id sid tid token lemma pos cord-282610-zim7nond 1 1 key key JJ cord-282610-zim7nond 1 2 : : : cord-282610-zim7nond 1 3 cord-282610-zim7nond cord-282610-zim7nond NNP cord-282610-zim7nond 1 4 authors author NNS cord-282610-zim7nond 1 5 : : : cord-282610-zim7nond 1 6 Proal Proal NNP cord-282610-zim7nond 1 7 , , , cord-282610-zim7nond 1 8 Amy Amy NNP cord-282610-zim7nond 1 9 ; ; : cord-282610-zim7nond 1 10 Marshall Marshall NNP cord-282610-zim7nond 1 11 , , , cord-282610-zim7nond 2 1 Trevor Trevor NNP cord-282610-zim7nond 2 2 title title NN cord-282610-zim7nond 2 3 : : : cord-282610-zim7nond 3 1 Myalgic Myalgic NNP cord-282610-zim7nond 3 2 Encephalomyelitis Encephalomyelitis NNP cord-282610-zim7nond 3 3 / / SYM cord-282610-zim7nond 3 4 Chronic Chronic NNP cord-282610-zim7nond 3 5 Fatigue Fatigue NNP cord-282610-zim7nond 3 6 Syndrome Syndrome NNP cord-282610-zim7nond 3 7 in in IN cord-282610-zim7nond 3 8 the the DT cord-282610-zim7nond 3 9 Era era NN cord-282610-zim7nond 3 10 of of IN cord-282610-zim7nond 3 11 the the DT cord-282610-zim7nond 3 12 Human Human NNP cord-282610-zim7nond 3 13 Microbiome Microbiome NNP cord-282610-zim7nond 3 14 : : : cord-282610-zim7nond 4 1 Persistent persistent JJ cord-282610-zim7nond 4 2 Pathogens Pathogens NNPS cord-282610-zim7nond 4 3 Drive drive VBP cord-282610-zim7nond 4 4 Chronic chronic JJ cord-282610-zim7nond 4 5 Symptoms symptom NNS cord-282610-zim7nond 4 6 by by IN cord-282610-zim7nond 4 7 Interfering interfere VBG cord-282610-zim7nond 4 8 With with IN cord-282610-zim7nond 4 9 Host Host NNP cord-282610-zim7nond 4 10 Metabolism Metabolism NNP cord-282610-zim7nond 4 11 , , , cord-282610-zim7nond 4 12 Gene Gene NNP cord-282610-zim7nond 4 13 Expression Expression NNP cord-282610-zim7nond 4 14 , , , cord-282610-zim7nond 4 15 and and CC cord-282610-zim7nond 4 16 Immunity Immunity NNP cord-282610-zim7nond 4 17 date date NN cord-282610-zim7nond 4 18 : : : cord-282610-zim7nond 5 1 2018 2018 CD cord-282610-zim7nond 5 2 - - SYM cord-282610-zim7nond 5 3 12 12 CD cord-282610-zim7nond 5 4 - - HYPH cord-282610-zim7nond 5 5 04 04 CD cord-282610-zim7nond 5 6 journal journal NN cord-282610-zim7nond 5 7 : : : cord-282610-zim7nond 6 1 Front Front NNP cord-282610-zim7nond 6 2 Pediatr Pediatr NNP cord-282610-zim7nond 6 3 DOI DOI NNP cord-282610-zim7nond 6 4 : : : cord-282610-zim7nond 6 5 10.3389 10.3389 CD cord-282610-zim7nond 6 6 / / SYM cord-282610-zim7nond 6 7 fped.2018.00373 fped.2018.00373 CD cord-282610-zim7nond 6 8 sha sha NNP cord-282610-zim7nond 6 9 : : : cord-282610-zim7nond 7 1 742745c77662d0b7923d6874c324e23f1edca6c0 742745c77662d0b7923d6874c324e23f1edca6c0 NNP cord-282610-zim7nond 7 2 doc_id doc_id CD cord-282610-zim7nond 7 3 : : : cord-282610-zim7nond 8 1 282610 282610 CD cord-282610-zim7nond 8 2 cord_uid cord_uid NNS cord-282610-zim7nond 8 3 : : : cord-282610-zim7nond 9 1 zim7nond zim7nond . cord-282610-zim7nond 10 1 The the DT cord-282610-zim7nond 10 2 illness illness NN cord-282610-zim7nond 10 3 ME ME NNP cord-282610-zim7nond 10 4 / / SYM cord-282610-zim7nond 10 5 CFS CFS NNP cord-282610-zim7nond 10 6 has have VBZ cord-282610-zim7nond 10 7 been be VBN cord-282610-zim7nond 10 8 repeatedly repeatedly RB cord-282610-zim7nond 10 9 tied tie VBN cord-282610-zim7nond 10 10 to to IN cord-282610-zim7nond 10 11 infectious infectious JJ cord-282610-zim7nond 10 12 agents agent NNS cord-282610-zim7nond 10 13 such such JJ cord-282610-zim7nond 10 14 as as IN cord-282610-zim7nond 10 15 Epstein Epstein NNP cord-282610-zim7nond 10 16 Barr Barr NNP cord-282610-zim7nond 10 17 Virus Virus NNP cord-282610-zim7nond 10 18 . . . cord-282610-zim7nond 11 1 Expanding expand VBG cord-282610-zim7nond 11 2 research research NN cord-282610-zim7nond 11 3 on on IN cord-282610-zim7nond 11 4 the the DT cord-282610-zim7nond 11 5 human human JJ cord-282610-zim7nond 11 6 microbiome microbiome NN cord-282610-zim7nond 11 7 now now RB cord-282610-zim7nond 11 8 allows allow VBZ cord-282610-zim7nond 11 9 ME ME NNP cord-282610-zim7nond 11 10 / / SYM cord-282610-zim7nond 11 11 CFS cfs NN cord-282610-zim7nond 11 12 - - HYPH cord-282610-zim7nond 11 13 associated associate VBN cord-282610-zim7nond 11 14 pathogens pathogen NNS cord-282610-zim7nond 11 15 to to TO cord-282610-zim7nond 11 16 be be VB cord-282610-zim7nond 11 17 studied study VBN cord-282610-zim7nond 11 18 as as IN cord-282610-zim7nond 11 19 interacting interact VBG cord-282610-zim7nond 11 20 members member NNS cord-282610-zim7nond 11 21 of of IN cord-282610-zim7nond 11 22 human human JJ cord-282610-zim7nond 11 23 microbiome microbiome NN cord-282610-zim7nond 11 24 communities community NNS cord-282610-zim7nond 11 25 . . . cord-282610-zim7nond 12 1 Humans human NNS cord-282610-zim7nond 12 2 harbor harbor VBP cord-282610-zim7nond 12 3 these these DT cord-282610-zim7nond 12 4 vast vast JJ cord-282610-zim7nond 12 5 ecosystems ecosystem NNS cord-282610-zim7nond 12 6 of of IN cord-282610-zim7nond 12 7 bacteria bacteria NNS cord-282610-zim7nond 12 8 , , , cord-282610-zim7nond 12 9 viruses virus NNS cord-282610-zim7nond 12 10 and and CC cord-282610-zim7nond 12 11 fungi fungus NNS cord-282610-zim7nond 12 12 in in IN cord-282610-zim7nond 12 13 nearly nearly RB cord-282610-zim7nond 12 14 all all DT cord-282610-zim7nond 12 15 tissue tissue NN cord-282610-zim7nond 12 16 and and CC cord-282610-zim7nond 12 17 blood blood NN cord-282610-zim7nond 12 18 . . . cord-282610-zim7nond 13 1 Most most RBS cord-282610-zim7nond 13 2 well well RB cord-282610-zim7nond 13 3 - - HYPH cord-282610-zim7nond 13 4 studied study VBN cord-282610-zim7nond 13 5 inflammatory inflammatory JJ cord-282610-zim7nond 13 6 conditions condition NNS cord-282610-zim7nond 13 7 are be VBP cord-282610-zim7nond 13 8 tied tie VBN cord-282610-zim7nond 13 9 to to IN cord-282610-zim7nond 13 10 dysbiosis dysbiosis NN cord-282610-zim7nond 13 11 or or CC cord-282610-zim7nond 13 12 imbalance imbalance NN cord-282610-zim7nond 13 13 of of IN cord-282610-zim7nond 13 14 the the DT cord-282610-zim7nond 13 15 human human JJ cord-282610-zim7nond 13 16 microbiome microbiome NN cord-282610-zim7nond 13 17 . . . cord-282610-zim7nond 14 1 While while IN cord-282610-zim7nond 14 2 gut gut NN cord-282610-zim7nond 14 3 microbiome microbiome NN cord-282610-zim7nond 14 4 dysbiosis dysbiosis NN cord-282610-zim7nond 14 5 has have VBZ cord-282610-zim7nond 14 6 been be VBN cord-282610-zim7nond 14 7 identified identify VBN cord-282610-zim7nond 14 8 in in IN cord-282610-zim7nond 14 9 ME ME NNP cord-282610-zim7nond 14 10 / / SYM cord-282610-zim7nond 14 11 CFS CFS NNP cord-282610-zim7nond 14 12 , , , cord-282610-zim7nond 14 13 microbes microbe NNS cord-282610-zim7nond 14 14 and and CC cord-282610-zim7nond 14 15 viruses virus NNS cord-282610-zim7nond 14 16 outside outside IN cord-282610-zim7nond 14 17 the the DT cord-282610-zim7nond 14 18 gut gut NN cord-282610-zim7nond 14 19 can can MD cord-282610-zim7nond 14 20 also also RB cord-282610-zim7nond 14 21 contribute contribute VB cord-282610-zim7nond 14 22 to to IN cord-282610-zim7nond 14 23 the the DT cord-282610-zim7nond 14 24 illness illness NN cord-282610-zim7nond 14 25 . . . cord-282610-zim7nond 15 1 Pathobionts Pathobionts NNP cord-282610-zim7nond 15 2 , , , cord-282610-zim7nond 15 3 and and CC cord-282610-zim7nond 15 4 their -PRON- PRP$ cord-282610-zim7nond 15 5 associated associate VBN cord-282610-zim7nond 15 6 proteins protein NNS cord-282610-zim7nond 15 7 / / SYM cord-282610-zim7nond 15 8 metabolites metabolite NNS cord-282610-zim7nond 15 9 , , , cord-282610-zim7nond 15 10 often often RB cord-282610-zim7nond 15 11 control control VBP cord-282610-zim7nond 15 12 human human JJ cord-282610-zim7nond 15 13 metabolism metabolism NN cord-282610-zim7nond 15 14 and and CC cord-282610-zim7nond 15 15 gene gene NN cord-282610-zim7nond 15 16 expression expression NN cord-282610-zim7nond 15 17 in in IN cord-282610-zim7nond 15 18 a a DT cord-282610-zim7nond 15 19 manner manner NN cord-282610-zim7nond 15 20 that that WDT cord-282610-zim7nond 15 21 pushes push VBZ cord-282610-zim7nond 15 22 the the DT cord-282610-zim7nond 15 23 body body NN cord-282610-zim7nond 15 24 toward toward IN cord-282610-zim7nond 15 25 a a DT cord-282610-zim7nond 15 26 state state NN cord-282610-zim7nond 15 27 of of IN cord-282610-zim7nond 15 28 illness illness NN cord-282610-zim7nond 15 29 . . . cord-282610-zim7nond 16 1 Intracellular Intracellular NNP cord-282610-zim7nond 16 2 pathogens pathogen NNS cord-282610-zim7nond 16 3 , , , cord-282610-zim7nond 16 4 including include VBG cord-282610-zim7nond 16 5 many many JJ cord-282610-zim7nond 16 6 associated associate VBN cord-282610-zim7nond 16 7 with with IN cord-282610-zim7nond 16 8 ME ME NNP cord-282610-zim7nond 16 9 / / SYM cord-282610-zim7nond 16 10 CFS CFS NNP cord-282610-zim7nond 16 11 , , , cord-282610-zim7nond 16 12 drive drive NN cord-282610-zim7nond 16 13 microbiome microbiome NN cord-282610-zim7nond 16 14 dysbiosis dysbiosis NN cord-282610-zim7nond 16 15 by by IN cord-282610-zim7nond 16 16 directly directly RB cord-282610-zim7nond 16 17 interfering interfere VBG cord-282610-zim7nond 16 18 with with IN cord-282610-zim7nond 16 19 human human JJ cord-282610-zim7nond 16 20 transcription transcription NN cord-282610-zim7nond 16 21 , , , cord-282610-zim7nond 16 22 translation translation NN cord-282610-zim7nond 16 23 , , , cord-282610-zim7nond 16 24 and and CC cord-282610-zim7nond 16 25 DNA dna NN cord-282610-zim7nond 16 26 repair repair NN cord-282610-zim7nond 16 27 processes process NNS cord-282610-zim7nond 16 28 . . . cord-282610-zim7nond 17 1 Molecular molecular JJ cord-282610-zim7nond 17 2 mimicry mimicry NN cord-282610-zim7nond 17 3 between between IN cord-282610-zim7nond 17 4 host host NN cord-282610-zim7nond 17 5 and and CC cord-282610-zim7nond 17 6 pathogen pathogen NN cord-282610-zim7nond 17 7 proteins protein NNS cord-282610-zim7nond 17 8 / / SYM cord-282610-zim7nond 17 9 metabolites metabolite NNS cord-282610-zim7nond 17 10 further further RB cord-282610-zim7nond 17 11 complicates complicate VBZ cord-282610-zim7nond 17 12 this this DT cord-282610-zim7nond 17 13 interference interference NN cord-282610-zim7nond 17 14 . . . cord-282610-zim7nond 18 1 Other other JJ cord-282610-zim7nond 18 2 human human JJ cord-282610-zim7nond 18 3 pathogens pathogen NNS cord-282610-zim7nond 18 4 disable disable VBP cord-282610-zim7nond 18 5 mitochondria mitochondrion NNS cord-282610-zim7nond 18 6 or or CC cord-282610-zim7nond 18 7 dysregulate dysregulate NN cord-282610-zim7nond 18 8 host host NN cord-282610-zim7nond 18 9 nervous nervous JJ cord-282610-zim7nond 18 10 system system NN cord-282610-zim7nond 18 11 signaling signal VBG cord-282610-zim7nond 18 12 . . . cord-282610-zim7nond 19 1 Antibodies antibody NNS cord-282610-zim7nond 19 2 and/or and/or CC cord-282610-zim7nond 19 3 clonal clonal JJ cord-282610-zim7nond 19 4 T t NN cord-282610-zim7nond 19 5 cells cell NNS cord-282610-zim7nond 19 6 identified identify VBN cord-282610-zim7nond 19 7 in in IN cord-282610-zim7nond 19 8 patients patient NNS cord-282610-zim7nond 19 9 with with IN cord-282610-zim7nond 19 10 ME ME NNP cord-282610-zim7nond 19 11 / / SYM cord-282610-zim7nond 19 12 CFS CFS NNP cord-282610-zim7nond 19 13 are be VBP cord-282610-zim7nond 19 14 likely likely RB cord-282610-zim7nond 19 15 activated activate VBN cord-282610-zim7nond 19 16 in in IN cord-282610-zim7nond 19 17 response response NN cord-282610-zim7nond 19 18 to to IN cord-282610-zim7nond 19 19 these these DT cord-282610-zim7nond 19 20 persistent persistent JJ cord-282610-zim7nond 19 21 microbiome microbiome NN cord-282610-zim7nond 19 22 pathogens pathogen NNS cord-282610-zim7nond 19 23 . . . cord-282610-zim7nond 20 1 Different different JJ cord-282610-zim7nond 20 2 human human JJ cord-282610-zim7nond 20 3 pathogens pathogen NNS cord-282610-zim7nond 20 4 have have VBP cord-282610-zim7nond 20 5 evolved evolve VBN cord-282610-zim7nond 20 6 similar similar JJ cord-282610-zim7nond 20 7 survival survival NN cord-282610-zim7nond 20 8 mechanisms mechanism NNS cord-282610-zim7nond 20 9 to to TO cord-282610-zim7nond 20 10 disable disable VB cord-282610-zim7nond 20 11 the the DT cord-282610-zim7nond 20 12 host host NN cord-282610-zim7nond 20 13 immune immune JJ cord-282610-zim7nond 20 14 response response NN cord-282610-zim7nond 20 15 and and CC cord-282610-zim7nond 20 16 host host NN cord-282610-zim7nond 20 17 metabolic metabolic JJ cord-282610-zim7nond 20 18 pathways pathway NNS cord-282610-zim7nond 20 19 . . . cord-282610-zim7nond 21 1 The the DT cord-282610-zim7nond 21 2 metabolic metabolic JJ cord-282610-zim7nond 21 3 dysfunction dysfunction NN cord-282610-zim7nond 21 4 driven drive VBN cord-282610-zim7nond 21 5 by by IN cord-282610-zim7nond 21 6 these these DT cord-282610-zim7nond 21 7 organisms organism NNS cord-282610-zim7nond 21 8 can can MD cord-282610-zim7nond 21 9 result result VB cord-282610-zim7nond 21 10 in in IN cord-282610-zim7nond 21 11 similar similar JJ cord-282610-zim7nond 21 12 clusters cluster NNS cord-282610-zim7nond 21 13 of of IN cord-282610-zim7nond 21 14 inflammatory inflammatory JJ cord-282610-zim7nond 21 15 symptoms symptom NNS cord-282610-zim7nond 21 16 . . . cord-282610-zim7nond 22 1 ME ME NNP cord-282610-zim7nond 22 2 / / SYM cord-282610-zim7nond 22 3 CFS CFS NNP cord-282610-zim7nond 22 4 may may MD cord-282610-zim7nond 22 5 be be VB cord-282610-zim7nond 22 6 driven drive VBN cord-282610-zim7nond 22 7 by by IN cord-282610-zim7nond 22 8 this this DT cord-282610-zim7nond 22 9 pathogen pathogen NN cord-282610-zim7nond 22 10 - - HYPH cord-282610-zim7nond 22 11 induced induce VBN cord-282610-zim7nond 22 12 dysfunction dysfunction NN cord-282610-zim7nond 22 13 , , , cord-282610-zim7nond 22 14 with with IN cord-282610-zim7nond 22 15 the the DT cord-282610-zim7nond 22 16 nature nature NN cord-282610-zim7nond 22 17 of of IN cord-282610-zim7nond 22 18 dysbiosis dysbiosis NN cord-282610-zim7nond 22 19 and and CC cord-282610-zim7nond 22 20 symptom symptom NN cord-282610-zim7nond 22 21 presentation presentation NN cord-282610-zim7nond 22 22 varying vary VBG cord-282610-zim7nond 22 23 based base VBN cord-282610-zim7nond 22 24 on on IN cord-282610-zim7nond 22 25 a a DT cord-282610-zim7nond 22 26 patient patient NN cord-282610-zim7nond 22 27 's 's POS cord-282610-zim7nond 22 28 unique unique JJ cord-282610-zim7nond 22 29 infectious infectious JJ cord-282610-zim7nond 22 30 and and CC cord-282610-zim7nond 22 31 environmental environmental JJ cord-282610-zim7nond 22 32 history history NN cord-282610-zim7nond 22 33 . . . cord-282610-zim7nond 23 1 Under under IN cord-282610-zim7nond 23 2 such such JJ cord-282610-zim7nond 23 3 conditions condition NNS cord-282610-zim7nond 23 4 , , , cord-282610-zim7nond 23 5 patients patient NNS cord-282610-zim7nond 23 6 would would MD cord-282610-zim7nond 23 7 benefit benefit VB cord-282610-zim7nond 23 8 from from IN cord-282610-zim7nond 23 9 treatments treatment NNS cord-282610-zim7nond 23 10 that that WDT cord-282610-zim7nond 23 11 support support VBP cord-282610-zim7nond 23 12 the the DT cord-282610-zim7nond 23 13 human human JJ cord-282610-zim7nond 23 14 immune immune JJ cord-282610-zim7nond 23 15 system system NN cord-282610-zim7nond 23 16 in in IN cord-282610-zim7nond 23 17 an an DT cord-282610-zim7nond 23 18 effort effort NN cord-282610-zim7nond 23 19 to to TO cord-282610-zim7nond 23 20 reverse reverse VB cord-282610-zim7nond 23 21 the the DT cord-282610-zim7nond 23 22 infectious infectious JJ cord-282610-zim7nond 23 23 disease disease NN cord-282610-zim7nond 23 24 process process NN cord-282610-zim7nond 23 25 . . . cord-282610-zim7nond 24 1 Toward toward IN cord-282610-zim7nond 24 2 the the DT cord-282610-zim7nond 24 3 end end NN cord-282610-zim7nond 24 4 of of IN cord-282610-zim7nond 24 5 a a DT cord-282610-zim7nond 24 6 career career NN cord-282610-zim7nond 24 7 spent spend VBN cord-282610-zim7nond 24 8 studying study VBG cord-282610-zim7nond 24 9 persistent persistent JJ cord-282610-zim7nond 24 10 bacteria bacteria NNS cord-282610-zim7nond 24 11 in in IN cord-282610-zim7nond 24 12 chronic chronic JJ cord-282610-zim7nond 24 13 disease disease NN cord-282610-zim7nond 24 14 , , , cord-282610-zim7nond 24 15 microbiologist microbiologist NN cord-282610-zim7nond 24 16 Gerald Gerald NNP cord-282610-zim7nond 24 17 Domingue Domingue NNP cord-282610-zim7nond 24 18 wrote write VBD cord-282610-zim7nond 24 19 , , , cord-282610-zim7nond 24 20 " " `` cord-282610-zim7nond 24 21 It -PRON- PRP cord-282610-zim7nond 24 22 is be VBZ cord-282610-zim7nond 24 23 unwise unwise JJ cord-282610-zim7nond 24 24 to to TO cord-282610-zim7nond 24 25 dismiss dismiss VB cord-282610-zim7nond 24 26 the the DT cord-282610-zim7nond 24 27 pathogenic pathogenic JJ cord-282610-zim7nond 24 28 capacities capacity NNS cord-282610-zim7nond 24 29 of of IN cord-282610-zim7nond 24 30 any any DT cord-282610-zim7nond 24 31 microbe microbe NN cord-282610-zim7nond 24 32 in in IN cord-282610-zim7nond 24 33 a a DT cord-282610-zim7nond 24 34 patient patient NN cord-282610-zim7nond 24 35 with with IN cord-282610-zim7nond 24 36 a a DT cord-282610-zim7nond 24 37 mysterious mysterious JJ cord-282610-zim7nond 24 38 disease disease NN cord-282610-zim7nond 24 39 " " '' cord-282610-zim7nond 24 40 ( ( -LRB- cord-282610-zim7nond 24 41 1 1 CD cord-282610-zim7nond 24 42 ) ) -RRB- cord-282610-zim7nond 24 43 . . . cord-282610-zim7nond 25 1 This this DT cord-282610-zim7nond 25 2 thinking thinking NN cord-282610-zim7nond 25 3 greatly greatly RB cord-282610-zim7nond 25 4 applies apply VBZ cord-282610-zim7nond 25 5 to to IN cord-282610-zim7nond 25 6 the the DT cord-282610-zim7nond 25 7 illness illness NN cord-282610-zim7nond 25 8 ME ME NNP cord-282610-zim7nond 25 9 / / SYM cord-282610-zim7nond 25 10 CFS CFS NNP cord-282610-zim7nond 25 11 . . . cord-282610-zim7nond 26 1 ME ME NNP cord-282610-zim7nond 26 2 / / SYM cord-282610-zim7nond 26 3 CFS CFS NNP cord-282610-zim7nond 26 4 is be VBZ cord-282610-zim7nond 26 5 characterized characterize VBN cord-282610-zim7nond 26 6 by by IN cord-282610-zim7nond 26 7 neuroinflammation neuroinflammation NN cord-282610-zim7nond 26 8 , , , cord-282610-zim7nond 26 9 severe severe JJ cord-282610-zim7nond 26 10 fatigue fatigue NN cord-282610-zim7nond 26 11 , , , cord-282610-zim7nond 26 12 excessive excessive JJ cord-282610-zim7nond 26 13 post post JJ cord-282610-zim7nond 26 14 - - JJ cord-282610-zim7nond 26 15 exertional exertional JJ cord-282610-zim7nond 26 16 exhaustion exhaustion NN cord-282610-zim7nond 26 17 , , , cord-282610-zim7nond 26 18 disturbed disturbed JJ cord-282610-zim7nond 26 19 sleep sleep NN cord-282610-zim7nond 26 20 , , , cord-282610-zim7nond 26 21 flu flu NN cord-282610-zim7nond 26 22 - - HYPH cord-282610-zim7nond 26 23 like like JJ cord-282610-zim7nond 26 24 episodes episode NNS cord-282610-zim7nond 26 25 , , , cord-282610-zim7nond 26 26 cognitive cognitive JJ cord-282610-zim7nond 26 27 problems problem NNS cord-282610-zim7nond 26 28 , , , cord-282610-zim7nond 26 29 sensory sensory JJ cord-282610-zim7nond 26 30 hypersensitivity hypersensitivity NN cord-282610-zim7nond 26 31 , , , cord-282610-zim7nond 26 32 muscle muscle NN cord-282610-zim7nond 26 33 and and CC cord-282610-zim7nond 26 34 joint joint JJ cord-282610-zim7nond 26 35 pain pain NN cord-282610-zim7nond 26 36 , , , cord-282610-zim7nond 26 37 headache headache NN cord-282610-zim7nond 26 38 , , , cord-282610-zim7nond 26 39 bowel bowel NN cord-282610-zim7nond 26 40 symptoms symptom NNS cord-282610-zim7nond 26 41 , , , cord-282610-zim7nond 26 42 and and CC cord-282610-zim7nond 26 43 severe severe JJ cord-282610-zim7nond 26 44 impairment impairment NN cord-282610-zim7nond 26 45 of of IN cord-282610-zim7nond 26 46 daily daily JJ cord-282610-zim7nond 26 47 functioning function VBG cord-282610-zim7nond 26 48 ( ( -LRB- cord-282610-zim7nond 26 49 2 2 CD cord-282610-zim7nond 26 50 ) ) -RRB- cord-282610-zim7nond 26 51 . . . cord-282610-zim7nond 27 1 Severely severely RB cord-282610-zim7nond 27 2 ill ill JJ cord-282610-zim7nond 27 3 individuals individual NNS cord-282610-zim7nond 27 4 are be VBP cord-282610-zim7nond 27 5 often often RB cord-282610-zim7nond 27 6 wheelchair wheelchair NN cord-282610-zim7nond 27 7 dependent dependent JJ cord-282610-zim7nond 27 8 , , , cord-282610-zim7nond 27 9 bedridden bedridden JJ cord-282610-zim7nond 27 10 , , , cord-282610-zim7nond 27 11 and and CC cord-282610-zim7nond 27 12 unable unable JJ cord-282610-zim7nond 27 13 to to TO cord-282610-zim7nond 27 14 perform perform VB cord-282610-zim7nond 27 15 basic basic JJ cord-282610-zim7nond 27 16 tasks task NNS cord-282610-zim7nond 27 17 of of IN cord-282610-zim7nond 27 18 work work NN cord-282610-zim7nond 27 19 or or CC cord-282610-zim7nond 27 20 daily daily JJ cord-282610-zim7nond 27 21 living living NN cord-282610-zim7nond 27 22 . . . cord-282610-zim7nond 28 1 The the DT cord-282610-zim7nond 28 2 history history NN cord-282610-zim7nond 28 3 of of IN cord-282610-zim7nond 28 4 ME ME NNP cord-282610-zim7nond 28 5 / / SYM cord-282610-zim7nond 28 6 CFS CFS NNP cord-282610-zim7nond 28 7 strongly strongly RB cord-282610-zim7nond 28 8 suggests suggest VBZ cord-282610-zim7nond 28 9 that that IN cord-282610-zim7nond 28 10 infectious infectious JJ cord-282610-zim7nond 28 11 agents agent NNS cord-282610-zim7nond 28 12 play play VBP cord-282610-zim7nond 28 13 a a DT cord-282610-zim7nond 28 14 central central JJ cord-282610-zim7nond 28 15 role role NN cord-282610-zim7nond 28 16 in in IN cord-282610-zim7nond 28 17 driving drive VBG cord-282610-zim7nond 28 18 the the DT cord-282610-zim7nond 28 19 disease disease NN cord-282610-zim7nond 28 20 process process NN cord-282610-zim7nond 28 21 . . . cord-282610-zim7nond 29 1 These these DT cord-282610-zim7nond 29 2 include include VBP cord-282610-zim7nond 29 3 early early JJ cord-282610-zim7nond 29 4 associations association NNS cord-282610-zim7nond 29 5 with with IN cord-282610-zim7nond 29 6 Epstein Epstein NNP cord-282610-zim7nond 29 7 Barr Barr NNP cord-282610-zim7nond 29 8 Virus Virus NNP cord-282610-zim7nond 29 9 ( ( -LRB- cord-282610-zim7nond 29 10 EBV)/Human EBV)/Human NNP cord-282610-zim7nond 29 11 Herpes Herpes NNP cord-282610-zim7nond 29 12 Virus Virus NNP cord-282610-zim7nond 29 13 6 6 CD cord-282610-zim7nond 29 14 ( ( -LRB- cord-282610-zim7nond 29 15 HHV6 HHV6 NNP cord-282610-zim7nond 29 16 ) ) -RRB- cord-282610-zim7nond 29 17 , , , cord-282610-zim7nond 29 18 the the DT cord-282610-zim7nond 29 19 relapsing relapse VBG cord-282610-zim7nond 29 20 - - HYPH cord-282610-zim7nond 29 21 remitting remit VBG cord-282610-zim7nond 29 22 nature nature NN cord-282610-zim7nond 29 23 of of IN cord-282610-zim7nond 29 24 ME ME NNP cord-282610-zim7nond 29 25 / / SYM cord-282610-zim7nond 29 26 CFS CFS NNP cord-282610-zim7nond 29 27 symptoms symptom NNS cord-282610-zim7nond 29 28 and and CC cord-282610-zim7nond 29 29 antibodies/"autoantibodies antibodies/"autoantibodie NNS cord-282610-zim7nond 29 30 " " `` cord-282610-zim7nond 29 31 detected detect VBN cord-282610-zim7nond 29 32 in in IN cord-282610-zim7nond 29 33 patients patient NNS cord-282610-zim7nond 29 34 with with IN cord-282610-zim7nond 29 35 the the DT cord-282610-zim7nond 29 36 disease disease NN cord-282610-zim7nond 29 37 ( ( -LRB- cord-282610-zim7nond 29 38 3 3 CD cord-282610-zim7nond 29 39 , , , cord-282610-zim7nond 29 40 4 4 CD cord-282610-zim7nond 29 41 ) ) -RRB- cord-282610-zim7nond 29 42 . . . cord-282610-zim7nond 30 1 A a DT cord-282610-zim7nond 30 2 number number NN cord-282610-zim7nond 30 3 of of IN cord-282610-zim7nond 30 4 ME ME NNP cord-282610-zim7nond 30 5 / / SYM cord-282610-zim7nond 30 6 CFS CFS NNP cord-282610-zim7nond 30 7 outbreaks outbreak NNS cord-282610-zim7nond 30 8 have have VBP cord-282610-zim7nond 30 9 also also RB cord-282610-zim7nond 30 10 been be VBN cord-282610-zim7nond 30 11 reported report VBN cord-282610-zim7nond 30 12 , , , cord-282610-zim7nond 30 13 in in IN cord-282610-zim7nond 30 14 which which WDT cord-282610-zim7nond 30 15 numerous numerous JJ cord-282610-zim7nond 30 16 people people NNS cord-282610-zim7nond 30 17 in in IN cord-282610-zim7nond 30 18 the the DT cord-282610-zim7nond 30 19 same same JJ cord-282610-zim7nond 30 20 geographical geographical JJ cord-282610-zim7nond 30 21 location location NN cord-282610-zim7nond 30 22 developed develop VBD cord-282610-zim7nond 30 23 the the DT cord-282610-zim7nond 30 24 illness illness NN cord-282610-zim7nond 30 25 simultaneously simultaneously RB cord-282610-zim7nond 30 26 ( ( -LRB- cord-282610-zim7nond 30 27 2 2 CD cord-282610-zim7nond 30 28 ) ) -RRB- cord-282610-zim7nond 30 29 . . . cord-282610-zim7nond 31 1 Indeed indeed RB cord-282610-zim7nond 31 2 , , , cord-282610-zim7nond 31 3 many many JJ cord-282610-zim7nond 31 4 ME ME NNP cord-282610-zim7nond 31 5 / / SYM cord-282610-zim7nond 31 6 CFS CFS NNP cord-282610-zim7nond 31 7 patients patient NNS cord-282610-zim7nond 31 8 present present JJ cord-282610-zim7nond 31 9 with with IN cord-282610-zim7nond 31 10 symptoms symptom NNS cord-282610-zim7nond 31 11 after after IN cord-282610-zim7nond 31 12 suffering suffer VBG cord-282610-zim7nond 31 13 from from IN cord-282610-zim7nond 31 14 a a DT cord-282610-zim7nond 31 15 severe severe JJ cord-282610-zim7nond 31 16 bacterial bacterial JJ cord-282610-zim7nond 31 17 or or CC cord-282610-zim7nond 31 18 viral viral JJ cord-282610-zim7nond 31 19 infection infection NN cord-282610-zim7nond 31 20 . . . cord-282610-zim7nond 32 1 These these DT cord-282610-zim7nond 32 2 infections infection NNS cord-282610-zim7nond 32 3 often often RB cord-282610-zim7nond 32 4 correlate correlate VBP cord-282610-zim7nond 32 5 with with IN cord-282610-zim7nond 32 6 travel travel NN cord-282610-zim7nond 32 7 to to IN cord-282610-zim7nond 32 8 a a DT cord-282610-zim7nond 32 9 foreign foreign JJ cord-282610-zim7nond 32 10 country country NN cord-282610-zim7nond 32 11 or or CC cord-282610-zim7nond 32 12 exposure exposure NN cord-282610-zim7nond 32 13 to to IN cord-282610-zim7nond 32 14 pollutants pollutant NNS cord-282610-zim7nond 32 15 or or CC cord-282610-zim7nond 32 16 molds mold NNS cord-282610-zim7nond 32 17 , , , cord-282610-zim7nond 32 18 suggesting suggest VBG cord-282610-zim7nond 32 19 that that IN cord-282610-zim7nond 32 20 such such JJ cord-282610-zim7nond 32 21 pathogens pathogen NNS cord-282610-zim7nond 32 22 take take VBP cord-282610-zim7nond 32 23 advantage advantage NN cord-282610-zim7nond 32 24 of of IN cord-282610-zim7nond 32 25 factors factor NNS cord-282610-zim7nond 32 26 that that WDT cord-282610-zim7nond 32 27 compromise compromise VBP cord-282610-zim7nond 32 28 the the DT cord-282610-zim7nond 32 29 host host NN cord-282610-zim7nond 32 30 immune immune JJ cord-282610-zim7nond 32 31 system system NN cord-282610-zim7nond 32 32 . . . cord-282610-zim7nond 33 1 Chronic chronic JJ cord-282610-zim7nond 33 2 inflammation inflammation NN cord-282610-zim7nond 33 3 is be VBZ cord-282610-zim7nond 33 4 a a DT cord-282610-zim7nond 33 5 hallmark hallmark NN cord-282610-zim7nond 33 6 of of IN cord-282610-zim7nond 33 7 persistent persistent JJ cord-282610-zim7nond 33 8 infection infection NN cord-282610-zim7nond 33 9 . . . cord-282610-zim7nond 34 1 Reports report NNS cord-282610-zim7nond 34 2 of of IN cord-282610-zim7nond 34 3 cytokine cytokine NN cord-282610-zim7nond 34 4 activation activation NN cord-282610-zim7nond 34 5 in in IN cord-282610-zim7nond 34 6 ME ME NNP cord-282610-zim7nond 34 7 / / SYM cord-282610-zim7nond 34 8 CFS CFS NNP cord-282610-zim7nond 34 9 clarify clarify VBP cord-282610-zim7nond 34 10 that that IN cord-282610-zim7nond 34 11 the the DT cord-282610-zim7nond 34 12 disease disease NN cord-282610-zim7nond 34 13 is be VBZ cord-282610-zim7nond 34 14 associated associate VBN cord-282610-zim7nond 34 15 with with IN cord-282610-zim7nond 34 16 an an DT cord-282610-zim7nond 34 17 inflammatory inflammatory JJ cord-282610-zim7nond 34 18 response response NN cord-282610-zim7nond 34 19 ( ( -LRB- cord-282610-zim7nond 34 20 5 5 CD cord-282610-zim7nond 34 21 ) ) -RRB- cord-282610-zim7nond 34 22 . . . cord-282610-zim7nond 35 1 Montoya Montoya NNP cord-282610-zim7nond 35 2 et et NNP cord-282610-zim7nond 35 3 al al NNP cord-282610-zim7nond 35 4 . . . cord-282610-zim7nond 36 1 ( ( -LRB- cord-282610-zim7nond 36 2 6 6 LS cord-282610-zim7nond 36 3 ) ) -RRB- cord-282610-zim7nond 36 4 found find VBD cord-282610-zim7nond 36 5 ME ME NNP cord-282610-zim7nond 36 6 / / SYM cord-282610-zim7nond 36 7 CFS CFS NNP cord-282610-zim7nond 36 8 cytokine cytokine NN cord-282610-zim7nond 36 9 activation activation NN cord-282610-zim7nond 36 10 increased increase VBD cord-282610-zim7nond 36 11 with with IN cord-282610-zim7nond 36 12 disease disease NN cord-282610-zim7nond 36 13 severity severity NN cord-282610-zim7nond 36 14 , , , cord-282610-zim7nond 36 15 suggesting suggest VBG cord-282610-zim7nond 36 16 patients patient NNS cord-282610-zim7nond 36 17 may may MD cord-282610-zim7nond 36 18 struggle struggle VB cord-282610-zim7nond 36 19 with with IN cord-282610-zim7nond 36 20 a a DT cord-282610-zim7nond 36 21 growing grow VBG cord-282610-zim7nond 36 22 infectious infectious JJ cord-282610-zim7nond 36 23 burden burden NN cord-282610-zim7nond 36 24 over over IN cord-282610-zim7nond 36 25 time time NN cord-282610-zim7nond 36 26 . . . cord-282610-zim7nond 37 1 Other other JJ cord-282610-zim7nond 37 2 ME ME NNP cord-282610-zim7nond 37 3 / / SYM cord-282610-zim7nond 37 4 CFS CFS NNP cord-282610-zim7nond 37 5 research research NN cord-282610-zim7nond 37 6 teams team NNS cord-282610-zim7nond 37 7 have have VBP cord-282610-zim7nond 37 8 identified identify VBN cord-282610-zim7nond 37 9 various various JJ cord-282610-zim7nond 37 10 forms form NNS cord-282610-zim7nond 37 11 of of IN cord-282610-zim7nond 37 12 mitochondrial mitochondrial JJ cord-282610-zim7nond 37 13 dysfunction dysfunction NN cord-282610-zim7nond 37 14 in in IN cord-282610-zim7nond 37 15 patients patient NNS cord-282610-zim7nond 37 16 with with IN cord-282610-zim7nond 37 17 the the DT cord-282610-zim7nond 37 18 illness illness NN cord-282610-zim7nond 37 19 ( ( -LRB- cord-282610-zim7nond 37 20 7 7 CD cord-282610-zim7nond 37 21 ) ) -RRB- cord-282610-zim7nond 37 22 . . . cord-282610-zim7nond 38 1 There there EX cord-282610-zim7nond 38 2 are be VBP cord-282610-zim7nond 38 3 now now RB cord-282610-zim7nond 38 4 dozens dozen NNS cord-282610-zim7nond 38 5 of of IN cord-282610-zim7nond 38 6 well well RB cord-282610-zim7nond 38 7 - - HYPH cord-282610-zim7nond 38 8 characterized characterize VBN cord-282610-zim7nond 38 9 mechanisms mechanism NNS cord-282610-zim7nond 38 10 by by IN cord-282610-zim7nond 38 11 which which WDT cord-282610-zim7nond 38 12 bacteria bacteria NNS cord-282610-zim7nond 38 13 and and CC cord-282610-zim7nond 38 14 viruses virus NNS cord-282610-zim7nond 38 15 dysregulate dysregulate VBP cord-282610-zim7nond 38 16 mitochondrial mitochondrial JJ cord-282610-zim7nond 38 17 metabolism metabolism NN cord-282610-zim7nond 38 18 ( ( -LRB- cord-282610-zim7nond 38 19 8 8 CD cord-282610-zim7nond 38 20 , , , cord-282610-zim7nond 38 21 9 9 CD cord-282610-zim7nond 38 22 ) ) -RRB- cord-282610-zim7nond 38 23 . . . cord-282610-zim7nond 39 1 Many many JJ cord-282610-zim7nond 39 2 research research NN cord-282610-zim7nond 39 3 teams team NNS cord-282610-zim7nond 39 4 have have VBP cord-282610-zim7nond 39 5 searched search VBN cord-282610-zim7nond 39 6 for for IN cord-282610-zim7nond 39 7 well well RB cord-282610-zim7nond 39 8 - - HYPH cord-282610-zim7nond 39 9 characterized characterize VBN cord-282610-zim7nond 39 10 single single JJ cord-282610-zim7nond 39 11 pathogens pathogen NNS cord-282610-zim7nond 39 12 in in IN cord-282610-zim7nond 39 13 patients patient NNS cord-282610-zim7nond 39 14 with with IN cord-282610-zim7nond 39 15 ME ME NNP cord-282610-zim7nond 39 16 / / SYM cord-282610-zim7nond 39 17 CFS CFS NNP cord-282610-zim7nond 39 18 . . . cord-282610-zim7nond 40 1 These these DT cord-282610-zim7nond 40 2 analyses analysis NNS cord-282610-zim7nond 40 3 often often RB cord-282610-zim7nond 40 4 reveal reveal VBP cord-282610-zim7nond 40 5 elevated elevated JJ cord-282610-zim7nond 40 6 titers titer NNS cord-282610-zim7nond 40 7 of of IN cord-282610-zim7nond 40 8 IGG IGG NNP cord-282610-zim7nond 40 9 and and CC cord-282610-zim7nond 40 10 IGM IGM NNP cord-282610-zim7nond 40 11 antibodies antibody NNS cord-282610-zim7nond 40 12 toward toward IN cord-282610-zim7nond 40 13 pathogens pathogen NNS cord-282610-zim7nond 40 14 such such JJ cord-282610-zim7nond 40 15 as as IN cord-282610-zim7nond 40 16 Epstein Epstein NNP cord-282610-zim7nond 40 17 Barr Barr NNP cord-282610-zim7nond 40 18 Virus Virus NNP cord-282610-zim7nond 40 19 , , , cord-282610-zim7nond 40 20 Cytomegalovirus Cytomegalovirus NNP cord-282610-zim7nond 40 21 , , , cord-282610-zim7nond 40 22 Parvovirus Parvovirus NNP cord-282610-zim7nond 40 23 19 19 CD cord-282610-zim7nond 40 24 and and CC cord-282610-zim7nond 40 25 M. M. NNP cord-282610-zim7nond 40 26 pneumonia pneumonia NN cord-282610-zim7nond 40 27 ( ( -LRB- cord-282610-zim7nond 40 28 2 2 CD cord-282610-zim7nond 40 29 , , , cord-282610-zim7nond 40 30 3 3 CD cord-282610-zim7nond 40 31 , , , cord-282610-zim7nond 40 32 10 10 CD cord-282610-zim7nond 40 33 ) ) -RRB- cord-282610-zim7nond 40 34 . . . cord-282610-zim7nond 41 1 Several several JJ cord-282610-zim7nond 41 2 teams team NNS cord-282610-zim7nond 41 3 have have VBP cord-282610-zim7nond 41 4 also also RB cord-282610-zim7nond 41 5 attempted attempt VBN cord-282610-zim7nond 41 6 to to TO cord-282610-zim7nond 41 7 identify identify VB cord-282610-zim7nond 41 8 a a DT cord-282610-zim7nond 41 9 single single JJ cord-282610-zim7nond 41 10 novel novel JJ cord-282610-zim7nond 41 11 pathogen pathogen NN cord-282610-zim7nond 41 12 that that WDT cord-282610-zim7nond 41 13 might may MD cord-282610-zim7nond 41 14 drive drive VB cord-282610-zim7nond 41 15 the the DT cord-282610-zim7nond 41 16 entire entire JJ cord-282610-zim7nond 41 17 ME ME NNP cord-282610-zim7nond 41 18 / / SYM cord-282610-zim7nond 41 19 CFS CFS NNP cord-282610-zim7nond 41 20 disease disease NN cord-282610-zim7nond 41 21 process process NN cord-282610-zim7nond 41 22 . . . cord-282610-zim7nond 42 1 However however RB cord-282610-zim7nond 42 2 , , , cord-282610-zim7nond 42 3 the the DT cord-282610-zim7nond 42 4 discovery discovery NN cord-282610-zim7nond 42 5 of of IN cord-282610-zim7nond 42 6 the the DT cord-282610-zim7nond 42 7 human human JJ cord-282610-zim7nond 42 8 microbiome microbiome NN cord-282610-zim7nond 42 9 now now RB cord-282610-zim7nond 42 10 allows allow VBZ cord-282610-zim7nond 42 11 single single JJ cord-282610-zim7nond 42 12 microbes microbe NNS cord-282610-zim7nond 42 13 and and CC cord-282610-zim7nond 42 14 viruses virus NNS cord-282610-zim7nond 42 15 to to TO cord-282610-zim7nond 42 16 be be VB cord-282610-zim7nond 42 17 studied study VBN cord-282610-zim7nond 42 18 as as IN cord-282610-zim7nond 42 19 members member NNS cord-282610-zim7nond 42 20 of of IN cord-282610-zim7nond 42 21 complex complex JJ cord-282610-zim7nond 42 22 communities community NNS cord-282610-zim7nond 42 23 . . . cord-282610-zim7nond 43 1 Humans human NNS cord-282610-zim7nond 43 2 harbor harbor VBP cord-282610-zim7nond 43 3 these these DT cord-282610-zim7nond 43 4 vast vast JJ cord-282610-zim7nond 43 5 ecosystems ecosystem NNS cord-282610-zim7nond 43 6 of of IN cord-282610-zim7nond 43 7 bacteria bacteria NNS cord-282610-zim7nond 43 8 , , , cord-282610-zim7nond 43 9 viruses virus NNS cord-282610-zim7nond 43 10 and and CC cord-282610-zim7nond 43 11 fungi fungus NNS cord-282610-zim7nond 43 12 in in IN cord-282610-zim7nond 43 13 nearly nearly RB cord-282610-zim7nond 43 14 all all DT cord-282610-zim7nond 43 15 tissue tissue NN cord-282610-zim7nond 43 16 and and CC cord-282610-zim7nond 43 17 blood blood NN cord-282610-zim7nond 43 18 ( ( -LRB- cord-282610-zim7nond 43 19 11 11 CD cord-282610-zim7nond 43 20 ) ) -RRB- cord-282610-zim7nond 43 21 ( ( -LRB- cord-282610-zim7nond 43 22 12 12 CD cord-282610-zim7nond 43 23 ) ) -RRB- cord-282610-zim7nond 43 24 ( ( -LRB- cord-282610-zim7nond 43 25 13 13 CD cord-282610-zim7nond 43 26 ) ) -RRB- cord-282610-zim7nond 44 1 ( ( -LRB- cord-282610-zim7nond 44 2 14 14 CD cord-282610-zim7nond 44 3 ) ) -RRB- cord-282610-zim7nond 44 4 . . . cord-282610-zim7nond 45 1 Organisms organism NNS cord-282610-zim7nond 45 2 in in IN cord-282610-zim7nond 45 3 the the DT cord-282610-zim7nond 45 4 microbiome microbiome NN cord-282610-zim7nond 45 5 continually continually RB cord-282610-zim7nond 45 6 interact interact VBP cord-282610-zim7nond 45 7 with with IN cord-282610-zim7nond 45 8 each each DT cord-282610-zim7nond 45 9 other other JJ cord-282610-zim7nond 45 10 , , , cord-282610-zim7nond 45 11 and and CC cord-282610-zim7nond 45 12 with with IN cord-282610-zim7nond 45 13 the the DT cord-282610-zim7nond 45 14 human human JJ cord-282610-zim7nond 45 15 genome genome NN cord-282610-zim7nond 45 16 , , , cord-282610-zim7nond 45 17 to to TO cord-282610-zim7nond 45 18 regulate regulate VB cord-282610-zim7nond 45 19 host host NN cord-282610-zim7nond 45 20 metabolism metabolism NN cord-282610-zim7nond 45 21 and and CC cord-282610-zim7nond 45 22 gene gene NN cord-282610-zim7nond 45 23 expression expression NN cord-282610-zim7nond 45 24 in in IN cord-282610-zim7nond 45 25 both both DT cord-282610-zim7nond 45 26 health health NN cord-282610-zim7nond 45 27 and and CC cord-282610-zim7nond 45 28 disease disease NN cord-282610-zim7nond 45 29 ( ( -LRB- cord-282610-zim7nond 45 30 15 15 CD cord-282610-zim7nond 45 31 , , , cord-282610-zim7nond 45 32 16 16 CD cord-282610-zim7nond 45 33 ) ) -RRB- cord-282610-zim7nond 45 34 . . . cord-282610-zim7nond 46 1 A a DT cord-282610-zim7nond 46 2 growing grow VBG cord-282610-zim7nond 46 3 number number NN cord-282610-zim7nond 46 4 of of IN cord-282610-zim7nond 46 5 inflammatory inflammatory JJ cord-282610-zim7nond 46 6 disease disease NN cord-282610-zim7nond 46 7 states state NNS cord-282610-zim7nond 46 8 , , , cord-282610-zim7nond 46 9 including include VBG cord-282610-zim7nond 46 10 neurological neurological JJ cord-282610-zim7nond 46 11 conditions condition NNS cord-282610-zim7nond 46 12 and and CC cord-282610-zim7nond 46 13 cancers cancer NNS cord-282610-zim7nond 46 14 , , , cord-282610-zim7nond 46 15 are be VBP cord-282610-zim7nond 46 16 tied tie VBN cord-282610-zim7nond 46 17 to to IN cord-282610-zim7nond 46 18 dysbiosis dysbiosis NN cord-282610-zim7nond 46 19 or or CC cord-282610-zim7nond 46 20 imbalance imbalance NN cord-282610-zim7nond 46 21 of of IN cord-282610-zim7nond 46 22 these these DT cord-282610-zim7nond 46 23 human human JJ cord-282610-zim7nond 46 24 microbiome microbiome NN cord-282610-zim7nond 46 25 communities community NNS cord-282610-zim7nond 46 26 ( ( -LRB- cord-282610-zim7nond 46 27 17 17 CD cord-282610-zim7nond 46 28 ) ) -RRB- cord-282610-zim7nond 46 29 ( ( -LRB- cord-282610-zim7nond 46 30 18 18 CD cord-282610-zim7nond 46 31 ) ) -RRB- cord-282610-zim7nond 46 32 ( ( -LRB- cord-282610-zim7nond 46 33 19 19 CD cord-282610-zim7nond 46 34 ) ) -RRB- cord-282610-zim7nond 46 35 ( ( -LRB- cord-282610-zim7nond 46 36 20 20 CD cord-282610-zim7nond 46 37 ) ) -RRB- cord-282610-zim7nond 46 38 . . . cord-282610-zim7nond 47 1 Gut gut JJ cord-282610-zim7nond 47 2 microbiome microbiome NN cord-282610-zim7nond 47 3 dysbiosis dysbiosis NN cord-282610-zim7nond 47 4 has have VBZ cord-282610-zim7nond 47 5 been be VBN cord-282610-zim7nond 47 6 identified identify VBN cord-282610-zim7nond 47 7 in in IN cord-282610-zim7nond 47 8 ME ME NNP cord-282610-zim7nond 47 9 / / SYM cord-282610-zim7nond 47 10 CFS CFS NNP cord-282610-zim7nond 47 11 ( ( -LRB- cord-282610-zim7nond 47 12 21 21 CD cord-282610-zim7nond 47 13 ) ) -RRB- cord-282610-zim7nond 47 14 . . . cord-282610-zim7nond 48 1 This this DT cord-282610-zim7nond 48 2 dysbiosis dysbiosis NN cord-282610-zim7nond 48 3 is be VBZ cord-282610-zim7nond 48 4 characterized characterize VBN cord-282610-zim7nond 48 5 by by IN cord-282610-zim7nond 48 6 changes change NNS cord-282610-zim7nond 48 7 in in IN cord-282610-zim7nond 48 8 microbe microbe NN cord-282610-zim7nond 48 9 species specie NNS cord-282610-zim7nond 48 10 composition composition NN cord-282610-zim7nond 48 11 and/or and/or CC cord-282610-zim7nond 48 12 diversity diversity NN cord-282610-zim7nond 48 13 . . . cord-282610-zim7nond 49 1 Pathogens pathogen NNS cord-282610-zim7nond 49 2 , , , cord-282610-zim7nond 49 3 or or CC cord-282610-zim7nond 49 4 groups group NNS cord-282610-zim7nond 49 5 of of IN cord-282610-zim7nond 49 6 pathogens pathogen NNS cord-282610-zim7nond 49 7 , , , cord-282610-zim7nond 49 8 can can MD cord-282610-zim7nond 49 9 promote promote VB cord-282610-zim7nond 49 10 dysbiosis dysbiosis NN cord-282610-zim7nond 49 11 by by IN cord-282610-zim7nond 49 12 altering alter VBG cord-282610-zim7nond 49 13 their -PRON- PRP$ cord-282610-zim7nond 49 14 gene gene NN cord-282610-zim7nond 49 15 expression expression NN cord-282610-zim7nond 49 16 in in IN cord-282610-zim7nond 49 17 ways way NNS cord-282610-zim7nond 49 18 that that WDT cord-282610-zim7nond 49 19 promote promote VBP cord-282610-zim7nond 49 20 virulence virulence NN cord-282610-zim7nond 49 21 , , , cord-282610-zim7nond 49 22 immunosuppression immunosuppression NN cord-282610-zim7nond 49 23 and and CC cord-282610-zim7nond 49 24 dysregulation dysregulation NN cord-282610-zim7nond 49 25 of of IN cord-282610-zim7nond 49 26 host host NN cord-282610-zim7nond 49 27 genetic genetic JJ cord-282610-zim7nond 49 28 and and CC cord-282610-zim7nond 49 29 metabolic metabolic JJ cord-282610-zim7nond 49 30 pathways pathway NNS cord-282610-zim7nond 49 31 ( ( -LRB- cord-282610-zim7nond 49 32 22 22 CD cord-282610-zim7nond 49 33 ) ) -RRB- cord-282610-zim7nond 49 34 . . . cord-282610-zim7nond 50 1 When when WRB cord-282610-zim7nond 50 2 seemingly seemingly RB cord-282610-zim7nond 50 3 disparate disparate JJ cord-282610-zim7nond 50 4 biomedical biomedical JJ cord-282610-zim7nond 50 5 findings finding NNS cord-282610-zim7nond 50 6 on on IN cord-282610-zim7nond 50 7 ME ME NNP cord-282610-zim7nond 50 8 / / SYM cord-282610-zim7nond 50 9 CFS CFS NNP cord-282610-zim7nond 50 10 are be VBP cord-282610-zim7nond 50 11 interpreted interpret VBN cord-282610-zim7nond 50 12 through through IN cord-282610-zim7nond 50 13 the the DT cord-282610-zim7nond 50 14 lens lens NN cord-282610-zim7nond 50 15 of of IN cord-282610-zim7nond 50 16 these these DT cord-282610-zim7nond 50 17 microbiome microbiome NN cord-282610-zim7nond 50 18 - - HYPH cord-282610-zim7nond 50 19 based base VBN cord-282610-zim7nond 50 20 paradigms paradigm NNS cord-282610-zim7nond 50 21 and and CC cord-282610-zim7nond 50 22 platforms platform NNS cord-282610-zim7nond 50 23 , , , cord-282610-zim7nond 50 24 a a DT cord-282610-zim7nond 50 25 cohesive cohesive JJ cord-282610-zim7nond 50 26 picture picture NN cord-282610-zim7nond 50 27 of of IN cord-282610-zim7nond 50 28 the the DT cord-282610-zim7nond 50 29 ME ME NNP cord-282610-zim7nond 50 30 / / SYM cord-282610-zim7nond 50 31 CFS CFS NNP cord-282610-zim7nond 50 32 disease disease NN cord-282610-zim7nond 50 33 process process NN cord-282610-zim7nond 50 34 emerges emerge VBZ cord-282610-zim7nond 50 35 . . . cord-282610-zim7nond 51 1 ME ME NNP cord-282610-zim7nond 51 2 / / SYM cord-282610-zim7nond 51 3 CFS CFS NNP cord-282610-zim7nond 51 4 may may MD cord-282610-zim7nond 51 5 be be VB cord-282610-zim7nond 51 6 driven drive VBN cord-282610-zim7nond 51 7 by by IN cord-282610-zim7nond 51 8 pathogeninduced pathogeninduced JJ cord-282610-zim7nond 51 9 dysfunction dysfunction NN cord-282610-zim7nond 51 10 , , , cord-282610-zim7nond 51 11 with with IN cord-282610-zim7nond 51 12 resulting result VBG cord-282610-zim7nond 51 13 microbiome microbiome NN cord-282610-zim7nond 51 14 dysbiosis dysbiosis NN cord-282610-zim7nond 51 15 varying vary VBG cord-282610-zim7nond 51 16 based base VBN cord-282610-zim7nond 51 17 on on IN cord-282610-zim7nond 51 18 a a DT cord-282610-zim7nond 51 19 patient patient NN cord-282610-zim7nond 51 20 's 's POS cord-282610-zim7nond 51 21 unique unique JJ cord-282610-zim7nond 51 22 infectious infectious JJ cord-282610-zim7nond 51 23 and and CC cord-282610-zim7nond 51 24 environmental environmental JJ cord-282610-zim7nond 51 25 history history NN cord-282610-zim7nond 51 26 . . . cord-282610-zim7nond 52 1 Under under IN cord-282610-zim7nond 52 2 such such JJ cord-282610-zim7nond 52 3 conditions condition NNS cord-282610-zim7nond 52 4 , , , cord-282610-zim7nond 52 5 patients patient NNS cord-282610-zim7nond 52 6 would would MD cord-282610-zim7nond 52 7 benefit benefit VB cord-282610-zim7nond 52 8 from from IN cord-282610-zim7nond 52 9 treatments treatment NNS cord-282610-zim7nond 52 10 that that WDT cord-282610-zim7nond 52 11 , , , cord-282610-zim7nond 52 12 like like IN cord-282610-zim7nond 52 13 those those DT cord-282610-zim7nond 52 14 now now RB cord-282610-zim7nond 52 15 being be VBG cord-282610-zim7nond 52 16 developed develop VBN cord-282610-zim7nond 52 17 for for IN cord-282610-zim7nond 52 18 cancer cancer NN cord-282610-zim7nond 52 19 , , , cord-282610-zim7nond 52 20 support support VB cord-282610-zim7nond 52 21 the the DT cord-282610-zim7nond 52 22 human human JJ cord-282610-zim7nond 52 23 immune immune JJ cord-282610-zim7nond 52 24 system system NN cord-282610-zim7nond 52 25 in in IN cord-282610-zim7nond 52 26 an an DT cord-282610-zim7nond 52 27 effort effort NN cord-282610-zim7nond 52 28 to to TO cord-282610-zim7nond 52 29 reverse reverse VB cord-282610-zim7nond 52 30 the the DT cord-282610-zim7nond 52 31 inflammatory inflammatory JJ cord-282610-zim7nond 52 32 disease disease NN cord-282610-zim7nond 52 33 process process NN cord-282610-zim7nond 52 34 . . . cord-282610-zim7nond 53 1 In in IN cord-282610-zim7nond 53 2 the the DT cord-282610-zim7nond 53 3 USA USA NNP cord-282610-zim7nond 53 4 , , , cord-282610-zim7nond 53 5 ME ME NNP cord-282610-zim7nond 53 6 / / SYM cord-282610-zim7nond 53 7 CFS CFS NNP cord-282610-zim7nond 53 8 cases case NNS cord-282610-zim7nond 53 9 were be VBD cord-282610-zim7nond 53 10 first first RB cord-282610-zim7nond 53 11 formally formally RB cord-282610-zim7nond 53 12 reported report VBN cord-282610-zim7nond 53 13 to to IN cord-282610-zim7nond 53 14 the the DT cord-282610-zim7nond 53 15 CDC CDC NNP cord-282610-zim7nond 53 16 in in IN cord-282610-zim7nond 53 17 the the DT cord-282610-zim7nond 53 18 1980s 1980 NNS cord-282610-zim7nond 53 19 ( ( -LRB- cord-282610-zim7nond 53 20 2 2 CD cord-282610-zim7nond 53 21 ) ) -RRB- cord-282610-zim7nond 53 22 . . . cord-282610-zim7nond 54 1 At at IN cord-282610-zim7nond 54 2 the the DT cord-282610-zim7nond 54 3 time time NN cord-282610-zim7nond 54 4 , , , cord-282610-zim7nond 54 5 human human JJ cord-282610-zim7nond 54 6 microbes microbe NNS cord-282610-zim7nond 54 7 were be VBD cord-282610-zim7nond 54 8 typically typically RB cord-282610-zim7nond 54 9 only only RB cord-282610-zim7nond 54 10 detected detect VBN cord-282610-zim7nond 54 11 with with IN cord-282610-zim7nond 54 12 culture culture NN cord-282610-zim7nond 54 13 - - HYPH cord-282610-zim7nond 54 14 based base VBN cord-282610-zim7nond 54 15 laboratory laboratory NN cord-282610-zim7nond 54 16 methods method NNS cord-282610-zim7nond 54 17 . . . cord-282610-zim7nond 55 1 Then then RB cord-282610-zim7nond 55 2 , , , cord-282610-zim7nond 55 3 around around IN cord-282610-zim7nond 55 4 the the DT cord-282610-zim7nond 55 5 year year NN cord-282610-zim7nond 55 6 2000 2000 CD cord-282610-zim7nond 55 7 , , , cord-282610-zim7nond 55 8 novel novel JJ cord-282610-zim7nond 55 9 genome genome NN cord-282610-zim7nond 55 10 - - HYPH cord-282610-zim7nond 55 11 based base VBN cord-282610-zim7nond 55 12 technologies technology NNS cord-282610-zim7nond 55 13 began begin VBD cord-282610-zim7nond 55 14 to to TO cord-282610-zim7nond 55 15 revolutionize revolutionize VB cord-282610-zim7nond 55 16 the the DT cord-282610-zim7nond 55 17 field field NN cord-282610-zim7nond 55 18 of of IN cord-282610-zim7nond 55 19 microbiology microbiology NN cord-282610-zim7nond 55 20 ( ( -LRB- cord-282610-zim7nond 55 21 23 23 CD cord-282610-zim7nond 55 22 , , , cord-282610-zim7nond 55 23 24 24 CD cord-282610-zim7nond 55 24 ) ) -RRB- cord-282610-zim7nond 55 25 . . . cord-282610-zim7nond 56 1 These these DT cord-282610-zim7nond 56 2 technologies technology NNS cord-282610-zim7nond 56 3 identify identify VBP cord-282610-zim7nond 56 4 microbes microbe NNS cord-282610-zim7nond 56 5 based base VBN cord-282610-zim7nond 56 6 on on IN cord-282610-zim7nond 56 7 their -PRON- PRP$ cord-282610-zim7nond 56 8 DNA DNA NNP cord-282610-zim7nond 56 9 or or CC cord-282610-zim7nond 56 10 RNA RNA NNP cord-282610-zim7nond 56 11 signatures signature NNS cord-282610-zim7nond 56 12 rather rather RB cord-282610-zim7nond 56 13 than than IN cord-282610-zim7nond 56 14 their -PRON- PRP$ cord-282610-zim7nond 56 15 ability ability NN cord-282610-zim7nond 56 16 to to TO cord-282610-zim7nond 56 17 grow grow VB cord-282610-zim7nond 56 18 in in IN cord-282610-zim7nond 56 19 the the DT cord-282610-zim7nond 56 20 laboratory laboratory NN cord-282610-zim7nond 56 21 . . . cord-282610-zim7nond 57 1 The the DT cord-282610-zim7nond 57 2 results result NNS cord-282610-zim7nond 57 3 of of IN cord-282610-zim7nond 57 4 these these DT cord-282610-zim7nond 57 5 genome genome NN cord-282610-zim7nond 57 6 - - HYPH cord-282610-zim7nond 57 7 based base VBN cord-282610-zim7nond 57 8 analyses analysis NNS cord-282610-zim7nond 57 9 were be VBD cord-282610-zim7nond 57 10 remarkable remarkable JJ cord-282610-zim7nond 57 11 : : : cord-282610-zim7nond 57 12 vast vast JJ cord-282610-zim7nond 57 13 communities community NNS cord-282610-zim7nond 57 14 of of IN cord-282610-zim7nond 57 15 microbes microbe NNS cord-282610-zim7nond 57 16 were be VBD cord-282610-zim7nond 57 17 identified identify VBN cord-282610-zim7nond 57 18 in in IN cord-282610-zim7nond 57 19 the the DT cord-282610-zim7nond 57 20 human human JJ cord-282610-zim7nond 57 21 body body NN cord-282610-zim7nond 57 22 that that WDT cord-282610-zim7nond 57 23 had have VBD cord-282610-zim7nond 57 24 been be VBN cord-282610-zim7nond 57 25 missed miss VBN cord-282610-zim7nond 57 26 by by IN cord-282610-zim7nond 57 27 the the DT cord-282610-zim7nond 57 28 older old JJR cord-282610-zim7nond 57 29 culture culture NN cord-282610-zim7nond 57 30 - - HYPH cord-282610-zim7nond 57 31 based base VBN cord-282610-zim7nond 57 32 techniques technique NNS cord-282610-zim7nond 57 33 . . . cord-282610-zim7nond 58 1 These these DT cord-282610-zim7nond 58 2 extensive extensive JJ cord-282610-zim7nond 58 3 ecosystems ecosystem NNS cord-282610-zim7nond 58 4 of of IN cord-282610-zim7nond 58 5 bacteria bacteria NNS cord-282610-zim7nond 58 6 , , , cord-282610-zim7nond 58 7 viruses virus NNS cord-282610-zim7nond 58 8 , , , cord-282610-zim7nond 58 9 fungi fungus NNS cord-282610-zim7nond 58 10 , , , cord-282610-zim7nond 58 11 and and CC cord-282610-zim7nond 58 12 archaea archaea NNS cord-282610-zim7nond 58 13 are be VBP cord-282610-zim7nond 58 14 collectively collectively RB cord-282610-zim7nond 58 15 known know VBN cord-282610-zim7nond 58 16 as as IN cord-282610-zim7nond 58 17 the the DT cord-282610-zim7nond 58 18 human human JJ cord-282610-zim7nond 58 19 microbiome microbiome NN cord-282610-zim7nond 58 20 ( ( -LRB- cord-282610-zim7nond 58 21 25 25 CD cord-282610-zim7nond 58 22 ) ) -RRB- cord-282610-zim7nond 59 1 ( ( -LRB- cord-282610-zim7nond 59 2 26 26 CD cord-282610-zim7nond 59 3 ) ) -RRB- cord-282610-zim7nond 59 4 ( ( -LRB- cord-282610-zim7nond 59 5 27 27 CD cord-282610-zim7nond 59 6 ) ) -RRB- cord-282610-zim7nond 59 7 . . . cord-282610-zim7nond 60 1 Today today NN cord-282610-zim7nond 60 2 , , , cord-282610-zim7nond 60 3 so so RB cord-282610-zim7nond 60 4 many many JJ cord-282610-zim7nond 60 5 novel novel JJ cord-282610-zim7nond 60 6 microbes microbe NNS cord-282610-zim7nond 60 7 have have VBP cord-282610-zim7nond 60 8 been be VBN cord-282610-zim7nond 60 9 identified identify VBN cord-282610-zim7nond 60 10 in in IN cord-282610-zim7nond 60 11 Homo Homo NNP cord-282610-zim7nond 60 12 sapiens sapiens JJ cord-282610-zim7nond 60 13 that that IN cord-282610-zim7nond 60 14 our -PRON- PRP$ cord-282610-zim7nond 60 15 human human JJ cord-282610-zim7nond 60 16 cells cell NNS cord-282610-zim7nond 60 17 are be VBP cord-282610-zim7nond 60 18 equivalent equivalent JJ cord-282610-zim7nond 60 19 to to IN cord-282610-zim7nond 60 20 or or CC cord-282610-zim7nond 60 21 even even RB cord-282610-zim7nond 60 22 outnumbered outnumber VBN cord-282610-zim7nond 60 23 by by IN cord-282610-zim7nond 60 24 those those DT cord-282610-zim7nond 60 25 of of IN cord-282610-zim7nond 60 26 our -PRON- PRP$ cord-282610-zim7nond 60 27 microbial microbial JJ cord-282610-zim7nond 60 28 inhabitants inhabitant NNS cord-282610-zim7nond 60 29 ( ( -LRB- cord-282610-zim7nond 60 30 28 28 CD cord-282610-zim7nond 60 31 ) ) -RRB- cord-282610-zim7nond 60 32 . . . cord-282610-zim7nond 61 1 The the DT cord-282610-zim7nond 61 2 tens ten NNS cord-282610-zim7nond 61 3 of of IN cord-282610-zim7nond 61 4 millions million NNS cord-282610-zim7nond 61 5 of of IN cord-282610-zim7nond 61 6 unique unique JJ cord-282610-zim7nond 61 7 genes gene NNS cord-282610-zim7nond 61 8 harbored harbor VBN cord-282610-zim7nond 61 9 by by IN cord-282610-zim7nond 61 10 this this DT cord-282610-zim7nond 61 11 microbiome microbiome NN cord-282610-zim7nond 61 12 dwarf dwarf NN cord-282610-zim7nond 61 13 the the DT cord-282610-zim7nond 61 14 ∼20,500 ∼20,500 CD cord-282610-zim7nond 61 15 genes gene NNS cord-282610-zim7nond 61 16 in in IN cord-282610-zim7nond 61 17 the the DT cord-282610-zim7nond 61 18 human human JJ cord-282610-zim7nond 61 19 genome genome NN cord-282610-zim7nond 61 20 ( ( -LRB- cord-282610-zim7nond 61 21 12 12 CD cord-282610-zim7nond 61 22 , , , cord-282610-zim7nond 61 23 29 29 CD cord-282610-zim7nond 61 24 ) ) -RRB- cord-282610-zim7nond 61 25 . . . cord-282610-zim7nond 62 1 For for IN cord-282610-zim7nond 62 2 example example NN cord-282610-zim7nond 62 3 , , , cord-282610-zim7nond 62 4 just just RB cord-282610-zim7nond 62 5 one one CD cord-282610-zim7nond 62 6 2017 2017 CD cord-282610-zim7nond 62 7 analysis analysis NN cord-282610-zim7nond 62 8 of of IN cord-282610-zim7nond 62 9 the the DT cord-282610-zim7nond 62 10 human human JJ cord-282610-zim7nond 62 11 gut gut NN cord-282610-zim7nond 62 12 , , , cord-282610-zim7nond 62 13 skin skin NN cord-282610-zim7nond 62 14 , , , cord-282610-zim7nond 62 15 mouth mouth NN cord-282610-zim7nond 62 16 , , , cord-282610-zim7nond 62 17 and and CC cord-282610-zim7nond 62 18 vaginal vaginal JJ cord-282610-zim7nond 62 19 microbiomes microbiome NNS cord-282610-zim7nond 62 20 uncovered uncover VBD cord-282610-zim7nond 62 21 millions million NNS cord-282610-zim7nond 62 22 of of IN cord-282610-zim7nond 62 23 previously previously RB cord-282610-zim7nond 62 24 unknown unknown JJ cord-282610-zim7nond 62 25 microbial microbial JJ cord-282610-zim7nond 62 26 genes gene NNS cord-282610-zim7nond 62 27 ( ( -LRB- cord-282610-zim7nond 62 28 11 11 CD cord-282610-zim7nond 62 29 ) ) -RRB- cord-282610-zim7nond 62 30 . . . cord-282610-zim7nond 63 1 This this DT cord-282610-zim7nond 63 2 has have VBZ cord-282610-zim7nond 63 3 forced force VBN cord-282610-zim7nond 63 4 science science NN cord-282610-zim7nond 63 5 to to TO cord-282610-zim7nond 63 6 redefine redefine VB cord-282610-zim7nond 63 7 the the DT cord-282610-zim7nond 63 8 human human JJ cord-282610-zim7nond 63 9 condition condition NN cord-282610-zim7nond 63 10 . . . cord-282610-zim7nond 64 1 Humans human NNS cord-282610-zim7nond 64 2 are be VBP cord-282610-zim7nond 64 3 best best RB cord-282610-zim7nond 64 4 described describe VBN cord-282610-zim7nond 64 5 as as IN cord-282610-zim7nond 64 6 holobionts holobiont NNS cord-282610-zim7nond 64 7 , , , cord-282610-zim7nond 64 8 in in IN cord-282610-zim7nond 64 9 which which WDT cord-282610-zim7nond 64 10 the the DT cord-282610-zim7nond 64 11 microbial microbial JJ cord-282610-zim7nond 64 12 genomes genome NNS cord-282610-zim7nond 64 13 and and CC cord-282610-zim7nond 64 14 the the DT cord-282610-zim7nond 64 15 human human JJ cord-282610-zim7nond 64 16 genome genome NN cord-282610-zim7nond 64 17 continually continually RB cord-282610-zim7nond 64 18 interact interact VBP cord-282610-zim7nond 64 19 to to TO cord-282610-zim7nond 64 20 regulate regulate VB cord-282610-zim7nond 64 21 metabolism metabolism NN cord-282610-zim7nond 64 22 and and CC cord-282610-zim7nond 64 23 immunity immunity NN cord-282610-zim7nond 64 24 ( ( -LRB- cord-282610-zim7nond 64 25 15 15 CD cord-282610-zim7nond 64 26 , , , cord-282610-zim7nond 64 27 16 16 CD cord-282610-zim7nond 64 28 ) ) -RRB- cord-282610-zim7nond 64 29 . . . cord-282610-zim7nond 65 1 Early early JJ cord-282610-zim7nond 65 2 human human JJ cord-282610-zim7nond 65 3 microbiome microbiome NN cord-282610-zim7nond 65 4 studies study NNS cord-282610-zim7nond 65 5 characterized characterize VBD cord-282610-zim7nond 65 6 microbial microbial JJ cord-282610-zim7nond 65 7 ecosystems ecosystem NNS cord-282610-zim7nond 65 8 in in IN cord-282610-zim7nond 65 9 the the DT cord-282610-zim7nond 65 10 gut gut NN cord-282610-zim7nond 65 11 and and CC cord-282610-zim7nond 65 12 on on IN cord-282610-zim7nond 65 13 mucosal mucosal JJ cord-282610-zim7nond 65 14 surfaces surface NNS cord-282610-zim7nond 65 15 . . . cord-282610-zim7nond 66 1 However however RB cord-282610-zim7nond 66 2 , , , cord-282610-zim7nond 66 3 the the DT cord-282610-zim7nond 66 4 microbiome microbiome NN cord-282610-zim7nond 66 5 has have VBZ cord-282610-zim7nond 66 6 now now RB cord-282610-zim7nond 66 7 been be VBN cord-282610-zim7nond 66 8 shown show VBN cord-282610-zim7nond 66 9 to to TO cord-282610-zim7nond 66 10 extend extend VB cord-282610-zim7nond 66 11 to to IN cord-282610-zim7nond 66 12 nearly nearly RB cord-282610-zim7nond 66 13 every every DT cord-282610-zim7nond 66 14 human human JJ cord-282610-zim7nond 66 15 body body NN cord-282610-zim7nond 66 16 site site NN cord-282610-zim7nond 66 17 . . . cord-282610-zim7nond 67 1 These these DT cord-282610-zim7nond 67 2 include include VBP cord-282610-zim7nond 67 3 the the DT cord-282610-zim7nond 67 4 lungs lung NNS cord-282610-zim7nond 67 5 , , , cord-282610-zim7nond 67 6 the the DT cord-282610-zim7nond 67 7 bladder bladder NN cord-282610-zim7nond 67 8 , , , cord-282610-zim7nond 67 9 the the DT cord-282610-zim7nond 67 10 placenta placenta NN cord-282610-zim7nond 67 11 , , , cord-282610-zim7nond 67 12 the the DT cord-282610-zim7nond 67 13 testes testis NNS cord-282610-zim7nond 67 14 , , , cord-282610-zim7nond 67 15 and and CC cord-282610-zim7nond 67 16 the the DT cord-282610-zim7nond 67 17 uterus uterus NN cord-282610-zim7nond 67 18 [ [ -LRB- cord-282610-zim7nond 67 19 ( ( -LRB- cord-282610-zim7nond 67 20 19 19 CD cord-282610-zim7nond 67 21 , , , cord-282610-zim7nond 67 22 ( ( -LRB- cord-282610-zim7nond 67 23 30 30 CD cord-282610-zim7nond 67 24 ) ) -RRB- cord-282610-zim7nond 67 25 ( ( -LRB- cord-282610-zim7nond 67 26 31 31 CD cord-282610-zim7nond 67 27 ) ) -RRB- cord-282610-zim7nond 67 28 ( ( -LRB- cord-282610-zim7nond 67 29 32 32 CD cord-282610-zim7nond 67 30 ) ) -RRB- cord-282610-zim7nond 67 31 ( ( -LRB- cord-282610-zim7nond 67 32 33 33 CD cord-282610-zim7nond 67 33 ) ) -RRB- cord-282610-zim7nond 67 34 ] ] -RRB- cord-282610-zim7nond 67 35 . . . cord-282610-zim7nond 68 1 Jakobsen Jakobsen NNP cord-282610-zim7nond 68 2 et et NNP cord-282610-zim7nond 68 3 al al NNP cord-282610-zim7nond 68 4 . . . cord-282610-zim7nond 69 1 ( ( -LRB- cord-282610-zim7nond 69 2 35 35 CD cord-282610-zim7nond 69 3 ) ) -RRB- cord-282610-zim7nond 69 4 found find VBD cord-282610-zim7nond 69 5 that that IN cord-282610-zim7nond 69 6 previously previously RB cord-282610-zim7nond 69 7 sterile sterile JJ cord-282610-zim7nond 69 8 implants implant NNS cord-282610-zim7nond 69 9 removed remove VBN cord-282610-zim7nond 69 10 from from IN cord-282610-zim7nond 69 11 joints joint NNS cord-282610-zim7nond 69 12 , , , cord-282610-zim7nond 69 13 bones bone NNS cord-282610-zim7nond 69 14 , , , cord-282610-zim7nond 69 15 pacemakers pacemaker NNS cord-282610-zim7nond 69 16 , , , cord-282610-zim7nond 69 17 and and CC cord-282610-zim7nond 69 18 skulls skull NNS cord-282610-zim7nond 69 19 of of IN cord-282610-zim7nond 69 20 symptom symptom NN cord-282610-zim7nond 69 21 - - HYPH cord-282610-zim7nond 69 22 free free JJ cord-282610-zim7nond 69 23 patients patient NNS cord-282610-zim7nond 69 24 were be VBD cord-282610-zim7nond 69 25 colonized colonize VBN cord-282610-zim7nond 69 26 by by IN cord-282610-zim7nond 69 27 a a DT cord-282610-zim7nond 69 28 range range NN cord-282610-zim7nond 69 29 of of IN cord-282610-zim7nond 69 30 bacterial bacterial JJ cord-282610-zim7nond 69 31 and and CC cord-282610-zim7nond 69 32 fungal fungal JJ cord-282610-zim7nond 69 33 organisms organism NNS cord-282610-zim7nond 69 34 . . . cord-282610-zim7nond 70 1 Another another DT cord-282610-zim7nond 70 2 study study NN cord-282610-zim7nond 70 3 demonstrated demonstrate VBD cord-282610-zim7nond 70 4 the the DT cord-282610-zim7nond 70 5 presence presence NN cord-282610-zim7nond 70 6 of of IN cord-282610-zim7nond 70 7 novel novel JJ cord-282610-zim7nond 70 8 tissue tissue NN cord-282610-zim7nond 70 9 specific specific JJ cord-282610-zim7nond 70 10 bacterial bacterial JJ cord-282610-zim7nond 70 11 DNA dna NN cord-282610-zim7nond 70 12 profiles profile NNS cord-282610-zim7nond 70 13 in in IN cord-282610-zim7nond 70 14 a a DT cord-282610-zim7nond 70 15 variety variety NN cord-282610-zim7nond 70 16 of of IN cord-282610-zim7nond 70 17 mouse mouse NN cord-282610-zim7nond 70 18 organs organ NNS cord-282610-zim7nond 70 19 including include VBG cord-282610-zim7nond 70 20 the the DT cord-282610-zim7nond 70 21 brain brain NN cord-282610-zim7nond 70 22 , , , cord-282610-zim7nond 70 23 heart heart NN cord-282610-zim7nond 70 24 , , , cord-282610-zim7nond 70 25 liver liver NN cord-282610-zim7nond 70 26 , , , cord-282610-zim7nond 70 27 muscle muscle NN cord-282610-zim7nond 70 28 and and CC cord-282610-zim7nond 70 29 adipose adipose JJ cord-282610-zim7nond 70 30 tissue tissue NN cord-282610-zim7nond 70 31 ( ( -LRB- cord-282610-zim7nond 70 32 36 36 CD cord-282610-zim7nond 70 33 ) ) -RRB- cord-282610-zim7nond 70 34 . . . cord-282610-zim7nond 71 1 Microbial microbial JJ cord-282610-zim7nond 71 2 communities community NNS cord-282610-zim7nond 71 3 also also RB cord-282610-zim7nond 71 4 appear appear VBP cord-282610-zim7nond 71 5 to to TO cord-282610-zim7nond 71 6 persist persist VB cord-282610-zim7nond 71 7 in in IN cord-282610-zim7nond 71 8 healthy healthy JJ cord-282610-zim7nond 71 9 human human JJ cord-282610-zim7nond 71 10 blood blood NN cord-282610-zim7nond 71 11 ( ( -LRB- cord-282610-zim7nond 71 12 37 37 CD cord-282610-zim7nond 71 13 ) ) -RRB- cord-282610-zim7nond 71 14 ( ( -LRB- cord-282610-zim7nond 71 15 38 38 CD cord-282610-zim7nond 71 16 ) ) -RRB- cord-282610-zim7nond 71 17 ( ( -LRB- cord-282610-zim7nond 71 18 39 39 CD cord-282610-zim7nond 71 19 ) ) -RRB- cord-282610-zim7nond 71 20 . . . cord-282610-zim7nond 72 1 A a DT cord-282610-zim7nond 72 2 DNA dna NN cord-282610-zim7nond 72 3 virome virome NN cord-282610-zim7nond 72 4 was be VBD cord-282610-zim7nond 72 5 recently recently RB cord-282610-zim7nond 72 6 identified identify VBN cord-282610-zim7nond 72 7 in in IN cord-282610-zim7nond 72 8 healthy healthy JJ cord-282610-zim7nond 72 9 human human JJ cord-282610-zim7nond 72 10 blood blood NN cord-282610-zim7nond 72 11 ( ( -LRB- cord-282610-zim7nond 72 12 40 40 CD cord-282610-zim7nond 72 13 ) ) -RRB- cord-282610-zim7nond 72 14 . . . cord-282610-zim7nond 73 1 Another another DT cord-282610-zim7nond 73 2 study study NN cord-282610-zim7nond 73 3 reported report VBD cord-282610-zim7nond 73 4 both both DT cord-282610-zim7nond 73 5 bacterial bacterial JJ cord-282610-zim7nond 73 6 and and CC cord-282610-zim7nond 73 7 fungal fungal JJ cord-282610-zim7nond 73 8 communities community NNS cord-282610-zim7nond 73 9 in in IN cord-282610-zim7nond 73 10 the the DT cord-282610-zim7nond 73 11 blood blood NN cord-282610-zim7nond 73 12 of of IN cord-282610-zim7nond 73 13 healthy healthy JJ cord-282610-zim7nond 73 14 subjects subject NNS cord-282610-zim7nond 73 15 . . . cord-282610-zim7nond 74 1 Analysis analysis NN cord-282610-zim7nond 74 2 of of IN cord-282610-zim7nond 74 3 these these DT cord-282610-zim7nond 74 4 organisms organism NNS cord-282610-zim7nond 74 5 was be VBD cord-282610-zim7nond 74 6 performed perform VBN cord-282610-zim7nond 74 7 by by IN cord-282610-zim7nond 74 8 microbial microbial JJ cord-282610-zim7nond 74 9 resuscitation resuscitation NN cord-282610-zim7nond 74 10 of of IN cord-282610-zim7nond 74 11 blood blood NN cord-282610-zim7nond 74 12 culturing culturing NN cord-282610-zim7nond 74 13 and and CC cord-282610-zim7nond 74 14 microscopy microscopy NN cord-282610-zim7nond 74 15 in in IN cord-282610-zim7nond 74 16 addition addition NN cord-282610-zim7nond 74 17 to to IN cord-282610-zim7nond 74 18 next next JJ cord-282610-zim7nond 74 19 generation generation NN cord-282610-zim7nond 74 20 DNA dna NN cord-282610-zim7nond 74 21 sequencing sequencing NN cord-282610-zim7nond 74 22 ( ( -LRB- cord-282610-zim7nond 74 23 41 41 CD cord-282610-zim7nond 74 24 ) ) -RRB- cord-282610-zim7nond 74 25 . . . cord-282610-zim7nond 75 1 Whittle Whittle NNP cord-282610-zim7nond 75 2 et et NNP cord-282610-zim7nond 75 3 al al NNP cord-282610-zim7nond 75 4 . . . cord-282610-zim7nond 76 1 ( ( -LRB- cord-282610-zim7nond 76 2 42 42 CD cord-282610-zim7nond 76 3 ) ) -RRB- cord-282610-zim7nond 76 4 recently recently RB cord-282610-zim7nond 76 5 characterized characterize VBD cord-282610-zim7nond 76 6 a a DT cord-282610-zim7nond 76 7 human human JJ cord-282610-zim7nond 76 8 blood blood NN cord-282610-zim7nond 76 9 microbiome microbiome NN cord-282610-zim7nond 76 10 using use VBG cord-282610-zim7nond 76 11 a a DT cord-282610-zim7nond 76 12 range range NN cord-282610-zim7nond 76 13 of of IN cord-282610-zim7nond 76 14 complementary complementary JJ cord-282610-zim7nond 76 15 molecular molecular JJ cord-282610-zim7nond 76 16 and and CC cord-282610-zim7nond 76 17 classical classical JJ cord-282610-zim7nond 76 18 molecular molecular JJ cord-282610-zim7nond 76 19 biology biology NN cord-282610-zim7nond 76 20 techniques technique NNS cord-282610-zim7nond 76 21 . . . cord-282610-zim7nond 77 1 Another another DT cord-282610-zim7nond 77 2 study study NN cord-282610-zim7nond 77 3 identified identify VBD cord-282610-zim7nond 77 4 a a DT cord-282610-zim7nond 77 5 larger large JJR cord-282610-zim7nond 77 6 amount amount NN cord-282610-zim7nond 77 7 of of IN cord-282610-zim7nond 77 8 bacterial bacterial JJ cord-282610-zim7nond 77 9 rDNA rdna NN cord-282610-zim7nond 77 10 in in IN cord-282610-zim7nond 77 11 blood blood NN cord-282610-zim7nond 77 12 specimens specimen NNS cord-282610-zim7nond 77 13 from from IN cord-282610-zim7nond 77 14 healthy healthy JJ cord-282610-zim7nond 77 15 individuals individual NNS cord-282610-zim7nond 77 16 than than IN cord-282610-zim7nond 77 17 in in IN cord-282610-zim7nond 77 18 matched match VBN cord-282610-zim7nond 77 19 reagent reagent NN cord-282610-zim7nond 77 20 controls control NNS cord-282610-zim7nond 77 21 ( ( -LRB- cord-282610-zim7nond 77 22 24 24 CD cord-282610-zim7nond 77 23 ) ) -RRB- cord-282610-zim7nond 77 24 . . . cord-282610-zim7nond 78 1 Kowarsky Kowarsky NNP cord-282610-zim7nond 78 2 et et FW cord-282610-zim7nond 78 3 al al NNP cord-282610-zim7nond 78 4 . . . cord-282610-zim7nond 79 1 ( ( -LRB- cord-282610-zim7nond 79 2 14 14 CD cord-282610-zim7nond 79 3 ) ) -RRB- cord-282610-zim7nond 79 4 detected detect VBD cord-282610-zim7nond 79 5 over over IN cord-282610-zim7nond 79 6 3,000 3,000 CD cord-282610-zim7nond 79 7 previously previously RB cord-282610-zim7nond 79 8 unidentified unidentified JJ cord-282610-zim7nond 79 9 viruses virus NNS cord-282610-zim7nond 79 10 , , , cord-282610-zim7nond 79 11 bacteria bacteria NNS cord-282610-zim7nond 79 12 , , , cord-282610-zim7nond 79 13 and and CC cord-282610-zim7nond 79 14 fungi fungus NNS cord-282610-zim7nond 79 15 in in IN cord-282610-zim7nond 79 16 human human JJ cord-282610-zim7nond 79 17 blood blood NN cord-282610-zim7nond 79 18 samples sample NNS cord-282610-zim7nond 79 19 obtained obtain VBN cord-282610-zim7nond 79 20 from from IN cord-282610-zim7nond 79 21 immunocompromised immunocompromised JJ cord-282610-zim7nond 79 22 patients patient NNS cord-282610-zim7nond 79 23 . . . cord-282610-zim7nond 80 1 The the DT cord-282610-zim7nond 80 2 study study NN cord-282610-zim7nond 80 3 almost almost RB cord-282610-zim7nond 80 4 doubled double VBD cord-282610-zim7nond 80 5 the the DT cord-282610-zim7nond 80 6 total total JJ cord-282610-zim7nond 80 7 number number NN cord-282610-zim7nond 80 8 of of IN cord-282610-zim7nond 80 9 anelloviruses anelloviruse NNS cord-282610-zim7nond 80 10 found find VBN cord-282610-zim7nond 80 11 in in IN cord-282610-zim7nond 80 12 humans human NNS cord-282610-zim7nond 80 13 . . . cord-282610-zim7nond 81 1 In in IN cord-282610-zim7nond 81 2 order order NN cord-282610-zim7nond 81 3 to to TO cord-282610-zim7nond 81 4 classify classify VB cord-282610-zim7nond 81 5 many many JJ cord-282610-zim7nond 81 6 of of IN cord-282610-zim7nond 81 7 these these DT cord-282610-zim7nond 81 8 organisms organism NNS cord-282610-zim7nond 81 9 the the DT cord-282610-zim7nond 81 10 team team NN cord-282610-zim7nond 81 11 was be VBD cord-282610-zim7nond 81 12 forced force VBN cord-282610-zim7nond 81 13 to to TO cord-282610-zim7nond 81 14 add add VB cord-282610-zim7nond 81 15 new new JJ cord-282610-zim7nond 81 16 branches branch NNS cord-282610-zim7nond 81 17 to to IN cord-282610-zim7nond 81 18 the the DT cord-282610-zim7nond 81 19 " " `` cord-282610-zim7nond 81 20 tree tree NN cord-282610-zim7nond 81 21 of of IN cord-282610-zim7nond 81 22 life life NN cord-282610-zim7nond 81 23 . . . cord-282610-zim7nond 82 1 " " '' cord-282610-zim7nond 83 1 They -PRON- PRP cord-282610-zim7nond 83 2 concluded conclude VBD cord-282610-zim7nond 83 3 that that IN cord-282610-zim7nond 83 4 the the DT cord-282610-zim7nond 83 5 newly newly RB cord-282610-zim7nond 83 6 discovered discover VBN cord-282610-zim7nond 83 7 microbes microbe NNS cord-282610-zim7nond 83 8 " " `` cord-282610-zim7nond 83 9 may may MD cord-282610-zim7nond 83 10 prove prove VB cord-282610-zim7nond 83 11 to to TO cord-282610-zim7nond 83 12 be be VB cord-282610-zim7nond 83 13 the the DT cord-282610-zim7nond 83 14 cause cause NN cord-282610-zim7nond 83 15 of of IN cord-282610-zim7nond 83 16 acute acute JJ cord-282610-zim7nond 83 17 or or CC cord-282610-zim7nond 83 18 chronic chronic JJ cord-282610-zim7nond 83 19 diseases disease NNS cord-282610-zim7nond 83 20 that that WDT cord-282610-zim7nond 83 21 , , , cord-282610-zim7nond 83 22 to to IN cord-282610-zim7nond 83 23 date date NN cord-282610-zim7nond 83 24 , , , cord-282610-zim7nond 83 25 have have VBP cord-282610-zim7nond 83 26 unknown unknown JJ cord-282610-zim7nond 83 27 etiology etiology NN cord-282610-zim7nond 83 28 . . . cord-282610-zim7nond 83 29 " " '' cord-282610-zim7nond 84 1 The the DT cord-282610-zim7nond 84 2 microbiome microbiome NN cord-282610-zim7nond 84 3 is be VBZ cord-282610-zim7nond 84 4 inherited inherit VBN cord-282610-zim7nond 84 5 and and CC cord-282610-zim7nond 84 6 evolves evolve VBZ cord-282610-zim7nond 84 7 with with IN cord-282610-zim7nond 84 8 the the DT cord-282610-zim7nond 84 9 host host NN cord-282610-zim7nond 84 10 . . . cord-282610-zim7nond 85 1 Babies baby NNS cord-282610-zim7nond 85 2 are be VBP cord-282610-zim7nond 85 3 seeded seed VBN cord-282610-zim7nond 85 4 in in IN cord-282610-zim7nond 85 5 the the DT cord-282610-zim7nond 85 6 womb womb NN cord-282610-zim7nond 85 7 , , , cord-282610-zim7nond 85 8 during during IN cord-282610-zim7nond 85 9 birth birth NN cord-282610-zim7nond 85 10 , , , cord-282610-zim7nond 85 11 and and CC cord-282610-zim7nond 85 12 after after IN cord-282610-zim7nond 85 13 birth birth NN cord-282610-zim7nond 85 14 by by IN cord-282610-zim7nond 85 15 extensive extensive JJ cord-282610-zim7nond 85 16 microbiome microbiome NN cord-282610-zim7nond 85 17 communities community NNS cord-282610-zim7nond 85 18 in in IN cord-282610-zim7nond 85 19 the the DT cord-282610-zim7nond 85 20 placenta placenta NN cord-282610-zim7nond 85 21 , , , cord-282610-zim7nond 85 22 the the DT cord-282610-zim7nond 85 23 vaginal vaginal JJ cord-282610-zim7nond 85 24 canal canal NN cord-282610-zim7nond 85 25 , , , cord-282610-zim7nond 85 26 and and CC cord-282610-zim7nond 85 27 breast breast NN cord-282610-zim7nond 85 28 milk milk NN cord-282610-zim7nond 85 29 , , , cord-282610-zim7nond 85 30 among among IN cord-282610-zim7nond 85 31 other other JJ cord-282610-zim7nond 85 32 body body NN cord-282610-zim7nond 85 33 sites site NNS cord-282610-zim7nond 85 34 ( ( -LRB- cord-282610-zim7nond 85 35 43 43 CD cord-282610-zim7nond 85 36 , , , cord-282610-zim7nond 85 37 44 44 CD cord-282610-zim7nond 85 38 ) ) -RRB- cord-282610-zim7nond 85 39 . . . cord-282610-zim7nond 86 1 Microbes microbe NNS cord-282610-zim7nond 86 2 / / SYM cord-282610-zim7nond 86 3 pathogens pathogen NNS cord-282610-zim7nond 86 4 acquired acquire VBN cord-282610-zim7nond 86 5 from from IN cord-282610-zim7nond 86 6 the the DT cord-282610-zim7nond 86 7 external external JJ cord-282610-zim7nond 86 8 environment environment NN cord-282610-zim7nond 86 9 are be VBP cord-282610-zim7nond 86 10 further further RB cord-282610-zim7nond 86 11 incorporated incorporate VBN cord-282610-zim7nond 86 12 into into IN cord-282610-zim7nond 86 13 the the DT cord-282610-zim7nond 86 14 microbiome microbiome NN cord-282610-zim7nond 86 15 over over IN cord-282610-zim7nond 86 16 time time NN cord-282610-zim7nond 86 17 . . . cord-282610-zim7nond 87 1 For for IN cord-282610-zim7nond 87 2 example example NN cord-282610-zim7nond 87 3 , , , cord-282610-zim7nond 87 4 once once RB cord-282610-zim7nond 87 5 acquired acquire VBN cord-282610-zim7nond 87 6 , , , cord-282610-zim7nond 87 7 Cytomegalovirus Cytomegalovirus NNP cord-282610-zim7nond 87 8 persists persist VBZ cord-282610-zim7nond 87 9 as as IN cord-282610-zim7nond 87 10 a a DT cord-282610-zim7nond 87 11 member member NN cord-282610-zim7nond 87 12 of of IN cord-282610-zim7nond 87 13 the the DT cord-282610-zim7nond 87 14 microbiomewith microbiomewith NNP cord-282610-zim7nond 87 15 a a DT cord-282610-zim7nond 87 16 significant significant JJ cord-282610-zim7nond 87 17 impact impact NN cord-282610-zim7nond 87 18 on on IN cord-282610-zim7nond 87 19 host host NN cord-282610-zim7nond 87 20 immunity immunity NN cord-282610-zim7nond 87 21 . . . cord-282610-zim7nond 88 1 Brodin Brodin NNP cord-282610-zim7nond 88 2 et et NNP cord-282610-zim7nond 88 3 al al NNP cord-282610-zim7nond 88 4 . . . cord-282610-zim7nond 89 1 ( ( -LRB- cord-282610-zim7nond 89 2 45 45 CD cord-282610-zim7nond 89 3 ) ) -RRB- cord-282610-zim7nond 89 4 found find VBD cord-282610-zim7nond 89 5 that that IN cord-282610-zim7nond 89 6 the the DT cord-282610-zim7nond 89 7 lifelong lifelong JJ cord-282610-zim7nond 89 8 need need NN cord-282610-zim7nond 89 9 for for IN cord-282610-zim7nond 89 10 the the DT cord-282610-zim7nond 89 11 body body NN cord-282610-zim7nond 89 12 to to TO cord-282610-zim7nond 89 13 control control VB cord-282610-zim7nond 89 14 CMV CMV NNP cord-282610-zim7nond 89 15 causes cause NNS cord-282610-zim7nond 89 16 approximately approximately RB cord-282610-zim7nond 89 17 10 10 CD cord-282610-zim7nond 89 18 % % NN cord-282610-zim7nond 89 19 of of IN cord-282610-zim7nond 89 20 all all DT cord-282610-zim7nond 89 21 T t NN cord-282610-zim7nond 89 22 cells cell NNS cord-282610-zim7nond 89 23 in in IN cord-282610-zim7nond 89 24 CMV+ CMV+ NNP cord-282610-zim7nond 89 25 individuals individual NNS cord-282610-zim7nond 89 26 to to TO cord-282610-zim7nond 89 27 be be VB cord-282610-zim7nond 89 28 directed direct VBN cord-282610-zim7nond 89 29 against against IN cord-282610-zim7nond 89 30 the the DT cord-282610-zim7nond 89 31 virus virus NN cord-282610-zim7nond 89 32 . . . cord-282610-zim7nond 90 1 Immune immune JJ cord-282610-zim7nond 90 2 cells cell NNS cord-282610-zim7nond 90 3 and and CC cord-282610-zim7nond 90 4 associated associate VBN cord-282610-zim7nond 90 5 microbes microbe NNS cord-282610-zim7nond 90 6 can can MD cord-282610-zim7nond 90 7 travel travel VB cord-282610-zim7nond 90 8 between between IN cord-282610-zim7nond 90 9 the the DT cord-282610-zim7nond 90 10 human human JJ cord-282610-zim7nond 90 11 body body NN cord-282610-zim7nond 90 12 and and CC cord-282610-zim7nond 90 13 brain brain NN cord-282610-zim7nond 90 14 via via IN cord-282610-zim7nond 90 15 several several JJ cord-282610-zim7nond 90 16 newly newly RB cord-282610-zim7nond 90 17 discovered discover VBN cord-282610-zim7nond 90 18 pathways pathway NNS cord-282610-zim7nond 90 19 that that WDT cord-282610-zim7nond 90 20 bypass bypass VBP cord-282610-zim7nond 90 21 the the DT cord-282610-zim7nond 90 22 classical classical JJ cord-282610-zim7nond 90 23 blood blood NN cord-282610-zim7nond 90 24 - - HYPH cord-282610-zim7nond 90 25 brain brain NN cord-282610-zim7nond 90 26 barrier barrier NN cord-282610-zim7nond 90 27 ( ( -LRB- cord-282610-zim7nond 90 28 46 46 CD cord-282610-zim7nond 90 29 ) ) -RRB- cord-282610-zim7nond 90 30 . . . cord-282610-zim7nond 91 1 Benias Benias NNP cord-282610-zim7nond 91 2 et et NNP cord-282610-zim7nond 91 3 al al NNP cord-282610-zim7nond 91 4 . . . cord-282610-zim7nond 92 1 ( ( -LRB- cord-282610-zim7nond 92 2 47 47 CD cord-282610-zim7nond 92 3 ) ) -RRB- cord-282610-zim7nond 92 4 documented document VBD cord-282610-zim7nond 92 5 a a DT cord-282610-zim7nond 92 6 previously previously RB cord-282610-zim7nond 92 7 uncharacterized uncharacterized JJ cord-282610-zim7nond 92 8 fluidfilled fluidfille VBN cord-282610-zim7nond 92 9 lattice lattice NN cord-282610-zim7nond 92 10 of of IN cord-282610-zim7nond 92 11 collagen collagen NN cord-282610-zim7nond 92 12 bundles bundle NNS cord-282610-zim7nond 92 13 that that WDT cord-282610-zim7nond 92 14 appears appear VBZ cord-282610-zim7nond 92 15 to to TO cord-282610-zim7nond 92 16 connect connect VB cord-282610-zim7nond 92 17 all all DT cord-282610-zim7nond 92 18 human human JJ cord-282610-zim7nond 92 19 tissues tissue NNS cord-282610-zim7nond 92 20 . . . cord-282610-zim7nond 93 1 This this DT cord-282610-zim7nond 93 2 human human JJ cord-282610-zim7nond 93 3 interstitium interstitium NN cord-282610-zim7nond 93 4 drains drain VBZ cord-282610-zim7nond 93 5 directly directly RB cord-282610-zim7nond 93 6 into into IN cord-282610-zim7nond 93 7 the the DT cord-282610-zim7nond 93 8 lymph lymph NN cord-282610-zim7nond 93 9 nodes node NNS cord-282610-zim7nond 93 10 . . . cord-282610-zim7nond 94 1 Two two CD cord-282610-zim7nond 94 2 research research NN cord-282610-zim7nond 94 3 teams team NNS cord-282610-zim7nond 94 4 have have VBP cord-282610-zim7nond 94 5 demonstrated demonstrate VBN cord-282610-zim7nond 94 6 the the DT cord-282610-zim7nond 94 7 existence existence NN cord-282610-zim7nond 94 8 of of IN cord-282610-zim7nond 94 9 a a DT cord-282610-zim7nond 94 10 previously previously RB cord-282610-zim7nond 94 11 undiscovered undiscovered JJ cord-282610-zim7nond 94 12 meningeal meningeal JJ cord-282610-zim7nond 94 13 lymphatic lymphatic NN cord-282610-zim7nond 94 14 system system NN cord-282610-zim7nond 94 15 ( ( -LRB- cord-282610-zim7nond 94 16 46 46 CD cord-282610-zim7nond 94 17 , , , cord-282610-zim7nond 94 18 48 48 CD cord-282610-zim7nond 94 19 , , , cord-282610-zim7nond 94 20 49 49 CD cord-282610-zim7nond 94 21 ) ) -RRB- cord-282610-zim7nond 94 22 . . . cord-282610-zim7nond 95 1 The the DT cord-282610-zim7nond 95 2 network network NN cord-282610-zim7nond 95 3 's 's POS cord-282610-zim7nond 95 4 fluid fluid JJ cord-282610-zim7nond 95 5 pathways pathway NNS cord-282610-zim7nond 95 6 connect connect VBP cord-282610-zim7nond 95 7 the the DT cord-282610-zim7nond 95 8 cerebrospinal cerebrospinal JJ cord-282610-zim7nond 95 9 fluid fluid NN cord-282610-zim7nond 95 10 and and CC cord-282610-zim7nond 95 11 cervical cervical JJ cord-282610-zim7nond 95 12 lymph lymph NN cord-282610-zim7nond 95 13 nodes node NNS cord-282610-zim7nond 95 14 directly directly RB cord-282610-zim7nond 95 15 to to IN cord-282610-zim7nond 95 16 the the DT cord-282610-zim7nond 95 17 brain brain NN cord-282610-zim7nond 95 18 . . . cord-282610-zim7nond 96 1 While while IN cord-282610-zim7nond 96 2 great great JJ cord-282610-zim7nond 96 3 progress progress NN cord-282610-zim7nond 96 4 has have VBZ cord-282610-zim7nond 96 5 been be VBN cord-282610-zim7nond 96 6 made make VBN cord-282610-zim7nond 96 7 in in IN cord-282610-zim7nond 96 8 characterizing characterize VBG cord-282610-zim7nond 96 9 the the DT cord-282610-zim7nond 96 10 human human JJ cord-282610-zim7nond 96 11 microbiome microbiome NN cord-282610-zim7nond 96 12 , , , cord-282610-zim7nond 96 13 our -PRON- PRP$ cord-282610-zim7nond 96 14 understanding understanding NN cord-282610-zim7nond 96 15 of of IN cord-282610-zim7nond 96 16 the the DT cord-282610-zim7nond 96 17 body body NN cord-282610-zim7nond 96 18 's 's POS cord-282610-zim7nond 96 19 microbial microbial JJ cord-282610-zim7nond 96 20 ecosystems ecosystem NNS cord-282610-zim7nond 96 21 is be VBZ cord-282610-zim7nond 96 22 still still RB cord-282610-zim7nond 96 23 in in IN cord-282610-zim7nond 96 24 its -PRON- PRP$ cord-282610-zim7nond 96 25 infancy infancy NN cord-282610-zim7nond 96 26 . . . cord-282610-zim7nond 97 1 Metagenomic Metagenomic NNP cord-282610-zim7nond 97 2 analyses analysis NNS cord-282610-zim7nond 97 3 of of IN cord-282610-zim7nond 97 4 the the DT cord-282610-zim7nond 97 5 microbiome microbiome NN cord-282610-zim7nond 97 6 in in IN cord-282610-zim7nond 97 7 all all DT cord-282610-zim7nond 97 8 body body NN cord-282610-zim7nond 97 9 sites site NNS cord-282610-zim7nond 97 10 regularly regularly RB cord-282610-zim7nond 97 11 identify identify VBP cord-282610-zim7nond 97 12 species specie NNS cord-282610-zim7nond 97 13 or or CC cord-282610-zim7nond 97 14 strains strain NNS cord-282610-zim7nond 97 15 of of IN cord-282610-zim7nond 97 16 bacteria bacteria NNS cord-282610-zim7nond 97 17 , , , cord-282610-zim7nond 97 18 archaea archaea NNS cord-282610-zim7nond 97 19 , , , cord-282610-zim7nond 97 20 fungi fungus NNS cord-282610-zim7nond 97 21 , , , cord-282610-zim7nond 97 22 and/or and/or CC cord-282610-zim7nond 97 23 viruses virus NNS cord-282610-zim7nond 97 24 not not RB cord-282610-zim7nond 97 25 previously previously RB cord-282610-zim7nond 97 26 understood understand VBN cord-282610-zim7nond 97 27 to to TO cord-282610-zim7nond 97 28 persist persist VB cord-282610-zim7nond 97 29 in in IN cord-282610-zim7nond 97 30 Homo homo NN cord-282610-zim7nond 98 1 sapiens sapiens NNP cord-282610-zim7nond 98 2 ( ( -LRB- cord-282610-zim7nond 98 3 13 13 CD cord-282610-zim7nond 98 4 ) ) -RRB- cord-282610-zim7nond 98 5 . . . cord-282610-zim7nond 99 1 For for IN cord-282610-zim7nond 99 2 example example NN cord-282610-zim7nond 99 3 , , , cord-282610-zim7nond 99 4 just just RB cord-282610-zim7nond 99 5 one one CD cord-282610-zim7nond 99 6 study study NN cord-282610-zim7nond 99 7 of of IN cord-282610-zim7nond 99 8 the the DT cord-282610-zim7nond 99 9 bladder bladder NN cord-282610-zim7nond 99 10 microbiome microbiome NN cord-282610-zim7nond 99 11 identified identify VBD cord-282610-zim7nond 99 12 129 129 CD cord-282610-zim7nond 99 13 previously previously RB cord-282610-zim7nond 99 14 unidentified unidentified JJ cord-282610-zim7nond 99 15 viruses virus NNS cord-282610-zim7nond 99 16 in in IN cord-282610-zim7nond 99 17 subjects subject NNS cord-282610-zim7nond 99 18 ' ' POS cord-282610-zim7nond 99 19 urine urine NN cord-282610-zim7nond 99 20 samples sample NNS cord-282610-zim7nond 99 21 ( ( -LRB- cord-282610-zim7nond 99 22 50 50 CD cord-282610-zim7nond 99 23 ) ) -RRB- cord-282610-zim7nond 99 24 . . . cord-282610-zim7nond 100 1 New new JJ cord-282610-zim7nond 100 2 strains strain NNS cord-282610-zim7nond 100 3 of of IN cord-282610-zim7nond 100 4 known know VBN cord-282610-zim7nond 100 5 microbes microbe NNS cord-282610-zim7nond 100 6 are be VBP cord-282610-zim7nond 100 7 also also RB cord-282610-zim7nond 100 8 regularly regularly RB cord-282610-zim7nond 100 9 identified identify VBN cord-282610-zim7nond 100 10 . . . cord-282610-zim7nond 101 1 For for IN cord-282610-zim7nond 101 2 example example NN cord-282610-zim7nond 101 3 , , , cord-282610-zim7nond 101 4 as as IN cord-282610-zim7nond 101 5 of of IN cord-282610-zim7nond 101 6 August August NNP cord-282610-zim7nond 101 7 2018 2018 CD cord-282610-zim7nond 101 8 , , , cord-282610-zim7nond 101 9 the the DT cord-282610-zim7nond 101 10 NCBI NCBI NNP cord-282610-zim7nond 101 11 database database NN cord-282610-zim7nond 101 12 contains contain VBZ cord-282610-zim7nond 101 13 ∼1,833 ∼1,833 NNP cord-282610-zim7nond 101 14 Lactobacillus lactobacillus NN cord-282610-zim7nond 101 15 genomes genome NNS cord-282610-zim7nond 101 16 , , , cord-282610-zim7nond 101 17 with with IN cord-282610-zim7nond 101 18 newly newly RB cord-282610-zim7nond 101 19 characterized characterize VBN cord-282610-zim7nond 101 20 Lactobacillus lactobacillus NN cord-282610-zim7nond 101 21 genomes genome NNS cord-282610-zim7nond 101 22 added add VBN cord-282610-zim7nond 101 23 on on IN cord-282610-zim7nond 101 24 a a DT cord-282610-zim7nond 101 25 weekly weekly JJ cord-282610-zim7nond 101 26 basis basis NN cord-282610-zim7nond 101 27 ( ( -LRB- cord-282610-zim7nond 101 28 51 51 CD cord-282610-zim7nond 101 29 ) ) -RRB- cord-282610-zim7nond 101 30 . . . cord-282610-zim7nond 102 1 Successful successful JJ cord-282610-zim7nond 102 2 identification identification NN cord-282610-zim7nond 102 3 of of IN cord-282610-zim7nond 102 4 these these DT cord-282610-zim7nond 102 5 known know VBN cord-282610-zim7nond 102 6 or or CC cord-282610-zim7nond 102 7 novel novel JJ cord-282610-zim7nond 102 8 human human JJ cord-282610-zim7nond 102 9 organisms organism NNS cord-282610-zim7nond 102 10 hinges hinge NNS cord-282610-zim7nond 102 11 on on IN cord-282610-zim7nond 102 12 the the DT cord-282610-zim7nond 102 13 careful careful JJ cord-282610-zim7nond 102 14 choice choice NN cord-282610-zim7nond 102 15 of of IN cord-282610-zim7nond 102 16 technology technology NN cord-282610-zim7nond 102 17 and and CC cord-282610-zim7nond 102 18 methodology methodology NN cord-282610-zim7nond 102 19 used use VBN cord-282610-zim7nond 102 20 for for IN cord-282610-zim7nond 102 21 detection detection NN cord-282610-zim7nond 102 22 purposes purpose NNS cord-282610-zim7nond 102 23 ( ( -LRB- cord-282610-zim7nond 102 24 26 26 CD cord-282610-zim7nond 102 25 ) ) -RRB- cord-282610-zim7nond 102 26 . . . cord-282610-zim7nond 103 1 While while IN cord-282610-zim7nond 103 2 the the DT cord-282610-zim7nond 103 3 majority majority NN cord-282610-zim7nond 103 4 of of IN cord-282610-zim7nond 103 5 human human JJ cord-282610-zim7nond 103 6 microbiome microbiome NNP cord-282610-zim7nond 103 7 studies study NNS cord-282610-zim7nond 103 8 center center VBP cord-282610-zim7nond 103 9 on on IN cord-282610-zim7nond 103 10 bacteria bacteria NNS cord-282610-zim7nond 103 11 , , , cord-282610-zim7nond 103 12 awareness awareness NN cord-282610-zim7nond 103 13 of of IN cord-282610-zim7nond 103 14 viruses virus NNS cord-282610-zim7nond 103 15 , , , cord-282610-zim7nond 103 16 fungi fungus NNS cord-282610-zim7nond 103 17 , , , cord-282610-zim7nond 103 18 and and CC cord-282610-zim7nond 103 19 archaea archaea NNP cord-282610-zim7nond 103 20 has have VBZ cord-282610-zim7nond 103 21 increased increase VBN cord-282610-zim7nond 103 22 in in IN cord-282610-zim7nond 103 23 recent recent JJ cord-282610-zim7nond 103 24 years year NNS cord-282610-zim7nond 103 25 ( ( -LRB- cord-282610-zim7nond 103 26 52 52 CD cord-282610-zim7nond 103 27 ) ) -RRB- cord-282610-zim7nond 103 28 . . . cord-282610-zim7nond 104 1 For for IN cord-282610-zim7nond 104 2 example example NN cord-282610-zim7nond 104 3 , , , cord-282610-zim7nond 104 4 Manuela Manuela NNP cord-282610-zim7nond 104 5 et et NNP cord-282610-zim7nond 104 6 al al NNP cord-282610-zim7nond 104 7 . . . cord-282610-zim7nond 105 1 ( ( -LRB- cord-282610-zim7nond 105 2 53 53 CD cord-282610-zim7nond 105 3 ) ) -RRB- cord-282610-zim7nond 105 4 found find VBD cord-282610-zim7nond 105 5 an an DT cord-282610-zim7nond 105 6 almost almost RB cord-282610-zim7nond 105 7 1:1 1:1 CD cord-282610-zim7nond 105 8 ratio ratio NN cord-282610-zim7nond 105 9 of of IN cord-282610-zim7nond 105 10 archaeal archaeal JJ cord-282610-zim7nond 105 11 to to IN cord-282610-zim7nond 105 12 bacterial bacterial JJ cord-282610-zim7nond 105 13 16S 16S NNPS cord-282610-zim7nond 105 14 rRNA rRNA NNP cord-282610-zim7nond 105 15 genes gene NNS cord-282610-zim7nond 105 16 in in IN cord-282610-zim7nond 105 17 human human JJ cord-282610-zim7nond 105 18 appendix appendix NN cord-282610-zim7nond 105 19 and and CC cord-282610-zim7nond 105 20 nose nose NN cord-282610-zim7nond 105 21 samples sample NNS cord-282610-zim7nond 105 22 . . . cord-282610-zim7nond 106 1 Identification identification NN cord-282610-zim7nond 106 2 of of IN cord-282610-zim7nond 106 3 this this DT cord-282610-zim7nond 106 4 archaeome archaeome NN cord-282610-zim7nond 106 5 abundance abundance NN cord-282610-zim7nond 106 6 and and CC cord-282610-zim7nond 106 7 diversity diversity NN cord-282610-zim7nond 106 8 required require VBN cord-282610-zim7nond 106 9 use use NN cord-282610-zim7nond 106 10 of of IN cord-282610-zim7nond 106 11 a a DT cord-282610-zim7nond 106 12 very very RB cord-282610-zim7nond 106 13 specific specific JJ cord-282610-zim7nond 106 14 archaea archaea RB cord-282610-zim7nond 106 15 - - HYPH cord-282610-zim7nond 106 16 targeting target VBG cord-282610-zim7nond 106 17 methodology methodology NN cord-282610-zim7nond 106 18 . . . cord-282610-zim7nond 107 1 Viruses virus NNS cord-282610-zim7nond 107 2 are be VBP cord-282610-zim7nond 107 3 the the DT cord-282610-zim7nond 107 4 most most RBS cord-282610-zim7nond 107 5 abundant abundant JJ cord-282610-zim7nond 107 6 life life NN cord-282610-zim7nond 107 7 forms form NNS cord-282610-zim7nond 107 8 on on IN cord-282610-zim7nond 107 9 the the DT cord-282610-zim7nond 107 10 planet planet NN cord-282610-zim7nond 107 11 and and CC cord-282610-zim7nond 107 12 in in IN cord-282610-zim7nond 107 13 the the DT cord-282610-zim7nond 107 14 human human JJ cord-282610-zim7nond 107 15 body body NN cord-282610-zim7nond 107 16 , , , cord-282610-zim7nond 107 17 but but CC cord-282610-zim7nond 107 18 have have VBP cord-282610-zim7nond 107 19 been be VBN cord-282610-zim7nond 107 20 relatively relatively RB cord-282610-zim7nond 107 21 hard hard JJ cord-282610-zim7nond 107 22 to to TO cord-282610-zim7nond 107 23 detect detect VB cord-282610-zim7nond 107 24 until until IN cord-282610-zim7nond 107 25 very very RB cord-282610-zim7nond 107 26 recently recently RB cord-282610-zim7nond 107 27 ( ( -LRB- cord-282610-zim7nond 107 28 54 54 CD cord-282610-zim7nond 107 29 ) ) -RRB- cord-282610-zim7nond 107 30 . . . cord-282610-zim7nond 108 1 Viruses virus NNS cord-282610-zim7nond 108 2 that that WDT cord-282610-zim7nond 108 3 primarily primarily RB cord-282610-zim7nond 108 4 infect infect VBP cord-282610-zim7nond 108 5 bacteria bacteria NNS cord-282610-zim7nond 108 6 , , , cord-282610-zim7nond 108 7 called call VBN cord-282610-zim7nond 108 8 bacteriophages bacteriophage NNS cord-282610-zim7nond 108 9 , , , cord-282610-zim7nond 108 10 are be VBP cord-282610-zim7nond 108 11 particularly particularly RB cord-282610-zim7nond 108 12 abundant abundant JJ cord-282610-zim7nond 108 13 in in IN cord-282610-zim7nond 108 14 human human JJ cord-282610-zim7nond 108 15 microbiome microbiome NN cord-282610-zim7nond 108 16 communities community NNS cord-282610-zim7nond 108 17 . . . cord-282610-zim7nond 109 1 Nguyen Nguyen NNP cord-282610-zim7nond 109 2 et et NNP cord-282610-zim7nond 109 3 al al NNP cord-282610-zim7nond 109 4 . . . cord-282610-zim7nond 110 1 ( ( -LRB- cord-282610-zim7nond 110 2 55 55 CD cord-282610-zim7nond 110 3 ) ) -RRB- cord-282610-zim7nond 110 4 estimate estimate VBP cord-282610-zim7nond 110 5 that that IN cord-282610-zim7nond 110 6 ∼31 ∼31 NNP cord-282610-zim7nond 110 7 billion billion CD cord-282610-zim7nond 110 8 bacteriophages bacteriophage NNS cord-282610-zim7nond 110 9 traffic traffic VBP cord-282610-zim7nond 110 10 human human JJ cord-282610-zim7nond 110 11 tissue tissue NN cord-282610-zim7nond 110 12 and and CC cord-282610-zim7nond 110 13 blood blood NN cord-282610-zim7nond 110 14 on on IN cord-282610-zim7nond 110 15 a a DT cord-282610-zim7nond 110 16 daily daily JJ cord-282610-zim7nond 110 17 basis basis NN cord-282610-zim7nond 110 18 . . . cord-282610-zim7nond 111 1 However however RB cord-282610-zim7nond 111 2 , , , cord-282610-zim7nond 111 3 the the DT cord-282610-zim7nond 111 4 human human JJ cord-282610-zim7nond 111 5 virome virome NNP cord-282610-zim7nond 111 6 also also RB cord-282610-zim7nond 111 7 harbors harbor VBZ cord-282610-zim7nond 111 8 a a DT cord-282610-zim7nond 111 9 plethora plethora NN cord-282610-zim7nond 111 10 of of IN cord-282610-zim7nond 111 11 human human JJ cord-282610-zim7nond 111 12 - - HYPH cord-282610-zim7nond 111 13 associated associate VBN cord-282610-zim7nond 111 14 viruses virus NNS cord-282610-zim7nond 111 15 . . . cord-282610-zim7nond 112 1 Newberry Newberry NNP cord-282610-zim7nond 112 2 et et NNP cord-282610-zim7nond 112 3 al al NNP cord-282610-zim7nond 112 4 . . . cord-282610-zim7nond 113 1 ( ( -LRB- cord-282610-zim7nond 113 2 56 56 CD cord-282610-zim7nond 113 3 ) ) -RRB- cord-282610-zim7nond 113 4 are be VBP cord-282610-zim7nond 113 5 correct correct JJ cord-282610-zim7nond 113 6 to to TO cord-282610-zim7nond 113 7 assert assert VB cord-282610-zim7nond 113 8 that that IN cord-282610-zim7nond 113 9 this this DT cord-282610-zim7nond 113 10 human human JJ cord-282610-zim7nond 113 11 virome virome NN cord-282610-zim7nond 113 12 is be VBZ cord-282610-zim7nond 113 13 understudied understudied JJ cord-282610-zim7nond 113 14 in in IN cord-282610-zim7nond 113 15 ME ME NNP cord-282610-zim7nond 113 16 / / SYM cord-282610-zim7nond 113 17 CFS CFS NNP cord-282610-zim7nond 113 18 . . . cord-282610-zim7nond 114 1 Paez Paez NNP cord-282610-zim7nond 114 2 - - HYPH cord-282610-zim7nond 114 3 Espino Espino NNP cord-282610-zim7nond 114 4 et et NNP cord-282610-zim7nond 114 5 al al NNP cord-282610-zim7nond 114 6 . . . cord-282610-zim7nond 115 1 ( ( -LRB- cord-282610-zim7nond 115 2 57 57 CD cord-282610-zim7nond 115 3 ) ) -RRB- cord-282610-zim7nond 115 4 at at IN cord-282610-zim7nond 115 5 the the DT cord-282610-zim7nond 115 6 Joint Joint NNP cord-282610-zim7nond 115 7 Genome Genome NNP cord-282610-zim7nond 115 8 Institute Institute NNP cord-282610-zim7nond 115 9 have have VBP cord-282610-zim7nond 115 10 undertaken undertake VBN cord-282610-zim7nond 115 11 a a DT cord-282610-zim7nond 115 12 large large JJ cord-282610-zim7nond 115 13 project project NN cord-282610-zim7nond 115 14 called call VBN cord-282610-zim7nond 115 15 " " `` cord-282610-zim7nond 115 16 Uncovering uncover VBG cord-282610-zim7nond 115 17 the the DT cord-282610-zim7nond 115 18 Earth Earth NNP cord-282610-zim7nond 115 19 's 's POS cord-282610-zim7nond 115 20 Virome Virome NNP cord-282610-zim7nond 115 21 . . . cord-282610-zim7nond 116 1 " " '' cord-282610-zim7nond 117 1 The the DT cord-282610-zim7nond 117 2 Project Project NNP cord-282610-zim7nond 117 3 's 's POS cord-282610-zim7nond 117 4 goal goal NN cord-282610-zim7nond 117 5 is be VBZ cord-282610-zim7nond 117 6 to to TO cord-282610-zim7nond 117 7 better better RB cord-282610-zim7nond 117 8 identify identify VB cord-282610-zim7nond 117 9 known know VBN cord-282610-zim7nond 117 10 and and CC cord-282610-zim7nond 117 11 novel novel JJ cord-282610-zim7nond 117 12 viruses virus NNS cord-282610-zim7nond 117 13 in in IN cord-282610-zim7nond 117 14 Earth Earth NNP cord-282610-zim7nond 117 15 's 's POS cord-282610-zim7nond 117 16 ecosystems ecosystem NNS cord-282610-zim7nond 117 17 including include VBG cord-282610-zim7nond 117 18 the the DT cord-282610-zim7nond 117 19 human human JJ cord-282610-zim7nond 117 20 body body NN cord-282610-zim7nond 117 21 . . . cord-282610-zim7nond 118 1 Viral viral JJ cord-282610-zim7nond 118 2 identification identification NN cord-282610-zim7nond 118 3 requires require VBZ cord-282610-zim7nond 118 4 the the DT cord-282610-zim7nond 118 5 use use NN cord-282610-zim7nond 118 6 of of IN cord-282610-zim7nond 118 7 specific specific JJ cord-282610-zim7nond 118 8 metagenomic metagenomic JJ cord-282610-zim7nond 118 9 tools tool NNS cord-282610-zim7nond 118 10 , , , cord-282610-zim7nond 118 11 pipelines pipeline NNS cord-282610-zim7nond 118 12 , , , cord-282610-zim7nond 118 13 and and CC cord-282610-zim7nond 118 14 annotation annotation NN cord-282610-zim7nond 118 15 platforms platform NNS cord-282610-zim7nond 118 16 , , , cord-282610-zim7nond 118 17 with with IN cord-282610-zim7nond 118 18 findings finding NNS cord-282610-zim7nond 118 19 entered enter VBN cord-282610-zim7nond 118 20 in in IN cord-282610-zim7nond 118 21 the the DT cord-282610-zim7nond 118 22 JGI JGI NNP cord-282610-zim7nond 118 23 IMG IMG NNP cord-282610-zim7nond 118 24 / / SYM cord-282610-zim7nond 118 25 VR VR NNP cord-282610-zim7nond 118 26 Database Database NNP cord-282610-zim7nond 118 27 ( ( -LRB- cord-282610-zim7nond 118 28 57 57 CD cord-282610-zim7nond 118 29 ) ) -RRB- cord-282610-zim7nond 118 30 . . . cord-282610-zim7nond 119 1 The the DT cord-282610-zim7nond 119 2 Project Project NNP cord-282610-zim7nond 119 3 is be VBZ cord-282610-zim7nond 119 4 progressing progress VBG cord-282610-zim7nond 119 5 at at IN cord-282610-zim7nond 119 6 such such PDT cord-282610-zim7nond 119 7 a a DT cord-282610-zim7nond 119 8 rapid rapid JJ cord-282610-zim7nond 119 9 pace pace NN cord-282610-zim7nond 119 10 that that WDT cord-282610-zim7nond 119 11 viral viral JJ cord-282610-zim7nond 119 12 diversity diversity NN cord-282610-zim7nond 119 13 in in IN cord-282610-zim7nond 119 14 IMG IMG NNP cord-282610-zim7nond 119 15 / / SYM cord-282610-zim7nond 119 16 VR VR NNP cord-282610-zim7nond 119 17 has have VBZ cord-282610-zim7nond 119 18 more more JJR cord-282610-zim7nond 119 19 than than IN cord-282610-zim7nond 119 20 tripled triple VBN cord-282610-zim7nond 119 21 since since IN cord-282610-zim7nond 119 22 August August NNP cord-282610-zim7nond 119 23 2016 2016 CD cord-282610-zim7nond 119 24 ( ( -LRB- cord-282610-zim7nond 119 25 58 58 CD cord-282610-zim7nond 119 26 ) ) -RRB- cord-282610-zim7nond 119 27 , , , cord-282610-zim7nond 119 28 ( ( -LRB- cord-282610-zim7nond 119 29 Figure figure NN cord-282610-zim7nond 119 30 1 1 CD cord-282610-zim7nond 119 31 ) ) -RRB- cord-282610-zim7nond 119 32 . . . cord-282610-zim7nond 120 1 Nevertheless nevertheless RB cord-282610-zim7nond 120 2 , , , cord-282610-zim7nond 120 3 the the DT cord-282610-zim7nond 120 4 vast vast JJ cord-282610-zim7nond 120 5 majority majority NN cord-282610-zim7nond 120 6 of of IN cord-282610-zim7nond 120 7 the the DT cord-282610-zim7nond 120 8 gene gene NN cord-282610-zim7nond 120 9 content content NN cord-282610-zim7nond 120 10 ( ( -LRB- cord-282610-zim7nond 120 11 over over IN cord-282610-zim7nond 120 12 15 15 CD cord-282610-zim7nond 120 13 million million CD cord-282610-zim7nond 120 14 genes gene NNS cord-282610-zim7nond 120 15 in in IN cord-282610-zim7nond 120 16 total total NN cord-282610-zim7nond 120 17 ) ) -RRB- cord-282610-zim7nond 120 18 remains remain VBZ cord-282610-zim7nond 120 19 unknown unknown JJ cord-282610-zim7nond 120 20 or or CC cord-282610-zim7nond 120 21 hypothetical hypothetical JJ cord-282610-zim7nond 120 22 . . . cord-282610-zim7nond 121 1 We -PRON- PRP cord-282610-zim7nond 121 2 must must MD cord-282610-zim7nond 121 3 subsequently subsequently RB cord-282610-zim7nond 121 4 consider consider VB cord-282610-zim7nond 121 5 the the DT cord-282610-zim7nond 121 6 possibility possibility NN cord-282610-zim7nond 121 7 that that IN cord-282610-zim7nond 121 8 asyet asyet NNP cord-282610-zim7nond 121 9 unidentified unidentified JJ cord-282610-zim7nond 121 10 microorganisms microorganism NNS cord-282610-zim7nond 121 11 may may MD cord-282610-zim7nond 121 12 contribute contribute VB cord-282610-zim7nond 121 13 to to IN cord-282610-zim7nond 121 14 chronic chronic JJ cord-282610-zim7nond 121 15 inflammatory inflammatory JJ cord-282610-zim7nond 121 16 conditions condition NNS cord-282610-zim7nond 121 17 like like IN cord-282610-zim7nond 121 18 ME ME NNP cord-282610-zim7nond 121 19 / / SYM cord-282610-zim7nond 121 20 CFS CFS NNP cord-282610-zim7nond 121 21 . . . cord-282610-zim7nond 122 1 Failure failure NN cord-282610-zim7nond 122 2 to to TO cord-282610-zim7nond 122 3 do do VB cord-282610-zim7nond 122 4 so so RB cord-282610-zim7nond 122 5 would would MD cord-282610-zim7nond 122 6 be be VB cord-282610-zim7nond 122 7 akin akin JJ cord-282610-zim7nond 122 8 to to IN cord-282610-zim7nond 122 9 studying study VBG cord-282610-zim7nond 122 10 ∼2 ∼2 CD cord-282610-zim7nond 122 11 % % NN cord-282610-zim7nond 122 12 of of IN cord-282610-zim7nond 122 13 the the DT cord-282610-zim7nond 122 14 animals animal NNS cord-282610-zim7nond 122 15 in in IN cord-282610-zim7nond 122 16 the the DT cord-282610-zim7nond 122 17 rainforest rainforest NN cord-282610-zim7nond 122 18 and and CC cord-282610-zim7nond 122 19 arriving arrive VBG cord-282610-zim7nond 122 20 at at IN cord-282610-zim7nond 122 21 firm firm JJ cord-282610-zim7nond 122 22 conclusions conclusion NNS cord-282610-zim7nond 122 23 about about IN cord-282610-zim7nond 122 24 the the DT cord-282610-zim7nond 122 25 entire entire JJ cord-282610-zim7nond 122 26 ecosystem ecosystem NN cord-282610-zim7nond 122 27 based base VBN cord-282610-zim7nond 122 28 on on IN cord-282610-zim7nond 122 29 that that DT cord-282610-zim7nond 122 30 information information NN cord-282610-zim7nond 122 31 alone alone RB cord-282610-zim7nond 122 32 . . . cord-282610-zim7nond 123 1 Certain certain JJ cord-282610-zim7nond 123 2 members member NNS cord-282610-zim7nond 123 3 of of IN cord-282610-zim7nond 123 4 the the DT cord-282610-zim7nond 123 5 human human JJ cord-282610-zim7nond 123 6 microbiome microbiome NN cord-282610-zim7nond 123 7 may may MD cord-282610-zim7nond 123 8 also also RB cord-282610-zim7nond 123 9 be be VB cord-282610-zim7nond 123 10 difficult difficult JJ cord-282610-zim7nond 123 11 to to TO cord-282610-zim7nond 123 12 detect detect VB cord-282610-zim7nond 123 13 based base VBN cord-282610-zim7nond 123 14 on on IN cord-282610-zim7nond 123 15 their -PRON- PRP$ cord-282610-zim7nond 123 16 location location NN cord-282610-zim7nond 123 17 and/or and/or CC cord-282610-zim7nond 123 18 lifestyle lifestyle NN cord-282610-zim7nond 123 19 . . . cord-282610-zim7nond 124 1 For for IN cord-282610-zim7nond 124 2 example example NN cord-282610-zim7nond 124 3 , , , cord-282610-zim7nond 124 4 Chen Chen NNP cord-282610-zim7nond 124 5 et et NNP cord-282610-zim7nond 124 6 al al NNP cord-282610-zim7nond 124 7 . . . cord-282610-zim7nond 125 1 ( ( -LRB- cord-282610-zim7nond 125 2 59 59 CD cord-282610-zim7nond 125 3 ) ) -RRB- cord-282610-zim7nond 125 4 found find VBD cord-282610-zim7nond 125 5 that that IN cord-282610-zim7nond 125 6 elevated elevated JJ cord-282610-zim7nond 125 7 cytokine cytokine JJ cord-282610-zim7nond 125 8 expression expression NN cord-282610-zim7nond 125 9 in in IN cord-282610-zim7nond 125 10 response response NN cord-282610-zim7nond 125 11 to to IN cord-282610-zim7nond 125 12 HSV HSV NNP cord-282610-zim7nond 125 13 - - HYPH cord-282610-zim7nond 125 14 infected infect VBN cord-282610-zim7nond 125 15 peripheral peripheral JJ cord-282610-zim7nond 125 16 nerve nerve NN cord-282610-zim7nond 125 17 ganglia ganglion NNS cord-282610-zim7nond 125 18 persisted persist VBD cord-282610-zim7nond 125 19 even even RB cord-282610-zim7nond 125 20 when when WRB cord-282610-zim7nond 125 21 the the DT cord-282610-zim7nond 125 22 virus virus NN cord-282610-zim7nond 125 23 entered enter VBD cord-282610-zim7nond 125 24 a a DT cord-282610-zim7nond 125 25 latent latent JJ cord-282610-zim7nond 125 26 , , , cord-282610-zim7nond 125 27 non non JJ cord-282610-zim7nond 125 28 - - JJ cord-282610-zim7nond 125 29 replicating replicating JJ cord-282610-zim7nond 125 30 state state NN cord-282610-zim7nond 125 31 . . . cord-282610-zim7nond 126 1 While while IN cord-282610-zim7nond 126 2 it -PRON- PRP cord-282610-zim7nond 126 3 is be VBZ cord-282610-zim7nond 126 4 important important JJ cord-282610-zim7nond 126 5 to to TO cord-282610-zim7nond 126 6 pursue pursue VB cord-282610-zim7nond 126 7 identification identification NN cord-282610-zim7nond 126 8 of of IN cord-282610-zim7nond 126 9 novel novel JJ cord-282610-zim7nond 126 10 organisms organism NNS cord-282610-zim7nond 126 11 in in IN cord-282610-zim7nond 126 12 ME ME NNP cord-282610-zim7nond 126 13 / / SYM cord-282610-zim7nond 126 14 CFS CFS NNP cord-282610-zim7nond 126 15 blood blood NN cord-282610-zim7nond 126 16 and and CC cord-282610-zim7nond 126 17 tissue tissue NN cord-282610-zim7nond 126 18 , , , cord-282610-zim7nond 126 19 ample ample JJ cord-282610-zim7nond 126 20 data datum NNS cord-282610-zim7nond 126 21 already already RB cord-282610-zim7nond 126 22 exists exist VBZ cord-282610-zim7nond 126 23 on on IN cord-282610-zim7nond 126 24 better well RBR cord-282610-zim7nond 126 25 - - HYPH cord-282610-zim7nond 126 26 studied study VBN cord-282610-zim7nond 126 27 components component NNS cord-282610-zim7nond 126 28 of of IN cord-282610-zim7nond 126 29 the the DT cord-282610-zim7nond 126 30 microbiome microbiome NN cord-282610-zim7nond 126 31 . . . cord-282610-zim7nond 127 1 Microbial microbial JJ cord-282610-zim7nond 127 2 and and CC cord-282610-zim7nond 127 3 viral viral JJ cord-282610-zim7nond 127 4 survival survival NN cord-282610-zim7nond 127 5 strategies strategy NNS cord-282610-zim7nond 127 6 , , , cord-282610-zim7nond 127 7 virulence virulence NN cord-282610-zim7nond 127 8 mechanisms mechanism NNS cord-282610-zim7nond 127 9 and and CC cord-282610-zim7nond 127 10 collective collective JJ cord-282610-zim7nond 127 11 behaviors behavior NNS cord-282610-zim7nond 127 12 are be VBP cord-282610-zim7nond 127 13 also also RB cord-282610-zim7nond 127 14 characterized characterize VBN cord-282610-zim7nond 127 15 by by IN cord-282610-zim7nond 127 16 a a DT cord-282610-zim7nond 127 17 high high JJ cord-282610-zim7nond 127 18 degree degree NN cord-282610-zim7nond 127 19 of of IN cord-282610-zim7nond 127 20 functional functional JJ cord-282610-zim7nond 127 21 redundancy redundancy NN cord-282610-zim7nond 127 22 ( ( -LRB- cord-282610-zim7nond 127 23 60 60 CD cord-282610-zim7nond 127 24 , , , cord-282610-zim7nond 127 25 61 61 CD cord-282610-zim7nond 127 26 ) ) -RRB- cord-282610-zim7nond 127 27 . . . cord-282610-zim7nond 128 1 We -PRON- PRP cord-282610-zim7nond 128 2 must must MD cord-282610-zim7nond 128 3 accept accept VB cord-282610-zim7nond 128 4 the the DT cord-282610-zim7nond 128 5 complexity complexity NN cord-282610-zim7nond 128 6 inherent inherent JJ cord-282610-zim7nond 128 7 to to IN cord-282610-zim7nond 128 8 the the DT cord-282610-zim7nond 128 9 human human JJ cord-282610-zim7nond 128 10 microbiome microbiome NN cord-282610-zim7nond 128 11 and and CC cord-282610-zim7nond 128 12 further far RBR cord-282610-zim7nond 128 13 study study VB cord-282610-zim7nond 128 14 these these DT cord-282610-zim7nond 128 15 common common JJ cord-282610-zim7nond 128 16 mechanisms mechanism NNS cord-282610-zim7nond 128 17 of of IN cord-282610-zim7nond 128 18 survival survival NN cord-282610-zim7nond 128 19 and and CC cord-282610-zim7nond 128 20 persistence persistence NN cord-282610-zim7nond 128 21 . . . cord-282610-zim7nond 129 1 We -PRON- PRP cord-282610-zim7nond 129 2 must must MD cord-282610-zim7nond 129 3 examine examine VB cord-282610-zim7nond 129 4 microbe microbe NN cord-282610-zim7nond 129 5 and and CC cord-282610-zim7nond 129 6 viral viral JJ cord-282610-zim7nond 129 7 activity activity NN cord-282610-zim7nond 129 8 , , , cord-282610-zim7nond 129 9 microbe microbe NN cord-282610-zim7nond 129 10 and and CC cord-282610-zim7nond 129 11 viral viral JJ cord-282610-zim7nond 129 12 gene gene NN cord-282610-zim7nond 129 13 expression expression NN cord-282610-zim7nond 129 14 , , , cord-282610-zim7nond 129 15 and and CC cord-282610-zim7nond 129 16 the the DT cord-282610-zim7nond 129 17 myriad myriad JJ cord-282610-zim7nond 129 18 ways way NNS cord-282610-zim7nond 129 19 in in IN cord-282610-zim7nond 129 20 which which WDT cord-282610-zim7nond 129 21 the the DT cord-282610-zim7nond 129 22 proteins protein NNS cord-282610-zim7nond 129 23 and and CC cord-282610-zim7nond 129 24 metabolites metabolite NNS cord-282610-zim7nond 129 25 created create VBN cord-282610-zim7nond 129 26 by by IN cord-282610-zim7nond 129 27 these these DT cord-282610-zim7nond 129 28 organisms organism NNS cord-282610-zim7nond 129 29 interact interact VBP cord-282610-zim7nond 129 30 with with IN cord-282610-zim7nond 129 31 the the DT cord-282610-zim7nond 129 32 host host NN cord-282610-zim7nond 129 33 immune immune JJ cord-282610-zim7nond 129 34 system system NN cord-282610-zim7nond 129 35 , , , cord-282610-zim7nond 129 36 the the DT cord-282610-zim7nond 129 37 host host NN cord-282610-zim7nond 129 38 genome genome NN cord-282610-zim7nond 129 39 , , , cord-282610-zim7nond 129 40 and and CC cord-282610-zim7nond 129 41 each each DT cord-282610-zim7nond 129 42 other other JJ cord-282610-zim7nond 129 43 . . . cord-282610-zim7nond 130 1 The the DT cord-282610-zim7nond 130 2 genes gene NNS cord-282610-zim7nond 130 3 of of IN cord-282610-zim7nond 130 4 our -PRON- PRP$ cord-282610-zim7nond 130 5 microbial microbial JJ cord-282610-zim7nond 130 6 inhabitants inhabitant NNS cord-282610-zim7nond 130 7 greatly greatly RB cord-282610-zim7nond 130 8 outnumber outnumber VBP cord-282610-zim7nond 130 9 the the DT cord-282610-zim7nond 130 10 ∼20,500 ∼20,500 CD cord-282610-zim7nond 130 11 in in IN cord-282610-zim7nond 130 12 the the DT cord-282610-zim7nond 130 13 human human JJ cord-282610-zim7nond 130 14 genome genome NN cord-282610-zim7nond 130 15 . . . cord-282610-zim7nond 131 1 It -PRON- PRP cord-282610-zim7nond 131 2 follows follow VBZ cord-282610-zim7nond 131 3 that that IN cord-282610-zim7nond 131 4 the the DT cord-282610-zim7nond 131 5 majority majority NN cord-282610-zim7nond 131 6 of of IN cord-282610-zim7nond 131 7 metabolites metabolite NNS cord-282610-zim7nond 131 8 in in IN cord-282610-zim7nond 131 9 Homo homo NN cord-282610-zim7nond 131 10 sapiens sapien NNS cord-282610-zim7nond 131 11 are be VBP cord-282610-zim7nond 131 12 produced produce VBN cord-282610-zim7nond 131 13 or or CC cord-282610-zim7nond 131 14 modified modify VBN cord-282610-zim7nond 131 15 by by IN cord-282610-zim7nond 131 16 the the DT cord-282610-zim7nond 131 17 microbiome microbiome NN cord-282610-zim7nond 131 18 . . . cord-282610-zim7nond 132 1 Wikoff Wikoff NNP cord-282610-zim7nond 132 2 et et NNP cord-282610-zim7nond 132 3 al al NNP cord-282610-zim7nond 132 4 . . . cord-282610-zim7nond 133 1 ( ( -LRB- cord-282610-zim7nond 133 2 62 62 CD cord-282610-zim7nond 133 3 ) ) -RRB- cord-282610-zim7nond 133 4 found find VBD cord-282610-zim7nond 133 5 a a DT cord-282610-zim7nond 133 6 large large JJ cord-282610-zim7nond 133 7 effect effect NN cord-282610-zim7nond 133 8 of of IN cord-282610-zim7nond 133 9 the the DT cord-282610-zim7nond 133 10 gut gut NN cord-282610-zim7nond 133 11 microbiome microbiome NN cord-282610-zim7nond 133 12 on on IN cord-282610-zim7nond 133 13 murine murine JJ cord-282610-zim7nond 133 14 blood blood NN cord-282610-zim7nond 133 15 metabolites metabolite NNS cord-282610-zim7nond 133 16 including include VBG cord-282610-zim7nond 133 17 antioxidants antioxidant NNS cord-282610-zim7nond 133 18 , , , cord-282610-zim7nond 133 19 toxins toxin NNS cord-282610-zim7nond 133 20 and and CC cord-282610-zim7nond 133 21 amino amino JJ cord-282610-zim7nond 133 22 acids acid NNS cord-282610-zim7nond 133 23 . . . cord-282610-zim7nond 134 1 For for IN cord-282610-zim7nond 134 2 example example NN cord-282610-zim7nond 134 3 , , , cord-282610-zim7nond 134 4 production production NN cord-282610-zim7nond 134 5 of of IN cord-282610-zim7nond 134 6 the the DT cord-282610-zim7nond 134 7 metabolite metabolite JJ cord-282610-zim7nond 134 8 indole-3-propionic indole-3-propionic JJ cord-282610-zim7nond 134 9 acid acid NN cord-282610-zim7nond 134 10 was be VBD cord-282610-zim7nond 134 11 completely completely RB cord-282610-zim7nond 134 12 dependent dependent JJ cord-282610-zim7nond 134 13 on on IN cord-282610-zim7nond 134 14 the the DT cord-282610-zim7nond 134 15 presence presence NN cord-282610-zim7nond 134 16 of of IN cord-282610-zim7nond 134 17 gut gut NN cord-282610-zim7nond 134 18 microbes microbe NNS cord-282610-zim7nond 134 19 and and CC cord-282610-zim7nond 134 20 could could MD cord-282610-zim7nond 134 21 be be VB cord-282610-zim7nond 134 22 established establish VBN cord-282610-zim7nond 134 23 by by IN cord-282610-zim7nond 134 24 colonization colonization NN cord-282610-zim7nond 134 25 with with IN cord-282610-zim7nond 134 26 the the DT cord-282610-zim7nond 134 27 bacterium bacterium NN cord-282610-zim7nond 134 28 Clostridium clostridium NN cord-282610-zim7nond 134 29 sporogenes sporogene NNS cord-282610-zim7nond 134 30 . . . cord-282610-zim7nond 135 1 Many many JJ cord-282610-zim7nond 135 2 microbes microbe NNS cord-282610-zim7nond 135 3 , , , cord-282610-zim7nond 135 4 viruses virus NNS cord-282610-zim7nond 135 5 and and CC cord-282610-zim7nond 135 6 their -PRON- PRP$ cord-282610-zim7nond 135 7 corresponding correspond VBG cord-282610-zim7nond 135 8 proteins protein NNS cord-282610-zim7nond 135 9 / / SYM cord-282610-zim7nond 135 10 metabolites metabolite NNS cord-282610-zim7nond 135 11 directly directly RB cord-282610-zim7nond 135 12 modulate modulate VBP cord-282610-zim7nond 135 13 the the DT cord-282610-zim7nond 135 14 activity activity NN cord-282610-zim7nond 135 15 of of IN cord-282610-zim7nond 135 16 host host NN cord-282610-zim7nond 135 17 metabolic metabolic JJ cord-282610-zim7nond 135 18 , , , cord-282610-zim7nond 135 19 immune immune JJ cord-282610-zim7nond 135 20 , , , cord-282610-zim7nond 135 21 and and CC cord-282610-zim7nond 135 22 neurological neurological JJ cord-282610-zim7nond 135 23 pathways pathway NNS cord-282610-zim7nond 135 24 . . . cord-282610-zim7nond 136 1 In in IN cord-282610-zim7nond 136 2 other other JJ cord-282610-zim7nond 136 3 words word NNS cord-282610-zim7nond 136 4 , , , cord-282610-zim7nond 136 5 the the DT cord-282610-zim7nond 136 6 human human JJ cord-282610-zim7nond 136 7 holobiont holobiont NN cord-282610-zim7nond 136 8 is be VBZ cord-282610-zim7nond 136 9 controlled control VBN cord-282610-zim7nond 136 10 by by IN cord-282610-zim7nond 136 11 the the DT cord-282610-zim7nond 136 12 human human JJ cord-282610-zim7nond 136 13 genome genome NN cord-282610-zim7nond 136 14 , , , cord-282610-zim7nond 136 15 our -PRON- PRP$ cord-282610-zim7nond 136 16 microbial microbial JJ cord-282610-zim7nond 136 17 / / SYM cord-282610-zim7nond 136 18 viral viral JJ cord-282610-zim7nond 136 19 genomes genome NNS cord-282610-zim7nond 136 20 and and CC cord-282610-zim7nond 136 21 their -PRON- PRP$ cord-282610-zim7nond 136 22 respective respective JJ cord-282610-zim7nond 136 23 metabolites metabolite NNS cord-282610-zim7nond 136 24 working work VBG cord-282610-zim7nond 136 25 in in IN cord-282610-zim7nond 136 26 tandem tandem NN cord-282610-zim7nond 136 27 . . . cord-282610-zim7nond 137 1 A a DT cord-282610-zim7nond 137 2 growing grow VBG cord-282610-zim7nond 137 3 number number NN cord-282610-zim7nond 137 4 of of IN cord-282610-zim7nond 137 5 studies study NNS cord-282610-zim7nond 137 6 provide provide VBP cord-282610-zim7nond 137 7 examples example NNS cord-282610-zim7nond 137 8 of of IN cord-282610-zim7nond 137 9 this this DT cord-282610-zim7nond 137 10 metabolic metabolic JJ cord-282610-zim7nond 137 11 overlap overlap NN cord-282610-zim7nond 137 12 . . . cord-282610-zim7nond 138 1 While while IN cord-282610-zim7nond 138 2 many many JJ cord-282610-zim7nond 138 3 such such JJ cord-282610-zim7nond 138 4 studies study NNS cord-282610-zim7nond 138 5 have have VBP cord-282610-zim7nond 138 6 been be VBN cord-282610-zim7nond 138 7 conducted conduct VBN cord-282610-zim7nond 138 8 in in IN cord-282610-zim7nond 138 9 mice mouse NNS cord-282610-zim7nond 138 10 , , , cord-282610-zim7nond 138 11 their -PRON- PRP$ cord-282610-zim7nond 138 12 general general JJ cord-282610-zim7nond 138 13 trends trend NNS cord-282610-zim7nond 138 14 carry carry VBP cord-282610-zim7nond 138 15 over over RP cord-282610-zim7nond 138 16 to to IN cord-282610-zim7nond 138 17 humans human NNS cord-282610-zim7nond 138 18 . . . cord-282610-zim7nond 139 1 For for IN cord-282610-zim7nond 139 2 example example NN cord-282610-zim7nond 139 3 , , , cord-282610-zim7nond 139 4 ME ME NNP cord-282610-zim7nond 139 5 / / SYM cord-282610-zim7nond 139 6 CFS CFS NNP cord-282610-zim7nond 139 7 is be VBZ cord-282610-zim7nond 139 8 associated associate VBN cord-282610-zim7nond 139 9 with with IN cord-282610-zim7nond 139 10 natural natural JJ cord-282610-zim7nond 139 11 killer killer NN cord-282610-zim7nond 139 12 ( ( -LRB- cord-282610-zim7nond 139 13 NK NK NNP cord-282610-zim7nond 139 14 ) ) -RRB- cord-282610-zim7nond 139 15 cell cell NN cord-282610-zim7nond 139 16 abnormalities abnormality NNS cord-282610-zim7nond 139 17 , , , cord-282610-zim7nond 139 18 including include VBG cord-282610-zim7nond 139 19 reduced reduce VBN cord-282610-zim7nond 139 20 natural natural JJ cord-282610-zim7nond 139 21 killer killer NN cord-282610-zim7nond 139 22 cell cell NN cord-282610-zim7nond 139 23 activity activity NN cord-282610-zim7nond 139 24 ( ( -LRB- cord-282610-zim7nond 139 25 63 63 CD cord-282610-zim7nond 139 26 ) ) -RRB- cord-282610-zim7nond 139 27 . . . cord-282610-zim7nond 140 1 These these DT cord-282610-zim7nond 140 2 findings finding NNS cord-282610-zim7nond 140 3 must must MD cord-282610-zim7nond 140 4 be be VB cord-282610-zim7nond 140 5 interpreted interpret VBN cord-282610-zim7nond 140 6 to to TO cord-282610-zim7nond 140 7 account account VB cord-282610-zim7nond 140 8 for for IN cord-282610-zim7nond 140 9 the the DT cord-282610-zim7nond 140 10 fact fact NN cord-282610-zim7nond 140 11 that that IN cord-282610-zim7nond 140 12 NK NK NNP cord-282610-zim7nond 140 13 activity activity NN cord-282610-zim7nond 140 14 is be VBZ cord-282610-zim7nond 140 15 modulated modulate VBN cord-282610-zim7nond 140 16 by by IN cord-282610-zim7nond 140 17 the the DT cord-282610-zim7nond 140 18 bacterial bacterial JJ cord-282610-zim7nond 140 19 microbiome microbiome NN cord-282610-zim7nond 140 20 . . . cord-282610-zim7nond 141 1 One one CD cord-282610-zim7nond 141 2 study study NN cord-282610-zim7nond 141 3 found find VBD cord-282610-zim7nond 141 4 that that IN cord-282610-zim7nond 141 5 bile bile NN cord-282610-zim7nond 141 6 acids acid NNS cord-282610-zim7nond 141 7 modified modify VBN cord-282610-zim7nond 141 8 by by IN cord-282610-zim7nond 141 9 the the DT cord-282610-zim7nond 141 10 gut gut NN cord-282610-zim7nond 141 11 microbiome microbiome NN cord-282610-zim7nond 141 12 impacted impact VBD cord-282610-zim7nond 141 13 liver liver NN cord-282610-zim7nond 141 14 cell cell NN cord-282610-zim7nond 141 15 gene gene NN cord-282610-zim7nond 141 16 expression expression NN cord-282610-zim7nond 141 17 in in IN cord-282610-zim7nond 141 18 a a DT cord-282610-zim7nond 141 19 manner manner NN cord-282610-zim7nond 141 20 that that WDT cord-282610-zim7nond 141 21 controlled control VBN cord-282610-zim7nond 141 22 NK NK NNP cord-282610-zim7nond 141 23 cell cell NN cord-282610-zim7nond 141 24 accumulation accumulation NN cord-282610-zim7nond 141 25 and and CC cord-282610-zim7nond 141 26 anti anti JJ cord-282610-zim7nond 141 27 - - JJ cord-282610-zim7nond 141 28 tumor tumor JJ cord-282610-zim7nond 141 29 activity activity NN cord-282610-zim7nond 141 30 ( ( -LRB- cord-282610-zim7nond 141 31 64 64 CD cord-282610-zim7nond 141 32 ) ) -RRB- cord-282610-zim7nond 141 33 . . . cord-282610-zim7nond 142 1 Similarly similarly RB cord-282610-zim7nond 142 2 , , , cord-282610-zim7nond 142 3 a a DT cord-282610-zim7nond 142 4 mixture mixture NN cord-282610-zim7nond 142 5 of of IN cord-282610-zim7nond 142 6 lactic lactic JJ cord-282610-zim7nond 142 7 acid acid NN cord-282610-zim7nond 142 8 bacteria bacteria NNS cord-282610-zim7nond 142 9 from from IN cord-282610-zim7nond 142 10 kefir kefir NN cord-282610-zim7nond 142 11 increased increase VBD cord-282610-zim7nond 142 12 the the DT cord-282610-zim7nond 142 13 cytotoxicity cytotoxicity NN cord-282610-zim7nond 142 14 of of IN cord-282610-zim7nond 142 15 human human JJ cord-282610-zim7nond 142 16 NK NK NNP cord-282610-zim7nond 142 17 KHYG-1 KHYG-1 NNS cord-282610-zim7nond 142 18 cells cell NNS cord-282610-zim7nond 142 19 to to IN cord-282610-zim7nond 142 20 human human JJ cord-282610-zim7nond 142 21 chronic chronic NN cord-282610-zim7nond 142 22 leukemia leukemia NN cord-282610-zim7nond 142 23 cells cell NNS cord-282610-zim7nond 142 24 and and CC cord-282610-zim7nond 142 25 colorectal colorectal JJ cord-282610-zim7nond 142 26 tumor tumor NN cord-282610-zim7nond 142 27 cells cell NNS cord-282610-zim7nond 142 28 ( ( -LRB- cord-282610-zim7nond 142 29 65 65 CD cord-282610-zim7nond 142 30 ) ) -RRB- cord-282610-zim7nond 142 31 . . . cord-282610-zim7nond 143 1 The the DT cord-282610-zim7nond 143 2 microbiome microbiome NN cord-282610-zim7nond 143 3 and and CC cord-282610-zim7nond 143 4 its -PRON- PRP$ cord-282610-zim7nond 143 5 metabolites metabolite NNS cord-282610-zim7nond 143 6 also also RB cord-282610-zim7nond 143 7 impact impact VBP cord-282610-zim7nond 143 8 the the DT cord-282610-zim7nond 143 9 activity activity NN cord-282610-zim7nond 143 10 of of IN cord-282610-zim7nond 143 11 related related JJ cord-282610-zim7nond 143 12 immune immune JJ cord-282610-zim7nond 143 13 cells cell NNS cord-282610-zim7nond 143 14 . . . cord-282610-zim7nond 144 1 Rothhammer Rothhammer NNP cord-282610-zim7nond 144 2 et et FW cord-282610-zim7nond 144 3 al al NNP cord-282610-zim7nond 144 4 . . . cord-282610-zim7nond 145 1 ( ( -LRB- cord-282610-zim7nond 145 2 66 66 CD cord-282610-zim7nond 145 3 ) ) -RRB- cord-282610-zim7nond 145 4 found find VBD cord-282610-zim7nond 146 1 that that IN cord-282610-zim7nond 146 2 tryptophan tryptophan NN cord-282610-zim7nond 146 3 created create VBN cord-282610-zim7nond 146 4 by by IN cord-282610-zim7nond 146 5 the the DT cord-282610-zim7nond 146 6 gut gut NN cord-282610-zim7nond 146 7 microbiome microbiome NN cord-282610-zim7nond 146 8 interacted interact VBN cord-282610-zim7nond 146 9 with with IN cord-282610-zim7nond 146 10 the the DT cord-282610-zim7nond 146 11 AHR AHR NNP cord-282610-zim7nond 146 12 receptor receptor NN cord-282610-zim7nond 146 13 on on IN cord-282610-zim7nond 146 14 microglia microglia NNP cord-282610-zim7nond 146 15 / / SYM cord-282610-zim7nond 146 16 astrocytes astrocyte NNS cord-282610-zim7nond 146 17 . . . cord-282610-zim7nond 147 1 Subsequent subsequent JJ cord-282610-zim7nond 147 2 changes change NNS cord-282610-zim7nond 147 3 in in IN cord-282610-zim7nond 147 4 gene gene NN cord-282610-zim7nond 147 5 expression expression NN cord-282610-zim7nond 147 6 regulated regulate VBN cord-282610-zim7nond 147 7 communication communication NN cord-282610-zim7nond 147 8 between between IN cord-282610-zim7nond 147 9 the the DT cord-282610-zim7nond 147 10 two two CD cord-282610-zim7nond 147 11 cell cell NN cord-282610-zim7nond 147 12 types type NNS cord-282610-zim7nond 147 13 . . . cord-282610-zim7nond 148 1 Various various JJ cord-282610-zim7nond 148 2 forms form NNS cord-282610-zim7nond 148 3 of of IN cord-282610-zim7nond 148 4 autonomic autonomic JJ cord-282610-zim7nond 148 5 dysfunction dysfunction NN cord-282610-zim7nond 148 6 are be VBP cord-282610-zim7nond 148 7 also also RB cord-282610-zim7nond 148 8 common common JJ cord-282610-zim7nond 148 9 in in IN cord-282610-zim7nond 148 10 ME ME NNP cord-282610-zim7nond 148 11 / / SYM cord-282610-zim7nond 148 12 CFS CFS NNP cord-282610-zim7nond 148 13 ( ( -LRB- cord-282610-zim7nond 148 14 67 67 CD cord-282610-zim7nond 148 15 , , , cord-282610-zim7nond 148 16 68 68 CD cord-282610-zim7nond 148 17 ) ) -RRB- cord-282610-zim7nond 148 18 . . . cord-282610-zim7nond 149 1 It -PRON- PRP cord-282610-zim7nond 149 2 is be VBZ cord-282610-zim7nond 149 3 subsequently subsequently RB cord-282610-zim7nond 149 4 important important JJ cord-282610-zim7nond 149 5 to to TO cord-282610-zim7nond 149 6 consider consider VB cord-282610-zim7nond 149 7 that that IN cord-282610-zim7nond 149 8 the the DT cord-282610-zim7nond 149 9 microbiome microbiome NN cord-282610-zim7nond 149 10 may may MD cord-282610-zim7nond 149 11 contribute contribute VB cord-282610-zim7nond 149 12 to to TO cord-282610-zim7nond 149 13 host host VB cord-282610-zim7nond 149 14 blood blood NN cord-282610-zim7nond 149 15 pressure pressure NN cord-282610-zim7nond 149 16 regulation regulation NN cord-282610-zim7nond 149 17 . . . cord-282610-zim7nond 150 1 Pluznick Pluznick NNP cord-282610-zim7nond 150 2 et et NNP cord-282610-zim7nond 150 3 al al NNP cord-282610-zim7nond 150 4 . . . cord-282610-zim7nond 151 1 ( ( -LRB- cord-282610-zim7nond 151 2 69 69 CD cord-282610-zim7nond 151 3 ) ) -RRB- cord-282610-zim7nond 151 4 found find VBD cord-282610-zim7nond 151 5 that that IN cord-282610-zim7nond 151 6 gut gut NN cord-282610-zim7nond 151 7 microbiomederived microbiomederived NNP cord-282610-zim7nond 151 8 Short Short NNP cord-282610-zim7nond 151 9 Chain Chain NNP cord-282610-zim7nond 151 10 Fatty fatty JJ cord-282610-zim7nond 151 11 Acids acid NNS cord-282610-zim7nond 151 12 such such JJ cord-282610-zim7nond 151 13 as as IN cord-282610-zim7nond 151 14 acetate acetate NN cord-282610-zim7nond 151 15 and and CC cord-282610-zim7nond 151 16 propionate propionate NN cord-282610-zim7nond 151 17 travel travel NN cord-282610-zim7nond 151 18 to to IN cord-282610-zim7nond 151 19 the the DT cord-282610-zim7nond 151 20 kidneys kidney NNS cord-282610-zim7nond 151 21 and and CC cord-282610-zim7nond 151 22 blood blood NN cord-282610-zim7nond 151 23 vessels vessel NNS cord-282610-zim7nond 151 24 . . . cord-282610-zim7nond 152 1 There there RB cord-282610-zim7nond 152 2 they -PRON- PRP cord-282610-zim7nond 152 3 impacted impact VBD cord-282610-zim7nond 152 4 activity activity NN cord-282610-zim7nond 152 5 of of IN cord-282610-zim7nond 152 6 Olfr78 Olfr78 NNP cord-282610-zim7nond 152 7 and and CC cord-282610-zim7nond 152 8 Gpr41 Gpr41 NNP cord-282610-zim7nond 152 9 , , , cord-282610-zim7nond 152 10 two two CD cord-282610-zim7nond 152 11 host host NN cord-282610-zim7nond 152 12 receptors receptor NNS cord-282610-zim7nond 152 13 that that WDT cord-282610-zim7nond 152 14 control control VBP cord-282610-zim7nond 152 15 circulation circulation NN cord-282610-zim7nond 152 16 and and CC cord-282610-zim7nond 152 17 blood blood NN cord-282610-zim7nond 152 18 flow flow NN cord-282610-zim7nond 152 19 . . . cord-282610-zim7nond 153 1 Microbial microbial JJ cord-282610-zim7nond 153 2 modulation modulation NN cord-282610-zim7nond 153 3 of of IN cord-282610-zim7nond 153 4 host host NN cord-282610-zim7nond 153 5 pathways pathway NNS cord-282610-zim7nond 153 6 can can MD cord-282610-zim7nond 153 7 also also RB cord-282610-zim7nond 153 8 drive drive VB cord-282610-zim7nond 153 9 inflammatory inflammatory JJ cord-282610-zim7nond 153 10 disease disease NN cord-282610-zim7nond 153 11 processes process NNS cord-282610-zim7nond 153 12 . . . cord-282610-zim7nond 154 1 Pathogens pathogen NNS cord-282610-zim7nond 154 2 and and CC cord-282610-zim7nond 154 3 their -PRON- PRP$ cord-282610-zim7nond 154 4 associated associate VBN cord-282610-zim7nond 154 5 proteins protein NNS cord-282610-zim7nond 154 6 / / SYM cord-282610-zim7nond 154 7 metabolites metabolite NNS cord-282610-zim7nond 154 8 control control VBP cord-282610-zim7nond 154 9 human human JJ cord-282610-zim7nond 154 10 metabolism metabolism NN cord-282610-zim7nond 154 11 and and CC cord-282610-zim7nond 154 12 gene gene NN cord-282610-zim7nond 154 13 expression expression NN cord-282610-zim7nond 154 14 in in IN cord-282610-zim7nond 154 15 a a DT cord-282610-zim7nond 154 16 manner manner NN cord-282610-zim7nond 154 17 that that WDT cord-282610-zim7nond 154 18 can can MD cord-282610-zim7nond 154 19 push push VB cord-282610-zim7nond 154 20 the the DT cord-282610-zim7nond 154 21 holobiont holobiont NN cord-282610-zim7nond 154 22 toward toward IN cord-282610-zim7nond 154 23 a a DT cord-282610-zim7nond 154 24 state state NN cord-282610-zim7nond 154 25 of of IN cord-282610-zim7nond 154 26 imbalance imbalance NN cord-282610-zim7nond 154 27 and and CC cord-282610-zim7nond 154 28 illness illness NN cord-282610-zim7nond 154 29 . . . cord-282610-zim7nond 155 1 For for IN cord-282610-zim7nond 155 2 example example NN cord-282610-zim7nond 155 3 , , , cord-282610-zim7nond 155 4 Rizzo Rizzo NNP cord-282610-zim7nond 155 5 et et NNP cord-282610-zim7nond 155 6 al al NNP cord-282610-zim7nond 155 7 . . . cord-282610-zim7nond 156 1 ( ( -LRB- cord-282610-zim7nond 156 2 70 70 CD cord-282610-zim7nond 156 3 ) ) -RRB- cord-282610-zim7nond 156 4 found find VBD cord-282610-zim7nond 156 5 that that IN cord-282610-zim7nond 156 6 Human Human NNP cord-282610-zim7nond 156 7 Herpes Herpes NNP cord-282610-zim7nond 156 8 Viruses Viruses NNPS cord-282610-zim7nond 156 9 6A/6B 6a/6b CD cord-282610-zim7nond 156 10 infected infect VBN cord-282610-zim7nond 156 11 NK NK NNP cord-282610-zim7nond 156 12 cells cell NNS cord-282610-zim7nond 156 13 . . . cord-282610-zim7nond 157 1 This this DT cord-282610-zim7nond 157 2 infection infection NN cord-282610-zim7nond 157 3 significantly significantly RB cord-282610-zim7nond 157 4 modified modify VBD cord-282610-zim7nond 157 5 expression expression NN cord-282610-zim7nond 157 6 of of IN cord-282610-zim7nond 157 7 key key JJ cord-282610-zim7nond 157 8 host host NN cord-282610-zim7nond 157 9 miRNAs miRNAs NNP cord-282610-zim7nond 157 10 and and CC cord-282610-zim7nond 157 11 transcription transcription NN cord-282610-zim7nond 157 12 factors factor NNS cord-282610-zim7nond 157 13 . . . cord-282610-zim7nond 158 1 Mycobacterium Mycobacterium NNP cord-282610-zim7nond 158 2 leprae leprae NNP cord-282610-zim7nond 158 3 has have VBZ cord-282610-zim7nond 158 4 been be VBN cord-282610-zim7nond 158 5 shown show VBN cord-282610-zim7nond 158 6 to to TO cord-282610-zim7nond 158 7 alter alter VB cord-282610-zim7nond 158 8 human human JJ cord-282610-zim7nond 158 9 gene gene NN cord-282610-zim7nond 158 10 expression expression NN cord-282610-zim7nond 158 11 in in IN cord-282610-zim7nond 158 12 a a DT cord-282610-zim7nond 158 13 manner manner NN cord-282610-zim7nond 158 14 that that WDT cord-282610-zim7nond 158 15 allows allow VBZ cord-282610-zim7nond 158 16 it -PRON- PRP cord-282610-zim7nond 158 17 to to TO cord-282610-zim7nond 158 18 hijack hijack VB cord-282610-zim7nond 158 19 and and CC cord-282610-zim7nond 158 20 reprogram reprogram VB cord-282610-zim7nond 158 21 adult adult NN cord-282610-zim7nond 158 22 Schwann Schwann NNP cord-282610-zim7nond 158 23 cells cell NNS cord-282610-zim7nond 158 24 to to IN cord-282610-zim7nond 158 25 a a DT cord-282610-zim7nond 158 26 stem stem NN cord-282610-zim7nond 158 27 - - HYPH cord-282610-zim7nond 158 28 like like JJ cord-282610-zim7nond 158 29 state state NN cord-282610-zim7nond 158 30 ( ( -LRB- cord-282610-zim7nond 158 31 71 71 CD cord-282610-zim7nond 158 32 ) ) -RRB- cord-282610-zim7nond 158 33 . . . cord-282610-zim7nond 159 1 In in IN cord-282610-zim7nond 159 2 a a DT cord-282610-zim7nond 159 3 murine murine JJ cord-282610-zim7nond 159 4 model model NN cord-282610-zim7nond 159 5 of of IN cord-282610-zim7nond 159 6 diabetes diabetes NN cord-282610-zim7nond 159 7 , , , cord-282610-zim7nond 159 8 Liu Liu NNP cord-282610-zim7nond 159 9 et et NNP cord-282610-zim7nond 159 10 al al NNP cord-282610-zim7nond 159 11 . . . cord-282610-zim7nond 160 1 ( ( -LRB- cord-282610-zim7nond 160 2 72 72 CD cord-282610-zim7nond 160 3 ) ) -RRB- cord-282610-zim7nond 160 4 found find VBD cord-282610-zim7nond 160 5 that that IN cord-282610-zim7nond 160 6 eLtaS eltas NN cord-282610-zim7nond 160 7 , , , cord-282610-zim7nond 160 8 a a DT cord-282610-zim7nond 160 9 protein protein NN cord-282610-zim7nond 160 10 created create VBN cord-282610-zim7nond 160 11 by by IN cord-282610-zim7nond 160 12 S. S. NNP cord-282610-zim7nond 160 13 aureus aureus NN cord-282610-zim7nond 160 14 , , , cord-282610-zim7nond 160 15 prevented prevent VBD cord-282610-zim7nond 160 16 insulin insulin NN cord-282610-zim7nond 160 17 from from IN cord-282610-zim7nond 160 18 correctly correctly RB cord-282610-zim7nond 160 19 binding bind VBG cord-282610-zim7nond 160 20 its -PRON- PRP$ cord-282610-zim7nond 160 21 target target NN cord-282610-zim7nond 160 22 receptor receptor NN cord-282610-zim7nond 160 23 . . . cord-282610-zim7nond 161 1 This this DT cord-282610-zim7nond 161 2 inhibited inhibit VBD cord-282610-zim7nond 161 3 the the DT cord-282610-zim7nond 161 4 phosphorylation phosphorylation NN cord-282610-zim7nond 161 5 of of IN cord-282610-zim7nond 161 6 downstream downstream JJ cord-282610-zim7nond 161 7 signaling signal VBG cord-282610-zim7nond 161 8 proteins protein NNS cord-282610-zim7nond 161 9 and and CC cord-282610-zim7nond 161 10 caused cause VBD cord-282610-zim7nond 161 11 the the DT cord-282610-zim7nond 161 12 mice mouse NNS cord-282610-zim7nond 161 13 in in IN cord-282610-zim7nond 161 14 the the DT cord-282610-zim7nond 161 15 study study NN cord-282610-zim7nond 161 16 to to TO cord-282610-zim7nond 161 17 develop develop VB cord-282610-zim7nond 161 18 impaired impaired JJ cord-282610-zim7nond 161 19 glucose glucose NN cord-282610-zim7nond 161 20 tolerance tolerance NN cord-282610-zim7nond 161 21 . . . cord-282610-zim7nond 162 1 The the DT cord-282610-zim7nond 162 2 ability ability NN cord-282610-zim7nond 162 3 of of IN cord-282610-zim7nond 162 4 pathogens pathogen NNS cord-282610-zim7nond 162 5 to to TO cord-282610-zim7nond 162 6 interfere interfere VB cord-282610-zim7nond 162 7 with with IN cord-282610-zim7nond 162 8 host host NN cord-282610-zim7nond 162 9 metabolism metabolism NN cord-282610-zim7nond 162 10 is be VBZ cord-282610-zim7nond 162 11 tied tie VBN cord-282610-zim7nond 162 12 to to IN cord-282610-zim7nond 162 13 the the DT cord-282610-zim7nond 162 14 dynamics dynamic NNS cord-282610-zim7nond 162 15 of of IN cord-282610-zim7nond 162 16 the the DT cord-282610-zim7nond 162 17 communities community NNS cord-282610-zim7nond 162 18 in in IN cord-282610-zim7nond 162 19 which which WDT cord-282610-zim7nond 162 20 they -PRON- PRP cord-282610-zim7nond 162 21 persist persist VBP cord-282610-zim7nond 162 22 . . . cord-282610-zim7nond 163 1 Like like IN cord-282610-zim7nond 163 2 organisms organism NNS cord-282610-zim7nond 163 3 in in IN cord-282610-zim7nond 163 4 any any DT cord-282610-zim7nond 163 5 ecosystem ecosystem NN cord-282610-zim7nond 163 6 , , , cord-282610-zim7nond 163 7 human human JJ cord-282610-zim7nond 163 8 microbes microbe NNS cord-282610-zim7nond 163 9 constantly constantly RB cord-282610-zim7nond 163 10 interact interact VBP cord-282610-zim7nond 163 11 , , , cord-282610-zim7nond 163 12 both both CC cord-282610-zim7nond 163 13 directly directly RB cord-282610-zim7nond 163 14 and and CC cord-282610-zim7nond 163 15 indirectly indirectly RB cord-282610-zim7nond 163 16 . . . cord-282610-zim7nond 164 1 The the DT cord-282610-zim7nond 164 2 proteins protein NNS cord-282610-zim7nond 164 3 and and CC cord-282610-zim7nond 164 4 metabolites metabolite NNS cord-282610-zim7nond 164 5 they -PRON- PRP cord-282610-zim7nond 164 6 create create VBP cord-282610-zim7nond 164 7 are be VBP cord-282610-zim7nond 164 8 also also RB cord-282610-zim7nond 164 9 in in IN cord-282610-zim7nond 164 10 continual continual JJ cord-282610-zim7nond 164 11 interplay interplay NN cord-282610-zim7nond 164 12 . . . cord-282610-zim7nond 165 1 Communities community NNS cord-282610-zim7nond 165 2 of of IN cord-282610-zim7nond 165 3 microbes microbe NNS cord-282610-zim7nond 165 4 often often RB cord-282610-zim7nond 165 5 exhibit exhibit VBP cord-282610-zim7nond 165 6 synergistic synergistic JJ cord-282610-zim7nond 165 7 interactions interaction NNS cord-282610-zim7nond 165 8 for for IN cord-282610-zim7nond 165 9 improved improved JJ cord-282610-zim7nond 165 10 nutrient nutrient NN cord-282610-zim7nond 165 11 acquisition acquisition NN cord-282610-zim7nond 165 12 , , , cord-282610-zim7nond 165 13 protection protection NN cord-282610-zim7nond 165 14 from from IN cord-282610-zim7nond 165 15 host host NN cord-282610-zim7nond 165 16 defenses defense NNS cord-282610-zim7nond 165 17 , , , cord-282610-zim7nond 165 18 and and CC cord-282610-zim7nond 165 19 survival survival NN cord-282610-zim7nond 165 20 in in IN cord-282610-zim7nond 165 21 an an DT cord-282610-zim7nond 165 22 inflammatory inflammatory JJ cord-282610-zim7nond 165 23 environment environment NN cord-282610-zim7nond 165 24 ( ( -LRB- cord-282610-zim7nond 165 25 73 73 CD cord-282610-zim7nond 165 26 ) ) -RRB- cord-282610-zim7nond 165 27 . . . cord-282610-zim7nond 166 1 These these DT cord-282610-zim7nond 166 2 include include VBP cord-282610-zim7nond 166 3 biofilm biofilm NN cord-282610-zim7nond 166 4 formation formation NN cord-282610-zim7nond 166 5 and and CC cord-282610-zim7nond 166 6 cooperative cooperative JJ cord-282610-zim7nond 166 7 signaling signaling NN cord-282610-zim7nond 166 8 via via IN cord-282610-zim7nond 166 9 quorum quorum NN cord-282610-zim7nond 166 10 sensing sensing NN cord-282610-zim7nond 166 11 peptides peptide NNS cord-282610-zim7nond 166 12 . . . cord-282610-zim7nond 167 1 Humphries Humphries NNP cord-282610-zim7nond 167 2 et et NNP cord-282610-zim7nond 167 3 al al NNP cord-282610-zim7nond 167 4 . . . cord-282610-zim7nond 168 1 ( ( -LRB- cord-282610-zim7nond 168 2 74 74 CD cord-282610-zim7nond 168 3 ) ) -RRB- cord-282610-zim7nond 168 4 recently recently RB cord-282610-zim7nond 168 5 reported report VBD cord-282610-zim7nond 168 6 that that IN cord-282610-zim7nond 168 7 biofilm biofilm NN cord-282610-zim7nond 168 8 bacteria bacteria NNS cord-282610-zim7nond 168 9 can can MD cord-282610-zim7nond 168 10 additionally additionally RB cord-282610-zim7nond 168 11 communicate communicate VB cord-282610-zim7nond 168 12 via via IN cord-282610-zim7nond 168 13 ion ion NN cord-282610-zim7nond 168 14 channel channel NN cord-282610-zim7nond 168 15 - - HYPH cord-282610-zim7nond 168 16 mediated mediate VBN cord-282610-zim7nond 168 17 electrical electrical JJ cord-282610-zim7nond 168 18 signaling signaling NN cord-282610-zim7nond 168 19 . . . cord-282610-zim7nond 169 1 Even even RB cord-282610-zim7nond 169 2 viruses virus NNS cord-282610-zim7nond 169 3 seldom seldom RB cord-282610-zim7nond 169 4 act act VBP cord-282610-zim7nond 169 5 as as IN cord-282610-zim7nond 169 6 single single JJ cord-282610-zim7nond 169 7 entities entity NNS cord-282610-zim7nond 169 8 . . . cord-282610-zim7nond 170 1 Diversity diversity NN cord-282610-zim7nond 170 2 and and CC cord-282610-zim7nond 170 3 equilibrium equilibrium NN cord-282610-zim7nond 170 4 of of IN cord-282610-zim7nond 170 5 the the DT cord-282610-zim7nond 170 6 bacterial bacterial JJ cord-282610-zim7nond 170 7 microbiome microbiome NN cord-282610-zim7nond 170 8 is be VBZ cord-282610-zim7nond 170 9 regulated regulate VBN cord-282610-zim7nond 170 10 by by IN cord-282610-zim7nond 170 11 bacteriophage bacteriophage NN cord-282610-zim7nond 170 12 predator predator NN cord-282610-zim7nond 170 13 - - HYPH cord-282610-zim7nond 170 14 prey prey NN cord-282610-zim7nond 170 15 dynamics dynamic NNS cord-282610-zim7nond 170 16 ( ( -LRB- cord-282610-zim7nond 170 17 75 75 CD cord-282610-zim7nond 170 18 ) ) -RRB- cord-282610-zim7nond 170 19 . . . cord-282610-zim7nond 171 1 Pfeiffer Pfeiffer NNP cord-282610-zim7nond 171 2 and and CC cord-282610-zim7nond 171 3 Virgin Virgin NNP cord-282610-zim7nond 171 4 ( ( -LRB- cord-282610-zim7nond 171 5 27 27 CD cord-282610-zim7nond 171 6 ) ) -RRB- cord-282610-zim7nond 171 7 found find VBD cord-282610-zim7nond 171 8 that that IN cord-282610-zim7nond 171 9 enteric enteric JJ cord-282610-zim7nond 171 10 viral viral JJ cord-282610-zim7nond 171 11 virulence virulence NN cord-282610-zim7nond 171 12 is be VBZ cord-282610-zim7nond 171 13 regulated regulate VBN cord-282610-zim7nond 171 14 by by IN cord-282610-zim7nond 171 15 the the DT cord-282610-zim7nond 171 16 activity activity NN cord-282610-zim7nond 171 17 of of IN cord-282610-zim7nond 171 18 neighboring neighbor VBG cord-282610-zim7nond 171 19 bacteria bacteria NNS cord-282610-zim7nond 171 20 , , , cord-282610-zim7nond 171 21 fungi fungus NNS cord-282610-zim7nond 171 22 , , , cord-282610-zim7nond 171 23 and and CC cord-282610-zim7nond 171 24 even even RB cord-282610-zim7nond 171 25 helminths helminth NNS cord-282610-zim7nond 171 26 . . . cord-282610-zim7nond 172 1 These these DT cord-282610-zim7nond 172 2 processes process NNS cord-282610-zim7nond 172 3 are be VBP cord-282610-zim7nond 172 4 called call VBN cord-282610-zim7nond 172 5 " " `` cord-282610-zim7nond 172 6 transkingdom transkingdom NN cord-282610-zim7nond 172 7 interactions interaction NNS cord-282610-zim7nond 172 8 . . . cord-282610-zim7nond 173 1 " " `` cord-282610-zim7nond 173 2 For for IN cord-282610-zim7nond 173 3 example example NN cord-282610-zim7nond 173 4 , , , cord-282610-zim7nond 173 5 human human JJ cord-282610-zim7nond 173 6 norovirus norovirus NN cord-282610-zim7nond 173 7 can can MD cord-282610-zim7nond 173 8 bind bind VB cord-282610-zim7nond 173 9 carbohydrate carbohydrate NN cord-282610-zim7nond 173 10 histo histo JJ cord-282610-zim7nond 173 11 - - HYPH cord-282610-zim7nond 173 12 blood blood NN cord-282610-zim7nond 173 13 group group NN cord-282610-zim7nond 173 14 antigens antigen NNS cord-282610-zim7nond 173 15 present present JJ cord-282610-zim7nond 173 16 on on IN cord-282610-zim7nond 173 17 certain certain JJ cord-282610-zim7nond 173 18 bacterial bacterial JJ cord-282610-zim7nond 173 19 cells cell NNS cord-282610-zim7nond 173 20 . . . cord-282610-zim7nond 174 1 This this DT cord-282610-zim7nond 174 2 facilitates facilitate VBZ cord-282610-zim7nond 174 3 the the DT cord-282610-zim7nond 174 4 ability ability NN cord-282610-zim7nond 174 5 of of IN cord-282610-zim7nond 174 6 norovirus norovirus NN cord-282610-zim7nond 174 7 to to TO cord-282610-zim7nond 174 8 infect infect VB cord-282610-zim7nond 174 9 human human JJ cord-282610-zim7nond 174 10 B b NN cord-282610-zim7nond 174 11 cells cell NNS cord-282610-zim7nond 174 12 ( ( -LRB- cord-282610-zim7nond 174 13 76 76 CD cord-282610-zim7nond 174 14 ) ) -RRB- cord-282610-zim7nond 174 15 . . . cord-282610-zim7nond 175 1 Interacting interact VBG cord-282610-zim7nond 175 2 microbes microbe NNS cord-282610-zim7nond 175 3 may may MD cord-282610-zim7nond 175 4 contribute contribute VB cord-282610-zim7nond 175 5 to to IN cord-282610-zim7nond 175 6 dysbiosis dysbiosis NN cord-282610-zim7nond 175 7 or or CC cord-282610-zim7nond 175 8 imbalance imbalance NN cord-282610-zim7nond 175 9 of of IN cord-282610-zim7nond 175 10 microbiome microbiome NN cord-282610-zim7nond 175 11 communities community NNS cord-282610-zim7nond 175 12 ( ( -LRB- cord-282610-zim7nond 175 13 77 77 CD cord-282610-zim7nond 175 14 ) ) -RRB- cord-282610-zim7nond 175 15 . . . cord-282610-zim7nond 176 1 This this DT cord-282610-zim7nond 176 2 dysbiosis dysbiosis NN cord-282610-zim7nond 176 3 is be VBZ cord-282610-zim7nond 176 4 characterized characterize VBN cord-282610-zim7nond 176 5 by by IN cord-282610-zim7nond 176 6 substantial substantial JJ cord-282610-zim7nond 176 7 shifts shift NNS cord-282610-zim7nond 176 8 in in IN cord-282610-zim7nond 176 9 community community NN cord-282610-zim7nond 176 10 structure structure NN cord-282610-zim7nond 176 11 and and CC cord-282610-zim7nond 176 12 diversity diversity NN cord-282610-zim7nond 176 13 . . . cord-282610-zim7nond 177 1 In in IN cord-282610-zim7nond 177 2 many many JJ cord-282610-zim7nond 177 3 cases case NNS cord-282610-zim7nond 177 4 , , , cord-282610-zim7nond 177 5 pathogens pathogen NNS cord-282610-zim7nond 177 6 proliferate proliferate VBP cord-282610-zim7nond 177 7 to to TO cord-282610-zim7nond 177 8 inhabit inhabit VB cord-282610-zim7nond 177 9 niches niche NNS cord-282610-zim7nond 177 10 once once RB cord-282610-zim7nond 177 11 occupied occupy VBN cord-282610-zim7nond 177 12 by by IN cord-282610-zim7nond 177 13 more more JJR cord-282610-zim7nond 177 14 innocuous innocuous JJ cord-282610-zim7nond 177 15 microbes microbe NNS cord-282610-zim7nond 177 16 . . . cord-282610-zim7nond 178 1 Most most RBS cord-282610-zim7nond 178 2 well well RB cord-282610-zim7nond 178 3 - - HYPH cord-282610-zim7nond 178 4 studied study VBN cord-282610-zim7nond 178 5 inflammatory inflammatory JJ cord-282610-zim7nond 178 6 disease disease NN cord-282610-zim7nond 178 7 states state NNS cord-282610-zim7nond 178 8 are be VBP cord-282610-zim7nond 178 9 tied tie VBN cord-282610-zim7nond 178 10 to to IN cord-282610-zim7nond 178 11 some some DT cord-282610-zim7nond 178 12 form form NN cord-282610-zim7nond 178 13 of of IN cord-282610-zim7nond 178 14 microbiome microbiome NN cord-282610-zim7nond 178 15 dysbiosis dysbiosis NN cord-282610-zim7nond 178 16 . . . cord-282610-zim7nond 179 1 These these DT cord-282610-zim7nond 179 2 include include VBP cord-282610-zim7nond 179 3 psoriatic psoriatic JJ cord-282610-zim7nond 179 4 arthritis arthritis NN cord-282610-zim7nond 179 5 , , , cord-282610-zim7nond 179 6 systemic systemic JJ cord-282610-zim7nond 179 7 lupus lupus NN cord-282610-zim7nond 179 8 erythematosus erythematosus NN cord-282610-zim7nond 179 9 , , , cord-282610-zim7nond 179 10 type type NN cord-282610-zim7nond 179 11 1 1 CD cord-282610-zim7nond 179 12 and and CC cord-282610-zim7nond 179 13 2 2 CD cord-282610-zim7nond 179 14 diabetes diabete NNS cord-282610-zim7nond 179 15 , , , cord-282610-zim7nond 179 16 Parkinson Parkinson NNP cord-282610-zim7nond 179 17 's 's POS cord-282610-zim7nond 179 18 disease disease NN cord-282610-zim7nond 179 19 and and CC cord-282610-zim7nond 179 20 a a DT cord-282610-zim7nond 179 21 growing grow VBG cord-282610-zim7nond 179 22 number number NN cord-282610-zim7nond 179 23 of of IN cord-282610-zim7nond 179 24 cancers cancer NNS cord-282610-zim7nond 179 25 ( ( -LRB- cord-282610-zim7nond 179 26 34 34 CD cord-282610-zim7nond 179 27 , , , cord-282610-zim7nond 179 28 78 78 CD cord-282610-zim7nond 179 29 , , , cord-282610-zim7nond 179 30 79 79 CD cord-282610-zim7nond 179 31 ) ) -RRB- cord-282610-zim7nond 179 32 . . . cord-282610-zim7nond 180 1 The the DT cord-282610-zim7nond 180 2 gut gut NN cord-282610-zim7nond 180 3 microbiome microbiome NN cord-282610-zim7nond 180 4 can can MD cord-282610-zim7nond 180 5 initiate initiate VB cord-282610-zim7nond 180 6 and and CC cord-282610-zim7nond 180 7 promote promote VB cord-282610-zim7nond 180 8 colorectal colorectal JJ cord-282610-zim7nond 180 9 cancer cancer NN cord-282610-zim7nond 180 10 at at IN cord-282610-zim7nond 180 11 all all DT cord-282610-zim7nond 180 12 stages stage NNS cord-282610-zim7nond 180 13 of of IN cord-282610-zim7nond 180 14 tumorigenesis tumorigenesis NN cord-282610-zim7nond 180 15 by by IN cord-282610-zim7nond 180 16 acting act VBG cord-282610-zim7nond 180 17 as as IN cord-282610-zim7nond 180 18 an an DT cord-282610-zim7nond 180 19 inducer inducer NN cord-282610-zim7nond 180 20 of of IN cord-282610-zim7nond 180 21 DNA dna NN cord-282610-zim7nond 180 22 damage damage NN cord-282610-zim7nond 180 23 , , , cord-282610-zim7nond 180 24 generating generate VBG cord-282610-zim7nond 180 25 epigenetic epigenetic JJ cord-282610-zim7nond 180 26 changes change NNS cord-282610-zim7nond 180 27 , , , cord-282610-zim7nond 180 28 regulating regulate VBG cord-282610-zim7nond 180 29 cell cell NN cord-282610-zim7nond 180 30 growth growth NN cord-282610-zim7nond 180 31 , , , cord-282610-zim7nond 180 32 and and CC cord-282610-zim7nond 180 33 modulating modulate VBG cord-282610-zim7nond 180 34 host host NN cord-282610-zim7nond 180 35 immune immune JJ cord-282610-zim7nond 180 36 responses response NNS cord-282610-zim7nond 180 37 ( ( -LRB- cord-282610-zim7nond 180 38 80 80 CD cord-282610-zim7nond 180 39 ) ) -RRB- cord-282610-zim7nond 180 40 . . . cord-282610-zim7nond 181 1 The the DT cord-282610-zim7nond 181 2 breast breast NN cord-282610-zim7nond 181 3 tissue tissue NN cord-282610-zim7nond 181 4 microbiome microbiome NN cord-282610-zim7nond 181 5 of of IN cord-282610-zim7nond 181 6 women woman NNS cord-282610-zim7nond 181 7 with with IN cord-282610-zim7nond 181 8 breast breast NN cord-282610-zim7nond 181 9 cancer cancer NN cord-282610-zim7nond 181 10 has have VBZ cord-282610-zim7nond 181 11 been be VBN cord-282610-zim7nond 181 12 shown show VBN cord-282610-zim7nond 181 13 to to TO cord-282610-zim7nond 181 14 differ differ VB cord-282610-zim7nond 181 15 substantially substantially RB cord-282610-zim7nond 181 16 in in IN cord-282610-zim7nond 181 17 composition composition NN cord-282610-zim7nond 181 18 , , , cord-282610-zim7nond 181 19 virulence virulence NN cord-282610-zim7nond 181 20 and and CC cord-282610-zim7nond 181 21 diversity diversity NN cord-282610-zim7nond 181 22 from from IN cord-282610-zim7nond 181 23 that that DT cord-282610-zim7nond 181 24 of of IN cord-282610-zim7nond 181 25 healthy healthy JJ cord-282610-zim7nond 181 26 controls control NNS cord-282610-zim7nond 181 27 ( ( -LRB- cord-282610-zim7nond 181 28 81 81 CD cord-282610-zim7nond 181 29 ) ) -RRB- cord-282610-zim7nond 181 30 . . . cord-282610-zim7nond 182 1 Species species NN cord-282610-zim7nond 182 2 composition composition NN cord-282610-zim7nond 182 3 of of IN cord-282610-zim7nond 182 4 the the DT cord-282610-zim7nond 182 5 bronchoalveolar bronchoalveolar NNP cord-282610-zim7nond 182 6 microbiome microbiome NN cord-282610-zim7nond 182 7 shifted shift VBD cord-282610-zim7nond 182 8 toward toward IN cord-282610-zim7nond 182 9 a a DT cord-282610-zim7nond 182 10 more more RBR cord-282610-zim7nond 182 11 pathogenic pathogenic JJ cord-282610-zim7nond 182 12 state state NN cord-282610-zim7nond 182 13 in in IN cord-282610-zim7nond 182 14 patients patient NNS cord-282610-zim7nond 182 15 with with IN cord-282610-zim7nond 182 16 sarcoidosis sarcoidosi NNS cord-282610-zim7nond 182 17 ( ( -LRB- cord-282610-zim7nond 182 18 82 82 CD cord-282610-zim7nond 182 19 ) ) -RRB- cord-282610-zim7nond 182 20 . . . cord-282610-zim7nond 183 1 Alterations alteration NNS cord-282610-zim7nond 183 2 in in IN cord-282610-zim7nond 183 3 the the DT cord-282610-zim7nond 183 4 enteric enteric JJ cord-282610-zim7nond 183 5 virome virome NN cord-282610-zim7nond 183 6 were be VBD cord-282610-zim7nond 183 7 reported report VBN cord-282610-zim7nond 183 8 prior prior RB cord-282610-zim7nond 183 9 to to IN cord-282610-zim7nond 183 10 disease disease NN cord-282610-zim7nond 183 11 onset onset NN cord-282610-zim7nond 183 12 in in IN cord-282610-zim7nond 183 13 children child NNS cord-282610-zim7nond 183 14 susceptible susceptible JJ cord-282610-zim7nond 183 15 to to IN cord-282610-zim7nond 183 16 developing develop VBG cord-282610-zim7nond 183 17 type type NN cord-282610-zim7nond 183 18 1 1 CD cord-282610-zim7nond 183 19 diabetes diabetes NN cord-282610-zim7nond 183 20 ( ( -LRB- cord-282610-zim7nond 183 21 83 83 CD cord-282610-zim7nond 183 22 ) ) -RRB- cord-282610-zim7nond 183 23 . . . cord-282610-zim7nond 184 1 Several several JJ cord-282610-zim7nond 184 2 research research NN cord-282610-zim7nond 184 3 teams team NNS cord-282610-zim7nond 184 4 have have VBP cord-282610-zim7nond 184 5 tied tie VBN cord-282610-zim7nond 184 6 ME ME NNP cord-282610-zim7nond 184 7 / / SYM cord-282610-zim7nond 184 8 CFS cfs NN cord-282610-zim7nond 184 9 to to IN cord-282610-zim7nond 184 10 bacterial bacterial JJ cord-282610-zim7nond 184 11 gut gut NN cord-282610-zim7nond 184 12 microbiome microbiome NN cord-282610-zim7nond 184 13 dysbiosis dysbiosis NN cord-282610-zim7nond 184 14 . . . cord-282610-zim7nond 185 1 Giloteaux Giloteaux NNP cord-282610-zim7nond 185 2 et et FW cord-282610-zim7nond 185 3 al al NNP cord-282610-zim7nond 185 4 . . . cord-282610-zim7nond 186 1 ( ( -LRB- cord-282610-zim7nond 186 2 21 21 CD cord-282610-zim7nond 186 3 ) ) -RRB- cord-282610-zim7nond 186 4 found find VBD cord-282610-zim7nond 186 5 that that IN cord-282610-zim7nond 186 6 gut gut NN cord-282610-zim7nond 186 7 microbiome microbiome NN cord-282610-zim7nond 186 8 bacterial bacterial JJ cord-282610-zim7nond 186 9 diversity diversity NN cord-282610-zim7nond 186 10 was be VBD cord-282610-zim7nond 186 11 decreased decrease VBN cord-282610-zim7nond 186 12 in in IN cord-282610-zim7nond 186 13 ME ME NNP cord-282610-zim7nond 186 14 / / SYM cord-282610-zim7nond 186 15 CFS CFS NNP cord-282610-zim7nond 186 16 subjects subject NNS cord-282610-zim7nond 186 17 compared compare VBN cord-282610-zim7nond 186 18 to to IN cord-282610-zim7nond 186 19 heathy heathy JJ cord-282610-zim7nond 186 20 controls control NNS cord-282610-zim7nond 186 21 . . . cord-282610-zim7nond 187 1 The the DT cord-282610-zim7nond 187 2 team team NN cord-282610-zim7nond 187 3 also also RB cord-282610-zim7nond 187 4 noted note VBD cord-282610-zim7nond 187 5 increases increase NNS cord-282610-zim7nond 187 6 in in IN cord-282610-zim7nond 187 7 certain certain JJ cord-282610-zim7nond 187 8 bacterial bacterial JJ cord-282610-zim7nond 187 9 species specie NNS cord-282610-zim7nond 187 10 associated associate VBN cord-282610-zim7nond 187 11 with with IN cord-282610-zim7nond 187 12 either either DT cord-282610-zim7nond 187 13 pro pro JJ cord-282610-zim7nond 187 14 - - JJ cord-282610-zim7nond 187 15 inflammatory inflammatory JJ cord-282610-zim7nond 187 16 or or CC cord-282610-zim7nond 187 17 anti anti JJ cord-282610-zim7nond 187 18 - - JJ cord-282610-zim7nond 187 19 inflammatory inflammatory JJ cord-282610-zim7nond 187 20 activity activity NN cord-282610-zim7nond 187 21 . . . cord-282610-zim7nond 188 1 Nagy Nagy NNP cord-282610-zim7nond 188 2 - - HYPH cord-282610-zim7nond 188 3 Szakal Szakal NNP cord-282610-zim7nond 188 4 et et FW cord-282610-zim7nond 188 5 al al NNP cord-282610-zim7nond 188 6 . . . cord-282610-zim7nond 189 1 ( ( -LRB- cord-282610-zim7nond 189 2 84 84 CD cord-282610-zim7nond 189 3 ) ) -RRB- cord-282610-zim7nond 189 4 also also RB cord-282610-zim7nond 189 5 analyzed analyze VBD cord-282610-zim7nond 189 6 the the DT cord-282610-zim7nond 189 7 ME ME NNP cord-282610-zim7nond 189 8 / / SYM cord-282610-zim7nond 189 9 CFS cfs NN cord-282610-zim7nond 189 10 gut gut NN cord-282610-zim7nond 189 11 microbiome microbiome NN cord-282610-zim7nond 189 12 . . . cord-282610-zim7nond 190 1 The the DT cord-282610-zim7nond 190 2 study study NN cord-282610-zim7nond 190 3 detected detect VBD cord-282610-zim7nond 190 4 seven seven CD cord-282610-zim7nond 190 5 gut gut NN cord-282610-zim7nond 190 6 bacterial bacterial JJ cord-282610-zim7nond 190 7 species specie NNS cord-282610-zim7nond 190 8 whose whose WP$ cord-282610-zim7nond 190 9 relative relative JJ cord-282610-zim7nond 190 10 abundance abundance NN cord-282610-zim7nond 190 11 differed differ VBD cord-282610-zim7nond 190 12 from from IN cord-282610-zim7nond 190 13 that that DT cord-282610-zim7nond 190 14 of of IN cord-282610-zim7nond 190 15 control control NN cord-282610-zim7nond 190 16 subjects subject NNS cord-282610-zim7nond 190 17 and and CC cord-282610-zim7nond 190 18 were be VBD cord-282610-zim7nond 190 19 strongly strongly RB cord-282610-zim7nond 190 20 associated associate VBN cord-282610-zim7nond 190 21 with with IN cord-282610-zim7nond 190 22 ME ME NNP cord-282610-zim7nond 190 23 / / SYM cord-282610-zim7nond 190 24 CFS CFS NNP cord-282610-zim7nond 190 25 . . . cord-282610-zim7nond 191 1 While while IN cord-282610-zim7nond 191 2 these these DT cord-282610-zim7nond 191 3 findings finding NNS cord-282610-zim7nond 191 4 are be VBP cord-282610-zim7nond 191 5 of of IN cord-282610-zim7nond 191 6 interest interest NN cord-282610-zim7nond 191 7 , , , cord-282610-zim7nond 191 8 gut gut NN cord-282610-zim7nond 191 9 microbiome microbiome NN cord-282610-zim7nond 191 10 composition composition NN cord-282610-zim7nond 191 11 is be VBZ cord-282610-zim7nond 191 12 additionally additionally RB cord-282610-zim7nond 191 13 impacted impact VBN cord-282610-zim7nond 191 14 by by IN cord-282610-zim7nond 191 15 a a DT cord-282610-zim7nond 191 16 host host NN cord-282610-zim7nond 191 17 of of IN cord-282610-zim7nond 191 18 environmental environmental JJ cord-282610-zim7nond 191 19 variables variable NNS cord-282610-zim7nond 191 20 that that WDT cord-282610-zim7nond 191 21 cause cause VBP cord-282610-zim7nond 191 22 large large JJ cord-282610-zim7nond 191 23 shifts shift NNS cord-282610-zim7nond 191 24 in in IN cord-282610-zim7nond 191 25 the the DT cord-282610-zim7nond 191 26 region region NN cord-282610-zim7nond 191 27 's 's POS cord-282610-zim7nond 191 28 microbial microbial JJ cord-282610-zim7nond 191 29 ecosystems ecosystem NNS cord-282610-zim7nond 191 30 . . . cord-282610-zim7nond 192 1 These these DT cord-282610-zim7nond 192 2 include include VBP cord-282610-zim7nond 192 3 geographic geographic JJ cord-282610-zim7nond 192 4 location location NN cord-282610-zim7nond 192 5 , , , cord-282610-zim7nond 192 6 food food NN cord-282610-zim7nond 192 7 consumption consumption NN cord-282610-zim7nond 192 8 , , , cord-282610-zim7nond 192 9 and and CC cord-282610-zim7nond 192 10 even even RB cord-282610-zim7nond 192 11 time time NN cord-282610-zim7nond 192 12 of of IN cord-282610-zim7nond 192 13 day day NN cord-282610-zim7nond 192 14 ( ( -LRB- cord-282610-zim7nond 192 15 85 85 CD cord-282610-zim7nond 192 16 ) ) -RRB- cord-282610-zim7nond 192 17 . . . cord-282610-zim7nond 193 1 Many many JJ cord-282610-zim7nond 193 2 research research NN cord-282610-zim7nond 193 3 teams team NNS cord-282610-zim7nond 193 4 studying study VBG cord-282610-zim7nond 193 5 inflammatory inflammatory JJ cord-282610-zim7nond 193 6 conditions condition NNS cord-282610-zim7nond 193 7 have have VBP cord-282610-zim7nond 193 8 struggled struggle VBN cord-282610-zim7nond 193 9 to to TO cord-282610-zim7nond 193 10 isolate isolate VB cord-282610-zim7nond 193 11 and/or and/or CC cord-282610-zim7nond 193 12 replicate replicate VB cord-282610-zim7nond 193 13 disease disease NN cord-282610-zim7nond 193 14 - - HYPH cord-282610-zim7nond 193 15 induced induce VBN cord-282610-zim7nond 193 16 gut gut NN cord-282610-zim7nond 193 17 microbiome microbiome NN cord-282610-zim7nond 193 18 dysbiosis dysbiosis NN cord-282610-zim7nond 193 19 in in IN cord-282610-zim7nond 193 20 the the DT cord-282610-zim7nond 193 21 face face NN cord-282610-zim7nond 193 22 of of IN cord-282610-zim7nond 193 23 this this DT cord-282610-zim7nond 193 24 " " `` cord-282610-zim7nond 193 25 noise noise NN cord-282610-zim7nond 193 26 . . . cord-282610-zim7nond 193 27 " " '' cord-282610-zim7nond 194 1 For for IN cord-282610-zim7nond 194 2 example example NN cord-282610-zim7nond 194 3 , , , cord-282610-zim7nond 194 4 Frémont Frémont NNP cord-282610-zim7nond 194 5 et et NNP cord-282610-zim7nond 194 6 al al NNP cord-282610-zim7nond 194 7 . . . cord-282610-zim7nond 195 1 ( ( -LRB- cord-282610-zim7nond 195 2 86 86 CD cord-282610-zim7nond 195 3 ) ) -RRB- cord-282610-zim7nond 195 4 found find VBD cord-282610-zim7nond 195 5 that that IN cord-282610-zim7nond 195 6 intestinal intestinal JJ cord-282610-zim7nond 195 7 microbiome microbiome NN cord-282610-zim7nond 195 8 species species NN cord-282610-zim7nond 195 9 composition composition NN cord-282610-zim7nond 195 10 differed differ VBD cord-282610-zim7nond 195 11 between between IN cord-282610-zim7nond 195 12 patients patient NNS cord-282610-zim7nond 195 13 with with IN cord-282610-zim7nond 195 14 ME ME NNP cord-282610-zim7nond 195 15 / / SYM cord-282610-zim7nond 195 16 CFS CFS NNP cord-282610-zim7nond 195 17 and and CC cord-282610-zim7nond 195 18 healthy healthy JJ cord-282610-zim7nond 195 19 controls control NNS cord-282610-zim7nond 195 20 . . . cord-282610-zim7nond 196 1 However however RB cord-282610-zim7nond 196 2 , , , cord-282610-zim7nond 196 3 significant significant JJ cord-282610-zim7nond 196 4 changes change NNS cord-282610-zim7nond 196 5 in in IN cord-282610-zim7nond 196 6 intestinal intestinal JJ cord-282610-zim7nond 196 7 microbiome microbiome NN cord-282610-zim7nond 196 8 composition composition NN cord-282610-zim7nond 196 9 were be VBD cord-282610-zim7nond 196 10 also also RB cord-282610-zim7nond 196 11 identified identify VBN cord-282610-zim7nond 196 12 between between IN cord-282610-zim7nond 196 13 control control NN cord-282610-zim7nond 196 14 subjects subject NNS cord-282610-zim7nond 196 15 from from IN cord-282610-zim7nond 196 16 Norway Norway NNP cord-282610-zim7nond 196 17 and and CC cord-282610-zim7nond 196 18 controls control VBZ cord-282610-zim7nond 196 19 subjects subject NNS cord-282610-zim7nond 196 20 from from IN cord-282610-zim7nond 196 21 Belgium Belgium NNP cord-282610-zim7nond 196 22 . . . cord-282610-zim7nond 197 1 This this DT cord-282610-zim7nond 197 2 variation variation NN cord-282610-zim7nond 197 3 was be VBD cord-282610-zim7nond 197 4 proposed propose VBN cord-282610-zim7nond 197 5 to to TO cord-282610-zim7nond 197 6 arise arise VB cord-282610-zim7nond 197 7 from from IN cord-282610-zim7nond 197 8 differences difference NNS cord-282610-zim7nond 197 9 in in IN cord-282610-zim7nond 197 10 diet diet NN cord-282610-zim7nond 197 11 between between IN cord-282610-zim7nond 197 12 the the DT cord-282610-zim7nond 197 13 two two CD cord-282610-zim7nond 197 14 cultures culture NNS cord-282610-zim7nond 197 15 . . . cord-282610-zim7nond 198 1 Studies study NNS cord-282610-zim7nond 198 2 of of IN cord-282610-zim7nond 198 3 the the DT cord-282610-zim7nond 198 4 ME ME NNP cord-282610-zim7nond 198 5 / / SYM cord-282610-zim7nond 198 6 CFS CFS NNP cord-282610-zim7nond 198 7 blood blood NN cord-282610-zim7nond 198 8 microbiome microbiome NN cord-282610-zim7nond 198 9 may may MD cord-282610-zim7nond 198 10 be be VB cord-282610-zim7nond 198 11 less less RBR cord-282610-zim7nond 198 12 subject subject JJ cord-282610-zim7nond 198 13 to to IN cord-282610-zim7nond 198 14 this this DT cord-282610-zim7nond 198 15 environment environment NN cord-282610-zim7nond 198 16 - - HYPH cord-282610-zim7nond 198 17 induced induce VBN cord-282610-zim7nond 198 18 variability variability NN cord-282610-zim7nond 198 19 . . . cord-282610-zim7nond 199 1 Furthermore furthermore RB cord-282610-zim7nond 199 2 , , , cord-282610-zim7nond 199 3 identification identification NN cord-282610-zim7nond 199 4 of of IN cord-282610-zim7nond 199 5 microbial microbial JJ cord-282610-zim7nond 199 6 and/or and/or CC cord-282610-zim7nond 199 7 viral viral JJ cord-282610-zim7nond 199 8 communities community NNS cord-282610-zim7nond 199 9 in in IN cord-282610-zim7nond 199 10 ME ME NNP cord-282610-zim7nond 199 11 / / SYM cord-282610-zim7nond 199 12 CFS CFS NNP cord-282610-zim7nond 199 13 blood blood NN cord-282610-zim7nond 199 14 would would MD cord-282610-zim7nond 199 15 allow allow VB cord-282610-zim7nond 199 16 for for IN cord-282610-zim7nond 199 17 a a DT cord-282610-zim7nond 199 18 broader broad JJR cord-282610-zim7nond 199 19 picture picture NN cord-282610-zim7nond 199 20 of of IN cord-282610-zim7nond 199 21 possible possible JJ cord-282610-zim7nond 199 22 infectious infectious JJ cord-282610-zim7nond 199 23 and and CC cord-282610-zim7nond 199 24 inflammatory inflammatory JJ cord-282610-zim7nond 199 25 processes process NNS cord-282610-zim7nond 199 26 . . . cord-282610-zim7nond 200 1 For for IN cord-282610-zim7nond 200 2 example example NN cord-282610-zim7nond 200 3 , , , cord-282610-zim7nond 200 4 Giloteaux Giloteaux NNP cord-282610-zim7nond 200 5 et et FW cord-282610-zim7nond 200 6 al al NNP cord-282610-zim7nond 200 7 . . . cord-282610-zim7nond 201 1 ( ( -LRB- cord-282610-zim7nond 201 2 21 21 CD cord-282610-zim7nond 201 3 ) ) -RRB- cord-282610-zim7nond 201 4 found find VBD cord-282610-zim7nond 201 5 that that IN cord-282610-zim7nond 201 6 ME ME NNP cord-282610-zim7nond 201 7 / / SYM cord-282610-zim7nond 201 8 CFS CFS NNP cord-282610-zim7nond 201 9 subjects subject NNS cord-282610-zim7nond 201 10 had have VBD cord-282610-zim7nond 201 11 higher high JJR cord-282610-zim7nond 201 12 levels level NNS cord-282610-zim7nond 201 13 of of IN cord-282610-zim7nond 201 14 bacterial bacterial JJ cord-282610-zim7nond 201 15 lipopolysaccharides lipopolysaccharide NNS cord-282610-zim7nond 201 16 ( ( -LRB- cord-282610-zim7nond 201 17 LPS LPS NNP cord-282610-zim7nond 201 18 ) ) -RRB- cord-282610-zim7nond 201 19 , , , cord-282610-zim7nond 201 20 LPS LPS NNP cord-282610-zim7nond 201 21 - - HYPH cord-282610-zim7nond 201 22 binding bind VBG cord-282610-zim7nond 201 23 proteins protein NNS cord-282610-zim7nond 201 24 and and CC cord-282610-zim7nond 201 25 soluble soluble JJ cord-282610-zim7nond 201 26 CD14 CD14 NNP cord-282610-zim7nond 201 27 in in IN cord-282610-zim7nond 201 28 blood blood NN cord-282610-zim7nond 201 29 . . . cord-282610-zim7nond 202 1 The the DT cord-282610-zim7nond 202 2 team team NN cord-282610-zim7nond 202 3 suggested suggest VBD cord-282610-zim7nond 202 4 that that IN cord-282610-zim7nond 202 5 these these DT cord-282610-zim7nond 202 6 inflammatory inflammatory JJ cord-282610-zim7nond 202 7 markers marker NNS cord-282610-zim7nond 202 8 may may MD cord-282610-zim7nond 202 9 indicate indicate VB cord-282610-zim7nond 202 10 translocation translocation NN cord-282610-zim7nond 202 11 of of IN cord-282610-zim7nond 202 12 gut gut NN cord-282610-zim7nond 202 13 bacteria bacteria NNS cord-282610-zim7nond 202 14 into into IN cord-282610-zim7nond 202 15 the the DT cord-282610-zim7nond 202 16 blood blood NN cord-282610-zim7nond 202 17 . . . cord-282610-zim7nond 203 1 However however RB cord-282610-zim7nond 203 2 , , , cord-282610-zim7nond 203 3 the the DT cord-282610-zim7nond 203 4 markers marker NNS cord-282610-zim7nond 203 5 could could MD cord-282610-zim7nond 203 6 also also RB cord-282610-zim7nond 203 7 reflect reflect VB cord-282610-zim7nond 203 8 the the DT cord-282610-zim7nond 203 9 presence presence NN cord-282610-zim7nond 203 10 of of IN cord-282610-zim7nond 203 11 bacteria bacteria NNS cord-282610-zim7nond 203 12 in in IN cord-282610-zim7nond 203 13 the the DT cord-282610-zim7nond 203 14 blood blood NN cord-282610-zim7nond 203 15 itself -PRON- PRP cord-282610-zim7nond 203 16 . . . cord-282610-zim7nond 204 1 The the DT cord-282610-zim7nond 204 2 blood blood NN cord-282610-zim7nond 204 3 microbiome microbiome NN cord-282610-zim7nond 204 4 can can MD cord-282610-zim7nond 204 5 be be VB cord-282610-zim7nond 204 6 characterized characterize VBN cord-282610-zim7nond 204 7 if if IN cord-282610-zim7nond 204 8 the the DT cord-282610-zim7nond 204 9 microbial microbial JJ cord-282610-zim7nond 204 10 DNA DNA NNP cord-282610-zim7nond 204 11 / / SYM cord-282610-zim7nond 204 12 RNA RNA NNP cord-282610-zim7nond 204 13 in in IN cord-282610-zim7nond 204 14 samples sample NNS cord-282610-zim7nond 204 15 is be VBZ cord-282610-zim7nond 204 16 first first RB cord-282610-zim7nond 204 17 separated separate VBN cord-282610-zim7nond 204 18 from from IN cord-282610-zim7nond 204 19 that that DT cord-282610-zim7nond 204 20 derived derive VBN cord-282610-zim7nond 204 21 from from IN cord-282610-zim7nond 204 22 the the DT cord-282610-zim7nond 204 23 human human JJ cord-282610-zim7nond 204 24 genome genome NN cord-282610-zim7nond 204 25 . . . cord-282610-zim7nond 205 1 Olde Olde NNP cord-282610-zim7nond 205 2 Loohuis Loohuis NNP cord-282610-zim7nond 205 3 et et NNP cord-282610-zim7nond 205 4 al al NNP cord-282610-zim7nond 205 5 . . . cord-282610-zim7nond 206 1 ( ( -LRB- cord-282610-zim7nond 206 2 87 87 CD cord-282610-zim7nond 206 3 ) ) -RRB- cord-282610-zim7nond 206 4 used use VBD cord-282610-zim7nond 206 5 RNA rna NN cord-282610-zim7nond 206 6 sequencing sequencing NN cord-282610-zim7nond 206 7 of of IN cord-282610-zim7nond 206 8 reads read NNS cord-282610-zim7nond 206 9 from from IN cord-282610-zim7nond 206 10 whole whole JJ cord-282610-zim7nond 206 11 blood blood NN cord-282610-zim7nond 206 12 to to TO cord-282610-zim7nond 206 13 analyze analyze VB cord-282610-zim7nond 206 14 microbial microbial JJ cord-282610-zim7nond 206 15 communities community NNS cord-282610-zim7nond 206 16 in in IN cord-282610-zim7nond 206 17 the the DT cord-282610-zim7nond 206 18 blood blood NN cord-282610-zim7nond 206 19 of of IN cord-282610-zim7nond 206 20 almost almost RB cord-282610-zim7nond 206 21 200 200 CD cord-282610-zim7nond 206 22 patients patient NNS cord-282610-zim7nond 206 23 with with IN cord-282610-zim7nond 206 24 three three CD cord-282610-zim7nond 206 25 neurological neurological JJ cord-282610-zim7nond 206 26 conditions condition NNS cord-282610-zim7nond 206 27 : : : cord-282610-zim7nond 206 28 bipolar bipolar JJ cord-282610-zim7nond 206 29 disorder disorder NN cord-282610-zim7nond 206 30 , , , cord-282610-zim7nond 206 31 schizophrenia schizophrenia NN cord-282610-zim7nond 206 32 , , , cord-282610-zim7nond 206 33 and and CC cord-282610-zim7nond 206 34 amyoytrophic amyoytrophic JJ cord-282610-zim7nond 206 35 lateral lateral JJ cord-282610-zim7nond 206 36 sclerosis sclerosis NN cord-282610-zim7nond 206 37 . . . cord-282610-zim7nond 207 1 The the DT cord-282610-zim7nond 207 2 team team NN cord-282610-zim7nond 207 3 identified identify VBD cord-282610-zim7nond 207 4 a a DT cord-282610-zim7nond 207 5 wide wide JJ cord-282610-zim7nond 207 6 range range NN cord-282610-zim7nond 207 7 of of IN cord-282610-zim7nond 207 8 bacterial bacterial JJ cord-282610-zim7nond 207 9 and and CC cord-282610-zim7nond 207 10 archaeal archaeal JJ cord-282610-zim7nond 207 11 phyla phylum NNS cord-282610-zim7nond 207 12 in in IN cord-282610-zim7nond 207 13 subjects subject NNS cord-282610-zim7nond 207 14 with with IN cord-282610-zim7nond 207 15 all all DT cord-282610-zim7nond 207 16 three three CD cord-282610-zim7nond 207 17 disease disease NN cord-282610-zim7nond 207 18 states state NNS cord-282610-zim7nond 207 19 . . . cord-282610-zim7nond 208 1 They -PRON- PRP cord-282610-zim7nond 208 2 observed observe VBD cord-282610-zim7nond 208 3 increased increase VBN cord-282610-zim7nond 208 4 microbial microbial JJ cord-282610-zim7nond 208 5 diversity diversity NN cord-282610-zim7nond 208 6 in in IN cord-282610-zim7nond 208 7 schizophrenia schizophrenia NN cord-282610-zim7nond 208 8 subjects subject NNS cord-282610-zim7nond 208 9 compared compare VBN cord-282610-zim7nond 208 10 to to IN cord-282610-zim7nond 208 11 the the DT cord-282610-zim7nond 208 12 two two CD cord-282610-zim7nond 208 13 other other JJ cord-282610-zim7nond 208 14 groups group NNS cord-282610-zim7nond 208 15 , , , cord-282610-zim7nond 208 16 and and CC cord-282610-zim7nond 208 17 replicated replicate VBD cord-282610-zim7nond 208 18 the the DT cord-282610-zim7nond 208 19 finding finding NN cord-282610-zim7nond 208 20 in in IN cord-282610-zim7nond 208 21 an an DT cord-282610-zim7nond 208 22 independent independent JJ cord-282610-zim7nond 208 23 dataset dataset NN cord-282610-zim7nond 208 24 . . . cord-282610-zim7nond 209 1 Stephen Stephen NNP cord-282610-zim7nond 209 2 Quake Quake NNP cord-282610-zim7nond 209 3 's 's POS cord-282610-zim7nond 209 4 cell cell NN cord-282610-zim7nond 209 5 - - HYPH cord-282610-zim7nond 209 6 free free JJ cord-282610-zim7nond 209 7 DNA dna NN cord-282610-zim7nond 209 8 shotgun shotgun NN cord-282610-zim7nond 209 9 sequencing sequencing NN cord-282610-zim7nond 209 10 technologies technology NNS cord-282610-zim7nond 209 11 can can MD cord-282610-zim7nond 209 12 also also RB cord-282610-zim7nond 209 13 characterize characterize VB cord-282610-zim7nond 209 14 bacterial bacterial JJ cord-282610-zim7nond 209 15 communities community NNS cord-282610-zim7nond 209 16 in in IN cord-282610-zim7nond 209 17 human human JJ cord-282610-zim7nond 209 18 blood blood NN cord-282610-zim7nond 209 19 , , , cord-282610-zim7nond 209 20 and and CC cord-282610-zim7nond 209 21 can can MD cord-282610-zim7nond 209 22 be be VB cord-282610-zim7nond 209 23 additionally additionally RB cord-282610-zim7nond 209 24 extended extend VBN cord-282610-zim7nond 209 25 to to TO cord-282610-zim7nond 209 26 identify identify VB cord-282610-zim7nond 209 27 viruses virus NNS cord-282610-zim7nond 209 28 and and CC cord-282610-zim7nond 209 29 fungi fungus NNS cord-282610-zim7nond 209 30 ( ( -LRB- cord-282610-zim7nond 209 31 14 14 CD cord-282610-zim7nond 209 32 ) ) -RRB- cord-282610-zim7nond 209 33 . . . cord-282610-zim7nond 210 1 Communities community NNS cord-282610-zim7nond 210 2 of of IN cord-282610-zim7nond 210 3 microbes microbe NNS cord-282610-zim7nond 210 4 and and CC cord-282610-zim7nond 210 5 viruses virus NNS cord-282610-zim7nond 210 6 may may MD cord-282610-zim7nond 210 7 also also RB cord-282610-zim7nond 210 8 persist persist VB cord-282610-zim7nond 210 9 in in IN cord-282610-zim7nond 210 10 ME ME NNP cord-282610-zim7nond 210 11 / / SYM cord-282610-zim7nond 210 12 CFS CFS NNP cord-282610-zim7nond 210 13 brain brain NN cord-282610-zim7nond 210 14 tissue tissue NN cord-282610-zim7nond 210 15 . . . cord-282610-zim7nond 211 1 Readhead Readhead NNP cord-282610-zim7nond 211 2 et et NNP cord-282610-zim7nond 211 3 al al NNP cord-282610-zim7nond 211 4 . . . cord-282610-zim7nond 212 1 ( ( -LRB- cord-282610-zim7nond 212 2 88 88 CD cord-282610-zim7nond 212 3 ) ) -RRB- cord-282610-zim7nond 212 4 recently recently RB cord-282610-zim7nond 212 5 detected detect VBD cord-282610-zim7nond 212 6 a a DT cord-282610-zim7nond 212 7 range range NN cord-282610-zim7nond 212 8 of of IN cord-282610-zim7nond 212 9 persistent persistent JJ cord-282610-zim7nond 212 10 viruses virus NNS cord-282610-zim7nond 212 11 in in IN cord-282610-zim7nond 212 12 the the DT cord-282610-zim7nond 212 13 Alzheimer Alzheimer NNP cord-282610-zim7nond 212 14 's 's POS cord-282610-zim7nond 212 15 brain brain NN cord-282610-zim7nond 212 16 . . . cord-282610-zim7nond 213 1 These these DT cord-282610-zim7nond 213 2 included include VBD cord-282610-zim7nond 213 3 herpesviruses herpesviruses NNP cord-282610-zim7nond 213 4 , , , cord-282610-zim7nond 213 5 torque torque NN cord-282610-zim7nond 213 6 teno teno NNP cord-282610-zim7nond 213 7 viruses virus NNS cord-282610-zim7nond 213 8 , , , cord-282610-zim7nond 213 9 adenoviruses adenovirus NNS cord-282610-zim7nond 213 10 , , , cord-282610-zim7nond 213 11 and and CC cord-282610-zim7nond 213 12 coronaviruses coronaviruse NNS cord-282610-zim7nond 213 13 . . . cord-282610-zim7nond 214 1 The the DT cord-282610-zim7nond 214 2 Alzheimer Alzheimer NNP cord-282610-zim7nond 214 3 's 's POS cord-282610-zim7nond 214 4 brain brain NN cord-282610-zim7nond 214 5 has have VBZ cord-282610-zim7nond 214 6 also also RB cord-282610-zim7nond 214 7 been be VBN cord-282610-zim7nond 214 8 shown show VBN cord-282610-zim7nond 214 9 to to TO cord-282610-zim7nond 214 10 harbor harbor VB cord-282610-zim7nond 214 11 bacterial bacterial JJ cord-282610-zim7nond 214 12 and and CC cord-282610-zim7nond 214 13 fungal fungal JJ cord-282610-zim7nond 214 14 communities community NNS cord-282610-zim7nond 214 15 ( ( -LRB- cord-282610-zim7nond 214 16 89 89 CD cord-282610-zim7nond 214 17 , , , cord-282610-zim7nond 214 18 90 90 CD cord-282610-zim7nond 214 19 ) ) -RRB- cord-282610-zim7nond 214 20 . . . cord-282610-zim7nond 215 1 Branton Branton NNP cord-282610-zim7nond 215 2 et et NNP cord-282610-zim7nond 215 3 al al NNP cord-282610-zim7nond 215 4 . . . cord-282610-zim7nond 216 1 ( ( -LRB- cord-282610-zim7nond 216 2 91 91 CD cord-282610-zim7nond 216 3 ) ) -RRB- cord-282610-zim7nond 216 4 identified identify VBD cord-282610-zim7nond 216 5 hundreds hundred NNS cord-282610-zim7nond 216 6 of of IN cord-282610-zim7nond 216 7 bacteria bacteria NNS cord-282610-zim7nond 216 8 and and CC cord-282610-zim7nond 216 9 bacteriophage bacteriophage NN cord-282610-zim7nond 216 10 - - HYPH cord-282610-zim7nond 216 11 derived derive VBN cord-282610-zim7nond 216 12 samples sample NNS cord-282610-zim7nond 216 13 in in IN cord-282610-zim7nond 216 14 brain brain NN cord-282610-zim7nond 216 15 tissue tissue NN cord-282610-zim7nond 216 16 removed remove VBN cord-282610-zim7nond 216 17 from from IN cord-282610-zim7nond 216 18 patients patient NNS cord-282610-zim7nond 216 19 with with IN cord-282610-zim7nond 216 20 epilepsy epilepsy NN cord-282610-zim7nond 216 21 , , , cord-282610-zim7nond 216 22 and and CC cord-282610-zim7nond 216 23 in in IN cord-282610-zim7nond 216 24 brain brain NN cord-282610-zim7nond 216 25 samples sample NNS cord-282610-zim7nond 216 26 obtained obtain VBN cord-282610-zim7nond 216 27 from from IN cord-282610-zim7nond 216 28 HIV HIV NNP cord-282610-zim7nond 216 29 / / SYM cord-282610-zim7nond 216 30 AIDS AIDS NNP cord-282610-zim7nond 216 31 patients patient NNS cord-282610-zim7nond 216 32 after after IN cord-282610-zim7nond 216 33 autopsy autopsy JJ cord-282610-zim7nond 216 34 . . . cord-282610-zim7nond 217 1 In in IN cord-282610-zim7nond 217 2 fact fact NN cord-282610-zim7nond 217 3 , , , cord-282610-zim7nond 217 4 studies study NNS cord-282610-zim7nond 217 5 of of IN cord-282610-zim7nond 217 6 the the DT cord-282610-zim7nond 217 7 virome virome NNP cord-282610-zim7nond 217 8 provide provide VBP cord-282610-zim7nond 217 9 significantly significantly RB cord-282610-zim7nond 217 10 extended extend VBN cord-282610-zim7nond 217 11 context context NN cord-282610-zim7nond 217 12 on on IN cord-282610-zim7nond 217 13 microbiome microbiome NN cord-282610-zim7nond 217 14 community community NN cord-282610-zim7nond 217 15 dynamics dynamic NNS cord-282610-zim7nond 217 16 and and CC cord-282610-zim7nond 217 17 disease disease NN cord-282610-zim7nond 217 18 processes process NNS cord-282610-zim7nond 217 19 . . . cord-282610-zim7nond 218 1 This this DT cord-282610-zim7nond 218 2 is be VBZ cord-282610-zim7nond 218 3 because because IN cord-282610-zim7nond 218 4 bacteriophages bacteriophage NNS cord-282610-zim7nond 218 5 ( ( -LRB- cord-282610-zim7nond 218 6 phages phage NNS cord-282610-zim7nond 218 7 ) ) -RRB- cord-282610-zim7nond 218 8 infect infect VBP cord-282610-zim7nond 218 9 , , , cord-282610-zim7nond 218 10 and and CC cord-282610-zim7nond 218 11 subsequently subsequently RB cord-282610-zim7nond 218 12 modulate modulate VB cord-282610-zim7nond 218 13 the the DT cord-282610-zim7nond 218 14 activity activity NN cord-282610-zim7nond 218 15 of of IN cord-282610-zim7nond 218 16 the the DT cord-282610-zim7nond 218 17 bacterial bacterial JJ cord-282610-zim7nond 218 18 microbiome microbiome NN cord-282610-zim7nond 218 19 ( ( -LRB- cord-282610-zim7nond 218 20 75 75 CD cord-282610-zim7nond 218 21 ) ) -RRB- cord-282610-zim7nond 218 22 . . . cord-282610-zim7nond 219 1 For for IN cord-282610-zim7nond 219 2 example example NN cord-282610-zim7nond 219 3 , , , cord-282610-zim7nond 219 4 Duerkop Duerkop NNP cord-282610-zim7nond 219 5 et et NNP cord-282610-zim7nond 219 6 al al NNP cord-282610-zim7nond 219 7 . . . cord-282610-zim7nond 220 1 ( ( -LRB- cord-282610-zim7nond 220 2 92 92 CD cord-282610-zim7nond 220 3 ) ) -RRB- cord-282610-zim7nond 220 4 characterized characterize VBD cord-282610-zim7nond 220 5 the the DT cord-282610-zim7nond 220 6 intestinal intestinal JJ cord-282610-zim7nond 220 7 virome virome NN cord-282610-zim7nond 220 8 in in IN cord-282610-zim7nond 220 9 a a DT cord-282610-zim7nond 220 10 model model NN cord-282610-zim7nond 220 11 of of IN cord-282610-zim7nond 220 12 T t NN cord-282610-zim7nond 220 13 - - HYPH cord-282610-zim7nond 220 14 cell cell NN cord-282610-zim7nond 220 15 - - HYPH cord-282610-zim7nond 220 16 mediated mediate VBN cord-282610-zim7nond 220 17 murine murine JJ cord-282610-zim7nond 220 18 colitis colitis NN cord-282610-zim7nond 220 19 . . . cord-282610-zim7nond 221 1 The the DT cord-282610-zim7nond 221 2 intestinal intestinal JJ cord-282610-zim7nond 221 3 phage phage NN cord-282610-zim7nond 221 4 population population NN cord-282610-zim7nond 221 5 changed change VBN cord-282610-zim7nond 221 6 in in IN cord-282610-zim7nond 221 7 colitis colitis NN cord-282610-zim7nond 221 8 , , , cord-282610-zim7nond 221 9 and and CC cord-282610-zim7nond 221 10 transitioned transition VBD cord-282610-zim7nond 221 11 from from IN cord-282610-zim7nond 221 12 an an DT cord-282610-zim7nond 221 13 ordered order VBN cord-282610-zim7nond 221 14 state state NN cord-282610-zim7nond 221 15 to to IN cord-282610-zim7nond 221 16 a a DT cord-282610-zim7nond 221 17 stochastic stochastic JJ cord-282610-zim7nond 221 18 dysbiosis dysbiosis NN cord-282610-zim7nond 221 19 . . . cord-282610-zim7nond 222 1 Phage phage NN cord-282610-zim7nond 222 2 populations population NNS cord-282610-zim7nond 222 3 that that WDT cord-282610-zim7nond 222 4 expanded expand VBD cord-282610-zim7nond 222 5 during during IN cord-282610-zim7nond 222 6 colitis colitis NN cord-282610-zim7nond 222 7 were be VBD cord-282610-zim7nond 222 8 frequently frequently RB cord-282610-zim7nond 222 9 connected connect VBN cord-282610-zim7nond 222 10 to to IN cord-282610-zim7nond 222 11 bacterial bacterial JJ cord-282610-zim7nond 222 12 hosts host NNS cord-282610-zim7nond 222 13 that that WDT cord-282610-zim7nond 222 14 benefit benefit VBP cord-282610-zim7nond 222 15 from from IN cord-282610-zim7nond 222 16 or or CC cord-282610-zim7nond 222 17 are be VBP cord-282610-zim7nond 222 18 linked link VBN cord-282610-zim7nond 222 19 to to IN cord-282610-zim7nond 222 20 intestinal intestinal JJ cord-282610-zim7nond 222 21 inflammation inflammation NN cord-282610-zim7nond 222 22 . . . cord-282610-zim7nond 223 1 Tetz Tetz NNP cord-282610-zim7nond 223 2 et et NNP cord-282610-zim7nond 223 3 al al NNP cord-282610-zim7nond 223 4 . . . cord-282610-zim7nond 224 1 ( ( -LRB- cord-282610-zim7nond 224 2 93 93 CD cord-282610-zim7nond 224 3 ) ) -RRB- cord-282610-zim7nond 224 4 identified identify VBD cord-282610-zim7nond 224 5 changes change NNS cord-282610-zim7nond 224 6 in in IN cord-282610-zim7nond 224 7 the the DT cord-282610-zim7nond 224 8 Parkinson Parkinson NNP cord-282610-zim7nond 224 9 's 's POS cord-282610-zim7nond 224 10 gut gut NN cord-282610-zim7nond 224 11 bacteriophage bacteriophage NN cord-282610-zim7nond 224 12 community community NN cord-282610-zim7nond 224 13 . . . cord-282610-zim7nond 225 1 These these DT cord-282610-zim7nond 225 2 included include VBD cord-282610-zim7nond 225 3 shifts shift NNS cord-282610-zim7nond 225 4 in in IN cord-282610-zim7nond 225 5 the the DT cord-282610-zim7nond 225 6 phage phage NN cord-282610-zim7nond 225 7 / / SYM cord-282610-zim7nond 225 8 bacteria bacteria NNS cord-282610-zim7nond 225 9 ratio ratio NN cord-282610-zim7nond 225 10 of of IN cord-282610-zim7nond 225 11 bacteria bacteria NNS cord-282610-zim7nond 225 12 known know VBN cord-282610-zim7nond 225 13 to to TO cord-282610-zim7nond 225 14 produce produce VB cord-282610-zim7nond 225 15 dopamine dopamine NN cord-282610-zim7nond 225 16 . . . cord-282610-zim7nond 226 1 Species species NN cord-282610-zim7nond 226 2 - - HYPH cord-282610-zim7nond 226 3 level level NN cord-282610-zim7nond 226 4 studies study NNS cord-282610-zim7nond 226 5 of of IN cord-282610-zim7nond 226 6 the the DT cord-282610-zim7nond 226 7 microbiome microbiome NN cord-282610-zim7nond 226 8 are be VBP cord-282610-zim7nond 226 9 also also RB cord-282610-zim7nond 226 10 greatly greatly RB cord-282610-zim7nond 226 11 enhanced enhance VBN cord-282610-zim7nond 226 12 by by IN cord-282610-zim7nond 226 13 analyses analysis NNS cord-282610-zim7nond 226 14 that that WDT cord-282610-zim7nond 226 15 provide provide VBP cord-282610-zim7nond 226 16 further further JJ cord-282610-zim7nond 226 17 context context NN cord-282610-zim7nond 226 18 on on IN cord-282610-zim7nond 226 19 disease disease NN cord-282610-zim7nond 226 20 activity activity NN cord-282610-zim7nond 226 21 . . . cord-282610-zim7nond 227 1 This this DT cord-282610-zim7nond 227 2 is be VBZ cord-282610-zim7nond 227 3 an an DT cord-282610-zim7nond 227 4 important important JJ cord-282610-zim7nond 227 5 consideration consideration NN cord-282610-zim7nond 227 6 because because IN cord-282610-zim7nond 227 7 , , , cord-282610-zim7nond 227 8 in in IN cord-282610-zim7nond 227 9 theory theory NN cord-282610-zim7nond 227 10 , , , cord-282610-zim7nond 227 11 the the DT cord-282610-zim7nond 227 12 microbiome microbiome NN cord-282610-zim7nond 227 13 of of IN cord-282610-zim7nond 227 14 a a DT cord-282610-zim7nond 227 15 patient patient NN cord-282610-zim7nond 227 16 with with IN cord-282610-zim7nond 227 17 ME ME NNP cord-282610-zim7nond 227 18 / / SYM cord-282610-zim7nond 227 19 CFS CFS NNP cord-282610-zim7nond 227 20 could could MD cord-282610-zim7nond 227 21 harbor harbor VB cord-282610-zim7nond 227 22 the the DT cord-282610-zim7nond 227 23 exact exact JJ cord-282610-zim7nond 227 24 same same JJ cord-282610-zim7nond 227 25 microbial microbial NN cord-282610-zim7nond 227 26 , , , cord-282610-zim7nond 227 27 viral viral JJ cord-282610-zim7nond 227 28 and/or and/or CC cord-282610-zim7nond 227 29 fungal fungal JJ cord-282610-zim7nond 227 30 species specie NNS cord-282610-zim7nond 227 31 as as IN cord-282610-zim7nond 227 32 that that DT cord-282610-zim7nond 227 33 of of IN cord-282610-zim7nond 227 34 a a DT cord-282610-zim7nond 227 35 healthy healthy JJ cord-282610-zim7nond 227 36 subject subject NN cord-282610-zim7nond 227 37 . . . cord-282610-zim7nond 228 1 Yet yet RB cord-282610-zim7nond 228 2 many many JJ cord-282610-zim7nond 228 3 of of IN cord-282610-zim7nond 228 4 these these DT cord-282610-zim7nond 228 5 organisms organism NNS cord-282610-zim7nond 228 6 could could MD cord-282610-zim7nond 228 7 be be VB cord-282610-zim7nond 228 8 acting act VBG cord-282610-zim7nond 228 9 very very RB cord-282610-zim7nond 228 10 differently differently RB cord-282610-zim7nond 228 11 in in IN cord-282610-zim7nond 228 12 patients patient NNS cord-282610-zim7nond 228 13 with with IN cord-282610-zim7nond 228 14 the the DT cord-282610-zim7nond 228 15 disease disease NN cord-282610-zim7nond 228 16 . . . cord-282610-zim7nond 229 1 Species species NN cord-282610-zim7nond 229 2 - - HYPH cord-282610-zim7nond 229 3 level level NN cord-282610-zim7nond 229 4 analyses analysis NNS cord-282610-zim7nond 229 5 of of IN cord-282610-zim7nond 229 6 the the DT cord-282610-zim7nond 229 7 ME ME NNP cord-282610-zim7nond 229 8 / / SYM cord-282610-zim7nond 229 9 CFS CFS NNP cord-282610-zim7nond 229 10 microbiome microbiome NN cord-282610-zim7nond 229 11 must must MD cord-282610-zim7nond 229 12 subsequently subsequently RB cord-282610-zim7nond 229 13 be be VB cord-282610-zim7nond 229 14 accompanied accompany VBN cord-282610-zim7nond 229 15 by by IN cord-282610-zim7nond 229 16 studies study NNS cord-282610-zim7nond 229 17 that that WDT cord-282610-zim7nond 229 18 characterize characterize VBP cord-282610-zim7nond 229 19 microbial microbial JJ cord-282610-zim7nond 229 20 and and CC cord-282610-zim7nond 229 21 viral viral JJ cord-282610-zim7nond 229 22 gene gene NN cord-282610-zim7nond 229 23 expression expression NN cord-282610-zim7nond 229 24 and/or and/or CC cord-282610-zim7nond 229 25 metabolism metabolism NN cord-282610-zim7nond 229 26 . . . cord-282610-zim7nond 230 1 Since since IN cord-282610-zim7nond 230 2 many many JJ cord-282610-zim7nond 230 3 of of IN cord-282610-zim7nond 230 4 the the DT cord-282610-zim7nond 230 5 proteins protein NNS cord-282610-zim7nond 230 6 and and CC cord-282610-zim7nond 230 7 metabolites metabolite NNS cord-282610-zim7nond 230 8 in in IN cord-282610-zim7nond 230 9 the the DT cord-282610-zim7nond 230 10 human human JJ cord-282610-zim7nond 230 11 holobiont holobiont NN cord-282610-zim7nond 230 12 are be VBP cord-282610-zim7nond 230 13 microbial microbial JJ cord-282610-zim7nond 230 14 in in IN cord-282610-zim7nond 230 15 origin origin NN cord-282610-zim7nond 230 16 , , , cord-282610-zim7nond 230 17 composition composition NN cord-282610-zim7nond 230 18 of of IN cord-282610-zim7nond 230 19 the the DT cord-282610-zim7nond 230 20 ME ME NNP cord-282610-zim7nond 230 21 / / SYM cord-282610-zim7nond 230 22 CFS CFS NNP cord-282610-zim7nond 230 23 proteome proteome NN cord-282610-zim7nond 230 24 and and CC cord-282610-zim7nond 230 25 metabolome metabolome NN cord-282610-zim7nond 230 26 change change NN cord-282610-zim7nond 230 27 with with IN cord-282610-zim7nond 230 28 microbiome microbiome NN cord-282610-zim7nond 230 29 species specie NNS cord-282610-zim7nond 230 30 composition composition NN cord-282610-zim7nond 230 31 . . . cord-282610-zim7nond 231 1 Proteome Proteome NNP cord-282610-zim7nond 231 2 and and CC cord-282610-zim7nond 231 3 metabolome metabolome NN cord-282610-zim7nond 231 4 analyses analysis NNS cord-282610-zim7nond 231 5 additionally additionally RB cord-282610-zim7nond 231 6 reflect reflect VBP cord-282610-zim7nond 231 7 microbiome microbiome NN cord-282610-zim7nond 231 8 activity activity NN cord-282610-zim7nond 231 9 . . . cord-282610-zim7nond 232 1 This this DT cord-282610-zim7nond 232 2 is be VBZ cord-282610-zim7nond 232 3 because because IN cord-282610-zim7nond 232 4 microbes microbe NNS cord-282610-zim7nond 232 5 and and CC cord-282610-zim7nond 232 6 viruses virus NNS cord-282610-zim7nond 232 7 frequently frequently RB cord-282610-zim7nond 232 8 alter alter VBP cord-282610-zim7nond 232 9 their -PRON- PRP$ cord-282610-zim7nond 232 10 gene gene NN cord-282610-zim7nond 232 11 expression expression NN cord-282610-zim7nond 232 12 in in IN cord-282610-zim7nond 232 13 ways way NNS cord-282610-zim7nond 232 14 that that WDT cord-282610-zim7nond 232 15 cause cause VBP cord-282610-zim7nond 232 16 them -PRON- PRP cord-282610-zim7nond 232 17 to to TO cord-282610-zim7nond 232 18 express express VB cord-282610-zim7nond 232 19 different different JJ cord-282610-zim7nond 232 20 proteins protein NNS cord-282610-zim7nond 232 21 and and CC cord-282610-zim7nond 232 22 metabolites metabolite NNS cord-282610-zim7nond 232 23 over over IN cord-282610-zim7nond 232 24 time time NN cord-282610-zim7nond 232 25 . . . cord-282610-zim7nond 233 1 The the DT cord-282610-zim7nond 233 2 human human JJ cord-282610-zim7nond 233 3 genome genome NN cord-282610-zim7nond 233 4 and and CC cord-282610-zim7nond 233 5 related relate VBN cord-282610-zim7nond 233 6 epigenetic epigenetic JJ cord-282610-zim7nond 233 7 changes change NNS cord-282610-zim7nond 233 8 also also RB cord-282610-zim7nond 233 9 contribute contribute VBP cord-282610-zim7nond 233 10 to to IN cord-282610-zim7nond 233 11 the the DT cord-282610-zim7nond 233 12 metabolic metabolic JJ cord-282610-zim7nond 233 13 diversity diversity NN cord-282610-zim7nond 233 14 , , , cord-282610-zim7nond 233 15 although although IN cord-282610-zim7nond 233 16 the the DT cord-282610-zim7nond 233 17 high high JJ cord-282610-zim7nond 233 18 level level NN cord-282610-zim7nond 233 19 of of IN cord-282610-zim7nond 233 20 redundancy redundancy NN cord-282610-zim7nond 233 21 between between IN cord-282610-zim7nond 233 22 human human JJ cord-282610-zim7nond 233 23 and and CC cord-282610-zim7nond 233 24 microbial microbial JJ cord-282610-zim7nond 233 25 metabolites metabolite NNS cord-282610-zim7nond 233 26 can can MD cord-282610-zim7nond 233 27 make make VB cord-282610-zim7nond 233 28 the the DT cord-282610-zim7nond 233 29 origin origin NN cord-282610-zim7nond 233 30 of of IN cord-282610-zim7nond 233 31 these these DT cord-282610-zim7nond 233 32 associations association NNS cord-282610-zim7nond 233 33 hard hard JJ cord-282610-zim7nond 233 34 to to TO cord-282610-zim7nond 233 35 pinpoint pinpoint VB cord-282610-zim7nond 233 36 . . . cord-282610-zim7nond 234 1 Schutzer Schutzer NNP cord-282610-zim7nond 234 2 et et FW cord-282610-zim7nond 234 3 al al NNP cord-282610-zim7nond 234 4 . . . cord-282610-zim7nond 235 1 ( ( -LRB- cord-282610-zim7nond 235 2 94 94 CD cord-282610-zim7nond 235 3 ) ) -RRB- cord-282610-zim7nond 235 4 demonstrated demonstrate VBD cord-282610-zim7nond 235 5 that that IN cord-282610-zim7nond 235 6 the the DT cord-282610-zim7nond 235 7 ME ME NNP cord-282610-zim7nond 235 8 / / SYM cord-282610-zim7nond 235 9 CFS cfs NN cord-282610-zim7nond 235 10 cerebrospinal cerebrospinal NN cord-282610-zim7nond 235 11 proteome proteome NN cord-282610-zim7nond 235 12 differs differ VBZ cord-282610-zim7nond 235 13 substantially substantially RB cord-282610-zim7nond 235 14 from from IN cord-282610-zim7nond 235 15 that that DT cord-282610-zim7nond 235 16 of of IN cord-282610-zim7nond 235 17 healthy healthy JJ cord-282610-zim7nond 235 18 controls control NNS cord-282610-zim7nond 235 19 ( ( -LRB- cord-282610-zim7nond 235 20 Figure figure NN cord-282610-zim7nond 235 21 2 2 CD cord-282610-zim7nond 235 22 ) ) -RRB- cord-282610-zim7nond 235 23 . . . cord-282610-zim7nond 236 1 Indeed indeed RB cord-282610-zim7nond 236 2 , , , cord-282610-zim7nond 236 3 738 738 CD cord-282610-zim7nond 236 4 of of IN cord-282610-zim7nond 236 5 2,783 2,783 CD cord-282610-zim7nond 236 6 identified identify VBN cord-282610-zim7nond 236 7 proteins protein NNS cord-282610-zim7nond 236 8 ( ( -LRB- cord-282610-zim7nond 236 9 26.5 26.5 CD cord-282610-zim7nond 236 10 % % NN cord-282610-zim7nond 236 11 ) ) -RRB- cord-282610-zim7nond 236 12 were be VBD cord-282610-zim7nond 236 13 unique unique JJ cord-282610-zim7nond 236 14 to to IN cord-282610-zim7nond 236 15 patients patient NNS cord-282610-zim7nond 236 16 with with IN cord-282610-zim7nond 236 17 ME ME NNP cord-282610-zim7nond 236 18 / / SYM cord-282610-zim7nond 236 19 CFS CFS NNP cord-282610-zim7nond 236 20 , , , cord-282610-zim7nond 236 21 providing provide VBG cord-282610-zim7nond 236 22 strong strong JJ cord-282610-zim7nond 236 23 evidence evidence NN cord-282610-zim7nond 236 24 that that IN cord-282610-zim7nond 236 25 ME ME NNP cord-282610-zim7nond 236 26 / / SYM cord-282610-zim7nond 236 27 CFS CFS NNP cord-282610-zim7nond 236 28 is be VBZ cord-282610-zim7nond 236 29 indeed indeed RB cord-282610-zim7nond 236 30 characterized characterize VBN cord-282610-zim7nond 236 31 by by IN cord-282610-zim7nond 236 32 microbiome microbiome NN cord-282610-zim7nond 236 33 dysbiosis dysbiosis NN cord-282610-zim7nond 236 34 in in IN cord-282610-zim7nond 236 35 tissue tissue NN cord-282610-zim7nond 236 36 and and CC cord-282610-zim7nond 236 37 blood blood NN cord-282610-zim7nond 236 38 . . . cord-282610-zim7nond 237 1 Composition composition NN cord-282610-zim7nond 237 2 of of IN cord-282610-zim7nond 237 3 the the DT cord-282610-zim7nond 237 4 blood blood NN cord-282610-zim7nond 237 5 metabolome metabolome NN cord-282610-zim7nond 237 6 has have VBZ cord-282610-zim7nond 237 7 also also RB cord-282610-zim7nond 237 8 been be VBN cord-282610-zim7nond 237 9 shown show VBN cord-282610-zim7nond 237 10 to to TO cord-282610-zim7nond 237 11 shift shift VB cord-282610-zim7nond 237 12 in in IN cord-282610-zim7nond 237 13 ME ME NNP cord-282610-zim7nond 237 14 / / SYM cord-282610-zim7nond 237 15 CFS CFS NNP cord-282610-zim7nond 237 16 . . . cord-282610-zim7nond 238 1 One one CD cord-282610-zim7nond 238 2 such such JJ cord-282610-zim7nond 238 3 study study NN cord-282610-zim7nond 238 4 reported report VBD cord-282610-zim7nond 238 5 elevated elevated JJ cord-282610-zim7nond 238 6 plasma plasma NN cord-282610-zim7nond 238 7 levels level NNS cord-282610-zim7nond 238 8 of of IN cord-282610-zim7nond 238 9 choline choline NN cord-282610-zim7nond 238 10 , , , cord-282610-zim7nond 238 11 carnitine carnitine NN cord-282610-zim7nond 238 12 , , , cord-282610-zim7nond 238 13 and and CC cord-282610-zim7nond 238 14 complex complex JJ cord-282610-zim7nond 238 15 lipid lipid NN cord-282610-zim7nond 238 16 metabolites metabolite NNS cord-282610-zim7nond 238 17 in in IN cord-282610-zim7nond 238 18 ME ME NNP cord-282610-zim7nond 238 19 / / SYM cord-282610-zim7nond 238 20 CFS CFS NNP cord-282610-zim7nond 238 21 patients patient NNS cord-282610-zim7nond 238 22 ( ( -LRB- cord-282610-zim7nond 238 23 84 84 CD cord-282610-zim7nond 238 24 ) ) -RRB- cord-282610-zim7nond 238 25 . . . cord-282610-zim7nond 239 1 Another another DT cord-282610-zim7nond 239 2 analysis analysis NN cord-282610-zim7nond 239 3 demonstrated demonstrate VBD cord-282610-zim7nond 239 4 a a DT cord-282610-zim7nond 239 5 sustained sustain VBN cord-282610-zim7nond 239 6 hypo hypo JJ cord-282610-zim7nond 239 7 - - JJ cord-282610-zim7nond 239 8 metabolic metabolic JJ cord-282610-zim7nond 239 9 response response NN cord-282610-zim7nond 239 10 in in IN cord-282610-zim7nond 239 11 patients patient NNS cord-282610-zim7nond 239 12 with with IN cord-282610-zim7nond 239 13 the the DT cord-282610-zim7nond 239 14 disease disease NN cord-282610-zim7nond 239 15 ( ( -LRB- cord-282610-zim7nond 239 16 95 95 CD cord-282610-zim7nond 239 17 ) ) -RRB- cord-282610-zim7nond 239 18 . . . cord-282610-zim7nond 240 1 This this DT cord-282610-zim7nond 240 2 dour dour JJ cord-282610-zim7nond 240 3 - - HYPH cord-282610-zim7nond 240 4 like like JJ cord-282610-zim7nond 240 5 state state NN cord-282610-zim7nond 240 6 can can MD cord-282610-zim7nond 240 7 be be VB cord-282610-zim7nond 240 8 driven drive VBN cord-282610-zim7nond 240 9 by by IN cord-282610-zim7nond 240 10 exposure exposure NN cord-282610-zim7nond 240 11 to to IN cord-282610-zim7nond 240 12 adverse adverse JJ cord-282610-zim7nond 240 13 environmental environmental JJ cord-282610-zim7nond 240 14 conditions condition NNS cord-282610-zim7nond 240 15 , , , cord-282610-zim7nond 240 16 as as IN cord-282610-zim7nond 240 17 would would MD cord-282610-zim7nond 240 18 be be VB cord-282610-zim7nond 240 19 expected expect VBN cord-282610-zim7nond 240 20 if if IN cord-282610-zim7nond 240 21 the the DT cord-282610-zim7nond 240 22 ME ME NNP cord-282610-zim7nond 240 23 / / SYM cord-282610-zim7nond 240 24 CFS CFS NNP cord-282610-zim7nond 240 25 immune immune JJ cord-282610-zim7nond 240 26 system system NN cord-282610-zim7nond 240 27 struggles struggle VBZ cord-282610-zim7nond 240 28 to to TO cord-282610-zim7nond 240 29 manage manage VB cord-282610-zim7nond 240 30 microbiome microbiome NN cord-282610-zim7nond 240 31 dysbiosis dysbiosis NN cord-282610-zim7nond 240 32 and and CC cord-282610-zim7nond 240 33 associated associate VBN cord-282610-zim7nond 240 34 pathogens pathogen NNS cord-282610-zim7nond 240 35 . . . cord-282610-zim7nond 241 1 Studies study NNS cord-282610-zim7nond 241 2 of of IN cord-282610-zim7nond 241 3 the the DT cord-282610-zim7nond 241 4 metabolome metabolome NN cord-282610-zim7nond 241 5 are be VBP cord-282610-zim7nond 241 6 often often RB cord-282610-zim7nond 241 7 conducted conduct VBN cord-282610-zim7nond 241 8 in in IN cord-282610-zim7nond 241 9 an an DT cord-282610-zim7nond 241 10 attempt attempt NN cord-282610-zim7nond 241 11 to to TO cord-282610-zim7nond 241 12 identify identify VB cord-282610-zim7nond 241 13 disease disease NN cord-282610-zim7nond 241 14 - - HYPH cord-282610-zim7nond 241 15 specific specific JJ cord-282610-zim7nond 241 16 biomarkers biomarker NNS cord-282610-zim7nond 241 17 . . . cord-282610-zim7nond 242 1 However however RB cord-282610-zim7nond 242 2 , , , cord-282610-zim7nond 242 3 the the DT cord-282610-zim7nond 242 4 metabolome metabolome NN cord-282610-zim7nond 242 5 can can MD cord-282610-zim7nond 242 6 also also RB cord-282610-zim7nond 242 7 be be VB cord-282610-zim7nond 242 8 screened screen VBN cord-282610-zim7nond 242 9 for for IN cord-282610-zim7nond 242 10 metabolites metabolite NNS cord-282610-zim7nond 242 11 that that WDT cord-282610-zim7nond 242 12 directly directly RB cord-282610-zim7nond 242 13 induce induce VBP cord-282610-zim7nond 242 14 or or CC cord-282610-zim7nond 242 15 suppress suppress VB cord-282610-zim7nond 242 16 biological biological JJ cord-282610-zim7nond 242 17 function function NN cord-282610-zim7nond 242 18 in in IN cord-282610-zim7nond 242 19 patients patient NNS cord-282610-zim7nond 242 20 with with IN cord-282610-zim7nond 242 21 a a DT cord-282610-zim7nond 242 22 given give VBN cord-282610-zim7nond 242 23 illness illness NN cord-282610-zim7nond 242 24 . . . cord-282610-zim7nond 243 1 These these DT cord-282610-zim7nond 243 2 studies study NNS cord-282610-zim7nond 243 3 help help VBP cord-282610-zim7nond 243 4 dissociate dissociate VB cord-282610-zim7nond 243 5 cause cause NN cord-282610-zim7nond 243 6 from from IN cord-282610-zim7nond 243 7 effect effect NN cord-282610-zim7nond 243 8 and and CC cord-282610-zim7nond 243 9 allow allow VB cord-282610-zim7nond 243 10 for for IN cord-282610-zim7nond 243 11 possible possible JJ cord-282610-zim7nond 243 12 modulation modulation NN cord-282610-zim7nond 243 13 of of IN cord-282610-zim7nond 243 14 disease disease NN cord-282610-zim7nond 243 15 phenotype phenotype NN cord-282610-zim7nond 243 16 . . . cord-282610-zim7nond 244 1 For for IN cord-282610-zim7nond 244 2 example example NN cord-282610-zim7nond 244 3 , , , cord-282610-zim7nond 244 4 Johnson Johnson NNP cord-282610-zim7nond 244 5 et et NNP cord-282610-zim7nond 244 6 al al NNP cord-282610-zim7nond 244 7 . . . cord-282610-zim7nond 245 1 ( ( -LRB- cord-282610-zim7nond 245 2 96 96 CD cord-282610-zim7nond 245 3 ) ) -RRB- cord-282610-zim7nond 245 4 investigated investigate VBD cord-282610-zim7nond 245 5 the the DT cord-282610-zim7nond 245 6 metabolic metabolic JJ cord-282610-zim7nond 245 7 influence influence NN cord-282610-zim7nond 245 8 of of IN cord-282610-zim7nond 245 9 microbial microbial JJ cord-282610-zim7nond 245 10 biofilms biofilm NNS cord-282610-zim7nond 245 11 on on IN cord-282610-zim7nond 245 12 colon colon NN cord-282610-zim7nond 245 13 cancer cancer NN cord-282610-zim7nond 245 14 tissue tissue NN cord-282610-zim7nond 245 15 and and CC cord-282610-zim7nond 245 16 related related JJ cord-282610-zim7nond 245 17 cancer cancer NN cord-282610-zim7nond 245 18 occurrence occurrence NN cord-282610-zim7nond 245 19 . . . cord-282610-zim7nond 246 1 They -PRON- PRP cord-282610-zim7nond 246 2 found find VBD cord-282610-zim7nond 246 3 that that IN cord-282610-zim7nond 246 4 up up IN cord-282610-zim7nond 246 5 - - HYPH cord-282610-zim7nond 246 6 regulation regulation NN cord-282610-zim7nond 246 7 of of IN cord-282610-zim7nond 246 8 a a DT cord-282610-zim7nond 246 9 biofilm biofilm NN cord-282610-zim7nond 246 10 - - HYPH cord-282610-zim7nond 246 11 derived derive VBN cord-282610-zim7nond 246 12 polyamide polyamide NN cord-282610-zim7nond 246 13 metabolite metabolite NN cord-282610-zim7nond 246 14 enhanced enhance VBD cord-282610-zim7nond 246 15 both both DT cord-282610-zim7nond 246 16 biofilm biofilm NN cord-282610-zim7nond 246 17 formation formation NN cord-282610-zim7nond 246 18 and and CC cord-282610-zim7nond 246 19 cancer cancer NN cord-282610-zim7nond 246 20 growth growth NN cord-282610-zim7nond 246 21 . . . cord-282610-zim7nond 247 1 Studies study NNS cord-282610-zim7nond 247 2 of of IN cord-282610-zim7nond 247 3 microbiome microbiome NN cord-282610-zim7nond 247 4 activity activity NN cord-282610-zim7nond 247 5 must must MD cord-282610-zim7nond 247 6 account account VB cord-282610-zim7nond 247 7 for for IN cord-282610-zim7nond 247 8 the the DT cord-282610-zim7nond 247 9 fact fact NN cord-282610-zim7nond 247 10 that that IN cord-282610-zim7nond 247 11 pathogens pathogen NNS cord-282610-zim7nond 247 12 detected detect VBN cord-282610-zim7nond 247 13 in in IN cord-282610-zim7nond 247 14 patients patient NNS cord-282610-zim7nond 247 15 with with IN cord-282610-zim7nond 247 16 ME ME NNP cord-282610-zim7nond 247 17 / / SYM cord-282610-zim7nond 247 18 CFS CFS NNP cord-282610-zim7nond 247 19 are be VBP cord-282610-zim7nond 247 20 also also RB cord-282610-zim7nond 247 21 regularly regularly RB cord-282610-zim7nond 247 22 identified identify VBN cord-282610-zim7nond 247 23 in in IN cord-282610-zim7nond 247 24 healthy healthy JJ cord-282610-zim7nond 247 25 subjects subject NNS cord-282610-zim7nond 247 26 or or CC cord-282610-zim7nond 247 27 in in IN cord-282610-zim7nond 247 28 patients patient NNS cord-282610-zim7nond 247 29 with with IN cord-282610-zim7nond 247 30 related related JJ cord-282610-zim7nond 247 31 inflammatory inflammatory JJ cord-282610-zim7nond 247 32 conditions condition NNS cord-282610-zim7nond 247 33 . . . cord-282610-zim7nond 248 1 This this DT cord-282610-zim7nond 248 2 is be VBZ cord-282610-zim7nond 248 3 particularly particularly RB cord-282610-zim7nond 248 4 true true JJ cord-282610-zim7nond 248 5 of of IN cord-282610-zim7nond 248 6 studies study NNS cord-282610-zim7nond 248 7 that that WDT cord-282610-zim7nond 248 8 have have VBP cord-282610-zim7nond 248 9 searched search VBN cord-282610-zim7nond 248 10 for for IN cord-282610-zim7nond 248 11 EBV EBV NNP cord-282610-zim7nond 248 12 , , , cord-282610-zim7nond 248 13 HHV6 HHV6 NNP cord-282610-zim7nond 248 14 , , , cord-282610-zim7nond 248 15 Cytomegalovirus Cytomegalovirus NNP cord-282610-zim7nond 248 16 , , , cord-282610-zim7nond 248 17 and and CC cord-282610-zim7nond 248 18 other other JJ cord-282610-zim7nond 248 19 viruses virus NNS cord-282610-zim7nond 248 20 able able JJ cord-282610-zim7nond 248 21 to to TO cord-282610-zim7nond 248 22 be be VB cord-282610-zim7nond 248 23 identified identify VBN cord-282610-zim7nond 248 24 by by IN cord-282610-zim7nond 248 25 PCR PCR NNP cord-282610-zim7nond 248 26 and/or and/or CC cord-282610-zim7nond 248 27 antibody antibody NN cord-282610-zim7nond 248 28 testing testing NN cord-282610-zim7nond 248 29 in in IN cord-282610-zim7nond 248 30 ME ME NNP cord-282610-zim7nond 248 31 / / SYM cord-282610-zim7nond 248 32 CFS CFS NNP cord-282610-zim7nond 248 33 cohorts cohort NNS cord-282610-zim7nond 248 34 . . . cord-282610-zim7nond 249 1 This this DT cord-282610-zim7nond 249 2 same same JJ cord-282610-zim7nond 249 3 trend trend NN cord-282610-zim7nond 249 4 is be VBZ cord-282610-zim7nond 249 5 likely likely JJ cord-282610-zim7nond 249 6 to to TO cord-282610-zim7nond 249 7 hold hold VB cord-282610-zim7nond 249 8 for for IN cord-282610-zim7nond 249 9 lessstudied lessstudied JJ cord-282610-zim7nond 249 10 or or CC cord-282610-zim7nond 249 11 unidentified unidentified JJ cord-282610-zim7nond 249 12 human human JJ cord-282610-zim7nond 249 13 microbes microbe NNS cord-282610-zim7nond 249 14 and and CC cord-282610-zim7nond 249 15 viruses virus NNS cord-282610-zim7nond 249 16 . . . cord-282610-zim7nond 250 1 While while IN cord-282610-zim7nond 250 2 these these DT cord-282610-zim7nond 250 3 " " `` cord-282610-zim7nond 250 4 overlapping overlap VBG cord-282610-zim7nond 250 5 " " '' cord-282610-zim7nond 250 6 results result NNS cord-282610-zim7nond 250 7 are be VBP cord-282610-zim7nond 250 8 often often RB cord-282610-zim7nond 250 9 viewed view VBN cord-282610-zim7nond 250 10 as as IN cord-282610-zim7nond 250 11 problematic problematic JJ cord-282610-zim7nond 250 12 , , , cord-282610-zim7nond 250 13 they -PRON- PRP cord-282610-zim7nond 250 14 make make VBP cord-282610-zim7nond 250 15 sense sense NN cord-282610-zim7nond 250 16 in in IN cord-282610-zim7nond 250 17 light light NN cord-282610-zim7nond 250 18 of of IN cord-282610-zim7nond 250 19 research research NN cord-282610-zim7nond 250 20 that that WDT cord-282610-zim7nond 250 21 clarifies clarify VBZ cord-282610-zim7nond 250 22 how how WRB cord-282610-zim7nond 250 23 differently differently RB cord-282610-zim7nond 250 24 microbes microbe NNS cord-282610-zim7nond 250 25 act act VBP cord-282610-zim7nond 250 26 depending depend VBG cord-282610-zim7nond 250 27 on on IN cord-282610-zim7nond 250 28 host host NN cord-282610-zim7nond 250 29 immune immune JJ cord-282610-zim7nond 250 30 status status NN cord-282610-zim7nond 250 31 , , , cord-282610-zim7nond 250 32 neighboring neighboring NN cord-282610-zim7nond 250 33 species specie NNS cord-282610-zim7nond 250 34 , , , cord-282610-zim7nond 250 35 and and CC cord-282610-zim7nond 250 36 a a DT cord-282610-zim7nond 250 37 wide wide JJ cord-282610-zim7nond 250 38 range range NN cord-282610-zim7nond 250 39 of of IN cord-282610-zim7nond 250 40 other other JJ cord-282610-zim7nond 250 41 variables variable NNS cord-282610-zim7nond 250 42 . . . cord-282610-zim7nond 251 1 For for IN cord-282610-zim7nond 251 2 example example NN cord-282610-zim7nond 251 3 , , , cord-282610-zim7nond 251 4 susceptibility susceptibility NN cord-282610-zim7nond 251 5 to to IN cord-282610-zim7nond 251 6 HIV HIV NNP cord-282610-zim7nond 251 7 infection infection NN cord-282610-zim7nond 251 8 has have VBZ cord-282610-zim7nond 251 9 been be VBN cord-282610-zim7nond 251 10 shown show VBN cord-282610-zim7nond 251 11 to to TO cord-282610-zim7nond 251 12 vary vary VB cord-282610-zim7nond 251 13 based base VBN cord-282610-zim7nond 251 14 on on IN cord-282610-zim7nond 251 15 the the DT cord-282610-zim7nond 251 16 species specie NNS cord-282610-zim7nond 251 17 composition composition NN cord-282610-zim7nond 251 18 and and CC cord-282610-zim7nond 251 19 activity activity NN cord-282610-zim7nond 251 20 of of IN cord-282610-zim7nond 251 21 the the DT cord-282610-zim7nond 251 22 bacterial bacterial JJ cord-282610-zim7nond 251 23 vaginal vaginal JJ cord-282610-zim7nond 251 24 microbiome microbiome NN cord-282610-zim7nond 251 25 ( ( -LRB- cord-282610-zim7nond 251 26 97 97 CD cord-282610-zim7nond 251 27 ) ) -RRB- cord-282610-zim7nond 251 28 . . . cord-282610-zim7nond 252 1 Indeed indeed RB cord-282610-zim7nond 252 2 , , , cord-282610-zim7nond 252 3 most most JJS cord-282610-zim7nond 252 4 human human JJ cord-282610-zim7nond 252 5 microbes microbe NNS cord-282610-zim7nond 252 6 are be VBP cord-282610-zim7nond 252 7 pathobionts pathobiont NNS cord-282610-zim7nond 252 8 : : : cord-282610-zim7nond 252 9 they -PRON- PRP cord-282610-zim7nond 252 10 can can MD cord-282610-zim7nond 252 11 change change VB cord-282610-zim7nond 252 12 their -PRON- PRP$ cord-282610-zim7nond 252 13 gene gene NN cord-282610-zim7nond 252 14 expression expression NN cord-282610-zim7nond 252 15 to to TO cord-282610-zim7nond 252 16 act act VB cord-282610-zim7nond 252 17 as as IN cord-282610-zim7nond 252 18 pathogens pathogen NNS cord-282610-zim7nond 252 19 under under IN cord-282610-zim7nond 252 20 conditions condition NNS cord-282610-zim7nond 252 21 of of IN cord-282610-zim7nond 252 22 imbalance imbalance NN cord-282610-zim7nond 252 23 and and CC cord-282610-zim7nond 252 24 immunosuppression immunosuppression NN cord-282610-zim7nond 252 25 ( ( -LRB- cord-282610-zim7nond 252 26 98 98 CD cord-282610-zim7nond 252 27 ) ) -RRB- cord-282610-zim7nond 253 1 ( ( -LRB- cord-282610-zim7nond 253 2 99 99 CD cord-282610-zim7nond 253 3 ) ) -RRB- cord-282610-zim7nond 253 4 ( ( -LRB- cord-282610-zim7nond 253 5 100 100 CD cord-282610-zim7nond 253 6 ) ) -RRB- cord-282610-zim7nond 253 7 . . . cord-282610-zim7nond 254 1 For for IN cord-282610-zim7nond 254 2 example example NN cord-282610-zim7nond 254 3 , , , cord-282610-zim7nond 254 4 S. S. NNP cord-282610-zim7nond 254 5 pneumoniae pneumoniae NN cord-282610-zim7nond 254 6 can can MD cord-282610-zim7nond 254 7 persist persist VB cord-282610-zim7nond 254 8 as as IN cord-282610-zim7nond 254 9 a a DT cord-282610-zim7nond 254 10 highly highly RB cord-282610-zim7nond 254 11 adapted adapt VBN cord-282610-zim7nond 254 12 commensal commensal NN cord-282610-zim7nond 254 13 or or CC cord-282610-zim7nond 254 14 a a DT cord-282610-zim7nond 254 15 virulent virulent JJ cord-282610-zim7nond 254 16 pathogen pathogen NN cord-282610-zim7nond 254 17 depending depend VBG cord-282610-zim7nond 254 18 on on IN cord-282610-zim7nond 254 19 its -PRON- PRP$ cord-282610-zim7nond 254 20 ability ability NN cord-282610-zim7nond 254 21 to to TO cord-282610-zim7nond 254 22 evade evade VB cord-282610-zim7nond 254 23 the the DT cord-282610-zim7nond 254 24 host host NN cord-282610-zim7nond 254 25 immune immune JJ cord-282610-zim7nond 254 26 response response NN cord-282610-zim7nond 254 27 ( ( -LRB- cord-282610-zim7nond 254 28 101 101 CD cord-282610-zim7nond 254 29 ) ) -RRB- cord-282610-zim7nond 254 30 . . . cord-282610-zim7nond 255 1 S. S. NNP cord-282610-zim7nond 255 2 aureus aureus NN cord-282610-zim7nond 255 3 causes cause VBZ cord-282610-zim7nond 255 4 a a DT cord-282610-zim7nond 255 5 range range NN cord-282610-zim7nond 255 6 of of IN cord-282610-zim7nond 255 7 illnesses illness NNS cord-282610-zim7nond 255 8 , , , cord-282610-zim7nond 255 9 from from IN cord-282610-zim7nond 255 10 skin skin NN cord-282610-zim7nond 255 11 infections infection NNS cord-282610-zim7nond 255 12 to to IN cord-282610-zim7nond 255 13 life life NN cord-282610-zim7nond 255 14 - - HYPH cord-282610-zim7nond 255 15 threatening threaten VBG cord-282610-zim7nond 255 16 diseases disease NNS cord-282610-zim7nond 255 17 such such JJ cord-282610-zim7nond 255 18 as as IN cord-282610-zim7nond 255 19 endocarditis endocarditis NN cord-282610-zim7nond 255 20 and and CC cord-282610-zim7nond 255 21 meningitis meningitis NN cord-282610-zim7nond 255 22 . . . cord-282610-zim7nond 256 1 However however RB cord-282610-zim7nond 256 2 , , , cord-282610-zim7nond 256 3 ∼30 ∼30 NN cord-282610-zim7nond 256 4 % % NN cord-282610-zim7nond 256 5 of of IN cord-282610-zim7nond 256 6 the the DT cord-282610-zim7nond 256 7 healthy healthy JJ cord-282610-zim7nond 256 8 human human JJ cord-282610-zim7nond 256 9 population population NN cord-282610-zim7nond 256 10 harbors harbor VBZ cord-282610-zim7nond 256 11 S. S. NNP cord-282610-zim7nond 256 12 aureus aureus NN cord-282610-zim7nond 256 13 as as IN cord-282610-zim7nond 256 14 a a DT cord-282610-zim7nond 256 15 member member NN cord-282610-zim7nond 256 16 of of IN cord-282610-zim7nond 256 17 the the DT cord-282610-zim7nond 256 18 normal normal JJ cord-282610-zim7nond 256 19 nasal nasal NN cord-282610-zim7nond 256 20 microbiome microbiome NN cord-282610-zim7nond 256 21 ( ( -LRB- cord-282610-zim7nond 256 22 102 102 CD cord-282610-zim7nond 256 23 ) ) -RRB- cord-282610-zim7nond 256 24 . . . cord-282610-zim7nond 257 1 S. S. NNP cord-282610-zim7nond 257 2 aureus aureus NN cord-282610-zim7nond 257 3 virulence virulence NN cord-282610-zim7nond 257 4 in in IN cord-282610-zim7nond 257 5 these these DT cord-282610-zim7nond 257 6 communities community NNS cord-282610-zim7nond 257 7 is be VBZ cord-282610-zim7nond 257 8 determined determine VBN cord-282610-zim7nond 257 9 by by IN cord-282610-zim7nond 257 10 a a DT cord-282610-zim7nond 257 11 number number NN cord-282610-zim7nond 257 12 of of IN cord-282610-zim7nond 257 13 factors factor NNS cord-282610-zim7nond 257 14 , , , cord-282610-zim7nond 257 15 including include VBG cord-282610-zim7nond 257 16 the the DT cord-282610-zim7nond 257 17 signaling signal VBG cord-282610-zim7nond 257 18 and and CC cord-282610-zim7nond 257 19 competitive competitive JJ cord-282610-zim7nond 257 20 strategies strategy NNS cord-282610-zim7nond 257 21 employed employ VBN cord-282610-zim7nond 257 22 by by IN cord-282610-zim7nond 257 23 neighboring neighbor VBG cord-282610-zim7nond 257 24 microbes microbe NNS cord-282610-zim7nond 257 25 . . . cord-282610-zim7nond 258 1 The the DT cord-282610-zim7nond 258 2 same same JJ cord-282610-zim7nond 258 3 is be VBZ cord-282610-zim7nond 258 4 true true JJ cord-282610-zim7nond 258 5 of of IN cord-282610-zim7nond 258 6 Escherichia Escherichia NNP cord-282610-zim7nond 258 7 coli coli NNS cord-282610-zim7nond 258 8 ( ( -LRB- cord-282610-zim7nond 258 9 E. E. NNP cord-282610-zim7nond 258 10 coli coli NNS cord-282610-zim7nond 258 11 ) ) -RRB- cord-282610-zim7nond 258 12 , , , cord-282610-zim7nond 258 13 which which WDT cord-282610-zim7nond 258 14 also also RB cord-282610-zim7nond 258 15 persists persist VBZ cord-282610-zim7nond 258 16 in in IN cord-282610-zim7nond 258 17 numerous numerous JJ cord-282610-zim7nond 258 18 forms form NNS cord-282610-zim7nond 258 19 . . . cord-282610-zim7nond 259 1 One one CD cord-282610-zim7nond 259 2 study study NN cord-282610-zim7nond 259 3 found find VBD cord-282610-zim7nond 259 4 that that IN cord-282610-zim7nond 259 5 " " `` cord-282610-zim7nond 259 6 commensal commensal JJ cord-282610-zim7nond 259 7 " " '' cord-282610-zim7nond 259 8 E. E. NNP cord-282610-zim7nond 259 9 coli coli NNS cord-282610-zim7nond 259 10 could could MD cord-282610-zim7nond 259 11 evolve evolve VB cord-282610-zim7nond 259 12 into into IN cord-282610-zim7nond 259 13 virulent virulent JJ cord-282610-zim7nond 259 14 clones clone NNS cord-282610-zim7nond 259 15 in in IN cord-282610-zim7nond 259 16 fewer few JJR cord-282610-zim7nond 259 17 than than IN cord-282610-zim7nond 259 18 500 500 CD cord-282610-zim7nond 259 19 generations generation NNS cord-282610-zim7nond 259 20 ( ( -LRB- cord-282610-zim7nond 259 21 103 103 CD cord-282610-zim7nond 259 22 ) ) -RRB- cord-282610-zim7nond 259 23 . . . cord-282610-zim7nond 260 1 For for IN cord-282610-zim7nond 260 2 most most JJS cord-282610-zim7nond 260 3 microbes microbe NNS cord-282610-zim7nond 260 4 , , , cord-282610-zim7nond 260 5 this this DT cord-282610-zim7nond 260 6 evolution evolution NN cord-282610-zim7nond 260 7 toward toward IN cord-282610-zim7nond 260 8 pathogenicity pathogenicity NN cord-282610-zim7nond 260 9 occurs occur VBZ cord-282610-zim7nond 260 10 via via IN cord-282610-zim7nond 260 11 the the DT cord-282610-zim7nond 260 12 acquisition acquisition NN cord-282610-zim7nond 260 13 of of IN cord-282610-zim7nond 260 14 new new JJ cord-282610-zim7nond 260 15 genes gene NNS cord-282610-zim7nond 260 16 or or CC cord-282610-zim7nond 260 17 alteration alteration NN cord-282610-zim7nond 260 18 of of IN cord-282610-zim7nond 260 19 the the DT cord-282610-zim7nond 260 20 current current JJ cord-282610-zim7nond 260 21 genome genome NN cord-282610-zim7nond 260 22 in in IN cord-282610-zim7nond 260 23 a a DT cord-282610-zim7nond 260 24 manner manner NN cord-282610-zim7nond 260 25 that that WDT cord-282610-zim7nond 260 26 induces induce VBZ cord-282610-zim7nond 260 27 gene gene NN cord-282610-zim7nond 260 28 loss loss NN cord-282610-zim7nond 260 29 ( ( -LRB- cord-282610-zim7nond 260 30 104 104 CD cord-282610-zim7nond 260 31 ) ) -RRB- cord-282610-zim7nond 260 32 . . . cord-282610-zim7nond 261 1 For for IN cord-282610-zim7nond 261 2 example example NN cord-282610-zim7nond 261 3 , , , cord-282610-zim7nond 261 4 loss loss NN cord-282610-zim7nond 261 5 of of IN cord-282610-zim7nond 261 6 mucA muca NN cord-282610-zim7nond 261 7 increases increase VBZ cord-282610-zim7nond 261 8 the the DT cord-282610-zim7nond 261 9 ability ability NN cord-282610-zim7nond 261 10 of of IN cord-282610-zim7nond 261 11 Pseudomonas Pseudomonas NNP cord-282610-zim7nond 261 12 aeruginosa aeruginosa VBZ cord-282610-zim7nond 261 13 to to TO cord-282610-zim7nond 261 14 evade evade VB cord-282610-zim7nond 261 15 phagocytosis phagocytosis NN cord-282610-zim7nond 261 16 and and CC cord-282610-zim7nond 261 17 resist resist VB cord-282610-zim7nond 261 18 pulmonary pulmonary JJ cord-282610-zim7nond 261 19 clearance clearance NN cord-282610-zim7nond 261 20 ( ( -LRB- cord-282610-zim7nond 261 21 105 105 CD cord-282610-zim7nond 261 22 ) ) -RRB- cord-282610-zim7nond 261 23 . . . cord-282610-zim7nond 262 1 It -PRON- PRP cord-282610-zim7nond 262 2 should should MD cord-282610-zim7nond 262 3 also also RB cord-282610-zim7nond 262 4 be be VB cord-282610-zim7nond 262 5 noted note VBN cord-282610-zim7nond 262 6 that that IN cord-282610-zim7nond 262 7 every every DT cord-282610-zim7nond 262 8 microbial microbial JJ cord-282610-zim7nond 262 9 species species NN cord-282610-zim7nond 262 10 represents represent VBZ cord-282610-zim7nond 262 11 many many JJ cord-282610-zim7nond 262 12 different different JJ cord-282610-zim7nond 262 13 strains strain NNS cord-282610-zim7nond 262 14 , , , cord-282610-zim7nond 262 15 each each DT cord-282610-zim7nond 262 16 of of IN cord-282610-zim7nond 262 17 which which WDT cord-282610-zim7nond 262 18 may may MD cord-282610-zim7nond 262 19 vary vary VB cord-282610-zim7nond 262 20 in in IN cord-282610-zim7nond 262 21 the the DT cord-282610-zim7nond 262 22 set set NN cord-282610-zim7nond 262 23 of of IN cord-282610-zim7nond 262 24 genes gene NNS cord-282610-zim7nond 262 25 it -PRON- PRP cord-282610-zim7nond 262 26 encodes encode VBZ cord-282610-zim7nond 262 27 or or CC cord-282610-zim7nond 262 28 in in IN cord-282610-zim7nond 262 29 the the DT cord-282610-zim7nond 262 30 copy copy NN cord-282610-zim7nond 262 31 number number NN cord-282610-zim7nond 262 32 of of IN cord-282610-zim7nond 262 33 such such JJ cord-282610-zim7nond 262 34 genes gene NNS cord-282610-zim7nond 262 35 . . . cord-282610-zim7nond 263 1 This this DT cord-282610-zim7nond 263 2 intra intra JJ cord-282610-zim7nond 263 3 - - JJ cord-282610-zim7nond 263 4 species species JJ cord-282610-zim7nond 263 5 variation variation NN cord-282610-zim7nond 263 6 endows endow VBZ cord-282610-zim7nond 263 7 each each DT cord-282610-zim7nond 263 8 strain strain NN cord-282610-zim7nond 263 9 with with IN cord-282610-zim7nond 263 10 distinct distinct JJ cord-282610-zim7nond 263 11 functional functional JJ cord-282610-zim7nond 263 12 capacities capacity NNS cord-282610-zim7nond 263 13 , , , cord-282610-zim7nond 263 14 including include VBG cord-282610-zim7nond 263 15 differences difference NNS cord-282610-zim7nond 263 16 in in IN cord-282610-zim7nond 263 17 virulence virulence NN cord-282610-zim7nond 263 18 , , , cord-282610-zim7nond 263 19 motility motility NN cord-282610-zim7nond 263 20 , , , cord-282610-zim7nond 263 21 nutrient nutrient NN cord-282610-zim7nond 263 22 utilization utilization NN cord-282610-zim7nond 263 23 , , , cord-282610-zim7nond 263 24 and and CC cord-282610-zim7nond 263 25 drug drug NN cord-282610-zim7nond 263 26 resistance resistance NN cord-282610-zim7nond 263 27 ( ( -LRB- cord-282610-zim7nond 263 28 106 106 CD cord-282610-zim7nond 263 29 ) ) -RRB- cord-282610-zim7nond 263 30 . . . cord-282610-zim7nond 264 1 Greenblum Greenblum NNP cord-282610-zim7nond 264 2 et et FW cord-282610-zim7nond 264 3 al al NNP cord-282610-zim7nond 264 4 . . . cord-282610-zim7nond 265 1 ( ( -LRB- cord-282610-zim7nond 265 2 106 106 CD cord-282610-zim7nond 265 3 ) ) -RRB- cord-282610-zim7nond 265 4 identified identify VBD cord-282610-zim7nond 265 5 extensive extensive JJ cord-282610-zim7nond 265 6 strainlevel strainlevel NN cord-282610-zim7nond 265 7 copy copy NN cord-282610-zim7nond 265 8 - - HYPH cord-282610-zim7nond 265 9 number number NN cord-282610-zim7nond 265 10 variation variation NN cord-282610-zim7nond 265 11 across across IN cord-282610-zim7nond 265 12 species specie NNS cord-282610-zim7nond 265 13 in in IN cord-282610-zim7nond 265 14 metagenomic metagenomic JJ cord-282610-zim7nond 265 15 samples sample NNS cord-282610-zim7nond 265 16 obtained obtain VBN cord-282610-zim7nond 265 17 from from IN cord-282610-zim7nond 265 18 patients patient NNS cord-282610-zim7nond 265 19 with with IN cord-282610-zim7nond 265 20 irritable irritable JJ cord-282610-zim7nond 265 21 bowel bowel NN cord-282610-zim7nond 265 22 syndrome syndrome NN cord-282610-zim7nond 265 23 . . . cord-282610-zim7nond 266 1 This this DT cord-282610-zim7nond 266 2 was be VBD cord-282610-zim7nond 266 3 especially especially RB cord-282610-zim7nond 266 4 true true JJ cord-282610-zim7nond 266 5 of of IN cord-282610-zim7nond 266 6 genes gene NNS cord-282610-zim7nond 266 7 tied tie VBN cord-282610-zim7nond 266 8 to to IN cord-282610-zim7nond 266 9 specific specific JJ cord-282610-zim7nond 266 10 community community NN cord-282610-zim7nond 266 11 functions function NNS cord-282610-zim7nond 266 12 , , , cord-282610-zim7nond 266 13 including include VBG cord-282610-zim7nond 266 14 functions function NNS cord-282610-zim7nond 266 15 related relate VBN cord-282610-zim7nond 266 16 to to IN cord-282610-zim7nond 266 17 community community NN cord-282610-zim7nond 266 18 lifestyle lifestyle NN cord-282610-zim7nond 266 19 . . . cord-282610-zim7nond 267 1 Differences difference NNS cord-282610-zim7nond 267 2 in in IN cord-282610-zim7nond 267 3 gene gene NN cord-282610-zim7nond 267 4 copy copy NN cord-282610-zim7nond 267 5 - - HYPH cord-282610-zim7nond 267 6 number number NN cord-282610-zim7nond 267 7 also also RB cord-282610-zim7nond 267 8 impacted impact VBN cord-282610-zim7nond 267 9 adaptive adaptive JJ cord-282610-zim7nond 267 10 functions function NNS cord-282610-zim7nond 267 11 linked link VBN cord-282610-zim7nond 267 12 to to IN cord-282610-zim7nond 267 13 obesity obesity NN cord-282610-zim7nond 267 14 . . . cord-282610-zim7nond 268 1 Yao Yao NNP cord-282610-zim7nond 268 2 et et NNP cord-282610-zim7nond 268 3 al al NNP cord-282610-zim7nond 268 4 . . . cord-282610-zim7nond 269 1 ( ( -LRB- cord-282610-zim7nond 269 2 107 107 CD cord-282610-zim7nond 269 3 ) ) -RRB- cord-282610-zim7nond 269 4 found find VBD cord-282610-zim7nond 269 5 that that IN cord-282610-zim7nond 269 6 deletion deletion NN cord-282610-zim7nond 269 7 of of IN cord-282610-zim7nond 269 8 a a DT cord-282610-zim7nond 269 9 single single JJ cord-282610-zim7nond 269 10 Bacteriodes Bacteriodes NNP cord-282610-zim7nond 269 11 gene gene NN cord-282610-zim7nond 269 12 - - : cord-282610-zim7nond 269 13 and and CC cord-282610-zim7nond 269 14 the the DT cord-282610-zim7nond 269 15 bile bile NN cord-282610-zim7nond 269 16 salt salt NN cord-282610-zim7nond 269 17 hydrolase hydrolase NN cord-282610-zim7nond 269 18 it -PRON- PRP cord-282610-zim7nond 269 19 expresses express VBZ cord-282610-zim7nond 269 20 - - HYPH cord-282610-zim7nond 269 21 altered alter VBN cord-282610-zim7nond 269 22 host host NN cord-282610-zim7nond 269 23 metabolism metabolism NN cord-282610-zim7nond 269 24 in in IN cord-282610-zim7nond 269 25 a a DT cord-282610-zim7nond 269 26 manner manner NN cord-282610-zim7nond 269 27 that that WDT cord-282610-zim7nond 269 28 impacted impact VBD cord-282610-zim7nond 269 29 weight weight NN cord-282610-zim7nond 269 30 management management NN cord-282610-zim7nond 269 31 , , , cord-282610-zim7nond 269 32 circadian circadian JJ cord-282610-zim7nond 269 33 rhythm rhythm NN cord-282610-zim7nond 269 34 and and CC cord-282610-zim7nond 269 35 immunity immunity NN cord-282610-zim7nond 269 36 . . . cord-282610-zim7nond 270 1 A a DT cord-282610-zim7nond 270 2 microbe microbe NN cord-282610-zim7nond 270 3 or or CC cord-282610-zim7nond 270 4 a a DT cord-282610-zim7nond 270 5 virus virus NN cord-282610-zim7nond 270 6 ' ' '' cord-282610-zim7nond 270 7 location location NN cord-282610-zim7nond 270 8 can can MD cord-282610-zim7nond 270 9 also also RB cord-282610-zim7nond 270 10 influence influence VB cord-282610-zim7nond 270 11 its -PRON- PRP$ cord-282610-zim7nond 270 12 activity activity NN cord-282610-zim7nond 270 13 . . . cord-282610-zim7nond 271 1 For for IN cord-282610-zim7nond 271 2 example example NN cord-282610-zim7nond 271 3 , , , cord-282610-zim7nond 271 4 much much JJ cord-282610-zim7nond 271 5 of of IN cord-282610-zim7nond 271 6 the the DT cord-282610-zim7nond 271 7 human human JJ cord-282610-zim7nond 271 8 population population NN cord-282610-zim7nond 271 9 harbors harbor VBZ cord-282610-zim7nond 271 10 HHV-6 HHV-6 NNP cord-282610-zim7nond 271 11 . . . cord-282610-zim7nond 272 1 However however RB cord-282610-zim7nond 272 2 , , , cord-282610-zim7nond 272 3 in in IN cord-282610-zim7nond 272 4 Alzheimer Alzheimer NNP cord-282610-zim7nond 272 5 's 's POS cord-282610-zim7nond 272 6 disease disease NN cord-282610-zim7nond 272 7 , , , cord-282610-zim7nond 272 8 HHV-6A HHV-6A NNP cord-282610-zim7nond 272 9 was be VBD cord-282610-zim7nond 272 10 recently recently RB cord-282610-zim7nond 272 11 identified identify VBN cord-282610-zim7nond 272 12 in in IN cord-282610-zim7nond 272 13 human human JJ cord-282610-zim7nond 272 14 brain brain NN cord-282610-zim7nond 272 15 tissue tissue NN cord-282610-zim7nond 272 16 ( ( -LRB- cord-282610-zim7nond 272 17 88 88 CD cord-282610-zim7nond 272 18 ) ) -RRB- cord-282610-zim7nond 272 19 . . . cord-282610-zim7nond 273 1 There there RB cord-282610-zim7nond 273 2 , , , cord-282610-zim7nond 273 3 its -PRON- PRP$ cord-282610-zim7nond 273 4 activity activity NN cord-282610-zim7nond 273 5 was be VBD cord-282610-zim7nond 273 6 shown show VBN cord-282610-zim7nond 273 7 capable capable JJ cord-282610-zim7nond 273 8 of of IN cord-282610-zim7nond 273 9 regulating regulate VBG cord-282610-zim7nond 273 10 host host NN cord-282610-zim7nond 273 11 molecular molecular JJ cord-282610-zim7nond 273 12 , , , cord-282610-zim7nond 273 13 clinical clinical JJ cord-282610-zim7nond 273 14 , , , cord-282610-zim7nond 273 15 and and CC cord-282610-zim7nond 273 16 neuropathological neuropathological JJ cord-282610-zim7nond 273 17 networks network NNS cord-282610-zim7nond 273 18 in in IN cord-282610-zim7nond 273 19 a a DT cord-282610-zim7nond 273 20 manner manner NN cord-282610-zim7nond 273 21 that that WDT cord-282610-zim7nond 273 22 can can MD cord-282610-zim7nond 273 23 contribute contribute VB cord-282610-zim7nond 273 24 to to IN cord-282610-zim7nond 273 25 inflammation inflammation NN cord-282610-zim7nond 273 26 and and CC cord-282610-zim7nond 273 27 neuronal neuronal JJ cord-282610-zim7nond 273 28 loss loss NN cord-282610-zim7nond 273 29 . . . cord-282610-zim7nond 274 1 VanElzakker VanElzakker NNP cord-282610-zim7nond 274 2 ( ( -LRB- cord-282610-zim7nond 274 3 108 108 CD cord-282610-zim7nond 274 4 ) ) -RRB- cord-282610-zim7nond 274 5 has have VBZ cord-282610-zim7nond 274 6 proposed propose VBN cord-282610-zim7nond 274 7 that that IN cord-282610-zim7nond 274 8 HHV-6 HHV-6 NNP cord-282610-zim7nond 274 9 may may MD cord-282610-zim7nond 274 10 also also RB cord-282610-zim7nond 274 11 infect infect VB cord-282610-zim7nond 274 12 the the DT cord-282610-zim7nond 274 13 vagus vagus NN cord-282610-zim7nond 274 14 nerve nerve NN cord-282610-zim7nond 274 15 in in IN cord-282610-zim7nond 274 16 ME ME NNP cord-282610-zim7nond 274 17 / / SYM cord-282610-zim7nond 274 18 CFS CFS NNP cord-282610-zim7nond 274 19 , , , cord-282610-zim7nond 274 20 resulting result VBG cord-282610-zim7nond 274 21 in in IN cord-282610-zim7nond 274 22 altered alter VBN cord-282610-zim7nond 274 23 gutbrain gutbrain NN cord-282610-zim7nond 274 24 axis axis NN cord-282610-zim7nond 274 25 signaling signal VBG cord-282610-zim7nond 274 26 in in IN cord-282610-zim7nond 274 27 patients patient NNS cord-282610-zim7nond 274 28 with with IN cord-282610-zim7nond 274 29 the the DT cord-282610-zim7nond 274 30 illness illness NN cord-282610-zim7nond 274 31 . . . cord-282610-zim7nond 275 1 The the DT cord-282610-zim7nond 275 2 human human JJ cord-282610-zim7nond 275 3 immune immune NN cord-282610-zim7nond 275 4 system system NN cord-282610-zim7nond 275 5 also also RB cord-282610-zim7nond 275 6 plays play VBZ cord-282610-zim7nond 275 7 a a DT cord-282610-zim7nond 275 8 central central JJ cord-282610-zim7nond 275 9 role role NN cord-282610-zim7nond 275 10 in in IN cord-282610-zim7nond 275 11 determining determine VBG cord-282610-zim7nond 275 12 microbe microbe NN cord-282610-zim7nond 275 13 and and CC cord-282610-zim7nond 275 14 viral viral JJ cord-282610-zim7nond 275 15 activity activity NN cord-282610-zim7nond 275 16 . . . cord-282610-zim7nond 276 1 A a DT cord-282610-zim7nond 276 2 robust robust JJ cord-282610-zim7nond 276 3 immune immune JJ cord-282610-zim7nond 276 4 response response NN cord-282610-zim7nond 276 5 is be VBZ cord-282610-zim7nond 276 6 often often RB cord-282610-zim7nond 276 7 capable capable JJ cord-282610-zim7nond 276 8 of of IN cord-282610-zim7nond 276 9 controlling control VBG cord-282610-zim7nond 276 10 pathogen pathogen NN cord-282610-zim7nond 276 11 virulence virulence NN cord-282610-zim7nond 276 12 . . . cord-282610-zim7nond 277 1 However however RB cord-282610-zim7nond 277 2 , , , cord-282610-zim7nond 277 3 if if IN cord-282610-zim7nond 277 4 pathogens pathogen NNS cord-282610-zim7nond 277 5 overcome overcome VBP cord-282610-zim7nond 277 6 the the DT cord-282610-zim7nond 277 7 immune immune JJ cord-282610-zim7nond 277 8 response response NN cord-282610-zim7nond 277 9 , , , cord-282610-zim7nond 277 10 or or CC cord-282610-zim7nond 277 11 the the DT cord-282610-zim7nond 277 12 immune immune JJ cord-282610-zim7nond 277 13 system system NN cord-282610-zim7nond 277 14 is be VBZ cord-282610-zim7nond 277 15 suppressed suppress VBN cord-282610-zim7nond 277 16 by by IN cord-282610-zim7nond 277 17 medications medication NNS cord-282610-zim7nond 277 18 , , , cord-282610-zim7nond 277 19 chemicals chemical NNS cord-282610-zim7nond 277 20 , , , cord-282610-zim7nond 277 21 or or CC cord-282610-zim7nond 277 22 other other JJ cord-282610-zim7nond 277 23 environmental environmental JJ cord-282610-zim7nond 277 24 factors factor NNS cord-282610-zim7nond 277 25 , , , cord-282610-zim7nond 277 26 pathobionts pathobiont NNS cord-282610-zim7nond 277 27 are be VBP cord-282610-zim7nond 277 28 more more RBR cord-282610-zim7nond 277 29 likely likely JJ cord-282610-zim7nond 277 30 to to TO cord-282610-zim7nond 277 31 alter alter VB cord-282610-zim7nond 277 32 their -PRON- PRP$ cord-282610-zim7nond 277 33 gene gene NN cord-282610-zim7nond 277 34 expression expression NN cord-282610-zim7nond 277 35 in in IN cord-282610-zim7nond 277 36 a a DT cord-282610-zim7nond 277 37 manner manner NN cord-282610-zim7nond 277 38 that that WDT cord-282610-zim7nond 277 39 promotes promote VBZ cord-282610-zim7nond 277 40 disease disease NN cord-282610-zim7nond 277 41 . . . cord-282610-zim7nond 278 1 Pathobionts pathobiont NNS cord-282610-zim7nond 278 2 can can MD cord-282610-zim7nond 278 3 subvert subvert VB cord-282610-zim7nond 278 4 the the DT cord-282610-zim7nond 278 5 human human JJ cord-282610-zim7nond 278 6 immune immune JJ cord-282610-zim7nond 278 7 response response NN cord-282610-zim7nond 278 8 by by IN cord-282610-zim7nond 278 9 collectively collectively RB cord-282610-zim7nond 278 10 altering alter VBG cord-282610-zim7nond 278 11 their -PRON- PRP$ cord-282610-zim7nond 278 12 gene gene NN cord-282610-zim7nond 278 13 expression expression NN cord-282610-zim7nond 278 14 . . . cord-282610-zim7nond 279 1 Yost Yost NNP cord-282610-zim7nond 279 2 et et NNP cord-282610-zim7nond 279 3 al al NNP cord-282610-zim7nond 279 4 . . . cord-282610-zim7nond 280 1 ( ( -LRB- cord-282610-zim7nond 280 2 100 100 CD cord-282610-zim7nond 280 3 ) ) -RRB- cord-282610-zim7nond 280 4 performed perform VBD cord-282610-zim7nond 280 5 an an DT cord-282610-zim7nond 280 6 excellent excellent JJ cord-282610-zim7nond 280 7 gene gene NN cord-282610-zim7nond 280 8 ontology ontology NN cord-282610-zim7nond 280 9 ( ( -LRB- cord-282610-zim7nond 280 10 GO GO NNP cord-282610-zim7nond 280 11 ) ) -RRB- cord-282610-zim7nond 280 12 enrichment enrichment NN cord-282610-zim7nond 280 13 analysis analysis NN cord-282610-zim7nond 280 14 of of IN cord-282610-zim7nond 280 15 the the DT cord-282610-zim7nond 280 16 oral oral JJ cord-282610-zim7nond 280 17 microbiome microbiome NN cord-282610-zim7nond 280 18 during during IN cord-282610-zim7nond 280 19 periodontal periodontal JJ cord-282610-zim7nond 280 20 progression progression NN cord-282610-zim7nond 280 21 . . . cord-282610-zim7nond 281 1 Over over IN cord-282610-zim7nond 281 2 the the DT cord-282610-zim7nond 281 3 two two CD cord-282610-zim7nond 281 4 - - HYPH cord-282610-zim7nond 281 5 month month NN cord-282610-zim7nond 281 6 study study NN cord-282610-zim7nond 281 7 period period NN cord-282610-zim7nond 281 8 , , , cord-282610-zim7nond 281 9 changes change NNS cord-282610-zim7nond 281 10 in in IN cord-282610-zim7nond 281 11 the the DT cord-282610-zim7nond 281 12 metagenome metagenome NN cord-282610-zim7nond 281 13 of of IN cord-282610-zim7nond 281 14 non non JJ cord-282610-zim7nond 281 15 - - JJ cord-282610-zim7nond 281 16 progressing progressing JJ cord-282610-zim7nond 281 17 sites site NNS cord-282610-zim7nond 281 18 were be VBD cord-282610-zim7nond 281 19 minor minor JJ cord-282610-zim7nond 281 20 . . . cord-282610-zim7nond 282 1 However however RB cord-282610-zim7nond 282 2 , , , cord-282610-zim7nond 282 3 active active JJ cord-282610-zim7nond 282 4 sites site NNS cord-282610-zim7nond 282 5 that that WDT cord-282610-zim7nond 282 6 progressed progress VBD cord-282610-zim7nond 282 7 to to IN cord-282610-zim7nond 282 8 periodontitis periodontitis NN cord-282610-zim7nond 282 9 were be VBD cord-282610-zim7nond 282 10 characterized characterize VBN cord-282610-zim7nond 282 11 by by IN cord-282610-zim7nond 282 12 numerous numerous JJ cord-282610-zim7nond 282 13 functional functional JJ cord-282610-zim7nond 282 14 genomic genomic JJ cord-282610-zim7nond 282 15 signatures signature NNS cord-282610-zim7nond 282 16 . . . cord-282610-zim7nond 283 1 In in IN cord-282610-zim7nond 283 2 fact fact NN cord-282610-zim7nond 283 3 , , , cord-282610-zim7nond 283 4 the the DT cord-282610-zim7nond 283 5 team team NN cord-282610-zim7nond 283 6 reported report VBD cord-282610-zim7nond 283 7 a a DT cord-282610-zim7nond 283 8 complete complete JJ cord-282610-zim7nond 283 9 rearrangement rearrangement NN cord-282610-zim7nond 283 10 at at IN cord-282610-zim7nond 283 11 the the DT cord-282610-zim7nond 283 12 metagenome metagenome NN cord-282610-zim7nond 283 13 level level NN cord-282610-zim7nond 283 14 between between IN cord-282610-zim7nond 283 15 baseline baseline JJ cord-282610-zim7nond 283 16 sites site NNS cord-282610-zim7nond 283 17 that that WDT cord-282610-zim7nond 283 18 progressed progress VBD cord-282610-zim7nond 283 19 to to IN cord-282610-zim7nond 283 20 periodontitis periodontitis NN cord-282610-zim7nond 283 21 and and CC cord-282610-zim7nond 283 22 those those DT cord-282610-zim7nond 283 23 that that WDT cord-282610-zim7nond 283 24 did do VBD cord-282610-zim7nond 283 25 not not RB cord-282610-zim7nond 283 26 . . . cord-282610-zim7nond 284 1 GO go VB cord-282610-zim7nond 284 2 terms term NNS cord-282610-zim7nond 284 3 associated associate VBN cord-282610-zim7nond 284 4 with with IN cord-282610-zim7nond 284 5 processes process NNS cord-282610-zim7nond 284 6 including include VBG cord-282610-zim7nond 284 7 peptidoglycan peptidoglycan JJ cord-282610-zim7nond 284 8 biosynthesis biosynthesis NN cord-282610-zim7nond 284 9 and and CC cord-282610-zim7nond 284 10 potassium potassium NN cord-282610-zim7nond 284 11 transport transport NN cord-282610-zim7nond 284 12 were be VBD cord-282610-zim7nond 284 13 highly highly RB cord-282610-zim7nond 284 14 enriched enrich VBN cord-282610-zim7nond 284 15 at at IN cord-282610-zim7nond 284 16 baseline baseline JJ cord-282610-zim7nond 284 17 sites site NNS cord-282610-zim7nond 284 18 that that WDT cord-282610-zim7nond 284 19 later later RB cord-282610-zim7nond 284 20 progressed progress VBD cord-282610-zim7nond 284 21 to to IN cord-282610-zim7nond 284 22 periodontitis periodontitis NN cord-282610-zim7nond 284 23 . . . cord-282610-zim7nond 285 1 Genes gene NNS cord-282610-zim7nond 285 2 controlling control VBG cord-282610-zim7nond 285 3 ciliary ciliary NN cord-282610-zim7nond 285 4 motility motility NN cord-282610-zim7nond 285 5 and and CC cord-282610-zim7nond 285 6 CRISPR CRISPR NNP cord-282610-zim7nond 285 7 - - HYPH cord-282610-zim7nond 285 8 associated associate VBN cord-282610-zim7nond 285 9 proteins protein NNS cord-282610-zim7nond 285 10 were be VBD cord-282610-zim7nond 285 11 also also RB cord-282610-zim7nond 285 12 active active JJ cord-282610-zim7nond 285 13 during during IN cord-282610-zim7nond 285 14 initial initial JJ cord-282610-zim7nond 285 15 stages stage NNS cord-282610-zim7nond 285 16 of of IN cord-282610-zim7nond 285 17 disease disease NN cord-282610-zim7nond 285 18 progression progression NN cord-282610-zim7nond 285 19 . . . cord-282610-zim7nond 286 1 At at IN cord-282610-zim7nond 286 2 the the DT cord-282610-zim7nond 286 3 breakdown breakdown NN cord-282610-zim7nond 286 4 point point NN cord-282610-zim7nond 286 5 , , , cord-282610-zim7nond 286 6 active active JJ cord-282610-zim7nond 286 7 sites site NNS cord-282610-zim7nond 286 8 expressed express VBD cord-282610-zim7nond 286 9 genes gene NNS cord-282610-zim7nond 286 10 associated associate VBN cord-282610-zim7nond 286 11 with with IN cord-282610-zim7nond 286 12 ferrous ferrous JJ cord-282610-zim7nond 286 13 iron iron NN cord-282610-zim7nond 286 14 transport transport NN cord-282610-zim7nond 286 15 and and CC cord-282610-zim7nond 286 16 response response NN cord-282610-zim7nond 286 17 to to IN cord-282610-zim7nond 286 18 oxidative oxidative JJ cord-282610-zim7nond 286 19 stress stress NN cord-282610-zim7nond 286 20 . . . cord-282610-zim7nond 287 1 Progression progression NN cord-282610-zim7nond 287 2 to to IN cord-282610-zim7nond 287 3 periodontitis periodontitis NN cord-282610-zim7nond 287 4 was be VBD cord-282610-zim7nond 287 5 also also RB cord-282610-zim7nond 287 6 correlated correlate VBN cord-282610-zim7nond 287 7 with with IN cord-282610-zim7nond 287 8 increased increase VBN cord-282610-zim7nond 287 9 expression expression NN cord-282610-zim7nond 287 10 of of IN cord-282610-zim7nond 287 11 putative putative JJ cord-282610-zim7nond 287 12 virulence virulence NN cord-282610-zim7nond 287 13 factors factor NNS cord-282610-zim7nond 287 14 associated associate VBN cord-282610-zim7nond 287 15 with with IN cord-282610-zim7nond 287 16 a a DT cord-282610-zim7nond 287 17 range range NN cord-282610-zim7nond 287 18 of of IN cord-282610-zim7nond 287 19 bacterial bacterial JJ cord-282610-zim7nond 287 20 species specie NNS cord-282610-zim7nond 287 21 . . . cord-282610-zim7nond 288 1 Mycoplasma mycoplasma NN cord-282610-zim7nond 288 2 , , , cord-282610-zim7nond 288 3 bacteriophage bacteriophage NN cord-282610-zim7nond 288 4 , , , cord-282610-zim7nond 288 5 and and CC cord-282610-zim7nond 288 6 eukaryotic eukaryotic JJ cord-282610-zim7nond 288 7 viral viral JJ cord-282610-zim7nond 288 8 activity activity NN cord-282610-zim7nond 288 9 were be VBD cord-282610-zim7nond 288 10 higher high JJR cord-282610-zim7nond 288 11 in in IN cord-282610-zim7nond 288 12 progressing progress VBG cord-282610-zim7nond 288 13 sites site NNS cord-282610-zim7nond 288 14 compared compare VBN cord-282610-zim7nond 288 15 to to IN cord-282610-zim7nond 288 16 baseline baseline JJ cord-282610-zim7nond 288 17 samples sample NNS cord-282610-zim7nond 288 18 . . . cord-282610-zim7nond 289 1 The the DT cord-282610-zim7nond 289 2 team team NN cord-282610-zim7nond 289 3 concluded conclude VBD cord-282610-zim7nond 289 4 that that IN cord-282610-zim7nond 289 5 periodontitis periodontitis NN cord-282610-zim7nond 289 6 progression progression NN cord-282610-zim7nond 289 7 is be VBZ cord-282610-zim7nond 289 8 driven drive VBN cord-282610-zim7nond 289 9 by by IN cord-282610-zim7nond 289 10 the the DT cord-282610-zim7nond 289 11 whole whole JJ cord-282610-zim7nond 289 12 oral oral JJ cord-282610-zim7nond 289 13 microbial microbial JJ cord-282610-zim7nond 289 14 community community NN cord-282610-zim7nond 289 15 and and CC cord-282610-zim7nond 289 16 not not RB cord-282610-zim7nond 289 17 just just RB cord-282610-zim7nond 289 18 a a DT cord-282610-zim7nond 289 19 few few JJ cord-282610-zim7nond 289 20 select select JJ cord-282610-zim7nond 289 21 pathogens pathogen NNS cord-282610-zim7nond 289 22 . . . cord-282610-zim7nond 290 1 In in IN cord-282610-zim7nond 290 2 effect effect NN cord-282610-zim7nond 290 3 , , , cord-282610-zim7nond 290 4 under under IN cord-282610-zim7nond 290 5 conditions condition NNS cord-282610-zim7nond 290 6 of of IN cord-282610-zim7nond 290 7 increasing increase VBG cord-282610-zim7nond 290 8 inflammation inflammation NN cord-282610-zim7nond 290 9 and and CC cord-282610-zim7nond 290 10 imbalance imbalance NN cord-282610-zim7nond 290 11 , , , cord-282610-zim7nond 290 12 the the DT cord-282610-zim7nond 290 13 entire entire JJ cord-282610-zim7nond 290 14 oral oral JJ cord-282610-zim7nond 290 15 community community NN cord-282610-zim7nond 290 16 appeared appear VBD cord-282610-zim7nond 290 17 to to TO cord-282610-zim7nond 290 18 act act VB cord-282610-zim7nond 290 19 together together RB cord-282610-zim7nond 290 20 as as IN cord-282610-zim7nond 290 21 a a DT cord-282610-zim7nond 290 22 pathogen pathogen NN cord-282610-zim7nond 290 23 . . . cord-282610-zim7nond 291 1 Indeed indeed RB cord-282610-zim7nond 291 2 , , , cord-282610-zim7nond 291 3 groups group NNS cord-282610-zim7nond 291 4 of of IN cord-282610-zim7nond 291 5 bacteria bacteria NNS cord-282610-zim7nond 291 6 not not RB cord-282610-zim7nond 291 7 generally generally RB cord-282610-zim7nond 291 8 considered consider VBN cord-282610-zim7nond 291 9 pathogens pathogen NNS cord-282610-zim7nond 291 10 upregulated upregulate VBD cord-282610-zim7nond 291 11 a a DT cord-282610-zim7nond 291 12 large large JJ cord-282610-zim7nond 291 13 number number NN cord-282610-zim7nond 291 14 of of IN cord-282610-zim7nond 291 15 the the DT cord-282610-zim7nond 291 16 putative putative JJ cord-282610-zim7nond 291 17 virulence virulence NN cord-282610-zim7nond 291 18 factors factor NNS cord-282610-zim7nond 291 19 in in IN cord-282610-zim7nond 291 20 active active JJ cord-282610-zim7nond 291 21 sites site NNS cord-282610-zim7nond 291 22 . . . cord-282610-zim7nond 292 1 These these DT cord-282610-zim7nond 292 2 included include VBD cord-282610-zim7nond 292 3 Veillonella Veillonella NNP cord-282610-zim7nond 292 4 parvula parvula NN cord-282610-zim7nond 292 5 , , , cord-282610-zim7nond 292 6 a a DT cord-282610-zim7nond 292 7 microbe microbe NN cord-282610-zim7nond 292 8 almost almost RB cord-282610-zim7nond 292 9 always always RB cord-282610-zim7nond 292 10 associated associate VBN cord-282610-zim7nond 292 11 with with IN cord-282610-zim7nond 292 12 dental dental JJ cord-282610-zim7nond 292 13 health health NN cord-282610-zim7nond 292 14 . . . cord-282610-zim7nond 293 1 Community community NN cord-282610-zim7nond 293 2 - - HYPH cord-282610-zim7nond 293 3 wide wide JJ cord-282610-zim7nond 293 4 shifts shift NNS cord-282610-zim7nond 293 5 in in IN cord-282610-zim7nond 293 6 microbiome microbiome NN cord-282610-zim7nond 293 7 virulence virulence NN cord-282610-zim7nond 293 8 are be VBP cord-282610-zim7nond 293 9 often often RB cord-282610-zim7nond 293 10 driven drive VBN cord-282610-zim7nond 293 11 by by IN cord-282610-zim7nond 293 12 dominant dominant JJ cord-282610-zim7nond 293 13 pathogens pathogen NNS cord-282610-zim7nond 293 14 - - : cord-282610-zim7nond 293 15 organisms organism NNS cord-282610-zim7nond 293 16 that that WDT cord-282610-zim7nond 293 17 become become VBP cord-282610-zim7nond 293 18 established establish VBN cord-282610-zim7nond 293 19 as as IN cord-282610-zim7nond 293 20 central central JJ cord-282610-zim7nond 293 21 components component NNS cord-282610-zim7nond 293 22 of of IN cord-282610-zim7nond 293 23 the the DT cord-282610-zim7nond 293 24 microbiome microbiome NN cord-282610-zim7nond 293 25 while while IN cord-282610-zim7nond 293 26 suppressing suppress VBG cord-282610-zim7nond 293 27 commensal commensal JJ cord-282610-zim7nond 293 28 growth growth NN cord-282610-zim7nond 293 29 and and CC cord-282610-zim7nond 293 30 activity activity NN cord-282610-zim7nond 293 31 ( ( -LRB- cord-282610-zim7nond 293 32 109 109 CD cord-282610-zim7nond 293 33 ) ) -RRB- cord-282610-zim7nond 293 34 . . . cord-282610-zim7nond 294 1 In in IN cord-282610-zim7nond 294 2 other other JJ cord-282610-zim7nond 294 3 cases case NNS cord-282610-zim7nond 294 4 , , , cord-282610-zim7nond 294 5 keystone keystone NN cord-282610-zim7nond 294 6 pathogens pathogen NNS cord-282610-zim7nond 294 7 promote promote VBP cord-282610-zim7nond 294 8 inflammation inflammation NN cord-282610-zim7nond 294 9 even even RB cord-282610-zim7nond 294 10 when when WRB cord-282610-zim7nond 294 11 present present JJ cord-282610-zim7nond 294 12 as as IN cord-282610-zim7nond 294 13 quantitatively quantitatively RB cord-282610-zim7nond 294 14 minor minor JJ cord-282610-zim7nond 294 15 members member NNS cord-282610-zim7nond 294 16 of of IN cord-282610-zim7nond 294 17 the the DT cord-282610-zim7nond 294 18 microbiome microbiome NN cord-282610-zim7nond 294 19 . . . cord-282610-zim7nond 295 1 For for IN cord-282610-zim7nond 295 2 example example NN cord-282610-zim7nond 295 3 , , , cord-282610-zim7nond 295 4 P. P. NNP cord-282610-zim7nond 295 5 gingivalis gingivalis NNP cord-282610-zim7nond 295 6 often often RB cord-282610-zim7nond 295 7 comprises comprise VBZ cord-282610-zim7nond 295 8 just just RB cord-282610-zim7nond 295 9 0.01 0.01 CD cord-282610-zim7nond 295 10 % % NN cord-282610-zim7nond 295 11 of of IN cord-282610-zim7nond 295 12 periodontal periodontal JJ cord-282610-zim7nond 295 13 biofilms biofilm NNS cord-282610-zim7nond 295 14 , , , cord-282610-zim7nond 295 15 yet yet CC cord-282610-zim7nond 295 16 drives drive VBZ cord-282610-zim7nond 295 17 destructive destructive JJ cord-282610-zim7nond 295 18 changes change NNS cord-282610-zim7nond 295 19 in in IN cord-282610-zim7nond 295 20 host host NN cord-282610-zim7nond 295 21 - - HYPH cord-282610-zim7nond 295 22 microbe microbe NN cord-282610-zim7nond 295 23 interplay interplay NN cord-282610-zim7nond 295 24 by by IN cord-282610-zim7nond 295 25 profoundly profoundly RB cord-282610-zim7nond 295 26 impairing impair VBG cord-282610-zim7nond 295 27 the the DT cord-282610-zim7nond 295 28 innate innate JJ cord-282610-zim7nond 295 29 immune immune JJ cord-282610-zim7nond 295 30 response response NN cord-282610-zim7nond 295 31 ( ( -LRB- cord-282610-zim7nond 295 32 110 110 CD cord-282610-zim7nond 295 33 ) ) -RRB- cord-282610-zim7nond 295 34 . . . cord-282610-zim7nond 296 1 Pathogens pathogen NNS cord-282610-zim7nond 296 2 able able JJ cord-282610-zim7nond 296 3 to to TO cord-282610-zim7nond 296 4 persist persist VB cord-282610-zim7nond 296 5 inside inside IN cord-282610-zim7nond 296 6 the the DT cord-282610-zim7nond 296 7 cells cell NNS cord-282610-zim7nond 296 8 of of IN cord-282610-zim7nond 296 9 the the DT cord-282610-zim7nond 296 10 immune immune JJ cord-282610-zim7nond 296 11 system system NN cord-282610-zim7nond 296 12 are be VBP cord-282610-zim7nond 296 13 uniquely uniquely RB cord-282610-zim7nond 296 14 positioned position VBN cord-282610-zim7nond 296 15 to to TO cord-282610-zim7nond 296 16 drive drive VB cord-282610-zim7nond 296 17 inflammatory inflammatory JJ cord-282610-zim7nond 296 18 disease disease NN cord-282610-zim7nond 296 19 ( ( -LRB- cord-282610-zim7nond 296 20 111 111 CD cord-282610-zim7nond 296 21 ) ) -RRB- cord-282610-zim7nond 296 22 . . . cord-282610-zim7nond 297 1 Indeed indeed RB cord-282610-zim7nond 297 2 , , , cord-282610-zim7nond 297 3 most most RBS cord-282610-zim7nond 297 4 well well RB cord-282610-zim7nond 297 5 - - HYPH cord-282610-zim7nond 297 6 characterized characterize VBN cord-282610-zim7nond 297 7 pathogens pathogen NNS cord-282610-zim7nond 297 8 , , , cord-282610-zim7nond 297 9 including include VBG cord-282610-zim7nond 297 10 many many JJ cord-282610-zim7nond 297 11 connected connect VBN cord-282610-zim7nond 297 12 to to IN cord-282610-zim7nond 297 13 ME ME NNP cord-282610-zim7nond 297 14 / / SYM cord-282610-zim7nond 297 15 CFS CFS NNP cord-282610-zim7nond 297 16 , , , cord-282610-zim7nond 297 17 are be VBP cord-282610-zim7nond 297 18 capable capable JJ cord-282610-zim7nond 297 19 of of IN cord-282610-zim7nond 297 20 intracellular intracellular JJ cord-282610-zim7nond 297 21 persistence persistence NN cord-282610-zim7nond 297 22 ( ( -LRB- cord-282610-zim7nond 297 23 112 112 CD cord-282610-zim7nond 297 24 ) ) -RRB- cord-282610-zim7nond 297 25 . . . cord-282610-zim7nond 298 1 By by IN cord-282610-zim7nond 298 2 surviving survive VBG cord-282610-zim7nond 298 3 in in IN cord-282610-zim7nond 298 4 this this DT cord-282610-zim7nond 298 5 fashion fashion NN cord-282610-zim7nond 298 6 , , , cord-282610-zim7nond 298 7 they -PRON- PRP cord-282610-zim7nond 298 8 can can MD cord-282610-zim7nond 298 9 directly directly RB cord-282610-zim7nond 298 10 interfere interfere VB cord-282610-zim7nond 298 11 with with IN cord-282610-zim7nond 298 12 human human JJ cord-282610-zim7nond 298 13 transcription transcription NN cord-282610-zim7nond 298 14 , , , cord-282610-zim7nond 298 15 translation translation NN cord-282610-zim7nond 298 16 , , , cord-282610-zim7nond 298 17 and and CC cord-282610-zim7nond 298 18 DNA dna NN cord-282610-zim7nond 298 19 repair repair NN cord-282610-zim7nond 298 20 processes process NNS cord-282610-zim7nond 298 21 ( ( -LRB- cord-282610-zim7nond 298 22 Figure figure NN cord-282610-zim7nond 298 23 3 3 CD cord-282610-zim7nond 298 24 ) ) -RRB- cord-282610-zim7nond 298 25 . . . cord-282610-zim7nond 299 1 Pathogens pathogen NNS cord-282610-zim7nond 299 2 in in IN cord-282610-zim7nond 299 3 the the DT cord-282610-zim7nond 299 4 cell cell NN cord-282610-zim7nond 299 5 cytoplasm cytoplasm NN cord-282610-zim7nond 299 6 may may MD cord-282610-zim7nond 299 7 further far RBR cord-282610-zim7nond 299 8 dysregulate dysregulate VB cord-282610-zim7nond 299 9 the the DT cord-282610-zim7nond 299 10 epigenetic epigenetic JJ cord-282610-zim7nond 299 11 environment environment NN cord-282610-zim7nond 299 12 ( ( -LRB- cord-282610-zim7nond 299 13 113 113 CD cord-282610-zim7nond 299 14 ) ) -RRB- cord-282610-zim7nond 299 15 . . . cord-282610-zim7nond 300 1 For for IN cord-282610-zim7nond 300 2 example example NN cord-282610-zim7nond 300 3 , , , cord-282610-zim7nond 300 4 upon upon IN cord-282610-zim7nond 300 5 infecting infect VBG cord-282610-zim7nond 300 6 a a DT cord-282610-zim7nond 300 7 macrophage macrophage NN cord-282610-zim7nond 300 8 , , , cord-282610-zim7nond 300 9 Mycobacterium Mycobacterium NNP cord-282610-zim7nond 300 10 tuberculosis tuberculosis NN cord-282610-zim7nond 300 11 alters alter VBZ cord-282610-zim7nond 300 12 the the DT cord-282610-zim7nond 300 13 expression expression NN cord-282610-zim7nond 300 14 of of IN cord-282610-zim7nond 300 15 463 463 CD cord-282610-zim7nond 300 16 human human JJ cord-282610-zim7nond 300 17 genes gene NNS cord-282610-zim7nond 300 18 ( ( -LRB- cord-282610-zim7nond 300 19 114 114 CD cord-282610-zim7nond 300 20 ) ) -RRB- cord-282610-zim7nond 300 21 . . . cord-282610-zim7nond 301 1 H. H. NNP cord-282610-zim7nond 301 2 pylori pylori NN cord-282610-zim7nond 301 3 infection infection NN cord-282610-zim7nond 301 4 predisposes predispose VBZ cord-282610-zim7nond 301 5 to to TO cord-282610-zim7nond 301 6 genomic genomic JJ cord-282610-zim7nond 301 7 instability instability NN cord-282610-zim7nond 301 8 and and CC cord-282610-zim7nond 301 9 DNA dna NN cord-282610-zim7nond 301 10 damage damage NN cord-282610-zim7nond 301 11 , , , cord-282610-zim7nond 301 12 including include VBG cord-282610-zim7nond 301 13 double double JJ cord-282610-zim7nond 301 14 strand strand NN cord-282610-zim7nond 301 15 breaks break NNS cord-282610-zim7nond 301 16 ( ( -LRB- cord-282610-zim7nond 301 17 115 115 CD cord-282610-zim7nond 301 18 ) ) -RRB- cord-282610-zim7nond 301 19 . . . cord-282610-zim7nond 302 1 EBV EBV NNP cord-282610-zim7nond 302 2 infection infection NN cord-282610-zim7nond 302 3 of of IN cord-282610-zim7nond 302 4 B b NN cord-282610-zim7nond 302 5 cells cell NNS cord-282610-zim7nond 302 6 can can MD cord-282610-zim7nond 302 7 also also RB cord-282610-zim7nond 302 8 promote promote VB cord-282610-zim7nond 302 9 persistent persistent JJ cord-282610-zim7nond 302 10 damage damage NN cord-282610-zim7nond 302 11 to to IN cord-282610-zim7nond 302 12 human human JJ cord-282610-zim7nond 302 13 DNA dna NN cord-282610-zim7nond 302 14 ( ( -LRB- cord-282610-zim7nond 302 15 116 116 CD cord-282610-zim7nond 302 16 ) ) -RRB- cord-282610-zim7nond 302 17 . . . cord-282610-zim7nond 303 1 The the DT cord-282610-zim7nond 303 2 thousands thousand NNS cord-282610-zim7nond 303 3 of of IN cord-282610-zim7nond 303 4 metabolites metabolite NNS cord-282610-zim7nond 303 5 and and CC cord-282610-zim7nond 303 6 proteins protein NNS cord-282610-zim7nond 303 7 expressed express VBN cord-282610-zim7nond 303 8 by by IN cord-282610-zim7nond 303 9 intracellular intracellular JJ cord-282610-zim7nond 303 10 pathogens pathogen NNS cord-282610-zim7nond 303 11 also also RB cord-282610-zim7nond 303 12 interact interact VBP cord-282610-zim7nond 303 13 with with IN cord-282610-zim7nond 303 14 the the DT cord-282610-zim7nond 303 15 host host NN cord-282610-zim7nond 303 16 genome genome NN cord-282610-zim7nond 303 17 , , , cord-282610-zim7nond 303 18 further further RB cord-282610-zim7nond 303 19 modifying modify VBG cord-282610-zim7nond 303 20 human human JJ cord-282610-zim7nond 303 21 gene gene NN cord-282610-zim7nond 303 22 expression expression NN cord-282610-zim7nond 303 23 in in IN cord-282610-zim7nond 303 24 a a DT cord-282610-zim7nond 303 25 manner manner NN cord-282610-zim7nond 303 26 that that WDT cord-282610-zim7nond 303 27 promotes promote VBZ cord-282610-zim7nond 303 28 disease disease NN cord-282610-zim7nond 303 29 . . . cord-282610-zim7nond 304 1 Even even RB cord-282610-zim7nond 304 2 bacterial bacterial JJ cord-282610-zim7nond 304 3 quorum quorum NN cord-282610-zim7nond 304 4 sensing sensing NN cord-282610-zim7nond 304 5 peptides peptide NNS cord-282610-zim7nond 304 6 can can MD cord-282610-zim7nond 304 7 dysregulate dysregulate VB cord-282610-zim7nond 304 8 human human JJ cord-282610-zim7nond 304 9 pathway pathway NN cord-282610-zim7nond 304 10 activity activity NN cord-282610-zim7nond 304 11 . . . cord-282610-zim7nond 305 1 Wynendaele Wynendaele NNP cord-282610-zim7nond 305 2 et et NNP cord-282610-zim7nond 305 3 al al NNP cord-282610-zim7nond 305 4 . . . cord-282610-zim7nond 306 1 ( ( -LRB- cord-282610-zim7nond 306 2 117 117 CD cord-282610-zim7nond 306 3 ) ) -RRB- cord-282610-zim7nond 306 4 found find VBD cord-282610-zim7nond 306 5 that that IN cord-282610-zim7nond 306 6 quorum quorum NN cord-282610-zim7nond 306 7 sensing sense VBG cord-282610-zim7nond 306 8 molecules molecule NNS cord-282610-zim7nond 306 9 created create VBN cord-282610-zim7nond 306 10 by by IN cord-282610-zim7nond 306 11 gramnegative gramnegative JJ cord-282610-zim7nond 306 12 bacteria bacteria NNS cord-282610-zim7nond 306 13 altered alter VBD cord-282610-zim7nond 306 14 human human JJ cord-282610-zim7nond 306 15 gene gene NN cord-282610-zim7nond 306 16 expression expression NN cord-282610-zim7nond 306 17 in in IN cord-282610-zim7nond 306 18 a a DT cord-282610-zim7nond 306 19 manner manner NN cord-282610-zim7nond 306 20 that that WDT cord-282610-zim7nond 306 21 promoted promote VBD cord-282610-zim7nond 306 22 in in IN cord-282610-zim7nond 306 23 vitro vitro FW cord-282610-zim7nond 306 24 angiogeneisis angiogeneisis NNP cord-282610-zim7nond 306 25 , , , cord-282610-zim7nond 306 26 tumor tumor NN cord-282610-zim7nond 306 27 growth growth NN cord-282610-zim7nond 306 28 , , , cord-282610-zim7nond 306 29 and and CC cord-282610-zim7nond 306 30 neovascularization neovascularization NN cord-282610-zim7nond 306 31 in in IN cord-282610-zim7nond 306 32 colon colon NN cord-282610-zim7nond 306 33 cancer cancer NN cord-282610-zim7nond 306 34 . . . cord-282610-zim7nond 307 1 Intracellular Intracellular NNP cord-282610-zim7nond 307 2 pathogens pathogen NNS cord-282610-zim7nond 307 3 can can MD cord-282610-zim7nond 307 4 also also RB cord-282610-zim7nond 307 5 travel travel VB cord-282610-zim7nond 307 6 between between IN cord-282610-zim7nond 307 7 cells cell NNS cord-282610-zim7nond 307 8 via via IN cord-282610-zim7nond 307 9 recently recently RB cord-282610-zim7nond 307 10 characterized characterize VBN cord-282610-zim7nond 307 11 tunneling tunnel VBG cord-282610-zim7nond 307 12 nanotubules nanotubule NNS cord-282610-zim7nond 307 13 ( ( -LRB- cord-282610-zim7nond 307 14 TNTs TNTs NNP cord-282610-zim7nond 307 15 ) ) -RRB- cord-282610-zim7nond 307 16 ( ( -LRB- cord-282610-zim7nond 307 17 118 118 CD cord-282610-zim7nond 307 18 , , , cord-282610-zim7nond 307 19 119 119 CD cord-282610-zim7nond 307 20 ) ) -RRB- cord-282610-zim7nond 307 21 . . . cord-282610-zim7nond 308 1 These these DT cord-282610-zim7nond 308 2 cytoplasmic cytoplasmic JJ cord-282610-zim7nond 308 3 extensions extension NNS cord-282610-zim7nond 308 4 of of IN cord-282610-zim7nond 308 5 dendritic dendritic JJ cord-282610-zim7nond 308 6 cells cell NNS cord-282610-zim7nond 308 7 , , , cord-282610-zim7nond 308 8 glial glial JJ cord-282610-zim7nond 308 9 cells cell NNS cord-282610-zim7nond 308 10 and and CC cord-282610-zim7nond 308 11 related relate VBN cord-282610-zim7nond 308 12 human human JJ cord-282610-zim7nond 308 13 cells cell NNS cord-282610-zim7nond 308 14 allow allow VBP cord-282610-zim7nond 308 15 for for IN cord-282610-zim7nond 308 16 the the DT cord-282610-zim7nond 308 17 intracellular intracellular JJ cord-282610-zim7nond 308 18 transfer transfer NN cord-282610-zim7nond 308 19 of of IN cord-282610-zim7nond 308 20 microRNAs microRNAs NNPS cord-282610-zim7nond 308 21 , , , cord-282610-zim7nond 308 22 messenger messenger NN cord-282610-zim7nond 308 23 RNAs rna NNS cord-282610-zim7nond 308 24 , , , cord-282610-zim7nond 308 25 prions prion NNS cord-282610-zim7nond 308 26 , , , cord-282610-zim7nond 308 27 viruses virus NNS cord-282610-zim7nond 308 28 , , , cord-282610-zim7nond 308 29 and and CC cord-282610-zim7nond 308 30 even even RB cord-282610-zim7nond 308 31 whole whole JJ cord-282610-zim7nond 308 32 organelles organelle NNS cord-282610-zim7nond 308 33 such such JJ cord-282610-zim7nond 308 34 as as IN cord-282610-zim7nond 308 35 mitochondria mitochondrion NNS cord-282610-zim7nond 308 36 ( ( -LRB- cord-282610-zim7nond 308 37 120 120 CD cord-282610-zim7nond 308 38 , , , cord-282610-zim7nond 308 39 121 121 CD cord-282610-zim7nond 308 40 ) ) -RRB- cord-282610-zim7nond 308 41 . . . cord-282610-zim7nond 309 1 For for IN cord-282610-zim7nond 309 2 example example NN cord-282610-zim7nond 309 3 , , , cord-282610-zim7nond 309 4 HIVinduced hivinduce VBN cord-282610-zim7nond 309 5 tunneling tunnel VBG cord-282610-zim7nond 309 6 nanotubule nanotubule JJ cord-282610-zim7nond 309 7 formation formation NN cord-282610-zim7nond 309 8 appears appear VBZ cord-282610-zim7nond 309 9 to to TO cord-282610-zim7nond 309 10 mediate mediate VB cord-282610-zim7nond 309 11 approximately approximately RB cord-282610-zim7nond 309 12 half half NN cord-282610-zim7nond 309 13 of of IN cord-282610-zim7nond 309 14 HIV HIV NNP cord-282610-zim7nond 309 15 virus virus NN cord-282610-zim7nond 309 16 spread spread VBD cord-282610-zim7nond 309 17 among among IN cord-282610-zim7nond 309 18 monocytederived monocytederived JJ cord-282610-zim7nond 309 19 macrophages macrophage NNS cord-282610-zim7nond 309 20 ( ( -LRB- cord-282610-zim7nond 309 21 119 119 CD cord-282610-zim7nond 309 22 ) ) -RRB- cord-282610-zim7nond 309 23 . . . cord-282610-zim7nond 310 1 Dysfunction dysfunction NN cord-282610-zim7nond 310 2 driven drive VBN cord-282610-zim7nond 310 3 by by IN cord-282610-zim7nond 310 4 intracellular intracellular JJ cord-282610-zim7nond 310 5 infection infection NN cord-282610-zim7nond 310 6 is be VBZ cord-282610-zim7nond 310 7 compounded compound VBN cord-282610-zim7nond 310 8 by by IN cord-282610-zim7nond 310 9 the the DT cord-282610-zim7nond 310 10 fact fact NN cord-282610-zim7nond 310 11 that that IN cord-282610-zim7nond 310 12 microbial microbial JJ cord-282610-zim7nond 310 13 proteins protein NNS cord-282610-zim7nond 310 14 and and CC cord-282610-zim7nond 310 15 metabolites metabolite NNS cord-282610-zim7nond 310 16 are be VBP cord-282610-zim7nond 310 17 often often RB cord-282610-zim7nond 310 18 identical identical JJ cord-282610-zim7nond 310 19 or or CC cord-282610-zim7nond 310 20 similar similar JJ cord-282610-zim7nond 310 21 in in IN cord-282610-zim7nond 310 22 structure structure NN cord-282610-zim7nond 310 23 to to IN cord-282610-zim7nond 310 24 those those DT cord-282610-zim7nond 310 25 created create VBN cord-282610-zim7nond 310 26 by by IN cord-282610-zim7nond 310 27 their -PRON- PRP$ cord-282610-zim7nond 310 28 human human JJ cord-282610-zim7nond 310 29 hosts host NNS cord-282610-zim7nond 310 30 . . . cord-282610-zim7nond 311 1 The the DT cord-282610-zim7nond 311 2 molecular molecular JJ cord-282610-zim7nond 311 3 mimicry mimicry NN cord-282610-zim7nond 311 4 or or CC cord-282610-zim7nond 311 5 sequence sequence NN cord-282610-zim7nond 311 6 homology homology NN cord-282610-zim7nond 311 7 between between IN cord-282610-zim7nond 311 8 these these DT cord-282610-zim7nond 311 9 proteins protein NNS cord-282610-zim7nond 311 10 and and CC cord-282610-zim7nond 311 11 metabolites metabolite NNS cord-282610-zim7nond 311 12 makes make VBZ cord-282610-zim7nond 311 13 it -PRON- PRP cord-282610-zim7nond 311 14 increasingly increasingly RB cord-282610-zim7nond 311 15 difficult difficult JJ cord-282610-zim7nond 311 16 for for IN cord-282610-zim7nond 311 17 the the DT cord-282610-zim7nond 311 18 human human JJ cord-282610-zim7nond 311 19 holobiont holobiont NN cord-282610-zim7nond 311 20 to to TO cord-282610-zim7nond 311 21 recognize recognize VB cord-282610-zim7nond 311 22 " " `` cord-282610-zim7nond 311 23 foreign foreign JJ cord-282610-zim7nond 311 24 " " '' cord-282610-zim7nond 311 25 from from IN cord-282610-zim7nond 311 26 " " `` cord-282610-zim7nond 311 27 self self NN cord-282610-zim7nond 311 28 . . . cord-282610-zim7nond 312 1 " " '' cord-282610-zim7nond 313 1 For for IN cord-282610-zim7nond 313 2 example example NN cord-282610-zim7nond 313 3 , , , cord-282610-zim7nond 313 4 Altindis Altindis NNP cord-282610-zim7nond 313 5 et et NNP cord-282610-zim7nond 313 6 al al NNP cord-282610-zim7nond 313 7 . . . cord-282610-zim7nond 314 1 ( ( -LRB- cord-282610-zim7nond 314 2 122 122 CD cord-282610-zim7nond 314 3 ) ) -RRB- cord-282610-zim7nond 314 4 found find VBD cord-282610-zim7nond 314 5 that that IN cord-282610-zim7nond 314 6 viruses virus NNS cord-282610-zim7nond 314 7 carry carry VBP cord-282610-zim7nond 314 8 sequences sequence NNS cord-282610-zim7nond 314 9 with with IN cord-282610-zim7nond 314 10 significant significant JJ cord-282610-zim7nond 314 11 homology homology NN cord-282610-zim7nond 314 12 to to IN cord-282610-zim7nond 314 13 human human JJ cord-282610-zim7nond 314 14 insulin insulin NN cord-282610-zim7nond 314 15 - - HYPH cord-282610-zim7nond 314 16 like like JJ cord-282610-zim7nond 314 17 growth growth NN cord-282610-zim7nond 314 18 factors factor NNS cord-282610-zim7nond 314 19 ( ( -LRB- cord-282610-zim7nond 314 20 VILPs VILPs NNP cord-282610-zim7nond 314 21 ) ) -RRB- cord-282610-zim7nond 314 22 . . . cord-282610-zim7nond 315 1 These these DT cord-282610-zim7nond 315 2 VILPs vilp NNS cord-282610-zim7nond 315 3 can can MD cord-282610-zim7nond 315 4 bind bind VB cord-282610-zim7nond 315 5 human human JJ cord-282610-zim7nond 315 6 and and CC cord-282610-zim7nond 315 7 murine murine JJ cord-282610-zim7nond 315 8 IGF-1 IGF-1 NNP cord-282610-zim7nond 315 9 receptors receptor NNS cord-282610-zim7nond 315 10 in in IN cord-282610-zim7nond 315 11 vitro vitro FW cord-282610-zim7nond 315 12 , , , cord-282610-zim7nond 315 13 resulting result VBG cord-282610-zim7nond 315 14 in in IN cord-282610-zim7nond 315 15 autophosphorylation autophosphorylation NN cord-282610-zim7nond 315 16 and and CC cord-282610-zim7nond 315 17 downstream downstream JJ cord-282610-zim7nond 315 18 signaling signaling NN cord-282610-zim7nond 315 19 . . . cord-282610-zim7nond 316 1 E. E. NNP cord-282610-zim7nond 316 2 coli coli VBZ cord-282610-zim7nond 316 3 harbors harbor VBZ cord-282610-zim7nond 316 4 a a DT cord-282610-zim7nond 316 5 large large JJ cord-282610-zim7nond 316 6 , , , cord-282610-zim7nond 316 7 diverse diverse JJ cord-282610-zim7nond 316 8 network network NN cord-282610-zim7nond 316 9 of of IN cord-282610-zim7nond 316 10 proteins protein NNS cord-282610-zim7nond 316 11 that that WDT cord-282610-zim7nond 316 12 actively actively RB cord-282610-zim7nond 316 13 promote promote VBP cord-282610-zim7nond 316 14 endogenous endogenous JJ cord-282610-zim7nond 316 15 DNA dna NN cord-282610-zim7nond 316 16 damage damage NN cord-282610-zim7nond 316 17 in in IN cord-282610-zim7nond 316 18 cells cell NNS cord-282610-zim7nond 316 19 ( ( -LRB- cord-282610-zim7nond 316 20 123 123 CD cord-282610-zim7nond 316 21 ) ) -RRB- cord-282610-zim7nond 316 22 . . . cord-282610-zim7nond 317 1 However however RB cord-282610-zim7nond 317 2 , , , cord-282610-zim7nond 317 3 at at RB cord-282610-zim7nond 317 4 least least JJS cord-282610-zim7nond 317 5 280 280 CD cord-282610-zim7nond 317 6 of of IN cord-282610-zim7nond 317 7 these these DT cord-282610-zim7nond 317 8 DNA dna NN cord-282610-zim7nond 317 9 - - HYPH cord-282610-zim7nond 317 10 damaging damaging JJ cord-282610-zim7nond 317 11 proteins protein NNS cord-282610-zim7nond 317 12 have have VBP cord-282610-zim7nond 317 13 human human JJ cord-282610-zim7nond 317 14 homologs homolog NNS cord-282610-zim7nond 317 15 that that WDT cord-282610-zim7nond 317 16 also also RB cord-282610-zim7nond 317 17 promote promote VBP cord-282610-zim7nond 317 18 DNA dna NN cord-282610-zim7nond 317 19 damage damage NN cord-282610-zim7nond 317 20 and and CC cord-282610-zim7nond 317 21 mutagenesis mutagenesis NN cord-282610-zim7nond 317 22 in in IN cord-282610-zim7nond 317 23 the the DT cord-282610-zim7nond 317 24 human human JJ cord-282610-zim7nond 317 25 host host NN cord-282610-zim7nond 317 26 . . . cord-282610-zim7nond 318 1 Indeed indeed RB cord-282610-zim7nond 318 2 , , , cord-282610-zim7nond 318 3 redundancy redundancy NN cord-282610-zim7nond 318 4 between between IN cord-282610-zim7nond 318 5 human human JJ cord-282610-zim7nond 318 6 and and CC cord-282610-zim7nond 318 7 microbial microbial JJ cord-282610-zim7nond 318 8 metabolites metabolite NNS cord-282610-zim7nond 318 9 , , , cord-282610-zim7nond 318 10 proteins protein NNS cord-282610-zim7nond 318 11 , , , cord-282610-zim7nond 318 12 and and CC cord-282610-zim7nond 318 13 pathways pathway NNS cord-282610-zim7nond 318 14 is be VBZ cord-282610-zim7nond 318 15 so so RB cord-282610-zim7nond 318 16 great great JJ cord-282610-zim7nond 318 17 that that IN cord-282610-zim7nond 318 18 the the DT cord-282610-zim7nond 318 19 potential potential NN cord-282610-zim7nond 318 20 for for IN cord-282610-zim7nond 318 21 molecular molecular JJ cord-282610-zim7nond 318 22 mimicry mimicry NN cord-282610-zim7nond 318 23 to to TO cord-282610-zim7nond 318 24 contribute contribute VB cord-282610-zim7nond 318 25 to to TO cord-282610-zim7nond 318 26 host host NN cord-282610-zim7nond 318 27 immune immune JJ cord-282610-zim7nond 318 28 and and CC cord-282610-zim7nond 318 29 metabolic metabolic JJ cord-282610-zim7nond 318 30 dysfunction dysfunction NN cord-282610-zim7nond 318 31 is be VBZ cord-282610-zim7nond 318 32 semi semi JJ cord-282610-zim7nond 318 33 - - JJ cord-282610-zim7nond 318 34 infinite infinite JJ cord-282610-zim7nond 318 35 . . . cord-282610-zim7nond 319 1 For for IN cord-282610-zim7nond 319 2 example example NN cord-282610-zim7nond 319 3 , , , cord-282610-zim7nond 319 4 viral viral JJ cord-282610-zim7nond 319 5 vesicles vesicle NNS cord-282610-zim7nond 319 6 and and CC cord-282610-zim7nond 319 7 human human JJ cord-282610-zim7nond 319 8 extracellular extracellular JJ cord-282610-zim7nond 319 9 vesicles vesicle NNS cord-282610-zim7nond 319 10 ( ( -LRB- cord-282610-zim7nond 319 11 EVs ev NNS cord-282610-zim7nond 319 12 ) ) -RRB- cord-282610-zim7nond 319 13 share share VBP cord-282610-zim7nond 319 14 considerable considerable JJ cord-282610-zim7nond 319 15 structural structural JJ cord-282610-zim7nond 319 16 and and CC cord-282610-zim7nond 319 17 functional functional JJ cord-282610-zim7nond 319 18 similarity similarity NN cord-282610-zim7nond 319 19 ( ( -LRB- cord-282610-zim7nond 319 20 124 124 CD cord-282610-zim7nond 319 21 ) ) -RRB- cord-282610-zim7nond 319 22 . . . cord-282610-zim7nond 320 1 These these DT cord-282610-zim7nond 320 2 similarities similarity NNS cord-282610-zim7nond 320 3 are be VBP cord-282610-zim7nond 320 4 so so RB cord-282610-zim7nond 320 5 extensive extensive JJ cord-282610-zim7nond 320 6 that that IN cord-282610-zim7nond 320 7 it -PRON- PRP cord-282610-zim7nond 320 8 is be VBZ cord-282610-zim7nond 320 9 difficult difficult JJ cord-282610-zim7nond 320 10 to to TO cord-282610-zim7nond 320 11 distinguish distinguish VB cord-282610-zim7nond 320 12 EVs ev NNS cord-282610-zim7nond 320 13 from from IN cord-282610-zim7nond 320 14 ( ( -LRB- cord-282610-zim7nond 320 15 noninfectious noninfectious JJ cord-282610-zim7nond 320 16 ) ) -RRB- cord-282610-zim7nond 320 17 viruses virus NNS cord-282610-zim7nond 320 18 . . . cord-282610-zim7nond 321 1 Many many JJ cord-282610-zim7nond 321 2 pathogens pathogen NNS cord-282610-zim7nond 321 3 employ employ VBP cord-282610-zim7nond 321 4 common common JJ cord-282610-zim7nond 321 5 survival survival NN cord-282610-zim7nond 321 6 mechanisms mechanism NNS cord-282610-zim7nond 321 7 to to TO cord-282610-zim7nond 321 8 persist persist VB cord-282610-zim7nond 321 9 in in IN cord-282610-zim7nond 321 10 host host NN cord-282610-zim7nond 321 11 cells cell NNS cord-282610-zim7nond 321 12 , , , cord-282610-zim7nond 321 13 tissue tissue NN cord-282610-zim7nond 321 14 and and CC cord-282610-zim7nond 321 15 blood blood NN cord-282610-zim7nond 321 16 . . . cord-282610-zim7nond 322 1 The the DT cord-282610-zim7nond 322 2 metabolic metabolic JJ cord-282610-zim7nond 322 3 dysfunction dysfunction NN cord-282610-zim7nond 322 4 driven drive VBN cord-282610-zim7nond 322 5 by by IN cord-282610-zim7nond 322 6 these these DT cord-282610-zim7nond 322 7 different different JJ cord-282610-zim7nond 322 8 microbes microbe NNS cord-282610-zim7nond 322 9 and and CC cord-282610-zim7nond 322 10 viruses virus NNS cord-282610-zim7nond 322 11 can can MD cord-282610-zim7nond 322 12 result result VB cord-282610-zim7nond 322 13 in in IN cord-282610-zim7nond 322 14 similar similar JJ cord-282610-zim7nond 322 15 clusters cluster NNS cord-282610-zim7nond 322 16 of of IN cord-282610-zim7nond 322 17 human human JJ cord-282610-zim7nond 322 18 inflammatory inflammatory JJ cord-282610-zim7nond 322 19 symptoms symptom NNS cord-282610-zim7nond 322 20 . . . cord-282610-zim7nond 323 1 The the DT cord-282610-zim7nond 323 2 ability ability NN cord-282610-zim7nond 323 3 of of IN cord-282610-zim7nond 323 4 various various JJ cord-282610-zim7nond 323 5 pathogens pathogen NNS cord-282610-zim7nond 323 6 to to TO cord-282610-zim7nond 323 7 dysregulate dysregulate VB cord-282610-zim7nond 323 8 activity activity NN cord-282610-zim7nond 323 9 of of IN cord-282610-zim7nond 323 10 the the DT cord-282610-zim7nond 323 11 Vitamin vitamin NN cord-282610-zim7nond 323 12 D D NNP cord-282610-zim7nond 323 13 Nuclear Nuclear NNP cord-282610-zim7nond 323 14 Receptor Receptor NNP cord-282610-zim7nond 323 15 ( ( -LRB- cord-282610-zim7nond 323 16 VDR VDR NNP cord-282610-zim7nond 323 17 ) ) -RRB- cord-282610-zim7nond 323 18 is be VBZ cord-282610-zim7nond 323 19 an an DT cord-282610-zim7nond 323 20 excellent excellent JJ cord-282610-zim7nond 323 21 example example NN cord-282610-zim7nond 323 22 of of IN cord-282610-zim7nond 323 23 how how WRB cord-282610-zim7nond 323 24 different different JJ cord-282610-zim7nond 323 25 microbes microbe NNS cord-282610-zim7nond 323 26 can can MD cord-282610-zim7nond 323 27 drive drive VB cord-282610-zim7nond 323 28 similar similar JJ cord-282610-zim7nond 323 29 disease disease NN cord-282610-zim7nond 323 30 processes process NNS cord-282610-zim7nond 323 31 . . . cord-282610-zim7nond 324 1 The the DT cord-282610-zim7nond 324 2 VDR VDR NNP cord-282610-zim7nond 324 3 regulates regulate VBZ cord-282610-zim7nond 324 4 expression expression NN cord-282610-zim7nond 324 5 of of IN cord-282610-zim7nond 324 6 hundreds hundred NNS cord-282610-zim7nond 324 7 of of IN cord-282610-zim7nond 324 8 human human JJ cord-282610-zim7nond 324 9 genes gene NNS cord-282610-zim7nond 324 10 , , , cord-282610-zim7nond 324 11 many many JJ cord-282610-zim7nond 324 12 of of IN cord-282610-zim7nond 324 13 which which WDT cord-282610-zim7nond 324 14 regulate regulate VBP cord-282610-zim7nond 324 15 inflammatory inflammatory JJ cord-282610-zim7nond 324 16 and and CC cord-282610-zim7nond 324 17 malignant malignant JJ cord-282610-zim7nond 324 18 processes process NNS cord-282610-zim7nond 324 19 ( ( -LRB- cord-282610-zim7nond 324 20 125 125 CD cord-282610-zim7nond 324 21 , , , cord-282610-zim7nond 324 22 126 126 CD cord-282610-zim7nond 324 23 ) ) -RRB- cord-282610-zim7nond 324 24 . . . cord-282610-zim7nond 325 1 The the DT cord-282610-zim7nond 325 2 receptor receptor NN cord-282610-zim7nond 325 3 also also RB cord-282610-zim7nond 325 4 controls control VBZ cord-282610-zim7nond 325 5 signaling signaling NN cord-282610-zim7nond 325 6 of of IN cord-282610-zim7nond 325 7 TLR2 TLR2 NNP cord-282610-zim7nond 325 8 and and CC cord-282610-zim7nond 325 9 several several JJ cord-282610-zim7nond 325 10 families family NNS cord-282610-zim7nond 325 11 of of IN cord-282610-zim7nond 325 12 antimicrobial antimicrobial JJ cord-282610-zim7nond 325 13 peptides peptide NNS cord-282610-zim7nond 325 14 including include VBG cord-282610-zim7nond 325 15 cathelicidin cathelicidin NNP cord-282610-zim7nond 325 16 ( ( -LRB- cord-282610-zim7nond 325 17 LL-37 LL-37 NNP cord-282610-zim7nond 325 18 ) ) -RRB- cord-282610-zim7nond 325 19 ( ( -LRB- cord-282610-zim7nond 325 20 127 127 CD cord-282610-zim7nond 325 21 ) ) -RRB- cord-282610-zim7nond 325 22 . . . cord-282610-zim7nond 326 1 Pathogens pathogen NNS cord-282610-zim7nond 326 2 capable capable JJ cord-282610-zim7nond 326 3 of of IN cord-282610-zim7nond 326 4 slowing slow VBG cord-282610-zim7nond 326 5 VDR vdr NN cord-282610-zim7nond 326 6 activity activity NN cord-282610-zim7nond 326 7 can can MD cord-282610-zim7nond 326 8 subsequently subsequently RB cord-282610-zim7nond 326 9 facilitate facilitate VB cord-282610-zim7nond 326 10 their -PRON- PRP$ cord-282610-zim7nond 326 11 survival survival NN cord-282610-zim7nond 326 12 by by IN cord-282610-zim7nond 326 13 slowing slow VBG cord-282610-zim7nond 326 14 the the DT cord-282610-zim7nond 326 15 innate innate JJ cord-282610-zim7nond 326 16 immune immune JJ cord-282610-zim7nond 326 17 response response NN cord-282610-zim7nond 326 18 . . . cord-282610-zim7nond 327 1 Pathogens pathogen NNS cord-282610-zim7nond 327 2 frequently frequently RB cord-282610-zim7nond 327 3 linked link VBN cord-282610-zim7nond 327 4 to to IN cord-282610-zim7nond 327 5 ME ME NNP cord-282610-zim7nond 327 6 / / SYM cord-282610-zim7nond 327 7 CFS cfs NN cord-282610-zim7nond 327 8 or or CC cord-282610-zim7nond 327 9 inflammatory inflammatory JJ cord-282610-zim7nond 327 10 disease disease NN cord-282610-zim7nond 327 11 have have VBP cord-282610-zim7nond 327 12 evolved evolve VBN cord-282610-zim7nond 327 13 to to TO cord-282610-zim7nond 327 14 survive survive VB cord-282610-zim7nond 327 15 in in IN cord-282610-zim7nond 327 16 this this DT cord-282610-zim7nond 327 17 fashion fashion NN cord-282610-zim7nond 327 18 . . . cord-282610-zim7nond 328 1 VDR VDR NNP cord-282610-zim7nond 328 2 activity activity NN cord-282610-zim7nond 328 3 is be VBZ cord-282610-zim7nond 328 4 downregulated downregulate VBN cord-282610-zim7nond 328 5 as as RB cord-282610-zim7nond 328 6 much much JJ cord-282610-zim7nond 328 7 as as IN cord-282610-zim7nond 328 8 20 20 CD cord-282610-zim7nond 328 9 times time NNS cord-282610-zim7nond 328 10 in in IN cord-282610-zim7nond 328 11 Epstein Epstein NNP cord-282610-zim7nond 328 12 Barr Barr NNP cord-282610-zim7nond 328 13 Virus Virus NNP cord-282610-zim7nond 328 14 - - HYPH cord-282610-zim7nond 328 15 infected infect VBN cord-282610-zim7nond 328 16 lymphoblastoid lymphoblastoid NN cord-282610-zim7nond 328 17 cell cell NN cord-282610-zim7nond 328 18 lines line NNS cord-282610-zim7nond 328 19 ( ( -LRB- cord-282610-zim7nond 328 20 128 128 CD cord-282610-zim7nond 328 21 ) ) -RRB- cord-282610-zim7nond 329 1 ( ( -LRB- cord-282610-zim7nond 329 2 Figure figure NN cord-282610-zim7nond 329 3 4 4 CD cord-282610-zim7nond 329 4 ) ) -RRB- cord-282610-zim7nond 329 5 . . . cord-282610-zim7nond 330 1 HIV HIV NNP cord-282610-zim7nond 330 2 , , , cord-282610-zim7nond 330 3 M. M. NNP cord-282610-zim7nond 330 4 tuberculosis tuberculosis NN cord-282610-zim7nond 330 5 Cytomegalovirus Cytomegalovirus NNP cord-282610-zim7nond 330 6 , , , cord-282610-zim7nond 330 7 Borrelia Borrelia NNP cord-282610-zim7nond 330 8 burgdorferi burgdorferi NN cord-282610-zim7nond 330 9 and and CC cord-282610-zim7nond 330 10 Mycobacterium Mycobacterium NNP cord-282610-zim7nond 330 11 leprae leprae NNP cord-282610-zim7nond 330 12 additionally additionally RB cord-282610-zim7nond 330 13 dysregulate dysregulate VBP cord-282610-zim7nond 330 14 VDR VDR NNP cord-282610-zim7nond 330 15 activity activity NN cord-282610-zim7nond 330 16 to to IN cord-282610-zim7nond 330 17 various various JJ cord-282610-zim7nond 330 18 degrees degree NNS cord-282610-zim7nond 330 19 ( ( -LRB- cord-282610-zim7nond 330 20 114 114 CD cord-282610-zim7nond 330 21 , , , cord-282610-zim7nond 330 22 ( ( -LRB- cord-282610-zim7nond 330 23 129 129 CD cord-282610-zim7nond 330 24 ) ) -RRB- cord-282610-zim7nond 330 25 ( ( -LRB- cord-282610-zim7nond 330 26 130 130 CD cord-282610-zim7nond 330 27 ) ) -RRB- cord-282610-zim7nond 330 28 ( ( -LRB- cord-282610-zim7nond 330 29 131 131 CD cord-282610-zim7nond 330 30 ) ) -RRB- cord-282610-zim7nond 330 31 ( ( -LRB- cord-282610-zim7nond 330 32 132 132 CD cord-282610-zim7nond 330 33 ) ) -RRB- cord-282610-zim7nond 330 34 . . . cord-282610-zim7nond 331 1 The the DT cord-282610-zim7nond 331 2 fungus fungus NN cord-282610-zim7nond 331 3 Aspergillus aspergillus NN cord-282610-zim7nond 331 4 fumigatus fumigatus NN cord-282610-zim7nond 331 5 secretes secrete VBZ cord-282610-zim7nond 331 6 a a DT cord-282610-zim7nond 331 7 gliotoxin gliotoxin NN cord-282610-zim7nond 331 8 that that WDT cord-282610-zim7nond 331 9 significantly significantly RB cord-282610-zim7nond 331 10 downregulates downregulate VBZ cord-282610-zim7nond 331 11 VDR VDR NNP cord-282610-zim7nond 331 12 expression expression NN cord-282610-zim7nond 331 13 ( ( -LRB- cord-282610-zim7nond 331 14 133 133 CD cord-282610-zim7nond 331 15 ) ) -RRB- cord-282610-zim7nond 331 16 . . . cord-282610-zim7nond 332 1 Because because IN cord-282610-zim7nond 332 2 disabling disable VBG cord-282610-zim7nond 332 3 the the DT cord-282610-zim7nond 332 4 innate innate JJ cord-282610-zim7nond 332 5 immune immune JJ cord-282610-zim7nond 332 6 system system NN cord-282610-zim7nond 332 7 via via IN cord-282610-zim7nond 332 8 the the DT cord-282610-zim7nond 332 9 VDR VDR NNP cord-282610-zim7nond 332 10 pathway pathway NN cord-282610-zim7nond 332 11 is be VBZ cord-282610-zim7nond 332 12 such such PDT cord-282610-zim7nond 332 13 a a DT cord-282610-zim7nond 332 14 logical logical JJ cord-282610-zim7nond 332 15 survival survival NN cord-282610-zim7nond 332 16 mechanism mechanism NN cord-282610-zim7nond 332 17 , , , cord-282610-zim7nond 332 18 other other JJ cord-282610-zim7nond 332 19 uncharacterized uncharacterized JJ cord-282610-zim7nond 332 20 bacteria bacteria NNS cord-282610-zim7nond 332 21 , , , cord-282610-zim7nond 332 22 viruses virus NNS cord-282610-zim7nond 332 23 or or CC cord-282610-zim7nond 332 24 fungi fungus NNS cord-282610-zim7nond 332 25 may may MD cord-282610-zim7nond 332 26 have have VB cord-282610-zim7nond 332 27 also also RB cord-282610-zim7nond 332 28 evolved evolve VBN cord-282610-zim7nond 332 29 to to TO cord-282610-zim7nond 332 30 dysregulate dysregulate VB cord-282610-zim7nond 332 31 receptor receptor NN cord-282610-zim7nond 332 32 activity activity NN cord-282610-zim7nond 332 33 . . . cord-282610-zim7nond 333 1 It -PRON- PRP cord-282610-zim7nond 333 2 follows follow VBZ cord-282610-zim7nond 333 3 that that IN cord-282610-zim7nond 333 4 ME ME NNP cord-282610-zim7nond 333 5 / / SYM cord-282610-zim7nond 333 6 CFS CFS NNP cord-282610-zim7nond 333 7 patients patient NNS cord-282610-zim7nond 333 8 with with IN cord-282610-zim7nond 333 9 similar similar JJ cord-282610-zim7nond 333 10 symptoms symptom NNS cord-282610-zim7nond 333 11 may may MD cord-282610-zim7nond 333 12 not not RB cord-282610-zim7nond 333 13 always always RB cord-282610-zim7nond 333 14 test test VB cord-282610-zim7nond 333 15 positive positive JJ cord-282610-zim7nond 333 16 for for IN cord-282610-zim7nond 333 17 the the DT cord-282610-zim7nond 333 18 same same JJ cord-282610-zim7nond 333 19 mix mix NN cord-282610-zim7nond 333 20 of of IN cord-282610-zim7nond 333 21 pathogens pathogen NNS cord-282610-zim7nond 333 22 and/or and/or CC cord-282610-zim7nond 333 23 communities community NNS cord-282610-zim7nond 333 24 of of IN cord-282610-zim7nond 333 25 pathobionts pathobiont NNS cord-282610-zim7nond 333 26 . . . cord-282610-zim7nond 334 1 Similarly similarly RB cord-282610-zim7nond 334 2 , , , cord-282610-zim7nond 334 3 composition composition NN cord-282610-zim7nond 334 4 of of IN cord-282610-zim7nond 334 5 the the DT cord-282610-zim7nond 334 6 ME ME NNP cord-282610-zim7nond 334 7 / / SYM cord-282610-zim7nond 334 8 CFS CFS NNP cord-282610-zim7nond 334 9 microbiome microbiome NN cord-282610-zim7nond 334 10 , , , cord-282610-zim7nond 334 11 proteome proteome NN cord-282610-zim7nond 334 12 and and CC cord-282610-zim7nond 334 13 metabolome metabolome NN cord-282610-zim7nond 334 14 should should MD cord-282610-zim7nond 334 15 be be VB cord-282610-zim7nond 334 16 expected expect VBN cord-282610-zim7nond 334 17 to to TO cord-282610-zim7nond 334 18 differ differ VB cord-282610-zim7nond 334 19 somewhat somewhat RB cord-282610-zim7nond 334 20 from from IN cord-282610-zim7nond 334 21 study study NN cord-282610-zim7nond 334 22 to to TO cord-282610-zim7nond 334 23 study study VB cord-282610-zim7nond 334 24 . . . cord-282610-zim7nond 335 1 Instead instead RB cord-282610-zim7nond 335 2 of of IN cord-282610-zim7nond 335 3 worrying worry VBG cord-282610-zim7nond 335 4 about about IN cord-282610-zim7nond 335 5 these these DT cord-282610-zim7nond 335 6 inconsistencies inconsistency NNS cord-282610-zim7nond 335 7 , , , cord-282610-zim7nond 335 8 the the DT cord-282610-zim7nond 335 9 ME ME NNP cord-282610-zim7nond 335 10 / / SYM cord-282610-zim7nond 335 11 CFS CFS NNP cord-282610-zim7nond 335 12 research research NN cord-282610-zim7nond 335 13 community community NN cord-282610-zim7nond 335 14 should should MD cord-282610-zim7nond 335 15 strive strive VB cord-282610-zim7nond 335 16 to to TO cord-282610-zim7nond 335 17 better better RB cord-282610-zim7nond 335 18 characterize characterize VB cord-282610-zim7nond 335 19 even even RB cord-282610-zim7nond 335 20 more more RBR cord-282610-zim7nond 335 21 common common JJ cord-282610-zim7nond 335 22 mechanisms mechanism NNS cord-282610-zim7nond 335 23 of of IN cord-282610-zim7nond 335 24 pathogen pathogen NN cord-282610-zim7nond 335 25 survival survival NN cord-282610-zim7nond 335 26 and and CC cord-282610-zim7nond 335 27 persistence persistence NN cord-282610-zim7nond 335 28 . . . cord-282610-zim7nond 336 1 The the DT cord-282610-zim7nond 336 2 ability ability NN cord-282610-zim7nond 336 3 of of IN cord-282610-zim7nond 336 4 pathogens pathogen NNS cord-282610-zim7nond 336 5 to to TO cord-282610-zim7nond 336 6 disable disable VB cord-282610-zim7nond 336 7 the the DT cord-282610-zim7nond 336 8 host host NN cord-282610-zim7nond 336 9 immune immune JJ cord-282610-zim7nond 336 10 response response NN cord-282610-zim7nond 336 11 extends extend VBZ cord-282610-zim7nond 336 12 far far RB cord-282610-zim7nond 336 13 beyond beyond IN cord-282610-zim7nond 336 14 the the DT cord-282610-zim7nond 336 15 VDR VDR NNP cord-282610-zim7nond 336 16 pathway pathway NN cord-282610-zim7nond 336 17 . . . cord-282610-zim7nond 337 1 Pushalkar Pushalkar NNP cord-282610-zim7nond 337 2 et et FW cord-282610-zim7nond 337 3 al al NNP cord-282610-zim7nond 337 4 . . . cord-282610-zim7nond 338 1 ( ( -LRB- cord-282610-zim7nond 338 2 134 134 CD cord-282610-zim7nond 338 3 ) ) -RRB- cord-282610-zim7nond 338 4 identified identify VBD cord-282610-zim7nond 338 5 a a DT cord-282610-zim7nond 338 6 distinct distinct JJ cord-282610-zim7nond 338 7 and and CC cord-282610-zim7nond 338 8 abundant abundant JJ cord-282610-zim7nond 338 9 pancreatic pancreatic NN cord-282610-zim7nond 338 10 microbiome microbiome NN cord-282610-zim7nond 338 11 associated associate VBN cord-282610-zim7nond 338 12 with with IN cord-282610-zim7nond 338 13 progressive progressive JJ cord-282610-zim7nond 338 14 pancreatic pancreatic JJ cord-282610-zim7nond 338 15 cancer cancer NN cord-282610-zim7nond 338 16 . . . cord-282610-zim7nond 339 1 This this DT cord-282610-zim7nond 339 2 dysbiotic dysbiotic JJ cord-282610-zim7nond 339 3 microbiome microbiome NN cord-282610-zim7nond 339 4 drove drive VBD cord-282610-zim7nond 339 5 oncogenesis oncogenesis NNP cord-282610-zim7nond 339 6 by by IN cord-282610-zim7nond 339 7 suppressing suppress VBG cord-282610-zim7nond 339 8 macrophage macrophage NN cord-282610-zim7nond 339 9 differentiation differentiation NN cord-282610-zim7nond 339 10 and and CC cord-282610-zim7nond 339 11 T t NN cord-282610-zim7nond 339 12 cell cell NN cord-282610-zim7nond 339 13 activity activity NN cord-282610-zim7nond 339 14 . . . cord-282610-zim7nond 340 1 Another another DT cord-282610-zim7nond 340 2 study study NN cord-282610-zim7nond 340 3 found find VBD cord-282610-zim7nond 340 4 that that IN cord-282610-zim7nond 340 5 Candida Candida NNP cord-282610-zim7nond 340 6 albicans albican NNS cord-282610-zim7nond 340 7 's 's POS cord-282610-zim7nond 340 8 transition transition NN cord-282610-zim7nond 340 9 from from IN cord-282610-zim7nond 340 10 extracellular extracellular JJ cord-282610-zim7nond 340 11 to to IN cord-282610-zim7nond 340 12 intracellular intracellular JJ cord-282610-zim7nond 340 13 pathogen pathogen NN cord-282610-zim7nond 340 14 was be VBD cord-282610-zim7nond 340 15 accompanied accompany VBN cord-282610-zim7nond 340 16 by by IN cord-282610-zim7nond 340 17 a a DT cord-282610-zim7nond 340 18 coordinated coordinated JJ cord-282610-zim7nond 340 19 , , , cord-282610-zim7nond 340 20 time time NN cord-282610-zim7nond 340 21 - - HYPH cord-282610-zim7nond 340 22 dependent dependent JJ cord-282610-zim7nond 340 23 shift shift NN cord-282610-zim7nond 340 24 in in IN cord-282610-zim7nond 340 25 gene gene NN cord-282610-zim7nond 340 26 expression expression NN cord-282610-zim7nond 340 27 for for IN cord-282610-zim7nond 340 28 both both DT cord-282610-zim7nond 340 29 host host NN cord-282610-zim7nond 340 30 and and CC cord-282610-zim7nond 340 31 fungus fungus NN cord-282610-zim7nond 340 32 ( ( -LRB- cord-282610-zim7nond 340 33 135 135 CD cord-282610-zim7nond 340 34 ) ) -RRB- cord-282610-zim7nond 340 35 . . . cord-282610-zim7nond 341 1 These these DT cord-282610-zim7nond 341 2 gene gene NN cord-282610-zim7nond 341 3 expression expression NN cord-282610-zim7nond 341 4 changes change NNS cord-282610-zim7nond 341 5 led lead VBD cord-282610-zim7nond 341 6 to to IN cord-282610-zim7nond 341 7 a a DT cord-282610-zim7nond 341 8 gradual gradual JJ cord-282610-zim7nond 341 9 decline decline NN cord-282610-zim7nond 341 10 in in IN cord-282610-zim7nond 341 11 proinflammatory proinflammatory JJ cord-282610-zim7nond 341 12 cytokine cytokine NN cord-282610-zim7nond 341 13 activation activation NN cord-282610-zim7nond 341 14 by by IN cord-282610-zim7nond 341 15 the the DT cord-282610-zim7nond 341 16 host host NN cord-282610-zim7nond 341 17 immune immune JJ cord-282610-zim7nond 341 18 system system NN cord-282610-zim7nond 341 19 . . . cord-282610-zim7nond 342 1 These these DT cord-282610-zim7nond 342 2 findings finding NNS cord-282610-zim7nond 342 3 shed shed VBP cord-282610-zim7nond 342 4 light light NN cord-282610-zim7nond 342 5 on on IN cord-282610-zim7nond 342 6 a a DT cord-282610-zim7nond 342 7 recent recent JJ cord-282610-zim7nond 342 8 ME ME NNP cord-282610-zim7nond 342 9 / / SYM cord-282610-zim7nond 342 10 CFS CFS NNP cord-282610-zim7nond 342 11 study study NN cord-282610-zim7nond 342 12 . . . cord-282610-zim7nond 343 1 Hornig Hornig NNP cord-282610-zim7nond 343 2 et et NNP cord-282610-zim7nond 343 3 al al NNP cord-282610-zim7nond 343 4 . . . cord-282610-zim7nond 344 1 ( ( -LRB- cord-282610-zim7nond 344 2 5 5 LS cord-282610-zim7nond 344 3 ) ) -RRB- cord-282610-zim7nond 344 4 reported report VBD cord-282610-zim7nond 344 5 distinct distinct JJ cord-282610-zim7nond 344 6 alterations alteration NNS cord-282610-zim7nond 344 7 in in IN cord-282610-zim7nond 344 8 plasma plasma NN cord-282610-zim7nond 344 9 immune immune JJ cord-282610-zim7nond 344 10 signatures signature NNS cord-282610-zim7nond 344 11 - - : cord-282610-zim7nond 344 12 including include VBG cord-282610-zim7nond 344 13 prominent prominent JJ cord-282610-zim7nond 344 14 activation activation NN cord-282610-zim7nond 344 15 of of IN cord-282610-zim7nond 344 16 both both CC cord-282610-zim7nond 344 17 pro pro JJ cord-282610-zim7nond 344 18 - - JJ cord-282610-zim7nond 344 19 and and CC cord-282610-zim7nond 344 20 anti anti JJ cord-282610-zim7nond 344 21 - - JJ cord-282610-zim7nond 344 22 inflammatory inflammatory JJ cord-282610-zim7nond 344 23 cytokines cytokine NNS cord-282610-zim7nond 344 24 - - : cord-282610-zim7nond 344 25 early early RB cord-282610-zim7nond 344 26 in in IN cord-282610-zim7nond 344 27 the the DT cord-282610-zim7nond 344 28 course course NN cord-282610-zim7nond 344 29 of of IN cord-282610-zim7nond 344 30 ME ME NNP cord-282610-zim7nond 344 31 / / SYM cord-282610-zim7nond 344 32 CFS CFS NNP cord-282610-zim7nond 344 33 . . . cord-282610-zim7nond 345 1 However however RB cord-282610-zim7nond 345 2 , , , cord-282610-zim7nond 345 3 these these DT cord-282610-zim7nond 345 4 alterations alteration NNS cord-282610-zim7nond 345 5 were be VBD cord-282610-zim7nond 345 6 not not RB cord-282610-zim7nond 345 7 observed observe VBN cord-282610-zim7nond 345 8 in in IN cord-282610-zim7nond 345 9 subjects subject NNS cord-282610-zim7nond 345 10 with with IN cord-282610-zim7nond 345 11 a a DT cord-282610-zim7nond 345 12 longer long JJR cord-282610-zim7nond 345 13 duration duration NN cord-282610-zim7nond 345 14 of of IN cord-282610-zim7nond 345 15 illness illness NN cord-282610-zim7nond 345 16 . . . cord-282610-zim7nond 346 1 There there EX cord-282610-zim7nond 346 2 are be VBP cord-282610-zim7nond 346 3 a a DT cord-282610-zim7nond 346 4 number number NN cord-282610-zim7nond 346 5 of of IN cord-282610-zim7nond 346 6 explanations explanation NNS cord-282610-zim7nond 346 7 for for IN cord-282610-zim7nond 346 8 Hornig Hornig NNP cord-282610-zim7nond 346 9 's 's POS cord-282610-zim7nond 346 10 observations observation NNS cord-282610-zim7nond 346 11 . . . cord-282610-zim7nond 347 1 ME ME NNP cord-282610-zim7nond 347 2 / / SYM cord-282610-zim7nond 347 3 CFS cfs NN cord-282610-zim7nond 347 4 - - HYPH cord-282610-zim7nond 347 5 associated associate VBN cord-282610-zim7nond 347 6 pathogens pathogen NNS cord-282610-zim7nond 347 7 may may MD cord-282610-zim7nond 347 8 gradually gradually RB cord-282610-zim7nond 347 9 alter alter VB cord-282610-zim7nond 347 10 their -PRON- PRP$ cord-282610-zim7nond 347 11 gene gene NN cord-282610-zim7nond 347 12 activity activity NN cord-282610-zim7nond 347 13 to to TO cord-282610-zim7nond 347 14 persist persist VB cord-282610-zim7nond 347 15 in in IN cord-282610-zim7nond 347 16 more more RBR cord-282610-zim7nond 347 17 latent latent JJ cord-282610-zim7nond 347 18 , , , cord-282610-zim7nond 347 19 intracellular intracellular JJ cord-282610-zim7nond 347 20 forms form NNS cord-282610-zim7nond 347 21 less less RBR cord-282610-zim7nond 347 22 recognized recognize VBN cord-282610-zim7nond 347 23 by by IN cord-282610-zim7nond 347 24 the the DT cord-282610-zim7nond 347 25 host host NN cord-282610-zim7nond 347 26 immune immune JJ cord-282610-zim7nond 347 27 system system NN cord-282610-zim7nond 347 28 . . . cord-282610-zim7nond 348 1 Or or CC cord-282610-zim7nond 348 2 , , , cord-282610-zim7nond 348 3 in in IN cord-282610-zim7nond 348 4 early early JJ cord-282610-zim7nond 348 5 - - HYPH cord-282610-zim7nond 348 6 stage stage NN cord-282610-zim7nond 348 7 ME ME NNP cord-282610-zim7nond 348 8 / / SYM cord-282610-zim7nond 348 9 CFS CFS NNP cord-282610-zim7nond 348 10 , , , cord-282610-zim7nond 348 11 the the DT cord-282610-zim7nond 348 12 immune immune JJ cord-282610-zim7nond 348 13 system system NN cord-282610-zim7nond 348 14 may may MD cord-282610-zim7nond 348 15 actively actively RB cord-282610-zim7nond 348 16 attempt attempt VB cord-282610-zim7nond 348 17 to to TO cord-282610-zim7nond 348 18 target target VB cord-282610-zim7nond 348 19 a a DT cord-282610-zim7nond 348 20 growing grow VBG cord-282610-zim7nond 348 21 infectious infectious JJ cord-282610-zim7nond 348 22 burden burden NN cord-282610-zim7nond 348 23 . . . cord-282610-zim7nond 349 1 Over over IN cord-282610-zim7nond 349 2 time time NN cord-282610-zim7nond 349 3 however however RB cord-282610-zim7nond 349 4 , , , cord-282610-zim7nond 349 5 pathogens pathogen NNS cord-282610-zim7nond 349 6 in in IN cord-282610-zim7nond 349 7 the the DT cord-282610-zim7nond 349 8 microbiome microbiome NN cord-282610-zim7nond 349 9 may may MD cord-282610-zim7nond 349 10 disable disable VB cord-282610-zim7nond 349 11 the the DT cord-282610-zim7nond 349 12 immune immune JJ cord-282610-zim7nond 349 13 response response NN cord-282610-zim7nond 349 14 to to IN cord-282610-zim7nond 349 15 a a DT cord-282610-zim7nond 349 16 point point NN cord-282610-zim7nond 349 17 where where WRB cord-282610-zim7nond 349 18 " " `` cord-282610-zim7nond 349 19 immune immune JJ cord-282610-zim7nond 349 20 exhaustion exhaustion NN cord-282610-zim7nond 349 21 " " '' cord-282610-zim7nond 349 22 occurs occur VBZ cord-282610-zim7nond 349 23 ( ( -LRB- cord-282610-zim7nond 349 24 136 136 CD cord-282610-zim7nond 349 25 , , , cord-282610-zim7nond 349 26 137 137 CD cord-282610-zim7nond 349 27 ) ) -RRB- cord-282610-zim7nond 349 28 . . . cord-282610-zim7nond 350 1 Immunopathology immunopathology NN cord-282610-zim7nond 350 2 and and CC cord-282610-zim7nond 350 3 cytokine cytokine NN cord-282610-zim7nond 350 4 production production NN cord-282610-zim7nond 350 5 would would MD cord-282610-zim7nond 350 6 subsequently subsequently RB cord-282610-zim7nond 350 7 drop drop VB cord-282610-zim7nond 350 8 . . . cord-282610-zim7nond 351 1 The the DT cord-282610-zim7nond 351 2 resulting result VBG cord-282610-zim7nond 351 3 disease disease NN cord-282610-zim7nond 351 4 state state NN cord-282610-zim7nond 351 5 could could MD cord-282610-zim7nond 351 6 be be VB cord-282610-zim7nond 351 7 compared compare VBN cord-282610-zim7nond 351 8 to to IN cord-282610-zim7nond 351 9 a a DT cord-282610-zim7nond 351 10 garden garden NN cord-282610-zim7nond 351 11 , , , cord-282610-zim7nond 351 12 in in IN cord-282610-zim7nond 351 13 which which WDT cord-282610-zim7nond 351 14 healthy healthy JJ cord-282610-zim7nond 351 15 plants plant NNS cord-282610-zim7nond 351 16 become become VBP cord-282610-zim7nond 351 17 progressively progressively RB cord-282610-zim7nond 351 18 stifled stifle VBN cord-282610-zim7nond 351 19 by by IN cord-282610-zim7nond 351 20 others other NNS cord-282610-zim7nond 351 21 , , , cord-282610-zim7nond 351 22 such such JJ cord-282610-zim7nond 351 23 as as IN cord-282610-zim7nond 351 24 kudzu kudzu NN cord-282610-zim7nond 351 25 vine vine NN cord-282610-zim7nond 351 26 . . . cord-282610-zim7nond 352 1 Many many JJ cord-282610-zim7nond 352 2 research research NN cord-282610-zim7nond 352 3 teams team NNS cord-282610-zim7nond 352 4 are be VBP cord-282610-zim7nond 352 5 studying study VBG cord-282610-zim7nond 352 6 how how WRB cord-282610-zim7nond 352 7 " " `` cord-282610-zim7nond 352 8 acute acute JJ cord-282610-zim7nond 352 9 " " '' cord-282610-zim7nond 352 10 pathogens pathogen NNS cord-282610-zim7nond 352 11 ( ( -LRB- cord-282610-zim7nond 352 12 i.e. i.e. FW cord-282610-zim7nond 352 13 , , , cord-282610-zim7nond 352 14 well well RB cord-282610-zim7nond 352 15 - - HYPH cord-282610-zim7nond 352 16 characterized characterize VBN cord-282610-zim7nond 352 17 agents agent NNS cord-282610-zim7nond 352 18 associated associate VBN cord-282610-zim7nond 352 19 with with IN cord-282610-zim7nond 352 20 known know VBN cord-282610-zim7nond 352 21 infectious infectious JJ cord-282610-zim7nond 352 22 diseases disease NNS cord-282610-zim7nond 352 23 ) ) -RRB- cord-282610-zim7nond 352 24 can can MD cord-282610-zim7nond 352 25 cause cause VB cord-282610-zim7nond 352 26 chronic chronic JJ cord-282610-zim7nond 352 27 symptoms symptom NNS cord-282610-zim7nond 352 28 by by IN cord-282610-zim7nond 352 29 persisting persist VBG cord-282610-zim7nond 352 30 in in IN cord-282610-zim7nond 352 31 latent latent JJ cord-282610-zim7nond 352 32 forms form NNS cord-282610-zim7nond 352 33 . . . cord-282610-zim7nond 353 1 These these DT cord-282610-zim7nond 353 2 include include VBP cord-282610-zim7nond 353 3 Zika Zika NNP cord-282610-zim7nond 353 4 , , , cord-282610-zim7nond 353 5 Borrelia Borrelia NNP cord-282610-zim7nond 353 6 burgdorferi burgdorferi NN cord-282610-zim7nond 353 7 , , , cord-282610-zim7nond 353 8 influenza influenza NN cord-282610-zim7nond 353 9 , , , cord-282610-zim7nond 353 10 and and CC cord-282610-zim7nond 353 11 other other JJ cord-282610-zim7nond 353 12 well well RB cord-282610-zim7nond 353 13 - - HYPH cord-282610-zim7nond 353 14 characterized characterize VBN cord-282610-zim7nond 353 15 viruses virus NNS cord-282610-zim7nond 353 16 and and CC cord-282610-zim7nond 353 17 bacteria bacteria NNS cord-282610-zim7nond 353 18 ( ( -LRB- cord-282610-zim7nond 353 19 138 138 CD cord-282610-zim7nond 353 20 ) ) -RRB- cord-282610-zim7nond 353 21 . . . cord-282610-zim7nond 354 1 Zika Zika NNP cord-282610-zim7nond 354 2 was be VBD cord-282610-zim7nond 354 3 shown show VBN cord-282610-zim7nond 354 4 capable capable JJ cord-282610-zim7nond 354 5 of of IN cord-282610-zim7nond 354 6 persisting persist VBG cord-282610-zim7nond 354 7 in in IN cord-282610-zim7nond 354 8 the the DT cord-282610-zim7nond 354 9 cerebrospinal cerebrospinal JJ cord-282610-zim7nond 354 10 fluid fluid NN cord-282610-zim7nond 354 11 ( ( -LRB- cord-282610-zim7nond 354 12 CSF CSF NNP cord-282610-zim7nond 354 13 ) ) -RRB- cord-282610-zim7nond 354 14 and and CC cord-282610-zim7nond 354 15 lymph lymph NN cord-282610-zim7nond 354 16 nodes node NNS cord-282610-zim7nond 354 17 of of IN cord-282610-zim7nond 354 18 infected infected JJ cord-282610-zim7nond 354 19 rhesus rhesu NNS cord-282610-zim7nond 354 20 monkeys monkey NNS cord-282610-zim7nond 354 21 for for IN cord-282610-zim7nond 354 22 months month NNS cord-282610-zim7nond 354 23 after after IN cord-282610-zim7nond 354 24 the the DT cord-282610-zim7nond 354 25 virus virus NN cord-282610-zim7nond 354 26 had have VBD cord-282610-zim7nond 354 27 been be VBN cord-282610-zim7nond 354 28 cleared clear VBN cord-282610-zim7nond 354 29 from from IN cord-282610-zim7nond 354 30 mucosal mucosal JJ cord-282610-zim7nond 354 31 secretions secretion NNS cord-282610-zim7nond 354 32 , , , cord-282610-zim7nond 354 33 peripheral peripheral JJ cord-282610-zim7nond 354 34 blood blood NN cord-282610-zim7nond 354 35 and and CC cord-282610-zim7nond 354 36 urine urine NN cord-282610-zim7nond 354 37 ( ( -LRB- cord-282610-zim7nond 354 38 139 139 CD cord-282610-zim7nond 354 39 ) ) -RRB- cord-282610-zim7nond 354 40 . . . cord-282610-zim7nond 355 1 Viral viral JJ cord-282610-zim7nond 355 2 persistence persistence NN cord-282610-zim7nond 355 3 in in IN cord-282610-zim7nond 355 4 both both CC cord-282610-zim7nond 355 5 the the DT cord-282610-zim7nond 355 6 lymph lymph NN cord-282610-zim7nond 355 7 nodes node NNS cord-282610-zim7nond 355 8 and and CC cord-282610-zim7nond 355 9 CSF CSF NNP cord-282610-zim7nond 355 10 was be VBD cord-282610-zim7nond 355 11 correlated correlate VBN cord-282610-zim7nond 355 12 with with IN cord-282610-zim7nond 355 13 upregulation upregulation NN cord-282610-zim7nond 355 14 of of IN cord-282610-zim7nond 355 15 genes gene NNS cord-282610-zim7nond 355 16 involved involve VBN cord-282610-zim7nond 355 17 in in IN cord-282610-zim7nond 355 18 pro pro JJ cord-282610-zim7nond 355 19 - - JJ cord-282610-zim7nond 355 20 inflammatory inflammatory JJ cord-282610-zim7nond 355 21 and and CC cord-282610-zim7nond 355 22 anti anti JJ cord-282610-zim7nond 355 23 - - JJ cord-282610-zim7nond 355 24 apoptotic apoptotic JJ cord-282610-zim7nond 355 25 pathways pathway NNS cord-282610-zim7nond 355 26 . . . cord-282610-zim7nond 356 1 Tens ten NNS cord-282610-zim7nond 356 2 of of IN cord-282610-zim7nond 356 3 thousands thousand NNS cord-282610-zim7nond 356 4 of of IN cord-282610-zim7nond 356 5 Ebola Ebola NNP cord-282610-zim7nond 356 6 survivors survivor NNS cord-282610-zim7nond 356 7 have have VBP cord-282610-zim7nond 356 8 developed develop VBN cord-282610-zim7nond 356 9 chronic chronic JJ cord-282610-zim7nond 356 10 symptoms symptom NNS cord-282610-zim7nond 356 11 months month NNS cord-282610-zim7nond 356 12 or or CC cord-282610-zim7nond 356 13 years year NNS cord-282610-zim7nond 356 14 after after IN cord-282610-zim7nond 356 15 initial initial JJ cord-282610-zim7nond 356 16 infection infection NN cord-282610-zim7nond 356 17 ( ( -LRB- cord-282610-zim7nond 356 18 140 140 CD cord-282610-zim7nond 356 19 ) ) -RRB- cord-282610-zim7nond 356 20 . . . cord-282610-zim7nond 357 1 These these DT cord-282610-zim7nond 357 2 " " `` cord-282610-zim7nond 357 3 Post Post NNP cord-282610-zim7nond 357 4 - - NNP cord-282610-zim7nond 357 5 Ebola Ebola NNP cord-282610-zim7nond 357 6 Syndrome Syndrome NNP cord-282610-zim7nond 357 7 " " '' cord-282610-zim7nond 357 8 symptoms symptom NNS cord-282610-zim7nond 357 9 include include VBP cord-282610-zim7nond 357 10 extreme extreme JJ cord-282610-zim7nond 357 11 fatigue fatigue NN cord-282610-zim7nond 357 12 , , , cord-282610-zim7nond 357 13 severe severe JJ cord-282610-zim7nond 357 14 pain pain NN cord-282610-zim7nond 357 15 , , , cord-282610-zim7nond 357 16 eye eye NN cord-282610-zim7nond 357 17 problems problem NNS cord-282610-zim7nond 357 18 , , , cord-282610-zim7nond 357 19 and and CC cord-282610-zim7nond 357 20 a a DT cord-282610-zim7nond 357 21 host host NN cord-282610-zim7nond 357 22 of of IN cord-282610-zim7nond 357 23 neurological neurological JJ cord-282610-zim7nond 357 24 issues issue NNS cord-282610-zim7nond 357 25 . . . cord-282610-zim7nond 358 1 While while IN cord-282610-zim7nond 358 2 the the DT cord-282610-zim7nond 358 3 virus virus NN cord-282610-zim7nond 358 4 is be VBZ cord-282610-zim7nond 358 5 hard hard JJ cord-282610-zim7nond 358 6 to to TO cord-282610-zim7nond 358 7 identify identify VB cord-282610-zim7nond 358 8 in in IN cord-282610-zim7nond 358 9 the the DT cord-282610-zim7nond 358 10 blood blood NN cord-282610-zim7nond 358 11 of of IN cord-282610-zim7nond 358 12 such such JJ cord-282610-zim7nond 358 13 patients patient NNS cord-282610-zim7nond 358 14 , , , cord-282610-zim7nond 358 15 Ebola Ebola NNP cord-282610-zim7nond 358 16 has have VBZ cord-282610-zim7nond 358 17 been be VBN cord-282610-zim7nond 358 18 detected detect VBN cord-282610-zim7nond 358 19 in in IN cord-282610-zim7nond 358 20 men man NNS cord-282610-zim7nond 358 21 's 's POS cord-282610-zim7nond 358 22 semen semen NN cord-282610-zim7nond 358 23 years year NNS cord-282610-zim7nond 358 24 after after IN cord-282610-zim7nond 358 25 " " `` cord-282610-zim7nond 358 26 recovery recovery NN cord-282610-zim7nond 358 27 " " '' cord-282610-zim7nond 358 28 ( ( -LRB- cord-282610-zim7nond 358 29 141 141 CD cord-282610-zim7nond 358 30 ) ) -RRB- cord-282610-zim7nond 358 31 . . . cord-282610-zim7nond 359 1 Another another DT cord-282610-zim7nond 359 2 study study NN cord-282610-zim7nond 359 3 found find VBD cord-282610-zim7nond 359 4 that that IN cord-282610-zim7nond 359 5 , , , cord-282610-zim7nond 359 6 up up IN cord-282610-zim7nond 359 7 to to IN cord-282610-zim7nond 359 8 a a DT cord-282610-zim7nond 359 9 month month NN cord-282610-zim7nond 359 10 after after IN cord-282610-zim7nond 359 11 initial initial JJ cord-282610-zim7nond 359 12 infection infection NN cord-282610-zim7nond 359 13 , , , cord-282610-zim7nond 359 14 influenza influenza NN cord-282610-zim7nond 359 15 viruses virus NNS cord-282610-zim7nond 359 16 regulated regulate VBD cord-282610-zim7nond 359 17 the the DT cord-282610-zim7nond 359 18 long long JJ cord-282610-zim7nond 359 19 - - HYPH cord-282610-zim7nond 359 20 term term NN cord-282610-zim7nond 359 21 expression expression NN cord-282610-zim7nond 359 22 of of IN cord-282610-zim7nond 359 23 inflammatory inflammatory JJ cord-282610-zim7nond 359 24 and and CC cord-282610-zim7nond 359 25 neuron neuron NN cord-282610-zim7nond 359 26 / / SYM cord-282610-zim7nond 359 27 glia glia NN cord-282610-zim7nond 359 28 - - HYPH cord-282610-zim7nond 359 29 specific specific JJ cord-282610-zim7nond 359 30 genes gene NNS cord-282610-zim7nond 359 31 in in IN cord-282610-zim7nond 359 32 mice mouse NNS cord-282610-zim7nond 359 33 ( ( -LRB- cord-282610-zim7nond 359 34 142 142 CD cord-282610-zim7nond 359 35 ) ) -RRB- cord-282610-zim7nond 359 36 . . . cord-282610-zim7nond 360 1 This this DT cord-282610-zim7nond 360 2 was be VBD cord-282610-zim7nond 360 3 associated associate VBN cord-282610-zim7nond 360 4 with with IN cord-282610-zim7nond 360 5 chronic chronic JJ cord-282610-zim7nond 360 6 neuroinflammation neuroinflammation NN cord-282610-zim7nond 360 7 characterized characterize VBN cord-282610-zim7nond 360 8 by by IN cord-282610-zim7nond 360 9 an an DT cord-282610-zim7nond 360 10 increase increase NN cord-282610-zim7nond 360 11 in in IN cord-282610-zim7nond 360 12 the the DT cord-282610-zim7nond 360 13 number number NN cord-282610-zim7nond 360 14 of of IN cord-282610-zim7nond 360 15 activated activate VBN cord-282610-zim7nond 360 16 microglia microglia NNS cord-282610-zim7nond 360 17 and and CC cord-282610-zim7nond 360 18 impairment impairment NN cord-282610-zim7nond 360 19 of of IN cord-282610-zim7nond 360 20 spatial spatial JJ cord-282610-zim7nond 360 21 memory memory NN cord-282610-zim7nond 360 22 formation formation NN cord-282610-zim7nond 360 23 . . . cord-282610-zim7nond 361 1 Persistent persistent JJ cord-282610-zim7nond 361 2 measles measle NNS cord-282610-zim7nond 361 3 virus virus NN cord-282610-zim7nond 361 4 is be VBZ cord-282610-zim7nond 361 5 associated associate VBN cord-282610-zim7nond 361 6 with with IN cord-282610-zim7nond 361 7 conditions condition NNS cord-282610-zim7nond 361 8 such such JJ cord-282610-zim7nond 361 9 as as IN cord-282610-zim7nond 361 10 Paget Paget NNP cord-282610-zim7nond 361 11 's 's POS cord-282610-zim7nond 361 12 disease disease NN cord-282610-zim7nond 361 13 , , , cord-282610-zim7nond 361 14 multiple multiple JJ cord-282610-zim7nond 361 15 sclerosis sclerosis NN cord-282610-zim7nond 361 16 and and CC cord-282610-zim7nond 361 17 Crohn Crohn NNP cord-282610-zim7nond 361 18 's 's POS cord-282610-zim7nond 361 19 disease disease NN cord-282610-zim7nond 361 20 ( ( -LRB- cord-282610-zim7nond 361 21 143 143 CD cord-282610-zim7nond 361 22 , , , cord-282610-zim7nond 361 23 144 144 CD cord-282610-zim7nond 361 24 ) ) -RRB- cord-282610-zim7nond 361 25 . . . cord-282610-zim7nond 362 1 Measles Measles NNP cord-282610-zim7nond 362 2 virus virus NN cord-282610-zim7nond 362 3 RNA RNA NNP cord-282610-zim7nond 362 4 has have VBZ cord-282610-zim7nond 362 5 been be VBN cord-282610-zim7nond 362 6 detected detect VBN cord-282610-zim7nond 362 7 in in IN cord-282610-zim7nond 362 8 blood blood NN cord-282610-zim7nond 362 9 , , , cord-282610-zim7nond 362 10 respiratory respiratory JJ cord-282610-zim7nond 362 11 secretions secretion NNS cord-282610-zim7nond 362 12 , , , cord-282610-zim7nond 362 13 urine urine NN cord-282610-zim7nond 362 14 , , , cord-282610-zim7nond 362 15 and and CC cord-282610-zim7nond 362 16 lymphoid lymphoid JJ cord-282610-zim7nond 362 17 tissue tissue NN cord-282610-zim7nond 362 18 for for IN cord-282610-zim7nond 362 19 weeks week NNS cord-282610-zim7nond 362 20 to to IN cord-282610-zim7nond 362 21 months month NNS cord-282610-zim7nond 362 22 after after IN cord-282610-zim7nond 362 23 clearance clearance NN cord-282610-zim7nond 362 24 of of IN cord-282610-zim7nond 362 25 the the DT cord-282610-zim7nond 362 26 " " `` cord-282610-zim7nond 362 27 acute acute JJ cord-282610-zim7nond 362 28 " " '' cord-282610-zim7nond 362 29 infection infection NN cord-282610-zim7nond 362 30 ( ( -LRB- cord-282610-zim7nond 362 31 145 145 CD cord-282610-zim7nond 362 32 ) ) -RRB- cord-282610-zim7nond 362 33 . . . cord-282610-zim7nond 363 1 Doi Doi NNP cord-282610-zim7nond 363 2 et et FW cord-282610-zim7nond 363 3 al al NNP cord-282610-zim7nond 363 4 . . . cord-282610-zim7nond 364 1 ( ( -LRB- cord-282610-zim7nond 364 2 146 146 CD cord-282610-zim7nond 364 3 ) ) -RRB- cord-282610-zim7nond 364 4 found find VBD cord-282610-zim7nond 364 5 that that IN cord-282610-zim7nond 364 6 , , , cord-282610-zim7nond 364 7 in in IN cord-282610-zim7nond 364 8 vitro vitro FW cord-282610-zim7nond 364 9 , , , cord-282610-zim7nond 364 10 measles measles NN cord-282610-zim7nond 364 11 virus virus NN cord-282610-zim7nond 364 12 persistence persistence NN cord-282610-zim7nond 364 13 correlated correlate VBN cord-282610-zim7nond 364 14 with with IN cord-282610-zim7nond 364 15 viral viral JJ cord-282610-zim7nond 364 16 transition transition NN cord-282610-zim7nond 364 17 from from IN cord-282610-zim7nond 364 18 a a DT cord-282610-zim7nond 364 19 lytic lytic JJ cord-282610-zim7nond 364 20 to to IN cord-282610-zim7nond 364 21 non non JJ cord-282610-zim7nond 364 22 - - JJ cord-282610-zim7nond 364 23 lytic lytic JJ cord-282610-zim7nond 364 24 mode mode NN cord-282610-zim7nond 364 25 that that WDT cord-282610-zim7nond 364 26 allowed allow VBD cord-282610-zim7nond 364 27 the the DT cord-282610-zim7nond 364 28 virus virus NN cord-282610-zim7nond 364 29 to to TO cord-282610-zim7nond 364 30 evade evade VB cord-282610-zim7nond 364 31 the the DT cord-282610-zim7nond 364 32 host host NN cord-282610-zim7nond 364 33 innate innate JJ cord-282610-zim7nond 364 34 immune immune JJ cord-282610-zim7nond 364 35 response response NN cord-282610-zim7nond 364 36 . . . cord-282610-zim7nond 365 1 Hundreds hundred NNS cord-282610-zim7nond 365 2 of of IN cord-282610-zim7nond 365 3 studies study NNS cord-282610-zim7nond 365 4 demonstrate demonstrate VBP cord-282610-zim7nond 365 5 that that IN cord-282610-zim7nond 365 6 acute acute JJ cord-282610-zim7nond 365 7 bacterial bacterial JJ cord-282610-zim7nond 365 8 pathogens pathogen NNS cord-282610-zim7nond 365 9 can can MD cord-282610-zim7nond 365 10 transition transition VB cord-282610-zim7nond 365 11 into into IN cord-282610-zim7nond 365 12 latent latent JJ cord-282610-zim7nond 365 13 forms form NNS cord-282610-zim7nond 365 14 that that WDT cord-282610-zim7nond 365 15 lack lack VBP cord-282610-zim7nond 365 16 a a DT cord-282610-zim7nond 365 17 classical classical JJ cord-282610-zim7nond 365 18 cell cell NN cord-282610-zim7nond 365 19 wall wall NN cord-282610-zim7nond 365 20 ( ( -LRB- cord-282610-zim7nond 365 21 1 1 CD cord-282610-zim7nond 365 22 ) ) -RRB- cord-282610-zim7nond 365 23 . . . cord-282610-zim7nond 366 1 These these DT cord-282610-zim7nond 366 2 persistent persistent JJ cord-282610-zim7nond 366 3 variants variant NNS cord-282610-zim7nond 366 4 are be VBP cord-282610-zim7nond 366 5 referred refer VBN cord-282610-zim7nond 366 6 to to IN cord-282610-zim7nond 366 7 as as IN cord-282610-zim7nond 366 8 L l NN cord-282610-zim7nond 366 9 - - HYPH cord-282610-zim7nond 366 10 form form NN cord-282610-zim7nond 366 11 bacteria bacteria NNS cord-282610-zim7nond 366 12 . . . cord-282610-zim7nond 367 1 Antibiotic antibiotic JJ cord-282610-zim7nond 367 2 use use NN cord-282610-zim7nond 367 3 can can MD cord-282610-zim7nond 367 4 induce induce VB cord-282610-zim7nond 367 5 persistent persistent JJ cord-282610-zim7nond 367 6 L l NN cord-282610-zim7nond 367 7 - - HYPH cord-282610-zim7nond 367 8 form form NN cord-282610-zim7nond 367 9 growth growth NN cord-282610-zim7nond 367 10 . . . cord-282610-zim7nond 368 1 In in IN cord-282610-zim7nond 368 2 fact fact NN cord-282610-zim7nond 368 3 , , , cord-282610-zim7nond 368 4 researchers researcher NNS cord-282610-zim7nond 368 5 create create VBP cord-282610-zim7nond 368 6 L l NN cord-282610-zim7nond 368 7 - - HYPH cord-282610-zim7nond 368 8 forms form NNS cord-282610-zim7nond 368 9 by by IN cord-282610-zim7nond 368 10 deliberately deliberately RB cord-282610-zim7nond 368 11 culturing culture VBG cord-282610-zim7nond 368 12 classical classical JJ cord-282610-zim7nond 368 13 bacteria bacteria NNS cord-282610-zim7nond 368 14 in in IN cord-282610-zim7nond 368 15 conjunction conjunction NN cord-282610-zim7nond 368 16 with with IN cord-282610-zim7nond 368 17 the the DT cord-282610-zim7nond 368 18 beta beta NN cord-282610-zim7nond 368 19 - - HYPH cord-282610-zim7nond 368 20 lactam lactam NN cord-282610-zim7nond 368 21 antibiotics antibiotic NNS cord-282610-zim7nond 368 22 ( ( -LRB- cord-282610-zim7nond 368 23 147 147 CD cord-282610-zim7nond 368 24 ) ) -RRB- cord-282610-zim7nond 368 25 . . . cord-282610-zim7nond 369 1 One one CD cord-282610-zim7nond 369 2 microarray microarray NN cord-282610-zim7nond 369 3 analysis analysis NN cord-282610-zim7nond 369 4 of of IN cord-282610-zim7nond 369 5 L l NN cord-282610-zim7nond 369 6 - - HYPH cord-282610-zim7nond 369 7 form form NN cord-282610-zim7nond 369 8 growth growth NN cord-282610-zim7nond 369 9 revealed reveal VBD cord-282610-zim7nond 369 10 upregulation upregulation NN cord-282610-zim7nond 369 11 of of IN cord-282610-zim7nond 369 12 genes gene NNS cord-282610-zim7nond 369 13 shared share VBN cord-282610-zim7nond 369 14 in in IN cord-282610-zim7nond 369 15 common common JJ cord-282610-zim7nond 369 16 with with IN cord-282610-zim7nond 369 17 persister persister NN cord-282610-zim7nond 369 18 cells cell NNS cord-282610-zim7nond 369 19 and and CC cord-282610-zim7nond 369 20 biofilms biofilm NNS cord-282610-zim7nond 369 21 ( ( -LRB- cord-282610-zim7nond 369 22 148 148 CD cord-282610-zim7nond 369 23 ) ) -RRB- cord-282610-zim7nond 369 24 . . . cord-282610-zim7nond 370 1 L l NN cord-282610-zim7nond 370 2 - - HYPH cord-282610-zim7nond 370 3 form form NN cord-282610-zim7nond 370 4 bacteria bacteria NNS cord-282610-zim7nond 370 5 have have VBP cord-282610-zim7nond 370 6 been be VBN cord-282610-zim7nond 370 7 implicated implicate VBN cord-282610-zim7nond 370 8 in in IN cord-282610-zim7nond 370 9 dozens dozen NNS cord-282610-zim7nond 370 10 of of IN cord-282610-zim7nond 370 11 chronic chronic JJ cord-282610-zim7nond 370 12 conditions condition NNS cord-282610-zim7nond 370 13 including include VBG cord-282610-zim7nond 370 14 rheumatoid rheumatoid NN cord-282610-zim7nond 370 15 arthritis arthritis NN cord-282610-zim7nond 370 16 , , , cord-282610-zim7nond 370 17 multiple multiple JJ cord-282610-zim7nond 370 18 sclerosis sclerosis NN cord-282610-zim7nond 370 19 and and CC cord-282610-zim7nond 370 20 sarcoidosis sarcoidosis NNP cord-282610-zim7nond 370 21 ( ( -LRB- cord-282610-zim7nond 370 22 1 1 CD cord-282610-zim7nond 370 23 , , , cord-282610-zim7nond 370 24 149 149 CD cord-282610-zim7nond 370 25 , , , cord-282610-zim7nond 370 26 150 150 CD cord-282610-zim7nond 370 27 ) ) -RRB- cord-282610-zim7nond 370 28 . . . cord-282610-zim7nond 371 1 A a DT cord-282610-zim7nond 371 2 better well JJR cord-282610-zim7nond 371 3 understanding understanding NN cord-282610-zim7nond 371 4 of of IN cord-282610-zim7nond 371 5 these these DT cord-282610-zim7nond 371 6 chronic chronic JJ cord-282610-zim7nond 371 7 sequelae sequela NNS cord-282610-zim7nond 371 8 would would MD cord-282610-zim7nond 371 9 greatly greatly RB cord-282610-zim7nond 371 10 benefit benefit VB cord-282610-zim7nond 371 11 the the DT cord-282610-zim7nond 371 12 ME ME NNP cord-282610-zim7nond 371 13 / / SYM cord-282610-zim7nond 371 14 CFS CFS NNP cord-282610-zim7nond 371 15 community community NN cord-282610-zim7nond 371 16 , , , cord-282610-zim7nond 371 17 since since IN cord-282610-zim7nond 371 18 a a DT cord-282610-zim7nond 371 19 similar similar JJ cord-282610-zim7nond 371 20 chronic chronic JJ cord-282610-zim7nond 371 21 progression progression NN cord-282610-zim7nond 371 22 of of IN cord-282610-zim7nond 371 23 symptoms symptom NNS cord-282610-zim7nond 371 24 is be VBZ cord-282610-zim7nond 371 25 frequently frequently RB cord-282610-zim7nond 371 26 documented document VBN cord-282610-zim7nond 371 27 in in IN cord-282610-zim7nond 371 28 ME ME NNP cord-282610-zim7nond 371 29 / / SYM cord-282610-zim7nond 371 30 CFS CFS NNP cord-282610-zim7nond 371 31 . . . cord-282610-zim7nond 372 1 At at IN cord-282610-zim7nond 372 2 different different JJ cord-282610-zim7nond 372 3 points point NNS cord-282610-zim7nond 372 4 in in IN cord-282610-zim7nond 372 5 history history NN cord-282610-zim7nond 372 6 , , , cord-282610-zim7nond 372 7 ME ME NNP cord-282610-zim7nond 372 8 / / SYM cord-282610-zim7nond 372 9 CFS CFS NNP cord-282610-zim7nond 372 10 has have VBZ cord-282610-zim7nond 372 11 been be VBN cord-282610-zim7nond 372 12 called call VBN cord-282610-zim7nond 372 13 " " `` cord-282610-zim7nond 372 14 Post Post NNP cord-282610-zim7nond 372 15 - - NNP cord-282610-zim7nond 372 16 Polio Polio NNP cord-282610-zim7nond 372 17 Syndrome Syndrome NNP cord-282610-zim7nond 372 18 , , , cord-282610-zim7nond 372 19 " " '' cord-282610-zim7nond 372 20 " " `` cord-282610-zim7nond 372 21 Chronic Chronic NNP cord-282610-zim7nond 372 22 Mononucleosis Mononucleosis NNP cord-282610-zim7nond 372 23 Syndrome Syndrome NNP cord-282610-zim7nond 372 24 " " '' cord-282610-zim7nond 372 25 and and CC cord-282610-zim7nond 372 26 " " `` cord-282610-zim7nond 372 27 Post post JJ cord-282610-zim7nond 372 28 - - JJ cord-282610-zim7nond 372 29 Viral viral JJ cord-282610-zim7nond 372 30 Syndrome Syndrome NNP cord-282610-zim7nond 372 31 " " '' cord-282610-zim7nond 372 32 due due JJ cord-282610-zim7nond 372 33 to to IN cord-282610-zim7nond 372 34 the the DT cord-282610-zim7nond 372 35 fact fact NN cord-282610-zim7nond 372 36 that that IN cord-282610-zim7nond 372 37 chronic chronic JJ cord-282610-zim7nond 372 38 symptoms symptom NNS cord-282610-zim7nond 372 39 are be VBP cord-282610-zim7nond 372 40 often often RB cord-282610-zim7nond 372 41 noted note VBN cord-282610-zim7nond 372 42 after after IN cord-282610-zim7nond 372 43 acute acute JJ cord-282610-zim7nond 372 44 infection infection NN cord-282610-zim7nond 372 45 with with IN cord-282610-zim7nond 372 46 Polio Polio NNP cord-282610-zim7nond 372 47 Virus Virus NNP cord-282610-zim7nond 372 48 , , , cord-282610-zim7nond 372 49 Epstein Epstein NNP cord-282610-zim7nond 372 50 Barr Barr NNP cord-282610-zim7nond 372 51 Virus Virus NNP cord-282610-zim7nond 372 52 , , , cord-282610-zim7nond 372 53 influenza influenza NN cord-282610-zim7nond 372 54 or or CC cord-282610-zim7nond 372 55 a a DT cord-282610-zim7nond 372 56 range range NN cord-282610-zim7nond 372 57 of of IN cord-282610-zim7nond 372 58 other other JJ cord-282610-zim7nond 372 59 pathogens pathogen NNS cord-282610-zim7nond 372 60 ( ( -LRB- cord-282610-zim7nond 372 61 151 151 CD cord-282610-zim7nond 372 62 ) ) -RRB- cord-282610-zim7nond 372 63 ( ( -LRB- cord-282610-zim7nond 372 64 152 152 CD cord-282610-zim7nond 372 65 ) ) -RRB- cord-282610-zim7nond 372 66 ( ( -LRB- cord-282610-zim7nond 372 67 153 153 CD cord-282610-zim7nond 372 68 ) ) -RRB- cord-282610-zim7nond 372 69 . . . cord-282610-zim7nond 373 1 Chia Chia NNP cord-282610-zim7nond 373 2 et et NNP cord-282610-zim7nond 373 3 al al NNP cord-282610-zim7nond 373 4 . . . cord-282610-zim7nond 374 1 ( ( -LRB- cord-282610-zim7nond 374 2 154 154 CD cord-282610-zim7nond 374 3 ) ) -RRB- cord-282610-zim7nond 374 4 found find VBD cord-282610-zim7nond 374 5 that that IN cord-282610-zim7nond 374 6 patients patient NNS cord-282610-zim7nond 374 7 with with IN cord-282610-zim7nond 374 8 acute acute JJ cord-282610-zim7nond 374 9 enterovirus enterovirus NN cord-282610-zim7nond 374 10 infection infection NN cord-282610-zim7nond 374 11 went go VBD cord-282610-zim7nond 374 12 on on RP cord-282610-zim7nond 374 13 to to TO cord-282610-zim7nond 374 14 develop develop VB cord-282610-zim7nond 374 15 a a DT cord-282610-zim7nond 374 16 multitude multitude NN cord-282610-zim7nond 374 17 of of IN cord-282610-zim7nond 374 18 chronic chronic JJ cord-282610-zim7nond 374 19 symptoms symptom NNS cord-282610-zim7nond 374 20 consistent consistent JJ cord-282610-zim7nond 374 21 with with IN cord-282610-zim7nond 374 22 an an DT cord-282610-zim7nond 374 23 ME ME NNP cord-282610-zim7nond 374 24 / / SYM cord-282610-zim7nond 374 25 CFS CFS NNP cord-282610-zim7nond 374 26 diagnosis diagnosis NN cord-282610-zim7nond 374 27 . . . cord-282610-zim7nond 375 1 Years year NNS cord-282610-zim7nond 375 2 after after IN cord-282610-zim7nond 375 3 the the DT cord-282610-zim7nond 375 4 initial initial JJ cord-282610-zim7nond 375 5 infection infection NN cord-282610-zim7nond 375 6 , , , cord-282610-zim7nond 375 7 enterovirus enterovirus NN cord-282610-zim7nond 375 8 protein protein NN cord-282610-zim7nond 375 9 and and CC cord-282610-zim7nond 375 10 RNA RNA NNP cord-282610-zim7nond 375 11 were be VBD cord-282610-zim7nond 375 12 still still RB cord-282610-zim7nond 375 13 present present JJ cord-282610-zim7nond 375 14 in in IN cord-282610-zim7nond 375 15 these these DT cord-282610-zim7nond 375 16 patients patient NNS cord-282610-zim7nond 375 17 ' ' POS cord-282610-zim7nond 375 18 stomach stomach NN cord-282610-zim7nond 375 19 biopsies biopsy NNS cord-282610-zim7nond 375 20 . . . cord-282610-zim7nond 376 1 It -PRON- PRP cord-282610-zim7nond 376 2 is be VBZ cord-282610-zim7nond 376 3 clear clear JJ cord-282610-zim7nond 376 4 that that IN cord-282610-zim7nond 376 5 novel novel JJ cord-282610-zim7nond 376 6 methodologies methodology NNS cord-282610-zim7nond 376 7 may may MD cord-282610-zim7nond 376 8 be be VB cord-282610-zim7nond 376 9 required require VBN cord-282610-zim7nond 376 10 to to TO cord-282610-zim7nond 376 11 best best RB cord-282610-zim7nond 376 12 identify identify VB cord-282610-zim7nond 376 13 pathogens pathogen NNS cord-282610-zim7nond 376 14 in in IN cord-282610-zim7nond 376 15 their -PRON- PRP$ cord-282610-zim7nond 376 16 latent latent JJ cord-282610-zim7nond 376 17 forms form NNS cord-282610-zim7nond 376 18 . . . cord-282610-zim7nond 377 1 Pathogens pathogen NNS cord-282610-zim7nond 377 2 that that WDT cord-282610-zim7nond 377 3 persist persist VBP cord-282610-zim7nond 377 4 inside inside IN cord-282610-zim7nond 377 5 human human JJ cord-282610-zim7nond 377 6 immune immune JJ cord-282610-zim7nond 377 7 cells cell NNS cord-282610-zim7nond 377 8 and and CC cord-282610-zim7nond 377 9 associated associate VBN cord-282610-zim7nond 377 10 tunneling tunnel VBG cord-282610-zim7nond 377 11 nanotubuoles nanotubuole NNS cord-282610-zim7nond 377 12 have have VBP cord-282610-zim7nond 377 13 been be VBN cord-282610-zim7nond 377 14 particularly particularly RB cord-282610-zim7nond 377 15 hard hard JJ cord-282610-zim7nond 377 16 to to TO cord-282610-zim7nond 377 17 detect detect VB cord-282610-zim7nond 377 18 . . . cord-282610-zim7nond 378 1 When when WRB cord-282610-zim7nond 378 2 persistent persistent JJ cord-282610-zim7nond 378 3 Zika Zika NNP cord-282610-zim7nond 378 4 virus virus NN cord-282610-zim7nond 378 5 was be VBD cord-282610-zim7nond 378 6 identified identify VBN cord-282610-zim7nond 378 7 in in IN cord-282610-zim7nond 378 8 rhesus rhesu NNS cord-282610-zim7nond 378 9 monkeys monkey NNS cord-282610-zim7nond 378 10 , , , cord-282610-zim7nond 378 11 Zikaspecific Zikaspecific NNP cord-282610-zim7nond 378 12 antibodies antibody NNS cord-282610-zim7nond 378 13 were be VBD cord-282610-zim7nond 378 14 not not RB cord-282610-zim7nond 378 15 detected detect VBN cord-282610-zim7nond 378 16 in in IN cord-282610-zim7nond 378 17 the the DT cord-282610-zim7nond 378 18 CSF CSF NNP cord-282610-zim7nond 378 19 , , , cord-282610-zim7nond 378 20 despite despite IN cord-282610-zim7nond 378 21 prolonged prolonged JJ cord-282610-zim7nond 378 22 and and CC cord-282610-zim7nond 378 23 robust robust JJ cord-282610-zim7nond 378 24 responses response NNS cord-282610-zim7nond 378 25 in in IN cord-282610-zim7nond 378 26 peripheral peripheral JJ cord-282610-zim7nond 378 27 blood blood NN cord-282610-zim7nond 378 28 . . . cord-282610-zim7nond 379 1 This this DT cord-282610-zim7nond 379 2 suggested suggest VBD cord-282610-zim7nond 379 3 an an DT cord-282610-zim7nond 379 4 additional additional JJ cord-282610-zim7nond 379 5 mechanism mechanism NN cord-282610-zim7nond 379 6 for for IN cord-282610-zim7nond 379 7 viral viral JJ cord-282610-zim7nond 379 8 persistence persistence NN cord-282610-zim7nond 379 9 in in IN cord-282610-zim7nond 379 10 certain certain JJ cord-282610-zim7nond 379 11 " " `` cord-282610-zim7nond 379 12 anotomic anotomic JJ cord-282610-zim7nond 379 13 sanctuaries sanctuary NNS cord-282610-zim7nond 379 14 . . . cord-282610-zim7nond 380 1 " " `` cord-282610-zim7nond 380 2 Modern modern JJ cord-282610-zim7nond 380 3 living living NN cord-282610-zim7nond 380 4 has have VBZ cord-282610-zim7nond 380 5 also also RB cord-282610-zim7nond 380 6 increased increase VBN cord-282610-zim7nond 380 7 the the DT cord-282610-zim7nond 380 8 likelihood likelihood NN cord-282610-zim7nond 380 9 that that IN cord-282610-zim7nond 380 10 " " `` cord-282610-zim7nond 380 11 acute acute JJ cord-282610-zim7nond 380 12 " " '' cord-282610-zim7nond 380 13 infections infection NNS cord-282610-zim7nond 380 14 may may MD cord-282610-zim7nond 380 15 generate generate VB cord-282610-zim7nond 380 16 chronic chronic JJ cord-282610-zim7nond 380 17 sequelae sequela NNS cord-282610-zim7nond 380 18 . . . cord-282610-zim7nond 381 1 Before before IN cord-282610-zim7nond 381 2 the the DT cord-282610-zim7nond 381 3 advent advent NN cord-282610-zim7nond 381 4 of of IN cord-282610-zim7nond 381 5 antibiotics antibiotic NNS cord-282610-zim7nond 381 6 , , , cord-282610-zim7nond 381 7 steroid steroid NN cord-282610-zim7nond 381 8 medications medication NNS cord-282610-zim7nond 381 9 and and CC cord-282610-zim7nond 381 10 childhood childhood NN cord-282610-zim7nond 381 11 vaccines vaccine NNS cord-282610-zim7nond 381 12 , , , cord-282610-zim7nond 381 13 almost almost RB cord-282610-zim7nond 381 14 half half NN cord-282610-zim7nond 381 15 of of IN cord-282610-zim7nond 381 16 all all DT cord-282610-zim7nond 381 17 children child NNS cord-282610-zim7nond 381 18 under under IN cord-282610-zim7nond 381 19 the the DT cord-282610-zim7nond 381 20 age age NN cord-282610-zim7nond 381 21 of of IN cord-282610-zim7nond 381 22 five five CD cord-282610-zim7nond 381 23 died die VBD cord-282610-zim7nond 381 24 from from IN cord-282610-zim7nond 381 25 acute acute JJ cord-282610-zim7nond 381 26 infectious infectious JJ cord-282610-zim7nond 381 27 disease disease NN cord-282610-zim7nond 381 28 ( ( -LRB- cord-282610-zim7nond 381 29 45 45 CD cord-282610-zim7nond 381 30 ) ) -RRB- cord-282610-zim7nond 381 31 . . . cord-282610-zim7nond 382 1 Today today NN cord-282610-zim7nond 382 2 , , , cord-282610-zim7nond 382 3 most most JJS cord-282610-zim7nond 382 4 individuals individual NNS cord-282610-zim7nond 382 5 in in IN cord-282610-zim7nond 382 6 first first JJ cord-282610-zim7nond 382 7 - - HYPH cord-282610-zim7nond 382 8 world world NN cord-282610-zim7nond 382 9 countries country NNS cord-282610-zim7nond 382 10 survive survive VBP cord-282610-zim7nond 382 11 repeated repeat VBN cord-282610-zim7nond 382 12 acute acute JJ cord-282610-zim7nond 382 13 infections infection NNS cord-282610-zim7nond 382 14 over over IN cord-282610-zim7nond 382 15 the the DT cord-282610-zim7nond 382 16 course course NN cord-282610-zim7nond 382 17 of of IN cord-282610-zim7nond 382 18 decades decade NNS cord-282610-zim7nond 382 19 . . . cord-282610-zim7nond 383 1 While while IN cord-282610-zim7nond 383 2 certain certain JJ cord-282610-zim7nond 383 3 dominant dominant JJ cord-282610-zim7nond 383 4 or or CC cord-282610-zim7nond 383 5 keystone keystone JJ cord-282610-zim7nond 383 6 pathogens pathogen NNS cord-282610-zim7nond 383 7 may may MD cord-282610-zim7nond 383 8 be be VB cord-282610-zim7nond 383 9 reliably reliably RB cord-282610-zim7nond 383 10 identified identify VBN cord-282610-zim7nond 383 11 in in IN cord-282610-zim7nond 383 12 patients patient NNS cord-282610-zim7nond 383 13 with with IN cord-282610-zim7nond 383 14 ME ME NNP cord-282610-zim7nond 383 15 / / SYM cord-282610-zim7nond 383 16 CFS CFS NNP cord-282610-zim7nond 383 17 , , , cord-282610-zim7nond 383 18 composition composition NN cord-282610-zim7nond 383 19 of of IN cord-282610-zim7nond 383 20 the the DT cord-282610-zim7nond 383 21 ME ME NNP cord-282610-zim7nond 383 22 / / SYM cord-282610-zim7nond 383 23 CFS CFS NNP cord-282610-zim7nond 383 24 microbiome microbiome NN cord-282610-zim7nond 383 25 will will MD cord-282610-zim7nond 383 26 likely likely RB cord-282610-zim7nond 383 27 differ differ VB cord-282610-zim7nond 383 28 between between IN cord-282610-zim7nond 383 29 patients patient NNS cord-282610-zim7nond 383 30 . . . cord-282610-zim7nond 384 1 Even even RB cord-282610-zim7nond 384 2 in in IN cord-282610-zim7nond 384 3 HIV HIV NNP cord-282610-zim7nond 384 4 / / SYM cord-282610-zim7nond 384 5 AIDS AIDS NNP cord-282610-zim7nond 384 6 , , , cord-282610-zim7nond 384 7 where where WRB cord-282610-zim7nond 384 8 an an DT cord-282610-zim7nond 384 9 easily easily RB cord-282610-zim7nond 384 10 detected detect VBN cord-282610-zim7nond 384 11 virus virus NN cord-282610-zim7nond 384 12 dysregulates dysregulate NNS cord-282610-zim7nond 384 13 immunity immunity NN cord-282610-zim7nond 384 14 , , , cord-282610-zim7nond 384 15 disease disease NN cord-282610-zim7nond 384 16 symptoms symptom NNS cord-282610-zim7nond 384 17 reflect reflect VBP cord-282610-zim7nond 384 18 a a DT cord-282610-zim7nond 384 19 mix mix NN cord-282610-zim7nond 384 20 of of IN cord-282610-zim7nond 384 21 those those DT cord-282610-zim7nond 384 22 driven drive VBN cord-282610-zim7nond 384 23 by by IN cord-282610-zim7nond 384 24 HIV HIV NNP cord-282610-zim7nond 384 25 , , , cord-282610-zim7nond 384 26 and and CC cord-282610-zim7nond 384 27 those those DT cord-282610-zim7nond 384 28 driven drive VBN cord-282610-zim7nond 384 29 by by IN cord-282610-zim7nond 384 30 " " `` cord-282610-zim7nond 384 31 co co JJ cord-282610-zim7nond 384 32 - - JJ cord-282610-zim7nond 384 33 infectious infectious JJ cord-282610-zim7nond 384 34 " " '' cord-282610-zim7nond 384 35 agents agent NNS cord-282610-zim7nond 384 36 able able JJ cord-282610-zim7nond 384 37 to to TO cord-282610-zim7nond 384 38 take take VB cord-282610-zim7nond 384 39 advantage advantage NN cord-282610-zim7nond 384 40 of of IN cord-282610-zim7nond 384 41 the the DT cord-282610-zim7nond 384 42 immunocompromised immunocompromised JJ cord-282610-zim7nond 384 43 host host NN cord-282610-zim7nond 384 44 ( ( -LRB- cord-282610-zim7nond 384 45 155 155 CD cord-282610-zim7nond 384 46 ) ) -RRB- cord-282610-zim7nond 384 47 . . . cord-282610-zim7nond 385 1 No no DT cord-282610-zim7nond 385 2 two two CD cord-282610-zim7nond 385 3 patients patient NNS cord-282610-zim7nond 385 4 with with IN cord-282610-zim7nond 385 5 HIV HIV NNP cord-282610-zim7nond 385 6 / / SYM cord-282610-zim7nond 385 7 AIDS AIDS NNP cord-282610-zim7nond 385 8 are be VBP cord-282610-zim7nond 385 9 expected expect VBN cord-282610-zim7nond 385 10 to to TO cord-282610-zim7nond 385 11 harbor harbor VB cord-282610-zim7nond 385 12 the the DT cord-282610-zim7nond 385 13 same same JJ cord-282610-zim7nond 385 14 mix mix NN cord-282610-zim7nond 385 15 of of IN cord-282610-zim7nond 385 16 these these DT cord-282610-zim7nond 385 17 additional additional JJ cord-282610-zim7nond 385 18 persistent persistent JJ cord-282610-zim7nond 385 19 bacteria bacteria NNS cord-282610-zim7nond 385 20 , , , cord-282610-zim7nond 385 21 fungi fungus NNS cord-282610-zim7nond 385 22 , , , cord-282610-zim7nond 385 23 and and CC cord-282610-zim7nond 385 24 viruses virus NNS cord-282610-zim7nond 385 25 . . . cord-282610-zim7nond 386 1 The the DT cord-282610-zim7nond 386 2 same same JJ cord-282610-zim7nond 386 3 is be VBZ cord-282610-zim7nond 386 4 true true JJ cord-282610-zim7nond 386 5 of of IN cord-282610-zim7nond 386 6 most most JJS cord-282610-zim7nond 386 7 cancers cancer NNS cord-282610-zim7nond 386 8 , , , cord-282610-zim7nond 386 9 an an DT cord-282610-zim7nond 386 10 increasing increase VBG cord-282610-zim7nond 386 11 number number NN cord-282610-zim7nond 386 12 of of IN cord-282610-zim7nond 386 13 which which WDT cord-282610-zim7nond 386 14 are be VBP cord-282610-zim7nond 386 15 now now RB cord-282610-zim7nond 386 16 tied tie VBN cord-282610-zim7nond 386 17 to to IN cord-282610-zim7nond 386 18 severe severe JJ cord-282610-zim7nond 386 19 microbiome microbiome NN cord-282610-zim7nond 386 20 dysbiosis dysbiosis NN cord-282610-zim7nond 386 21 ( ( -LRB- cord-282610-zim7nond 386 22 34 34 CD cord-282610-zim7nond 386 23 ) ) -RRB- cord-282610-zim7nond 386 24 . . . cord-282610-zim7nond 387 1 It -PRON- PRP cord-282610-zim7nond 387 2 is be VBZ cord-282610-zim7nond 387 3 widely widely RB cord-282610-zim7nond 387 4 accepted accept VBN cord-282610-zim7nond 387 5 that that IN cord-282610-zim7nond 387 6 no no DT cord-282610-zim7nond 387 7 two two CD cord-282610-zim7nond 387 8 cancers cancer NNS cord-282610-zim7nond 387 9 are be VBP cord-282610-zim7nond 387 10 alike alike RB cord-282610-zim7nond 387 11 , , , cord-282610-zim7nond 387 12 and and CC cord-282610-zim7nond 387 13 any any DT cord-282610-zim7nond 387 14 tumor tumor NN cord-282610-zim7nond 387 15 - - HYPH cord-282610-zim7nond 387 16 associated associate VBN cord-282610-zim7nond 387 17 microbiome microbiome NN cord-282610-zim7nond 387 18 is be VBZ cord-282610-zim7nond 387 19 expected expect VBN cord-282610-zim7nond 387 20 to to TO cord-282610-zim7nond 387 21 differ differ VB cord-282610-zim7nond 387 22 somewhat somewhat RB cord-282610-zim7nond 387 23 among among IN cord-282610-zim7nond 387 24 individual individual JJ cord-282610-zim7nond 387 25 study study NN cord-282610-zim7nond 387 26 subjects subject NNS cord-282610-zim7nond 387 27 ( ( -LRB- cord-282610-zim7nond 387 28 156 156 CD cord-282610-zim7nond 387 29 ) ) -RRB- cord-282610-zim7nond 387 30 . . . cord-282610-zim7nond 388 1 This this DT cord-282610-zim7nond 388 2 same same JJ cord-282610-zim7nond 388 3 pattern pattern NN cord-282610-zim7nond 388 4 , , , cord-282610-zim7nond 388 5 in in IN cord-282610-zim7nond 388 6 which which WDT cord-282610-zim7nond 388 7 unique unique JJ cord-282610-zim7nond 388 8 infectious infectious JJ cord-282610-zim7nond 388 9 history history NN cord-282610-zim7nond 388 10 impacts impact NNS cord-282610-zim7nond 388 11 symptom symptom NN cord-282610-zim7nond 388 12 presentation presentation NN cord-282610-zim7nond 388 13 may may MD cord-282610-zim7nond 388 14 also also RB cord-282610-zim7nond 388 15 occur occur VB cord-282610-zim7nond 388 16 in in IN cord-282610-zim7nond 388 17 ME ME NNP cord-282610-zim7nond 388 18 / / SYM cord-282610-zim7nond 388 19 CFS CFS NNP cord-282610-zim7nond 388 20 . . . cord-282610-zim7nond 389 1 A a DT cord-282610-zim7nond 389 2 recent recent JJ cord-282610-zim7nond 389 3 study study NN cord-282610-zim7nond 389 4 by by IN cord-282610-zim7nond 389 5 Brodin Brodin NNP cord-282610-zim7nond 389 6 et et NNP cord-282610-zim7nond 389 7 al al NNP cord-282610-zim7nond 389 8 . . . cord-282610-zim7nond 390 1 ( ( -LRB- cord-282610-zim7nond 390 2 45 45 CD cord-282610-zim7nond 390 3 ) ) -RRB- cord-282610-zim7nond 390 4 demonstrated demonstrate VBD cord-282610-zim7nond 390 5 the the DT cord-282610-zim7nond 390 6 profound profound JJ cord-282610-zim7nond 390 7 impact impact NN cord-282610-zim7nond 390 8 of of IN cord-282610-zim7nond 390 9 infectious infectious JJ cord-282610-zim7nond 390 10 history history NN cord-282610-zim7nond 390 11 on on IN cord-282610-zim7nond 390 12 host host NN cord-282610-zim7nond 390 13 immunity immunity NN cord-282610-zim7nond 390 14 . . . cord-282610-zim7nond 391 1 The the DT cord-282610-zim7nond 391 2 team team NN cord-282610-zim7nond 391 3 performed perform VBD cord-282610-zim7nond 391 4 a a DT cord-282610-zim7nond 391 5 systems system NNS cord-282610-zim7nond 391 6 - - HYPH cord-282610-zim7nond 391 7 level level NN cord-282610-zim7nond 391 8 analysis analysis NN cord-282610-zim7nond 391 9 of of IN cord-282610-zim7nond 391 10 210 210 CD cord-282610-zim7nond 391 11 healthy healthy JJ cord-282610-zim7nond 391 12 twins twin NNS cord-282610-zim7nond 391 13 between between IN cord-282610-zim7nond 391 14 the the DT cord-282610-zim7nond 391 15 ages age NNS cord-282610-zim7nond 391 16 of of IN cord-282610-zim7nond 391 17 8 8 CD cord-282610-zim7nond 391 18 and and CC cord-282610-zim7nond 391 19 82 82 CD cord-282610-zim7nond 391 20 . . . cord-282610-zim7nond 392 1 They -PRON- PRP cord-282610-zim7nond 392 2 measured measure VBD cord-282610-zim7nond 392 3 204 204 CD cord-282610-zim7nond 392 4 immune immune JJ cord-282610-zim7nond 392 5 parameters parameter NNS cord-282610-zim7nond 392 6 , , , cord-282610-zim7nond 392 7 including include VBG cord-282610-zim7nond 392 8 cell cell NN cord-282610-zim7nond 392 9 population population NN cord-282610-zim7nond 392 10 frequencies frequency NNS cord-282610-zim7nond 392 11 , , , cord-282610-zim7nond 392 12 cytokine cytokine NN cord-282610-zim7nond 392 13 responses response NNS cord-282610-zim7nond 392 14 , , , cord-282610-zim7nond 392 15 and and CC cord-282610-zim7nond 392 16 serum serum NN cord-282610-zim7nond 392 17 proteins protein NNS cord-282610-zim7nond 392 18 , , , cord-282610-zim7nond 392 19 and and CC cord-282610-zim7nond 392 20 found find VBD cord-282610-zim7nond 392 21 that that IN cord-282610-zim7nond 392 22 77 77 CD cord-282610-zim7nond 392 23 % % NN cord-282610-zim7nond 392 24 of of IN cord-282610-zim7nond 392 25 these these DT cord-282610-zim7nond 392 26 are be VBP cord-282610-zim7nond 392 27 dominated dominate VBN cord-282610-zim7nond 392 28 , , , cord-282610-zim7nond 392 29 and and CC cord-282610-zim7nond 392 30 58 58 CD cord-282610-zim7nond 392 31 % % NN cord-282610-zim7nond 392 32 almost almost RB cord-282610-zim7nond 392 33 completely completely RB cord-282610-zim7nond 392 34 determined determined JJ cord-282610-zim7nond 392 35 , , , cord-282610-zim7nond 392 36 by by IN cord-282610-zim7nond 392 37 non non JJ cord-282610-zim7nond 392 38 - - JJ cord-282610-zim7nond 392 39 heritable heritable JJ cord-282610-zim7nond 392 40 environmental environmental JJ cord-282610-zim7nond 392 41 influences influence NNS cord-282610-zim7nond 392 42 . . . cord-282610-zim7nond 393 1 Many many JJ cord-282610-zim7nond 393 2 of of IN cord-282610-zim7nond 393 3 these these DT cord-282610-zim7nond 393 4 parameters parameter NNS cord-282610-zim7nond 393 5 became become VBD cord-282610-zim7nond 393 6 more more RBR cord-282610-zim7nond 393 7 variable variable JJ cord-282610-zim7nond 393 8 with with IN cord-282610-zim7nond 393 9 age age NN cord-282610-zim7nond 393 10 , , , cord-282610-zim7nond 393 11 emphasizing emphasize VBG cord-282610-zim7nond 393 12 the the DT cord-282610-zim7nond 393 13 cumulative cumulative JJ cord-282610-zim7nond 393 14 influence influence NN cord-282610-zim7nond 393 15 of of IN cord-282610-zim7nond 393 16 environmental environmental JJ cord-282610-zim7nond 393 17 exposure exposure NN cord-282610-zim7nond 393 18 . . . cord-282610-zim7nond 394 1 The the DT cord-282610-zim7nond 394 2 team team NN cord-282610-zim7nond 394 3 also also RB cord-282610-zim7nond 394 4 calculated calculate VBD cord-282610-zim7nond 394 5 how how WRB cord-282610-zim7nond 394 6 acquisition acquisition NN cord-282610-zim7nond 394 7 of of IN cord-282610-zim7nond 394 8 just just RB cord-282610-zim7nond 394 9 one one CD cord-282610-zim7nond 394 10 chronic chronic JJ cord-282610-zim7nond 394 11 pathogen pathogen NN cord-282610-zim7nond 394 12 - - HYPH cord-282610-zim7nond 394 13 cytomegalovirus cytomegalovirus NN cord-282610-zim7nond 394 14 ( ( -LRB- cord-282610-zim7nond 394 15 CMV)-conditions cmv)-condition NNS cord-282610-zim7nond 394 16 the the DT cord-282610-zim7nond 394 17 immune immune JJ cord-282610-zim7nond 394 18 response response NN cord-282610-zim7nond 394 19 . . . cord-282610-zim7nond 395 1 Identical identical JJ cord-282610-zim7nond 395 2 twins twin NNS cord-282610-zim7nond 395 3 discordant discordant JJ cord-282610-zim7nond 395 4 for for IN cord-282610-zim7nond 395 5 CMV CMV NNP cord-282610-zim7nond 395 6 infection infection NN cord-282610-zim7nond 395 7 showed show VBD cord-282610-zim7nond 395 8 greatly greatly RB cord-282610-zim7nond 395 9 reduced reduce VBN cord-282610-zim7nond 395 10 correlations correlation NNS cord-282610-zim7nond 395 11 for for IN cord-282610-zim7nond 395 12 many many JJ cord-282610-zim7nond 395 13 immune immune JJ cord-282610-zim7nond 395 14 cell cell NN cord-282610-zim7nond 395 15 frequencies frequency NNS cord-282610-zim7nond 395 16 , , , cord-282610-zim7nond 395 17 cell cell NN cord-282610-zim7nond 395 18 signaling signal VBG cord-282610-zim7nond 395 19 responses response NNS cord-282610-zim7nond 395 20 , , , cord-282610-zim7nond 395 21 and and CC cord-282610-zim7nond 395 22 cytokine cytokine NN cord-282610-zim7nond 395 23 concentrations concentration NNS cord-282610-zim7nond 395 24 . . . cord-282610-zim7nond 396 1 In in IN cord-282610-zim7nond 396 2 general general JJ cord-282610-zim7nond 396 3 , , , cord-282610-zim7nond 396 4 the the DT cord-282610-zim7nond 396 5 influence influence NN cord-282610-zim7nond 396 6 of of IN cord-282610-zim7nond 396 7 CMV CMV NNP cord-282610-zim7nond 396 8 was be VBD cord-282610-zim7nond 396 9 so so RB cord-282610-zim7nond 396 10 broad broad JJ cord-282610-zim7nond 396 11 that that IN cord-282610-zim7nond 396 12 it -PRON- PRP cord-282610-zim7nond 396 13 affected affect VBD cord-282610-zim7nond 396 14 119 119 CD cord-282610-zim7nond 396 15 of of IN cord-282610-zim7nond 396 16 the the DT cord-282610-zim7nond 396 17 204 204 CD cord-282610-zim7nond 396 18 measurements measurement NNS cord-282610-zim7nond 396 19 dispersed disperse VBN cord-282610-zim7nond 396 20 throughout throughout IN cord-282610-zim7nond 396 21 the the DT cord-282610-zim7nond 396 22 immune immune JJ cord-282610-zim7nond 396 23 network network NN cord-282610-zim7nond 396 24 . . . cord-282610-zim7nond 397 1 These these DT cord-282610-zim7nond 397 2 and and CC cord-282610-zim7nond 397 3 related related JJ cord-282610-zim7nond 397 4 findings finding NNS cord-282610-zim7nond 397 5 led lead VBD cord-282610-zim7nond 397 6 Brodin Brodin NNP cord-282610-zim7nond 397 7 and and CC cord-282610-zim7nond 397 8 team team NN cord-282610-zim7nond 397 9 to to TO cord-282610-zim7nond 397 10 conclude conclude VB cord-282610-zim7nond 397 11 that that IN cord-282610-zim7nond 397 12 the the DT cord-282610-zim7nond 397 13 immune immune JJ cord-282610-zim7nond 397 14 response response NN cord-282610-zim7nond 397 15 is be VBZ cord-282610-zim7nond 397 16 " " `` cord-282610-zim7nond 397 17 very very RB cord-282610-zim7nond 397 18 much much RB cord-282610-zim7nond 397 19 shaped shape VBN cord-282610-zim7nond 397 20 by by IN cord-282610-zim7nond 397 21 the the DT cord-282610-zim7nond 397 22 environment environment NN cord-282610-zim7nond 397 23 and and CC cord-282610-zim7nond 397 24 most most RBS cord-282610-zim7nond 397 25 likely likely JJ cord-282610-zim7nond 397 26 by by IN cord-282610-zim7nond 397 27 the the DT cord-282610-zim7nond 397 28 many many JJ cord-282610-zim7nond 397 29 different different JJ cord-282610-zim7nond 397 30 microbes microbe NNS cord-282610-zim7nond 397 31 an an DT cord-282610-zim7nond 397 32 individual individual JJ cord-282610-zim7nond 397 33 encounters encounter NNS cord-282610-zim7nond 397 34 in in IN cord-282610-zim7nond 397 35 their -PRON- PRP$ cord-282610-zim7nond 397 36 lifetime lifetime NN cord-282610-zim7nond 397 37 . . . cord-282610-zim7nond 398 1 " " '' cord-282610-zim7nond 399 1 The the DT cord-282610-zim7nond 399 2 above above RB cord-282610-zim7nond 399 3 suggests suggest VBZ cord-282610-zim7nond 399 4 that that IN cord-282610-zim7nond 399 5 ME ME NNP cord-282610-zim7nond 399 6 / / SYM cord-282610-zim7nond 399 7 CFS CFS NNP cord-282610-zim7nond 399 8 may may MD cord-282610-zim7nond 399 9 be be VB cord-282610-zim7nond 399 10 driven drive VBN cord-282610-zim7nond 399 11 by by IN cord-282610-zim7nond 399 12 a a DT cord-282610-zim7nond 399 13 process process NN cord-282610-zim7nond 399 14 we -PRON- PRP cord-282610-zim7nond 399 15 have have VBP cord-282610-zim7nond 399 16 termed term VBN cord-282610-zim7nond 399 17 " " `` cord-282610-zim7nond 399 18 successive successive JJ cord-282610-zim7nond 399 19 infection infection NN cord-282610-zim7nond 399 20 . . . cord-282610-zim7nond 400 1 " " `` cord-282610-zim7nond 400 2 During during IN cord-282610-zim7nond 400 3 successive successive JJ cord-282610-zim7nond 400 4 infection infection NN cord-282610-zim7nond 400 5 , , , cord-282610-zim7nond 400 6 an an DT cord-282610-zim7nond 400 7 " " `` cord-282610-zim7nond 400 8 acute acute JJ cord-282610-zim7nond 400 9 " " '' cord-282610-zim7nond 400 10 infection infection NN cord-282610-zim7nond 400 11 or or CC cord-282610-zim7nond 400 12 " " `` cord-282610-zim7nond 400 13 initial initial JJ cord-282610-zim7nond 400 14 immunosuppressive immunosuppressive JJ cord-282610-zim7nond 400 15 event event NN cord-282610-zim7nond 400 16 " " '' cord-282610-zim7nond 400 17 dysregulates dysregulate VBZ cord-282610-zim7nond 400 18 the the DT cord-282610-zim7nond 400 19 host host NN cord-282610-zim7nond 400 20 immune immune JJ cord-282610-zim7nond 400 21 system system NN cord-282610-zim7nond 400 22 . . . cord-282610-zim7nond 401 1 This this DT cord-282610-zim7nond 401 2 makes make VBZ cord-282610-zim7nond 401 3 it -PRON- PRP cord-282610-zim7nond 401 4 easier easy JJR cord-282610-zim7nond 401 5 for for IN cord-282610-zim7nond 401 6 microbes microbe NNS cord-282610-zim7nond 401 7 to to TO cord-282610-zim7nond 401 8 subvert subvert VB cord-282610-zim7nond 401 9 the the DT cord-282610-zim7nond 401 10 immune immune JJ cord-282610-zim7nond 401 11 response response NN cord-282610-zim7nond 401 12 by by IN cord-282610-zim7nond 401 13 acting act VBG cord-282610-zim7nond 401 14 as as IN cord-282610-zim7nond 401 15 polymicrobial polymicrobial JJ cord-282610-zim7nond 401 16 entities entity NNS cord-282610-zim7nond 401 17 . . . cord-282610-zim7nond 402 1 Pathobionts pathobiont NNS cord-282610-zim7nond 402 2 alter alter VBP cord-282610-zim7nond 402 3 their -PRON- PRP$ cord-282610-zim7nond 402 4 gene gene NN cord-282610-zim7nond 402 5 expression expression NN cord-282610-zim7nond 402 6 to to TO cord-282610-zim7nond 402 7 better better RB cord-282610-zim7nond 402 8 promote promote VB cord-282610-zim7nond 402 9 community community NN cord-282610-zim7nond 402 10 - - HYPH cord-282610-zim7nond 402 11 wide wide JJ cord-282610-zim7nond 402 12 virulence virulence NN cord-282610-zim7nond 402 13 . . . cord-282610-zim7nond 403 1 Infected infected JJ cord-282610-zim7nond 403 2 human human JJ cord-282610-zim7nond 403 3 cells cell NNS cord-282610-zim7nond 403 4 fail fail VBP cord-282610-zim7nond 403 5 to to TO cord-282610-zim7nond 403 6 correctly correctly RB cord-282610-zim7nond 403 7 express express VB cord-282610-zim7nond 403 8 human human JJ cord-282610-zim7nond 403 9 metabolites metabolite NNS cord-282610-zim7nond 403 10 in in IN cord-282610-zim7nond 403 11 the the DT cord-282610-zim7nond 403 12 presence presence NN cord-282610-zim7nond 403 13 of of IN cord-282610-zim7nond 403 14 pathogen pathogen NN cord-282610-zim7nond 403 15 - - HYPH cord-282610-zim7nond 403 16 generated generate VBN cord-282610-zim7nond 403 17 proteins protein NNS cord-282610-zim7nond 403 18 , , , cord-282610-zim7nond 403 19 metabolites metabolite NNS cord-282610-zim7nond 403 20 , , , cord-282610-zim7nond 403 21 and and CC cord-282610-zim7nond 403 22 enzymes enzyme NNS cord-282610-zim7nond 403 23 . . . cord-282610-zim7nond 404 1 Dysfunction dysfunction NN cord-282610-zim7nond 404 2 driven drive VBN cord-282610-zim7nond 404 3 by by IN cord-282610-zim7nond 404 4 molecular molecular JJ cord-282610-zim7nond 404 5 mimicry mimicry NN cord-282610-zim7nond 404 6 increases increase NNS cord-282610-zim7nond 404 7 . . . cord-282610-zim7nond 405 1 Certain certain JJ cord-282610-zim7nond 405 2 pathogens pathogen NNS cord-282610-zim7nond 405 3 may may MD cord-282610-zim7nond 405 4 infect infect VB cord-282610-zim7nond 405 5 mitochondria mitochondrion NNS cord-282610-zim7nond 405 6 or or CC cord-282610-zim7nond 405 7 central central JJ cord-282610-zim7nond 405 8 nervous nervous JJ cord-282610-zim7nond 405 9 system system NN cord-282610-zim7nond 405 10 tissue tissue NN cord-282610-zim7nond 405 11 . . . cord-282610-zim7nond 406 1 Intracellular Intracellular NNP cord-282610-zim7nond 406 2 pathogens pathogen NNS cord-282610-zim7nond 406 3 slow slow VBP cord-282610-zim7nond 406 4 the the DT cord-282610-zim7nond 406 5 human human JJ cord-282610-zim7nond 406 6 immune immune JJ cord-282610-zim7nond 406 7 response response NN cord-282610-zim7nond 406 8 , , , cord-282610-zim7nond 406 9 causing cause VBG cord-282610-zim7nond 406 10 the the DT cord-282610-zim7nond 406 11 host host NN cord-282610-zim7nond 406 12 to to IN cord-282610-zim7nond 406 13 more more RBR cord-282610-zim7nond 406 14 easily easily RB cord-282610-zim7nond 406 15 acquire acquire VB cord-282610-zim7nond 406 16 other other JJ cord-282610-zim7nond 406 17 infectious infectious JJ cord-282610-zim7nond 406 18 agents agent NNS cord-282610-zim7nond 406 19 . . . cord-282610-zim7nond 407 1 This this DT cord-282610-zim7nond 407 2 creates create VBZ cord-282610-zim7nond 407 3 a a DT cord-282610-zim7nond 407 4 snowball snowball NN cord-282610-zim7nond 407 5 effect effect NN cord-282610-zim7nond 407 6 in in IN cord-282610-zim7nond 407 7 which which WDT cord-282610-zim7nond 407 8 the the DT cord-282610-zim7nond 407 9 microbiome microbiome NN cord-282610-zim7nond 407 10 becomes become VBZ cord-282610-zim7nond 407 11 increasingly increasingly RB cord-282610-zim7nond 407 12 dysbiotic dysbiotic JJ cord-282610-zim7nond 407 13 as as IN cord-282610-zim7nond 407 14 the the DT cord-282610-zim7nond 407 15 strength strength NN cord-282610-zim7nond 407 16 of of IN cord-282610-zim7nond 407 17 the the DT cord-282610-zim7nond 407 18 immune immune JJ cord-282610-zim7nond 407 19 response response NN cord-282610-zim7nond 407 20 weakens weaken VBZ cord-282610-zim7nond 407 21 over over IN cord-282610-zim7nond 407 22 time time NN cord-282610-zim7nond 407 23 . . . cord-282610-zim7nond 408 1 Eventually eventually RB cord-282610-zim7nond 408 2 , , , cord-282610-zim7nond 408 3 the the DT cord-282610-zim7nond 408 4 human human JJ cord-282610-zim7nond 408 5 host host NN cord-282610-zim7nond 408 6 may may MD cord-282610-zim7nond 408 7 present present VB cord-282610-zim7nond 408 8 with with IN cord-282610-zim7nond 408 9 symptoms symptom NNS cord-282610-zim7nond 408 10 characteristic characteristic JJ cord-282610-zim7nond 408 11 of of IN cord-282610-zim7nond 408 12 ME ME NNP cord-282610-zim7nond 408 13 / / SYM cord-282610-zim7nond 408 14 CFS CFS NNP cord-282610-zim7nond 408 15 or or CC cord-282610-zim7nond 408 16 a a DT cord-282610-zim7nond 408 17 related related JJ cord-282610-zim7nond 408 18 inflammatory inflammatory JJ cord-282610-zim7nond 408 19 diagnosis diagnosis NN cord-282610-zim7nond 408 20 . . . cord-282610-zim7nond 409 1 The the DT cord-282610-zim7nond 409 2 unique unique JJ cord-282610-zim7nond 409 3 symptoms symptom NNS cord-282610-zim7nond 409 4 any any DT cord-282610-zim7nond 409 5 one one CD cord-282610-zim7nond 409 6 patient patient NN cord-282610-zim7nond 409 7 develops develop VBZ cord-282610-zim7nond 409 8 are be VBP cord-282610-zim7nond 409 9 expected expect VBN cord-282610-zim7nond 409 10 to to TO cord-282610-zim7nond 409 11 vary vary VB cord-282610-zim7nond 409 12 based base VBN cord-282610-zim7nond 409 13 on on IN cord-282610-zim7nond 409 14 the the DT cord-282610-zim7nond 409 15 species specie NNS cord-282610-zim7nond 409 16 , , , cord-282610-zim7nond 409 17 strain strain NN cord-282610-zim7nond 409 18 , , , cord-282610-zim7nond 409 19 virulence virulence NN cord-282610-zim7nond 409 20 , , , cord-282610-zim7nond 409 21 and and CC cord-282610-zim7nond 409 22 location location NN cord-282610-zim7nond 409 23 of of IN cord-282610-zim7nond 409 24 the the DT cord-282610-zim7nond 409 25 pathogens pathogen NNS cord-282610-zim7nond 409 26 driving drive VBG cord-282610-zim7nond 409 27 dysbiosis dysbiosis NN cord-282610-zim7nond 409 28 , , , cord-282610-zim7nond 409 29 along along IN cord-282610-zim7nond 409 30 with with IN cord-282610-zim7nond 409 31 the the DT cord-282610-zim7nond 409 32 myriad myriad JJ cord-282610-zim7nond 409 33 ways way NNS cord-282610-zim7nond 409 34 in in IN cord-282610-zim7nond 409 35 which which WDT cord-282610-zim7nond 409 36 the the DT cord-282610-zim7nond 409 37 metabolites metabolite NNS cord-282610-zim7nond 409 38 and and CC cord-282610-zim7nond 409 39 proteins protein NNS cord-282610-zim7nond 409 40 created create VBN cord-282610-zim7nond 409 41 by by IN cord-282610-zim7nond 409 42 these these DT cord-282610-zim7nond 409 43 organisms organism NNS cord-282610-zim7nond 409 44 cause cause VBP cord-282610-zim7nond 409 45 dysfunction dysfunction NN cord-282610-zim7nond 409 46 by by IN cord-282610-zim7nond 409 47 interacting interact VBG cord-282610-zim7nond 409 48 with with IN cord-282610-zim7nond 409 49 those those DT cord-282610-zim7nond 409 50 of of IN cord-282610-zim7nond 409 51 the the DT cord-282610-zim7nond 409 52 host host NN cord-282610-zim7nond 409 53 . . . cord-282610-zim7nond 410 1 Early early JJ cord-282610-zim7nond 410 2 childhood childhood NN cord-282610-zim7nond 410 3 infections infection NNS cord-282610-zim7nond 410 4 may may MD cord-282610-zim7nond 410 5 predispose predispose VB cord-282610-zim7nond 410 6 to to TO cord-282610-zim7nond 410 7 dysbiosis dysbiosis VB cord-282610-zim7nond 410 8 at at IN cord-282610-zim7nond 410 9 a a DT cord-282610-zim7nond 410 10 later later JJ cord-282610-zim7nond 410 11 date date NN cord-282610-zim7nond 410 12 ( ( -LRB- cord-282610-zim7nond 410 13 157 157 CD cord-282610-zim7nond 410 14 ) ) -RRB- cord-282610-zim7nond 410 15 . . . cord-282610-zim7nond 411 1 For for IN cord-282610-zim7nond 411 2 example example NN cord-282610-zim7nond 411 3 , , , cord-282610-zim7nond 411 4 measles measles NN cord-282610-zim7nond 411 5 depletes deplete VBZ cord-282610-zim7nond 411 6 host host NN cord-282610-zim7nond 411 7 B b NN cord-282610-zim7nond 411 8 and and CC cord-282610-zim7nond 411 9 T t NN cord-282610-zim7nond 411 10 lymphocytes lymphocyte NNS cord-282610-zim7nond 411 11 for for IN cord-282610-zim7nond 411 12 up up IN cord-282610-zim7nond 411 13 to to TO cord-282610-zim7nond 411 14 2 2 CD cord-282610-zim7nond 411 15 - - SYM cord-282610-zim7nond 411 16 3 3 CD cord-282610-zim7nond 411 17 years year NNS cord-282610-zim7nond 411 18 after after IN cord-282610-zim7nond 411 19 initial initial JJ cord-282610-zim7nond 411 20 infection infection NN cord-282610-zim7nond 411 21 . . . cord-282610-zim7nond 412 1 This this DT cord-282610-zim7nond 412 2 immunosuppression immunosuppression NN cord-282610-zim7nond 412 3 can can MD cord-282610-zim7nond 412 4 reset reset VB cord-282610-zim7nond 412 5 previously previously RB cord-282610-zim7nond 412 6 acquired acquire VBN cord-282610-zim7nond 412 7 immunity immunity NN cord-282610-zim7nond 412 8 and and CC cord-282610-zim7nond 412 9 renders render VBZ cord-282610-zim7nond 412 10 the the DT cord-282610-zim7nond 412 11 host host NN cord-282610-zim7nond 412 12 more more RBR cord-282610-zim7nond 412 13 susceptible susceptible JJ cord-282610-zim7nond 412 14 to to IN cord-282610-zim7nond 412 15 other other JJ cord-282610-zim7nond 412 16 pathogens pathogen NNS cord-282610-zim7nond 412 17 ( ( -LRB- cord-282610-zim7nond 412 18 158 158 CD cord-282610-zim7nond 412 19 ) ) -RRB- cord-282610-zim7nond 412 20 . . . cord-282610-zim7nond 413 1 In in IN cord-282610-zim7nond 413 2 other other JJ cord-282610-zim7nond 413 3 cases case NNS cord-282610-zim7nond 413 4 , , , cord-282610-zim7nond 413 5 a a DT cord-282610-zim7nond 413 6 toxic toxic JJ cord-282610-zim7nond 413 7 environmental environmental JJ cord-282610-zim7nond 413 8 exposure exposure NN cord-282610-zim7nond 413 9 , , , cord-282610-zim7nond 413 10 infection infection NN cord-282610-zim7nond 413 11 during during IN cord-282610-zim7nond 413 12 surgery surgery NN cord-282610-zim7nond 413 13 or or CC cord-282610-zim7nond 413 14 the the DT cord-282610-zim7nond 413 15 difficulty difficulty NN cord-282610-zim7nond 413 16 of of IN cord-282610-zim7nond 413 17 enduring endure VBG cord-282610-zim7nond 413 18 a a DT cord-282610-zim7nond 413 19 traumatic traumatic JJ cord-282610-zim7nond 413 20 event event NN cord-282610-zim7nond 413 21 may may MD cord-282610-zim7nond 413 22 weaken weaken VB cord-282610-zim7nond 413 23 the the DT cord-282610-zim7nond 413 24 immune immune JJ cord-282610-zim7nond 413 25 response response NN cord-282610-zim7nond 413 26 to to IN cord-282610-zim7nond 413 27 a a DT cord-282610-zim7nond 413 28 point point NN cord-282610-zim7nond 413 29 where where WRB cord-282610-zim7nond 413 30 previously previously RB cord-282610-zim7nond 413 31 subclinical subclinical JJ cord-282610-zim7nond 413 32 infections infection NNS cord-282610-zim7nond 413 33 become become VBP cord-282610-zim7nond 413 34 active active JJ cord-282610-zim7nond 413 35 . . . cord-282610-zim7nond 414 1 ME ME NNP cord-282610-zim7nond 414 2 / / SYM cord-282610-zim7nond 414 3 CFS CFS NNP cord-282610-zim7nond 414 4 outbreaks outbreak NNS cord-282610-zim7nond 414 5 , , , cord-282610-zim7nond 414 6 in in IN cord-282610-zim7nond 414 7 which which WDT cord-282610-zim7nond 414 8 numerous numerous JJ cord-282610-zim7nond 414 9 patients patient NNS cord-282610-zim7nond 414 10 developed develop VBD cord-282610-zim7nond 414 11 the the DT cord-282610-zim7nond 414 12 illness illness NN cord-282610-zim7nond 414 13 at at IN cord-282610-zim7nond 414 14 relatively relatively RB cord-282610-zim7nond 414 15 the the DT cord-282610-zim7nond 414 16 same same JJ cord-282610-zim7nond 414 17 time time NN cord-282610-zim7nond 414 18 , , , cord-282610-zim7nond 414 19 may may MD cord-282610-zim7nond 414 20 well well RB cord-282610-zim7nond 414 21 represent represent VB cord-282610-zim7nond 414 22 this this DT cord-282610-zim7nond 414 23 phenomenon phenomenon NN cord-282610-zim7nond 414 24 at at IN cord-282610-zim7nond 414 25 work work NN cord-282610-zim7nond 414 26 . . . cord-282610-zim7nond 415 1 The the DT cord-282610-zim7nond 415 2 successive successive JJ cord-282610-zim7nond 415 3 infectious infectious JJ cord-282610-zim7nond 415 4 process process NN cord-282610-zim7nond 415 5 may may MD cord-282610-zim7nond 415 6 even even RB cord-282610-zim7nond 415 7 begin begin VB cord-282610-zim7nond 415 8 in in IN cord-282610-zim7nond 415 9 the the DT cord-282610-zim7nond 415 10 womb womb NN cord-282610-zim7nond 415 11 . . . cord-282610-zim7nond 416 1 Depending depend VBG cord-282610-zim7nond 416 2 on on IN cord-282610-zim7nond 416 3 the the DT cord-282610-zim7nond 416 4 health health NN cord-282610-zim7nond 416 5 of of IN cord-282610-zim7nond 416 6 the the DT cord-282610-zim7nond 416 7 parent parent NN cord-282610-zim7nond 416 8 , , , cord-282610-zim7nond 416 9 founding found VBG cord-282610-zim7nond 416 10 microbiome microbiome NN cord-282610-zim7nond 416 11 communities community NNS cord-282610-zim7nond 416 12 in in IN cord-282610-zim7nond 416 13 the the DT cord-282610-zim7nond 416 14 placenta placenta NN cord-282610-zim7nond 416 15 , , , cord-282610-zim7nond 416 16 vagina vagina NN cord-282610-zim7nond 416 17 and and CC cord-282610-zim7nond 416 18 breast breast NN cord-282610-zim7nond 416 19 milk milk NN cord-282610-zim7nond 416 20 may may MD cord-282610-zim7nond 416 21 already already RB cord-282610-zim7nond 416 22 be be VB cord-282610-zim7nond 416 23 dysbiotic dysbiotic JJ cord-282610-zim7nond 416 24 . . . cord-282610-zim7nond 417 1 Cabrera Cabrera NNP cord-282610-zim7nond 417 2 - - HYPH cord-282610-zim7nond 417 3 Rubio Rubio NNP cord-282610-zim7nond 417 4 et et NNP cord-282610-zim7nond 417 5 al al NNP cord-282610-zim7nond 417 6 . . . cord-282610-zim7nond 418 1 ( ( -LRB- cord-282610-zim7nond 418 2 159 159 CD cord-282610-zim7nond 418 3 ) ) -RRB- cord-282610-zim7nond 418 4 found find VBD cord-282610-zim7nond 418 5 that that IN cord-282610-zim7nond 418 6 the the DT cord-282610-zim7nond 418 7 breast breast NN cord-282610-zim7nond 418 8 milk milk NN cord-282610-zim7nond 418 9 microbiome microbiome NN cord-282610-zim7nond 418 10 of of IN cord-282610-zim7nond 418 11 obese obese JJ cord-282610-zim7nond 418 12 mothers mother NNS cord-282610-zim7nond 418 13 tended tend VBD cord-282610-zim7nond 418 14 to to TO cord-282610-zim7nond 418 15 contain contain VB cord-282610-zim7nond 418 16 a a DT cord-282610-zim7nond 418 17 different different JJ cord-282610-zim7nond 418 18 and and CC cord-282610-zim7nond 418 19 less less RBR cord-282610-zim7nond 418 20 diverse diverse JJ cord-282610-zim7nond 418 21 bacterial bacterial JJ cord-282610-zim7nond 418 22 community community NN cord-282610-zim7nond 418 23 then then RB cord-282610-zim7nond 418 24 that that DT cord-282610-zim7nond 418 25 of of IN cord-282610-zim7nond 418 26 normal normal JJ cord-282610-zim7nond 418 27 - - HYPH cord-282610-zim7nond 418 28 weight weight NN cord-282610-zim7nond 418 29 mothers mother NNS cord-282610-zim7nond 418 30 . . . cord-282610-zim7nond 419 1 Pathogens pathogen NNS cord-282610-zim7nond 419 2 in in IN cord-282610-zim7nond 419 3 the the DT cord-282610-zim7nond 419 4 placental placental NN cord-282610-zim7nond 419 5 microbiome microbiome NN cord-282610-zim7nond 419 6 can can MD cord-282610-zim7nond 419 7 alter alter VB cord-282610-zim7nond 419 8 methylation methylation NN cord-282610-zim7nond 419 9 of of IN cord-282610-zim7nond 419 10 human human JJ cord-282610-zim7nond 419 11 DNA dna NN cord-282610-zim7nond 419 12 in in IN cord-282610-zim7nond 419 13 a a DT cord-282610-zim7nond 419 14 manner manner NN cord-282610-zim7nond 419 15 that that WDT cord-282610-zim7nond 419 16 may may MD cord-282610-zim7nond 419 17 negatively negatively RB cord-282610-zim7nond 419 18 impact impact VB cord-282610-zim7nond 419 19 the the DT cord-282610-zim7nond 419 20 later later JJ cord-282610-zim7nond 419 21 life life NN cord-282610-zim7nond 419 22 disease disease NN cord-282610-zim7nond 419 23 of of IN cord-282610-zim7nond 419 24 premature premature JJ cord-282610-zim7nond 419 25 babies baby NNS cord-282610-zim7nond 419 26 ( ( -LRB- cord-282610-zim7nond 419 27 160 160 CD cord-282610-zim7nond 419 28 ) ) -RRB- cord-282610-zim7nond 419 29 . . . cord-282610-zim7nond 420 1 Many many JJ cord-282610-zim7nond 420 2 aspects aspect NNS cord-282610-zim7nond 420 3 of of IN cord-282610-zim7nond 420 4 modern modern JJ cord-282610-zim7nond 420 5 living living NN cord-282610-zim7nond 420 6 can can MD cord-282610-zim7nond 420 7 additionally additionally RB cord-282610-zim7nond 420 8 drive drive VB cord-282610-zim7nond 420 9 successive successive JJ cord-282610-zim7nond 420 10 infection infection NN cord-282610-zim7nond 420 11 . . . cord-282610-zim7nond 421 1 Antibiotic antibiotic JJ cord-282610-zim7nond 421 2 use use NN cord-282610-zim7nond 421 3 disrupts disrupt VBZ cord-282610-zim7nond 421 4 the the DT cord-282610-zim7nond 421 5 ecology ecology NN cord-282610-zim7nond 421 6 of of IN cord-282610-zim7nond 421 7 the the DT cord-282610-zim7nond 421 8 human human JJ cord-282610-zim7nond 421 9 microbiome microbiome NN cord-282610-zim7nond 421 10 ( ( -LRB- cord-282610-zim7nond 421 11 161 161 CD cord-282610-zim7nond 421 12 ) ) -RRB- cord-282610-zim7nond 421 13 . . . cord-282610-zim7nond 422 1 Antibiotic antibiotic JJ cord-282610-zim7nond 422 2 resistance resistance NN cord-282610-zim7nond 422 3 genes gene NNS cord-282610-zim7nond 422 4 from from IN cord-282610-zim7nond 422 5 farm farm NN cord-282610-zim7nond 422 6 animals animal NNS cord-282610-zim7nond 422 7 and and CC cord-282610-zim7nond 422 8 produce produce VBP cord-282610-zim7nond 422 9 are be VBP cord-282610-zim7nond 422 10 regularly regularly RB cord-282610-zim7nond 422 11 transferred transfer VBN cord-282610-zim7nond 422 12 into into IN cord-282610-zim7nond 422 13 the the DT cord-282610-zim7nond 422 14 human human JJ cord-282610-zim7nond 422 15 food food NN cord-282610-zim7nond 422 16 supply supply NN cord-282610-zim7nond 422 17 ( ( -LRB- cord-282610-zim7nond 422 18 162 162 CD cord-282610-zim7nond 422 19 ) ) -RRB- cord-282610-zim7nond 422 20 . . . cord-282610-zim7nond 423 1 Electromagnetic electromagnetic JJ cord-282610-zim7nond 423 2 radiation radiation NN cord-282610-zim7nond 423 3 has have VBZ cord-282610-zim7nond 423 4 been be VBN cord-282610-zim7nond 423 5 shown show VBN cord-282610-zim7nond 423 6 to to TO cord-282610-zim7nond 423 7 lower low JJR cord-282610-zim7nond 423 8 immunity immunity NN cord-282610-zim7nond 423 9 ( ( -LRB- cord-282610-zim7nond 423 10 163 163 CD cord-282610-zim7nond 423 11 ) ) -RRB- cord-282610-zim7nond 423 12 . . . cord-282610-zim7nond 424 1 The the DT cord-282610-zim7nond 424 2 immunosuppressive immunosuppressive JJ cord-282610-zim7nond 424 3 biologics biologic NNS cord-282610-zim7nond 424 4 and and CC cord-282610-zim7nond 424 5 supplements supplement NNS cord-282610-zim7nond 424 6 often often RB cord-282610-zim7nond 424 7 prescribed prescribe VBD cord-282610-zim7nond 424 8 for for IN cord-282610-zim7nond 424 9 inflammatory inflammatory JJ cord-282610-zim7nond 424 10 disease disease NN cord-282610-zim7nond 424 11 further further RB cord-282610-zim7nond 424 12 allow allow VB cord-282610-zim7nond 424 13 pathobionts pathobiont NNS cord-282610-zim7nond 424 14 in in IN cord-282610-zim7nond 424 15 the the DT cord-282610-zim7nond 424 16 microbiome microbiome NN cord-282610-zim7nond 424 17 to to TO cord-282610-zim7nond 424 18 proliferate proliferate VB cord-282610-zim7nond 424 19 . . . cord-282610-zim7nond 425 1 For for IN cord-282610-zim7nond 425 2 example example NN cord-282610-zim7nond 425 3 , , , cord-282610-zim7nond 425 4 Diaz Diaz NNP cord-282610-zim7nond 425 5 et et NNP cord-282610-zim7nond 425 6 al al NNP cord-282610-zim7nond 425 7 . . . cord-282610-zim7nond 426 1 ( ( -LRB- cord-282610-zim7nond 426 2 164 164 CD cord-282610-zim7nond 426 3 ) ) -RRB- cord-282610-zim7nond 426 4 found find VBD cord-282610-zim7nond 426 5 that that IN cord-282610-zim7nond 426 6 the the DT cord-282610-zim7nond 426 7 salivary salivary NN cord-282610-zim7nond 426 8 bacteriome bacteriome NN cord-282610-zim7nond 426 9 of of IN cord-282610-zim7nond 426 10 patients patient NNS cord-282610-zim7nond 426 11 taking take VBG cord-282610-zim7nond 426 12 immunosuppressive immunosuppressive JJ cord-282610-zim7nond 426 13 biologics biologic NNS cord-282610-zim7nond 426 14 was be VBD cord-282610-zim7nond 426 15 more more RBR cord-282610-zim7nond 426 16 permissive permissive JJ cord-282610-zim7nond 426 17 to to IN cord-282610-zim7nond 426 18 the the DT cord-282610-zim7nond 426 19 growth growth NN cord-282610-zim7nond 426 20 of of IN cord-282610-zim7nond 426 21 oral oral JJ cord-282610-zim7nond 426 22 opportunistic opportunistic JJ cord-282610-zim7nond 426 23 pathogens pathogen NNS cord-282610-zim7nond 426 24 . . . cord-282610-zim7nond 427 1 Modern modern JJ cord-282610-zim7nond 427 2 society society NN cord-282610-zim7nond 427 3 also also RB cord-282610-zim7nond 427 4 exposes expose VBZ cord-282610-zim7nond 427 5 the the DT cord-282610-zim7nond 427 6 average average JJ cord-282610-zim7nond 427 7 person person NN cord-282610-zim7nond 427 8 to to IN cord-282610-zim7nond 427 9 pathogens pathogen NNS cord-282610-zim7nond 427 10 our -PRON- PRP$ cord-282610-zim7nond 427 11 recent recent JJ cord-282610-zim7nond 427 12 ancestors ancestor NNS cord-282610-zim7nond 427 13 were be VBD cord-282610-zim7nond 427 14 unlikely unlikely JJ cord-282610-zim7nond 427 15 to to TO cord-282610-zim7nond 427 16 encounter encounter VB cord-282610-zim7nond 427 17 . . . cord-282610-zim7nond 428 1 International international JJ cord-282610-zim7nond 428 2 airports airport NNS cord-282610-zim7nond 428 3 harbor harbor VBP cord-282610-zim7nond 428 4 pathogens pathogen NNS cord-282610-zim7nond 428 5 from from IN cord-282610-zim7nond 428 6 across across IN cord-282610-zim7nond 428 7 the the DT cord-282610-zim7nond 428 8 globe globe NN cord-282610-zim7nond 428 9 ( ( -LRB- cord-282610-zim7nond 428 10 165 165 CD cord-282610-zim7nond 428 11 ) ) -RRB- cord-282610-zim7nond 428 12 . . . cord-282610-zim7nond 429 1 Food food NN cord-282610-zim7nond 429 2 products product NNS cord-282610-zim7nond 429 3 , , , cord-282610-zim7nond 429 4 and and CC cord-282610-zim7nond 429 5 the the DT cord-282610-zim7nond 429 6 microbes microbe NNS cord-282610-zim7nond 429 7 they -PRON- PRP cord-282610-zim7nond 429 8 contain contain VBP cord-282610-zim7nond 429 9 , , , cord-282610-zim7nond 429 10 are be VBP cord-282610-zim7nond 429 11 frequently frequently RB cord-282610-zim7nond 429 12 imported import VBN cord-282610-zim7nond 429 13 from from IN cord-282610-zim7nond 429 14 foreign foreign JJ cord-282610-zim7nond 429 15 destinations destination NNS cord-282610-zim7nond 429 16 ( ( -LRB- cord-282610-zim7nond 429 17 166 166 CD cord-282610-zim7nond 429 18 ) ) -RRB- cord-282610-zim7nond 429 19 . . . cord-282610-zim7nond 430 1 One one CD cord-282610-zim7nond 430 2 study study NN cord-282610-zim7nond 430 3 found find VBD cord-282610-zim7nond 430 4 a a DT cord-282610-zim7nond 430 5 range range NN cord-282610-zim7nond 430 6 of of IN cord-282610-zim7nond 430 7 opportunistic opportunistic JJ cord-282610-zim7nond 430 8 pathogens pathogen NNS cord-282610-zim7nond 430 9 enriched enrich VBN cord-282610-zim7nond 430 10 in in IN cord-282610-zim7nond 430 11 showerhead showerhead NN cord-282610-zim7nond 430 12 biofilms biofilm NNS cord-282610-zim7nond 430 13 ( ( -LRB- cord-282610-zim7nond 430 14 167 167 CD cord-282610-zim7nond 430 15 ) ) -RRB- cord-282610-zim7nond 430 16 . . . cord-282610-zim7nond 431 1 Numerous numerous JJ cord-282610-zim7nond 431 2 pathogens pathogen NNS cord-282610-zim7nond 431 3 were be VBD cord-282610-zim7nond 431 4 identified identify VBN cord-282610-zim7nond 431 5 in in IN cord-282610-zim7nond 431 6 commonly commonly RB cord-282610-zim7nond 431 7 smoked smoke VBN cord-282610-zim7nond 431 8 cigarettes cigarette NNS cord-282610-zim7nond 431 9 ( ( -LRB- cord-282610-zim7nond 431 10 168 168 CD cord-282610-zim7nond 431 11 ) ) -RRB- cord-282610-zim7nond 431 12 . . . cord-282610-zim7nond 432 1 Many many JJ cord-282610-zim7nond 432 2 such such JJ cord-282610-zim7nond 432 3 pathogens pathogen NNS cord-282610-zim7nond 432 4 are be VBP cord-282610-zim7nond 432 5 capable capable JJ cord-282610-zim7nond 432 6 of of IN cord-282610-zim7nond 432 7 persisting persist VBG cord-282610-zim7nond 432 8 in in IN cord-282610-zim7nond 432 9 human human JJ cord-282610-zim7nond 432 10 microbiome microbiome NN cord-282610-zim7nond 432 11 ecosystems ecosystem NNS cord-282610-zim7nond 432 12 , , , cord-282610-zim7nond 432 13 where where WRB cord-282610-zim7nond 432 14 the the DT cord-282610-zim7nond 432 15 host host NN cord-282610-zim7nond 432 16 may may MD cord-282610-zim7nond 432 17 lack lack VB cord-282610-zim7nond 432 18 immunity immunity NN cord-282610-zim7nond 432 19 toward toward IN cord-282610-zim7nond 432 20 their -PRON- PRP$ cord-282610-zim7nond 432 21 presence presence NN cord-282610-zim7nond 432 22 . . . cord-282610-zim7nond 433 1 ME ME NNP cord-282610-zim7nond 433 2 / / SYM cord-282610-zim7nond 433 3 CFS CFS NNP cord-282610-zim7nond 433 4 is be VBZ cord-282610-zim7nond 433 5 a a DT cord-282610-zim7nond 433 6 spectrum spectrum JJ cord-282610-zim7nond 433 7 disorder disorder NN cord-282610-zim7nond 433 8 with with IN cord-282610-zim7nond 433 9 a a DT cord-282610-zim7nond 433 10 diagnostic diagnostic JJ cord-282610-zim7nond 433 11 criterion criterion NN cord-282610-zim7nond 433 12 that that WDT cord-282610-zim7nond 433 13 includes include VBZ cord-282610-zim7nond 433 14 a a DT cord-282610-zim7nond 433 15 range range NN cord-282610-zim7nond 433 16 of of IN cord-282610-zim7nond 433 17 physical physical JJ cord-282610-zim7nond 433 18 and and CC cord-282610-zim7nond 433 19 neurological neurological JJ cord-282610-zim7nond 433 20 symptoms symptom NNS cord-282610-zim7nond 433 21 ( ( -LRB- cord-282610-zim7nond 433 22 2 2 CD cord-282610-zim7nond 433 23 ) ) -RRB- cord-282610-zim7nond 433 24 . . . cord-282610-zim7nond 434 1 If if IN cord-282610-zim7nond 434 2 successive successive JJ cord-282610-zim7nond 434 3 infection infection NN cord-282610-zim7nond 434 4 contributes contribute VBZ cord-282610-zim7nond 434 5 to to IN cord-282610-zim7nond 434 6 ME ME NNP cord-282610-zim7nond 434 7 / / SYM cord-282610-zim7nond 434 8 CFS CFS NNP cord-282610-zim7nond 434 9 , , , cord-282610-zim7nond 434 10 this this DT cord-282610-zim7nond 434 11 variability variability NN cord-282610-zim7nond 434 12 in in IN cord-282610-zim7nond 434 13 symptom symptom NN cord-282610-zim7nond 434 14 presentation presentation NN cord-282610-zim7nond 434 15 is be VBZ cord-282610-zim7nond 434 16 expected expect VBN cord-282610-zim7nond 434 17 . . . cord-282610-zim7nond 435 1 Furthermore furthermore RB cord-282610-zim7nond 435 2 , , , cord-282610-zim7nond 435 3 factoring factor VBG cord-282610-zim7nond 435 4 " " `` cord-282610-zim7nond 435 5 unique unique JJ cord-282610-zim7nond 435 6 infectious infectious JJ cord-282610-zim7nond 435 7 history history NN cord-282610-zim7nond 435 8 " " '' cord-282610-zim7nond 435 9 into into IN cord-282610-zim7nond 435 10 the the DT cord-282610-zim7nond 435 11 disease disease NN cord-282610-zim7nond 435 12 process process NN cord-282610-zim7nond 435 13 helps help VBZ cord-282610-zim7nond 435 14 explain explain VB cord-282610-zim7nond 435 15 why why WRB cord-282610-zim7nond 435 16 patients patient NNS cord-282610-zim7nond 435 17 with with IN cord-282610-zim7nond 435 18 ME ME NNP cord-282610-zim7nond 435 19 / / SYM cord-282610-zim7nond 435 20 CFS CFS NNP cord-282610-zim7nond 435 21 often often RB cord-282610-zim7nond 435 22 suffer suffer VBP cord-282610-zim7nond 435 23 from from IN cord-282610-zim7nond 435 24 a a DT cord-282610-zim7nond 435 25 multitude multitude NN cord-282610-zim7nond 435 26 of of IN cord-282610-zim7nond 435 27 symptoms symptom NNS cord-282610-zim7nond 435 28 not not RB cord-282610-zim7nond 435 29 included include VBN cord-282610-zim7nond 435 30 in in IN cord-282610-zim7nond 435 31 the the DT cord-282610-zim7nond 435 32 official official JJ cord-282610-zim7nond 435 33 diagnostic diagnostic JJ cord-282610-zim7nond 435 34 criteria criterion NNS cord-282610-zim7nond 435 35 . . . cord-282610-zim7nond 436 1 Because because IN cord-282610-zim7nond 436 2 patients patient NNS cord-282610-zim7nond 436 3 with with IN cord-282610-zim7nond 436 4 ME ME NNP cord-282610-zim7nond 436 5 / / SYM cord-282610-zim7nond 436 6 CFS CFS NNP cord-282610-zim7nond 436 7 suffer suffer VBP cord-282610-zim7nond 436 8 from from IN cord-282610-zim7nond 436 9 such such JJ cord-282610-zim7nond 436 10 diverse diverse JJ cord-282610-zim7nond 436 11 symptoms symptom NNS cord-282610-zim7nond 436 12 , , , cord-282610-zim7nond 436 13 it -PRON- PRP cord-282610-zim7nond 436 14 has have VBZ cord-282610-zim7nond 436 15 been be VBN cord-282610-zim7nond 436 16 argued argue VBN cord-282610-zim7nond 436 17 that that IN cord-282610-zim7nond 436 18 they -PRON- PRP cord-282610-zim7nond 436 19 should should MD cord-282610-zim7nond 436 20 be be VB cord-282610-zim7nond 436 21 grouped group VBN cord-282610-zim7nond 436 22 into into IN cord-282610-zim7nond 436 23 separately separately RB cord-282610-zim7nond 436 24 studied study VBN cord-282610-zim7nond 436 25 " " `` cord-282610-zim7nond 436 26 subgroups subgroup NNS cord-282610-zim7nond 436 27 " " '' cord-282610-zim7nond 436 28 ( ( -LRB- cord-282610-zim7nond 436 29 169 169 CD cord-282610-zim7nond 436 30 ) ) -RRB- cord-282610-zim7nond 436 31 . . . cord-282610-zim7nond 437 1 In in IN cord-282610-zim7nond 437 2 some some DT cord-282610-zim7nond 437 3 cases case NNS cord-282610-zim7nond 437 4 this this DT cord-282610-zim7nond 437 5 makes make VBZ cord-282610-zim7nond 437 6 sense sense NN cord-282610-zim7nond 437 7 . . . cord-282610-zim7nond 438 1 For for IN cord-282610-zim7nond 438 2 example example NN cord-282610-zim7nond 438 3 , , , cord-282610-zim7nond 438 4 studies study NNS cord-282610-zim7nond 438 5 that that WDT cord-282610-zim7nond 438 6 distinguish distinguish VBP cord-282610-zim7nond 438 7 earlystage earlystage NN cord-282610-zim7nond 438 8 / / SYM cord-282610-zim7nond 438 9 late late JJ cord-282610-zim7nond 438 10 - - HYPH cord-282610-zim7nond 438 11 stage stage NN cord-282610-zim7nond 438 12 ME ME NNP cord-282610-zim7nond 438 13 / / SYM cord-282610-zim7nond 438 14 CFS CFS NNP cord-282610-zim7nond 438 15 patients patient NNS cord-282610-zim7nond 438 16 may may MD cord-282610-zim7nond 438 17 further further RB cord-282610-zim7nond 438 18 elucidate elucidate VB cord-282610-zim7nond 438 19 how how WRB cord-282610-zim7nond 438 20 the the DT cord-282610-zim7nond 438 21 immune immune JJ cord-282610-zim7nond 438 22 response response NN cord-282610-zim7nond 438 23 is be VBZ cord-282610-zim7nond 438 24 modified modify VBN cord-282610-zim7nond 438 25 by by IN cord-282610-zim7nond 438 26 the the DT cord-282610-zim7nond 438 27 microbiome microbiome NN cord-282610-zim7nond 438 28 over over IN cord-282610-zim7nond 438 29 time time NN cord-282610-zim7nond 438 30 . . . cord-282610-zim7nond 439 1 However however RB cord-282610-zim7nond 439 2 , , , cord-282610-zim7nond 439 3 if if IN cord-282610-zim7nond 439 4 successive successive JJ cord-282610-zim7nond 439 5 infection infection NN cord-282610-zim7nond 439 6 contributes contribute VBZ cord-282610-zim7nond 439 7 to to IN cord-282610-zim7nond 439 8 ME ME NNP cord-282610-zim7nond 439 9 / / SYM cord-282610-zim7nond 439 10 CFS CFS NNP cord-282610-zim7nond 439 11 , , , cord-282610-zim7nond 439 12 future future JJ cord-282610-zim7nond 439 13 research research NN cord-282610-zim7nond 439 14 should should MD cord-282610-zim7nond 439 15 also also RB cord-282610-zim7nond 439 16 focus focus VB cord-282610-zim7nond 439 17 on on IN cord-282610-zim7nond 439 18 better well JJR cord-282610-zim7nond 439 19 understanding understand VBG cord-282610-zim7nond 439 20 the the DT cord-282610-zim7nond 439 21 common common JJ cord-282610-zim7nond 439 22 pathogenesis pathogenesis NN cord-282610-zim7nond 439 23 shared share VBN cord-282610-zim7nond 439 24 by by IN cord-282610-zim7nond 439 25 all all DT cord-282610-zim7nond 439 26 subjects subject NNS cord-282610-zim7nond 439 27 . . . cord-282610-zim7nond 440 1 Indeed indeed RB cord-282610-zim7nond 440 2 , , , cord-282610-zim7nond 440 3 successive successive JJ cord-282610-zim7nond 440 4 infection infection NN cord-282610-zim7nond 440 5 may may MD cord-282610-zim7nond 440 6 contribute contribute VB cord-282610-zim7nond 440 7 to to IN cord-282610-zim7nond 440 8 other other JJ cord-282610-zim7nond 440 9 conditions condition NNS cord-282610-zim7nond 440 10 tied tie VBN cord-282610-zim7nond 440 11 to to IN cord-282610-zim7nond 440 12 microbiome microbiome NN cord-282610-zim7nond 440 13 dysbiosis dysbiosis NN cord-282610-zim7nond 440 14 , , , cord-282610-zim7nond 440 15 persistent persistent JJ cord-282610-zim7nond 440 16 infection infection NN cord-282610-zim7nond 440 17 , , , cord-282610-zim7nond 440 18 and and CC cord-282610-zim7nond 440 19 adverse adverse JJ cord-282610-zim7nond 440 20 environmental environmental JJ cord-282610-zim7nond 440 21 exposure exposure NN cord-282610-zim7nond 440 22 . . . cord-282610-zim7nond 441 1 ME ME NNP cord-282610-zim7nond 441 2 / / SYM cord-282610-zim7nond 441 3 CFS CFS NNP cord-282610-zim7nond 441 4 should should MD cord-282610-zim7nond 441 5 be be VB cord-282610-zim7nond 441 6 studied study VBN cord-282610-zim7nond 441 7 in in IN cord-282610-zim7nond 441 8 concert concert NN cord-282610-zim7nond 441 9 with with IN cord-282610-zim7nond 441 10 these these DT cord-282610-zim7nond 441 11 other other JJ cord-282610-zim7nond 441 12 conditions condition NNS cord-282610-zim7nond 441 13 , , , cord-282610-zim7nond 441 14 which which WDT cord-282610-zim7nond 441 15 include include VBP cord-282610-zim7nond 441 16 Gulf Gulf NNP cord-282610-zim7nond 441 17 War War NNP cord-282610-zim7nond 441 18 Syndrome Syndrome NNP cord-282610-zim7nond 441 19 , , , cord-282610-zim7nond 441 20 Ehlers Ehlers NNP cord-282610-zim7nond 441 21 - - HYPH cord-282610-zim7nond 441 22 Danlos Danlos NNP cord-282610-zim7nond 441 23 Syndrome Syndrome NNP cord-282610-zim7nond 441 24 , , , cord-282610-zim7nond 441 25 Chronic Chronic NNP cord-282610-zim7nond 441 26 Lyme Lyme NNP cord-282610-zim7nond 441 27 Disease Disease NNP cord-282610-zim7nond 441 28 , , , cord-282610-zim7nond 441 29 and and CC cord-282610-zim7nond 441 30 fibromyalgia fibromyalgia NN cord-282610-zim7nond 441 31 among among IN cord-282610-zim7nond 441 32 others other NNS cord-282610-zim7nond 441 33 ( ( -LRB- cord-282610-zim7nond 441 34 170 170 CD cord-282610-zim7nond 441 35 ) ) -RRB- cord-282610-zim7nond 441 36 ( ( -LRB- cord-282610-zim7nond 441 37 171 171 CD cord-282610-zim7nond 441 38 ) ) -RRB- cord-282610-zim7nond 441 39 ( ( -LRB- cord-282610-zim7nond 441 40 172 172 CD cord-282610-zim7nond 441 41 ) ) -RRB- cord-282610-zim7nond 441 42 ( ( -LRB- cord-282610-zim7nond 441 43 173 173 CD cord-282610-zim7nond 441 44 ) ) -RRB- cord-282610-zim7nond 441 45 ( ( -LRB- cord-282610-zim7nond 441 46 174 174 CD cord-282610-zim7nond 441 47 ) ) -RRB- cord-282610-zim7nond 441 48 . . . cord-282610-zim7nond 442 1 The the DT cord-282610-zim7nond 442 2 high high JJ cord-282610-zim7nond 442 3 levels level NNS cord-282610-zim7nond 442 4 of of IN cord-282610-zim7nond 442 5 comorbidity comorbidity NN cord-282610-zim7nond 442 6 and and CC cord-282610-zim7nond 442 7 symptom symptom NN cord-282610-zim7nond 442 8 overlap overlap NN cord-282610-zim7nond 442 9 between between IN cord-282610-zim7nond 442 10 patients patient NNS cord-282610-zim7nond 442 11 with with IN cord-282610-zim7nond 442 12 ME ME NNP cord-282610-zim7nond 442 13 / / SYM cord-282610-zim7nond 442 14 CFS CFS NNP cord-282610-zim7nond 442 15 and and CC cord-282610-zim7nond 442 16 these these DT cord-282610-zim7nond 442 17 related relate VBN cord-282610-zim7nond 442 18 inflammatory inflammatory JJ cord-282610-zim7nond 442 19 diagnoses diagnosis NNS cord-282610-zim7nond 442 20 strengthens strengthen VBZ cord-282610-zim7nond 442 21 this this DT cord-282610-zim7nond 442 22 assumption assumption NN cord-282610-zim7nond 442 23 . . . cord-282610-zim7nond 443 1 A a DT cord-282610-zim7nond 443 2 number number NN cord-282610-zim7nond 443 3 of of IN cord-282610-zim7nond 443 4 autoantibodies autoantibody NNS cord-282610-zim7nond 443 5 have have VBP cord-282610-zim7nond 443 6 been be VBN cord-282610-zim7nond 443 7 detected detect VBN cord-282610-zim7nond 443 8 in in IN cord-282610-zim7nond 443 9 patients patient NNS cord-282610-zim7nond 443 10 with with IN cord-282610-zim7nond 443 11 ME ME NNP cord-282610-zim7nond 443 12 / / SYM cord-282610-zim7nond 443 13 CFS CFS NNP cord-282610-zim7nond 443 14 ( ( -LRB- cord-282610-zim7nond 443 15 4 4 CD cord-282610-zim7nond 443 16 ) ) -RRB- cord-282610-zim7nond 443 17 . . . cord-282610-zim7nond 444 1 This this DT cord-282610-zim7nond 444 2 has have VBZ cord-282610-zim7nond 444 3 led lead VBN cord-282610-zim7nond 444 4 some some DT cord-282610-zim7nond 444 5 research research NN cord-282610-zim7nond 444 6 teams team NNS cord-282610-zim7nond 444 7 to to TO cord-282610-zim7nond 444 8 postulate postulate VB cord-282610-zim7nond 444 9 that that IN cord-282610-zim7nond 444 10 ME ME NNP cord-282610-zim7nond 444 11 / / SYM cord-282610-zim7nond 444 12 CFS CFS NNP cord-282610-zim7nond 444 13 should should MD cord-282610-zim7nond 444 14 be be VB cord-282610-zim7nond 444 15 regarded regard VBN cord-282610-zim7nond 444 16 as as IN cord-282610-zim7nond 444 17 an an DT cord-282610-zim7nond 444 18 " " `` cord-282610-zim7nond 444 19 autoimmune autoimmune JJ cord-282610-zim7nond 444 20 " " '' cord-282610-zim7nond 444 21 disorder disorder NN cord-282610-zim7nond 444 22 ( ( -LRB- cord-282610-zim7nond 444 23 175 175 CD cord-282610-zim7nond 444 24 ) ) -RRB- cord-282610-zim7nond 444 25 . . . cord-282610-zim7nond 445 1 However however RB cord-282610-zim7nond 445 2 , , , cord-282610-zim7nond 445 3 the the DT cord-282610-zim7nond 445 4 classical classical JJ cord-282610-zim7nond 445 5 " " '' cord-282610-zim7nond 445 6 theory theory NN cord-282610-zim7nond 445 7 of of IN cord-282610-zim7nond 445 8 autoimmunity autoimmunity NN cord-282610-zim7nond 445 9 " " '' cord-282610-zim7nond 445 10 is be VBZ cord-282610-zim7nond 445 11 in in IN cord-282610-zim7nond 445 12 the the DT cord-282610-zim7nond 445 13 process process NN cord-282610-zim7nond 445 14 of of IN cord-282610-zim7nond 445 15 being be VBG cord-282610-zim7nond 445 16 re re VB cord-282610-zim7nond 445 17 - - VBN cord-282610-zim7nond 445 18 evaluated evaluate VBN cord-282610-zim7nond 445 19 ( ( -LRB- cord-282610-zim7nond 445 20 78 78 CD cord-282610-zim7nond 445 21 , , , cord-282610-zim7nond 445 22 176 176 CD cord-282610-zim7nond 445 23 ) ) -RRB- cord-282610-zim7nond 445 24 . . . cord-282610-zim7nond 446 1 Increasing increase VBG cord-282610-zim7nond 446 2 evidence evidence NN cord-282610-zim7nond 446 3 suggests suggest VBZ cord-282610-zim7nond 446 4 that that IN cord-282610-zim7nond 446 5 " " `` cord-282610-zim7nond 446 6 autoantibodies autoantibody NNS cord-282610-zim7nond 446 7 " " '' cord-282610-zim7nond 446 8 are be VBP cord-282610-zim7nond 446 9 actually actually RB cord-282610-zim7nond 446 10 created create VBN cord-282610-zim7nond 446 11 in in IN cord-282610-zim7nond 446 12 response response NN cord-282610-zim7nond 446 13 to to IN cord-282610-zim7nond 446 14 chronic chronic JJ cord-282610-zim7nond 446 15 , , , cord-282610-zim7nond 446 16 persistent persistent JJ cord-282610-zim7nond 446 17 microbiome microbiome NN cord-282610-zim7nond 446 18 pathogens pathogen NNS cord-282610-zim7nond 446 19 . . . cord-282610-zim7nond 447 1 Under under IN cord-282610-zim7nond 447 2 such such JJ cord-282610-zim7nond 447 3 conditions condition NNS cord-282610-zim7nond 447 4 molecular molecular JJ cord-282610-zim7nond 447 5 mimicry mimicry NN cord-282610-zim7nond 447 6 or or CC cord-282610-zim7nond 447 7 structural structural JJ cord-282610-zim7nond 447 8 homology homology NN cord-282610-zim7nond 447 9 between between IN cord-282610-zim7nond 447 10 pathogen pathogen NN cord-282610-zim7nond 447 11 and and CC cord-282610-zim7nond 447 12 host host NN cord-282610-zim7nond 447 13 proteins protein NNS cord-282610-zim7nond 447 14 can can MD cord-282610-zim7nond 447 15 result result VB cord-282610-zim7nond 447 16 in in IN cord-282610-zim7nond 447 17 " " `` cord-282610-zim7nond 447 18 collateral collateral JJ cord-282610-zim7nond 447 19 damage damage NN cord-282610-zim7nond 447 20 " " '' cord-282610-zim7nond 447 21 toward toward IN cord-282610-zim7nond 447 22 human human JJ cord-282610-zim7nond 447 23 tissue tissue NN cord-282610-zim7nond 447 24 . . . cord-282610-zim7nond 448 1 For for IN cord-282610-zim7nond 448 2 example example NN cord-282610-zim7nond 448 3 , , , cord-282610-zim7nond 448 4 Vojdani Vojdani NNP cord-282610-zim7nond 448 5 et et NNP cord-282610-zim7nond 448 6 al al NNP cord-282610-zim7nond 448 7 . . . cord-282610-zim7nond 449 1 ( ( -LRB- cord-282610-zim7nond 449 2 177 177 CD cord-282610-zim7nond 449 3 ) ) -RRB- cord-282610-zim7nond 449 4 found find VBD cord-282610-zim7nond 449 5 that that IN cord-282610-zim7nond 449 6 25 25 CD cord-282610-zim7nond 449 7 different different JJ cord-282610-zim7nond 449 8 Alzheimer's Alzheimer's NNP cord-282610-zim7nond 449 9 - - HYPH cord-282610-zim7nond 449 10 associated associate VBN cord-282610-zim7nond 449 11 pathogens pathogen NNS cord-282610-zim7nond 449 12 or or CC cord-282610-zim7nond 449 13 their -PRON- PRP$ cord-282610-zim7nond 449 14 molecules molecule NNS cord-282610-zim7nond 449 15 could could MD cord-282610-zim7nond 449 16 react react VB cord-282610-zim7nond 449 17 with with IN cord-282610-zim7nond 449 18 antibodies antibody NNS cord-282610-zim7nond 449 19 against against IN cord-282610-zim7nond 449 20 amyloid amyloid NN cord-282610-zim7nond 449 21 beta beta NN cord-282610-zim7nond 449 22 via via IN cord-282610-zim7nond 449 23 molecular molecular JJ cord-282610-zim7nond 449 24 mimicry mimicry NN cord-282610-zim7nond 449 25 or or CC cord-282610-zim7nond 449 26 the the DT cord-282610-zim7nond 449 27 binding binding NN cord-282610-zim7nond 449 28 of of IN cord-282610-zim7nond 449 29 bacterial bacterial JJ cord-282610-zim7nond 449 30 toxins toxin NNS cord-282610-zim7nond 449 31 to to IN cord-282610-zim7nond 449 32 amyloid amyloid NN cord-282610-zim7nond 449 33 beta beta NN cord-282610-zim7nond 449 34 . . . cord-282610-zim7nond 450 1 A a DT cord-282610-zim7nond 450 2 growing grow VBG cord-282610-zim7nond 450 3 body body NN cord-282610-zim7nond 450 4 of of IN cord-282610-zim7nond 450 5 research research NN cord-282610-zim7nond 450 6 documents document NNS cord-282610-zim7nond 450 7 " " `` cord-282610-zim7nond 450 8 autoantibody autoantibody NN cord-282610-zim7nond 450 9 " " '' cord-282610-zim7nond 450 10 production production NN cord-282610-zim7nond 450 11 in in IN cord-282610-zim7nond 450 12 response response NN cord-282610-zim7nond 450 13 to to IN cord-282610-zim7nond 450 14 a a DT cord-282610-zim7nond 450 15 range range NN cord-282610-zim7nond 450 16 of of IN cord-282610-zim7nond 450 17 bacterial bacterial JJ cord-282610-zim7nond 450 18 , , , cord-282610-zim7nond 450 19 viral viral JJ cord-282610-zim7nond 450 20 and and CC cord-282610-zim7nond 450 21 fungal fungal JJ cord-282610-zim7nond 450 22 pathogens pathogen NNS cord-282610-zim7nond 450 23 / / SYM cord-282610-zim7nond 450 24 pathobionts pathobiont NNS cord-282610-zim7nond 450 25 . . . cord-282610-zim7nond 451 1 These these DT cord-282610-zim7nond 451 2 pathogens pathogen NNS cord-282610-zim7nond 451 3 are be VBP cord-282610-zim7nond 451 4 not not RB cord-282610-zim7nond 451 5 shortterm shortterm JJ cord-282610-zim7nond 451 6 " " `` cord-282610-zim7nond 451 7 triggers trigger NNS cord-282610-zim7nond 451 8 " " '' cord-282610-zim7nond 451 9 but but CC cord-282610-zim7nond 451 10 persist persist VB cord-282610-zim7nond 451 11 as as IN cord-282610-zim7nond 451 12 members member NNS cord-282610-zim7nond 451 13 of of IN cord-282610-zim7nond 451 14 complex complex JJ cord-282610-zim7nond 451 15 microbiome microbiome NN cord-282610-zim7nond 451 16 communities community NNS cord-282610-zim7nond 451 17 . . . cord-282610-zim7nond 452 1 For for IN cord-282610-zim7nond 452 2 example example NN cord-282610-zim7nond 452 3 , , , cord-282610-zim7nond 452 4 " " `` cord-282610-zim7nond 452 5 autoantibody autoantibody NNP cord-282610-zim7nond 452 6 " " '' cord-282610-zim7nond 452 7 production production NN cord-282610-zim7nond 452 8 was be VBD cord-282610-zim7nond 452 9 recently recently RB cord-282610-zim7nond 452 10 tied tie VBN cord-282610-zim7nond 452 11 to to IN cord-282610-zim7nond 452 12 microbiome microbiome NN cord-282610-zim7nond 452 13 pathobiont pathobiont NNP cord-282610-zim7nond 452 14 Enterococcus Enterococcus NNP cord-282610-zim7nond 452 15 gallinarum gallinarum NN cord-282610-zim7nond 452 16 . . . cord-282610-zim7nond 453 1 Manfredo Manfredo NNP cord-282610-zim7nond 453 2 et et NNP cord-282610-zim7nond 453 3 al al NNP cord-282610-zim7nond 453 4 . . . cord-282610-zim7nond 454 1 ( ( -LRB- cord-282610-zim7nond 454 2 178 178 CD cord-282610-zim7nond 454 3 ) ) -RRB- cord-282610-zim7nond 454 4 detected detect VBD cord-282610-zim7nond 454 5 E. E. NNP cord-282610-zim7nond 454 6 galinarum galinarum NN cord-282610-zim7nond 454 7 in in IN cord-282610-zim7nond 454 8 the the DT cord-282610-zim7nond 454 9 mesenteric mesenteric JJ cord-282610-zim7nond 454 10 veins vein NNS cord-282610-zim7nond 454 11 , , , cord-282610-zim7nond 454 12 lymph lymph NN cord-282610-zim7nond 454 13 nodes node NNS cord-282610-zim7nond 454 14 , , , cord-282610-zim7nond 454 15 spleens spleen NNS cord-282610-zim7nond 454 16 and and CC cord-282610-zim7nond 454 17 livers liver NNS cord-282610-zim7nond 454 18 of of IN cord-282610-zim7nond 454 19 mice mouse NNS cord-282610-zim7nond 454 20 made make VBD cord-282610-zim7nond 454 21 genetically genetically RB cord-282610-zim7nond 454 22 prone prone JJ cord-282610-zim7nond 454 23 to to IN cord-282610-zim7nond 454 24 autoimmunity autoimmunity NN cord-282610-zim7nond 454 25 . . . cord-282610-zim7nond 455 1 In in IN cord-282610-zim7nond 455 2 these these DT cord-282610-zim7nond 455 3 mice mouse NNS cord-282610-zim7nond 455 4 , , , cord-282610-zim7nond 455 5 the the DT cord-282610-zim7nond 455 6 bacterium bacterium NN cord-282610-zim7nond 455 7 initiated initiate VBD cord-282610-zim7nond 455 8 the the DT cord-282610-zim7nond 455 9 production production NN cord-282610-zim7nond 455 10 of of IN cord-282610-zim7nond 455 11 " " `` cord-282610-zim7nond 455 12 autoantibodies autoantibody NNS cord-282610-zim7nond 455 13 , , , cord-282610-zim7nond 455 14 " " '' cord-282610-zim7nond 455 15 inflammation inflammation NN cord-282610-zim7nond 455 16 and and CC cord-282610-zim7nond 455 17 activated activate VBD cord-282610-zim7nond 455 18 T t NN cord-282610-zim7nond 455 19 cells cell NNS cord-282610-zim7nond 455 20 . . . cord-282610-zim7nond 456 1 However however RB cord-282610-zim7nond 456 2 , , , cord-282610-zim7nond 456 3 this this DT cord-282610-zim7nond 456 4 " " `` cord-282610-zim7nond 456 5 autoantibody autoantibody NN cord-282610-zim7nond 456 6 " " '' cord-282610-zim7nond 456 7 production production NN cord-282610-zim7nond 456 8 stopped stop VBD cord-282610-zim7nond 456 9 when when WRB cord-282610-zim7nond 456 10 E. E. NNP cord-282610-zim7nond 456 11 gallinarum gallinarum NNP cord-282610-zim7nond 456 12 's 's POS cord-282610-zim7nond 456 13 growth growth NN cord-282610-zim7nond 456 14 was be VBD cord-282610-zim7nond 456 15 suppressed suppress VBN cord-282610-zim7nond 456 16 with with IN cord-282610-zim7nond 456 17 the the DT cord-282610-zim7nond 456 18 antibiotic antibiotic JJ cord-282610-zim7nond 456 19 vancomycin vancomycin NN cord-282610-zim7nond 456 20 or or CC cord-282610-zim7nond 456 21 with with IN cord-282610-zim7nond 456 22 an an DT cord-282610-zim7nond 456 23 intramuscular intramuscular JJ cord-282610-zim7nond 456 24 vaccine vaccine NN cord-282610-zim7nond 456 25 . . . cord-282610-zim7nond 457 1 In in IN cord-282610-zim7nond 457 2 addition addition NN cord-282610-zim7nond 457 3 , , , cord-282610-zim7nond 457 4 E. E. NNP cord-282610-zim7nond 457 5 gallinarum gallinarum NNP cord-282610-zim7nond 457 6 - - HYPH cord-282610-zim7nond 457 7 specific specific JJ cord-282610-zim7nond 457 8 DNA dna NN cord-282610-zim7nond 457 9 was be VBD cord-282610-zim7nond 457 10 recovered recover VBN cord-282610-zim7nond 457 11 from from IN cord-282610-zim7nond 457 12 liver liver NN cord-282610-zim7nond 457 13 biopsies biopsy NNS cord-282610-zim7nond 457 14 of of IN cord-282610-zim7nond 457 15 human human JJ cord-282610-zim7nond 457 16 autoimmune autoimmune JJ cord-282610-zim7nond 457 17 patients patient NNS cord-282610-zim7nond 457 18 , , , cord-282610-zim7nond 457 19 and and CC cord-282610-zim7nond 457 20 co co NNS cord-282610-zim7nond 457 21 - - NNS cord-282610-zim7nond 457 22 cultures culture NNS cord-282610-zim7nond 457 23 with with IN cord-282610-zim7nond 457 24 human human JJ cord-282610-zim7nond 457 25 hepatocytes hepatocyte NNS cord-282610-zim7nond 457 26 replicated replicate VBD cord-282610-zim7nond 457 27 the the DT cord-282610-zim7nond 457 28 murine murine JJ cord-282610-zim7nond 457 29 findings finding NNS cord-282610-zim7nond 457 30 . . . cord-282610-zim7nond 458 1 Indeed indeed RB cord-282610-zim7nond 458 2 , , , cord-282610-zim7nond 458 3 many many JJ cord-282610-zim7nond 458 4 pathogens pathogen NNS cord-282610-zim7nond 458 5 can can MD cord-282610-zim7nond 458 6 drive drive VB cord-282610-zim7nond 458 7 the the DT cord-282610-zim7nond 458 8 activated activate VBN cord-282610-zim7nond 458 9 or or CC cord-282610-zim7nond 458 10 clonal clonal JJ cord-282610-zim7nond 458 11 T T NNP cord-282610-zim7nond 458 12 cell cell NN cord-282610-zim7nond 458 13 expansion expansion NN cord-282610-zim7nond 458 14 often often RB cord-282610-zim7nond 458 15 associated associate VBN cord-282610-zim7nond 458 16 with with IN cord-282610-zim7nond 458 17 " " `` cord-282610-zim7nond 458 18 autoimmune autoimmune JJ cord-282610-zim7nond 458 19 " " '' cord-282610-zim7nond 458 20 conditions condition NNS cord-282610-zim7nond 458 21 . . . cord-282610-zim7nond 459 1 For for IN cord-282610-zim7nond 459 2 example example NN cord-282610-zim7nond 459 3 , , , cord-282610-zim7nond 459 4 Tuffs Tuffs NNP cord-282610-zim7nond 459 5 et et NNP cord-282610-zim7nond 459 6 al al NNP cord-282610-zim7nond 459 7 . . . cord-282610-zim7nond 460 1 ( ( -LRB- cord-282610-zim7nond 460 2 179 179 CD cord-282610-zim7nond 460 3 ) ) -RRB- cord-282610-zim7nond 460 4 found find VBD cord-282610-zim7nond 460 5 that that IN cord-282610-zim7nond 460 6 S. S. NNP cord-282610-zim7nond 460 7 aureus aureus NN cord-282610-zim7nond 460 8 endotoxins endotoxin NNS cord-282610-zim7nond 460 9 triggered trigger VBD cord-282610-zim7nond 460 10 uncontrolled uncontrolled JJ cord-282610-zim7nond 460 11 activation activation NN cord-282610-zim7nond 460 12 of of IN cord-282610-zim7nond 460 13 T t NN cord-282610-zim7nond 460 14 cells cell NNS cord-282610-zim7nond 460 15 . . . cord-282610-zim7nond 461 1 This this DT cord-282610-zim7nond 461 2 led lead VBD cord-282610-zim7nond 461 3 to to IN cord-282610-zim7nond 461 4 a a DT cord-282610-zim7nond 461 5 proinflammatory proinflammatory JJ cord-282610-zim7nond 461 6 cytokine cytokine NN cord-282610-zim7nond 461 7 storm storm NN cord-282610-zim7nond 461 8 that that WDT cord-282610-zim7nond 461 9 accounted account VBD cord-282610-zim7nond 461 10 for for IN cord-282610-zim7nond 461 11 both both CC cord-282610-zim7nond 461 12 T T NNP cord-282610-zim7nond 461 13 cell cell NN cord-282610-zim7nond 461 14 activation activation NN cord-282610-zim7nond 461 15 and and CC cord-282610-zim7nond 461 16 related related JJ cord-282610-zim7nond 461 17 inflammation inflammation NN cord-282610-zim7nond 461 18 . . . cord-282610-zim7nond 462 1 Microbes microbe NNS cord-282610-zim7nond 462 2 and and CC cord-282610-zim7nond 462 3 their -PRON- PRP$ cord-282610-zim7nond 462 4 metabolites metabolite NNS cord-282610-zim7nond 462 5 control control VBP cord-282610-zim7nond 462 6 bidirectional bidirectional JJ cord-282610-zim7nond 462 7 signaling signaling NN cord-282610-zim7nond 462 8 between between IN cord-282610-zim7nond 462 9 the the DT cord-282610-zim7nond 462 10 gut gut NN cord-282610-zim7nond 462 11 and and CC cord-282610-zim7nond 462 12 the the DT cord-282610-zim7nond 462 13 brain brain NN cord-282610-zim7nond 462 14 via via IN cord-282610-zim7nond 462 15 pathways pathway NNS cord-282610-zim7nond 462 16 collectively collectively RB cord-282610-zim7nond 462 17 known know VBN cord-282610-zim7nond 462 18 as as IN cord-282610-zim7nond 462 19 the the DT cord-282610-zim7nond 462 20 gut gut NN cord-282610-zim7nond 462 21 - - HYPH cord-282610-zim7nond 462 22 brain brain NN cord-282610-zim7nond 462 23 axis axis NN cord-282610-zim7nond 462 24 ( ( -LRB- cord-282610-zim7nond 462 25 180 180 CD cord-282610-zim7nond 462 26 ) ) -RRB- cord-282610-zim7nond 462 27 . . . cord-282610-zim7nond 463 1 The the DT cord-282610-zim7nond 463 2 gut gut NN cord-282610-zim7nond 463 3 - - HYPH cord-282610-zim7nond 463 4 brain brain NN cord-282610-zim7nond 463 5 axis axis NN cord-282610-zim7nond 463 6 involves involve VBZ cord-282610-zim7nond 463 7 various various JJ cord-282610-zim7nond 463 8 afferent afferent NN cord-282610-zim7nond 463 9 and and CC cord-282610-zim7nond 463 10 efferent efferent JJ cord-282610-zim7nond 463 11 pathways pathway NNS cord-282610-zim7nond 463 12 including include VBG cord-282610-zim7nond 463 13 the the DT cord-282610-zim7nond 463 14 vagus vagus NN cord-282610-zim7nond 463 15 nerve nerve NN cord-282610-zim7nond 463 16 , , , cord-282610-zim7nond 463 17 with with IN cord-282610-zim7nond 463 18 signaling signal VBG cord-282610-zim7nond 463 19 impacting impact VBG cord-282610-zim7nond 463 20 neural neural JJ cord-282610-zim7nond 463 21 , , , cord-282610-zim7nond 463 22 endocrine endocrine NN cord-282610-zim7nond 463 23 , , , cord-282610-zim7nond 463 24 and and CC cord-282610-zim7nond 463 25 immune immune JJ cord-282610-zim7nond 463 26 processes process NNS cord-282610-zim7nond 463 27 . . . cord-282610-zim7nond 464 1 The the DT cord-282610-zim7nond 464 2 gut gut NN cord-282610-zim7nond 464 3 's 's POS cord-282610-zim7nond 464 4 enteric enteric JJ cord-282610-zim7nond 464 5 nervous nervous JJ cord-282610-zim7nond 464 6 system system NN cord-282610-zim7nond 464 7 contains contain VBZ cord-282610-zim7nond 464 8 over over IN cord-282610-zim7nond 464 9 100 100 CD cord-282610-zim7nond 464 10 million million CD cord-282610-zim7nond 464 11 neurons neuron NNS cord-282610-zim7nond 464 12 - - : cord-282610-zim7nond 464 13 more more JJR cord-282610-zim7nond 464 14 than than IN cord-282610-zim7nond 464 15 in in IN cord-282610-zim7nond 464 16 either either CC cord-282610-zim7nond 464 17 the the DT cord-282610-zim7nond 464 18 peripheral peripheral JJ cord-282610-zim7nond 464 19 nervous nervous JJ cord-282610-zim7nond 464 20 system system NN cord-282610-zim7nond 464 21 or or CC cord-282610-zim7nond 464 22 spinal spinal JJ cord-282610-zim7nond 464 23 cord cord NN cord-282610-zim7nond 464 24 ( ( -LRB- cord-282610-zim7nond 464 25 181 181 CD cord-282610-zim7nond 464 26 ) ) -RRB- cord-282610-zim7nond 464 27 . . . cord-282610-zim7nond 465 1 It -PRON- PRP cord-282610-zim7nond 465 2 follows follow VBZ cord-282610-zim7nond 465 3 that that DT cord-282610-zim7nond 465 4 gut gut NN cord-282610-zim7nond 465 5 microbiome microbiome NN cord-282610-zim7nond 465 6 dysbiosis dysbiosis NN cord-282610-zim7nond 465 7 may may MD cord-282610-zim7nond 465 8 modulate modulate VB cord-282610-zim7nond 465 9 brain brain NN cord-282610-zim7nond 465 10 activity activity NN cord-282610-zim7nond 465 11 . . . cord-282610-zim7nond 466 1 For for IN cord-282610-zim7nond 466 2 example example NN cord-282610-zim7nond 466 3 , , , cord-282610-zim7nond 466 4 Sampson Sampson NNP cord-282610-zim7nond 466 5 et et NNP cord-282610-zim7nond 466 6 al al NNP cord-282610-zim7nond 466 7 . . . cord-282610-zim7nond 467 1 ( ( -LRB- cord-282610-zim7nond 467 2 79 79 CD cord-282610-zim7nond 467 3 ) ) -RRB- cord-282610-zim7nond 467 4 transplanted transplant VBN cord-282610-zim7nond 467 5 fecal fecal JJ cord-282610-zim7nond 467 6 samples sample NNS cord-282610-zim7nond 467 7 from from IN cord-282610-zim7nond 467 8 patients patient NNS cord-282610-zim7nond 467 9 with with IN cord-282610-zim7nond 467 10 Parkinson Parkinson NNP cord-282610-zim7nond 467 11 's 's POS cord-282610-zim7nond 467 12 disease disease NN cord-282610-zim7nond 467 13 into into IN cord-282610-zim7nond 467 14 germ germ NN cord-282610-zim7nond 467 15 - - HYPH cord-282610-zim7nond 467 16 free free JJ cord-282610-zim7nond 467 17 mice mouse NNS cord-282610-zim7nond 467 18 . . . cord-282610-zim7nond 468 1 These these DT cord-282610-zim7nond 468 2 mice mouse NNS cord-282610-zim7nond 468 3 , , , cord-282610-zim7nond 468 4 and and CC cord-282610-zim7nond 468 5 not not RB cord-282610-zim7nond 468 6 controls control NNS cord-282610-zim7nond 468 7 , , , cord-282610-zim7nond 468 8 exhibited exhibit VBD cord-282610-zim7nond 468 9 physical physical JJ cord-282610-zim7nond 468 10 symptoms symptom NNS cord-282610-zim7nond 468 11 associated associate VBN cord-282610-zim7nond 468 12 with with IN cord-282610-zim7nond 468 13 Parkinson Parkinson NNP cord-282610-zim7nond 468 14 's 's POS cord-282610-zim7nond 468 15 . . . cord-282610-zim7nond 469 1 However however RB cord-282610-zim7nond 469 2 , , , cord-282610-zim7nond 469 3 there there EX cord-282610-zim7nond 469 4 is be VBZ cord-282610-zim7nond 469 5 also also RB cord-282610-zim7nond 469 6 growing grow VBG cord-282610-zim7nond 469 7 evidence evidence NN cord-282610-zim7nond 469 8 that that IN cord-282610-zim7nond 469 9 humans human NNS cord-282610-zim7nond 469 10 may may MD cord-282610-zim7nond 469 11 harbor harbor VB cord-282610-zim7nond 469 12 a a DT cord-282610-zim7nond 469 13 brain brain NN cord-282610-zim7nond 469 14 microbiome microbiome NN cord-282610-zim7nond 469 15 . . . cord-282610-zim7nond 470 1 Researchers researcher NNS cord-282610-zim7nond 470 2 at at IN cord-282610-zim7nond 470 3 Harvard Harvard NNP cord-282610-zim7nond 470 4 University University NNP cord-282610-zim7nond 470 5 are be VBP cord-282610-zim7nond 470 6 characterizing characterize VBG cord-282610-zim7nond 470 7 this this DT cord-282610-zim7nond 470 8 ecosystem ecosystem NN cord-282610-zim7nond 470 9 as as IN cord-282610-zim7nond 470 10 part part NN cord-282610-zim7nond 470 11 of of IN cord-282610-zim7nond 470 12 the the DT cord-282610-zim7nond 470 13 ongoing ongoing JJ cord-282610-zim7nond 470 14 " " `` cord-282610-zim7nond 470 15 Brain Brain NNP cord-282610-zim7nond 470 16 Microbiome Microbiome NNP cord-282610-zim7nond 470 17 Project Project NNP cord-282610-zim7nond 470 18 . . . cord-282610-zim7nond 470 19 " " '' cord-282610-zim7nond 471 1 In in IN cord-282610-zim7nond 471 2 what what WP cord-282610-zim7nond 471 3 marks mark VBZ cord-282610-zim7nond 471 4 a a DT cord-282610-zim7nond 471 5 major major JJ cord-282610-zim7nond 471 6 paradigm paradigm NN cord-282610-zim7nond 471 7 shift shift NN cord-282610-zim7nond 471 8 , , , cord-282610-zim7nond 471 9 multiple multiple JJ cord-282610-zim7nond 471 10 research research NN cord-282610-zim7nond 471 11 teams team NNS cord-282610-zim7nond 471 12 have have VBP cord-282610-zim7nond 471 13 shown show VBN cord-282610-zim7nond 471 14 that that IN cord-282610-zim7nond 471 15 both both DT cord-282610-zim7nond 471 16 amyloid amyloid NN cord-282610-zim7nond 471 17 beta beta NN cord-282610-zim7nond 471 18 and and CC cord-282610-zim7nond 471 19 prion prion NN cord-282610-zim7nond 471 20 protein protein NN cord-282610-zim7nond 471 21 ( ( -LRB- cord-282610-zim7nond 471 22 PrP prp NN cord-282610-zim7nond 471 23 ) ) -RRB- cord-282610-zim7nond 471 24 are be VBP cord-282610-zim7nond 471 25 potent potent JJ cord-282610-zim7nond 471 26 antimicrobial antimicrobial JJ cord-282610-zim7nond 471 27 peptides peptide NNS cord-282610-zim7nond 471 28 ( ( -LRB- cord-282610-zim7nond 471 29 182 182 CD cord-282610-zim7nond 471 30 , , , cord-282610-zim7nond 471 31 183 183 CD cord-282610-zim7nond 471 32 ) ) -RRB- cord-282610-zim7nond 471 33 . . . cord-282610-zim7nond 472 1 Amyloid amyloid NN cord-282610-zim7nond 472 2 beta beta NN cord-282610-zim7nond 472 3 exhibited exhibit VBD cord-282610-zim7nond 472 4 antimicrobial antimicrobial JJ cord-282610-zim7nond 472 5 activity activity NN cord-282610-zim7nond 472 6 against against IN cord-282610-zim7nond 472 7 a a DT cord-282610-zim7nond 472 8 range range NN cord-282610-zim7nond 472 9 of of IN cord-282610-zim7nond 472 10 common common JJ cord-282610-zim7nond 472 11 microorganisms microorganism NNS cord-282610-zim7nond 472 12 with with IN cord-282610-zim7nond 472 13 a a DT cord-282610-zim7nond 472 14 potency potency NN cord-282610-zim7nond 472 15 equivalent equivalent NN cord-282610-zim7nond 472 16 to to IN cord-282610-zim7nond 472 17 , , , cord-282610-zim7nond 472 18 and and CC cord-282610-zim7nond 472 19 in in IN cord-282610-zim7nond 472 20 some some DT cord-282610-zim7nond 472 21 cases case NNS cord-282610-zim7nond 472 22 greater great JJR cord-282610-zim7nond 472 23 than than IN cord-282610-zim7nond 472 24 , , , cord-282610-zim7nond 472 25 cathelicidin cathelicidin NNP cord-282610-zim7nond 472 26 ( ( -LRB- cord-282610-zim7nond 472 27 LL-37 LL-37 NNP cord-282610-zim7nond 472 28 ) ) -RRB- cord-282610-zim7nond 472 29 ( ( -LRB- cord-282610-zim7nond 472 30 184 184 CD cord-282610-zim7nond 472 31 ) ) -RRB- cord-282610-zim7nond 472 32 . . . cord-282610-zim7nond 473 1 These these DT cord-282610-zim7nond 473 2 pathogens pathogen NNS cord-282610-zim7nond 473 3 included include VBD cord-282610-zim7nond 473 4 S. S. NNP cord-282610-zim7nond 473 5 typhimurium typhimurium NN cord-282610-zim7nond 473 6 , , , cord-282610-zim7nond 473 7 Candida Candida NNP cord-282610-zim7nond 473 8 albicans albican NNS cord-282610-zim7nond 473 9 and and CC cord-282610-zim7nond 473 10 , , , cord-282610-zim7nond 473 11 more more RBR cord-282610-zim7nond 473 12 recently recently RB cord-282610-zim7nond 473 13 , , , cord-282610-zim7nond 473 14 a a DT cord-282610-zim7nond 473 15 number number NN cord-282610-zim7nond 473 16 of of IN cord-282610-zim7nond 473 17 herpesviruses herpesviruse NNS cord-282610-zim7nond 473 18 capable capable JJ cord-282610-zim7nond 473 19 of of IN cord-282610-zim7nond 473 20 persisting persist VBG cord-282610-zim7nond 473 21 in in IN cord-282610-zim7nond 473 22 the the DT cord-282610-zim7nond 473 23 Alzheimer Alzheimer NNP cord-282610-zim7nond 473 24 's 's POS cord-282610-zim7nond 473 25 brain brain NN cord-282610-zim7nond 473 26 ( ( -LRB- cord-282610-zim7nond 473 27 88 88 CD cord-282610-zim7nond 473 28 , , , cord-282610-zim7nond 473 29 185 185 CD cord-282610-zim7nond 473 30 ) ) -RRB- cord-282610-zim7nond 473 31 . . . cord-282610-zim7nond 474 1 The the DT cord-282610-zim7nond 474 2 findings finding NNS cord-282610-zim7nond 474 3 strongly strongly RB cord-282610-zim7nond 474 4 suggest suggest VBP cord-282610-zim7nond 474 5 that that IN cord-282610-zim7nond 474 6 amyloid amyloid NN cord-282610-zim7nond 474 7 beta beta NN cord-282610-zim7nond 474 8 and and CC cord-282610-zim7nond 474 9 PrP prp NN cord-282610-zim7nond 474 10 are be VBP cord-282610-zim7nond 474 11 not not RB cord-282610-zim7nond 474 12 useless useless JJ cord-282610-zim7nond 474 13 byproducts byproduct NNS cord-282610-zim7nond 474 14 of of IN cord-282610-zim7nond 474 15 abnormal abnormal JJ cord-282610-zim7nond 474 16 brain brain NN cord-282610-zim7nond 474 17 catabolism catabolism NN cord-282610-zim7nond 474 18 . . . cord-282610-zim7nond 475 1 Rather rather RB cord-282610-zim7nond 475 2 , , , cord-282610-zim7nond 475 3 they -PRON- PRP cord-282610-zim7nond 475 4 appear appear VBP cord-282610-zim7nond 475 5 to to TO cord-282610-zim7nond 475 6 form form VB cord-282610-zim7nond 475 7 a a DT cord-282610-zim7nond 475 8 mediated mediate VBN cord-282610-zim7nond 475 9 response response NN cord-282610-zim7nond 475 10 of of IN cord-282610-zim7nond 475 11 the the DT cord-282610-zim7nond 475 12 innate innate JJ cord-282610-zim7nond 475 13 immune immune JJ cord-282610-zim7nond 475 14 system system NN cord-282610-zim7nond 475 15 toward toward IN cord-282610-zim7nond 475 16 infectious infectious JJ cord-282610-zim7nond 475 17 agents agent NNS cord-282610-zim7nond 475 18 in in IN cord-282610-zim7nond 475 19 brain brain NN cord-282610-zim7nond 475 20 tissue tissue NN cord-282610-zim7nond 475 21 ( ( -LRB- cord-282610-zim7nond 475 22 186 186 CD cord-282610-zim7nond 475 23 ) ) -RRB- cord-282610-zim7nond 475 24 . . . cord-282610-zim7nond 476 1 A a DT cord-282610-zim7nond 476 2 number number NN cord-282610-zim7nond 476 3 of of IN cord-282610-zim7nond 476 4 brain brain NN cord-282610-zim7nond 476 5 abnormalities abnormality NNS cord-282610-zim7nond 476 6 have have VBP cord-282610-zim7nond 476 7 been be VBN cord-282610-zim7nond 476 8 reported report VBN cord-282610-zim7nond 476 9 in in IN cord-282610-zim7nond 476 10 patents patent NNS cord-282610-zim7nond 476 11 with with IN cord-282610-zim7nond 476 12 ME ME NNP cord-282610-zim7nond 476 13 / / SYM cord-282610-zim7nond 476 14 CFS CFS NNP cord-282610-zim7nond 476 15 ( ( -LRB- cord-282610-zim7nond 476 16 187 187 CD cord-282610-zim7nond 476 17 ) ) -RRB- cord-282610-zim7nond 476 18 . . . cord-282610-zim7nond 477 1 These these DT cord-282610-zim7nond 477 2 findings finding NNS cord-282610-zim7nond 477 3 must must MD cord-282610-zim7nond 477 4 be be VB cord-282610-zim7nond 477 5 interpreted interpret VBN cord-282610-zim7nond 477 6 in in IN cord-282610-zim7nond 477 7 light light NN cord-282610-zim7nond 477 8 of of IN cord-282610-zim7nond 477 9 these these DT cord-282610-zim7nond 477 10 novel novel JJ cord-282610-zim7nond 477 11 infection infection NN cord-282610-zim7nond 477 12 - - HYPH cord-282610-zim7nond 477 13 based base VBN cord-282610-zim7nond 477 14 paradigms paradigm NNS cord-282610-zim7nond 477 15 and and CC cord-282610-zim7nond 477 16 in in IN cord-282610-zim7nond 477 17 concert concert NN cord-282610-zim7nond 477 18 with with IN cord-282610-zim7nond 477 19 emerging emerge VBG cord-282610-zim7nond 477 20 data datum NNS cord-282610-zim7nond 477 21 on on IN cord-282610-zim7nond 477 22 the the DT cord-282610-zim7nond 477 23 brain brain NN cord-282610-zim7nond 477 24 microbiome microbiome NN cord-282610-zim7nond 477 25 . . . cord-282610-zim7nond 478 1 In in IN cord-282610-zim7nond 478 2 a a DT cord-282610-zim7nond 478 3 study study NN cord-282610-zim7nond 478 4 of of IN cord-282610-zim7nond 478 5 aortic aortic JJ cord-282610-zim7nond 478 6 aneurysms aneurysm NNS cord-282610-zim7nond 478 7 , , , cord-282610-zim7nond 478 8 Gottlieb Gottlieb NNP cord-282610-zim7nond 478 9 et et NNP cord-282610-zim7nond 478 10 al al NNP cord-282610-zim7nond 478 11 . . . cord-282610-zim7nond 479 1 ( ( -LRB- cord-282610-zim7nond 479 2 188 188 CD cord-282610-zim7nond 479 3 ) ) -RRB- cord-282610-zim7nond 479 4 reported report VBD cord-282610-zim7nond 479 5 that that IN cord-282610-zim7nond 479 6 BAK1 BAK1 NNP cord-282610-zim7nond 479 7 SNP SNP NNP cord-282610-zim7nond 479 8 - - HYPH cord-282610-zim7nond 479 9 containing contain VBG cord-282610-zim7nond 479 10 alleles allele NNS cord-282610-zim7nond 479 11 were be VBD cord-282610-zim7nond 479 12 detected detect VBN cord-282610-zim7nond 479 13 in in IN cord-282610-zim7nond 479 14 aortic aortic JJ cord-282610-zim7nond 479 15 tissue tissue NN cord-282610-zim7nond 479 16 but but CC cord-282610-zim7nond 479 17 not not RB cord-282610-zim7nond 479 18 in in IN cord-282610-zim7nond 479 19 blood blood NN cord-282610-zim7nond 479 20 samples sample NNS cord-282610-zim7nond 479 21 from from IN cord-282610-zim7nond 479 22 the the DT cord-282610-zim7nond 479 23 same same JJ cord-282610-zim7nond 479 24 patients patient NNS cord-282610-zim7nond 479 25 . . . cord-282610-zim7nond 480 1 More more RBR cord-282610-zim7nond 480 2 recently recently RB cord-282610-zim7nond 480 3 Ursini Ursini NNP cord-282610-zim7nond 480 4 et et NNP cord-282610-zim7nond 480 5 al al NNP cord-282610-zim7nond 480 6 . . . cord-282610-zim7nond 481 1 ( ( -LRB- cord-282610-zim7nond 481 2 189 189 CD cord-282610-zim7nond 481 3 ) ) -RRB- cord-282610-zim7nond 481 4 found find VBD cord-282610-zim7nond 481 5 that that IN cord-282610-zim7nond 481 6 schizophrenia schizophrenia NN cord-282610-zim7nond 481 7 gene gene NN cord-282610-zim7nond 481 8 risk risk NN cord-282610-zim7nond 481 9 loci locus NNS cord-282610-zim7nond 481 10 that that WDT cord-282610-zim7nond 481 11 interact interact VBP cord-282610-zim7nond 481 12 with with IN cord-282610-zim7nond 481 13 early early JJ cord-282610-zim7nond 481 14 - - HYPH cord-282610-zim7nond 481 15 life life NN cord-282610-zim7nond 481 16 complications complication NNS cord-282610-zim7nond 481 17 are be VBP cord-282610-zim7nond 481 18 highly highly RB cord-282610-zim7nond 481 19 expressed express VBN cord-282610-zim7nond 481 20 in in IN cord-282610-zim7nond 481 21 the the DT cord-282610-zim7nond 481 22 placenta placenta NN cord-282610-zim7nond 481 23 . . . cord-282610-zim7nond 482 1 However however RB cord-282610-zim7nond 482 2 , , , cord-282610-zim7nond 482 3 these these DT cord-282610-zim7nond 482 4 loci locus NNS cord-282610-zim7nond 482 5 were be VBD cord-282610-zim7nond 482 6 differentially differentially RB cord-282610-zim7nond 482 7 expressed express VBN cord-282610-zim7nond 482 8 in in IN cord-282610-zim7nond 482 9 placentas placenta NNS cord-282610-zim7nond 482 10 from from IN cord-282610-zim7nond 482 11 women woman NNS cord-282610-zim7nond 482 12 who who WP cord-282610-zim7nond 482 13 suffered suffer VBD cord-282610-zim7nond 482 14 complications complication NNS cord-282610-zim7nond 482 15 during during IN cord-282610-zim7nond 482 16 pregnancy pregnancy NN cord-282610-zim7nond 482 17 . . . cord-282610-zim7nond 483 1 They -PRON- PRP cord-282610-zim7nond 483 2 were be VBD cord-282610-zim7nond 483 3 also also RB cord-282610-zim7nond 483 4 differentially differentially RB cord-282610-zim7nond 483 5 upregulated upregulate VBN cord-282610-zim7nond 483 6 in in IN cord-282610-zim7nond 483 7 placentae placentae NN cord-282610-zim7nond 483 8 from from IN cord-282610-zim7nond 483 9 male male NN cord-282610-zim7nond 483 10 compared compare VBN cord-282610-zim7nond 483 11 with with IN cord-282610-zim7nond 483 12 female female JJ cord-282610-zim7nond 483 13 offspring offspring NN cord-282610-zim7nond 483 14 . . . cord-282610-zim7nond 484 1 These these DT cord-282610-zim7nond 484 2 and and CC cord-282610-zim7nond 484 3 related related JJ cord-282610-zim7nond 484 4 findings finding NNS cord-282610-zim7nond 484 5 strongly strongly RB cord-282610-zim7nond 484 6 suggest suggest VBP cord-282610-zim7nond 484 7 that that IN cord-282610-zim7nond 484 8 the the DT cord-282610-zim7nond 484 9 environment environment NN cord-282610-zim7nond 484 10 can can MD cord-282610-zim7nond 484 11 select select VB cord-282610-zim7nond 484 12 for for IN cord-282610-zim7nond 484 13 human human JJ cord-282610-zim7nond 484 14 genome genome NN cord-282610-zim7nond 484 15 activity activity NN cord-282610-zim7nond 484 16 . . . cord-282610-zim7nond 485 1 For for IN cord-282610-zim7nond 485 2 example example NN cord-282610-zim7nond 485 3 , , , cord-282610-zim7nond 485 4 Harley Harley NNP cord-282610-zim7nond 485 5 et et NNP cord-282610-zim7nond 485 6 al al NNP cord-282610-zim7nond 485 7 . . . cord-282610-zim7nond 486 1 ( ( -LRB- cord-282610-zim7nond 486 2 190 190 CD cord-282610-zim7nond 486 3 ) ) -RRB- cord-282610-zim7nond 486 4 found find VBD cord-282610-zim7nond 486 5 that that IN cord-282610-zim7nond 486 6 in in IN cord-282610-zim7nond 486 7 EBV EBV NNP cord-282610-zim7nond 486 8 infected infected JJ cord-282610-zim7nond 486 9 cells cell NNS cord-282610-zim7nond 486 10 , , , cord-282610-zim7nond 486 11 EBNA2 EBNA2 NNS cord-282610-zim7nond 486 12 and and CC cord-282610-zim7nond 486 13 its -PRON- PRP$ cord-282610-zim7nond 486 14 transcription transcription NN cord-282610-zim7nond 486 15 factors factor NNS cord-282610-zim7nond 486 16 modulated modulate VBD cord-282610-zim7nond 486 17 the the DT cord-282610-zim7nond 486 18 activity activity NN cord-282610-zim7nond 486 19 of of IN cord-282610-zim7nond 486 20 human human JJ cord-282610-zim7nond 486 21 genes gene NNS cord-282610-zim7nond 486 22 associated associate VBN cord-282610-zim7nond 486 23 with with IN cord-282610-zim7nond 486 24 risk risk NN cord-282610-zim7nond 486 25 for for IN cord-282610-zim7nond 486 26 multiple multiple JJ cord-282610-zim7nond 486 27 sclerosis sclerosis NN cord-282610-zim7nond 486 28 , , , cord-282610-zim7nond 486 29 rheumatoid rheumatoid NN cord-282610-zim7nond 486 30 arthritis arthritis NN cord-282610-zim7nond 486 31 , , , cord-282610-zim7nond 486 32 type type NN cord-282610-zim7nond 486 33 1 1 CD cord-282610-zim7nond 486 34 diabetes diabetes NN cord-282610-zim7nond 486 35 and and CC cord-282610-zim7nond 486 36 other other JJ cord-282610-zim7nond 486 37 conditions condition NNS cord-282610-zim7nond 486 38 . . . cord-282610-zim7nond 487 1 In in IN cord-282610-zim7nond 487 2 fact fact NN cord-282610-zim7nond 487 3 , , , cord-282610-zim7nond 487 4 nearly nearly RB cord-282610-zim7nond 487 5 half half NN cord-282610-zim7nond 487 6 of of IN cord-282610-zim7nond 487 7 systemic systemic JJ cord-282610-zim7nond 487 8 lupus lupus NN cord-282610-zim7nond 487 9 erythematosus erythematosus NN cord-282610-zim7nond 487 10 risk risk NN cord-282610-zim7nond 487 11 loci locus NNS cord-282610-zim7nond 487 12 were be VBD cord-282610-zim7nond 487 13 occupied occupy VBN cord-282610-zim7nond 487 14 by by IN cord-282610-zim7nond 487 15 EBNA2 ebna2 NN cord-282610-zim7nond 487 16 and and CC cord-282610-zim7nond 487 17 co co JJ cord-282610-zim7nond 487 18 - - JJ cord-282610-zim7nond 487 19 clustering clustering JJ cord-282610-zim7nond 487 20 human human JJ cord-282610-zim7nond 487 21 transcription transcription NN cord-282610-zim7nond 487 22 factors factor NNS cord-282610-zim7nond 487 23 . . . cord-282610-zim7nond 488 1 Studies study NNS cord-282610-zim7nond 488 2 of of IN cord-282610-zim7nond 488 3 the the DT cord-282610-zim7nond 488 4 human human JJ cord-282610-zim7nond 488 5 genome genome NN cord-282610-zim7nond 488 6 must must MD cord-282610-zim7nond 488 7 also also RB cord-282610-zim7nond 488 8 account account VB cord-282610-zim7nond 488 9 for for IN cord-282610-zim7nond 488 10 the the DT cord-282610-zim7nond 488 11 full full JJ cord-282610-zim7nond 488 12 extent extent NN cord-282610-zim7nond 488 13 of of IN cord-282610-zim7nond 488 14 microbial microbial JJ cord-282610-zim7nond 488 15 DNA DNA NNP cord-282610-zim7nond 488 16 and and CC cord-282610-zim7nond 488 17 RNA RNA NNP cord-282610-zim7nond 488 18 in in IN cord-282610-zim7nond 488 19 human human JJ cord-282610-zim7nond 488 20 tissue tissue NN cord-282610-zim7nond 488 21 and and CC cord-282610-zim7nond 488 22 blood blood NN cord-282610-zim7nond 488 23 . . . cord-282610-zim7nond 489 1 If if IN cord-282610-zim7nond 489 2 a a DT cord-282610-zim7nond 489 3 genomic genomic JJ cord-282610-zim7nond 489 4 assembler assembler NN cord-282610-zim7nond 489 5 fails fail VBZ cord-282610-zim7nond 489 6 to to TO cord-282610-zim7nond 489 7 account account VB cord-282610-zim7nond 489 8 for for IN cord-282610-zim7nond 489 9 this this DT cord-282610-zim7nond 489 10 contamination contamination NN cord-282610-zim7nond 489 11 , , , cord-282610-zim7nond 489 12 chances chance NNS cord-282610-zim7nond 489 13 of of IN cord-282610-zim7nond 489 14 a a DT cord-282610-zim7nond 489 15 false false JJ cord-282610-zim7nond 489 16 positive positive JJ cord-282610-zim7nond 489 17 single single JJ cord-282610-zim7nond 489 18 nucleotide nucleotide JJ cord-282610-zim7nond 489 19 polymorphism polymorphism NN cord-282610-zim7nond 489 20 ( ( -LRB- cord-282610-zim7nond 489 21 SNP SNP NNP cord-282610-zim7nond 489 22 ) ) -RRB- cord-282610-zim7nond 489 23 increase increase VB cord-282610-zim7nond 489 24 significantly significantly RB cord-282610-zim7nond 489 25 during during IN cord-282610-zim7nond 489 26 analysis analysis NN cord-282610-zim7nond 489 27 ( ( -LRB- cord-282610-zim7nond 489 28 191 191 CD cord-282610-zim7nond 489 29 ) ) -RRB- cord-282610-zim7nond 489 30 . . . cord-282610-zim7nond 490 1 Contamination contamination NN cord-282610-zim7nond 490 2 with with IN cord-282610-zim7nond 490 3 even even RB cord-282610-zim7nond 490 4 a a DT cord-282610-zim7nond 490 5 small small JJ cord-282610-zim7nond 490 6 amount amount NN cord-282610-zim7nond 490 7 of of IN cord-282610-zim7nond 490 8 microbial microbial JJ cord-282610-zim7nond 490 9 DNA DNA NNP cord-282610-zim7nond 490 10 / / SYM cord-282610-zim7nond 490 11 RNA RNA NNP cord-282610-zim7nond 490 12 - - : cord-282610-zim7nond 490 13 just just RB cord-282610-zim7nond 490 14 one one CD cord-282610-zim7nond 490 15 or or CC cord-282610-zim7nond 490 16 two two CD cord-282610-zim7nond 490 17 base base NN cord-282610-zim7nond 490 18 pairs pair NNS cord-282610-zim7nond 490 19 of of IN cord-282610-zim7nond 490 20 difference difference NN cord-282610-zim7nond 490 21 - - : cord-282610-zim7nond 490 22 is be VBZ cord-282610-zim7nond 490 23 enough enough JJ cord-282610-zim7nond 490 24 to to TO cord-282610-zim7nond 490 25 cause cause VB cord-282610-zim7nond 490 26 significant significant JJ cord-282610-zim7nond 490 27 statistical statistical JJ cord-282610-zim7nond 490 28 errors error NNS cord-282610-zim7nond 490 29 in in IN cord-282610-zim7nond 490 30 this this DT cord-282610-zim7nond 490 31 fashion fashion NN cord-282610-zim7nond 490 32 . . . cord-282610-zim7nond 491 1 If if IN cord-282610-zim7nond 491 2 ME ME NNP cord-282610-zim7nond 491 3 / / SYM cord-282610-zim7nond 491 4 CFS CFS NNP cord-282610-zim7nond 491 5 is be VBZ cord-282610-zim7nond 491 6 driven drive VBN cord-282610-zim7nond 491 7 by by IN cord-282610-zim7nond 491 8 successive successive JJ cord-282610-zim7nond 491 9 infection infection NN cord-282610-zim7nond 491 10 , , , cord-282610-zim7nond 491 11 treatments treatment NNS cord-282610-zim7nond 491 12 that that WDT cord-282610-zim7nond 491 13 support support VBP cord-282610-zim7nond 491 14 or or CC cord-282610-zim7nond 491 15 activate activate VB cord-282610-zim7nond 491 16 the the DT cord-282610-zim7nond 491 17 human human JJ cord-282610-zim7nond 491 18 immune immune JJ cord-282610-zim7nond 491 19 system system NN cord-282610-zim7nond 491 20 could could MD cord-282610-zim7nond 491 21 improve improve VB cord-282610-zim7nond 491 22 microbiome microbiome NN cord-282610-zim7nond 491 23 health health NN cord-282610-zim7nond 491 24 by by IN cord-282610-zim7nond 491 25 allowing allow VBG cord-282610-zim7nond 491 26 patients patient NNS cord-282610-zim7nond 491 27 to to TO cord-282610-zim7nond 491 28 better well RBR cord-282610-zim7nond 491 29 target target VB cord-282610-zim7nond 491 30 persistent persistent JJ cord-282610-zim7nond 491 31 pathogens pathogen NNS cord-282610-zim7nond 491 32 . . . cord-282610-zim7nond 492 1 Development development NN cord-282610-zim7nond 492 2 of of IN cord-282610-zim7nond 492 3 such such JJ cord-282610-zim7nond 492 4 therapies therapy NNS cord-282610-zim7nond 492 5 should should MD cord-282610-zim7nond 492 6 be be VB cord-282610-zim7nond 492 7 a a DT cord-282610-zim7nond 492 8 priority priority NN cord-282610-zim7nond 492 9 for for IN cord-282610-zim7nond 492 10 the the DT cord-282610-zim7nond 492 11 ME ME NNP cord-282610-zim7nond 492 12 / / SYM cord-282610-zim7nond 492 13 CFS CFS NNP cord-282610-zim7nond 492 14 research research NN cord-282610-zim7nond 492 15 community community NN cord-282610-zim7nond 492 16 . . . cord-282610-zim7nond 493 1 However however RB cord-282610-zim7nond 493 2 , , , cord-282610-zim7nond 493 3 most most JJS cord-282610-zim7nond 493 4 immunostimulative immunostimulative JJ cord-282610-zim7nond 493 5 treatments treatment NNS cord-282610-zim7nond 493 6 that that WDT cord-282610-zim7nond 493 7 target target NN cord-282610-zim7nond 493 8 pathogens pathogen NNS cord-282610-zim7nond 493 9 are be VBP cord-282610-zim7nond 493 10 characterized characterize VBN cord-282610-zim7nond 493 11 by by IN cord-282610-zim7nond 493 12 immunopathology immunopathology NN cord-282610-zim7nond 493 13 - - : cord-282610-zim7nond 493 14 a a DT cord-282610-zim7nond 493 15 cascade cascade NN cord-282610-zim7nond 493 16 of of IN cord-282610-zim7nond 493 17 reactions reaction NNS cord-282610-zim7nond 493 18 in in IN cord-282610-zim7nond 493 19 which which WDT cord-282610-zim7nond 493 20 inflammation inflammation NN cord-282610-zim7nond 493 21 , , , cord-282610-zim7nond 493 22 cytokine cytokine NN cord-282610-zim7nond 493 23 release release NN cord-282610-zim7nond 493 24 and and CC cord-282610-zim7nond 493 25 endotoxin endotoxin NN cord-282610-zim7nond 493 26 release release NN cord-282610-zim7nond 493 27 are be VBP cord-282610-zim7nond 493 28 generated generate VBN cord-282610-zim7nond 493 29 as as IN cord-282610-zim7nond 493 30 part part NN cord-282610-zim7nond 493 31 of of IN cord-282610-zim7nond 493 32 the the DT cord-282610-zim7nond 493 33 immune immune JJ cord-282610-zim7nond 493 34 system system NN cord-282610-zim7nond 493 35 's 's POS cord-282610-zim7nond 493 36 response response NN cord-282610-zim7nond 493 37 to to IN cord-282610-zim7nond 493 38 microbial microbial JJ cord-282610-zim7nond 493 39 death death NN cord-282610-zim7nond 493 40 ( ( -LRB- cord-282610-zim7nond 493 41 192 192 CD cord-282610-zim7nond 493 42 ) ) -RRB- cord-282610-zim7nond 493 43 ( ( -LRB- cord-282610-zim7nond 493 44 193 193 CD cord-282610-zim7nond 493 45 ) ) -RRB- cord-282610-zim7nond 493 46 ( ( -LRB- cord-282610-zim7nond 493 47 194 194 CD cord-282610-zim7nond 493 48 ) ) -RRB- cord-282610-zim7nond 493 49 . . . cord-282610-zim7nond 494 1 The the DT cord-282610-zim7nond 494 2 death death NN cord-282610-zim7nond 494 3 of of IN cord-282610-zim7nond 494 4 intracellular intracellular JJ cord-282610-zim7nond 494 5 pathogens pathogen NNS cord-282610-zim7nond 494 6 is be VBZ cord-282610-zim7nond 494 7 particularly particularly RB cord-282610-zim7nond 494 8 difficult difficult JJ cord-282610-zim7nond 494 9 for for IN cord-282610-zim7nond 494 10 the the DT cord-282610-zim7nond 494 11 host host NN cord-282610-zim7nond 494 12 to to TO cord-282610-zim7nond 494 13 manage manage VB cord-282610-zim7nond 494 14 , , , cord-282610-zim7nond 494 15 as as IN cord-282610-zim7nond 494 16 the the DT cord-282610-zim7nond 494 17 body body NN cord-282610-zim7nond 494 18 must must MD cord-282610-zim7nond 494 19 deal deal VB cord-282610-zim7nond 494 20 with with IN cord-282610-zim7nond 494 21 debris debris NN cord-282610-zim7nond 494 22 generated generate VBN cord-282610-zim7nond 494 23 from from IN cord-282610-zim7nond 494 24 apoptosis apoptosis NN cord-282610-zim7nond 494 25 . . . cord-282610-zim7nond 495 1 Inflammation inflammation NN cord-282610-zim7nond 495 2 is be VBZ cord-282610-zim7nond 495 3 also also RB cord-282610-zim7nond 495 4 generated generate VBN cord-282610-zim7nond 495 5 in in IN cord-282610-zim7nond 495 6 response response NN cord-282610-zim7nond 495 7 to to IN cord-282610-zim7nond 495 8 bacterial bacterial JJ cord-282610-zim7nond 495 9 cell cell NN cord-282610-zim7nond 495 10 wall wall NN cord-282610-zim7nond 495 11 components component NNS cord-282610-zim7nond 495 12 including include VBG cord-282610-zim7nond 495 13 the the DT cord-282610-zim7nond 495 14 endotoxin endotoxin NN cord-282610-zim7nond 495 15 lipopolysaccharide lipopolysaccharide NN cord-282610-zim7nond 495 16 of of IN cord-282610-zim7nond 495 17 Gram gram NN cord-282610-zim7nond 495 18 - - HYPH cord-282610-zim7nond 495 19 negative negative JJ cord-282610-zim7nond 495 20 strains strain NNS cord-282610-zim7nond 495 21 ( ( -LRB- cord-282610-zim7nond 495 22 192 192 CD cord-282610-zim7nond 495 23 ) ) -RRB- cord-282610-zim7nond 495 24 . . . cord-282610-zim7nond 496 1 Luckily luckily RB cord-282610-zim7nond 496 2 , , , cord-282610-zim7nond 496 3 immunopathology immunopathology NN cord-282610-zim7nond 496 4 - - HYPH cord-282610-zim7nond 496 5 generated generate VBN cord-282610-zim7nond 496 6 symptoms symptom NNS cord-282610-zim7nond 496 7 are be VBP cord-282610-zim7nond 496 8 generally generally RB cord-282610-zim7nond 496 9 temporary temporary JJ cord-282610-zim7nond 496 10 in in IN cord-282610-zim7nond 496 11 nature nature NN cord-282610-zim7nond 496 12 , , , cord-282610-zim7nond 496 13 and and CC cord-282610-zim7nond 496 14 tend tend VBP cord-282610-zim7nond 496 15 to to TO cord-282610-zim7nond 496 16 subside subside VB cord-282610-zim7nond 496 17 as as IN cord-282610-zim7nond 496 18 an an DT cord-282610-zim7nond 496 19 increasing increase VBG cord-282610-zim7nond 496 20 number number NN cord-282610-zim7nond 496 21 of of IN cord-282610-zim7nond 496 22 pathogens pathogen NNS cord-282610-zim7nond 496 23 are be VBP cord-282610-zim7nond 496 24 eradicated eradicate VBN cord-282610-zim7nond 496 25 . . . cord-282610-zim7nond 497 1 Temporary temporary JJ cord-282610-zim7nond 497 2 immunopathology immunopathology NN cord-282610-zim7nond 497 3 resulting result VBG cord-282610-zim7nond 497 4 from from IN cord-282610-zim7nond 497 5 antimicrobial antimicrobial JJ cord-282610-zim7nond 497 6 treatment treatment NN cord-282610-zim7nond 497 7 has have VBZ cord-282610-zim7nond 497 8 been be VBN cord-282610-zim7nond 497 9 documented document VBN cord-282610-zim7nond 497 10 for for IN cord-282610-zim7nond 497 11 over over IN cord-282610-zim7nond 497 12 a a DT cord-282610-zim7nond 497 13 century century NN cord-282610-zim7nond 497 14 , , , cord-282610-zim7nond 497 15 with with IN cord-282610-zim7nond 497 16 symptoms symptom NNS cord-282610-zim7nond 497 17 varying vary VBG cord-282610-zim7nond 497 18 depending depend VBG cord-282610-zim7nond 497 19 on on IN cord-282610-zim7nond 497 20 the the DT cord-282610-zim7nond 497 21 nature nature NN cord-282610-zim7nond 497 22 of of IN cord-282610-zim7nond 497 23 targeted target VBN cord-282610-zim7nond 497 24 pathogens pathogen NNS cord-282610-zim7nond 497 25 . . . cord-282610-zim7nond 498 1 First first RB cord-282610-zim7nond 498 2 referred refer VBD cord-282610-zim7nond 498 3 to to IN cord-282610-zim7nond 498 4 as as IN cord-282610-zim7nond 498 5 the the DT cord-282610-zim7nond 498 6 Jarisch Jarisch NNP cord-282610-zim7nond 498 7 - - HYPH cord-282610-zim7nond 498 8 Herxheimer Herxheimer NNP cord-282610-zim7nond 498 9 reaction reaction NN cord-282610-zim7nond 498 10 , , , cord-282610-zim7nond 498 11 the the DT cord-282610-zim7nond 498 12 phenomenon phenomenon NN cord-282610-zim7nond 498 13 was be VBD cord-282610-zim7nond 498 14 originally originally RB cord-282610-zim7nond 498 15 observed observe VBN cord-282610-zim7nond 498 16 during during IN cord-282610-zim7nond 498 17 treatment treatment NN cord-282610-zim7nond 498 18 of of IN cord-282610-zim7nond 498 19 syphilis syphili NNS cord-282610-zim7nond 498 20 with with IN cord-282610-zim7nond 498 21 mercury mercury NN cord-282610-zim7nond 498 22 and and CC cord-282610-zim7nond 498 23 penicillin penicillin NNP cord-282610-zim7nond 498 24 ( ( -LRB- cord-282610-zim7nond 498 25 195 195 CD cord-282610-zim7nond 498 26 , , , cord-282610-zim7nond 498 27 196 196 CD cord-282610-zim7nond 498 28 ) ) -RRB- cord-282610-zim7nond 498 29 . . . cord-282610-zim7nond 499 1 The the DT cord-282610-zim7nond 499 2 Jarisch Jarisch NNP cord-282610-zim7nond 499 3 - - HYPH cord-282610-zim7nond 499 4 Herxheimer Herxheimer NNP cord-282610-zim7nond 499 5 reaction reaction NN cord-282610-zim7nond 499 6 / / SYM cord-282610-zim7nond 499 7 immunopathology immunopathology NN cord-282610-zim7nond 499 8 has have VBZ cord-282610-zim7nond 499 9 since since IN cord-282610-zim7nond 499 10 been be VBN cord-282610-zim7nond 499 11 noted note VBN cord-282610-zim7nond 499 12 in in IN cord-282610-zim7nond 499 13 a a DT cord-282610-zim7nond 499 14 broad broad JJ cord-282610-zim7nond 499 15 spectrum spectrum NN cord-282610-zim7nond 499 16 of of IN cord-282610-zim7nond 499 17 chronic chronic JJ cord-282610-zim7nond 499 18 inflammatory inflammatory JJ cord-282610-zim7nond 499 19 conditions condition NNS cord-282610-zim7nond 499 20 including include VBG cord-282610-zim7nond 499 21 tuberculosis tuberculosis NN cord-282610-zim7nond 499 22 and and CC cord-282610-zim7nond 499 23 Brucellosis brucellosis NN cord-282610-zim7nond 499 24 ( ( -LRB- cord-282610-zim7nond 499 25 197 197 CD cord-282610-zim7nond 499 26 ) ) -RRB- cord-282610-zim7nond 499 27 . . . cord-282610-zim7nond 500 1 Short short JJ cord-282610-zim7nond 500 2 - - HYPH cord-282610-zim7nond 500 3 term term NN cord-282610-zim7nond 500 4 immunopathology immunopathology NN cord-282610-zim7nond 500 5 is be VBZ cord-282610-zim7nond 500 6 also also RB cord-282610-zim7nond 500 7 a a DT cord-282610-zim7nond 500 8 central central JJ cord-282610-zim7nond 500 9 feature feature NN cord-282610-zim7nond 500 10 of of IN cord-282610-zim7nond 500 11 acute acute JJ cord-282610-zim7nond 500 12 infection infection NN cord-282610-zim7nond 500 13 . . . cord-282610-zim7nond 501 1 If if IN cord-282610-zim7nond 501 2 a a DT cord-282610-zim7nond 501 3 patient patient NN cord-282610-zim7nond 501 4 develops develop VBZ cord-282610-zim7nond 501 5 the the DT cord-282610-zim7nond 501 6 flu flu NN cord-282610-zim7nond 501 7 , , , cord-282610-zim7nond 501 8 inflammatory inflammatory JJ cord-282610-zim7nond 501 9 symptoms symptom NNS cord-282610-zim7nond 501 10 increase increase VBP cord-282610-zim7nond 501 11 as as IN cord-282610-zim7nond 501 12 the the DT cord-282610-zim7nond 501 13 immune immune JJ cord-282610-zim7nond 501 14 system system NN cord-282610-zim7nond 501 15 releases release VBZ cord-282610-zim7nond 501 16 cytokines cytokine NNS cord-282610-zim7nond 501 17 and and CC cord-282610-zim7nond 501 18 chemokines chemokine NNS cord-282610-zim7nond 501 19 in in IN cord-282610-zim7nond 501 20 response response NN cord-282610-zim7nond 501 21 to to IN cord-282610-zim7nond 501 22 the the DT cord-282610-zim7nond 501 23 infecting infect VBG cord-282610-zim7nond 501 24 virus virus NN cord-282610-zim7nond 501 25 . . . cord-282610-zim7nond 502 1 HIV HIV NNP cord-282610-zim7nond 502 2 / / SYM cord-282610-zim7nond 502 3 AIDS AIDS NNP cord-282610-zim7nond 502 4 patients patient NNS cord-282610-zim7nond 502 5 undergo undergo VBP cord-282610-zim7nond 502 6 a a DT cord-282610-zim7nond 502 7 form form NN cord-282610-zim7nond 502 8 of of IN cord-282610-zim7nond 502 9 immunopathology immunopathology NN cord-282610-zim7nond 502 10 called call VBN cord-282610-zim7nond 502 11 Immune Immune NNP cord-282610-zim7nond 502 12 Reconstitution Reconstitution NNP cord-282610-zim7nond 502 13 Inflammatory Inflammatory NNP cord-282610-zim7nond 502 14 Syndrome Syndrome NNP cord-282610-zim7nond 502 15 ( ( -LRB- cord-282610-zim7nond 502 16 IRIS IRIS NNP cord-282610-zim7nond 502 17 ) ) -RRB- cord-282610-zim7nond 502 18 following follow VBG cord-282610-zim7nond 502 19 treatment treatment NN cord-282610-zim7nond 502 20 with with IN cord-282610-zim7nond 502 21 Combination Combination NNP cord-282610-zim7nond 502 22 Antiretroviral Antiretroviral NNP cord-282610-zim7nond 502 23 Therapy Therapy NNP cord-282610-zim7nond 502 24 ( ( -LRB- cord-282610-zim7nond 502 25 ART art NN cord-282610-zim7nond 502 26 ) ) -RRB- cord-282610-zim7nond 502 27 ( ( -LRB- cord-282610-zim7nond 502 28 198 198 CD cord-282610-zim7nond 502 29 ) ) -RRB- cord-282610-zim7nond 502 30 . . . cord-282610-zim7nond 503 1 IRIS IRIS NNP cord-282610-zim7nond 503 2 occurs occur VBZ cord-282610-zim7nond 503 3 as as IN cord-282610-zim7nond 503 4 ART art NN cord-282610-zim7nond 503 5 enables enable VBZ cord-282610-zim7nond 503 6 the the DT cord-282610-zim7nond 503 7 host host NN cord-282610-zim7nond 503 8 immune immune JJ cord-282610-zim7nond 503 9 system system NN cord-282610-zim7nond 503 10 to to TO cord-282610-zim7nond 503 11 better well JJR cord-282610-zim7nond 503 12 target target NN cord-282610-zim7nond 503 13 pathogens pathogen NNS cord-282610-zim7nond 503 14 acquired acquire VBN cord-282610-zim7nond 503 15 during during IN cord-282610-zim7nond 503 16 previous previous JJ cord-282610-zim7nond 503 17 periods period NNS cord-282610-zim7nond 503 18 of of IN cord-282610-zim7nond 503 19 HIV HIV NNP cord-282610-zim7nond 503 20 - - HYPH cord-282610-zim7nond 503 21 driven drive VBN cord-282610-zim7nond 503 22 immunosuppression immunosuppression NN cord-282610-zim7nond 503 23 . . . cord-282610-zim7nond 504 1 A a DT cord-282610-zim7nond 504 2 range range NN cord-282610-zim7nond 504 3 of of IN cord-282610-zim7nond 504 4 well well RB cord-282610-zim7nond 504 5 - - HYPH cord-282610-zim7nond 504 6 characterized characterize VBN cord-282610-zim7nond 504 7 pathogens pathogen NNS cord-282610-zim7nond 504 8 have have VBP cord-282610-zim7nond 504 9 been be VBN cord-282610-zim7nond 504 10 linked link VBN cord-282610-zim7nond 504 11 to to IN cord-282610-zim7nond 504 12 IRIS IRIS NNP cord-282610-zim7nond 504 13 including include VBG cord-282610-zim7nond 504 14 the the DT cord-282610-zim7nond 504 15 herpesviruses herpesviruse NNS cord-282610-zim7nond 504 16 and and CC cord-282610-zim7nond 504 17 M. M. NNP cord-282610-zim7nond 504 18 tuberculosis tuberculosis NN cord-282610-zim7nond 504 19 ( ( -LRB- cord-282610-zim7nond 504 20 193 193 CD cord-282610-zim7nond 504 21 ) ) -RRB- cord-282610-zim7nond 504 22 . . . cord-282610-zim7nond 505 1 However however RB cord-282610-zim7nond 505 2 , , , cord-282610-zim7nond 505 3 the the DT cord-282610-zim7nond 505 4 inflammatory inflammatory JJ cord-282610-zim7nond 505 5 reaction reaction NN cord-282610-zim7nond 505 6 is be VBZ cord-282610-zim7nond 505 7 also also RB cord-282610-zim7nond 505 8 noted note VBN cord-282610-zim7nond 505 9 in in IN cord-282610-zim7nond 505 10 culture culture NN cord-282610-zim7nond 505 11 - - HYPH cord-282610-zim7nond 505 12 negative negative JJ cord-282610-zim7nond 505 13 patients patient NNS cord-282610-zim7nond 505 14 , , , cord-282610-zim7nond 505 15 suggesting suggest VBG cord-282610-zim7nond 505 16 IRIS IRIS NNP cord-282610-zim7nond 505 17 may may MD cord-282610-zim7nond 505 18 also also RB cord-282610-zim7nond 505 19 involve involve VB cord-282610-zim7nond 505 20 novel novel JJ cord-282610-zim7nond 505 21 or or CC cord-282610-zim7nond 505 22 uncharacterized uncharacterized JJ cord-282610-zim7nond 505 23 pathogens pathogen NNS cord-282610-zim7nond 505 24 ( ( -LRB- cord-282610-zim7nond 505 25 198 198 CD cord-282610-zim7nond 505 26 ) ) -RRB- cord-282610-zim7nond 505 27 . . . cord-282610-zim7nond 506 1 Over over IN cord-282610-zim7nond 506 2 the the DT cord-282610-zim7nond 506 3 past past JJ cord-282610-zim7nond 506 4 decade decade NN cord-282610-zim7nond 506 5 , , , cord-282610-zim7nond 506 6 in in IN cord-282610-zim7nond 506 7 concert concert NN cord-282610-zim7nond 506 8 with with IN cord-282610-zim7nond 506 9 our -PRON- PRP$ cord-282610-zim7nond 506 10 clinical clinical JJ cord-282610-zim7nond 506 11 collaborators collaborator NNS cord-282610-zim7nond 506 12 , , , cord-282610-zim7nond 506 13 we -PRON- PRP cord-282610-zim7nond 506 14 developed develop VBD cord-282610-zim7nond 506 15 an an DT cord-282610-zim7nond 506 16 immunostimulative immunostimulative JJ cord-282610-zim7nond 506 17 therapy therapy NN cord-282610-zim7nond 506 18 used use VBN cord-282610-zim7nond 506 19 to to TO cord-282610-zim7nond 506 20 treat treat VB cord-282610-zim7nond 506 21 patients patient NNS cord-282610-zim7nond 506 22 with with IN cord-282610-zim7nond 506 23 a a DT cord-282610-zim7nond 506 24 range range NN cord-282610-zim7nond 506 25 of of IN cord-282610-zim7nond 506 26 chronic chronic JJ cord-282610-zim7nond 506 27 inflammatory inflammatory JJ cord-282610-zim7nond 506 28 conditions condition NNS cord-282610-zim7nond 506 29 ( ( -LRB- cord-282610-zim7nond 506 30 200 200 CD cord-282610-zim7nond 506 31 ) ) -RRB- cord-282610-zim7nond 506 32 . . . cord-282610-zim7nond 507 1 Treatment treatment NN cord-282610-zim7nond 507 2 centers center NNS cord-282610-zim7nond 507 3 on on IN cord-282610-zim7nond 507 4 the the DT cord-282610-zim7nond 507 5 use use NN cord-282610-zim7nond 507 6 of of IN cord-282610-zim7nond 507 7 a a DT cord-282610-zim7nond 507 8 putative putative JJ cord-282610-zim7nond 507 9 VDR VDR NNP cord-282610-zim7nond 507 10 agonist agonist NN cord-282610-zim7nond 507 11 in in IN cord-282610-zim7nond 507 12 the the DT cord-282610-zim7nond 507 13 form form NN cord-282610-zim7nond 507 14 of of IN cord-282610-zim7nond 507 15 olmesartan olmesartan NNP cord-282610-zim7nond 507 16 medoxomil medoxomil NNP cord-282610-zim7nond 507 17 , , , cord-282610-zim7nond 507 18 with with IN cord-282610-zim7nond 507 19 the the DT cord-282610-zim7nond 507 20 goal goal NN cord-282610-zim7nond 507 21 of of IN cord-282610-zim7nond 507 22 reactivating reactivate VBG cord-282610-zim7nond 507 23 components component NNS cord-282610-zim7nond 507 24 of of IN cord-282610-zim7nond 507 25 innate innate JJ cord-282610-zim7nond 507 26 immunity immunity NN cord-282610-zim7nond 507 27 under under IN cord-282610-zim7nond 507 28 VDR VDR NNP cord-282610-zim7nond 507 29 control control NN cord-282610-zim7nond 507 30 . . . cord-282610-zim7nond 508 1 In in IN cord-282610-zim7nond 508 2 2013 2013 CD cord-282610-zim7nond 508 3 , , , cord-282610-zim7nond 508 4 we -PRON- PRP cord-282610-zim7nond 508 5 published publish VBD cord-282610-zim7nond 508 6 a a DT cord-282610-zim7nond 508 7 series series NN cord-282610-zim7nond 508 8 of of IN cord-282610-zim7nond 508 9 case case NN cord-282610-zim7nond 508 10 histories history NNS cord-282610-zim7nond 508 11 demonstrating demonstrate VBG cord-282610-zim7nond 508 12 improvement improvement NN cord-282610-zim7nond 508 13 in in IN cord-282610-zim7nond 508 14 ME ME NNP cord-282610-zim7nond 508 15 / / SYM cord-282610-zim7nond 508 16 CFS CFS NNP cord-282610-zim7nond 508 17 patients patient NNS cord-282610-zim7nond 508 18 administered administer VBD cord-282610-zim7nond 508 19 this this DT cord-282610-zim7nond 508 20 treatment treatment NN cord-282610-zim7nond 508 21 ( ( -LRB- cord-282610-zim7nond 508 22 199 199 CD cord-282610-zim7nond 508 23 ) ) -RRB- cord-282610-zim7nond 508 24 . . . cord-282610-zim7nond 509 1 However however RB cord-282610-zim7nond 509 2 , , , cord-282610-zim7nond 509 3 all all DT cord-282610-zim7nond 509 4 ME ME NNP cord-282610-zim7nond 509 5 / / SYM cord-282610-zim7nond 509 6 CFS CFS NNP cord-282610-zim7nond 509 7 subjects subject NNS cord-282610-zim7nond 509 8 administered administer VBD cord-282610-zim7nond 509 9 the the DT cord-282610-zim7nond 509 10 therapy therapy NN cord-282610-zim7nond 509 11 experienced experience VBD cord-282610-zim7nond 509 12 immunopathology immunopathology NN cord-282610-zim7nond 509 13 and and CC cord-282610-zim7nond 509 14 associated associate VBD cord-282610-zim7nond 509 15 inflammatory inflammatory JJ cord-282610-zim7nond 509 16 symptom symptom NN cord-282610-zim7nond 509 17 increases increase NNS cord-282610-zim7nond 509 18 that that WDT cord-282610-zim7nond 509 19 lasted last VBD cord-282610-zim7nond 509 20 for for IN cord-282610-zim7nond 509 21 many many JJ cord-282610-zim7nond 509 22 years year NNS cord-282610-zim7nond 509 23 . . . cord-282610-zim7nond 510 1 As as IN cord-282610-zim7nond 510 2 a a DT cord-282610-zim7nond 510 3 general general JJ cord-282610-zim7nond 510 4 trend trend NN cord-282610-zim7nond 510 5 , , , cord-282610-zim7nond 510 6 patients patient NNS cord-282610-zim7nond 510 7 administered administer VBD cord-282610-zim7nond 510 8 the the DT cord-282610-zim7nond 510 9 treatment treatment NN cord-282610-zim7nond 510 10 during during IN cord-282610-zim7nond 510 11 earlier early JJR cord-282610-zim7nond 510 12 stages stage NNS cord-282610-zim7nond 510 13 of of IN cord-282610-zim7nond 510 14 disease disease NN cord-282610-zim7nond 510 15 experienced experience VBD cord-282610-zim7nond 510 16 less less JJR cord-282610-zim7nond 510 17 immunopathology immunopathology NN cord-282610-zim7nond 510 18 , , , cord-282610-zim7nond 510 19 emphasizing emphasize VBG cord-282610-zim7nond 510 20 the the DT cord-282610-zim7nond 510 21 need need NN cord-282610-zim7nond 510 22 for for IN cord-282610-zim7nond 510 23 immunostimulative immunostimulative JJ cord-282610-zim7nond 510 24 therapies therapy NNS cord-282610-zim7nond 510 25 to to TO cord-282610-zim7nond 510 26 be be VB cord-282610-zim7nond 510 27 used use VBN cord-282610-zim7nond 510 28 in in IN cord-282610-zim7nond 510 29 a a DT cord-282610-zim7nond 510 30 predictive predictive JJ cord-282610-zim7nond 510 31 and and CC cord-282610-zim7nond 510 32 even even RB cord-282610-zim7nond 510 33 preventative preventative JJ cord-282610-zim7nond 510 34 fashion fashion NN cord-282610-zim7nond 510 35 . . . cord-282610-zim7nond 511 1 While while IN cord-282610-zim7nond 511 2 some some DT cord-282610-zim7nond 511 3 ME ME NNP cord-282610-zim7nond 511 4 / / SYM cord-282610-zim7nond 511 5 CFS CFS NNP cord-282610-zim7nond 511 6 physicians physician NNS cord-282610-zim7nond 511 7 may may MD cord-282610-zim7nond 511 8 feel feel VB cord-282610-zim7nond 511 9 uneasy uneasy JJ cord-282610-zim7nond 511 10 about about IN cord-282610-zim7nond 511 11 the the DT cord-282610-zim7nond 511 12 suffering suffering NN cord-282610-zim7nond 511 13 induced induce VBN cord-282610-zim7nond 511 14 by by IN cord-282610-zim7nond 511 15 immunopathology immunopathology NN cord-282610-zim7nond 511 16 , , , cord-282610-zim7nond 511 17 other other JJ cord-282610-zim7nond 511 18 research research NN cord-282610-zim7nond 511 19 communities community NNS cord-282610-zim7nond 511 20 have have VBP cord-282610-zim7nond 511 21 become become VBN cord-282610-zim7nond 511 22 accustomed accustomed JJ cord-282610-zim7nond 511 23 to to IN cord-282610-zim7nond 511 24 treatments treatment NNS cord-282610-zim7nond 511 25 that that WDT cord-282610-zim7nond 511 26 cause cause VBP cord-282610-zim7nond 511 27 temporary temporary JJ cord-282610-zim7nond 511 28 discomfort discomfort NN cord-282610-zim7nond 511 29 . . . cord-282610-zim7nond 512 1 Novel novel JJ cord-282610-zim7nond 512 2 cancer cancer NN cord-282610-zim7nond 512 3 immunotherapies immunotherapy NNS cord-282610-zim7nond 512 4 also also RB cord-282610-zim7nond 512 5 generate generate VBP cord-282610-zim7nond 512 6 immunopathology immunopathology NN cord-282610-zim7nond 512 7 by by IN cord-282610-zim7nond 512 8 activating activate VBG cord-282610-zim7nond 512 9 patient patient JJ cord-282610-zim7nond 512 10 T t NN cord-282610-zim7nond 512 11 cells cell NNS cord-282610-zim7nond 512 12 . . . cord-282610-zim7nond 513 1 This this DT cord-282610-zim7nond 513 2 allows allow VBZ cord-282610-zim7nond 513 3 the the DT cord-282610-zim7nond 513 4 immune immune JJ cord-282610-zim7nond 513 5 system system NN cord-282610-zim7nond 513 6 to to TO cord-282610-zim7nond 513 7 better well RBR cord-282610-zim7nond 513 8 target target VB cord-282610-zim7nond 513 9 malignant malignant JJ cord-282610-zim7nond 513 10 tumors tumor NNS cord-282610-zim7nond 513 11 ( ( -LRB- cord-282610-zim7nond 513 12 194 194 CD cord-282610-zim7nond 513 13 , , , cord-282610-zim7nond 513 14 201 201 CD cord-282610-zim7nond 513 15 ) ) -RRB- cord-282610-zim7nond 513 16 . . . cord-282610-zim7nond 514 1 The the DT cord-282610-zim7nond 514 2 resulting result VBG cord-282610-zim7nond 514 3 " " `` cord-282610-zim7nond 514 4 cytokine cytokine NN cord-282610-zim7nond 514 5 release release NN cord-282610-zim7nond 514 6 syndrome syndrome NN cord-282610-zim7nond 514 7 " " `` cord-282610-zim7nond 514 8 leads lead VBZ cord-282610-zim7nond 514 9 to to IN cord-282610-zim7nond 514 10 profound profound JJ cord-282610-zim7nond 514 11 , , , cord-282610-zim7nond 514 12 temporary temporary JJ cord-282610-zim7nond 514 13 , , , cord-282610-zim7nond 514 14 symptom symptom NN cord-282610-zim7nond 514 15 increases increase NNS cord-282610-zim7nond 514 16 . . . cord-282610-zim7nond 515 1 However however RB cord-282610-zim7nond 515 2 , , , cord-282610-zim7nond 515 3 these these DT cord-282610-zim7nond 515 4 increased increase VBN cord-282610-zim7nond 515 5 symptoms symptom NNS cord-282610-zim7nond 515 6 are be VBP cord-282610-zim7nond 515 7 considered consider VBN cord-282610-zim7nond 515 8 acceptable acceptable JJ cord-282610-zim7nond 515 9 , , , cord-282610-zim7nond 515 10 as as IN cord-282610-zim7nond 515 11 patients patient NNS cord-282610-zim7nond 515 12 who who WP cord-282610-zim7nond 515 13 endure endure VBP cord-282610-zim7nond 515 14 the the DT cord-282610-zim7nond 515 15 reaction reaction NN cord-282610-zim7nond 515 16 are be VBP cord-282610-zim7nond 515 17 more more RBR cord-282610-zim7nond 515 18 likely likely JJ cord-282610-zim7nond 515 19 to to TO cord-282610-zim7nond 515 20 enter enter VB cord-282610-zim7nond 515 21 a a DT cord-282610-zim7nond 515 22 state state NN cord-282610-zim7nond 515 23 of of IN cord-282610-zim7nond 515 24 remission remission NN cord-282610-zim7nond 515 25 . . . cord-282610-zim7nond 516 1 Since since IN cord-282610-zim7nond 516 2 many many JJ cord-282610-zim7nond 516 3 forms form NNS cord-282610-zim7nond 516 4 of of IN cord-282610-zim7nond 516 5 cancer cancer NN cord-282610-zim7nond 516 6 are be VBP cord-282610-zim7nond 516 7 tied tie VBN cord-282610-zim7nond 516 8 to to IN cord-282610-zim7nond 516 9 severe severe JJ cord-282610-zim7nond 516 10 microbiome microbiome NN cord-282610-zim7nond 516 11 dysbiosis dysbiosis NN cord-282610-zim7nond 516 12 , , , cord-282610-zim7nond 516 13 at at IN cord-282610-zim7nond 516 14 least least JJS cord-282610-zim7nond 516 15 part part NN cord-282610-zim7nond 516 16 of of IN cord-282610-zim7nond 516 17 the the DT cord-282610-zim7nond 516 18 " " `` cord-282610-zim7nond 516 19 cytokine cytokine NN cord-282610-zim7nond 516 20 release release NN cord-282610-zim7nond 516 21 syndrome syndrome NN cord-282610-zim7nond 516 22 " " '' cord-282610-zim7nond 516 23 may may MD cord-282610-zim7nond 516 24 result result VB cord-282610-zim7nond 516 25 from from IN cord-282610-zim7nond 516 26 the the DT cord-282610-zim7nond 516 27 death death NN cord-282610-zim7nond 516 28 of of IN cord-282610-zim7nond 516 29 persistent persistent JJ cord-282610-zim7nond 516 30 pathogens pathogen NNS cord-282610-zim7nond 516 31 . . . cord-282610-zim7nond 517 1 The the DT cord-282610-zim7nond 517 2 history history NN cord-282610-zim7nond 517 3 of of IN cord-282610-zim7nond 517 4 ME ME NNP cord-282610-zim7nond 517 5 / / SYM cord-282610-zim7nond 517 6 CFS CFS NNP cord-282610-zim7nond 517 7 strongly strongly RB cord-282610-zim7nond 517 8 suggests suggest VBZ cord-282610-zim7nond 517 9 that that IN cord-282610-zim7nond 517 10 infectious infectious JJ cord-282610-zim7nond 517 11 agents agent NNS cord-282610-zim7nond 517 12 play play VBP cord-282610-zim7nond 517 13 a a DT cord-282610-zim7nond 517 14 central central JJ cord-282610-zim7nond 517 15 role role NN cord-282610-zim7nond 517 16 in in IN cord-282610-zim7nond 517 17 driving drive VBG cord-282610-zim7nond 517 18 the the DT cord-282610-zim7nond 517 19 disease disease NN cord-282610-zim7nond 517 20 process process NN cord-282610-zim7nond 517 21 . . . cord-282610-zim7nond 518 1 However however RB cord-282610-zim7nond 518 2 , , , cord-282610-zim7nond 518 3 the the DT cord-282610-zim7nond 518 4 discovery discovery NN cord-282610-zim7nond 518 5 of of IN cord-282610-zim7nond 518 6 the the DT cord-282610-zim7nond 518 7 human human JJ cord-282610-zim7nond 518 8 microbiome microbiome NN cord-282610-zim7nond 518 9 has have VBZ cord-282610-zim7nond 518 10 revolutionized revolutionize VBN cord-282610-zim7nond 518 11 the the DT cord-282610-zim7nond 518 12 manner manner NN cord-282610-zim7nond 518 13 in in IN cord-282610-zim7nond 518 14 which which WDT cord-282610-zim7nond 518 15 persistent persistent JJ cord-282610-zim7nond 518 16 infection infection NN cord-282610-zim7nond 518 17 and and CC cord-282610-zim7nond 518 18 chronic chronic JJ cord-282610-zim7nond 518 19 inflammation inflammation NN cord-282610-zim7nond 518 20 are be VBP cord-282610-zim7nond 518 21 understood understand VBN cord-282610-zim7nond 518 22 and and CC cord-282610-zim7nond 518 23 studied study VBN cord-282610-zim7nond 518 24 . . . cord-282610-zim7nond 519 1 Humans human NNS cord-282610-zim7nond 519 2 harbor harbor VBP cord-282610-zim7nond 519 3 extensive extensive JJ cord-282610-zim7nond 519 4 microbiome microbiome NN cord-282610-zim7nond 519 5 communities community NNS cord-282610-zim7nond 519 6 of of IN cord-282610-zim7nond 519 7 bacteria bacteria NNS cord-282610-zim7nond 519 8 , , , cord-282610-zim7nond 519 9 viruses virus NNS cord-282610-zim7nond 519 10 , , , cord-282610-zim7nond 519 11 and and CC cord-282610-zim7nond 519 12 fungi fungus NNS cord-282610-zim7nond 519 13 in in IN cord-282610-zim7nond 519 14 nearly nearly RB cord-282610-zim7nond 519 15 all all DT cord-282610-zim7nond 519 16 tissue tissue NN cord-282610-zim7nond 519 17 and and CC cord-282610-zim7nond 519 18 blood blood NN cord-282610-zim7nond 519 19 . . . cord-282610-zim7nond 520 1 The the DT cord-282610-zim7nond 520 2 hundreds hundred NNS cord-282610-zim7nond 520 3 of of IN cord-282610-zim7nond 520 4 millions million NNS cord-282610-zim7nond 520 5 of of IN cord-282610-zim7nond 520 6 unique unique JJ cord-282610-zim7nond 520 7 genes gene NNS cord-282610-zim7nond 520 8 harbored harbor VBN cord-282610-zim7nond 520 9 by by IN cord-282610-zim7nond 520 10 this this DT cord-282610-zim7nond 520 11 microbiome microbiome NN cord-282610-zim7nond 520 12 dwarf dwarf NN cord-282610-zim7nond 520 13 the the DT cord-282610-zim7nond 520 14 ∼20,500 ∼20,500 CD cord-282610-zim7nond 520 15 in in IN cord-282610-zim7nond 520 16 the the DT cord-282610-zim7nond 520 17 human human JJ cord-282610-zim7nond 520 18 genome genome NN cord-282610-zim7nond 520 19 . . . cord-282610-zim7nond 521 1 Humans human NNS cord-282610-zim7nond 521 2 are be VBP cord-282610-zim7nond 521 3 best best RB cord-282610-zim7nond 521 4 described describe VBN cord-282610-zim7nond 521 5 as as IN cord-282610-zim7nond 521 6 holobionts holobiont NNS cord-282610-zim7nond 521 7 , , , cord-282610-zim7nond 521 8 in in IN cord-282610-zim7nond 521 9 which which WDT cord-282610-zim7nond 521 10 these these DT cord-282610-zim7nond 521 11 microbial microbial JJ cord-282610-zim7nond 521 12 genomes genome NNS cord-282610-zim7nond 521 13 and and CC cord-282610-zim7nond 521 14 the the DT cord-282610-zim7nond 521 15 human human JJ cord-282610-zim7nond 521 16 genome genome NN cord-282610-zim7nond 521 17 continually continually RB cord-282610-zim7nond 521 18 interact interact VBP cord-282610-zim7nond 521 19 to to TO cord-282610-zim7nond 521 20 regulate regulate VB cord-282610-zim7nond 521 21 host host NN cord-282610-zim7nond 521 22 gene gene NN cord-282610-zim7nond 521 23 expression expression NN cord-282610-zim7nond 521 24 , , , cord-282610-zim7nond 521 25 metabolism metabolism NN cord-282610-zim7nond 521 26 and and CC cord-282610-zim7nond 521 27 immunity immunity NN cord-282610-zim7nond 521 28 . . . cord-282610-zim7nond 522 1 Many many JJ cord-282610-zim7nond 522 2 inflammatory inflammatory JJ cord-282610-zim7nond 522 3 disease disease NN cord-282610-zim7nond 522 4 states state NNS cord-282610-zim7nond 522 5 , , , cord-282610-zim7nond 522 6 including include VBG cord-282610-zim7nond 522 7 neurological neurological JJ cord-282610-zim7nond 522 8 conditions condition NNS cord-282610-zim7nond 522 9 and and CC cord-282610-zim7nond 522 10 cancers cancer NNS cord-282610-zim7nond 522 11 , , , cord-282610-zim7nond 522 12 are be VBP cord-282610-zim7nond 522 13 tied tie VBN cord-282610-zim7nond 522 14 to to IN cord-282610-zim7nond 522 15 dysbiosis dysbiosis NN cord-282610-zim7nond 522 16 or or CC cord-282610-zim7nond 522 17 imbalance imbalance NN cord-282610-zim7nond 522 18 of of IN cord-282610-zim7nond 522 19 human human JJ cord-282610-zim7nond 522 20 microbiome microbiome NN cord-282610-zim7nond 522 21 communities community NNS cord-282610-zim7nond 522 22 in in IN cord-282610-zim7nond 522 23 various various JJ cord-282610-zim7nond 522 24 body body NN cord-282610-zim7nond 522 25 sites site NNS cord-282610-zim7nond 522 26 . . . cord-282610-zim7nond 523 1 While while IN cord-282610-zim7nond 523 2 gut gut NN cord-282610-zim7nond 523 3 microbiome microbiome NN cord-282610-zim7nond 523 4 dysbiosis dysbiosis NN cord-282610-zim7nond 523 5 has have VBZ cord-282610-zim7nond 523 6 already already RB cord-282610-zim7nond 523 7 been be VBN cord-282610-zim7nond 523 8 identified identify VBN cord-282610-zim7nond 523 9 in in IN cord-282610-zim7nond 523 10 ME ME NNP cord-282610-zim7nond 523 11 / / SYM cord-282610-zim7nond 523 12 CFS CFS NNP cord-282610-zim7nond 523 13 , , , cord-282610-zim7nond 523 14 distinct distinct JJ cord-282610-zim7nond 523 15 microbial microbial JJ cord-282610-zim7nond 523 16 and and CC cord-282610-zim7nond 523 17 viral viral JJ cord-282610-zim7nond 523 18 communities community NNS cord-282610-zim7nond 523 19 may may MD cord-282610-zim7nond 523 20 additionally additionally RB cord-282610-zim7nond 523 21 persist persist VB cord-282610-zim7nond 523 22 in in IN cord-282610-zim7nond 523 23 ME ME NNP cord-282610-zim7nond 523 24 / / SYM cord-282610-zim7nond 523 25 CFS CFS NNP cord-282610-zim7nond 523 26 blood blood NN cord-282610-zim7nond 523 27 and and CC cord-282610-zim7nond 523 28 brain brain NN cord-282610-zim7nond 523 29 tissue tissue NN cord-282610-zim7nond 523 30 . . . cord-282610-zim7nond 524 1 Possible possible JJ cord-282610-zim7nond 524 2 identification identification NN cord-282610-zim7nond 524 3 of of IN cord-282610-zim7nond 524 4 these these DT cord-282610-zim7nond 524 5 microbiomes microbiome NNS cord-282610-zim7nond 524 6 should should MD cord-282610-zim7nond 524 7 be be VB cord-282610-zim7nond 524 8 a a DT cord-282610-zim7nond 524 9 priority priority NN cord-282610-zim7nond 524 10 for for IN cord-282610-zim7nond 524 11 the the DT cord-282610-zim7nond 524 12 ME ME NNP cord-282610-zim7nond 524 13 / / SYM cord-282610-zim7nond 524 14 CFS CFS NNP cord-282610-zim7nond 524 15 research research NN cord-282610-zim7nond 524 16 community community NN cord-282610-zim7nond 524 17 , , , cord-282610-zim7nond 524 18 but but CC cord-282610-zim7nond 524 19 analysis analysis NN cord-282610-zim7nond 524 20 requires require VBZ cord-282610-zim7nond 524 21 the the DT cord-282610-zim7nond 524 22 use use NN cord-282610-zim7nond 524 23 of of IN cord-282610-zim7nond 524 24 very very RB cord-282610-zim7nond 524 25 specific specific JJ cord-282610-zim7nond 524 26 technologies technology NNS cord-282610-zim7nond 524 27 and and CC cord-282610-zim7nond 524 28 methodologies methodology NNS cord-282610-zim7nond 524 29 . . . cord-282610-zim7nond 525 1 Pathogens pathogen NNS cord-282610-zim7nond 525 2 and and CC cord-282610-zim7nond 525 3 their -PRON- PRP$ cord-282610-zim7nond 525 4 associated associate VBN cord-282610-zim7nond 525 5 proteins protein NNS cord-282610-zim7nond 525 6 / / SYM cord-282610-zim7nond 525 7 metabolites metabolite NNS cord-282610-zim7nond 525 8 control control VBP cord-282610-zim7nond 525 9 human human JJ cord-282610-zim7nond 525 10 metabolism metabolism NN cord-282610-zim7nond 525 11 and and CC cord-282610-zim7nond 525 12 gene gene NN cord-282610-zim7nond 525 13 expression expression NN cord-282610-zim7nond 525 14 in in IN cord-282610-zim7nond 525 15 a a DT cord-282610-zim7nond 525 16 manner manner NN cord-282610-zim7nond 525 17 that that WDT cord-282610-zim7nond 525 18 can can MD cord-282610-zim7nond 525 19 push push VB cord-282610-zim7nond 525 20 the the DT cord-282610-zim7nond 525 21 human human JJ cord-282610-zim7nond 525 22 holobiont holobiont NN cord-282610-zim7nond 525 23 toward toward IN cord-282610-zim7nond 525 24 a a DT cord-282610-zim7nond 525 25 state state NN cord-282610-zim7nond 525 26 of of IN cord-282610-zim7nond 525 27 illness illness NN cord-282610-zim7nond 525 28 . . . cord-282610-zim7nond 526 1 Studies study NNS cord-282610-zim7nond 526 2 of of IN cord-282610-zim7nond 526 3 microbiome microbiome NN cord-282610-zim7nond 526 4 dysbiosis dysbiosis NN cord-282610-zim7nond 526 5 in in IN cord-282610-zim7nond 526 6 ME ME NNP cord-282610-zim7nond 526 7 / / SYM cord-282610-zim7nond 526 8 CFS CFS NNP cord-282610-zim7nond 526 9 must must MD cord-282610-zim7nond 526 10 consider consider VB cord-282610-zim7nond 526 11 this this DT cord-282610-zim7nond 526 12 microbe microbe NN cord-282610-zim7nond 526 13 and and CC cord-282610-zim7nond 526 14 viral viral JJ cord-282610-zim7nond 526 15 activity activity NN cord-282610-zim7nond 526 16 . . . cord-282610-zim7nond 527 1 Most Most JJS cord-282610-zim7nond 527 2 human human JJ cord-282610-zim7nond 527 3 microbes microbe NNS cord-282610-zim7nond 527 4 can can MD cord-282610-zim7nond 527 5 alter alter VB cord-282610-zim7nond 527 6 their -PRON- PRP$ cord-282610-zim7nond 527 7 gene gene NN cord-282610-zim7nond 527 8 expression expression NN cord-282610-zim7nond 527 9 to to TO cord-282610-zim7nond 527 10 act act VB cord-282610-zim7nond 527 11 as as IN cord-282610-zim7nond 527 12 pathogens pathogen NNS cord-282610-zim7nond 527 13 under under IN cord-282610-zim7nond 527 14 conditions condition NNS cord-282610-zim7nond 527 15 of of IN cord-282610-zim7nond 527 16 imbalance imbalance NN cord-282610-zim7nond 527 17 and and CC cord-282610-zim7nond 527 18 immunosuppression immunosuppression NN cord-282610-zim7nond 527 19 . . . cord-282610-zim7nond 528 1 This this DT cord-282610-zim7nond 528 2 pathobiont pathobiont NN cord-282610-zim7nond 528 3 behavior behavior NN cord-282610-zim7nond 528 4 is be VBZ cord-282610-zim7nond 528 5 further further RB cord-282610-zim7nond 528 6 determined determine VBN cord-282610-zim7nond 528 7 by by IN cord-282610-zim7nond 528 8 the the DT cord-282610-zim7nond 528 9 activity activity NN cord-282610-zim7nond 528 10 and and CC cord-282610-zim7nond 528 11 virulence virulence NN cord-282610-zim7nond 528 12 of of IN cord-282610-zim7nond 528 13 neighboring neighboring NN cord-282610-zim7nond 528 14 microbes microbe NNS cord-282610-zim7nond 528 15 . . . cord-282610-zim7nond 529 1 Patients patient NNS cord-282610-zim7nond 529 2 with with IN cord-282610-zim7nond 529 3 ME ME NNP cord-282610-zim7nond 529 4 / / SYM cord-282610-zim7nond 529 5 CFS CFS NNP cord-282610-zim7nond 529 6 may may MD cord-282610-zim7nond 529 7 harbor harbor VB cord-282610-zim7nond 529 8 many many JJ cord-282610-zim7nond 529 9 of of IN cord-282610-zim7nond 529 10 the the DT cord-282610-zim7nond 529 11 same same JJ cord-282610-zim7nond 529 12 microbes microbe NNS cord-282610-zim7nond 529 13 and and CC cord-282610-zim7nond 529 14 viruses virus NNS cord-282610-zim7nond 529 15 as as IN cord-282610-zim7nond 529 16 heathy heathy JJ cord-282610-zim7nond 529 17 individuals individual NNS cord-282610-zim7nond 529 18 , , , cord-282610-zim7nond 529 19 yet yet CC cord-282610-zim7nond 529 20 these these DT cord-282610-zim7nond 529 21 pathobionts pathobiont NNS cord-282610-zim7nond 529 22 may may MD cord-282610-zim7nond 529 23 act act VB cord-282610-zim7nond 529 24 with with IN cord-282610-zim7nond 529 25 increased increase VBN cord-282610-zim7nond 529 26 virulence virulence NN cord-282610-zim7nond 529 27 in in IN cord-282610-zim7nond 529 28 patients patient NNS cord-282610-zim7nond 529 29 with with IN cord-282610-zim7nond 529 30 the the DT cord-282610-zim7nond 529 31 illness illness NN cord-282610-zim7nond 529 32 . . . cord-282610-zim7nond 530 1 Intracellular Intracellular NNP cord-282610-zim7nond 530 2 pathogens pathogen NNS cord-282610-zim7nond 530 3 , , , cord-282610-zim7nond 530 4 including include VBG cord-282610-zim7nond 530 5 several several JJ cord-282610-zim7nond 530 6 associated associate VBN cord-282610-zim7nond 530 7 with with IN cord-282610-zim7nond 530 8 ME ME NNP cord-282610-zim7nond 530 9 / / SYM cord-282610-zim7nond 530 10 CFS CFS NNP cord-282610-zim7nond 530 11 , , , cord-282610-zim7nond 530 12 have have VBP cord-282610-zim7nond 530 13 been be VBN cord-282610-zim7nond 530 14 shown show VBN cord-282610-zim7nond 530 15 to to TO cord-282610-zim7nond 530 16 directly directly RB cord-282610-zim7nond 530 17 interfere interfere VB cord-282610-zim7nond 530 18 with with IN cord-282610-zim7nond 530 19 human human JJ cord-282610-zim7nond 530 20 transcription transcription NN cord-282610-zim7nond 530 21 , , , cord-282610-zim7nond 530 22 translation translation NN cord-282610-zim7nond 530 23 , , , cord-282610-zim7nond 530 24 and and CC cord-282610-zim7nond 530 25 DNA dna NN cord-282610-zim7nond 530 26 repair repair NN cord-282610-zim7nond 530 27 processes process NNS cord-282610-zim7nond 530 28 . . . cord-282610-zim7nond 531 1 Molecular molecular JJ cord-282610-zim7nond 531 2 mimicry mimicry NN cord-282610-zim7nond 531 3 between between IN cord-282610-zim7nond 531 4 host host NN cord-282610-zim7nond 531 5 and and CC cord-282610-zim7nond 531 6 pathogen pathogen NN cord-282610-zim7nond 531 7 proteins protein NNS cord-282610-zim7nond 531 8 / / SYM cord-282610-zim7nond 531 9 metabolites metabolite NNS cord-282610-zim7nond 531 10 further further RB cord-282610-zim7nond 531 11 exacerbates exacerbate VBZ cord-282610-zim7nond 531 12 this this DT cord-282610-zim7nond 531 13 interference interference NN cord-282610-zim7nond 531 14 . . . cord-282610-zim7nond 532 1 Interacting interact VBG cord-282610-zim7nond 532 2 microbes microbe NNS cord-282610-zim7nond 532 3 can can MD cord-282610-zim7nond 532 4 also also RB cord-282610-zim7nond 532 5 drive drive VB cord-282610-zim7nond 532 6 disease disease NN cord-282610-zim7nond 532 7 by by IN cord-282610-zim7nond 532 8 changing change VBG cord-282610-zim7nond 532 9 their -PRON- PRP$ cord-282610-zim7nond 532 10 collective collective JJ cord-282610-zim7nond 532 11 gene gene NN cord-282610-zim7nond 532 12 expression expression NN cord-282610-zim7nond 532 13 . . . cord-282610-zim7nond 533 1 Other other JJ cord-282610-zim7nond 533 2 pathogens pathogen NNS cord-282610-zim7nond 533 3 disable disable VBP cord-282610-zim7nond 533 4 mitochondria mitochondrion NNS cord-282610-zim7nond 533 5 , , , cord-282610-zim7nond 533 6 or or CC cord-282610-zim7nond 533 7 may may MD cord-282610-zim7nond 533 8 infect infect VB cord-282610-zim7nond 533 9 central central JJ cord-282610-zim7nond 533 10 nervous nervous JJ cord-282610-zim7nond 533 11 system system NN cord-282610-zim7nond 533 12 tissue tissue NN cord-282610-zim7nond 533 13 in in IN cord-282610-zim7nond 533 14 ways way NNS cord-282610-zim7nond 533 15 that that WDT cord-282610-zim7nond 533 16 dysregulate dysregulate VBP cord-282610-zim7nond 533 17 signaling signal VBG cord-282610-zim7nond 533 18 via via IN cord-282610-zim7nond 533 19 the the DT cord-282610-zim7nond 533 20 gutbrain gutbrain NNP cord-282610-zim7nond 533 21 axis axis NN cord-282610-zim7nond 533 22 . . . cord-282610-zim7nond 534 1 Antibodies antibody NNS cord-282610-zim7nond 534 2 and/or and/or CC cord-282610-zim7nond 534 3 clonal clonal JJ cord-282610-zim7nond 534 4 T t NN cord-282610-zim7nond 534 5 cells cell NNS cord-282610-zim7nond 534 6 identified identify VBN cord-282610-zim7nond 534 7 in in IN cord-282610-zim7nond 534 8 patients patient NNS cord-282610-zim7nond 534 9 with with IN cord-282610-zim7nond 534 10 ME ME NNP cord-282610-zim7nond 534 11 / / SYM cord-282610-zim7nond 534 12 CFS CFS NNP cord-282610-zim7nond 534 13 are be VBP cord-282610-zim7nond 534 14 likely likely RB cord-282610-zim7nond 534 15 activated activate VBN cord-282610-zim7nond 534 16 in in IN cord-282610-zim7nond 534 17 response response NN cord-282610-zim7nond 534 18 to to IN cord-282610-zim7nond 534 19 many many JJ cord-282610-zim7nond 534 20 of of IN cord-282610-zim7nond 534 21 these these DT cord-282610-zim7nond 534 22 persistent persistent JJ cord-282610-zim7nond 534 23 microbiome microbiome NN cord-282610-zim7nond 534 24 pathogens pathogen NNS cord-282610-zim7nond 534 25 . . . cord-282610-zim7nond 535 1 Different different JJ cord-282610-zim7nond 535 2 pathogens pathogen NNS cord-282610-zim7nond 535 3 have have VBP cord-282610-zim7nond 535 4 evolved evolve VBN cord-282610-zim7nond 535 5 similar similar JJ cord-282610-zim7nond 535 6 survival survival NN cord-282610-zim7nond 535 7 mechanisms mechanism NNS cord-282610-zim7nond 535 8 to to TO cord-282610-zim7nond 535 9 disable disable VB cord-282610-zim7nond 535 10 the the DT cord-282610-zim7nond 535 11 host host NN cord-282610-zim7nond 535 12 immune immune JJ cord-282610-zim7nond 535 13 response response NN cord-282610-zim7nond 535 14 and/or and/or CC cord-282610-zim7nond 535 15 host host NN cord-282610-zim7nond 535 16 metabolic metabolic JJ cord-282610-zim7nond 535 17 pathways pathway NNS cord-282610-zim7nond 535 18 . . . cord-282610-zim7nond 536 1 The the DT cord-282610-zim7nond 536 2 metabolic metabolic JJ cord-282610-zim7nond 536 3 dysfunction dysfunction NN cord-282610-zim7nond 536 4 driven drive VBN cord-282610-zim7nond 536 5 by by IN cord-282610-zim7nond 536 6 these these DT cord-282610-zim7nond 536 7 different different JJ cord-282610-zim7nond 536 8 microbes microbe NNS cord-282610-zim7nond 536 9 can can MD cord-282610-zim7nond 536 10 result result VB cord-282610-zim7nond 536 11 in in IN cord-282610-zim7nond 536 12 similar similar JJ cord-282610-zim7nond 536 13 clusters cluster NNS cord-282610-zim7nond 536 14 of of IN cord-282610-zim7nond 536 15 inflammatory inflammatory JJ cord-282610-zim7nond 536 16 symptoms symptom NNS cord-282610-zim7nond 536 17 . . . cord-282610-zim7nond 537 1 ME ME NNP cord-282610-zim7nond 537 2 / / SYM cord-282610-zim7nond 537 3 CFS CFS NNP cord-282610-zim7nond 537 4 may may MD cord-282610-zim7nond 537 5 be be VB cord-282610-zim7nond 537 6 driven drive VBN cord-282610-zim7nond 537 7 by by IN cord-282610-zim7nond 537 8 this this DT cord-282610-zim7nond 537 9 pathogen pathogen NN cord-282610-zim7nond 537 10 - - HYPH cord-282610-zim7nond 537 11 induced induce VBN cord-282610-zim7nond 537 12 dysfunction dysfunction NN cord-282610-zim7nond 537 13 , , , cord-282610-zim7nond 537 14 with with IN cord-282610-zim7nond 537 15 the the DT cord-282610-zim7nond 537 16 nature nature NN cord-282610-zim7nond 537 17 of of IN cord-282610-zim7nond 537 18 dysbiosis dysbiosis NN cord-282610-zim7nond 537 19 and and CC cord-282610-zim7nond 537 20 symptom symptom NN cord-282610-zim7nond 537 21 presentation presentation NN cord-282610-zim7nond 537 22 varying vary VBG cord-282610-zim7nond 537 23 based base VBN cord-282610-zim7nond 537 24 on on IN cord-282610-zim7nond 537 25 a a DT cord-282610-zim7nond 537 26 patient patient NN cord-282610-zim7nond 537 27 's 's POS cord-282610-zim7nond 537 28 unique unique JJ cord-282610-zim7nond 537 29 infectious infectious JJ cord-282610-zim7nond 537 30 and and CC cord-282610-zim7nond 537 31 environmental environmental JJ cord-282610-zim7nond 537 32 history history NN cord-282610-zim7nond 537 33 . . . cord-282610-zim7nond 538 1 An an DT cord-282610-zim7nond 538 2 initial initial JJ cord-282610-zim7nond 538 3 infection infection NN cord-282610-zim7nond 538 4 or or CC cord-282610-zim7nond 538 5 environmental environmental JJ cord-282610-zim7nond 538 6 exposure exposure NN cord-282610-zim7nond 538 7 weakens weaken VBZ cord-282610-zim7nond 538 8 the the DT cord-282610-zim7nond 538 9 host host NN cord-282610-zim7nond 538 10 immune immune JJ cord-282610-zim7nond 538 11 system system NN cord-282610-zim7nond 538 12 . . . cord-282610-zim7nond 539 1 This this DT cord-282610-zim7nond 539 2 makes make VBZ cord-282610-zim7nond 539 3 it -PRON- PRP cord-282610-zim7nond 539 4 easier easy JJR cord-282610-zim7nond 539 5 for for IN cord-282610-zim7nond 539 6 pathobionts pathobiont NNS cord-282610-zim7nond 539 7 to to TO cord-282610-zim7nond 539 8 subvert subvert VB cord-282610-zim7nond 539 9 the the DT cord-282610-zim7nond 539 10 immune immune JJ cord-282610-zim7nond 539 11 response response NN cord-282610-zim7nond 539 12 and and CC cord-282610-zim7nond 539 13 interfere interfere VB cord-282610-zim7nond 539 14 with with IN cord-282610-zim7nond 539 15 host host NN cord-282610-zim7nond 539 16 gene gene NN cord-282610-zim7nond 539 17 expression expression NN cord-282610-zim7nond 539 18 and and CC cord-282610-zim7nond 539 19 metabolism metabolism NN cord-282610-zim7nond 539 20 . . . cord-282610-zim7nond 540 1 A a DT cord-282610-zim7nond 540 2 snowball snowball NN cord-282610-zim7nond 540 3 effect effect NN cord-282610-zim7nond 540 4 begins begin VBZ cord-282610-zim7nond 540 5 , , , cord-282610-zim7nond 540 6 in in IN cord-282610-zim7nond 540 7 which which WDT cord-282610-zim7nond 540 8 the the DT cord-282610-zim7nond 540 9 microbiome microbiome NN cord-282610-zim7nond 540 10 becomes become VBZ cord-282610-zim7nond 540 11 increasingly increasingly RB cord-282610-zim7nond 540 12 dysbiotic dysbiotic JJ cord-282610-zim7nond 540 13 as as IN cord-282610-zim7nond 540 14 the the DT cord-282610-zim7nond 540 15 strength strength NN cord-282610-zim7nond 540 16 of of IN cord-282610-zim7nond 540 17 the the DT cord-282610-zim7nond 540 18 immune immune JJ cord-282610-zim7nond 540 19 response response NN cord-282610-zim7nond 540 20 weakens weaken VBZ cord-282610-zim7nond 540 21 over over IN cord-282610-zim7nond 540 22 time time NN cord-282610-zim7nond 540 23 . . . cord-282610-zim7nond 541 1 The the DT cord-282610-zim7nond 541 2 unique unique JJ cord-282610-zim7nond 541 3 symptoms symptom NNS cord-282610-zim7nond 541 4 any any DT cord-282610-zim7nond 541 5 one one CD cord-282610-zim7nond 541 6 ME ME NNP cord-282610-zim7nond 541 7 / / SYM cord-282610-zim7nond 541 8 CFS CFS NNP cord-282610-zim7nond 541 9 patient patient NN cord-282610-zim7nond 541 10 develops develop VBZ cord-282610-zim7nond 541 11 are be VBP cord-282610-zim7nond 541 12 expected expect VBN cord-282610-zim7nond 541 13 to to TO cord-282610-zim7nond 541 14 vary vary VB cord-282610-zim7nond 541 15 depending depend VBG cord-282610-zim7nond 541 16 on on IN cord-282610-zim7nond 541 17 the the DT cord-282610-zim7nond 541 18 location location NN cord-282610-zim7nond 541 19 , , , cord-282610-zim7nond 541 20 species specie NNS cord-282610-zim7nond 541 21 , , , cord-282610-zim7nond 541 22 strain strain NN cord-282610-zim7nond 541 23 and and CC cord-282610-zim7nond 541 24 virulence virulence NN cord-282610-zim7nond 541 25 of of IN cord-282610-zim7nond 541 26 the the DT cord-282610-zim7nond 541 27 pathogens pathogen NNS cord-282610-zim7nond 541 28 driving drive VBG cord-282610-zim7nond 541 29 this this DT cord-282610-zim7nond 541 30 dysbiosis dysbiosis NN cord-282610-zim7nond 541 31 . . . cord-282610-zim7nond 542 1 Thus thus RB cord-282610-zim7nond 542 2 , , , cord-282610-zim7nond 542 3 while while IN cord-282610-zim7nond 542 4 certain certain JJ cord-282610-zim7nond 542 5 dominant dominant JJ cord-282610-zim7nond 542 6 or or CC cord-282610-zim7nond 542 7 keystone keystone JJ cord-282610-zim7nond 542 8 pathogens pathogen NNS cord-282610-zim7nond 542 9 may may MD cord-282610-zim7nond 542 10 be be VB cord-282610-zim7nond 542 11 identified identify VBN cord-282610-zim7nond 542 12 in in IN cord-282610-zim7nond 542 13 ME ME NNP cord-282610-zim7nond 542 14 / / SYM cord-282610-zim7nond 542 15 CFS CFS NNP cord-282610-zim7nond 542 16 , , , cord-282610-zim7nond 542 17 composition composition NN cord-282610-zim7nond 542 18 of of IN cord-282610-zim7nond 542 19 the the DT cord-282610-zim7nond 542 20 ME ME NNP cord-282610-zim7nond 542 21 / / SYM cord-282610-zim7nond 542 22 CFS CFS NNP cord-282610-zim7nond 542 23 microbiome microbiome NN cord-282610-zim7nond 542 24 , , , cord-282610-zim7nond 542 25 metabolome metabolome NNP cord-282610-zim7nond 542 26 , , , cord-282610-zim7nond 542 27 and and CC cord-282610-zim7nond 542 28 proteome proteome NN cord-282610-zim7nond 542 29 should should MD cord-282610-zim7nond 542 30 be be VB cord-282610-zim7nond 542 31 expected expect VBN cord-282610-zim7nond 542 32 to to TO cord-282610-zim7nond 542 33 differ differ VB cord-282610-zim7nond 542 34 somewhat somewhat RB cord-282610-zim7nond 542 35 among among IN cord-282610-zim7nond 542 36 individual individual JJ cord-282610-zim7nond 542 37 patients patient NNS cord-282610-zim7nond 542 38 . . . cord-282610-zim7nond 543 1 These these DT cord-282610-zim7nond 543 2 common common JJ cord-282610-zim7nond 543 3 mechanisms mechanism NNS cord-282610-zim7nond 543 4 suggest suggest VBP cord-282610-zim7nond 543 5 that that IN cord-282610-zim7nond 543 6 ME ME NNP cord-282610-zim7nond 543 7 / / SYM cord-282610-zim7nond 543 8 CFS CFS NNP cord-282610-zim7nond 543 9 is be VBZ cord-282610-zim7nond 543 10 best well RBS cord-282610-zim7nond 543 11 studied study VBN cord-282610-zim7nond 543 12 in in IN cord-282610-zim7nond 543 13 concert concert NN cord-282610-zim7nond 543 14 with with IN cord-282610-zim7nond 543 15 other other JJ cord-282610-zim7nond 543 16 chronic chronic JJ cord-282610-zim7nond 543 17 conditions condition NNS cord-282610-zim7nond 543 18 tied tie VBN cord-282610-zim7nond 543 19 to to IN cord-282610-zim7nond 543 20 microbiome microbiome NN cord-282610-zim7nond 543 21 dysbiosis dysbiosis NN cord-282610-zim7nond 543 22 , , , cord-282610-zim7nond 543 23 persistent persistent JJ cord-282610-zim7nond 543 24 infection infection NN cord-282610-zim7nond 543 25 and and CC cord-282610-zim7nond 543 26 adverse adverse JJ cord-282610-zim7nond 543 27 environmental environmental JJ cord-282610-zim7nond 543 28 exposure exposure NN cord-282610-zim7nond 543 29 . . . cord-282610-zim7nond 544 1 These these DT cord-282610-zim7nond 544 2 include include VBP cord-282610-zim7nond 544 3 fibromyalgia fibromyalgia NN cord-282610-zim7nond 544 4 and and CC cord-282610-zim7nond 544 5 Gulf Gulf NNP cord-282610-zim7nond 544 6 War War NNP cord-282610-zim7nond 544 7 Syndrome Syndrome NNP cord-282610-zim7nond 544 8 , , , cord-282610-zim7nond 544 9 but but CC cord-282610-zim7nond 544 10 also also RB cord-282610-zim7nond 544 11 conditions condition NNS cord-282610-zim7nond 544 12 like like IN cord-282610-zim7nond 544 13 Post Post NNP cord-282610-zim7nond 544 14 - - NNP cord-282610-zim7nond 544 15 Ebola Ebola NNP cord-282610-zim7nond 544 16 Syndrome Syndrome NNP cord-282610-zim7nond 544 17 in in IN cord-282610-zim7nond 544 18 which which WDT cord-282610-zim7nond 544 19 severe severe JJ cord-282610-zim7nond 544 20 chronic chronic JJ cord-282610-zim7nond 544 21 symptoms symptom NNS cord-282610-zim7nond 544 22 develop develop VBP cord-282610-zim7nond 544 23 after after IN cord-282610-zim7nond 544 24 infection infection NN cord-282610-zim7nond 544 25 with with IN cord-282610-zim7nond 544 26 an an DT cord-282610-zim7nond 544 27 " " `` cord-282610-zim7nond 544 28 acute acute JJ cord-282610-zim7nond 544 29 " " '' cord-282610-zim7nond 544 30 infectious infectious JJ cord-282610-zim7nond 544 31 agent agent NN cord-282610-zim7nond 544 32 that that WDT cord-282610-zim7nond 544 33 is be VBZ cord-282610-zim7nond 544 34 able able JJ cord-282610-zim7nond 544 35 to to TO cord-282610-zim7nond 544 36 persist persist VB cord-282610-zim7nond 544 37 in in IN cord-282610-zim7nond 544 38 latent latent JJ cord-282610-zim7nond 544 39 forms form NNS cord-282610-zim7nond 544 40 . . . cord-282610-zim7nond 545 1 Treatments treatment NNS cord-282610-zim7nond 545 2 that that WDT cord-282610-zim7nond 545 3 support support VBP cord-282610-zim7nond 545 4 or or CC cord-282610-zim7nond 545 5 activate activate VB cord-282610-zim7nond 545 6 the the DT cord-282610-zim7nond 545 7 human human JJ cord-282610-zim7nond 545 8 immune immune JJ cord-282610-zim7nond 545 9 system system NN cord-282610-zim7nond 545 10 could could MD cord-282610-zim7nond 545 11 allow allow VB cord-282610-zim7nond 545 12 ME ME NNP cord-282610-zim7nond 545 13 / / SYM cord-282610-zim7nond 545 14 CFS CFS NNP cord-282610-zim7nond 545 15 patients patient NNS cord-282610-zim7nond 545 16 to to TO cord-282610-zim7nond 545 17 improve improve VB cord-282610-zim7nond 545 18 microbiome microbiome NN cord-282610-zim7nond 545 19 health health NN cord-282610-zim7nond 545 20 by by IN cord-282610-zim7nond 545 21 better well JJR cord-282610-zim7nond 545 22 targeting target VBG cord-282610-zim7nond 545 23 pathogens pathogen NNS cord-282610-zim7nond 545 24 over over IN cord-282610-zim7nond 545 25 time time NN cord-282610-zim7nond 545 26 . . . cord-282610-zim7nond 546 1 Like like IN cord-282610-zim7nond 546 2 the the DT cord-282610-zim7nond 546 3 novel novel JJ cord-282610-zim7nond 546 4 immunotherapies immunotherapy NNS cord-282610-zim7nond 546 5 being be VBG cord-282610-zim7nond 546 6 developed develop VBN cord-282610-zim7nond 546 7 for for IN cord-282610-zim7nond 546 8 cancers cancer NNS cord-282610-zim7nond 546 9 , , , cord-282610-zim7nond 546 10 these these DT cord-282610-zim7nond 546 11 immunostimulative immunostimulative JJ cord-282610-zim7nond 546 12 therapies therapy NNS cord-282610-zim7nond 546 13 would would MD cord-282610-zim7nond 546 14 be be VB cord-282610-zim7nond 546 15 expected expect VBN cord-282610-zim7nond 546 16 to to TO cord-282610-zim7nond 546 17 generate generate VB cord-282610-zim7nond 546 18 temporary temporary JJ cord-282610-zim7nond 546 19 immunopathology immunopathology NN cord-282610-zim7nond 546 20 . . . cord-282610-zim7nond 547 1 Institutional institutional JJ cord-282610-zim7nond 547 2 reviewers reviewer NNS cord-282610-zim7nond 547 3 hesitant hesitant JJ cord-282610-zim7nond 547 4 to to TO cord-282610-zim7nond 547 5 approve approve VB cord-282610-zim7nond 547 6 immunopathology immunopathology NN cord-282610-zim7nond 547 7 - - HYPH cord-282610-zim7nond 547 8 based base VBN cord-282610-zim7nond 547 9 therapies therapy NNS cord-282610-zim7nond 547 10 should should MD cord-282610-zim7nond 547 11 consider consider VB cord-282610-zim7nond 547 12 that that IN cord-282610-zim7nond 547 13 ME ME NNP cord-282610-zim7nond 547 14 / / SYM cord-282610-zim7nond 547 15 CFS CFS NNP cord-282610-zim7nond 547 16 quality quality NN cord-282610-zim7nond 547 17 of of IN cord-282610-zim7nond 547 18 life life NN cord-282610-zim7nond 547 19 is be VBZ cord-282610-zim7nond 547 20 typically typically RB cord-282610-zim7nond 547 21 very very RB cord-282610-zim7nond 547 22 low low JJ cord-282610-zim7nond 547 23 , , , cord-282610-zim7nond 547 24 with with IN cord-282610-zim7nond 547 25 patients patient NNS cord-282610-zim7nond 547 26 demonstrating demonstrate VBG cord-282610-zim7nond 547 27 a a DT cord-282610-zim7nond 547 28 substantial substantial JJ cord-282610-zim7nond 547 29 increase increase NN cord-282610-zim7nond 547 30 in in IN cord-282610-zim7nond 547 31 mortality mortality NN cord-282610-zim7nond 547 32 from from IN cord-282610-zim7nond 547 33 suicide suicide NN cord-282610-zim7nond 547 34 ( ( -LRB- cord-282610-zim7nond 547 35 202 202 CD cord-282610-zim7nond 547 36 ) ) -RRB- cord-282610-zim7nond 547 37 . . . cord-282610-zim7nond 548 1 It -PRON- PRP cord-282610-zim7nond 548 2 often often RB cord-282610-zim7nond 548 3 takes take VBZ cord-282610-zim7nond 548 4 patients patient NNS cord-282610-zim7nond 548 5 years year NNS cord-282610-zim7nond 548 6 to to TO cord-282610-zim7nond 548 7 receive receive VB cord-282610-zim7nond 548 8 a a DT cord-282610-zim7nond 548 9 diagnosis diagnosis NN cord-282610-zim7nond 548 10 of of IN cord-282610-zim7nond 548 11 ME ME NNP cord-282610-zim7nond 548 12 / / SYM cord-282610-zim7nond 548 13 CFS CFS NNP cord-282610-zim7nond 548 14 . . . cord-282610-zim7nond 549 1 This this DT cord-282610-zim7nond 549 2 delay delay NN cord-282610-zim7nond 549 3 wastes waste VBZ cord-282610-zim7nond 549 4 a a DT cord-282610-zim7nond 549 5 valuable valuable JJ cord-282610-zim7nond 549 6 period period NN cord-282610-zim7nond 549 7 during during IN cord-282610-zim7nond 549 8 which which WDT cord-282610-zim7nond 549 9 the the DT cord-282610-zim7nond 549 10 immune immune JJ cord-282610-zim7nond 549 11 system system NN cord-282610-zim7nond 549 12 is be VBZ cord-282610-zim7nond 549 13 most most RBS cord-282610-zim7nond 549 14 responsive responsive JJ cord-282610-zim7nond 549 15 to to IN cord-282610-zim7nond 549 16 immunostimulatory immunostimulatory NNP cord-282610-zim7nond 549 17 treatment treatment NN cord-282610-zim7nond 549 18 . . . cord-282610-zim7nond 550 1 Patients patient NNS cord-282610-zim7nond 550 2 treated treat VBN cord-282610-zim7nond 550 3 during during IN cord-282610-zim7nond 550 4 earlier early JJR cord-282610-zim7nond 550 5 stage stage NN cord-282610-zim7nond 550 6 disease disease NN cord-282610-zim7nond 550 7 are be VBP cord-282610-zim7nond 550 8 also also RB cord-282610-zim7nond 550 9 less less RBR cord-282610-zim7nond 550 10 likely likely JJ cord-282610-zim7nond 550 11 to to TO cord-282610-zim7nond 550 12 experience experience VB cord-282610-zim7nond 550 13 severe severe JJ cord-282610-zim7nond 550 14 or or CC cord-282610-zim7nond 550 15 long long RB cord-282610-zim7nond 550 16 - - HYPH cord-282610-zim7nond 550 17 lasting last VBG cord-282610-zim7nond 550 18 immunopathology immunopathology NN cord-282610-zim7nond 550 19 . . . cord-282610-zim7nond 551 1 This this DT cord-282610-zim7nond 551 2 suggests suggest VBZ cord-282610-zim7nond 551 3 that that IN cord-282610-zim7nond 551 4 immunostimulative immunostimulative JJ cord-282610-zim7nond 551 5 therapies therapy NNS cord-282610-zim7nond 551 6 should should MD cord-282610-zim7nond 551 7 be be VB cord-282610-zim7nond 551 8 administered administer VBN cord-282610-zim7nond 551 9 in in IN cord-282610-zim7nond 551 10 a a DT cord-282610-zim7nond 551 11 predictive predictive JJ cord-282610-zim7nond 551 12 and and CC cord-282610-zim7nond 551 13 even even RB cord-282610-zim7nond 551 14 preventative preventative JJ cord-282610-zim7nond 551 15 fashion fashion NN cord-282610-zim7nond 551 16 . . . cord-282610-zim7nond 552 1 In in IN cord-282610-zim7nond 552 2 addition addition NN cord-282610-zim7nond 552 3 , , , cord-282610-zim7nond 552 4 interventions intervention NNS cord-282610-zim7nond 552 5 or or CC cord-282610-zim7nond 552 6 treatments treatment NNS cord-282610-zim7nond 552 7 that that WDT cord-282610-zim7nond 552 8 might may MD cord-282610-zim7nond 552 9 help help VB cord-282610-zim7nond 552 10 patients patient NNS cord-282610-zim7nond 552 11 better well RBR cord-282610-zim7nond 552 12 manage manage VB cord-282610-zim7nond 552 13 the the DT cord-282610-zim7nond 552 14 byproducts byproduct NNS cord-282610-zim7nond 552 15 of of IN cord-282610-zim7nond 552 16 immunopathology immunopathology NN cord-282610-zim7nond 552 17 ( ( -LRB- cord-282610-zim7nond 552 18 bacterial bacterial JJ cord-282610-zim7nond 552 19 LPS lp NNS cord-282610-zim7nond 552 20 etc etc FW cord-282610-zim7nond 552 21 . . . cord-282610-zim7nond 552 22 ) ) -RRB- cord-282610-zim7nond 552 23 should should MD cord-282610-zim7nond 552 24 become become VB cord-282610-zim7nond 552 25 a a DT cord-282610-zim7nond 552 26 priority priority NN cord-282610-zim7nond 552 27 for for IN cord-282610-zim7nond 552 28 the the DT cord-282610-zim7nond 552 29 research research NN cord-282610-zim7nond 552 30 community community NN cord-282610-zim7nond 552 31 . . . cord-282610-zim7nond 553 1 The the DT cord-282610-zim7nond 553 2 overall overall JJ cord-282610-zim7nond 553 3 success success NN cord-282610-zim7nond 553 4 of of IN cord-282610-zim7nond 553 5 ME ME NNP cord-282610-zim7nond 553 6 / / SYM cord-282610-zim7nond 553 7 CFS CFS NNP cord-282610-zim7nond 553 8 research research NN cord-282610-zim7nond 553 9 also also RB cord-282610-zim7nond 553 10 hinges hinge VBZ cord-282610-zim7nond 553 11 on on IN cord-282610-zim7nond 553 12 the the DT cord-282610-zim7nond 553 13 scientific scientific JJ cord-282610-zim7nond 553 14 community community NN cord-282610-zim7nond 553 15 's 's POS cord-282610-zim7nond 553 16 willingness willingness NN cord-282610-zim7nond 553 17 to to TO cord-282610-zim7nond 553 18 embrace embrace VB cord-282610-zim7nond 553 19 the the DT cord-282610-zim7nond 553 20 concept concept NN cord-282610-zim7nond 553 21 of of IN cord-282610-zim7nond 553 22 the the DT cord-282610-zim7nond 553 23 human human JJ cord-282610-zim7nond 553 24 holobiont holobiont NN cord-282610-zim7nond 553 25 . . . cord-282610-zim7nond 554 1 In in IN cord-282610-zim7nond 554 2 ME ME NNP cord-282610-zim7nond 554 3 / / SYM cord-282610-zim7nond 554 4 CFS CFS NNP cord-282610-zim7nond 554 5 , , , cord-282610-zim7nond 554 6 the the DT cord-282610-zim7nond 554 7 immune immune JJ cord-282610-zim7nond 554 8 response response NN cord-282610-zim7nond 554 9 , , , cord-282610-zim7nond 554 10 metabolism metabolism NN cord-282610-zim7nond 554 11 , , , cord-282610-zim7nond 554 12 central central JJ cord-282610-zim7nond 554 13 nervous nervous JJ cord-282610-zim7nond 554 14 system system NN cord-282610-zim7nond 554 15 , , , cord-282610-zim7nond 554 16 and and CC cord-282610-zim7nond 554 17 human human JJ cord-282610-zim7nond 554 18 gene gene NN cord-282610-zim7nond 554 19 expression expression NN cord-282610-zim7nond 554 20 are be VBP cord-282610-zim7nond 554 21 all all DT cord-282610-zim7nond 554 22 linked link VBN cord-282610-zim7nond 554 23 by by IN cord-282610-zim7nond 554 24 the the DT cord-282610-zim7nond 554 25 activity activity NN cord-282610-zim7nond 554 26 of of IN cord-282610-zim7nond 554 27 the the DT cord-282610-zim7nond 554 28 microbiome microbiome NN cord-282610-zim7nond 554 29 and and CC cord-282610-zim7nond 554 30 its -PRON- PRP$ cord-282610-zim7nond 554 31 associated associate VBN cord-282610-zim7nond 554 32 proteins protein NNS cord-282610-zim7nond 554 33 / / SYM cord-282610-zim7nond 554 34 metabolites metabolite NNS cord-282610-zim7nond 554 35 . . . cord-282610-zim7nond 555 1 A a DT cord-282610-zim7nond 555 2 greater great JJR cord-282610-zim7nond 555 3 focus focus NN cord-282610-zim7nond 555 4 on on IN cord-282610-zim7nond 555 5 these these DT cord-282610-zim7nond 555 6 interconnected interconnect VBN cord-282610-zim7nond 555 7 systems system NNS cord-282610-zim7nond 555 8 is be VBZ cord-282610-zim7nond 555 9 necessary necessary JJ cord-282610-zim7nond 555 10 , , , cord-282610-zim7nond 555 11 which which WDT cord-282610-zim7nond 555 12 will will MD cord-282610-zim7nond 555 13 require require VB cord-282610-zim7nond 555 14 increased increase VBN cord-282610-zim7nond 555 15 collaboration collaboration NN cord-282610-zim7nond 555 16 between between IN cord-282610-zim7nond 555 17 separate separate JJ cord-282610-zim7nond 555 18 research research NN cord-282610-zim7nond 555 19 teams team NNS cord-282610-zim7nond 555 20 . . . cord-282610-zim7nond 556 1 AP AP NNP cord-282610-zim7nond 556 2 drafted draft VBD cord-282610-zim7nond 556 3 the the DT cord-282610-zim7nond 556 4 manuscript manuscript NN cord-282610-zim7nond 556 5 , , , cord-282610-zim7nond 556 6 analyzed analyze VBD cord-282610-zim7nond 556 7 and and CC cord-282610-zim7nond 556 8 interpreted interpret VBD cord-282610-zim7nond 556 9 data datum NNS cord-282610-zim7nond 556 10 , , , cord-282610-zim7nond 556 11 and and CC cord-282610-zim7nond 556 12 revised revise VBD cord-282610-zim7nond 556 13 the the DT cord-282610-zim7nond 556 14 manuscript manuscript NN cord-282610-zim7nond 556 15 for for IN cord-282610-zim7nond 556 16 critically critically RB cord-282610-zim7nond 556 17 important important JJ cord-282610-zim7nond 556 18 intellectual intellectual JJ cord-282610-zim7nond 556 19 content content NN cord-282610-zim7nond 556 20 . . . cord-282610-zim7nond 557 1 TM TM NNP cord-282610-zim7nond 557 2 drafted draft VBD cord-282610-zim7nond 557 3 parts part NNS cord-282610-zim7nond 557 4 of of IN cord-282610-zim7nond 557 5 the the DT cord-282610-zim7nond 557 6 manuscript manuscript NN cord-282610-zim7nond 557 7 , , , cord-282610-zim7nond 557 8 analyzed analyze VBD cord-282610-zim7nond 557 9 / / SYM cord-282610-zim7nond 557 10 interpreted interpret VBD cord-282610-zim7nond 557 11 data datum NNS cord-282610-zim7nond 557 12 and and CC cord-282610-zim7nond 557 13 revised revise VBD cord-282610-zim7nond 557 14 the the DT cord-282610-zim7nond 557 15 manuscript manuscript NN cord-282610-zim7nond 557 16 for for IN cord-282610-zim7nond 557 17 critically critically RB cord-282610-zim7nond 557 18 important important JJ cord-282610-zim7nond 557 19 intellectual intellectual JJ cord-282610-zim7nond 557 20 content content NN cord-282610-zim7nond 557 21 . . . cord-282610-zim7nond 558 1 Bacterial bacterial JJ cord-282610-zim7nond 558 2 persistence persistence NN cord-282610-zim7nond 558 3 and and CC cord-282610-zim7nond 558 4 expression expression NN cord-282610-zim7nond 558 5 of of IN cord-282610-zim7nond 558 6 disease disease NN cord-282610-zim7nond 558 7 Myalgic Myalgic NNP cord-282610-zim7nond 558 8 encephalomyelitis encephalomyelitis NN cord-282610-zim7nond 558 9 / / SYM cord-282610-zim7nond 558 10 chronic chronic JJ cord-282610-zim7nond 558 11 fatigue fatigue NN cord-282610-zim7nond 558 12 syndrome syndrome NN cord-282610-zim7nond 558 13 diagnosis diagnosis NN cord-282610-zim7nond 558 14 and and CC cord-282610-zim7nond 558 15 management management NN cord-282610-zim7nond 558 16 in in IN cord-282610-zim7nond 558 17 young young JJ cord-282610-zim7nond 558 18 people people NNS cord-282610-zim7nond 558 19 : : : cord-282610-zim7nond 558 20 a a DT cord-282610-zim7nond 558 21 primer primer NN cord-282610-zim7nond 558 22 . . . cord-282610-zim7nond 559 1 Front Front NNP cord-282610-zim7nond 559 2 Pediatr Pediatr NNP cord-282610-zim7nond 559 3 Association Association NNP cord-282610-zim7nond 559 4 of of IN cord-282610-zim7nond 559 5 active active JJ cord-282610-zim7nond 559 6 human human JJ cord-282610-zim7nond 559 7 herpesvirus-6,−7 herpesvirus-6,−7 NNS cord-282610-zim7nond 559 8 and and CC cord-282610-zim7nond 559 9 parvovirus parvovirus NN cord-282610-zim7nond 559 10 b19 b19 CD cord-282610-zim7nond 559 11 infection infection NN cord-282610-zim7nond 559 12 with with IN cord-282610-zim7nond 559 13 clinical clinical JJ cord-282610-zim7nond 559 14 outcomes outcome NNS cord-282610-zim7nond 559 15 in in IN cord-282610-zim7nond 559 16 patients patient NNS cord-282610-zim7nond 559 17 with with IN cord-282610-zim7nond 559 18 myalgic myalgic JJ cord-282610-zim7nond 559 19 encephalomyelitis encephalomyelitis NN cord-282610-zim7nond 559 20 / / SYM cord-282610-zim7nond 559 21 chronic chronic JJ cord-282610-zim7nond 559 22 fatigue fatigue NN cord-282610-zim7nond 559 23 syndrome syndrome NN cord-282610-zim7nond 559 24 Antibodies Antibodies NNP cord-282610-zim7nond 559 25 to to IN cord-282610-zim7nond 559 26 β β NN cord-282610-zim7nond 559 27 adrenergic adrenergic JJ cord-282610-zim7nond 559 28 and and CC cord-282610-zim7nond 559 29 muscarinic muscarinic JJ cord-282610-zim7nond 559 30 cholinergic cholinergic JJ cord-282610-zim7nond 559 31 receptors receptor NNS cord-282610-zim7nond 559 32 in in IN cord-282610-zim7nond 559 33 patients patient NNS cord-282610-zim7nond 559 34 with with IN cord-282610-zim7nond 559 35 Chronic Chronic NNP cord-282610-zim7nond 559 36 Fatigue Fatigue NNP cord-282610-zim7nond 559 37 Syndrome Syndrome NNP cord-282610-zim7nond 559 38 Distinct distinct JJ cord-282610-zim7nond 559 39 plasma plasma NN cord-282610-zim7nond 559 40 immune immune JJ cord-282610-zim7nond 559 41 signatures signature NNS cord-282610-zim7nond 559 42 in in IN cord-282610-zim7nond 559 43 ME ME NNP cord-282610-zim7nond 559 44 / / SYM cord-282610-zim7nond 559 45 CFS CFS NNP cord-282610-zim7nond 559 46 are be VBP cord-282610-zim7nond 559 47 present present JJ cord-282610-zim7nond 559 48 early early RB cord-282610-zim7nond 559 49 in in IN cord-282610-zim7nond 559 50 the the DT cord-282610-zim7nond 559 51 course course NN cord-282610-zim7nond 559 52 of of IN cord-282610-zim7nond 559 53 illness illness NN cord-282610-zim7nond 559 54 Cytokine cytokine NN cord-282610-zim7nond 559 55 signature signature NN cord-282610-zim7nond 559 56 associated associate VBN cord-282610-zim7nond 559 57 with with IN cord-282610-zim7nond 559 58 disease disease NN cord-282610-zim7nond 559 59 severity severity NN cord-282610-zim7nond 559 60 in in IN cord-282610-zim7nond 559 61 chronic chronic JJ cord-282610-zim7nond 559 62 fatigue fatigue NN cord-282610-zim7nond 559 63 syndrome syndrome NN cord-282610-zim7nond 559 64 patients patient NNS cord-282610-zim7nond 559 65 Chronic Chronic NNP cord-282610-zim7nond 559 66 fatigue fatigue NN cord-282610-zim7nond 559 67 syndrome syndrome NN cord-282610-zim7nond 559 68 and and CC cord-282610-zim7nond 559 69 mitochondrial mitochondrial JJ cord-282610-zim7nond 559 70 dysfunction dysfunction NN cord-282610-zim7nond 559 71 Viruses virus NNS cord-282610-zim7nond 559 72 as as IN cord-282610-zim7nond 559 73 modulators modulator NNS cord-282610-zim7nond 559 74 of of IN cord-282610-zim7nond 559 75 mitochondrial mitochondrial NN cord-282610-zim7nond 559 76 functions function NNS cord-282610-zim7nond 560 1 Hijacking hijacking NN cord-282610-zim7nond 560 2 mitochondria mitochondrion NNS cord-282610-zim7nond 560 3 : : : cord-282610-zim7nond 560 4 bacterial bacterial JJ cord-282610-zim7nond 560 5 toxins toxin NNS cord-282610-zim7nond 560 6 that that WDT cord-282610-zim7nond 560 7 modulate modulate VBP cord-282610-zim7nond 560 8 mitochondrial mitochondrial JJ cord-282610-zim7nond 560 9 function function NN cord-282610-zim7nond 560 10 Chronic Chronic NNP cord-282610-zim7nond 560 11 fatigue fatigue NN cord-282610-zim7nond 560 12 syndrome syndrome NN cord-282610-zim7nond 560 13 after after IN cord-282610-zim7nond 560 14 human human JJ cord-282610-zim7nond 560 15 parvovirus parvovirus NN cord-282610-zim7nond 560 16 B19 B19 NNP cord-282610-zim7nond 560 17 infection infection NN cord-282610-zim7nond 560 18 without without IN cord-282610-zim7nond 560 19 persistent persistent JJ cord-282610-zim7nond 560 20 viremia viremia NN cord-282610-zim7nond 560 21 Strains strain NNS cord-282610-zim7nond 560 22 , , , cord-282610-zim7nond 560 23 functions function NNS cord-282610-zim7nond 560 24 and and CC cord-282610-zim7nond 560 25 dynamics dynamic NNS cord-282610-zim7nond 560 26 in in IN cord-282610-zim7nond 560 27 the the DT cord-282610-zim7nond 560 28 expanded expand VBN cord-282610-zim7nond 560 29 Human Human NNP cord-282610-zim7nond 560 30 Microbiome Microbiome NNP cord-282610-zim7nond 560 31 Project Project NNP cord-282610-zim7nond 560 32 Current current JJ cord-282610-zim7nond 560 33 understanding understanding NN cord-282610-zim7nond 560 34 of of IN cord-282610-zim7nond 560 35 the the DT cord-282610-zim7nond 560 36 human human JJ cord-282610-zim7nond 560 37 microbiome microbiome NN cord-282610-zim7nond 561 1 The the DT cord-282610-zim7nond 561 2 emerging emerge VBG cord-282610-zim7nond 561 3 world world NN cord-282610-zim7nond 561 4 of of IN cord-282610-zim7nond 561 5 the the DT cord-282610-zim7nond 561 6 fungal fungal NN cord-282610-zim7nond 561 7 microbiome microbiome NN cord-282610-zim7nond 562 1 Numerous numerous JJ cord-282610-zim7nond 562 2 uncharacterized uncharacterized JJ cord-282610-zim7nond 562 3 and and CC cord-282610-zim7nond 562 4 highly highly RB cord-282610-zim7nond 562 5 divergent divergent JJ cord-282610-zim7nond 562 6 microbes microbe NNS cord-282610-zim7nond 562 7 which which WDT cord-282610-zim7nond 562 8 colonize colonize VBP cord-282610-zim7nond 562 9 humans human NNS cord-282610-zim7nond 562 10 are be VBP cord-282610-zim7nond 562 11 revealed reveal VBN cord-282610-zim7nond 562 12 by by IN cord-282610-zim7nond 562 13 circulating circulate VBG cord-282610-zim7nond 562 14 cell cell NN cord-282610-zim7nond 562 15 - - HYPH cord-282610-zim7nond 562 16 free free JJ cord-282610-zim7nond 562 17 DNA dna NN cord-282610-zim7nond 562 18 Humans Humans NNPS cord-282610-zim7nond 562 19 as as IN cord-282610-zim7nond 562 20 holobionts holobiont NNS cord-282610-zim7nond 562 21 : : : cord-282610-zim7nond 562 22 implications implication NNS cord-282610-zim7nond 562 23 for for IN cord-282610-zim7nond 562 24 prevention prevention NN cord-282610-zim7nond 562 25 and and CC cord-282610-zim7nond 562 26 therapy therapy NN cord-282610-zim7nond 562 27 Understanding understand VBG cord-282610-zim7nond 562 28 the the DT cord-282610-zim7nond 562 29 Holobiont holobiont NN cord-282610-zim7nond 562 30 : : : cord-282610-zim7nond 562 31 how how WRB cord-282610-zim7nond 562 32 microbial microbial JJ cord-282610-zim7nond 562 33 metabolites metabolite NNS cord-282610-zim7nond 562 34 affect affect VBP cord-282610-zim7nond 562 35 human human JJ cord-282610-zim7nond 562 36 health health NN cord-282610-zim7nond 562 37 and and CC cord-282610-zim7nond 562 38 shape shape VB cord-282610-zim7nond 562 39 the the DT cord-282610-zim7nond 562 40 immune immune JJ cord-282610-zim7nond 562 41 system system NN cord-282610-zim7nond 562 42 From from IN cord-282610-zim7nond 562 43 gut gut NN cord-282610-zim7nond 562 44 dysbiosis dysbiosis NN cord-282610-zim7nond 562 45 to to IN cord-282610-zim7nond 562 46 altered altered JJ cord-282610-zim7nond 562 47 brain brain NN cord-282610-zim7nond 562 48 function function NN cord-282610-zim7nond 562 49 and and CC cord-282610-zim7nond 562 50 mental mental JJ cord-282610-zim7nond 562 51 illness illness NN cord-282610-zim7nond 562 52 : : : cord-282610-zim7nond 562 53 mechanisms mechanism NNS cord-282610-zim7nond 562 54 and and CC cord-282610-zim7nond 562 55 pathways pathway NNS cord-282610-zim7nond 562 56 Dysbiosis Dysbiosis NNP cord-282610-zim7nond 562 57 may may MD cord-282610-zim7nond 562 58 trigger trigger VB cord-282610-zim7nond 562 59 autoimmune autoimmune JJ cord-282610-zim7nond 562 60 diseases disease NNS cord-282610-zim7nond 562 61 via via IN cord-282610-zim7nond 562 62 inappropriate inappropriate JJ cord-282610-zim7nond 562 63 post post JJ cord-282610-zim7nond 562 64 - - JJ cord-282610-zim7nond 562 65 translational translational JJ cord-282610-zim7nond 562 66 modification modification NN cord-282610-zim7nond 562 67 of of IN cord-282610-zim7nond 562 68 host host NN cord-282610-zim7nond 562 69 proteins protein NNS cord-282610-zim7nond 562 70 Microbiota Microbiota NNP cord-282610-zim7nond 562 71 dysbiosis dysbiosis NN cord-282610-zim7nond 562 72 in in IN cord-282610-zim7nond 562 73 select select JJ cord-282610-zim7nond 562 74 human human JJ cord-282610-zim7nond 562 75 cancers cancer NNS cord-282610-zim7nond 562 76 : : : cord-282610-zim7nond 562 77 evidence evidence NN cord-282610-zim7nond 562 78 of of IN cord-282610-zim7nond 562 79 association association NN cord-282610-zim7nond 562 80 and and CC cord-282610-zim7nond 562 81 causality causality NN cord-282610-zim7nond 563 1 No no DT cord-282610-zim7nond 563 2 effects effect NNS cord-282610-zim7nond 563 3 without without IN cord-282610-zim7nond 563 4 causes cause NNS cord-282610-zim7nond 563 5 : : : cord-282610-zim7nond 563 6 the the DT cord-282610-zim7nond 563 7 iron iron NN cord-282610-zim7nond 563 8 dysregulation dysregulation NN cord-282610-zim7nond 563 9 and and CC cord-282610-zim7nond 563 10 dormant dormant JJ cord-282610-zim7nond 563 11 microbes microbe NNS cord-282610-zim7nond 563 12 hypothesis hypothesis NN cord-282610-zim7nond 563 13 for for IN cord-282610-zim7nond 563 14 chronic chronic JJ cord-282610-zim7nond 563 15 , , , cord-282610-zim7nond 563 16 inflammatory inflammatory JJ cord-282610-zim7nond 563 17 diseases disease NNS cord-282610-zim7nond 564 1 Reduced reduced JJ cord-282610-zim7nond 564 2 diversity diversity NN cord-282610-zim7nond 564 3 and and CC cord-282610-zim7nond 564 4 altered altered JJ cord-282610-zim7nond 564 5 composition composition NN cord-282610-zim7nond 564 6 of of IN cord-282610-zim7nond 564 7 the the DT cord-282610-zim7nond 564 8 gut gut NN cord-282610-zim7nond 564 9 microbiome microbiome NN cord-282610-zim7nond 564 10 in in IN cord-282610-zim7nond 564 11 individuals individual NNS cord-282610-zim7nond 564 12 with with IN cord-282610-zim7nond 564 13 myalgic myalgic JJ cord-282610-zim7nond 564 14 encephalomyelitis encephalomyelitis NN cord-282610-zim7nond 564 15 / / SYM cord-282610-zim7nond 564 16 chronic chronic JJ cord-282610-zim7nond 564 17 fatigue fatigue NN cord-282610-zim7nond 564 18 syndrome syndrome NN cord-282610-zim7nond 564 19 Microbe microbe NN cord-282610-zim7nond 564 20 - - HYPH cord-282610-zim7nond 564 21 microbe microbe NN cord-282610-zim7nond 564 22 and and CC cord-282610-zim7nond 564 23 host host NN cord-282610-zim7nond 564 24 - - HYPH cord-282610-zim7nond 564 25 microbe microbe NN cord-282610-zim7nond 564 26 interactions interaction NNS cord-282610-zim7nond 564 27 drive drive VBP cord-282610-zim7nond 564 28 microbiome microbiome NN cord-282610-zim7nond 564 29 dysbiosis dysbiosis NN cord-282610-zim7nond 564 30 and and CC cord-282610-zim7nond 564 31 inflammatory inflammatory JJ cord-282610-zim7nond 564 32 processes process NNS cord-282610-zim7nond 565 1 The the DT cord-282610-zim7nond 565 2 human human JJ cord-282610-zim7nond 565 3 microbiome microbiome NN cord-282610-zim7nond 565 4 project project NN cord-282610-zim7nond 565 5 Does do VBZ cord-282610-zim7nond 565 6 blood blood NN cord-282610-zim7nond 565 7 of of IN cord-282610-zim7nond 565 8 healthy healthy JJ cord-282610-zim7nond 565 9 subjects subject NNS cord-282610-zim7nond 565 10 contain contain VBP cord-282610-zim7nond 565 11 bacterial bacterial JJ cord-282610-zim7nond 565 12 ribosomal ribosomal JJ cord-282610-zim7nond 565 13 DNA dna NN cord-282610-zim7nond 565 14 ? ? . cord-282610-zim7nond 566 1 Research research NN cord-282610-zim7nond 566 2 on on IN cord-282610-zim7nond 566 3 the the DT cord-282610-zim7nond 566 4 human human JJ cord-282610-zim7nond 566 5 virome virome NN cord-282610-zim7nond 566 6 : : : cord-282610-zim7nond 567 1 where where WRB cord-282610-zim7nond 567 2 are be VBP cord-282610-zim7nond 567 3 we -PRON- PRP cord-282610-zim7nond 567 4 and and CC cord-282610-zim7nond 567 5 what what WP cord-282610-zim7nond 567 6 is be VBZ cord-282610-zim7nond 567 7 next next JJ cord-282610-zim7nond 567 8 First first JJ cord-282610-zim7nond 567 9 insights insight NNS cord-282610-zim7nond 567 10 into into IN cord-282610-zim7nond 567 11 the the DT cord-282610-zim7nond 567 12 diverse diverse JJ cord-282610-zim7nond 567 13 human human JJ cord-282610-zim7nond 567 14 archaeome archaeome NN cord-282610-zim7nond 567 15 : : : cord-282610-zim7nond 567 16 specific specific JJ cord-282610-zim7nond 567 17 detection detection NN cord-282610-zim7nond 567 18 of of IN cord-282610-zim7nond 567 19 archaea archaea NNS cord-282610-zim7nond 567 20 in in IN cord-282610-zim7nond 567 21 the the DT cord-282610-zim7nond 567 22 gastrointestinal gastrointestinal JJ cord-282610-zim7nond 567 23 tract tract NN cord-282610-zim7nond 567 24 , , , cord-282610-zim7nond 567 25 lung lung NN cord-282610-zim7nond 567 26 , , , cord-282610-zim7nond 567 27 and and CC cord-282610-zim7nond 567 28 nose nose NN cord-282610-zim7nond 567 29 and and CC cord-282610-zim7nond 567 30 on on IN cord-282610-zim7nond 567 31 skin skin NN cord-282610-zim7nond 567 32 Viral viral JJ cord-282610-zim7nond 567 33 immunity immunity NN cord-282610-zim7nond 567 34 . . . cord-282610-zim7nond 568 1 transkingdom transkingdom NNP cord-282610-zim7nond 568 2 control control NN cord-282610-zim7nond 568 3 of of IN cord-282610-zim7nond 568 4 viral viral JJ cord-282610-zim7nond 568 5 infection infection NN cord-282610-zim7nond 568 6 and and CC cord-282610-zim7nond 568 7 immunity immunity NN cord-282610-zim7nond 568 8 in in IN cord-282610-zim7nond 568 9 the the DT cord-282610-zim7nond 568 10 mammalian mammalian JJ cord-282610-zim7nond 568 11 intestine intestine NN cord-282610-zim7nond 569 1 The the DT cord-282610-zim7nond 569 2 human human JJ cord-282610-zim7nond 569 3 superorganism superorganism NN cord-282610-zim7nond 569 4 -of -of ADD cord-282610-zim7nond 570 1 microbes microbe NNS cord-282610-zim7nond 570 2 and and CC cord-282610-zim7nond 570 3 men man NNS cord-282610-zim7nond 571 1 An an DT cord-282610-zim7nond 571 2 integrated integrated JJ cord-282610-zim7nond 571 3 catalog catalog NN cord-282610-zim7nond 571 4 of of IN cord-282610-zim7nond 571 5 reference reference NN cord-282610-zim7nond 571 6 genes gene NNS cord-282610-zim7nond 571 7 in in IN cord-282610-zim7nond 571 8 the the DT cord-282610-zim7nond 571 9 human human JJ cord-282610-zim7nond 571 10 gut gut NN cord-282610-zim7nond 571 11 microbiome microbiome NN cord-282610-zim7nond 572 1 The the DT cord-282610-zim7nond 572 2 lung lung NN cord-282610-zim7nond 572 3 microbiome microbiome NN cord-282610-zim7nond 572 4 , , , cord-282610-zim7nond 572 5 immunity immunity NN cord-282610-zim7nond 572 6 , , , cord-282610-zim7nond 572 7 and and CC cord-282610-zim7nond 572 8 the the DT cord-282610-zim7nond 572 9 pathogenesis pathogenesis NN cord-282610-zim7nond 572 10 of of IN cord-282610-zim7nond 572 11 chronic chronic JJ cord-282610-zim7nond 572 12 lung lung NN cord-282610-zim7nond 572 13 disease disease NN cord-282610-zim7nond 573 1 The the DT cord-282610-zim7nond 573 2 placenta placenta NN cord-282610-zim7nond 573 3 harbors harbor VBZ cord-282610-zim7nond 573 4 a a DT cord-282610-zim7nond 573 5 unique unique JJ cord-282610-zim7nond 573 6 microbiome microbiome NN cord-282610-zim7nond 573 7 Immunological immunological JJ cord-282610-zim7nond 573 8 tolerance tolerance NN cord-282610-zim7nond 573 9 , , , cord-282610-zim7nond 573 10 pregnancy pregnancy NN cord-282610-zim7nond 573 11 , , , cord-282610-zim7nond 573 12 and and CC cord-282610-zim7nond 573 13 preeclampsia preeclampsia NN cord-282610-zim7nond 573 14 : : : cord-282610-zim7nond 573 15 the the DT cord-282610-zim7nond 573 16 roles role NNS cord-282610-zim7nond 573 17 of of IN cord-282610-zim7nond 573 18 semen semen NN cord-282610-zim7nond 573 19 microbes microbe NNS cord-282610-zim7nond 573 20 and and CC cord-282610-zim7nond 573 21 the the DT cord-282610-zim7nond 573 22 father father NN cord-282610-zim7nond 573 23 Culturing culture VBG cord-282610-zim7nond 573 24 of of IN cord-282610-zim7nond 573 25 female female JJ cord-282610-zim7nond 573 26 bladder bladder NN cord-282610-zim7nond 573 27 bacteria bacteria NNS cord-282610-zim7nond 573 28 reveals reveal VBZ cord-282610-zim7nond 573 29 an an DT cord-282610-zim7nond 573 30 interconnected interconnected JJ cord-282610-zim7nond 573 31 urogenital urogenital JJ cord-282610-zim7nond 573 32 microbiota microbiota NN cord-282610-zim7nond 574 1 The the DT cord-282610-zim7nond 574 2 microbiota microbiota NN cord-282610-zim7nond 574 3 continuum continuum NN cord-282610-zim7nond 574 4 along along IN cord-282610-zim7nond 574 5 the the DT cord-282610-zim7nond 574 6 female female JJ cord-282610-zim7nond 574 7 reproductive reproductive JJ cord-282610-zim7nond 574 8 tract tract NN cord-282610-zim7nond 574 9 and and CC cord-282610-zim7nond 574 10 its -PRON- PRP$ cord-282610-zim7nond 574 11 relation relation NN cord-282610-zim7nond 574 12 to to IN cord-282610-zim7nond 574 13 uterine uterine NN cord-282610-zim7nond 574 14 - - HYPH cord-282610-zim7nond 574 15 related relate VBN cord-282610-zim7nond 574 16 diseases disease NNS cord-282610-zim7nond 574 17 Implants implant NNS cord-282610-zim7nond 574 18 induce induce VBP cord-282610-zim7nond 574 19 a a DT cord-282610-zim7nond 574 20 new new JJ cord-282610-zim7nond 574 21 niche niche NN cord-282610-zim7nond 574 22 for for IN cord-282610-zim7nond 574 23 microbiomes microbiome NNS cord-282610-zim7nond 575 1 The the DT cord-282610-zim7nond 575 2 characterization characterization NN cord-282610-zim7nond 575 3 of of IN cord-282610-zim7nond 575 4 novel novel JJ cord-282610-zim7nond 575 5 tissue tissue NN cord-282610-zim7nond 575 6 microbiota microbiota NN cord-282610-zim7nond 575 7 using use VBG cord-282610-zim7nond 575 8 an an DT cord-282610-zim7nond 575 9 optimized optimized JJ cord-282610-zim7nond 575 10 16s 16s NNPS cord-282610-zim7nond 575 11 metagenomic metagenomic NNP cord-282610-zim7nond 575 12 sequencing sequencing NNP cord-282610-zim7nond 575 13 pipeline pipeline NN cord-282610-zim7nond 575 14 Comprehensive comprehensive JJ cord-282610-zim7nond 575 15 detection detection NN cord-282610-zim7nond 575 16 and and CC cord-282610-zim7nond 575 17 identification identification NN cord-282610-zim7nond 575 18 of of IN cord-282610-zim7nond 575 19 bacterial bacterial JJ cord-282610-zim7nond 575 20 DNA dna NN cord-282610-zim7nond 575 21 in in IN cord-282610-zim7nond 575 22 the the DT cord-282610-zim7nond 575 23 blood blood NN cord-282610-zim7nond 575 24 of of IN cord-282610-zim7nond 575 25 patients patient NNS cord-282610-zim7nond 575 26 with with IN cord-282610-zim7nond 575 27 sepsis sepsis NN cord-282610-zim7nond 575 28 and and CC cord-282610-zim7nond 575 29 healthy healthy JJ cord-282610-zim7nond 575 30 volunteers volunteer NNS cord-282610-zim7nond 575 31 using use VBG cord-282610-zim7nond 575 32 next next JJ cord-282610-zim7nond 575 33 - - HYPH cord-282610-zim7nond 575 34 generation generation NN cord-282610-zim7nond 575 35 sequencing sequencing NN cord-282610-zim7nond 575 36 method method NN cord-282610-zim7nond 575 37 -the -the ADD cord-282610-zim7nond 575 38 observation observation NN cord-282610-zim7nond 575 39 of of IN cord-282610-zim7nond 575 40 DNAemia DNAemia NNP cord-282610-zim7nond 576 1 The the DT cord-282610-zim7nond 576 2 dormant dormant JJ cord-282610-zim7nond 576 3 blood blood NN cord-282610-zim7nond 576 4 microbiome microbiome NN cord-282610-zim7nond 576 5 in in IN cord-282610-zim7nond 576 6 chronic chronic JJ cord-282610-zim7nond 576 7 , , , cord-282610-zim7nond 576 8 inflammatory inflammatory JJ cord-282610-zim7nond 576 9 diseases disease NNS cord-282610-zim7nond 576 10 Comprehensive comprehensive JJ cord-282610-zim7nond 576 11 description description NN cord-282610-zim7nond 576 12 of of IN cord-282610-zim7nond 576 13 blood blood NN cord-282610-zim7nond 576 14 microbiome microbiome NN cord-282610-zim7nond 576 15 from from IN cord-282610-zim7nond 576 16 healthy healthy JJ cord-282610-zim7nond 576 17 donors donor NNS cord-282610-zim7nond 576 18 assessed assess VBN cord-282610-zim7nond 576 19 by by IN cord-282610-zim7nond 576 20 16S 16S NNP cord-282610-zim7nond 576 21 targeted target VBN cord-282610-zim7nond 576 22 metagenomic metagenomic NN cord-282610-zim7nond 576 23 sequencing sequence VBG cord-282610-zim7nond 576 24 The the DT cord-282610-zim7nond 576 25 blood blood NN cord-282610-zim7nond 576 26 DNA dna NN cord-282610-zim7nond 576 27 virome virome NN cord-282610-zim7nond 576 28 in in IN cord-282610-zim7nond 576 29 8,000 8,000 CD cord-282610-zim7nond 576 30 humans human NNS cord-282610-zim7nond 576 31 PLoS PLoS NNP cord-282610-zim7nond 576 32 Pathog Pathog NNP cord-282610-zim7nond 576 33 Cultural cultural JJ cord-282610-zim7nond 576 34 isolation isolation NN cord-282610-zim7nond 576 35 and and CC cord-282610-zim7nond 576 36 characteristics characteristic NNS cord-282610-zim7nond 576 37 of of IN cord-282610-zim7nond 576 38 the the DT cord-282610-zim7nond 576 39 blood blood NN cord-282610-zim7nond 576 40 microbiome microbiome NN cord-282610-zim7nond 576 41 of of IN cord-282610-zim7nond 576 42 healthy healthy JJ cord-282610-zim7nond 576 43 individuals individual NNS cord-282610-zim7nond 576 44 Multi multi JJ cord-282610-zim7nond 576 45 - - HYPH cord-282610-zim7nond 576 46 Method method NN cord-282610-zim7nond 576 47 characterisation characterisation NN cord-282610-zim7nond 576 48 of of IN cord-282610-zim7nond 576 49 the the DT cord-282610-zim7nond 576 50 human human JJ cord-282610-zim7nond 576 51 circulating circulate VBG cord-282610-zim7nond 576 52 microbiome microbiome NN cord-282610-zim7nond 576 53 Microbial microbial JJ cord-282610-zim7nond 576 54 changes change NNS cord-282610-zim7nond 576 55 during during IN cord-282610-zim7nond 576 56 pregnancy pregnancy NN cord-282610-zim7nond 576 57 , , , cord-282610-zim7nond 576 58 birth birth NN cord-282610-zim7nond 576 59 , , , cord-282610-zim7nond 576 60 and and CC cord-282610-zim7nond 576 61 infancy infancy NN cord-282610-zim7nond 577 1 The the DT cord-282610-zim7nond 577 2 human human JJ cord-282610-zim7nond 577 3 milk milk NN cord-282610-zim7nond 577 4 microbiome microbiome NN cord-282610-zim7nond 577 5 and and CC cord-282610-zim7nond 577 6 factors factor NNS cord-282610-zim7nond 577 7 influencing influence VBG cord-282610-zim7nond 577 8 its -PRON- PRP$ cord-282610-zim7nond 577 9 composition composition NN cord-282610-zim7nond 577 10 and and CC cord-282610-zim7nond 577 11 activity activity NN cord-282610-zim7nond 577 12 Variation variation NN cord-282610-zim7nond 577 13 in in IN cord-282610-zim7nond 577 14 the the DT cord-282610-zim7nond 577 15 human human JJ cord-282610-zim7nond 577 16 immune immune NN cord-282610-zim7nond 577 17 system system NN cord-282610-zim7nond 577 18 is be VBZ cord-282610-zim7nond 577 19 largely largely RB cord-282610-zim7nond 577 20 driven drive VBN cord-282610-zim7nond 577 21 by by IN cord-282610-zim7nond 577 22 non non JJ cord-282610-zim7nond 577 23 - - JJ cord-282610-zim7nond 577 24 heritable heritable JJ cord-282610-zim7nond 577 25 influences influence NNS cord-282610-zim7nond 577 26 Structural structural JJ cord-282610-zim7nond 577 27 and and CC cord-282610-zim7nond 577 28 functional functional JJ cord-282610-zim7nond 577 29 features feature NNS cord-282610-zim7nond 577 30 of of IN cord-282610-zim7nond 577 31 central central JJ cord-282610-zim7nond 577 32 nervous nervous JJ cord-282610-zim7nond 577 33 system system NN cord-282610-zim7nond 577 34 lymphatic lymphatic NN cord-282610-zim7nond 577 35 vessels vessel NNS cord-282610-zim7nond 577 36 Structure structure NN cord-282610-zim7nond 577 37 and and CC cord-282610-zim7nond 577 38 distribution distribution NN cord-282610-zim7nond 577 39 of of IN cord-282610-zim7nond 577 40 an an DT cord-282610-zim7nond 577 41 unrecognized unrecognized JJ cord-282610-zim7nond 577 42 interstitium interstitium NN cord-282610-zim7nond 577 43 in in IN cord-282610-zim7nond 577 44 human human JJ cord-282610-zim7nond 577 45 tissues tissue NNS cord-282610-zim7nond 578 1 A a DT cord-282610-zim7nond 578 2 dural dural JJ cord-282610-zim7nond 578 3 lymphatic lymphatic NN cord-282610-zim7nond 578 4 vascular vascular JJ cord-282610-zim7nond 578 5 system system NN cord-282610-zim7nond 578 6 that that WDT cord-282610-zim7nond 578 7 drains drain VBZ cord-282610-zim7nond 578 8 brain brain NN cord-282610-zim7nond 578 9 interstitial interstitial JJ cord-282610-zim7nond 578 10 fluid fluid NN cord-282610-zim7nond 578 11 and and CC cord-282610-zim7nond 578 12 macromolecules macromolecule NNS cord-282610-zim7nond 578 13 Functional functional JJ cord-282610-zim7nond 578 14 aspects aspect NNS cord-282610-zim7nond 578 15 of of IN cord-282610-zim7nond 578 16 meningeal meningeal JJ cord-282610-zim7nond 578 17 lymphatics lymphatic NNS cord-282610-zim7nond 578 18 in in IN cord-282610-zim7nond 578 19 ageing age VBG cord-282610-zim7nond 578 20 and and CC cord-282610-zim7nond 578 21 Alzheimer Alzheimer NNP cord-282610-zim7nond 578 22 's 's POS cord-282610-zim7nond 578 23 disease disease NN cord-282610-zim7nond 578 24 Bacteriophages bacteriophage NNS cord-282610-zim7nond 578 25 of of IN cord-282610-zim7nond 578 26 the the DT cord-282610-zim7nond 578 27 urinary urinary JJ cord-282610-zim7nond 578 28 microbiome microbiome NN cord-282610-zim7nond 579 1 NCBI NCBI NNP cord-282610-zim7nond 579 2 prokaryotic prokaryotic JJ cord-282610-zim7nond 579 3 genome genome NN cord-282610-zim7nond 579 4 annotation annotation NN cord-282610-zim7nond 579 5 pipeline pipeline NN cord-282610-zim7nond 580 1 Archaea Archaea NNS cord-282610-zim7nond 580 2 are be VBP cord-282610-zim7nond 580 3 interactive interactive JJ cord-282610-zim7nond 580 4 components component NNS cord-282610-zim7nond 580 5 of of IN cord-282610-zim7nond 580 6 complex complex JJ cord-282610-zim7nond 580 7 microbiomes microbiome NNS cord-282610-zim7nond 580 8 Measuring measure VBG cord-282610-zim7nond 580 9 the the DT cord-282610-zim7nond 580 10 archaeome archaeome NN cord-282610-zim7nond 580 11 : : : cord-282610-zim7nond 580 12 detection detection NN cord-282610-zim7nond 580 13 and and CC cord-282610-zim7nond 580 14 quantification quantification NN cord-282610-zim7nond 580 15 of of IN cord-282610-zim7nond 580 16 archaea archaea JJ cord-282610-zim7nond 580 17 signatures signature NNS cord-282610-zim7nond 580 18 in in IN cord-282610-zim7nond 580 19 the the DT cord-282610-zim7nond 580 20 human human JJ cord-282610-zim7nond 580 21 body body NN cord-282610-zim7nond 580 22 Uncovering uncover VBG cord-282610-zim7nond 580 23 Earth Earth NNP cord-282610-zim7nond 580 24 's 's POS cord-282610-zim7nond 580 25 virome virome NN cord-282610-zim7nond 580 26 Bacteriophage Bacteriophage NNP cord-282610-zim7nond 580 27 transcytosis transcytosis NNP cord-282610-zim7nond 580 28 provides provide VBZ cord-282610-zim7nond 580 29 a a DT cord-282610-zim7nond 580 30 mechanism mechanism NN cord-282610-zim7nond 580 31 to to TO cord-282610-zim7nond 580 32 cross cross VB cord-282610-zim7nond 580 33 epithelial epithelial JJ cord-282610-zim7nond 580 34 cell cell NN cord-282610-zim7nond 580 35 layers layer NNS cord-282610-zim7nond 580 36 Does do VBZ cord-282610-zim7nond 580 37 the the DT cord-282610-zim7nond 580 38 microbiome microbiome NN cord-282610-zim7nond 580 39 and and CC cord-282610-zim7nond 580 40 virome virome NNP cord-282610-zim7nond 580 41 contribute contribute VBP cord-282610-zim7nond 580 42 to to IN cord-282610-zim7nond 580 43 myalgic myalgic JJ cord-282610-zim7nond 580 44 encephalomyelitis encephalomyelitis NN cord-282610-zim7nond 580 45 / / SYM cord-282610-zim7nond 580 46 chronic chronic JJ cord-282610-zim7nond 580 47 fatigue fatigue NN cord-282610-zim7nond 580 48 syndrome syndrome NN cord-282610-zim7nond 580 49 ? ? . cord-282610-zim7nond 581 1 IMG IMG NNP cord-282610-zim7nond 581 2 / / SYM cord-282610-zim7nond 581 3 VR VR NNP cord-282610-zim7nond 581 4 : : : cord-282610-zim7nond 581 5 a a DT cord-282610-zim7nond 581 6 database database NN cord-282610-zim7nond 581 7 of of IN cord-282610-zim7nond 581 8 cultured cultured JJ cord-282610-zim7nond 581 9 and and CC cord-282610-zim7nond 581 10 uncultured uncultured JJ cord-282610-zim7nond 581 11 DNA dna NN cord-282610-zim7nond 581 12 Viruses virus NNS cord-282610-zim7nond 581 13 and and CC cord-282610-zim7nond 581 14 retroviruses retrovirus NNS cord-282610-zim7nond 581 15 IMG IMG NNP cord-282610-zim7nond 581 16 / / SYM cord-282610-zim7nond 581 17 VR VR NNP cord-282610-zim7nond 581 18 Database Database NNP cord-282610-zim7nond 581 19 Triples Triples NNP cord-282610-zim7nond 581 20 in in IN cord-282610-zim7nond 581 21 Size Size NNP cord-282610-zim7nond 581 22 Persistent Persistent NNP cord-282610-zim7nond 581 23 elevated elevated JJ cord-282610-zim7nond 581 24 expression expression NN cord-282610-zim7nond 581 25 of of IN cord-282610-zim7nond 581 26 cytokine cytokine JJ cord-282610-zim7nond 581 27 transcripts transcript NNS cord-282610-zim7nond 581 28 in in IN cord-282610-zim7nond 581 29 ganglia ganglion NNS cord-282610-zim7nond 581 30 latently latently RB cord-282610-zim7nond 581 31 infected infect VBN cord-282610-zim7nond 581 32 with with IN cord-282610-zim7nond 581 33 herpes herpes NN cord-282610-zim7nond 581 34 simplex simplex NNP cord-282610-zim7nond 581 35 virus virus NN cord-282610-zim7nond 581 36 in in IN cord-282610-zim7nond 581 37 the the DT cord-282610-zim7nond 581 38 absence absence NN cord-282610-zim7nond 581 39 of of IN cord-282610-zim7nond 581 40 ganglionic ganglionic FW cord-282610-zim7nond 581 41 replication replication NN cord-282610-zim7nond 581 42 or or CC cord-282610-zim7nond 581 43 reactivation reactivation NN cord-282610-zim7nond 581 44 Function function NN cord-282610-zim7nond 581 45 and and CC cord-282610-zim7nond 581 46 functional functional JJ cord-282610-zim7nond 581 47 redundancy redundancy NN cord-282610-zim7nond 581 48 in in IN cord-282610-zim7nond 581 49 microbial microbial JJ cord-282610-zim7nond 581 50 systems system NNS cord-282610-zim7nond 581 51 Functional functional JJ cord-282610-zim7nond 581 52 redundancy redundancy NN cord-282610-zim7nond 581 53 of of IN cord-282610-zim7nond 581 54 soil soil NN cord-282610-zim7nond 581 55 microbiota microbiota NN cord-282610-zim7nond 581 56 -does -doe VBZ cord-282610-zim7nond 581 57 more more RBR cord-282610-zim7nond 581 58 always always RB cord-282610-zim7nond 581 59 mean mean VB cord-282610-zim7nond 581 60 better well JJR cord-282610-zim7nond 581 61 ? ? . cord-282610-zim7nond 582 1 Metabolomics metabolomic NNS cord-282610-zim7nond 582 2 analysis analysis NN cord-282610-zim7nond 582 3 reveals reveal VBZ cord-282610-zim7nond 582 4 large large JJ cord-282610-zim7nond 582 5 effects effect NNS cord-282610-zim7nond 582 6 of of IN cord-282610-zim7nond 582 7 gut gut NN cord-282610-zim7nond 582 8 microflora microflora NN cord-282610-zim7nond 582 9 on on IN cord-282610-zim7nond 582 10 mammalian mammalian JJ cord-282610-zim7nond 582 11 blood blood NN cord-282610-zim7nond 582 12 metabolites metabolite NNS cord-282610-zim7nond 582 13 Natural natural JJ cord-282610-zim7nond 582 14 killer killer NN cord-282610-zim7nond 582 15 cells cell NNS cord-282610-zim7nond 582 16 in in IN cord-282610-zim7nond 582 17 patients patient NNS cord-282610-zim7nond 582 18 with with IN cord-282610-zim7nond 582 19 severe severe JJ cord-282610-zim7nond 582 20 chronic chronic JJ cord-282610-zim7nond 582 21 fatigue fatigue NN cord-282610-zim7nond 582 22 syndrome syndrome NN cord-282610-zim7nond 582 23 Gut Gut NNP cord-282610-zim7nond 582 24 microbiomemediated microbiomemediate VBN cord-282610-zim7nond 583 1 bile bile NN cord-282610-zim7nond 583 2 acid acid NN cord-282610-zim7nond 583 3 metabolism metabolism NN cord-282610-zim7nond 583 4 regulates regulate VBZ cord-282610-zim7nond 583 5 liver liver NN cord-282610-zim7nond 583 6 cancer cancer NN cord-282610-zim7nond 583 7 via via IN cord-282610-zim7nond 583 8 NKT NKT NNP cord-282610-zim7nond 583 9 cells cell NNS cord-282610-zim7nond 584 1 Lactic lactic JJ cord-282610-zim7nond 584 2 acid acid NN cord-282610-zim7nond 584 3 bacteria bacteria NNS cord-282610-zim7nond 584 4 from from IN cord-282610-zim7nond 584 5 kefir kefir NN cord-282610-zim7nond 584 6 increase increase NN cord-282610-zim7nond 584 7 cytotoxicity cytotoxicity NN cord-282610-zim7nond 584 8 of of IN cord-282610-zim7nond 584 9 natural natural JJ cord-282610-zim7nond 584 10 killer killer NN cord-282610-zim7nond 584 11 cells cell NNS cord-282610-zim7nond 584 12 to to IN cord-282610-zim7nond 585 1 tumor tumor NN cord-282610-zim7nond 585 2 cells cell NNS cord-282610-zim7nond 585 3 Type type NN cord-282610-zim7nond 586 1 I -PRON- PRP cord-282610-zim7nond 586 2 interferons interferon NNS cord-282610-zim7nond 586 3 and and CC cord-282610-zim7nond 586 4 microbial microbial JJ cord-282610-zim7nond 586 5 metabolites metabolite NNS cord-282610-zim7nond 586 6 of of IN cord-282610-zim7nond 586 7 tryptophan tryptophan NN cord-282610-zim7nond 586 8 modulate modulate VBP cord-282610-zim7nond 586 9 astrocyte astrocyte JJ cord-282610-zim7nond 586 10 activity activity NN cord-282610-zim7nond 586 11 and and CC cord-282610-zim7nond 586 12 central central JJ cord-282610-zim7nond 586 13 nervous nervous JJ cord-282610-zim7nond 586 14 system system NN cord-282610-zim7nond 586 15 inflammation inflammation NN cord-282610-zim7nond 586 16 via via IN cord-282610-zim7nond 586 17 the the DT cord-282610-zim7nond 586 18 aryl aryl NN cord-282610-zim7nond 586 19 hydrocarbon hydrocarbon NN cord-282610-zim7nond 586 20 receptor receptor NN cord-282610-zim7nond 586 21 Symptoms symptom NNS cord-282610-zim7nond 586 22 of of IN cord-282610-zim7nond 586 23 autonomic autonomic JJ cord-282610-zim7nond 586 24 dysfunction dysfunction NN cord-282610-zim7nond 586 25 in in IN cord-282610-zim7nond 586 26 chronic chronic JJ cord-282610-zim7nond 586 27 fatigue fatigue NN cord-282610-zim7nond 586 28 syndrome syndrome NN cord-282610-zim7nond 586 29 Circadian circadian JJ cord-282610-zim7nond 586 30 rhythm rhythm NN cord-282610-zim7nond 586 31 abnormalities abnormality NNS cord-282610-zim7nond 586 32 and and CC cord-282610-zim7nond 586 33 autonomic autonomic JJ cord-282610-zim7nond 586 34 dysfunction dysfunction NN cord-282610-zim7nond 586 35 in in IN cord-282610-zim7nond 586 36 patients patient NNS cord-282610-zim7nond 586 37 with with IN cord-282610-zim7nond 586 38 Chronic Chronic NNP cord-282610-zim7nond 586 39 Fatigue Fatigue NNP cord-282610-zim7nond 586 40 Syndrome Syndrome NNP cord-282610-zim7nond 586 41 / / SYM cord-282610-zim7nond 586 42 Myalgic Myalgic NNP cord-282610-zim7nond 586 43 Encephalomyelitis Encephalomyelitis NNP cord-282610-zim7nond 586 44 Olfactory Olfactory NNP cord-282610-zim7nond 586 45 receptor receptor NN cord-282610-zim7nond 586 46 responding respond VBG cord-282610-zim7nond 586 47 to to TO cord-282610-zim7nond 586 48 gut gut VB cord-282610-zim7nond 586 49 microbiota microbiota NN cord-282610-zim7nond 586 50 - - HYPH cord-282610-zim7nond 586 51 derived derive VBN cord-282610-zim7nond 586 52 signals signal NNS cord-282610-zim7nond 586 53 plays play VBZ cord-282610-zim7nond 586 54 a a DT cord-282610-zim7nond 586 55 role role NN cord-282610-zim7nond 586 56 in in IN cord-282610-zim7nond 586 57 renin renin NN cord-282610-zim7nond 586 58 secretion secretion NN cord-282610-zim7nond 586 59 and and CC cord-282610-zim7nond 586 60 blood blood NN cord-282610-zim7nond 586 61 pressure pressure NN cord-282610-zim7nond 586 62 regulation regulation NN cord-282610-zim7nond 586 63 Infection infection NN cord-282610-zim7nond 586 64 of of IN cord-282610-zim7nond 586 65 NK NK NNP cord-282610-zim7nond 586 66 cells cell NNS cord-282610-zim7nond 586 67 modulates modulate VBZ cord-282610-zim7nond 586 68 the the DT cord-282610-zim7nond 586 69 expression expression NN cord-282610-zim7nond 586 70 of of IN cord-282610-zim7nond 586 71 miRNAs miRNAs NNP cord-282610-zim7nond 586 72 and and CC cord-282610-zim7nond 586 73 transcription transcription NN cord-282610-zim7nond 586 74 factors factor NNS cord-282610-zim7nond 586 75 potentially potentially RB cord-282610-zim7nond 586 76 associated associate VBN cord-282610-zim7nond 586 77 to to IN cord-282610-zim7nond 586 78 impaired impaired JJ cord-282610-zim7nond 586 79 NK NK NNP cord-282610-zim7nond 586 80 activity activity NN cord-282610-zim7nond 586 81 . . . cord-282610-zim7nond 587 1 Front Front NNP cord-282610-zim7nond 587 2 Microbiol Microbiol NNP cord-282610-zim7nond 587 3 Reprogramming reprogramming NN cord-282610-zim7nond 587 4 adult adult NN cord-282610-zim7nond 587 5 Schwann Schwann NNP cord-282610-zim7nond 587 6 cells cell NNS cord-282610-zim7nond 587 7 to to TO cord-282610-zim7nond 587 8 stem stem VB cord-282610-zim7nond 587 9 cell cell NN cord-282610-zim7nond 587 10 - - HYPH cord-282610-zim7nond 587 11 like like JJ cord-282610-zim7nond 587 12 cells cell NNS cord-282610-zim7nond 587 13 by by IN cord-282610-zim7nond 587 14 leprosy leprosy NN cord-282610-zim7nond 587 15 bacilli bacilli NN cord-282610-zim7nond 587 16 promotes promote VBZ cord-282610-zim7nond 587 17 dissemination dissemination NN cord-282610-zim7nond 587 18 of of IN cord-282610-zim7nond 587 19 infection infection NN cord-282610-zim7nond 588 1 The the DT cord-282610-zim7nond 588 2 extracellular extracellular JJ cord-282610-zim7nond 588 3 domain domain NN cord-282610-zim7nond 588 4 of of IN cord-282610-zim7nond 588 5 Staphylococcus Staphylococcus NNP cord-282610-zim7nond 588 6 aureus aureus NN cord-282610-zim7nond 588 7 LtaS LtaS NNP cord-282610-zim7nond 588 8 binds bind VBZ cord-282610-zim7nond 588 9 insulin insulin NN cord-282610-zim7nond 588 10 and and CC cord-282610-zim7nond 588 11 induces induce VBZ cord-282610-zim7nond 588 12 insulin insulin NN cord-282610-zim7nond 588 13 resistance resistance NN cord-282610-zim7nond 588 14 during during IN cord-282610-zim7nond 588 15 infection infection NN cord-282610-zim7nond 588 16 Quorum Quorum NNP cord-282610-zim7nond 588 17 sensing sensing NN cord-282610-zim7nond 588 18 and and CC cord-282610-zim7nond 588 19 microbial microbial JJ cord-282610-zim7nond 588 20 biofilms biofilm NNS cord-282610-zim7nond 588 21 Speciesindependent Speciesindependent NNP cord-282610-zim7nond 588 22 attraction attraction NN cord-282610-zim7nond 588 23 to to TO cord-282610-zim7nond 588 24 biofilms biofilms VB cord-282610-zim7nond 588 25 through through IN cord-282610-zim7nond 588 26 electrical electrical JJ cord-282610-zim7nond 588 27 signaling signaling NN cord-282610-zim7nond 588 28 I -PRON- PRP cord-282610-zim7nond 588 29 will will MD cord-282610-zim7nond 588 30 survive survive VB cord-282610-zim7nond 588 31 " " '' cord-282610-zim7nond 588 32 : : : cord-282610-zim7nond 588 33 a a DT cord-282610-zim7nond 588 34 tale tale NN cord-282610-zim7nond 588 35 of of IN cord-282610-zim7nond 588 36 bacteriophage bacteriophage NN cord-282610-zim7nond 588 37 - - HYPH cord-282610-zim7nond 588 38 bacteria bacteria NNS cord-282610-zim7nond 588 39 coevolution coevolution NN cord-282610-zim7nond 588 40 in in IN cord-282610-zim7nond 588 41 the the DT cord-282610-zim7nond 588 42 gut gut NN cord-282610-zim7nond 588 43 Enteric enteric JJ cord-282610-zim7nond 588 44 bacteria bacteria NNS cord-282610-zim7nond 588 45 promote promote VBP cord-282610-zim7nond 588 46 human human JJ cord-282610-zim7nond 588 47 and and CC cord-282610-zim7nond 588 48 mouse mouse NN cord-282610-zim7nond 588 49 norovirus norovirus NN cord-282610-zim7nond 588 50 infection infection NN cord-282610-zim7nond 588 51 of of IN cord-282610-zim7nond 588 52 B b NN cord-282610-zim7nond 588 53 cells cell NNS cord-282610-zim7nond 588 54 Defining define VBG cord-282610-zim7nond 588 55 dysbiosis dysbiosis NN cord-282610-zim7nond 588 56 and and CC cord-282610-zim7nond 588 57 its -PRON- PRP$ cord-282610-zim7nond 588 58 influence influence NN cord-282610-zim7nond 588 59 on on IN cord-282610-zim7nond 588 60 host host NN cord-282610-zim7nond 588 61 immunity immunity NN cord-282610-zim7nond 588 62 and and CC cord-282610-zim7nond 588 63 disease disease NN cord-282610-zim7nond 589 1 The the DT cord-282610-zim7nond 589 2 microbiome microbiome NN cord-282610-zim7nond 589 3 and and CC cord-282610-zim7nond 589 4 autoimmunity autoimmunity NN cord-282610-zim7nond 589 5 : : : cord-282610-zim7nond 589 6 a a DT cord-282610-zim7nond 589 7 paradigm paradigm NN cord-282610-zim7nond 589 8 from from IN cord-282610-zim7nond 589 9 the the DT cord-282610-zim7nond 589 10 gut gut NN cord-282610-zim7nond 589 11 - - HYPH cord-282610-zim7nond 589 12 liver liver NN cord-282610-zim7nond 589 13 axis axis NN cord-282610-zim7nond 589 14 Gut gut NN cord-282610-zim7nond 589 15 microbiota microbiota NN cord-282610-zim7nond 589 16 regulate regulate VB cord-282610-zim7nond 589 17 motor motor NN cord-282610-zim7nond 589 18 deficits deficit NNS cord-282610-zim7nond 589 19 and and CC cord-282610-zim7nond 589 20 neuroinflammation neuroinflammation NN cord-282610-zim7nond 589 21 in in IN cord-282610-zim7nond 589 22 a a DT cord-282610-zim7nond 589 23 model model NN cord-282610-zim7nond 589 24 of of IN cord-282610-zim7nond 589 25 Parkinson Parkinson NNP cord-282610-zim7nond 589 26 's 's POS cord-282610-zim7nond 589 27 Disease Disease NNP cord-282610-zim7nond 589 28 Microbiome Microbiome NNP cord-282610-zim7nond 589 29 - - HYPH cord-282610-zim7nond 589 30 driven drive VBN cord-282610-zim7nond 589 31 carcinogenesis carcinogenesis NN cord-282610-zim7nond 589 32 in in IN cord-282610-zim7nond 589 33 colorectal colorectal JJ cord-282610-zim7nond 589 34 cancer cancer NN cord-282610-zim7nond 589 35 : : : cord-282610-zim7nond 589 36 models model NNS cord-282610-zim7nond 589 37 and and CC cord-282610-zim7nond 589 38 mechanisms mechanism NNS cord-282610-zim7nond 590 1 The the DT cord-282610-zim7nond 590 2 microbiota microbiota NN cord-282610-zim7nond 590 3 of of IN cord-282610-zim7nond 590 4 breast breast NN cord-282610-zim7nond 590 5 tissue tissue NN cord-282610-zim7nond 590 6 and and CC cord-282610-zim7nond 590 7 its -PRON- PRP$ cord-282610-zim7nond 590 8 association association NN cord-282610-zim7nond 590 9 with with IN cord-282610-zim7nond 590 10 breast breast NN cord-282610-zim7nond 590 11 cancer cancer NN cord-282610-zim7nond 590 12 Atopobium Atopobium NNP cord-282610-zim7nond 590 13 and and CC cord-282610-zim7nond 590 14 Fusobacterium Fusobacterium NNP cord-282610-zim7nond 590 15 as as IN cord-282610-zim7nond 590 16 novel novel JJ cord-282610-zim7nond 590 17 candidates candidate NNS cord-282610-zim7nond 590 18 for for IN cord-282610-zim7nond 590 19 sarcoidosis sarcoidosis NN cord-282610-zim7nond 590 20 - - HYPH cord-282610-zim7nond 590 21 associated associate VBN cord-282610-zim7nond 590 22 microbiota microbiota NN cord-282610-zim7nond 591 1 Intestinal intestinal JJ cord-282610-zim7nond 591 2 virome virome NN cord-282610-zim7nond 591 3 changes change NNS cord-282610-zim7nond 591 4 precede precede VBP cord-282610-zim7nond 591 5 autoimmunity autoimmunity NN cord-282610-zim7nond 591 6 in in IN cord-282610-zim7nond 591 7 type type NN cord-282610-zim7nond 591 8 I -PRON- PRP cord-282610-zim7nond 591 9 diabetes diabete VBZ cord-282610-zim7nond 591 10 - - HYPH cord-282610-zim7nond 591 11 susceptible susceptible JJ cord-282610-zim7nond 591 12 children child NNS cord-282610-zim7nond 591 13 Fecal fecal JJ cord-282610-zim7nond 591 14 metagenomic metagenomic JJ cord-282610-zim7nond 591 15 profiles profile NNS cord-282610-zim7nond 591 16 in in IN cord-282610-zim7nond 591 17 subgroups subgroup NNS cord-282610-zim7nond 591 18 of of IN cord-282610-zim7nond 591 19 patients patient NNS cord-282610-zim7nond 591 20 with with IN cord-282610-zim7nond 591 21 myalgic myalgic JJ cord-282610-zim7nond 591 22 encephalomyelitis encephalomyelitis NN cord-282610-zim7nond 591 23 / / SYM cord-282610-zim7nond 591 24 chronic chronic JJ cord-282610-zim7nond 591 25 fatigue fatigue NN cord-282610-zim7nond 591 26 syndrome syndrome NN cord-282610-zim7nond 591 27 Moving move VBG cord-282610-zim7nond 591 28 pictures picture NNS cord-282610-zim7nond 591 29 of of IN cord-282610-zim7nond 591 30 the the DT cord-282610-zim7nond 591 31 human human JJ cord-282610-zim7nond 591 32 microbiome microbiome NN cord-282610-zim7nond 591 33 High high JJ cord-282610-zim7nond 591 34 - - HYPH cord-282610-zim7nond 591 35 throughput throughput NN cord-282610-zim7nond 591 36 16S 16S NNP cord-282610-zim7nond 591 37 rRNA rrna NN cord-282610-zim7nond 591 38 gene gene NN cord-282610-zim7nond 591 39 sequencing sequencing NN cord-282610-zim7nond 591 40 reveals reveal VBZ cord-282610-zim7nond 591 41 alterations alteration NNS cord-282610-zim7nond 591 42 of of IN cord-282610-zim7nond 591 43 intestinal intestinal JJ cord-282610-zim7nond 591 44 microbiota microbiota NN cord-282610-zim7nond 591 45 in in IN cord-282610-zim7nond 591 46 myalgic myalgic JJ cord-282610-zim7nond 591 47 encephalomyelitis encephalomyelitis NN cord-282610-zim7nond 591 48 / / SYM cord-282610-zim7nond 591 49 chronic chronic JJ cord-282610-zim7nond 591 50 fatigue fatigue NN cord-282610-zim7nond 591 51 syndrome syndrome NN cord-282610-zim7nond 591 52 patients patient VBZ cord-282610-zim7nond 591 53 Transcriptome Transcriptome NNP cord-282610-zim7nond 591 54 analysis analysis NN cord-282610-zim7nond 591 55 in in IN cord-282610-zim7nond 591 56 whole whole JJ cord-282610-zim7nond 591 57 blood blood NN cord-282610-zim7nond 591 58 reveals reveal VBZ cord-282610-zim7nond 591 59 increased increase VBN cord-282610-zim7nond 591 60 microbial microbial JJ cord-282610-zim7nond 591 61 diversity diversity NN cord-282610-zim7nond 591 62 in in IN cord-282610-zim7nond 591 63 schizophrenia schizophrenia NNP cord-282610-zim7nond 591 64 Multiscale Multiscale NNP cord-282610-zim7nond 591 65 Analysis Analysis NNP cord-282610-zim7nond 591 66 of of IN cord-282610-zim7nond 591 67 independent independent JJ cord-282610-zim7nond 591 68 Alzheimer Alzheimer NNP cord-282610-zim7nond 591 69 's 's POS cord-282610-zim7nond 591 70 cohorts cohort NNS cord-282610-zim7nond 591 71 finds find VBZ cord-282610-zim7nond 591 72 disruption disruption NN cord-282610-zim7nond 591 73 of of IN cord-282610-zim7nond 591 74 molecular molecular JJ cord-282610-zim7nond 591 75 , , , cord-282610-zim7nond 591 76 genetic genetic JJ cord-282610-zim7nond 591 77 , , , cord-282610-zim7nond 591 78 and and CC cord-282610-zim7nond 591 79 clinical clinical JJ cord-282610-zim7nond 591 80 networks network NNS cord-282610-zim7nond 591 81 by by IN cord-282610-zim7nond 591 82 human human JJ cord-282610-zim7nond 591 83 herpesvirus herpesvirus NN cord-282610-zim7nond 591 84 Different different JJ cord-282610-zim7nond 591 85 brain brain NN cord-282610-zim7nond 591 86 regions region NNS cord-282610-zim7nond 591 87 are be VBP cord-282610-zim7nond 591 88 infected infect VBN cord-282610-zim7nond 591 89 with with IN cord-282610-zim7nond 591 90 fungi fungus NNS cord-282610-zim7nond 591 91 in in IN cord-282610-zim7nond 591 92 Alzheimer Alzheimer NNP cord-282610-zim7nond 591 93 's 's POS cord-282610-zim7nond 591 94 disease disease NN cord-282610-zim7nond 591 95 . . . cord-282610-zim7nond 592 1 Sci Sci NNP cord-282610-zim7nond 592 2 Rep Rep NNP cord-282610-zim7nond 592 3 Infection Infection NNP cord-282610-zim7nond 592 4 of of IN cord-282610-zim7nond 592 5 fungi fungus NNS cord-282610-zim7nond 592 6 and and CC cord-282610-zim7nond 592 7 bacteria bacteria NNS cord-282610-zim7nond 592 8 in in IN cord-282610-zim7nond 592 9 brain brain NN cord-282610-zim7nond 592 10 tissue tissue NN cord-282610-zim7nond 592 11 from from IN cord-282610-zim7nond 592 12 elderly elderly JJ cord-282610-zim7nond 592 13 persons person NNS cord-282610-zim7nond 592 14 and and CC cord-282610-zim7nond 592 15 patients patient NNS cord-282610-zim7nond 592 16 with with IN cord-282610-zim7nond 592 17 Alzheimer Alzheimer NNP cord-282610-zim7nond 592 18 's 's POS cord-282610-zim7nond 592 19 disease disease NN cord-282610-zim7nond 592 20 Brain Brain NNP cord-282610-zim7nond 592 21 microbial microbial JJ cord-282610-zim7nond 592 22 populations population NNS cord-282610-zim7nond 592 23 in in IN cord-282610-zim7nond 592 24 HIV HIV NNP cord-282610-zim7nond 592 25 / / SYM cord-282610-zim7nond 592 26 AIDS AIDS NNP cord-282610-zim7nond 592 27 : : : cord-282610-zim7nond 593 1 α α NN cord-282610-zim7nond 593 2 - - HYPH cord-282610-zim7nond 593 3 proteobacteria proteobacteria NN cord-282610-zim7nond 593 4 predominate predominate VBP cord-282610-zim7nond 593 5 independent independent JJ cord-282610-zim7nond 593 6 of of IN cord-282610-zim7nond 593 7 host host NN cord-282610-zim7nond 593 8 immune immune JJ cord-282610-zim7nond 593 9 status status NN cord-282610-zim7nond 594 1 Murine murine JJ cord-282610-zim7nond 594 2 colitis colitis NN cord-282610-zim7nond 594 3 reveals reveal VBZ cord-282610-zim7nond 594 4 a a DT cord-282610-zim7nond 594 5 disease disease NN cord-282610-zim7nond 594 6 - - HYPH cord-282610-zim7nond 594 7 associated associate VBN cord-282610-zim7nond 594 8 bacteriophage bacteriophage NN cord-282610-zim7nond 594 9 community community NN cord-282610-zim7nond 594 10 Parkinson Parkinson NNP cord-282610-zim7nond 594 11 's 's POS cord-282610-zim7nond 594 12 disease disease NN cord-282610-zim7nond 594 13 and and CC cord-282610-zim7nond 594 14 bacteriophages bacteriophage NNS cord-282610-zim7nond 594 15 as as IN cord-282610-zim7nond 594 16 its -PRON- PRP$ cord-282610-zim7nond 594 17 overlooked overlooked JJ cord-282610-zim7nond 594 18 contributors contributor NNS cord-282610-zim7nond 594 19 Distinct distinct JJ cord-282610-zim7nond 594 20 cerebrospinal cerebrospinal JJ cord-282610-zim7nond 594 21 fluid fluid NN cord-282610-zim7nond 594 22 proteomes proteome NNS cord-282610-zim7nond 594 23 differentiate differentiate VB cord-282610-zim7nond 594 24 post post JJ cord-282610-zim7nond 594 25 - - JJ cord-282610-zim7nond 594 26 treatment treatment JJ cord-282610-zim7nond 594 27 lyme lyme NNP cord-282610-zim7nond 594 28 disease disease NN cord-282610-zim7nond 594 29 from from IN cord-282610-zim7nond 594 30 chronic chronic JJ cord-282610-zim7nond 594 31 fatigue fatigue NN cord-282610-zim7nond 594 32 syndrome syndrome NN cord-282610-zim7nond 594 33 Metabolic metabolic JJ cord-282610-zim7nond 594 34 features feature NNS cord-282610-zim7nond 594 35 of of IN cord-282610-zim7nond 594 36 chronic chronic JJ cord-282610-zim7nond 594 37 fatigue fatigue NN cord-282610-zim7nond 594 38 syndrome syndrome NN cord-282610-zim7nond 594 39 Metabolism metabolism NN cord-282610-zim7nond 594 40 links link VBZ cord-282610-zim7nond 594 41 bacterial bacterial JJ cord-282610-zim7nond 594 42 biofilms biofilm NNS cord-282610-zim7nond 594 43 and and CC cord-282610-zim7nond 594 44 colon colon NN cord-282610-zim7nond 594 45 carcinogenesis carcinogenesis NN cord-282610-zim7nond 594 46 Vaginal vaginal JJ cord-282610-zim7nond 594 47 microbiota microbiota NN cord-282610-zim7nond 594 48 and and CC cord-282610-zim7nond 594 49 susceptibility susceptibility NN cord-282610-zim7nond 594 50 to to IN cord-282610-zim7nond 594 51 HIV HIV NNP cord-282610-zim7nond 594 52 Pathobionts Pathobionts NNP cord-282610-zim7nond 594 53 of of IN cord-282610-zim7nond 594 54 the the DT cord-282610-zim7nond 594 55 gastrointestinal gastrointestinal JJ cord-282610-zim7nond 594 56 microbiota microbiota NN cord-282610-zim7nond 594 57 and and CC cord-282610-zim7nond 594 58 inflammatory inflammatory JJ cord-282610-zim7nond 594 59 disease disease NN cord-282610-zim7nond 595 1 Inflammatory inflammatory JJ cord-282610-zim7nond 595 2 disease disease NN cord-282610-zim7nond 595 3 caused cause VBN cord-282610-zim7nond 595 4 by by IN cord-282610-zim7nond 595 5 intestinal intestinal JJ cord-282610-zim7nond 595 6 pathobionts pathobiont NNS cord-282610-zim7nond 595 7 Functional functional JJ cord-282610-zim7nond 595 8 signatures signature NNS cord-282610-zim7nond 595 9 of of IN cord-282610-zim7nond 595 10 oral oral JJ cord-282610-zim7nond 595 11 dysbiosis dysbiosis NN cord-282610-zim7nond 595 12 during during IN cord-282610-zim7nond 595 13 periodontitis periodontitis NN cord-282610-zim7nond 595 14 progression progression NN cord-282610-zim7nond 595 15 revealed reveal VBN cord-282610-zim7nond 595 16 by by IN cord-282610-zim7nond 595 17 microbial microbial JJ cord-282610-zim7nond 595 18 metatranscriptome metatranscriptome NNP cord-282610-zim7nond 595 19 analysis analysis NN cord-282610-zim7nond 595 20 Streptococcus Streptococcus NNP cord-282610-zim7nond 595 21 pneumoniae pneumoniae NN cord-282610-zim7nond 595 22 : : : cord-282610-zim7nond 595 23 transmission transmission NN cord-282610-zim7nond 595 24 , , , cord-282610-zim7nond 595 25 colonization colonization NN cord-282610-zim7nond 595 26 and and CC cord-282610-zim7nond 595 27 invasion invasion NN cord-282610-zim7nond 595 28 The the DT cord-282610-zim7nond 595 29 commensal commensal JJ cord-282610-zim7nond 595 30 lifestyle lifestyle NN cord-282610-zim7nond 595 31 of of IN cord-282610-zim7nond 595 32 Staphylococcus Staphylococcus NNP cord-282610-zim7nond 595 33 aureus aureus NN cord-282610-zim7nond 595 34 and and CC cord-282610-zim7nond 595 35 its -PRON- PRP$ cord-282610-zim7nond 595 36 interactions interaction NNS cord-282610-zim7nond 595 37 with with IN cord-282610-zim7nond 595 38 the the DT cord-282610-zim7nond 595 39 nasal nasal NN cord-282610-zim7nond 595 40 microbiota microbiota NN cord-282610-zim7nond 596 1 The the DT cord-282610-zim7nond 596 2 genetic genetic JJ cord-282610-zim7nond 596 3 basis basis NN cord-282610-zim7nond 596 4 of of IN cord-282610-zim7nond 596 5 Escherichia Escherichia NNP cord-282610-zim7nond 596 6 coli coli VBZ cord-282610-zim7nond 596 7 pathoadaptation pathoadaptation NN cord-282610-zim7nond 596 8 to to TO cord-282610-zim7nond 596 9 macrophages macrophages VB cord-282610-zim7nond 596 10 Bacterial bacterial JJ cord-282610-zim7nond 596 11 adaptation adaptation NN cord-282610-zim7nond 596 12 through through IN cord-282610-zim7nond 596 13 loss loss NN cord-282610-zim7nond 596 14 of of IN cord-282610-zim7nond 596 15 function function NN cord-282610-zim7nond 596 16 Bacterial bacterial JJ cord-282610-zim7nond 596 17 adaptation adaptation NN cord-282610-zim7nond 596 18 during during IN cord-282610-zim7nond 596 19 chronic chronic JJ cord-282610-zim7nond 596 20 respiratory respiratory JJ cord-282610-zim7nond 596 21 infections infection NNS cord-282610-zim7nond 597 1 Extensive extensive JJ cord-282610-zim7nond 597 2 strain strain NN cord-282610-zim7nond 597 3 - - HYPH cord-282610-zim7nond 597 4 level level NN cord-282610-zim7nond 597 5 copy copy NN cord-282610-zim7nond 597 6 - - HYPH cord-282610-zim7nond 597 7 number number NN cord-282610-zim7nond 597 8 variation variation NN cord-282610-zim7nond 597 9 across across IN cord-282610-zim7nond 597 10 human human JJ cord-282610-zim7nond 597 11 gut gut NN cord-282610-zim7nond 597 12 microbiome microbiome NN cord-282610-zim7nond 597 13 species specie NNS cord-282610-zim7nond 598 1 A a DT cord-282610-zim7nond 598 2 selective selective JJ cord-282610-zim7nond 598 3 gut gut NN cord-282610-zim7nond 598 4 bacterial bacterial JJ cord-282610-zim7nond 598 5 bile bile NN cord-282610-zim7nond 598 6 salt salt NN cord-282610-zim7nond 598 7 hydrolase hydrolase NN cord-282610-zim7nond 598 8 alters alter VBZ cord-282610-zim7nond 598 9 host host NN cord-282610-zim7nond 598 10 metabolism metabolism NN cord-282610-zim7nond 598 11 Chronic Chronic NNP cord-282610-zim7nond 598 12 fatigue fatigue NN cord-282610-zim7nond 598 13 syndrome syndrome NN cord-282610-zim7nond 598 14 from from IN cord-282610-zim7nond 598 15 vagus vagus JJ cord-282610-zim7nond 598 16 nerve nerve NN cord-282610-zim7nond 598 17 infection infection NN cord-282610-zim7nond 598 18 : : : cord-282610-zim7nond 599 1 a a DT cord-282610-zim7nond 599 2 psychoneuroimmunological psychoneuroimmunological JJ cord-282610-zim7nond 599 3 hypothesis hypothesis NN cord-282610-zim7nond 600 1 The the DT cord-282610-zim7nond 600 2 keystone keystone JJ cord-282610-zim7nond 600 3 - - HYPH cord-282610-zim7nond 600 4 pathogen pathogen NN cord-282610-zim7nond 600 5 hypothesis hypothesis NN cord-282610-zim7nond 600 6 Lowabundance Lowabundance NNP cord-282610-zim7nond 600 7 biofilm biofilm NN cord-282610-zim7nond 600 8 species specie NNS cord-282610-zim7nond 600 9 orchestrates orchestrate VBZ cord-282610-zim7nond 600 10 inflammatory inflammatory JJ cord-282610-zim7nond 600 11 periodontal periodontal JJ cord-282610-zim7nond 600 12 disease disease NN cord-282610-zim7nond 600 13 through through IN cord-282610-zim7nond 600 14 the the DT cord-282610-zim7nond 600 15 commensal commensal JJ cord-282610-zim7nond 600 16 microbiota microbiota NN cord-282610-zim7nond 600 17 and and CC cord-282610-zim7nond 600 18 complement complement VB cord-282610-zim7nond 600 19 Individuality individuality NN cord-282610-zim7nond 600 20 , , , cord-282610-zim7nond 600 21 phenotypic phenotypic JJ cord-282610-zim7nond 600 22 differentiation differentiation NN cord-282610-zim7nond 600 23 , , , cord-282610-zim7nond 600 24 dormancy dormancy NN cord-282610-zim7nond 600 25 and and CC cord-282610-zim7nond 600 26 ' ' `` cord-282610-zim7nond 600 27 persistence persistence NN cord-282610-zim7nond 600 28 ' ' '' cord-282610-zim7nond 600 29 in in IN cord-282610-zim7nond 600 30 culturable culturable JJ cord-282610-zim7nond 600 31 bacterial bacterial JJ cord-282610-zim7nond 600 32 systems system NNS cord-282610-zim7nond 600 33 : : : cord-282610-zim7nond 600 34 commonalities commonality NNS cord-282610-zim7nond 600 35 shared share VBN cord-282610-zim7nond 600 36 by by IN cord-282610-zim7nond 600 37 environmental environmental JJ cord-282610-zim7nond 600 38 , , , cord-282610-zim7nond 600 39 laboratory laboratory NN cord-282610-zim7nond 600 40 , , , cord-282610-zim7nond 600 41 and and CC cord-282610-zim7nond 600 42 clinical clinical JJ cord-282610-zim7nond 600 43 microbiology microbiology NN cord-282610-zim7nond 600 44 . . . cord-282610-zim7nond 601 1 Version version NN cord-282610-zim7nond 601 2 2 2 CD cord-282610-zim7nond 601 3 . . . cord-282610-zim7nond 602 1 F1000Res F1000Res NNP cord-282610-zim7nond 602 2 Intracellular Intracellular NNP cord-282610-zim7nond 602 3 replication replication NN cord-282610-zim7nond 602 4 of of IN cord-282610-zim7nond 602 5 Streptococcus streptococcus NN cord-282610-zim7nond 602 6 pneumoniae pneumoniae NN cord-282610-zim7nond 602 7 inside inside IN cord-282610-zim7nond 602 8 splenic splenic JJ cord-282610-zim7nond 602 9 macrophages macrophage NNS cord-282610-zim7nond 602 10 serves serve VBZ cord-282610-zim7nond 602 11 as as IN cord-282610-zim7nond 602 12 a a DT cord-282610-zim7nond 602 13 reservoir reservoir NN cord-282610-zim7nond 602 14 for for IN cord-282610-zim7nond 602 15 septicaemia septicaemia NN cord-282610-zim7nond 602 16 Epigenetic epigenetic JJ cord-282610-zim7nond 602 17 matters matter NNS cord-282610-zim7nond 602 18 : : : cord-282610-zim7nond 602 19 the the DT cord-282610-zim7nond 602 20 link link NN cord-282610-zim7nond 602 21 between between IN cord-282610-zim7nond 602 22 early early JJ cord-282610-zim7nond 602 23 nutrition nutrition NN cord-282610-zim7nond 602 24 , , , cord-282610-zim7nond 602 25 microbiome microbiome NN cord-282610-zim7nond 602 26 , , , cord-282610-zim7nond 602 27 and and CC cord-282610-zim7nond 602 28 long long JJ cord-282610-zim7nond 602 29 - - HYPH cord-282610-zim7nond 602 30 term term NN cord-282610-zim7nond 602 31 health health NN cord-282610-zim7nond 602 32 development development NN cord-282610-zim7nond 602 33 . . . cord-282610-zim7nond 603 1 Front Front NNP cord-282610-zim7nond 603 2 Pediatr Pediatr NNP cord-282610-zim7nond 603 3 Using use VBG cord-282610-zim7nond 603 4 a a DT cord-282610-zim7nond 603 5 cDNA cdna NN cord-282610-zim7nond 603 6 microarray microarray NN cord-282610-zim7nond 603 7 to to TO cord-282610-zim7nond 603 8 study study VB cord-282610-zim7nond 603 9 cellular cellular JJ cord-282610-zim7nond 603 10 gene gene NN cord-282610-zim7nond 603 11 expression expression NN cord-282610-zim7nond 603 12 altered alter VBN cord-282610-zim7nond 603 13 by by IN cord-282610-zim7nond 603 14 Mycobacterium Mycobacterium NNP cord-282610-zim7nond 603 15 tuberculosis tuberculosis NN cord-282610-zim7nond 603 16 Helicobacter Helicobacter NNP cord-282610-zim7nond 603 17 pylori pylori NN cord-282610-zim7nond 603 18 infection infection NN cord-282610-zim7nond 603 19 introduces introduce VBZ cord-282610-zim7nond 603 20 DNA dna NN cord-282610-zim7nond 603 21 double double JJ cord-282610-zim7nond 603 22 - - HYPH cord-282610-zim7nond 603 23 strand strand NN cord-282610-zim7nond 603 24 breaks break NNS cord-282610-zim7nond 603 25 in in IN cord-282610-zim7nond 603 26 host host NN cord-282610-zim7nond 603 27 cells cell NNS cord-282610-zim7nond 603 28 Characterization characterization NN cord-282610-zim7nond 603 29 of of IN cord-282610-zim7nond 603 30 the the DT cord-282610-zim7nond 603 31 EBV EBV NNP cord-282610-zim7nond 603 32 - - HYPH cord-282610-zim7nond 603 33 induced induce VBN cord-282610-zim7nond 603 34 persistent persistent JJ cord-282610-zim7nond 603 35 DNA dna NN cord-282610-zim7nond 603 36 damage damage NN cord-282610-zim7nond 603 37 response response NN cord-282610-zim7nond 603 38 Crosstalk crosstalk NN cord-282610-zim7nond 603 39 between between IN cord-282610-zim7nond 603 40 the the DT cord-282610-zim7nond 603 41 microbiome microbiome NN cord-282610-zim7nond 603 42 and and CC cord-282610-zim7nond 603 43 cancer cancer NN cord-282610-zim7nond 603 44 cells cell NNS cord-282610-zim7nond 603 45 by by IN cord-282610-zim7nond 603 46 quorum quorum NN cord-282610-zim7nond 603 47 sensing sensing NN cord-282610-zim7nond 603 48 peptides peptide NNS cord-282610-zim7nond 604 1 Nanotubular Nanotubular NNP cord-282610-zim7nond 604 2 highways highway NNS cord-282610-zim7nond 604 3 for for IN cord-282610-zim7nond 604 4 intercellular intercellular JJ cord-282610-zim7nond 604 5 organelle organelle NN cord-282610-zim7nond 604 6 transport transport NN cord-282610-zim7nond 604 7 Potential potential JJ cord-282610-zim7nond 604 8 role role NN cord-282610-zim7nond 604 9 of of IN cord-282610-zim7nond 604 10 the the DT cord-282610-zim7nond 604 11 formation formation NN cord-282610-zim7nond 604 12 of of IN cord-282610-zim7nond 604 13 tunneling tunnel VBG cord-282610-zim7nond 604 14 nanotubes nanotube NNS cord-282610-zim7nond 604 15 in in IN cord-282610-zim7nond 604 16 HIV-1 HIV-1 NNP cord-282610-zim7nond 604 17 spread spread VBD cord-282610-zim7nond 604 18 in in IN cord-282610-zim7nond 604 19 macrophages macrophage NNS cord-282610-zim7nond 604 20 Prion prion NN cord-282610-zim7nond 604 21 aggregates aggregate NNS cord-282610-zim7nond 604 22 transfer transfer VBP cord-282610-zim7nond 604 23 through through IN cord-282610-zim7nond 604 24 tunneling tunnel VBG cord-282610-zim7nond 604 25 nanotubes nanotube NNS cord-282610-zim7nond 604 26 in in IN cord-282610-zim7nond 604 27 endocytic endocytic JJ cord-282610-zim7nond 604 28 vesicles vesicle NNS cord-282610-zim7nond 605 1 Intercellular Intercellular NNP cord-282610-zim7nond 605 2 mRNA mRNA NNP cord-282610-zim7nond 606 1 trafficking traffic VBG cord-282610-zim7nond 606 2 via via IN cord-282610-zim7nond 606 3 membrane membrane NN cord-282610-zim7nond 606 4 nanotube nanotube NN cord-282610-zim7nond 606 5 - - HYPH cord-282610-zim7nond 606 6 like like JJ cord-282610-zim7nond 606 7 extensions extension NNS cord-282610-zim7nond 606 8 in in IN cord-282610-zim7nond 606 9 mammalian mammalian JJ cord-282610-zim7nond 606 10 cells cell NNS cord-282610-zim7nond 607 1 Viral viral JJ cord-282610-zim7nond 607 2 insulin insulin NN cord-282610-zim7nond 607 3 - - HYPH cord-282610-zim7nond 607 4 like like JJ cord-282610-zim7nond 607 5 peptides peptide NNS cord-282610-zim7nond 607 6 activate activate VBP cord-282610-zim7nond 607 7 human human JJ cord-282610-zim7nond 607 8 insulin insulin NN cord-282610-zim7nond 607 9 and and CC cord-282610-zim7nond 607 10 IGF-1 IGF-1 NNP cord-282610-zim7nond 607 11 receptor receptor NN cord-282610-zim7nond 607 12 signaling signaling NN cord-282610-zim7nond 607 13 : : : cord-282610-zim7nond 608 1 A a DT cord-282610-zim7nond 608 2 paradigm paradigm NN cord-282610-zim7nond 608 3 shift shift NN cord-282610-zim7nond 608 4 for for IN cord-282610-zim7nond 608 5 host host NN cord-282610-zim7nond 608 6 - - HYPH cord-282610-zim7nond 608 7 microbe microbe NN cord-282610-zim7nond 608 8 interactions interaction NNS cord-282610-zim7nond 609 1 Bacteria Bacteria NNS cord-282610-zim7nond 609 2 - - HYPH cord-282610-zim7nond 609 3 tohuman tohuman NN cord-282610-zim7nond 609 4 protein protein NN cord-282610-zim7nond 609 5 networks network NNS cord-282610-zim7nond 609 6 reveal reveal VBP cord-282610-zim7nond 609 7 origins origin NNS cord-282610-zim7nond 609 8 of of IN cord-282610-zim7nond 609 9 endogenous endogenous JJ cord-282610-zim7nond 609 10 DNA dna NN cord-282610-zim7nond 609 11 damage damage NN cord-282610-zim7nond 609 12 Extracellular Extracellular NNP cord-282610-zim7nond 609 13 vesicles vesicle NNS cord-282610-zim7nond 609 14 and and CC cord-282610-zim7nond 609 15 viruses virus NNS cord-282610-zim7nond 609 16 : : : cord-282610-zim7nond 609 17 Are be VBP cord-282610-zim7nond 609 18 they -PRON- PRP cord-282610-zim7nond 609 19 close close VBP cord-282610-zim7nond 609 20 relatives relative NNS cord-282610-zim7nond 609 21 ? ? . cord-282610-zim7nond 610 1 Large large JJ cord-282610-zim7nond 610 2 - - HYPH cord-282610-zim7nond 610 3 scale scale NN cord-282610-zim7nond 610 4 in in IN cord-282610-zim7nond 610 5 silico silico NN cord-282610-zim7nond 610 6 and and CC cord-282610-zim7nond 610 7 microarray microarray NN cord-282610-zim7nond 610 8 - - HYPH cord-282610-zim7nond 610 9 based base VBN cord-282610-zim7nond 610 10 identification identification NN cord-282610-zim7nond 610 11 of of IN cord-282610-zim7nond 610 12 direct direct JJ cord-282610-zim7nond 610 13 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-282610-zim7nond 610 14 D3 D3 NNP cord-282610-zim7nond 610 15 target target NN cord-282610-zim7nond 610 16 genes gene NNS cord-282610-zim7nond 610 17 Vitamin vitamin NN cord-282610-zim7nond 610 18 D d NN cord-282610-zim7nond 610 19 , , , cord-282610-zim7nond 610 20 vitamin vitamin NN cord-282610-zim7nond 610 21 D d NN cord-282610-zim7nond 610 22 receptor receptor NN cord-282610-zim7nond 610 23 , , , cord-282610-zim7nond 610 24 and and CC cord-282610-zim7nond 610 25 macroautophagy macroautophagy NNS cord-282610-zim7nond 610 26 in in IN cord-282610-zim7nond 610 27 inflammation inflammation NN cord-282610-zim7nond 610 28 and and CC cord-282610-zim7nond 610 29 infection infection NN cord-282610-zim7nond 610 30 Methylation methylation NN cord-282610-zim7nond 610 31 of of IN cord-282610-zim7nond 610 32 the the DT cord-282610-zim7nond 610 33 Vitamin vitamin NN cord-282610-zim7nond 610 34 D D NNP cord-282610-zim7nond 610 35 Receptor Receptor NNP cord-282610-zim7nond 610 36 ( ( -LRB- cord-282610-zim7nond 610 37 VDR VDR NNP cord-282610-zim7nond 610 38 ) ) -RRB- cord-282610-zim7nond 610 39 gene gene NN cord-282610-zim7nond 610 40 , , , cord-282610-zim7nond 610 41 together together RB cord-282610-zim7nond 610 42 with with IN cord-282610-zim7nond 610 43 genetic genetic JJ cord-282610-zim7nond 610 44 variation variation NN cord-282610-zim7nond 610 45 , , , cord-282610-zim7nond 610 46 race race NN cord-282610-zim7nond 610 47 , , , cord-282610-zim7nond 610 48 and and CC cord-282610-zim7nond 610 49 environment environment NN cord-282610-zim7nond 610 50 influence influence VBP cord-282610-zim7nond 610 51 the the DT cord-282610-zim7nond 610 52 signaling signal VBG cord-282610-zim7nond 610 53 efficacy efficacy NN cord-282610-zim7nond 610 54 of of IN cord-282610-zim7nond 610 55 the the DT cord-282610-zim7nond 610 56 toll toll NN cord-282610-zim7nond 610 57 - - HYPH cord-282610-zim7nond 610 58 like like JJ cord-282610-zim7nond 610 59 receptor receptor NN cord-282610-zim7nond 610 60 2/1-VDR 2/1-VDR NNP cord-282610-zim7nond 610 61 pathway pathway NN cord-282610-zim7nond 610 62 . . . cord-282610-zim7nond 611 1 Front Front NNP cord-282610-zim7nond 611 2 Immunol Immunol NNP cord-282610-zim7nond 611 3 Expression Expression NNP cord-282610-zim7nond 611 4 profile profile NN cord-282610-zim7nond 611 5 of of IN cord-282610-zim7nond 611 6 nuclear nuclear JJ cord-282610-zim7nond 611 7 receptors receptor NNS cord-282610-zim7nond 611 8 upon upon IN cord-282610-zim7nond 611 9 Epstein Epstein NNP cord-282610-zim7nond 611 10 -Barr -Barr NNP cord-282610-zim7nond 611 11 virus virus NN cord-282610-zim7nond 611 12 induced induce VBN cord-282610-zim7nond 611 13 B b NN cord-282610-zim7nond 611 14 cell cell NN cord-282610-zim7nond 611 15 transformation transformation NN cord-282610-zim7nond 611 16 Activation activation NN cord-282610-zim7nond 611 17 of of IN cord-282610-zim7nond 611 18 the the DT cord-282610-zim7nond 611 19 human human JJ cord-282610-zim7nond 611 20 immunodeficiency immunodeficiency NN cord-282610-zim7nond 611 21 virus virus NN cord-282610-zim7nond 611 22 type type NN cord-282610-zim7nond 612 1 I -PRON- PRP cord-282610-zim7nond 612 2 long long RB cord-282610-zim7nond 612 3 terminal terminal JJ cord-282610-zim7nond 612 4 repeat repeat NN cord-282610-zim7nond 612 5 by by IN cord-282610-zim7nond 612 6 1 1 CD cord-282610-zim7nond 612 7 alpha,25-dihydroxyvitamin alpha,25-dihydroxyvitamin CD cord-282610-zim7nond 612 8 D3 D3 NNP cord-282610-zim7nond 612 9 Transcriptome Transcriptome NNP cord-282610-zim7nond 612 10 analysis analysis NN cord-282610-zim7nond 612 11 reveals reveal VBZ cord-282610-zim7nond 612 12 human human JJ cord-282610-zim7nond 612 13 cytomegalovirus cytomegalovirus NN cord-282610-zim7nond 612 14 reprograms reprogram VBZ cord-282610-zim7nond 612 15 monocyte monocyte NNP cord-282610-zim7nond 612 16 differentiation differentiation NN cord-282610-zim7nond 612 17 toward toward IN cord-282610-zim7nond 612 18 an an DT cord-282610-zim7nond 612 19 M1 M1 NNP cord-282610-zim7nond 612 20 macrophage macrophage NN cord-282610-zim7nond 612 21 Activation activation NN cord-282610-zim7nond 612 22 of of IN cord-282610-zim7nond 612 23 human human JJ cord-282610-zim7nond 612 24 monocytes monocyte NNS cord-282610-zim7nond 612 25 by by IN cord-282610-zim7nond 612 26 live live JJ cord-282610-zim7nond 612 27 Borrelia Borrelia NNP cord-282610-zim7nond 612 28 burgdorferi burgdorferi NN cord-282610-zim7nond 612 29 generates generate VBZ cord-282610-zim7nond 612 30 TLR2-dependent TLR2-dependent NNP cord-282610-zim7nond 612 31 and and CC cord-282610-zim7nond 612 32 -independent -independent JJ cord-282610-zim7nond 612 33 responses response NNS cord-282610-zim7nond 612 34 which which WDT cord-282610-zim7nond 612 35 include include VBP cord-282610-zim7nond 612 36 induction induction NN cord-282610-zim7nond 612 37 of of IN cord-282610-zim7nond 612 38 IFN IFN NNP cord-282610-zim7nond 612 39 - - HYPH cord-282610-zim7nond 612 40 beta beta NNP cord-282610-zim7nond 612 41 MicroRNA-21 MicroRNA-21 NNP cord-282610-zim7nond 612 42 targets target VBZ cord-282610-zim7nond 612 43 the the DT cord-282610-zim7nond 612 44 vitamin vitamin NN cord-282610-zim7nond 612 45 D d NN cord-282610-zim7nond 612 46 - - HYPH cord-282610-zim7nond 612 47 dependent dependent JJ cord-282610-zim7nond 612 48 antimicrobial antimicrobial JJ cord-282610-zim7nond 612 49 pathway pathway NN cord-282610-zim7nond 612 50 in in IN cord-282610-zim7nond 612 51 leprosy leprosy NN cord-282610-zim7nond 613 1 The the DT cord-282610-zim7nond 613 2 effect effect NN cord-282610-zim7nond 613 3 of of IN cord-282610-zim7nond 613 4 Aspergillus aspergillus NN cord-282610-zim7nond 613 5 fumigatus fumigatus NN cord-282610-zim7nond 613 6 infection infection NN cord-282610-zim7nond 613 7 on on IN cord-282610-zim7nond 613 8 vitamin vitamin NN cord-282610-zim7nond 613 9 D D NNP cord-282610-zim7nond 613 10 receptor receptor NN cord-282610-zim7nond 613 11 expression expression NN cord-282610-zim7nond 613 12 in in IN cord-282610-zim7nond 613 13 cystic cystic JJ cord-282610-zim7nond 613 14 fibrosis fibrosis NN cord-282610-zim7nond 614 1 The the DT cord-282610-zim7nond 614 2 pancreatic pancreatic JJ cord-282610-zim7nond 614 3 cancer cancer NN cord-282610-zim7nond 614 4 microbiome microbiome NN cord-282610-zim7nond 614 5 promotes promote VBZ cord-282610-zim7nond 614 6 oncogenesis oncogenesis NN cord-282610-zim7nond 614 7 by by IN cord-282610-zim7nond 614 8 induction induction NN cord-282610-zim7nond 614 9 of of IN cord-282610-zim7nond 614 10 innate innate JJ cord-282610-zim7nond 614 11 and and CC cord-282610-zim7nond 614 12 adaptive adaptive JJ cord-282610-zim7nond 614 13 immune immune JJ cord-282610-zim7nond 614 14 suppression suppression NN cord-282610-zim7nond 615 1 Coordinated coordinated JJ cord-282610-zim7nond 615 2 host host NN cord-282610-zim7nond 615 3 - - HYPH cord-282610-zim7nond 615 4 pathogen pathogen NN cord-282610-zim7nond 615 5 transcriptional transcriptional JJ cord-282610-zim7nond 615 6 dynamics dynamic NNS cord-282610-zim7nond 615 7 revealed reveal VBD cord-282610-zim7nond 615 8 using use VBG cord-282610-zim7nond 615 9 sorted sort VBN cord-282610-zim7nond 615 10 subpopulations subpopulation NNS cord-282610-zim7nond 615 11 and and CC cord-282610-zim7nond 615 12 single single JJ cord-282610-zim7nond 615 13 T t NN cord-282610-zim7nond 615 14 - - HYPH cord-282610-zim7nond 615 15 cell cell NN cord-282610-zim7nond 615 16 exhaustion exhaustion NN cord-282610-zim7nond 615 17 , , , cord-282610-zim7nond 615 18 co co NN cord-282610-zim7nond 615 19 - - NN cord-282610-zim7nond 615 20 stimulation stimulation NN cord-282610-zim7nond 615 21 and and CC cord-282610-zim7nond 615 22 clinical clinical JJ cord-282610-zim7nond 615 23 outcome outcome NN cord-282610-zim7nond 615 24 in in IN cord-282610-zim7nond 615 25 autoimmunity autoimmunity NN cord-282610-zim7nond 615 26 and and CC cord-282610-zim7nond 615 27 infection infection NN cord-282610-zim7nond 616 1 The the DT cord-282610-zim7nond 616 2 epigenetic epigenetic JJ cord-282610-zim7nond 616 3 landscape landscape NN cord-282610-zim7nond 616 4 of of IN cord-282610-zim7nond 616 5 T T NNP cord-282610-zim7nond 616 6 cell cell NN cord-282610-zim7nond 616 7 exhaustion exhaustion NN cord-282610-zim7nond 616 8 Proof Proof NNP cord-282610-zim7nond 616 9 that that IN cord-282610-zim7nond 616 10 chronic chronic JJ cord-282610-zim7nond 616 11 lyme lyme NNP cord-282610-zim7nond 616 12 disease disease NN cord-282610-zim7nond 616 13 exists exist VBZ cord-282610-zim7nond 616 14 Zika Zika NNP cord-282610-zim7nond 616 15 virus virus NN cord-282610-zim7nond 616 16 persistence persistence NN cord-282610-zim7nond 616 17 in in IN cord-282610-zim7nond 616 18 the the DT cord-282610-zim7nond 616 19 central central JJ cord-282610-zim7nond 616 20 nervous nervous JJ cord-282610-zim7nond 616 21 system system NN cord-282610-zim7nond 616 22 and and CC cord-282610-zim7nond 616 23 lymph lymph NN cord-282610-zim7nond 616 24 nodes node NNS cord-282610-zim7nond 616 25 of of IN cord-282610-zim7nond 616 26 rhesus rhesu NNS cord-282610-zim7nond 616 27 monkeys monkey NNS cord-282610-zim7nond 616 28 post post VBP cord-282610-zim7nond 616 29 - - JJ cord-282610-zim7nond 616 30 ebola ebola NNP cord-282610-zim7nond 616 31 syndrome syndrome NN cord-282610-zim7nond 616 32 among among IN cord-282610-zim7nond 616 33 ebola ebola NNP cord-282610-zim7nond 616 34 virus virus NN cord-282610-zim7nond 616 35 disease disease NN cord-282610-zim7nond 616 36 survivors survivor NNS cord-282610-zim7nond 616 37 in in IN cord-282610-zim7nond 616 38 Montserrado Montserrado NNP cord-282610-zim7nond 616 39 County County NNP cord-282610-zim7nond 616 40 , , , cord-282610-zim7nond 616 41 Liberia Liberia NNP cord-282610-zim7nond 616 42 Ebola Ebola NNP cord-282610-zim7nond 616 43 virus virus NN cord-282610-zim7nond 616 44 ribonucleic ribonucleic NN cord-282610-zim7nond 616 45 acid acid NN cord-282610-zim7nond 616 46 detection detection NN cord-282610-zim7nond 616 47 in in IN cord-282610-zim7nond 616 48 semen semen NN cord-282610-zim7nond 616 49 more more JJR cord-282610-zim7nond 616 50 than than IN cord-282610-zim7nond 616 51 two two CD cord-282610-zim7nond 616 52 years year NNS cord-282610-zim7nond 616 53 after after IN cord-282610-zim7nond 616 54 resolution resolution NN cord-282610-zim7nond 616 55 of of IN cord-282610-zim7nond 616 56 acute acute JJ cord-282610-zim7nond 616 57 ebola ebola NNP cord-282610-zim7nond 616 58 virus virus NN cord-282610-zim7nond 616 59 infection infection NN cord-282610-zim7nond 616 60 . . . cord-282610-zim7nond 617 1 Open Open NNP cord-282610-zim7nond 617 2 Forum Forum NNP cord-282610-zim7nond 618 1 Infect infect VB cord-282610-zim7nond 618 2 Dis Dis NNP cord-282610-zim7nond 618 3 Long long JJ cord-282610-zim7nond 618 4 - - HYPH cord-282610-zim7nond 618 5 term term NN cord-282610-zim7nond 618 6 neuroinflammation neuroinflammation NN cord-282610-zim7nond 618 7 induced induce VBN cord-282610-zim7nond 618 8 by by IN cord-282610-zim7nond 618 9 influenza influenza NN cord-282610-zim7nond 618 10 a a DT cord-282610-zim7nond 618 11 virus virus NN cord-282610-zim7nond 618 12 infection infection NN cord-282610-zim7nond 618 13 and and CC cord-282610-zim7nond 618 14 the the DT cord-282610-zim7nond 618 15 impact impact NN cord-282610-zim7nond 618 16 on on IN cord-282610-zim7nond 618 17 hippocampal hippocampal JJ cord-282610-zim7nond 618 18 neuron neuron NN cord-282610-zim7nond 618 19 morphology morphology NN cord-282610-zim7nond 618 20 and and CC cord-282610-zim7nond 618 21 function function VB cord-282610-zim7nond 618 22 Persistent persistent JJ cord-282610-zim7nond 618 23 measles measle NNS cord-282610-zim7nond 618 24 virus virus NN cord-282610-zim7nond 618 25 infection infection NN cord-282610-zim7nond 618 26 in in IN cord-282610-zim7nond 618 27 vitro vitro FW cord-282610-zim7nond 618 28 and and CC cord-282610-zim7nond 618 29 in in IN cord-282610-zim7nond 618 30 man man NN cord-282610-zim7nond 619 1 Crohn Crohn NNP cord-282610-zim7nond 619 2 's 's POS cord-282610-zim7nond 619 3 disease disease NN cord-282610-zim7nond 619 4 : : : cord-282610-zim7nond 619 5 pathogenesis pathogenesis NN cord-282610-zim7nond 619 6 and and CC cord-282610-zim7nond 619 7 persistent persistent JJ cord-282610-zim7nond 619 8 measles measle NNS cord-282610-zim7nond 619 9 virus virus NN cord-282610-zim7nond 619 10 infection infection NN cord-282610-zim7nond 619 11 Measles Measles NNP cord-282610-zim7nond 619 12 virus virus NN cord-282610-zim7nond 619 13 , , , cord-282610-zim7nond 619 14 immune immune JJ cord-282610-zim7nond 619 15 control control NN cord-282610-zim7nond 619 16 , , , cord-282610-zim7nond 619 17 and and CC cord-282610-zim7nond 619 18 persistence persistence NN cord-282610-zim7nond 619 19 Measles Measles NNP cord-282610-zim7nond 619 20 virus virus NN cord-282610-zim7nond 619 21 induces induce VBZ cord-282610-zim7nond 619 22 persistent persistent JJ cord-282610-zim7nond 619 23 infection infection NN cord-282610-zim7nond 619 24 by by IN cord-282610-zim7nond 619 25 autoregulation autoregulation NN cord-282610-zim7nond 619 26 of of IN cord-282610-zim7nond 619 27 viral viral JJ cord-282610-zim7nond 619 28 replication replication NN cord-282610-zim7nond 619 29 Bacterial Bacterial NNP cord-282610-zim7nond 619 30 L l NN cord-282610-zim7nond 619 31 - - HYPH cord-282610-zim7nond 619 32 forms form NNS cord-282610-zim7nond 619 33 require require VBP cord-282610-zim7nond 619 34 peptidoglycan peptidoglycan JJ cord-282610-zim7nond 619 35 synthesis synthesis NN cord-282610-zim7nond 619 36 for for IN cord-282610-zim7nond 619 37 cell cell NN cord-282610-zim7nond 619 38 division division NN cord-282610-zim7nond 619 39 Insights insight NNS cord-282610-zim7nond 619 40 into into IN cord-282610-zim7nond 619 41 the the DT cord-282610-zim7nond 619 42 molecular molecular JJ cord-282610-zim7nond 619 43 basis basis NN cord-282610-zim7nond 619 44 of of IN cord-282610-zim7nond 619 45 L l NN cord-282610-zim7nond 619 46 - - HYPH cord-282610-zim7nond 619 47 form form NN cord-282610-zim7nond 619 48 formation formation NN cord-282610-zim7nond 619 49 and and CC cord-282610-zim7nond 619 50 survival survival NN cord-282610-zim7nond 619 51 in in IN cord-282610-zim7nond 619 52 Escherichia Escherichia NNP cord-282610-zim7nond 619 53 coli coli VBZ cord-282610-zim7nond 619 54 L l NN cord-282610-zim7nond 619 55 - - HYPH cord-282610-zim7nond 619 56 form form NN cord-282610-zim7nond 619 57 bacteria bacteria NNS cord-282610-zim7nond 619 58 cohabitants cohabitant NNS cord-282610-zim7nond 619 59 in in IN cord-282610-zim7nond 619 60 human human JJ cord-282610-zim7nond 619 61 blood blood NN cord-282610-zim7nond 619 62 : : : cord-282610-zim7nond 619 63 significance significance NN cord-282610-zim7nond 619 64 for for IN cord-282610-zim7nond 619 65 health health NN cord-282610-zim7nond 619 66 and and CC cord-282610-zim7nond 619 67 diseases disease NNS cord-282610-zim7nond 619 68 Cell Cell NNP cord-282610-zim7nond 619 69 Wall Wall NNP cord-282610-zim7nond 619 70 Deficient Deficient NNP cord-282610-zim7nond 619 71 Forms Forms NNP cord-282610-zim7nond 619 72 : : : cord-282610-zim7nond 620 1 Stealth Stealth NNP cord-282610-zim7nond 620 2 Pathogens Pathogens NNPS cord-282610-zim7nond 620 3 Parallels Parallels NNPS cord-282610-zim7nond 620 4 between between IN cord-282610-zim7nond 620 5 post post JJ cord-282610-zim7nond 620 6 - - JJ cord-282610-zim7nond 620 7 polio polio JJ cord-282610-zim7nond 620 8 fatigue fatigue NN cord-282610-zim7nond 620 9 and and CC cord-282610-zim7nond 620 10 chronic chronic JJ cord-282610-zim7nond 620 11 fatigue fatigue NN cord-282610-zim7nond 620 12 syndrome syndrome NN cord-282610-zim7nond 620 13 : : : cord-282610-zim7nond 620 14 a a DT cord-282610-zim7nond 620 15 common common JJ cord-282610-zim7nond 620 16 pathophysiology pathophysiology NN cord-282610-zim7nond 620 17 ? ? . cord-282610-zim7nond 621 1 The the DT cord-282610-zim7nond 621 2 chronic chronic JJ cord-282610-zim7nond 621 3 mononucleosis mononucleosis NN cord-282610-zim7nond 621 4 syndrome syndrome NN cord-282610-zim7nond 622 1 The the DT cord-282610-zim7nond 622 2 post post JJ cord-282610-zim7nond 622 3 - - JJ cord-282610-zim7nond 622 4 viral viral JJ cord-282610-zim7nond 622 5 syndrome syndrome NN cord-282610-zim7nond 622 6 : : : cord-282610-zim7nond 622 7 a a DT cord-282610-zim7nond 622 8 review review NN cord-282610-zim7nond 622 9 Acute acute JJ cord-282610-zim7nond 622 10 enterovirus enterovirus NN cord-282610-zim7nond 622 11 infection infection NN cord-282610-zim7nond 622 12 followed follow VBN cord-282610-zim7nond 622 13 by by IN cord-282610-zim7nond 622 14 myalgic myalgic JJ cord-282610-zim7nond 622 15 encephalomyelitis encephalomyelitis NN cord-282610-zim7nond 622 16 / / SYM cord-282610-zim7nond 622 17 chronic chronic JJ cord-282610-zim7nond 622 18 fatigue fatigue NN cord-282610-zim7nond 622 19 syndrome syndrome NN cord-282610-zim7nond 622 20 ( ( -LRB- cord-282610-zim7nond 622 21 ME ME NNP cord-282610-zim7nond 622 22 / / SYM cord-282610-zim7nond 622 23 CFS CFS NNP cord-282610-zim7nond 622 24 ) ) -RRB- cord-282610-zim7nond 622 25 and and CC cord-282610-zim7nond 622 26 viral viral JJ cord-282610-zim7nond 622 27 persistence persistence NN cord-282610-zim7nond 622 28 HIV HIV NNP cord-282610-zim7nond 622 29 and and CC cord-282610-zim7nond 622 30 co co NNS cord-282610-zim7nond 622 31 - - NNS cord-282610-zim7nond 622 32 infections infection NNS cord-282610-zim7nond 622 33 Tumour tumour NN cord-282610-zim7nond 622 34 heterogeneity heterogeneity NN cord-282610-zim7nond 622 35 in in IN cord-282610-zim7nond 622 36 the the DT cord-282610-zim7nond 622 37 clinic clinic NN cord-282610-zim7nond 622 38 Autoimmune autoimmune JJ cord-282610-zim7nond 622 39 disease disease NN cord-282610-zim7nond 622 40 and and CC cord-282610-zim7nond 622 41 the the DT cord-282610-zim7nond 622 42 human human NN cord-282610-zim7nond 622 43 metagenome metagenome NNP cord-282610-zim7nond 622 44 Long long JJ cord-282610-zim7nond 622 45 - - HYPH cord-282610-zim7nond 622 46 term term NN cord-282610-zim7nond 622 47 measlesinduced measlesinduce VBN cord-282610-zim7nond 622 48 immunomodulation immunomodulation NN cord-282610-zim7nond 622 49 increases increase VBZ cord-282610-zim7nond 622 50 overall overall RB cord-282610-zim7nond 622 51 childhood childhood NN cord-282610-zim7nond 622 52 infectious infectious JJ cord-282610-zim7nond 622 53 disease disease NN cord-282610-zim7nond 622 54 mortality mortality NN cord-282610-zim7nond 623 1 The the DT cord-282610-zim7nond 623 2 human human JJ cord-282610-zim7nond 623 3 milk milk NN cord-282610-zim7nond 623 4 microbiome microbiome NN cord-282610-zim7nond 623 5 changes change VBZ cord-282610-zim7nond 623 6 over over IN cord-282610-zim7nond 623 7 lactation lactation NN cord-282610-zim7nond 623 8 and and CC cord-282610-zim7nond 623 9 is be VBZ cord-282610-zim7nond 623 10 shaped shape VBN cord-282610-zim7nond 623 11 by by IN cord-282610-zim7nond 623 12 maternal maternal JJ cord-282610-zim7nond 623 13 weight weight NN cord-282610-zim7nond 623 14 and and CC cord-282610-zim7nond 623 15 mode mode NN cord-282610-zim7nond 623 16 of of IN cord-282610-zim7nond 623 17 delivery delivery NN cord-282610-zim7nond 623 18 Microorganisms microorganism NNS cord-282610-zim7nond 623 19 in in IN cord-282610-zim7nond 623 20 the the DT cord-282610-zim7nond 623 21 human human JJ cord-282610-zim7nond 623 22 placenta placenta NN cord-282610-zim7nond 623 23 are be VBP cord-282610-zim7nond 623 24 associated associate VBN cord-282610-zim7nond 623 25 with with IN cord-282610-zim7nond 623 26 altered alter VBN cord-282610-zim7nond 623 27 CpG cpg NN cord-282610-zim7nond 623 28 methylation methylation NN cord-282610-zim7nond 623 29 of of IN cord-282610-zim7nond 623 30 immune immune NN cord-282610-zim7nond 623 31 and and CC cord-282610-zim7nond 623 32 inflammation inflammation NN cord-282610-zim7nond 623 33 - - HYPH cord-282610-zim7nond 623 34 related relate VBN cord-282610-zim7nond 623 35 genes gene NNS cord-282610-zim7nond 624 1 The the DT cord-282610-zim7nond 624 2 effects effect NNS cord-282610-zim7nond 624 3 of of IN cord-282610-zim7nond 624 4 antibiotics antibiotic NNS cord-282610-zim7nond 624 5 on on IN cord-282610-zim7nond 624 6 the the DT cord-282610-zim7nond 624 7 microbiome microbiome NN cord-282610-zim7nond 624 8 throughout throughout IN cord-282610-zim7nond 624 9 development development NN cord-282610-zim7nond 624 10 and and CC cord-282610-zim7nond 624 11 alternative alternative JJ cord-282610-zim7nond 624 12 approaches approach NNS cord-282610-zim7nond 624 13 for for IN cord-282610-zim7nond 624 14 therapeutic therapeutic JJ cord-282610-zim7nond 624 15 modulation modulation NN cord-282610-zim7nond 625 1 Multidrugresistant Multidrugresistant NNP cord-282610-zim7nond 625 2 enterococci enterococci NNS cord-282610-zim7nond 625 3 in in IN cord-282610-zim7nond 625 4 animal animal NN cord-282610-zim7nond 625 5 meat meat NN cord-282610-zim7nond 625 6 and and CC cord-282610-zim7nond 625 7 faeces faece NNS cord-282610-zim7nond 625 8 and and CC cord-282610-zim7nond 625 9 co co NN cord-282610-zim7nond 625 10 - - NN cord-282610-zim7nond 625 11 transfer transfer NN cord-282610-zim7nond 625 12 of of IN cord-282610-zim7nond 625 13 resistance resistance NN cord-282610-zim7nond 625 14 from from IN cord-282610-zim7nond 625 15 an an DT cord-282610-zim7nond 625 16 Enterococcus Enterococcus NNP cord-282610-zim7nond 625 17 durans duran NNS cord-282610-zim7nond 625 18 to to IN cord-282610-zim7nond 625 19 a a DT cord-282610-zim7nond 625 20 human human JJ cord-282610-zim7nond 625 21 Enterococcus Enterococcus NNP cord-282610-zim7nond 625 22 faecium faecium NN cord-282610-zim7nond 625 23 Suppression suppression NN cord-282610-zim7nond 625 24 of of IN cord-282610-zim7nond 625 25 nonspecific nonspecific JJ cord-282610-zim7nond 625 26 resistance resistance NN cord-282610-zim7nond 625 27 of of IN cord-282610-zim7nond 625 28 the the DT cord-282610-zim7nond 625 29 body body NN cord-282610-zim7nond 625 30 under under IN cord-282610-zim7nond 625 31 the the DT cord-282610-zim7nond 625 32 effect effect NN cord-282610-zim7nond 625 33 of of IN cord-282610-zim7nond 625 34 extremely extremely RB cord-282610-zim7nond 625 35 high high JJ cord-282610-zim7nond 625 36 frequency frequency NN cord-282610-zim7nond 625 37 electromagnetic electromagnetic JJ cord-282610-zim7nond 625 38 radiation radiation NN cord-282610-zim7nond 625 39 of of IN cord-282610-zim7nond 625 40 low low JJ cord-282610-zim7nond 625 41 intensity intensity NN cord-282610-zim7nond 625 42 Transplantation transplantation NN cord-282610-zim7nond 625 43 - - HYPH cord-282610-zim7nond 625 44 associated associate VBN cord-282610-zim7nond 625 45 long long JJ cord-282610-zim7nond 625 46 - - HYPH cord-282610-zim7nond 625 47 term term NN cord-282610-zim7nond 625 48 immunosuppression immunosuppression NN cord-282610-zim7nond 625 49 promotes promote VBZ cord-282610-zim7nond 625 50 oral oral JJ cord-282610-zim7nond 625 51 colonization colonization NN cord-282610-zim7nond 625 52 by by IN cord-282610-zim7nond 625 53 potentially potentially RB cord-282610-zim7nond 625 54 opportunistic opportunistic JJ cord-282610-zim7nond 625 55 pathogens pathogen NNS cord-282610-zim7nond 625 56 without without IN cord-282610-zim7nond 625 57 impacting impact VBG cord-282610-zim7nond 625 58 other other JJ cord-282610-zim7nond 625 59 members member NNS cord-282610-zim7nond 625 60 of of IN cord-282610-zim7nond 625 61 the the DT cord-282610-zim7nond 625 62 salivary salivary NN cord-282610-zim7nond 625 63 bacteriome bacteriome VBN cord-282610-zim7nond 625 64 Global global JJ cord-282610-zim7nond 625 65 transport transport NN cord-282610-zim7nond 625 66 networks network NNS cord-282610-zim7nond 625 67 and and CC cord-282610-zim7nond 625 68 infectious infectious JJ cord-282610-zim7nond 625 69 disease disease NN cord-282610-zim7nond 626 1 spread spread VBD cord-282610-zim7nond 626 2 The the DT cord-282610-zim7nond 626 3 safety safety NN cord-282610-zim7nond 626 4 and and CC cord-282610-zim7nond 626 5 quality quality NN cord-282610-zim7nond 626 6 of of IN cord-282610-zim7nond 626 7 pork pork NN cord-282610-zim7nond 626 8 and and CC cord-282610-zim7nond 626 9 poultry poultry NN cord-282610-zim7nond 626 10 meat meat NN cord-282610-zim7nond 626 11 imports import NNS cord-282610-zim7nond 626 12 for for IN cord-282610-zim7nond 626 13 the the DT cord-282610-zim7nond 626 14 common common JJ cord-282610-zim7nond 626 15 European european JJ cord-282610-zim7nond 626 16 market market NN cord-282610-zim7nond 626 17 received receive VBN cord-282610-zim7nond 626 18 at at IN cord-282610-zim7nond 626 19 border border NN cord-282610-zim7nond 626 20 inspection inspection NN cord-282610-zim7nond 626 21 post post NN cord-282610-zim7nond 626 22 Hamburg Hamburg NNP cord-282610-zim7nond 626 23 Harbour Harbour NNP cord-282610-zim7nond 626 24 between between IN cord-282610-zim7nond 626 25 Opportunistic opportunistic JJ cord-282610-zim7nond 626 26 pathogens pathogen NNS cord-282610-zim7nond 626 27 enriched enrich VBN cord-282610-zim7nond 626 28 in in IN cord-282610-zim7nond 626 29 showerhead showerhead NN cord-282610-zim7nond 626 30 biofilms biofilm NNS cord-282610-zim7nond 626 31 Human human JJ cord-282610-zim7nond 626 32 pathogens pathogen NNS cord-282610-zim7nond 626 33 abundant abundant JJ cord-282610-zim7nond 626 34 in in IN cord-282610-zim7nond 626 35 the the DT cord-282610-zim7nond 626 36 bacterial bacterial JJ cord-282610-zim7nond 626 37 metagenome metagenome NN cord-282610-zim7nond 626 38 of of IN cord-282610-zim7nond 626 39 cigarettes cigarette NNS cord-282610-zim7nond 627 1 The the DT cord-282610-zim7nond 627 2 status status NN cord-282610-zim7nond 627 3 of of IN cord-282610-zim7nond 627 4 and and CC cord-282610-zim7nond 627 5 future future JJ cord-282610-zim7nond 627 6 research research NN cord-282610-zim7nond 627 7 into into IN cord-282610-zim7nond 627 8 Myalgic Myalgic NNP cord-282610-zim7nond 627 9 Encephalomyelitis Encephalomyelitis NNP cord-282610-zim7nond 627 10 and and CC cord-282610-zim7nond 627 11 Chronic Chronic NNP cord-282610-zim7nond 627 12 Fatigue Fatigue NNP cord-282610-zim7nond 627 13 Syndrome Syndrome NNP cord-282610-zim7nond 627 14 : : : cord-282610-zim7nond 627 15 the the DT cord-282610-zim7nond 627 16 need need NN cord-282610-zim7nond 627 17 of of IN cord-282610-zim7nond 627 18 accurate accurate JJ cord-282610-zim7nond 627 19 diagnosis diagnosis NN cord-282610-zim7nond 627 20 , , , cord-282610-zim7nond 627 21 objective objective JJ cord-282610-zim7nond 627 22 assessment assessment NN cord-282610-zim7nond 627 23 , , , cord-282610-zim7nond 627 24 and and CC cord-282610-zim7nond 627 25 acknowledging acknowledge VBG cord-282610-zim7nond 627 26 biological biological JJ cord-282610-zim7nond 627 27 and and CC cord-282610-zim7nond 627 28 clinical clinical JJ cord-282610-zim7nond 627 29 subgroups subgroup NNS cord-282610-zim7nond 627 30 Chronic Chronic NNP cord-282610-zim7nond 627 31 Lyme Lyme NNP cord-282610-zim7nond 627 32 disease disease NN cord-282610-zim7nond 627 33 Myalgic Myalgic NNP cord-282610-zim7nond 627 34 encephalomyelitis encephalomyelitis NN cord-282610-zim7nond 627 35 / / SYM cord-282610-zim7nond 627 36 chronic chronic JJ cord-282610-zim7nond 627 37 fatigue fatigue NN cord-282610-zim7nond 627 38 syndrome syndrome NN cord-282610-zim7nond 627 39 and and CC cord-282610-zim7nond 627 40 gulf gulf NNP cord-282610-zim7nond 627 41 war war NNP cord-282610-zim7nond 627 42 illness illness NN cord-282610-zim7nond 627 43 patients patient NNS cord-282610-zim7nond 627 44 exhibit exhibit VBP cord-282610-zim7nond 627 45 increased increase VBN cord-282610-zim7nond 627 46 humoral humoral JJ cord-282610-zim7nond 627 47 responses response NNS cord-282610-zim7nond 627 48 to to IN cord-282610-zim7nond 627 49 the the DT cord-282610-zim7nond 627 50 herpesviruses herpesviruses NNP cord-282610-zim7nond 627 51 - - HYPH cord-282610-zim7nond 627 52 encoded encode VBN cord-282610-zim7nond 627 53 dUTPase dUTPase '' cord-282610-zim7nond 627 54 : : : cord-282610-zim7nond 628 1 Implications implication NNS cord-282610-zim7nond 628 2 in in IN cord-282610-zim7nond 628 3 disease disease NN cord-282610-zim7nond 628 4 pathophysiology pathophysiology NN cord-282610-zim7nond 628 5 Chronic Chronic NNP cord-282610-zim7nond 628 6 fatigue fatigue NN cord-282610-zim7nond 628 7 in in IN cord-282610-zim7nond 628 8 Ehlers Ehlers NNP cord-282610-zim7nond 628 9 - - HYPH cord-282610-zim7nond 628 10 Danlos Danlos NNP cord-282610-zim7nond 628 11 syndrome syndrome NN cord-282610-zim7nond 628 12 - - : cord-282610-zim7nond 628 13 Hypermobile Hypermobile NNP cord-282610-zim7nond 628 14 type type NN cord-282610-zim7nond 628 15 Comorbidity comorbidity NN cord-282610-zim7nond 628 16 in in IN cord-282610-zim7nond 628 17 chronic chronic JJ cord-282610-zim7nond 628 18 fatigue fatigue NN cord-282610-zim7nond 628 19 syndrome syndrome NN cord-282610-zim7nond 628 20 / / SYM cord-282610-zim7nond 628 21 myalgic myalgic NNP cord-282610-zim7nond 628 22 encephalomyelitis encephalomyelitis NN cord-282610-zim7nond 628 23 : : : cord-282610-zim7nond 628 24 a a DT cord-282610-zim7nond 628 25 nationwide nationwide JJ cord-282610-zim7nond 628 26 population population NN cord-282610-zim7nond 628 27 - - HYPH cord-282610-zim7nond 628 28 based base VBN cord-282610-zim7nond 628 29 cohort cohort NN cord-282610-zim7nond 628 30 study study NN cord-282610-zim7nond 628 31 Chronic Chronic NNP cord-282610-zim7nond 628 32 fatigue fatigue NN cord-282610-zim7nond 628 33 syndrome syndrome NN cord-282610-zim7nond 628 34 in in IN cord-282610-zim7nond 628 35 patients patient NNS cord-282610-zim7nond 628 36 with with IN cord-282610-zim7nond 628 37 Lyme Lyme NNP cord-282610-zim7nond 628 38 borreliosis borreliosis NN cord-282610-zim7nond 628 39 Infection infection NN cord-282610-zim7nond 628 40 elicited elicit VBD cord-282610-zim7nond 628 41 autoimmunity autoimmunity NN cord-282610-zim7nond 628 42 and and CC cord-282610-zim7nond 628 43 myalgic myalgic JJ cord-282610-zim7nond 628 44 encephalomyelitis encephalomyelitis NN cord-282610-zim7nond 628 45 / / SYM cord-282610-zim7nond 628 46 chronic chronic JJ cord-282610-zim7nond 628 47 fatigue fatigue NN cord-282610-zim7nond 628 48 syndrome syndrome NN cord-282610-zim7nond 628 49 : : : cord-282610-zim7nond 628 50 an an DT cord-282610-zim7nond 628 51 explanatory explanatory JJ cord-282610-zim7nond 628 52 model model NN cord-282610-zim7nond 628 53 Re re NN cord-282610-zim7nond 628 54 - - NN cord-282610-zim7nond 628 55 framing frame VBG cord-282610-zim7nond 628 56 the the DT cord-282610-zim7nond 628 57 theory theory NN cord-282610-zim7nond 628 58 of of IN cord-282610-zim7nond 628 59 autoimmunity autoimmunity NN cord-282610-zim7nond 628 60 in in IN cord-282610-zim7nond 628 61 the the DT cord-282610-zim7nond 628 62 era era NN cord-282610-zim7nond 628 63 of of IN cord-282610-zim7nond 628 64 the the DT cord-282610-zim7nond 628 65 microbiome microbiome NN cord-282610-zim7nond 628 66 : : : cord-282610-zim7nond 628 67 persistent persistent JJ cord-282610-zim7nond 628 68 pathogens pathogen NNS cord-282610-zim7nond 628 69 , , , cord-282610-zim7nond 628 70 autoantibodies autoantibody NNS cord-282610-zim7nond 628 71 , , , cord-282610-zim7nond 628 72 and and CC cord-282610-zim7nond 628 73 molecular molecular JJ cord-282610-zim7nond 628 74 mimicry mimicry NN cord-282610-zim7nond 628 75 Reaction reaction NN cord-282610-zim7nond 628 76 of of IN cord-282610-zim7nond 628 77 amyloid amyloid NN cord-282610-zim7nond 628 78 - - HYPH cord-282610-zim7nond 628 79 β β NN cord-282610-zim7nond 628 80 peptide peptide JJ cord-282610-zim7nond 628 81 antibody antibody NN cord-282610-zim7nond 628 82 with with IN cord-282610-zim7nond 628 83 different different JJ cord-282610-zim7nond 628 84 infectious infectious JJ cord-282610-zim7nond 628 85 agents agent NNS cord-282610-zim7nond 628 86 involved involve VBN cord-282610-zim7nond 628 87 in in IN cord-282610-zim7nond 628 88 alzheimer alzheimer NNP cord-282610-zim7nond 628 89 's 's POS cord-282610-zim7nond 628 90 disease disease NN cord-282610-zim7nond 628 91 Translocation Translocation NNP cord-282610-zim7nond 628 92 of of IN cord-282610-zim7nond 628 93 a a DT cord-282610-zim7nond 628 94 gut gut NN cord-282610-zim7nond 628 95 pathobiont pathobiont NN cord-282610-zim7nond 628 96 drives drive VBZ cord-282610-zim7nond 628 97 autoimmunity autoimmunity NN cord-282610-zim7nond 628 98 in in IN cord-282610-zim7nond 628 99 mice mouse NNS cord-282610-zim7nond 628 100 and and CC cord-282610-zim7nond 628 101 humans human NNS cord-282610-zim7nond 628 102 Manipulation manipulation NN cord-282610-zim7nond 628 103 of of IN cord-282610-zim7nond 628 104 innate innate JJ cord-282610-zim7nond 628 105 and and CC cord-282610-zim7nond 628 106 adaptive adaptive JJ cord-282610-zim7nond 628 107 immunity immunity NN cord-282610-zim7nond 628 108 by by IN cord-282610-zim7nond 628 109 staphylococcal staphylococcal JJ cord-282610-zim7nond 628 110 superantigens superantigens NNP cord-282610-zim7nond 629 1 The the DT cord-282610-zim7nond 629 2 gut gut NN cord-282610-zim7nond 629 3 - - HYPH cord-282610-zim7nond 629 4 brain brain NN cord-282610-zim7nond 629 5 axis axis NN cord-282610-zim7nond 629 6 : : : cord-282610-zim7nond 629 7 interactions interaction NNS cord-282610-zim7nond 629 8 between between IN cord-282610-zim7nond 629 9 enteric enteric JJ cord-282610-zim7nond 629 10 microbiota microbiota NN cord-282610-zim7nond 629 11 , , , cord-282610-zim7nond 629 12 central central JJ cord-282610-zim7nond 629 13 and and CC cord-282610-zim7nond 629 14 enteric enteric JJ cord-282610-zim7nond 629 15 nervous nervous JJ cord-282610-zim7nond 629 16 systems system NNS cord-282610-zim7nond 629 17 Gut gut VBP cord-282610-zim7nond 629 18 feelings feeling NNS cord-282610-zim7nond 629 19 : : : cord-282610-zim7nond 629 20 the the DT cord-282610-zim7nond 629 21 emerging emerge VBG cord-282610-zim7nond 629 22 biology biology NN cord-282610-zim7nond 629 23 of of IN cord-282610-zim7nond 629 24 gut gut NN cord-282610-zim7nond 629 25 - - HYPH cord-282610-zim7nond 629 26 brain brain NN cord-282610-zim7nond 629 27 communication communication NN cord-282610-zim7nond 630 1 The the DT cord-282610-zim7nond 630 2 Alzheimer Alzheimer NNP cord-282610-zim7nond 630 3 's 's POS cord-282610-zim7nond 630 4 disease disease NN cord-282610-zim7nond 630 5 - - HYPH cord-282610-zim7nond 630 6 associated associate VBN cord-282610-zim7nond 630 7 amyloid amyloid NN cord-282610-zim7nond 630 8 beta beta NN cord-282610-zim7nond 630 9 - - HYPH cord-282610-zim7nond 630 10 protein protein NN cord-282610-zim7nond 630 11 is be VBZ cord-282610-zim7nond 630 12 an an DT cord-282610-zim7nond 630 13 antimicrobial antimicrobial JJ cord-282610-zim7nond 630 14 peptide peptide NN cord-282610-zim7nond 630 15 Antimicrobial Antimicrobial NNP cord-282610-zim7nond 630 16 activity activity NN cord-282610-zim7nond 630 17 of of IN cord-282610-zim7nond 630 18 human human JJ cord-282610-zim7nond 630 19 prion prion NN cord-282610-zim7nond 630 20 protein protein NN cord-282610-zim7nond 630 21 is be VBZ cord-282610-zim7nond 630 22 mediated mediate VBN cord-282610-zim7nond 630 23 by by IN cord-282610-zim7nond 630 24 its -PRON- PRP$ cord-282610-zim7nond 630 25 N n CD cord-282610-zim7nond 630 26 - - HYPH cord-282610-zim7nond 630 27 terminal terminal NN cord-282610-zim7nond 630 28 region region NN cord-282610-zim7nond 630 29 Amyloid Amyloid NNP cord-282610-zim7nond 630 30 - - HYPH cord-282610-zim7nond 630 31 β β NN cord-282610-zim7nond 630 32 peptide peptide NN cord-282610-zim7nond 630 33 protects protect VBZ cord-282610-zim7nond 630 34 against against IN cord-282610-zim7nond 630 35 microbial microbial JJ cord-282610-zim7nond 630 36 infection infection NN cord-282610-zim7nond 630 37 in in IN cord-282610-zim7nond 630 38 mouse mouse NN cord-282610-zim7nond 630 39 and and CC cord-282610-zim7nond 630 40 worm worm NN cord-282610-zim7nond 630 41 models model NNS cord-282610-zim7nond 630 42 of of IN cord-282610-zim7nond 630 43 Alzheimer Alzheimer NNP cord-282610-zim7nond 630 44 's 's POS cord-282610-zim7nond 630 45 disease disease NN cord-282610-zim7nond 630 46 Alzheimer Alzheimer NNP cord-282610-zim7nond 630 47 's 's POS cord-282610-zim7nond 630 48 disease disease NN cord-282610-zim7nond 630 49 - - HYPH cord-282610-zim7nond 630 50 associated associate VBN cord-282610-zim7nond 630 51 β β NN cord-282610-zim7nond 630 52 - - HYPH cord-282610-zim7nond 630 53 amyloid amyloid NN cord-282610-zim7nond 630 54 is be VBZ cord-282610-zim7nond 630 55 rapidly rapidly RB cord-282610-zim7nond 630 56 seeded seed VBN cord-282610-zim7nond 630 57 by by IN cord-282610-zim7nond 630 58 herpesviridae herpesviridae NN cord-282610-zim7nond 630 59 to to TO cord-282610-zim7nond 630 60 protect protect VB cord-282610-zim7nond 630 61 against against IN cord-282610-zim7nond 630 62 brain brain NN cord-282610-zim7nond 630 63 infection infection NN cord-282610-zim7nond 630 64 Microbes Microbes NNPS cord-282610-zim7nond 630 65 and and CC cord-282610-zim7nond 630 66 Alzheimer Alzheimer NNP cord-282610-zim7nond 630 67 's 's POS cord-282610-zim7nond 630 68 disease disease NN cord-282610-zim7nond 631 1 Right right JJ cord-282610-zim7nond 631 2 arcuate arcuate JJ cord-282610-zim7nond 631 3 fasciculus fasciculus JJ cord-282610-zim7nond 631 4 abnormality abnormality NN cord-282610-zim7nond 631 5 in in IN cord-282610-zim7nond 631 6 chronic chronic JJ cord-282610-zim7nond 631 7 fatigue fatigue NN cord-282610-zim7nond 631 8 syndrome syndrome NN cord-282610-zim7nond 631 9 BAK1 BAK1 NNP cord-282610-zim7nond 631 10 gene gene NN cord-282610-zim7nond 631 11 variation variation NN cord-282610-zim7nond 631 12 and and CC cord-282610-zim7nond 631 13 abdominal abdominal JJ cord-282610-zim7nond 631 14 aortic aortic JJ cord-282610-zim7nond 631 15 aneurysms aneurysm NNS cord-282610-zim7nond 631 16 Convergence Convergence NNP cord-282610-zim7nond 631 17 of of IN cord-282610-zim7nond 631 18 placenta placenta NN cord-282610-zim7nond 631 19 biology biology NN cord-282610-zim7nond 631 20 and and CC cord-282610-zim7nond 631 21 genetic genetic JJ cord-282610-zim7nond 631 22 risk risk NN cord-282610-zim7nond 631 23 for for IN cord-282610-zim7nond 631 24 schizophrenia schizophrenia NN cord-282610-zim7nond 631 25 Transcription transcription NN cord-282610-zim7nond 631 26 factors factor NNS cord-282610-zim7nond 631 27 operate operate VBP cord-282610-zim7nond 631 28 across across IN cord-282610-zim7nond 631 29 disease disease NN cord-282610-zim7nond 631 30 loci locus NNS cord-282610-zim7nond 631 31 , , , cord-282610-zim7nond 631 32 with with IN cord-282610-zim7nond 631 33 EBNA2 EBNA2 NNP cord-282610-zim7nond 631 34 implicated implicate VBN cord-282610-zim7nond 631 35 in in IN cord-282610-zim7nond 631 36 autoimmunity autoimmunity NN cord-282610-zim7nond 632 1 The the DT cord-282610-zim7nond 632 2 human human JJ cord-282610-zim7nond 632 3 microbiome microbiome NN cord-282610-zim7nond 632 4 and and CC cord-282610-zim7nond 632 5 autoimmunity autoimmunity NN cord-282610-zim7nond 633 1 On on IN cord-282610-zim7nond 633 2 the the DT cord-282610-zim7nond 633 3 translocation translocation NN cord-282610-zim7nond 633 4 of of IN cord-282610-zim7nond 633 5 bacteria bacteria NNS cord-282610-zim7nond 633 6 and and CC cord-282610-zim7nond 633 7 their -PRON- PRP$ cord-282610-zim7nond 633 8 lipopolysaccharides lipopolysaccharide NNS cord-282610-zim7nond 633 9 between between IN cord-282610-zim7nond 633 10 blood blood NN cord-282610-zim7nond 633 11 and and CC cord-282610-zim7nond 633 12 peripheral peripheral JJ cord-282610-zim7nond 633 13 locations location NNS cord-282610-zim7nond 633 14 in in IN cord-282610-zim7nond 633 15 chronic chronic JJ cord-282610-zim7nond 633 16 , , , cord-282610-zim7nond 633 17 inflammatory inflammatory JJ cord-282610-zim7nond 633 18 diseases disease NNS cord-282610-zim7nond 633 19 : : : cord-282610-zim7nond 633 20 the the DT cord-282610-zim7nond 633 21 central central JJ cord-282610-zim7nond 633 22 roles role NNS cord-282610-zim7nond 633 23 of of IN cord-282610-zim7nond 633 24 LPS LPS NNP cord-282610-zim7nond 633 25 and and CC cord-282610-zim7nond 633 26 LPS LPS NNP cord-282610-zim7nond 633 27 - - HYPH cord-282610-zim7nond 633 28 induced induce VBN cord-282610-zim7nond 633 29 cell cell NN cord-282610-zim7nond 633 30 death death NN cord-282610-zim7nond 633 31 HIV HIV NNP cord-282610-zim7nond 633 32 & & CC cord-282610-zim7nond 633 33 immune immune JJ cord-282610-zim7nond 633 34 reconstitution reconstitution NN cord-282610-zim7nond 633 35 inflammatory inflammatory JJ cord-282610-zim7nond 633 36 syndrome syndrome NN cord-282610-zim7nond 633 37 ( ( -LRB- cord-282610-zim7nond 633 38 IRIS IRIS NNP cord-282610-zim7nond 633 39 ) ) -RRB- cord-282610-zim7nond 633 40 Managing manage VBG cord-282610-zim7nond 633 41 cytokine cytokine NN cord-282610-zim7nond 633 42 release release NN cord-282610-zim7nond 633 43 syndrome syndrome NN cord-282610-zim7nond 633 44 associated associate VBN cord-282610-zim7nond 633 45 with with IN cord-282610-zim7nond 633 46 novel novel JJ cord-282610-zim7nond 633 47 T T NNP cord-282610-zim7nond 633 48 cell cell NN cord-282610-zim7nond 633 49 - - HYPH cord-282610-zim7nond 633 50 engaging engage VBG cord-282610-zim7nond 633 51 therapies therapy NNS cord-282610-zim7nond 634 1 The the DT cord-282610-zim7nond 634 2 Jarisch Jarisch NNP cord-282610-zim7nond 634 3 - - HYPH cord-282610-zim7nond 634 4 Herxheimer Herxheimer NNP cord-282610-zim7nond 634 5 reaction reaction NN cord-282610-zim7nond 634 6 in in IN cord-282610-zim7nond 634 7 syphilis syphili NNS cord-282610-zim7nond 634 8 : : : cord-282610-zim7nond 634 9 could could MD cord-282610-zim7nond 634 10 molecular molecular JJ cord-282610-zim7nond 634 11 typing typing NN cord-282610-zim7nond 634 12 help help NN cord-282610-zim7nond 634 13 to to TO cord-282610-zim7nond 634 14 understand understand VB cord-282610-zim7nond 634 15 it -PRON- PRP cord-282610-zim7nond 634 16 better well RBR cord-282610-zim7nond 634 17 ? ? . cord-282610-zim7nond 635 1 Jarisch Jarisch NNP cord-282610-zim7nond 635 2 - - HYPH cord-282610-zim7nond 635 3 herxheimer herxheimer JJ cord-282610-zim7nond 635 4 reaction reaction NN cord-282610-zim7nond 635 5 in in IN cord-282610-zim7nond 635 6 early early JJ cord-282610-zim7nond 635 7 syphilis syphili NNS cord-282610-zim7nond 635 8 Tuberculosis tuberculosis NN cord-282610-zim7nond 635 9 - - HYPH cord-282610-zim7nond 635 10 associated associate VBN cord-282610-zim7nond 635 11 immune immune JJ cord-282610-zim7nond 635 12 reconstitution reconstitution NN cord-282610-zim7nond 635 13 inflammatory inflammatory JJ cord-282610-zim7nond 635 14 syndrome syndrome NN cord-282610-zim7nond 635 15 and and CC cord-282610-zim7nond 635 16 unmasking unmasking NN cord-282610-zim7nond 635 17 of of IN cord-282610-zim7nond 635 18 tuberculosis tuberculosis NN cord-282610-zim7nond 635 19 by by IN cord-282610-zim7nond 635 20 antiretroviral antiretroviral JJ cord-282610-zim7nond 635 21 therapy therapy NN cord-282610-zim7nond 636 1 IeDEA IeDEA NNP cord-282610-zim7nond 637 1 Southern southern JJ cord-282610-zim7nond 637 2 and and CC cord-282610-zim7nond 637 3 Central Central NNP cord-282610-zim7nond 637 4 Africa Africa NNP cord-282610-zim7nond 638 1 Immune immune JJ cord-282610-zim7nond 638 2 reconstitution reconstitution NN cord-282610-zim7nond 638 3 inflammatory inflammatory JJ cord-282610-zim7nond 638 4 syndrome syndrome NN cord-282610-zim7nond 638 5 in in IN cord-282610-zim7nond 638 6 patients patient NNS cord-282610-zim7nond 638 7 starting start VBG cord-282610-zim7nond 638 8 antiretroviral antiretroviral JJ cord-282610-zim7nond 638 9 therapy therapy NN cord-282610-zim7nond 638 10 for for IN cord-282610-zim7nond 638 11 HIV HIV NNP cord-282610-zim7nond 638 12 infection infection NN cord-282610-zim7nond 638 13 : : : cord-282610-zim7nond 638 14 a a DT cord-282610-zim7nond 638 15 systematic systematic JJ cord-282610-zim7nond 638 16 review review NN cord-282610-zim7nond 638 17 and and CC cord-282610-zim7nond 638 18 meta meta NNP cord-282610-zim7nond 638 19 - - HYPH cord-282610-zim7nond 638 20 analysis analysis NN cord-282610-zim7nond 638 21 Immunostimulation Immunostimulation NNP cord-282610-zim7nond 638 22 in in IN cord-282610-zim7nond 638 23 the the DT cord-282610-zim7nond 638 24 treatment treatment NN cord-282610-zim7nond 638 25 for for IN cord-282610-zim7nond 638 26 chronic chronic JJ cord-282610-zim7nond 638 27 fatigue fatigue NN cord-282610-zim7nond 638 28 syndrome syndrome NN cord-282610-zim7nond 638 29 / / SYM cord-282610-zim7nond 638 30 myalgic myalgic JJ cord-282610-zim7nond 638 31 encephalomyelitis encephalomyelitis NN cord-282610-zim7nond 638 32 Immunostimulation Immunostimulation NNP cord-282610-zim7nond 638 33 in in IN cord-282610-zim7nond 638 34 the the DT cord-282610-zim7nond 638 35 era era NN cord-282610-zim7nond 638 36 of of IN cord-282610-zim7nond 638 37 the the DT cord-282610-zim7nond 638 38 metagenome metagenome NNP cord-282610-zim7nond 638 39 Cytokine Cytokine NNP cord-282610-zim7nond 638 40 release release NN cord-282610-zim7nond 638 41 syndrome syndrome NN cord-282610-zim7nond 638 42 Mortality mortality NN cord-282610-zim7nond 638 43 of of IN cord-282610-zim7nond 638 44 people people NNS cord-282610-zim7nond 638 45 with with IN cord-282610-zim7nond 638 46 chronic chronic JJ cord-282610-zim7nond 638 47 fatigue fatigue NN cord-282610-zim7nond 638 48 syndrome syndrome NN cord-282610-zim7nond 638 49 : : : cord-282610-zim7nond 638 50 a a DT cord-282610-zim7nond 638 51 retrospective retrospective JJ cord-282610-zim7nond 638 52 cohort cohort NN cord-282610-zim7nond 638 53 study study NN cord-282610-zim7nond 638 54 in in IN cord-282610-zim7nond 638 55 England England NNP cord-282610-zim7nond 638 56 and and CC cord-282610-zim7nond 638 57 Wales Wales NNP cord-282610-zim7nond 638 58 from from IN cord-282610-zim7nond 638 59 the the DT cord-282610-zim7nond 638 60 South South NNP cord-282610-zim7nond 638 61 London London NNP cord-282610-zim7nond 638 62 and and CC cord-282610-zim7nond 638 63 Maudsley Maudsley NNP cord-282610-zim7nond 638 64 NHS NHS NNP cord-282610-zim7nond 638 65 Foundation Foundation NNP cord-282610-zim7nond 638 66 Trust Trust NNP cord-282610-zim7nond 638 67 Biomedical Biomedical NNP cord-282610-zim7nond 638 68 Research Research NNP cord-282610-zim7nond 638 69 Centre Centre NNP cord-282610-zim7nond 638 70 ( ( -LRB- cord-282610-zim7nond 638 71 SLaM SLaM NNP cord-282610-zim7nond 638 72 BRC BRC NNP cord-282610-zim7nond 638 73 ) ) -RRB- cord-282610-zim7nond 639 1 Clinical Clinical NNP cord-282610-zim7nond 639 2 Record Record NNP cord-282610-zim7nond 639 3 Interactive Interactive NNP cord-282610-zim7nond 639 4 Search Search NNP cord-282610-zim7nond 639 5 ( ( -LRB- cord-282610-zim7nond 639 6 CRIS CRIS NNP cord-282610-zim7nond 639 7 ) ) -RRB- cord-282610-zim7nond 640 1 Register register VB cord-282610-zim7nond 641 1 The the DT cord-282610-zim7nond 641 2 authors author NNS cord-282610-zim7nond 641 3 would would MD cord-282610-zim7nond 641 4 like like VB cord-282610-zim7nond 641 5 to to TO cord-282610-zim7nond 641 6 acknowledge acknowledge VB cord-282610-zim7nond 641 7 Michael Michael NNP cord-282610-zim7nond 641 8 Eason Eason NNP cord-282610-zim7nond 641 9 Kirkpatrick Kirkpatrick NNP cord-282610-zim7nond 641 10 and and CC cord-282610-zim7nond 641 11 Janet Janet NNP cord-282610-zim7nond 641 12 Raty Raty NNP cord-282610-zim7nond 641 13 for for IN cord-282610-zim7nond 641 14 their -PRON- PRP$ cord-282610-zim7nond 641 15 help help NN cord-282610-zim7nond 641 16 with with IN cord-282610-zim7nond 641 17 graphic graphic JJ cord-282610-zim7nond 641 18 design design NN cord-282610-zim7nond 641 19 . . . cord-282610-zim7nond 642 1 They -PRON- PRP cord-282610-zim7nond 642 2 also also RB cord-282610-zim7nond 642 3 thank thank VBP cord-282610-zim7nond 642 4 Sara Sara NNP cord-282610-zim7nond 642 5 Nicole Nicole NNP cord-282610-zim7nond 642 6 Azevedo Azevedo NNP cord-282610-zim7nond 642 7 for for IN cord-282610-zim7nond 642 8 her -PRON- PRP$ cord-282610-zim7nond 642 9 help help NN cord-282610-zim7nond 642 10 with with IN cord-282610-zim7nond 642 11 technical technical JJ cord-282610-zim7nond 642 12 editing editing NN cord-282610-zim7nond 642 13 of of IN cord-282610-zim7nond 642 14 the the DT cord-282610-zim7nond 642 15 manuscript manuscript NN cord-282610-zim7nond 642 16 . . . cord-282610-zim7nond 643 1 The the DT cord-282610-zim7nond 643 2 authors author NNS cord-282610-zim7nond 643 3 declare declare VBP cord-282610-zim7nond 643 4 that that IN cord-282610-zim7nond 643 5 the the DT cord-282610-zim7nond 643 6 research research NN cord-282610-zim7nond 643 7 was be VBD cord-282610-zim7nond 643 8 conducted conduct VBN cord-282610-zim7nond 643 9 in in IN cord-282610-zim7nond 643 10 the the DT cord-282610-zim7nond 643 11 absence absence NN cord-282610-zim7nond 643 12 of of IN cord-282610-zim7nond 643 13 any any DT cord-282610-zim7nond 643 14 commercial commercial JJ cord-282610-zim7nond 643 15 or or CC cord-282610-zim7nond 643 16 financial financial JJ cord-282610-zim7nond 643 17 relationships relationship NNS cord-282610-zim7nond 643 18 that that WDT cord-282610-zim7nond 643 19 could could MD cord-282610-zim7nond 643 20 be be VB cord-282610-zim7nond 643 21 construed construe VBN cord-282610-zim7nond 643 22 as as IN cord-282610-zim7nond 643 23 a a DT cord-282610-zim7nond 643 24 potential potential JJ cord-282610-zim7nond 643 25 conflict conflict NN cord-282610-zim7nond 643 26 of of IN cord-282610-zim7nond 643 27 interest interest NN cord-282610-zim7nond 643 28 . . . cord-282610-zim7nond 644 1 Copyright copyright NN cord-282610-zim7nond 644 2 © © NNP cord-282610-zim7nond 645 1 2018 2018 CD cord-282610-zim7nond 645 2 Proal Proal NNP cord-282610-zim7nond 645 3 and and CC cord-282610-zim7nond 645 4 Marshall Marshall NNP cord-282610-zim7nond 645 5 . . . cord-282610-zim7nond 646 1 This this DT cord-282610-zim7nond 646 2 is be VBZ cord-282610-zim7nond 646 3 an an DT cord-282610-zim7nond 646 4 open open JJ cord-282610-zim7nond 646 5 - - HYPH cord-282610-zim7nond 646 6 access access NN cord-282610-zim7nond 646 7 article article NN cord-282610-zim7nond 646 8 distributed distribute VBN cord-282610-zim7nond 646 9 under under IN cord-282610-zim7nond 646 10 the the DT cord-282610-zim7nond 646 11 terms term NNS cord-282610-zim7nond 646 12 of of IN cord-282610-zim7nond 646 13 the the DT cord-282610-zim7nond 646 14 Creative Creative NNP cord-282610-zim7nond 646 15 Commons Commons NNP cord-282610-zim7nond 646 16 Attribution Attribution NNP cord-282610-zim7nond 646 17 License License NNP cord-282610-zim7nond 646 18 ( ( -LRB- cord-282610-zim7nond 646 19 CC CC NNP cord-282610-zim7nond 646 20 BY BY NNP cord-282610-zim7nond 646 21 ) ) -RRB- cord-282610-zim7nond 646 22 . . . cord-282610-zim7nond 647 1 The the DT cord-282610-zim7nond 647 2 use use NN cord-282610-zim7nond 647 3 , , , cord-282610-zim7nond 647 4 distribution distribution NN cord-282610-zim7nond 647 5 or or CC cord-282610-zim7nond 647 6 reproduction reproduction NN cord-282610-zim7nond 647 7 in in IN cord-282610-zim7nond 647 8 other other JJ cord-282610-zim7nond 647 9 forums forum NNS cord-282610-zim7nond 647 10 is be VBZ cord-282610-zim7nond 647 11 permitted permit VBN cord-282610-zim7nond 647 12 , , , cord-282610-zim7nond 647 13 provided provide VBD cord-282610-zim7nond 647 14 the the DT cord-282610-zim7nond 647 15 original original JJ cord-282610-zim7nond 647 16 author(s author(s NNP cord-282610-zim7nond 647 17 ) ) -RRB- cord-282610-zim7nond 647 18 and and CC cord-282610-zim7nond 647 19 the the DT cord-282610-zim7nond 647 20 copyright copyright NN cord-282610-zim7nond 647 21 owner(s owner(s NNP cord-282610-zim7nond 647 22 ) ) -RRB- cord-282610-zim7nond 647 23 are be VBP cord-282610-zim7nond 647 24 credited credit VBN cord-282610-zim7nond 647 25 and and CC cord-282610-zim7nond 647 26 that that IN cord-282610-zim7nond 647 27 the the DT cord-282610-zim7nond 647 28 original original JJ cord-282610-zim7nond 647 29 publication publication NN cord-282610-zim7nond 647 30 in in IN cord-282610-zim7nond 647 31 this this DT cord-282610-zim7nond 647 32 journal journal NN cord-282610-zim7nond 647 33 is be VBZ cord-282610-zim7nond 647 34 cited cite VBN cord-282610-zim7nond 647 35 , , , cord-282610-zim7nond 647 36 in in IN cord-282610-zim7nond 647 37 accordance accordance NN cord-282610-zim7nond 647 38 with with IN cord-282610-zim7nond 647 39 accepted accepted JJ cord-282610-zim7nond 647 40 academic academic JJ cord-282610-zim7nond 647 41 practice practice NN cord-282610-zim7nond 647 42 . . . cord-282610-zim7nond 648 1 No no DT cord-282610-zim7nond 648 2 use use NN cord-282610-zim7nond 648 3 , , , cord-282610-zim7nond 648 4 distribution distribution NN cord-282610-zim7nond 648 5 or or CC cord-282610-zim7nond 648 6 reproduction reproduction NN cord-282610-zim7nond 648 7 is be VBZ cord-282610-zim7nond 648 8 permitted permit VBN cord-282610-zim7nond 648 9 which which WDT cord-282610-zim7nond 648 10 does do VBZ cord-282610-zim7nond 648 11 not not RB cord-282610-zim7nond 648 12 comply comply VB cord-282610-zim7nond 648 13 with with IN cord-282610-zim7nond 648 14 these these DT cord-282610-zim7nond 648 15 terms term NNS cord-282610-zim7nond 648 16 . . .