimulation	NN
cord-285262-690kpupt	263	13	of	of	IN
cord-285262-690kpupt	263	14	both	both	DT
cord-285262-690kpupt	263	15	cell	cell	NN
cord-285262-690kpupt	263	16	death	death	NN
cord-285262-690kpupt	263	17	signaling	signal	VBG
cord-285262-690kpupt	263	18	pathways	pathway	NNS
cord-285262-690kpupt	263	19	(	(	-LRB-
cord-285262-690kpupt	263	20	Varfolomeev	Varfolomeev	NNP
cord-285262-690kpupt	263	21	and	and	CC
cord-285262-690kpupt	263	22	Vucic	Vucic	NNP
cord-285262-690kpupt	263	23	,	,	,
cord-285262-690kpupt	263	24	2018	2018	CD
cord-285262-690kpupt	263	25	)	)	-RRB-
cord-285262-690kpupt	263	26	.	.	.
cord-285262-690kpupt	264	1	Apart	apart	RB
cord-285262-690kpupt	264	2	from	from	IN
cord-285262-690kpupt	264	3	the	the	DT
cord-285262-690kpupt	264	4	decisive	decisive	JJ
cord-285262-690kpupt	264	5	role	role	NN
cord-285262-690kpupt	264	6	of	of	IN
cord-285262-690kpupt	264	7	ubiquitination	ubiquitination	NN
cord-285262-690kpupt	264	8	,	,	,
cord-285262-690kpupt	264	9	phosphorylation	phosphorylation	NN
cord-285262-690kpupt	264	10	at	at	IN
cord-285262-690kpupt	264	11	Ser89	Ser89	NNP
cord-285262-690kpupt	264	12	by	by	IN
cord-285262-690kpupt	264	13	protein	protein	NN
cord-285262-690kpupt	264	14	kinase	kinase	NNP
cord-285262-690kpupt	264	15	A	A	NNP
cord-285262-690kpupt	264	16	,	,	,
cord-285262-690kpupt	264	17	C	C	NNP
cord-285262-690kpupt	264	18	,	,	,
cord-285262-690kpupt	264	19	and	and	CC
cord-285262-690kpupt	264	20	phosphorylation	phosphorylation	NN
cord-285262-690kpupt	264	21	at	at	IN
cord-285262-690kpupt	264	22	several	several	JJ
cord-285262-690kpupt	264	23	sites	site	NNS
cord-285262-690kpupt	264	24	by	by	IN
cord-285262-690kpupt	264	25	IKKs	ikk	NNS
cord-285262-690kpupt	264	26	have	have	VBP
cord-285262-690kpupt	264	27	been	be	VBN
cord-285262-690kpupt	264	28	found	find	VBN
cord-285262-690kpupt	264	29	to	to	TO
cord-285262-690kpupt	264	30	be	be	VB
cord-285262-690kpupt	264	31	important	important	JJ
cord-285262-690kpupt	264	32	to	to	TO
cord-285262-690kpupt	264	33	attenuate	attenuate	VB
cord-285262-690kpupt	264	34	the	the	DT
cord-285262-690kpupt	264	35	cytotoxic	cytotoxic	JJ
cord-285262-690kpupt	264	36	potential	potential	NN
cord-285262-690kpupt	264	37	of	of	IN
cord-285262-690kpupt	264	38	this	this	DT
cord-285262-690kpupt	264	39	signaling	signal	VBG
cord-285262-690kpupt	264	40	protein	protein	NN
cord-285262-690kpupt	264	41	(	(	-LRB-
cord-285262-690kpupt	264	42	Dondelinger	Dondelinger	NNP
cord-285262-690kpupt	264	43	et	et	NNP
cord-285262-690kpupt	264	44	al	al	NNP
cord-285262-690kpupt	264	45	.	.	NNP
cord-285262-690kpupt	264	46	,	,	,
cord-285262-690kpupt	264	47	2019	2019	CD
cord-285262-690kpupt	264	48	;	;	:
cord-285262-690kpupt	264	49	McQuade	McQuade	NNP
cord-285262-690kpupt	264	50	et	et	NNP
cord-285262-690kpupt	264	51	al	al	NNP
cord-285262-690kpupt	264	52	.	.	NNP
cord-285262-690kpupt	264	53	,	,	,
cord-285262-690kpupt	264	54	2013	2013	CD
cord-285262-690kpupt	264	55	)	)	-RRB-
cord-285262-690kpupt	264	56	.	.	.
cord-285262-690kpupt	265	1	The	the	DT
cord-285262-690kpupt	265	2	current	current	JJ
cord-285262-690kpupt	265	3	observations	observation	NNS
cord-285262-690kpupt	265	4	indicate	indicate	VBP
cord-285262-690kpupt	265	5	that	that	IN
cord-285262-690kpupt	265	6	the	the	DT
cord-285262-690kpupt	265	7	majority	majority	NN
cord-285262-690kpupt	265	8	of	of	IN
cord-285262-690kpupt	265	9	the	the	DT
cord-285262-690kpupt	265	10	human	human	JJ
cord-285262-690kpupt	265	11	pathogen	pathogen	NN
cord-285262-690kpupt	265	12	viruses	virus	NNS
cord-285262-690kpupt	265	13	developed	develop	VBD
cord-285262-690kpupt	265	14	strategies	strategy	NNS
cord-285262-690kpupt	265	15	to	to	TO
cord-285262-690kpupt	265	16	avoid	avoid	VB
cord-285262-690kpupt	265	17	the	the	DT
cord-285262-690kpupt	265	18	necroptotic	necroptotic	JJ
cord-285262-690kpupt	265	19	signaling	signaling	NN
cord-285262-690kpupt	265	20	of	of	IN
cord-285262-690kpupt	265	21	the	the	DT
cord-285262-690kpupt	265	22	host	host	NN
cord-285262-690kpupt	265	23	.	.	.
cord-285262-690kpupt	266	1	Conversely	conversely	RB
cord-285262-690kpupt	266	2	,	,	,
cord-285262-690kpupt	266	3	human	human	JJ
cord-285262-690kpupt	266	4	immunodeficiency	immunodeficiency	NN
cord-285262-690kpupt	266	5	virus	virus	NN
cord-285262-690kpupt	266	6	type	type	NN
cord-285262-690kpupt	266	7	1	1	CD
cord-285262-690kpupt	266	8	(	(	-LRB-
cord-285262-690kpupt	266	9	HIV-1	HIV-1	NNP
cord-285262-690kpupt	266	10	)	)	-RRB-
cord-285262-690kpupt	266	11	induces	induce	VBZ
cord-285262-690kpupt	266	12	TNFα	TNFα	NNP
cord-285262-690kpupt	266	13	dependent	dependent	JJ
cord-285262-690kpupt	266	14	necroptotic	necroptotic	JJ
cord-285262-690kpupt	266	15	cell	cell	NN
cord-285262-690kpupt	266	16	death	death	NN
cord-285262-690kpupt	266	17	in	in	IN
cord-285262-690kpupt	266	18	CD4	CD4	NNP
cord-285262-690kpupt	266	19	+	+	CC
cord-285262-690kpupt	266	20	T	t	NN
cord-285262-690kpupt	266	21	lymphocytes	lymphocyte	NNS
cord-285262-690kpupt	266	22	,	,	,
cord-285262-690kpupt	266	23	which	which	WDT
cord-285262-690kpupt	266	24	can	can	MD
cord-285262-690kpupt	266	25	be	be	VB
cord-285262-690kpupt	266	26	inhibited	inhibit	VBN
cord-285262-690kpupt	266	27	by	by	IN
cord-285262-690kpupt	266	28	necrostatin-1	necrostatin-1	NNP
cord-285262-690kpupt	266	29	.	.	.
cord-285262-690kpupt	267	1	Unlike	unlike	IN
cord-285262-690kpupt	267	2	apoptosis	apoptosis	NN
cord-285262-690kpupt	267	3	,	,	,
cord-285262-690kpupt	267	4	this	this	DT
cord-285262-690kpupt	267	5	cell	cell	NN
cord-285262-690kpupt	267	6	death	death	NN
cord-285262-690kpupt	267	7	occurs	occur	VBZ
cord-285262-690kpupt	267	8	in	in	IN
cord-285262-690kpupt	267	9	infected	infected	JJ
cord-285262-690kpupt	267	10	cells	cell	NNS
cord-285262-690kpupt	267	11	and	and	CC
cord-285262-690kpupt	267	12	spares	spare	VBZ
cord-285262-690kpupt	267	13	the	the	DT
cord-285262-690kpupt	267	14	bystander	bystander	NN
cord-285262-690kpupt	267	15	cells	cell	NNS
cord-285262-690kpupt	267	16	(	(	-LRB-
cord-285262-690kpupt	267	17	Pan	Pan	NNP
cord-285262-690kpupt	267	18	et	et	FW
cord-285262-690kpupt	267	19	al	al	NNP
cord-285262-690kpupt	267	20	.	.	NNP
cord-285262-690kpupt	267	21	,	,	,
cord-285262-690kpupt	267	22	2014	2014	CD
cord-285262-690kpupt	267	23	)	)	-RRB-
cord-285262-690kpupt	267	24	.	.	.
cord-285262-690kpupt	268	1	Nevertheless	nevertheless	RB
cord-285262-690kpupt	268	2	,	,	,
cord-285262-690kpupt	268	3	the	the	DT
cord-285262-690kpupt	268	4	HIV	HIV	NNP
cord-285262-690kpupt	268	5	triggered	trigger	VBD
cord-285262-690kpupt	268	6	necroptosis	necroptosis	NN
cord-285262-690kpupt	268	7	is	be	VBZ
cord-285262-690kpupt	268	8	considered	consider	VBN
cord-285262-690kpupt	268	9	detrimental	detrimental	JJ
cord-285262-690kpupt	268	10	for	for	IN
cord-285262-690kpupt	268	11	the	the	DT
cord-285262-690kpupt	268	12	host	host	NN
cord-285262-690kpupt	268	13	by	by	IN
cord-285262-690kpupt	268	14	targeting	target	VBG
cord-285262-690kpupt	268	15	the	the	DT
cord-285262-690kpupt	268	16	defensive	defensive	JJ
cord-285262-690kpupt	268	17	mechanisms	mechanism	NNS
cord-285262-690kpupt	268	18	of	of	IN
cord-285262-690kpupt	268	19	the	the	DT
cord-285262-690kpupt	268	20	immune	immune	JJ
cord-285262-690kpupt	268	21	system	system	NN
cord-285262-690kpupt	268	22	.	.	.
cord-285262-690kpupt	269	1	Another	another	DT
cord-285262-690kpupt	269	2	example	example	NN
cord-285262-690kpupt	269	3	,	,	,
cord-285262-690kpupt	269	4	where	where	WRB
cord-285262-690kpupt	269	5	necroptosis	necroptosis	NNP
cord-285262-690kpupt	269	6	is	be	VBZ
cord-285262-690kpupt	269	7	triggered	trigger	VBN
cord-285262-690kpupt	269	8	by	by	IN
cord-285262-690kpupt	269	9	viruses	virus	NNS
cord-285262-690kpupt	269	10	,	,	,
cord-285262-690kpupt	269	11	takes	take	VBZ
cord-285262-690kpupt	269	12	places	place	NNS
cord-285262-690kpupt	269	13	in	in	IN
cord-285262-690kpupt	269	14	response	response	NN
cord-285262-690kpupt	269	15	to	to	IN
cord-285262-690kpupt	269	16	human	human	JJ
cord-285262-690kpupt	269	17	coronavirus	coronavirus	NN
cord-285262-690kpupt	269	18	(	(	-LRB-
cord-285262-690kpupt	269	19	HCoV	HCoV	NNP
cord-285262-690kpupt	269	20	)	)	-RRB-
cord-285262-690kpupt	269	21	infection	infection	NN
cord-285262-690kpupt	269	22	.	.	.
cord-285262-690kpupt	270	1	HCoV	HCoV	NNP
cord-285262-690kpupt	270	2	is	be	VBZ
cord-285262-690kpupt	270	3	a	a	DT
cord-285262-690kpupt	270	4	neuroinvasive	neuroinvasive	JJ
cord-285262-690kpupt	270	5	respiratory	respiratory	JJ
cord-285262-690kpupt	270	6	pathogen	pathogen	NN
cord-285262-690kpupt	270	7	,	,	,
cord-285262-690kpupt	270	8	which	which	WDT
cord-285262-690kpupt	270	9	induces	induce	VBZ
cord-285262-690kpupt	270	10	a	a	DT
cord-285262-690kpupt	270	11	cell	cell	NN
cord-285262-690kpupt	270	12	death	death	NN
cord-285262-690kpupt	270	13	pathway	pathway	NN
cord-285262-690kpupt	270	14	dependent	dependent	JJ
cord-285262-690kpupt	270	15	on	on	IN
cord-285262-690kpupt	270	16	RIPK1	RIPK1	NNP
cord-285262-690kpupt	270	17	and	and	CC
cord-285262-690kpupt	270	18	MLKL	MLKL	NNP
cord-285262-690kpupt	270	19	in	in	IN
cord-285262-690kpupt	270	20	human	human	JJ
cord-285262-690kpupt	270	21	neuroblastoma	neuroblastoma	NN
cord-285262-690kpupt	270	22	cells	cell	NNS
cord-285262-690kpupt	270	23	(	(	-LRB-
cord-285262-690kpupt	270	24	Meessen	Meessen	NNP
cord-285262-690kpupt	270	25	-	-	HYPH
cord-285262-690kpupt	270	26	Pinard	Pinard	NNP
cord-285262-690kpupt	270	27	et	et	NNP
cord-285262-690kpupt	270	28	al	al	NNP
cord-285262-690kpupt	270	29	.	.	NNP
cord-285262-690kpupt	270	30	,	,	,
cord-285262-690kpupt	270	31	2017	2017	CD
cord-285262-690kpupt	270	32	)	)	-RRB-
cord-285262-690kpupt	270	33	.	.	.
cord-285262-690kpupt	271	1	The	the	DT
cord-285262-690kpupt	271	2	protein	protein	NN
cord-285262-690kpupt	271	3	z	z	NN
cord-285262-690kpupt	271	4	-	-	HYPH
cord-285262-690kpupt	271	5	DNA	DNA	NNP
cord-285262-690kpupt	271	6	/	/	SYM
cord-285262-690kpupt	271	7	RNA	RNA	NNP
cord-285262-690kpupt	271	8	binding	bind	VBG
cord-285262-690kpupt	271	9	protein-1	protein-1	NNP
cord-285262-690kpupt	271	10	(	(	-LRB-
cord-285262-690kpupt	271	11	ZBP1	ZBP1	NNP
cord-285262-690kpupt	271	12	;	;	:
cord-285262-690kpupt	271	13	also	also	RB
cord-285262-690kpupt	271	14	known	know	VBN
cord-285262-690kpupt	271	15	as	as	IN
cord-285262-690kpupt	271	16	DAI	DAI	NNP
cord-285262-690kpupt	271	17	)	)	-RRB-
cord-285262-690kpupt	271	18	recognizes	recognize	VBZ
cord-285262-690kpupt	271	19	z	z	NNP
cord-285262-690kpupt	271	20	-	-	HYPH
cord-285262-690kpupt	271	21	RNA	RNA	NNP
cord-285262-690kpupt	271	22	or	or	CC
cord-285262-690kpupt	271	23	z	z	NN
cord-285262-690kpupt	271	24	-	-	HYPH
cord-285262-690kpupt	271	25	DNA	dna	NN
cord-285262-690kpupt	271	26	structures	structure	NNS
cord-285262-690kpupt	271	27	,	,	,
cord-285262-690kpupt	271	28	which	which	WDT
cord-285262-690kpupt	271	29	are	be	VBP
cord-285262-690kpupt	271	30	common	common	JJ
cord-285262-690kpupt	271	31	as	as	IN
cord-285262-690kpupt	271	32	a	a	DT
cord-285262-690kpupt	271	33	consequence	consequence	NN
cord-285262-690kpupt	271	34	of	of	IN
cord-285262-690kpupt	271	35	a	a	DT
cord-285262-690kpupt	271	36	rapid	rapid	JJ
cord-285262-690kpupt	271	37	viral	viral	JJ
cord-285262-690kpupt	271	38	RNA	RNA	NNP
cord-285262-690kpupt	271	39	and	and	CC
cord-285262-690kpupt	271	40	DNA	dna	NN
cord-285262-690kpupt	271	41	synthesis	synthesis	NN
cord-285262-690kpupt	271	42	,	,	,
cord-285262-690kpupt	271	43	but	but	CC
cord-285262-690kpupt	271	44	distinct	distinct	JJ
cord-285262-690kpupt	271	45	from	from	IN
cord-285262-690kpupt	271	46	the	the	DT
cord-285262-690kpupt	271	47	B	B	NNP
cord-285262-690kpupt	271	48	structure	structure	NN
cord-285262-690kpupt	271	49	of	of	IN
cord-285262-690kpupt	271	50	the	the	DT
cord-285262-690kpupt	271	51	eukaryotic	eukaryotic	JJ
cord-285262-690kpupt	271	52	RNA	RNA	NNP
cord-285262-690kpupt	271	53	or	or	CC
cord-285262-690kpupt	271	54	DNA	DNA	NNP
cord-285262-690kpupt	271	55	.	.	.
cord-285262-690kpupt	272	1	ZBP1	ZBP1	NNP
cord-285262-690kpupt	272	2	can	can	MD
cord-285262-690kpupt	272	3	activate	activate	VB
cord-285262-690kpupt	272	4	RIPK3	ripk3	NN
cord-285262-690kpupt	273	1	(	(	-LRB-
cord-285262-690kpupt	273	2	Upton	Upton	NNP
cord-285262-690kpupt	273	3	et	et	NNP
cord-285262-690kpupt	273	4	al	al	NNP
cord-285262-690kpupt	273	5	.	.	NNP
cord-285262-690kpupt	273	6	,	,	,
cord-285262-690kpupt	273	7	2012	2012	CD
cord-285262-690kpupt	273	8	)	)	-RRB-
cord-285262-690kpupt	273	9	,	,	,
cord-285262-690kpupt	273	10	since	since	IN
cord-285262-690kpupt	273	11	it	-PRON-	PRP
cord-285262-690kpupt	273	12	is	be	VBZ
cord-285262-690kpupt	273	13	capable	capable	JJ
cord-285262-690kpupt	273	14	to	to	TO
cord-285262-690kpupt	273	15	interact	interact	VB
cord-285262-690kpupt	273	16	the	the	DT
cord-285262-690kpupt	273	17	RIPKs	ripks	NN
cord-285262-690kpupt	273	18	via	via	IN
cord-285262-690kpupt	273	19	its	-PRON-	PRP$
cord-285262-690kpupt	273	20	RHIM	RHIM	NNP
cord-285262-690kpupt	273	21	(	(	-LRB-
cord-285262-690kpupt	273	22	Fig	Fig	NNP
cord-285262-690kpupt	273	23	.	.	NNP
cord-285262-690kpupt	273	24	2	2	CD
cord-285262-690kpupt	273	25	)	)	-RRB-
cord-285262-690kpupt	273	26	.	.	.
cord-285262-690kpupt	274	1	Intriguingly	intriguingly	RB
cord-285262-690kpupt	274	2	,	,	,
cord-285262-690kpupt	274	3	MEFs	mef	NNS
cord-285262-690kpupt	274	4	,	,	,
cord-285262-690kpupt	274	5	liver	liver	NN
cord-285262-690kpupt	274	6	cells	cell	NNS
cord-285262-690kpupt	274	7	,	,	,
cord-285262-690kpupt	274	8	lymphoid	lymphoid	JJ
cord-285262-690kpupt	274	9	cells	cell	NNS
cord-285262-690kpupt	274	10	and	and	CC
cord-285262-690kpupt	274	11	skin	skin	NN
cord-285262-690kpupt	274	12	cells	cell	NNS
cord-285262-690kpupt	274	13	isolated	isolate	VBN
cord-285262-690kpupt	274	14	from	from	IN
cord-285262-690kpupt	274	15	mice	mouse	NNS
cord-285262-690kpupt	274	16	exhibiting	exhibit	VBG
cord-285262-690kpupt	274	17	catalytically	catalytically	RB
cord-285262-690kpupt	274	18	inactive	inactive	JJ
cord-285262-690kpupt	274	19	RIPK1	RIPK1	NNS
cord-285262-690kpupt	274	20	die	die	VBP
cord-285262-690kpupt	274	21	early	early	JJ
cord-285262-690kpupt	274	22	and	and	CC
cord-285262-690kpupt	274	23	exert	exert	VB
cord-285262-690kpupt	274	24	RIPK3	ripk3	NN
cord-285262-690kpupt	274	25	auto	auto	NN
cord-285262-690kpupt	274	26	-	-	HYPH
cord-285262-690kpupt	274	27	phosphorylation	phosphorylation	NN
cord-285262-690kpupt	274	28	,	,	,
cord-285262-690kpupt	274	29	a	a	DT
cord-285262-690kpupt	274	30	hallmark	hallmark	NN
cord-285262-690kpupt	274	31	of	of	IN
cord-285262-690kpupt	274	32	the	the	DT
cord-285262-690kpupt	274	33	necroptotic	necroptotic	JJ
cord-285262-690kpupt	274	34	activation	activation	NN
cord-285262-690kpupt	274	35	,	,	,
cord-285262-690kpupt	274	36	whereas	whereas	IN
cord-285262-690kpupt	274	37	RIPK3	RIPK3	NNS
cord-285262-690kpupt	274	38	and	and	CC
cord-285262-690kpupt	274	39	MLKL	MLKL	NNP
cord-285262-690kpupt	274	40	deficient	deficient	JJ
cord-285262-690kpupt	274	41	mice	mouse	NNS
cord-285262-690kpupt	274	42	are	be	VBP
cord-285262-690kpupt	274	43	protected	protect	VBN
cord-285262-690kpupt	274	44	from	from	IN
cord-285262-690kpupt	274	45	the	the	DT
cord-285262-690kpupt	274	46	cell	cell	NN
cord-285262-690kpupt	274	47	death	death	NN
cord-285262-690kpupt	274	48	ex	ex	FW
cord-285262-690kpupt	274	49	vivo	vivo	NN
cord-285262-690kpupt	274	50	and	and	CC
cord-285262-690kpupt	274	51	in	in	IN
cord-285262-690kpupt	274	52	vivo	vivo	NNP
cord-285262-690kpupt	274	53	.	.	.
cord-285262-690kpupt	275	1	Furthermore	furthermore	RB
cord-285262-690kpupt	275	2	,	,	,
cord-285262-690kpupt	275	3	the	the	DT
cord-285262-690kpupt	275	4	ZBP1-RIPK3	zbp1-ripk3	NN
cord-285262-690kpupt	275	5	interaction	interaction	NN
cord-285262-690kpupt	275	6	can	can	MD
cord-285262-690kpupt	275	7	be	be	VB
cord-285262-690kpupt	275	8	blocked	block	VBN
cord-285262-690kpupt	275	9	in	in	IN
cord-285262-690kpupt	275	10	macrophages	macrophage	NNS
cord-285262-690kpupt	275	11	from	from	IN
cord-285262-690kpupt	275	12	wild	wild	JJ
cord-285262-690kpupt	275	13	type	type	NN
cord-285262-690kpupt	275	14	mice	mouse	NNS
cord-285262-690kpupt	275	15	,	,	,
cord-285262-690kpupt	275	16	whereas	whereas	IN
cord-285262-690kpupt	275	17	the	the	DT
cord-285262-690kpupt	275	18	interaction	interaction	NN
cord-285262-690kpupt	275	19	takes	take	VBZ
cord-285262-690kpupt	275	20	place	place	NN
cord-285262-690kpupt	275	21	in	in	IN
cord-285262-690kpupt	275	22	mouse	mouse	NN
cord-285262-690kpupt	275	23	macrophages	macrophage	NNS
cord-285262-690kpupt	275	24	that	that	WDT
cord-285262-690kpupt	275	25	express	express	VBP
cord-285262-690kpupt	275	26	a	a	DT
cord-285262-690kpupt	275	27	RHIM	RHIM	NNP
cord-285262-690kpupt	275	28	deficient	deficient	JJ
cord-285262-690kpupt	275	29	RIPK1	ripk1	NN
cord-285262-690kpupt	275	30	.	.	.
cord-285262-690kpupt	276	1	These	these	DT
cord-285262-690kpupt	276	2	results	result	NNS
cord-285262-690kpupt	276	3	indicate	indicate	VBP
cord-285262-690kpupt	276	4	that	that	IN
cord-285262-690kpupt	276	5	RIPK1	ripk1	JJ
cord-285262-690kpupt	276	6	acts	act	VBZ
cord-285262-690kpupt	276	7	as	as	IN
cord-285262-690kpupt	276	8	a	a	DT
cord-285262-690kpupt	276	9	negative	negative	JJ
cord-285262-690kpupt	276	10	regulator	regulator	NN
cord-285262-690kpupt	276	11	of	of	IN
cord-285262-690kpupt	276	12	ZPB1-RIPK3	zpb1-ripk3	NN
cord-285262-690kpupt	276	13	interaction	interaction	NN
cord-285262-690kpupt	276	14	during	during	IN
cord-285262-690kpupt	276	15	development	development	NN
cord-285262-690kpupt	276	16	in	in	IN
cord-285262-690kpupt	276	17	order	order	NN
cord-285262-690kpupt	276	18	to	to	TO
cord-285262-690kpupt	276	19	prevent	prevent	VB
cord-285262-690kpupt	276	20	premature	premature	JJ
cord-285262-690kpupt	276	21	necroptosis	necroptosis	NN
cord-285262-690kpupt	276	22	(	(	-LRB-
cord-285262-690kpupt	276	23	Newton	Newton	NNP
cord-285262-690kpupt	276	24	et	et	NNP
cord-285262-690kpupt	276	25	al	al	NNP
cord-285262-690kpupt	276	26	.	.	NNP
cord-285262-690kpupt	276	27	,	,	,
cord-285262-690kpupt	276	28	2016	2016	CD
cord-285262-690kpupt	276	29	)	)	-RRB-
cord-285262-690kpupt	276	30	.	.	.
cord-285262-690kpupt	277	1	To	to	IN
cord-285262-690kpupt	277	2	date	date	NN
cord-285262-690kpupt	277	3	,	,	,
cord-285262-690kpupt	277	4	IAV	IAV	NNP
cord-285262-690kpupt	277	5	infection	infection	NN
cord-285262-690kpupt	277	6	is	be	VBZ
cord-285262-690kpupt	277	7	the	the	DT
cord-285262-690kpupt	277	8	only	only	JJ
cord-285262-690kpupt	277	9	example	example	NN
cord-285262-690kpupt	277	10	,	,	,
cord-285262-690kpupt	277	11	where	where	WRB
cord-285262-690kpupt	277	12	ZBP1	ZBP1	NNP
cord-285262-690kpupt	277	13	dependent	dependent	JJ
cord-285262-690kpupt	277	14	necroptosis	necroptosis	NN
cord-285262-690kpupt	277	15	occurs	occur	VBZ
cord-285262-690kpupt	277	16	in	in	IN
cord-285262-690kpupt	277	17	response	response	NN
cord-285262-690kpupt	277	18	to	to	IN
cord-285262-690kpupt	277	19	viral	viral	JJ
cord-285262-690kpupt	277	20	infections	infection	NNS
cord-285262-690kpupt	277	21	employing	employ	VBG
cord-285262-690kpupt	277	22	non	non	JJ
cord-285262-690kpupt	277	23	-	-	JJ
cord-285262-690kpupt	277	24	engineered	engineered	JJ
cord-285262-690kpupt	277	25	(	(	-LRB-
cord-285262-690kpupt	277	26	wild	wild	JJ
cord-285262-690kpupt	277	27	type	type	NN
cord-285262-690kpupt	277	28	)	)	-RRB-
cord-285262-690kpupt	277	29	virus	virus	NN
cord-285262-690kpupt	277	30	strains	strain	NNS
cord-285262-690kpupt	277	31	.	.	.
cord-285262-690kpupt	278	1	IAV	IAV	NNP
cord-285262-690kpupt	278	2	induces	induce	VBZ
cord-285262-690kpupt	278	3	RIPK3	RIPK3	NNS
cord-285262-690kpupt	278	4	and	and	CC
cord-285262-690kpupt	278	5	MLKL	MLKL	NNP
cord-285262-690kpupt	278	6	dependent	dependent	JJ
cord-285262-690kpupt	278	7	,	,	,
cord-285262-690kpupt	278	8	but	but	CC
cord-285262-690kpupt	278	9	TNFα	TNFα	NNS
cord-285262-690kpupt	278	10	and	and	CC
cord-285262-690kpupt	278	11	TLR	TLR	NNP
cord-285262-690kpupt	278	12	independent	independent	JJ
cord-285262-690kpupt	278	13	necroptosis	necroptosis	NN
cord-285262-690kpupt	278	14	.	.	.
cord-285262-690kpupt	279	1	This	this	DT
cord-285262-690kpupt	279	2	pathway	pathway	NN
cord-285262-690kpupt	279	3	is	be	VBZ
cord-285262-690kpupt	279	4	mediated	mediate	VBN
cord-285262-690kpupt	279	5	through	through	IN
cord-285262-690kpupt	279	6	ZBP1	ZBP1	NNP
cord-285262-690kpupt	279	7	by	by	IN
cord-285262-690kpupt	279	8	sensing	sense	VBG
cord-285262-690kpupt	279	9	viral	viral	JJ
cord-285262-690kpupt	279	10	genomic	genomic	JJ
cord-285262-690kpupt	279	11	RNA	RNA	NNP
cord-285262-690kpupt	279	12	segments	segment	NNS
cord-285262-690kpupt	279	13	.	.	.
cord-285262-690kpupt	280	1	A	a	DT
cord-285262-690kpupt	280	2	recent	recent	JJ
cord-285262-690kpupt	280	3	study	study	NN
cord-285262-690kpupt	280	4	(	(	-LRB-
cord-285262-690kpupt	280	5	Wang	Wang	NNP
cord-285262-690kpupt	280	6	et	et	NNP
cord-285262-690kpupt	280	7	al	al	NNP
cord-285262-690kpupt	280	8	.	.	NNP
cord-285262-690kpupt	280	9	,	,	,
cord-285262-690kpupt	280	10	2019b	2019b	CD
cord-285262-690kpupt	280	11	)	)	-RRB-
cord-285262-690kpupt	280	12	performed	perform	VBN
cord-285262-690kpupt	280	13	in	in	IN
cord-285262-690kpupt	280	14	mice	mouse	NNS
cord-285262-690kpupt	280	15	further	further	RB
cord-285262-690kpupt	280	16	confirms	confirm	VBZ
cord-285262-690kpupt	280	17	the	the	DT
cord-285262-690kpupt	280	18	role	role	NN
cord-285262-690kpupt	280	19	of	of	IN
cord-285262-690kpupt	280	20	ZBP-1	ZBP-1	NNP
cord-285262-690kpupt	280	21	as	as	IN
cord-285262-690kpupt	280	22	the	the	DT
cord-285262-690kpupt	280	23	key	key	JJ
cord-285262-690kpupt	280	24	necroptosis	necroptosis	NN
cord-285262-690kpupt	280	25	modulator	modulator	NN
cord-285262-690kpupt	280	26	protein	protein	NN
cord-285262-690kpupt	280	27	in	in	IN
cord-285262-690kpupt	280	28	response	response	NN
cord-285262-690kpupt	280	29	to	to	IN
cord-285262-690kpupt	280	30	IAV	IAV	NNP
cord-285262-690kpupt	280	31	infection	infection	NN
cord-285262-690kpupt	280	32	in	in	IN
cord-285262-690kpupt	280	33	vivo	vivo	NN
cord-285262-690kpupt	280	34	.	.	.
cord-285262-690kpupt	281	1	Aside	aside	RB
cord-285262-690kpupt	281	2	from	from	IN
cord-285262-690kpupt	281	3	the	the	DT
cord-285262-690kpupt	281	4	necroptosis	necroptosis	NN
cord-285262-690kpupt	281	5	stimulatory	stimulatory	JJ
cord-285262-690kpupt	281	6	effects	effect	NNS
cord-285262-690kpupt	281	7	of	of	IN
cord-285262-690kpupt	281	8	the	the	DT
cord-285262-690kpupt	281	9	viral	viral	JJ
cord-285262-690kpupt	281	10	RNA	RNA	NNP
cord-285262-690kpupt	281	11	fragments	fragment	NNS
cord-285262-690kpupt	281	12	,	,	,
cord-285262-690kpupt	281	13	the	the	DT
cord-285262-690kpupt	281	14	NS1	ns1	NN
cord-285262-690kpupt	281	15	protein	protein	NN
cord-285262-690kpupt	281	16	of	of	IN
cord-285262-690kpupt	281	17	the	the	DT
cord-285262-690kpupt	281	18	IAV	IAV	NNP
cord-285262-690kpupt	281	19	is	be	VBZ
cord-285262-690kpupt	281	20	suggested	suggest	VBN
cord-285262-690kpupt	281	21	as	as	IN
cord-285262-690kpupt	281	22	a	a	DT
cord-285262-690kpupt	281	23	direct	direct	JJ
cord-285262-690kpupt	281	24	interactor	interactor	NN
cord-285262-690kpupt	281	25	of	of	IN
cord-285262-690kpupt	281	26	MLKL	MLKL	NNP
cord-285262-690kpupt	282	1	(	(	-LRB-
cord-285262-690kpupt	282	2	Gaba	Gaba	NNP
cord-285262-690kpupt	282	3	et	et	FW
cord-285262-690kpupt	282	4	al	al	NNP
cord-285262-690kpupt	282	5	.	.	NNP
cord-285262-690kpupt	282	6	,	,	,
cord-285262-690kpupt	282	7	2019	2019	CD
cord-285262-690kpupt	282	8	)	)	-RRB-
cord-285262-690kpupt	282	9	.	.	.
cord-285262-690kpupt	283	1	Finally	finally	RB
cord-285262-690kpupt	283	2	,	,	,
cord-285262-690kpupt	283	3	the	the	DT
cord-285262-690kpupt	283	4	transcriptional	transcriptional	JJ
cord-285262-690kpupt	283	5	regulation	regulation	NN
cord-285262-690kpupt	283	6	of	of	IN
cord-285262-690kpupt	283	7	ZBP1	ZBP1	NNP
cord-285262-690kpupt	283	8	seems	seem	VBZ
cord-285262-690kpupt	283	9	to	to	TO
cord-285262-690kpupt	283	10	be	be	VB
cord-285262-690kpupt	283	11	dependent	dependent	JJ
cord-285262-690kpupt	283	12	on	on	IN
cord-285262-690kpupt	283	13	the	the	DT
cord-285262-690kpupt	283	14	interferon	interferon	NN
cord-285262-690kpupt	283	15	regulatory	regulatory	JJ
cord-285262-690kpupt	283	16	factor	factor	NN
cord-285262-690kpupt	283	17	1	1	CD
cord-285262-690kpupt	283	18	(	(	-LRB-
cord-285262-690kpupt	283	19	IRF1	IRF1	NNP
cord-285262-690kpupt	283	20	)	)	-RRB-
cord-285262-690kpupt	283	21	,	,	,
cord-285262-690kpupt	283	22	which	which	WDT
cord-285262-690kpupt	283	23	is	be	VBZ
cord-285262-690kpupt	283	24	activated	activate	VBN
cord-285262-690kpupt	283	25	in	in	IN
cord-285262-690kpupt	283	26	mouse	mouse	NN
cord-285262-690kpupt	283	27	bone	bone	NN
cord-285262-690kpupt	283	28	marrow	marrow	NN
cord-285262-690kpupt	283	29	-	-	HYPH
cord-285262-690kpupt	283	30	derived	derive	VBN
cord-285262-690kpupt	283	31	macrophages	macrophage	NNS
cord-285262-690kpupt	283	32	in	in	IN
cord-285262-690kpupt	283	33	response	response	NN
cord-285262-690kpupt	283	34	to	to	IN
cord-285262-690kpupt	283	35	IAV	IAV	NNP
cord-285262-690kpupt	283	36	infection	infection	NN
cord-285262-690kpupt	284	1	(	(	-LRB-
cord-285262-690kpupt	284	2	Kuriakose	Kuriakose	NNP
cord-285262-690kpupt	284	3	et	et	NNP
cord-285262-690kpupt	284	4	al	al	NNP
cord-285262-690kpupt	284	5	.	.	NNP
cord-285262-690kpupt	284	6	,	,	,
cord-285262-690kpupt	284	7	2018	2018	CD
cord-285262-690kpupt	284	8	)	)	-RRB-
cord-285262-690kpupt	284	9	.	.	.
cord-285262-690kpupt	285	1	Consequently	consequently	RB
cord-285262-690kpupt	285	2	,	,	,
cord-285262-690kpupt	285	3	depletion	depletion	NN
cord-285262-690kpupt	285	4	of	of	IN
cord-285262-690kpupt	285	5	IRF1	IRF1	NNP
cord-285262-690kpupt	285	6	can	can	MD
cord-285262-690kpupt	285	7	reduce	reduce	VB
cord-285262-690kpupt	285	8	the	the	DT
cord-285262-690kpupt	285	9	level	level	NN
cord-285262-690kpupt	285	10	of	of	IN
cord-285262-690kpupt	285	11	ZBP1	ZBP1	NNP
cord-285262-690kpupt	285	12	and	and	CC
cord-285262-690kpupt	285	13	diminish	diminish	VB
cord-285262-690kpupt	285	14	the	the	DT
cord-285262-690kpupt	285	15	IAV	IAV	NNP
cord-285262-690kpupt	285	16	induced	induce	VBN
cord-285262-690kpupt	285	17	necroptotic	necroptotic	JJ
cord-285262-690kpupt	285	18	features	feature	NNS
cord-285262-690kpupt	285	19	,	,	,
cord-285262-690kpupt	285	20	including	include	VBG
cord-285262-690kpupt	285	21	MLKL	MLKL	NNP
cord-285262-690kpupt	285	22	phosphorylation	phosphorylation	NN
cord-285262-690kpupt	285	23	and	and	CC
cord-285262-690kpupt	285	24	membrane	membrane	NN
cord-285262-690kpupt	285	25	integrity	integrity	NN
cord-285262-690kpupt	285	26	loss	loss	NN
cord-285262-690kpupt	285	27	.	.	.
cord-285262-690kpupt	286	1	Murine	murine	JJ
cord-285262-690kpupt	286	2	cytomegalovirus	cytomegalovirus	NN
cord-285262-690kpupt	286	3	(	(	-LRB-
cord-285262-690kpupt	286	4	MCMV	MCMV	NNP
cord-285262-690kpupt	286	5	)	)	-RRB-
cord-285262-690kpupt	286	6	lacking	lack	VBG
cord-285262-690kpupt	286	7	the	the	DT
cord-285262-690kpupt	286	8	viral	viral	JJ
cord-285262-690kpupt	286	9	M45-encoded	M45-encoded	NNP
cord-285262-690kpupt	286	10	inhibitor	inhibitor	NN
cord-285262-690kpupt	286	11	of	of	IN
cord-285262-690kpupt	286	12	RIPK	RIPK	NNP
cord-285262-690kpupt	286	13	(	(	-LRB-
cord-285262-690kpupt	286	14	vIRA	vira	NN
cord-285262-690kpupt	286	15	)	)	-RRB-
cord-285262-690kpupt	286	16	triggers	trigger	VBZ
cord-285262-690kpupt	286	17	premature	premature	JJ
cord-285262-690kpupt	286	18	cell	cell	NN
cord-285262-690kpupt	286	19	death	death	NN
cord-285262-690kpupt	286	20	in	in	IN
cord-285262-690kpupt	286	21	mice	mouse	NNS
cord-285262-690kpupt	286	22	.	.	.
cord-285262-690kpupt	287	1	Importantly	importantly	RB
cord-285262-690kpupt	287	2	,	,	,
cord-285262-690kpupt	287	3	RIPK3	ripk3	NN
cord-285262-690kpupt	287	4	knockout	knockout	NN
cord-285262-690kpupt	287	5	can	can	MD
cord-285262-690kpupt	287	6	rescue	rescue	VB
cord-285262-690kpupt	287	7	the	the	DT
cord-285262-690kpupt	287	8	premature	premature	JJ
cord-285262-690kpupt	287	9	death	death	NN
cord-285262-690kpupt	287	10	phenotype	phenotype	NN
cord-285262-690kpupt	287	11	,	,	,
cord-285262-690kpupt	287	12	indicating	indicate	VBG
cord-285262-690kpupt	287	13	that	that	IN
cord-285262-690kpupt	287	14	the	the	DT
cord-285262-690kpupt	287	15	MCMV	MCMV	NNP
cord-285262-690kpupt	287	16	infection	infection	NN
cord-285262-690kpupt	287	17	induces	induce	VBZ
cord-285262-690kpupt	287	18	a	a	DT
cord-285262-690kpupt	287	19	RIPK3	ripk3	NN
cord-285262-690kpupt	287	20	dependent	dependent	JJ
cord-285262-690kpupt	287	21	necroptotic	necroptotic	JJ
cord-285262-690kpupt	287	22	cell	cell	NN
cord-285262-690kpupt	287	23	death	death	NN
cord-285262-690kpupt	287	24	(	(	-LRB-
cord-285262-690kpupt	287	25	Upton	Upton	NNP
cord-285262-690kpupt	287	26	et	et	NNP
cord-285262-690kpupt	287	27	al	al	NNP
cord-285262-690kpupt	287	28	.	.	NNP
cord-285262-690kpupt	287	29	,	,	,
cord-285262-690kpupt	287	30	2010	2010	CD
cord-285262-690kpupt	287	31	)	)	-RRB-
cord-285262-690kpupt	287	32	.	.	.
cord-285262-690kpupt	288	1	Similar	similar	JJ
cord-285262-690kpupt	288	2	to	to	IN
cord-285262-690kpupt	288	3	IAV	IAV	NNP
cord-285262-690kpupt	288	4	infection	infection	NN
cord-285262-690kpupt	288	5	,	,	,
cord-285262-690kpupt	288	6	the	the	DT
cord-285262-690kpupt	288	7	RIPK3	ripk3	NN
cord-285262-690kpupt	288	8	driven	drive	VBN
cord-285262-690kpupt	288	9	necroptosis	necroptosis	NNP
cord-285262-690kpupt	288	10	is	be	VBZ
cord-285262-690kpupt	288	11	independent	independent	JJ
cord-285262-690kpupt	288	12	of	of	IN
cord-285262-690kpupt	288	13	the	the	DT
cord-285262-690kpupt	288	14	effect	effect	NN
cord-285262-690kpupt	288	15	of	of	IN
cord-285262-690kpupt	288	16	RIPK1	RIPK1	NNP
cord-285262-690kpupt	288	17	and	and	CC
cord-285262-690kpupt	288	18	the	the	DT
cord-285262-690kpupt	288	19	TNF	TNF	NNP
cord-285262-690kpupt	288	20	stimulation	stimulation	NN
cord-285262-690kpupt	288	21	,	,	,
cord-285262-690kpupt	288	22	but	but	CC
cord-285262-690kpupt	288	23	ZBP1	ZBP1	NNP
cord-285262-690kpupt	288	24	is	be	VBZ
cord-285262-690kpupt	288	25	activated	activate	VBN
cord-285262-690kpupt	288	26	via	via	IN
cord-285262-690kpupt	288	27	its	-PRON-	PRP$
cord-285262-690kpupt	288	28	putative	putative	JJ
cord-285262-690kpupt	288	29	RNA	RNA	NNP
cord-285262-690kpupt	288	30	binding	binding	NN
cord-285262-690kpupt	288	31	domain	domain	NN
cord-285262-690kpupt	288	32	Zα	Zα	NNP
cord-285262-690kpupt	288	33	(	(	-LRB-
cord-285262-690kpupt	288	34	Sridharan	Sridharan	NNP
cord-285262-690kpupt	288	35	et	et	NNP
cord-285262-690kpupt	288	36	al	al	NNP
cord-285262-690kpupt	288	37	.	.	NNP
cord-285262-690kpupt	288	38	,	,	,
cord-285262-690kpupt	288	39	2017	2017	CD
cord-285262-690kpupt	288	40	)	)	-RRB-
cord-285262-690kpupt	288	41	.	.	.
cord-285262-690kpupt	289	1	Analogously	analogously	RB
cord-285262-690kpupt	289	2	,	,	,
cord-285262-690kpupt	289	3	the	the	DT
cord-285262-690kpupt	289	4	Vaccinia	Vaccinia	NNP
cord-285262-690kpupt	289	5	virus	virus	NN
cord-285262-690kpupt	289	6	(	(	-LRB-
cord-285262-690kpupt	289	7	VACV	VACV	NNP
cord-285262-690kpupt	289	8	)	)	-RRB-
cord-285262-690kpupt	289	9	encoded	encode	VBD
cord-285262-690kpupt	289	10	innate	innate	JJ
cord-285262-690kpupt	289	11	immune	immune	JJ
cord-285262-690kpupt	289	12	evasion	evasion	NN
cord-285262-690kpupt	289	13	protein-3	protein-3	NN
cord-285262-690kpupt	290	1	(	(	-LRB-
cord-285262-690kpupt	290	2	E3	E3	NNP
cord-285262-690kpupt	290	3	)	)	-RRB-
cord-285262-690kpupt	290	4	can	can	MD
cord-285262-690kpupt	290	5	directly	directly	RB
cord-285262-690kpupt	290	6	interact	interact	VB
cord-285262-690kpupt	290	7	with	with	IN
cord-285262-690kpupt	290	8	the	the	DT
cord-285262-690kpupt	290	9	Zα	Zα	NNP
cord-285262-690kpupt	290	10	domain	domain	NN
cord-285262-690kpupt	290	11	of	of	IN
cord-285262-690kpupt	290	12	the	the	DT
cord-285262-690kpupt	290	13	ZBP1	ZBP1	NNP
cord-285262-690kpupt	290	14	.	.	.
cord-285262-690kpupt	291	1	Along	along	IN
cord-285262-690kpupt	291	2	with	with	IN
cord-285262-690kpupt	291	3	this	this	DT
cord-285262-690kpupt	291	4	,	,	,
cord-285262-690kpupt	291	5	E3	E3	NNP
cord-285262-690kpupt	291	6	deleted	delete	VBD
cord-285262-690kpupt	291	7	VACV	VACV	NNP
cord-285262-690kpupt	291	8	strain	strain	NN
cord-285262-690kpupt	291	9	triggers	trigger	VBZ
cord-285262-690kpupt	291	10	immediate	immediate	JJ
cord-285262-690kpupt	291	11	necroptosis	necroptosis	NN
cord-285262-690kpupt	291	12	in	in	IN
cord-285262-690kpupt	291	13	interferon	interferon	NN
cord-285262-690kpupt	291	14	treated	treat	VBN
cord-285262-690kpupt	291	15	mouse	mouse	NN
cord-285262-690kpupt	291	16	L292	L292	NNP
cord-285262-690kpupt	291	17	and	and	CC
cord-285262-690kpupt	291	18	human	human	JJ
cord-285262-690kpupt	291	19	embryonal	embryonal	JJ
cord-285262-690kpupt	291	20	kidney	kidney	NN
cord-285262-690kpupt	291	21	(	(	-LRB-
cord-285262-690kpupt	291	22	HEK293	HEK293	NNP
cord-285262-690kpupt	291	23	T	t	NN
cord-285262-690kpupt	291	24	)	)	-RRB-
cord-285262-690kpupt	291	25	cells	cell	NNS
cord-285262-690kpupt	291	26	.	.	.
cord-285262-690kpupt	292	1	The	the	DT
cord-285262-690kpupt	292	2	cytotoxic	cytotoxic	JJ
cord-285262-690kpupt	292	3	effect	effect	NN
cord-285262-690kpupt	292	4	of	of	IN
cord-285262-690kpupt	292	5	the	the	DT
cord-285262-690kpupt	292	6	engineered	engineer	VBN
cord-285262-690kpupt	292	7	VACV	VACV	NNP
cord-285262-690kpupt	292	8	strain	strain	NN
cord-285262-690kpupt	292	9	is	be	VBZ
cord-285262-690kpupt	292	10	attributed	attribute	VBN
cord-285262-690kpupt	292	11	to	to	IN
cord-285262-690kpupt	292	12	necroptotic	necroptotic	JJ
cord-285262-690kpupt	292	13	signaling	signaling	NN
cord-285262-690kpupt	292	14	,	,	,
cord-285262-690kpupt	292	15	because	because	IN
cord-285262-690kpupt	292	16	the	the	DT
cord-285262-690kpupt	292	17	pathogenicity	pathogenicity	NN
cord-285262-690kpupt	292	18	of	of	IN
cord-285262-690kpupt	292	19	the	the	DT
cord-285262-690kpupt	292	20	virus	virus	NN
cord-285262-690kpupt	292	21	can	can	MD
cord-285262-690kpupt	292	22	be	be	VB
cord-285262-690kpupt	292	23	restored	restore	VBN
cord-285262-690kpupt	292	24	in	in	IN
cord-285262-690kpupt	292	25	vivo	vivo	NN
cord-285262-690kpupt	292	26	by	by	IN
cord-285262-690kpupt	292	27	the	the	DT
cord-285262-690kpupt	292	28	depletion	depletion	NN
cord-285262-690kpupt	292	29	of	of	IN
cord-285262-690kpupt	292	30	either	either	DT
cord-285262-690kpupt	292	31	RIPK3	RIPK3	NNS
cord-285262-690kpupt	292	32	or	or	CC
cord-285262-690kpupt	292	33	ZBP1	ZBP1	NNP
cord-285262-690kpupt	292	34	in	in	IN
cord-285262-690kpupt	292	35	mice	mouse	NNS
cord-285262-690kpupt	292	36	(	(	-LRB-
cord-285262-690kpupt	292	37	Koehler	Koehler	NNP
cord-285262-690kpupt	292	38	et	et	NNP
cord-285262-690kpupt	292	39	al	al	NNP
cord-285262-690kpupt	292	40	.	.	NNP
cord-285262-690kpupt	292	41	,	,	,
cord-285262-690kpupt	292	42	2017	2017	CD
cord-285262-690kpupt	292	43	)	)	-RRB-
cord-285262-690kpupt	292	44	.	.	.
cord-285262-690kpupt	293	1	The	the	DT
cord-285262-690kpupt	293	2	large	large	JJ
cord-285262-690kpupt	293	3	subunit	subunit	NN
cord-285262-690kpupt	293	4	of	of	IN
cord-285262-690kpupt	293	5	the	the	DT
cord-285262-690kpupt	293	6	viral	viral	JJ
cord-285262-690kpupt	293	7	ribonucleotide	ribonucleotide	NN
cord-285262-690kpupt	293	8	reductase	reductase	NN
cord-285262-690kpupt	293	9	ICP6	ICP6	NNP
cord-285262-690kpupt	294	1	(	(	-LRB-
cord-285262-690kpupt	294	2	Fig	Fig	NNP
cord-285262-690kpupt	294	3	.	.	NNP
cord-285262-690kpupt	294	4	2	2	LS
cord-285262-690kpupt	294	5	)	)	-RRB-
cord-285262-690kpupt	294	6	is	be	VBZ
cord-285262-690kpupt	294	7	capable	capable	JJ
cord-285262-690kpupt	294	8	to	to	TO
cord-285262-690kpupt	294	9	engage	engage	VB
cord-285262-690kpupt	294	10	both	both	DT
cord-285262-690kpupt	294	11	RIPK1	RIPK1	NNS
cord-285262-690kpupt	294	12	and	and	CC
cord-285262-690kpupt	294	13	RIPK3	ripk3	NN
cord-285262-690kpupt	294	14	through	through	IN
cord-285262-690kpupt	294	15	its	-PRON-	PRP$
cord-285262-690kpupt	294	16	RHIM	RHIM	NNP
cord-285262-690kpupt	294	17	-	-	HYPH
cord-285262-690kpupt	294	18	like	like	JJ
cord-285262-690kpupt	294	19	domain	domain	NN
cord-285262-690kpupt	294	20	upon	upon	IN
cord-285262-690kpupt	294	21	herpes	herpes	NNP
cord-285262-690kpupt	294	22	simplex	simplex	NNP
cord-285262-690kpupt	294	23	virus	virus	NN
cord-285262-690kpupt	294	24	type	type	NN
cord-285262-690kpupt	294	25	1	1	CD
cord-285262-690kpupt	294	26	(	(	-LRB-
cord-285262-690kpupt	294	27	HSV-1	hsv-1	NN
cord-285262-690kpupt	294	28	)	)	-RRB-
cord-285262-690kpupt	294	29	infection	infection	NN
cord-285262-690kpupt	294	30	and	and	CC
cord-285262-690kpupt	294	31	to	to	TO
cord-285262-690kpupt	294	32	result	result	VB
cord-285262-690kpupt	294	33	in	in	IN
cord-285262-690kpupt	294	34	necroptosis	necroptosis	NNP
cord-285262-690kpupt	294	35	,	,	,
cord-285262-690kpupt	294	36	which	which	WDT
cord-285262-690kpupt	294	37	also	also	RB
cord-285262-690kpupt	294	38	contributes	contribute	VBZ
cord-285262-690kpupt	294	39	to	to	IN
cord-285262-690kpupt	294	40	the	the	DT
cord-285262-690kpupt	294	41	limited	limited	JJ
cord-285262-690kpupt	294	42	viral	viral	JJ
cord-285262-690kpupt	294	43	propagation	propagation	NN
cord-285262-690kpupt	294	44	in	in	IN
cord-285262-690kpupt	294	45	mice	mouse	NNS
cord-285262-690kpupt	294	46	.	.	.
cord-285262-690kpupt	295	1	Intriguingly	intriguingly	RB
cord-285262-690kpupt	295	2	,	,	,
cord-285262-690kpupt	295	3	ICP6	ICP6	NNP
cord-285262-690kpupt	295	4	inhibits	inhibit	VBZ
cord-285262-690kpupt	295	5	the	the	DT
cord-285262-690kpupt	295	6	necroptosis	necroptosis	NN
cord-285262-690kpupt	295	7	signaling	signal	VBG
cord-285262-690kpupt	295	8	in	in	IN
cord-285262-690kpupt	295	9	its	-PRON-	PRP$
cord-285262-690kpupt	295	10	natural	natural	JJ
cord-285262-690kpupt	295	11	host	host	NN
cord-285262-690kpupt	295	12	,	,	,
cord-285262-690kpupt	295	13	in	in	IN
cord-285262-690kpupt	295	14	human	human	JJ
cord-285262-690kpupt	295	15	cells	cell	NNS
cord-285262-690kpupt	295	16	.	.	.
cord-285262-690kpupt	296	1	This	this	DT
cord-285262-690kpupt	296	2	observation	observation	NN
cord-285262-690kpupt	296	3	points	point	VBZ
cord-285262-690kpupt	296	4	out	out	RP
cord-285262-690kpupt	296	5	the	the	DT
cord-285262-690kpupt	296	6	species	species	NN
cord-285262-690kpupt	296	7	-	-	HYPH
cord-285262-690kpupt	296	8	specific	specific	JJ
cord-285262-690kpupt	296	9	differences	difference	NNS
cord-285262-690kpupt	296	10	in	in	IN
cord-285262-690kpupt	296	11	cell	cell	NN
cord-285262-690kpupt	296	12	death	death	NN
cord-285262-690kpupt	296	13	signaling	signal	VBG
cord-285262-690kpupt	296	14	pathways	pathway	NNS
cord-285262-690kpupt	296	15	and	and	CC
cord-285262-690kpupt	296	16	indicates	indicate	VBZ
cord-285262-690kpupt	296	17	that	that	IN
cord-285262-690kpupt	296	18	viruses	virus	NNS
cord-285262-690kpupt	296	19	in	in	IN
cord-285262-690kpupt	296	20	their	-PRON-	PRP$
cord-285262-690kpupt	296	21	natural	natural	JJ
cord-285262-690kpupt	296	22	hosts	host	NNS
cord-285262-690kpupt	296	23	evolved	evolve	VBD
cord-285262-690kpupt	296	24	to	to	TO
cord-285262-690kpupt	296	25	overcome	overcome	VB
cord-285262-690kpupt	296	26	host	host	NN
cord-285262-690kpupt	296	27	defense	defense	NN
cord-285262-690kpupt	296	28	mechanisms	mechanism	NNS
cord-285262-690kpupt	296	29	.	.	.
cord-285262-690kpupt	297	1	HSV-1	HSV-1	NNP
cord-285262-690kpupt	297	2	induces	induce	VBZ
cord-285262-690kpupt	297	3	necroptosis	necroptosis	NNP
cord-285262-690kpupt	297	4	not	not	RB
cord-285262-690kpupt	297	5	only	only	RB
cord-285262-690kpupt	297	6	via	via	IN
cord-285262-690kpupt	297	7	its	-PRON-	PRP$
cord-285262-690kpupt	297	8	ICP6	ICP6	NNP
cord-285262-690kpupt	297	9	protein	protein	NN
cord-285262-690kpupt	297	10	,	,	,
cord-285262-690kpupt	297	11	but	but	CC
cord-285262-690kpupt	297	12	also	also	RB
cord-285262-690kpupt	297	13	by	by	IN
cord-285262-690kpupt	297	14	triggering	trigger	VBG
cord-285262-690kpupt	297	15	the	the	DT
cord-285262-690kpupt	297	16	ZBP1	ZBP1	NNP
cord-285262-690kpupt	297	17	pathway	pathway	NN
cord-285262-690kpupt	297	18	in	in	IN
cord-285262-690kpupt	297	19	mice	mouse	NNS
cord-285262-690kpupt	297	20	.	.	.
cord-285262-690kpupt	298	1	Conversely	conversely	RB
cord-285262-690kpupt	298	2	,	,	,
cord-285262-690kpupt	298	3	in	in	IN
cord-285262-690kpupt	298	4	order	order	NN
cord-285262-690kpupt	298	5	to	to	TO
cord-285262-690kpupt	298	6	induce	induce	VB
cord-285262-690kpupt	298	7	the	the	DT
cord-285262-690kpupt	298	8	necroptotic	necroptotic	JJ
cord-285262-690kpupt	298	9	pathway	pathway	NN
cord-285262-690kpupt	298	10	in	in	IN
cord-285262-690kpupt	298	11	human	human	JJ
cord-285262-690kpupt	298	12	cells	cell	NNS
cord-285262-690kpupt	298	13	,	,	,
cord-285262-690kpupt	298	14	the	the	DT
cord-285262-690kpupt	298	15	expression	expression	NN
cord-285262-690kpupt	298	16	of	of	IN
cord-285262-690kpupt	298	17	ZBP1	ZBP1	NNP
cord-285262-690kpupt	298	18	has	have	VBZ
cord-285262-690kpupt	298	19	to	to	TO
cord-285262-690kpupt	298	20	be	be	VB
cord-285262-690kpupt	298	21	first	first	RB
cord-285262-690kpupt	298	22	enhanced	enhance	VBN
cord-285262-690kpupt	298	23	.	.	.
cord-285262-690kpupt	299	1	Moreover	moreover	RB
cord-285262-690kpupt	299	2	,	,	,
cord-285262-690kpupt	299	3	ICP10	ICP10	NNP
cord-285262-690kpupt	299	4	,	,	,
cord-285262-690kpupt	299	5	the	the	DT
cord-285262-690kpupt	299	6	virally	virally	RB
cord-285262-690kpupt	299	7	encoded	encode	VBN
cord-285262-690kpupt	299	8	large	large	JJ
cord-285262-690kpupt	299	9	subunit	subunit	NN
cord-285262-690kpupt	299	10	of	of	IN
cord-285262-690kpupt	299	11	the	the	DT
cord-285262-690kpupt	299	12	ribonucleotide	ribonucleotide	NN
cord-285262-690kpupt	299	13	reductase	reductase	NN
cord-285262-690kpupt	299	14	of	of	IN
cord-285262-690kpupt	299	15	HSV-2	HSV-2	NNP
cord-285262-690kpupt	299	16	,	,	,
cord-285262-690kpupt	299	17	can	can	MD
cord-285262-690kpupt	299	18	efficiently	efficiently	RB
cord-285262-690kpupt	299	19	prevent	prevent	VB
cord-285262-690kpupt	299	20	necroptosis	necroptosis	NN
cord-285262-690kpupt	299	21	that	that	WDT
cord-285262-690kpupt	299	22	is	be	VBZ
cord-285262-690kpupt	299	23	induced	induce	VBN
cord-285262-690kpupt	299	24	by	by	IN
cord-285262-690kpupt	299	25	TNFα	TNFα	NNS
cord-285262-690kpupt	299	26	.	.	.
cord-285262-690kpupt	300	1	One	one	CD
cord-285262-690kpupt	300	2	possible	possible	JJ
cord-285262-690kpupt	300	3	explanation	explanation	NN
cord-285262-690kpupt	300	4	for	for	IN
cord-285262-690kpupt	300	5	the	the	DT
cord-285262-690kpupt	300	6	difference	difference	NN
cord-285262-690kpupt	300	7	between	between	IN
cord-285262-690kpupt	300	8	mice	mouse	NNS
cord-285262-690kpupt	300	9	and	and	CC
cord-285262-690kpupt	300	10	human	human	JJ
cord-285262-690kpupt	300	11	responses	response	NNS
cord-285262-690kpupt	300	12	might	may	MD
cord-285262-690kpupt	300	13	be	be	VB
cord-285262-690kpupt	300	14	provided	provide	VBN
cord-285262-690kpupt	300	15	by	by	IN
cord-285262-690kpupt	300	16	a	a	DT
cord-285262-690kpupt	300	17	recent	recent	JJ
cord-285262-690kpupt	300	18	study	study	NN
cord-285262-690kpupt	300	19	on	on	IN
cord-285262-690kpupt	300	20	HSV-1	HSV-1	NNS
cord-285262-690kpupt	300	21	demonstrating	demonstrate	VBG
cord-285262-690kpupt	300	22	that	that	IN
cord-285262-690kpupt	300	23	ICP6	ICP6	NNP
cord-285262-690kpupt	300	24	blocks	block	NNS
cord-285262-690kpupt	300	25	TNFR1	tnfr1	XX
cord-285262-690kpupt	300	26	induced	induce	VBD
cord-285262-690kpupt	300	27	MLKL	MLKL	NNP
cord-285262-690kpupt	300	28	necrosome	necrosome	NN
cord-285262-690kpupt	300	29	assembly	assembly	NN
cord-285262-690kpupt	300	30	in	in	IN
cord-285262-690kpupt	300	31	membrane	membrane	NN
cord-285262-690kpupt	300	32	vesicles	vesicle	NNS
cord-285262-690kpupt	300	33	(	(	-LRB-
cord-285262-690kpupt	301	1	Ali	Ali	NNP
cord-285262-690kpupt	301	2	et	et	NNP
cord-285262-690kpupt	301	3	al	al	NNP
cord-285262-690kpupt	301	4	.	.	NNP
cord-285262-690kpupt	301	5	,	,	,
cord-285262-690kpupt	301	6	2019	2019	CD
cord-285262-690kpupt	301	7	)	)	-RRB-
cord-285262-690kpupt	301	8	.	.	.
cord-285262-690kpupt	302	1	This	this	DT
cord-285262-690kpupt	302	2	compartmentalization	compartmentalization	NN
cord-285262-690kpupt	302	3	process	process	NN
cord-285262-690kpupt	302	4	of	of	IN
cord-285262-690kpupt	302	5	the	the	DT
cord-285262-690kpupt	302	6	necrosome	necrosome	NN
cord-285262-690kpupt	302	7	represents	represent	VBZ
cord-285262-690kpupt	302	8	a	a	DT
cord-285262-690kpupt	302	9	critical	critical	JJ
cord-285262-690kpupt	302	10	step	step	NN
cord-285262-690kpupt	302	11	for	for	IN
cord-285262-690kpupt	302	12	the	the	DT
cord-285262-690kpupt	302	13	progression	progression	NN
cord-285262-690kpupt	302	14	of	of	IN
cord-285262-690kpupt	302	15	necroptosis	necroptosis	NNP
cord-285262-690kpupt	302	16	in	in	IN
cord-285262-690kpupt	302	17	human	human	JJ
cord-285262-690kpupt	302	18	cells	cell	NNS
cord-285262-690kpupt	302	19	.	.	.
cord-285262-690kpupt	303	1	Consistent	consistent	JJ
cord-285262-690kpupt	303	2	with	with	IN
cord-285262-690kpupt	303	3	this	this	DT
cord-285262-690kpupt	303	4	,	,	,
cord-285262-690kpupt	303	5	RHIM	rhim	NN
cord-285262-690kpupt	303	6	domain	domain	NN
cord-285262-690kpupt	303	7	deficient	deficient	JJ
cord-285262-690kpupt	303	8	RIPK3	ripk3	NN
cord-285262-690kpupt	303	9	can	can	MD
cord-285262-690kpupt	303	10	efficiently	efficiently	RB
cord-285262-690kpupt	303	11	phosphorylate	phosphorylate	VB
cord-285262-690kpupt	303	12	MLKL	MLKL	NNP
cord-285262-690kpupt	303	13	but	but	CC
cord-285262-690kpupt	303	14	does	do	VBZ
cord-285262-690kpupt	303	15	not	not	RB
cord-285262-690kpupt	303	16	lead	lead	VB
cord-285262-690kpupt	303	17	to	to	IN
cord-285262-690kpupt	303	18	necroptosis	necroptosis	NNP
cord-285262-690kpupt	303	19	in	in	IN
cord-285262-690kpupt	303	20	human	human	JJ
cord-285262-690kpupt	303	21	cells	cell	NNS
cord-285262-690kpupt	303	22	.	.	.
cord-285262-690kpupt	304	1	Thus	thus	RB
cord-285262-690kpupt	304	2	,	,	,
cord-285262-690kpupt	304	3	one	one	PRP
cord-285262-690kpupt	304	4	can	can	MD
cord-285262-690kpupt	304	5	speculate	speculate	VB
cord-285262-690kpupt	304	6	that	that	IN
cord-285262-690kpupt	304	7	ICP6	ICP6	NNP
cord-285262-690kpupt	304	8	can	can	MD
cord-285262-690kpupt	304	9	trigger	trigger	VB
cord-285262-690kpupt	304	10	necrosome	necrosome	NN
cord-285262-690kpupt	304	11	formation	formation	NN
cord-285262-690kpupt	304	12	in	in	IN
cord-285262-690kpupt	304	13	mice	mouse	NNS
cord-285262-690kpupt	304	14	,	,	,
cord-285262-690kpupt	304	15	because	because	IN
cord-285262-690kpupt	304	16	the	the	DT
cord-285262-690kpupt	304	17	compartmentalization	compartmentalization	NN
cord-285262-690kpupt	304	18	step	step	NN
cord-285262-690kpupt	304	19	may	may	MD
cord-285262-690kpupt	304	20	not	not	RB
cord-285262-690kpupt	304	21	be	be	VB
cord-285262-690kpupt	304	22	required	require	VBN
cord-285262-690kpupt	304	23	for	for	IN
cord-285262-690kpupt	304	24	the	the	DT
cord-285262-690kpupt	304	25	effector	effector	NN
cord-285262-690kpupt	304	26	mechanisms	mechanism	NNS
cord-285262-690kpupt	304	27	of	of	IN
cord-285262-690kpupt	304	28	necroptosis	necroptosis	NNP
cord-285262-690kpupt	304	29	.	.	.
cord-285262-690kpupt	305	1	Additionally	additionally	RB
cord-285262-690kpupt	305	2	,	,	,
cord-285262-690kpupt	305	3	inositol	inositol	NN
cord-285262-690kpupt	305	4	phosphate	phosphate	NN
cord-285262-690kpupt	305	5	(	(	-LRB-
cord-285262-690kpupt	305	6	IP	ip	NN
cord-285262-690kpupt	305	7	)	)	-RRB-
cord-285262-690kpupt	305	8	kinases	kinase	NNS
cord-285262-690kpupt	305	9	largely	largely	RB
cord-285262-690kpupt	305	10	contribute	contribute	VBP
cord-285262-690kpupt	305	11	to	to	IN
cord-285262-690kpupt	305	12	the	the	DT
cord-285262-690kpupt	305	13	oligomerization	oligomerization	NN
cord-285262-690kpupt	305	14	of	of	IN
cord-285262-690kpupt	305	15	MLKL	MLKL	NNP
cord-285262-690kpupt	305	16	.	.	.
cord-285262-690kpupt	306	1	IP	IP	NNP
cord-285262-690kpupt	306	2	kinase	kinase	NN
cord-285262-690kpupt	306	3	mutants	mutant	NNS
cord-285262-690kpupt	306	4	are	be	VBP
cord-285262-690kpupt	306	5	unable	unable	JJ
cord-285262-690kpupt	306	6	to	to	TO
cord-285262-690kpupt	306	7	achieve	achieve	VB
cord-285262-690kpupt	306	8	the	the	DT
cord-285262-690kpupt	306	9	MLKL	MLKL	NNP
cord-285262-690kpupt	306	10	oligomerization	oligomerization	NN
cord-285262-690kpupt	306	11	and	and	CC
cord-285262-690kpupt	306	12	membrane	membrane	NN
cord-285262-690kpupt	306	13	localization	localization	NN
cord-285262-690kpupt	306	14	despite	despite	IN
cord-285262-690kpupt	306	15	a	a	DT
cord-285262-690kpupt	306	16	functioning	function	VBG
cord-285262-690kpupt	306	17	RIPK3	ripk3	NN
cord-285262-690kpupt	306	18	in	in	IN
cord-285262-690kpupt	306	19	response	response	NN
cord-285262-690kpupt	306	20	to	to	IN
cord-285262-690kpupt	306	21	a	a	DT
cord-285262-690kpupt	306	22	genetically	genetically	RB
cord-285262-690kpupt	306	23	engineered	engineer	VBN
cord-285262-690kpupt	306	24	ICP-6	ICP-6	NNP
cord-285262-690kpupt	306	25	mutant	mutant	JJ
cord-285262-690kpupt	306	26	HSV-1	hsv-1	NN
cord-285262-690kpupt	306	27	infection	infection	NN
cord-285262-690kpupt	306	28	.	.	.
cord-285262-690kpupt	307	1	This	this	DT
cord-285262-690kpupt	307	2	study	study	NN
cord-285262-690kpupt	307	3	suggests	suggest	VBZ
cord-285262-690kpupt	307	4	that	that	IN
cord-285262-690kpupt	307	5	the	the	DT
cord-285262-690kpupt	307	6	RIPK3	ripk3	NN
cord-285262-690kpupt	307	7	dependent	dependent	JJ
cord-285262-690kpupt	307	8	phosphorylation	phosphorylation	NN
cord-285262-690kpupt	307	9	at	at	IN
cord-285262-690kpupt	307	10	the	the	DT
cord-285262-690kpupt	307	11	C	C	NNP
cord-285262-690kpupt	307	12	-	-	HYPH
cord-285262-690kpupt	307	13	terminal	terminal	NN
cord-285262-690kpupt	307	14	Ser358	Ser358	NNP
cord-285262-690kpupt	307	15	and	and	CC
cord-285262-690kpupt	307	16	the	the	DT
cord-285262-690kpupt	307	17	subsequent	subsequent	JJ
cord-285262-690kpupt	307	18	events	event	NNS
cord-285262-690kpupt	307	19	,	,	,
cord-285262-690kpupt	307	20	such	such	JJ
cord-285262-690kpupt	307	21	as	as	IN
cord-285262-690kpupt	307	22	oligomerization	oligomerization	NN
cord-285262-690kpupt	307	23	and	and	CC
cord-285262-690kpupt	307	24	membrane	membrane	NN
cord-285262-690kpupt	307	25	localization	localization	NN
cord-285262-690kpupt	307	26	are	be	VBP
cord-285262-690kpupt	307	27	separately	separately	RB
cord-285262-690kpupt	307	28	regulated	regulate	VBN
cord-285262-690kpupt	307	29	in	in	IN
cord-285262-690kpupt	307	30	human	human	JJ
cord-285262-690kpupt	307	31	cells	cell	NNS
cord-285262-690kpupt	307	32	.	.	.
cord-285262-690kpupt	308	1	Accordingly	accordingly	RB
cord-285262-690kpupt	308	2	,	,	,
cord-285262-690kpupt	308	3	in	in	IN
cord-285262-690kpupt	308	4	order	order	NN
cord-285262-690kpupt	308	5	to	to	TO
cord-285262-690kpupt	308	6	accomplish	accomplish	VB
cord-285262-690kpupt	308	7	necroptosis	necroptosis	NNP
cord-285262-690kpupt	308	8	,	,	,
cord-285262-690kpupt	308	9	MLKL	MLKL	NNP
cord-285262-690kpupt	308	10	activation	activation	NN
cord-285262-690kpupt	308	11	requires	require	VBZ
cord-285262-690kpupt	308	12	a	a	DT
cord-285262-690kpupt	308	13	highly	highly	RB
cord-285262-690kpupt	308	14	phosphorylated	phosphorylate	VBN
cord-285262-690kpupt	308	15	IP	ip	NN
cord-285262-690kpupt	308	16	product	product	NN
cord-285262-690kpupt	308	17	to	to	TO
cord-285262-690kpupt	308	18	bind	bind	VB
cord-285262-690kpupt	308	19	to	to	IN
cord-285262-690kpupt	308	20	the	the	DT
cord-285262-690kpupt	308	21	N	n	CD
cord-285262-690kpupt	308	22	-	-	HYPH
cord-285262-690kpupt	308	23	terminal	terminal	NN
cord-285262-690kpupt	308	24	domain	domain	NN
cord-285262-690kpupt	308	25	.	.	.
cord-285262-690kpupt	309	1	It	-PRON-	PRP
cord-285262-690kpupt	309	2	is	be	VBZ
cord-285262-690kpupt	309	3	currently	currently	RB
cord-285262-690kpupt	309	4	not	not	RB
cord-285262-690kpupt	309	5	clear	clear	JJ
cord-285262-690kpupt	309	6	what	what	WP
cord-285262-690kpupt	309	7	the	the	DT
cord-285262-690kpupt	309	8	exact	exact	JJ
cord-285262-690kpupt	309	9	role	role	NN
cord-285262-690kpupt	309	10	of	of	IN
cord-285262-690kpupt	309	11	the	the	DT
cord-285262-690kpupt	309	12	highly	highly	RB
cord-285262-690kpupt	309	13	phosphorylated	phosphorylated	JJ
cord-285262-690kpupt	309	14	product	product	NN
cord-285262-690kpupt	309	15	can	can	MD
cord-285262-690kpupt	309	16	be	be	VB
cord-285262-690kpupt	309	17	,	,	,
cord-285262-690kpupt	309	18	nevertheless	nevertheless	RB
cord-285262-690kpupt	309	19	the	the	DT
cord-285262-690kpupt	309	20	stabilization	stabilization	NN
cord-285262-690kpupt	309	21	of	of	IN
cord-285262-690kpupt	309	22	the	the	DT
cord-285262-690kpupt	309	23	oligomerized	oligomerize	VBN
cord-285262-690kpupt	309	24	MLKL	MLKL	NNP
cord-285262-690kpupt	309	25	complex	complex	NN
cord-285262-690kpupt	309	26	can	can	MD
cord-285262-690kpupt	309	27	serve	serve	VB
cord-285262-690kpupt	309	28	as	as	IN
cord-285262-690kpupt	309	29	one	one	CD
cord-285262-690kpupt	309	30	plausible	plausible	JJ
cord-285262-690kpupt	309	31	explanation	explanation	NN
cord-285262-690kpupt	309	32	.	.	.
cord-285262-690kpupt	310	1	The	the	DT
cord-285262-690kpupt	310	2	latent	latent	JJ
cord-285262-690kpupt	310	3	membrane	membrane	NN
cord-285262-690kpupt	310	4	protein-1	protein-1	NNP
cord-285262-690kpupt	310	5	(	(	-LRB-
cord-285262-690kpupt	310	6	LMP1	LMP1	NNP
cord-285262-690kpupt	310	7	)	)	-RRB-
cord-285262-690kpupt	310	8	of	of	IN
cord-285262-690kpupt	310	9	the	the	DT
cord-285262-690kpupt	310	10	γ	γ	NN
cord-285262-690kpupt	310	11	-	-	HYPH
cord-285262-690kpupt	310	12	herpes	herpes	NNP
cord-285262-690kpupt	310	13	virus	virus	NN
cord-285262-690kpupt	310	14	Epstein	Epstein	NNP
cord-285262-690kpupt	310	15	-	-	HYPH
cord-285262-690kpupt	310	16	Barr	Barr	NNP
cord-285262-690kpupt	310	17	virus	virus	NN
cord-285262-690kpupt	310	18	(	(	-LRB-
cord-285262-690kpupt	310	19	EBV	EBV	NNP
cord-285262-690kpupt	310	20	)	)	-RRB-
cord-285262-690kpupt	310	21	is	be	VBZ
cord-285262-690kpupt	310	22	considered	consider	VBN
cord-285262-690kpupt	310	23	as	as	IN
cord-285262-690kpupt	310	24	the	the	DT
cord-285262-690kpupt	310	25	major	major	JJ
cord-285262-690kpupt	310	26	transforming	transform	VBG
cord-285262-690kpupt	310	27	factor	factor	NN
cord-285262-690kpupt	310	28	of	of	IN
cord-285262-690kpupt	310	29	the	the	DT
cord-285262-690kpupt	310	30	pathogen	pathogen	NN
cord-285262-690kpupt	310	31	.	.	.
cord-285262-690kpupt	311	1	Initially	initially	RB
cord-285262-690kpupt	311	2	,	,	,
cord-285262-690kpupt	311	3	this	this	DT
cord-285262-690kpupt	311	4	transmembrane	transmembrane	NN
cord-285262-690kpupt	311	5	protein	protein	NN
cord-285262-690kpupt	311	6	has	have	VBZ
cord-285262-690kpupt	311	7	been	be	VBN
cord-285262-690kpupt	311	8	reported	report	VBN
cord-285262-690kpupt	311	9	to	to	TO
cord-285262-690kpupt	311	10	exert	exert	VB
cord-285262-690kpupt	311	11	antiapoptotic	antiapoptotic	JJ
cord-285262-690kpupt	311	12	effects	effect	NNS
cord-285262-690kpupt	311	13	in	in	IN
cord-285262-690kpupt	311	14	B	b	NN
cord-285262-690kpupt	311	15	cells	cell	NNS
cord-285262-690kpupt	312	1	(	(	-LRB-
cord-285262-690kpupt	312	2	Henderson	Henderson	NNP
cord-285262-690kpupt	312	3	et	et	NNP
cord-285262-690kpupt	312	4	al	al	NNP
cord-285262-690kpupt	312	5	.	.	NNP
cord-285262-690kpupt	312	6	,	,	,
cord-285262-690kpupt	312	7	1991	1991	CD
cord-285262-690kpupt	312	8	)	)	-RRB-
cord-285262-690kpupt	312	9	.	.	.
cord-285262-690kpupt	313	1	Later	later	RBR
cord-285262-690kpupt	313	2	,	,	,
cord-285262-690kpupt	313	3	LMP1	LMP1	NNP
cord-285262-690kpupt	313	4	has	have	VBZ
cord-285262-690kpupt	313	5	been	be	VBN
cord-285262-690kpupt	313	6	associated	associate	VBN
cord-285262-690kpupt	313	7	with	with	IN
cord-285262-690kpupt	313	8	necroptosis	necroptosis	NN
cord-285262-690kpupt	313	9	inhibition	inhibition	NN
cord-285262-690kpupt	313	10	in	in	IN
cord-285262-690kpupt	313	11	EBV	EBV	NNP
cord-285262-690kpupt	313	12	-	-	HYPH
cord-285262-690kpupt	313	13	infected	infect	VBN
cord-285262-690kpupt	313	14	human	human	JJ
cord-285262-690kpupt	313	15	nasopharyngeal	nasopharyngeal	JJ
cord-285262-690kpupt	313	16	epithelial	epithelial	JJ
cord-285262-690kpupt	313	17	cells	cell	NNS
cord-285262-690kpupt	313	18	and	and	CC
cord-285262-690kpupt	313	19	nasopharyngeal	nasopharyngeal	JJ
cord-285262-690kpupt	313	20	carcinoma	carcinoma	NN
cord-285262-690kpupt	313	21	cells	cell	NNS
cord-285262-690kpupt	313	22	.	.	.
cord-285262-690kpupt	314	1	LMP1	LMP1	NNP
cord-285262-690kpupt	314	2	can	can	MD
cord-285262-690kpupt	314	3	interact	interact	VB
cord-285262-690kpupt	314	4	both	both	DT
cord-285262-690kpupt	314	5	RIPKs	ripk	NNS
cord-285262-690kpupt	314	6	and	and	CC
cord-285262-690kpupt	314	7	can	can	MD
cord-285262-690kpupt	314	8	successfully	successfully	RB
cord-285262-690kpupt	314	9	mediate	mediate	VB
cord-285262-690kpupt	314	10	the	the	DT
cord-285262-690kpupt	314	11	polyubiquitination	polyubiquitination	NN
cord-285262-690kpupt	314	12	of	of	IN
cord-285262-690kpupt	314	13	them	-PRON-	PRP
cord-285262-690kpupt	314	14	,	,	,
cord-285262-690kpupt	314	15	which	which	WDT
cord-285262-690kpupt	314	16	in	in	IN
cord-285262-690kpupt	314	17	turn	turn	NN
cord-285262-690kpupt	314	18	leads	lead	VBZ
cord-285262-690kpupt	314	19	to	to	IN
cord-285262-690kpupt	314	20	the	the	DT
cord-285262-690kpupt	314	21	inhibition	inhibition	NN
cord-285262-690kpupt	314	22	of	of	IN
cord-285262-690kpupt	314	23	the	the	DT
cord-285262-690kpupt	314	24	kinase	kinase	NN
cord-285262-690kpupt	314	25	function	function	NN
cord-285262-690kpupt	314	26	of	of	IN
cord-285262-690kpupt	314	27	the	the	DT
cord-285262-690kpupt	314	28	RIPK3	RIPK3	NNS
cord-285262-690kpupt	314	29	and	and	CC
cord-285262-690kpupt	314	30	activates	activate	VBZ
cord-285262-690kpupt	314	31	the	the	DT
cord-285262-690kpupt	314	32	pro	pro	JJ
cord-285262-690kpupt	314	33	-	-	JJ
cord-285262-690kpupt	314	34	survival	survival	JJ
cord-285262-690kpupt	314	35	pathway	pathway	NN
cord-285262-690kpupt	314	36	.	.	.
cord-285262-690kpupt	315	1	As	as	IN
cord-285262-690kpupt	315	2	previously	previously	RB
cord-285262-690kpupt	315	3	discussed	discuss	VBN
cord-285262-690kpupt	315	4	,	,	,
cord-285262-690kpupt	315	5	the	the	DT
cord-285262-690kpupt	315	6	vIRA	vira	JJ
cord-285262-690kpupt	315	7	protein	protein	NN
cord-285262-690kpupt	315	8	of	of	IN
cord-285262-690kpupt	315	9	MCMV	MCMV	NNP
cord-285262-690kpupt	315	10	can	can	MD
cord-285262-690kpupt	315	11	efficiently	efficiently	RB
cord-285262-690kpupt	315	12	block	block	VB
cord-285262-690kpupt	315	13	RIPKs	ripk	NNS
cord-285262-690kpupt	315	14	and	and	CC
cord-285262-690kpupt	315	15	hamper	hamper	VB
cord-285262-690kpupt	315	16	the	the	DT
cord-285262-690kpupt	315	17	necroptotic	necroptotic	JJ
cord-285262-690kpupt	315	18	signaling	signaling	NN
cord-285262-690kpupt	315	19	.	.	.
cord-285262-690kpupt	316	1	Though	though	RB
cord-285262-690kpupt	316	2	,	,	,
cord-285262-690kpupt	316	3	distinct	distinct	JJ
cord-285262-690kpupt	316	4	from	from	IN
cord-285262-690kpupt	316	5	the	the	DT
cord-285262-690kpupt	316	6	necroptosis	necroptosis	NNP
cord-285262-690kpupt	316	7	inhibitory	inhibitory	JJ
cord-285262-690kpupt	316	8	mechanism	mechanism	NN
cord-285262-690kpupt	316	9	of	of	IN
cord-285262-690kpupt	316	10	the	the	DT
cord-285262-690kpupt	316	11	vIRA	vira	JJ
cord-285262-690kpupt	316	12	protein	protein	NN
cord-285262-690kpupt	316	13	,	,	,
cord-285262-690kpupt	316	14	the	the	DT
cord-285262-690kpupt	316	15	human	human	JJ
cord-285262-690kpupt	316	16	CMV	CMV	NNP
cord-285262-690kpupt	316	17	has	have	VBZ
cord-285262-690kpupt	316	18	also	also	RB
cord-285262-690kpupt	316	19	developed	develop	VBN
cord-285262-690kpupt	316	20	a	a	DT
cord-285262-690kpupt	316	21	strategy	strategy	NN
cord-285262-690kpupt	316	22	to	to	TO
cord-285262-690kpupt	316	23	suppress	suppress	VB
cord-285262-690kpupt	316	24	necroptosis	necroptosis	NN
cord-285262-690kpupt	316	25	upstream	upstream	RB
cord-285262-690kpupt	316	26	of	of	IN
cord-285262-690kpupt	316	27	MLKL	MLKL	NNP
cord-285262-690kpupt	316	28	phosphorylation	phosphorylation	NN
cord-285262-690kpupt	316	29	.	.	.
cord-285262-690kpupt	317	1	Furthermore	furthermore	RB
cord-285262-690kpupt	317	2	,	,	,
cord-285262-690kpupt	317	3	Rhinoviruses	Rhinoviruses	NNP
cord-285262-690kpupt	317	4	,	,	,
cord-285262-690kpupt	317	5	the	the	DT
cord-285262-690kpupt	317	6	causative	causative	JJ
cord-285262-690kpupt	317	7	agents	agent	NNS
cord-285262-690kpupt	317	8	of	of	IN
cord-285262-690kpupt	317	9	common	common	JJ
cord-285262-690kpupt	317	10	cold	cold	NN
cord-285262-690kpupt	317	11	can	can	MD
cord-285262-690kpupt	317	12	actively	actively	RB
cord-285262-690kpupt	317	13	suppress	suppress	VB
cord-285262-690kpupt	317	14	both	both	DT
cord-285262-690kpupt	317	15	apoptosis	apoptosis	NN
cord-285262-690kpupt	317	16	and	and	CC
cord-285262-690kpupt	317	17	necroptosis	necroptosis	NN
cord-285262-690kpupt	317	18	.	.	.
cord-285262-690kpupt	318	1	The	the	DT
cord-285262-690kpupt	318	2	viral	viral	JJ
cord-285262-690kpupt	318	3	3C	3c	NN
cord-285262-690kpupt	318	4	protease	protease	NN
cord-285262-690kpupt	318	5	directly	directly	RB
cord-285262-690kpupt	318	6	interacts	interact	VBZ
cord-285262-690kpupt	318	7	and	and	CC
cord-285262-690kpupt	318	8	cleaves	cleave	VBZ
cord-285262-690kpupt	318	9	RIPK1	RIPK1	NNP
cord-285262-690kpupt	318	10	and	and	CC
cord-285262-690kpupt	318	11	blocks	block	VBZ
cord-285262-690kpupt	318	12	necroptosis	necroptosis	NN
cord-285262-690kpupt	318	13	stimulated	stimulate	VBN
cord-285262-690kpupt	318	14	by	by	IN
cord-285262-690kpupt	318	15	Poly(I	Poly(I	NNS
cord-285262-690kpupt	318	16	:	:	:
cord-285262-690kpupt	318	17	C	C	NNP
cord-285262-690kpupt	318	18	)	)	-RRB-
cord-285262-690kpupt	318	19	in	in	IN
cord-285262-690kpupt	318	20	human	human	JJ
cord-285262-690kpupt	318	21	airway	airway	NN
cord-285262-690kpupt	318	22	epithelial	epithelial	JJ
cord-285262-690kpupt	318	23	cells	cell	NNS
cord-285262-690kpupt	318	24	(	(	-LRB-
cord-285262-690kpupt	318	25	L€	l€	CD
cord-285262-690kpupt	318	26	otzerich	otzerich	FW
cord-285262-690kpupt	318	27	et	et	NNP
cord-285262-690kpupt	318	28	al	al	NNP
cord-285262-690kpupt	318	29	.	.	NNP
cord-285262-690kpupt	318	30	,	,	,
cord-285262-690kpupt	318	31	2018	2018	CD
cord-285262-690kpupt	318	32	)	)	-RRB-
cord-285262-690kpupt	318	33	.	.	.
cord-285262-690kpupt	319	1	It	-PRON-	PRP
cord-285262-690kpupt	319	2	is	be	VBZ
cord-285262-690kpupt	319	3	therefore	therefore	RB
cord-285262-690kpupt	319	4	somewhat	somewhat	RB
cord-285262-690kpupt	319	5	surprising	surprising	JJ
cord-285262-690kpupt	319	6	that	that	IN
cord-285262-690kpupt	319	7	the	the	DT
cord-285262-690kpupt	319	8	viral	viral	JJ
cord-285262-690kpupt	319	9	protease	protease	NN
cord-285262-690kpupt	319	10	still	still	RB
cord-285262-690kpupt	319	11	triggers	trigger	VBZ
cord-285262-690kpupt	319	12	a	a	DT
cord-285262-690kpupt	319	13	lytic	lytic	JJ
cord-285262-690kpupt	319	14	cell	cell	NN
cord-285262-690kpupt	319	15	death	death	NN
cord-285262-690kpupt	319	16	pathway	pathway	NN
cord-285262-690kpupt	319	17	,	,	,
cord-285262-690kpupt	319	18	which	which	WDT
cord-285262-690kpupt	319	19	is	be	VBZ
cord-285262-690kpupt	319	20	distinct	distinct	JJ
cord-285262-690kpupt	319	21	from	from	IN
cord-285262-690kpupt	319	22	necroptosis	necroptosis	NN
cord-285262-690kpupt	319	23	and	and	CC
cord-285262-690kpupt	319	24	apoptosis	apoptosis	NN
cord-285262-690kpupt	319	25	.	.	.
cord-285262-690kpupt	320	1	Whereas	whereas	IN
cord-285262-690kpupt	320	2	the	the	DT
cord-285262-690kpupt	320	3	relevance	relevance	NN
cord-285262-690kpupt	320	4	of	of	IN
cord-285262-690kpupt	320	5	necroptosis	necroptosis	NN
cord-285262-690kpupt	320	6	initiation	initiation	NN
cord-285262-690kpupt	320	7	in	in	IN
cord-285262-690kpupt	320	8	viral	viral	JJ
cord-285262-690kpupt	320	9	infection	infection	NN
cord-285262-690kpupt	320	10	has	have	VBZ
cord-285262-690kpupt	320	11	been	be	VBN
cord-285262-690kpupt	320	12	proven	prove	VBN
cord-285262-690kpupt	320	13	only	only	RB
cord-285262-690kpupt	320	14	in	in	IN
cord-285262-690kpupt	320	15	few	few	JJ
cord-285262-690kpupt	320	16	cases	case	NNS
cord-285262-690kpupt	320	17	,	,	,
cord-285262-690kpupt	320	18	for	for	IN
cord-285262-690kpupt	320	19	instance	instance	NN
cord-285262-690kpupt	320	20	in	in	IN
cord-285262-690kpupt	320	21	response	response	NN
cord-285262-690kpupt	320	22	to	to	IN
cord-285262-690kpupt	320	23	IAV	IAV	NNP
cord-285262-690kpupt	320	24	,	,	,
cord-285262-690kpupt	320	25	the	the	DT
cord-285262-690kpupt	320	26	connection	connection	NN
cord-285262-690kpupt	320	27	between	between	IN
cord-285262-690kpupt	320	28	necroptosis	necroptosis	NN
cord-285262-690kpupt	320	29	and	and	CC
cord-285262-690kpupt	320	30	bacterial	bacterial	JJ
cord-285262-690kpupt	320	31	infection	infection	NN
cord-285262-690kpupt	320	32	seems	seem	VBZ
cord-285262-690kpupt	320	33	to	to	TO
cord-285262-690kpupt	320	34	be	be	VB
cord-285262-690kpupt	320	35	more	more	RBR
cord-285262-690kpupt	320	36	obvious	obvious	JJ
cord-285262-690kpupt	320	37	.	.	.
cord-285262-690kpupt	321	1	The	the	DT
cord-285262-690kpupt	321	2	significance	significance	NN
cord-285262-690kpupt	321	3	of	of	IN
cord-285262-690kpupt	321	4	type	type	NN
cord-285262-690kpupt	321	5	I	-PRON-	PRP
cord-285262-690kpupt	321	6	interferons	interferon	NNS
cord-285262-690kpupt	321	7	in	in	IN
cord-285262-690kpupt	321	8	initiating	initiate	VBG
cord-285262-690kpupt	321	9	necroptosis	necroptosis	NNP
cord-285262-690kpupt	321	10	is	be	VBZ
cord-285262-690kpupt	321	11	demonstrated	demonstrate	VBN
cord-285262-690kpupt	321	12	during	during	IN
cord-285262-690kpupt	321	13	Salmonella	Salmonella	NNP
cord-285262-690kpupt	321	14	typhimurium	typhimurium	NN
cord-285262-690kpupt	321	15	infection	infection	NN
cord-285262-690kpupt	321	16	.	.	.
cord-285262-690kpupt	322	1	Mice	mouse	NNS
cord-285262-690kpupt	322	2	deficient	deficient	JJ
cord-285262-690kpupt	322	3	in	in	IN
cord-285262-690kpupt	322	4	the	the	DT
cord-285262-690kpupt	322	5	receptor	receptor	NN
cord-285262-690kpupt	322	6	for	for	IN
cord-285262-690kpupt	322	7	type	type	NN
cord-285262-690kpupt	323	1	I	-PRON-	PRP
cord-285262-690kpupt	323	2	interferons	interferon	NNS
cord-285262-690kpupt	324	1	(	(	-LRB-
cord-285262-690kpupt	324	2	Ifnar1	Ifnar1	NNP
cord-285262-690kpupt	324	3	)	)	-RRB-
cord-285262-690kpupt	324	4	exhibit	exhibit	NN
cord-285262-690kpupt	324	5	improved	improve	VBN
cord-285262-690kpupt	324	6	survival	survival	NN
cord-285262-690kpupt	324	7	,	,	,
cord-285262-690kpupt	324	8	and	and	CC
cord-285262-690kpupt	324	9	macrophages	macrophage	NNS
cord-285262-690kpupt	324	10	derived	derive	VBN
cord-285262-690kpupt	324	11	from	from	IN
cord-285262-690kpupt	324	12	these	these	DT
cord-285262-690kpupt	324	13	mice	mouse	NNS
cord-285262-690kpupt	324	14	exert	exert	VBP
cord-285262-690kpupt	324	15	resistance	resistance	NN
cord-285262-690kpupt	324	16	to	to	IN
cord-285262-690kpupt	324	17	the	the	DT
cord-285262-690kpupt	324	18	bacteria	bacteria	NNS
cord-285262-690kpupt	324	19	triggered	trigger	VBD
cord-285262-690kpupt	324	20	cell	cell	NN
cord-285262-690kpupt	324	21	death	death	NN
cord-285262-690kpupt	324	22	.	.	.
cord-285262-690kpupt	325	1	Consistently	consistently	RB
cord-285262-690kpupt	325	2	,	,	,
cord-285262-690kpupt	325	3	RIPK3	ripk3	NN
cord-285262-690kpupt	325	4	deficient	deficient	JJ
cord-285262-690kpupt	325	5	macrophages	macrophage	NNS
cord-285262-690kpupt	325	6	can	can	MD
cord-285262-690kpupt	325	7	similarly	similarly	RB
cord-285262-690kpupt	325	8	evade	evade	VB
cord-285262-690kpupt	325	9	the	the	DT
cord-285262-690kpupt	325	10	cell	cell	NN
cord-285262-690kpupt	325	11	death	death	NN
cord-285262-690kpupt	325	12	upon	upon	IN
cord-285262-690kpupt	325	13	infection	infection	NN
cord-285262-690kpupt	325	14	.	.	.
cord-285262-690kpupt	326	1	This	this	DT
cord-285262-690kpupt	326	2	study	study	NN
cord-285262-690kpupt	326	3	gives	give	VBZ
cord-285262-690kpupt	326	4	an	an	DT
cord-285262-690kpupt	326	5	example	example	NN
cord-285262-690kpupt	326	6	for	for	IN
cord-285262-690kpupt	326	7	a	a	DT
cord-285262-690kpupt	326	8	necroptosis	necroptosis	NN
cord-285262-690kpupt	326	9	induction	induction	NN
cord-285262-690kpupt	326	10	,	,	,
cord-285262-690kpupt	326	11	which	which	WDT
cord-285262-690kpupt	326	12	is	be	VBZ
cord-285262-690kpupt	326	13	detrimental	detrimental	JJ
cord-285262-690kpupt	326	14	for	for	IN
cord-285262-690kpupt	326	15	the	the	DT
cord-285262-690kpupt	326	16	host	host	NN
cord-285262-690kpupt	326	17	and	and	CC
cord-285262-690kpupt	326	18	beneficial	beneficial	JJ
cord-285262-690kpupt	326	19	for	for	IN
cord-285262-690kpupt	326	20	the	the	DT
cord-285262-690kpupt	326	21	bacteria	bacteria	NNS
cord-285262-690kpupt	326	22	(	(	-LRB-
cord-285262-690kpupt	326	23	Robinson	Robinson	NNP
cord-285262-690kpupt	326	24	et	et	NNP
cord-285262-690kpupt	326	25	al	al	NNP
cord-285262-690kpupt	326	26	.	.	NNP
cord-285262-690kpupt	326	27	,	,	,
cord-285262-690kpupt	326	28	2012	2012	CD
cord-285262-690kpupt	326	29	)	)	-RRB-
cord-285262-690kpupt	326	30	.	.	.
cord-285262-690kpupt	327	1	Similarly	similarly	RB
cord-285262-690kpupt	327	2	,	,	,
cord-285262-690kpupt	327	3	Staphylococcus	Staphylococcus	NNP
cord-285262-690kpupt	327	4	(	(	-LRB-
cord-285262-690kpupt	327	5	S.	S.	NNP
cord-285262-690kpupt	327	6	)	)	-RRB-
cord-285262-690kpupt	327	7	aureus	aureus	NN
cord-285262-690kpupt	327	8	infection	infection	NN
cord-285262-690kpupt	327	9	induced	induce	VBD
cord-285262-690kpupt	327	10	cytotoxicity	cytotoxicity	NN
cord-285262-690kpupt	327	11	can	can	MD
cord-285262-690kpupt	327	12	be	be	VB
cord-285262-690kpupt	327	13	prevented	prevent	VBN
cord-285262-690kpupt	327	14	by	by	IN
cord-285262-690kpupt	327	15	RIPK3	ripk3	NN
cord-285262-690kpupt	327	16	depletion	depletion	NN
cord-285262-690kpupt	327	17	or	or	CC
cord-285262-690kpupt	327	18	inhibition	inhibition	NN
cord-285262-690kpupt	327	19	of	of	IN
cord-285262-690kpupt	327	20	RIPK1	RIPK1	NNP
cord-285262-690kpupt	327	21	and	and	CC
cord-285262-690kpupt	327	22	MLKL	MLKL	NNP
cord-285262-690kpupt	327	23	in	in	IN
cord-285262-690kpupt	327	24	primary	primary	JJ
cord-285262-690kpupt	327	25	human	human	JJ
cord-285262-690kpupt	327	26	macrophages	macrophage	NNS
cord-285262-690kpupt	327	27	.	.	.
cord-285262-690kpupt	328	1	Surprisingly	surprisingly	RB
cord-285262-690kpupt	328	2	,	,	,
cord-285262-690kpupt	328	3	necroptosis	necroptosis	NN
cord-285262-690kpupt	328	4	induction	induction	NN
cord-285262-690kpupt	328	5	by	by	IN
cord-285262-690kpupt	328	6	pore	pore	NN
cord-285262-690kpupt	328	7	forming	form	VBG
cord-285262-690kpupt	328	8	toxins	toxin	NNS
cord-285262-690kpupt	328	9	(	(	-LRB-
cord-285262-690kpupt	328	10	PFT	PFT	NNP
cord-285262-690kpupt	328	11	)	)	-RRB-
cord-285262-690kpupt	328	12	of	of	IN
cord-285262-690kpupt	328	13	S.	S.	NNP
cord-285262-690kpupt	328	14	aureus	aureus	NN
cord-285262-690kpupt	328	15	occurs	occur	VBZ
cord-285262-690kpupt	328	16	without	without	IN
cord-285262-690kpupt	328	17	employing	employ	VBG
cord-285262-690kpupt	328	18	any	any	DT
cord-285262-690kpupt	328	19	external	external	JJ
cord-285262-690kpupt	328	20	caspase	caspase	NN
cord-285262-690kpupt	328	21	inhibition	inhibition	NN
cord-285262-690kpupt	328	22	,	,	,
cord-285262-690kpupt	328	23	which	which	WDT
cord-285262-690kpupt	328	24	suggests	suggest	VBZ
cord-285262-690kpupt	328	25	that	that	IN
cord-285262-690kpupt	328	26	the	the	DT
cord-285262-690kpupt	328	27	caspase-8	caspase-8	NNP
cord-285262-690kpupt	328	28	signal	signal	NN
cord-285262-690kpupt	328	29	remains	remain	VBZ
cord-285262-690kpupt	328	30	inactive	inactive	JJ
cord-285262-690kpupt	328	31	throughout	throughout	IN
cord-285262-690kpupt	328	32	the	the	DT
cord-285262-690kpupt	328	33	whole	whole	JJ
cord-285262-690kpupt	328	34	infection	infection	NN
cord-285262-690kpupt	328	35	process	process	NN
cord-285262-690kpupt	329	1	(	(	-LRB-
cord-285262-690kpupt	329	2	Kitur	Kitur	NNP
cord-285262-690kpupt	329	3	et	et	NNP
cord-285262-690kpupt	329	4	al	al	NNP
cord-285262-690kpupt	329	5	.	.	NNP
cord-285262-690kpupt	329	6	,	,	,
cord-285262-690kpupt	329	7	2015	2015	CD
cord-285262-690kpupt	329	8	)	)	-RRB-
cord-285262-690kpupt	329	9	.	.	.
cord-285262-690kpupt	330	1	In	in	IN
cord-285262-690kpupt	330	2	concordance	concordance	NN
cord-285262-690kpupt	330	3	with	with	IN
cord-285262-690kpupt	330	4	this	this	DT
cord-285262-690kpupt	330	5	,	,	,
cord-285262-690kpupt	330	6	several	several	JJ
cord-285262-690kpupt	330	7	PFT	PFT	NNP
cord-285262-690kpupt	330	8	producing	produce	VBG
cord-285262-690kpupt	330	9	bacterial	bacterial	JJ
cord-285262-690kpupt	330	10	strains	strain	NNS
cord-285262-690kpupt	330	11	,	,	,
cord-285262-690kpupt	330	12	including	include	VBG
cord-285262-690kpupt	330	13	Streptococcus	streptococcus	NN
cord-285262-690kpupt	330	14	pneumoniae	pneumoniae	NN
cord-285262-690kpupt	330	15	and	and	CC
cord-285262-690kpupt	330	16	Staphylococcus	Staphylococcus	NNP
cord-285262-690kpupt	330	17	marcescens	marcescen	NNS
cord-285262-690kpupt	330	18	induce	induce	VBP
cord-285262-690kpupt	330	19	necroptotic	necroptotic	JJ
cord-285262-690kpupt	330	20	cell	cell	NN
cord-285262-690kpupt	330	21	death	death	NN
cord-285262-690kpupt	330	22	in	in	IN
cord-285262-690kpupt	330	23	mouse	mouse	NN
cord-285262-690kpupt	330	24	macrophages	macrophage	NNS
cord-285262-690kpupt	330	25	,	,	,
cord-285262-690kpupt	330	26	which	which	WDT
cord-285262-690kpupt	330	27	can	can	MD
cord-285262-690kpupt	330	28	be	be	VB
cord-285262-690kpupt	330	29	arrested	arrest	VBN
cord-285262-690kpupt	330	30	by	by	IN
cord-285262-690kpupt	330	31	necroptosis	necroptosis	NNP
cord-285262-690kpupt	330	32	inhibitors	inhibitor	NNS
cord-285262-690kpupt	330	33	(	(	-LRB-
cord-285262-690kpupt	330	34	e.g.	e.g.	RB
cord-285262-690kpupt	330	35	,	,	,
cord-285262-690kpupt	330	36	necrostatins	necrostatin	NNS
cord-285262-690kpupt	330	37	)	)	-RRB-
cord-285262-690kpupt	330	38	but	but	CC
cord-285262-690kpupt	330	39	not	not	RB
cord-285262-690kpupt	330	40	by	by	IN
cord-285262-690kpupt	330	41	the	the	DT
cord-285262-690kpupt	330	42	depletion	depletion	NN
cord-285262-690kpupt	330	43	/	/	SYM
cord-285262-690kpupt	330	44	inhibition	inhibition	NN
cord-285262-690kpupt	330	45	of	of	IN
cord-285262-690kpupt	330	46	caspases	caspase	NNS
cord-285262-690kpupt	331	1	(	(	-LRB-
cord-285262-690kpupt	331	2	González	González	NNP
cord-285262-690kpupt	331	3	-	-	HYPH
cord-285262-690kpupt	331	4	Juarbe	Juarbe	NNP
cord-285262-690kpupt	331	5	et	et	NNP
cord-285262-690kpupt	331	6	al	al	NNP
cord-285262-690kpupt	331	7	.	.	NNP
cord-285262-690kpupt	331	8	,	,	,
cord-285262-690kpupt	331	9	2015	2015	CD
cord-285262-690kpupt	331	10	)	)	-RRB-
cord-285262-690kpupt	331	11	.	.	.
cord-285262-690kpupt	332	1	Surprisingly	surprisingly	RB
cord-285262-690kpupt	332	2	,	,	,
cord-285262-690kpupt	332	3	a	a	DT
cord-285262-690kpupt	332	4	PFT	PFT	NNP
cord-285262-690kpupt	332	5	secreted	secrete	VBN
cord-285262-690kpupt	332	6	by	by	IN
cord-285262-690kpupt	332	7	S.	S.	NNP
cord-285262-690kpupt	332	8	marcescens	marcescens	NNP
cord-285262-690kpupt	332	9	can	can	MD
cord-285262-690kpupt	332	10	trigger	trigger	VB
cord-285262-690kpupt	332	11	MLKL	MLKL	NNP
cord-285262-690kpupt	332	12	dependent	dependent	JJ
cord-285262-690kpupt	332	13	necroptosis	necroptosis	NN
cord-285262-690kpupt	332	14	in	in	IN
cord-285262-690kpupt	332	15	mouse	mouse	NN
cord-285262-690kpupt	332	16	lung	lung	NN
cord-285262-690kpupt	332	17	epithelial	epithelial	NN
cord-285262-690kpupt	332	18	cells	cell	NNS
cord-285262-690kpupt	332	19	in	in	IN
cord-285262-690kpupt	332	20	the	the	DT
cord-285262-690kpupt	332	21	absence	absence	NN
cord-285262-690kpupt	332	22	of	of	IN
cord-285262-690kpupt	332	23	TNFR1/2	TNFR1/2	NNP
cord-285262-690kpupt	332	24	or	or	CC
cord-285262-690kpupt	332	25	TLR4	TLR4	NNP
cord-285262-690kpupt	332	26	signaling	signal	VBG
cord-285262-690kpupt	332	27	(	(	-LRB-
cord-285262-690kpupt	332	28	González	González	NNP
cord-285262-690kpupt	332	29	-	-	HYPH
cord-285262-690kpupt	332	30	Juarbe	Juarbe	NNP
cord-285262-690kpupt	332	31	et	et	NNP
cord-285262-690kpupt	332	32	al	al	NNP
cord-285262-690kpupt	332	33	.	.	NNP
cord-285262-690kpupt	332	34	,	,	,
cord-285262-690kpupt	332	35	2017	2017	CD
cord-285262-690kpupt	332	36	)	)	-RRB-
cord-285262-690kpupt	332	37	.	.	.
cord-285262-690kpupt	333	1	Potassium	potassium	NN
cord-285262-690kpupt	333	2	efflux	efflux	NN
cord-285262-690kpupt	333	3	,	,	,
cord-285262-690kpupt	333	4	as	as	IN
cord-285262-690kpupt	333	5	a	a	DT
cord-285262-690kpupt	333	6	key	key	JJ
cord-285262-690kpupt	333	7	event	event	NN
cord-285262-690kpupt	333	8	,	,	,
cord-285262-690kpupt	333	9	has	have	VBZ
cord-285262-690kpupt	333	10	been	be	VBN
cord-285262-690kpupt	333	11	previously	previously	RB
cord-285262-690kpupt	333	12	studied	study	VBN
cord-285262-690kpupt	333	13	in	in	IN
cord-285262-690kpupt	333	14	necroptosis	necroptosis	NNP
cord-285262-690kpupt	333	15	initiation	initiation	NN
cord-285262-690kpupt	333	16	.	.	.
cord-285262-690kpupt	334	1	However	however	RB
cord-285262-690kpupt	334	2	,	,	,
cord-285262-690kpupt	334	3	how	how	WRB
cord-285262-690kpupt	334	4	this	this	DT
cord-285262-690kpupt	334	5	osmotic	osmotic	JJ
cord-285262-690kpupt	334	6	imbalance	imbalance	NN
cord-285262-690kpupt	334	7	orchestrates	orchestrate	VBZ
cord-285262-690kpupt	334	8	the	the	DT
cord-285262-690kpupt	334	9	necroptotic	necroptotic	JJ
cord-285262-690kpupt	334	10	process	process	NN
cord-285262-690kpupt	334	11	still	still	RB
cord-285262-690kpupt	334	12	needs	need	VBZ
cord-285262-690kpupt	334	13	to	to	TO
cord-285262-690kpupt	334	14	be	be	VB
cord-285262-690kpupt	334	15	elucidated	elucidate	VBN
cord-285262-690kpupt	334	16	.	.	.
cord-285262-690kpupt	335	1	An	an	DT
cord-285262-690kpupt	335	2	in	in	IN
cord-285262-690kpupt	335	3	vivo	vivo	NN
cord-285262-690kpupt	335	4	study	study	NN
cord-285262-690kpupt	335	5	describes	describe	VBZ
cord-285262-690kpupt	335	6	the	the	DT
cord-285262-690kpupt	335	7	PFT	PFT	NNP
cord-285262-690kpupt	335	8	driven	drive	VBN
cord-285262-690kpupt	335	9	activation	activation	NN
cord-285262-690kpupt	335	10	of	of	IN
cord-285262-690kpupt	335	11	caspase-2	caspase-2	NNP
cord-285262-690kpupt	335	12	,	,	,
cord-285262-690kpupt	335	13	-4	-4	NNP
cord-285262-690kpupt	335	14	and	and	CC
cord-285262-690kpupt	335	15	-10	-10	NN
cord-285262-690kpupt	335	16	,	,	,
cord-285262-690kpupt	335	17	which	which	WDT
cord-285262-690kpupt	335	18	facilitates	facilitate	VBZ
cord-285262-690kpupt	335	19	the	the	DT
cord-285262-690kpupt	335	20	release	release	NN
cord-285262-690kpupt	335	21	of	of	IN
cord-285262-690kpupt	335	22	alarmins	alarmin	NNS
cord-285262-690kpupt	335	23	to	to	IN
cord-285262-690kpupt	335	24	the	the	DT
cord-285262-690kpupt	335	25	extracellular	extracellular	JJ
cord-285262-690kpupt	335	26	space	space	NN
cord-285262-690kpupt	335	27	.	.	.
cord-285262-690kpupt	336	1	Mycobacterium	mycobacterium	NN
cord-285262-690kpupt	336	2	tuberculosis	tuberculosis	NN
cord-285262-690kpupt	336	3	infection	infection	NN
cord-285262-690kpupt	336	4	induces	induce	VBZ
cord-285262-690kpupt	336	5	NAD+	NAD+	NNP
cord-285262-690kpupt	336	6	depletion	depletion	NN
cord-285262-690kpupt	336	7	triggered	trigger	VBD
cord-285262-690kpupt	336	8	necroptosis	necroptosis	NN
cord-285262-690kpupt	336	9	via	via	IN
cord-285262-690kpupt	336	10	the	the	DT
cord-285262-690kpupt	336	11	RIPK3-MLKL	RIPK3-MLKL	NNP
cord-285262-690kpupt	336	12	axis	axis	NN
cord-285262-690kpupt	336	13	,	,	,
cord-285262-690kpupt	336	14	which	which	WDT
cord-285262-690kpupt	336	15	is	be	VBZ
cord-285262-690kpupt	336	16	initiated	initiate	VBN
cord-285262-690kpupt	336	17	by	by	IN
cord-285262-690kpupt	336	18	the	the	DT
cord-285262-690kpupt	336	19	tuberculosis	tuberculosis	NN
cord-285262-690kpupt	336	20	necrotizing	necrotize	VBG
cord-285262-690kpupt	336	21	toxin	toxin	NN
cord-285262-690kpupt	336	22	(	(	-LRB-
cord-285262-690kpupt	336	23	TNT	TNT	NNP
cord-285262-690kpupt	336	24	)	)	-RRB-
cord-285262-690kpupt	336	25	in	in	IN
cord-285262-690kpupt	336	26	human	human	JJ
cord-285262-690kpupt	336	27	macrophages	macrophage	NNS
cord-285262-690kpupt	336	28	(	(	-LRB-
cord-285262-690kpupt	336	29	Pajuelo	Pajuelo	NNP
cord-285262-690kpupt	336	30	et	et	NNP
cord-285262-690kpupt	336	31	al	al	NNP
cord-285262-690kpupt	336	32	.	.	NNP
cord-285262-690kpupt	336	33	,	,	,
cord-285262-690kpupt	336	34	2018	2018	CD
cord-285262-690kpupt	336	35	)	)	-RRB-
cord-285262-690kpupt	336	36	.	.	.
cord-285262-690kpupt	337	1	In	in	IN
cord-285262-690kpupt	337	2	contrast	contrast	NN
cord-285262-690kpupt	337	3	to	to	IN
cord-285262-690kpupt	337	4	the	the	DT
cord-285262-690kpupt	337	5	observation	observation	NN
cord-285262-690kpupt	337	6	in	in	IN
cord-285262-690kpupt	337	7	human	human	JJ
cord-285262-690kpupt	337	8	macrophages	macrophage	NNS
cord-285262-690kpupt	337	9	,	,	,
cord-285262-690kpupt	337	10	the	the	DT
cord-285262-690kpupt	337	11	pathogenesis	pathogenesis	NN
cord-285262-690kpupt	337	12	of	of	IN
cord-285262-690kpupt	337	13	Mycobacterium	Mycobacterium	NNP
cord-285262-690kpupt	337	14	tuberculosis	tuberculosis	NN
cord-285262-690kpupt	337	15	infection	infection	NN
cord-285262-690kpupt	337	16	is	be	VBZ
cord-285262-690kpupt	337	17	independent	independent	JJ
cord-285262-690kpupt	337	18	from	from	IN
cord-285262-690kpupt	337	19	the	the	DT
cord-285262-690kpupt	337	20	role	role	NN
cord-285262-690kpupt	337	21	of	of	IN
cord-285262-690kpupt	337	22	RIPK3	ripk3	NN
cord-285262-690kpupt	337	23	and	and	CC
cord-285262-690kpupt	337	24	necroptosis	necroptosis	NNP
cord-285262-690kpupt	337	25	in	in	IN
cord-285262-690kpupt	337	26	mice	mouse	NNS
cord-285262-690kpupt	338	1	(	(	-LRB-
cord-285262-690kpupt	338	2	Stutz	Stutz	NNP
cord-285262-690kpupt	338	3	et	et	NNP
cord-285262-690kpupt	338	4	al	al	NNP
cord-285262-690kpupt	338	5	.	.	NNP
cord-285262-690kpupt	338	6	,	,	,
cord-285262-690kpupt	338	7	2018	2018	CD
cord-285262-690kpupt	338	8	)	)	-RRB-
cord-285262-690kpupt	338	9	.	.	.
cord-285262-690kpupt	339	1	Yersinia	Yersinia	NNP
cord-285262-690kpupt	339	2	pestis	pestis	NN
cord-285262-690kpupt	339	3	outer	outer	JJ
cord-285262-690kpupt	339	4	protein	protein	NN
cord-285262-690kpupt	339	5	J	J	NNP
cord-285262-690kpupt	339	6	(	(	-LRB-
cord-285262-690kpupt	339	7	YopJ	YopJ	NNP
cord-285262-690kpupt	339	8	)	)	-RRB-
cord-285262-690kpupt	339	9	is	be	VBZ
cord-285262-690kpupt	339	10	required	require	VBN
cord-285262-690kpupt	339	11	for	for	IN
cord-285262-690kpupt	339	12	the	the	DT
cord-285262-690kpupt	339	13	lymphatic	lymphatic	JJ
cord-285262-690kpupt	339	14	spread	spread	NN
cord-285262-690kpupt	339	15	of	of	IN
cord-285262-690kpupt	339	16	the	the	DT
cord-285262-690kpupt	339	17	bacteria	bacteria	NNS
cord-285262-690kpupt	339	18	,	,	,
cord-285262-690kpupt	339	19	which	which	WDT
cord-285262-690kpupt	339	20	leads	lead	VBZ
cord-285262-690kpupt	339	21	to	to	IN
cord-285262-690kpupt	339	22	the	the	DT
cord-285262-690kpupt	339	23	formation	formation	NN
cord-285262-690kpupt	339	24	of	of	IN
cord-285262-690kpupt	339	25	swollen	swollen	JJ
cord-285262-690kpupt	339	26	and	and	CC
cord-285262-690kpupt	339	27	necrotic	necrotic	JJ
cord-285262-690kpupt	339	28	structures	structure	NNS
cord-285262-690kpupt	339	29	called	call	VBD
cord-285262-690kpupt	339	30	buboes	bubo	NNS
cord-285262-690kpupt	339	31	.	.	.
cord-285262-690kpupt	340	1	YopJ	YopJ	NNP
cord-285262-690kpupt	340	2	suppresses	suppress	VBZ
cord-285262-690kpupt	340	3	the	the	DT
cord-285262-690kpupt	340	4	downregulators	downregulator	NNS
cord-285262-690kpupt	340	5	of	of	IN
cord-285262-690kpupt	340	6	the	the	DT
cord-285262-690kpupt	340	7	RIPK1	RIPK1	NNP
cord-285262-690kpupt	340	8	driven	drive	VBN
cord-285262-690kpupt	340	9	necroptosis	necroptosis	NNP
cord-285262-690kpupt	340	10	,	,	,
cord-285262-690kpupt	340	11	resulting	result	VBG
cord-285262-690kpupt	340	12	in	in	IN
cord-285262-690kpupt	340	13	necroptotic	necroptotic	JJ
cord-285262-690kpupt	340	14	spread	spread	NN
cord-285262-690kpupt	340	15	of	of	IN
cord-285262-690kpupt	340	16	the	the	DT
cord-285262-690kpupt	340	17	pathogen	pathogen	NN
cord-285262-690kpupt	340	18	.	.	.
cord-285262-690kpupt	341	1	In	in	IN
cord-285262-690kpupt	341	2	concordance	concordance	NN
cord-285262-690kpupt	341	3	with	with	IN
cord-285262-690kpupt	341	4	this	this	DT
cord-285262-690kpupt	341	5	,	,	,
cord-285262-690kpupt	341	6	necrostatin	necrostatin	NNP
cord-285262-690kpupt	341	7	treatment	treatment	NN
cord-285262-690kpupt	341	8	efficiently	efficiently	RB
cord-285262-690kpupt	341	9	protects	protect	VBZ
cord-285262-690kpupt	341	10	the	the	DT
cord-285262-690kpupt	341	11	mice	mouse	NNS
cord-285262-690kpupt	341	12	from	from	IN
cord-285262-690kpupt	341	13	lethal	lethal	JJ
cord-285262-690kpupt	341	14	infections	infection	NNS
cord-285262-690kpupt	341	15	of	of	IN
cord-285262-690kpupt	341	16	the	the	DT
cord-285262-690kpupt	341	17	bacteria	bacteria	NNS
cord-285262-690kpupt	342	1	(	(	-LRB-
cord-285262-690kpupt	342	2	Arifuzzaman	Arifuzzaman	NNP
cord-285262-690kpupt	342	3	et	et	NNP
cord-285262-690kpupt	342	4	al	al	NNP
cord-285262-690kpupt	342	5	.	.	NNP
cord-285262-690kpupt	342	6	,	,	,
cord-285262-690kpupt	342	7	2018	2018	CD
cord-285262-690kpupt	342	8	)	)	-RRB-
cord-285262-690kpupt	342	9	.	.	.
cord-285262-690kpupt	343	1	It	-PRON-	PRP
cord-285262-690kpupt	343	2	is	be	VBZ
cord-285262-690kpupt	343	3	demonstrated	demonstrate	VBN
cord-285262-690kpupt	343	4	that	that	IN
cord-285262-690kpupt	343	5	YopJ	YopJ	NNP
cord-285262-690kpupt	343	6	interferes	interfere	VBZ
cord-285262-690kpupt	343	7	with	with	IN
cord-285262-690kpupt	343	8	the	the	DT
cord-285262-690kpupt	343	9	pro	pro	JJ
cord-285262-690kpupt	343	10	-	-	JJ
cord-285262-690kpupt	343	11	survival	survival	JJ
cord-285262-690kpupt	343	12	activity	activity	NN
cord-285262-690kpupt	343	13	of	of	IN
cord-285262-690kpupt	343	14	the	the	DT
cord-285262-690kpupt	343	15	FLIPs	flip	NNS
cord-285262-690kpupt	343	16	in	in	IN
cord-285262-690kpupt	343	17	the	the	DT
cord-285262-690kpupt	343	18	DISC	disc	NN
cord-285262-690kpupt	343	19	,	,	,
cord-285262-690kpupt	343	20	thereby	thereby	RB
cord-285262-690kpupt	343	21	promoting	promote	VBG
cord-285262-690kpupt	343	22	the	the	DT
cord-285262-690kpupt	343	23	necroptotic	necroptotic	JJ
cord-285262-690kpupt	343	24	feature	feature	NN
cord-285262-690kpupt	343	25	of	of	IN
cord-285262-690kpupt	343	26	the	the	DT
cord-285262-690kpupt	343	27	RIPKs	ripks	NN
cord-285262-690kpupt	343	28	.	.	.
cord-285262-690kpupt	344	1	In	in	IN
cord-285262-690kpupt	344	2	contrast	contrast	NN
cord-285262-690kpupt	344	3	to	to	IN
cord-285262-690kpupt	344	4	the	the	DT
cord-285262-690kpupt	344	5	previous	previous	JJ
cord-285262-690kpupt	344	6	examples	example	NNS
cord-285262-690kpupt	344	7	,	,	,
cord-285262-690kpupt	344	8	some	some	DT
cord-285262-690kpupt	344	9	bacteria	bacteria	NNS
cord-285262-690kpupt	344	10	have	have	VBP
cord-285262-690kpupt	344	11	developed	develop	VBN
cord-285262-690kpupt	344	12	countermeasures	countermeasure	NNS
cord-285262-690kpupt	344	13	to	to	TO
cord-285262-690kpupt	344	14	inhibit	inhibit	VB
cord-285262-690kpupt	344	15	the	the	DT
cord-285262-690kpupt	344	16	necroptotic	necroptotic	JJ
cord-285262-690kpupt	344	17	signals	signal	NNS
cord-285262-690kpupt	344	18	of	of	IN
cord-285262-690kpupt	344	19	the	the	DT
cord-285262-690kpupt	344	20	host	host	NN
cord-285262-690kpupt	344	21	.	.	.
cord-285262-690kpupt	345	1	The	the	DT
cord-285262-690kpupt	345	2	enterophatogenic	enterophatogenic	JJ
cord-285262-690kpupt	345	3	E.	E.	NNP
cord-285262-690kpupt	345	4	coli	coli	NNS
cord-285262-690kpupt	345	5	(	(	-LRB-
cord-285262-690kpupt	345	6	EPEC	EPEC	NNP
cord-285262-690kpupt	345	7	)	)	-RRB-
cord-285262-690kpupt	345	8	directly	directly	RB
cord-285262-690kpupt	345	9	interferes	interfere	VBZ
cord-285262-690kpupt	345	10	with	with	IN
cord-285262-690kpupt	345	11	the	the	DT
cord-285262-690kpupt	345	12	elements	element	NNS
cord-285262-690kpupt	345	13	of	of	IN
cord-285262-690kpupt	345	14	the	the	DT
cord-285262-690kpupt	345	15	necroptotic	necroptotic	JJ
cord-285262-690kpupt	345	16	signal	signal	NN
cord-285262-690kpupt	345	17	transduction	transduction	NN
cord-285262-690kpupt	345	18	.	.	.
cord-285262-690kpupt	346	1	Espl	Espl	NNP
cord-285262-690kpupt	346	2	,	,	,
cord-285262-690kpupt	346	3	an	an	DT
cord-285262-690kpupt	346	4	effector	effector	NN
cord-285262-690kpupt	346	5	component	component	NN
cord-285262-690kpupt	346	6	of	of	IN
cord-285262-690kpupt	346	7	the	the	DT
cord-285262-690kpupt	346	8	EPEC	EPEC	NNP
cord-285262-690kpupt	346	9	T3SS	T3SS	NNP
cord-285262-690kpupt	346	10	is	be	VBZ
cord-285262-690kpupt	346	11	identified	identify	VBN
cord-285262-690kpupt	346	12	as	as	IN
cord-285262-690kpupt	346	13	a	a	DT
cord-285262-690kpupt	346	14	protease	protease	NN
cord-285262-690kpupt	346	15	,	,	,
cord-285262-690kpupt	346	16	that	that	WDT
cord-285262-690kpupt	346	17	can	can	MD
cord-285262-690kpupt	346	18	target	target	VB
cord-285262-690kpupt	346	19	and	and	CC
cord-285262-690kpupt	346	20	cleave	cleave	VB
cord-285262-690kpupt	346	21	host	host	NN
cord-285262-690kpupt	346	22	proteins	protein	NNS
cord-285262-690kpupt	346	23	containing	contain	VBG
cord-285262-690kpupt	346	24	a	a	DT
cord-285262-690kpupt	346	25	RHIM	RHIM	NNP
cord-285262-690kpupt	346	26	domain	domain	NN
cord-285262-690kpupt	346	27	,	,	,
cord-285262-690kpupt	346	28	including	include	VBG
cord-285262-690kpupt	346	29	RIPK1/3	ripk1/3	NN
cord-285262-690kpupt	346	30	,	,	,
cord-285262-690kpupt	346	31	TRIF	TRIF	NNP
cord-285262-690kpupt	346	32	and	and	CC
cord-285262-690kpupt	346	33	ZBP1	ZBP1	NNP
cord-285262-690kpupt	347	1	(	(	-LRB-
cord-285262-690kpupt	347	2	Pearson	Pearson	NNP
cord-285262-690kpupt	347	3	et	et	NNP
cord-285262-690kpupt	347	4	al	al	NNP
cord-285262-690kpupt	347	5	.	.	NNP
cord-285262-690kpupt	347	6	,	,	,
cord-285262-690kpupt	347	7	2017	2017	CD
cord-285262-690kpupt	347	8	)	)	-RRB-
cord-285262-690kpupt	347	9	.	.	.
cord-285262-690kpupt	348	1	Further	further	JJ
cord-285262-690kpupt	348	2	example	example	NN
cord-285262-690kpupt	348	3	for	for	IN
cord-285262-690kpupt	348	4	necroptosis	necroptosis	NNP
cord-285262-690kpupt	348	5	inhibition	inhibition	NN
cord-285262-690kpupt	348	6	is	be	VBZ
cord-285262-690kpupt	348	7	demonstrated	demonstrate	VBN
cord-285262-690kpupt	348	8	in	in	IN
cord-285262-690kpupt	348	9	a	a	DT
cord-285262-690kpupt	348	10	study	study	NN
cord-285262-690kpupt	348	11	employing	employ	VBG
cord-285262-690kpupt	348	12	the	the	DT
cord-285262-690kpupt	348	13	Salmonella	Salmonella	NNP
cord-285262-690kpupt	348	14	induced	induce	VBN
cord-285262-690kpupt	348	15	colitis	colitis	NN
cord-285262-690kpupt	348	16	model	model	NN
cord-285262-690kpupt	348	17	.	.	.
cord-285262-690kpupt	349	1	The	the	DT
cord-285262-690kpupt	349	2	salmonella	salmonella	NN
cord-285262-690kpupt	349	3	outer	outer	JJ
cord-285262-690kpupt	349	4	protein	protein	NN
cord-285262-690kpupt	349	5	B	B	NNP
cord-285262-690kpupt	349	6	(	(	-LRB-
cord-285262-690kpupt	349	7	SopB	SopB	NNP
cord-285262-690kpupt	349	8	)	)	-RRB-
cord-285262-690kpupt	349	9	attenuates	attenuate	VBZ
cord-285262-690kpupt	349	10	the	the	DT
cord-285262-690kpupt	349	11	necroptotic	necroptotic	JJ
cord-285262-690kpupt	349	12	cell	cell	NN
cord-285262-690kpupt	349	13	death	death	NN
cord-285262-690kpupt	349	14	by	by	IN
cord-285262-690kpupt	349	15	decreasing	decrease	VBG
cord-285262-690kpupt	349	16	the	the	DT
cord-285262-690kpupt	349	17	level	level	NN
cord-285262-690kpupt	349	18	of	of	IN
cord-285262-690kpupt	349	19	MLKL	MLKL	NNP
cord-285262-690kpupt	349	20	phosphorylation	phosphorylation	NN
cord-285262-690kpupt	349	21	in	in	IN
cord-285262-690kpupt	349	22	the	the	DT
cord-285262-690kpupt	349	23	cells	cell	NNS
cord-285262-690kpupt	349	24	(	(	-LRB-
cord-285262-690kpupt	349	25	Hu	Hu	NNP
cord-285262-690kpupt	349	26	et	et	FW
cord-285262-690kpupt	349	27	al	al	NNP
cord-285262-690kpupt	349	28	.	.	NNP
cord-285262-690kpupt	349	29	,	,	,
cord-285262-690kpupt	349	30	2019	2019	CD
cord-285262-690kpupt	349	31	)	)	-RRB-
cord-285262-690kpupt	349	32	.	.	.
cord-285262-690kpupt	350	1	TLR-3	TLR-3	NNP
cord-285262-690kpupt	350	2	and	and	CC
cord-285262-690kpupt	350	3	TLR-4	TLR-4	NNP
cord-285262-690kpupt	350	4	are	be	VBP
cord-285262-690kpupt	350	5	PAMP	PAMP	NNP
cord-285262-690kpupt	350	6	recognition	recognition	NN
cord-285262-690kpupt	350	7	receptors	receptor	NNS
cord-285262-690kpupt	350	8	and	and	CC
cord-285262-690kpupt	350	9	engage	engage	VBP
cord-285262-690kpupt	350	10	dsRNA	dsrna	NN
cord-285262-690kpupt	350	11	and	and	CC
cord-285262-690kpupt	350	12	bacterial	bacterial	JJ
cord-285262-690kpupt	350	13	lipopolysaccharide	lipopolysaccharide	NN
cord-285262-690kpupt	350	14	(	(	-LRB-
cord-285262-690kpupt	350	15	LPS	LPS	NNP
cord-285262-690kpupt	350	16	)	)	-RRB-
cord-285262-690kpupt	350	17	,	,	,
cord-285262-690kpupt	350	18	respectively	respectively	RB
cord-285262-690kpupt	350	19	,	,	,
cord-285262-690kpupt	350	20	which	which	WDT
cord-285262-690kpupt	350	21	in	in	IN
cord-285262-690kpupt	350	22	turn	turn	NN
cord-285262-690kpupt	350	23	initiate	initiate	VBP
cord-285262-690kpupt	350	24	the	the	DT
cord-285262-690kpupt	350	25	recruitment	recruitment	NN
cord-285262-690kpupt	350	26	of	of	IN
cord-285262-690kpupt	350	27	Toll	Toll	NNP
cord-285262-690kpupt	350	28	/	/	SYM
cord-285262-690kpupt	350	29	IL-1R	IL-1R	NNP
cord-285262-690kpupt	350	30	(	(	-LRB-
cord-285262-690kpupt	350	31	TIR	TIR	NNP
cord-285262-690kpupt	350	32	)	)	-RRB-
cord-285262-690kpupt	350	33	domain	domain	NN
cord-285262-690kpupt	350	34	containing	contain	VBG
cord-285262-690kpupt	350	35	adapters	adapter	NNS
cord-285262-690kpupt	350	36	to	to	TO
cord-285262-690kpupt	350	37	activate	activate	VB
cord-285262-690kpupt	350	38	gene	gene	NN
cord-285262-690kpupt	350	39	expression	expression	NN
cord-285262-690kpupt	350	40	via	via	IN
cord-285262-690kpupt	350	41	transcription	transcription	NN
cord-285262-690kpupt	350	42	factors	factor	NNS
cord-285262-690kpupt	350	43	,	,	,
cord-285262-690kpupt	350	44	such	such	JJ
cord-285262-690kpupt	350	45	as	as	IN
cord-285262-690kpupt	350	46	NF	nf	NN
cord-285262-690kpupt	350	47	-	-	HYPH
cord-285262-690kpupt	350	48	κB	κB	NNP
cord-285262-690kpupt	351	1	and	and	CC
cord-285262-690kpupt	351	2	IRF3/7	IRF3/7	NNP
cord-285262-690kpupt	351	3	.	.	.
cord-285262-690kpupt	352	1	Over	over	IN
cord-285262-690kpupt	352	2	the	the	DT
cord-285262-690kpupt	352	3	last	last	JJ
cord-285262-690kpupt	352	4	years	year	NNS
cord-285262-690kpupt	352	5	,	,	,
cord-285262-690kpupt	352	6	the	the	DT
cord-285262-690kpupt	352	7	role	role	NN
cord-285262-690kpupt	352	8	of	of	IN
cord-285262-690kpupt	352	9	TLR	TLR	NNP
cord-285262-690kpupt	352	10	receptors	receptor	NNS
cord-285262-690kpupt	352	11	in	in	IN
cord-285262-690kpupt	352	12	mediating	mediate	VBG
cord-285262-690kpupt	352	13	cell	cell	NN
cord-285262-690kpupt	352	14	death	death	NN
cord-285262-690kpupt	352	15	pathways	pathway	NNS
cord-285262-690kpupt	352	16	has	have	VBZ
cord-285262-690kpupt	352	17	been	be	VBN
cord-285262-690kpupt	352	18	intensively	intensively	RB
cord-285262-690kpupt	352	19	studied	study	VBN
cord-285262-690kpupt	352	20	.	.	.
cord-285262-690kpupt	353	1	Induction	induction	NN
cord-285262-690kpupt	353	2	of	of	IN
cord-285262-690kpupt	353	3	TLRs	tlr	NNS
cord-285262-690kpupt	353	4	can	can	MD
cord-285262-690kpupt	353	5	induce	induce	VB
cord-285262-690kpupt	353	6	caspase-8	caspase-8	NNP
cord-285262-690kpupt	353	7	activation	activation	NN
cord-285262-690kpupt	353	8	(	(	-LRB-
cord-285262-690kpupt	353	9	Kaiser	Kaiser	NNP
cord-285262-690kpupt	353	10	and	and	CC
cord-285262-690kpupt	353	11	Offermann	Offermann	NNP
cord-285262-690kpupt	353	12	,	,	,
cord-285262-690kpupt	353	13	2005	2005	CD
cord-285262-690kpupt	353	14	)	)	-RRB-
cord-285262-690kpupt	353	15	and	and	CC
cord-285262-690kpupt	354	1	the	the	DT
cord-285262-690kpupt	354	2	inhibition	inhibition	NN
cord-285262-690kpupt	354	3	of	of	IN
cord-285262-690kpupt	354	4	caspase-8	caspase-8	JJ
cord-285262-690kpupt	354	5	activity	activity	NN
cord-285262-690kpupt	354	6	leads	lead	VBZ
cord-285262-690kpupt	354	7	to	to	IN
cord-285262-690kpupt	354	8	a	a	DT
cord-285262-690kpupt	354	9	RIPK3	ripk3	NN
cord-285262-690kpupt	354	10	dependent	dependent	JJ
cord-285262-690kpupt	354	11	necrotic	necrotic	JJ
cord-285262-690kpupt	354	12	-	-	HYPH
cord-285262-690kpupt	354	13	like	like	JJ
cord-285262-690kpupt	354	14	cell	cell	NN
cord-285262-690kpupt	354	15	death	death	NN
cord-285262-690kpupt	354	16	in	in	IN
cord-285262-690kpupt	354	17	mouse	mouse	NN
cord-285262-690kpupt	354	18	macrophages	macrophage	NNS
cord-285262-690kpupt	354	19	.	.	.
cord-285262-690kpupt	355	1	The	the	DT
cord-285262-690kpupt	355	2	adaptor	adaptor	NN
cord-285262-690kpupt	355	3	protein	protein	NN
cord-285262-690kpupt	355	4	TRIF	TRIF	NNP
cord-285262-690kpupt	355	5	is	be	VBZ
cord-285262-690kpupt	355	6	necessary	necessary	JJ
cord-285262-690kpupt	355	7	to	to	TO
cord-285262-690kpupt	355	8	transduce	transduce	VB
cord-285262-690kpupt	355	9	signals	signal	NNS
cord-285262-690kpupt	355	10	from	from	IN
cord-285262-690kpupt	355	11	TLR3	TLR3	NNP
cord-285262-690kpupt	355	12	stimulation	stimulation	NN
cord-285262-690kpupt	355	13	,	,	,
cord-285262-690kpupt	355	14	whereas	whereas	IN
cord-285262-690kpupt	355	15	activation	activation	NN
cord-285262-690kpupt	355	16	of	of	IN
cord-285262-690kpupt	355	17	TLR4	TLR4	NNP
cord-285262-690kpupt	355	18	can	can	MD
cord-285262-690kpupt	355	19	engage	engage	VB
cord-285262-690kpupt	355	20	both	both	DT
cord-285262-690kpupt	355	21	TRIF	TRIF	NNP
cord-285262-690kpupt	355	22	and	and	CC
cord-285262-690kpupt	355	23	MyD88	MyD88	NNP
cord-285262-690kpupt	355	24	.	.	.
cord-285262-690kpupt	356	1	These	these	DT
cord-285262-690kpupt	356	2	pathways	pathway	NNS
cord-285262-690kpupt	356	3	proceed	proceed	VBP
cord-285262-690kpupt	356	4	independent	independent	JJ
cord-285262-690kpupt	356	5	of	of	IN
cord-285262-690kpupt	356	6	RIPK1	RIPK1	NNP
cord-285262-690kpupt	356	7	in	in	IN
cord-285262-690kpupt	356	8	mouse	mouse	NN
cord-285262-690kpupt	356	9	fibroblasts	fibroblast	NNS
cord-285262-690kpupt	356	10	,	,	,
cord-285262-690kpupt	356	11	but	but	CC
cord-285262-690kpupt	356	12	can	can	MD
cord-285262-690kpupt	356	13	efficiently	efficiently	RB
cord-285262-690kpupt	356	14	trigger	trigger	VB
cord-285262-690kpupt	356	15	MLKL	MLKL	NNP
cord-285262-690kpupt	356	16	activation	activation	NN
cord-285262-690kpupt	356	17	downstream	downstream	NN
cord-285262-690kpupt	356	18	of	of	IN
cord-285262-690kpupt	356	19	RIPK3	ripk3	NN
cord-285262-690kpupt	357	1	(	(	-LRB-
cord-285262-690kpupt	357	2	Kaiser	Kaiser	NNP
cord-285262-690kpupt	357	3	et	et	NNP
cord-285262-690kpupt	357	4	al	al	NNP
cord-285262-690kpupt	357	5	.	.	NNP
cord-285262-690kpupt	357	6	,	,	,
cord-285262-690kpupt	357	7	2013	2013	CD
cord-285262-690kpupt	357	8	)	)	-RRB-
cord-285262-690kpupt	358	1	(	(	-LRB-
cord-285262-690kpupt	358	2	Fig	Fig	NNP
cord-285262-690kpupt	358	3	.	.	NNP
cord-285262-690kpupt	358	4	2	2	CD
cord-285262-690kpupt	358	5	)	)	-RRB-
cord-285262-690kpupt	358	6	.	.	.
cord-285262-690kpupt	359	1	In	in	IN
cord-285262-690kpupt	359	2	response	response	NN
cord-285262-690kpupt	359	3	to	to	IN
cord-285262-690kpupt	359	4	TNFR	TNFR	NNP
cord-285262-690kpupt	359	5	ligation	ligation	NNP
cord-285262-690kpupt	359	6	,	,	,
cord-285262-690kpupt	359	7	the	the	DT
cord-285262-690kpupt	359	8	ubiquitination	ubiquitination	JJ
cord-285262-690kpupt	359	9	status	status	NN
cord-285262-690kpupt	359	10	of	of	IN
cord-285262-690kpupt	359	11	RIPK1	RIPK1	NNP
cord-285262-690kpupt	359	12	is	be	VBZ
cord-285262-690kpupt	359	13	defined	define	VBN
cord-285262-690kpupt	359	14	as	as	IN
cord-285262-690kpupt	359	15	the	the	DT
cord-285262-690kpupt	359	16	key	key	JJ
cord-285262-690kpupt	359	17	factor	factor	NN
cord-285262-690kpupt	359	18	in	in	IN
cord-285262-690kpupt	359	19	the	the	DT
cord-285262-690kpupt	359	20	decision	decision	NN
cord-285262-690kpupt	359	21	making	make	VBG
cord-285262-690kpupt	359	22	between	between	IN
cord-285262-690kpupt	359	23	survival	survival	NN
cord-285262-690kpupt	359	24	and	and	CC
cord-285262-690kpupt	359	25	death	death	NN
cord-285262-690kpupt	359	26	.	.	.
cord-285262-690kpupt	360	1	Upon	upon	IN
cord-285262-690kpupt	360	2	TNF	TNF	NNP
cord-285262-690kpupt	360	3	stimulation	stimulation	NN
cord-285262-690kpupt	360	4	,	,	,
cord-285262-690kpupt	360	5	the	the	DT
cord-285262-690kpupt	360	6	activated	activate	VBN
cord-285262-690kpupt	360	7	caspase-8	caspase-8	NNP
cord-285262-690kpupt	360	8	cleaves	cleave	VBZ
cord-285262-690kpupt	360	9	CYLD	CYLD	NNP
cord-285262-690kpupt	360	10	,	,	,
cord-285262-690kpupt	360	11	the	the	DT
cord-285262-690kpupt	360	12	deubiquitinase	deubiquitinase	NN
cord-285262-690kpupt	360	13	enzyme	enzyme	NN
cord-285262-690kpupt	360	14	of	of	IN
cord-285262-690kpupt	360	15	RIPK1	RIPK1	NNP
cord-285262-690kpupt	361	1	(	(	-LRB-
cord-285262-690kpupt	361	2	O'Donnell	O'Donnell	NNP
cord-285262-690kpupt	361	3	et	et	NNP
cord-285262-690kpupt	361	4	al	al	NNP
cord-285262-690kpupt	361	5	.	.	NNP
cord-285262-690kpupt	361	6	,	,	,
cord-285262-690kpupt	361	7	2011	2011	CD
cord-285262-690kpupt	361	8	)	)	-RRB-
cord-285262-690kpupt	361	9	.	.	.
cord-285262-690kpupt	362	1	The	the	DT
cord-285262-690kpupt	362	2	LPS	LPS	NNP
cord-285262-690kpupt	362	3	induced	induce	VBD
cord-285262-690kpupt	362	4	TLR-4	TLR-4	NNP
cord-285262-690kpupt	362	5	ligation	ligation	NN
cord-285262-690kpupt	362	6	recruits	recruit	VBZ
cord-285262-690kpupt	362	7	FADD	FADD	NNP
cord-285262-690kpupt	362	8	and	and	CC
cord-285262-690kpupt	362	9	caspase-8	caspase-8	NNP
cord-285262-690kpupt	362	10	in	in	IN
cord-285262-690kpupt	362	11	a	a	DT
cord-285262-690kpupt	362	12	complex	complex	NN
cord-285262-690kpupt	362	13	and	and	CC
cord-285262-690kpupt	362	14	initiates	initiate	VBZ
cord-285262-690kpupt	362	15	the	the	DT
cord-285262-690kpupt	362	16	cleavage	cleavage	NN
cord-285262-690kpupt	362	17	of	of	IN
cord-285262-690kpupt	362	18	CYLD	CYLD	NNP
cord-285262-690kpupt	362	19	(	(	-LRB-
cord-285262-690kpupt	362	20	Legarda	Legarda	NNP
cord-285262-690kpupt	362	21	et	et	NNP
cord-285262-690kpupt	362	22	al	al	NNP
cord-285262-690kpupt	362	23	.	.	NNP
cord-285262-690kpupt	362	24	,	,	,
cord-285262-690kpupt	362	25	2016	2016	CD
cord-285262-690kpupt	362	26	)	)	-RRB-
cord-285262-690kpupt	362	27	.	.	.
cord-285262-690kpupt	363	1	The	the	DT
cord-285262-690kpupt	363	2	non	non	JJ
cord-285262-690kpupt	363	3	-	-	JJ
cord-285262-690kpupt	363	4	histone	histone	JJ
cord-285262-690kpupt	363	5	chromatin	chromatin	NN
cord-285262-690kpupt	363	6	binding	bind	VBG
cord-285262-690kpupt	363	7	protein	protein	NN
cord-285262-690kpupt	363	8	high	high	JJ
cord-285262-690kpupt	363	9	mobility	mobility	NN
cord-285262-690kpupt	363	10	group	group	NN
cord-285262-690kpupt	363	11	box-1	box-1	NNP
cord-285262-690kpupt	363	12	(	(	-LRB-
cord-285262-690kpupt	363	13	HMGB1	HMGB1	NNP
cord-285262-690kpupt	363	14	)	)	-RRB-
cord-285262-690kpupt	363	15	is	be	VBZ
cord-285262-690kpupt	363	16	released	release	VBN
cord-285262-690kpupt	363	17	into	into	IN
cord-285262-690kpupt	363	18	the	the	DT
cord-285262-690kpupt	363	19	extracellular	extracellular	JJ
cord-285262-690kpupt	363	20	space	space	NN
cord-285262-690kpupt	363	21	(	(	-LRB-
cord-285262-690kpupt	363	22	Lu	Lu	NNP
cord-285262-690kpupt	363	23	et	et	FW
cord-285262-690kpupt	363	24	al	al	NNP
cord-285262-690kpupt	363	25	.	.	NNP
cord-285262-690kpupt	363	26	,	,	,
cord-285262-690kpupt	363	27	2012	2012	CD
cord-285262-690kpupt	363	28	)	)	-RRB-
cord-285262-690kpupt	363	29	during	during	IN
cord-285262-690kpupt	363	30	necroptosis	necroptosis	NNP
cord-285262-690kpupt	363	31	and	and	CC
cord-285262-690kpupt	363	32	functions	function	NNS
cord-285262-690kpupt	363	33	as	as	IN
cord-285262-690kpupt	363	34	a	a	DT
cord-285262-690kpupt	363	35	pro	pro	JJ
cord-285262-690kpupt	363	36	-	-	JJ
cord-285262-690kpupt	363	37	inflammatory	inflammatory	JJ
cord-285262-690kpupt	363	38	DAMP	damp	NN
cord-285262-690kpupt	364	1	(	(	-LRB-
cord-285262-690kpupt	364	2	Scaffidi	Scaffidi	NNP
cord-285262-690kpupt	364	3	et	et	NNP
cord-285262-690kpupt	364	4	al	al	NNP
cord-285262-690kpupt	364	5	.	.	NNP
cord-285262-690kpupt	364	6	,	,	,
cord-285262-690kpupt	364	7	2002	2002	CD
cord-285262-690kpupt	364	8	)	)	-RRB-
cord-285262-690kpupt	364	9	.	.	.
cord-285262-690kpupt	365	1	Interestingly	interestingly	RB
cord-285262-690kpupt	365	2	,	,	,
cord-285262-690kpupt	365	3	HMGB1	HMGB1	NNP
cord-285262-690kpupt	365	4	can	can	MD
cord-285262-690kpupt	365	5	form	form	VB
cord-285262-690kpupt	365	6	a	a	DT
cord-285262-690kpupt	365	7	complex	complex	NN
cord-285262-690kpupt	365	8	with	with	IN
cord-285262-690kpupt	365	9	LPS	lp	NNS
cord-285262-690kpupt	365	10	upon	upon	IN
cord-285262-690kpupt	365	11	infection	infection	NN
cord-285262-690kpupt	365	12	,	,	,
cord-285262-690kpupt	365	13	which	which	WDT
cord-285262-690kpupt	365	14	leads	lead	VBZ
cord-285262-690kpupt	365	15	to	to	IN
cord-285262-690kpupt	365	16	an	an	DT
cord-285262-690kpupt	365	17	amplified	amplify	VBN
cord-285262-690kpupt	365	18	activation	activation	NN
cord-285262-690kpupt	365	19	of	of	IN
cord-285262-690kpupt	365	20	TRIF	TRIF	NNP
cord-285262-690kpupt	365	21	dependent	dependent	JJ
cord-285262-690kpupt	365	22	immune	immune	JJ
cord-285262-690kpupt	365	23	responses	response	NNS
cord-285262-690kpupt	365	24	.	.	.
cord-285262-690kpupt	366	1	Pyroptosis	Pyroptosis	NNP
cord-285262-690kpupt	366	2	is	be	VBZ
cord-285262-690kpupt	366	3	an	an	DT
cord-285262-690kpupt	366	4	inflammatory	inflammatory	JJ
cord-285262-690kpupt	366	5	and	and	CC
cord-285262-690kpupt	366	6	regulated	regulated	JJ
cord-285262-690kpupt	366	7	cell	cell	NN
cord-285262-690kpupt	366	8	death	death	NN
cord-285262-690kpupt	366	9	modality	modality	NN
cord-285262-690kpupt	366	10	(	(	-LRB-
cord-285262-690kpupt	366	11	Fink	Fink	NNP
cord-285262-690kpupt	366	12	and	and	CC
cord-285262-690kpupt	366	13	Cookson	Cookson	NNP
cord-285262-690kpupt	366	14	,	,	,
cord-285262-690kpupt	366	15	2006	2006	CD
cord-285262-690kpupt	366	16	)	)	-RRB-
cord-285262-690kpupt	366	17	that	that	WDT
cord-285262-690kpupt	366	18	partially	partially	RB
cord-285262-690kpupt	366	19	shares	share	VBZ
cord-285262-690kpupt	366	20	features	feature	VBZ
cord-285262-690kpupt	366	21	with	with	IN
cord-285262-690kpupt	366	22	apoptosis	apoptosis	NN
cord-285262-690kpupt	366	23	,	,	,
cord-285262-690kpupt	366	24	because	because	IN
cord-285262-690kpupt	366	25	it	-PRON-	PRP
cord-285262-690kpupt	366	26	requires	require	VBZ
cord-285262-690kpupt	366	27	caspase	caspase	NN
cord-285262-690kpupt	366	28	activation	activation	NN
cord-285262-690kpupt	366	29	.	.	.
cord-285262-690kpupt	367	1	On	on	IN
cord-285262-690kpupt	367	2	the	the	DT
cord-285262-690kpupt	367	3	other	other	JJ
cord-285262-690kpupt	367	4	hand	hand	NN
cord-285262-690kpupt	367	5	,	,	,
cord-285262-690kpupt	367	6	the	the	DT
cord-285262-690kpupt	367	7	pyroptotic	pyroptotic	NN
cord-285262-690kpupt	367	8	membrane	membrane	NN
cord-285262-690kpupt	367	9	rupture	rupture	NN
cord-285262-690kpupt	367	10	occurs	occur	VBZ
cord-285262-690kpupt	367	11	rapidly	rapidly	RB
cord-285262-690kpupt	367	12	in	in	IN
cord-285262-690kpupt	367	13	the	the	DT
cord-285262-690kpupt	367	14	affected	affected	JJ
cord-285262-690kpupt	367	15	cells	cell	NNS
cord-285262-690kpupt	367	16	,	,	,
cord-285262-690kpupt	367	17	which	which	WDT
cord-285262-690kpupt	367	18	is	be	VBZ
cord-285262-690kpupt	367	19	a	a	DT
cord-285262-690kpupt	367	20	common	common	JJ
cord-285262-690kpupt	367	21	feature	feature	NN
cord-285262-690kpupt	367	22	shared	share	VBN
cord-285262-690kpupt	367	23	with	with	IN
cord-285262-690kpupt	367	24	necroptosis	necroptosis	NNP
cord-285262-690kpupt	367	25	.	.	.
cord-285262-690kpupt	368	1	Pyroptosis	Pyroptosis	NNP
cord-285262-690kpupt	368	2	has	have	VBZ
cord-285262-690kpupt	368	3	been	be	VBN
cord-285262-690kpupt	368	4	observed	observe	VBN
cord-285262-690kpupt	368	5	in	in	IN
cord-285262-690kpupt	368	6	monocytes	monocyte	NNS
cord-285262-690kpupt	368	7	,	,	,
cord-285262-690kpupt	368	8	macrophages	macrophage	NNS
cord-285262-690kpupt	368	9	,	,	,
cord-285262-690kpupt	368	10	dendritic	dendritic	JJ
cord-285262-690kpupt	368	11	cells	cell	NNS
cord-285262-690kpupt	368	12	,	,	,
cord-285262-690kpupt	368	13	lymphocytes	lymphocyte	NNS
cord-285262-690kpupt	368	14	,	,	,
cord-285262-690kpupt	368	15	epithelial	epithelial	JJ
cord-285262-690kpupt	368	16	cells	cell	NNS
cord-285262-690kpupt	368	17	,	,	,
cord-285262-690kpupt	368	18	and	and	CC
cord-285262-690kpupt	368	19	endothelial	endothelial	JJ
cord-285262-690kpupt	368	20	cells	cell	NNS
cord-285262-690kpupt	368	21	(	(	-LRB-
cord-285262-690kpupt	369	1	Man	Man	NNP
cord-285262-690kpupt	369	2	et	et	NNP
cord-285262-690kpupt	369	3	al	al	NNP
cord-285262-690kpupt	369	4	.	.	NNP
cord-285262-690kpupt	369	5	,	,	,
cord-285262-690kpupt	369	6	2017	2017	CD
cord-285262-690kpupt	369	7	)	)	-RRB-
cord-285262-690kpupt	369	8	.	.	.
cord-285262-690kpupt	370	1	Contrary	contrary	JJ
cord-285262-690kpupt	370	2	to	to	IN
cord-285262-690kpupt	370	3	apoptosis	apoptosis	NN
cord-285262-690kpupt	370	4	,	,	,
cord-285262-690kpupt	370	5	induction	induction	NN
cord-285262-690kpupt	370	6	of	of	IN
cord-285262-690kpupt	370	7	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	370	8	activates	activate	VBZ
cord-285262-690kpupt	370	9	inflammatory	inflammatory	JJ
cord-285262-690kpupt	370	10	caspases	caspase	NNS
cord-285262-690kpupt	370	11	,	,	,
cord-285262-690kpupt	370	12	which	which	WDT
cord-285262-690kpupt	370	13	,	,	,
cord-285262-690kpupt	370	14	similarly	similarly	RB
cord-285262-690kpupt	370	15	to	to	IN
cord-285262-690kpupt	370	16	apoptotic	apoptotic	JJ
cord-285262-690kpupt	370	17	initiator	initiator	NN
cord-285262-690kpupt	370	18	caspases	caspase	NNS
cord-285262-690kpupt	370	19	,	,	,
cord-285262-690kpupt	370	20	possess	possess	VBP
cord-285262-690kpupt	370	21	a	a	DT
cord-285262-690kpupt	370	22	large	large	JJ
cord-285262-690kpupt	370	23	prodomain	prodomain	NN
cord-285262-690kpupt	370	24	structure	structure	NN
cord-285262-690kpupt	370	25	.	.	.
cord-285262-690kpupt	371	1	The	the	DT
cord-285262-690kpupt	371	2	inflammatory	inflammatory	JJ
cord-285262-690kpupt	371	3	caspase-1	caspase-1	NNP
cord-285262-690kpupt	371	4	,	,	,
cord-285262-690kpupt	371	5	caspase-4/5	caspase-4/5	VBP
cord-285262-690kpupt	371	6	in	in	IN
cord-285262-690kpupt	371	7	humans	human	NNS
cord-285262-690kpupt	371	8	and	and	CC
cord-285262-690kpupt	371	9	caspase-11	caspase-11	NNS
cord-285262-690kpupt	371	10	in	in	IN
cord-285262-690kpupt	371	11	mice	mouse	NNS
cord-285262-690kpupt	371	12	are	be	VBP
cord-285262-690kpupt	371	13	being	be	VBG
cord-285262-690kpupt	371	14	activated	activate	VBN
cord-285262-690kpupt	371	15	in	in	IN
cord-285262-690kpupt	371	16	large	large	JJ
cord-285262-690kpupt	371	17	molecular	molecular	JJ
cord-285262-690kpupt	371	18	weight	weight	NN
cord-285262-690kpupt	371	19	complexes	complex	NNS
cord-285262-690kpupt	371	20	,	,	,
cord-285262-690kpupt	371	21	termed	term	VBN
cord-285262-690kpupt	371	22	inflammasomes	inflammasome	NNS
cord-285262-690kpupt	371	23	(	(	-LRB-
cord-285262-690kpupt	371	24	van	van	NNP
cord-285262-690kpupt	371	25	Opdenbosch	Opdenbosch	NNP
cord-285262-690kpupt	371	26	and	and	CC
cord-285262-690kpupt	371	27	Lamkanfi	Lamkanfi	NNP
cord-285262-690kpupt	371	28	,	,	,
cord-285262-690kpupt	371	29	2019	2019	CD
cord-285262-690kpupt	371	30	)	)	-RRB-
cord-285262-690kpupt	371	31	.	.	.
cord-285262-690kpupt	372	1	In	in	IN
cord-285262-690kpupt	372	2	general	general	JJ
cord-285262-690kpupt	372	3	,	,	,
cord-285262-690kpupt	372	4	inflammasomes	inflammasome	NNS
cord-285262-690kpupt	372	5	consist	consist	VBP
cord-285262-690kpupt	372	6	of	of	IN
cord-285262-690kpupt	372	7	sensors	sensor	NNS
cord-285262-690kpupt	372	8	that	that	WDT
cord-285262-690kpupt	372	9	can	can	MD
cord-285262-690kpupt	372	10	recognize	recognize	VB
cord-285262-690kpupt	372	11	pathogenic	pathogenic	JJ
cord-285262-690kpupt	372	12	insults	insult	NNS
cord-285262-690kpupt	372	13	,	,	,
cord-285262-690kpupt	372	14	also	also	RB
cord-285262-690kpupt	372	15	termed	term	VBN
cord-285262-690kpupt	372	16	PAMPs	pamp	NNS
cord-285262-690kpupt	372	17	.	.	.
cord-285262-690kpupt	373	1	Depending	depend	VBG
cord-285262-690kpupt	373	2	on	on	IN
cord-285262-690kpupt	373	3	the	the	DT
cord-285262-690kpupt	373	4	nature	nature	NN
cord-285262-690kpupt	373	5	of	of	IN
cord-285262-690kpupt	373	6	a	a	DT
cord-285262-690kpupt	373	7	PAMP	PAMP	NNP
cord-285262-690kpupt	373	8	signal	signal	NN
cord-285262-690kpupt	373	9	,	,	,
cord-285262-690kpupt	373	10	different	different	JJ
cord-285262-690kpupt	373	11	sensors	sensor	NNS
cord-285262-690kpupt	373	12	are	be	VBP
cord-285262-690kpupt	373	13	triggered	trigger	VBN
cord-285262-690kpupt	373	14	.	.	.
cord-285262-690kpupt	374	1	The	the	DT
cord-285262-690kpupt	374	2	nucleotide	nucleotide	JJ
cord-285262-690kpupt	374	3	binding	bind	VBG
cord-285262-690kpupt	374	4	oligomerization	oligomerization	NN
cord-285262-690kpupt	374	5	domain	domain	NN
cord-285262-690kpupt	374	6	(	(	-LRB-
cord-285262-690kpupt	374	7	NOD)like	nod)like	IN
cord-285262-690kpupt	374	8	receptors	receptor	NNS
cord-285262-690kpupt	374	9	represent	represent	VBP
cord-285262-690kpupt	374	10	the	the	DT
cord-285262-690kpupt	374	11	best	well	RBS
cord-285262-690kpupt	374	12	studied	study	VBN
cord-285262-690kpupt	374	13	inflammasome	inflammasome	NN
cord-285262-690kpupt	374	14	components	component	NNS
cord-285262-690kpupt	374	15	,	,	,
cord-285262-690kpupt	374	16	that	that	WDT
cord-285262-690kpupt	374	17	recognize	recognize	VBP
cord-285262-690kpupt	374	18	PAMPs	pamp	NNS
cord-285262-690kpupt	374	19	(	(	-LRB-
cord-285262-690kpupt	374	20	Fig	fig	NN
cord-285262-690kpupt	374	21	.	.	.
cord-285262-690kpupt	374	22	3	3	CD
cord-285262-690kpupt	374	23	)	)	-RRB-
cord-285262-690kpupt	374	24	,	,	,
cord-285262-690kpupt	374	25	but	but	CC
cord-285262-690kpupt	374	26	various	various	JJ
cord-285262-690kpupt	374	27	other	other	JJ
cord-285262-690kpupt	374	28	PAMP	PAMP	NNP
cord-285262-690kpupt	374	29	receptors	receptor	NNS
cord-285262-690kpupt	374	30	have	have	VBP
cord-285262-690kpupt	374	31	also	also	RB
cord-285262-690kpupt	374	32	been	be	VBN
cord-285262-690kpupt	374	33	identified	identify	VBN
cord-285262-690kpupt	374	34	in	in	IN
cord-285262-690kpupt	374	35	the	the	DT
cord-285262-690kpupt	374	36	last	last	JJ
cord-285262-690kpupt	374	37	years	year	NNS
cord-285262-690kpupt	374	38	.	.	.
cord-285262-690kpupt	375	1	These	these	DT
cord-285262-690kpupt	375	2	pathogen	pathogen	NN
cord-285262-690kpupt	375	3	sensors	sensor	NNS
cord-285262-690kpupt	375	4	can	can	MD
cord-285262-690kpupt	375	5	recruit	recruit	VB
cord-285262-690kpupt	375	6	caspases	caspase	NNS
cord-285262-690kpupt	375	7	either	either	CC
cord-285262-690kpupt	375	8	directly	directly	RB
cord-285262-690kpupt	375	9	or	or	CC
cord-285262-690kpupt	375	10	via	via	IN
cord-285262-690kpupt	375	11	an	an	DT
cord-285262-690kpupt	375	12	adaptor	adaptor	NN
cord-285262-690kpupt	375	13	molecule	molecule	NN
cord-285262-690kpupt	375	14	.	.	.
cord-285262-690kpupt	376	1	Once	once	RB
cord-285262-690kpupt	376	2	,	,	,
cord-285262-690kpupt	376	3	the	the	DT
cord-285262-690kpupt	376	4	inflammatory	inflammatory	JJ
cord-285262-690kpupt	376	5	caspase-1	caspase-1	NNP
cord-285262-690kpupt	376	6	is	be	VBZ
cord-285262-690kpupt	376	7	activated	activate	VBN
cord-285262-690kpupt	376	8	,	,	,
cord-285262-690kpupt	376	9	it	-PRON-	PRP
cord-285262-690kpupt	376	10	can	can	MD
cord-285262-690kpupt	376	11	process	process	VB
cord-285262-690kpupt	376	12	interleukin	interleukin	NN
cord-285262-690kpupt	376	13	(	(	-LRB-
cord-285262-690kpupt	376	14	IL	IL	NNP
cord-285262-690kpupt	376	15	)	)	-RRB-
cord-285262-690kpupt	376	16	1β	1β	NNS
cord-285262-690kpupt	376	17	and	and	CC
cord-285262-690kpupt	376	18	18	18	CD
cord-285262-690kpupt	376	19	into	into	IN
cord-285262-690kpupt	376	20	their	-PRON-	PRP$
cord-285262-690kpupt	376	21	mature	mature	JJ
cord-285262-690kpupt	376	22	forms	form	NNS
cord-285262-690kpupt	376	23	.	.	.
cord-285262-690kpupt	377	1	Furthermore	furthermore	RB
cord-285262-690kpupt	377	2	,	,	,
cord-285262-690kpupt	377	3	both	both	CC
cord-285262-690kpupt	377	4	caspase-1	caspase-1	NNP
cord-285262-690kpupt	377	5	and	and	CC
cord-285262-690kpupt	377	6	caspase-11	caspase-11	NNP
cord-285262-690kpupt	377	7	can	can	MD
cord-285262-690kpupt	377	8	process	process	VB
cord-285262-690kpupt	377	9	gasdermin	gasdermin	NN
cord-285262-690kpupt	377	10	-	-	HYPH
cord-285262-690kpupt	377	11	D	d	JJ
cord-285262-690kpupt	377	12	(	(	-LRB-
cord-285262-690kpupt	377	13	GSDMD	GSDMD	NNP
cord-285262-690kpupt	377	14	)	)	-RRB-
cord-285262-690kpupt	377	15	,	,	,
cord-285262-690kpupt	377	16	a	a	DT
cord-285262-690kpupt	377	17	member	member	NN
cord-285262-690kpupt	377	18	of	of	IN
cord-285262-690kpupt	377	19	the	the	DT
cord-285262-690kpupt	377	20	less	less	RBR
cord-285262-690kpupt	377	21	studied	study	VBN
cord-285262-690kpupt	377	22	gasdermin	gasdermin	NNP
cord-285262-690kpupt	377	23	protein	protein	NN
cord-285262-690kpupt	377	24	family	family	NN
cord-285262-690kpupt	377	25	(	(	-LRB-
cord-285262-690kpupt	377	26	Kayagaki	Kayagaki	NNP
cord-285262-690kpupt	377	27	et	et	NNP
cord-285262-690kpupt	377	28	al	al	NNP
cord-285262-690kpupt	377	29	.	.	NNP
cord-285262-690kpupt	377	30	,	,	,
cord-285262-690kpupt	377	31	2015	2015	CD
cord-285262-690kpupt	377	32	)	)	-RRB-
cord-285262-690kpupt	377	33	.	.	.
cord-285262-690kpupt	378	1	The	the	DT
cord-285262-690kpupt	378	2	N	n	CD
cord-285262-690kpupt	378	3	-	-	HYPH
cord-285262-690kpupt	378	4	terminal	terminal	NN
cord-285262-690kpupt	378	5	leaflet	leaflet	NN
cord-285262-690kpupt	378	6	of	of	IN
cord-285262-690kpupt	378	7	GSDMD	GSDMD	NNP
cord-285262-690kpupt	378	8	inserts	insert	NNS
cord-285262-690kpupt	378	9	into	into	IN
cord-285262-690kpupt	378	10	the	the	DT
cord-285262-690kpupt	378	11	lipid	lipid	NN
cord-285262-690kpupt	378	12	bilayer	bilayer	NN
cord-285262-690kpupt	378	13	and	and	CC
cord-285262-690kpupt	378	14	forms	form	VBZ
cord-285262-690kpupt	378	15	oligomer	oligomer	NNP
cord-285262-690kpupt	378	16	pores	pore	NNS
cord-285262-690kpupt	378	17	with	with	IN
cord-285262-690kpupt	378	18	an	an	DT
cord-285262-690kpupt	378	19	inner	inner	JJ
cord-285262-690kpupt	378	20	diameter	diameter	NN
cord-285262-690kpupt	378	21	of	of	IN
cord-285262-690kpupt	378	22	approximately	approximately	RB
cord-285262-690kpupt	378	23	20	20	CD
cord-285262-690kpupt	378	24	nm	nm	NN
cord-285262-690kpupt	379	1	(	(	-LRB-
cord-285262-690kpupt	379	2	Sborgi	Sborgi	NNP
cord-285262-690kpupt	379	3	et	et	NNP
cord-285262-690kpupt	379	4	al	al	NNP
cord-285262-690kpupt	379	5	.	.	NNP
cord-285262-690kpupt	379	6	,	,	,
cord-285262-690kpupt	379	7	2016	2016	CD
cord-285262-690kpupt	379	8	)	)	-RRB-
cord-285262-690kpupt	379	9	,	,	,
cord-285262-690kpupt	379	10	leading	lead	VBG
cord-285262-690kpupt	379	11	to	to	IN
cord-285262-690kpupt	379	12	IL-1β/-18	IL-1β/-18	NNP
cord-285262-690kpupt	379	13	release	release	NN
cord-285262-690kpupt	379	14	(	(	-LRB-
cord-285262-690kpupt	379	15	He	-PRON-	PRP
cord-285262-690kpupt	379	16	et	et	FW
cord-285262-690kpupt	379	17	al	al	NNP
cord-285262-690kpupt	379	18	.	.	NNP
cord-285262-690kpupt	379	19	,	,	,
cord-285262-690kpupt	379	20	2015	2015	CD
cord-285262-690kpupt	379	21	)	)	-RRB-
cord-285262-690kpupt	379	22	and	and	CC
cord-285262-690kpupt	379	23	to	to	IN
cord-285262-690kpupt	379	24	osmotic	osmotic	JJ
cord-285262-690kpupt	379	25	imbalance	imbalance	NN
cord-285262-690kpupt	379	26	driven	drive	VBN
cord-285262-690kpupt	379	27	swelling	swelling	NN
cord-285262-690kpupt	379	28	of	of	IN
cord-285262-690kpupt	379	29	the	the	DT
cord-285262-690kpupt	379	30	cells	cell	NNS
cord-285262-690kpupt	379	31	(	(	-LRB-
cord-285262-690kpupt	379	32	Fig	fig	NN
cord-285262-690kpupt	379	33	.	.	.
cord-285262-690kpupt	379	34	3	3	CD
cord-285262-690kpupt	379	35	)	)	-RRB-
cord-285262-690kpupt	379	36	.	.	.
cord-285262-690kpupt	380	1	Several	several	JJ
cord-285262-690kpupt	380	2	studies	study	NNS
cord-285262-690kpupt	380	3	conclude	conclude	VBP
cord-285262-690kpupt	380	4	the	the	DT
cord-285262-690kpupt	380	5	role	role	NN
cord-285262-690kpupt	380	6	of	of	IN
cord-285262-690kpupt	380	7	GSDMD	GSDMD	NNP
cord-285262-690kpupt	380	8	as	as	IN
cord-285262-690kpupt	380	9	a	a	DT
cord-285262-690kpupt	380	10	key	key	JJ
cord-285262-690kpupt	380	11	factor	factor	NN
cord-285262-690kpupt	380	12	for	for	IN
cord-285262-690kpupt	380	13	IL	IL	NNP
cord-285262-690kpupt	380	14	secretion	secretion	NN
cord-285262-690kpupt	380	15	.	.	.
cord-285262-690kpupt	381	1	In	in	IN
cord-285262-690kpupt	381	2	this	this	DT
cord-285262-690kpupt	381	3	setup	setup	NN
cord-285262-690kpupt	381	4	,	,	,
cord-285262-690kpupt	381	5	the	the	DT
cord-285262-690kpupt	381	6	pyroptotic	pyroptotic	JJ
cord-285262-690kpupt	381	7	membrane	membrane	NN
cord-285262-690kpupt	381	8	integrity	integrity	NN
cord-285262-690kpupt	381	9	loss	loss	NN
cord-285262-690kpupt	381	10	,	,	,
cord-285262-690kpupt	381	11	the	the	DT
cord-285262-690kpupt	381	12	swelling	swelling	NN
cord-285262-690kpupt	381	13	and	and	CC
cord-285262-690kpupt	381	14	the	the	DT
cord-285262-690kpupt	381	15	cell	cell	NN
cord-285262-690kpupt	381	16	death	death	NN
cord-285262-690kpupt	381	17	are	be	VBP
cord-285262-690kpupt	381	18	interpreted	interpret	VBN
cord-285262-690kpupt	381	19	as	as	IN
cord-285262-690kpupt	381	20	the	the	DT
cord-285262-690kpupt	381	21	collateral	collateral	JJ
cord-285262-690kpupt	381	22	damage	damage	NN
cord-285262-690kpupt	381	23	of	of	IN
cord-285262-690kpupt	381	24	the	the	DT
cord-285262-690kpupt	381	25	pore	pore	NN
cord-285262-690kpupt	381	26	formation	formation	NN
cord-285262-690kpupt	381	27	.	.	.
cord-285262-690kpupt	382	1	In	in	IN
cord-285262-690kpupt	382	2	fact	fact	NN
cord-285262-690kpupt	382	3	,	,	,
cord-285262-690kpupt	382	4	GSDMD	GSDMD	NNP
cord-285262-690kpupt	382	5	driven	drive	VBN
cord-285262-690kpupt	382	6	IL	IL	NNP
cord-285262-690kpupt	382	7	release	release	NN
cord-285262-690kpupt	382	8	can	can	MD
cord-285262-690kpupt	382	9	proceed	proceed	VB
cord-285262-690kpupt	382	10	without	without	IN
cord-285262-690kpupt	382	11	any	any	DT
cord-285262-690kpupt	382	12	cell	cell	NN
cord-285262-690kpupt	382	13	destruction	destruction	NN
cord-285262-690kpupt	382	14	(	(	-LRB-
cord-285262-690kpupt	382	15	Evavold	Evavold	NNP
cord-285262-690kpupt	382	16	et	et	NNP
cord-285262-690kpupt	382	17	al	al	NNP
cord-285262-690kpupt	382	18	.	.	NNP
cord-285262-690kpupt	382	19	,	,	,
cord-285262-690kpupt	382	20	2018	2018	CD
cord-285262-690kpupt	382	21	)	)	-RRB-
cord-285262-690kpupt	382	22	.	.	.
cord-285262-690kpupt	383	1	In	in	IN
cord-285262-690kpupt	383	2	contrast	contrast	NN
cord-285262-690kpupt	383	3	,	,	,
cord-285262-690kpupt	383	4	a	a	DT
cord-285262-690kpupt	383	5	recent	recent	JJ
cord-285262-690kpupt	383	6	study	study	NN
cord-285262-690kpupt	383	7	on	on	IN
cord-285262-690kpupt	383	8	mice	mouse	NNS
cord-285262-690kpupt	383	9	infected	infect	VBN
cord-285262-690kpupt	383	10	with	with	IN
cord-285262-690kpupt	383	11	Burkholderia	Burkholderia	NNP
cord-285262-690kpupt	383	12	thailandensis	thailandensis	NN
cord-285262-690kpupt	383	13	leads	lead	VBZ
cord-285262-690kpupt	383	14	to	to	IN
cord-285262-690kpupt	383	15	the	the	DT
cord-285262-690kpupt	383	16	conclusion	conclusion	NN
cord-285262-690kpupt	383	17	that	that	IN
cord-285262-690kpupt	383	18	the	the	DT
cord-285262-690kpupt	383	19	action	action	NN
cord-285262-690kpupt	383	20	of	of	IN
cord-285262-690kpupt	383	21	GSDMD	GSDMD	NNP
cord-285262-690kpupt	383	22	on	on	IN
cord-285262-690kpupt	383	23	bacterial	bacterial	JJ
cord-285262-690kpupt	383	24	killing	killing	NN
cord-285262-690kpupt	383	25	occurs	occur	VBZ
cord-285262-690kpupt	383	26	in	in	IN
cord-285262-690kpupt	383	27	a	a	DT
cord-285262-690kpupt	383	28	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	383	29	dependent	dependent	JJ
cord-285262-690kpupt	383	30	manner	manner	NN
cord-285262-690kpupt	384	1	Fig	Fig	NNP
cord-285262-690kpupt	384	2	.	.	.
cord-285262-690kpupt	385	1	3	3	LS
cord-285262-690kpupt	386	1	Inflammasome	Inflammasome	NNP
cord-285262-690kpupt	386	2	activation	activation	NN
cord-285262-690kpupt	386	3	and	and	CC
cord-285262-690kpupt	386	4	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	386	5	signaling	signaling	NN
cord-285262-690kpupt	386	6	.	.	.
cord-285262-690kpupt	387	1	Components	component	NNS
cord-285262-690kpupt	387	2	of	of	IN
cord-285262-690kpupt	387	3	the	the	DT
cord-285262-690kpupt	387	4	bacterial	bacterial	JJ
cord-285262-690kpupt	387	5	T3SS	t3ss	NN
cord-285262-690kpupt	387	6	and	and	CC
cord-285262-690kpupt	387	7	bacterial	bacterial	JJ
cord-285262-690kpupt	387	8	flagellins	flagellin	NNS
cord-285262-690kpupt	387	9	can	can	MD
cord-285262-690kpupt	387	10	activate	activate	VB
cord-285262-690kpupt	387	11	the	the	DT
cord-285262-690kpupt	387	12	NAIPs	naip	NNS
cord-285262-690kpupt	387	13	.	.	.
cord-285262-690kpupt	388	1	In	in	IN
cord-285262-690kpupt	388	2	turn	turn	NN
cord-285262-690kpupt	388	3	,	,	,
cord-285262-690kpupt	388	4	NAIPs	naip	NNS
cord-285262-690kpupt	388	5	stimulate	stimulate	VBP
cord-285262-690kpupt	388	6	the	the	DT
cord-285262-690kpupt	388	7	NLRC-4	NLRC-4	NNP
cord-285262-690kpupt	388	8	inflammasome	inflammasome	NN
cord-285262-690kpupt	388	9	(	(	-LRB-
cord-285262-690kpupt	388	10	top	top	JJ
cord-285262-690kpupt	388	11	left	left	JJ
cord-285262-690kpupt	388	12	)	)	-RRB-
cord-285262-690kpupt	388	13	,	,	,
cord-285262-690kpupt	388	14	leading	lead	VBG
cord-285262-690kpupt	388	15	to	to	IN
cord-285262-690kpupt	388	16	caspase-1	caspase-1	NNP
cord-285262-690kpupt	388	17	activation	activation	NN
cord-285262-690kpupt	388	18	.	.	.
cord-285262-690kpupt	389	1	Anthrax	anthrax	NN
cord-285262-690kpupt	389	2	lethal	lethal	JJ
cord-285262-690kpupt	389	3	toxin	toxin	NN
cord-285262-690kpupt	389	4	(	(	-LRB-
cord-285262-690kpupt	389	5	top	top	JJ
cord-285262-690kpupt	389	6	middle	middle	JJ
cord-285262-690kpupt	389	7	)	)	-RRB-
cord-285262-690kpupt	389	8	directly	directly	RB
cord-285262-690kpupt	389	9	interacts	interact	VBZ
cord-285262-690kpupt	389	10	with	with	IN
cord-285262-690kpupt	389	11	NLRP1b	nlrp1b	NN
cord-285262-690kpupt	389	12	and	and	CC
cord-285262-690kpupt	389	13	triggers	trigger	VBZ
cord-285262-690kpupt	389	14	the	the	DT
cord-285262-690kpupt	389	15	recruitment	recruitment	NN
cord-285262-690kpupt	389	16	of	of	IN
cord-285262-690kpupt	389	17	ASC	ASC	NNP
cord-285262-690kpupt	389	18	.	.	.
cord-285262-690kpupt	390	1	Intracellular	Intracellular	NNP
cord-285262-690kpupt	390	2	perturbations	perturbation	NNS
cord-285262-690kpupt	390	3	culminating	culminate	VBG
cord-285262-690kpupt	390	4	in	in	IN
cord-285262-690kpupt	390	5	potassium	potassium	NN
cord-285262-690kpupt	390	6	efflux	efflux	NN
cord-285262-690kpupt	390	7	stimulate	stimulate	VBP
cord-285262-690kpupt	390	8	the	the	DT
cord-285262-690kpupt	390	9	assembly	assembly	NN
cord-285262-690kpupt	390	10	of	of	IN
cord-285262-690kpupt	390	11	the	the	DT
cord-285262-690kpupt	390	12	NLRP3	NLRP3	NNP
cord-285262-690kpupt	390	13	inflammasome	inflammasome	NNP
cord-285262-690kpupt	390	14	(	(	-LRB-
cord-285262-690kpupt	390	15	top	top	JJ
cord-285262-690kpupt	390	16	right	right	NN
cord-285262-690kpupt	390	17	)	)	-RRB-
cord-285262-690kpupt	390	18	,	,	,
cord-285262-690kpupt	390	19	leading	lead	VBG
cord-285262-690kpupt	390	20	to	to	IN
cord-285262-690kpupt	390	21	the	the	DT
cord-285262-690kpupt	390	22	recruitment	recruitment	NN
cord-285262-690kpupt	390	23	of	of	IN
cord-285262-690kpupt	390	24	the	the	DT
cord-285262-690kpupt	390	25	adaptor	adaptor	NN
cord-285262-690kpupt	390	26	protein	protein	NN
cord-285262-690kpupt	390	27	ASC	ASC	NNP
cord-285262-690kpupt	390	28	.	.	.
cord-285262-690kpupt	391	1	NLRP3	NLRP3	NNP
cord-285262-690kpupt	391	2	requires	require	VBZ
cord-285262-690kpupt	391	3	priming	prime	VBG
cord-285262-690kpupt	391	4	signals	signal	NNS
cord-285262-690kpupt	391	5	via	via	IN
cord-285262-690kpupt	391	6	the	the	DT
cord-285262-690kpupt	391	7	ligation	ligation	NN
cord-285262-690kpupt	391	8	of	of	IN
cord-285262-690kpupt	391	9	TNF	TNF	NNP
cord-285262-690kpupt	391	10	or	or	CC
cord-285262-690kpupt	391	11	TLRs	TLRs	NNP
cord-285262-690kpupt	391	12	.	.	.
cord-285262-690kpupt	392	1	The	the	DT
cord-285262-690kpupt	392	2	IFN	IFN	NNP
cord-285262-690kpupt	392	3	-	-	HYPH
cord-285262-690kpupt	392	4	stimulated	stimulate	VBN
cord-285262-690kpupt	392	5	GBPs	GBPs	NNPS
cord-285262-690kpupt	392	6	facilitate	facilitate	VBP
cord-285262-690kpupt	392	7	the	the	DT
cord-285262-690kpupt	392	8	release	release	NN
cord-285262-690kpupt	392	9	of	of	IN
cord-285262-690kpupt	392	10	the	the	DT
cord-285262-690kpupt	392	11	pathogenic	pathogenic	JJ
cord-285262-690kpupt	392	12	DNA	dna	NN
cord-285262-690kpupt	392	13	fragments	fragment	NNS
cord-285262-690kpupt	392	14	into	into	IN
cord-285262-690kpupt	392	15	the	the	DT
cord-285262-690kpupt	392	16	cytosol	cytosol	NN
cord-285262-690kpupt	392	17	,	,	,
cord-285262-690kpupt	392	18	which	which	WDT
cord-285262-690kpupt	392	19	in	in	IN
cord-285262-690kpupt	392	20	turn	turn	NN
cord-285262-690kpupt	392	21	can	can	MD
cord-285262-690kpupt	392	22	stimulate	stimulate	VB
cord-285262-690kpupt	392	23	the	the	DT
cord-285262-690kpupt	392	24	AIM2	AIM2	NNP
cord-285262-690kpupt	392	25	inflammasome	inflammasome	NN
cord-285262-690kpupt	392	26	.	.	.
cord-285262-690kpupt	393	1	Caspase-11	Caspase-11	NNP
cord-285262-690kpupt	393	2	and	and	CC
cord-285262-690kpupt	393	3	caspase-4/5	caspase-4/5	NN
cord-285262-690kpupt	393	4	(	(	-LRB-
cord-285262-690kpupt	393	5	left	left	JJ
cord-285262-690kpupt	393	6	)	)	-RRB-
cord-285262-690kpupt	393	7	can	can	MD
cord-285262-690kpupt	393	8	directly	directly	RB
cord-285262-690kpupt	393	9	detect	detect	VB
cord-285262-690kpupt	393	10	LPS	LPS	NNP
cord-285262-690kpupt	393	11	,	,	,
cord-285262-690kpupt	393	12	released	release	VBN
cord-285262-690kpupt	393	13	by	by	IN
cord-285262-690kpupt	393	14	the	the	DT
cord-285262-690kpupt	393	15	GBPs	GBPs	NNPS
cord-285262-690kpupt	393	16	into	into	IN
cord-285262-690kpupt	393	17	the	the	DT
cord-285262-690kpupt	393	18	cytosol	cytosol	NN
cord-285262-690kpupt	393	19	.	.	.
cord-285262-690kpupt	394	1	Active	active	JJ
cord-285262-690kpupt	394	2	caspase-1	caspase-1	NNP
cord-285262-690kpupt	394	3	can	can	MD
cord-285262-690kpupt	394	4	process	process	VB
cord-285262-690kpupt	394	5	pro	pro	JJ
cord-285262-690kpupt	394	6	-	-	JJ
cord-285262-690kpupt	394	7	IL1β	IL1β	NNP
cord-285262-690kpupt	394	8	/	/	SYM
cord-285262-690kpupt	394	9	IL18	IL18	NNP
cord-285262-690kpupt	394	10	and	and	CC
cord-285262-690kpupt	394	11	cleave	cleave	VB
cord-285262-690kpupt	394	12	GSDMD	GSDMD	NNP
cord-285262-690kpupt	394	13	,	,	,
cord-285262-690kpupt	394	14	subsequently	subsequently	RB
cord-285262-690kpupt	394	15	leading	lead	VBG
cord-285262-690kpupt	394	16	to	to	IN
cord-285262-690kpupt	394	17	GSDMD	GSDMD	NNP
cord-285262-690kpupt	394	18	pore	pore	NN
cord-285262-690kpupt	394	19	formation	formation	NN
cord-285262-690kpupt	394	20	and	and	CC
cord-285262-690kpupt	394	21	release	release	NN
cord-285262-690kpupt	394	22	of	of	IN
cord-285262-690kpupt	394	23	the	the	DT
cord-285262-690kpupt	394	24	ILs	il	NNS
cord-285262-690kpupt	394	25	into	into	IN
cord-285262-690kpupt	394	26	the	the	DT
cord-285262-690kpupt	394	27	extracellular	extracellular	JJ
cord-285262-690kpupt	394	28	space	space	NN
cord-285262-690kpupt	394	29	.	.	.
cord-285262-690kpupt	395	1	and	and	CC
cord-285262-690kpupt	395	2	is	be	VBZ
cord-285262-690kpupt	395	3	entirely	entirely	RB
cord-285262-690kpupt	395	4	independent	independent	JJ
cord-285262-690kpupt	395	5	from	from	IN
cord-285262-690kpupt	395	6	an	an	DT
cord-285262-690kpupt	395	7	indirect	indirect	JJ
cord-285262-690kpupt	395	8	effect	effect	NN
cord-285262-690kpupt	395	9	of	of	IN
cord-285262-690kpupt	395	10	IL	IL	NNP
cord-285262-690kpupt	395	11	production	production	NN
cord-285262-690kpupt	395	12	(	(	-LRB-
cord-285262-690kpupt	395	13	Wang	Wang	NNP
cord-285262-690kpupt	395	14	et	et	NNP
cord-285262-690kpupt	395	15	al	al	NNP
cord-285262-690kpupt	395	16	.	.	NNP
cord-285262-690kpupt	395	17	,	,	,
cord-285262-690kpupt	395	18	2019a	2019a	CD
cord-285262-690kpupt	395	19	)	)	-RRB-
cord-285262-690kpupt	395	20	.	.	.
cord-285262-690kpupt	396	1	Interestingly	interestingly	RB
cord-285262-690kpupt	396	2	,	,	,
cord-285262-690kpupt	396	3	GSDMD	GSDMD	NNP
cord-285262-690kpupt	396	4	is	be	VBZ
cord-285262-690kpupt	396	5	also	also	RB
cord-285262-690kpupt	396	6	capable	capable	JJ
cord-285262-690kpupt	396	7	to	to	TO
cord-285262-690kpupt	396	8	insert	insert	VB
cord-285262-690kpupt	396	9	into	into	IN
cord-285262-690kpupt	396	10	the	the	DT
cord-285262-690kpupt	396	11	bacterial	bacterial	JJ
cord-285262-690kpupt	396	12	membrane	membrane	NN
cord-285262-690kpupt	396	13	and	and	CC
cord-285262-690kpupt	396	14	to	to	TO
cord-285262-690kpupt	396	15	kill	kill	VB
cord-285262-690kpupt	396	16	extracellular	extracellular	JJ
cord-285262-690kpupt	396	17	bacteria	bacteria	NNS
cord-285262-690kpupt	396	18	(	(	-LRB-
cord-285262-690kpupt	396	19	Liu	Liu	NNP
cord-285262-690kpupt	396	20	et	et	NNP
cord-285262-690kpupt	396	21	al	al	NNP
cord-285262-690kpupt	396	22	.	.	NNP
cord-285262-690kpupt	396	23	,	,	,
cord-285262-690kpupt	396	24	2016	2016	CD
cord-285262-690kpupt	396	25	)	)	-RRB-
cord-285262-690kpupt	396	26	.	.	.
cord-285262-690kpupt	397	1	Thus	thus	RB
cord-285262-690kpupt	397	2	,	,	,
cord-285262-690kpupt	397	3	it	-PRON-	PRP
cord-285262-690kpupt	397	4	seems	seem	VBZ
cord-285262-690kpupt	397	5	that	that	IN
cord-285262-690kpupt	397	6	GSDMD	GSDMD	NNP
cord-285262-690kpupt	397	7	is	be	VBZ
cord-285262-690kpupt	397	8	represented	represent	VBN
cord-285262-690kpupt	397	9	at	at	IN
cord-285262-690kpupt	397	10	three	three	CD
cord-285262-690kpupt	397	11	different	different	JJ
cord-285262-690kpupt	397	12	layers	layer	NNS
cord-285262-690kpupt	397	13	of	of	IN
cord-285262-690kpupt	397	14	defense	defense	NN
cord-285262-690kpupt	397	15	depending	depend	VBG
cord-285262-690kpupt	397	16	on	on	IN
cord-285262-690kpupt	397	17	the	the	DT
cord-285262-690kpupt	397	18	localization	localization	NN
cord-285262-690kpupt	397	19	of	of	IN
cord-285262-690kpupt	397	20	the	the	DT
cord-285262-690kpupt	397	21	pathogen	pathogen	NN
cord-285262-690kpupt	397	22	.	.	.
cord-285262-690kpupt	398	1	Besides	besides	RB
cord-285262-690kpupt	398	2	,	,	,
cord-285262-690kpupt	398	3	gasdermin	gasdermin	NNP
cord-285262-690kpupt	398	4	E	E	NNP
cord-285262-690kpupt	398	5	,	,	,
cord-285262-690kpupt	398	6	another	another	DT
cord-285262-690kpupt	398	7	member	member	NN
cord-285262-690kpupt	398	8	of	of	IN
cord-285262-690kpupt	398	9	the	the	DT
cord-285262-690kpupt	398	10	gasdermin	gasdermin	NNP
cord-285262-690kpupt	398	11	family	family	NN
cord-285262-690kpupt	398	12	,	,	,
cord-285262-690kpupt	398	13	is	be	VBZ
cord-285262-690kpupt	398	14	also	also	RB
cord-285262-690kpupt	398	15	reported	report	VBN
cord-285262-690kpupt	398	16	to	to	TO
cord-285262-690kpupt	398	17	participate	participate	VB
cord-285262-690kpupt	398	18	in	in	IN
cord-285262-690kpupt	398	19	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	398	20	and	and	CC
cord-285262-690kpupt	398	21	in	in	IN
cord-285262-690kpupt	398	22	post	post	JJ
cord-285262-690kpupt	398	23	-	-	JJ
cord-285262-690kpupt	398	24	apoptotic	apoptotic	JJ
cord-285262-690kpupt	398	25	secondary	secondary	JJ
cord-285262-690kpupt	398	26	necrosis	necrosis	NN
cord-285262-690kpupt	398	27	(	(	-LRB-
cord-285262-690kpupt	398	28	Rogers	Rogers	NNP
cord-285262-690kpupt	398	29	et	et	NNP
cord-285262-690kpupt	398	30	al	al	NNP
cord-285262-690kpupt	398	31	.	.	NNP
cord-285262-690kpupt	398	32	,	,	,
cord-285262-690kpupt	398	33	2017	2017	CD
cord-285262-690kpupt	398	34	)	)	-RRB-
cord-285262-690kpupt	398	35	.	.	.
cord-285262-690kpupt	399	1	Whereas	whereas	IN
cord-285262-690kpupt	399	2	,	,	,
cord-285262-690kpupt	399	3	virus	virus	NN
cord-285262-690kpupt	399	4	triggered	trigger	VBD
cord-285262-690kpupt	399	5	inflammasome	inflammasome	NNP
cord-285262-690kpupt	399	6	activation	activation	NN
cord-285262-690kpupt	399	7	is	be	VBZ
cord-285262-690kpupt	399	8	a	a	DT
cord-285262-690kpupt	399	9	common	common	JJ
cord-285262-690kpupt	399	10	event	event	NN
cord-285262-690kpupt	399	11	,	,	,
cord-285262-690kpupt	399	12	inflammasome	inflammasome	NNP
cord-285262-690kpupt	399	13	induced	induce	VBN
cord-285262-690kpupt	399	14	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	399	15	can	can	MD
cord-285262-690kpupt	399	16	not	not	RB
cord-285262-690kpupt	399	17	be	be	VB
cord-285262-690kpupt	399	18	observed	observe	VBN
cord-285262-690kpupt	399	19	in	in	IN
cord-285262-690kpupt	399	20	all	all	DT
cord-285262-690kpupt	399	21	circumstances	circumstance	NNS
cord-285262-690kpupt	399	22	.	.	.
cord-285262-690kpupt	400	1	Nevertheless	nevertheless	RB
cord-285262-690kpupt	400	2	,	,	,
cord-285262-690kpupt	400	3	inflammasome	inflammasome	NNP
cord-285262-690kpupt	400	4	dependent	dependent	JJ
cord-285262-690kpupt	400	5	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	400	6	has	have	VBZ
cord-285262-690kpupt	400	7	been	be	VBN
cord-285262-690kpupt	400	8	reported	report	VBN
cord-285262-690kpupt	400	9	in	in	IN
cord-285262-690kpupt	400	10	response	response	NN
cord-285262-690kpupt	400	11	to	to	IN
cord-285262-690kpupt	400	12	infection	infection	NN
cord-285262-690kpupt	400	13	by	by	IN
cord-285262-690kpupt	400	14	several	several	JJ
cord-285262-690kpupt	400	15	viral	viral	JJ
cord-285262-690kpupt	400	16	pathogens	pathogen	NNS
cord-285262-690kpupt	400	17	,	,	,
cord-285262-690kpupt	400	18	including	include	VBG
cord-285262-690kpupt	400	19	HIV	HIV	NNP
cord-285262-690kpupt	400	20	,	,	,
cord-285262-690kpupt	400	21	DV	DV	NNP
cord-285262-690kpupt	400	22	(	(	-LRB-
cord-285262-690kpupt	400	23	Tan	Tan	NNP
cord-285262-690kpupt	400	24	and	and	CC
cord-285262-690kpupt	400	25	Chu	Chu	NNP
cord-285262-690kpupt	400	26	,	,	,
cord-285262-690kpupt	400	27	2013	2013	CD
cord-285262-690kpupt	400	28	)	)	-RRB-
cord-285262-690kpupt	400	29	,	,	,
cord-285262-690kpupt	400	30	IAV	IAV	NNP
cord-285262-690kpupt	400	31	,	,	,
cord-285262-690kpupt	400	32	Coxsacivirus	Coxsacivirus	NNP
cord-285262-690kpupt	400	33	(	(	-LRB-
cord-285262-690kpupt	400	34	CV	CV	NNP
cord-285262-690kpupt	400	35	)	)	-RRB-
cord-285262-690kpupt	400	36	,	,	,
cord-285262-690kpupt	400	37	Parvovirus	Parvovirus	NNP
cord-285262-690kpupt	400	38	(	(	-LRB-
cord-285262-690kpupt	400	39	Deng	Deng	NNP
cord-285262-690kpupt	400	40	et	et	FW
cord-285262-690kpupt	400	41	al	al	NNP
cord-285262-690kpupt	400	42	.	.	NNP
cord-285262-690kpupt	400	43	,	,	,
cord-285262-690kpupt	400	44	2017	2017	CD
cord-285262-690kpupt	400	45	)	)	-RRB-
cord-285262-690kpupt	400	46	,	,	,
cord-285262-690kpupt	400	47	hepatitis	hepatitis	NN
cord-285262-690kpupt	400	48	C	C	NNP
cord-285262-690kpupt	400	49	virus	virus	NN
cord-285262-690kpupt	400	50	(	(	-LRB-
cord-285262-690kpupt	400	51	Kofahi	Kofahi	NNP
cord-285262-690kpupt	400	52	et	et	NNP
cord-285262-690kpupt	400	53	al	al	NNP
cord-285262-690kpupt	400	54	.	.	NNP
cord-285262-690kpupt	400	55	,	,	,
cord-285262-690kpupt	400	56	2016	2016	CD
cord-285262-690kpupt	400	57	)	)	-RRB-
cord-285262-690kpupt	400	58	,	,	,
cord-285262-690kpupt	400	59	and	and	CC
cord-285262-690kpupt	400	60	Enterovirus	Enterovirus	NNP
cord-285262-690kpupt	400	61	71	71	CD
cord-285262-690kpupt	401	1	(	(	-LRB-
cord-285262-690kpupt	401	2	EV71	EV71	NNP
cord-285262-690kpupt	401	3	)	)	-RRB-
cord-285262-690kpupt	401	4	Zhu	Zhu	NNP
cord-285262-690kpupt	401	5	et	et	FW
cord-285262-690kpupt	401	6	al	al	NNP
cord-285262-690kpupt	401	7	.	.	NNP
cord-285262-690kpupt	401	8	,	,	,
cord-285262-690kpupt	401	9	2018	2018	CD
cord-285262-690kpupt	401	10	)	)	-RRB-
cord-285262-690kpupt	401	11	.	.	.
cord-285262-690kpupt	402	1	An	an	DT
cord-285262-690kpupt	402	2	in	in	IN
cord-285262-690kpupt	402	3	vivo	vivo	NN
cord-285262-690kpupt	402	4	study	study	NN
cord-285262-690kpupt	402	5	on	on	IN
cord-285262-690kpupt	402	6	attenuated	attenuated	JJ
cord-285262-690kpupt	402	7	Rabies	Rabies	NNP
cord-285262-690kpupt	402	8	strain	strain	NN
cord-285262-690kpupt	402	9	provides	provide	VBZ
cord-285262-690kpupt	402	10	evidence	evidence	NN
cord-285262-690kpupt	402	11	for	for	IN
cord-285262-690kpupt	402	12	the	the	DT
cord-285262-690kpupt	402	13	beneficial	beneficial	JJ
cord-285262-690kpupt	402	14	role	role	NN
cord-285262-690kpupt	402	15	of	of	IN
cord-285262-690kpupt	402	16	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	402	17	against	against	IN
cord-285262-690kpupt	402	18	viral	viral	JJ
cord-285262-690kpupt	402	19	infections	infection	NNS
cord-285262-690kpupt	402	20	.	.	.
cord-285262-690kpupt	403	1	The	the	DT
cord-285262-690kpupt	403	2	infection	infection	NN
cord-285262-690kpupt	403	3	with	with	IN
cord-285262-690kpupt	403	4	the	the	DT
cord-285262-690kpupt	403	5	attenuated	attenuated	JJ
cord-285262-690kpupt	403	6	Rabies	Rabies	NNP
cord-285262-690kpupt	403	7	virus	virus	NN
cord-285262-690kpupt	403	8	strain	strain	NN
cord-285262-690kpupt	403	9	,	,	,
cord-285262-690kpupt	403	10	which	which	WDT
cord-285262-690kpupt	403	11	normally	normally	RB
cord-285262-690kpupt	403	12	leads	lead	VBZ
cord-285262-690kpupt	403	13	to	to	IN
cord-285262-690kpupt	403	14	the	the	DT
cord-285262-690kpupt	403	15	onset	onset	NN
cord-285262-690kpupt	403	16	of	of	IN
cord-285262-690kpupt	403	17	mild	mild	JJ
cord-285262-690kpupt	403	18	symptoms	symptom	NNS
cord-285262-690kpupt	403	19	,	,	,
cord-285262-690kpupt	403	20	can	can	MD
cord-285262-690kpupt	403	21	be	be	VB
cord-285262-690kpupt	403	22	aggravated	aggravate	VBN
cord-285262-690kpupt	403	23	by	by	IN
cord-285262-690kpupt	403	24	caspase-1/-11	caspase-1/-11	PRP$
cord-285262-690kpupt	403	25	depletion	depletion	NN
cord-285262-690kpupt	403	26	,	,	,
cord-285262-690kpupt	403	27	but	but	CC
cord-285262-690kpupt	403	28	not	not	RB
cord-285262-690kpupt	403	29	by	by	IN
cord-285262-690kpupt	403	30	caspase-3/7	caspase-3/7	NNP
cord-285262-690kpupt	403	31	or	or	CC
cord-285262-690kpupt	403	32	by	by	IN
cord-285262-690kpupt	403	33	IL-1β	IL-1β	NNS
cord-285262-690kpupt	403	34	/	/	SYM
cord-285262-690kpupt	403	35	IL-18	IL-18	NNP
cord-285262-690kpupt	403	36	depletion	depletion	NN
cord-285262-690kpupt	403	37	(	(	-LRB-
cord-285262-690kpupt	403	38	Kip	Kip	NNP
cord-285262-690kpupt	403	39	et	et	NNP
cord-285262-690kpupt	403	40	al	al	NNP
cord-285262-690kpupt	403	41	.	.	NNP
cord-285262-690kpupt	403	42	,	,	,
cord-285262-690kpupt	403	43	2017	2017	CD
cord-285262-690kpupt	403	44	)	)	-RRB-
cord-285262-690kpupt	403	45	.	.	.
cord-285262-690kpupt	404	1	These	these	DT
cord-285262-690kpupt	404	2	observations	observation	NNS
cord-285262-690kpupt	404	3	suggest	suggest	VBP
cord-285262-690kpupt	404	4	that	that	IN
cord-285262-690kpupt	404	5	the	the	DT
cord-285262-690kpupt	404	6	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	404	7	can	can	MD
cord-285262-690kpupt	404	8	be	be	VB
cord-285262-690kpupt	404	9	necessary	necessary	JJ
cord-285262-690kpupt	404	10	to	to	TO
cord-285262-690kpupt	404	11	limit	limit	VB
cord-285262-690kpupt	404	12	the	the	DT
cord-285262-690kpupt	404	13	Rabies	Rabies	NNP
cord-285262-690kpupt	404	14	infection	infection	NN
cord-285262-690kpupt	404	15	.	.	.
cord-285262-690kpupt	405	1	Further	further	JJ
cord-285262-690kpupt	405	2	argument	argument	NN
cord-285262-690kpupt	405	3	for	for	IN
cord-285262-690kpupt	405	4	the	the	DT
cord-285262-690kpupt	405	5	anti	anti	JJ
cord-285262-690kpupt	405	6	-	-	JJ
cord-285262-690kpupt	405	7	viral	viral	JJ
cord-285262-690kpupt	405	8	nature	nature	NN
cord-285262-690kpupt	405	9	of	of	IN
cord-285262-690kpupt	405	10	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	405	11	is	be	VBZ
cord-285262-690kpupt	405	12	provided	provide	VBN
cord-285262-690kpupt	405	13	by	by	IN
cord-285262-690kpupt	405	14	the	the	DT
cord-285262-690kpupt	405	15	observation	observation	NN
cord-285262-690kpupt	405	16	that	that	IN
cord-285262-690kpupt	405	17	some	some	DT
cord-285262-690kpupt	405	18	viruses	virus	NNS
cord-285262-690kpupt	405	19	developed	develop	VBD
cord-285262-690kpupt	405	20	strategies	strategy	NNS
cord-285262-690kpupt	405	21	in	in	IN
cord-285262-690kpupt	405	22	order	order	NN
cord-285262-690kpupt	405	23	to	to	TO
cord-285262-690kpupt	405	24	inhibit	inhibit	VB
cord-285262-690kpupt	405	25	the	the	DT
cord-285262-690kpupt	405	26	effector	effector	NN
cord-285262-690kpupt	405	27	mechanisms	mechanism	NNS
cord-285262-690kpupt	405	28	of	of	IN
cord-285262-690kpupt	405	29	this	this	DT
cord-285262-690kpupt	405	30	lytic	lytic	JJ
cord-285262-690kpupt	405	31	cell	cell	NN
cord-285262-690kpupt	405	32	death	death	NN
cord-285262-690kpupt	405	33	modality	modality	NN
cord-285262-690kpupt	405	34	.	.	.
cord-285262-690kpupt	406	1	EV71	EV71	NNP
cord-285262-690kpupt	406	2	triggers	trigger	VBZ
cord-285262-690kpupt	406	3	GSDMD	GSDMD	NNP
cord-285262-690kpupt	406	4	by	by	IN
cord-285262-690kpupt	406	5	the	the	DT
cord-285262-690kpupt	406	6	viral	viral	JJ
cord-285262-690kpupt	406	7	protease	protease	NN
cord-285262-690kpupt	406	8	3C	3c	NN
cord-285262-690kpupt	406	9	,	,	,
cord-285262-690kpupt	406	10	and	and	CC
cord-285262-690kpupt	406	11	the	the	DT
cord-285262-690kpupt	406	12	cleaved	cleaved	JJ
cord-285262-690kpupt	406	13	fragments	fragment	NNS
cord-285262-690kpupt	406	14	fail	fail	VBP
cord-285262-690kpupt	406	15	to	to	TO
cord-285262-690kpupt	406	16	unleash	unleash	VB
cord-285262-690kpupt	406	17	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	406	18	in	in	IN
cord-285262-690kpupt	406	19	THP-1	THP-1	NNP
cord-285262-690kpupt	406	20	macrophages	macrophage	NNS
cord-285262-690kpupt	406	21	,	,	,
cord-285262-690kpupt	406	22	HEK293	HEK293	NNP
cord-285262-690kpupt	406	23	T	T	NNP
cord-285262-690kpupt	406	24	embryonal	embryonal	JJ
cord-285262-690kpupt	406	25	kidney	kidney	NN
cord-285262-690kpupt	406	26	and	and	CC
cord-285262-690kpupt	406	27	rhabdomyosarcoma	rhabdomyosarcoma	NNP
cord-285262-690kpupt	406	28	cell	cell	NN
cord-285262-690kpupt	406	29	lines	line	NNS
cord-285262-690kpupt	406	30	.	.	.
cord-285262-690kpupt	407	1	The	the	DT
cord-285262-690kpupt	407	2	nature	nature	NN
cord-285262-690kpupt	407	3	of	of	IN
cord-285262-690kpupt	407	4	the	the	DT
cord-285262-690kpupt	407	5	viral	viral	JJ
cord-285262-690kpupt	407	6	PAMPs	pamp	NNS
cord-285262-690kpupt	407	7	determines	determine	VBZ
cord-285262-690kpupt	407	8	which	which	WDT
cord-285262-690kpupt	407	9	inflammasome	inflammasome	NNP
cord-285262-690kpupt	407	10	mediated	mediate	VBD
cord-285262-690kpupt	407	11	pyroptotic	pyroptotic	JJ
cord-285262-690kpupt	407	12	pathway	pathway	NN
cord-285262-690kpupt	407	13	is	be	VBZ
cord-285262-690kpupt	407	14	activated	activate	VBN
cord-285262-690kpupt	407	15	in	in	IN
cord-285262-690kpupt	407	16	response	response	NN
cord-285262-690kpupt	407	17	to	to	IN
cord-285262-690kpupt	407	18	a	a	DT
cord-285262-690kpupt	407	19	specific	specific	JJ
cord-285262-690kpupt	407	20	stimulus	stimulus	NN
cord-285262-690kpupt	407	21	.	.	.
cord-285262-690kpupt	408	1	In	in	IN
cord-285262-690kpupt	408	2	accordance	accordance	NN
cord-285262-690kpupt	408	3	with	with	IN
cord-285262-690kpupt	408	4	this	this	DT
cord-285262-690kpupt	408	5	,	,	,
cord-285262-690kpupt	408	6	viral	viral	JJ
cord-285262-690kpupt	408	7	nucleotide	nucleotide	JJ
cord-285262-690kpupt	408	8	patterns	pattern	NNS
cord-285262-690kpupt	408	9	can	can	MD
cord-285262-690kpupt	408	10	lead	lead	VB
cord-285262-690kpupt	408	11	to	to	IN
cord-285262-690kpupt	408	12	the	the	DT
cord-285262-690kpupt	408	13	activation	activation	NN
cord-285262-690kpupt	408	14	of	of	IN
cord-285262-690kpupt	408	15	absent	absent	JJ
cord-285262-690kpupt	408	16	in	in	IN
cord-285262-690kpupt	408	17	melanoma-2	melanoma-2	NN
cord-285262-690kpupt	408	18	(	(	-LRB-
cord-285262-690kpupt	408	19	AIM2	AIM2	NNP
cord-285262-690kpupt	408	20	)	)	-RRB-
cord-285262-690kpupt	408	21	and	and	CC
cord-285262-690kpupt	408	22	interferon	interferon	NN
cord-285262-690kpupt	408	23	-	-	HYPH
cord-285262-690kpupt	408	24	γ	γ	NN
cord-285262-690kpupt	408	25	-	-	HYPH
cord-285262-690kpupt	408	26	inducible	inducible	JJ
cord-285262-690kpupt	408	27	protein	protein	NN
cord-285262-690kpupt	408	28	16	16	CD
cord-285262-690kpupt	408	29	(	(	-LRB-
cord-285262-690kpupt	408	30	IFI16	IFI16	NNP
cord-285262-690kpupt	408	31	)	)	-RRB-
cord-285262-690kpupt	408	32	inflammasome	inflammasome	NNP
cord-285262-690kpupt	408	33	activation	activation	NN
cord-285262-690kpupt	408	34	,	,	,
cord-285262-690kpupt	408	35	whereas	whereas	IN
cord-285262-690kpupt	408	36	various	various	JJ
cord-285262-690kpupt	408	37	virally	virally	RB
cord-285262-690kpupt	408	38	triggered	trigger	VBN
cord-285262-690kpupt	408	39	stress	stress	NN
cord-285262-690kpupt	408	40	signals	signal	NNS
cord-285262-690kpupt	408	41	can	can	MD
cord-285262-690kpupt	408	42	result	result	VB
cord-285262-690kpupt	408	43	in	in	IN
cord-285262-690kpupt	408	44	the	the	DT
cord-285262-690kpupt	408	45	assembly	assembly	NN
cord-285262-690kpupt	408	46	of	of	IN
cord-285262-690kpupt	408	47	the	the	DT
cord-285262-690kpupt	408	48	NOD	NOD	NNP
cord-285262-690kpupt	408	49	-	-	HYPH
cord-285262-690kpupt	408	50	like	like	JJ
cord-285262-690kpupt	408	51	receptor	receptor	NN
cord-285262-690kpupt	408	52	(	(	-LRB-
cord-285262-690kpupt	408	53	NLR	NLR	NNP
cord-285262-690kpupt	408	54	)	)	-RRB-
cord-285262-690kpupt	408	55	family	family	NN
cord-285262-690kpupt	408	56	pyrin	pyrin	NNP
cord-285262-690kpupt	408	57	domain	domain	NN
cord-285262-690kpupt	408	58	containing	contain	VBG
cord-285262-690kpupt	408	59	3	3	CD
cord-285262-690kpupt	409	1	(	(	-LRB-
cord-285262-690kpupt	409	2	NLRP3	NLRP3	NNP
cord-285262-690kpupt	409	3	)	)	-RRB-
cord-285262-690kpupt	409	4	inflammasome	inflammasome	NNP
cord-285262-690kpupt	409	5	(	(	-LRB-
cord-285262-690kpupt	409	6	Fig	Fig	NNP
cord-285262-690kpupt	409	7	.	.	.
cord-285262-690kpupt	409	8	3	3	CD
cord-285262-690kpupt	409	9	)	)	-RRB-
cord-285262-690kpupt	409	10	.	.	.
cord-285262-690kpupt	410	1	The	the	DT
cord-285262-690kpupt	410	2	role	role	NN
cord-285262-690kpupt	410	3	of	of	IN
cord-285262-690kpupt	410	4	NLRP3	nlrp3	XX
cord-285262-690kpupt	411	1	inflammasome	inflammasome	NNP
cord-285262-690kpupt	411	2	NLRP3	NLRP3	NNP
cord-285262-690kpupt	411	3	protein	protein	NN
cord-285262-690kpupt	411	4	is	be	VBZ
cord-285262-690kpupt	411	5	the	the	DT
cord-285262-690kpupt	411	6	major	major	JJ
cord-285262-690kpupt	411	7	component	component	NN
cord-285262-690kpupt	411	8	of	of	IN
cord-285262-690kpupt	411	9	the	the	DT
cord-285262-690kpupt	411	10	NLRP3	NLRP3	NNP
cord-285262-690kpupt	411	11	inflammasome	inflammasome	NNP
cord-285262-690kpupt	411	12	,	,	,
cord-285262-690kpupt	411	13	which	which	WDT
cord-285262-690kpupt	411	14	is	be	VBZ
cord-285262-690kpupt	411	15	the	the	DT
cord-285262-690kpupt	411	16	most	most	RBS
cord-285262-690kpupt	411	17	studied	study	VBN
cord-285262-690kpupt	411	18	inflammasome	inflammasome	NN
cord-285262-690kpupt	411	19	to	to	IN
cord-285262-690kpupt	411	20	date	date	NN
cord-285262-690kpupt	411	21	.	.	.
cord-285262-690kpupt	412	1	NLRP3	NLRP3	NNP
cord-285262-690kpupt	412	2	consist	consist	VBP
cord-285262-690kpupt	412	3	of	of	IN
cord-285262-690kpupt	412	4	a	a	DT
cord-285262-690kpupt	412	5	pyrin	pyrin	NN
cord-285262-690kpupt	412	6	domain	domain	NN
cord-285262-690kpupt	412	7	,	,	,
cord-285262-690kpupt	412	8	a	a	DT
cord-285262-690kpupt	412	9	nucleotide	nucleotide	JJ
cord-285262-690kpupt	412	10	binding	binding	NN
cord-285262-690kpupt	412	11	site	site	NN
cord-285262-690kpupt	412	12	,	,	,
cord-285262-690kpupt	412	13	and	and	CC
cord-285262-690kpupt	412	14	a	a	DT
cord-285262-690kpupt	412	15	leucine	leucine	NN
cord-285262-690kpupt	412	16	-	-	HYPH
cord-285262-690kpupt	412	17	rich	rich	JJ
cord-285262-690kpupt	412	18	repeat	repeat	NN
cord-285262-690kpupt	412	19	motif	motif	NN
cord-285262-690kpupt	412	20	.	.	.
cord-285262-690kpupt	413	1	Upon	upon	IN
cord-285262-690kpupt	413	2	activation	activation	NN
cord-285262-690kpupt	413	3	by	by	IN
cord-285262-690kpupt	413	4	PAMPs	pamp	NNS
cord-285262-690kpupt	413	5	,	,	,
cord-285262-690kpupt	413	6	NLRP3	nlrp3	NN
cord-285262-690kpupt	413	7	interacts	interact	VBZ
cord-285262-690kpupt	413	8	with	with	IN
cord-285262-690kpupt	413	9	the	the	DT
cord-285262-690kpupt	413	10	apoptosis	apoptosis	NN
cord-285262-690kpupt	413	11	-	-	HYPH
cord-285262-690kpupt	413	12	associated	associate	VBN
cord-285262-690kpupt	413	13	speck	speck	NN
cord-285262-690kpupt	413	14	-	-	HYPH
cord-285262-690kpupt	413	15	like	like	JJ
cord-285262-690kpupt	413	16	protein	protein	NN
cord-285262-690kpupt	413	17	(	(	-LRB-
cord-285262-690kpupt	413	18	ASC	ASC	NNP
cord-285262-690kpupt	413	19	)	)	-RRB-
cord-285262-690kpupt	413	20	via	via	IN
cord-285262-690kpupt	413	21	its	-PRON-	PRP$
cord-285262-690kpupt	413	22	pyrin	pyrin	NN
cord-285262-690kpupt	413	23	domain	domain	NN
cord-285262-690kpupt	413	24	(	(	-LRB-
cord-285262-690kpupt	413	25	Fig	Fig	NNP
cord-285262-690kpupt	413	26	.	.	.
cord-285262-690kpupt	413	27	3	3	CD
cord-285262-690kpupt	413	28	)	)	-RRB-
cord-285262-690kpupt	413	29	.	.	.
cord-285262-690kpupt	414	1	This	this	DT
cord-285262-690kpupt	414	2	in	in	IN
cord-285262-690kpupt	414	3	turn	turn	NN
cord-285262-690kpupt	414	4	induces	induce	VBZ
cord-285262-690kpupt	414	5	ASC	ASC	NNP
cord-285262-690kpupt	414	6	polymerization	polymerization	NN
cord-285262-690kpupt	414	7	and	and	CC
cord-285262-690kpupt	414	8	the	the	DT
cord-285262-690kpupt	414	9	assembly	assembly	NN
cord-285262-690kpupt	414	10	of	of	IN
cord-285262-690kpupt	414	11	the	the	DT
cord-285262-690kpupt	414	12	ASC	ASC	NNP
cord-285262-690kpupt	414	13	specks	speck	NNS
cord-285262-690kpupt	414	14	.	.	.
cord-285262-690kpupt	415	1	The	the	DT
cord-285262-690kpupt	415	2	adaptor	adaptor	NN
cord-285262-690kpupt	415	3	protein	protein	NN
cord-285262-690kpupt	415	4	ASC	ASC	NNP
cord-285262-690kpupt	415	5	possesses	possess	VBZ
cord-285262-690kpupt	415	6	a	a	DT
cord-285262-690kpupt	415	7	caspase	caspase	JJ
cord-285262-690kpupt	415	8	recruitment	recruitment	NN
cord-285262-690kpupt	415	9	CARD	card	NN
cord-285262-690kpupt	415	10	domain	domain	NN
cord-285262-690kpupt	415	11	and	and	CC
cord-285262-690kpupt	415	12	is	be	VBZ
cord-285262-690kpupt	415	13	therefore	therefore	RB
cord-285262-690kpupt	415	14	capable	capable	JJ
cord-285262-690kpupt	415	15	to	to	TO
cord-285262-690kpupt	415	16	recruit	recruit	VB
cord-285262-690kpupt	415	17	pro	pro	JJ
cord-285262-690kpupt	415	18	-	-	JJ
cord-285262-690kpupt	415	19	inflammatory	inflammatory	JJ
cord-285262-690kpupt	415	20	caspases	caspase	NNS
cord-285262-690kpupt	415	21	,	,	,
cord-285262-690kpupt	415	22	such	such	JJ
cord-285262-690kpupt	415	23	as	as	IN
cord-285262-690kpupt	415	24	caspase-1	caspase-1	NNP
cord-285262-690kpupt	415	25	(	(	-LRB-
cord-285262-690kpupt	415	26	Martinon	Martinon	NNP
cord-285262-690kpupt	415	27	,	,	,
cord-285262-690kpupt	415	28	2008	2008	CD
cord-285262-690kpupt	415	29	)	)	-RRB-
cord-285262-690kpupt	415	30	.	.	.
cord-285262-690kpupt	416	1	Consequently	consequently	RB
cord-285262-690kpupt	416	2	,	,	,
cord-285262-690kpupt	416	3	caspase-1	caspase-1	NNP
cord-285262-690kpupt	416	4	is	be	VBZ
cord-285262-690kpupt	416	5	dimerized	dimerize	VBN
cord-285262-690kpupt	416	6	and	and	CC
cord-285262-690kpupt	416	7	auto	auto	NN
cord-285262-690kpupt	416	8	-	-	HYPH
cord-285262-690kpupt	416	9	processed	process	VBN
cord-285262-690kpupt	416	10	based	base	VBN
cord-285262-690kpupt	416	11	on	on	IN
cord-285262-690kpupt	416	12	the	the	DT
cord-285262-690kpupt	416	13	principle	principle	NN
cord-285262-690kpupt	416	14	of	of	IN
cord-285262-690kpupt	416	15	the	the	DT
cord-285262-690kpupt	416	16	induced	induce	VBN
cord-285262-690kpupt	416	17	proximity	proximity	NN
cord-285262-690kpupt	416	18	.	.	.
cord-285262-690kpupt	417	1	Several	several	JJ
cord-285262-690kpupt	417	2	PAMP	PAMP	NNP
cord-285262-690kpupt	417	3	signals	signal	NNS
cord-285262-690kpupt	417	4	have	have	VBP
cord-285262-690kpupt	417	5	been	be	VBN
cord-285262-690kpupt	417	6	demonstrated	demonstrate	VBN
cord-285262-690kpupt	417	7	to	to	TO
cord-285262-690kpupt	417	8	culminate	culminate	VB
cord-285262-690kpupt	417	9	in	in	IN
cord-285262-690kpupt	417	10	NLRP3	NLRP3	NNP
cord-285262-690kpupt	417	11	activation	activation	NN
cord-285262-690kpupt	417	12	.	.	.
cord-285262-690kpupt	418	1	For	for	IN
cord-285262-690kpupt	418	2	instance	instance	NN
cord-285262-690kpupt	418	3	,	,	,
cord-285262-690kpupt	418	4	lytic	lytic	JJ
cord-285262-690kpupt	418	5	cell	cell	NN
cord-285262-690kpupt	418	6	death	death	NN
cord-285262-690kpupt	418	7	induced	induce	VBN
cord-285262-690kpupt	418	8	potassium	potassium	NN
cord-285262-690kpupt	418	9	efflux	efflux	NN
cord-285262-690kpupt	418	10	is	be	VBZ
cord-285262-690kpupt	418	11	proposed	propose	VBN
cord-285262-690kpupt	418	12	as	as	IN
cord-285262-690kpupt	418	13	the	the	DT
cord-285262-690kpupt	418	14	major	major	JJ
cord-285262-690kpupt	418	15	mechanism	mechanism	NN
cord-285262-690kpupt	418	16	of	of	IN
cord-285262-690kpupt	418	17	the	the	DT
cord-285262-690kpupt	418	18	NLRP3	NLRP3	NNP
cord-285262-690kpupt	418	19	inflammasome	inflammasome	NNP
cord-285262-690kpupt	418	20	activation	activation	NN
cord-285262-690kpupt	418	21	following	follow	VBG
cord-285262-690kpupt	418	22	Encephalomyocarditis	Encephalomyocarditis	NNP
cord-285262-690kpupt	418	23	virus	virus	NN
cord-285262-690kpupt	418	24	(	(	-LRB-
cord-285262-690kpupt	418	25	EMCV	EMCV	NNP
cord-285262-690kpupt	418	26	)	)	-RRB-
cord-285262-690kpupt	418	27	and	and	CC
cord-285262-690kpupt	418	28	VSV	VSV	NNP
cord-285262-690kpupt	418	29	infection	infection	NN
cord-285262-690kpupt	418	30	(	(	-LRB-
cord-285262-690kpupt	418	31	da	da	NNP
cord-285262-690kpupt	418	32	Costa	Costa	NNP
cord-285262-690kpupt	418	33	et	et	NNP
cord-285262-690kpupt	418	34	al	al	NNP
cord-285262-690kpupt	418	35	.	.	NNP
cord-285262-690kpupt	418	36	,	,	,
cord-285262-690kpupt	418	37	2019	2019	CD
cord-285262-690kpupt	418	38	)	)	-RRB-
cord-285262-690kpupt	418	39	.	.	.
cord-285262-690kpupt	419	1	In	in	IN
cord-285262-690kpupt	419	2	these	these	DT
cord-285262-690kpupt	419	3	infections	infection	NNS
cord-285262-690kpupt	419	4	,	,	,
cord-285262-690kpupt	419	5	the	the	DT
cord-285262-690kpupt	419	6	lytic	lytic	JJ
cord-285262-690kpupt	419	7	cell	cell	NN
cord-285262-690kpupt	419	8	death	death	NN
cord-285262-690kpupt	419	9	precedes	precede	VBZ
cord-285262-690kpupt	419	10	the	the	DT
cord-285262-690kpupt	419	11	inflammasome	inflammasome	NN
cord-285262-690kpupt	419	12	formation	formation	NN
cord-285262-690kpupt	419	13	,	,	,
cord-285262-690kpupt	419	14	whereas	whereas	IN
cord-285262-690kpupt	419	15	the	the	DT
cord-285262-690kpupt	419	16	infection	infection	NN
cord-285262-690kpupt	419	17	with	with	IN
cord-285262-690kpupt	419	18	IAV	IAV	NNP
cord-285262-690kpupt	419	19	results	result	NNS
cord-285262-690kpupt	419	20	in	in	IN
cord-285262-690kpupt	419	21	rapid	rapid	JJ
cord-285262-690kpupt	419	22	NLRP3	nlrp3	NN
cord-285262-690kpupt	419	23	dependent	dependent	JJ
cord-285262-690kpupt	419	24	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	419	25	in	in	IN
cord-285262-690kpupt	419	26	dendritic	dendritic	JJ
cord-285262-690kpupt	419	27	cells	cell	NNS
cord-285262-690kpupt	419	28	(	(	-LRB-
cord-285262-690kpupt	420	1	Fernandez	Fernandez	NNP
cord-285262-690kpupt	420	2	et	et	NNP
cord-285262-690kpupt	420	3	al	al	NNP
cord-285262-690kpupt	420	4	.	.	.
cord-285262-690kpupt	421	1	,	,	,
cord-285262-690kpupt	421	2	2016	2016	CD
cord-285262-690kpupt	421	3	;	;	:
cord-285262-690kpupt	421	4	Kuriakose	Kuriakose	NNP
cord-285262-690kpupt	421	5	et	et	NNP
cord-285262-690kpupt	421	6	al	al	NNP
cord-285262-690kpupt	421	7	.	.	NNP
cord-285262-690kpupt	421	8	,	,	,
cord-285262-690kpupt	421	9	2016	2016	CD
cord-285262-690kpupt	421	10	)	)	-RRB-
cord-285262-690kpupt	421	11	,	,	,
cord-285262-690kpupt	421	12	indicating	indicate	VBG
cord-285262-690kpupt	421	13	that	that	IN
cord-285262-690kpupt	421	14	other	other	JJ
cord-285262-690kpupt	421	15	mechanism	mechanism	NN
cord-285262-690kpupt	421	16	can	can	MD
cord-285262-690kpupt	421	17	also	also	RB
cord-285262-690kpupt	421	18	trigger	trigger	VB
cord-285262-690kpupt	421	19	NLRP3	NLRP3	NNP
cord-285262-690kpupt	421	20	assembly	assembly	NN
cord-285262-690kpupt	421	21	.	.	.
cord-285262-690kpupt	422	1	It	-PRON-	PRP
cord-285262-690kpupt	422	2	is	be	VBZ
cord-285262-690kpupt	422	3	of	of	IN
cord-285262-690kpupt	422	4	note	note	NN
cord-285262-690kpupt	422	5	,	,	,
cord-285262-690kpupt	422	6	that	that	IN
cord-285262-690kpupt	422	7	IAV	IAV	NNP
cord-285262-690kpupt	422	8	infection	infection	NN
cord-285262-690kpupt	422	9	results	result	VBZ
cord-285262-690kpupt	422	10	in	in	IN
cord-285262-690kpupt	422	11	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	422	12	with	with	IN
cord-285262-690kpupt	422	13	a	a	DT
cord-285262-690kpupt	422	14	delayed	delay	VBN
cord-285262-690kpupt	422	15	kinetic	kinetic	NN
cord-285262-690kpupt	422	16	in	in	IN
cord-285262-690kpupt	422	17	respiratory	respiratory	JJ
cord-285262-690kpupt	422	18	epithelial	epithelial	JJ
cord-285262-690kpupt	422	19	cells	cell	NNS
cord-285262-690kpupt	422	20	.	.	.
cord-285262-690kpupt	423	1	In	in	IN
cord-285262-690kpupt	423	2	the	the	DT
cord-285262-690kpupt	423	3	activation	activation	NN
cord-285262-690kpupt	423	4	of	of	IN
cord-285262-690kpupt	423	5	NLRP3	NLRP3	NNP
cord-285262-690kpupt	423	6	inflammasome	inflammasome	NNP
cord-285262-690kpupt	423	7	in	in	IN
cord-285262-690kpupt	423	8	DV	DV	NNP
cord-285262-690kpupt	423	9	infection	infection	NN
cord-285262-690kpupt	423	10	,	,	,
cord-285262-690kpupt	423	11	the	the	DT
cord-285262-690kpupt	423	12	cytoplasmic	cytoplasmic	JJ
cord-285262-690kpupt	423	13	membrane	membrane	NN
cord-285262-690kpupt	423	14	surface	surface	NN
cord-285262-690kpupt	423	15	C	c	NN
cord-285262-690kpupt	423	16	-	-	HYPH
cord-285262-690kpupt	423	17	type	type	NN
cord-285262-690kpupt	423	18	lectin	lectin	NN
cord-285262-690kpupt	423	19	5A	5a	NN
cord-285262-690kpupt	423	20	(	(	-LRB-
cord-285262-690kpupt	423	21	CLEC5A	CLEC5A	NNP
cord-285262-690kpupt	423	22	)	)	-RRB-
cord-285262-690kpupt	423	23	is	be	VBZ
cord-285262-690kpupt	423	24	found	find	VBN
cord-285262-690kpupt	423	25	to	to	TO
cord-285262-690kpupt	423	26	be	be	VB
cord-285262-690kpupt	423	27	critical	critical	JJ
cord-285262-690kpupt	423	28	,	,	,
cord-285262-690kpupt	423	29	which	which	WDT
cord-285262-690kpupt	423	30	interacts	interact	VBZ
cord-285262-690kpupt	423	31	directly	directly	RB
cord-285262-690kpupt	423	32	the	the	DT
cord-285262-690kpupt	423	33	DV	DV	NNP
cord-285262-690kpupt	423	34	virion	virion	NN
cord-285262-690kpupt	423	35	and	and	CC
cord-285262-690kpupt	423	36	serves	serve	VBZ
cord-285262-690kpupt	423	37	as	as	IN
cord-285262-690kpupt	423	38	a	a	DT
cord-285262-690kpupt	423	39	pathogen	pathogen	NN
cord-285262-690kpupt	423	40	sensing	sensing	NN
cord-285262-690kpupt	423	41	receptor	receptor	NN
cord-285262-690kpupt	423	42	in	in	IN
cord-285262-690kpupt	423	43	human	human	JJ
cord-285262-690kpupt	423	44	inflammatory	inflammatory	JJ
cord-285262-690kpupt	423	45	macrophages	macrophage	NNS
cord-285262-690kpupt	423	46	.	.	.
cord-285262-690kpupt	424	1	A	a	DT
cord-285262-690kpupt	424	2	highly	highly	RB
cord-285262-690kpupt	424	3	pathogenic	pathogenic	JJ
cord-285262-690kpupt	424	4	avian	avian	JJ
cord-285262-690kpupt	424	5	influenza	influenza	NN
cord-285262-690kpupt	424	6	A	a	NN
cord-285262-690kpupt	424	7	(	(	-LRB-
cord-285262-690kpupt	424	8	H5N1	H5N1	NNP
cord-285262-690kpupt	424	9	)	)	-RRB-
cord-285262-690kpupt	424	10	results	result	VBZ
cord-285262-690kpupt	424	11	in	in	IN
cord-285262-690kpupt	424	12	pneumonia	pneumonia	NN
cord-285262-690kpupt	424	13	and	and	CC
cord-285262-690kpupt	424	14	acute	acute	JJ
cord-285262-690kpupt	424	15	respiratory	respiratory	JJ
cord-285262-690kpupt	424	16	distress	distress	NN
cord-285262-690kpupt	424	17	syndrome	syndrome	NN
cord-285262-690kpupt	424	18	in	in	IN
cord-285262-690kpupt	424	19	humans	human	NNS
cord-285262-690kpupt	424	20	.	.	.
cord-285262-690kpupt	425	1	The	the	DT
cord-285262-690kpupt	425	2	depletion	depletion	NN
cord-285262-690kpupt	425	3	of	of	IN
cord-285262-690kpupt	425	4	galectin	galectin	NNP
cord-285262-690kpupt	425	5	-	-	HYPH
cord-285262-690kpupt	425	6	B	B	NNP
cord-285262-690kpupt	425	7	,	,	,
cord-285262-690kpupt	425	8	a	a	DT
cord-285262-690kpupt	425	9	b	b	NN
cord-285262-690kpupt	425	10	-	-	HYPH
cord-285262-690kpupt	425	11	galactosidase	galactosidase	NN
cord-285262-690kpupt	425	12	binding	bind	VBG
cord-285262-690kpupt	425	13	protein	protein	NN
cord-285262-690kpupt	425	14	leads	lead	VBZ
cord-285262-690kpupt	425	15	to	to	IN
cord-285262-690kpupt	425	16	a	a	DT
cord-285262-690kpupt	425	17	striking	striking	JJ
cord-285262-690kpupt	425	18	reduction	reduction	NN
cord-285262-690kpupt	425	19	of	of	IN
cord-285262-690kpupt	425	20	inflammation	inflammation	NN
cord-285262-690kpupt	425	21	in	in	IN
cord-285262-690kpupt	425	22	lungs	lung	NNS
cord-285262-690kpupt	425	23	of	of	IN
cord-285262-690kpupt	425	24	the	the	DT
cord-285262-690kpupt	425	25	infected	infected	JJ
cord-285262-690kpupt	425	26	mice	mouse	NNS
cord-285262-690kpupt	425	27	compared	compare	VBN
cord-285262-690kpupt	425	28	to	to	IN
cord-285262-690kpupt	425	29	that	that	DT
cord-285262-690kpupt	425	30	of	of	IN
cord-285262-690kpupt	425	31	the	the	DT
cord-285262-690kpupt	425	32	wild	wild	JJ
cord-285262-690kpupt	425	33	type	type	NN
cord-285262-690kpupt	425	34	mice	mouse	NNS
cord-285262-690kpupt	425	35	.	.	.
cord-285262-690kpupt	426	1	Consequently	consequently	RB
cord-285262-690kpupt	426	2	,	,	,
cord-285262-690kpupt	426	3	co	co	JJ
cord-285262-690kpupt	426	4	-	-	JJ
cord-285262-690kpupt	426	5	immunoprecipitation	immunoprecipitation	JJ
cord-285262-690kpupt	426	6	experiments	experiment	NNS
cord-285262-690kpupt	426	7	demonstrate	demonstrate	VBP
cord-285262-690kpupt	426	8	the	the	DT
cord-285262-690kpupt	426	9	interaction	interaction	NN
cord-285262-690kpupt	426	10	of	of	IN
cord-285262-690kpupt	426	11	galectin	galectin	NNP
cord-285262-690kpupt	426	12	-	-	HYPH
cord-285262-690kpupt	426	13	B	B	NNP
cord-285262-690kpupt	426	14	,	,	,
cord-285262-690kpupt	426	15	NLRP3	nlrp3	NN
cord-285262-690kpupt	426	16	and	and	CC
cord-285262-690kpupt	426	17	ASC	ASC	NNP
cord-285262-690kpupt	426	18	in	in	IN
cord-285262-690kpupt	426	19	bone	bone	NN
cord-285262-690kpupt	426	20	marrow	marrow	NN
cord-285262-690kpupt	426	21	-	-	HYPH
cord-285262-690kpupt	426	22	derived	derive	VBN
cord-285262-690kpupt	426	23	macrophages	macrophage	NNS
cord-285262-690kpupt	426	24	upon	upon	IN
cord-285262-690kpupt	426	25	infection	infection	NN
cord-285262-690kpupt	426	26	.	.	.
cord-285262-690kpupt	427	1	The	the	DT
cord-285262-690kpupt	427	2	gp120	gp120	NN
cord-285262-690kpupt	427	3	envelop	envelop	VBP
cord-285262-690kpupt	427	4	protein	protein	NN
cord-285262-690kpupt	427	5	of	of	IN
cord-285262-690kpupt	427	6	the	the	DT
cord-285262-690kpupt	427	7	HIV	HIV	NNP
cord-285262-690kpupt	427	8	is	be	VBZ
cord-285262-690kpupt	427	9	the	the	DT
cord-285262-690kpupt	427	10	major	major	JJ
cord-285262-690kpupt	427	11	contributing	contribute	VBG
cord-285262-690kpupt	427	12	factor	factor	NN
cord-285262-690kpupt	427	13	of	of	IN
cord-285262-690kpupt	427	14	the	the	DT
cord-285262-690kpupt	427	15	HIV	HIV	NNP
cord-285262-690kpupt	427	16	-	-	HYPH
cord-285262-690kpupt	427	17	associated	associate	VBN
cord-285262-690kpupt	427	18	neurocognitive	neurocognitive	JJ
cord-285262-690kpupt	427	19	disorder	disorder	NN
cord-285262-690kpupt	427	20	accompanied	accompany	VBN
cord-285262-690kpupt	427	21	by	by	IN
cord-285262-690kpupt	427	22	neuroinflammation	neuroinflammation	NN
cord-285262-690kpupt	427	23	.	.	.
cord-285262-690kpupt	428	1	The	the	DT
cord-285262-690kpupt	428	2	gp120	gp120	CD
cord-285262-690kpupt	428	3	triggered	trigger	VBN
cord-285262-690kpupt	428	4	neuropathy	neuropathy	NN
cord-285262-690kpupt	428	5	is	be	VBZ
cord-285262-690kpupt	428	6	NLRP3	nlrp3	RB
cord-285262-690kpupt	428	7	dependent	dependent	JJ
cord-285262-690kpupt	428	8	and	and	CC
cord-285262-690kpupt	428	9	the	the	DT
cord-285262-690kpupt	428	10	administration	administration	NN
cord-285262-690kpupt	428	11	of	of	IN
cord-285262-690kpupt	428	12	a	a	DT
cord-285262-690kpupt	428	13	selective	selective	JJ
cord-285262-690kpupt	428	14	NLRP3	nlrp3	NN
cord-285262-690kpupt	428	15	inhibitor	inhibitor	NN
cord-285262-690kpupt	428	16	can	can	MD
cord-285262-690kpupt	428	17	alleviate	alleviate	VB
cord-285262-690kpupt	428	18	the	the	DT
cord-285262-690kpupt	428	19	neuronal	neuronal	JJ
cord-285262-690kpupt	428	20	death	death	NN
cord-285262-690kpupt	428	21	and	and	CC
cord-285262-690kpupt	428	22	the	the	DT
cord-285262-690kpupt	428	23	impaired	impair	VBN
cord-285262-690kpupt	428	24	cognitive	cognitive	JJ
cord-285262-690kpupt	428	25	functions	function	NNS
cord-285262-690kpupt	428	26	in	in	IN
cord-285262-690kpupt	428	27	gp120	gp120	DT
cord-285262-690kpupt	428	28	transgenic	transgenic	JJ
cord-285262-690kpupt	428	29	mice	mouse	NNS
cord-285262-690kpupt	428	30	.	.	.
cord-285262-690kpupt	429	1	In	in	IN
cord-285262-690kpupt	429	2	a	a	DT
cord-285262-690kpupt	429	3	recent	recent	JJ
cord-285262-690kpupt	429	4	study	study	NN
cord-285262-690kpupt	429	5	,	,	,
cord-285262-690kpupt	429	6	the	the	DT
cord-285262-690kpupt	429	7	role	role	NN
cord-285262-690kpupt	429	8	of	of	IN
cord-285262-690kpupt	429	9	the	the	DT
cord-285262-690kpupt	429	10	Purinergic	Purinergic	NNP
cord-285262-690kpupt	429	11	2X4	2x4	CD
cord-285262-690kpupt	429	12	(	(	-LRB-
cord-285262-690kpupt	429	13	P2X4	P2X4	NNP
cord-285262-690kpupt	429	14	)	)	-RRB-
cord-285262-690kpupt	429	15	,	,	,
cord-285262-690kpupt	429	16	a	a	DT
cord-285262-690kpupt	429	17	cationic	cationic	JJ
cord-285262-690kpupt	429	18	ion	ion	NN
cord-285262-690kpupt	429	19	channel	channel	NN
cord-285262-690kpupt	429	20	involved	involve	VBN
cord-285262-690kpupt	429	21	in	in	IN
cord-285262-690kpupt	429	22	neuropathic	neuropathic	JJ
cord-285262-690kpupt	429	23	pain	pain	NN
cord-285262-690kpupt	429	24	,	,	,
cord-285262-690kpupt	429	25	is	be	VBZ
cord-285262-690kpupt	429	26	shown	show	VBN
cord-285262-690kpupt	429	27	to	to	TO
cord-285262-690kpupt	429	28	mediate	mediate	VB
cord-285262-690kpupt	429	29	the	the	DT
cord-285262-690kpupt	429	30	gp120	gp120	NNP
cord-285262-690kpupt	429	31	dependent	dependent	JJ
cord-285262-690kpupt	429	32	inflammasome	inflammasome	NN
cord-285262-690kpupt	429	33	activation	activation	NN
cord-285262-690kpupt	429	34	and	and	CC
cord-285262-690kpupt	429	35	the	the	DT
cord-285262-690kpupt	429	36	caspase-1	caspase-1	NNP
cord-285262-690kpupt	429	37	cleavage	cleavage	NN
cord-285262-690kpupt	429	38	in	in	IN
cord-285262-690kpupt	429	39	glial	glial	JJ
cord-285262-690kpupt	429	40	cells	cell	NNS
cord-285262-690kpupt	429	41	.	.	.
cord-285262-690kpupt	430	1	Most	Most	JJS
cord-285262-690kpupt	430	2	of	of	IN
cord-285262-690kpupt	430	3	these	these	DT
cord-285262-690kpupt	430	4	studies	study	NNS
cord-285262-690kpupt	430	5	indicate	indicate	VBP
cord-285262-690kpupt	430	6	the	the	DT
cord-285262-690kpupt	430	7	role	role	NN
cord-285262-690kpupt	430	8	of	of	IN
cord-285262-690kpupt	430	9	osmotic	osmotic	JJ
cord-285262-690kpupt	430	10	imbalances	imbalance	NNS
cord-285262-690kpupt	430	11	,	,	,
cord-285262-690kpupt	430	12	such	such	JJ
cord-285262-690kpupt	430	13	as	as	IN
cord-285262-690kpupt	430	14	potassium	potassium	NN
cord-285262-690kpupt	430	15	efflux	efflux	NN
cord-285262-690kpupt	430	16	as	as	IN
cord-285262-690kpupt	430	17	one	one	CD
cord-285262-690kpupt	430	18	of	of	IN
cord-285262-690kpupt	430	19	the	the	DT
cord-285262-690kpupt	430	20	major	major	JJ
cord-285262-690kpupt	430	21	causative	causative	NN
cord-285262-690kpupt	430	22	of	of	IN
cord-285262-690kpupt	430	23	NLRP3	NLRP3	NNP
cord-285262-690kpupt	430	24	inflammasome	inflammasome	JJ
cord-285262-690kpupt	430	25	stimulation	stimulation	NN
cord-285262-690kpupt	430	26	,	,	,
cord-285262-690kpupt	430	27	however	however	RB
cord-285262-690kpupt	430	28	,	,	,
cord-285262-690kpupt	430	29	how	how	WRB
cord-285262-690kpupt	430	30	the	the	DT
cord-285262-690kpupt	430	31	low	low	JJ
cord-285262-690kpupt	430	32	potassium	potassium	NN
cord-285262-690kpupt	430	33	concentration	concentration	NN
cord-285262-690kpupt	430	34	renders	render	VBZ
cord-285262-690kpupt	430	35	changes	change	NNS
cord-285262-690kpupt	430	36	in	in	IN
cord-285262-690kpupt	430	37	the	the	DT
cord-285262-690kpupt	430	38	NLRP3	nlrp3	NN
cord-285262-690kpupt	430	39	structure	structure	NN
cord-285262-690kpupt	430	40	and	and	CC
cord-285262-690kpupt	430	41	whether	whether	IN
cord-285262-690kpupt	430	42	this	this	DT
cord-285262-690kpupt	430	43	is	be	VBZ
cord-285262-690kpupt	430	44	a	a	DT
cord-285262-690kpupt	430	45	direct	direct	JJ
cord-285262-690kpupt	430	46	or	or	CC
cord-285262-690kpupt	430	47	an	an	DT
cord-285262-690kpupt	430	48	indirect	indirect	JJ
cord-285262-690kpupt	430	49	effect	effect	NN
cord-285262-690kpupt	430	50	still	still	RB
cord-285262-690kpupt	430	51	needs	need	VBZ
cord-285262-690kpupt	430	52	to	to	TO
cord-285262-690kpupt	430	53	be	be	VB
cord-285262-690kpupt	430	54	clarified	clarify	VBN
cord-285262-690kpupt	430	55	.	.	.
cord-285262-690kpupt	431	1	The	the	DT
cord-285262-690kpupt	431	2	role	role	NN
cord-285262-690kpupt	431	3	of	of	IN
cord-285262-690kpupt	431	4	IFI16	ifi16	NN
cord-285262-690kpupt	431	5	in	in	IN
cord-285262-690kpupt	431	6	the	the	DT
cord-285262-690kpupt	431	7	HIV	HIV	NNP
cord-285262-690kpupt	431	8	induced	induce	VBD
cord-285262-690kpupt	431	9	T	T	NNP
cord-285262-690kpupt	431	10	lymphocyte	lymphocyte	NN
cord-285262-690kpupt	431	11	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	431	12	HIV	HIV	NNP
cord-285262-690kpupt	431	13	triggers	trigger	VBZ
cord-285262-690kpupt	431	14	bystander	bystander	NN
cord-285262-690kpupt	431	15	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	431	16	in	in	IN
cord-285262-690kpupt	431	17	non	non	JJ
cord-285262-690kpupt	431	18	-	-	JJ
cord-285262-690kpupt	431	19	infected	infected	JJ
cord-285262-690kpupt	431	20	T	t	NN
cord-285262-690kpupt	431	21	lymphocytes	lymphocyte	NNS
cord-285262-690kpupt	431	22	.	.	.
cord-285262-690kpupt	432	1	The	the	DT
cord-285262-690kpupt	432	2	bystander	bystander	NN
cord-285262-690kpupt	432	3	CD4	CD4	NNP
cord-285262-690kpupt	432	4	T	T	NNP
cord-285262-690kpupt	432	5	cells	cell	NNS
cord-285262-690kpupt	432	6	,	,	,
cord-285262-690kpupt	432	7	that	that	WDT
cord-285262-690kpupt	432	8	are	be	VBP
cord-285262-690kpupt	432	9	not	not	RB
cord-285262-690kpupt	432	10	permissive	permissive	JJ
cord-285262-690kpupt	432	11	to	to	IN
cord-285262-690kpupt	432	12	HIV	HIV	NNP
cord-285262-690kpupt	432	13	infection	infection	NN
cord-285262-690kpupt	432	14	,	,	,
cord-285262-690kpupt	432	15	play	play	VB
cord-285262-690kpupt	432	16	a	a	DT
cord-285262-690kpupt	432	17	crucial	crucial	JJ
cord-285262-690kpupt	432	18	role	role	NN
cord-285262-690kpupt	432	19	in	in	IN
cord-285262-690kpupt	432	20	the	the	DT
cord-285262-690kpupt	432	21	acquired	acquire	VBN
cord-285262-690kpupt	432	22	immunodeficiency	immunodeficiency	NN
cord-285262-690kpupt	432	23	syndrome	syndrome	NN
cord-285262-690kpupt	432	24	(	(	-LRB-
cord-285262-690kpupt	432	25	AIDS	AIDS	NNP
cord-285262-690kpupt	432	26	)	)	-RRB-
cord-285262-690kpupt	432	27	.	.	.
cord-285262-690kpupt	433	1	These	these	DT
cord-285262-690kpupt	433	2	cells	cell	NNS
cord-285262-690kpupt	433	3	go	go	VBP
cord-285262-690kpupt	433	4	through	through	IN
cord-285262-690kpupt	433	5	an	an	DT
cord-285262-690kpupt	433	6	incomplete	incomplete	JJ
cord-285262-690kpupt	433	7	virus	virus	NN
cord-285262-690kpupt	433	8	replication	replication	NN
cord-285262-690kpupt	433	9	cycle	cycle	NN
cord-285262-690kpupt	433	10	,	,	,
cord-285262-690kpupt	433	11	resulting	result	VBG
cord-285262-690kpupt	433	12	in	in	IN
cord-285262-690kpupt	433	13	aberrant	aberrant	JJ
cord-285262-690kpupt	433	14	transcripts	transcript	NNS
cord-285262-690kpupt	433	15	of	of	IN
cord-285262-690kpupt	433	16	the	the	DT
cord-285262-690kpupt	433	17	viral	viral	JJ
cord-285262-690kpupt	433	18	genome	genome	NN
cord-285262-690kpupt	433	19	.	.	.
cord-285262-690kpupt	434	1	These	these	DT
cord-285262-690kpupt	434	2	transcripts	transcript	NNS
cord-285262-690kpupt	434	3	have	have	VBP
cord-285262-690kpupt	434	4	been	be	VBN
cord-285262-690kpupt	434	5	demonstrated	demonstrate	VBN
cord-285262-690kpupt	434	6	to	to	TO
cord-285262-690kpupt	434	7	stimulate	stimulate	VB
cord-285262-690kpupt	434	8	the	the	DT
cord-285262-690kpupt	434	9	DNA	dna	NN
cord-285262-690kpupt	434	10	sensor	sensor	NN
cord-285262-690kpupt	434	11	interferon	interferon	NN
cord-285262-690kpupt	434	12	-	-	HYPH
cord-285262-690kpupt	434	13	γ	γ	NN
cord-285262-690kpupt	434	14	-	-	HYPH
cord-285262-690kpupt	434	15	inducible	inducible	JJ
cord-285262-690kpupt	434	16	protein	protein	NN
cord-285262-690kpupt	434	17	16	16	CD
cord-285262-690kpupt	434	18	(	(	-LRB-
cord-285262-690kpupt	434	19	IFI16	IFI16	NNP
cord-285262-690kpupt	434	20	)	)	-RRB-
cord-285262-690kpupt	434	21	,	,	,
cord-285262-690kpupt	434	22	leading	lead	VBG
cord-285262-690kpupt	434	23	to	to	IN
cord-285262-690kpupt	434	24	caspase-1	caspase-1	NNP
cord-285262-690kpupt	434	25	activation	activation	NN
cord-285262-690kpupt	434	26	mediated	mediate	VBN
cord-285262-690kpupt	434	27	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	434	28	(	(	-LRB-
cord-285262-690kpupt	434	29	Fig	Fig	NNP
cord-285262-690kpupt	434	30	.	.	.
cord-285262-690kpupt	434	31	3	3	CD
cord-285262-690kpupt	434	32	)	)	-RRB-
cord-285262-690kpupt	434	33	.	.	.
cord-285262-690kpupt	435	1	The	the	DT
cord-285262-690kpupt	435	2	immune	immune	JJ
cord-285262-690kpupt	435	3	stimulatory	stimulatory	JJ
cord-285262-690kpupt	435	4	dying	dying	NN
cord-285262-690kpupt	435	5	of	of	IN
cord-285262-690kpupt	435	6	the	the	DT
cord-285262-690kpupt	435	7	T	t	NN
cord-285262-690kpupt	435	8	lymphocytes	lymphocyte	NNS
cord-285262-690kpupt	435	9	initiates	initiate	VBZ
cord-285262-690kpupt	435	10	a	a	DT
cord-285262-690kpupt	435	11	pathogenic	pathogenic	JJ
cord-285262-690kpupt	435	12	positive	positive	JJ
cord-285262-690kpupt	435	13	feedback	feedback	NN
cord-285262-690kpupt	435	14	loop	loop	NN
cord-285262-690kpupt	435	15	by	by	IN
cord-285262-690kpupt	435	16	recruiting	recruit	VBG
cord-285262-690kpupt	435	17	more	more	JJR
cord-285262-690kpupt	435	18	immune	immune	JJ
cord-285262-690kpupt	435	19	cells	cell	NNS
cord-285262-690kpupt	435	20	to	to	IN
cord-285262-690kpupt	435	21	the	the	DT
cord-285262-690kpupt	435	22	site	site	NN
cord-285262-690kpupt	435	23	of	of	IN
cord-285262-690kpupt	435	24	infections	infection	NNS
cord-285262-690kpupt	435	25	,	,	,
cord-285262-690kpupt	435	26	which	which	WDT
cord-285262-690kpupt	435	27	leads	lead	VBZ
cord-285262-690kpupt	435	28	to	to	IN
cord-285262-690kpupt	435	29	even	even	RB
cord-285262-690kpupt	435	30	more	more	RBR
cord-285262-690kpupt	435	31	accelerated	accelerated	JJ
cord-285262-690kpupt	435	32	propagation	propagation	NN
cord-285262-690kpupt	435	33	of	of	IN
cord-285262-690kpupt	435	34	the	the	DT
cord-285262-690kpupt	435	35	virus	virus	NN
cord-285262-690kpupt	435	36	.	.	.
cord-285262-690kpupt	436	1	Cell	cell	NN
cord-285262-690kpupt	436	2	free	free	JJ
cord-285262-690kpupt	436	3	virions	virion	NNS
cord-285262-690kpupt	436	4	are	be	VBP
cord-285262-690kpupt	436	5	unable	unable	JJ
cord-285262-690kpupt	436	6	to	to	TO
cord-285262-690kpupt	436	7	trigger	trigger	VB
cord-285262-690kpupt	436	8	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	436	9	.	.	.
cord-285262-690kpupt	437	1	Thus	thus	RB
cord-285262-690kpupt	437	2	,	,	,
cord-285262-690kpupt	437	3	a	a	DT
cord-285262-690kpupt	437	4	cell	cell	NN
cord-285262-690kpupt	437	5	to	to	IN
cord-285262-690kpupt	437	6	cell	cell	NN
cord-285262-690kpupt	437	7	transmission	transmission	NN
cord-285262-690kpupt	437	8	of	of	IN
cord-285262-690kpupt	437	9	the	the	DT
cord-285262-690kpupt	437	10	virions	virion	NNS
cord-285262-690kpupt	437	11	is	be	VBZ
cord-285262-690kpupt	437	12	required	require	VBN
cord-285262-690kpupt	437	13	for	for	IN
cord-285262-690kpupt	437	14	the	the	DT
cord-285262-690kpupt	437	15	induction	induction	NN
cord-285262-690kpupt	437	16	of	of	IN
cord-285262-690kpupt	437	17	this	this	DT
cord-285262-690kpupt	437	18	lytic	lytic	JJ
cord-285262-690kpupt	437	19	inflammatory	inflammatory	JJ
cord-285262-690kpupt	437	20	cell	cell	NN
cord-285262-690kpupt	437	21	death	death	NN
cord-285262-690kpupt	437	22	(	(	-LRB-
cord-285262-690kpupt	437	23	Galloway	Galloway	NNP
cord-285262-690kpupt	437	24	et	et	NNP
cord-285262-690kpupt	437	25	al	al	NNP
cord-285262-690kpupt	437	26	.	.	NNP
cord-285262-690kpupt	437	27	,	,	,
cord-285262-690kpupt	437	28	2015	2015	CD
cord-285262-690kpupt	437	29	)	)	-RRB-
cord-285262-690kpupt	437	30	.	.	.
cord-285262-690kpupt	438	1	A	a	DT
cord-285262-690kpupt	438	2	clinical	clinical	JJ
cord-285262-690kpupt	438	3	antiretroviral	antiretroviral	JJ
cord-285262-690kpupt	438	4	therapy	therapy	NN
cord-285262-690kpupt	438	5	study	study	NN
cord-285262-690kpupt	438	6	in	in	IN
cord-285262-690kpupt	438	7	humans	human	NNS
cord-285262-690kpupt	438	8	demonstrates	demonstrate	VBZ
cord-285262-690kpupt	438	9	that	that	IN
cord-285262-690kpupt	438	10	the	the	DT
cord-285262-690kpupt	438	11	non	non	NN
cord-285262-690kpupt	438	12	-	-	JJ
cord-285262-690kpupt	438	13	responding	respond	VBG
cord-285262-690kpupt	438	14	individuals	individual	NNS
cord-285262-690kpupt	438	15	have	have	VBP
cord-285262-690kpupt	438	16	increased	increase	VBN
cord-285262-690kpupt	438	17	level	level	NN
cord-285262-690kpupt	438	18	of	of	IN
cord-285262-690kpupt	438	19	NLRP3	nlrp3	NN
cord-285262-690kpupt	438	20	and	and	CC
cord-285262-690kpupt	438	21	caspase-1	caspase-1	NNP
cord-285262-690kpupt	438	22	.	.	.
cord-285262-690kpupt	439	1	In	in	IN
cord-285262-690kpupt	439	2	addition	addition	NN
cord-285262-690kpupt	439	3	,	,	,
cord-285262-690kpupt	439	4	the	the	DT
cord-285262-690kpupt	439	5	non	non	NN
cord-285262-690kpupt	439	6	-	-	JJ
cord-285262-690kpupt	439	7	responding	respond	VBG
cord-285262-690kpupt	439	8	group	group	NN
cord-285262-690kpupt	439	9	exhibits	exhibit	VBZ
cord-285262-690kpupt	439	10	significantly	significantly	RB
cord-285262-690kpupt	439	11	lower	low	JJR
cord-285262-690kpupt	439	12	levels	level	NNS
cord-285262-690kpupt	439	13	of	of	IN
cord-285262-690kpupt	439	14	CD4	CD4	NNP
cord-285262-690kpupt	439	15	T	T	NNP
cord-285262-690kpupt	439	16	lymphocytes	lymphocyte	NNS
cord-285262-690kpupt	439	17	in	in	IN
cord-285262-690kpupt	439	18	comparison	comparison	NN
cord-285262-690kpupt	439	19	to	to	IN
cord-285262-690kpupt	439	20	that	that	DT
cord-285262-690kpupt	439	21	of	of	IN
cord-285262-690kpupt	439	22	the	the	DT
cord-285262-690kpupt	439	23	responder	responder	NN
cord-285262-690kpupt	439	24	patients	patient	NNS
cord-285262-690kpupt	439	25	.	.	.
cord-285262-690kpupt	440	1	Though	though	RB
cord-285262-690kpupt	440	2	,	,	,
cord-285262-690kpupt	440	3	this	this	DT
cord-285262-690kpupt	440	4	patient	patient	NN
cord-285262-690kpupt	440	5	data	data	NN
cord-285262-690kpupt	440	6	supports	support	VBZ
cord-285262-690kpupt	440	7	the	the	DT
cord-285262-690kpupt	440	8	previous	previous	JJ
cord-285262-690kpupt	440	9	in	in	IN
cord-285262-690kpupt	440	10	vitro	vitro	FW
cord-285262-690kpupt	440	11	and	and	CC
cord-285262-690kpupt	440	12	mouse	mouse	NN
cord-285262-690kpupt	440	13	experiments	experiment	NNS
cord-285262-690kpupt	440	14	,	,	,
cord-285262-690kpupt	440	15	which	which	WDT
cord-285262-690kpupt	440	16	suggest	suggest	VBP
cord-285262-690kpupt	440	17	the	the	DT
cord-285262-690kpupt	440	18	relevance	relevance	NN
cord-285262-690kpupt	440	19	of	of	IN
cord-285262-690kpupt	440	20	CD4	CD4	NNP
cord-285262-690kpupt	440	21	lymphocyte	lymphocyte	NN
cord-285262-690kpupt	440	22	loss	loss	NN
cord-285262-690kpupt	440	23	in	in	IN
cord-285262-690kpupt	440	24	the	the	DT
cord-285262-690kpupt	440	25	pathogenesis	pathogenesis	NN
cord-285262-690kpupt	440	26	of	of	IN
cord-285262-690kpupt	440	27	HIV	HIV	NNP
cord-285262-690kpupt	440	28	infection	infection	NN
cord-285262-690kpupt	441	1	(	(	-LRB-
cord-285262-690kpupt	441	2	Bandera	Bandera	NNP
cord-285262-690kpupt	441	3	et	et	NNP
cord-285262-690kpupt	441	4	al	al	NNP
cord-285262-690kpupt	441	5	.	.	NNP
cord-285262-690kpupt	441	6	,	,	,
cord-285262-690kpupt	441	7	2018	2018	CD
cord-285262-690kpupt	441	8	)	)	-RRB-
cord-285262-690kpupt	441	9	,	,	,
cord-285262-690kpupt	441	10	it	-PRON-	PRP
cord-285262-690kpupt	441	11	does	do	VBZ
cord-285262-690kpupt	441	12	not	not	RB
cord-285262-690kpupt	441	13	provide	provide	VB
cord-285262-690kpupt	441	14	direct	direct	JJ
cord-285262-690kpupt	441	15	evidence	evidence	NN
cord-285262-690kpupt	441	16	for	for	IN
cord-285262-690kpupt	441	17	an	an	DT
cord-285262-690kpupt	441	18	IFI16	ifi16	NN
cord-285262-690kpupt	441	19	driven	drive	VBN
cord-285262-690kpupt	441	20	pyroptotic	pyroptotic	JJ
cord-285262-690kpupt	441	21	cell	cell	NN
cord-285262-690kpupt	441	22	death	death	NN
cord-285262-690kpupt	441	23	.	.	.
cord-285262-690kpupt	442	1	AIM2	AIM2	NNP
cord-285262-690kpupt	442	2	has	have	VBZ
cord-285262-690kpupt	442	3	been	be	VBN
cord-285262-690kpupt	442	4	shown	show	VBN
cord-285262-690kpupt	442	5	to	to	TO
cord-285262-690kpupt	442	6	bind	bind	VB
cord-285262-690kpupt	442	7	DNA	DNA	NNP
cord-285262-690kpupt	442	8	and	and	CC
cord-285262-690kpupt	442	9	engage	engage	VB
cord-285262-690kpupt	442	10	the	the	DT
cord-285262-690kpupt	442	11	caspase-1-activating	caspase-1-activating	NN
cord-285262-690kpupt	442	12	adaptor	adaptor	NN
cord-285262-690kpupt	442	13	protein	protein	NN
cord-285262-690kpupt	442	14	ASC	ASC	NNP
cord-285262-690kpupt	442	15	to	to	TO
cord-285262-690kpupt	442	16	form	form	VB
cord-285262-690kpupt	442	17	an	an	DT
cord-285262-690kpupt	442	18	inflammasome	inflammasome	NN
cord-285262-690kpupt	442	19	.	.	.
cord-285262-690kpupt	443	1	AIM2	AIM2	NNP
cord-285262-690kpupt	443	2	conducts	conduct	VBZ
cord-285262-690kpupt	443	3	the	the	DT
cord-285262-690kpupt	443	4	maturation	maturation	NN
cord-285262-690kpupt	443	5	of	of	IN
cord-285262-690kpupt	443	6	IL-1β	il-1β	NN
cord-285262-690kpupt	443	7	/	/	,
cord-285262-690kpupt	443	8	IL-18	IL-18	NNP
cord-285262-690kpupt	443	9	and	and	CC
cord-285262-690kpupt	443	10	induces	induce	VBZ
cord-285262-690kpupt	443	11	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	443	12	in	in	IN
cord-285262-690kpupt	443	13	response	response	NN
cord-285262-690kpupt	443	14	to	to	IN
cord-285262-690kpupt	443	15	exposure	exposure	NN
cord-285262-690kpupt	443	16	of	of	IN
cord-285262-690kpupt	443	17	synthetic	synthetic	JJ
cord-285262-690kpupt	443	18	double	double	RB
cord-285262-690kpupt	443	19	-	-	HYPH
cord-285262-690kpupt	443	20	stranded	strand	VBN
cord-285262-690kpupt	443	21	DNA	dna	NN
cord-285262-690kpupt	443	22	(	(	-LRB-
cord-285262-690kpupt	443	23	Fig	fig	NN
cord-285262-690kpupt	443	24	.	.	.
cord-285262-690kpupt	443	25	3	3	CD
cord-285262-690kpupt	443	26	)	)	-RRB-
cord-285262-690kpupt	443	27	.	.	.
cord-285262-690kpupt	444	1	In	in	IN
cord-285262-690kpupt	444	2	natural	natural	JJ
cord-285262-690kpupt	444	3	situations	situation	NNS
cord-285262-690kpupt	444	4	,	,	,
cord-285262-690kpupt	444	5	AIM2	AIM2	NNP
cord-285262-690kpupt	444	6	dependent	dependent	JJ
cord-285262-690kpupt	444	7	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	444	8	is	be	VBZ
cord-285262-690kpupt	444	9	observed	observe	VBN
cord-285262-690kpupt	444	10	in	in	IN
cord-285262-690kpupt	444	11	response	response	NN
cord-285262-690kpupt	444	12	to	to	IN
cord-285262-690kpupt	444	13	MCMV	MCMV	NNP
cord-285262-690kpupt	444	14	,	,	,
cord-285262-690kpupt	444	15	Vaccinia	Vaccinia	NNP
cord-285262-690kpupt	444	16	virus	virus	NN
cord-285262-690kpupt	445	1	(	(	-LRB-
cord-285262-690kpupt	445	2	Rathinam	Rathinam	NNP
cord-285262-690kpupt	445	3	et	et	FW
cord-285262-690kpupt	445	4	al	al	NNP
cord-285262-690kpupt	445	5	.	.	NNP
cord-285262-690kpupt	445	6	,	,	,
cord-285262-690kpupt	445	7	2010	2010	CD
cord-285262-690kpupt	445	8	)	)	-RRB-
cord-285262-690kpupt	445	9	and	and	CC
cord-285262-690kpupt	445	10	EV71	EV71	NNP
cord-285262-690kpupt	445	11	infections	infection	NNS
cord-285262-690kpupt	446	1	(	(	-LRB-
cord-285262-690kpupt	446	2	Yogarajah	Yogarajah	NNP
cord-285262-690kpupt	446	3	et	et	NNP
cord-285262-690kpupt	446	4	al	al	NNP
cord-285262-690kpupt	446	5	.	.	NNP
cord-285262-690kpupt	446	6	,	,	,
cord-285262-690kpupt	446	7	2017	2017	CD
cord-285262-690kpupt	446	8	)	)	-RRB-
cord-285262-690kpupt	446	9	.	.	.
cord-285262-690kpupt	447	1	Zika	Zika	NNP
cord-285262-690kpupt	447	2	virus	virus	NN
cord-285262-690kpupt	447	3	(	(	-LRB-
cord-285262-690kpupt	447	4	ZIKV	ZIKV	NNP
cord-285262-690kpupt	447	5	)	)	-RRB-
cord-285262-690kpupt	447	6	,	,	,
cord-285262-690kpupt	447	7	an	an	DT
cord-285262-690kpupt	447	8	RNA	RNA	NNP
cord-285262-690kpupt	447	9	virus	virus	NN
cord-285262-690kpupt	447	10	,	,	,
cord-285262-690kpupt	447	11	has	have	VBZ
cord-285262-690kpupt	447	12	gained	gain	VBN
cord-285262-690kpupt	447	13	increased	increase	VBN
cord-285262-690kpupt	447	14	attention	attention	NN
cord-285262-690kpupt	447	15	over	over	IN
cord-285262-690kpupt	447	16	the	the	DT
cord-285262-690kpupt	447	17	last	last	JJ
cord-285262-690kpupt	447	18	years	year	NNS
cord-285262-690kpupt	447	19	due	due	IN
cord-285262-690kpupt	447	20	to	to	IN
cord-285262-690kpupt	447	21	its	-PRON-	PRP$
cord-285262-690kpupt	447	22	association	association	NN
cord-285262-690kpupt	447	23	with	with	IN
cord-285262-690kpupt	447	24	severe	severe	JJ
cord-285262-690kpupt	447	25	birth	birth	NN
cord-285262-690kpupt	447	26	defects	defect	NNS
cord-285262-690kpupt	447	27	,	,	,
cord-285262-690kpupt	447	28	including	include	VBG
cord-285262-690kpupt	447	29	microcephaly	microcephaly	NNS
cord-285262-690kpupt	447	30	.	.	.
cord-285262-690kpupt	448	1	Infection	infection	NN
cord-285262-690kpupt	448	2	with	with	IN
cord-285262-690kpupt	448	3	this	this	DT
cord-285262-690kpupt	448	4	flavivirus	flavivirus	NN
cord-285262-690kpupt	448	5	triggers	trigger	VBZ
cord-285262-690kpupt	448	6	higher	high	JJR
cord-285262-690kpupt	448	7	expression	expression	NN
cord-285262-690kpupt	448	8	levels	level	NNS
cord-285262-690kpupt	448	9	of	of	IN
cord-285262-690kpupt	448	10	NLRP1	NLRP1	NNP
cord-285262-690kpupt	448	11	,	,	,
cord-285262-690kpupt	448	12	3	3	CD
cord-285262-690kpupt	448	13	,	,	,
cord-285262-690kpupt	448	14	AIM2	AIM2	NNP
cord-285262-690kpupt	448	15	and	and	CC
cord-285262-690kpupt	448	16	caspase-1	caspase-1	NNP
cord-285262-690kpupt	448	17	in	in	IN
cord-285262-690kpupt	448	18	brain	brain	NN
cord-285262-690kpupt	448	19	tissues	tissue	NNS
cord-285262-690kpupt	448	20	collected	collect	VBN
cord-285262-690kpupt	448	21	from	from	IN
cord-285262-690kpupt	448	22	fatal	fatal	JJ
cord-285262-690kpupt	448	23	human	human	JJ
cord-285262-690kpupt	448	24	cases	case	NNS
cord-285262-690kpupt	448	25	(	(	-LRB-
cord-285262-690kpupt	448	26	de	de	FW
cord-285262-690kpupt	448	27	Sousa	Sousa	NNP
cord-285262-690kpupt	448	28	et	et	NNP
cord-285262-690kpupt	448	29	al	al	NNP
cord-285262-690kpupt	448	30	.	.	NNP
cord-285262-690kpupt	448	31	,	,	,
cord-285262-690kpupt	448	32	2018	2018	CD
cord-285262-690kpupt	448	33	)	)	-RRB-
cord-285262-690kpupt	448	34	.	.	.
cord-285262-690kpupt	449	1	It	-PRON-	PRP
cord-285262-690kpupt	449	2	is	be	VBZ
cord-285262-690kpupt	449	3	,	,	,
cord-285262-690kpupt	449	4	however	however	RB
cord-285262-690kpupt	449	5	,	,	,
cord-285262-690kpupt	449	6	not	not	RB
cord-285262-690kpupt	449	7	clear	clear	JJ
cord-285262-690kpupt	449	8	whether	whether	IN
cord-285262-690kpupt	449	9	the	the	DT
cord-285262-690kpupt	449	10	accompanied	accompany	VBN
cord-285262-690kpupt	449	11	brain	brain	NN
cord-285262-690kpupt	449	12	tissue	tissue	NN
cord-285262-690kpupt	449	13	damage	damage	NN
cord-285262-690kpupt	449	14	is	be	VBZ
cord-285262-690kpupt	449	15	the	the	DT
cord-285262-690kpupt	449	16	direct	direct	JJ
cord-285262-690kpupt	449	17	consequence	consequence	NN
cord-285262-690kpupt	449	18	of	of	IN
cord-285262-690kpupt	449	19	the	the	DT
cord-285262-690kpupt	449	20	GSDMD	GSDMD	NNP
cord-285262-690kpupt	449	21	driven	drive	VBN
cord-285262-690kpupt	449	22	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	449	23	or	or	CC
cord-285262-690kpupt	449	24	the	the	DT
cord-285262-690kpupt	449	25	detected	detect	VBN
cord-285262-690kpupt	449	26	higher	high	JJR
cord-285262-690kpupt	449	27	inflammasome	inflammasome	NN
cord-285262-690kpupt	449	28	expression	expression	NN
cord-285262-690kpupt	449	29	levels	level	NNS
cord-285262-690kpupt	449	30	represent	represent	VBP
cord-285262-690kpupt	449	31	a	a	DT
cord-285262-690kpupt	449	32	completely	completely	RB
cord-285262-690kpupt	449	33	unrelated	unrelated	JJ
cord-285262-690kpupt	449	34	phenomenon	phenomenon	NN
cord-285262-690kpupt	449	35	.	.	.
cord-285262-690kpupt	450	1	Virus	virus	NN
cord-285262-690kpupt	450	2	induced	induce	VBN
cord-285262-690kpupt	450	3	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	450	4	can	can	MD
cord-285262-690kpupt	450	5	be	be	VB
cord-285262-690kpupt	450	6	triggered	trigger	VBN
cord-285262-690kpupt	450	7	cell	cell	NN
cord-285262-690kpupt	450	8	type	type	NN
cord-285262-690kpupt	450	9	specifically	specifically	RB
cord-285262-690kpupt	450	10	for	for	IN
cord-285262-690kpupt	450	11	instance	instance	NN
cord-285262-690kpupt	450	12	in	in	IN
cord-285262-690kpupt	450	13	Rotavirus	Rotavirus	NNP
cord-285262-690kpupt	450	14	infection	infection	NN
cord-285262-690kpupt	450	15	,	,	,
cord-285262-690kpupt	450	16	a	a	DT
cord-285262-690kpupt	450	17	leading	leading	JJ
cord-285262-690kpupt	450	18	cause	cause	NN
cord-285262-690kpupt	450	19	of	of	IN
cord-285262-690kpupt	450	20	gastroenteritis	gastroenteritis	NN
cord-285262-690kpupt	450	21	and	and	CC
cord-285262-690kpupt	450	22	diarrhea	diarrhea	NN
cord-285262-690kpupt	450	23	in	in	IN
cord-285262-690kpupt	450	24	small	small	JJ
cord-285262-690kpupt	450	25	children	child	NNS
cord-285262-690kpupt	450	26	.	.	.
cord-285262-690kpupt	451	1	NLRP9	NLRP9	NNP
cord-285262-690kpupt	451	2	is	be	VBZ
cord-285262-690kpupt	451	3	a	a	DT
cord-285262-690kpupt	451	4	member	member	NN
cord-285262-690kpupt	451	5	of	of	IN
cord-285262-690kpupt	451	6	the	the	DT
cord-285262-690kpupt	451	7	NLR	NLR	NNP
cord-285262-690kpupt	451	8	family	family	NN
cord-285262-690kpupt	451	9	that	that	WDT
cord-285262-690kpupt	451	10	is	be	VBZ
cord-285262-690kpupt	451	11	specifically	specifically	RB
cord-285262-690kpupt	451	12	expressed	express	VBN
cord-285262-690kpupt	451	13	in	in	IN
cord-285262-690kpupt	451	14	intestinal	intestinal	JJ
cord-285262-690kpupt	451	15	epithelial	epithelial	JJ
cord-285262-690kpupt	451	16	cells	cell	NNS
cord-285262-690kpupt	451	17	in	in	IN
cord-285262-690kpupt	451	18	the	the	DT
cord-285262-690kpupt	451	19	site	site	NN
cord-285262-690kpupt	451	20	of	of	IN
cord-285262-690kpupt	451	21	the	the	DT
cord-285262-690kpupt	451	22	Rotavirus	Rotavirus	NNP
cord-285262-690kpupt	451	23	infection	infection	NN
cord-285262-690kpupt	451	24	.	.	.
cord-285262-690kpupt	452	1	NLRP9	NLRP9	NNP
cord-285262-690kpupt	452	2	can	can	MD
cord-285262-690kpupt	452	3	recognize	recognize	VB
cord-285262-690kpupt	452	4	dsRNA	dsrna	JJ
cord-285262-690kpupt	452	5	fragments	fragment	NNS
cord-285262-690kpupt	452	6	and	and	CC
cord-285262-690kpupt	452	7	form	form	VB
cord-285262-690kpupt	452	8	inflammasome	inflammasome	NNP
cord-285262-690kpupt	452	9	with	with	IN
cord-285262-690kpupt	452	10	ASC	ASC	NNP
cord-285262-690kpupt	452	11	to	to	TO
cord-285262-690kpupt	452	12	initiate	initiate	VB
cord-285262-690kpupt	452	13	caspase-1	caspase-1	NNP
cord-285262-690kpupt	452	14	cleavage	cleavage	NN
cord-285262-690kpupt	452	15	and	and	CC
cord-285262-690kpupt	452	16	GSDMD	GSDMD	NNP
cord-285262-690kpupt	452	17	driven	drive	VBN
cord-285262-690kpupt	452	18	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	452	19	(	(	-LRB-
cord-285262-690kpupt	452	20	Zhu	zhu	FW
cord-285262-690kpupt	452	21	et	et	FW
cord-285262-690kpupt	452	22	al	al	NNP
cord-285262-690kpupt	452	23	.	.	NNP
cord-285262-690kpupt	452	24	,	,	,
cord-285262-690kpupt	452	25	2017	2017	CD
cord-285262-690kpupt	452	26	)	)	-RRB-
cord-285262-690kpupt	452	27	.	.	.
cord-285262-690kpupt	453	1	Moreover	moreover	RB
cord-285262-690kpupt	453	2	,	,	,
cord-285262-690kpupt	453	3	Caspase-4	Caspase-4	NNP
cord-285262-690kpupt	453	4	,	,	,
cord-285262-690kpupt	453	5	the	the	DT
cord-285262-690kpupt	453	6	human	human	JJ
cord-285262-690kpupt	453	7	homolog	homolog	NN
cord-285262-690kpupt	453	8	of	of	IN
cord-285262-690kpupt	453	9	the	the	DT
cord-285262-690kpupt	453	10	mouse	mouse	NN
cord-285262-690kpupt	453	11	caspase-11	caspase-11	NNP
cord-285262-690kpupt	453	12	has	have	VBZ
cord-285262-690kpupt	453	13	been	be	VBN
cord-285262-690kpupt	453	14	reported	report	VBN
cord-285262-690kpupt	453	15	to	to	TO
cord-285262-690kpupt	453	16	function	function	VB
cord-285262-690kpupt	453	17	as	as	IN
cord-285262-690kpupt	453	18	a	a	DT
cord-285262-690kpupt	453	19	PAMP	PAMP	NNP
cord-285262-690kpupt	453	20	receptor	receptor	NN
cord-285262-690kpupt	453	21	.	.	.
cord-285262-690kpupt	454	1	In	in	IN
cord-285262-690kpupt	454	2	response	response	NN
cord-285262-690kpupt	454	3	to	to	IN
cord-285262-690kpupt	454	4	DV	DV	NNP
cord-285262-690kpupt	454	5	infection	infection	NN
cord-285262-690kpupt	454	6	,	,	,
cord-285262-690kpupt	454	7	caspase-4	caspase-4	NNP
cord-285262-690kpupt	454	8	is	be	VBZ
cord-285262-690kpupt	454	9	activated	activate	VBN
cord-285262-690kpupt	454	10	and	and	CC
cord-285262-690kpupt	454	11	can	can	MD
cord-285262-690kpupt	454	12	process	process	VB
cord-285262-690kpupt	454	13	caspase-1	caspase-1	NNP
cord-285262-690kpupt	455	1	in	in	IN
cord-285262-690kpupt	455	2	order	order	NN
cord-285262-690kpupt	455	3	to	to	TO
cord-285262-690kpupt	455	4	accomplish	accomplish	VB
cord-285262-690kpupt	455	5	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	455	6	(	(	-LRB-
cord-285262-690kpupt	455	7	Cheung	Cheung	NNP
cord-285262-690kpupt	455	8	et	et	NNP
cord-285262-690kpupt	455	9	al	al	NNP
cord-285262-690kpupt	455	10	.	.	NNP
cord-285262-690kpupt	455	11	,	,	,
cord-285262-690kpupt	455	12	2018	2018	CD
cord-285262-690kpupt	455	13	)	)	-RRB-
cord-285262-690kpupt	455	14	.	.	.
cord-285262-690kpupt	456	1	The	the	DT
cord-285262-690kpupt	456	2	first	first	JJ
cord-285262-690kpupt	456	3	report	report	NN
cord-285262-690kpupt	456	4	describing	describe	VBG
cord-285262-690kpupt	456	5	infection	infection	NN
cord-285262-690kpupt	456	6	driven	drive	VBN
cord-285262-690kpupt	456	7	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	456	8	was	be	VBD
cord-285262-690kpupt	456	9	performed	perform	VBN
cord-285262-690kpupt	456	10	in	in	IN
cord-285262-690kpupt	456	11	Salmonella	Salmonella	NNP
cord-285262-690kpupt	456	12	enterica	enterica	NNP
cord-285262-690kpupt	457	1	serovar	serovar	NNP
cord-285262-690kpupt	457	2	Typhimurium	Typhimurium	NNP
cord-285262-690kpupt	457	3	(	(	-LRB-
cord-285262-690kpupt	457	4	also	also	RB
cord-285262-690kpupt	457	5	called	call	VBN
cord-285262-690kpupt	457	6	Salmonella	Salmonella	NNP
cord-285262-690kpupt	457	7	typhimurium	typhimurium	NNP
cord-285262-690kpupt	457	8	)	)	-RRB-
cord-285262-690kpupt	457	9	infected	infect	VBN
cord-285262-690kpupt	457	10	mouse	mouse	NN
cord-285262-690kpupt	457	11	macrophages	macrophage	NNS
cord-285262-690kpupt	457	12	(	(	-LRB-
cord-285262-690kpupt	457	13	Fink	Fink	NNP
cord-285262-690kpupt	457	14	and	and	CC
cord-285262-690kpupt	457	15	Cookson	Cookson	NNP
cord-285262-690kpupt	457	16	,	,	,
cord-285262-690kpupt	457	17	2006	2006	CD
cord-285262-690kpupt	457	18	)	)	-RRB-
cord-285262-690kpupt	457	19	,	,	,
cord-285262-690kpupt	457	20	although	although	IN
cord-285262-690kpupt	457	21	caspase-1	caspase-1	NNP
cord-285262-690kpupt	457	22	dependent	dependent	JJ
cord-285262-690kpupt	457	23	cell	cell	NN
cord-285262-690kpupt	457	24	death	death	NN
cord-285262-690kpupt	457	25	in	in	IN
cord-285262-690kpupt	457	26	response	response	NN
cord-285262-690kpupt	457	27	to	to	IN
cord-285262-690kpupt	457	28	bacterial	bacterial	JJ
cord-285262-690kpupt	457	29	infection	infection	NN
cord-285262-690kpupt	457	30	was	be	VBD
cord-285262-690kpupt	457	31	mentioned	mention	VBN
cord-285262-690kpupt	457	32	in	in	IN
cord-285262-690kpupt	457	33	the	the	DT
cord-285262-690kpupt	457	34	literature	literature	NN
cord-285262-690kpupt	457	35	earlier	early	RBR
cord-285262-690kpupt	458	1	(	(	-LRB-
cord-285262-690kpupt	458	2	Chen	Chen	NNP
cord-285262-690kpupt	458	3	et	et	NNP
cord-285262-690kpupt	458	4	al	al	NNP
cord-285262-690kpupt	458	5	.	.	.
cord-285262-690kpupt	459	1	,	,	,
cord-285262-690kpupt	459	2	1996	1996	CD
cord-285262-690kpupt	459	3	;	;	:
cord-285262-690kpupt	459	4	Monack	Monack	NNP
cord-285262-690kpupt	459	5	et	et	FW
cord-285262-690kpupt	459	6	al	al	NNP
cord-285262-690kpupt	459	7	.	.	NNP
cord-285262-690kpupt	459	8	,	,	,
cord-285262-690kpupt	459	9	2001	2001	CD
cord-285262-690kpupt	459	10	)	)	-RRB-
cord-285262-690kpupt	459	11	.	.	.
cord-285262-690kpupt	460	1	The	the	DT
cord-285262-690kpupt	460	2	detection	detection	NN
cord-285262-690kpupt	460	3	of	of	IN
cord-285262-690kpupt	460	4	PAMPs	pamp	NNS
cord-285262-690kpupt	460	5	in	in	IN
cord-285262-690kpupt	460	6	bacterial	bacterial	JJ
cord-285262-690kpupt	460	7	infections	infection	NNS
cord-285262-690kpupt	460	8	includes	include	VBZ
cord-285262-690kpupt	460	9	the	the	DT
cord-285262-690kpupt	460	10	recognition	recognition	NN
cord-285262-690kpupt	460	11	of	of	IN
cord-285262-690kpupt	460	12	bacterial	bacterial	JJ
cord-285262-690kpupt	460	13	LPS	lp	NNS
cord-285262-690kpupt	460	14	,	,	,
cord-285262-690kpupt	460	15	flagellins	flagellin	NNS
cord-285262-690kpupt	460	16	,	,	,
cord-285262-690kpupt	460	17	components	component	NNS
cord-285262-690kpupt	460	18	of	of	IN
cord-285262-690kpupt	460	19	the	the	DT
cord-285262-690kpupt	460	20	bacterial	bacterial	JJ
cord-285262-690kpupt	460	21	T3SS	t3ss	NN
cord-285262-690kpupt	460	22	and	and	CC
cord-285262-690kpupt	460	23	the	the	DT
cord-285262-690kpupt	460	24	detection	detection	NN
cord-285262-690kpupt	460	25	of	of	IN
cord-285262-690kpupt	460	26	cytoplasmic	cytoplasmic	JJ
cord-285262-690kpupt	460	27	bacterial	bacterial	JJ
cord-285262-690kpupt	460	28	DNA	dna	NN
cord-285262-690kpupt	460	29	.	.	.
cord-285262-690kpupt	461	1	The	the	DT
cord-285262-690kpupt	461	2	components	component	NNS
cord-285262-690kpupt	461	3	of	of	IN
cord-285262-690kpupt	461	4	the	the	DT
cord-285262-690kpupt	461	5	bacterial	bacterial	JJ
cord-285262-690kpupt	461	6	T3SS	T3SS	NNP
cord-285262-690kpupt	461	7	trigger	trigger	NN
cord-285262-690kpupt	461	8	inflammasome	inflammasome	NN
cord-285262-690kpupt	461	9	formation	formation	NN
cord-285262-690kpupt	461	10	and	and	CC
cord-285262-690kpupt	461	11	pyroptotic	pyroptotic	JJ
cord-285262-690kpupt	461	12	cell	cell	NN
cord-285262-690kpupt	461	13	death	death	NN
cord-285262-690kpupt	461	14	in	in	IN
cord-285262-690kpupt	461	15	Shigella	Shigella	NNP
cord-285262-690kpupt	461	16	infected	infected	JJ
cord-285262-690kpupt	461	17	macrophages	macrophage	NNS
cord-285262-690kpupt	461	18	through	through	IN
cord-285262-690kpupt	461	19	the	the	DT
cord-285262-690kpupt	461	20	activation	activation	NN
cord-285262-690kpupt	461	21	of	of	IN
cord-285262-690kpupt	461	22	the	the	DT
cord-285262-690kpupt	461	23	NLR	NLR	NNP
cord-285262-690kpupt	461	24	family	family	NN
cord-285262-690kpupt	461	25	CARD	card	NN
cord-285262-690kpupt	461	26	domain	domain	NN
cord-285262-690kpupt	461	27	containing	contain	VBG
cord-285262-690kpupt	461	28	protein	protein	NN
cord-285262-690kpupt	461	29	4	4	CD
cord-285262-690kpupt	461	30	(	(	-LRB-
cord-285262-690kpupt	461	31	NLRC4	nlrc4	NN
cord-285262-690kpupt	461	32	)	)	-RRB-
cord-285262-690kpupt	462	1	(	(	-LRB-
cord-285262-690kpupt	462	2	Fig	Fig	NNP
cord-285262-690kpupt	462	3	.	.	.
cord-285262-690kpupt	462	4	3	3	CD
cord-285262-690kpupt	462	5	)	)	-RRB-
cord-285262-690kpupt	462	6	.	.	.
cord-285262-690kpupt	463	1	NLRC4	NLRC4	NNP
cord-285262-690kpupt	463	2	possess	possess	VBP
cord-285262-690kpupt	463	3	a	a	DT
cord-285262-690kpupt	463	4	CARD	card	NN
cord-285262-690kpupt	463	5	domain	domain	NN
cord-285262-690kpupt	463	6	,	,	,
cord-285262-690kpupt	463	7	therefore	therefore	RB
cord-285262-690kpupt	463	8	this	this	DT
cord-285262-690kpupt	463	9	NLR	NLR	NNP
cord-285262-690kpupt	463	10	family	family	NN
cord-285262-690kpupt	463	11	member	member	NN
cord-285262-690kpupt	463	12	can	can	MD
cord-285262-690kpupt	463	13	directly	directly	RB
cord-285262-690kpupt	463	14	engage	engage	VB
cord-285262-690kpupt	463	15	and	and	CC
cord-285262-690kpupt	463	16	process	process	VB
cord-285262-690kpupt	463	17	caspase-1	caspase-1	XX
cord-285262-690kpupt	464	1	(	(	-LRB-
cord-285262-690kpupt	464	2	Suzuki	Suzuki	NNP
cord-285262-690kpupt	464	3	et	et	FW
cord-285262-690kpupt	464	4	al	al	NNP
cord-285262-690kpupt	464	5	.	.	NNP
cord-285262-690kpupt	464	6	,	,	,
cord-285262-690kpupt	464	7	2007	2007	CD
cord-285262-690kpupt	464	8	)	)	-RRB-
cord-285262-690kpupt	464	9	.	.	.
cord-285262-690kpupt	465	1	Besides	besides	RB
cord-285262-690kpupt	465	2	,	,	,
cord-285262-690kpupt	465	3	flagellins	flagellin	NNS
cord-285262-690kpupt	465	4	of	of	IN
cord-285262-690kpupt	465	5	various	various	JJ
cord-285262-690kpupt	465	6	bacterial	bacterial	JJ
cord-285262-690kpupt	465	7	strains	strain	NNS
cord-285262-690kpupt	465	8	,	,	,
cord-285262-690kpupt	465	9	including	include	VBG
cord-285262-690kpupt	465	10	Listeria	Listeria	NNP
cord-285262-690kpupt	465	11	(	(	-LRB-
cord-285262-690kpupt	465	12	L.	L.	NNP
cord-285262-690kpupt	465	13	)	)	-RRB-
cord-285262-690kpupt	465	14	monocytogenes	monocytogenes	NNP
cord-285262-690kpupt	465	15	(	(	-LRB-
cord-285262-690kpupt	465	16	Cervantes	Cervantes	NNP
cord-285262-690kpupt	465	17	et	et	NNP
cord-285262-690kpupt	465	18	al	al	NNP
cord-285262-690kpupt	465	19	.	.	NNP
cord-285262-690kpupt	465	20	,	,	,
cord-285262-690kpupt	465	21	2008	2008	CD
cord-285262-690kpupt	465	22	;	;	:
cord-285262-690kpupt	465	23	Warren	Warren	NNP
cord-285262-690kpupt	465	24	et	et	NNP
cord-285262-690kpupt	465	25	al	al	NNP
cord-285262-690kpupt	465	26	.	.	NNP
cord-285262-690kpupt	465	27	,	,	,
cord-285262-690kpupt	465	28	2008	2008	CD
cord-285262-690kpupt	465	29	)	)	-RRB-
cord-285262-690kpupt	465	30	,	,	,
cord-285262-690kpupt	465	31	Legionella	Legionella	NNP
cord-285262-690kpupt	465	32	pneumophila	pneumophila	NN
cord-285262-690kpupt	465	33	and	and	CC
cord-285262-690kpupt	465	34	Burkholderia	Burkholderia	NNP
cord-285262-690kpupt	465	35	thailandensis	thailandensis	NN
cord-285262-690kpupt	466	1	(	(	-LRB-
cord-285262-690kpupt	466	2	Miao	Miao	NNP
cord-285262-690kpupt	466	3	et	et	NNP
cord-285262-690kpupt	466	4	al	al	NNP
cord-285262-690kpupt	466	5	.	.	NNP
cord-285262-690kpupt	466	6	,	,	,
cord-285262-690kpupt	466	7	2010	2010	CD
cord-285262-690kpupt	466	8	)	)	-RRB-
cord-285262-690kpupt	466	9	can	can	MD
cord-285262-690kpupt	466	10	lead	lead	VB
cord-285262-690kpupt	466	11	to	to	IN
cord-285262-690kpupt	466	12	the	the	DT
cord-285262-690kpupt	466	13	assembly	assembly	NN
cord-285262-690kpupt	466	14	of	of	IN
cord-285262-690kpupt	466	15	the	the	DT
cord-285262-690kpupt	466	16	NLRC4	NLRC4	NNP
cord-285262-690kpupt	466	17	inflammasome	inflammasome	NNP
cord-285262-690kpupt	467	1	(	(	-LRB-
cord-285262-690kpupt	467	2	Case	case	NN
cord-285262-690kpupt	467	3	et	et	FW
cord-285262-690kpupt	467	4	al	al	NNP
cord-285262-690kpupt	467	5	.	.	.
cord-285262-690kpupt	468	1	,	,	,
cord-285262-690kpupt	468	2	2009	2009	CD
cord-285262-690kpupt	468	3	)	)	-RRB-
cord-285262-690kpupt	468	4	.	.	.
cord-285262-690kpupt	469	1	The	the	DT
cord-285262-690kpupt	469	2	activation	activation	NN
cord-285262-690kpupt	469	3	of	of	IN
cord-285262-690kpupt	469	4	NLRC4	NLRC4	NNP
cord-285262-690kpupt	469	5	inflammasome	inflammasome	NNP
cord-285262-690kpupt	469	6	has	have	VBZ
cord-285262-690kpupt	469	7	been	be	VBN
cord-285262-690kpupt	469	8	shown	show	VBN
cord-285262-690kpupt	469	9	to	to	TO
cord-285262-690kpupt	469	10	lead	lead	VB
cord-285262-690kpupt	469	11	to	to	IN
cord-285262-690kpupt	469	12	bacterial	bacterial	JJ
cord-285262-690kpupt	469	13	clearance	clearance	NN
cord-285262-690kpupt	469	14	independent	independent	JJ
cord-285262-690kpupt	469	15	from	from	IN
cord-285262-690kpupt	469	16	the	the	DT
cord-285262-690kpupt	469	17	effect	effect	NN
cord-285262-690kpupt	469	18	of	of	IN
cord-285262-690kpupt	469	19	IL-1	IL-1	NNP
cord-285262-690kpupt	469	20	and	and	CC
cord-285262-690kpupt	469	21	IL-18	IL-18	NNP
cord-285262-690kpupt	469	22	production	production	NN
cord-285262-690kpupt	469	23	,	,	,
cord-285262-690kpupt	469	24	since	since	IN
cord-285262-690kpupt	469	25	this	this	DT
cord-285262-690kpupt	469	26	process	process	NN
cord-285262-690kpupt	469	27	functioned	function	VBD
cord-285262-690kpupt	469	28	efficiently	efficiently	RB
cord-285262-690kpupt	469	29	in	in	IN
cord-285262-690kpupt	469	30	IL-1/	IL-1/	NNP
cord-285262-690kpupt	469	31	IL-18	IL-18	NNP
cord-285262-690kpupt	469	32	knockout	knockout	NN
cord-285262-690kpupt	469	33	mice	mouse	NNS
cord-285262-690kpupt	469	34	(	(	-LRB-
cord-285262-690kpupt	469	35	Miao	Miao	NNP
cord-285262-690kpupt	469	36	et	et	NNP
cord-285262-690kpupt	469	37	al	al	NNP
cord-285262-690kpupt	469	38	.	.	NNP
cord-285262-690kpupt	469	39	,	,	,
cord-285262-690kpupt	469	40	2010	2010	CD
cord-285262-690kpupt	469	41	)	)	-RRB-
cord-285262-690kpupt	469	42	,	,	,
cord-285262-690kpupt	469	43	thus	thus	RB
cord-285262-690kpupt	469	44	implicating	implicate	VBG
cord-285262-690kpupt	469	45	the	the	DT
cord-285262-690kpupt	469	46	primary	primary	JJ
cord-285262-690kpupt	469	47	role	role	NN
cord-285262-690kpupt	469	48	of	of	IN
cord-285262-690kpupt	469	49	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	469	50	in	in	IN
cord-285262-690kpupt	469	51	the	the	DT
cord-285262-690kpupt	469	52	bacterial	bacterial	JJ
cord-285262-690kpupt	469	53	clearance	clearance	NN
cord-285262-690kpupt	469	54	.	.	.
cord-285262-690kpupt	470	1	This	this	DT
cord-285262-690kpupt	470	2	process	process	NN
cord-285262-690kpupt	470	3	involves	involve	VBZ
cord-285262-690kpupt	470	4	the	the	DT
cord-285262-690kpupt	470	5	pyroptotic	pyroptotic	JJ
cord-285262-690kpupt	470	6	release	release	NN
cord-285262-690kpupt	470	7	of	of	IN
cord-285262-690kpupt	470	8	the	the	DT
cord-285262-690kpupt	470	9	intracellular	intracellular	JJ
cord-285262-690kpupt	470	10	pathogens	pathogen	NNS
cord-285262-690kpupt	470	11	from	from	IN
cord-285262-690kpupt	470	12	the	the	DT
cord-285262-690kpupt	470	13	macrophages	macrophage	NNS
cord-285262-690kpupt	470	14	and	and	CC
cord-285262-690kpupt	470	15	leads	lead	VBZ
cord-285262-690kpupt	470	16	to	to	IN
cord-285262-690kpupt	470	17	the	the	DT
cord-285262-690kpupt	470	18	uptake	uptake	NN
cord-285262-690kpupt	470	19	of	of	IN
cord-285262-690kpupt	470	20	the	the	DT
cord-285262-690kpupt	470	21	bacteria	bacteria	NNS
cord-285262-690kpupt	470	22	by	by	IN
cord-285262-690kpupt	470	23	neutrophil	neutrophil	NN
cord-285262-690kpupt	470	24	granulocytes	granulocyte	NNS
cord-285262-690kpupt	470	25	.	.	.
cord-285262-690kpupt	471	1	In	in	IN
cord-285262-690kpupt	471	2	contrast	contrast	NN
cord-285262-690kpupt	471	3	,	,	,
cord-285262-690kpupt	471	4	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	471	5	can	can	MD
cord-285262-690kpupt	471	6	be	be	VB
cord-285262-690kpupt	471	7	also	also	RB
cord-285262-690kpupt	471	8	detrimental	detrimental	JJ
cord-285262-690kpupt	471	9	for	for	IN
cord-285262-690kpupt	471	10	the	the	DT
cord-285262-690kpupt	471	11	host	host	NN
cord-285262-690kpupt	471	12	organisms	organism	NNS
cord-285262-690kpupt	471	13	.	.	.
cord-285262-690kpupt	472	1	The	the	DT
cord-285262-690kpupt	472	2	extracellular	extracellular	JJ
cord-285262-690kpupt	472	3	opportunistic	opportunistic	JJ
cord-285262-690kpupt	472	4	pathogen	pathogen	NN
cord-285262-690kpupt	472	5	Pseudomonas	Pseudomonas	NNP
cord-285262-690kpupt	472	6	aeruginosa	aeruginosa	NN
cord-285262-690kpupt	472	7	infection	infection	NN
cord-285262-690kpupt	472	8	in	in	IN
cord-285262-690kpupt	472	9	mice	mouse	NNS
cord-285262-690kpupt	472	10	leads	lead	VBZ
cord-285262-690kpupt	472	11	to	to	IN
cord-285262-690kpupt	472	12	NLRC4	NLRC4	NNP
cord-285262-690kpupt	472	13	inflammasome	inflammasome	NNP
cord-285262-690kpupt	472	14	activation	activation	NN
cord-285262-690kpupt	472	15	,	,	,
cord-285262-690kpupt	472	16	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	472	17	and	and	CC
cord-285262-690kpupt	472	18	increased	increase	VBN
cord-285262-690kpupt	472	19	mortality	mortality	NN
cord-285262-690kpupt	472	20	,	,	,
cord-285262-690kpupt	472	21	whereas	whereas	IN
cord-285262-690kpupt	472	22	depletion	depletion	NN
cord-285262-690kpupt	472	23	of	of	IN
cord-285262-690kpupt	472	24	NLRC4	nlrc4	NN
cord-285262-690kpupt	472	25	results	result	NNS
cord-285262-690kpupt	472	26	in	in	IN
cord-285262-690kpupt	472	27	improved	improve	VBN
cord-285262-690kpupt	472	28	bacterial	bacterial	JJ
cord-285262-690kpupt	472	29	clearance	clearance	NN
cord-285262-690kpupt	472	30	and	and	CC
cord-285262-690kpupt	472	31	increased	increase	VBN
cord-285262-690kpupt	472	32	survival	survival	NN
cord-285262-690kpupt	472	33	(	(	-LRB-
cord-285262-690kpupt	472	34	Cohen	Cohen	NNP
cord-285262-690kpupt	472	35	and	and	CC
cord-285262-690kpupt	472	36	Prince	Prince	NNP
cord-285262-690kpupt	472	37	,	,	,
cord-285262-690kpupt	472	38	2013	2013	CD
cord-285262-690kpupt	472	39	)	)	-RRB-
cord-285262-690kpupt	472	40	.	.	.
cord-285262-690kpupt	473	1	The	the	DT
cord-285262-690kpupt	473	2	NLRC4	NLRC4	NNP
cord-285262-690kpupt	473	3	inflammasome	inflammasome	NN
cord-285262-690kpupt	473	4	utilizes	utilize	VBZ
cord-285262-690kpupt	473	5	various	various	JJ
cord-285262-690kpupt	473	6	sensors	sensor	NNS
cord-285262-690kpupt	473	7	in	in	IN
cord-285262-690kpupt	473	8	order	order	NN
cord-285262-690kpupt	473	9	to	to	TO
cord-285262-690kpupt	473	10	recognize	recognize	VB
cord-285262-690kpupt	473	11	PAMPs	pamp	NNS
cord-285262-690kpupt	473	12	.	.	.
cord-285262-690kpupt	474	1	The	the	DT
cord-285262-690kpupt	474	2	human	human	JJ
cord-285262-690kpupt	474	3	NLR	NLR	NNP
cord-285262-690kpupt	474	4	family	family	NN
cord-285262-690kpupt	474	5	apoptosis	apoptosis	VB
cord-285262-690kpupt	474	6	inhibitory	inhibitory	JJ
cord-285262-690kpupt	474	7	protein	protein	NN
cord-285262-690kpupt	474	8	2	2	CD
cord-285262-690kpupt	474	9	(	(	-LRB-
cord-285262-690kpupt	474	10	NAIP2	NAIP2	NNP
cord-285262-690kpupt	474	11	)	)	-RRB-
cord-285262-690kpupt	474	12	and	and	CC
cord-285262-690kpupt	474	13	the	the	DT
cord-285262-690kpupt	474	14	mouse	mouse	NN
cord-285262-690kpupt	474	15	counterpart	counterpart	NN
cord-285262-690kpupt	474	16	Naip5	naip5	NN
cord-285262-690kpupt	474	17	prevent	prevent	VB
cord-285262-690kpupt	474	18	apoptosis	apoptosis	NN
cord-285262-690kpupt	474	19	by	by	IN
cord-285262-690kpupt	474	20	inhibiting	inhibit	VBG
cord-285262-690kpupt	474	21	caspases	caspase	NNS
cord-285262-690kpupt	474	22	.	.	.
cord-285262-690kpupt	475	1	The	the	DT
cord-285262-690kpupt	475	2	flagellin	flagellin	NN
cord-285262-690kpupt	475	3	of	of	IN
cord-285262-690kpupt	475	4	the	the	DT
cord-285262-690kpupt	475	5	Legionella	Legionella	NNP
cord-285262-690kpupt	475	6	pneumophila	pneumophila	NN
cord-285262-690kpupt	475	7	can	can	MD
cord-285262-690kpupt	475	8	result	result	VB
cord-285262-690kpupt	475	9	in	in	IN
cord-285262-690kpupt	475	10	caspase-1	caspase-1	NNP
cord-285262-690kpupt	475	11	activation	activation	NN
cord-285262-690kpupt	475	12	and	and	CC
cord-285262-690kpupt	475	13	cell	cell	NN
cord-285262-690kpupt	475	14	death	death	NN
cord-285262-690kpupt	475	15	in	in	IN
cord-285262-690kpupt	475	16	a	a	DT
cord-285262-690kpupt	475	17	NAIP2	naip2	NN
cord-285262-690kpupt	475	18	dependent	dependent	JJ
cord-285262-690kpupt	475	19	manner	manner	NN
cord-285262-690kpupt	475	20	in	in	IN
cord-285262-690kpupt	475	21	macrophages	macrophage	NNS
cord-285262-690kpupt	475	22	(	(	-LRB-
cord-285262-690kpupt	475	23	Fig	Fig	NNP
cord-285262-690kpupt	475	24	.	.	.
cord-285262-690kpupt	475	25	3	3	CD
cord-285262-690kpupt	475	26	)	)	-RRB-
cord-285262-690kpupt	476	1	(	(	-LRB-
cord-285262-690kpupt	476	2	Katagiri	Katagiri	NNP
cord-285262-690kpupt	476	3	et	et	NNP
cord-285262-690kpupt	476	4	al	al	NNP
cord-285262-690kpupt	476	5	.	.	NNP
cord-285262-690kpupt	476	6	,	,	,
cord-285262-690kpupt	476	7	2012	2012	CD
cord-285262-690kpupt	476	8	)	)	-RRB-
cord-285262-690kpupt	476	9	.	.	.
cord-285262-690kpupt	477	1	Importantly	importantly	RB
cord-285262-690kpupt	477	2	,	,	,
cord-285262-690kpupt	477	3	not	not	RB
cord-285262-690kpupt	477	4	all	all	DT
cord-285262-690kpupt	477	5	bacterial	bacterial	JJ
cord-285262-690kpupt	477	6	strains	strain	NNS
cord-285262-690kpupt	477	7	express	express	VBP
cord-285262-690kpupt	477	8	flagellins	flagellins	NNP
cord-285262-690kpupt	477	9	constantly	constantly	RB
cord-285262-690kpupt	477	10	.	.	.
cord-285262-690kpupt	478	1	Nevertheless	nevertheless	RB
cord-285262-690kpupt	478	2	,	,	,
cord-285262-690kpupt	478	3	the	the	DT
cord-285262-690kpupt	478	4	inner	inner	JJ
cord-285262-690kpupt	478	5	rod	rod	NN
cord-285262-690kpupt	478	6	of	of	IN
cord-285262-690kpupt	478	7	the	the	DT
cord-285262-690kpupt	478	8	T3SS	T3SS	NNP
cord-285262-690kpupt	478	9	needle	needle	NN
cord-285262-690kpupt	478	10	complex	complex	NN
cord-285262-690kpupt	478	11	of	of	IN
cord-285262-690kpupt	478	12	the	the	DT
cord-285262-690kpupt	478	13	non	non	JJ
cord-285262-690kpupt	478	14	-	-	JJ
cord-285262-690kpupt	478	15	flagellated	flagellated	JJ
cord-285262-690kpupt	478	16	Shigella	Shigella	NNP
cord-285262-690kpupt	478	17	bacteria	bacteria	NNS
cord-285262-690kpupt	478	18	results	result	NNS
cord-285262-690kpupt	478	19	in	in	IN
cord-285262-690kpupt	478	20	the	the	DT
cord-285262-690kpupt	478	21	engagement	engagement	NN
cord-285262-690kpupt	478	22	of	of	IN
cord-285262-690kpupt	478	23	mouse	mouse	NN
cord-285262-690kpupt	478	24	Naip2	naip2	JJ
cord-285262-690kpupt	478	25	and	and	CC
cord-285262-690kpupt	478	26	leads	lead	VBZ
cord-285262-690kpupt	478	27	to	to	IN
cord-285262-690kpupt	478	28	the	the	DT
cord-285262-690kpupt	478	29	NLRC4	NLRC4	NNP
cord-285262-690kpupt	478	30	inflammasome	inflammasome	NNP
cord-285262-690kpupt	478	31	mediated	mediate	VBD
cord-285262-690kpupt	478	32	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	478	33	in	in	IN
cord-285262-690kpupt	478	34	primary	primary	JJ
cord-285262-690kpupt	478	35	mouse	mouse	NN
cord-285262-690kpupt	478	36	macrophages	macrophage	NNS
cord-285262-690kpupt	478	37	(	(	-LRB-
cord-285262-690kpupt	478	38	Suzuki	Suzuki	NNP
cord-285262-690kpupt	478	39	et	et	FW
cord-285262-690kpupt	478	40	al	al	NNP
cord-285262-690kpupt	478	41	.	.	NNP
cord-285262-690kpupt	478	42	,	,	,
cord-285262-690kpupt	478	43	2014	2014	CD
cord-285262-690kpupt	478	44	)	)	-RRB-
cord-285262-690kpupt	478	45	.	.	.
cord-285262-690kpupt	479	1	The	the	DT
cord-285262-690kpupt	479	2	hNAIP	hnaip	NN
cord-285262-690kpupt	479	3	and	and	CC
cord-285262-690kpupt	479	4	the	the	DT
cord-285262-690kpupt	479	5	mouse	mouse	NN
cord-285262-690kpupt	479	6	counterpart	counterpart	NN
cord-285262-690kpupt	479	7	Naip1	Naip1	NNP
cord-285262-690kpupt	480	1	(	(	-LRB-
cord-285262-690kpupt	480	2	Fig	Fig	NNP
cord-285262-690kpupt	480	3	.	.	.
cord-285262-690kpupt	481	1	3	3	LS
cord-285262-690kpupt	481	2	)	)	-RRB-
cord-285262-690kpupt	481	3	can	can	MD
cord-285262-690kpupt	481	4	recognize	recognize	VB
cord-285262-690kpupt	481	5	the	the	DT
cord-285262-690kpupt	481	6	needle	needle	NN
cord-285262-690kpupt	481	7	component	component	NN
cord-285262-690kpupt	481	8	of	of	IN
cord-285262-690kpupt	481	9	the	the	DT
cord-285262-690kpupt	481	10	Salmonella	Salmonella	NNP
cord-285262-690kpupt	481	11	T3SS	T3SS	NNP
cord-285262-690kpupt	481	12	in	in	IN
cord-285262-690kpupt	481	13	dendritic	dendritic	JJ
cord-285262-690kpupt	481	14	cells	cell	NNS
cord-285262-690kpupt	481	15	,	,	,
cord-285262-690kpupt	481	16	and	and	CC
cord-285262-690kpupt	481	17	to	to	TO
cord-285262-690kpupt	481	18	less	less	JJR
cord-285262-690kpupt	481	19	extent	extent	NN
cord-285262-690kpupt	481	20	in	in	IN
cord-285262-690kpupt	481	21	macrophages	macrophage	NNS
cord-285262-690kpupt	481	22	.	.	.
cord-285262-690kpupt	482	1	NLRC4	NLRC4	NNP
cord-285262-690kpupt	482	2	activation	activation	NN
cord-285262-690kpupt	482	3	is	be	VBZ
cord-285262-690kpupt	482	4	mediated	mediate	VBN
cord-285262-690kpupt	482	5	by	by	IN
cord-285262-690kpupt	482	6	NAIP	NAIP	NNP
cord-285262-690kpupt	482	7	independent	independent	JJ
cord-285262-690kpupt	482	8	phosphorylation	phosphorylation	NN
cord-285262-690kpupt	482	9	events	event	NNS
cord-285262-690kpupt	482	10	,	,	,
cord-285262-690kpupt	482	11	which	which	WDT
cord-285262-690kpupt	482	12	suggest	suggest	VBP
cord-285262-690kpupt	482	13	a	a	DT
cord-285262-690kpupt	482	14	biphasic	biphasic	JJ
cord-285262-690kpupt	482	15	model	model	NN
cord-285262-690kpupt	482	16	for	for	IN
cord-285262-690kpupt	482	17	the	the	DT
cord-285262-690kpupt	482	18	stimulation	stimulation	NN
cord-285262-690kpupt	482	19	of	of	IN
cord-285262-690kpupt	482	20	this	this	DT
cord-285262-690kpupt	482	21	intracellular	intracellular	JJ
cord-285262-690kpupt	482	22	pathogen	pathogen	NN
cord-285262-690kpupt	482	23	sensor	sensor	NN
cord-285262-690kpupt	482	24	(	(	-LRB-
cord-285262-690kpupt	482	25	Matusiak	Matusiak	NNP
cord-285262-690kpupt	482	26	et	et	NNP
cord-285262-690kpupt	482	27	al	al	NNP
cord-285262-690kpupt	482	28	.	.	NNP
cord-285262-690kpupt	482	29	,	,	,
cord-285262-690kpupt	482	30	2015	2015	CD
cord-285262-690kpupt	482	31	;	;	:
cord-285262-690kpupt	482	32	Qu	Qu	NNP
cord-285262-690kpupt	482	33	et	et	NNP
cord-285262-690kpupt	482	34	al	al	NNP
cord-285262-690kpupt	482	35	.	.	NNP
cord-285262-690kpupt	482	36	,	,	,
cord-285262-690kpupt	482	37	2012	2012	CD
cord-285262-690kpupt	482	38	)	)	-RRB-
cord-285262-690kpupt	482	39	.	.	.
cord-285262-690kpupt	483	1	The	the	DT
cord-285262-690kpupt	483	2	existence	existence	NN
cord-285262-690kpupt	483	3	of	of	IN
cord-285262-690kpupt	483	4	a	a	DT
cord-285262-690kpupt	483	5	second	second	JJ
cord-285262-690kpupt	483	6	stimulatory	stimulatory	JJ
cord-285262-690kpupt	483	7	signal	signal	NN
cord-285262-690kpupt	483	8	is	be	VBZ
cord-285262-690kpupt	483	9	further	further	RB
cord-285262-690kpupt	483	10	supported	support	VBN
cord-285262-690kpupt	483	11	by	by	IN
cord-285262-690kpupt	483	12	the	the	DT
cord-285262-690kpupt	483	13	observations	observation	NNS
cord-285262-690kpupt	483	14	on	on	IN
cord-285262-690kpupt	483	15	the	the	DT
cord-285262-690kpupt	483	16	T3SS	t3ss	NN
cord-285262-690kpupt	484	1	effector	effector	NNP
cord-285262-690kpupt	484	2	protein	protein	NN
cord-285262-690kpupt	484	3	YopJ	YopJ	NNP
cord-285262-690kpupt	484	4	of	of	IN
cord-285262-690kpupt	484	5	the	the	DT
cord-285262-690kpupt	484	6	Yersinia	Yersinia	NNP
cord-285262-690kpupt	484	7	pestis	pestis	NN
cord-285262-690kpupt	484	8	,	,	,
cord-285262-690kpupt	484	9	which	which	WDT
cord-285262-690kpupt	484	10	translocates	translocate	VBZ
cord-285262-690kpupt	484	11	into	into	IN
cord-285262-690kpupt	484	12	the	the	DT
cord-285262-690kpupt	484	13	cytoplasm	cytoplasm	NN
cord-285262-690kpupt	484	14	upon	upon	IN
cord-285262-690kpupt	484	15	infection	infection	NN
cord-285262-690kpupt	484	16	and	and	CC
cord-285262-690kpupt	484	17	induces	induce	VBZ
cord-285262-690kpupt	484	18	a	a	DT
cord-285262-690kpupt	484	19	rapid	rapid	JJ
cord-285262-690kpupt	484	20	apoptosis	apoptosis	NN
cord-285262-690kpupt	484	21	in	in	IN
cord-285262-690kpupt	484	22	macrophages	macrophage	NNS
cord-285262-690kpupt	484	23	.	.	.
cord-285262-690kpupt	485	1	In	in	IN
cord-285262-690kpupt	485	2	contrast	contrast	NN
cord-285262-690kpupt	485	3	,	,	,
cord-285262-690kpupt	485	4	a	a	DT
cord-285262-690kpupt	485	5	preceding	precede	VBG
cord-285262-690kpupt	485	6	activation	activation	NN
cord-285262-690kpupt	485	7	by	by	IN
cord-285262-690kpupt	485	8	LPS	LPS	NNP
cord-285262-690kpupt	485	9	or	or	CC
cord-285262-690kpupt	485	10	by	by	IN
cord-285262-690kpupt	485	11	the	the	DT
cord-285262-690kpupt	485	12	ligation	ligation	NN
cord-285262-690kpupt	485	13	of	of	IN
cord-285262-690kpupt	485	14	the	the	DT
cord-285262-690kpupt	485	15	PRRs	PRRs	NNP
cord-285262-690kpupt	485	16	TLR2	TLR2	NNP
cord-285262-690kpupt	485	17	,	,	,
cord-285262-690kpupt	485	18	3	3	CD
cord-285262-690kpupt	485	19	and	and	CC
cord-285262-690kpupt	485	20	4	4	CD
cord-285262-690kpupt	485	21	leads	lead	VBZ
cord-285262-690kpupt	485	22	to	to	IN
cord-285262-690kpupt	485	23	a	a	DT
cord-285262-690kpupt	485	24	YopJ	YopJ	NNP
cord-285262-690kpupt	485	25	independent	independent	JJ
cord-285262-690kpupt	485	26	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	485	27	(	(	-LRB-
cord-285262-690kpupt	485	28	Bergsbaken	Bergsbaken	NNP
cord-285262-690kpupt	485	29	and	and	CC
cord-285262-690kpupt	485	30	Cookson	Cookson	NNP
cord-285262-690kpupt	485	31	,	,	,
cord-285262-690kpupt	485	32	2007	2007	CD
cord-285262-690kpupt	485	33	)	)	-RRB-
cord-285262-690kpupt	485	34	.	.	.
cord-285262-690kpupt	486	1	Furthermore	furthermore	RB
cord-285262-690kpupt	486	2	,	,	,
cord-285262-690kpupt	486	3	interferon	interferon	NN
cord-285262-690kpupt	486	4	regulatory	regulatory	JJ
cord-285262-690kpupt	486	5	factor	factor	NN
cord-285262-690kpupt	486	6	8	8	CD
cord-285262-690kpupt	486	7	(	(	-LRB-
cord-285262-690kpupt	486	8	IRF8	IRF8	NNP
cord-285262-690kpupt	486	9	)	)	-RRB-
cord-285262-690kpupt	486	10	is	be	VBZ
cord-285262-690kpupt	486	11	required	require	VBN
cord-285262-690kpupt	486	12	for	for	IN
cord-285262-690kpupt	486	13	the	the	DT
cord-285262-690kpupt	486	14	activation	activation	NN
cord-285262-690kpupt	486	15	of	of	IN
cord-285262-690kpupt	486	16	the	the	DT
cord-285262-690kpupt	486	17	NLRC4	NLRC4	NNP
cord-285262-690kpupt	486	18	inflammasome	inflammasome	NN
cord-285262-690kpupt	486	19	in	in	IN
cord-285262-690kpupt	486	20	bone	bone	NN
cord-285262-690kpupt	486	21	marrow	marrow	NN
cord-285262-690kpupt	486	22	-	-	HYPH
cord-285262-690kpupt	486	23	derived	derive	VBN
cord-285262-690kpupt	486	24	macrophages	macrophage	NNS
cord-285262-690kpupt	486	25	infected	infect	VBN
cord-285262-690kpupt	486	26	with	with	IN
cord-285262-690kpupt	486	27	Salmonella	Salmonella	NNP
cord-285262-690kpupt	486	28	typhimurium	typhimurium	NN
cord-285262-690kpupt	486	29	,	,	,
cord-285262-690kpupt	486	30	Burkholderia	Burkholderia	NNP
cord-285262-690kpupt	486	31	thailandensis	thailandensis	NN
cord-285262-690kpupt	486	32	and	and	CC
cord-285262-690kpupt	486	33	Pseudomonas	Pseudomonas	NNP
cord-285262-690kpupt	486	34	aeruginosa	aeruginosa	NN
cord-285262-690kpupt	486	35	.	.	.
cord-285262-690kpupt	487	1	In	in	IN
cord-285262-690kpupt	487	2	these	these	DT
cord-285262-690kpupt	487	3	infections	infection	NNS
cord-285262-690kpupt	487	4	,	,	,
cord-285262-690kpupt	487	5	IRF8	IRF8	NNP
cord-285262-690kpupt	487	6	conducts	conduct	VBZ
cord-285262-690kpupt	487	7	the	the	DT
cord-285262-690kpupt	487	8	transcription	transcription	NN
cord-285262-690kpupt	487	9	of	of	IN
cord-285262-690kpupt	487	10	the	the	DT
cord-285262-690kpupt	487	11	NAIPs	naip	NNS
cord-285262-690kpupt	488	1	(	(	-LRB-
cord-285262-690kpupt	488	2	Karki	Karki	NNP
cord-285262-690kpupt	488	3	et	et	NNP
cord-285262-690kpupt	488	4	al	al	NNP
cord-285262-690kpupt	488	5	.	.	NNP
cord-285262-690kpupt	488	6	,	,	,
cord-285262-690kpupt	488	7	2018	2018	CD
cord-285262-690kpupt	488	8	)	)	-RRB-
cord-285262-690kpupt	488	9	.	.	.
cord-285262-690kpupt	489	1	These	these	DT
cord-285262-690kpupt	489	2	results	result	NNS
cord-285262-690kpupt	489	3	implicate	implicate	VBP
cord-285262-690kpupt	489	4	that	that	IN
cord-285262-690kpupt	489	5	the	the	DT
cord-285262-690kpupt	489	6	activation	activation	NN
cord-285262-690kpupt	489	7	of	of	IN
cord-285262-690kpupt	489	8	NLRC4	NLRC4	NNP
cord-285262-690kpupt	489	9	relies	rely	VBZ
cord-285262-690kpupt	489	10	on	on	IN
cord-285262-690kpupt	489	11	a	a	DT
cord-285262-690kpupt	489	12	second	second	JJ
cord-285262-690kpupt	489	13	PAMP	pamp	NN
cord-285262-690kpupt	489	14	signal	signal	NN
cord-285262-690kpupt	489	15	,	,	,
cord-285262-690kpupt	489	16	which	which	WDT
cord-285262-690kpupt	489	17	then	then	RB
cord-285262-690kpupt	489	18	initiate	initiate	VBP
cord-285262-690kpupt	489	19	transcriptional	transcriptional	JJ
cord-285262-690kpupt	489	20	priming	priming	NN
cord-285262-690kpupt	489	21	and	and	CC
cord-285262-690kpupt	489	22	can	can	MD
cord-285262-690kpupt	489	23	mediate	mediate	VB
cord-285262-690kpupt	489	24	further	further	JJ
cord-285262-690kpupt	489	25	stimulatory	stimulatory	JJ
cord-285262-690kpupt	489	26	phosphorylation	phosphorylation	NN
cord-285262-690kpupt	489	27	steps	step	NNS
cord-285262-690kpupt	489	28	.	.	.
cord-285262-690kpupt	490	1	4.3.2	4.3.2	LS
cord-285262-690kpupt	491	1	The	the	DT
cord-285262-690kpupt	491	2	NLRP3	nlrp3	NN
cord-285262-690kpupt	491	3	inflammasome	inflammasome	NN
cord-285262-690kpupt	491	4	NLRP3	nlrp3	NN
cord-285262-690kpupt	491	5	indirectly	indirectly	RB
cord-285262-690kpupt	491	6	senses	sense	VBZ
cord-285262-690kpupt	491	7	pathogen	pathogen	NN
cord-285262-690kpupt	491	8	associated	associate	VBD
cord-285262-690kpupt	491	9	signals	signal	NNS
cord-285262-690kpupt	491	10	such	such	JJ
cord-285262-690kpupt	491	11	as	as	IN
cord-285262-690kpupt	491	12	extracellular	extracellular	JJ
cord-285262-690kpupt	491	13	ATP	ATP	NNP
cord-285262-690kpupt	491	14	and	and	CC
cord-285262-690kpupt	491	15	uric	uric	NN
cord-285262-690kpupt	491	16	acid	acid	NN
cord-285262-690kpupt	491	17	crystals	crystal	NNS
cord-285262-690kpupt	491	18	(	(	-LRB-
cord-285262-690kpupt	491	19	Martinon	Martinon	NNP
cord-285262-690kpupt	491	20	et	et	NNP
cord-285262-690kpupt	491	21	al	al	NNP
cord-285262-690kpupt	491	22	.	.	NNP
cord-285262-690kpupt	491	23	,	,	,
cord-285262-690kpupt	491	24	2006	2006	CD
cord-285262-690kpupt	491	25	)	)	-RRB-
cord-285262-690kpupt	491	26	,	,	,
cord-285262-690kpupt	491	27	which	which	WDT
cord-285262-690kpupt	491	28	then	then	RB
cord-285262-690kpupt	491	29	leads	lead	VBZ
cord-285262-690kpupt	491	30	to	to	IN
cord-285262-690kpupt	491	31	a	a	DT
cord-285262-690kpupt	491	32	conformational	conformational	JJ
cord-285262-690kpupt	491	33	change	change	NN
cord-285262-690kpupt	491	34	,	,	,
cord-285262-690kpupt	491	35	resulting	result	VBG
cord-285262-690kpupt	491	36	in	in	IN
cord-285262-690kpupt	491	37	the	the	DT
cord-285262-690kpupt	491	38	binding	binding	NN
cord-285262-690kpupt	491	39	and	and	CC
cord-285262-690kpupt	491	40	the	the	DT
cord-285262-690kpupt	491	41	oligomerization	oligomerization	NN
cord-285262-690kpupt	491	42	of	of	IN
cord-285262-690kpupt	491	43	the	the	DT
cord-285262-690kpupt	491	44	adaptor	adaptor	NN
cord-285262-690kpupt	491	45	molecule	molecule	NN
cord-285262-690kpupt	491	46	ASC	ASC	NNP
cord-285262-690kpupt	491	47	.	.	.
cord-285262-690kpupt	492	1	Bacterial	bacterial	JJ
cord-285262-690kpupt	492	2	PFTs	pft	NNS
cord-285262-690kpupt	492	3	,	,	,
cord-285262-690kpupt	492	4	including	include	VBG
cord-285262-690kpupt	492	5	the	the	DT
cord-285262-690kpupt	492	6	hemolysin	hemolysin	NN
cord-285262-690kpupt	492	7	of	of	IN
cord-285262-690kpupt	492	8	the	the	DT
cord-285262-690kpupt	492	9	bacteria	bacteria	NNS
cord-285262-690kpupt	492	10	Vibrio	Vibrio	NNP
cord-285262-690kpupt	492	11	cholerae	cholerae	NN
cord-285262-690kpupt	492	12	,	,	,
cord-285262-690kpupt	492	13	or	or	CC
cord-285262-690kpupt	492	14	the	the	DT
cord-285262-690kpupt	492	15	M	M	NNP
cord-285262-690kpupt	492	16	surface	surface	NN
cord-285262-690kpupt	492	17	protein	protein	NN
cord-285262-690kpupt	492	18	of	of	IN
cord-285262-690kpupt	492	19	the	the	DT
cord-285262-690kpupt	492	20	group	group	NN
cord-285262-690kpupt	493	1	A	a	DT
cord-285262-690kpupt	493	2	Streptococcus	streptococcus	NN
cord-285262-690kpupt	493	3	can	can	MD
cord-285262-690kpupt	493	4	efficiently	efficiently	RB
cord-285262-690kpupt	493	5	induce	induce	VB
cord-285262-690kpupt	493	6	potassium	potassium	NN
cord-285262-690kpupt	493	7	efflux	efflux	NN
cord-285262-690kpupt	493	8	,	,	,
cord-285262-690kpupt	493	9	which	which	WDT
cord-285262-690kpupt	493	10	has	have	VBZ
cord-285262-690kpupt	493	11	been	be	VBN
cord-285262-690kpupt	493	12	defined	define	VBN
cord-285262-690kpupt	493	13	as	as	IN
cord-285262-690kpupt	493	14	the	the	DT
cord-285262-690kpupt	493	15	unified	unified	JJ
cord-285262-690kpupt	493	16	trigger	trigger	NN
cord-285262-690kpupt	493	17	of	of	IN
cord-285262-690kpupt	493	18	the	the	DT
cord-285262-690kpupt	493	19	NLRP3	NLRP3	NNP
cord-285262-690kpupt	493	20	inflammasome	inflammasome	NNP
cord-285262-690kpupt	493	21	activation	activation	NN
cord-285262-690kpupt	493	22	(	(	-LRB-
cord-285262-690kpupt	493	23	Muñoz	Muñoz	NNP
cord-285262-690kpupt	493	24	-	-	HYPH
cord-285262-690kpupt	493	25	Planillo	Planillo	NNP
cord-285262-690kpupt	493	26	et	et	NNP
cord-285262-690kpupt	493	27	al	al	NNP
cord-285262-690kpupt	493	28	.	.	NNP
cord-285262-690kpupt	493	29	,	,	,
cord-285262-690kpupt	493	30	2013	2013	CD
cord-285262-690kpupt	493	31	;	;	:
cord-285262-690kpupt	493	32	Queen	Queen	NNP
cord-285262-690kpupt	493	33	et	et	NNP
cord-285262-690kpupt	493	34	al	al	NNP
cord-285262-690kpupt	493	35	.	.	NNP
cord-285262-690kpupt	493	36	,	,	,
cord-285262-690kpupt	493	37	2015	2015	CD
cord-285262-690kpupt	493	38	;	;	:
cord-285262-690kpupt	493	39	Valderrama	Valderrama	NNP
cord-285262-690kpupt	493	40	et	et	NNP
cord-285262-690kpupt	493	41	al	al	NNP
cord-285262-690kpupt	493	42	.	.	NNP
cord-285262-690kpupt	493	43	,	,	,
cord-285262-690kpupt	493	44	2017	2017	CD
cord-285262-690kpupt	493	45	)	)	-RRB-
cord-285262-690kpupt	493	46	.	.	.
cord-285262-690kpupt	494	1	Alternatively	alternatively	RB
cord-285262-690kpupt	494	2	,	,	,
cord-285262-690kpupt	494	3	disruption	disruption	NN
cord-285262-690kpupt	494	4	of	of	IN
cord-285262-690kpupt	494	5	the	the	DT
cord-285262-690kpupt	494	6	glycolysis	glycolysis	NN
cord-285262-690kpupt	494	7	,	,	,
cord-285262-690kpupt	494	8	leading	lead	VBG
cord-285262-690kpupt	494	9	to	to	IN
cord-285262-690kpupt	494	10	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	494	11	ROS	ROS	NNP
cord-285262-690kpupt	494	12	production	production	NN
cord-285262-690kpupt	494	13	is	be	VBZ
cord-285262-690kpupt	494	14	also	also	RB
cord-285262-690kpupt	494	15	proposed	propose	VBN
cord-285262-690kpupt	494	16	as	as	IN
cord-285262-690kpupt	494	17	the	the	DT
cord-285262-690kpupt	494	18	intracellular	intracellular	JJ
cord-285262-690kpupt	494	19	mechanism	mechanism	NN
cord-285262-690kpupt	494	20	of	of	IN
cord-285262-690kpupt	494	21	the	the	DT
cord-285262-690kpupt	494	22	NLRP3	nlrp3	NN
cord-285262-690kpupt	494	23	activation	activation	NN
cord-285262-690kpupt	494	24	(	(	-LRB-
cord-285262-690kpupt	494	25	Sanman	Sanman	NNP
cord-285262-690kpupt	494	26	et	et	FW
cord-285262-690kpupt	494	27	al	al	NNP
cord-285262-690kpupt	494	28	.	.	NNP
cord-285262-690kpupt	494	29	,	,	,
cord-285262-690kpupt	494	30	2016	2016	CD
cord-285262-690kpupt	494	31	)	)	-RRB-
cord-285262-690kpupt	494	32	.	.	.
cord-285262-690kpupt	495	1	Besides	besides	RB
cord-285262-690kpupt	495	2	,	,	,
cord-285262-690kpupt	495	3	a	a	DT
cord-285262-690kpupt	495	4	TLR	TLR	NNP
cord-285262-690kpupt	495	5	triggered	trigger	VBD
cord-285262-690kpupt	495	6	second	second	JJ
cord-285262-690kpupt	495	7	priming	prime	VBG
cord-285262-690kpupt	495	8	event	event	NN
cord-285262-690kpupt	495	9	by	by	IN
cord-285262-690kpupt	495	10	ubiquitination	ubiquitination	NN
cord-285262-690kpupt	495	11	is	be	VBZ
cord-285262-690kpupt	495	12	necessary	necessary	JJ
cord-285262-690kpupt	495	13	to	to	TO
cord-285262-690kpupt	495	14	stimulate	stimulate	VB
cord-285262-690kpupt	495	15	the	the	DT
cord-285262-690kpupt	495	16	NLRP3	NLRP3	NNP
cord-285262-690kpupt	495	17	inflammasome	inflammasome	NNP
cord-285262-690kpupt	495	18	in	in	IN
cord-285262-690kpupt	495	19	mice	mice	NN
cord-285262-690kpupt	495	20	myeloid	myeloid	NN
cord-285262-690kpupt	495	21	cells	cell	NNS
cord-285262-690kpupt	495	22	(	(	-LRB-
cord-285262-690kpupt	495	23	Humphries	Humphries	NNP
cord-285262-690kpupt	495	24	et	et	NNP
cord-285262-690kpupt	495	25	al	al	NNP
cord-285262-690kpupt	495	26	.	.	NNP
cord-285262-690kpupt	495	27	,	,	,
cord-285262-690kpupt	495	28	2018	2018	CD
cord-285262-690kpupt	495	29	)	)	-RRB-
cord-285262-690kpupt	495	30	.	.	.
cord-285262-690kpupt	496	1	Anthrax	anthrax	NN
cord-285262-690kpupt	496	2	lethal	lethal	JJ
cord-285262-690kpupt	496	3	toxin	toxin	NN
cord-285262-690kpupt	496	4	(	(	-LRB-
cord-285262-690kpupt	496	5	LT	LT	NNP
cord-285262-690kpupt	496	6	)	)	-RRB-
cord-285262-690kpupt	496	7	,	,	,
cord-285262-690kpupt	496	8	the	the	DT
cord-285262-690kpupt	496	9	critical	critical	JJ
cord-285262-690kpupt	496	10	virulence	virulence	NN
cord-285262-690kpupt	496	11	factor	factor	NN
cord-285262-690kpupt	496	12	of	of	IN
cord-285262-690kpupt	496	13	the	the	DT
cord-285262-690kpupt	496	14	Bacillus	Bacillus	NNP
cord-285262-690kpupt	496	15	anthracis	anthracis	NN
cord-285262-690kpupt	496	16	induces	induce	VBZ
cord-285262-690kpupt	496	17	caspase-1	caspase-1	NNP
cord-285262-690kpupt	496	18	activation	activation	NN
cord-285262-690kpupt	496	19	and	and	CC
cord-285262-690kpupt	496	20	lytic	lytic	JJ
cord-285262-690kpupt	496	21	cell	cell	NN
cord-285262-690kpupt	496	22	death	death	NN
cord-285262-690kpupt	496	23	through	through	IN
cord-285262-690kpupt	496	24	the	the	DT
cord-285262-690kpupt	496	25	cytosolic	cytosolic	JJ
cord-285262-690kpupt	496	26	NLR	NLR	NNP
cord-285262-690kpupt	496	27	family	family	NN
cord-285262-690kpupt	496	28	member	member	NN
cord-285262-690kpupt	496	29	NLRP1B	nlrp1b	NN
cord-285262-690kpupt	496	30	in	in	IN
cord-285262-690kpupt	496	31	macrophages	macrophage	NNS
cord-285262-690kpupt	496	32	(	(	-LRB-
cord-285262-690kpupt	496	33	Boyden	Boyden	NNP
cord-285262-690kpupt	496	34	and	and	CC
cord-285262-690kpupt	496	35	Dietrich	Dietrich	NNP
cord-285262-690kpupt	496	36	,	,	,
cord-285262-690kpupt	496	37	2006	2006	CD
cord-285262-690kpupt	496	38	)	)	-RRB-
cord-285262-690kpupt	496	39	and	and	CC
cord-285262-690kpupt	496	40	dendritic	dendritic	JJ
cord-285262-690kpupt	496	41	cells	cell	NNS
cord-285262-690kpupt	496	42	(	(	-LRB-
cord-285262-690kpupt	497	1	Fink	Fink	NNP
cord-285262-690kpupt	497	2	et	et	FW
cord-285262-690kpupt	497	3	al	al	NNP
cord-285262-690kpupt	497	4	.	.	NNP
cord-285262-690kpupt	497	5	,	,	,
cord-285262-690kpupt	497	6	2008	2008	CD
cord-285262-690kpupt	497	7	)	)	-RRB-
cord-285262-690kpupt	498	1	(	(	-LRB-
cord-285262-690kpupt	498	2	Fig	Fig	NNP
cord-285262-690kpupt	498	3	.	.	.
cord-285262-690kpupt	498	4	3	3	CD
cord-285262-690kpupt	498	5	)	)	-RRB-
cord-285262-690kpupt	498	6	.	.	.
cord-285262-690kpupt	499	1	In	in	IN
cord-285262-690kpupt	499	2	humans	human	NNS
cord-285262-690kpupt	499	3	,	,	,
cord-285262-690kpupt	499	4	NLRP1B	NLRP1B	NNP
cord-285262-690kpupt	499	5	possess	possess	VBP
cord-285262-690kpupt	499	6	a	a	DT
cord-285262-690kpupt	499	7	pyrin	pyrin	NN
cord-285262-690kpupt	499	8	domain	domain	NN
cord-285262-690kpupt	499	9	and	and	CC
cord-285262-690kpupt	499	10	lacks	lack	VBZ
cord-285262-690kpupt	499	11	the	the	DT
cord-285262-690kpupt	499	12	CARD	card	NN
cord-285262-690kpupt	499	13	domain	domain	NN
cord-285262-690kpupt	499	14	,	,	,
cord-285262-690kpupt	499	15	therefore	therefore	RB
cord-285262-690kpupt	499	16	ASC	ASC	NNP
cord-285262-690kpupt	499	17	is	be	VBZ
cord-285262-690kpupt	499	18	required	require	VBN
cord-285262-690kpupt	499	19	as	as	IN
cord-285262-690kpupt	499	20	an	an	DT
cord-285262-690kpupt	499	21	adaptor	adaptor	NN
cord-285262-690kpupt	499	22	protein	protein	NN
cord-285262-690kpupt	499	23	to	to	TO
cord-285262-690kpupt	499	24	activate	activate	VB
cord-285262-690kpupt	499	25	caspase-1	caspase-1	NNP
cord-285262-690kpupt	499	26	.	.	.
cord-285262-690kpupt	500	1	It	-PRON-	PRP
cord-285262-690kpupt	500	2	has	have	VBZ
cord-285262-690kpupt	500	3	been	be	VBN
cord-285262-690kpupt	500	4	demonstrated	demonstrate	VBN
cord-285262-690kpupt	500	5	that	that	IN
cord-285262-690kpupt	500	6	LT	LT	NNP
cord-285262-690kpupt	500	7	was	be	VBD
cord-285262-690kpupt	500	8	transported	transport	VBN
cord-285262-690kpupt	500	9	to	to	IN
cord-285262-690kpupt	500	10	the	the	DT
cord-285262-690kpupt	500	11	cytosol	cytosol	NN
cord-285262-690kpupt	500	12	,	,	,
cord-285262-690kpupt	500	13	where	where	WRB
cord-285262-690kpupt	500	14	it	-PRON-	PRP
cord-285262-690kpupt	500	15	could	could	MD
cord-285262-690kpupt	500	16	interact	interact	VB
cord-285262-690kpupt	500	17	with	with	IN
cord-285262-690kpupt	500	18	additional	additional	JJ
cord-285262-690kpupt	500	19	factors	factor	NNS
cord-285262-690kpupt	500	20	,	,	,
cord-285262-690kpupt	500	21	however	however	RB
cord-285262-690kpupt	500	22	the	the	DT
cord-285262-690kpupt	500	23	question	question	NN
cord-285262-690kpupt	500	24	whether	whether	IN
cord-285262-690kpupt	500	25	NLRP1B	NLRP1B	NNP
cord-285262-690kpupt	500	26	directly	directly	RB
cord-285262-690kpupt	500	27	interacted	interact	VBD
cord-285262-690kpupt	500	28	the	the	DT
cord-285262-690kpupt	500	29	LT	LT	NNP
cord-285262-690kpupt	500	30	remained	remain	VBD
cord-285262-690kpupt	500	31	elusive	elusive	JJ
cord-285262-690kpupt	500	32	.	.	.
cord-285262-690kpupt	501	1	This	this	DT
cord-285262-690kpupt	501	2	question	question	NN
cord-285262-690kpupt	501	3	was	be	VBD
cord-285262-690kpupt	501	4	answered	answer	VBN
cord-285262-690kpupt	501	5	few	few	JJ
cord-285262-690kpupt	501	6	years	year	NNS
cord-285262-690kpupt	501	7	later	later	RB
cord-285262-690kpupt	501	8	in	in	IN
cord-285262-690kpupt	501	9	a	a	DT
cord-285262-690kpupt	501	10	study	study	NN
cord-285262-690kpupt	501	11	where	where	WRB
cord-285262-690kpupt	501	12	the	the	DT
cord-285262-690kpupt	501	13	direct	direct	JJ
cord-285262-690kpupt	501	14	proteolytic	proteolytic	JJ
cord-285262-690kpupt	501	15	cleavage	cleavage	NN
cord-285262-690kpupt	501	16	of	of	IN
cord-285262-690kpupt	501	17	NLRP1B	nlrp1b	NN
cord-285262-690kpupt	501	18	could	could	MD
cord-285262-690kpupt	501	19	activate	activate	VB
cord-285262-690kpupt	501	20	NLRP1B	NLRP1B	NNP
cord-285262-690kpupt	501	21	driven	drive	VBN
cord-285262-690kpupt	501	22	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	501	23	in	in	IN
cord-285262-690kpupt	501	24	mice	mouse	NNS
cord-285262-690kpupt	501	25	and	and	CC
cord-285262-690kpupt	501	26	rat	rat	NN
cord-285262-690kpupt	501	27	cells	cell	NNS
cord-285262-690kpupt	502	1	(	(	-LRB-
cord-285262-690kpupt	502	2	Chavarría	Chavarría	NNP
cord-285262-690kpupt	502	3	-	-	HYPH
cord-285262-690kpupt	502	4	Smith	Smith	NNP
cord-285262-690kpupt	502	5	and	and	CC
cord-285262-690kpupt	502	6	Vance	Vance	NNP
cord-285262-690kpupt	502	7	,	,	,
cord-285262-690kpupt	502	8	2013	2013	CD
cord-285262-690kpupt	502	9	)	)	-RRB-
cord-285262-690kpupt	502	10	.	.	.
cord-285262-690kpupt	503	1	The	the	DT
cord-285262-690kpupt	503	2	role	role	NN
cord-285262-690kpupt	503	3	of	of	IN
cord-285262-690kpupt	503	4	caspase-11	caspase-11	NNP
cord-285262-690kpupt	503	5	and	and	CC
cord-285262-690kpupt	503	6	caspase-4/-5	caspase-4/-5	NN
cord-285262-690kpupt	504	1	The	the	DT
cord-285262-690kpupt	504	2	mouse	mouse	NN
cord-285262-690kpupt	504	3	caspase-11	caspase-11	XX
cord-285262-690kpupt	504	4	and	and	CC
cord-285262-690kpupt	504	5	its	-PRON-	PRP$
cord-285262-690kpupt	504	6	duplicated	duplicate	VBN
cord-285262-690kpupt	504	7	human	human	JJ
cord-285262-690kpupt	504	8	homologs	homolog	NNS
cord-285262-690kpupt	504	9	caspase-4	caspase-4	NNP
cord-285262-690kpupt	505	1	and	and	CC
cord-285262-690kpupt	505	2	-5	-5	NNP
cord-285262-690kpupt	505	3	are	be	VBP
cord-285262-690kpupt	505	4	often	often	RB
cord-285262-690kpupt	505	5	referred	refer	VBN
cord-285262-690kpupt	505	6	as	as	IN
cord-285262-690kpupt	505	7	non	non	JJ
cord-285262-690kpupt	505	8	-	-	JJ
cord-285262-690kpupt	505	9	canonical	canonical	JJ
cord-285262-690kpupt	505	10	inflammasome	inflammasome	NN
cord-285262-690kpupt	505	11	,	,	,
cord-285262-690kpupt	505	12	since	since	IN
cord-285262-690kpupt	505	13	they	-PRON-	PRP
cord-285262-690kpupt	505	14	function	function	VBP
cord-285262-690kpupt	505	15	as	as	IN
cord-285262-690kpupt	505	16	direct	direct	JJ
cord-285262-690kpupt	505	17	LPS	LPS	NNP
cord-285262-690kpupt	505	18	sensors	sensor	NNS
cord-285262-690kpupt	505	19	in	in	IN
cord-285262-690kpupt	505	20	the	the	DT
cord-285262-690kpupt	505	21	cytosol	cytosol	NN
cord-285262-690kpupt	506	1	(	(	-LRB-
cord-285262-690kpupt	506	2	Fig	Fig	NNP
cord-285262-690kpupt	506	3	.	.	.
cord-285262-690kpupt	506	4	3	3	CD
cord-285262-690kpupt	506	5	)	)	-RRB-
cord-285262-690kpupt	506	6	.	.	.
cord-285262-690kpupt	507	1	The	the	DT
cord-285262-690kpupt	507	2	CARD	card	NN
cord-285262-690kpupt	507	3	domain	domain	NN
cord-285262-690kpupt	507	4	of	of	IN
cord-285262-690kpupt	507	5	the	the	DT
cord-285262-690kpupt	507	6	caspase-4	caspase-4	NNP
cord-285262-690kpupt	507	7	is	be	VBZ
cord-285262-690kpupt	507	8	capable	capable	JJ
cord-285262-690kpupt	507	9	to	to	TO
cord-285262-690kpupt	507	10	bind	bind	VB
cord-285262-690kpupt	507	11	LPS	LPS	NNP
cord-285262-690kpupt	507	12	molecules	molecule	NNS
cord-285262-690kpupt	507	13	and	and	CC
cord-285262-690kpupt	507	14	,	,	,
cord-285262-690kpupt	507	15	surprisingly	surprisingly	RB
cord-285262-690kpupt	507	16	,	,	,
cord-285262-690kpupt	507	17	can	can	MD
cord-285262-690kpupt	507	18	directly	directly	RB
cord-285262-690kpupt	507	19	cleave	cleave	VB
cord-285262-690kpupt	507	20	LPS	LPS	NNP
cord-285262-690kpupt	507	21	micelles	micelle	NNS
cord-285262-690kpupt	507	22	.	.	.
cord-285262-690kpupt	508	1	The	the	DT
cord-285262-690kpupt	508	2	advantage	advantage	NN
cord-285262-690kpupt	508	3	of	of	IN
cord-285262-690kpupt	508	4	the	the	DT
cord-285262-690kpupt	508	5	caspase-11	caspase-11	NNS
cord-285262-690kpupt	508	6	and	and	CC
cord-285262-690kpupt	508	7	caspase-4/5	caspase-4/5	NN
cord-285262-690kpupt	508	8	inflammasome	inflammasome	NN
cord-285262-690kpupt	508	9	can	can	MD
cord-285262-690kpupt	508	10	be	be	VB
cord-285262-690kpupt	508	11	understood	understand	VBN
cord-285262-690kpupt	508	12	in	in	IN
cord-285262-690kpupt	508	13	situations	situation	NNS
cord-285262-690kpupt	508	14	in	in	IN
cord-285262-690kpupt	508	15	which	which	WDT
cord-285262-690kpupt	508	16	the	the	DT
cord-285262-690kpupt	508	17	pathogen	pathogen	NN
cord-285262-690kpupt	508	18	attempts	attempt	VBZ
cord-285262-690kpupt	508	19	to	to	TO
cord-285262-690kpupt	508	20	evade	evade	VB
cord-285262-690kpupt	508	21	caspase-1	caspase-1	NNP
cord-285262-690kpupt	508	22	activation	activation	NN
cord-285262-690kpupt	508	23	,	,	,
cord-285262-690kpupt	508	24	for	for	IN
cord-285262-690kpupt	508	25	instance	instance	NN
cord-285262-690kpupt	508	26	by	by	IN
cord-285262-690kpupt	508	27	blocking	block	VBG
cord-285262-690kpupt	508	28	the	the	DT
cord-285262-690kpupt	508	29	NLRC-4	NLRC-4	NNP
cord-285262-690kpupt	508	30	inflammasome	inflammasome	NN
cord-285262-690kpupt	508	31	activation	activation	NN
cord-285262-690kpupt	508	32	.	.	.
cord-285262-690kpupt	509	1	It	-PRON-	PRP
cord-285262-690kpupt	509	2	has	have	VBZ
cord-285262-690kpupt	509	3	been	be	VBN
cord-285262-690kpupt	509	4	recently	recently	RB
cord-285262-690kpupt	509	5	shown	show	VBN
cord-285262-690kpupt	509	6	that	that	IN
cord-285262-690kpupt	509	7	the	the	DT
cord-285262-690kpupt	509	8	Shiga	Shiga	NNP
cord-285262-690kpupt	509	9	toxin	toxin	NN
cord-285262-690kpupt	509	10	from	from	IN
cord-285262-690kpupt	509	11	the	the	DT
cord-285262-690kpupt	509	12	pathogenic	pathogenic	JJ
cord-285262-690kpupt	509	13	enterohemorrhagic	enterohemorrhagic	JJ
cord-285262-690kpupt	509	14	Escherichia	Escherichia	NNP
cord-285262-690kpupt	509	15	coli	coli	NNS
cord-285262-690kpupt	509	16	could	could	MD
cord-285262-690kpupt	509	17	lead	lead	VB
cord-285262-690kpupt	509	18	to	to	IN
cord-285262-690kpupt	509	19	the	the	DT
cord-285262-690kpupt	509	20	activation	activation	NN
cord-285262-690kpupt	509	21	of	of	IN
cord-285262-690kpupt	509	22	caspase-4	caspase-4	NNP
cord-285262-690kpupt	509	23	and	and	CC
cord-285262-690kpupt	509	24	result	result	VB
cord-285262-690kpupt	509	25	in	in	IN
cord-285262-690kpupt	509	26	the	the	DT
cord-285262-690kpupt	509	27	cleavage	cleavage	NN
cord-285262-690kpupt	509	28	of	of	IN
cord-285262-690kpupt	509	29	GSDMD	GSDMD	NNP
cord-285262-690kpupt	509	30	upstream	upstream	RB
cord-285262-690kpupt	509	31	of	of	IN
cord-285262-690kpupt	509	32	the	the	DT
cord-285262-690kpupt	509	33	NLRP3	nlrp3	NN
cord-285262-690kpupt	509	34	activation	activation	NN
cord-285262-690kpupt	509	35	in	in	IN
cord-285262-690kpupt	509	36	human	human	JJ
cord-285262-690kpupt	509	37	THP-1	THP-1	NNP
cord-285262-690kpupt	509	38	cells	cell	NNS
cord-285262-690kpupt	509	39	(	(	-LRB-
cord-285262-690kpupt	509	40	Platnich	Platnich	NNP
cord-285262-690kpupt	509	41	et	et	NNP
cord-285262-690kpupt	509	42	al	al	NNP
cord-285262-690kpupt	509	43	.	.	NNP
cord-285262-690kpupt	509	44	,	,	,
cord-285262-690kpupt	509	45	2018	2018	CD
cord-285262-690kpupt	509	46	)	)	-RRB-
cord-285262-690kpupt	509	47	.	.	.
cord-285262-690kpupt	510	1	Furthermore	furthermore	RB
cord-285262-690kpupt	510	2	,	,	,
cord-285262-690kpupt	510	3	the	the	DT
cord-285262-690kpupt	510	4	Gram	gram	NN
cord-285262-690kpupt	510	5	-	-	HYPH
cord-285262-690kpupt	510	6	negative	negative	JJ
cord-285262-690kpupt	510	7	Burkholderia	Burkholderia	NNP
cord-285262-690kpupt	510	8	thailandensis	thailandensis	NN
cord-285262-690kpupt	510	9	infection	infection	NN
cord-285262-690kpupt	510	10	triggers	trigger	VBZ
cord-285262-690kpupt	510	11	the	the	DT
cord-285262-690kpupt	510	12	activation	activation	NN
cord-285262-690kpupt	510	13	of	of	IN
cord-285262-690kpupt	510	14	caspase-11	caspase-11	NNP
cord-285262-690kpupt	510	15	in	in	IN
cord-285262-690kpupt	510	16	mice	mouse	NNS
cord-285262-690kpupt	511	1	(	(	-LRB-
cord-285262-690kpupt	511	2	Aachoui	Aachoui	NNP
cord-285262-690kpupt	511	3	et	et	FW
cord-285262-690kpupt	511	4	al	al	NNP
cord-285262-690kpupt	511	5	.	.	NNP
cord-285262-690kpupt	511	6	,	,	,
cord-285262-690kpupt	511	7	2013	2013	CD
cord-285262-690kpupt	511	8	)	)	-RRB-
cord-285262-690kpupt	511	9	and	and	CC
cord-285262-690kpupt	511	10	Legionella	Legionella	NNP
cord-285262-690kpupt	511	11	(	(	-LRB-
cord-285262-690kpupt	511	12	L.	L.	NNP
cord-285262-690kpupt	511	13	)	)	-RRB-
cord-285262-690kpupt	511	14	pneumophila	pneumophila	NN
cord-285262-690kpupt	511	15	similarly	similarly	RB
cord-285262-690kpupt	511	16	elicits	elicit	VBZ
cord-285262-690kpupt	511	17	the	the	DT
cord-285262-690kpupt	511	18	activation	activation	NN
cord-285262-690kpupt	511	19	of	of	IN
cord-285262-690kpupt	511	20	caspase-11	caspase-11	NNP
cord-285262-690kpupt	511	21	,	,	,
cord-285262-690kpupt	511	22	which	which	WDT
cord-285262-690kpupt	511	23	in	in	IN
cord-285262-690kpupt	511	24	this	this	DT
cord-285262-690kpupt	511	25	scenario	scenario	NN
cord-285262-690kpupt	511	26	is	be	VBZ
cord-285262-690kpupt	511	27	dependent	dependent	JJ
cord-285262-690kpupt	511	28	on	on	IN
cord-285262-690kpupt	511	29	the	the	DT
cord-285262-690kpupt	511	30	IFN	IFN	NNP
cord-285262-690kpupt	511	31	signaling	signaling	NN
cord-285262-690kpupt	511	32	.	.	.
cord-285262-690kpupt	512	1	Interestingly	interestingly	RB
cord-285262-690kpupt	512	2	,	,	,
cord-285262-690kpupt	512	3	loss	loss	NN
cord-285262-690kpupt	512	4	of	of	IN
cord-285262-690kpupt	512	5	IFNs	ifn	NNS
cord-285262-690kpupt	512	6	does	do	VBZ
cord-285262-690kpupt	512	7	not	not	RB
cord-285262-690kpupt	512	8	lead	lead	VB
cord-285262-690kpupt	512	9	to	to	IN
cord-285262-690kpupt	512	10	the	the	DT
cord-285262-690kpupt	512	11	inhibition	inhibition	NN
cord-285262-690kpupt	512	12	of	of	IN
cord-285262-690kpupt	512	13	caspase-11	caspase-11	CD
cord-285262-690kpupt	512	14	expression	expression	NN
cord-285262-690kpupt	512	15	,	,	,
cord-285262-690kpupt	512	16	but	but	CC
cord-285262-690kpupt	512	17	it	-PRON-	PRP
cord-285262-690kpupt	512	18	hampers	hamper	VBZ
cord-285262-690kpupt	512	19	the	the	DT
cord-285262-690kpupt	512	20	caspase-11	caspase-11	CD
cord-285262-690kpupt	512	21	dependent	dependent	JJ
cord-285262-690kpupt	512	22	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	512	23	in	in	IN
cord-285262-690kpupt	512	24	macrophages	macrophage	NNS
cord-285262-690kpupt	512	25	(	(	-LRB-
cord-285262-690kpupt	512	26	Case	case	NN
cord-285262-690kpupt	512	27	et	et	FW
cord-285262-690kpupt	512	28	al	al	NNP
cord-285262-690kpupt	512	29	.	.	NNP
cord-285262-690kpupt	512	30	,	,	,
cord-285262-690kpupt	512	31	2013	2013	CD
cord-285262-690kpupt	512	32	)	)	-RRB-
cord-285262-690kpupt	512	33	.	.	.
cord-285262-690kpupt	513	1	The	the	DT
cord-285262-690kpupt	513	2	requirement	requirement	NN
cord-285262-690kpupt	513	3	of	of	IN
cord-285262-690kpupt	513	4	IFNs	ifn	NNS
cord-285262-690kpupt	513	5	leads	lead	VBZ
cord-285262-690kpupt	513	6	us	-PRON-	PRP
cord-285262-690kpupt	513	7	to	to	IN
cord-285262-690kpupt	513	8	the	the	DT
cord-285262-690kpupt	513	9	problem	problem	NN
cord-285262-690kpupt	513	10	of	of	IN
cord-285262-690kpupt	513	11	the	the	DT
cord-285262-690kpupt	513	12	cytosolic	cytosolic	JJ
cord-285262-690kpupt	513	13	LPS	LPS	NNP
cord-285262-690kpupt	513	14	detection	detection	NN
cord-285262-690kpupt	513	15	.	.	.
cord-285262-690kpupt	514	1	The	the	DT
cord-285262-690kpupt	514	2	Gram	gram	NN
cord-285262-690kpupt	514	3	-	-	HYPH
cord-285262-690kpupt	514	4	negative	negative	JJ
cord-285262-690kpupt	514	5	bacteria	bacteria	NNS
cord-285262-690kpupt	514	6	Salmonella	Salmonella	NNP
cord-285262-690kpupt	514	7	typhimurium	typhimurium	NNP
cord-285262-690kpupt	514	8	and	and	CC
cord-285262-690kpupt	514	9	L.	L.	NNP
cord-285262-690kpupt	514	10	pneumophila	pneumophila	NN
cord-285262-690kpupt	514	11	are	be	VBP
cord-285262-690kpupt	514	12	normally	normally	RB
cord-285262-690kpupt	514	13	located	locate	VBN
cord-285262-690kpupt	514	14	in	in	IN
cord-285262-690kpupt	514	15	vacuoles	vacuole	NNS
cord-285262-690kpupt	514	16	,	,	,
cord-285262-690kpupt	514	17	hence	hence	RB
cord-285262-690kpupt	514	18	they	-PRON-	PRP
cord-285262-690kpupt	514	19	are	be	VBP
cord-285262-690kpupt	514	20	protected	protect	VBN
cord-285262-690kpupt	514	21	from	from	IN
cord-285262-690kpupt	514	22	cytoplasmic	cytoplasmic	JJ
cord-285262-690kpupt	514	23	pathogen	pathogen	NN
cord-285262-690kpupt	514	24	sensors	sensor	NNS
cord-285262-690kpupt	514	25	as	as	IN
cord-285262-690kpupt	514	26	for	for	IN
cord-285262-690kpupt	514	27	instance	instance	NN
cord-285262-690kpupt	514	28	caspase-11	caspase-11	CD
cord-285262-690kpupt	514	29	.	.	.
cord-285262-690kpupt	515	1	The	the	DT
cord-285262-690kpupt	515	2	guanylate	guanylate	NN
cord-285262-690kpupt	515	3	-	-	HYPH
cord-285262-690kpupt	515	4	binding	bind	VBG
cord-285262-690kpupt	515	5	proteins	protein	NNS
cord-285262-690kpupt	515	6	(	(	-LRB-
cord-285262-690kpupt	515	7	GBPs	gbps	$
cord-285262-690kpupt	515	8	)	)	-RRB-
cord-285262-690kpupt	515	9	represent	represent	VB
cord-285262-690kpupt	515	10	a	a	DT
cord-285262-690kpupt	515	11	family	family	NN
cord-285262-690kpupt	515	12	of	of	IN
cord-285262-690kpupt	515	13	IFN	IFN	NNP
cord-285262-690kpupt	515	14	-	-	HYPH
cord-285262-690kpupt	515	15	inducible	inducible	JJ
cord-285262-690kpupt	515	16	GTPases	gtpase	NNS
cord-285262-690kpupt	515	17	.	.	.
cord-285262-690kpupt	516	1	It	-PRON-	PRP
cord-285262-690kpupt	516	2	has	have	VBZ
cord-285262-690kpupt	516	3	been	be	VBN
cord-285262-690kpupt	516	4	demonstrated	demonstrate	VBN
cord-285262-690kpupt	516	5	that	that	IN
cord-285262-690kpupt	516	6	IFN	IFN	NNP
cord-285262-690kpupt	516	7	-	-	HYPH
cord-285262-690kpupt	516	8	stimulated	stimulate	VBN
cord-285262-690kpupt	516	9	GBP	GBP	NNP
cord-285262-690kpupt	516	10	members	member	NNS
cord-285262-690kpupt	516	11	were	be	VBD
cord-285262-690kpupt	516	12	capable	capable	JJ
cord-285262-690kpupt	516	13	to	to	TO
cord-285262-690kpupt	516	14	bind	bind	VB
cord-285262-690kpupt	516	15	the	the	DT
cord-285262-690kpupt	516	16	vacuoles	vacuole	NNS
cord-285262-690kpupt	516	17	and	and	CC
cord-285262-690kpupt	516	18	initiate	initiate	VB
cord-285262-690kpupt	516	19	the	the	DT
cord-285262-690kpupt	516	20	rupture	rupture	NN
cord-285262-690kpupt	516	21	of	of	IN
cord-285262-690kpupt	516	22	the	the	DT
cord-285262-690kpupt	516	23	membrane	membrane	NN
cord-285262-690kpupt	516	24	,	,	,
cord-285262-690kpupt	516	25	which	which	WDT
cord-285262-690kpupt	516	26	in	in	IN
cord-285262-690kpupt	516	27	turn	turn	NN
cord-285262-690kpupt	516	28	resulted	result	VBD
cord-285262-690kpupt	516	29	in	in	IN
cord-285262-690kpupt	516	30	the	the	DT
cord-285262-690kpupt	516	31	release	release	NN
cord-285262-690kpupt	516	32	of	of	IN
cord-285262-690kpupt	516	33	the	the	DT
cord-285262-690kpupt	516	34	bacterial	bacterial	JJ
cord-285262-690kpupt	516	35	LPS	lp	NNS
cord-285262-690kpupt	516	36	,	,	,
cord-285262-690kpupt	516	37	exposing	expose	VBG
cord-285262-690kpupt	516	38	it	-PRON-	PRP
cord-285262-690kpupt	516	39	to	to	IN
cord-285262-690kpupt	516	40	the	the	DT
cord-285262-690kpupt	516	41	cytoplasmic	cytoplasmic	JJ
cord-285262-690kpupt	516	42	caspase-11	caspase-11	NNS
cord-285262-690kpupt	516	43	(	(	-LRB-
cord-285262-690kpupt	516	44	Meunier	Meunier	NNP
cord-285262-690kpupt	516	45	et	et	NNP
cord-285262-690kpupt	516	46	al	al	NNP
cord-285262-690kpupt	516	47	.	.	NNP
cord-285262-690kpupt	516	48	,	,	,
cord-285262-690kpupt	516	49	2014	2014	CD
cord-285262-690kpupt	516	50	;	;	:
cord-285262-690kpupt	516	51	Rupper	Rupper	NNP
cord-285262-690kpupt	516	52	and	and	CC
cord-285262-690kpupt	516	53	Cardelli	Cardelli	NNP
cord-285262-690kpupt	516	54	,	,	,
cord-285262-690kpupt	516	55	2008	2008	CD
cord-285262-690kpupt	516	56	)	)	-RRB-
cord-285262-690kpupt	516	57	.	.	.
cord-285262-690kpupt	517	1	Conversely	conversely	RB
cord-285262-690kpupt	517	2	,	,	,
cord-285262-690kpupt	517	3	IFNs	IFNs	NNP
cord-285262-690kpupt	517	4	can	can	MD
cord-285262-690kpupt	517	5	also	also	RB
cord-285262-690kpupt	517	6	directly	directly	RB
cord-285262-690kpupt	517	7	regulate	regulate	VB
cord-285262-690kpupt	517	8	the	the	DT
cord-285262-690kpupt	517	9	transcription	transcription	NN
cord-285262-690kpupt	517	10	of	of	IN
cord-285262-690kpupt	517	11	the	the	DT
cord-285262-690kpupt	517	12	pro	pro	JJ
cord-285262-690kpupt	517	13	-	-	JJ
cord-285262-690kpupt	517	14	inflammatory	inflammatory	JJ
cord-285262-690kpupt	517	15	caspases	caspase	NNS
cord-285262-690kpupt	517	16	.	.	.
cord-285262-690kpupt	518	1	Based	base	VBN
cord-285262-690kpupt	518	2	on	on	IN
cord-285262-690kpupt	518	3	a	a	DT
cord-285262-690kpupt	518	4	new	new	JJ
cord-285262-690kpupt	518	5	genome	genome	NN
cord-285262-690kpupt	518	6	-	-	HYPH
cord-285262-690kpupt	518	7	wide	wide	JJ
cord-285262-690kpupt	518	8	screen	screen	NN
cord-285262-690kpupt	518	9	,	,	,
cord-285262-690kpupt	518	10	the	the	DT
cord-285262-690kpupt	518	11	interferon	interferon	NN
cord-285262-690kpupt	518	12	regulatory	regulatory	JJ
cord-285262-690kpupt	518	13	factor	factor	NN
cord-285262-690kpupt	518	14	2	2	CD
cord-285262-690kpupt	519	1	(	(	-LRB-
cord-285262-690kpupt	519	2	IRF2	IRF2	NNP
cord-285262-690kpupt	519	3	)	)	-RRB-
cord-285262-690kpupt	519	4	seems	seem	VBZ
cord-285262-690kpupt	519	5	to	to	TO
cord-285262-690kpupt	519	6	act	act	VB
cord-285262-690kpupt	519	7	as	as	IN
cord-285262-690kpupt	519	8	the	the	DT
cord-285262-690kpupt	519	9	main	main	JJ
cord-285262-690kpupt	519	10	transcription	transcription	NN
cord-285262-690kpupt	519	11	factor	factor	NN
cord-285262-690kpupt	519	12	directly	directly	RB
cord-285262-690kpupt	519	13	regulating	regulate	VBG
cord-285262-690kpupt	519	14	caspase-4	caspase-4	NNP
cord-285262-690kpupt	519	15	expression	expression	NN
cord-285262-690kpupt	519	16	upon	upon	IN
cord-285262-690kpupt	519	17	LPS	LPS	NNP
cord-285262-690kpupt	519	18	stimulus	stimulus	NN
cord-285262-690kpupt	519	19	in	in	IN
cord-285262-690kpupt	519	20	human	human	JJ
cord-285262-690kpupt	519	21	monocytes	monocyte	NNS
cord-285262-690kpupt	519	22	(	(	-LRB-
cord-285262-690kpupt	519	23	Benaoudia	Benaoudia	NNP
cord-285262-690kpupt	519	24	et	et	NNP
cord-285262-690kpupt	519	25	al	al	NNP
cord-285262-690kpupt	519	26	.	.	NNP
cord-285262-690kpupt	519	27	,	,	,
cord-285262-690kpupt	519	28	2019	2019	CD
cord-285262-690kpupt	519	29	)	)	-RRB-
cord-285262-690kpupt	519	30	.	.	.
cord-285262-690kpupt	520	1	The	the	DT
cord-285262-690kpupt	520	2	role	role	NN
cord-285262-690kpupt	520	3	of	of	IN
cord-285262-690kpupt	520	4	the	the	DT
cord-285262-690kpupt	520	5	AIM2	AIM2	NNP
cord-285262-690kpupt	520	6	inflammasome	inflammasome	NN
cord-285262-690kpupt	520	7	in	in	IN
cord-285262-690kpupt	520	8	the	the	DT
cord-285262-690kpupt	520	9	recognition	recognition	NN
cord-285262-690kpupt	520	10	of	of	IN
cord-285262-690kpupt	520	11	the	the	DT
cord-285262-690kpupt	520	12	intracellular	intracellular	JJ
cord-285262-690kpupt	520	13	bacteria	bacteria	NNS
cord-285262-690kpupt	520	14	has	have	VBZ
cord-285262-690kpupt	520	15	been	be	VBN
cord-285262-690kpupt	520	16	demonstrated	demonstrate	VBN
cord-285262-690kpupt	520	17	in	in	IN
cord-285262-690kpupt	520	18	response	response	NN
cord-285262-690kpupt	520	19	to	to	IN
cord-285262-690kpupt	520	20	Listeria	Listeria	NNP
cord-285262-690kpupt	520	21	monocytogenes	monocytogenes	NNP
cord-285262-690kpupt	520	22	,	,	,
cord-285262-690kpupt	520	23	Francisella	Francisella	NNP
cord-285262-690kpupt	520	24	(	(	-LRB-
cord-285262-690kpupt	520	25	F.	F.	NNP
cord-285262-690kpupt	520	26	)	)	-RRB-
cord-285262-690kpupt	520	27	tularensis	tularensis	NNP
cord-285262-690kpupt	520	28	(	(	-LRB-
cord-285262-690kpupt	520	29	Kim	Kim	NNP
cord-285262-690kpupt	520	30	et	et	NNP
cord-285262-690kpupt	520	31	al	al	NNP
cord-285262-690kpupt	520	32	.	.	NNP
cord-285262-690kpupt	520	33	,	,	,
cord-285262-690kpupt	520	34	2010	2010	CD
cord-285262-690kpupt	520	35	;	;	:
cord-285262-690kpupt	520	36	Rathinam	Rathinam	NNP
cord-285262-690kpupt	520	37	et	et	NNP
cord-285262-690kpupt	520	38	al	al	NNP
cord-285262-690kpupt	520	39	.	.	NNP
cord-285262-690kpupt	520	40	,	,	,
cord-285262-690kpupt	520	41	2010	2010	CD
cord-285262-690kpupt	520	42	)	)	-RRB-
cord-285262-690kpupt	520	43	and	and	CC
cord-285262-690kpupt	520	44	Brucella	Brucella	NNP
cord-285262-690kpupt	520	45	abortus	abortus	NN
cord-285262-690kpupt	520	46	infection	infection	NN
cord-285262-690kpupt	521	1	(	(	-LRB-
cord-285262-690kpupt	521	2	Costa	Costa	NNP
cord-285262-690kpupt	521	3	Franco	Franco	NNP
cord-285262-690kpupt	521	4	et	et	NNP
cord-285262-690kpupt	521	5	al	al	NNP
cord-285262-690kpupt	521	6	.	.	NNP
cord-285262-690kpupt	521	7	,	,	,
cord-285262-690kpupt	521	8	2019	2019	CD
cord-285262-690kpupt	521	9	)	)	-RRB-
cord-285262-690kpupt	521	10	.	.	.
cord-285262-690kpupt	522	1	Since	since	IN
cord-285262-690kpupt	522	2	the	the	DT
cord-285262-690kpupt	522	3	recognition	recognition	NN
cord-285262-690kpupt	522	4	by	by	IN
cord-285262-690kpupt	522	5	AIM2	AIM2	NNP
cord-285262-690kpupt	522	6	is	be	VBZ
cord-285262-690kpupt	522	7	fully	fully	RB
cord-285262-690kpupt	522	8	dependent	dependent	JJ
cord-285262-690kpupt	522	9	on	on	IN
cord-285262-690kpupt	522	10	the	the	DT
cord-285262-690kpupt	522	11	availability	availability	NN
cord-285262-690kpupt	522	12	of	of	IN
cord-285262-690kpupt	522	13	cytosolic	cytosolic	JJ
cord-285262-690kpupt	522	14	DNA	dna	NN
cord-285262-690kpupt	522	15	,	,	,
cord-285262-690kpupt	522	16	strains	strain	NNS
cord-285262-690kpupt	522	17	engineered	engineer	VBN
cord-285262-690kpupt	522	18	to	to	TO
cord-285262-690kpupt	522	19	lyse	lyse	VB
cord-285262-690kpupt	522	20	in	in	IN
cord-285262-690kpupt	522	21	the	the	DT
cord-285262-690kpupt	522	22	cytosol	cytosol	NN
cord-285262-690kpupt	522	23	can	can	MD
cord-285262-690kpupt	522	24	induce	induce	VB
cord-285262-690kpupt	522	25	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	522	26	more	more	RBR
cord-285262-690kpupt	522	27	efficiently	efficiently	RB
cord-285262-690kpupt	523	1	(	(	-LRB-
cord-285262-690kpupt	523	2	Sauer	Sauer	NNP
cord-285262-690kpupt	523	3	et	et	NNP
cord-285262-690kpupt	523	4	al	al	NNP
cord-285262-690kpupt	523	5	.	.	NNP
cord-285262-690kpupt	523	6	,	,	,
cord-285262-690kpupt	523	7	2010	2010	CD
cord-285262-690kpupt	523	8	)	)	-RRB-
cord-285262-690kpupt	523	9	.	.	.
cord-285262-690kpupt	524	1	Conversely	conversely	RB
cord-285262-690kpupt	524	2	,	,	,
cord-285262-690kpupt	524	3	in	in	IN
cord-285262-690kpupt	524	4	response	response	NN
cord-285262-690kpupt	524	5	to	to	IN
cord-285262-690kpupt	524	6	a	a	DT
cord-285262-690kpupt	524	7	naturally	naturally	RB
cord-285262-690kpupt	524	8	-	-	HYPH
cord-285262-690kpupt	524	9	occurring	occur	VBG
cord-285262-690kpupt	524	10	infection	infection	NN
cord-285262-690kpupt	524	11	by	by	IN
cord-285262-690kpupt	524	12	non	non	JJ
cord-285262-690kpupt	524	13	-	-	JJ
cord-285262-690kpupt	524	14	lysing	lysing	JJ
cord-285262-690kpupt	524	15	strains	strain	NNS
cord-285262-690kpupt	524	16	,	,	,
cord-285262-690kpupt	524	17	including	include	VBG
cord-285262-690kpupt	524	18	F.	F.	NNP
cord-285262-690kpupt	524	19	novicida	novicida	NNP
cord-285262-690kpupt	524	20	,	,	,
cord-285262-690kpupt	524	21	F.	F.	NNP
cord-285262-690kpupt	524	22	tularensis	tularensis	NNP
cord-285262-690kpupt	524	23	(	(	-LRB-
cord-285262-690kpupt	524	24	Man	Man	NNP
cord-285262-690kpupt	524	25	et	et	NNP
cord-285262-690kpupt	524	26	al	al	NNP
cord-285262-690kpupt	524	27	.	.	NNP
cord-285262-690kpupt	524	28	,	,	,
cord-285262-690kpupt	524	29	2015	2015	CD
cord-285262-690kpupt	524	30	)	)	-RRB-
cord-285262-690kpupt	524	31	and	and	CC
cord-285262-690kpupt	524	32	Chlamydia	Chlamydia	NNP
cord-285262-690kpupt	524	33	trachomatis	trachomatis	NN
cord-285262-690kpupt	524	34	(	(	-LRB-
cord-285262-690kpupt	524	35	Finethy	Finethy	NNP
cord-285262-690kpupt	524	36	et	et	NNP
cord-285262-690kpupt	524	37	al	al	NNP
cord-285262-690kpupt	524	38	.	.	NNP
cord-285262-690kpupt	524	39	,	,	,
cord-285262-690kpupt	524	40	2015	2015	CD
cord-285262-690kpupt	524	41	)	)	-RRB-
cord-285262-690kpupt	525	1	the	the	DT
cord-285262-690kpupt	525	2	cytosolic	cytosolic	JJ
cord-285262-690kpupt	525	3	release	release	NN
cord-285262-690kpupt	525	4	of	of	IN
cord-285262-690kpupt	525	5	the	the	DT
cord-285262-690kpupt	525	6	bacterial	bacterial	JJ
cord-285262-690kpupt	525	7	DNA	dna	NN
cord-285262-690kpupt	525	8	is	be	VBZ
cord-285262-690kpupt	525	9	facilitated	facilitate	VBN
cord-285262-690kpupt	525	10	by	by	IN
cord-285262-690kpupt	525	11	the	the	DT
cord-285262-690kpupt	525	12	TLR	TLR	NNP
cord-285262-690kpupt	525	13	mediated	mediate	VBN
cord-285262-690kpupt	525	14	GBPs	gbp	NNS
cord-285262-690kpupt	525	15	,	,	,
cord-285262-690kpupt	525	16	hence	hence	RB
cord-285262-690kpupt	525	17	supporting	support	VBG
cord-285262-690kpupt	525	18	the	the	DT
cord-285262-690kpupt	525	19	relevance	relevance	NN
cord-285262-690kpupt	525	20	of	of	IN
cord-285262-690kpupt	525	21	the	the	DT
cord-285262-690kpupt	525	22	IFN	IFN	NNP
cord-285262-690kpupt	525	23	dependent	dependent	JJ
cord-285262-690kpupt	525	24	priming	prime	VBG
cord-285262-690kpupt	525	25	events	event	NNS
cord-285262-690kpupt	525	26	to	to	TO
cord-285262-690kpupt	525	27	activate	activate	VB
cord-285262-690kpupt	525	28	this	this	DT
cord-285262-690kpupt	525	29	inflammasome	inflammasome	NN
cord-285262-690kpupt	525	30	.	.	.
cord-285262-690kpupt	526	1	4.3.6	4.3.6	CD
cord-285262-690kpupt	526	2	Cross	Cross	NNP
cord-285262-690kpupt	526	3	talk	talk	NN
cord-285262-690kpupt	526	4	between	between	IN
cord-285262-690kpupt	526	5	inflammatory	inflammatory	JJ
cord-285262-690kpupt	526	6	and	and	CC
cord-285262-690kpupt	526	7	apoptotic	apoptotic	JJ
cord-285262-690kpupt	526	8	cell	cell	NN
cord-285262-690kpupt	526	9	death	death	NN
cord-285262-690kpupt	526	10	pathways	pathway	NNS
cord-285262-690kpupt	527	1	A	a	DT
cord-285262-690kpupt	527	2	study	study	NN
cord-285262-690kpupt	527	3	on	on	IN
cord-285262-690kpupt	527	4	caspase-1	caspase-1	NNP
cord-285262-690kpupt	527	5	deficient	deficient	JJ
cord-285262-690kpupt	527	6	murine	murine	JJ
cord-285262-690kpupt	527	7	macrophages	macrophage	NNS
cord-285262-690kpupt	527	8	implicates	implicate	VBZ
cord-285262-690kpupt	527	9	the	the	DT
cord-285262-690kpupt	527	10	existence	existence	NN
cord-285262-690kpupt	527	11	of	of	IN
cord-285262-690kpupt	527	12	the	the	DT
cord-285262-690kpupt	527	13	cross	cross	NN
cord-285262-690kpupt	527	14	talk	talk	NN
cord-285262-690kpupt	527	15	between	between	IN
cord-285262-690kpupt	527	16	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	527	17	and	and	CC
cord-285262-690kpupt	527	18	apoptotic	apoptotic	JJ
cord-285262-690kpupt	527	19	caspases	caspase	NNS
cord-285262-690kpupt	527	20	.	.	.
cord-285262-690kpupt	528	1	In	in	IN
cord-285262-690kpupt	528	2	the	the	DT
cord-285262-690kpupt	528	3	absence	absence	NN
cord-285262-690kpupt	528	4	of	of	IN
cord-285262-690kpupt	528	5	caspase-1	caspase-1	NNP
cord-285262-690kpupt	528	6	,	,	,
cord-285262-690kpupt	528	7	the	the	DT
cord-285262-690kpupt	528	8	stimulation	stimulation	NN
cord-285262-690kpupt	528	9	of	of	IN
cord-285262-690kpupt	528	10	the	the	DT
cord-285262-690kpupt	528	11	AIM2	AIM2	NNP
cord-285262-690kpupt	528	12	/	/	SYM
cord-285262-690kpupt	528	13	ASC	ASC	NNP
cord-285262-690kpupt	528	14	axis	axis	NN
cord-285262-690kpupt	528	15	by	by	IN
cord-285262-690kpupt	528	16	F.	F.	NNP
cord-285262-690kpupt	528	17	tularensis	tularensis	NNP
cord-285262-690kpupt	528	18	leads	lead	VBZ
cord-285262-690kpupt	528	19	to	to	IN
cord-285262-690kpupt	528	20	caspase-8	caspase-8	JJ
cord-285262-690kpupt	528	21	cleavage	cleavage	NN
cord-285262-690kpupt	528	22	and	and	CC
cord-285262-690kpupt	528	23	apoptosis	apoptosis	NN
cord-285262-690kpupt	528	24	,	,	,
cord-285262-690kpupt	528	25	which	which	WDT
cord-285262-690kpupt	528	26	can	can	MD
cord-285262-690kpupt	528	27	restrict	restrict	VB
cord-285262-690kpupt	528	28	bacterial	bacterial	JJ
cord-285262-690kpupt	528	29	replication	replication	NN
cord-285262-690kpupt	528	30	in	in	IN
cord-285262-690kpupt	528	31	vitro	vitro	FW
cord-285262-690kpupt	528	32	(	(	-LRB-
cord-285262-690kpupt	529	1	Pierini	Pierini	NNP
cord-285262-690kpupt	529	2	et	et	NNP
cord-285262-690kpupt	529	3	al	al	NNP
cord-285262-690kpupt	529	4	.	.	NNP
cord-285262-690kpupt	529	5	,	,	,
cord-285262-690kpupt	529	6	2012	2012	CD
cord-285262-690kpupt	529	7	)	)	-RRB-
cord-285262-690kpupt	529	8	.	.	.
cord-285262-690kpupt	530	1	The	the	DT
cord-285262-690kpupt	530	2	mechanistic	mechanistic	JJ
cord-285262-690kpupt	530	3	details	detail	NNS
cord-285262-690kpupt	530	4	of	of	IN
cord-285262-690kpupt	530	5	the	the	DT
cord-285262-690kpupt	530	6	activation	activation	NN
cord-285262-690kpupt	530	7	,	,	,
cord-285262-690kpupt	530	8	however	however	RB
cord-285262-690kpupt	530	9	,	,	,
cord-285262-690kpupt	530	10	still	still	RB
cord-285262-690kpupt	530	11	need	need	VBP
cord-285262-690kpupt	530	12	to	to	TO
cord-285262-690kpupt	530	13	be	be	VB
cord-285262-690kpupt	530	14	elucidated	elucidate	VBN
cord-285262-690kpupt	530	15	.	.	.
cord-285262-690kpupt	531	1	Surprisingly	surprisingly	RB
cord-285262-690kpupt	531	2	,	,	,
cord-285262-690kpupt	531	3	the	the	DT
cord-285262-690kpupt	531	4	loss	loss	NN
cord-285262-690kpupt	531	5	of	of	IN
cord-285262-690kpupt	531	6	caspase-1	caspase-1	NNP
cord-285262-690kpupt	531	7	results	result	NNS
cord-285262-690kpupt	531	8	in	in	IN
cord-285262-690kpupt	531	9	faster	fast	JJR
cord-285262-690kpupt	531	10	kinetics	kinetic	NNS
cord-285262-690kpupt	531	11	of	of	IN
cord-285262-690kpupt	531	12	the	the	DT
cord-285262-690kpupt	531	13	AIM-2	AIM-2	NNP
cord-285262-690kpupt	531	14	speck	speck	NN
cord-285262-690kpupt	531	15	formation	formation	NN
cord-285262-690kpupt	531	16	,	,	,
cord-285262-690kpupt	531	17	indicating	indicate	VBG
cord-285262-690kpupt	531	18	the	the	DT
cord-285262-690kpupt	531	19	presence	presence	NN
cord-285262-690kpupt	531	20	of	of	IN
cord-285262-690kpupt	531	21	a	a	DT
cord-285262-690kpupt	531	22	caspase-1	caspase-1	NNP
cord-285262-690kpupt	531	23	dependent	dependent	JJ
cord-285262-690kpupt	531	24	negative	negative	JJ
cord-285262-690kpupt	531	25	feedback	feedback	NN
cord-285262-690kpupt	531	26	loop	loop	NN
cord-285262-690kpupt	531	27	(	(	-LRB-
cord-285262-690kpupt	531	28	Juruj	Juruj	NNP
cord-285262-690kpupt	531	29	et	et	NNP
cord-285262-690kpupt	531	30	al	al	NNP
cord-285262-690kpupt	531	31	.	.	NNP
cord-285262-690kpupt	531	32	,	,	,
cord-285262-690kpupt	531	33	2013	2013	CD
cord-285262-690kpupt	531	34	)	)	-RRB-
cord-285262-690kpupt	531	35	.	.	.
cord-285262-690kpupt	532	1	We	-PRON-	PRP
cord-285262-690kpupt	532	2	therefore	therefore	RB
cord-285262-690kpupt	532	3	speculate	speculate	VBP
cord-285262-690kpupt	532	4	that	that	IN
cord-285262-690kpupt	532	5	an	an	DT
cord-285262-690kpupt	532	6	over	over	IN
cord-285262-690kpupt	532	7	-	-	HYPH
cord-285262-690kpupt	532	8	activation	activation	NN
cord-285262-690kpupt	532	9	of	of	IN
cord-285262-690kpupt	532	10	the	the	DT
cord-285262-690kpupt	532	11	AIM2	AIM2	NNP
cord-285262-690kpupt	532	12	speck	speck	NN
cord-285262-690kpupt	532	13	formation	formation	NN
cord-285262-690kpupt	532	14	may	may	MD
cord-285262-690kpupt	532	15	result	result	VB
cord-285262-690kpupt	532	16	in	in	IN
cord-285262-690kpupt	532	17	the	the	DT
cord-285262-690kpupt	532	18	loss	loss	NN
cord-285262-690kpupt	532	19	of	of	IN
cord-285262-690kpupt	532	20	specificity	specificity	NN
cord-285262-690kpupt	532	21	,	,	,
cord-285262-690kpupt	532	22	consequently	consequently	RB
cord-285262-690kpupt	532	23	leading	lead	VBG
cord-285262-690kpupt	532	24	to	to	IN
cord-285262-690kpupt	532	25	the	the	DT
cord-285262-690kpupt	532	26	recruitment	recruitment	NN
cord-285262-690kpupt	532	27	of	of	IN
cord-285262-690kpupt	532	28	other	other	JJ
cord-285262-690kpupt	532	29	initiator	initiator	NN
cord-285262-690kpupt	532	30	caspases	caspase	NNS
cord-285262-690kpupt	532	31	into	into	IN
cord-285262-690kpupt	532	32	the	the	DT
cord-285262-690kpupt	532	33	complex	complex	NN
cord-285262-690kpupt	532	34	.	.	.
cord-285262-690kpupt	533	1	In	in	IN
cord-285262-690kpupt	533	2	fact	fact	NN
cord-285262-690kpupt	533	3	,	,	,
cord-285262-690kpupt	533	4	the	the	DT
cord-285262-690kpupt	533	5	recruitment	recruitment	NN
cord-285262-690kpupt	533	6	of	of	IN
cord-285262-690kpupt	533	7	caspase-8	caspase-8	NNP
cord-285262-690kpupt	533	8	into	into	IN
cord-285262-690kpupt	533	9	the	the	DT
cord-285262-690kpupt	533	10	NLRP3-ASC	NLRP3-ASC	NNP
cord-285262-690kpupt	533	11	inflammasome	inflammasome	NN
cord-285262-690kpupt	533	12	has	have	VBZ
cord-285262-690kpupt	533	13	been	be	VBN
cord-285262-690kpupt	533	14	demonstrated	demonstrate	VBN
cord-285262-690kpupt	533	15	in	in	IN
cord-285262-690kpupt	533	16	LPS	LPS	NNP
cord-285262-690kpupt	533	17	and	and	CC
cord-285262-690kpupt	533	18	nigericin	nigericin	NNS
cord-285262-690kpupt	533	19	stimulated	stimulate	VBD
cord-285262-690kpupt	533	20	murine	murine	JJ
cord-285262-690kpupt	533	21	bone	bone	NN
cord-285262-690kpupt	533	22	marrow	marrow	NN
cord-285262-690kpupt	533	23	-	-	HYPH
cord-285262-690kpupt	533	24	derived	derive	VBN
cord-285262-690kpupt	533	25	dendritic	dendritic	JJ
cord-285262-690kpupt	533	26	cells	cell	NNS
cord-285262-690kpupt	533	27	in	in	IN
cord-285262-690kpupt	533	28	the	the	DT
cord-285262-690kpupt	533	29	absence	absence	NN
cord-285262-690kpupt	533	30	of	of	IN
cord-285262-690kpupt	533	31	caspase-1	caspase-1	NNP
cord-285262-690kpupt	533	32	and	and	CC
cord-285262-690kpupt	533	33	-11	-11	XX
cord-285262-690kpupt	534	1	(	(	-LRB-
cord-285262-690kpupt	534	2	Antonopoulos	Antonopoulos	NNP
cord-285262-690kpupt	534	3	et	et	FW
cord-285262-690kpupt	534	4	al	al	NNP
cord-285262-690kpupt	534	5	.	.	NNP
cord-285262-690kpupt	534	6	,	,	,
cord-285262-690kpupt	534	7	2015	2015	CD
cord-285262-690kpupt	534	8	)	)	-RRB-
cord-285262-690kpupt	534	9	.	.	.
cord-285262-690kpupt	535	1	Furthermore	furthermore	RB
cord-285262-690kpupt	535	2	,	,	,
cord-285262-690kpupt	535	3	the	the	DT
cord-285262-690kpupt	535	4	Yersinia	Yersinia	NNP
cord-285262-690kpupt	535	5	effector	effector	NN
cord-285262-690kpupt	535	6	protein	protein	NN
cord-285262-690kpupt	535	7	YopJ	YopJ	NNP
cord-285262-690kpupt	535	8	has	have	VBZ
cord-285262-690kpupt	535	9	been	be	VBN
cord-285262-690kpupt	535	10	shown	show	VBN
cord-285262-690kpupt	535	11	to	to	TO
cord-285262-690kpupt	535	12	inhibit	inhibit	VB
cord-285262-690kpupt	535	13	TAK1	TAK1	NNP
cord-285262-690kpupt	535	14	and	and	CC
cord-285262-690kpupt	535	15	IKK	IKK	NNP
cord-285262-690kpupt	535	16	,	,	,
cord-285262-690kpupt	535	17	which	which	WDT
cord-285262-690kpupt	535	18	in	in	IN
cord-285262-690kpupt	535	19	turn	turn	NN
cord-285262-690kpupt	535	20	led	lead	VBD
cord-285262-690kpupt	535	21	to	to	IN
cord-285262-690kpupt	535	22	RIPK1	RIPK1	NNP
cord-285262-690kpupt	535	23	and	and	CC
cord-285262-690kpupt	535	24	caspase-8	caspase-8	NNP
cord-285262-690kpupt	535	25	activation	activation	NN
cord-285262-690kpupt	535	26	in	in	IN
cord-285262-690kpupt	535	27	macrophages	macrophage	NNS
cord-285262-690kpupt	535	28	.	.	.
cord-285262-690kpupt	536	1	This	this	DT
cord-285262-690kpupt	536	2	and	and	CC
cord-285262-690kpupt	536	3	another	another	DT
cord-285262-690kpupt	536	4	group	group	NN
cord-285262-690kpupt	536	5	simultaneously	simultaneously	RB
cord-285262-690kpupt	536	6	published	publish	VBD
cord-285262-690kpupt	536	7	the	the	DT
cord-285262-690kpupt	536	8	finding	finding	NN
cord-285262-690kpupt	536	9	that	that	WDT
cord-285262-690kpupt	536	10	caspase-8	caspase-8	NNP
cord-285262-690kpupt	536	11	could	could	MD
cord-285262-690kpupt	536	12	directly	directly	RB
cord-285262-690kpupt	536	13	cleave	cleave	VB
cord-285262-690kpupt	536	14	GSDMD	GSDMD	NNP
cord-285262-690kpupt	536	15	,	,	,
cord-285262-690kpupt	536	16	leading	lead	VBG
cord-285262-690kpupt	536	17	to	to	IN
cord-285262-690kpupt	536	18	pyroptotic	pyroptotic	JJ
cord-285262-690kpupt	536	19	cell	cell	NN
cord-285262-690kpupt	536	20	death	death	NN
cord-285262-690kpupt	536	21	(	(	-LRB-
cord-285262-690kpupt	536	22	Orning	Orning	NNP
cord-285262-690kpupt	536	23	et	et	FW
cord-285262-690kpupt	536	24	al	al	NNP
cord-285262-690kpupt	536	25	.	.	NNP
cord-285262-690kpupt	536	26	,	,	,
cord-285262-690kpupt	536	27	2018	2018	CD
cord-285262-690kpupt	536	28	;	;	:
cord-285262-690kpupt	536	29	Sarhan	Sarhan	NNP
cord-285262-690kpupt	536	30	et	et	NNP
cord-285262-690kpupt	536	31	al	al	NNP
cord-285262-690kpupt	536	32	.	.	NNP
cord-285262-690kpupt	536	33	,	,	,
cord-285262-690kpupt	536	34	2018	2018	CD
cord-285262-690kpupt	536	35	)	)	-RRB-
cord-285262-690kpupt	536	36	.	.	.
cord-285262-690kpupt	537	1	Finally	finally	RB
cord-285262-690kpupt	537	2	,	,	,
cord-285262-690kpupt	537	3	in	in	IN
cord-285262-690kpupt	537	4	a	a	DT
cord-285262-690kpupt	537	5	third	third	JJ
cord-285262-690kpupt	537	6	study	study	NN
cord-285262-690kpupt	537	7	the	the	DT
cord-285262-690kpupt	537	8	NLRC4	NLRC4	NNP
cord-285262-690kpupt	537	9	dependent	dependent	JJ
cord-285262-690kpupt	537	10	assembly	assembly	NN
cord-285262-690kpupt	537	11	of	of	IN
cord-285262-690kpupt	537	12	the	the	DT
cord-285262-690kpupt	537	13	ASC	ASC	NNP
cord-285262-690kpupt	537	14	caspase-8	caspase-8	NNP
cord-285262-690kpupt	537	15	inflammasome	inflammasome	NN
cord-285262-690kpupt	537	16	has	have	VBZ
cord-285262-690kpupt	537	17	been	be	VBN
cord-285262-690kpupt	537	18	demonstrated	demonstrate	VBN
cord-285262-690kpupt	537	19	in	in	IN
cord-285262-690kpupt	537	20	Salmonella	Salmonella	NNP
cord-285262-690kpupt	537	21	typhimurium	typhimurium	NN
cord-285262-690kpupt	537	22	infected	infected	JJ
cord-285262-690kpupt	537	23	cells	cell	NNS
cord-285262-690kpupt	537	24	(	(	-LRB-
cord-285262-690kpupt	537	25	Man	man	NN
cord-285262-690kpupt	537	26	et	et	NNP
cord-285262-690kpupt	537	27	al	al	NNP
cord-285262-690kpupt	537	28	.	.	NNP
cord-285262-690kpupt	537	29	,	,	,
cord-285262-690kpupt	537	30	2013	2013	CD
cord-285262-690kpupt	537	31	)	)	-RRB-
cord-285262-690kpupt	537	32	.	.	.
cord-285262-690kpupt	538	1	In	in	IN
cord-285262-690kpupt	538	2	this	this	DT
cord-285262-690kpupt	538	3	review	review	NN
cord-285262-690kpupt	538	4	,	,	,
cord-285262-690kpupt	538	5	we	-PRON-	PRP
cord-285262-690kpupt	538	6	discussed	discuss	VBD
cord-285262-690kpupt	538	7	the	the	DT
cord-285262-690kpupt	538	8	role	role	NN
cord-285262-690kpupt	538	9	of	of	IN
cord-285262-690kpupt	538	10	three	three	CD
cord-285262-690kpupt	538	11	major	major	JJ
cord-285262-690kpupt	538	12	cell	cell	NN
cord-285262-690kpupt	538	13	death	death	NN
cord-285262-690kpupt	538	14	pathways	pathway	NNS
cord-285262-690kpupt	538	15	:	:	:
cord-285262-690kpupt	538	16	apoptosis	apoptosis	NN
cord-285262-690kpupt	538	17	,	,	,
cord-285262-690kpupt	538	18	necroptosis	necroptosis	NNP
cord-285262-690kpupt	538	19	,	,	,
cord-285262-690kpupt	538	20	and	and	CC
cord-285262-690kpupt	538	21	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	538	22	in	in	IN
cord-285262-690kpupt	538	23	the	the	DT
cord-285262-690kpupt	538	24	context	context	NN
cord-285262-690kpupt	538	25	of	of	IN
cord-285262-690kpupt	538	26	viral	viral	JJ
cord-285262-690kpupt	538	27	and	and	CC
cord-285262-690kpupt	538	28	bacterial	bacterial	JJ
cord-285262-690kpupt	538	29	infections	infection	NNS
cord-285262-690kpupt	538	30	.	.	.
cord-285262-690kpupt	539	1	The	the	DT
cord-285262-690kpupt	539	2	past	past	JJ
cord-285262-690kpupt	539	3	few	few	JJ
cord-285262-690kpupt	539	4	years	year	NNS
cord-285262-690kpupt	539	5	of	of	IN
cord-285262-690kpupt	539	6	research	research	NN
cord-285262-690kpupt	539	7	in	in	IN
cord-285262-690kpupt	539	8	the	the	DT
cord-285262-690kpupt	539	9	field	field	NN
cord-285262-690kpupt	539	10	of	of	IN
cord-285262-690kpupt	539	11	host	host	NN
cord-285262-690kpupt	539	12	-	-	HYPH
cord-285262-690kpupt	539	13	pathogen	pathogen	NN
cord-285262-690kpupt	539	14	interaction	interaction	NN
cord-285262-690kpupt	539	15	demonstrates	demonstrate	VBZ
cord-285262-690kpupt	539	16	us	-PRON-	PRP
cord-285262-690kpupt	539	17	that	that	IN
cord-285262-690kpupt	539	18	the	the	DT
cord-285262-690kpupt	539	19	connection	connection	NN
cord-285262-690kpupt	539	20	between	between	IN
cord-285262-690kpupt	539	21	the	the	DT
cord-285262-690kpupt	539	22	pathogens	pathogen	NNS
cord-285262-690kpupt	539	23	and	and	CC
cord-285262-690kpupt	539	24	the	the	DT
cord-285262-690kpupt	539	25	host	host	NN
cord-285262-690kpupt	539	26	cell	cell	NN
cord-285262-690kpupt	539	27	death	death	NN
cord-285262-690kpupt	539	28	signaling	signaling	NN
cord-285262-690kpupt	539	29	is	be	VBZ
cord-285262-690kpupt	539	30	more	more	RBR
cord-285262-690kpupt	539	31	complex	complex	JJ
cord-285262-690kpupt	539	32	than	than	IN
cord-285262-690kpupt	539	33	previously	previously	RB
cord-285262-690kpupt	539	34	expected	expect	VBN
cord-285262-690kpupt	539	35	.	.	.
cord-285262-690kpupt	540	1	The	the	DT
cord-285262-690kpupt	540	2	complexity	complexity	NN
cord-285262-690kpupt	540	3	of	of	IN
cord-285262-690kpupt	540	4	the	the	DT
cord-285262-690kpupt	540	5	apoptotic	apoptotic	JJ
cord-285262-690kpupt	540	6	,	,	,
cord-285262-690kpupt	540	7	necroptotic	necroptotic	JJ
cord-285262-690kpupt	540	8	,	,	,
cord-285262-690kpupt	540	9	and	and	CC
cord-285262-690kpupt	540	10	pyroptotic	pyroptotic	JJ
cord-285262-690kpupt	540	11	signaling	signal	VBG
cord-285262-690kpupt	540	12	pathways	pathway	NNS
cord-285262-690kpupt	540	13	,	,	,
cord-285262-690kpupt	540	14	the	the	DT
cord-285262-690kpupt	540	15	presence	presence	NN
cord-285262-690kpupt	540	16	of	of	IN
cord-285262-690kpupt	540	17	the	the	DT
cord-285262-690kpupt	540	18	cross	cross	NN
cord-285262-690kpupt	540	19	talks	talk	NNS
cord-285262-690kpupt	540	20	and	and	CC
cord-285262-690kpupt	540	21	the	the	DT
cord-285262-690kpupt	540	22	feedback	feedback	NN
cord-285262-690kpupt	540	23	mechanisms	mechanism	NNS
cord-285262-690kpupt	540	24	reflect	reflect	VBP
cord-285262-690kpupt	540	25	the	the	DT
cord-285262-690kpupt	540	26	significance	significance	NN
cord-285262-690kpupt	540	27	of	of	IN
cord-285262-690kpupt	540	28	a	a	DT
cord-285262-690kpupt	540	29	continuously	continuously	RB
cord-285262-690kpupt	540	30	running	run	VBG
cord-285262-690kpupt	540	31	evolutionary	evolutionary	JJ
cord-285262-690kpupt	540	32	race	race	NN
cord-285262-690kpupt	540	33	between	between	IN
cord-285262-690kpupt	540	34	the	the	DT
cord-285262-690kpupt	540	35	pathogens	pathogen	NNS
cord-285262-690kpupt	540	36	and	and	CC
cord-285262-690kpupt	540	37	their	-PRON-	PRP$
cord-285262-690kpupt	540	38	natural	natural	JJ
cord-285262-690kpupt	540	39	hosts	host	NNS
cord-285262-690kpupt	540	40	.	.	.
cord-285262-690kpupt	541	1	This	this	DT
cord-285262-690kpupt	541	2	is	be	VBZ
cord-285262-690kpupt	541	3	best	well	RBS
cord-285262-690kpupt	541	4	proven	prove	VBN
cord-285262-690kpupt	541	5	by	by	IN
cord-285262-690kpupt	541	6	the	the	DT
cord-285262-690kpupt	541	7	observations	observation	NNS
cord-285262-690kpupt	541	8	that	that	WDT
cord-285262-690kpupt	541	9	successful	successful	JJ
cord-285262-690kpupt	541	10	human	human	JJ
cord-285262-690kpupt	541	11	pathogens	pathogen	NNS
cord-285262-690kpupt	541	12	developed	develop	VBD
cord-285262-690kpupt	541	13	counter	counter	NN
cord-285262-690kpupt	541	14	measures	measure	NNS
cord-285262-690kpupt	541	15	to	to	TO
cord-285262-690kpupt	541	16	attenuate	attenuate	VB
cord-285262-690kpupt	541	17	the	the	DT
cord-285262-690kpupt	541	18	cell	cell	NN
cord-285262-690kpupt	541	19	death	death	NN
cord-285262-690kpupt	541	20	induction	induction	NN
cord-285262-690kpupt	541	21	potential	potential	NN
cord-285262-690kpupt	541	22	of	of	IN
cord-285262-690kpupt	541	23	the	the	DT
cord-285262-690kpupt	541	24	host	host	NN
cord-285262-690kpupt	541	25	,	,	,
cord-285262-690kpupt	541	26	whereas	whereas	IN
cord-285262-690kpupt	541	27	other	other	JJ
cord-285262-690kpupt	541	28	pathogens	pathogen	NNS
cord-285262-690kpupt	541	29	developed	develop	VBD
cord-285262-690kpupt	541	30	strategies	strategy	NNS
cord-285262-690kpupt	541	31	to	to	TO
cord-285262-690kpupt	541	32	hijack	hijack	VB
cord-285262-690kpupt	541	33	the	the	DT
cord-285262-690kpupt	541	34	cell	cell	NN
cord-285262-690kpupt	541	35	death	death	NN
cord-285262-690kpupt	541	36	machinery	machinery	NN
cord-285262-690kpupt	541	37	in	in	IN
cord-285262-690kpupt	541	38	order	order	NN
cord-285262-690kpupt	541	39	to	to	TO
cord-285262-690kpupt	541	40	accomplish	accomplish	VB
cord-285262-690kpupt	541	41	the	the	DT
cord-285262-690kpupt	541	42	targeted	target	VBN
cord-285262-690kpupt	541	43	destruction	destruction	NN
cord-285262-690kpupt	541	44	of	of	IN
cord-285262-690kpupt	541	45	the	the	DT
cord-285262-690kpupt	541	46	defense	defense	NN
cord-285262-690kpupt	541	47	mechanism	mechanism	NN
cord-285262-690kpupt	541	48	of	of	IN
cord-285262-690kpupt	541	49	the	the	DT
cord-285262-690kpupt	541	50	host	host	NN
cord-285262-690kpupt	541	51	.	.	.
cord-285262-690kpupt	542	1	Thus	thus	RB
cord-285262-690kpupt	542	2	,	,	,
cord-285262-690kpupt	542	3	looking	look	VBG
cord-285262-690kpupt	542	4	it	-PRON-	PRP
cord-285262-690kpupt	542	5	from	from	IN
cord-285262-690kpupt	542	6	an	an	DT
cord-285262-690kpupt	542	7	evolutionary	evolutionary	JJ
cord-285262-690kpupt	542	8	perspective	perspective	NN
cord-285262-690kpupt	542	9	,	,	,
cord-285262-690kpupt	542	10	the	the	DT
cord-285262-690kpupt	542	11	different	different	JJ
cord-285262-690kpupt	542	12	layers	layer	NNS
cord-285262-690kpupt	542	13	of	of	IN
cord-285262-690kpupt	542	14	cell	cell	NN
cord-285262-690kpupt	542	15	death	death	NN
cord-285262-690kpupt	542	16	pathways	pathway	NNS
cord-285262-690kpupt	542	17	can	can	MD
cord-285262-690kpupt	542	18	be	be	VB
cord-285262-690kpupt	542	19	interpreted	interpret	VBN
cord-285262-690kpupt	542	20	as	as	IN
cord-285262-690kpupt	542	21	different	different	JJ
cord-285262-690kpupt	542	22	evolutionary	evolutionary	JJ
cord-285262-690kpupt	542	23	steps	step	NNS
cord-285262-690kpupt	542	24	built	build	VBN
cord-285262-690kpupt	542	25	upon	upon	IN
cord-285262-690kpupt	542	26	each	each	DT
cord-285262-690kpupt	542	27	other	other	JJ
cord-285262-690kpupt	542	28	in	in	IN
cord-285262-690kpupt	542	29	response	response	NN
cord-285262-690kpupt	542	30	to	to	IN
cord-285262-690kpupt	542	31	a	a	DT
cord-285262-690kpupt	542	32	selective	selective	JJ
cord-285262-690kpupt	542	33	pathogen	pathogen	NN
cord-285262-690kpupt	542	34	insult	insult	NN
cord-285262-690kpupt	542	35	.	.	.
cord-285262-690kpupt	543	1	The	the	DT
cord-285262-690kpupt	543	2	better	well	JJR
cord-285262-690kpupt	543	3	understanding	understanding	NN
cord-285262-690kpupt	543	4	of	of	IN
cord-285262-690kpupt	543	5	these	these	DT
cord-285262-690kpupt	543	6	mechanisms	mechanism	NNS
cord-285262-690kpupt	543	7	can	can	MD
cord-285262-690kpupt	543	8	provide	provide	VB
cord-285262-690kpupt	543	9	us	us	NNP
cord-285262-690kpupt	543	10	novel	novel	JJ
cord-285262-690kpupt	543	11	strategies	strategy	NNS
cord-285262-690kpupt	543	12	to	to	IN
cord-285262-690kpupt	543	13	more	more	RBR
cord-285262-690kpupt	543	14	efficiently	efficiently	RB
cord-285262-690kpupt	543	15	treat	treat	VB
cord-285262-690kpupt	543	16	infectious	infectious	JJ
cord-285262-690kpupt	543	17	diseases	disease	NNS
cord-285262-690kpupt	543	18	in	in	IN
cord-285262-690kpupt	543	19	the	the	DT
cord-285262-690kpupt	543	20	future	future	NN
cord-285262-690kpupt	543	21	.	.	.
cord-285262-690kpupt	544	1	Caspase-11	Caspase-11	NNP
cord-285262-690kpupt	544	2	protects	protect	VBZ
cord-285262-690kpupt	544	3	against	against	IN
cord-285262-690kpupt	544	4	bacteria	bacteria	NNS
cord-285262-690kpupt	544	5	that	that	WDT
cord-285262-690kpupt	544	6	escape	escape	VBP
cord-285262-690kpupt	544	7	the	the	DT
cord-285262-690kpupt	544	8	vacuole	vacuole	NN
cord-285262-690kpupt	544	9	Recognition	Recognition	NNP
cord-285262-690kpupt	544	10	of	of	IN
cord-285262-690kpupt	544	11	doublestranded	doublestranded	NNP
cord-285262-690kpupt	544	12	RNA	RNA	NNP
cord-285262-690kpupt	544	13	and	and	CC
cord-285262-690kpupt	544	14	activation	activation	NN
cord-285262-690kpupt	544	15	of	of	IN
cord-285262-690kpupt	544	16	NF	NF	NNP
cord-285262-690kpupt	544	17	-	-	HYPH
cord-285262-690kpupt	544	18	kappaB	kappaB	NNP
cord-285262-690kpupt	544	19	by	by	IN
cord-285262-690kpupt	544	20	Toll	Toll	NNP
cord-285262-690kpupt	544	21	-	-	HYPH
cord-285262-690kpupt	544	22	like	like	JJ
cord-285262-690kpupt	544	23	receptor	receptor	NN
cord-285262-690kpupt	544	24	3	3	CD
cord-285262-690kpupt	544	25	Herpes	Herpes	NNP
cord-285262-690kpupt	544	26	simplex	simplex	NN
cord-285262-690kpupt	544	27	virus	virus	NN
cord-285262-690kpupt	544	28	1	1	CD
cord-285262-690kpupt	544	29	ICP6	ICP6	NNP
cord-285262-690kpupt	544	30	impedes	impede	VBZ
cord-285262-690kpupt	544	31	TNF	TNF	NNP
cord-285262-690kpupt	544	32	receptor	receptor	NN
cord-285262-690kpupt	544	33	1-induced	1-induced	CD
cord-285262-690kpupt	544	34	necrosome	necrosome	NNP
cord-285262-690kpupt	544	35	assembly	assembly	NN
cord-285262-690kpupt	544	36	during	during	IN
cord-285262-690kpupt	544	37	compartmentalization	compartmentalization	NN
cord-285262-690kpupt	544	38	to	to	IN
cord-285262-690kpupt	544	39	detergent	detergent	NN
cord-285262-690kpupt	544	40	-	-	HYPH
cord-285262-690kpupt	544	41	resistant	resistant	JJ
cord-285262-690kpupt	544	42	membrane	membrane	NN
cord-285262-690kpupt	544	43	vesicles	vesicle	NNS
cord-285262-690kpupt	544	44	Caspase-4	Caspase-4	NNP
cord-285262-690kpupt	545	1	disaggregates	disaggregates	NNP
cord-285262-690kpupt	545	2	lipopolysaccharide	lipopolysaccharide	NNP
cord-285262-690kpupt	545	3	micelles	micelle	NNS
cord-285262-690kpupt	545	4	via	via	IN
cord-285262-690kpupt	545	5	LPS	LPS	NNP
cord-285262-690kpupt	545	6	-	-	HYPH
cord-285262-690kpupt	545	7	CARD	card	NN
cord-285262-690kpupt	545	8	interaction	interaction	NN
cord-285262-690kpupt	545	9	Caspase-8	Caspase-8	NNP
cord-285262-690kpupt	545	10	as	as	IN
cord-285262-690kpupt	545	11	an	an	DT
cord-285262-690kpupt	545	12	effector	effector	NN
cord-285262-690kpupt	545	13	and	and	CC
cord-285262-690kpupt	545	14	regulator	regulator	NN
cord-285262-690kpupt	545	15	of	of	IN
cord-285262-690kpupt	545	16	NLRP3	NLRP3	NNP
cord-285262-690kpupt	545	17	inflammasome	inflammasome	NNP
cord-285262-690kpupt	545	18	signaling	signal	VBG
cord-285262-690kpupt	545	19	Necroptosis	Necroptosis	NNP
cord-285262-690kpupt	545	20	of	of	IN
cord-285262-690kpupt	545	21	infiltrated	infiltrate	VBN
cord-285262-690kpupt	545	22	macrophages	macrophage	NNS
cord-285262-690kpupt	545	23	drives	drive	VBZ
cord-285262-690kpupt	545	24	Yersinia	Yersinia	NNP
cord-285262-690kpupt	545	25	pestis	pestis	NN
cord-285262-690kpupt	545	26	dispersal	dispersal	NN
cord-285262-690kpupt	545	27	within	within	IN
cord-285262-690kpupt	545	28	buboes	bubo	NNS
cord-285262-690kpupt	545	29	Bacteria	Bacteria	NNS
cord-285262-690kpupt	545	30	and	and	CC
cord-285262-690kpupt	545	31	host	host	NN
cord-285262-690kpupt	545	32	interactions	interaction	NNS
cord-285262-690kpupt	545	33	in	in	IN
cord-285262-690kpupt	545	34	the	the	DT
cord-285262-690kpupt	545	35	gut	gut	NN
cord-285262-690kpupt	545	36	epithelial	epithelial	JJ
cord-285262-690kpupt	545	37	barrier	barrier	NN
cord-285262-690kpupt	546	1	The	the	DT
cord-285262-690kpupt	546	2	NLRP3	nlrp3	NN
cord-285262-690kpupt	546	3	inflammasome	inflammasome	NN
cord-285262-690kpupt	546	4	is	be	VBZ
cord-285262-690kpupt	546	5	upregulated	upregulate	VBN
cord-285262-690kpupt	546	6	in	in	IN
cord-285262-690kpupt	546	7	HIVinfected	hivinfecte	VBN
cord-285262-690kpupt	546	8	antiretroviral	antiretroviral	JJ
cord-285262-690kpupt	546	9	therapy	therapy	NN
cord-285262-690kpupt	546	10	-	-	HYPH
cord-285262-690kpupt	546	11	treated	treat	VBN
cord-285262-690kpupt	546	12	individuals	individual	NNS
cord-285262-690kpupt	546	13	with	with	IN
cord-285262-690kpupt	546	14	defective	defective	JJ
cord-285262-690kpupt	546	15	immune	immune	JJ
cord-285262-690kpupt	546	16	recovery	recovery	NN
cord-285262-690kpupt	546	17	Execution	execution	NN
cord-285262-690kpupt	546	18	of	of	IN
cord-285262-690kpupt	546	19	macrophage	macrophage	NN
cord-285262-690kpupt	546	20	apoptosis	apoptosis	NN
cord-285262-690kpupt	546	21	by	by	IN
cord-285262-690kpupt	546	22	PE_PGRS33	PE_PGRS33	NNP
cord-285262-690kpupt	546	23	of	of	IN
cord-285262-690kpupt	546	24	Mycobacterium	Mycobacterium	NNP
cord-285262-690kpupt	546	25	tuberculosis	tuberculosis	NN
cord-285262-690kpupt	546	26	is	be	VBZ
cord-285262-690kpupt	546	27	mediated	mediate	VBN
cord-285262-690kpupt	546	28	by	by	IN
cord-285262-690kpupt	546	29	Toll	toll	NN
cord-285262-690kpupt	546	30	-	-	HYPH
cord-285262-690kpupt	546	31	like	like	JJ
cord-285262-690kpupt	546	32	receptor	receptor	NN
cord-285262-690kpupt	546	33	2-dependent	2-dependent	CD
cord-285262-690kpupt	546	34	release	release	NN
cord-285262-690kpupt	546	35	of	of	IN
cord-285262-690kpupt	546	36	tumor	tumor	NN
cord-285262-690kpupt	546	37	necrosis	necrosis	NN
cord-285262-690kpupt	546	38	factor	factor	NN
cord-285262-690kpupt	546	39	-	-	HYPH
cord-285262-690kpupt	546	40	alpha	alpha	NN
cord-285262-690kpupt	546	41	A	a	DT
cord-285262-690kpupt	546	42	genome	genome	NN
cord-285262-690kpupt	546	43	-	-	HYPH
cord-285262-690kpupt	546	44	wide	wide	JJ
cord-285262-690kpupt	546	45	screen	screen	NN
cord-285262-690kpupt	547	1	identifies	identify	VBZ
cord-285262-690kpupt	547	2	IRF2	IRF2	NNP
cord-285262-690kpupt	547	3	as	as	IN
cord-285262-690kpupt	547	4	a	a	DT
cord-285262-690kpupt	547	5	key	key	JJ
cord-285262-690kpupt	547	6	regulator	regulator	NN
cord-285262-690kpupt	547	7	of	of	IN
cord-285262-690kpupt	547	8	caspase-4	caspase-4	NNP
cord-285262-690kpupt	547	9	in	in	IN
cord-285262-690kpupt	547	10	human	human	JJ
cord-285262-690kpupt	547	11	cells	cell	NNS
cord-285262-690kpupt	547	12	Macrophage	Macrophage	NNP
cord-285262-690kpupt	547	13	activation	activation	NN
cord-285262-690kpupt	547	14	redirects	redirect	VBZ
cord-285262-690kpupt	547	15	yersinia	yersinia	NN
cord-285262-690kpupt	547	16	-	-	HYPH
cord-285262-690kpupt	547	17	infected	infect	VBN
cord-285262-690kpupt	547	18	host	host	NN
cord-285262-690kpupt	547	19	cell	cell	NN
cord-285262-690kpupt	547	20	death	death	NN
cord-285262-690kpupt	547	21	from	from	IN
cord-285262-690kpupt	547	22	apoptosis	apoptosis	NN
cord-285262-690kpupt	547	23	to	to	IN
cord-285262-690kpupt	547	24	caspase-1-dependent	caspase-1-dependent	NNP
cord-285262-690kpupt	547	25	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	548	1	Nalp1b	Nalp1b	NNP
cord-285262-690kpupt	548	2	controls	control	VBZ
cord-285262-690kpupt	548	3	mouse	mouse	NN
cord-285262-690kpupt	548	4	macrophage	macrophage	NN
cord-285262-690kpupt	548	5	susceptibility	susceptibility	NN
cord-285262-690kpupt	548	6	to	to	IN
cord-285262-690kpupt	548	7	anthrax	anthrax	NN
cord-285262-690kpupt	548	8	lethal	lethal	JJ
cord-285262-690kpupt	548	9	toxin	toxin	NN
cord-285262-690kpupt	548	10	Caspase-2	Caspase-2	NNP
cord-285262-690kpupt	549	1	mediates	mediate	VBZ
cord-285262-690kpupt	549	2	a	a	DT
cord-285262-690kpupt	549	3	Brucella	Brucella	NNP
cord-285262-690kpupt	549	4	abortus	abortus	NN
cord-285262-690kpupt	549	5	RB51-induced	RB51-induced	NNP
cord-285262-690kpupt	549	6	hybrid	hybrid	JJ
cord-285262-690kpupt	549	7	cell	cell	NN
cord-285262-690kpupt	549	8	death	death	NN
cord-285262-690kpupt	549	9	having	have	VBG
cord-285262-690kpupt	549	10	features	feature	NNS
cord-285262-690kpupt	549	11	of	of	IN
cord-285262-690kpupt	549	12	apoptosis	apoptosis	NN
cord-285262-690kpupt	549	13	and	and	CC
cord-285262-690kpupt	549	14	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	549	15	Asc	Asc	NNP
cord-285262-690kpupt	549	16	and	and	CC
cord-285262-690kpupt	549	17	Ipaf	Ipaf	NNP
cord-285262-690kpupt	549	18	inflammasomes	inflammasome	VBZ
cord-285262-690kpupt	549	19	direct	direct	JJ
cord-285262-690kpupt	549	20	distinct	distinct	JJ
cord-285262-690kpupt	549	21	pathways	pathway	NNS
cord-285262-690kpupt	549	22	for	for	IN
cord-285262-690kpupt	549	23	caspase-1	caspase-1	NNP
cord-285262-690kpupt	549	24	activation	activation	NN
cord-285262-690kpupt	549	25	in	in	IN
cord-285262-690kpupt	549	26	response	response	NN
cord-285262-690kpupt	549	27	to	to	IN
cord-285262-690kpupt	549	28	Legionella	Legionella	NNP
cord-285262-690kpupt	549	29	pneumophila	pneumophila	NN
cord-285262-690kpupt	550	1	Caspase-11	Caspase-11	NNP
cord-285262-690kpupt	550	2	stimulates	stimulate	VBZ
cord-285262-690kpupt	550	3	rapid	rapid	JJ
cord-285262-690kpupt	550	4	flagellin	flagellin	JJ
cord-285262-690kpupt	550	5	-	-	HYPH
cord-285262-690kpupt	550	6	independent	independent	JJ
cord-285262-690kpupt	550	7	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	550	8	in	in	IN
cord-285262-690kpupt	550	9	response	response	NN
cord-285262-690kpupt	550	10	to	to	IN
cord-285262-690kpupt	550	11	Legionella	Legionella	NNP
cord-285262-690kpupt	550	12	pneumophila	pneumophila	NN
cord-285262-690kpupt	551	1	Intracytosolic	Intracytosolic	NNP
cord-285262-690kpupt	551	2	Listeria	Listeria	NNP
cord-285262-690kpupt	551	3	monocytogenes	monocytogenes	NN
cord-285262-690kpupt	551	4	induces	induce	VBZ
cord-285262-690kpupt	551	5	cell	cell	NN
cord-285262-690kpupt	551	6	death	death	NN
cord-285262-690kpupt	551	7	through	through	IN
cord-285262-690kpupt	551	8	caspase-1	caspase-1	NNP
cord-285262-690kpupt	551	9	activation	activation	NN
cord-285262-690kpupt	551	10	in	in	IN
cord-285262-690kpupt	551	11	murine	murine	JJ
cord-285262-690kpupt	551	12	macrophages	macrophage	NNS
cord-285262-690kpupt	551	13	Direct	direct	JJ
cord-285262-690kpupt	551	14	proteolytic	proteolytic	JJ
cord-285262-690kpupt	551	15	cleavage	cleavage	NN
cord-285262-690kpupt	551	16	of	of	IN
cord-285262-690kpupt	551	17	NLRP1B	nlrp1b	NN
cord-285262-690kpupt	551	18	is	be	VBZ
cord-285262-690kpupt	551	19	necessary	necessary	JJ
cord-285262-690kpupt	551	20	and	and	CC
cord-285262-690kpupt	551	21	sufficient	sufficient	JJ
cord-285262-690kpupt	551	22	for	for	IN
cord-285262-690kpupt	551	23	inflammasome	inflammasome	NN
cord-285262-690kpupt	551	24	activation	activation	NN
cord-285262-690kpupt	551	25	by	by	IN
cord-285262-690kpupt	551	26	anthrax	anthrax	NN
cord-285262-690kpupt	551	27	lethal	lethal	JJ
cord-285262-690kpupt	551	28	factor	factor	NN
cord-285262-690kpupt	552	1	A	a	DT
cord-285262-690kpupt	552	2	bacterial	bacterial	JJ
cord-285262-690kpupt	552	3	invasin	invasin	NNP
cord-285262-690kpupt	552	4	induces	induce	VBZ
cord-285262-690kpupt	552	5	macrophage	macrophage	NN
cord-285262-690kpupt	552	6	apoptosis	apoptosis	NN
cord-285262-690kpupt	552	7	by	by	IN
cord-285262-690kpupt	552	8	binding	bind	VBG
cord-285262-690kpupt	552	9	directly	directly	RB
cord-285262-690kpupt	552	10	to	to	IN
cord-285262-690kpupt	552	11	ICE	ice	NN
cord-285262-690kpupt	552	12	Proinflammatory	Proinflammatory	NNP
cord-285262-690kpupt	552	13	caspase-2-mediated	caspase-2-mediate	VBD
cord-285262-690kpupt	552	14	macrophage	macrophage	NN
cord-285262-690kpupt	552	15	cell	cell	NN
cord-285262-690kpupt	552	16	death	death	NN
cord-285262-690kpupt	552	17	induced	induce	VBN
cord-285262-690kpupt	552	18	by	by	IN
cord-285262-690kpupt	552	19	a	a	DT
cord-285262-690kpupt	552	20	rough	rough	JJ
cord-285262-690kpupt	552	21	attenuated	attenuate	VBN
cord-285262-690kpupt	552	22	Brucella	Brucella	NNP
cord-285262-690kpupt	552	23	suis	suis	NN
cord-285262-690kpupt	552	24	strain	strain	NN
cord-285262-690kpupt	552	25	Galectin-3	Galectin-3	NNP
cord-285262-690kpupt	552	26	enhances	enhance	VBZ
cord-285262-690kpupt	552	27	avian	avian	JJ
cord-285262-690kpupt	552	28	H5N1	H5N1	NNP
cord-285262-690kpupt	553	1	influenza	influenza	NN
cord-285262-690kpupt	553	2	A	a	DT
cord-285262-690kpupt	553	3	virusinduced	virusinduce	VBN
cord-285262-690kpupt	553	4	pulmonary	pulmonary	JJ
cord-285262-690kpupt	553	5	inflammation	inflammation	NN
cord-285262-690kpupt	553	6	by	by	IN
cord-285262-690kpupt	553	7	promoting	promote	VBG
cord-285262-690kpupt	553	8	NLRP3	NLRP3	NNP
cord-285262-690kpupt	553	9	inflammasome	inflammasome	NNP
cord-285262-690kpupt	553	10	activation	activation	NN
cord-285262-690kpupt	553	11	Involvement	Involvement	NNP
cord-285262-690kpupt	553	12	of	of	IN
cord-285262-690kpupt	553	13	caspase-4	caspase-4	NNP
cord-285262-690kpupt	553	14	in	in	IN
cord-285262-690kpupt	553	15	IL-1	IL-1	NNP
cord-285262-690kpupt	553	16	beta	beta	NN
cord-285262-690kpupt	553	17	production	production	NN
cord-285262-690kpupt	553	18	and	and	CC
cord-285262-690kpupt	553	19	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	553	20	in	in	IN
cord-285262-690kpupt	553	21	human	human	JJ
cord-285262-690kpupt	553	22	macrophages	macrophage	NNS
cord-285262-690kpupt	553	23	during	during	IN
cord-285262-690kpupt	553	24	dengue	dengue	NN
cord-285262-690kpupt	553	25	virus	virus	NN
cord-285262-690kpupt	553	26	infection	infection	NN
cord-285262-690kpupt	553	27	PRRs	prr	NNS
cord-285262-690kpupt	553	28	are	be	VBP
cord-285262-690kpupt	553	29	watching	watch	VBG
cord-285262-690kpupt	553	30	you	-PRON-	PRP
cord-285262-690kpupt	553	31	:	:	:
cord-285262-690kpupt	553	32	localization	localization	NN
cord-285262-690kpupt	553	33	of	of	IN
cord-285262-690kpupt	553	34	innate	innate	JJ
cord-285262-690kpupt	553	35	sensing	sensing	NN
cord-285262-690kpupt	553	36	and	and	CC
cord-285262-690kpupt	553	37	signaling	signal	VBG
cord-285262-690kpupt	553	38	regulators	regulator	NNS
cord-285262-690kpupt	554	1	Caspases	caspase	NNS
cord-285262-690kpupt	554	2	:	:	:
cord-285262-690kpupt	555	1	the	the	DT
cord-285262-690kpupt	555	2	executioners	executioner	NNS
cord-285262-690kpupt	555	3	of	of	IN
cord-285262-690kpupt	555	4	apoptosis	apoptosis	NN
cord-285262-690kpupt	555	5	Activation	Activation	NNP
cord-285262-690kpupt	555	6	of	of	IN
cord-285262-690kpupt	555	7	inflammasome	inflammasome	NN
cord-285262-690kpupt	555	8	signaling	signaling	NN
cord-285262-690kpupt	555	9	mediates	mediate	VBZ
cord-285262-690kpupt	555	10	pathology	pathology	NN
cord-285262-690kpupt	555	11	of	of	IN
cord-285262-690kpupt	555	12	acute	acute	JJ
cord-285262-690kpupt	555	13	P.	P.	NNP
cord-285262-690kpupt	555	14	aeruginosa	aeruginosa	NN
cord-285262-690kpupt	555	15	pneumonia	pneumonia	NN
cord-285262-690kpupt	555	16	AIM2	AIM2	NNP
cord-285262-690kpupt	555	17	senses	sense	VBZ
cord-285262-690kpupt	555	18	Brucella	Brucella	NNP
cord-285262-690kpupt	555	19	abortus	abortus	NN
cord-285262-690kpupt	555	20	DNA	dna	NN
cord-285262-690kpupt	555	21	in	in	IN
cord-285262-690kpupt	555	22	dendritic	dendritic	JJ
cord-285262-690kpupt	555	23	cells	cell	NNS
cord-285262-690kpupt	555	24	to	to	TO
cord-285262-690kpupt	555	25	induce	induce	VB
cord-285262-690kpupt	555	26	IL-1β	il-1β	JJ
cord-285262-690kpupt	555	27	secretion	secretion	NN
cord-285262-690kpupt	555	28	,	,	,
cord-285262-690kpupt	555	29	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	555	30	and	and	CC
cord-285262-690kpupt	555	31	resistance	resistance	NN
cord-285262-690kpupt	555	32	to	to	IN
cord-285262-690kpupt	555	33	bacterial	bacterial	JJ
cord-285262-690kpupt	555	34	infection	infection	NN
cord-285262-690kpupt	555	35	in	in	IN
cord-285262-690kpupt	555	36	mice	mouse	NNS
cord-285262-690kpupt	556	1	RNA	RNA	NNP
cord-285262-690kpupt	556	2	viruses	virus	NNS
cord-285262-690kpupt	556	3	promote	promote	VBP
cord-285262-690kpupt	556	4	activation	activation	NN
cord-285262-690kpupt	556	5	of	of	IN
cord-285262-690kpupt	556	6	the	the	DT
cord-285262-690kpupt	556	7	NLRP3	NLRP3	NNP
cord-285262-690kpupt	556	8	inflammasome	inflammasome	NNP
cord-285262-690kpupt	556	9	through	through	IN
cord-285262-690kpupt	556	10	cytopathogenic	cytopathogenic	JJ
cord-285262-690kpupt	556	11	effect	effect	NN
cord-285262-690kpupt	556	12	-	-	HYPH
cord-285262-690kpupt	556	13	induced	induce	VBN
cord-285262-690kpupt	556	14	potassium	potassium	NN
cord-285262-690kpupt	556	15	efflux	efflux	NN
cord-285262-690kpupt	557	1	situ	situ	NNP
cord-285262-690kpupt	557	2	inflammasome	inflammasome	NNP
cord-285262-690kpupt	557	3	activation	activation	NN
cord-285262-690kpupt	557	4	results	result	NNS
cord-285262-690kpupt	557	5	in	in	IN
cord-285262-690kpupt	557	6	severe	severe	JJ
cord-285262-690kpupt	557	7	damage	damage	NN
cord-285262-690kpupt	557	8	to	to	IN
cord-285262-690kpupt	557	9	the	the	DT
cord-285262-690kpupt	557	10	central	central	JJ
cord-285262-690kpupt	557	11	nervous	nervous	JJ
cord-285262-690kpupt	557	12	system	system	NN
cord-285262-690kpupt	557	13	in	in	IN
cord-285262-690kpupt	557	14	fatal	fatal	JJ
cord-285262-690kpupt	557	15	Zika	Zika	NNP
cord-285262-690kpupt	557	16	virus	virus	NN
cord-285262-690kpupt	557	17	microcephaly	microcephaly	NNS
cord-285262-690kpupt	557	18	cases	case	NNS
cord-285262-690kpupt	557	19	Chemical	Chemical	NNP
cord-285262-690kpupt	557	20	inhibitor	inhibitor	NN
cord-285262-690kpupt	557	21	of	of	IN
cord-285262-690kpupt	557	22	nonapoptotic	nonapoptotic	JJ
cord-285262-690kpupt	557	23	cell	cell	NN
cord-285262-690kpupt	557	24	death	death	NN
cord-285262-690kpupt	557	25	with	with	IN
cord-285262-690kpupt	557	26	therapeutic	therapeutic	JJ
cord-285262-690kpupt	557	27	potential	potential	NN
cord-285262-690kpupt	557	28	for	for	IN
cord-285262-690kpupt	557	29	ischemic	ischemic	JJ
cord-285262-690kpupt	557	30	brain	brain	NN
cord-285262-690kpupt	557	31	injury	injury	NN
cord-285262-690kpupt	557	32	Human	human	JJ
cord-285262-690kpupt	557	33	parvovirus	parvovirus	NN
cord-285262-690kpupt	557	34	infection	infection	NN
cord-285262-690kpupt	557	35	of	of	IN
cord-285262-690kpupt	557	36	human	human	JJ
cord-285262-690kpupt	557	37	airway	airway	NN
cord-285262-690kpupt	557	38	epithelia	epithelium	NNS
cord-285262-690kpupt	557	39	induces	induce	VBZ
cord-285262-690kpupt	557	40	pyroptotic	pyroptotic	JJ
cord-285262-690kpupt	557	41	cell	cell	NN
cord-285262-690kpupt	557	42	death	death	NN
cord-285262-690kpupt	557	43	by	by	IN
cord-285262-690kpupt	557	44	inhibiting	inhibit	VBG
cord-285262-690kpupt	557	45	apoptosis	apoptosis	NN
cord-285262-690kpupt	557	46	Viral	Viral	NNP
cord-285262-690kpupt	557	47	DNA	DNA	NNP
cord-285262-690kpupt	557	48	sensors	sensor	NNS
cord-285262-690kpupt	557	49	IFI16	ifi16	NN
cord-285262-690kpupt	557	50	and	and	CC
cord-285262-690kpupt	557	51	cyclic	cyclic	JJ
cord-285262-690kpupt	557	52	GMP	GMP	NNP
cord-285262-690kpupt	557	53	-	-	HYPH
cord-285262-690kpupt	557	54	AMP	AMP	NNP
cord-285262-690kpupt	557	55	synthase	synthase	NN
cord-285262-690kpupt	557	56	possess	possess	VBP
cord-285262-690kpupt	557	57	distinct	distinct	JJ
cord-285262-690kpupt	557	58	functions	function	NNS
cord-285262-690kpupt	557	59	in	in	IN
cord-285262-690kpupt	557	60	regulating	regulate	VBG
cord-285262-690kpupt	557	61	viral	viral	JJ
cord-285262-690kpupt	557	62	gene	gene	NN
cord-285262-690kpupt	557	63	expression	expression	NN
cord-285262-690kpupt	557	64	,	,	,
cord-285262-690kpupt	557	65	immune	immune	JJ
cord-285262-690kpupt	557	66	defenses	defense	NNS
cord-285262-690kpupt	557	67	,	,	,
cord-285262-690kpupt	557	68	and	and	CC
cord-285262-690kpupt	557	69	apoptotic	apoptotic	JJ
cord-285262-690kpupt	557	70	responses	response	NNS
cord-285262-690kpupt	557	71	during	during	IN
cord-285262-690kpupt	557	72	herpesvirus	herpesvirus	NN
cord-285262-690kpupt	557	73	infection	infection	NN
cord-285262-690kpupt	557	74	Cell	Cell	NNP
cord-285262-690kpupt	557	75	death	death	NN
cord-285262-690kpupt	557	76	by	by	IN
cord-285262-690kpupt	557	77	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	557	78	drives	drive	VBZ
cord-285262-690kpupt	557	79	CD4	CD4	NNP
cord-285262-690kpupt	557	80	T	T	NNP
cord-285262-690kpupt	557	81	-	-	HYPH
cord-285262-690kpupt	557	82	cell	cell	NN
cord-285262-690kpupt	557	83	depletion	depletion	NN
cord-285262-690kpupt	557	84	in	in	IN
cord-285262-690kpupt	557	85	HIV-1	HIV-1	NNP
cord-285262-690kpupt	557	86	infection	infection	NN
cord-285262-690kpupt	557	87	Serine	Serine	NNP
cord-285262-690kpupt	557	88	25	25	CD
cord-285262-690kpupt	557	89	phosphorylation	phosphorylation	NN
cord-285262-690kpupt	557	90	inhibits	inhibit	VBZ
cord-285262-690kpupt	557	91	RIPK1	ripk1	JJ
cord-285262-690kpupt	557	92	kinase	kinase	NN
cord-285262-690kpupt	557	93	-	-	HYPH
cord-285262-690kpupt	557	94	dependent	dependent	JJ
cord-285262-690kpupt	557	95	cell	cell	NN
cord-285262-690kpupt	557	96	death	death	NN
cord-285262-690kpupt	557	97	in	in	IN
cord-285262-690kpupt	557	98	models	model	NNS
cord-285262-690kpupt	557	99	of	of	IN
cord-285262-690kpupt	557	100	infection	infection	NN
cord-285262-690kpupt	557	101	and	and	CC
cord-285262-690kpupt	557	102	inflammation	inflammation	NN
cord-285262-690kpupt	557	103	MLKL	MLKL	NNP
cord-285262-690kpupt	557	104	requires	require	VBZ
cord-285262-690kpupt	557	105	the	the	DT
cord-285262-690kpupt	557	106	inositol	inositol	NN
cord-285262-690kpupt	557	107	phosphate	phosphate	NN
cord-285262-690kpupt	557	108	code	code	NN
cord-285262-690kpupt	557	109	to	to	TO
cord-285262-690kpupt	557	110	execute	execute	VB
cord-285262-690kpupt	557	111	necroptosis	necroptosis	NNP
cord-285262-690kpupt	558	1	The	the	DT
cord-285262-690kpupt	558	2	ribonucleotide	ribonucleotide	NN
cord-285262-690kpupt	558	3	reductase	reductase	NN
cord-285262-690kpupt	558	4	R1	r1	NN
cord-285262-690kpupt	558	5	subunits	subunit	NNS
cord-285262-690kpupt	558	6	of	of	IN
cord-285262-690kpupt	558	7	herpes	herpes	NN
cord-285262-690kpupt	558	8	simplex	simplex	NNP
cord-285262-690kpupt	558	9	virus	virus	NN
cord-285262-690kpupt	558	10	types	type	NNS
cord-285262-690kpupt	558	11	1	1	CD
cord-285262-690kpupt	558	12	and	and	CC
cord-285262-690kpupt	558	13	2	2	CD
cord-285262-690kpupt	558	14	protect	protect	VBP
cord-285262-690kpupt	558	15	cells	cell	NNS
cord-285262-690kpupt	558	16	against	against	IN
cord-285262-690kpupt	558	17	TNFα	TNFα	NNS
cord-285262-690kpupt	558	18	-	-	:
cord-285262-690kpupt	558	19	and	and	CC
cord-285262-690kpupt	558	20	FasL	FasL	NNP
cord-285262-690kpupt	558	21	-	-	HYPH
cord-285262-690kpupt	558	22	induced	induce	VBN
cord-285262-690kpupt	558	23	apoptosis	apoptosis	NN
cord-285262-690kpupt	558	24	by	by	IN
cord-285262-690kpupt	558	25	interacting	interact	VBG
cord-285262-690kpupt	558	26	with	with	IN
cord-285262-690kpupt	558	27	caspase-8	caspase-8	NNP
cord-285262-690kpupt	558	28	A	a	DT
cord-285262-690kpupt	558	29	papillomavirus	papillomavirus	NN
cord-285262-690kpupt	558	30	DNA	dna	NN
cord-285262-690kpupt	558	31	from	from	IN
cord-285262-690kpupt	558	32	a	a	DT
cord-285262-690kpupt	558	33	cervical	cervical	JJ
cord-285262-690kpupt	558	34	carcinoma	carcinoma	NN
cord-285262-690kpupt	558	35	and	and	CC
cord-285262-690kpupt	558	36	its	-PRON-	PRP$
cord-285262-690kpupt	558	37	prevalence	prevalence	NN
cord-285262-690kpupt	558	38	in	in	IN
cord-285262-690kpupt	558	39	cancer	cancer	NN
cord-285262-690kpupt	558	40	biopsy	biopsy	NN
cord-285262-690kpupt	558	41	samples	sample	NNS
cord-285262-690kpupt	558	42	from	from	IN
cord-285262-690kpupt	558	43	different	different	JJ
cord-285262-690kpupt	558	44	geographic	geographic	JJ
cord-285262-690kpupt	558	45	regions	region	NNS
cord-285262-690kpupt	558	46	Block	Block	NNP
cord-285262-690kpupt	558	47	of	of	IN
cord-285262-690kpupt	558	48	death	death	NN
cord-285262-690kpupt	558	49	-	-	HYPH
cord-285262-690kpupt	558	50	receptor	receptor	NN
cord-285262-690kpupt	558	51	apoptosis	apoptosis	NN
cord-285262-690kpupt	558	52	protects	protect	VBZ
cord-285262-690kpupt	558	53	mouse	mouse	NN
cord-285262-690kpupt	558	54	cytomegalovirus	cytomegalovirus	NN
cord-285262-690kpupt	558	55	from	from	IN
cord-285262-690kpupt	558	56	macrophages	macrophage	NNS
cord-285262-690kpupt	558	57	and	and	CC
cord-285262-690kpupt	558	58	is	be	VBZ
cord-285262-690kpupt	558	59	a	a	DT
cord-285262-690kpupt	558	60	determinant	determinant	NN
cord-285262-690kpupt	558	61	of	of	IN
cord-285262-690kpupt	558	62	virulence	virulence	NN
cord-285262-690kpupt	558	63	in	in	IN
cord-285262-690kpupt	558	64	immunodeficient	immunodeficient	JJ
cord-285262-690kpupt	558	65	hosts	host	NNS
cord-285262-690kpupt	558	66	Induction	Induction	NNP
cord-285262-690kpupt	558	67	of	of	IN
cord-285262-690kpupt	558	68	Noxa	Noxa	NNP
cord-285262-690kpupt	558	69	-	-	HYPH
cord-285262-690kpupt	558	70	mediated	mediate	VBN
cord-285262-690kpupt	558	71	apoptosis	apoptosis	NN
cord-285262-690kpupt	558	72	by	by	IN
cord-285262-690kpupt	559	1	modified	modify	VBN
cord-285262-690kpupt	559	2	vaccinia	vaccinia	NN
cord-285262-690kpupt	559	3	virus	virus	NN
cord-285262-690kpupt	559	4	Ankara	Ankara	NNP
cord-285262-690kpupt	559	5	depends	depend	VBZ
cord-285262-690kpupt	559	6	on	on	IN
cord-285262-690kpupt	559	7	viral	viral	JJ
cord-285262-690kpupt	559	8	recognition	recognition	NN
cord-285262-690kpupt	559	9	by	by	IN
cord-285262-690kpupt	559	10	cytosolic	cytosolic	JJ
cord-285262-690kpupt	559	11	helicases	helicase	NNS
cord-285262-690kpupt	559	12	,	,	,
cord-285262-690kpupt	559	13	leading	lead	VBG
cord-285262-690kpupt	559	14	to	to	IN
cord-285262-690kpupt	559	15	IRF-3	IRF-3	NNP
cord-285262-690kpupt	559	16	/	/	SYM
cord-285262-690kpupt	559	17	IFN	IFN	NNP
cord-285262-690kpupt	559	18	-	-	HYPH
cord-285262-690kpupt	559	19	β	β	NN
cord-285262-690kpupt	559	20	-	-	HYPH
cord-285262-690kpupt	559	21	dependent	dependent	JJ
cord-285262-690kpupt	559	22	induction	induction	NN
cord-285262-690kpupt	559	23	of	of	IN
cord-285262-690kpupt	559	24	proapoptotic	proapoptotic	JJ
cord-285262-690kpupt	559	25	Noxa	Noxa	NNP
cord-285262-690kpupt	560	1	A	a	DT
cord-285262-690kpupt	560	2	novel	novel	NN
cord-285262-690kpupt	560	3	mitochondrial	mitochondrial	NN
cord-285262-690kpupt	560	4	MAVS	MAVS	NNP
cord-285262-690kpupt	560	5	/	/	SYM
cord-285262-690kpupt	560	6	Caspase-8	Caspase-8	NNP
cord-285262-690kpupt	561	1	platform	platform	NNP
cord-285262-690kpupt	561	2	links	link	VBZ
cord-285262-690kpupt	561	3	RNA	RNA	NNP
cord-285262-690kpupt	561	4	virus	virus	NN
cord-285262-690kpupt	561	5	-	-	HYPH
cord-285262-690kpupt	561	6	induced	induce	VBN
cord-285262-690kpupt	561	7	innate	innate	JJ
cord-285262-690kpupt	561	8	antiviral	antiviral	JJ
cord-285262-690kpupt	561	9	signaling	signal	VBG
cord-285262-690kpupt	561	10	to	to	IN
cord-285262-690kpupt	561	11	Bax	Bax	NNP
cord-285262-690kpupt	561	12	/	/	SYM
cord-285262-690kpupt	561	13	Bak	Bak	NNP
cord-285262-690kpupt	561	14	-	-	HYPH
cord-285262-690kpupt	561	15	independent	independent	JJ
cord-285262-690kpupt	561	16	apoptosis	apoptosis	NN
cord-285262-690kpupt	562	1	The	the	DT
cord-285262-690kpupt	562	2	pore	pore	NN
cord-285262-690kpupt	562	3	-	-	HYPH
cord-285262-690kpupt	562	4	forming	form	VBG
cord-285262-690kpupt	562	5	protein	protein	NN
cord-285262-690kpupt	562	6	gasdermin	gasdermin	NNP
cord-285262-690kpupt	562	7	D	D	NNP
cord-285262-690kpupt	562	8	regulates	regulate	VBZ
cord-285262-690kpupt	562	9	interleukin-1	interleukin-1	NN
cord-285262-690kpupt	562	10	secretion	secretion	NN
cord-285262-690kpupt	562	11	from	from	IN
cord-285262-690kpupt	562	12	living	live	VBG
cord-285262-690kpupt	562	13	macrophages	macrophage	NNS
cord-285262-690kpupt	562	14	Exposure	exposure	NN
cord-285262-690kpupt	562	15	of	of	IN
cord-285262-690kpupt	562	16	phosphatidylserine	phosphatidylserine	NN
cord-285262-690kpupt	562	17	on	on	IN
cord-285262-690kpupt	562	18	the	the	DT
cord-285262-690kpupt	562	19	surface	surface	NN
cord-285262-690kpupt	562	20	of	of	IN
cord-285262-690kpupt	562	21	apoptotic	apoptotic	JJ
cord-285262-690kpupt	562	22	lymphocytes	lymphocyte	NNS
cord-285262-690kpupt	563	1	triggers	trigger	VBZ
cord-285262-690kpupt	563	2	specific	specific	JJ
cord-285262-690kpupt	563	3	recognition	recognition	NN
cord-285262-690kpupt	563	4	and	and	CC
cord-285262-690kpupt	563	5	removal	removal	NN
cord-285262-690kpupt	563	6	by	by	IN
cord-285262-690kpupt	563	7	macrophages	macrophage	NNS
cord-285262-690kpupt	563	8	cIAPs	ciaps	ADD
cord-285262-690kpupt	563	9	block	block	NN
cord-285262-690kpupt	563	10	Ripoptosome	Ripoptosome	NNP
cord-285262-690kpupt	563	11	formation	formation	NN
cord-285262-690kpupt	563	12	,	,	,
cord-285262-690kpupt	563	13	a	a	DT
cord-285262-690kpupt	563	14	RIP1	RIP1	NNP
cord-285262-690kpupt	563	15	/	/	SYM
cord-285262-690kpupt	563	16	caspase-8	caspase-8	NNP
cord-285262-690kpupt	563	17	containing	contain	VBG
cord-285262-690kpupt	563	18	intracellular	intracellular	JJ
cord-285262-690kpupt	563	19	cell	cell	NN
cord-285262-690kpupt	563	20	death	death	NN
cord-285262-690kpupt	563	21	complex	complex	NN
cord-285262-690kpupt	563	22	differentially	differentially	RB
cord-285262-690kpupt	563	23	regulated	regulate	VBN
cord-285262-690kpupt	563	24	by	by	IN
cord-285262-690kpupt	563	25	cFLIP	cFLIP	NNP
cord-285262-690kpupt	563	26	isoforms	isoform	NNS
cord-285262-690kpupt	564	1	Ion	ion	NN
cord-285262-690kpupt	564	2	efflux	efflux	NN
cord-285262-690kpupt	564	3	and	and	CC
cord-285262-690kpupt	564	4	influenza	influenza	NN
cord-285262-690kpupt	564	5	infection	infection	NN
cord-285262-690kpupt	564	6	trigger	trigger	NN
cord-285262-690kpupt	564	7	NLRP3	nlrp3	XX
cord-285262-690kpupt	564	8	inflammasome	inflammasome	NNP
cord-285262-690kpupt	564	9	signaling	signal	VBG
cord-285262-690kpupt	564	10	in	in	IN
cord-285262-690kpupt	564	11	human	human	JJ
cord-285262-690kpupt	564	12	dendritic	dendritic	JJ
cord-285262-690kpupt	564	13	cells	cell	NNS
cord-285262-690kpupt	565	1	Guanylate	guanylate	JJ
cord-285262-690kpupt	565	2	binding	binding	NN
cord-285262-690kpupt	565	3	proteins	protein	NNS
cord-285262-690kpupt	565	4	enable	enable	VBP
cord-285262-690kpupt	565	5	rapid	rapid	JJ
cord-285262-690kpupt	565	6	activation	activation	NN
cord-285262-690kpupt	565	7	of	of	IN
cord-285262-690kpupt	565	8	canonical	canonical	JJ
cord-285262-690kpupt	565	9	and	and	CC
cord-285262-690kpupt	565	10	noncanonical	noncanonical	JJ
cord-285262-690kpupt	565	11	inflammasomes	inflammasome	NNS
cord-285262-690kpupt	565	12	in	in	IN
cord-285262-690kpupt	565	13	Chlamydia	Chlamydia	NNP
cord-285262-690kpupt	565	14	-	-	HYPH
cord-285262-690kpupt	565	15	infected	infect	VBN
cord-285262-690kpupt	565	16	macrophages	macrophage	NNS
cord-285262-690kpupt	565	17	Caspase-1-dependent	Caspase-1-dependent	NNP
cord-285262-690kpupt	565	18	pore	pore	NN
cord-285262-690kpupt	565	19	formation	formation	NN
cord-285262-690kpupt	565	20	during	during	IN
cord-285262-690kpupt	565	21	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	565	22	leads	lead	VBZ
cord-285262-690kpupt	565	23	to	to	IN
cord-285262-690kpupt	565	24	osmotic	osmotic	JJ
cord-285262-690kpupt	565	25	lysis	lysis	NN
cord-285262-690kpupt	565	26	of	of	IN
cord-285262-690kpupt	565	27	infected	infected	JJ
cord-285262-690kpupt	565	28	host	host	NN
cord-285262-690kpupt	565	29	macrophages	macrophage	VBZ
cord-285262-690kpupt	565	30	Anthrax	Anthrax	NNP
cord-285262-690kpupt	565	31	lethal	lethal	JJ
cord-285262-690kpupt	565	32	toxin	toxin	NN
cord-285262-690kpupt	565	33	and	and	CC
cord-285262-690kpupt	565	34	Salmonella	Salmonella	NNP
cord-285262-690kpupt	565	35	elicit	elicit	VBP
cord-285262-690kpupt	565	36	the	the	DT
cord-285262-690kpupt	565	37	common	common	JJ
cord-285262-690kpupt	565	38	cell	cell	NN
cord-285262-690kpupt	565	39	death	death	NN
cord-285262-690kpupt	565	40	pathway	pathway	NN
cord-285262-690kpupt	565	41	of	of	IN
cord-285262-690kpupt	565	42	caspase-1-dependent	caspase-1-dependent	NNP
cord-285262-690kpupt	565	43	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	565	44	via	via	IN
cord-285262-690kpupt	565	45	distinct	distinct	JJ
cord-285262-690kpupt	565	46	mechanisms	mechanism	NNS
cord-285262-690kpupt	566	1	IKKepsilon	IKKepsilon	NNP
cord-285262-690kpupt	566	2	and	and	CC
cord-285262-690kpupt	566	3	TBK1	TBK1	NNP
cord-285262-690kpupt	566	4	are	be	VBP
cord-285262-690kpupt	566	5	essential	essential	JJ
cord-285262-690kpupt	566	6	components	component	NNS
cord-285262-690kpupt	566	7	of	of	IN
cord-285262-690kpupt	566	8	the	the	DT
cord-285262-690kpupt	566	9	IRF3	IRF3	NNP
cord-285262-690kpupt	566	10	signaling	signal	VBG
cord-285262-690kpupt	566	11	pathway	pathway	NN
cord-285262-690kpupt	566	12	The	the	DT
cord-285262-690kpupt	566	13	NS1	ns1	NN
cord-285262-690kpupt	566	14	protein	protein	NN
cord-285262-690kpupt	566	15	of	of	IN
cord-285262-690kpupt	566	16	influenza	influenza	NN
cord-285262-690kpupt	566	17	A	a	DT
cord-285262-690kpupt	566	18	virus	virus	NN
cord-285262-690kpupt	566	19	participates	participate	VBZ
cord-285262-690kpupt	566	20	in	in	IN
cord-285262-690kpupt	566	21	necroptosis	necroptosis	NNP
cord-285262-690kpupt	566	22	by	by	IN
cord-285262-690kpupt	566	23	interacting	interact	VBG
cord-285262-690kpupt	566	24	with	with	IN
cord-285262-690kpupt	566	25	MLKL	MLKL	NNP
cord-285262-690kpupt	566	26	and	and	CC
cord-285262-690kpupt	566	27	increasing	increase	VBG
cord-285262-690kpupt	566	28	its	-PRON-	PRP$
cord-285262-690kpupt	566	29	oligomerization	oligomerization	NN
cord-285262-690kpupt	566	30	and	and	CC
cord-285262-690kpupt	566	31	membrane	membrane	NN
cord-285262-690kpupt	566	32	translocation	translocation	NN
cord-285262-690kpupt	566	33	Cell	cell	NN
cord-285262-690kpupt	566	34	-	-	HYPH
cord-285262-690kpupt	566	35	to	to	IN
cord-285262-690kpupt	566	36	-	-	HYPH
cord-285262-690kpupt	566	37	cell	cell	NN
cord-285262-690kpupt	566	38	transmission	transmission	NN
cord-285262-690kpupt	566	39	of	of	IN
cord-285262-690kpupt	566	40	HIV-1	HIV-1	NNP
cord-285262-690kpupt	566	41	is	be	VBZ
cord-285262-690kpupt	566	42	required	require	VBN
cord-285262-690kpupt	566	43	to	to	TO
cord-285262-690kpupt	566	44	trigger	trigger	VB
cord-285262-690kpupt	566	45	pyroptotic	pyroptotic	JJ
cord-285262-690kpupt	566	46	death	death	NN
cord-285262-690kpupt	566	47	of	of	IN
cord-285262-690kpupt	566	48	lymphoid	lymphoid	JJ
cord-285262-690kpupt	566	49	-	-	HYPH
cord-285262-690kpupt	566	50	tissue	tissue	NN
cord-285262-690kpupt	566	51	-	-	HYPH
cord-285262-690kpupt	566	52	derived	derive	VBN
cord-285262-690kpupt	566	53	CD4	CD4	NNP
cord-285262-690kpupt	566	54	T	T	NNP
cord-285262-690kpupt	566	55	cells	cell	NNS
cord-285262-690kpupt	566	56	Pore	pore	NN
cord-285262-690kpupt	566	57	-	-	HYPH
cord-285262-690kpupt	566	58	forming	form	VBG
cord-285262-690kpupt	566	59	toxin	toxin	NN
cord-285262-690kpupt	566	60	-	-	HYPH
cord-285262-690kpupt	566	61	mediated	mediate	VBN
cord-285262-690kpupt	566	62	ion	ion	NN
cord-285262-690kpupt	566	63	dysregulation	dysregulation	NN
cord-285262-690kpupt	566	64	leads	lead	VBZ
cord-285262-690kpupt	566	65	to	to	IN
cord-285262-690kpupt	566	66	death	death	NN
cord-285262-690kpupt	566	67	receptor	receptor	NN
cord-285262-690kpupt	566	68	-	-	HYPH
cord-285262-690kpupt	566	69	independent	independent	JJ
cord-285262-690kpupt	566	70	necroptosis	necroptosis	NN
cord-285262-690kpupt	566	71	of	of	IN
cord-285262-690kpupt	566	72	lung	lung	NN
cord-285262-690kpupt	566	73	epithelial	epithelial	JJ
cord-285262-690kpupt	566	74	cells	cell	NNS
cord-285262-690kpupt	566	75	during	during	IN
cord-285262-690kpupt	566	76	bacterial	bacterial	JJ
cord-285262-690kpupt	566	77	pneumonia	pneumonia	NN
cord-285262-690kpupt	566	78	Bacterial	bacterial	JJ
cord-285262-690kpupt	566	79	pore	pore	NN
cord-285262-690kpupt	566	80	-	-	HYPH
cord-285262-690kpupt	566	81	forming	form	VBG
cord-285262-690kpupt	566	82	toxins	toxin	NNS
cord-285262-690kpupt	566	83	promote	promote	VBP
cord-285262-690kpupt	566	84	the	the	DT
cord-285262-690kpupt	566	85	activation	activation	NN
cord-285262-690kpupt	566	86	of	of	IN
cord-285262-690kpupt	566	87	caspases	caspase	NNS
cord-285262-690kpupt	566	88	in	in	IN
cord-285262-690kpupt	566	89	parallel	parallel	NN
cord-285262-690kpupt	566	90	to	to	IN
cord-285262-690kpupt	566	91	necroptosis	necroptosis	NN
cord-285262-690kpupt	566	92	to	to	TO
cord-285262-690kpupt	566	93	enhance	enhance	VB
cord-285262-690kpupt	566	94	alarmin	alarmin	NNP
cord-285262-690kpupt	566	95	release	release	NN
cord-285262-690kpupt	566	96	and	and	CC
cord-285262-690kpupt	566	97	inflammation	inflammation	NN
cord-285262-690kpupt	566	98	during	during	IN
cord-285262-690kpupt	566	99	pneumonia	pneumonia	NN
cord-285262-690kpupt	566	100	Absence	absence	NN
cord-285262-690kpupt	566	101	of	of	IN
cord-285262-690kpupt	566	102	Toll	Toll	NNP
cord-285262-690kpupt	566	103	-	-	HYPH
cord-285262-690kpupt	566	104	like	like	JJ
cord-285262-690kpupt	566	105	receptor	receptor	NN
cord-285262-690kpupt	566	106	4	4	CD
cord-285262-690kpupt	566	107	signaling	signal	VBG
cord-285262-690kpupt	566	108	results	result	NNS
cord-285262-690kpupt	566	109	in	in	IN
cord-285262-690kpupt	566	110	delayed	delay	VBN
cord-285262-690kpupt	566	111	Yersinia	Yersinia	NNP
cord-285262-690kpupt	566	112	enterocolitica	enterocolitica	NNP
cord-285262-690kpupt	566	113	YopP	YopP	NNP
cord-285262-690kpupt	566	114	-	-	HYPH
cord-285262-690kpupt	566	115	induced	induce	VBN
cord-285262-690kpupt	566	116	cell	cell	NN
cord-285262-690kpupt	566	117	death	death	NN
cord-285262-690kpupt	566	118	of	of	IN
cord-285262-690kpupt	566	119	dendritic	dendritic	JJ
cord-285262-690kpupt	566	120	cells	cell	NNS
cord-285262-690kpupt	566	121	Bax	Bax	NNP
cord-285262-690kpupt	566	122	assembles	assemble	VBZ
cord-285262-690kpupt	566	123	into	into	IN
cord-285262-690kpupt	566	124	large	large	JJ
cord-285262-690kpupt	566	125	ring	ring	NN
cord-285262-690kpupt	566	126	-	-	HYPH
cord-285262-690kpupt	566	127	like	like	JJ
cord-285262-690kpupt	566	128	structures	structure	NNS
cord-285262-690kpupt	566	129	remodeling	remodel	VBG
cord-285262-690kpupt	566	130	the	the	DT
cord-285262-690kpupt	566	131	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	566	132	outer	outer	JJ
cord-285262-690kpupt	566	133	membrane	membrane	NN
cord-285262-690kpupt	566	134	in	in	IN
cord-285262-690kpupt	566	135	apoptosis	apoptosis	NN
cord-285262-690kpupt	566	136	Herpes	Herpes	NNP
cord-285262-690kpupt	566	137	simplex	simplex	NN
cord-285262-690kpupt	566	138	virus	virus	NN
cord-285262-690kpupt	567	1	suppresses	suppress	VBZ
cord-285262-690kpupt	567	2	necroptosis	necroptosis	NNP
cord-285262-690kpupt	567	3	in	in	IN
cord-285262-690kpupt	567	4	human	human	JJ
cord-285262-690kpupt	567	5	cells	cell	NNS
cord-285262-690kpupt	567	6	Species	species	NN
cord-285262-690kpupt	567	7	-	-	HYPH
cord-285262-690kpupt	567	8	independent	independent	JJ
cord-285262-690kpupt	567	9	contribution	contribution	NN
cord-285262-690kpupt	567	10	of	of	IN
cord-285262-690kpupt	567	11	ZBP1	ZBP1	NNP
cord-285262-690kpupt	567	12	/	/	SYM
cord-285262-690kpupt	567	13	DAI	DAI	NNP
cord-285262-690kpupt	567	14	/	/	SYM
cord-285262-690kpupt	567	15	DLM-1-triggered	dlm-1-triggere	VBN
cord-285262-690kpupt	567	16	necroptosis	necroptosis	NNP
cord-285262-690kpupt	567	17	in	in	IN
cord-285262-690kpupt	567	18	host	host	NN
cord-285262-690kpupt	567	19	defense	defense	NN
cord-285262-690kpupt	567	20	against	against	IN
cord-285262-690kpupt	567	21	HSV1	HSV1	NNP
cord-285262-690kpupt	567	22	Mechanisms	Mechanisms	NNPS
cord-285262-690kpupt	567	23	and	and	CC
cord-285262-690kpupt	567	24	dynamics	dynamic	NNS
cord-285262-690kpupt	567	25	of	of	IN
cord-285262-690kpupt	567	26	T	T	NNP
cord-285262-690kpupt	567	27	cell	cell	NN
cord-285262-690kpupt	567	28	-	-	HYPH
cord-285262-690kpupt	567	29	mediated	mediate	VBN
cord-285262-690kpupt	567	30	cytotoxicity	cytotoxicity	NN
cord-285262-690kpupt	567	31	in	in	IN
cord-285262-690kpupt	567	32	vivo	vivo	NN
cord-285262-690kpupt	568	1	Enterovirus	enterovirus	NN
cord-285262-690kpupt	568	2	71	71	CD
cord-285262-690kpupt	568	3	induces	induce	VBZ
cord-285262-690kpupt	568	4	apoptosis	apoptosis	NN
cord-285262-690kpupt	568	5	by	by	IN
cord-285262-690kpupt	568	6	directly	directly	RB
cord-285262-690kpupt	568	7	modulating	modulate	VBG
cord-285262-690kpupt	568	8	the	the	DT
cord-285262-690kpupt	568	9	conformational	conformational	JJ
cord-285262-690kpupt	568	10	activation	activation	NN
cord-285262-690kpupt	568	11	of	of	IN
cord-285262-690kpupt	568	12	pro	pro	JJ
cord-285262-690kpupt	568	13	-	-	JJ
cord-285262-690kpupt	568	14	apoptotic	apoptotic	JJ
cord-285262-690kpupt	568	15	protein	protein	NN
cord-285262-690kpupt	569	1	Bax	Bax	NNP
cord-285262-690kpupt	569	2	Toll	Toll	NNP
cord-285262-690kpupt	569	3	-	-	HYPH
cord-285262-690kpupt	569	4	like	like	JJ
cord-285262-690kpupt	569	5	receptors	receptor	NNS
cord-285262-690kpupt	569	6	activate	activate	VBP
cord-285262-690kpupt	569	7	programmed	program	VBN
cord-285262-690kpupt	569	8	necrosis	necrosis	NN
cord-285262-690kpupt	569	9	in	in	IN
cord-285262-690kpupt	569	10	macrophages	macrophage	NNS
cord-285262-690kpupt	569	11	through	through	IN
cord-285262-690kpupt	569	12	a	a	DT
cord-285262-690kpupt	569	13	receptor	receptor	NN
cord-285262-690kpupt	569	14	-	-	HYPH
cord-285262-690kpupt	569	15	interacting	interact	VBG
cord-285262-690kpupt	569	16	kinase-3-mediated	kinase-3-mediated	JJ
cord-285262-690kpupt	569	17	pathway	pathway	NN
cord-285262-690kpupt	569	18	Gasdermin	Gasdermin	NNP
cord-285262-690kpupt	569	19	D	D	NNP
cord-285262-690kpupt	569	20	is	be	VBZ
cord-285262-690kpupt	569	21	an	an	DT
cord-285262-690kpupt	569	22	executor	executor	NN
cord-285262-690kpupt	569	23	of	of	IN
cord-285262-690kpupt	569	24	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	569	25	and	and	CC
cord-285262-690kpupt	569	26	required	require	VBN
cord-285262-690kpupt	569	27	for	for	IN
cord-285262-690kpupt	569	28	interleukin-1β	interleukin-1β	NNP
cord-285262-690kpupt	569	29	secretion	secretion	NN
cord-285262-690kpupt	569	30	Induction	Induction	NNP
cord-285262-690kpupt	569	31	of	of	IN
cord-285262-690kpupt	569	32	bcl-2	bcl-2	NNP
cord-285262-690kpupt	569	33	expression	expression	NN
cord-285262-690kpupt	569	34	by	by	IN
cord-285262-690kpupt	569	35	epstein	epstein	NNP
cord-285262-690kpupt	569	36	-	-	HYPH
cord-285262-690kpupt	569	37	barr	barr	NNP
cord-285262-690kpupt	569	38	virus	virus	NN
cord-285262-690kpupt	569	39	latent	latent	NNP
cord-285262-690kpupt	569	40	membrane	membrane	NN
cord-285262-690kpupt	569	41	protein	protein	NN
cord-285262-690kpupt	569	42	1	1	CD
cord-285262-690kpupt	570	1	protects	protect	VBZ
cord-285262-690kpupt	570	2	infected	infect	VBN
cord-285262-690kpupt	570	3	B	B	NNP
cord-285262-690kpupt	570	4	cells	cell	NNS
cord-285262-690kpupt	570	5	from	from	IN
cord-285262-690kpupt	570	6	programmed	programmed	JJ
cord-285262-690kpupt	570	7	cell	cell	NN
cord-285262-690kpupt	570	8	death	death	NN
cord-285262-690kpupt	570	9	TNF	TNF	NNP
cord-285262-690kpupt	570	10	-	-	HYPH
cord-285262-690kpupt	570	11	dependent	dependent	JJ
cord-285262-690kpupt	570	12	recruitment	recruitment	NN
cord-285262-690kpupt	570	13	of	of	IN
cord-285262-690kpupt	570	14	the	the	DT
cord-285262-690kpupt	570	15	protein	protein	NN
cord-285262-690kpupt	570	16	kinase	kinase	NN
cord-285262-690kpupt	570	17	RIP	RIP	NNP
cord-285262-690kpupt	570	18	to	to	IN
cord-285262-690kpupt	570	19	the	the	DT
cord-285262-690kpupt	570	20	TNF	TNF	NNP
cord-285262-690kpupt	570	21	receptor-1	receptor-1	NNP
cord-285262-690kpupt	570	22	signaling	signal	VBG
cord-285262-690kpupt	570	23	complex	complex	JJ
cord-285262-690kpupt	570	24	Salmonella	Salmonella	NNP
cord-285262-690kpupt	570	25	outer	outer	JJ
cord-285262-690kpupt	570	26	protein	protein	NN
cord-285262-690kpupt	570	27	b	b	NNP
cord-285262-690kpupt	570	28	suppresses	suppress	VBZ
cord-285262-690kpupt	570	29	colitis	colitis	NN
cord-285262-690kpupt	570	30	development	development	NN
cord-285262-690kpupt	570	31	via	via	IN
cord-285262-690kpupt	570	32	protecting	protect	VBG
cord-285262-690kpupt	570	33	cell	cell	NN
cord-285262-690kpupt	570	34	from	from	IN
cord-285262-690kpupt	570	35	necroptosis	necroptosis	NNP
cord-285262-690kpupt	570	36	RIP1	RIP1	NNP
cord-285262-690kpupt	570	37	/	/	SYM
cord-285262-690kpupt	570	38	RIP3	RIP3	NNPS
cord-285262-690kpupt	570	39	binding	bind	VBG
cord-285262-690kpupt	570	40	to	to	IN
cord-285262-690kpupt	570	41	HSV-1	HSV-1	NNP
cord-285262-690kpupt	570	42	ICP6	ICP6	NNP
cord-285262-690kpupt	571	1	initiates	initiate	VBZ
cord-285262-690kpupt	571	2	necroptosis	necroptosis	NNP
cord-285262-690kpupt	571	3	to	to	TO
cord-285262-690kpupt	571	4	restrict	restrict	VB
cord-285262-690kpupt	571	5	virus	virus	NN
cord-285262-690kpupt	571	6	propagation	propagation	NN
cord-285262-690kpupt	571	7	in	in	IN
cord-285262-690kpupt	571	8	mice	mouse	NNS
cord-285262-690kpupt	572	1	The	the	DT
cord-285262-690kpupt	572	2	E3	e3	NN
cord-285262-690kpupt	572	3	ubiquitin	ubiquitin	NN
cord-285262-690kpupt	572	4	ligase	ligase	NN
cord-285262-690kpupt	572	5	Pellino2	Pellino2	NNP
cord-285262-690kpupt	572	6	mediates	mediate	VBZ
cord-285262-690kpupt	572	7	priming	priming	NN
cord-285262-690kpupt	572	8	of	of	IN
cord-285262-690kpupt	572	9	the	the	DT
cord-285262-690kpupt	572	10	NLRP3	NLRP3	NNP
cord-285262-690kpupt	572	11	inflammasome	inflammasome	NNP
cord-285262-690kpupt	572	12	Caspase-2	Caspase-2	NNP
cord-285262-690kpupt	573	1	is	be	VBZ
cord-285262-690kpupt	573	2	an	an	DT
cord-285262-690kpupt	573	3	initiator	initiator	NN
cord-285262-690kpupt	573	4	caspase	caspase	NN
cord-285262-690kpupt	573	5	responsible	responsible	JJ
cord-285262-690kpupt	573	6	for	for	IN
cord-285262-690kpupt	573	7	pore	pore	NN
cord-285262-690kpupt	573	8	-	-	HYPH
cord-285262-690kpupt	573	9	forming	form	VBG
cord-285262-690kpupt	573	10	toxin	toxin	NN
cord-285262-690kpupt	573	11	-	-	HYPH
cord-285262-690kpupt	573	12	mediated	mediate	VBN
cord-285262-690kpupt	573	13	apoptosis	apoptosis	NN
cord-285262-690kpupt	573	14	STING	sting	NN
cord-285262-690kpupt	573	15	is	be	VBZ
cord-285262-690kpupt	573	16	an	an	DT
cord-285262-690kpupt	573	17	endoplasmic	endoplasmic	NN
cord-285262-690kpupt	573	18	reticulum	reticulum	NN
cord-285262-690kpupt	573	19	adaptor	adaptor	NN
cord-285262-690kpupt	573	20	that	that	WDT
cord-285262-690kpupt	573	21	facilitates	facilitate	VBZ
cord-285262-690kpupt	573	22	innate	innate	JJ
cord-285262-690kpupt	573	23	immune	immune	JJ
cord-285262-690kpupt	573	24	signalling	signal	VBG
cord-285262-690kpupt	573	25	Programmed	program	VBN
cord-285262-690kpupt	573	26	cell	cell	NN
cord-285262-690kpupt	573	27	death	death	NN
cord-285262-690kpupt	573	28	as	as	IN
cord-285262-690kpupt	573	29	a	a	DT
cord-285262-690kpupt	573	30	defence	defence	NN
cord-285262-690kpupt	573	31	against	against	IN
cord-285262-690kpupt	573	32	infection	infection	NN
cord-285262-690kpupt	573	33	Caspase-1	Caspase-1	NNP
cord-285262-690kpupt	573	34	activity	activity	NN
cord-285262-690kpupt	573	35	affects	affect	VBZ
cord-285262-690kpupt	573	36	AIM2	AIM2	NNP
cord-285262-690kpupt	573	37	speck	speck	NN
cord-285262-690kpupt	573	38	formation	formation	NN
cord-285262-690kpupt	573	39	/	/	SYM
cord-285262-690kpupt	573	40	stability	stability	NN
cord-285262-690kpupt	573	41	through	through	IN
cord-285262-690kpupt	573	42	a	a	DT
cord-285262-690kpupt	573	43	negative	negative	JJ
cord-285262-690kpupt	573	44	feedback	feedback	NN
cord-285262-690kpupt	573	45	loop	loop	NN
cord-285262-690kpupt	573	46	Apoptosis	apoptosis	NN
cord-285262-690kpupt	573	47	induced	induce	VBN
cord-285262-690kpupt	573	48	by	by	IN
cord-285262-690kpupt	573	49	the	the	DT
cord-285262-690kpupt	573	50	Toll	Toll	NNP
cord-285262-690kpupt	573	51	-	-	HYPH
cord-285262-690kpupt	573	52	like	like	JJ
cord-285262-690kpupt	573	53	receptor	receptor	NN
cord-285262-690kpupt	573	54	adaptor	adaptor	NN
cord-285262-690kpupt	573	55	TRIF	TRIF	NNP
cord-285262-690kpupt	573	56	is	be	VBZ
cord-285262-690kpupt	573	57	dependent	dependent	JJ
cord-285262-690kpupt	573	58	on	on	IN
cord-285262-690kpupt	573	59	its	-PRON-	PRP$
cord-285262-690kpupt	573	60	receptor	receptor	NN
cord-285262-690kpupt	573	61	interacting	interact	VBG
cord-285262-690kpupt	573	62	protein	protein	JJ
cord-285262-690kpupt	573	63	homotypic	homotypic	JJ
cord-285262-690kpupt	573	64	interaction	interaction	NN
cord-285262-690kpupt	573	65	motif	motif	NN
cord-285262-690kpupt	573	66	Toll	toll	NN
cord-285262-690kpupt	573	67	-	-	HYPH
cord-285262-690kpupt	573	68	like	like	JJ
cord-285262-690kpupt	573	69	receptor	receptor	NN
cord-285262-690kpupt	573	70	3-mediated	3-mediated	CD
cord-285262-690kpupt	573	71	necrosis	necrosis	NN
cord-285262-690kpupt	573	72	via	via	IN
cord-285262-690kpupt	573	73	TRIF	TRIF	NNP
cord-285262-690kpupt	573	74	,	,	,
cord-285262-690kpupt	573	75	RIP3	RIP3	NNP
cord-285262-690kpupt	573	76	,	,	,
cord-285262-690kpupt	573	77	and	and	CC
cord-285262-690kpupt	573	78	MLKL	MLKL	NNP
cord-285262-690kpupt	573	79	IRF8	IRF8	NNP
cord-285262-690kpupt	573	80	regulates	regulate	VBZ
cord-285262-690kpupt	573	81	transcription	transcription	NN
cord-285262-690kpupt	573	82	of	of	IN
cord-285262-690kpupt	573	83	Naips	Naips	NNP
cord-285262-690kpupt	573	84	for	for	IN
cord-285262-690kpupt	573	85	NLRC4	NLRC4	NNP
cord-285262-690kpupt	573	86	inflammasome	inflammasome	NNP
cord-285262-690kpupt	573	87	activation	activation	NN
cord-285262-690kpupt	574	1	The	the	DT
cord-285262-690kpupt	574	2	human	human	JJ
cord-285262-690kpupt	574	3	apoptosis	apoptosis	NN
cord-285262-690kpupt	574	4	inhibitor	inhibitor	NN
cord-285262-690kpupt	574	5	NAIP	NAIP	NNP
cord-285262-690kpupt	574	6	induces	induce	VBZ
cord-285262-690kpupt	574	7	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	574	8	in	in	IN
cord-285262-690kpupt	574	9	macrophages	macrophage	NNS
cord-285262-690kpupt	574	10	infected	infect	VBN
cord-285262-690kpupt	574	11	with	with	IN
cord-285262-690kpupt	574	12	Legionella	Legionella	NNP
cord-285262-690kpupt	574	13	pneumophila	pneumophila	NN
cord-285262-690kpupt	574	14	Differential	differential	JJ
cord-285262-690kpupt	574	15	roles	role	NNS
cord-285262-690kpupt	574	16	of	of	IN
cord-285262-690kpupt	574	17	MDA5	MDA5	NNP
cord-285262-690kpupt	574	18	and	and	CC
cord-285262-690kpupt	574	19	RIG	rig	NN
cord-285262-690kpupt	575	1	-I	-i	DT
cord-285262-690kpupt	575	2	helicases	helicase	NNS
cord-285262-690kpupt	575	3	in	in	IN
cord-285262-690kpupt	575	4	the	the	DT
cord-285262-690kpupt	575	5	recognition	recognition	NN
cord-285262-690kpupt	575	6	of	of	IN
cord-285262-690kpupt	575	7	RNA	RNA	NNP
cord-285262-690kpupt	575	8	viruses	virus	NNS
cord-285262-690kpupt	576	1	Caspase-11	Caspase-11	NNP
cord-285262-690kpupt	576	2	cleaves	cleave	VBZ
cord-285262-690kpupt	576	3	gasdermin	gasdermin	NNP
cord-285262-690kpupt	576	4	D	D	NNP
cord-285262-690kpupt	576	5	for	for	IN
cord-285262-690kpupt	576	6	non	non	JJ
cord-285262-690kpupt	576	7	-	-	JJ
cord-285262-690kpupt	576	8	canonical	canonical	JJ
cord-285262-690kpupt	576	9	inflammasome	inflammasome	NN
cord-285262-690kpupt	576	10	signalling	signal	VBG
cord-285262-690kpupt	576	11	Apoptosis	apoptosis	NN
cord-285262-690kpupt	576	12	:	:	:
cord-285262-690kpupt	577	1	a	a	DT
cord-285262-690kpupt	577	2	basic	basic	JJ
cord-285262-690kpupt	577	3	biological	biological	JJ
cord-285262-690kpupt	577	4	phenomenon	phenomenon	NN
cord-285262-690kpupt	577	5	with	with	IN
cord-285262-690kpupt	577	6	wide	wide	RB
cord-285262-690kpupt	577	7	-	-	HYPH
cord-285262-690kpupt	577	8	ranging	range	VBG
cord-285262-690kpupt	577	9	implications	implication	NNS
cord-285262-690kpupt	577	10	in	in	IN
cord-285262-690kpupt	577	11	tissue	tissue	NN
cord-285262-690kpupt	577	12	kinetics	kinetics	NN
cord-285262-690kpupt	578	1	Listeria	Listeria	NNP
cord-285262-690kpupt	578	2	monocytogenes	monocytogenes	NNP
cord-285262-690kpupt	578	3	is	be	VBZ
cord-285262-690kpupt	578	4	sensed	sense	VBN
cord-285262-690kpupt	578	5	by	by	IN
cord-285262-690kpupt	578	6	the	the	DT
cord-285262-690kpupt	578	7	NLRP3	nlrp3	NN
cord-285262-690kpupt	578	8	and	and	CC
cord-285262-690kpupt	578	9	AIM2	AIM2	NNP
cord-285262-690kpupt	578	10	inflammasome	inflammasome	NN
cord-285262-690kpupt	578	11	Pro	pro	JJ
cord-285262-690kpupt	578	12	-	-	JJ
cord-285262-690kpupt	578	13	apoptotic	apoptotic	JJ
cord-285262-690kpupt	578	14	function	function	NN
cord-285262-690kpupt	578	15	of	of	IN
cord-285262-690kpupt	578	16	HBV	HBV	NNP
cord-285262-690kpupt	578	17	X	X	NNP
cord-285262-690kpupt	578	18	protein	protein	NN
cord-285262-690kpupt	578	19	is	be	VBZ
cord-285262-690kpupt	578	20	mediated	mediate	VBN
cord-285262-690kpupt	578	21	by	by	IN
cord-285262-690kpupt	578	22	interaction	interaction	NN
cord-285262-690kpupt	578	23	with	with	IN
cord-285262-690kpupt	578	24	c	c	NNP
cord-285262-690kpupt	578	25	-	-	:
cord-285262-690kpupt	578	26	FLIP	flip	NN
cord-285262-690kpupt	578	27	and	and	CC
cord-285262-690kpupt	578	28	enhancement	enhancement	NN
cord-285262-690kpupt	578	29	of	of	IN
cord-285262-690kpupt	578	30	death	death	NN
cord-285262-690kpupt	578	31	-	-	HYPH
cord-285262-690kpupt	578	32	inducing	induce	VBG
cord-285262-690kpupt	578	33	signal	signal	NN
cord-285262-690kpupt	578	34	Impact	impact	NN
cord-285262-690kpupt	578	35	of	of	IN
cord-285262-690kpupt	578	36	caspase-1/11	caspase-1/11	NNS
cord-285262-690kpupt	578	37	,	,	,
cord-285262-690kpupt	578	38	-3	-3	NNP
cord-285262-690kpupt	578	39	,	,	,
cord-285262-690kpupt	578	40	-7	-7	NNP
cord-285262-690kpupt	578	41	,	,	,
cord-285262-690kpupt	578	42	or	or	CC
cord-285262-690kpupt	578	43	IL-1β	il-1β	NN
cord-285262-690kpupt	578	44	/	/	,
cord-285262-690kpupt	578	45	IL-18	IL-18	NNP
cord-285262-690kpupt	578	46	deficiency	deficiency	NN
cord-285262-690kpupt	578	47	on	on	IN
cord-285262-690kpupt	578	48	rabies	rabies	NN
cord-285262-690kpupt	578	49	virus	virus	NN
cord-285262-690kpupt	578	50	-	-	HYPH
cord-285262-690kpupt	578	51	induced	induce	VBN
cord-285262-690kpupt	578	52	macrophage	macrophage	NN
cord-285262-690kpupt	578	53	cell	cell	NN
cord-285262-690kpupt	578	54	death	death	NN
cord-285262-690kpupt	578	55	and	and	CC
cord-285262-690kpupt	578	56	onset	onset	NN
cord-285262-690kpupt	578	57	of	of	IN
cord-285262-690kpupt	578	58	disease	disease	NN
cord-285262-690kpupt	578	59	Toxin	toxin	NN
cord-285262-690kpupt	578	60	-	-	HYPH
cord-285262-690kpupt	578	61	induced	induce	VBN
cord-285262-690kpupt	578	62	necroptosis	necroptosis	NN
cord-285262-690kpupt	578	63	is	be	VBZ
cord-285262-690kpupt	578	64	a	a	DT
cord-285262-690kpupt	578	65	major	major	JJ
cord-285262-690kpupt	578	66	mechanism	mechanism	NN
cord-285262-690kpupt	578	67	of	of	IN
cord-285262-690kpupt	578	68	Staphylococcus	Staphylococcus	NNP
cord-285262-690kpupt	578	69	aureus	aureus	NN
cord-285262-690kpupt	578	70	lung	lung	NN
cord-285262-690kpupt	578	71	damage	damage	NN
cord-285262-690kpupt	578	72	Inhibition	inhibition	NN
cord-285262-690kpupt	578	73	of	of	IN
cord-285262-690kpupt	578	74	DAI	DAI	NNP
cord-285262-690kpupt	578	75	-	-	HYPH
cord-285262-690kpupt	578	76	dependent	dependent	JJ
cord-285262-690kpupt	578	77	necroptosis	necroptosis	NN
cord-285262-690kpupt	578	78	by	by	IN
cord-285262-690kpupt	578	79	the	the	DT
cord-285262-690kpupt	578	80	Z	Z	NNP
cord-285262-690kpupt	578	81	-	-	HYPH
cord-285262-690kpupt	578	82	DNA	dna	NN
cord-285262-690kpupt	578	83	binding	binding	NN
cord-285262-690kpupt	578	84	domain	domain	NN
cord-285262-690kpupt	578	85	of	of	IN
cord-285262-690kpupt	578	86	the	the	DT
cord-285262-690kpupt	578	87	vaccinia	vaccinia	NN
cord-285262-690kpupt	578	88	virus	virus	NN
cord-285262-690kpupt	578	89	innate	innate	VBP
cord-285262-690kpupt	578	90	immune	immune	JJ
cord-285262-690kpupt	578	91	evasion	evasion	NN
cord-285262-690kpupt	578	92	protein	protein	NN
cord-285262-690kpupt	578	93	,	,	,
cord-285262-690kpupt	578	94	E3	E3	NNP
cord-285262-690kpupt	578	95	Hepatitis	Hepatitis	NNP
cord-285262-690kpupt	578	96	C	C	NNP
cord-285262-690kpupt	578	97	virus	virus	NN
cord-285262-690kpupt	578	98	infection	infection	NN
cord-285262-690kpupt	578	99	of	of	IN
cord-285262-690kpupt	578	100	cultured	cultured	JJ
cord-285262-690kpupt	578	101	human	human	JJ
cord-285262-690kpupt	578	102	hepatoma	hepatoma	NN
cord-285262-690kpupt	578	103	cells	cell	NNS
cord-285262-690kpupt	579	1	causes	cause	VBZ
cord-285262-690kpupt	579	2	apoptosis	apoptosis	NN
cord-285262-690kpupt	579	3	and	and	CC
cord-285262-690kpupt	579	4	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	579	5	in	in	IN
cord-285262-690kpupt	579	6	both	both	CC
cord-285262-690kpupt	579	7	infected	infect	VBN
cord-285262-690kpupt	579	8	and	and	CC
cord-285262-690kpupt	579	9	bystander	bystander	NN
cord-285262-690kpupt	579	10	cells	cell	NNS
cord-285262-690kpupt	579	11	Chikungunya	chikungunya	NN
cord-285262-690kpupt	579	12	virus	virus	NN
cord-285262-690kpupt	579	13	mobilizes	mobilize	VBZ
cord-285262-690kpupt	579	14	the	the	DT
cord-285262-690kpupt	579	15	apoptotic	apoptotic	JJ
cord-285262-690kpupt	579	16	machinery	machinery	NN
cord-285262-690kpupt	579	17	to	to	TO
cord-285262-690kpupt	579	18	invade	invade	VB
cord-285262-690kpupt	579	19	host	host	NN
cord-285262-690kpupt	579	20	cell	cell	NN
cord-285262-690kpupt	579	21	defenses	defense	NNS
cord-285262-690kpupt	580	1	ZBP1	ZBP1	NNP
cord-285262-690kpupt	580	2	/	/	SYM
cord-285262-690kpupt	580	3	DAI	DAI	NNP
cord-285262-690kpupt	580	4	is	be	VBZ
cord-285262-690kpupt	580	5	an	an	DT
cord-285262-690kpupt	580	6	innate	innate	JJ
cord-285262-690kpupt	580	7	sensor	sensor	NN
cord-285262-690kpupt	580	8	of	of	IN
cord-285262-690kpupt	580	9	influenza	influenza	NN
cord-285262-690kpupt	580	10	virus	virus	NN
cord-285262-690kpupt	580	11	triggering	trigger	VBG
cord-285262-690kpupt	580	12	the	the	DT
cord-285262-690kpupt	580	13	NLRP3	NLRP3	NNP
cord-285262-690kpupt	580	14	inflammasome	inflammasome	NN
cord-285262-690kpupt	580	15	and	and	CC
cord-285262-690kpupt	580	16	programmed	program	VBD
cord-285262-690kpupt	580	17	cell	cell	NN
cord-285262-690kpupt	580	18	death	death	NN
cord-285262-690kpupt	580	19	pathways	pathway	NNS
cord-285262-690kpupt	581	1	IRF1	IRF1	NNP
cord-285262-690kpupt	581	2	is	be	VBZ
cord-285262-690kpupt	581	3	a	a	DT
cord-285262-690kpupt	581	4	transcriptional	transcriptional	JJ
cord-285262-690kpupt	581	5	regulator	regulator	NN
cord-285262-690kpupt	581	6	of	of	IN
cord-285262-690kpupt	581	7	ZBP1	ZBP1	NNP
cord-285262-690kpupt	581	8	promoting	promote	VBG
cord-285262-690kpupt	581	9	NLRP3	NLRP3	NNP
cord-285262-690kpupt	581	10	inflammasome	inflammasome	NNP
cord-285262-690kpupt	581	11	activation	activation	NN
cord-285262-690kpupt	581	12	and	and	CC
cord-285262-690kpupt	581	13	cell	cell	NN
cord-285262-690kpupt	581	14	death	death	NN
cord-285262-690kpupt	581	15	during	during	IN
cord-285262-690kpupt	581	16	influenza	influenza	NN
cord-285262-690kpupt	581	17	virus	virus	NN
cord-285262-690kpupt	581	18	infection	infection	NN
cord-285262-690kpupt	582	1	The	the	DT
cord-285262-690kpupt	582	2	R1	R1	NNP
cord-285262-690kpupt	582	3	subunit	subunit	NN
cord-285262-690kpupt	582	4	of	of	IN
cord-285262-690kpupt	582	5	herpes	herpes	NNP
cord-285262-690kpupt	582	6	simplex	simplex	NNP
cord-285262-690kpupt	582	7	virus	virus	NN
cord-285262-690kpupt	582	8	ribonucleotide	ribonucleotide	NN
cord-285262-690kpupt	582	9	reductase	reductase	NN
cord-285262-690kpupt	582	10	protects	protect	VBZ
cord-285262-690kpupt	582	11	cells	cell	NNS
cord-285262-690kpupt	582	12	against	against	IN
cord-285262-690kpupt	582	13	apoptosis	apoptosis	NN
cord-285262-690kpupt	582	14	at	at	IN
cord-285262-690kpupt	582	15	,	,	,
cord-285262-690kpupt	582	16	or	or	CC
cord-285262-690kpupt	582	17	upstream	upstream	RB
cord-285262-690kpupt	582	18	of	of	IN
cord-285262-690kpupt	582	19	,	,	,
cord-285262-690kpupt	582	20	caspase-8	caspase-8	NNP
cord-285262-690kpupt	582	21	activation	activation	NN
cord-285262-690kpupt	583	1	Influenza	Influenza	NNP
cord-285262-690kpupt	583	2	A	a	DT
cord-285262-690kpupt	583	3	virus	virus	NN
cord-285262-690kpupt	583	4	infection	infection	NN
cord-285262-690kpupt	583	5	triggers	trigger	VBZ
cord-285262-690kpupt	583	6	pyroptosis	pyroptosi	NNS
cord-285262-690kpupt	583	7	and	and	CC
cord-285262-690kpupt	583	8	apoptosis	apoptosis	NN
cord-285262-690kpupt	583	9	of	of	IN
cord-285262-690kpupt	583	10	respiratory	respiratory	JJ
cord-285262-690kpupt	583	11	epithelial	epithelial	JJ
cord-285262-690kpupt	583	12	cells	cell	NNS
cord-285262-690kpupt	583	13	through	through	IN
cord-285262-690kpupt	583	14	the	the	DT
cord-285262-690kpupt	583	15	type	type	NN
cord-285262-690kpupt	583	16	I	-PRON-	PRP
cord-285262-690kpupt	583	17	interferon	interferon	VBP
cord-285262-690kpupt	583	18	signaling	signal	VBG
cord-285262-690kpupt	583	19	pathway	pathway	NN
cord-285262-690kpupt	583	20	in	in	IN
cord-285262-690kpupt	583	21	a	a	DT
cord-285262-690kpupt	583	22	mutually	mutually	RB
cord-285262-690kpupt	583	23	exclusive	exclusive	JJ
cord-285262-690kpupt	583	24	manner	manner	NN
cord-285262-690kpupt	583	25	CYLD	CYLD	NNP
cord-285262-690kpupt	583	26	proteolysis	proteolysis	NN
cord-285262-690kpupt	583	27	protects	protect	VBZ
cord-285262-690kpupt	583	28	macrophages	macrophage	NNS
cord-285262-690kpupt	583	29	from	from	IN
cord-285262-690kpupt	583	30	TNF	TNF	NNP
cord-285262-690kpupt	583	31	-	-	HYPH
cord-285262-690kpupt	583	32	mediated	mediate	VBN
cord-285262-690kpupt	583	33	auto	auto	NN
cord-285262-690kpupt	583	34	-	-	HYPH
cord-285262-690kpupt	583	35	necroptosis	necroptosis	NN
cord-285262-690kpupt	583	36	induced	induce	VBN
cord-285262-690kpupt	583	37	by	by	IN
cord-285262-690kpupt	583	38	LPS	LPS	NNP
cord-285262-690kpupt	583	39	and	and	CC
cord-285262-690kpupt	583	40	licensed	license	VBN
cord-285262-690kpupt	583	41	by	by	IN
cord-285262-690kpupt	583	42	type	type	NN
cord-285262-690kpupt	584	1	I	-PRON-	PRP
cord-285262-690kpupt	584	2	IFN	IFN	NNP
cord-285262-690kpupt	584	3	TLR2	TLR2	NNP
cord-285262-690kpupt	584	4	and	and	CC
cord-285262-690kpupt	584	5	caspase-8	caspase-8	NNP
cord-285262-690kpupt	584	6	are	be	VBP
cord-285262-690kpupt	584	7	essential	essential	JJ
cord-285262-690kpupt	584	8	for	for	IN
cord-285262-690kpupt	584	9	group	group	NN
cord-285262-690kpupt	584	10	B	B	NNP
cord-285262-690kpupt	584	11	Streptococcus	streptococcus	NN
cord-285262-690kpupt	584	12	-	-	HYPH
cord-285262-690kpupt	584	13	induced	induce	VBN
cord-285262-690kpupt	584	14	apoptosis	apoptosis	NN
cord-285262-690kpupt	584	15	in	in	IN
cord-285262-690kpupt	584	16	microglia	microglia	JJ
cord-285262-690kpupt	584	17	Enterovirus	Enterovirus	NNP
cord-285262-690kpupt	584	18	71	71	CD
cord-285262-690kpupt	585	1	inhibits	inhibit	VBZ
cord-285262-690kpupt	585	2	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	585	3	through	through	IN
cord-285262-690kpupt	585	4	cleavage	cleavage	NN
cord-285262-690kpupt	585	5	of	of	IN
cord-285262-690kpupt	585	6	gasdermin	gasdermin	NNP
cord-285262-690kpupt	585	7	D	D	NNP
cord-285262-690kpupt	585	8	Coxsackievirus	Coxsackievirus	NNP
cord-285262-690kpupt	585	9	A16	A16	NNP
cord-285262-690kpupt	585	10	infection	infection	NN
cord-285262-690kpupt	586	1	induces	induce	VBZ
cord-285262-690kpupt	586	2	neural	neural	JJ
cord-285262-690kpupt	586	3	cell	cell	NN
cord-285262-690kpupt	586	4	and	and	CC
cord-285262-690kpupt	586	5	non	non	JJ
cord-285262-690kpupt	586	6	-	-	JJ
cord-285262-690kpupt	586	7	neural	neural	JJ
cord-285262-690kpupt	586	8	cell	cell	NN
cord-285262-690kpupt	586	9	apoptosis	apoptosis	NN
cord-285262-690kpupt	586	10	in	in	IN
cord-285262-690kpupt	586	11	vitro	vitro	FW
cord-285262-690kpupt	586	12	FasL	FasL	NNP
cord-285262-690kpupt	586	13	/	/	SYM
cord-285262-690kpupt	586	14	Fas	Fas	NNP
cord-285262-690kpupt	586	15	pathway	pathway	NN
cord-285262-690kpupt	586	16	is	be	VBZ
cord-285262-690kpupt	586	17	involved	involve	VBN
cord-285262-690kpupt	586	18	in	in	IN
cord-285262-690kpupt	586	19	dengue	dengue	NN
cord-285262-690kpupt	586	20	virus	virus	NN
cord-285262-690kpupt	586	21	induced	induce	VBN
cord-285262-690kpupt	586	22	apoptosis	apoptosis	NN
cord-285262-690kpupt	586	23	of	of	IN
cord-285262-690kpupt	586	24	the	the	DT
cord-285262-690kpupt	586	25	vascular	vascular	JJ
cord-285262-690kpupt	586	26	endothelial	endothelial	JJ
cord-285262-690kpupt	586	27	cells	cell	NNS
cord-285262-690kpupt	586	28	Pathogen	pathogen	NN
cord-285262-690kpupt	586	29	-	-	HYPH
cord-285262-690kpupt	586	30	induced	induce	VBN
cord-285262-690kpupt	586	31	ubiquitin	ubiquitin	NN
cord-285262-690kpupt	586	32	-	-	HYPH
cord-285262-690kpupt	586	33	editing	editing	NN
cord-285262-690kpupt	586	34	enzyme	enzyme	NN
cord-285262-690kpupt	586	35	A20	A20	NNP
cord-285262-690kpupt	586	36	bifunctionally	bifunctionally	NN
cord-285262-690kpupt	586	37	shuts	shut	VBZ
cord-285262-690kpupt	586	38	off	off	RP
cord-285262-690kpupt	586	39	NF	nf	NN
cord-285262-690kpupt	586	40	-	-	HYPH
cord-285262-690kpupt	586	41	κB	κB	NNP
cord-285262-690kpupt	586	42	and	and	CC
cord-285262-690kpupt	586	43	caspase-8-dependent	caspase-8-dependent	JJ
cord-285262-690kpupt	586	44	apoptotic	apoptotic	JJ
cord-285262-690kpupt	586	45	cell	cell	NN
cord-285262-690kpupt	586	46	death	death	NN
cord-285262-690kpupt	587	1	Inflammasome	Inflammasome	NNP
cord-285262-690kpupt	587	2	-	-	HYPH
cord-285262-690kpupt	587	3	activated	activate	VBN
cord-285262-690kpupt	587	4	gasdermin	gasdermin	NNP
cord-285262-690kpupt	587	5	D	D	NNP
cord-285262-690kpupt	587	6	causes	cause	VBZ
cord-285262-690kpupt	587	7	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	587	8	by	by	IN
cord-285262-690kpupt	587	9	forming	form	VBG
cord-285262-690kpupt	587	10	membrane	membrane	NN
cord-285262-690kpupt	587	11	pores	pore	NNS
cord-285262-690kpupt	588	1	Epstein	Epstein	NNP
cord-285262-690kpupt	588	2	-	-	HYPH
cord-285262-690kpupt	588	3	Barr	Barr	NNP
cord-285262-690kpupt	588	4	virus	virus	NN
cord-285262-690kpupt	588	5	encoded	encode	VBD
cord-285262-690kpupt	588	6	latent	latent	JJ
cord-285262-690kpupt	588	7	membrane	membrane	NN
cord-285262-690kpupt	588	8	protein	protein	NN
cord-285262-690kpupt	588	9	1	1	CD
cord-285262-690kpupt	588	10	suppresses	suppress	VBZ
cord-285262-690kpupt	588	11	necroptosis	necroptosis	NNP
cord-285262-690kpupt	588	12	through	through	IN
cord-285262-690kpupt	588	13	targeting	target	VBG
cord-285262-690kpupt	588	14	RIPK1/3	RIPK1/3	NNP
cord-285262-690kpupt	588	15	ubiquitination	ubiquitination	NN
cord-285262-690kpupt	589	1	The	the	DT
cord-285262-690kpupt	589	2	19-kDa	19-kda	CD
cord-285262-690kpupt	589	3	Mycobacterium	Mycobacterium	NNP
cord-285262-690kpupt	589	4	tuberculosis	tuberculosis	NN
cord-285262-690kpupt	589	5	protein	protein	NN
cord-285262-690kpupt	589	6	induces	induce	VBZ
cord-285262-690kpupt	589	7	macrophage	macrophage	NN
cord-285262-690kpupt	589	8	apoptosis	apoptosis	NN
cord-285262-690kpupt	589	9	through	through	IN
cord-285262-690kpupt	589	10	Toll	Toll	NNP
cord-285262-690kpupt	589	11	-	-	HYPH
cord-285262-690kpupt	589	12	like	like	JJ
cord-285262-690kpupt	589	13	receptor-2	receptor-2	NNP
cord-285262-690kpupt	589	14	Rhinovirus	Rhinovirus	NNP
cord-285262-690kpupt	589	15	3C	3c	NN
cord-285262-690kpupt	589	16	protease	protease	NN
cord-285262-690kpupt	589	17	suppresses	suppress	VBZ
cord-285262-690kpupt	589	18	apoptosis	apoptosis	NN
cord-285262-690kpupt	589	19	and	and	CC
cord-285262-690kpupt	589	20	triggers	trigger	VBZ
cord-285262-690kpupt	589	21	caspase	caspase	NN
cord-285262-690kpupt	589	22	-	-	HYPH
cord-285262-690kpupt	589	23	independent	independent	JJ
cord-285262-690kpupt	589	24	cell	cell	NN
cord-285262-690kpupt	589	25	death	death	NN
cord-285262-690kpupt	590	1	A	a	DT
cord-285262-690kpupt	590	2	null	null	JJ
cord-285262-690kpupt	590	3	mutation	mutation	NN
cord-285262-690kpupt	590	4	in	in	IN
cord-285262-690kpupt	590	5	the	the	DT
cord-285262-690kpupt	590	6	perforin	perforin	NNP
cord-285262-690kpupt	590	7	gene	gene	NN
cord-285262-690kpupt	590	8	impairs	impair	VBZ
cord-285262-690kpupt	590	9	cytolytic	cytolytic	NNP
cord-285262-690kpupt	590	10	T	T	NNP
cord-285262-690kpupt	590	11	lymphocyte	lymphocyte	NN
cord-285262-690kpupt	590	12	-	-	:
cord-285262-690kpupt	590	13	and	and	CC
cord-285262-690kpupt	590	14	natural	natural	JJ
cord-285262-690kpupt	590	15	killer	killer	NN
cord-285262-690kpupt	590	16	cell	cell	NN
cord-285262-690kpupt	590	17	-	-	HYPH
cord-285262-690kpupt	590	18	mediated	mediate	VBN
cord-285262-690kpupt	590	19	cytotoxicity	cytotoxicity	NN
cord-285262-690kpupt	590	20	Novel	Novel	NNP
cord-285262-690kpupt	590	21	role	role	NN
cord-285262-690kpupt	590	22	of	of	IN
cord-285262-690kpupt	590	23	PKR	PKR	NNP
cord-285262-690kpupt	590	24	in	in	IN
cord-285262-690kpupt	590	25	inflammasome	inflammasome	NN
cord-285262-690kpupt	590	26	activation	activation	NN
cord-285262-690kpupt	590	27	and	and	CC
cord-285262-690kpupt	591	1	HMGB1	HMGB1	NNP
cord-285262-690kpupt	591	2	release	release	VB
cord-285262-690kpupt	591	3	Molecular	molecular	JJ
cord-285262-690kpupt	591	4	cell	cell	NN
cord-285262-690kpupt	591	5	death	death	NN
cord-285262-690kpupt	591	6	platforms	platform	NNS
cord-285262-690kpupt	591	7	and	and	CC
cord-285262-690kpupt	592	1	assemblies	assembly	NNS
cord-285262-690kpupt	592	2	Salmonella	Salmonella	NNP
cord-285262-690kpupt	592	3	infection	infection	NN
cord-285262-690kpupt	592	4	induces	induce	VBZ
cord-285262-690kpupt	592	5	recruitment	recruitment	NN
cord-285262-690kpupt	592	6	of	of	IN
cord-285262-690kpupt	592	7	Caspase-8	Caspase-8	NNP
cord-285262-690kpupt	592	8	to	to	IN
cord-285262-690kpupt	592	9	the	the	DT
cord-285262-690kpupt	592	10	inflammasome	inflammasome	NN
cord-285262-690kpupt	592	11	to	to	TO
cord-285262-690kpupt	592	12	modulate	modulate	VB
cord-285262-690kpupt	592	13	IL-1β	il-1β	NN
cord-285262-690kpupt	592	14	production	production	NN
cord-285262-690kpupt	593	1	The	the	DT
cord-285262-690kpupt	593	2	transcription	transcription	NN
cord-285262-690kpupt	593	3	factor	factor	NN
cord-285262-690kpupt	593	4	IRF1	IRF1	NNP
cord-285262-690kpupt	593	5	and	and	CC
cord-285262-690kpupt	593	6	guanylate	guanylate	NN
cord-285262-690kpupt	593	7	-	-	HYPH
cord-285262-690kpupt	593	8	binding	bind	VBG
cord-285262-690kpupt	593	9	proteins	protein	NNS
cord-285262-690kpupt	593	10	target	target	VBP
cord-285262-690kpupt	593	11	activation	activation	NN
cord-285262-690kpupt	593	12	of	of	IN
cord-285262-690kpupt	593	13	the	the	DT
cord-285262-690kpupt	593	14	AIM2	AIM2	NNP
cord-285262-690kpupt	593	15	inflammasome	inflammasome	NN
cord-285262-690kpupt	593	16	by	by	IN
cord-285262-690kpupt	593	17	Francisella	Francisella	NNP
cord-285262-690kpupt	593	18	infection	infection	NN
cord-285262-690kpupt	594	1	IRGB10	irgb10	DT
cord-285262-690kpupt	594	2	liberates	liberate	VBZ
cord-285262-690kpupt	594	3	bacterial	bacterial	JJ
cord-285262-690kpupt	594	4	ligands	ligand	NNS
cord-285262-690kpupt	594	5	for	for	IN
cord-285262-690kpupt	594	6	sensing	sensing	NN
cord-285262-690kpupt	594	7	by	by	IN
cord-285262-690kpupt	594	8	the	the	DT
cord-285262-690kpupt	594	9	AIM2	AIM2	NNP
cord-285262-690kpupt	594	10	and	and	CC
cord-285262-690kpupt	594	11	caspase-11-NLRP3	caspase-11-NLRP3	NNP
cord-285262-690kpupt	594	12	inflammasomes	inflammasome	NNS
cord-285262-690kpupt	595	1	Molecular	molecular	JJ
cord-285262-690kpupt	595	2	mechanisms	mechanism	NNS
cord-285262-690kpupt	595	3	and	and	CC
cord-285262-690kpupt	595	4	functions	function	NNS
cord-285262-690kpupt	595	5	of	of	IN
cord-285262-690kpupt	595	6	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	595	7	,	,	,
cord-285262-690kpupt	595	8	inflammatory	inflammatory	JJ
cord-285262-690kpupt	595	9	caspases	caspase	NNS
cord-285262-690kpupt	595	10	and	and	CC
cord-285262-690kpupt	595	11	inflammasomes	inflammasome	NNS
cord-285262-690kpupt	595	12	in	in	IN
cord-285262-690kpupt	595	13	infectious	infectious	JJ
cord-285262-690kpupt	595	14	diseases	disease	NNS
cord-285262-690kpupt	595	15	Detection	detection	NN
cord-285262-690kpupt	595	16	of	of	IN
cord-285262-690kpupt	595	17	immune	immune	JJ
cord-285262-690kpupt	595	18	danger	danger	NN
cord-285262-690kpupt	595	19	signals	signal	NNS
cord-285262-690kpupt	595	20	by	by	IN
cord-285262-690kpupt	595	21	NALP3	NALP3	NNP
cord-285262-690kpupt	595	22	Gout	Gout	NNP
cord-285262-690kpupt	595	23	-	-	HYPH
cord-285262-690kpupt	595	24	associated	associate	VBN
cord-285262-690kpupt	595	25	uric	uric	NN
cord-285262-690kpupt	595	26	acid	acid	NN
cord-285262-690kpupt	595	27	crystals	crystal	NNS
cord-285262-690kpupt	595	28	activate	activate	VBP
cord-285262-690kpupt	595	29	the	the	DT
cord-285262-690kpupt	595	30	NALP3	NALP3	NNP
cord-285262-690kpupt	595	31	inflammasome	inflammasome	NNP
cord-285262-690kpupt	595	32	Human	Human	NNP
cord-285262-690kpupt	595	33	T	T	NNP
cord-285262-690kpupt	595	34	-	-	HYPH
cord-285262-690kpupt	595	35	cell	cell	NN
cord-285262-690kpupt	595	36	leukaemia	leukaemia	NN
cord-285262-690kpupt	595	37	virus	virus	NN
cord-285262-690kpupt	595	38	type	type	NN
cord-285262-690kpupt	595	39	1	1	CD
cord-285262-690kpupt	595	40	(	(	-LRB-
cord-285262-690kpupt	595	41	HTLV-1	HTLV-1	NNP
cord-285262-690kpupt	595	42	)	)	-RRB-
cord-285262-690kpupt	595	43	infectivity	infectivity	NN
cord-285262-690kpupt	595	44	and	and	CC
cord-285262-690kpupt	595	45	cellular	cellular	JJ
cord-285262-690kpupt	595	46	transformation	transformation	NN
cord-285262-690kpupt	595	47	Flagellin	Flagellin	NNP
cord-285262-690kpupt	595	48	-	-	HYPH
cord-285262-690kpupt	595	49	induced	induce	VBN
cord-285262-690kpupt	595	50	NLRC4	NLRC4	NNP
cord-285262-690kpupt	595	51	phosphorylation	phosphorylation	NN
cord-285262-690kpupt	595	52	primes	prime	VBZ
cord-285262-690kpupt	595	53	the	the	DT
cord-285262-690kpupt	595	54	inflammasome	inflammasome	NN
cord-285262-690kpupt	595	55	for	for	IN
cord-285262-690kpupt	595	56	activation	activation	NN
cord-285262-690kpupt	595	57	by	by	IN
cord-285262-690kpupt	595	58	NAIP5	NAIP5	NNP
cord-285262-690kpupt	595	59	TLR3	TLR3	NNP
cord-285262-690kpupt	595	60	,	,	,
cord-285262-690kpupt	595	61	TRIF	TRIF	NNP
cord-285262-690kpupt	595	62	,	,	,
cord-285262-690kpupt	595	63	and	and	CC
cord-285262-690kpupt	595	64	caspase	caspase	NN
cord-285262-690kpupt	596	1	8	8	CD
cord-285262-690kpupt	596	2	determine	determine	VBP
cord-285262-690kpupt	596	3	double	double	RB
cord-285262-690kpupt	596	4	-	-	HYPH
cord-285262-690kpupt	596	5	stranded	strand	VBN
cord-285262-690kpupt	596	6	RNA	rna	NN
cord-285262-690kpupt	596	7	-	-	HYPH
cord-285262-690kpupt	596	8	induced	induce	VBN
cord-285262-690kpupt	596	9	epithelial	epithelial	JJ
cord-285262-690kpupt	596	10	cell	cell	NN
cord-285262-690kpupt	596	11	death	death	NN
cord-285262-690kpupt	596	12	and	and	CC
cord-285262-690kpupt	596	13	survival	survival	NN
cord-285262-690kpupt	596	14	in	in	IN
cord-285262-690kpupt	596	15	vivo	vivo	NNP
cord-285262-690kpupt	596	16	Francisella	Francisella	NNP
cord-285262-690kpupt	596	17	tularensis	tularensis	NNP
cord-285262-690kpupt	596	18	modulates	modulate	VBZ
cord-285262-690kpupt	596	19	a	a	DT
cord-285262-690kpupt	596	20	distinct	distinct	JJ
cord-285262-690kpupt	596	21	subset	subset	NN
cord-285262-690kpupt	596	22	of	of	IN
cord-285262-690kpupt	596	23	regulatory	regulatory	JJ
cord-285262-690kpupt	596	24	factors	factor	NNS
cord-285262-690kpupt	596	25	and	and	CC
cord-285262-690kpupt	596	26	sustains	sustain	VBZ
cord-285262-690kpupt	596	27	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	596	28	integrity	integrity	NN
cord-285262-690kpupt	596	29	to	to	TO
cord-285262-690kpupt	596	30	impair	impair	VB
cord-285262-690kpupt	596	31	human	human	JJ
cord-285262-690kpupt	596	32	neutrophil	neutrophil	NN
cord-285262-690kpupt	596	33	apoptosis	apoptosis	NN
cord-285262-690kpupt	597	1	Positive	positive	JJ
cord-285262-690kpupt	597	2	and	and	CC
cord-285262-690kpupt	597	3	negative	negative	JJ
cord-285262-690kpupt	597	4	phosphorylation	phosphorylation	NN
cord-285262-690kpupt	597	5	regulates	regulate	VBZ
cord-285262-690kpupt	598	1	RIP1-and	rip1-and	UH
cord-285262-690kpupt	598	2	RIP3-induced	RIP3-induced	NNP
cord-285262-690kpupt	598	3	programmed	program	VBD
cord-285262-690kpupt	598	4	necrosis	necrosis	NN
cord-285262-690kpupt	598	5	Pivotal	pivotal	JJ
cord-285262-690kpupt	598	6	role	role	NN
cord-285262-690kpupt	598	7	of	of	IN
cord-285262-690kpupt	598	8	receptor	receptor	NN
cord-285262-690kpupt	598	9	-	-	HYPH
cord-285262-690kpupt	598	10	interacting	interact	VBG
cord-285262-690kpupt	598	11	protein	protein	NN
cord-285262-690kpupt	598	12	kinase	kinase	NN
cord-285262-690kpupt	598	13	1	1	CD
cord-285262-690kpupt	598	14	and	and	CC
cord-285262-690kpupt	599	1	mixed	mixed	JJ
cord-285262-690kpupt	599	2	lineage	lineage	NN
cord-285262-690kpupt	599	3	kinase	kinase	NN
cord-285262-690kpupt	599	4	domain	domain	NN
cord-285262-690kpupt	599	5	-	-	:
cord-285262-690kpupt	599	6	like	like	JJ
cord-285262-690kpupt	599	7	in	in	IN
cord-285262-690kpupt	599	8	neuronal	neuronal	JJ
cord-285262-690kpupt	599	9	cell	cell	NN
cord-285262-690kpupt	599	10	death	death	NN
cord-285262-690kpupt	599	11	induced	induce	VBN
cord-285262-690kpupt	599	12	by	by	IN
cord-285262-690kpupt	599	13	the	the	DT
cord-285262-690kpupt	599	14	human	human	JJ
cord-285262-690kpupt	599	15	neuroinvasive	neuroinvasive	JJ
cord-285262-690kpupt	599	16	coronavirus	coronavirus	NN
cord-285262-690kpupt	599	17	OC43	OC43	NNP
cord-285262-690kpupt	599	18	High	High	NNP
cord-285262-690kpupt	599	19	mobility	mobility	NN
cord-285262-690kpupt	599	20	group	group	NN
cord-285262-690kpupt	599	21	box	box	NN
cord-285262-690kpupt	599	22	1	1	CD
cord-285262-690kpupt	599	23	enables	enable	VBZ
cord-285262-690kpupt	599	24	bacterial	bacterial	JJ
cord-285262-690kpupt	599	25	lipids	lipid	NNS
cord-285262-690kpupt	599	26	to	to	TO
cord-285262-690kpupt	599	27	trigger	trigger	VB
cord-285262-690kpupt	599	28	receptor	receptor	NN
cord-285262-690kpupt	599	29	-	-	HYPH
cord-285262-690kpupt	599	30	interacting	interact	VBG
cord-285262-690kpupt	599	31	protein	protein	NN
cord-285262-690kpupt	599	32	kinase	kinase	NN
cord-285262-690kpupt	599	33	3	3	CD
cord-285262-690kpupt	599	34	(	(	-LRB-
cord-285262-690kpupt	599	35	RIPK3)-mediated	ripk3)-mediated	JJ
cord-285262-690kpupt	599	36	necroptosis	necroptosis	NN
cord-285262-690kpupt	599	37	and	and	CC
cord-285262-690kpupt	599	38	apoptosis	apoptosis	NN
cord-285262-690kpupt	599	39	in	in	IN
cord-285262-690kpupt	600	1	mice	mouse	NNS
cord-285262-690kpupt	600	2	Caspase-11	caspase-11	XX
cord-285262-690kpupt	600	3	activation	activation	NN
cord-285262-690kpupt	600	4	requires	require	VBZ
cord-285262-690kpupt	600	5	lysis	lysis	NN
cord-285262-690kpupt	600	6	of	of	IN
cord-285262-690kpupt	600	7	pathogen	pathogen	NN
cord-285262-690kpupt	600	8	-	-	HYPH
cord-285262-690kpupt	600	9	containing	contain	VBG
cord-285262-690kpupt	600	10	vacuoles	vacuole	NNS
cord-285262-690kpupt	600	11	by	by	IN
cord-285262-690kpupt	600	12	IFNinduced	IFNinduced	NNP
cord-285262-690kpupt	600	13	GTPases	GTPases	NNP
cord-285262-690kpupt	600	14	Caspase-1-induced	Caspase-1-induced	NNP
cord-285262-690kpupt	600	15	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	600	16	is	be	VBZ
cord-285262-690kpupt	600	17	an	an	DT
cord-285262-690kpupt	600	18	innate	innate	JJ
cord-285262-690kpupt	600	19	immune	immune	JJ
cord-285262-690kpupt	600	20	effector	effector	NN
cord-285262-690kpupt	600	21	mechanism	mechanism	NN
cord-285262-690kpupt	600	22	against	against	IN
cord-285262-690kpupt	600	23	intracellular	intracellular	JJ
cord-285262-690kpupt	600	24	bacteria	bacteria	NNS
cord-285262-690kpupt	600	25	Salmonella	salmonella	NN
cord-285262-690kpupt	600	26	-	-	HYPH
cord-285262-690kpupt	600	27	induced	induce	VBN
cord-285262-690kpupt	600	28	macrophage	macrophage	NN
cord-285262-690kpupt	600	29	death	death	NN
cord-285262-690kpupt	600	30	:	:	:
cord-285262-690kpupt	600	31	the	the	DT
cord-285262-690kpupt	600	32	role	role	NN
cord-285262-690kpupt	600	33	of	of	IN
cord-285262-690kpupt	600	34	caspase-1	caspase-1	NNP
cord-285262-690kpupt	600	35	in	in	IN
cord-285262-690kpupt	600	36	death	death	NN
cord-285262-690kpupt	600	37	and	and	CC
cord-285262-690kpupt	600	38	inflammation	inflammation	NN
cord-285262-690kpupt	600	39	IFI16	ifi16	NN
cord-285262-690kpupt	600	40	DNA	dna	NN
cord-285262-690kpupt	600	41	sensor	sensor	NN
cord-285262-690kpupt	600	42	is	be	VBZ
cord-285262-690kpupt	600	43	required	require	VBN
cord-285262-690kpupt	600	44	for	for	IN
cord-285262-690kpupt	600	45	death	death	NN
cord-285262-690kpupt	600	46	of	of	IN
cord-285262-690kpupt	600	47	lymphoid	lymphoid	JJ
cord-285262-690kpupt	600	48	CD4	CD4	NNP
cord-285262-690kpupt	600	49	T	T	NNP
cord-285262-690kpupt	600	50	cells	cell	NNS
cord-285262-690kpupt	600	51	abortively	abortively	RB
cord-285262-690kpupt	600	52	infected	infect	VBN
cord-285262-690kpupt	600	53	with	with	IN
cord-285262-690kpupt	600	54	HIV	HIV	NNP
cord-285262-690kpupt	600	55	K	K	NNP
cord-285262-690kpupt	601	1	+	+	CC
cord-285262-690kpupt	601	2	efflux	efflux	NN
cord-285262-690kpupt	601	3	is	be	VBZ
cord-285262-690kpupt	601	4	the	the	DT
cord-285262-690kpupt	601	5	common	common	JJ
cord-285262-690kpupt	601	6	trigger	trigger	NN
cord-285262-690kpupt	601	7	of	of	IN
cord-285262-690kpupt	601	8	NLRP3	NLRP3	NNP
cord-285262-690kpupt	601	9	inflammasome	inflammasome	NNP
cord-285262-690kpupt	601	10	activation	activation	NN
cord-285262-690kpupt	601	11	by	by	IN
cord-285262-690kpupt	601	12	bacterial	bacterial	JJ
cord-285262-690kpupt	601	13	toxins	toxin	NNS
cord-285262-690kpupt	601	14	and	and	CC
cord-285262-690kpupt	601	15	particulate	particulate	NN
cord-285262-690kpupt	601	16	matter	matter	NN
cord-285262-690kpupt	602	1	Intracellular	Intracellular	NNP
cord-285262-690kpupt	602	2	bacteria	bacteria	NNS
cord-285262-690kpupt	602	3	engage	engage	VBP
cord-285262-690kpupt	602	4	a	a	DT
cord-285262-690kpupt	602	5	STING	sting	NN
cord-285262-690kpupt	602	6	-	-	HYPH
cord-285262-690kpupt	602	7	TBK1-MVB12b	tbk1-mvb12b	NN
cord-285262-690kpupt	602	8	pathway	pathway	NN
cord-285262-690kpupt	602	9	to	to	TO
cord-285262-690kpupt	602	10	enable	enable	VB
cord-285262-690kpupt	602	11	paracrine	paracrine	JJ
cord-285262-690kpupt	602	12	cGAS	cgas	NN
cord-285262-690kpupt	602	13	-	-	HYPH
cord-285262-690kpupt	602	14	STING	sting	NN
cord-285262-690kpupt	602	15	signalling	signal	VBG
cord-285262-690kpupt	602	16	Regulation	regulation	NN
cord-285262-690kpupt	602	17	of	of	IN
cord-285262-690kpupt	602	18	viral	viral	JJ
cord-285262-690kpupt	602	19	replication	replication	NN
cord-285262-690kpupt	602	20	,	,	,
cord-285262-690kpupt	602	21	apoptosis	apoptosis	NN
cord-285262-690kpupt	602	22	and	and	CC
cord-285262-690kpupt	602	23	proinflammatory	proinflammatory	JJ
cord-285262-690kpupt	602	24	responses	response	NNS
cord-285262-690kpupt	602	25	by	by	IN
cord-285262-690kpupt	602	26	17-AAG	17-aag	CD
cord-285262-690kpupt	602	27	during	during	IN
cord-285262-690kpupt	602	28	chikungunya	chikungunya	NN
cord-285262-690kpupt	602	29	virus	virus	NN
cord-285262-690kpupt	602	30	infection	infection	NN
cord-285262-690kpupt	602	31	in	in	IN
cord-285262-690kpupt	602	32	macrophages	macrophage	NNS
cord-285262-690kpupt	602	33	RIPK1	RIPK1	NNP
cord-285262-690kpupt	602	34	inhibits	inhibit	VBZ
cord-285262-690kpupt	602	35	ZBP1-driven	ZBP1-driven	NNP
cord-285262-690kpupt	602	36	necroptosis	necroptosis	NNP
cord-285262-690kpupt	602	37	during	during	IN
cord-285262-690kpupt	602	38	development	development	NN
cord-285262-690kpupt	602	39	Apoptotic	Apoptotic	NNP
cord-285262-690kpupt	602	40	caspases	caspase	NNS
cord-285262-690kpupt	603	1	suppress	suppress	VB
cord-285262-690kpupt	603	2	type	type	NN
cord-285262-690kpupt	604	1	I	-PRON-	PRP
cord-285262-690kpupt	605	1	interferon	interferon	NN
cord-285262-690kpupt	605	2	production	production	NN
cord-285262-690kpupt	605	3	via	via	IN
cord-285262-690kpupt	605	4	the	the	DT
cord-285262-690kpupt	605	5	cleavage	cleavage	NN
cord-285262-690kpupt	605	6	of	of	IN
cord-285262-690kpupt	605	7	cGAS	cgas	NN
cord-285262-690kpupt	605	8	,	,	,
cord-285262-690kpupt	605	9	MAVS	mavs	UH
cord-285262-690kpupt	605	10	,	,	,
cord-285262-690kpupt	605	11	and	and	CC
cord-285262-690kpupt	605	12	IRF3	IRF3	NNP
cord-285262-690kpupt	605	13	RIPK3	ripk3	NN
cord-285262-690kpupt	605	14	activates	activate	VBZ
cord-285262-690kpupt	605	15	parallel	parallel	JJ
cord-285262-690kpupt	605	16	pathways	pathway	NNS
cord-285262-690kpupt	605	17	of	of	IN
cord-285262-690kpupt	605	18	MLKL	MLKL	NNP
cord-285262-690kpupt	605	19	-	-	HYPH
cord-285262-690kpupt	605	20	driven	drive	VBN
cord-285262-690kpupt	605	21	necroptosis	necroptosis	NN
cord-285262-690kpupt	605	22	and	and	CC
cord-285262-690kpupt	605	23	FADD	FADD	NNP
cord-285262-690kpupt	605	24	-	-	HYPH
cord-285262-690kpupt	605	25	mediated	mediate	VBN
cord-285262-690kpupt	605	26	apoptosis	apoptosis	NN
cord-285262-690kpupt	605	27	to	to	TO
cord-285262-690kpupt	605	28	protect	protect	VB
cord-285262-690kpupt	605	29	against	against	IN
cord-285262-690kpupt	605	30	influenza	influenza	NN
cord-285262-690kpupt	605	31	A	a	DT
cord-285262-690kpupt	605	32	virus	virus	NN
cord-285262-690kpupt	605	33	Stable	stable	JJ
cord-285262-690kpupt	605	34	extracellular	extracellular	JJ
cord-285262-690kpupt	605	35	RNA	rna	NN
cord-285262-690kpupt	605	36	fragments	fragment	NNS
cord-285262-690kpupt	605	37	of	of	IN
cord-285262-690kpupt	605	38	Mycobacterium	Mycobacterium	NNP
cord-285262-690kpupt	605	39	tuberculosis	tuberculosis	NN
cord-285262-690kpupt	605	40	induce	induce	VBP
cord-285262-690kpupt	605	41	early	early	JJ
cord-285262-690kpupt	605	42	apoptosis	apoptosis	NN
cord-285262-690kpupt	605	43	in	in	IN
cord-285262-690kpupt	605	44	human	human	JJ
cord-285262-690kpupt	605	45	monocytes	monocyte	NNS
cord-285262-690kpupt	605	46	via	via	IN
cord-285262-690kpupt	605	47	a	a	DT
cord-285262-690kpupt	605	48	caspase-8	caspase-8	NNP
cord-285262-690kpupt	605	49	dependent	dependent	JJ
cord-285262-690kpupt	605	50	mechanism	mechanism	NN
cord-285262-690kpupt	606	1	Caspase	Caspase	NNP
cord-285262-690kpupt	606	2	8	8	CD
cord-285262-690kpupt	606	3	inhibits	inhibit	VBZ
cord-285262-690kpupt	606	4	programmed	program	VBN
cord-285262-690kpupt	606	5	necrosis	necrosis	NN
cord-285262-690kpupt	606	6	by	by	IN
cord-285262-690kpupt	606	7	processing	process	VBG
cord-285262-690kpupt	606	8	CYLD	CYLD	NNP
cord-285262-690kpupt	606	9	Human	Human	NNP
cord-285262-690kpupt	606	10	T	T	NNP
cord-285262-690kpupt	606	11	-	-	HYPH
cord-285262-690kpupt	606	12	cell	cell	NN
cord-285262-690kpupt	606	13	leukemia	leukemia	NN
cord-285262-690kpupt	606	14	virus	virus	NN
cord-285262-690kpupt	606	15	type	type	NN
cord-285262-690kpupt	606	16	-	-	:
cord-285262-690kpupt	606	17	I	-PRON-	PRP
cord-285262-690kpupt	606	18	oncoprotein	oncoprotein	NNP
cord-285262-690kpupt	606	19	Tax	Tax	NNP
cord-285262-690kpupt	606	20	inhibits	inhibit	VBZ
cord-285262-690kpupt	606	21	Fas	Fas	NNP
cord-285262-690kpupt	606	22	-	-	HYPH
cord-285262-690kpupt	606	23	mediated	mediate	VBN
cord-285262-690kpupt	606	24	apoptosis	apoptosis	NN
cord-285262-690kpupt	606	25	by	by	IN
cord-285262-690kpupt	606	26	inducing	induce	VBG
cord-285262-690kpupt	606	27	cellular	cellular	JJ
cord-285262-690kpupt	606	28	FLIP	flip	NN
cord-285262-690kpupt	606	29	through	through	IN
cord-285262-690kpupt	606	30	activation	activation	NN
cord-285262-690kpupt	606	31	of	of	IN
cord-285262-690kpupt	606	32	NF	NF	NNP
cord-285262-690kpupt	606	33	-	-	HYPH
cord-285262-690kpupt	606	34	kappaB	kappaB	NNP
cord-285262-690kpupt	606	35	Caspase-2	Caspase-2	NNP
cord-285262-690kpupt	606	36	:	:	:
cord-285262-690kpupt	607	1	the	the	DT
cord-285262-690kpupt	607	2	reinvented	reinvent	VBN
cord-285262-690kpupt	607	3	enzyme	enzyme	NN
cord-285262-690kpupt	607	4	Suppression	suppression	NN
cord-285262-690kpupt	607	5	of	of	IN
cord-285262-690kpupt	607	6	RIP3-dependent	RIP3-dependent	NNP
cord-285262-690kpupt	607	7	necroptosis	necroptosis	NNP
cord-285262-690kpupt	607	8	by	by	IN
cord-285262-690kpupt	607	9	human	human	JJ
cord-285262-690kpupt	607	10	cytomegalovirus	cytomegalovirus	NNP
cord-285262-690kpupt	607	11	Pathogen	Pathogen	NNP
cord-285262-690kpupt	607	12	blockade	blockade	NN
cord-285262-690kpupt	607	13	of	of	IN
cord-285262-690kpupt	607	14	TAK1	TAK1	NNP
cord-285262-690kpupt	607	15	triggers	trigger	VBZ
cord-285262-690kpupt	607	16	caspase-8-dependent	caspase-8-dependent	JJ
cord-285262-690kpupt	607	17	cleavage	cleavage	NN
cord-285262-690kpupt	607	18	of	of	IN
cord-285262-690kpupt	607	19	gasdermin	gasdermin	NN
cord-285262-690kpupt	607	20	D	D	NNP
cord-285262-690kpupt	607	21	and	and	CC
cord-285262-690kpupt	607	22	cell	cell	NN
cord-285262-690kpupt	607	23	death	death	NN
cord-285262-690kpupt	608	1	NAD+	NAD+	NNP
cord-285262-690kpupt	608	2	depletion	depletion	NN
cord-285262-690kpupt	608	3	triggers	trigger	NNS
cord-285262-690kpupt	609	1	macrophage	macrophage	NNP
cord-285262-690kpupt	609	2	necroptosis	necroptosis	NNP
cord-285262-690kpupt	609	3	,	,	,
cord-285262-690kpupt	609	4	a	a	DT
cord-285262-690kpupt	609	5	cell	cell	NN
cord-285262-690kpupt	609	6	death	death	NN
cord-285262-690kpupt	609	7	pathway	pathway	NN
cord-285262-690kpupt	609	8	exploited	exploit	VBN
cord-285262-690kpupt	609	9	by	by	IN
cord-285262-690kpupt	609	10	Mycobacterium	Mycobacterium	NNP
cord-285262-690kpupt	609	11	tuberculosis	tuberculosis	NN
cord-285262-690kpupt	609	12	Necroptosis	Necroptosis	NNP
cord-285262-690kpupt	609	13	takes	take	VBZ
cord-285262-690kpupt	609	14	place	place	NN
cord-285262-690kpupt	609	15	in	in	IN
cord-285262-690kpupt	609	16	human	human	JJ
cord-285262-690kpupt	609	17	immunodeficiency	immunodeficiency	NN
cord-285262-690kpupt	609	18	virus	virus	NN
cord-285262-690kpupt	609	19	type-1	type-1	NN
cord-285262-690kpupt	609	20	(	(	-LRB-
cord-285262-690kpupt	609	21	HIV-1)-infected	HIV-1)-infected	NNP
cord-285262-690kpupt	609	22	CD4	CD4	NNP
cord-285262-690kpupt	609	23	+	+	CC
cord-285262-690kpupt	609	24	T	t	NN
cord-285262-690kpupt	609	25	lymphocytes	lymphocyte	NNS
cord-285262-690kpupt	610	1	A	a	DT
cord-285262-690kpupt	610	2	type	type	NN
cord-285262-690kpupt	610	3	III	iii	CD
cord-285262-690kpupt	610	4	effector	effector	NN
cord-285262-690kpupt	610	5	antagonizes	antagonize	VBZ
cord-285262-690kpupt	610	6	death	death	NN
cord-285262-690kpupt	610	7	receptor	receptor	NN
cord-285262-690kpupt	610	8	signalling	signal	VBG
cord-285262-690kpupt	610	9	during	during	IN
cord-285262-690kpupt	610	10	bacterial	bacterial	JJ
cord-285262-690kpupt	610	11	gut	gut	NN
cord-285262-690kpupt	610	12	infection	infection	NN
cord-285262-690kpupt	610	13	EspL	EspL	NNP
cord-285262-690kpupt	610	14	is	be	VBZ
cord-285262-690kpupt	610	15	a	a	DT
cord-285262-690kpupt	610	16	bacterial	bacterial	JJ
cord-285262-690kpupt	610	17	cysteine	cysteine	NN
cord-285262-690kpupt	610	18	protease	protease	NN
cord-285262-690kpupt	610	19	effector	effector	NN
cord-285262-690kpupt	610	20	that	that	WDT
cord-285262-690kpupt	610	21	cleaves	cleave	VBZ
cord-285262-690kpupt	610	22	RHIM	rhim	NN
cord-285262-690kpupt	610	23	proteins	protein	NNS
cord-285262-690kpupt	610	24	to	to	TO
cord-285262-690kpupt	610	25	block	block	VB
cord-285262-690kpupt	610	26	necroptosis	necroptosis	NN
cord-285262-690kpupt	610	27	and	and	CC
cord-285262-690kpupt	610	28	inflammation	inflammation	NN
cord-285262-690kpupt	610	29	IRF-3	IRF-3	NNP
cord-285262-690kpupt	610	30	activation	activation	NN
cord-285262-690kpupt	610	31	by	by	IN
cord-285262-690kpupt	610	32	Sendai	Sendai	NNP
cord-285262-690kpupt	610	33	virus	virus	NN
cord-285262-690kpupt	610	34	infection	infection	NN
cord-285262-690kpupt	610	35	is	be	VBZ
cord-285262-690kpupt	610	36	required	require	VBN
cord-285262-690kpupt	610	37	for	for	IN
cord-285262-690kpupt	610	38	cellular	cellular	JJ
cord-285262-690kpupt	610	39	apoptosis	apoptosis	NN
cord-285262-690kpupt	610	40	and	and	CC
cord-285262-690kpupt	610	41	avoidance	avoidance	NN
cord-285262-690kpupt	610	42	of	of	IN
cord-285262-690kpupt	610	43	persistence	persistence	NN
cord-285262-690kpupt	610	44	AIM2	AIM2	NNP
cord-285262-690kpupt	610	45	/	/	SYM
cord-285262-690kpupt	610	46	ASC	ASC	NNP
cord-285262-690kpupt	610	47	triggers	trigger	VBZ
cord-285262-690kpupt	610	48	caspase-8-dependent	caspase-8-dependent	JJ
cord-285262-690kpupt	610	49	apoptosis	apoptosis	NN
cord-285262-690kpupt	610	50	in	in	IN
cord-285262-690kpupt	610	51	Francisella	Francisella	NNP
cord-285262-690kpupt	610	52	-	-	HYPH
cord-285262-690kpupt	610	53	infected	infect	VBN
cord-285262-690kpupt	610	54	caspase-1-deficient	caspase-1-deficient	NNP
cord-285262-690kpupt	610	55	macrophages	macrophage	NNS
cord-285262-690kpupt	610	56	Granzyme	Granzyme	NNP
cord-285262-690kpupt	610	57	B	b	NN
cord-285262-690kpupt	610	58	-	-	HYPH
cord-285262-690kpupt	610	59	mediated	mediate	VBN
cord-285262-690kpupt	610	60	apoptosis	apoptosis	NN
cord-285262-690kpupt	610	61	proceeds	proceed	VBZ
cord-285262-690kpupt	610	62	predominantly	predominantly	RB
cord-285262-690kpupt	610	63	through	through	IN
cord-285262-690kpupt	610	64	a	a	DT
cord-285262-690kpupt	610	65	Bcl-2-inhibitable	Bcl-2-inhibitable	NNP
cord-285262-690kpupt	610	66	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	610	67	pathway	pathway	NN
cord-285262-690kpupt	610	68	Shiga	Shiga	NNP
cord-285262-690kpupt	610	69	toxin	toxin	NN
cord-285262-690kpupt	610	70	/	/	SYM
cord-285262-690kpupt	610	71	lipopolysaccharide	lipopolysaccharide	NN
cord-285262-690kpupt	610	72	activates	activate	VBZ
cord-285262-690kpupt	610	73	caspase-4	caspase-4	NNP
cord-285262-690kpupt	610	74	and	and	CC
cord-285262-690kpupt	610	75	gasdermin	gasdermin	NNP
cord-285262-690kpupt	610	76	D	D	NNP
cord-285262-690kpupt	610	77	to	to	TO
cord-285262-690kpupt	610	78	trigger	trigger	VB
cord-285262-690kpupt	610	79	mitochondrial	mitochondrial	JJ
cord-285262-690kpupt	610	80	reactive	reactive	JJ
cord-285262-690kpupt	610	81	oxygen	oxygen	NN
cord-285262-690kpupt	610	82	species	specie	NNS
cord-285262-690kpupt	610	83	upstream	upstream	RB
cord-285262-690kpupt	610	84	of	of	IN
cord-285262-690kpupt	610	85	the	the	DT
cord-285262-690kpupt	610	86	NLRP3	nlrp3	XX
cord-285262-690kpupt	610	87	inflammasome	inflammasome	NNP
cord-285262-690kpupt	610	88	Phosphorylation	Phosphorylation	NNP
cord-285262-690kpupt	610	89	of	of	IN
cord-285262-690kpupt	610	90	NLRC4	NLRC4	NNP
cord-285262-690kpupt	610	91	is	be	VBZ
cord-285262-690kpupt	610	92	critical	critical	JJ
cord-285262-690kpupt	610	93	for	for	IN
cord-285262-690kpupt	610	94	inflammasome	inflammasome	NN
cord-285262-690kpupt	610	95	activation	activation	NN
cord-285262-690kpupt	610	96	Mechanisms	Mechanisms	NNPS
cord-285262-690kpupt	610	97	of	of	IN
cord-285262-690kpupt	610	98	inflammasome	inflammasome	NN
cord-285262-690kpupt	610	99	activation	activation	NN
cord-285262-690kpupt	610	100	by	by	IN
cord-285262-690kpupt	610	101	Vibrio	Vibrio	NNP
cord-285262-690kpupt	610	102	cholerae	cholerae	NN
cord-285262-690kpupt	611	1	secreted	secrete	VBN
cord-285262-690kpupt	611	2	toxins	toxin	NNS
cord-285262-690kpupt	611	3	vary	vary	VBP
cord-285262-690kpupt	611	4	with	with	IN
cord-285262-690kpupt	611	5	strain	strain	NN
cord-285262-690kpupt	611	6	biotype	biotype	NNP
cord-285262-690kpupt	611	7	Host	host	NN
cord-285262-690kpupt	611	8	cell	cell	NN
cord-285262-690kpupt	611	9	killing	kill	VBG
cord-285262-690kpupt	611	10	by	by	IN
cord-285262-690kpupt	611	11	the	the	DT
cord-285262-690kpupt	611	12	West	West	NNP
cord-285262-690kpupt	611	13	Nile	Nile	NNP
cord-285262-690kpupt	611	14	Virus	Virus	NNP
cord-285262-690kpupt	611	15	NS2B	NS2B	NNP
cord-285262-690kpupt	611	16	-	-	:
cord-285262-690kpupt	611	17	NS3	ns3	RB
cord-285262-690kpupt	611	18	proteolytic	proteolytic	JJ
cord-285262-690kpupt	611	19	complex	complex	NN
cord-285262-690kpupt	611	20	:	:	:
cord-285262-690kpupt	611	21	NS3	ns3	RB
cord-285262-690kpupt	611	22	alone	alone	RB
cord-285262-690kpupt	611	23	is	be	VBZ
cord-285262-690kpupt	611	24	sufficient	sufficient	JJ
cord-285262-690kpupt	611	25	to	to	TO
cord-285262-690kpupt	611	26	recruit	recruit	VB
cord-285262-690kpupt	611	27	caspase-8-based	caspase-8-based	JJ
cord-285262-690kpupt	611	28	apoptotic	apoptotic	JJ
cord-285262-690kpupt	611	29	pathway	pathway	NN
cord-285262-690kpupt	612	1	The	the	DT
cord-285262-690kpupt	612	2	AIM2	AIM2	NNP
cord-285262-690kpupt	612	3	inflammasome	inflammasome	NN
cord-285262-690kpupt	612	4	is	be	VBZ
cord-285262-690kpupt	612	5	essential	essential	JJ
cord-285262-690kpupt	612	6	for	for	IN
cord-285262-690kpupt	612	7	host	host	NN
cord-285262-690kpupt	612	8	defense	defense	NN
cord-285262-690kpupt	612	9	against	against	IN
cord-285262-690kpupt	612	10	cytosolic	cytosolic	JJ
cord-285262-690kpupt	612	11	bacteria	bacteria	NNS
cord-285262-690kpupt	612	12	and	and	CC
cord-285262-690kpupt	612	13	DNA	dna	NN
cord-285262-690kpupt	612	14	viruses	virus	NNS
cord-285262-690kpupt	613	1	The	the	DT
cord-285262-690kpupt	613	2	apoptosome	apoptosome	NN
cord-285262-690kpupt	613	3	:	:	:
cord-285262-690kpupt	613	4	signalling	signal	VBG
cord-285262-690kpupt	613	5	platform	platform	NN
cord-285262-690kpupt	613	6	of	of	IN
cord-285262-690kpupt	613	7	cell	cell	NN
cord-285262-690kpupt	613	8	death	death	NN
cord-285262-690kpupt	613	9	Type	type	NN
cord-285262-690kpupt	614	1	I	-PRON-	PRP
cord-285262-690kpupt	614	2	interferon	interferon	RB
cord-285262-690kpupt	614	3	induces	induce	VBZ
cord-285262-690kpupt	614	4	necroptosis	necroptosis	NNP
cord-285262-690kpupt	614	5	in	in	IN
cord-285262-690kpupt	614	6	macrophages	macrophage	NNS
cord-285262-690kpupt	614	7	during	during	IN
cord-285262-690kpupt	614	8	infection	infection	NN
cord-285262-690kpupt	614	9	with	with	IN
cord-285262-690kpupt	615	1	Salmonella	Salmonella	NNP
cord-285262-690kpupt	615	2	enterica	enterica	NNP
cord-285262-690kpupt	615	3	serovar	serovar	NNP
cord-285262-690kpupt	615	4	Typhimurium	Typhimurium	NNP
cord-285262-690kpupt	615	5	Cleavage	Cleavage	NNP
cord-285262-690kpupt	615	6	of	of	IN
cord-285262-690kpupt	615	7	DFNA5	dfna5	NN
cord-285262-690kpupt	615	8	by	by	IN
cord-285262-690kpupt	615	9	caspase-3	caspase-3	NNP
cord-285262-690kpupt	615	10	during	during	IN
cord-285262-690kpupt	615	11	apoptosis	apoptosis	NN
cord-285262-690kpupt	616	1	mediates	mediate	VBZ
cord-285262-690kpupt	616	2	progression	progression	NN
cord-285262-690kpupt	616	3	to	to	IN
cord-285262-690kpupt	616	4	secondary	secondary	JJ
cord-285262-690kpupt	616	5	necrotic	necrotic	JJ
cord-285262-690kpupt	616	6	/	/	SYM
cord-285262-690kpupt	616	7	pyroptotic	pyroptotic	JJ
cord-285262-690kpupt	616	8	cell	cell	NN
cord-285262-690kpupt	616	9	death	death	NN
cord-285262-690kpupt	616	10	Induction	Induction	NNP
cord-285262-690kpupt	616	11	of	of	IN
cord-285262-690kpupt	616	12	guanylate	guanylate	NNP
cord-285262-690kpupt	616	13	binding	bind	VBG
cord-285262-690kpupt	616	14	protein	protein	NN
cord-285262-690kpupt	616	15	5	5	CD
cord-285262-690kpupt	616	16	by	by	IN
cord-285262-690kpupt	616	17	gamma	gamma	NN
cord-285262-690kpupt	616	18	interferon	interferon	NN
cord-285262-690kpupt	616	19	increases	increase	VBZ
cord-285262-690kpupt	616	20	susceptibility	susceptibility	NN
cord-285262-690kpupt	616	21	to	to	IN
cord-285262-690kpupt	616	22	Salmonella	Salmonella	NNP
cord-285262-690kpupt	616	23	enterica	enterica	NNP
cord-285262-690kpupt	617	1	serovar	serovar	NNP
cord-285262-690kpupt	617	2	Typhimurium	Typhimurium	NNP
cord-285262-690kpupt	617	3	-	-	HYPH
cord-285262-690kpupt	617	4	induced	induce	VBN
cord-285262-690kpupt	617	5	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	617	6	in	in	IN
cord-285262-690kpupt	617	7	RAW	raw	JJ
cord-285262-690kpupt	617	8	264.7	264.7	CD
cord-285262-690kpupt	617	9	cells	cell	NNS
cord-285262-690kpupt	617	10	Casp8p41	casp8p41	NN
cord-285262-690kpupt	617	11	generated	generate	VBN
cord-285262-690kpupt	617	12	by	by	IN
cord-285262-690kpupt	617	13	HIV	HIV	NNP
cord-285262-690kpupt	617	14	protease	protease	NN
cord-285262-690kpupt	617	15	kills	kill	VBZ
cord-285262-690kpupt	617	16	CD4	CD4	NNP
cord-285262-690kpupt	617	17	T	T	NNP
cord-285262-690kpupt	617	18	cells	cell	NNS
cord-285262-690kpupt	617	19	through	through	IN
cord-285262-690kpupt	617	20	direct	direct	JJ
cord-285262-690kpupt	617	21	Bak	Bak	NNP
cord-285262-690kpupt	617	22	activation	activation	NN
cord-285262-690kpupt	617	23	Disruption	disruption	NN
cord-285262-690kpupt	617	24	of	of	IN
cord-285262-690kpupt	617	25	glycolytic	glycolytic	JJ
cord-285262-690kpupt	617	26	flux	flux	NN
cord-285262-690kpupt	617	27	is	be	VBZ
cord-285262-690kpupt	617	28	a	a	DT
cord-285262-690kpupt	617	29	signal	signal	NN
cord-285262-690kpupt	617	30	for	for	IN
cord-285262-690kpupt	617	31	inflammasome	inflammasome	NN
cord-285262-690kpupt	617	32	signaling	signal	VBG
cord-285262-690kpupt	617	33	and	and	CC
cord-285262-690kpupt	617	34	pyroptotic	pyroptotic	JJ
cord-285262-690kpupt	617	35	cell	cell	NN
cord-285262-690kpupt	617	36	death	death	NN
cord-285262-690kpupt	617	37	.	.	.
cord-285262-690kpupt	618	1	eLife	eLife	NNP
cord-285262-690kpupt	618	2	Caspase-8	Caspase-8	NNP
cord-285262-690kpupt	618	3	induces	induce	VBZ
cord-285262-690kpupt	618	4	cleavage	cleavage	NN
cord-285262-690kpupt	618	5	of	of	IN
cord-285262-690kpupt	618	6	gasdermin	gasdermin	NN
cord-285262-690kpupt	618	7	D	D	NNP
cord-285262-690kpupt	618	8	to	to	TO
cord-285262-690kpupt	618	9	elicit	elicit	VB
cord-285262-690kpupt	618	10	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	618	11	during	during	IN
cord-285262-690kpupt	618	12	Yersinia	Yersinia	NNP
cord-285262-690kpupt	618	13	infection	infection	NN
cord-285262-690kpupt	619	1	Listeria	Listeria	NNP
cord-285262-690kpupt	619	2	monocytogenes	monocytogene	NNS
cord-285262-690kpupt	619	3	triggers	trigger	VBZ
cord-285262-690kpupt	619	4	AIM2-mediated	AIM2-mediated	NNP
cord-285262-690kpupt	619	5	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	619	6	upon	upon	IN
cord-285262-690kpupt	619	7	infrequent	infrequent	JJ
cord-285262-690kpupt	619	8	bacteriolysis	bacteriolysis	NN
cord-285262-690kpupt	619	9	in	in	IN
cord-285262-690kpupt	619	10	the	the	DT
cord-285262-690kpupt	619	11	macrophage	macrophage	NN
cord-285262-690kpupt	619	12	cytosol	cytosol	NN
cord-285262-690kpupt	619	13	GSDMD	GSDMD	NNP
cord-285262-690kpupt	619	14	membrane	membrane	NN
cord-285262-690kpupt	619	15	pore	pore	NN
cord-285262-690kpupt	619	16	formation	formation	NN
cord-285262-690kpupt	619	17	constitutes	constitute	VBZ
cord-285262-690kpupt	619	18	the	the	DT
cord-285262-690kpupt	619	19	mechanism	mechanism	NN
cord-285262-690kpupt	619	20	of	of	IN
cord-285262-690kpupt	619	21	pyroptotic	pyroptotic	JJ
cord-285262-690kpupt	619	22	cell	cell	NN
cord-285262-690kpupt	619	23	death	death	NN
cord-285262-690kpupt	619	24	Release	Release	NNP
cord-285262-690kpupt	619	25	of	of	IN
cord-285262-690kpupt	619	26	chromatin	chromatin	NN
cord-285262-690kpupt	619	27	protein	protein	NN
cord-285262-690kpupt	619	28	HMGB1	hmgb1	RB
cord-285262-690kpupt	619	29	by	by	IN
cord-285262-690kpupt	619	30	necrotic	necrotic	JJ
cord-285262-690kpupt	619	31	cells	cell	NNS
cord-285262-690kpupt	619	32	triggers	trigger	VBZ
cord-285262-690kpupt	619	33	inflammation	inflammation	NN
cord-285262-690kpupt	620	1	Natural	natural	JJ
cord-285262-690kpupt	620	2	killer	killer	NN
cord-285262-690kpupt	620	3	and	and	CC
cord-285262-690kpupt	620	4	lymphokine	lymphokine	NN
cord-285262-690kpupt	620	5	-	-	HYPH
cord-285262-690kpupt	620	6	activated	activate	VBN
cord-285262-690kpupt	620	7	killer	killer	NN
cord-285262-690kpupt	620	8	cells	cell	NNS
cord-285262-690kpupt	620	9	require	require	VBP
cord-285262-690kpupt	620	10	granzyme	granzyme	NNS
cord-285262-690kpupt	620	11	B	B	NNP
cord-285262-690kpupt	620	12	for	for	IN
cord-285262-690kpupt	620	13	the	the	DT
cord-285262-690kpupt	620	14	rapid	rapid	JJ
cord-285262-690kpupt	620	15	induction	induction	NN
cord-285262-690kpupt	620	16	of	of	IN
cord-285262-690kpupt	620	17	apoptosis	apoptosis	NN
cord-285262-690kpupt	620	18	in	in	IN
cord-285262-690kpupt	620	19	susceptible	susceptible	JJ
cord-285262-690kpupt	620	20	target	target	NN
cord-285262-690kpupt	620	21	cells	cell	NNS
cord-285262-690kpupt	620	22	A	a	DT
cord-285262-690kpupt	620	23	cytomegalovirus	cytomegalovirus	NN
cord-285262-690kpupt	620	24	-	-	HYPH
cord-285262-690kpupt	620	25	encoded	encode	VBN
cord-285262-690kpupt	620	26	inhibitor	inhibitor	NN
cord-285262-690kpupt	620	27	of	of	IN
cord-285262-690kpupt	620	28	apoptosis	apoptosis	NN
cord-285262-690kpupt	620	29	that	that	WDT
cord-285262-690kpupt	620	30	suppresses	suppress	VBZ
cord-285262-690kpupt	620	31	caspase-8	caspase-8	NNP
cord-285262-690kpupt	620	32	activation	activation	NN
cord-285262-690kpupt	620	33	Pseudomonas	Pseudomonas	NNP
cord-285262-690kpupt	620	34	aeruginosa	aeruginosa	VBZ
cord-285262-690kpupt	620	35	quorumsensing	quorumsensing	NN
cord-285262-690kpupt	620	36	metabolite	metabolite	NN
cord-285262-690kpupt	620	37	induces	induce	VBZ
cord-285262-690kpupt	620	38	host	host	NN
cord-285262-690kpupt	620	39	immune	immune	JJ
cord-285262-690kpupt	620	40	cell	cell	NN
cord-285262-690kpupt	620	41	death	death	NN
cord-285262-690kpupt	620	42	through	through	IN
cord-285262-690kpupt	620	43	cell	cell	NN
cord-285262-690kpupt	620	44	surface	surface	NN
cord-285262-690kpupt	620	45	lipid	lipid	NN
cord-285262-690kpupt	620	46	domain	domain	NN
cord-285262-690kpupt	620	47	dissolution	dissolution	NN
cord-285262-690kpupt	620	48	Murine	Murine	NNP
cord-285262-690kpupt	620	49	cytomegalovirus	cytomegalovirus	NN
cord-285262-690kpupt	620	50	IE3-dependent	ie3-dependent	NN
cord-285262-690kpupt	620	51	transcription	transcription	NN
cord-285262-690kpupt	620	52	is	be	VBZ
cord-285262-690kpupt	620	53	required	require	VBN
cord-285262-690kpupt	620	54	for	for	IN
cord-285262-690kpupt	620	55	DAI	DAI	NNP
cord-285262-690kpupt	620	56	/	/	SYM
cord-285262-690kpupt	620	57	ZBP1-mediated	zbp1-mediate	VBN
cord-285262-690kpupt	620	58	necroptosis	necroptosis	NN
cord-285262-690kpupt	620	59	Is	be	VBZ
cord-285262-690kpupt	620	60	receptor	receptor	NN
cord-285262-690kpupt	620	61	-	-	HYPH
cord-285262-690kpupt	620	62	interacting	interact	VBG
cord-285262-690kpupt	620	63	protein	protein	NN
cord-285262-690kpupt	620	64	kinase	kinase	VBD
cord-285262-690kpupt	620	65	3	3	CD
cord-285262-690kpupt	620	66	a	a	DT
cord-285262-690kpupt	620	67	viable	viable	JJ
cord-285262-690kpupt	620	68	therapeutic	therapeutic	JJ
cord-285262-690kpupt	620	69	target	target	NN
cord-285262-690kpupt	620	70	for	for	IN
cord-285262-690kpupt	620	71	Mycobacterium	Mycobacterium	NNP
cord-285262-690kpupt	620	72	tuberculosis	tuberculosis	NN
cord-285262-690kpupt	620	73	infection	infection	NN
cord-285262-690kpupt	620	74	?	?	.
cord-285262-690kpupt	621	1	Mixed	mixed	JJ
cord-285262-690kpupt	621	2	lineage	lineage	NN
cord-285262-690kpupt	621	3	kinase	kinase	VBZ
cord-285262-690kpupt	621	4	domain	domain	NN
cord-285262-690kpupt	621	5	-	-	HYPH
cord-285262-690kpupt	621	6	like	like	JJ
cord-285262-690kpupt	621	7	protein	protein	NN
cord-285262-690kpupt	621	8	mediates	mediate	VBZ
cord-285262-690kpupt	621	9	necrosis	necrosis	NN
cord-285262-690kpupt	621	10	signaling	signal	VBG
cord-285262-690kpupt	621	11	downstream	downstream	NN
cord-285262-690kpupt	621	12	of	of	IN
cord-285262-690kpupt	621	13	RIP3	RIP3	NNP
cord-285262-690kpupt	621	14	kinase	kinase	VBD
cord-285262-690kpupt	621	15	Cyclic	Cyclic	NNP
cord-285262-690kpupt	621	16	GMP	GMP	NNP
cord-285262-690kpupt	621	17	-	-	HYPH
cord-285262-690kpupt	621	18	AMP	AMP	NNP
cord-285262-690kpupt	621	19	synthase	synthase	NN
cord-285262-690kpupt	621	20	is	be	VBZ
cord-285262-690kpupt	621	21	a	a	DT
cord-285262-690kpupt	621	22	cytosolic	cytosolic	JJ
cord-285262-690kpupt	621	23	DNA	dna	NN
cord-285262-690kpupt	621	24	sensor	sensor	NN
cord-285262-690kpupt	621	25	that	that	WDT
cord-285262-690kpupt	621	26	activates	activate	VBZ
cord-285262-690kpupt	621	27	the	the	DT
cord-285262-690kpupt	621	28	type	type	NN
cord-285262-690kpupt	621	29	I	-PRON-	PRP
cord-285262-690kpupt	621	30	interferon	interferon	VBD
cord-285262-690kpupt	621	31	pathway	pathway	NN
cord-285262-690kpupt	621	32	Differential	differential	JJ
cord-285262-690kpupt	621	33	regulation	regulation	NN
cord-285262-690kpupt	621	34	of	of	IN
cord-285262-690kpupt	621	35	caspase-1	caspase-1	NNP
cord-285262-690kpupt	621	36	activation	activation	NN
cord-285262-690kpupt	621	37	,	,	,
cord-285262-690kpupt	621	38	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	621	39	,	,	,
cord-285262-690kpupt	621	40	and	and	CC
cord-285262-690kpupt	621	41	autophagy	autophagy	NN
cord-285262-690kpupt	621	42	via	via	IN
cord-285262-690kpupt	621	43	Ipaf	Ipaf	NNP
cord-285262-690kpupt	621	44	and	and	CC
cord-285262-690kpupt	621	45	ASC	ASC	NNP
cord-285262-690kpupt	621	46	in	in	IN
cord-285262-690kpupt	621	47	Shigella	Shigella	NNP
cord-285262-690kpupt	621	48	-	-	HYPH
cord-285262-690kpupt	621	49	infected	infect	VBN
cord-285262-690kpupt	621	50	macrophages	macrophage	NNS
cord-285262-690kpupt	621	51	Shigella	Shigella	NNP
cord-285262-690kpupt	622	1	type	type	NN
cord-285262-690kpupt	622	2	III	III	NNP
cord-285262-690kpupt	622	3	secretion	secretion	NN
cord-285262-690kpupt	622	4	protein	protein	NN
cord-285262-690kpupt	622	5	MxiI	MxiI	NNP
cord-285262-690kpupt	622	6	is	be	VBZ
cord-285262-690kpupt	622	7	recognized	recognize	VBN
cord-285262-690kpupt	622	8	by	by	IN
cord-285262-690kpupt	622	9	Naip2	Naip2	NNP
cord-285262-690kpupt	622	10	to	to	TO
cord-285262-690kpupt	622	11	induce	induce	VB
cord-285262-690kpupt	622	12	Nlrc4	Nlrc4	NNP
cord-285262-690kpupt	622	13	inflammasome	inflammasome	NNP
cord-285262-690kpupt	622	14	activation	activation	NN
cord-285262-690kpupt	622	15	independently	independently	RB
cord-285262-690kpupt	622	16	of	of	IN
cord-285262-690kpupt	622	17	Pkcδ	Pkcδ	NNP
cord-285262-690kpupt	622	18	Mitochondria	Mitochondria	NNP
cord-285262-690kpupt	622	19	and	and	CC
cord-285262-690kpupt	622	20	cell	cell	NN
cord-285262-690kpupt	622	21	death	death	NN
cord-285262-690kpupt	622	22	:	:	:
cord-285262-690kpupt	622	23	outer	outer	JJ
cord-285262-690kpupt	622	24	membrane	membrane	NN
cord-285262-690kpupt	622	25	permeabilization	permeabilization	NN
cord-285262-690kpupt	622	26	and	and	CC
cord-285262-690kpupt	622	27	beyond	beyond	IN
cord-285262-690kpupt	622	28	Dengue	Dengue	NNP
cord-285262-690kpupt	622	29	virus	virus	NN
cord-285262-690kpupt	622	30	-	-	HYPH
cord-285262-690kpupt	622	31	infected	infect	VBN
cord-285262-690kpupt	622	32	human	human	JJ
cord-285262-690kpupt	622	33	monocytes	monocyte	NNS
cord-285262-690kpupt	622	34	trigger	trigger	NN
cord-285262-690kpupt	622	35	late	late	JJ
cord-285262-690kpupt	622	36	activation	activation	NN
cord-285262-690kpupt	622	37	of	of	IN
cord-285262-690kpupt	622	38	caspase-1	caspase-1	NNP
cord-285262-690kpupt	622	39	,	,	,
cord-285262-690kpupt	622	40	which	which	WDT
cord-285262-690kpupt	622	41	mediates	mediate	VBZ
cord-285262-690kpupt	622	42	pro	pro	JJ
cord-285262-690kpupt	622	43	-	-	JJ
cord-285262-690kpupt	622	44	inflammatory	inflammatory	JJ
cord-285262-690kpupt	622	45	IL-1β	IL-1β	JJR
cord-285262-690kpupt	622	46	secretion	secretion	NN
cord-285262-690kpupt	622	47	and	and	CC
cord-285262-690kpupt	622	48	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	623	1	The	the	DT
cord-285262-690kpupt	623	2	Ripoptosome	Ripoptosome	NNP
cord-285262-690kpupt	623	3	,	,	,
cord-285262-690kpupt	623	4	a	a	DT
cord-285262-690kpupt	623	5	signaling	signal	VBG
cord-285262-690kpupt	623	6	platform	platform	NN
cord-285262-690kpupt	623	7	that	that	WDT
cord-285262-690kpupt	623	8	assembles	assemble	VBZ
cord-285262-690kpupt	623	9	in	in	IN
cord-285262-690kpupt	623	10	response	response	NN
cord-285262-690kpupt	623	11	to	to	IN
cord-285262-690kpupt	623	12	genotoxic	genotoxic	JJ
cord-285262-690kpupt	623	13	stress	stress	NN
cord-285262-690kpupt	623	14	and	and	CC
cord-285262-690kpupt	623	15	loss	loss	NN
cord-285262-690kpupt	623	16	of	of	IN
cord-285262-690kpupt	623	17	IAPs	IAPs	NNP
cord-285262-690kpupt	623	18	Yama	Yama	NNP
cord-285262-690kpupt	623	19	/	/	SYM
cord-285262-690kpupt	623	20	CPP32β	CPP32β	NNP
cord-285262-690kpupt	623	21	,	,	,
cord-285262-690kpupt	623	22	a	a	DT
cord-285262-690kpupt	623	23	mammalian	mammalian	JJ
cord-285262-690kpupt	623	24	homolog	homolog	NN
cord-285262-690kpupt	623	25	of	of	IN
cord-285262-690kpupt	623	26	CED-3	CED-3	NNP
cord-285262-690kpupt	623	27	,	,	,
cord-285262-690kpupt	623	28	is	be	VBZ
cord-285262-690kpupt	623	29	a	a	DT
cord-285262-690kpupt	623	30	CrmA	crma	NN
cord-285262-690kpupt	623	31	-	-	HYPH
cord-285262-690kpupt	623	32	inhibitable	inhibitable	JJ
cord-285262-690kpupt	623	33	protease	protease	NN
cord-285262-690kpupt	623	34	that	that	WDT
cord-285262-690kpupt	623	35	cleaves	cleave	VBZ
cord-285262-690kpupt	623	36	the	the	DT
cord-285262-690kpupt	623	37	death	death	NN
cord-285262-690kpupt	623	38	substrate	substrate	NN
cord-285262-690kpupt	623	39	poly(ADPribose	poly(ADPribose	VBD
cord-285262-690kpupt	623	40	)	)	-RRB-
cord-285262-690kpupt	624	1	polymerase	polymerase	NNP
cord-285262-690kpupt	624	2	DAI	DAI	NNP
cord-285262-690kpupt	624	3	senses	sense	VBZ
cord-285262-690kpupt	624	4	influenza	influenza	NN
cord-285262-690kpupt	624	5	A	a	DT
cord-285262-690kpupt	624	6	virus	virus	NN
cord-285262-690kpupt	624	7	genomic	genomic	JJ
cord-285262-690kpupt	624	8	RNA	RNA	NNP
cord-285262-690kpupt	624	9	and	and	CC
cord-285262-690kpupt	624	10	activates	activate	VBZ
cord-285262-690kpupt	624	11	RIPK3-dependent	ripk3-dependent	NN
cord-285262-690kpupt	624	12	cell	cell	NN
cord-285262-690kpupt	624	13	death	death	NN
cord-285262-690kpupt	624	14	Viral	Viral	NNP
cord-285262-690kpupt	624	15	FLICE	FLICE	NNP
cord-285262-690kpupt	624	16	-	-	HYPH
cord-285262-690kpupt	624	17	inhibitory	inhibitory	JJ
cord-285262-690kpupt	624	18	proteins	protein	NNS
cord-285262-690kpupt	624	19	(	(	-LRB-
cord-285262-690kpupt	624	20	FLIPs	flip	NNS
cord-285262-690kpupt	624	21	)	)	-RRB-
cord-285262-690kpupt	625	1	prevent	prevent	JJ
cord-285262-690kpupt	625	2	apoptosis	apoptosis	NN
cord-285262-690kpupt	625	3	induced	induce	VBN
cord-285262-690kpupt	625	4	by	by	IN
cord-285262-690kpupt	625	5	death	death	NN
cord-285262-690kpupt	625	6	receptors	receptor	NNS
cord-285262-690kpupt	625	7	Virus	virus	NN
cord-285262-690kpupt	625	8	inhibition	inhibition	NN
cord-285262-690kpupt	625	9	of	of	IN
cord-285262-690kpupt	625	10	RIP3-dependent	rip3-dependent	JJ
cord-285262-690kpupt	625	11	necrosis	necrosis	NN
cord-285262-690kpupt	625	12	DAI	DAI	NNP
cord-285262-690kpupt	625	13	/	/	SYM
cord-285262-690kpupt	625	14	ZBP1	ZBP1	NNP
cord-285262-690kpupt	625	15	/	/	SYM
cord-285262-690kpupt	625	16	DLM-1	DLM-1	NNP
cord-285262-690kpupt	625	17	complexes	complex	NNS
cord-285262-690kpupt	625	18	with	with	IN
cord-285262-690kpupt	625	19	RIP3	RIP3	NNS
cord-285262-690kpupt	625	20	to	to	TO
cord-285262-690kpupt	625	21	mediate	mediate	VB
cord-285262-690kpupt	625	22	virus	virus	NN
cord-285262-690kpupt	625	23	-	-	HYPH
cord-285262-690kpupt	625	24	induced	induce	VBN
cord-285262-690kpupt	625	25	programmed	program	VBN
cord-285262-690kpupt	625	26	necrosis	necrosis	NN
cord-285262-690kpupt	625	27	that	that	WDT
cord-285262-690kpupt	625	28	is	be	VBZ
cord-285262-690kpupt	625	29	targeted	target	VBN
cord-285262-690kpupt	625	30	by	by	IN
cord-285262-690kpupt	625	31	murine	murine	JJ
cord-285262-690kpupt	625	32	cytomegalovirus	cytomegalovirus	NN
cord-285262-690kpupt	625	33	vIRA	vira	IN
cord-285262-690kpupt	625	34	Group	Group	NNP
cord-285262-690kpupt	625	35	A	A	NNP
cord-285262-690kpupt	625	36	streptococcal	streptococcal	JJ
cord-285262-690kpupt	625	37	M	M	NNP
cord-285262-690kpupt	625	38	protein	protein	NN
cord-285262-690kpupt	626	1	activates	activate	VBZ
cord-285262-690kpupt	626	2	the	the	DT
cord-285262-690kpupt	626	3	NLRP3	nlrp3	XX
cord-285262-690kpupt	626	4	inflammasome	inflammasome	NNP
cord-285262-690kpupt	626	5	Caspases	Caspases	NNP
cord-285262-690kpupt	626	6	in	in	IN
cord-285262-690kpupt	626	7	cell	cell	NN
cord-285262-690kpupt	626	8	death	death	NN
cord-285262-690kpupt	626	9	,	,	,
cord-285262-690kpupt	627	1	inflammation	inflammation	NN
cord-285262-690kpupt	627	2	,	,	,
cord-285262-690kpupt	627	3	and	and	CC
cord-285262-690kpupt	627	4	disease	disease	NN
cord-285262-690kpupt	627	5	Un)expected	un)expecte	VBN
cord-285262-690kpupt	627	6	roles	role	NNS
cord-285262-690kpupt	627	7	of	of	IN
cord-285262-690kpupt	627	8	c	c	NN
cord-285262-690kpupt	627	9	-	-	HYPH
cord-285262-690kpupt	627	10	IAPs	IAPs	NNP
cord-285262-690kpupt	627	11	in	in	IN
cord-285262-690kpupt	627	12	apoptotic	apoptotic	JJ
cord-285262-690kpupt	627	13	and	and	CC
cord-285262-690kpupt	627	14	NFkappaB	NFkappaB	NNP
cord-285262-690kpupt	627	15	signaling	signal	VBG
cord-285262-690kpupt	627	16	pathways	pathway	NNS
cord-285262-690kpupt	628	1	Intracellular	intracellular	JJ
cord-285262-690kpupt	628	2	regulation	regulation	NN
cord-285262-690kpupt	628	3	of	of	IN
cord-285262-690kpupt	628	4	TNF	TNF	NNP
cord-285262-690kpupt	628	5	activity	activity	NN
cord-285262-690kpupt	628	6	in	in	IN
cord-285262-690kpupt	628	7	health	health	NN
cord-285262-690kpupt	628	8	and	and	CC
cord-285262-690kpupt	628	9	disease	disease	NN
cord-285262-690kpupt	629	1	Dual	dual	JJ
cord-285262-690kpupt	629	2	signaling	signaling	NN
cord-285262-690kpupt	629	3	of	of	IN
cord-285262-690kpupt	629	4	the	the	DT
cord-285262-690kpupt	629	5	Fas	Fas	NNP
cord-285262-690kpupt	629	6	receptor	receptor	NN
cord-285262-690kpupt	629	7	:	:	:
cord-285262-690kpupt	629	8	initiation	initiation	NN
cord-285262-690kpupt	629	9	of	of	IN
cord-285262-690kpupt	629	10	both	both	DT
cord-285262-690kpupt	629	11	apoptotic	apoptotic	JJ
cord-285262-690kpupt	629	12	and	and	CC
cord-285262-690kpupt	629	13	necrotic	necrotic	JJ
cord-285262-690kpupt	629	14	cell	cell	NN
cord-285262-690kpupt	629	15	death	death	NN
cord-285262-690kpupt	629	16	pathways	pathway	NNS
cord-285262-690kpupt	629	17	Infection	infection	NN
cord-285262-690kpupt	629	18	of	of	IN
cord-285262-690kpupt	629	19	epithelial	epithelial	JJ
cord-285262-690kpupt	629	20	cells	cell	NNS
cord-285262-690kpupt	629	21	with	with	IN
cord-285262-690kpupt	629	22	Chlamydia	Chlamydia	NNP
cord-285262-690kpupt	629	23	trachomatis	trachomatis	NN
cord-285262-690kpupt	629	24	inhibits	inhibit	VBZ
cord-285262-690kpupt	629	25	TNF	tnf	NN
cord-285262-690kpupt	629	26	-	-	HYPH
cord-285262-690kpupt	629	27	induced	induce	VBN
cord-285262-690kpupt	629	28	apoptosis	apoptosis	NN
cord-285262-690kpupt	629	29	at	at	IN
cord-285262-690kpupt	629	30	the	the	DT
cord-285262-690kpupt	629	31	level	level	NN
cord-285262-690kpupt	629	32	of	of	IN
cord-285262-690kpupt	629	33	receptor	receptor	NN
cord-285262-690kpupt	629	34	internalization	internalization	NN
cord-285262-690kpupt	629	35	while	while	IN
cord-285262-690kpupt	629	36	leaving	leave	VBG
cord-285262-690kpupt	629	37	non	non	JJ
cord-285262-690kpupt	629	38	-	-	JJ
cord-285262-690kpupt	629	39	apoptotic	apoptotic	JJ
cord-285262-690kpupt	629	40	TNF	tnf	NN
cord-285262-690kpupt	629	41	-	-	HYPH
cord-285262-690kpupt	629	42	signalling	signal	VBG
cord-285262-690kpupt	629	43	intact	intact	JJ
cord-285262-690kpupt	629	44	Novel	novel	JJ
cord-285262-690kpupt	629	45	pandemic	pandemic	NN
cord-285262-690kpupt	630	1	influenza	influenza	NNP
cord-285262-690kpupt	630	2	A	A	NNP
cord-285262-690kpupt	630	3	(	(	-LRB-
cord-285262-690kpupt	630	4	H1N1	H1N1	NNP
cord-285262-690kpupt	630	5	)	)	-RRB-
cord-285262-690kpupt	630	6	virus	virus	NN
cord-285262-690kpupt	630	7	infection	infection	NN
cord-285262-690kpupt	630	8	modulates	modulate	VBZ
cord-285262-690kpupt	630	9	apoptotic	apoptotic	JJ
cord-285262-690kpupt	630	10	pathways	pathway	NNS
cord-285262-690kpupt	630	11	that	that	WDT
cord-285262-690kpupt	630	12	impact	impact	VBP
cord-285262-690kpupt	630	13	its	-PRON-	PRP$
cord-285262-690kpupt	630	14	replication	replication	NN
cord-285262-690kpupt	630	15	in	in	IN
cord-285262-690kpupt	630	16	A549	a549	JJ
cord-285262-690kpupt	630	17	cells	cell	NNS
cord-285262-690kpupt	631	1	Cathepsin	Cathepsin	NNP
cord-285262-690kpupt	631	2	B	B	NNP
cord-285262-690kpupt	631	3	aggravates	aggravate	VBZ
cord-285262-690kpupt	631	4	coxsackievirus	coxsackievirus	NNP
cord-285262-690kpupt	631	5	B3-induced	b3-induce	VBN
cord-285262-690kpupt	631	6	myocarditis	myocarditis	RB
cord-285262-690kpupt	631	7	through	through	IN
cord-285262-690kpupt	631	8	activating	activate	VBG
cord-285262-690kpupt	631	9	the	the	DT
cord-285262-690kpupt	631	10	inflammasome	inflammasome	NN
cord-285262-690kpupt	631	11	and	and	CC
cord-285262-690kpupt	631	12	promoting	promote	VBG
cord-285262-690kpupt	631	13	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	631	14	Gasdermin	Gasdermin	NNP
cord-285262-690kpupt	631	15	D	D	NNP
cord-285262-690kpupt	631	16	protects	protect	VBZ
cord-285262-690kpupt	631	17	from	from	IN
cord-285262-690kpupt	631	18	melioidosis	melioidosis	NNP
cord-285262-690kpupt	631	19	through	through	IN
cord-285262-690kpupt	631	20	pyroptosis	pyroptosis	NNP
cord-285262-690kpupt	631	21	and	and	CC
cord-285262-690kpupt	631	22	direct	direct	JJ
cord-285262-690kpupt	631	23	killing	killing	NN
cord-285262-690kpupt	631	24	of	of	IN
cord-285262-690kpupt	631	25	bacteria	bacteria	NNS
cord-285262-690kpupt	631	26	Influenza	Influenza	NNP
cord-285262-690kpupt	631	27	virus	virus	NN
cord-285262-690kpupt	631	28	infection	infection	NN
cord-285262-690kpupt	631	29	induces	induce	VBZ
cord-285262-690kpupt	631	30	ZBP1	ZBP1	NNP
cord-285262-690kpupt	631	31	expression	expression	NN
cord-285262-690kpupt	631	32	and	and	CC
cord-285262-690kpupt	631	33	necroptosis	necroptosis	NN
cord-285262-690kpupt	631	34	in	in	IN
cord-285262-690kpupt	631	35	mouse	mouse	NN
cord-285262-690kpupt	631	36	lungs	lung	NNS
cord-285262-690kpupt	632	1	Multiple	multiple	JJ
cord-285262-690kpupt	632	2	Nodlike	Nodlike	NNP
cord-285262-690kpupt	632	3	receptors	receptor	NNS
cord-285262-690kpupt	632	4	activate	activate	VBP
cord-285262-690kpupt	632	5	caspase	caspase	NN
cord-285262-690kpupt	632	6	1	1	CD
cord-285262-690kpupt	632	7	during	during	IN
cord-285262-690kpupt	632	8	Listeria	Listeria	NNP
cord-285262-690kpupt	632	9	monocytogenes	monocytogene	VBZ
cord-285262-690kpupt	632	10	infection	infection	NN
cord-285262-690kpupt	633	1	Proapoptotic	Proapoptotic	NNP
cord-285262-690kpupt	633	2	signalling	signal	VBG
cord-285262-690kpupt	633	3	through	through	IN
cord-285262-690kpupt	634	1	Toll	toll	NN
cord-285262-690kpupt	634	2	-	-	HYPH
cord-285262-690kpupt	634	3	like	like	JJ
cord-285262-690kpupt	634	4	receptor-3	receptor-3	NNP
cord-285262-690kpupt	634	5	involves	involve	VBZ
cord-285262-690kpupt	634	6	TRIF	trif	NN
cord-285262-690kpupt	634	7	-	-	HYPH
cord-285262-690kpupt	634	8	dependent	dependent	JJ
cord-285262-690kpupt	634	9	activation	activation	NN
cord-285262-690kpupt	634	10	of	of	IN
cord-285262-690kpupt	634	11	caspase-8	caspase-8	NNP
cord-285262-690kpupt	634	12	and	and	CC
cord-285262-690kpupt	634	13	is	be	VBZ
cord-285262-690kpupt	634	14	under	under	IN
cord-285262-690kpupt	634	15	the	the	DT
cord-285262-690kpupt	634	16	control	control	NN
cord-285262-690kpupt	634	17	of	of	IN
cord-285262-690kpupt	634	18	inhibitor	inhibitor	NN
cord-285262-690kpupt	634	19	of	of	IN
cord-285262-690kpupt	634	20	apoptosis	apoptosis	NN
cord-285262-690kpupt	634	21	proteins	protein	NNS
cord-285262-690kpupt	634	22	in	in	IN
cord-285262-690kpupt	634	23	melanoma	melanoma	NN
cord-285262-690kpupt	634	24	cells	cell	NNS
cord-285262-690kpupt	635	1	IL-24	IL-24	NNP
cord-285262-690kpupt	636	1	sensitizes	sensitize	VBZ
cord-285262-690kpupt	636	2	tumor	tumor	NN
cord-285262-690kpupt	636	3	cells	cell	NNS
cord-285262-690kpupt	636	4	to	to	IN
cord-285262-690kpupt	636	5	TLR3-mediated	tlr3-mediated	JJ
cord-285262-690kpupt	636	6	apoptosis	apoptosis	NN
cord-285262-690kpupt	636	7	Caspase-8	Caspase-8	NNP
cord-285262-690kpupt	636	8	and	and	CC
cord-285262-690kpupt	636	9	RIP	rip	NN
cord-285262-690kpupt	636	10	kinases	kinase	NNS
cord-285262-690kpupt	636	11	regulate	regulate	VBP
cord-285262-690kpupt	636	12	bacteria	bacteria	NNS
cord-285262-690kpupt	636	13	-	-	HYPH
cord-285262-690kpupt	636	14	induced	induce	VBN
cord-285262-690kpupt	636	15	innate	innate	JJ
cord-285262-690kpupt	636	16	immune	immune	JJ
cord-285262-690kpupt	636	17	responses	response	NNS
cord-285262-690kpupt	636	18	and	and	CC
cord-285262-690kpupt	636	19	cell	cell	NN
cord-285262-690kpupt	636	20	death	death	NN
cord-285262-690kpupt	637	1	Apoptotic	apoptotic	JJ
cord-285262-690kpupt	637	2	caspases	caspase	NNS
cord-285262-690kpupt	637	3	suppress	suppress	VBP
cord-285262-690kpupt	637	4	mtDNA	mtdna	NN
cord-285262-690kpupt	637	5	-	-	HYPH
cord-285262-690kpupt	637	6	induced	induce	VBN
cord-285262-690kpupt	637	7	STING	sting	NN
cord-285262-690kpupt	637	8	-	-	HYPH
cord-285262-690kpupt	637	9	mediated	mediate	VBN
cord-285262-690kpupt	637	10	type	type	NN
cord-285262-690kpupt	638	1	I	-PRON-	PRP
cord-285262-690kpupt	638	2	IFN	IFN	NNP
cord-285262-690kpupt	638	3	production	production	NN
cord-285262-690kpupt	638	4	Death	death	NN
cord-285262-690kpupt	638	5	receptor	receptor	NN
cord-285262-690kpupt	638	6	signal	signal	NN
cord-285262-690kpupt	638	7	transducers	transducer	NNS
cord-285262-690kpupt	638	8	:	:	:
cord-285262-690kpupt	638	9	nodes	node	NNS
cord-285262-690kpupt	638	10	of	of	IN
cord-285262-690kpupt	638	11	coordination	coordination	NN
cord-285262-690kpupt	638	12	in	in	IN
cord-285262-690kpupt	638	13	immune	immune	JJ
cord-285262-690kpupt	638	14	signaling	signaling	NN
cord-285262-690kpupt	638	15	networks	network	NNS
cord-285262-690kpupt	639	1	CLEC5A	CLEC5A	NNP
cord-285262-690kpupt	639	2	is	be	VBZ
cord-285262-690kpupt	639	3	critical	critical	JJ
cord-285262-690kpupt	639	4	for	for	IN
cord-285262-690kpupt	639	5	dengue	dengue	NN
cord-285262-690kpupt	639	6	virus	virus	NN
cord-285262-690kpupt	639	7	-	-	HYPH
cord-285262-690kpupt	639	8	induced	induce	VBN
cord-285262-690kpupt	639	9	inflammasome	inflammasome	NN
cord-285262-690kpupt	639	10	activation	activation	NN
cord-285262-690kpupt	639	11	in	in	IN
cord-285262-690kpupt	639	12	human	human	JJ
cord-285262-690kpupt	639	13	macrophages	macrophage	NNS
cord-285262-690kpupt	639	14	Structural	structural	JJ
cord-285262-690kpupt	639	15	basis	basis	NN
cord-285262-690kpupt	639	16	of	of	IN
cord-285262-690kpupt	639	17	RIP1	RIP1	NNP
cord-285262-690kpupt	639	18	inhibition	inhibition	NN
cord-285262-690kpupt	639	19	by	by	IN
cord-285262-690kpupt	639	20	necrostatins	necrostatins	NNP
cord-285262-690kpupt	639	21	Role	role	NN
cord-285262-690kpupt	639	22	of	of	IN
cord-285262-690kpupt	639	23	adaptor	adaptor	NN
cord-285262-690kpupt	639	24	TRIF	TRIF	NNP
cord-285262-690kpupt	639	25	in	in	IN
cord-285262-690kpupt	639	26	the	the	DT
cord-285262-690kpupt	639	27	MyD88-independent	MyD88-independent	NNP
cord-285262-690kpupt	639	28	Toll	Toll	NNP
cord-285262-690kpupt	639	29	-	-	HYPH
cord-285262-690kpupt	639	30	like	like	JJ
cord-285262-690kpupt	639	31	receptor	receptor	NN
cord-285262-690kpupt	639	32	signaling	signal	VBG
cord-285262-690kpupt	639	33	pathway	pathway	NN
cord-285262-690kpupt	639	34	Human	Human	NNP
cord-285262-690kpupt	639	35	NAIP	NAIP	NNP
cord-285262-690kpupt	639	36	and	and	CC
cord-285262-690kpupt	639	37	mouse	mouse	NN
cord-285262-690kpupt	639	38	NAIP1	NAIP1	MD
cord-285262-690kpupt	639	39	recognize	recognize	VBP
cord-285262-690kpupt	639	40	bacterial	bacterial	JJ
cord-285262-690kpupt	639	41	type	type	NN
cord-285262-690kpupt	639	42	III	iii	CD
cord-285262-690kpupt	639	43	secretion	secretion	NN
cord-285262-690kpupt	639	44	needle	needle	NN
cord-285262-690kpupt	639	45	protein	protein	NN
cord-285262-690kpupt	639	46	for	for	IN
cord-285262-690kpupt	639	47	inflammasome	inflammasome	NNP
cord-285262-690kpupt	639	48	activation	activation	NNP
cord-285262-690kpupt	639	49	RIPK1	RIPK1	NNP
cord-285262-690kpupt	639	50	and	and	CC
cord-285262-690kpupt	640	1	NF	NF	NNP
cord-285262-690kpupt	640	2	-	-	HYPH
cord-285262-690kpupt	640	3	κB	κB	NNP
cord-285262-690kpupt	640	4	signaling	signal	VBG
cord-285262-690kpupt	640	5	in	in	IN
cord-285262-690kpupt	640	6	dying	die	VBG
cord-285262-690kpupt	640	7	cells	cell	NNS
cord-285262-690kpupt	640	8	determines	determine	VBZ
cord-285262-690kpupt	640	9	cross	cross	NN
cord-285262-690kpupt	640	10	-	-	JJ
cord-285262-690kpupt	640	11	priming	priming	NN
cord-285262-690kpupt	640	12	of	of	IN
cord-285262-690kpupt	640	13	CD8	CD8	NNP
cord-285262-690kpupt	640	14	+	+	CC
cord-285262-690kpupt	640	15	T	T	NNP
cord-285262-690kpupt	640	16	cells	cell	NNS
cord-285262-690kpupt	640	17	AIM2	AIM2	NNP
cord-285262-690kpupt	640	18	inflammasome	inflammasome	NN
cord-285262-690kpupt	640	19	-	-	HYPH
cord-285262-690kpupt	640	20	mediated	mediate	VBN
cord-285262-690kpupt	640	21	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	640	22	in	in	IN
cord-285262-690kpupt	640	23	enterovirus	enterovirus	JJ
cord-285262-690kpupt	640	24	A71-infected	A71-infected	NNP
cord-285262-690kpupt	640	25	neuronal	neuronal	JJ
cord-285262-690kpupt	640	26	cells	cell	NNS
cord-285262-690kpupt	640	27	restricts	restrict	VBZ
cord-285262-690kpupt	640	28	viral	viral	JJ
cord-285262-690kpupt	640	29	replication	replication	NN
cord-285262-690kpupt	641	1	Vaccinia	vaccinia	NN
cord-285262-690kpupt	641	2	virus	virus	NN
cord-285262-690kpupt	641	3	protein	protein	NN
cord-285262-690kpupt	641	4	F1L	f1l	RB
cord-285262-690kpupt	641	5	is	be	VBZ
cord-285262-690kpupt	641	6	a	a	DT
cord-285262-690kpupt	641	7	caspase-9	caspase-9	NNP
cord-285262-690kpupt	641	8	inhibitor	inhibitor	NN
cord-285262-690kpupt	641	9	Involvement	Involvement	NNP
cord-285262-690kpupt	641	10	of	of	IN
cord-285262-690kpupt	641	11	P2X4	P2X4	NNP
cord-285262-690kpupt	641	12	receptor	receptor	NN
cord-285262-690kpupt	641	13	in	in	IN
cord-285262-690kpupt	641	14	gp120-induced	gp120-induced	NNP
cord-285262-690kpupt	641	15	pyroptosis	pyroptosis	NN
cord-285262-690kpupt	641	16	in	in	IN
cord-285262-690kpupt	641	17	dorsal	dorsal	JJ
cord-285262-690kpupt	641	18	root	root	NN
cord-285262-690kpupt	641	19	ganglia	ganglion	NNS
cord-285262-690kpupt	641	20	Target	target	VBP
cord-285262-690kpupt	641	21	protease	protease	NN
cord-285262-690kpupt	641	22	specificity	specificity	NN
cord-285262-690kpupt	641	23	of	of	IN
cord-285262-690kpupt	641	24	the	the	DT
cord-285262-690kpupt	641	25	viral	viral	JJ
cord-285262-690kpupt	641	26	serpin	serpin	NN
cord-285262-690kpupt	641	27	CrmA.	CrmA.	.
cord-285262-690kpupt	642	1	Analysis	analysis	NN
cord-285262-690kpupt	642	2	of	of	IN
cord-285262-690kpupt	642	3	five	five	CD
cord-285262-690kpupt	642	4	caspases	caspase	NNS
cord-285262-690kpupt	643	1	Nlrp9b	Nlrp9b	NNP
cord-285262-690kpupt	643	2	inflammasome	inflammasome	NNP
cord-285262-690kpupt	643	3	restricts	restrict	VBZ
cord-285262-690kpupt	643	4	rotavirus	rotavirus	JJ
cord-285262-690kpupt	643	5	infection	infection	NN
cord-285262-690kpupt	643	6	in	in	IN
cord-285262-690kpupt	643	7	intestinal	intestinal	JJ
cord-285262-690kpupt	643	8	epithelial	epithelial	JJ
cord-285262-690kpupt	643	9	cells	cell	NNS
cord-285262-690kpupt	643	10	Pyroptosis	Pyroptosis	NNP
cord-285262-690kpupt	643	11	induced	induce	VBN
cord-285262-690kpupt	643	12	by	by	IN
cord-285262-690kpupt	643	13	enterovirus	enterovirus	NN
cord-285262-690kpupt	643	14	A71	A71	NNP
cord-285262-690kpupt	643	15	infection	infection	NN
cord-285262-690kpupt	643	16	in	in	IN
cord-285262-690kpupt	643	17	cultured	cultured	JJ
cord-285262-690kpupt	643	18	human	human	JJ
cord-285262-690kpupt	643	19	neuroblastoma	neuroblastoma	NN
cord-285262-690kpupt	643	20	cells	cell	NNS
cord-285262-690kpupt	644	1	The	the	DT
cord-285262-690kpupt	644	2	author	author	NN
cord-285262-690kpupt	644	3	is	be	VBZ
cord-285262-690kpupt	644	4	grateful	grateful	JJ
cord-285262-690kpupt	644	5	to	to	IN
cord-285262-690kpupt	644	6	Madeleine	Madeleine	NNP
cord-285262-690kpupt	644	7	Eichler	Eichler	NNP
cord-285262-690kpupt	644	8	for	for	IN
cord-285262-690kpupt	644	9	the	the	DT
cord-285262-690kpupt	644	10	graphical	graphical	JJ
cord-285262-690kpupt	644	11	design	design	NN
cord-285262-690kpupt	644	12	of	of	IN
cord-285262-690kpupt	644	13	the	the	DT
cord-285262-690kpupt	644	14	figures	figure	NNS
cord-285262-690kpupt	644	15	presented	present	VBN
cord-285262-690kpupt	644	16	in	in	IN
cord-285262-690kpupt	644	17	the	the	DT
cord-285262-690kpupt	644	18	manuscript	manuscript	NN
cord-285262-690kpupt	644	19	and	and	CC
cord-285262-690kpupt	644	20	to	to	IN
cord-285262-690kpupt	644	21	Usman	Usman	NNP
cord-285262-690kpupt	644	22	Nasrullah	Nasrullah	NNP
cord-285262-690kpupt	644	23	for	for	IN
cord-285262-690kpupt	644	24	the	the	DT
cord-285262-690kpupt	644	25	critical	critical	JJ
cord-285262-690kpupt	644	26	reading	reading	NN
cord-285262-690kpupt	644	27	of	of	IN
cord-285262-690kpupt	644	28	the	the	DT
cord-285262-690kpupt	644	29	manuscript	manuscript	NN
cord-285262-690kpupt	644	30	.	.	.