id	sid	tid	token	lemma	pos
cord-280549-bsnz24jx	1	1	key	key	JJ
cord-280549-bsnz24jx	1	2	:	:	:
cord-280549-bsnz24jx	1	3	cord-280549-bsnz24jx	cord-280549-bsnz24jx	NN
cord-280549-bsnz24jx	1	4	authors	author	NNS
cord-280549-bsnz24jx	1	5	:	:	:
cord-280549-bsnz24jx	1	6	Fan	Fan	NNP
cord-280549-bsnz24jx	1	7	,	,	,
cord-280549-bsnz24jx	1	8	Ying	Ying	NNP
cord-280549-bsnz24jx	1	9	;	;	:
cord-280549-bsnz24jx	1	10	Sanyal	Sanyal	NNP
cord-280549-bsnz24jx	1	11	,	,	,
cord-280549-bsnz24jx	1	12	Sumana	Sumana	NNP
cord-280549-bsnz24jx	1	13	;	;	:
cord-280549-bsnz24jx	1	14	Bruzzone	Bruzzone	NNP
cord-280549-bsnz24jx	1	15	,	,	,
cord-280549-bsnz24jx	1	16	Roberto	Roberto	NNP
cord-280549-bsnz24jx	1	17	title	title	NN
cord-280549-bsnz24jx	1	18	:	:	:
cord-280549-bsnz24jx	1	19	Breaking	break	VBG
cord-280549-bsnz24jx	1	20	Bad	bad	JJ
cord-280549-bsnz24jx	1	21	:	:	:
cord-280549-bsnz24jx	2	1	How	how	WRB
cord-280549-bsnz24jx	2	2	Viruses	virus	NNS
cord-280549-bsnz24jx	2	3	Subvert	subvert	VBP
cord-280549-bsnz24jx	2	4	the	the	DT
cord-280549-bsnz24jx	2	5	Cell	cell	NN
cord-280549-bsnz24jx	2	6	Cycle	cycle	NN
cord-280549-bsnz24jx	2	7	date	date	NN
cord-280549-bsnz24jx	2	8	:	:	:
cord-280549-bsnz24jx	2	9	2018	2018	CD
cord-280549-bsnz24jx	2	10	-	-	HYPH
cord-280549-bsnz24jx	2	11	11	11	CD
cord-280549-bsnz24jx	2	12	-	-	SYM
cord-280549-bsnz24jx	2	13	19	19	CD
cord-280549-bsnz24jx	2	14	journal	journal	NN
cord-280549-bsnz24jx	2	15	:	:	:
cord-280549-bsnz24jx	3	1	Front	front	JJ
cord-280549-bsnz24jx	3	2	Cell	cell	NN
cord-280549-bsnz24jx	3	3	Infect	infect	VB
cord-280549-bsnz24jx	3	4	Microbiol	Microbiol	NNP
cord-280549-bsnz24jx	3	5	DOI	doi	NN
cord-280549-bsnz24jx	3	6	:	:	:
cord-280549-bsnz24jx	3	7	10.3389	10.3389	CD
cord-280549-bsnz24jx	3	8	/	/	SYM
cord-280549-bsnz24jx	3	9	fcimb.2018.00396	fcimb.2018.00396	CD
cord-280549-bsnz24jx	3	10	sha	sha	NNP
cord-280549-bsnz24jx	3	11	:	:	:
cord-280549-bsnz24jx	4	1	6a0f4aac2dfa46df489b653a06df4b5036e452ea	6a0f4aac2dfa46df489b653a06df4b5036e452ea	CD
cord-280549-bsnz24jx	5	1	doc_id	doc_id	CD
cord-280549-bsnz24jx	5	2	:	:	:
cord-280549-bsnz24jx	5	3	280549	280549	CD
cord-280549-bsnz24jx	5	4	cord_uid	cord_uid	NNS
cord-280549-bsnz24jx	5	5	:	:	:
cord-280549-bsnz24jx	6	1	bsnz24jx	bsnz24jx	NNP
cord-280549-bsnz24jx	6	2	Interactions	Interactions	NNPS
cord-280549-bsnz24jx	6	3	between	between	IN
cord-280549-bsnz24jx	6	4	the	the	DT
cord-280549-bsnz24jx	6	5	host	host	NN
cord-280549-bsnz24jx	6	6	and	and	CC
cord-280549-bsnz24jx	6	7	viruses	virus	NNS
cord-280549-bsnz24jx	6	8	during	during	IN
cord-280549-bsnz24jx	6	9	the	the	DT
cord-280549-bsnz24jx	6	10	course	course	NN
cord-280549-bsnz24jx	6	11	of	of	IN
cord-280549-bsnz24jx	6	12	their	-PRON-	PRP$
cord-280549-bsnz24jx	6	13	co	co	NN
cord-280549-bsnz24jx	6	14	-	-	NN
cord-280549-bsnz24jx	6	15	evolution	evolution	NN
cord-280549-bsnz24jx	6	16	have	have	VBP
cord-280549-bsnz24jx	6	17	not	not	RB
cord-280549-bsnz24jx	6	18	only	only	RB
cord-280549-bsnz24jx	6	19	shaped	shape	VBN
cord-280549-bsnz24jx	6	20	cellular	cellular	JJ
cord-280549-bsnz24jx	6	21	function	function	NN
cord-280549-bsnz24jx	6	22	and	and	CC
cord-280549-bsnz24jx	6	23	the	the	DT
cord-280549-bsnz24jx	6	24	immune	immune	JJ
cord-280549-bsnz24jx	6	25	system	system	NN
cord-280549-bsnz24jx	6	26	,	,	,
cord-280549-bsnz24jx	6	27	but	but	CC
cord-280549-bsnz24jx	6	28	also	also	RB
cord-280549-bsnz24jx	6	29	the	the	DT
cord-280549-bsnz24jx	6	30	counter	counter	JJ
cord-280549-bsnz24jx	6	31	measures	measure	NNS
cord-280549-bsnz24jx	6	32	employed	employ	VBN
cord-280549-bsnz24jx	6	33	by	by	IN
cord-280549-bsnz24jx	6	34	viruses	virus	NNS
cord-280549-bsnz24jx	6	35	.	.	.
cord-280549-bsnz24jx	7	1	Relatively	relatively	RB
cord-280549-bsnz24jx	7	2	small	small	JJ
cord-280549-bsnz24jx	7	3	genomes	genome	NNS
cord-280549-bsnz24jx	7	4	and	and	CC
cord-280549-bsnz24jx	7	5	high	high	JJ
cord-280549-bsnz24jx	7	6	replication	replication	NN
cord-280549-bsnz24jx	7	7	rates	rate	NNS
cord-280549-bsnz24jx	7	8	allow	allow	VBP
cord-280549-bsnz24jx	7	9	viruses	virus	NNS
cord-280549-bsnz24jx	7	10	to	to	TO
cord-280549-bsnz24jx	7	11	accumulate	accumulate	VB
cord-280549-bsnz24jx	7	12	mutations	mutation	NNS
cord-280549-bsnz24jx	7	13	and	and	CC
cord-280549-bsnz24jx	7	14	continuously	continuously	RB
cord-280549-bsnz24jx	7	15	present	present	VB
cord-280549-bsnz24jx	7	16	the	the	DT
cord-280549-bsnz24jx	7	17	host	host	NN
cord-280549-bsnz24jx	7	18	with	with	IN
cord-280549-bsnz24jx	7	19	new	new	JJ
cord-280549-bsnz24jx	7	20	challenges	challenge	NNS
cord-280549-bsnz24jx	7	21	.	.	.
cord-280549-bsnz24jx	8	1	It	-PRON-	PRP
cord-280549-bsnz24jx	8	2	is	be	VBZ
cord-280549-bsnz24jx	8	3	therefore	therefore	RB
cord-280549-bsnz24jx	8	4	,	,	,
cord-280549-bsnz24jx	8	5	no	no	DT
cord-280549-bsnz24jx	8	6	surprise	surprise	NN
cord-280549-bsnz24jx	8	7	that	that	IN
cord-280549-bsnz24jx	8	8	they	-PRON-	PRP
cord-280549-bsnz24jx	8	9	either	either	CC
cord-280549-bsnz24jx	8	10	escape	escape	VBP
cord-280549-bsnz24jx	8	11	detection	detection	NN
cord-280549-bsnz24jx	8	12	or	or	CC
cord-280549-bsnz24jx	8	13	modulate	modulate	VB
cord-280549-bsnz24jx	8	14	host	host	NN
cord-280549-bsnz24jx	8	15	physiology	physiology	NN
cord-280549-bsnz24jx	8	16	,	,	,
cord-280549-bsnz24jx	8	17	often	often	RB
cord-280549-bsnz24jx	8	18	by	by	IN
cord-280549-bsnz24jx	8	19	redirecting	redirect	VBG
cord-280549-bsnz24jx	8	20	normal	normal	JJ
cord-280549-bsnz24jx	8	21	cellular	cellular	JJ
cord-280549-bsnz24jx	8	22	pathways	pathway	NNS
cord-280549-bsnz24jx	8	23	to	to	IN
cord-280549-bsnz24jx	8	24	their	-PRON-	PRP$
cord-280549-bsnz24jx	8	25	own	own	JJ
cord-280549-bsnz24jx	8	26	advantage	advantage	NN
cord-280549-bsnz24jx	8	27	.	.	.
cord-280549-bsnz24jx	9	1	Viruses	virus	NNS
cord-280549-bsnz24jx	9	2	utilize	utilize	VBP
cord-280549-bsnz24jx	9	3	a	a	DT
cord-280549-bsnz24jx	9	4	diverse	diverse	JJ
cord-280549-bsnz24jx	9	5	array	array	NN
cord-280549-bsnz24jx	9	6	of	of	IN
cord-280549-bsnz24jx	9	7	strategies	strategy	NNS
cord-280549-bsnz24jx	9	8	and	and	CC
cord-280549-bsnz24jx	9	9	molecular	molecular	JJ
cord-280549-bsnz24jx	9	10	targets	target	NNS
cord-280549-bsnz24jx	9	11	to	to	TO
cord-280549-bsnz24jx	9	12	subvert	subvert	VB
cord-280549-bsnz24jx	9	13	host	host	NN
cord-280549-bsnz24jx	9	14	cellular	cellular	JJ
cord-280549-bsnz24jx	9	15	processes	process	NNS
cord-280549-bsnz24jx	9	16	,	,	,
cord-280549-bsnz24jx	9	17	while	while	IN
cord-280549-bsnz24jx	9	18	evading	evade	VBG
cord-280549-bsnz24jx	9	19	detection	detection	NN
cord-280549-bsnz24jx	9	20	.	.	.
cord-280549-bsnz24jx	10	1	These	these	DT
cord-280549-bsnz24jx	10	2	include	include	VBP
cord-280549-bsnz24jx	10	3	cell	cell	NN
cord-280549-bsnz24jx	10	4	-	-	HYPH
cord-280549-bsnz24jx	10	5	cycle	cycle	NN
cord-280549-bsnz24jx	10	6	regulation	regulation	NN
cord-280549-bsnz24jx	10	7	,	,	,
cord-280549-bsnz24jx	10	8	major	major	JJ
cord-280549-bsnz24jx	10	9	histocompatibility	histocompatibility	NN
cord-280549-bsnz24jx	10	10	complex	complex	NN
cord-280549-bsnz24jx	10	11	-	-	HYPH
cord-280549-bsnz24jx	10	12	restricted	restrict	VBN
cord-280549-bsnz24jx	10	13	antigen	antigen	NN
cord-280549-bsnz24jx	10	14	presentation	presentation	NN
cord-280549-bsnz24jx	10	15	,	,	,
cord-280549-bsnz24jx	10	16	intracellular	intracellular	JJ
cord-280549-bsnz24jx	10	17	protein	protein	NN
cord-280549-bsnz24jx	10	18	transport	transport	NN
cord-280549-bsnz24jx	10	19	,	,	,
cord-280549-bsnz24jx	10	20	apoptosis	apoptosis	NN
cord-280549-bsnz24jx	10	21	,	,	,
cord-280549-bsnz24jx	10	22	cytokine	cytokine	NN
cord-280549-bsnz24jx	10	23	-	-	HYPH
cord-280549-bsnz24jx	10	24	mediated	mediate	VBN
cord-280549-bsnz24jx	10	25	signaling	signaling	NN
cord-280549-bsnz24jx	10	26	,	,	,
cord-280549-bsnz24jx	10	27	and	and	CC
cord-280549-bsnz24jx	10	28	humoral	humoral	JJ
cord-280549-bsnz24jx	10	29	immune	immune	JJ
cord-280549-bsnz24jx	10	30	responses	response	NNS
cord-280549-bsnz24jx	10	31	.	.	.
cord-280549-bsnz24jx	11	1	Moreover	moreover	RB
cord-280549-bsnz24jx	11	2	,	,	,
cord-280549-bsnz24jx	11	3	viruses	virus	NNS
cord-280549-bsnz24jx	11	4	routinely	routinely	RB
cord-280549-bsnz24jx	11	5	manipulate	manipulate	VBP
cord-280549-bsnz24jx	11	6	the	the	DT
cord-280549-bsnz24jx	11	7	host	host	NN
cord-280549-bsnz24jx	11	8	cell	cell	NN
cord-280549-bsnz24jx	11	9	cycle	cycle	NN
cord-280549-bsnz24jx	11	10	to	to	TO
cord-280549-bsnz24jx	11	11	create	create	VB
cord-280549-bsnz24jx	11	12	a	a	DT
cord-280549-bsnz24jx	11	13	favorable	favorable	JJ
cord-280549-bsnz24jx	11	14	environment	environment	NN
cord-280549-bsnz24jx	11	15	for	for	IN
cord-280549-bsnz24jx	11	16	replication	replication	NN
cord-280549-bsnz24jx	11	17	,	,	,
cord-280549-bsnz24jx	11	18	largely	largely	RB
cord-280549-bsnz24jx	11	19	by	by	IN
cord-280549-bsnz24jx	11	20	deregulating	deregulate	VBG
cord-280549-bsnz24jx	11	21	cell	cell	NN
cord-280549-bsnz24jx	11	22	cycle	cycle	NN
cord-280549-bsnz24jx	11	23	checkpoints	checkpoint	NNS
cord-280549-bsnz24jx	11	24	.	.	.
cord-280549-bsnz24jx	12	1	This	this	DT
cord-280549-bsnz24jx	12	2	review	review	NN
cord-280549-bsnz24jx	12	3	focuses	focus	VBZ
cord-280549-bsnz24jx	12	4	on	on	IN
cord-280549-bsnz24jx	12	5	our	-PRON-	PRP$
cord-280549-bsnz24jx	12	6	current	current	JJ
cord-280549-bsnz24jx	12	7	understanding	understanding	NN
cord-280549-bsnz24jx	12	8	of	of	IN
cord-280549-bsnz24jx	12	9	the	the	DT
cord-280549-bsnz24jx	12	10	molecular	molecular	JJ
cord-280549-bsnz24jx	12	11	aspects	aspect	NNS
cord-280549-bsnz24jx	12	12	of	of	IN
cord-280549-bsnz24jx	12	13	cell	cell	NN
cord-280549-bsnz24jx	12	14	cycle	cycle	NN
cord-280549-bsnz24jx	12	15	regulation	regulation	NN
cord-280549-bsnz24jx	12	16	that	that	WDT
cord-280549-bsnz24jx	12	17	are	be	VBP
cord-280549-bsnz24jx	12	18	often	often	RB
cord-280549-bsnz24jx	12	19	targeted	target	VBN
cord-280549-bsnz24jx	12	20	by	by	IN
cord-280549-bsnz24jx	12	21	viruses	virus	NNS
cord-280549-bsnz24jx	12	22	.	.	.
cord-280549-bsnz24jx	13	1	Further	further	JJ
cord-280549-bsnz24jx	13	2	study	study	NN
cord-280549-bsnz24jx	13	3	of	of	IN
cord-280549-bsnz24jx	13	4	their	-PRON-	PRP$
cord-280549-bsnz24jx	13	5	interactions	interaction	NNS
cord-280549-bsnz24jx	13	6	should	should	MD
cord-280549-bsnz24jx	13	7	provide	provide	VB
cord-280549-bsnz24jx	13	8	fundamental	fundamental	JJ
cord-280549-bsnz24jx	13	9	insights	insight	NNS
cord-280549-bsnz24jx	13	10	into	into	IN
cord-280549-bsnz24jx	13	11	cell	cell	NN
cord-280549-bsnz24jx	13	12	cycle	cycle	NN
cord-280549-bsnz24jx	13	13	regulation	regulation	NN
cord-280549-bsnz24jx	13	14	and	and	CC
cord-280549-bsnz24jx	13	15	improve	improve	VB
cord-280549-bsnz24jx	13	16	our	-PRON-	PRP$
cord-280549-bsnz24jx	13	17	ability	ability	NN
cord-280549-bsnz24jx	13	18	to	to	TO
cord-280549-bsnz24jx	13	19	exploit	exploit	VB
cord-280549-bsnz24jx	13	20	these	these	DT
cord-280549-bsnz24jx	13	21	viruses	virus	NNS
cord-280549-bsnz24jx	13	22	.	.	.
cord-280549-bsnz24jx	14	1	The	the	DT
cord-280549-bsnz24jx	14	2	study	study	NN
cord-280549-bsnz24jx	14	3	of	of	IN
cord-280549-bsnz24jx	14	4	host	host	NN
cord-280549-bsnz24jx	14	5	-	-	HYPH
cord-280549-bsnz24jx	14	6	pathogen	pathogen	NN
cord-280549-bsnz24jx	14	7	interaction	interaction	NN
cord-280549-bsnz24jx	14	8	and	and	CC
cord-280549-bsnz24jx	14	9	the	the	DT
cord-280549-bsnz24jx	14	10	search	search	NN
cord-280549-bsnz24jx	14	11	for	for	IN
cord-280549-bsnz24jx	14	12	host	host	NN
cord-280549-bsnz24jx	14	13	factors	factor	NNS
cord-280549-bsnz24jx	14	14	that	that	WDT
cord-280549-bsnz24jx	14	15	are	be	VBP
cord-280549-bsnz24jx	14	16	crucial	crucial	JJ
cord-280549-bsnz24jx	14	17	for	for	IN
cord-280549-bsnz24jx	14	18	virus	virus	NN
cord-280549-bsnz24jx	14	19	life	life	NN
cord-280549-bsnz24jx	14	20	cycle	cycle	NN
cord-280549-bsnz24jx	14	21	is	be	VBZ
cord-280549-bsnz24jx	14	22	critical	critical	JJ
cord-280549-bsnz24jx	14	23	to	to	IN
cord-280549-bsnz24jx	14	24	the	the	DT
cord-280549-bsnz24jx	14	25	understanding	understanding	NN
cord-280549-bsnz24jx	14	26	of	of	IN
cord-280549-bsnz24jx	14	27	viral	viral	JJ
cord-280549-bsnz24jx	14	28	pathogenesis	pathogenesis	NN
cord-280549-bsnz24jx	14	29	,	,	,
cord-280549-bsnz24jx	14	30	and	and	CC
cord-280549-bsnz24jx	14	31	may	may	MD
cord-280549-bsnz24jx	14	32	shed	shed	VB
cord-280549-bsnz24jx	14	33	light	light	NN
cord-280549-bsnz24jx	14	34	on	on	IN
cord-280549-bsnz24jx	14	35	the	the	DT
cord-280549-bsnz24jx	14	36	development	development	NN
cord-280549-bsnz24jx	14	37	of	of	IN
cord-280549-bsnz24jx	14	38	therapeutic	therapeutic	JJ
cord-280549-bsnz24jx	14	39	approaches	approach	NNS
cord-280549-bsnz24jx	14	40	.	.	.
cord-280549-bsnz24jx	15	1	Viruses	virus	NNS
cord-280549-bsnz24jx	15	2	are	be	VBP
cord-280549-bsnz24jx	15	3	obligate	obligate	VBN
cord-280549-bsnz24jx	15	4	intracellular	intracellular	JJ
cord-280549-bsnz24jx	15	5	parasites	parasite	NNS
cord-280549-bsnz24jx	15	6	that	that	WDT
cord-280549-bsnz24jx	15	7	constantly	constantly	RB
cord-280549-bsnz24jx	15	8	evolve	evolve	VBP
cord-280549-bsnz24jx	15	9	strategies	strategy	NNS
cord-280549-bsnz24jx	15	10	to	to	TO
cord-280549-bsnz24jx	15	11	subvert	subvert	VB
cord-280549-bsnz24jx	15	12	their	-PRON-	PRP$
cord-280549-bsnz24jx	15	13	host	host	NN
cord-280549-bsnz24jx	15	14	cellular	cellular	JJ
cord-280549-bsnz24jx	15	15	environment	environment	NN
cord-280549-bsnz24jx	15	16	.	.	.
cord-280549-bsnz24jx	16	1	As	as	IN
cord-280549-bsnz24jx	16	2	survival	survival	NN
cord-280549-bsnz24jx	16	3	of	of	IN
cord-280549-bsnz24jx	16	4	viruses	virus	NNS
cord-280549-bsnz24jx	16	5	depend	depend	VBP
cord-280549-bsnz24jx	16	6	on	on	IN
cord-280549-bsnz24jx	16	7	the	the	DT
cord-280549-bsnz24jx	16	8	ability	ability	NN
cord-280549-bsnz24jx	16	9	to	to	TO
cord-280549-bsnz24jx	16	10	replicate	replicate	VB
cord-280549-bsnz24jx	16	11	in	in	IN
cord-280549-bsnz24jx	16	12	living	live	VBG
cord-280549-bsnz24jx	16	13	organisms	organism	NNS
cord-280549-bsnz24jx	16	14	,	,	,
cord-280549-bsnz24jx	16	15	it	-PRON-	PRP
cord-280549-bsnz24jx	16	16	is	be	VBZ
cord-280549-bsnz24jx	16	17	not	not	RB
cord-280549-bsnz24jx	16	18	surprising	surprising	JJ
cord-280549-bsnz24jx	16	19	that	that	IN
cord-280549-bsnz24jx	16	20	they	-PRON-	PRP
cord-280549-bsnz24jx	16	21	are	be	VBP
cord-280549-bsnz24jx	16	22	able	able	JJ
cord-280549-bsnz24jx	16	23	to	to	TO
cord-280549-bsnz24jx	16	24	arrest	arrest	VB
cord-280549-bsnz24jx	16	25	or	or	CC
cord-280549-bsnz24jx	16	26	promote	promote	VB
cord-280549-bsnz24jx	16	27	cell	cell	NN
cord-280549-bsnz24jx	16	28	cycle	cycle	NN
cord-280549-bsnz24jx	16	29	progression	progression	NN
cord-280549-bsnz24jx	16	30	,	,	,
cord-280549-bsnz24jx	16	31	depending	depend	VBG
cord-280549-bsnz24jx	16	32	on	on	IN
cord-280549-bsnz24jx	16	33	the	the	DT
cord-280549-bsnz24jx	16	34	purpose	purpose	NN
cord-280549-bsnz24jx	16	35	,	,	,
cord-280549-bsnz24jx	16	36	to	to	IN
cord-280549-bsnz24jx	16	37	their	-PRON-	PRP$
cord-280549-bsnz24jx	16	38	advantage	advantage	NN
cord-280549-bsnz24jx	16	39	.	.	.
cord-280549-bsnz24jx	17	1	Viruses	virus	NNS
cord-280549-bsnz24jx	17	2	that	that	WDT
cord-280549-bsnz24jx	17	3	are	be	VBP
cord-280549-bsnz24jx	17	4	associated	associate	VBN
cord-280549-bsnz24jx	17	5	with	with	IN
cord-280549-bsnz24jx	17	6	malignancies	malignancy	NNS
cord-280549-bsnz24jx	17	7	,	,	,
cord-280549-bsnz24jx	17	8	such	such	JJ
cord-280549-bsnz24jx	17	9	as	as	IN
cord-280549-bsnz24jx	17	10	human	human	JJ
cord-280549-bsnz24jx	17	11	T	t	NN
cord-280549-bsnz24jx	17	12	-	-	HYPH
cord-280549-bsnz24jx	17	13	cell	cell	NN
cord-280549-bsnz24jx	17	14	leukemia	leukemia	NN
cord-280549-bsnz24jx	17	15	virus	virus	NN
cord-280549-bsnz24jx	17	16	type	type	NN
cord-280549-bsnz24jx	17	17	I	-PRON-	PRP
cord-280549-bsnz24jx	17	18	(	(	-LRB-
cord-280549-bsnz24jx	17	19	HTLV-1	HTLV-1	NNP
cord-280549-bsnz24jx	17	20	)	)	-RRB-
cord-280549-bsnz24jx	17	21	,	,	,
cord-280549-bsnz24jx	17	22	Epstein	Epstein	NNP
cord-280549-bsnz24jx	17	23	-	-	HYPH
cord-280549-bsnz24jx	17	24	Barr	Barr	NNP
cord-280549-bsnz24jx	17	25	virus	virus	NN
cord-280549-bsnz24jx	17	26	(	(	-LRB-
cord-280549-bsnz24jx	17	27	EBV	EBV	NNP
cord-280549-bsnz24jx	17	28	)	)	-RRB-
cord-280549-bsnz24jx	17	29	,	,	,
cord-280549-bsnz24jx	17	30	human	human	JJ
cord-280549-bsnz24jx	17	31	papilloma	papilloma	NN
cord-280549-bsnz24jx	17	32	virus	virus	NN
cord-280549-bsnz24jx	17	33	(	(	-LRB-
cord-280549-bsnz24jx	17	34	HPV	HPV	NNP
cord-280549-bsnz24jx	17	35	)	)	-RRB-
cord-280549-bsnz24jx	17	36	,	,	,
cord-280549-bsnz24jx	17	37	and	and	CC
cord-280549-bsnz24jx	17	38	Kaposi	Kaposi	NNP
cord-280549-bsnz24jx	17	39	's	's	POS
cord-280549-bsnz24jx	17	40	sarcoma	sarcoma	NN
cord-280549-bsnz24jx	17	41	-	-	HYPH
cord-280549-bsnz24jx	17	42	associated	associate	VBN
cord-280549-bsnz24jx	17	43	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	17	44	(	(	-LRB-
cord-280549-bsnz24jx	17	45	KSHV	KSHV	NNP
cord-280549-bsnz24jx	17	46	)	)	-RRB-
cord-280549-bsnz24jx	17	47	,	,	,
cord-280549-bsnz24jx	17	48	have	have	VBP
cord-280549-bsnz24jx	17	49	long	long	RB
cord-280549-bsnz24jx	17	50	been	be	VBN
cord-280549-bsnz24jx	17	51	known	know	VBN
cord-280549-bsnz24jx	17	52	to	to	TO
cord-280549-bsnz24jx	17	53	antagonize	antagonize	VB
cord-280549-bsnz24jx	17	54	cell	cell	NN
cord-280549-bsnz24jx	17	55	cycle	cycle	NN
cord-280549-bsnz24jx	17	56	checkpoints	checkpoint	NNS
cord-280549-bsnz24jx	17	57	for	for	IN
cord-280549-bsnz24jx	17	58	neoplastic	neoplastic	JJ
cord-280549-bsnz24jx	17	59	transformation	transformation	NN
cord-280549-bsnz24jx	17	60	of	of	IN
cord-280549-bsnz24jx	17	61	infected	infected	JJ
cord-280549-bsnz24jx	17	62	cells	cell	NNS
cord-280549-bsnz24jx	17	63	(	(	-LRB-
cord-280549-bsnz24jx	17	64	Dyson	Dyson	NNP
cord-280549-bsnz24jx	17	65	et	et	NNP
cord-280549-bsnz24jx	17	66	al	al	NNP
cord-280549-bsnz24jx	17	67	.	.	.
cord-280549-bsnz24jx	18	1	,	,	,
cord-280549-bsnz24jx	18	2	1989	1989	CD
cord-280549-bsnz24jx	18	3	;	;	:
cord-280549-bsnz24jx	18	4	Moore	Moore	NNP
cord-280549-bsnz24jx	18	5	and	and	CC
cord-280549-bsnz24jx	18	6	Chang	Chang	NNP
cord-280549-bsnz24jx	18	7	,	,	,
cord-280549-bsnz24jx	18	8	1998	1998	CD
cord-280549-bsnz24jx	18	9	;	;	:
cord-280549-bsnz24jx	18	10	Knight	Knight	NNP
cord-280549-bsnz24jx	18	11	and	and	CC
cord-280549-bsnz24jx	18	12	Robertson	Robertson	NNP
cord-280549-bsnz24jx	18	13	,	,	,
cord-280549-bsnz24jx	18	14	2004	2004	CD
cord-280549-bsnz24jx	18	15	;	;	:
cord-280549-bsnz24jx	18	16	Iwanaga	Iwanaga	NNP
cord-280549-bsnz24jx	18	17	et	et	NNP
cord-280549-bsnz24jx	18	18	al	al	NNP
cord-280549-bsnz24jx	18	19	.	.	NNP
cord-280549-bsnz24jx	18	20	,	,	,
cord-280549-bsnz24jx	18	21	2008	2008	CD
cord-280549-bsnz24jx	18	22	)	)	-RRB-
cord-280549-bsnz24jx	18	23	.	.	.
cord-280549-bsnz24jx	19	1	Thus	thus	RB
cord-280549-bsnz24jx	19	2	,	,	,
cord-280549-bsnz24jx	19	3	Simian	simian	JJ
cord-280549-bsnz24jx	19	4	virus	virus	NN
cord-280549-bsnz24jx	19	5	40	40	CD
cord-280549-bsnz24jx	19	6	(	(	-LRB-
cord-280549-bsnz24jx	19	7	SV40	SV40	NNP
cord-280549-bsnz24jx	19	8	)	)	-RRB-
cord-280549-bsnz24jx	19	9	and	and	CC
cord-280549-bsnz24jx	19	10	HPV	HPV	NNP
cord-280549-bsnz24jx	19	11	promote	promote	VBP
cord-280549-bsnz24jx	19	12	entry	entry	NN
cord-280549-bsnz24jx	19	13	of	of	IN
cord-280549-bsnz24jx	19	14	host	host	NN
cord-280549-bsnz24jx	19	15	cell	cell	NN
cord-280549-bsnz24jx	19	16	cycle	cycle	NN
cord-280549-bsnz24jx	19	17	into	into	IN
cord-280549-bsnz24jx	19	18	the	the	DT
cord-280549-bsnz24jx	19	19	S	S	NNP
cord-280549-bsnz24jx	19	20	phase	phase	NN
cord-280549-bsnz24jx	19	21	as	as	IN
cord-280549-bsnz24jx	19	22	viral	viral	JJ
cord-280549-bsnz24jx	19	23	DNA	dna	NN
cord-280549-bsnz24jx	19	24	replication	replication	NN
cord-280549-bsnz24jx	19	25	depends	depend	VBZ
cord-280549-bsnz24jx	19	26	on	on	IN
cord-280549-bsnz24jx	19	27	the	the	DT
cord-280549-bsnz24jx	19	28	host	host	NN
cord-280549-bsnz24jx	19	29	DNA	dna	NN
cord-280549-bsnz24jx	19	30	replication	replication	NN
cord-280549-bsnz24jx	19	31	machinery	machinery	NN
cord-280549-bsnz24jx	19	32	(	(	-LRB-
cord-280549-bsnz24jx	19	33	Lehman	Lehman	NNP
cord-280549-bsnz24jx	19	34	et	et	NNP
cord-280549-bsnz24jx	19	35	al	al	NNP
cord-280549-bsnz24jx	19	36	.	.	NNP
cord-280549-bsnz24jx	19	37	,	,	,
cord-280549-bsnz24jx	19	38	2000	2000	CD
cord-280549-bsnz24jx	19	39	;	;	:
cord-280549-bsnz24jx	19	40	Banerjee	Banerjee	NNP
cord-280549-bsnz24jx	19	41	et	et	NNP
cord-280549-bsnz24jx	19	42	al	al	NNP
cord-280549-bsnz24jx	19	43	.	.	NNP
cord-280549-bsnz24jx	19	44	,	,	,
cord-280549-bsnz24jx	19	45	2011	2011	CD
cord-280549-bsnz24jx	19	46	)	)	-RRB-
cord-280549-bsnz24jx	19	47	.	.	.
cord-280549-bsnz24jx	20	1	In	in	IN
cord-280549-bsnz24jx	20	2	contrast	contrast	NN
cord-280549-bsnz24jx	20	3	,	,	,
cord-280549-bsnz24jx	20	4	human	human	JJ
cord-280549-bsnz24jx	20	5	immunodeficiency	immunodeficiency	NN
cord-280549-bsnz24jx	20	6	virus	virus	NN
cord-280549-bsnz24jx	20	7	type	type	NN
cord-280549-bsnz24jx	20	8	1	1	CD
cord-280549-bsnz24jx	20	9	(	(	-LRB-
cord-280549-bsnz24jx	20	10	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	20	11	)	)	-RRB-
cord-280549-bsnz24jx	20	12	infection	infection	NN
cord-280549-bsnz24jx	20	13	of	of	IN
cord-280549-bsnz24jx	20	14	T	t	NN
cord-280549-bsnz24jx	20	15	lymphocytes	lymphocyte	NNS
cord-280549-bsnz24jx	20	16	results	result	VBZ
cord-280549-bsnz24jx	20	17	in	in	IN
cord-280549-bsnz24jx	20	18	a	a	DT
cord-280549-bsnz24jx	20	19	cell	cell	NN
cord-280549-bsnz24jx	20	20	cycle	cycle	NN
cord-280549-bsnz24jx	20	21	arrest	arrest	NN
cord-280549-bsnz24jx	20	22	in	in	IN
cord-280549-bsnz24jx	20	23	G2	G2	NNP
cord-280549-bsnz24jx	20	24	,	,	,
cord-280549-bsnz24jx	20	25	suggesting	suggest	VBG
cord-280549-bsnz24jx	20	26	that	that	IN
cord-280549-bsnz24jx	20	27	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	20	28	may	may	MD
cord-280549-bsnz24jx	20	29	disrupt	disrupt	VB
cord-280549-bsnz24jx	20	30	T	t	NN
cord-280549-bsnz24jx	20	31	-	-	HYPH
cord-280549-bsnz24jx	20	32	cell	cell	NN
cord-280549-bsnz24jx	20	33	-	-	HYPH
cord-280549-bsnz24jx	20	34	mediated	mediate	VBN
cord-280549-bsnz24jx	20	35	immune	immune	JJ
cord-280549-bsnz24jx	20	36	response	response	NN
cord-280549-bsnz24jx	20	37	by	by	IN
cord-280549-bsnz24jx	20	38	preventing	prevent	VBG
cord-280549-bsnz24jx	20	39	its	-PRON-	PRP$
cord-280549-bsnz24jx	20	40	clonal	clonal	JJ
cord-280549-bsnz24jx	20	41	expansion	expansion	NN
cord-280549-bsnz24jx	20	42	(	(	-LRB-
cord-280549-bsnz24jx	20	43	Zimmerman	Zimmerman	NNP
cord-280549-bsnz24jx	20	44	et	et	NNP
cord-280549-bsnz24jx	20	45	al	al	NNP
cord-280549-bsnz24jx	20	46	.	.	NNP
cord-280549-bsnz24jx	20	47	,	,	,
cord-280549-bsnz24jx	20	48	2006	2006	CD
cord-280549-bsnz24jx	20	49	)	)	-RRB-
cord-280549-bsnz24jx	20	50	.	.	.
cord-280549-bsnz24jx	21	1	The	the	DT
cord-280549-bsnz24jx	21	2	avian	avian	JJ
cord-280549-bsnz24jx	21	3	coronavirus	coronavirus	NN
cord-280549-bsnz24jx	21	4	infectious	infectious	JJ
cord-280549-bsnz24jx	21	5	bronchitis	bronchitis	NN
cord-280549-bsnz24jx	21	6	virus	virus	NN
cord-280549-bsnz24jx	21	7	(	(	-LRB-
cord-280549-bsnz24jx	21	8	IBV	IBV	NNP
cord-280549-bsnz24jx	21	9	)	)	-RRB-
cord-280549-bsnz24jx	21	10	also	also	RB
cord-280549-bsnz24jx	21	11	promotes	promote	VBZ
cord-280549-bsnz24jx	21	12	favorable	favorable	JJ
cord-280549-bsnz24jx	21	13	conditions	condition	NNS
cord-280549-bsnz24jx	21	14	for	for	IN
cord-280549-bsnz24jx	21	15	viral	viral	JJ
cord-280549-bsnz24jx	21	16	protein	protein	NN
cord-280549-bsnz24jx	21	17	synthesis	synthesis	NN
cord-280549-bsnz24jx	21	18	and	and	CC
cord-280549-bsnz24jx	21	19	,	,	,
cord-280549-bsnz24jx	21	20	hence	hence	RB
cord-280549-bsnz24jx	21	21	,	,	,
cord-280549-bsnz24jx	21	22	progeny	progeny	JJ
cord-280549-bsnz24jx	21	23	virus	virus	NN
cord-280549-bsnz24jx	21	24	production	production	NN
cord-280549-bsnz24jx	21	25	,	,	,
cord-280549-bsnz24jx	21	26	by	by	IN
cord-280549-bsnz24jx	21	27	inducing	induce	VBG
cord-280549-bsnz24jx	21	28	cell	cell	NN
cord-280549-bsnz24jx	21	29	cycle	cycle	NN
cord-280549-bsnz24jx	21	30	G2	G2	NNP
cord-280549-bsnz24jx	21	31	/	/	SYM
cord-280549-bsnz24jx	21	32	M	M	NNP
cord-280549-bsnz24jx	21	33	phase	phase	NN
cord-280549-bsnz24jx	21	34	arrest	arrest	NN
cord-280549-bsnz24jx	21	35	of	of	IN
cord-280549-bsnz24jx	21	36	virusinfected	virusinfecte	VBN
cord-280549-bsnz24jx	21	37	cells	cell	NNS
cord-280549-bsnz24jx	21	38	(	(	-LRB-
cord-280549-bsnz24jx	21	39	Dove	Dove	NNP
cord-280549-bsnz24jx	21	40	et	et	FW
cord-280549-bsnz24jx	21	41	al	al	NNP
cord-280549-bsnz24jx	21	42	.	.	NNP
cord-280549-bsnz24jx	21	43	,	,	,
cord-280549-bsnz24jx	21	44	2006	2006	CD
cord-280549-bsnz24jx	21	45	)	)	-RRB-
cord-280549-bsnz24jx	21	46	.	.	.
cord-280549-bsnz24jx	22	1	The	the	DT
cord-280549-bsnz24jx	22	2	investigation	investigation	NN
cord-280549-bsnz24jx	22	3	of	of	IN
cord-280549-bsnz24jx	22	4	mechanisms	mechanism	NNS
cord-280549-bsnz24jx	22	5	viruses	virus	NNS
cord-280549-bsnz24jx	22	6	employ	employ	VBP
cord-280549-bsnz24jx	22	7	to	to	TO
cord-280549-bsnz24jx	22	8	hijack	hijack	VB
cord-280549-bsnz24jx	22	9	host	host	NN
cord-280549-bsnz24jx	22	10	cell	cell	NN
cord-280549-bsnz24jx	22	11	cycle	cycle	NN
cord-280549-bsnz24jx	22	12	is	be	VBZ
cord-280549-bsnz24jx	22	13	,	,	,
cord-280549-bsnz24jx	22	14	therefore	therefore	RB
cord-280549-bsnz24jx	22	15	,	,	,
cord-280549-bsnz24jx	22	16	of	of	IN
cord-280549-bsnz24jx	22	17	significance	significance	NN
cord-280549-bsnz24jx	22	18	not	not	RB
cord-280549-bsnz24jx	22	19	only	only	RB
cord-280549-bsnz24jx	22	20	for	for	IN
cord-280549-bsnz24jx	22	21	insights	insight	NNS
cord-280549-bsnz24jx	22	22	into	into	IN
cord-280549-bsnz24jx	22	23	the	the	DT
cord-280549-bsnz24jx	22	24	intracellular	intracellular	JJ
cord-280549-bsnz24jx	22	25	viral	viral	JJ
cord-280549-bsnz24jx	22	26	lifecycle	lifecycle	NN
cord-280549-bsnz24jx	22	27	,	,	,
cord-280549-bsnz24jx	22	28	but	but	CC
cord-280549-bsnz24jx	22	29	also	also	RB
cord-280549-bsnz24jx	22	30	for	for	IN
cord-280549-bsnz24jx	22	31	development	development	NN
cord-280549-bsnz24jx	22	32	of	of	IN
cord-280549-bsnz24jx	22	33	strategies	strategy	NNS
cord-280549-bsnz24jx	22	34	to	to	TO
cord-280549-bsnz24jx	22	35	counteract	counteract	VB
cord-280549-bsnz24jx	22	36	viral	viral	JJ
cord-280549-bsnz24jx	22	37	infection	infection	NN
cord-280549-bsnz24jx	22	38	.	.	.
cord-280549-bsnz24jx	23	1	Viruses	virus	NNS
cord-280549-bsnz24jx	23	2	associated	associate	VBN
cord-280549-bsnz24jx	23	3	with	with	IN
cord-280549-bsnz24jx	23	4	human	human	JJ
cord-280549-bsnz24jx	23	5	cancer	cancer	NN
cord-280549-bsnz24jx	23	6	have	have	VBP
cord-280549-bsnz24jx	23	7	been	be	VBN
cord-280549-bsnz24jx	23	8	the	the	DT
cord-280549-bsnz24jx	23	9	focus	focus	NN
cord-280549-bsnz24jx	23	10	of	of	IN
cord-280549-bsnz24jx	23	11	scores	score	NNS
cord-280549-bsnz24jx	23	12	of	of	IN
cord-280549-bsnz24jx	23	13	studies	study	NNS
cord-280549-bsnz24jx	23	14	that	that	WDT
cord-280549-bsnz24jx	23	15	have	have	VBP
cord-280549-bsnz24jx	23	16	led	lead	VBN
cord-280549-bsnz24jx	23	17	to	to	IN
cord-280549-bsnz24jx	23	18	the	the	DT
cord-280549-bsnz24jx	23	19	identification	identification	NN
cord-280549-bsnz24jx	23	20	of	of	IN
cord-280549-bsnz24jx	23	21	cellular	cellular	JJ
cord-280549-bsnz24jx	23	22	networks	network	NNS
cord-280549-bsnz24jx	23	23	regulating	regulate	VBG
cord-280549-bsnz24jx	23	24	the	the	DT
cord-280549-bsnz24jx	23	25	cell	cell	NN
cord-280549-bsnz24jx	23	26	cycle	cycle	NN
cord-280549-bsnz24jx	23	27	,	,	,
cord-280549-bsnz24jx	23	28	including	include	VBG
cord-280549-bsnz24jx	23	29	the	the	DT
cord-280549-bsnz24jx	23	30	discovery	discovery	NN
cord-280549-bsnz24jx	23	31	of	of	IN
cord-280549-bsnz24jx	23	32	oncogenes	oncogene	NNS
cord-280549-bsnz24jx	23	33	and	and	CC
cord-280549-bsnz24jx	23	34	tumor	tumor	NN
cord-280549-bsnz24jx	23	35	suppressor	suppressor	NN
cord-280549-bsnz24jx	23	36	genes	gene	NNS
cord-280549-bsnz24jx	23	37	(	(	-LRB-
cord-280549-bsnz24jx	23	38	Bishop	Bishop	NNP
cord-280549-bsnz24jx	23	39	,	,	,
cord-280549-bsnz24jx	23	40	1991	1991	CD
cord-280549-bsnz24jx	23	41	;	;	:
cord-280549-bsnz24jx	23	42	Weinberg	Weinberg	NNP
cord-280549-bsnz24jx	23	43	,	,	,
cord-280549-bsnz24jx	23	44	1991	1991	CD
cord-280549-bsnz24jx	23	45	)	)	-RRB-
cord-280549-bsnz24jx	23	46	.	.	.
cord-280549-bsnz24jx	24	1	While	while	IN
cord-280549-bsnz24jx	24	2	discussion	discussion	NN
cord-280549-bsnz24jx	24	3	of	of	IN
cord-280549-bsnz24jx	24	4	their	-PRON-	PRP$
cord-280549-bsnz24jx	24	5	manipulation	manipulation	NN
cord-280549-bsnz24jx	24	6	of	of	IN
cord-280549-bsnz24jx	24	7	the	the	DT
cord-280549-bsnz24jx	24	8	cell	cell	NN
cord-280549-bsnz24jx	24	9	cycle	cycle	NN
cord-280549-bsnz24jx	24	10	is	be	VBZ
cord-280549-bsnz24jx	24	11	inevitable	inevitable	JJ
cord-280549-bsnz24jx	24	12	,	,	,
cord-280549-bsnz24jx	24	13	oncogenic	oncogenic	JJ
cord-280549-bsnz24jx	24	14	viruses	virus	NNS
cord-280549-bsnz24jx	24	15	will	will	MD
cord-280549-bsnz24jx	24	16	not	not	RB
cord-280549-bsnz24jx	24	17	be	be	VB
cord-280549-bsnz24jx	24	18	the	the	DT
cord-280549-bsnz24jx	24	19	focus	focus	NN
cord-280549-bsnz24jx	24	20	of	of	IN
cord-280549-bsnz24jx	24	21	this	this	DT
cord-280549-bsnz24jx	24	22	article	article	NN
cord-280549-bsnz24jx	24	23	and	and	CC
cord-280549-bsnz24jx	24	24	the	the	DT
cord-280549-bsnz24jx	24	25	reader	reader	NN
cord-280549-bsnz24jx	24	26	is	be	VBZ
cord-280549-bsnz24jx	24	27	referred	refer	VBN
cord-280549-bsnz24jx	24	28	to	to	IN
cord-280549-bsnz24jx	24	29	a	a	DT
cord-280549-bsnz24jx	24	30	number	number	NN
cord-280549-bsnz24jx	24	31	of	of	IN
cord-280549-bsnz24jx	24	32	excellent	excellent	JJ
cord-280549-bsnz24jx	24	33	reviews	review	NNS
cord-280549-bsnz24jx	24	34	on	on	IN
cord-280549-bsnz24jx	24	35	this	this	DT
cord-280549-bsnz24jx	24	36	topic	topic	NN
cord-280549-bsnz24jx	24	37	(	(	-LRB-
cord-280549-bsnz24jx	24	38	Weinberg	Weinberg	NNP
cord-280549-bsnz24jx	24	39	,	,	,
cord-280549-bsnz24jx	24	40	1997	1997	CD
cord-280549-bsnz24jx	24	41	;	;	:
cord-280549-bsnz24jx	24	42	zur	zur	NNP
cord-280549-bsnz24jx	24	43	Hausen	Hausen	NNP
cord-280549-bsnz24jx	24	44	,	,	,
cord-280549-bsnz24jx	24	45	2001	2001	CD
cord-280549-bsnz24jx	24	46	;	;	:
cord-280549-bsnz24jx	25	1	Chang	Chang	NNP
cord-280549-bsnz24jx	25	2	et	et	NNP
cord-280549-bsnz24jx	25	3	al	al	NNP
cord-280549-bsnz24jx	25	4	.	.	NNP
cord-280549-bsnz24jx	25	5	,	,	,
cord-280549-bsnz24jx	25	6	2017	2017	CD
cord-280549-bsnz24jx	25	7	)	)	-RRB-
cord-280549-bsnz24jx	25	8	.	.	.
cord-280549-bsnz24jx	26	1	Rather	rather	RB
cord-280549-bsnz24jx	26	2	,	,	,
cord-280549-bsnz24jx	26	3	we	-PRON-	PRP
cord-280549-bsnz24jx	26	4	summarize	summarize	VBP
cord-280549-bsnz24jx	26	5	and	and	CC
cord-280549-bsnz24jx	26	6	discuss	discuss	VBP
cord-280549-bsnz24jx	26	7	here	here	RB
cord-280549-bsnz24jx	26	8	current	current	JJ
cord-280549-bsnz24jx	26	9	concepts	concept	NNS
cord-280549-bsnz24jx	26	10	of	of	IN
cord-280549-bsnz24jx	26	11	the	the	DT
cord-280549-bsnz24jx	26	12	mechanistic	mechanistic	JJ
cord-280549-bsnz24jx	26	13	features	feature	NNS
cord-280549-bsnz24jx	26	14	that	that	WDT
cord-280549-bsnz24jx	26	15	non	non	JJ
cord-280549-bsnz24jx	26	16	-	-	JJ
cord-280549-bsnz24jx	26	17	oncogenic	oncogenic	JJ
cord-280549-bsnz24jx	26	18	viruses	virus	NNS
cord-280549-bsnz24jx	26	19	adopt	adopt	VBP
cord-280549-bsnz24jx	26	20	to	to	TO
cord-280549-bsnz24jx	26	21	modify	modify	VB
cord-280549-bsnz24jx	26	22	host	host	NN
cord-280549-bsnz24jx	26	23	cell	cell	NN
cord-280549-bsnz24jx	26	24	cycle	cycle	NN
cord-280549-bsnz24jx	26	25	machinery	machinery	NN
cord-280549-bsnz24jx	26	26	.	.	.
cord-280549-bsnz24jx	27	1	Cell	cell	NN
cord-280549-bsnz24jx	27	2	cycle	cycle	NN
cord-280549-bsnz24jx	27	3	,	,	,
cord-280549-bsnz24jx	27	4	or	or	CC
cord-280549-bsnz24jx	27	5	cell	cell	NN
cord-280549-bsnz24jx	27	6	-	-	HYPH
cord-280549-bsnz24jx	27	7	division	division	NN
cord-280549-bsnz24jx	27	8	cycle	cycle	NN
cord-280549-bsnz24jx	27	9	,	,	,
cord-280549-bsnz24jx	27	10	is	be	VBZ
cord-280549-bsnz24jx	27	11	a	a	DT
cord-280549-bsnz24jx	27	12	highly	highly	RB
cord-280549-bsnz24jx	27	13	regulated	regulate	VBN
cord-280549-bsnz24jx	27	14	process	process	NN
cord-280549-bsnz24jx	27	15	during	during	IN
cord-280549-bsnz24jx	27	16	which	which	WDT
cord-280549-bsnz24jx	27	17	a	a	DT
cord-280549-bsnz24jx	27	18	cell	cell	NN
cord-280549-bsnz24jx	27	19	undergoes	undergo	VBZ
cord-280549-bsnz24jx	27	20	duplication	duplication	NN
cord-280549-bsnz24jx	27	21	and	and	CC
cord-280549-bsnz24jx	27	22	division	division	NN
cord-280549-bsnz24jx	27	23	leading	lead	VBG
cord-280549-bsnz24jx	27	24	to	to	IN
cord-280549-bsnz24jx	27	25	the	the	DT
cord-280549-bsnz24jx	27	26	generation	generation	NN
cord-280549-bsnz24jx	27	27	of	of	IN
cord-280549-bsnz24jx	27	28	two	two	CD
cord-280549-bsnz24jx	27	29	daughter	daughter	NN
cord-280549-bsnz24jx	27	30	cells	cell	NNS
cord-280549-bsnz24jx	27	31	.	.	.
cord-280549-bsnz24jx	28	1	The	the	DT
cord-280549-bsnz24jx	28	2	eukaryotic	eukaryotic	JJ
cord-280549-bsnz24jx	28	3	cell	cell	NN
cord-280549-bsnz24jx	28	4	cycle	cycle	NN
cord-280549-bsnz24jx	28	5	is	be	VBZ
cord-280549-bsnz24jx	28	6	generally	generally	RB
cord-280549-bsnz24jx	28	7	divided	divide	VBN
cord-280549-bsnz24jx	28	8	into	into	IN
cord-280549-bsnz24jx	28	9	four	four	CD
cord-280549-bsnz24jx	28	10	stages	stage	NNS
cord-280549-bsnz24jx	28	11	:	:	:
cord-280549-bsnz24jx	28	12	gap	gap	NN
cord-280549-bsnz24jx	28	13	1	1	CD
cord-280549-bsnz24jx	28	14	phase	phase	NN
cord-280549-bsnz24jx	28	15	(	(	-LRB-
cord-280549-bsnz24jx	28	16	G1	G1	NNP
cord-280549-bsnz24jx	28	17	)	)	-RRB-
cord-280549-bsnz24jx	28	18	,	,	,
cord-280549-bsnz24jx	28	19	synthesis	synthesis	NN
cord-280549-bsnz24jx	28	20	phase	phase	NN
cord-280549-bsnz24jx	28	21	(	(	-LRB-
cord-280549-bsnz24jx	28	22	S	S	NNP
cord-280549-bsnz24jx	28	23	)	)	-RRB-
cord-280549-bsnz24jx	28	24	,	,	,
cord-280549-bsnz24jx	28	25	gap	gap	NN
cord-280549-bsnz24jx	28	26	2	2	CD
cord-280549-bsnz24jx	28	27	phase	phase	NN
cord-280549-bsnz24jx	28	28	(	(	-LRB-
cord-280549-bsnz24jx	28	29	G2	G2	NNP
cord-280549-bsnz24jx	28	30	)	)	-RRB-
cord-280549-bsnz24jx	28	31	,	,	,
cord-280549-bsnz24jx	28	32	and	and	CC
cord-280549-bsnz24jx	28	33	mitotic	mitotic	JJ
cord-280549-bsnz24jx	28	34	phase	phase	NN
cord-280549-bsnz24jx	28	35	(	(	-LRB-
cord-280549-bsnz24jx	28	36	M	M	NNP
cord-280549-bsnz24jx	28	37	)	)	-RRB-
cord-280549-bsnz24jx	28	38	.	.	.
cord-280549-bsnz24jx	29	1	In	in	IN
cord-280549-bsnz24jx	29	2	between	between	IN
cord-280549-bsnz24jx	29	3	M	M	NNP
cord-280549-bsnz24jx	29	4	and	and	CC
cord-280549-bsnz24jx	29	5	G1	G1	NNP
cord-280549-bsnz24jx	29	6	,	,	,
cord-280549-bsnz24jx	29	7	a	a	DT
cord-280549-bsnz24jx	29	8	cell	cell	NN
cord-280549-bsnz24jx	29	9	may	may	MD
cord-280549-bsnz24jx	29	10	enter	enter	VB
cord-280549-bsnz24jx	29	11	a	a	DT
cord-280549-bsnz24jx	29	12	quiescent	quiescent	JJ
cord-280549-bsnz24jx	29	13	state	state	NN
cord-280549-bsnz24jx	29	14	called	call	VBN
cord-280549-bsnz24jx	29	15	gap	gap	NN
cord-280549-bsnz24jx	29	16	0	0	CD
cord-280549-bsnz24jx	29	17	phase	phase	NN
cord-280549-bsnz24jx	29	18	(	(	-LRB-
cord-280549-bsnz24jx	29	19	G0	G0	NNP
cord-280549-bsnz24jx	29	20	)	)	-RRB-
cord-280549-bsnz24jx	29	21	,	,	,
cord-280549-bsnz24jx	29	22	during	during	IN
cord-280549-bsnz24jx	29	23	which	which	WDT
cord-280549-bsnz24jx	29	24	cells	cell	NNS
cord-280549-bsnz24jx	29	25	are	be	VBP
cord-280549-bsnz24jx	29	26	neither	neither	DT
cord-280549-bsnz24jx	29	27	dividing	divide	VBG
cord-280549-bsnz24jx	29	28	nor	nor	CC
cord-280549-bsnz24jx	29	29	preparing	prepare	VBG
cord-280549-bsnz24jx	29	30	to	to	TO
cord-280549-bsnz24jx	29	31	divide	divide	VB
cord-280549-bsnz24jx	29	32	.	.	.
cord-280549-bsnz24jx	30	1	G1	G1	NNP
cord-280549-bsnz24jx	30	2	is	be	VBZ
cord-280549-bsnz24jx	30	3	the	the	DT
cord-280549-bsnz24jx	30	4	phase	phase	NN
cord-280549-bsnz24jx	30	5	during	during	IN
cord-280549-bsnz24jx	30	6	which	which	WDT
cord-280549-bsnz24jx	30	7	metabolic	metabolic	JJ
cord-280549-bsnz24jx	30	8	changes	change	NNS
cord-280549-bsnz24jx	30	9	take	take	VBP
cord-280549-bsnz24jx	30	10	place	place	NN
cord-280549-bsnz24jx	30	11	to	to	TO
cord-280549-bsnz24jx	30	12	prepare	prepare	VB
cord-280549-bsnz24jx	30	13	the	the	DT
cord-280549-bsnz24jx	30	14	cell	cell	NN
cord-280549-bsnz24jx	30	15	for	for	IN
cord-280549-bsnz24jx	30	16	division	division	NN
cord-280549-bsnz24jx	30	17	.	.	.
cord-280549-bsnz24jx	31	1	Events	event	NNS
cord-280549-bsnz24jx	31	2	that	that	WDT
cord-280549-bsnz24jx	31	3	take	take	VBP
cord-280549-bsnz24jx	31	4	place	place	NN
cord-280549-bsnz24jx	31	5	in	in	IN
cord-280549-bsnz24jx	31	6	G1	G1	NNP
cord-280549-bsnz24jx	31	7	include	include	VBP
cord-280549-bsnz24jx	31	8	growth	growth	NN
cord-280549-bsnz24jx	31	9	in	in	IN
cord-280549-bsnz24jx	31	10	cell	cell	NN
cord-280549-bsnz24jx	31	11	size	size	NN
cord-280549-bsnz24jx	31	12	as	as	RB
cord-280549-bsnz24jx	31	13	well	well	RB
cord-280549-bsnz24jx	31	14	as	as	IN
cord-280549-bsnz24jx	31	15	mRNA	mRNA	NNP
cord-280549-bsnz24jx	31	16	and	and	CC
cord-280549-bsnz24jx	31	17	protein	protein	NN
cord-280549-bsnz24jx	31	18	synthesis	synthesis	NN
cord-280549-bsnz24jx	31	19	.	.	.
cord-280549-bsnz24jx	32	1	Initiation	initiation	NN
cord-280549-bsnz24jx	32	2	of	of	IN
cord-280549-bsnz24jx	32	3	G1	G1	NNP
cord-280549-bsnz24jx	32	4	phase	phase	NN
cord-280549-bsnz24jx	32	5	requires	require	VBZ
cord-280549-bsnz24jx	32	6	growth	growth	NN
cord-280549-bsnz24jx	32	7	factor	factor	NN
cord-280549-bsnz24jx	32	8	stimulation	stimulation	NN
cord-280549-bsnz24jx	32	9	and	and	CC
cord-280549-bsnz24jx	32	10	a	a	DT
cord-280549-bsnz24jx	32	11	continuous	continuous	JJ
cord-280549-bsnz24jx	32	12	supply	supply	NN
cord-280549-bsnz24jx	32	13	of	of	IN
cord-280549-bsnz24jx	32	14	growth	growth	NN
cord-280549-bsnz24jx	32	15	factor	factor	NN
cord-280549-bsnz24jx	32	16	until	until	IN
cord-280549-bsnz24jx	32	17	the	the	DT
cord-280549-bsnz24jx	32	18	cell	cell	NN
cord-280549-bsnz24jx	32	19	cycle	cycle	NN
cord-280549-bsnz24jx	32	20	passes	pass	VBZ
cord-280549-bsnz24jx	32	21	through	through	IN
cord-280549-bsnz24jx	32	22	the	the	DT
cord-280549-bsnz24jx	32	23	restriction	restriction	NN
cord-280549-bsnz24jx	32	24	point	point	NN
cord-280549-bsnz24jx	32	25	(	(	-LRB-
cord-280549-bsnz24jx	32	26	Pardee	Pardee	NNP
cord-280549-bsnz24jx	32	27	,	,	,
cord-280549-bsnz24jx	32	28	1974	1974	CD
cord-280549-bsnz24jx	32	29	)	)	-RRB-
cord-280549-bsnz24jx	32	30	in	in	IN
cord-280549-bsnz24jx	32	31	G1	G1	NNP
cord-280549-bsnz24jx	32	32	,	,	,
cord-280549-bsnz24jx	32	33	after	after	IN
cord-280549-bsnz24jx	32	34	which	which	WDT
cord-280549-bsnz24jx	32	35	cells	cell	NNS
cord-280549-bsnz24jx	32	36	are	be	VBP
cord-280549-bsnz24jx	32	37	committed	commit	VBN
cord-280549-bsnz24jx	32	38	to	to	IN
cord-280549-bsnz24jx	32	39	DNA	dna	NN
cord-280549-bsnz24jx	32	40	synthesis	synthesis	NN
cord-280549-bsnz24jx	32	41	to	to	TO
cord-280549-bsnz24jx	32	42	complete	complete	VB
cord-280549-bsnz24jx	32	43	the	the	DT
cord-280549-bsnz24jx	32	44	cell	cell	NN
cord-280549-bsnz24jx	32	45	cycle	cycle	NN
cord-280549-bsnz24jx	32	46	and	and	CC
cord-280549-bsnz24jx	32	47	become	become	VB
cord-280549-bsnz24jx	32	48	extracellular	extracellular	JJ
cord-280549-bsnz24jx	32	49	growth	growth	NN
cord-280549-bsnz24jx	32	50	factor	factor	NN
cord-280549-bsnz24jx	32	51	-	-	HYPH
cord-280549-bsnz24jx	32	52	independent	independent	JJ
cord-280549-bsnz24jx	32	53	throughout	throughout	IN
cord-280549-bsnz24jx	32	54	the	the	DT
cord-280549-bsnz24jx	32	55	remainder	remainder	NN
cord-280549-bsnz24jx	32	56	of	of	IN
cord-280549-bsnz24jx	32	57	the	the	DT
cord-280549-bsnz24jx	32	58	cell	cell	NN
cord-280549-bsnz24jx	32	59	cycle	cycle	NN
cord-280549-bsnz24jx	33	1	(	(	-LRB-
cord-280549-bsnz24jx	33	2	Zetterberg	Zetterberg	NNP
cord-280549-bsnz24jx	33	3	et	et	NNP
cord-280549-bsnz24jx	33	4	al	al	NNP
cord-280549-bsnz24jx	33	5	.	.	NNP
cord-280549-bsnz24jx	33	6	,	,	,
cord-280549-bsnz24jx	33	7	1995	1995	CD
cord-280549-bsnz24jx	33	8	)	)	-RRB-
cord-280549-bsnz24jx	33	9	.	.	.
cord-280549-bsnz24jx	34	1	The	the	DT
cord-280549-bsnz24jx	34	2	retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	34	3	(	(	-LRB-
cord-280549-bsnz24jx	34	4	Rb	rb	NN
cord-280549-bsnz24jx	34	5	)	)	-RRB-
cord-280549-bsnz24jx	34	6	protein	protein	NN
cord-280549-bsnz24jx	34	7	is	be	VBZ
cord-280549-bsnz24jx	34	8	the	the	DT
cord-280549-bsnz24jx	34	9	guardian	guardian	NN
cord-280549-bsnz24jx	34	10	of	of	IN
cord-280549-bsnz24jx	34	11	restriction	restriction	NN
cord-280549-bsnz24jx	34	12	point	point	NN
cord-280549-bsnz24jx	35	1	(	(	-LRB-
cord-280549-bsnz24jx	35	2	Bartek	Bartek	NNP
cord-280549-bsnz24jx	35	3	et	et	NNP
cord-280549-bsnz24jx	35	4	al	al	NNP
cord-280549-bsnz24jx	35	5	.	.	NNP
cord-280549-bsnz24jx	35	6	,	,	,
cord-280549-bsnz24jx	35	7	1996	1996	CD
cord-280549-bsnz24jx	35	8	)	)	-RRB-
cord-280549-bsnz24jx	35	9	.	.	.
cord-280549-bsnz24jx	36	1	When	when	WRB
cord-280549-bsnz24jx	36	2	conditions	condition	NNS
cord-280549-bsnz24jx	36	3	are	be	VBP
cord-280549-bsnz24jx	36	4	propitious	propitious	JJ
cord-280549-bsnz24jx	36	5	for	for	IN
cord-280549-bsnz24jx	36	6	cell	cell	NN
cord-280549-bsnz24jx	36	7	division	division	NN
cord-280549-bsnz24jx	36	8	without	without	IN
cord-280549-bsnz24jx	36	9	warning	warning	NN
cord-280549-bsnz24jx	36	10	signals	signal	NNS
cord-280549-bsnz24jx	36	11	such	such	JJ
cord-280549-bsnz24jx	36	12	as	as	IN
cord-280549-bsnz24jx	36	13	DNA	dna	NN
cord-280549-bsnz24jx	36	14	damage	damage	NN
cord-280549-bsnz24jx	36	15	or	or	CC
cord-280549-bsnz24jx	36	16	metabolic	metabolic	JJ
cord-280549-bsnz24jx	36	17	disturbances	disturbance	NNS
cord-280549-bsnz24jx	36	18	,	,	,
cord-280549-bsnz24jx	36	19	Rb	Rb	NNP
cord-280549-bsnz24jx	36	20	undergoes	undergo	VBZ
cord-280549-bsnz24jx	36	21	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	36	22	and	and	CC
cord-280549-bsnz24jx	36	23	become	become	VB
cord-280549-bsnz24jx	36	24	functionally	functionally	RB
cord-280549-bsnz24jx	36	25	inactivated	inactivate	VBN
cord-280549-bsnz24jx	36	26	,	,	,
cord-280549-bsnz24jx	36	27	permitting	permit	VBG
cord-280549-bsnz24jx	36	28	the	the	DT
cord-280549-bsnz24jx	36	29	cell	cell	NN
cord-280549-bsnz24jx	36	30	to	to	TO
cord-280549-bsnz24jx	36	31	proceed	proceed	VB
cord-280549-bsnz24jx	36	32	into	into	IN
cord-280549-bsnz24jx	36	33	late	late	JJ
cord-280549-bsnz24jx	36	34	G1	G1	NNP
cord-280549-bsnz24jx	36	35	(	(	-LRB-
cord-280549-bsnz24jx	36	36	Weinberg	Weinberg	NNP
cord-280549-bsnz24jx	36	37	,	,	,
cord-280549-bsnz24jx	36	38	1995	1995	CD
cord-280549-bsnz24jx	36	39	)	)	-RRB-
cord-280549-bsnz24jx	36	40	.	.	.
cord-280549-bsnz24jx	37	1	DNA	dna	NN
cord-280549-bsnz24jx	37	2	synthesis	synthesis	NN
cord-280549-bsnz24jx	37	3	takes	take	VBZ
cord-280549-bsnz24jx	37	4	place	place	NN
cord-280549-bsnz24jx	37	5	in	in	IN
cord-280549-bsnz24jx	37	6	S	s	NN
cord-280549-bsnz24jx	37	7	phase	phase	NN
cord-280549-bsnz24jx	37	8	,	,	,
cord-280549-bsnz24jx	37	9	generating	generate	VBG
cord-280549-bsnz24jx	37	10	exactly	exactly	RB
cord-280549-bsnz24jx	37	11	two	two	CD
cord-280549-bsnz24jx	37	12	identical	identical	JJ
cord-280549-bsnz24jx	37	13	sister	sister	NN
cord-280549-bsnz24jx	37	14	chromosomes	chromosome	NNS
cord-280549-bsnz24jx	37	15	.	.	.
cord-280549-bsnz24jx	38	1	G2	G2	NNP
cord-280549-bsnz24jx	38	2	phase	phase	NN
cord-280549-bsnz24jx	38	3	is	be	VBZ
cord-280549-bsnz24jx	38	4	a	a	DT
cord-280549-bsnz24jx	38	5	period	period	NN
cord-280549-bsnz24jx	38	6	of	of	IN
cord-280549-bsnz24jx	38	7	rapid	rapid	JJ
cord-280549-bsnz24jx	38	8	cell	cell	NN
cord-280549-bsnz24jx	38	9	growth	growth	NN
cord-280549-bsnz24jx	38	10	and	and	CC
cord-280549-bsnz24jx	38	11	protein	protein	NN
cord-280549-bsnz24jx	38	12	synthesis	synthesis	NN
cord-280549-bsnz24jx	38	13	during	during	IN
cord-280549-bsnz24jx	38	14	which	which	WDT
cord-280549-bsnz24jx	38	15	cells	cell	NNS
cord-280549-bsnz24jx	38	16	get	get	VBP
cord-280549-bsnz24jx	38	17	ready	ready	JJ
cord-280549-bsnz24jx	38	18	for	for	IN
cord-280549-bsnz24jx	38	19	mitosis	mitosis	NN
cord-280549-bsnz24jx	38	20	.	.	.
cord-280549-bsnz24jx	39	1	DNA	dna	NN
cord-280549-bsnz24jx	39	2	damage	damage	NN
cord-280549-bsnz24jx	39	3	and	and	CC
cord-280549-bsnz24jx	39	4	replication	replication	NN
cord-280549-bsnz24jx	39	5	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	39	6	exists	exist	VBZ
cord-280549-bsnz24jx	39	7	in	in	IN
cord-280549-bsnz24jx	39	8	G2	G2	NNP
cord-280549-bsnz24jx	39	9	to	to	TO
cord-280549-bsnz24jx	39	10	monitor	monitor	VB
cord-280549-bsnz24jx	39	11	if	if	IN
cord-280549-bsnz24jx	39	12	chromosome	chromosome	NN
cord-280549-bsnz24jx	39	13	replication	replication	NN
cord-280549-bsnz24jx	39	14	is	be	VBZ
cord-280549-bsnz24jx	39	15	successfully	successfully	RB
cord-280549-bsnz24jx	39	16	completed	complete	VBN
cord-280549-bsnz24jx	39	17	and	and	CC
cord-280549-bsnz24jx	39	18	whether	whether	IN
cord-280549-bsnz24jx	39	19	DNA	dna	NN
cord-280549-bsnz24jx	39	20	damage	damage	NN
cord-280549-bsnz24jx	39	21	occurs	occur	VBZ
cord-280549-bsnz24jx	39	22	during	during	IN
cord-280549-bsnz24jx	39	23	the	the	DT
cord-280549-bsnz24jx	39	24	process	process	NN
cord-280549-bsnz24jx	39	25	(	(	-LRB-
cord-280549-bsnz24jx	39	26	Hartwell	Hartwell	NNP
cord-280549-bsnz24jx	39	27	and	and	CC
cord-280549-bsnz24jx	39	28	Weinert	Weinert	NNP
cord-280549-bsnz24jx	39	29	,	,	,
cord-280549-bsnz24jx	39	30	1989	1989	CD
cord-280549-bsnz24jx	39	31	)	)	-RRB-
cord-280549-bsnz24jx	39	32	.	.	.
cord-280549-bsnz24jx	40	1	This	this	DT
cord-280549-bsnz24jx	40	2	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	40	3	determines	determine	VBZ
cord-280549-bsnz24jx	40	4	the	the	DT
cord-280549-bsnz24jx	40	5	fate	fate	NN
cord-280549-bsnz24jx	40	6	of	of	IN
cord-280549-bsnz24jx	40	7	a	a	DT
cord-280549-bsnz24jx	40	8	cell	cell	NN
cord-280549-bsnz24jx	40	9	,	,	,
cord-280549-bsnz24jx	40	10	either	either	RB
cord-280549-bsnz24jx	40	11	to	to	TO
cord-280549-bsnz24jx	40	12	enter	enter	VB
cord-280549-bsnz24jx	40	13	mitosis	mitosis	NN
cord-280549-bsnz24jx	40	14	or	or	CC
cord-280549-bsnz24jx	40	15	to	to	TO
cord-280549-bsnz24jx	40	16	undergo	undergo	VB
cord-280549-bsnz24jx	40	17	growth	growth	NN
cord-280549-bsnz24jx	40	18	arrest	arrest	NN
cord-280549-bsnz24jx	40	19	for	for	IN
cord-280549-bsnz24jx	40	20	DNA	dna	NN
cord-280549-bsnz24jx	40	21	repair	repair	NN
cord-280549-bsnz24jx	40	22	.	.	.
cord-280549-bsnz24jx	41	1	Mitosis	mitosis	NN
cord-280549-bsnz24jx	41	2	is	be	VBZ
cord-280549-bsnz24jx	41	3	the	the	DT
cord-280549-bsnz24jx	41	4	process	process	NN
cord-280549-bsnz24jx	41	5	during	during	IN
cord-280549-bsnz24jx	41	6	which	which	WDT
cord-280549-bsnz24jx	41	7	eukaryotic	eukaryotic	JJ
cord-280549-bsnz24jx	41	8	sister	sister	NN
cord-280549-bsnz24jx	41	9	chromatid	chromatid	NNS
cord-280549-bsnz24jx	41	10	get	get	VBP
cord-280549-bsnz24jx	41	11	separated	separate	VBN
cord-280549-bsnz24jx	41	12	to	to	TO
cord-280549-bsnz24jx	41	13	generate	generate	VB
cord-280549-bsnz24jx	41	14	two	two	CD
cord-280549-bsnz24jx	41	15	nuclei	nucleus	NNS
cord-280549-bsnz24jx	41	16	(	(	-LRB-
cord-280549-bsnz24jx	41	17	Pines	Pines	NNP
cord-280549-bsnz24jx	41	18	and	and	CC
cord-280549-bsnz24jx	41	19	Rieder	Rieder	NNP
cord-280549-bsnz24jx	41	20	,	,	,
cord-280549-bsnz24jx	41	21	2001	2001	CD
cord-280549-bsnz24jx	41	22	)	)	-RRB-
cord-280549-bsnz24jx	41	23	.	.	.
cord-280549-bsnz24jx	42	1	A	a	DT
cord-280549-bsnz24jx	42	2	metaphase	metaphase	NN
cord-280549-bsnz24jx	42	3	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	42	4	detects	detect	VBZ
cord-280549-bsnz24jx	42	5	whether	whether	IN
cord-280549-bsnz24jx	42	6	all	all	DT
cord-280549-bsnz24jx	42	7	chromosomes	chromosome	NNS
cord-280549-bsnz24jx	42	8	are	be	VBP
cord-280549-bsnz24jx	42	9	properly	properly	RB
cord-280549-bsnz24jx	42	10	attached	attach	VBN
cord-280549-bsnz24jx	42	11	to	to	IN
cord-280549-bsnz24jx	42	12	mitotic	mitotic	JJ
cord-280549-bsnz24jx	42	13	spindles	spindle	NNS
cord-280549-bsnz24jx	42	14	(	(	-LRB-
cord-280549-bsnz24jx	42	15	spindle	spindle	NN
cord-280549-bsnz24jx	42	16	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	42	17	)	)	-RRB-
cord-280549-bsnz24jx	42	18	,	,	,
cord-280549-bsnz24jx	42	19	to	to	TO
cord-280549-bsnz24jx	42	20	ensure	ensure	VB
cord-280549-bsnz24jx	42	21	equal	equal	JJ
cord-280549-bsnz24jx	42	22	separation	separation	NN
cord-280549-bsnz24jx	42	23	of	of	IN
cord-280549-bsnz24jx	42	24	sister	sister	NN
cord-280549-bsnz24jx	42	25	chromatid	chromatid	NNP
cord-280549-bsnz24jx	42	26	(	(	-LRB-
cord-280549-bsnz24jx	42	27	Gorbsky	Gorbsky	NNP
cord-280549-bsnz24jx	42	28	,	,	,
cord-280549-bsnz24jx	42	29	1995	1995	CD
cord-280549-bsnz24jx	42	30	)	)	-RRB-
cord-280549-bsnz24jx	42	31	.	.	.
cord-280549-bsnz24jx	43	1	Cell	cell	NN
cord-280549-bsnz24jx	43	2	division	division	NN
cord-280549-bsnz24jx	43	3	is	be	VBZ
cord-280549-bsnz24jx	43	4	completed	complete	VBN
cord-280549-bsnz24jx	43	5	by	by	IN
cord-280549-bsnz24jx	43	6	cytokinesis	cytokinesis	NN
cord-280549-bsnz24jx	43	7	,	,	,
cord-280549-bsnz24jx	43	8	which	which	WDT
cord-280549-bsnz24jx	43	9	segregates	segregate	VBZ
cord-280549-bsnz24jx	43	10	the	the	DT
cord-280549-bsnz24jx	43	11	nuclei	nucleus	NNS
cord-280549-bsnz24jx	43	12	,	,	,
cord-280549-bsnz24jx	43	13	cytoplasm	cytoplasm	NN
cord-280549-bsnz24jx	43	14	,	,	,
cord-280549-bsnz24jx	43	15	organelles	organelle	NNS
cord-280549-bsnz24jx	43	16	,	,	,
cord-280549-bsnz24jx	43	17	and	and	CC
cord-280549-bsnz24jx	43	18	cell	cell	NN
cord-280549-bsnz24jx	43	19	membrane	membrane	NN
cord-280549-bsnz24jx	43	20	into	into	IN
cord-280549-bsnz24jx	43	21	two	two	CD
cord-280549-bsnz24jx	43	22	genetically	genetically	RB
cord-280549-bsnz24jx	43	23	identical	identical	JJ
cord-280549-bsnz24jx	43	24	daughter	daughter	NN
cord-280549-bsnz24jx	43	25	cells	cell	NNS
cord-280549-bsnz24jx	43	26	(	(	-LRB-
cord-280549-bsnz24jx	43	27	Straight	Straight	NNP
cord-280549-bsnz24jx	43	28	and	and	CC
cord-280549-bsnz24jx	43	29	Field	Field	NNP
cord-280549-bsnz24jx	43	30	,	,	,
cord-280549-bsnz24jx	43	31	2000	2000	CD
cord-280549-bsnz24jx	43	32	;	;	:
cord-280549-bsnz24jx	43	33	Glotzer	Glotzer	NNP
cord-280549-bsnz24jx	43	34	,	,	,
cord-280549-bsnz24jx	43	35	2001	2001	CD
cord-280549-bsnz24jx	43	36	)	)	-RRB-
cord-280549-bsnz24jx	43	37	.	.	.
cord-280549-bsnz24jx	44	1	Thus	thus	RB
cord-280549-bsnz24jx	44	2	,	,	,
cord-280549-bsnz24jx	44	3	cell	cell	NN
cord-280549-bsnz24jx	44	4	cycle	cycle	NN
cord-280549-bsnz24jx	44	5	is	be	VBZ
cord-280549-bsnz24jx	44	6	a	a	DT
cord-280549-bsnz24jx	44	7	highly	highly	RB
cord-280549-bsnz24jx	44	8	regulated	regulate	VBN
cord-280549-bsnz24jx	44	9	process	process	NN
cord-280549-bsnz24jx	44	10	where	where	WRB
cord-280549-bsnz24jx	44	11	multiple	multiple	JJ
cord-280549-bsnz24jx	44	12	checkpoints	checkpoint	NNS
cord-280549-bsnz24jx	44	13	determine	determine	VBP
cord-280549-bsnz24jx	44	14	whether	whether	IN
cord-280549-bsnz24jx	44	15	to	to	TO
cord-280549-bsnz24jx	44	16	continue	continue	VB
cord-280549-bsnz24jx	44	17	or	or	CC
cord-280549-bsnz24jx	44	18	abort	abort	VB
cord-280549-bsnz24jx	44	19	a	a	DT
cord-280549-bsnz24jx	44	20	division	division	NN
cord-280549-bsnz24jx	44	21	.	.	.
cord-280549-bsnz24jx	45	1	The	the	DT
cord-280549-bsnz24jx	45	2	initiation	initiation	NN
cord-280549-bsnz24jx	45	3	of	of	IN
cord-280549-bsnz24jx	45	4	specific	specific	JJ
cord-280549-bsnz24jx	45	5	events	event	NNS
cord-280549-bsnz24jx	45	6	during	during	IN
cord-280549-bsnz24jx	45	7	cell	cell	NN
cord-280549-bsnz24jx	45	8	cycle	cycle	NN
cord-280549-bsnz24jx	45	9	,	,	,
cord-280549-bsnz24jx	45	10	such	such	JJ
cord-280549-bsnz24jx	45	11	as	as	IN
cord-280549-bsnz24jx	45	12	preparation	preparation	NN
cord-280549-bsnz24jx	45	13	for	for	IN
cord-280549-bsnz24jx	45	14	cell	cell	NN
cord-280549-bsnz24jx	45	15	division	division	NN
cord-280549-bsnz24jx	45	16	,	,	,
cord-280549-bsnz24jx	45	17	DNA	dna	NN
cord-280549-bsnz24jx	45	18	replication	replication	NN
cord-280549-bsnz24jx	45	19	,	,	,
cord-280549-bsnz24jx	45	20	nuclear	nuclear	JJ
cord-280549-bsnz24jx	45	21	membrane	membrane	NN
cord-280549-bsnz24jx	45	22	breakdown	breakdown	NN
cord-280549-bsnz24jx	45	23	,	,	,
cord-280549-bsnz24jx	45	24	spindle	spindle	NN
cord-280549-bsnz24jx	45	25	formation	formation	NN
cord-280549-bsnz24jx	45	26	and	and	CC
cord-280549-bsnz24jx	45	27	chromosome	chromosome	NN
cord-280549-bsnz24jx	45	28	segregation	segregation	NN
cord-280549-bsnz24jx	45	29	,	,	,
cord-280549-bsnz24jx	45	30	is	be	VBZ
cord-280549-bsnz24jx	45	31	triggered	trigger	VBN
cord-280549-bsnz24jx	45	32	by	by	IN
cord-280549-bsnz24jx	45	33	a	a	DT
cord-280549-bsnz24jx	45	34	series	series	NN
cord-280549-bsnz24jx	45	35	of	of	IN
cord-280549-bsnz24jx	45	36	protein	protein	NN
cord-280549-bsnz24jx	45	37	complexes	complex	NNS
cord-280549-bsnz24jx	45	38	that	that	WDT
cord-280549-bsnz24jx	45	39	are	be	VBP
cord-280549-bsnz24jx	45	40	activated	activate	VBN
cord-280549-bsnz24jx	45	41	in	in	IN
cord-280549-bsnz24jx	45	42	a	a	DT
cord-280549-bsnz24jx	45	43	concerted	concerted	JJ
cord-280549-bsnz24jx	45	44	fashion	fashion	NN
cord-280549-bsnz24jx	45	45	.	.	.
cord-280549-bsnz24jx	46	1	The	the	DT
cord-280549-bsnz24jx	46	2	protein	protein	NN
cord-280549-bsnz24jx	46	3	complexes	complex	NNS
cord-280549-bsnz24jx	46	4	,	,	,
cord-280549-bsnz24jx	46	5	consisting	consist	VBG
cord-280549-bsnz24jx	46	6	of	of	IN
cord-280549-bsnz24jx	46	7	cyclin	cyclin	NN
cord-280549-bsnz24jx	46	8	and	and	CC
cord-280549-bsnz24jx	46	9	cyclin	cyclin	JJ
cord-280549-bsnz24jx	46	10	dependent	dependent	JJ
cord-280549-bsnz24jx	46	11	kinase	kinase	NN
cord-280549-bsnz24jx	46	12	(	(	-LRB-
cord-280549-bsnz24jx	46	13	CDK	CDK	NNP
cord-280549-bsnz24jx	46	14	)	)	-RRB-
cord-280549-bsnz24jx	46	15	,	,	,
cord-280549-bsnz24jx	46	16	constitute	constitute	VBP
cord-280549-bsnz24jx	46	17	the	the	DT
cord-280549-bsnz24jx	46	18	cell	cell	NN
cord-280549-bsnz24jx	46	19	cycle	cycle	NN
cord-280549-bsnz24jx	46	20	engine	engine	NN
cord-280549-bsnz24jx	46	21	,	,	,
cord-280549-bsnz24jx	46	22	which	which	WDT
cord-280549-bsnz24jx	46	23	is	be	VBZ
cord-280549-bsnz24jx	46	24	driven	drive	VBN
cord-280549-bsnz24jx	46	25	in	in	IN
cord-280549-bsnz24jx	46	26	a	a	DT
cord-280549-bsnz24jx	46	27	precise	precise	JJ
cord-280549-bsnz24jx	46	28	sequence	sequence	NN
cord-280549-bsnz24jx	46	29	with	with	IN
cord-280549-bsnz24jx	46	30	different	different	JJ
cord-280549-bsnz24jx	46	31	cyclin	cyclin	NN
cord-280549-bsnz24jx	46	32	-	-	HYPH
cord-280549-bsnz24jx	46	33	CDK	CDK	NNP
cord-280549-bsnz24jx	46	34	partners	partner	NNS
cord-280549-bsnz24jx	46	35	activated	activate	VBN
cord-280549-bsnz24jx	46	36	at	at	IN
cord-280549-bsnz24jx	46	37	specific	specific	JJ
cord-280549-bsnz24jx	46	38	points	point	NNS
cord-280549-bsnz24jx	46	39	of	of	IN
cord-280549-bsnz24jx	46	40	the	the	DT
cord-280549-bsnz24jx	46	41	cell	cell	NN
cord-280549-bsnz24jx	46	42	cycle	cycle	NN
cord-280549-bsnz24jx	46	43	.	.	.
cord-280549-bsnz24jx	47	1	Mammalian	mammalian	JJ
cord-280549-bsnz24jx	47	2	cells	cell	NNS
cord-280549-bsnz24jx	47	3	accommodate	accommodate	VBP
cord-280549-bsnz24jx	47	4	multiple	multiple	JJ
cord-280549-bsnz24jx	47	5	cell	cell	NN
cord-280549-bsnz24jx	47	6	cycle	cycle	NN
cord-280549-bsnz24jx	47	7	-	-	HYPH
cord-280549-bsnz24jx	47	8	regulatory	regulatory	JJ
cord-280549-bsnz24jx	47	9	cyclin	cyclin	NN
cord-280549-bsnz24jx	47	10	and	and	CC
cord-280549-bsnz24jx	47	11	CDKs	cdk	NNS
cord-280549-bsnz24jx	47	12	throughout	throughout	IN
cord-280549-bsnz24jx	47	13	the	the	DT
cord-280549-bsnz24jx	47	14	cell	cell	NN
cord-280549-bsnz24jx	47	15	cycle	cycle	NN
cord-280549-bsnz24jx	47	16	machinery	machinery	NN
cord-280549-bsnz24jx	47	17	probably	probably	RB
cord-280549-bsnz24jx	47	18	to	to	IN
cord-280549-bsnz24jx	47	19	fine	fine	JJ
cord-280549-bsnz24jx	47	20	-	-	HYPH
cord-280549-bsnz24jx	47	21	tune	tune	VB
cord-280549-bsnz24jx	47	22	the	the	DT
cord-280549-bsnz24jx	47	23	flexibility	flexibility	NN
cord-280549-bsnz24jx	47	24	of	of	IN
cord-280549-bsnz24jx	47	25	cell	cell	NN
cord-280549-bsnz24jx	47	26	cycle	cycle	NN
cord-280549-bsnz24jx	47	27	control	control	NN
cord-280549-bsnz24jx	47	28	(	(	-LRB-
cord-280549-bsnz24jx	47	29	Nigg	Nigg	NNP
cord-280549-bsnz24jx	47	30	,	,	,
cord-280549-bsnz24jx	47	31	1995	1995	CD
cord-280549-bsnz24jx	47	32	)	)	-RRB-
cord-280549-bsnz24jx	47	33	.	.	.
cord-280549-bsnz24jx	48	1	After	after	IN
cord-280549-bsnz24jx	48	2	mammalian	mammalian	JJ
cord-280549-bsnz24jx	48	3	cells	cell	NNS
cord-280549-bsnz24jx	48	4	are	be	VBP
cord-280549-bsnz24jx	48	5	released	release	VBN
cord-280549-bsnz24jx	48	6	from	from	IN
cord-280549-bsnz24jx	48	7	the	the	DT
cord-280549-bsnz24jx	48	8	quiescent	quiescent	JJ
cord-280549-bsnz24jx	48	9	state	state	NN
cord-280549-bsnz24jx	48	10	,	,	,
cord-280549-bsnz24jx	48	11	the	the	DT
cord-280549-bsnz24jx	48	12	first	first	JJ
cord-280549-bsnz24jx	48	13	cyclin	cyclin	NN
cord-280549-bsnz24jx	48	14	-	-	HYPH
cord-280549-bsnz24jx	48	15	CDK	CDK	NNP
cord-280549-bsnz24jx	48	16	holoenzyme	holoenzyme	NNS
cord-280549-bsnz24jx	48	17	known	know	VBN
cord-280549-bsnz24jx	48	18	to	to	TO
cord-280549-bsnz24jx	48	19	be	be	VB
cord-280549-bsnz24jx	48	20	activated	activate	VBN
cord-280549-bsnz24jx	48	21	is	be	VBZ
cord-280549-bsnz24jx	48	22	composed	compose	VBN
cord-280549-bsnz24jx	48	23	of	of	IN
cord-280549-bsnz24jx	48	24	a	a	DT
cord-280549-bsnz24jx	48	25	D	d	NN
cord-280549-bsnz24jx	48	26	-	-	HYPH
cord-280549-bsnz24jx	48	27	type	type	NN
cord-280549-bsnz24jx	48	28	cyclin	cyclin	NN
cord-280549-bsnz24jx	48	29	and	and	CC
cord-280549-bsnz24jx	48	30	either	either	CC
cord-280549-bsnz24jx	48	31	CDK4	CDK4	NNP
cord-280549-bsnz24jx	48	32	or	or	CC
cord-280549-bsnz24jx	48	33	CDK6	CDK6	NNP
cord-280549-bsnz24jx	48	34	depending	depend	VBG
cord-280549-bsnz24jx	48	35	on	on	IN
cord-280549-bsnz24jx	48	36	the	the	DT
cord-280549-bsnz24jx	48	37	cell	cell	NN
cord-280549-bsnz24jx	48	38	type	type	NN
cord-280549-bsnz24jx	48	39	(	(	-LRB-
cord-280549-bsnz24jx	48	40	Matsushime	Matsushime	NNP
cord-280549-bsnz24jx	48	41	et	et	NNP
cord-280549-bsnz24jx	48	42	al	al	NNP
cord-280549-bsnz24jx	48	43	.	.	NNP
cord-280549-bsnz24jx	48	44	,	,	,
cord-280549-bsnz24jx	48	45	1994	1994	CD
cord-280549-bsnz24jx	48	46	)	)	-RRB-
cord-280549-bsnz24jx	48	47	.	.	.
cord-280549-bsnz24jx	49	1	Cyclin	Cyclin	NNP
cord-280549-bsnz24jx	49	2	D	d	NN
cord-280549-bsnz24jx	49	3	functions	function	NNS
cord-280549-bsnz24jx	49	4	as	as	IN
cord-280549-bsnz24jx	49	5	growth	growth	NN
cord-280549-bsnz24jx	49	6	factor	factor	NN
cord-280549-bsnz24jx	49	7	sensor	sensor	NN
cord-280549-bsnz24jx	49	8	,	,	,
cord-280549-bsnz24jx	50	1	the	the	DT
cord-280549-bsnz24jx	50	2	expression	expression	NN
cord-280549-bsnz24jx	50	3	of	of	IN
cord-280549-bsnz24jx	50	4	which	which	WDT
cord-280549-bsnz24jx	50	5	is	be	VBZ
cord-280549-bsnz24jx	50	6	stimulated	stimulate	VBN
cord-280549-bsnz24jx	50	7	by	by	IN
cord-280549-bsnz24jx	50	8	growth	growth	NN
cord-280549-bsnz24jx	50	9	factor	factor	NN
cord-280549-bsnz24jx	50	10	and	and	CC
cord-280549-bsnz24jx	50	11	is	be	VBZ
cord-280549-bsnz24jx	50	12	independent	independent	JJ
cord-280549-bsnz24jx	50	13	of	of	IN
cord-280549-bsnz24jx	50	14	the	the	DT
cord-280549-bsnz24jx	50	15	state	state	NN
cord-280549-bsnz24jx	50	16	of	of	IN
cord-280549-bsnz24jx	50	17	the	the	DT
cord-280549-bsnz24jx	50	18	cell	cell	NN
cord-280549-bsnz24jx	50	19	cycle	cycle	NN
cord-280549-bsnz24jx	50	20	(	(	-LRB-
cord-280549-bsnz24jx	50	21	Sherr	Sherr	NNP
cord-280549-bsnz24jx	50	22	,	,	,
cord-280549-bsnz24jx	50	23	1993	1993	CD
cord-280549-bsnz24jx	50	24	)	)	-RRB-
cord-280549-bsnz24jx	50	25	.	.	.
cord-280549-bsnz24jx	51	1	Knowledge	knowledge	NN
cord-280549-bsnz24jx	51	2	of	of	IN
cord-280549-bsnz24jx	51	3	the	the	DT
cord-280549-bsnz24jx	51	4	role	role	NN
cord-280549-bsnz24jx	51	5	of	of	IN
cord-280549-bsnz24jx	51	6	D	d	NN
cord-280549-bsnz24jx	51	7	-	-	HYPH
cord-280549-bsnz24jx	51	8	type	type	NN
cord-280549-bsnz24jx	51	9	cyclin	cyclin	NN
cord-280549-bsnz24jx	51	10	in	in	IN
cord-280549-bsnz24jx	51	11	G1	G1	NNP
cord-280549-bsnz24jx	51	12	progression	progression	NN
cord-280549-bsnz24jx	51	13	was	be	VBD
cord-280549-bsnz24jx	51	14	obtained	obtain	VBN
cord-280549-bsnz24jx	51	15	from	from	IN
cord-280549-bsnz24jx	51	16	the	the	DT
cord-280549-bsnz24jx	51	17	observation	observation	NN
cord-280549-bsnz24jx	51	18	that	that	IN
cord-280549-bsnz24jx	51	19	microinjection	microinjection	NN
cord-280549-bsnz24jx	51	20	of	of	IN
cord-280549-bsnz24jx	51	21	anti	anti	JJ
cord-280549-bsnz24jx	51	22	-	-	JJ
cord-280549-bsnz24jx	51	23	cyclin	cyclin	JJ
cord-280549-bsnz24jx	51	24	D1	d1	NN
cord-280549-bsnz24jx	51	25	antibodies	antibody	NNS
cord-280549-bsnz24jx	51	26	into	into	IN
cord-280549-bsnz24jx	51	27	fibroblasts	fibroblast	NNS
cord-280549-bsnz24jx	51	28	that	that	WDT
cord-280549-bsnz24jx	51	29	were	be	VBD
cord-280549-bsnz24jx	51	30	in	in	IN
cord-280549-bsnz24jx	51	31	G1	G1	NNP
cord-280549-bsnz24jx	51	32	phase	phase	NN
cord-280549-bsnz24jx	51	33	prevent	prevent	VB
cord-280549-bsnz24jx	51	34	them	-PRON-	PRP
cord-280549-bsnz24jx	51	35	from	from	IN
cord-280549-bsnz24jx	51	36	entering	enter	VBG
cord-280549-bsnz24jx	51	37	into	into	IN
cord-280549-bsnz24jx	51	38	S	s	NN
cord-280549-bsnz24jx	51	39	phase	phase	NN
cord-280549-bsnz24jx	52	1	(	(	-LRB-
cord-280549-bsnz24jx	52	2	Baldin	Baldin	NNP
cord-280549-bsnz24jx	52	3	et	et	NNP
cord-280549-bsnz24jx	52	4	al	al	NNP
cord-280549-bsnz24jx	52	5	.	.	NNP
cord-280549-bsnz24jx	52	6	,	,	,
cord-280549-bsnz24jx	52	7	1993	1993	CD
cord-280549-bsnz24jx	52	8	)	)	-RRB-
cord-280549-bsnz24jx	52	9	.	.	.
cord-280549-bsnz24jx	53	1	On	on	IN
cord-280549-bsnz24jx	53	2	the	the	DT
cord-280549-bsnz24jx	53	3	contrary	contrary	NN
cord-280549-bsnz24jx	53	4	,	,	,
cord-280549-bsnz24jx	53	5	overexpression	overexpression	NN
cord-280549-bsnz24jx	53	6	of	of	IN
cord-280549-bsnz24jx	53	7	cyclin	cyclin	NN
cord-280549-bsnz24jx	53	8	D1	d1	NN
cord-280549-bsnz24jx	53	9	shortens	shorten	VBZ
cord-280549-bsnz24jx	53	10	the	the	DT
cord-280549-bsnz24jx	53	11	duration	duration	NN
cord-280549-bsnz24jx	53	12	of	of	IN
cord-280549-bsnz24jx	53	13	G1	G1	NNP
cord-280549-bsnz24jx	53	14	phase	phase	NN
cord-280549-bsnz24jx	53	15	in	in	IN
cord-280549-bsnz24jx	53	16	mouse	mouse	NN
cord-280549-bsnz24jx	53	17	fibroblasts	fibroblast	NNS
cord-280549-bsnz24jx	53	18	,	,	,
cord-280549-bsnz24jx	53	19	demonstrating	demonstrate	VBG
cord-280549-bsnz24jx	53	20	cyclin	cyclin	NN
cord-280549-bsnz24jx	53	21	D1	d1	NN
cord-280549-bsnz24jx	53	22	is	be	VBZ
cord-280549-bsnz24jx	53	23	a	a	DT
cord-280549-bsnz24jx	53	24	rate	rate	NN
cord-280549-bsnz24jx	53	25	limiting	limit	VBG
cord-280549-bsnz24jx	53	26	factor	factor	NN
cord-280549-bsnz24jx	53	27	for	for	IN
cord-280549-bsnz24jx	53	28	G1	G1	NNP
cord-280549-bsnz24jx	53	29	progression	progression	NN
cord-280549-bsnz24jx	53	30	(	(	-LRB-
cord-280549-bsnz24jx	53	31	Quelle	Quelle	NNP
cord-280549-bsnz24jx	53	32	et	et	FW
cord-280549-bsnz24jx	53	33	al	al	NNP
cord-280549-bsnz24jx	53	34	.	.	NNP
cord-280549-bsnz24jx	53	35	,	,	,
cord-280549-bsnz24jx	53	36	1993	1993	CD
cord-280549-bsnz24jx	53	37	)	)	-RRB-
cord-280549-bsnz24jx	53	38	.	.	.
cord-280549-bsnz24jx	54	1	Assembly	Assembly	NNP
cord-280549-bsnz24jx	54	2	of	of	IN
cord-280549-bsnz24jx	54	3	cyclin	cyclin	NNP
cord-280549-bsnz24jx	54	4	D	D	NNP
cord-280549-bsnz24jx	54	5	-	-	HYPH
cord-280549-bsnz24jx	54	6	CDK4/6	cdk4/6	NN
cord-280549-bsnz24jx	55	1	complexes	complex	NNS
cord-280549-bsnz24jx	55	2	facilitates	facilitate	VBZ
cord-280549-bsnz24jx	55	3	the	the	DT
cord-280549-bsnz24jx	55	4	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	55	5	of	of	IN
cord-280549-bsnz24jx	55	6	CDK4/6	CDK4/6	.
cord-280549-bsnz24jx	56	1	by	by	IN
cord-280549-bsnz24jx	56	2	a	a	DT
cord-280549-bsnz24jx	56	3	CDK	CDK	NNP
cord-280549-bsnz24jx	56	4	-	-	HYPH
cord-280549-bsnz24jx	56	5	activating	activate	VBG
cord-280549-bsnz24jx	56	6	kinase	kinase	NN
cord-280549-bsnz24jx	56	7	(	(	-LRB-
cord-280549-bsnz24jx	56	8	CAK	CAK	NNP
cord-280549-bsnz24jx	56	9	)	)	-RRB-
cord-280549-bsnz24jx	56	10	,	,	,
cord-280549-bsnz24jx	56	11	which	which	WDT
cord-280549-bsnz24jx	56	12	is	be	VBZ
cord-280549-bsnz24jx	56	13	required	require	VBN
cord-280549-bsnz24jx	56	14	for	for	IN
cord-280549-bsnz24jx	56	15	the	the	DT
cord-280549-bsnz24jx	56	16	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	56	17	and	and	CC
cord-280549-bsnz24jx	56	18	enzymatic	enzymatic	JJ
cord-280549-bsnz24jx	56	19	activation	activation	NN
cord-280549-bsnz24jx	56	20	of	of	IN
cord-280549-bsnz24jx	56	21	CDKs	cdk	NNS
cord-280549-bsnz24jx	56	22	Kaldis	Kaldis	NNP
cord-280549-bsnz24jx	56	23	et	et	NNP
cord-280549-bsnz24jx	56	24	al	al	NNP
cord-280549-bsnz24jx	56	25	.	.	NNP
cord-280549-bsnz24jx	56	26	,	,	,
cord-280549-bsnz24jx	56	27	1998	1998	CD
cord-280549-bsnz24jx	56	28	)	)	-RRB-
cord-280549-bsnz24jx	56	29	.	.	.
cord-280549-bsnz24jx	57	1	CAK	CAK	NNP
cord-280549-bsnz24jx	57	2	is	be	VBZ
cord-280549-bsnz24jx	57	3	composed	compose	VBN
cord-280549-bsnz24jx	57	4	of	of	IN
cord-280549-bsnz24jx	57	5	three	three	CD
cord-280549-bsnz24jx	57	6	subunits	subunit	NNS
cord-280549-bsnz24jx	57	7	,	,	,
cord-280549-bsnz24jx	57	8	CDK7	CDK7	NNP
cord-280549-bsnz24jx	57	9	,	,	,
cord-280549-bsnz24jx	57	10	cyclin	cyclin	NN
cord-280549-bsnz24jx	57	11	H	H	NNP
cord-280549-bsnz24jx	57	12	and	and	CC
cord-280549-bsnz24jx	57	13	MAT1	MAT1	NNP
cord-280549-bsnz24jx	57	14	(	(	-LRB-
cord-280549-bsnz24jx	57	15	ménage	ménage	FW
cord-280549-bsnz24jx	57	16	à	à	FW
cord-280549-bsnz24jx	57	17	trois	trois	FW
cord-280549-bsnz24jx	57	18	)	)	-RRB-
cord-280549-bsnz24jx	57	19	(	(	-LRB-
cord-280549-bsnz24jx	57	20	Devault	Devault	NNP
cord-280549-bsnz24jx	57	21	et	et	NNP
cord-280549-bsnz24jx	57	22	al	al	NNP
cord-280549-bsnz24jx	57	23	.	.	NNP
cord-280549-bsnz24jx	57	24	,	,	,
cord-280549-bsnz24jx	57	25	1995	1995	CD
cord-280549-bsnz24jx	57	26	)	)	-RRB-
cord-280549-bsnz24jx	57	27	.	.	.
cord-280549-bsnz24jx	58	1	Specifically	specifically	RB
cord-280549-bsnz24jx	58	2	,	,	,
cord-280549-bsnz24jx	58	3	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	58	4	of	of	IN
cord-280549-bsnz24jx	58	5	CDKs	cdk	NNS
cord-280549-bsnz24jx	58	6	at	at	IN
cord-280549-bsnz24jx	58	7	Thr161/160/172	Thr161/160/172	NNP
cord-280549-bsnz24jx	58	8	by	by	IN
cord-280549-bsnz24jx	58	9	CAK	CAK	NNP
cord-280549-bsnz24jx	58	10	is	be	VBZ
cord-280549-bsnz24jx	58	11	essential	essential	JJ
cord-280549-bsnz24jx	58	12	for	for	IN
cord-280549-bsnz24jx	58	13	stabilization	stabilization	NN
cord-280549-bsnz24jx	58	14	of	of	IN
cord-280549-bsnz24jx	58	15	CDK	CDK	NNP
cord-280549-bsnz24jx	58	16	/	/	SYM
cord-280549-bsnz24jx	58	17	cyclin	cyclin	NN
cord-280549-bsnz24jx	58	18	complexes	complex	NNS
cord-280549-bsnz24jx	58	19	by	by	IN
cord-280549-bsnz24jx	58	20	inducing	induce	VBG
cord-280549-bsnz24jx	58	21	a	a	DT
cord-280549-bsnz24jx	58	22	conformational	conformational	JJ
cord-280549-bsnz24jx	58	23	change	change	NN
cord-280549-bsnz24jx	58	24	that	that	WDT
cord-280549-bsnz24jx	58	25	increases	increase	VBZ
cord-280549-bsnz24jx	58	26	the	the	DT
cord-280549-bsnz24jx	58	27	flexibility	flexibility	NN
cord-280549-bsnz24jx	58	28	of	of	IN
cord-280549-bsnz24jx	58	29	the	the	DT
cord-280549-bsnz24jx	58	30	T	T	NNP
cord-280549-bsnz24jx	58	31	-	-	HYPH
cord-280549-bsnz24jx	58	32	loops	loop	NNS
cord-280549-bsnz24jx	58	33	of	of	IN
cord-280549-bsnz24jx	58	34	all	all	DT
cord-280549-bsnz24jx	58	35	CDKs	cdk	NNS
cord-280549-bsnz24jx	58	36	tested	test	VBD
cord-280549-bsnz24jx	58	37	and	and	CC
cord-280549-bsnz24jx	58	38	enables	enable	VBZ
cord-280549-bsnz24jx	58	39	access	access	NN
cord-280549-bsnz24jx	58	40	of	of	IN
cord-280549-bsnz24jx	58	41	the	the	DT
cord-280549-bsnz24jx	58	42	cyclin	cyclin	NN
cord-280549-bsnz24jx	58	43	substrate	substrate	NN
cord-280549-bsnz24jx	58	44	Brown	Brown	NNP
cord-280549-bsnz24jx	58	45	et	et	NNP
cord-280549-bsnz24jx	58	46	al	al	NNP
cord-280549-bsnz24jx	58	47	.	.	NNP
cord-280549-bsnz24jx	58	48	,	,	,
cord-280549-bsnz24jx	58	49	1999	1999	CD
cord-280549-bsnz24jx	58	50	;	;	:
cord-280549-bsnz24jx	59	1	Morris	Morris	NNP
cord-280549-bsnz24jx	59	2	et	et	NNP
cord-280549-bsnz24jx	59	3	al	al	NNP
cord-280549-bsnz24jx	59	4	.	.	NNP
cord-280549-bsnz24jx	59	5	,	,	,
cord-280549-bsnz24jx	59	6	2002	2002	CD
cord-280549-bsnz24jx	59	7	)	)	-RRB-
cord-280549-bsnz24jx	59	8	.	.	.
cord-280549-bsnz24jx	60	1	Activated	activate	VBN
cord-280549-bsnz24jx	60	2	cyclin	cyclin	NN
cord-280549-bsnz24jx	60	3	D	D	NNP
cord-280549-bsnz24jx	60	4	-	-	HYPH
cord-280549-bsnz24jx	60	5	CDK4/6	cdk4/6	NN
cord-280549-bsnz24jx	61	1	complexes	complex	NNS
cord-280549-bsnz24jx	61	2	phosphorylate	phosphorylate	VBP
cord-280549-bsnz24jx	61	3	Rb	Rb	NNP
cord-280549-bsnz24jx	61	4	,	,	,
cord-280549-bsnz24jx	61	5	which	which	WDT
cord-280549-bsnz24jx	61	6	gets	get	VBZ
cord-280549-bsnz24jx	61	7	further	further	RB
cord-280549-bsnz24jx	61	8	phosphorylated	phosphorylate	VBN
cord-280549-bsnz24jx	61	9	by	by	IN
cord-280549-bsnz24jx	61	10	cyclin	cyclin	NN
cord-280549-bsnz24jx	61	11	E	E	NNP
cord-280549-bsnz24jx	61	12	-	-	JJ
cord-280549-bsnz24jx	61	13	CDK2	cdk2	JJ
cord-280549-bsnz24jx	61	14	complex	complex	NN
cord-280549-bsnz24jx	61	15	at	at	IN
cord-280549-bsnz24jx	61	16	the	the	DT
cord-280549-bsnz24jx	61	17	mid	mid	NN
cord-280549-bsnz24jx	61	18	-	-	HYPH
cord-280549-bsnz24jx	61	19	to	to	IN
cord-280549-bsnz24jx	61	20	-	-	HYPH
cord-280549-bsnz24jx	61	21	late	late	JJ
cord-280549-bsnz24jx	61	22	G1	G1	NNP
cord-280549-bsnz24jx	61	23	phase	phase	NN
cord-280549-bsnz24jx	61	24	.	.	.
cord-280549-bsnz24jx	62	1	Hyperphosphorylation	Hyperphosphorylation	NNP
cord-280549-bsnz24jx	62	2	inactivates	inactivate	VBZ
cord-280549-bsnz24jx	62	3	Rb	Rb	NNP
cord-280549-bsnz24jx	62	4	and	and	CC
cord-280549-bsnz24jx	62	5	leads	lead	VBZ
cord-280549-bsnz24jx	62	6	to	to	IN
cord-280549-bsnz24jx	62	7	the	the	DT
cord-280549-bsnz24jx	62	8	release	release	NN
cord-280549-bsnz24jx	62	9	of	of	IN
cord-280549-bsnz24jx	62	10	transcription	transcription	NN
cord-280549-bsnz24jx	62	11	factor	factor	NN
cord-280549-bsnz24jx	62	12	E2F	e2f	NN
cord-280549-bsnz24jx	62	13	,	,	,
cord-280549-bsnz24jx	62	14	which	which	WDT
cord-280549-bsnz24jx	62	15	activates	activate	VBZ
cord-280549-bsnz24jx	62	16	the	the	DT
cord-280549-bsnz24jx	62	17	transcription	transcription	NN
cord-280549-bsnz24jx	62	18	of	of	IN
cord-280549-bsnz24jx	62	19	other	other	JJ
cord-280549-bsnz24jx	62	20	cell	cell	NN
cord-280549-bsnz24jx	62	21	cycle	cycle	NN
cord-280549-bsnz24jx	62	22	promoting	promote	VBG
cord-280549-bsnz24jx	62	23	genes	gene	NNS
cord-280549-bsnz24jx	62	24	,	,	,
cord-280549-bsnz24jx	62	25	from	from	IN
cord-280549-bsnz24jx	62	26	the	the	DT
cord-280549-bsnz24jx	62	27	blocking	block	VBG
cord-280549-bsnz24jx	62	28	effect	effect	NN
cord-280549-bsnz24jx	62	29	imposed	impose	VBN
cord-280549-bsnz24jx	62	30	by	by	IN
cord-280549-bsnz24jx	62	31	hypophosphorylated	hypophosphorylated	JJ
cord-280549-bsnz24jx	62	32	Rb	Rb	NNP
cord-280549-bsnz24jx	62	33	(	(	-LRB-
cord-280549-bsnz24jx	62	34	Ewen	Ewen	NNP
cord-280549-bsnz24jx	62	35	et	et	NNP
cord-280549-bsnz24jx	62	36	al	al	NNP
cord-280549-bsnz24jx	62	37	.	.	NNP
cord-280549-bsnz24jx	62	38	,	,	,
cord-280549-bsnz24jx	62	39	1993	1993	CD
cord-280549-bsnz24jx	62	40	;	;	:
cord-280549-bsnz24jx	62	41	Weinberg	Weinberg	NNP
cord-280549-bsnz24jx	62	42	,	,	,
cord-280549-bsnz24jx	62	43	1995	1995	CD
cord-280549-bsnz24jx	62	44	)	)	-RRB-
cord-280549-bsnz24jx	62	45	.	.	.
cord-280549-bsnz24jx	63	1	From	from	IN
cord-280549-bsnz24jx	63	2	this	this	DT
cord-280549-bsnz24jx	63	3	time	time	NN
cord-280549-bsnz24jx	63	4	on	on	IN
cord-280549-bsnz24jx	63	5	,	,	,
cord-280549-bsnz24jx	63	6	cell	cell	NN
cord-280549-bsnz24jx	63	7	cycle	cycle	NN
cord-280549-bsnz24jx	63	8	becomes	become	VBZ
cord-280549-bsnz24jx	63	9	independent	independent	JJ
cord-280549-bsnz24jx	63	10	of	of	IN
cord-280549-bsnz24jx	63	11	growth	growth	NN
cord-280549-bsnz24jx	63	12	factor	factor	NN
cord-280549-bsnz24jx	63	13	stimulation	stimulation	NN
cord-280549-bsnz24jx	63	14	for	for	IN
cord-280549-bsnz24jx	63	15	continued	continued	JJ
cord-280549-bsnz24jx	63	16	cell	cell	NN
cord-280549-bsnz24jx	63	17	cycle	cycle	NN
cord-280549-bsnz24jx	63	18	progression	progression	NN
cord-280549-bsnz24jx	63	19	.	.	.
cord-280549-bsnz24jx	64	1	Further	further	JJ
cord-280549-bsnz24jx	64	2	progression	progression	NN
cord-280549-bsnz24jx	64	3	into	into	IN
cord-280549-bsnz24jx	64	4	S	s	NN
cord-280549-bsnz24jx	64	5	phase	phase	NN
cord-280549-bsnz24jx	64	6	is	be	VBZ
cord-280549-bsnz24jx	64	7	driven	drive	VBN
cord-280549-bsnz24jx	64	8	by	by	IN
cord-280549-bsnz24jx	64	9	cyclin	cyclin	NN
cord-280549-bsnz24jx	64	10	E	E	NNP
cord-280549-bsnz24jx	64	11	-	-	NNP
cord-280549-bsnz24jx	64	12	CDK2	CDK2	NNP
cord-280549-bsnz24jx	64	13	,	,	,
cord-280549-bsnz24jx	64	14	and	and	CC
cord-280549-bsnz24jx	64	15	thereafter	thereafter	RB
cord-280549-bsnz24jx	64	16	cyclin	cyclin	NNP
cord-280549-bsnz24jx	64	17	A	A	NNP
cord-280549-bsnz24jx	64	18	-	-	HYPH
cord-280549-bsnz24jx	64	19	CDK2	CDK2	NNP
cord-280549-bsnz24jx	64	20	promotes	promote	VBZ
cord-280549-bsnz24jx	64	21	the	the	DT
cord-280549-bsnz24jx	64	22	completion	completion	NN
cord-280549-bsnz24jx	64	23	of	of	IN
cord-280549-bsnz24jx	64	24	S	S	NNP
cord-280549-bsnz24jx	64	25	phase	phase	NN
cord-280549-bsnz24jx	64	26	.	.	.
cord-280549-bsnz24jx	65	1	The	the	DT
cord-280549-bsnz24jx	65	2	precise	precise	JJ
cord-280549-bsnz24jx	65	3	role	role	NN
cord-280549-bsnz24jx	65	4	cyclin	cyclin	NN
cord-280549-bsnz24jx	65	5	-	-	HYPH
cord-280549-bsnz24jx	65	6	CDK	CDK	NNP
cord-280549-bsnz24jx	65	7	complexes	complex	NNS
cord-280549-bsnz24jx	65	8	play	play	VBP
cord-280549-bsnz24jx	65	9	in	in	IN
cord-280549-bsnz24jx	65	10	the	the	DT
cord-280549-bsnz24jx	65	11	control	control	NN
cord-280549-bsnz24jx	65	12	of	of	IN
cord-280549-bsnz24jx	65	13	DNA	dna	NN
cord-280549-bsnz24jx	65	14	replication	replication	NN
cord-280549-bsnz24jx	65	15	is	be	VBZ
cord-280549-bsnz24jx	65	16	poorly	poorly	RB
cord-280549-bsnz24jx	65	17	defined	define	VBN
cord-280549-bsnz24jx	65	18	.	.	.
cord-280549-bsnz24jx	66	1	It	-PRON-	PRP
cord-280549-bsnz24jx	66	2	appears	appear	VBZ
cord-280549-bsnz24jx	66	3	that	that	IN
cord-280549-bsnz24jx	66	4	cyclin	cyclin	NN
cord-280549-bsnz24jx	66	5	E	E	NNP
cord-280549-bsnz24jx	66	6	-	-	NNP
cord-280549-bsnz24jx	66	7	CDK2	CDK2	NNP
cord-280549-bsnz24jx	66	8	is	be	VBZ
cord-280549-bsnz24jx	66	9	involved	involve	VBN
cord-280549-bsnz24jx	66	10	in	in	IN
cord-280549-bsnz24jx	66	11	centrosome	centrosome	NN
cord-280549-bsnz24jx	66	12	duplication	duplication	NN
cord-280549-bsnz24jx	66	13	(	(	-LRB-
cord-280549-bsnz24jx	66	14	Lacey	Lacey	NNP
cord-280549-bsnz24jx	66	15	et	et	NNP
cord-280549-bsnz24jx	66	16	al	al	NNP
cord-280549-bsnz24jx	66	17	.	.	NNP
cord-280549-bsnz24jx	66	18	,	,	,
cord-280549-bsnz24jx	66	19	1999	1999	CD
cord-280549-bsnz24jx	66	20	)	)	-RRB-
cord-280549-bsnz24jx	66	21	,	,	,
cord-280549-bsnz24jx	66	22	and	and	CC
cord-280549-bsnz24jx	66	23	CDK2	CDK2	NNP
cord-280549-bsnz24jx	66	24	is	be	VBZ
cord-280549-bsnz24jx	66	25	necessary	necessary	JJ
cord-280549-bsnz24jx	66	26	for	for	IN
cord-280549-bsnz24jx	66	27	DNA	dna	NN
cord-280549-bsnz24jx	66	28	replication	replication	NN
cord-280549-bsnz24jx	66	29	in	in	IN
cord-280549-bsnz24jx	66	30	a	a	DT
cord-280549-bsnz24jx	66	31	cell	cell	NN
cord-280549-bsnz24jx	66	32	-	-	HYPH
cord-280549-bsnz24jx	66	33	free	free	JJ
cord-280549-bsnz24jx	66	34	system	system	NN
cord-280549-bsnz24jx	67	1	(	(	-LRB-
cord-280549-bsnz24jx	67	2	Krude	Krude	NNP
cord-280549-bsnz24jx	67	3	et	et	FW
cord-280549-bsnz24jx	67	4	al	al	NNP
cord-280549-bsnz24jx	67	5	.	.	NNP
cord-280549-bsnz24jx	67	6	,	,	,
cord-280549-bsnz24jx	67	7	1997	1997	CD
cord-280549-bsnz24jx	67	8	)	)	-RRB-
cord-280549-bsnz24jx	67	9	.	.	.
cord-280549-bsnz24jx	68	1	Following	follow	VBG
cord-280549-bsnz24jx	68	2	DNA	dna	NN
cord-280549-bsnz24jx	68	3	synthesis	synthesis	NN
cord-280549-bsnz24jx	68	4	,	,	,
cord-280549-bsnz24jx	68	5	cells	cell	NNS
cord-280549-bsnz24jx	68	6	enter	enter	VBP
cord-280549-bsnz24jx	68	7	into	into	IN
cord-280549-bsnz24jx	68	8	G2	G2	NNP
cord-280549-bsnz24jx	68	9	phase	phase	NN
cord-280549-bsnz24jx	68	10	and	and	CC
cord-280549-bsnz24jx	68	11	CDK1	CDK1	NNP
cord-280549-bsnz24jx	68	12	is	be	VBZ
cord-280549-bsnz24jx	68	13	believed	believe	VBN
cord-280549-bsnz24jx	68	14	to	to	TO
cord-280549-bsnz24jx	68	15	catalyze	catalyze	VB
cord-280549-bsnz24jx	68	16	events	event	NNS
cord-280549-bsnz24jx	68	17	in	in	IN
cord-280549-bsnz24jx	68	18	G2	G2	NNP
cord-280549-bsnz24jx	68	19	/	/	SYM
cord-280549-bsnz24jx	68	20	M	M	NNP
cord-280549-bsnz24jx	68	21	phase	phase	NN
cord-280549-bsnz24jx	68	22	through	through	IN
cord-280549-bsnz24jx	68	23	sequential	sequential	JJ
cord-280549-bsnz24jx	68	24	association	association	NN
cord-280549-bsnz24jx	68	25	with	with	IN
cord-280549-bsnz24jx	68	26	cyclin	cyclin	NNP
cord-280549-bsnz24jx	68	27	A	A	NNP
cord-280549-bsnz24jx	68	28	and	and	CC
cord-280549-bsnz24jx	69	1	cyclin	cyclin	NNP
cord-280549-bsnz24jx	69	2	B.	B.	NNP
cord-280549-bsnz24jx	70	1	It	-PRON-	PRP
cord-280549-bsnz24jx	70	2	is	be	VBZ
cord-280549-bsnz24jx	70	3	reported	report	VBN
cord-280549-bsnz24jx	70	4	that	that	IN
cord-280549-bsnz24jx	70	5	the	the	DT
cord-280549-bsnz24jx	70	6	complexing	complexing	NN
cord-280549-bsnz24jx	70	7	of	of	IN
cord-280549-bsnz24jx	70	8	both	both	DT
cord-280549-bsnz24jx	70	9	cyclin	cyclin	NN
cord-280549-bsnz24jx	70	10	A	A	NNP
cord-280549-bsnz24jx	70	11	-	-	:
cord-280549-bsnz24jx	70	12	CDK2	CDK2	NNP
cord-280549-bsnz24jx	70	13	in	in	IN
cord-280549-bsnz24jx	70	14	late	late	JJ
cord-280549-bsnz24jx	70	15	S	S	NNP
cord-280549-bsnz24jx	70	16	phase	phase	NN
cord-280549-bsnz24jx	70	17	and	and	CC
cord-280549-bsnz24jx	70	18	cyclin	cyclin	NN
cord-280549-bsnz24jx	70	19	A	A	NNP
cord-280549-bsnz24jx	70	20	-	-	HYPH
cord-280549-bsnz24jx	70	21	CDK1	CDK1	NNP
cord-280549-bsnz24jx	70	22	in	in	IN
cord-280549-bsnz24jx	70	23	G2	G2	NNP
cord-280549-bsnz24jx	70	24	/	/	SYM
cord-280549-bsnz24jx	70	25	M	M	NNP
cord-280549-bsnz24jx	70	26	phase	phase	NN
cord-280549-bsnz24jx	70	27	inactivate	inactivate	VBP
cord-280549-bsnz24jx	70	28	anaphase	anaphase	NN
cord-280549-bsnz24jx	70	29	promoting	promote	VBG
cord-280549-bsnz24jx	70	30	complex	complex	JJ
cord-280549-bsnz24jx	70	31	/	/	SYM
cord-280549-bsnz24jx	70	32	cyclosome	cyclosome	NNP
cord-280549-bsnz24jx	70	33	(	(	-LRB-
cord-280549-bsnz24jx	70	34	APC	APC	NNP
cord-280549-bsnz24jx	70	35	/	/	SYM
cord-280549-bsnz24jx	70	36	C	C	NNP
cord-280549-bsnz24jx	70	37	)	)	-RRB-
cord-280549-bsnz24jx	70	38	to	to	TO
cord-280549-bsnz24jx	70	39	ensure	ensure	VB
cord-280549-bsnz24jx	70	40	accumulation	accumulation	NN
cord-280549-bsnz24jx	70	41	of	of	IN
cord-280549-bsnz24jx	70	42	key	key	JJ
cord-280549-bsnz24jx	70	43	mitotic	mitotic	JJ
cord-280549-bsnz24jx	70	44	regulators	regulator	NNS
cord-280549-bsnz24jx	70	45	(	(	-LRB-
cord-280549-bsnz24jx	70	46	Mitra	Mitra	NNP
cord-280549-bsnz24jx	70	47	et	et	FW
cord-280549-bsnz24jx	70	48	al	al	NNP
cord-280549-bsnz24jx	70	49	.	.	NNP
cord-280549-bsnz24jx	70	50	,	,	,
cord-280549-bsnz24jx	70	51	2006	2006	CD
cord-280549-bsnz24jx	70	52	)	)	-RRB-
cord-280549-bsnz24jx	70	53	.	.	.
cord-280549-bsnz24jx	71	1	Maturation	Maturation	NNP
cord-280549-bsnz24jx	71	2	/	/	SYM
cord-280549-bsnz24jx	71	3	M	M	NNP
cord-280549-bsnz24jx	71	4	phase	phase	NN
cord-280549-bsnz24jx	71	5	-	-	HYPH
cord-280549-bsnz24jx	71	6	promoting	promote	VBG
cord-280549-bsnz24jx	71	7	factor	factor	NN
cord-280549-bsnz24jx	71	8	(	(	-LRB-
cord-280549-bsnz24jx	71	9	MPF	MPF	NNP
cord-280549-bsnz24jx	71	10	)	)	-RRB-
cord-280549-bsnz24jx	71	11	refers	refer	VBZ
cord-280549-bsnz24jx	71	12	to	to	IN
cord-280549-bsnz24jx	71	13	the	the	DT
cord-280549-bsnz24jx	71	14	universal	universal	JJ
cord-280549-bsnz24jx	71	15	inducer	inducer	NN
cord-280549-bsnz24jx	71	16	of	of	IN
cord-280549-bsnz24jx	71	17	entry	entry	NN
cord-280549-bsnz24jx	71	18	into	into	IN
cord-280549-bsnz24jx	71	19	M	M	NNP
cord-280549-bsnz24jx	71	20	phase	phase	NN
cord-280549-bsnz24jx	71	21	in	in	IN
cord-280549-bsnz24jx	71	22	eukaryotic	eukaryotic	JJ
cord-280549-bsnz24jx	71	23	cell	cell	NN
cord-280549-bsnz24jx	71	24	.	.	.
cord-280549-bsnz24jx	72	1	Cyclin	Cyclin	NNP
cord-280549-bsnz24jx	72	2	B	B	NNP
cord-280549-bsnz24jx	72	3	-	-	HYPH
cord-280549-bsnz24jx	72	4	CDK1	CDK1	NNP
cord-280549-bsnz24jx	72	5	is	be	VBZ
cord-280549-bsnz24jx	72	6	one	one	CD
cord-280549-bsnz24jx	72	7	major	major	JJ
cord-280549-bsnz24jx	72	8	component	component	NN
cord-280549-bsnz24jx	72	9	of	of	IN
cord-280549-bsnz24jx	72	10	the	the	DT
cord-280549-bsnz24jx	72	11	MPF	MPF	NNP
cord-280549-bsnz24jx	72	12	complex	complex	NN
cord-280549-bsnz24jx	72	13	(	(	-LRB-
cord-280549-bsnz24jx	72	14	Hunt	hunt	NN
cord-280549-bsnz24jx	72	15	,	,	,
cord-280549-bsnz24jx	72	16	1989	1989	CD
cord-280549-bsnz24jx	72	17	;	;	:
cord-280549-bsnz24jx	72	18	Nurse	nurse	NN
cord-280549-bsnz24jx	72	19	,	,	,
cord-280549-bsnz24jx	72	20	1990	1990	CD
cord-280549-bsnz24jx	72	21	)	)	-RRB-
cord-280549-bsnz24jx	72	22	.	.	.
cord-280549-bsnz24jx	73	1	Purified	purify	VBN
cord-280549-bsnz24jx	73	2	cyclin	cyclin	NN
cord-280549-bsnz24jx	73	3	B	B	NNP
cord-280549-bsnz24jx	73	4	-	-	HYPH
cord-280549-bsnz24jx	73	5	CDK1	CDK1	NNP
cord-280549-bsnz24jx	73	6	can	can	MD
cord-280549-bsnz24jx	73	7	induce	induce	VB
cord-280549-bsnz24jx	73	8	meiotic	meiotic	JJ
cord-280549-bsnz24jx	73	9	G2	G2	NNP
cord-280549-bsnz24jx	73	10	/	/	SYM
cord-280549-bsnz24jx	73	11	M	M	NNP
cord-280549-bsnz24jx	73	12	transition	transition	NN
cord-280549-bsnz24jx	73	13	upon	upon	IN
cord-280549-bsnz24jx	73	14	injection	injection	NN
cord-280549-bsnz24jx	73	15	into	into	IN
cord-280549-bsnz24jx	73	16	immature	immature	JJ
cord-280549-bsnz24jx	73	17	oocytes	oocyte	NNS
cord-280549-bsnz24jx	73	18	(	(	-LRB-
cord-280549-bsnz24jx	73	19	Lohka	Lohka	NNP
cord-280549-bsnz24jx	73	20	et	et	FW
cord-280549-bsnz24jx	73	21	al	al	NNP
cord-280549-bsnz24jx	73	22	.	.	NNP
cord-280549-bsnz24jx	73	23	,	,	,
cord-280549-bsnz24jx	73	24	1988	1988	CD
cord-280549-bsnz24jx	73	25	)	)	-RRB-
cord-280549-bsnz24jx	73	26	.	.	.
cord-280549-bsnz24jx	74	1	Proteins	protein	NNS
cord-280549-bsnz24jx	74	2	that	that	WDT
cord-280549-bsnz24jx	74	3	regulate	regulate	VBP
cord-280549-bsnz24jx	74	4	chromosomal	chromosomal	JJ
cord-280549-bsnz24jx	74	5	condensation	condensation	NN
cord-280549-bsnz24jx	74	6	,	,	,
cord-280549-bsnz24jx	74	7	formation	formation	NN
cord-280549-bsnz24jx	74	8	of	of	IN
cord-280549-bsnz24jx	74	9	mitotic	mitotic	JJ
cord-280549-bsnz24jx	74	10	spindles	spindle	NNS
cord-280549-bsnz24jx	74	11	,	,	,
cord-280549-bsnz24jx	74	12	and	and	CC
cord-280549-bsnz24jx	74	13	fragmentation	fragmentation	NN
cord-280549-bsnz24jx	74	14	of	of	IN
cord-280549-bsnz24jx	74	15	the	the	DT
cord-280549-bsnz24jx	74	16	Golgi	Golgi	NNP
cord-280549-bsnz24jx	74	17	apparatus	apparatus	NN
cord-280549-bsnz24jx	74	18	become	become	VBP
cord-280549-bsnz24jx	74	19	the	the	DT
cord-280549-bsnz24jx	74	20	substrates	substrate	NNS
cord-280549-bsnz24jx	74	21	of	of	IN
cord-280549-bsnz24jx	74	22	CDK1	CDK1	NNP
cord-280549-bsnz24jx	74	23	during	during	IN
cord-280549-bsnz24jx	74	24	M	M	NNP
cord-280549-bsnz24jx	74	25	phase	phase	NN
cord-280549-bsnz24jx	74	26	,	,	,
cord-280549-bsnz24jx	74	27	underscoring	underscore	VBG
cord-280549-bsnz24jx	74	28	the	the	DT
cord-280549-bsnz24jx	74	29	importance	importance	NN
cord-280549-bsnz24jx	74	30	of	of	IN
cord-280549-bsnz24jx	74	31	cyclin	cyclin	NN
cord-280549-bsnz24jx	74	32	B	B	NNP
cord-280549-bsnz24jx	74	33	-	-	HYPH
cord-280549-bsnz24jx	74	34	CDK1	CDK1	NNP
cord-280549-bsnz24jx	74	35	complex	complex	NN
cord-280549-bsnz24jx	75	1	(	(	-LRB-
cord-280549-bsnz24jx	75	2	Lowe	Lowe	NNP
cord-280549-bsnz24jx	75	3	et	et	NNP
cord-280549-bsnz24jx	75	4	al	al	NNP
cord-280549-bsnz24jx	75	5	.	.	NNP
cord-280549-bsnz24jx	75	6	,	,	,
cord-280549-bsnz24jx	75	7	1998	1998	CD
cord-280549-bsnz24jx	75	8	)	)	-RRB-
cord-280549-bsnz24jx	75	9	.	.	.
cord-280549-bsnz24jx	76	1	Study	study	VB
cord-280549-bsnz24jx	76	2	with	with	IN
cord-280549-bsnz24jx	76	3	CDK	CDK	NNP
cord-280549-bsnz24jx	76	4	or	or	CC
cord-280549-bsnz24jx	76	5	cyclin	cyclin	JJ
cord-280549-bsnz24jx	76	6	knockout	knockout	NN
cord-280549-bsnz24jx	76	7	mice	mouse	NNS
cord-280549-bsnz24jx	76	8	challenged	challenge	VBD
cord-280549-bsnz24jx	76	9	the	the	DT
cord-280549-bsnz24jx	76	10	traditional	traditional	JJ
cord-280549-bsnz24jx	76	11	orderly	orderly	JJ
cord-280549-bsnz24jx	76	12	scheme	scheme	NN
cord-280549-bsnz24jx	76	13	of	of	IN
cord-280549-bsnz24jx	76	14	cell	cell	NN
cord-280549-bsnz24jx	76	15	cycle	cycle	NN
cord-280549-bsnz24jx	76	16	progression	progression	NN
cord-280549-bsnz24jx	76	17	described	describe	VBN
cord-280549-bsnz24jx	76	18	above	above	RB
cord-280549-bsnz24jx	76	19	.	.	.
cord-280549-bsnz24jx	77	1	Mice	mouse	NNS
cord-280549-bsnz24jx	77	2	survive	survive	VBP
cord-280549-bsnz24jx	77	3	in	in	IN
cord-280549-bsnz24jx	77	4	the	the	DT
cord-280549-bsnz24jx	77	5	absence	absence	NN
cord-280549-bsnz24jx	77	6	of	of	IN
cord-280549-bsnz24jx	77	7	individual	individual	JJ
cord-280549-bsnz24jx	77	8	interface	interface	NN
cord-280549-bsnz24jx	77	9	CDKs	cdk	NNS
cord-280549-bsnz24jx	77	10	(	(	-LRB-
cord-280549-bsnz24jx	77	11	Rane	Rane	NNP
cord-280549-bsnz24jx	77	12	et	et	NNP
cord-280549-bsnz24jx	77	13	al	al	NNP
cord-280549-bsnz24jx	77	14	.	.	NNP
cord-280549-bsnz24jx	77	15	,	,	,
cord-280549-bsnz24jx	77	16	1999	1999	CD
cord-280549-bsnz24jx	77	17	;	;	:
cord-280549-bsnz24jx	77	18	Tsutsui	Tsutsui	NNP
cord-280549-bsnz24jx	77	19	et	et	FW
cord-280549-bsnz24jx	77	20	al	al	NNP
cord-280549-bsnz24jx	77	21	.	.	NNP
cord-280549-bsnz24jx	77	22	,	,	,
cord-280549-bsnz24jx	77	23	1999	1999	CD
cord-280549-bsnz24jx	77	24	;	;	:
cord-280549-bsnz24jx	78	1	Ye	Ye	NNP
cord-280549-bsnz24jx	78	2	et	et	NNP
cord-280549-bsnz24jx	78	3	al	al	NNP
cord-280549-bsnz24jx	78	4	.	.	.
cord-280549-bsnz24jx	79	1	,	,	,
cord-280549-bsnz24jx	79	2	2001	2001	CD
cord-280549-bsnz24jx	79	3	;	;	:
cord-280549-bsnz24jx	79	4	Berthet	Berthet	NNP
cord-280549-bsnz24jx	79	5	et	et	NNP
cord-280549-bsnz24jx	79	6	al	al	NNP
cord-280549-bsnz24jx	79	7	.	.	NNP
cord-280549-bsnz24jx	79	8	,	,	,
cord-280549-bsnz24jx	79	9	2003	2003	CD
cord-280549-bsnz24jx	79	10	;	;	:
cord-280549-bsnz24jx	79	11	Malumbres	Malumbres	NNP
cord-280549-bsnz24jx	79	12	et	et	NNP
cord-280549-bsnz24jx	79	13	al	al	NNP
cord-280549-bsnz24jx	79	14	.	.	NNP
cord-280549-bsnz24jx	79	15	,	,	,
cord-280549-bsnz24jx	79	16	2004	2004	CD
cord-280549-bsnz24jx	79	17	)	)	-RRB-
cord-280549-bsnz24jx	79	18	,	,	,
cord-280549-bsnz24jx	79	19	and	and	CC
cord-280549-bsnz24jx	79	20	similar	similar	JJ
cord-280549-bsnz24jx	79	21	results	result	NNS
cord-280549-bsnz24jx	79	22	have	have	VBP
cord-280549-bsnz24jx	79	23	been	be	VBN
cord-280549-bsnz24jx	79	24	obtained	obtain	VBN
cord-280549-bsnz24jx	79	25	on	on	IN
cord-280549-bsnz24jx	79	26	ablation	ablation	NN
cord-280549-bsnz24jx	79	27	of	of	IN
cord-280549-bsnz24jx	79	28	cyclin	cyclin	NN
cord-280549-bsnz24jx	79	29	D	d	NN
cord-280549-bsnz24jx	79	30	and	and	CC
cord-280549-bsnz24jx	79	31	cyclin	cyclin	NN
cord-280549-bsnz24jx	79	32	E	e	NN
cord-280549-bsnz24jx	79	33	(	(	-LRB-
cord-280549-bsnz24jx	79	34	Geng	Geng	NNP
cord-280549-bsnz24jx	79	35	et	et	FW
cord-280549-bsnz24jx	79	36	al	al	NNP
cord-280549-bsnz24jx	79	37	.	.	NNP
cord-280549-bsnz24jx	79	38	,	,	,
cord-280549-bsnz24jx	79	39	2003	2003	CD
cord-280549-bsnz24jx	79	40	;	;	:
cord-280549-bsnz24jx	80	1	Kozar	Kozar	NNP
cord-280549-bsnz24jx	80	2	et	et	NNP
cord-280549-bsnz24jx	80	3	al	al	NNP
cord-280549-bsnz24jx	80	4	.	.	NNP
cord-280549-bsnz24jx	80	5	,	,	,
cord-280549-bsnz24jx	80	6	2004	2004	CD
cord-280549-bsnz24jx	80	7	)	)	-RRB-
cord-280549-bsnz24jx	80	8	.	.	.
cord-280549-bsnz24jx	81	1	It	-PRON-	PRP
cord-280549-bsnz24jx	81	2	has	have	VBZ
cord-280549-bsnz24jx	81	3	been	be	VBN
cord-280549-bsnz24jx	81	4	shown	show	VBN
cord-280549-bsnz24jx	81	5	that	that	IN
cord-280549-bsnz24jx	81	6	CDK4	CDK4	NNP
cord-280549-bsnz24jx	81	7	and	and	CC
cord-280549-bsnz24jx	81	8	CDK6	CDK6	NNP
cord-280549-bsnz24jx	81	9	partner	partner	NN
cord-280549-bsnz24jx	81	10	only	only	RB
cord-280549-bsnz24jx	81	11	D	d	NN
cord-280549-bsnz24jx	81	12	-	-	HYPH
cord-280549-bsnz24jx	81	13	type	type	NN
cord-280549-bsnz24jx	81	14	cyclins	cyclin	NNS
cord-280549-bsnz24jx	81	15	,	,	,
cord-280549-bsnz24jx	81	16	whereas	whereas	IN
cord-280549-bsnz24jx	81	17	both	both	CC
cord-280549-bsnz24jx	81	18	CDK1	CDK1	NNP
cord-280549-bsnz24jx	81	19	and	and	CC
cord-280549-bsnz24jx	81	20	CDK2	CDK2	NNP
cord-280549-bsnz24jx	81	21	show	show	VBP
cord-280549-bsnz24jx	81	22	promiscuity	promiscuity	NN
cord-280549-bsnz24jx	81	23	in	in	IN
cord-280549-bsnz24jx	81	24	their	-PRON-	PRP$
cord-280549-bsnz24jx	81	25	choice	choice	NN
cord-280549-bsnz24jx	81	26	of	of	IN
cord-280549-bsnz24jx	81	27	cyclin	cyclin	NN
cord-280549-bsnz24jx	81	28	partners	partner	NNS
cord-280549-bsnz24jx	81	29	and	and	CC
cord-280549-bsnz24jx	81	30	exhibit	exhibit	VB
cord-280549-bsnz24jx	81	31	binding	bind	VBG
cord-280549-bsnz24jx	81	32	ability	ability	NN
cord-280549-bsnz24jx	81	33	with	with	IN
cord-280549-bsnz24jx	81	34	cyclin	cyclin	NN
cord-280549-bsnz24jx	81	35	A	A	NNP
cord-280549-bsnz24jx	81	36	,	,	,
cord-280549-bsnz24jx	81	37	B	b	NN
cord-280549-bsnz24jx	81	38	,	,	,
cord-280549-bsnz24jx	81	39	D	D	NNP
cord-280549-bsnz24jx	81	40	,	,	,
cord-280549-bsnz24jx	81	41	and	and	CC
cord-280549-bsnz24jx	81	42	E	E	NNP
cord-280549-bsnz24jx	81	43	(	(	-LRB-
cord-280549-bsnz24jx	81	44	Aleem	Aleem	NNP
cord-280549-bsnz24jx	81	45	et	et	NNP
cord-280549-bsnz24jx	81	46	al	al	NNP
cord-280549-bsnz24jx	81	47	.	.	NNP
cord-280549-bsnz24jx	81	48	,	,	,
cord-280549-bsnz24jx	81	49	2005	2005	CD
cord-280549-bsnz24jx	81	50	;	;	:
cord-280549-bsnz24jx	81	51	Petri	Petri	NNP
cord-280549-bsnz24jx	81	52	et	et	FW
cord-280549-bsnz24jx	81	53	al	al	NNP
cord-280549-bsnz24jx	81	54	.	.	NNP
cord-280549-bsnz24jx	81	55	,	,	,
cord-280549-bsnz24jx	81	56	2007	2007	CD
cord-280549-bsnz24jx	81	57	;	;	:
cord-280549-bsnz24jx	81	58	Santamaría	Santamaría	NNP
cord-280549-bsnz24jx	81	59	et	et	NNP
cord-280549-bsnz24jx	81	60	al	al	NNP
cord-280549-bsnz24jx	81	61	.	.	NNP
cord-280549-bsnz24jx	81	62	,	,	,
cord-280549-bsnz24jx	81	63	2007	2007	CD
cord-280549-bsnz24jx	81	64	)	)	-RRB-
cord-280549-bsnz24jx	81	65	.	.	.
cord-280549-bsnz24jx	82	1	Thus	thus	RB
cord-280549-bsnz24jx	82	2	,	,	,
cord-280549-bsnz24jx	82	3	a	a	DT
cord-280549-bsnz24jx	82	4	minimal	minimal	JJ
cord-280549-bsnz24jx	82	5	threshold	threshold	NN
cord-280549-bsnz24jx	82	6	model	model	NN
cord-280549-bsnz24jx	82	7	of	of	IN
cord-280549-bsnz24jx	82	8	cell	cell	NN
cord-280549-bsnz24jx	82	9	cycle	cycle	NN
cord-280549-bsnz24jx	82	10	control	control	NN
cord-280549-bsnz24jx	82	11	has	have	VBZ
cord-280549-bsnz24jx	82	12	emerged	emerge	VBN
cord-280549-bsnz24jx	82	13	,	,	,
cord-280549-bsnz24jx	82	14	which	which	WDT
cord-280549-bsnz24jx	82	15	suggests	suggest	VBZ
cord-280549-bsnz24jx	82	16	that	that	IN
cord-280549-bsnz24jx	82	17	pairing	pairing	NN
cord-280549-bsnz24jx	82	18	of	of	IN
cord-280549-bsnz24jx	82	19	cyclin	cyclin	NN
cord-280549-bsnz24jx	82	20	A	a	NN
cord-280549-bsnz24jx	82	21	to	to	IN
cord-280549-bsnz24jx	82	22	either	either	CC
cord-280549-bsnz24jx	82	23	CDK1	CDK1	NNP
cord-280549-bsnz24jx	82	24	or	or	CC
cord-280549-bsnz24jx	82	25	CDK2	CDK2	NNP
cord-280549-bsnz24jx	82	26	is	be	VBZ
cord-280549-bsnz24jx	82	27	sufficient	sufficient	JJ
cord-280549-bsnz24jx	82	28	to	to	TO
cord-280549-bsnz24jx	82	29	trigger	trigger	VB
cord-280549-bsnz24jx	82	30	G1	G1	NNP
cord-280549-bsnz24jx	82	31	/	/	SYM
cord-280549-bsnz24jx	82	32	S	S	NNP
cord-280549-bsnz24jx	82	33	transition	transition	NN
cord-280549-bsnz24jx	82	34	,	,	,
cord-280549-bsnz24jx	82	35	whereas	whereas	IN
cord-280549-bsnz24jx	82	36	cyclin	cyclin	NNP
cord-280549-bsnz24jx	82	37	B	B	NNP
cord-280549-bsnz24jx	82	38	-	-	HYPH
cord-280549-bsnz24jx	82	39	CDK1	CDK1	NNP
cord-280549-bsnz24jx	82	40	activity	activity	NN
cord-280549-bsnz24jx	82	41	seems	seem	VBZ
cord-280549-bsnz24jx	82	42	to	to	TO
cord-280549-bsnz24jx	82	43	be	be	VB
cord-280549-bsnz24jx	82	44	required	require	VBN
cord-280549-bsnz24jx	82	45	for	for	IN
cord-280549-bsnz24jx	82	46	mitosis	mitosis	NN
cord-280549-bsnz24jx	82	47	.	.	.
cord-280549-bsnz24jx	83	1	Viruses	virus	NNS
cord-280549-bsnz24jx	83	2	keep	keep	VBP
cord-280549-bsnz24jx	83	3	evolving	evolve	VBG
cord-280549-bsnz24jx	83	4	strategies	strategy	NNS
cord-280549-bsnz24jx	83	5	to	to	TO
cord-280549-bsnz24jx	83	6	subvert	subvert	VB
cord-280549-bsnz24jx	83	7	the	the	DT
cord-280549-bsnz24jx	83	8	cellular	cellular	JJ
cord-280549-bsnz24jx	83	9	environment	environment	NN
cord-280549-bsnz24jx	83	10	of	of	IN
cord-280549-bsnz24jx	83	11	the	the	DT
cord-280549-bsnz24jx	83	12	host	host	NN
cord-280549-bsnz24jx	83	13	for	for	IN
cord-280549-bsnz24jx	83	14	replication	replication	NN
cord-280549-bsnz24jx	83	15	and	and	CC
cord-280549-bsnz24jx	83	16	survival	survival	NN
cord-280549-bsnz24jx	83	17	.	.	.
cord-280549-bsnz24jx	84	1	For	for	IN
cord-280549-bsnz24jx	84	2	example	example	NN
cord-280549-bsnz24jx	84	3	,	,	,
cord-280549-bsnz24jx	84	4	some	some	DT
cord-280549-bsnz24jx	84	5	viral	viral	JJ
cord-280549-bsnz24jx	84	6	infections	infection	NNS
cord-280549-bsnz24jx	84	7	induce	induce	VBP
cord-280549-bsnz24jx	84	8	cell	cell	NN
cord-280549-bsnz24jx	84	9	cycle	cycle	NN
cord-280549-bsnz24jx	84	10	arrest	arrest	NN
cord-280549-bsnz24jx	84	11	in	in	IN
cord-280549-bsnz24jx	84	12	lymphocytes	lymphocyte	NNS
cord-280549-bsnz24jx	84	13	to	to	TO
cord-280549-bsnz24jx	84	14	inhibit	inhibit	VB
cord-280549-bsnz24jx	84	15	the	the	DT
cord-280549-bsnz24jx	84	16	clonal	clonal	JJ
cord-280549-bsnz24jx	84	17	expansion	expansion	NN
cord-280549-bsnz24jx	84	18	of	of	IN
cord-280549-bsnz24jx	84	19	anti	anti	JJ
cord-280549-bsnz24jx	84	20	-	-	JJ
cord-280549-bsnz24jx	84	21	viral	viral	JJ
cord-280549-bsnz24jx	84	22	T	t	NN
cord-280549-bsnz24jx	84	23	or	or	CC
cord-280549-bsnz24jx	84	24	B	b	NN
cord-280549-bsnz24jx	84	25	lymphocytes	lymphocyte	NNS
cord-280549-bsnz24jx	84	26	as	as	IN
cord-280549-bsnz24jx	84	27	a	a	DT
cord-280549-bsnz24jx	84	28	way	way	NN
cord-280549-bsnz24jx	84	29	of	of	IN
cord-280549-bsnz24jx	84	30	immune	immune	JJ
cord-280549-bsnz24jx	84	31	evasion	evasion	NN
cord-280549-bsnz24jx	84	32	,	,	,
cord-280549-bsnz24jx	84	33	whereas	whereas	IN
cord-280549-bsnz24jx	84	34	carcinogenic	carcinogenic	JJ
cord-280549-bsnz24jx	84	35	viruses	virus	NNS
cord-280549-bsnz24jx	84	36	are	be	VBP
cord-280549-bsnz24jx	84	37	known	know	VBN
cord-280549-bsnz24jx	84	38	to	to	TO
cord-280549-bsnz24jx	84	39	antagonize	antagonize	VB
cord-280549-bsnz24jx	84	40	cell	cell	NN
cord-280549-bsnz24jx	84	41	cycle	cycle	NN
cord-280549-bsnz24jx	84	42	checkpoints	checkpoint	NNS
cord-280549-bsnz24jx	84	43	for	for	IN
cord-280549-bsnz24jx	84	44	neoplastic	neoplastic	JJ
cord-280549-bsnz24jx	84	45	transformation	transformation	NN
cord-280549-bsnz24jx	84	46	of	of	IN
cord-280549-bsnz24jx	84	47	infected	infected	JJ
cord-280549-bsnz24jx	84	48	cells	cell	NNS
cord-280549-bsnz24jx	84	49	.	.	.
cord-280549-bsnz24jx	85	1	Thus	thus	RB
cord-280549-bsnz24jx	85	2	,	,	,
cord-280549-bsnz24jx	85	3	elucidating	elucidate	VBG
cord-280549-bsnz24jx	85	4	mechanisms	mechanism	NNS
cord-280549-bsnz24jx	85	5	of	of	IN
cord-280549-bsnz24jx	85	6	virus	virus	NN
cord-280549-bsnz24jx	85	7	-	-	HYPH
cord-280549-bsnz24jx	85	8	induced	induce	VBN
cord-280549-bsnz24jx	85	9	deregulation	deregulation	NN
cord-280549-bsnz24jx	85	10	of	of	IN
cord-280549-bsnz24jx	85	11	host	host	NN
cord-280549-bsnz24jx	85	12	cell	cell	NN
cord-280549-bsnz24jx	85	13	cycle	cycle	NN
cord-280549-bsnz24jx	85	14	bears	bear	VBZ
cord-280549-bsnz24jx	85	15	both	both	CC
cord-280549-bsnz24jx	85	16	fundamental	fundamental	JJ
cord-280549-bsnz24jx	85	17	and	and	CC
cord-280549-bsnz24jx	85	18	translational	translational	JJ
cord-280549-bsnz24jx	85	19	relevance	relevance	NN
cord-280549-bsnz24jx	85	20	.	.	.
cord-280549-bsnz24jx	86	1	Normal	normal	JJ
cord-280549-bsnz24jx	86	2	cellular	cellular	JJ
cord-280549-bsnz24jx	86	3	function	function	NN
cord-280549-bsnz24jx	86	4	including	include	VBG
cord-280549-bsnz24jx	86	5	signal	signal	NN
cord-280549-bsnz24jx	86	6	transduction	transduction	NN
cord-280549-bsnz24jx	86	7	and	and	CC
cord-280549-bsnz24jx	86	8	metabolic	metabolic	JJ
cord-280549-bsnz24jx	86	9	processes	process	NNS
cord-280549-bsnz24jx	86	10	is	be	VBZ
cord-280549-bsnz24jx	86	11	often	often	RB
cord-280549-bsnz24jx	86	12	mediated	mediate	VBN
cord-280549-bsnz24jx	86	13	through	through	IN
cord-280549-bsnz24jx	86	14	protein	protein	NN
cord-280549-bsnz24jx	86	15	-	-	HYPH
cord-280549-bsnz24jx	86	16	protein	protein	NN
cord-280549-bsnz24jx	86	17	interactions	interaction	NNS
cord-280549-bsnz24jx	86	18	,	,	,
cord-280549-bsnz24jx	86	19	and	and	CC
cord-280549-bsnz24jx	86	20	are	be	VBP
cord-280549-bsnz24jx	86	21	routinely	routinely	RB
cord-280549-bsnz24jx	86	22	targeted	target	VBN
cord-280549-bsnz24jx	86	23	by	by	IN
cord-280549-bsnz24jx	86	24	viruses	virus	NNS
cord-280549-bsnz24jx	86	25	.	.	.
cord-280549-bsnz24jx	87	1	The	the	DT
cord-280549-bsnz24jx	87	2	host	host	NN
cord-280549-bsnz24jx	87	3	cell	cell	NN
cord-280549-bsnz24jx	87	4	cycle	cycle	NN
cord-280549-bsnz24jx	87	5	is	be	VBZ
cord-280549-bsnz24jx	87	6	no	no	DT
cord-280549-bsnz24jx	87	7	exception	exception	NN
cord-280549-bsnz24jx	87	8	,	,	,
cord-280549-bsnz24jx	87	9	as	as	IN
cord-280549-bsnz24jx	87	10	illustrated	illustrate	VBN
cord-280549-bsnz24jx	87	11	below	below	IN
cord-280549-bsnz24jx	87	12	.	.	.
cord-280549-bsnz24jx	88	1	Cyclin	Cyclin	NNP
cord-280549-bsnz24jx	88	2	and	and	CC
cord-280549-bsnz24jx	88	3	CDK	CDK	NNP
cord-280549-bsnz24jx	88	4	are	be	VBP
cord-280549-bsnz24jx	88	5	components	component	NNS
cord-280549-bsnz24jx	88	6	that	that	WDT
cord-280549-bsnz24jx	88	7	drive	drive	VBP
cord-280549-bsnz24jx	88	8	the	the	DT
cord-280549-bsnz24jx	88	9	cell	cell	NN
cord-280549-bsnz24jx	88	10	cycle	cycle	NN
cord-280549-bsnz24jx	88	11	clock	clock	NN
cord-280549-bsnz24jx	88	12	by	by	IN
cord-280549-bsnz24jx	88	13	forming	form	VBG
cord-280549-bsnz24jx	88	14	an	an	DT
cord-280549-bsnz24jx	88	15	active	active	JJ
cord-280549-bsnz24jx	88	16	protein	protein	NN
cord-280549-bsnz24jx	88	17	complex	complex	NN
cord-280549-bsnz24jx	88	18	that	that	WDT
cord-280549-bsnz24jx	88	19	could	could	MD
cord-280549-bsnz24jx	88	20	be	be	VB
cord-280549-bsnz24jx	88	21	directly	directly	RB
cord-280549-bsnz24jx	88	22	targeted	target	VBN
cord-280549-bsnz24jx	88	23	by	by	IN
cord-280549-bsnz24jx	88	24	viruses	virus	NNS
cord-280549-bsnz24jx	88	25	to	to	TO
cord-280549-bsnz24jx	88	26	modulate	modulate	VB
cord-280549-bsnz24jx	88	27	cell	cell	NN
cord-280549-bsnz24jx	88	28	cycle	cycle	NN
cord-280549-bsnz24jx	88	29	progression	progression	NN
cord-280549-bsnz24jx	88	30	.	.	.
cord-280549-bsnz24jx	89	1	Binding	bind	VBG
cord-280549-bsnz24jx	89	2	of	of	IN
cord-280549-bsnz24jx	89	3	the	the	DT
cord-280549-bsnz24jx	89	4	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	89	5	Tax	Tax	NNP
cord-280549-bsnz24jx	89	6	of	of	IN
cord-280549-bsnz24jx	89	7	HTLV-1	HTLV-1	NNP
cord-280549-bsnz24jx	89	8	to	to	TO
cord-280549-bsnz24jx	89	9	cyclin	cyclin	VB
cord-280549-bsnz24jx	89	10	D1	D1	NNP
cord-280549-bsnz24jx	89	11	/	/	SYM
cord-280549-bsnz24jx	89	12	D3	D3	NNP
cord-280549-bsnz24jx	89	13	was	be	VBD
cord-280549-bsnz24jx	89	14	observed	observe	VBN
cord-280549-bsnz24jx	89	15	in	in	IN
cord-280549-bsnz24jx	89	16	transfected	transfecte	VBN
cord-280549-bsnz24jx	89	17	cells	cell	NNS
cord-280549-bsnz24jx	89	18	by	by	IN
cord-280549-bsnz24jx	89	19	co	co	NN
cord-280549-bsnz24jx	89	20	-	-	NN
cord-280549-bsnz24jx	89	21	immunoprecipitation	immunoprecipitation	JJ
cord-280549-bsnz24jx	89	22	(	(	-LRB-
cord-280549-bsnz24jx	89	23	Neuveut	Neuveut	NNP
cord-280549-bsnz24jx	89	24	et	et	NNP
cord-280549-bsnz24jx	89	25	al	al	NNP
cord-280549-bsnz24jx	89	26	.	.	NNP
cord-280549-bsnz24jx	89	27	,	,	,
cord-280549-bsnz24jx	89	28	1998	1998	CD
cord-280549-bsnz24jx	89	29	)	)	-RRB-
cord-280549-bsnz24jx	89	30	.	.	.
cord-280549-bsnz24jx	90	1	This	this	DT
cord-280549-bsnz24jx	90	2	interaction	interaction	NN
cord-280549-bsnz24jx	90	3	is	be	VBZ
cord-280549-bsnz24jx	90	4	implicated	implicate	VBN
cord-280549-bsnz24jx	90	5	in	in	IN
cord-280549-bsnz24jx	90	6	the	the	DT
cord-280549-bsnz24jx	90	7	ability	ability	NN
cord-280549-bsnz24jx	90	8	of	of	IN
cord-280549-bsnz24jx	90	9	Tax	tax	NN
cord-280549-bsnz24jx	90	10	to	to	TO
cord-280549-bsnz24jx	90	11	promote	promote	VB
cord-280549-bsnz24jx	90	12	progression	progression	NN
cord-280549-bsnz24jx	90	13	through	through	IN
cord-280549-bsnz24jx	90	14	S	s	NN
cord-280549-bsnz24jx	90	15	phase	phase	NN
cord-280549-bsnz24jx	90	16	,	,	,
cord-280549-bsnz24jx	90	17	as	as	IN
cord-280549-bsnz24jx	90	18	cells	cell	NNS
cord-280549-bsnz24jx	90	19	expressing	express	VBG
cord-280549-bsnz24jx	90	20	a	a	DT
cord-280549-bsnz24jx	90	21	cyclin	cyclin	NN
cord-280549-bsnz24jx	90	22	D3deficient	d3deficient	NN
cord-280549-bsnz24jx	90	23	in	in	IN
cord-280549-bsnz24jx	90	24	Tax	tax	NN
cord-280549-bsnz24jx	90	25	-	-	HYPH
cord-280549-bsnz24jx	90	26	binding	bind	VBG
cord-280549-bsnz24jx	90	27	exhibit	exhibit	NN
cord-280549-bsnz24jx	90	28	much	much	RB
cord-280549-bsnz24jx	90	29	lesser	less	JJR
cord-280549-bsnz24jx	90	30	thymidine	thymidine	NN
cord-280549-bsnz24jx	90	31	incorporation	incorporation	NN
cord-280549-bsnz24jx	90	32	(	(	-LRB-
cord-280549-bsnz24jx	90	33	Neuveut	Neuveut	NNP
cord-280549-bsnz24jx	90	34	et	et	NNP
cord-280549-bsnz24jx	90	35	al	al	NNP
cord-280549-bsnz24jx	90	36	.	.	NNP
cord-280549-bsnz24jx	90	37	,	,	,
cord-280549-bsnz24jx	90	38	1998	1998	CD
cord-280549-bsnz24jx	90	39	)	)	-RRB-
cord-280549-bsnz24jx	90	40	.	.	.
cord-280549-bsnz24jx	91	1	Interestingly	interestingly	RB
cord-280549-bsnz24jx	91	2	,	,	,
cord-280549-bsnz24jx	91	3	Haller	Haller	NNP
cord-280549-bsnz24jx	91	4	et	et	NNP
cord-280549-bsnz24jx	91	5	al	al	NNP
cord-280549-bsnz24jx	91	6	.	.	.
cord-280549-bsnz24jx	92	1	later	later	RB
cord-280549-bsnz24jx	92	2	demonstrated	demonstrate	VBD
cord-280549-bsnz24jx	92	3	that	that	IN
cord-280549-bsnz24jx	92	4	Tax	Tax	NNP
cord-280549-bsnz24jx	92	5	could	could	MD
cord-280549-bsnz24jx	92	6	also	also	RB
cord-280549-bsnz24jx	92	7	stimulate	stimulate	VB
cord-280549-bsnz24jx	92	8	CDK4	CDK4	NNP
cord-280549-bsnz24jx	92	9	activity	activity	NN
cord-280549-bsnz24jx	92	10	through	through	IN
cord-280549-bsnz24jx	92	11	direct	direct	JJ
cord-280549-bsnz24jx	92	12	physical	physical	JJ
cord-280549-bsnz24jx	92	13	interaction	interaction	NN
cord-280549-bsnz24jx	92	14	via	via	IN
cord-280549-bsnz24jx	92	15	its	-PRON-	PRP$
cord-280549-bsnz24jx	92	16	N	n	CD
cord-280549-bsnz24jx	92	17	-	-	HYPH
cord-280549-bsnz24jx	92	18	terminal	terminal	NN
cord-280549-bsnz24jx	92	19	region	region	NN
cord-280549-bsnz24jx	92	20	(	(	-LRB-
cord-280549-bsnz24jx	92	21	Haller	Haller	NNP
cord-280549-bsnz24jx	92	22	et	et	NNP
cord-280549-bsnz24jx	92	23	al	al	NNP
cord-280549-bsnz24jx	92	24	.	.	NNP
cord-280549-bsnz24jx	92	25	,	,	,
cord-280549-bsnz24jx	92	26	2002	2002	CD
cord-280549-bsnz24jx	92	27	)	)	-RRB-
cord-280549-bsnz24jx	92	28	.	.	.
cord-280549-bsnz24jx	93	1	A	a	DT
cord-280549-bsnz24jx	93	2	binding	binding	NN
cord-280549-bsnz24jx	93	3	-	-	HYPH
cord-280549-bsnz24jx	93	4	deficient	deficient	JJ
cord-280549-bsnz24jx	93	5	Tax	tax	NN
cord-280549-bsnz24jx	93	6	variant	variant	NN
cord-280549-bsnz24jx	93	7	failed	fail	VBD
cord-280549-bsnz24jx	93	8	to	to	TO
cord-280549-bsnz24jx	93	9	stimulate	stimulate	VB
cord-280549-bsnz24jx	93	10	CDK4-cyclin	CDK4-cyclin	NNP
cord-280549-bsnz24jx	93	11	D	D	NNP
cord-280549-bsnz24jx	93	12	complex	complex	JJ
cord-280549-bsnz24jx	93	13	formation	formation	NN
cord-280549-bsnz24jx	93	14	and	and	CC
cord-280549-bsnz24jx	93	15	lost	lose	VBD
cord-280549-bsnz24jx	93	16	its	-PRON-	PRP$
cord-280549-bsnz24jx	93	17	ability	ability	NN
cord-280549-bsnz24jx	93	18	to	to	TO
cord-280549-bsnz24jx	93	19	antagonize	antagonize	VB
cord-280549-bsnz24jx	93	20	the	the	DT
cord-280549-bsnz24jx	93	21	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	93	22	effect	effect	NN
cord-280549-bsnz24jx	93	23	of	of	IN
cord-280549-bsnz24jx	93	24	cyclin	cyclin	NN
cord-280549-bsnz24jx	93	25	-	-	HYPH
cord-280549-bsnz24jx	93	26	dependent	dependent	JJ
cord-280549-bsnz24jx	93	27	kinase	kinase	NN
cord-280549-bsnz24jx	93	28	inhibitor	inhibitor	NN
cord-280549-bsnz24jx	93	29	(	(	-LRB-
cord-280549-bsnz24jx	93	30	CKI	CKI	NNP
cord-280549-bsnz24jx	93	31	)	)	-RRB-
cord-280549-bsnz24jx	93	32	p21	p21	NN
cord-280549-bsnz24jx	93	33	WAF1	WAF1	NNP
cord-280549-bsnz24jx	93	34	/	/	SYM
cord-280549-bsnz24jx	93	35	CIP1	CIP1	NNP
cord-280549-bsnz24jx	93	36	,	,	,
cord-280549-bsnz24jx	93	37	underlying	underlie	VBG
cord-280549-bsnz24jx	93	38	the	the	DT
cord-280549-bsnz24jx	93	39	importance	importance	NN
cord-280549-bsnz24jx	93	40	of	of	IN
cord-280549-bsnz24jx	93	41	protein	protein	NN
cord-280549-bsnz24jx	93	42	interaction	interaction	NN
cord-280549-bsnz24jx	93	43	in	in	IN
cord-280549-bsnz24jx	93	44	Tax	tax	NN
cord-280549-bsnz24jx	93	45	-	-	HYPH
cord-280549-bsnz24jx	93	46	mediated	mediate	VBN
cord-280549-bsnz24jx	93	47	cell	cell	NN
cord-280549-bsnz24jx	93	48	cycle	cycle	NN
cord-280549-bsnz24jx	93	49	regulation	regulation	NN
cord-280549-bsnz24jx	94	1	(	(	-LRB-
cord-280549-bsnz24jx	94	2	Haller	Haller	NNP
cord-280549-bsnz24jx	94	3	et	et	NNP
cord-280549-bsnz24jx	94	4	al	al	NNP
cord-280549-bsnz24jx	94	5	.	.	NNP
cord-280549-bsnz24jx	94	6	,	,	,
cord-280549-bsnz24jx	94	7	2002	2002	CD
cord-280549-bsnz24jx	94	8	)	)	-RRB-
cord-280549-bsnz24jx	94	9	.	.	.
cord-280549-bsnz24jx	95	1	Chronic	chronic	JJ
cord-280549-bsnz24jx	95	2	hepatitis	hepatitis	NN
cord-280549-bsnz24jx	95	3	B	b	NN
cord-280549-bsnz24jx	95	4	virus	virus	NN
cord-280549-bsnz24jx	95	5	(	(	-LRB-
cord-280549-bsnz24jx	95	6	HBV	HBV	NNP
cord-280549-bsnz24jx	95	7	)	)	-RRB-
cord-280549-bsnz24jx	95	8	infection	infection	NN
cord-280549-bsnz24jx	95	9	is	be	VBZ
cord-280549-bsnz24jx	95	10	associated	associate	VBN
cord-280549-bsnz24jx	95	11	with	with	IN
cord-280549-bsnz24jx	95	12	the	the	DT
cord-280549-bsnz24jx	95	13	development	development	NN
cord-280549-bsnz24jx	95	14	of	of	IN
cord-280549-bsnz24jx	95	15	hepatocellular	hepatocellular	JJ
cord-280549-bsnz24jx	95	16	carcinoma	carcinoma	NN
cord-280549-bsnz24jx	95	17	,	,	,
cord-280549-bsnz24jx	95	18	and	and	CC
cord-280549-bsnz24jx	95	19	the	the	DT
cord-280549-bsnz24jx	95	20	X	x	NN
cord-280549-bsnz24jx	95	21	protein	protein	NN
cord-280549-bsnz24jx	95	22	of	of	IN
cord-280549-bsnz24jx	95	23	HBV	HBV	NNP
cord-280549-bsnz24jx	95	24	(	(	-LRB-
cord-280549-bsnz24jx	95	25	HBx	HBx	NNP
cord-280549-bsnz24jx	95	26	)	)	-RRB-
cord-280549-bsnz24jx	95	27	was	be	VBD
cord-280549-bsnz24jx	95	28	found	find	VBN
cord-280549-bsnz24jx	95	29	to	to	TO
cord-280549-bsnz24jx	95	30	stimulate	stimulate	VB
cord-280549-bsnz24jx	95	31	S	S	NNP
cord-280549-bsnz24jx	95	32	phase	phase	NN
cord-280549-bsnz24jx	95	33	entry	entry	NN
cord-280549-bsnz24jx	95	34	of	of	IN
cord-280549-bsnz24jx	95	35	growth	growth	NN
cord-280549-bsnz24jx	95	36	-	-	HYPH
cord-280549-bsnz24jx	95	37	arrested	arrest	VBN
cord-280549-bsnz24jx	95	38	cells	cell	NNS
cord-280549-bsnz24jx	95	39	(	(	-LRB-
cord-280549-bsnz24jx	95	40	Benn	Benn	NNP
cord-280549-bsnz24jx	95	41	and	and	CC
cord-280549-bsnz24jx	95	42	Schneider	Schneider	NNP
cord-280549-bsnz24jx	95	43	,	,	,
cord-280549-bsnz24jx	95	44	1995	1995	CD
cord-280549-bsnz24jx	95	45	)	)	-RRB-
cord-280549-bsnz24jx	95	46	.	.	.
cord-280549-bsnz24jx	96	1	Coimmunoprecipitation	Coimmunoprecipitation	NNP
cord-280549-bsnz24jx	96	2	in	in	IN
cord-280549-bsnz24jx	96	3	HBx	hbx	NN
cord-280549-bsnz24jx	96	4	-	-	HYPH
cord-280549-bsnz24jx	96	5	expressing	express	VBG
cord-280549-bsnz24jx	96	6	cells	cell	NNS
cord-280549-bsnz24jx	96	7	demonstrated	demonstrate	VBD
cord-280549-bsnz24jx	96	8	that	that	IN
cord-280549-bsnz24jx	96	9	this	this	DT
cord-280549-bsnz24jx	96	10	viral	viral	JJ
cord-280549-bsnz24jx	96	11	protein	protein	NN
cord-280549-bsnz24jx	96	12	binds	bind	VBZ
cord-280549-bsnz24jx	96	13	to	to	IN
cord-280549-bsnz24jx	96	14	cyclin	cyclin	NN
cord-280549-bsnz24jx	96	15	E	E	NNP
cord-280549-bsnz24jx	96	16	/	/	CC
cord-280549-bsnz24jx	96	17	A	A	NNP
cord-280549-bsnz24jx	96	18	-	-	HYPH
cord-280549-bsnz24jx	96	19	CDK2	CDK2	NNP
cord-280549-bsnz24jx	96	20	complexes	complex	NNS
cord-280549-bsnz24jx	96	21	.	.	.
cord-280549-bsnz24jx	97	1	Mutant	mutant	JJ
cord-280549-bsnz24jx	97	2	HBx	HBx	NNS
cord-280549-bsnz24jx	97	3	,	,	,
cord-280549-bsnz24jx	97	4	which	which	WDT
cord-280549-bsnz24jx	97	5	displayed	display	VBD
cord-280549-bsnz24jx	97	6	disrupted	disrupted	JJ
cord-280549-bsnz24jx	97	7	interaction	interaction	NN
cord-280549-bsnz24jx	97	8	with	with	IN
cord-280549-bsnz24jx	97	9	cyclin	cyclin	JJ
cord-280549-bsnz24jx	97	10	-	-	HYPH
cord-280549-bsnz24jx	97	11	CDK	CDK	NNP
cord-280549-bsnz24jx	97	12	complexes	complex	NNS
cord-280549-bsnz24jx	97	13	,	,	,
cord-280549-bsnz24jx	97	14	failed	fail	VBD
cord-280549-bsnz24jx	97	15	to	to	TO
cord-280549-bsnz24jx	97	16	increase	increase	VB
cord-280549-bsnz24jx	97	17	CDK2	CDK2	NNP
cord-280549-bsnz24jx	97	18	activity	activity	NN
cord-280549-bsnz24jx	97	19	and	and	CC
cord-280549-bsnz24jx	97	20	,	,	,
cord-280549-bsnz24jx	97	21	similarly	similarly	RB
cord-280549-bsnz24jx	97	22	to	to	IN
cord-280549-bsnz24jx	97	23	Tax	Tax	NNP
cord-280549-bsnz24jx	97	24	,	,	,
cord-280549-bsnz24jx	97	25	lost	lose	VBD
cord-280549-bsnz24jx	97	26	its	-PRON-	PRP$
cord-280549-bsnz24jx	97	27	effectiveness	effectiveness	NN
cord-280549-bsnz24jx	97	28	in	in	IN
cord-280549-bsnz24jx	97	29	counteracting	counteract	VBG
cord-280549-bsnz24jx	97	30	the	the	DT
cord-280549-bsnz24jx	97	31	action	action	NN
cord-280549-bsnz24jx	97	32	ofp27	ofp27	CD
cord-280549-bsnz24jx	97	33	KIP1	KIP1	NNP
cord-280549-bsnz24jx	97	34	(	(	-LRB-
cord-280549-bsnz24jx	97	35	Mukherji	Mukherji	NNP
cord-280549-bsnz24jx	97	36	et	et	NNP
cord-280549-bsnz24jx	97	37	al	al	NNP
cord-280549-bsnz24jx	97	38	.	.	NNP
cord-280549-bsnz24jx	97	39	,	,	,
cord-280549-bsnz24jx	97	40	2007	2007	CD
cord-280549-bsnz24jx	97	41	)	)	-RRB-
cord-280549-bsnz24jx	97	42	.	.	.
cord-280549-bsnz24jx	98	1	The	the	DT
cord-280549-bsnz24jx	98	2	examples	example	NNS
cord-280549-bsnz24jx	98	3	of	of	IN
cord-280549-bsnz24jx	98	4	Tax	Tax	NNP
cord-280549-bsnz24jx	98	5	and	and	CC
cord-280549-bsnz24jx	98	6	Hobs	Hobs	NNPS
cord-280549-bsnz24jx	98	7	illustrate	illustrate	VBP
cord-280549-bsnz24jx	98	8	how	how	WRB
cord-280549-bsnz24jx	98	9	binding	bind	VBG
cord-280549-bsnz24jx	98	10	of	of	IN
cord-280549-bsnz24jx	98	11	viral	viral	JJ
cord-280549-bsnz24jx	98	12	protein	protein	NN
cord-280549-bsnz24jx	98	13	to	to	IN
cord-280549-bsnz24jx	98	14	cyclin	cyclin	NN
cord-280549-bsnz24jx	98	15	or	or	CC
cord-280549-bsnz24jx	98	16	CDK	CDK	NNP
cord-280549-bsnz24jx	98	17	promotes	promote	VBZ
cord-280549-bsnz24jx	98	18	cell	cell	NN
cord-280549-bsnz24jx	98	19	cycle	cycle	NN
cord-280549-bsnz24jx	98	20	progression	progression	NN
cord-280549-bsnz24jx	98	21	either	either	CC
cord-280549-bsnz24jx	98	22	by	by	IN
cord-280549-bsnz24jx	98	23	enhancing	enhance	VBG
cord-280549-bsnz24jx	98	24	kinase	kinase	NN
cord-280549-bsnz24jx	98	25	activity	activity	NN
cord-280549-bsnz24jx	98	26	and/or	and/or	CC
cord-280549-bsnz24jx	98	27	weakening	weaken	VBG
cord-280549-bsnz24jx	98	28	the	the	DT
cord-280549-bsnz24jx	98	29	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	98	30	effect	effect	NN
cord-280549-bsnz24jx	98	31	of	of	IN
cord-280549-bsnz24jx	98	32	CKI	CKI	NNP
cord-280549-bsnz24jx	98	33	.	.	.
cord-280549-bsnz24jx	99	1	The	the	DT
cord-280549-bsnz24jx	99	2	interaction	interaction	NN
cord-280549-bsnz24jx	99	3	of	of	IN
cord-280549-bsnz24jx	99	4	viral	viral	JJ
cord-280549-bsnz24jx	99	5	protein	protein	NN
cord-280549-bsnz24jx	99	6	with	with	IN
cord-280549-bsnz24jx	99	7	cyclin	cyclin	NN
cord-280549-bsnz24jx	99	8	or	or	CC
cord-280549-bsnz24jx	99	9	CDK	CDK	NNP
cord-280549-bsnz24jx	99	10	could	could	MD
cord-280549-bsnz24jx	99	11	also	also	RB
cord-280549-bsnz24jx	99	12	results	result	VBZ
cord-280549-bsnz24jx	99	13	in	in	IN
cord-280549-bsnz24jx	99	14	hampered	hamper	VBN
cord-280549-bsnz24jx	99	15	cell	cell	NN
cord-280549-bsnz24jx	99	16	division	division	NN
cord-280549-bsnz24jx	99	17	.	.	.
cord-280549-bsnz24jx	100	1	A	a	DT
cord-280549-bsnz24jx	100	2	direct	direct	JJ
cord-280549-bsnz24jx	100	3	binding	binding	NN
cord-280549-bsnz24jx	100	4	of	of	IN
cord-280549-bsnz24jx	100	5	the	the	DT
cord-280549-bsnz24jx	100	6	K	K	NNP
cord-280549-bsnz24jx	100	7	-	-	HYPH
cord-280549-bsnz24jx	100	8	bZIP	bzip	JJ
cord-280549-bsnz24jx	100	9	protein	protein	NN
cord-280549-bsnz24jx	100	10	of	of	IN
cord-280549-bsnz24jx	100	11	KSHV	KSHV	NNP
cord-280549-bsnz24jx	100	12	to	to	IN
cord-280549-bsnz24jx	100	13	CDK2	CDK2	NNP
cord-280549-bsnz24jx	100	14	,	,	,
cord-280549-bsnz24jx	100	15	cyclin	cyclin	NN
cord-280549-bsnz24jx	100	16	A	a	NN
cord-280549-bsnz24jx	100	17	,	,	,
cord-280549-bsnz24jx	100	18	or	or	CC
cord-280549-bsnz24jx	100	19	cyclin	cyclin	NN
cord-280549-bsnz24jx	100	20	E	e	NN
cord-280549-bsnz24jx	100	21	has	have	VBZ
cord-280549-bsnz24jx	100	22	been	be	VBN
cord-280549-bsnz24jx	100	23	demonstrated	demonstrate	VBN
cord-280549-bsnz24jx	100	24	using	use	VBG
cord-280549-bsnz24jx	100	25	purified	purify	VBN
cord-280549-bsnz24jx	100	26	proteins	protein	NNS
cord-280549-bsnz24jx	100	27	(	(	-LRB-
cord-280549-bsnz24jx	100	28	Izumiya	Izumiya	NNP
cord-280549-bsnz24jx	100	29	et	et	NNP
cord-280549-bsnz24jx	100	30	al	al	NNP
cord-280549-bsnz24jx	100	31	.	.	NNP
cord-280549-bsnz24jx	100	32	,	,	,
cord-280549-bsnz24jx	100	33	2003	2003	CD
cord-280549-bsnz24jx	100	34	)	)	-RRB-
cord-280549-bsnz24jx	100	35	.	.	.
cord-280549-bsnz24jx	101	1	These	these	DT
cord-280549-bsnz24jx	101	2	interactions	interaction	NNS
cord-280549-bsnz24jx	101	3	were	be	VBD
cord-280549-bsnz24jx	101	4	found	find	VBN
cord-280549-bsnz24jx	101	5	to	to	TO
cord-280549-bsnz24jx	101	6	impair	impair	VB
cord-280549-bsnz24jx	101	7	the	the	DT
cord-280549-bsnz24jx	101	8	kinase	kinase	NN
cord-280549-bsnz24jx	101	9	activity	activity	NN
cord-280549-bsnz24jx	101	10	of	of	IN
cord-280549-bsnz24jx	101	11	CDK2	CDK2	NNP
cord-280549-bsnz24jx	101	12	,	,	,
cord-280549-bsnz24jx	101	13	leading	lead	VBG
cord-280549-bsnz24jx	101	14	to	to	IN
cord-280549-bsnz24jx	101	15	extended	extend	VBN
cord-280549-bsnz24jx	101	16	G1	G1	NNP
cord-280549-bsnz24jx	101	17	duration	duration	NN
cord-280549-bsnz24jx	101	18	,	,	,
cord-280549-bsnz24jx	101	19	which	which	WDT
cord-280549-bsnz24jx	101	20	is	be	VBZ
cord-280549-bsnz24jx	101	21	accompanied	accompany	VBN
cord-280549-bsnz24jx	101	22	by	by	IN
cord-280549-bsnz24jx	101	23	increased	increase	VBN
cord-280549-bsnz24jx	101	24	production	production	NN
cord-280549-bsnz24jx	101	25	of	of	IN
cord-280549-bsnz24jx	101	26	the	the	DT
cord-280549-bsnz24jx	101	27	negative	negative	JJ
cord-280549-bsnz24jx	101	28	regulators	regulator	NNS
cord-280549-bsnz24jx	101	29	p21	p21	VBP
cord-280549-bsnz24jx	101	30	WAF1	WAF1	NNP
cord-280549-bsnz24jx	101	31	/	/	SYM
cord-280549-bsnz24jx	101	32	CIP1	CIP1	NNP
cord-280549-bsnz24jx	101	33	and	and	CC
cord-280549-bsnz24jx	101	34	p27	p27	NN
cord-280549-bsnz24jx	101	35	KIP1	KIP1	NNP
cord-280549-bsnz24jx	102	1	(	(	-LRB-
cord-280549-bsnz24jx	102	2	Izumiya	Izumiya	NNP
cord-280549-bsnz24jx	102	3	et	et	NNP
cord-280549-bsnz24jx	102	4	al	al	NNP
cord-280549-bsnz24jx	102	5	.	.	NNP
cord-280549-bsnz24jx	102	6	,	,	,
cord-280549-bsnz24jx	102	7	2003	2003	CD
cord-280549-bsnz24jx	102	8	)	)	-RRB-
cord-280549-bsnz24jx	102	9	.	.	.
cord-280549-bsnz24jx	103	1	Interestingly	interestingly	RB
cord-280549-bsnz24jx	103	2	p30	p30	NNP
cord-280549-bsnz24jx	103	3	,	,	,
cord-280549-bsnz24jx	103	4	another	another	DT
cord-280549-bsnz24jx	103	5	HTLV-1	HTLV-1	NNP
cord-280549-bsnz24jx	103	6	expressing	express	VBG
cord-280549-bsnz24jx	103	7	protein	protein	NN
cord-280549-bsnz24jx	103	8	,	,	,
cord-280549-bsnz24jx	103	9	blocks	block	VBZ
cord-280549-bsnz24jx	103	10	G1	G1	NNP
cord-280549-bsnz24jx	103	11	/	/	SYM
cord-280549-bsnz24jx	103	12	S	S	NNP
cord-280549-bsnz24jx	103	13	transition	transition	NN
cord-280549-bsnz24jx	103	14	in	in	IN
cord-280549-bsnz24jx	103	15	contrast	contrast	NN
cord-280549-bsnz24jx	103	16	to	to	IN
cord-280549-bsnz24jx	103	17	the	the	DT
cord-280549-bsnz24jx	103	18	neoplastic	neoplastic	JJ
cord-280549-bsnz24jx	103	19	effect	effect	NN
cord-280549-bsnz24jx	103	20	of	of	IN
cord-280549-bsnz24jx	103	21	Tax	tax	NN
cord-280549-bsnz24jx	103	22	.	.	.
cord-280549-bsnz24jx	104	1	CyclinE	cycline	RB
cord-280549-bsnz24jx	104	2	-	-	:
cord-280549-bsnz24jx	104	3	CDK2	cdk2	JJ
cord-280549-bsnz24jx	104	4	complex	complex	JJ
cord-280549-bsnz24jx	104	5	formation	formation	NN
cord-280549-bsnz24jx	104	6	is	be	VBZ
cord-280549-bsnz24jx	104	7	hindered	hinder	VBN
cord-280549-bsnz24jx	104	8	in	in	IN
cord-280549-bsnz24jx	104	9	p30	p30	NNP
cord-280549-bsnz24jx	104	10	expressing	express	VBG
cord-280549-bsnz24jx	104	11	cells	cell	NNS
cord-280549-bsnz24jx	104	12	due	due	JJ
cord-280549-bsnz24jx	104	13	to	to	IN
cord-280549-bsnz24jx	104	14	the	the	DT
cord-280549-bsnz24jx	104	15	interaction	interaction	NN
cord-280549-bsnz24jx	104	16	of	of	IN
cord-280549-bsnz24jx	104	17	p30	p30	NN
cord-280549-bsnz24jx	104	18	with	with	IN
cord-280549-bsnz24jx	104	19	both	both	DT
cord-280549-bsnz24jx	104	20	cyclin	cyclin	NN
cord-280549-bsnz24jx	104	21	E	e	NN
cord-280549-bsnz24jx	104	22	and	and	CC
cord-280549-bsnz24jx	104	23	CDK2	CDK2	NNP
cord-280549-bsnz24jx	104	24	,	,	,
cord-280549-bsnz24jx	104	25	leading	lead	VBG
cord-280549-bsnz24jx	104	26	to	to	IN
cord-280549-bsnz24jx	104	27	reduced	reduced	JJ
cord-280549-bsnz24jx	104	28	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	104	29	of	of	IN
cord-280549-bsnz24jx	104	30	the	the	DT
cord-280549-bsnz24jx	104	31	Rb	Rb	NNP
cord-280549-bsnz24jx	104	32	tumor	tumor	NN
cord-280549-bsnz24jx	104	33	suppressor	suppressor	NN
cord-280549-bsnz24jx	104	34	protein	protein	NN
cord-280549-bsnz24jx	104	35	(	(	-LRB-
cord-280549-bsnz24jx	104	36	Baydoun	Baydoun	NNP
cord-280549-bsnz24jx	104	37	et	et	NNP
cord-280549-bsnz24jx	104	38	al	al	NNP
cord-280549-bsnz24jx	104	39	.	.	NNP
cord-280549-bsnz24jx	104	40	,	,	,
cord-280549-bsnz24jx	104	41	2010	2010	CD
cord-280549-bsnz24jx	104	42	)	)	-RRB-
cord-280549-bsnz24jx	104	43	.	.	.
cord-280549-bsnz24jx	105	1	Infection	infection	NN
cord-280549-bsnz24jx	105	2	of	of	IN
cord-280549-bsnz24jx	105	3	influenza	influenza	NN
cord-280549-bsnz24jx	105	4	A	a	DT
cord-280549-bsnz24jx	105	5	virus	virus	NN
cord-280549-bsnz24jx	105	6	(	(	-LRB-
cord-280549-bsnz24jx	105	7	IAV	IAV	NNP
cord-280549-bsnz24jx	105	8	)	)	-RRB-
cord-280549-bsnz24jx	105	9	has	have	VBZ
cord-280549-bsnz24jx	105	10	been	be	VBN
cord-280549-bsnz24jx	105	11	reported	report	VBN
cord-280549-bsnz24jx	105	12	to	to	TO
cord-280549-bsnz24jx	105	13	induce	induce	VB
cord-280549-bsnz24jx	105	14	host	host	NN
cord-280549-bsnz24jx	105	15	cell	cell	NN
cord-280549-bsnz24jx	105	16	cycle	cycle	NN
cord-280549-bsnz24jx	105	17	G0	G0	NNP
cord-280549-bsnz24jx	105	18	/	/	SYM
cord-280549-bsnz24jx	105	19	G1	G1	NNP
cord-280549-bsnz24jx	105	20	phase	phase	NN
cord-280549-bsnz24jx	105	21	accumulation	accumulation	NN
cord-280549-bsnz24jx	105	22	(	(	-LRB-
cord-280549-bsnz24jx	105	23	He	-PRON-	PRP
cord-280549-bsnz24jx	105	24	et	et	FW
cord-280549-bsnz24jx	105	25	al	al	NNP
cord-280549-bsnz24jx	105	26	.	.	NNP
cord-280549-bsnz24jx	105	27	,	,	,
cord-280549-bsnz24jx	105	28	2010	2010	CD
cord-280549-bsnz24jx	105	29	;	;	:
cord-280549-bsnz24jx	105	30	Fan	Fan	NNP
cord-280549-bsnz24jx	105	31	et	et	NNP
cord-280549-bsnz24jx	105	32	al	al	NNP
cord-280549-bsnz24jx	105	33	.	.	NNP
cord-280549-bsnz24jx	105	34	,	,	,
cord-280549-bsnz24jx	105	35	2017	2017	CD
cord-280549-bsnz24jx	105	36	)	)	-RRB-
cord-280549-bsnz24jx	105	37	.	.	.
cord-280549-bsnz24jx	106	1	A	a	DT
cord-280549-bsnz24jx	106	2	yeast	yeast	NN
cord-280549-bsnz24jx	106	3	two	two	CD
cord-280549-bsnz24jx	106	4	-	-	HYPH
cord-280549-bsnz24jx	106	5	hybrid	hybrid	NN
cord-280549-bsnz24jx	106	6	screen	screen	NN
cord-280549-bsnz24jx	106	7	using	use	VBG
cord-280549-bsnz24jx	106	8	the	the	DT
cord-280549-bsnz24jx	106	9	cytoplasmic	cytoplasmic	JJ
cord-280549-bsnz24jx	106	10	tail	tail	NN
cord-280549-bsnz24jx	106	11	of	of	IN
cord-280549-bsnz24jx	106	12	matrix	matrix	NN
cord-280549-bsnz24jx	106	13	protein	protein	NN
cord-280549-bsnz24jx	106	14	2	2	CD
cord-280549-bsnz24jx	106	15	(	(	-LRB-
cord-280549-bsnz24jx	106	16	M2	M2	NNP
cord-280549-bsnz24jx	106	17	)	)	-RRB-
cord-280549-bsnz24jx	106	18	from	from	IN
cord-280549-bsnz24jx	106	19	the	the	DT
cord-280549-bsnz24jx	106	20	highly	highly	RB
cord-280549-bsnz24jx	106	21	pathogenic	pathogenic	JJ
cord-280549-bsnz24jx	106	22	H5N1	H5N1	NNP
cord-280549-bsnz24jx	106	23	strain	strain	NN
cord-280549-bsnz24jx	106	24	revealed	reveal	VBD
cord-280549-bsnz24jx	106	25	a	a	DT
cord-280549-bsnz24jx	106	26	high	high	JJ
cord-280549-bsnz24jx	106	27	-	-	HYPH
cord-280549-bsnz24jx	106	28	score	score	NN
cord-280549-bsnz24jx	106	29	interaction	interaction	NN
cord-280549-bsnz24jx	106	30	with	with	IN
cord-280549-bsnz24jx	106	31	cyclin	cyclin	NN
cord-280549-bsnz24jx	106	32	D3	D3	NNP
cord-280549-bsnz24jx	106	33	.	.	.
cord-280549-bsnz24jx	107	1	The	the	DT
cord-280549-bsnz24jx	107	2	M2	M2	NNP
cord-280549-bsnz24jx	107	3	ion	ion	NN
cord-280549-bsnz24jx	107	4	channel	channel	NN
cord-280549-bsnz24jx	107	5	protein	protein	NN
cord-280549-bsnz24jx	107	6	is	be	VBZ
cord-280549-bsnz24jx	107	7	a	a	DT
cord-280549-bsnz24jx	107	8	multifunctional	multifunctional	JJ
cord-280549-bsnz24jx	107	9	protein	protein	NN
cord-280549-bsnz24jx	107	10	with	with	IN
cord-280549-bsnz24jx	107	11	a	a	DT
cord-280549-bsnz24jx	107	12	highly	highly	RB
cord-280549-bsnz24jx	107	13	conserved	conserve	VBN
cord-280549-bsnz24jx	107	14	sequence	sequence	NN
cord-280549-bsnz24jx	107	15	among	among	IN
cord-280549-bsnz24jx	107	16	IAV	IAV	NNP
cord-280549-bsnz24jx	107	17	isolates	isolate	NNS
cord-280549-bsnz24jx	107	18	that	that	WDT
cord-280549-bsnz24jx	107	19	approaches	approach	VBZ
cord-280549-bsnz24jx	107	20	95	95	CD
cord-280549-bsnz24jx	107	21	%	%	NN
cord-280549-bsnz24jx	107	22	identity	identity	NN
cord-280549-bsnz24jx	107	23	in	in	IN
cord-280549-bsnz24jx	107	24	some	some	DT
cord-280549-bsnz24jx	107	25	regions	region	NNS
cord-280549-bsnz24jx	107	26	(	(	-LRB-
cord-280549-bsnz24jx	107	27	Le	Le	NNP
cord-280549-bsnz24jx	107	28	and	and	CC
cord-280549-bsnz24jx	107	29	Leluk	Leluk	NNP
cord-280549-bsnz24jx	107	30	,	,	,
cord-280549-bsnz24jx	107	31	2011	2011	CD
cord-280549-bsnz24jx	107	32	;	;	:
cord-280549-bsnz24jx	107	33	Pielak	Pielak	NNP
cord-280549-bsnz24jx	107	34	and	and	CC
cord-280549-bsnz24jx	107	35	Chou	Chou	NNP
cord-280549-bsnz24jx	107	36	,	,	,
cord-280549-bsnz24jx	107	37	2011	2011	CD
cord-280549-bsnz24jx	107	38	)	)	-RRB-
cord-280549-bsnz24jx	107	39	.	.	.
cord-280549-bsnz24jx	108	1	The	the	DT
cord-280549-bsnz24jx	108	2	physical	physical	JJ
cord-280549-bsnz24jx	108	3	interaction	interaction	NN
cord-280549-bsnz24jx	108	4	between	between	IN
cord-280549-bsnz24jx	108	5	M2	M2	NNP
cord-280549-bsnz24jx	108	6	and	and	CC
cord-280549-bsnz24jx	108	7	cyclin	cyclin	NN
cord-280549-bsnz24jx	108	8	D3	D3	NNP
cord-280549-bsnz24jx	108	9	was	be	VBD
cord-280549-bsnz24jx	108	10	confirmed	confirm	VBN
cord-280549-bsnz24jx	108	11	in	in	IN
cord-280549-bsnz24jx	108	12	virus	virus	NN
cord-280549-bsnz24jx	108	13	-	-	HYPH
cord-280549-bsnz24jx	108	14	infected	infect	VBN
cord-280549-bsnz24jx	108	15	cells	cell	NNS
cord-280549-bsnz24jx	108	16	,	,	,
cord-280549-bsnz24jx	108	17	was	be	VBD
cord-280549-bsnz24jx	108	18	accompanied	accompany	VBN
cord-280549-bsnz24jx	108	19	by	by	IN
cord-280549-bsnz24jx	108	20	cyclin	cyclin	NN
cord-280549-bsnz24jx	108	21	D3	D3	NNP
cord-280549-bsnz24jx	108	22	relocalization	relocalization	NN
cord-280549-bsnz24jx	108	23	and	and	CC
cord-280549-bsnz24jx	108	24	degradation	degradation	NN
cord-280549-bsnz24jx	108	25	,	,	,
cord-280549-bsnz24jx	108	26	and	and	CC
cord-280549-bsnz24jx	108	27	resulted	result	VBD
cord-280549-bsnz24jx	108	28	in	in	IN
cord-280549-bsnz24jx	108	29	host	host	NN
cord-280549-bsnz24jx	108	30	cell	cell	NN
cord-280549-bsnz24jx	108	31	cycle	cycle	NN
cord-280549-bsnz24jx	108	32	arrest	arrest	NN
cord-280549-bsnz24jx	108	33	in	in	IN
cord-280549-bsnz24jx	108	34	the	the	DT
cord-280549-bsnz24jx	108	35	G0	G0	NNP
cord-280549-bsnz24jx	108	36	/	/	SYM
cord-280549-bsnz24jx	108	37	G1	G1	NNP
cord-280549-bsnz24jx	108	38	phase	phase	NN
cord-280549-bsnz24jx	108	39	(	(	-LRB-
cord-280549-bsnz24jx	108	40	Fan	Fan	NNP
cord-280549-bsnz24jx	108	41	et	et	NNP
cord-280549-bsnz24jx	108	42	al	al	NNP
cord-280549-bsnz24jx	108	43	.	.	NNP
cord-280549-bsnz24jx	108	44	,	,	,
cord-280549-bsnz24jx	108	45	2017	2017	CD
cord-280549-bsnz24jx	108	46	)	)	-RRB-
cord-280549-bsnz24jx	108	47	.	.	.
cord-280549-bsnz24jx	109	1	The	the	DT
cord-280549-bsnz24jx	109	2	interaction	interaction	NN
cord-280549-bsnz24jx	109	3	of	of	IN
cord-280549-bsnz24jx	109	4	viral	viral	JJ
cord-280549-bsnz24jx	109	5	protein	protein	NN
cord-280549-bsnz24jx	109	6	with	with	IN
cord-280549-bsnz24jx	109	7	host	host	NN
cord-280549-bsnz24jx	109	8	cell	cell	NN
cord-280549-bsnz24jx	109	9	cycle	cycle	NN
cord-280549-bsnz24jx	109	10	machinery	machinery	NN
cord-280549-bsnz24jx	109	11	is	be	VBZ
cord-280549-bsnz24jx	109	12	not	not	RB
cord-280549-bsnz24jx	109	13	always	always	RB
cord-280549-bsnz24jx	109	14	favorable	favorable	JJ
cord-280549-bsnz24jx	109	15	for	for	IN
cord-280549-bsnz24jx	109	16	viral	viral	JJ
cord-280549-bsnz24jx	109	17	life	life	NN
cord-280549-bsnz24jx	109	18	cycle	cycle	NN
cord-280549-bsnz24jx	109	19	.	.	.
cord-280549-bsnz24jx	110	1	Using	use	VBG
cord-280549-bsnz24jx	110	2	a	a	DT
cord-280549-bsnz24jx	110	3	combination	combination	NN
cord-280549-bsnz24jx	110	4	of	of	IN
cord-280549-bsnz24jx	110	5	small	small	JJ
cord-280549-bsnz24jx	110	6	interfering	interfere	VBG
cord-280549-bsnz24jx	110	7	Werness	Werness	NNP
cord-280549-bsnz24jx	110	8	et	et	NNP
cord-280549-bsnz24jx	110	9	al	al	NNP
cord-280549-bsnz24jx	110	10	.	.	NNP
cord-280549-bsnz24jx	110	11	,	,	,
cord-280549-bsnz24jx	110	12	1990	1990	CD
cord-280549-bsnz24jx	110	13	;	;	:
cord-280549-bsnz24jx	110	14	Mietz	Mietz	NNP
cord-280549-bsnz24jx	110	15	et	et	NNP
cord-280549-bsnz24jx	110	16	al	al	NNP
cord-280549-bsnz24jx	110	17	.	.	NNP
cord-280549-bsnz24jx	110	18	,	,	,
cord-280549-bsnz24jx	110	19	1992	1992	CD
cord-280549-bsnz24jx	110	20	HPV	HPV	NNP
cord-280549-bsnz24jx	110	21	/	/	SYM
cord-280549-bsnz24jx	110	22	dsDNA	dsdna	RB
cord-280549-bsnz24jx	111	1	E7	E7	NNP
cord-280549-bsnz24jx	111	2	p27	p27	NN
cord-280549-bsnz24jx	111	3	KIP1	KIP1	NNP
cord-280549-bsnz24jx	111	4	Inhibition	Inhibition	NNP
cord-280549-bsnz24jx	111	5	of	of	IN
cord-280549-bsnz24jx	111	6	CKI	CKI	NNP
cord-280549-bsnz24jx	111	7	Zerfass-	Zerfass-	NNP
cord-280549-bsnz24jx	112	1	Thome	Thome	NNP
cord-280549-bsnz24jx	112	2	et	et	NNP
cord-280549-bsnz24jx	112	3	al	al	NNP
cord-280549-bsnz24jx	112	4	.	.	.
cord-280549-bsnz24jx	113	1	,	,	,
cord-280549-bsnz24jx	113	2	1996	1996	CD
cord-280549-bsnz24jx	113	3	;	;	:
cord-280549-bsnz24jx	113	4	Funk	Funk	NNP
cord-280549-bsnz24jx	113	5	et	et	NNP
cord-280549-bsnz24jx	113	6	al	al	NNP
cord-280549-bsnz24jx	113	7	.	.	NNP
cord-280549-bsnz24jx	113	8	,	,	,
cord-280549-bsnz24jx	113	9	1997	1997	CD
cord-280549-bsnz24jx	113	10	;	;	:
cord-280549-bsnz24jx	113	11	Jones	Jones	NNP
cord-280549-bsnz24jx	113	12	et	et	NNP
cord-280549-bsnz24jx	113	13	al	al	NNP
cord-280549-bsnz24jx	113	14	.	.	.
cord-280549-bsnz24jx	114	1	,	,	,
cord-280549-bsnz24jx	114	2	1997	1997	CD
cord-280549-bsnz24jx	114	3	HPV	HPV	NNP
cord-280549-bsnz24jx	114	4	/	/	,
cord-280549-bsnz24jx	114	5	dsDNA	dsdna	RB
cord-280549-bsnz24jx	115	1	E7	E7	NNP
cord-280549-bsnz24jx	115	2	Rb	Rb	NNP
cord-280549-bsnz24jx	115	3	Dissociation	Dissociation	NNP
cord-280549-bsnz24jx	115	4	of	of	IN
cord-280549-bsnz24jx	115	5	E2F	E2F	NNP
cord-280549-bsnz24jx	115	6	-	-	HYPH
cord-280549-bsnz24jx	115	7	Rb	Rb	NNP
cord-280549-bsnz24jx	115	8	/	/	SYM
cord-280549-bsnz24jx	115	9	p107	p107	NN
cord-280549-bsnz24jx	115	10	complexes	complex	NNS
cord-280549-bsnz24jx	115	11	Barbosa	Barbosa	NNP
cord-280549-bsnz24jx	115	12	et	et	NNP
cord-280549-bsnz24jx	115	13	al	al	NNP
cord-280549-bsnz24jx	115	14	.	.	NNP
cord-280549-bsnz24jx	115	15	,	,	,
cord-280549-bsnz24jx	115	16	1990	1990	CD
cord-280549-bsnz24jx	115	17	;	;	:
cord-280549-bsnz24jx	116	1	Huang	Huang	NNP
cord-280549-bsnz24jx	116	2	et	et	NNP
cord-280549-bsnz24jx	116	3	al	al	NNP
cord-280549-bsnz24jx	116	4	.	.	.
cord-280549-bsnz24jx	117	1	,	,	,
cord-280549-bsnz24jx	117	2	1993	1993	CD
cord-280549-bsnz24jx	117	3	;	;	:
cord-280549-bsnz24jx	117	4	Wu	Wu	NNP
cord-280549-bsnz24jx	117	5	et	et	NNP
cord-280549-bsnz24jx	117	6	al	al	NNP
cord-280549-bsnz24jx	117	7	.	.	NNP
cord-280549-bsnz24jx	117	8	,	,	,
cord-280549-bsnz24jx	118	1	1993	1993	CD
cord-280549-bsnz24jx	119	1	Avian	Avian	NNP
cord-280549-bsnz24jx	119	2	Bagchi	Bagchi	NNP
cord-280549-bsnz24jx	119	3	et	et	NNP
cord-280549-bsnz24jx	119	4	al	al	NNP
cord-280549-bsnz24jx	119	5	.	.	NNP
cord-280549-bsnz24jx	119	6	,	,	,
cord-280549-bsnz24jx	119	7	1990	1990	CD
cord-280549-bsnz24jx	119	8	;	;	:
cord-280549-bsnz24jx	119	9	Raychaudhuri	Raychaudhuri	NNP
cord-280549-bsnz24jx	119	10	et	et	NNP
cord-280549-bsnz24jx	119	11	al	al	NNP
cord-280549-bsnz24jx	119	12	.	.	NNP
cord-280549-bsnz24jx	119	13	,	,	,
cord-280549-bsnz24jx	119	14	1991	1991	CD
cord-280549-bsnz24jx	119	15	;	;	:
cord-280549-bsnz24jx	119	16	Ikeda	Ikeda	NNP
cord-280549-bsnz24jx	119	17	and	and	CC
cord-280549-bsnz24jx	119	18	Nevins	Nevins	NNP
cord-280549-bsnz24jx	119	19	,	,	,
cord-280549-bsnz24jx	119	20	1993	1993	CD
cord-280549-bsnz24jx	119	21	Adenovirus	Adenovirus	NNP
cord-280549-bsnz24jx	119	22	/	/	SYM
cord-280549-bsnz24jx	119	23	dsDNA	dsdna	RB
cord-280549-bsnz24jx	120	1	E1A	E1A	NNP
cord-280549-bsnz24jx	120	2	p300	p300	NNP
cord-280549-bsnz24jx	120	3	,	,	,
cord-280549-bsnz24jx	120	4	CBP	CBP	NNP
cord-280549-bsnz24jx	120	5	Inhibition	Inhibition	NNP
cord-280549-bsnz24jx	120	6	of	of	IN
cord-280549-bsnz24jx	120	7	the	the	DT
cord-280549-bsnz24jx	120	8	activation	activation	NN
cord-280549-bsnz24jx	120	9	of	of	IN
cord-280549-bsnz24jx	120	10	p21	p21	NN
cord-280549-bsnz24jx	120	11	WAF1	WAF1	NNP
cord-280549-bsnz24jx	120	12	/	/	SYM
cord-280549-bsnz24jx	120	13	CIP1	CIP1	NNP
cord-280549-bsnz24jx	120	14	,	,	,
cord-280549-bsnz24jx	120	15	blocking	block	VBG
cord-280549-bsnz24jx	120	16	p53-dependent	p53-dependent	NN
cord-280549-bsnz24jx	120	17	cell	cell	NN
cord-280549-bsnz24jx	120	18	cycle	cycle	NN
cord-280549-bsnz24jx	120	19	arrest	arrest	NN
cord-280549-bsnz24jx	120	20	Somasundaram	Somasundaram	NNP
cord-280549-bsnz24jx	120	21	and	and	CC
cord-280549-bsnz24jx	120	22	El	El	NNP
cord-280549-bsnz24jx	120	23	-	-	HYPH
cord-280549-bsnz24jx	120	24	Deiry	Deiry	NNP
cord-280549-bsnz24jx	120	25	,	,	,
cord-280549-bsnz24jx	120	26	1997	1997	CD
cord-280549-bsnz24jx	120	27	HCMV	HCMV	NNP
cord-280549-bsnz24jx	120	28	/	/	SYM
cord-280549-bsnz24jx	120	29	dsDNA	dsdna	RB
cord-280549-bsnz24jx	121	1	IE2	ie2	NN
cord-280549-bsnz24jx	121	2	-	-	HYPH
cord-280549-bsnz24jx	121	3	86	86	CD
cord-280549-bsnz24jx	122	1	CKI	CKI	NNP
cord-280549-bsnz24jx	122	2	Impaired	impaired	JJ
cord-280549-bsnz24jx	122	3	cell	cell	NN
cord-280549-bsnz24jx	122	4	cycle	cycle	NN
cord-280549-bsnz24jx	122	5	arrest	arrest	NN
cord-280549-bsnz24jx	122	6	in	in	IN
cord-280549-bsnz24jx	122	7	G2	G2	NNP
cord-280549-bsnz24jx	122	8	Sinclair	Sinclair	NNP
cord-280549-bsnz24jx	122	9	et	et	NNP
cord-280549-bsnz24jx	122	10	al	al	NNP
cord-280549-bsnz24jx	122	11	.	.	.
cord-280549-bsnz24jx	123	1	,	,	,
cord-280549-bsnz24jx	123	2	2000	2000	CD
cord-280549-bsnz24jx	123	3	HCMV	HCMV	NNP
cord-280549-bsnz24jx	123	4	/	/	SYM
cord-280549-bsnz24jx	123	5	dsDNA	dsdna	JJ
cord-280549-bsnz24jx	123	6	IE2	ie2	NN
cord-280549-bsnz24jx	123	7	-	-	HYPH
cord-280549-bsnz24jx	123	8	86	86	CD
cord-280549-bsnz24jx	123	9	,	,	,
cord-280549-bsnz24jx	124	1	mtrII	mtrII	NNP
cord-280549-bsnz24jx	125	1	p53	p53	NN
cord-280549-bsnz24jx	125	2	Repression	repression	NN
cord-280549-bsnz24jx	125	3	of	of	IN
cord-280549-bsnz24jx	125	4	p53	p53	NN
cord-280549-bsnz24jx	125	5	function	function	NN
cord-280549-bsnz24jx	126	1	Speir	Speir	NNP
cord-280549-bsnz24jx	126	2	et	et	NNP
cord-280549-bsnz24jx	126	3	al	al	NNP
cord-280549-bsnz24jx	126	4	.	.	.
cord-280549-bsnz24jx	127	1	,	,	,
cord-280549-bsnz24jx	127	2	1994	1994	CD
cord-280549-bsnz24jx	127	3	;	;	:
cord-280549-bsnz24jx	127	4	Thompson	Thompson	NNP
cord-280549-bsnz24jx	127	5	et	et	NNP
cord-280549-bsnz24jx	127	6	al	al	NNP
cord-280549-bsnz24jx	127	7	.	.	.
cord-280549-bsnz24jx	128	1	,	,	,
cord-280549-bsnz24jx	128	2	1994	1994	CD
cord-280549-bsnz24jx	128	3	;	;	:
cord-280549-bsnz24jx	128	4	Muralidhar	Muralidhar	NNP
cord-280549-bsnz24jx	128	5	et	et	NNP
cord-280549-bsnz24jx	128	6	al	al	NNP
cord-280549-bsnz24jx	128	7	.	.	.
cord-280549-bsnz24jx	129	1	,	,	,
cord-280549-bsnz24jx	129	2	1996	1996	CD
cord-280549-bsnz24jx	129	3	;	;	:
cord-280549-bsnz24jx	129	4	Tsai	Tsai	NNP
cord-280549-bsnz24jx	129	5	et	et	NNP
cord-280549-bsnz24jx	129	6	al	al	NNP
cord-280549-bsnz24jx	129	7	.	.	.
cord-280549-bsnz24jx	130	1	,	,	,
cord-280549-bsnz24jx	130	2	1996	1996	CD
cord-280549-bsnz24jx	130	3	SV40	SV40	NNP
cord-280549-bsnz24jx	130	4	/	/	SYM
cord-280549-bsnz24jx	130	5	dsDNA	dsdna	RB
cord-280549-bsnz24jx	131	1	Large	large	JJ
cord-280549-bsnz24jx	131	2	T	t	NN
cord-280549-bsnz24jx	131	3	antigen	antigen	NN
cord-280549-bsnz24jx	131	4	Rb	Rb	NNP
cord-280549-bsnz24jx	131	5	Dissociation	Dissociation	NNP
cord-280549-bsnz24jx	131	6	of	of	IN
cord-280549-bsnz24jx	131	7	E2F	e2f	NN
cord-280549-bsnz24jx	131	8	-	-	HYPH
cord-280549-bsnz24jx	131	9	Rb	Rb	NNP
cord-280549-bsnz24jx	131	10	/	/	SYM
cord-280549-bsnz24jx	131	11	p107	p107	NN
cord-280549-bsnz24jx	131	12	complexes	complex	NNS
cord-280549-bsnz24jx	132	1	Zalvide	Zalvide	NNP
cord-280549-bsnz24jx	132	2	et	et	NNP
cord-280549-bsnz24jx	132	3	al	al	NNP
cord-280549-bsnz24jx	132	4	.	.	NNP
cord-280549-bsnz24jx	132	5	,	,	,
cord-280549-bsnz24jx	132	6	1998	1998	CD
cord-280549-bsnz24jx	132	7	;	;	:
cord-280549-bsnz24jx	132	8	Sullivan	Sullivan	NNP
cord-280549-bsnz24jx	132	9	et	et	NNP
cord-280549-bsnz24jx	132	10	al	al	NNP
cord-280549-bsnz24jx	132	11	.	.	.
cord-280549-bsnz24jx	133	1	,	,	,
cord-280549-bsnz24jx	133	2	2000	2000	CD
cord-280549-bsnz24jx	134	1	SV40	SV40	NNP
cord-280549-bsnz24jx	134	2	/	/	SYM
cord-280549-bsnz24jx	134	3	dsDNA	dsdna	RB
cord-280549-bsnz24jx	135	1	Large	large	JJ
cord-280549-bsnz24jx	135	2	T	t	NN
cord-280549-bsnz24jx	135	3	antigen	antigen	NN
cord-280549-bsnz24jx	135	4	p53	p53	NN
cord-280549-bsnz24jx	135	5	Inhibition	inhibition	NN
cord-280549-bsnz24jx	135	6	of	of	IN
cord-280549-bsnz24jx	135	7	transactivation	transactivation	NN
cord-280549-bsnz24jx	136	1	Mietz	Mietz	NNP
cord-280549-bsnz24jx	136	2	et	et	NNP
cord-280549-bsnz24jx	136	3	al	al	NNP
cord-280549-bsnz24jx	136	4	.	.	NNP
cord-280549-bsnz24jx	136	5	,	,	,
cord-280549-bsnz24jx	137	1	1992	1992	CD
cord-280549-bsnz24jx	137	2	Epstein	Epstein	NNP
cord-280549-bsnz24jx	137	3	-	-	HYPH
cord-280549-bsnz24jx	137	4	Barr	Barr	NNP
cord-280549-bsnz24jx	137	5	/	/	SYM
cord-280549-bsnz24jx	137	6	dsDNA	dsdna	JJ
cord-280549-bsnz24jx	137	7	EBNA-5	EBNA-5	NNP
cord-280549-bsnz24jx	137	8	,	,	,
cord-280549-bsnz24jx	137	9	BRLF1	BRLF1	NNP
cord-280549-bsnz24jx	137	10	Rb	Rb	NNP
cord-280549-bsnz24jx	137	11	G0	G0	NNP
cord-280549-bsnz24jx	137	12	to	to	IN
cord-280549-bsnz24jx	137	13	G1	g1	NN
cord-280549-bsnz24jx	137	14	progression	progression	NN
cord-280549-bsnz24jx	138	1	Szekely	Szekely	NNP
cord-280549-bsnz24jx	138	2	et	et	NNP
cord-280549-bsnz24jx	138	3	al	al	NNP
cord-280549-bsnz24jx	138	4	.	.	.
cord-280549-bsnz24jx	139	1	,	,	,
cord-280549-bsnz24jx	139	2	1993	1993	CD
cord-280549-bsnz24jx	139	3	;	;	:
cord-280549-bsnz24jx	139	4	Zacny	Zacny	NNP
cord-280549-bsnz24jx	139	5	et	et	NNP
cord-280549-bsnz24jx	139	6	al	al	NNP
cord-280549-bsnz24jx	139	7	.	.	NNP
cord-280549-bsnz24jx	139	8	,	,	,
cord-280549-bsnz24jx	139	9	1998	1998	CD
cord-280549-bsnz24jx	139	10	Epstein	Epstein	NNP
cord-280549-bsnz24jx	139	11	-	-	HYPH
cord-280549-bsnz24jx	139	12	Barr	Barr	NNP
cord-280549-bsnz24jx	139	13	/	/	SYM
cord-280549-bsnz24jx	139	14	dsDNA	dsdna	RB
cord-280549-bsnz24jx	140	1	EBNA-3C	EBNA-3C	NNP
cord-280549-bsnz24jx	141	1	Chk2	Chk2	NNP
cord-280549-bsnz24jx	141	2	Reduced	reduce	VBN
cord-280549-bsnz24jx	142	1	Cdc25C	Cdc25C	NNP
cord-280549-bsnz24jx	143	1	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	143	2	,	,	,
cord-280549-bsnz24jx	143	3	abrogation	abrogation	NN
cord-280549-bsnz24jx	143	4	of	of	IN
cord-280549-bsnz24jx	143	5	the	the	DT
cord-280549-bsnz24jx	143	6	G2	G2	NNP
cord-280549-bsnz24jx	143	7	/	/	SYM
cord-280549-bsnz24jx	143	8	M	M	NNP
cord-280549-bsnz24jx	143	9	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	143	10	Choudhuri	Choudhuri	NNP
cord-280549-bsnz24jx	143	11	et	et	FW
cord-280549-bsnz24jx	143	12	al	al	NNP
cord-280549-bsnz24jx	143	13	.	.	NNP
cord-280549-bsnz24jx	143	14	,	,	,
cord-280549-bsnz24jx	143	15	2007	2007	CD
cord-280549-bsnz24jx	143	16	RNA	RNA	NNP
cord-280549-bsnz24jx	143	17	(	(	-LRB-
cord-280549-bsnz24jx	143	18	siRNA	siRNA	NNP
cord-280549-bsnz24jx	143	19	)	)	-RRB-
cord-280549-bsnz24jx	143	20	mediated	mediate	VBD
cord-280549-bsnz24jx	143	21	genetic	genetic	JJ
cord-280549-bsnz24jx	143	22	analysis	analysis	NN
cord-280549-bsnz24jx	144	1	it	-PRON-	PRP
cord-280549-bsnz24jx	144	2	has	have	VBZ
cord-280549-bsnz24jx	144	3	become	become	VBN
cord-280549-bsnz24jx	144	4	clear	clear	JJ
cord-280549-bsnz24jx	144	5	that	that	IN
cord-280549-bsnz24jx	144	6	cyclin	cyclin	NN
cord-280549-bsnz24jx	144	7	D3	D3	NNP
cord-280549-bsnz24jx	144	8	restricts	restrict	VBZ
cord-280549-bsnz24jx	144	9	IAV	IAV	NNP
cord-280549-bsnz24jx	144	10	production	production	NN
cord-280549-bsnz24jx	144	11	independent	independent	JJ
cord-280549-bsnz24jx	144	12	of	of	IN
cord-280549-bsnz24jx	144	13	its	-PRON-	PRP$
cord-280549-bsnz24jx	144	14	role	role	NN
cord-280549-bsnz24jx	144	15	in	in	IN
cord-280549-bsnz24jx	144	16	cell	cell	NN
cord-280549-bsnz24jx	144	17	cycle	cycle	NN
cord-280549-bsnz24jx	144	18	.	.	.
cord-280549-bsnz24jx	145	1	The	the	DT
cord-280549-bsnz24jx	145	2	biogenesis	biogenesis	NN
cord-280549-bsnz24jx	145	3	of	of	IN
cord-280549-bsnz24jx	145	4	viral	viral	JJ
cord-280549-bsnz24jx	145	5	particles	particle	NNS
cord-280549-bsnz24jx	145	6	involves	involve	VBZ
cord-280549-bsnz24jx	145	7	proper	proper	JJ
cord-280549-bsnz24jx	145	8	packaging	packaging	NN
cord-280549-bsnz24jx	145	9	and	and	CC
cord-280549-bsnz24jx	145	10	assembly	assembly	NN
cord-280549-bsnz24jx	145	11	of	of	IN
cord-280549-bsnz24jx	145	12	viral	viral	JJ
cord-280549-bsnz24jx	145	13	proteins	protein	NNS
cord-280549-bsnz24jx	145	14	and	and	CC
cord-280549-bsnz24jx	145	15	RNA	RNA	NNP
cord-280549-bsnz24jx	145	16	to	to	TO
cord-280549-bsnz24jx	145	17	form	form	VB
cord-280549-bsnz24jx	145	18	intact	intact	JJ
cord-280549-bsnz24jx	145	19	virions	virion	NNS
cord-280549-bsnz24jx	145	20	at	at	IN
cord-280549-bsnz24jx	145	21	discrete	discrete	JJ
cord-280549-bsnz24jx	145	22	budding	bud	VBG
cord-280549-bsnz24jx	145	23	sites	site	NNS
cord-280549-bsnz24jx	145	24	.	.	.
cord-280549-bsnz24jx	146	1	M2	M2	NNP
cord-280549-bsnz24jx	146	2	is	be	VBZ
cord-280549-bsnz24jx	146	3	a	a	DT
cord-280549-bsnz24jx	146	4	multifunctional	multifunctional	JJ
cord-280549-bsnz24jx	146	5	protein	protein	NN
cord-280549-bsnz24jx	146	6	:	:	:
cord-280549-bsnz24jx	146	7	its	-PRON-	PRP$
cord-280549-bsnz24jx	146	8	cytosolic	cytosolic	JJ
cord-280549-bsnz24jx	146	9	tail	tail	NN
cord-280549-bsnz24jx	146	10	interacts	interact	VBZ
cord-280549-bsnz24jx	146	11	with	with	IN
cord-280549-bsnz24jx	146	12	M1	M1	NNP
cord-280549-bsnz24jx	146	13	,	,	,
cord-280549-bsnz24jx	146	14	promoting	promote	VBG
cord-280549-bsnz24jx	146	15	the	the	DT
cord-280549-bsnz24jx	146	16	recruitment	recruitment	NN
cord-280549-bsnz24jx	146	17	of	of	IN
cord-280549-bsnz24jx	146	18	viral	viral	JJ
cord-280549-bsnz24jx	146	19	internal	internal	JJ
cord-280549-bsnz24jx	146	20	proteins	protein	NNS
cord-280549-bsnz24jx	146	21	and	and	CC
cord-280549-bsnz24jx	146	22	viral	viral	JJ
cord-280549-bsnz24jx	146	23	RNA	RNA	NNP
cord-280549-bsnz24jx	146	24	to	to	IN
cord-280549-bsnz24jx	146	25	the	the	DT
cord-280549-bsnz24jx	146	26	plasma	plasma	NN
cord-280549-bsnz24jx	146	27	membrane	membrane	NN
cord-280549-bsnz24jx	146	28	for	for	IN
cord-280549-bsnz24jx	146	29	efficient	efficient	JJ
cord-280549-bsnz24jx	146	30	virus	virus	NN
cord-280549-bsnz24jx	146	31	assembly	assembly	NN
cord-280549-bsnz24jx	146	32	.	.	.
cord-280549-bsnz24jx	147	1	The	the	DT
cord-280549-bsnz24jx	147	2	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	147	3	effect	effect	NN
cord-280549-bsnz24jx	147	4	of	of	IN
cord-280549-bsnz24jx	147	5	cyclin	cyclin	NN
cord-280549-bsnz24jx	147	6	D3	D3	NNP
cord-280549-bsnz24jx	147	7	on	on	IN
cord-280549-bsnz24jx	147	8	IAV	IAV	NNP
cord-280549-bsnz24jx	147	9	infection	infection	NN
cord-280549-bsnz24jx	147	10	is	be	VBZ
cord-280549-bsnz24jx	147	11	due	due	JJ
cord-280549-bsnz24jx	147	12	to	to	IN
cord-280549-bsnz24jx	147	13	its	-PRON-	PRP$
cord-280549-bsnz24jx	147	14	interaction	interaction	NN
cord-280549-bsnz24jx	147	15	with	with	IN
cord-280549-bsnz24jx	147	16	viral	viral	JJ
cord-280549-bsnz24jx	147	17	M2	M2	NNP
cord-280549-bsnz24jx	147	18	protein	protein	NN
cord-280549-bsnz24jx	147	19	,	,	,
cord-280549-bsnz24jx	147	20	as	as	IN
cord-280549-bsnz24jx	147	21	measured	measure	VBN
cord-280549-bsnz24jx	147	22	by	by	IN
cord-280549-bsnz24jx	147	23	competitive	competitive	JJ
cord-280549-bsnz24jx	147	24	co	co	JJ
cord-280549-bsnz24jx	147	25	-	-	JJ
cord-280549-bsnz24jx	147	26	immunoprecipitation	immunoprecipitation	JJ
cord-280549-bsnz24jx	147	27	assays	assay	NNS
cord-280549-bsnz24jx	147	28	,	,	,
cord-280549-bsnz24jx	147	29	indicating	indicate	VBG
cord-280549-bsnz24jx	147	30	that	that	IN
cord-280549-bsnz24jx	147	31	cyclin	cyclin	NN
cord-280549-bsnz24jx	147	32	D3-M2	d3-m2	JJ
cord-280549-bsnz24jx	147	33	interaction	interaction	NN
cord-280549-bsnz24jx	147	34	either	either	CC
cord-280549-bsnz24jx	147	35	masks	mask	VBZ
cord-280549-bsnz24jx	147	36	the	the	DT
cord-280549-bsnz24jx	147	37	domain	domain	NN
cord-280549-bsnz24jx	147	38	on	on	IN
cord-280549-bsnz24jx	147	39	M2	M2	NNP
cord-280549-bsnz24jx	147	40	mediating	mediate	VBG
cord-280549-bsnz24jx	147	41	binding	bind	VBG
cord-280549-bsnz24jx	147	42	to	to	IN
cord-280549-bsnz24jx	147	43	M1	M1	NNP
cord-280549-bsnz24jx	147	44	,	,	,
cord-280549-bsnz24jx	147	45	or	or	CC
cord-280549-bsnz24jx	147	46	has	have	VBZ
cord-280549-bsnz24jx	147	47	a	a	DT
cord-280549-bsnz24jx	147	48	higher	high	JJR
cord-280549-bsnz24jx	147	49	affinity	affinity	NN
cord-280549-bsnz24jx	147	50	than	than	IN
cord-280549-bsnz24jx	147	51	that	that	DT
cord-280549-bsnz24jx	147	52	between	between	IN
cord-280549-bsnz24jx	147	53	M1	M1	NNP
cord-280549-bsnz24jx	147	54	and	and	CC
cord-280549-bsnz24jx	147	55	M2	M2	NNP
cord-280549-bsnz24jx	147	56	.	.	.
cord-280549-bsnz24jx	148	1	Consequently	consequently	RB
cord-280549-bsnz24jx	148	2	,	,	,
cord-280549-bsnz24jx	148	3	limited	limited	JJ
cord-280549-bsnz24jx	148	4	M1-M2	M1-M2	NNP
cord-280549-bsnz24jx	148	5	binding	bind	VBG
cord-280549-bsnz24jx	148	6	during	during	IN
cord-280549-bsnz24jx	148	7	the	the	DT
cord-280549-bsnz24jx	148	8	budding	budding	JJ
cord-280549-bsnz24jx	148	9	process	process	NN
cord-280549-bsnz24jx	148	10	of	of	IN
cord-280549-bsnz24jx	148	11	IAV	IAV	NNP
cord-280549-bsnz24jx	148	12	infection	infection	NN
cord-280549-bsnz24jx	148	13	results	result	VBZ
cord-280549-bsnz24jx	148	14	in	in	IN
cord-280549-bsnz24jx	148	15	less	less	JJR
cord-280549-bsnz24jx	148	16	progeny	progeny	JJ
cord-280549-bsnz24jx	148	17	virions	virion	NNS
cord-280549-bsnz24jx	148	18	being	be	VBG
cord-280549-bsnz24jx	148	19	efficiently	efficiently	RB
cord-280549-bsnz24jx	148	20	packaged	package	VBN
cord-280549-bsnz24jx	148	21	and	and	CC
cord-280549-bsnz24jx	148	22	released	release	VBN
cord-280549-bsnz24jx	148	23	from	from	IN
cord-280549-bsnz24jx	148	24	host	host	NN
cord-280549-bsnz24jx	148	25	cells	cell	NNS
cord-280549-bsnz24jx	148	26	(	(	-LRB-
cord-280549-bsnz24jx	148	27	Fan	Fan	NNP
cord-280549-bsnz24jx	148	28	et	et	NNP
cord-280549-bsnz24jx	148	29	al	al	NNP
cord-280549-bsnz24jx	148	30	.	.	NNP
cord-280549-bsnz24jx	148	31	,	,	,
cord-280549-bsnz24jx	148	32	2017	2017	CD
cord-280549-bsnz24jx	148	33	)	)	-RRB-
cord-280549-bsnz24jx	148	34	.	.	.
cord-280549-bsnz24jx	149	1	These	these	DT
cord-280549-bsnz24jx	149	2	observations	observation	NNS
cord-280549-bsnz24jx	149	3	suggest	suggest	VBP
cord-280549-bsnz24jx	149	4	a	a	DT
cord-280549-bsnz24jx	149	5	novel	novel	JJ
cord-280549-bsnz24jx	149	6	function	function	NN
cord-280549-bsnz24jx	149	7	of	of	IN
cord-280549-bsnz24jx	149	8	cyclin	cyclin	NN
cord-280549-bsnz24jx	149	9	D3	D3	NNP
cord-280549-bsnz24jx	149	10	that	that	WDT
cord-280549-bsnz24jx	149	11	is	be	VBZ
cord-280549-bsnz24jx	149	12	beyond	beyond	IN
cord-280549-bsnz24jx	149	13	its	-PRON-	PRP$
cord-280549-bsnz24jx	149	14	classical	classical	JJ
cord-280549-bsnz24jx	149	15	function	function	NN
cord-280549-bsnz24jx	149	16	in	in	IN
cord-280549-bsnz24jx	149	17	cell	cell	NN
cord-280549-bsnz24jx	149	18	cycle	cycle	NN
cord-280549-bsnz24jx	149	19	regulation	regulation	NN
cord-280549-bsnz24jx	149	20	.	.	.
cord-280549-bsnz24jx	150	1	Hence	hence	RB
cord-280549-bsnz24jx	150	2	,	,	,
cord-280549-bsnz24jx	150	3	in	in	IN
cord-280549-bsnz24jx	150	4	this	this	DT
cord-280549-bsnz24jx	150	5	armed	armed	JJ
cord-280549-bsnz24jx	150	6	-	-	HYPH
cord-280549-bsnz24jx	150	7	race	race	NN
cord-280549-bsnz24jx	150	8	between	between	IN
cord-280549-bsnz24jx	150	9	cyclin	cyclin	NN
cord-280549-bsnz24jx	150	10	D3	D3	NNP
cord-280549-bsnz24jx	150	11	and	and	CC
cord-280549-bsnz24jx	150	12	M2	M2	NNP
cord-280549-bsnz24jx	150	13	during	during	IN
cord-280549-bsnz24jx	150	14	IAV	IAV	NNP
cord-280549-bsnz24jx	150	15	infection	infection	NN
cord-280549-bsnz24jx	150	16	,	,	,
cord-280549-bsnz24jx	150	17	the	the	DT
cord-280549-bsnz24jx	150	18	virus	virus	NN
cord-280549-bsnz24jx	150	19	evolved	evolve	VBD
cord-280549-bsnz24jx	150	20	strategies	strategy	NNS
cord-280549-bsnz24jx	150	21	to	to	TO
cord-280549-bsnz24jx	150	22	counteract	counteract	VB
cord-280549-bsnz24jx	150	23	the	the	DT
cord-280549-bsnz24jx	150	24	inhibition	inhibition	NN
cord-280549-bsnz24jx	150	25	imposed	impose	VBN
cord-280549-bsnz24jx	150	26	by	by	IN
cord-280549-bsnz24jx	150	27	cyclinD3	cyclind3	RB
cord-280549-bsnz24jx	150	28	,	,	,
cord-280549-bsnz24jx	150	29	resulting	result	VBG
cord-280549-bsnz24jx	150	30	in	in	IN
cord-280549-bsnz24jx	150	31	hampered	hamper	VBN
cord-280549-bsnz24jx	150	32	cell	cell	NN
cord-280549-bsnz24jx	150	33	cycle	cycle	NN
cord-280549-bsnz24jx	150	34	progression	progression	NN
cord-280549-bsnz24jx	150	35	.	.	.
cord-280549-bsnz24jx	151	1	Most	most	RBS
cord-280549-bsnz24jx	151	2	recently	recently	RB
cord-280549-bsnz24jx	151	3	,	,	,
cord-280549-bsnz24jx	151	4	Chiu	Chiu	NNP
cord-280549-bsnz24jx	151	5	et	et	NNP
cord-280549-bsnz24jx	151	6	al	al	NNP
cord-280549-bsnz24jx	151	7	.	.	NNP
cord-280549-bsnz24jx	151	8	identified	identify	VBD
cord-280549-bsnz24jx	151	9	a	a	DT
cord-280549-bsnz24jx	151	10	negatively	negatively	RB
cord-280549-bsnz24jx	151	11	charged	charge	VBN
cord-280549-bsnz24jx	151	12	pocket	pocket	NN
cord-280549-bsnz24jx	151	13	,	,	,
cord-280549-bsnz24jx	151	14	formed	form	VBN
cord-280549-bsnz24jx	151	15	by	by	IN
cord-280549-bsnz24jx	151	16	several	several	JJ
cord-280549-bsnz24jx	151	17	conserved	conserve	VBN
cord-280549-bsnz24jx	151	18	acidic	acidic	JJ
cord-280549-bsnz24jx	151	19	residues	residue	NNS
cord-280549-bsnz24jx	151	20	,	,	,
cord-280549-bsnz24jx	151	21	which	which	WDT
cord-280549-bsnz24jx	151	22	is	be	VBZ
cord-280549-bsnz24jx	151	23	required	require	VBN
cord-280549-bsnz24jx	151	24	for	for	IN
cord-280549-bsnz24jx	151	25	the	the	DT
cord-280549-bsnz24jx	151	26	binding	binding	NN
cord-280549-bsnz24jx	151	27	of	of	IN
cord-280549-bsnz24jx	151	28	p17	p17	NN
cord-280549-bsnz24jx	151	29	protein	protein	NN
cord-280549-bsnz24jx	151	30	of	of	IN
cord-280549-bsnz24jx	151	31	avian	avian	JJ
cord-280549-bsnz24jx	151	32	reovirus	reovirus	NNP
cord-280549-bsnz24jx	151	33	(	(	-LRB-
cord-280549-bsnz24jx	151	34	ARV	ARV	NNP
cord-280549-bsnz24jx	151	35	)	)	-RRB-
cord-280549-bsnz24jx	151	36	to	to	IN
cord-280549-bsnz24jx	151	37	CDK1	CDK1	NNP
cord-280549-bsnz24jx	152	1	(	(	-LRB-
cord-280549-bsnz24jx	152	2	Chiu	Chiu	NNP
cord-280549-bsnz24jx	152	3	et	et	NNP
cord-280549-bsnz24jx	152	4	al	al	NNP
cord-280549-bsnz24jx	152	5	.	.	NNP
cord-280549-bsnz24jx	152	6	,	,	,
cord-280549-bsnz24jx	152	7	2018	2018	CD
cord-280549-bsnz24jx	152	8	)	)	-RRB-
cord-280549-bsnz24jx	152	9	.	.	.
cord-280549-bsnz24jx	153	1	Through	through	IN
cord-280549-bsnz24jx	153	2	GST	gst	NN
cord-280549-bsnz24jx	153	3	-	-	HYPH
cord-280549-bsnz24jx	153	4	pull	pull	VB
cord-280549-bsnz24jx	153	5	down	down	RP
cord-280549-bsnz24jx	153	6	assay	assay	NN
cord-280549-bsnz24jx	153	7	and	and	CC
cord-280549-bsnz24jx	153	8	in	in	IN
cord-280549-bsnz24jx	153	9	vitro	vitro	FW
cord-280549-bsnz24jx	153	10	kinase	kinase	NN
cord-280549-bsnz24jx	153	11	assay	assay	NN
cord-280549-bsnz24jx	153	12	,	,	,
cord-280549-bsnz24jx	153	13	the	the	DT
cord-280549-bsnz24jx	153	14	authors	author	NNS
cord-280549-bsnz24jx	153	15	showed	show	VBD
cord-280549-bsnz24jx	153	16	that	that	IN
cord-280549-bsnz24jx	153	17	p17	p17	NN
cord-280549-bsnz24jx	153	18	competes	compete	VBZ
cord-280549-bsnz24jx	153	19	with	with	IN
cord-280549-bsnz24jx	153	20	cyclin	cyclin	NN
cord-280549-bsnz24jx	153	21	B1	b1	NN
cord-280549-bsnz24jx	153	22	for	for	IN
cord-280549-bsnz24jx	153	23	CDK1	CDK1	NNP
cord-280549-bsnz24jx	153	24	binding	binding	NN
cord-280549-bsnz24jx	153	25	and	and	CC
cord-280549-bsnz24jx	153	26	this	this	DT
cord-280549-bsnz24jx	153	27	direct	direct	JJ
cord-280549-bsnz24jx	153	28	interaction	interaction	NN
cord-280549-bsnz24jx	153	29	of	of	IN
cord-280549-bsnz24jx	153	30	p17	p17	NN
cord-280549-bsnz24jx	153	31	with	with	IN
cord-280549-bsnz24jx	153	32	CDK1	CDK1	NNP
cord-280549-bsnz24jx	153	33	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	153	34	the	the	DT
cord-280549-bsnz24jx	153	35	kinase	kinase	NN
cord-280549-bsnz24jx	153	36	activity	activity	NN
cord-280549-bsnz24jx	153	37	of	of	IN
cord-280549-bsnz24jx	153	38	the	the	DT
cord-280549-bsnz24jx	153	39	latter	latter	JJ
cord-280549-bsnz24jx	153	40	,	,	,
cord-280549-bsnz24jx	153	41	thus	thus	RB
cord-280549-bsnz24jx	153	42	preventing	prevent	VBG
cord-280549-bsnz24jx	153	43	cells	cell	NNS
cord-280549-bsnz24jx	153	44	from	from	IN
cord-280549-bsnz24jx	153	45	entering	enter	VBG
cord-280549-bsnz24jx	153	46	mitosis	mitosis	NN
cord-280549-bsnz24jx	153	47	and	and	CC
cord-280549-bsnz24jx	153	48	enhancing	enhance	VBG
cord-280549-bsnz24jx	153	49	virus	virus	NN
cord-280549-bsnz24jx	153	50	replication	replication	NN
cord-280549-bsnz24jx	153	51	(	(	-LRB-
cord-280549-bsnz24jx	153	52	Chiu	Chiu	NNP
cord-280549-bsnz24jx	153	53	et	et	NNP
cord-280549-bsnz24jx	153	54	al	al	NNP
cord-280549-bsnz24jx	153	55	.	.	NNP
cord-280549-bsnz24jx	153	56	,	,	,
cord-280549-bsnz24jx	153	57	2016	2016	CD
cord-280549-bsnz24jx	154	1	(	(	-LRB-
cord-280549-bsnz24jx	154	2	Chiu	Chiu	NNP
cord-280549-bsnz24jx	154	3	et	et	NNP
cord-280549-bsnz24jx	154	4	al	al	NNP
cord-280549-bsnz24jx	154	5	.	.	NNP
cord-280549-bsnz24jx	154	6	,	,	,
cord-280549-bsnz24jx	154	7	,	,	,
cord-280549-bsnz24jx	154	8	2018	2018	CD
cord-280549-bsnz24jx	154	9	.	.	.
cord-280549-bsnz24jx	155	1	Unlike	unlike	IN
cord-280549-bsnz24jx	155	2	its	-PRON-	PRP$
cord-280549-bsnz24jx	155	3	exquisite	exquisite	JJ
cord-280549-bsnz24jx	155	4	binding	binding	NN
cord-280549-bsnz24jx	155	5	to	to	IN
cord-280549-bsnz24jx	155	6	CDK1	CDK1	NNP
cord-280549-bsnz24jx	156	1	but	but	CC
cord-280549-bsnz24jx	156	2	not	not	RB
cord-280549-bsnz24jx	156	3	cyclin	cyclin	JJ
cord-280549-bsnz24jx	156	4	B1	b1	NN
cord-280549-bsnz24jx	156	5	,	,	,
cord-280549-bsnz24jx	156	6	p17	p17	NN
cord-280549-bsnz24jx	156	7	could	could	MD
cord-280549-bsnz24jx	156	8	also	also	RB
cord-280549-bsnz24jx	156	9	suppress	suppress	VB
cord-280549-bsnz24jx	156	10	CDK2	CDK2	NNP
cord-280549-bsnz24jx	156	11	and	and	CC
cord-280549-bsnz24jx	156	12	CKD4	CKD4	NNP
cord-280549-bsnz24jx	156	13	kinase	kinase	NN
cord-280549-bsnz24jx	156	14	activities	activity	NNS
cord-280549-bsnz24jx	156	15	by	by	IN
cord-280549-bsnz24jx	156	16	direct	direct	JJ
cord-280549-bsnz24jx	156	17	binding	binding	NN
cord-280549-bsnz24jx	156	18	to	to	IN
cord-280549-bsnz24jx	156	19	CDKs	CDKs	NNP
cord-280549-bsnz24jx	156	20	,	,	,
cord-280549-bsnz24jx	156	21	partner	partner	NN
cord-280549-bsnz24jx	156	22	cyclins	cyclin	NNS
cord-280549-bsnz24jx	156	23	,	,	,
cord-280549-bsnz24jx	156	24	and	and	CC
cord-280549-bsnz24jx	156	25	CDK	CDK	NNP
cord-280549-bsnz24jx	156	26	/	/	SYM
cord-280549-bsnz24jx	156	27	cyclin	cyclin	NN
cord-280549-bsnz24jx	156	28	complexes	complex	NNS
cord-280549-bsnz24jx	157	1	(	(	-LRB-
cord-280549-bsnz24jx	157	2	Chiu	Chiu	NNP
cord-280549-bsnz24jx	157	3	et	et	NNP
cord-280549-bsnz24jx	157	4	al	al	NNP
cord-280549-bsnz24jx	157	5	.	.	NNP
cord-280549-bsnz24jx	157	6	,	,	,
cord-280549-bsnz24jx	157	7	2018	2018	CD
cord-280549-bsnz24jx	157	8	)	)	-RRB-
cord-280549-bsnz24jx	157	9	.	.	.
cord-280549-bsnz24jx	158	1	Cyclin	Cyclin	NNP
cord-280549-bsnz24jx	158	2	-	-	HYPH
cord-280549-bsnz24jx	158	3	dependent	dependent	JJ
cord-280549-bsnz24jx	158	4	kinase	kinase	NN
cord-280549-bsnz24jx	158	5	inhibitors	inhibitor	NNS
cord-280549-bsnz24jx	158	6	are	be	VBP
cord-280549-bsnz24jx	158	7	a	a	DT
cord-280549-bsnz24jx	158	8	family	family	NN
cord-280549-bsnz24jx	158	9	of	of	IN
cord-280549-bsnz24jx	158	10	proteins	protein	NNS
cord-280549-bsnz24jx	158	11	that	that	IN
cord-280549-bsnz24jx	158	12	,	,	,
cord-280549-bsnz24jx	158	13	acting	act	VBG
cord-280549-bsnz24jx	158	14	through	through	IN
cord-280549-bsnz24jx	158	15	separate	separate	JJ
cord-280549-bsnz24jx	158	16	pathways	pathway	NNS
cord-280549-bsnz24jx	158	17	,	,	,
cord-280549-bsnz24jx	158	18	determine	determine	VBP
cord-280549-bsnz24jx	158	19	in	in	IN
cord-280549-bsnz24jx	158	20	cooperation	cooperation	NN
cord-280549-bsnz24jx	158	21	with	with	IN
cord-280549-bsnz24jx	158	22	cyclins	cyclin	NNS
cord-280549-bsnz24jx	158	23	and	and	CC
cord-280549-bsnz24jx	158	24	CDKs	cdk	NNS
cord-280549-bsnz24jx	158	25	the	the	DT
cord-280549-bsnz24jx	158	26	decision	decision	NN
cord-280549-bsnz24jx	158	27	of	of	IN
cord-280549-bsnz24jx	158	28	the	the	DT
cord-280549-bsnz24jx	158	29	cell	cell	NN
cord-280549-bsnz24jx	158	30	to	to	TO
cord-280549-bsnz24jx	158	31	progress	progress	VB
cord-280549-bsnz24jx	158	32	through	through	IN
cord-280549-bsnz24jx	158	33	the	the	DT
cord-280549-bsnz24jx	158	34	cell	cell	NN
cord-280549-bsnz24jx	158	35	cycle	cycle	NN
cord-280549-bsnz24jx	158	36	.	.	.
cord-280549-bsnz24jx	159	1	The	the	DT
cord-280549-bsnz24jx	159	2	adenovirus	adenovirus	NN
cord-280549-bsnz24jx	159	3	early	early	JJ
cord-280549-bsnz24jx	159	4	region	region	NN
cord-280549-bsnz24jx	159	5	1A	1a	CD
cord-280549-bsnz24jx	160	1	(	(	-LRB-
cord-280549-bsnz24jx	160	2	E1A	e1a	LS
cord-280549-bsnz24jx	160	3	)	)	-RRB-
cord-280549-bsnz24jx	160	4	protein	protein	NN
cord-280549-bsnz24jx	160	5	displays	display	VBZ
cord-280549-bsnz24jx	160	6	the	the	DT
cord-280549-bsnz24jx	160	7	ability	ability	NN
cord-280549-bsnz24jx	160	8	to	to	TO
cord-280549-bsnz24jx	160	9	bind	bind	VB
cord-280549-bsnz24jx	160	10	multiple	multiple	JJ
cord-280549-bsnz24jx	160	11	host	host	NN
cord-280549-bsnz24jx	160	12	factors	factor	NNS
cord-280549-bsnz24jx	160	13	for	for	IN
cord-280549-bsnz24jx	160	14	the	the	DT
cord-280549-bsnz24jx	160	15	manipulation	manipulation	NN
cord-280549-bsnz24jx	160	16	of	of	IN
cord-280549-bsnz24jx	160	17	cell	cell	NN
cord-280549-bsnz24jx	160	18	cycle	cycle	NN
cord-280549-bsnz24jx	160	19	progression	progression	NN
cord-280549-bsnz24jx	160	20	.	.	.
cord-280549-bsnz24jx	161	1	Binding	binding	NN
cord-280549-bsnz24jx	161	2	of	of	IN
cord-280549-bsnz24jx	161	3	E1A	e1a	NN
cord-280549-bsnz24jx	161	4	to	to	IN
cord-280549-bsnz24jx	161	5	p27	p27	NN
cord-280549-bsnz24jx	161	6	KIP1	KIP1	NNP
cord-280549-bsnz24jx	161	7	blocks	block	VBZ
cord-280549-bsnz24jx	161	8	its	-PRON-	PRP$
cord-280549-bsnz24jx	161	9	inhibitiononCDK2	inhibitiononcdk2	JJ
cord-280549-bsnz24jx	161	10	kinase	kinase	NN
cord-280549-bsnz24jx	161	11	activity	activity	NN
cord-280549-bsnz24jx	161	12	,	,	,
cord-280549-bsnz24jx	161	13	overcoming	overcome	VBG
cord-280549-bsnz24jx	161	14	transforming	transform	VBG
cord-280549-bsnz24jx	161	15	growth	growth	NN
cord-280549-bsnz24jx	161	16	factor	factor	NN
cord-280549-bsnz24jx	161	17	(	(	-LRB-
cord-280549-bsnz24jx	161	18	TGF)-β	TGF)-β	NNP
cord-280549-bsnz24jx	161	19	-	-	HYPH
cord-280549-bsnz24jx	161	20	induced	induce	VBN
cord-280549-bsnz24jx	161	21	cell	cell	NN
cord-280549-bsnz24jx	161	22	cycle	cycle	NN
cord-280549-bsnz24jx	161	23	arrest	arrest	NN
cord-280549-bsnz24jx	161	24	in	in	IN
cord-280549-bsnz24jx	161	25	late	late	JJ
cord-280549-bsnz24jx	161	26	G1	G1	NNP
cord-280549-bsnz24jx	161	27	phase	phase	NN
cord-280549-bsnz24jx	161	28	(	(	-LRB-
cord-280549-bsnz24jx	161	29	Mal	Mal	NNP
cord-280549-bsnz24jx	161	30	et	et	FW
cord-280549-bsnz24jx	161	31	al	al	NNP
cord-280549-bsnz24jx	161	32	.	.	NNP
cord-280549-bsnz24jx	161	33	,	,	,
cord-280549-bsnz24jx	161	34	1996	1996	CD
cord-280549-bsnz24jx	161	35	)	)	-RRB-
cord-280549-bsnz24jx	161	36	.	.	.
cord-280549-bsnz24jx	162	1	This	this	DT
cord-280549-bsnz24jx	162	2	provided	provide	VBD
cord-280549-bsnz24jx	162	3	the	the	DT
cord-280549-bsnz24jx	162	4	first	first	JJ
cord-280549-bsnz24jx	162	5	evidence	evidence	NN
cord-280549-bsnz24jx	162	6	that	that	IN
cord-280549-bsnz24jx	162	7	a	a	DT
cord-280549-bsnz24jx	162	8	viral	viral	JJ
cord-280549-bsnz24jx	162	9	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	162	10	could	could	MD
cord-280549-bsnz24jx	162	11	manipulate	manipulate	VB
cord-280549-bsnz24jx	162	12	the	the	DT
cord-280549-bsnz24jx	162	13	cell	cell	NN
cord-280549-bsnz24jx	162	14	cycle	cycle	NN
cord-280549-bsnz24jx	162	15	by	by	IN
cord-280549-bsnz24jx	162	16	counteracting	counteract	VBG
cord-280549-bsnz24jx	162	17	an	an	DT
cord-280549-bsnz24jx	162	18	inhibitor	inhibitor	NN
cord-280549-bsnz24jx	162	19	of	of	IN
cord-280549-bsnz24jx	162	20	CDKs	cdk	NNS
cord-280549-bsnz24jx	162	21	.	.	.
cord-280549-bsnz24jx	163	1	In	in	IN
cord-280549-bsnz24jx	163	2	addition	addition	NN
cord-280549-bsnz24jx	163	3	to	to	IN
cord-280549-bsnz24jx	163	4	its	-PRON-	PRP$
cord-280549-bsnz24jx	163	5	association	association	NN
cord-280549-bsnz24jx	163	6	with	with	IN
cord-280549-bsnz24jx	163	7	cyclins	cyclin	NNS
cord-280549-bsnz24jx	163	8	,	,	,
cord-280549-bsnz24jx	163	9	HTLV-1	HTLV-1	NNP
cord-280549-bsnz24jx	163	10	Tax	Tax	NNP
cord-280549-bsnz24jx	163	11	is	be	VBZ
cord-280549-bsnz24jx	163	12	also	also	RB
cord-280549-bsnz24jx	163	13	able	able	JJ
cord-280549-bsnz24jx	163	14	to	to	TO
cord-280549-bsnz24jx	163	15	interact	interact	VB
cord-280549-bsnz24jx	163	16	with	with	IN
cord-280549-bsnz24jx	163	17	p16	p16	NN
cord-280549-bsnz24jx	163	18	INK4A	INK4A	NNS
cord-280549-bsnz24jx	163	19	and	and	CC
cord-280549-bsnz24jx	163	20	relieve	relieve	VB
cord-280549-bsnz24jx	163	21	p16	p16	CD
cord-280549-bsnz24jx	163	22	INK4A	INK4A	NNS
cord-280549-bsnz24jx	163	23	-imposed	-imposed	JJ
cord-280549-bsnz24jx	163	24	blockage	blockage	NN
cord-280549-bsnz24jx	163	25	of	of	IN
cord-280549-bsnz24jx	163	26	G1	G1	NNP
cord-280549-bsnz24jx	163	27	to	to	IN
cord-280549-bsnz24jx	163	28	S	s	NN
cord-280549-bsnz24jx	163	29	transition	transition	NN
cord-280549-bsnz24jx	163	30	,	,	,
cord-280549-bsnz24jx	163	31	demonstrated	demonstrate	VBN
cord-280549-bsnz24jx	163	32	by	by	IN
cord-280549-bsnz24jx	163	33	the	the	DT
cord-280549-bsnz24jx	163	34	finding	finding	NN
cord-280549-bsnz24jx	163	35	that	that	IN
cord-280549-bsnz24jx	163	36	binding	bind	VBG
cord-280549-bsnz24jx	163	37	-	-	HYPH
cord-280549-bsnz24jx	163	38	deficient	deficient	JJ
cord-280549-bsnz24jx	163	39	Tax	tax	NN
cord-280549-bsnz24jx	163	40	could	could	MD
cord-280549-bsnz24jx	163	41	not	not	RB
cord-280549-bsnz24jx	163	42	protect	protect	VB
cord-280549-bsnz24jx	163	43	CDK4	CDK4	NNP
cord-280549-bsnz24jx	163	44	from	from	IN
cord-280549-bsnz24jx	163	45	the	the	DT
cord-280549-bsnz24jx	163	46	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	163	47	effect	effect	NN
cord-280549-bsnz24jx	163	48	of	of	IN
cord-280549-bsnz24jx	163	49	p16	p16	NN
cord-280549-bsnz24jx	163	50	INK4A	INK4A	NNS
cord-280549-bsnz24jx	164	1	(	(	-LRB-
cord-280549-bsnz24jx	164	2	Suzuki	Suzuki	NNP
cord-280549-bsnz24jx	164	3	et	et	FW
cord-280549-bsnz24jx	164	4	al	al	NNP
cord-280549-bsnz24jx	164	5	.	.	.
cord-280549-bsnz24jx	165	1	,	,	,
cord-280549-bsnz24jx	165	2	1996	1996	CD
cord-280549-bsnz24jx	165	3	;	;	:
cord-280549-bsnz24jx	165	4	Low	Low	NNP
cord-280549-bsnz24jx	165	5	et	et	FW
cord-280549-bsnz24jx	165	6	al	al	NNP
cord-280549-bsnz24jx	165	7	.	.	NNP
cord-280549-bsnz24jx	165	8	,	,	,
cord-280549-bsnz24jx	165	9	1997	1997	CD
cord-280549-bsnz24jx	165	10	)	)	-RRB-
cord-280549-bsnz24jx	165	11	.	.	.
cord-280549-bsnz24jx	166	1	Suzuki	Suzuki	NNP
cord-280549-bsnz24jx	166	2	et	et	NNP
cord-280549-bsnz24jx	166	3	al	al	NNP
cord-280549-bsnz24jx	166	4	.	.	NNP
cord-280549-bsnz24jx	166	5	found	find	VBD
cord-280549-bsnz24jx	166	6	that	that	IN
cord-280549-bsnz24jx	166	7	the	the	DT
cord-280549-bsnz24jx	166	8	co	co	NN
cord-280549-bsnz24jx	166	9	-	-	NN
cord-280549-bsnz24jx	166	10	precipitation	precipitation	NN
cord-280549-bsnz24jx	166	11	of	of	IN
cord-280549-bsnz24jx	166	12	p16	p16	NN
cord-280549-bsnz24jx	166	13	INK4A	INK4A	NNS
cord-280549-bsnz24jx	166	14	by	by	IN
cord-280549-bsnz24jx	166	15	CDK4	CDK4	NNP
cord-280549-bsnz24jx	166	16	was	be	VBD
cord-280549-bsnz24jx	166	17	drastically	drastically	RB
cord-280549-bsnz24jx	166	18	reduced	reduce	VBN
cord-280549-bsnz24jx	166	19	in	in	IN
cord-280549-bsnz24jx	166	20	the	the	DT
cord-280549-bsnz24jx	166	21	presence	presence	NN
cord-280549-bsnz24jx	166	22	of	of	IN
cord-280549-bsnz24jx	166	23	Tax	Tax	NNP
cord-280549-bsnz24jx	166	24	,	,	,
cord-280549-bsnz24jx	166	25	providing	provide	VBG
cord-280549-bsnz24jx	166	26	direct	direct	JJ
cord-280549-bsnz24jx	166	27	proof	proof	NN
cord-280549-bsnz24jx	166	28	that	that	IN
cord-280549-bsnz24jx	166	29	Tax	Tax	NNP
cord-280549-bsnz24jx	166	30	activates	activate	VBZ
cord-280549-bsnz24jx	166	31	CDK4	CDK4	NNP
cord-280549-bsnz24jx	166	32	by	by	IN
cord-280549-bsnz24jx	166	33	disabling	disable	VBG
cord-280549-bsnz24jx	166	34	the	the	DT
cord-280549-bsnz24jx	166	35	formation	formation	NN
cord-280549-bsnz24jx	166	36	of	of	IN
cord-280549-bsnz24jx	166	37	p16	p16	NN
cord-280549-bsnz24jx	167	1	INK4A	INK4A	NNP
cord-280549-bsnz24jx	167	2	-CDK4	-CDK4	NNP
cord-280549-bsnz24jx	168	1	complex	complex	JJ
cord-280549-bsnz24jx	169	1	(	(	-LRB-
cord-280549-bsnz24jx	169	2	Suzuki	Suzuki	NNP
cord-280549-bsnz24jx	169	3	et	et	FW
cord-280549-bsnz24jx	169	4	al	al	NNP
cord-280549-bsnz24jx	169	5	.	.	NNP
cord-280549-bsnz24jx	169	6	,	,	,
cord-280549-bsnz24jx	169	7	1996	1996	CD
cord-280549-bsnz24jx	169	8	)	)	-RRB-
cord-280549-bsnz24jx	169	9	.	.	.
cord-280549-bsnz24jx	170	1	In	in	IN
cord-280549-bsnz24jx	170	2	a	a	DT
cord-280549-bsnz24jx	170	3	similar	similar	JJ
cord-280549-bsnz24jx	170	4	manner	manner	NN
cord-280549-bsnz24jx	170	5	,	,	,
cord-280549-bsnz24jx	170	6	Tax	tax	NN
cord-280549-bsnz24jx	170	7	restores	restore	VBZ
cord-280549-bsnz24jx	170	8	CDK4	CDK4	NNP
cord-280549-bsnz24jx	170	9	activity	activity	NN
cord-280549-bsnz24jx	170	10	through	through	IN
cord-280549-bsnz24jx	170	11	interaction	interaction	NN
cord-280549-bsnz24jx	170	12	with	with	IN
cord-280549-bsnz24jx	170	13	p15	p15	NN
cord-280549-bsnz24jx	170	14	INK4B	INK4B	NNS
cord-280549-bsnz24jx	170	15	,	,	,
cord-280549-bsnz24jx	170	16	further	further	RB
cord-280549-bsnz24jx	170	17	contributing	contribute	VBG
cord-280549-bsnz24jx	170	18	to	to	IN
cord-280549-bsnz24jx	170	19	the	the	DT
cord-280549-bsnz24jx	170	20	immortalization	immortalization	NN
cord-280549-bsnz24jx	170	21	of	of	IN
cord-280549-bsnz24jx	170	22	T	t	NN
cord-280549-bsnz24jx	170	23	cells	cell	NNS
cord-280549-bsnz24jx	170	24	(	(	-LRB-
cord-280549-bsnz24jx	170	25	Suzuki	Suzuki	NNP
cord-280549-bsnz24jx	170	26	et	et	FW
cord-280549-bsnz24jx	170	27	al	al	NNP
cord-280549-bsnz24jx	170	28	.	.	NNP
cord-280549-bsnz24jx	170	29	,	,	,
cord-280549-bsnz24jx	170	30	1999	1999	CD
cord-280549-bsnz24jx	170	31	)	)	-RRB-
cord-280549-bsnz24jx	170	32	.	.	.
cord-280549-bsnz24jx	171	1	Interestingly	interestingly	RB
cord-280549-bsnz24jx	171	2	,	,	,
cord-280549-bsnz24jx	171	3	while	while	IN
cord-280549-bsnz24jx	171	4	Tax	tax	NN
cord-280549-bsnz24jx	171	5	directly	directly	RB
cord-280549-bsnz24jx	171	6	antagonizes	antagonize	VBZ
cord-280549-bsnz24jx	171	7	p16	p16	NN
cord-280549-bsnz24jx	171	8	INK4A	INK4A	NNS
cord-280549-bsnz24jx	171	9	and	and	CC
cord-280549-bsnz24jx	171	10	p15	p15	NNP
cord-280549-bsnz24jx	171	11	INK4B	INK4B	VBZ
cord-280549-bsnz24jx	171	12	through	through	IN
cord-280549-bsnz24jx	171	13	protein	protein	NN
cord-280549-bsnz24jx	171	14	-	-	HYPH
cord-280549-bsnz24jx	171	15	protein	protein	NN
cord-280549-bsnz24jx	171	16	interaction	interaction	NN
cord-280549-bsnz24jx	171	17	,	,	,
cord-280549-bsnz24jx	171	18	it	-PRON-	PRP
cord-280549-bsnz24jx	171	19	utilizes	utilize	VBZ
cord-280549-bsnz24jx	171	20	a	a	DT
cord-280549-bsnz24jx	171	21	different	different	JJ
cord-280549-bsnz24jx	171	22	mechanism	mechanism	NN
cord-280549-bsnz24jx	171	23	to	to	TO
cord-280549-bsnz24jx	171	24	repress	repress	VB
cord-280549-bsnz24jx	171	25	p18	p18	CD
cord-280549-bsnz24jx	171	26	INK4C	ink4c	NN
cord-280549-bsnz24jx	171	27	transcription	transcription	NN
cord-280549-bsnz24jx	171	28	and	and	CC
cord-280549-bsnz24jx	171	29	further	further	RB
cord-280549-bsnz24jx	171	30	promote	promote	VB
cord-280549-bsnz24jx	171	31	cell	cell	NN
cord-280549-bsnz24jx	171	32	transformation	transformation	NN
cord-280549-bsnz24jx	171	33	(	(	-LRB-
cord-280549-bsnz24jx	171	34	Suzuki	Suzuki	NNP
cord-280549-bsnz24jx	171	35	et	et	FW
cord-280549-bsnz24jx	171	36	al	al	NNP
cord-280549-bsnz24jx	171	37	.	.	NNP
cord-280549-bsnz24jx	171	38	,	,	,
cord-280549-bsnz24jx	171	39	1999	1999	CD
cord-280549-bsnz24jx	171	40	)	)	-RRB-
cord-280549-bsnz24jx	171	41	.	.	.
cord-280549-bsnz24jx	172	1	It	-PRON-	PRP
cord-280549-bsnz24jx	172	2	was	be	VBD
cord-280549-bsnz24jx	172	3	reported	report	VBN
cord-280549-bsnz24jx	172	4	that	that	IN
cord-280549-bsnz24jx	172	5	p21	p21	NN
cord-280549-bsnz24jx	172	6	WAF1	WAF1	NNP
cord-280549-bsnz24jx	172	7	/	/	SYM
cord-280549-bsnz24jx	172	8	CIP1	CIP1	NNP
cord-280549-bsnz24jx	172	9	could	could	MD
cord-280549-bsnz24jx	172	10	block	block	VB
cord-280549-bsnz24jx	172	11	the	the	DT
cord-280549-bsnz24jx	172	12	interaction	interaction	NN
cord-280549-bsnz24jx	172	13	between	between	IN
cord-280549-bsnz24jx	172	14	cell	cell	NN
cord-280549-bsnz24jx	172	15	division	division	NN
cord-280549-bsnz24jx	172	16	cycle	cycle	NN
cord-280549-bsnz24jx	172	17	25C	25c	NN
cord-280549-bsnz24jx	172	18	(	(	-LRB-
cord-280549-bsnz24jx	172	19	Cdc25C	Cdc25C	NNP
cord-280549-bsnz24jx	172	20	)	)	-RRB-
cord-280549-bsnz24jx	172	21	,	,	,
cord-280549-bsnz24jx	172	22	a	a	DT
cord-280549-bsnz24jx	172	23	phosphatase	phosphatase	NN
cord-280549-bsnz24jx	172	24	of	of	IN
cord-280549-bsnz24jx	172	25	CDK1	CDK1	NNP
cord-280549-bsnz24jx	172	26	that	that	WDT
cord-280549-bsnz24jx	172	27	activates	activate	VBZ
cord-280549-bsnz24jx	172	28	the	the	DT
cord-280549-bsnz24jx	172	29	CDK1	CDK1	NNP
cord-280549-bsnz24jx	172	30	/	/	SYM
cord-280549-bsnz24jx	172	31	cyclin	cyclin	NN
cord-280549-bsnz24jx	172	32	B1	b1	NN
cord-280549-bsnz24jx	172	33	complex	complex	NN
cord-280549-bsnz24jx	173	1	(	(	-LRB-
cord-280549-bsnz24jx	173	2	Strausfeld	Strausfeld	NNP
cord-280549-bsnz24jx	173	3	et	et	FW
cord-280549-bsnz24jx	173	4	al	al	NNP
cord-280549-bsnz24jx	173	5	.	.	NNP
cord-280549-bsnz24jx	173	6	,	,	,
cord-280549-bsnz24jx	173	7	1991	1991	CD
cord-280549-bsnz24jx	173	8	)	)	-RRB-
cord-280549-bsnz24jx	173	9	,	,	,
cord-280549-bsnz24jx	173	10	and	and	CC
cord-280549-bsnz24jx	173	11	proliferating	proliferate	VBG
cord-280549-bsnz24jx	173	12	cell	cell	NN
cord-280549-bsnz24jx	173	13	nuclear	nuclear	JJ
cord-280549-bsnz24jx	173	14	antigen	antigen	NN
cord-280549-bsnz24jx	173	15	(	(	-LRB-
cord-280549-bsnz24jx	173	16	PCNA	PCNA	NNP
cord-280549-bsnz24jx	173	17	)	)	-RRB-
cord-280549-bsnz24jx	173	18	by	by	IN
cord-280549-bsnz24jx	173	19	competing	compete	VBG
cord-280549-bsnz24jx	173	20	with	with	IN
cord-280549-bsnz24jx	173	21	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	173	22	for	for	IN
cord-280549-bsnz24jx	173	23	PCNA	PCNA	NNS
cord-280549-bsnz24jx	173	24	binding	bind	VBG
cord-280549-bsnz24jx	173	25	.	.	.
cord-280549-bsnz24jx	174	1	This	this	DT
cord-280549-bsnz24jx	174	2	observation	observation	NN
cord-280549-bsnz24jx	174	3	points	point	VBZ
cord-280549-bsnz24jx	174	4	to	to	IN
cord-280549-bsnz24jx	174	5	a	a	DT
cord-280549-bsnz24jx	174	6	role	role	NN
cord-280549-bsnz24jx	174	7	of	of	IN
cord-280549-bsnz24jx	174	8	p21	p21	NN
cord-280549-bsnz24jx	174	9	WAF1	WAF1	NNP
cord-280549-bsnz24jx	174	10	/	/	SYM
cord-280549-bsnz24jx	174	11	CIP1	CIP1	NNP
cord-280549-bsnz24jx	174	12	in	in	IN
cord-280549-bsnz24jx	174	13	G2	G2	NNP
cord-280549-bsnz24jx	174	14	cell	cell	NN
cord-280549-bsnz24jx	174	15	cycle	cycle	NN
cord-280549-bsnz24jx	174	16	arrest	arrest	NN
cord-280549-bsnz24jx	174	17	upon	upon	IN
cord-280549-bsnz24jx	174	18	DNA	dna	NN
cord-280549-bsnz24jx	174	19	damage	damage	NN
cord-280549-bsnz24jx	175	1	(	(	-LRB-
cord-280549-bsnz24jx	175	2	Ando	Ando	NNP
cord-280549-bsnz24jx	175	3	et	et	NNP
cord-280549-bsnz24jx	175	4	al	al	NNP
cord-280549-bsnz24jx	175	5	.	.	NNP
cord-280549-bsnz24jx	175	6	,	,	,
cord-280549-bsnz24jx	175	7	2001	2001	CD
cord-280549-bsnz24jx	175	8	)	)	-RRB-
cord-280549-bsnz24jx	175	9	.	.	.
cord-280549-bsnz24jx	176	1	Formation	formation	NN
cord-280549-bsnz24jx	176	2	of	of	IN
cord-280549-bsnz24jx	176	3	a	a	DT
cord-280549-bsnz24jx	176	4	complex	complex	NN
cord-280549-bsnz24jx	176	5	between	between	IN
cord-280549-bsnz24jx	176	6	the	the	DT
cord-280549-bsnz24jx	176	7	core	core	NN
cord-280549-bsnz24jx	176	8	protein	protein	NN
cord-280549-bsnz24jx	176	9	of	of	IN
cord-280549-bsnz24jx	176	10	hepatitis	hepatitis	NNP
cord-280549-bsnz24jx	176	11	C	C	NNP
cord-280549-bsnz24jx	176	12	virus	virus	NN
cord-280549-bsnz24jx	176	13	(	(	-LRB-
cord-280549-bsnz24jx	176	14	HCV	HCV	NNP
cord-280549-bsnz24jx	176	15	)	)	-RRB-
cord-280549-bsnz24jx	176	16	,	,	,
cord-280549-bsnz24jx	176	17	which	which	WDT
cord-280549-bsnz24jx	176	18	plays	play	VBZ
cord-280549-bsnz24jx	176	19	an	an	DT
cord-280549-bsnz24jx	176	20	important	important	JJ
cord-280549-bsnz24jx	176	21	role	role	NN
cord-280549-bsnz24jx	176	22	in	in	IN
cord-280549-bsnz24jx	176	23	the	the	DT
cord-280549-bsnz24jx	176	24	development	development	NN
cord-280549-bsnz24jx	176	25	of	of	IN
cord-280549-bsnz24jx	176	26	hepatocellular	hepatocellular	JJ
cord-280549-bsnz24jx	176	27	carcinomas	carcinoma	NNS
cord-280549-bsnz24jx	176	28	,	,	,
cord-280549-bsnz24jx	176	29	and	and	CC
cord-280549-bsnz24jx	176	30	p21	p21	NN
cord-280549-bsnz24jx	176	31	WAF1	WAF1	NNP
cord-280549-bsnz24jx	176	32	/	/	SYM
cord-280549-bsnz24jx	176	33	CIP1	CIP1	NNP
cord-280549-bsnz24jx	176	34	was	be	VBD
cord-280549-bsnz24jx	176	35	mapped	map	VBN
cord-280549-bsnz24jx	176	36	to	to	IN
cord-280549-bsnz24jx	176	37	the	the	DT
cord-280549-bsnz24jx	176	38	C	c	NN
cord-280549-bsnz24jx	176	39	-	-	HYPH
cord-280549-bsnz24jx	176	40	terminus	terminus	NN
cord-280549-bsnz24jx	176	41	of	of	IN
cord-280549-bsnz24jx	176	42	this	this	DT
cord-280549-bsnz24jx	176	43	CKI	CKI	NNP
cord-280549-bsnz24jx	176	44	,	,	,
cord-280549-bsnz24jx	176	45	a	a	DT
cord-280549-bsnz24jx	176	46	region	region	NN
cord-280549-bsnz24jx	176	47	in	in	IN
cord-280549-bsnz24jx	176	48	the	the	DT
cord-280549-bsnz24jx	176	49	close	close	JJ
cord-280549-bsnz24jx	176	50	vicinity	vicinity	NN
cord-280549-bsnz24jx	176	51	of	of	IN
cord-280549-bsnz24jx	176	52	the	the	DT
cord-280549-bsnz24jx	176	53	PCNA	PCNA	NNP
cord-280549-bsnz24jx	176	54	binding	bind	VBG
cord-280549-bsnz24jx	176	55	site	site	NN
cord-280549-bsnz24jx	176	56	of	of	IN
cord-280549-bsnz24jx	176	57	p21	p21	NN
cord-280549-bsnz24jx	176	58	WAF1	WAF1	NNP
cord-280549-bsnz24jx	176	59	/	/	SYM
cord-280549-bsnz24jx	176	60	CIP1	CIP1	NNP
cord-280549-bsnz24jx	176	61	.	.	.
cord-280549-bsnz24jx	177	1	In	in	IN
cord-280549-bsnz24jx	177	2	vitro	vitro	FW
cord-280549-bsnz24jx	177	3	experiments	experiment	NNS
cord-280549-bsnz24jx	177	4	revealed	reveal	VBD
cord-280549-bsnz24jx	177	5	that	that	IN
cord-280549-bsnz24jx	177	6	a	a	DT
cord-280549-bsnz24jx	177	7	competition	competition	NN
cord-280549-bsnz24jx	177	8	exists	exist	VBZ
cord-280549-bsnz24jx	177	9	between	between	IN
cord-280549-bsnz24jx	177	10	core	core	NN
cord-280549-bsnz24jx	177	11	protein	protein	NN
cord-280549-bsnz24jx	177	12	and	and	CC
cord-280549-bsnz24jx	177	13	PCNA	PCNA	NNP
cord-280549-bsnz24jx	177	14	for	for	IN
cord-280549-bsnz24jx	177	15	the	the	DT
cord-280549-bsnz24jx	177	16	association	association	NN
cord-280549-bsnz24jx	177	17	with	with	IN
cord-280549-bsnz24jx	177	18	p21	p21	NNP
cord-280549-bsnz24jx	177	19	WAF1	WAF1	NNP
cord-280549-bsnz24jx	177	20	/	/	SYM
cord-280549-bsnz24jx	177	21	CIP1	CIP1	NNP
cord-280549-bsnz24jx	177	22	.	.	.
cord-280549-bsnz24jx	178	1	It	-PRON-	PRP
cord-280549-bsnz24jx	178	2	is	be	VBZ
cord-280549-bsnz24jx	178	3	plausible	plausible	JJ
cord-280549-bsnz24jx	178	4	to	to	TO
cord-280549-bsnz24jx	178	5	speculate	speculate	VB
cord-280549-bsnz24jx	178	6	that	that	IN
cord-280549-bsnz24jx	178	7	,	,	,
cord-280549-bsnz24jx	178	8	in	in	IN
cord-280549-bsnz24jx	178	9	the	the	DT
cord-280549-bsnz24jx	178	10	case	case	NN
cord-280549-bsnz24jx	178	11	of	of	IN
cord-280549-bsnz24jx	178	12	HCV	HCV	NNP
cord-280549-bsnz24jx	178	13	infection	infection	NN
cord-280549-bsnz24jx	178	14	,	,	,
cord-280549-bsnz24jx	178	15	expression	expression	NN
cord-280549-bsnz24jx	178	16	of	of	IN
cord-280549-bsnz24jx	178	17	core	core	NN
cord-280549-bsnz24jx	178	18	protein	protein	NN
cord-280549-bsnz24jx	178	19	may	may	MD
cord-280549-bsnz24jx	178	20	disrupt	disrupt	VB
cord-280549-bsnz24jx	178	21	PCNA	PCNA	NNP
cord-280549-bsnz24jx	178	22	-	-	HYPH
cord-280549-bsnz24jx	178	23	p21	p21	NN
cord-280549-bsnz24jx	178	24	WAF1	WAF1	NNP
cord-280549-bsnz24jx	178	25	/	/	SYM
cord-280549-bsnz24jx	178	26	CIP1	CIP1	NNP
cord-280549-bsnz24jx	178	27	binding	binding	NN
cord-280549-bsnz24jx	178	28	,	,	,
cord-280549-bsnz24jx	178	29	leading	lead	VBG
cord-280549-bsnz24jx	178	30	to	to	IN
cord-280549-bsnz24jx	178	31	impaired	impaired	JJ
cord-280549-bsnz24jx	178	32	cell	cell	NN
cord-280549-bsnz24jx	178	33	cycle	cycle	NN
cord-280549-bsnz24jx	178	34	arrest	arrest	NN
cord-280549-bsnz24jx	178	35	in	in	IN
cord-280549-bsnz24jx	178	36	G2	G2	NNP
cord-280549-bsnz24jx	178	37	and	and	CC
cord-280549-bsnz24jx	178	38	DNA	dna	NN
cord-280549-bsnz24jx	178	39	repair	repair	NN
cord-280549-bsnz24jx	178	40	in	in	IN
cord-280549-bsnz24jx	178	41	response	response	NN
cord-280549-bsnz24jx	178	42	to	to	IN
cord-280549-bsnz24jx	178	43	damage	damage	NN
cord-280549-bsnz24jx	178	44	signals	signal	NNS
cord-280549-bsnz24jx	178	45	.	.	.
cord-280549-bsnz24jx	179	1	Other	other	JJ
cord-280549-bsnz24jx	179	2	examples	example	NNS
cord-280549-bsnz24jx	179	3	of	of	IN
cord-280549-bsnz24jx	179	4	viral	viral	JJ
cord-280549-bsnz24jx	179	5	protein	protein	NN
cord-280549-bsnz24jx	179	6	-	-	HYPH
cord-280549-bsnz24jx	179	7	mediated	mediate	VBN
cord-280549-bsnz24jx	179	8	inhibition	inhibition	NN
cord-280549-bsnz24jx	179	9	of	of	IN
cord-280549-bsnz24jx	179	10	CKIs	cki	NNS
cord-280549-bsnz24jx	179	11	include	include	VBP
cord-280549-bsnz24jx	179	12	the	the	DT
cord-280549-bsnz24jx	179	13	E7	E7	NNP
cord-280549-bsnz24jx	179	14	oncoprotein	oncoprotein	NN
cord-280549-bsnz24jx	179	15	of	of	IN
cord-280549-bsnz24jx	179	16	HPV-16	HPV-16	NNP
cord-280549-bsnz24jx	179	17	and	and	CC
cord-280549-bsnz24jx	179	18	the	the	DT
cord-280549-bsnz24jx	179	19	immediate	immediate	JJ
cord-280549-bsnz24jx	179	20	-	-	HYPH
cord-280549-bsnz24jx	179	21	early	early	JJ
cord-280549-bsnz24jx	179	22	(	(	-LRB-
cord-280549-bsnz24jx	179	23	IE	IE	NNP
cord-280549-bsnz24jx	179	24	)	)	-RRB-
cord-280549-bsnz24jx	179	25	protein	protein	NN
cord-280549-bsnz24jx	179	26	IE2	ie2	NN
cord-280549-bsnz24jx	179	27	-	-	HYPH
cord-280549-bsnz24jx	179	28	86	86	CD
cord-280549-bsnz24jx	179	29	of	of	IN
cord-280549-bsnz24jx	179	30	human	human	JJ
cord-280549-bsnz24jx	179	31	cytomegalovirus	cytomegalovirus	NN
cord-280549-bsnz24jx	179	32	(	(	-LRB-
cord-280549-bsnz24jx	179	33	HCMV	HCMV	NNP
cord-280549-bsnz24jx	179	34	)	)	-RRB-
cord-280549-bsnz24jx	180	1	(	(	-LRB-
cord-280549-bsnz24jx	180	2	Zerfass	Zerfass	NNP
cord-280549-bsnz24jx	180	3	-	-	HYPH
cord-280549-bsnz24jx	180	4	Thome	Thome	NNP
cord-280549-bsnz24jx	180	5	et	et	FW
cord-280549-bsnz24jx	180	6	al	al	NNP
cord-280549-bsnz24jx	180	7	.	.	.
cord-280549-bsnz24jx	181	1	,	,	,
cord-280549-bsnz24jx	181	2	1996	1996	CD
cord-280549-bsnz24jx	181	3	;	;	:
cord-280549-bsnz24jx	181	4	Funk	Funk	NNP
cord-280549-bsnz24jx	181	5	et	et	NNP
cord-280549-bsnz24jx	181	6	al	al	NNP
cord-280549-bsnz24jx	181	7	.	.	NNP
cord-280549-bsnz24jx	181	8	,	,	,
cord-280549-bsnz24jx	181	9	1997	1997	CD
cord-280549-bsnz24jx	181	10	;	;	:
cord-280549-bsnz24jx	181	11	Jones	Jones	NNP
cord-280549-bsnz24jx	181	12	et	et	NNP
cord-280549-bsnz24jx	181	13	al	al	NNP
cord-280549-bsnz24jx	181	14	.	.	NNP
cord-280549-bsnz24jx	181	15	,	,	,
cord-280549-bsnz24jx	181	16	1997	1997	CD
cord-280549-bsnz24jx	181	17	;	;	:
cord-280549-bsnz24jx	181	18	Sinclair	Sinclair	NNP
cord-280549-bsnz24jx	181	19	et	et	NNP
cord-280549-bsnz24jx	181	20	al	al	NNP
cord-280549-bsnz24jx	181	21	.	.	NNP
cord-280549-bsnz24jx	181	22	,	,	,
cord-280549-bsnz24jx	181	23	2000	2000	CD
cord-280549-bsnz24jx	181	24	)	)	-RRB-
cord-280549-bsnz24jx	181	25	.	.	.
cord-280549-bsnz24jx	182	1	Growth	growth	NN
cord-280549-bsnz24jx	182	2	factors	factor	NNS
cord-280549-bsnz24jx	182	3	are	be	VBP
cord-280549-bsnz24jx	182	4	necessary	necessary	JJ
cord-280549-bsnz24jx	182	5	to	to	TO
cord-280549-bsnz24jx	182	6	drive	drive	VB
cord-280549-bsnz24jx	182	7	the	the	DT
cord-280549-bsnz24jx	182	8	cell	cell	NN
cord-280549-bsnz24jx	182	9	cycle	cycle	NN
cord-280549-bsnz24jx	182	10	machinery	machinery	NN
cord-280549-bsnz24jx	182	11	to	to	IN
cord-280549-bsnz24jx	182	12	the	the	DT
cord-280549-bsnz24jx	182	13	restriction	restriction	NN
cord-280549-bsnz24jx	182	14	point	point	NN
cord-280549-bsnz24jx	182	15	,	,	,
cord-280549-bsnz24jx	182	16	beyond	beyond	IN
cord-280549-bsnz24jx	182	17	which	which	WDT
cord-280549-bsnz24jx	182	18	commitment	commitment	NN
cord-280549-bsnz24jx	182	19	to	to	IN
cord-280549-bsnz24jx	182	20	cell	cell	NN
cord-280549-bsnz24jx	182	21	cycle	cycle	NN
cord-280549-bsnz24jx	182	22	progression	progression	NN
cord-280549-bsnz24jx	182	23	occurs	occur	VBZ
cord-280549-bsnz24jx	182	24	and	and	CC
cord-280549-bsnz24jx	182	25	the	the	DT
cord-280549-bsnz24jx	182	26	cell	cell	NN
cord-280549-bsnz24jx	182	27	enters	enter	VBZ
cord-280549-bsnz24jx	182	28	S	s	NN
cord-280549-bsnz24jx	182	29	phase	phase	NN
cord-280549-bsnz24jx	182	30	without	without	IN
cord-280549-bsnz24jx	182	31	requiring	require	VBG
cord-280549-bsnz24jx	182	32	extracellular	extracellular	JJ
cord-280549-bsnz24jx	182	33	mitogenic	mitogenic	JJ
cord-280549-bsnz24jx	182	34	signals	signal	NNS
cord-280549-bsnz24jx	182	35	.	.	.
cord-280549-bsnz24jx	183	1	Retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	183	2	(	(	-LRB-
cord-280549-bsnz24jx	183	3	Rb	Rb	NNP
cord-280549-bsnz24jx	183	4	)	)	-RRB-
cord-280549-bsnz24jx	183	5	protein	protein	NN
cord-280549-bsnz24jx	183	6	,	,	,
cord-280549-bsnz24jx	183	7	which	which	WDT
cord-280549-bsnz24jx	183	8	serves	serve	VBZ
cord-280549-bsnz24jx	183	9	as	as	IN
cord-280549-bsnz24jx	183	10	the	the	DT
cord-280549-bsnz24jx	183	11	guardian	guardian	NN
cord-280549-bsnz24jx	183	12	of	of	IN
cord-280549-bsnz24jx	183	13	restriction	restriction	NN
cord-280549-bsnz24jx	183	14	point	point	NN
cord-280549-bsnz24jx	183	15	,	,	,
cord-280549-bsnz24jx	183	16	represents	represent	VBZ
cord-280549-bsnz24jx	183	17	a	a	DT
cord-280549-bsnz24jx	183	18	non	non	JJ
cord-280549-bsnz24jx	183	19	-	-	JJ
cord-280549-bsnz24jx	183	20	redundant	redundant	JJ
cord-280549-bsnz24jx	183	21	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	183	22	that	that	WDT
cord-280549-bsnz24jx	183	23	can	can	MD
cord-280549-bsnz24jx	183	24	be	be	VB
cord-280549-bsnz24jx	183	25	targeted	target	VBN
cord-280549-bsnz24jx	183	26	by	by	IN
cord-280549-bsnz24jx	183	27	viruses	virus	NNS
cord-280549-bsnz24jx	183	28	to	to	TO
cord-280549-bsnz24jx	183	29	modulate	modulate	VB
cord-280549-bsnz24jx	183	30	host	host	NN
cord-280549-bsnz24jx	183	31	cell	cell	NN
cord-280549-bsnz24jx	183	32	cycle	cycle	NN
cord-280549-bsnz24jx	183	33	under	under	IN
cord-280549-bsnz24jx	183	34	growth	growth	NN
cord-280549-bsnz24jx	183	35	limiting	limit	VBG
cord-280549-bsnz24jx	183	36	conditions	condition	NNS
cord-280549-bsnz24jx	183	37	(	(	-LRB-
cord-280549-bsnz24jx	183	38	Blagosklonny	Blagosklonny	NNP
cord-280549-bsnz24jx	183	39	and	and	CC
cord-280549-bsnz24jx	183	40	Pardee	Pardee	NNP
cord-280549-bsnz24jx	183	41	,	,	,
cord-280549-bsnz24jx	183	42	2002	2002	CD
cord-280549-bsnz24jx	183	43	)	)	-RRB-
cord-280549-bsnz24jx	183	44	.	.	.
cord-280549-bsnz24jx	184	1	For	for	IN
cord-280549-bsnz24jx	184	2	example	example	NN
cord-280549-bsnz24jx	184	3	,	,	,
cord-280549-bsnz24jx	184	4	the	the	DT
cord-280549-bsnz24jx	184	5	adenovirus	adenovirus	NN
cord-280549-bsnz24jx	184	6	E1A	e1a	NN
cord-280549-bsnz24jx	184	7	not	not	RB
cord-280549-bsnz24jx	184	8	only	only	RB
cord-280549-bsnz24jx	184	9	associates	associate	NNS
cord-280549-bsnz24jx	184	10	with	with	IN
cord-280549-bsnz24jx	184	11	CKI	CKI	NNP
cord-280549-bsnz24jx	184	12	,	,	,
cord-280549-bsnz24jx	184	13	but	but	CC
cord-280549-bsnz24jx	184	14	also	also	RB
cord-280549-bsnz24jx	184	15	functions	function	VBZ
cord-280549-bsnz24jx	184	16	to	to	TO
cord-280549-bsnz24jx	184	17	dissociate	dissociate	VB
cord-280549-bsnz24jx	185	1	E2F	E2F	NNP
cord-280549-bsnz24jx	185	2	-	-	HYPH
cord-280549-bsnz24jx	185	3	Rb	Rb	NNP
cord-280549-bsnz24jx	185	4	/	/	SYM
cord-280549-bsnz24jx	185	5	p107	p107	NN
cord-280549-bsnz24jx	185	6	complexes	complex	NNS
cord-280549-bsnz24jx	185	7	owing	owe	VBG
cord-280549-bsnz24jx	185	8	to	to	IN
cord-280549-bsnz24jx	185	9	the	the	DT
cord-280549-bsnz24jx	185	10	interaction	interaction	NN
cord-280549-bsnz24jx	185	11	of	of	IN
cord-280549-bsnz24jx	185	12	its	-PRON-	PRP$
cord-280549-bsnz24jx	185	13	two	two	CD
cord-280549-bsnz24jx	185	14	conserved	conserved	JJ
cord-280549-bsnz24jx	185	15	regions	region	NNS
cord-280549-bsnz24jx	185	16	(	(	-LRB-
cord-280549-bsnz24jx	185	17	CRs	CRs	NNP
cord-280549-bsnz24jx	185	18	)	)	-RRB-
cord-280549-bsnz24jx	185	19	with	with	IN
cord-280549-bsnz24jx	185	20	Rb	Rb	NNP
cord-280549-bsnz24jx	185	21	(	(	-LRB-
cord-280549-bsnz24jx	185	22	Bagchi	Bagchi	NNP
cord-280549-bsnz24jx	185	23	et	et	NNP
cord-280549-bsnz24jx	185	24	al	al	NNP
cord-280549-bsnz24jx	185	25	.	.	NNP
cord-280549-bsnz24jx	185	26	,	,	,
cord-280549-bsnz24jx	185	27	1990	1990	CD
cord-280549-bsnz24jx	185	28	;	;	:
cord-280549-bsnz24jx	185	29	Raychaudhuri	Raychaudhuri	NNP
cord-280549-bsnz24jx	185	30	et	et	NNP
cord-280549-bsnz24jx	185	31	al	al	NNP
cord-280549-bsnz24jx	185	32	.	.	NNP
cord-280549-bsnz24jx	185	33	,	,	,
cord-280549-bsnz24jx	185	34	1991	1991	CD
cord-280549-bsnz24jx	185	35	)	)	-RRB-
cord-280549-bsnz24jx	185	36	.	.	.
cord-280549-bsnz24jx	186	1	It	-PRON-	PRP
cord-280549-bsnz24jx	186	2	was	be	VBD
cord-280549-bsnz24jx	186	3	proposed	propose	VBN
cord-280549-bsnz24jx	186	4	that	that	IN
cord-280549-bsnz24jx	186	5	the	the	DT
cord-280549-bsnz24jx	186	6	LXCXE	LXCXE	NNP
cord-280549-bsnz24jx	186	7	motif	motif	NN
cord-280549-bsnz24jx	186	8	-	-	HYPH
cord-280549-bsnz24jx	186	9	containing	contain	VBG
cord-280549-bsnz24jx	186	10	CR2	CR2	NNP
cord-280549-bsnz24jx	186	11	of	of	IN
cord-280549-bsnz24jx	186	12	E1A	E1A	NNP
cord-280549-bsnz24jx	186	13	mediates	mediate	VBZ
cord-280549-bsnz24jx	186	14	its	-PRON-	PRP$
cord-280549-bsnz24jx	186	15	initial	initial	JJ
cord-280549-bsnz24jx	186	16	binding	binding	NN
cord-280549-bsnz24jx	186	17	to	to	IN
cord-280549-bsnz24jx	186	18	Rb	Rb	NNP
cord-280549-bsnz24jx	186	19	,	,	,
cord-280549-bsnz24jx	186	20	allowing	allow	VBG
cord-280549-bsnz24jx	186	21	CR1	CR1	NNP
cord-280549-bsnz24jx	186	22	to	to	TO
cord-280549-bsnz24jx	186	23	block	block	VB
cord-280549-bsnz24jx	186	24	the	the	DT
cord-280549-bsnz24jx	186	25	sequences	sequence	NNS
cord-280549-bsnz24jx	186	26	on	on	IN
cord-280549-bsnz24jx	186	27	Rb	Rb	NNP
cord-280549-bsnz24jx	186	28	that	that	WDT
cord-280549-bsnz24jx	186	29	are	be	VBP
cord-280549-bsnz24jx	186	30	involved	involve	VBN
cord-280549-bsnz24jx	186	31	in	in	IN
cord-280549-bsnz24jx	186	32	E2F	e2f	NN
cord-280549-bsnz24jx	186	33	recognition	recognition	NN
cord-280549-bsnz24jx	186	34	by	by	IN
cord-280549-bsnz24jx	186	35	means	mean	NNS
cord-280549-bsnz24jx	186	36	of	of	IN
cord-280549-bsnz24jx	186	37	physical	physical	JJ
cord-280549-bsnz24jx	186	38	interaction	interaction	NN
cord-280549-bsnz24jx	186	39	(	(	-LRB-
cord-280549-bsnz24jx	186	40	Ikeda	Ikeda	NNP
cord-280549-bsnz24jx	186	41	and	and	CC
cord-280549-bsnz24jx	186	42	Nevins	Nevins	NNP
cord-280549-bsnz24jx	186	43	,	,	,
cord-280549-bsnz24jx	186	44	1993	1993	CD
cord-280549-bsnz24jx	186	45	)	)	-RRB-
cord-280549-bsnz24jx	186	46	.	.	.
cord-280549-bsnz24jx	187	1	The	the	DT
cord-280549-bsnz24jx	187	2	release	release	NN
cord-280549-bsnz24jx	187	3	of	of	IN
cord-280549-bsnz24jx	187	4	E2F	e2f	NN
cord-280549-bsnz24jx	187	5	,	,	,
cord-280549-bsnz24jx	187	6	therefore	therefore	RB
cord-280549-bsnz24jx	187	7	,	,	,
cord-280549-bsnz24jx	187	8	transcriptionally	transcriptionally	RB
cord-280549-bsnz24jx	187	9	activates	activate	VBZ
cord-280549-bsnz24jx	187	10	various	various	JJ
cord-280549-bsnz24jx	187	11	downstream	downstream	JJ
cord-280549-bsnz24jx	187	12	target	target	NN
cord-280549-bsnz24jx	187	13	genes	gene	NNS
cord-280549-bsnz24jx	187	14	that	that	WDT
cord-280549-bsnz24jx	187	15	are	be	VBP
cord-280549-bsnz24jx	187	16	required	require	VBN
cord-280549-bsnz24jx	187	17	for	for	IN
cord-280549-bsnz24jx	187	18	proliferation	proliferation	NN
cord-280549-bsnz24jx	187	19	and	and	CC
cord-280549-bsnz24jx	187	20	DNA	dna	NN
cord-280549-bsnz24jx	187	21	synthesis	synthesis	NN
cord-280549-bsnz24jx	187	22	,	,	,
cord-280549-bsnz24jx	187	23	including	include	VBG
cord-280549-bsnz24jx	187	24	c	c	NN
cord-280549-bsnz24jx	187	25	-	-	HYPH
cord-280549-bsnz24jx	187	26	myc	myc	NNP
cord-280549-bsnz24jx	187	27	and	and	CC
cord-280549-bsnz24jx	187	28	cyclin	cyclin	NN
cord-280549-bsnz24jx	187	29	E	E	NNP
cord-280549-bsnz24jx	187	30	(	(	-LRB-
cord-280549-bsnz24jx	187	31	Roussel	Roussel	NNP
cord-280549-bsnz24jx	187	32	et	et	NNP
cord-280549-bsnz24jx	187	33	al	al	NNP
cord-280549-bsnz24jx	187	34	.	.	NNP
cord-280549-bsnz24jx	187	35	,	,	,
cord-280549-bsnz24jx	187	36	1994	1994	CD
cord-280549-bsnz24jx	187	37	;	;	:
cord-280549-bsnz24jx	187	38	Ohtani	Ohtani	NNP
cord-280549-bsnz24jx	187	39	et	et	NNP
cord-280549-bsnz24jx	187	40	al	al	NNP
cord-280549-bsnz24jx	187	41	.	.	NNP
cord-280549-bsnz24jx	187	42	,	,	,
cord-280549-bsnz24jx	187	43	1995	1995	CD
cord-280549-bsnz24jx	187	44	)	)	-RRB-
cord-280549-bsnz24jx	187	45	.	.	.
cord-280549-bsnz24jx	188	1	Similarly	similarly	RB
cord-280549-bsnz24jx	188	2	,	,	,
cord-280549-bsnz24jx	188	3	HPV	HPV	NNP
cord-280549-bsnz24jx	188	4	E7	E7	NNP
cord-280549-bsnz24jx	188	5	possesses	possess	VBZ
cord-280549-bsnz24jx	188	6	two	two	CD
cord-280549-bsnz24jx	188	7	homology	homology	NN
cord-280549-bsnz24jx	188	8	regions	region	NNS
cord-280549-bsnz24jx	188	9	of	of	IN
cord-280549-bsnz24jx	188	10	CR1	CR1	NNP
cord-280549-bsnz24jx	188	11	and	and	CC
cord-280549-bsnz24jx	188	12	CR2	CR2	NNP
cord-280549-bsnz24jx	188	13	,	,	,
cord-280549-bsnz24jx	188	14	which	which	WDT
cord-280549-bsnz24jx	188	15	contribute	contribute	VBP
cord-280549-bsnz24jx	188	16	to	to	IN
cord-280549-bsnz24jx	188	17	the	the	DT
cord-280549-bsnz24jx	188	18	transformation	transformation	NN
cord-280549-bsnz24jx	188	19	properties	property	NNS
cord-280549-bsnz24jx	188	20	of	of	IN
cord-280549-bsnz24jx	188	21	E7	E7	NNP
cord-280549-bsnz24jx	188	22	through	through	IN
cord-280549-bsnz24jx	188	23	disruption	disruption	NN
cord-280549-bsnz24jx	188	24	of	of	IN
cord-280549-bsnz24jx	188	25	E2F	e2f	NN
cord-280549-bsnz24jx	188	26	-	-	HYPH
cord-280549-bsnz24jx	188	27	Rb	rb	NN
cord-280549-bsnz24jx	188	28	complexes	complex	NNS
cord-280549-bsnz24jx	189	1	(	(	-LRB-
cord-280549-bsnz24jx	189	2	Barbosa	Barbosa	NNP
cord-280549-bsnz24jx	189	3	et	et	NNP
cord-280549-bsnz24jx	189	4	al	al	NNP
cord-280549-bsnz24jx	189	5	.	.	NNP
cord-280549-bsnz24jx	189	6	,	,	,
cord-280549-bsnz24jx	189	7	1990	1990	CD
cord-280549-bsnz24jx	190	1	;	;	:
cord-280549-bsnz24jx	190	2	Huang	Huang	NNP
cord-280549-bsnz24jx	190	3	et	et	NNP
cord-280549-bsnz24jx	190	4	al	al	NNP
cord-280549-bsnz24jx	190	5	.	.	NNP
cord-280549-bsnz24jx	190	6	,	,	,
cord-280549-bsnz24jx	190	7	1993	1993	CD
cord-280549-bsnz24jx	190	8	;	;	:
cord-280549-bsnz24jx	190	9	Wu	Wu	NNP
cord-280549-bsnz24jx	190	10	et	et	NNP
cord-280549-bsnz24jx	190	11	al	al	NNP
cord-280549-bsnz24jx	190	12	.	.	NNP
cord-280549-bsnz24jx	190	13	,	,	,
cord-280549-bsnz24jx	190	14	1993	1993	CD
cord-280549-bsnz24jx	190	15	)	)	-RRB-
cord-280549-bsnz24jx	190	16	.	.	.
cord-280549-bsnz24jx	191	1	The	the	DT
cord-280549-bsnz24jx	191	2	association	association	NN
cord-280549-bsnz24jx	191	3	of	of	IN
cord-280549-bsnz24jx	191	4	the	the	DT
cord-280549-bsnz24jx	191	5	SV40	SV40	NNP
cord-280549-bsnz24jx	191	6	large	large	JJ
cord-280549-bsnz24jx	191	7	T	t	NN
cord-280549-bsnz24jx	191	8	-	-	HYPH
cord-280549-bsnz24jx	191	9	antigen	antigen	NN
cord-280549-bsnz24jx	191	10	(	(	-LRB-
cord-280549-bsnz24jx	191	11	L	l	NN
cord-280549-bsnz24jx	191	12	-	-	HYPH
cord-280549-bsnz24jx	191	13	Tag	Tag	NNP
cord-280549-bsnz24jx	191	14	)	)	-RRB-
cord-280549-bsnz24jx	191	15	,	,	,
cord-280549-bsnz24jx	191	16	which	which	WDT
cord-280549-bsnz24jx	191	17	is	be	VBZ
cord-280549-bsnz24jx	191	18	expressed	express	VBN
cord-280549-bsnz24jx	191	19	early	early	RB
cord-280549-bsnz24jx	191	20	during	during	IN
cord-280549-bsnz24jx	191	21	infection	infection	NN
cord-280549-bsnz24jx	191	22	and	and	CC
cord-280549-bsnz24jx	191	23	is	be	VBZ
cord-280549-bsnz24jx	191	24	essential	essential	JJ
cord-280549-bsnz24jx	191	25	for	for	IN
cord-280549-bsnz24jx	191	26	viral	viral	JJ
cord-280549-bsnz24jx	191	27	replication	replication	NN
cord-280549-bsnz24jx	191	28	,	,	,
cord-280549-bsnz24jx	191	29	with	with	IN
cord-280549-bsnz24jx	191	30	Rb	Rb	NNP
cord-280549-bsnz24jx	191	31	,	,	,
cord-280549-bsnz24jx	191	32	p107	p107	NN
cord-280549-bsnz24jx	191	33	,	,	,
cord-280549-bsnz24jx	191	34	and	and	CC
cord-280549-bsnz24jx	191	35	p130	p130	NNS
cord-280549-bsnz24jx	191	36	is	be	VBZ
cord-280549-bsnz24jx	191	37	attributed	attribute	VBN
cord-280549-bsnz24jx	191	38	to	to	IN
cord-280549-bsnz24jx	191	39	the	the	DT
cord-280549-bsnz24jx	191	40	viral	viral	JJ
cord-280549-bsnz24jx	191	41	LXCXE	lxcxe	NN
cord-280549-bsnz24jx	191	42	residues	residue	NNS
cord-280549-bsnz24jx	191	43	,	,	,
cord-280549-bsnz24jx	191	44	which	which	WDT
cord-280549-bsnz24jx	191	45	are	be	VBP
cord-280549-bsnz24jx	191	46	required	require	VBN
cord-280549-bsnz24jx	191	47	but	but	CC
cord-280549-bsnz24jx	191	48	not	not	RB
cord-280549-bsnz24jx	191	49	sufficient	sufficient	JJ
cord-280549-bsnz24jx	191	50	in	in	IN
cord-280549-bsnz24jx	191	51	L	l	NN
cord-280549-bsnz24jx	191	52	-	-	HYPH
cord-280549-bsnz24jx	191	53	Tag	tag	NN
cord-280549-bsnz24jx	191	54	-	-	HYPH
cord-280549-bsnz24jx	191	55	mediated	mediate	VBN
cord-280549-bsnz24jx	191	56	transformation	transformation	NN
cord-280549-bsnz24jx	191	57	(	(	-LRB-
cord-280549-bsnz24jx	191	58	DeCaprio	DeCaprio	NNP
cord-280549-bsnz24jx	191	59	et	et	NNP
cord-280549-bsnz24jx	191	60	al	al	NNP
cord-280549-bsnz24jx	191	61	.	.	NNP
cord-280549-bsnz24jx	191	62	,	,	,
cord-280549-bsnz24jx	191	63	1988	1988	CD
cord-280549-bsnz24jx	191	64	;	;	:
cord-280549-bsnz24jx	191	65	Chen	Chen	NNP
cord-280549-bsnz24jx	191	66	and	and	CC
cord-280549-bsnz24jx	191	67	Paucha	Paucha	NNP
cord-280549-bsnz24jx	191	68	,	,	,
cord-280549-bsnz24jx	191	69	1990	1990	CD
cord-280549-bsnz24jx	191	70	;	;	:
cord-280549-bsnz24jx	191	71	Thompson	Thompson	NNP
cord-280549-bsnz24jx	191	72	et	et	NNP
cord-280549-bsnz24jx	191	73	al	al	NNP
cord-280549-bsnz24jx	191	74	.	.	NNP
cord-280549-bsnz24jx	191	75	,	,	,
cord-280549-bsnz24jx	191	76	1990	1990	CD
cord-280549-bsnz24jx	191	77	;	;	:
cord-280549-bsnz24jx	191	78	Stubdal	Stubdal	NNP
cord-280549-bsnz24jx	191	79	et	et	NNP
cord-280549-bsnz24jx	191	80	al	al	NNP
cord-280549-bsnz24jx	191	81	.	.	NNP
cord-280549-bsnz24jx	191	82	,	,	,
cord-280549-bsnz24jx	191	83	1996	1996	CD
cord-280549-bsnz24jx	191	84	)	)	-RRB-
cord-280549-bsnz24jx	191	85	.	.	.
cord-280549-bsnz24jx	192	1	It	-PRON-	PRP
cord-280549-bsnz24jx	192	2	was	be	VBD
cord-280549-bsnz24jx	192	3	reported	report	VBN
cord-280549-bsnz24jx	192	4	that	that	IN
cord-280549-bsnz24jx	192	5	the	the	DT
cord-280549-bsnz24jx	192	6	N	n	CD
cord-280549-bsnz24jx	192	7	-	-	HYPH
cord-280549-bsnz24jx	192	8	terminus	terminus	NN
cord-280549-bsnz24jx	192	9	of	of	IN
cord-280549-bsnz24jx	192	10	L	l	NN
cord-280549-bsnz24jx	192	11	-	-	HYPH
cord-280549-bsnz24jx	192	12	Tag	Tag	NNP
cord-280549-bsnz24jx	192	13	,	,	,
cord-280549-bsnz24jx	192	14	which	which	WDT
cord-280549-bsnz24jx	192	15	shares	share	VBZ
cord-280549-bsnz24jx	192	16	sequence	sequence	NN
cord-280549-bsnz24jx	192	17	homology	homology	NN
cord-280549-bsnz24jx	192	18	with	with	IN
cord-280549-bsnz24jx	192	19	the	the	DT
cord-280549-bsnz24jx	192	20	J	J	NNP
cord-280549-bsnz24jx	192	21	domain	domain	NN
cord-280549-bsnz24jx	192	22	of	of	IN
cord-280549-bsnz24jx	192	23	heat	heat	NN
cord-280549-bsnz24jx	192	24	shock	shock	NN
cord-280549-bsnz24jx	192	25	protein	protein	NN
cord-280549-bsnz24jx	192	26	40	40	CD
cord-280549-bsnz24jx	192	27	(	(	-LRB-
cord-280549-bsnz24jx	192	28	HSP40	HSP40	NNP
cord-280549-bsnz24jx	192	29	)	)	-RRB-
cord-280549-bsnz24jx	192	30	,	,	,
cord-280549-bsnz24jx	192	31	is	be	VBZ
cord-280549-bsnz24jx	192	32	also	also	RB
cord-280549-bsnz24jx	192	33	required	require	VBN
cord-280549-bsnz24jx	192	34	to	to	TO
cord-280549-bsnz24jx	192	35	disrupt	disrupt	VB
cord-280549-bsnz24jx	192	36	the	the	DT
cord-280549-bsnz24jx	192	37	complex	complex	JJ
cord-280549-bsnz24jx	192	38	formation	formation	NN
cord-280549-bsnz24jx	192	39	between	between	IN
cord-280549-bsnz24jx	192	40	the	the	DT
cord-280549-bsnz24jx	192	41	three	three	CD
cord-280549-bsnz24jx	192	42	"	"	``
cord-280549-bsnz24jx	192	43	pocket	pocket	NN
cord-280549-bsnz24jx	192	44	"	"	''
cord-280549-bsnz24jx	192	45	proteins	protein	NNS
cord-280549-bsnz24jx	192	46	of	of	IN
cord-280549-bsnz24jx	192	47	the	the	DT
cord-280549-bsnz24jx	192	48	Rb	Rb	NNP
cord-280549-bsnz24jx	192	49	family	family	NN
cord-280549-bsnz24jx	192	50	with	with	IN
cord-280549-bsnz24jx	192	51	E2F	E2F	NNP
cord-280549-bsnz24jx	192	52	(	(	-LRB-
cord-280549-bsnz24jx	192	53	Zalvide	Zalvide	NNP
cord-280549-bsnz24jx	192	54	et	et	FW
cord-280549-bsnz24jx	192	55	al	al	NNP
cord-280549-bsnz24jx	192	56	.	.	NNP
cord-280549-bsnz24jx	192	57	,	,	,
cord-280549-bsnz24jx	192	58	1998	1998	CD
cord-280549-bsnz24jx	192	59	;	;	:
cord-280549-bsnz24jx	192	60	Sullivan	Sullivan	NNP
cord-280549-bsnz24jx	192	61	et	et	NNP
cord-280549-bsnz24jx	192	62	al	al	NNP
cord-280549-bsnz24jx	192	63	.	.	NNP
cord-280549-bsnz24jx	192	64	,	,	,
cord-280549-bsnz24jx	192	65	2000	2000	CD
cord-280549-bsnz24jx	192	66	)	)	-RRB-
cord-280549-bsnz24jx	192	67	.	.	.
cord-280549-bsnz24jx	193	1	The	the	DT
cord-280549-bsnz24jx	193	2	nuclear	nuclear	JJ
cord-280549-bsnz24jx	193	3	antigen	antigen	NN
cord-280549-bsnz24jx	193	4	5	5	CD
cord-280549-bsnz24jx	193	5	(	(	-LRB-
cord-280549-bsnz24jx	193	6	EBNA-5	EBNA-5	NNP
cord-280549-bsnz24jx	193	7	)	)	-RRB-
cord-280549-bsnz24jx	193	8	,	,	,
cord-280549-bsnz24jx	193	9	also	also	RB
cord-280549-bsnz24jx	193	10	known	know	VBN
cord-280549-bsnz24jx	193	11	as	as	IN
cord-280549-bsnz24jx	193	12	nuclear	nuclear	JJ
cord-280549-bsnz24jx	193	13	antigen	antigen	NN
cord-280549-bsnz24jx	193	14	leader	leader	NN
cord-280549-bsnz24jx	193	15	protein	protein	NN
cord-280549-bsnz24jx	193	16	(	(	-LRB-
cord-280549-bsnz24jx	193	17	EBNA	EBNA	NNP
cord-280549-bsnz24jx	193	18	-	-	HYPH
cord-280549-bsnz24jx	193	19	LP	LP	NNP
cord-280549-bsnz24jx	193	20	)	)	-RRB-
cord-280549-bsnz24jx	193	21	,	,	,
cord-280549-bsnz24jx	193	22	of	of	IN
cord-280549-bsnz24jx	193	23	Epstein	Epstein	NNP
cord-280549-bsnz24jx	193	24	-	-	HYPH
cord-280549-bsnz24jx	193	25	Barr	Barr	NNP
cord-280549-bsnz24jx	193	26	virus	virus	NN
cord-280549-bsnz24jx	193	27	(	(	-LRB-
cord-280549-bsnz24jx	193	28	EBV	EBV	NNP
cord-280549-bsnz24jx	193	29	)	)	-RRB-
cord-280549-bsnz24jx	194	1	FIGURE	figure	NN
cord-280549-bsnz24jx	195	1	1	1	LS
cord-280549-bsnz24jx	195	2	|	|	NNP
cord-280549-bsnz24jx	195	3	Cell	Cell	NNP
cord-280549-bsnz24jx	195	4	cycle	cycle	NN
cord-280549-bsnz24jx	195	5	subversion	subversion	NN
cord-280549-bsnz24jx	195	6	by	by	IN
cord-280549-bsnz24jx	195	7	protein	protein	NN
cord-280549-bsnz24jx	195	8	-	-	HYPH
cord-280549-bsnz24jx	195	9	protein	protein	NN
cord-280549-bsnz24jx	195	10	interaction	interaction	NN
cord-280549-bsnz24jx	195	11	.	.	.
cord-280549-bsnz24jx	196	1	(	(	-LRB-
cord-280549-bsnz24jx	196	2	A	a	NN
cord-280549-bsnz24jx	196	3	)	)	-RRB-
cord-280549-bsnz24jx	196	4	Binding	Binding	NNP
cord-280549-bsnz24jx	196	5	of	of	IN
cord-280549-bsnz24jx	196	6	Tax	tax	NN
cord-280549-bsnz24jx	196	7	and	and	CC
cord-280549-bsnz24jx	196	8	HBx	hbx	NN
cord-280549-bsnz24jx	196	9	proteins	protein	NNS
cord-280549-bsnz24jx	196	10	to	to	IN
cord-280549-bsnz24jx	196	11	cyclin	cyclin	VB
cord-280549-bsnz24jx	197	1	and/or	and/or	CC
cord-280549-bsnz24jx	198	1	CDK	CDK	NNP
cord-280549-bsnz24jx	198	2	promotes	promote	VBZ
cord-280549-bsnz24jx	198	3	cell	cell	NN
cord-280549-bsnz24jx	198	4	cycle	cycle	NN
cord-280549-bsnz24jx	198	5	progression	progression	NN
cord-280549-bsnz24jx	198	6	either	either	CC
cord-280549-bsnz24jx	198	7	by	by	IN
cord-280549-bsnz24jx	198	8	enhancing	enhance	VBG
cord-280549-bsnz24jx	198	9	kinase	kinase	NN
cord-280549-bsnz24jx	198	10	activity	activity	NN
cord-280549-bsnz24jx	199	1	and/or	and/or	CC
cord-280549-bsnz24jx	199	2	weakening	weaken	VBG
cord-280549-bsnz24jx	199	3	the	the	DT
cord-280549-bsnz24jx	199	4	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	199	5	effect	effect	NN
cord-280549-bsnz24jx	199	6	of	of	IN
cord-280549-bsnz24jx	199	7	CKI	CKI	NNP
cord-280549-bsnz24jx	199	8	(	(	-LRB-
cord-280549-bsnz24jx	199	9	Benn	Benn	NNP
cord-280549-bsnz24jx	199	10	and	and	CC
cord-280549-bsnz24jx	199	11	Schneider	Schneider	NNP
cord-280549-bsnz24jx	199	12	,	,	,
cord-280549-bsnz24jx	199	13	1995	1995	CD
cord-280549-bsnz24jx	199	14	;	;	:
cord-280549-bsnz24jx	200	1	Neuveut	Neuveut	NNP
cord-280549-bsnz24jx	200	2	et	et	NNP
cord-280549-bsnz24jx	200	3	al	al	NNP
cord-280549-bsnz24jx	200	4	.	.	NNP
cord-280549-bsnz24jx	200	5	,	,	,
cord-280549-bsnz24jx	200	6	1998	1998	CD
cord-280549-bsnz24jx	200	7	;	;	:
cord-280549-bsnz24jx	200	8	Haller	Haller	NNP
cord-280549-bsnz24jx	200	9	et	et	NNP
cord-280549-bsnz24jx	200	10	al	al	NNP
cord-280549-bsnz24jx	200	11	.	.	NNP
cord-280549-bsnz24jx	200	12	,	,	,
cord-280549-bsnz24jx	200	13	2002	2002	CD
cord-280549-bsnz24jx	200	14	)	)	-RRB-
cord-280549-bsnz24jx	200	15	.	.	.
cord-280549-bsnz24jx	201	1	Direct	direct	JJ
cord-280549-bsnz24jx	201	2	binding	binding	NN
cord-280549-bsnz24jx	201	3	of	of	IN
cord-280549-bsnz24jx	201	4	either	either	DT
cord-280549-bsnz24jx	201	5	K	K	NNP
cord-280549-bsnz24jx	201	6	-	-	HYPH
cord-280549-bsnz24jx	201	7	bZIP	bzip	JJ
cord-280549-bsnz24jx	201	8	protein	protein	NN
cord-280549-bsnz24jx	201	9	of	of	IN
cord-280549-bsnz24jx	201	10	KSHV	KSHV	NNP
cord-280549-bsnz24jx	201	11	or	or	CC
cord-280549-bsnz24jx	201	12	p30	p30	NN
cord-280549-bsnz24jx	201	13	of	of	IN
cord-280549-bsnz24jx	201	14	HTLV-1	HTLV-1	NNP
cord-280549-bsnz24jx	201	15	to	to	IN
cord-280549-bsnz24jx	201	16	both	both	DT
cord-280549-bsnz24jx	201	17	CDK2	CDK2	NNP
cord-280549-bsnz24jx	201	18	and	and	CC
cord-280549-bsnz24jx	201	19	cyclin	cyclin	NN
cord-280549-bsnz24jx	201	20	E	e	NN
cord-280549-bsnz24jx	201	21	leads	lead	VBZ
cord-280549-bsnz24jx	201	22	to	to	IN
cord-280549-bsnz24jx	201	23	extended	extend	VBN
cord-280549-bsnz24jx	201	24	G1	G1	NNP
cord-280549-bsnz24jx	201	25	duration	duration	NN
cord-280549-bsnz24jx	201	26	or	or	CC
cord-280549-bsnz24jx	201	27	block	block	NN
cord-280549-bsnz24jx	201	28	of	of	IN
cord-280549-bsnz24jx	201	29	G1	G1	NNP
cord-280549-bsnz24jx	201	30	/	/	SYM
cord-280549-bsnz24jx	201	31	S	S	NNP
cord-280549-bsnz24jx	201	32	transition	transition	NN
cord-280549-bsnz24jx	202	1	(	(	-LRB-
cord-280549-bsnz24jx	202	2	Izumiya	Izumiya	NNP
cord-280549-bsnz24jx	202	3	et	et	NNP
cord-280549-bsnz24jx	202	4	al	al	NNP
cord-280549-bsnz24jx	202	5	.	.	NNP
cord-280549-bsnz24jx	202	6	,	,	,
cord-280549-bsnz24jx	202	7	2003	2003	CD
cord-280549-bsnz24jx	203	1	;	;	:
cord-280549-bsnz24jx	203	2	Baydoun	Baydoun	NNP
cord-280549-bsnz24jx	203	3	et	et	NNP
cord-280549-bsnz24jx	203	4	al	al	NNP
cord-280549-bsnz24jx	203	5	.	.	NNP
cord-280549-bsnz24jx	203	6	,	,	,
cord-280549-bsnz24jx	203	7	2010	2010	CD
cord-280549-bsnz24jx	203	8	)	)	-RRB-
cord-280549-bsnz24jx	203	9	.	.	.
cord-280549-bsnz24jx	204	1	Similarly	similarly	RB
cord-280549-bsnz24jx	204	2	,	,	,
cord-280549-bsnz24jx	204	3	direct	direct	JJ
cord-280549-bsnz24jx	204	4	interaction	interaction	NN
cord-280549-bsnz24jx	204	5	of	of	IN
cord-280549-bsnz24jx	204	6	M2	M2	NNP
cord-280549-bsnz24jx	204	7	of	of	IN
cord-280549-bsnz24jx	204	8	influenza	influenza	NN
cord-280549-bsnz24jx	204	9	A	a	DT
cord-280549-bsnz24jx	204	10	virus	virus	NN
cord-280549-bsnz24jx	204	11	with	with	IN
cord-280549-bsnz24jx	204	12	cyclin	cyclin	NN
cord-280549-bsnz24jx	204	13	D3	D3	NNP
cord-280549-bsnz24jx	204	14	arrested	arrest	VBN
cord-280549-bsnz24jx	204	15	cell	cell	NN
cord-280549-bsnz24jx	204	16	cycle	cycle	NN
cord-280549-bsnz24jx	204	17	in	in	IN
cord-280549-bsnz24jx	204	18	G0	G0	NNP
cord-280549-bsnz24jx	204	19	/	/	SYM
cord-280549-bsnz24jx	204	20	G1	g1	NN
cord-280549-bsnz24jx	204	21	phase	phase	NN
cord-280549-bsnz24jx	204	22	(	(	-LRB-
cord-280549-bsnz24jx	204	23	Fan	Fan	NNP
cord-280549-bsnz24jx	204	24	et	et	NNP
cord-280549-bsnz24jx	204	25	al	al	NNP
cord-280549-bsnz24jx	204	26	.	.	NNP
cord-280549-bsnz24jx	204	27	,	,	,
cord-280549-bsnz24jx	204	28	2017	2017	CD
cord-280549-bsnz24jx	204	29	)	)	-RRB-
cord-280549-bsnz24jx	204	30	.	.	.
cord-280549-bsnz24jx	205	1	(	(	-LRB-
cord-280549-bsnz24jx	205	2	Bi	Bi	NNP
cord-280549-bsnz24jx	205	3	)	)	-RRB-
cord-280549-bsnz24jx	205	4	Binding	binding	NN
cord-280549-bsnz24jx	205	5	of	of	IN
cord-280549-bsnz24jx	205	6	E1A	e1a	NN
cord-280549-bsnz24jx	205	7	to	to	IN
cord-280549-bsnz24jx	205	8	p27	p27	NN
cord-280549-bsnz24jx	205	9	KIP1	KIP1	NNP
cord-280549-bsnz24jx	205	10	blocks	block	VBZ
cord-280549-bsnz24jx	205	11	its	-PRON-	PRP$
cord-280549-bsnz24jx	205	12	inhibition	inhibition	NN
cord-280549-bsnz24jx	205	13	on	on	IN
cord-280549-bsnz24jx	205	14	CDK2	CDK2	NNP
cord-280549-bsnz24jx	205	15	kinase	kinase	NN
cord-280549-bsnz24jx	205	16	activity	activity	NN
cord-280549-bsnz24jx	205	17	,	,	,
cord-280549-bsnz24jx	205	18	overcoming	overcome	VBG
cord-280549-bsnz24jx	205	19	cell	cell	NN
cord-280549-bsnz24jx	205	20	cycle	cycle	NN
cord-280549-bsnz24jx	205	21	arrest	arrest	NN
cord-280549-bsnz24jx	205	22	in	in	IN
cord-280549-bsnz24jx	205	23	late	late	JJ
cord-280549-bsnz24jx	205	24	G1	G1	NNP
cord-280549-bsnz24jx	205	25	phase	phase	NN
cord-280549-bsnz24jx	205	26	(	(	-LRB-
cord-280549-bsnz24jx	206	1	Mal	Mal	NNP
cord-280549-bsnz24jx	206	2	et	et	FW
cord-280549-bsnz24jx	206	3	al	al	NNP
cord-280549-bsnz24jx	206	4	.	.	.
cord-280549-bsnz24jx	207	1	,	,	,
cord-280549-bsnz24jx	207	2	1996	1996	CD
cord-280549-bsnz24jx	207	3	)	)	-RRB-
cord-280549-bsnz24jx	207	4	.	.	.
cord-280549-bsnz24jx	208	1	In	in	IN
cord-280549-bsnz24jx	208	2	addition	addition	NN
cord-280549-bsnz24jx	208	3	to	to	IN
cord-280549-bsnz24jx	208	4	its	-PRON-	PRP$
cord-280549-bsnz24jx	208	5	association	association	NN
cord-280549-bsnz24jx	208	6	with	with	IN
cord-280549-bsnz24jx	208	7	cyclins	cyclin	NNS
cord-280549-bsnz24jx	208	8	,	,	,
cord-280549-bsnz24jx	208	9	HTLV-1	HTLV-1	NNP
cord-280549-bsnz24jx	208	10	Tax	Tax	NNP
cord-280549-bsnz24jx	208	11	is	be	VBZ
cord-280549-bsnz24jx	208	12	also	also	RB
cord-280549-bsnz24jx	208	13	able	able	JJ
cord-280549-bsnz24jx	208	14	to	to	TO
cord-280549-bsnz24jx	208	15	interact	interact	VB
cord-280549-bsnz24jx	208	16	with	with	IN
cord-280549-bsnz24jx	208	17	p16	p16	NN
cord-280549-bsnz24jx	208	18	INK4A	INK4A	NNS
cord-280549-bsnz24jx	208	19	and	and	CC
cord-280549-bsnz24jx	208	20	relieve	relieve	VB
cord-280549-bsnz24jx	208	21	p16	p16	CD
cord-280549-bsnz24jx	208	22	INK4A	INK4A	NNS
cord-280549-bsnz24jx	208	23	-imposed	-imposed	JJ
cord-280549-bsnz24jx	208	24	blockage	blockage	NN
cord-280549-bsnz24jx	208	25	of	of	IN
cord-280549-bsnz24jx	208	26	G1	G1	NNP
cord-280549-bsnz24jx	208	27	to	to	IN
cord-280549-bsnz24jx	208	28	S	s	NN
cord-280549-bsnz24jx	208	29	transition	transition	NN
cord-280549-bsnz24jx	209	1	(	(	-LRB-
cord-280549-bsnz24jx	209	2	Suzuki	Suzuki	NNP
cord-280549-bsnz24jx	209	3	et	et	FW
cord-280549-bsnz24jx	209	4	al	al	NNP
cord-280549-bsnz24jx	209	5	.	.	.
cord-280549-bsnz24jx	210	1	,	,	,
cord-280549-bsnz24jx	210	2	1996	1996	CD
cord-280549-bsnz24jx	210	3	;	;	:
cord-280549-bsnz24jx	210	4	Low	Low	NNP
cord-280549-bsnz24jx	210	5	et	et	FW
cord-280549-bsnz24jx	210	6	al	al	NNP
cord-280549-bsnz24jx	210	7	.	.	NNP
cord-280549-bsnz24jx	210	8	,	,	,
cord-280549-bsnz24jx	210	9	1997	1997	CD
cord-280549-bsnz24jx	210	10	)	)	-RRB-
cord-280549-bsnz24jx	210	11	.	.	.
cord-280549-bsnz24jx	211	1	(	(	-LRB-
cord-280549-bsnz24jx	211	2	Bii	Bii	NNP
cord-280549-bsnz24jx	211	3	)	)	-RRB-
cord-280549-bsnz24jx	211	4	p21	p21	NN
cord-280549-bsnz24jx	211	5	WAF1	WAF1	NNP
cord-280549-bsnz24jx	211	6	/	/	SYM
cord-280549-bsnz24jx	211	7	CIP1	CIP1	NNP
cord-280549-bsnz24jx	211	8	can	can	MD
cord-280549-bsnz24jx	211	9	block	block	VB
cord-280549-bsnz24jx	211	10	the	the	DT
cord-280549-bsnz24jx	211	11	interaction	interaction	NN
cord-280549-bsnz24jx	211	12	between	between	IN
cord-280549-bsnz24jx	211	13	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	211	14	and	and	CC
cord-280549-bsnz24jx	211	15	proliferating	proliferate	VBG
cord-280549-bsnz24jx	211	16	cell	cell	NN
cord-280549-bsnz24jx	211	17	nuclear	nuclear	JJ
cord-280549-bsnz24jx	211	18	antigen	antigen	NN
cord-280549-bsnz24jx	211	19	(	(	-LRB-
cord-280549-bsnz24jx	211	20	PCNA	PCNA	NNP
cord-280549-bsnz24jx	211	21	)	)	-RRB-
cord-280549-bsnz24jx	211	22	by	by	IN
cord-280549-bsnz24jx	211	23	competing	compete	VBG
cord-280549-bsnz24jx	211	24	with	with	IN
cord-280549-bsnz24jx	211	25	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	211	26	for	for	IN
cord-280549-bsnz24jx	211	27	PCNA	PCNA	NNS
cord-280549-bsnz24jx	211	28	binding	bind	VBG
cord-280549-bsnz24jx	211	29	.	.	.
cord-280549-bsnz24jx	212	1	This	this	DT
cord-280549-bsnz24jx	212	2	observation	observation	NN
cord-280549-bsnz24jx	212	3	points	point	VBZ
cord-280549-bsnz24jx	212	4	to	to	IN
cord-280549-bsnz24jx	212	5	a	a	DT
cord-280549-bsnz24jx	212	6	role	role	NN
cord-280549-bsnz24jx	212	7	of	of	IN
cord-280549-bsnz24jx	212	8	p21	p21	NN
cord-280549-bsnz24jx	212	9	WAF1	WAF1	NNP
cord-280549-bsnz24jx	212	10	/	/	SYM
cord-280549-bsnz24jx	212	11	CIP1	CIP1	NNP
cord-280549-bsnz24jx	212	12	in	in	IN
cord-280549-bsnz24jx	212	13	G2	G2	NNP
cord-280549-bsnz24jx	212	14	cell	cell	NN
cord-280549-bsnz24jx	212	15	cycle	cycle	NN
cord-280549-bsnz24jx	212	16	arrest	arrest	NN
cord-280549-bsnz24jx	212	17	upon	upon	IN
cord-280549-bsnz24jx	212	18	DNA	dna	NN
cord-280549-bsnz24jx	212	19	damage	damage	NN
cord-280549-bsnz24jx	213	1	(	(	-LRB-
cord-280549-bsnz24jx	213	2	Ando	Ando	NNP
cord-280549-bsnz24jx	213	3	et	et	NNP
cord-280549-bsnz24jx	213	4	al	al	NNP
cord-280549-bsnz24jx	213	5	.	.	NNP
cord-280549-bsnz24jx	213	6	,	,	,
cord-280549-bsnz24jx	213	7	2001	2001	CD
cord-280549-bsnz24jx	213	8	)	)	-RRB-
cord-280549-bsnz24jx	213	9	.	.	.
cord-280549-bsnz24jx	214	1	Competition	competition	NN
cord-280549-bsnz24jx	214	2	between	between	IN
cord-280549-bsnz24jx	214	3	core	core	NN
cord-280549-bsnz24jx	214	4	protein	protein	NN
cord-280549-bsnz24jx	214	5	of	of	IN
cord-280549-bsnz24jx	214	6	hepatitis	hepatitis	NNP
cord-280549-bsnz24jx	214	7	C	C	NNP
cord-280549-bsnz24jx	214	8	virus	virus	NN
cord-280549-bsnz24jx	214	9	and	and	CC
cord-280549-bsnz24jx	214	10	PCNA	PCNA	NNP
cord-280549-bsnz24jx	214	11	for	for	IN
cord-280549-bsnz24jx	214	12	the	the	DT
cord-280549-bsnz24jx	214	13	association	association	NN
cord-280549-bsnz24jx	214	14	with	with	IN
cord-280549-bsnz24jx	214	15	p21	p21	NNP
cord-280549-bsnz24jx	214	16	WAF1	WAF1	NNP
cord-280549-bsnz24jx	214	17	/	/	SYM
cord-280549-bsnz24jx	214	18	CIP1	CIP1	NNP
cord-280549-bsnz24jx	214	19	may	may	MD
cord-280549-bsnz24jx	214	20	disrupt	disrupt	VB
cord-280549-bsnz24jx	214	21	PCNA	PCNA	NNP
cord-280549-bsnz24jx	214	22	-	-	HYPH
cord-280549-bsnz24jx	214	23	p21	p21	NN
cord-280549-bsnz24jx	214	24	WAF1	WAF1	NNP
cord-280549-bsnz24jx	214	25	/	/	SYM
cord-280549-bsnz24jx	214	26	CIP1	CIP1	NNP
cord-280549-bsnz24jx	214	27	binding	binding	NN
cord-280549-bsnz24jx	214	28	,	,	,
cord-280549-bsnz24jx	214	29	leading	lead	VBG
cord-280549-bsnz24jx	214	30	to	to	IN
cord-280549-bsnz24jx	214	31	impaired	impaired	JJ
cord-280549-bsnz24jx	214	32	cell	cell	NN
cord-280549-bsnz24jx	214	33	cycle	cycle	NN
cord-280549-bsnz24jx	214	34	arrest	arrest	NN
cord-280549-bsnz24jx	214	35	in	in	IN
cord-280549-bsnz24jx	214	36	G2	G2	NNP
cord-280549-bsnz24jx	214	37	and	and	CC
cord-280549-bsnz24jx	214	38	DNA	dna	NN
cord-280549-bsnz24jx	214	39	repair	repair	NN
cord-280549-bsnz24jx	214	40	in	in	IN
cord-280549-bsnz24jx	214	41	response	response	NN
cord-280549-bsnz24jx	214	42	to	to	IN
cord-280549-bsnz24jx	214	43	damage	damage	NN
cord-280549-bsnz24jx	214	44	signals	signal	NNS
cord-280549-bsnz24jx	214	45	.	.	.
cord-280549-bsnz24jx	215	1	(	(	-LRB-
cord-280549-bsnz24jx	215	2	C	C	NNP
cord-280549-bsnz24jx	215	3	)	)	-RRB-
cord-280549-bsnz24jx	216	1	E1A	E1A	NNP
cord-280549-bsnz24jx	216	2	protein	protein	NN
cord-280549-bsnz24jx	216	3	of	of	IN
cord-280549-bsnz24jx	216	4	adenovirus	adenovirus	NN
cord-280549-bsnz24jx	216	5	functions	function	NNS
cord-280549-bsnz24jx	216	6	to	to	TO
cord-280549-bsnz24jx	216	7	dissociate	dissociate	VB
cord-280549-bsnz24jx	216	8	E2F	e2f	NN
cord-280549-bsnz24jx	216	9	-	-	HYPH
cord-280549-bsnz24jx	216	10	Rb	Rb	NNP
cord-280549-bsnz24jx	216	11	/	/	SYM
cord-280549-bsnz24jx	216	12	p107	p107	NN
cord-280549-bsnz24jx	216	13	complexes	complex	NNS
cord-280549-bsnz24jx	217	1	owing	owe	VBG
cord-280549-bsnz24jx	217	2	to	to	IN
cord-280549-bsnz24jx	217	3	the	the	DT
cord-280549-bsnz24jx	217	4	interaction	interaction	NN
cord-280549-bsnz24jx	217	5	of	of	IN
cord-280549-bsnz24jx	217	6	its	-PRON-	PRP$
cord-280549-bsnz24jx	217	7	two	two	CD
cord-280549-bsnz24jx	217	8	conserved	conserved	JJ
cord-280549-bsnz24jx	217	9	regions	region	NNS
cord-280549-bsnz24jx	217	10	with	with	IN
cord-280549-bsnz24jx	217	11	Rb	Rb	NNP
cord-280549-bsnz24jx	217	12	(	(	-LRB-
cord-280549-bsnz24jx	217	13	Bagchi	Bagchi	NNP
cord-280549-bsnz24jx	217	14	et	et	NNP
cord-280549-bsnz24jx	217	15	al	al	NNP
cord-280549-bsnz24jx	217	16	.	.	NNP
cord-280549-bsnz24jx	217	17	,	,	,
cord-280549-bsnz24jx	217	18	1990	1990	CD
cord-280549-bsnz24jx	217	19	;	;	:
cord-280549-bsnz24jx	217	20	Raychaudhuri	Raychaudhuri	NNP
cord-280549-bsnz24jx	217	21	et	et	NNP
cord-280549-bsnz24jx	217	22	al	al	NNP
cord-280549-bsnz24jx	217	23	.	.	NNP
cord-280549-bsnz24jx	217	24	,	,	,
cord-280549-bsnz24jx	217	25	1991	1991	CD
cord-280549-bsnz24jx	217	26	)	)	-RRB-
cord-280549-bsnz24jx	217	27	.	.	.
cord-280549-bsnz24jx	218	1	The	the	DT
cord-280549-bsnz24jx	218	2	release	release	NN
cord-280549-bsnz24jx	218	3	of	of	IN
cord-280549-bsnz24jx	218	4	E2F	e2f	NN
cord-280549-bsnz24jx	218	5	,	,	,
cord-280549-bsnz24jx	218	6	therefore	therefore	RB
cord-280549-bsnz24jx	218	7	,	,	,
cord-280549-bsnz24jx	218	8	transcriptionally	transcriptionally	RB
cord-280549-bsnz24jx	218	9	activates	activate	VBZ
cord-280549-bsnz24jx	218	10	various	various	JJ
cord-280549-bsnz24jx	218	11	downstream	downstream	JJ
cord-280549-bsnz24jx	218	12	target	target	NN
cord-280549-bsnz24jx	218	13	genes	gene	NNS
cord-280549-bsnz24jx	218	14	that	that	WDT
cord-280549-bsnz24jx	218	15	are	be	VBP
cord-280549-bsnz24jx	218	16	required	require	VBN
cord-280549-bsnz24jx	218	17	for	for	IN
cord-280549-bsnz24jx	218	18	proliferation	proliferation	NN
cord-280549-bsnz24jx	218	19	and	and	CC
cord-280549-bsnz24jx	218	20	DNA	dna	NN
cord-280549-bsnz24jx	218	21	synthesis	synthesis	NN
cord-280549-bsnz24jx	218	22	,	,	,
cord-280549-bsnz24jx	218	23	including	include	VBG
cord-280549-bsnz24jx	218	24	c	c	NN
cord-280549-bsnz24jx	218	25	-	-	HYPH
cord-280549-bsnz24jx	218	26	myc	myc	NNP
cord-280549-bsnz24jx	218	27	and	and	CC
cord-280549-bsnz24jx	218	28	cyclin	cyclin	NN
cord-280549-bsnz24jx	218	29	E	E	NNP
cord-280549-bsnz24jx	218	30	(	(	-LRB-
cord-280549-bsnz24jx	218	31	Roussel	Roussel	NNP
cord-280549-bsnz24jx	218	32	et	et	NNP
cord-280549-bsnz24jx	218	33	al	al	NNP
cord-280549-bsnz24jx	218	34	.	.	NNP
cord-280549-bsnz24jx	218	35	,	,	,
cord-280549-bsnz24jx	218	36	1994	1994	CD
cord-280549-bsnz24jx	218	37	;	;	:
cord-280549-bsnz24jx	218	38	Ohtani	Ohtani	NNP
cord-280549-bsnz24jx	218	39	et	et	NNP
cord-280549-bsnz24jx	218	40	al	al	NNP
cord-280549-bsnz24jx	218	41	.	.	NNP
cord-280549-bsnz24jx	218	42	,	,	,
cord-280549-bsnz24jx	218	43	1995	1995	CD
cord-280549-bsnz24jx	218	44	)	)	-RRB-
cord-280549-bsnz24jx	218	45	.	.	.
cord-280549-bsnz24jx	219	1	Frontiers	frontier	NNS
cord-280549-bsnz24jx	219	2	in	in	IN
cord-280549-bsnz24jx	219	3	Cellular	Cellular	NNP
cord-280549-bsnz24jx	219	4	and	and	CC
cord-280549-bsnz24jx	219	5	Infection	Infection	NNP
cord-280549-bsnz24jx	219	6	Microbiology	Microbiology	NNP
cord-280549-bsnz24jx	219	7	|	|	NNP
cord-280549-bsnz24jx	219	8	www.frontiersin.org	www.frontiersin.org	NN
cord-280549-bsnz24jx	219	9	cooperates	cooperate	VBZ
cord-280549-bsnz24jx	219	10	with	with	IN
cord-280549-bsnz24jx	219	11	its	-PRON-	PRP$
cord-280549-bsnz24jx	219	12	nuclear	nuclear	JJ
cord-280549-bsnz24jx	219	13	antigen	antigen	NN
cord-280549-bsnz24jx	219	14	2	2	CD
cord-280549-bsnz24jx	219	15	(	(	-LRB-
cord-280549-bsnz24jx	219	16	EBNA-2	EBNA-2	NNP
cord-280549-bsnz24jx	219	17	)	)	-RRB-
cord-280549-bsnz24jx	219	18	to	to	TO
cord-280549-bsnz24jx	219	19	prompt	prompt	VB
cord-280549-bsnz24jx	219	20	G0	g0	NN
cord-280549-bsnz24jx	219	21	to	to	IN
cord-280549-bsnz24jx	219	22	G1	g1	NN
cord-280549-bsnz24jx	219	23	progression	progression	NN
cord-280549-bsnz24jx	219	24	during	during	IN
cord-280549-bsnz24jx	219	25	the	the	DT
cord-280549-bsnz24jx	219	26	immortalization	immortalization	NN
cord-280549-bsnz24jx	219	27	of	of	IN
cord-280549-bsnz24jx	219	28	virus	virus	NN
cord-280549-bsnz24jx	219	29	-	-	HYPH
cord-280549-bsnz24jx	219	30	infected	infect	VBN
cord-280549-bsnz24jx	219	31	cells	cell	NNS
cord-280549-bsnz24jx	220	1	(	(	-LRB-
cord-280549-bsnz24jx	220	2	Sinclair	Sinclair	NNP
cord-280549-bsnz24jx	220	3	et	et	NNP
cord-280549-bsnz24jx	220	4	al	al	NNP
cord-280549-bsnz24jx	220	5	.	.	NNP
cord-280549-bsnz24jx	220	6	,	,	,
cord-280549-bsnz24jx	220	7	1994	1994	CD
cord-280549-bsnz24jx	220	8	)	)	-RRB-
cord-280549-bsnz24jx	220	9	.	.	.
cord-280549-bsnz24jx	221	1	Unlike	unlike	IN
cord-280549-bsnz24jx	221	2	the	the	DT
cord-280549-bsnz24jx	221	3	E1A	e1a	NN
cord-280549-bsnz24jx	221	4	of	of	IN
cord-280549-bsnz24jx	221	5	adenovirus	adenovirus	NN
cord-280549-bsnz24jx	221	6	,	,	,
cord-280549-bsnz24jx	221	7	E7	E7	NNP
cord-280549-bsnz24jx	221	8	of	of	IN
cord-280549-bsnz24jx	221	9	HPV	HPV	NNP
cord-280549-bsnz24jx	221	10	,	,	,
cord-280549-bsnz24jx	221	11	and	and	CC
cord-280549-bsnz24jx	221	12	L	l	NN
cord-280549-bsnz24jx	221	13	-	-	HYPH
cord-280549-bsnz24jx	221	14	Tag	Tag	NNP
cord-280549-bsnz24jx	221	15	of	of	IN
cord-280549-bsnz24jx	221	16	SV40	SV40	NNP
cord-280549-bsnz24jx	221	17	,	,	,
cord-280549-bsnz24jx	221	18	EBNA-5	EBNA-5	NNP
cord-280549-bsnz24jx	221	19	localizes	localize	VBZ
cord-280549-bsnz24jx	221	20	with	with	IN
cord-280549-bsnz24jx	221	21	and	and	CC
cord-280549-bsnz24jx	221	22	binds	bind	VBZ
cord-280549-bsnz24jx	221	23	to	to	IN
cord-280549-bsnz24jx	221	24	Rb	Rb	NNP
cord-280549-bsnz24jx	221	25	without	without	IN
cord-280549-bsnz24jx	221	26	possessing	possess	VBG
cord-280549-bsnz24jx	221	27	a	a	DT
cord-280549-bsnz24jx	221	28	LXCXE	LXCXE	NNP
cord-280549-bsnz24jx	221	29	motif	motif	NN
cord-280549-bsnz24jx	221	30	.	.	.
cord-280549-bsnz24jx	222	1	Although	although	IN
cord-280549-bsnz24jx	222	2	study	study	NN
cord-280549-bsnz24jx	222	3	revealed	reveal	VBD
cord-280549-bsnz24jx	222	4	that	that	IN
cord-280549-bsnz24jx	222	5	the	the	DT
cord-280549-bsnz24jx	222	6	carboxy	carboxy	JJ
cord-280549-bsnz24jx	222	7	-	-	HYPH
cord-280549-bsnz24jx	222	8	terminal	terminal	NN
cord-280549-bsnz24jx	222	9	45	45	CD
cord-280549-bsnz24jx	222	10	amino	amino	JJ
cord-280549-bsnz24jx	222	11	acids	acid	NNS
cord-280549-bsnz24jx	222	12	of	of	IN
cord-280549-bsnz24jx	222	13	EBNA-5	EBNA-5	NNS
cord-280549-bsnz24jx	222	14	are	be	VBP
cord-280549-bsnz24jx	222	15	crucial	crucial	JJ
cord-280549-bsnz24jx	222	16	for	for	IN
cord-280549-bsnz24jx	222	17	B	b	NN
cord-280549-bsnz24jx	222	18	cell	cell	NN
cord-280549-bsnz24jx	222	19	transformation	transformation	NN
cord-280549-bsnz24jx	222	20	(	(	-LRB-
cord-280549-bsnz24jx	222	21	Jiang	Jiang	NNP
cord-280549-bsnz24jx	222	22	et	et	FW
cord-280549-bsnz24jx	222	23	al	al	NNP
cord-280549-bsnz24jx	222	24	.	.	NNP
cord-280549-bsnz24jx	222	25	,	,	,
cord-280549-bsnz24jx	222	26	1991	1991	CD
cord-280549-bsnz24jx	222	27	;	;	:
cord-280549-bsnz24jx	223	1	Mannick	Mannick	NNP
cord-280549-bsnz24jx	223	2	et	et	NNP
cord-280549-bsnz24jx	223	3	al	al	NNP
cord-280549-bsnz24jx	223	4	.	.	NNP
cord-280549-bsnz24jx	223	5	,	,	,
cord-280549-bsnz24jx	223	6	1991	1991	CD
cord-280549-bsnz24jx	224	1	;	;	:
cord-280549-bsnz24jx	224	2	Szekely	Szekely	NNP
cord-280549-bsnz24jx	224	3	et	et	NNP
cord-280549-bsnz24jx	224	4	al	al	NNP
cord-280549-bsnz24jx	224	5	.	.	NNP
cord-280549-bsnz24jx	224	6	,	,	,
cord-280549-bsnz24jx	224	7	1993	1993	CD
cord-280549-bsnz24jx	224	8	)	)	-RRB-
cord-280549-bsnz24jx	224	9	,	,	,
cord-280549-bsnz24jx	224	10	the	the	DT
cord-280549-bsnz24jx	224	11	Rb	Rb	NNP
cord-280549-bsnz24jx	224	12	binding	bind	VBG
cord-280549-bsnz24jx	224	13	region	region	NN
cord-280549-bsnz24jx	224	14	on	on	IN
cord-280549-bsnz24jx	224	15	EBNA-5	EBNA-5	NNP
cord-280549-bsnz24jx	224	16	was	be	VBD
cord-280549-bsnz24jx	224	17	mapped	map	VBN
cord-280549-bsnz24jx	224	18	to	to	IN
cord-280549-bsnz24jx	224	19	a	a	DT
cord-280549-bsnz24jx	224	20	66-amino	66-amino	CD
cord-280549-bsnz24jx	224	21	acid	acid	NN
cord-280549-bsnz24jx	224	22	-	-	HYPH
cord-280549-bsnz24jx	224	23	long	long	JJ
cord-280549-bsnz24jx	224	24	peptide	peptide	NN
cord-280549-bsnz24jx	224	25	that	that	WDT
cord-280549-bsnz24jx	224	26	locates	locate	VBZ
cord-280549-bsnz24jx	224	27	on	on	IN
cord-280549-bsnz24jx	224	28	the	the	DT
cord-280549-bsnz24jx	224	29	N	n	CD
cord-280549-bsnz24jx	224	30	-	-	HYPH
cord-280549-bsnz24jx	224	31	terminal	terminal	JJ
cord-280549-bsnz24jx	224	32	half	half	NN
cord-280549-bsnz24jx	224	33	of	of	IN
cord-280549-bsnz24jx	224	34	this	this	DT
cord-280549-bsnz24jx	224	35	viral	viral	JJ
cord-280549-bsnz24jx	224	36	protein	protein	NN
cord-280549-bsnz24jx	224	37	,	,	,
cord-280549-bsnz24jx	224	38	which	which	WDT
cord-280549-bsnz24jx	224	39	is	be	VBZ
cord-280549-bsnz24jx	224	40	also	also	RB
cord-280549-bsnz24jx	224	41	the	the	DT
cord-280549-bsnz24jx	224	42	binding	binding	NN
cord-280549-bsnz24jx	224	43	site	site	NN
cord-280549-bsnz24jx	224	44	for	for	IN
cord-280549-bsnz24jx	224	45	p53	p53	NN
cord-280549-bsnz24jx	225	1	(	(	-LRB-
cord-280549-bsnz24jx	225	2	Szekely	Szekely	NNP
cord-280549-bsnz24jx	225	3	et	et	NNP
cord-280549-bsnz24jx	225	4	al	al	NNP
cord-280549-bsnz24jx	225	5	.	.	NNP
cord-280549-bsnz24jx	225	6	,	,	,
cord-280549-bsnz24jx	225	7	1993	1993	CD
cord-280549-bsnz24jx	225	8	)	)	-RRB-
cord-280549-bsnz24jx	225	9	.	.	.
cord-280549-bsnz24jx	226	1	It	-PRON-	PRP
cord-280549-bsnz24jx	226	2	was	be	VBD
cord-280549-bsnz24jx	226	3	found	find	VBN
cord-280549-bsnz24jx	226	4	that	that	IN
cord-280549-bsnz24jx	226	5	p53	p53	NN
cord-280549-bsnz24jx	226	6	competes	compete	VBZ
cord-280549-bsnz24jx	226	7	with	with	IN
cord-280549-bsnz24jx	226	8	Rb	Rb	NNP
cord-280549-bsnz24jx	226	9	for	for	IN
cord-280549-bsnz24jx	226	10	EBNA-5	EBNA-5	NNS
cord-280549-bsnz24jx	226	11	binding	bind	VBG
cord-280549-bsnz24jx	226	12	as	as	IN
cord-280549-bsnz24jx	226	13	it	-PRON-	PRP
cord-280549-bsnz24jx	226	14	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	226	15	EBNA-5-Rb	ebna-5-rb	NN
cord-280549-bsnz24jx	226	16	complex	complex	JJ
cord-280549-bsnz24jx	226	17	formation	formation	NN
cord-280549-bsnz24jx	226	18	in	in	IN
cord-280549-bsnz24jx	226	19	vitro	vitro	FW
cord-280549-bsnz24jx	226	20	in	in	IN
cord-280549-bsnz24jx	226	21	a	a	DT
cord-280549-bsnz24jx	226	22	dose	dose	NN
cord-280549-bsnz24jx	226	23	-	-	HYPH
cord-280549-bsnz24jx	226	24	dependent	dependent	JJ
cord-280549-bsnz24jx	226	25	manner	manner	NN
cord-280549-bsnz24jx	226	26	.	.	.
cord-280549-bsnz24jx	227	1	However	however	RB
cord-280549-bsnz24jx	227	2	,	,	,
cord-280549-bsnz24jx	227	3	inhibition	inhibition	NN
cord-280549-bsnz24jx	227	4	of	of	IN
cord-280549-bsnz24jx	227	5	p53-EBNA-5	p53-ebna-5	IN
cord-280549-bsnz24jx	227	6	interaction	interaction	NN
cord-280549-bsnz24jx	227	7	by	by	IN
cord-280549-bsnz24jx	227	8	Rb	Rb	NNP
cord-280549-bsnz24jx	227	9	was	be	VBD
cord-280549-bsnz24jx	227	10	not	not	RB
cord-280549-bsnz24jx	227	11	observed	observe	VBN
cord-280549-bsnz24jx	227	12	in	in	IN
cord-280549-bsnz24jx	227	13	a	a	DT
cord-280549-bsnz24jx	227	14	reciprocal	reciprocal	JJ
cord-280549-bsnz24jx	227	15	experiment	experiment	NN
cord-280549-bsnz24jx	227	16	(	(	-LRB-
cord-280549-bsnz24jx	227	17	Szekely	Szekely	NNP
cord-280549-bsnz24jx	227	18	et	et	FW
cord-280549-bsnz24jx	227	19	al	al	NNP
cord-280549-bsnz24jx	227	20	.	.	NNP
cord-280549-bsnz24jx	227	21	,	,	,
cord-280549-bsnz24jx	227	22	1993	1993	CD
cord-280549-bsnz24jx	227	23	)	)	-RRB-
cord-280549-bsnz24jx	227	24	.	.	.
cord-280549-bsnz24jx	228	1	The	the	DT
cord-280549-bsnz24jx	228	2	fact	fact	NN
cord-280549-bsnz24jx	228	3	that	that	IN
cord-280549-bsnz24jx	228	4	the	the	DT
cord-280549-bsnz24jx	228	5	transformation	transformation	NN
cord-280549-bsnz24jx	228	6	-	-	HYPH
cord-280549-bsnz24jx	228	7	capable	capable	JJ
cord-280549-bsnz24jx	228	8	region	region	NN
cord-280549-bsnz24jx	228	9	on	on	IN
cord-280549-bsnz24jx	228	10	EBNA-5	EBNA-5	NNP
cord-280549-bsnz24jx	228	11	is	be	VBZ
cord-280549-bsnz24jx	228	12	distinct	distinct	JJ
cord-280549-bsnz24jx	228	13	from	from	IN
cord-280549-bsnz24jx	228	14	its	-PRON-	PRP$
cord-280549-bsnz24jx	228	15	Rb	Rb	NNP
cord-280549-bsnz24jx	228	16	/	/	SYM
cord-280549-bsnz24jx	228	17	p53-binding	p53-binding	NN
cord-280549-bsnz24jx	228	18	motif	motif	NN
cord-280549-bsnz24jx	228	19	suggests	suggest	VBZ
cord-280549-bsnz24jx	228	20	interaction	interaction	NN
cord-280549-bsnz24jx	228	21	with	with	IN
cord-280549-bsnz24jx	228	22	Rb	Rb	NNP
cord-280549-bsnz24jx	228	23	/	/	SYM
cord-280549-bsnz24jx	228	24	p53	p53	NN
cord-280549-bsnz24jx	228	25	is	be	VBZ
cord-280549-bsnz24jx	228	26	not	not	RB
cord-280549-bsnz24jx	228	27	related	relate	VBN
cord-280549-bsnz24jx	228	28	to	to	IN
cord-280549-bsnz24jx	228	29	its	-PRON-	PRP$
cord-280549-bsnz24jx	228	30	ability	ability	NN
cord-280549-bsnz24jx	228	31	to	to	TO
cord-280549-bsnz24jx	228	32	induce	induce	VB
cord-280549-bsnz24jx	228	33	B	b	NN
cord-280549-bsnz24jx	228	34	cell	cell	NN
cord-280549-bsnz24jx	228	35	transformation	transformation	NN
cord-280549-bsnz24jx	228	36	.	.	.
cord-280549-bsnz24jx	229	1	Indeed	indeed	RB
cord-280549-bsnz24jx	229	2	,	,	,
cord-280549-bsnz24jx	229	3	Inman	Inman	NNP
cord-280549-bsnz24jx	229	4	et	et	NNP
cord-280549-bsnz24jx	229	5	al	al	NNP
cord-280549-bsnz24jx	229	6	.	.	NNP
cord-280549-bsnz24jx	229	7	showed	show	VBD
cord-280549-bsnz24jx	229	8	that	that	IN
cord-280549-bsnz24jx	229	9	expression	expression	NN
cord-280549-bsnz24jx	229	10	of	of	IN
cord-280549-bsnz24jx	229	11	EBNA-5	EBNA-5	NNP
cord-280549-bsnz24jx	229	12	could	could	MD
cord-280549-bsnz24jx	229	13	neither	neither	CC
cord-280549-bsnz24jx	229	14	relieve	relieve	VB
cord-280549-bsnz24jx	229	15	Rb	Rb	NNP
cord-280549-bsnz24jx	229	16	-	-	HYPH
cord-280549-bsnz24jx	229	17	mediated	mediate	VBN
cord-280549-bsnz24jx	229	18	repression	repression	NN
cord-280549-bsnz24jx	229	19	of	of	IN
cord-280549-bsnz24jx	229	20	E2F1	E2F1	NNP
cord-280549-bsnz24jx	229	21	transactivation	transactivation	NN
cord-280549-bsnz24jx	229	22	,	,	,
cord-280549-bsnz24jx	229	23	nor	nor	CC
cord-280549-bsnz24jx	229	24	prevent	prevent	VB
cord-280549-bsnz24jx	229	25	p53-induced	p53-induced	JJ
cord-280549-bsnz24jx	229	26	transactivation	transactivation	NN
cord-280549-bsnz24jx	229	27	(	(	-LRB-
cord-280549-bsnz24jx	229	28	Inman	Inman	NNP
cord-280549-bsnz24jx	229	29	and	and	CC
cord-280549-bsnz24jx	229	30	Farrell	Farrell	NNP
cord-280549-bsnz24jx	229	31	,	,	,
cord-280549-bsnz24jx	229	32	1995	1995	CD
cord-280549-bsnz24jx	229	33	)	)	-RRB-
cord-280549-bsnz24jx	229	34	.	.	.
cord-280549-bsnz24jx	230	1	However	however	RB
cord-280549-bsnz24jx	230	2	,	,	,
cord-280549-bsnz24jx	230	3	it	-PRON-	PRP
cord-280549-bsnz24jx	230	4	is	be	VBZ
cord-280549-bsnz24jx	230	5	possible	possible	JJ
cord-280549-bsnz24jx	230	6	that	that	IN
cord-280549-bsnz24jx	230	7	the	the	DT
cord-280549-bsnz24jx	230	8	association	association	NN
cord-280549-bsnz24jx	230	9	of	of	IN
cord-280549-bsnz24jx	230	10	EBNA-5	EBNA-5	NNP
cord-280549-bsnz24jx	230	11	to	to	IN
cord-280549-bsnz24jx	230	12	Rb	Rb	NNP
cord-280549-bsnz24jx	230	13	affects	affect	VBZ
cord-280549-bsnz24jx	230	14	other	other	JJ
cord-280549-bsnz24jx	230	15	aspects	aspect	NNS
cord-280549-bsnz24jx	230	16	of	of	IN
cord-280549-bsnz24jx	230	17	its	-PRON-	PRP$
cord-280549-bsnz24jx	230	18	function	function	NN
cord-280549-bsnz24jx	230	19	,	,	,
cord-280549-bsnz24jx	230	20	such	such	JJ
cord-280549-bsnz24jx	230	21	as	as	IN
cord-280549-bsnz24jx	230	22	its	-PRON-	PRP$
cord-280549-bsnz24jx	230	23	control	control	NN
cord-280549-bsnz24jx	230	24	of	of	IN
cord-280549-bsnz24jx	230	25	c	c	NNP
cord-280549-bsnz24jx	230	26	-	-	:
cord-280549-bsnz24jx	230	27	Abl	Abl	NNP
cord-280549-bsnz24jx	230	28	tyrosine	tyrosine	NN
cord-280549-bsnz24jx	230	29	kinase	kinase	NN
cord-280549-bsnz24jx	230	30	,	,	,
cord-280549-bsnz24jx	230	31	to	to	TO
cord-280549-bsnz24jx	230	32	aid	aid	VB
cord-280549-bsnz24jx	230	33	in	in	IN
cord-280549-bsnz24jx	230	34	viral	viral	JJ
cord-280549-bsnz24jx	230	35	infection	infection	NN
cord-280549-bsnz24jx	230	36	.	.	.
cord-280549-bsnz24jx	231	1	In	in	IN
cord-280549-bsnz24jx	231	2	addition	addition	NN
cord-280549-bsnz24jx	231	3	,	,	,
cord-280549-bsnz24jx	231	4	Zancy	Zancy	NNP
cord-280549-bsnz24jx	231	5	et	et	FW
cord-280549-bsnz24jx	231	6	al	al	NNP
cord-280549-bsnz24jx	231	7	.	.	NNP
cord-280549-bsnz24jx	231	8	reported	report	VBD
cord-280549-bsnz24jx	231	9	an	an	DT
cord-280549-bsnz24jx	231	10	interaction	interaction	NN
cord-280549-bsnz24jx	231	11	of	of	IN
cord-280549-bsnz24jx	231	12	EBV	EBV	NNP
cord-280549-bsnz24jx	231	13	immediate	immediate	JJ
cord-280549-bsnz24jx	231	14	-	-	HYPH
cord-280549-bsnz24jx	231	15	early	early	JJ
cord-280549-bsnz24jx	231	16	lytic	lytic	JJ
cord-280549-bsnz24jx	231	17	gene	gene	NN
cord-280549-bsnz24jx	231	18	product	product	NN
cord-280549-bsnz24jx	231	19	BRLF1	BRLF1	NNP
cord-280549-bsnz24jx	231	20	with	with	IN
cord-280549-bsnz24jx	231	21	Rb	Rb	NNP
cord-280549-bsnz24jx	231	22	in	in	IN
cord-280549-bsnz24jx	231	23	virus	virus	NN
cord-280549-bsnz24jx	231	24	-	-	HYPH
cord-280549-bsnz24jx	231	25	infected	infect	VBN
cord-280549-bsnz24jx	231	26	cells	cell	NNS
cord-280549-bsnz24jx	231	27	(	(	-LRB-
cord-280549-bsnz24jx	231	28	Zacny	Zacny	NNP
cord-280549-bsnz24jx	231	29	et	et	NNP
cord-280549-bsnz24jx	231	30	al	al	NNP
cord-280549-bsnz24jx	231	31	.	.	NNP
cord-280549-bsnz24jx	231	32	,	,	,
cord-280549-bsnz24jx	231	33	1998	1998	CD
cord-280549-bsnz24jx	231	34	)	)	-RRB-
cord-280549-bsnz24jx	231	35	.	.	.
cord-280549-bsnz24jx	232	1	Although	although	IN
cord-280549-bsnz24jx	232	2	the	the	DT
cord-280549-bsnz24jx	232	3	interaction	interaction	NN
cord-280549-bsnz24jx	232	4	motif	motif	NN
cord-280549-bsnz24jx	232	5	on	on	IN
cord-280549-bsnz24jx	232	6	Rb	Rb	NNP
cord-280549-bsnz24jx	232	7	for	for	IN
cord-280549-bsnz24jx	232	8	BRLF1	BRLF1	NNP
cord-280549-bsnz24jx	232	9	binding	binding	NN
cord-280549-bsnz24jx	232	10	is	be	VBZ
cord-280549-bsnz24jx	232	11	outside	outside	RB
cord-280549-bsnz24jx	232	12	of	of	IN
cord-280549-bsnz24jx	232	13	its	-PRON-	PRP$
cord-280549-bsnz24jx	232	14	pocket	pocket	NN
cord-280549-bsnz24jx	232	15	region	region	NN
cord-280549-bsnz24jx	232	16	and	and	CC
cord-280549-bsnz24jx	232	17	BRLF1	BRLF1	NNP
cord-280549-bsnz24jx	232	18	does	do	VBZ
cord-280549-bsnz24jx	232	19	not	not	RB
cord-280549-bsnz24jx	232	20	interact	interact	VB
cord-280549-bsnz24jx	232	21	with	with	IN
cord-280549-bsnz24jx	232	22	E2F	E2F	NNP
cord-280549-bsnz24jx	232	23	,	,	,
cord-280549-bsnz24jx	232	24	a	a	DT
cord-280549-bsnz24jx	232	25	correlation	correlation	NN
cord-280549-bsnz24jx	232	26	was	be	VBD
cord-280549-bsnz24jx	232	27	still	still	RB
cord-280549-bsnz24jx	232	28	observed	observe	VBN
cord-280549-bsnz24jx	232	29	between	between	IN
cord-280549-bsnz24jx	232	30	the	the	DT
cord-280549-bsnz24jx	232	31	kinetics	kinetic	NNS
cord-280549-bsnz24jx	232	32	of	of	IN
cord-280549-bsnz24jx	232	33	BRLF1-Rb	BRLF1-Rb	NNP
cord-280549-bsnz24jx	232	34	binding	binding	NN
cord-280549-bsnz24jx	232	35	and	and	CC
cord-280549-bsnz24jx	232	36	the	the	DT
cord-280549-bsnz24jx	232	37	displacement	displacement	NN
cord-280549-bsnz24jx	232	38	of	of	IN
cord-280549-bsnz24jx	232	39	E2F1	E2F1	NNP
cord-280549-bsnz24jx	232	40	from	from	IN
cord-280549-bsnz24jx	232	41	Rb	Rb	NNP
cord-280549-bsnz24jx	232	42	,	,	,
cord-280549-bsnz24jx	232	43	suggesting	suggest	VBG
cord-280549-bsnz24jx	232	44	the	the	DT
cord-280549-bsnz24jx	232	45	potential	potential	NN
cord-280549-bsnz24jx	232	46	of	of	IN
cord-280549-bsnz24jx	232	47	BRLF1	BRLF1	NNP
cord-280549-bsnz24jx	232	48	in	in	IN
cord-280549-bsnz24jx	232	49	initiating	initiate	VBG
cord-280549-bsnz24jx	232	50	cell	cell	NN
cord-280549-bsnz24jx	232	51	cycle	cycle	NN
cord-280549-bsnz24jx	232	52	progression	progression	NN
cord-280549-bsnz24jx	232	53	(	(	-LRB-
cord-280549-bsnz24jx	232	54	Zacny	Zacny	NNP
cord-280549-bsnz24jx	232	55	et	et	NNP
cord-280549-bsnz24jx	232	56	al	al	NNP
cord-280549-bsnz24jx	232	57	.	.	NNP
cord-280549-bsnz24jx	232	58	,	,	,
cord-280549-bsnz24jx	232	59	1998	1998	CD
cord-280549-bsnz24jx	232	60	)	)	-RRB-
cord-280549-bsnz24jx	232	61	.	.	.
cord-280549-bsnz24jx	233	1	Checkpoint	checkpoint	NN
cord-280549-bsnz24jx	233	2	kinase	kinase	NN
cord-280549-bsnz24jx	233	3	(	(	-LRB-
cord-280549-bsnz24jx	233	4	Chk	Chk	NNP
cord-280549-bsnz24jx	233	5	)	)	-RRB-
cord-280549-bsnz24jx	233	6	1	1	CD
cord-280549-bsnz24jx	233	7	and	and	CC
cord-280549-bsnz24jx	233	8	2	2	CD
cord-280549-bsnz24jx	233	9	are	be	VBP
cord-280549-bsnz24jx	233	10	tumor	tumor	NN
cord-280549-bsnz24jx	233	11	repressor	repressor	NN
cord-280549-bsnz24jx	233	12	proteins	protein	NNS
cord-280549-bsnz24jx	233	13	that	that	WDT
cord-280549-bsnz24jx	233	14	are	be	VBP
cord-280549-bsnz24jx	233	15	activated	activate	VBN
cord-280549-bsnz24jx	233	16	upon	upon	IN
cord-280549-bsnz24jx	233	17	replication	replication	NN
cord-280549-bsnz24jx	233	18	defect	defect	NN
cord-280549-bsnz24jx	233	19	and/or	and/or	CC
cord-280549-bsnz24jx	233	20	DNA	dna	NN
cord-280549-bsnz24jx	233	21	damage	damage	NN
cord-280549-bsnz24jx	234	1	(	(	-LRB-
cord-280549-bsnz24jx	234	2	Bartek	Bartek	NNP
cord-280549-bsnz24jx	234	3	and	and	CC
cord-280549-bsnz24jx	234	4	Lukas	Lukas	NNP
cord-280549-bsnz24jx	234	5	,	,	,
cord-280549-bsnz24jx	234	6	2003	2003	CD
cord-280549-bsnz24jx	234	7	;	;	:
cord-280549-bsnz24jx	234	8	Haoudi	Haoudi	NNP
cord-280549-bsnz24jx	234	9	et	et	NNP
cord-280549-bsnz24jx	234	10	al	al	NNP
cord-280549-bsnz24jx	234	11	.	.	NNP
cord-280549-bsnz24jx	234	12	,	,	,
cord-280549-bsnz24jx	234	13	2003	2003	CD
cord-280549-bsnz24jx	234	14	;	;	:
cord-280549-bsnz24jx	235	1	Park	Park	NNP
cord-280549-bsnz24jx	235	2	et	et	FW
cord-280549-bsnz24jx	235	3	al	al	NNP
cord-280549-bsnz24jx	235	4	.	.	NNP
cord-280549-bsnz24jx	235	5	,	,	,
cord-280549-bsnz24jx	235	6	2004	2004	CD
cord-280549-bsnz24jx	236	1	Park	Park	NNP
cord-280549-bsnz24jx	236	2	et	et	FW
cord-280549-bsnz24jx	236	3	al	al	NNP
cord-280549-bsnz24jx	236	4	.	.	NNP
cord-280549-bsnz24jx	236	5	,	,	,
cord-280549-bsnz24jx	236	6	,	,	,
cord-280549-bsnz24jx	236	7	2006	2006	CD
cord-280549-bsnz24jx	236	8	.	.	.
cord-280549-bsnz24jx	237	1	Being	be	VBG
cord-280549-bsnz24jx	237	2	a	a	DT
cord-280549-bsnz24jx	237	3	multifunctional	multifunctional	JJ
cord-280549-bsnz24jx	237	4	viral	viral	JJ
cord-280549-bsnz24jx	237	5	protein	protein	NN
cord-280549-bsnz24jx	237	6	,	,	,
cord-280549-bsnz24jx	237	7	Tax	Tax	NNP
cord-280549-bsnz24jx	237	8	of	of	IN
cord-280549-bsnz24jx	237	9	HTLV-1	HTLV-1	NNP
cord-280549-bsnz24jx	237	10	is	be	VBZ
cord-280549-bsnz24jx	237	11	also	also	RB
cord-280549-bsnz24jx	237	12	known	know	VBN
cord-280549-bsnz24jx	237	13	to	to	TO
cord-280549-bsnz24jx	237	14	interact	interact	VB
cord-280549-bsnz24jx	237	15	with	with	IN
cord-280549-bsnz24jx	237	16	Chk	Chk	NNP
cord-280549-bsnz24jx	237	17	.	.	.
cord-280549-bsnz24jx	238	1	Thus	thus	RB
cord-280549-bsnz24jx	238	2	,	,	,
cord-280549-bsnz24jx	238	3	expression	expression	NN
cord-280549-bsnz24jx	238	4	of	of	IN
cord-280549-bsnz24jx	238	5	Tax	tax	NN
cord-280549-bsnz24jx	238	6	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	238	7	the	the	DT
cord-280549-bsnz24jx	238	8	kinase	kinase	NN
cord-280549-bsnz24jx	238	9	activity	activity	NN
cord-280549-bsnz24jx	238	10	of	of	IN
cord-280549-bsnz24jx	238	11	Chk1	Chk1	NNP
cord-280549-bsnz24jx	238	12	,	,	,
cord-280549-bsnz24jx	238	13	whereas	whereas	IN
cord-280549-bsnz24jx	238	14	the	the	DT
cord-280549-bsnz24jx	238	15	effect	effect	NN
cord-280549-bsnz24jx	238	16	of	of	IN
cord-280549-bsnz24jx	238	17	Tax	tax	NN
cord-280549-bsnz24jx	238	18	on	on	IN
cord-280549-bsnz24jx	238	19	the	the	DT
cord-280549-bsnz24jx	238	20	kinase	kinase	NN
cord-280549-bsnz24jx	238	21	activity	activity	NN
cord-280549-bsnz24jx	238	22	of	of	IN
cord-280549-bsnz24jx	238	23	Chk2	Chk2	NNP
cord-280549-bsnz24jx	238	24	is	be	VBZ
cord-280549-bsnz24jx	238	25	controversial	controversial	JJ
cord-280549-bsnz24jx	238	26	.	.	.
cord-280549-bsnz24jx	239	1	Park	Park	NNP
cord-280549-bsnz24jx	239	2	et	et	FW
cord-280549-bsnz24jx	239	3	al	al	NNP
cord-280549-bsnz24jx	239	4	.	.	NNP
cord-280549-bsnz24jx	239	5	showed	show	VBD
cord-280549-bsnz24jx	239	6	that	that	IN
cord-280549-bsnz24jx	239	7	Cdc25A	Cdc25A	NNP
cord-280549-bsnz24jx	240	1	degradation	degradation	NN
cord-280549-bsnz24jx	240	2	and	and	CC
cord-280549-bsnz24jx	240	3	p53	p53	NN
cord-280549-bsnz24jx	240	4	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	240	5	(	(	-LRB-
cord-280549-bsnz24jx	240	6	Ser20	Ser20	NNP
cord-280549-bsnz24jx	240	7	)	)	-RRB-
cord-280549-bsnz24jx	240	8	,	,	,
cord-280549-bsnz24jx	240	9	the	the	DT
cord-280549-bsnz24jx	240	10	downstream	downstream	JJ
cord-280549-bsnz24jx	240	11	events	event	NNS
cord-280549-bsnz24jx	240	12	of	of	IN
cord-280549-bsnz24jx	240	13	Chk1	Chk1	NNP
cord-280549-bsnz24jx	240	14	activation	activation	NN
cord-280549-bsnz24jx	240	15	,	,	,
cord-280549-bsnz24jx	240	16	were	be	VBD
cord-280549-bsnz24jx	240	17	attenuated	attenuate	VBN
cord-280549-bsnz24jx	240	18	by	by	IN
cord-280549-bsnz24jx	240	19	Tax	tax	NN
cord-280549-bsnz24jx	240	20	expression	expression	NN
cord-280549-bsnz24jx	240	21	in	in	IN
cord-280549-bsnz24jx	240	22	a	a	DT
cord-280549-bsnz24jx	240	23	dose	dose	NN
cord-280549-bsnz24jx	240	24	-	-	HYPH
cord-280549-bsnz24jx	240	25	dependent	dependent	JJ
cord-280549-bsnz24jx	240	26	manner	manner	NN
cord-280549-bsnz24jx	240	27	,	,	,
cord-280549-bsnz24jx	240	28	suggesting	suggest	VBG
cord-280549-bsnz24jx	240	29	that	that	IN
cord-280549-bsnz24jx	240	30	Tax	tax	NN
cord-280549-bsnz24jx	240	31	inactivates	inactivate	VBZ
cord-280549-bsnz24jx	240	32	Chk1	chk1	VBP
cord-280549-bsnz24jx	240	33	(	(	-LRB-
cord-280549-bsnz24jx	240	34	Hirao	Hirao	NNP
cord-280549-bsnz24jx	240	35	et	et	NNP
cord-280549-bsnz24jx	240	36	al	al	NNP
cord-280549-bsnz24jx	240	37	.	.	NNP
cord-280549-bsnz24jx	240	38	,	,	,
cord-280549-bsnz24jx	240	39	2000	2000	CD
cord-280549-bsnz24jx	240	40	;	;	:
cord-280549-bsnz24jx	240	41	Shieh	Shieh	NNP
cord-280549-bsnz24jx	240	42	et	et	NNP
cord-280549-bsnz24jx	240	43	al	al	NNP
cord-280549-bsnz24jx	240	44	.	.	NNP
cord-280549-bsnz24jx	240	45	,	,	,
cord-280549-bsnz24jx	240	46	2000	2000	CD
cord-280549-bsnz24jx	240	47	;	;	:
cord-280549-bsnz24jx	240	48	Xiao	Xiao	NNP
cord-280549-bsnz24jx	240	49	et	et	NNP
cord-280549-bsnz24jx	240	50	al	al	NNP
cord-280549-bsnz24jx	240	51	.	.	.
cord-280549-bsnz24jx	241	1	,	,	,
cord-280549-bsnz24jx	241	2	2003	2003	CD
cord-280549-bsnz24jx	241	3	;	;	:
cord-280549-bsnz24jx	241	4	Park	Park	NNP
cord-280549-bsnz24jx	241	5	et	et	FW
cord-280549-bsnz24jx	241	6	al	al	NNP
cord-280549-bsnz24jx	241	7	.	.	NNP
cord-280549-bsnz24jx	241	8	,	,	,
cord-280549-bsnz24jx	241	9	2004	2004	CD
cord-280549-bsnz24jx	241	10	)	)	-RRB-
cord-280549-bsnz24jx	241	11	.	.	.
cord-280549-bsnz24jx	242	1	Two	two	CD
cord-280549-bsnz24jx	242	2	domains	domain	NNS
cord-280549-bsnz24jx	242	3	on	on	IN
cord-280549-bsnz24jx	242	4	Tax	tax	NN
cord-280549-bsnz24jx	242	5	were	be	VBD
cord-280549-bsnz24jx	242	6	identified	identify	VBN
cord-280549-bsnz24jx	242	7	to	to	TO
cord-280549-bsnz24jx	242	8	be	be	VB
cord-280549-bsnz24jx	242	9	important	important	JJ
cord-280549-bsnz24jx	242	10	for	for	IN
cord-280549-bsnz24jx	242	11	both	both	DT
cord-280549-bsnz24jx	242	12	binding	bind	VBG
cord-280549-bsnz24jx	242	13	to	to	IN
cord-280549-bsnz24jx	242	14	and	and	CC
cord-280549-bsnz24jx	242	15	inhibition	inhibition	NN
cord-280549-bsnz24jx	242	16	of	of	IN
cord-280549-bsnz24jx	242	17	Chk2	Chk2	NNP
cord-280549-bsnz24jx	242	18	,	,	,
cord-280549-bsnz24jx	242	19	drawing	draw	VBG
cord-280549-bsnz24jx	242	20	a	a	DT
cord-280549-bsnz24jx	242	21	causal	causal	JJ
cord-280549-bsnz24jx	242	22	relationship	relationship	NN
cord-280549-bsnz24jx	242	23	between	between	IN
cord-280549-bsnz24jx	242	24	physical	physical	JJ
cord-280549-bsnz24jx	242	25	protein	protein	NN
cord-280549-bsnz24jx	242	26	interaction	interaction	NN
cord-280549-bsnz24jx	242	27	and	and	CC
cord-280549-bsnz24jx	242	28	the	the	DT
cord-280549-bsnz24jx	242	29	functional	functional	JJ
cord-280549-bsnz24jx	242	30	inactivation	inactivation	NN
cord-280549-bsnz24jx	242	31	of	of	IN
cord-280549-bsnz24jx	242	32	Chk	Chk	NNP
cord-280549-bsnz24jx	242	33	family	family	NN
cord-280549-bsnz24jx	242	34	of	of	IN
cord-280549-bsnz24jx	242	35	tumor	tumor	NN
cord-280549-bsnz24jx	242	36	repressors	repressor	NNS
cord-280549-bsnz24jx	242	37	(	(	-LRB-
cord-280549-bsnz24jx	242	38	Park	Park	NNP
cord-280549-bsnz24jx	242	39	et	et	FW
cord-280549-bsnz24jx	242	40	al	al	NNP
cord-280549-bsnz24jx	242	41	.	.	NNP
cord-280549-bsnz24jx	242	42	,	,	,
cord-280549-bsnz24jx	242	43	2006	2006	CD
cord-280549-bsnz24jx	242	44	)	)	-RRB-
cord-280549-bsnz24jx	242	45	.	.	.
cord-280549-bsnz24jx	243	1	By	by	IN
cord-280549-bsnz24jx	243	2	contrast	contrast	NN
cord-280549-bsnz24jx	243	3	,	,	,
cord-280549-bsnz24jx	243	4	Haoudi	Haoudi	NNP
cord-280549-bsnz24jx	243	5	et	et	NNP
cord-280549-bsnz24jx	243	6	al	al	NNP
cord-280549-bsnz24jx	243	7	.	.	NNP
cord-280549-bsnz24jx	243	8	described	describe	VBD
cord-280549-bsnz24jx	243	9	an	an	DT
cord-280549-bsnz24jx	243	10	induction	induction	NN
cord-280549-bsnz24jx	243	11	of	of	IN
cord-280549-bsnz24jx	243	12	the	the	DT
cord-280549-bsnz24jx	243	13	steady	steady	JJ
cord-280549-bsnz24jx	243	14	-	-	HYPH
cord-280549-bsnz24jx	243	15	state	state	NN
cord-280549-bsnz24jx	243	16	level	level	NN
cord-280549-bsnz24jx	243	17	of	of	IN
cord-280549-bsnz24jx	243	18	Chk2	Chk2	NNP
cord-280549-bsnz24jx	243	19	,	,	,
cord-280549-bsnz24jx	243	20	but	but	CC
cord-280549-bsnz24jx	243	21	not	not	RB
cord-280549-bsnz24jx	243	22	Chk1	Chk1	VBN
cord-280549-bsnz24jx	243	23	,	,	,
cord-280549-bsnz24jx	243	24	by	by	IN
cord-280549-bsnz24jx	243	25	Tax	tax	NN
cord-280549-bsnz24jx	243	26	with	with	IN
cord-280549-bsnz24jx	243	27	increased	increase	VBN
cord-280549-bsnz24jx	243	28	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	243	29	degradation	degradation	NN
cord-280549-bsnz24jx	243	30	and	and	CC
cord-280549-bsnz24jx	243	31	p53	p53	NN
cord-280549-bsnz24jx	243	32	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	243	33	(	(	-LRB-
cord-280549-bsnz24jx	243	34	Ser15	Ser15	NNP
cord-280549-bsnz24jx	243	35	)	)	-RRB-
cord-280549-bsnz24jx	244	1	(	(	-LRB-
cord-280549-bsnz24jx	244	2	Haoudi	Haoudi	NNP
cord-280549-bsnz24jx	244	3	et	et	FW
cord-280549-bsnz24jx	244	4	al	al	NNP
cord-280549-bsnz24jx	244	5	.	.	NNP
cord-280549-bsnz24jx	244	6	,	,	,
cord-280549-bsnz24jx	244	7	2003	2003	CD
cord-280549-bsnz24jx	244	8	)	)	-RRB-
cord-280549-bsnz24jx	244	9	.	.	.
cord-280549-bsnz24jx	245	1	Despite	despite	IN
cord-280549-bsnz24jx	245	2	the	the	DT
cord-280549-bsnz24jx	245	3	fact	fact	NN
cord-280549-bsnz24jx	245	4	that	that	IN
cord-280549-bsnz24jx	245	5	Chk2	Chk2	NNP
cord-280549-bsnz24jx	245	6	was	be	VBD
cord-280549-bsnz24jx	245	7	revealed	reveal	VBN
cord-280549-bsnz24jx	245	8	to	to	TO
cord-280549-bsnz24jx	245	9	be	be	VB
cord-280549-bsnz24jx	245	10	activated	activate	VBN
cord-280549-bsnz24jx	245	11	by	by	IN
cord-280549-bsnz24jx	245	12	Tax	Tax	NNP
cord-280549-bsnz24jx	245	13	,	,	,
cord-280549-bsnz24jx	245	14	the	the	DT
cord-280549-bsnz24jx	245	15	overall	overall	JJ
cord-280549-bsnz24jx	245	16	response	response	NN
cord-280549-bsnz24jx	245	17	of	of	IN
cord-280549-bsnz24jx	245	18	Chk2	Chk2	NNP
cord-280549-bsnz24jx	245	19	to	to	IN
cord-280549-bsnz24jx	245	20	DNA	dna	NN
cord-280549-bsnz24jx	245	21	damage	damage	NN
cord-280549-bsnz24jx	245	22	was	be	VBD
cord-280549-bsnz24jx	245	23	impaired	impair	VBN
cord-280549-bsnz24jx	245	24	through	through	IN
cord-280549-bsnz24jx	245	25	inhibiting	inhibit	VBG
cord-280549-bsnz24jx	245	26	the	the	DT
cord-280549-bsnz24jx	245	27	release	release	NN
cord-280549-bsnz24jx	245	28	of	of	IN
cord-280549-bsnz24jx	245	29	Chk2	Chk2	NNP
cord-280549-bsnz24jx	245	30	from	from	IN
cord-280549-bsnz24jx	245	31	chromatin	chromatin	NN
cord-280549-bsnz24jx	245	32	,	,	,
cord-280549-bsnz24jx	245	33	which	which	WDT
cord-280549-bsnz24jx	245	34	is	be	VBZ
cord-280549-bsnz24jx	245	35	normally	normally	RB
cord-280549-bsnz24jx	245	36	observed	observe	VBN
cord-280549-bsnz24jx	245	37	upon	upon	IN
cord-280549-bsnz24jx	245	38	exposure	exposure	NN
cord-280549-bsnz24jx	245	39	to	to	IN
cord-280549-bsnz24jx	245	40	ionizing	ionize	VBG
cord-280549-bsnz24jx	245	41	radiation	radiation	NN
cord-280549-bsnz24jx	246	1	(	(	-LRB-
cord-280549-bsnz24jx	246	2	Li	Li	NNP
cord-280549-bsnz24jx	246	3	and	and	CC
cord-280549-bsnz24jx	246	4	Stern	Stern	NNP
cord-280549-bsnz24jx	246	5	,	,	,
cord-280549-bsnz24jx	246	6	2005a	2005a	CD
cord-280549-bsnz24jx	246	7	;	;	:
cord-280549-bsnz24jx	246	8	Gupta	Gupta	NNP
cord-280549-bsnz24jx	246	9	et	et	NNP
cord-280549-bsnz24jx	246	10	al	al	NNP
cord-280549-bsnz24jx	246	11	.	.	NNP
cord-280549-bsnz24jx	246	12	,	,	,
cord-280549-bsnz24jx	246	13	2007	2007	CD
cord-280549-bsnz24jx	246	14	)	)	-RRB-
cord-280549-bsnz24jx	246	15	.	.	.
cord-280549-bsnz24jx	247	1	This	this	DT
cord-280549-bsnz24jx	247	2	discrepancy	discrepancy	NN
cord-280549-bsnz24jx	247	3	in	in	IN
cord-280549-bsnz24jx	247	4	the	the	DT
cord-280549-bsnz24jx	247	5	regulatory	regulatory	JJ
cord-280549-bsnz24jx	247	6	role	role	NN
cord-280549-bsnz24jx	247	7	of	of	IN
cord-280549-bsnz24jx	247	8	Tax	Tax	NNP
cord-280549-bsnz24jx	247	9	on	on	IN
cord-280549-bsnz24jx	247	10	Chk2	Chk2	NNP
cord-280549-bsnz24jx	247	11	activity	activity	NN
cord-280549-bsnz24jx	247	12	may	may	MD
cord-280549-bsnz24jx	247	13	be	be	VB
cord-280549-bsnz24jx	247	14	explained	explain	VBN
cord-280549-bsnz24jx	247	15	by	by	IN
cord-280549-bsnz24jx	247	16	the	the	DT
cord-280549-bsnz24jx	247	17	differences	difference	NNS
cord-280549-bsnz24jx	247	18	in	in	IN
cord-280549-bsnz24jx	247	19	the	the	DT
cord-280549-bsnz24jx	247	20	assay	assay	NN
cord-280549-bsnz24jx	247	21	systems	system	NNS
cord-280549-bsnz24jx	247	22	adopted	adopt	VBN
cord-280549-bsnz24jx	247	23	by	by	IN
cord-280549-bsnz24jx	247	24	these	these	DT
cord-280549-bsnz24jx	247	25	studies	study	NNS
cord-280549-bsnz24jx	247	26	.	.	.
cord-280549-bsnz24jx	248	1	Alternatively	alternatively	RB
cord-280549-bsnz24jx	248	2	,	,	,
cord-280549-bsnz24jx	248	3	it	-PRON-	PRP
cord-280549-bsnz24jx	248	4	may	may	MD
cord-280549-bsnz24jx	248	5	reflect	reflect	VB
cord-280549-bsnz24jx	248	6	the	the	DT
cord-280549-bsnz24jx	248	7	dual	dual	JJ
cord-280549-bsnz24jx	248	8	action	action	NN
cord-280549-bsnz24jx	248	9	of	of	IN
cord-280549-bsnz24jx	248	10	Tax	tax	NN
cord-280549-bsnz24jx	248	11	during	during	IN
cord-280549-bsnz24jx	248	12	different	different	JJ
cord-280549-bsnz24jx	248	13	phases	phase	NNS
cord-280549-bsnz24jx	248	14	of	of	IN
cord-280549-bsnz24jx	248	15	the	the	DT
cord-280549-bsnz24jx	248	16	same	same	JJ
cord-280549-bsnz24jx	248	17	event	event	NN
cord-280549-bsnz24jx	248	18	,	,	,
cord-280549-bsnz24jx	248	19	as	as	IN
cord-280549-bsnz24jx	248	20	Tax	Tax	NNP
cord-280549-bsnz24jx	248	21	could	could	MD
cord-280549-bsnz24jx	248	22	first	first	RB
cord-280549-bsnz24jx	248	23	induce	induce	VB
cord-280549-bsnz24jx	248	24	the	the	DT
cord-280549-bsnz24jx	248	25	accumulation	accumulation	NN
cord-280549-bsnz24jx	248	26	of	of	IN
cord-280549-bsnz24jx	248	27	Cdc25C	Cdc25C	NNP
cord-280549-bsnz24jx	248	28	,	,	,
cord-280549-bsnz24jx	248	29	which	which	WDT
cord-280549-bsnz24jx	248	30	undergoes	undergo	VBZ
cord-280549-bsnz24jx	248	31	degradation	degradation	NN
cord-280549-bsnz24jx	248	32	at	at	IN
cord-280549-bsnz24jx	248	33	a	a	DT
cord-280549-bsnz24jx	248	34	later	later	JJ
cord-280549-bsnz24jx	248	35	stage	stage	NN
cord-280549-bsnz24jx	248	36	(	(	-LRB-
cord-280549-bsnz24jx	248	37	Haoudi	Haoudi	NNP
cord-280549-bsnz24jx	248	38	et	et	FW
cord-280549-bsnz24jx	248	39	al	al	NNP
cord-280549-bsnz24jx	248	40	.	.	NNP
cord-280549-bsnz24jx	248	41	,	,	,
cord-280549-bsnz24jx	248	42	2003	2003	CD
cord-280549-bsnz24jx	248	43	)	)	-RRB-
cord-280549-bsnz24jx	248	44	.	.	.
cord-280549-bsnz24jx	249	1	However	however	RB
cord-280549-bsnz24jx	249	2	,	,	,
cord-280549-bsnz24jx	249	3	regardless	regardless	RB
cord-280549-bsnz24jx	249	4	of	of	IN
cord-280549-bsnz24jx	249	5	whether	whether	IN
cord-280549-bsnz24jx	249	6	Tax	tax	NN
cord-280549-bsnz24jx	249	7	activates	activate	VBZ
cord-280549-bsnz24jx	249	8	or	or	CC
cord-280549-bsnz24jx	249	9	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	249	10	the	the	DT
cord-280549-bsnz24jx	249	11	activity	activity	NN
cord-280549-bsnz24jx	249	12	of	of	IN
cord-280549-bsnz24jx	249	13	Chk2	Chk2	NNP
cord-280549-bsnz24jx	249	14	,	,	,
cord-280549-bsnz24jx	249	15	the	the	DT
cord-280549-bsnz24jx	249	16	cellular	cellular	JJ
cord-280549-bsnz24jx	249	17	DNA	dna	NN
cord-280549-bsnz24jx	249	18	damage	damage	NN
cord-280549-bsnz24jx	249	19	response	response	NN
cord-280549-bsnz24jx	249	20	mediated	mediate	VBN
cord-280549-bsnz24jx	249	21	by	by	IN
cord-280549-bsnz24jx	249	22	Chk2	Chk2	NNP
cord-280549-bsnz24jx	249	23	is	be	VBZ
cord-280549-bsnz24jx	249	24	dampened	dampen	VBN
cord-280549-bsnz24jx	249	25	.	.	.
cord-280549-bsnz24jx	250	1	In	in	IN
cord-280549-bsnz24jx	250	2	addition	addition	NN
cord-280549-bsnz24jx	250	3	,	,	,
cord-280549-bsnz24jx	250	4	an	an	DT
cord-280549-bsnz24jx	250	5	association	association	NN
cord-280549-bsnz24jx	250	6	of	of	IN
cord-280549-bsnz24jx	250	7	Tax	Tax	NNP
cord-280549-bsnz24jx	250	8	with	with	IN
cord-280549-bsnz24jx	250	9	the	the	DT
cord-280549-bsnz24jx	250	10	DNAdependent	dnadependent	NN
cord-280549-bsnz24jx	250	11	protein	protein	NN
cord-280549-bsnz24jx	250	12	kinase	kinase	NN
cord-280549-bsnz24jx	250	13	(	(	-LRB-
cord-280549-bsnz24jx	250	14	DNA	dna	NN
cord-280549-bsnz24jx	250	15	-	-	HYPH
cord-280549-bsnz24jx	250	16	PK	PK	NNP
cord-280549-bsnz24jx	250	17	)	)	-RRB-
cord-280549-bsnz24jx	250	18	,	,	,
cord-280549-bsnz24jx	250	19	an	an	DT
cord-280549-bsnz24jx	250	20	early	early	JJ
cord-280549-bsnz24jx	250	21	mediator	mediator	NN
cord-280549-bsnz24jx	250	22	of	of	IN
cord-280549-bsnz24jx	250	23	cell	cell	NN
cord-280549-bsnz24jx	250	24	cycle	cycle	NN
cord-280549-bsnz24jx	250	25	arrest	arrest	NN
cord-280549-bsnz24jx	250	26	via	via	IN
cord-280549-bsnz24jx	250	27	the	the	DT
cord-280549-bsnz24jx	250	28	activation	activation	NN
cord-280549-bsnz24jx	250	29	of	of	IN
cord-280549-bsnz24jx	250	30	Chk2	Chk2	NNP
cord-280549-bsnz24jx	250	31	,	,	,
cord-280549-bsnz24jx	250	32	has	have	VBZ
cord-280549-bsnz24jx	250	33	also	also	RB
cord-280549-bsnz24jx	250	34	been	be	VBN
cord-280549-bsnz24jx	250	35	reported	report	VBN
cord-280549-bsnz24jx	250	36	(	(	-LRB-
cord-280549-bsnz24jx	250	37	Li	Li	NNP
cord-280549-bsnz24jx	250	38	and	and	CC
cord-280549-bsnz24jx	250	39	Stern	Stern	NNP
cord-280549-bsnz24jx	250	40	,	,	,
cord-280549-bsnz24jx	250	41	2005b	2005b	CD
cord-280549-bsnz24jx	250	42	;	;	:
cord-280549-bsnz24jx	250	43	Durkin	Durkin	NNP
cord-280549-bsnz24jx	250	44	et	et	NNP
cord-280549-bsnz24jx	250	45	al	al	NNP
cord-280549-bsnz24jx	250	46	.	.	NNP
cord-280549-bsnz24jx	250	47	,	,	,
cord-280549-bsnz24jx	250	48	2008	2008	CD
cord-280549-bsnz24jx	250	49	)	)	-RRB-
cord-280549-bsnz24jx	250	50	.	.	.
cord-280549-bsnz24jx	251	1	Durkin	Durkin	NNP
cord-280549-bsnz24jx	251	2	et	et	NNP
cord-280549-bsnz24jx	251	3	al	al	NNP
cord-280549-bsnz24jx	251	4	.	.	.
cord-280549-bsnz24jx	252	1	observed	observed	JJ
cord-280549-bsnz24jx	252	2	increased	increase	VBN
cord-280549-bsnz24jx	252	3	DNA	DNA	NNP
cord-280549-bsnz24jx	252	4	-	-	HYPH
cord-280549-bsnz24jx	252	5	PK	PK	NNP
cord-280549-bsnz24jx	252	6	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	252	7	,	,	,
cord-280549-bsnz24jx	252	8	an	an	DT
cord-280549-bsnz24jx	252	9	initiating	initiate	VBG
cord-280549-bsnz24jx	252	10	event	event	NN
cord-280549-bsnz24jx	252	11	required	require	VBN
cord-280549-bsnz24jx	252	12	for	for	IN
cord-280549-bsnz24jx	252	13	the	the	DT
cord-280549-bsnz24jx	252	14	activation	activation	NN
cord-280549-bsnz24jx	252	15	of	of	IN
cord-280549-bsnz24jx	252	16	the	the	DT
cord-280549-bsnz24jx	252	17	kinase	kinase	NN
cord-280549-bsnz24jx	252	18	activity	activity	NN
cord-280549-bsnz24jx	252	19	of	of	IN
cord-280549-bsnz24jx	252	20	DNA	dna	NN
cord-280549-bsnz24jx	252	21	-	-	HYPH
cord-280549-bsnz24jx	252	22	PK	PK	NNP
cord-280549-bsnz24jx	252	23	(	(	-LRB-
cord-280549-bsnz24jx	252	24	Li	Li	NNP
cord-280549-bsnz24jx	252	25	and	and	CC
cord-280549-bsnz24jx	252	26	Stern	Stern	NNP
cord-280549-bsnz24jx	252	27	,	,	,
cord-280549-bsnz24jx	252	28	2005b	2005b	CD
cord-280549-bsnz24jx	252	29	)	)	-RRB-
cord-280549-bsnz24jx	252	30	,	,	,
cord-280549-bsnz24jx	252	31	in	in	IN
cord-280549-bsnz24jx	252	32	Tax	tax	NN
cord-280549-bsnz24jx	252	33	-	-	HYPH
cord-280549-bsnz24jx	252	34	expressing	express	VBG
cord-280549-bsnz24jx	252	35	cells	cell	NNS
cord-280549-bsnz24jx	252	36	(	(	-LRB-
cord-280549-bsnz24jx	252	37	Durkin	Durkin	NNP
cord-280549-bsnz24jx	252	38	et	et	NNP
cord-280549-bsnz24jx	252	39	al	al	NNP
cord-280549-bsnz24jx	252	40	.	.	NNP
cord-280549-bsnz24jx	252	41	,	,	,
cord-280549-bsnz24jx	252	42	2008	2008	CD
cord-280549-bsnz24jx	252	43	)	)	-RRB-
cord-280549-bsnz24jx	252	44	.	.	.
cord-280549-bsnz24jx	253	1	Tax	tax	NN
cord-280549-bsnz24jx	253	2	-	-	HYPH
cord-280549-bsnz24jx	253	3	induced	induce	VBN
cord-280549-bsnz24jx	253	4	constitutive	constitutive	JJ
cord-280549-bsnz24jx	253	5	signaling	signaling	NN
cord-280549-bsnz24jx	253	6	of	of	IN
cord-280549-bsnz24jx	253	7	the	the	DT
cord-280549-bsnz24jx	253	8	DNA	DNA	NNP
cord-280549-bsnz24jx	253	9	-	-	HYPH
cord-280549-bsnz24jx	253	10	PK	PK	NNP
cord-280549-bsnz24jx	253	11	pathway	pathway	NN
cord-280549-bsnz24jx	253	12	,	,	,
cord-280549-bsnz24jx	253	13	however	however	RB
cord-280549-bsnz24jx	253	14	,	,	,
cord-280549-bsnz24jx	253	15	impairs	impair	VBZ
cord-280549-bsnz24jx	253	16	cellular	cellular	JJ
cord-280549-bsnz24jx	253	17	response	response	NN
cord-280549-bsnz24jx	253	18	to	to	IN
cord-280549-bsnz24jx	253	19	new	new	JJ
cord-280549-bsnz24jx	253	20	damage	damage	NN
cord-280549-bsnz24jx	254	1	(	(	-LRB-
cord-280549-bsnz24jx	254	2	Durkin	Durkin	NNP
cord-280549-bsnz24jx	254	3	et	et	NNP
cord-280549-bsnz24jx	254	4	al	al	NNP
cord-280549-bsnz24jx	254	5	.	.	NNP
cord-280549-bsnz24jx	254	6	,	,	,
cord-280549-bsnz24jx	254	7	2008	2008	CD
cord-280549-bsnz24jx	254	8	)	)	-RRB-
cord-280549-bsnz24jx	254	9	.	.	.
cord-280549-bsnz24jx	255	1	Thus	thus	RB
cord-280549-bsnz24jx	255	2	,	,	,
cord-280549-bsnz24jx	255	3	through	through	IN
cord-280549-bsnz24jx	255	4	saturating	saturate	VBG
cord-280549-bsnz24jx	255	5	DNA	dna	NN
cord-280549-bsnz24jx	255	6	-	-	HYPH
cord-280549-bsnz24jx	255	7	PK	pk	NN
cord-280549-bsnz24jx	255	8	-	-	HYPH
cord-280549-bsnz24jx	255	9	mediated	mediate	VBN
cord-280549-bsnz24jx	255	10	damage	damage	NN
cord-280549-bsnz24jx	255	11	repair	repair	NN
cord-280549-bsnz24jx	255	12	response	response	NN
cord-280549-bsnz24jx	255	13	,	,	,
cord-280549-bsnz24jx	255	14	Tax	tax	NN
cord-280549-bsnz24jx	255	15	inactivates	inactivate	VBZ
cord-280549-bsnz24jx	255	16	Chk2	Chk2	NNP
cord-280549-bsnz24jx	255	17	.	.	.
cord-280549-bsnz24jx	256	1	Furthermore	furthermore	RB
cord-280549-bsnz24jx	256	2	,	,	,
cord-280549-bsnz24jx	256	3	the	the	DT
cord-280549-bsnz24jx	256	4	delay	delay	NN
cord-280549-bsnz24jx	256	5	and	and	CC
cord-280549-bsnz24jx	256	6	impairment	impairment	NN
cord-280549-bsnz24jx	256	7	of	of	IN
cord-280549-bsnz24jx	256	8	the	the	DT
cord-280549-bsnz24jx	256	9	cellular	cellular	JJ
cord-280549-bsnz24jx	256	10	DNA	dna	NN
cord-280549-bsnz24jx	256	11	damage	damage	NN
cord-280549-bsnz24jx	256	12	response	response	NN
cord-280549-bsnz24jx	256	13	imposed	impose	VBN
cord-280549-bsnz24jx	256	14	by	by	IN
cord-280549-bsnz24jx	256	15	Tax	Tax	NNP
cord-280549-bsnz24jx	256	16	appears	appear	VBZ
cord-280549-bsnz24jx	256	17	to	to	TO
cord-280549-bsnz24jx	256	18	be	be	VB
cord-280549-bsnz24jx	256	19	regulated	regulate	VBN
cord-280549-bsnz24jx	256	20	by	by	IN
cord-280549-bsnz24jx	256	21	molecular	molecular	JJ
cord-280549-bsnz24jx	256	22	sequestration	sequestration	NN
cord-280549-bsnz24jx	256	23	of	of	IN
cord-280549-bsnz24jx	256	24	DNA	dna	NN
cord-280549-bsnz24jx	256	25	-	-	HYPH
cord-280549-bsnz24jx	256	26	PK	PK	NNP
cord-280549-bsnz24jx	256	27	by	by	IN
cord-280549-bsnz24jx	256	28	Tax	tax	NN
cord-280549-bsnz24jx	256	29	through	through	IN
cord-280549-bsnz24jx	256	30	physical	physical	JJ
cord-280549-bsnz24jx	256	31	interaction	interaction	NN
cord-280549-bsnz24jx	256	32	(	(	-LRB-
cord-280549-bsnz24jx	256	33	Durkin	Durkin	NNP
cord-280549-bsnz24jx	256	34	et	et	NNP
cord-280549-bsnz24jx	256	35	al	al	NNP
cord-280549-bsnz24jx	256	36	.	.	NNP
cord-280549-bsnz24jx	256	37	,	,	,
cord-280549-bsnz24jx	256	38	2008	2008	CD
cord-280549-bsnz24jx	256	39	)	)	-RRB-
cord-280549-bsnz24jx	256	40	.	.	.
cord-280549-bsnz24jx	257	1	The	the	DT
cord-280549-bsnz24jx	257	2	nuclear	nuclear	JJ
cord-280549-bsnz24jx	257	3	antigen	antigen	NN
cord-280549-bsnz24jx	257	4	3C	3C	NNP
cord-280549-bsnz24jx	257	5	(	(	-LRB-
cord-280549-bsnz24jx	257	6	EBNA-3C	EBNA-3C	NNP
cord-280549-bsnz24jx	257	7	)	)	-RRB-
cord-280549-bsnz24jx	257	8	of	of	IN
cord-280549-bsnz24jx	257	9	Bevies	Bevies	NNPS
cord-280549-bsnz24jx	257	10	is	be	VBZ
cord-280549-bsnz24jx	257	11	another	another	DT
cord-280549-bsnz24jx	257	12	viral	viral	JJ
cord-280549-bsnz24jx	257	13	protein	protein	NN
cord-280549-bsnz24jx	257	14	that	that	WDT
cord-280549-bsnz24jx	257	15	interacts	interact	VBZ
cord-280549-bsnz24jx	257	16	with	with	IN
cord-280549-bsnz24jx	257	17	Chk2	Chk2	NNP
cord-280549-bsnz24jx	257	18	,	,	,
cord-280549-bsnz24jx	257	19	resulting	result	VBG
cord-280549-bsnz24jx	257	20	in	in	IN
cord-280549-bsnz24jx	257	21	reduced	reduce	VBN
cord-280549-bsnz24jx	257	22	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	257	23	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	257	24	at	at	IN
cord-280549-bsnz24jx	257	25	Ser216	ser216	CD
cord-280549-bsnz24jx	257	26	.	.	.
cord-280549-bsnz24jx	258	1	This	this	DT
cord-280549-bsnz24jx	258	2	Chk2-dependent	Chk2-dependent	NNP
cord-280549-bsnz24jx	258	3	step	step	NN
cord-280549-bsnz24jx	258	4	causes	cause	VBZ
cord-280549-bsnz24jx	258	5	sequestration	sequestration	NN
cord-280549-bsnz24jx	258	6	of	of	IN
cord-280549-bsnz24jx	258	7	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	258	8	in	in	IN
cord-280549-bsnz24jx	258	9	the	the	DT
cord-280549-bsnz24jx	258	10	cytoplasm	cytoplasm	NN
cord-280549-bsnz24jx	258	11	,	,	,
cord-280549-bsnz24jx	258	12	which	which	WDT
cord-280549-bsnz24jx	258	13	prevents	prevent	VBZ
cord-280549-bsnz24jx	258	14	removal	removal	NN
cord-280549-bsnz24jx	258	15	of	of	IN
cord-280549-bsnz24jx	258	16	the	the	DT
cord-280549-bsnz24jx	258	17	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	258	18	phosphates	phosphate	NNS
cord-280549-bsnz24jx	258	19	from	from	IN
cord-280549-bsnz24jx	258	20	CDKs	cdk	NNS
cord-280549-bsnz24jx	258	21	,	,	,
cord-280549-bsnz24jx	258	22	leading	lead	VBG
cord-280549-bsnz24jx	258	23	to	to	IN
cord-280549-bsnz24jx	258	24	EBNA3C	ebna3c	NN
cord-280549-bsnz24jx	258	25	-	-	HYPH
cord-280549-bsnz24jx	258	26	mediated	mediate	VBN
cord-280549-bsnz24jx	258	27	abrogation	abrogation	NN
cord-280549-bsnz24jx	258	28	of	of	IN
cord-280549-bsnz24jx	258	29	the	the	DT
cord-280549-bsnz24jx	258	30	G2	G2	NNP
cord-280549-bsnz24jx	258	31	/	/	SYM
cord-280549-bsnz24jx	258	32	M	M	NNP
cord-280549-bsnz24jx	258	33	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	258	34	and	and	CC
cord-280549-bsnz24jx	258	35	transformation	transformation	NN
cord-280549-bsnz24jx	258	36	in	in	IN
cord-280549-bsnz24jx	258	37	lymphoblastoid	lymphoblastoid	NNP
cord-280549-bsnz24jx	258	38	cell	cell	NN
cord-280549-bsnz24jx	258	39	lines	line	NNS
cord-280549-bsnz24jx	259	1	(	(	-LRB-
cord-280549-bsnz24jx	259	2	Choudhuri	Choudhuri	NNP
cord-280549-bsnz24jx	259	3	et	et	FW
cord-280549-bsnz24jx	259	4	al	al	NNP
cord-280549-bsnz24jx	259	5	.	.	NNP
cord-280549-bsnz24jx	259	6	,	,	,
cord-280549-bsnz24jx	259	7	2007	2007	CD
cord-280549-bsnz24jx	259	8	)	)	-RRB-
cord-280549-bsnz24jx	259	9	.	.	.
cord-280549-bsnz24jx	260	1	The	the	DT
cord-280549-bsnz24jx	260	2	tumor	tumor	NN
cord-280549-bsnz24jx	260	3	suppressor	suppressor	NN
cord-280549-bsnz24jx	260	4	,	,	,
cord-280549-bsnz24jx	260	5	p53	p53	NN
cord-280549-bsnz24jx	260	6	,	,	,
cord-280549-bsnz24jx	260	7	was	be	VBD
cord-280549-bsnz24jx	260	8	first	first	RB
cord-280549-bsnz24jx	260	9	identified	identify	VBN
cord-280549-bsnz24jx	260	10	as	as	IN
cord-280549-bsnz24jx	260	11	a	a	DT
cord-280549-bsnz24jx	260	12	host	host	NN
cord-280549-bsnz24jx	260	13	protein	protein	NN
cord-280549-bsnz24jx	260	14	that	that	WDT
cord-280549-bsnz24jx	260	15	stably	stably	RB
cord-280549-bsnz24jx	260	16	interacts	interact	VBZ
cord-280549-bsnz24jx	260	17	with	with	IN
cord-280549-bsnz24jx	260	18	the	the	DT
cord-280549-bsnz24jx	260	19	L	l	NN
cord-280549-bsnz24jx	260	20	-	-	HYPH
cord-280549-bsnz24jx	260	21	Tag	Tag	NNP
cord-280549-bsnz24jx	260	22	of	of	IN
cord-280549-bsnz24jx	260	23	SV40	SV40	NNP
cord-280549-bsnz24jx	261	1	(	(	-LRB-
cord-280549-bsnz24jx	261	2	Lane	Lane	NNP
cord-280549-bsnz24jx	261	3	and	and	CC
cord-280549-bsnz24jx	261	4	Crawford	Crawford	NNP
cord-280549-bsnz24jx	261	5	,	,	,
cord-280549-bsnz24jx	261	6	1979	1979	CD
cord-280549-bsnz24jx	261	7	;	;	.
cord-280549-bsnz24jx	262	1	Linzer	Linzer	NNP
cord-280549-bsnz24jx	262	2	and	and	CC
cord-280549-bsnz24jx	262	3	Levine	Levine	NNP
cord-280549-bsnz24jx	262	4	,	,	,
cord-280549-bsnz24jx	262	5	1979	1979	CD
cord-280549-bsnz24jx	262	6	;	;	:
cord-280549-bsnz24jx	262	7	Tan	Tan	NNP
cord-280549-bsnz24jx	262	8	et	et	FW
cord-280549-bsnz24jx	262	9	al	al	NNP
cord-280549-bsnz24jx	262	10	.	.	NNP
cord-280549-bsnz24jx	262	11	,	,	,
cord-280549-bsnz24jx	262	12	1986	1986	CD
cord-280549-bsnz24jx	262	13	)	)	-RRB-
cord-280549-bsnz24jx	262	14	.	.	.
cord-280549-bsnz24jx	263	1	The	the	DT
cord-280549-bsnz24jx	263	2	use	use	NN
cord-280549-bsnz24jx	263	3	of	of	IN
cord-280549-bsnz24jx	263	4	chloramphenicol	chloramphenicol	NN
cord-280549-bsnz24jx	263	5	(	(	-LRB-
cord-280549-bsnz24jx	263	6	CAT	CAT	NNP
cord-280549-bsnz24jx	263	7	)	)	-RRB-
cord-280549-bsnz24jx	263	8	assay	assay	NN
cord-280549-bsnz24jx	263	9	demonstrated	demonstrate	VBD
cord-280549-bsnz24jx	263	10	that	that	IN
cord-280549-bsnz24jx	263	11	L	l	NN
cord-280549-bsnz24jx	263	12	-	-	HYPH
cord-280549-bsnz24jx	263	13	Tag	Tag	NNP
cord-280549-bsnz24jx	263	14	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	263	15	the	the	DT
cord-280549-bsnz24jx	263	16	transactivation	transactivation	NN
cord-280549-bsnz24jx	263	17	function	function	NN
cord-280549-bsnz24jx	263	18	of	of	IN
cord-280549-bsnz24jx	263	19	p53	p53	NN
cord-280549-bsnz24jx	263	20	,	,	,
cord-280549-bsnz24jx	263	21	which	which	WDT
cord-280549-bsnz24jx	263	22	is	be	VBZ
cord-280549-bsnz24jx	263	23	mediated	mediate	VBN
cord-280549-bsnz24jx	263	24	through	through	IN
cord-280549-bsnz24jx	263	25	physical	physical	JJ
cord-280549-bsnz24jx	263	26	interaction	interaction	NN
cord-280549-bsnz24jx	263	27	as	as	IN
cord-280549-bsnz24jx	263	28	L	l	NN
cord-280549-bsnz24jx	263	29	-	-	HYPH
cord-280549-bsnz24jx	263	30	Tag	tag	NN
cord-280549-bsnz24jx	263	31	mutants	mutant	NNS
cord-280549-bsnz24jx	263	32	deficient	deficient	JJ
cord-280549-bsnz24jx	263	33	in	in	IN
cord-280549-bsnz24jx	263	34	p53	p53	NN
cord-280549-bsnz24jx	263	35	binding	binding	NN
cord-280549-bsnz24jx	263	36	fail	fail	VBP
cord-280549-bsnz24jx	263	37	to	to	TO
cord-280549-bsnz24jx	263	38	prevent	prevent	VB
cord-280549-bsnz24jx	263	39	downstream	downstream	JJ
cord-280549-bsnz24jx	263	40	activation	activation	NN
cord-280549-bsnz24jx	263	41	of	of	IN
cord-280549-bsnz24jx	263	42	gene	gene	NN
cord-280549-bsnz24jx	263	43	expression	expression	NN
cord-280549-bsnz24jx	264	1	(	(	-LRB-
cord-280549-bsnz24jx	264	2	Mietz	Mietz	NNP
cord-280549-bsnz24jx	264	3	et	et	NNP
cord-280549-bsnz24jx	264	4	al	al	NNP
cord-280549-bsnz24jx	264	5	.	.	NNP
cord-280549-bsnz24jx	264	6	,	,	,
cord-280549-bsnz24jx	264	7	1992	1992	CD
cord-280549-bsnz24jx	264	8	)	)	-RRB-
cord-280549-bsnz24jx	264	9	.	.	.
cord-280549-bsnz24jx	265	1	Similarly	similarly	RB
cord-280549-bsnz24jx	265	2	,	,	,
cord-280549-bsnz24jx	265	3	complex	complex	JJ
cord-280549-bsnz24jx	265	4	formation	formation	NN
cord-280549-bsnz24jx	265	5	between	between	IN
cord-280549-bsnz24jx	265	6	HPV	HPV	NNP
cord-280549-bsnz24jx	265	7	E6	E6	NNP
cord-280549-bsnz24jx	265	8	,	,	,
cord-280549-bsnz24jx	265	9	limited	limit	VBN
cord-280549-bsnz24jx	265	10	only	only	RB
cord-280549-bsnz24jx	265	11	to	to	IN
cord-280549-bsnz24jx	265	12	the	the	DT
cord-280549-bsnz24jx	265	13	oncogenic	oncogenic	JJ
cord-280549-bsnz24jx	265	14	HPV	hpv	NN
cord-280549-bsnz24jx	265	15	types	type	NNS
cord-280549-bsnz24jx	266	1	(	(	-LRB-
cord-280549-bsnz24jx	266	2	Werness	Werness	NNP
cord-280549-bsnz24jx	266	3	et	et	NNP
cord-280549-bsnz24jx	266	4	al	al	NNP
cord-280549-bsnz24jx	266	5	.	.	NNP
cord-280549-bsnz24jx	266	6	,	,	,
cord-280549-bsnz24jx	266	7	1990	1990	CD
cord-280549-bsnz24jx	266	8	;	;	:
cord-280549-bsnz24jx	266	9	Mietz	Mietz	NNP
cord-280549-bsnz24jx	266	10	et	et	NNP
cord-280549-bsnz24jx	266	11	al	al	NNP
cord-280549-bsnz24jx	266	12	.	.	NNP
cord-280549-bsnz24jx	266	13	,	,	,
cord-280549-bsnz24jx	266	14	1992	1992	CD
cord-280549-bsnz24jx	266	15	)	)	-RRB-
cord-280549-bsnz24jx	266	16	,	,	,
cord-280549-bsnz24jx	266	17	and	and	CC
cord-280549-bsnz24jx	266	18	p53	p53	NN
cord-280549-bsnz24jx	266	19	leads	lead	NNS
cord-280549-bsnz24jx	266	20	to	to	IN
cord-280549-bsnz24jx	266	21	a	a	DT
cord-280549-bsnz24jx	266	22	drastic	drastic	JJ
cord-280549-bsnz24jx	266	23	reduction	reduction	NN
cord-280549-bsnz24jx	266	24	(	(	-LRB-
cord-280549-bsnz24jx	266	25	more	more	JJR
cord-280549-bsnz24jx	266	26	than	than	IN
cord-280549-bsnz24jx	266	27	80	80	CD
cord-280549-bsnz24jx	266	28	%	%	NN
cord-280549-bsnz24jx	266	29	)	)	-RRB-
cord-280549-bsnz24jx	266	30	in	in	IN
cord-280549-bsnz24jx	266	31	the	the	DT
cord-280549-bsnz24jx	266	32	level	level	NN
cord-280549-bsnz24jx	266	33	of	of	IN
cord-280549-bsnz24jx	266	34	p53-mediated	p53-mediated	JJ
cord-280549-bsnz24jx	266	35	transactivation	transactivation	NN
cord-280549-bsnz24jx	266	36	in	in	IN
cord-280549-bsnz24jx	266	37	CAT	cat	NN
cord-280549-bsnz24jx	266	38	assay	assay	NN
cord-280549-bsnz24jx	266	39	system	system	NN
cord-280549-bsnz24jx	266	40	.	.	.
cord-280549-bsnz24jx	267	1	HCMV	HCMV	NNP
cord-280549-bsnz24jx	267	2	IE2	IE2	NNP
cord-280549-bsnz24jx	267	3	-	-	HYPH
cord-280549-bsnz24jx	267	4	86	86	CD
cord-280549-bsnz24jx	267	5	is	be	VBZ
cord-280549-bsnz24jx	267	6	able	able	JJ
cord-280549-bsnz24jx	267	7	to	to	TO
cord-280549-bsnz24jx	267	8	repress	repress	VB
cord-280549-bsnz24jx	267	9	p53	p53	NN
cord-280549-bsnz24jx	267	10	function	function	NN
cord-280549-bsnz24jx	267	11	via	via	IN
cord-280549-bsnz24jx	267	12	physical	physical	JJ
cord-280549-bsnz24jx	267	13	interaction	interaction	NN
cord-280549-bsnz24jx	267	14	and	and	CC
cord-280549-bsnz24jx	267	15	this	this	DT
cord-280549-bsnz24jx	267	16	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	267	17	effect	effect	NN
cord-280549-bsnz24jx	267	18	requires	require	VBZ
cord-280549-bsnz24jx	267	19	two	two	CD
cord-280549-bsnz24jx	267	20	functional	functional	JJ
cord-280549-bsnz24jx	267	21	domains	domain	NNS
cord-280549-bsnz24jx	267	22	on	on	IN
cord-280549-bsnz24jx	267	23	IE2	ie2	NN
cord-280549-bsnz24jx	267	24	-	-	HYPH
cord-280549-bsnz24jx	267	25	86	86	CD
cord-280549-bsnz24jx	268	1	(	(	-LRB-
cord-280549-bsnz24jx	268	2	Speir	Speir	NNP
cord-280549-bsnz24jx	268	3	et	et	NNP
cord-280549-bsnz24jx	268	4	al	al	NNP
cord-280549-bsnz24jx	268	5	.	.	NNP
cord-280549-bsnz24jx	268	6	,	,	,
cord-280549-bsnz24jx	268	7	1994	1994	CD
cord-280549-bsnz24jx	268	8	;	;	:
cord-280549-bsnz24jx	268	9	Tsai	Tsai	NNP
cord-280549-bsnz24jx	268	10	et	et	NNP
cord-280549-bsnz24jx	268	11	al	al	NNP
cord-280549-bsnz24jx	268	12	.	.	NNP
cord-280549-bsnz24jx	268	13	,	,	,
cord-280549-bsnz24jx	268	14	1996	1996	CD
cord-280549-bsnz24jx	268	15	)	)	-RRB-
cord-280549-bsnz24jx	268	16	.	.	.
cord-280549-bsnz24jx	269	1	Tsai	Tsai	NNP
cord-280549-bsnz24jx	269	2	et	et	NNP
cord-280549-bsnz24jx	269	3	al	al	NNP
cord-280549-bsnz24jx	269	4	.	.	NNP
cord-280549-bsnz24jx	269	5	showed	show	VBD
cord-280549-bsnz24jx	269	6	that	that	IN
cord-280549-bsnz24jx	269	7	the	the	DT
cord-280549-bsnz24jx	269	8	N	n	CD
cord-280549-bsnz24jx	269	9	-	-	HYPH
cord-280549-bsnz24jx	269	10	terminus	terminus	NN
cord-280549-bsnz24jx	269	11	of	of	IN
cord-280549-bsnz24jx	269	12	IE2	IE2	NNP
cord-280549-bsnz24jx	269	13	-	-	HYPH
cord-280549-bsnz24jx	269	14	86	86	CD
cord-280549-bsnz24jx	269	15	was	be	VBD
cord-280549-bsnz24jx	269	16	necessary	necessary	JJ
cord-280549-bsnz24jx	269	17	for	for	IN
cord-280549-bsnz24jx	269	18	p53-binding	p53-binde	VBG
cord-280549-bsnz24jx	269	19	while	while	IN
cord-280549-bsnz24jx	269	20	the	the	DT
cord-280549-bsnz24jx	269	21	C	c	NN
cord-280549-bsnz24jx	269	22	-	-	HYPH
cord-280549-bsnz24jx	269	23	terminal	terminal	NN
cord-280549-bsnz24jx	269	24	domain	domain	NN
cord-280549-bsnz24jx	269	25	was	be	VBD
cord-280549-bsnz24jx	269	26	needed	need	VBN
cord-280549-bsnz24jx	269	27	to	to	TO
cord-280549-bsnz24jx	269	28	inhibit	inhibit	VB
cord-280549-bsnz24jx	269	29	p53-mediated	p53-mediated	JJ
cord-280549-bsnz24jx	269	30	transactivation	transactivation	NN
cord-280549-bsnz24jx	269	31	,	,	,
cord-280549-bsnz24jx	269	32	suggesting	suggest	VBG
cord-280549-bsnz24jx	269	33	that	that	IN
cord-280549-bsnz24jx	269	34	IE2	IE2	NNP
cord-280549-bsnz24jx	269	35	-	-	HYPH
cord-280549-bsnz24jx	269	36	86	86	CD
cord-280549-bsnz24jx	269	37	is	be	VBZ
cord-280549-bsnz24jx	269	38	recruited	recruit	VBN
cord-280549-bsnz24jx	269	39	by	by	IN
cord-280549-bsnz24jx	269	40	protein	protein	NN
cord-280549-bsnz24jx	269	41	interaction	interaction	NN
cord-280549-bsnz24jx	269	42	to	to	TO
cord-280549-bsnz24jx	269	43	target	target	VB
cord-280549-bsnz24jx	269	44	p53	p53	NN
cord-280549-bsnz24jx	269	45	and	and	CC
cord-280549-bsnz24jx	269	46	exert	exert	VB
cord-280549-bsnz24jx	269	47	its	-PRON-	PRP$
cord-280549-bsnz24jx	269	48	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	269	49	effect	effect	NN
cord-280549-bsnz24jx	269	50	(	(	-LRB-
cord-280549-bsnz24jx	269	51	Tsai	Tsai	NNP
cord-280549-bsnz24jx	269	52	et	et	NNP
cord-280549-bsnz24jx	269	53	al	al	NNP
cord-280549-bsnz24jx	269	54	.	.	NNP
cord-280549-bsnz24jx	269	55	,	,	,
cord-280549-bsnz24jx	269	56	1996	1996	CD
cord-280549-bsnz24jx	269	57	)	)	-RRB-
cord-280549-bsnz24jx	269	58	.	.	.
cord-280549-bsnz24jx	270	1	Another	another	DT
cord-280549-bsnz24jx	270	2	HCMV	HCMV	NNP
cord-280549-bsnz24jx	270	3	protein	protein	NN
cord-280549-bsnz24jx	270	4	,	,	,
cord-280549-bsnz24jx	270	5	which	which	WDT
cord-280549-bsnz24jx	270	6	alters	alter	VBZ
cord-280549-bsnz24jx	270	7	p53-orchestrated	p53-orchestrated	JJ
cord-280549-bsnz24jx	270	8	cellular	cellular	JJ
cord-280549-bsnz24jx	270	9	regulatory	regulatory	JJ
cord-280549-bsnz24jx	270	10	mechanisms	mechanism	NNS
cord-280549-bsnz24jx	270	11	,	,	,
cord-280549-bsnz24jx	270	12	leading	lead	VBG
cord-280549-bsnz24jx	270	13	to	to	IN
cord-280549-bsnz24jx	270	14	tumorigenic	tumorigenic	JJ
cord-280549-bsnz24jx	270	15	transformation	transformation	NN
cord-280549-bsnz24jx	270	16	in	in	IN
cord-280549-bsnz24jx	270	17	rodent	rodent	NN
cord-280549-bsnz24jx	270	18	cells	cell	NNS
cord-280549-bsnz24jx	270	19	,	,	,
cord-280549-bsnz24jx	270	20	is	be	VBZ
cord-280549-bsnz24jx	270	21	the	the	DT
cord-280549-bsnz24jx	270	22	morphological	morphological	JJ
cord-280549-bsnz24jx	270	23	transforming	transform	VBG
cord-280549-bsnz24jx	270	24	region	region	NN
cord-280549-bsnz24jx	270	25	II	II	NNP
cord-280549-bsnz24jx	270	26	(	(	-LRB-
cord-280549-bsnz24jx	270	27	mtrII	mtrii	NN
cord-280549-bsnz24jx	270	28	)	)	-RRB-
cord-280549-bsnz24jx	271	1	(	(	-LRB-
cord-280549-bsnz24jx	271	2	Thompson	Thompson	NNP
cord-280549-bsnz24jx	271	3	et	et	NNP
cord-280549-bsnz24jx	271	4	al	al	NNP
cord-280549-bsnz24jx	271	5	.	.	.
cord-280549-bsnz24jx	272	1	,	,	,
cord-280549-bsnz24jx	272	2	1994	1994	CD
cord-280549-bsnz24jx	272	3	;	;	:
cord-280549-bsnz24jx	272	4	Muralidhar	Muralidhar	NNP
cord-280549-bsnz24jx	272	5	et	et	NNP
cord-280549-bsnz24jx	272	6	al	al	NNP
cord-280549-bsnz24jx	272	7	.	.	NNP
cord-280549-bsnz24jx	272	8	,	,	,
cord-280549-bsnz24jx	272	9	1996	1996	CD
cord-280549-bsnz24jx	272	10	)	)	-RRB-
cord-280549-bsnz24jx	272	11	.	.	.
cord-280549-bsnz24jx	273	1	It	-PRON-	PRP
cord-280549-bsnz24jx	273	2	was	be	VBD
cord-280549-bsnz24jx	273	3	reported	report	VBN
cord-280549-bsnz24jx	273	4	that	that	IN
cord-280549-bsnz24jx	273	5	the	the	DT
cord-280549-bsnz24jx	273	6	first	first	JJ
cord-280549-bsnz24jx	273	7	49	49	CD
cord-280549-bsnz24jx	273	8	amino	amino	JJ
cord-280549-bsnz24jx	273	9	acids	acid	NNS
cord-280549-bsnz24jx	273	10	of	of	IN
cord-280549-bsnz24jx	273	11	mtrII	mtrII	NNP
cord-280549-bsnz24jx	273	12	mediate	mediate	VB
cord-280549-bsnz24jx	273	13	its	-PRON-	PRP$
cord-280549-bsnz24jx	273	14	binding	binding	NN
cord-280549-bsnz24jx	273	15	to	to	IN
cord-280549-bsnz24jx	273	16	p53	p53	NN
cord-280549-bsnz24jx	273	17	and	and	CC
cord-280549-bsnz24jx	273	18	are	be	VBP
cord-280549-bsnz24jx	273	19	sufficient	sufficient	JJ
cord-280549-bsnz24jx	273	20	to	to	TO
cord-280549-bsnz24jx	273	21	repress	repress	VB
cord-280549-bsnz24jx	273	22	p53-activated	p53-activated	JJ
cord-280549-bsnz24jx	273	23	transcription	transcription	NN
cord-280549-bsnz24jx	274	1	(	(	-LRB-
cord-280549-bsnz24jx	274	2	Muralidhar	Muralidhar	NNP
cord-280549-bsnz24jx	274	3	et	et	NNP
cord-280549-bsnz24jx	274	4	al	al	NNP
cord-280549-bsnz24jx	274	5	.	.	NNP
cord-280549-bsnz24jx	274	6	,	,	,
cord-280549-bsnz24jx	274	7	1996	1996	CD
cord-280549-bsnz24jx	274	8	)	)	-RRB-
cord-280549-bsnz24jx	274	9	.	.	.
cord-280549-bsnz24jx	275	1	Binding	bind	VBG
cord-280549-bsnz24jx	275	2	of	of	IN
cord-280549-bsnz24jx	275	3	the	the	DT
cord-280549-bsnz24jx	275	4	nonstructural	nonstructural	JJ
cord-280549-bsnz24jx	275	5	protein	protein	NNP
cord-280549-bsnz24jx	275	6	3	3	CD
cord-280549-bsnz24jx	275	7	(	(	-LRB-
cord-280549-bsnz24jx	275	8	NS3	ns3	RB
cord-280549-bsnz24jx	275	9	)	)	-RRB-
cord-280549-bsnz24jx	275	10	of	of	IN
cord-280549-bsnz24jx	275	11	HCV	HCV	NNP
cord-280549-bsnz24jx	275	12	to	to	IN
cord-280549-bsnz24jx	275	13	p53	p53	NN
cord-280549-bsnz24jx	275	14	has	have	VBZ
cord-280549-bsnz24jx	275	15	been	be	VBN
cord-280549-bsnz24jx	275	16	located	locate	VBN
cord-280549-bsnz24jx	275	17	to	to	IN
cord-280549-bsnz24jx	275	18	the	the	DT
cord-280549-bsnz24jx	275	19	C	C	NNP
cord-280549-bsnz24jx	275	20	-	-	HYPH
cord-280549-bsnz24jx	275	21	terminus	terminus	NN
cord-280549-bsnz24jx	275	22	,	,	,
cord-280549-bsnz24jx	275	23	a	a	DT
cord-280549-bsnz24jx	275	24	region	region	NN
cord-280549-bsnz24jx	275	25	that	that	WDT
cord-280549-bsnz24jx	275	26	also	also	RB
cord-280549-bsnz24jx	275	27	contains	contain	VBZ
cord-280549-bsnz24jx	275	28	the	the	DT
cord-280549-bsnz24jx	275	29	oligomerization	oligomerization	NN
cord-280549-bsnz24jx	275	30	domains	domain	NNS
cord-280549-bsnz24jx	275	31	required	require	VBN
cord-280549-bsnz24jx	275	32	for	for	IN
cord-280549-bsnz24jx	275	33	the	the	DT
cord-280549-bsnz24jx	275	34	latter	latter	JJ
cord-280549-bsnz24jx	275	35	to	to	TO
cord-280549-bsnz24jx	275	36	form	form	VB
cord-280549-bsnz24jx	275	37	the	the	DT
cord-280549-bsnz24jx	275	38	bioactive	bioactive	JJ
cord-280549-bsnz24jx	275	39	homo	homo	NN
cord-280549-bsnz24jx	275	40	-	-	HYPH
cord-280549-bsnz24jx	275	41	tetramer	tetramer	NN
cord-280549-bsnz24jx	275	42	(	(	-LRB-
cord-280549-bsnz24jx	275	43	Levine	Levine	NNP
cord-280549-bsnz24jx	275	44	,	,	,
cord-280549-bsnz24jx	275	45	1997	1997	CD
cord-280549-bsnz24jx	275	46	;	;	:
cord-280549-bsnz24jx	275	47	Ishido	Ishido	NNP
cord-280549-bsnz24jx	275	48	and	and	CC
cord-280549-bsnz24jx	275	49	Hotta	Hotta	NNP
cord-280549-bsnz24jx	275	50	,	,	,
cord-280549-bsnz24jx	275	51	1998	1998	CD
cord-280549-bsnz24jx	275	52	)	)	-RRB-
cord-280549-bsnz24jx	275	53	.	.	.
cord-280549-bsnz24jx	276	1	It	-PRON-	PRP
cord-280549-bsnz24jx	276	2	has	have	VBZ
cord-280549-bsnz24jx	276	3	been	be	VBN
cord-280549-bsnz24jx	276	4	proposed	propose	VBN
cord-280549-bsnz24jx	276	5	that	that	IN
cord-280549-bsnz24jx	276	6	binding	binding	NN
cord-280549-bsnz24jx	276	7	of	of	IN
cord-280549-bsnz24jx	276	8	NS3	ns3	RB
cord-280549-bsnz24jx	276	9	to	to	TO
cord-280549-bsnz24jx	276	10	p53	p53	VB
cord-280549-bsnz24jx	276	11	interferes	interfere	VBZ
cord-280549-bsnz24jx	276	12	with	with	IN
cord-280549-bsnz24jx	276	13	the	the	DT
cord-280549-bsnz24jx	276	14	formation	formation	NN
cord-280549-bsnz24jx	276	15	of	of	IN
cord-280549-bsnz24jx	276	16	p53	p53	NN
cord-280549-bsnz24jx	276	17	tetramer	tetramer	NN
cord-280549-bsnz24jx	276	18	,	,	,
cord-280549-bsnz24jx	276	19	which	which	WDT
cord-280549-bsnz24jx	276	20	is	be	VBZ
cord-280549-bsnz24jx	276	21	most	most	RBS
cord-280549-bsnz24jx	276	22	effective	effective	JJ
cord-280549-bsnz24jx	276	23	in	in	IN
cord-280549-bsnz24jx	276	24	transactivating	transactivate	VBG
cord-280549-bsnz24jx	276	25	its	-PRON-	PRP$
cord-280549-bsnz24jx	276	26	target	target	NN
cord-280549-bsnz24jx	276	27	genes	gene	NNS
cord-280549-bsnz24jx	276	28	,	,	,
cord-280549-bsnz24jx	276	29	leading	lead	VBG
cord-280549-bsnz24jx	276	30	to	to	IN
cord-280549-bsnz24jx	276	31	impaired	impair	VBN
cord-280549-bsnz24jx	276	32	p53-dependent	p53-dependent	CD
cord-280549-bsnz24jx	276	33	transcriptional	transcriptional	JJ
cord-280549-bsnz24jx	276	34	activation	activation	NN
cord-280549-bsnz24jx	276	35	(	(	-LRB-
cord-280549-bsnz24jx	276	36	Deng	Deng	NNP
cord-280549-bsnz24jx	276	37	et	et	FW
cord-280549-bsnz24jx	276	38	al	al	NNP
cord-280549-bsnz24jx	276	39	.	.	NNP
cord-280549-bsnz24jx	276	40	,	,	,
cord-280549-bsnz24jx	276	41	2006	2006	CD
cord-280549-bsnz24jx	276	42	)	)	-RRB-
cord-280549-bsnz24jx	276	43	.	.	.
cord-280549-bsnz24jx	277	1	Interestingly	interestingly	RB
cord-280549-bsnz24jx	277	2	,	,	,
cord-280549-bsnz24jx	277	3	other	other	JJ
cord-280549-bsnz24jx	277	4	than	than	IN
cord-280549-bsnz24jx	277	5	binding	bind	VBG
cord-280549-bsnz24jx	277	6	to	to	IN
cord-280549-bsnz24jx	277	7	p53	p53	NN
cord-280549-bsnz24jx	277	8	itself	-PRON-	PRP
cord-280549-bsnz24jx	277	9	,	,	,
cord-280549-bsnz24jx	277	10	adenovirus	adenovirus	NN
cord-280549-bsnz24jx	277	11	E1A	e1a	NN
cord-280549-bsnz24jx	277	12	targets	target	NNS
cord-280549-bsnz24jx	277	13	p53-mediated	p53-mediated	JJ
cord-280549-bsnz24jx	277	14	transcription	transcription	NN
cord-280549-bsnz24jx	277	15	through	through	IN
cord-280549-bsnz24jx	277	16	interacting	interact	VBG
cord-280549-bsnz24jx	277	17	with	with	IN
cord-280549-bsnz24jx	277	18	the	the	DT
cord-280549-bsnz24jx	277	19	transcriptional	transcriptional	JJ
cord-280549-bsnz24jx	277	20	coactivators	coactivators	NNP
cord-280549-bsnz24jx	277	21	p300	p300	NNP
cord-280549-bsnz24jx	277	22	and	and	CC
cord-280549-bsnz24jx	277	23	CREB	CREB	NNP
cord-280549-bsnz24jx	277	24	-	-	HYPH
cord-280549-bsnz24jx	277	25	binding	bind	VBG
cord-280549-bsnz24jx	277	26	protein	protein	NN
cord-280549-bsnz24jx	277	27	(	(	-LRB-
cord-280549-bsnz24jx	277	28	CBP	CBP	NNP
cord-280549-bsnz24jx	277	29	)	)	-RRB-
cord-280549-bsnz24jx	277	30	of	of	IN
cord-280549-bsnz24jx	277	31	p53	p53	NN
cord-280549-bsnz24jx	277	32	(	(	-LRB-
cord-280549-bsnz24jx	277	33	Somasundaram	Somasundaram	NNP
cord-280549-bsnz24jx	277	34	and	and	CC
cord-280549-bsnz24jx	277	35	El	El	NNP
cord-280549-bsnz24jx	277	36	-	-	HYPH
cord-280549-bsnz24jx	277	37	Deiry	Deiry	NNP
cord-280549-bsnz24jx	277	38	,	,	,
cord-280549-bsnz24jx	277	39	1997	1997	CD
cord-280549-bsnz24jx	277	40	)	)	-RRB-
cord-280549-bsnz24jx	277	41	.	.	.
cord-280549-bsnz24jx	278	1	As	as	IN
cord-280549-bsnz24jx	278	2	a	a	DT
cord-280549-bsnz24jx	278	3	result	result	NN
cord-280549-bsnz24jx	278	4	,	,	,
cord-280549-bsnz24jx	278	5	E1A	E1A	NNP
cord-280549-bsnz24jx	278	6	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	278	7	the	the	DT
cord-280549-bsnz24jx	278	8	activation	activation	NN
cord-280549-bsnz24jx	278	9	of	of	IN
cord-280549-bsnz24jx	278	10	p21	p21	NN
cord-280549-bsnz24jx	278	11	WAF1	WAF1	NNP
cord-280549-bsnz24jx	278	12	/	/	SYM
cord-280549-bsnz24jx	278	13	CIP1	CIP1	NNP
cord-280549-bsnz24jx	278	14	,	,	,
cord-280549-bsnz24jx	278	15	abolishing	abolish	VBG
cord-280549-bsnz24jx	278	16	p53-dependent	p53-dependent	NN
cord-280549-bsnz24jx	278	17	cell	cell	NN
cord-280549-bsnz24jx	278	18	cycle	cycle	NN
cord-280549-bsnz24jx	278	19	arrest	arrest	NN
cord-280549-bsnz24jx	278	20	.	.	.
cord-280549-bsnz24jx	279	1	An	an	DT
cord-280549-bsnz24jx	279	2	interaction	interaction	NN
cord-280549-bsnz24jx	279	3	between	between	IN
cord-280549-bsnz24jx	279	4	the	the	DT
cord-280549-bsnz24jx	279	5	transactivator	transactivator	NN
cord-280549-bsnz24jx	279	6	of	of	IN
cord-280549-bsnz24jx	279	7	transcription	transcription	NN
cord-280549-bsnz24jx	279	8	(	(	-LRB-
cord-280549-bsnz24jx	279	9	Tat	tat	NN
cord-280549-bsnz24jx	279	10	)	)	-RRB-
cord-280549-bsnz24jx	279	11	of	of	IN
cord-280549-bsnz24jx	279	12	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	279	13	and	and	CC
cord-280549-bsnz24jx	279	14	p53	p53	NN
cord-280549-bsnz24jx	279	15	was	be	VBD
cord-280549-bsnz24jx	279	16	correlated	correlate	VBN
cord-280549-bsnz24jx	279	17	to	to	IN
cord-280549-bsnz24jx	279	18	the	the	DT
cord-280549-bsnz24jx	279	19	development	development	NN
cord-280549-bsnz24jx	279	20	of	of	IN
cord-280549-bsnz24jx	279	21	acquired	acquire	VBN
cord-280549-bsnz24jx	279	22	immune	immune	JJ
cord-280549-bsnz24jx	279	23	deficiency	deficiency	NN
cord-280549-bsnz24jx	279	24	syndrome	syndrome	NN
cord-280549-bsnz24jx	279	25	(	(	-LRB-
cord-280549-bsnz24jx	279	26	AIDS)-related	aids)-related	JJ
cord-280549-bsnz24jx	279	27	malignancies	malignancy	NNS
cord-280549-bsnz24jx	279	28	.	.	.
cord-280549-bsnz24jx	280	1	Thus	thus	RB
cord-280549-bsnz24jx	280	2	,	,	,
cord-280549-bsnz24jx	280	3	Clark	Clark	NNP
cord-280549-bsnz24jx	280	4	et	et	NNP
cord-280549-bsnz24jx	280	5	al	al	NNP
cord-280549-bsnz24jx	280	6	.	.	NNP
cord-280549-bsnz24jx	280	7	found	find	VBD
cord-280549-bsnz24jx	280	8	that	that	IN
cord-280549-bsnz24jx	280	9	the	the	DT
cord-280549-bsnz24jx	280	10	presence	presence	NN
cord-280549-bsnz24jx	280	11	of	of	IN
cord-280549-bsnz24jx	280	12	Tat	Tat	NNP
cord-280549-bsnz24jx	280	13	almost	almost	RB
cord-280549-bsnz24jx	280	14	completely	completely	RB
cord-280549-bsnz24jx	280	15	abolished	abolish	VBD
cord-280549-bsnz24jx	280	16	p53mediated	p53mediated	JJ
cord-280549-bsnz24jx	280	17	activation	activation	NN
cord-280549-bsnz24jx	280	18	,	,	,
cord-280549-bsnz24jx	280	19	leading	lead	VBG
cord-280549-bsnz24jx	280	20	to	to	IN
cord-280549-bsnz24jx	280	21	reduced	reduced	JJ
cord-280549-bsnz24jx	280	22	levels	level	NNS
cord-280549-bsnz24jx	280	23	of	of	IN
cord-280549-bsnz24jx	280	24	p21	p21	NN
cord-280549-bsnz24jx	280	25	CIP1	CIP1	NNP
cord-280549-bsnz24jx	280	26	/	/	SYM
cord-280549-bsnz24jx	280	27	WAF1	WAF1	NNP
cord-280549-bsnz24jx	280	28	and	and	CC
cord-280549-bsnz24jx	280	29	the	the	DT
cord-280549-bsnz24jx	280	30	loss	loss	NN
cord-280549-bsnz24jx	280	31	of	of	IN
cord-280549-bsnz24jx	280	32	G1	G1	NNP
cord-280549-bsnz24jx	280	33	/	/	SYM
cord-280549-bsnz24jx	280	34	S	S	NNP
cord-280549-bsnz24jx	280	35	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	280	36	(	(	-LRB-
cord-280549-bsnz24jx	280	37	Clark	Clark	NNP
cord-280549-bsnz24jx	280	38	et	et	NNP
cord-280549-bsnz24jx	280	39	al	al	NNP
cord-280549-bsnz24jx	280	40	.	.	NNP
cord-280549-bsnz24jx	280	41	,	,	,
cord-280549-bsnz24jx	280	42	2000	2000	CD
cord-280549-bsnz24jx	280	43	)	)	-RRB-
cord-280549-bsnz24jx	280	44	.	.	.
cord-280549-bsnz24jx	281	1	However	however	RB
cord-280549-bsnz24jx	281	2	,	,	,
cord-280549-bsnz24jx	281	3	it	-PRON-	PRP
cord-280549-bsnz24jx	281	4	remains	remain	VBZ
cord-280549-bsnz24jx	281	5	to	to	TO
cord-280549-bsnz24jx	281	6	be	be	VB
cord-280549-bsnz24jx	281	7	addressed	address	VBN
cord-280549-bsnz24jx	281	8	whether	whether	IN
cord-280549-bsnz24jx	281	9	a	a	DT
cord-280549-bsnz24jx	281	10	causal	causal	JJ
cord-280549-bsnz24jx	281	11	relationship	relationship	NN
cord-280549-bsnz24jx	281	12	exists	exist	VBZ
cord-280549-bsnz24jx	281	13	between	between	IN
cord-280549-bsnz24jx	281	14	Tat	tat	NN
cord-280549-bsnz24jx	281	15	-	-	HYPH
cord-280549-bsnz24jx	281	16	p53	p53	NN
cord-280549-bsnz24jx	281	17	interaction	interaction	NN
cord-280549-bsnz24jx	281	18	and	and	CC
cord-280549-bsnz24jx	281	19	the	the	DT
cord-280549-bsnz24jx	281	20	repression	repression	NN
cord-280549-bsnz24jx	281	21	of	of	IN
cord-280549-bsnz24jx	281	22	p53	p53	NN
cord-280549-bsnz24jx	281	23	function	function	NN
cord-280549-bsnz24jx	281	24	,	,	,
cord-280549-bsnz24jx	281	25	which	which	WDT
cord-280549-bsnz24jx	281	26	will	will	MD
cord-280549-bsnz24jx	281	27	require	require	VB
cord-280549-bsnz24jx	281	28	the	the	DT
cord-280549-bsnz24jx	281	29	use	use	NN
cord-280549-bsnz24jx	281	30	of	of	IN
cord-280549-bsnz24jx	281	31	p53	p53	NN
cord-280549-bsnz24jx	281	32	binding	binding	NN
cord-280549-bsnz24jx	281	33	-	-	HYPH
cord-280549-bsnz24jx	281	34	deficient	deficient	JJ
cord-280549-bsnz24jx	281	35	Tat	tat	NN
cord-280549-bsnz24jx	281	36	.	.	.
cord-280549-bsnz24jx	282	1	Interactions	interaction	NNS
cord-280549-bsnz24jx	282	2	of	of	IN
cord-280549-bsnz24jx	282	3	viral	viral	JJ
cord-280549-bsnz24jx	282	4	component	component	NN
cord-280549-bsnz24jx	282	5	with	with	IN
cord-280549-bsnz24jx	282	6	other	other	JJ
cord-280549-bsnz24jx	282	7	cell	cell	NN
cord-280549-bsnz24jx	282	8	-	-	HYPH
cord-280549-bsnz24jx	282	9	cycle	cycle	NN
cord-280549-bsnz24jx	282	10	regulators	regulator	NNS
cord-280549-bsnz24jx	282	11	have	have	VBP
cord-280549-bsnz24jx	282	12	been	be	VBN
cord-280549-bsnz24jx	282	13	reported	report	VBN
cord-280549-bsnz24jx	282	14	for	for	IN
cord-280549-bsnz24jx	282	15	several	several	JJ
cord-280549-bsnz24jx	282	16	viruses	virus	NNS
cord-280549-bsnz24jx	282	17	.	.	.
cord-280549-bsnz24jx	283	1	For	for	IN
cord-280549-bsnz24jx	283	2	example	example	NN
cord-280549-bsnz24jx	283	3	,	,	,
cord-280549-bsnz24jx	283	4	Jiang	Jiang	NNP
cord-280549-bsnz24jx	283	5	et	et	NNP
cord-280549-bsnz24jx	283	6	al	al	NNP
cord-280549-bsnz24jx	283	7	.	.	NNP
cord-280549-bsnz24jx	283	8	have	have	VBP
cord-280549-bsnz24jx	283	9	shown	show	VBN
cord-280549-bsnz24jx	283	10	that	that	DT
cord-280549-bsnz24jx	283	11	expression	expression	NN
cord-280549-bsnz24jx	283	12	of	of	IN
cord-280549-bsnz24jx	283	13	influenza	influenza	NN
cord-280549-bsnz24jx	283	14	A	a	DT
cord-280549-bsnz24jx	283	15	virus	virus	NN
cord-280549-bsnz24jx	283	16	nonstructural	nonstructural	JJ
cord-280549-bsnz24jx	283	17	protein	protein	NN
cord-280549-bsnz24jx	283	18	1	1	CD
cord-280549-bsnz24jx	283	19	(	(	-LRB-
cord-280549-bsnz24jx	283	20	NS1	ns1	NN
cord-280549-bsnz24jx	283	21	)	)	-RRB-
cord-280549-bsnz24jx	283	22	downregulates	downregulate	VBZ
cord-280549-bsnz24jx	283	23	the	the	DT
cord-280549-bsnz24jx	283	24	protein	protein	NN
cord-280549-bsnz24jx	283	25	level	level	NN
cord-280549-bsnz24jx	283	26	and	and	CC
cord-280549-bsnz24jx	283	27	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	283	28	the	the	DT
cord-280549-bsnz24jx	283	29	function	function	NN
cord-280549-bsnz24jx	283	30	of	of	IN
cord-280549-bsnz24jx	283	31	the	the	DT
cord-280549-bsnz24jx	283	32	Ras	Ras	NNP
cord-280549-bsnz24jx	283	33	homolog	homolog	NN
cord-280549-bsnz24jx	283	34	gene	gene	NN
cord-280549-bsnz24jx	283	35	family	family	NN
cord-280549-bsnz24jx	283	36	member	member	NN
cord-280549-bsnz24jx	283	37	A	A	NNP
cord-280549-bsnz24jx	283	38	(	(	-LRB-
cord-280549-bsnz24jx	283	39	RhoA	RhoA	NNP
cord-280549-bsnz24jx	283	40	)	)	-RRB-
cord-280549-bsnz24jx	283	41	,	,	.
cord-280549-bsnz24jx	284	1	a	a	DT
cord-280549-bsnz24jx	284	2	small	small	JJ
cord-280549-bsnz24jx	284	3	GTPase	GTPase	NNP
cord-280549-bsnz24jx	285	1	that	that	IN
cord-280549-bsnz24jx	285	2	,	,	,
cord-280549-bsnz24jx	285	3	besides	besides	IN
cord-280549-bsnz24jx	285	4	its	-PRON-	PRP$
cord-280549-bsnz24jx	285	5	primary	primary	JJ
cord-280549-bsnz24jx	285	6	involvement	involvement	NN
cord-280549-bsnz24jx	285	7	with	with	IN
cord-280549-bsnz24jx	285	8	formation	formation	NN
cord-280549-bsnz24jx	285	9	of	of	IN
cord-280549-bsnz24jx	285	10	actin	actin	JJ
cord-280549-bsnz24jx	285	11	stress	stress	NN
cord-280549-bsnz24jx	285	12	fibers	fiber	NNS
cord-280549-bsnz24jx	285	13	and	and	CC
cord-280549-bsnz24jx	285	14	cytoskeletal	cytoskeletal	JJ
cord-280549-bsnz24jx	285	15	remodeling	remodeling	NN
cord-280549-bsnz24jx	285	16	,	,	,
cord-280549-bsnz24jx	285	17	mediates	mediate	VBZ
cord-280549-bsnz24jx	285	18	cell	cell	NN
cord-280549-bsnz24jx	285	19	cycle	cycle	NN
cord-280549-bsnz24jx	285	20	G1	G1	NNP
cord-280549-bsnz24jx	285	21	/	/	SYM
cord-280549-bsnz24jx	285	22	S	S	NNP
cord-280549-bsnz24jx	285	23	transition	transition	NN
cord-280549-bsnz24jx	286	1	(	(	-LRB-
cord-280549-bsnz24jx	286	2	Jiang	Jiang	NNP
cord-280549-bsnz24jx	286	3	et	et	FW
cord-280549-bsnz24jx	286	4	al	al	NNP
cord-280549-bsnz24jx	286	5	.	.	NNP
cord-280549-bsnz24jx	286	6	,	,	,
cord-280549-bsnz24jx	286	7	2013	2013	CD
cord-280549-bsnz24jx	286	8	)	)	-RRB-
cord-280549-bsnz24jx	286	9	.	.	.
cord-280549-bsnz24jx	287	1	The	the	DT
cord-280549-bsnz24jx	287	2	inhibition	inhibition	NN
cord-280549-bsnz24jx	287	3	of	of	IN
cord-280549-bsnz24jx	287	4	RhoA	RhoA	NNP
cord-280549-bsnz24jx	287	5	activity	activity	NN
cord-280549-bsnz24jx	287	6	by	by	IN
cord-280549-bsnz24jx	287	7	NS1	NS1	NNS
cord-280549-bsnz24jx	287	8	was	be	VBD
cord-280549-bsnz24jx	287	9	reported	report	VBN
cord-280549-bsnz24jx	287	10	to	to	TO
cord-280549-bsnz24jx	287	11	be	be	VB
cord-280549-bsnz24jx	287	12	achieved	achieve	VBN
cord-280549-bsnz24jx	287	13	through	through	IN
cord-280549-bsnz24jx	287	14	physical	physical	JJ
cord-280549-bsnz24jx	287	15	interaction	interaction	NN
cord-280549-bsnz24jx	287	16	between	between	IN
cord-280549-bsnz24jx	287	17	the	the	DT
cord-280549-bsnz24jx	287	18	two	two	CD
cord-280549-bsnz24jx	287	19	proteins	protein	NNS
cord-280549-bsnz24jx	287	20	.	.	.
cord-280549-bsnz24jx	288	1	Wee1	Wee1	NNP
cord-280549-bsnz24jx	288	2	,	,	,
cord-280549-bsnz24jx	288	3	a	a	DT
cord-280549-bsnz24jx	288	4	protein	protein	NN
cord-280549-bsnz24jx	288	5	kinase	kinase	NN
cord-280549-bsnz24jx	288	6	which	which	WDT
cord-280549-bsnz24jx	288	7	inactivates	inactivate	VBZ
cord-280549-bsnz24jx	288	8	CDK1	CDK1	NNP
cord-280549-bsnz24jx	288	9	by	by	IN
cord-280549-bsnz24jx	288	10	phosphorylating	phosphorylate	VBG
cord-280549-bsnz24jx	288	11	the	the	DT
cord-280549-bsnz24jx	288	12	latter	latter	JJ
cord-280549-bsnz24jx	288	13	on	on	IN
cord-280549-bsnz24jx	288	14	Tyr15	Tyr15	NNP
cord-280549-bsnz24jx	288	15	,	,	,
cord-280549-bsnz24jx	288	16	can	can	MD
cord-280549-bsnz24jx	288	17	interact	interact	VB
cord-280549-bsnz24jx	288	18	with	with	IN
cord-280549-bsnz24jx	288	19	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	288	20	viral	viral	JJ
cord-280549-bsnz24jx	288	21	protein	protein	NN
cord-280549-bsnz24jx	288	22	R	r	NN
cord-280549-bsnz24jx	288	23	(	(	-LRB-
cord-280549-bsnz24jx	288	24	Vpr	Vpr	NNP
cord-280549-bsnz24jx	288	25	)	)	-RRB-
cord-280549-bsnz24jx	288	26	in	in	IN
cord-280549-bsnz24jx	288	27	cell	cell	NN
cord-280549-bsnz24jx	288	28	culture	culture	NN
cord-280549-bsnz24jx	288	29	,	,	,
cord-280549-bsnz24jx	288	30	resulting	result	VBG
cord-280549-bsnz24jx	288	31	in	in	IN
cord-280549-bsnz24jx	288	32	enhanced	enhanced	JJ
cord-280549-bsnz24jx	288	33	kinase	kinase	NN
cord-280549-bsnz24jx	288	34	activity	activity	NN
cord-280549-bsnz24jx	288	35	of	of	IN
cord-280549-bsnz24jx	288	36	Wee1	Wee1	NNP
cord-280549-bsnz24jx	288	37	(	(	-LRB-
cord-280549-bsnz24jx	288	38	McGowan	McGowan	NNP
cord-280549-bsnz24jx	288	39	and	and	CC
cord-280549-bsnz24jx	288	40	Russell	Russell	NNP
cord-280549-bsnz24jx	288	41	,	,	,
cord-280549-bsnz24jx	288	42	1993	1993	CD
cord-280549-bsnz24jx	288	43	;	;	:
cord-280549-bsnz24jx	288	44	Kamata	Kamata	NNP
cord-280549-bsnz24jx	288	45	et	et	NNP
cord-280549-bsnz24jx	288	46	al	al	NNP
cord-280549-bsnz24jx	288	47	.	.	NNP
cord-280549-bsnz24jx	288	48	,	,	,
cord-280549-bsnz24jx	288	49	2008	2008	CD
cord-280549-bsnz24jx	288	50	)	)	-RRB-
cord-280549-bsnz24jx	288	51	.	.	.
cord-280549-bsnz24jx	289	1	Although	although	IN
cord-280549-bsnz24jx	289	2	this	this	DT
cord-280549-bsnz24jx	289	3	interaction	interaction	NN
cord-280549-bsnz24jx	289	4	is	be	VBZ
cord-280549-bsnz24jx	289	5	required	require	VBN
cord-280549-bsnz24jx	289	6	,	,	,
cord-280549-bsnz24jx	289	7	it	-PRON-	PRP
cord-280549-bsnz24jx	289	8	is	be	VBZ
cord-280549-bsnz24jx	289	9	not	not	RB
cord-280549-bsnz24jx	289	10	sufficient	sufficient	JJ
cord-280549-bsnz24jx	289	11	for	for	IN
cord-280549-bsnz24jx	289	12	the	the	DT
cord-280549-bsnz24jx	289	13	induction	induction	NN
cord-280549-bsnz24jx	289	14	of	of	IN
cord-280549-bsnz24jx	289	15	cell	cell	NN
cord-280549-bsnz24jx	289	16	cycle	cycle	NN
cord-280549-bsnz24jx	289	17	arrest	arrest	NN
cord-280549-bsnz24jx	289	18	as	as	IN
cord-280549-bsnz24jx	289	19	Vpr	Vpr	NNP
cord-280549-bsnz24jx	289	20	mutants	mutant	NNS
cord-280549-bsnz24jx	289	21	,	,	,
cord-280549-bsnz24jx	289	22	which	which	WDT
cord-280549-bsnz24jx	289	23	are	be	VBP
cord-280549-bsnz24jx	289	24	unable	unable	JJ
cord-280549-bsnz24jx	289	25	to	to	TO
cord-280549-bsnz24jx	289	26	induce	induce	VB
cord-280549-bsnz24jx	289	27	cell	cell	NN
cord-280549-bsnz24jx	289	28	cycle	cycle	NN
cord-280549-bsnz24jx	289	29	arrest	arrest	NN
cord-280549-bsnz24jx	289	30	,	,	,
cord-280549-bsnz24jx	289	31	maintain	maintain	VBP
cord-280549-bsnz24jx	289	32	their	-PRON-	PRP$
cord-280549-bsnz24jx	289	33	binding	binding	NN
cord-280549-bsnz24jx	289	34	and	and	CC
cord-280549-bsnz24jx	289	35	activation	activation	NN
cord-280549-bsnz24jx	289	36	to	to	IN
cord-280549-bsnz24jx	289	37	Wee1	Wee1	NNP
cord-280549-bsnz24jx	289	38	,	,	,
cord-280549-bsnz24jx	289	39	suggesting	suggest	VBG
cord-280549-bsnz24jx	289	40	the	the	DT
cord-280549-bsnz24jx	289	41	existence	existence	NN
cord-280549-bsnz24jx	289	42	of	of	IN
cord-280549-bsnz24jx	289	43	additional	additional	JJ
cord-280549-bsnz24jx	289	44	factors	factor	NNS
cord-280549-bsnz24jx	289	45	in	in	IN
cord-280549-bsnz24jx	289	46	Vpr	Vpr	NNP
cord-280549-bsnz24jx	289	47	-	-	HYPH
cord-280549-bsnz24jx	289	48	mediated	mediate	VBN
cord-280549-bsnz24jx	289	49	activation	activation	NN
cord-280549-bsnz24jx	289	50	of	of	IN
cord-280549-bsnz24jx	289	51	the	the	DT
cord-280549-bsnz24jx	289	52	G2	G2	NNP
cord-280549-bsnz24jx	289	53	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	289	54	(	(	-LRB-
cord-280549-bsnz24jx	289	55	Kamata	Kamata	NNP
cord-280549-bsnz24jx	289	56	et	et	NNP
cord-280549-bsnz24jx	289	57	al	al	NNP
cord-280549-bsnz24jx	289	58	.	.	NNP
cord-280549-bsnz24jx	289	59	,	,	,
cord-280549-bsnz24jx	289	60	2008	2008	CD
cord-280549-bsnz24jx	289	61	)	)	-RRB-
cord-280549-bsnz24jx	289	62	.	.	.
cord-280549-bsnz24jx	290	1	It	-PRON-	PRP
cord-280549-bsnz24jx	290	2	is	be	VBZ
cord-280549-bsnz24jx	290	3	interesting	interesting	JJ
cord-280549-bsnz24jx	290	4	to	to	TO
cord-280549-bsnz24jx	290	5	note	note	VB
cord-280549-bsnz24jx	290	6	that	that	IN
cord-280549-bsnz24jx	290	7	Wee1	Wee1	NNP
cord-280549-bsnz24jx	290	8	blocks	block	VBZ
cord-280549-bsnz24jx	290	9	G2toM	g2tom	NN
cord-280549-bsnz24jx	290	10	transition	transition	NN
cord-280549-bsnz24jx	290	11	by	by	IN
cord-280549-bsnz24jx	290	12	phosphorylating	phosphorylate	VBG
cord-280549-bsnz24jx	290	13	CDK1	CDK1	NNP
cord-280549-bsnz24jx	290	14	,	,	,
cord-280549-bsnz24jx	290	15	whereas	whereas	IN
cord-280549-bsnz24jx	290	16	Cdc25	Cdc25	NNP
cord-280549-bsnz24jx	290	17	triggers	trigger	VBZ
cord-280549-bsnz24jx	290	18	this	this	DT
cord-280549-bsnz24jx	290	19	transition	transition	NN
cord-280549-bsnz24jx	290	20	and	and	CC
cord-280549-bsnz24jx	290	21	entry	entry	NN
cord-280549-bsnz24jx	290	22	into	into	IN
cord-280549-bsnz24jx	290	23	mitosis	mitosis	NN
cord-280549-bsnz24jx	290	24	by	by	IN
cord-280549-bsnz24jx	290	25	dephosphorylating	dephosphorylate	VBG
cord-280549-bsnz24jx	290	26	the	the	DT
cord-280549-bsnz24jx	290	27	same	same	JJ
cord-280549-bsnz24jx	290	28	residues	residue	NNS
cord-280549-bsnz24jx	290	29	on	on	IN
cord-280549-bsnz24jx	290	30	CDK1	CDK1	NNP
cord-280549-bsnz24jx	291	1	(	(	-LRB-
cord-280549-bsnz24jx	291	2	Millar	Millar	NNP
cord-280549-bsnz24jx	291	3	and	and	CC
cord-280549-bsnz24jx	291	4	Russell	Russell	NNP
cord-280549-bsnz24jx	291	5	,	,	,
cord-280549-bsnz24jx	291	6	1992	1992	CD
cord-280549-bsnz24jx	291	7	)	)	-RRB-
cord-280549-bsnz24jx	291	8	.	.	.
cord-280549-bsnz24jx	292	1	In	in	IN
cord-280549-bsnz24jx	292	2	addition	addition	NN
cord-280549-bsnz24jx	292	3	to	to	IN
cord-280549-bsnz24jx	292	4	its	-PRON-	PRP$
cord-280549-bsnz24jx	292	5	binding	binding	NN
cord-280549-bsnz24jx	292	6	with	with	IN
cord-280549-bsnz24jx	292	7	Wee1	Wee1	NNP
cord-280549-bsnz24jx	292	8	,	,	,
cord-280549-bsnz24jx	292	9	Vpr	Vpr	NNP
cord-280549-bsnz24jx	292	10	was	be	VBD
cord-280549-bsnz24jx	292	11	also	also	RB
cord-280549-bsnz24jx	292	12	shown	show	VBN
cord-280549-bsnz24jx	292	13	to	to	TO
cord-280549-bsnz24jx	292	14	associate	associate	VB
cord-280549-bsnz24jx	292	15	with	with	IN
cord-280549-bsnz24jx	292	16	Cdc25C.	Cdc25C.	NNS
cord-280549-bsnz24jx	293	1	This	this	DT
cord-280549-bsnz24jx	293	2	binding	binding	NN
cord-280549-bsnz24jx	293	3	was	be	VBD
cord-280549-bsnz24jx	293	4	mapped	map	VBN
cord-280549-bsnz24jx	293	5	to	to	IN
cord-280549-bsnz24jx	293	6	a	a	DT
cord-280549-bsnz24jx	293	7	site	site	NN
cord-280549-bsnz24jx	293	8	that	that	WDT
cord-280549-bsnz24jx	293	9	lies	lie	VBZ
cord-280549-bsnz24jx	293	10	near	near	RB
cord-280549-bsnz24jx	293	11	but	but	CC
cord-280549-bsnz24jx	293	12	is	be	VBZ
cord-280549-bsnz24jx	293	13	distinct	distinct	JJ
cord-280549-bsnz24jx	293	14	from	from	IN
cord-280549-bsnz24jx	293	15	the	the	DT
cord-280549-bsnz24jx	293	16	catalytic	catalytic	JJ
cord-280549-bsnz24jx	293	17	domain	domain	NN
cord-280549-bsnz24jx	293	18	of	of	IN
cord-280549-bsnz24jx	293	19	Cdc25C	Cdc25C	NNP
cord-280549-bsnz24jx	294	1	(	(	-LRB-
cord-280549-bsnz24jx	294	2	Goh	Goh	NNP
cord-280549-bsnz24jx	294	3	et	et	NNP
cord-280549-bsnz24jx	294	4	al	al	NNP
cord-280549-bsnz24jx	294	5	.	.	NNP
cord-280549-bsnz24jx	294	6	,	,	,
cord-280549-bsnz24jx	294	7	2004	2004	CD
cord-280549-bsnz24jx	294	8	)	)	-RRB-
cord-280549-bsnz24jx	294	9	.	.	.
cord-280549-bsnz24jx	295	1	In	in	IN
cord-280549-bsnz24jx	295	2	accordance	accordance	NN
cord-280549-bsnz24jx	295	3	with	with	IN
cord-280549-bsnz24jx	295	4	its	-PRON-	PRP$
cord-280549-bsnz24jx	295	5	activation	activation	NN
cord-280549-bsnz24jx	295	6	of	of	IN
cord-280549-bsnz24jx	295	7	Wee1	Wee1	NNP
cord-280549-bsnz24jx	295	8	,	,	,
cord-280549-bsnz24jx	295	9	Vpr	Vpr	NNP
cord-280549-bsnz24jx	295	10	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	295	11	the	the	DT
cord-280549-bsnz24jx	295	12	activity	activity	NN
cord-280549-bsnz24jx	295	13	of	of	IN
cord-280549-bsnz24jx	295	14	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	295	15	,	,	,
cord-280549-bsnz24jx	295	16	most	most	RBS
cord-280549-bsnz24jx	295	17	likely	likely	JJ
cord-280549-bsnz24jx	295	18	through	through	IN
cord-280549-bsnz24jx	295	19	its	-PRON-	PRP$
cord-280549-bsnz24jx	295	20	ability	ability	NN
cord-280549-bsnz24jx	295	21	to	to	TO
cord-280549-bsnz24jx	295	22	bind	bind	VB
cord-280549-bsnz24jx	295	23	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	296	1	(	(	-LRB-
cord-280549-bsnz24jx	296	2	Goh	Goh	NNP
cord-280549-bsnz24jx	296	3	et	et	NNP
cord-280549-bsnz24jx	296	4	al	al	NNP
cord-280549-bsnz24jx	296	5	.	.	NNP
cord-280549-bsnz24jx	296	6	,	,	,
cord-280549-bsnz24jx	296	7	2004	2004	CD
cord-280549-bsnz24jx	296	8	)	)	-RRB-
cord-280549-bsnz24jx	296	9	.	.	.
cord-280549-bsnz24jx	297	1	Thus	thus	RB
cord-280549-bsnz24jx	297	2	,	,	,
cord-280549-bsnz24jx	297	3	Vpr	Vpr	NNP
cord-280549-bsnz24jx	297	4	targets	target	VBZ
cord-280549-bsnz24jx	297	5	CDK1	CDK1	NNP
cord-280549-bsnz24jx	297	6	to	to	TO
cord-280549-bsnz24jx	297	7	mediate	mediate	VB
cord-280549-bsnz24jx	297	8	G2	G2	NNP
cord-280549-bsnz24jx	297	9	/	/	SYM
cord-280549-bsnz24jx	297	10	M	M	NNP
cord-280549-bsnz24jx	297	11	arrest	arrest	NN
cord-280549-bsnz24jx	297	12	acting	act	VBG
cord-280549-bsnz24jx	297	13	on	on	IN
cord-280549-bsnz24jx	297	14	both	both	DT
cord-280549-bsnz24jx	297	15	Wee1	Wee1	NNP
cord-280549-bsnz24jx	297	16	and	and	CC
cord-280549-bsnz24jx	297	17	Cdc25C.	Cdc25C.	NNS
cord-280549-bsnz24jx	298	1	Furthermore	furthermore	RB
cord-280549-bsnz24jx	298	2	,	,	,
cord-280549-bsnz24jx	298	3	several	several	JJ
cord-280549-bsnz24jx	298	4	groups	group	NNS
cord-280549-bsnz24jx	298	5	recently	recently	RB
cord-280549-bsnz24jx	298	6	demonstrated	demonstrate	VBD
cord-280549-bsnz24jx	298	7	a	a	DT
cord-280549-bsnz24jx	298	8	direct	direct	JJ
cord-280549-bsnz24jx	298	9	interaction	interaction	NN
cord-280549-bsnz24jx	298	10	of	of	IN
cord-280549-bsnz24jx	298	11	Vpr	Vpr	NNP
cord-280549-bsnz24jx	298	12	withSLX4	withslx4	NN
cord-280549-bsnz24jx	298	13	,	,	,
cord-280549-bsnz24jx	298	14	a	a	DT
cord-280549-bsnz24jx	298	15	scaffold	scaffold	NN
cord-280549-bsnz24jx	298	16	for	for	IN
cord-280549-bsnz24jx	298	17	the	the	DT
cord-280549-bsnz24jx	298	18	formation	formation	NN
cord-280549-bsnz24jx	298	19	of	of	IN
cord-280549-bsnz24jx	298	20	a	a	DT
cord-280549-bsnz24jx	298	21	heterodimeric	heterodimeric	JJ
cord-280549-bsnz24jx	298	22	structure	structure	NN
cord-280549-bsnz24jx	298	23	-	-	HYPH
cord-280549-bsnz24jx	298	24	specific	specific	JJ
cord-280549-bsnz24jx	298	25	endonuclease	endonuclease	NN
cord-280549-bsnz24jx	298	26	consisted	consist	VBN
cord-280549-bsnz24jx	298	27	of	of	IN
cord-280549-bsnz24jx	298	28	MUS81	MUS81	NNP
cord-280549-bsnz24jx	298	29	and	and	CC
cord-280549-bsnz24jx	298	30	EME1	EME1	NNP
cord-280549-bsnz24jx	299	1	(	(	-LRB-
cord-280549-bsnz24jx	299	2	Fekairi	Fekairi	NNP
cord-280549-bsnz24jx	299	3	et	et	NNP
cord-280549-bsnz24jx	299	4	al	al	NNP
cord-280549-bsnz24jx	299	5	.	.	NNP
cord-280549-bsnz24jx	299	6	,	,	,
cord-280549-bsnz24jx	299	7	2009	2009	CD
cord-280549-bsnz24jx	299	8	;	;	:
cord-280549-bsnz24jx	299	9	Muñoz	Muñoz	NNP
cord-280549-bsnz24jx	299	10	et	et	NNP
cord-280549-bsnz24jx	299	11	al	al	NNP
cord-280549-bsnz24jx	299	12	.	.	.
cord-280549-bsnz24jx	300	1	,	,	,
cord-280549-bsnz24jx	300	2	2009	2009	CD
cord-280549-bsnz24jx	300	3	;	;	:
cord-280549-bsnz24jx	300	4	Svendsen	Svendsen	NNP
cord-280549-bsnz24jx	300	5	et	et	NNP
cord-280549-bsnz24jx	300	6	al	al	NNP
cord-280549-bsnz24jx	300	7	.	.	NNP
cord-280549-bsnz24jx	300	8	,	,	,
cord-280549-bsnz24jx	300	9	2009	2009	CD
cord-280549-bsnz24jx	300	10	;	;	.
cord-280549-bsnz24jx	301	1	Kim	Kim	NNP
cord-280549-bsnz24jx	301	2	et	et	NNP
cord-280549-bsnz24jx	301	3	al	al	NNP
cord-280549-bsnz24jx	301	4	.	.	.
cord-280549-bsnz24jx	302	1	,	,	,
cord-280549-bsnz24jx	302	2	2013	2013	CD
cord-280549-bsnz24jx	302	3	;	;	:
cord-280549-bsnz24jx	302	4	Laguette	Laguette	NNP
cord-280549-bsnz24jx	302	5	et	et	FW
cord-280549-bsnz24jx	302	6	al	al	NNP
cord-280549-bsnz24jx	302	7	.	.	.
cord-280549-bsnz24jx	303	1	,	,	,
cord-280549-bsnz24jx	303	2	2014	2014	CD
cord-280549-bsnz24jx	303	3	)	)	-RRB-
cord-280549-bsnz24jx	303	4	.	.	.
cord-280549-bsnz24jx	304	1	Thus	thus	RB
cord-280549-bsnz24jx	304	2	,	,	,
cord-280549-bsnz24jx	304	3	binding	bind	VBG
cord-280549-bsnz24jx	304	4	of	of	IN
cord-280549-bsnz24jx	304	5	Vpr	Vpr	NNP
cord-280549-bsnz24jx	304	6	to	to	IN
cord-280549-bsnz24jx	304	7	SLX4	SLX4	NNP
cord-280549-bsnz24jx	304	8	activates	activate	VBZ
cord-280549-bsnz24jx	304	9	the	the	DT
cord-280549-bsnz24jx	304	10	MUS81-EME1	mus81-eme1	CD
cord-280549-bsnz24jx	304	11	endonuclease	endonuclease	NN
cord-280549-bsnz24jx	304	12	,	,	,
cord-280549-bsnz24jx	304	13	leading	lead	VBG
cord-280549-bsnz24jx	304	14	to	to	IN
cord-280549-bsnz24jx	304	15	replication	replication	NN
cord-280549-bsnz24jx	304	16	stress	stress	NN
cord-280549-bsnz24jx	304	17	.	.	.
cord-280549-bsnz24jx	305	1	The	the	DT
cord-280549-bsnz24jx	305	2	observation	observation	NN
cord-280549-bsnz24jx	305	3	that	that	IN
cord-280549-bsnz24jx	305	4	G2	G2	NNP
cord-280549-bsnz24jx	305	5	/	/	SYM
cord-280549-bsnz24jx	305	6	M	M	NNP
cord-280549-bsnz24jx	305	7	arrest	arrest	NN
cord-280549-bsnz24jx	305	8	-	-	HYPH
cord-280549-bsnz24jx	305	9	deficient	deficient	JJ
cord-280549-bsnz24jx	305	10	Vpr	Vpr	NNP
cord-280549-bsnz24jx	305	11	mutants	mutant	NNS
cord-280549-bsnz24jx	305	12	fail	fail	VBP
cord-280549-bsnz24jx	305	13	to	to	TO
cord-280549-bsnz24jx	305	14	interact	interact	VB
cord-280549-bsnz24jx	305	15	with	with	IN
cord-280549-bsnz24jx	305	16	SLX4	SLX4	NNP
cord-280549-bsnz24jx	305	17	,	,	,
cord-280549-bsnz24jx	305	18	and	and	CC
cord-280549-bsnz24jx	305	19	that	that	IN
cord-280549-bsnz24jx	305	20	silencing	silencing	NN
cord-280549-bsnz24jx	305	21	of	of	IN
cord-280549-bsnz24jx	305	22	SLX4	SLX4	NNP
cord-280549-bsnz24jx	305	23	reduces	reduce	VBZ
cord-280549-bsnz24jx	305	24	Vpr	Vpr	NNP
cord-280549-bsnz24jx	305	25	-	-	HYPH
cord-280549-bsnz24jx	305	26	dependent	dependent	JJ
cord-280549-bsnz24jx	305	27	cell	cell	NN
cord-280549-bsnz24jx	305	28	cycle	cycle	NN
cord-280549-bsnz24jx	305	29	perturbation	perturbation	NN
cord-280549-bsnz24jx	305	30	highlight	highlight	VBP
cord-280549-bsnz24jx	305	31	the	the	DT
cord-280549-bsnz24jx	305	32	significance	significance	NN
cord-280549-bsnz24jx	305	33	of	of	IN
cord-280549-bsnz24jx	305	34	Vpr	Vpr	NNP
cord-280549-bsnz24jx	305	35	-	-	HYPH
cord-280549-bsnz24jx	305	36	SLX4	SLX4	NNP
cord-280549-bsnz24jx	305	37	association	association	NN
cord-280549-bsnz24jx	305	38	in	in	IN
cord-280549-bsnz24jx	305	39	Vpr	Vpr	NNP
cord-280549-bsnz24jx	305	40	-	-	HYPH
cord-280549-bsnz24jx	305	41	induced	induce	VBN
cord-280549-bsnz24jx	305	42	G2	G2	NNP
cord-280549-bsnz24jx	305	43	/	/	SYM
cord-280549-bsnz24jx	305	44	M	M	NNP
cord-280549-bsnz24jx	305	45	arrest	arrest	NN
cord-280549-bsnz24jx	305	46	(	(	-LRB-
cord-280549-bsnz24jx	305	47	Laguette	Laguette	NNP
cord-280549-bsnz24jx	305	48	et	et	FW
cord-280549-bsnz24jx	305	49	al	al	NNP
cord-280549-bsnz24jx	305	50	.	.	NNP
cord-280549-bsnz24jx	305	51	,	,	,
cord-280549-bsnz24jx	305	52	2014	2014	CD
cord-280549-bsnz24jx	305	53	)	)	-RRB-
cord-280549-bsnz24jx	305	54	.	.	.
cord-280549-bsnz24jx	306	1	In	in	IN
cord-280549-bsnz24jx	306	2	accordance	accordance	NN
cord-280549-bsnz24jx	306	3	,	,	,
cord-280549-bsnz24jx	306	4	the	the	DT
cord-280549-bsnz24jx	306	5	use	use	NN
cord-280549-bsnz24jx	306	6	of	of	IN
cord-280549-bsnz24jx	306	7	a	a	DT
cord-280549-bsnz24jx	306	8	panel	panel	NN
cord-280549-bsnz24jx	306	9	of	of	IN
cord-280549-bsnz24jx	306	10	simian	simian	JJ
cord-280549-bsnz24jx	306	11	immunodeficiency	immunodeficiency	NN
cord-280549-bsnz24jx	306	12	virus	virus	NN
cord-280549-bsnz24jx	306	13	(	(	-LRB-
cord-280549-bsnz24jx	306	14	SIV	SIV	NNP
cord-280549-bsnz24jx	306	15	)	)	-RRB-
cord-280549-bsnz24jx	306	16	Vprs	Vprs	NNP
cord-280549-bsnz24jx	306	17	that	that	WDT
cord-280549-bsnz24jx	306	18	differ	differ	VBP
cord-280549-bsnz24jx	306	19	in	in	IN
cord-280549-bsnz24jx	306	20	their	-PRON-	PRP$
cord-280549-bsnz24jx	306	21	ability	ability	NN
cord-280549-bsnz24jx	306	22	to	to	TO
cord-280549-bsnz24jx	306	23	promote	promote	VB
cord-280549-bsnz24jx	306	24	cell	cell	NN
cord-280549-bsnz24jx	306	25	cycle	cycle	NN
cord-280549-bsnz24jx	306	26	arrest	arrest	NN
cord-280549-bsnz24jx	306	27	demonstrated	demonstrate	VBD
cord-280549-bsnz24jx	306	28	the	the	DT
cord-280549-bsnz24jx	306	29	correlation	correlation	NN
cord-280549-bsnz24jx	306	30	between	between	IN
cord-280549-bsnz24jx	306	31	Vpr	Vpr	NNP
cord-280549-bsnz24jx	306	32	-	-	HYPH
cord-280549-bsnz24jx	306	33	SLX4binding	slx4binding	NN
cord-280549-bsnz24jx	306	34	and	and	CC
cord-280549-bsnz24jx	306	35	the	the	DT
cord-280549-bsnz24jx	306	36	G2	G2	NNP
cord-280549-bsnz24jx	306	37	/	/	SYM
cord-280549-bsnz24jx	306	38	M	M	NNP
cord-280549-bsnz24jx	306	39	arrest	arrest	NN
cord-280549-bsnz24jx	306	40	effect	effect	NN
cord-280549-bsnz24jx	306	41	of	of	IN
cord-280549-bsnz24jx	306	42	Vpr	Vpr	NNP
cord-280549-bsnz24jx	306	43	(	(	-LRB-
cord-280549-bsnz24jx	306	44	Berger	Berger	NNP
cord-280549-bsnz24jx	306	45	et	et	NNP
cord-280549-bsnz24jx	306	46	al	al	NNP
cord-280549-bsnz24jx	306	47	.	.	NNP
cord-280549-bsnz24jx	306	48	,	,	,
cord-280549-bsnz24jx	306	49	2015	2015	CD
cord-280549-bsnz24jx	306	50	)	)	-RRB-
cord-280549-bsnz24jx	306	51	.	.	.
cord-280549-bsnz24jx	307	1	DNA	dna	NN
cord-280549-bsnz24jx	307	2	damage	damage	NN
cord-280549-bsnz24jx	307	3	-	-	HYPH
cord-280549-bsnz24jx	307	4	binding	bind	VBG
cord-280549-bsnz24jx	307	5	(	(	-LRB-
cord-280549-bsnz24jx	307	6	DDB	DDB	NNP
cord-280549-bsnz24jx	307	7	)	)	-RRB-
cord-280549-bsnz24jx	307	8	protein	protein	NN
cord-280549-bsnz24jx	307	9	,	,	,
cord-280549-bsnz24jx	307	10	which	which	WDT
cord-280549-bsnz24jx	307	11	constitutesDDB1	constitutesddb1	NN
cord-280549-bsnz24jx	307	12	and	and	CC
cord-280549-bsnz24jx	307	13	DDB2	DDB2	NNP
cord-280549-bsnz24jx	307	14	subunits	subunit	NNS
cord-280549-bsnz24jx	307	15	,	,	,
cord-280549-bsnz24jx	307	16	translocates	translocate	NNS
cord-280549-bsnz24jx	307	17	to	to	IN
cord-280549-bsnz24jx	307	18	the	the	DT
cord-280549-bsnz24jx	307	19	nucleus	nucleus	NN
cord-280549-bsnz24jx	307	20	to	to	TO
cord-280549-bsnz24jx	307	21	mediate	mediate	VB
cord-280549-bsnz24jx	307	22	DNA	dna	NN
cord-280549-bsnz24jx	307	23	repair	repair	NN
cord-280549-bsnz24jx	307	24	in	in	IN
cord-280549-bsnz24jx	307	25	response	response	NN
cord-280549-bsnz24jx	307	26	to	to	IN
cord-280549-bsnz24jx	307	27	DNA	dna	NN
cord-280549-bsnz24jx	307	28	damage	damage	NN
cord-280549-bsnz24jx	307	29	signal	signal	NN
cord-280549-bsnz24jx	307	30	(	(	-LRB-
cord-280549-bsnz24jx	307	31	Wittschieben	Wittschieben	NNP
cord-280549-bsnz24jx	307	32	and	and	CC
cord-280549-bsnz24jx	307	33	Wood	Wood	NNP
cord-280549-bsnz24jx	307	34	,	,	,
cord-280549-bsnz24jx	307	35	2003	2003	CD
cord-280549-bsnz24jx	307	36	;	;	:
cord-280549-bsnz24jx	307	37	Iovine	Iovine	NNP
cord-280549-bsnz24jx	307	38	et	et	NNP
cord-280549-bsnz24jx	307	39	al	al	NNP
cord-280549-bsnz24jx	307	40	.	.	NNP
cord-280549-bsnz24jx	307	41	,	,	,
cord-280549-bsnz24jx	307	42	2011	2011	CD
cord-280549-bsnz24jx	307	43	)	)	-RRB-
cord-280549-bsnz24jx	307	44	.	.	.
cord-280549-bsnz24jx	308	1	The	the	DT
cord-280549-bsnz24jx	308	2	formation	formation	NN
cord-280549-bsnz24jx	308	3	of	of	IN
cord-280549-bsnz24jx	308	4	a	a	DT
cord-280549-bsnz24jx	308	5	complex	complex	JJ
cord-280549-bsnz24jx	308	6	comprising	comprise	VBG
cord-280549-bsnz24jx	308	7	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	308	8	Vpr	Vpr	NNP
cord-280549-bsnz24jx	308	9	,	,	,
cord-280549-bsnz24jx	308	10	DDB1-Cullin	DDB1-Cullin	NNP
cord-280549-bsnz24jx	308	11	4A	4a	NN
cord-280549-bsnz24jx	308	12	-	-	HYPH
cord-280549-bsnz24jx	308	13	associated	associate	VBN
cord-280549-bsnz24jx	308	14	factor	factor	NN
cord-280549-bsnz24jx	308	15	1	1	CD
cord-280549-bsnz24jx	308	16	(	(	-LRB-
cord-280549-bsnz24jx	308	17	DCAF1	DCAF1	NNP
cord-280549-bsnz24jx	308	18	)	)	-RRB-
cord-280549-bsnz24jx	308	19	,	,	,
cord-280549-bsnz24jx	308	20	and	and	CC
cord-280549-bsnz24jx	308	21	DDB1	DDB1	NNP
cord-280549-bsnz24jx	308	22	has	have	VBZ
cord-280549-bsnz24jx	308	23	been	be	VBN
cord-280549-bsnz24jx	308	24	implicated	implicate	VBN
cord-280549-bsnz24jx	308	25	as	as	IN
cord-280549-bsnz24jx	308	26	the	the	DT
cord-280549-bsnz24jx	308	27	upstream	upstream	JJ
cord-280549-bsnz24jx	308	28	event	event	NN
cord-280549-bsnz24jx	308	29	in	in	IN
cord-280549-bsnz24jx	308	30	Vpr	Vpr	NNP
cord-280549-bsnz24jx	308	31	-	-	HYPH
cord-280549-bsnz24jx	308	32	triggered	trigger	VBN
cord-280549-bsnz24jx	308	33	G2	G2	NNP
cord-280549-bsnz24jx	308	34	/	/	SYM
cord-280549-bsnz24jx	308	35	M	M	NNP
cord-280549-bsnz24jx	308	36	arrest	arrest	NN
cord-280549-bsnz24jx	308	37	(	(	-LRB-
cord-280549-bsnz24jx	308	38	Le	Le	NNP
cord-280549-bsnz24jx	308	39	Rouzic	Rouzic	NNP
cord-280549-bsnz24jx	308	40	et	et	NNP
cord-280549-bsnz24jx	308	41	al	al	NNP
cord-280549-bsnz24jx	308	42	.	.	NNP
cord-280549-bsnz24jx	308	43	,	,	,
cord-280549-bsnz24jx	308	44	2007	2007	CD
cord-280549-bsnz24jx	308	45	;	;	:
cord-280549-bsnz24jx	308	46	Schröfelbauer	Schröfelbauer	NNP
cord-280549-bsnz24jx	308	47	et	et	NNP
cord-280549-bsnz24jx	308	48	al	al	NNP
cord-280549-bsnz24jx	308	49	.	.	NNP
cord-280549-bsnz24jx	308	50	,	,	,
cord-280549-bsnz24jx	308	51	2007	2007	CD
cord-280549-bsnz24jx	308	52	)	)	-RRB-
cord-280549-bsnz24jx	308	53	.	.	.
cord-280549-bsnz24jx	309	1	It	-PRON-	PRP
cord-280549-bsnz24jx	309	2	is	be	VBZ
cord-280549-bsnz24jx	309	3	known	know	VBN
cord-280549-bsnz24jx	309	4	that	that	IN
cord-280549-bsnz24jx	309	5	Vpr	Vpr	NNP
cord-280549-bsnz24jx	309	6	hampers	hamper	VBZ
cord-280549-bsnz24jx	309	7	the	the	DT
cord-280549-bsnz24jx	309	8	nuclear	nuclear	JJ
cord-280549-bsnz24jx	309	9	localization	localization	NN
cord-280549-bsnz24jx	309	10	of	of	IN
cord-280549-bsnz24jx	309	11	DDB1	DDB1	NNP
cord-280549-bsnz24jx	309	12	,	,	,
cord-280549-bsnz24jx	309	13	and	and	CC
cord-280549-bsnz24jx	309	14	interferes	interfere	VBZ
cord-280549-bsnz24jx	309	15	with	with	IN
cord-280549-bsnz24jx	309	16	the	the	DT
cord-280549-bsnz24jx	309	17	binding	binding	NN
cord-280549-bsnz24jx	309	18	of	of	IN
cord-280549-bsnz24jx	309	19	DDB1	DDB1	NNPS
cord-280549-bsnz24jx	309	20	to	to	IN
cord-280549-bsnz24jx	309	21	damaged	damage	VBN
cord-280549-bsnz24jx	309	22	DNA	dna	NN
cord-280549-bsnz24jx	309	23	as	as	IN
cord-280549-bsnz24jx	309	24	detected	detect	VBN
cord-280549-bsnz24jx	309	25	by	by	IN
cord-280549-bsnz24jx	309	26	an	an	DT
cord-280549-bsnz24jx	309	27	electrophoretic	electrophoretic	JJ
cord-280549-bsnz24jx	309	28	mobility	mobility	NN
cord-280549-bsnz24jx	309	29	shift	shift	NN
cord-280549-bsnz24jx	309	30	assay	assay	NN
cord-280549-bsnz24jx	309	31	(	(	-LRB-
cord-280549-bsnz24jx	309	32	EMSA	EMSA	NNP
cord-280549-bsnz24jx	309	33	)	)	-RRB-
cord-280549-bsnz24jx	310	1	(	(	-LRB-
cord-280549-bsnz24jx	310	2	Schröfelbauer	Schröfelbauer	NNP
cord-280549-bsnz24jx	310	3	et	et	NNP
cord-280549-bsnz24jx	310	4	al	al	NNP
cord-280549-bsnz24jx	310	5	.	.	NNP
cord-280549-bsnz24jx	310	6	,	,	,
cord-280549-bsnz24jx	310	7	2007	2007	CD
cord-280549-bsnz24jx	310	8	)	)	-RRB-
cord-280549-bsnz24jx	310	9	.	.	.
cord-280549-bsnz24jx	311	1	Moreover	moreover	RB
cord-280549-bsnz24jx	311	2	,	,	,
cord-280549-bsnz24jx	311	3	the	the	DT
cord-280549-bsnz24jx	311	4	association	association	NN
cord-280549-bsnz24jx	311	5	of	of	IN
cord-280549-bsnz24jx	311	6	Vpr	Vpr	NNP
cord-280549-bsnz24jx	311	7	with	with	IN
cord-280549-bsnz24jx	311	8	DDB1	DDB1	NNP
cord-280549-bsnz24jx	311	9	disrupts	disrupt	VBZ
cord-280549-bsnz24jx	311	10	complex	complex	JJ
cord-280549-bsnz24jx	311	11	formation	formation	NN
cord-280549-bsnz24jx	311	12	between	between	IN
cord-280549-bsnz24jx	311	13	DDB1	DDB1	NNP
cord-280549-bsnz24jx	311	14	and	and	CC
cord-280549-bsnz24jx	311	15	DDB2	DDB2	NNP
cord-280549-bsnz24jx	311	16	,	,	,
cord-280549-bsnz24jx	311	17	which	which	WDT
cord-280549-bsnz24jx	311	18	is	be	VBZ
cord-280549-bsnz24jx	311	19	a	a	DT
cord-280549-bsnz24jx	311	20	prerequisite	prerequisite	NN
cord-280549-bsnz24jx	311	21	for	for	IN
cord-280549-bsnz24jx	311	22	DNA	dna	NN
cord-280549-bsnz24jx	311	23	repair	repair	NN
cord-280549-bsnz24jx	311	24	(	(	-LRB-
cord-280549-bsnz24jx	311	25	Schröfelbauer	Schröfelbauer	NNP
cord-280549-bsnz24jx	311	26	et	et	FW
cord-280549-bsnz24jx	311	27	al	al	NNP
cord-280549-bsnz24jx	311	28	.	.	NNP
cord-280549-bsnz24jx	311	29	,	,	,
cord-280549-bsnz24jx	311	30	2007	2007	CD
cord-280549-bsnz24jx	311	31	)	)	-RRB-
cord-280549-bsnz24jx	311	32	.	.	.
cord-280549-bsnz24jx	312	1	The	the	DT
cord-280549-bsnz24jx	312	2	significance	significance	NN
cord-280549-bsnz24jx	312	3	of	of	IN
cord-280549-bsnz24jx	312	4	Vpr	Vpr	NNP
cord-280549-bsnz24jx	312	5	-	-	HYPH
cord-280549-bsnz24jx	312	6	DDB1	DDB1	NNP
cord-280549-bsnz24jx	312	7	interaction	interaction	NN
cord-280549-bsnz24jx	312	8	in	in	IN
cord-280549-bsnz24jx	312	9	Vpr	Vpr	NNP
cord-280549-bsnz24jx	312	10	-	-	HYPH
cord-280549-bsnz24jx	312	11	mediated	mediate	VBN
cord-280549-bsnz24jx	312	12	cytostatic	cytostatic	JJ
cord-280549-bsnz24jx	312	13	effect	effect	NN
cord-280549-bsnz24jx	312	14	was	be	VBD
cord-280549-bsnz24jx	312	15	revealed	reveal	VBN
cord-280549-bsnz24jx	312	16	through	through	IN
cord-280549-bsnz24jx	312	17	the	the	DT
cord-280549-bsnz24jx	312	18	use	use	NN
cord-280549-bsnz24jx	312	19	of	of	IN
cord-280549-bsnz24jx	312	20	DDB1	DDB1	NNP
cord-280549-bsnz24jx	312	21	bindingdeficient	bindingdeficient	NN
cord-280549-bsnz24jx	312	22	Vpr	Vpr	NNP
cord-280549-bsnz24jx	312	23	mutant	mutant	JJ
cord-280549-bsnz24jx	312	24	(	(	-LRB-
cord-280549-bsnz24jx	312	25	Schröfelbauer	Schröfelbauer	NNP
cord-280549-bsnz24jx	312	26	et	et	NNP
cord-280549-bsnz24jx	312	27	al	al	NNP
cord-280549-bsnz24jx	312	28	.	.	NNP
cord-280549-bsnz24jx	312	29	,	,	,
cord-280549-bsnz24jx	312	30	2007	2007	CD
cord-280549-bsnz24jx	312	31	)	)	-RRB-
cord-280549-bsnz24jx	312	32	.	.	.
cord-280549-bsnz24jx	313	1	It	-PRON-	PRP
cord-280549-bsnz24jx	313	2	is	be	VBZ
cord-280549-bsnz24jx	313	3	worth	worth	JJ
cord-280549-bsnz24jx	313	4	mentioning	mention	VBG
cord-280549-bsnz24jx	313	5	that	that	IN
cord-280549-bsnz24jx	313	6	one	one	CD
cord-280549-bsnz24jx	313	7	of	of	IN
cord-280549-bsnz24jx	313	8	the	the	DT
cord-280549-bsnz24jx	313	9	multiple	multiple	JJ
cord-280549-bsnz24jx	313	10	functions	function	NNS
cord-280549-bsnz24jx	313	11	of	of	IN
cord-280549-bsnz24jx	313	12	DDB1	DDB1	NNP
cord-280549-bsnz24jx	313	13	is	be	VBZ
cord-280549-bsnz24jx	313	14	to	to	TO
cord-280549-bsnz24jx	313	15	act	act	VB
cord-280549-bsnz24jx	313	16	as	as	IN
cord-280549-bsnz24jx	313	17	a	a	DT
cord-280549-bsnz24jx	313	18	component	component	NN
cord-280549-bsnz24jx	313	19	of	of	IN
cord-280549-bsnz24jx	313	20	an	an	DT
cord-280549-bsnz24jx	313	21	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	313	22	-	-	HYPH
cord-280549-bsnz24jx	313	23	E3	e3	NN
cord-280549-bsnz24jx	313	24	ligase	ligase	NN
cord-280549-bsnz24jx	313	25	complex	complex	NN
cord-280549-bsnz24jx	313	26	that	that	WDT
cord-280549-bsnz24jx	313	27	targets	target	VBZ
cord-280549-bsnz24jx	313	28	cell	cell	NN
cord-280549-bsnz24jx	313	29	cycle	cycle	NN
cord-280549-bsnz24jx	313	30	regulatory	regulatory	JJ
cord-280549-bsnz24jx	313	31	proteins	protein	NNS
cord-280549-bsnz24jx	313	32	such	such	JJ
cord-280549-bsnz24jx	313	33	as	as	IN
cord-280549-bsnz24jx	313	34	p27	p27	NN
cord-280549-bsnz24jx	313	35	KIP1	KIP1	NNP
cord-280549-bsnz24jx	313	36	for	for	IN
cord-280549-bsnz24jx	313	37	proteasomal	proteasomal	JJ
cord-280549-bsnz24jx	313	38	degradation	degradation	NN
cord-280549-bsnz24jx	313	39	(	(	-LRB-
cord-280549-bsnz24jx	313	40	Bondar	Bondar	NNP
cord-280549-bsnz24jx	313	41	et	et	NNP
cord-280549-bsnz24jx	313	42	al	al	NNP
cord-280549-bsnz24jx	313	43	.	.	NNP
cord-280549-bsnz24jx	313	44	,	,	,
cord-280549-bsnz24jx	313	45	2006	2006	CD
cord-280549-bsnz24jx	313	46	)	)	-RRB-
cord-280549-bsnz24jx	313	47	.	.	.
cord-280549-bsnz24jx	314	1	It	-PRON-	PRP
cord-280549-bsnz24jx	314	2	will	will	MD
cord-280549-bsnz24jx	314	3	be	be	VB
cord-280549-bsnz24jx	314	4	of	of	IN
cord-280549-bsnz24jx	314	5	interests	interest	NNS
cord-280549-bsnz24jx	314	6	to	to	TO
cord-280549-bsnz24jx	314	7	investigate	investigate	VB
cord-280549-bsnz24jx	314	8	whether	whether	IN
cord-280549-bsnz24jx	314	9	the	the	DT
cord-280549-bsnz24jx	314	10	association	association	NN
cord-280549-bsnz24jx	314	11	of	of	IN
cord-280549-bsnz24jx	314	12	Vpr	Vpr	NNP
cord-280549-bsnz24jx	314	13	with	with	IN
cord-280549-bsnz24jx	314	14	DDB1	DDB1	NNP
cord-280549-bsnz24jx	314	15	could	could	MD
cord-280549-bsnz24jx	314	16	antagonize	antagonize	VB
cord-280549-bsnz24jx	314	17	its	-PRON-	PRP$
cord-280549-bsnz24jx	314	18	role	role	NN
cord-280549-bsnz24jx	314	19	in	in	IN
cord-280549-bsnz24jx	314	20	the	the	DT
cord-280549-bsnz24jx	314	21	hydrolysis	hydrolysis	NN
cord-280549-bsnz24jx	314	22	of	of	IN
cord-280549-bsnz24jx	314	23	p27	p27	NN
cord-280549-bsnz24jx	314	24	KIP1	KIP1	NNP
cord-280549-bsnz24jx	314	25	and	and	CC
cord-280549-bsnz24jx	314	26	other	other	JJ
cord-280549-bsnz24jx	314	27	cell	cell	NN
cord-280549-bsnz24jx	314	28	cycle	cycle	NN
cord-280549-bsnz24jx	314	29	effectors	effector	NNS
cord-280549-bsnz24jx	314	30	,	,	,
cord-280549-bsnz24jx	314	31	thus	thus	RB
cord-280549-bsnz24jx	314	32	contributing	contribute	VBG
cord-280549-bsnz24jx	314	33	to	to	IN
cord-280549-bsnz24jx	314	34	cell	cell	NN
cord-280549-bsnz24jx	314	35	cycle	cycle	NN
cord-280549-bsnz24jx	314	36	arrest	arrest	NN
cord-280549-bsnz24jx	314	37	.	.	.
cord-280549-bsnz24jx	315	1	Indirect	indirect	JJ
cord-280549-bsnz24jx	315	2	support	support	NN
cord-280549-bsnz24jx	315	3	for	for	IN
cord-280549-bsnz24jx	315	4	this	this	DT
cord-280549-bsnz24jx	315	5	hypothesis	hypothesis	NN
cord-280549-bsnz24jx	315	6	stems	stem	VBZ
cord-280549-bsnz24jx	315	7	from	from	IN
cord-280549-bsnz24jx	315	8	experiments	experiment	NNS
cord-280549-bsnz24jx	315	9	with	with	IN
cord-280549-bsnz24jx	315	10	transient	transient	JJ
cord-280549-bsnz24jx	315	11	expression	expression	NN
cord-280549-bsnz24jx	315	12	of	of	IN
cord-280549-bsnz24jx	315	13	HBV	HBV	NNP
cord-280549-bsnz24jx	315	14	HBx	HBx	NNP
cord-280549-bsnz24jx	315	15	,	,	,
cord-280549-bsnz24jx	315	16	which	which	WDT
cord-280549-bsnz24jx	315	17	induces	induce	VBZ
cord-280549-bsnz24jx	315	18	accumulation	accumulation	NN
cord-280549-bsnz24jx	315	19	of	of	IN
cord-280549-bsnz24jx	315	20	lagging	lagging	JJ
cord-280549-bsnz24jx	315	21	chromosomes	chromosome	NNS
cord-280549-bsnz24jx	315	22	and	and	CC
cord-280549-bsnz24jx	315	23	other	other	JJ
cord-280549-bsnz24jx	315	24	mitotic	mitotic	JJ
cord-280549-bsnz24jx	315	25	aberrations	aberration	NNS
cord-280549-bsnz24jx	315	26	,	,	,
cord-280549-bsnz24jx	315	27	leading	lead	VBG
cord-280549-bsnz24jx	315	28	to	to	IN
cord-280549-bsnz24jx	315	29	the	the	DT
cord-280549-bsnz24jx	315	30	activation	activation	NN
cord-280549-bsnz24jx	315	31	of	of	IN
cord-280549-bsnz24jx	315	32	DNA	dna	NN
cord-280549-bsnz24jx	315	33	replication	replication	NN
cord-280549-bsnz24jx	315	34	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	315	35	with	with	IN
cord-280549-bsnz24jx	315	36	a	a	DT
cord-280549-bsnz24jx	315	37	delayed	delay	VBN
cord-280549-bsnz24jx	315	38	S	s	NN
cord-280549-bsnz24jx	315	39	phase	phase	NN
cord-280549-bsnz24jx	315	40	progression	progression	NN
cord-280549-bsnz24jx	315	41	(	(	-LRB-
cord-280549-bsnz24jx	315	42	Martin	Martin	NNP
cord-280549-bsnz24jx	315	43	-	-	HYPH
cord-280549-bsnz24jx	315	44	Lluesma	Lluesma	NNP
cord-280549-bsnz24jx	315	45	et	et	FW
cord-280549-bsnz24jx	315	46	al	al	NNP
cord-280549-bsnz24jx	315	47	.	.	NNP
cord-280549-bsnz24jx	315	48	,	,	,
cord-280549-bsnz24jx	315	49	2008	2008	CD
cord-280549-bsnz24jx	315	50	)	)	-RRB-
cord-280549-bsnz24jx	315	51	.	.	.
cord-280549-bsnz24jx	316	1	The	the	DT
cord-280549-bsnz24jx	316	2	use	use	NN
cord-280549-bsnz24jx	316	3	of	of	IN
cord-280549-bsnz24jx	316	4	an	an	DT
cord-280549-bsnz24jx	316	5	HBx	hbx	NN
cord-280549-bsnz24jx	316	6	mutant	mutant	NN
cord-280549-bsnz24jx	316	7	that	that	WDT
cord-280549-bsnz24jx	316	8	is	be	VBZ
cord-280549-bsnz24jx	316	9	deficient	deficient	JJ
cord-280549-bsnz24jx	316	10	for	for	IN
cord-280549-bsnz24jx	316	11	DDB1	DDB1	NNS
cord-280549-bsnz24jx	316	12	binding	binding	NN
cord-280549-bsnz24jx	316	13	suggests	suggest	VBZ
cord-280549-bsnz24jx	316	14	that	that	IN
cord-280549-bsnz24jx	316	15	this	this	DT
cord-280549-bsnz24jx	316	16	perturbation	perturbation	NN
cord-280549-bsnz24jx	316	17	of	of	IN
cord-280549-bsnz24jx	316	18	cell	cell	NN
cord-280549-bsnz24jx	316	19	cycle	cycle	NN
cord-280549-bsnz24jx	316	20	progression	progression	NN
cord-280549-bsnz24jx	316	21	is	be	VBZ
cord-280549-bsnz24jx	316	22	attributable	attributable	JJ
cord-280549-bsnz24jx	316	23	to	to	IN
cord-280549-bsnz24jx	316	24	the	the	DT
cord-280549-bsnz24jx	316	25	interaction	interaction	NN
cord-280549-bsnz24jx	316	26	of	of	IN
cord-280549-bsnz24jx	316	27	HBx	HBx	NNP
cord-280549-bsnz24jx	316	28	with	with	IN
cord-280549-bsnz24jx	316	29	DDB1	DDB1	NNP
cord-280549-bsnz24jx	316	30	(	(	-LRB-
cord-280549-bsnz24jx	316	31	Leupin	Leupin	NNP
cord-280549-bsnz24jx	316	32	et	et	NNP
cord-280549-bsnz24jx	316	33	al	al	NNP
cord-280549-bsnz24jx	316	34	.	.	NNP
cord-280549-bsnz24jx	316	35	,	,	,
cord-280549-bsnz24jx	316	36	2003	2003	CD
cord-280549-bsnz24jx	316	37	;	;	:
cord-280549-bsnz24jx	316	38	Martin	Martin	NNP
cord-280549-bsnz24jx	316	39	-	-	HYPH
cord-280549-bsnz24jx	316	40	Lluesma	Lluesma	NNP
cord-280549-bsnz24jx	316	41	et	et	FW
cord-280549-bsnz24jx	316	42	al	al	NNP
cord-280549-bsnz24jx	316	43	.	.	NNP
cord-280549-bsnz24jx	316	44	,	,	,
cord-280549-bsnz24jx	316	45	2008	2008	CD
cord-280549-bsnz24jx	316	46	)	)	-RRB-
cord-280549-bsnz24jx	316	47	.	.	.
cord-280549-bsnz24jx	317	1	Phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	317	2	and	and	CC
cord-280549-bsnz24jx	317	3	dephosphorylation	dephosphorylation	NN
cord-280549-bsnz24jx	317	4	govern	govern	VBP
cord-280549-bsnz24jx	317	5	the	the	DT
cord-280549-bsnz24jx	317	6	function	function	NN
cord-280549-bsnz24jx	317	7	of	of	IN
cord-280549-bsnz24jx	317	8	many	many	JJ
cord-280549-bsnz24jx	317	9	cell	cell	NN
cord-280549-bsnz24jx	317	10	cycle	cycle	NN
cord-280549-bsnz24jx	317	11	regulators	regulator	NNS
cord-280549-bsnz24jx	317	12	,	,	,
cord-280549-bsnz24jx	317	13	thus	thus	RB
cord-280549-bsnz24jx	317	14	acting	act	VBG
cord-280549-bsnz24jx	317	15	as	as	IN
cord-280549-bsnz24jx	317	16	switches	switch	NNS
cord-280549-bsnz24jx	317	17	to	to	TO
cord-280549-bsnz24jx	317	18	ensure	ensure	VB
cord-280549-bsnz24jx	317	19	its	-PRON-	PRP$
cord-280549-bsnz24jx	317	20	normal	normal	JJ
cord-280549-bsnz24jx	317	21	progression	progression	NN
cord-280549-bsnz24jx	317	22	.	.	.
cord-280549-bsnz24jx	318	1	For	for	IN
cord-280549-bsnz24jx	318	2	instance	instance	NN
cord-280549-bsnz24jx	318	3	,	,	,
cord-280549-bsnz24jx	318	4	the	the	DT
cord-280549-bsnz24jx	318	5	kinase	kinase	NN
cord-280549-bsnz24jx	318	6	activity	activity	NN
cord-280549-bsnz24jx	318	7	of	of	IN
cord-280549-bsnz24jx	318	8	CDK4	CDK4	NNP
cord-280549-bsnz24jx	318	9	can	can	MD
cord-280549-bsnz24jx	318	10	not	not	RB
cord-280549-bsnz24jx	318	11	be	be	VB
cord-280549-bsnz24jx	318	12	merely	merely	RB
cord-280549-bsnz24jx	318	13	regulated	regulate	VBN
cord-280549-bsnz24jx	318	14	by	by	IN
cord-280549-bsnz24jx	318	15	its	-PRON-	PRP$
cord-280549-bsnz24jx	318	16	association	association	NN
cord-280549-bsnz24jx	318	17	with	with	IN
cord-280549-bsnz24jx	318	18	D	D	NNP
cord-280549-bsnz24jx	318	19	-	-	HYPH
cord-280549-bsnz24jx	318	20	type	type	NN
cord-280549-bsnz24jx	318	21	cyclin	cyclin	NN
cord-280549-bsnz24jx	318	22	.	.	.
cord-280549-bsnz24jx	319	1	CDK4	CDK4	NNP
cord-280549-bsnz24jx	319	2	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	319	3	onThr172	onthr172	RB
cord-280549-bsnz24jx	319	4	by	by	IN
cord-280549-bsnz24jx	319	5	CAK	CAK	NNP
cord-280549-bsnz24jx	319	6	is	be	VBZ
cord-280549-bsnz24jx	319	7	also	also	RB
cord-280549-bsnz24jx	319	8	required	require	VBN
cord-280549-bsnz24jx	319	9	to	to	IN
cord-280549-bsnz24jx	319	10	(	(	-LRB-
cord-280549-bsnz24jx	319	11	Hume	Hume	NNP
cord-280549-bsnz24jx	319	12	et	et	NNP
cord-280549-bsnz24jx	319	13	al	al	NNP
cord-280549-bsnz24jx	319	14	.	.	NNP
cord-280549-bsnz24jx	319	15	,	,	,
cord-280549-bsnz24jx	319	16	2008	2008	CD
cord-280549-bsnz24jx	319	17	)	)	-RRB-
cord-280549-bsnz24jx	319	18	.	.	.
cord-280549-bsnz24jx	320	1	HCMV	HCMV	NNP
cord-280549-bsnz24jx	320	2	IE1	IE1	NNP
cord-280549-bsnz24jx	320	3	-	-	HYPH
cord-280549-bsnz24jx	320	4	72	72	CD
cord-280549-bsnz24jx	320	5	is	be	VBZ
cord-280549-bsnz24jx	320	6	a	a	DT
cord-280549-bsnz24jx	320	7	viral	viral	JJ
cord-280549-bsnz24jx	320	8	protein	protein	NN
cord-280549-bsnz24jx	320	9	kinase	kinase	NN
cord-280549-bsnz24jx	320	10	able	able	JJ
cord-280549-bsnz24jx	320	11	to	to	TO
cord-280549-bsnz24jx	320	12	directly	directly	RB
cord-280549-bsnz24jx	320	13	and	and	CC
cord-280549-bsnz24jx	320	14	selectively	selectively	RB
cord-280549-bsnz24jx	320	15	phosphorylate	phosphorylate	VB
cord-280549-bsnz24jx	320	16	transcription	transcription	NN
cord-280549-bsnz24jx	320	17	factors	factor	NNS
cord-280549-bsnz24jx	320	18	of	of	IN
cord-280549-bsnz24jx	320	19	the	the	DT
cord-280549-bsnz24jx	320	20	E2F	E2F	NNP
cord-280549-bsnz24jx	320	21	family	family	NN
cord-280549-bsnz24jx	320	22	(	(	-LRB-
cord-280549-bsnz24jx	320	23	E2F1,−2	E2F1,−2	NNP
cord-280549-bsnz24jx	320	24	,	,	,
cord-280549-bsnz24jx	320	25	and−3	and−3	NNP
cord-280549-bsnz24jx	320	26	)	)	-RRB-
cord-280549-bsnz24jx	320	27	,	,	,
cord-280549-bsnz24jx	320	28	leading	lead	VBG
cord-280549-bsnz24jx	320	29	to	to	IN
cord-280549-bsnz24jx	320	30	E2F	e2f	JJ
cord-280549-bsnz24jx	320	31	-	-	HYPH
cord-280549-bsnz24jx	320	32	dependent	dependent	JJ
cord-280549-bsnz24jx	320	33	transcriptional	transcriptional	JJ
cord-280549-bsnz24jx	320	34	activation	activation	NN
cord-280549-bsnz24jx	320	35	,	,	,
cord-280549-bsnz24jx	320	36	thus	thus	RB
cord-280549-bsnz24jx	320	37	regulating	regulate	VBG
cord-280549-bsnz24jx	320	38	cell	cell	NN
cord-280549-bsnz24jx	320	39	cycle	cycle	NN
cord-280549-bsnz24jx	320	40	events	event	NNS
cord-280549-bsnz24jx	320	41	(	(	-LRB-
cord-280549-bsnz24jx	320	42	Pajovic	Pajovic	NNP
cord-280549-bsnz24jx	320	43	et	et	FW
cord-280549-bsnz24jx	320	44	al	al	NNP
cord-280549-bsnz24jx	320	45	.	.	NNP
cord-280549-bsnz24jx	320	46	,	,	,
cord-280549-bsnz24jx	320	47	1997	1997	CD
cord-280549-bsnz24jx	320	48	)	)	-RRB-
cord-280549-bsnz24jx	320	49	.	.	.
cord-280549-bsnz24jx	321	1	(	(	-LRB-
cord-280549-bsnz24jx	321	2	B	b	NN
cord-280549-bsnz24jx	321	3	)	)	-RRB-
cord-280549-bsnz24jx	321	4	Expression	expression	NN
cord-280549-bsnz24jx	321	5	of	of	IN
cord-280549-bsnz24jx	321	6	viral	viral	JJ
cord-280549-bsnz24jx	321	7	S1	s1	NN
cord-280549-bsnz24jx	321	8	gene	gene	NN
cord-280549-bsnz24jx	321	9	-	-	HYPH
cord-280549-bsnz24jx	321	10	encoded	encode	VBN
cord-280549-bsnz24jx	321	11	σ1s	σ1s	CD
cord-280549-bsnz24jx	321	12	nonstructural	nonstructural	JJ
cord-280549-bsnz24jx	321	13	protein	protein	NN
cord-280549-bsnz24jx	321	14	during	during	IN
cord-280549-bsnz24jx	321	15	reovirus	reovirus	NNP
cord-280549-bsnz24jx	321	16	infection	infection	NN
cord-280549-bsnz24jx	321	17	leads	lead	VBZ
cord-280549-bsnz24jx	321	18	to	to	IN
cord-280549-bsnz24jx	321	19	G2	G2	NNP
cord-280549-bsnz24jx	321	20	/	/	SYM
cord-280549-bsnz24jx	321	21	M	M	NNP
cord-280549-bsnz24jx	321	22	arrest	arrest	NN
cord-280549-bsnz24jx	321	23	in	in	IN
cord-280549-bsnz24jx	321	24	host	host	NN
cord-280549-bsnz24jx	321	25	cells	cell	NNS
cord-280549-bsnz24jx	321	26	via	via	IN
cord-280549-bsnz24jx	321	27	σ1s	σ1s	CD
cord-280549-bsnz24jx	321	28	-	-	HYPH
cord-280549-bsnz24jx	321	29	mediated	mediate	VBN
cord-280549-bsnz24jx	321	30	CDK1	CDK1	NNP
cord-280549-bsnz24jx	321	31	hyperphosphorylation	hyperphosphorylation	NN
cord-280549-bsnz24jx	322	1	(	(	-LRB-
cord-280549-bsnz24jx	322	2	Poggioli	Poggioli	NNP
cord-280549-bsnz24jx	322	3	et	et	NNP
cord-280549-bsnz24jx	322	4	al	al	NNP
cord-280549-bsnz24jx	322	5	.	.	.
cord-280549-bsnz24jx	323	1	,	,	,
cord-280549-bsnz24jx	323	2	2000	2000	CD
cord-280549-bsnz24jx	323	3	(	(	-LRB-
cord-280549-bsnz24jx	323	4	Poggioli	Poggioli	NNP
cord-280549-bsnz24jx	323	5	et	et	NNP
cord-280549-bsnz24jx	323	6	al	al	NNP
cord-280549-bsnz24jx	323	7	.	.	NNP
cord-280549-bsnz24jx	323	8	,	,	,
cord-280549-bsnz24jx	323	9	,	,	,
cord-280549-bsnz24jx	323	10	2001	2001	CD
cord-280549-bsnz24jx	323	11	.	.	.
cord-280549-bsnz24jx	324	1	Similarly	similarly	RB
cord-280549-bsnz24jx	324	2	,	,	,
cord-280549-bsnz24jx	324	3	human	human	JJ
cord-280549-bsnz24jx	324	4	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	324	5	6	6	CD
cord-280549-bsnz24jx	324	6	(	(	-LRB-
cord-280549-bsnz24jx	324	7	HHV-6)-induces	HHV-6)-induces	NNPS
cord-280549-bsnz24jx	324	8	G2	G2	NNP
cord-280549-bsnz24jx	324	9	/	/	SYM
cord-280549-bsnz24jx	324	10	M	M	NNP
cord-280549-bsnz24jx	324	11	arrest	arrest	NN
cord-280549-bsnz24jx	324	12	by	by	IN
cord-280549-bsnz24jx	324	13	increasing	increase	VBG
cord-280549-bsnz24jx	324	14	the	the	DT
cord-280549-bsnz24jx	324	15	inactive	inactive	JJ
cord-280549-bsnz24jx	324	16	Ser216-phosphorylated	ser216-phosphorylated	NN
cord-280549-bsnz24jx	324	17	form	form	NN
cord-280549-bsnz24jx	325	1	Cdc25C	Cdc25C	NNP
cord-280549-bsnz24jx	325	2	phosphatase	phosphatase	NN
cord-280549-bsnz24jx	325	3	that	that	WDT
cord-280549-bsnz24jx	325	4	accumulates	accumulate	VBZ
cord-280549-bsnz24jx	325	5	in	in	IN
cord-280549-bsnz24jx	325	6	the	the	DT
cord-280549-bsnz24jx	325	7	cytoplasm	cytoplasm	NN
cord-280549-bsnz24jx	325	8	where	where	WRB
cord-280549-bsnz24jx	325	9	it	-PRON-	PRP
cord-280549-bsnz24jx	325	10	has	have	VBZ
cord-280549-bsnz24jx	325	11	no	no	DT
cord-280549-bsnz24jx	325	12	access	access	NN
cord-280549-bsnz24jx	325	13	to	to	IN
cord-280549-bsnz24jx	325	14	its	-PRON-	PRP$
cord-280549-bsnz24jx	325	15	CDK1	CDK1	NNP
cord-280549-bsnz24jx	325	16	substrate	substrate	NN
cord-280549-bsnz24jx	325	17	(	(	-LRB-
cord-280549-bsnz24jx	325	18	Li	Li	NNP
cord-280549-bsnz24jx	325	19	et	et	NNP
cord-280549-bsnz24jx	325	20	al	al	NNP
cord-280549-bsnz24jx	325	21	.	.	NNP
cord-280549-bsnz24jx	325	22	,	,	,
cord-280549-bsnz24jx	325	23	2011	2011	CD
cord-280549-bsnz24jx	325	24	)	)	-RRB-
cord-280549-bsnz24jx	325	25	.	.	.
cord-280549-bsnz24jx	326	1	Members	member	NNS
cord-280549-bsnz24jx	326	2	of	of	IN
cord-280549-bsnz24jx	326	3	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	326	4	share	share	VBP
cord-280549-bsnz24jx	326	5	the	the	DT
cord-280549-bsnz24jx	326	6	conserved	conserved	JJ
cord-280549-bsnz24jx	326	7	UL24	UL24	NNP
cord-280549-bsnz24jx	326	8	family	family	NN
cord-280549-bsnz24jx	326	9	of	of	IN
cord-280549-bsnz24jx	326	10	proteins	protein	NNS
cord-280549-bsnz24jx	326	11	(	(	-LRB-
cord-280549-bsnz24jx	326	12	i.e.	i.e.	FW
cord-280549-bsnz24jx	326	13	,	,	,
cord-280549-bsnz24jx	326	14	UL24	UL24	NNP
cord-280549-bsnz24jx	326	15	,	,	,
cord-280549-bsnz24jx	326	16	ORF20	ORF20	NNP
cord-280549-bsnz24jx	326	17	,	,	,
cord-280549-bsnz24jx	326	18	and	and	CC
cord-280549-bsnz24jx	326	19	UL76	UL76	NNP
cord-280549-bsnz24jx	326	20	)	)	-RRB-
cord-280549-bsnz24jx	326	21	,	,	,
cord-280549-bsnz24jx	326	22	whose	whose	WP$
cord-280549-bsnz24jx	326	23	expression	expression	NN
cord-280549-bsnz24jx	326	24	induces	induce	VBZ
cord-280549-bsnz24jx	326	25	CDK1	CDK1	NNP
cord-280549-bsnz24jx	326	26	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	326	27	at	at	IN
cord-280549-bsnz24jx	326	28	Tyr15	Tyr15	NNP
cord-280549-bsnz24jx	326	29	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	326	30	site	site	NN
cord-280549-bsnz24jx	326	31	with	with	IN
cord-280549-bsnz24jx	326	32	ensuing	ensue	VBG
cord-280549-bsnz24jx	326	33	cell	cell	NN
cord-280549-bsnz24jx	326	34	cycle	cycle	NN
cord-280549-bsnz24jx	326	35	G2	G2	NNP
cord-280549-bsnz24jx	326	36	/	/	SYM
cord-280549-bsnz24jx	326	37	M	M	NNP
cord-280549-bsnz24jx	326	38	arrest	arrest	NN
cord-280549-bsnz24jx	326	39	(	(	-LRB-
cord-280549-bsnz24jx	326	40	Nascimento	Nascimento	NNP
cord-280549-bsnz24jx	326	41	et	et	NNP
cord-280549-bsnz24jx	326	42	al	al	NNP
cord-280549-bsnz24jx	326	43	.	.	NNP
cord-280549-bsnz24jx	326	44	,	,	,
cord-280549-bsnz24jx	326	45	2009	2009	CD
cord-280549-bsnz24jx	326	46	)	)	-RRB-
cord-280549-bsnz24jx	326	47	.	.	.
cord-280549-bsnz24jx	327	1	(	(	-LRB-
cord-280549-bsnz24jx	327	2	C	C	NNP
cord-280549-bsnz24jx	327	3	)	)	-RRB-
cord-280549-bsnz24jx	327	4	HSV-1	hsv-1	VBP
cord-280549-bsnz24jx	327	5	immediate	immediate	JJ
cord-280549-bsnz24jx	327	6	-	-	HYPH
cord-280549-bsnz24jx	327	7	early	early	RB
cord-280549-bsnz24jx	328	1	gene	gene	NN
cord-280549-bsnz24jx	328	2	product	product	NN
cord-280549-bsnz24jx	328	3	ICP0	ICP0	NNP
cord-280549-bsnz24jx	328	4	triggers	trigger	VBZ
cord-280549-bsnz24jx	328	5	a	a	DT
cord-280549-bsnz24jx	328	6	series	series	NN
cord-280549-bsnz24jx	328	7	of	of	IN
cord-280549-bsnz24jx	328	8	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	328	9	events	event	NNS
cord-280549-bsnz24jx	328	10	resulting	result	VBG
cord-280549-bsnz24jx	328	11	in	in	IN
cord-280549-bsnz24jx	328	12	cytoplasmic	cytoplasmic	JJ
cord-280549-bsnz24jx	328	13	sequestration	sequestration	NN
cord-280549-bsnz24jx	328	14	of	of	IN
cord-280549-bsnz24jx	328	15	Cdc25C	Cdc25C	NNP
cord-280549-bsnz24jx	328	16	,	,	,
cord-280549-bsnz24jx	328	17	which	which	WDT
cord-280549-bsnz24jx	328	18	maintains	maintain	VBZ
cord-280549-bsnz24jx	328	19	high	high	JJ
cord-280549-bsnz24jx	328	20	levels	level	NNS
cord-280549-bsnz24jx	328	21	of	of	IN
cord-280549-bsnz24jx	328	22	CDK1	CDK1	NNP
cord-280549-bsnz24jx	328	23	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	328	24	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	328	25	,	,	,
cord-280549-bsnz24jx	328	26	leading	lead	VBG
cord-280549-bsnz24jx	328	27	to	to	IN
cord-280549-bsnz24jx	328	28	CDK1	CDK1	NNP
cord-280549-bsnz24jx	328	29	inactivation	inactivation	NN
cord-280549-bsnz24jx	328	30	with	with	IN
cord-280549-bsnz24jx	328	31	ensuing	ensue	VBG
cord-280549-bsnz24jx	328	32	G2	G2	NNP
cord-280549-bsnz24jx	328	33	/	/	SYM
cord-280549-bsnz24jx	328	34	M	M	NNP
cord-280549-bsnz24jx	328	35	arrest	arrest	NN
cord-280549-bsnz24jx	328	36	.	.	.
cord-280549-bsnz24jx	329	1	catalyze	catalyze	VB
cord-280549-bsnz24jx	329	2	the	the	DT
cord-280549-bsnz24jx	329	3	process	process	NN
cord-280549-bsnz24jx	329	4	.	.	.
cord-280549-bsnz24jx	330	1	As	as	IN
cord-280549-bsnz24jx	330	2	another	another	DT
cord-280549-bsnz24jx	330	3	example	example	NN
cord-280549-bsnz24jx	330	4	,	,	,
cord-280549-bsnz24jx	330	5	the	the	DT
cord-280549-bsnz24jx	330	6	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	330	7	effect	effect	NN
cord-280549-bsnz24jx	330	8	of	of	IN
cord-280549-bsnz24jx	330	9	Rb	Rb	NNP
cord-280549-bsnz24jx	330	10	on	on	IN
cord-280549-bsnz24jx	330	11	transcription	transcription	NN
cord-280549-bsnz24jx	330	12	factor	factor	NN
cord-280549-bsnz24jx	330	13	E2F1is	E2F1is	NNP
cord-280549-bsnz24jx	330	14	suppressed	suppress	VBD
cord-280549-bsnz24jx	330	15	through	through	IN
cord-280549-bsnz24jx	330	16	CDK4/6-mediated	cdk4/6-mediated	CD
cord-280549-bsnz24jx	330	17	hyperphosphorylation	hyperphosphorylation	NN
cord-280549-bsnz24jx	330	18	of	of	IN
cord-280549-bsnz24jx	330	19	Rb	Rb	NNP
cord-280549-bsnz24jx	330	20	(	(	-LRB-
cord-280549-bsnz24jx	330	21	Sidle	sidle	VB
cord-280549-bsnz24jx	330	22	et	et	FW
cord-280549-bsnz24jx	330	23	al	al	NNP
cord-280549-bsnz24jx	330	24	.	.	NNP
cord-280549-bsnz24jx	330	25	,	,	,
cord-280549-bsnz24jx	330	26	1996	1996	CD
cord-280549-bsnz24jx	330	27	)	)	-RRB-
cord-280549-bsnz24jx	330	28	.	.	.
cord-280549-bsnz24jx	331	1	Not	not	RB
cord-280549-bsnz24jx	331	2	surprisingly	surprisingly	RB
cord-280549-bsnz24jx	331	3	,	,	,
cord-280549-bsnz24jx	331	4	viruses	virus	NNS
cord-280549-bsnz24jx	331	5	have	have	VBP
cord-280549-bsnz24jx	331	6	evolved	evolve	VBN
cord-280549-bsnz24jx	331	7	mechanisms	mechanism	NNS
cord-280549-bsnz24jx	331	8	to	to	TO
cord-280549-bsnz24jx	331	9	modulate	modulate	VB
cord-280549-bsnz24jx	331	10	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	331	11	and	and	CC
cord-280549-bsnz24jx	331	12	dephosphorylation	dephosphorylation	NN
cord-280549-bsnz24jx	331	13	events	event	NNS
cord-280549-bsnz24jx	331	14	as	as	IN
cord-280549-bsnz24jx	331	15	additional	additional	JJ
cord-280549-bsnz24jx	331	16	means	mean	NNS
cord-280549-bsnz24jx	331	17	to	to	TO
cord-280549-bsnz24jx	331	18	subvert	subvert	VB
cord-280549-bsnz24jx	331	19	host	host	NN
cord-280549-bsnz24jx	331	20	cell	cell	NN
cord-280549-bsnz24jx	331	21	division	division	NN
cord-280549-bsnz24jx	331	22	cycle	cycle	NN
cord-280549-bsnz24jx	331	23	for	for	IN
cord-280549-bsnz24jx	331	24	their	-PRON-	PRP$
cord-280549-bsnz24jx	331	25	own	own	JJ
cord-280549-bsnz24jx	331	26	benefit	benefit	NN
cord-280549-bsnz24jx	331	27	.	.	.
cord-280549-bsnz24jx	332	1	Direct	direct	JJ
cord-280549-bsnz24jx	332	2	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	332	3	of	of	IN
cord-280549-bsnz24jx	332	4	Rb	Rb	NNP
cord-280549-bsnz24jx	332	5	was	be	VBD
cord-280549-bsnz24jx	332	6	reported	report	VBN
cord-280549-bsnz24jx	332	7	for	for	IN
cord-280549-bsnz24jx	332	8	HCMV	HCMV	NNP
cord-280549-bsnz24jx	332	9	UL97	UL97	NNP
cord-280549-bsnz24jx	332	10	protein	protein	NN
cord-280549-bsnz24jx	332	11	as	as	IN
cord-280549-bsnz24jx	332	12	the	the	DT
cord-280549-bsnz24jx	332	13	first	first	JJ
cord-280549-bsnz24jx	332	14	example	example	NN
cord-280549-bsnz24jx	332	15	of	of	IN
cord-280549-bsnz24jx	332	16	a	a	DT
cord-280549-bsnz24jx	332	17	virus	virus	NN
cord-280549-bsnz24jx	332	18	-	-	HYPH
cord-280549-bsnz24jx	332	19	encoded	encode	VBN
cord-280549-bsnz24jx	332	20	functional	functional	JJ
cord-280549-bsnz24jx	332	21	ortholog	ortholog	NN
cord-280549-bsnz24jx	332	22	of	of	IN
cord-280549-bsnz24jx	332	23	CDK	CDK	NNP
cord-280549-bsnz24jx	332	24	(	(	-LRB-
cord-280549-bsnz24jx	332	25	Hume	Hume	NNP
cord-280549-bsnz24jx	332	26	et	et	NNP
cord-280549-bsnz24jx	332	27	al	al	NNP
cord-280549-bsnz24jx	332	28	.	.	NNP
cord-280549-bsnz24jx	332	29	,	,	,
cord-280549-bsnz24jx	332	30	2008	2008	CD
cord-280549-bsnz24jx	332	31	)	)	-RRB-
cord-280549-bsnz24jx	332	32	.	.	.
cord-280549-bsnz24jx	333	1	As	as	IN
cord-280549-bsnz24jx	333	2	expected	expect	VBN
cord-280549-bsnz24jx	333	3	,	,	,
cord-280549-bsnz24jx	333	4	expression	expression	NN
cord-280549-bsnz24jx	333	5	of	of	IN
cord-280549-bsnz24jx	333	6	mutant	mutant	JJ
cord-280549-bsnz24jx	333	7	UL97	UL97	NNP
cord-280549-bsnz24jx	333	8	in	in	IN
cord-280549-bsnz24jx	333	9	cells	cell	NNS
cord-280549-bsnz24jx	333	10	,	,	,
cord-280549-bsnz24jx	333	11	which	which	WDT
cord-280549-bsnz24jx	333	12	are	be	VBP
cord-280549-bsnz24jx	333	13	intrinsically	intrinsically	RB
cord-280549-bsnz24jx	333	14	deficient	deficient	JJ
cord-280549-bsnz24jx	333	15	in	in	IN
cord-280549-bsnz24jx	333	16	the	the	DT
cord-280549-bsnz24jx	333	17	ability	ability	NN
cord-280549-bsnz24jx	333	18	to	to	TO
cord-280549-bsnz24jx	333	19	phosphorylate	phosphorylate	VB
cord-280549-bsnz24jx	333	20	Rb	Rb	NNP
cord-280549-bsnz24jx	333	21	,	,	,
cord-280549-bsnz24jx	333	22	induces	induce	VBZ
cord-280549-bsnz24jx	333	23	Rb	Rb	NNP
cord-280549-bsnz24jx	333	24	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	333	25	on	on	IN
cord-280549-bsnz24jx	333	26	the	the	DT
cord-280549-bsnz24jx	333	27	inactivating	inactivate	VBG
cord-280549-bsnz24jx	333	28	residues	residue	NNS
cord-280549-bsnz24jx	333	29	.	.	.
cord-280549-bsnz24jx	334	1	Moreover	moreover	RB
cord-280549-bsnz24jx	334	2	,	,	,
cord-280549-bsnz24jx	334	3	UL97	UL97	NNP
cord-280549-bsnz24jx	334	4	rescues	rescue	VBZ
cord-280549-bsnz24jx	334	5	the	the	DT
cord-280549-bsnz24jx	334	6	proliferation	proliferation	NN
cord-280549-bsnz24jx	334	7	of	of	IN
cord-280549-bsnz24jx	334	8	a	a	DT
cord-280549-bsnz24jx	334	9	yeast	yeast	NN
cord-280549-bsnz24jx	334	10	mutant	mutant	NN
cord-280549-bsnz24jx	334	11	which	which	WDT
cord-280549-bsnz24jx	334	12	lacks	lack	VBZ
cord-280549-bsnz24jx	334	13	CDK	CDK	NNP
cord-280549-bsnz24jx	334	14	activity	activity	NN
cord-280549-bsnz24jx	334	15	,	,	,
cord-280549-bsnz24jx	334	16	suggesting	suggest	VBG
cord-280549-bsnz24jx	334	17	UL97	UL97	NNP
cord-280549-bsnz24jx	334	18	functions	function	NNS
cord-280549-bsnz24jx	334	19	similar	similar	JJ
cord-280549-bsnz24jx	334	20	to	to	IN
cord-280549-bsnz24jx	334	21	CDK	CDK	NNP
cord-280549-bsnz24jx	334	22	.	.	.
cord-280549-bsnz24jx	335	1	Sequence	sequence	NN
cord-280549-bsnz24jx	335	2	comparison	comparison	NN
cord-280549-bsnz24jx	335	3	between	between	IN
cord-280549-bsnz24jx	335	4	CDK	CDK	NNP
cord-280549-bsnz24jx	335	5	and	and	CC
cord-280549-bsnz24jx	335	6	UL97	UL97	NNP
cord-280549-bsnz24jx	335	7	revealed	reveal	VBD
cord-280549-bsnz24jx	335	8	that	that	IN
cord-280549-bsnz24jx	335	9	this	this	DT
cord-280549-bsnz24jx	335	10	viral	viral	JJ
cord-280549-bsnz24jx	335	11	protein	protein	NN
cord-280549-bsnz24jx	335	12	does	do	VBZ
cord-280549-bsnz24jx	335	13	not	not	RB
cord-280549-bsnz24jx	335	14	require	require	VB
cord-280549-bsnz24jx	335	15	cyclin	cyclin	NN
cord-280549-bsnz24jx	335	16	binding	bind	VBG
cord-280549-bsnz24jx	335	17	for	for	IN
cord-280549-bsnz24jx	335	18	kinase	kinase	NN
cord-280549-bsnz24jx	335	19	activity	activity	NN
cord-280549-bsnz24jx	335	20	and	and	CC
cord-280549-bsnz24jx	335	21	,	,	,
cord-280549-bsnz24jx	335	22	therefore	therefore	RB
cord-280549-bsnz24jx	335	23	,	,	,
cord-280549-bsnz24jx	335	24	is	be	VBZ
cord-280549-bsnz24jx	335	25	resistant	resistant	JJ
cord-280549-bsnz24jx	335	26	to	to	IN
cord-280549-bsnz24jx	335	27	the	the	DT
cord-280549-bsnz24jx	335	28	inhibition	inhibition	NN
cord-280549-bsnz24jx	335	29	of	of	IN
cord-280549-bsnz24jx	335	30	p21	p21	NN
cord-280549-bsnz24jx	335	31	WAF1	WAF1	NNP
cord-280549-bsnz24jx	335	32	/	/	SYM
cord-280549-bsnz24jx	335	33	CIP1	CIP1	NNP
cord-280549-bsnz24jx	335	34	,	,	,
cord-280549-bsnz24jx	335	35	features	feature	VBZ
cord-280549-bsnz24jx	335	36	which	which	WDT
cord-280549-bsnz24jx	335	37	shield	shield	VBP
cord-280549-bsnz24jx	335	38	UL97	UL97	NNP
cord-280549-bsnz24jx	335	39	from	from	IN
cord-280549-bsnz24jx	335	40	the	the	DT
cord-280549-bsnz24jx	335	41	normal	normal	JJ
cord-280549-bsnz24jx	335	42	cellular	cellular	JJ
cord-280549-bsnz24jx	335	43	control	control	NN
cord-280549-bsnz24jx	335	44	mechanisms	mechanism	NNS
cord-280549-bsnz24jx	335	45	that	that	WDT
cord-280549-bsnz24jx	335	46	could	could	MD
cord-280549-bsnz24jx	335	47	attenuate	attenuate	VB
cord-280549-bsnz24jx	335	48	CDK	CDK	NNP
cord-280549-bsnz24jx	335	49	activity	activity	NN
cord-280549-bsnz24jx	335	50	(	(	-LRB-
cord-280549-bsnz24jx	335	51	Hume	Hume	NNP
cord-280549-bsnz24jx	335	52	et	et	NNP
cord-280549-bsnz24jx	335	53	al	al	NNP
cord-280549-bsnz24jx	335	54	.	.	NNP
cord-280549-bsnz24jx	335	55	,	,	,
cord-280549-bsnz24jx	335	56	2008	2008	CD
cord-280549-bsnz24jx	335	57	)	)	-RRB-
cord-280549-bsnz24jx	335	58	.	.	.
cord-280549-bsnz24jx	336	1	HCMV	HCMV	NNP
cord-280549-bsnz24jx	336	2	IE1	IE1	NNP
cord-280549-bsnz24jx	336	3	-	-	HYPH
cord-280549-bsnz24jx	336	4	72	72	CD
cord-280549-bsnz24jx	336	5	is	be	VBZ
cord-280549-bsnz24jx	336	6	a	a	DT
cord-280549-bsnz24jx	336	7	viral	viral	JJ
cord-280549-bsnz24jx	336	8	protein	protein	NN
cord-280549-bsnz24jx	336	9	kinase	kinase	NN
cord-280549-bsnz24jx	336	10	,	,	,
cord-280549-bsnz24jx	336	11	which	which	WDT
cord-280549-bsnz24jx	336	12	is	be	VBZ
cord-280549-bsnz24jx	336	13	able	able	JJ
cord-280549-bsnz24jx	336	14	to	to	TO
cord-280549-bsnz24jx	336	15	directly	directly	RB
cord-280549-bsnz24jx	336	16	and	and	CC
cord-280549-bsnz24jx	336	17	selectively	selectively	RB
cord-280549-bsnz24jx	336	18	phosphorylate	phosphorylate	VB
cord-280549-bsnz24jx	336	19	transcription	transcription	NN
cord-280549-bsnz24jx	336	20	factors	factor	NNS
cord-280549-bsnz24jx	336	21	of	of	IN
cord-280549-bsnz24jx	336	22	the	the	DT
cord-280549-bsnz24jx	336	23	E2F	E2F	NNP
cord-280549-bsnz24jx	336	24	family	family	NN
cord-280549-bsnz24jx	336	25	(	(	-LRB-
cord-280549-bsnz24jx	336	26	E2F1,−2	E2F1,−2	NNP
cord-280549-bsnz24jx	336	27	,	,	,
cord-280549-bsnz24jx	336	28	and−3	and−3	NNP
cord-280549-bsnz24jx	336	29	)	)	-RRB-
cord-280549-bsnz24jx	336	30	and	and	CC
cord-280549-bsnz24jx	336	31	pocket	pocket	NN
cord-280549-bsnz24jx	336	32	proteins	protein	NNS
cord-280549-bsnz24jx	336	33	(	(	-LRB-
cord-280549-bsnz24jx	336	34	p107	p107	NNP
cord-280549-bsnz24jx	336	35	and	and	CC
cord-280549-bsnz24jx	336	36	p130	p130	NNS
cord-280549-bsnz24jx	336	37	)	)	-RRB-
cord-280549-bsnz24jx	337	1	(	(	-LRB-
cord-280549-bsnz24jx	337	2	Pajovic	Pajovic	NNP
cord-280549-bsnz24jx	337	3	et	et	FW
cord-280549-bsnz24jx	337	4	al	al	NNP
cord-280549-bsnz24jx	337	5	.	.	NNP
cord-280549-bsnz24jx	337	6	,	,	,
cord-280549-bsnz24jx	337	7	1997	1997	CD
cord-280549-bsnz24jx	337	8	)	)	-RRB-
cord-280549-bsnz24jx	337	9	.	.	.
cord-280549-bsnz24jx	338	1	Its	-PRON-	PRP$
cord-280549-bsnz24jx	338	2	kinase	kinase	NN
cord-280549-bsnz24jx	338	3	activity	activity	NN
cord-280549-bsnz24jx	338	4	is	be	VBZ
cord-280549-bsnz24jx	338	5	required	require	VBN
cord-280549-bsnz24jx	338	6	for	for	IN
cord-280549-bsnz24jx	338	7	IE1	ie1	NN
cord-280549-bsnz24jx	338	8	-	-	HYPH
cord-280549-bsnz24jx	338	9	72-mediatedformation	72-mediatedformation	CD
cord-280549-bsnz24jx	338	10	and/or	and/or	CC
cord-280549-bsnz24jx	338	11	dissociation	dissociation	NN
cord-280549-bsnz24jx	338	12	of	of	IN
cord-280549-bsnz24jx	338	13	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	338	14	complexes	complex	NNS
cord-280549-bsnz24jx	338	15	that	that	WDT
cord-280549-bsnz24jx	338	16	lead	lead	VBP
cord-280549-bsnz24jx	338	17	to	to	IN
cord-280549-bsnz24jx	338	18	E2F	e2f	JJ
cord-280549-bsnz24jx	338	19	-	-	HYPH
cord-280549-bsnz24jx	338	20	dependent	dependent	JJ
cord-280549-bsnz24jx	338	21	transcriptional	transcriptional	JJ
cord-280549-bsnz24jx	338	22	activation	activation	NN
cord-280549-bsnz24jx	338	23	,	,	,
cord-280549-bsnz24jx	338	24	thus	thus	RB
cord-280549-bsnz24jx	338	25	regulating	regulate	VBG
cord-280549-bsnz24jx	338	26	cell	cell	NN
cord-280549-bsnz24jx	338	27	cycle	cycle	NN
cord-280549-bsnz24jx	338	28	events	event	NNS
cord-280549-bsnz24jx	338	29	(	(	-LRB-
cord-280549-bsnz24jx	338	30	Pajovic	Pajovic	NNP
cord-280549-bsnz24jx	338	31	et	et	FW
cord-280549-bsnz24jx	338	32	al	al	NNP
cord-280549-bsnz24jx	338	33	.	.	NNP
cord-280549-bsnz24jx	338	34	,	,	,
cord-280549-bsnz24jx	338	35	1997	1997	CD
cord-280549-bsnz24jx	338	36	)	)	-RRB-
cord-280549-bsnz24jx	338	37	.	.	.
cord-280549-bsnz24jx	339	1	It	-PRON-	PRP
cord-280549-bsnz24jx	339	2	is	be	VBZ
cord-280549-bsnz24jx	339	3	interesting	interesting	JJ
cord-280549-bsnz24jx	339	4	to	to	TO
cord-280549-bsnz24jx	339	5	note	note	VB
cord-280549-bsnz24jx	339	6	that	that	IN
cord-280549-bsnz24jx	339	7	the	the	DT
cord-280549-bsnz24jx	339	8	kinase	kinase	NN
cord-280549-bsnz24jx	339	9	activity	activity	NN
cord-280549-bsnz24jx	339	10	of	of	IN
cord-280549-bsnz24jx	339	11	IE1	ie1	NN
cord-280549-bsnz24jx	339	12	-	-	HYPH
cord-280549-bsnz24jx	339	13	72	72	CD
cord-280549-bsnz24jx	339	14	resides	reside	NNS
cord-280549-bsnz24jx	339	15	in	in	IN
cord-280549-bsnz24jx	339	16	the	the	DT
cord-280549-bsnz24jx	339	17	portion	portion	NN
cord-280549-bsnz24jx	339	18	encoded	encode	VBN
cord-280549-bsnz24jx	339	19	by	by	IN
cord-280549-bsnz24jx	339	20	exon	exon	NN
cord-280549-bsnz24jx	339	21	4	4	CD
cord-280549-bsnz24jx	339	22	,	,	,
cord-280549-bsnz24jx	339	23	which	which	WDT
cord-280549-bsnz24jx	339	24	is	be	VBZ
cord-280549-bsnz24jx	339	25	not	not	RB
cord-280549-bsnz24jx	339	26	the	the	DT
cord-280549-bsnz24jx	339	27	same	same	JJ
cord-280549-bsnz24jx	339	28	region	region	NN
cord-280549-bsnz24jx	339	29	necessary	necessary	JJ
cord-280549-bsnz24jx	339	30	for	for	IN
cord-280549-bsnz24jx	339	31	its	-PRON-	PRP$
cord-280549-bsnz24jx	339	32	binding	binding	NN
cord-280549-bsnz24jx	339	33	to	to	IN
cord-280549-bsnz24jx	339	34	p107	p107	NNP
cord-280549-bsnz24jx	339	35	(	(	-LRB-
cord-280549-bsnz24jx	339	36	encoded	encode	VBN
cord-280549-bsnz24jx	339	37	by	by	IN
cord-280549-bsnz24jx	339	38	exon	exon	NN
cord-280549-bsnz24jx	339	39	3	3	CD
cord-280549-bsnz24jx	339	40	)	)	-RRB-
cord-280549-bsnz24jx	339	41	as	as	IN
cord-280549-bsnz24jx	339	42	mentioned	mention	VBN
cord-280549-bsnz24jx	339	43	above	above	RB
cord-280549-bsnz24jx	339	44	(	(	-LRB-
cord-280549-bsnz24jx	339	45	Johnson	Johnson	NNP
cord-280549-bsnz24jx	339	46	et	et	NNP
cord-280549-bsnz24jx	339	47	al	al	NNP
cord-280549-bsnz24jx	339	48	.	.	NNP
cord-280549-bsnz24jx	339	49	,	,	,
cord-280549-bsnz24jx	339	50	1999	1999	CD
cord-280549-bsnz24jx	339	51	)	)	-RRB-
cord-280549-bsnz24jx	339	52	.	.	.
cord-280549-bsnz24jx	340	1	It	-PRON-	PRP
cord-280549-bsnz24jx	340	2	is	be	VBZ
cord-280549-bsnz24jx	340	3	possible	possible	JJ
cord-280549-bsnz24jx	340	4	that	that	IN
cord-280549-bsnz24jx	340	5	this	this	DT
cord-280549-bsnz24jx	340	6	interaction	interaction	NN
cord-280549-bsnz24jx	340	7	functions	function	NNS
cord-280549-bsnz24jx	340	8	as	as	IN
cord-280549-bsnz24jx	340	9	the	the	DT
cord-280549-bsnz24jx	340	10	first	first	JJ
cord-280549-bsnz24jx	340	11	step	step	NN
cord-280549-bsnz24jx	340	12	to	to	TO
cord-280549-bsnz24jx	340	13	bridge	bridge	VB
cord-280549-bsnz24jx	340	14	IE1	IE1	NNP
cord-280549-bsnz24jx	340	15	-	-	:
cord-280549-bsnz24jx	340	16	72	72	CD
cord-280549-bsnz24jx	340	17	to	to	IN
cord-280549-bsnz24jx	340	18	its	-PRON-	PRP$
cord-280549-bsnz24jx	340	19	target	target	NN
cord-280549-bsnz24jx	340	20	for	for	IN
cord-280549-bsnz24jx	340	21	later	later	JJ
cord-280549-bsnz24jx	340	22	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	340	23	,	,	,
cord-280549-bsnz24jx	340	24	or	or	CC
cord-280549-bsnz24jx	340	25	that	that	IN
cord-280549-bsnz24jx	340	26	IE1	ie1	NN
cord-280549-bsnz24jx	340	27	-	-	HYPH
cord-280549-bsnz24jx	340	28	72	72	NNP
cord-280549-bsnz24jx	340	29	can	can	MD
cord-280549-bsnz24jx	340	30	independently	independently	RB
cord-280549-bsnz24jx	340	31	exert	exert	VB
cord-280549-bsnz24jx	340	32	its	-PRON-	PRP$
cord-280549-bsnz24jx	340	33	role	role	NN
cord-280549-bsnz24jx	340	34	in	in	IN
cord-280549-bsnz24jx	340	35	cell	cell	NN
cord-280549-bsnz24jx	340	36	cycle	cycle	NN
cord-280549-bsnz24jx	340	37	regulation	regulation	NN
cord-280549-bsnz24jx	340	38	through	through	IN
cord-280549-bsnz24jx	340	39	either	either	DT
cord-280549-bsnz24jx	340	40	physical	physical	JJ
cord-280549-bsnz24jx	340	41	interaction	interaction	NN
cord-280549-bsnz24jx	340	42	or	or	CC
cord-280549-bsnz24jx	340	43	its	-PRON-	PRP$
cord-280549-bsnz24jx	340	44	kinase	kinase	NN
cord-280549-bsnz24jx	340	45	activity	activity	NN
cord-280549-bsnz24jx	340	46	.	.	.
cord-280549-bsnz24jx	341	1	Reovirus	reovirus	JJ
cord-280549-bsnz24jx	341	2	infection	infection	NN
cord-280549-bsnz24jx	341	3	and	and	CC
cord-280549-bsnz24jx	341	4	the	the	DT
cord-280549-bsnz24jx	341	5	sole	sole	JJ
cord-280549-bsnz24jx	341	6	expression	expression	NN
cord-280549-bsnz24jx	341	7	of	of	IN
cord-280549-bsnz24jx	341	8	viral	viral	JJ
cord-280549-bsnz24jx	341	9	S1	s1	NN
cord-280549-bsnz24jx	341	10	geneencoded	geneencode	VBD
cord-280549-bsnz24jx	341	11	σ1s	σ1s	CD
cord-280549-bsnz24jx	341	12	nonstructural	nonstructural	JJ
cord-280549-bsnz24jx	341	13	protein	protein	NN
cord-280549-bsnz24jx	341	14	could	could	MD
cord-280549-bsnz24jx	341	15	lead	lead	VB
cord-280549-bsnz24jx	341	16	to	to	IN
cord-280549-bsnz24jx	341	17	G2	G2	NNP
cord-280549-bsnz24jx	341	18	/	/	SYM
cord-280549-bsnz24jx	341	19	M	M	NNP
cord-280549-bsnz24jx	341	20	arrest	arrest	NN
cord-280549-bsnz24jx	341	21	in	in	IN
cord-280549-bsnz24jx	341	22	host	host	NN
cord-280549-bsnz24jx	341	23	celosia	celosia	NNP
cord-280549-bsnz24jx	341	24	σ1s	σ1s	NNPS
cord-280549-bsnz24jx	341	25	-	-	HYPH
cord-280549-bsnz24jx	341	26	mediated	mediate	VBN
cord-280549-bsnz24jx	341	27	CDK1	CDK1	NNP
cord-280549-bsnz24jx	341	28	hyperphosphorylation	hyperphosphorylation	NN
cord-280549-bsnz24jx	341	29	as	as	IN
cord-280549-bsnz24jx	341	30	revealed	reveal	VBN
cord-280549-bsnz24jx	341	31	with	with	IN
cord-280549-bsnz24jx	341	32	the	the	DT
cord-280549-bsnz24jx	341	33	use	use	NN
cord-280549-bsnz24jx	341	34	of	of	IN
cord-280549-bsnz24jx	341	35	σ1s	σ1s	JJ
cord-280549-bsnz24jx	341	36	-	-	HYPH
cord-280549-bsnz24jx	341	37	mutant	mutant	JJ
cord-280549-bsnz24jx	341	38	virus	virus	NN
cord-280549-bsnz24jx	342	1	(	(	-LRB-
cord-280549-bsnz24jx	342	2	Poggioli	Poggioli	NNP
cord-280549-bsnz24jx	342	3	et	et	NNP
cord-280549-bsnz24jx	342	4	al	al	NNP
cord-280549-bsnz24jx	342	5	.	.	.
cord-280549-bsnz24jx	343	1	,	,	,
cord-280549-bsnz24jx	343	2	2000	2000	CD
cord-280549-bsnz24jx	344	1	(	(	-LRB-
cord-280549-bsnz24jx	344	2	Poggioli	Poggioli	NNP
cord-280549-bsnz24jx	344	3	et	et	NNP
cord-280549-bsnz24jx	344	4	al	al	NNP
cord-280549-bsnz24jx	344	5	.	.	NNP
cord-280549-bsnz24jx	344	6	,	,	,
cord-280549-bsnz24jx	344	7	,	,	,
cord-280549-bsnz24jx	344	8	2001	2001	CD
cord-280549-bsnz24jx	344	9	.	.	.
cord-280549-bsnz24jx	345	1	It	-PRON-	PRP
cord-280549-bsnz24jx	345	2	was	be	VBD
cord-280549-bsnz24jx	345	3	reported	report	VBN
cord-280549-bsnz24jx	345	4	that	that	IN
cord-280549-bsnz24jx	345	5	the	the	DT
cord-280549-bsnz24jx	345	6	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	345	7	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	345	8	of	of	IN
cord-280549-bsnz24jx	345	9	CDK1	CDK1	NNP
cord-280549-bsnz24jx	345	10	by	by	IN
cord-280549-bsnz24jx	345	11	reovirus	reovirus	NNP
cord-280549-bsnz24jx	345	12	decreased	decrease	VBD
cord-280549-bsnz24jx	345	13	the	the	DT
cord-280549-bsnz24jx	345	14	hyperphosphorylated	hyperphosphorylate	VBN
cord-280549-bsnz24jx	345	15	form	form	NN
cord-280549-bsnz24jx	345	16	(	(	-LRB-
cord-280549-bsnz24jx	345	17	active	active	JJ
cord-280549-bsnz24jx	345	18	form	form	NN
cord-280549-bsnz24jx	345	19	)	)	-RRB-
cord-280549-bsnz24jx	345	20	of	of	IN
cord-280549-bsnz24jx	345	21	Cdc25C	Cdc25C	NNP
cord-280549-bsnz24jx	345	22	,	,	,
cord-280549-bsnz24jx	345	23	the	the	DT
cord-280549-bsnz24jx	345	24	CDK1-specific	CDK1-specific	NNP
cord-280549-bsnz24jx	345	25	phosphatase	phosphatase	NN
cord-280549-bsnz24jx	345	26	(	(	-LRB-
cord-280549-bsnz24jx	345	27	Poggioli	Poggioli	NNP
cord-280549-bsnz24jx	345	28	et	et	NNP
cord-280549-bsnz24jx	345	29	al	al	NNP
cord-280549-bsnz24jx	345	30	.	.	NNP
cord-280549-bsnz24jx	345	31	,	,	,
cord-280549-bsnz24jx	345	32	2001	2001	CD
cord-280549-bsnz24jx	345	33	)	)	-RRB-
cord-280549-bsnz24jx	345	34	,	,	,
cord-280549-bsnz24jx	345	35	hence	hence	RB
cord-280549-bsnz24jx	345	36	preventing	prevent	VBG
cord-280549-bsnz24jx	345	37	CDK1	CDK1	NNP
cord-280549-bsnz24jx	345	38	dephosphorylation	dephosphorylation	NN
cord-280549-bsnz24jx	345	39	,	,	,
cord-280549-bsnz24jx	345	40	an	an	DT
cord-280549-bsnz24jx	345	41	absolute	absolute	JJ
cord-280549-bsnz24jx	345	42	requirement	requirement	NN
cord-280549-bsnz24jx	345	43	for	for	IN
cord-280549-bsnz24jx	345	44	the	the	DT
cord-280549-bsnz24jx	345	45	onset	onset	NN
cord-280549-bsnz24jx	345	46	of	of	IN
cord-280549-bsnz24jx	345	47	mitosis	mitosis	NN
cord-280549-bsnz24jx	346	1	(	(	-LRB-
cord-280549-bsnz24jx	346	2	Jin	Jin	NNP
cord-280549-bsnz24jx	346	3	et	et	NNP
cord-280549-bsnz24jx	346	4	al	al	NNP
cord-280549-bsnz24jx	346	5	.	.	NNP
cord-280549-bsnz24jx	346	6	,	,	,
cord-280549-bsnz24jx	346	7	1996	1996	CD
cord-280549-bsnz24jx	346	8	)	)	-RRB-
cord-280549-bsnz24jx	346	9	.	.	.
cord-280549-bsnz24jx	347	1	Similarly	similarly	RB
cord-280549-bsnz24jx	347	2	,	,	,
cord-280549-bsnz24jx	347	3	human	human	JJ
cord-280549-bsnz24jx	347	4	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	347	5	6	6	CD
cord-280549-bsnz24jx	347	6	(	(	-LRB-
cord-280549-bsnz24jx	347	7	HHV-6)-induced	HHV-6)-induced	NNP
cord-280549-bsnz24jx	347	8	G2	G2	NNP
cord-280549-bsnz24jx	347	9	/	/	SYM
cord-280549-bsnz24jx	347	10	M	M	NNP
cord-280549-bsnz24jx	347	11	arrest	arrest	NN
cord-280549-bsnz24jx	347	12	correlates	correlate	VBZ
cord-280549-bsnz24jx	347	13	with	with	IN
cord-280549-bsnz24jx	347	14	enhanced	enhanced	JJ
cord-280549-bsnz24jx	347	15	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	347	16	of	of	IN
cord-280549-bsnz24jx	347	17	CDK1	CDK1	NNP
cord-280549-bsnz24jx	347	18	at	at	IN
cord-280549-bsnz24jx	347	19	the	the	DT
cord-280549-bsnz24jx	347	20	Tyr15	Tyr15	NNP
cord-280549-bsnz24jx	347	21	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	347	22	site	site	NN
cord-280549-bsnz24jx	347	23	.	.	.
cord-280549-bsnz24jx	348	1	This	this	DT
cord-280549-bsnz24jx	348	2	is	be	VBZ
cord-280549-bsnz24jx	348	3	achieved	achieve	VBN
cord-280549-bsnz24jx	348	4	through	through	IN
cord-280549-bsnz24jx	348	5	both	both	CC
cord-280549-bsnz24jx	348	6	elevating	elevate	VBG
cord-280549-bsnz24jx	348	7	the	the	DT
cord-280549-bsnz24jx	348	8	level	level	NN
cord-280549-bsnz24jx	348	9	of	of	IN
cord-280549-bsnz24jx	348	10	the	the	DT
cord-280549-bsnz24jx	348	11	negative	negative	JJ
cord-280549-bsnz24jx	348	12	regulator	regulator	NN
cord-280549-bsnz24jx	348	13	Wee1	Wee1	NNP
cord-280549-bsnz24jx	348	14	and	and	CC
cord-280549-bsnz24jx	348	15	inhibiting	inhibit	VBG
cord-280549-bsnz24jx	348	16	the	the	DT
cord-280549-bsnz24jx	348	17	activity	activity	NN
cord-280549-bsnz24jx	348	18	of	of	IN
cord-280549-bsnz24jx	348	19	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	348	20	phosphatase	phosphatase	NN
cord-280549-bsnz24jx	348	21	by	by	IN
cord-280549-bsnz24jx	348	22	increasing	increase	VBG
cord-280549-bsnz24jx	348	23	the	the	DT
cord-280549-bsnz24jx	348	24	inactive	inactive	JJ
cord-280549-bsnz24jx	348	25	Ser216-phosphorylated	ser216-phosphorylated	NN
cord-280549-bsnz24jx	348	26	form	form	NN
cord-280549-bsnz24jx	348	27	that	that	WDT
cord-280549-bsnz24jx	348	28	accumulates	accumulate	VBZ
cord-280549-bsnz24jx	348	29	in	in	IN
cord-280549-bsnz24jx	348	30	the	the	DT
cord-280549-bsnz24jx	348	31	cytoplasm	cytoplasm	NN
cord-280549-bsnz24jx	348	32	where	where	WRB
cord-280549-bsnz24jx	348	33	it	-PRON-	PRP
cord-280549-bsnz24jx	348	34	has	have	VBZ
cord-280549-bsnz24jx	348	35	no	no	DT
cord-280549-bsnz24jx	348	36	access	access	NN
cord-280549-bsnz24jx	348	37	to	to	IN
cord-280549-bsnz24jx	348	38	its	-PRON-	PRP$
cord-280549-bsnz24jx	348	39	CDK1	CDK1	NNP
cord-280549-bsnz24jx	348	40	substrate	substrate	NN
cord-280549-bsnz24jx	348	41	(	(	-LRB-
cord-280549-bsnz24jx	348	42	Li	Li	NNP
cord-280549-bsnz24jx	348	43	et	et	NNP
cord-280549-bsnz24jx	348	44	al	al	NNP
cord-280549-bsnz24jx	348	45	.	.	NNP
cord-280549-bsnz24jx	348	46	,	,	,
cord-280549-bsnz24jx	348	47	2011	2011	CD
cord-280549-bsnz24jx	348	48	)	)	-RRB-
cord-280549-bsnz24jx	348	49	.	.	.
cord-280549-bsnz24jx	349	1	Members	member	NNS
cord-280549-bsnz24jx	349	2	of	of	IN
cord-280549-bsnz24jx	349	3	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	349	4	share	share	VBP
cord-280549-bsnz24jx	349	5	the	the	DT
cord-280549-bsnz24jx	349	6	conserved	conserved	JJ
cord-280549-bsnz24jx	349	7	UL24	UL24	NNP
cord-280549-bsnz24jx	349	8	family	family	NN
cord-280549-bsnz24jx	349	9	of	of	IN
cord-280549-bsnz24jx	349	10	proteins	protein	NNS
cord-280549-bsnz24jx	349	11	,	,	,
cord-280549-bsnz24jx	349	12	namely	namely	RB
cord-280549-bsnz24jx	349	13	UL24	UL24	VBN
cord-280549-bsnz24jx	349	14	in	in	IN
cord-280549-bsnz24jx	349	15	herpes	herpes	NNP
cord-280549-bsnz24jx	349	16	simplex	simplex	NNP
cord-280549-bsnz24jx	349	17	virus	virus	NN
cord-280549-bsnz24jx	349	18	type	type	NN
cord-280549-bsnz24jx	349	19	1	1	CD
cord-280549-bsnz24jx	349	20	(	(	-LRB-
cord-280549-bsnz24jx	349	21	HSV-1	HSV-1	NNP
cord-280549-bsnz24jx	349	22	)	)	-RRB-
cord-280549-bsnz24jx	349	23	,	,	,
cord-280549-bsnz24jx	349	24	ORF20	orf20	ADD
cord-280549-bsnz24jx	350	1	in	in	IN
cord-280549-bsnz24jx	350	2	KSHV	KSHV	NNP
cord-280549-bsnz24jx	350	3	,	,	,
cord-280549-bsnz24jx	350	4	and	and	CC
cord-280549-bsnz24jx	350	5	UL76	UL76	NNP
cord-280549-bsnz24jx	350	6	in	in	IN
cord-280549-bsnz24jx	350	7	HCMV	HCMV	NNP
cord-280549-bsnz24jx	350	8	.	.	.
cord-280549-bsnz24jx	351	1	Expression	expression	NN
cord-280549-bsnz24jx	351	2	of	of	IN
cord-280549-bsnz24jx	351	3	these	these	DT
cord-280549-bsnz24jx	351	4	UL24	ul24	JJ
cord-280549-bsnz24jx	351	5	proteins	protein	NNS
cord-280549-bsnz24jx	351	6	led	lead	VBD
cord-280549-bsnz24jx	351	7	to	to	IN
cord-280549-bsnz24jx	351	8	CDK1	CDK1	NNP
cord-280549-bsnz24jx	351	9	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	351	10	at	at	IN
cord-280549-bsnz24jx	351	11	Tyr15	Tyr15	NNP
cord-280549-bsnz24jx	351	12	,	,	,
cord-280549-bsnz24jx	352	1	the	the	DT
cord-280549-bsnz24jx	352	2	dephosphorylation	dephosphorylation	NN
cord-280549-bsnz24jx	352	3	of	of	IN
cord-280549-bsnz24jx	352	4	which	which	WDT
cord-280549-bsnz24jx	352	5	is	be	VBZ
cord-280549-bsnz24jx	352	6	required	require	VBN
cord-280549-bsnz24jx	352	7	for	for	IN
cord-280549-bsnz24jx	352	8	the	the	DT
cord-280549-bsnz24jx	352	9	initiation	initiation	NN
cord-280549-bsnz24jx	352	10	of	of	IN
cord-280549-bsnz24jx	352	11	mitosis	mitosis	NN
cord-280549-bsnz24jx	353	1	(	(	-LRB-
cord-280549-bsnz24jx	353	2	Jin	Jin	NNP
cord-280549-bsnz24jx	353	3	et	et	NNP
cord-280549-bsnz24jx	353	4	al	al	NNP
cord-280549-bsnz24jx	353	5	.	.	NNP
cord-280549-bsnz24jx	353	6	,	,	,
cord-280549-bsnz24jx	353	7	1996	1996	CD
cord-280549-bsnz24jx	353	8	)	)	-RRB-
cord-280549-bsnz24jx	353	9	,	,	,
cord-280549-bsnz24jx	353	10	with	with	IN
cord-280549-bsnz24jx	353	11	ensuing	ensue	VBG
cord-280549-bsnz24jx	353	12	cell	cell	NN
cord-280549-bsnz24jx	353	13	cycle	cycle	NN
cord-280549-bsnz24jx	353	14	G2	G2	NNP
cord-280549-bsnz24jx	353	15	/	/	SYM
cord-280549-bsnz24jx	353	16	M	M	NNP
cord-280549-bsnz24jx	353	17	arrest	arrest	NN
cord-280549-bsnz24jx	353	18	(	(	-LRB-
cord-280549-bsnz24jx	353	19	Nascimento	Nascimento	NNP
cord-280549-bsnz24jx	353	20	et	et	NNP
cord-280549-bsnz24jx	353	21	al	al	NNP
cord-280549-bsnz24jx	353	22	.	.	NNP
cord-280549-bsnz24jx	353	23	,	,	,
cord-280549-bsnz24jx	353	24	2009	2009	CD
cord-280549-bsnz24jx	353	25	)	)	-RRB-
cord-280549-bsnz24jx	353	26	.	.	.
cord-280549-bsnz24jx	354	1	Similar	similar	JJ
cord-280549-bsnz24jx	354	2	observations	observation	NNS
cord-280549-bsnz24jx	354	3	were	be	VBD
cord-280549-bsnz24jx	354	4	made	make	VBN
cord-280549-bsnz24jx	354	5	with	with	IN
cord-280549-bsnz24jx	354	6	murine	murine	JJ
cord-280549-bsnz24jx	354	7	gammaherpesvirus	gammaherpesvirus	NNP
cord-280549-bsnz24jx	354	8	68	68	CD
cord-280549-bsnz24jx	355	1	(	(	-LRB-
cord-280549-bsnz24jx	355	2	MHV68	mhv68	NN
cord-280549-bsnz24jx	355	3	)	)	-RRB-
cord-280549-bsnz24jx	355	4	infection	infection	NN
cord-280549-bsnz24jx	355	5	(	(	-LRB-
cord-280549-bsnz24jx	355	6	Nascimento	Nascimento	NNP
cord-280549-bsnz24jx	355	7	and	and	CC
cord-280549-bsnz24jx	355	8	Parkhouse	Parkhouse	NNP
cord-280549-bsnz24jx	355	9	,	,	,
cord-280549-bsnz24jx	355	10	2007	2007	CD
cord-280549-bsnz24jx	355	11	)	)	-RRB-
cord-280549-bsnz24jx	355	12	.	.	.
cord-280549-bsnz24jx	356	1	The	the	DT
cord-280549-bsnz24jx	356	2	expression	expression	NN
cord-280549-bsnz24jx	356	3	of	of	IN
cord-280549-bsnz24jx	356	4	HSV-1	hsv-1	NN
cord-280549-bsnz24jx	356	5	immediate	immediate	JJ
cord-280549-bsnz24jx	356	6	-	-	HYPH
cord-280549-bsnz24jx	356	7	early	early	JJ
cord-280549-bsnz24jx	356	8	gene	gene	NN
cord-280549-bsnz24jx	356	9	product	product	NN
cord-280549-bsnz24jx	356	10	ICP0	ICP0	NNP
cord-280549-bsnz24jx	356	11	in	in	IN
cord-280549-bsnz24jx	356	12	HEK	HEK	NNP
cord-280549-bsnz24jx	356	13	293	293	CD
cord-280549-bsnz24jx	356	14	T	T	NNP
cord-280549-bsnz24jx	356	15	cells	cell	NNS
cord-280549-bsnz24jx	356	16	activates	activate	VBZ
cord-280549-bsnz24jx	356	17	Chk2	Chk2	NNP
cord-280549-bsnz24jx	356	18	,	,	,
cord-280549-bsnz24jx	356	19	but	but	CC
cord-280549-bsnz24jx	356	20	not	not	RB
cord-280549-bsnz24jx	356	21	Chk1	chk1	VB
cord-280549-bsnz24jx	356	22	,	,	,
cord-280549-bsnz24jx	356	23	through	through	IN
cord-280549-bsnz24jx	356	24	Thr68	Thr68	NNPS
cord-280549-bsnz24jx	356	25	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	356	26	.	.	.
cord-280549-bsnz24jx	357	1	This	this	DT
cord-280549-bsnz24jx	357	2	activation	activation	NN
cord-280549-bsnz24jx	357	3	relies	rely	VBZ
cord-280549-bsnz24jx	357	4	on	on	IN
cord-280549-bsnz24jx	357	5	ICP0-dependent	icp0-dependent	NN
cord-280549-bsnz24jx	357	6	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	357	7	of	of	IN
cord-280549-bsnz24jx	357	8	ataxia	ataxia	NN
cord-280549-bsnz24jx	357	9	telangiectasia	telangiectasia	NNP
cord-280549-bsnz24jx	357	10	mutated	mutate	VBN
cord-280549-bsnz24jx	357	11	(	(	-LRB-
cord-280549-bsnz24jx	357	12	ATM	ATM	NNP
cord-280549-bsnz24jx	357	13	)	)	-RRB-
cord-280549-bsnz24jx	357	14	,	,	,
cord-280549-bsnz24jx	357	15	an	an	DT
cord-280549-bsnz24jx	357	16	upstream	upstream	JJ
cord-280549-bsnz24jx	357	17	effector	effector	NN
cord-280549-bsnz24jx	357	18	kinase	kinase	NN
cord-280549-bsnz24jx	357	19	of	of	IN
cord-280549-bsnz24jx	357	20	Chk2	Chk2	NNP
cord-280549-bsnz24jx	357	21	,	,	,
cord-280549-bsnz24jx	357	22	as	as	IN
cord-280549-bsnz24jx	357	23	revealed	reveal	VBN
cord-280549-bsnz24jx	357	24	in	in	IN
cord-280549-bsnz24jx	357	25	ATM	atm	NN
cord-280549-bsnz24jx	357	26	-	-	HYPH
cord-280549-bsnz24jx	357	27	deficient	deficient	JJ
cord-280549-bsnz24jx	357	28	cell	cell	NN
cord-280549-bsnz24jx	357	29	lines	line	NNS
cord-280549-bsnz24jx	357	30	.	.	.
cord-280549-bsnz24jx	358	1	Activated	Activated	NNP
cord-280549-bsnz24jx	358	2	Chk2	Chk2	NNP
cord-280549-bsnz24jx	358	3	in	in	IN
cord-280549-bsnz24jx	358	4	turn	turn	NN
cord-280549-bsnz24jx	358	5	phosphorylates	phosphorylate	VBZ
cord-280549-bsnz24jx	358	6	Cdc25	Cdc25	NNP
cord-280549-bsnz24jx	358	7	on	on	IN
cord-280549-bsnz24jx	358	8	Ser216	Ser216	NNP
cord-280549-bsnz24jx	358	9	,	,	,
cord-280549-bsnz24jx	358	10	which	which	WDT
cord-280549-bsnz24jx	358	11	promotes	promote	VBZ
cord-280549-bsnz24jx	358	12	binding	binding	NN
cord-280549-bsnz24jx	358	13	of	of	IN
cord-280549-bsnz24jx	358	14	the	the	DT
cord-280549-bsnz24jx	358	15	molecule	molecule	NN
cord-280549-bsnz24jx	358	16	to	to	IN
cord-280549-bsnz24jx	358	17	14	14	CD
cord-280549-bsnz24jx	358	18	-	-	SYM
cord-280549-bsnz24jx	358	19	3	3	CD
cord-280549-bsnz24jx	358	20	-	-	SYM
cord-280549-bsnz24jx	358	21	3	3	CD
cord-280549-bsnz24jx	358	22	proteins	protein	NNS
cord-280549-bsnz24jx	358	23	,	,	,
cord-280549-bsnz24jx	358	24	resulting	result	VBG
cord-280549-bsnz24jx	358	25	in	in	IN
cord-280549-bsnz24jx	358	26	cytoplasmic	cytoplasmic	JJ
cord-280549-bsnz24jx	358	27	sequestration	sequestration	NN
cord-280549-bsnz24jx	358	28	of	of	IN
cord-280549-bsnz24jx	358	29	Cdc25C	Cdc25C	NNP
cord-280549-bsnz24jx	358	30	,	,	,
cord-280549-bsnz24jx	358	31	as	as	IN
cord-280549-bsnz24jx	358	32	discussed	discuss	VBN
cord-280549-bsnz24jx	358	33	above	above	RB
cord-280549-bsnz24jx	358	34	,	,	,
cord-280549-bsnz24jx	358	35	which	which	WDT
cord-280549-bsnz24jx	358	36	maintains	maintain	VBZ
cord-280549-bsnz24jx	358	37	high	high	JJ
cord-280549-bsnz24jx	358	38	levels	level	NNS
cord-280549-bsnz24jx	358	39	of	of	IN
cord-280549-bsnz24jx	358	40	CDK1	CDK1	NNP
cord-280549-bsnz24jx	358	41	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	358	42	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	359	1	(	(	-LRB-
cord-280549-bsnz24jx	359	2	Matsuoka	Matsuoka	NNP
cord-280549-bsnz24jx	359	3	et	et	NNP
cord-280549-bsnz24jx	359	4	al	al	NNP
cord-280549-bsnz24jx	359	5	.	.	NNP
cord-280549-bsnz24jx	359	6	,	,	,
cord-280549-bsnz24jx	359	7	1998	1998	CD
cord-280549-bsnz24jx	359	8	;	;	:
cord-280549-bsnz24jx	360	1	Graves	Graves	NNP
cord-280549-bsnz24jx	360	2	et	et	FW
cord-280549-bsnz24jx	360	3	al	al	NNP
cord-280549-bsnz24jx	360	4	.	.	NNP
cord-280549-bsnz24jx	360	5	,	,	,
cord-280549-bsnz24jx	360	6	2001	2001	CD
cord-280549-bsnz24jx	360	7	)	)	-RRB-
cord-280549-bsnz24jx	360	8	.	.	.
cord-280549-bsnz24jx	361	1	The	the	DT
cord-280549-bsnz24jx	361	2	requirement	requirement	NN
cord-280549-bsnz24jx	361	3	for	for	IN
cord-280549-bsnz24jx	361	4	the	the	DT
cord-280549-bsnz24jx	361	5	kinase	kinase	NN
cord-280549-bsnz24jx	361	6	activity	activity	NN
cord-280549-bsnz24jx	361	7	of	of	IN
cord-280549-bsnz24jx	361	8	Chk2	Chk2	NNP
cord-280549-bsnz24jx	361	9	in	in	IN
cord-280549-bsnz24jx	361	10	ICP0-induced	icp0-induce	VBN
cord-280549-bsnz24jx	361	11	inhibitory	inhibitory	NN
cord-280549-bsnz24jx	361	12	-	-	HYPH
cord-280549-bsnz24jx	361	13	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	361	14	of	of	IN
cord-280549-bsnz24jx	361	15	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	361	16	was	be	VBD
cord-280549-bsnz24jx	361	17	demonstrated	demonstrate	VBN
cord-280549-bsnz24jx	361	18	by	by	IN
cord-280549-bsnz24jx	361	19	reconstituting	reconstitute	VBG
cord-280549-bsnz24jx	361	20	Chk2-deficient	chk2-deficient	JJ
cord-280549-bsnz24jx	361	21	cells	cell	NNS
cord-280549-bsnz24jx	361	22	with	with	IN
cord-280549-bsnz24jx	361	23	kinase	kinase	NN
cord-280549-bsnz24jx	361	24	-	-	HYPH
cord-280549-bsnz24jx	361	25	defective	defective	JJ
cord-280549-bsnz24jx	361	26	mutant	mutant	JJ
cord-280549-bsnz24jx	361	27	form	form	NN
cord-280549-bsnz24jx	361	28	of	of	IN
cord-280549-bsnz24jx	361	29	Chk2	Chk2	NNP
cord-280549-bsnz24jx	361	30	.	.	.
cord-280549-bsnz24jx	362	1	Thus	thus	RB
cord-280549-bsnz24jx	362	2	,	,	,
cord-280549-bsnz24jx	362	3	through	through	IN
cord-280549-bsnz24jx	362	4	serial	serial	JJ
cord-280549-bsnz24jx	362	5	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	362	6	events	event	NNS
cord-280549-bsnz24jx	362	7	,	,	,
cord-280549-bsnz24jx	362	8	ICP0	ICP0	NNP
cord-280549-bsnz24jx	362	9	leads	lead	VBZ
cord-280549-bsnz24jx	362	10	to	to	IN
cord-280549-bsnz24jx	362	11	CDK1	CDK1	NNP
cord-280549-bsnz24jx	362	12	inactivation	inactivation	NN
cord-280549-bsnz24jx	362	13	with	with	IN
cord-280549-bsnz24jx	362	14	ensuing	ensue	VBG
cord-280549-bsnz24jx	362	15	G2	G2	NNP
cord-280549-bsnz24jx	362	16	/	/	SYM
cord-280549-bsnz24jx	362	17	M	M	NNP
cord-280549-bsnz24jx	362	18	arrest	arrest	NN
cord-280549-bsnz24jx	362	19	.	.	.
cord-280549-bsnz24jx	363	1	Similarly	similarly	RB
cord-280549-bsnz24jx	363	2	,	,	,
cord-280549-bsnz24jx	363	3	ATM	ATM	NNP
cord-280549-bsnz24jx	363	4	and	and	CC
cord-280549-bsnz24jx	363	5	Chk2	Chk2	NNP
cord-280549-bsnz24jx	363	6	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	363	7	are	be	VBP
cord-280549-bsnz24jx	363	8	required	require	VBN
cord-280549-bsnz24jx	363	9	for	for	IN
cord-280549-bsnz24jx	363	10	Rift	Rift	NNP
cord-280549-bsnz24jx	363	11	Valley	Valley	NNP
cord-280549-bsnz24jx	363	12	fever	fever	NN
cord-280549-bsnz24jx	363	13	virus	virus	NN
cord-280549-bsnz24jx	363	14	(	(	-LRB-
cord-280549-bsnz24jx	363	15	RVFV)-induced	RVFV)-induced	NNP
cord-280549-bsnz24jx	363	16	S	S	NNP
cord-280549-bsnz24jx	363	17	phase	phase	NN
cord-280549-bsnz24jx	363	18	arrest	arrest	NN
cord-280549-bsnz24jx	363	19	,	,	,
cord-280549-bsnz24jx	363	20	a	a	DT
cord-280549-bsnz24jx	363	21	phenomenon	phenomenon	NN
cord-280549-bsnz24jx	363	22	attributed	attribute	VBN
cord-280549-bsnz24jx	363	23	to	to	IN
cord-280549-bsnz24jx	363	24	the	the	DT
cord-280549-bsnz24jx	363	25	activity	activity	NN
cord-280549-bsnz24jx	363	26	of	of	IN
cord-280549-bsnz24jx	363	27	viral	viral	JJ
cord-280549-bsnz24jx	363	28	nonstructural	nonstructural	JJ
cord-280549-bsnz24jx	363	29	proteins	protein	NNS
cord-280549-bsnz24jx	363	30	(	(	-LRB-
cord-280549-bsnz24jx	363	31	Baer	Baer	NNP
cord-280549-bsnz24jx	363	32	et	et	NNP
cord-280549-bsnz24jx	363	33	al	al	NNP
cord-280549-bsnz24jx	363	34	.	.	NNP
cord-280549-bsnz24jx	363	35	,	,	,
cord-280549-bsnz24jx	363	36	2012	2012	CD
cord-280549-bsnz24jx	363	37	)	)	-RRB-
cord-280549-bsnz24jx	363	38	.	.	.
cord-280549-bsnz24jx	364	1	Infection	infection	NN
cord-280549-bsnz24jx	364	2	of	of	IN
cord-280549-bsnz24jx	364	3	a	a	DT
cord-280549-bsnz24jx	364	4	hepatocyte	hepatocyte	NN
cord-280549-bsnz24jx	364	5	cell	cell	NN
cord-280549-bsnz24jx	364	6	line	line	NN
cord-280549-bsnz24jx	364	7	with	with	IN
cord-280549-bsnz24jx	364	8	HBV	HBV	NNP
cord-280549-bsnz24jx	364	9	causes	cause	VBZ
cord-280549-bsnz24jx	364	10	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	364	11	of	of	IN
cord-280549-bsnz24jx	364	12	Chk1	Chk1	NNP
cord-280549-bsnz24jx	364	13	and	and	CC
cord-280549-bsnz24jx	364	14	p53at	p53at	NNP
cord-280549-bsnz24jx	364	15	Ser345	Ser345	NNS
cord-280549-bsnz24jx	364	16	and	and	CC
cord-280549-bsnz24jx	364	17	Ser15respectively	ser15respectively	RB
cord-280549-bsnz24jx	364	18	,	,	,
cord-280549-bsnz24jx	364	19	which	which	WDT
cord-280549-bsnz24jx	364	20	is	be	VBZ
cord-280549-bsnz24jx	364	21	accompanied	accompany	VBN
cord-280549-bsnz24jx	364	22	by	by	IN
cord-280549-bsnz24jx	364	23	a	a	DT
cord-280549-bsnz24jx	364	24	transient	transient	JJ
cord-280549-bsnz24jx	364	25	cell	cell	NN
cord-280549-bsnz24jx	364	26	cycle	cycle	NN
cord-280549-bsnz24jx	364	27	arrest	arrest	NN
cord-280549-bsnz24jx	364	28	in	in	IN
cord-280549-bsnz24jx	364	29	S	S	NNP
cord-280549-bsnz24jx	364	30	and	and	CC
cord-280549-bsnz24jx	364	31	G2	G2	NNP
cord-280549-bsnz24jx	364	32	phases	phase	NNS
cord-280549-bsnz24jx	364	33	.	.	.
cord-280549-bsnz24jx	365	1	Although	although	IN
cord-280549-bsnz24jx	365	2	more	more	JJR
cord-280549-bsnz24jx	365	3	remains	remain	NNS
cord-280549-bsnz24jx	365	4	to	to	TO
cord-280549-bsnz24jx	365	5	be	be	VB
cord-280549-bsnz24jx	365	6	done	do	VBN
cord-280549-bsnz24jx	365	7	to	to	TO
cord-280549-bsnz24jx	365	8	elucidate	elucidate	VB
cord-280549-bsnz24jx	365	9	the	the	DT
cord-280549-bsnz24jx	365	10	signaling	signal	VBG
cord-280549-bsnz24jx	365	11	pathway	pathway	NN
cord-280549-bsnz24jx	365	12	concerning	concern	VBG
cord-280549-bsnz24jx	365	13	these	these	DT
cord-280549-bsnz24jx	365	14	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	365	15	events	event	NNS
cord-280549-bsnz24jx	365	16	,	,	,
cord-280549-bsnz24jx	365	17	it	-PRON-	PRP
cord-280549-bsnz24jx	365	18	is	be	VBZ
cord-280549-bsnz24jx	365	19	known	know	VBN
cord-280549-bsnz24jx	365	20	that	that	IN
cord-280549-bsnz24jx	365	21	Chk1	Chk1	VBD
cord-280549-bsnz24jx	365	22	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	365	23	on	on	IN
cord-280549-bsnz24jx	365	24	Ser345	ser345	NN
cord-280549-bsnz24jx	365	25	is	be	VBZ
cord-280549-bsnz24jx	365	26	essential	essential	JJ
cord-280549-bsnz24jx	365	27	for	for	IN
cord-280549-bsnz24jx	365	28	the	the	DT
cord-280549-bsnz24jx	365	29	activation	activation	NN
cord-280549-bsnz24jx	365	30	of	of	IN
cord-280549-bsnz24jx	365	31	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	365	32	arrest	arrest	NN
cord-280549-bsnz24jx	365	33	in	in	IN
cord-280549-bsnz24jx	365	34	G2	G2	NNP
cord-280549-bsnz24jx	365	35	/	/	SYM
cord-280549-bsnz24jx	365	36	M	M	NNP
cord-280549-bsnz24jx	365	37	phase	phase	NN
cord-280549-bsnz24jx	366	1	(	(	-LRB-
cord-280549-bsnz24jx	366	2	Lopez	Lopez	NNP
cord-280549-bsnz24jx	366	3	-	-	HYPH
cord-280549-bsnz24jx	366	4	Girona	Girona	NNP
cord-280549-bsnz24jx	366	5	et	et	NNP
cord-280549-bsnz24jx	366	6	al	al	NNP
cord-280549-bsnz24jx	366	7	.	.	NNP
cord-280549-bsnz24jx	366	8	,	,	,
cord-280549-bsnz24jx	366	9	2001	2001	CD
cord-280549-bsnz24jx	366	10	)	)	-RRB-
cord-280549-bsnz24jx	366	11	.	.	.
cord-280549-bsnz24jx	367	1	Similarly	similarly	RB
cord-280549-bsnz24jx	367	2	,	,	,
cord-280549-bsnz24jx	367	3	Chk1	Chk1	VBD
cord-280549-bsnz24jx	367	4	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	367	5	at	at	IN
cord-280549-bsnz24jx	367	6	Ser345	ser345	NN
cord-280549-bsnz24jx	367	7	is	be	VBZ
cord-280549-bsnz24jx	367	8	required	require	VBN
cord-280549-bsnz24jx	367	9	in	in	IN
cord-280549-bsnz24jx	367	10	G2	G2	NNP
cord-280549-bsnz24jx	367	11	/	/	SYM
cord-280549-bsnz24jx	367	12	M	M	NNP
cord-280549-bsnz24jx	367	13	arrest	arrest	NN
cord-280549-bsnz24jx	367	14	induced	induce	VBN
cord-280549-bsnz24jx	367	15	by	by	IN
cord-280549-bsnz24jx	367	16	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	367	17	Vpr	Vpr	NNP
cord-280549-bsnz24jx	367	18	as	as	IN
cord-280549-bsnz24jx	367	19	re	re	NN
cord-280549-bsnz24jx	367	20	-	-	NN
cord-280549-bsnz24jx	367	21	introduction	introduction	NN
cord-280549-bsnz24jx	367	22	of	of	IN
cord-280549-bsnz24jx	367	23	a	a	DT
cord-280549-bsnz24jx	367	24	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	367	25	-	-	HYPH
cord-280549-bsnz24jx	367	26	resistant	resistant	JJ
cord-280549-bsnz24jx	367	27	Chk1	Chk1	NNP
cord-280549-bsnz24jx	367	28	mutant	mutant	NN
cord-280549-bsnz24jx	367	29	fails	fail	VBZ
cord-280549-bsnz24jx	367	30	to	to	TO
cord-280549-bsnz24jx	367	31	restore	restore	VB
cord-280549-bsnz24jx	367	32	Vpr	Vpr	NNP
cord-280549-bsnz24jx	367	33	-	-	HYPH
cord-280549-bsnz24jx	367	34	induced	induce	VBN
cord-280549-bsnz24jx	367	35	G2	G2	NNP
cord-280549-bsnz24jx	367	36	/	/	SYM
cord-280549-bsnz24jx	367	37	M	M	NNP
cord-280549-bsnz24jx	367	38	arrest	arrest	NN
cord-280549-bsnz24jx	367	39	in	in	IN
cord-280549-bsnz24jx	367	40	Chk1-depleted	chk1-deplete	VBN
cord-280549-bsnz24jx	367	41	cells	cell	NNS
cord-280549-bsnz24jx	367	42	.	.	.
cord-280549-bsnz24jx	368	1	Thus	thus	RB
cord-280549-bsnz24jx	368	2	,	,	,
cord-280549-bsnz24jx	368	3	by	by	IN
cord-280549-bsnz24jx	368	4	phosphorylating	phosphorylate	VBG
cord-280549-bsnz24jx	368	5	Chk1	Chk1	NNP
cord-280549-bsnz24jx	368	6	,	,	,
cord-280549-bsnz24jx	368	7	Vpr	Vpr	NNP
cord-280549-bsnz24jx	368	8	facilitates	facilitate	VBZ
cord-280549-bsnz24jx	368	9	proteasomemediated	proteasomemediate	VBN
cord-280549-bsnz24jx	368	10	degradation	degradation	NN
cord-280549-bsnz24jx	368	11	of	of	IN
cord-280549-bsnz24jx	368	12	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	368	13	and	and	CC
cord-280549-bsnz24jx	368	14	,	,	,
cord-280549-bsnz24jx	368	15	to	to	IN
cord-280549-bsnz24jx	368	16	a	a	DT
cord-280549-bsnz24jx	368	17	lesser	less	JJR
cord-280549-bsnz24jx	368	18	extent	extent	NN
cord-280549-bsnz24jx	368	19	,	,	,
cord-280549-bsnz24jx	368	20	Cdc25B	Cdc25B	NNP
cord-280549-bsnz24jx	368	21	,	,	,
cord-280549-bsnz24jx	368	22	contributing	contribute	VBG
cord-280549-bsnz24jx	368	23	to	to	IN
cord-280549-bsnz24jx	368	24	G2	G2	NNP
cord-280549-bsnz24jx	368	25	/	/	SYM
cord-280549-bsnz24jx	368	26	M	M	NNP
cord-280549-bsnz24jx	368	27	arrest	arrest	NN
cord-280549-bsnz24jx	369	1	(	(	-LRB-
cord-280549-bsnz24jx	369	2	Lopez	Lopez	NNP
cord-280549-bsnz24jx	369	3	-	-	HYPH
cord-280549-bsnz24jx	369	4	Girona	Girona	NNP
cord-280549-bsnz24jx	369	5	et	et	NNP
cord-280549-bsnz24jx	369	6	al	al	NNP
cord-280549-bsnz24jx	369	7	.	.	NNP
cord-280549-bsnz24jx	369	8	,	,	,
cord-280549-bsnz24jx	369	9	1999	1999	CD
cord-280549-bsnz24jx	369	10	;	;	:
cord-280549-bsnz24jx	370	1	Graves	Graves	NNP
cord-280549-bsnz24jx	370	2	et	et	FW
cord-280549-bsnz24jx	370	3	al	al	NNP
cord-280549-bsnz24jx	370	4	.	.	NNP
cord-280549-bsnz24jx	370	5	,	,	,
cord-280549-bsnz24jx	370	6	2001	2001	CD
cord-280549-bsnz24jx	371	1	;	;	:
cord-280549-bsnz24jx	371	2	Bulavin	Bulavin	NNP
cord-280549-bsnz24jx	371	3	et	et	NNP
cord-280549-bsnz24jx	371	4	al	al	NNP
cord-280549-bsnz24jx	371	5	.	.	NNP
cord-280549-bsnz24jx	371	6	,	,	,
cord-280549-bsnz24jx	371	7	2003	2003	CD
cord-280549-bsnz24jx	371	8	)	)	-RRB-
cord-280549-bsnz24jx	371	9	.	.	.
cord-280549-bsnz24jx	372	1	CDKs	cdk	NNS
cord-280549-bsnz24jx	372	2	remain	remain	VBP
cord-280549-bsnz24jx	372	3	catalytically	catalytically	RB
cord-280549-bsnz24jx	372	4	inactive	inactive	JJ
cord-280549-bsnz24jx	372	5	until	until	IN
cord-280549-bsnz24jx	372	6	cyclin	cyclin	NN
cord-280549-bsnz24jx	372	7	-	-	HYPH
cord-280549-bsnz24jx	372	8	bound	bind	VBN
cord-280549-bsnz24jx	372	9	CDKs	cdk	NNS
cord-280549-bsnz24jx	372	10	undergo	undergo	VBP
cord-280549-bsnz24jx	372	11	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	372	12	at	at	IN
cord-280549-bsnz24jx	372	13	Thr161/160/172	thr161/160/172	NN
cord-280549-bsnz24jx	372	14	by	by	IN
cord-280549-bsnz24jx	372	15	CAK	CAK	NNP
cord-280549-bsnz24jx	372	16	(	(	-LRB-
cord-280549-bsnz24jx	372	17	Gould	Gould	NNP
cord-280549-bsnz24jx	372	18	et	et	NNP
cord-280549-bsnz24jx	372	19	al	al	NNP
cord-280549-bsnz24jx	372	20	.	.	NNP
cord-280549-bsnz24jx	372	21	,	,	,
cord-280549-bsnz24jx	372	22	1991	1991	CD
cord-280549-bsnz24jx	372	23	;	;	:
cord-280549-bsnz24jx	372	24	Norbury	Norbury	NNP
cord-280549-bsnz24jx	372	25	et	et	NNP
cord-280549-bsnz24jx	372	26	al	al	NNP
cord-280549-bsnz24jx	372	27	.	.	NNP
cord-280549-bsnz24jx	372	28	,	,	,
cord-280549-bsnz24jx	372	29	1991	1991	CD
cord-280549-bsnz24jx	372	30	;	;	:
cord-280549-bsnz24jx	372	31	Desai	Desai	NNP
cord-280549-bsnz24jx	372	32	et	et	NNP
cord-280549-bsnz24jx	372	33	al	al	NNP
cord-280549-bsnz24jx	372	34	.	.	NNP
cord-280549-bsnz24jx	372	35	,	,	,
cord-280549-bsnz24jx	372	36	1992	1992	CD
cord-280549-bsnz24jx	372	37	;	;	:
cord-280549-bsnz24jx	372	38	Gu	Gu	NNP
cord-280549-bsnz24jx	372	39	et	et	NNP
cord-280549-bsnz24jx	372	40	al	al	NNP
cord-280549-bsnz24jx	372	41	.	.	NNP
cord-280549-bsnz24jx	372	42	,	,	,
cord-280549-bsnz24jx	372	43	1992	1992	CD
cord-280549-bsnz24jx	372	44	;	;	:
cord-280549-bsnz24jx	372	45	Krek	Krek	NNP
cord-280549-bsnz24jx	372	46	and	and	CC
cord-280549-bsnz24jx	372	47	Nigg	Nigg	NNP
cord-280549-bsnz24jx	372	48	,	,	,
cord-280549-bsnz24jx	372	49	1992	1992	CD
cord-280549-bsnz24jx	372	50	;	;	:
cord-280549-bsnz24jx	372	51	Solomon	Solomon	NNP
cord-280549-bsnz24jx	372	52	et	et	NNP
cord-280549-bsnz24jx	372	53	al	al	NNP
cord-280549-bsnz24jx	372	54	.	.	NNP
cord-280549-bsnz24jx	372	55	,	,	,
cord-280549-bsnz24jx	372	56	1992	1992	CD
cord-280549-bsnz24jx	372	57	)	)	-RRB-
cord-280549-bsnz24jx	372	58	.	.	.
cord-280549-bsnz24jx	373	1	The	the	DT
cord-280549-bsnz24jx	373	2	current	current	JJ
cord-280549-bsnz24jx	373	3	model	model	NN
cord-280549-bsnz24jx	373	4	of	of	IN
cord-280549-bsnz24jx	373	5	CDK	CDK	NNP
cord-280549-bsnz24jx	373	6	/	/	SYM
cord-280549-bsnz24jx	373	7	cyclin	cyclin	NN
cord-280549-bsnz24jx	373	8	activation	activation	NN
cord-280549-bsnz24jx	373	9	posits	posit	VBZ
cord-280549-bsnz24jx	373	10	two	two	CD
cord-280549-bsnz24jx	373	11	steps	step	NNS
cord-280549-bsnz24jx	373	12	:	:	:
cord-280549-bsnz24jx	373	13	(	(	-LRB-
cord-280549-bsnz24jx	373	14	i	i	NN
cord-280549-bsnz24jx	373	15	)	)	-RRB-
cord-280549-bsnz24jx	373	16	formation	formation	NN
cord-280549-bsnz24jx	373	17	of	of	IN
cord-280549-bsnz24jx	373	18	an	an	DT
cord-280549-bsnz24jx	373	19	intermediate	intermediate	JJ
cord-280549-bsnz24jx	373	20	complex	complex	NN
cord-280549-bsnz24jx	373	21	composed	compose	VBN
cord-280549-bsnz24jx	373	22	by	by	IN
cord-280549-bsnz24jx	373	23	the	the	DT
cord-280549-bsnz24jx	373	24	PSTAIRE	PSTAIRE	NNP
cord-280549-bsnz24jx	373	25	helix	helix	NN
cord-280549-bsnz24jx	373	26	of	of	IN
cord-280549-bsnz24jx	373	27	CDK2	CDK2	NNP
cord-280549-bsnz24jx	373	28	and	and	CC
cord-280549-bsnz24jx	373	29	helices	helix	NNS
cord-280549-bsnz24jx	373	30	3	3	CD
cord-280549-bsnz24jx	373	31	and	and	CC
cord-280549-bsnz24jx	373	32	5	5	CD
cord-280549-bsnz24jx	373	33	of	of	IN
cord-280549-bsnz24jx	373	34	the	the	DT
cord-280549-bsnz24jx	373	35	cyclin	cyclin	NN
cord-280549-bsnz24jx	373	36	;	;	:
cord-280549-bsnz24jx	373	37	(	(	-LRB-
cord-280549-bsnz24jx	373	38	ii	ii	NN
cord-280549-bsnz24jx	373	39	)	)	-RRB-
cord-280549-bsnz24jx	373	40	isomerization	isomerization	NN
cord-280549-bsnz24jx	373	41	of	of	IN
cord-280549-bsnz24jx	373	42	the	the	DT
cord-280549-bsnz24jx	373	43	CDK	CDK	NNP
cord-280549-bsnz24jx	373	44	/	/	SYM
cord-280549-bsnz24jx	373	45	cyclin	cyclin	NN
cord-280549-bsnz24jx	373	46	complex	complex	NN
cord-280549-bsnz24jx	373	47	to	to	TO
cord-280549-bsnz24jx	373	48	expose	expose	VB
cord-280549-bsnz24jx	373	49	the	the	DT
cord-280549-bsnz24jx	373	50	Tloop	Tloop	NNP
cord-280549-bsnz24jx	373	51	of	of	IN
cord-280549-bsnz24jx	373	52	CDK	CDK	NNP
cord-280549-bsnz24jx	373	53	,	,	,
cord-280549-bsnz24jx	373	54	which	which	WDT
cord-280549-bsnz24jx	373	55	is	be	VBZ
cord-280549-bsnz24jx	373	56	then	then	RB
cord-280549-bsnz24jx	373	57	accessible	accessible	JJ
cord-280549-bsnz24jx	373	58	to	to	IN
cord-280549-bsnz24jx	373	59	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	373	60	by	by	IN
cord-280549-bsnz24jx	373	61	CAK	CAK	NNP
cord-280549-bsnz24jx	373	62	to	to	TO
cord-280549-bsnz24jx	373	63	form	form	VB
cord-280549-bsnz24jx	373	64	the	the	DT
cord-280549-bsnz24jx	373	65	substrate	substrate	NN
cord-280549-bsnz24jx	373	66	binding	bind	VBG
cord-280549-bsnz24jx	373	67	site	site	NN
cord-280549-bsnz24jx	373	68	(	(	-LRB-
cord-280549-bsnz24jx	373	69	Morris	Morris	NNP
cord-280549-bsnz24jx	373	70	et	et	NNP
cord-280549-bsnz24jx	373	71	al	al	NNP
cord-280549-bsnz24jx	373	72	.	.	NNP
cord-280549-bsnz24jx	373	73	,	,	,
cord-280549-bsnz24jx	373	74	2002	2002	CD
cord-280549-bsnz24jx	373	75	)	)	-RRB-
cord-280549-bsnz24jx	373	76	.	.	.
cord-280549-bsnz24jx	374	1	CDK2	CDK2	NNP
cord-280549-bsnz24jx	374	2	/	/	SYM
cord-280549-bsnz24jx	374	3	CDK4	CDK4	NNP
cord-280549-bsnz24jx	374	4	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	374	5	at	at	IN
cord-280549-bsnz24jx	374	6	their	-PRON-	PRP$
cord-280549-bsnz24jx	374	7	respective	respective	JJ
cord-280549-bsnz24jx	374	8	Thr	Thr	NNP
cord-280549-bsnz24jx	374	9	sites	site	NNS
cord-280549-bsnz24jx	374	10	by	by	IN
cord-280549-bsnz24jx	374	11	CAK	CAK	NNP
cord-280549-bsnz24jx	374	12	subunits	subunit	NNS
cord-280549-bsnz24jx	374	13	,	,	,
cord-280549-bsnz24jx	374	14	for	for	IN
cord-280549-bsnz24jx	374	15	example	example	NN
cord-280549-bsnz24jx	374	16	CDK7	CDK7	NNP
cord-280549-bsnz24jx	374	17	/	/	SYM
cord-280549-bsnz24jx	374	18	cyclin	cyclin	NN
cord-280549-bsnz24jx	374	19	H	h	NN
cord-280549-bsnz24jx	374	20	,	,	,
cord-280549-bsnz24jx	374	21	is	be	VBZ
cord-280549-bsnz24jx	374	22	essential	essential	JJ
cord-280549-bsnz24jx	374	23	for	for	IN
cord-280549-bsnz24jx	374	24	both	both	CC
cord-280549-bsnz24jx	374	25	the	the	DT
cord-280549-bsnz24jx	374	26	stabilization	stabilization	NN
cord-280549-bsnz24jx	374	27	of	of	IN
cord-280549-bsnz24jx	374	28	CDK	CDK	NNP
cord-280549-bsnz24jx	374	29	/	/	SYM
cord-280549-bsnz24jx	374	30	cyclin	cyclin	NN
cord-280549-bsnz24jx	374	31	complexes	complex	NNS
cord-280549-bsnz24jx	374	32	and	and	CC
cord-280549-bsnz24jx	374	33	could	could	MD
cord-280549-bsnz24jx	374	34	increase	increase	VB
cord-280549-bsnz24jx	374	35	the	the	DT
cord-280549-bsnz24jx	374	36	flexibility	flexibility	NN
cord-280549-bsnz24jx	374	37	of	of	IN
cord-280549-bsnz24jx	374	38	the	the	DT
cord-280549-bsnz24jx	374	39	CDK2	CDK2	NNP
cord-280549-bsnz24jx	375	1	Tloop	Tloop	NNP
cord-280549-bsnz24jx	375	2	Morris	Morris	NNP
cord-280549-bsnz24jx	375	3	et	et	NNP
cord-280549-bsnz24jx	375	4	al	al	NNP
cord-280549-bsnz24jx	375	5	.	.	NNP
cord-280549-bsnz24jx	375	6	,	,	,
cord-280549-bsnz24jx	375	7	2002	2002	CD
cord-280549-bsnz24jx	375	8	)	)	-RRB-
cord-280549-bsnz24jx	375	9	.	.	.
cord-280549-bsnz24jx	376	1	Overexpression	overexpression	NN
cord-280549-bsnz24jx	376	2	of	of	IN
cord-280549-bsnz24jx	376	3	the	the	DT
cord-280549-bsnz24jx	376	4	ARV	ARV	NNP
cord-280549-bsnz24jx	376	5	p17	p17	NN
cord-280549-bsnz24jx	376	6	protein	protein	NN
cord-280549-bsnz24jx	376	7	inhibited	inhibit	VBD
cord-280549-bsnz24jx	376	8	CDK2	CDK2	NNP
cord-280549-bsnz24jx	376	9	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	376	10	at	at	IN
cord-280549-bsnz24jx	376	11	T160	T160	NNP
cord-280549-bsnz24jx	376	12	,	,	,
cord-280549-bsnz24jx	376	13	which	which	WDT
cord-280549-bsnz24jx	376	14	was	be	VBD
cord-280549-bsnz24jx	376	15	dependent	dependent	JJ
cord-280549-bsnz24jx	376	16	on	on	IN
cord-280549-bsnz24jx	376	17	CDK7	CDK7	NNP
cord-280549-bsnz24jx	376	18	/	/	SYM
cord-280549-bsnz24jx	376	19	cyclin	cyclin	NN
cord-280549-bsnz24jx	376	20	H	h	NN
cord-280549-bsnz24jx	376	21	disassociation	disassociation	NN
cord-280549-bsnz24jx	376	22	due	due	JJ
cord-280549-bsnz24jx	376	23	to	to	IN
cord-280549-bsnz24jx	376	24	increased	increase	VBN
cord-280549-bsnz24jx	376	25	p53	p53	NN
cord-280549-bsnz24jx	376	26	/	/	SYM
cord-280549-bsnz24jx	376	27	cyclin	cyclin	NN
cord-280549-bsnz24jx	376	28	H	h	NN
cord-280549-bsnz24jx	376	29	interaction	interaction	NN
cord-280549-bsnz24jx	376	30	(	(	-LRB-
cord-280549-bsnz24jx	377	1	Chiu	Chiu	NNP
cord-280549-bsnz24jx	377	2	et	et	NNP
cord-280549-bsnz24jx	377	3	al	al	NNP
cord-280549-bsnz24jx	377	4	.	.	NNP
cord-280549-bsnz24jx	377	5	,	,	,
cord-280549-bsnz24jx	377	6	2018	2018	CD
cord-280549-bsnz24jx	377	7	)	)	-RRB-
cord-280549-bsnz24jx	377	8	.	.	.
cord-280549-bsnz24jx	378	1	Thus	thus	RB
cord-280549-bsnz24jx	378	2	,	,	,
cord-280549-bsnz24jx	378	3	by	by	IN
cord-280549-bsnz24jx	378	4	diminishing	diminish	VBG
cord-280549-bsnz24jx	378	5	the	the	DT
cord-280549-bsnz24jx	378	6	CAK	CAK	NNP
cord-280549-bsnz24jx	378	7	activity	activity	NN
cord-280549-bsnz24jx	378	8	,	,	,
cord-280549-bsnz24jx	378	9	namely	namely	RB
cord-280549-bsnz24jx	378	10	CDK7	CDK7	NNP
cord-280549-bsnz24jx	378	11	/	/	SYM
cord-280549-bsnz24jx	378	12	cyclin	cyclin	NN
cord-280549-bsnz24jx	378	13	H	H	NNP
cord-280549-bsnz24jx	378	14	association	association	NN
cord-280549-bsnz24jx	378	15	,	,	,
cord-280549-bsnz24jx	378	16	p17	p17	NN
cord-280549-bsnz24jx	378	17	prevents	prevent	VBZ
cord-280549-bsnz24jx	378	18	CDK2	CDK2	NNP
cord-280549-bsnz24jx	378	19	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	378	20	and	and	CC
cord-280549-bsnz24jx	378	21	therefore	therefore	RB
cord-280549-bsnz24jx	378	22	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	378	23	its	-PRON-	PRP$
cord-280549-bsnz24jx	378	24	kinase	kinase	NN
cord-280549-bsnz24jx	378	25	activity	activity	NN
cord-280549-bsnz24jx	378	26	.	.	.
cord-280549-bsnz24jx	379	1	Although	although	IN
cord-280549-bsnz24jx	379	2	the	the	DT
cord-280549-bsnz24jx	379	3	mechanism	mechanism	NN
cord-280549-bsnz24jx	379	4	of	of	IN
cord-280549-bsnz24jx	379	5	how	how	WRB
cord-280549-bsnz24jx	379	6	p17	p17	NN
cord-280549-bsnz24jx	379	7	diminishes	diminish	VBZ
cord-280549-bsnz24jx	379	8	CAK	CAK	NNP
cord-280549-bsnz24jx	379	9	activity	activity	NN
cord-280549-bsnz24jx	379	10	in	in	IN
cord-280549-bsnz24jx	379	11	a	a	DT
cord-280549-bsnz24jx	379	12	p53-dependent	p53-dependent	NN
cord-280549-bsnz24jx	379	13	manner	manner	NN
cord-280549-bsnz24jx	379	14	remains	remain	VBZ
cord-280549-bsnz24jx	379	15	to	to	TO
cord-280549-bsnz24jx	379	16	be	be	VB
cord-280549-bsnz24jx	379	17	elucidated	elucidate	VBN
cord-280549-bsnz24jx	379	18	,	,	,
cord-280549-bsnz24jx	379	19	it	-PRON-	PRP
cord-280549-bsnz24jx	379	20	is	be	VBZ
cord-280549-bsnz24jx	379	21	another	another	DT
cord-280549-bsnz24jx	379	22	example	example	NN
cord-280549-bsnz24jx	379	23	illustrating	illustrate	VBG
cord-280549-bsnz24jx	379	24	how	how	WRB
cord-280549-bsnz24jx	379	25	viruses	virus	NNS
cord-280549-bsnz24jx	379	26	regulate	regulate	VBP
cord-280549-bsnz24jx	379	27	the	the	DT
cord-280549-bsnz24jx	379	28	cell	cell	NN
cord-280549-bsnz24jx	379	29	cycle	cycle	NN
cord-280549-bsnz24jx	379	30	machinery	machinery	NN
cord-280549-bsnz24jx	379	31	(	(	-LRB-
cord-280549-bsnz24jx	379	32	Chiu	Chiu	NNP
cord-280549-bsnz24jx	379	33	et	et	NNP
cord-280549-bsnz24jx	379	34	al	al	NNP
cord-280549-bsnz24jx	379	35	.	.	NNP
cord-280549-bsnz24jx	379	36	,	,	,
cord-280549-bsnz24jx	379	37	2018	2018	CD
cord-280549-bsnz24jx	379	38	)	)	-RRB-
cord-280549-bsnz24jx	379	39	.	.	.
cord-280549-bsnz24jx	380	1	Proteolysis	proteolysis	NN
cord-280549-bsnz24jx	380	2	of	of	IN
cord-280549-bsnz24jx	380	3	cell	cell	NN
cord-280549-bsnz24jx	380	4	cycle	cycle	NN
cord-280549-bsnz24jx	380	5	regulators	regulator	NNS
cord-280549-bsnz24jx	380	6	at	at	IN
cord-280549-bsnz24jx	380	7	defined	define	VBN
cord-280549-bsnz24jx	380	8	stages	stage	NNS
cord-280549-bsnz24jx	380	9	plays	play	VBZ
cord-280549-bsnz24jx	380	10	a	a	DT
cord-280549-bsnz24jx	380	11	crucial	crucial	JJ
cord-280549-bsnz24jx	380	12	role	role	NN
cord-280549-bsnz24jx	380	13	in	in	IN
cord-280549-bsnz24jx	380	14	cell	cell	NN
cord-280549-bsnz24jx	380	15	cycle	cycle	NN
cord-280549-bsnz24jx	380	16	progression	progression	NN
cord-280549-bsnz24jx	380	17	.	.	.
cord-280549-bsnz24jx	381	1	While	while	IN
cord-280549-bsnz24jx	381	2	purified	purify	VBN
cord-280549-bsnz24jx	381	3	recombinant	recombinant	JJ
cord-280549-bsnz24jx	381	4	IE2	ie2	NN
cord-280549-bsnz24jx	381	5	-	-	HYPH
cord-280549-bsnz24jx	381	6	86	86	CD
cord-280549-bsnz24jx	381	7	of	of	IN
cord-280549-bsnz24jx	381	8	HCMV	HCMV	NNP
cord-280549-bsnz24jx	381	9	is	be	VBZ
cord-280549-bsnz24jx	381	10	able	able	JJ
cord-280549-bsnz24jx	381	11	to	to	TO
cord-280549-bsnz24jx	381	12	block	block	VB
cord-280549-bsnz24jx	381	13	the	the	DT
cord-280549-bsnz24jx	381	14	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	381	15	effect	effect	NN
cord-280549-bsnz24jx	381	16	of	of	IN
cord-280549-bsnz24jx	381	17	the	the	DT
cord-280549-bsnz24jx	381	18	cyclin	cyclin	NN
cord-280549-bsnz24jx	381	19	-	-	HYPH
cord-280549-bsnz24jx	381	20	dependent	dependent	JJ
cord-280549-bsnz24jx	381	21	kinase	kinase	NN
cord-280549-bsnz24jx	381	22	inhibitor	inhibitor	NN
cord-280549-bsnz24jx	381	23	p21	p21	NN
cord-280549-bsnz24jx	381	24	WAF1	WAF1	NNP
cord-280549-bsnz24jx	381	25	/	/	SYM
cord-280549-bsnz24jx	381	26	CIP1	CIP1	NNP
cord-280549-bsnz24jx	381	27	through	through	IN
cord-280549-bsnz24jx	381	28	physical	physical	JJ
cord-280549-bsnz24jx	381	29	interaction	interaction	NN
cord-280549-bsnz24jx	381	30	as	as	IN
cord-280549-bsnz24jx	381	31	previously	previously	RB
cord-280549-bsnz24jx	381	32	mentioned	mention	VBN
cord-280549-bsnz24jx	381	33	,	,	,
cord-280549-bsnz24jx	381	34	HCMV	HCMV	NNP
cord-280549-bsnz24jx	381	35	infection	infection	NN
cord-280549-bsnz24jx	381	36	can	can	MD
cord-280549-bsnz24jx	381	37	also	also	RB
cord-280549-bsnz24jx	381	38	target	target	VB
cord-280549-bsnz24jx	381	39	p21	p21	NN
cord-280549-bsnz24jx	381	40	WAF1	WAF1	NNP
cord-280549-bsnz24jx	381	41	/	/	SYM
cord-280549-bsnz24jx	381	42	CIP1	CIP1	NNP
cord-280549-bsnz24jx	381	43	todegradation	todegradation	NN
cord-280549-bsnz24jx	381	44	.	.	.
cord-280549-bsnz24jx	382	1	Thus	thus	RB
cord-280549-bsnz24jx	382	2	,	,	,
cord-280549-bsnz24jx	382	3	a	a	DT
cord-280549-bsnz24jx	382	4	disparity	disparity	NN
cord-280549-bsnz24jx	382	5	between	between	IN
cord-280549-bsnz24jx	382	6	p21	p21	NN
cord-280549-bsnz24jx	382	7	WAF1	WAF1	NNP
cord-280549-bsnz24jx	382	8	/	/	SYM
cord-280549-bsnz24jx	382	9	CIP1	CIP1	NNP
cord-280549-bsnz24jx	382	10	RNA	RNA	NNP
cord-280549-bsnz24jx	382	11	and	and	CC
cord-280549-bsnz24jx	382	12	protein	protein	NN
cord-280549-bsnz24jx	382	13	levels	level	NNS
cord-280549-bsnz24jx	382	14	was	be	VBD
cord-280549-bsnz24jx	382	15	observed	observe	VBN
cord-280549-bsnz24jx	382	16	after	after	IN
cord-280549-bsnz24jx	382	17	HCMV	HCMV	NNP
cord-280549-bsnz24jx	382	18	infection	infection	NN
cord-280549-bsnz24jx	382	19	,	,	,
cord-280549-bsnz24jx	382	20	implying	imply	VBG
cord-280549-bsnz24jx	382	21	possible	possible	JJ
cord-280549-bsnz24jx	382	22	degradation	degradation	NN
cord-280549-bsnz24jx	382	23	of	of	IN
cord-280549-bsnz24jx	382	24	p21	p21	NN
cord-280549-bsnz24jx	382	25	WAF1	WAF1	NNP
cord-280549-bsnz24jx	382	26	/	/	SYM
cord-280549-bsnz24jx	382	27	CIP1	CIP1	NNP
cord-280549-bsnz24jx	382	28	in	in	IN
cord-280549-bsnz24jx	382	29	virus	virus	NN
cord-280549-bsnz24jx	382	30	-	-	HYPH
cord-280549-bsnz24jx	382	31	infected	infect	VBN
cord-280549-bsnz24jx	382	32	cells	cell	NNS
cord-280549-bsnz24jx	382	33	.	.	.
cord-280549-bsnz24jx	383	1	Infection	infection	NN
cord-280549-bsnz24jx	383	2	could	could	MD
cord-280549-bsnz24jx	383	3	induce	induce	VB
cord-280549-bsnz24jx	383	4	sustained	sustained	JJ
cord-280549-bsnz24jx	383	5	increase	increase	NN
cord-280549-bsnz24jx	383	6	in	in	IN
cord-280549-bsnz24jx	383	7	calpain	calpain	NN
cord-280549-bsnz24jx	383	8	activity	activity	NN
cord-280549-bsnz24jx	383	9	and	and	CC
cord-280549-bsnz24jx	383	10	the	the	DT
cord-280549-bsnz24jx	383	11	use	use	NN
cord-280549-bsnz24jx	383	12	of	of	IN
cord-280549-bsnz24jx	383	13	specific	specific	JJ
cord-280549-bsnz24jx	383	14	inhibitors	inhibitor	NNS
cord-280549-bsnz24jx	383	15	demonstrated	demonstrate	VBD
cord-280549-bsnz24jx	383	16	that	that	IN
cord-280549-bsnz24jx	383	17	calpain	calpain	NN
cord-280549-bsnz24jx	383	18	,	,	,
cord-280549-bsnz24jx	383	19	and	and	CC
cord-280549-bsnz24jx	383	20	not	not	RB
cord-280549-bsnz24jx	383	21	proteasome	proteasome	VBN
cord-280549-bsnz24jx	383	22	activity	activity	NN
cord-280549-bsnz24jx	383	23	is	be	VBZ
cord-280549-bsnz24jx	383	24	required	require	VBN
cord-280549-bsnz24jx	383	25	for	for	IN
cord-280549-bsnz24jx	383	26	HCMV	HCMV	NNP
cord-280549-bsnz24jx	383	27	-	-	HYPH
cord-280549-bsnz24jx	383	28	mediated	mediate	VBN
cord-280549-bsnz24jx	383	29	p21	p21	NN
cord-280549-bsnz24jx	383	30	WAF1	WAF1	NNP
cord-280549-bsnz24jx	383	31	/	/	SYM
cord-280549-bsnz24jx	383	32	CIP1	CIP1	NNP
cord-280549-bsnz24jx	383	33	reduction	reduction	NN
cord-280549-bsnz24jx	383	34	,	,	,
cord-280549-bsnz24jx	383	35	although	although	IN
cord-280549-bsnz24jx	383	36	the	the	DT
cord-280549-bsnz24jx	383	37	molecular	molecular	JJ
cord-280549-bsnz24jx	383	38	mechanism	mechanism	NN
cord-280549-bsnz24jx	383	39	by	by	IN
cord-280549-bsnz24jx	383	40	which	which	WDT
cord-280549-bsnz24jx	383	41	p21	p21	NN
cord-280549-bsnz24jx	383	42	WAF1	WAF1	NNP
cord-280549-bsnz24jx	383	43	/	/	SYM
cord-280549-bsnz24jx	383	44	CIP1	CIP1	NNP
cord-280549-bsnz24jx	383	45	is	be	VBZ
cord-280549-bsnz24jx	383	46	targeted	target	VBN
cord-280549-bsnz24jx	383	47	by	by	IN
cord-280549-bsnz24jx	383	48	calpain	calpain	NNP
cord-280549-bsnz24jx	383	49	is	be	VBZ
cord-280549-bsnz24jx	383	50	not	not	RB
cord-280549-bsnz24jx	383	51	clear	clear	JJ
cord-280549-bsnz24jx	383	52	.	.	.
cord-280549-bsnz24jx	384	1	The	the	DT
cord-280549-bsnz24jx	384	2	interaction	interaction	NN
cord-280549-bsnz24jx	384	3	between	between	IN
cord-280549-bsnz24jx	384	4	cyclin	cyclin	NN
cord-280549-bsnz24jx	384	5	D3	D3	NNP
cord-280549-bsnz24jx	384	6	and	and	CC
cord-280549-bsnz24jx	384	7	M2	M2	NNP
cord-280549-bsnz24jx	384	8	during	during	IN
cord-280549-bsnz24jx	384	9	Influenza	Influenza	NNP
cord-280549-bsnz24jx	384	10	A	a	DT
cord-280549-bsnz24jx	384	11	infection	infection	NN
cord-280549-bsnz24jx	384	12	provides	provide	VBZ
cord-280549-bsnz24jx	384	13	another	another	DT
cord-280549-bsnz24jx	384	14	example	example	NN
cord-280549-bsnz24jx	384	15	of	of	IN
cord-280549-bsnz24jx	384	16	the	the	DT
cord-280549-bsnz24jx	384	17	involvement	involvement	NN
cord-280549-bsnz24jx	384	18	of	of	IN
cord-280549-bsnz24jx	384	19	the	the	DT
cord-280549-bsnz24jx	384	20	proteasomal	proteasomal	JJ
cord-280549-bsnz24jx	384	21	degradation	degradation	NN
cord-280549-bsnz24jx	384	22	pathway	pathway	NN
cord-280549-bsnz24jx	384	23	.	.	.
cord-280549-bsnz24jx	385	1	Although	although	IN
cord-280549-bsnz24jx	385	2	the	the	DT
cord-280549-bsnz24jx	385	3	interaction	interaction	NN
cord-280549-bsnz24jx	385	4	was	be	VBD
cord-280549-bsnz24jx	385	5	found	find	VBN
cord-280549-bsnz24jx	385	6	to	to	TO
cord-280549-bsnz24jx	385	7	inhibit	inhibit	VB
cord-280549-bsnz24jx	385	8	virus	virus	NN
cord-280549-bsnz24jx	385	9	production	production	NN
cord-280549-bsnz24jx	385	10	,	,	,
cord-280549-bsnz24jx	385	11	this	this	DT
cord-280549-bsnz24jx	385	12	mode	mode	NN
cord-280549-bsnz24jx	385	13	of	of	IN
cord-280549-bsnz24jx	385	14	restriction	restriction	NN
cord-280549-bsnz24jx	385	15	eventually	eventually	RB
cord-280549-bsnz24jx	385	16	surrenders	surrender	VBZ
cord-280549-bsnz24jx	385	17	to	to	IN
cord-280549-bsnz24jx	385	18	viral	viral	JJ
cord-280549-bsnz24jx	385	19	infection	infection	NN
cord-280549-bsnz24jx	385	20	as	as	IN
cord-280549-bsnz24jx	385	21	cyclin	cyclin	NN
cord-280549-bsnz24jx	385	22	D3	D3	NNP
cord-280549-bsnz24jx	385	23	becomes	become	VBZ
cord-280549-bsnz24jx	385	24	trapped	trap	VBN
cord-280549-bsnz24jx	385	25	in	in	IN
cord-280549-bsnz24jx	385	26	the	the	DT
cord-280549-bsnz24jx	385	27	cytoplasm	cytoplasm	NN
cord-280549-bsnz24jx	385	28	by	by	IN
cord-280549-bsnz24jx	385	29	M2	M2	NNP
cord-280549-bsnz24jx	385	30	and	and	CC
cord-280549-bsnz24jx	385	31	eventually	eventually	RB
cord-280549-bsnz24jx	385	32	undergoes	undergo	VBZ
cord-280549-bsnz24jx	385	33	proteasomal	proteasomal	JJ
cord-280549-bsnz24jx	385	34	degradation	degradation	NN
cord-280549-bsnz24jx	385	35	upon	upon	IN
cord-280549-bsnz24jx	385	36	prolonged	prolong	VBN
cord-280549-bsnz24jx	385	37	infection	infection	NN
cord-280549-bsnz24jx	385	38	(	(	-LRB-
cord-280549-bsnz24jx	385	39	Fan	fan	NN
cord-280549-bsnz24jx	385	40	et	et	NNP
cord-280549-bsnz24jx	385	41	al	al	NNP
cord-280549-bsnz24jx	385	42	.	.	NNP
cord-280549-bsnz24jx	385	43	,	,	,
cord-280549-bsnz24jx	385	44	2017	2017	CD
cord-280549-bsnz24jx	385	45	)	)	-RRB-
cord-280549-bsnz24jx	385	46	.	.	.
cord-280549-bsnz24jx	386	1	Indeed	indeed	RB
cord-280549-bsnz24jx	386	2	,	,	,
cord-280549-bsnz24jx	386	3	mislocalization	mislocalization	NN
cord-280549-bsnz24jx	386	4	and	and	CC
cord-280549-bsnz24jx	386	5	subsequent	subsequent	JJ
cord-280549-bsnz24jx	386	6	downregulation	downregulation	NN
cord-280549-bsnz24jx	386	7	of	of	IN
cord-280549-bsnz24jx	386	8	restriction	restriction	NN
cord-280549-bsnz24jx	386	9	factors	factor	NNS
cord-280549-bsnz24jx	386	10	is	be	VBZ
cord-280549-bsnz24jx	386	11	one	one	CD
cord-280549-bsnz24jx	386	12	of	of	IN
cord-280549-bsnz24jx	386	13	the	the	DT
cord-280549-bsnz24jx	386	14	recurring	recur	VBG
cord-280549-bsnz24jx	386	15	mechanisms	mechanism	NNS
cord-280549-bsnz24jx	386	16	viruses	virus	NNS
cord-280549-bsnz24jx	386	17	have	have	VBP
cord-280549-bsnz24jx	386	18	adopted	adopt	VBN
cord-280549-bsnz24jx	386	19	to	to	TO
cord-280549-bsnz24jx	386	20	overcome	overcome	VB
cord-280549-bsnz24jx	386	21	host	host	NN
cord-280549-bsnz24jx	386	22	defenses	defense	NNS
cord-280549-bsnz24jx	387	1	(	(	-LRB-
cord-280549-bsnz24jx	387	2	Ma	Ma	NNP
cord-280549-bsnz24jx	387	3	et	et	NNP
cord-280549-bsnz24jx	387	4	al	al	NNP
cord-280549-bsnz24jx	387	5	.	.	NNP
cord-280549-bsnz24jx	387	6	,	,	,
cord-280549-bsnz24jx	387	7	2012	2012	CD
cord-280549-bsnz24jx	387	8	)	)	-RRB-
cord-280549-bsnz24jx	387	9	.	.	.
cord-280549-bsnz24jx	388	1	In	in	IN
cord-280549-bsnz24jx	388	2	the	the	DT
cord-280549-bsnz24jx	388	3	case	case	NN
cord-280549-bsnz24jx	388	4	of	of	IN
cord-280549-bsnz24jx	388	5	IAV	IAV	NNP
cord-280549-bsnz24jx	388	6	,	,	,
cord-280549-bsnz24jx	388	7	two	two	CD
cord-280549-bsnz24jx	388	8	possible	possible	JJ
cord-280549-bsnz24jx	388	9	mechanisms	mechanism	NNS
cord-280549-bsnz24jx	388	10	account	account	VBP
cord-280549-bsnz24jx	388	11	for	for	IN
cord-280549-bsnz24jx	388	12	the	the	DT
cord-280549-bsnz24jx	388	13	relocalization	relocalization	NN
cord-280549-bsnz24jx	388	14	of	of	IN
cord-280549-bsnz24jx	388	15	cyclin	cyclin	NNP
cord-280549-bsnz24jx	388	16	D3	D3	NNP
cord-280549-bsnz24jx	388	17	to	to	IN
cord-280549-bsnz24jx	388	18	the	the	DT
cord-280549-bsnz24jx	388	19	cytoplasm	cytoplasm	NN
cord-280549-bsnz24jx	388	20	:	:	:
cord-280549-bsnz24jx	388	21	(	(	-LRB-
cord-280549-bsnz24jx	388	22	i	i	NN
cord-280549-bsnz24jx	388	23	)	)	-RRB-
cord-280549-bsnz24jx	388	24	M2	M2	NNP
cord-280549-bsnz24jx	388	25	interacts	interact	VBZ
cord-280549-bsnz24jx	388	26	with	with	IN
cord-280549-bsnz24jx	388	27	newly	newly	RB
cord-280549-bsnz24jx	388	28	synthesized	synthesize	VBN
cord-280549-bsnz24jx	388	29	cyclin	cyclin	NN
cord-280549-bsnz24jx	388	30	D3	D3	NNP
cord-280549-bsnz24jx	388	31	and	and	CC
cord-280549-bsnz24jx	388	32	prevents	prevent	VBZ
cord-280549-bsnz24jx	388	33	it	-PRON-	PRP
cord-280549-bsnz24jx	388	34	from	from	IN
cord-280549-bsnz24jx	388	35	translocating	translocate	VBG
cord-280549-bsnz24jx	388	36	into	into	IN
cord-280549-bsnz24jx	388	37	the	the	DT
cord-280549-bsnz24jx	388	38	nucleus	nucleus	NN
cord-280549-bsnz24jx	388	39	,	,	,
cord-280549-bsnz24jx	388	40	or	or	CC
cord-280549-bsnz24jx	388	41	(	(	-LRB-
cord-280549-bsnz24jx	388	42	ii	ii	NN
cord-280549-bsnz24jx	388	43	)	)	-RRB-
cord-280549-bsnz24jx	389	1	cyclin	cyclin	NNP
cord-280549-bsnz24jx	389	2	D3	D3	NNP
cord-280549-bsnz24jx	389	3	is	be	VBZ
cord-280549-bsnz24jx	389	4	retained	retain	VBN
cord-280549-bsnz24jx	389	5	by	by	IN
cord-280549-bsnz24jx	389	6	M2	M2	NNP
cord-280549-bsnz24jx	389	7	in	in	IN
cord-280549-bsnz24jx	389	8	the	the	DT
cord-280549-bsnz24jx	389	9	cytoplasm	cytoplasm	NN
cord-280549-bsnz24jx	389	10	after	after	IN
cord-280549-bsnz24jx	389	11	its	-PRON-	PRP$
cord-280549-bsnz24jx	389	12	nuclear	nuclear	JJ
cord-280549-bsnz24jx	389	13	export	export	NN
cord-280549-bsnz24jx	389	14	.	.	.
cord-280549-bsnz24jx	390	1	It	-PRON-	PRP
cord-280549-bsnz24jx	390	2	will	will	MD
cord-280549-bsnz24jx	390	3	be	be	VB
cord-280549-bsnz24jx	390	4	interesting	interesting	JJ
cord-280549-bsnz24jx	390	5	to	to	TO
cord-280549-bsnz24jx	390	6	explore	explore	VB
cord-280549-bsnz24jx	390	7	these	these	DT
cord-280549-bsnz24jx	390	8	mechanisms	mechanism	NNS
cord-280549-bsnz24jx	390	9	in	in	IN
cord-280549-bsnz24jx	390	10	greater	great	JJR
cord-280549-bsnz24jx	390	11	detail	detail	NN
cord-280549-bsnz24jx	390	12	in	in	IN
cord-280549-bsnz24jx	390	13	future	future	JJ
cord-280549-bsnz24jx	390	14	studies	study	NNS
cord-280549-bsnz24jx	390	15	.	.	.
cord-280549-bsnz24jx	391	1	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	391	2	viral	viral	JJ
cord-280549-bsnz24jx	391	3	infectivity	infectivity	NN
cord-280549-bsnz24jx	391	4	factor	factor	NN
cord-280549-bsnz24jx	391	5	(	(	-LRB-
cord-280549-bsnz24jx	391	6	Vif	vif	NN
cord-280549-bsnz24jx	391	7	)	)	-RRB-
cord-280549-bsnz24jx	391	8	binds	bind	VBZ
cord-280549-bsnz24jx	391	9	to	to	IN
cord-280549-bsnz24jx	391	10	the	the	DT
cord-280549-bsnz24jx	391	11	central	central	JJ
cord-280549-bsnz24jx	391	12	domain	domain	NN
cord-280549-bsnz24jx	391	13	of	of	IN
cord-280549-bsnz24jx	391	14	mouse	mouse	NN
cord-280549-bsnz24jx	391	15	double	double	JJ
cord-280549-bsnz24jx	391	16	-	-	HYPH
cord-280549-bsnz24jx	391	17	minute	minute	NN
cord-280549-bsnz24jx	391	18	2	2	CD
cord-280549-bsnz24jx	391	19	protein	protein	NN
cord-280549-bsnz24jx	391	20	(	(	-LRB-
cord-280549-bsnz24jx	391	21	MDM2	MDM2	NNP
cord-280549-bsnz24jx	391	22	)	)	-RRB-
cord-280549-bsnz24jx	391	23	,	,	,
cord-280549-bsnz24jx	391	24	the	the	DT
cord-280549-bsnz24jx	391	25	primary	primary	JJ
cord-280549-bsnz24jx	391	26	E3	e3	NN
cord-280549-bsnz24jx	391	27	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	391	28	ligase	ligase	NN
cord-280549-bsnz24jx	391	29	for	for	IN
cord-280549-bsnz24jx	391	30	p53	p53	NN
cord-280549-bsnz24jx	392	1	(	(	-LRB-
cord-280549-bsnz24jx	392	2	Momand	Momand	NNP
cord-280549-bsnz24jx	392	3	et	et	NNP
cord-280549-bsnz24jx	392	4	al	al	NNP
cord-280549-bsnz24jx	392	5	.	.	NNP
cord-280549-bsnz24jx	392	6	,	,	,
cord-280549-bsnz24jx	392	7	2000	2000	CD
cord-280549-bsnz24jx	392	8	;	;	:
cord-280549-bsnz24jx	392	9	Izumi	Izumi	NNP
cord-280549-bsnz24jx	392	10	et	et	NNP
cord-280549-bsnz24jx	392	11	al	al	NNP
cord-280549-bsnz24jx	392	12	.	.	NNP
cord-280549-bsnz24jx	392	13	,	,	,
cord-280549-bsnz24jx	392	14	2009	2009	CD
cord-280549-bsnz24jx	392	15	)	)	-RRB-
cord-280549-bsnz24jx	392	16	.	.	.
cord-280549-bsnz24jx	393	1	Izumi	Izumi	NNP
cord-280549-bsnz24jx	393	2	et	et	NNP
cord-280549-bsnz24jx	393	3	al	al	NNP
cord-280549-bsnz24jx	393	4	.	.	NNP
cord-280549-bsnz24jx	393	5	showed	show	VBD
cord-280549-bsnz24jx	393	6	that	that	IN
cord-280549-bsnz24jx	393	7	expression	expression	NN
cord-280549-bsnz24jx	393	8	of	of	IN
cord-280549-bsnz24jx	393	9	Vif	Vif	NNP
cord-280549-bsnz24jx	393	10	could	could	MD
cord-280549-bsnz24jx	393	11	block	block	VB
cord-280549-bsnz24jx	393	12	MDM2-mediated	mdm2-mediated	JJ
cord-280549-bsnz24jx	393	13	proteasomal	proteasomal	JJ
cord-280549-bsnz24jx	393	14	degradation	degradation	NN
cord-280549-bsnz24jx	393	15	of	of	IN
cord-280549-bsnz24jx	393	16	p53	p53	NN
cord-280549-bsnz24jx	393	17	,	,	,
cord-280549-bsnz24jx	393	18	leading	lead	VBG
cord-280549-bsnz24jx	393	19	to	to	IN
cord-280549-bsnz24jx	393	20	cell	cell	NN
cord-280549-bsnz24jx	393	21	cycle	cycle	NN
cord-280549-bsnz24jx	393	22	arrest	arrest	NN
cord-280549-bsnz24jx	393	23	in	in	IN
cord-280549-bsnz24jx	393	24	G2	G2	NNP
cord-280549-bsnz24jx	393	25	(	(	-LRB-
cord-280549-bsnz24jx	393	26	Izumi	Izumi	NNP
cord-280549-bsnz24jx	393	27	et	et	FW
cord-280549-bsnz24jx	393	28	al	al	NNP
cord-280549-bsnz24jx	393	29	.	.	NNP
cord-280549-bsnz24jx	393	30	,	,	,
cord-280549-bsnz24jx	393	31	2010	2010	CD
cord-280549-bsnz24jx	393	32	)	)	-RRB-
cord-280549-bsnz24jx	393	33	.	.	.
cord-280549-bsnz24jx	394	1	More	more	RBR
cord-280549-bsnz24jx	394	2	interestingly	interestingly	RB
cord-280549-bsnz24jx	394	3	,	,	,
cord-280549-bsnz24jx	394	4	the	the	DT
cord-280549-bsnz24jx	394	5	same	same	JJ
cord-280549-bsnz24jx	394	6	study	study	NN
cord-280549-bsnz24jx	394	7	reported	report	VBD
cord-280549-bsnz24jx	394	8	that	that	IN
cord-280549-bsnz24jx	394	9	Vif	Vif	NNP
cord-280549-bsnz24jx	394	10	could	could	MD
cord-280549-bsnz24jx	394	11	directly	directly	RB
cord-280549-bsnz24jx	394	12	interact	interact	VB
cord-280549-bsnz24jx	394	13	with	with	IN
cord-280549-bsnz24jx	394	14	p53	p53	NN
cord-280549-bsnz24jx	394	15	,	,	,
cord-280549-bsnz24jx	394	16	independent	independent	JJ
cord-280549-bsnz24jx	394	17	of	of	IN
cord-280549-bsnz24jx	394	18	its	-PRON-	PRP$
cord-280549-bsnz24jx	394	19	association	association	NN
cord-280549-bsnz24jx	394	20	with	with	IN
cord-280549-bsnz24jx	394	21	MDM2	MDM2	NNP
cord-280549-bsnz24jx	394	22	,	,	,
cord-280549-bsnz24jx	394	23	leading	lead	VBG
cord-280549-bsnz24jx	394	24	to	to	IN
cord-280549-bsnz24jx	394	25	a	a	DT
cord-280549-bsnz24jx	394	26	partial	partial	JJ
cord-280549-bsnz24jx	394	27	blockage	blockage	NN
cord-280549-bsnz24jx	394	28	of	of	IN
cord-280549-bsnz24jx	394	29	p53-MDM2	p53-MDM2	NNPS
cord-280549-bsnz24jx	394	30	binding	bind	VBG
cord-280549-bsnz24jx	394	31	and	and	CC
cord-280549-bsnz24jx	394	32	,	,	,
cord-280549-bsnz24jx	394	33	hence	hence	RB
cord-280549-bsnz24jx	394	34	,	,	,
cord-280549-bsnz24jx	394	35	impairment	impairment	NN
cord-280549-bsnz24jx	394	36	of	of	IN
cord-280549-bsnz24jx	394	37	MDM2-mediated	mdm2-mediated	JJ
cord-280549-bsnz24jx	394	38	p53	p53	NN
cord-280549-bsnz24jx	394	39	degradation	degradation	NN
cord-280549-bsnz24jx	394	40	.	.	.
cord-280549-bsnz24jx	395	1	This	this	DT
cord-280549-bsnz24jx	395	2	strategy	strategy	NN
cord-280549-bsnz24jx	395	3	appears	appear	VBZ
cord-280549-bsnz24jx	395	4	to	to	TO
cord-280549-bsnz24jx	395	5	be	be	VB
cord-280549-bsnz24jx	395	6	very	very	RB
cord-280549-bsnz24jx	395	7	effective	effective	JJ
cord-280549-bsnz24jx	395	8	and	and	CC
cord-280549-bsnz24jx	395	9	economical	economical	JJ
cord-280549-bsnz24jx	395	10	,	,	,
cord-280549-bsnz24jx	395	11	as	as	IN
cord-280549-bsnz24jx	395	12	it	-PRON-	PRP
cord-280549-bsnz24jx	395	13	has	have	VBZ
cord-280549-bsnz24jx	395	14	been	be	VBN
cord-280549-bsnz24jx	395	15	adopted	adopt	VBN
cord-280549-bsnz24jx	395	16	by	by	IN
cord-280549-bsnz24jx	395	17	other	other	JJ
cord-280549-bsnz24jx	395	18	viruses	virus	NNS
cord-280549-bsnz24jx	395	19	.	.	.
cord-280549-bsnz24jx	396	1	For	for	IN
cord-280549-bsnz24jx	396	2	example	example	NN
cord-280549-bsnz24jx	396	3	,	,	,
cord-280549-bsnz24jx	396	4	the	the	DT
cord-280549-bsnz24jx	396	5	IAV	IAV	NNP
cord-280549-bsnz24jx	396	6	nucleoprotein	nucleoprotein	NNP
cord-280549-bsnz24jx	396	7	(	(	-LRB-
cord-280549-bsnz24jx	396	8	NP	NP	NNP
cord-280549-bsnz24jx	396	9	)	)	-RRB-
cord-280549-bsnz24jx	396	10	binds	bind	VBZ
cord-280549-bsnz24jx	396	11	to	to	IN
cord-280549-bsnz24jx	396	12	p53	p53	NN
cord-280549-bsnz24jx	396	13	with	with	IN
cord-280549-bsnz24jx	396	14	ensuing	ensue	VBG
cord-280549-bsnz24jx	396	15	protein	protein	NN
cord-280549-bsnz24jx	396	16	stabilization	stabilization	NN
cord-280549-bsnz24jx	396	17	as	as	IN
cord-280549-bsnz24jx	396	18	a	a	DT
cord-280549-bsnz24jx	396	19	result	result	NN
cord-280549-bsnz24jx	396	20	of	of	IN
cord-280549-bsnz24jx	396	21	compromised	compromised	JJ
cord-280549-bsnz24jx	396	22	MDM2-mediated	mdm2-mediated	JJ
cord-280549-bsnz24jx	396	23	p53	p53	NN
cord-280549-bsnz24jx	396	24	degradation	degradation	NN
cord-280549-bsnz24jx	396	25	(	(	-LRB-
cord-280549-bsnz24jx	396	26	Wang	Wang	NNP
cord-280549-bsnz24jx	396	27	et	et	NNP
cord-280549-bsnz24jx	396	28	al	al	NNP
cord-280549-bsnz24jx	396	29	.	.	NNP
cord-280549-bsnz24jx	396	30	,	,	,
cord-280549-bsnz24jx	396	31	2012	2012	CD
cord-280549-bsnz24jx	396	32	)	)	-RRB-
cord-280549-bsnz24jx	396	33	.	.	.
cord-280549-bsnz24jx	397	1	ARV	ARV	NNP
cord-280549-bsnz24jx	397	2	infection	infection	NN
cord-280549-bsnz24jx	397	3	promotes	promote	VBZ
cord-280549-bsnz24jx	397	4	p53	p53	NN
cord-280549-bsnz24jx	397	5	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	397	6	at	at	IN
cord-280549-bsnz24jx	397	7	multiple	multiple	JJ
cord-280549-bsnz24jx	397	8	sites	site	NNS
cord-280549-bsnz24jx	397	9	,	,	,
cord-280549-bsnz24jx	397	10	an	an	DT
cord-280549-bsnz24jx	397	11	event	event	NN
cord-280549-bsnz24jx	397	12	which	which	WDT
cord-280549-bsnz24jx	397	13	alleviates	alleviate	VBZ
cord-280549-bsnz24jx	397	14	p53	p53	NN
cord-280549-bsnz24jx	397	15	inhibition	inhibition	NN
cord-280549-bsnz24jx	397	16	by	by	IN
cord-280549-bsnz24jx	397	17	MDM2	MDM2	NNP
cord-280549-bsnz24jx	397	18	(	(	-LRB-
cord-280549-bsnz24jx	397	19	Shieh	Shieh	NNP
cord-280549-bsnz24jx	397	20	et	et	NNP
cord-280549-bsnz24jx	397	21	al	al	NNP
cord-280549-bsnz24jx	397	22	.	.	NNP
cord-280549-bsnz24jx	397	23	,	,	,
cord-280549-bsnz24jx	397	24	1997	1997	CD
cord-280549-bsnz24jx	397	25	)	)	-RRB-
cord-280549-bsnz24jx	397	26	,	,	,
cord-280549-bsnz24jx	397	27	and	and	CC
cord-280549-bsnz24jx	397	28	activates	activate	VBZ
cord-280549-bsnz24jx	397	29	the	the	DT
cord-280549-bsnz24jx	397	30	transcriptional	transcriptional	JJ
cord-280549-bsnz24jx	397	31	function	function	NN
cord-280549-bsnz24jx	397	32	of	of	IN
cord-280549-bsnz24jx	397	33	p53	p53	NN
cord-280549-bsnz24jx	397	34	(	(	-LRB-
cord-280549-bsnz24jx	397	35	Lin	Lin	NNP
cord-280549-bsnz24jx	397	36	et	et	NNP
cord-280549-bsnz24jx	397	37	al	al	NNP
cord-280549-bsnz24jx	397	38	.	.	NNP
cord-280549-bsnz24jx	397	39	,	,	,
cord-280549-bsnz24jx	397	40	2009	2009	CD
cord-280549-bsnz24jx	397	41	)	)	-RRB-
cord-280549-bsnz24jx	397	42	.	.	.
cord-280549-bsnz24jx	398	1	It	-PRON-	PRP
cord-280549-bsnz24jx	398	2	was	be	VBD
cord-280549-bsnz24jx	398	3	later	later	RB
cord-280549-bsnz24jx	398	4	discovered	discover	VBN
cord-280549-bsnz24jx	398	5	that	that	IN
cord-280549-bsnz24jx	398	6	p17	p17	NN
cord-280549-bsnz24jx	398	7	protein	protein	NN
cord-280549-bsnz24jx	398	8	of	of	IN
cord-280549-bsnz24jx	398	9	ARV	ARV	NNP
cord-280549-bsnz24jx	398	10	could	could	MD
cord-280549-bsnz24jx	398	11	robustly	robustly	RB
cord-280549-bsnz24jx	398	12	enhance	enhance	VB
cord-280549-bsnz24jx	398	13	MDM2	MDM2	NNP
cord-280549-bsnz24jx	398	14	binding	bind	VBG
cord-280549-bsnz24jx	398	15	to	to	IN
cord-280549-bsnz24jx	398	16	ribosomal	ribosomal	JJ
cord-280549-bsnz24jx	398	17	proteins	protein	NNS
cord-280549-bsnz24jx	398	18	,	,	,
cord-280549-bsnz24jx	398	19	thereby	thereby	RB
cord-280549-bsnz24jx	398	20	blocking	block	VBG
cord-280549-bsnz24jx	398	21	MDM2-mediated	mdm2-mediate	VBN
cord-280549-bsnz24jx	398	22	p53	p53	NN
cord-280549-bsnz24jx	398	23	ubiquitination	ubiquitination	NN
cord-280549-bsnz24jx	398	24	and	and	CC
cord-280549-bsnz24jx	398	25	degradation	degradation	NN
cord-280549-bsnz24jx	398	26	(	(	-LRB-
cord-280549-bsnz24jx	398	27	Zhang	Zhang	NNP
cord-280549-bsnz24jx	398	28	and	and	CC
cord-280549-bsnz24jx	398	29	Lu	Lu	NNP
cord-280549-bsnz24jx	398	30	,	,	,
cord-280549-bsnz24jx	398	31	2009	2009	CD
cord-280549-bsnz24jx	398	32	;	;	:
cord-280549-bsnz24jx	398	33	Huang	Huang	NNP
cord-280549-bsnz24jx	398	34	et	et	NNP
cord-280549-bsnz24jx	398	35	al	al	NNP
cord-280549-bsnz24jx	398	36	.	.	NNP
cord-280549-bsnz24jx	398	37	,	,	,
cord-280549-bsnz24jx	398	38	2017	2017	CD
cord-280549-bsnz24jx	398	39	)	)	-RRB-
cord-280549-bsnz24jx	398	40	.Thus	.Thus	NFP
cord-280549-bsnz24jx	398	41	,	,	,
cord-280549-bsnz24jx	398	42	through	through	IN
cord-280549-bsnz24jx	398	43	multiple	multiple	JJ
cord-280549-bsnz24jx	398	44	mechanisms	mechanism	NNS
cord-280549-bsnz24jx	398	45	,	,	,
cord-280549-bsnz24jx	398	46	ARV	ARV	NNP
cord-280549-bsnz24jx	398	47	impairs	impair	VBZ
cord-280549-bsnz24jx	398	48	the	the	DT
cord-280549-bsnz24jx	398	49	ability	ability	NN
cord-280549-bsnz24jx	398	50	of	of	IN
cord-280549-bsnz24jx	398	51	MDM2	MDM2	NNP
cord-280549-bsnz24jx	398	52	to	to	TO
cord-280549-bsnz24jx	398	53	target	target	VB
cord-280549-bsnz24jx	398	54	p53	p53	NN
cord-280549-bsnz24jx	398	55	for	for	IN
cord-280549-bsnz24jx	398	56	degradation	degradation	NN
cord-280549-bsnz24jx	398	57	.	.	.
cord-280549-bsnz24jx	399	1	There	there	EX
cord-280549-bsnz24jx	399	2	is	be	VBZ
cord-280549-bsnz24jx	399	3	evidence	evidence	NN
cord-280549-bsnz24jx	399	4	that	that	IN
cord-280549-bsnz24jx	399	5	both	both	CC
cord-280549-bsnz24jx	399	6	PTEN	PTEN	NNP
cord-280549-bsnz24jx	399	7	and	and	CC
cord-280549-bsnz24jx	399	8	p21	p21	NN
cord-280549-bsnz24jx	399	9	WAF1	WAF1	NNP
cord-280549-bsnz24jx	399	10	/	/	SYM
cord-280549-bsnz24jx	399	11	CIP1	CIP1	NNP
cord-280549-bsnz24jx	399	12	are	be	VBP
cord-280549-bsnz24jx	399	13	required	require	VBN
cord-280549-bsnz24jx	399	14	for	for	IN
cord-280549-bsnz24jx	399	15	p53-mediated	p53-mediated	JJ
cord-280549-bsnz24jx	399	16	cell	cell	NN
cord-280549-bsnz24jx	399	17	cycle	cycle	NN
cord-280549-bsnz24jx	399	18	arrest	arrest	NN
cord-280549-bsnz24jx	399	19	(	(	-LRB-
cord-280549-bsnz24jx	399	20	el	el	NNP
cord-280549-bsnz24jx	399	21	-	-	HYPH
cord-280549-bsnz24jx	399	22	Deiry	Deiry	NNP
cord-280549-bsnz24jx	399	23	et	et	NNP
cord-280549-bsnz24jx	399	24	al	al	NNP
cord-280549-bsnz24jx	399	25	.	.	NNP
cord-280549-bsnz24jx	399	26	,	,	,
cord-280549-bsnz24jx	399	27	1993	1993	CD
cord-280549-bsnz24jx	399	28	;	;	:
cord-280549-bsnz24jx	399	29	Stambolic	Stambolic	NNP
cord-280549-bsnz24jx	399	30	et	et	NNP
cord-280549-bsnz24jx	399	31	al	al	NNP
cord-280549-bsnz24jx	399	32	.	.	NNP
cord-280549-bsnz24jx	399	33	,	,	,
cord-280549-bsnz24jx	399	34	2001	2001	CD
cord-280549-bsnz24jx	399	35	)	)	-RRB-
cord-280549-bsnz24jx	399	36	,	,	,
cord-280549-bsnz24jx	399	37	which	which	WDT
cord-280549-bsnz24jx	399	38	is	be	VBZ
cord-280549-bsnz24jx	399	39	dependent	dependent	JJ
cord-280549-bsnz24jx	399	40	on	on	IN
cord-280549-bsnz24jx	399	41	a	a	DT
cord-280549-bsnz24jx	399	42	complex	complex	JJ
cord-280549-bsnz24jx	399	43	signaling	signaling	NN
cord-280549-bsnz24jx	399	44	cascade	cascade	NN
cord-280549-bsnz24jx	399	45	that	that	WDT
cord-280549-bsnz24jx	399	46	brings	bring	VBZ
cord-280549-bsnz24jx	399	47	about	about	RP
cord-280549-bsnz24jx	399	48	Akt	Akt	NNP
cord-280549-bsnz24jx	399	49	-	-	HYPH
cord-280549-bsnz24jx	399	50	induced	induce	VBN
cord-280549-bsnz24jx	399	51	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	399	52	of	of	IN
cord-280549-bsnz24jx	399	53	MDM2	MDM2	NNP
cord-280549-bsnz24jx	399	54	,	,	,
cord-280549-bsnz24jx	399	55	antagonized	antagonize	VBN
cord-280549-bsnz24jx	399	56	by	by	IN
cord-280549-bsnz24jx	399	57	PTEN	PTEN	NNP
cord-280549-bsnz24jx	399	58	,	,	,
cord-280549-bsnz24jx	399	59	and	and	CC
cord-280549-bsnz24jx	399	60	the	the	DT
cord-280549-bsnz24jx	399	61	ensuing	ensue	VBG
cord-280549-bsnz24jx	399	62	translocation	translocation	NN
cord-280549-bsnz24jx	399	63	of	of	IN
cord-280549-bsnz24jx	399	64	MDM2	MDM2	NNPS
cord-280549-bsnz24jx	399	65	to	to	IN
cord-280549-bsnz24jx	399	66	the	the	DT
cord-280549-bsnz24jx	399	67	nucleus	nucleus	NN
cord-280549-bsnz24jx	399	68	to	to	TO
cord-280549-bsnz24jx	399	69	downregulate	downregulate	VB
cord-280549-bsnz24jx	399	70	p53	p53	CD
cord-280549-bsnz24jx	399	71	(	(	-LRB-
cord-280549-bsnz24jx	399	72	Mayo	Mayo	NNP
cord-280549-bsnz24jx	399	73	and	and	CC
cord-280549-bsnz24jx	399	74	Donner	Donner	NNP
cord-280549-bsnz24jx	399	75	,	,	,
cord-280549-bsnz24jx	399	76	2002	2002	CD
cord-280549-bsnz24jx	399	77	)	)	-RRB-
cord-280549-bsnz24jx	399	78	.	.	.
cord-280549-bsnz24jx	400	1	Thus	thus	RB
cord-280549-bsnz24jx	400	2	,	,	,
cord-280549-bsnz24jx	400	3	the	the	DT
cord-280549-bsnz24jx	400	4	interplay	interplay	NN
cord-280549-bsnz24jx	400	5	between	between	IN
cord-280549-bsnz24jx	400	6	viruses	virus	NNS
cord-280549-bsnz24jx	400	7	and	and	CC
cord-280549-bsnz24jx	400	8	tumor	tumor	NN
cord-280549-bsnz24jx	400	9	suppressor	suppressor	NN
cord-280549-bsnz24jx	400	10	proteins	protein	NNS
cord-280549-bsnz24jx	400	11	is	be	VBZ
cord-280549-bsnz24jx	400	12	likely	likely	JJ
cord-280549-bsnz24jx	400	13	to	to	TO
cord-280549-bsnz24jx	400	14	target	target	VB
cord-280549-bsnz24jx	400	15	multiple	multiple	JJ
cord-280549-bsnz24jx	400	16	networks	network	NNS
cord-280549-bsnz24jx	400	17	that	that	WDT
cord-280549-bsnz24jx	400	18	ultimately	ultimately	RB
cord-280549-bsnz24jx	400	19	affect	affect	VBP
cord-280549-bsnz24jx	400	20	the	the	DT
cord-280549-bsnz24jx	400	21	cell	cell	NN
cord-280549-bsnz24jx	400	22	cycle	cycle	NN
cord-280549-bsnz24jx	400	23	.	.	.
cord-280549-bsnz24jx	401	1	The	the	DT
cord-280549-bsnz24jx	401	2	anaphase	anaphase	NN
cord-280549-bsnz24jx	401	3	promoting	promote	VBG
cord-280549-bsnz24jx	401	4	complex	complex	JJ
cord-280549-bsnz24jx	401	5	/	/	SYM
cord-280549-bsnz24jx	401	6	cyclosome	cyclosome	NNP
cord-280549-bsnz24jx	401	7	(	(	-LRB-
cord-280549-bsnz24jx	401	8	APC	APC	NNP
cord-280549-bsnz24jx	401	9	/	/	SYM
cord-280549-bsnz24jx	401	10	C	C	NNP
cord-280549-bsnz24jx	401	11	)	)	-RRB-
cord-280549-bsnz24jx	401	12	was	be	VBD
cord-280549-bsnz24jx	401	13	characterized	characterize	VBN
cord-280549-bsnz24jx	401	14	as	as	IN
cord-280549-bsnz24jx	401	15	a	a	DT
cord-280549-bsnz24jx	401	16	securin	securin	NN
cord-280549-bsnz24jx	401	17	-	-	:
cord-280549-bsnz24jx	401	18	and	and	CC
cord-280549-bsnz24jx	401	19	cyclin	cyclin	NN
cord-280549-bsnz24jx	401	20	B	b	NN
cord-280549-bsnz24jx	401	21	-	-	HYPH
cord-280549-bsnz24jx	401	22	specific	specific	JJ
cord-280549-bsnz24jx	401	23	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	401	24	ligase	ligase	NN
cord-280549-bsnz24jx	401	25	,	,	,
cord-280549-bsnz24jx	401	26	functioning	function	VBG
cord-280549-bsnz24jx	401	27	mainly	mainly	RB
cord-280549-bsnz24jx	401	28	to	to	TO
cord-280549-bsnz24jx	401	29	trigger	trigger	VB
cord-280549-bsnz24jx	401	30	metaphase	metaphase	NN
cord-280549-bsnz24jx	401	31	to	to	IN
cord-280549-bsnz24jx	401	32	anaphase	anaphase	NN
cord-280549-bsnz24jx	401	33	transition	transition	NN
cord-280549-bsnz24jx	401	34	by	by	IN
cord-280549-bsnz24jx	401	35	tagging	tag	VBG
cord-280549-bsnz24jx	401	36	these	these	DT
cord-280549-bsnz24jx	401	37	proteins	protein	NNS
cord-280549-bsnz24jx	401	38	for	for	IN
cord-280549-bsnz24jx	401	39	degradation	degradation	NN
cord-280549-bsnz24jx	402	1	(	(	-LRB-
cord-280549-bsnz24jx	402	2	Irniger	Irniger	NNP
cord-280549-bsnz24jx	402	3	et	et	NNP
cord-280549-bsnz24jx	402	4	al	al	NNP
cord-280549-bsnz24jx	402	5	.	.	.
cord-280549-bsnz24jx	403	1	,	,	,
cord-280549-bsnz24jx	403	2	1995	1995	CD
cord-280549-bsnz24jx	403	3	;	;	:
cord-280549-bsnz24jx	403	4	King	King	NNP
cord-280549-bsnz24jx	403	5	et	et	NNP
cord-280549-bsnz24jx	403	6	al	al	NNP
cord-280549-bsnz24jx	403	7	.	.	.
cord-280549-bsnz24jx	404	1	,	,	,
cord-280549-bsnz24jx	404	2	1995	1995	CD
cord-280549-bsnz24jx	404	3	;	;	:
cord-280549-bsnz24jx	404	4	Sudakin	Sudakin	NNP
cord-280549-bsnz24jx	404	5	et	et	NNP
cord-280549-bsnz24jx	404	6	al	al	NNP
cord-280549-bsnz24jx	404	7	.	.	NNP
cord-280549-bsnz24jx	404	8	,	,	,
cord-280549-bsnz24jx	404	9	1995	1995	CD
cord-280549-bsnz24jx	404	10	;	;	:
cord-280549-bsnz24jx	405	1	Thornton	Thornton	NNP
cord-280549-bsnz24jx	405	2	and	and	CC
cord-280549-bsnz24jx	405	3	Toczyski	Toczyski	NNP
cord-280549-bsnz24jx	405	4	,	,	,
cord-280549-bsnz24jx	405	5	2003	2003	CD
cord-280549-bsnz24jx	405	6	;	;	:
cord-280549-bsnz24jx	405	7	Peters	Peters	NNP
cord-280549-bsnz24jx	405	8	,	,	,
cord-280549-bsnz24jx	405	9	2006	2006	CD
cord-280549-bsnz24jx	405	10	)	)	-RRB-
cord-280549-bsnz24jx	405	11	.	.	.
cord-280549-bsnz24jx	406	1	Securin	Securin	NNP
cord-280549-bsnz24jx	406	2	sequesters	sequester	VBZ
cord-280549-bsnz24jx	406	3	separin	separin	NNP
cord-280549-bsnz24jx	406	4	,	,	,
cord-280549-bsnz24jx	406	5	the	the	DT
cord-280549-bsnz24jx	406	6	"	"	``
cord-280549-bsnz24jx	406	7	sister	sister	NN
cord-280549-bsnz24jx	406	8	-	-	HYPH
cord-280549-bsnz24jx	406	9	separating	separate	VBG
cord-280549-bsnz24jx	406	10	"	"	''
cord-280549-bsnz24jx	406	11	protease	protease	NN
cord-280549-bsnz24jx	406	12	,	,	,
cord-280549-bsnz24jx	406	13	preventing	prevent	VBG
cord-280549-bsnz24jx	406	14	the	the	DT
cord-280549-bsnz24jx	406	15	separation	separation	NN
cord-280549-bsnz24jx	406	16	and	and	CC
cord-280549-bsnz24jx	406	17	segregation	segregation	NN
cord-280549-bsnz24jx	406	18	of	of	IN
cord-280549-bsnz24jx	406	19	sister	sister	NN
cord-280549-bsnz24jx	406	20	chromatids	chromatid	NNS
cord-280549-bsnz24jx	406	21	(	(	-LRB-
cord-280549-bsnz24jx	406	22	Nasmyth	Nasmyth	NNP
cord-280549-bsnz24jx	406	23	et	et	NNP
cord-280549-bsnz24jx	406	24	al	al	NNP
cord-280549-bsnz24jx	406	25	.	.	NNP
cord-280549-bsnz24jx	406	26	,	,	,
cord-280549-bsnz24jx	406	27	2000	2000	CD
cord-280549-bsnz24jx	406	28	;	;	:
cord-280549-bsnz24jx	406	29	Yanagida	Yanagida	NNP
cord-280549-bsnz24jx	406	30	,	,	,
cord-280549-bsnz24jx	406	31	2000	2000	CD
cord-280549-bsnz24jx	406	32	)	)	-RRB-
cord-280549-bsnz24jx	406	33	.	.	.
cord-280549-bsnz24jx	407	1	Thus	thus	RB
cord-280549-bsnz24jx	407	2	,	,	,
cord-280549-bsnz24jx	407	3	the	the	DT
cord-280549-bsnz24jx	407	4	degradation	degradation	NN
cord-280549-bsnz24jx	407	5	of	of	IN
cord-280549-bsnz24jx	407	6	securin	securin	NNP
cord-280549-bsnz24jx	407	7	by	by	IN
cord-280549-bsnz24jx	407	8	APC	APC	NNP
cord-280549-bsnz24jx	407	9	/	/	SYM
cord-280549-bsnz24jx	407	10	C	C	NNP
cord-280549-bsnz24jx	407	11	is	be	VBZ
cord-280549-bsnz24jx	407	12	essential	essential	JJ
cord-280549-bsnz24jx	407	13	for	for	IN
cord-280549-bsnz24jx	407	14	the	the	DT
cord-280549-bsnz24jx	407	15	completion	completion	NN
cord-280549-bsnz24jx	407	16	of	of	IN
cord-280549-bsnz24jx	407	17	mitosis	mitosis	NN
cord-280549-bsnz24jx	407	18	,	,	,
cord-280549-bsnz24jx	407	19	leading	lead	VBG
cord-280549-bsnz24jx	407	20	to	to	IN
cord-280549-bsnz24jx	407	21	correct	correct	VB
cord-280549-bsnz24jx	407	22	transmission	transmission	NN
cord-280549-bsnz24jx	407	23	of	of	IN
cord-280549-bsnz24jx	407	24	chromosomes	chromosome	NNS
cord-280549-bsnz24jx	407	25	from	from	IN
cord-280549-bsnz24jx	407	26	mother	mother	NN
cord-280549-bsnz24jx	407	27	to	to	IN
cord-280549-bsnz24jx	407	28	daughter	daughter	NN
cord-280549-bsnz24jx	407	29	cells	cell	NNS
cord-280549-bsnz24jx	408	1	(	(	-LRB-
cord-280549-bsnz24jx	408	2	Zou	Zou	NNP
cord-280549-bsnz24jx	408	3	et	et	FW
cord-280549-bsnz24jx	408	4	al	al	NNP
cord-280549-bsnz24jx	408	5	.	.	NNP
cord-280549-bsnz24jx	408	6	,	,	,
cord-280549-bsnz24jx	408	7	1999	1999	CD
cord-280549-bsnz24jx	408	8	)	)	-RRB-
cord-280549-bsnz24jx	409	1	.The	.The	.
cord-280549-bsnz24jx	410	1	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	410	2	Tax	Tax	NNP
cord-280549-bsnz24jx	410	3	of	of	IN
cord-280549-bsnz24jx	410	4	HTLV-1	HTLV-1	NNP
cord-280549-bsnz24jx	410	5	is	be	VBZ
cord-280549-bsnz24jx	410	6	able	able	JJ
cord-280549-bsnz24jx	410	7	to	to	TO
cord-280549-bsnz24jx	410	8	promote	promote	VB
cord-280549-bsnz24jx	410	9	securin	securin	NN
cord-280549-bsnz24jx	410	10	and	and	CC
cord-280549-bsnz24jx	410	11	cyclin	cyclin	NN
cord-280549-bsnz24jx	410	12	B1	b1	NN
cord-280549-bsnz24jx	410	13	degradation	degradation	NN
cord-280549-bsnz24jx	410	14	,	,	,
cord-280549-bsnz24jx	410	15	a	a	DT
cord-280549-bsnz24jx	410	16	process	process	NN
cord-280549-bsnz24jx	410	17	which	which	WDT
cord-280549-bsnz24jx	410	18	requires	require	VBZ
cord-280549-bsnz24jx	410	19	the	the	DT
cord-280549-bsnz24jx	410	20	function	function	NN
cord-280549-bsnz24jx	410	21	of	of	IN
cord-280549-bsnz24jx	410	22	the	the	DT
cord-280549-bsnz24jx	410	23	accessory	accessory	NN
cord-280549-bsnz24jx	410	24	factor	factor	NN
cord-280549-bsnz24jx	410	25	CDC20	CDC20	NNP
cord-280549-bsnz24jx	410	26	of	of	IN
cord-280549-bsnz24jx	410	27	APC	APC	NNP
cord-280549-bsnz24jx	410	28	,	,	,
cord-280549-bsnz24jx	410	29	leading	lead	VBG
cord-280549-bsnz24jx	410	30	to	to	IN
cord-280549-bsnz24jx	410	31	chromosome	chromosome	NN
cord-280549-bsnz24jx	410	32	instability	instability	NN
cord-280549-bsnz24jx	410	33	(	(	-LRB-
cord-280549-bsnz24jx	410	34	Liu	Liu	NNP
cord-280549-bsnz24jx	410	35	et	et	NNP
cord-280549-bsnz24jx	410	36	al	al	NNP
cord-280549-bsnz24jx	410	37	.	.	NNP
cord-280549-bsnz24jx	410	38	,	,	,
cord-280549-bsnz24jx	410	39	2003	2003	CD
cord-280549-bsnz24jx	410	40	)	)	-RRB-
cord-280549-bsnz24jx	410	41	.	.	.
cord-280549-bsnz24jx	411	1	Although	although	IN
cord-280549-bsnz24jx	411	2	the	the	DT
cord-280549-bsnz24jx	411	3	mechanism	mechanism	NN
cord-280549-bsnz24jx	411	4	by	by	IN
cord-280549-bsnz24jx	411	5	which	which	WDT
cord-280549-bsnz24jx	411	6	Tax	Tax	NNP
cord-280549-bsnz24jx	411	7	activates	activate	VBZ
cord-280549-bsnz24jx	411	8	APC	APC	NNP
cord-280549-bsnz24jx	411	9	is	be	VBZ
cord-280549-bsnz24jx	411	10	still	still	RB
cord-280549-bsnz24jx	411	11	unclear	unclear	JJ
cord-280549-bsnz24jx	411	12	,	,	,
cord-280549-bsnz24jx	411	13	an	an	DT
cord-280549-bsnz24jx	411	14	association	association	NN
cord-280549-bsnz24jx	411	15	of	of	IN
cord-280549-bsnz24jx	411	16	Tax	Tax	NNP
cord-280549-bsnz24jx	411	17	with	with	IN
cord-280549-bsnz24jx	411	18	APC	APC	NNP
cord-280549-bsnz24jx	411	19	CDC20	CDC20	NNP
cord-280549-bsnz24jx	411	20	was	be	VBD
cord-280549-bsnz24jx	411	21	reported	report	VBN
cord-280549-bsnz24jx	412	1	(	(	-LRB-
cord-280549-bsnz24jx	412	2	Liu	Liu	NNP
cord-280549-bsnz24jx	412	3	et	et	NNP
cord-280549-bsnz24jx	412	4	al	al	NNP
cord-280549-bsnz24jx	412	5	.	.	NNP
cord-280549-bsnz24jx	412	6	,	,	,
cord-280549-bsnz24jx	412	7	2005	2005	CD
cord-280549-bsnz24jx	412	8	)	)	-RRB-
cord-280549-bsnz24jx	412	9	.	.	.
cord-280549-bsnz24jx	413	1	Interestingly	interestingly	RB
cord-280549-bsnz24jx	413	2	,	,	,
cord-280549-bsnz24jx	413	3	premature	premature	JJ
cord-280549-bsnz24jx	413	4	activation	activation	NN
cord-280549-bsnz24jx	413	5	of	of	IN
cord-280549-bsnz24jx	413	6	APC	APC	NNP
cord-280549-bsnz24jx	413	7	by	by	IN
cord-280549-bsnz24jx	413	8	Tax	Tax	NNP
cord-280549-bsnz24jx	413	9	could	could	MD
cord-280549-bsnz24jx	413	10	also	also	RB
cord-280549-bsnz24jx	413	11	result	result	VB
cord-280549-bsnz24jx	413	12	in	in	IN
cord-280549-bsnz24jx	413	13	a	a	DT
cord-280549-bsnz24jx	413	14	surge	surge	NN
cord-280549-bsnz24jx	413	15	in	in	IN
cord-280549-bsnz24jx	413	16	the	the	DT
cord-280549-bsnz24jx	413	17	levels	level	NNS
cord-280549-bsnz24jx	413	18	of	of	IN
cord-280549-bsnz24jx	413	19	p21	p21	NN
cord-280549-bsnz24jx	413	20	WAF1	WAF1	NNP
cord-280549-bsnz24jx	413	21	/	/	SYM
cord-280549-bsnz24jx	413	22	CIP1	CIP1	NNP
cord-280549-bsnz24jx	413	23	and	and	CC
cord-280549-bsnz24jx	413	24	p27	p27	NN
cord-280549-bsnz24jx	413	25	KIP1	KIP1	NNP
cord-280549-bsnz24jx	413	26	,	,	,
cord-280549-bsnz24jx	413	27	leading	lead	VBG
cord-280549-bsnz24jx	413	28	to	to	IN
cord-280549-bsnz24jx	413	29	G1	G1	NNP
cord-280549-bsnz24jx	413	30	arrest	arrest	NN
cord-280549-bsnz24jx	413	31	that	that	WDT
cord-280549-bsnz24jx	413	32	resembles	resemble	VBZ
cord-280549-bsnz24jx	413	33	cellular	cellular	JJ
cord-280549-bsnz24jx	413	34	senescence	senescence	NN
cord-280549-bsnz24jx	413	35	(	(	-LRB-
cord-280549-bsnz24jx	413	36	Kuo	Kuo	NNP
cord-280549-bsnz24jx	413	37	and	and	CC
cord-280549-bsnz24jx	413	38	Giam	Giam	NNP
cord-280549-bsnz24jx	413	39	,	,	,
cord-280549-bsnz24jx	413	40	2006	2006	CD
cord-280549-bsnz24jx	413	41	)	)	-RRB-
cord-280549-bsnz24jx	413	42	.	.	.
cord-280549-bsnz24jx	414	1	This	this	DT
cord-280549-bsnz24jx	414	2	was	be	VBD
cord-280549-bsnz24jx	414	3	found	find	VBN
cord-280549-bsnz24jx	414	4	to	to	TO
cord-280549-bsnz24jx	414	5	be	be	VB
cord-280549-bsnz24jx	414	6	a	a	DT
cord-280549-bsnz24jx	414	7	result	result	NN
cord-280549-bsnz24jx	414	8	of	of	IN
cord-280549-bsnz24jx	414	9	polyubiquitination	polyubiquitination	NN
cord-280549-bsnz24jx	414	10	and	and	CC
cord-280549-bsnz24jx	414	11	degradation	degradation	NN
cord-280549-bsnz24jx	414	12	of	of	IN
cord-280549-bsnz24jx	414	13	Skp2	Skp2	NNP
cord-280549-bsnz24jx	414	14	,	,	,
cord-280549-bsnz24jx	414	15	the	the	DT
cord-280549-bsnz24jx	414	16	substrate	substrate	NN
cord-280549-bsnz24jx	414	17	recognition	recognition	NN
cord-280549-bsnz24jx	414	18	subunit	subunit	NN
cord-280549-bsnz24jx	414	19	of	of	IN
cord-280549-bsnz24jx	414	20	the	the	DT
cord-280549-bsnz24jx	414	21	SCF	SCF	NNP
cord-280549-bsnz24jx	414	22	Skp2	Skp2	NNP
cord-280549-bsnz24jx	414	23	E3	e3	NN
cord-280549-bsnz24jx	414	24	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	414	25	ligase	ligase	NN
cord-280549-bsnz24jx	414	26	that	that	WDT
cord-280549-bsnz24jx	414	27	regulates	regulate	VBZ
cord-280549-bsnz24jx	414	28	the	the	DT
cord-280549-bsnz24jx	414	29	destruction	destruction	NN
cord-280549-bsnz24jx	414	30	of	of	IN
cord-280549-bsnz24jx	414	31	p21	p21	NN
cord-280549-bsnz24jx	414	32	WAF1	WAF1	NNP
cord-280549-bsnz24jx	414	33	/	/	SYM
cord-280549-bsnz24jx	414	34	CIP1	CIP1	NNP
cord-280549-bsnz24jx	414	35	and	and	CC
cord-280549-bsnz24jx	414	36	p27	p27	NN
cord-280549-bsnz24jx	414	37	KIP1	KIP1	NNP
cord-280549-bsnz24jx	414	38	,	,	,
cord-280549-bsnz24jx	414	39	by	by	IN
cord-280549-bsnz24jx	414	40	Tax	tax	NN
cord-280549-bsnz24jx	414	41	-	-	HYPH
cord-280549-bsnz24jx	414	42	activated	activate	VBN
cord-280549-bsnz24jx	414	43	APC	APC	NNP
cord-280549-bsnz24jx	415	1	(	(	-LRB-
cord-280549-bsnz24jx	415	2	Carrano	Carrano	NNP
cord-280549-bsnz24jx	415	3	et	et	NNP
cord-280549-bsnz24jx	415	4	al	al	NNP
cord-280549-bsnz24jx	415	5	.	.	NNP
cord-280549-bsnz24jx	415	6	,	,	,
cord-280549-bsnz24jx	415	7	1999	1999	CD
cord-280549-bsnz24jx	415	8	;	;	:
cord-280549-bsnz24jx	415	9	Nakayama	Nakayama	NNP
cord-280549-bsnz24jx	415	10	et	et	NNP
cord-280549-bsnz24jx	415	11	al	al	NNP
cord-280549-bsnz24jx	415	12	.	.	NNP
cord-280549-bsnz24jx	415	13	,	,	,
cord-280549-bsnz24jx	415	14	2004	2004	CD
cord-280549-bsnz24jx	415	15	;	;	:
cord-280549-bsnz24jx	416	1	Kuo	Kuo	NNP
cord-280549-bsnz24jx	416	2	and	and	CC
cord-280549-bsnz24jx	416	3	Giam	Giam	NNP
cord-280549-bsnz24jx	416	4	,	,	,
cord-280549-bsnz24jx	416	5	2006	2006	CD
cord-280549-bsnz24jx	416	6	)	)	-RRB-
cord-280549-bsnz24jx	416	7	.	.	.
cord-280549-bsnz24jx	417	1	Thus	thus	RB
cord-280549-bsnz24jx	417	2	,	,	,
cord-280549-bsnz24jx	417	3	by	by	IN
cord-280549-bsnz24jx	417	4	targeting	target	VBG
cord-280549-bsnz24jx	417	5	the	the	DT
cord-280549-bsnz24jx	417	6	E3	E3	NNP
cord-280549-bsnz24jx	417	7	ligase	ligase	NN
cord-280549-bsnz24jx	417	8	of	of	IN
cord-280549-bsnz24jx	417	9	p21	p21	NN
cord-280549-bsnz24jx	417	10	WAF1	WAF1	NNP
cord-280549-bsnz24jx	417	11	/	/	SYM
cord-280549-bsnz24jx	417	12	CIP1	CIP1	NNP
cord-280549-bsnz24jx	417	13	and	and	CC
cord-280549-bsnz24jx	417	14	p27	p27	NN
cord-280549-bsnz24jx	417	15	KIP1	KIP1	NNP
cord-280549-bsnz24jx	417	16	for	for	IN
cord-280549-bsnz24jx	417	17	degradation	degradation	NN
cord-280549-bsnz24jx	417	18	,	,	,
cord-280549-bsnz24jx	417	19	Tax	tax	NN
cord-280549-bsnz24jx	417	20	stabilizes	stabilize	VBZ
cord-280549-bsnz24jx	417	21	these	these	DT
cord-280549-bsnz24jx	417	22	two	two	CD
cord-280549-bsnz24jx	417	23	CKIs	cki	NNS
cord-280549-bsnz24jx	417	24	.	.	.
cord-280549-bsnz24jx	418	1	On	on	IN
cord-280549-bsnz24jx	418	2	the	the	DT
cord-280549-bsnz24jx	418	3	contrary	contrary	NN
cord-280549-bsnz24jx	418	4	,	,	,
cord-280549-bsnz24jx	418	5	the	the	DT
cord-280549-bsnz24jx	418	6	association	association	NNP
cord-280549-bsnz24jx	418	7	of	of	IN
cord-280549-bsnz24jx	418	8	chicken	chicken	NNP
cord-280549-bsnz24jx	418	9	anemia	anemia	NN
cord-280549-bsnz24jx	418	10	virus	virus	NN
cord-280549-bsnz24jx	418	11	protein	protein	NN
cord-280549-bsnz24jx	418	12	Apoptin	Apoptin	NNP
cord-280549-bsnz24jx	418	13	with	with	IN
cord-280549-bsnz24jx	418	14	APC1	APC1	NNP
cord-280549-bsnz24jx	418	15	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	418	16	the	the	DT
cord-280549-bsnz24jx	418	17	activity	activity	NN
cord-280549-bsnz24jx	418	18	of	of	IN
cord-280549-bsnz24jx	418	19	theAPC	theAPC	NNP
cord-280549-bsnz24jx	418	20	/	/	SYM
cord-280549-bsnz24jx	418	21	C	c	NN
cord-280549-bsnz24jx	418	22	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	418	23	ligase	ligase	NN
cord-280549-bsnz24jx	418	24	,	,	,
cord-280549-bsnz24jx	418	25	leading	lead	VBG
cord-280549-bsnz24jx	418	26	to	to	IN
cord-280549-bsnz24jx	418	27	the	the	DT
cord-280549-bsnz24jx	418	28	stabilization	stabilization	NN
cord-280549-bsnz24jx	418	29	of	of	IN
cord-280549-bsnz24jx	418	30	cyclin	cyclin	NN
cord-280549-bsnz24jx	418	31	B1	b1	NN
cord-280549-bsnz24jx	418	32	and	and	CC
cord-280549-bsnz24jx	418	33	other	other	JJ
cord-280549-bsnz24jx	418	34	APC	APC	NNP
cord-280549-bsnz24jx	418	35	/	/	SYM
cord-280549-bsnz24jx	418	36	C	C	NNP
cord-280549-bsnz24jx	418	37	substrates	substrate	NNS
cord-280549-bsnz24jx	418	38	,	,	,
cord-280549-bsnz24jx	418	39	with	with	IN
cord-280549-bsnz24jx	418	40	ensuing	ensue	VBG
cord-280549-bsnz24jx	418	41	cell	cell	NN
cord-280549-bsnz24jx	418	42	cycle	cycle	NN
cord-280549-bsnz24jx	418	43	G2	G2	NNP
cord-280549-bsnz24jx	418	44	/	/	SYM
cord-280549-bsnz24jx	418	45	M	M	NNP
cord-280549-bsnz24jx	418	46	arrest	arrest	NN
cord-280549-bsnz24jx	418	47	and	and	CC
cord-280549-bsnz24jx	418	48	apoptosis	apoptosis	NN
cord-280549-bsnz24jx	419	1	(	(	-LRB-
cord-280549-bsnz24jx	419	2	Teodoro	Teodoro	NNP
cord-280549-bsnz24jx	419	3	et	et	NNP
cord-280549-bsnz24jx	419	4	al	al	NNP
cord-280549-bsnz24jx	419	5	.	.	NNP
cord-280549-bsnz24jx	419	6	,	,	,
cord-280549-bsnz24jx	419	7	2004	2004	CD
cord-280549-bsnz24jx	419	8	)	)	-RRB-
cord-280549-bsnz24jx	419	9	.	.	.
cord-280549-bsnz24jx	420	1	The	the	DT
cord-280549-bsnz24jx	420	2	deubiquitinase	deubiquitinase	NN
cord-280549-bsnz24jx	420	3	(	(	-LRB-
cord-280549-bsnz24jx	420	4	DUB	dub	NN
cord-280549-bsnz24jx	420	5	)	)	-RRB-
cord-280549-bsnz24jx	420	6	USP37	usp37	WP
cord-280549-bsnz24jx	420	7	has	have	VBZ
cord-280549-bsnz24jx	420	8	been	be	VBN
cord-280549-bsnz24jx	420	9	found	find	VBN
cord-280549-bsnz24jx	420	10	to	to	TO
cord-280549-bsnz24jx	420	11	stabilize	stabilize	VB
cord-280549-bsnz24jx	420	12	cyclin	cyclin	NN
cord-280549-bsnz24jx	420	13	A	a	NN
cord-280549-bsnz24jx	420	14	by	by	IN
cord-280549-bsnz24jx	420	15	removing	remove	VBG
cord-280549-bsnz24jx	420	16	the	the	DT
cord-280549-bsnz24jx	420	17	polyubiquitin	polyubiquitin	NNS
cord-280549-bsnz24jx	420	18	from	from	IN
cord-280549-bsnz24jx	420	19	the	the	DT
cord-280549-bsnz24jx	420	20	latter	latter	JJ
cord-280549-bsnz24jx	420	21	and	and	CC
cord-280549-bsnz24jx	420	22	,	,	,
cord-280549-bsnz24jx	420	23	hence	hence	RB
cord-280549-bsnz24jx	420	24	,	,	,
cord-280549-bsnz24jx	420	25	accelerates	accelerate	VBZ
cord-280549-bsnz24jx	420	26	entry	entry	NN
cord-280549-bsnz24jx	420	27	into	into	IN
cord-280549-bsnz24jx	420	28	S	s	NN
cord-280549-bsnz24jx	420	29	phase	phase	NN
cord-280549-bsnz24jx	421	1	(	(	-LRB-
cord-280549-bsnz24jx	421	2	Huang	Huang	NNP
cord-280549-bsnz24jx	421	3	et	et	NNP
cord-280549-bsnz24jx	421	4	al	al	NNP
cord-280549-bsnz24jx	421	5	.	.	NNP
cord-280549-bsnz24jx	421	6	,	,	,
cord-280549-bsnz24jx	421	7	2011	2011	CD
cord-280549-bsnz24jx	421	8	)	)	-RRB-
cord-280549-bsnz24jx	421	9	.	.	.
cord-280549-bsnz24jx	422	1	HBx	HBx	NNP
cord-280549-bsnz24jx	422	2	of	of	IN
cord-280549-bsnz24jx	422	3	HBV	HBV	NNP
cord-280549-bsnz24jx	422	4	could	could	MD
cord-280549-bsnz24jx	422	5	upregulate	upregulate	VB
cord-280549-bsnz24jx	422	6	USP37	usp37	$
cord-280549-bsnz24jx	422	7	transcripts	transcript	NNS
cord-280549-bsnz24jx	422	8	in	in	IN
cord-280549-bsnz24jx	422	9	both	both	CC
cord-280549-bsnz24jx	422	10	hepatic	hepatic	JJ
cord-280549-bsnz24jx	422	11	and	and	CC
cord-280549-bsnz24jx	422	12	non	non	JJ
cord-280549-bsnz24jx	422	13	-	-	JJ
cord-280549-bsnz24jx	422	14	hepatic	hepatic	JJ
cord-280549-bsnz24jx	422	15	cells	cell	NNS
cord-280549-bsnz24jx	422	16	and	and	CC
cord-280549-bsnz24jx	422	17	also	also	RB
cord-280549-bsnz24jx	422	18	prevents	prevent	VBZ
cord-280549-bsnz24jx	422	19	USP37	usp37	RB
cord-280549-bsnz24jx	422	20	from	from	IN
cord-280549-bsnz24jx	422	21	proteasomal	proteasomal	JJ
cord-280549-bsnz24jx	422	22	degradation	degradation	NN
cord-280549-bsnz24jx	422	23	.	.	.
cord-280549-bsnz24jx	423	1	HBx	HBx	NNP
cord-280549-bsnz24jx	423	2	acts	act	VBZ
cord-280549-bsnz24jx	423	3	as	as	IN
cord-280549-bsnz24jx	423	4	a	a	DT
cord-280549-bsnz24jx	423	5	chaperone	chaperone	NN
cord-280549-bsnz24jx	423	6	of	of	IN
cord-280549-bsnz24jx	423	7	USP37	USP37	NNP
cord-280549-bsnz24jx	423	8	and	and	CC
cord-280549-bsnz24jx	423	9	shuttles	shuttle	VBZ
cord-280549-bsnz24jx	423	10	it	-PRON-	PRP
cord-280549-bsnz24jx	423	11	out	out	IN
cord-280549-bsnz24jx	423	12	of	of	IN
cord-280549-bsnz24jx	423	13	the	the	DT
cord-280549-bsnz24jx	423	14	nucleus	nucleus	NN
cord-280549-bsnz24jx	423	15	,	,	,
cord-280549-bsnz24jx	423	16	where	where	WRB
cord-280549-bsnz24jx	423	17	the	the	DT
cord-280549-bsnz24jx	423	18	ubiquitin	ubiquitin	JJ
cord-280549-bsnz24jx	423	19	E3	e3	NN
cord-280549-bsnz24jx	423	20	ligase	ligase	NN
cord-280549-bsnz24jx	423	21	CDC20	CDC20	NNP
cord-280549-bsnz24jx	423	22	homolog	homolog	NN
cord-280549-bsnz24jx	423	23	Lin	Lin	NNP
cord-280549-bsnz24jx	423	24	et	et	NNP
cord-280549-bsnz24jx	423	25	al	al	NNP
cord-280549-bsnz24jx	423	26	.	.	NNP
cord-280549-bsnz24jx	423	27	,	,	,
cord-280549-bsnz24jx	423	28	2009	2009	CD
cord-280549-bsnz24jx	423	29	of	of	IN
cord-280549-bsnz24jx	423	30	the	the	DT
cord-280549-bsnz24jx	423	31	large	large	JJ
cord-280549-bsnz24jx	423	32	protease	protease	NN
cord-280549-bsnz24jx	423	33	complex	complex	NN
cord-280549-bsnz24jx	423	34	γ	γ	NN
cord-280549-bsnz24jx	423	35	-	-	HYPH
cord-280549-bsnz24jx	423	36	secretase	secretase	NNP
cord-280549-bsnz24jx	423	37	which	which	WDT
cord-280549-bsnz24jx	423	38	mediates	mediate	VBZ
cord-280549-bsnz24jx	423	39	the	the	DT
cord-280549-bsnz24jx	423	40	cleavage	cleavage	NN
cord-280549-bsnz24jx	423	41	of	of	IN
cord-280549-bsnz24jx	423	42	Notch	notch	NN
cord-280549-bsnz24jx	423	43	1	1	CD
cord-280549-bsnz24jx	423	44	(	(	-LRB-
cord-280549-bsnz24jx	423	45	Artavanis-	artavanis-	XX
cord-280549-bsnz24jx	424	1	Tsakonas	Tsakonas	NNP
cord-280549-bsnz24jx	424	2	et	et	NNP
cord-280549-bsnz24jx	424	3	al	al	NNP
cord-280549-bsnz24jx	424	4	.	.	NNP
cord-280549-bsnz24jx	424	5	,	,	,
cord-280549-bsnz24jx	424	6	1999	1999	CD
cord-280549-bsnz24jx	424	7	;	;	:
cord-280549-bsnz24jx	424	8	Kopan	Kopan	NNP
cord-280549-bsnz24jx	424	9	and	and	CC
cord-280549-bsnz24jx	424	10	Ilagan	Ilagan	NNP
cord-280549-bsnz24jx	424	11	,	,	,
cord-280549-bsnz24jx	424	12	2009	2009	CD
cord-280549-bsnz24jx	424	13	;	;	:
cord-280549-bsnz24jx	424	14	Xu	Xu	NNP
cord-280549-bsnz24jx	424	15	et	et	NNP
cord-280549-bsnz24jx	424	16	al	al	NNP
cord-280549-bsnz24jx	424	17	.	.	NNP
cord-280549-bsnz24jx	424	18	,	,	,
cord-280549-bsnz24jx	424	19	2010	2010	CD
cord-280549-bsnz24jx	424	20	)	)	-RRB-
cord-280549-bsnz24jx	424	21	.	.	.
cord-280549-bsnz24jx	425	1	In	in	IN
cord-280549-bsnz24jx	425	2	addition	addition	NN
cord-280549-bsnz24jx	425	3	to	to	IN
cord-280549-bsnz24jx	425	4	hijacking	hijack	VBG
cord-280549-bsnz24jx	425	5	the	the	DT
cord-280549-bsnz24jx	425	6	host	host	NN
cord-280549-bsnz24jx	425	7	ubiquitination	ubiquitination	NN
cord-280549-bsnz24jx	425	8	machinery	machinery	NN
cord-280549-bsnz24jx	425	9	,	,	,
cord-280549-bsnz24jx	425	10	viruses	virus	NNS
cord-280549-bsnz24jx	425	11	could	could	MD
cord-280549-bsnz24jx	425	12	also	also	RB
cord-280549-bsnz24jx	425	13	encode	encode	VB
cord-280549-bsnz24jx	425	14	their	-PRON-	PRP$
cord-280549-bsnz24jx	425	15	own	own	JJ
cord-280549-bsnz24jx	425	16	degradation	degradation	NN
cord-280549-bsnz24jx	425	17	enzymes	enzyme	NNS
cord-280549-bsnz24jx	425	18	.	.	.
cord-280549-bsnz24jx	426	1	The	the	DT
cord-280549-bsnz24jx	426	2	zinc	zinc	NN
cord-280549-bsnz24jx	426	3	-	-	HYPH
cord-280549-bsnz24jx	426	4	binding	bind	VBG
cord-280549-bsnz24jx	426	5	RING	ring	NN
cord-280549-bsnz24jx	426	6	finger	finger	NN
cord-280549-bsnz24jx	426	7	domain	domain	NN
cord-280549-bsnz24jx	426	8	of	of	IN
cord-280549-bsnz24jx	426	9	ICP0	ICP0	NNP
cord-280549-bsnz24jx	426	10	of	of	IN
cord-280549-bsnz24jx	426	11	HSV-1	HSV-1	NNP
cord-280549-bsnz24jx	426	12	possesses	possess	VBZ
cord-280549-bsnz24jx	426	13	a	a	DT
cord-280549-bsnz24jx	426	14	ubiquitin	ubiquitin	JJ
cord-280549-bsnz24jx	426	15	E3	e3	NN
cord-280549-bsnz24jx	426	16	ligase	ligase	NN
cord-280549-bsnz24jx	426	17	activity	activity	NN
cord-280549-bsnz24jx	426	18	(	(	-LRB-
cord-280549-bsnz24jx	426	19	Boutell	Boutell	NNP
cord-280549-bsnz24jx	426	20	et	et	FW
cord-280549-bsnz24jx	426	21	al	al	NNP
cord-280549-bsnz24jx	426	22	.	.	NNP
cord-280549-bsnz24jx	426	23	,	,	,
cord-280549-bsnz24jx	426	24	2002	2002	CD
cord-280549-bsnz24jx	426	25	;	;	:
cord-280549-bsnz24jx	426	26	Hagglund	Hagglund	NNP
cord-280549-bsnz24jx	426	27	et	et	FW
cord-280549-bsnz24jx	426	28	al	al	NNP
cord-280549-bsnz24jx	426	29	.	.	NNP
cord-280549-bsnz24jx	426	30	,	,	,
cord-280549-bsnz24jx	426	31	2002	2002	CD
cord-280549-bsnz24jx	426	32	)	)	-RRB-
cord-280549-bsnz24jx	426	33	.	.	.
cord-280549-bsnz24jx	427	1	Sole	sole	JJ
cord-280549-bsnz24jx	427	2	expression	expression	NN
cord-280549-bsnz24jx	427	3	of	of	IN
cord-280549-bsnz24jx	427	4	ICP0	ICP0	NNP
cord-280549-bsnz24jx	427	5	is	be	VBZ
cord-280549-bsnz24jx	427	6	able	able	JJ
cord-280549-bsnz24jx	427	7	to	to	TO
cord-280549-bsnz24jx	427	8	induce	induce	VB
cord-280549-bsnz24jx	427	9	rapid	rapid	JJ
cord-280549-bsnz24jx	427	10	loss	loss	NN
cord-280549-bsnz24jx	427	11	of	of	IN
cord-280549-bsnz24jx	427	12	the	the	DT
cord-280549-bsnz24jx	427	13	centromeric	centromeric	JJ
cord-280549-bsnz24jx	427	14	protein	protein	NN
cord-280549-bsnz24jx	427	15	CENP	CENP	NNP
cord-280549-bsnz24jx	427	16	-	-	HYPH
cord-280549-bsnz24jx	427	17	C	C	NNP
cord-280549-bsnz24jx	427	18	and	and	CC
cord-280549-bsnz24jx	427	19	CENP	CENP	NNP
cord-280549-bsnz24jx	427	20	-	-	HYPH
cord-280549-bsnz24jx	427	21	A	a	NN
cord-280549-bsnz24jx	427	22	in	in	IN
cord-280549-bsnz24jx	427	23	a	a	DT
cord-280549-bsnz24jx	427	24	proteasome	proteasome	NN
cord-280549-bsnz24jx	427	25	-	-	HYPH
cord-280549-bsnz24jx	427	26	dependent	dependent	JJ
cord-280549-bsnz24jx	427	27	manner	manner	NN
cord-280549-bsnz24jx	427	28	,	,	,
cord-280549-bsnz24jx	427	29	resulting	result	VBG
cord-280549-bsnz24jx	427	30	in	in	IN
cord-280549-bsnz24jx	427	31	mitotic	mitotic	JJ
cord-280549-bsnz24jx	427	32	block	block	NN
cord-280549-bsnz24jx	428	1	(	(	-LRB-
cord-280549-bsnz24jx	428	2	Everett	Everett	NNP
cord-280549-bsnz24jx	428	3	et	et	NNP
cord-280549-bsnz24jx	428	4	al	al	NNP
cord-280549-bsnz24jx	428	5	.	.	NNP
cord-280549-bsnz24jx	428	6	,	,	,
cord-280549-bsnz24jx	428	7	1999	1999	CD
cord-280549-bsnz24jx	429	1	;	;	:
cord-280549-bsnz24jx	429	2	Lomonte	Lomonte	NNP
cord-280549-bsnz24jx	429	3	et	et	FW
cord-280549-bsnz24jx	429	4	al	al	NNP
cord-280549-bsnz24jx	429	5	.	.	NNP
cord-280549-bsnz24jx	429	6	,	,	,
cord-280549-bsnz24jx	429	7	2001	2001	CD
cord-280549-bsnz24jx	429	8	)	)	-RRB-
cord-280549-bsnz24jx	429	9	.	.	.
cord-280549-bsnz24jx	430	1	However	however	RB
cord-280549-bsnz24jx	430	2	,	,	,
cord-280549-bsnz24jx	430	3	it	-PRON-	PRP
cord-280549-bsnz24jx	430	4	remains	remain	VBZ
cord-280549-bsnz24jx	430	5	unclear	unclear	JJ
cord-280549-bsnz24jx	430	6	whether	whether	IN
cord-280549-bsnz24jx	430	7	these	these	DT
cord-280549-bsnz24jx	430	8	two	two	CD
cord-280549-bsnz24jx	430	9	centromere	centromere	NN
cord-280549-bsnz24jx	430	10	components	component	NNS
cord-280549-bsnz24jx	430	11	are	be	VBP
cord-280549-bsnz24jx	430	12	direct	direct	JJ
cord-280549-bsnz24jx	430	13	substrates	substrate	NNS
cord-280549-bsnz24jx	430	14	of	of	IN
cord-280549-bsnz24jx	430	15	the	the	DT
cord-280549-bsnz24jx	430	16	ICP0	ICP0	NNP
cord-280549-bsnz24jx	430	17	E3	E3	NNP
cord-280549-bsnz24jx	430	18	ligase	ligase	NN
cord-280549-bsnz24jx	430	19	.	.	.
cord-280549-bsnz24jx	431	1	The	the	DT
cord-280549-bsnz24jx	431	2	use	use	NN
cord-280549-bsnz24jx	431	3	of	of	IN
cord-280549-bsnz24jx	431	4	purified	purify	VBN
cord-280549-bsnz24jx	431	5	p53	p53	NN
cord-280549-bsnz24jx	431	6	in	in	IN
cord-280549-bsnz24jx	431	7	the	the	DT
cord-280549-bsnz24jx	431	8	presence	presence	NN
cord-280549-bsnz24jx	431	9	of	of	IN
cord-280549-bsnz24jx	431	10	ICP0	ICP0	NNP
cord-280549-bsnz24jx	431	11	,	,	,
cord-280549-bsnz24jx	431	12	together	together	RB
cord-280549-bsnz24jx	431	13	with	with	IN
cord-280549-bsnz24jx	431	14	a	a	DT
cord-280549-bsnz24jx	431	15	full	full	JJ
cord-280549-bsnz24jx	431	16	complement	complement	NN
cord-280549-bsnz24jx	431	17	of	of	IN
cord-280549-bsnz24jx	431	18	the	the	DT
cord-280549-bsnz24jx	431	19	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	431	20	-	-	HYPH
cord-280549-bsnz24jx	431	21	conjugating	conjugate	VBG
cord-280549-bsnz24jx	431	22	enzymes	enzyme	NNS
cord-280549-bsnz24jx	431	23	in	in	IN
cord-280549-bsnz24jx	431	24	test	test	NN
cord-280549-bsnz24jx	431	25	tubes	tube	NNS
cord-280549-bsnz24jx	431	26	,	,	,
cord-280549-bsnz24jx	431	27	revealed	reveal	VBD
cord-280549-bsnz24jx	431	28	a	a	DT
cord-280549-bsnz24jx	431	29	direct	direct	JJ
cord-280549-bsnz24jx	431	30	ubiquitination	ubiquitination	NN
cord-280549-bsnz24jx	431	31	of	of	IN
cord-280549-bsnz24jx	431	32	p53	p53	NN
cord-280549-bsnz24jx	431	33	by	by	IN
cord-280549-bsnz24jx	431	34	ICP0	ICP0	NNP
cord-280549-bsnz24jx	432	1	(	(	-LRB-
cord-280549-bsnz24jx	432	2	Boutell	Boutell	NNP
cord-280549-bsnz24jx	432	3	and	and	CC
cord-280549-bsnz24jx	432	4	Everett	Everett	NNP
cord-280549-bsnz24jx	432	5	,	,	,
cord-280549-bsnz24jx	432	6	2003	2003	CD
cord-280549-bsnz24jx	432	7	)	)	-RRB-
cord-280549-bsnz24jx	432	8	;	;	:
cord-280549-bsnz24jx	432	9	p53	p53	NN
cord-280549-bsnz24jx	432	10	levels	level	NNS
cord-280549-bsnz24jx	432	11	,	,	,
cord-280549-bsnz24jx	432	12	howver	howver	RB
cord-280549-bsnz24jx	432	13	,	,	,
cord-280549-bsnz24jx	432	14	were	be	VBD
cord-280549-bsnz24jx	432	15	not	not	RB
cord-280549-bsnz24jx	432	16	reduced	reduce	VBN
cord-280549-bsnz24jx	432	17	during	during	IN
cord-280549-bsnz24jx	432	18	HSV-1	hsv-1	NN
cord-280549-bsnz24jx	432	19	infection	infection	NN
cord-280549-bsnz24jx	432	20	and	and	CC
cord-280549-bsnz24jx	432	21	,	,	,
cord-280549-bsnz24jx	432	22	hence	hence	RB
cord-280549-bsnz24jx	432	23	,	,	,
cord-280549-bsnz24jx	432	24	the	the	DT
cord-280549-bsnz24jx	432	25	role	role	NN
cord-280549-bsnz24jx	432	26	of	of	IN
cord-280549-bsnz24jx	432	27	p53	p53	NN
cord-280549-bsnz24jx	432	28	in	in	IN
cord-280549-bsnz24jx	432	29	ICP0-induced	icp0-induce	VBN
cord-280549-bsnz24jx	432	30	perturbation	perturbation	NN
cord-280549-bsnz24jx	432	31	of	of	IN
cord-280549-bsnz24jx	432	32	cell	cell	NN
cord-280549-bsnz24jx	432	33	cycle	cycle	NN
cord-280549-bsnz24jx	432	34	progression	progression	NN
cord-280549-bsnz24jx	432	35	and	and	CC
cord-280549-bsnz24jx	432	36	accumulation	accumulation	NN
cord-280549-bsnz24jx	432	37	in	in	IN
cord-280549-bsnz24jx	432	38	G1	G1	NNP
cord-280549-bsnz24jx	432	39	/	/	SYM
cord-280549-bsnz24jx	432	40	S	S	NNP
cord-280549-bsnz24jx	432	41	and	and	CC
cord-280549-bsnz24jx	432	42	G2	G2	NNP
cord-280549-bsnz24jx	432	43	/	/	SYM
cord-280549-bsnz24jx	432	44	M	M	NNP
cord-280549-bsnz24jx	432	45	needs	need	VBZ
cord-280549-bsnz24jx	432	46	further	further	JJ
cord-280549-bsnz24jx	432	47	investigation	investigation	NN
cord-280549-bsnz24jx	432	48	(	(	-LRB-
cord-280549-bsnz24jx	432	49	Hobbs	Hobbs	NNP
cord-280549-bsnz24jx	432	50	and	and	CC
cord-280549-bsnz24jx	432	51	DeLuca	DeLuca	NNP
cord-280549-bsnz24jx	432	52	,	,	,
cord-280549-bsnz24jx	432	53	1999	1999	CD
cord-280549-bsnz24jx	432	54	)	)	-RRB-
cord-280549-bsnz24jx	432	55	.	.	.
cord-280549-bsnz24jx	433	1	Still	still	RB
cord-280549-bsnz24jx	433	2	,	,	,
cord-280549-bsnz24jx	433	3	it	-PRON-	PRP
cord-280549-bsnz24jx	433	4	provides	provide	VBZ
cord-280549-bsnz24jx	433	5	a	a	DT
cord-280549-bsnz24jx	433	6	novel	novel	JJ
cord-280549-bsnz24jx	433	7	mechanism	mechanism	NN
cord-280549-bsnz24jx	433	8	by	by	IN
cord-280549-bsnz24jx	433	9	which	which	WDT
cord-280549-bsnz24jx	433	10	a	a	DT
cord-280549-bsnz24jx	433	11	virus	virus	NN
cord-280549-bsnz24jx	433	12	-	-	HYPH
cord-280549-bsnz24jx	433	13	encoded	encode	VBN
cord-280549-bsnz24jx	433	14	protein	protein	NN
cord-280549-bsnz24jx	433	15	functions	function	NNS
cord-280549-bsnz24jx	433	16	as	as	IN
cord-280549-bsnz24jx	433	17	an	an	DT
cord-280549-bsnz24jx	433	18	E3	e3	NN
cord-280549-bsnz24jx	433	19	ligase	ligase	NN
cord-280549-bsnz24jx	433	20	to	to	TO
cord-280549-bsnz24jx	433	21	catalyze	catalyze	VB
cord-280549-bsnz24jx	433	22	the	the	DT
cord-280549-bsnz24jx	433	23	degradation	degradation	NN
cord-280549-bsnz24jx	433	24	of	of	IN
cord-280549-bsnz24jx	433	25	cell	cell	NN
cord-280549-bsnz24jx	433	26	cycle	cycle	NN
cord-280549-bsnz24jx	433	27	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	433	28	proteins	protein	NNS
cord-280549-bsnz24jx	433	29	.	.	.
cord-280549-bsnz24jx	434	1	Acute	acute	JJ
cord-280549-bsnz24jx	434	2	Japanese	japanese	JJ
cord-280549-bsnz24jx	434	3	encephalitis	encephalitis	RB
cord-280549-bsnz24jx	434	4	virus	virus	NN
cord-280549-bsnz24jx	434	5	(	(	-LRB-
cord-280549-bsnz24jx	434	6	JEV	JEV	NNP
cord-280549-bsnz24jx	434	7	)	)	-RRB-
cord-280549-bsnz24jx	434	8	infection	infection	NN
cord-280549-bsnz24jx	434	9	leads	lead	VBZ
cord-280549-bsnz24jx	434	10	to	to	IN
cord-280549-bsnz24jx	434	11	cell	cell	NN
cord-280549-bsnz24jx	434	12	cycle	cycle	NN
cord-280549-bsnz24jx	434	13	G0	G0	NNP
cord-280549-bsnz24jx	434	14	/	/	SYM
cord-280549-bsnz24jx	434	15	G1	G1	NNP
cord-280549-bsnz24jx	434	16	arrest	arrest	NN
cord-280549-bsnz24jx	434	17	with	with	IN
cord-280549-bsnz24jx	434	18	elevated	elevated	JJ
cord-280549-bsnz24jx	434	19	p21	p21	NN
cord-280549-bsnz24jx	434	20	WAF1	WAF1	NNP
cord-280549-bsnz24jx	434	21	/	/	SYM
cord-280549-bsnz24jx	434	22	CIP1	CIP1	NNP
cord-280549-bsnz24jx	434	23	and	and	CC
cord-280549-bsnz24jx	434	24	p27	p27	NN
cord-280549-bsnz24jx	434	25	KIP1	KIP1	NNP
cord-280549-bsnz24jx	434	26	levels	level	NNS
cord-280549-bsnz24jx	434	27	,	,	,
cord-280549-bsnz24jx	434	28	and	and	CC
cord-280549-bsnz24jx	434	29	reduced	reduce	VBN
cord-280549-bsnz24jx	434	30	production	production	NN
cord-280549-bsnz24jx	434	31	of	of	IN
cord-280549-bsnz24jx	434	32	cyclin	cyclin	NN
cord-280549-bsnz24jx	434	33	D	d	NN
cord-280549-bsnz24jx	434	34	(	(	-LRB-
cord-280549-bsnz24jx	434	35	Das	Das	NNP
cord-280549-bsnz24jx	434	36	and	and	CC
cord-280549-bsnz24jx	434	37	Basu	Basu	NNP
cord-280549-bsnz24jx	434	38	,	,	,
cord-280549-bsnz24jx	434	39	2008	2008	CD
cord-280549-bsnz24jx	434	40	)	)	-RRB-
cord-280549-bsnz24jx	434	41	.	.	.
cord-280549-bsnz24jx	435	1	However	however	RB
cord-280549-bsnz24jx	435	2	,	,	,
cord-280549-bsnz24jx	435	3	in	in	IN
cord-280549-bsnz24jx	435	4	the	the	DT
cord-280549-bsnz24jx	435	5	case	case	NN
cord-280549-bsnz24jx	435	6	of	of	IN
cord-280549-bsnz24jx	435	7	persistent	persistent	JJ
cord-280549-bsnz24jx	435	8	JEV	JEV	NNP
cord-280549-bsnz24jx	435	9	infection	infection	NN
cord-280549-bsnz24jx	435	10	,	,	,
cord-280549-bsnz24jx	435	11	expression	expression	NN
cord-280549-bsnz24jx	435	12	of	of	IN
cord-280549-bsnz24jx	435	13	these	these	DT
cord-280549-bsnz24jx	435	14	CKIs	cki	NNS
cord-280549-bsnz24jx	435	15	and	and	CC
cord-280549-bsnz24jx	435	16	GSK-3β	GSK-3β	NNP
cord-280549-bsnz24jx	435	17	,	,	,
cord-280549-bsnz24jx	435	18	which	which	WDT
cord-280549-bsnz24jx	435	19	mediates	mediate	VBZ
cord-280549-bsnz24jx	435	20	the	the	DT
cord-280549-bsnz24jx	435	21	degradation	degradation	NN
cord-280549-bsnz24jx	435	22	of	of	IN
cord-280549-bsnz24jx	435	23	cyclin	cyclin	NN
cord-280549-bsnz24jx	435	24	D	d	NN
cord-280549-bsnz24jx	435	25	,	,	,
cord-280549-bsnz24jx	435	26	is	be	VBZ
cord-280549-bsnz24jx	435	27	suppressed	suppress	VBN
cord-280549-bsnz24jx	436	1	(	(	-LRB-
cord-280549-bsnz24jx	436	2	Diehl	Diehl	NNP
cord-280549-bsnz24jx	436	3	et	et	NNP
cord-280549-bsnz24jx	436	4	al	al	NNP
cord-280549-bsnz24jx	436	5	.	.	.
cord-280549-bsnz24jx	437	1	,	,	,
cord-280549-bsnz24jx	437	2	1998	1998	CD
cord-280549-bsnz24jx	437	3	;	;	:
cord-280549-bsnz24jx	437	4	Kim	Kim	NNP
cord-280549-bsnz24jx	437	5	et	et	NNP
cord-280549-bsnz24jx	437	6	al	al	NNP
cord-280549-bsnz24jx	437	7	.	.	NNP
cord-280549-bsnz24jx	437	8	,	,	,
cord-280549-bsnz24jx	437	9	2015	2015	CD
cord-280549-bsnz24jx	437	10	)	)	-RRB-
cord-280549-bsnz24jx	437	11	.	.	.
cord-280549-bsnz24jx	438	1	Thus	thus	RB
cord-280549-bsnz24jx	438	2	,	,	,
cord-280549-bsnz24jx	438	3	by	by	IN
cord-280549-bsnz24jx	438	4	extending	extend	VBG
cord-280549-bsnz24jx	438	5	the	the	DT
cord-280549-bsnz24jx	438	6	stability	stability	NN
cord-280549-bsnz24jx	438	7	of	of	IN
cord-280549-bsnz24jx	438	8	cyclin	cyclin	NN
cord-280549-bsnz24jx	438	9	D	d	NN
cord-280549-bsnz24jx	438	10	,	,	,
cord-280549-bsnz24jx	438	11	persistent	persistent	JJ
cord-280549-bsnz24jx	438	12	JEV	JEV	NNP
cord-280549-bsnz24jx	438	13	infection	infection	NN
cord-280549-bsnz24jx	438	14	bypasses	bypass	VBZ
cord-280549-bsnz24jx	438	15	cell	cell	NN
cord-280549-bsnz24jx	438	16	cycle	cycle	NN
cord-280549-bsnz24jx	438	17	arrest	arrest	NN
cord-280549-bsnz24jx	438	18	,	,	,
cord-280549-bsnz24jx	438	19	striking	strike	VBG
cord-280549-bsnz24jx	438	20	a	a	DT
cord-280549-bsnz24jx	438	21	balance	balance	NN
cord-280549-bsnz24jx	438	22	between	between	IN
cord-280549-bsnz24jx	438	23	the	the	DT
cord-280549-bsnz24jx	438	24	persistence	persistence	NN
cord-280549-bsnz24jx	438	25	of	of	IN
cord-280549-bsnz24jx	438	26	lytic	lytic	JJ
cord-280549-bsnz24jx	438	27	RNA	RNA	NNP
cord-280549-bsnz24jx	438	28	virus	virus	NN
cord-280549-bsnz24jx	438	29	and	and	CC
cord-280549-bsnz24jx	438	30	host	host	NN
cord-280549-bsnz24jx	438	31	survival	survival	NN
cord-280549-bsnz24jx	438	32	.	.	.
cord-280549-bsnz24jx	439	1	Enterovirus	enterovirus	NN
cord-280549-bsnz24jx	439	2	71	71	CD
cord-280549-bsnz24jx	439	3	(	(	-LRB-
cord-280549-bsnz24jx	439	4	EV71	EV71	NNP
cord-280549-bsnz24jx	439	5	)	)	-RRB-
cord-280549-bsnz24jx	439	6	,	,	,
cord-280549-bsnz24jx	439	7	the	the	DT
cord-280549-bsnz24jx	439	8	etiological	etiological	JJ
cord-280549-bsnz24jx	439	9	agent	agent	NN
cord-280549-bsnz24jx	439	10	of	of	IN
cord-280549-bsnz24jx	439	11	hand	hand	NN
cord-280549-bsnz24jx	439	12	,	,	,
cord-280549-bsnz24jx	439	13	foot	foot	NN
cord-280549-bsnz24jx	439	14	,	,	,
cord-280549-bsnz24jx	439	15	and	and	CC
cord-280549-bsnz24jx	439	16	mouth	mouth	NN
cord-280549-bsnz24jx	439	17	disease	disease	NN
cord-280549-bsnz24jx	439	18	,	,	,
cord-280549-bsnz24jx	439	19	was	be	VBD
cord-280549-bsnz24jx	439	20	shown	show	VBN
cord-280549-bsnz24jx	439	21	to	to	TO
cord-280549-bsnz24jx	439	22	prevent	prevent	VB
cord-280549-bsnz24jx	439	23	cell	cell	NN
cord-280549-bsnz24jx	439	24	cycle	cycle	NN
cord-280549-bsnz24jx	439	25	transition	transition	NN
cord-280549-bsnz24jx	439	26	from	from	IN
cord-280549-bsnz24jx	439	27	S	S	NNP
cord-280549-bsnz24jx	439	28	to	to	IN
cord-280549-bsnz24jx	439	29	G2	G2	NNP
cord-280549-bsnz24jx	439	30	/	/	SYM
cord-280549-bsnz24jx	439	31	M	M	NNP
cord-280549-bsnz24jx	439	32	phase	phase	NN
cord-280549-bsnz24jx	440	1	(	(	-LRB-
cord-280549-bsnz24jx	440	2	Ooi	Ooi	NNP
cord-280549-bsnz24jx	440	3	et	et	NNP
cord-280549-bsnz24jx	440	4	al	al	NNP
cord-280549-bsnz24jx	440	5	.	.	NNP
cord-280549-bsnz24jx	440	6	,	,	,
cord-280549-bsnz24jx	440	7	2007	2007	CD
cord-280549-bsnz24jx	441	1	;	;	:
cord-280549-bsnz24jx	441	2	Yu	Yu	NNP
cord-280549-bsnz24jx	441	3	et	et	NNP
cord-280549-bsnz24jx	441	4	al	al	NNP
cord-280549-bsnz24jx	441	5	.	.	NNP
cord-280549-bsnz24jx	441	6	,	,	,
cord-280549-bsnz24jx	441	7	2015	2015	CD
cord-280549-bsnz24jx	441	8	)	)	-RRB-
cord-280549-bsnz24jx	441	9	.	.	.
cord-280549-bsnz24jx	442	1	Although	although	IN
cord-280549-bsnz24jx	442	2	the	the	DT
cord-280549-bsnz24jx	442	3	molecular	molecular	JJ
cord-280549-bsnz24jx	442	4	mechanisms	mechanism	NNS
cord-280549-bsnz24jx	442	5	is	be	VBZ
cord-280549-bsnz24jx	442	6	still	still	RB
cord-280549-bsnz24jx	442	7	unclear	unclear	JJ
cord-280549-bsnz24jx	442	8	,	,	,
cord-280549-bsnz24jx	442	9	it	-PRON-	PRP
cord-280549-bsnz24jx	442	10	was	be	VBD
cord-280549-bsnz24jx	442	11	observed	observe	VBN
cord-280549-bsnz24jx	442	12	that	that	IN
cord-280549-bsnz24jx	442	13	cyclin	cyclin	NN
cord-280549-bsnz24jx	442	14	A2	A2	NNP
cord-280549-bsnz24jx	442	15	was	be	VBD
cord-280549-bsnz24jx	442	16	targeted	target	VBN
cord-280549-bsnz24jx	442	17	for	for	IN
cord-280549-bsnz24jx	442	18	proteasome	proteasome	NN
cord-280549-bsnz24jx	442	19	-	-	HYPH
cord-280549-bsnz24jx	442	20	mediated	mediate	VBN
cord-280549-bsnz24jx	442	21	degradation	degradation	NN
cord-280549-bsnz24jx	442	22	during	during	IN
cord-280549-bsnz24jx	442	23	infection	infection	NN
cord-280549-bsnz24jx	442	24	(	(	-LRB-
cord-280549-bsnz24jx	442	25	Yu	Yu	NNP
cord-280549-bsnz24jx	442	26	et	et	FW
cord-280549-bsnz24jx	442	27	al	al	NNP
cord-280549-bsnz24jx	442	28	.	.	NNP
cord-280549-bsnz24jx	442	29	,	,	,
cord-280549-bsnz24jx	442	30	2015	2015	CD
cord-280549-bsnz24jx	442	31	)	)	-RRB-
cord-280549-bsnz24jx	442	32	.	.	.
cord-280549-bsnz24jx	443	1	While	while	IN
cord-280549-bsnz24jx	443	2	it	-PRON-	PRP
cord-280549-bsnz24jx	443	3	is	be	VBZ
cord-280549-bsnz24jx	443	4	well	well	RB
cord-280549-bsnz24jx	443	5	established	establish	VBN
cord-280549-bsnz24jx	443	6	that	that	IN
cord-280549-bsnz24jx	443	7	several	several	JJ
cord-280549-bsnz24jx	443	8	biochemical	biochemical	JJ
cord-280549-bsnz24jx	443	9	processes	process	NNS
cord-280549-bsnz24jx	443	10	serve	serve	VBP
cord-280549-bsnz24jx	443	11	to	to	TO
cord-280549-bsnz24jx	443	12	orchestrate	orchestrate	VB
cord-280549-bsnz24jx	443	13	cell	cell	NN
cord-280549-bsnz24jx	443	14	cycle	cycle	NN
cord-280549-bsnz24jx	443	15	control	control	NN
cord-280549-bsnz24jx	443	16	,	,	,
cord-280549-bsnz24jx	443	17	including	include	VBG
cord-280549-bsnz24jx	443	18	proteinprotein	proteinprotein	NNP
cord-280549-bsnz24jx	443	19	interaction	interaction	NN
cord-280549-bsnz24jx	443	20	and	and	CC
cord-280549-bsnz24jx	443	21	dissociation	dissociation	NN
cord-280549-bsnz24jx	443	22	,	,	,
cord-280549-bsnz24jx	443	23	phosphorylation/	phosphorylation/	CD
cord-280549-bsnz24jx	443	24	dephosphorylation	dephosphorylation	NN
cord-280549-bsnz24jx	443	25	,	,	,
cord-280549-bsnz24jx	443	26	and	and	CC
cord-280549-bsnz24jx	443	27	the	the	DT
cord-280549-bsnz24jx	443	28	synthesis/	synthesis/	CD
cord-280549-bsnz24jx	443	29	destruction	destruction	NN
cord-280549-bsnz24jx	443	30	of	of	IN
cord-280549-bsnz24jx	443	31	cell	cell	NN
cord-280549-bsnz24jx	443	32	cycle	cycle	NN
cord-280549-bsnz24jx	443	33	regulators	regulator	NNS
cord-280549-bsnz24jx	443	34	at	at	IN
cord-280549-bsnz24jx	443	35	specific	specific	JJ
cord-280549-bsnz24jx	443	36	time	time	NN
cord-280549-bsnz24jx	443	37	point	point	NN
cord-280549-bsnz24jx	443	38	,	,	,
cord-280549-bsnz24jx	443	39	the	the	DT
cord-280549-bsnz24jx	443	40	importance	importance	NN
cord-280549-bsnz24jx	443	41	of	of	IN
cord-280549-bsnz24jx	443	42	subcellular	subcellular	JJ
cord-280549-bsnz24jx	443	43	localization	localization	NN
cord-280549-bsnz24jx	443	44	of	of	IN
cord-280549-bsnz24jx	443	45	CDK	CDK	NNP
cord-280549-bsnz24jx	443	46	-	-	HYPH
cord-280549-bsnz24jx	443	47	cyclins	cyclin	NNS
cord-280549-bsnz24jx	443	48	complexes	complex	NNS
cord-280549-bsnz24jx	443	49	and	and	CC
cord-280549-bsnz24jx	443	50	their	-PRON-	PRP$
cord-280549-bsnz24jx	443	51	regulators	regulator	NNS
cord-280549-bsnz24jx	443	52	is	be	VBZ
cord-280549-bsnz24jx	443	53	receiving	receive	VBG
cord-280549-bsnz24jx	443	54	increasing	increase	VBG
cord-280549-bsnz24jx	443	55	attention	attention	NN
cord-280549-bsnz24jx	443	56	for	for	IN
cord-280549-bsnz24jx	443	57	proper	proper	JJ
cord-280549-bsnz24jx	443	58	cell	cell	NN
cord-280549-bsnz24jx	443	59	-	-	HYPH
cord-280549-bsnz24jx	443	60	cycle	cycle	NN
cord-280549-bsnz24jx	443	61	coordination	coordination	NN
cord-280549-bsnz24jx	443	62	.	.	.
cord-280549-bsnz24jx	444	1	Hence	hence	RB
cord-280549-bsnz24jx	444	2	,	,	,
cord-280549-bsnz24jx	444	3	viruses	virus	NNS
cord-280549-bsnz24jx	444	4	have	have	VBP
cord-280549-bsnz24jx	444	5	also	also	RB
cord-280549-bsnz24jx	444	6	evolved	evolve	VBN
cord-280549-bsnz24jx	444	7	mechanisms	mechanism	NNS
cord-280549-bsnz24jx	444	8	to	to	TO
cord-280549-bsnz24jx	444	9	deregulate	deregulate	VB
cord-280549-bsnz24jx	444	10	cell	cell	NN
cord-280549-bsnz24jx	444	11	cycle	cycle	NN
cord-280549-bsnz24jx	444	12	progression	progression	NN
cord-280549-bsnz24jx	444	13	by	by	IN
cord-280549-bsnz24jx	444	14	targeting	target	VBG
cord-280549-bsnz24jx	444	15	the	the	DT
cord-280549-bsnz24jx	444	16	localization	localization	NN
cord-280549-bsnz24jx	444	17	of	of	IN
cord-280549-bsnz24jx	444	18	cell	cell	NN
cord-280549-bsnz24jx	444	19	cycle	cycle	NN
cord-280549-bsnz24jx	444	20	regulators	regulator	NNS
cord-280549-bsnz24jx	444	21	.	.	.
cord-280549-bsnz24jx	445	1	One	one	CD
cord-280549-bsnz24jx	445	2	early	early	JJ
cord-280549-bsnz24jx	445	3	example	example	NN
cord-280549-bsnz24jx	445	4	of	of	IN
cord-280549-bsnz24jx	445	5	virus	virus	NN
cord-280549-bsnz24jx	445	6	-	-	HYPH
cord-280549-bsnz24jx	445	7	induced	induce	VBN
cord-280549-bsnz24jx	445	8	translocation	translocation	NN
cord-280549-bsnz24jx	445	9	of	of	IN
cord-280549-bsnz24jx	445	10	cell	cell	NN
cord-280549-bsnz24jx	445	11	cycle	cycle	NN
cord-280549-bsnz24jx	445	12	regulators	regulator	NNS
cord-280549-bsnz24jx	445	13	is	be	VBZ
cord-280549-bsnz24jx	445	14	exemplified	exemplify	VBN
cord-280549-bsnz24jx	445	15	by	by	IN
cord-280549-bsnz24jx	445	16	HCMV	HCMV	NNP
cord-280549-bsnz24jx	445	17	infection	infection	NN
cord-280549-bsnz24jx	445	18	,	,	,
cord-280549-bsnz24jx	445	19	which	which	WDT
cord-280549-bsnz24jx	445	20	can	can	MD
cord-280549-bsnz24jx	445	21	mitogenically	mitogenically	RB
cord-280549-bsnz24jx	445	22	stimulate	stimulate	VB
cord-280549-bsnz24jx	445	23	growth	growth	NN
cord-280549-bsnz24jx	445	24	-	-	HYPH
cord-280549-bsnz24jx	445	25	arrested	arrest	VBN
cord-280549-bsnz24jx	445	26	cells	cell	NNS
cord-280549-bsnz24jx	445	27	to	to	TO
cord-280549-bsnz24jx	445	28	enter	enter	VB
cord-280549-bsnz24jx	445	29	the	the	DT
cord-280549-bsnz24jx	445	30	cell	cell	NN
cord-280549-bsnz24jx	445	31	cycle	cycle	NN
cord-280549-bsnz24jx	445	32	by	by	IN
cord-280549-bsnz24jx	445	33	promoting	promote	VBG
cord-280549-bsnz24jx	445	34	nuclear	nuclear	JJ
cord-280549-bsnz24jx	445	35	uptake	uptake	NN
cord-280549-bsnz24jx	445	36	of	of	IN
cord-280549-bsnz24jx	445	37	CDK2	CDK2	NNP
cord-280549-bsnz24jx	445	38	(	(	-LRB-
cord-280549-bsnz24jx	445	39	Bresnahan	Bresnahan	NNP
cord-280549-bsnz24jx	445	40	et	et	NNP
cord-280549-bsnz24jx	445	41	al	al	NNP
cord-280549-bsnz24jx	445	42	.	.	NNP
cord-280549-bsnz24jx	445	43	,	,	,
cord-280549-bsnz24jx	445	44	FIGURE	figure	NN
cord-280549-bsnz24jx	445	45	3	3	CD
cord-280549-bsnz24jx	445	46	|	|	NNP
cord-280549-bsnz24jx	445	47	Cell	cell	NN
cord-280549-bsnz24jx	445	48	cycle	cycle	NN
cord-280549-bsnz24jx	445	49	subversion	subversion	NN
cord-280549-bsnz24jx	445	50	by	by	IN
cord-280549-bsnz24jx	445	51	protein	protein	NN
cord-280549-bsnz24jx	445	52	degradation	degradation	NN
cord-280549-bsnz24jx	445	53	.	.	.
cord-280549-bsnz24jx	446	1	(	(	-LRB-
cord-280549-bsnz24jx	446	2	A	a	DT
cord-280549-bsnz24jx	446	3	)	)	-RRB-
cord-280549-bsnz24jx	446	4	Expression	expression	NN
cord-280549-bsnz24jx	446	5	of	of	IN
cord-280549-bsnz24jx	446	6	(	(	-LRB-
cord-280549-bsnz24jx	446	7	Vif	vif	NN
cord-280549-bsnz24jx	446	8	)	)	-RRB-
cord-280549-bsnz24jx	446	9	protein	protein	NN
cord-280549-bsnz24jx	446	10	of	of	IN
cord-280549-bsnz24jx	446	11	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	446	12	blocks	block	VBZ
cord-280549-bsnz24jx	446	13	MDM2-mediated	mdm2-mediated	JJ
cord-280549-bsnz24jx	446	14	proteasomal	proteasomal	JJ
cord-280549-bsnz24jx	446	15	degradation	degradation	NN
cord-280549-bsnz24jx	446	16	of	of	IN
cord-280549-bsnz24jx	446	17	p53	p53	NN
cord-280549-bsnz24jx	446	18	,	,	,
cord-280549-bsnz24jx	446	19	by	by	IN
cord-280549-bsnz24jx	446	20	binding	bind	VBG
cord-280549-bsnz24jx	446	21	to	to	IN
cord-280549-bsnz24jx	446	22	both	both	DT
cord-280549-bsnz24jx	446	23	MDM2	MDM2	NNPS
cord-280549-bsnz24jx	446	24	and	and	CC
cord-280549-bsnz24jx	446	25	p53	p53	NN
cord-280549-bsnz24jx	446	26	,	,	,
cord-280549-bsnz24jx	446	27	leading	lead	VBG
cord-280549-bsnz24jx	446	28	to	to	IN
cord-280549-bsnz24jx	446	29	cell	cell	NN
cord-280549-bsnz24jx	446	30	cycle	cycle	NN
cord-280549-bsnz24jx	446	31	arrest	arrest	NN
cord-280549-bsnz24jx	446	32	in	in	IN
cord-280549-bsnz24jx	446	33	G2	G2	NNP
cord-280549-bsnz24jx	446	34	(	(	-LRB-
cord-280549-bsnz24jx	446	35	Izumi	Izumi	NNP
cord-280549-bsnz24jx	446	36	et	et	FW
cord-280549-bsnz24jx	446	37	al	al	NNP
cord-280549-bsnz24jx	446	38	.	.	NNP
cord-280549-bsnz24jx	446	39	,	,	,
cord-280549-bsnz24jx	446	40	2010	2010	CD
cord-280549-bsnz24jx	446	41	)	)	-RRB-
cord-280549-bsnz24jx	446	42	.	.	.
cord-280549-bsnz24jx	447	1	(	(	-LRB-
cord-280549-bsnz24jx	447	2	B	b	NN
cord-280549-bsnz24jx	447	3	)	)	-RRB-
cord-280549-bsnz24jx	448	1	The	the	DT
cord-280549-bsnz24jx	448	2	degradation	degradation	NN
cord-280549-bsnz24jx	448	3	of	of	IN
cord-280549-bsnz24jx	448	4	securin	securin	NNP
cord-280549-bsnz24jx	448	5	by	by	IN
cord-280549-bsnz24jx	448	6	the	the	DT
cord-280549-bsnz24jx	448	7	anaphase	anaphase	NN
cord-280549-bsnz24jx	448	8	promoting	promote	VBG
cord-280549-bsnz24jx	448	9	complex	complex	JJ
cord-280549-bsnz24jx	448	10	/	/	SYM
cord-280549-bsnz24jx	448	11	cyclosome	cyclosome	NNP
cord-280549-bsnz24jx	448	12	(	(	-LRB-
cord-280549-bsnz24jx	448	13	APC	APC	NNP
cord-280549-bsnz24jx	448	14	/	/	SYM
cord-280549-bsnz24jx	448	15	C	C	NNP
cord-280549-bsnz24jx	448	16	)	)	-RRB-
cord-280549-bsnz24jx	448	17	is	be	VBZ
cord-280549-bsnz24jx	448	18	essential	essential	JJ
cord-280549-bsnz24jx	448	19	for	for	IN
cord-280549-bsnz24jx	448	20	the	the	DT
cord-280549-bsnz24jx	448	21	completion	completion	NN
cord-280549-bsnz24jx	448	22	of	of	IN
cord-280549-bsnz24jx	448	23	mitosis	mitosis	NN
cord-280549-bsnz24jx	448	24	,	,	,
cord-280549-bsnz24jx	448	25	leading	lead	VBG
cord-280549-bsnz24jx	448	26	to	to	IN
cord-280549-bsnz24jx	448	27	correct	correct	VB
cord-280549-bsnz24jx	448	28	transmission	transmission	NN
cord-280549-bsnz24jx	448	29	of	of	IN
cord-280549-bsnz24jx	448	30	chromosomes	chromosome	NNS
cord-280549-bsnz24jx	448	31	from	from	IN
cord-280549-bsnz24jx	448	32	mother	mother	NN
cord-280549-bsnz24jx	448	33	to	to	IN
cord-280549-bsnz24jx	448	34	daughter	daughter	NN
cord-280549-bsnz24jx	448	35	cells	cell	NNS
cord-280549-bsnz24jx	448	36	.	.	.
cord-280549-bsnz24jx	449	1	The	the	DT
cord-280549-bsnz24jx	449	2	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	449	3	Tax	Tax	NNP
cord-280549-bsnz24jx	449	4	of	of	IN
cord-280549-bsnz24jx	449	5	HTLV-1	HTLV-1	NNP
cord-280549-bsnz24jx	449	6	is	be	VBZ
cord-280549-bsnz24jx	449	7	able	able	JJ
cord-280549-bsnz24jx	449	8	to	to	TO
cord-280549-bsnz24jx	449	9	promote	promote	VB
cord-280549-bsnz24jx	449	10	securin	securin	NN
cord-280549-bsnz24jx	449	11	and	and	CC
cord-280549-bsnz24jx	449	12	cyclin	cyclin	NN
cord-280549-bsnz24jx	449	13	B1	b1	NN
cord-280549-bsnz24jx	449	14	degradation	degradation	NN
cord-280549-bsnz24jx	449	15	,	,	,
cord-280549-bsnz24jx	449	16	leading	lead	VBG
cord-280549-bsnz24jx	449	17	to	to	IN
cord-280549-bsnz24jx	449	18	chromosome	chromosome	NN
cord-280549-bsnz24jx	449	19	instability	instability	NN
cord-280549-bsnz24jx	449	20	(	(	-LRB-
cord-280549-bsnz24jx	449	21	Liu	Liu	NNP
cord-280549-bsnz24jx	449	22	et	et	NNP
cord-280549-bsnz24jx	449	23	al	al	NNP
cord-280549-bsnz24jx	449	24	.	.	NNP
cord-280549-bsnz24jx	449	25	,	,	,
cord-280549-bsnz24jx	449	26	2003	2003	CD
cord-280549-bsnz24jx	449	27	)	)	-RRB-
cord-280549-bsnz24jx	449	28	.	.	.
cord-280549-bsnz24jx	450	1	(	(	-LRB-
cord-280549-bsnz24jx	450	2	C	C	NNP
cord-280549-bsnz24jx	450	3	)	)	-RRB-
cord-280549-bsnz24jx	450	4	ICP0	ICP0	NNP
cord-280549-bsnz24jx	450	5	of	of	IN
cord-280549-bsnz24jx	450	6	HSV-1	HSV-1	NNP
cord-280549-bsnz24jx	450	7	possesses	possess	VBZ
cord-280549-bsnz24jx	450	8	an	an	DT
cord-280549-bsnz24jx	450	9	ubiquitin	ubiquitin	JJ
cord-280549-bsnz24jx	450	10	E3	e3	NN
cord-280549-bsnz24jx	450	11	ligase	ligase	NN
cord-280549-bsnz24jx	450	12	activity	activity	NN
cord-280549-bsnz24jx	450	13	(	(	-LRB-
cord-280549-bsnz24jx	450	14	Boutell	Boutell	NNP
cord-280549-bsnz24jx	450	15	et	et	FW
cord-280549-bsnz24jx	450	16	al	al	NNP
cord-280549-bsnz24jx	450	17	.	.	NNP
cord-280549-bsnz24jx	450	18	,	,	,
cord-280549-bsnz24jx	450	19	2002	2002	CD
cord-280549-bsnz24jx	450	20	;	;	:
cord-280549-bsnz24jx	450	21	Hagglund	Hagglund	NNP
cord-280549-bsnz24jx	450	22	et	et	FW
cord-280549-bsnz24jx	450	23	al	al	NNP
cord-280549-bsnz24jx	450	24	.	.	NNP
cord-280549-bsnz24jx	450	25	,	,	,
cord-280549-bsnz24jx	450	26	2002	2002	CD
cord-280549-bsnz24jx	450	27	)	)	-RRB-
cord-280549-bsnz24jx	450	28	,	,	,
cord-280549-bsnz24jx	450	29	which	which	WDT
cord-280549-bsnz24jx	450	30	results	result	VBZ
cord-280549-bsnz24jx	450	31	in	in	IN
cord-280549-bsnz24jx	450	32	rapid	rapid	JJ
cord-280549-bsnz24jx	450	33	loss	loss	NN
cord-280549-bsnz24jx	450	34	of	of	IN
cord-280549-bsnz24jx	450	35	the	the	DT
cord-280549-bsnz24jx	450	36	centromeric	centromeric	JJ
cord-280549-bsnz24jx	450	37	protein	protein	NN
cord-280549-bsnz24jx	450	38	CENP	CENP	NNP
cord-280549-bsnz24jx	450	39	-	-	HYPH
cord-280549-bsnz24jx	450	40	C	C	NNP
cord-280549-bsnz24jx	450	41	and	and	CC
cord-280549-bsnz24jx	450	42	CENP	CENP	NNP
cord-280549-bsnz24jx	450	43	-	-	HYPH
cord-280549-bsnz24jx	450	44	A	a	NN
cord-280549-bsnz24jx	450	45	in	in	IN
cord-280549-bsnz24jx	450	46	a	a	DT
cord-280549-bsnz24jx	450	47	proteasome	proteasome	NN
cord-280549-bsnz24jx	450	48	-	-	HYPH
cord-280549-bsnz24jx	450	49	dependent	dependent	JJ
cord-280549-bsnz24jx	450	50	manner	manner	NN
cord-280549-bsnz24jx	450	51	and	and	CC
cord-280549-bsnz24jx	450	52	mitotic	mitotic	JJ
cord-280549-bsnz24jx	450	53	block	block	NN
cord-280549-bsnz24jx	450	54	(	(	-LRB-
cord-280549-bsnz24jx	450	55	Everett	Everett	NNP
cord-280549-bsnz24jx	450	56	et	et	NNP
cord-280549-bsnz24jx	450	57	al	al	NNP
cord-280549-bsnz24jx	450	58	.	.	.
cord-280549-bsnz24jx	451	1	,	,	,
cord-280549-bsnz24jx	451	2	1999	1999	CD
cord-280549-bsnz24jx	451	3	;	;	:
cord-280549-bsnz24jx	451	4	Lomonte	Lomonte	NNP
cord-280549-bsnz24jx	451	5	et	et	FW
cord-280549-bsnz24jx	451	6	al	al	NNP
cord-280549-bsnz24jx	451	7	.	.	NNP
cord-280549-bsnz24jx	451	8	,	,	,
cord-280549-bsnz24jx	451	9	2001	2001	CD
cord-280549-bsnz24jx	451	10	)	)	-RRB-
cord-280549-bsnz24jx	451	11	.	.	.
cord-280549-bsnz24jx	452	1	However	however	RB
cord-280549-bsnz24jx	452	2	,	,	,
cord-280549-bsnz24jx	452	3	it	-PRON-	PRP
cord-280549-bsnz24jx	452	4	remains	remain	VBZ
cord-280549-bsnz24jx	452	5	unclear	unclear	JJ
cord-280549-bsnz24jx	452	6	whether	whether	IN
cord-280549-bsnz24jx	452	7	these	these	DT
cord-280549-bsnz24jx	452	8	two	two	CD
cord-280549-bsnz24jx	452	9	centromere	centromere	NN
cord-280549-bsnz24jx	452	10	components	component	NNS
cord-280549-bsnz24jx	452	11	are	be	VBP
cord-280549-bsnz24jx	452	12	direct	direct	JJ
cord-280549-bsnz24jx	452	13	substrates	substrate	NNS
cord-280549-bsnz24jx	452	14	of	of	IN
cord-280549-bsnz24jx	452	15	the	the	DT
cord-280549-bsnz24jx	452	16	ICP0	ICP0	NNP
cord-280549-bsnz24jx	452	17	E3	E3	NNP
cord-280549-bsnz24jx	452	18	ligase	ligase	NN
cord-280549-bsnz24jx	452	19	(	(	-LRB-
cord-280549-bsnz24jx	452	20	dashed	dash	VBN
cord-280549-bsnz24jx	452	21	line	line	NN
cord-280549-bsnz24jx	452	22	)	)	-RRB-
cord-280549-bsnz24jx	452	23	.	.	.
cord-280549-bsnz24jx	453	1	Likewise	likewise	RB
cord-280549-bsnz24jx	453	2	,	,	,
cord-280549-bsnz24jx	453	3	ICP0	ICP0	NNP
cord-280549-bsnz24jx	453	4	can	can	MD
cord-280549-bsnz24jx	453	5	directly	directly	RB
cord-280549-bsnz24jx	453	6	ubiquitinate	ubiquitinate	JJ
cord-280549-bsnz24jx	453	7	p53	p53	NN
cord-280549-bsnz24jx	453	8	(	(	-LRB-
cord-280549-bsnz24jx	453	9	Boutell	Boutell	NNP
cord-280549-bsnz24jx	453	10	and	and	CC
cord-280549-bsnz24jx	453	11	Everett	Everett	NNP
cord-280549-bsnz24jx	453	12	,	,	,
cord-280549-bsnz24jx	453	13	2003	2003	CD
cord-280549-bsnz24jx	453	14	)	)	-RRB-
cord-280549-bsnz24jx	453	15	,	,	,
cord-280549-bsnz24jx	453	16	although	although	IN
cord-280549-bsnz24jx	453	17	p53	p53	NN
cord-280549-bsnz24jx	453	18	levels	level	NNS
cord-280549-bsnz24jx	453	19	are	be	VBP
cord-280549-bsnz24jx	453	20	not	not	RB
cord-280549-bsnz24jx	453	21	reduced	reduce	VBN
cord-280549-bsnz24jx	453	22	during	during	IN
cord-280549-bsnz24jx	453	23	HSV-1	HSV-1	NNP
cord-280549-bsnz24jx	453	24	infection	infection	NN
cord-280549-bsnz24jx	453	25	(	(	-LRB-
cord-280549-bsnz24jx	453	26	Hobbs	Hobbs	NNP
cord-280549-bsnz24jx	453	27	and	and	CC
cord-280549-bsnz24jx	453	28	DeLuca	DeLuca	NNP
cord-280549-bsnz24jx	453	29	,	,	,
cord-280549-bsnz24jx	453	30	1999	1999	CD
cord-280549-bsnz24jx	453	31	)	)	-RRB-
cord-280549-bsnz24jx	453	32	and	and	CC
cord-280549-bsnz24jx	453	33	,	,	,
cord-280549-bsnz24jx	453	34	hence	hence	RB
cord-280549-bsnz24jx	453	35	,	,	,
cord-280549-bsnz24jx	453	36	the	the	DT
cord-280549-bsnz24jx	453	37	role	role	NN
cord-280549-bsnz24jx	453	38	of	of	IN
cord-280549-bsnz24jx	453	39	p53	p53	NN
cord-280549-bsnz24jx	453	40	in	in	IN
cord-280549-bsnz24jx	453	41	ICP0-induced	icp0-induce	VBN
cord-280549-bsnz24jx	453	42	perturbation	perturbation	NN
cord-280549-bsnz24jx	453	43	of	of	IN
cord-280549-bsnz24jx	453	44	cell	cell	NN
cord-280549-bsnz24jx	453	45	cycle	cycle	NN
cord-280549-bsnz24jx	453	46	progression	progression	NN
cord-280549-bsnz24jx	453	47	remains	remain	VBZ
cord-280549-bsnz24jx	453	48	unclear	unclear	JJ
cord-280549-bsnz24jx	453	49	(	(	-LRB-
cord-280549-bsnz24jx	453	50	dashed	dash	VBN
cord-280549-bsnz24jx	453	51	line	line	NN
cord-280549-bsnz24jx	453	52	)	)	-RRB-
cord-280549-bsnz24jx	453	53	.	.	.
cord-280549-bsnz24jx	453	54	)	)	-RRB-
cord-280549-bsnz24jx	453	55	.	.	.
cord-280549-bsnz24jx	454	1	This	this	DT
cord-280549-bsnz24jx	454	2	suggests	suggest	VBZ
cord-280549-bsnz24jx	454	3	that	that	IN
cord-280549-bsnz24jx	454	4	HCMV	HCMV	NNP
cord-280549-bsnz24jx	454	5	possesses	possess	VBZ
cord-280549-bsnz24jx	454	6	mechanisms	mechanism	NNS
cord-280549-bsnz24jx	454	7	to	to	TO
cord-280549-bsnz24jx	454	8	regulate	regulate	VB
cord-280549-bsnz24jx	454	9	the	the	DT
cord-280549-bsnz24jx	454	10	subcellular	subcellular	JJ
cord-280549-bsnz24jx	454	11	distribution	distribution	NN
cord-280549-bsnz24jx	454	12	of	of	IN
cord-280549-bsnz24jx	454	13	CDK2	CDK2	NNP
cord-280549-bsnz24jx	454	14	,	,	,
cord-280549-bsnz24jx	454	15	thus	thus	RB
cord-280549-bsnz24jx	454	16	facilitating	facilitate	VBG
cord-280549-bsnz24jx	454	17	the	the	DT
cord-280549-bsnz24jx	454	18	activation	activation	NN
cord-280549-bsnz24jx	454	19	of	of	IN
cord-280549-bsnz24jx	454	20	cyclin	cyclin	NN
cord-280549-bsnz24jx	454	21	E	E	NNP
cord-280549-bsnz24jx	454	22	-	-	JJ
cord-280549-bsnz24jx	454	23	CDK2	cdk2	JJ
cord-280549-bsnz24jx	454	24	complex	complex	NN
cord-280549-bsnz24jx	454	25	and	and	CC
cord-280549-bsnz24jx	454	26	,	,	,
cord-280549-bsnz24jx	454	27	consequently	consequently	RB
cord-280549-bsnz24jx	454	28	,	,	,
cord-280549-bsnz24jx	454	29	modulating	modulate	VBG
cord-280549-bsnz24jx	454	30	cell	cell	NN
cord-280549-bsnz24jx	454	31	cycle	cycle	NN
cord-280549-bsnz24jx	454	32	progression	progression	NN
cord-280549-bsnz24jx	454	33	.	.	.
cord-280549-bsnz24jx	455	1	It	-PRON-	PRP
cord-280549-bsnz24jx	455	2	is	be	VBZ
cord-280549-bsnz24jx	455	3	possible	possible	JJ
cord-280549-bsnz24jx	455	4	that	that	IN
cord-280549-bsnz24jx	455	5	CDK2	CDK2	NNP
cord-280549-bsnz24jx	455	6	could	could	MD
cord-280549-bsnz24jx	455	7	be	be	VB
cord-280549-bsnz24jx	455	8	transported	transport	VBN
cord-280549-bsnz24jx	455	9	into	into	IN
cord-280549-bsnz24jx	455	10	the	the	DT
cord-280549-bsnz24jx	455	11	nucleus	nucleus	NN
cord-280549-bsnz24jx	455	12	in	in	IN
cord-280549-bsnz24jx	455	13	a	a	DT
cord-280549-bsnz24jx	455	14	"	"	``
cord-280549-bsnz24jx	455	15	piggyback	piggyback	NN
cord-280549-bsnz24jx	455	16	"	"	''
cord-280549-bsnz24jx	455	17	manner	manner	NN
cord-280549-bsnz24jx	455	18	,	,	,
cord-280549-bsnz24jx	455	19	interacting	interact	VBG
cord-280549-bsnz24jx	455	20	with	with	IN
cord-280549-bsnz24jx	455	21	a	a	DT
cord-280549-bsnz24jx	455	22	viral	viral	JJ
cord-280549-bsnz24jx	455	23	protein	protein	NN
cord-280549-bsnz24jx	455	24	that	that	WDT
cord-280549-bsnz24jx	455	25	shuttles	shuttle	NNS
cord-280549-bsnz24jx	455	26	between	between	IN
cord-280549-bsnz24jx	455	27	nucleus	nucleus	NN
cord-280549-bsnz24jx	455	28	and	and	CC
cord-280549-bsnz24jx	455	29	cytoplasm	cytoplasm	JJ
cord-280549-bsnz24jx	455	30	,	,	,
cord-280549-bsnz24jx	455	31	or	or	CC
cord-280549-bsnz24jx	455	32	that	that	IN
cord-280549-bsnz24jx	455	33	viral	viral	JJ
cord-280549-bsnz24jx	455	34	infection	infection	NN
cord-280549-bsnz24jx	455	35	activates	activate	VBZ
cord-280549-bsnz24jx	455	36	the	the	DT
cord-280549-bsnz24jx	455	37	intrinsic	intrinsic	JJ
cord-280549-bsnz24jx	455	38	CDK2	CDK2	NNP
cord-280549-bsnz24jx	455	39	import	import	NN
cord-280549-bsnz24jx	455	40	machinery	machinery	NN
cord-280549-bsnz24jx	455	41	.	.	.
cord-280549-bsnz24jx	456	1	Indeed	indeed	RB
cord-280549-bsnz24jx	456	2	,	,	,
cord-280549-bsnz24jx	456	3	infection	infection	NN
cord-280549-bsnz24jx	456	4	of	of	IN
cord-280549-bsnz24jx	456	5	primary	primary	JJ
cord-280549-bsnz24jx	456	6	erythroid	erythroid	NN
cord-280549-bsnz24jx	456	7	progenitor	progenitor	NN
cord-280549-bsnz24jx	456	8	cells	cell	NNS
cord-280549-bsnz24jx	456	9	by	by	IN
cord-280549-bsnz24jx	456	10	human	human	JJ
cord-280549-bsnz24jx	456	11	parvovirus	parvovirus	NN
cord-280549-bsnz24jx	456	12	B19	B19	NNP
cord-280549-bsnz24jx	456	13	(	(	-LRB-
cord-280549-bsnz24jx	456	14	B19V	b19v	NN
cord-280549-bsnz24jx	456	15	)	)	-RRB-
cord-280549-bsnz24jx	456	16	leads	lead	VBZ
cord-280549-bsnz24jx	456	17	to	to	IN
cord-280549-bsnz24jx	456	18	G2	G2	NNP
cord-280549-bsnz24jx	456	19	arrest	arrest	NN
cord-280549-bsnz24jx	456	20	,	,	,
cord-280549-bsnz24jx	456	21	which	which	WDT
cord-280549-bsnz24jx	456	22	is	be	VBZ
cord-280549-bsnz24jx	456	23	dependent	dependent	JJ
cord-280549-bsnz24jx	456	24	on	on	IN
cord-280549-bsnz24jx	456	25	viral	viral	JJ
cord-280549-bsnz24jx	456	26	nonstructural	nonstructural	JJ
cord-280549-bsnz24jx	456	27	protein	protein	NN
cord-280549-bsnz24jx	456	28	1	1	CD
cord-280549-bsnz24jx	456	29	(	(	-LRB-
cord-280549-bsnz24jx	456	30	NS1	ns1	CD
cord-280549-bsnz24jx	456	31	)	)	-RRB-
cord-280549-bsnz24jx	456	32	,	,	,
cord-280549-bsnz24jx	456	33	as	as	IN
cord-280549-bsnz24jx	456	34	its	-PRON-	PRP$
cord-280549-bsnz24jx	456	35	sole	sole	JJ
cord-280549-bsnz24jx	456	36	expression	expression	NN
cord-280549-bsnz24jx	456	37	could	could	MD
cord-280549-bsnz24jx	456	38	recapitulate	recapitulate	VB
cord-280549-bsnz24jx	456	39	the	the	DT
cord-280549-bsnz24jx	456	40	same	same	JJ
cord-280549-bsnz24jx	456	41	phenomenon	phenomenon	NN
cord-280549-bsnz24jx	456	42	(	(	-LRB-
cord-280549-bsnz24jx	456	43	Wan	Wan	NNP
cord-280549-bsnz24jx	456	44	et	et	NNP
cord-280549-bsnz24jx	456	45	al	al	NNP
cord-280549-bsnz24jx	456	46	.	.	NNP
cord-280549-bsnz24jx	456	47	,	,	,
cord-280549-bsnz24jx	456	48	2010	2010	CD
cord-280549-bsnz24jx	456	49	)	)	-RRB-
cord-280549-bsnz24jx	456	50	.	.	.
cord-280549-bsnz24jx	457	1	The	the	DT
cord-280549-bsnz24jx	457	2	cell	cell	NN
cord-280549-bsnz24jx	457	3	cycle	cycle	NN
cord-280549-bsnz24jx	457	4	perturbation	perturbation	NN
cord-280549-bsnz24jx	457	5	effect	effect	NN
cord-280549-bsnz24jx	457	6	results	result	NNS
cord-280549-bsnz24jx	457	7	from	from	IN
cord-280549-bsnz24jx	457	8	NS1-mediated	ns1-mediated	JJ
cord-280549-bsnz24jx	457	9	downregulation	downregulation	NN
cord-280549-bsnz24jx	457	10	of	of	IN
cord-280549-bsnz24jx	457	11	activating	activate	VBG
cord-280549-bsnz24jx	457	12	E2Fs	e2fs	CD
cord-280549-bsnz24jx	457	13	transcription	transcription	NN
cord-280549-bsnz24jx	457	14	factors	factor	NNS
cord-280549-bsnz24jx	457	15	(	(	-LRB-
cord-280549-bsnz24jx	457	16	E2F1	E2F1	NNP
cord-280549-bsnz24jx	457	17	to	to	IN
cord-280549-bsnz24jx	457	18	E2F3a	E2F3a	NNP
cord-280549-bsnz24jx	457	19	)	)	-RRB-
cord-280549-bsnz24jx	457	20	and	and	CC
cord-280549-bsnz24jx	457	21	upregulation	upregulation	NN
cord-280549-bsnz24jx	457	22	of	of	IN
cord-280549-bsnz24jx	457	23	repressive	repressive	JJ
cord-280549-bsnz24jx	457	24	E2Fs	E2Fs	NNP
cord-280549-bsnz24jx	457	25	(	(	-LRB-
cord-280549-bsnz24jx	457	26	E2F4	E2F4	NNP
cord-280549-bsnz24jx	457	27	to	to	IN
cord-280549-bsnz24jx	457	28	E2F8	E2F8	NNP
cord-280549-bsnz24jx	457	29	)	)	-RRB-
cord-280549-bsnz24jx	457	30	.	.	.
cord-280549-bsnz24jx	458	1	Interestingly	interestingly	RB
cord-280549-bsnz24jx	458	2	,	,	,
cord-280549-bsnz24jx	458	3	co	co	JJ
cord-280549-bsnz24jx	458	4	-	-	JJ
cord-280549-bsnz24jx	458	5	immunoprecipitation	immunoprecipitation	JJ
cord-280549-bsnz24jx	458	6	experiments	experiment	NNS
cord-280549-bsnz24jx	458	7	in	in	IN
cord-280549-bsnz24jx	458	8	NS1	NS1	NNS
cord-280549-bsnz24jx	458	9	expressing	express	VBG
cord-280549-bsnz24jx	458	10	cells	cell	NNS
cord-280549-bsnz24jx	458	11	identified	identify	VBD
cord-280549-bsnz24jx	458	12	NS1-E2F4	NS1-E2F4	NNP
cord-280549-bsnz24jx	458	13	and	and	CC
cord-280549-bsnz24jx	458	14	NS1-E2F5	NS1-E2F5	NNP
cord-280549-bsnz24jx	458	15	complexes	complex	NNS
cord-280549-bsnz24jx	458	16	,	,	,
cord-280549-bsnz24jx	458	17	which	which	WDT
cord-280549-bsnz24jx	458	18	could	could	MD
cord-280549-bsnz24jx	458	19	enhance	enhance	VB
cord-280549-bsnz24jx	458	20	the	the	DT
cord-280549-bsnz24jx	458	21	nuclear	nuclear	JJ
cord-280549-bsnz24jx	458	22	import	import	NN
cord-280549-bsnz24jx	458	23	of	of	IN
cord-280549-bsnz24jx	458	24	these	these	DT
cord-280549-bsnz24jx	458	25	transcription	transcription	NN
cord-280549-bsnz24jx	458	26	-	-	HYPH
cord-280549-bsnz24jx	458	27	repressive	repressive	JJ
cord-280549-bsnz24jx	458	28	factors	factor	NNS
cord-280549-bsnz24jx	458	29	.	.	.
cord-280549-bsnz24jx	459	1	Normal	normal	JJ
cord-280549-bsnz24jx	459	2	cell	cell	NN
cord-280549-bsnz24jx	459	3	cycle	cycle	NN
cord-280549-bsnz24jx	459	4	progression	progression	NN
cord-280549-bsnz24jx	459	5	was	be	VBD
cord-280549-bsnz24jx	459	6	observed	observe	VBN
cord-280549-bsnz24jx	459	7	in	in	IN
cord-280549-bsnz24jx	459	8	cells	cell	NNS
cord-280549-bsnz24jx	459	9	infected	infect	VBN
cord-280549-bsnz24jx	459	10	with	with	IN
cord-280549-bsnz24jx	459	11	a	a	DT
cord-280549-bsnz24jx	459	12	mutant	mutant	NN
cord-280549-bsnz24jx	459	13	B19V	b19v	NN
cord-280549-bsnz24jx	459	14	,	,	,
cord-280549-bsnz24jx	459	15	which	which	WDT
cord-280549-bsnz24jx	459	16	encodes	encode	VBZ
cord-280549-bsnz24jx	459	17	a	a	DT
cord-280549-bsnz24jx	459	18	nuclearlocalization	nuclearlocalization	NN
cord-280549-bsnz24jx	459	19	-	-	HYPH
cord-280549-bsnz24jx	459	20	deficient	deficient	JJ
cord-280549-bsnz24jx	459	21	NS1	ns1	NN
cord-280549-bsnz24jx	459	22	,	,	,
cord-280549-bsnz24jx	459	23	demonstrating	demonstrate	VBG
cord-280549-bsnz24jx	459	24	the	the	DT
cord-280549-bsnz24jx	459	25	importance	importance	NN
cord-280549-bsnz24jx	459	26	of	of	IN
cord-280549-bsnz24jx	459	27	NS1-mediated	ns1-mediated	JJ
cord-280549-bsnz24jx	459	28	redistribution	redistribution	NN
cord-280549-bsnz24jx	459	29	of	of	IN
cord-280549-bsnz24jx	459	30	E2F4	E2F4	NNP
cord-280549-bsnz24jx	459	31	and	and	CC
cord-280549-bsnz24jx	459	32	E2F5	E2F5	NNP
cord-280549-bsnz24jx	459	33	in	in	IN
cord-280549-bsnz24jx	459	34	causing	cause	VBG
cord-280549-bsnz24jx	459	35	cell	cell	NN
cord-280549-bsnz24jx	459	36	cycle	cycle	NN
cord-280549-bsnz24jx	459	37	perturbation	perturbation	NN
cord-280549-bsnz24jx	459	38	(	(	-LRB-
cord-280549-bsnz24jx	459	39	Wan	Wan	NNP
cord-280549-bsnz24jx	459	40	et	et	NNP
cord-280549-bsnz24jx	459	41	al	al	NNP
cord-280549-bsnz24jx	459	42	.	.	NNP
cord-280549-bsnz24jx	459	43	,	,	,
cord-280549-bsnz24jx	459	44	2010	2010	CD
cord-280549-bsnz24jx	459	45	)	)	-RRB-
cord-280549-bsnz24jx	459	46	.	.	.
cord-280549-bsnz24jx	460	1	For	for	IN
cord-280549-bsnz24jx	460	2	cyclin	cyclin	NN
cord-280549-bsnz24jx	460	3	D3	D3	NNP
cord-280549-bsnz24jx	460	4	to	to	TO
cord-280549-bsnz24jx	460	5	exert	exert	VB
cord-280549-bsnz24jx	460	6	its	-PRON-	PRP$
cord-280549-bsnz24jx	460	7	effect	effect	NN
cord-280549-bsnz24jx	460	8	in	in	IN
cord-280549-bsnz24jx	460	9	cell	cell	NN
cord-280549-bsnz24jx	460	10	cycle	cycle	NN
cord-280549-bsnz24jx	460	11	G0	G0	NNP
cord-280549-bsnz24jx	460	12	/	/	SYM
cord-280549-bsnz24jx	460	13	G1	G1	NNP
cord-280549-bsnz24jx	460	14	progression	progression	NN
cord-280549-bsnz24jx	460	15	,	,	,
cord-280549-bsnz24jx	460	16	it	-PRON-	PRP
cord-280549-bsnz24jx	460	17	needs	need	VBZ
cord-280549-bsnz24jx	460	18	to	to	TO
cord-280549-bsnz24jx	460	19	be	be	VB
cord-280549-bsnz24jx	460	20	transported	transport	VBN
cord-280549-bsnz24jx	460	21	from	from	IN
cord-280549-bsnz24jx	460	22	the	the	DT
cord-280549-bsnz24jx	460	23	cytoplasm	cytoplasm	NN
cord-280549-bsnz24jx	460	24	to	to	IN
cord-280549-bsnz24jx	460	25	the	the	DT
cord-280549-bsnz24jx	460	26	nucleus	nucleus	NN
cord-280549-bsnz24jx	460	27	(	(	-LRB-
cord-280549-bsnz24jx	461	1	Mahony	Mahony	NNP
cord-280549-bsnz24jx	461	2	et	et	NNP
cord-280549-bsnz24jx	461	3	al	al	NNP
cord-280549-bsnz24jx	461	4	.	.	NNP
cord-280549-bsnz24jx	461	5	,	,	,
cord-280549-bsnz24jx	461	6	1998	1998	CD
cord-280549-bsnz24jx	461	7	)	)	-RRB-
cord-280549-bsnz24jx	461	8	.	.	.
cord-280549-bsnz24jx	462	1	It	-PRON-	PRP
cord-280549-bsnz24jx	462	2	was	be	VBD
cord-280549-bsnz24jx	462	3	demonstrated	demonstrate	VBN
cord-280549-bsnz24jx	462	4	through	through	IN
cord-280549-bsnz24jx	462	5	confocoal	confocoal	NN
cord-280549-bsnz24jx	462	6	imaging	imaging	NN
cord-280549-bsnz24jx	462	7	and	and	CC
cord-280549-bsnz24jx	462	8	subcellular	subcellular	JJ
cord-280549-bsnz24jx	462	9	fractionation	fractionation	NN
cord-280549-bsnz24jx	462	10	assay	assay	NN
cord-280549-bsnz24jx	462	11	that	that	WDT
cord-280549-bsnz24jx	462	12	,	,	,
cord-280549-bsnz24jx	462	13	in	in	IN
cord-280549-bsnz24jx	462	14	influenza	influenza	NN
cord-280549-bsnz24jx	462	15	A	a	DT
cord-280549-bsnz24jx	462	16	virus	virus	NN
cord-280549-bsnz24jx	462	17	infected	infect	VBN
cord-280549-bsnz24jx	462	18	cells	cell	NNS
cord-280549-bsnz24jx	462	19	,	,	,
cord-280549-bsnz24jx	462	20	cyclin	cyclin	NN
cord-280549-bsnz24jx	462	21	D3	D3	NNP
cord-280549-bsnz24jx	462	22	was	be	VBD
cord-280549-bsnz24jx	462	23	significantly	significantly	RB
cord-280549-bsnz24jx	462	24	Reduced	reduce	VBN
cord-280549-bsnz24jx	462	25	nuclear	nuclear	JJ
cord-280549-bsnz24jx	462	26	translocation	translocation	NN
cord-280549-bsnz24jx	462	27	,	,	,
cord-280549-bsnz24jx	462	28	ant	ant	JJ
cord-280549-bsnz24jx	462	29	-	-	HYPH
cord-280549-bsnz24jx	462	30	apoptotic	apoptotic	JJ
cord-280549-bsnz24jx	462	31	Kovacs	Kovacs	NNP
cord-280549-bsnz24jx	462	32	et	et	NNP
cord-280549-bsnz24jx	462	33	al	al	NNP
cord-280549-bsnz24jx	462	34	.	.	NNP
cord-280549-bsnz24jx	462	35	,	,	,
cord-280549-bsnz24jx	462	36	1996	1996	CD
cord-280549-bsnz24jx	462	37	;	;	:
cord-280549-bsnz24jx	462	38	Fortunato	Fortunato	NNP
cord-280549-bsnz24jx	462	39	and	and	CC
cord-280549-bsnz24jx	462	40	Spector	Spector	NNP
cord-280549-bsnz24jx	462	41	,	,	,
cord-280549-bsnz24jx	462	42	1998	1998	CD
cord-280549-bsnz24jx	462	43	;	;	:
cord-280549-bsnz24jx	462	44	Majumder	Majumder	NNP
cord-280549-bsnz24jx	462	45	et	et	NNP
cord-280549-bsnz24jx	462	46	al	al	NNP
cord-280549-bsnz24jx	462	47	.	.	NNP
cord-280549-bsnz24jx	462	48	,	,	,
cord-280549-bsnz24jx	462	49	2001	2001	CD
cord-280549-bsnz24jx	462	50	Parvovirus	Parvovirus	NNP
cord-280549-bsnz24jx	462	51	B19	B19	NNP
cord-280549-bsnz24jx	462	52	/	/	,
cord-280549-bsnz24jx	462	53	ssDNA	ssdna	NN
cord-280549-bsnz24jx	462	54	NS1	ns1	UH
cord-280549-bsnz24jx	462	55	E2F4	E2F4	NNP
cord-280549-bsnz24jx	462	56	-	-	HYPH
cord-280549-bsnz24jx	462	57	8	8	CD
cord-280549-bsnz24jx	462	58	repressive	repressive	JJ
cord-280549-bsnz24jx	462	59	transcription	transcription	NN
cord-280549-bsnz24jx	462	60	factors	factor	NNS
cord-280549-bsnz24jx	462	61	Nuclear	nuclear	JJ
cord-280549-bsnz24jx	462	62	import	import	NN
cord-280549-bsnz24jx	462	63	and	and	CC
cord-280549-bsnz24jx	462	64	G2	G2	NNP
cord-280549-bsnz24jx	462	65	arrest	arrest	NN
cord-280549-bsnz24jx	462	66	Wan	Wan	NNP
cord-280549-bsnz24jx	462	67	et	et	NNP
cord-280549-bsnz24jx	462	68	al	al	NNP
cord-280549-bsnz24jx	462	69	.	.	NNP
cord-280549-bsnz24jx	462	70	,	,	,
cord-280549-bsnz24jx	462	71	2010	2010	CD
cord-280549-bsnz24jx	463	1	Epstein	Epstein	NNP
cord-280549-bsnz24jx	463	2	-	-	HYPH
cord-280549-bsnz24jx	463	3	Barr	Barr	NNP
cord-280549-bsnz24jx	463	4	/	/	SYM
cord-280549-bsnz24jx	463	5	dsDNA	dsdna	RB
cord-280549-bsnz24jx	463	6	LMP1	LMP1	NNP
cord-280549-bsnz24jx	463	7	Survivin	Survivin	NNP
cord-280549-bsnz24jx	463	8	,	,	,
cord-280549-bsnz24jx	463	9	p53	p53	NN
cord-280549-bsnz24jx	463	10	Increased	increase	VBN
cord-280549-bsnz24jx	464	1	nuclear	nuclear	JJ
cord-280549-bsnz24jx	464	2	localization	localization	NN
cord-280549-bsnz24jx	464	3	Guo	Guo	NNP
cord-280549-bsnz24jx	464	4	et	et	FW
cord-280549-bsnz24jx	464	5	al	al	NNP
cord-280549-bsnz24jx	464	6	.	.	.
cord-280549-bsnz24jx	465	1	,	,	,
cord-280549-bsnz24jx	466	1	2012	2012	CD
cord-280549-bsnz24jx	467	1	Avian	Avian	NNP
cord-280549-bsnz24jx	467	2	Reovirus	Reovirus	NNP
cord-280549-bsnz24jx	467	3	/	/	SYM
cord-280549-bsnz24jx	467	4	dsRNA	dsrna	NN
cord-280549-bsnz24jx	468	1	P17	P17	NNP
cord-280549-bsnz24jx	468	2	CDK1	CDK1	NNP
cord-280549-bsnz24jx	468	3	Cytoplasmic	Cytoplasmic	NNP
cord-280549-bsnz24jx	468	4	retention	retention	NN
cord-280549-bsnz24jx	468	5	Chiu	Chiu	NNP
cord-280549-bsnz24jx	468	6	et	et	NNP
cord-280549-bsnz24jx	468	7	al	al	NNP
cord-280549-bsnz24jx	468	8	.	.	NNP
cord-280549-bsnz24jx	468	9	,	,	,
cord-280549-bsnz24jx	468	10	2018	2018	CD
cord-280549-bsnz24jx	468	11	redistributed	redistribute	VBD
cord-280549-bsnz24jx	468	12	from	from	IN
cord-280549-bsnz24jx	468	13	the	the	DT
cord-280549-bsnz24jx	468	14	nucleus	nucleus	NN
cord-280549-bsnz24jx	468	15	to	to	IN
cord-280549-bsnz24jx	468	16	the	the	DT
cord-280549-bsnz24jx	468	17	cytoplasm	cytoplasm	NN
cord-280549-bsnz24jx	468	18	,	,	,
cord-280549-bsnz24jx	468	19	followed	follow	VBN
cord-280549-bsnz24jx	468	20	by	by	IN
cord-280549-bsnz24jx	468	21	its	-PRON-	PRP$
cord-280549-bsnz24jx	468	22	proteasomal	proteasomal	JJ
cord-280549-bsnz24jx	468	23	degradation	degradation	NN
cord-280549-bsnz24jx	468	24	(	(	-LRB-
cord-280549-bsnz24jx	468	25	Fan	fan	NN
cord-280549-bsnz24jx	468	26	et	et	NNP
cord-280549-bsnz24jx	468	27	al	al	NNP
cord-280549-bsnz24jx	468	28	.	.	NNP
cord-280549-bsnz24jx	468	29	,	,	,
cord-280549-bsnz24jx	468	30	2017	2017	CD
cord-280549-bsnz24jx	468	31	)	)	-RRB-
cord-280549-bsnz24jx	468	32	.	.	.
cord-280549-bsnz24jx	469	1	Hence	hence	RB
cord-280549-bsnz24jx	469	2	,	,	,
cord-280549-bsnz24jx	469	3	through	through	IN
cord-280549-bsnz24jx	469	4	multiple	multiple	JJ
cord-280549-bsnz24jx	469	5	mechanisms	mechanism	NNS
cord-280549-bsnz24jx	469	6	,	,	,
cord-280549-bsnz24jx	469	7	influenza	influenza	NN
cord-280549-bsnz24jx	469	8	A	a	DT
cord-280549-bsnz24jx	469	9	virus	virus	NN
cord-280549-bsnz24jx	469	10	perturbs	perturb	VBZ
cord-280549-bsnz24jx	469	11	cell	cell	NN
cord-280549-bsnz24jx	469	12	cycle	cycle	NN
cord-280549-bsnz24jx	469	13	progression	progression	NN
cord-280549-bsnz24jx	469	14	for	for	IN
cord-280549-bsnz24jx	469	15	enhanced	enhanced	JJ
cord-280549-bsnz24jx	469	16	progeny	progeny	JJ
cord-280549-bsnz24jx	469	17	virus	virus	NN
cord-280549-bsnz24jx	469	18	production	production	NN
cord-280549-bsnz24jx	469	19	.	.	.
cord-280549-bsnz24jx	470	1	Similarly	similarly	RB
cord-280549-bsnz24jx	470	2	,	,	,
cord-280549-bsnz24jx	470	3	a	a	DT
cord-280549-bsnz24jx	470	4	significant	significant	JJ
cord-280549-bsnz24jx	470	5	increase	increase	NN
cord-280549-bsnz24jx	470	6	in	in	IN
cord-280549-bsnz24jx	470	7	the	the	DT
cord-280549-bsnz24jx	470	8	cytoplasmic	cytoplasmic	JJ
cord-280549-bsnz24jx	470	9	level	level	NN
cord-280549-bsnz24jx	470	10	of	of	IN
cord-280549-bsnz24jx	470	11	CDK1	CDK1	NNP
cord-280549-bsnz24jx	470	12	was	be	VBD
cord-280549-bsnz24jx	470	13	observed	observe	VBN
cord-280549-bsnz24jx	470	14	in	in	IN
cord-280549-bsnz24jx	470	15	ARV	ARV	NNP
cord-280549-bsnz24jx	470	16	-	-	HYPH
cord-280549-bsnz24jx	470	17	infected	infect	VBN
cord-280549-bsnz24jx	470	18	or	or	CC
cord-280549-bsnz24jx	470	19	p17-expressing	p17-expressing	NN
cord-280549-bsnz24jx	470	20	cells	cell	NNS
cord-280549-bsnz24jx	470	21	(	(	-LRB-
cord-280549-bsnz24jx	470	22	Chiu	Chiu	NNP
cord-280549-bsnz24jx	470	23	et	et	NNP
cord-280549-bsnz24jx	470	24	al	al	NNP
cord-280549-bsnz24jx	470	25	.	.	NNP
cord-280549-bsnz24jx	470	26	,	,	,
cord-280549-bsnz24jx	470	27	2018	2018	CD
cord-280549-bsnz24jx	470	28	)	)	-RRB-
cord-280549-bsnz24jx	470	29	.	.	.
cord-280549-bsnz24jx	471	1	Thus	thus	RB
cord-280549-bsnz24jx	471	2	,	,	,
cord-280549-bsnz24jx	471	3	p17	p17	NN
cord-280549-bsnz24jx	471	4	of	of	IN
cord-280549-bsnz24jx	471	5	ARV	ARV	NNP
cord-280549-bsnz24jx	471	6	not	not	RB
cord-280549-bsnz24jx	471	7	only	only	RB
cord-280549-bsnz24jx	471	8	perturbs	perturb	VBZ
cord-280549-bsnz24jx	471	9	cell	cell	NN
cord-280549-bsnz24jx	471	10	cycle	cycle	NN
cord-280549-bsnz24jx	471	11	progression	progression	NN
cord-280549-bsnz24jx	471	12	into	into	IN
cord-280549-bsnz24jx	471	13	mitosis	mitosis	NN
cord-280549-bsnz24jx	471	14	through	through	IN
cord-280549-bsnz24jx	471	15	direct	direct	JJ
cord-280549-bsnz24jx	471	16	inhibition	inhibition	NN
cord-280549-bsnz24jx	471	17	of	of	IN
cord-280549-bsnz24jx	471	18	CDK1	CDK1	NNP
cord-280549-bsnz24jx	471	19	kinase	kinase	NN
cord-280549-bsnz24jx	471	20	activity	activity	NN
cord-280549-bsnz24jx	471	21	,	,	,
cord-280549-bsnz24jx	471	22	but	but	CC
cord-280549-bsnz24jx	471	23	also	also	RB
cord-280549-bsnz24jx	471	24	disrupts	disrupt	VBZ
cord-280549-bsnz24jx	471	25	CDK1	CDK1	NNP
cord-280549-bsnz24jx	471	26	/	/	SYM
cord-280549-bsnz24jx	471	27	cyclin	cyclin	NN
cord-280549-bsnz24jx	471	28	B1	b1	NN
cord-280549-bsnz24jx	471	29	complex	complex	JJ
cord-280549-bsnz24jx	471	30	formation	formation	NN
cord-280549-bsnz24jx	471	31	in	in	IN
cord-280549-bsnz24jx	471	32	the	the	DT
cord-280549-bsnz24jx	471	33	nucleus	nucleus	NN
cord-280549-bsnz24jx	471	34	by	by	IN
cord-280549-bsnz24jx	471	35	sequestering	sequester	VBG
cord-280549-bsnz24jx	471	36	CDK1	CDK1	NNP
cord-280549-bsnz24jx	471	37	in	in	IN
cord-280549-bsnz24jx	471	38	the	the	DT
cord-280549-bsnz24jx	471	39	cytoplasm	cytoplasm	NN
cord-280549-bsnz24jx	471	40	.	.	.
cord-280549-bsnz24jx	472	1	Although	although	IN
cord-280549-bsnz24jx	472	2	total	total	JJ
cord-280549-bsnz24jx	472	3	p53	p53	NN
cord-280549-bsnz24jx	472	4	levels	level	NNS
cord-280549-bsnz24jx	472	5	were	be	VBD
cord-280549-bsnz24jx	472	6	elevated	elevate	VBN
cord-280549-bsnz24jx	472	7	after	after	IN
cord-280549-bsnz24jx	472	8	infection	infection	NN
cord-280549-bsnz24jx	472	9	,	,	,
cord-280549-bsnz24jx	472	10	a	a	DT
cord-280549-bsnz24jx	472	11	reduction	reduction	NN
cord-280549-bsnz24jx	472	12	of	of	IN
cord-280549-bsnz24jx	472	13	p53	p53	NN
cord-280549-bsnz24jx	472	14	level	level	NN
cord-280549-bsnz24jx	472	15	in	in	IN
cord-280549-bsnz24jx	472	16	nuclear	nuclear	JJ
cord-280549-bsnz24jx	472	17	extracts	extract	NNS
cord-280549-bsnz24jx	472	18	of	of	IN
cord-280549-bsnz24jx	472	19	HCMV	HCMV	NNP
cord-280549-bsnz24jx	472	20	-	-	HYPH
cord-280549-bsnz24jx	472	21	infected	infect	VBN
cord-280549-bsnz24jx	472	22	human	human	JJ
cord-280549-bsnz24jx	472	23	umbilical	umbilical	JJ
cord-280549-bsnz24jx	472	24	vein	vein	NN
cord-280549-bsnz24jx	472	25	endothelial	endothelial	JJ
cord-280549-bsnz24jx	472	26	cells	cell	NNS
cord-280549-bsnz24jx	472	27	was	be	VBD
cord-280549-bsnz24jx	472	28	observed	observe	VBN
cord-280549-bsnz24jx	472	29	,	,	,
cord-280549-bsnz24jx	472	30	resulting	result	VBG
cord-280549-bsnz24jx	472	31	in	in	IN
cord-280549-bsnz24jx	472	32	an	an	DT
cord-280549-bsnz24jx	472	33	anti	anti	JJ
cord-280549-bsnz24jx	472	34	-	-	JJ
cord-280549-bsnz24jx	472	35	apoptotic	apoptotic	JJ
cord-280549-bsnz24jx	472	36	phenotype	phenotype	NN
cord-280549-bsnz24jx	472	37	of	of	IN
cord-280549-bsnz24jx	472	38	HCMV	HCMV	NNP
cord-280549-bsnz24jx	472	39	-	-	HYPH
cord-280549-bsnz24jx	472	40	infected	infect	VBN
cord-280549-bsnz24jx	472	41	cells	cell	NNS
cord-280549-bsnz24jx	472	42	(	(	-LRB-
cord-280549-bsnz24jx	472	43	Kovacs	Kovacs	NNP
cord-280549-bsnz24jx	472	44	et	et	NNP
cord-280549-bsnz24jx	472	45	al	al	NNP
cord-280549-bsnz24jx	472	46	.	.	NNP
cord-280549-bsnz24jx	472	47	,	,	,
cord-280549-bsnz24jx	472	48	1996	1996	CD
cord-280549-bsnz24jx	472	49	)	)	-RRB-
cord-280549-bsnz24jx	472	50	.	.	.
cord-280549-bsnz24jx	473	1	The	the	DT
cord-280549-bsnz24jx	473	2	reduced	reduce	VBN
cord-280549-bsnz24jx	473	3	nuclear	nuclear	NN
cord-280549-bsnz24jx	473	4	-	-	HYPH
cord-280549-bsnz24jx	473	5	translocation	translocation	NN
cord-280549-bsnz24jx	473	6	of	of	IN
cord-280549-bsnz24jx	473	7	p53	p53	NN
cord-280549-bsnz24jx	473	8	by	by	IN
cord-280549-bsnz24jx	473	9	HCMV	HCMV	NNP
cord-280549-bsnz24jx	473	10	,	,	,
cord-280549-bsnz24jx	473	11	as	as	IN
cord-280549-bsnz24jx	473	12	suggested	suggest	VBN
cord-280549-bsnz24jx	473	13	by	by	IN
cord-280549-bsnz24jx	473	14	immunofluoresence	immunofluoresence	NNP
cord-280549-bsnz24jx	473	15	,	,	,
cord-280549-bsnz24jx	473	16	provides	provide	VBZ
cord-280549-bsnz24jx	473	17	a	a	DT
cord-280549-bsnz24jx	473	18	plausible	plausible	JJ
cord-280549-bsnz24jx	473	19	explanation	explanation	NN
cord-280549-bsnz24jx	473	20	for	for	IN
cord-280549-bsnz24jx	473	21	the	the	DT
cord-280549-bsnz24jx	473	22	oncogenic	oncogenic	JJ
cord-280549-bsnz24jx	473	23	potential	potential	NN
cord-280549-bsnz24jx	473	24	of	of	IN
cord-280549-bsnz24jx	473	25	HCMV	HCMV	NNP
cord-280549-bsnz24jx	473	26	(	(	-LRB-
cord-280549-bsnz24jx	473	27	Kovacs	Kovacs	NNP
cord-280549-bsnz24jx	473	28	et	et	NNP
cord-280549-bsnz24jx	473	29	al	al	NNP
cord-280549-bsnz24jx	473	30	.	.	NNP
cord-280549-bsnz24jx	473	31	,	,	,
cord-280549-bsnz24jx	473	32	1996	1996	CD
cord-280549-bsnz24jx	473	33	)	)	-RRB-
cord-280549-bsnz24jx	473	34	.	.	.
cord-280549-bsnz24jx	474	1	Wang	Wang	NNP
cord-280549-bsnz24jx	474	2	et	et	NNP
cord-280549-bsnz24jx	474	3	al	al	NNP
cord-280549-bsnz24jx	474	4	.	.	.
cord-280549-bsnz24jx	475	1	later	later	RB
cord-280549-bsnz24jx	475	2	reported	report	VBD
cord-280549-bsnz24jx	475	3	that	that	IN
cord-280549-bsnz24jx	475	4	the	the	DT
cord-280549-bsnz24jx	475	5	cytoplasmic	cytoplasmic	JJ
cord-280549-bsnz24jx	475	6	sequestration	sequestration	NN
cord-280549-bsnz24jx	475	7	of	of	IN
cord-280549-bsnz24jx	475	8	p53	p53	NN
cord-280549-bsnz24jx	475	9	by	by	IN
cord-280549-bsnz24jx	475	10	HCMV	HCMV	NNP
cord-280549-bsnz24jx	475	11	occurs	occur	VBZ
cord-280549-bsnz24jx	475	12	by	by	IN
cord-280549-bsnz24jx	475	13	blocking	block	VBG
cord-280549-bsnz24jx	475	14	the	the	DT
cord-280549-bsnz24jx	475	15	nuclear	nuclear	JJ
cord-280549-bsnz24jx	475	16	localization	localization	NN
cord-280549-bsnz24jx	475	17	signal	signal	NN
cord-280549-bsnz24jx	475	18	(	(	-LRB-
cord-280549-bsnz24jx	475	19	NLS	NLS	NNP
cord-280549-bsnz24jx	475	20	)	)	-RRB-
cord-280549-bsnz24jx	475	21	of	of	IN
cord-280549-bsnz24jx	475	22	p53	p53	NN
cord-280549-bsnz24jx	475	23	(	(	-LRB-
cord-280549-bsnz24jx	475	24	Wang	Wang	NNP
cord-280549-bsnz24jx	475	25	et	et	NNP
cord-280549-bsnz24jx	475	26	al	al	NNP
cord-280549-bsnz24jx	475	27	.	.	NNP
cord-280549-bsnz24jx	475	28	,	,	,
cord-280549-bsnz24jx	475	29	2001	2001	CD
cord-280549-bsnz24jx	475	30	)	)	-RRB-
cord-280549-bsnz24jx	475	31	.	.	.
cord-280549-bsnz24jx	476	1	Interestingly	interestingly	RB
cord-280549-bsnz24jx	476	2	,	,	,
cord-280549-bsnz24jx	476	3	in	in	IN
cord-280549-bsnz24jx	476	4	addition	addition	NN
cord-280549-bsnz24jx	476	5	to	to	IN
cord-280549-bsnz24jx	476	6	perturbing	perturb	VBG
cord-280549-bsnz24jx	476	7	the	the	DT
cord-280549-bsnz24jx	476	8	nuclear	nuclear	JJ
cord-280549-bsnz24jx	476	9	-	-	HYPH
cord-280549-bsnz24jx	476	10	import	import	NN
cord-280549-bsnz24jx	476	11	of	of	IN
cord-280549-bsnz24jx	476	12	p53	p53	NN
cord-280549-bsnz24jx	476	13	,	,	,
cord-280549-bsnz24jx	476	14	HCMV	HCMV	NNP
cord-280549-bsnz24jx	476	15	could	could	MD
cord-280549-bsnz24jx	476	16	also	also	RB
cord-280549-bsnz24jx	476	17	inhibit	inhibit	VB
cord-280549-bsnz24jx	476	18	the	the	DT
cord-280549-bsnz24jx	476	19	function	function	NN
cord-280549-bsnz24jx	476	20	of	of	IN
cord-280549-bsnz24jx	476	21	nuclear	nuclear	JJ
cord-280549-bsnz24jx	476	22	p53	p53	NN
cord-280549-bsnz24jx	476	23	through	through	IN
cord-280549-bsnz24jx	476	24	sequestering	sequester	VBG
cord-280549-bsnz24jx	476	25	it	-PRON-	PRP
cord-280549-bsnz24jx	476	26	into	into	IN
cord-280549-bsnz24jx	476	27	discrete	discrete	JJ
cord-280549-bsnz24jx	476	28	foci	foci	NN
cord-280549-bsnz24jx	476	29	,	,	,
cord-280549-bsnz24jx	476	30	viz	viz	NN
cord-280549-bsnz24jx	476	31	.	.	.
cord-280549-bsnz24jx	477	1	,	,	,
cord-280549-bsnz24jx	477	2	the	the	DT
cord-280549-bsnz24jx	477	3	replication	replication	NN
cord-280549-bsnz24jx	477	4	centers	center	NNS
cord-280549-bsnz24jx	477	5	,	,	,
cord-280549-bsnz24jx	477	6	within	within	IN
cord-280549-bsnz24jx	477	7	the	the	DT
cord-280549-bsnz24jx	477	8	nuclei	nucleus	NNS
cord-280549-bsnz24jx	477	9	of	of	IN
cord-280549-bsnz24jx	477	10	HCMVinfected	hcmvinfected	JJ
cord-280549-bsnz24jx	477	11	cells	cell	NNS
cord-280549-bsnz24jx	477	12	(	(	-LRB-
cord-280549-bsnz24jx	477	13	Fortunato	Fortunato	NNP
cord-280549-bsnz24jx	477	14	and	and	CC
cord-280549-bsnz24jx	477	15	Spector	Spector	NNP
cord-280549-bsnz24jx	477	16	,	,	,
cord-280549-bsnz24jx	477	17	1998	1998	CD
cord-280549-bsnz24jx	477	18	)	)	-RRB-
cord-280549-bsnz24jx	477	19	.	.	.
cord-280549-bsnz24jx	478	1	Changes	change	NNS
cord-280549-bsnz24jx	478	2	in	in	IN
cord-280549-bsnz24jx	478	3	the	the	DT
cord-280549-bsnz24jx	478	4	subcellular	subcellular	JJ
cord-280549-bsnz24jx	478	5	localization	localization	NN
cord-280549-bsnz24jx	478	6	of	of	IN
cord-280549-bsnz24jx	478	7	p53	p53	NN
cord-280549-bsnz24jx	478	8	were	be	VBD
cord-280549-bsnz24jx	478	9	also	also	RB
cord-280549-bsnz24jx	478	10	observed	observe	VBN
cord-280549-bsnz24jx	478	11	in	in	IN
cord-280549-bsnz24jx	478	12	two	two	CD
cord-280549-bsnz24jx	478	13	different	different	JJ
cord-280549-bsnz24jx	478	14	cell	cell	NN
cord-280549-bsnz24jx	478	15	lines	line	NNS
cord-280549-bsnz24jx	478	16	that	that	WDT
cord-280549-bsnz24jx	478	17	expressed	express	VBD
cord-280549-bsnz24jx	478	18	the	the	DT
cord-280549-bsnz24jx	478	19	HCV	HCV	NNP
cord-280549-bsnz24jx	478	20	NS5A	NS5A	NNP
cord-280549-bsnz24jx	478	21	protein	protein	NN
cord-280549-bsnz24jx	478	22	(	(	-LRB-
cord-280549-bsnz24jx	478	23	Majumder	Majumder	NNP
cord-280549-bsnz24jx	478	24	et	et	NNP
cord-280549-bsnz24jx	478	25	al	al	NNP
cord-280549-bsnz24jx	478	26	.	.	NNP
cord-280549-bsnz24jx	478	27	,	,	,
cord-280549-bsnz24jx	478	28	2001	2001	CD
cord-280549-bsnz24jx	478	29	)	)	-RRB-
cord-280549-bsnz24jx	478	30	.	.	.
cord-280549-bsnz24jx	479	1	Endogenous	endogenous	JJ
cord-280549-bsnz24jx	479	2	p53	p53	NN
cord-280549-bsnz24jx	479	3	is	be	VBZ
cord-280549-bsnz24jx	479	4	a	a	DT
cord-280549-bsnz24jx	479	5	nuclear	nuclear	JJ
cord-280549-bsnz24jx	479	6	protein	protein	NN
cord-280549-bsnz24jx	479	7	,	,	,
cord-280549-bsnz24jx	479	8	whereas	whereas	IN
cord-280549-bsnz24jx	479	9	it	-PRON-	PRP
cord-280549-bsnz24jx	479	10	was	be	VBD
cord-280549-bsnz24jx	479	11	retained	retain	VBN
cord-280549-bsnz24jx	479	12	at	at	IN
cord-280549-bsnz24jx	479	13	the	the	DT
cord-280549-bsnz24jx	479	14	perinuclear	perinuclear	NNP
cord-280549-bsnz24jx	479	15	membrane	membrane	NN
cord-280549-bsnz24jx	479	16	following	follow	VBG
cord-280549-bsnz24jx	479	17	NS5A	NS5A	NNP
cord-280549-bsnz24jx	479	18	expression	expression	NN
cord-280549-bsnz24jx	480	1	(	(	-LRB-
cord-280549-bsnz24jx	480	2	Shaulsky	Shaulsky	NNP
cord-280549-bsnz24jx	480	3	et	et	FW
cord-280549-bsnz24jx	480	4	al	al	NNP
cord-280549-bsnz24jx	480	5	.	.	NNP
cord-280549-bsnz24jx	480	6	,	,	,
cord-280549-bsnz24jx	480	7	1991	1991	CD
cord-280549-bsnz24jx	480	8	)	)	-RRB-
cord-280549-bsnz24jx	480	9	.	.	.
cord-280549-bsnz24jx	481	1	A	a	DT
cord-280549-bsnz24jx	481	2	physical	physical	JJ
cord-280549-bsnz24jx	481	3	association	association	NN
cord-280549-bsnz24jx	481	4	of	of	IN
cord-280549-bsnz24jx	481	5	NS5A	NS5A	NNP
cord-280549-bsnz24jx	481	6	with	with	IN
cord-280549-bsnz24jx	481	7	p53	p53	NN
cord-280549-bsnz24jx	481	8	was	be	VBD
cord-280549-bsnz24jx	481	9	demonstrated	demonstrate	VBN
cord-280549-bsnz24jx	481	10	both	both	CC
cord-280549-bsnz24jx	481	11	in	in	IN
cord-280549-bsnz24jx	481	12	vitro	vitro	FW
cord-280549-bsnz24jx	481	13	and	and	CC
cord-280549-bsnz24jx	481	14	in	in	IN
cord-280549-bsnz24jx	481	15	vivo	vivo	NN
cord-280549-bsnz24jx	481	16	;	;	:
cord-280549-bsnz24jx	481	17	however	however	RB
cord-280549-bsnz24jx	481	18	,	,	,
cord-280549-bsnz24jx	481	19	it	-PRON-	PRP
cord-280549-bsnz24jx	481	20	is	be	VBZ
cord-280549-bsnz24jx	481	21	not	not	RB
cord-280549-bsnz24jx	481	22	the	the	DT
cord-280549-bsnz24jx	481	23	cause	cause	NN
cord-280549-bsnz24jx	481	24	for	for	IN
cord-280549-bsnz24jx	481	25	this	this	DT
cord-280549-bsnz24jx	481	26	sequestration	sequestration	NN
cord-280549-bsnz24jx	481	27	as	as	IN
cord-280549-bsnz24jx	481	28	NS5A	NS5A	NNP
cord-280549-bsnz24jx	481	29	binding	bind	VBG
cord-280549-bsnz24jx	481	30	-	-	HYPH
cord-280549-bsnz24jx	481	31	deficient	deficient	JJ
cord-280549-bsnz24jx	481	32	p53	p53	NN
cord-280549-bsnz24jx	481	33	was	be	VBD
cord-280549-bsnz24jx	481	34	still	still	RB
cord-280549-bsnz24jx	481	35	observed	observe	VBN
cord-280549-bsnz24jx	481	36	to	to	TO
cord-280549-bsnz24jx	481	37	localize	localize	VB
cord-280549-bsnz24jx	481	38	on	on	IN
cord-280549-bsnz24jx	481	39	the	the	DT
cord-280549-bsnz24jx	481	40	perinuclear	perinuclear	NNP
cord-280549-bsnz24jx	481	41	membrane	membrane	NN
cord-280549-bsnz24jx	481	42	.	.	.
cord-280549-bsnz24jx	482	1	In	in	IN
cord-280549-bsnz24jx	482	2	accordance	accordance	NN
cord-280549-bsnz24jx	482	3	,	,	,
cord-280549-bsnz24jx	482	4	hTAF	hTAF	NNP
cord-280549-bsnz24jx	482	5	II	II	NNP
cord-280549-bsnz24jx	482	6	32	32	CD
cord-280549-bsnz24jx	482	7	,	,	,
cord-280549-bsnz24jx	482	8	a	a	DT
cord-280549-bsnz24jx	482	9	transcriptional	transcriptional	JJ
cord-280549-bsnz24jx	482	10	coactivator	coactivator	NN
cord-280549-bsnz24jx	482	11	of	of	IN
cord-280549-bsnz24jx	482	12	p53	p53	NN
cord-280549-bsnz24jx	482	13	,	,	,
cord-280549-bsnz24jx	482	14	was	be	VBD
cord-280549-bsnz24jx	482	15	also	also	RB
cord-280549-bsnz24jx	482	16	partially	partially	RB
cord-280549-bsnz24jx	482	17	sequestered	sequester	VBN
cord-280549-bsnz24jx	482	18	by	by	IN
cord-280549-bsnz24jx	482	19	NS5A	NS5A	NNP
cord-280549-bsnz24jx	482	20	in	in	IN
cord-280549-bsnz24jx	482	21	the	the	DT
cord-280549-bsnz24jx	482	22	cytoplasm	cytoplasm	NN
cord-280549-bsnz24jx	482	23	,	,	,
cord-280549-bsnz24jx	482	24	thus	thus	RB
cord-280549-bsnz24jx	482	25	suggesting	suggest	VBG
cord-280549-bsnz24jx	482	26	an	an	DT
cord-280549-bsnz24jx	482	27	indirect	indirect	JJ
cord-280549-bsnz24jx	482	28	mechanism	mechanism	NN
cord-280549-bsnz24jx	482	29	(	(	-LRB-
cord-280549-bsnz24jx	482	30	Lu	Lu	NNP
cord-280549-bsnz24jx	482	31	and	and	CC
cord-280549-bsnz24jx	482	32	Levine	Levine	NNP
cord-280549-bsnz24jx	482	33	,	,	,
cord-280549-bsnz24jx	482	34	1995	1995	CD
cord-280549-bsnz24jx	482	35	;	;	:
cord-280549-bsnz24jx	482	36	Lan	Lan	NNP
cord-280549-bsnz24jx	482	37	et	et	NNP
cord-280549-bsnz24jx	482	38	al	al	NNP
cord-280549-bsnz24jx	482	39	.	.	NNP
cord-280549-bsnz24jx	482	40	,	,	,
cord-280549-bsnz24jx	482	41	2002	2002	CD
cord-280549-bsnz24jx	482	42	)	)	-RRB-
cord-280549-bsnz24jx	482	43	.	.	.
cord-280549-bsnz24jx	483	1	Although	although	IN
cord-280549-bsnz24jx	483	2	p53	p53	NN
cord-280549-bsnz24jx	483	3	is	be	VBZ
cord-280549-bsnz24jx	483	4	known	know	VBN
cord-280549-bsnz24jx	483	5	as	as	IN
cord-280549-bsnz24jx	483	6	a	a	DT
cord-280549-bsnz24jx	483	7	tumor	tumor	NN
cord-280549-bsnz24jx	483	8	suppressor	suppressor	NN
cord-280549-bsnz24jx	483	9	gene	gene	NN
cord-280549-bsnz24jx	483	10	,	,	,
cord-280549-bsnz24jx	483	11	increasing	increase	VBG
cord-280549-bsnz24jx	483	12	evidence	evidence	NN
cord-280549-bsnz24jx	483	13	suggest	suggest	VBP
cord-280549-bsnz24jx	483	14	that	that	IN
cord-280549-bsnz24jx	483	15	nasopharyngeal	nasopharyngeal	JJ
cord-280549-bsnz24jx	483	16	carcinoma	carcinoma	NN
cord-280549-bsnz24jx	483	17	(	(	-LRB-
cord-280549-bsnz24jx	483	18	NPC	NPC	NNP
cord-280549-bsnz24jx	483	19	)	)	-RRB-
cord-280549-bsnz24jx	483	20	is	be	VBZ
cord-280549-bsnz24jx	483	21	associated	associate	VBN
cord-280549-bsnz24jx	483	22	with	with	IN
cord-280549-bsnz24jx	483	23	overexpression	overexpression	NN
cord-280549-bsnz24jx	483	24	and	and	CC
cord-280549-bsnz24jx	483	25	accumulation	accumulation	NN
cord-280549-bsnz24jx	483	26	of	of	IN
cord-280549-bsnz24jx	483	27	p53	p53	NN
cord-280549-bsnz24jx	483	28	(	(	-LRB-
cord-280549-bsnz24jx	484	1	Gulley	Gulley	NNP
cord-280549-bsnz24jx	484	2	et	et	NNP
cord-280549-bsnz24jx	484	3	al	al	NNP
cord-280549-bsnz24jx	484	4	.	.	.
cord-280549-bsnz24jx	485	1	,	,	,
cord-280549-bsnz24jx	485	2	1998	1998	CD
cord-280549-bsnz24jx	485	3	;	;	:
cord-280549-bsnz24jx	485	4	Yip	Yip	NNP
cord-280549-bsnz24jx	485	5	et	et	NNP
cord-280549-bsnz24jx	485	6	al	al	NNP
cord-280549-bsnz24jx	485	7	.	.	NNP
cord-280549-bsnz24jx	485	8	,	,	,
cord-280549-bsnz24jx	485	9	2006	2006	CD
cord-280549-bsnz24jx	485	10	)	)	-RRB-
cord-280549-bsnz24jx	485	11	.	.	.
cord-280549-bsnz24jx	486	1	It	-PRON-	PRP
cord-280549-bsnz24jx	486	2	is	be	VBZ
cord-280549-bsnz24jx	486	3	interesting	interesting	JJ
cord-280549-bsnz24jx	486	4	to	to	TO
cord-280549-bsnz24jx	486	5	find	find	VB
cord-280549-bsnz24jx	486	6	that	that	IN
cord-280549-bsnz24jx	486	7	the	the	DT
cord-280549-bsnz24jx	486	8	late	late	JJ
cord-280549-bsnz24jx	486	9	membrane	membrane	NN
cord-280549-bsnz24jx	486	10	protein	protein	NN
cord-280549-bsnz24jx	486	11	1	1	CD
cord-280549-bsnz24jx	486	12	(	(	-LRB-
cord-280549-bsnz24jx	486	13	LMP1	LMP1	NNP
cord-280549-bsnz24jx	486	14	)	)	-RRB-
cord-280549-bsnz24jx	486	15	of	of	IN
cord-280549-bsnz24jx	486	16	EBV	EBV	NNP
cord-280549-bsnz24jx	486	17	not	not	RB
cord-280549-bsnz24jx	486	18	only	only	RB
cord-280549-bsnz24jx	486	19	upregulates	upregulate	VBZ
cord-280549-bsnz24jx	486	20	the	the	DT
cord-280549-bsnz24jx	486	21	expression	expression	NN
cord-280549-bsnz24jx	486	22	and	and	CC
cord-280549-bsnz24jx	486	23	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	486	24	of	of	IN
cord-280549-bsnz24jx	486	25	p53	p53	NN
cord-280549-bsnz24jx	486	26	and	and	CC
cord-280549-bsnz24jx	486	27	survivin	survivin	NN
cord-280549-bsnz24jx	486	28	,	,	,
cord-280549-bsnz24jx	486	29	which	which	WDT
cord-280549-bsnz24jx	486	30	possesses	possess	VBZ
cord-280549-bsnz24jx	486	31	a	a	DT
cord-280549-bsnz24jx	486	32	p53-binding	p53-binde	VBG
cord-280549-bsnz24jx	486	33	element	element	NN
cord-280549-bsnz24jx	486	34	in	in	IN
cord-280549-bsnz24jx	486	35	its	-PRON-	PRP$
cord-280549-bsnz24jx	486	36	promoter	promoter	NN
cord-280549-bsnz24jx	486	37	region	region	NN
cord-280549-bsnz24jx	486	38	and	and	CC
cord-280549-bsnz24jx	486	39	facilitates	facilitate	VBZ
cord-280549-bsnz24jx	486	40	G1	G1	NNP
cord-280549-bsnz24jx	486	41	/	/	SYM
cord-280549-bsnz24jx	486	42	S	s	NN
cord-280549-bsnz24jx	486	43	progression	progression	NN
cord-280549-bsnz24jx	486	44	by	by	IN
cord-280549-bsnz24jx	486	45	interacting	interact	VBG
cord-280549-bsnz24jx	486	46	with	with	IN
cord-280549-bsnz24jx	486	47	CDK4	CDK4	NNP
cord-280549-bsnz24jx	486	48	in	in	IN
cord-280549-bsnz24jx	486	49	the	the	DT
cord-280549-bsnz24jx	486	50	nucleus	nucleus	NN
cord-280549-bsnz24jx	487	1	(	(	-LRB-
cord-280549-bsnz24jx	487	2	Suzuki	Suzuki	NNP
cord-280549-bsnz24jx	487	3	et	et	FW
cord-280549-bsnz24jx	487	4	al	al	NNP
cord-280549-bsnz24jx	487	5	.	.	NNP
cord-280549-bsnz24jx	487	6	,	,	,
cord-280549-bsnz24jx	487	7	2000	2000	CD
cord-280549-bsnz24jx	487	8	;	;	:
cord-280549-bsnz24jx	487	9	Hoffman	Hoffman	NNP
cord-280549-bsnz24jx	487	10	et	et	NNP
cord-280549-bsnz24jx	487	11	al	al	NNP
cord-280549-bsnz24jx	487	12	.	.	NNP
cord-280549-bsnz24jx	487	13	,	,	,
cord-280549-bsnz24jx	487	14	2002	2002	CD
cord-280549-bsnz24jx	488	1	;	;	:
cord-280549-bsnz24jx	488	2	Mirza	Mirza	NNP
cord-280549-bsnz24jx	488	3	et	et	NNP
cord-280549-bsnz24jx	488	4	al	al	NNP
cord-280549-bsnz24jx	488	5	.	.	NNP
cord-280549-bsnz24jx	488	6	,	,	,
cord-280549-bsnz24jx	488	7	2002	2002	CD
cord-280549-bsnz24jx	488	8	;	;	:
cord-280549-bsnz24jx	488	9	Guo	Guo	NNP
cord-280549-bsnz24jx	488	10	et	et	FW
cord-280549-bsnz24jx	488	11	al	al	NNP
cord-280549-bsnz24jx	488	12	.	.	NNP
cord-280549-bsnz24jx	488	13	,	,	,
cord-280549-bsnz24jx	488	14	2012	2012	CD
cord-280549-bsnz24jx	488	15	)	)	-RRB-
cord-280549-bsnz24jx	488	16	,	,	,
cord-280549-bsnz24jx	488	17	but	but	CC
cord-280549-bsnz24jx	488	18	also	also	RB
cord-280549-bsnz24jx	488	19	increases	increase	VBZ
cord-280549-bsnz24jx	488	20	the	the	DT
cord-280549-bsnz24jx	488	21	nuclear	nuclear	JJ
cord-280549-bsnz24jx	488	22	localization	localization	NN
cord-280549-bsnz24jx	488	23	of	of	IN
cord-280549-bsnz24jx	488	24	both	both	DT
cord-280549-bsnz24jx	488	25	proteins	protein	NNS
cord-280549-bsnz24jx	489	1	(	(	-LRB-
cord-280549-bsnz24jx	489	2	Guo	Guo	NNP
cord-280549-bsnz24jx	489	3	et	et	FW
cord-280549-bsnz24jx	489	4	al	al	NNP
cord-280549-bsnz24jx	489	5	.	.	NNP
cord-280549-bsnz24jx	489	6	,	,	,
cord-280549-bsnz24jx	489	7	2012	2012	CD
cord-280549-bsnz24jx	489	8	)	)	-RRB-
cord-280549-bsnz24jx	489	9	.	.	.
cord-280549-bsnz24jx	490	1	Expression	expression	NN
cord-280549-bsnz24jx	490	2	of	of	IN
cord-280549-bsnz24jx	490	3	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	490	4	Vpr	Vpr	NNP
cord-280549-bsnz24jx	490	5	could	could	MD
cord-280549-bsnz24jx	490	6	induce	induce	VB
cord-280549-bsnz24jx	490	7	localized	localize	VBN
cord-280549-bsnz24jx	490	8	-	-	HYPH
cord-280549-bsnz24jx	490	9	disruption	disruption	NN
cord-280549-bsnz24jx	490	10	in	in	IN
cord-280549-bsnz24jx	490	11	the	the	DT
cord-280549-bsnz24jx	490	12	lamin	lamin	NN
cord-280549-bsnz24jx	490	13	architecture	architecture	NN
cord-280549-bsnz24jx	490	14	,	,	,
cord-280549-bsnz24jx	490	15	which	which	WDT
cord-280549-bsnz24jx	490	16	is	be	VBZ
cord-280549-bsnz24jx	490	17	known	know	VBN
cord-280549-bsnz24jx	490	18	to	to	TO
cord-280549-bsnz24jx	490	19	interfere	interfere	VB
cord-280549-bsnz24jx	490	20	with	with	IN
cord-280549-bsnz24jx	490	21	DNA	dna	NN
cord-280549-bsnz24jx	490	22	synthesis	synthesis	NN
cord-280549-bsnz24jx	490	23	and	and	CC
cord-280549-bsnz24jx	490	24	changes	change	NNS
cord-280549-bsnz24jx	490	25	in	in	IN
cord-280549-bsnz24jx	490	26	the	the	DT
cord-280549-bsnz24jx	490	27	intracellular	intracellular	JJ
cord-280549-bsnz24jx	490	28	trafficking	trafficking	NN
cord-280549-bsnz24jx	490	29	of	of	IN
cord-280549-bsnz24jx	490	30	cell	cell	NN
cord-280549-bsnz24jx	490	31	cycle	cycle	NN
cord-280549-bsnz24jx	490	32	regulators	regulator	NNS
cord-280549-bsnz24jx	490	33	(	(	-LRB-
cord-280549-bsnz24jx	490	34	Moir	Moir	NNP
cord-280549-bsnz24jx	490	35	et	et	FW
cord-280549-bsnz24jx	490	36	al	al	NNP
cord-280549-bsnz24jx	490	37	.	.	NNP
cord-280549-bsnz24jx	490	38	,	,	,
cord-280549-bsnz24jx	490	39	2000	2000	CD
cord-280549-bsnz24jx	490	40	;	;	:
cord-280549-bsnz24jx	490	41	de	de	NNP
cord-280549-bsnz24jx	490	42	Noronha	Noronha	NNP
cord-280549-bsnz24jx	490	43	et	et	NNP
cord-280549-bsnz24jx	490	44	al	al	NNP
cord-280549-bsnz24jx	490	45	.	.	NNP
cord-280549-bsnz24jx	490	46	,	,	,
cord-280549-bsnz24jx	490	47	2001	2001	CD
cord-280549-bsnz24jx	490	48	)	)	-RRB-
cord-280549-bsnz24jx	490	49	.	.	.
cord-280549-bsnz24jx	491	1	This	this	DT
cord-280549-bsnz24jx	491	2	structural	structural	JJ
cord-280549-bsnz24jx	491	3	defect	defect	NN
cord-280549-bsnz24jx	491	4	of	of	IN
cord-280549-bsnz24jx	491	5	lamin	lamin	NN
cord-280549-bsnz24jx	491	6	leads	lead	VBZ
cord-280549-bsnz24jx	491	7	to	to	IN
cord-280549-bsnz24jx	491	8	the	the	DT
cord-280549-bsnz24jx	491	9	formation	formation	NN
cord-280549-bsnz24jx	491	10	of	of	IN
cord-280549-bsnz24jx	491	11	nuclear	nuclear	JJ
cord-280549-bsnz24jx	491	12	envelope	envelope	NN
cord-280549-bsnz24jx	491	13	herniations	herniation	NNS
cord-280549-bsnz24jx	491	14	as	as	IN
cord-280549-bsnz24jx	491	15	revealed	reveal	VBN
cord-280549-bsnz24jx	491	16	by	by	IN
cord-280549-bsnz24jx	491	17	immunofluorescence	immunofluorescence	NN
cord-280549-bsnz24jx	491	18	,	,	,
cord-280549-bsnz24jx	491	19	resulting	result	VBG
cord-280549-bsnz24jx	491	20	in	in	IN
cord-280549-bsnz24jx	491	21	changes	change	NNS
cord-280549-bsnz24jx	491	22	in	in	IN
cord-280549-bsnz24jx	491	23	the	the	DT
cord-280549-bsnz24jx	491	24	subcellular	subcellular	JJ
cord-280549-bsnz24jx	491	25	compartmentalization	compartmentalization	NN
cord-280549-bsnz24jx	491	26	of	of	IN
cord-280549-bsnz24jx	491	27	Cdc25C	Cdc25C	NNP
cord-280549-bsnz24jx	491	28	,	,	,
cord-280549-bsnz24jx	491	29	cyclin	cyclin	NN
cord-280549-bsnz24jx	491	30	B1	b1	NN
cord-280549-bsnz24jx	491	31	,	,	,
cord-280549-bsnz24jx	491	32	and	and	CC
cord-280549-bsnz24jx	491	33	Wee1	Wee1	NNP
cord-280549-bsnz24jx	491	34	(	(	-LRB-
cord-280549-bsnz24jx	491	35	de	de	FW
cord-280549-bsnz24jx	491	36	Noronha	Noronha	NNP
cord-280549-bsnz24jx	491	37	et	et	NNP
cord-280549-bsnz24jx	491	38	al	al	NNP
cord-280549-bsnz24jx	491	39	.	.	NNP
cord-280549-bsnz24jx	491	40	,	,	,
cord-280549-bsnz24jx	491	41	2001	2001	CD
cord-280549-bsnz24jx	491	42	)	)	-RRB-
cord-280549-bsnz24jx	491	43	.	.	.
cord-280549-bsnz24jx	492	1	Thus	thus	RB
cord-280549-bsnz24jx	492	2	,	,	,
cord-280549-bsnz24jx	492	3	interaction	interaction	NN
cord-280549-bsnz24jx	492	4	of	of	IN
cord-280549-bsnz24jx	492	5	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	492	6	Vpr	Vpr	NNP
cord-280549-bsnz24jx	492	7	with	with	IN
cord-280549-bsnz24jx	492	8	the	the	DT
cord-280549-bsnz24jx	492	9	14	14	CD
cord-280549-bsnz24jx	492	10	-	-	SYM
cord-280549-bsnz24jx	492	11	3	3	CD
cord-280549-bsnz24jx	492	12	-	-	HYPH
cord-280549-bsnz24jx	492	13	3σ	3σ	CD
cord-280549-bsnz24jx	492	14	scaffolding	scaffolding	NN
cord-280549-bsnz24jx	492	15	protein	protein	NN
cord-280549-bsnz24jx	492	16	,	,	,
cord-280549-bsnz24jx	492	17	a	a	DT
cord-280549-bsnz24jx	492	18	G2	G2	NNP
cord-280549-bsnz24jx	492	19	/	/	SYM
cord-280549-bsnz24jx	492	20	M	M	NNP
cord-280549-bsnz24jx	492	21	transition	transition	NN
cord-280549-bsnz24jx	492	22	regulator	regulator	NN
cord-280549-bsnz24jx	492	23	that	that	WDT
cord-280549-bsnz24jx	492	24	inactivates	inactivate	VBZ
cord-280549-bsnz24jx	492	25	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	492	26	by	by	IN
cord-280549-bsnz24jx	492	27	changing	change	VBG
cord-280549-bsnz24jx	492	28	its	-PRON-	PRP$
cord-280549-bsnz24jx	492	29	subcellular	subcellular	JJ
cord-280549-bsnz24jx	492	30	localization	localization	NN
cord-280549-bsnz24jx	492	31	and/or	and/or	CC
cord-280549-bsnz24jx	492	32	stability	stability	NN
cord-280549-bsnz24jx	493	1	(	(	-LRB-
cord-280549-bsnz24jx	493	2	Fu	Fu	NNP
cord-280549-bsnz24jx	493	3	et	et	FW
cord-280549-bsnz24jx	493	4	al	al	NNP
cord-280549-bsnz24jx	493	5	.	.	NNP
cord-280549-bsnz24jx	493	6	,	,	,
cord-280549-bsnz24jx	493	7	2000	2000	CD
cord-280549-bsnz24jx	493	8	;	;	:
cord-280549-bsnz24jx	494	1	Muslin	Muslin	NNP
cord-280549-bsnz24jx	494	2	and	and	CC
cord-280549-bsnz24jx	494	3	Xing	Xing	NNP
cord-280549-bsnz24jx	494	4	,	,	,
cord-280549-bsnz24jx	494	5	2000	2000	CD
cord-280549-bsnz24jx	494	6	)	)	-RRB-
cord-280549-bsnz24jx	494	7	,	,	,
cord-280549-bsnz24jx	494	8	has	have	VBZ
cord-280549-bsnz24jx	494	9	been	be	VBN
cord-280549-bsnz24jx	494	10	implicated	implicate	VBN
cord-280549-bsnz24jx	494	11	in	in	IN
cord-280549-bsnz24jx	494	12	Vprinduced	vprinduced	JJ
cord-280549-bsnz24jx	494	13	cell	cell	NN
cord-280549-bsnz24jx	494	14	cycle	cycle	NN
cord-280549-bsnz24jx	494	15	perturbation	perturbation	NN
cord-280549-bsnz24jx	494	16	(	(	-LRB-
cord-280549-bsnz24jx	494	17	Peng	Peng	NNP
cord-280549-bsnz24jx	494	18	et	et	NNP
cord-280549-bsnz24jx	494	19	al	al	NNP
cord-280549-bsnz24jx	494	20	.	.	NNP
cord-280549-bsnz24jx	494	21	,	,	,
cord-280549-bsnz24jx	494	22	1997	1997	CD
cord-280549-bsnz24jx	494	23	;	;	:
cord-280549-bsnz24jx	494	24	Lopez	Lopez	NNP
cord-280549-bsnz24jx	494	25	-	-	HYPH
cord-280549-bsnz24jx	494	26	Girona	Girona	NNP
cord-280549-bsnz24jx	494	27	et	et	NNP
cord-280549-bsnz24jx	494	28	al	al	NNP
cord-280549-bsnz24jx	494	29	.	.	NNP
cord-280549-bsnz24jx	494	30	,	,	,
cord-280549-bsnz24jx	494	31	1999	1999	CD
cord-280549-bsnz24jx	494	32	;	;	:
cord-280549-bsnz24jx	494	33	Laronga	Laronga	NNP
cord-280549-bsnz24jx	494	34	et	et	NNP
cord-280549-bsnz24jx	494	35	al	al	NNP
cord-280549-bsnz24jx	494	36	.	.	.
cord-280549-bsnz24jx	495	1	,	,	,
cord-280549-bsnz24jx	495	2	2000	2000	CD
cord-280549-bsnz24jx	495	3	;	;	:
cord-280549-bsnz24jx	495	4	Kino	Kino	NNP
cord-280549-bsnz24jx	495	5	et	et	NNP
cord-280549-bsnz24jx	495	6	al	al	NNP
cord-280549-bsnz24jx	495	7	.	.	NNP
cord-280549-bsnz24jx	495	8	,	,	,
cord-280549-bsnz24jx	495	9	2005	2005	CD
cord-280549-bsnz24jx	495	10	)	)	-RRB-
cord-280549-bsnz24jx	495	11	.	.	.
cord-280549-bsnz24jx	496	1	Vpr	Vpr	NNP
cord-280549-bsnz24jx	496	2	could	could	MD
cord-280549-bsnz24jx	496	3	mediate	mediate	VB
cord-280549-bsnz24jx	496	4	protein	protein	NN
cord-280549-bsnz24jx	496	5	assembly	assembly	NN
cord-280549-bsnz24jx	496	6	among	among	IN
cord-280549-bsnz24jx	496	7	14	14	CD
cord-280549-bsnz24jx	496	8	-	-	SYM
cord-280549-bsnz24jx	496	9	3	3	CD
cord-280549-bsnz24jx	496	10	-	-	HYPH
cord-280549-bsnz24jx	496	11	3σ	3σ	CD
cord-280549-bsnz24jx	496	12	,	,	,
cord-280549-bsnz24jx	496	13	Cdc25C	Cdc25C	NNP
cord-280549-bsnz24jx	496	14	,	,	,
cord-280549-bsnz24jx	496	15	CDK1	CDK1	NNP
cord-280549-bsnz24jx	496	16	,	,	,
cord-280549-bsnz24jx	496	17	and	and	CC
cord-280549-bsnz24jx	496	18	cyclin	cyclin	NN
cord-280549-bsnz24jx	496	19	B1	b1	NN
cord-280549-bsnz24jx	496	20	,	,	,
cord-280549-bsnz24jx	496	21	leading	lead	VBG
cord-280549-bsnz24jx	496	22	to	to	IN
cord-280549-bsnz24jx	496	23	G2	G2	NNP
cord-280549-bsnz24jx	496	24	/	/	SYM
cord-280549-bsnz24jx	496	25	M	M	NNP
cord-280549-bsnz24jx	496	26	arrest	arrest	NN
cord-280549-bsnz24jx	496	27	by	by	IN
cord-280549-bsnz24jx	496	28	either	either	DT
cord-280549-bsnz24jx	496	29	sequestering	sequester	VBG
cord-280549-bsnz24jx	496	30	Cdc25	Cdc25	NNP
cord-280549-bsnz24jx	496	31	in	in	IN
cord-280549-bsnz24jx	496	32	the	the	DT
cord-280549-bsnz24jx	496	33	cytoplasm	cytoplasm	NN
cord-280549-bsnz24jx	496	34	or	or	CC
cord-280549-bsnz24jx	496	35	impairing	impair	VBG
cord-280549-bsnz24jx	496	36	the	the	DT
cord-280549-bsnz24jx	496	37	normal	normal	JJ
cord-280549-bsnz24jx	496	38	association	association	NN
cord-280549-bsnz24jx	496	39	of	of	IN
cord-280549-bsnz24jx	496	40	14	14	CD
cord-280549-bsnz24jx	496	41	-	-	SYM
cord-280549-bsnz24jx	496	42	3	3	CD
cord-280549-bsnz24jx	496	43	-	-	HYPH
cord-280549-bsnz24jx	496	44	3σ	3σ	CD
cord-280549-bsnz24jx	496	45	with	with	IN
cord-280549-bsnz24jx	496	46	centrosomal	centrosomal	NNP
cord-280549-bsnz24jx	496	47	proteins	protein	NNS
cord-280549-bsnz24jx	496	48	(	(	-LRB-
cord-280549-bsnz24jx	496	49	Kino	Kino	NNP
cord-280549-bsnz24jx	496	50	et	et	NNP
cord-280549-bsnz24jx	496	51	al	al	NNP
cord-280549-bsnz24jx	496	52	.	.	NNP
cord-280549-bsnz24jx	496	53	,	,	,
cord-280549-bsnz24jx	496	54	2005	2005	CD
cord-280549-bsnz24jx	496	55	;	;	:
cord-280549-bsnz24jx	497	1	Bolton	Bolton	NNP
cord-280549-bsnz24jx	497	2	et	et	NNP
cord-280549-bsnz24jx	497	3	al	al	NNP
cord-280549-bsnz24jx	497	4	.	.	NNP
cord-280549-bsnz24jx	497	5	,	,	,
cord-280549-bsnz24jx	497	6	2008	2008	CD
cord-280549-bsnz24jx	497	7	)	)	-RRB-
cord-280549-bsnz24jx	497	8	.	.	.
cord-280549-bsnz24jx	498	1	An	an	DT
cord-280549-bsnz24jx	498	2	association	association	NN
cord-280549-bsnz24jx	498	3	of	of	IN
cord-280549-bsnz24jx	498	4	Vpr	Vpr	NNP
cord-280549-bsnz24jx	498	5	with	with	IN
cord-280549-bsnz24jx	498	6	MAPKAP	MAPKAP	NNP
cord-280549-bsnz24jx	498	7	kinase-2	kinase-2	NNP
cord-280549-bsnz24jx	498	8	(	(	-LRB-
cord-280549-bsnz24jx	498	9	MK2	MK2	NNP
cord-280549-bsnz24jx	498	10	)	)	-RRB-
cord-280549-bsnz24jx	498	11	,	,	,
cord-280549-bsnz24jx	498	12	a	a	DT
cord-280549-bsnz24jx	498	13	possible	possible	JJ
cord-280549-bsnz24jx	498	14	regulatory	regulatory	JJ
cord-280549-bsnz24jx	498	15	kinase	kinase	NN
cord-280549-bsnz24jx	498	16	of	of	IN
cord-280549-bsnz24jx	498	17	Cdc25	Cdc25	NNP
cord-280549-bsnz24jx	498	18	,	,	,
cord-280549-bsnz24jx	498	19	was	be	VBD
cord-280549-bsnz24jx	498	20	reported	report	VBN
cord-280549-bsnz24jx	498	21	by	by	IN
cord-280549-bsnz24jx	498	22	Huard	Huard	NNP
cord-280549-bsnz24jx	498	23	et	et	NNP
cord-280549-bsnz24jx	498	24	al	al	NNP
cord-280549-bsnz24jx	498	25	.	.	.
cord-280549-bsnz24jx	499	1	(	(	-LRB-
cord-280549-bsnz24jx	499	2	2008	2008	CD
cord-280549-bsnz24jx	499	3	)	)	-RRB-
cord-280549-bsnz24jx	499	4	.	.	.
cord-280549-bsnz24jx	500	1	Although	although	IN
cord-280549-bsnz24jx	500	2	the	the	DT
cord-280549-bsnz24jx	500	3	relevance	relevance	NN
cord-280549-bsnz24jx	500	4	of	of	IN
cord-280549-bsnz24jx	500	5	this	this	DT
cord-280549-bsnz24jx	500	6	interaction	interaction	NN
cord-280549-bsnz24jx	500	7	in	in	IN
cord-280549-bsnz24jx	500	8	Vprmediated	Vprmediated	NNP
cord-280549-bsnz24jx	500	9	cell	cell	NN
cord-280549-bsnz24jx	500	10	cycle	cycle	NN
cord-280549-bsnz24jx	500	11	arrest	arrest	NN
cord-280549-bsnz24jx	500	12	needs	need	VBZ
cord-280549-bsnz24jx	500	13	further	further	JJ
cord-280549-bsnz24jx	500	14	investigation	investigation	NN
cord-280549-bsnz24jx	500	15	,	,	,
cord-280549-bsnz24jx	500	16	it	-PRON-	PRP
cord-280549-bsnz24jx	500	17	appears	appear	VBZ
cord-280549-bsnz24jx	500	18	that	that	IN
cord-280549-bsnz24jx	500	19	MK2	MK2	NNP
cord-280549-bsnz24jx	500	20	is	be	VBZ
cord-280549-bsnz24jx	500	21	required	require	VBN
cord-280549-bsnz24jx	500	22	for	for	IN
cord-280549-bsnz24jx	500	23	Vpr	Vpr	NNP
cord-280549-bsnz24jx	500	24	-	-	HYPH
cord-280549-bsnz24jx	500	25	induced	induce	VBN
cord-280549-bsnz24jx	500	26	Cdc25	Cdc25	NNP
cord-280549-bsnz24jx	500	27	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	500	28	and	and	CC
cord-280549-bsnz24jx	500	29	nuclear	nuclear	JJ
cord-280549-bsnz24jx	500	30	export	export	NN
cord-280549-bsnz24jx	500	31	(	(	-LRB-
cord-280549-bsnz24jx	500	32	López	López	NNP
cord-280549-bsnz24jx	500	33	-	-	HYPH
cord-280549-bsnz24jx	500	34	Avilés	Avilés	NNP
cord-280549-bsnz24jx	500	35	et	et	NNP
cord-280549-bsnz24jx	500	36	al	al	NNP
cord-280549-bsnz24jx	500	37	.	.	NNP
cord-280549-bsnz24jx	500	38	,	,	,
cord-280549-bsnz24jx	500	39	2005	2005	CD
cord-280549-bsnz24jx	500	40	;	;	:
cord-280549-bsnz24jx	500	41	Manke	Manke	NNP
cord-280549-bsnz24jx	500	42	et	et	FW
cord-280549-bsnz24jx	500	43	al	al	NNP
cord-280549-bsnz24jx	500	44	.	.	NNP
cord-280549-bsnz24jx	500	45	,	,	,
cord-280549-bsnz24jx	500	46	2005	2005	CD
cord-280549-bsnz24jx	500	47	;	;	:
cord-280549-bsnz24jx	500	48	Huard	Huard	NNP
cord-280549-bsnz24jx	500	49	et	et	NNP
cord-280549-bsnz24jx	500	50	al	al	NNP
cord-280549-bsnz24jx	500	51	.	.	NNP
cord-280549-bsnz24jx	500	52	,	,	,
cord-280549-bsnz24jx	500	53	2008	2008	CD
cord-280549-bsnz24jx	500	54	)	)	-RRB-
cord-280549-bsnz24jx	500	55	.	.	.
cord-280549-bsnz24jx	501	1	The	the	DT
cord-280549-bsnz24jx	501	2	accessory	accessory	NN
cord-280549-bsnz24jx	501	3	protein	protein	NN
cord-280549-bsnz24jx	501	4	viral	viral	JJ
cord-280549-bsnz24jx	501	5	infectivity	infectivity	NN
cord-280549-bsnz24jx	501	6	factor	factor	NN
cord-280549-bsnz24jx	501	7	(	(	-LRB-
cord-280549-bsnz24jx	501	8	Vif	Vif	NNP
cord-280549-bsnz24jx	501	9	)	)	-RRB-
cord-280549-bsnz24jx	501	10	of	of	IN
cord-280549-bsnz24jx	501	11	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	501	12	also	also	RB
cord-280549-bsnz24jx	501	13	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	501	14	cell	cell	NN
cord-280549-bsnz24jx	501	15	cycle	cycle	NN
cord-280549-bsnz24jx	501	16	progression	progression	NN
cord-280549-bsnz24jx	501	17	at	at	IN
cord-280549-bsnz24jx	501	18	the	the	DT
cord-280549-bsnz24jx	501	19	G2	G2	NNP
cord-280549-bsnz24jx	501	20	phase	phase	NN
cord-280549-bsnz24jx	501	21	by	by	IN
cord-280549-bsnz24jx	501	22	interfering	interfere	VBG
cord-280549-bsnz24jx	501	23	with	with	IN
cord-280549-bsnz24jx	501	24	the	the	DT
cord-280549-bsnz24jx	501	25	nuclear	nuclear	JJ
cord-280549-bsnz24jx	501	26	translocation	translocation	NN
cord-280549-bsnz24jx	501	27	of	of	IN
cord-280549-bsnz24jx	501	28	CDK1	CDK1	NNP
cord-280549-bsnz24jx	501	29	FIGURE	FIGURE	NNP
cord-280549-bsnz24jx	501	30	4	4	CD
cord-280549-bsnz24jx	501	31	|	|	NNP
cord-280549-bsnz24jx	501	32	Cell	Cell	NNP
cord-280549-bsnz24jx	501	33	cycle	cycle	NN
cord-280549-bsnz24jx	501	34	subversion	subversion	NN
cord-280549-bsnz24jx	501	35	by	by	IN
cord-280549-bsnz24jx	501	36	protein	protein	NN
cord-280549-bsnz24jx	501	37	redistribution	redistribution	NN
cord-280549-bsnz24jx	501	38	.	.	.
cord-280549-bsnz24jx	502	1	(	(	-LRB-
cord-280549-bsnz24jx	502	2	A	a	DT
cord-280549-bsnz24jx	502	3	)	)	-RRB-
cord-280549-bsnz24jx	502	4	Nonstructural	nonstructural	JJ
cord-280549-bsnz24jx	502	5	protein	protein	NN
cord-280549-bsnz24jx	502	6	1	1	CD
cord-280549-bsnz24jx	502	7	(	(	-LRB-
cord-280549-bsnz24jx	502	8	NS1	ns1	NN
cord-280549-bsnz24jx	502	9	)	)	-RRB-
cord-280549-bsnz24jx	502	10	of	of	IN
cord-280549-bsnz24jx	502	11	human	human	JJ
cord-280549-bsnz24jx	502	12	parvovirus	parvovirus	NN
cord-280549-bsnz24jx	502	13	B19	B19	NNP
cord-280549-bsnz24jx	502	14	(	(	-LRB-
cord-280549-bsnz24jx	502	15	B19V	b19v	NN
cord-280549-bsnz24jx	502	16	)	)	-RRB-
cord-280549-bsnz24jx	502	17	leads	lead	VBZ
cord-280549-bsnz24jx	502	18	to	to	IN
cord-280549-bsnz24jx	502	19	G2	G2	NNP
cord-280549-bsnz24jx	502	20	arrest	arrest	NN
cord-280549-bsnz24jx	502	21	,	,	,
cord-280549-bsnz24jx	502	22	which	which	WDT
cord-280549-bsnz24jx	502	23	is	be	VBZ
cord-280549-bsnz24jx	502	24	mediated	mediate	VBN
cord-280549-bsnz24jx	502	25	by	by	IN
cord-280549-bsnz24jx	502	26	upregulating	upregulate	VBG
cord-280549-bsnz24jx	502	27	nuclear	nuclear	JJ
cord-280549-bsnz24jx	502	28	localization	localization	NN
cord-280549-bsnz24jx	502	29	of	of	IN
cord-280549-bsnz24jx	502	30	repressive	repressive	JJ
cord-280549-bsnz24jx	502	31	E2F4	E2F4	NNP
cord-280549-bsnz24jx	502	32	and	and	CC
cord-280549-bsnz24jx	502	33	E2F5	E2F5	NNP
cord-280549-bsnz24jx	502	34	transcription	transcription	NN
cord-280549-bsnz24jx	502	35	factors	factor	NNS
cord-280549-bsnz24jx	502	36	(	(	-LRB-
cord-280549-bsnz24jx	502	37	Wan	Wan	NNP
cord-280549-bsnz24jx	502	38	et	et	NNP
cord-280549-bsnz24jx	502	39	al	al	NNP
cord-280549-bsnz24jx	502	40	.	.	NNP
cord-280549-bsnz24jx	502	41	,	,	,
cord-280549-bsnz24jx	502	42	2010	2010	CD
cord-280549-bsnz24jx	502	43	)	)	-RRB-
cord-280549-bsnz24jx	502	44	.	.	.
cord-280549-bsnz24jx	503	1	(	(	-LRB-
cord-280549-bsnz24jx	503	2	B	b	NN
cord-280549-bsnz24jx	503	3	)	)	-RRB-
cord-280549-bsnz24jx	503	4	Cyclin	Cyclin	NNP
cord-280549-bsnz24jx	503	5	D3	D3	NNP
cord-280549-bsnz24jx	503	6	needs	need	VBZ
cord-280549-bsnz24jx	503	7	to	to	TO
cord-280549-bsnz24jx	503	8	be	be	VB
cord-280549-bsnz24jx	503	9	imported	import	VBN
cord-280549-bsnz24jx	503	10	into	into	IN
cord-280549-bsnz24jx	503	11	the	the	DT
cord-280549-bsnz24jx	503	12	nucleus	nucleus	NN
cord-280549-bsnz24jx	503	13	to	to	TO
cord-280549-bsnz24jx	503	14	assist	assist	VB
cord-280549-bsnz24jx	503	15	G0	G0	NNP
cord-280549-bsnz24jx	503	16	/	/	SYM
cord-280549-bsnz24jx	503	17	G1	G1	NNP
cord-280549-bsnz24jx	503	18	cell	cell	NN
cord-280549-bsnz24jx	503	19	cycle	cycle	NN
cord-280549-bsnz24jx	503	20	progression	progression	NN
cord-280549-bsnz24jx	503	21	(	(	-LRB-
cord-280549-bsnz24jx	503	22	Mahony	Mahony	NNP
cord-280549-bsnz24jx	503	23	et	et	NNP
cord-280549-bsnz24jx	503	24	al	al	NNP
cord-280549-bsnz24jx	503	25	.	.	NNP
cord-280549-bsnz24jx	503	26	,	,	,
cord-280549-bsnz24jx	503	27	1998	1998	CD
cord-280549-bsnz24jx	503	28	)	)	-RRB-
cord-280549-bsnz24jx	503	29	.	.	.
cord-280549-bsnz24jx	504	1	Influenza	Influenza	NNP
cord-280549-bsnz24jx	504	2	A	a	DT
cord-280549-bsnz24jx	504	3	virus	virus	NN
cord-280549-bsnz24jx	504	4	infection	infection	NN
cord-280549-bsnz24jx	504	5	perturbs	perturb	VBZ
cord-280549-bsnz24jx	504	6	cell	cell	NN
cord-280549-bsnz24jx	504	7	cycle	cycle	NN
cord-280549-bsnz24jx	504	8	progression	progression	NN
cord-280549-bsnz24jx	504	9	by	by	IN
cord-280549-bsnz24jx	504	10	redistributing	redistribute	VBG
cord-280549-bsnz24jx	504	11	cyclin	cyclin	NN
cord-280549-bsnz24jx	504	12	D3	D3	NNP
cord-280549-bsnz24jx	504	13	from	from	IN
cord-280549-bsnz24jx	504	14	the	the	DT
cord-280549-bsnz24jx	504	15	nucleus	nucleus	NN
cord-280549-bsnz24jx	504	16	to	to	IN
cord-280549-bsnz24jx	504	17	the	the	DT
cord-280549-bsnz24jx	504	18	cytoplasm	cytoplasm	NN
cord-280549-bsnz24jx	504	19	,	,	,
cord-280549-bsnz24jx	504	20	triggering	trigger	VBG
cord-280549-bsnz24jx	504	21	its	-PRON-	PRP$
cord-280549-bsnz24jx	504	22	proteasomal	proteasomal	JJ
cord-280549-bsnz24jx	504	23	degradation	degradation	NN
cord-280549-bsnz24jx	504	24	(	(	-LRB-
cord-280549-bsnz24jx	504	25	Fan	fan	NN
cord-280549-bsnz24jx	504	26	et	et	NNP
cord-280549-bsnz24jx	504	27	al	al	NNP
cord-280549-bsnz24jx	504	28	.	.	NNP
cord-280549-bsnz24jx	504	29	,	,	,
cord-280549-bsnz24jx	504	30	2017	2017	CD
cord-280549-bsnz24jx	504	31	)	)	-RRB-
cord-280549-bsnz24jx	504	32	.	.	.
cord-280549-bsnz24jx	505	1	(	(	-LRB-
cord-280549-bsnz24jx	505	2	C	C	NNP
cord-280549-bsnz24jx	505	3	)	)	-RRB-
cord-280549-bsnz24jx	505	4	Expression	expression	NN
cord-280549-bsnz24jx	505	5	of	of	IN
cord-280549-bsnz24jx	505	6	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	505	7	Vpr	Vpr	NNP
cord-280549-bsnz24jx	505	8	induces	induce	VBZ
cord-280549-bsnz24jx	505	9	localized	localize	VBN
cord-280549-bsnz24jx	505	10	-	-	HYPH
cord-280549-bsnz24jx	505	11	disruption	disruption	NN
cord-280549-bsnz24jx	505	12	in	in	IN
cord-280549-bsnz24jx	505	13	the	the	DT
cord-280549-bsnz24jx	505	14	lamin	lamin	NN
cord-280549-bsnz24jx	505	15	architecture	architecture	NN
cord-280549-bsnz24jx	505	16	,	,	,
cord-280549-bsnz24jx	505	17	resulting	result	VBG
cord-280549-bsnz24jx	505	18	in	in	IN
cord-280549-bsnz24jx	505	19	G2	G2	NNP
cord-280549-bsnz24jx	505	20	/	/	SYM
cord-280549-bsnz24jx	505	21	M	M	NNP
cord-280549-bsnz24jx	505	22	arrest	arrest	NN
cord-280549-bsnz24jx	505	23	that	that	WDT
cord-280549-bsnz24jx	505	24	is	be	VBZ
cord-280549-bsnz24jx	505	25	dependent	dependent	JJ
cord-280549-bsnz24jx	505	26	on	on	IN
cord-280549-bsnz24jx	505	27	cytoplasmic	cytoplasmic	JJ
cord-280549-bsnz24jx	505	28	compartmentalization	compartmentalization	NN
cord-280549-bsnz24jx	505	29	of	of	IN
cord-280549-bsnz24jx	505	30	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	505	31	,	,	,
cord-280549-bsnz24jx	505	32	cyclin	cyclin	NN
cord-280549-bsnz24jx	505	33	B1	b1	NN
cord-280549-bsnz24jx	505	34	,	,	,
cord-280549-bsnz24jx	505	35	and	and	CC
cord-280549-bsnz24jx	505	36	Wee1	Wee1	NNP
cord-280549-bsnz24jx	505	37	(	(	-LRB-
cord-280549-bsnz24jx	505	38	Peng	Peng	NNP
cord-280549-bsnz24jx	505	39	et	et	NNP
cord-280549-bsnz24jx	505	40	al	al	NNP
cord-280549-bsnz24jx	505	41	.	.	NNP
cord-280549-bsnz24jx	505	42	,	,	,
cord-280549-bsnz24jx	505	43	1997	1997	CD
cord-280549-bsnz24jx	505	44	;	;	.
cord-280549-bsnz24jx	506	1	Laronga	Laronga	NNP
cord-280549-bsnz24jx	506	2	et	et	NNP
cord-280549-bsnz24jx	506	3	al	al	NNP
cord-280549-bsnz24jx	506	4	.	.	.
cord-280549-bsnz24jx	507	1	,	,	,
cord-280549-bsnz24jx	507	2	2000	2000	CD
cord-280549-bsnz24jx	507	3	;	;	:
cord-280549-bsnz24jx	507	4	de	de	NNP
cord-280549-bsnz24jx	507	5	Noronha	Noronha	NNP
cord-280549-bsnz24jx	507	6	et	et	NNP
cord-280549-bsnz24jx	507	7	al	al	NNP
cord-280549-bsnz24jx	507	8	.	.	NNP
cord-280549-bsnz24jx	507	9	,	,	,
cord-280549-bsnz24jx	507	10	2001	2001	CD
cord-280549-bsnz24jx	507	11	;	;	:
cord-280549-bsnz24jx	507	12	Kino	Kino	NNP
cord-280549-bsnz24jx	507	13	et	et	NNP
cord-280549-bsnz24jx	507	14	al	al	NNP
cord-280549-bsnz24jx	507	15	.	.	NNP
cord-280549-bsnz24jx	507	16	,	,	,
cord-280549-bsnz24jx	507	17	2005	2005	CD
cord-280549-bsnz24jx	507	18	)	)	-RRB-
cord-280549-bsnz24jx	507	19	.	.	.
cord-280549-bsnz24jx	508	1	and	and	CC
cord-280549-bsnz24jx	508	2	cyclin	cyclin	NN
cord-280549-bsnz24jx	508	3	B1	b1	NN
cord-280549-bsnz24jx	508	4	,	,	,
cord-280549-bsnz24jx	508	5	a	a	DT
cord-280549-bsnz24jx	508	6	finding	finding	NN
cord-280549-bsnz24jx	508	7	corroborated	corroborate	VBN
cord-280549-bsnz24jx	508	8	by	by	IN
cord-280549-bsnz24jx	508	9	infection	infection	NN
cord-280549-bsnz24jx	508	10	experiments	experiment	NNS
cord-280549-bsnz24jx	508	11	with	with	IN
cord-280549-bsnz24jx	508	12	Vif	vif	NN
cord-280549-bsnz24jx	508	13	-	-	HYPH
cord-280549-bsnz24jx	508	14	deficient	deficient	JJ
cord-280549-bsnz24jx	508	15	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	508	16	virus	virus	NN
cord-280549-bsnz24jx	508	17	that	that	WDT
cord-280549-bsnz24jx	508	18	point	point	VBP
cord-280549-bsnz24jx	508	19	to	to	IN
cord-280549-bsnz24jx	508	20	a	a	DT
cord-280549-bsnz24jx	508	21	role	role	NN
cord-280549-bsnz24jx	508	22	of	of	IN
cord-280549-bsnz24jx	508	23	this	this	DT
cord-280549-bsnz24jx	508	24	viral	viral	JJ
cord-280549-bsnz24jx	508	25	protein	protein	NN
cord-280549-bsnz24jx	508	26	in	in	IN
cord-280549-bsnz24jx	508	27	mediating	mediate	VBG
cord-280549-bsnz24jx	508	28	CDK1	CDK1	NNP
cord-280549-bsnz24jx	508	29	cytoplasmic	cytoplasmic	JJ
cord-280549-bsnz24jx	508	30	-	-	HYPH
cord-280549-bsnz24jx	508	31	retention	retention	NN
cord-280549-bsnz24jx	508	32	(	(	-LRB-
cord-280549-bsnz24jx	508	33	Sakai	Sakai	NNP
cord-280549-bsnz24jx	508	34	et	et	FW
cord-280549-bsnz24jx	508	35	al	al	NNP
cord-280549-bsnz24jx	508	36	.	.	NNP
cord-280549-bsnz24jx	508	37	,	,	,
cord-280549-bsnz24jx	508	38	2011	2011	CD
cord-280549-bsnz24jx	508	39	)	)	-RRB-
cord-280549-bsnz24jx	508	40	.	.	.
cord-280549-bsnz24jx	509	1	HHV-6A	HHV-6A	NNP
cord-280549-bsnz24jx	509	2	and	and	CC
cord-280549-bsnz24jx	509	3	HHV-6B	HHV-6B	NNP
cord-280549-bsnz24jx	509	4	provide	provide	VBP
cord-280549-bsnz24jx	509	5	other	other	JJ
cord-280549-bsnz24jx	509	6	examples	example	NNS
cord-280549-bsnz24jx	509	7	of	of	IN
cord-280549-bsnz24jx	509	8	mislocalization	mislocalization	NN
cord-280549-bsnz24jx	509	9	coupled	couple	VBN
cord-280549-bsnz24jx	509	10	to	to	IN
cord-280549-bsnz24jx	509	11	cell	cell	NN
cord-280549-bsnz24jx	509	12	cycle	cycle	NN
cord-280549-bsnz24jx	509	13	arrest	arrest	NN
cord-280549-bsnz24jx	509	14	,	,	,
cord-280549-bsnz24jx	509	15	as	as	IN
cord-280549-bsnz24jx	509	16	their	-PRON-	PRP$
cord-280549-bsnz24jx	509	17	infection	infection	NN
cord-280549-bsnz24jx	509	18	reduces	reduce	VBZ
cord-280549-bsnz24jx	509	19	E2F1-Rb	E2F1-Rb	NNP
cord-280549-bsnz24jx	509	20	complex	complex	JJ
cord-280549-bsnz24jx	509	21	formation	formation	NN
cord-280549-bsnz24jx	509	22	and	and	CC
cord-280549-bsnz24jx	509	23	leads	lead	VBZ
cord-280549-bsnz24jx	509	24	to	to	IN
cord-280549-bsnz24jx	509	25	accumulation	accumulation	NN
cord-280549-bsnz24jx	509	26	of	of	IN
cord-280549-bsnz24jx	509	27	E2F1	E2F1	NNP
cord-280549-bsnz24jx	509	28	both	both	CC
cord-280549-bsnz24jx	509	29	in	in	IN
cord-280549-bsnz24jx	509	30	the	the	DT
cord-280549-bsnz24jx	509	31	cytoplasmic	cytoplasmic	JJ
cord-280549-bsnz24jx	509	32	and	and	CC
cord-280549-bsnz24jx	509	33	nuclear	nuclear	JJ
cord-280549-bsnz24jx	509	34	fractions	fraction	NNS
cord-280549-bsnz24jx	509	35	,	,	,
cord-280549-bsnz24jx	509	36	as	as	IN
cord-280549-bsnz24jx	509	37	opposed	oppose	VBN
cord-280549-bsnz24jx	509	38	to	to	IN
cord-280549-bsnz24jx	509	39	its	-PRON-	PRP$
cord-280549-bsnz24jx	509	40	strict	strict	JJ
cord-280549-bsnz24jx	509	41	nuclear	nuclear	JJ
cord-280549-bsnz24jx	509	42	localization	localization	NN
cord-280549-bsnz24jx	509	43	in	in	IN
cord-280549-bsnz24jx	509	44	normal	normal	JJ
cord-280549-bsnz24jx	509	45	cells	cell	NNS
cord-280549-bsnz24jx	509	46	(	(	-LRB-
cord-280549-bsnz24jx	509	47	Mlechkovich	Mlechkovich	NNP
cord-280549-bsnz24jx	509	48	and	and	CC
cord-280549-bsnz24jx	509	49	Frenkel	Frenkel	NNP
cord-280549-bsnz24jx	509	50	,	,	,
cord-280549-bsnz24jx	509	51	2007	2007	CD
cord-280549-bsnz24jx	509	52	)	)	-RRB-
cord-280549-bsnz24jx	509	53	.	.	.
cord-280549-bsnz24jx	510	1	Although	although	IN
cord-280549-bsnz24jx	510	2	the	the	DT
cord-280549-bsnz24jx	510	3	relevance	relevance	NN
cord-280549-bsnz24jx	510	4	of	of	IN
cord-280549-bsnz24jx	510	5	E2F1	E2F1	NNP
cord-280549-bsnz24jx	510	6	translocation	translocation	NN
cord-280549-bsnz24jx	510	7	in	in	IN
cord-280549-bsnz24jx	510	8	HHV-6-induced	hhv-6-induced	JJ
cord-280549-bsnz24jx	510	9	cell	cell	NN
cord-280549-bsnz24jx	510	10	cycle	cycle	NN
cord-280549-bsnz24jx	510	11	arrest	arrest	NN
cord-280549-bsnz24jx	510	12	is	be	VBZ
cord-280549-bsnz24jx	510	13	not	not	RB
cord-280549-bsnz24jx	510	14	completely	completely	RB
cord-280549-bsnz24jx	510	15	understood	understand	VBN
cord-280549-bsnz24jx	510	16	,	,	,
cord-280549-bsnz24jx	510	17	it	-PRON-	PRP
cord-280549-bsnz24jx	510	18	illustrates	illustrate	VBZ
cord-280549-bsnz24jx	510	19	that	that	IN
cord-280549-bsnz24jx	510	20	viruses	virus	NNS
cord-280549-bsnz24jx	510	21	could	could	MD
cord-280549-bsnz24jx	510	22	also	also	RB
cord-280549-bsnz24jx	510	23	target	target	VB
cord-280549-bsnz24jx	510	24	E2F	E2F	NNP
cord-280549-bsnz24jx	510	25	family	family	NN
cord-280549-bsnz24jx	510	26	of	of	IN
cord-280549-bsnz24jx	510	27	protein	protein	NN
cord-280549-bsnz24jx	510	28	in	in	IN
cord-280549-bsnz24jx	510	29	this	this	DT
cord-280549-bsnz24jx	510	30	context	context	NN
cord-280549-bsnz24jx	511	1	(	(	-LRB-
cord-280549-bsnz24jx	511	2	Sharon	Sharon	NNP
cord-280549-bsnz24jx	511	3	et	et	NNP
cord-280549-bsnz24jx	511	4	al	al	NNP
cord-280549-bsnz24jx	511	5	.	.	NNP
cord-280549-bsnz24jx	511	6	,	,	,
cord-280549-bsnz24jx	511	7	2014	2014	CD
cord-280549-bsnz24jx	511	8	)	)	-RRB-
cord-280549-bsnz24jx	511	9	.	.	.
cord-280549-bsnz24jx	512	1	Herpesvirus	Herpesvirus	NNP
cord-280549-bsnz24jx	512	2	saimiri	saimiri	NNP
cord-280549-bsnz24jx	512	3	(	(	-LRB-
cord-280549-bsnz24jx	512	4	HVS	HVS	NNP
cord-280549-bsnz24jx	512	5	)	)	-RRB-
cord-280549-bsnz24jx	512	6	,	,	,
cord-280549-bsnz24jx	512	7	a	a	DT
cord-280549-bsnz24jx	512	8	T	T	NNP
cord-280549-bsnz24jx	512	9	-	-	HYPH
cord-280549-bsnz24jx	512	10	lymphotropic	lymphotropic	NNP
cord-280549-bsnz24jx	512	11	gammaherpesvirus	gammaherpesvirus	NNP
cord-280549-bsnz24jx	512	12	that	that	WDT
cord-280549-bsnz24jx	512	13	establishes	establish	VBZ
cord-280549-bsnz24jx	512	14	persistent	persistent	JJ
cord-280549-bsnz24jx	512	15	conditions	condition	NNS
cord-280549-bsnz24jx	512	16	in	in	IN
cord-280549-bsnz24jx	512	17	primate	primate	JJ
cord-280549-bsnz24jx	512	18	host	host	NN
cord-280549-bsnz24jx	512	19	species	specie	NNS
cord-280549-bsnz24jx	512	20	,	,	,
cord-280549-bsnz24jx	512	21	encodes	encode	VBZ
cord-280549-bsnz24jx	512	22	the	the	DT
cord-280549-bsnz24jx	512	23	first	first	JJ
cord-280549-bsnz24jx	512	24	reported	report	VBN
cord-280549-bsnz24jx	512	25	viral	viral	JJ
cord-280549-bsnz24jx	512	26	-	-	HYPH
cord-280549-bsnz24jx	512	27	cyclin	cyclin	NN
cord-280549-bsnz24jx	512	28	(	(	-LRB-
cord-280549-bsnz24jx	512	29	v	v	NN
cord-280549-bsnz24jx	512	30	-	-	HYPH
cord-280549-bsnz24jx	512	31	cyclin	cyclin	NN
cord-280549-bsnz24jx	512	32	)	)	-RRB-
cord-280549-bsnz24jx	513	1	(	(	-LRB-
cord-280549-bsnz24jx	513	2	Nicholas	Nicholas	NNP
cord-280549-bsnz24jx	513	3	et	et	NNP
cord-280549-bsnz24jx	513	4	al	al	NNP
cord-280549-bsnz24jx	513	5	.	.	.
cord-280549-bsnz24jx	514	1	,	,	,
cord-280549-bsnz24jx	514	2	1992	1992	CD
cord-280549-bsnz24jx	514	3	;	;	:
cord-280549-bsnz24jx	514	4	Fickenscher	Fickenscher	NNP
cord-280549-bsnz24jx	514	5	and	and	CC
cord-280549-bsnz24jx	514	6	Fleckenstein	Fleckenstein	NNP
cord-280549-bsnz24jx	514	7	,	,	,
cord-280549-bsnz24jx	514	8	2001	2001	CD
cord-280549-bsnz24jx	514	9	)	)	-RRB-
cord-280549-bsnz24jx	514	10	.	.	.
cord-280549-bsnz24jx	515	1	Similarly	similarly	RB
cord-280549-bsnz24jx	515	2	,	,	,
cord-280549-bsnz24jx	515	3	amino	amino	NN
cord-280549-bsnz24jx	515	4	acid	acid	NN
cord-280549-bsnz24jx	515	5	and	and	CC
cord-280549-bsnz24jx	515	6	DNA	dna	NN
cord-280549-bsnz24jx	515	7	sequence	sequence	NN
cord-280549-bsnz24jx	515	8	analyses	analysis	NNS
cord-280549-bsnz24jx	515	9	of	of	IN
cord-280549-bsnz24jx	515	10	KSHV	KSHV	NNP
cord-280549-bsnz24jx	515	11	,	,	,
cord-280549-bsnz24jx	515	12	which	which	WDT
cord-280549-bsnz24jx	515	13	has	have	VBZ
cord-280549-bsnz24jx	515	14	been	be	VBN
cord-280549-bsnz24jx	515	15	strongly	strongly	RB
cord-280549-bsnz24jx	515	16	implicated	implicate	VBN
cord-280549-bsnz24jx	515	17	as	as	IN
cord-280549-bsnz24jx	515	18	the	the	DT
cord-280549-bsnz24jx	515	19	etiologic	etiologic	JJ
cord-280549-bsnz24jx	515	20	factor	factor	NN
cord-280549-bsnz24jx	515	21	in	in	IN
cord-280549-bsnz24jx	515	22	the	the	DT
cord-280549-bsnz24jx	515	23	development	development	NN
cord-280549-bsnz24jx	515	24	of	of	IN
cord-280549-bsnz24jx	515	25	Kaposi	Kaposi	NNP
cord-280549-bsnz24jx	515	26	's	's	POS
cord-280549-bsnz24jx	515	27	sarcoma	sarcoma	NN
cord-280549-bsnz24jx	515	28	and	and	CC
cord-280549-bsnz24jx	515	29	primary	primary	JJ
cord-280549-bsnz24jx	515	30	effusion	effusion	NN
cord-280549-bsnz24jx	515	31	lymphomas	lymphoma	NNS
cord-280549-bsnz24jx	515	32	(	(	-LRB-
cord-280549-bsnz24jx	515	33	PEL	PEL	NNP
cord-280549-bsnz24jx	515	34	)	)	-RRB-
cord-280549-bsnz24jx	516	1	(	(	-LRB-
cord-280549-bsnz24jx	516	2	Chang	Chang	NNP
cord-280549-bsnz24jx	516	3	et	et	NNP
cord-280549-bsnz24jx	516	4	al	al	NNP
cord-280549-bsnz24jx	516	5	.	.	.
cord-280549-bsnz24jx	517	1	,	,	,
cord-280549-bsnz24jx	517	2	1994	1994	CD
cord-280549-bsnz24jx	517	3	;	;	:
cord-280549-bsnz24jx	517	4	Cesarman	Cesarman	NNP
cord-280549-bsnz24jx	517	5	et	et	NNP
cord-280549-bsnz24jx	517	6	al	al	NNP
cord-280549-bsnz24jx	517	7	.	.	NNP
cord-280549-bsnz24jx	517	8	,	,	,
cord-280549-bsnz24jx	517	9	1995	1995	CD
cord-280549-bsnz24jx	517	10	)	)	-RRB-
cord-280549-bsnz24jx	517	11	,	,	,
cord-280549-bsnz24jx	517	12	identified	identify	VBD
cord-280549-bsnz24jx	517	13	a	a	DT
cord-280549-bsnz24jx	517	14	"	"	``
cord-280549-bsnz24jx	517	15	cyclin	cyclin	NN
cord-280549-bsnz24jx	517	16	-	-	HYPH
cord-280549-bsnz24jx	517	17	box	box	NN
cord-280549-bsnz24jx	517	18	"	"	''
cord-280549-bsnz24jx	517	19	showing	show	VBG
cord-280549-bsnz24jx	517	20	similarity	similarity	NN
cord-280549-bsnz24jx	517	21	to	to	IN
cord-280549-bsnz24jx	517	22	human	human	JJ
cord-280549-bsnz24jx	517	23	cyclin	cyclin	NN
cord-280549-bsnz24jx	517	24	Jung	Jung	NNP
cord-280549-bsnz24jx	517	25	et	et	NNP
cord-280549-bsnz24jx	517	26	al	al	NNP
cord-280549-bsnz24jx	517	27	.	.	NNP
cord-280549-bsnz24jx	517	28	,	,	,
cord-280549-bsnz24jx	517	29	1994	1994	CD
cord-280549-bsnz24jx	517	30	;	;	:
cord-280549-bsnz24jx	517	31	Godden	Godden	NNP
cord-280549-bsnz24jx	517	32	-	-	HYPH
cord-280549-bsnz24jx	517	33	Kent	Kent	NNP
cord-280549-bsnz24jx	517	34	et	et	NNP
cord-280549-bsnz24jx	517	35	al	al	NNP
cord-280549-bsnz24jx	517	36	.	.	NNP
cord-280549-bsnz24jx	517	37	,	,	,
cord-280549-bsnz24jx	517	38	1997	1997	CD
cord-280549-bsnz24jx	517	39	;	;	:
cord-280549-bsnz24jx	517	40	Li	Li	NNP
cord-280549-bsnz24jx	517	41	et	et	NNP
cord-280549-bsnz24jx	517	42	al	al	NNP
cord-280549-bsnz24jx	517	43	.	.	NNP
cord-280549-bsnz24jx	517	44	,	,	,
cord-280549-bsnz24jx	517	45	1997	1997	CD
cord-280549-bsnz24jx	517	46	;	;	:
cord-280549-bsnz24jx	517	47	Swanton	Swanton	NNP
cord-280549-bsnz24jx	517	48	et	et	NNP
cord-280549-bsnz24jx	517	49	al	al	NNP
cord-280549-bsnz24jx	517	50	.	.	NNP
cord-280549-bsnz24jx	517	51	,	,	,
cord-280549-bsnz24jx	517	52	1997	1997	CD
cord-280549-bsnz24jx	517	53	;	;	:
cord-280549-bsnz24jx	517	54	Kaldis	Kaldis	NNP
cord-280549-bsnz24jx	517	55	,	,	,
cord-280549-bsnz24jx	517	56	1999	1999	CD
cord-280549-bsnz24jx	517	57	MHV68	MHV68	NNP
cord-280549-bsnz24jx	517	58	/	/	SYM
cord-280549-bsnz24jx	517	59	dsDNA	dsdna	RB
cord-280549-bsnz24jx	518	1	Viral	viral	JJ
cord-280549-bsnz24jx	518	2	cyclin	cyclin	NN
cord-280549-bsnz24jx	518	3	CDK2	CDK2	NNP
cord-280549-bsnz24jx	518	4	Phosphorylation	Phosphorylation	NNP
cord-280549-bsnz24jx	518	5	of	of	IN
cord-280549-bsnz24jx	518	6	p27	p27	NN
cord-280549-bsnz24jx	518	7	KIP1	KIP1	NNP
cord-280549-bsnz24jx	519	1	to	to	TO
cord-280549-bsnz24jx	519	2	bypass	bypass	VB
cord-280549-bsnz24jx	519	3	G1	G1	NNP
cord-280549-bsnz24jx	519	4	arrest	arrest	NN
cord-280549-bsnz24jx	520	1	Virgin	Virgin	NNP
cord-280549-bsnz24jx	520	2	et	et	NNP
cord-280549-bsnz24jx	520	3	al	al	NNP
cord-280549-bsnz24jx	520	4	.	.	NNP
cord-280549-bsnz24jx	520	5	,	,	,
cord-280549-bsnz24jx	520	6	1997	1997	CD
cord-280549-bsnz24jx	520	7	;	;	.
cord-280549-bsnz24jx	521	1	Card	card	NN
cord-280549-bsnz24jx	521	2	et	et	FW
cord-280549-bsnz24jx	521	3	al	al	NNP
cord-280549-bsnz24jx	521	4	.	.	NNP
cord-280549-bsnz24jx	521	5	,	,	,
cord-280549-bsnz24jx	521	6	2000	2000	CD
cord-280549-bsnz24jx	521	7	KSHV	KSHV	NNP
cord-280549-bsnz24jx	521	8	/	/	SYM
cord-280549-bsnz24jx	521	9	dsDNA	dsdna	RB
cord-280549-bsnz24jx	522	1	Viral	viral	JJ
cord-280549-bsnz24jx	522	2	cyclin	cyclin	NN
cord-280549-bsnz24jx	522	3	p27	p27	NN
cord-280549-bsnz24jx	523	1	KIP1	KIP1	NNP
cord-280549-bsnz24jx	523	2	Phosphorylation	Phosphorylation	NNP
cord-280549-bsnz24jx	523	3	-	-	HYPH
cord-280549-bsnz24jx	523	4	dependent	dependent	JJ
cord-280549-bsnz24jx	523	5	degradation	degradation	NN
cord-280549-bsnz24jx	523	6	,	,	,
cord-280549-bsnz24jx	523	7	cell	cell	NN
cord-280549-bsnz24jx	523	8	cycle	cycle	NN
cord-280549-bsnz24jx	523	9	progression	progression	NN
cord-280549-bsnz24jx	524	1	Vlach	Vlach	NNP
cord-280549-bsnz24jx	524	2	et	et	FW
cord-280549-bsnz24jx	524	3	al	al	NNP
cord-280549-bsnz24jx	524	4	.	.	NNP
cord-280549-bsnz24jx	524	5	,	,	,
cord-280549-bsnz24jx	524	6	1997	1997	CD
cord-280549-bsnz24jx	524	7	;	;	:
cord-280549-bsnz24jx	524	8	Mann	Mann	NNP
cord-280549-bsnz24jx	524	9	et	et	NNP
cord-280549-bsnz24jx	524	10	al	al	NNP
cord-280549-bsnz24jx	524	11	.	.	NNP
cord-280549-bsnz24jx	524	12	,	,	,
cord-280549-bsnz24jx	524	13	1999	1999	CD
cord-280549-bsnz24jx	524	14	;	;	:
cord-280549-bsnz24jx	524	15	Zhi	Zhi	NNP
cord-280549-bsnz24jx	524	16	et	et	FW
cord-280549-bsnz24jx	524	17	al	al	NNP
cord-280549-bsnz24jx	524	18	.	.	.
cord-280549-bsnz24jx	525	1	,	,	,
cord-280549-bsnz24jx	525	2	2015	2015	CD
cord-280549-bsnz24jx	525	3	Autographa	Autographa	NNP
cord-280549-bsnz24jx	525	4	californica	californica	NN
cord-280549-bsnz24jx	525	5	nucleopolyhedrovirus	nucleopolyhedrovirus	JJ
cord-280549-bsnz24jx	525	6	/dsDNA	/dsDNA	.
cord-280549-bsnz24jx	525	7	IE2	ie2	NN
cord-280549-bsnz24jx	525	8	,	,	,
cord-280549-bsnz24jx	525	9	occlusion	occlusion	NN
cord-280549-bsnz24jx	525	10	-	-	HYPH
cord-280549-bsnz24jx	525	11	derived	derive	VBN
cord-280549-bsnz24jx	525	12	viral	viral	JJ
cord-280549-bsnz24jx	525	13	form	form	NN
cord-280549-bsnz24jx	525	14	-	-	:
cord-280549-bsnz24jx	525	15	EC27	EC27	NNP
cord-280549-bsnz24jx	525	16	CDK6	CDK6	NNP
cord-280549-bsnz24jx	525	17	,	,	,
cord-280549-bsnz24jx	526	1	CDK1	CDK1	NNP
cord-280549-bsnz24jx	526	2	Rb	Rb	NNP
cord-280549-bsnz24jx	526	3	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	526	4	,	,	,
cord-280549-bsnz24jx	526	5	G2	G2	NNP
cord-280549-bsnz24jx	526	6	/	/	SYM
cord-280549-bsnz24jx	526	7	M	M	NNP
cord-280549-bsnz24jx	526	8	cell	cell	NN
cord-280549-bsnz24jx	526	9	cycle	cycle	NN
cord-280549-bsnz24jx	526	10	arrest	arrest	NN
cord-280549-bsnz24jx	526	11	Belyavskyi	Belyavskyi	NNP
cord-280549-bsnz24jx	526	12	et	et	NNP
cord-280549-bsnz24jx	526	13	al	al	NNP
cord-280549-bsnz24jx	526	14	.	.	NNP
cord-280549-bsnz24jx	526	15	,	,	,
cord-280549-bsnz24jx	526	16	1998	1998	CD
cord-280549-bsnz24jx	526	17	;	;	:
cord-280549-bsnz24jx	527	1	Braunagel	Braunagel	NNP
cord-280549-bsnz24jx	527	2	et	et	NNP
cord-280549-bsnz24jx	527	3	al	al	NNP
cord-280549-bsnz24jx	527	4	.	.	NNP
cord-280549-bsnz24jx	527	5	,	,	,
cord-280549-bsnz24jx	527	6	1998	1998	CD
cord-280549-bsnz24jx	527	7	;	;	:
cord-280549-bsnz24jx	528	1	Prikhod'ko	Prikhod'ko	NNP
cord-280549-bsnz24jx	528	2	and	and	CC
cord-280549-bsnz24jx	528	3	Miller	Miller	NNP
cord-280549-bsnz24jx	528	4	,	,	,
cord-280549-bsnz24jx	528	5	1998	1998	CD
cord-280549-bsnz24jx	528	6	Walleye	Walleye	NNP
cord-280549-bsnz24jx	528	7	(	(	-LRB-
cord-280549-bsnz24jx	528	8	Nicholas	Nicholas	NNP
cord-280549-bsnz24jx	528	9	et	et	NNP
cord-280549-bsnz24jx	528	10	al	al	NNP
cord-280549-bsnz24jx	528	11	.	.	NNP
cord-280549-bsnz24jx	528	12	,	,	,
cord-280549-bsnz24jx	528	13	1992	1992	CD
cord-280549-bsnz24jx	528	14	;	;	:
cord-280549-bsnz24jx	528	15	Chang	Chang	NNP
cord-280549-bsnz24jx	528	16	et	et	NNP
cord-280549-bsnz24jx	528	17	al	al	NNP
cord-280549-bsnz24jx	528	18	.	.	NNP
cord-280549-bsnz24jx	528	19	,	,	,
cord-280549-bsnz24jx	528	20	1994	1994	CD
cord-280549-bsnz24jx	529	1	Chang	Chang	NNP
cord-280549-bsnz24jx	529	2	et	et	NNP
cord-280549-bsnz24jx	529	3	al	al	NNP
cord-280549-bsnz24jx	529	4	.	.	.
cord-280549-bsnz24jx	530	1	,	,	,
cord-280549-bsnz24jx	530	2	,	,	,
cord-280549-bsnz24jx	530	3	1996	1996	CD
cord-280549-bsnz24jx	530	4	Cesarman	Cesarman	NNP
cord-280549-bsnz24jx	530	5	et	et	NNP
cord-280549-bsnz24jx	530	6	al	al	NNP
cord-280549-bsnz24jx	530	7	.	.	NNP
cord-280549-bsnz24jx	530	8	,	,	,
cord-280549-bsnz24jx	530	9	1995	1995	CD
cord-280549-bsnz24jx	530	10	;	;	:
cord-280549-bsnz24jx	530	11	Li	Li	NNP
cord-280549-bsnz24jx	530	12	et	et	NNP
cord-280549-bsnz24jx	530	13	al	al	NNP
cord-280549-bsnz24jx	530	14	.	.	NNP
cord-280549-bsnz24jx	530	15	,	,	,
cord-280549-bsnz24jx	530	16	1997	1997	CD
cord-280549-bsnz24jx	531	1	;	;	:
cord-280549-bsnz24jx	531	2	Virgin	Virgin	NNP
cord-280549-bsnz24jx	531	3	et	et	FW
cord-280549-bsnz24jx	531	4	al	al	NNP
cord-280549-bsnz24jx	531	5	.	.	NNP
cord-280549-bsnz24jx	531	6	,	,	,
cord-280549-bsnz24jx	531	7	1997	1997	CD
cord-280549-bsnz24jx	531	8	;	;	.
cord-280549-bsnz24jx	532	1	Fickenscher	Fickenscher	NNP
cord-280549-bsnz24jx	532	2	and	and	CC
cord-280549-bsnz24jx	532	3	Fleckenstein	Fleckenstein	NNP
cord-280549-bsnz24jx	532	4	,	,	,
cord-280549-bsnz24jx	532	5	2001	2001	CD
cord-280549-bsnz24jx	532	6	)	)	-RRB-
cord-280549-bsnz24jx	532	7	that	that	WDT
cord-280549-bsnz24jx	532	8	display	display	VBP
cord-280549-bsnz24jx	532	9	strong	strong	JJ
cord-280549-bsnz24jx	532	10	association	association	NN
cord-280549-bsnz24jx	532	11	with	with	IN
cord-280549-bsnz24jx	532	12	CDK6	CDK6	NNP
cord-280549-bsnz24jx	532	13	,	,	,
cord-280549-bsnz24jx	532	14	leading	lead	VBG
cord-280549-bsnz24jx	532	15	to	to	IN
cord-280549-bsnz24jx	532	16	the	the	DT
cord-280549-bsnz24jx	532	17	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	532	18	of	of	IN
cord-280549-bsnz24jx	532	19	Rb	Rb	NNP
cord-280549-bsnz24jx	532	20	and	and	CC
cord-280549-bsnz24jx	532	21	histone	histone	NN
cord-280549-bsnz24jx	532	22	H1	h1	NN
cord-280549-bsnz24jx	532	23	.	.	.
cord-280549-bsnz24jx	533	1	(	(	-LRB-
cord-280549-bsnz24jx	533	2	Bi	Bi	NNP
cord-280549-bsnz24jx	533	3	)	)	-RRB-
cord-280549-bsnz24jx	533	4	V	v	NN
cord-280549-bsnz24jx	533	5	-	-	HYPH
cord-280549-bsnz24jx	533	6	cyclin	cyclin	NN
cord-280549-bsnz24jx	533	7	-	-	HYPH
cord-280549-bsnz24jx	533	8	CDK	CDK	NNP
cord-280549-bsnz24jx	533	9	complexes	complex	NNS
cord-280549-bsnz24jx	533	10	are	be	VBP
cord-280549-bsnz24jx	533	11	significantly	significantly	RB
cord-280549-bsnz24jx	533	12	more	more	RBR
cord-280549-bsnz24jx	533	13	resistant	resistant	JJ
cord-280549-bsnz24jx	533	14	to	to	IN
cord-280549-bsnz24jx	533	15	the	the	DT
cord-280549-bsnz24jx	533	16	inhibition	inhibition	NN
cord-280549-bsnz24jx	533	17	imposed	impose	VBN
cord-280549-bsnz24jx	533	18	by	by	IN
cord-280549-bsnz24jx	533	19	p21	p21	NN
cord-280549-bsnz24jx	533	20	WAF1	WAF1	NNP
cord-280549-bsnz24jx	533	21	/	/	SYM
cord-280549-bsnz24jx	533	22	CIP1	CIP1	NNP
cord-280549-bsnz24jx	533	23	,	,	,
cord-280549-bsnz24jx	533	24	p27	p27	NNP
cord-280549-bsnz24jx	533	25	KIP1	KIP1	NNP
cord-280549-bsnz24jx	533	26	,	,	,
cord-280549-bsnz24jx	533	27	and	and	CC
cord-280549-bsnz24jx	533	28	p16	p16	NN
cord-280549-bsnz24jx	533	29	INK4A	INK4A	NNS
cord-280549-bsnz24jx	533	30	than	than	IN
cord-280549-bsnz24jx	533	31	cyclin	cyclin	NN
cord-280549-bsnz24jx	533	32	D1-CDK	D1-CDK	NNP
cord-280549-bsnz24jx	533	33	complexes	complex	NNS
cord-280549-bsnz24jx	533	34	in	in	IN
cord-280549-bsnz24jx	533	35	vitro	vitro	FW
cord-280549-bsnz24jx	533	36	(	(	-LRB-
cord-280549-bsnz24jx	533	37	Swanton	Swanton	NNP
cord-280549-bsnz24jx	533	38	et	et	NNP
cord-280549-bsnz24jx	533	39	al	al	NNP
cord-280549-bsnz24jx	533	40	.	.	NNP
cord-280549-bsnz24jx	533	41	,	,	,
cord-280549-bsnz24jx	533	42	1997	1997	CD
cord-280549-bsnz24jx	533	43	)	)	-RRB-
cord-280549-bsnz24jx	533	44	.	.	.
cord-280549-bsnz24jx	534	1	Failure	failure	NN
cord-280549-bsnz24jx	534	2	or	or	CC
cord-280549-bsnz24jx	534	3	weak	weak	JJ
cord-280549-bsnz24jx	534	4	association	association	NN
cord-280549-bsnz24jx	534	5	of	of	IN
cord-280549-bsnz24jx	534	6	p21	p21	NNP
cord-280549-bsnz24jx	534	7	WAF1	WAF1	NNP
cord-280549-bsnz24jx	534	8	/	/	SYM
cord-280549-bsnz24jx	534	9	CIP1	CIP1	NNP
cord-280549-bsnz24jx	534	10	and	and	CC
cord-280549-bsnz24jx	534	11	p27	p27	NN
cord-280549-bsnz24jx	534	12	KIP1	KIP1	NNP
cord-280549-bsnz24jx	534	13	with	with	IN
cord-280549-bsnz24jx	534	14	v	v	NN
cord-280549-bsnz24jx	534	15	-	-	HYPH
cord-280549-bsnz24jx	534	16	cyclin	cyclin	NN
cord-280549-bsnz24jx	534	17	likely	likely	RB
cord-280549-bsnz24jx	534	18	defines	define	VBZ
cord-280549-bsnz24jx	534	19	the	the	DT
cord-280549-bsnz24jx	534	20	inefficiency	inefficiency	NN
cord-280549-bsnz24jx	534	21	of	of	IN
cord-280549-bsnz24jx	534	22	these	these	DT
cord-280549-bsnz24jx	534	23	CKI	CKI	NNP
cord-280549-bsnz24jx	534	24	to	to	TO
cord-280549-bsnz24jx	534	25	inhibit	inhibit	VB
cord-280549-bsnz24jx	534	26	them	-PRON-	PRP
cord-280549-bsnz24jx	535	1	(	(	-LRB-
cord-280549-bsnz24jx	535	2	Swanton	Swanton	NNP
cord-280549-bsnz24jx	535	3	et	et	NNP
cord-280549-bsnz24jx	535	4	al	al	NNP
cord-280549-bsnz24jx	535	5	.	.	.
cord-280549-bsnz24jx	536	1	,	,	,
cord-280549-bsnz24jx	536	2	1997	1997	CD
cord-280549-bsnz24jx	536	3	;	;	:
cord-280549-bsnz24jx	536	4	Schulze	Schulze	NNP
cord-280549-bsnz24jx	536	5	-	-	HYPH
cord-280549-bsnz24jx	536	6	Gahmen	Gahmen	NNP
cord-280549-bsnz24jx	536	7	et	et	FW
cord-280549-bsnz24jx	536	8	al	al	NNP
cord-280549-bsnz24jx	536	9	.	.	.
cord-280549-bsnz24jx	537	1	,	,	,
cord-280549-bsnz24jx	537	2	1999	1999	CD
cord-280549-bsnz24jx	537	3	;	;	:
cord-280549-bsnz24jx	537	4	Card	card	NN
cord-280549-bsnz24jx	537	5	et	et	FW
cord-280549-bsnz24jx	537	6	al	al	NNP
cord-280549-bsnz24jx	537	7	.	.	.
cord-280549-bsnz24jx	538	1	,	,	,
cord-280549-bsnz24jx	538	2	2000	2000	CD
cord-280549-bsnz24jx	538	3	)	)	-RRB-
cord-280549-bsnz24jx	538	4	.	.	.
cord-280549-bsnz24jx	539	1	(	(	-LRB-
cord-280549-bsnz24jx	539	2	Bii	Bii	NNP
cord-280549-bsnz24jx	539	3	)	)	-RRB-
cord-280549-bsnz24jx	539	4	Higher	high	JJR
cord-280549-bsnz24jx	539	5	affinity	affinity	NN
cord-280549-bsnz24jx	539	6	of	of	IN
cord-280549-bsnz24jx	539	7	v	v	NN
cord-280549-bsnz24jx	539	8	-	-	NN
cord-280549-bsnz24jx	539	9	cyclin	cyclin	NN
cord-280549-bsnz24jx	539	10	for	for	IN
cord-280549-bsnz24jx	539	11	CDK6	CDK6	NNP
cord-280549-bsnz24jx	539	12	than	than	IN
cord-280549-bsnz24jx	539	13	p16	p16	NN
cord-280549-bsnz24jx	539	14	INK4A	INK4A	NNS
cord-280549-bsnz24jx	539	15	may	may	MD
cord-280549-bsnz24jx	539	16	prevent	prevent	VB
cord-280549-bsnz24jx	539	17	its	-PRON-	PRP$
cord-280549-bsnz24jx	539	18	displacement	displacement	NN
cord-280549-bsnz24jx	539	19	by	by	IN
cord-280549-bsnz24jx	539	20	p16	p16	NN
cord-280549-bsnz24jx	539	21	INK4A	INK4A	NNS
cord-280549-bsnz24jx	539	22	.	.	.
cord-280549-bsnz24jx	540	1	(	(	-LRB-
cord-280549-bsnz24jx	540	2	C	C	NNP
cord-280549-bsnz24jx	540	3	)	)	-RRB-
cord-280549-bsnz24jx	541	1	Both	both	DT
cord-280549-bsnz24jx	541	2	crocodile	crocodile	NN
cord-280549-bsnz24jx	541	3	and	and	CC
cord-280549-bsnz24jx	541	4	squirrel	squirrel	NN
cord-280549-bsnz24jx	541	5	poxviruses	poxvirus	NNS
cord-280549-bsnz24jx	541	6	encode	encode	VBP
cord-280549-bsnz24jx	541	7	the	the	DT
cord-280549-bsnz24jx	541	8	APC	APC	NNP
cord-280549-bsnz24jx	541	9	/	/	SYM
cord-280549-bsnz24jx	541	10	cyclosome	cyclosome	NN
cord-280549-bsnz24jx	541	11	regulator	regulator	NN
cord-280549-bsnz24jx	541	12	(	(	-LRB-
cord-280549-bsnz24jx	541	13	PACR	PACR	NNP
cord-280549-bsnz24jx	541	14	)	)	-RRB-
cord-280549-bsnz24jx	541	15	,	,	,
cord-280549-bsnz24jx	541	16	which	which	WDT
cord-280549-bsnz24jx	541	17	shares	share	VBZ
cord-280549-bsnz24jx	541	18	sequence	sequence	NN
cord-280549-bsnz24jx	541	19	similarities	similarity	NNS
cord-280549-bsnz24jx	541	20	to	to	IN
cord-280549-bsnz24jx	541	21	the	the	DT
cord-280549-bsnz24jx	541	22	APC	APC	NNP
cord-280549-bsnz24jx	541	23	subunit	subunit	NN
cord-280549-bsnz24jx	541	24	11	11	CD
cord-280549-bsnz24jx	541	25	(	(	-LRB-
cord-280549-bsnz24jx	541	26	APC11	APC11	NNP
cord-280549-bsnz24jx	541	27	)	)	-RRB-
cord-280549-bsnz24jx	541	28	.	.	.
cord-280549-bsnz24jx	542	1	PACR	PACR	NNP
cord-280549-bsnz24jx	542	2	mimics	mimic	VBZ
cord-280549-bsnz24jx	542	3	the	the	DT
cord-280549-bsnz24jx	542	4	binding	binding	JJ
cord-280549-bsnz24jx	542	5	ability	ability	NN
cord-280549-bsnz24jx	542	6	of	of	IN
cord-280549-bsnz24jx	542	7	APC11	APC11	NNP
cord-280549-bsnz24jx	542	8	to	to	IN
cord-280549-bsnz24jx	542	9	APC2	apc2	NN
cord-280549-bsnz24jx	543	1	but	but	CC
cord-280549-bsnz24jx	543	2	not	not	RB
cord-280549-bsnz24jx	543	3	the	the	DT
cord-280549-bsnz24jx	543	4	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	543	5	ligase	ligase	NN
cord-280549-bsnz24jx	543	6	activity	activity	NN
cord-280549-bsnz24jx	543	7	of	of	IN
cord-280549-bsnz24jx	543	8	APC11	APC11	NNP
cord-280549-bsnz24jx	543	9	.	.	.
cord-280549-bsnz24jx	544	1	Thus	thus	RB
cord-280549-bsnz24jx	544	2	,	,	,
cord-280549-bsnz24jx	544	3	poxvirus	poxvirus	NNP
cord-280549-bsnz24jx	544	4	hinders	hinder	VBZ
cord-280549-bsnz24jx	544	5	normal	normal	JJ
cord-280549-bsnz24jx	544	6	cell	cell	NN
cord-280549-bsnz24jx	544	7	cycle	cycle	NN
cord-280549-bsnz24jx	544	8	progression	progression	NN
cord-280549-bsnz24jx	544	9	by	by	IN
cord-280549-bsnz24jx	544	10	encoding	encode	VBG
cord-280549-bsnz24jx	544	11	an	an	DT
cord-280549-bsnz24jx	544	12	inactive	inactive	JJ
cord-280549-bsnz24jx	544	13	homolog	homolog	NN
cord-280549-bsnz24jx	544	14	of	of	IN
cord-280549-bsnz24jx	544	15	APC11	APC11	NNP
cord-280549-bsnz24jx	545	1	(	(	-LRB-
cord-280549-bsnz24jx	545	2	Mo	Mo	NNP
cord-280549-bsnz24jx	545	3	et	et	NNP
cord-280549-bsnz24jx	545	4	al	al	NNP
cord-280549-bsnz24jx	545	5	.	.	NNP
cord-280549-bsnz24jx	545	6	,	,	,
cord-280549-bsnz24jx	545	7	2009	2009	CD
cord-280549-bsnz24jx	545	8	)	)	-RRB-
cord-280549-bsnz24jx	545	9	.	.	.
cord-280549-bsnz24jx	546	1	D2	D2	NNP
cord-280549-bsnz24jx	546	2	(	(	-LRB-
cord-280549-bsnz24jx	546	3	Chang	Chang	NNP
cord-280549-bsnz24jx	546	4	et	et	NNP
cord-280549-bsnz24jx	546	5	al	al	NNP
cord-280549-bsnz24jx	546	6	.	.	NNP
cord-280549-bsnz24jx	546	7	,	,	,
cord-280549-bsnz24jx	546	8	1996	1996	CD
cord-280549-bsnz24jx	546	9	;	;	:
cord-280549-bsnz24jx	546	10	Li	Li	NNP
cord-280549-bsnz24jx	546	11	et	et	NNP
cord-280549-bsnz24jx	546	12	al	al	NNP
cord-280549-bsnz24jx	546	13	.	.	NNP
cord-280549-bsnz24jx	546	14	,	,	,
cord-280549-bsnz24jx	546	15	1997	1997	CD
cord-280549-bsnz24jx	546	16	)	)	-RRB-
cord-280549-bsnz24jx	546	17	.	.	.
cord-280549-bsnz24jx	547	1	In	in	IN
cord-280549-bsnz24jx	547	2	addition	addition	NN
cord-280549-bsnz24jx	547	3	,	,	,
cord-280549-bsnz24jx	547	4	murine	murine	JJ
cord-280549-bsnz24jx	547	5	gammaherpesvirus	gammaherpesvirus	NNP
cord-280549-bsnz24jx	547	6	68	68	CD
cord-280549-bsnz24jx	547	7	(	(	-LRB-
cord-280549-bsnz24jx	547	8	MHV68	MHV68	NNP
cord-280549-bsnz24jx	547	9	)	)	-RRB-
cord-280549-bsnz24jx	547	10	,	,	,
cord-280549-bsnz24jx	547	11	another	another	DT
cord-280549-bsnz24jx	547	12	member	member	NN
cord-280549-bsnz24jx	547	13	of	of	IN
cord-280549-bsnz24jx	547	14	the	the	DT
cord-280549-bsnz24jx	547	15	gammaherpesviruses	gammaherpesviruses	NNPS
cord-280549-bsnz24jx	547	16	,	,	,
cord-280549-bsnz24jx	547	17	shares	share	NNS
cord-280549-bsnz24jx	547	18	with	with	IN
cord-280549-bsnz24jx	547	19	HVS	HVS	NNP
cord-280549-bsnz24jx	547	20	and	and	CC
cord-280549-bsnz24jx	547	21	KSHV	KSHV	NNP
cord-280549-bsnz24jx	547	22	similarities	similarity	NNS
cord-280549-bsnz24jx	547	23	in	in	IN
cord-280549-bsnz24jx	547	24	the	the	DT
cord-280549-bsnz24jx	547	25	sequence	sequence	NN
cord-280549-bsnz24jx	547	26	of	of	IN
cord-280549-bsnz24jx	547	27	an	an	DT
cord-280549-bsnz24jx	547	28	open	open	JJ
cord-280549-bsnz24jx	547	29	reading	reading	NN
cord-280549-bsnz24jx	547	30	frame	frame	NN
cord-280549-bsnz24jx	547	31	that	that	WDT
cord-280549-bsnz24jx	547	32	is	be	VBZ
cord-280549-bsnz24jx	547	33	predicted	predict	VBN
cord-280549-bsnz24jx	547	34	to	to	TO
cord-280549-bsnz24jx	547	35	encode	encode	VB
cord-280549-bsnz24jx	547	36	a	a	DT
cord-280549-bsnz24jx	547	37	D	d	NN
cord-280549-bsnz24jx	547	38	-	-	HYPH
cord-280549-bsnz24jx	547	39	type	type	NN
cord-280549-bsnz24jx	547	40	cyclin	cyclin	NN
cord-280549-bsnz24jx	547	41	(	(	-LRB-
cord-280549-bsnz24jx	547	42	Virgin	Virgin	NNP
cord-280549-bsnz24jx	547	43	et	et	FW
cord-280549-bsnz24jx	547	44	al	al	NNP
cord-280549-bsnz24jx	547	45	.	.	NNP
cord-280549-bsnz24jx	547	46	,	,	,
cord-280549-bsnz24jx	547	47	1997	1997	CD
cord-280549-bsnz24jx	547	48	)	)	-RRB-
cord-280549-bsnz24jx	547	49	.	.	.
cord-280549-bsnz24jx	548	1	Taken	take	VBN
cord-280549-bsnz24jx	548	2	together	together	RB
cord-280549-bsnz24jx	548	3	,	,	,
cord-280549-bsnz24jx	548	4	these	these	DT
cord-280549-bsnz24jx	548	5	findings	finding	NNS
cord-280549-bsnz24jx	548	6	argue	argue	VBP
cord-280549-bsnz24jx	548	7	for	for	IN
cord-280549-bsnz24jx	548	8	a	a	DT
cord-280549-bsnz24jx	548	9	conserved	conserved	JJ
cord-280549-bsnz24jx	548	10	role	role	NN
cord-280549-bsnz24jx	548	11	of	of	IN
cord-280549-bsnz24jx	548	12	these	these	DT
cord-280549-bsnz24jx	548	13	v	v	NN
cord-280549-bsnz24jx	548	14	-	-	HYPH
cord-280549-bsnz24jx	548	15	cyclins	cyclin	NNS
cord-280549-bsnz24jx	548	16	in	in	IN
cord-280549-bsnz24jx	548	17	gammaherpesvirus	gammaherpesvirus	NNP
cord-280549-bsnz24jx	548	18	biology	biology	NN
cord-280549-bsnz24jx	548	19	.	.	.
cord-280549-bsnz24jx	549	1	Indeed	indeed	RB
cord-280549-bsnz24jx	549	2	,	,	,
cord-280549-bsnz24jx	549	3	both	both	CC
cord-280549-bsnz24jx	549	4	HVS	HVS	NNP
cord-280549-bsnz24jx	549	5	and	and	CC
cord-280549-bsnz24jx	549	6	KSHV	KSHV	NNP
cord-280549-bsnz24jx	549	7	v	v	NNP
cord-280549-bsnz24jx	549	8	-	-	HYPH
cord-280549-bsnz24jx	549	9	cyclins	cyclin	NNS
cord-280549-bsnz24jx	549	10	show	show	VBP
cord-280549-bsnz24jx	549	11	strong	strong	JJ
cord-280549-bsnz24jx	549	12	association	association	NN
cord-280549-bsnz24jx	549	13	with	with	IN
cord-280549-bsnz24jx	549	14	CDK6	CDK6	NNP
cord-280549-bsnz24jx	549	15	,	,	,
cord-280549-bsnz24jx	549	16	leading	lead	VBG
cord-280549-bsnz24jx	549	17	to	to	IN
cord-280549-bsnz24jx	549	18	the	the	DT
cord-280549-bsnz24jx	549	19	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	549	20	of	of	IN
cord-280549-bsnz24jx	549	21	Rb	Rb	NNP
cord-280549-bsnz24jx	549	22	and	and	CC
cord-280549-bsnz24jx	549	23	histone	histone	NN
cord-280549-bsnz24jx	549	24	H1	h1	NN
cord-280549-bsnz24jx	549	25	(	(	-LRB-
cord-280549-bsnz24jx	549	26	Jung	Jung	NNP
cord-280549-bsnz24jx	549	27	et	et	NNP
cord-280549-bsnz24jx	549	28	al	al	NNP
cord-280549-bsnz24jx	549	29	.	.	NNP
cord-280549-bsnz24jx	549	30	,	,	,
cord-280549-bsnz24jx	549	31	1994	1994	CD
cord-280549-bsnz24jx	549	32	;	;	:
cord-280549-bsnz24jx	549	33	Li	Li	NNP
cord-280549-bsnz24jx	549	34	et	et	NNP
cord-280549-bsnz24jx	549	35	al	al	NNP
cord-280549-bsnz24jx	549	36	.	.	NNP
cord-280549-bsnz24jx	549	37	,	,	,
cord-280549-bsnz24jx	549	38	1997	1997	CD
cord-280549-bsnz24jx	549	39	)	)	-RRB-
cord-280549-bsnz24jx	549	40	.	.	.
cord-280549-bsnz24jx	550	1	Surprisingly	surprisingly	RB
cord-280549-bsnz24jx	550	2	,	,	,
cord-280549-bsnz24jx	550	3	despite	despite	IN
cord-280549-bsnz24jx	550	4	the	the	DT
cord-280549-bsnz24jx	550	5	fact	fact	NN
cord-280549-bsnz24jx	550	6	that	that	IN
cord-280549-bsnz24jx	550	7	v	v	NN
cord-280549-bsnz24jx	550	8	-	-	HYPH
cord-280549-bsnz24jx	550	9	cyclin	cyclin	NN
cord-280549-bsnz24jx	550	10	of	of	IN
cord-280549-bsnz24jx	550	11	MHV68	MHV68	NNP
cord-280549-bsnz24jx	550	12	displays	display	NNS
cord-280549-bsnz24jx	550	13	only	only	RB
cord-280549-bsnz24jx	550	14	around	around	IN
cord-280549-bsnz24jx	550	15	20	20	CD
cord-280549-bsnz24jx	550	16	%	%	NN
cord-280549-bsnz24jx	550	17	similarity	similarity	NN
cord-280549-bsnz24jx	550	18	to	to	TO
cord-280549-bsnz24jx	550	19	cyclin	cyclin	VB
cord-280549-bsnz24jx	550	20	A	A	NNP
cord-280549-bsnz24jx	550	21	/	/	SYM
cord-280549-bsnz24jx	550	22	E	e	NN
cord-280549-bsnz24jx	550	23	,	,	,
cord-280549-bsnz24jx	550	24	it	-PRON-	PRP
cord-280549-bsnz24jx	550	25	associates	associate	VBZ
cord-280549-bsnz24jx	550	26	with	with	IN
cord-280549-bsnz24jx	550	27	CDK2	CDK2	NNP
cord-280549-bsnz24jx	550	28	rather	rather	RB
cord-280549-bsnz24jx	550	29	than	than	IN
cord-280549-bsnz24jx	550	30	CDK6	CDK6	NNP
cord-280549-bsnz24jx	551	1	(	(	-LRB-
cord-280549-bsnz24jx	551	2	Card	card	NN
cord-280549-bsnz24jx	551	3	et	et	FW
cord-280549-bsnz24jx	551	4	al	al	NNP
cord-280549-bsnz24jx	551	5	.	.	NNP
cord-280549-bsnz24jx	551	6	,	,	,
cord-280549-bsnz24jx	551	7	2000	2000	CD
cord-280549-bsnz24jx	551	8	)	)	-RRB-
cord-280549-bsnz24jx	551	9	.	.	.
cord-280549-bsnz24jx	552	1	Herpesvirus	Herpesvirus	NNP
cord-280549-bsnz24jx	552	2	ateles	atele	NNS
cord-280549-bsnz24jx	552	3	(	(	-LRB-
cord-280549-bsnz24jx	552	4	AtHV-2	athv-2	NN
cord-280549-bsnz24jx	552	5	)	)	-RRB-
cord-280549-bsnz24jx	552	6	causes	cause	VBZ
cord-280549-bsnz24jx	552	7	lethal	lethal	JJ
cord-280549-bsnz24jx	552	8	lymphomas	lymphoma	NNS
cord-280549-bsnz24jx	552	9	in	in	IN
cord-280549-bsnz24jx	552	10	various	various	JJ
cord-280549-bsnz24jx	552	11	new	new	JJ
cord-280549-bsnz24jx	552	12	world	world	NN
cord-280549-bsnz24jx	552	13	primates	primate	NNS
cord-280549-bsnz24jx	552	14	and	and	CC
cord-280549-bsnz24jx	552	15	is	be	VBZ
cord-280549-bsnz24jx	552	16	closely	closely	RB
cord-280549-bsnz24jx	552	17	related	related	JJ
cord-280549-bsnz24jx	552	18	to	to	IN
cord-280549-bsnz24jx	552	19	HVS	HVS	NNP
cord-280549-bsnz24jx	552	20	.	.	.
cord-280549-bsnz24jx	553	1	The	the	DT
cord-280549-bsnz24jx	553	2	light	light	JJ
cord-280549-bsnz24jx	553	3	DNA	dna	NN
cord-280549-bsnz24jx	553	4	segment	segment	NN
cord-280549-bsnz24jx	553	5	of	of	IN
cord-280549-bsnz24jx	553	6	AtHV-2	AtHV-2	,
cord-280549-bsnz24jx	553	7	possesses	possess	VBZ
cord-280549-bsnz24jx	553	8	an	an	DT
cord-280549-bsnz24jx	553	9	open	open	JJ
cord-280549-bsnz24jx	553	10	reading	reading	NN
cord-280549-bsnz24jx	553	11	frame	frame	NN
cord-280549-bsnz24jx	553	12	which	which	WDT
cord-280549-bsnz24jx	553	13	shows	show	VBZ
cord-280549-bsnz24jx	553	14	significant	significant	JJ
cord-280549-bsnz24jx	553	15	homology	homology	NN
cord-280549-bsnz24jx	553	16	to	to	IN
cord-280549-bsnz24jx	553	17	D	d	NN
cord-280549-bsnz24jx	553	18	-	-	HYPH
cord-280549-bsnz24jx	553	19	type	type	NN
cord-280549-bsnz24jx	553	20	cyclins	cyclin	NNS
cord-280549-bsnz24jx	553	21	although	although	IN
cord-280549-bsnz24jx	553	22	its	-PRON-	PRP$
cord-280549-bsnz24jx	553	23	function	function	NN
cord-280549-bsnz24jx	553	24	was	be	VBD
cord-280549-bsnz24jx	553	25	not	not	RB
cord-280549-bsnz24jx	553	26	studied	study	VBN
cord-280549-bsnz24jx	553	27	in	in	IN
cord-280549-bsnz24jx	553	28	molecular	molecular	JJ
cord-280549-bsnz24jx	553	29	terms	term	NNS
cord-280549-bsnz24jx	553	30	(	(	-LRB-
cord-280549-bsnz24jx	553	31	Albrecht	Albrecht	NNP
cord-280549-bsnz24jx	553	32	,	,	,
cord-280549-bsnz24jx	553	33	2000	2000	CD
cord-280549-bsnz24jx	553	34	)	)	-RRB-
cord-280549-bsnz24jx	553	35	.	.	.
cord-280549-bsnz24jx	554	1	Interestingly	interestingly	RB
cord-280549-bsnz24jx	554	2	,	,	,
cord-280549-bsnz24jx	554	3	unlike	unlike	IN
cord-280549-bsnz24jx	554	4	D	d	NN
cord-280549-bsnz24jx	554	5	-	-	HYPH
cord-280549-bsnz24jx	554	6	type	type	NN
cord-280549-bsnz24jx	554	7	cyclins	cyclin	NNS
cord-280549-bsnz24jx	554	8	that	that	WDT
cord-280549-bsnz24jx	554	9	have	have	VBP
cord-280549-bsnz24jx	554	10	broad	broad	JJ
cord-280549-bsnz24jx	554	11	association	association	NN
cord-280549-bsnz24jx	554	12	with	with	IN
cord-280549-bsnz24jx	554	13	different	different	JJ
cord-280549-bsnz24jx	554	14	CDKs	cdk	NNS
cord-280549-bsnz24jx	554	15	,	,	,
cord-280549-bsnz24jx	554	16	the	the	DT
cord-280549-bsnz24jx	554	17	v	v	NN
cord-280549-bsnz24jx	554	18	-	-	HYPH
cord-280549-bsnz24jx	554	19	cyclins	cyclin	NNS
cord-280549-bsnz24jx	554	20	of	of	IN
cord-280549-bsnz24jx	554	21	HVS	HVS	NNP
cord-280549-bsnz24jx	554	22	and	and	CC
cord-280549-bsnz24jx	554	23	KSHV	KSHV	NNP
cord-280549-bsnz24jx	554	24	bind	bind	VBP
cord-280549-bsnz24jx	554	25	almost	almost	RB
cord-280549-bsnz24jx	554	26	exclusively	exclusively	RB
cord-280549-bsnz24jx	554	27	to	to	IN
cord-280549-bsnz24jx	554	28	CDK6	CDK6	NNP
cord-280549-bsnz24jx	555	1	(	(	-LRB-
cord-280549-bsnz24jx	555	2	Godden	Godden	NNP
cord-280549-bsnz24jx	555	3	-	-	HYPH
cord-280549-bsnz24jx	555	4	Kent	Kent	NNP
cord-280549-bsnz24jx	555	5	et	et	NNP
cord-280549-bsnz24jx	555	6	al	al	NNP
cord-280549-bsnz24jx	555	7	.	.	NNP
cord-280549-bsnz24jx	555	8	,	,	,
cord-280549-bsnz24jx	555	9	1997	1997	CD
cord-280549-bsnz24jx	555	10	)	)	-RRB-
cord-280549-bsnz24jx	555	11	.	.	.
cord-280549-bsnz24jx	556	1	Of	of	IN
cord-280549-bsnz24jx	556	2	note	note	NN
cord-280549-bsnz24jx	556	3	,	,	,
cord-280549-bsnz24jx	556	4	KSHV	KSHV	NNP
cord-280549-bsnz24jx	556	5	-	-	HYPH
cord-280549-bsnz24jx	556	6	cyclin	cyclin	NN
cord-280549-bsnz24jx	556	7	can	can	MD
cord-280549-bsnz24jx	556	8	activate	activate	VB
cord-280549-bsnz24jx	556	9	CDK6	CDK6	NNP
cord-280549-bsnz24jx	556	10	independent	independent	NN
cord-280549-bsnz24jx	556	11	of	of	IN
cord-280549-bsnz24jx	556	12	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	556	13	by	by	IN
cord-280549-bsnz24jx	556	14	CAK	CAK	NNP
cord-280549-bsnz24jx	556	15	in	in	IN
cord-280549-bsnz24jx	556	16	vitro	vitro	FW
cord-280549-bsnz24jx	556	17	and	and	CC
cord-280549-bsnz24jx	556	18	in	in	IN
cord-280549-bsnz24jx	556	19	vivo	vivo	FW
cord-280549-bsnz24jx	556	20	(	(	-LRB-
cord-280549-bsnz24jx	556	21	Kaldis	Kaldis	NNP
cord-280549-bsnz24jx	556	22	,	,	,
cord-280549-bsnz24jx	556	23	1999	1999	CD
cord-280549-bsnz24jx	556	24	)	)	-RRB-
cord-280549-bsnz24jx	556	25	.	.	.
cord-280549-bsnz24jx	557	1	Moreover	moreover	RB
cord-280549-bsnz24jx	557	2	,	,	,
cord-280549-bsnz24jx	557	3	the	the	DT
cord-280549-bsnz24jx	557	4	kinase	kinase	NN
cord-280549-bsnz24jx	557	5	activity	activity	NN
cord-280549-bsnz24jx	557	6	of	of	IN
cord-280549-bsnz24jx	557	7	v	v	NN
cord-280549-bsnz24jx	557	8	-	-	HYPH
cord-280549-bsnz24jx	557	9	cyclin	cyclin	NN
cord-280549-bsnz24jx	557	10	-	-	:
cord-280549-bsnz24jx	557	11	CDK6	CDK6	NNP
cord-280549-bsnz24jx	557	12	appears	appear	VBZ
cord-280549-bsnz24jx	557	13	to	to	TO
cord-280549-bsnz24jx	557	14	be	be	VB
cord-280549-bsnz24jx	557	15	much	much	RB
cord-280549-bsnz24jx	557	16	stronger	strong	JJR
cord-280549-bsnz24jx	557	17	than	than	IN
cord-280549-bsnz24jx	557	18	cyclin	cyclin	NNP
cord-280549-bsnz24jx	557	19	D1-CDK6	D1-CDK6	NNP
cord-280549-bsnz24jx	557	20	,	,	,
cord-280549-bsnz24jx	557	21	targeting	target	VBG
cord-280549-bsnz24jx	557	22	also	also	RB
cord-280549-bsnz24jx	557	23	histone	histone	NNP
cord-280549-bsnz24jx	557	24	H1	H1	NNP
cord-280549-bsnz24jx	557	25	,	,	,
cord-280549-bsnz24jx	557	26	which	which	WDT
cord-280549-bsnz24jx	557	27	is	be	VBZ
cord-280549-bsnz24jx	557	28	a	a	DT
cord-280549-bsnz24jx	557	29	preferred	preferred	JJ
cord-280549-bsnz24jx	557	30	substrate	substrate	NN
cord-280549-bsnz24jx	557	31	of	of	IN
cord-280549-bsnz24jx	557	32	CDK2	CDK2	NNP
cord-280549-bsnz24jx	557	33	rather	rather	RB
cord-280549-bsnz24jx	557	34	than	than	IN
cord-280549-bsnz24jx	557	35	CDK6	CDK6	NNP
cord-280549-bsnz24jx	558	1	(	(	-LRB-
cord-280549-bsnz24jx	558	2	Alexandrow	Alexandrow	NNP
cord-280549-bsnz24jx	558	3	and	and	CC
cord-280549-bsnz24jx	558	4	Hamlin	Hamlin	NNP
cord-280549-bsnz24jx	558	5	,	,	,
cord-280549-bsnz24jx	558	6	2005	2005	CD
cord-280549-bsnz24jx	558	7	)	)	-RRB-
cord-280549-bsnz24jx	558	8	.	.	.
cord-280549-bsnz24jx	559	1	This	this	DT
cord-280549-bsnz24jx	559	2	finding	finding	NN
cord-280549-bsnz24jx	559	3	suggests	suggest	VBZ
cord-280549-bsnz24jx	559	4	a	a	DT
cord-280549-bsnz24jx	559	5	transformation	transformation	NN
cord-280549-bsnz24jx	559	6	potential	potential	NN
cord-280549-bsnz24jx	559	7	of	of	IN
cord-280549-bsnz24jx	559	8	v	v	NN
cord-280549-bsnz24jx	559	9	-	-	NN
cord-280549-bsnz24jx	559	10	cyclin	cyclin	VB
cord-280549-bsnz24jx	559	11	through	through	IN
cord-280549-bsnz24jx	559	12	"	"	``
cord-280549-bsnz24jx	559	13	hyperactivation	hyperactivation	NN
cord-280549-bsnz24jx	559	14	"	"	''
cord-280549-bsnz24jx	559	15	of	of	IN
cord-280549-bsnz24jx	559	16	CDK6	CDK6	NNP
cord-280549-bsnz24jx	560	1	(	(	-LRB-
cord-280549-bsnz24jx	560	2	Jung	Jung	NNP
cord-280549-bsnz24jx	560	3	et	et	NNP
cord-280549-bsnz24jx	560	4	al	al	NNP
cord-280549-bsnz24jx	560	5	.	.	.
cord-280549-bsnz24jx	561	1	,	,	,
cord-280549-bsnz24jx	561	2	1994	1994	CD
cord-280549-bsnz24jx	561	3	;	;	:
cord-280549-bsnz24jx	561	4	Swanton	Swanton	NNP
cord-280549-bsnz24jx	561	5	et	et	NNP
cord-280549-bsnz24jx	561	6	al	al	NNP
cord-280549-bsnz24jx	561	7	.	.	NNP
cord-280549-bsnz24jx	561	8	,	,	,
cord-280549-bsnz24jx	561	9	1997	1997	CD
cord-280549-bsnz24jx	561	10	)	)	-RRB-
cord-280549-bsnz24jx	561	11	.	.	.
cord-280549-bsnz24jx	562	1	In	in	IN
cord-280549-bsnz24jx	562	2	fact	fact	NN
cord-280549-bsnz24jx	562	3	,	,	,
cord-280549-bsnz24jx	562	4	ectopic	ectopic	JJ
cord-280549-bsnz24jx	562	5	expression	expression	NN
cord-280549-bsnz24jx	562	6	of	of	IN
cord-280549-bsnz24jx	562	7	KSHV	KSHV	NNP
cord-280549-bsnz24jx	562	8	v	v	NNP
cord-280549-bsnz24jx	562	9	-	-	HYPH
cord-280549-bsnz24jx	562	10	cyclin	cyclin	NN
cord-280549-bsnz24jx	562	11	abolishes	abolish	VBZ
cord-280549-bsnz24jx	562	12	the	the	DT
cord-280549-bsnz24jx	562	13	cell	cell	NN
cord-280549-bsnz24jx	562	14	cycle	cycle	NN
cord-280549-bsnz24jx	562	15	arrest	arrest	NN
cord-280549-bsnz24jx	562	16	effect	effect	NN
cord-280549-bsnz24jx	562	17	imposed	impose	VBN
cord-280549-bsnz24jx	562	18	by	by	IN
cord-280549-bsnz24jx	562	19	Rb	Rb	NNP
cord-280549-bsnz24jx	562	20	,	,	,
cord-280549-bsnz24jx	562	21	which	which	WDT
cord-280549-bsnz24jx	562	22	is	be	VBZ
cord-280549-bsnz24jx	562	23	related	relate	VBN
cord-280549-bsnz24jx	562	24	to	to	IN
cord-280549-bsnz24jx	562	25	Rb	Rb	NNP
cord-280549-bsnz24jx	562	26	hyperphosphorylation	hyperphosphorylation	NN
cord-280549-bsnz24jx	562	27	and	and	CC
cord-280549-bsnz24jx	562	28	functional	functional	JJ
cord-280549-bsnz24jx	562	29	inactivation	inactivation	NN
cord-280549-bsnz24jx	563	1	(	(	-LRB-
cord-280549-bsnz24jx	563	2	Chang	Chang	NNP
cord-280549-bsnz24jx	563	3	et	et	NNP
cord-280549-bsnz24jx	563	4	al	al	NNP
cord-280549-bsnz24jx	563	5	.	.	NNP
cord-280549-bsnz24jx	563	6	,	,	,
cord-280549-bsnz24jx	563	7	1996	1996	CD
cord-280549-bsnz24jx	563	8	)	)	-RRB-
cord-280549-bsnz24jx	563	9	.	.	.
cord-280549-bsnz24jx	564	1	In	in	IN
cord-280549-bsnz24jx	564	2	support	support	NN
cord-280549-bsnz24jx	564	3	of	of	IN
cord-280549-bsnz24jx	564	4	these	these	DT
cord-280549-bsnz24jx	564	5	finding	finding	NN
cord-280549-bsnz24jx	564	6	,	,	,
cord-280549-bsnz24jx	564	7	MHV	MHV	NNP
cord-280549-bsnz24jx	564	8	v	v	NN
cord-280549-bsnz24jx	564	9	-	-	HYPH
cord-280549-bsnz24jx	564	10	cyclin	cyclin	NN
cord-280549-bsnz24jx	564	11	-	-	HYPH
cord-280549-bsnz24jx	564	12	transgenic	transgenic	JJ
cord-280549-bsnz24jx	564	13	mice	mouse	NNS
cord-280549-bsnz24jx	564	14	display	display	VBP
cord-280549-bsnz24jx	564	15	a	a	DT
cord-280549-bsnz24jx	564	16	significant	significant	JJ
cord-280549-bsnz24jx	564	17	increase	increase	NN
cord-280549-bsnz24jx	564	18	in	in	IN
cord-280549-bsnz24jx	564	19	thymocyte	thymocyte	NN
cord-280549-bsnz24jx	564	20	number	number	NN
cord-280549-bsnz24jx	564	21	with	with	IN
cord-280549-bsnz24jx	564	22	promoted	promote	VBN
cord-280549-bsnz24jx	564	23	cell	cell	NN
cord-280549-bsnz24jx	564	24	cycle	cycle	NN
cord-280549-bsnz24jx	564	25	progression	progression	NN
cord-280549-bsnz24jx	564	26	and	and	CC
cord-280549-bsnz24jx	564	27	also	also	RB
cord-280549-bsnz24jx	564	28	develop	develop	VB
cord-280549-bsnz24jx	564	29	high	high	JJ
cord-280549-bsnz24jx	564	30	-	-	HYPH
cord-280549-bsnz24jx	564	31	grade	grade	NN
cord-280549-bsnz24jx	564	32	lymphoblastic	lymphoblastic	JJ
cord-280549-bsnz24jx	564	33	lymphoma	lymphoma	NN
cord-280549-bsnz24jx	564	34	(	(	-LRB-
cord-280549-bsnz24jx	564	35	van	van	NNP
cord-280549-bsnz24jx	564	36	Dyk	Dyk	NNP
cord-280549-bsnz24jx	564	37	et	et	FW
cord-280549-bsnz24jx	564	38	al	al	NNP
cord-280549-bsnz24jx	564	39	.	.	NNP
cord-280549-bsnz24jx	564	40	,	,	,
cord-280549-bsnz24jx	564	41	1999	1999	CD
cord-280549-bsnz24jx	564	42	)	)	-RRB-
cord-280549-bsnz24jx	564	43	.	.	.
cord-280549-bsnz24jx	565	1	Furthermore	furthermore	RB
cord-280549-bsnz24jx	565	2	,	,	,
cord-280549-bsnz24jx	565	3	the	the	DT
cord-280549-bsnz24jx	565	4	v	v	NN
cord-280549-bsnz24jx	565	5	-	-	HYPH
cord-280549-bsnz24jx	565	6	cyclin	cyclin	NN
cord-280549-bsnz24jx	565	7	-	-	HYPH
cord-280549-bsnz24jx	565	8	CDK	CDK	NNP
cord-280549-bsnz24jx	565	9	complexes	complex	NNS
cord-280549-bsnz24jx	565	10	are	be	VBP
cord-280549-bsnz24jx	565	11	significantly	significantly	RB
cord-280549-bsnz24jx	565	12	more	more	RBR
cord-280549-bsnz24jx	565	13	resistant	resistant	JJ
cord-280549-bsnz24jx	565	14	to	to	IN
cord-280549-bsnz24jx	565	15	the	the	DT
cord-280549-bsnz24jx	565	16	inhibition	inhibition	NN
cord-280549-bsnz24jx	565	17	imposed	impose	VBN
cord-280549-bsnz24jx	565	18	by	by	IN
cord-280549-bsnz24jx	565	19	p21	p21	NN
cord-280549-bsnz24jx	565	20	WAF1	WAF1	NNP
cord-280549-bsnz24jx	565	21	/	/	SYM
cord-280549-bsnz24jx	565	22	CIP1	CIP1	NNP
cord-280549-bsnz24jx	565	23	,	,	,
cord-280549-bsnz24jx	565	24	p27	p27	NNP
cord-280549-bsnz24jx	565	25	KIP1	KIP1	NNP
cord-280549-bsnz24jx	565	26	,	,	,
cord-280549-bsnz24jx	565	27	and	and	CC
cord-280549-bsnz24jx	565	28	p16	p16	NN
cord-280549-bsnz24jx	565	29	INK4A	INK4A	NNS
cord-280549-bsnz24jx	565	30	than	than	IN
cord-280549-bsnz24jx	565	31	cyclin	cyclin	NN
cord-280549-bsnz24jx	565	32	D1-CDK	D1-CDK	NNP
cord-280549-bsnz24jx	565	33	complexes	complex	NNS
cord-280549-bsnz24jx	565	34	in	in	IN
cord-280549-bsnz24jx	565	35	vitro	vitro	FW
cord-280549-bsnz24jx	565	36	(	(	-LRB-
cord-280549-bsnz24jx	565	37	Swanton	Swanton	NNP
cord-280549-bsnz24jx	565	38	et	et	NNP
cord-280549-bsnz24jx	565	39	al	al	NNP
cord-280549-bsnz24jx	565	40	.	.	NNP
cord-280549-bsnz24jx	565	41	,	,	,
cord-280549-bsnz24jx	565	42	1997	1997	CD
cord-280549-bsnz24jx	565	43	)	)	-RRB-
cord-280549-bsnz24jx	565	44	.	.	.
cord-280549-bsnz24jx	566	1	Lack	lack	JJ
cord-280549-bsnz24jx	566	2	or	or	CC
cord-280549-bsnz24jx	566	3	weak	weak	JJ
cord-280549-bsnz24jx	566	4	association	association	NN
cord-280549-bsnz24jx	566	5	of	of	IN
cord-280549-bsnz24jx	566	6	p21	p21	NNP
cord-280549-bsnz24jx	566	7	WAF1	WAF1	NNP
cord-280549-bsnz24jx	566	8	/	/	SYM
cord-280549-bsnz24jx	566	9	CIP1	CIP1	NNP
cord-280549-bsnz24jx	566	10	and	and	CC
cord-280549-bsnz24jx	566	11	p27	p27	NN
cord-280549-bsnz24jx	566	12	KIP1	KIP1	NNP
cord-280549-bsnz24jx	566	13	with	with	IN
cord-280549-bsnz24jx	566	14	v	v	NN
cord-280549-bsnz24jx	566	15	-	-	HYPH
cord-280549-bsnz24jx	566	16	cyclin	cyclin	NN
cord-280549-bsnz24jx	566	17	likely	likely	RB
cord-280549-bsnz24jx	566	18	defines	define	VBZ
cord-280549-bsnz24jx	566	19	the	the	DT
cord-280549-bsnz24jx	566	20	inefficiency	inefficiency	NN
cord-280549-bsnz24jx	566	21	of	of	IN
cord-280549-bsnz24jx	566	22	these	these	DT
cord-280549-bsnz24jx	566	23	CKI	CKI	NNP
cord-280549-bsnz24jx	566	24	to	to	TO
cord-280549-bsnz24jx	566	25	inhibit	inhibit	VB
cord-280549-bsnz24jx	566	26	them	-PRON-	PRP
cord-280549-bsnz24jx	567	1	(	(	-LRB-
cord-280549-bsnz24jx	567	2	Swanton	Swanton	NNP
cord-280549-bsnz24jx	567	3	et	et	NNP
cord-280549-bsnz24jx	567	4	al	al	NNP
cord-280549-bsnz24jx	567	5	.	.	.
cord-280549-bsnz24jx	568	1	,	,	,
cord-280549-bsnz24jx	568	2	1997	1997	CD
cord-280549-bsnz24jx	568	3	;	;	:
cord-280549-bsnz24jx	568	4	Schulze	Schulze	NNP
cord-280549-bsnz24jx	568	5	-	-	HYPH
cord-280549-bsnz24jx	568	6	Gahmen	Gahmen	NNP
cord-280549-bsnz24jx	568	7	et	et	FW
cord-280549-bsnz24jx	568	8	al	al	NNP
cord-280549-bsnz24jx	568	9	.	.	.
cord-280549-bsnz24jx	569	1	,	,	,
cord-280549-bsnz24jx	569	2	1999	1999	CD
cord-280549-bsnz24jx	569	3	;	;	:
cord-280549-bsnz24jx	569	4	Card	card	NN
cord-280549-bsnz24jx	569	5	et	et	FW
cord-280549-bsnz24jx	569	6	al	al	NNP
cord-280549-bsnz24jx	569	7	.	.	.
cord-280549-bsnz24jx	570	1	,	,	,
cord-280549-bsnz24jx	570	2	2000	2000	CD
cord-280549-bsnz24jx	570	3	)	)	-RRB-
cord-280549-bsnz24jx	570	4	.	.	.
cord-280549-bsnz24jx	571	1	It	-PRON-	PRP
cord-280549-bsnz24jx	571	2	is	be	VBZ
cord-280549-bsnz24jx	571	3	currently	currently	RB
cord-280549-bsnz24jx	571	4	unclear	unclear	JJ
cord-280549-bsnz24jx	571	5	how	how	WRB
cord-280549-bsnz24jx	571	6	v	v	NN
cord-280549-bsnz24jx	571	7	-	-	:
cord-280549-bsnz24jx	571	8	cyclins	cyclin	NNS
cord-280549-bsnz24jx	571	9	antagonize	antagonize	VBP
cord-280549-bsnz24jx	571	10	the	the	DT
cord-280549-bsnz24jx	571	11	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	571	12	effect	effect	NN
cord-280549-bsnz24jx	571	13	of	of	IN
cord-280549-bsnz24jx	571	14	p16	p16	NN
cord-280549-bsnz24jx	571	15	INK4A	INK4A	NNS
cord-280549-bsnz24jx	571	16	since	since	IN
cord-280549-bsnz24jx	571	17	this	this	DT
cord-280549-bsnz24jx	571	18	CKI	CKI	NNP
cord-280549-bsnz24jx	571	19	acts	act	VBZ
cord-280549-bsnz24jx	571	20	by	by	IN
cord-280549-bsnz24jx	571	21	inhibiting	inhibit	VBG
cord-280549-bsnz24jx	571	22	the	the	DT
cord-280549-bsnz24jx	571	23	catalytic	catalytic	JJ
cord-280549-bsnz24jx	571	24	subunit	subunit	NN
cord-280549-bsnz24jx	571	25	of	of	IN
cord-280549-bsnz24jx	571	26	CDK4	CDK4	NNP
cord-280549-bsnz24jx	571	27	and	and	CC
cord-280549-bsnz24jx	571	28	CDK6	CDK6	NNP
cord-280549-bsnz24jx	572	1	(	(	-LRB-
cord-280549-bsnz24jx	572	2	Sherr	Sherr	NNP
cord-280549-bsnz24jx	572	3	and	and	CC
cord-280549-bsnz24jx	572	4	Roberts	Roberts	NNP
cord-280549-bsnz24jx	572	5	,	,	,
cord-280549-bsnz24jx	572	6	1999	1999	CD
cord-280549-bsnz24jx	572	7	)	)	-RRB-
cord-280549-bsnz24jx	572	8	.	.	.
cord-280549-bsnz24jx	573	1	One	one	CD
cord-280549-bsnz24jx	573	2	hypothesis	hypothesis	NN
cord-280549-bsnz24jx	573	3	is	be	VBZ
cord-280549-bsnz24jx	573	4	that	that	IN
cord-280549-bsnz24jx	573	5	higher	high	JJR
cord-280549-bsnz24jx	573	6	affinity	affinity	NN
cord-280549-bsnz24jx	573	7	of	of	IN
cord-280549-bsnz24jx	573	8	vcyclin	vcyclin	NN
cord-280549-bsnz24jx	573	9	for	for	IN
cord-280549-bsnz24jx	573	10	CDK6	CDK6	NNP
cord-280549-bsnz24jx	573	11	than	than	IN
cord-280549-bsnz24jx	573	12	p16	p16	NN
cord-280549-bsnz24jx	573	13	INK4A	INK4A	NNS
cord-280549-bsnz24jx	573	14	may	may	MD
cord-280549-bsnz24jx	573	15	prevent	prevent	VB
cord-280549-bsnz24jx	573	16	its	-PRON-	PRP$
cord-280549-bsnz24jx	573	17	displacement	displacement	NN
cord-280549-bsnz24jx	573	18	by	by	IN
cord-280549-bsnz24jx	573	19	p16	p16	NN
cord-280549-bsnz24jx	573	20	INK4A	INK4A	NNS
cord-280549-bsnz24jx	573	21	.	.	.
cord-280549-bsnz24jx	574	1	Deletion	deletion	NN
cord-280549-bsnz24jx	574	2	of	of	IN
cord-280549-bsnz24jx	574	3	the	the	DT
cord-280549-bsnz24jx	574	4	p16	p16	NN
cord-280549-bsnz24jx	574	5	INK4A	ink4a	NN
cord-280549-bsnz24jx	574	6	locus	locus	NN
cord-280549-bsnz24jx	574	7	was	be	VBD
cord-280549-bsnz24jx	574	8	identified	identify	VBN
cord-280549-bsnz24jx	574	9	in	in	IN
cord-280549-bsnz24jx	574	10	KSHV	KSHV	NNP
cord-280549-bsnz24jx	574	11	associated	associate	VBD
cord-280549-bsnz24jx	574	12	PEL	PEL	NNP
cord-280549-bsnz24jx	574	13	primary	primary	JJ
cord-280549-bsnz24jx	574	14	samples	sample	NNS
cord-280549-bsnz24jx	574	15	,	,	,
cord-280549-bsnz24jx	574	16	suggesting	suggest	VBG
cord-280549-bsnz24jx	574	17	that	that	IN
cord-280549-bsnz24jx	574	18	loss	loss	NN
cord-280549-bsnz24jx	574	19	of	of	IN
cord-280549-bsnz24jx	574	20	p16	p16	NN
cord-280549-bsnz24jx	574	21	INK4A	INK4A	NNS
cord-280549-bsnz24jx	574	22	may	may	MD
cord-280549-bsnz24jx	574	23	be	be	VB
cord-280549-bsnz24jx	574	24	another	another	DT
cord-280549-bsnz24jx	574	25	mechanism	mechanism	NN
cord-280549-bsnz24jx	574	26	of	of	IN
cord-280549-bsnz24jx	574	27	KSHV	KSHV	NNP
cord-280549-bsnz24jx	574	28	-	-	HYPH
cord-280549-bsnz24jx	574	29	induced	induce	VBN
cord-280549-bsnz24jx	574	30	transformation	transformation	NN
cord-280549-bsnz24jx	574	31	(	(	-LRB-
cord-280549-bsnz24jx	574	32	Platt	Platt	NNP
cord-280549-bsnz24jx	574	33	et	et	NNP
cord-280549-bsnz24jx	574	34	al	al	NNP
cord-280549-bsnz24jx	574	35	.	.	NNP
cord-280549-bsnz24jx	574	36	,	,	,
cord-280549-bsnz24jx	574	37	2002	2002	CD
cord-280549-bsnz24jx	574	38	)	)	-RRB-
cord-280549-bsnz24jx	574	39	.	.	.
cord-280549-bsnz24jx	575	1	In	in	IN
cord-280549-bsnz24jx	575	2	addition	addition	NN
cord-280549-bsnz24jx	575	3	,	,	,
cord-280549-bsnz24jx	575	4	by	by	IN
cord-280549-bsnz24jx	575	5	targeting	target	VBG
cord-280549-bsnz24jx	575	6	p27	p27	NN
cord-280549-bsnz24jx	575	7	KIP1	KIP1	NNP
cord-280549-bsnz24jx	575	8	to	to	IN
cord-280549-bsnz24jx	575	9	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	575	10	-	-	HYPH
cord-280549-bsnz24jx	575	11	dependent	dependent	JJ
cord-280549-bsnz24jx	575	12	degradation	degradation	NN
cord-280549-bsnz24jx	575	13	,	,	,
cord-280549-bsnz24jx	575	14	the	the	DT
cord-280549-bsnz24jx	575	15	v	v	NN
cord-280549-bsnz24jx	575	16	-	-	HYPH
cord-280549-bsnz24jx	575	17	cyclin	cyclin	NN
cord-280549-bsnz24jx	575	18	of	of	IN
cord-280549-bsnz24jx	575	19	KSHV	KSHV	NNP
cord-280549-bsnz24jx	575	20	could	could	MD
cord-280549-bsnz24jx	575	21	prevent	prevent	VB
cord-280549-bsnz24jx	575	22	the	the	DT
cord-280549-bsnz24jx	575	23	G1	G1	NNP
cord-280549-bsnz24jx	575	24	arrest	arrest	NN
cord-280549-bsnz24jx	575	25	induced	induce	VBN
cord-280549-bsnz24jx	575	26	by	by	IN
cord-280549-bsnz24jx	575	27	the	the	DT
cord-280549-bsnz24jx	575	28	viral	viral	JJ
cord-280549-bsnz24jx	575	29	latency	latency	NN
cord-280549-bsnz24jx	575	30	protein	protein	NN
cord-280549-bsnz24jx	575	31	vFLIP	vFLIP	NNP
cord-280549-bsnz24jx	575	32	,	,	,
cord-280549-bsnz24jx	575	33	which	which	WDT
cord-280549-bsnz24jx	575	34	is	be	VBZ
cord-280549-bsnz24jx	575	35	co	co	JJ
cord-280549-bsnz24jx	575	36	-	-	VBN
cord-280549-bsnz24jx	575	37	translated	translate	VBN
cord-280549-bsnz24jx	575	38	from	from	IN
cord-280549-bsnz24jx	575	39	the	the	DT
cord-280549-bsnz24jx	575	40	same	same	JJ
cord-280549-bsnz24jx	575	41	viral	viral	JJ
cord-280549-bsnz24jx	575	42	mRNA	mrna	NN
cord-280549-bsnz24jx	575	43	as	as	IN
cord-280549-bsnz24jx	575	44	v	v	NN
cord-280549-bsnz24jx	575	45	-	-	NN
cord-280549-bsnz24jx	575	46	cyclin	cyclin	NN
cord-280549-bsnz24jx	576	1	(	(	-LRB-
cord-280549-bsnz24jx	576	2	Vlach	Vlach	NNP
cord-280549-bsnz24jx	576	3	et	et	FW
cord-280549-bsnz24jx	576	4	al	al	NNP
cord-280549-bsnz24jx	576	5	.	.	NNP
cord-280549-bsnz24jx	576	6	,	,	,
cord-280549-bsnz24jx	576	7	1997	1997	CD
cord-280549-bsnz24jx	576	8	;	;	.
cord-280549-bsnz24jx	577	1	Mann	Mann	NNP
cord-280549-bsnz24jx	577	2	et	et	NNP
cord-280549-bsnz24jx	577	3	al	al	NNP
cord-280549-bsnz24jx	577	4	.	.	NNP
cord-280549-bsnz24jx	577	5	,	,	,
cord-280549-bsnz24jx	577	6	1999	1999	CD
cord-280549-bsnz24jx	578	1	;	;	:
cord-280549-bsnz24jx	578	2	Zhi	Zhi	NNP
cord-280549-bsnz24jx	578	3	et	et	FW
cord-280549-bsnz24jx	578	4	al	al	NNP
cord-280549-bsnz24jx	578	5	.	.	NNP
cord-280549-bsnz24jx	578	6	,	,	,
cord-280549-bsnz24jx	578	7	2015	2015	CD
cord-280549-bsnz24jx	578	8	)	)	-RRB-
cord-280549-bsnz24jx	578	9	.	.	.
cord-280549-bsnz24jx	579	1	This	this	DT
cord-280549-bsnz24jx	579	2	was	be	VBD
cord-280549-bsnz24jx	579	3	also	also	RB
cord-280549-bsnz24jx	579	4	demonstrated	demonstrate	VBN
cord-280549-bsnz24jx	579	5	by	by	IN
cord-280549-bsnz24jx	579	6	the	the	DT
cord-280549-bsnz24jx	579	7	inability	inability	NN
cord-280549-bsnz24jx	579	8	of	of	IN
cord-280549-bsnz24jx	579	9	KSHV	KSHV	NNP
cord-280549-bsnz24jx	579	10	v	v	NNP
cord-280549-bsnz24jx	579	11	-	-	:
cord-280549-bsnz24jx	579	12	cyclin	cyclin	NN
cord-280549-bsnz24jx	579	13	to	to	TO
cord-280549-bsnz24jx	579	14	escape	escape	VB
cord-280549-bsnz24jx	579	15	p27	p27	NNP
cord-280549-bsnz24jx	579	16	KIP1	KIP1	NNP
cord-280549-bsnz24jx	579	17	mediated	mediate	VBD
cord-280549-bsnz24jx	579	18	cell	cell	NN
cord-280549-bsnz24jx	579	19	cycle	cycle	NN
cord-280549-bsnz24jx	579	20	arrest	arrest	NN
cord-280549-bsnz24jx	579	21	when	when	WRB
cord-280549-bsnz24jx	579	22	p27	p27	NN
cord-280549-bsnz24jx	579	23	KIP1	KIP1	NNP
cord-280549-bsnz24jx	579	24	is	be	VBZ
cord-280549-bsnz24jx	579	25	mutated	mutate	VBN
cord-280549-bsnz24jx	579	26	to	to	IN
cord-280549-bsnz24jx	579	27	a	a	DT
cord-280549-bsnz24jx	579	28	form	form	NN
cord-280549-bsnz24jx	579	29	that	that	WDT
cord-280549-bsnz24jx	579	30	can	can	MD
cord-280549-bsnz24jx	579	31	not	not	RB
cord-280549-bsnz24jx	579	32	be	be	VB
cord-280549-bsnz24jx	579	33	phosphorylated	phosphorylate	VBN
cord-280549-bsnz24jx	579	34	.	.	.
cord-280549-bsnz24jx	580	1	Moreover	moreover	RB
cord-280549-bsnz24jx	580	2	,	,	,
cord-280549-bsnz24jx	580	3	p27	p27	NN
cord-280549-bsnz24jx	580	4	KIP1	KIP1	NNP
cord-280549-bsnz24jx	580	5	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	580	6	on	on	IN
cord-280549-bsnz24jx	580	7	Ser10	Ser10	NNP
cord-280549-bsnz24jx	580	8	by	by	IN
cord-280549-bsnz24jx	580	9	KSHV	KSHV	NNP
cord-280549-bsnz24jx	581	1	v	v	LS
cord-280549-bsnz24jx	581	2	-	-	:
cord-280549-bsnz24jx	581	3	cyclin	cyclin	NN
cord-280549-bsnz24jx	581	4	-	-	HYPH
cord-280549-bsnz24jx	581	5	CDK6	CDK6	NNP
cord-280549-bsnz24jx	581	6	complex	complex	NN
cord-280549-bsnz24jx	581	7	enhances	enhance	VBZ
cord-280549-bsnz24jx	581	8	its	-PRON-	PRP$
cord-280549-bsnz24jx	581	9	cytoplasmic	cytoplasmic	JJ
cord-280549-bsnz24jx	581	10	dislocation	dislocation	NN
cord-280549-bsnz24jx	581	11	,	,	,
cord-280549-bsnz24jx	581	12	which	which	WDT
cord-280549-bsnz24jx	581	13	serves	serve	VBZ
cord-280549-bsnz24jx	581	14	as	as	IN
cord-280549-bsnz24jx	581	15	another	another	DT
cord-280549-bsnz24jx	581	16	means	mean	VBZ
cord-280549-bsnz24jx	581	17	to	to	TO
cord-280549-bsnz24jx	581	18	facilitate	facilitate	VB
cord-280549-bsnz24jx	581	19	cell	cell	NN
cord-280549-bsnz24jx	581	20	cycle	cycle	NN
cord-280549-bsnz24jx	581	21	progression	progression	NN
cord-280549-bsnz24jx	581	22	(	(	-LRB-
cord-280549-bsnz24jx	581	23	Boehm	Boehm	NNP
cord-280549-bsnz24jx	581	24	et	et	NNP
cord-280549-bsnz24jx	581	25	al	al	NNP
cord-280549-bsnz24jx	581	26	.	.	NNP
cord-280549-bsnz24jx	581	27	,	,	,
cord-280549-bsnz24jx	581	28	2002	2002	CD
cord-280549-bsnz24jx	581	29	;	;	:
cord-280549-bsnz24jx	581	30	Ishida	Ishida	NNP
cord-280549-bsnz24jx	581	31	et	et	NNP
cord-280549-bsnz24jx	581	32	al	al	NNP
cord-280549-bsnz24jx	581	33	.	.	NNP
cord-280549-bsnz24jx	581	34	,	,	,
cord-280549-bsnz24jx	581	35	2002	2002	CD
cord-280549-bsnz24jx	581	36	;	;	:
cord-280549-bsnz24jx	581	37	Sarek	Sarek	NNP
cord-280549-bsnz24jx	581	38	et	et	NNP
cord-280549-bsnz24jx	581	39	al	al	NNP
cord-280549-bsnz24jx	581	40	.	.	NNP
cord-280549-bsnz24jx	581	41	,	,	,
cord-280549-bsnz24jx	581	42	2006	2006	CD
cord-280549-bsnz24jx	581	43	)	)	-RRB-
cord-280549-bsnz24jx	581	44	.	.	.
cord-280549-bsnz24jx	582	1	Similarly	similarly	RB
cord-280549-bsnz24jx	582	2	,	,	,
cord-280549-bsnz24jx	582	3	CDK2	CDK2	NNP
cord-280549-bsnz24jx	582	4	associated	associate	VBD
cord-280549-bsnz24jx	582	5	with	with	IN
cord-280549-bsnz24jx	582	6	v	v	NN
cord-280549-bsnz24jx	582	7	-	-	NN
cord-280549-bsnz24jx	582	8	cyclin	cyclin	NN
cord-280549-bsnz24jx	582	9	of	of	IN
cord-280549-bsnz24jx	582	10	MHV68	MHV68	NNP
cord-280549-bsnz24jx	582	11	exhibits	exhibit	VBZ
cord-280549-bsnz24jx	582	12	substantial	substantial	JJ
cord-280549-bsnz24jx	582	13	resistance	resistance	NN
cord-280549-bsnz24jx	582	14	to	to	IN
cord-280549-bsnz24jx	582	15	both	both	DT
cord-280549-bsnz24jx	582	16	p21	p21	NN
cord-280549-bsnz24jx	582	17	WAF1	WAF1	NNP
cord-280549-bsnz24jx	582	18	/	/	SYM
cord-280549-bsnz24jx	582	19	CIP1	CIP1	NNP
cord-280549-bsnz24jx	582	20	and	and	CC
cord-280549-bsnz24jx	582	21	p27	p27	NN
cord-280549-bsnz24jx	582	22	KIP1	KIP1	NNP
cord-280549-bsnz24jx	582	23	,	,	,
cord-280549-bsnz24jx	582	24	while	while	IN
cord-280549-bsnz24jx	582	25	inducing	induce	VBG
cord-280549-bsnz24jx	582	26	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	582	27	of	of	IN
cord-280549-bsnz24jx	582	28	p27	p27	NN
cord-280549-bsnz24jx	582	29	KIP1	KIP1	NNP
cord-280549-bsnz24jx	582	30	to	to	TO
cord-280549-bsnz24jx	582	31	overcome	overcome	VB
cord-280549-bsnz24jx	582	32	p27	p27	NN
cord-280549-bsnz24jx	582	33	KIP1	KIP1	NNP
cord-280549-bsnz24jx	582	34	-mediated	-mediate	VBD
cord-280549-bsnz24jx	582	35	G1	G1	NNP
cord-280549-bsnz24jx	582	36	arrest	arrest	NN
cord-280549-bsnz24jx	582	37	(	(	-LRB-
cord-280549-bsnz24jx	582	38	Yarmishyn	Yarmishyn	NNP
cord-280549-bsnz24jx	582	39	et	et	FW
cord-280549-bsnz24jx	582	40	al	al	NNP
cord-280549-bsnz24jx	582	41	.	.	NNP
cord-280549-bsnz24jx	582	42	,	,	,
cord-280549-bsnz24jx	582	43	2008	2008	CD
cord-280549-bsnz24jx	582	44	)	)	-RRB-
cord-280549-bsnz24jx	582	45	.	.	.
cord-280549-bsnz24jx	583	1	However	however	RB
cord-280549-bsnz24jx	583	2	,	,	,
cord-280549-bsnz24jx	583	3	v	v	LS
cord-280549-bsnz24jx	583	4	-	-	NN
cord-280549-bsnz24jx	583	5	cyclin	cyclin	NN
cord-280549-bsnz24jx	583	6	of	of	IN
cord-280549-bsnz24jx	583	7	MHV68	MHV68	NNP
cord-280549-bsnz24jx	583	8	is	be	VBZ
cord-280549-bsnz24jx	583	9	only	only	RB
cord-280549-bsnz24jx	583	10	able	able	JJ
cord-280549-bsnz24jx	583	11	to	to	TO
cord-280549-bsnz24jx	583	12	subvert	subvert	VB
cord-280549-bsnz24jx	583	13	p27	p27	NN
cord-280549-bsnz24jx	583	14	KIP1	KIP1	NNP
cord-280549-bsnz24jx	583	15	-imposed	-impose	VBD
cord-280549-bsnz24jx	583	16	G1	G1	NNP
cord-280549-bsnz24jx	583	17	arrest	arrest	NN
cord-280549-bsnz24jx	583	18	,	,	,
cord-280549-bsnz24jx	583	19	but	but	CC
cord-280549-bsnz24jx	583	20	not	not	RB
cord-280549-bsnz24jx	583	21	that	that	IN
cord-280549-bsnz24jx	583	22	imposed	impose	VBN
cord-280549-bsnz24jx	583	23	by	by	IN
cord-280549-bsnz24jx	583	24	p21	p21	NN
cord-280549-bsnz24jx	583	25	WAF1	WAF1	NNP
cord-280549-bsnz24jx	583	26	/	/	SYM
cord-280549-bsnz24jx	583	27	CIP1	CIP1	NNP
cord-280549-bsnz24jx	583	28	(	(	-LRB-
cord-280549-bsnz24jx	583	29	Yarmishyn	Yarmishyn	NNP
cord-280549-bsnz24jx	583	30	et	et	FW
cord-280549-bsnz24jx	583	31	al	al	NNP
cord-280549-bsnz24jx	583	32	.	.	NNP
cord-280549-bsnz24jx	583	33	,	,	,
cord-280549-bsnz24jx	583	34	2008	2008	CD
cord-280549-bsnz24jx	583	35	)	)	-RRB-
cord-280549-bsnz24jx	583	36	.	.	.
cord-280549-bsnz24jx	584	1	Autographa	Autographa	NNP
cord-280549-bsnz24jx	584	2	californica	californica	NNP
cord-280549-bsnz24jx	584	3	nucleopolyhedrovirus	nucleopolyhedrovirus	NNP
cord-280549-bsnz24jx	584	4	(	(	-LRB-
cord-280549-bsnz24jx	584	5	AcMNPV	AcMNPV	NNP
cord-280549-bsnz24jx	584	6	)	)	-RRB-
cord-280549-bsnz24jx	584	7	infects	infect	VBZ
cord-280549-bsnz24jx	584	8	pest	pest	NN
cord-280549-bsnz24jx	584	9	insect	insect	NN
cord-280549-bsnz24jx	584	10	and	and	CC
cord-280549-bsnz24jx	584	11	causes	cause	VBZ
cord-280549-bsnz24jx	584	12	cycle	cycle	NN
cord-280549-bsnz24jx	584	13	arrest	arrest	NN
cord-280549-bsnz24jx	584	14	at	at	IN
cord-280549-bsnz24jx	584	15	G2	G2	NNP
cord-280549-bsnz24jx	584	16	/	/	SYM
cord-280549-bsnz24jx	584	17	M	M	NNP
cord-280549-bsnz24jx	584	18	phase	phase	NN
cord-280549-bsnz24jx	584	19	in	in	IN
cord-280549-bsnz24jx	584	20	host	host	NN
cord-280549-bsnz24jx	584	21	cells	cell	NNS
cord-280549-bsnz24jx	584	22	with	with	IN
cord-280549-bsnz24jx	584	23	continuing	continue	VBG
cord-280549-bsnz24jx	584	24	viral	viral	JJ
cord-280549-bsnz24jx	584	25	DNA	dna	NN
cord-280549-bsnz24jx	584	26	replication	replication	NN
cord-280549-bsnz24jx	584	27	.	.	.
cord-280549-bsnz24jx	585	1	Sole	sole	JJ
cord-280549-bsnz24jx	585	2	expression	expression	NN
cord-280549-bsnz24jx	585	3	of	of	IN
cord-280549-bsnz24jx	585	4	the	the	DT
cord-280549-bsnz24jx	585	5	IE2	ie2	JJ
cord-280549-bsnz24jx	585	6	protein	protein	NN
cord-280549-bsnz24jx	585	7	of	of	IN
cord-280549-bsnz24jx	585	8	AcMNPV	acmnpv	NN
cord-280549-bsnz24jx	585	9	results	result	NNS
cord-280549-bsnz24jx	585	10	in	in	IN
cord-280549-bsnz24jx	585	11	accumulation	accumulation	NN
cord-280549-bsnz24jx	585	12	of	of	IN
cord-280549-bsnz24jx	585	13	enlarged	enlarged	JJ
cord-280549-bsnz24jx	585	14	cells	cell	NNS
cord-280549-bsnz24jx	585	15	with	with	IN
cord-280549-bsnz24jx	585	16	DNA	dna	NN
cord-280549-bsnz24jx	585	17	content	content	NN
cord-280549-bsnz24jx	585	18	greater	great	JJR
cord-280549-bsnz24jx	585	19	than	than	IN
cord-280549-bsnz24jx	585	20	4N	4n	CD
cord-280549-bsnz24jx	585	21	(	(	-LRB-
cord-280549-bsnz24jx	585	22	Prikhod'ko	Prikhod'ko	NNP
cord-280549-bsnz24jx	585	23	and	and	CC
cord-280549-bsnz24jx	585	24	Miller	Miller	NNP
cord-280549-bsnz24jx	585	25	,	,	,
cord-280549-bsnz24jx	585	26	1998	1998	CD
cord-280549-bsnz24jx	585	27	)	)	-RRB-
cord-280549-bsnz24jx	585	28	.	.	.
cord-280549-bsnz24jx	586	1	More	more	RBR
cord-280549-bsnz24jx	586	2	interestingly	interestingly	RB
cord-280549-bsnz24jx	586	3	,	,	,
cord-280549-bsnz24jx	586	4	the	the	DT
cord-280549-bsnz24jx	586	5	structural	structural	JJ
cord-280549-bsnz24jx	586	6	protein	protein	NN
cord-280549-bsnz24jx	586	7	occlusionderived	occlusionderive	VBD
cord-280549-bsnz24jx	586	8	viral	viral	JJ
cord-280549-bsnz24jx	586	9	form	form	NN
cord-280549-bsnz24jx	586	10	(	(	-LRB-
cord-280549-bsnz24jx	586	11	ODV)-EC27	odv)-ec27	NN
cord-280549-bsnz24jx	586	12	is	be	VBZ
cord-280549-bsnz24jx	586	13	endowed	endow	VBN
cord-280549-bsnz24jx	586	14	with	with	IN
cord-280549-bsnz24jx	586	15	cyclin	cyclin	NN
cord-280549-bsnz24jx	586	16	-	-	HYPH
cord-280549-bsnz24jx	586	17	like	like	JJ
cord-280549-bsnz24jx	586	18	activity	activity	NN
cord-280549-bsnz24jx	586	19	,	,	,
cord-280549-bsnz24jx	586	20	making	make	VBG
cord-280549-bsnz24jx	586	21	it	-PRON-	PRP
cord-280549-bsnz24jx	586	22	the	the	DT
cord-280549-bsnz24jx	586	23	second	second	JJ
cord-280549-bsnz24jx	586	24	viral	viral	RB
cord-280549-bsnz24jx	586	25	-	-	HYPH
cord-280549-bsnz24jx	586	26	encoded	encode	VBN
cord-280549-bsnz24jx	586	27	cyclin	cyclin	NN
cord-280549-bsnz24jx	586	28	homolog	homolog	NN
cord-280549-bsnz24jx	586	29	reported	report	VBD
cord-280549-bsnz24jx	586	30	.	.	.
cord-280549-bsnz24jx	587	1	Similar	similar	JJ
cord-280549-bsnz24jx	587	2	to	to	IN
cord-280549-bsnz24jx	587	3	the	the	DT
cord-280549-bsnz24jx	587	4	v	v	NN
cord-280549-bsnz24jx	587	5	-	-	HYPH
cord-280549-bsnz24jx	587	6	cyclins	cyclin	NNS
cord-280549-bsnz24jx	587	7	of	of	IN
cord-280549-bsnz24jx	587	8	herpesviruses	herpesviruses	NNP
cord-280549-bsnz24jx	587	9	,	,	,
cord-280549-bsnz24jx	587	10	association	association	NN
cord-280549-bsnz24jx	587	11	of	of	IN
cord-280549-bsnz24jx	587	12	ODV	ODV	NNP
cord-280549-bsnz24jx	587	13	-	-	HYPH
cord-280549-bsnz24jx	587	14	EC27	EC27	NNP
cord-280549-bsnz24jx	587	15	with	with	IN
cord-280549-bsnz24jx	587	16	CDK6	CDK6	NNP
cord-280549-bsnz24jx	587	17	leads	lead	VBZ
cord-280549-bsnz24jx	587	18	to	to	IN
cord-280549-bsnz24jx	587	19	Rb	Rb	NNP
cord-280549-bsnz24jx	587	20	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	587	21	(	(	-LRB-
cord-280549-bsnz24jx	587	22	Huard	Huard	NNP
cord-280549-bsnz24jx	587	23	et	et	FW
cord-280549-bsnz24jx	587	24	al	al	NNP
cord-280549-bsnz24jx	587	25	.	.	NNP
cord-280549-bsnz24jx	587	26	,	,	,
cord-280549-bsnz24jx	587	27	2008	2008	CD
cord-280549-bsnz24jx	587	28	)	)	-RRB-
cord-280549-bsnz24jx	587	29	.	.	.
cord-280549-bsnz24jx	588	1	Additionally	additionally	RB
cord-280549-bsnz24jx	588	2	,	,	,
cord-280549-bsnz24jx	588	3	ODV	ODV	NNP
cord-280549-bsnz24jx	588	4	-	-	HYPH
cord-280549-bsnz24jx	588	5	EC27	EC27	NNP
cord-280549-bsnz24jx	588	6	was	be	VBD
cord-280549-bsnz24jx	588	7	found	find	VBN
cord-280549-bsnz24jx	588	8	to	to	TO
cord-280549-bsnz24jx	588	9	interact	interact	VB
cord-280549-bsnz24jx	588	10	with	with	IN
cord-280549-bsnz24jx	588	11	CDK1	CDK1	NNP
cord-280549-bsnz24jx	588	12	,	,	,
cord-280549-bsnz24jx	588	13	exerting	exert	VBG
cord-280549-bsnz24jx	588	14	cyclin	cyclin	NN
cord-280549-bsnz24jx	588	15	B	b	NN
cord-280549-bsnz24jx	588	16	-	-	HYPH
cord-280549-bsnz24jx	588	17	like	like	JJ
cord-280549-bsnz24jx	588	18	activity	activity	NN
cord-280549-bsnz24jx	588	19	.	.	.
cord-280549-bsnz24jx	589	1	Walleye	walleye	NN
cord-280549-bsnz24jx	589	2	dermal	dermal	JJ
cord-280549-bsnz24jx	589	3	sarcoma	sarcoma	NN
cord-280549-bsnz24jx	589	4	virus	virus	NN
cord-280549-bsnz24jx	589	5	(	(	-LRB-
cord-280549-bsnz24jx	589	6	WDSV	WDSV	NNP
cord-280549-bsnz24jx	589	7	)	)	-RRB-
cord-280549-bsnz24jx	589	8	and	and	CC
cord-280549-bsnz24jx	589	9	walleye	walleye	NN
cord-280549-bsnz24jx	589	10	epidermal	epidermal	JJ
cord-280549-bsnz24jx	589	11	hyperplasia	hyperplasia	NN
cord-280549-bsnz24jx	589	12	virus	virus	NN
cord-280549-bsnz24jx	589	13	(	(	-LRB-
cord-280549-bsnz24jx	589	14	WEHV	WEHV	NNP
cord-280549-bsnz24jx	589	15	)	)	-RRB-
cord-280549-bsnz24jx	589	16	are	be	VBP
cord-280549-bsnz24jx	589	17	retroviruses	retrovirus	NNS
cord-280549-bsnz24jx	589	18	that	that	WDT
cord-280549-bsnz24jx	589	19	encode	encode	VBP
cord-280549-bsnz24jx	589	20	human	human	JJ
cord-280549-bsnz24jx	589	21	D	d	NN
cord-280549-bsnz24jx	589	22	-	-	HYPH
cord-280549-bsnz24jx	589	23	type	type	NN
cord-280549-bsnz24jx	589	24	cyclin	cyclin	NN
cord-280549-bsnz24jx	589	25	homologs	homolog	NNS
cord-280549-bsnz24jx	589	26	.	.	.
cord-280549-bsnz24jx	590	1	A	a	DT
cord-280549-bsnz24jx	590	2	standard	standard	JJ
cord-280549-bsnz24jx	590	3	yeast	yeast	NN
cord-280549-bsnz24jx	590	4	complementation	complementation	NN
cord-280549-bsnz24jx	590	5	assay	assay	NN
cord-280549-bsnz24jx	590	6	showed	show	VBD
cord-280549-bsnz24jx	590	7	that	that	IN
cord-280549-bsnz24jx	590	8	the	the	DT
cord-280549-bsnz24jx	590	9	retroviral	retroviral	NN
cord-280549-bsnz24jx	590	10	-	-	HYPH
cord-280549-bsnz24jx	590	11	cyclins	cyclin	NNS
cord-280549-bsnz24jx	590	12	(	(	-LRB-
cord-280549-bsnz24jx	590	13	rv	rv	NN
cord-280549-bsnz24jx	590	14	-	-	HYPH
cord-280549-bsnz24jx	590	15	cyclins	cyclin	NNS
cord-280549-bsnz24jx	590	16	)	)	-RRB-
cord-280549-bsnz24jx	590	17	of	of	IN
cord-280549-bsnz24jx	590	18	WDSV	WDSV	NNP
cord-280549-bsnz24jx	590	19	,	,	,
cord-280549-bsnz24jx	590	20	but	but	CC
cord-280549-bsnz24jx	590	21	not	not	RB
cord-280549-bsnz24jx	590	22	that	that	DT
cord-280549-bsnz24jx	590	23	of	of	IN
cord-280549-bsnz24jx	590	24	WEHV	WEHV	NNP
cord-280549-bsnz24jx	590	25	,	,	,
cord-280549-bsnz24jx	590	26	induce	induce	VB
cord-280549-bsnz24jx	590	27	cell	cell	NN
cord-280549-bsnz24jx	590	28	cycle	cycle	NN
cord-280549-bsnz24jx	590	29	progression	progression	NN
cord-280549-bsnz24jx	590	30	in	in	IN
cord-280549-bsnz24jx	590	31	G1-cyclin	G1-cyclin	NNP
cord-280549-bsnz24jx	590	32	-	-	HYPH
cord-280549-bsnz24jx	590	33	deficient	deficient	JJ
cord-280549-bsnz24jx	590	34	yeast	yeast	NN
cord-280549-bsnz24jx	591	1	(	(	-LRB-
cord-280549-bsnz24jx	591	2	LaPierre	LaPierre	NNP
cord-280549-bsnz24jx	591	3	et	et	NNP
cord-280549-bsnz24jx	591	4	al	al	NNP
cord-280549-bsnz24jx	591	5	.	.	NNP
cord-280549-bsnz24jx	591	6	,	,	,
cord-280549-bsnz24jx	591	7	1998	1998	CD
cord-280549-bsnz24jx	591	8	)	)	-RRB-
cord-280549-bsnz24jx	591	9	.	.	.
cord-280549-bsnz24jx	592	1	In	in	IN
cord-280549-bsnz24jx	592	2	addition	addition	NN
cord-280549-bsnz24jx	592	3	to	to	IN
cord-280549-bsnz24jx	592	4	sharing	share	VBG
cord-280549-bsnz24jx	592	5	sequence	sequence	NN
cord-280549-bsnz24jx	592	6	similarity	similarity	NN
cord-280549-bsnz24jx	592	7	with	with	IN
cord-280549-bsnz24jx	592	8	D	d	NN
cord-280549-bsnz24jx	592	9	-	-	HYPH
cord-280549-bsnz24jx	592	10	type	type	NN
cord-280549-bsnz24jx	592	11	cyclins	cyclin	NNS
cord-280549-bsnz24jx	592	12	,	,	,
cord-280549-bsnz24jx	592	13	WDSV	WDSV	NNP
cord-280549-bsnz24jx	592	14	rv	rv	NNP
cord-280549-bsnz24jx	592	15	-	-	HYPH
cord-280549-bsnz24jx	592	16	cyclin	cyclin	NNP
cord-280549-bsnz24jx	592	17	was	be	VBD
cord-280549-bsnz24jx	592	18	shown	show	VBN
cord-280549-bsnz24jx	592	19	to	to	TO
cord-280549-bsnz24jx	592	20	be	be	VB
cord-280549-bsnz24jx	592	21	a	a	DT
cord-280549-bsnz24jx	592	22	structural	structural	JJ
cord-280549-bsnz24jx	592	23	ortholog	ortholog	NN
cord-280549-bsnz24jx	592	24	of	of	IN
cord-280549-bsnz24jx	592	25	cyclin	cyclin	NNP
cord-280549-bsnz24jx	592	26	C	C	NNP
cord-280549-bsnz24jx	593	1	(	(	-LRB-
cord-280549-bsnz24jx	593	2	Brewster	Brewster	NNP
cord-280549-bsnz24jx	593	3	et	et	NNP
cord-280549-bsnz24jx	593	4	al	al	NNP
cord-280549-bsnz24jx	593	5	.	.	.
cord-280549-bsnz24jx	594	1	,	,	,
cord-280549-bsnz24jx	594	2	2011	2011	CD
cord-280549-bsnz24jx	594	3	)	)	-RRB-
cord-280549-bsnz24jx	594	4	,	,	,
cord-280549-bsnz24jx	594	5	which	which	WDT
cord-280549-bsnz24jx	594	6	was	be	VBD
cord-280549-bsnz24jx	594	7	identified	identify	VBN
cord-280549-bsnz24jx	594	8	owing	owe	VBG
cord-280549-bsnz24jx	594	9	to	to	IN
cord-280549-bsnz24jx	594	10	its	-PRON-	PRP$
cord-280549-bsnz24jx	594	11	ability	ability	NN
cord-280549-bsnz24jx	594	12	to	to	TO
cord-280549-bsnz24jx	594	13	rescue	rescue	VB
cord-280549-bsnz24jx	594	14	cyclin	cyclin	NN
cord-280549-bsnz24jx	594	15	G1	G1	NNP
cord-280549-bsnz24jx	594	16	function	function	NN
cord-280549-bsnz24jx	594	17	in	in	IN
cord-280549-bsnz24jx	594	18	yeast	yeast	NN
cord-280549-bsnz24jx	595	1	(	(	-LRB-
cord-280549-bsnz24jx	595	2	Huard	Huard	NNP
cord-280549-bsnz24jx	595	3	et	et	NNP
cord-280549-bsnz24jx	595	4	al	al	NNP
cord-280549-bsnz24jx	595	5	.	.	NNP
cord-280549-bsnz24jx	595	6	,	,	,
cord-280549-bsnz24jx	595	7	2008	2008	CD
cord-280549-bsnz24jx	595	8	)	)	-RRB-
cord-280549-bsnz24jx	595	9	.	.	.
cord-280549-bsnz24jx	596	1	Cyclin	Cyclin	NNP
cord-280549-bsnz24jx	596	2	C	C	NNP
cord-280549-bsnz24jx	596	3	has	have	VBZ
cord-280549-bsnz24jx	596	4	been	be	VBN
cord-280549-bsnz24jx	596	5	shown	show	VBN
cord-280549-bsnz24jx	596	6	to	to	TO
cord-280549-bsnz24jx	596	7	promote	promote	VB
cord-280549-bsnz24jx	596	8	G0	G0	NNP
cord-280549-bsnz24jx	596	9	/	/	SYM
cord-280549-bsnz24jx	596	10	G1	G1	NNP
cord-280549-bsnz24jx	596	11	transition	transition	NN
cord-280549-bsnz24jx	596	12	through	through	IN
cord-280549-bsnz24jx	596	13	phosphorylating	phosphorylate	VBG
cord-280549-bsnz24jx	596	14	Rb	Rb	NNP
cord-280549-bsnz24jx	596	15	in	in	IN
cord-280549-bsnz24jx	596	16	combination	combination	NN
cord-280549-bsnz24jx	596	17	with	with	IN
cord-280549-bsnz24jx	596	18	CDK3	CDK3	NNP
cord-280549-bsnz24jx	597	1	(	(	-LRB-
cord-280549-bsnz24jx	597	2	Lew	Lew	NNP
cord-280549-bsnz24jx	597	3	et	et	NNP
cord-280549-bsnz24jx	597	4	al	al	NNP
cord-280549-bsnz24jx	597	5	.	.	NNP
cord-280549-bsnz24jx	597	6	,	,	,
cord-280549-bsnz24jx	597	7	1991	1991	CD
cord-280549-bsnz24jx	597	8	;	;	:
cord-280549-bsnz24jx	598	1	Ren	Ren	NNP
cord-280549-bsnz24jx	598	2	and	and	CC
cord-280549-bsnz24jx	598	3	Rollins	Rollins	NNP
cord-280549-bsnz24jx	598	4	,	,	,
cord-280549-bsnz24jx	598	5	2004	2004	CD
cord-280549-bsnz24jx	598	6	)	)	-RRB-
cord-280549-bsnz24jx	598	7	and	and	CC
cord-280549-bsnz24jx	598	8	was	be	VBD
cord-280549-bsnz24jx	598	9	later	later	RB
cord-280549-bsnz24jx	598	10	recognized	recognize	VBN
cord-280549-bsnz24jx	598	11	as	as	IN
cord-280549-bsnz24jx	598	12	part	part	NN
cord-280549-bsnz24jx	598	13	of	of	IN
cord-280549-bsnz24jx	598	14	the	the	DT
cord-280549-bsnz24jx	598	15	Mediator	Mediator	NNP
cord-280549-bsnz24jx	598	16	complex	complex	NN
cord-280549-bsnz24jx	598	17	,	,	,
cord-280549-bsnz24jx	598	18	which	which	WDT
cord-280549-bsnz24jx	598	19	links	link	VBZ
cord-280549-bsnz24jx	598	20	gene	gene	NN
cord-280549-bsnz24jx	598	21	-	-	HYPH
cord-280549-bsnz24jx	598	22	specific	specific	JJ
cord-280549-bsnz24jx	598	23	activators	activator	NNS
cord-280549-bsnz24jx	598	24	to	to	IN
cord-280549-bsnz24jx	598	25	the	the	DT
cord-280549-bsnz24jx	598	26	general	general	JJ
cord-280549-bsnz24jx	598	27	RNA	RNA	NNP
cord-280549-bsnz24jx	598	28	Pol	Pol	NNP
cord-280549-bsnz24jx	598	29	II	II	NNP
cord-280549-bsnz24jx	598	30	transcription	transcription	NN
cord-280549-bsnz24jx	598	31	machinery	machinery	NN
cord-280549-bsnz24jx	598	32	,	,	,
cord-280549-bsnz24jx	598	33	in	in	IN
cord-280549-bsnz24jx	598	34	complex	complex	NN
cord-280549-bsnz24jx	598	35	with	with	IN
cord-280549-bsnz24jx	598	36	CDK8	CDK8	NNP
cord-280549-bsnz24jx	598	37	Conaway	Conaway	NNP
cord-280549-bsnz24jx	598	38	and	and	CC
cord-280549-bsnz24jx	598	39	Conaway	Conaway	NNP
cord-280549-bsnz24jx	598	40	,	,	,
cord-280549-bsnz24jx	598	41	2011	2011	CD
cord-280549-bsnz24jx	598	42	;	;	:
cord-280549-bsnz24jx	598	43	Malumbres	malumbre	NNS
cord-280549-bsnz24jx	598	44	,	,	,
cord-280549-bsnz24jx	598	45	2014	2014	CD
cord-280549-bsnz24jx	598	46	)	)	-RRB-
cord-280549-bsnz24jx	598	47	.	.	.
cord-280549-bsnz24jx	599	1	As	as	IN
cord-280549-bsnz24jx	599	2	expected	expect	VBN
cord-280549-bsnz24jx	599	3	,	,	,
cord-280549-bsnz24jx	599	4	WDSV	WDSV	NNP
cord-280549-bsnz24jx	599	5	rv	rv	NNP
cord-280549-bsnz24jx	599	6	-	-	HYPH
cord-280549-bsnz24jx	599	7	cyclin	cyclin	NNP
cord-280549-bsnz24jx	599	8	has	have	VBZ
cord-280549-bsnz24jx	599	9	been	be	VBN
cord-280549-bsnz24jx	599	10	shown	show	VBN
cord-280549-bsnz24jx	599	11	to	to	TO
cord-280549-bsnz24jx	599	12	interact	interact	VB
cord-280549-bsnz24jx	599	13	with	with	IN
cord-280549-bsnz24jx	599	14	either	either	CC
cord-280549-bsnz24jx	599	15	CDK8	CDK8	NNP
cord-280549-bsnz24jx	599	16	,	,	,
cord-280549-bsnz24jx	599	17	component	component	NN
cord-280549-bsnz24jx	599	18	of	of	IN
cord-280549-bsnz24jx	599	19	the	the	DT
cord-280549-bsnz24jx	599	20	Mediator	Mediator	NNP
cord-280549-bsnz24jx	599	21	complex	complex	NN
cord-280549-bsnz24jx	599	22	(	(	-LRB-
cord-280549-bsnz24jx	599	23	Rovnak	Rovnak	NNP
cord-280549-bsnz24jx	599	24	and	and	CC
cord-280549-bsnz24jx	599	25	Quackenbush	Quackenbush	NNP
cord-280549-bsnz24jx	599	26	,	,	,
cord-280549-bsnz24jx	599	27	2002	2002	CD
cord-280549-bsnz24jx	599	28	;	;	:
cord-280549-bsnz24jx	599	29	Poss	Poss	NNP
cord-280549-bsnz24jx	599	30	et	et	NNP
cord-280549-bsnz24jx	599	31	al	al	NNP
cord-280549-bsnz24jx	599	32	.	.	NNP
cord-280549-bsnz24jx	599	33	,	,	,
cord-280549-bsnz24jx	599	34	2013	2013	CD
cord-280549-bsnz24jx	599	35	)	)	-RRB-
cord-280549-bsnz24jx	599	36	,	,	,
cord-280549-bsnz24jx	599	37	or	or	CC
cord-280549-bsnz24jx	599	38	CDK3	CDK3	NNP
cord-280549-bsnz24jx	599	39	,	,	,
cord-280549-bsnz24jx	599	40	leading	lead	VBG
cord-280549-bsnz24jx	599	41	to	to	IN
cord-280549-bsnz24jx	599	42	enhanced	enhanced	JJ
cord-280549-bsnz24jx	599	43	host	host	NN
cord-280549-bsnz24jx	599	44	gene	gene	NN
cord-280549-bsnz24jx	599	45	expression	expression	NN
cord-280549-bsnz24jx	599	46	or	or	CC
cord-280549-bsnz24jx	599	47	cell	cell	NN
cord-280549-bsnz24jx	599	48	proliferation	proliferation	NN
cord-280549-bsnz24jx	599	49	without	without	IN
cord-280549-bsnz24jx	599	50	serum	serum	NN
cord-280549-bsnz24jx	599	51	stimulation	stimulation	NN
cord-280549-bsnz24jx	599	52	,	,	,
cord-280549-bsnz24jx	599	53	respectively	respectively	RB
cord-280549-bsnz24jx	599	54	(	(	-LRB-
cord-280549-bsnz24jx	599	55	Brewster	Brewster	NNP
cord-280549-bsnz24jx	599	56	et	et	NNP
cord-280549-bsnz24jx	599	57	al	al	NNP
cord-280549-bsnz24jx	599	58	.	.	NNP
cord-280549-bsnz24jx	599	59	,	,	,
cord-280549-bsnz24jx	599	60	2011	2011	CD
cord-280549-bsnz24jx	599	61	)	)	-RRB-
cord-280549-bsnz24jx	599	62	.	.	.
cord-280549-bsnz24jx	600	1	Other	other	JJ
cord-280549-bsnz24jx	600	2	viruses	virus	NNS
cord-280549-bsnz24jx	600	3	have	have	VBP
cord-280549-bsnz24jx	600	4	been	be	VBN
cord-280549-bsnz24jx	600	5	shown	show	VBN
cord-280549-bsnz24jx	600	6	to	to	TO
cord-280549-bsnz24jx	600	7	interact	interact	VB
cord-280549-bsnz24jx	600	8	with	with	IN
cord-280549-bsnz24jx	600	9	subunits	subunit	NNS
cord-280549-bsnz24jx	600	10	of	of	IN
cord-280549-bsnz24jx	600	11	the	the	DT
cord-280549-bsnz24jx	600	12	Mediator	Mediator	NNP
cord-280549-bsnz24jx	600	13	complex	complex	NN
cord-280549-bsnz24jx	600	14	,	,	,
cord-280549-bsnz24jx	600	15	but	but	CC
cord-280549-bsnz24jx	600	16	they	-PRON-	PRP
cord-280549-bsnz24jx	600	17	are	be	VBP
cord-280549-bsnz24jx	600	18	doing	do	VBG
cord-280549-bsnz24jx	600	19	so	so	RB
cord-280549-bsnz24jx	600	20	independently	independently	RB
cord-280549-bsnz24jx	600	21	of	of	IN
cord-280549-bsnz24jx	600	22	viral	viral	JJ
cord-280549-bsnz24jx	600	23	cyclins	cyclin	NNS
cord-280549-bsnz24jx	600	24	.	.	.
cord-280549-bsnz24jx	601	1	For	for	IN
cord-280549-bsnz24jx	601	2	example	example	NN
cord-280549-bsnz24jx	601	3	,	,	,
cord-280549-bsnz24jx	601	4	varicella	varicella	NN
cord-280549-bsnz24jx	601	5	-	-	HYPH
cord-280549-bsnz24jx	601	6	zoster	zoster	NN
cord-280549-bsnz24jx	601	7	virus	virus	NN
cord-280549-bsnz24jx	601	8	(	(	-LRB-
cord-280549-bsnz24jx	601	9	VZV	VZV	NNP
cord-280549-bsnz24jx	601	10	)	)	-RRB-
cord-280549-bsnz24jx	601	11	,	,	,
cord-280549-bsnz24jx	601	12	an	an	DT
cord-280549-bsnz24jx	601	13	alpha	alpha	NN
cord-280549-bsnz24jx	601	14	-	-	HYPH
cord-280549-bsnz24jx	601	15	herpes	herpes	NN
cord-280549-bsnz24jx	601	16	virus	virus	NN
cord-280549-bsnz24jx	601	17	that	that	WDT
cord-280549-bsnz24jx	601	18	causes	cause	VBZ
cord-280549-bsnz24jx	601	19	varicella	varicella	NN
cord-280549-bsnz24jx	601	20	and	and	CC
cord-280549-bsnz24jx	601	21	zoster	zoster	NN
cord-280549-bsnz24jx	601	22	,	,	,
cord-280549-bsnz24jx	601	23	targets	target	VBZ
cord-280549-bsnz24jx	601	24	the	the	DT
cord-280549-bsnz24jx	601	25	MED25	MED25	NNP
cord-280549-bsnz24jx	601	26	subunit	subunit	NN
cord-280549-bsnz24jx	601	27	of	of	IN
cord-280549-bsnz24jx	601	28	Mediator	Mediator	NNP
cord-280549-bsnz24jx	601	29	through	through	IN
cord-280549-bsnz24jx	601	30	its	-PRON-	PRP$
cord-280549-bsnz24jx	601	31	major	major	JJ
cord-280549-bsnz24jx	601	32	transactivator	transactivator	NN
cord-280549-bsnz24jx	601	33	protein	protein	NN
cord-280549-bsnz24jx	601	34	,	,	,
cord-280549-bsnz24jx	601	35	immediate	immediate	JJ
cord-280549-bsnz24jx	601	36	early	early	JJ
cord-280549-bsnz24jx	601	37	gene	gene	NN
cord-280549-bsnz24jx	601	38	62	62	CD
cord-280549-bsnz24jx	601	39	(	(	-LRB-
cord-280549-bsnz24jx	601	40	IE62	IE62	NNP
cord-280549-bsnz24jx	601	41	)	)	-RRB-
cord-280549-bsnz24jx	601	42	,	,	,
cord-280549-bsnz24jx	601	43	whereas	whereas	IN
cord-280549-bsnz24jx	601	44	herpes	herpes	NNP
cord-280549-bsnz24jx	601	45	simplex	simplex	NNP
cord-280549-bsnz24jx	601	46	virus	virus	NN
cord-280549-bsnz24jx	601	47	utilizes	utilize	VBZ
cord-280549-bsnz24jx	601	48	VP16	VP16	NNP
cord-280549-bsnz24jx	601	49	,	,	,
cord-280549-bsnz24jx	601	50	which	which	WDT
cord-280549-bsnz24jx	601	51	controls	control	VBZ
cord-280549-bsnz24jx	601	52	the	the	DT
cord-280549-bsnz24jx	601	53	transcription	transcription	NN
cord-280549-bsnz24jx	601	54	of	of	IN
cord-280549-bsnz24jx	601	55	immediate	immediate	JJ
cord-280549-bsnz24jx	601	56	early	early	JJ
cord-280549-bsnz24jx	601	57	genes	gene	NNS
cord-280549-bsnz24jx	601	58	,	,	,
cord-280549-bsnz24jx	601	59	to	to	TO
cord-280549-bsnz24jx	601	60	activate	activate	VB
cord-280549-bsnz24jx	601	61	transcription	transcription	NN
cord-280549-bsnz24jx	601	62	through	through	IN
cord-280549-bsnz24jx	601	63	a	a	DT
cord-280549-bsnz24jx	601	64	specific	specific	JJ
cord-280549-bsnz24jx	601	65	MED25-associated	med25-associated	JJ
cord-280549-bsnz24jx	601	66	mediator	mediator	NN
cord-280549-bsnz24jx	601	67	deficient	deficient	JJ
cord-280549-bsnz24jx	601	68	in	in	IN
cord-280549-bsnz24jx	601	69	CDK8	CDK8	NNP
cord-280549-bsnz24jx	602	1	(	(	-LRB-
cord-280549-bsnz24jx	602	2	Uhlmann	Uhlmann	NNP
cord-280549-bsnz24jx	602	3	et	et	NNP
cord-280549-bsnz24jx	602	4	al	al	NNP
cord-280549-bsnz24jx	602	5	.	.	NNP
cord-280549-bsnz24jx	602	6	,	,	,
cord-280549-bsnz24jx	602	7	2007	2007	CD
cord-280549-bsnz24jx	602	8	)	)	-RRB-
cord-280549-bsnz24jx	602	9	.	.	.
cord-280549-bsnz24jx	603	1	Interestingly	interestingly	RB
cord-280549-bsnz24jx	603	2	,	,	,
cord-280549-bsnz24jx	603	3	it	-PRON-	PRP
cord-280549-bsnz24jx	603	4	was	be	VBD
cord-280549-bsnz24jx	603	5	later	later	RB
cord-280549-bsnz24jx	603	6	found	find	VBN
cord-280549-bsnz24jx	603	7	that	that	IN
cord-280549-bsnz24jx	603	8	CDK8	CDK8	NNP
cord-280549-bsnz24jx	603	9	could	could	MD
cord-280549-bsnz24jx	603	10	positively	positively	RB
cord-280549-bsnz24jx	603	11	regulate	regulate	VB
cord-280549-bsnz24jx	603	12	VP16-dependent	vp16-dependent	CD
cord-280549-bsnz24jx	603	13	transcriptional	transcriptional	JJ
cord-280549-bsnz24jx	603	14	regulation	regulation	NN
cord-280549-bsnz24jx	603	15	,	,	,
cord-280549-bsnz24jx	603	16	while	while	IN
cord-280549-bsnz24jx	603	17	CDK11	CDK11	NNP
cord-280549-bsnz24jx	603	18	and	and	CC
cord-280549-bsnz24jx	603	19	CDK19	CDK19	NNP
cord-280549-bsnz24jx	603	20	exhibit	exhibit	VB
cord-280549-bsnz24jx	603	21	opposing	oppose	VBG
cord-280549-bsnz24jx	603	22	roles	role	NNS
cord-280549-bsnz24jx	604	1	(	(	-LRB-
cord-280549-bsnz24jx	604	2	Furumoto	Furumoto	NNP
cord-280549-bsnz24jx	604	3	et	et	NNP
cord-280549-bsnz24jx	604	4	al	al	NNP
cord-280549-bsnz24jx	604	5	.	.	NNP
cord-280549-bsnz24jx	604	6	,	,	,
cord-280549-bsnz24jx	604	7	2007	2007	CD
cord-280549-bsnz24jx	604	8	;	;	:
cord-280549-bsnz24jx	604	9	Tsutsui	Tsutsui	NNP
cord-280549-bsnz24jx	604	10	et	et	FW
cord-280549-bsnz24jx	604	11	al	al	NNP
cord-280549-bsnz24jx	604	12	.	.	NNP
cord-280549-bsnz24jx	604	13	,	,	,
cord-280549-bsnz24jx	605	1	2008	2008	CD
cord-280549-bsnz24jx	606	1	Tsutsui	Tsutsui	NNP
cord-280549-bsnz24jx	606	2	et	et	FW
cord-280549-bsnz24jx	606	3	al	al	NNP
cord-280549-bsnz24jx	606	4	.	.	NNP
cord-280549-bsnz24jx	606	5	,	,	,
cord-280549-bsnz24jx	606	6	,	,	,
cord-280549-bsnz24jx	606	7	2011	2011	CD
cord-280549-bsnz24jx	606	8	.	.	.
cord-280549-bsnz24jx	607	1	Sequence	sequence	NN
cord-280549-bsnz24jx	607	2	analysis	analysis	NN
cord-280549-bsnz24jx	607	3	of	of	IN
cord-280549-bsnz24jx	607	4	available	available	JJ
cord-280549-bsnz24jx	607	5	poxvirus	poxvirus	NNP
cord-280549-bsnz24jx	607	6	genome	genome	NNP
cord-280549-bsnz24jx	607	7	has	have	VBZ
cord-280549-bsnz24jx	607	8	revealed	reveal	VBN
cord-280549-bsnz24jx	607	9	that	that	IN
cord-280549-bsnz24jx	607	10	both	both	CC
cord-280549-bsnz24jx	607	11	crocodile	crocodile	NN
cord-280549-bsnz24jx	607	12	and	and	CC
cord-280549-bsnz24jx	607	13	squirrel	squirrel	NN
cord-280549-bsnz24jx	607	14	poxviruses	poxvirus	NNS
cord-280549-bsnz24jx	607	15	encode	encode	VBP
cord-280549-bsnz24jx	607	16	a	a	DT
cord-280549-bsnz24jx	607	17	RING	ring	NN
cord-280549-bsnz24jx	607	18	-	-	HYPH
cord-280549-bsnz24jx	607	19	H2	H2	NNP
cord-280549-bsnz24jx	607	20	protein	protein	NN
cord-280549-bsnz24jx	607	21	,	,	,
cord-280549-bsnz24jx	607	22	the	the	DT
cord-280549-bsnz24jx	607	23	poxvirus	poxvirus	NNP
cord-280549-bsnz24jx	607	24	APC	APC	NNP
cord-280549-bsnz24jx	607	25	/	/	SYM
cord-280549-bsnz24jx	607	26	cyclosome	cyclosome	NN
cord-280549-bsnz24jx	607	27	regulator	regulator	NN
cord-280549-bsnz24jx	607	28	(	(	-LRB-
cord-280549-bsnz24jx	607	29	PACR),which	PACR),which	NNP
cord-280549-bsnz24jx	607	30	shares	share	NNS
cord-280549-bsnz24jx	607	31	sequence	sequence	NN
cord-280549-bsnz24jx	607	32	similarities	similarity	NNS
cord-280549-bsnz24jx	607	33	to	to	IN
cord-280549-bsnz24jx	607	34	the	the	DT
cord-280549-bsnz24jx	607	35	APC	APC	NNP
cord-280549-bsnz24jx	607	36	subunit	subunit	NN
cord-280549-bsnz24jx	607	37	11	11	CD
cord-280549-bsnz24jx	607	38	(	(	-LRB-
cord-280549-bsnz24jx	607	39	APC11	APC11	NNP
cord-280549-bsnz24jx	607	40	)	)	-RRB-
cord-280549-bsnz24jx	607	41	.	.	.
cord-280549-bsnz24jx	608	1	Together	together	RB
cord-280549-bsnz24jx	608	2	with	with	IN
cord-280549-bsnz24jx	608	3	the	the	DT
cord-280549-bsnz24jx	608	4	scaffold	scaffold	NN
cord-280549-bsnz24jx	608	5	protein	protein	NN
cord-280549-bsnz24jx	608	6	APC2	APC2	NNP
cord-280549-bsnz24jx	608	7	,	,	,
cord-280549-bsnz24jx	608	8	APC11	APC11	NNP
cord-280549-bsnz24jx	608	9	forms	form	VBZ
cord-280549-bsnz24jx	608	10	the	the	DT
cord-280549-bsnz24jx	608	11	catalytic	catalytic	JJ
cord-280549-bsnz24jx	608	12	core	core	NN
cord-280549-bsnz24jx	608	13	of	of	IN
cord-280549-bsnz24jx	608	14	APC	APC	NNP
cord-280549-bsnz24jx	608	15	/	/	SYM
cord-280549-bsnz24jx	608	16	C	C	NNP
cord-280549-bsnz24jx	608	17	,	,	,
cord-280549-bsnz24jx	608	18	which	which	WDT
cord-280549-bsnz24jx	608	19	regulates	regulate	VBZ
cord-280549-bsnz24jx	608	20	the	the	DT
cord-280549-bsnz24jx	608	21	progression	progression	NN
cord-280549-bsnz24jx	608	22	through	through	IN
cord-280549-bsnz24jx	608	23	mitosis	mitosis	NN
cord-280549-bsnz24jx	608	24	by	by	IN
cord-280549-bsnz24jx	608	25	targeting	target	VBG
cord-280549-bsnz24jx	608	26	several	several	JJ
cord-280549-bsnz24jx	608	27	anaphase	anaphase	VB
cord-280549-bsnz24jx	608	28	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	608	29	proteins	protein	NNS
cord-280549-bsnz24jx	608	30	for	for	IN
cord-280549-bsnz24jx	608	31	proteolysis	proteolysis	NN
cord-280549-bsnz24jx	608	32	and	and	CC
cord-280549-bsnz24jx	608	33	the	the	DT
cord-280549-bsnz24jx	608	34	maintenance	maintenance	NN
cord-280549-bsnz24jx	608	35	of	of	IN
cord-280549-bsnz24jx	608	36	G1	G1	NNP
cord-280549-bsnz24jx	608	37	phase	phase	NN
cord-280549-bsnz24jx	608	38	(	(	-LRB-
cord-280549-bsnz24jx	608	39	Tang	Tang	NNP
cord-280549-bsnz24jx	608	40	et	et	FW
cord-280549-bsnz24jx	608	41	al	al	NNP
cord-280549-bsnz24jx	608	42	.	.	NNP
cord-280549-bsnz24jx	608	43	,	,	,
cord-280549-bsnz24jx	608	44	2001	2001	CD
cord-280549-bsnz24jx	608	45	;	;	:
cord-280549-bsnz24jx	608	46	Hsu	Hsu	NNP
cord-280549-bsnz24jx	608	47	et	et	NNP
cord-280549-bsnz24jx	608	48	al	al	NNP
cord-280549-bsnz24jx	608	49	.	.	NNP
cord-280549-bsnz24jx	608	50	,	,	,
cord-280549-bsnz24jx	608	51	2002	2002	CD
cord-280549-bsnz24jx	608	52	;	;	:
cord-280549-bsnz24jx	609	1	Song	Song	NNP
cord-280549-bsnz24jx	609	2	et	et	FW
cord-280549-bsnz24jx	609	3	al	al	NNP
cord-280549-bsnz24jx	609	4	.	.	NNP
cord-280549-bsnz24jx	609	5	,	,	,
cord-280549-bsnz24jx	609	6	2004	2004	CD
cord-280549-bsnz24jx	610	1	;	;	:
cord-280549-bsnz24jx	610	2	Wei	Wei	NNP
cord-280549-bsnz24jx	610	3	et	et	NNP
cord-280549-bsnz24jx	610	4	al	al	NNP
cord-280549-bsnz24jx	610	5	.	.	NNP
cord-280549-bsnz24jx	610	6	,	,	,
cord-280549-bsnz24jx	610	7	2004	2004	CD
cord-280549-bsnz24jx	610	8	;	;	:
cord-280549-bsnz24jx	610	9	Wehman	Wehman	NNP
cord-280549-bsnz24jx	610	10	et	et	NNP
cord-280549-bsnz24jx	610	11	al	al	NNP
cord-280549-bsnz24jx	610	12	.	.	NNP
cord-280549-bsnz24jx	610	13	,	,	,
cord-280549-bsnz24jx	610	14	2007	2007	CD
cord-280549-bsnz24jx	610	15	;	;	:
cord-280549-bsnz24jx	610	16	Mo	Mo	NNP
cord-280549-bsnz24jx	610	17	et	et	NNP
cord-280549-bsnz24jx	610	18	al	al	NNP
cord-280549-bsnz24jx	610	19	.	.	NNP
cord-280549-bsnz24jx	610	20	,	,	,
cord-280549-bsnz24jx	610	21	2009	2009	CD
cord-280549-bsnz24jx	610	22	)	)	-RRB-
cord-280549-bsnz24jx	610	23	.	.	.
cord-280549-bsnz24jx	611	1	Interestingly	interestingly	RB
cord-280549-bsnz24jx	611	2	,	,	,
cord-280549-bsnz24jx	611	3	PACR	PACR	NNP
cord-280549-bsnz24jx	611	4	mimics	mimic	VBZ
cord-280549-bsnz24jx	611	5	the	the	DT
cord-280549-bsnz24jx	611	6	binding	binding	JJ
cord-280549-bsnz24jx	611	7	ability	ability	NN
cord-280549-bsnz24jx	611	8	of	of	IN
cord-280549-bsnz24jx	611	9	APC11	APC11	NNP
cord-280549-bsnz24jx	611	10	to	to	IN
cord-280549-bsnz24jx	611	11	APC2	apc2	NN
cord-280549-bsnz24jx	612	1	but	but	CC
cord-280549-bsnz24jx	612	2	not	not	RB
cord-280549-bsnz24jx	612	3	the	the	DT
cord-280549-bsnz24jx	612	4	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	612	5	ligase	ligase	NN
cord-280549-bsnz24jx	612	6	activity	activity	NN
cord-280549-bsnz24jx	612	7	of	of	IN
cord-280549-bsnz24jx	612	8	APC11	APC11	NNP
cord-280549-bsnz24jx	612	9	.	.	.
cord-280549-bsnz24jx	613	1	Expression	expression	NN
cord-280549-bsnz24jx	613	2	of	of	IN
cord-280549-bsnz24jx	613	3	PACR	PACR	NNP
cord-280549-bsnz24jx	613	4	impairs	impair	VBZ
cord-280549-bsnz24jx	613	5	APC	APC	NNP
cord-280549-bsnz24jx	613	6	/	/	SYM
cord-280549-bsnz24jx	613	7	C	C	NNP
cord-280549-bsnz24jx	613	8	function	function	NN
cord-280549-bsnz24jx	613	9	,	,	,
cord-280549-bsnz24jx	613	10	accompanied	accompany	VBN
cord-280549-bsnz24jx	613	11	by	by	IN
cord-280549-bsnz24jx	613	12	the	the	DT
cord-280549-bsnz24jx	613	13	accumulation	accumulation	NN
cord-280549-bsnz24jx	613	14	of	of	IN
cord-280549-bsnz24jx	613	15	cells	cell	NNS
cord-280549-bsnz24jx	613	16	in	in	IN
cord-280549-bsnz24jx	613	17	G2	G2	NNP
cord-280549-bsnz24jx	613	18	/	/	SYM
cord-280549-bsnz24jx	613	19	M	M	NNP
cord-280549-bsnz24jx	613	20	phase	phase	NN
cord-280549-bsnz24jx	613	21	.	.	.
cord-280549-bsnz24jx	614	1	The	the	DT
cord-280549-bsnz24jx	614	2	cell	cell	NN
cord-280549-bsnz24jx	614	3	cycle	cycle	NN
cord-280549-bsnz24jx	614	4	perturbation	perturbation	NN
cord-280549-bsnz24jx	614	5	effect	effect	NN
cord-280549-bsnz24jx	614	6	of	of	IN
cord-280549-bsnz24jx	614	7	PACR	PACR	NNP
cord-280549-bsnz24jx	614	8	requires	require	VBZ
cord-280549-bsnz24jx	614	9	its	-PRON-	PRP$
cord-280549-bsnz24jx	614	10	N	n	CD
cord-280549-bsnz24jx	614	11	-	-	HYPH
cord-280549-bsnz24jx	614	12	terminal	terminal	NN
cord-280549-bsnz24jx	614	13	region	region	NN
cord-280549-bsnz24jx	614	14	,	,	,
cord-280549-bsnz24jx	614	15	which	which	WDT
cord-280549-bsnz24jx	614	16	is	be	VBZ
cord-280549-bsnz24jx	614	17	also	also	RB
cord-280549-bsnz24jx	614	18	the	the	DT
cord-280549-bsnz24jx	614	19	region	region	NN
cord-280549-bsnz24jx	614	20	responsible	responsible	JJ
cord-280549-bsnz24jx	614	21	for	for	IN
cord-280549-bsnz24jx	614	22	association	association	NN
cord-280549-bsnz24jx	614	23	with	with	IN
cord-280549-bsnz24jx	614	24	APC2	APC2	NNP
cord-280549-bsnz24jx	615	1	(	(	-LRB-
cord-280549-bsnz24jx	615	2	Mo	Mo	NNP
cord-280549-bsnz24jx	615	3	et	et	NNP
cord-280549-bsnz24jx	615	4	al	al	NNP
cord-280549-bsnz24jx	615	5	.	.	NNP
cord-280549-bsnz24jx	615	6	,	,	,
cord-280549-bsnz24jx	615	7	2009	2009	CD
cord-280549-bsnz24jx	615	8	)	)	-RRB-
cord-280549-bsnz24jx	615	9	.	.	.
cord-280549-bsnz24jx	616	1	Thus	thus	RB
cord-280549-bsnz24jx	616	2	,	,	,
cord-280549-bsnz24jx	616	3	poxvirus	poxvirus	NNP
cord-280549-bsnz24jx	616	4	hinders	hinder	VBZ
cord-280549-bsnz24jx	616	5	normal	normal	JJ
cord-280549-bsnz24jx	616	6	cell	cell	NN
cord-280549-bsnz24jx	616	7	cycle	cycle	NN
cord-280549-bsnz24jx	616	8	progression	progression	NN
cord-280549-bsnz24jx	616	9	by	by	IN
cord-280549-bsnz24jx	616	10	encoding	encode	VBG
cord-280549-bsnz24jx	616	11	an	an	DT
cord-280549-bsnz24jx	616	12	inactive	inactive	JJ
cord-280549-bsnz24jx	616	13	homolog	homolog	NN
cord-280549-bsnz24jx	616	14	of	of	IN
cord-280549-bsnz24jx	616	15	APC11	APC11	NNP
cord-280549-bsnz24jx	616	16	.	.	.
cord-280549-bsnz24jx	617	1	(	(	-LRB-
cord-280549-bsnz24jx	617	2	TABLE	TABLE	NNP
cord-280549-bsnz24jx	617	3	6	6	CD
cord-280549-bsnz24jx	617	4	)	)	-RRB-
cord-280549-bsnz24jx	618	1	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	618	2	Vpr	Vpr	NNP
cord-280549-bsnz24jx	618	3	-	-	HYPH
cord-280549-bsnz24jx	618	4	induced	induce	VBN
cord-280549-bsnz24jx	618	5	G2	G2	NNP
cord-280549-bsnz24jx	618	6	arrest	arrest	NN
cord-280549-bsnz24jx	618	7	depends	depend	VBZ
cord-280549-bsnz24jx	618	8	on	on	IN
cord-280549-bsnz24jx	618	9	the	the	DT
cord-280549-bsnz24jx	618	10	activation	activation	NN
cord-280549-bsnz24jx	618	11	of	of	IN
cord-280549-bsnz24jx	618	12	ATR	ATR	NNP
cord-280549-bsnz24jx	618	13	,	,	,
cord-280549-bsnz24jx	618	14	the	the	DT
cord-280549-bsnz24jx	618	15	ataxia	ataxia	NN
cord-280549-bsnz24jx	618	16	telangiectasia	telangiectasia	NNP
cord-280549-bsnz24jx	618	17	mutated	mutate	VBD
cord-280549-bsnz24jx	618	18	(	(	-LRB-
cord-280549-bsnz24jx	618	19	ATM)-and	atm)-and	NN
cord-280549-bsnz24jx	619	1	Rad3-related	Rad3-related	NNP
cord-280549-bsnz24jx	619	2	protein	protein	NN
cord-280549-bsnz24jx	619	3	,	,	,
cord-280549-bsnz24jx	619	4	which	which	WDT
cord-280549-bsnz24jx	619	5	phosphorylates	phosphorylate	VBZ
cord-280549-bsnz24jx	619	6	Chk1	Chk1	NNP
cord-280549-bsnz24jx	619	7	and	and	CC
cord-280549-bsnz24jx	619	8	,	,	,
cord-280549-bsnz24jx	619	9	in	in	IN
cord-280549-bsnz24jx	619	10	turn	turn	NN
cord-280549-bsnz24jx	619	11	,	,	,
cord-280549-bsnz24jx	619	12	leads	lead	VBZ
cord-280549-bsnz24jx	619	13	to	to	IN
cord-280549-bsnz24jx	619	14	both	both	DT
cord-280549-bsnz24jx	619	15	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	619	16	-	-	HYPH
cord-280549-bsnz24jx	619	17	induced	induce	VBN
cord-280549-bsnz24jx	619	18	degradation	degradation	NN
cord-280549-bsnz24jx	619	19	of	of	IN
cord-280549-bsnz24jx	619	20	Cdc25A	Cdc25A	NNP
cord-280549-bsnz24jx	619	21	and	and	CC
cord-280549-bsnz24jx	619	22	Cdc25C	Cdc25C	NNP
cord-280549-bsnz24jx	619	23	cytosolic	cytosolic	JJ
cord-280549-bsnz24jx	619	24	sequestration	sequestration	NN
cord-280549-bsnz24jx	620	1	(	(	-LRB-
cord-280549-bsnz24jx	620	2	Peng	Peng	NNP
cord-280549-bsnz24jx	620	3	et	et	NNP
cord-280549-bsnz24jx	620	4	al	al	NNP
cord-280549-bsnz24jx	620	5	.	.	NNP
cord-280549-bsnz24jx	620	6	,	,	,
cord-280549-bsnz24jx	620	7	1997	1997	CD
cord-280549-bsnz24jx	620	8	;	;	.
cord-280549-bsnz24jx	621	1	Sanchez	Sanchez	NNP
cord-280549-bsnz24jx	621	2	et	et	NNP
cord-280549-bsnz24jx	621	3	al	al	NNP
cord-280549-bsnz24jx	621	4	.	.	NNP
cord-280549-bsnz24jx	621	5	,	,	,
cord-280549-bsnz24jx	621	6	1997	1997	CD
cord-280549-bsnz24jx	621	7	;	;	:
cord-280549-bsnz24jx	621	8	Zhao	Zhao	NNP
cord-280549-bsnz24jx	621	9	and	and	CC
cord-280549-bsnz24jx	621	10	Piwnica	Piwnica	NNP
cord-280549-bsnz24jx	621	11	-	-	HYPH
cord-280549-bsnz24jx	621	12	Worms	Worms	NNPS
cord-280549-bsnz24jx	621	13	,	,	,
cord-280549-bsnz24jx	621	14	2001	2001	CD
cord-280549-bsnz24jx	621	15	;	;	:
cord-280549-bsnz24jx	621	16	Zhao	Zhao	NNP
cord-280549-bsnz24jx	621	17	et	et	NNP
cord-280549-bsnz24jx	621	18	al	al	NNP
cord-280549-bsnz24jx	621	19	.	.	NNP
cord-280549-bsnz24jx	621	20	,	,	,
cord-280549-bsnz24jx	621	21	2002	2002	CD
cord-280549-bsnz24jx	621	22	;	;	:
cord-280549-bsnz24jx	621	23	Roshal	Roshal	NNP
cord-280549-bsnz24jx	621	24	et	et	FW
cord-280549-bsnz24jx	621	25	al	al	NNP
cord-280549-bsnz24jx	621	26	.	.	NNP
cord-280549-bsnz24jx	621	27	,	,	,
cord-280549-bsnz24jx	621	28	2003	2003	CD
cord-280549-bsnz24jx	621	29	)	)	-RRB-
cord-280549-bsnz24jx	621	30	.	.	.
cord-280549-bsnz24jx	622	1	It	-PRON-	PRP
cord-280549-bsnz24jx	622	2	has	have	VBZ
cord-280549-bsnz24jx	622	3	been	be	VBN
cord-280549-bsnz24jx	622	4	proposed	propose	VBN
cord-280549-bsnz24jx	622	5	that	that	IN
cord-280549-bsnz24jx	622	6	the	the	DT
cord-280549-bsnz24jx	622	7	activation	activation	NN
cord-280549-bsnz24jx	622	8	of	of	IN
cord-280549-bsnz24jx	622	9	ATR	ATR	NNP
cord-280549-bsnz24jx	622	10	-	-	HYPH
cord-280549-bsnz24jx	622	11	dependent	dependent	JJ
cord-280549-bsnz24jx	622	12	DNA	dna	NN
cord-280549-bsnz24jx	622	13	damage	damage	NN
cord-280549-bsnz24jx	622	14	G2	G2	NNP
cord-280549-bsnz24jx	622	15	/	/	SYM
cord-280549-bsnz24jx	622	16	M	m	CD
cord-280549-bsnz24jx	622	17	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	622	18	by	by	IN
cord-280549-bsnz24jx	622	19	Vpr	Vpr	NNP
cord-280549-bsnz24jx	622	20	involves	involve	VBZ
cord-280549-bsnz24jx	622	21	the	the	DT
cord-280549-bsnz24jx	622	22	direct	direct	JJ
cord-280549-bsnz24jx	622	23	binding	binding	NN
cord-280549-bsnz24jx	622	24	of	of	IN
cord-280549-bsnz24jx	622	25	this	this	DT
cord-280549-bsnz24jx	622	26	viral	viral	JJ
cord-280549-bsnz24jx	622	27	protein	protein	NN
cord-280549-bsnz24jx	622	28	to	to	TO
cord-280549-bsnz24jx	622	29	chromatin	chromatin	VB
cord-280549-bsnz24jx	622	30	,	,	,
cord-280549-bsnz24jx	622	31	as	as	IN
cord-280549-bsnz24jx	622	32	mutants	mutant	NNS
cord-280549-bsnz24jx	622	33	which	which	WDT
cord-280549-bsnz24jx	622	34	are	be	VBP
cord-280549-bsnz24jx	622	35	unable	unable	JJ
cord-280549-bsnz24jx	622	36	to	to	TO
cord-280549-bsnz24jx	622	37	bind	bind	VB
cord-280549-bsnz24jx	622	38	chromatin	chromatin	NN
cord-280549-bsnz24jx	622	39	fail	fail	VB
cord-280549-bsnz24jx	622	40	to	to	TO
cord-280549-bsnz24jx	622	41	activate	activate	VB
cord-280549-bsnz24jx	622	42	ATR	ATR	NNP
cord-280549-bsnz24jx	622	43	(	(	-LRB-
cord-280549-bsnz24jx	622	44	Lai	Lai	NNP
cord-280549-bsnz24jx	622	45	et	et	FW
cord-280549-bsnz24jx	622	46	al	al	NNP
cord-280549-bsnz24jx	622	47	.	.	NNP
cord-280549-bsnz24jx	622	48	,	,	,
cord-280549-bsnz24jx	622	49	2005	2005	CD
cord-280549-bsnz24jx	622	50	)	)	-RRB-
cord-280549-bsnz24jx	622	51	,	,	,
cord-280549-bsnz24jx	622	52	although	although	IN
cord-280549-bsnz24jx	622	53	the	the	DT
cord-280549-bsnz24jx	622	54	underlying	underlying	JJ
cord-280549-bsnz24jx	622	55	mechanism	mechanism	NN
cord-280549-bsnz24jx	622	56	remains	remain	VBZ
cord-280549-bsnz24jx	622	57	controversial	controversial	JJ
cord-280549-bsnz24jx	622	58	.	.	.
cord-280549-bsnz24jx	623	1	Lai	Lai	NNP
cord-280549-bsnz24jx	623	2	et	et	NNP
cord-280549-bsnz24jx	623	3	al	al	NNP
cord-280549-bsnz24jx	623	4	.	.	NNP
cord-280549-bsnz24jx	623	5	reported	report	VBD
cord-280549-bsnz24jx	623	6	that	that	IN
cord-280549-bsnz24jx	623	7	Vpr	Vpr	NNP
cord-280549-bsnz24jx	623	8	does	do	VBZ
cord-280549-bsnz24jx	623	9	not	not	RB
cord-280549-bsnz24jx	623	10	induce	induce	VB
cord-280549-bsnz24jx	623	11	DNA	DNA	NNP
cord-280549-bsnz24jx	623	12	double	double	JJ
cord-280549-bsnz24jx	623	13	-	-	HYPH
cord-280549-bsnz24jx	623	14	strand	strand	NN
cord-280549-bsnz24jx	623	15	breaks	break	NNS
cord-280549-bsnz24jx	623	16	(	(	-LRB-
cord-280549-bsnz24jx	623	17	DSBs	DSBs	NNP
cord-280549-bsnz24jx	623	18	)	)	-RRB-
cord-280549-bsnz24jx	623	19	,	,	,
cord-280549-bsnz24jx	623	20	but	but	CC
cord-280549-bsnz24jx	623	21	increases	increase	VBZ
cord-280549-bsnz24jx	623	22	the	the	DT
cord-280549-bsnz24jx	623	23	association	association	NN
cord-280549-bsnz24jx	623	24	of	of	IN
cord-280549-bsnz24jx	623	25	replication	replication	NNP
cord-280549-bsnz24jx	623	26	protein	protein	NN
cord-280549-bsnz24jx	623	27	A	A	NNP
cord-280549-bsnz24jx	623	28	(	(	-LRB-
cord-280549-bsnz24jx	623	29	RPA	RPA	NNP
cord-280549-bsnz24jx	623	30	)	)	-RRB-
cord-280549-bsnz24jx	623	31	with	with	IN
cord-280549-bsnz24jx	623	32	chromatin	chromatin	NN
cord-280549-bsnz24jx	623	33	,	,	,
cord-280549-bsnz24jx	623	34	an	an	DT
cord-280549-bsnz24jx	623	35	upstream	upstream	JJ
cord-280549-bsnz24jx	623	36	event	event	NN
cord-280549-bsnz24jx	623	37	required	require	VBN
cord-280549-bsnz24jx	623	38	for	for	IN
cord-280549-bsnz24jx	623	39	ATR	ATR	NNP
cord-280549-bsnz24jx	623	40	activation	activation	NN
cord-280549-bsnz24jx	623	41	(	(	-LRB-
cord-280549-bsnz24jx	623	42	Cortez	Cortez	NNP
cord-280549-bsnz24jx	623	43	et	et	NNP
cord-280549-bsnz24jx	623	44	al	al	NNP
cord-280549-bsnz24jx	623	45	.	.	NNP
cord-280549-bsnz24jx	623	46	,	,	,
cord-280549-bsnz24jx	623	47	2001	2001	CD
cord-280549-bsnz24jx	623	48	;	;	:
cord-280549-bsnz24jx	623	49	Zou	Zou	NNP
cord-280549-bsnz24jx	623	50	and	and	CC
cord-280549-bsnz24jx	623	51	Elledge	Elledge	NNP
cord-280549-bsnz24jx	623	52	,	,	,
cord-280549-bsnz24jx	623	53	2003	2003	CD
cord-280549-bsnz24jx	623	54	;	;	:
cord-280549-bsnz24jx	623	55	Lai	Lai	NNP
cord-280549-bsnz24jx	623	56	et	et	NNP
cord-280549-bsnz24jx	623	57	al	al	NNP
cord-280549-bsnz24jx	623	58	.	.	NNP
cord-280549-bsnz24jx	623	59	,	,	,
cord-280549-bsnz24jx	623	60	2005	2005	CD
cord-280549-bsnz24jx	623	61	)	)	-RRB-
cord-280549-bsnz24jx	623	62	.	.	.
cord-280549-bsnz24jx	624	1	However	however	RB
cord-280549-bsnz24jx	624	2	,	,	,
cord-280549-bsnz24jx	624	3	using	use	VBG
cord-280549-bsnz24jx	624	4	the	the	DT
cord-280549-bsnz24jx	624	5	same	same	JJ
cord-280549-bsnz24jx	624	6	pulsed	pulse	VBN
cord-280549-bsnz24jx	624	7	-	-	HYPH
cord-280549-bsnz24jx	624	8	field	field	NN
cord-280549-bsnz24jx	624	9	gel	gel	NN
cord-280549-bsnz24jx	624	10	electrophoresis	electrophoresis	NN
cord-280549-bsnz24jx	624	11	assay	assay	NN
cord-280549-bsnz24jx	624	12	,	,	,
cord-280549-bsnz24jx	624	13	Tachiwana	Tachiwana	NNP
cord-280549-bsnz24jx	624	14	et	et	FW
cord-280549-bsnz24jx	624	15	al	al	NNP
cord-280549-bsnz24jx	624	16	.	.	.
cord-280549-bsnz24jx	625	1	later	later	RB
cord-280549-bsnz24jx	625	2	showed	show	VBD
cord-280549-bsnz24jx	625	3	that	that	IN
cord-280549-bsnz24jx	625	4	Vpr	Vpr	NNP
cord-280549-bsnz24jx	625	5	expression	expression	NN
cord-280549-bsnz24jx	625	6	could	could	MD
cord-280549-bsnz24jx	625	7	induce	induce	VB
cord-280549-bsnz24jx	625	8	chromosomal	chromosomal	JJ
cord-280549-bsnz24jx	625	9	DSBs	dsb	NNS
cord-280549-bsnz24jx	625	10	(	(	-LRB-
cord-280549-bsnz24jx	625	11	Tachiwana	Tachiwana	NNP
cord-280549-bsnz24jx	625	12	et	et	FW
cord-280549-bsnz24jx	625	13	al	al	NNP
cord-280549-bsnz24jx	625	14	.	.	NNP
cord-280549-bsnz24jx	625	15	,	,	,
cord-280549-bsnz24jx	625	16	2006	2006	CD
cord-280549-bsnz24jx	625	17	)	)	-RRB-
cord-280549-bsnz24jx	625	18	.	.	.
cord-280549-bsnz24jx	626	1	Differences	difference	NNS
cord-280549-bsnz24jx	626	2	in	in	IN
cord-280549-bsnz24jx	626	3	experimental	experimental	JJ
cord-280549-bsnz24jx	626	4	settings	setting	NNS
cord-280549-bsnz24jx	626	5	may	may	MD
cord-280549-bsnz24jx	626	6	underpin	underpin	VB
cord-280549-bsnz24jx	626	7	this	this	DT
cord-280549-bsnz24jx	626	8	discrepancy	discrepancy	NN
cord-280549-bsnz24jx	626	9	.	.	.
cord-280549-bsnz24jx	627	1	Lai	Lai	NNP
cord-280549-bsnz24jx	627	2	et	et	NNP
cord-280549-bsnz24jx	627	3	al	al	NNP
cord-280549-bsnz24jx	627	4	.	.	.
cord-280549-bsnz24jx	628	1	relied	rely	VBN
cord-280549-bsnz24jx	628	2	on	on	IN
cord-280549-bsnz24jx	628	3	Vpr	Vpr	NNP
cord-280549-bsnz24jx	628	4	-	-	HYPH
cord-280549-bsnz24jx	628	5	transfected	transfecte	VBN
cord-280549-bsnz24jx	628	6	cells	cell	NNS
cord-280549-bsnz24jx	628	7	for	for	IN
cord-280549-bsnz24jx	628	8	the	the	DT
cord-280549-bsnz24jx	628	9	PFGE	PFGE	NNP
cord-280549-bsnz24jx	628	10	analysis	analysis	NN
cord-280549-bsnz24jx	628	11	,	,	,
cord-280549-bsnz24jx	628	12	whereas	whereas	IN
cord-280549-bsnz24jx	628	13	isolated	isolate	VBN
cord-280549-bsnz24jx	628	14	nuclei	nucleus	NNS
cord-280549-bsnz24jx	628	15	that	that	WDT
cord-280549-bsnz24jx	628	16	were	be	VBD
cord-280549-bsnz24jx	628	17	treated	treat	VBN
cord-280549-bsnz24jx	628	18	with	with	IN
cord-280549-bsnz24jx	628	19	purified	purify	VBN
cord-280549-bsnz24jx	628	20	Vpr	Vpr	NNP
cord-280549-bsnz24jx	628	21	were	be	VBD
cord-280549-bsnz24jx	628	22	used	use	VBN
cord-280549-bsnz24jx	628	23	in	in	IN
cord-280549-bsnz24jx	628	24	the	the	DT
cord-280549-bsnz24jx	628	25	other	other	JJ
cord-280549-bsnz24jx	628	26	study	study	NN
cord-280549-bsnz24jx	628	27	.	.	.
cord-280549-bsnz24jx	629	1	The	the	DT
cord-280549-bsnz24jx	629	2	NS1	NS1	NNS
cord-280549-bsnz24jx	629	3	of	of	IN
cord-280549-bsnz24jx	629	4	the	the	DT
cord-280549-bsnz24jx	629	5	autonomous	autonomous	JJ
cord-280549-bsnz24jx	629	6	parvovirus	parvovirus	NN
cord-280549-bsnz24jx	629	7	minute	minute	NN
cord-280549-bsnz24jx	629	8	virus	virus	NN
cord-280549-bsnz24jx	629	9	of	of	IN
cord-280549-bsnz24jx	629	10	mice	mouse	NNS
cord-280549-bsnz24jx	629	11	(	(	-LRB-
cord-280549-bsnz24jx	629	12	MVMp	MVMp	NNS
cord-280549-bsnz24jx	629	13	)	)	-RRB-
cord-280549-bsnz24jx	629	14	is	be	VBZ
cord-280549-bsnz24jx	629	15	another	another	DT
cord-280549-bsnz24jx	629	16	example	example	NN
cord-280549-bsnz24jx	629	17	of	of	IN
cord-280549-bsnz24jx	629	18	viral	viral	JJ
cord-280549-bsnz24jx	629	19	protein	protein	NN
cord-280549-bsnz24jx	629	20	that	that	WDT
cord-280549-bsnz24jx	629	21	affects	affect	VBZ
cord-280549-bsnz24jx	629	22	the	the	DT
cord-280549-bsnz24jx	629	23	integrity	integrity	NN
cord-280549-bsnz24jx	629	24	of	of	IN
cord-280549-bsnz24jx	629	25	chromatin	chromatin	NN
cord-280549-bsnz24jx	629	26	.	.	.
cord-280549-bsnz24jx	630	1	MVMp	MVMp	NNS
cord-280549-bsnz24jx	630	2	infection	infection	NN
cord-280549-bsnz24jx	630	3	leads	lead	VBZ
cord-280549-bsnz24jx	630	4	to	to	IN
cord-280549-bsnz24jx	630	5	cell	cell	NN
cord-280549-bsnz24jx	630	6	cycle	cycle	NN
cord-280549-bsnz24jx	630	7	arrest	arrest	NN
cord-280549-bsnz24jx	630	8	in	in	IN
cord-280549-bsnz24jx	630	9	S	S	NNP
cord-280549-bsnz24jx	630	10	phase	phase	NN
cord-280549-bsnz24jx	630	11	as	as	IN
cord-280549-bsnz24jx	630	12	a	a	DT
cord-280549-bsnz24jx	630	13	result	result	NN
cord-280549-bsnz24jx	630	14	of	of	IN
cord-280549-bsnz24jx	630	15	NS1-induced	ns1-induced	JJ
cord-280549-bsnz24jx	630	16	nicks	nick	NNS
cord-280549-bsnz24jx	630	17	in	in	IN
cord-280549-bsnz24jx	630	18	the	the	DT
cord-280549-bsnz24jx	630	19	cellular	cellular	JJ
cord-280549-bsnz24jx	630	20	chromatin	chromatin	NN
cord-280549-bsnz24jx	630	21	(	(	-LRB-
cord-280549-bsnz24jx	630	22	Op	Op	NNP
cord-280549-bsnz24jx	630	23	De	De	NNP
cord-280549-bsnz24jx	630	24	Beeck	Beeck	NNP
cord-280549-bsnz24jx	630	25	et	et	FW
cord-280549-bsnz24jx	630	26	al	al	NNP
cord-280549-bsnz24jx	630	27	.	.	NNP
cord-280549-bsnz24jx	630	28	,	,	,
cord-280549-bsnz24jx	630	29	1995	1995	CD
cord-280549-bsnz24jx	630	30	;	;	:
cord-280549-bsnz24jx	631	1	Op	Op	NNP
cord-280549-bsnz24jx	631	2	De	De	NNP
cord-280549-bsnz24jx	631	3	Beeck	Beeck	NNP
cord-280549-bsnz24jx	631	4	and	and	CC
cord-280549-bsnz24jx	631	5	Caillet	Caillet	NNP
cord-280549-bsnz24jx	631	6	-	-	HYPH
cord-280549-bsnz24jx	631	7	Fauquet	Fauquet	NNP
cord-280549-bsnz24jx	631	8	,	,	,
cord-280549-bsnz24jx	631	9	1997	1997	CD
cord-280549-bsnz24jx	631	10	)	)	-RRB-
cord-280549-bsnz24jx	631	11	.	.	.
cord-280549-bsnz24jx	632	1	Infection	infection	NN
cord-280549-bsnz24jx	632	2	of	of	IN
cord-280549-bsnz24jx	632	3	adeno	adeno	NN
cord-280549-bsnz24jx	632	4	-	-	HYPH
cord-280549-bsnz24jx	632	5	associated	associate	VBN
cord-280549-bsnz24jx	632	6	virus	virus	NN
cord-280549-bsnz24jx	632	7	(	(	-LRB-
cord-280549-bsnz24jx	632	8	AAV	AAV	NNP
cord-280549-bsnz24jx	632	9	)	)	-RRB-
cord-280549-bsnz24jx	632	10	leads	lead	VBZ
cord-280549-bsnz24jx	632	11	to	to	IN
cord-280549-bsnz24jx	632	12	accumulation	accumulation	NN
cord-280549-bsnz24jx	632	13	of	of	IN
cord-280549-bsnz24jx	632	14	cells	cell	NNS
cord-280549-bsnz24jx	632	15	with	with	IN
cord-280549-bsnz24jx	632	16	4N	4n	CD
cord-280549-bsnz24jx	632	17	DNA	dna	NN
cord-280549-bsnz24jx	632	18	content	content	NN
cord-280549-bsnz24jx	632	19	in	in	IN
cord-280549-bsnz24jx	632	20	p53-competent	p53-competent	NN
cord-280549-bsnz24jx	632	21	cells	cell	NNS
cord-280549-bsnz24jx	632	22	,	,	,
cord-280549-bsnz24jx	632	23	whereas	whereas	IN
cord-280549-bsnz24jx	632	24	it	-PRON-	PRP
cord-280549-bsnz24jx	632	25	induces	induce	VBZ
cord-280549-bsnz24jx	632	26	apoptosis	apoptosis	NN
cord-280549-bsnz24jx	632	27	in	in	IN
cord-280549-bsnz24jx	632	28	p53-deficient	p53-deficient	NN
cord-280549-bsnz24jx	632	29	cells	cell	NNS
cord-280549-bsnz24jx	632	30	(	(	-LRB-
cord-280549-bsnz24jx	632	31	Raj	Raj	NNP
cord-280549-bsnz24jx	632	32	et	et	NNP
cord-280549-bsnz24jx	632	33	al	al	NNP
cord-280549-bsnz24jx	632	34	.	.	NNP
cord-280549-bsnz24jx	632	35	,	,	,
cord-280549-bsnz24jx	632	36	2001	2001	CD
cord-280549-bsnz24jx	632	37	)	)	-RRB-
cord-280549-bsnz24jx	632	38	.	.	.
cord-280549-bsnz24jx	633	1	Interestingly	interestingly	RB
cord-280549-bsnz24jx	633	2	,	,	,
cord-280549-bsnz24jx	633	3	virus	virus	NN
cord-280549-bsnz24jx	633	4	replication	replication	NN
cord-280549-bsnz24jx	633	5	or	or	CC
cord-280549-bsnz24jx	633	6	viral	viral	JJ
cord-280549-bsnz24jx	633	7	protein	protein	NN
cord-280549-bsnz24jx	633	8	expression	expression	NN
cord-280549-bsnz24jx	633	9	is	be	VBZ
cord-280549-bsnz24jx	633	10	not	not	RB
cord-280549-bsnz24jx	633	11	required	require	VBN
cord-280549-bsnz24jx	633	12	for	for	IN
cord-280549-bsnz24jx	633	13	AAV	AAV	NNP
cord-280549-bsnz24jx	633	14	-	-	HYPH
cord-280549-bsnz24jx	633	15	mediated	mediate	VBN
cord-280549-bsnz24jx	633	16	cell	cell	NN
cord-280549-bsnz24jx	633	17	cycle	cycle	NN
cord-280549-bsnz24jx	633	18	arrest	arrest	NN
cord-280549-bsnz24jx	633	19	as	as	IN
cord-280549-bsnz24jx	633	20	ultraviolet	ultraviolet	NN
cord-280549-bsnz24jx	633	21	-	-	HYPH
cord-280549-bsnz24jx	633	22	treated	treat	VBN
cord-280549-bsnz24jx	633	23	AAV	AAV	NNP
cord-280549-bsnz24jx	633	24	maintain	maintain	VBP
cord-280549-bsnz24jx	633	25	their	-PRON-	PRP$
cord-280549-bsnz24jx	633	26	ability	ability	NN
cord-280549-bsnz24jx	633	27	to	to	TO
cord-280549-bsnz24jx	633	28	perturb	perturb	VB
cord-280549-bsnz24jx	633	29	cell	cell	NN
cord-280549-bsnz24jx	633	30	cycle	cycle	NN
cord-280549-bsnz24jx	633	31	,	,	,
cord-280549-bsnz24jx	633	32	pointing	point	VBG
cord-280549-bsnz24jx	633	33	to	to	IN
cord-280549-bsnz24jx	633	34	the	the	DT
cord-280549-bsnz24jx	633	35	role	role	NN
cord-280549-bsnz24jx	633	36	of	of	IN
cord-280549-bsnz24jx	633	37	AAV	AAV	NNP
cord-280549-bsnz24jx	633	38	genome	genome	NN
cord-280549-bsnz24jx	633	39	in	in	IN
cord-280549-bsnz24jx	633	40	these	these	DT
cord-280549-bsnz24jx	633	41	effects	effect	NNS
cord-280549-bsnz24jx	633	42	(	(	-LRB-
cord-280549-bsnz24jx	633	43	Raj	Raj	NNP
cord-280549-bsnz24jx	633	44	et	et	NNP
cord-280549-bsnz24jx	633	45	al	al	NNP
cord-280549-bsnz24jx	633	46	.	.	NNP
cord-280549-bsnz24jx	633	47	,	,	,
cord-280549-bsnz24jx	633	48	2001	2001	CD
cord-280549-bsnz24jx	633	49	)	)	-RRB-
cord-280549-bsnz24jx	633	50	.	.	.
cord-280549-bsnz24jx	634	1	In	in	IN
cord-280549-bsnz24jx	634	2	support	support	NN
cord-280549-bsnz24jx	634	3	of	of	IN
cord-280549-bsnz24jx	634	4	this	this	DT
cord-280549-bsnz24jx	634	5	hypothesis	hypothesis	NN
cord-280549-bsnz24jx	634	6	,	,	,
cord-280549-bsnz24jx	634	7	empty	empty	JJ
cord-280549-bsnz24jx	634	8	AAV	AAV	NNP
cord-280549-bsnz24jx	634	9	particles	particle	NNS
cord-280549-bsnz24jx	634	10	,	,	,
cord-280549-bsnz24jx	634	11	which	which	WDT
cord-280549-bsnz24jx	634	12	lack	lack	VBP
cord-280549-bsnz24jx	634	13	viral	viral	JJ
cord-280549-bsnz24jx	634	14	genome	genome	NN
cord-280549-bsnz24jx	634	15	,	,	,
cord-280549-bsnz24jx	634	16	fail	fail	VBP
cord-280549-bsnz24jx	634	17	to	to	TO
cord-280549-bsnz24jx	634	18	affect	affect	VB
cord-280549-bsnz24jx	634	19	cell	cell	NN
cord-280549-bsnz24jx	634	20	growth	growth	NN
cord-280549-bsnz24jx	634	21	(	(	-LRB-
cord-280549-bsnz24jx	634	22	Raj	Raj	NNP
cord-280549-bsnz24jx	634	23	et	et	NNP
cord-280549-bsnz24jx	634	24	al	al	NNP
cord-280549-bsnz24jx	634	25	.	.	NNP
cord-280549-bsnz24jx	634	26	,	,	,
cord-280549-bsnz24jx	634	27	2001	2001	CD
cord-280549-bsnz24jx	634	28	)	)	-RRB-
cord-280549-bsnz24jx	634	29	.	.	.
cord-280549-bsnz24jx	635	1	It	-PRON-	PRP
cord-280549-bsnz24jx	635	2	was	be	VBD
cord-280549-bsnz24jx	635	3	proposed	propose	VBN
cord-280549-bsnz24jx	635	4	that	that	IN
cord-280549-bsnz24jx	635	5	the	the	DT
cord-280549-bsnz24jx	635	6	special	special	JJ
cord-280549-bsnz24jx	635	7	structure	structure	NN
cord-280549-bsnz24jx	635	8	of	of	IN
cord-280549-bsnz24jx	635	9	AAV	AAV	NNP
cord-280549-bsnz24jx	635	10	genome	genome	NN
cord-280549-bsnz24jx	635	11	,	,	,
cord-280549-bsnz24jx	635	12	a	a	DT
cord-280549-bsnz24jx	635	13	single	single	RB
cord-280549-bsnz24jx	635	14	-	-	HYPH
cord-280549-bsnz24jx	635	15	stranded	strand	VBN
cord-280549-bsnz24jx	635	16	DNA	dna	NN
cord-280549-bsnz24jx	635	17	with	with	IN
cord-280549-bsnz24jx	635	18	hairpin	hairpin	JJ
cord-280549-bsnz24jx	635	19	loops	loop	NNS
cord-280549-bsnz24jx	635	20	at	at	IN
cord-280549-bsnz24jx	635	21	both	both	DT
cord-280549-bsnz24jx	635	22	ends	end	NNS
cord-280549-bsnz24jx	635	23	,	,	,
cord-280549-bsnz24jx	635	24	could	could	MD
cord-280549-bsnz24jx	635	25	trigger	trigger	VB
cord-280549-bsnz24jx	635	26	host	host	NN
cord-280549-bsnz24jx	635	27	DNA	dna	NN
cord-280549-bsnz24jx	635	28	damage	damage	NN
cord-280549-bsnz24jx	635	29	response	response	NN
cord-280549-bsnz24jx	635	30	and	and	CC
cord-280549-bsnz24jx	635	31	mediate	mediate	VB
cord-280549-bsnz24jx	635	32	cell	cell	NN
cord-280549-bsnz24jx	635	33	cycle	cycle	NN
cord-280549-bsnz24jx	635	34	arrest	arrest	NN
cord-280549-bsnz24jx	635	35	in	in	IN
cord-280549-bsnz24jx	635	36	a	a	DT
cord-280549-bsnz24jx	635	37	p53	p53	NN
cord-280549-bsnz24jx	635	38	/	/	SYM
cord-280549-bsnz24jx	635	39	p21	p21	NN
cord-280549-bsnz24jx	635	40	WAF1	WAF1	NNP
cord-280549-bsnz24jx	635	41	/	/	SYM
cord-280549-bsnz24jx	635	42	CIP1	CIP1	NNP
cord-280549-bsnz24jx	635	43	-dependent	-dependent	JJ
cord-280549-bsnz24jx	635	44	manner	manner	NN
cord-280549-bsnz24jx	636	1	(	(	-LRB-
cord-280549-bsnz24jx	636	2	Raj	Raj	NNP
cord-280549-bsnz24jx	636	3	et	et	NNP
cord-280549-bsnz24jx	636	4	al	al	NNP
cord-280549-bsnz24jx	636	5	.	.	NNP
cord-280549-bsnz24jx	636	6	,	,	,
cord-280549-bsnz24jx	636	7	2001	2001	CD
cord-280549-bsnz24jx	636	8	)	)	-RRB-
cord-280549-bsnz24jx	636	9	.	.	.
cord-280549-bsnz24jx	637	1	Indeed	indeed	RB
cord-280549-bsnz24jx	637	2	,	,	,
cord-280549-bsnz24jx	637	3	using	use	VBG
cord-280549-bsnz24jx	637	4	an	an	DT
cord-280549-bsnz24jx	637	5	oligonucleotide	oligonucleotide	NN
cord-280549-bsnz24jx	637	6	corresponding	correspond	VBG
cord-280549-bsnz24jx	637	7	to	to	IN
cord-280549-bsnz24jx	637	8	the	the	DT
cord-280549-bsnz24jx	637	9	AAV	AAV	NNP
cord-280549-bsnz24jx	637	10	hairpin	hairpin	NN
cord-280549-bsnz24jx	637	11	structure	structure	NN
cord-280549-bsnz24jx	637	12	but	but	CC
cord-280549-bsnz24jx	637	13	not	not	RB
cord-280549-bsnz24jx	637	14	the	the	DT
cord-280549-bsnz24jx	637	15	AAV	AAV	NNP
cord-280549-bsnz24jx	637	16	coding	coding	NN
cord-280549-bsnz24jx	637	17	sequence	sequence	NN
cord-280549-bsnz24jx	637	18	,	,	,
cord-280549-bsnz24jx	637	19	the	the	DT
cord-280549-bsnz24jx	637	20	same	same	JJ
cord-280549-bsnz24jx	637	21	group	group	NN
cord-280549-bsnz24jx	637	22	successfully	successfully	RB
cord-280549-bsnz24jx	637	23	replicated	replicate	VBD
cord-280549-bsnz24jx	637	24	the	the	DT
cord-280549-bsnz24jx	637	25	phenotypes	phenotype	NNS
cord-280549-bsnz24jx	637	26	induced	induce	VBN
cord-280549-bsnz24jx	637	27	by	by	IN
cord-280549-bsnz24jx	637	28	AAV	AAV	NNP
cord-280549-bsnz24jx	637	29	infection	infection	NN
cord-280549-bsnz24jx	637	30	(	(	-LRB-
cord-280549-bsnz24jx	637	31	Raj	Raj	NNP
cord-280549-bsnz24jx	637	32	et	et	NNP
cord-280549-bsnz24jx	637	33	al	al	NNP
cord-280549-bsnz24jx	637	34	.	.	NNP
cord-280549-bsnz24jx	637	35	,	,	,
cord-280549-bsnz24jx	637	36	2001	2001	CD
cord-280549-bsnz24jx	637	37	)	)	-RRB-
cord-280549-bsnz24jx	637	38	.	.	.
cord-280549-bsnz24jx	638	1	Likewise	likewise	RB
cord-280549-bsnz24jx	638	2	,	,	,
cord-280549-bsnz24jx	638	3	expression	expression	NN
cord-280549-bsnz24jx	638	4	of	of	IN
cord-280549-bsnz24jx	638	5	the	the	DT
cord-280549-bsnz24jx	638	6	individual	individual	JJ
cord-280549-bsnz24jx	638	7	proteins	protein	NNS
cord-280549-bsnz24jx	638	8	of	of	IN
cord-280549-bsnz24jx	638	9	Bocavirus	Bocavirus	NNP
cord-280549-bsnz24jx	638	10	minute	minute	NN
cord-280549-bsnz24jx	638	11	virus	virus	NN
cord-280549-bsnz24jx	638	12	of	of	IN
cord-280549-bsnz24jx	638	13	canines	canine	NNS
cord-280549-bsnz24jx	638	14	(	(	-LRB-
cord-280549-bsnz24jx	638	15	MVC	MVC	NNP
cord-280549-bsnz24jx	638	16	)	)	-RRB-
cord-280549-bsnz24jx	638	17	has	have	VBZ
cord-280549-bsnz24jx	638	18	no	no	DT
cord-280549-bsnz24jx	638	19	effect	effect	NN
cord-280549-bsnz24jx	638	20	on	on	IN
cord-280549-bsnz24jx	638	21	cell	cell	NN
cord-280549-bsnz24jx	638	22	cycle	cycle	NN
cord-280549-bsnz24jx	638	23	progression	progression	NN
cord-280549-bsnz24jx	638	24	(	(	-LRB-
cord-280549-bsnz24jx	638	25	Chen	Chen	NNP
cord-280549-bsnz24jx	638	26	et	et	NNP
cord-280549-bsnz24jx	638	27	al	al	NNP
cord-280549-bsnz24jx	638	28	.	.	NNP
cord-280549-bsnz24jx	638	29	,	,	,
cord-280549-bsnz24jx	638	30	2010	2010	CD
cord-280549-bsnz24jx	638	31	)	)	-RRB-
cord-280549-bsnz24jx	638	32	.	.	.
cord-280549-bsnz24jx	639	1	However	however	RB
cord-280549-bsnz24jx	639	2	,	,	,
cord-280549-bsnz24jx	639	3	(	(	-LRB-
cord-280549-bsnz24jx	639	4	Chen	Chen	NNP
cord-280549-bsnz24jx	639	5	et	et	NNP
cord-280549-bsnz24jx	639	6	al	al	NNP
cord-280549-bsnz24jx	639	7	.	.	NNP
cord-280549-bsnz24jx	639	8	,	,	,
cord-280549-bsnz24jx	639	9	2010	2010	CD
cord-280549-bsnz24jx	639	10	)	)	-RRB-
cord-280549-bsnz24jx	639	11	.	.	.
cord-280549-bsnz24jx	640	1	Indeed	indeed	RB
cord-280549-bsnz24jx	640	2	,	,	,
cord-280549-bsnz24jx	640	3	the	the	DT
cord-280549-bsnz24jx	640	4	use	use	NN
cord-280549-bsnz24jx	640	5	of	of	IN
cord-280549-bsnz24jx	640	6	a	a	DT
cord-280549-bsnz24jx	640	7	series	series	NN
cord-280549-bsnz24jx	640	8	of	of	IN
cord-280549-bsnz24jx	640	9	MVC	MVC	NNP
cord-280549-bsnz24jx	640	10	mutant	mutant	JJ
cord-280549-bsnz24jx	640	11	constructs	construct	NNS
cord-280549-bsnz24jx	640	12	indicated	indicate	VBD
cord-280549-bsnz24jx	640	13	the	the	DT
cord-280549-bsnz24jx	640	14	terminal	terminal	NN
cord-280549-bsnz24jx	640	15	repeats	repeat	NNS
cord-280549-bsnz24jx	640	16	of	of	IN
cord-280549-bsnz24jx	640	17	its	-PRON-	PRP$
cord-280549-bsnz24jx	640	18	genome	genome	NN
cord-280549-bsnz24jx	640	19	,	,	,
cord-280549-bsnz24jx	640	20	which	which	WDT
cord-280549-bsnz24jx	640	21	form	form	VBP
cord-280549-bsnz24jx	640	22	a	a	DT
cord-280549-bsnz24jx	640	23	strong	strong	JJ
cord-280549-bsnz24jx	640	24	secondary	secondary	JJ
cord-280549-bsnz24jx	640	25	structure	structure	NN
cord-280549-bsnz24jx	640	26	,	,	,
cord-280549-bsnz24jx	640	27	are	be	VBP
cord-280549-bsnz24jx	640	28	essential	essential	JJ
cord-280549-bsnz24jx	640	29	in	in	IN
cord-280549-bsnz24jx	640	30	the	the	DT
cord-280549-bsnz24jx	640	31	G2	G2	NNP
cord-280549-bsnz24jx	640	32	/	/	SYM
cord-280549-bsnz24jx	640	33	M	M	NNP
cord-280549-bsnz24jx	640	34	arrest	arrest	NN
cord-280549-bsnz24jx	640	35	feature	feature	NN
cord-280549-bsnz24jx	640	36	of	of	IN
cord-280549-bsnz24jx	640	37	MVC	MVC	NNP
cord-280549-bsnz24jx	640	38	(	(	-LRB-
cord-280549-bsnz24jx	640	39	Sun	Sun	NNP
cord-280549-bsnz24jx	640	40	et	et	FW
cord-280549-bsnz24jx	640	41	al	al	NNP
cord-280549-bsnz24jx	640	42	.	.	NNP
cord-280549-bsnz24jx	640	43	,	,	,
cord-280549-bsnz24jx	640	44	2009	2009	CD
cord-280549-bsnz24jx	640	45	;	;	:
cord-280549-bsnz24jx	640	46	Chen	Chen	NNP
cord-280549-bsnz24jx	640	47	et	et	NNP
cord-280549-bsnz24jx	640	48	al	al	NNP
cord-280549-bsnz24jx	640	49	.	.	NNP
cord-280549-bsnz24jx	640	50	,	,	,
cord-280549-bsnz24jx	640	51	2010	2010	CD
cord-280549-bsnz24jx	640	52	)	)	-RRB-
cord-280549-bsnz24jx	640	53	.	.	.
cord-280549-bsnz24jx	641	1	Other	other	JJ
cord-280549-bsnz24jx	641	2	than	than	IN
cord-280549-bsnz24jx	641	3	viral	viral	JJ
cord-280549-bsnz24jx	641	4	proteins	protein	NNS
cord-280549-bsnz24jx	641	5	and	and	CC
cord-280549-bsnz24jx	641	6	genome	genome	NN
cord-280549-bsnz24jx	641	7	,	,	,
cord-280549-bsnz24jx	641	8	virus	virus	NN
cord-280549-bsnz24jx	641	9	-	-	HYPH
cord-280549-bsnz24jx	641	10	encoded	encode	VBN
cord-280549-bsnz24jx	641	11	microRNAs	microrna	NNS
cord-280549-bsnz24jx	641	12	(	(	-LRB-
cord-280549-bsnz24jx	641	13	miRNAs	miRNAs	NNP
cord-280549-bsnz24jx	641	14	)	)	-RRB-
cord-280549-bsnz24jx	641	15	have	have	VBP
cord-280549-bsnz24jx	641	16	been	be	VBN
cord-280549-bsnz24jx	641	17	also	also	RB
cord-280549-bsnz24jx	641	18	implicated	implicate	VBN
cord-280549-bsnz24jx	641	19	to	to	TO
cord-280549-bsnz24jx	641	20	play	play	VB
cord-280549-bsnz24jx	641	21	a	a	DT
cord-280549-bsnz24jx	641	22	role	role	NN
cord-280549-bsnz24jx	641	23	in	in	IN
cord-280549-bsnz24jx	641	24	regulating	regulate	VBG
cord-280549-bsnz24jx	641	25	host	host	NN
cord-280549-bsnz24jx	641	26	cell	cell	NN
cord-280549-bsnz24jx	641	27	cycle	cycle	NN
cord-280549-bsnz24jx	641	28	.	.	.
cord-280549-bsnz24jx	642	1	For	for	IN
cord-280549-bsnz24jx	642	2	example	example	NN
cord-280549-bsnz24jx	642	3	,	,	,
cord-280549-bsnz24jx	642	4	KSHV	KSHV	NNP
cord-280549-bsnz24jx	642	5	miRNA	miRNA	NNP
cord-280549-bsnz24jx	642	6	K1	K1	NNP
cord-280549-bsnz24jx	642	7	specifically	specifically	RB
cord-280549-bsnz24jx	642	8	represses	repress	VBZ
cord-280549-bsnz24jx	642	9	the	the	DT
cord-280549-bsnz24jx	642	10	expression	expression	NN
cord-280549-bsnz24jx	642	11	of	of	IN
cord-280549-bsnz24jx	642	12	p21	p21	NN
cord-280549-bsnz24jx	642	13	WAF1	WAF1	NNP
cord-280549-bsnz24jx	642	14	/	/	SYM
cord-280549-bsnz24jx	642	15	CIP1	CIP1	NNP
cord-280549-bsnz24jx	642	16	via	via	IN
cord-280549-bsnz24jx	642	17	the	the	DT
cord-280549-bsnz24jx	642	18	3	3	CD
cord-280549-bsnz24jx	642	19	′	′	CD
cord-280549-bsnz24jx	642	20	-UTR	-utr	NN
cord-280549-bsnz24jx	642	21	of	of	IN
cord-280549-bsnz24jx	642	22	this	this	DT
cord-280549-bsnz24jx	642	23	CKI	CKI	NNP
cord-280549-bsnz24jx	642	24	,	,	,
cord-280549-bsnz24jx	642	25	antagonizing	antagonize	VBG
cord-280549-bsnz24jx	642	26	p21	p21	NN
cord-280549-bsnz24jx	642	27	WAF1	WAF1	NNP
cord-280549-bsnz24jx	642	28	/	/	SYM
cord-280549-bsnz24jx	642	29	CIP1	CIP1	NNP
cord-280549-bsnz24jx	642	30	-mediated	-mediated	JJ
cord-280549-bsnz24jx	642	31	cell	cell	NN
cord-280549-bsnz24jx	642	32	cycle	cycle	NN
cord-280549-bsnz24jx	642	33	arrest	arrest	NN
cord-280549-bsnz24jx	642	34	(	(	-LRB-
cord-280549-bsnz24jx	642	35	Gottwein	Gottwein	NNP
cord-280549-bsnz24jx	642	36	and	and	CC
cord-280549-bsnz24jx	642	37	Cullen	Cullen	NNP
cord-280549-bsnz24jx	642	38	,	,	,
cord-280549-bsnz24jx	642	39	2010	2010	CD
cord-280549-bsnz24jx	642	40	)	)	-RRB-
cord-280549-bsnz24jx	642	41	.	.	.
cord-280549-bsnz24jx	643	1	The	the	DT
cord-280549-bsnz24jx	643	2	significance	significance	NN
cord-280549-bsnz24jx	643	3	of	of	IN
cord-280549-bsnz24jx	643	4	viral	viral	JJ
cord-280549-bsnz24jx	643	5	miRNA	miRNA	NNP
cord-280549-bsnz24jx	643	6	in	in	IN
cord-280549-bsnz24jx	643	7	favoring	favor	VBG
cord-280549-bsnz24jx	643	8	cell	cell	NN
cord-280549-bsnz24jx	643	9	cycle	cycle	NN
cord-280549-bsnz24jx	643	10	progression	progression	NN
cord-280549-bsnz24jx	643	11	was	be	VBD
cord-280549-bsnz24jx	643	12	studied	study	VBN
cord-280549-bsnz24jx	643	13	by	by	IN
cord-280549-bsnz24jx	643	14	introducing	introduce	VBG
cord-280549-bsnz24jx	643	15	mutations	mutation	NNS
cord-280549-bsnz24jx	643	16	into	into	IN
cord-280549-bsnz24jx	643	17	the	the	DT
cord-280549-bsnz24jx	643	18	precursor	precursor	NN
cord-280549-bsnz24jx	643	19	miRNA	miRNA	NNP
cord-280549-bsnz24jx	643	20	transcripts	transcript	NNS
cord-280549-bsnz24jx	643	21	of	of	IN
cord-280549-bsnz24jx	643	22	EBV	EBV	NNP
cord-280549-bsnz24jx	643	23	,	,	,
cord-280549-bsnz24jx	643	24	which	which	WDT
cord-280549-bsnz24jx	643	25	prevents	prevent	VBZ
cord-280549-bsnz24jx	643	26	the	the	DT
cord-280549-bsnz24jx	643	27	subsequent	subsequent	JJ
cord-280549-bsnz24jx	643	28	production	production	NN
cord-280549-bsnz24jx	643	29	of	of	IN
cord-280549-bsnz24jx	643	30	mature	mature	JJ
cord-280549-bsnz24jx	643	31	viral	viral	JJ
cord-280549-bsnz24jx	643	32	miRNAs	miRNAs	NNP
cord-280549-bsnz24jx	643	33	thus	thus	RB
cord-280549-bsnz24jx	643	34	antagonizes	antagonize	VBZ
cord-280549-bsnz24jx	643	35	both	both	DT
cord-280549-bsnz24jx	643	36	early	early	JJ
cord-280549-bsnz24jx	643	37	B	b	NN
cord-280549-bsnz24jx	643	38	-	-	HYPH
cord-280549-bsnz24jx	643	39	cell	cell	NN
cord-280549-bsnz24jx	643	40	proliferation	proliferation	NN
cord-280549-bsnz24jx	643	41	and	and	CC
cord-280549-bsnz24jx	643	42	miRNA	miRNA	NNP
cord-280549-bsnz24jx	643	43	protection	protection	NN
cord-280549-bsnz24jx	643	44	from	from	IN
cord-280549-bsnz24jx	643	45	spontaneous	spontaneous	JJ
cord-280549-bsnz24jx	643	46	apoptosis	apoptosis	NN
cord-280549-bsnz24jx	643	47	(	(	-LRB-
cord-280549-bsnz24jx	643	48	Seto	Seto	NNP
cord-280549-bsnz24jx	643	49	et	et	FW
cord-280549-bsnz24jx	643	50	al	al	NNP
cord-280549-bsnz24jx	643	51	.	.	NNP
cord-280549-bsnz24jx	643	52	,	,	,
cord-280549-bsnz24jx	643	53	2010	2010	CD
cord-280549-bsnz24jx	643	54	)	)	-RRB-
cord-280549-bsnz24jx	643	55	.	.	.
cord-280549-bsnz24jx	644	1	Measles	measles	NN
cord-280549-bsnz24jx	644	2	virus	virus	NN
cord-280549-bsnz24jx	644	3	(	(	-LRB-
cord-280549-bsnz24jx	644	4	MV	MV	NNP
cord-280549-bsnz24jx	644	5	)	)	-RRB-
cord-280549-bsnz24jx	644	6	was	be	VBD
cord-280549-bsnz24jx	644	7	reported	report	VBN
cord-280549-bsnz24jx	644	8	to	to	TO
cord-280549-bsnz24jx	644	9	subvert	subvert	VB
cord-280549-bsnz24jx	644	10	dendritic	dendritic	JJ
cord-280549-bsnz24jx	644	11	cells	cell	NNS
cord-280549-bsnz24jx	644	12	(	(	-LRB-
cord-280549-bsnz24jx	644	13	DCs	DCs	NNP
cord-280549-bsnz24jx	644	14	)	)	-RRB-
cord-280549-bsnz24jx	644	15	and	and	CC
cord-280549-bsnz24jx	644	16	induce	induce	VB
cord-280549-bsnz24jx	644	17	immune	immune	JJ
cord-280549-bsnz24jx	644	18	suppression	suppression	NN
cord-280549-bsnz24jx	644	19	.	.	.
cord-280549-bsnz24jx	645	1	Dubois	Dubois	NNP
cord-280549-bsnz24jx	645	2	et	et	NNP
cord-280549-bsnz24jx	645	3	al	al	NNP
cord-280549-bsnz24jx	645	4	.	.	.
cord-280549-bsnz24jx	646	1	found	find	VBD
cord-280549-bsnz24jx	646	2	that	that	IN
cord-280549-bsnz24jx	646	3	infection	infection	NN
cord-280549-bsnz24jx	646	4	of	of	IN
cord-280549-bsnz24jx	646	5	DCs	dc	NNS
cord-280549-bsnz24jx	646	6	by	by	IN
cord-280549-bsnz24jx	646	7	MV	MV	NNP
cord-280549-bsnz24jx	646	8	led	lead	VBD
cord-280549-bsnz24jx	646	9	to	to	IN
cord-280549-bsnz24jx	646	10	their	-PRON-	PRP$
cord-280549-bsnz24jx	646	11	functional	functional	JJ
cord-280549-bsnz24jx	646	12	maturation	maturation	NN
cord-280549-bsnz24jx	646	13	,	,	,
cord-280549-bsnz24jx	646	14	allowing	allow	VBG
cord-280549-bsnz24jx	646	15	the	the	DT
cord-280549-bsnz24jx	646	16	migration	migration	NN
cord-280549-bsnz24jx	646	17	of	of	IN
cord-280549-bsnz24jx	646	18	DCs	dc	NNS
cord-280549-bsnz24jx	646	19	from	from	IN
cord-280549-bsnz24jx	646	20	mucosal	mucosal	JJ
cord-280549-bsnz24jx	646	21	surfaces	surface	NNS
cord-280549-bsnz24jx	646	22	to	to	IN
cord-280549-bsnz24jx	646	23	draining	drain	VBG
cord-280549-bsnz24jx	646	24	lymph	lymph	NN
cord-280549-bsnz24jx	646	25	nodes	node	NNS
cord-280549-bsnz24jx	646	26	to	to	IN
cord-280549-bsnz24jx	646	27	prime	prime	JJ
cord-280549-bsnz24jx	646	28	naive	naive	JJ
cord-280549-bsnz24jx	646	29	T	t	NN
cord-280549-bsnz24jx	646	30	cells	cell	NNS
cord-280549-bsnz24jx	646	31	(	(	-LRB-
cord-280549-bsnz24jx	646	32	Dubois	Dubois	NNP
cord-280549-bsnz24jx	646	33	et	et	NNP
cord-280549-bsnz24jx	646	34	al	al	NNP
cord-280549-bsnz24jx	646	35	.	.	NNP
cord-280549-bsnz24jx	646	36	,	,	,
cord-280549-bsnz24jx	646	37	2001	2001	CD
cord-280549-bsnz24jx	646	38	)	)	-RRB-
cord-280549-bsnz24jx	646	39	.	.	.
cord-280549-bsnz24jx	647	1	Interestingly	interestingly	RB
cord-280549-bsnz24jx	647	2	,	,	,
cord-280549-bsnz24jx	647	3	instead	instead	RB
cord-280549-bsnz24jx	647	4	of	of	IN
cord-280549-bsnz24jx	647	5	activating	activate	VBG
cord-280549-bsnz24jx	647	6	T	t	NN
cord-280549-bsnz24jx	647	7	cells	cell	NNS
cord-280549-bsnz24jx	647	8	,	,	,
cord-280549-bsnz24jx	647	9	MV	MV	NNP
cord-280549-bsnz24jx	647	10	-	-	HYPH
cord-280549-bsnz24jx	647	11	infected	infect	VBN
cord-280549-bsnz24jx	647	12	DCs	DCs	NNP
cord-280549-bsnz24jx	647	13	block	block	NN
cord-280549-bsnz24jx	647	14	T	T	NNP
cord-280549-bsnz24jx	647	15	-	-	HYPH
cord-280549-bsnz24jx	647	16	cell	cell	NN
cord-280549-bsnz24jx	647	17	expansion	expansion	NN
cord-280549-bsnz24jx	647	18	through	through	IN
cord-280549-bsnz24jx	647	19	cell	cell	NN
cord-280549-bsnz24jx	647	20	-	-	HYPH
cord-280549-bsnz24jx	647	21	to	to	IN
cord-280549-bsnz24jx	647	22	-	-	HYPH
cord-280549-bsnz24jx	647	23	cell	cell	NN
cord-280549-bsnz24jx	647	24	contact	contact	NN
cord-280549-bsnz24jx	647	25	.	.	.
cord-280549-bsnz24jx	648	1	The	the	DT
cord-280549-bsnz24jx	648	2	use	use	NN
cord-280549-bsnz24jx	648	3	of	of	IN
cord-280549-bsnz24jx	648	4	anti	anti	JJ
cord-280549-bsnz24jx	648	5	-	-	JJ
cord-280549-bsnz24jx	648	6	MV	MV	NNP
cord-280549-bsnz24jx	648	7	HA	HA	NNP
cord-280549-bsnz24jx	648	8	or	or	CC
cord-280549-bsnz24jx	648	9	fusion	fusion	NN
cord-280549-bsnz24jx	648	10	protein	protein	NN
cord-280549-bsnz24jx	648	11	(	(	-LRB-
cord-280549-bsnz24jx	648	12	F	F	NNP
cord-280549-bsnz24jx	648	13	)	)	-RRB-
cord-280549-bsnz24jx	648	14	antibodies	antibody	NNS
cord-280549-bsnz24jx	648	15	revealed	reveal	VBD
cord-280549-bsnz24jx	648	16	that	that	IN
cord-280549-bsnz24jx	648	17	these	these	DT
cord-280549-bsnz24jx	648	18	two	two	CD
cord-280549-bsnz24jx	648	19	viral	viral	JJ
cord-280549-bsnz24jx	648	20	proteins	protein	NNS
cord-280549-bsnz24jx	648	21	,	,	,
cord-280549-bsnz24jx	648	22	which	which	WDT
cord-280549-bsnz24jx	648	23	are	be	VBP
cord-280549-bsnz24jx	648	24	expressed	express	VBN
cord-280549-bsnz24jx	648	25	on	on	IN
cord-280549-bsnz24jx	648	26	virus	virus	NN
cord-280549-bsnz24jx	648	27	-	-	HYPH
cord-280549-bsnz24jx	648	28	infected	infect	VBN
cord-280549-bsnz24jx	648	29	DCs	dc	NNS
cord-280549-bsnz24jx	648	30	,	,	,
cord-280549-bsnz24jx	648	31	are	be	VBP
cord-280549-bsnz24jx	648	32	responsible	responsible	JJ
cord-280549-bsnz24jx	648	33	for	for	IN
cord-280549-bsnz24jx	648	34	the	the	DT
cord-280549-bsnz24jx	648	35	suppression	suppression	NN
cord-280549-bsnz24jx	648	36	of	of	IN
cord-280549-bsnz24jx	648	37	T	t	NN
cord-280549-bsnz24jx	648	38	-	-	HYPH
cord-280549-bsnz24jx	648	39	cell	cell	NN
cord-280549-bsnz24jx	648	40	proliferation	proliferation	NN
cord-280549-bsnz24jx	648	41	(	(	-LRB-
cord-280549-bsnz24jx	648	42	Dubois	Dubois	NNP
cord-280549-bsnz24jx	648	43	et	et	NNP
cord-280549-bsnz24jx	648	44	al	al	NNP
cord-280549-bsnz24jx	648	45	.	.	NNP
cord-280549-bsnz24jx	648	46	,	,	,
cord-280549-bsnz24jx	648	47	2001	2001	CD
cord-280549-bsnz24jx	648	48	)	)	-RRB-
cord-280549-bsnz24jx	648	49	.	.	.
cord-280549-bsnz24jx	649	1	Thus	thus	RB
cord-280549-bsnz24jx	649	2	,	,	,
cord-280549-bsnz24jx	649	3	through	through	IN
cord-280549-bsnz24jx	649	4	surface	surface	NN
cord-280549-bsnz24jx	649	5	expression	expression	NN
cord-280549-bsnz24jx	649	6	of	of	IN
cord-280549-bsnz24jx	649	7	HA	HA	NNP
cord-280549-bsnz24jx	649	8	and	and	CC
cord-280549-bsnz24jx	649	9	F	F	NNP
cord-280549-bsnz24jx	649	10	on	on	IN
cord-280549-bsnz24jx	649	11	virus	virus	NN
cord-280549-bsnz24jx	649	12	-	-	HYPH
cord-280549-bsnz24jx	649	13	infected	infect	VBN
cord-280549-bsnz24jx	649	14	DCs	dc	NNS
cord-280549-bsnz24jx	649	15	,	,	,
cord-280549-bsnz24jx	649	16	MV	MV	NNP
cord-280549-bsnz24jx	649	17	takes	take	VBZ
cord-280549-bsnz24jx	649	18	a	a	DT
cord-280549-bsnz24jx	649	19	free	free	JJ
cord-280549-bsnz24jx	649	20	ride	ride	NN
cord-280549-bsnz24jx	649	21	on	on	IN
cord-280549-bsnz24jx	649	22	DCs	dc	NNS
cord-280549-bsnz24jx	649	23	to	to	TO
cord-280549-bsnz24jx	649	24	reach	reach	VB
cord-280549-bsnz24jx	649	25	draining	drain	VBG
cord-280549-bsnz24jx	649	26	lymph	lymph	NN
cord-280549-bsnz24jx	649	27	nodes	node	NNS
cord-280549-bsnz24jx	649	28	and	and	CC
cord-280549-bsnz24jx	649	29	subverts	subvert	VBZ
cord-280549-bsnz24jx	649	30	the	the	DT
cord-280549-bsnz24jx	649	31	normal	normal	JJ
cord-280549-bsnz24jx	649	32	function	function	NN
cord-280549-bsnz24jx	649	33	of	of	IN
cord-280549-bsnz24jx	649	34	DCs	dc	NNS
cord-280549-bsnz24jx	649	35	to	to	TO
cord-280549-bsnz24jx	649	36	inhibit	inhibit	VB
cord-280549-bsnz24jx	649	37	T	t	NN
cord-280549-bsnz24jx	649	38	-	-	HYPH
cord-280549-bsnz24jx	649	39	cell	cell	NN
cord-280549-bsnz24jx	649	40	proliferation	proliferation	NN
cord-280549-bsnz24jx	649	41	.	.	.
cord-280549-bsnz24jx	650	1	This	this	DT
cord-280549-bsnz24jx	650	2	infection	infection	NN
cord-280549-bsnz24jx	650	3	-	-	HYPH
cord-280549-bsnz24jx	650	4	independent	independent	JJ
cord-280549-bsnz24jx	650	5	action	action	NN
cord-280549-bsnz24jx	650	6	in	in	IN
cord-280549-bsnz24jx	650	7	T	T	NNP
cord-280549-bsnz24jx	650	8	cells	cell	NNS
cord-280549-bsnz24jx	650	9	results	result	NNS
cord-280549-bsnz24jx	650	10	in	in	IN
cord-280549-bsnz24jx	650	11	accumulation	accumulation	NN
cord-280549-bsnz24jx	650	12	of	of	IN
cord-280549-bsnz24jx	650	13	cells	cell	NNS
cord-280549-bsnz24jx	650	14	in	in	IN
cord-280549-bsnz24jx	650	15	G0	G0	NNP
cord-280549-bsnz24jx	650	16	/	/	SYM
cord-280549-bsnz24jx	650	17	G1	g1	NN
cord-280549-bsnz24jx	650	18	,	,	,
cord-280549-bsnz24jx	650	19	owing	owe	VBG
cord-280549-bsnz24jx	650	20	to	to	IN
cord-280549-bsnz24jx	650	21	the	the	DT
cord-280549-bsnz24jx	650	22	inhibition	inhibition	NN
cord-280549-bsnz24jx	650	23	of	of	IN
cord-280549-bsnz24jx	650	24	PI3	PI3	NNP
cord-280549-bsnz24jx	650	25	K	K	NNP
cord-280549-bsnz24jx	650	26	signaling	signal	VBG
cord-280549-bsnz24jx	650	27	in	in	IN
cord-280549-bsnz24jx	650	28	response	response	NN
cord-280549-bsnz24jx	650	29	to	to	IN
cord-280549-bsnz24jx	650	30	T	t	NN
cord-280549-bsnz24jx	650	31	-	-	HYPH
cord-280549-bsnz24jx	650	32	cell	cell	NN
cord-280549-bsnz24jx	650	33	receptor	receptor	NN
cord-280549-bsnz24jx	650	34	binding	bind	VBG
cord-280549-bsnz24jx	650	35	(	(	-LRB-
cord-280549-bsnz24jx	650	36	Griffin	Griffin	NNP
cord-280549-bsnz24jx	650	37	,	,	,
cord-280549-bsnz24jx	650	38	2010	2010	CD
cord-280549-bsnz24jx	650	39	)	)	-RRB-
cord-280549-bsnz24jx	650	40	.	.	.
cord-280549-bsnz24jx	651	1	Zika	Zika	NNP
cord-280549-bsnz24jx	651	2	virus	virus	NN
cord-280549-bsnz24jx	651	3	(	(	-LRB-
cord-280549-bsnz24jx	651	4	ZIKV	ZIKV	NNP
cord-280549-bsnz24jx	651	5	)	)	-RRB-
cord-280549-bsnz24jx	651	6	,	,	,
cord-280549-bsnz24jx	651	7	a	a	DT
cord-280549-bsnz24jx	651	8	flavivirus	flavivirus	NN
cord-280549-bsnz24jx	651	9	that	that	WDT
cord-280549-bsnz24jx	651	10	is	be	VBZ
cord-280549-bsnz24jx	651	11	transmitted	transmit	VBN
cord-280549-bsnz24jx	651	12	to	to	IN
cord-280549-bsnz24jx	651	13	humans	human	NNS
cord-280549-bsnz24jx	651	14	primarily	primarily	RB
cord-280549-bsnz24jx	651	15	by	by	IN
cord-280549-bsnz24jx	651	16	Aedes	Aedes	NNP
cord-280549-bsnz24jx	651	17	mosquitoes	mosquito	NNS
cord-280549-bsnz24jx	651	18	,	,	,
cord-280549-bsnz24jx	651	19	has	have	VBZ
cord-280549-bsnz24jx	651	20	been	be	VBN
cord-280549-bsnz24jx	651	21	shown	show	VBN
cord-280549-bsnz24jx	651	22	to	to	TO
cord-280549-bsnz24jx	651	23	cause	cause	VB
cord-280549-bsnz24jx	651	24	congenital	congenital	JJ
cord-280549-bsnz24jx	651	25	microcephaly	microcephaly	NNS
cord-280549-bsnz24jx	651	26	when	when	WRB
cord-280549-bsnz24jx	651	27	it	-PRON-	PRP
cord-280549-bsnz24jx	651	28	infects	infect	VBZ
cord-280549-bsnz24jx	651	29	women	woman	NNS
cord-280549-bsnz24jx	651	30	early	early	RB
cord-280549-bsnz24jx	651	31	in	in	IN
cord-280549-bsnz24jx	651	32	pregnancy	pregnancy	NN
cord-280549-bsnz24jx	651	33	(	(	-LRB-
cord-280549-bsnz24jx	651	34	de	de	FW
cord-280549-bsnz24jx	651	35	Araújo	Araújo	NNP
cord-280549-bsnz24jx	651	36	et	et	FW
cord-280549-bsnz24jx	651	37	al	al	NNP
cord-280549-bsnz24jx	651	38	.	.	NNP
cord-280549-bsnz24jx	651	39	,	,	,
cord-280549-bsnz24jx	651	40	2018	2018	CD
cord-280549-bsnz24jx	651	41	;	;	:
cord-280549-bsnz24jx	651	42	Hoen	Hoen	NNP
cord-280549-bsnz24jx	651	43	et	et	NNP
cord-280549-bsnz24jx	651	44	al	al	NNP
cord-280549-bsnz24jx	651	45	.	.	NNP
cord-280549-bsnz24jx	651	46	,	,	,
cord-280549-bsnz24jx	651	47	2018	2018	CD
cord-280549-bsnz24jx	651	48	)	)	-RRB-
cord-280549-bsnz24jx	651	49	.	.	.
cord-280549-bsnz24jx	652	1	This	this	DT
cord-280549-bsnz24jx	652	2	has	have	VBZ
cord-280549-bsnz24jx	652	3	led	lead	VBN
cord-280549-bsnz24jx	652	4	to	to	IN
cord-280549-bsnz24jx	652	5	a	a	DT
cord-280549-bsnz24jx	652	6	flurry	flurry	NN
cord-280549-bsnz24jx	652	7	of	of	IN
cord-280549-bsnz24jx	652	8	studies	study	NNS
cord-280549-bsnz24jx	652	9	in	in	IN
cord-280549-bsnz24jx	652	10	different	different	JJ
cord-280549-bsnz24jx	652	11	experimental	experimental	JJ
cord-280549-bsnz24jx	652	12	models	model	NNS
cord-280549-bsnz24jx	652	13	that	that	WDT
cord-280549-bsnz24jx	652	14	have	have	VBP
cord-280549-bsnz24jx	652	15	established	establish	VBN
cord-280549-bsnz24jx	652	16	the	the	DT
cord-280549-bsnz24jx	652	17	ZIKV	ZIKV	NNP
cord-280549-bsnz24jx	652	18	induces	induce	VBZ
cord-280549-bsnz24jx	652	19	massive	massive	JJ
cord-280549-bsnz24jx	652	20	abnormalities	abnormality	NNS
cord-280549-bsnz24jx	652	21	of	of	IN
cord-280549-bsnz24jx	652	22	cell	cell	NN
cord-280549-bsnz24jx	652	23	division	division	NN
cord-280549-bsnz24jx	652	24	,	,	,
cord-280549-bsnz24jx	652	25	including	include	VBG
cord-280549-bsnz24jx	652	26	the	the	DT
cord-280549-bsnz24jx	652	27	presence	presence	NN
cord-280549-bsnz24jx	652	28	of	of	IN
cord-280549-bsnz24jx	652	29	supernumerary	supernumerary	JJ
cord-280549-bsnz24jx	652	30	centrosomes	centrosome	NNS
cord-280549-bsnz24jx	652	31	,	,	,
cord-280549-bsnz24jx	652	32	that	that	DT
cord-280549-bsnz24jx	652	33	lead	lead	VBP
cord-280549-bsnz24jx	652	34	to	to	IN
cord-280549-bsnz24jx	652	35	virally	virally	RB
cord-280549-bsnz24jx	652	36	-	-	HYPH
cord-280549-bsnz24jx	652	37	induced	induce	VBN
cord-280549-bsnz24jx	652	38	caspase	caspase	NN
cord-280549-bsnz24jx	652	39	3-mediated	3-mediated	CD
cord-280549-bsnz24jx	652	40	apoptotic	apoptotic	JJ
cord-280549-bsnz24jx	652	41	cell	cell	NN
cord-280549-bsnz24jx	652	42	death	death	NN
cord-280549-bsnz24jx	652	43	and	and	CC
cord-280549-bsnz24jx	652	44	cell	cell	NN
cord-280549-bsnz24jx	652	45	cycle	cycle	NN
cord-280549-bsnz24jx	652	46	abnormalities	abnormality	NNS
cord-280549-bsnz24jx	652	47	of	of	IN
cord-280549-bsnz24jx	652	48	human	human	JJ
cord-280549-bsnz24jx	652	49	neural	neural	JJ
cord-280549-bsnz24jx	652	50	progenitor	progenitor	NN
cord-280549-bsnz24jx	652	51	cells	cell	NNS
cord-280549-bsnz24jx	652	52	(	(	-LRB-
cord-280549-bsnz24jx	652	53	Faizan	faizan	NN
cord-280549-bsnz24jx	652	54	et	et	NNP
cord-280549-bsnz24jx	652	55	al	al	NNP
cord-280549-bsnz24jx	652	56	.	.	NNP
cord-280549-bsnz24jx	652	57	,	,	,
cord-280549-bsnz24jx	652	58	2016	2016	CD
cord-280549-bsnz24jx	652	59	;	;	:
cord-280549-bsnz24jx	652	60	Souza	Souza	NNP
cord-280549-bsnz24jx	652	61	et	et	NNP
cord-280549-bsnz24jx	652	62	al	al	NNP
cord-280549-bsnz24jx	652	63	.	.	.
cord-280549-bsnz24jx	653	1	,	,	,
cord-280549-bsnz24jx	653	2	2016	2016	CD
cord-280549-bsnz24jx	653	3	;	;	:
cord-280549-bsnz24jx	653	4	Gabriel	Gabriel	NNP
cord-280549-bsnz24jx	653	5	et	et	NNP
cord-280549-bsnz24jx	653	6	al	al	NNP
cord-280549-bsnz24jx	653	7	.	.	NNP
cord-280549-bsnz24jx	653	8	,	,	,
cord-280549-bsnz24jx	653	9	2017	2017	CD
cord-280549-bsnz24jx	653	10	)	)	-RRB-
cord-280549-bsnz24jx	653	11	,	,	,
cord-280549-bsnz24jx	653	12	although	although	IN
cord-280549-bsnz24jx	653	13	how	how	WRB
cord-280549-bsnz24jx	653	14	it	-PRON-	PRP
cord-280549-bsnz24jx	653	15	interferes	interfere	VBZ
cord-280549-bsnz24jx	653	16	with	with	IN
cord-280549-bsnz24jx	653	17	the	the	DT
cord-280549-bsnz24jx	653	18	cell	cell	NN
cord-280549-bsnz24jx	653	19	cycle	cycle	NN
cord-280549-bsnz24jx	653	20	has	have	VBZ
cord-280549-bsnz24jx	653	21	not	not	RB
cord-280549-bsnz24jx	653	22	been	be	VBN
cord-280549-bsnz24jx	653	23	precisely	precisely	RB
cord-280549-bsnz24jx	653	24	defined	define	VBN
cord-280549-bsnz24jx	653	25	.	.	.
cord-280549-bsnz24jx	654	1	Moreover	moreover	RB
cord-280549-bsnz24jx	654	2	,	,	,
cord-280549-bsnz24jx	654	3	transcriptional	transcriptional	JJ
cord-280549-bsnz24jx	654	4	profiling	profiling	NN
cord-280549-bsnz24jx	654	5	of	of	IN
cord-280549-bsnz24jx	654	6	infected	infected	JJ
cord-280549-bsnz24jx	654	7	human	human	JJ
cord-280549-bsnz24jx	654	8	neural	neural	JJ
cord-280549-bsnz24jx	654	9	progenitor	progenitor	NN
cord-280549-bsnz24jx	654	10	cells	cell	NNS
cord-280549-bsnz24jx	654	11	has	have	VBZ
cord-280549-bsnz24jx	654	12	revealed	reveal	VBN
cord-280549-bsnz24jx	654	13	a	a	DT
cord-280549-bsnz24jx	654	14	dysregulation	dysregulation	NN
cord-280549-bsnz24jx	654	15	of	of	IN
cord-280549-bsnz24jx	654	16	cell	cell	NN
cord-280549-bsnz24jx	654	17	cycle	cycle	NN
cord-280549-bsnz24jx	654	18	-	-	:
cord-280549-bsnz24jx	654	19	and	and	CC
cord-280549-bsnz24jx	654	20	differentiation	differentiation	NN
cord-280549-bsnz24jx	654	21	-	-	HYPH
cord-280549-bsnz24jx	654	22	related	relate	VBN
cord-280549-bsnz24jx	654	23	pathways	pathway	NNS
cord-280549-bsnz24jx	654	24	in	in	IN
cord-280549-bsnz24jx	654	25	neural	neural	JJ
cord-280549-bsnz24jx	654	26	progenitor	progenitor	NN
cord-280549-bsnz24jx	654	27	cells	cell	NNS
cord-280549-bsnz24jx	655	1	(	(	-LRB-
cord-280549-bsnz24jx	655	2	Dang	dang	UH
cord-280549-bsnz24jx	655	3	et	et	FW
cord-280549-bsnz24jx	655	4	al	al	NNP
cord-280549-bsnz24jx	655	5	.	.	NNP
cord-280549-bsnz24jx	655	6	,	,	,
cord-280549-bsnz24jx	655	7	2016	2016	CD
cord-280549-bsnz24jx	655	8	;	;	:
cord-280549-bsnz24jx	655	9	Li	Li	NNP
cord-280549-bsnz24jx	655	10	et	et	NNP
cord-280549-bsnz24jx	655	11	al	al	NNP
cord-280549-bsnz24jx	655	12	.	.	NNP
cord-280549-bsnz24jx	655	13	,	,	,
cord-280549-bsnz24jx	655	14	2016	2016	CD
cord-280549-bsnz24jx	655	15	;	;	.
cord-280549-bsnz24jx	656	1	Tang	Tang	NNP
cord-280549-bsnz24jx	656	2	et	et	NNP
cord-280549-bsnz24jx	656	3	al	al	NNP
cord-280549-bsnz24jx	656	4	.	.	NNP
cord-280549-bsnz24jx	656	5	,	,	,
cord-280549-bsnz24jx	656	6	2016	2016	CD
cord-280549-bsnz24jx	656	7	)	)	-RRB-
cord-280549-bsnz24jx	656	8	.	.	.
cord-280549-bsnz24jx	657	1	Interestingly	interestingly	RB
cord-280549-bsnz24jx	657	2	,	,	,
cord-280549-bsnz24jx	657	3	it	-PRON-	PRP
cord-280549-bsnz24jx	657	4	has	have	VBZ
cord-280549-bsnz24jx	657	5	been	be	VBN
cord-280549-bsnz24jx	657	6	observed	observe	VBN
cord-280549-bsnz24jx	657	7	that	that	IN
cord-280549-bsnz24jx	657	8	an	an	DT
cord-280549-bsnz24jx	657	9	antiproliferactive	antiproliferactive	JJ
cord-280549-bsnz24jx	657	10	and	and	CC
cord-280549-bsnz24jx	657	11	pro	pro	JJ
cord-280549-bsnz24jx	657	12	-	-	JJ
cord-280549-bsnz24jx	657	13	apoptotic	apoptotic	JJ
cord-280549-bsnz24jx	657	14	p53-related	p53-related	JJ
cord-280549-bsnz24jx	657	15	response	response	NN
cord-280549-bsnz24jx	657	16	markedly	markedly	RB
cord-280549-bsnz24jx	657	17	different	different	JJ
cord-280549-bsnz24jx	657	18	from	from	IN
cord-280549-bsnz24jx	657	19	p53-induced	p53-induced	JJ
cord-280549-bsnz24jx	657	20	transcriptional	transcriptional	JJ
cord-280549-bsnz24jx	657	21	changes	change	NNS
cord-280549-bsnz24jx	657	22	upon	upon	IN
cord-280549-bsnz24jx	657	23	infection	infection	NN
cord-280549-bsnz24jx	657	24	by	by	IN
cord-280549-bsnz24jx	657	25	HCMV	HCMV	NNP
cord-280549-bsnz24jx	657	26	,	,	,
cord-280549-bsnz24jx	657	27	which	which	WDT
cord-280549-bsnz24jx	657	28	can	can	MD
cord-280549-bsnz24jx	657	29	also	also	RB
cord-280549-bsnz24jx	657	30	cause	cause	VB
cord-280549-bsnz24jx	657	31	microcephaly	microcephaly	NNS
cord-280549-bsnz24jx	657	32	,	,	,
cord-280549-bsnz24jx	657	33	is	be	VBZ
cord-280549-bsnz24jx	657	34	activated	activate	VBN
cord-280549-bsnz24jx	657	35	in	in	IN
cord-280549-bsnz24jx	657	36	ZIKA	ZIKA	NNP
cord-280549-bsnz24jx	657	37	-	-	HYPH
cord-280549-bsnz24jx	657	38	infected	infect	VBN
cord-280549-bsnz24jx	657	39	human	human	JJ
cord-280549-bsnz24jx	657	40	neural	neural	JJ
cord-280549-bsnz24jx	657	41	progenitor	progenitor	NN
cord-280549-bsnz24jx	657	42	cells	cell	NNS
cord-280549-bsnz24jx	657	43	(	(	-LRB-
cord-280549-bsnz24jx	657	44	Ghouzzi	Ghouzzi	NNP
cord-280549-bsnz24jx	657	45	et	et	NNP
cord-280549-bsnz24jx	657	46	al	al	NNP
cord-280549-bsnz24jx	657	47	.	.	NNP
cord-280549-bsnz24jx	657	48	,	,	,
cord-280549-bsnz24jx	657	49	2016	2016	CD
cord-280549-bsnz24jx	657	50	)	)	-RRB-
cord-280549-bsnz24jx	657	51	.	.	.
cord-280549-bsnz24jx	658	1	More	more	RBR
cord-280549-bsnz24jx	658	2	recently	recently	RB
cord-280549-bsnz24jx	658	3	,	,	,
cord-280549-bsnz24jx	658	4	by	by	IN
cord-280549-bsnz24jx	658	5	investigating	investigate	VBG
cord-280549-bsnz24jx	658	6	the	the	DT
cord-280549-bsnz24jx	658	7	effect	effect	NN
cord-280549-bsnz24jx	658	8	of	of	IN
cord-280549-bsnz24jx	658	9	individual	individual	JJ
cord-280549-bsnz24jx	658	10	ZIKV	zikv	NN
cord-280549-bsnz24jx	658	11	proteins	protein	NNS
cord-280549-bsnz24jx	658	12	in	in	IN
cord-280549-bsnz24jx	658	13	vitro	vitro	FW
cord-280549-bsnz24jx	658	14	,	,	,
cord-280549-bsnz24jx	658	15	it	-PRON-	PRP
cord-280549-bsnz24jx	658	16	was	be	VBD
cord-280549-bsnz24jx	658	17	found	find	VBN
cord-280549-bsnz24jx	658	18	that	that	DT
cord-280549-bsnz24jx	658	19	expression	expression	NN
cord-280549-bsnz24jx	658	20	of	of	IN
cord-280549-bsnz24jx	658	21	the	the	DT
cord-280549-bsnz24jx	658	22	membrane	membrane	NN
cord-280549-bsnz24jx	658	23	-	-	HYPH
cord-280549-bsnz24jx	658	24	anchored	anchor	VBN
cord-280549-bsnz24jx	658	25	capsid	capsid	NN
cord-280549-bsnz24jx	658	26	anaC	anac	NN
cord-280549-bsnz24jx	658	27	,	,	,
cord-280549-bsnz24jx	658	28	structural	structural	JJ
cord-280549-bsnz24jx	658	29	envelope	envelope	NN
cord-280549-bsnz24jx	658	30	E	e	NN
cord-280549-bsnz24jx	658	31	,	,	,
cord-280549-bsnz24jx	658	32	membrane	membrane	NN
cord-280549-bsnz24jx	658	33	M	m	CD
cord-280549-bsnz24jx	658	34	proteins	protein	NNS
cord-280549-bsnz24jx	658	35	,	,	,
cord-280549-bsnz24jx	658	36	and	and	CC
cord-280549-bsnz24jx	658	37	nonstructural	nonstructural	JJ
cord-280549-bsnz24jx	658	38	protein	protein	NN
cord-280549-bsnz24jx	658	39	4A	4a	CD
cord-280549-bsnz24jx	658	40	(	(	-LRB-
cord-280549-bsnz24jx	658	41	NS4A	ns4a	NN
cord-280549-bsnz24jx	658	42	)	)	-RRB-
cord-280549-bsnz24jx	658	43	could	could	MD
cord-280549-bsnz24jx	658	44	trigger	trigger	VB
cord-280549-bsnz24jx	658	45	G2	G2	NNP
cord-280549-bsnz24jx	658	46	/	/	SYM
cord-280549-bsnz24jx	658	47	M	M	NNP
cord-280549-bsnz24jx	658	48	cell	cell	NN
cord-280549-bsnz24jx	658	49	cycle	cycle	NN
cord-280549-bsnz24jx	658	50	arrest	arrest	NN
cord-280549-bsnz24jx	658	51	and	and	CC
cord-280549-bsnz24jx	658	52	apoptosis	apoptosis	NN
cord-280549-bsnz24jx	658	53	(	(	-LRB-
cord-280549-bsnz24jx	658	54	Li	Li	NNP
cord-280549-bsnz24jx	658	55	et	et	NNP
cord-280549-bsnz24jx	658	56	al	al	NNP
cord-280549-bsnz24jx	658	57	.	.	NNP
cord-280549-bsnz24jx	658	58	,	,	,
cord-280549-bsnz24jx	658	59	2017	2017	CD
cord-280549-bsnz24jx	658	60	;	;	:
cord-280549-bsnz24jx	658	61	Liu	Liu	NNP
cord-280549-bsnz24jx	658	62	et	et	NNP
cord-280549-bsnz24jx	658	63	al	al	NNP
cord-280549-bsnz24jx	658	64	.	.	NNP
cord-280549-bsnz24jx	658	65	,	,	,
cord-280549-bsnz24jx	658	66	2018	2018	CD
cord-280549-bsnz24jx	658	67	)	)	-RRB-
cord-280549-bsnz24jx	658	68	.	.	.
cord-280549-bsnz24jx	659	1	The	the	DT
cord-280549-bsnz24jx	659	2	NS4A	NS4A	NNP
cord-280549-bsnz24jx	659	3	induces	induce	VBZ
cord-280549-bsnz24jx	659	4	growth	growth	NN
cord-280549-bsnz24jx	659	5	restriction	restriction	NN
cord-280549-bsnz24jx	659	6	via	via	IN
cord-280549-bsnz24jx	659	7	the	the	DT
cord-280549-bsnz24jx	659	8	target	target	NN
cord-280549-bsnz24jx	659	9	of	of	IN
cord-280549-bsnz24jx	659	10	rapamycin	rapamycin	NN
cord-280549-bsnz24jx	659	11	(	(	-LRB-
cord-280549-bsnz24jx	659	12	TOR	TOR	NNP
cord-280549-bsnz24jx	659	13	)	)	-RRB-
cord-280549-bsnz24jx	659	14	cellular	cellular	JJ
cord-280549-bsnz24jx	659	15	stress	stress	NN
cord-280549-bsnz24jx	659	16	pathway	pathway	NN
cord-280549-bsnz24jx	659	17	(	(	-LRB-
cord-280549-bsnz24jx	659	18	Li	Li	NNP
cord-280549-bsnz24jx	659	19	et	et	NNP
cord-280549-bsnz24jx	659	20	al	al	NNP
cord-280549-bsnz24jx	659	21	.	.	NNP
cord-280549-bsnz24jx	659	22	,	,	,
cord-280549-bsnz24jx	659	23	2017	2017	CD
cord-280549-bsnz24jx	659	24	)	)	-RRB-
cord-280549-bsnz24jx	659	25	,	,	,
cord-280549-bsnz24jx	659	26	whereas	whereas	IN
cord-280549-bsnz24jx	659	27	envelopetriggered	envelopetriggere	VBN
cord-280549-bsnz24jx	659	28	apoptosis	apoptosis	NN
cord-280549-bsnz24jx	659	29	is	be	VBZ
cord-280549-bsnz24jx	659	30	associated	associate	VBN
cord-280549-bsnz24jx	659	31	with	with	IN
cord-280549-bsnz24jx	659	32	upregulation	upregulation	NN
cord-280549-bsnz24jx	659	33	of	of	IN
cord-280549-bsnz24jx	659	34	both	both	DT
cord-280549-bsnz24jx	659	35	p53	p53	NN
cord-280549-bsnz24jx	659	36	and	and	CC
cord-280549-bsnz24jx	659	37	p21	p21	NN
cord-280549-bsnz24jx	659	38	Cip1	Cip1	NNP
cord-280549-bsnz24jx	659	39	/	/	.
cord-280549-bsnz24jx	660	1	Waf1	waf1	NN
cord-280549-bsnz24jx	660	2	and	and	CC
cord-280549-bsnz24jx	660	3	downregulation	downregulation	NN
cord-280549-bsnz24jx	660	4	of	of	IN
cord-280549-bsnz24jx	660	5	cyclin	cyclin	NN
cord-280549-bsnz24jx	660	6	B1	b1	NN
cord-280549-bsnz24jx	660	7	.	.	.
cord-280549-bsnz24jx	661	1	Interestingly	interestingly	RB
cord-280549-bsnz24jx	661	2	,	,	,
cord-280549-bsnz24jx	661	3	ZIKA	ZIKA	NNP
cord-280549-bsnz24jx	661	4	membrane	membrane	NN
cord-280549-bsnz24jx	661	5	protein	protein	NN
cord-280549-bsnz24jx	661	6	(	(	-LRB-
cord-280549-bsnz24jx	661	7	M	M	NNP
cord-280549-bsnz24jx	661	8	)	)	-RRB-
cord-280549-bsnz24jx	661	9	induce	induce	VBP
cord-280549-bsnz24jx	661	10	arrest	arrest	NN
cord-280549-bsnz24jx	661	11	of	of	IN
cord-280549-bsnz24jx	661	12	the	the	DT
cord-280549-bsnz24jx	661	13	cell	cell	NN
cord-280549-bsnz24jx	661	14	cycle	cycle	NN
cord-280549-bsnz24jx	661	15	in	in	IN
cord-280549-bsnz24jx	661	16	G2	G2	NNP
cord-280549-bsnz24jx	661	17	/	/	SYM
cord-280549-bsnz24jx	661	18	M	M	NNP
cord-280549-bsnz24jx	661	19	,	,	,
cord-280549-bsnz24jx	661	20	whereas	whereas	IN
cord-280549-bsnz24jx	661	21	the	the	DT
cord-280549-bsnz24jx	661	22	pre	pre	JJ
cord-280549-bsnz24jx	661	23	-	-	NN
cord-280549-bsnz24jx	661	24	membrane	membrane	JJ
cord-280549-bsnz24jx	661	25	protein	protein	NN
cord-280549-bsnz24jx	661	26	(	(	-LRB-
cord-280549-bsnz24jx	661	27	prM	prm	JJ
cord-280549-bsnz24jx	661	28	)	)	-RRB-
cord-280549-bsnz24jx	661	29	results	result	NNS
cord-280549-bsnz24jx	661	30	in	in	IN
cord-280549-bsnz24jx	661	31	G1	G1	NNP
cord-280549-bsnz24jx	661	32	accumulation	accumulation	NN
cord-280549-bsnz24jx	662	1	(	(	-LRB-
cord-280549-bsnz24jx	662	2	Li	Li	NNP
cord-280549-bsnz24jx	662	3	et	et	NNP
cord-280549-bsnz24jx	662	4	al	al	NNP
cord-280549-bsnz24jx	662	5	.	.	NNP
cord-280549-bsnz24jx	662	6	,	,	,
cord-280549-bsnz24jx	662	7	2017	2017	CD
cord-280549-bsnz24jx	662	8	)	)	-RRB-
cord-280549-bsnz24jx	662	9	,	,	,
cord-280549-bsnz24jx	662	10	revealing	reveal	VBG
cord-280549-bsnz24jx	662	11	that	that	IN
cord-280549-bsnz24jx	662	12	posttranslational	posttranslational	JJ
cord-280549-bsnz24jx	662	13	processing	processing	NN
cord-280549-bsnz24jx	662	14	modifies	modify	VBZ
cord-280549-bsnz24jx	662	15	its	-PRON-	PRP$
cord-280549-bsnz24jx	662	16	interference	interference	NN
cord-280549-bsnz24jx	662	17	with	with	IN
cord-280549-bsnz24jx	662	18	cell	cell	NN
cord-280549-bsnz24jx	662	19	cycle	cycle	NN
cord-280549-bsnz24jx	662	20	progression	progression	NN
cord-280549-bsnz24jx	662	21	.	.	.
cord-280549-bsnz24jx	663	1	The	the	DT
cord-280549-bsnz24jx	663	2	interplay	interplay	NN
cord-280549-bsnz24jx	663	3	between	between	IN
cord-280549-bsnz24jx	663	4	the	the	DT
cord-280549-bsnz24jx	663	5	life	life	NN
cord-280549-bsnz24jx	663	6	cycle	cycle	NN
cord-280549-bsnz24jx	663	7	of	of	IN
cord-280549-bsnz24jx	663	8	viruses	virus	NNS
cord-280549-bsnz24jx	663	9	and	and	CC
cord-280549-bsnz24jx	663	10	the	the	DT
cord-280549-bsnz24jx	663	11	series	series	NN
cord-280549-bsnz24jx	663	12	of	of	IN
cord-280549-bsnz24jx	663	13	events	event	NNS
cord-280549-bsnz24jx	663	14	leading	lead	VBG
cord-280549-bsnz24jx	663	15	to	to	IN
cord-280549-bsnz24jx	663	16	cell	cell	NN
cord-280549-bsnz24jx	663	17	division	division	NN
cord-280549-bsnz24jx	663	18	has	have	VBZ
cord-280549-bsnz24jx	663	19	been	be	VBN
cord-280549-bsnz24jx	663	20	actively	actively	RB
cord-280549-bsnz24jx	663	21	investigated	investigate	VBN
cord-280549-bsnz24jx	663	22	since	since	IN
cord-280549-bsnz24jx	663	23	the	the	DT
cord-280549-bsnz24jx	663	24	discovery	discovery	NN
cord-280549-bsnz24jx	663	25	that	that	IN
cord-280549-bsnz24jx	663	26	certain	certain	JJ
cord-280549-bsnz24jx	663	27	tumors	tumor	NNS
cord-280549-bsnz24jx	663	28	were	be	VBD
cord-280549-bsnz24jx	663	29	associated	associate	VBN
cord-280549-bsnz24jx	663	30	to	to	IN
cord-280549-bsnz24jx	663	31	viral	viral	JJ
cord-280549-bsnz24jx	663	32	infection	infection	NN
cord-280549-bsnz24jx	663	33	.	.	.
cord-280549-bsnz24jx	664	1	Although	although	IN
cord-280549-bsnz24jx	664	2	estimates	estimate	NNS
cord-280549-bsnz24jx	664	3	of	of	IN
cord-280549-bsnz24jx	664	4	the	the	DT
cord-280549-bsnz24jx	664	5	incidence	incidence	NN
cord-280549-bsnz24jx	664	6	of	of	IN
cord-280549-bsnz24jx	664	7	cancers	cancer	NNS
cord-280549-bsnz24jx	664	8	caused	cause	VBN
cord-280549-bsnz24jx	664	9	by	by	IN
cord-280549-bsnz24jx	664	10	viruses	virus	NNS
cord-280549-bsnz24jx	664	11	vary	vary	VBP
cord-280549-bsnz24jx	664	12	,	,	,
cord-280549-bsnz24jx	664	13	both	both	CC
cord-280549-bsnz24jx	664	14	DNA	DNA	NNP
cord-280549-bsnz24jx	664	15	and	and	CC
cord-280549-bsnz24jx	664	16	RNA	RNA	NNP
cord-280549-bsnz24jx	664	17	viruses	virus	NNS
cord-280549-bsnz24jx	664	18	have	have	VBP
cord-280549-bsnz24jx	664	19	been	be	VBN
cord-280549-bsnz24jx	664	20	clearly	clearly	RB
cord-280549-bsnz24jx	664	21	linked	link	VBN
cord-280549-bsnz24jx	664	22	to	to	IN
cord-280549-bsnz24jx	664	23	the	the	DT
cord-280549-bsnz24jx	664	24	development	development	NN
cord-280549-bsnz24jx	664	25	of	of	IN
cord-280549-bsnz24jx	664	26	human	human	JJ
cord-280549-bsnz24jx	664	27	cancers	cancer	NNS
cord-280549-bsnz24jx	664	28	(	(	-LRB-
cord-280549-bsnz24jx	664	29	Liao	Liao	NNP
cord-280549-bsnz24jx	664	30	,	,	,
cord-280549-bsnz24jx	664	31	2006	2006	CD
cord-280549-bsnz24jx	664	32	;	;	:
cord-280549-bsnz24jx	664	33	Mesri	Mesri	NNP
cord-280549-bsnz24jx	664	34	et	et	NNP
cord-280549-bsnz24jx	664	35	al	al	NNP
cord-280549-bsnz24jx	664	36	.	.	NNP
cord-280549-bsnz24jx	664	37	,	,	,
cord-280549-bsnz24jx	664	38	2014	2014	CD
cord-280549-bsnz24jx	664	39	)	)	-RRB-
cord-280549-bsnz24jx	664	40	.	.	.
cord-280549-bsnz24jx	665	1	However	however	RB
cord-280549-bsnz24jx	665	2	,	,	,
cord-280549-bsnz24jx	665	3	most	most	JJS
cord-280549-bsnz24jx	665	4	viruses	virus	NNS
cord-280549-bsnz24jx	665	5	have	have	VBP
cord-280549-bsnz24jx	665	6	evolved	evolve	VBN
cord-280549-bsnz24jx	665	7	a	a	DT
cord-280549-bsnz24jx	665	8	more	more	RBR
cord-280549-bsnz24jx	665	9	complicated	complicated	JJ
cord-280549-bsnz24jx	665	10	relationship	relationship	NN
cord-280549-bsnz24jx	665	11	with	with	IN
cord-280549-bsnz24jx	665	12	the	the	DT
cord-280549-bsnz24jx	665	13	cell	cell	NN
cord-280549-bsnz24jx	665	14	cycle	cycle	NN
cord-280549-bsnz24jx	665	15	contenting	content	VBG
cord-280549-bsnz24jx	665	16	themselves	-PRON-	PRP
cord-280549-bsnz24jx	665	17	with	with	IN
cord-280549-bsnz24jx	665	18	surreptitious	surreptitious	JJ
cord-280549-bsnz24jx	665	19	tampering	tampering	NN
cord-280549-bsnz24jx	665	20	for	for	IN
cord-280549-bsnz24jx	665	21	more	more	JJR
cord-280549-bsnz24jx	665	22	effective	effective	JJ
cord-280549-bsnz24jx	665	23	replication	replication	NN
cord-280549-bsnz24jx	665	24	and	and	CC
cord-280549-bsnz24jx	665	25	productive	productive	JJ
cord-280549-bsnz24jx	665	26	infection	infection	NN
cord-280549-bsnz24jx	665	27	,	,	,
cord-280549-bsnz24jx	665	28	without	without	IN
cord-280549-bsnz24jx	665	29	leading	lead	VBG
cord-280549-bsnz24jx	665	30	to	to	IN
cord-280549-bsnz24jx	665	31	cell	cell	NN
cord-280549-bsnz24jx	665	32	transformation	transformation	NN
cord-280549-bsnz24jx	665	33	and	and	CC
cord-280549-bsnz24jx	665	34	tumorigenesis	tumorigenesis	NN
cord-280549-bsnz24jx	665	35	.	.	.
cord-280549-bsnz24jx	666	1	The	the	DT
cord-280549-bsnz24jx	666	2	most	most	RBS
cord-280549-bsnz24jx	666	3	obvious	obvious	JJ
cord-280549-bsnz24jx	666	4	mechanism	mechanism	NN
cord-280549-bsnz24jx	666	5	is	be	VBZ
cord-280549-bsnz24jx	666	6	the	the	DT
cord-280549-bsnz24jx	666	7	direct	direct	JJ
cord-280549-bsnz24jx	666	8	interaction	interaction	NN
cord-280549-bsnz24jx	666	9	of	of	IN
cord-280549-bsnz24jx	666	10	a	a	DT
cord-280549-bsnz24jx	666	11	viral	viral	JJ
cord-280549-bsnz24jx	666	12	gene	gene	NN
cord-280549-bsnz24jx	666	13	product	product	NN
cord-280549-bsnz24jx	666	14	with	with	IN
cord-280549-bsnz24jx	666	15	a	a	DT
cord-280549-bsnz24jx	666	16	host	host	NN
cord-280549-bsnz24jx	666	17	protein	protein	NN
cord-280549-bsnz24jx	666	18	to	to	TO
cord-280549-bsnz24jx	666	19	disarm	disarm	VB
cord-280549-bsnz24jx	666	20	its	-PRON-	PRP$
cord-280549-bsnz24jx	666	21	function	function	NN
cord-280549-bsnz24jx	666	22	,	,	,
cord-280549-bsnz24jx	666	23	which	which	WDT
cord-280549-bsnz24jx	666	24	has	have	VBZ
cord-280549-bsnz24jx	666	25	been	be	VBN
cord-280549-bsnz24jx	666	26	adopted	adopt	VBN
cord-280549-bsnz24jx	666	27	by	by	IN
cord-280549-bsnz24jx	666	28	many	many	JJ
cord-280549-bsnz24jx	666	29	viruses	virus	NNS
cord-280549-bsnz24jx	666	30	as	as	IN
cord-280549-bsnz24jx	666	31	a	a	DT
cord-280549-bsnz24jx	666	32	common	common	JJ
cord-280549-bsnz24jx	666	33	strategy	strategy	NN
cord-280549-bsnz24jx	666	34	to	to	TO
cord-280549-bsnz24jx	666	35	exploit	exploit	VB
cord-280549-bsnz24jx	666	36	host	host	NN
cord-280549-bsnz24jx	666	37	cell	cell	NN
cord-280549-bsnz24jx	666	38	cycle	cycle	NN
cord-280549-bsnz24jx	666	39	.	.	.
cord-280549-bsnz24jx	667	1	It	-PRON-	PRP
cord-280549-bsnz24jx	667	2	is	be	VBZ
cord-280549-bsnz24jx	667	3	commonly	commonly	RB
cord-280549-bsnz24jx	667	4	held	hold	VBN
cord-280549-bsnz24jx	667	5	that	that	IN
cord-280549-bsnz24jx	667	6	,	,	,
cord-280549-bsnz24jx	667	7	by	by	IN
cord-280549-bsnz24jx	667	8	interacting	interact	VBG
cord-280549-bsnz24jx	667	9	with	with	IN
cord-280549-bsnz24jx	667	10	cell	cell	NN
cord-280549-bsnz24jx	667	11	cycle	cycle	NN
cord-280549-bsnz24jx	667	12	regulators	regulator	NNS
cord-280549-bsnz24jx	667	13	and	and	CC
cord-280549-bsnz24jx	667	14	delaying	delay	VBG
cord-280549-bsnz24jx	667	15	cell	cell	NN
cord-280549-bsnz24jx	667	16	division	division	NN
cord-280549-bsnz24jx	667	17	,	,	,
cord-280549-bsnz24jx	667	18	these	these	DT
cord-280549-bsnz24jx	667	19	viruses	virus	NNS
cord-280549-bsnz24jx	667	20	can	can	MD
cord-280549-bsnz24jx	667	21	subvert	subvert	VB
cord-280549-bsnz24jx	667	22	the	the	DT
cord-280549-bsnz24jx	667	23	biosynthetic	biosynthetic	NN
cord-280549-bsnz24jx	667	24	apparatus	apparatus	NN
cord-280549-bsnz24jx	667	25	,	,	,
cord-280549-bsnz24jx	667	26	re	re	VBN
cord-280549-bsnz24jx	667	27	-	-	NN
cord-280549-bsnz24jx	667	28	directing	direct	VBG
cord-280549-bsnz24jx	667	29	it	-PRON-	PRP
cord-280549-bsnz24jx	667	30	from	from	IN
cord-280549-bsnz24jx	667	31	the	the	DT
cord-280549-bsnz24jx	667	32	production	production	NN
cord-280549-bsnz24jx	667	33	of	of	IN
cord-280549-bsnz24jx	667	34	host	host	NN
cord-280549-bsnz24jx	667	35	proteins	protein	NNS
cord-280549-bsnz24jx	667	36	needed	need	VBN
cord-280549-bsnz24jx	667	37	for	for	IN
cord-280549-bsnz24jx	667	38	cell	cell	NN
cord-280549-bsnz24jx	667	39	cycle	cycle	NN
cord-280549-bsnz24jx	667	40	progression	progression	NN
cord-280549-bsnz24jx	667	41	to	to	TO
cord-280549-bsnz24jx	667	42	suit	suit	VB
cord-280549-bsnz24jx	667	43	their	-PRON-	PRP$
cord-280549-bsnz24jx	667	44	replication	replication	NN
cord-280549-bsnz24jx	667	45	needs	need	NNS
cord-280549-bsnz24jx	667	46	.	.	.
cord-280549-bsnz24jx	668	1	Viruses	virus	NNS
cord-280549-bsnz24jx	668	2	stop	stop	VBP
cord-280549-bsnz24jx	668	3	at	at	IN
cord-280549-bsnz24jx	668	4	nothing	nothing	NN
cord-280549-bsnz24jx	668	5	and	and	CC
cord-280549-bsnz24jx	668	6	use	use	VB
cord-280549-bsnz24jx	668	7	any	any	DT
cord-280549-bsnz24jx	668	8	means	mean	NNS
cord-280549-bsnz24jx	668	9	necessary	necessary	JJ
cord-280549-bsnz24jx	668	10	to	to	TO
cord-280549-bsnz24jx	668	11	survive	survive	VB
cord-280549-bsnz24jx	668	12	in	in	IN
cord-280549-bsnz24jx	668	13	a	a	DT
cord-280549-bsnz24jx	668	14	hostile	hostile	JJ
cord-280549-bsnz24jx	668	15	environment	environment	NN
cord-280549-bsnz24jx	668	16	by	by	IN
cord-280549-bsnz24jx	668	17	inducing	induce	VBG
cord-280549-bsnz24jx	668	18	posttranslational	posttranslational	JJ
cord-280549-bsnz24jx	668	19	modifications	modification	NNS
cord-280549-bsnz24jx	668	20	and	and	CC
cord-280549-bsnz24jx	668	21	dislocating	dislocate	VBG
cord-280549-bsnz24jx	668	22	host	host	NN
cord-280549-bsnz24jx	668	23	restriction	restriction	NN
cord-280549-bsnz24jx	668	24	factors	factor	NNS
cord-280549-bsnz24jx	668	25	to	to	TO
cord-280549-bsnz24jx	668	26	modulate	modulate	VB
cord-280549-bsnz24jx	668	27	their	-PRON-	PRP$
cord-280549-bsnz24jx	668	28	function	function	NN
cord-280549-bsnz24jx	668	29	and/or	and/or	CC
cord-280549-bsnz24jx	668	30	degradation	degradation	NN
cord-280549-bsnz24jx	668	31	.	.	.
cord-280549-bsnz24jx	669	1	Co	co	NN
cord-280549-bsnz24jx	669	2	-	-	NN
cord-280549-bsnz24jx	669	3	evolution	evolution	NN
cord-280549-bsnz24jx	669	4	and	and	CC
cord-280549-bsnz24jx	669	5	adaptation	adaptation	NN
cord-280549-bsnz24jx	669	6	of	of	IN
cord-280549-bsnz24jx	669	7	virus	virus	NN
cord-280549-bsnz24jx	669	8	-	-	HYPH
cord-280549-bsnz24jx	669	9	host	host	NN
cord-280549-bsnz24jx	669	10	interactions	interaction	NNS
cord-280549-bsnz24jx	669	11	is	be	VBZ
cord-280549-bsnz24jx	669	12	best	well	RBS
cord-280549-bsnz24jx	669	13	described	describe	VBN
cord-280549-bsnz24jx	669	14	as	as	IN
cord-280549-bsnz24jx	669	15	a	a	DT
cord-280549-bsnz24jx	669	16	zero	zero	CD
cord-280549-bsnz24jx	669	17	-	-	HYPH
cord-280549-bsnz24jx	669	18	sum	sum	NN
cord-280549-bsnz24jx	669	19	biological	biological	JJ
cord-280549-bsnz24jx	669	20	arms	arm	NNS
cord-280549-bsnz24jx	669	21	race	race	NN
cord-280549-bsnz24jx	669	22	.	.	.
cord-280549-bsnz24jx	670	1	It	-PRON-	PRP
cord-280549-bsnz24jx	670	2	is	be	VBZ
cord-280549-bsnz24jx	670	3	clear	clear	JJ
cord-280549-bsnz24jx	670	4	that	that	IN
cord-280549-bsnz24jx	670	5	viruses	virus	NNS
cord-280549-bsnz24jx	670	6	could	could	MD
cord-280549-bsnz24jx	670	7	utilize	utilize	VB
cord-280549-bsnz24jx	670	8	different	different	JJ
cord-280549-bsnz24jx	670	9	nodes	node	NNS
cord-280549-bsnz24jx	670	10	of	of	IN
cord-280549-bsnz24jx	670	11	the	the	DT
cord-280549-bsnz24jx	670	12	cell	cell	NN
cord-280549-bsnz24jx	670	13	cycle	cycle	NN
cord-280549-bsnz24jx	670	14	machinery	machinery	NN
cord-280549-bsnz24jx	670	15	to	to	TO
cord-280549-bsnz24jx	670	16	hamper	hamper	VB
cord-280549-bsnz24jx	670	17	cell	cell	NN
cord-280549-bsnz24jx	670	18	division	division	NN
cord-280549-bsnz24jx	670	19	to	to	TO
cord-280549-bsnz24jx	670	20	escape	escape	VB
cord-280549-bsnz24jx	670	21	the	the	DT
cord-280549-bsnz24jx	670	22	dependency	dependency	NN
cord-280549-bsnz24jx	670	23	on	on	IN
cord-280549-bsnz24jx	670	24	the	the	DT
cord-280549-bsnz24jx	670	25	normal	normal	JJ
cord-280549-bsnz24jx	670	26	progression	progression	NN
cord-280549-bsnz24jx	670	27	of	of	IN
cord-280549-bsnz24jx	670	28	cellular	cellular	JJ
cord-280549-bsnz24jx	670	29	proliferation	proliferation	NN
cord-280549-bsnz24jx	670	30	.	.	.
cord-280549-bsnz24jx	671	1	The	the	DT
cord-280549-bsnz24jx	671	2	mechanistic	mechanistic	JJ
cord-280549-bsnz24jx	671	3	study	study	NN
cord-280549-bsnz24jx	671	4	of	of	IN
cord-280549-bsnz24jx	671	5	these	these	DT
cord-280549-bsnz24jx	671	6	interactions	interaction	NNS
cord-280549-bsnz24jx	671	7	has	have	VBZ
cord-280549-bsnz24jx	671	8	revealed	reveal	VBN
cord-280549-bsnz24jx	671	9	unexpected	unexpected	JJ
cord-280549-bsnz24jx	671	10	,	,	,
cord-280549-bsnz24jx	671	11	non	non	JJ
cord-280549-bsnz24jx	671	12	-	-	JJ
cord-280549-bsnz24jx	671	13	canonical	canonical	JJ
cord-280549-bsnz24jx	671	14	roles	role	NNS
cord-280549-bsnz24jx	671	15	of	of	IN
cord-280549-bsnz24jx	671	16	cellular	cellular	JJ
cord-280549-bsnz24jx	671	17	proteins	protein	NNS
cord-280549-bsnz24jx	671	18	.	.	.
cord-280549-bsnz24jx	672	1	Further	further	JJ
cord-280549-bsnz24jx	672	2	work	work	NN
cord-280549-bsnz24jx	672	3	should	should	MD
cord-280549-bsnz24jx	672	4	bring	bring	VB
cord-280549-bsnz24jx	672	5	about	about	RP
cord-280549-bsnz24jx	672	6	a	a	DT
cord-280549-bsnz24jx	672	7	more	more	RBR
cord-280549-bsnz24jx	672	8	refined	refined	JJ
cord-280549-bsnz24jx	672	9	understanding	understanding	NN
cord-280549-bsnz24jx	672	10	that	that	WDT
cord-280549-bsnz24jx	672	11	will	will	MD
cord-280549-bsnz24jx	672	12	shed	shed	VB
cord-280549-bsnz24jx	672	13	new	new	JJ
cord-280549-bsnz24jx	672	14	light	light	NN
cord-280549-bsnz24jx	672	15	on	on	IN
cord-280549-bsnz24jx	672	16	the	the	DT
cord-280549-bsnz24jx	672	17	panoply	panoply	NN
cord-280549-bsnz24jx	672	18	of	of	IN
cord-280549-bsnz24jx	672	19	assets	asset	NNS
cord-280549-bsnz24jx	672	20	available	available	JJ
cord-280549-bsnz24jx	672	21	to	to	IN
cord-280549-bsnz24jx	672	22	viruses	virus	NNS
cord-280549-bsnz24jx	672	23	to	to	TO
cord-280549-bsnz24jx	672	24	subvert	subvert	VB
cord-280549-bsnz24jx	672	25	the	the	DT
cord-280549-bsnz24jx	672	26	process	process	NN
cord-280549-bsnz24jx	672	27	of	of	IN
cord-280549-bsnz24jx	672	28	cell	cell	NN
cord-280549-bsnz24jx	672	29	division	division	NN
cord-280549-bsnz24jx	672	30	,	,	,
cord-280549-bsnz24jx	672	31	while	while	IN
cord-280549-bsnz24jx	672	32	at	at	IN
cord-280549-bsnz24jx	672	33	the	the	DT
cord-280549-bsnz24jx	672	34	same	same	JJ
cord-280549-bsnz24jx	672	35	time	time	NN
cord-280549-bsnz24jx	672	36	providing	provide	VBG
cord-280549-bsnz24jx	672	37	insight	insight	NN
cord-280549-bsnz24jx	672	38	into	into	IN
cord-280549-bsnz24jx	672	39	the	the	DT
cord-280549-bsnz24jx	672	40	function	function	NN
cord-280549-bsnz24jx	672	41	of	of	IN
cord-280549-bsnz24jx	672	42	host	host	NN
cord-280549-bsnz24jx	672	43	proteins	protein	NNS
cord-280549-bsnz24jx	672	44	that	that	WDT
cord-280549-bsnz24jx	672	45	can	can	MD
cord-280549-bsnz24jx	672	46	offer	offer	VB
cord-280549-bsnz24jx	672	47	unexpected	unexpected	JJ
cord-280549-bsnz24jx	672	48	handles	handle	NNS
cord-280549-bsnz24jx	672	49	to	to	TO
cord-280549-bsnz24jx	672	50	counteract	counteract	VB
cord-280549-bsnz24jx	672	51	viral	viral	JJ
cord-280549-bsnz24jx	672	52	infection	infection	NN
cord-280549-bsnz24jx	672	53	.	.	.
cord-280549-bsnz24jx	673	1	All	all	DT
cord-280549-bsnz24jx	673	2	authors	author	NNS
cord-280549-bsnz24jx	673	3	listed	list	VBN
cord-280549-bsnz24jx	673	4	have	have	VBP
cord-280549-bsnz24jx	673	5	made	make	VBN
cord-280549-bsnz24jx	673	6	a	a	DT
cord-280549-bsnz24jx	673	7	substantial	substantial	JJ
cord-280549-bsnz24jx	673	8	,	,	,
cord-280549-bsnz24jx	673	9	direct	direct	JJ
cord-280549-bsnz24jx	673	10	and	and	CC
cord-280549-bsnz24jx	673	11	intellectual	intellectual	JJ
cord-280549-bsnz24jx	673	12	contribution	contribution	NN
cord-280549-bsnz24jx	673	13	to	to	IN
cord-280549-bsnz24jx	673	14	the	the	DT
cord-280549-bsnz24jx	673	15	work	work	NN
cord-280549-bsnz24jx	673	16	,	,	,
cord-280549-bsnz24jx	673	17	and	and	CC
cord-280549-bsnz24jx	673	18	approved	approve	VBD
cord-280549-bsnz24jx	673	19	it	-PRON-	PRP
cord-280549-bsnz24jx	673	20	for	for	IN
cord-280549-bsnz24jx	673	21	publication	publication	NN
cord-280549-bsnz24jx	673	22	.	.	.
cord-280549-bsnz24jx	673	23	 	 	_SP
cord-280549-bsnz24jx	674	1	Threonine	Threonine	NNP
cord-280549-bsnz24jx	674	2	68	68	CD
cord-280549-bsnz24jx	674	3	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	674	4	by	by	IN
cord-280549-bsnz24jx	674	5	ataxia	ataxia	NN
cord-280549-bsnz24jx	674	6	telangiectasia	telangiectasia	NNP
cord-280549-bsnz24jx	674	7	mutated	mutate	VBN
cord-280549-bsnz24jx	674	8	is	be	VBZ
cord-280549-bsnz24jx	674	9	required	require	VBN
cord-280549-bsnz24jx	674	10	for	for	IN
cord-280549-bsnz24jx	674	11	efficient	efficient	JJ
cord-280549-bsnz24jx	674	12	activation	activation	NN
cord-280549-bsnz24jx	674	13	of	of	IN
cord-280549-bsnz24jx	674	14	Chk2	Chk2	NNP
cord-280549-bsnz24jx	674	15	in	in	IN
cord-280549-bsnz24jx	674	16	response	response	NN
cord-280549-bsnz24jx	674	17	to	to	IN
cord-280549-bsnz24jx	674	18	ionizing	ionize	VBG
cord-280549-bsnz24jx	674	19	radiation	radiation	NN
cord-280549-bsnz24jx	674	20	Primary	primary	JJ
cord-280549-bsnz24jx	674	21	structure	structure	NN
cord-280549-bsnz24jx	674	22	of	of	IN
cord-280549-bsnz24jx	674	23	the	the	DT
cord-280549-bsnz24jx	674	24	Herpesvirus	Herpesvirus	NNP
cord-280549-bsnz24jx	674	25	ateles	atele	NNS
cord-280549-bsnz24jx	674	26	genome	genome	NN
cord-280549-bsnz24jx	674	27	Cdc2-cyclin	cdc2-cyclin	NN
cord-280549-bsnz24jx	674	28	E	e	NN
cord-280549-bsnz24jx	674	29	complexes	complex	NNS
cord-280549-bsnz24jx	674	30	regulate	regulate	VBP
cord-280549-bsnz24jx	674	31	the	the	DT
cord-280549-bsnz24jx	674	32	G1	G1	NNP
cord-280549-bsnz24jx	674	33	/	/	SYM
cord-280549-bsnz24jx	674	34	S	S	NNP
cord-280549-bsnz24jx	674	35	phase	phase	NN
cord-280549-bsnz24jx	674	36	transition	transition	NN
cord-280549-bsnz24jx	675	1	Chromatin	Chromatin	NNP
cord-280549-bsnz24jx	675	2	decondensation	decondensation	NN
cord-280549-bsnz24jx	675	3	in	in	IN
cord-280549-bsnz24jx	675	4	Sphase	Sphase	NNP
cord-280549-bsnz24jx	675	5	involves	involve	VBZ
cord-280549-bsnz24jx	675	6	recruitment	recruitment	NN
cord-280549-bsnz24jx	675	7	of	of	IN
cord-280549-bsnz24jx	675	8	Cdk2	Cdk2	NNP
cord-280549-bsnz24jx	675	9	by	by	IN
cord-280549-bsnz24jx	675	10	Cdc45	Cdc45	NNP
cord-280549-bsnz24jx	675	11	and	and	CC
cord-280549-bsnz24jx	675	12	histone	histone	NN
cord-280549-bsnz24jx	675	13	H1	h1	NN
cord-280549-bsnz24jx	675	14	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	675	15	Involvement	Involvement	NNP
cord-280549-bsnz24jx	675	16	of	of	IN
cord-280549-bsnz24jx	675	17	the	the	DT
cord-280549-bsnz24jx	675	18	interaction	interaction	NN
cord-280549-bsnz24jx	675	19	between	between	IN
cord-280549-bsnz24jx	675	20	p21	p21	NN
cord-280549-bsnz24jx	675	21	and	and	CC
cord-280549-bsnz24jx	675	22	proliferating	proliferate	VBG
cord-280549-bsnz24jx	675	23	cell	cell	NN
cord-280549-bsnz24jx	675	24	nuclear	nuclear	JJ
cord-280549-bsnz24jx	675	25	antigen	antigen	NN
cord-280549-bsnz24jx	675	26	for	for	IN
cord-280549-bsnz24jx	675	27	the	the	DT
cord-280549-bsnz24jx	675	28	maintenance	maintenance	NN
cord-280549-bsnz24jx	675	29	of	of	IN
cord-280549-bsnz24jx	675	30	G2	G2	NNP
cord-280549-bsnz24jx	675	31	/	/	SYM
cord-280549-bsnz24jx	675	32	M	M	NNP
cord-280549-bsnz24jx	675	33	arrest	arrest	NN
cord-280549-bsnz24jx	675	34	after	after	IN
cord-280549-bsnz24jx	675	35	DNA	dna	NN
cord-280549-bsnz24jx	675	36	damage	damage	NN
cord-280549-bsnz24jx	675	37	Notch	notch	NN
cord-280549-bsnz24jx	675	38	signaling	signaling	NN
cord-280549-bsnz24jx	675	39	:	:	:
cord-280549-bsnz24jx	675	40	cell	cell	NN
cord-280549-bsnz24jx	675	41	fate	fate	NN
cord-280549-bsnz24jx	675	42	control	control	NN
cord-280549-bsnz24jx	675	43	and	and	CC
cord-280549-bsnz24jx	675	44	signal	signal	NN
cord-280549-bsnz24jx	675	45	integration	integration	NN
cord-280549-bsnz24jx	675	46	in	in	IN
cord-280549-bsnz24jx	675	47	development	development	NN
cord-280549-bsnz24jx	675	48	Induction	Induction	NNP
cord-280549-bsnz24jx	675	49	of	of	IN
cord-280549-bsnz24jx	675	50	DNA	dna	NN
cord-280549-bsnz24jx	675	51	damage	damage	NN
cord-280549-bsnz24jx	675	52	signaling	signaling	NN
cord-280549-bsnz24jx	675	53	upon	upon	IN
cord-280549-bsnz24jx	675	54	Rift	Rift	NNP
cord-280549-bsnz24jx	675	55	Valley	Valley	NNP
cord-280549-bsnz24jx	675	56	fever	fever	NN
cord-280549-bsnz24jx	675	57	virus	virus	NN
cord-280549-bsnz24jx	675	58	infection	infection	NN
cord-280549-bsnz24jx	675	59	results	result	VBZ
cord-280549-bsnz24jx	675	60	in	in	IN
cord-280549-bsnz24jx	675	61	cell	cell	NN
cord-280549-bsnz24jx	675	62	cycle	cycle	NN
cord-280549-bsnz24jx	675	63	arrest	arrest	NN
cord-280549-bsnz24jx	675	64	and	and	CC
cord-280549-bsnz24jx	675	65	increased	increase	VBN
cord-280549-bsnz24jx	675	66	viral	viral	JJ
cord-280549-bsnz24jx	675	67	replication	replication	NN
cord-280549-bsnz24jx	676	1	Adenovirus	Adenovirus	NNP
cord-280549-bsnz24jx	676	2	E1A	e1a	NN
cord-280549-bsnz24jx	676	3	proteins	protein	NNS
cord-280549-bsnz24jx	676	4	can	can	MD
cord-280549-bsnz24jx	676	5	dissociate	dissociate	VB
cord-280549-bsnz24jx	676	6	heteromeric	heteromeric	JJ
cord-280549-bsnz24jx	676	7	complexes	complex	NNS
cord-280549-bsnz24jx	676	8	involving	involve	VBG
cord-280549-bsnz24jx	676	9	the	the	DT
cord-280549-bsnz24jx	676	10	E2F	E2F	NNP
cord-280549-bsnz24jx	676	11	transcription	transcription	NN
cord-280549-bsnz24jx	676	12	factor	factor	NN
cord-280549-bsnz24jx	676	13	:	:	:
cord-280549-bsnz24jx	676	14	a	a	DT
cord-280549-bsnz24jx	676	15	novel	novel	JJ
cord-280549-bsnz24jx	676	16	mechanism	mechanism	NN
cord-280549-bsnz24jx	676	17	for	for	IN
cord-280549-bsnz24jx	676	18	E1A	e1a	JJ
cord-280549-bsnz24jx	676	19	trans	trans	JJ
cord-280549-bsnz24jx	676	20	-	-	NN
cord-280549-bsnz24jx	676	21	activation	activation	NN
cord-280549-bsnz24jx	676	22	Cyclin	Cyclin	NNP
cord-280549-bsnz24jx	676	23	D1	d1	NN
cord-280549-bsnz24jx	676	24	is	be	VBZ
cord-280549-bsnz24jx	676	25	a	a	DT
cord-280549-bsnz24jx	676	26	nuclear	nuclear	JJ
cord-280549-bsnz24jx	676	27	protein	protein	NN
cord-280549-bsnz24jx	676	28	required	require	VBN
cord-280549-bsnz24jx	676	29	for	for	IN
cord-280549-bsnz24jx	676	30	cell	cell	NN
cord-280549-bsnz24jx	676	31	cycle	cycle	NN
cord-280549-bsnz24jx	676	32	progression	progression	NN
cord-280549-bsnz24jx	676	33	in	in	IN
cord-280549-bsnz24jx	677	1	G1	G1	NNP
cord-280549-bsnz24jx	677	2	Human	Human	NNP
cord-280549-bsnz24jx	677	3	papillomavirus	papillomavirus	NN
cord-280549-bsnz24jx	677	4	(	(	-LRB-
cord-280549-bsnz24jx	677	5	HPV	HPV	NNP
cord-280549-bsnz24jx	677	6	)	)	-RRB-
cord-280549-bsnz24jx	677	7	E7	E7	NNP
cord-280549-bsnz24jx	677	8	induces	induce	VBZ
cord-280549-bsnz24jx	677	9	prolonged	prolong	VBD
cord-280549-bsnz24jx	677	10	G2	G2	NNP
cord-280549-bsnz24jx	677	11	following	follow	VBG
cord-280549-bsnz24jx	677	12	S	s	NN
cord-280549-bsnz24jx	677	13	phase	phase	NN
cord-280549-bsnz24jx	677	14	reentry	reentry	NN
cord-280549-bsnz24jx	677	15	in	in	IN
cord-280549-bsnz24jx	677	16	differentiated	differentiated	JJ
cord-280549-bsnz24jx	677	17	human	human	JJ
cord-280549-bsnz24jx	677	18	keratinocytes	keratinocyte	NNS
cord-280549-bsnz24jx	678	1	The	the	DT
cord-280549-bsnz24jx	678	2	region	region	NN
cord-280549-bsnz24jx	678	3	of	of	IN
cord-280549-bsnz24jx	678	4	the	the	DT
cord-280549-bsnz24jx	678	5	HPV	HPV	NNP
cord-280549-bsnz24jx	678	6	E7	E7	NNP
cord-280549-bsnz24jx	678	7	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	678	8	homologous	homologous	JJ
cord-280549-bsnz24jx	678	9	to	to	IN
cord-280549-bsnz24jx	678	10	adenovirus	adenovirus	NN
cord-280549-bsnz24jx	678	11	E1a	E1a	NNS
cord-280549-bsnz24jx	678	12	and	and	CC
cord-280549-bsnz24jx	679	1	Sv40	Sv40	NNP
cord-280549-bsnz24jx	680	1	large	large	JJ
cord-280549-bsnz24jx	680	2	T	T	NNP
cord-280549-bsnz24jx	680	3	antigen	antigen	NN
cord-280549-bsnz24jx	680	4	contains	contain	VBZ
cord-280549-bsnz24jx	680	5	separate	separate	JJ
cord-280549-bsnz24jx	680	6	domains	domain	NNS
cord-280549-bsnz24jx	680	7	for	for	IN
cord-280549-bsnz24jx	680	8	Rb	rb	NN
cord-280549-bsnz24jx	680	9	binding	binding	NN
cord-280549-bsnz24jx	680	10	and	and	CC
cord-280549-bsnz24jx	680	11	casein	casein	NN
cord-280549-bsnz24jx	680	12	kinase	kinase	NN
cord-280549-bsnz24jx	680	13	II	ii	CD
cord-280549-bsnz24jx	680	14	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	681	1	The	the	DT
cord-280549-bsnz24jx	681	2	retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	681	3	protein	protein	NN
cord-280549-bsnz24jx	681	4	pathway	pathway	NN
cord-280549-bsnz24jx	681	5	and	and	CC
cord-280549-bsnz24jx	681	6	the	the	DT
cord-280549-bsnz24jx	681	7	restriction	restriction	NN
cord-280549-bsnz24jx	681	8	point	point	NN
cord-280549-bsnz24jx	681	9	Chk1	Chk1	NNP
cord-280549-bsnz24jx	681	10	and	and	CC
cord-280549-bsnz24jx	681	11	Chk2	Chk2	NNP
cord-280549-bsnz24jx	681	12	kinases	kinase	NNS
cord-280549-bsnz24jx	681	13	in	in	IN
cord-280549-bsnz24jx	681	14	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	681	15	control	control	NN
cord-280549-bsnz24jx	681	16	and	and	CC
cord-280549-bsnz24jx	681	17	cancer	cancer	NN
cord-280549-bsnz24jx	681	18	HTLV	HTLV	NNP
cord-280549-bsnz24jx	682	1	-I	-I	NNP
cord-280549-bsnz24jx	682	2	p30	p30	NNP
cord-280549-bsnz24jx	682	3	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	682	4	multiple	multiple	JJ
cord-280549-bsnz24jx	682	5	S	S	NNP
cord-280549-bsnz24jx	682	6	phase	phase	NN
cord-280549-bsnz24jx	682	7	entry	entry	NN
cord-280549-bsnz24jx	682	8	checkpoints	checkpoint	NNS
cord-280549-bsnz24jx	682	9	,	,	,
cord-280549-bsnz24jx	682	10	decreases	decrease	VBZ
cord-280549-bsnz24jx	682	11	cyclin	cyclin	NN
cord-280549-bsnz24jx	682	12	E	E	NNP
cord-280549-bsnz24jx	682	13	-	-	JJ
cord-280549-bsnz24jx	682	14	CDK2	cdk2	JJ
cord-280549-bsnz24jx	682	15	interactions	interaction	NNS
cord-280549-bsnz24jx	682	16	and	and	CC
cord-280549-bsnz24jx	682	17	delays	delay	NNS
cord-280549-bsnz24jx	682	18	cell	cell	NN
cord-280549-bsnz24jx	682	19	cycle	cycle	NN
cord-280549-bsnz24jx	682	20	progression	progression	NN
cord-280549-bsnz24jx	683	1	The	the	DT
cord-280549-bsnz24jx	683	2	structural	structural	JJ
cord-280549-bsnz24jx	683	3	protein	protein	NN
cord-280549-bsnz24jx	683	4	ODV	ODV	NNP
cord-280549-bsnz24jx	683	5	-	-	HYPH
cord-280549-bsnz24jx	683	6	EC27	EC27	NNP
cord-280549-bsnz24jx	683	7	of	of	IN
cord-280549-bsnz24jx	683	8	Autographa	Autographa	NNP
cord-280549-bsnz24jx	683	9	californica	californica	NNP
cord-280549-bsnz24jx	683	10	nucleopolyhedrovirus	nucleopolyhedrovirus	NNP
cord-280549-bsnz24jx	683	11	is	be	VBZ
cord-280549-bsnz24jx	684	1	a	a	DT
cord-280549-bsnz24jx	684	2	multifunctional	multifunctional	JJ
cord-280549-bsnz24jx	684	3	viral	viral	JJ
cord-280549-bsnz24jx	684	4	cyclin	cyclin	NN
cord-280549-bsnz24jx	684	5	Hepatitis	Hepatitis	NNP
cord-280549-bsnz24jx	684	6	B	B	NNP
cord-280549-bsnz24jx	684	7	virus	virus	NN
cord-280549-bsnz24jx	684	8	HBx	hbx	NN
cord-280549-bsnz24jx	684	9	protein	protein	NN
cord-280549-bsnz24jx	684	10	deregulates	deregulate	VBZ
cord-280549-bsnz24jx	684	11	cell	cell	NN
cord-280549-bsnz24jx	684	12	cycle	cycle	NN
cord-280549-bsnz24jx	684	13	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	684	14	controls	control	VBZ
cord-280549-bsnz24jx	684	15	G2	G2	NNP
cord-280549-bsnz24jx	684	16	/	/	SYM
cord-280549-bsnz24jx	684	17	M	M	NNP
cord-280549-bsnz24jx	684	18	cell	cell	NN
cord-280549-bsnz24jx	684	19	cycle	cycle	NN
cord-280549-bsnz24jx	684	20	arrest	arrest	NN
cord-280549-bsnz24jx	684	21	correlates	correlate	VBZ
cord-280549-bsnz24jx	684	22	with	with	IN
cord-280549-bsnz24jx	684	23	primate	primate	JJ
cord-280549-bsnz24jx	684	24	lentiviral	lentiviral	JJ
cord-280549-bsnz24jx	684	25	Vpr	Vpr	NNP
cord-280549-bsnz24jx	684	26	interaction	interaction	NN
cord-280549-bsnz24jx	684	27	with	with	IN
cord-280549-bsnz24jx	684	28	the	the	DT
cord-280549-bsnz24jx	684	29	SLX4	SLX4	NNP
cord-280549-bsnz24jx	684	30	complex	complex	NN
cord-280549-bsnz24jx	685	1	Cdk2	cdk2	JJ
cord-280549-bsnz24jx	685	2	knockout	knockout	NN
cord-280549-bsnz24jx	685	3	mice	mouse	NNS
cord-280549-bsnz24jx	685	4	are	be	VBP
cord-280549-bsnz24jx	685	5	viable	viable	JJ
cord-280549-bsnz24jx	685	6	Molecular	molecular	JJ
cord-280549-bsnz24jx	685	7	themes	theme	NNS
cord-280549-bsnz24jx	685	8	in	in	IN
cord-280549-bsnz24jx	685	9	oncogenesis	oncogenesis	NN
cord-280549-bsnz24jx	686	1	The	the	DT
cord-280549-bsnz24jx	686	2	restriction	restriction	NN
cord-280549-bsnz24jx	686	3	point	point	NN
cord-280549-bsnz24jx	686	4	of	of	IN
cord-280549-bsnz24jx	687	1	the	the	DT
cord-280549-bsnz24jx	687	2	cell	cell	NN
cord-280549-bsnz24jx	687	3	cycle	cycle	NN
cord-280549-bsnz24jx	687	4	A	a	DT
cord-280549-bsnz24jx	687	5	growth	growth	NN
cord-280549-bsnz24jx	687	6	factor	factor	NN
cord-280549-bsnz24jx	687	7	-	-	HYPH
cord-280549-bsnz24jx	687	8	dependent	dependent	JJ
cord-280549-bsnz24jx	687	9	nuclear	nuclear	JJ
cord-280549-bsnz24jx	687	10	kinase	kinase	NN
cord-280549-bsnz24jx	687	11	phosphorylates	phosphorylate	VBZ
cord-280549-bsnz24jx	687	12	p27(Kip1	p27(kip1	NN
cord-280549-bsnz24jx	687	13	)	)	-RRB-
cord-280549-bsnz24jx	687	14	and	and	CC
cord-280549-bsnz24jx	687	15	regulates	regulate	VBZ
cord-280549-bsnz24jx	687	16	cell	cell	NN
cord-280549-bsnz24jx	687	17	cycle	cycle	NN
cord-280549-bsnz24jx	687	18	progression	progression	NN
cord-280549-bsnz24jx	687	19	14	14	CD
cord-280549-bsnz24jx	687	20	-	-	SYM
cord-280549-bsnz24jx	687	21	3	3	CD
cord-280549-bsnz24jx	687	22	-	-	SYM
cord-280549-bsnz24jx	687	23	3	3	CD
cord-280549-bsnz24jx	687	24	theta	theta	NN
cord-280549-bsnz24jx	687	25	binding	binding	NN
cord-280549-bsnz24jx	687	26	to	to	IN
cord-280549-bsnz24jx	687	27	cell	cell	NN
cord-280549-bsnz24jx	687	28	cycle	cycle	NN
cord-280549-bsnz24jx	687	29	regulatory	regulatory	JJ
cord-280549-bsnz24jx	687	30	factors	factor	NNS
cord-280549-bsnz24jx	687	31	is	be	VBZ
cord-280549-bsnz24jx	687	32	enhanced	enhance	VBN
cord-280549-bsnz24jx	687	33	by	by	IN
cord-280549-bsnz24jx	687	34	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	687	35	Vpr	Vpr	NNP
cord-280549-bsnz24jx	687	36	Cul4A	cul4a	NN
cord-280549-bsnz24jx	687	37	and	and	CC
cord-280549-bsnz24jx	687	38	DDB1	DDB1	NNP
cord-280549-bsnz24jx	687	39	associate	associate	NN
cord-280549-bsnz24jx	687	40	with	with	IN
cord-280549-bsnz24jx	687	41	Skp2	Skp2	NNP
cord-280549-bsnz24jx	687	42	to	to	TO
cord-280549-bsnz24jx	687	43	target	target	VB
cord-280549-bsnz24jx	687	44	p27Kip1	p27kip1	CD
cord-280549-bsnz24jx	687	45	for	for	IN
cord-280549-bsnz24jx	687	46	proteolysis	proteolysis	NN
cord-280549-bsnz24jx	687	47	involving	involve	VBG
cord-280549-bsnz24jx	687	48	the	the	DT
cord-280549-bsnz24jx	687	49	COP9	COP9	NNP
cord-280549-bsnz24jx	687	50	signalosome	signalosome	NN
cord-280549-bsnz24jx	688	1	The	the	DT
cord-280549-bsnz24jx	688	2	herpes	herpe	NNS
cord-280549-bsnz24jx	688	3	simplex	simplex	NN
cord-280549-bsnz24jx	688	4	virus	virus	NN
cord-280549-bsnz24jx	688	5	type	type	NN
cord-280549-bsnz24jx	688	6	1	1	CD
cord-280549-bsnz24jx	688	7	(	(	-LRB-
cord-280549-bsnz24jx	688	8	HSV-1	hsv-1	NN
cord-280549-bsnz24jx	688	9	)	)	-RRB-
cord-280549-bsnz24jx	689	1	regulatory	regulatory	JJ
cord-280549-bsnz24jx	689	2	protein	protein	NN
cord-280549-bsnz24jx	689	3	ICP0	ICP0	NNP
cord-280549-bsnz24jx	689	4	interacts	interact	VBZ
cord-280549-bsnz24jx	689	5	with	with	IN
cord-280549-bsnz24jx	689	6	and	and	CC
cord-280549-bsnz24jx	690	1	Ubiquitinates	Ubiquitinates	NNP
cord-280549-bsnz24jx	690	2	p53	p53	NN
cord-280549-bsnz24jx	690	3	Herpes	Herpes	NNP
cord-280549-bsnz24jx	690	4	simplex	simplex	NN
cord-280549-bsnz24jx	690	5	virus	virus	NN
cord-280549-bsnz24jx	690	6	type	type	NN
cord-280549-bsnz24jx	690	7	1	1	CD
cord-280549-bsnz24jx	690	8	immediate	immediate	JJ
cord-280549-bsnz24jx	690	9	-	-	HYPH
cord-280549-bsnz24jx	690	10	early	early	JJ
cord-280549-bsnz24jx	690	11	protein	protein	NN
cord-280549-bsnz24jx	690	12	ICP0	ICP0	NNP
cord-280549-bsnz24jx	690	13	and	and	CC
cord-280549-bsnz24jx	690	14	is	be	VBZ
cord-280549-bsnz24jx	690	15	isolated	isolate	VBN
cord-280549-bsnz24jx	690	16	RING	ring	NN
cord-280549-bsnz24jx	690	17	finger	finger	NN
cord-280549-bsnz24jx	690	18	domain	domain	NN
cord-280549-bsnz24jx	690	19	act	act	NN
cord-280549-bsnz24jx	690	20	as	as	IN
cord-280549-bsnz24jx	690	21	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	690	22	E3	E3	NNP
cord-280549-bsnz24jx	690	23	ligases	ligase	NNS
cord-280549-bsnz24jx	690	24	in	in	IN
cord-280549-bsnz24jx	690	25	vitro	vitro	FW
cord-280549-bsnz24jx	690	26	Autographa	Autographa	NNP
cord-280549-bsnz24jx	690	27	californica	californica	NN
cord-280549-bsnz24jx	690	28	nucleopolyhedrovirus	nucleopolyhedrovirus	JJ
cord-280549-bsnz24jx	690	29	infection	infection	NN
cord-280549-bsnz24jx	690	30	results	result	VBZ
cord-280549-bsnz24jx	690	31	in	in	IN
cord-280549-bsnz24jx	690	32	Sf9	sf9	JJ
cord-280549-bsnz24jx	690	33	cell	cell	NN
cord-280549-bsnz24jx	690	34	cycle	cycle	NN
cord-280549-bsnz24jx	690	35	arrest	arrest	NN
cord-280549-bsnz24jx	690	36	at	at	IN
cord-280549-bsnz24jx	690	37	G2	G2	NNP
cord-280549-bsnz24jx	690	38	/	/	SYM
cord-280549-bsnz24jx	690	39	M	M	NNP
cord-280549-bsnz24jx	690	40	phase	phase	NN
cord-280549-bsnz24jx	690	41	Human	human	JJ
cord-280549-bsnz24jx	690	42	cytomegalovirus	cytomegalovirus	NN
cord-280549-bsnz24jx	690	43	infection	infection	NN
cord-280549-bsnz24jx	690	44	results	result	NNS
cord-280549-bsnz24jx	690	45	in	in	IN
cord-280549-bsnz24jx	690	46	altered	alter	VBN
cord-280549-bsnz24jx	690	47	Cdk2	cdk2	JJ
cord-280549-bsnz24jx	690	48	subcellular	subcellular	JJ
cord-280549-bsnz24jx	690	49	localization	localization	NN
cord-280549-bsnz24jx	691	1	The	the	DT
cord-280549-bsnz24jx	691	2	retroviral	retroviral	JJ
cord-280549-bsnz24jx	691	3	cyclin	cyclin	NN
cord-280549-bsnz24jx	691	4	of	of	IN
cord-280549-bsnz24jx	691	5	walleye	walleye	NN
cord-280549-bsnz24jx	691	6	dermal	dermal	JJ
cord-280549-bsnz24jx	691	7	sarcoma	sarcoma	NN
cord-280549-bsnz24jx	691	8	virus	virus	NN
cord-280549-bsnz24jx	691	9	binds	bind	VBZ
cord-280549-bsnz24jx	691	10	cyclin	cyclin	NN
cord-280549-bsnz24jx	691	11	-	-	HYPH
cord-280549-bsnz24jx	691	12	dependent	dependent	JJ
cord-280549-bsnz24jx	691	13	kinases	kinase	NNS
cord-280549-bsnz24jx	691	14	3	3	CD
cord-280549-bsnz24jx	691	15	and	and	CC
cord-280549-bsnz24jx	691	16	8	8	CD
cord-280549-bsnz24jx	691	17	Effects	effect	NNS
cord-280549-bsnz24jx	691	18	of	of	IN
cord-280549-bsnz24jx	691	19	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	691	20	of	of	IN
cord-280549-bsnz24jx	691	21	threonine	threonine	NN
cord-280549-bsnz24jx	691	22	160	160	CD
cord-280549-bsnz24jx	691	23	on	on	IN
cord-280549-bsnz24jx	691	24	cyclindependent	cyclindependent	NN
cord-280549-bsnz24jx	691	25	kinase	kinase	NN
cord-280549-bsnz24jx	691	26	2	2	CD
cord-280549-bsnz24jx	691	27	structure	structure	NN
cord-280549-bsnz24jx	691	28	and	and	CC
cord-280549-bsnz24jx	691	29	activity	activity	NN
cord-280549-bsnz24jx	692	1	Dual	dual	JJ
cord-280549-bsnz24jx	692	2	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	692	3	controls	control	VBZ
cord-280549-bsnz24jx	692	4	Cdc25	Cdc25	NNP
cord-280549-bsnz24jx	692	5	phosphatases	phosphatase	NNS
cord-280549-bsnz24jx	692	6	and	and	CC
cord-280549-bsnz24jx	692	7	mitotic	mitotic	JJ
cord-280549-bsnz24jx	692	8	entry	entry	NN
cord-280549-bsnz24jx	692	9	Crystal	Crystal	NNP
cord-280549-bsnz24jx	692	10	structure	structure	NN
cord-280549-bsnz24jx	692	11	of	of	IN
cord-280549-bsnz24jx	692	12	a	a	DT
cord-280549-bsnz24jx	692	13	gamma	gamma	NN
cord-280549-bsnz24jx	692	14	-	-	HYPH
cord-280549-bsnz24jx	692	15	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	692	16	cyclin	cyclin	NN
cord-280549-bsnz24jx	692	17	-	-	HYPH
cord-280549-bsnz24jx	692	18	cdk	cdk	NNP
cord-280549-bsnz24jx	692	19	complex	complex	NN
cord-280549-bsnz24jx	692	20	SKP2	SKP2	NNP
cord-280549-bsnz24jx	692	21	is	be	VBZ
cord-280549-bsnz24jx	692	22	required	require	VBN
cord-280549-bsnz24jx	692	23	for	for	IN
cord-280549-bsnz24jx	692	24	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	692	25	-	-	HYPH
cord-280549-bsnz24jx	692	26	mediated	mediate	VBN
cord-280549-bsnz24jx	692	27	degradation	degradation	NN
cord-280549-bsnz24jx	692	28	of	of	IN
cord-280549-bsnz24jx	692	29	the	the	DT
cord-280549-bsnz24jx	692	30	CDK	CDK	NNP
cord-280549-bsnz24jx	692	31	inhibitor	inhibitor	NN
cord-280549-bsnz24jx	692	32	p27	p27	NN
cord-280549-bsnz24jx	692	33	Kaposi	Kaposi	NNP
cord-280549-bsnz24jx	692	34	's	's	POS
cord-280549-bsnz24jx	692	35	sarcoma	sarcoma	NN
cord-280549-bsnz24jx	692	36	-	-	HYPH
cord-280549-bsnz24jx	692	37	associated	associate	VBN
cord-280549-bsnz24jx	692	38	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	692	39	-	-	HYPH
cord-280549-bsnz24jx	692	40	like	like	JJ
cord-280549-bsnz24jx	692	41	DNA	dna	NN
cord-280549-bsnz24jx	692	42	-	-	HYPH
cord-280549-bsnz24jx	692	43	sequences	sequence	NNS
cord-280549-bsnz24jx	692	44	in	in	IN
cord-280549-bsnz24jx	692	45	AIDSrelated	aidsrelated	JJ
cord-280549-bsnz24jx	692	46	body	body	NN
cord-280549-bsnz24jx	692	47	-	-	HYPH
cord-280549-bsnz24jx	692	48	cavity	cavity	NN
cord-280549-bsnz24jx	692	49	-	-	HYPH
cord-280549-bsnz24jx	692	50	based	base	VBN
cord-280549-bsnz24jx	692	51	lymphomas	lymphoma	NNS
cord-280549-bsnz24jx	692	52	Identification	identification	NN
cord-280549-bsnz24jx	692	53	of	of	IN
cord-280549-bsnz24jx	692	54	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	692	55	-	-	HYPH
cord-280549-bsnz24jx	692	56	like	like	JJ
cord-280549-bsnz24jx	692	57	DNA	dna	NN
cord-280549-bsnz24jx	692	58	-	-	HYPH
cord-280549-bsnz24jx	692	59	sequences	sequence	NNS
cord-280549-bsnz24jx	692	60	in	in	IN
cord-280549-bsnz24jx	692	61	AIDS	AIDS	NNP
cord-280549-bsnz24jx	692	62	-	-	HYPH
cord-280549-bsnz24jx	692	63	associated	associate	VBN
cord-280549-bsnz24jx	692	64	Kaposi's	Kaposi's	NNP
cord-280549-bsnz24jx	692	65	-	-	HYPH
cord-280549-bsnz24jx	692	66	sarcoma	sarcoma	NN
cord-280549-bsnz24jx	692	67	Cyclin	Cyclin	NNP
cord-280549-bsnz24jx	692	68	encoded	encode	VBN
cord-280549-bsnz24jx	692	69	by	by	IN
cord-280549-bsnz24jx	692	70	KS	KS	NNP
cord-280549-bsnz24jx	692	71	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	692	72	Human	human	JJ
cord-280549-bsnz24jx	692	73	oncogenic	oncogenic	JJ
cord-280549-bsnz24jx	692	74	viruses	virus	NNS
cord-280549-bsnz24jx	692	75	:	:	:
cord-280549-bsnz24jx	693	1	nature	nature	NN
cord-280549-bsnz24jx	693	2	and	and	CC
cord-280549-bsnz24jx	693	3	discovery	discovery	NN
cord-280549-bsnz24jx	693	4	Bocavirus	Bocavirus	NNP
cord-280549-bsnz24jx	693	5	infection	infection	NN
cord-280549-bsnz24jx	693	6	induces	induce	VBZ
cord-280549-bsnz24jx	693	7	mitochondrion	mitochondrion	NN
cord-280549-bsnz24jx	693	8	-	-	HYPH
cord-280549-bsnz24jx	693	9	mediated	mediate	VBN
cord-280549-bsnz24jx	693	10	apoptosis	apoptosis	NN
cord-280549-bsnz24jx	693	11	and	and	CC
cord-280549-bsnz24jx	693	12	cell	cell	NN
cord-280549-bsnz24jx	693	13	cycle	cycle	NN
cord-280549-bsnz24jx	693	14	arrest	arrest	NN
cord-280549-bsnz24jx	693	15	at	at	IN
cord-280549-bsnz24jx	693	16	G(2)/M	G(2)/M	NNP
cord-280549-bsnz24jx	693	17	phase	phase	NN
cord-280549-bsnz24jx	694	1	The	the	DT
cord-280549-bsnz24jx	694	2	influenza	influenza	NN
cord-280549-bsnz24jx	694	3	virus	virus	NN
cord-280549-bsnz24jx	694	4	M2	m2	NN
cord-280549-bsnz24jx	694	5	protein	protein	NN
cord-280549-bsnz24jx	694	6	cytoplasmic	cytoplasmic	JJ
cord-280549-bsnz24jx	694	7	tail	tail	NN
cord-280549-bsnz24jx	694	8	interacts	interact	VBZ
cord-280549-bsnz24jx	694	9	with	with	IN
cord-280549-bsnz24jx	694	10	the	the	DT
cord-280549-bsnz24jx	694	11	M1	M1	NNP
cord-280549-bsnz24jx	694	12	protein	protein	NN
cord-280549-bsnz24jx	694	13	and	and	CC
cord-280549-bsnz24jx	694	14	influences	influence	VBZ
cord-280549-bsnz24jx	694	15	virus	virus	NN
cord-280549-bsnz24jx	694	16	assembly	assembly	NN
cord-280549-bsnz24jx	694	17	at	at	IN
cord-280549-bsnz24jx	694	18	the	the	DT
cord-280549-bsnz24jx	694	19	site	site	NN
cord-280549-bsnz24jx	694	20	of	of	IN
cord-280549-bsnz24jx	694	21	virus	virus	NN
cord-280549-bsnz24jx	694	22	budding	bud	VBG
cord-280549-bsnz24jx	694	23	Identification	identification	NN
cord-280549-bsnz24jx	694	24	of	of	IN
cord-280549-bsnz24jx	694	25	a	a	DT
cord-280549-bsnz24jx	694	26	region	region	NN
cord-280549-bsnz24jx	694	27	of	of	IN
cord-280549-bsnz24jx	694	28	simian	simian	JJ
cord-280549-bsnz24jx	694	29	virus	virus	NN
cord-280549-bsnz24jx	694	30	40	40	CD
cord-280549-bsnz24jx	694	31	large	large	JJ
cord-280549-bsnz24jx	694	32	T	t	NN
cord-280549-bsnz24jx	694	33	antigen	antigen	NN
cord-280549-bsnz24jx	694	34	required	require	VBN
cord-280549-bsnz24jx	694	35	for	for	IN
cord-280549-bsnz24jx	694	36	cell	cell	NN
cord-280549-bsnz24jx	694	37	transformation	transformation	NN
cord-280549-bsnz24jx	694	38	Degradation	degradation	NN
cord-280549-bsnz24jx	694	39	of	of	IN
cord-280549-bsnz24jx	694	40	p21cip1	p21cip1	NNP
cord-280549-bsnz24jx	694	41	in	in	IN
cord-280549-bsnz24jx	694	42	cells	cell	NNS
cord-280549-bsnz24jx	694	43	productively	productively	RB
cord-280549-bsnz24jx	694	44	infected	infect	VBN
cord-280549-bsnz24jx	694	45	with	with	IN
cord-280549-bsnz24jx	694	46	human	human	JJ
cord-280549-bsnz24jx	694	47	cytomegalovirus	cytomegalovirus	NN
cord-280549-bsnz24jx	694	48	Mechanistic	mechanistic	JJ
cord-280549-bsnz24jx	694	49	insights	insight	NNS
cord-280549-bsnz24jx	694	50	into	into	IN
cord-280549-bsnz24jx	694	51	avian	avian	JJ
cord-280549-bsnz24jx	694	52	reovirus	reovirus	NNP
cord-280549-bsnz24jx	694	53	p17-modulated	p17-modulated	CD
cord-280549-bsnz24jx	694	54	suppression	suppression	NN
cord-280549-bsnz24jx	694	55	of	of	IN
cord-280549-bsnz24jx	694	56	cell	cell	NN
cord-280549-bsnz24jx	694	57	-	-	HYPH
cord-280549-bsnz24jx	694	58	cycle	cycle	NN
cord-280549-bsnz24jx	694	59	CDK	CDK	NNP
cord-280549-bsnz24jx	694	60	/	/	SYM
cord-280549-bsnz24jx	694	61	cyclin	cyclin	NN
cord-280549-bsnz24jx	694	62	complexes	complex	NNS
cord-280549-bsnz24jx	694	63	and	and	CC
cord-280549-bsnz24jx	694	64	enhancement	enhancement	NN
cord-280549-bsnz24jx	694	65	of	of	IN
cord-280549-bsnz24jx	694	66	p53	p53	NN
cord-280549-bsnz24jx	694	67	and	and	CC
cord-280549-bsnz24jx	694	68	cyclin	cyclin	NN
cord-280549-bsnz24jx	694	69	H	h	NN
cord-280549-bsnz24jx	694	70	interaction	interaction	NN
cord-280549-bsnz24jx	694	71	Suppression	suppression	NN
cord-280549-bsnz24jx	694	72	of	of	IN
cord-280549-bsnz24jx	694	73	vimentin	vimentin	NN
cord-280549-bsnz24jx	694	74	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	694	75	by	by	IN
cord-280549-bsnz24jx	694	76	the	the	DT
cord-280549-bsnz24jx	694	77	avian	avian	JJ
cord-280549-bsnz24jx	694	78	reovirus	reovirus	NNP
cord-280549-bsnz24jx	694	79	p17	p17	NN
cord-280549-bsnz24jx	694	80	through	through	IN
cord-280549-bsnz24jx	694	81	inhibition	inhibition	NN
cord-280549-bsnz24jx	694	82	of	of	IN
cord-280549-bsnz24jx	694	83	CDK1	CDK1	NNP
cord-280549-bsnz24jx	694	84	and	and	CC
cord-280549-bsnz24jx	694	85	Plk1	Plk1	NNP
cord-280549-bsnz24jx	694	86	impacting	impact	VBG
cord-280549-bsnz24jx	694	87	the	the	DT
cord-280549-bsnz24jx	694	88	G2	G2	NNP
cord-280549-bsnz24jx	694	89	/	/	SYM
cord-280549-bsnz24jx	694	90	M	M	NNP
cord-280549-bsnz24jx	694	91	phase	phase	NN
cord-280549-bsnz24jx	694	92	of	of	IN
cord-280549-bsnz24jx	694	93	the	the	DT
cord-280549-bsnz24jx	694	94	cell	cell	NN
cord-280549-bsnz24jx	694	95	cycle	cycle	NN
cord-280549-bsnz24jx	695	1	The	the	DT
cord-280549-bsnz24jx	695	2	ATM	ATM	NNS
cord-280549-bsnz24jx	695	3	/	/	SYM
cord-280549-bsnz24jx	695	4	ATR	ATR	NNP
cord-280549-bsnz24jx	695	5	signaling	signal	VBG
cord-280549-bsnz24jx	695	6	effector	effector	NN
cord-280549-bsnz24jx	696	1	Chk2	Chk2	NNP
cord-280549-bsnz24jx	696	2	is	be	VBZ
cord-280549-bsnz24jx	696	3	targeted	target	VBN
cord-280549-bsnz24jx	696	4	by	by	IN
cord-280549-bsnz24jx	696	5	Epstein	Epstein	NNP
cord-280549-bsnz24jx	696	6	-	-	HYPH
cord-280549-bsnz24jx	696	7	Barr	Barr	NNP
cord-280549-bsnz24jx	696	8	virus	virus	NN
cord-280549-bsnz24jx	696	9	nuclear	nuclear	JJ
cord-280549-bsnz24jx	696	10	antigen	antigen	NNP
cord-280549-bsnz24jx	696	11	3C	3C	NNP
cord-280549-bsnz24jx	696	12	to	to	TO
cord-280549-bsnz24jx	696	13	release	release	VB
cord-280549-bsnz24jx	696	14	the	the	DT
cord-280549-bsnz24jx	696	15	G(2)/M	G(2)/M	NNP
cord-280549-bsnz24jx	696	16	cell	cell	NN
cord-280549-bsnz24jx	696	17	cycle	cycle	NN
cord-280549-bsnz24jx	696	18	block	block	NN
cord-280549-bsnz24jx	696	19	Loss	loss	NN
cord-280549-bsnz24jx	696	20	of	of	IN
cord-280549-bsnz24jx	696	21	G(1)/S	G(1)/S	NNP
cord-280549-bsnz24jx	696	22	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	696	23	in	in	IN
cord-280549-bsnz24jx	696	24	human	human	JJ
cord-280549-bsnz24jx	696	25	immunodeficiency	immunodeficiency	NN
cord-280549-bsnz24jx	696	26	virus	virus	NN
cord-280549-bsnz24jx	696	27	type	type	NN
cord-280549-bsnz24jx	696	28	1-infected	1-infected	CD
cord-280549-bsnz24jx	696	29	cells	cell	NNS
cord-280549-bsnz24jx	697	1	is	be	VBZ
cord-280549-bsnz24jx	697	2	associated	associate	VBN
cord-280549-bsnz24jx	697	3	with	with	IN
cord-280549-bsnz24jx	697	4	a	a	DT
cord-280549-bsnz24jx	697	5	lack	lack	NN
cord-280549-bsnz24jx	697	6	of	of	IN
cord-280549-bsnz24jx	697	7	cyclin	cyclin	NN
cord-280549-bsnz24jx	697	8	-	-	HYPH
cord-280549-bsnz24jx	697	9	dependent	dependent	JJ
cord-280549-bsnz24jx	697	10	kinase	kinase	NN
cord-280549-bsnz24jx	697	11	inhibitor	inhibitor	NN
cord-280549-bsnz24jx	697	12	p21	p21	NN
cord-280549-bsnz24jx	697	13	/	/	SYM
cord-280549-bsnz24jx	697	14	Waf1	Waf1	NNP
cord-280549-bsnz24jx	697	15	Function	Function	NNP
cord-280549-bsnz24jx	697	16	and	and	CC
cord-280549-bsnz24jx	697	17	regulation	regulation	NN
cord-280549-bsnz24jx	697	18	of	of	IN
cord-280549-bsnz24jx	697	19	the	the	DT
cord-280549-bsnz24jx	697	20	Mediator	Mediator	NNP
cord-280549-bsnz24jx	697	21	complex	complex	JJ
cord-280549-bsnz24jx	697	22	ATR	ATR	NNP
cord-280549-bsnz24jx	697	23	and	and	CC
cord-280549-bsnz24jx	697	24	ATRIP	ATRIP	NNP
cord-280549-bsnz24jx	697	25	:	:	:
cord-280549-bsnz24jx	698	1	partners	partner	NNS
cord-280549-bsnz24jx	698	2	in	in	IN
cord-280549-bsnz24jx	698	3	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	698	4	signaling	signal	VBG
cord-280549-bsnz24jx	698	5	Zika	Zika	NNP
cord-280549-bsnz24jx	698	6	virus	virus	NN
cord-280549-bsnz24jx	698	7	depletes	deplete	VBZ
cord-280549-bsnz24jx	698	8	neural	neural	JJ
cord-280549-bsnz24jx	698	9	progenitors	progenitor	NNS
cord-280549-bsnz24jx	698	10	in	in	IN
cord-280549-bsnz24jx	698	11	human	human	JJ
cord-280549-bsnz24jx	698	12	cerebral	cerebral	JJ
cord-280549-bsnz24jx	698	13	organoids	organoid	NNS
cord-280549-bsnz24jx	698	14	through	through	IN
cord-280549-bsnz24jx	698	15	activation	activation	NN
cord-280549-bsnz24jx	698	16	of	of	IN
cord-280549-bsnz24jx	698	17	the	the	DT
cord-280549-bsnz24jx	698	18	innate	innate	JJ
cord-280549-bsnz24jx	698	19	immune	immune	JJ
cord-280549-bsnz24jx	698	20	receptor	receptor	NN
cord-280549-bsnz24jx	698	21	TLR3	TLR3	NNP
cord-280549-bsnz24jx	698	22	Association	Association	NNP
cord-280549-bsnz24jx	698	23	between	between	IN
cord-280549-bsnz24jx	698	24	microcephaly	microcephaly	NNS
cord-280549-bsnz24jx	698	25	,	,	,
cord-280549-bsnz24jx	698	26	Zika	Zika	NNP
cord-280549-bsnz24jx	698	27	virus	virus	NN
cord-280549-bsnz24jx	698	28	infection	infection	NN
cord-280549-bsnz24jx	698	29	,	,	,
cord-280549-bsnz24jx	698	30	and	and	CC
cord-280549-bsnz24jx	698	31	other	other	JJ
cord-280549-bsnz24jx	698	32	risk	risk	NN
cord-280549-bsnz24jx	698	33	factors	factor	NNS
cord-280549-bsnz24jx	698	34	in	in	IN
cord-280549-bsnz24jx	698	35	Brazil	Brazil	NNP
cord-280549-bsnz24jx	698	36	:	:	:
cord-280549-bsnz24jx	698	37	final	final	JJ
cord-280549-bsnz24jx	698	38	report	report	NN
cord-280549-bsnz24jx	698	39	of	of	IN
cord-280549-bsnz24jx	698	40	a	a	DT
cord-280549-bsnz24jx	698	41	case	case	NN
cord-280549-bsnz24jx	698	42	-	-	HYPH
cord-280549-bsnz24jx	698	43	control	control	NN
cord-280549-bsnz24jx	698	44	study	study	NN
cord-280549-bsnz24jx	698	45	Dynamic	dynamic	JJ
cord-280549-bsnz24jx	698	46	disruptions	disruption	NNS
cord-280549-bsnz24jx	698	47	in	in	IN
cord-280549-bsnz24jx	698	48	nuclear	nuclear	JJ
cord-280549-bsnz24jx	698	49	envelope	envelope	NN
cord-280549-bsnz24jx	698	50	architecture	architecture	NN
cord-280549-bsnz24jx	698	51	and	and	CC
cord-280549-bsnz24jx	698	52	integrity	integrity	NN
cord-280549-bsnz24jx	698	53	induced	induce	VBN
cord-280549-bsnz24jx	698	54	by	by	IN
cord-280549-bsnz24jx	698	55	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	698	56	Vpr	Vpr	NNP
cord-280549-bsnz24jx	698	57	SV40	SV40	NNP
cord-280549-bsnz24jx	698	58	large	large	JJ
cord-280549-bsnz24jx	698	59	tumor	tumor	NN
cord-280549-bsnz24jx	698	60	antigen	antigen	NN
cord-280549-bsnz24jx	698	61	forms	form	VBZ
cord-280549-bsnz24jx	698	62	a	a	DT
cord-280549-bsnz24jx	698	63	specific	specific	JJ
cord-280549-bsnz24jx	698	64	complex	complex	NN
cord-280549-bsnz24jx	698	65	with	with	IN
cord-280549-bsnz24jx	698	66	the	the	DT
cord-280549-bsnz24jx	698	67	product	product	NN
cord-280549-bsnz24jx	698	68	of	of	IN
cord-280549-bsnz24jx	698	69	the	the	DT
cord-280549-bsnz24jx	698	70	retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	698	71	susceptibility	susceptibility	NN
cord-280549-bsnz24jx	698	72	gene	gene	NN
cord-280549-bsnz24jx	698	73	NS3	NS3	VBD
cord-280549-bsnz24jx	698	74	protein	protein	NN
cord-280549-bsnz24jx	698	75	of	of	IN
cord-280549-bsnz24jx	698	76	Hepatitis	Hepatitis	NNP
cord-280549-bsnz24jx	698	77	C	C	NNP
cord-280549-bsnz24jx	698	78	virus	virus	NN
cord-280549-bsnz24jx	698	79	associates	associate	NNS
cord-280549-bsnz24jx	698	80	with	with	IN
cord-280549-bsnz24jx	698	81	the	the	DT
cord-280549-bsnz24jx	698	82	tumour	tumour	NN
cord-280549-bsnz24jx	698	83	suppressor	suppressor	NN
cord-280549-bsnz24jx	698	84	p53	p53	NN
cord-280549-bsnz24jx	698	85	and	and	CC
cord-280549-bsnz24jx	698	86	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	698	87	its	-PRON-	PRP$
cord-280549-bsnz24jx	698	88	function	function	NN
cord-280549-bsnz24jx	698	89	in	in	IN
cord-280549-bsnz24jx	698	90	an	an	DT
cord-280549-bsnz24jx	698	91	NS3	ns3	RB
cord-280549-bsnz24jx	698	92	sequence	sequence	NN
cord-280549-bsnz24jx	698	93	-	-	HYPH
cord-280549-bsnz24jx	698	94	dependent	dependent	JJ
cord-280549-bsnz24jx	698	95	manner	manner	NN
cord-280549-bsnz24jx	698	96	Activation	activation	NN
cord-280549-bsnz24jx	698	97	of	of	IN
cord-280549-bsnz24jx	698	98	human	human	JJ
cord-280549-bsnz24jx	698	99	cyclindependent	cyclindependent	NN
cord-280549-bsnz24jx	698	100	kinases	kinase	NNS
cord-280549-bsnz24jx	698	101	in	in	IN
cord-280549-bsnz24jx	698	102	vitro	vitro	FW
cord-280549-bsnz24jx	698	103	MAT1	MAT1	NNP
cord-280549-bsnz24jx	698	104	(	(	-LRB-
cord-280549-bsnz24jx	698	105	'	'	``
cord-280549-bsnz24jx	698	106	menage	menage	NN
cord-280549-bsnz24jx	698	107	a	a	DT
cord-280549-bsnz24jx	698	108	trois	trois	FW
cord-280549-bsnz24jx	698	109	'	'	''
cord-280549-bsnz24jx	698	110	)	)	-RRB-
cord-280549-bsnz24jx	699	1	a	a	DT
cord-280549-bsnz24jx	699	2	new	new	JJ
cord-280549-bsnz24jx	699	3	RING	ring	NN
cord-280549-bsnz24jx	699	4	finger	finger	NN
cord-280549-bsnz24jx	699	5	protein	protein	NN
cord-280549-bsnz24jx	699	6	subunit	subunit	NN
cord-280549-bsnz24jx	699	7	stabilizing	stabilize	VBG
cord-280549-bsnz24jx	699	8	cyclin	cyclin	NN
cord-280549-bsnz24jx	699	9	H	H	NNP
cord-280549-bsnz24jx	699	10	-	-	HYPH
cord-280549-bsnz24jx	699	11	cdk7	cdk7	NN
cord-280549-bsnz24jx	699	12	complexes	complex	NNS
cord-280549-bsnz24jx	699	13	in	in	IN
cord-280549-bsnz24jx	699	14	starfish	starfish	NN
cord-280549-bsnz24jx	699	15	and	and	CC
cord-280549-bsnz24jx	699	16	Xenopus	Xenopus	NNP
cord-280549-bsnz24jx	700	1	,	,	,
cord-280549-bsnz24jx	700	2	CAK	CAK	NNP
cord-280549-bsnz24jx	700	3	Glycogen	Glycogen	NNP
cord-280549-bsnz24jx	700	4	synthase	synthase	NN
cord-280549-bsnz24jx	700	5	kinase-3beta	kinase-3beta	NN
cord-280549-bsnz24jx	700	6	regulates	regulate	VBZ
cord-280549-bsnz24jx	700	7	cyclin	cyclin	NN
cord-280549-bsnz24jx	700	8	D1	d1	NN
cord-280549-bsnz24jx	700	9	proteolysis	proteolysis	NN
cord-280549-bsnz24jx	700	10	and	and	CC
cord-280549-bsnz24jx	700	11	subcellular	subcellular	JJ
cord-280549-bsnz24jx	700	12	localization	localization	NN
cord-280549-bsnz24jx	700	13	Cell	cell	NN
cord-280549-bsnz24jx	700	14	cycle	cycle	NN
cord-280549-bsnz24jx	700	15	perturbations	perturbation	NNS
cord-280549-bsnz24jx	700	16	induced	induce	VBN
cord-280549-bsnz24jx	700	17	by	by	IN
cord-280549-bsnz24jx	700	18	infection	infection	NN
cord-280549-bsnz24jx	700	19	with	with	IN
cord-280549-bsnz24jx	700	20	the	the	DT
cord-280549-bsnz24jx	700	21	coronavirus	coronavirus	NN
cord-280549-bsnz24jx	700	22	infectious	infectious	JJ
cord-280549-bsnz24jx	700	23	bronchitis	bronchitis	NN
cord-280549-bsnz24jx	700	24	virus	virus	NN
cord-280549-bsnz24jx	700	25	and	and	CC
cord-280549-bsnz24jx	700	26	their	-PRON-	PRP$
cord-280549-bsnz24jx	700	27	effect	effect	NN
cord-280549-bsnz24jx	700	28	on	on	IN
cord-280549-bsnz24jx	700	29	virus	virus	NN
cord-280549-bsnz24jx	700	30	replication	replication	NN
cord-280549-bsnz24jx	700	31	Measles	Measles	NNP
cord-280549-bsnz24jx	700	32	virus	virus	NN
cord-280549-bsnz24jx	700	33	exploits	exploit	VBZ
cord-280549-bsnz24jx	700	34	dendritic	dendritic	JJ
cord-280549-bsnz24jx	700	35	cells	cell	NNS
cord-280549-bsnz24jx	700	36	to	to	TO
cord-280549-bsnz24jx	700	37	suppress	suppress	VB
cord-280549-bsnz24jx	700	38	CD4(+	cd4(+	CD
cord-280549-bsnz24jx	700	39	)	)	-RRB-
cord-280549-bsnz24jx	701	1	T	t	NN
cord-280549-bsnz24jx	701	2	-	-	HYPH
cord-280549-bsnz24jx	701	3	cell	cell	NN
cord-280549-bsnz24jx	701	4	proliferation	proliferation	NN
cord-280549-bsnz24jx	701	5	via	via	IN
cord-280549-bsnz24jx	701	6	expression	expression	NN
cord-280549-bsnz24jx	701	7	of	of	IN
cord-280549-bsnz24jx	701	8	surface	surface	NN
cord-280549-bsnz24jx	701	9	viral	viral	JJ
cord-280549-bsnz24jx	701	10	glycoproteins	glycoprotein	NNS
cord-280549-bsnz24jx	701	11	independently	independently	RB
cord-280549-bsnz24jx	701	12	of	of	IN
cord-280549-bsnz24jx	701	13	T	t	NN
cord-280549-bsnz24jx	701	14	-	-	HYPH
cord-280549-bsnz24jx	701	15	cell	cell	NN
cord-280549-bsnz24jx	701	16	transinfection	transinfection	NN
cord-280549-bsnz24jx	701	17	HTLV-1	HTLV-1	NNP
cord-280549-bsnz24jx	701	18	Tax	Tax	NNP
cord-280549-bsnz24jx	701	19	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	701	20	subverts	subvert	VBZ
cord-280549-bsnz24jx	701	21	the	the	DT
cord-280549-bsnz24jx	701	22	cellular	cellular	JJ
cord-280549-bsnz24jx	701	23	DNA	dna	NN
cord-280549-bsnz24jx	701	24	damage	damage	NN
cord-280549-bsnz24jx	701	25	response	response	NN
cord-280549-bsnz24jx	701	26	via	via	IN
cord-280549-bsnz24jx	701	27	binding	bind	VBG
cord-280549-bsnz24jx	701	28	to	to	IN
cord-280549-bsnz24jx	701	29	DNA	dna	NN
cord-280549-bsnz24jx	701	30	-	-	HYPH
cord-280549-bsnz24jx	701	31	dependent	dependent	JJ
cord-280549-bsnz24jx	701	32	protein	protein	NN
cord-280549-bsnz24jx	701	33	kinase	kinase	NN
cord-280549-bsnz24jx	702	1	The	the	DT
cord-280549-bsnz24jx	702	2	human	human	JJ
cord-280549-bsnz24jx	702	3	papilloma	papilloma	NN
cord-280549-bsnz24jx	702	4	virus-16	virus-16	NNP
cord-280549-bsnz24jx	702	5	E7	E7	NNP
cord-280549-bsnz24jx	702	6	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	702	7	is	be	VBZ
cord-280549-bsnz24jx	702	8	able	able	JJ
cord-280549-bsnz24jx	702	9	to	to	TO
cord-280549-bsnz24jx	702	10	bind	bind	VB
cord-280549-bsnz24jx	702	11	to	to	IN
cord-280549-bsnz24jx	702	12	the	the	DT
cord-280549-bsnz24jx	702	13	retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	702	14	gene	gene	NN
cord-280549-bsnz24jx	702	15	product	product	NN
cord-280549-bsnz24jx	702	16	WAF1	WAF1	NNP
cord-280549-bsnz24jx	702	17	,	,	,
cord-280549-bsnz24jx	702	18	a	a	DT
cord-280549-bsnz24jx	702	19	potential	potential	JJ
cord-280549-bsnz24jx	702	20	mediator	mediator	NN
cord-280549-bsnz24jx	702	21	of	of	IN
cord-280549-bsnz24jx	702	22	p53	p53	NN
cord-280549-bsnz24jx	702	23	tumor	tumor	NN
cord-280549-bsnz24jx	702	24	suppression	suppression	NN
cord-280549-bsnz24jx	702	25	Specific	specific	JJ
cord-280549-bsnz24jx	702	26	destruction	destruction	NN
cord-280549-bsnz24jx	702	27	of	of	IN
cord-280549-bsnz24jx	702	28	kinetochore	kinetochore	NN
cord-280549-bsnz24jx	702	29	protein	protein	NN
cord-280549-bsnz24jx	702	30	CENP	CENP	NNP
cord-280549-bsnz24jx	702	31	-	-	HYPH
cord-280549-bsnz24jx	702	32	C	C	NNP
cord-280549-bsnz24jx	702	33	and	and	CC
cord-280549-bsnz24jx	702	34	disruption	disruption	NN
cord-280549-bsnz24jx	702	35	of	of	IN
cord-280549-bsnz24jx	702	36	cell	cell	NN
cord-280549-bsnz24jx	702	37	division	division	NN
cord-280549-bsnz24jx	702	38	by	by	IN
cord-280549-bsnz24jx	702	39	herpes	herpes	NNP
cord-280549-bsnz24jx	702	40	simplex	simplex	NNP
cord-280549-bsnz24jx	702	41	virus	virus	NN
cord-280549-bsnz24jx	703	1	immediate	immediate	JJ
cord-280549-bsnz24jx	703	2	-	-	HYPH
cord-280549-bsnz24jx	703	3	early	early	JJ
cord-280549-bsnz24jx	703	4	protein	protein	NN
cord-280549-bsnz24jx	703	5	Vmw110	vmw110	NN
cord-280549-bsnz24jx	703	6	Functional	functional	JJ
cord-280549-bsnz24jx	703	7	interactions	interaction	NNS
cord-280549-bsnz24jx	703	8	of	of	IN
cord-280549-bsnz24jx	703	9	the	the	DT
cord-280549-bsnz24jx	703	10	retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	703	11	protein	protein	NN
cord-280549-bsnz24jx	703	12	with	with	IN
cord-280549-bsnz24jx	703	13	mammalian	mammalian	JJ
cord-280549-bsnz24jx	703	14	D	d	NN
cord-280549-bsnz24jx	703	15	-	-	HYPH
cord-280549-bsnz24jx	703	16	type	type	NN
cord-280549-bsnz24jx	703	17	cyclins	cyclin	NNS
cord-280549-bsnz24jx	703	18	Zika	Zika	NNP
cord-280549-bsnz24jx	703	19	virus	virus	NN
cord-280549-bsnz24jx	703	20	-	-	HYPH
cord-280549-bsnz24jx	703	21	induced	induce	VBN
cord-280549-bsnz24jx	703	22	microcephaly	microcephaly	NNS
cord-280549-bsnz24jx	703	23	and	and	CC
cord-280549-bsnz24jx	703	24	its	-PRON-	PRP$
cord-280549-bsnz24jx	703	25	possible	possible	JJ
cord-280549-bsnz24jx	703	26	molecular	molecular	JJ
cord-280549-bsnz24jx	703	27	mechanism	mechanism	NN
cord-280549-bsnz24jx	703	28	Cell	cell	NN
cord-280549-bsnz24jx	703	29	cycle	cycle	NN
cord-280549-bsnz24jx	703	30	-	-	HYPH
cord-280549-bsnz24jx	703	31	independent	independent	JJ
cord-280549-bsnz24jx	703	32	role	role	NN
cord-280549-bsnz24jx	703	33	of	of	IN
cord-280549-bsnz24jx	703	34	cyclin	cyclin	NN
cord-280549-bsnz24jx	703	35	D3	D3	NNP
cord-280549-bsnz24jx	703	36	in	in	IN
cord-280549-bsnz24jx	703	37	host	host	NN
cord-280549-bsnz24jx	703	38	restriction	restriction	NN
cord-280549-bsnz24jx	703	39	of	of	IN
cord-280549-bsnz24jx	703	40	influenza	influenza	NN
cord-280549-bsnz24jx	703	41	virus	virus	NN
cord-280549-bsnz24jx	703	42	infection	infection	NN
cord-280549-bsnz24jx	703	43	Human	Human	NNP
cord-280549-bsnz24jx	703	44	SLX4	SLX4	NNP
cord-280549-bsnz24jx	703	45	is	be	VBZ
cord-280549-bsnz24jx	703	46	a	a	DT
cord-280549-bsnz24jx	703	47	Holliday	Holliday	NNP
cord-280549-bsnz24jx	703	48	junction	junction	NN
cord-280549-bsnz24jx	703	49	resolvase	resolvase	NN
cord-280549-bsnz24jx	703	50	subunit	subunit	NN
cord-280549-bsnz24jx	703	51	that	that	WDT
cord-280549-bsnz24jx	703	52	binds	bind	VBZ
cord-280549-bsnz24jx	703	53	multiple	multiple	JJ
cord-280549-bsnz24jx	703	54	DNA	dna	NN
cord-280549-bsnz24jx	703	55	repair	repair	NN
cord-280549-bsnz24jx	703	56	/	/	SYM
cord-280549-bsnz24jx	703	57	recombination	recombination	NN
cord-280549-bsnz24jx	703	58	endonucleases	endonuclease	NNS
cord-280549-bsnz24jx	704	1	Herpesvirus	Herpesvirus	NNP
cord-280549-bsnz24jx	704	2	saimiri	saimiri	NNP
cord-280549-bsnz24jx	705	1	A	a	DT
cord-280549-bsnz24jx	705	2	novel	novel	JJ
cord-280549-bsnz24jx	705	3	cyclin	cyclin	NN
cord-280549-bsnz24jx	705	4	associates	associate	NNS
cord-280549-bsnz24jx	705	5	with	with	IN
cord-280549-bsnz24jx	705	6	MO15	MO15	NNP
cord-280549-bsnz24jx	705	7	/	/	SYM
cord-280549-bsnz24jx	705	8	CDK7	CDK7	NNP
cord-280549-bsnz24jx	705	9	to	to	TO
cord-280549-bsnz24jx	705	10	form	form	VB
cord-280549-bsnz24jx	705	11	the	the	DT
cord-280549-bsnz24jx	705	12	CDK	CDK	NNP
cord-280549-bsnz24jx	705	13	-	-	HYPH
cord-280549-bsnz24jx	705	14	activating	activate	VBG
cord-280549-bsnz24jx	705	15	kinase	kinase	NN
cord-280549-bsnz24jx	705	16	p53	p53	NN
cord-280549-bsnz24jx	705	17	and	and	CC
cord-280549-bsnz24jx	705	18	RPA	RPA	NNP
cord-280549-bsnz24jx	705	19	are	be	VBP
cord-280549-bsnz24jx	705	20	sequestered	sequester	VBN
cord-280549-bsnz24jx	705	21	in	in	IN
cord-280549-bsnz24jx	705	22	viral	viral	JJ
cord-280549-bsnz24jx	705	23	replication	replication	NN
cord-280549-bsnz24jx	705	24	centers	center	NNS
cord-280549-bsnz24jx	705	25	in	in	IN
cord-280549-bsnz24jx	705	26	the	the	DT
cord-280549-bsnz24jx	705	27	nuclei	nucleus	NNS
cord-280549-bsnz24jx	705	28	of	of	IN
cord-280549-bsnz24jx	705	29	cells	cell	NNS
cord-280549-bsnz24jx	705	30	infected	infect	VBN
cord-280549-bsnz24jx	705	31	with	with	IN
cord-280549-bsnz24jx	705	32	human	human	JJ
cord-280549-bsnz24jx	705	33	cytomegalovirus	cytomegalovirus	NNP
cord-280549-bsnz24jx	705	34	14	14	CD
cord-280549-bsnz24jx	705	35	-	-	SYM
cord-280549-bsnz24jx	705	36	3	3	CD
cord-280549-bsnz24jx	705	37	-	-	SYM
cord-280549-bsnz24jx	705	38	3	3	CD
cord-280549-bsnz24jx	705	39	proteins	protein	NNS
cord-280549-bsnz24jx	705	40	:	:	:
cord-280549-bsnz24jx	705	41	structure	structure	NN
cord-280549-bsnz24jx	705	42	,	,	,
cord-280549-bsnz24jx	705	43	function	function	NN
cord-280549-bsnz24jx	705	44	,	,	,
cord-280549-bsnz24jx	705	45	and	and	CC
cord-280549-bsnz24jx	705	46	regulation	regulation	NN
cord-280549-bsnz24jx	706	1	Inhibition	inhibition	NN
cord-280549-bsnz24jx	706	2	of	of	IN
cord-280549-bsnz24jx	706	3	CDK	CDK	NNP
cord-280549-bsnz24jx	706	4	activity	activity	NN
cord-280549-bsnz24jx	706	5	and	and	CC
cord-280549-bsnz24jx	706	6	PCNA	pcna	NN
cord-280549-bsnz24jx	706	7	-	-	HYPH
cord-280549-bsnz24jx	706	8	dependent	dependent	JJ
cord-280549-bsnz24jx	706	9	DNA	dna	NN
cord-280549-bsnz24jx	706	10	replication	replication	NN
cord-280549-bsnz24jx	706	11	by	by	IN
cord-280549-bsnz24jx	706	12	p21	p21	NN
cord-280549-bsnz24jx	706	13	is	be	VBZ
cord-280549-bsnz24jx	706	14	blocked	block	VBN
cord-280549-bsnz24jx	706	15	by	by	IN
cord-280549-bsnz24jx	706	16	interaction	interaction	NN
cord-280549-bsnz24jx	706	17	with	with	IN
cord-280549-bsnz24jx	706	18	the	the	DT
cord-280549-bsnz24jx	706	19	HPV-16	HPV-16	NNP
cord-280549-bsnz24jx	706	20	E7	E7	NNP
cord-280549-bsnz24jx	706	21	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	707	1	A	a	DT
cord-280549-bsnz24jx	707	2	kinase	kinase	NN
cord-280549-bsnz24jx	707	3	subunit	subunit	NN
cord-280549-bsnz24jx	707	4	of	of	IN
cord-280549-bsnz24jx	707	5	the	the	DT
cord-280549-bsnz24jx	707	6	human	human	JJ
cord-280549-bsnz24jx	707	7	mediator	mediator	NN
cord-280549-bsnz24jx	707	8	complex	complex	NN
cord-280549-bsnz24jx	707	9	,	,	,
cord-280549-bsnz24jx	707	10	CDK8	CDK8	NNP
cord-280549-bsnz24jx	707	11	,	,	,
cord-280549-bsnz24jx	707	12	positively	positively	RB
cord-280549-bsnz24jx	707	13	regulates	regulate	VBZ
cord-280549-bsnz24jx	707	14	transcriptional	transcriptional	JJ
cord-280549-bsnz24jx	707	15	activation	activation	NN
cord-280549-bsnz24jx	708	1	Recent	recent	JJ
cord-280549-bsnz24jx	708	2	Zika	Zika	NNP
cord-280549-bsnz24jx	708	3	virus	virus	NN
cord-280549-bsnz24jx	708	4	isolates	isolate	NNS
cord-280549-bsnz24jx	708	5	induce	induce	VBP
cord-280549-bsnz24jx	708	6	premature	premature	JJ
cord-280549-bsnz24jx	708	7	differentiation	differentiation	NN
cord-280549-bsnz24jx	708	8	of	of	IN
cord-280549-bsnz24jx	708	9	neural	neural	JJ
cord-280549-bsnz24jx	708	10	progenitors	progenitor	NNS
cord-280549-bsnz24jx	708	11	in	in	IN
cord-280549-bsnz24jx	708	12	human	human	JJ
cord-280549-bsnz24jx	708	13	brain	brain	NN
cord-280549-bsnz24jx	708	14	organoids	organoid	VBZ
cord-280549-bsnz24jx	708	15	Cyclin	Cyclin	NNP
cord-280549-bsnz24jx	708	16	E	E	NNP
cord-280549-bsnz24jx	708	17	ablation	ablation	NN
cord-280549-bsnz24jx	708	18	in	in	IN
cord-280549-bsnz24jx	708	19	the	the	DT
cord-280549-bsnz24jx	708	20	mouse	mouse	NN
cord-280549-bsnz24jx	708	21	ZIKA	ZIKA	NNP
cord-280549-bsnz24jx	708	22	virus	virus	NN
cord-280549-bsnz24jx	708	23	elicits	elicit	VBZ
cord-280549-bsnz24jx	708	24	P53	P53	NNP
cord-280549-bsnz24jx	708	25	activation	activation	NN
cord-280549-bsnz24jx	708	26	and	and	CC
cord-280549-bsnz24jx	708	27	genotoxic	genotoxic	JJ
cord-280549-bsnz24jx	708	28	stress	stress	NN
cord-280549-bsnz24jx	708	29	in	in	IN
cord-280549-bsnz24jx	708	30	human	human	JJ
cord-280549-bsnz24jx	708	31	neural	neural	JJ
cord-280549-bsnz24jx	708	32	progenitors	progenitor	NNS
cord-280549-bsnz24jx	708	33	similar	similar	JJ
cord-280549-bsnz24jx	708	34	to	to	IN
cord-280549-bsnz24jx	708	35	mutations	mutation	NNS
cord-280549-bsnz24jx	708	36	involved	involve	VBN
cord-280549-bsnz24jx	708	37	in	in	IN
cord-280549-bsnz24jx	708	38	severe	severe	JJ
cord-280549-bsnz24jx	708	39	forms	form	NNS
cord-280549-bsnz24jx	708	40	of	of	IN
cord-280549-bsnz24jx	708	41	genetic	genetic	JJ
cord-280549-bsnz24jx	708	42	microcephaly	microcephaly	NNS
cord-280549-bsnz24jx	708	43	Animal	animal	JJ
cord-280549-bsnz24jx	708	44	cell	cell	NN
cord-280549-bsnz24jx	708	45	cytokinesis	cytokinesis	NN
cord-280549-bsnz24jx	709	1	The	the	DT
cord-280549-bsnz24jx	709	2	cyclin	cyclin	NN
cord-280549-bsnz24jx	709	3	encoded	encode	VBN
cord-280549-bsnz24jx	709	4	by	by	IN
cord-280549-bsnz24jx	709	5	Kaposi	Kaposi	NNP
cord-280549-bsnz24jx	709	6	's	's	POS
cord-280549-bsnz24jx	709	7	sarcoma	sarcoma	NN
cord-280549-bsnz24jx	709	8	-	-	HYPH
cord-280549-bsnz24jx	709	9	associated	associate	VBN
cord-280549-bsnz24jx	709	10	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	709	11	stimulates	stimulate	VBZ
cord-280549-bsnz24jx	709	12	cdk6	cdk6	NN
cord-280549-bsnz24jx	709	13	to	to	TO
cord-280549-bsnz24jx	709	14	phosphorylate	phosphorylate	VB
cord-280549-bsnz24jx	709	15	the	the	DT
cord-280549-bsnz24jx	709	16	retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	709	17	protein	protein	NN
cord-280549-bsnz24jx	709	18	and	and	CC
cord-280549-bsnz24jx	709	19	histone	histone	NN
cord-280549-bsnz24jx	709	20	H1	h1	NN
cord-280549-bsnz24jx	710	1	The	the	DT
cord-280549-bsnz24jx	710	2	human	human	JJ
cord-280549-bsnz24jx	710	3	immunodeficiency	immunodeficiency	NN
cord-280549-bsnz24jx	710	4	virus	virus	NN
cord-280549-bsnz24jx	710	5	Vpr	Vpr	NNP
cord-280549-bsnz24jx	710	6	protein	protein	NN
cord-280549-bsnz24jx	710	7	binds	bind	VBZ
cord-280549-bsnz24jx	710	8	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	710	9	:	:	:
cord-280549-bsnz24jx	710	10	implications	implication	NNS
cord-280549-bsnz24jx	710	11	for	for	IN
cord-280549-bsnz24jx	710	12	G2	G2	NNP
cord-280549-bsnz24jx	710	13	arrest	arrest	NN
cord-280549-bsnz24jx	710	14	Kinetochores	Kinetochores	NNP
cord-280549-bsnz24jx	710	15	,	,	,
cord-280549-bsnz24jx	710	16	microtubules	microtubule	NNS
cord-280549-bsnz24jx	710	17	and	and	CC
cord-280549-bsnz24jx	710	18	the	the	DT
cord-280549-bsnz24jx	710	19	metaphase	metaphase	NN
cord-280549-bsnz24jx	710	20	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	711	1	A	a	DT
cord-280549-bsnz24jx	711	2	human	human	JJ
cord-280549-bsnz24jx	711	3	herpesvirus	herpesvirus	NNP
cord-280549-bsnz24jx	711	4	microRNA	microRNA	NNP
cord-280549-bsnz24jx	711	5	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	711	6	p21	p21	NN
cord-280549-bsnz24jx	711	7	expression	expression	NN
cord-280549-bsnz24jx	711	8	and	and	CC
cord-280549-bsnz24jx	711	9	attenuates	attenuate	VBZ
cord-280549-bsnz24jx	711	10	p21-mediated	p21-mediated	JJ
cord-280549-bsnz24jx	711	11	cell	cell	NN
cord-280549-bsnz24jx	711	12	cycle	cycle	NN
cord-280549-bsnz24jx	711	13	arrest	arrest	NN
cord-280549-bsnz24jx	711	14	Phosphorylation	Phosphorylation	NNP
cord-280549-bsnz24jx	711	15	at	at	IN
cord-280549-bsnz24jx	711	16	Thr167	thr167	EX
cord-280549-bsnz24jx	711	17	is	be	VBZ
cord-280549-bsnz24jx	711	18	required	require	VBN
cord-280549-bsnz24jx	711	19	for	for	IN
cord-280549-bsnz24jx	711	20	Schizosaccharomyces	Schizosaccharomyces	NNP
cord-280549-bsnz24jx	711	21	pombe	pombe	NNP
cord-280549-bsnz24jx	712	1	p34cdc2	p34cdc2	DT
cord-280549-bsnz24jx	712	2	function	function	NN
cord-280549-bsnz24jx	712	3	Localization	localization	NN
cord-280549-bsnz24jx	712	4	of	of	IN
cord-280549-bsnz24jx	712	5	human	human	NN
cord-280549-bsnz24jx	712	6	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	712	7	is	be	VBZ
cord-280549-bsnz24jx	712	8	regulated	regulate	VBN
cord-280549-bsnz24jx	712	9	both	both	CC
cord-280549-bsnz24jx	712	10	by	by	IN
cord-280549-bsnz24jx	712	11	nuclear	nuclear	JJ
cord-280549-bsnz24jx	712	12	export	export	NN
cord-280549-bsnz24jx	712	13	and	and	CC
cord-280549-bsnz24jx	712	14	14	14	CD
cord-280549-bsnz24jx	712	15	-	-	SYM
cord-280549-bsnz24jx	712	16	3	3	CD
cord-280549-bsnz24jx	712	17	-	-	SYM
cord-280549-bsnz24jx	712	18	3	3	CD
cord-280549-bsnz24jx	712	19	protein	protein	NN
cord-280549-bsnz24jx	712	20	binding	bind	VBG
cord-280549-bsnz24jx	712	21	Measles	Measles	NNP
cord-280549-bsnz24jx	712	22	virus	virus	NN
cord-280549-bsnz24jx	712	23	-	-	HYPH
cord-280549-bsnz24jx	712	24	induced	induce	VBN
cord-280549-bsnz24jx	712	25	suppression	suppression	NN
cord-280549-bsnz24jx	712	26	of	of	IN
cord-280549-bsnz24jx	712	27	immune	immune	JJ
cord-280549-bsnz24jx	712	28	responses	response	NNS
cord-280549-bsnz24jx	712	29	Cell	Cell	NNP
cord-280549-bsnz24jx	712	30	cycle	cycle	NN
cord-280549-bsnz24jx	712	31	regulation	regulation	NN
cord-280549-bsnz24jx	712	32	of	of	IN
cord-280549-bsnz24jx	712	33	CDK2	CDK2	NNP
cord-280549-bsnz24jx	712	34	activity	activity	NN
cord-280549-bsnz24jx	712	35	by	by	IN
cord-280549-bsnz24jx	712	36	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	712	37	of	of	IN
cord-280549-bsnz24jx	712	38	Thr160	thr160	CD
cord-280549-bsnz24jx	712	39	and	and	CC
cord-280549-bsnz24jx	713	1	Tyr15	Tyr15	NNP
cord-280549-bsnz24jx	713	2	Epstein	Epstein	NNP
cord-280549-bsnz24jx	713	3	-	-	HYPH
cord-280549-bsnz24jx	713	4	Barr	Barr	NNP
cord-280549-bsnz24jx	713	5	virus	virus	NN
cord-280549-bsnz24jx	713	6	infection	infection	NN
cord-280549-bsnz24jx	713	7	is	be	VBZ
cord-280549-bsnz24jx	713	8	associated	associate	VBN
cord-280549-bsnz24jx	713	9	with	with	IN
cord-280549-bsnz24jx	713	10	p53	p53	NN
cord-280549-bsnz24jx	713	11	accumulation	accumulation	NN
cord-280549-bsnz24jx	713	12	in	in	IN
cord-280549-bsnz24jx	713	13	nasopharyngeal	nasopharyngeal	JJ
cord-280549-bsnz24jx	713	14	carcinoma	carcinoma	NN
cord-280549-bsnz24jx	713	15	Epstein	Epstein	NNP
cord-280549-bsnz24jx	713	16	-	-	HYPH
cord-280549-bsnz24jx	713	17	Barr	Barr	NNP
cord-280549-bsnz24jx	713	18	virus	virus	NN
cord-280549-bsnz24jx	714	1	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	714	2	LMP1	LMP1	NNP
cord-280549-bsnz24jx	714	3	mediates	mediate	VBZ
cord-280549-bsnz24jx	714	4	survivin	survivin	NN
cord-280549-bsnz24jx	714	5	upregulation	upregulation	NN
cord-280549-bsnz24jx	714	6	by	by	IN
cord-280549-bsnz24jx	714	7	p53	p53	NN
cord-280549-bsnz24jx	714	8	contributing	contribute	VBG
cord-280549-bsnz24jx	714	9	to	to	IN
cord-280549-bsnz24jx	714	10	G1	G1	NNP
cord-280549-bsnz24jx	714	11	/	/	SYM
cord-280549-bsnz24jx	714	12	S	S	NNP
cord-280549-bsnz24jx	714	13	cell	cell	NN
cord-280549-bsnz24jx	714	14	cycle	cycle	NN
cord-280549-bsnz24jx	714	15	progression	progression	NN
cord-280549-bsnz24jx	714	16	in	in	IN
cord-280549-bsnz24jx	714	17	nasopharyngeal	nasopharyngeal	JJ
cord-280549-bsnz24jx	714	18	carcinoma	carcinoma	NN
cord-280549-bsnz24jx	714	19	Human	Human	NNP
cord-280549-bsnz24jx	714	20	T	t	NN
cord-280549-bsnz24jx	714	21	-	-	HYPH
cord-280549-bsnz24jx	714	22	cell	cell	NN
cord-280549-bsnz24jx	714	23	leukemia	leukemia	NN
cord-280549-bsnz24jx	714	24	virus	virus	NN
cord-280549-bsnz24jx	714	25	type	type	NN
cord-280549-bsnz24jx	714	26	1	1	CD
cord-280549-bsnz24jx	714	27	Tax	Tax	NNP
cord-280549-bsnz24jx	714	28	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	714	29	prevents	prevent	VBZ
cord-280549-bsnz24jx	714	30	DNA	dna	NN
cord-280549-bsnz24jx	714	31	damage	damage	NN
cord-280549-bsnz24jx	714	32	-	-	HYPH
cord-280549-bsnz24jx	714	33	induced	induce	VBN
cord-280549-bsnz24jx	714	34	chromatin	chromatin	NN
cord-280549-bsnz24jx	714	35	egress	egress	NN
cord-280549-bsnz24jx	714	36	of	of	IN
cord-280549-bsnz24jx	714	37	hyperphosphorylated	hyperphosphorylated	JJ
cord-280549-bsnz24jx	714	38	Chk2	Chk2	NNP
cord-280549-bsnz24jx	714	39	Herpes	Herpes	NNP
cord-280549-bsnz24jx	714	40	simplex	simplex	NN
cord-280549-bsnz24jx	714	41	virus	virus	NN
cord-280549-bsnz24jx	714	42	1-infected	1-infected	CD
cord-280549-bsnz24jx	714	43	cell	cell	NN
cord-280549-bsnz24jx	714	44	protein	protein	NN
cord-280549-bsnz24jx	714	45	0	0	CD
cord-280549-bsnz24jx	715	1	contains	contain	VBZ
cord-280549-bsnz24jx	715	2	two	two	CD
cord-280549-bsnz24jx	715	3	E3	e3	NN
cord-280549-bsnz24jx	715	4	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	715	5	ligase	ligase	NN
cord-280549-bsnz24jx	715	6	sites	site	NNS
cord-280549-bsnz24jx	715	7	specific	specific	JJ
cord-280549-bsnz24jx	715	8	for	for	IN
cord-280549-bsnz24jx	715	9	different	different	JJ
cord-280549-bsnz24jx	715	10	E2	E2	NNP
cord-280549-bsnz24jx	715	11	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	715	12	-	-	HYPH
cord-280549-bsnz24jx	715	13	conjugating	conjugate	VBG
cord-280549-bsnz24jx	715	14	enzymes	enzyme	NNS
cord-280549-bsnz24jx	715	15	Physical	physical	JJ
cord-280549-bsnz24jx	715	16	interaction	interaction	NN
cord-280549-bsnz24jx	715	17	of	of	IN
cord-280549-bsnz24jx	715	18	human	human	JJ
cord-280549-bsnz24jx	715	19	T	t	NN
cord-280549-bsnz24jx	715	20	-	-	HYPH
cord-280549-bsnz24jx	715	21	cell	cell	NN
cord-280549-bsnz24jx	715	22	leukemia	leukemia	NN
cord-280549-bsnz24jx	715	23	virus	virus	NN
cord-280549-bsnz24jx	715	24	type	type	NN
cord-280549-bsnz24jx	715	25	1	1	CD
cord-280549-bsnz24jx	715	26	Tax	tax	NN
cord-280549-bsnz24jx	715	27	with	with	IN
cord-280549-bsnz24jx	715	28	cyclin	cyclin	NN
cord-280549-bsnz24jx	715	29	-	-	HYPH
cord-280549-bsnz24jx	715	30	dependent	dependent	JJ
cord-280549-bsnz24jx	715	31	kinase	kinase	NN
cord-280549-bsnz24jx	715	32	4	4	CD
cord-280549-bsnz24jx	716	1	stimulates	stimulate	VBZ
cord-280549-bsnz24jx	716	2	the	the	DT
cord-280549-bsnz24jx	716	3	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	716	4	of	of	IN
cord-280549-bsnz24jx	716	5	retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	716	6	protein	protein	NN
cord-280549-bsnz24jx	716	7	Human	Human	NNP
cord-280549-bsnz24jx	716	8	T	T	NNP
cord-280549-bsnz24jx	716	9	-	-	HYPH
cord-280549-bsnz24jx	716	10	cell	cell	NN
cord-280549-bsnz24jx	716	11	leukemia	leukemia	NN
cord-280549-bsnz24jx	716	12	virus	virus	NN
cord-280549-bsnz24jx	717	1	-I	-I	NFP
cord-280549-bsnz24jx	717	2	tax	tax	NN
cord-280549-bsnz24jx	717	3	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	717	4	functionally	functionally	RB
cord-280549-bsnz24jx	717	5	targets	target	VBZ
cord-280549-bsnz24jx	717	6	a	a	DT
cord-280549-bsnz24jx	717	7	subnuclear	subnuclear	JJ
cord-280549-bsnz24jx	717	8	complex	complex	NN
cord-280549-bsnz24jx	717	9	involved	involve	VBN
cord-280549-bsnz24jx	717	10	in	in	IN
cord-280549-bsnz24jx	717	11	cellular	cellular	JJ
cord-280549-bsnz24jx	717	12	DNA	dna	NN
cord-280549-bsnz24jx	717	13	damage	damage	NN
cord-280549-bsnz24jx	717	14	-	-	HYPH
cord-280549-bsnz24jx	717	15	response	response	NN
cord-280549-bsnz24jx	717	16	Checkpoints	checkpoint	NNS
cord-280549-bsnz24jx	717	17	:	:	:
cord-280549-bsnz24jx	717	18	controls	control	NNS
cord-280549-bsnz24jx	717	19	that	that	WDT
cord-280549-bsnz24jx	717	20	ensure	ensure	VBP
cord-280549-bsnz24jx	717	21	the	the	DT
cord-280549-bsnz24jx	717	22	order	order	NN
cord-280549-bsnz24jx	717	23	of	of	IN
cord-280549-bsnz24jx	717	24	cell	cell	NN
cord-280549-bsnz24jx	717	25	cycle	cycle	NN
cord-280549-bsnz24jx	717	26	events	event	NNS
cord-280549-bsnz24jx	717	27	Influenza	Influenza	NNP
cord-280549-bsnz24jx	717	28	A	a	DT
cord-280549-bsnz24jx	717	29	virus	virus	NN
cord-280549-bsnz24jx	717	30	replication	replication	NN
cord-280549-bsnz24jx	717	31	induces	induce	VBZ
cord-280549-bsnz24jx	717	32	cell	cell	NN
cord-280549-bsnz24jx	717	33	cycle	cycle	NN
cord-280549-bsnz24jx	717	34	arrest	arrest	NN
cord-280549-bsnz24jx	717	35	in	in	IN
cord-280549-bsnz24jx	717	36	G(0)/G(1	G(0)/G(1	NNP
cord-280549-bsnz24jx	717	37	)	)	-RRB-
cord-280549-bsnz24jx	718	1	phase	phase	NN
cord-280549-bsnz24jx	719	1	DNA	dna	NN
cord-280549-bsnz24jx	719	2	damage	damage	NN
cord-280549-bsnz24jx	719	3	-	-	HYPH
cord-280549-bsnz24jx	719	4	induced	induce	VBN
cord-280549-bsnz24jx	719	5	activation	activation	NN
cord-280549-bsnz24jx	719	6	of	of	IN
cord-280549-bsnz24jx	719	7	p53	p53	NN
cord-280549-bsnz24jx	719	8	by	by	IN
cord-280549-bsnz24jx	719	9	the	the	DT
cord-280549-bsnz24jx	719	10	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	719	11	kinase	kinase	NN
cord-280549-bsnz24jx	719	12	Chk2	Chk2	NNP
cord-280549-bsnz24jx	719	13	Perturbation	perturbation	NN
cord-280549-bsnz24jx	719	14	of	of	IN
cord-280549-bsnz24jx	719	15	cell	cell	NN
cord-280549-bsnz24jx	719	16	cycle	cycle	NN
cord-280549-bsnz24jx	719	17	progression	progression	NN
cord-280549-bsnz24jx	719	18	and	and	CC
cord-280549-bsnz24jx	719	19	cellular	cellular	JJ
cord-280549-bsnz24jx	719	20	gene	gene	NN
cord-280549-bsnz24jx	719	21	expression	expression	NN
cord-280549-bsnz24jx	719	22	as	as	IN
cord-280549-bsnz24jx	719	23	a	a	DT
cord-280549-bsnz24jx	719	24	function	function	NN
cord-280549-bsnz24jx	719	25	of	of	IN
cord-280549-bsnz24jx	719	26	herpes	herpes	NN
cord-280549-bsnz24jx	719	27	simplex	simplex	NNP
cord-280549-bsnz24jx	719	28	virus	virus	NN
cord-280549-bsnz24jx	719	29	ICP0	ICP0	NNP
cord-280549-bsnz24jx	719	30	Pregnancy	Pregnancy	NNP
cord-280549-bsnz24jx	719	31	outcomes	outcome	NNS
cord-280549-bsnz24jx	719	32	after	after	IN
cord-280549-bsnz24jx	719	33	ZIKV	ZIKV	NNP
cord-280549-bsnz24jx	719	34	infection	infection	NN
cord-280549-bsnz24jx	719	35	in	in	IN
cord-280549-bsnz24jx	719	36	French	French	NNP
cord-280549-bsnz24jx	719	37	Territories	Territories	NNPS
cord-280549-bsnz24jx	719	38	in	in	IN
cord-280549-bsnz24jx	719	39	the	the	DT
cord-280549-bsnz24jx	719	40	Americas	Americas	NNP
cord-280549-bsnz24jx	719	41	Transcriptional	Transcriptional	NNP
cord-280549-bsnz24jx	719	42	repression	repression	NN
cord-280549-bsnz24jx	719	43	of	of	IN
cord-280549-bsnz24jx	719	44	the	the	DT
cord-280549-bsnz24jx	719	45	anti	anti	JJ
cord-280549-bsnz24jx	719	46	-	-	JJ
cord-280549-bsnz24jx	719	47	apoptotic	apoptotic	JJ
cord-280549-bsnz24jx	719	48	survivin	survivin	NN
cord-280549-bsnz24jx	719	49	gene	gene	NN
cord-280549-bsnz24jx	719	50	by	by	IN
cord-280549-bsnz24jx	719	51	wild	wild	JJ
cord-280549-bsnz24jx	719	52	type	type	NN
cord-280549-bsnz24jx	719	53	p53	p53	NN
cord-280549-bsnz24jx	719	54	E2F	e2f	RB
cord-280549-bsnz24jx	719	55	-	-	HYPH
cord-280549-bsnz24jx	719	56	dependent	dependent	JJ
cord-280549-bsnz24jx	719	57	accumulation	accumulation	NN
cord-280549-bsnz24jx	719	58	of	of	IN
cord-280549-bsnz24jx	719	59	hEmi1	hEmi1	NNP
cord-280549-bsnz24jx	719	60	regulates	regulate	VBZ
cord-280549-bsnz24jx	719	61	S	S	NNP
cord-280549-bsnz24jx	719	62	phase	phase	NN
cord-280549-bsnz24jx	719	63	entry	entry	NN
cord-280549-bsnz24jx	719	64	by	by	IN
cord-280549-bsnz24jx	719	65	inhibiting	inhibit	VBG
cord-280549-bsnz24jx	719	66	APC(Cdh1	apc(cdh1	NN
cord-280549-bsnz24jx	719	67	)	)	-RRB-
cord-280549-bsnz24jx	720	1	Protein	protein	NN
cord-280549-bsnz24jx	720	2	domains	domain	NNS
cord-280549-bsnz24jx	720	3	governing	govern	VBG
cord-280549-bsnz24jx	720	4	interactions	interaction	NNS
cord-280549-bsnz24jx	720	5	between	between	IN
cord-280549-bsnz24jx	720	6	E2F	e2f	NN
cord-280549-bsnz24jx	720	7	,	,	,
cord-280549-bsnz24jx	720	8	the	the	DT
cord-280549-bsnz24jx	720	9	retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	720	10	gene	gene	NN
cord-280549-bsnz24jx	720	11	product	product	NN
cord-280549-bsnz24jx	720	12	,	,	,
cord-280549-bsnz24jx	720	13	and	and	CC
cord-280549-bsnz24jx	720	14	human	human	JJ
cord-280549-bsnz24jx	720	15	papillomavirus	papillomavirus	NN
cord-280549-bsnz24jx	720	16	type	type	NN
cord-280549-bsnz24jx	720	17	16	16	CD
cord-280549-bsnz24jx	720	18	E7	E7	NNP
cord-280549-bsnz24jx	720	19	protein	protein	NN
cord-280549-bsnz24jx	720	20	Avian	avian	JJ
cord-280549-bsnz24jx	720	21	reovirus	reovirus	NN
cord-280549-bsnz24jx	720	22	p17	p17	NN
cord-280549-bsnz24jx	720	23	and	and	CC
cord-280549-bsnz24jx	721	1	sigmaA	sigmaA	NNP
cord-280549-bsnz24jx	721	2	act	act	VBP
cord-280549-bsnz24jx	721	3	cooperatively	cooperatively	RB
cord-280549-bsnz24jx	721	4	to	to	TO
cord-280549-bsnz24jx	721	5	downregulate	downregulate	VB
cord-280549-bsnz24jx	721	6	Akt	Akt	NNP
cord-280549-bsnz24jx	721	7	by	by	IN
cord-280549-bsnz24jx	721	8	suppressing	suppress	VBG
cord-280549-bsnz24jx	721	9	mTORC2	mTORC2	JJS
cord-280549-bsnz24jx	721	10	and	and	CC
cord-280549-bsnz24jx	721	11	CDK2	CDK2	NNP
cord-280549-bsnz24jx	721	12	/	/	SYM
cord-280549-bsnz24jx	721	13	cyclin	cyclin	NN
cord-280549-bsnz24jx	721	14	A2	a2	NN
cord-280549-bsnz24jx	721	15	and	and	CC
cord-280549-bsnz24jx	721	16	upregulating	upregulate	VBG
cord-280549-bsnz24jx	721	17	proteasome	proteasome	VBN
cord-280549-bsnz24jx	721	18	PSMB6	PSMB6	NNP
cord-280549-bsnz24jx	721	19	Avian	Avian	NNP
cord-280549-bsnz24jx	721	20	reovirus	reovirus	NN
cord-280549-bsnz24jx	721	21	protein	protein	NN
cord-280549-bsnz24jx	721	22	p17	p17	NN
cord-280549-bsnz24jx	721	23	functions	function	NNS
cord-280549-bsnz24jx	721	24	as	as	IN
cord-280549-bsnz24jx	721	25	a	a	DT
cord-280549-bsnz24jx	721	26	nucleoporin	nucleoporin	NNP
cord-280549-bsnz24jx	722	1	Tpr	Tpr	NNP
cord-280549-bsnz24jx	722	2	suppressor	suppressor	NN
cord-280549-bsnz24jx	722	3	leading	lead	VBG
cord-280549-bsnz24jx	722	4	to	to	IN
cord-280549-bsnz24jx	722	5	activation	activation	NN
cord-280549-bsnz24jx	722	6	of	of	IN
cord-280549-bsnz24jx	722	7	p53	p53	NN
cord-280549-bsnz24jx	722	8	,	,	,
cord-280549-bsnz24jx	722	9	p21	p21	NN
cord-280549-bsnz24jx	722	10	and	and	CC
cord-280549-bsnz24jx	722	11	PTEN	PTEN	NNP
cord-280549-bsnz24jx	722	12	and	and	CC
cord-280549-bsnz24jx	722	13	inactivation	inactivation	NN
cord-280549-bsnz24jx	722	14	of	of	IN
cord-280549-bsnz24jx	722	15	PI3K	PI3K	NNP
cord-280549-bsnz24jx	722	16	/	/	SYM
cord-280549-bsnz24jx	722	17	AKT	AKT	NNP
cord-280549-bsnz24jx	722	18	/	/	SYM
cord-280549-bsnz24jx	722	19	mTOR	mTOR	NNP
cord-280549-bsnz24jx	722	20	and	and	CC
cord-280549-bsnz24jx	722	21	ERK	ERK	NNP
cord-280549-bsnz24jx	723	1	signaling	signal	VBG
cord-280549-bsnz24jx	723	2	pathways	pathway	NNS
cord-280549-bsnz24jx	724	1	Deubiquitinase	Deubiquitinase	NNP
cord-280549-bsnz24jx	724	2	USP37	USP37	NNP
cord-280549-bsnz24jx	724	3	is	be	VBZ
cord-280549-bsnz24jx	724	4	activated	activate	VBN
cord-280549-bsnz24jx	724	5	by	by	IN
cord-280549-bsnz24jx	724	6	CDK2	CDK2	NNP
cord-280549-bsnz24jx	724	7	to	to	TO
cord-280549-bsnz24jx	724	8	antagonize	antagonize	VB
cord-280549-bsnz24jx	724	9	APC(CDH1	APC(CDH1	NNP
cord-280549-bsnz24jx	724	10	)	)	-RRB-
cord-280549-bsnz24jx	724	11	and	and	CC
cord-280549-bsnz24jx	724	12	promote	promote	VB
cord-280549-bsnz24jx	724	13	S	S	NNP
cord-280549-bsnz24jx	724	14	phase	phase	NN
cord-280549-bsnz24jx	724	15	entry	entry	NN
cord-280549-bsnz24jx	724	16	Human	human	JJ
cord-280549-bsnz24jx	724	17	immunodeficiency	immunodeficiency	NN
cord-280549-bsnz24jx	724	18	virus	virus	NN
cord-280549-bsnz24jx	724	19	type	type	NN
cord-280549-bsnz24jx	724	20	1	1	CD
cord-280549-bsnz24jx	724	21	vpr	vpr	NNP
cord-280549-bsnz24jx	724	22	induces	induce	VBZ
cord-280549-bsnz24jx	724	23	cell	cell	NN
cord-280549-bsnz24jx	724	24	cycle	cycle	NN
cord-280549-bsnz24jx	724	25	G(2	G(2	.
cord-280549-bsnz24jx	724	26	)	)	-RRB-
cord-280549-bsnz24jx	724	27	arrest	arrest	NN
cord-280549-bsnz24jx	724	28	through	through	IN
cord-280549-bsnz24jx	724	29	Srk1	Srk1	NNP
cord-280549-bsnz24jx	724	30	/	/	SYM
cord-280549-bsnz24jx	724	31	MK2-mediated	mk2-mediate	VBN
cord-280549-bsnz24jx	724	32	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	724	33	of	of	IN
cord-280549-bsnz24jx	724	34	Cdc25	Cdc25	NNP
cord-280549-bsnz24jx	724	35	Phosphorylation	Phosphorylation	NNP
cord-280549-bsnz24jx	724	36	of	of	IN
cord-280549-bsnz24jx	724	37	retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	724	38	protein	protein	NN
cord-280549-bsnz24jx	724	39	by	by	IN
cord-280549-bsnz24jx	724	40	viral	viral	JJ
cord-280549-bsnz24jx	724	41	protein	protein	NN
cord-280549-bsnz24jx	724	42	with	with	IN
cord-280549-bsnz24jx	724	43	cyclin	cyclin	NN
cord-280549-bsnz24jx	724	44	-	-	HYPH
cord-280549-bsnz24jx	724	45	dependent	dependent	JJ
cord-280549-bsnz24jx	724	46	kinase	kinase	NN
cord-280549-bsnz24jx	724	47	function	function	NN
cord-280549-bsnz24jx	725	1	Maturation	maturation	NN
cord-280549-bsnz24jx	725	2	promoting	promote	VBG
cord-280549-bsnz24jx	725	3	factor	factor	NN
cord-280549-bsnz24jx	725	4	,	,	,
cord-280549-bsnz24jx	725	5	cyclin	cyclin	NN
cord-280549-bsnz24jx	725	6	and	and	CC
cord-280549-bsnz24jx	725	7	the	the	DT
cord-280549-bsnz24jx	725	8	control	control	NN
cord-280549-bsnz24jx	725	9	of	of	IN
cord-280549-bsnz24jx	725	10	M	M	NNP
cord-280549-bsnz24jx	725	11	-	-	HYPH
cord-280549-bsnz24jx	725	12	phase	phase	NN
cord-280549-bsnz24jx	725	13	Identification	identification	NN
cord-280549-bsnz24jx	725	14	of	of	IN
cord-280549-bsnz24jx	725	15	distinct	distinct	JJ
cord-280549-bsnz24jx	725	16	roles	role	NNS
cord-280549-bsnz24jx	725	17	for	for	IN
cord-280549-bsnz24jx	725	18	separate	separate	JJ
cord-280549-bsnz24jx	725	19	E1A	e1a	NN
cord-280549-bsnz24jx	725	20	domains	domain	NNS
cord-280549-bsnz24jx	725	21	in	in	IN
cord-280549-bsnz24jx	725	22	disruption	disruption	NN
cord-280549-bsnz24jx	725	23	of	of	IN
cord-280549-bsnz24jx	725	24	E2F	e2f	NN
cord-280549-bsnz24jx	725	25	complexes	complex	NNS
cord-280549-bsnz24jx	725	26	Epstein	Epstein	NNP
cord-280549-bsnz24jx	725	27	-	-	HYPH
cord-280549-bsnz24jx	725	28	Barr	Barr	NNP
cord-280549-bsnz24jx	725	29	virus	virus	NN
cord-280549-bsnz24jx	725	30	EBNA	EBNA	NNP
cord-280549-bsnz24jx	725	31	-	-	HYPH
cord-280549-bsnz24jx	725	32	LP	LP	NNP
cord-280549-bsnz24jx	725	33	and	and	CC
cord-280549-bsnz24jx	725	34	transcription	transcription	NN
cord-280549-bsnz24jx	725	35	regulation	regulation	NN
cord-280549-bsnz24jx	725	36	properties	property	NNS
cord-280549-bsnz24jx	725	37	of	of	IN
cord-280549-bsnz24jx	725	38	pRB	pRB	NNP
cord-280549-bsnz24jx	725	39	,	,	,
cord-280549-bsnz24jx	725	40	p107	p107	NNP
cord-280549-bsnz24jx	725	41	and	and	CC
cord-280549-bsnz24jx	725	42	p53	p53	NN
cord-280549-bsnz24jx	725	43	in	in	IN
cord-280549-bsnz24jx	726	1	transfection	transfection	NN
cord-280549-bsnz24jx	726	2	assays	assays	NNP
cord-280549-bsnz24jx	726	3	Damage	damage	NN
cord-280549-bsnz24jx	726	4	-	-	HYPH
cord-280549-bsnz24jx	726	5	specific	specific	JJ
cord-280549-bsnz24jx	726	6	DNA	dna	NN
cord-280549-bsnz24jx	726	7	binding	bind	VBG
cord-280549-bsnz24jx	726	8	protein	protein	NN
cord-280549-bsnz24jx	726	9	1	1	CD
cord-280549-bsnz24jx	726	10	(	(	-LRB-
cord-280549-bsnz24jx	726	11	DDB1	DDB1	NNP
cord-280549-bsnz24jx	726	12	)	)	-RRB-
cord-280549-bsnz24jx	726	13	:	:	:
cord-280549-bsnz24jx	727	1	a	a	DT
cord-280549-bsnz24jx	727	2	protein	protein	NN
cord-280549-bsnz24jx	727	3	with	with	IN
cord-280549-bsnz24jx	727	4	a	a	DT
cord-280549-bsnz24jx	727	5	wide	wide	JJ
cord-280549-bsnz24jx	727	6	range	range	NN
cord-280549-bsnz24jx	727	7	of	of	IN
cord-280549-bsnz24jx	727	8	functions	function	NNS
cord-280549-bsnz24jx	727	9	Genes	gene	NNS
cord-280549-bsnz24jx	727	10	involved	involve	VBN
cord-280549-bsnz24jx	727	11	in	in	IN
cord-280549-bsnz24jx	727	12	sister	sister	NN
cord-280549-bsnz24jx	727	13	chromatid	chromatid	NN
cord-280549-bsnz24jx	727	14	separation	separation	NN
cord-280549-bsnz24jx	727	15	are	be	VBP
cord-280549-bsnz24jx	727	16	needed	need	VBN
cord-280549-bsnz24jx	727	17	for	for	IN
cord-280549-bsnz24jx	727	18	B	b	NN
cord-280549-bsnz24jx	727	19	-	-	HYPH
cord-280549-bsnz24jx	727	20	type	type	NN
cord-280549-bsnz24jx	727	21	cyclin	cyclin	NN
cord-280549-bsnz24jx	727	22	proteolysis	proteolysis	NN
cord-280549-bsnz24jx	727	23	in	in	IN
cord-280549-bsnz24jx	727	24	budding	bud	VBG
cord-280549-bsnz24jx	727	25	yeast	yeast	NN
cord-280549-bsnz24jx	727	26	Phosphorylation	Phosphorylation	NNP
cord-280549-bsnz24jx	727	27	of	of	IN
cord-280549-bsnz24jx	727	28	p27Kip1	p27kip1	CD
cord-280549-bsnz24jx	727	29	on	on	IN
cord-280549-bsnz24jx	727	30	serine	serine	NN
cord-280549-bsnz24jx	727	31	10	10	CD
cord-280549-bsnz24jx	727	32	is	be	VBZ
cord-280549-bsnz24jx	727	33	required	require	VBN
cord-280549-bsnz24jx	727	34	for	for	IN
cord-280549-bsnz24jx	727	35	its	-PRON-	PRP$
cord-280549-bsnz24jx	727	36	binding	binding	NN
cord-280549-bsnz24jx	727	37	to	to	IN
cord-280549-bsnz24jx	727	38	CRM1	CRM1	NNP
cord-280549-bsnz24jx	727	39	and	and	CC
cord-280549-bsnz24jx	727	40	nuclear	nuclear	JJ
cord-280549-bsnz24jx	727	41	export	export	NN
cord-280549-bsnz24jx	727	42	Complex	Complex	NNP
cord-280549-bsnz24jx	727	43	formation	formation	NN
cord-280549-bsnz24jx	727	44	of	of	IN
cord-280549-bsnz24jx	727	45	the	the	DT
cord-280549-bsnz24jx	727	46	nonstructural	nonstructural	JJ
cord-280549-bsnz24jx	727	47	protein	protein	NNP
cord-280549-bsnz24jx	727	48	3	3	CD
cord-280549-bsnz24jx	727	49	of	of	IN
cord-280549-bsnz24jx	727	50	hepatitis	hepatitis	NNP
cord-280549-bsnz24jx	727	51	C	C	NNP
cord-280549-bsnz24jx	727	52	virus	virus	NN
cord-280549-bsnz24jx	727	53	with	with	IN
cord-280549-bsnz24jx	727	54	the	the	DT
cord-280549-bsnz24jx	727	55	p53	p53	NN
cord-280549-bsnz24jx	727	56	tumor	tumor	NN
cord-280549-bsnz24jx	727	57	suppressor	suppressor	NN
cord-280549-bsnz24jx	727	58	Activation	Activation	NNP
cord-280549-bsnz24jx	727	59	of	of	IN
cord-280549-bsnz24jx	727	60	the	the	DT
cord-280549-bsnz24jx	727	61	cyclin	cyclin	NN
cord-280549-bsnz24jx	727	62	D2	d2	NN
cord-280549-bsnz24jx	727	63	and	and	CC
cord-280549-bsnz24jx	727	64	cdk6	cdk6	NNP
cord-280549-bsnz24jx	727	65	genes	gene	NNS
cord-280549-bsnz24jx	727	66	through	through	IN
cord-280549-bsnz24jx	727	67	NF	NF	NNP
cord-280549-bsnz24jx	727	68	-	-	HYPH
cord-280549-bsnz24jx	727	69	kappaB	kappaB	NNP
cord-280549-bsnz24jx	727	70	is	be	VBZ
cord-280549-bsnz24jx	727	71	critical	critical	JJ
cord-280549-bsnz24jx	727	72	for	for	IN
cord-280549-bsnz24jx	727	73	cell	cell	NN
cord-280549-bsnz24jx	727	74	-	-	HYPH
cord-280549-bsnz24jx	727	75	cycle	cycle	NN
cord-280549-bsnz24jx	727	76	progression	progression	NN
cord-280549-bsnz24jx	727	77	induced	induce	VBN
cord-280549-bsnz24jx	727	78	by	by	IN
cord-280549-bsnz24jx	727	79	HTLV	HTLV	NNP
cord-280549-bsnz24jx	727	80	-	-	HYPH
cord-280549-bsnz24jx	727	81	I	I	NNP
cord-280549-bsnz24jx	727	82	Tax	tax	VBP
cord-280549-bsnz24jx	727	83	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	727	84	viral	viral	JJ
cord-280549-bsnz24jx	727	85	infectivity	infectivity	NN
cord-280549-bsnz24jx	727	86	factor	factor	NN
cord-280549-bsnz24jx	727	87	interacts	interact	VBZ
cord-280549-bsnz24jx	727	88	with	with	IN
cord-280549-bsnz24jx	727	89	TP53	TP53	NNP
cord-280549-bsnz24jx	727	90	to	to	TO
cord-280549-bsnz24jx	727	91	induce	induce	VB
cord-280549-bsnz24jx	727	92	G2	G2	NNP
cord-280549-bsnz24jx	727	93	cell	cell	NN
cord-280549-bsnz24jx	727	94	cycle	cycle	NN
cord-280549-bsnz24jx	727	95	arrest	arrest	NN
cord-280549-bsnz24jx	727	96	and	and	CC
cord-280549-bsnz24jx	727	97	positively	positively	RB
cord-280549-bsnz24jx	727	98	regulate	regulate	VB
cord-280549-bsnz24jx	727	99	viral	viral	JJ
cord-280549-bsnz24jx	727	100	replication	replication	NN
cord-280549-bsnz24jx	727	101	MDM2	MDM2	NNP
cord-280549-bsnz24jx	727	102	is	be	VBZ
cord-280549-bsnz24jx	727	103	a	a	DT
cord-280549-bsnz24jx	727	104	novel	novel	JJ
cord-280549-bsnz24jx	727	105	E3	e3	NN
cord-280549-bsnz24jx	727	106	ligase	ligase	NN
cord-280549-bsnz24jx	727	107	for	for	IN
cord-280549-bsnz24jx	727	108	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	727	109	Vif	Vif	NNP
cord-280549-bsnz24jx	727	110	Cell	Cell	NNP
cord-280549-bsnz24jx	727	111	cycle	cycle	NN
cord-280549-bsnz24jx	727	112	regulation	regulation	NN
cord-280549-bsnz24jx	727	113	by	by	IN
cord-280549-bsnz24jx	727	114	Kaposi	Kaposi	NNP
cord-280549-bsnz24jx	727	115	's	's	POS
cord-280549-bsnz24jx	727	116	sarcoma	sarcoma	NN
cord-280549-bsnz24jx	727	117	-	-	HYPH
cord-280549-bsnz24jx	727	118	associated	associate	VBN
cord-280549-bsnz24jx	727	119	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	727	120	K	K	NNP
cord-280549-bsnz24jx	727	121	-	-	HYPH
cord-280549-bsnz24jx	727	122	bZIP	bzip	XX
cord-280549-bsnz24jx	727	123	:	:	:
cord-280549-bsnz24jx	728	1	Direct	direct	JJ
cord-280549-bsnz24jx	728	2	interaction	interaction	NN
cord-280549-bsnz24jx	728	3	with	with	IN
cord-280549-bsnz24jx	728	4	cyclin	cyclin	NN
cord-280549-bsnz24jx	728	5	-	-	:
cord-280549-bsnz24jx	728	6	CDK2	CDK2	NNP
cord-280549-bsnz24jx	728	7	and	and	CC
cord-280549-bsnz24jx	728	8	induction	induction	NN
cord-280549-bsnz24jx	728	9	of	of	IN
cord-280549-bsnz24jx	728	10	G(1	G(1	NNP
cord-280549-bsnz24jx	728	11	)	)	-RRB-
cord-280549-bsnz24jx	729	1	growth	growth	NN
cord-280549-bsnz24jx	729	2	arrest	arrest	NN
cord-280549-bsnz24jx	729	3	Influenza	Influenza	NNP
cord-280549-bsnz24jx	729	4	A	a	DT
cord-280549-bsnz24jx	729	5	virus	virus	NN
cord-280549-bsnz24jx	729	6	NS1	ns1	NN
cord-280549-bsnz24jx	729	7	induces	induce	VBZ
cord-280549-bsnz24jx	729	8	G0	G0	NNP
cord-280549-bsnz24jx	729	9	/	/	SYM
cord-280549-bsnz24jx	729	10	G1	G1	NNP
cord-280549-bsnz24jx	729	11	cell	cell	NN
cord-280549-bsnz24jx	729	12	cycle	cycle	NN
cord-280549-bsnz24jx	729	13	arrest	arrest	NN
cord-280549-bsnz24jx	729	14	by	by	IN
cord-280549-bsnz24jx	729	15	inhibiting	inhibit	VBG
cord-280549-bsnz24jx	729	16	the	the	DT
cord-280549-bsnz24jx	729	17	expression	expression	NN
cord-280549-bsnz24jx	729	18	and	and	CC
cord-280549-bsnz24jx	729	19	activity	activity	NN
cord-280549-bsnz24jx	729	20	of	of	IN
cord-280549-bsnz24jx	729	21	RhoA	RhoA	NNP
cord-280549-bsnz24jx	729	22	protein	protein	NN
cord-280549-bsnz24jx	729	23	Co	co	NN
cord-280549-bsnz24jx	729	24	-	-	NN
cord-280549-bsnz24jx	729	25	localization	localization	NN
cord-280549-bsnz24jx	729	26	of	of	IN
cord-280549-bsnz24jx	729	27	the	the	DT
cord-280549-bsnz24jx	729	28	retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	729	29	protein	protein	NN
cord-280549-bsnz24jx	729	30	and	and	CC
cord-280549-bsnz24jx	729	31	the	the	DT
cord-280549-bsnz24jx	729	32	Epstein	Epstein	NNP
cord-280549-bsnz24jx	729	33	-	-	HYPH
cord-280549-bsnz24jx	729	34	Barr	Barr	NNP
cord-280549-bsnz24jx	729	35	virus	virus	NN
cord-280549-bsnz24jx	729	36	-	-	HYPH
cord-280549-bsnz24jx	729	37	encoded	encode	VBN
cord-280549-bsnz24jx	729	38	nuclear	nuclear	JJ
cord-280549-bsnz24jx	729	39	antigen	antigen	NN
cord-280549-bsnz24jx	729	40	EBNA-5	EBNA-5	NNP
cord-280549-bsnz24jx	729	41	Role	role	NN
cord-280549-bsnz24jx	729	42	of	of	IN
cord-280549-bsnz24jx	729	43	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	729	44	CDC2	CDC2	NNP
cord-280549-bsnz24jx	729	45	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	729	46	in	in	IN
cord-280549-bsnz24jx	729	47	radiation	radiation	NN
cord-280549-bsnz24jx	729	48	-	-	HYPH
cord-280549-bsnz24jx	729	49	induced	induce	VBN
cord-280549-bsnz24jx	729	50	G2	G2	NNP
cord-280549-bsnz24jx	729	51	arrest	arrest	NN
cord-280549-bsnz24jx	729	52	in	in	IN
cord-280549-bsnz24jx	729	53	human	human	JJ
cord-280549-bsnz24jx	729	54	cells	cell	NNS
cord-280549-bsnz24jx	729	55	Domain	Domain	NNP
cord-280549-bsnz24jx	729	56	mapping	mapping	NN
cord-280549-bsnz24jx	729	57	of	of	IN
cord-280549-bsnz24jx	729	58	the	the	DT
cord-280549-bsnz24jx	729	59	human	human	JJ
cord-280549-bsnz24jx	729	60	cytomegalovirus	cytomegalovirus	NNP
cord-280549-bsnz24jx	729	61	IE1	IE1	NNP
cord-280549-bsnz24jx	729	62	-	-	HYPH
cord-280549-bsnz24jx	729	63	72	72	CD
cord-280549-bsnz24jx	729	64	and	and	CC
cord-280549-bsnz24jx	729	65	cellular	cellular	JJ
cord-280549-bsnz24jx	729	66	p107	p107	NNP
cord-280549-bsnz24jx	729	67	protein	protein	NN
cord-280549-bsnz24jx	729	68	-	-	HYPH
cord-280549-bsnz24jx	729	69	protein	protein	NN
cord-280549-bsnz24jx	729	70	interaction	interaction	NN
cord-280549-bsnz24jx	729	71	and	and	CC
cord-280549-bsnz24jx	729	72	the	the	DT
cord-280549-bsnz24jx	729	73	possible	possible	JJ
cord-280549-bsnz24jx	729	74	functional	functional	JJ
cord-280549-bsnz24jx	729	75	consequences	consequence	NNS
cord-280549-bsnz24jx	730	1	The	the	DT
cord-280549-bsnz24jx	730	2	human	human	JJ
cord-280549-bsnz24jx	730	3	papillomavirus	papillomavirus	NN
cord-280549-bsnz24jx	730	4	E7	E7	NNP
cord-280549-bsnz24jx	730	5	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	730	6	can	can	MD
cord-280549-bsnz24jx	730	7	uncouple	uncouple	VB
cord-280549-bsnz24jx	730	8	cellular	cellular	JJ
cord-280549-bsnz24jx	730	9	differentiation	differentiation	NN
cord-280549-bsnz24jx	730	10	and	and	CC
cord-280549-bsnz24jx	730	11	proliferation	proliferation	NN
cord-280549-bsnz24jx	730	12	in	in	IN
cord-280549-bsnz24jx	730	13	human	human	JJ
cord-280549-bsnz24jx	730	14	keratinocytes	keratinocyte	NNS
cord-280549-bsnz24jx	730	15	by	by	IN
cord-280549-bsnz24jx	730	16	abrogating	abrogate	VBG
cord-280549-bsnz24jx	730	17	p21Cip1-mediated	p21cip1-mediated	CD
cord-280549-bsnz24jx	730	18	inhibition	inhibition	NN
cord-280549-bsnz24jx	730	19	of	of	IN
cord-280549-bsnz24jx	730	20	cdk2	cdk2	NNP
cord-280549-bsnz24jx	730	21	Virus	Virus	NNP
cord-280549-bsnz24jx	730	22	-	-	HYPH
cord-280549-bsnz24jx	730	23	encoded	encode	VBN
cord-280549-bsnz24jx	730	24	cyclin	cyclin	NN
cord-280549-bsnz24jx	731	1	The	the	DT
cord-280549-bsnz24jx	731	2	cdk	cdk	NNP
cord-280549-bsnz24jx	731	3	-	-	HYPH
cord-280549-bsnz24jx	731	4	activating	activate	VBG
cord-280549-bsnz24jx	731	5	kinase	kinase	NN
cord-280549-bsnz24jx	731	6	(	(	-LRB-
cord-280549-bsnz24jx	731	7	CAK	CAK	NNP
cord-280549-bsnz24jx	731	8	)	)	-RRB-
cord-280549-bsnz24jx	731	9	:	:	:
cord-280549-bsnz24jx	732	1	from	from	IN
cord-280549-bsnz24jx	732	2	yeast	yeast	NN
cord-280549-bsnz24jx	732	3	to	to	IN
cord-280549-bsnz24jx	732	4	mammals	mammal	NNS
cord-280549-bsnz24jx	732	5	Human	Human	NNP
cord-280549-bsnz24jx	732	6	and	and	CC
cord-280549-bsnz24jx	732	7	yeast	yeast	NNP
cord-280549-bsnz24jx	732	8	cdk	cdk	NNP
cord-280549-bsnz24jx	732	9	-	-	HYPH
cord-280549-bsnz24jx	732	10	activating	activate	VBG
cord-280549-bsnz24jx	732	11	kinases	kinase	NNS
cord-280549-bsnz24jx	732	12	(	(	-LRB-
cord-280549-bsnz24jx	732	13	CAKs	caks	NN
cord-280549-bsnz24jx	732	14	)	)	-RRB-
cord-280549-bsnz24jx	732	15	display	display	NN
cord-280549-bsnz24jx	732	16	distinct	distinct	JJ
cord-280549-bsnz24jx	732	17	substrate	substrate	NN
cord-280549-bsnz24jx	732	18	specificities	specificity	NNS
cord-280549-bsnz24jx	732	19	Human	human	JJ
cord-280549-bsnz24jx	732	20	immunodeficiency	immunodeficiency	NN
cord-280549-bsnz24jx	732	21	virus	virus	NN
cord-280549-bsnz24jx	732	22	type	type	NN
cord-280549-bsnz24jx	732	23	1	1	CD
cord-280549-bsnz24jx	732	24	Vpr	Vpr	NNP
cord-280549-bsnz24jx	732	25	binds	bind	VBZ
cord-280549-bsnz24jx	732	26	to	to	IN
cord-280549-bsnz24jx	732	27	the	the	DT
cord-280549-bsnz24jx	732	28	N	N	NNP
cord-280549-bsnz24jx	732	29	lobe	lobe	NN
cord-280549-bsnz24jx	732	30	of	of	IN
cord-280549-bsnz24jx	732	31	the	the	DT
cord-280549-bsnz24jx	732	32	Wee1	Wee1	NNP
cord-280549-bsnz24jx	732	33	kinase	kinase	NN
cord-280549-bsnz24jx	732	34	domain	domain	NN
cord-280549-bsnz24jx	732	35	and	and	CC
cord-280549-bsnz24jx	732	36	enhances	enhance	VBZ
cord-280549-bsnz24jx	732	37	kinase	kinase	NN
cord-280549-bsnz24jx	732	38	activity	activity	NN
cord-280549-bsnz24jx	732	39	for	for	IN
cord-280549-bsnz24jx	732	40	CDC2	CDC2	NNP
cord-280549-bsnz24jx	732	41	Regulation	Regulation	NNP
cord-280549-bsnz24jx	732	42	of	of	IN
cord-280549-bsnz24jx	732	43	cyclin	cyclin	NN
cord-280549-bsnz24jx	732	44	D	d	NN
cord-280549-bsnz24jx	732	45	-	-	HYPH
cord-280549-bsnz24jx	732	46	dependent	dependent	JJ
cord-280549-bsnz24jx	732	47	kinase	kinase	NN
cord-280549-bsnz24jx	732	48	4	4	CD
cord-280549-bsnz24jx	732	49	(	(	-LRB-
cord-280549-bsnz24jx	732	50	cdk4	cdk4	ADD
cord-280549-bsnz24jx	732	51	)	)	-RRB-
cord-280549-bsnz24jx	732	52	by	by	IN
cord-280549-bsnz24jx	732	53	cdk4-activating	cdk4-activate	VBG
cord-280549-bsnz24jx	732	54	kinase	kinase	NN
cord-280549-bsnz24jx	732	55	Extended	extended	JJ
cord-280549-bsnz24jx	732	56	stability	stability	NN
cord-280549-bsnz24jx	732	57	of	of	IN
cord-280549-bsnz24jx	732	58	cyclin	cyclin	NN
cord-280549-bsnz24jx	732	59	D1	d1	NN
cord-280549-bsnz24jx	732	60	contributes	contribute	VBZ
cord-280549-bsnz24jx	732	61	to	to	IN
cord-280549-bsnz24jx	732	62	limited	limited	JJ
cord-280549-bsnz24jx	732	63	cell	cell	NN
cord-280549-bsnz24jx	732	64	cycle	cycle	NN
cord-280549-bsnz24jx	732	65	arrest	arrest	NN
cord-280549-bsnz24jx	732	66	at	at	IN
cord-280549-bsnz24jx	732	67	G1-phase	G1-phase	NNP
cord-280549-bsnz24jx	732	68	in	in	IN
cord-280549-bsnz24jx	732	69	BHK-21	BHK-21	NNP
cord-280549-bsnz24jx	732	70	cells	cell	NNS
cord-280549-bsnz24jx	732	71	with	with	IN
cord-280549-bsnz24jx	732	72	Japanese	japanese	JJ
cord-280549-bsnz24jx	732	73	encephalitis	encephalitis	RB
cord-280549-bsnz24jx	732	74	virus	virus	NN
cord-280549-bsnz24jx	732	75	persistent	persistent	JJ
cord-280549-bsnz24jx	732	76	infection	infection	NN
cord-280549-bsnz24jx	732	77	Regulation	regulation	NN
cord-280549-bsnz24jx	732	78	of	of	IN
cord-280549-bsnz24jx	732	79	multiple	multiple	JJ
cord-280549-bsnz24jx	732	80	DNA	dna	NN
cord-280549-bsnz24jx	732	81	repair	repair	NN
cord-280549-bsnz24jx	732	82	pathways	pathway	NNS
cord-280549-bsnz24jx	732	83	by	by	IN
cord-280549-bsnz24jx	732	84	the	the	DT
cord-280549-bsnz24jx	732	85	Fanconi	Fanconi	NNP
cord-280549-bsnz24jx	732	86	anemia	anemia	NN
cord-280549-bsnz24jx	732	87	protein	protein	NN
cord-280549-bsnz24jx	733	1	SLX4	SLX4	NNP
cord-280549-bsnz24jx	733	2	A	a	DT
cord-280549-bsnz24jx	733	3	20S	20s	CD
cord-280549-bsnz24jx	733	4	complex	complex	NN
cord-280549-bsnz24jx	733	5	containing	contain	VBG
cord-280549-bsnz24jx	733	6	CDC27	CDC27	NNP
cord-280549-bsnz24jx	733	7	and	and	CC
cord-280549-bsnz24jx	733	8	CDC16	CDC16	NNP
cord-280549-bsnz24jx	733	9	catalyzes	catalyze	VBZ
cord-280549-bsnz24jx	733	10	the	the	DT
cord-280549-bsnz24jx	733	11	mitosis	mitosis	NN
cord-280549-bsnz24jx	733	12	-	-	HYPH
cord-280549-bsnz24jx	733	13	specific	specific	JJ
cord-280549-bsnz24jx	733	14	conjugation	conjugation	NN
cord-280549-bsnz24jx	733	15	of	of	IN
cord-280549-bsnz24jx	733	16	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	733	17	to	to	IN
cord-280549-bsnz24jx	733	18	cyclin	cyclin	NN
cord-280549-bsnz24jx	733	19	B	B	NNP
cord-280549-bsnz24jx	733	20	Vpr	Vpr	NNP
cord-280549-bsnz24jx	733	21	protein	protein	NN
cord-280549-bsnz24jx	733	22	of	of	IN
cord-280549-bsnz24jx	733	23	human	human	JJ
cord-280549-bsnz24jx	733	24	immunodeficiency	immunodeficiency	NN
cord-280549-bsnz24jx	733	25	virus	virus	NN
cord-280549-bsnz24jx	733	26	type	type	NN
cord-280549-bsnz24jx	733	27	1	1	CD
cord-280549-bsnz24jx	733	28	binds	bind	VBZ
cord-280549-bsnz24jx	733	29	to	to	IN
cord-280549-bsnz24jx	733	30	14	14	CD
cord-280549-bsnz24jx	733	31	-	-	SYM
cord-280549-bsnz24jx	733	32	3	3	CD
cord-280549-bsnz24jx	733	33	-	-	SYM
cord-280549-bsnz24jx	733	34	3	3	CD
cord-280549-bsnz24jx	733	35	proteins	protein	NNS
cord-280549-bsnz24jx	733	36	and	and	CC
cord-280549-bsnz24jx	733	37	facilitates	facilitate	VBZ
cord-280549-bsnz24jx	733	38	complex	complex	JJ
cord-280549-bsnz24jx	733	39	formation	formation	NN
cord-280549-bsnz24jx	733	40	with	with	IN
cord-280549-bsnz24jx	733	41	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	733	42	:	:	:
cord-280549-bsnz24jx	734	1	implications	implication	NNS
cord-280549-bsnz24jx	734	2	for	for	IN
cord-280549-bsnz24jx	734	3	cell	cell	NN
cord-280549-bsnz24jx	734	4	cycle	cycle	NN
cord-280549-bsnz24jx	734	5	arrest	arrest	NN
cord-280549-bsnz24jx	734	6	Epstein	Epstein	NNP
cord-280549-bsnz24jx	734	7	-	-	HYPH
cord-280549-bsnz24jx	734	8	Barr	Barr	NNP
cord-280549-bsnz24jx	734	9	virus	virus	NN
cord-280549-bsnz24jx	735	1	nuclear	nuclear	JJ
cord-280549-bsnz24jx	735	2	antigen	antigen	NNP
cord-280549-bsnz24jx	735	3	3C	3C	NNP
cord-280549-bsnz24jx	735	4	regulates	regulate	VBZ
cord-280549-bsnz24jx	735	5	cyclin	cyclin	NNP
cord-280549-bsnz24jx	735	6	A	A	NNP
cord-280549-bsnz24jx	735	7	/	/	SYM
cord-280549-bsnz24jx	735	8	p27	p27	NN
cord-280549-bsnz24jx	735	9	complexes	complex	NNS
cord-280549-bsnz24jx	735	10	and	and	CC
cord-280549-bsnz24jx	735	11	enhances	enhance	VBZ
cord-280549-bsnz24jx	735	12	cyclin	cyclin	NN
cord-280549-bsnz24jx	735	13	A	a	NN
cord-280549-bsnz24jx	735	14	-	-	HYPH
cord-280549-bsnz24jx	735	15	dependent	dependent	JJ
cord-280549-bsnz24jx	735	16	kinase	kinase	NN
cord-280549-bsnz24jx	735	17	activity	activity	NN
cord-280549-bsnz24jx	736	1	The	the	DT
cord-280549-bsnz24jx	736	2	canonical	canonical	JJ
cord-280549-bsnz24jx	736	3	Notch	notch	NN
cord-280549-bsnz24jx	736	4	signaling	signal	VBG
cord-280549-bsnz24jx	736	5	pathway	pathway	NN
cord-280549-bsnz24jx	736	6	:	:	:
cord-280549-bsnz24jx	736	7	unfolding	unfold	VBG
cord-280549-bsnz24jx	736	8	the	the	DT
cord-280549-bsnz24jx	736	9	activation	activation	NN
cord-280549-bsnz24jx	736	10	mechanism	mechanism	NN
cord-280549-bsnz24jx	737	1	Cytoplasmic	cytoplasmic	JJ
cord-280549-bsnz24jx	737	2	sequestration	sequestration	NN
cord-280549-bsnz24jx	737	3	of	of	IN
cord-280549-bsnz24jx	737	4	p53	p53	NN
cord-280549-bsnz24jx	737	5	in	in	IN
cord-280549-bsnz24jx	737	6	cytomegalovirus	cytomegalovirus	NN
cord-280549-bsnz24jx	737	7	-	-	HYPH
cord-280549-bsnz24jx	737	8	infected	infect	VBN
cord-280549-bsnz24jx	737	9	human	human	JJ
cord-280549-bsnz24jx	737	10	endothelial	endothelial	NN
cord-280549-bsnz24jx	737	11	cells	cell	NNS
cord-280549-bsnz24jx	738	1	Mouse	mouse	NN
cord-280549-bsnz24jx	738	2	development	development	NN
cord-280549-bsnz24jx	738	3	and	and	CC
cord-280549-bsnz24jx	738	4	cell	cell	NN
cord-280549-bsnz24jx	738	5	proliferation	proliferation	NN
cord-280549-bsnz24jx	738	6	in	in	IN
cord-280549-bsnz24jx	738	7	the	the	DT
cord-280549-bsnz24jx	738	8	absence	absence	NN
cord-280549-bsnz24jx	738	9	of	of	IN
cord-280549-bsnz24jx	738	10	D	d	NN
cord-280549-bsnz24jx	738	11	-	-	HYPH
cord-280549-bsnz24jx	738	12	cyclins	cyclin	NNS
cord-280549-bsnz24jx	738	13	Cell	cell	NN
cord-280549-bsnz24jx	738	14	cycle	cycle	NN
cord-280549-bsnz24jx	738	15	regulation	regulation	NN
cord-280549-bsnz24jx	738	16	of	of	IN
cord-280549-bsnz24jx	738	17	vertebrate	vertebrate	NN
cord-280549-bsnz24jx	738	18	p34cdc2	p34cdc2	NNP
cord-280549-bsnz24jx	738	19	activity	activity	NN
cord-280549-bsnz24jx	738	20	:	:	:
cord-280549-bsnz24jx	738	21	identification	identification	NN
cord-280549-bsnz24jx	738	22	of	of	IN
cord-280549-bsnz24jx	738	23	Thr161	thr161	CD
cord-280549-bsnz24jx	738	24	as	as	IN
cord-280549-bsnz24jx	738	25	an	an	DT
cord-280549-bsnz24jx	738	26	essential	essential	JJ
cord-280549-bsnz24jx	738	27	in	in	IN
cord-280549-bsnz24jx	738	28	vivo	vivo	NN
cord-280549-bsnz24jx	738	29	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	738	30	site	site	NN
cord-280549-bsnz24jx	738	31	Cyclin	Cyclin	NNP
cord-280549-bsnz24jx	738	32	/	/	SYM
cord-280549-bsnz24jx	738	33	Cdk	Cdk	NNP
cord-280549-bsnz24jx	738	34	-	-	HYPH
cord-280549-bsnz24jx	738	35	dependent	dependent	JJ
cord-280549-bsnz24jx	738	36	initiation	initiation	NN
cord-280549-bsnz24jx	738	37	of	of	IN
cord-280549-bsnz24jx	738	38	DNA	dna	NN
cord-280549-bsnz24jx	738	39	replication	replication	NN
cord-280549-bsnz24jx	738	40	in	in	IN
cord-280549-bsnz24jx	738	41	a	a	DT
cord-280549-bsnz24jx	738	42	human	human	JJ
cord-280549-bsnz24jx	738	43	cell	cell	NN
cord-280549-bsnz24jx	738	44	-	-	HYPH
cord-280549-bsnz24jx	738	45	free	free	JJ
cord-280549-bsnz24jx	738	46	system	system	NN
cord-280549-bsnz24jx	738	47	Activation	activation	NN
cord-280549-bsnz24jx	738	48	of	of	IN
cord-280549-bsnz24jx	738	49	the	the	DT
cord-280549-bsnz24jx	738	50	anaphase	anaphase	NN
cord-280549-bsnz24jx	738	51	promoting	promote	VBG
cord-280549-bsnz24jx	738	52	complex	complex	NN
cord-280549-bsnz24jx	738	53	by	by	IN
cord-280549-bsnz24jx	738	54	HTLV-1	HTLV-1	NNP
cord-280549-bsnz24jx	738	55	tax	tax	NN
cord-280549-bsnz24jx	738	56	leads	lead	NNS
cord-280549-bsnz24jx	738	57	to	to	TO
cord-280549-bsnz24jx	738	58	senescence	senescence	VB
cord-280549-bsnz24jx	738	59	Cyclin	Cyclin	NNP
cord-280549-bsnz24jx	738	60	-	-	HYPH
cord-280549-bsnz24jx	738	61	dependent	dependent	JJ
cord-280549-bsnz24jx	738	62	kinase	kinase	NN
cord-280549-bsnz24jx	738	63	control	control	NN
cord-280549-bsnz24jx	738	64	of	of	IN
cord-280549-bsnz24jx	738	65	centrosome	centrosome	NN
cord-280549-bsnz24jx	738	66	duplication	duplication	NN
cord-280549-bsnz24jx	739	1	Premature	premature	JJ
cord-280549-bsnz24jx	739	2	activation	activation	NN
cord-280549-bsnz24jx	739	3	of	of	IN
cord-280549-bsnz24jx	739	4	the	the	DT
cord-280549-bsnz24jx	739	5	SLX4	SLX4	NNP
cord-280549-bsnz24jx	739	6	complex	complex	NN
cord-280549-bsnz24jx	739	7	by	by	IN
cord-280549-bsnz24jx	739	8	Vpr	Vpr	NNP
cord-280549-bsnz24jx	739	9	promotes	promote	VBZ
cord-280549-bsnz24jx	739	10	G2	G2	NNP
cord-280549-bsnz24jx	739	11	/	/	SYM
cord-280549-bsnz24jx	739	12	M	M	NNP
cord-280549-bsnz24jx	739	13	arrest	arrest	NN
cord-280549-bsnz24jx	739	14	and	and	CC
cord-280549-bsnz24jx	739	15	escape	escape	VB
cord-280549-bsnz24jx	739	16	from	from	IN
cord-280549-bsnz24jx	739	17	innate	innate	JJ
cord-280549-bsnz24jx	739	18	immune	immune	JJ
cord-280549-bsnz24jx	739	19	sensing	sensing	NN
cord-280549-bsnz24jx	739	20	Activation	Activation	NNP
cord-280549-bsnz24jx	739	21	of	of	IN
cord-280549-bsnz24jx	739	22	the	the	DT
cord-280549-bsnz24jx	739	23	ATR	ATR	NNP
cord-280549-bsnz24jx	739	24	pathway	pathway	NN
cord-280549-bsnz24jx	739	25	by	by	IN
cord-280549-bsnz24jx	739	26	human	human	JJ
cord-280549-bsnz24jx	739	27	immunodeficiency	immunodeficiency	NN
cord-280549-bsnz24jx	739	28	virus	virus	NN
cord-280549-bsnz24jx	739	29	type	type	NN
cord-280549-bsnz24jx	740	1	1	1	LS
cord-280549-bsnz24jx	740	2	Vpr	Vpr	NNP
cord-280549-bsnz24jx	740	3	involves	involve	VBZ
cord-280549-bsnz24jx	740	4	its	-PRON-	PRP$
cord-280549-bsnz24jx	740	5	direct	direct	JJ
cord-280549-bsnz24jx	740	6	binding	binding	NN
cord-280549-bsnz24jx	740	7	to	to	TO
cord-280549-bsnz24jx	740	8	chromatin	chromatin	VB
cord-280549-bsnz24jx	740	9	in	in	IN
cord-280549-bsnz24jx	740	10	vivo	vivo	NNP
cord-280549-bsnz24jx	740	11	HCV	HCV	NNP
cord-280549-bsnz24jx	740	12	NS5A	NS5A	NNP
cord-280549-bsnz24jx	740	13	interacts	interact	VBZ
cord-280549-bsnz24jx	740	14	with	with	IN
cord-280549-bsnz24jx	740	15	p53	p53	NN
cord-280549-bsnz24jx	740	16	and	and	CC
cord-280549-bsnz24jx	740	17	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	740	18	p53-mediated	p53-mediated	JJ
cord-280549-bsnz24jx	740	19	apoptosis	apoptosis	NN
cord-280549-bsnz24jx	740	20	T	t	NN
cord-280549-bsnz24jx	740	21	antigen	antigen	NN
cord-280549-bsnz24jx	740	22	is	be	VBZ
cord-280549-bsnz24jx	740	23	bound	bind	VBN
cord-280549-bsnz24jx	740	24	to	to	IN
cord-280549-bsnz24jx	740	25	a	a	DT
cord-280549-bsnz24jx	740	26	host	host	NN
cord-280549-bsnz24jx	740	27	protein	protein	NN
cord-280549-bsnz24jx	740	28	in	in	IN
cord-280549-bsnz24jx	740	29	SV40-transformed	sv40-transformed	CD
cord-280549-bsnz24jx	740	30	cells	cell	NNS
cord-280549-bsnz24jx	740	31	Walleye	Walleye	NNP
cord-280549-bsnz24jx	740	32	retroviruses	retrovirus	NNS
cord-280549-bsnz24jx	740	33	associated	associate	VBN
cord-280549-bsnz24jx	740	34	with	with	IN
cord-280549-bsnz24jx	740	35	skin	skin	NN
cord-280549-bsnz24jx	740	36	tumors	tumor	NNS
cord-280549-bsnz24jx	740	37	and	and	CC
cord-280549-bsnz24jx	740	38	hyperplasias	hyperplasias	NNP
cord-280549-bsnz24jx	740	39	encode	encode	VB
cord-280549-bsnz24jx	740	40	cyclin	cyclin	NN
cord-280549-bsnz24jx	740	41	D	D	NNP
cord-280549-bsnz24jx	740	42	homologs	homologs	NNPS
cord-280549-bsnz24jx	740	43	Association	Association	NNP
cord-280549-bsnz24jx	740	44	of	of	IN
cord-280549-bsnz24jx	740	45	the	the	DT
cord-280549-bsnz24jx	740	46	cyclindependent	cyclindependent	NN
cord-280549-bsnz24jx	740	47	kinases	kinase	NNS
cord-280549-bsnz24jx	740	48	and	and	CC
cord-280549-bsnz24jx	740	49	14	14	CD
cord-280549-bsnz24jx	740	50	-	-	SYM
cord-280549-bsnz24jx	740	51	3	3	CD
cord-280549-bsnz24jx	740	52	-	-	SYM
cord-280549-bsnz24jx	740	53	3	3	CD
cord-280549-bsnz24jx	740	54	sigma	sigma	NNS
cord-280549-bsnz24jx	740	55	negatively	negatively	RB
cord-280549-bsnz24jx	740	56	regulates	regulate	VBZ
cord-280549-bsnz24jx	740	57	cell	cell	NN
cord-280549-bsnz24jx	740	58	cycle	cycle	NN
cord-280549-bsnz24jx	740	59	progression	progression	NN
cord-280549-bsnz24jx	740	60	HIV1	HIV1	NNP
cord-280549-bsnz24jx	740	61	Vpr	Vpr	NNP
cord-280549-bsnz24jx	740	62	arrests	arrest	VBZ
cord-280549-bsnz24jx	740	63	the	the	DT
cord-280549-bsnz24jx	740	64	cell	cell	NN
cord-280549-bsnz24jx	740	65	cycle	cycle	NN
cord-280549-bsnz24jx	740	66	by	by	IN
cord-280549-bsnz24jx	740	67	recruiting	recruit	VBG
cord-280549-bsnz24jx	740	68	DCAF1	DCAF1	NNP
cord-280549-bsnz24jx	740	69	/	/	SYM
cord-280549-bsnz24jx	740	70	VprBP	VprBP	NNP
cord-280549-bsnz24jx	740	71	,	,	,
cord-280549-bsnz24jx	740	72	a	a	DT
cord-280549-bsnz24jx	740	73	receptor	receptor	NN
cord-280549-bsnz24jx	740	74	of	of	IN
cord-280549-bsnz24jx	740	75	the	the	DT
cord-280549-bsnz24jx	740	76	Cul4-DDB1	Cul4-DDB1	NNP
cord-280549-bsnz24jx	740	77	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	740	78	ligase	ligase	NN
cord-280549-bsnz24jx	740	79	Study	Study	NNP
cord-280549-bsnz24jx	740	80	on	on	IN
cord-280549-bsnz24jx	740	81	phylogenetic	phylogenetic	JJ
cord-280549-bsnz24jx	740	82	relationships	relationship	NNS
cord-280549-bsnz24jx	740	83	,	,	,
cord-280549-bsnz24jx	740	84	variability	variability	NN
cord-280549-bsnz24jx	740	85	,	,	,
cord-280549-bsnz24jx	740	86	and	and	CC
cord-280549-bsnz24jx	740	87	correlated	correlate	VBN
cord-280549-bsnz24jx	740	88	mutations	mutation	NNS
cord-280549-bsnz24jx	740	89	in	in	IN
cord-280549-bsnz24jx	740	90	M2	M2	NNP
cord-280549-bsnz24jx	740	91	proteins	protein	NNS
cord-280549-bsnz24jx	740	92	of	of	IN
cord-280549-bsnz24jx	740	93	influenza	influenza	NN
cord-280549-bsnz24jx	740	94	virus	virus	NN
cord-280549-bsnz24jx	741	1	A	a	DT
cord-280549-bsnz24jx	741	2	Simian	simian	JJ
cord-280549-bsnz24jx	741	3	virus	virus	NN
cord-280549-bsnz24jx	741	4	40	40	CD
cord-280549-bsnz24jx	741	5	induces	induce	VBZ
cord-280549-bsnz24jx	741	6	multiple	multiple	JJ
cord-280549-bsnz24jx	741	7	S	S	NNP
cord-280549-bsnz24jx	741	8	phases	phase	NNS
cord-280549-bsnz24jx	741	9	with	with	IN
cord-280549-bsnz24jx	741	10	the	the	DT
cord-280549-bsnz24jx	741	11	majority	majority	NN
cord-280549-bsnz24jx	741	12	of	of	IN
cord-280549-bsnz24jx	741	13	viral	viral	JJ
cord-280549-bsnz24jx	741	14	DNA	dna	NN
cord-280549-bsnz24jx	741	15	replication	replication	NN
cord-280549-bsnz24jx	741	16	in	in	IN
cord-280549-bsnz24jx	741	17	the	the	DT
cord-280549-bsnz24jx	741	18	G2	G2	NNP
cord-280549-bsnz24jx	741	19	and	and	CC
cord-280549-bsnz24jx	741	20	second	second	NNP
cord-280549-bsnz24jx	741	21	S	S	NNP
cord-280549-bsnz24jx	741	22	phase	phase	NN
cord-280549-bsnz24jx	741	23	in	in	IN
cord-280549-bsnz24jx	741	24	CV-1	CV-1	NNP
cord-280549-bsnz24jx	741	25	cells	cell	NNS
cord-280549-bsnz24jx	741	26	Hepatitis	Hepatitis	NNP
cord-280549-bsnz24jx	741	27	B	B	NNP
cord-280549-bsnz24jx	741	28	virus	virus	NN
cord-280549-bsnz24jx	741	29	X	x	NN
cord-280549-bsnz24jx	741	30	protein	protein	NN
cord-280549-bsnz24jx	741	31	and	and	CC
cord-280549-bsnz24jx	741	32	simian	simian	JJ
cord-280549-bsnz24jx	741	33	virus	virus	NN
cord-280549-bsnz24jx	742	1	5	5	CD
cord-280549-bsnz24jx	742	2	V	v	NN
cord-280549-bsnz24jx	742	3	protein	protein	NN
cord-280549-bsnz24jx	742	4	exhibit	exhibit	NN
cord-280549-bsnz24jx	742	5	similar	similar	JJ
cord-280549-bsnz24jx	742	6	UV	uv	NN
cord-280549-bsnz24jx	742	7	-	-	HYPH
cord-280549-bsnz24jx	742	8	DDB1	ddb1	NN
cord-280549-bsnz24jx	742	9	binding	bind	VBG
cord-280549-bsnz24jx	742	10	properties	property	NNS
cord-280549-bsnz24jx	742	11	to	to	TO
cord-280549-bsnz24jx	742	12	mediate	mediate	VB
cord-280549-bsnz24jx	742	13	distinct	distinct	JJ
cord-280549-bsnz24jx	742	14	activities	activity	NNS
cord-280549-bsnz24jx	742	15	p53	p53	NN
cord-280549-bsnz24jx	742	16	,	,	,
cord-280549-bsnz24jx	742	17	the	the	DT
cord-280549-bsnz24jx	742	18	cellular	cellular	JJ
cord-280549-bsnz24jx	742	19	gatekeeper	gatekeeper	NN
cord-280549-bsnz24jx	742	20	for	for	IN
cord-280549-bsnz24jx	742	21	growth	growth	NN
cord-280549-bsnz24jx	742	22	and	and	CC
cord-280549-bsnz24jx	742	23	division	division	NN
cord-280549-bsnz24jx	742	24	Isolation	isolation	NN
cord-280549-bsnz24jx	742	25	of	of	IN
cord-280549-bsnz24jx	742	26	three	three	CD
cord-280549-bsnz24jx	742	27	novel	novel	JJ
cord-280549-bsnz24jx	742	28	human	human	JJ
cord-280549-bsnz24jx	742	29	cyclins	cyclin	NNS
cord-280549-bsnz24jx	742	30	by	by	IN
cord-280549-bsnz24jx	742	31	rescue	rescue	NN
cord-280549-bsnz24jx	742	32	of	of	IN
cord-280549-bsnz24jx	742	33	G1	G1	NNP
cord-280549-bsnz24jx	742	34	cyclin	cyclin	NN
cord-280549-bsnz24jx	742	35	(	(	-LRB-
cord-280549-bsnz24jx	742	36	Cln	cln	NN
cord-280549-bsnz24jx	742	37	)	)	-RRB-
cord-280549-bsnz24jx	742	38	function	function	VB
cord-280549-bsnz24jx	742	39	in	in	IN
cord-280549-bsnz24jx	742	40	yeast	yeast	NN
cord-280549-bsnz24jx	742	41	Zika	Zika	NNP
cord-280549-bsnz24jx	742	42	virus	virus	NN
cord-280549-bsnz24jx	742	43	disrupts	disrupt	VBZ
cord-280549-bsnz24jx	742	44	neural	neural	JJ
cord-280549-bsnz24jx	742	45	progenitor	progenitor	NN
cord-280549-bsnz24jx	742	46	development	development	NN
cord-280549-bsnz24jx	742	47	and	and	CC
cord-280549-bsnz24jx	742	48	leads	lead	VBZ
cord-280549-bsnz24jx	742	49	to	to	IN
cord-280549-bsnz24jx	742	50	microcephaly	microcephaly	VB
cord-280549-bsnz24jx	742	51	in	in	IN
cord-280549-bsnz24jx	742	52	mice	mouse	NNS
cord-280549-bsnz24jx	742	53	Cell	Cell	NNP
cord-280549-bsnz24jx	742	54	cycle	cycle	NN
cord-280549-bsnz24jx	742	55	G2	G2	NNP
cord-280549-bsnz24jx	742	56	/	/	SYM
cord-280549-bsnz24jx	742	57	M	M	NNP
cord-280549-bsnz24jx	742	58	arrest	arrest	NN
cord-280549-bsnz24jx	742	59	through	through	IN
cord-280549-bsnz24jx	742	60	an	an	DT
cord-280549-bsnz24jx	742	61	S	S	NNP
cord-280549-bsnz24jx	742	62	phase	phase	NN
cord-280549-bsnz24jx	742	63	-	-	HYPH
cord-280549-bsnz24jx	742	64	dependent	dependent	JJ
cord-280549-bsnz24jx	742	65	mechanism	mechanism	NN
cord-280549-bsnz24jx	742	66	by	by	IN
cord-280549-bsnz24jx	742	67	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	742	68	viral	viral	JJ
cord-280549-bsnz24jx	742	69	protein	protein	NN
cord-280549-bsnz24jx	742	70	R	r	NN
cord-280549-bsnz24jx	742	71	Characterization	characterization	NN
cord-280549-bsnz24jx	742	72	of	of	IN
cord-280549-bsnz24jx	742	73	cytopathic	cytopathic	JJ
cord-280549-bsnz24jx	742	74	factors	factor	NNS
cord-280549-bsnz24jx	742	75	through	through	IN
cord-280549-bsnz24jx	742	76	genome	genome	NN
cord-280549-bsnz24jx	742	77	-	-	HYPH
cord-280549-bsnz24jx	742	78	wide	wide	JJ
cord-280549-bsnz24jx	742	79	analysis	analysis	NN
cord-280549-bsnz24jx	742	80	of	of	IN
cord-280549-bsnz24jx	742	81	the	the	DT
cord-280549-bsnz24jx	742	82	Zika	Zika	NNP
cord-280549-bsnz24jx	742	83	viral	viral	JJ
cord-280549-bsnz24jx	742	84	proteins	protein	NNS
cord-280549-bsnz24jx	742	85	in	in	IN
cord-280549-bsnz24jx	742	86	fission	fission	NN
cord-280549-bsnz24jx	742	87	yeast	yeast	NN
cord-280549-bsnz24jx	742	88	Chk2	Chk2	NNP
cord-280549-bsnz24jx	742	89	is	be	VBZ
cord-280549-bsnz24jx	742	90	required	require	VBN
cord-280549-bsnz24jx	742	91	for	for	IN
cord-280549-bsnz24jx	742	92	HSV-1	HSV-1	NNP
cord-280549-bsnz24jx	742	93	ICP0-mediated	ICP0-mediated	NNP
cord-280549-bsnz24jx	742	94	G2	G2	NNP
cord-280549-bsnz24jx	742	95	/	/	SYM
cord-280549-bsnz24jx	742	96	M	M	NNP
cord-280549-bsnz24jx	742	97	arrest	arrest	NN
cord-280549-bsnz24jx	742	98	and	and	CC
cord-280549-bsnz24jx	742	99	enhancement	enhancement	NN
cord-280549-bsnz24jx	742	100	of	of	IN
cord-280549-bsnz24jx	742	101	virus	virus	NN
cord-280549-bsnz24jx	742	102	growth	growth	NN
cord-280549-bsnz24jx	742	103	DNA	dna	NN
cord-280549-bsnz24jx	742	104	damage	damage	NN
cord-280549-bsnz24jx	742	105	regulates	regulate	VBZ
cord-280549-bsnz24jx	742	106	Chk2	Chk2	NNP
cord-280549-bsnz24jx	742	107	association	association	NN
cord-280549-bsnz24jx	742	108	with	with	IN
cord-280549-bsnz24jx	742	109	chromatin	chromatin	NNP
cord-280549-bsnz24jx	742	110	Regulation	Regulation	NNP
cord-280549-bsnz24jx	742	111	of	of	IN
cord-280549-bsnz24jx	742	112	CHK2	CHK2	NNP
cord-280549-bsnz24jx	742	113	by	by	IN
cord-280549-bsnz24jx	742	114	DNA	dna	NN
cord-280549-bsnz24jx	742	115	-	-	HYPH
cord-280549-bsnz24jx	742	116	dependent	dependent	JJ
cord-280549-bsnz24jx	742	117	protein	protein	NN
cord-280549-bsnz24jx	742	118	kinase	kinase	VBZ
cord-280549-bsnz24jx	742	119	Human	human	JJ
cord-280549-bsnz24jx	742	120	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	742	121	6	6	CD
cord-280549-bsnz24jx	742	122	suppresses	suppress	VBZ
cord-280549-bsnz24jx	742	123	T	t	NN
cord-280549-bsnz24jx	742	124	cell	cell	NN
cord-280549-bsnz24jx	742	125	proliferation	proliferation	NN
cord-280549-bsnz24jx	742	126	through	through	IN
cord-280549-bsnz24jx	742	127	induction	induction	NN
cord-280549-bsnz24jx	742	128	of	of	IN
cord-280549-bsnz24jx	742	129	cell	cell	NN
cord-280549-bsnz24jx	742	130	cycle	cycle	NN
cord-280549-bsnz24jx	742	131	arrest	arrest	NN
cord-280549-bsnz24jx	742	132	in	in	IN
cord-280549-bsnz24jx	742	133	infected	infected	JJ
cord-280549-bsnz24jx	742	134	cells	cell	NNS
cord-280549-bsnz24jx	742	135	in	in	IN
cord-280549-bsnz24jx	742	136	the	the	DT
cord-280549-bsnz24jx	742	137	G2	G2	NNP
cord-280549-bsnz24jx	742	138	/	/	SYM
cord-280549-bsnz24jx	742	139	M	M	NNP
cord-280549-bsnz24jx	742	140	phase	phase	NN
cord-280549-bsnz24jx	743	1	Kaposi	Kaposi	NNP
cord-280549-bsnz24jx	743	2	's	's	POS
cord-280549-bsnz24jx	743	3	sarcoma	sarcoma	NN
cord-280549-bsnz24jx	743	4	-	-	HYPH
cord-280549-bsnz24jx	743	5	associated	associate	VBN
cord-280549-bsnz24jx	743	6	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	743	7	encodes	encode	VBZ
cord-280549-bsnz24jx	743	8	a	a	DT
cord-280549-bsnz24jx	743	9	functional	functional	JJ
cord-280549-bsnz24jx	743	10	cyclin	cyclin	NN
cord-280549-bsnz24jx	743	11	Viruses	virus	NNS
cord-280549-bsnz24jx	743	12	and	and	CC
cord-280549-bsnz24jx	743	13	human	human	JJ
cord-280549-bsnz24jx	743	14	cancer	cancer	NN
cord-280549-bsnz24jx	743	15	Modulation	modulation	NN
cord-280549-bsnz24jx	743	16	of	of	IN
cord-280549-bsnz24jx	743	17	p53	p53	NN
cord-280549-bsnz24jx	743	18	by	by	IN
cord-280549-bsnz24jx	743	19	mitogen	mitogen	NN
cord-280549-bsnz24jx	743	20	-	-	HYPH
cord-280549-bsnz24jx	743	21	activated	activate	VBN
cord-280549-bsnz24jx	743	22	protein	protein	NN
cord-280549-bsnz24jx	743	23	kinase	kinase	NN
cord-280549-bsnz24jx	743	24	pathways	pathway	NNS
cord-280549-bsnz24jx	743	25	and	and	CC
cord-280549-bsnz24jx	743	26	protein	protein	NN
cord-280549-bsnz24jx	743	27	kinase	kinase	NN
cord-280549-bsnz24jx	743	28	C	C	NNP
cord-280549-bsnz24jx	743	29	delta	delta	NN
cord-280549-bsnz24jx	743	30	during	during	IN
cord-280549-bsnz24jx	743	31	avian	avian	JJ
cord-280549-bsnz24jx	743	32	reovirus	reovirus	NNP
cord-280549-bsnz24jx	743	33	S1133-induced	s1133-induce	VBN
cord-280549-bsnz24jx	744	1	apoptosis	apoptosis	NN
cord-280549-bsnz24jx	744	2	Characterization	characterization	NN
cord-280549-bsnz24jx	744	3	of	of	IN
cord-280549-bsnz24jx	744	4	a	a	DT
cord-280549-bsnz24jx	744	5	54	54	CD
cord-280549-bsnz24jx	744	6	K	K	NNP
cord-280549-bsnz24jx	744	7	dalton	dalton	NNP
cord-280549-bsnz24jx	744	8	cellular	cellular	JJ
cord-280549-bsnz24jx	744	9	SV40	SV40	NNP
cord-280549-bsnz24jx	744	10	tumor	tumor	NN
cord-280549-bsnz24jx	744	11	antigen	antigen	NN
cord-280549-bsnz24jx	744	12	present	present	NN
cord-280549-bsnz24jx	744	13	in	in	IN
cord-280549-bsnz24jx	744	14	SV40-transformed	sv40-transformed	CD
cord-280549-bsnz24jx	744	15	cells	cell	NNS
cord-280549-bsnz24jx	744	16	and	and	CC
cord-280549-bsnz24jx	744	17	uninfected	uninfected	JJ
cord-280549-bsnz24jx	744	18	embryonal	embryonal	JJ
cord-280549-bsnz24jx	744	19	carcinoma	carcinoma	NN
cord-280549-bsnz24jx	744	20	cells	cell	NNS
cord-280549-bsnz24jx	745	1	HTLV-	HTLV-	NNP
cord-280549-bsnz24jx	746	1	I	-PRON-	PRP
cord-280549-bsnz24jx	746	2	Tax	tax	VBP
cord-280549-bsnz24jx	746	3	directly	directly	RB
cord-280549-bsnz24jx	746	4	binds	bind	VBZ
cord-280549-bsnz24jx	746	5	the	the	DT
cord-280549-bsnz24jx	746	6	Cdc20-associated	cdc20-associated	JJ
cord-280549-bsnz24jx	746	7	anaphase	anaphase	NN
cord-280549-bsnz24jx	746	8	-	-	HYPH
cord-280549-bsnz24jx	746	9	promoting	promote	VBG
cord-280549-bsnz24jx	746	10	complex	complex	NN
cord-280549-bsnz24jx	746	11	and	and	CC
cord-280549-bsnz24jx	746	12	activates	activate	VBZ
cord-280549-bsnz24jx	746	13	it	-PRON-	PRP
cord-280549-bsnz24jx	746	14	ahead	ahead	RB
cord-280549-bsnz24jx	746	15	of	of	IN
cord-280549-bsnz24jx	746	16	schedule	schedule	NN
cord-280549-bsnz24jx	746	17	Human	Human	NNP
cord-280549-bsnz24jx	746	18	T	T	NNP
cord-280549-bsnz24jx	746	19	-	-	HYPH
cord-280549-bsnz24jx	746	20	lymphotropic	lymphotropic	NNP
cord-280549-bsnz24jx	746	21	virus	virus	NN
cord-280549-bsnz24jx	746	22	type	type	NN
cord-280549-bsnz24jx	746	23	1	1	CD
cord-280549-bsnz24jx	746	24	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	746	25	tax	tax	NN
cord-280549-bsnz24jx	746	26	promotes	promote	VBZ
cord-280549-bsnz24jx	746	27	unscheduled	unscheduled	JJ
cord-280549-bsnz24jx	746	28	degradation	degradation	NN
cord-280549-bsnz24jx	746	29	of	of	IN
cord-280549-bsnz24jx	746	30	Pds1p	pds1p	NN
cord-280549-bsnz24jx	746	31	/	/	SYM
cord-280549-bsnz24jx	746	32	securin	securin	NN
cord-280549-bsnz24jx	746	33	and	and	CC
cord-280549-bsnz24jx	746	34	Clb2p	clb2p	NN
cord-280549-bsnz24jx	746	35	/	/	SYM
cord-280549-bsnz24jx	746	36	cyclin	cyclin	NN
cord-280549-bsnz24jx	746	37	B1	b1	NN
cord-280549-bsnz24jx	746	38	and	and	CC
cord-280549-bsnz24jx	746	39	causes	cause	VBZ
cord-280549-bsnz24jx	746	40	chromosomal	chromosomal	JJ
cord-280549-bsnz24jx	746	41	instability	instability	NN
cord-280549-bsnz24jx	747	1	Zika	Zika	NNP
cord-280549-bsnz24jx	747	2	Virus	Virus	NNP
cord-280549-bsnz24jx	747	3	Envelope	Envelope	NNP
cord-280549-bsnz24jx	747	4	Protein	Protein	NNP
cord-280549-bsnz24jx	747	5	induces	induce	VBZ
cord-280549-bsnz24jx	747	6	G2	G2	NNP
cord-280549-bsnz24jx	747	7	/	/	SYM
cord-280549-bsnz24jx	747	8	M	M	NNP
cord-280549-bsnz24jx	747	9	cell	cell	NN
cord-280549-bsnz24jx	747	10	cycle	cycle	NN
cord-280549-bsnz24jx	747	11	arrest	arrest	NN
cord-280549-bsnz24jx	747	12	and	and	CC
cord-280549-bsnz24jx	747	13	apoptosis	apoptosis	NN
cord-280549-bsnz24jx	747	14	via	via	IN
cord-280549-bsnz24jx	747	15	an	an	DT
cord-280549-bsnz24jx	747	16	intrinsic	intrinsic	JJ
cord-280549-bsnz24jx	747	17	cell	cell	NN
cord-280549-bsnz24jx	747	18	death	death	NN
cord-280549-bsnz24jx	747	19	signaling	signal	VBG
cord-280549-bsnz24jx	747	20	pathway	pathway	NN
cord-280549-bsnz24jx	747	21	in	in	IN
cord-280549-bsnz24jx	747	22	neuroendocrine	neuroendocrine	JJ
cord-280549-bsnz24jx	747	23	PC12	PC12	NNP
cord-280549-bsnz24jx	747	24	cells	cell	NNS
cord-280549-bsnz24jx	747	25	Purification	purification	NN
cord-280549-bsnz24jx	747	26	of	of	IN
cord-280549-bsnz24jx	747	27	maturationpromoting	maturationpromote	VBG
cord-280549-bsnz24jx	747	28	factor	factor	NN
cord-280549-bsnz24jx	747	29	,	,	,
cord-280549-bsnz24jx	747	30	an	an	DT
cord-280549-bsnz24jx	747	31	intracellular	intracellular	JJ
cord-280549-bsnz24jx	747	32	regulator	regulator	NN
cord-280549-bsnz24jx	747	33	of	of	IN
cord-280549-bsnz24jx	747	34	early	early	JJ
cord-280549-bsnz24jx	747	35	mitotic	mitotic	JJ
cord-280549-bsnz24jx	747	36	events	event	NNS
cord-280549-bsnz24jx	747	37	Degradation	degradation	NN
cord-280549-bsnz24jx	747	38	of	of	IN
cord-280549-bsnz24jx	747	39	nucleosome	nucleosome	NN
cord-280549-bsnz24jx	747	40	-	-	HYPH
cord-280549-bsnz24jx	747	41	associated	associate	VBN
cord-280549-bsnz24jx	747	42	centromeric	centromeric	JJ
cord-280549-bsnz24jx	747	43	histone	histone	NN
cord-280549-bsnz24jx	747	44	H3-like	h3-like	IN
cord-280549-bsnz24jx	747	45	protein	protein	NN
cord-280549-bsnz24jx	747	46	CENP	CENP	NNP
cord-280549-bsnz24jx	747	47	-	-	:
cord-280549-bsnz24jx	747	48	A	a	DT
cord-280549-bsnz24jx	747	49	induced	induce	VBN
cord-280549-bsnz24jx	747	50	by	by	IN
cord-280549-bsnz24jx	747	51	herpes	herpes	NNP
cord-280549-bsnz24jx	747	52	simplex	simplex	NNP
cord-280549-bsnz24jx	747	53	virus	virus	NN
cord-280549-bsnz24jx	747	54	type	type	NN
cord-280549-bsnz24jx	747	55	1	1	CD
cord-280549-bsnz24jx	747	56	protein	protein	NN
cord-280549-bsnz24jx	747	57	ICP0	ICP0	NNP
cord-280549-bsnz24jx	747	58	Inactivation	Inactivation	NNP
cord-280549-bsnz24jx	747	59	of	of	IN
cord-280549-bsnz24jx	747	60	the	the	DT
cord-280549-bsnz24jx	747	61	Cdc25	Cdc25	NNP
cord-280549-bsnz24jx	747	62	phosphatase	phosphatase	NN
cord-280549-bsnz24jx	747	63	by	by	IN
cord-280549-bsnz24jx	747	64	the	the	DT
cord-280549-bsnz24jx	747	65	stress	stress	NN
cord-280549-bsnz24jx	747	66	-	-	HYPH
cord-280549-bsnz24jx	747	67	activated	activate	VBN
cord-280549-bsnz24jx	747	68	Srk1	Srk1	NNP
cord-280549-bsnz24jx	747	69	kinase	kinase	NN
cord-280549-bsnz24jx	747	70	in	in	IN
cord-280549-bsnz24jx	747	71	fission	fission	NN
cord-280549-bsnz24jx	747	72	yeast	yeast	NN
cord-280549-bsnz24jx	747	73	Nuclear	nuclear	JJ
cord-280549-bsnz24jx	747	74	localization	localization	NN
cord-280549-bsnz24jx	747	75	of	of	IN
cord-280549-bsnz24jx	747	76	Cdc25	Cdc25	NNP
cord-280549-bsnz24jx	747	77	is	be	VBZ
cord-280549-bsnz24jx	747	78	regulated	regulate	VBN
cord-280549-bsnz24jx	747	79	by	by	IN
cord-280549-bsnz24jx	747	80	DNA	dna	NN
cord-280549-bsnz24jx	747	81	damage	damage	NN
cord-280549-bsnz24jx	747	82	and	and	CC
cord-280549-bsnz24jx	747	83	a	a	DT
cord-280549-bsnz24jx	747	84	14	14	CD
cord-280549-bsnz24jx	747	85	-	-	SYM
cord-280549-bsnz24jx	747	86	3	3	CD
cord-280549-bsnz24jx	747	87	-	-	SYM
cord-280549-bsnz24jx	747	88	3	3	CD
cord-280549-bsnz24jx	747	89	protein	protein	NN
cord-280549-bsnz24jx	747	90	Serine-345	serine-345	NN
cord-280549-bsnz24jx	747	91	is	be	VBZ
cord-280549-bsnz24jx	747	92	required	require	VBN
cord-280549-bsnz24jx	747	93	for	for	IN
cord-280549-bsnz24jx	747	94	Rad3-dependent	rad3-dependent	NN
cord-280549-bsnz24jx	747	95	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	747	96	and	and	CC
cord-280549-bsnz24jx	747	97	function	function	NN
cord-280549-bsnz24jx	747	98	of	of	IN
cord-280549-bsnz24jx	747	99	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	747	100	kinase	kinase	NN
cord-280549-bsnz24jx	747	101	Chk1	Chk1	VBN
cord-280549-bsnz24jx	747	102	in	in	IN
cord-280549-bsnz24jx	747	103	fission	fission	NN
cord-280549-bsnz24jx	747	104	yeast	yeast	NN
cord-280549-bsnz24jx	748	1	Human	human	JJ
cord-280549-bsnz24jx	748	2	T	t	NN
cord-280549-bsnz24jx	748	3	-	-	HYPH
cord-280549-bsnz24jx	748	4	cell	cell	NN
cord-280549-bsnz24jx	748	5	leukemia	leukemia	NN
cord-280549-bsnz24jx	748	6	virus	virus	NN
cord-280549-bsnz24jx	748	7	type	type	NN
cord-280549-bsnz24jx	748	8	1	1	CD
cord-280549-bsnz24jx	748	9	Tax	tax	NN
cord-280549-bsnz24jx	748	10	releases	release	NNS
cord-280549-bsnz24jx	748	11	cell	cell	NN
cord-280549-bsnz24jx	748	12	cycle	cycle	NN
cord-280549-bsnz24jx	748	13	arrest	arrest	NN
cord-280549-bsnz24jx	748	14	induced	induce	VBN
cord-280549-bsnz24jx	748	15	by	by	IN
cord-280549-bsnz24jx	748	16	p16INK4a	p16INK4a	NNP
cord-280549-bsnz24jx	748	17	Cdc2	Cdc2	NNP
cord-280549-bsnz24jx	748	18	kinase	kinase	NN
cord-280549-bsnz24jx	748	19	directly	directly	RB
cord-280549-bsnz24jx	748	20	phosphorylates	phosphorylate	VBZ
cord-280549-bsnz24jx	748	21	the	the	DT
cord-280549-bsnz24jx	748	22	cis	cis	NNP
cord-280549-bsnz24jx	748	23	-	-	HYPH
cord-280549-bsnz24jx	748	24	Golgi	Golgi	NNP
cord-280549-bsnz24jx	748	25	matrix	matrix	NN
cord-280549-bsnz24jx	748	26	protein	protein	NN
cord-280549-bsnz24jx	748	27	GM130	GM130	NNP
cord-280549-bsnz24jx	748	28	and	and	CC
cord-280549-bsnz24jx	748	29	is	be	VBZ
cord-280549-bsnz24jx	748	30	required	require	VBN
cord-280549-bsnz24jx	748	31	for	for	IN
cord-280549-bsnz24jx	748	32	Golgi	Golgi	NNP
cord-280549-bsnz24jx	748	33	fragmentation	fragmentation	NN
cord-280549-bsnz24jx	748	34	in	in	IN
cord-280549-bsnz24jx	748	35	mitosis	mitosis	NN
cord-280549-bsnz24jx	749	1	Human	Human	NNP
cord-280549-bsnz24jx	749	2	TAFII31	TAFII31	NNP
cord-280549-bsnz24jx	749	3	protein	protein	NN
cord-280549-bsnz24jx	749	4	is	be	VBZ
cord-280549-bsnz24jx	749	5	a	a	DT
cord-280549-bsnz24jx	749	6	transcriptional	transcriptional	JJ
cord-280549-bsnz24jx	749	7	coactivator	coactivator	NN
cord-280549-bsnz24jx	749	8	of	of	IN
cord-280549-bsnz24jx	749	9	the	the	DT
cord-280549-bsnz24jx	749	10	p53	p53	NN
cord-280549-bsnz24jx	749	11	protein	protein	NN
cord-280549-bsnz24jx	749	12	Human	Human	NNP
cord-280549-bsnz24jx	749	13	annexin	annexin	NNP
cord-280549-bsnz24jx	749	14	A6	A6	NNP
cord-280549-bsnz24jx	749	15	interacts	interact	VBZ
cord-280549-bsnz24jx	749	16	with	with	IN
cord-280549-bsnz24jx	749	17	influenza	influenza	NN
cord-280549-bsnz24jx	749	18	A	a	DT
cord-280549-bsnz24jx	749	19	virus	virus	NN
cord-280549-bsnz24jx	749	20	M2	m2	NN
cord-280549-bsnz24jx	749	21	protein	protein	NN
cord-280549-bsnz24jx	749	22	and	and	CC
cord-280549-bsnz24jx	749	23	negatively	negatively	RB
cord-280549-bsnz24jx	749	24	modulates	modulate	VBZ
cord-280549-bsnz24jx	749	25	infection	infection	NN
cord-280549-bsnz24jx	749	26	Active	Active	NNP
cord-280549-bsnz24jx	749	27	cdk6	cdk6	NNP
cord-280549-bsnz24jx	749	28	complexes	complex	NNS
cord-280549-bsnz24jx	749	29	are	be	VBP
cord-280549-bsnz24jx	749	30	predominantly	predominantly	RB
cord-280549-bsnz24jx	749	31	nuclear	nuclear	JJ
cord-280549-bsnz24jx	749	32	and	and	CC
cord-280549-bsnz24jx	749	33	represent	represent	VBP
cord-280549-bsnz24jx	749	34	only	only	RB
cord-280549-bsnz24jx	749	35	a	a	DT
cord-280549-bsnz24jx	749	36	minority	minority	NN
cord-280549-bsnz24jx	749	37	of	of	IN
cord-280549-bsnz24jx	749	38	the	the	DT
cord-280549-bsnz24jx	749	39	cdk6	cdk6	NNP
cord-280549-bsnz24jx	749	40	in	in	IN
cord-280549-bsnz24jx	749	41	T	T	NNP
cord-280549-bsnz24jx	749	42	cells	cell	NNS
cord-280549-bsnz24jx	749	43	Hepatitis	Hepatitis	NNP
cord-280549-bsnz24jx	749	44	C	C	NNP
cord-280549-bsnz24jx	749	45	virus	virus	NN
cord-280549-bsnz24jx	749	46	NS5A	ns5a	XX
cord-280549-bsnz24jx	750	1	physically	physically	RB
cord-280549-bsnz24jx	750	2	associates	associate	NNS
cord-280549-bsnz24jx	750	3	with	with	IN
cord-280549-bsnz24jx	750	4	p53	p53	NN
cord-280549-bsnz24jx	750	5	and	and	CC
cord-280549-bsnz24jx	750	6	regulates	regulate	VBZ
cord-280549-bsnz24jx	750	7	p21	p21	NN
cord-280549-bsnz24jx	750	8	/	/	SYM
cord-280549-bsnz24jx	750	9	waf1	waf1	CD
cord-280549-bsnz24jx	750	10	gene	gene	NN
cord-280549-bsnz24jx	750	11	expression	expression	NN
cord-280549-bsnz24jx	750	12	in	in	IN
cord-280549-bsnz24jx	750	13	a	a	DT
cord-280549-bsnz24jx	750	14	p53-dependent	p53-dependent	CD
cord-280549-bsnz24jx	750	15	manner	manner	NN
cord-280549-bsnz24jx	750	16	Inactivation	Inactivation	NNP
cord-280549-bsnz24jx	750	17	of	of	IN
cord-280549-bsnz24jx	750	18	p27Kip1	p27kip1	CD
cord-280549-bsnz24jx	750	19	by	by	IN
cord-280549-bsnz24jx	750	20	the	the	DT
cord-280549-bsnz24jx	750	21	viral	viral	JJ
cord-280549-bsnz24jx	750	22	E1A	E1A	NNP
cord-280549-bsnz24jx	750	23	oncoprotein	oncoprotein	NN
cord-280549-bsnz24jx	750	24	in	in	IN
cord-280549-bsnz24jx	750	25	TGFbetatreated	tgfbetatreate	VBN
cord-280549-bsnz24jx	750	26	cells	cell	NNS
cord-280549-bsnz24jx	750	27	Cyclin	Cyclin	NNP
cord-280549-bsnz24jx	750	28	-	-	HYPH
cord-280549-bsnz24jx	750	29	dependent	dependent	JJ
cord-280549-bsnz24jx	750	30	kinases	kinase	NNS
cord-280549-bsnz24jx	750	31	Mammalian	mammalian	JJ
cord-280549-bsnz24jx	750	32	cells	cell	NNS
cord-280549-bsnz24jx	750	33	cycle	cycle	VBP
cord-280549-bsnz24jx	750	34	without	without	IN
cord-280549-bsnz24jx	751	1	the	the	DT
cord-280549-bsnz24jx	751	2	D	d	NN
cord-280549-bsnz24jx	751	3	-	-	HYPH
cord-280549-bsnz24jx	751	4	type	type	NN
cord-280549-bsnz24jx	751	5	cyclin	cyclin	NN
cord-280549-bsnz24jx	751	6	-	-	HYPH
cord-280549-bsnz24jx	751	7	dependent	dependent	JJ
cord-280549-bsnz24jx	751	8	kinases	kinase	NNS
cord-280549-bsnz24jx	751	9	Cdk4	Cdk4	NNP
cord-280549-bsnz24jx	751	10	and	and	CC
cord-280549-bsnz24jx	751	11	Cdk6	Cdk6	NNP
cord-280549-bsnz24jx	751	12	MAPKAP	MAPKAP	NNP
cord-280549-bsnz24jx	751	13	kinase-2	kinase-2	NNP
cord-280549-bsnz24jx	751	14	is	be	VBZ
cord-280549-bsnz24jx	751	15	a	a	DT
cord-280549-bsnz24jx	751	16	cell	cell	NN
cord-280549-bsnz24jx	751	17	cycle	cycle	NN
cord-280549-bsnz24jx	751	18	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	751	19	kinase	kinase	NN
cord-280549-bsnz24jx	751	20	that	that	WDT
cord-280549-bsnz24jx	751	21	regulates	regulate	VBZ
cord-280549-bsnz24jx	751	22	the	the	DT
cord-280549-bsnz24jx	751	23	G2	G2	NNP
cord-280549-bsnz24jx	751	24	/	/	SYM
cord-280549-bsnz24jx	751	25	M	M	NNP
cord-280549-bsnz24jx	751	26	transition	transition	NN
cord-280549-bsnz24jx	751	27	and	and	CC
cord-280549-bsnz24jx	751	28	S	s	NN
cord-280549-bsnz24jx	751	29	phase	phase	NN
cord-280549-bsnz24jx	751	30	progression	progression	NN
cord-280549-bsnz24jx	751	31	in	in	IN
cord-280549-bsnz24jx	751	32	response	response	NN
cord-280549-bsnz24jx	751	33	to	to	IN
cord-280549-bsnz24jx	751	34	UV	uv	NN
cord-280549-bsnz24jx	751	35	irradiation	irradiation	NN
cord-280549-bsnz24jx	751	36	Modulation	modulation	NN
cord-280549-bsnz24jx	751	37	of	of	IN
cord-280549-bsnz24jx	751	38	p27(Kip1	p27(kip1	NN
cord-280549-bsnz24jx	751	39	)	)	-RRB-
cord-280549-bsnz24jx	751	40	levels	level	NNS
cord-280549-bsnz24jx	751	41	by	by	IN
cord-280549-bsnz24jx	751	42	the	the	DT
cord-280549-bsnz24jx	751	43	cyclin	cyclin	NN
cord-280549-bsnz24jx	751	44	encoded	encode	VBN
cord-280549-bsnz24jx	751	45	by	by	IN
cord-280549-bsnz24jx	751	46	Kaposi	Kaposi	NNP
cord-280549-bsnz24jx	751	47	's	's	POS
cord-280549-bsnz24jx	751	48	sarcoma	sarcoma	NN
cord-280549-bsnz24jx	751	49	-	-	HYPH
cord-280549-bsnz24jx	751	50	associated	associate	VBN
cord-280549-bsnz24jx	751	51	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	752	1	The	the	DT
cord-280549-bsnz24jx	752	2	Epstein	Epstein	NNP
cord-280549-bsnz24jx	752	3	-	-	HYPH
cord-280549-bsnz24jx	752	4	Barr	Barr	NNP
cord-280549-bsnz24jx	752	5	virus	virus	NN
cord-280549-bsnz24jx	752	6	nuclear	nuclear	JJ
cord-280549-bsnz24jx	752	7	protein	protein	NN
cord-280549-bsnz24jx	752	8	encoded	encode	VBN
cord-280549-bsnz24jx	752	9	by	by	IN
cord-280549-bsnz24jx	752	10	the	the	DT
cord-280549-bsnz24jx	752	11	leader	leader	NN
cord-280549-bsnz24jx	752	12	of	of	IN
cord-280549-bsnz24jx	752	13	the	the	DT
cord-280549-bsnz24jx	752	14	EBNA	EBNA	NNP
cord-280549-bsnz24jx	752	15	RNAs	RNAs	NNPS
cord-280549-bsnz24jx	752	16	is	be	VBZ
cord-280549-bsnz24jx	752	17	important	important	JJ
cord-280549-bsnz24jx	752	18	in	in	IN
cord-280549-bsnz24jx	752	19	B	b	NN
cord-280549-bsnz24jx	752	20	-	-	HYPH
cord-280549-bsnz24jx	752	21	lymphocyte	lymphocyte	NN
cord-280549-bsnz24jx	752	22	transformation	transformation	NN
cord-280549-bsnz24jx	753	1	Hepatitis	Hepatitis	NNP
cord-280549-bsnz24jx	753	2	B	B	NNP
cord-280549-bsnz24jx	753	3	virus	virus	NN
cord-280549-bsnz24jx	753	4	X	x	NN
cord-280549-bsnz24jx	753	5	protein	protein	NN
cord-280549-bsnz24jx	753	6	affects	affect	VBZ
cord-280549-bsnz24jx	753	7	S	s	NN
cord-280549-bsnz24jx	753	8	phase	phase	NN
cord-280549-bsnz24jx	753	9	progression	progression	NN
cord-280549-bsnz24jx	753	10	leading	lead	VBG
cord-280549-bsnz24jx	753	11	to	to	IN
cord-280549-bsnz24jx	753	12	chromosome	chromosome	NN
cord-280549-bsnz24jx	753	13	segregation	segregation	NN
cord-280549-bsnz24jx	753	14	defects	defect	NNS
cord-280549-bsnz24jx	753	15	by	by	IN
cord-280549-bsnz24jx	753	16	binding	bind	VBG
cord-280549-bsnz24jx	753	17	to	to	IN
cord-280549-bsnz24jx	753	18	damaged	damage	VBN
cord-280549-bsnz24jx	753	19	DNA	dna	NN
cord-280549-bsnz24jx	753	20	binding	bind	VBG
cord-280549-bsnz24jx	753	21	protein	protein	NN
cord-280549-bsnz24jx	753	22	1	1	CD
cord-280549-bsnz24jx	753	23	Activation	Activation	NNP
cord-280549-bsnz24jx	753	24	of	of	IN
cord-280549-bsnz24jx	753	25	cyclin	cyclin	NN
cord-280549-bsnz24jx	753	26	-	-	HYPH
cord-280549-bsnz24jx	753	27	dependent	dependent	JJ
cord-280549-bsnz24jx	753	28	kinase	kinase	NN
cord-280549-bsnz24jx	753	29	4	4	CD
cord-280549-bsnz24jx	753	30	(	(	-LRB-
cord-280549-bsnz24jx	753	31	cdk4	cdk4	ADD
cord-280549-bsnz24jx	753	32	)	)	-RRB-
cord-280549-bsnz24jx	753	33	by	by	IN
cord-280549-bsnz24jx	753	34	mouse	mouse	NN
cord-280549-bsnz24jx	753	35	MO15-associated	MO15-associated	NNP
cord-280549-bsnz24jx	753	36	kinase	kinase	NN
cord-280549-bsnz24jx	753	37	Linkage	Linkage	NNP
cord-280549-bsnz24jx	753	38	of	of	IN
cord-280549-bsnz24jx	753	39	ATM	atm	NN
cord-280549-bsnz24jx	753	40	to	to	IN
cord-280549-bsnz24jx	753	41	cell	cell	NN
cord-280549-bsnz24jx	753	42	cycle	cycle	NN
cord-280549-bsnz24jx	753	43	regulation	regulation	NN
cord-280549-bsnz24jx	753	44	by	by	IN
cord-280549-bsnz24jx	753	45	the	the	DT
cord-280549-bsnz24jx	753	46	Chk2	Chk2	NNP
cord-280549-bsnz24jx	753	47	protein	protein	NN
cord-280549-bsnz24jx	753	48	kinase	kinase	NN
cord-280549-bsnz24jx	753	49	D	d	NN
cord-280549-bsnz24jx	753	50	-	-	HYPH
cord-280549-bsnz24jx	753	51	type	type	NN
cord-280549-bsnz24jx	753	52	cyclin	cyclin	NN
cord-280549-bsnz24jx	753	53	-	-	HYPH
cord-280549-bsnz24jx	753	54	dependent	dependent	JJ
cord-280549-bsnz24jx	753	55	kinase	kinase	NN
cord-280549-bsnz24jx	753	56	activity	activity	NN
cord-280549-bsnz24jx	753	57	in	in	IN
cord-280549-bsnz24jx	753	58	mammalian	mammalian	JJ
cord-280549-bsnz24jx	753	59	cells	cell	NNS
cord-280549-bsnz24jx	754	1	The	the	DT
cord-280549-bsnz24jx	754	2	PTEN	PTEN	NNP
cord-280549-bsnz24jx	754	3	,	,	,
cord-280549-bsnz24jx	754	4	Mdm2	Mdm2	NNP
cord-280549-bsnz24jx	754	5	,	,	,
cord-280549-bsnz24jx	754	6	p53	p53	NN
cord-280549-bsnz24jx	754	7	tumor	tumor	NN
cord-280549-bsnz24jx	754	8	suppressor	suppressor	NN
cord-280549-bsnz24jx	754	9	-	-	HYPH
cord-280549-bsnz24jx	754	10	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	754	11	network	network	NN
cord-280549-bsnz24jx	754	12	Human	Human	NNP
cord-280549-bsnz24jx	754	13	Wee1	Wee1	NNP
cord-280549-bsnz24jx	754	14	kinase	kinase	NN
cord-280549-bsnz24jx	754	15	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	754	16	cell	cell	NN
cord-280549-bsnz24jx	754	17	division	division	NN
cord-280549-bsnz24jx	754	18	by	by	IN
cord-280549-bsnz24jx	754	19	phosphorylating	phosphorylate	VBG
cord-280549-bsnz24jx	754	20	p34cdc2	p34cdc2	NNP
cord-280549-bsnz24jx	754	21	exclusively	exclusively	RB
cord-280549-bsnz24jx	754	22	on	on	IN
cord-280549-bsnz24jx	754	23	Tyr15	Tyr15	NNP
cord-280549-bsnz24jx	754	24	Human	Human	NNP
cord-280549-bsnz24jx	754	25	viral	viral	JJ
cord-280549-bsnz24jx	754	26	oncogenesis	oncogenesis	NN
cord-280549-bsnz24jx	754	27	:	:	:
cord-280549-bsnz24jx	754	28	a	a	DT
cord-280549-bsnz24jx	754	29	cancer	cancer	NN
cord-280549-bsnz24jx	754	30	hallmarks	hallmarks	NNP
cord-280549-bsnz24jx	754	31	analysis	analysis	NN
cord-280549-bsnz24jx	755	1	The	the	DT
cord-280549-bsnz24jx	755	2	transcriptional	transcriptional	JJ
cord-280549-bsnz24jx	755	3	transactivation	transactivation	NN
cord-280549-bsnz24jx	755	4	function	function	NN
cord-280549-bsnz24jx	755	5	of	of	IN
cord-280549-bsnz24jx	755	6	wild	wild	JJ
cord-280549-bsnz24jx	755	7	-	-	HYPH
cord-280549-bsnz24jx	755	8	type	type	NN
cord-280549-bsnz24jx	755	9	-	-	HYPH
cord-280549-bsnz24jx	755	10	p53	p53	NN
cord-280549-bsnz24jx	755	11	is	be	VBZ
cord-280549-bsnz24jx	755	12	inhibited	inhibit	VBN
cord-280549-bsnz24jx	755	13	by	by	IN
cord-280549-bsnz24jx	755	14	SV40	SV40	NNP
cord-280549-bsnz24jx	755	15	large	large	JJ
cord-280549-bsnz24jx	755	16	T	t	NN
cord-280549-bsnz24jx	755	17	-	-	HYPH
cord-280549-bsnz24jx	755	18	antigen	antigen	NN
cord-280549-bsnz24jx	755	19	and	and	CC
cord-280549-bsnz24jx	755	20	by	by	IN
cord-280549-bsnz24jx	755	21	Hpv-16	Hpv-16	NNP
cord-280549-bsnz24jx	755	22	E6-oncoprotein	E6-oncoprotein	NNP
cord-280549-bsnz24jx	756	1	The	the	DT
cord-280549-bsnz24jx	756	2	cdc25	cdc25	CD
cord-280549-bsnz24jx	756	3	M	M	NNP
cord-280549-bsnz24jx	756	4	-	-	HYPH
cord-280549-bsnz24jx	756	5	phase	phase	NN
cord-280549-bsnz24jx	756	6	inducer	inducer	NN
cord-280549-bsnz24jx	756	7	:	:	:
cord-280549-bsnz24jx	756	8	an	an	DT
cord-280549-bsnz24jx	756	9	unconventional	unconventional	JJ
cord-280549-bsnz24jx	756	10	protein	protein	NN
cord-280549-bsnz24jx	756	11	phosphatase	phosphatase	NN
cord-280549-bsnz24jx	756	12	Human	Human	NNP
cord-280549-bsnz24jx	756	13	survivin	survivin	NN
cord-280549-bsnz24jx	756	14	is	be	VBZ
cord-280549-bsnz24jx	756	15	negatively	negatively	RB
cord-280549-bsnz24jx	756	16	regulated	regulate	VBN
cord-280549-bsnz24jx	756	17	by	by	IN
cord-280549-bsnz24jx	756	18	wild	wild	JJ
cord-280549-bsnz24jx	756	19	-	-	HYPH
cord-280549-bsnz24jx	756	20	type	type	NN
cord-280549-bsnz24jx	756	21	p53	p53	NN
cord-280549-bsnz24jx	756	22	and	and	CC
cord-280549-bsnz24jx	756	23	participates	participate	VBZ
cord-280549-bsnz24jx	756	24	in	in	IN
cord-280549-bsnz24jx	756	25	p53-dependent	p53-dependent	DT
cord-280549-bsnz24jx	756	26	apoptotic	apoptotic	JJ
cord-280549-bsnz24jx	756	27	pathway	pathway	NN
cord-280549-bsnz24jx	756	28	Dual	dual	JJ
cord-280549-bsnz24jx	756	29	regulation	regulation	NN
cord-280549-bsnz24jx	756	30	of	of	IN
cord-280549-bsnz24jx	756	31	the	the	DT
cord-280549-bsnz24jx	756	32	anaphase	anaphase	NN
cord-280549-bsnz24jx	756	33	promoting	promote	VBG
cord-280549-bsnz24jx	756	34	complex	complex	NN
cord-280549-bsnz24jx	756	35	in	in	IN
cord-280549-bsnz24jx	756	36	human	human	JJ
cord-280549-bsnz24jx	756	37	cells	cell	NNS
cord-280549-bsnz24jx	756	38	by	by	IN
cord-280549-bsnz24jx	756	39	cyclin	cyclin	NNP
cord-280549-bsnz24jx	756	40	A	A	NNP
cord-280549-bsnz24jx	756	41	-	-	HYPH
cord-280549-bsnz24jx	756	42	Cdk2	Cdk2	NNP
cord-280549-bsnz24jx	756	43	and	and	CC
cord-280549-bsnz24jx	756	44	cyclin	cyclin	VB
cord-280549-bsnz24jx	756	45	A	A	NNP
cord-280549-bsnz24jx	756	46	-	-	HYPH
cord-280549-bsnz24jx	756	47	Cdk1	Cdk1	NNP
cord-280549-bsnz24jx	756	48	complexes	complex	NNS
cord-280549-bsnz24jx	756	49	Human	human	JJ
cord-280549-bsnz24jx	756	50	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	756	51	6A	6a	CD
cord-280549-bsnz24jx	756	52	(	(	-LRB-
cord-280549-bsnz24jx	756	53	HHV-6A	HHV-6A	NNP
cord-280549-bsnz24jx	756	54	)	)	-RRB-
cord-280549-bsnz24jx	756	55	and	and	CC
cord-280549-bsnz24jx	757	1	HHV-6B	HHV-6B	NNP
cord-280549-bsnz24jx	757	2	alter	alter	VB
cord-280549-bsnz24jx	757	3	E2F1	E2F1	NNP
cord-280549-bsnz24jx	757	4	/	/	SYM
cord-280549-bsnz24jx	757	5	Rb	Rb	NNP
cord-280549-bsnz24jx	757	6	pathways	pathway	NNS
cord-280549-bsnz24jx	757	7	and	and	CC
cord-280549-bsnz24jx	757	8	E2F1	E2F1	NNP
cord-280549-bsnz24jx	757	9	localization	localization	NN
cord-280549-bsnz24jx	757	10	and	and	CC
cord-280549-bsnz24jx	757	11	cause	cause	VB
cord-280549-bsnz24jx	757	12	cell	cell	NN
cord-280549-bsnz24jx	757	13	cycle	cycle	NN
cord-280549-bsnz24jx	757	14	arrest	arrest	NN
cord-280549-bsnz24jx	757	15	in	in	IN
cord-280549-bsnz24jx	757	16	infected	infected	JJ
cord-280549-bsnz24jx	757	17	T	t	NN
cord-280549-bsnz24jx	757	18	cells	cell	NNS
cord-280549-bsnz24jx	757	19	Cell	cell	NN
cord-280549-bsnz24jx	757	20	cycle	cycle	NN
cord-280549-bsnz24jx	757	21	deregulation	deregulation	NN
cord-280549-bsnz24jx	757	22	by	by	IN
cord-280549-bsnz24jx	757	23	a	a	DT
cord-280549-bsnz24jx	757	24	poxvirus	poxvirus	JJ
cord-280549-bsnz24jx	757	25	partial	partial	JJ
cord-280549-bsnz24jx	757	26	mimic	mimic	NN
cord-280549-bsnz24jx	757	27	of	of	IN
cord-280549-bsnz24jx	757	28	anaphase	anaphase	NN
cord-280549-bsnz24jx	757	29	-	-	HYPH
cord-280549-bsnz24jx	757	30	promoting	promote	VBG
cord-280549-bsnz24jx	757	31	complex	complex	JJ
cord-280549-bsnz24jx	757	32	subunit	subunit	NN
cord-280549-bsnz24jx	757	33	11	11	CD
cord-280549-bsnz24jx	757	34	Disruption	Disruption	NNP
cord-280549-bsnz24jx	757	35	of	of	IN
cord-280549-bsnz24jx	757	36	nuclear	nuclear	JJ
cord-280549-bsnz24jx	757	37	lamin	lamin	NNP
cord-280549-bsnz24jx	757	38	organization	organization	NNP
cord-280549-bsnz24jx	757	39	blocks	block	VBZ
cord-280549-bsnz24jx	757	40	the	the	DT
cord-280549-bsnz24jx	757	41	elongation	elongation	NN
cord-280549-bsnz24jx	757	42	phase	phase	NN
cord-280549-bsnz24jx	757	43	of	of	IN
cord-280549-bsnz24jx	757	44	DNA	dna	NN
cord-280549-bsnz24jx	757	45	replication	replication	NN
cord-280549-bsnz24jx	757	46	MDM2-master	MDM2-master	NNP
cord-280549-bsnz24jx	757	47	regulator	regulator	NN
cord-280549-bsnz24jx	757	48	of	of	IN
cord-280549-bsnz24jx	757	49	the	the	DT
cord-280549-bsnz24jx	757	50	p53	p53	NN
cord-280549-bsnz24jx	757	51	tumor	tumor	NN
cord-280549-bsnz24jx	757	52	suppressor	suppressor	NN
cord-280549-bsnz24jx	757	53	protein	protein	NN
cord-280549-bsnz24jx	757	54	Antiviral	antiviral	JJ
cord-280549-bsnz24jx	757	55	activity	activity	NN
cord-280549-bsnz24jx	757	56	of	of	IN
cord-280549-bsnz24jx	757	57	tumor	tumor	NN
cord-280549-bsnz24jx	757	58	-	-	HYPH
cord-280549-bsnz24jx	757	59	suppressor	suppressor	NN
cord-280549-bsnz24jx	757	60	pathways	pathway	NNS
cord-280549-bsnz24jx	757	61	:	:	:
cord-280549-bsnz24jx	757	62	clues	clue	NNS
cord-280549-bsnz24jx	757	63	from	from	IN
cord-280549-bsnz24jx	757	64	molecular	molecular	JJ
cord-280549-bsnz24jx	757	65	piracy	piracy	NN
cord-280549-bsnz24jx	757	66	by	by	IN
cord-280549-bsnz24jx	757	67	KSHV	KSHV	NNP
cord-280549-bsnz24jx	757	68	Kinetic	Kinetic	NNP
cord-280549-bsnz24jx	757	69	mechanism	mechanism	NN
cord-280549-bsnz24jx	757	70	of	of	IN
cord-280549-bsnz24jx	757	71	activation	activation	NN
cord-280549-bsnz24jx	757	72	of	of	IN
cord-280549-bsnz24jx	757	73	the	the	DT
cord-280549-bsnz24jx	757	74	Cdk2	Cdk2	NNP
cord-280549-bsnz24jx	757	75	/	/	SYM
cord-280549-bsnz24jx	757	76	cyclin	cyclin	NN
cord-280549-bsnz24jx	757	77	A	a	DT
cord-280549-bsnz24jx	757	78	complex	complex	NN
cord-280549-bsnz24jx	757	79	.	.	.
cord-280549-bsnz24jx	758	1	Key	key	JJ
cord-280549-bsnz24jx	758	2	role	role	NN
cord-280549-bsnz24jx	758	3	of	of	IN
cord-280549-bsnz24jx	758	4	the	the	DT
cord-280549-bsnz24jx	758	5	C	c	NN
cord-280549-bsnz24jx	758	6	-	-	HYPH
cord-280549-bsnz24jx	758	7	lobe	lobe	NN
cord-280549-bsnz24jx	758	8	of	of	IN
cord-280549-bsnz24jx	758	9	the	the	DT
cord-280549-bsnz24jx	758	10	Cdk	Cdk	NNP
cord-280549-bsnz24jx	758	11	HBx	hbx	NN
cord-280549-bsnz24jx	758	12	-	-	HYPH
cord-280549-bsnz24jx	758	13	dependent	dependent	JJ
cord-280549-bsnz24jx	758	14	cell	cell	NN
cord-280549-bsnz24jx	758	15	cycle	cycle	NN
cord-280549-bsnz24jx	758	16	deregulation	deregulation	NN
cord-280549-bsnz24jx	758	17	involves	involve	VBZ
cord-280549-bsnz24jx	758	18	interaction	interaction	NN
cord-280549-bsnz24jx	758	19	with	with	IN
cord-280549-bsnz24jx	758	20	cyclin	cyclin	NN
cord-280549-bsnz24jx	758	21	E	E	NNP
cord-280549-bsnz24jx	758	22	/	/	SYM
cord-280549-bsnz24jx	758	23	A	A	NNP
cord-280549-bsnz24jx	758	24	-	-	HYPH
cord-280549-bsnz24jx	758	25	cdk2	cdk2	NNP
cord-280549-bsnz24jx	758	26	complex	complex	NN
cord-280549-bsnz24jx	758	27	and	and	CC
cord-280549-bsnz24jx	758	28	destabilization	destabilization	NN
cord-280549-bsnz24jx	758	29	of	of	IN
cord-280549-bsnz24jx	758	30	p27Kip1	p27kip1	CD
cord-280549-bsnz24jx	758	31	Coordination	Coordination	NNP
cord-280549-bsnz24jx	758	32	of	of	IN
cord-280549-bsnz24jx	758	33	structure	structure	NN
cord-280549-bsnz24jx	758	34	-	-	HYPH
cord-280549-bsnz24jx	758	35	specific	specific	JJ
cord-280549-bsnz24jx	758	36	nucleases	nuclease	NNS
cord-280549-bsnz24jx	758	37	by	by	IN
cord-280549-bsnz24jx	758	38	human	human	JJ
cord-280549-bsnz24jx	758	39	SLX4	SLX4	NNP
cord-280549-bsnz24jx	758	40	/	/	SYM
cord-280549-bsnz24jx	758	41	BTBD12	BTBD12	NNP
cord-280549-bsnz24jx	758	42	is	be	VBZ
cord-280549-bsnz24jx	758	43	required	require	VBN
cord-280549-bsnz24jx	758	44	for	for	IN
cord-280549-bsnz24jx	758	45	DNA	dna	NN
cord-280549-bsnz24jx	758	46	repair	repair	NN
cord-280549-bsnz24jx	758	47	Human	human	NN
cord-280549-bsnz24jx	758	48	cytomegalovirus	cytomegalovirus	NN
cord-280549-bsnz24jx	758	49	mtrII	mtrII	NNP
cord-280549-bsnz24jx	758	50	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	758	51	binds	bind	VBZ
cord-280549-bsnz24jx	758	52	to	to	IN
cord-280549-bsnz24jx	758	53	p53	p53	NN
cord-280549-bsnz24jx	758	54	and	and	CC
cord-280549-bsnz24jx	758	55	down	down	RB
cord-280549-bsnz24jx	758	56	-	-	HYPH
cord-280549-bsnz24jx	758	57	regulates	regulate	VBZ
cord-280549-bsnz24jx	758	58	p53-activated	p53-activated	JJ
cord-280549-bsnz24jx	758	59	transcription	transcription	NN
cord-280549-bsnz24jx	758	60	14	14	CD
cord-280549-bsnz24jx	758	61	-	-	SYM
cord-280549-bsnz24jx	758	62	3	3	CD
cord-280549-bsnz24jx	758	63	-	-	SYM
cord-280549-bsnz24jx	758	64	3	3	CD
cord-280549-bsnz24jx	758	65	proteins	protein	NNS
cord-280549-bsnz24jx	758	66	:	:	:
cord-280549-bsnz24jx	758	67	regulation	regulation	NN
cord-280549-bsnz24jx	758	68	of	of	IN
cord-280549-bsnz24jx	758	69	subcellular	subcellular	JJ
cord-280549-bsnz24jx	758	70	localization	localization	NN
cord-280549-bsnz24jx	758	71	by	by	IN
cord-280549-bsnz24jx	758	72	molecular	molecular	JJ
cord-280549-bsnz24jx	758	73	interference	interference	NN
cord-280549-bsnz24jx	758	74	Skp2-mediated	skp2-mediated	JJ
cord-280549-bsnz24jx	758	75	degradation	degradation	NN
cord-280549-bsnz24jx	758	76	of	of	IN
cord-280549-bsnz24jx	758	77	p27	p27	NN
cord-280549-bsnz24jx	758	78	regulates	regulate	VBZ
cord-280549-bsnz24jx	758	79	progression	progression	NN
cord-280549-bsnz24jx	758	80	into	into	IN
cord-280549-bsnz24jx	758	81	mitosis	mitosis	NN
cord-280549-bsnz24jx	759	1	The	the	DT
cord-280549-bsnz24jx	759	2	conserved	conserved	JJ
cord-280549-bsnz24jx	759	3	UL24	UL24	NNP
cord-280549-bsnz24jx	759	4	family	family	NN
cord-280549-bsnz24jx	759	5	of	of	IN
cord-280549-bsnz24jx	759	6	human	human	JJ
cord-280549-bsnz24jx	759	7	alpha	alpha	NN
cord-280549-bsnz24jx	759	8	,	,	,
cord-280549-bsnz24jx	759	9	beta	beta	NN
cord-280549-bsnz24jx	759	10	and	and	CC
cord-280549-bsnz24jx	759	11	gamma	gamma	NN
cord-280549-bsnz24jx	760	1	herpesviruses	herpesviruses	NNP
cord-280549-bsnz24jx	760	2	induces	induce	VBZ
cord-280549-bsnz24jx	760	3	cell	cell	NN
cord-280549-bsnz24jx	760	4	cycle	cycle	NN
cord-280549-bsnz24jx	760	5	arrest	arrest	NN
cord-280549-bsnz24jx	760	6	and	and	CC
cord-280549-bsnz24jx	760	7	inactivation	inactivation	NN
cord-280549-bsnz24jx	760	8	of	of	IN
cord-280549-bsnz24jx	760	9	the	the	DT
cord-280549-bsnz24jx	760	10	cyclinB	cyclinB	NNP
cord-280549-bsnz24jx	760	11	/	/	SYM
cord-280549-bsnz24jx	760	12	cdc2	cdc2	NNP
cord-280549-bsnz24jx	760	13	complex	complex	NN
cord-280549-bsnz24jx	760	14	Murine	Murine	NNP
cord-280549-bsnz24jx	760	15	gammaherpesvirus	gammaherpesvirus	NNP
cord-280549-bsnz24jx	760	16	68	68	CD
cord-280549-bsnz24jx	760	17	ORF20	ORF20	NNP
cord-280549-bsnz24jx	760	18	induces	induce	VBZ
cord-280549-bsnz24jx	760	19	cell	cell	NN
cord-280549-bsnz24jx	760	20	-	-	HYPH
cord-280549-bsnz24jx	760	21	cycle	cycle	NN
cord-280549-bsnz24jx	760	22	arrest	arrest	NN
cord-280549-bsnz24jx	760	23	in	in	IN
cord-280549-bsnz24jx	760	24	G(2	G(2	NNP
cord-280549-bsnz24jx	760	25	)	)	-RRB-
cord-280549-bsnz24jx	760	26	by	by	IN
cord-280549-bsnz24jx	760	27	inhibiting	inhibit	VBG
cord-280549-bsnz24jx	760	28	the	the	DT
cord-280549-bsnz24jx	760	29	Cdc2-cyclin	cdc2-cyclin	NN
cord-280549-bsnz24jx	760	30	B	b	NN
cord-280549-bsnz24jx	760	31	complex	complex	JJ
cord-280549-bsnz24jx	760	32	Splitting	split	VBG
cord-280549-bsnz24jx	760	33	the	the	DT
cord-280549-bsnz24jx	760	34	chromosome	chromosome	NN
cord-280549-bsnz24jx	760	35	:	:	:
cord-280549-bsnz24jx	760	36	cutting	cut	VBG
cord-280549-bsnz24jx	760	37	the	the	DT
cord-280549-bsnz24jx	760	38	ties	tie	NNS
cord-280549-bsnz24jx	760	39	that	that	WDT
cord-280549-bsnz24jx	760	40	bind	bind	VBP
cord-280549-bsnz24jx	760	41	sister	sister	NN
cord-280549-bsnz24jx	760	42	chromatids	chromatid	VBZ
cord-280549-bsnz24jx	760	43	Human	Human	NNP
cord-280549-bsnz24jx	760	44	T	T	NNP
cord-280549-bsnz24jx	760	45	-	-	HYPH
cord-280549-bsnz24jx	760	46	cell	cell	NN
cord-280549-bsnz24jx	760	47	leukemia	leukemia	NN
cord-280549-bsnz24jx	760	48	virus	virus	NN
cord-280549-bsnz24jx	760	49	type	type	NN
cord-280549-bsnz24jx	760	50	1	1	CD
cord-280549-bsnz24jx	760	51	Tax	tax	NN
cord-280549-bsnz24jx	760	52	and	and	CC
cord-280549-bsnz24jx	760	53	cell	cell	NN
cord-280549-bsnz24jx	760	54	cycle	cycle	NN
cord-280549-bsnz24jx	760	55	progression	progression	NN
cord-280549-bsnz24jx	760	56	:	:	:
cord-280549-bsnz24jx	760	57	role	role	NN
cord-280549-bsnz24jx	760	58	of	of	IN
cord-280549-bsnz24jx	760	59	cyclin	cyclin	NNP
cord-280549-bsnz24jx	760	60	D	D	NNP
cord-280549-bsnz24jx	760	61	-	-	HYPH
cord-280549-bsnz24jx	760	62	cdk	cdk	NNP
cord-280549-bsnz24jx	760	63	and	and	CC
cord-280549-bsnz24jx	760	64	p110Rb	p110rb	NN
cord-280549-bsnz24jx	760	65	Herpesvirus	Herpesvirus	NNP
cord-280549-bsnz24jx	760	66	saimiri	saimiri	NNP
cord-280549-bsnz24jx	760	67	encodes	encode	VBZ
cord-280549-bsnz24jx	760	68	homologues	homologue	NNS
cord-280549-bsnz24jx	760	69	of	of	IN
cord-280549-bsnz24jx	760	70	G	g	NN
cord-280549-bsnz24jx	760	71	protein	protein	NN
cord-280549-bsnz24jx	760	72	-	-	HYPH
cord-280549-bsnz24jx	760	73	coupled	couple	VBN
cord-280549-bsnz24jx	760	74	receptors	receptor	NNS
cord-280549-bsnz24jx	760	75	and	and	CC
cord-280549-bsnz24jx	760	76	cyclins	cyclin	NNS
cord-280549-bsnz24jx	760	77	Cyclin	Cyclin	NNP
cord-280549-bsnz24jx	760	78	-	-	HYPH
cord-280549-bsnz24jx	760	79	dependent	dependent	JJ
cord-280549-bsnz24jx	760	80	protein	protein	NN
cord-280549-bsnz24jx	760	81	kinases	kinase	NNS
cord-280549-bsnz24jx	760	82	:	:	:
cord-280549-bsnz24jx	760	83	key	key	JJ
cord-280549-bsnz24jx	760	84	regulators	regulator	NNS
cord-280549-bsnz24jx	760	85	of	of	IN
cord-280549-bsnz24jx	760	86	the	the	DT
cord-280549-bsnz24jx	760	87	eukaryotic	eukaryotic	JJ
cord-280549-bsnz24jx	760	88	cell	cell	NN
cord-280549-bsnz24jx	760	89	cycle	cycle	NN
cord-280549-bsnz24jx	760	90	Regulatory	regulatory	JJ
cord-280549-bsnz24jx	760	91	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	760	92	of	of	IN
cord-280549-bsnz24jx	760	93	the	the	DT
cord-280549-bsnz24jx	760	94	p34cdc2	p34cdc2	NNP
cord-280549-bsnz24jx	760	95	protein	protein	NN
cord-280549-bsnz24jx	760	96	kinase	kinase	NN
cord-280549-bsnz24jx	760	97	in	in	IN
cord-280549-bsnz24jx	760	98	vertebrates	vertebrate	NNS
cord-280549-bsnz24jx	761	1	Universal	universal	JJ
cord-280549-bsnz24jx	761	2	control	control	NN
cord-280549-bsnz24jx	761	3	mechanism	mechanism	NN
cord-280549-bsnz24jx	761	4	regulating	regulate	VBG
cord-280549-bsnz24jx	761	5	onset	onset	NN
cord-280549-bsnz24jx	761	6	of	of	IN
cord-280549-bsnz24jx	761	7	M	M	NNP
cord-280549-bsnz24jx	761	8	-	-	HYPH
cord-280549-bsnz24jx	761	9	phase	phase	NN
cord-280549-bsnz24jx	761	10	Regulation	regulation	NN
cord-280549-bsnz24jx	761	11	of	of	IN
cord-280549-bsnz24jx	761	12	the	the	DT
cord-280549-bsnz24jx	761	13	cyclin	cyclin	NN
cord-280549-bsnz24jx	761	14	E	e	NN
cord-280549-bsnz24jx	761	15	gene	gene	NN
cord-280549-bsnz24jx	761	16	by	by	IN
cord-280549-bsnz24jx	761	17	transcription	transcription	NN
cord-280549-bsnz24jx	761	18	factor	factor	NN
cord-280549-bsnz24jx	761	19	E2F1	E2F1	NNP
cord-280549-bsnz24jx	761	20	Evaluation	Evaluation	NNP
cord-280549-bsnz24jx	761	21	of	of	IN
cord-280549-bsnz24jx	761	22	different	different	JJ
cord-280549-bsnz24jx	761	23	clinical	clinical	JJ
cord-280549-bsnz24jx	761	24	sample	sample	NN
cord-280549-bsnz24jx	761	25	types	type	NNS
cord-280549-bsnz24jx	761	26	in	in	IN
cord-280549-bsnz24jx	761	27	diagnosis	diagnosis	NN
cord-280549-bsnz24jx	761	28	of	of	IN
cord-280549-bsnz24jx	761	29	human	human	JJ
cord-280549-bsnz24jx	761	30	enterovirus	enterovirus	NN
cord-280549-bsnz24jx	761	31	71-associated	71-associated	CD
cord-280549-bsnz24jx	761	32	hand	hand	NN
cord-280549-bsnz24jx	761	33	-	-	HYPH
cord-280549-bsnz24jx	761	34	foot	foot	NN
cord-280549-bsnz24jx	761	35	-	-	HYPH
cord-280549-bsnz24jx	761	36	and	and	CC
cord-280549-bsnz24jx	761	37	-	-	HYPH
cord-280549-bsnz24jx	761	38	mouth	mouth	NN
cord-280549-bsnz24jx	761	39	disease	disease	NN
cord-280549-bsnz24jx	762	1	The	the	DT
cord-280549-bsnz24jx	762	2	nonstructural	nonstructural	JJ
cord-280549-bsnz24jx	762	3	proteins	protein	NNS
cord-280549-bsnz24jx	762	4	of	of	IN
cord-280549-bsnz24jx	762	5	the	the	DT
cord-280549-bsnz24jx	762	6	autonomous	autonomous	JJ
cord-280549-bsnz24jx	762	7	parvovirus	parvovirus	NN
cord-280549-bsnz24jx	762	8	minute	minute	NN
cord-280549-bsnz24jx	762	9	virus	virus	NN
cord-280549-bsnz24jx	762	10	of	of	IN
cord-280549-bsnz24jx	762	11	mice	mouse	NNS
cord-280549-bsnz24jx	762	12	interfere	interfere	VBP
cord-280549-bsnz24jx	762	13	with	with	IN
cord-280549-bsnz24jx	762	14	the	the	DT
cord-280549-bsnz24jx	762	15	cell	cell	NN
cord-280549-bsnz24jx	762	16	cycle	cycle	NN
cord-280549-bsnz24jx	762	17	,	,	,
cord-280549-bsnz24jx	762	18	inducing	induce	VBG
cord-280549-bsnz24jx	762	19	accumulation	accumulation	NN
cord-280549-bsnz24jx	762	20	in	in	IN
cord-280549-bsnz24jx	762	21	G2	G2	NNP
cord-280549-bsnz24jx	762	22	The	the	DT
cord-280549-bsnz24jx	762	23	NS1	NS1	NNP
cord-280549-bsnz24jx	762	24	protein	protein	NN
cord-280549-bsnz24jx	762	25	of	of	IN
cord-280549-bsnz24jx	762	26	the	the	DT
cord-280549-bsnz24jx	762	27	autonomous	autonomous	JJ
cord-280549-bsnz24jx	762	28	parvovirus	parvovirus	NN
cord-280549-bsnz24jx	762	29	minute	minute	NN
cord-280549-bsnz24jx	762	30	virus	virus	NN
cord-280549-bsnz24jx	762	31	of	of	IN
cord-280549-bsnz24jx	762	32	mice	mouse	NNS
cord-280549-bsnz24jx	762	33	blocks	block	VBZ
cord-280549-bsnz24jx	762	34	cellular	cellular	JJ
cord-280549-bsnz24jx	762	35	DNA	dna	NN
cord-280549-bsnz24jx	762	36	replication	replication	NN
cord-280549-bsnz24jx	762	37	:	:	:
cord-280549-bsnz24jx	763	1	a	a	DT
cord-280549-bsnz24jx	763	2	consequence	consequence	NN
cord-280549-bsnz24jx	763	3	of	of	IN
cord-280549-bsnz24jx	763	4	lesions	lesion	NNS
cord-280549-bsnz24jx	763	5	to	to	IN
cord-280549-bsnz24jx	763	6	the	the	DT
cord-280549-bsnz24jx	763	7	chromatin	chromatin	NN
cord-280549-bsnz24jx	763	8	?	?	.
cord-280549-bsnz24jx	764	1	Identification	identification	NN
cord-280549-bsnz24jx	764	2	of	of	IN
cord-280549-bsnz24jx	764	3	a	a	DT
cord-280549-bsnz24jx	764	4	viral	viral	JJ
cord-280549-bsnz24jx	764	5	kinase	kinase	NN
cord-280549-bsnz24jx	764	6	that	that	WDT
cord-280549-bsnz24jx	764	7	phosphorylates	phosphorylate	VBZ
cord-280549-bsnz24jx	764	8	specific	specific	JJ
cord-280549-bsnz24jx	764	9	E2Fs	E2Fs	NNP
cord-280549-bsnz24jx	764	10	and	and	CC
cord-280549-bsnz24jx	764	11	pocket	pocket	NN
cord-280549-bsnz24jx	764	12	proteins	protein	NNS
cord-280549-bsnz24jx	765	1	A	a	DT
cord-280549-bsnz24jx	765	2	restriction	restriction	NN
cord-280549-bsnz24jx	765	3	point	point	NN
cord-280549-bsnz24jx	765	4	for	for	IN
cord-280549-bsnz24jx	765	5	control	control	NN
cord-280549-bsnz24jx	765	6	of	of	IN
cord-280549-bsnz24jx	765	7	normal	normal	JJ
cord-280549-bsnz24jx	765	8	animal	animal	NN
cord-280549-bsnz24jx	765	9	cell	cell	NN
cord-280549-bsnz24jx	765	10	proliferation	proliferation	NN
cord-280549-bsnz24jx	765	11	Human	Human	NNP
cord-280549-bsnz24jx	765	12	Tcell	Tcell	NNP
cord-280549-bsnz24jx	765	13	leukemia	leukemia	NN
cord-280549-bsnz24jx	765	14	virus	virus	NN
cord-280549-bsnz24jx	765	15	type	type	NN
cord-280549-bsnz24jx	765	16	1	1	CD
cord-280549-bsnz24jx	765	17	Tax	tax	NN
cord-280549-bsnz24jx	765	18	interacts	interact	VBZ
cord-280549-bsnz24jx	765	19	with	with	IN
cord-280549-bsnz24jx	765	20	Chk1	Chk1	NNP
cord-280549-bsnz24jx	765	21	and	and	CC
cord-280549-bsnz24jx	765	22	attenuates	attenuate	VBZ
cord-280549-bsnz24jx	765	23	DNAdamage	dnadamage	NN
cord-280549-bsnz24jx	765	24	induced	induce	VBN
cord-280549-bsnz24jx	765	25	G2	G2	NNP
cord-280549-bsnz24jx	765	26	arrest	arrest	NN
cord-280549-bsnz24jx	765	27	mediated	mediate	VBN
cord-280549-bsnz24jx	765	28	by	by	IN
cord-280549-bsnz24jx	765	29	Chk1	Chk1	NNP
cord-280549-bsnz24jx	765	30	Human	Human	NNP
cord-280549-bsnz24jx	765	31	T	t	NN
cord-280549-bsnz24jx	765	32	-	-	HYPH
cord-280549-bsnz24jx	765	33	cell	cell	NN
cord-280549-bsnz24jx	765	34	leukemia	leukemia	NN
cord-280549-bsnz24jx	765	35	virus	virus	NN
cord-280549-bsnz24jx	765	36	type	type	NN
cord-280549-bsnz24jx	765	37	1	1	CD
cord-280549-bsnz24jx	765	38	Tax	tax	NN
cord-280549-bsnz24jx	765	39	attenuates	attenuate	VBZ
cord-280549-bsnz24jx	765	40	gamma	gamma	NN
cord-280549-bsnz24jx	765	41	-	-	HYPH
cord-280549-bsnz24jx	765	42	irradiation	irradiation	NN
cord-280549-bsnz24jx	765	43	-	-	HYPH
cord-280549-bsnz24jx	765	44	induced	induce	VBN
cord-280549-bsnz24jx	765	45	apoptosis	apoptosis	NN
cord-280549-bsnz24jx	765	46	through	through	IN
cord-280549-bsnz24jx	765	47	physical	physical	JJ
cord-280549-bsnz24jx	765	48	interaction	interaction	NN
cord-280549-bsnz24jx	765	49	with	with	IN
cord-280549-bsnz24jx	765	50	Chk2	Chk2	NNP
cord-280549-bsnz24jx	765	51	Mitotic	Mitotic	NNP
cord-280549-bsnz24jx	765	52	and	and	CC
cord-280549-bsnz24jx	765	53	G2	G2	NNP
cord-280549-bsnz24jx	765	54	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	765	55	control	control	NN
cord-280549-bsnz24jx	765	56	:	:	:
cord-280549-bsnz24jx	765	57	regulation	regulation	NN
cord-280549-bsnz24jx	765	58	of	of	IN
cord-280549-bsnz24jx	765	59	14	14	CD
cord-280549-bsnz24jx	765	60	-	-	SYM
cord-280549-bsnz24jx	765	61	3	3	CD
cord-280549-bsnz24jx	765	62	-	-	SYM
cord-280549-bsnz24jx	765	63	3	3	CD
cord-280549-bsnz24jx	765	64	protein	protein	NN
cord-280549-bsnz24jx	765	65	binding	bind	VBG
cord-280549-bsnz24jx	765	66	by	by	IN
cord-280549-bsnz24jx	765	67	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	765	68	of	of	IN
cord-280549-bsnz24jx	765	69	Cdc25C	cdc25c	NN
cord-280549-bsnz24jx	765	70	on	on	IN
cord-280549-bsnz24jx	765	71	serine-216	serine-216	NNP
cord-280549-bsnz24jx	766	1	The	the	DT
cord-280549-bsnz24jx	766	2	anaphase	anaphase	NN
cord-280549-bsnz24jx	766	3	promoting	promote	VBG
cord-280549-bsnz24jx	766	4	complex	complex	JJ
cord-280549-bsnz24jx	766	5	/	/	SYM
cord-280549-bsnz24jx	766	6	cyclosome	cyclosome	NN
cord-280549-bsnz24jx	766	7	:	:	:
cord-280549-bsnz24jx	766	8	a	a	DT
cord-280549-bsnz24jx	766	9	machine	machine	NN
cord-280549-bsnz24jx	766	10	designed	design	VBN
cord-280549-bsnz24jx	766	11	to	to	TO
cord-280549-bsnz24jx	766	12	destroy	destroy	VB
cord-280549-bsnz24jx	766	13	The	the	DT
cord-280549-bsnz24jx	766	14	crystal	crystal	JJ
cord-280549-bsnz24jx	766	15	structure	structure	NN
cord-280549-bsnz24jx	766	16	of	of	IN
cord-280549-bsnz24jx	766	17	human	human	JJ
cord-280549-bsnz24jx	766	18	cyclin	cyclin	NN
cord-280549-bsnz24jx	766	19	B	B	NNP
cord-280549-bsnz24jx	766	20	Influenza	Influenza	NNP
cord-280549-bsnz24jx	766	21	M2	m2	JJ
cord-280549-bsnz24jx	766	22	proton	proton	NN
cord-280549-bsnz24jx	766	23	channels	channel	NNS
cord-280549-bsnz24jx	767	1	Re	Re	VBG
cord-280549-bsnz24jx	767	2	-	-	JJ
cord-280549-bsnz24jx	767	3	staging	stage	VBG
cord-280549-bsnz24jx	767	4	mitosis	mitosis	NN
cord-280549-bsnz24jx	767	5	:	:	:
cord-280549-bsnz24jx	767	6	a	a	DT
cord-280549-bsnz24jx	767	7	contemporary	contemporary	JJ
cord-280549-bsnz24jx	767	8	view	view	NN
cord-280549-bsnz24jx	767	9	of	of	IN
cord-280549-bsnz24jx	767	10	mitotic	mitotic	JJ
cord-280549-bsnz24jx	767	11	progression	progression	NN
cord-280549-bsnz24jx	768	1	p16INK4a	p16ink4a	CD
cord-280549-bsnz24jx	768	2	loss	loss	NN
cord-280549-bsnz24jx	768	3	and	and	CC
cord-280549-bsnz24jx	768	4	sensitivity	sensitivity	NN
cord-280549-bsnz24jx	768	5	in	in	IN
cord-280549-bsnz24jx	768	6	KSHV	KSHV	NNP
cord-280549-bsnz24jx	768	7	associated	associate	VBD
cord-280549-bsnz24jx	768	8	primary	primary	JJ
cord-280549-bsnz24jx	768	9	effusion	effusion	NN
cord-280549-bsnz24jx	768	10	lymphoma	lymphoma	NN
cord-280549-bsnz24jx	768	11	Reovirus	Reovirus	NNP
cord-280549-bsnz24jx	768	12	-	-	HYPH
cord-280549-bsnz24jx	768	13	induced	induce	VBN
cord-280549-bsnz24jx	768	14	sigma1s	sigma1s	NNP
cord-280549-bsnz24jx	768	15	-	-	HYPH
cord-280549-bsnz24jx	768	16	dependent	dependent	JJ
cord-280549-bsnz24jx	768	17	G(2)/M	G(2)/M	NNP
cord-280549-bsnz24jx	768	18	phase	phase	NN
cord-280549-bsnz24jx	768	19	cell	cell	NN
cord-280549-bsnz24jx	768	20	cycle	cycle	NN
cord-280549-bsnz24jx	768	21	arrest	arrest	NN
cord-280549-bsnz24jx	768	22	is	be	VBZ
cord-280549-bsnz24jx	768	23	associated	associate	VBN
cord-280549-bsnz24jx	768	24	with	with	IN
cord-280549-bsnz24jx	768	25	inhibition	inhibition	NN
cord-280549-bsnz24jx	768	26	of	of	IN
cord-280549-bsnz24jx	768	27	p34(cdc2	p34(cdc2	NNP
cord-280549-bsnz24jx	768	28	)	)	-RRB-
cord-280549-bsnz24jx	769	1	Reovirus	Reovirus	NNP
cord-280549-bsnz24jx	769	2	-	-	HYPH
cord-280549-bsnz24jx	769	3	induced	induce	VBN
cord-280549-bsnz24jx	769	4	G(2)/M	G(2)/M	NNP
cord-280549-bsnz24jx	769	5	cell	cell	NN
cord-280549-bsnz24jx	769	6	cycle	cycle	NN
cord-280549-bsnz24jx	769	7	arrest	arrest	NN
cord-280549-bsnz24jx	769	8	requires	require	VBZ
cord-280549-bsnz24jx	769	9	sigma	sigma	NNP
cord-280549-bsnz24jx	769	10	1s	1	NNS
cord-280549-bsnz24jx	769	11	and	and	CC
cord-280549-bsnz24jx	769	12	occurs	occur	VBZ
cord-280549-bsnz24jx	769	13	in	in	IN
cord-280549-bsnz24jx	769	14	the	the	DT
cord-280549-bsnz24jx	769	15	absence	absence	NN
cord-280549-bsnz24jx	769	16	of	of	IN
cord-280549-bsnz24jx	769	17	apoptosis	apoptosis	NN
cord-280549-bsnz24jx	770	1	The	the	DT
cord-280549-bsnz24jx	770	2	Mediator	Mediator	NNP
cord-280549-bsnz24jx	770	3	complex	complex	NN
cord-280549-bsnz24jx	770	4	and	and	CC
cord-280549-bsnz24jx	770	5	transcription	transcription	NN
cord-280549-bsnz24jx	770	6	regulation	regulation	NN
cord-280549-bsnz24jx	770	7	Role	role	NN
cord-280549-bsnz24jx	770	8	of	of	IN
cord-280549-bsnz24jx	770	9	baculovirus	baculovirus	NNP
cord-280549-bsnz24jx	770	10	IE2	IE2	NNP
cord-280549-bsnz24jx	770	11	and	and	CC
cord-280549-bsnz24jx	770	12	its	-PRON-	PRP$
cord-280549-bsnz24jx	770	13	RING	ring	NN
cord-280549-bsnz24jx	770	14	finger	finger	NN
cord-280549-bsnz24jx	770	15	in	in	IN
cord-280549-bsnz24jx	770	16	cell	cell	NN
cord-280549-bsnz24jx	770	17	cycle	cycle	NN
cord-280549-bsnz24jx	770	18	arrest	arrest	NN
cord-280549-bsnz24jx	770	19	Overexpression	Overexpression	NNP
cord-280549-bsnz24jx	770	20	of	of	IN
cord-280549-bsnz24jx	770	21	mouse	mouse	NN
cord-280549-bsnz24jx	770	22	D	d	NN
cord-280549-bsnz24jx	770	23	-	-	HYPH
cord-280549-bsnz24jx	770	24	type	type	NN
cord-280549-bsnz24jx	770	25	cyclins	cyclin	NNS
cord-280549-bsnz24jx	770	26	accelerates	accelerate	VBZ
cord-280549-bsnz24jx	770	27	G1	G1	NNP
cord-280549-bsnz24jx	770	28	phase	phase	NN
cord-280549-bsnz24jx	770	29	in	in	IN
cord-280549-bsnz24jx	770	30	rodent	rodent	NN
cord-280549-bsnz24jx	770	31	fibroblasts	fibroblast	NNS
cord-280549-bsnz24jx	770	32	Virus	virus	NN
cord-280549-bsnz24jx	770	33	-	-	HYPH
cord-280549-bsnz24jx	770	34	mediated	mediate	VBN
cord-280549-bsnz24jx	770	35	killing	killing	NN
cord-280549-bsnz24jx	770	36	of	of	IN
cord-280549-bsnz24jx	770	37	cells	cell	NNS
cord-280549-bsnz24jx	770	38	that	that	WDT
cord-280549-bsnz24jx	770	39	lack	lack	VBP
cord-280549-bsnz24jx	770	40	p53	p53	NN
cord-280549-bsnz24jx	770	41	activity	activity	NN
cord-280549-bsnz24jx	770	42	Loss	loss	NN
cord-280549-bsnz24jx	770	43	of	of	IN
cord-280549-bsnz24jx	770	44	Cdk4	Cdk4	NNP
cord-280549-bsnz24jx	770	45	expression	expression	NN
cord-280549-bsnz24jx	770	46	causes	cause	VBZ
cord-280549-bsnz24jx	770	47	insulin	insulin	NN
cord-280549-bsnz24jx	770	48	-	-	HYPH
cord-280549-bsnz24jx	770	49	deficient	deficient	JJ
cord-280549-bsnz24jx	770	50	diabetes	diabetes	NN
cord-280549-bsnz24jx	770	51	and	and	CC
cord-280549-bsnz24jx	770	52	Cdk4	Cdk4	NNP
cord-280549-bsnz24jx	770	53	activation	activation	NN
cord-280549-bsnz24jx	770	54	results	result	NNS
cord-280549-bsnz24jx	770	55	in	in	IN
cord-280549-bsnz24jx	770	56	beta	beta	JJ
cord-280549-bsnz24jx	770	57	-	-	HYPH
cord-280549-bsnz24jx	770	58	islet	islet	NN
cord-280549-bsnz24jx	770	59	cell	cell	NN
cord-280549-bsnz24jx	770	60	hyperplasia	hyperplasia	NN
cord-280549-bsnz24jx	770	61	Domains	domain	NNS
cord-280549-bsnz24jx	770	62	of	of	IN
cord-280549-bsnz24jx	770	63	the	the	DT
cord-280549-bsnz24jx	770	64	adenovirus	adenovirus	NN
cord-280549-bsnz24jx	770	65	E1A	e1a	NN
cord-280549-bsnz24jx	770	66	protein	protein	NN
cord-280549-bsnz24jx	770	67	required	require	VBN
cord-280549-bsnz24jx	770	68	for	for	IN
cord-280549-bsnz24jx	770	69	oncogenic	oncogenic	JJ
cord-280549-bsnz24jx	770	70	activity	activity	NN
cord-280549-bsnz24jx	770	71	are	be	VBP
cord-280549-bsnz24jx	770	72	also	also	RB
cord-280549-bsnz24jx	770	73	required	require	VBN
cord-280549-bsnz24jx	770	74	for	for	IN
cord-280549-bsnz24jx	770	75	dissociation	dissociation	NN
cord-280549-bsnz24jx	770	76	of	of	IN
cord-280549-bsnz24jx	770	77	E2F	e2f	NN
cord-280549-bsnz24jx	770	78	transcription	transcription	NN
cord-280549-bsnz24jx	770	79	factor	factor	NN
cord-280549-bsnz24jx	770	80	complexes	complex	NNS
cord-280549-bsnz24jx	771	1	Cyclin	Cyclin	NNP
cord-280549-bsnz24jx	771	2	C	C	NNP
cord-280549-bsnz24jx	771	3	/	/	SYM
cord-280549-bsnz24jx	771	4	cdk3	cdk3	XX
cord-280549-bsnz24jx	771	5	promotes	promote	VBZ
cord-280549-bsnz24jx	771	6	Rb	Rb	NNP
cord-280549-bsnz24jx	771	7	-	-	HYPH
cord-280549-bsnz24jx	771	8	dependent	dependent	JJ
cord-280549-bsnz24jx	771	9	G0	g0	NN
cord-280549-bsnz24jx	771	10	exit	exit	NN
cord-280549-bsnz24jx	771	11	Activation	activation	NN
cord-280549-bsnz24jx	771	12	of	of	IN
cord-280549-bsnz24jx	771	13	the	the	DT
cord-280549-bsnz24jx	771	14	ATR	ATR	NNP
cord-280549-bsnz24jx	771	15	-	-	HYPH
cord-280549-bsnz24jx	771	16	mediated	mediate	VBN
cord-280549-bsnz24jx	771	17	DNA	dna	NN
cord-280549-bsnz24jx	771	18	damage	damage	NN
cord-280549-bsnz24jx	771	19	response	response	NN
cord-280549-bsnz24jx	771	20	by	by	IN
cord-280549-bsnz24jx	771	21	the	the	DT
cord-280549-bsnz24jx	771	22	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	771	23	viral	viral	JJ
cord-280549-bsnz24jx	771	24	protein	protein	NN
cord-280549-bsnz24jx	771	25	R	R	NNP
cord-280549-bsnz24jx	771	26	Dual	dual	JJ
cord-280549-bsnz24jx	771	27	control	control	NN
cord-280549-bsnz24jx	771	28	of	of	IN
cord-280549-bsnz24jx	771	29	myc	myc	NNP
cord-280549-bsnz24jx	771	30	expression	expression	NN
cord-280549-bsnz24jx	771	31	through	through	IN
cord-280549-bsnz24jx	771	32	a	a	DT
cord-280549-bsnz24jx	771	33	single	single	JJ
cord-280549-bsnz24jx	771	34	DNA	dna	NN
cord-280549-bsnz24jx	771	35	binding	binding	NN
cord-280549-bsnz24jx	771	36	site	site	NN
cord-280549-bsnz24jx	771	37	targeted	target	VBN
cord-280549-bsnz24jx	771	38	by	by	IN
cord-280549-bsnz24jx	771	39	ets	ets	NNP
cord-280549-bsnz24jx	771	40	family	family	NN
cord-280549-bsnz24jx	771	41	proteins	protein	NNS
cord-280549-bsnz24jx	771	42	and	and	CC
cord-280549-bsnz24jx	771	43	E2F-1	E2F-1	NNP
cord-280549-bsnz24jx	771	44	Walleye	Walleye	NNP
cord-280549-bsnz24jx	771	45	dermal	dermal	JJ
cord-280549-bsnz24jx	771	46	sarcoma	sarcoma	NN
cord-280549-bsnz24jx	771	47	virus	virus	NN
cord-280549-bsnz24jx	771	48	cyclin	cyclin	NN
cord-280549-bsnz24jx	771	49	interacts	interact	VBZ
cord-280549-bsnz24jx	771	50	with	with	IN
cord-280549-bsnz24jx	771	51	components	component	NNS
cord-280549-bsnz24jx	771	52	of	of	IN
cord-280549-bsnz24jx	771	53	the	the	DT
cord-280549-bsnz24jx	771	54	mediator	mediator	NN
cord-280549-bsnz24jx	771	55	complex	complex	NN
cord-280549-bsnz24jx	771	56	and	and	CC
cord-280549-bsnz24jx	771	57	the	the	DT
cord-280549-bsnz24jx	771	58	RNA	RNA	NNP
cord-280549-bsnz24jx	771	59	polymerase	polymerase	NN
cord-280549-bsnz24jx	771	60	II	II	NNP
cord-280549-bsnz24jx	772	1	holoenzyme	holoenzyme	NNP
cord-280549-bsnz24jx	772	2	Human	Human	NNP
cord-280549-bsnz24jx	772	3	Immunodeficiency	Immunodeficiency	NNP
cord-280549-bsnz24jx	772	4	Virus	Virus	NNP
cord-280549-bsnz24jx	772	5	Type	Type	NNP
cord-280549-bsnz24jx	772	6	1	1	CD
cord-280549-bsnz24jx	772	7	Vif	vif	NN
cord-280549-bsnz24jx	772	8	causes	cause	VBZ
cord-280549-bsnz24jx	772	9	dysfunction	dysfunction	NN
cord-280549-bsnz24jx	772	10	of	of	IN
cord-280549-bsnz24jx	772	11	Cdk1	Cdk1	NNP
cord-280549-bsnz24jx	772	12	and	and	CC
cord-280549-bsnz24jx	772	13	CyclinB1	cyclinb1	RB
cord-280549-bsnz24jx	772	14	:	:	:
cord-280549-bsnz24jx	773	1	implications	implication	NNS
cord-280549-bsnz24jx	773	2	for	for	IN
cord-280549-bsnz24jx	773	3	cell	cell	NN
cord-280549-bsnz24jx	773	4	cycle	cycle	NN
cord-280549-bsnz24jx	773	5	arrest	arrest	NN
cord-280549-bsnz24jx	773	6	Conservation	Conservation	NNP
cord-280549-bsnz24jx	773	7	of	of	IN
cord-280549-bsnz24jx	773	8	the	the	DT
cord-280549-bsnz24jx	773	9	Chk1	Chk1	NNP
cord-280549-bsnz24jx	773	10	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	773	11	pathway	pathway	NN
cord-280549-bsnz24jx	773	12	in	in	IN
cord-280549-bsnz24jx	773	13	mammals	mammal	NNS
cord-280549-bsnz24jx	773	14	:	:	:
cord-280549-bsnz24jx	773	15	linkage	linkage	NN
cord-280549-bsnz24jx	773	16	of	of	IN
cord-280549-bsnz24jx	773	17	DNA	dna	NN
cord-280549-bsnz24jx	773	18	damage	damage	NN
cord-280549-bsnz24jx	773	19	to	to	IN
cord-280549-bsnz24jx	773	20	Cdk	Cdk	NNP
cord-280549-bsnz24jx	773	21	regulation	regulation	NN
cord-280549-bsnz24jx	773	22	through	through	IN
cord-280549-bsnz24jx	773	23	Cdc25	Cdc25	NNP
cord-280549-bsnz24jx	773	24	Cdk1	Cdk1	NNP
cord-280549-bsnz24jx	773	25	is	be	VBZ
cord-280549-bsnz24jx	773	26	sufficient	sufficient	JJ
cord-280549-bsnz24jx	773	27	to	to	TO
cord-280549-bsnz24jx	773	28	drive	drive	VB
cord-280549-bsnz24jx	773	29	the	the	DT
cord-280549-bsnz24jx	773	30	mammalian	mammalian	JJ
cord-280549-bsnz24jx	773	31	cell	cell	NN
cord-280549-bsnz24jx	773	32	cycle	cycle	NN
cord-280549-bsnz24jx	773	33	KSHV	KSHV	NNP
cord-280549-bsnz24jx	773	34	viral	viral	JJ
cord-280549-bsnz24jx	773	35	cyclin	cyclin	NN
cord-280549-bsnz24jx	774	1	inactivates	inactivate	VBZ
cord-280549-bsnz24jx	774	2	p27KIP1	p27kip1	NN
cord-280549-bsnz24jx	774	3	through	through	IN
cord-280549-bsnz24jx	774	4	Ser10	Ser10	NNP
cord-280549-bsnz24jx	774	5	and	and	CC
cord-280549-bsnz24jx	774	6	Thr187	thr187	JJ
cord-280549-bsnz24jx	774	7	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	774	8	in	in	IN
cord-280549-bsnz24jx	774	9	proliferating	proliferate	VBG
cord-280549-bsnz24jx	774	10	primary	primary	JJ
cord-280549-bsnz24jx	774	11	effusion	effusion	NN
cord-280549-bsnz24jx	774	12	lymphomas	lymphoma	NNS
cord-280549-bsnz24jx	775	1	The	the	DT
cord-280549-bsnz24jx	775	2	HBx	HBx	NNP
cord-280549-bsnz24jx	775	3	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	775	4	of	of	IN
cord-280549-bsnz24jx	775	5	hepatitis	hepatitis	NNP
cord-280549-bsnz24jx	775	6	B	B	NNP
cord-280549-bsnz24jx	775	7	virus	virus	NN
cord-280549-bsnz24jx	775	8	deregulates	deregulate	VBZ
cord-280549-bsnz24jx	775	9	the	the	DT
cord-280549-bsnz24jx	775	10	cell	cell	NN
cord-280549-bsnz24jx	775	11	cycle	cycle	NN
cord-280549-bsnz24jx	775	12	by	by	IN
cord-280549-bsnz24jx	775	13	promoting	promote	VBG
cord-280549-bsnz24jx	775	14	the	the	DT
cord-280549-bsnz24jx	775	15	intracellular	intracellular	JJ
cord-280549-bsnz24jx	775	16	accumulation	accumulation	NN
cord-280549-bsnz24jx	775	17	and	and	CC
cord-280549-bsnz24jx	775	18	re	re	NN
cord-280549-bsnz24jx	775	19	-	-	NN
cord-280549-bsnz24jx	775	20	compartmentalization	compartmentalization	NN
cord-280549-bsnz24jx	775	21	of	of	IN
cord-280549-bsnz24jx	775	22	the	the	DT
cord-280549-bsnz24jx	775	23	cellular	cellular	JJ
cord-280549-bsnz24jx	775	24	deubiquitinase	deubiquitinase	NN
cord-280549-bsnz24jx	775	25	USP37	usp37	RB
cord-280549-bsnz24jx	775	26	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	775	27	Vpr	Vpr	NNP
cord-280549-bsnz24jx	775	28	function	function	NN
cord-280549-bsnz24jx	775	29	is	be	VBZ
cord-280549-bsnz24jx	775	30	mediated	mediate	VBN
cord-280549-bsnz24jx	775	31	by	by	IN
cord-280549-bsnz24jx	775	32	interaction	interaction	NN
cord-280549-bsnz24jx	775	33	with	with	IN
cord-280549-bsnz24jx	775	34	the	the	DT
cord-280549-bsnz24jx	775	35	damage	damage	NN
cord-280549-bsnz24jx	775	36	-	-	HYPH
cord-280549-bsnz24jx	775	37	specific	specific	JJ
cord-280549-bsnz24jx	775	38	DNA	dna	NN
cord-280549-bsnz24jx	775	39	-	-	HYPH
cord-280549-bsnz24jx	775	40	binding	bind	VBG
cord-280549-bsnz24jx	775	41	protein	protein	NN
cord-280549-bsnz24jx	775	42	DDB1	DDB1	NNP
cord-280549-bsnz24jx	775	43	Crystal	Crystal	NNP
cord-280549-bsnz24jx	775	44	structure	structure	NN
cord-280549-bsnz24jx	775	45	of	of	IN
cord-280549-bsnz24jx	775	46	a	a	DT
cord-280549-bsnz24jx	775	47	viral	viral	JJ
cord-280549-bsnz24jx	775	48	cyclin	cyclin	NN
cord-280549-bsnz24jx	775	49	,	,	,
cord-280549-bsnz24jx	775	50	a	a	DT
cord-280549-bsnz24jx	775	51	positive	positive	JJ
cord-280549-bsnz24jx	775	52	regulator	regulator	NN
cord-280549-bsnz24jx	775	53	of	of	IN
cord-280549-bsnz24jx	775	54	cyclin	cyclin	NN
cord-280549-bsnz24jx	775	55	-	-	HYPH
cord-280549-bsnz24jx	775	56	dependent	dependent	JJ
cord-280549-bsnz24jx	775	57	kinase	kinase	NN
cord-280549-bsnz24jx	775	58	6	6	CD
cord-280549-bsnz24jx	775	59	Micro	micro	JJ
cord-280549-bsnz24jx	775	60	RNAs	rna	NNS
cord-280549-bsnz24jx	775	61	of	of	IN
cord-280549-bsnz24jx	775	62	Epstein	Epstein	NNP
cord-280549-bsnz24jx	775	63	-	-	HYPH
cord-280549-bsnz24jx	775	64	Barr	Barr	NNP
cord-280549-bsnz24jx	775	65	virus	virus	NN
cord-280549-bsnz24jx	775	66	promote	promote	VBP
cord-280549-bsnz24jx	775	67	cell	cell	NN
cord-280549-bsnz24jx	775	68	cycle	cycle	NN
cord-280549-bsnz24jx	775	69	progression	progression	NN
cord-280549-bsnz24jx	775	70	and	and	CC
cord-280549-bsnz24jx	775	71	prevent	prevent	VB
cord-280549-bsnz24jx	775	72	apoptosis	apoptosis	NN
cord-280549-bsnz24jx	775	73	of	of	IN
cord-280549-bsnz24jx	775	74	primary	primary	JJ
cord-280549-bsnz24jx	775	75	human	human	NN
cord-280549-bsnz24jx	775	76	B	B	NNP
cord-280549-bsnz24jx	775	77	cells	cell	NNS
cord-280549-bsnz24jx	775	78	Human	human	JJ
cord-280549-bsnz24jx	775	79	herpesvirus	herpesvirus	NN
cord-280549-bsnz24jx	775	80	6	6	CD
cord-280549-bsnz24jx	775	81	(	(	-LRB-
cord-280549-bsnz24jx	775	82	HHV-6	HHV-6	NNP
cord-280549-bsnz24jx	775	83	)	)	-RRB-
cord-280549-bsnz24jx	775	84	alters	alter	VBZ
cord-280549-bsnz24jx	775	85	E2F1	E2F1	NNP
cord-280549-bsnz24jx	775	86	/	/	SYM
cord-280549-bsnz24jx	775	87	Rb	Rb	NNP
cord-280549-bsnz24jx	775	88	pathways	pathway	NNS
cord-280549-bsnz24jx	775	89	and	and	CC
cord-280549-bsnz24jx	775	90	utilizes	utilize	VBZ
cord-280549-bsnz24jx	775	91	the	the	DT
cord-280549-bsnz24jx	775	92	E2F1	E2F1	NNP
cord-280549-bsnz24jx	775	93	transcription	transcription	NN
cord-280549-bsnz24jx	775	94	factor	factor	NN
cord-280549-bsnz24jx	775	95	to	to	TO
cord-280549-bsnz24jx	775	96	express	express	VB
cord-280549-bsnz24jx	775	97	viral	viral	JJ
cord-280549-bsnz24jx	775	98	genes	gene	NNS
cord-280549-bsnz24jx	775	99	Nuclear	Nuclear	NNP
cord-280549-bsnz24jx	775	100	-	-	HYPH
cord-280549-bsnz24jx	775	101	localization	localization	NN
cord-280549-bsnz24jx	775	102	is	be	VBZ
cord-280549-bsnz24jx	775	103	essential	essential	JJ
cord-280549-bsnz24jx	775	104	for	for	IN
cord-280549-bsnz24jx	775	105	the	the	DT
cord-280549-bsnz24jx	775	106	activity	activity	NN
cord-280549-bsnz24jx	775	107	of	of	IN
cord-280549-bsnz24jx	775	108	P53	P53	NNP
cord-280549-bsnz24jx	775	109	protein	protein	NN
cord-280549-bsnz24jx	775	110	Mammalian	mammalian	JJ
cord-280549-bsnz24jx	775	111	G1	G1	NNP
cord-280549-bsnz24jx	775	112	cyclins	cyclin	NNS
cord-280549-bsnz24jx	775	113	CDK	CDK	NNP
cord-280549-bsnz24jx	775	114	inhibitors	inhibitor	NNS
cord-280549-bsnz24jx	775	115	:	:	:
cord-280549-bsnz24jx	775	116	positive	positive	JJ
cord-280549-bsnz24jx	775	117	and	and	CC
cord-280549-bsnz24jx	775	118	negative	negative	JJ
cord-280549-bsnz24jx	775	119	regulators	regulator	NNS
cord-280549-bsnz24jx	775	120	of	of	IN
cord-280549-bsnz24jx	775	121	G1-phase	g1-phase	DT
cord-280549-bsnz24jx	775	122	progression	progression	NN
cord-280549-bsnz24jx	776	1	The	the	DT
cord-280549-bsnz24jx	776	2	human	human	JJ
cord-280549-bsnz24jx	776	3	homologs	homolog	NNS
cord-280549-bsnz24jx	776	4	of	of	IN
cord-280549-bsnz24jx	776	5	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	776	6	kinases	kinase	NNS
cord-280549-bsnz24jx	776	7	Chk1	chk1	VBP
cord-280549-bsnz24jx	776	8	and	and	CC
cord-280549-bsnz24jx	776	9	Cds1	Cds1	''
cord-280549-bsnz24jx	776	10	(	(	-LRB-
cord-280549-bsnz24jx	776	11	Chk2	Chk2	NNP
cord-280549-bsnz24jx	776	12	)	)	-RRB-
cord-280549-bsnz24jx	776	13	phosphorylate	phosphorylate	VBP
cord-280549-bsnz24jx	776	14	p53	p53	NN
cord-280549-bsnz24jx	776	15	at	at	IN
cord-280549-bsnz24jx	776	16	multiple	multiple	JJ
cord-280549-bsnz24jx	776	17	DNA	dna	NN
cord-280549-bsnz24jx	776	18	damage	damage	NN
cord-280549-bsnz24jx	776	19	-	-	HYPH
cord-280549-bsnz24jx	776	20	inducible	inducible	JJ
cord-280549-bsnz24jx	776	21	sites	site	NNS
cord-280549-bsnz24jx	777	1	DNA	dna	NN
cord-280549-bsnz24jx	777	2	damage	damage	NN
cord-280549-bsnz24jx	777	3	-	-	HYPH
cord-280549-bsnz24jx	777	4	induced	induce	VBN
cord-280549-bsnz24jx	777	5	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	777	6	of	of	IN
cord-280549-bsnz24jx	777	7	p53	p53	NN
cord-280549-bsnz24jx	777	8	alleviates	alleviate	VBZ
cord-280549-bsnz24jx	777	9	inhibition	inhibition	NN
cord-280549-bsnz24jx	777	10	by	by	IN
cord-280549-bsnz24jx	777	11	MDM2	MDM2	NNP
cord-280549-bsnz24jx	777	12	Activity	Activity	NNP
cord-280549-bsnz24jx	777	13	of	of	IN
cord-280549-bsnz24jx	777	14	the	the	DT
cord-280549-bsnz24jx	777	15	retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	777	16	family	family	NN
cord-280549-bsnz24jx	777	17	proteins	protein	NNS
cord-280549-bsnz24jx	777	18	,	,	,
cord-280549-bsnz24jx	777	19	pRB	pRB	NNP
cord-280549-bsnz24jx	777	20	,	,	,
cord-280549-bsnz24jx	777	21	p107	p107	NNP
cord-280549-bsnz24jx	777	22	,	,	,
cord-280549-bsnz24jx	777	23	and	and	CC
cord-280549-bsnz24jx	777	24	p130	p130	NNS
cord-280549-bsnz24jx	777	25	,	,	,
cord-280549-bsnz24jx	777	26	during	during	IN
cord-280549-bsnz24jx	777	27	cellular	cellular	JJ
cord-280549-bsnz24jx	777	28	proliferation	proliferation	NN
cord-280549-bsnz24jx	777	29	and	and	CC
cord-280549-bsnz24jx	777	30	differentiation	differentiation	NN
cord-280549-bsnz24jx	777	31	EBNA-2	EBNA-2	NNS
cord-280549-bsnz24jx	777	32	and	and	CC
cord-280549-bsnz24jx	777	33	EBNA	EBNA	NNP
cord-280549-bsnz24jx	777	34	-	-	HYPH
cord-280549-bsnz24jx	777	35	LP	LP	NNP
cord-280549-bsnz24jx	777	36	cooperate	cooperate	VB
cord-280549-bsnz24jx	777	37	to	to	TO
cord-280549-bsnz24jx	777	38	cause	cause	VB
cord-280549-bsnz24jx	777	39	G0	G0	NNP
cord-280549-bsnz24jx	777	40	to	to	IN
cord-280549-bsnz24jx	777	41	G1	G1	NNP
cord-280549-bsnz24jx	777	42	transition	transition	NN
cord-280549-bsnz24jx	777	43	during	during	IN
cord-280549-bsnz24jx	777	44	immortalization	immortalization	NN
cord-280549-bsnz24jx	777	45	of	of	IN
cord-280549-bsnz24jx	777	46	resting	rest	VBG
cord-280549-bsnz24jx	777	47	human	human	JJ
cord-280549-bsnz24jx	777	48	B	b	NN
cord-280549-bsnz24jx	777	49	lymphocytes	lymphocyte	NNS
cord-280549-bsnz24jx	777	50	by	by	IN
cord-280549-bsnz24jx	777	51	Epstein	Epstein	NNP
cord-280549-bsnz24jx	777	52	-	-	HYPH
cord-280549-bsnz24jx	777	53	Barr	Barr	NNP
cord-280549-bsnz24jx	777	54	virus	virus	NN
cord-280549-bsnz24jx	777	55	Human	Human	NNP
cord-280549-bsnz24jx	777	56	cytomegalovirus	cytomegalovirus	NN
cord-280549-bsnz24jx	778	1	mediates	mediate	VBZ
cord-280549-bsnz24jx	778	2	cell	cell	NN
cord-280549-bsnz24jx	778	3	cycle	cycle	NN
cord-280549-bsnz24jx	778	4	progression	progression	NN
cord-280549-bsnz24jx	778	5	through	through	IN
cord-280549-bsnz24jx	778	6	G(1	G(1	NNP
cord-280549-bsnz24jx	778	7	)	)	-RRB-
cord-280549-bsnz24jx	778	8	into	into	IN
cord-280549-bsnz24jx	778	9	early	early	JJ
cord-280549-bsnz24jx	778	10	S	S	NNP
cord-280549-bsnz24jx	778	11	phase	phase	NN
cord-280549-bsnz24jx	778	12	in	in	IN
cord-280549-bsnz24jx	778	13	terminally	terminally	RB
cord-280549-bsnz24jx	778	14	differentiated	differentiate	VBN
cord-280549-bsnz24jx	778	15	cells	cell	NNS
cord-280549-bsnz24jx	778	16	Role	role	NN
cord-280549-bsnz24jx	778	17	of	of	IN
cord-280549-bsnz24jx	778	18	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	778	19	in	in	IN
cord-280549-bsnz24jx	778	20	p34cdc2	p34cdc2	NNP
cord-280549-bsnz24jx	778	21	activation	activation	NN
cord-280549-bsnz24jx	778	22	:	:	:
cord-280549-bsnz24jx	778	23	identification	identification	NN
cord-280549-bsnz24jx	778	24	of	of	IN
cord-280549-bsnz24jx	778	25	an	an	DT
cord-280549-bsnz24jx	778	26	activating	activate	VBG
cord-280549-bsnz24jx	778	27	kinase	kinase	NN
cord-280549-bsnz24jx	778	28	Inhibition	inhibition	NN
cord-280549-bsnz24jx	778	29	of	of	IN
cord-280549-bsnz24jx	778	30	p53-mediated	p53-mediated	JJ
cord-280549-bsnz24jx	778	31	transactivation	transactivation	NN
cord-280549-bsnz24jx	778	32	and	and	CC
cord-280549-bsnz24jx	778	33	cell	cell	NN
cord-280549-bsnz24jx	778	34	cycle	cycle	NN
cord-280549-bsnz24jx	778	35	arrest	arrest	NN
cord-280549-bsnz24jx	778	36	by	by	IN
cord-280549-bsnz24jx	778	37	E1A	E1A	NNP
cord-280549-bsnz24jx	778	38	through	through	IN
cord-280549-bsnz24jx	778	39	its	-PRON-	PRP$
cord-280549-bsnz24jx	778	40	p300	p300	NNP
cord-280549-bsnz24jx	778	41	/	/	SYM
cord-280549-bsnz24jx	778	42	CBPinteracting	cbpinteracting	NN
cord-280549-bsnz24jx	778	43	region	region	NN
cord-280549-bsnz24jx	779	1	The	the	DT
cord-280549-bsnz24jx	779	2	tumour	tumour	NN
cord-280549-bsnz24jx	779	3	suppressor	suppressor	NN
cord-280549-bsnz24jx	779	4	RASSF1A	rassf1a	NN
cord-280549-bsnz24jx	779	5	regulates	regulate	VBZ
cord-280549-bsnz24jx	779	6	mitosis	mitosis	NN
cord-280549-bsnz24jx	779	7	by	by	IN
cord-280549-bsnz24jx	779	8	inhibiting	inhibit	VBG
cord-280549-bsnz24jx	779	9	the	the	DT
cord-280549-bsnz24jx	779	10	APC	APC	NNP
cord-280549-bsnz24jx	779	11	-	-	HYPH
cord-280549-bsnz24jx	779	12	Cdc20	Cdc20	NNP
cord-280549-bsnz24jx	779	13	complex	complex	JJ
cord-280549-bsnz24jx	779	14	Zika	Zika	NNP
cord-280549-bsnz24jx	779	15	virus	virus	NN
cord-280549-bsnz24jx	779	16	infection	infection	NN
cord-280549-bsnz24jx	779	17	induces	induce	VBZ
cord-280549-bsnz24jx	779	18	mitosis	mitosis	NN
cord-280549-bsnz24jx	779	19	abnormalities	abnormality	NNS
cord-280549-bsnz24jx	779	20	and	and	CC
cord-280549-bsnz24jx	779	21	apoptotic	apoptotic	JJ
cord-280549-bsnz24jx	779	22	cell	cell	NN
cord-280549-bsnz24jx	779	23	death	death	NN
cord-280549-bsnz24jx	779	24	of	of	IN
cord-280549-bsnz24jx	779	25	human	human	JJ
cord-280549-bsnz24jx	779	26	neural	neural	JJ
cord-280549-bsnz24jx	779	27	progenitor	progenitor	NN
cord-280549-bsnz24jx	779	28	cells	cell	NNS
cord-280549-bsnz24jx	779	29	Potential	potential	JJ
cord-280549-bsnz24jx	779	30	role	role	NN
cord-280549-bsnz24jx	779	31	of	of	IN
cord-280549-bsnz24jx	779	32	human	human	JJ
cord-280549-bsnz24jx	779	33	cytomegalovirus	cytomegalovirus	NN
cord-280549-bsnz24jx	779	34	and	and	CC
cord-280549-bsnz24jx	779	35	p53	p53	NN
cord-280549-bsnz24jx	779	36	interaction	interaction	NN
cord-280549-bsnz24jx	779	37	in	in	IN
cord-280549-bsnz24jx	779	38	coronary	coronary	JJ
cord-280549-bsnz24jx	779	39	restenosis	restenosis	NN
cord-280549-bsnz24jx	779	40	Regulation	regulation	NN
cord-280549-bsnz24jx	779	41	of	of	IN
cord-280549-bsnz24jx	779	42	PTEN	PTEN	NNP
cord-280549-bsnz24jx	779	43	transcription	transcription	NN
cord-280549-bsnz24jx	779	44	by	by	IN
cord-280549-bsnz24jx	779	45	p53	p53	NN
cord-280549-bsnz24jx	779	46	Microtubules	microtubule	NNS
cord-280549-bsnz24jx	779	47	,	,	,
cord-280549-bsnz24jx	779	48	membranes	membrane	NNS
cord-280549-bsnz24jx	779	49	and	and	CC
cord-280549-bsnz24jx	779	50	cytokinesis	cytokinesis	NN
cord-280549-bsnz24jx	779	51	Dephosphorylation	dephosphorylation	NN
cord-280549-bsnz24jx	779	52	and	and	CC
cord-280549-bsnz24jx	779	53	activation	activation	NN
cord-280549-bsnz24jx	779	54	of	of	IN
cord-280549-bsnz24jx	779	55	a	a	DT
cord-280549-bsnz24jx	779	56	p34cdc2	p34cdc2	NNP
cord-280549-bsnz24jx	779	57	/	/	SYM
cord-280549-bsnz24jx	779	58	cyclin	cyclin	NN
cord-280549-bsnz24jx	779	59	B	b	NN
cord-280549-bsnz24jx	779	60	complex	complex	NN
cord-280549-bsnz24jx	779	61	in	in	IN
cord-280549-bsnz24jx	779	62	vitro	vitro	FW
cord-280549-bsnz24jx	779	63	by	by	IN
cord-280549-bsnz24jx	779	64	human	human	JJ
cord-280549-bsnz24jx	779	65	CDC25	CDC25	NNP
cord-280549-bsnz24jx	779	66	protein	protein	NN
cord-280549-bsnz24jx	779	67	Simian	simian	JJ
cord-280549-bsnz24jx	779	68	virus	virus	NN
cord-280549-bsnz24jx	780	1	40	40	CD
cord-280549-bsnz24jx	780	2	large	large	JJ
cord-280549-bsnz24jx	780	3	T	t	NN
cord-280549-bsnz24jx	780	4	antigen	antigen	NN
cord-280549-bsnz24jx	780	5	alters	alter	VBZ
cord-280549-bsnz24jx	780	6	the	the	DT
cord-280549-bsnz24jx	780	7	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	780	8	state	state	NN
cord-280549-bsnz24jx	780	9	of	of	IN
cord-280549-bsnz24jx	780	10	the	the	DT
cord-280549-bsnz24jx	780	11	RB	rb	NN
cord-280549-bsnz24jx	780	12	-	-	HYPH
cord-280549-bsnz24jx	780	13	related	relate	VBN
cord-280549-bsnz24jx	780	14	proteins	protein	NNS
cord-280549-bsnz24jx	780	15	p130	p130	NNS
cord-280549-bsnz24jx	781	1	and	and	CC
cord-280549-bsnz24jx	781	2	p107	p107	NNP
cord-280549-bsnz24jx	782	1	The	the	DT
cord-280549-bsnz24jx	782	2	cyclosome	cyclosome	NN
cord-280549-bsnz24jx	782	3	,	,	,
cord-280549-bsnz24jx	782	4	a	a	DT
cord-280549-bsnz24jx	782	5	large	large	JJ
cord-280549-bsnz24jx	782	6	complex	complex	JJ
cord-280549-bsnz24jx	782	7	containing	contain	VBG
cord-280549-bsnz24jx	782	8	cyclin	cyclin	NN
cord-280549-bsnz24jx	782	9	-	-	HYPH
cord-280549-bsnz24jx	782	10	selective	selective	JJ
cord-280549-bsnz24jx	782	11	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	782	12	ligase	ligase	NN
cord-280549-bsnz24jx	782	13	activity	activity	NN
cord-280549-bsnz24jx	782	14	,	,	,
cord-280549-bsnz24jx	782	15	targets	target	VBZ
cord-280549-bsnz24jx	782	16	cyclins	cyclin	NNS
cord-280549-bsnz24jx	782	17	for	for	IN
cord-280549-bsnz24jx	782	18	destruction	destruction	NN
cord-280549-bsnz24jx	782	19	at	at	IN
cord-280549-bsnz24jx	782	20	the	the	DT
cord-280549-bsnz24jx	782	21	end	end	NN
cord-280549-bsnz24jx	782	22	of	of	IN
cord-280549-bsnz24jx	782	23	mitosis	mitosis	NN
cord-280549-bsnz24jx	783	1	The	the	DT
cord-280549-bsnz24jx	783	2	molecular	molecular	JJ
cord-280549-bsnz24jx	783	3	chaperone	chaperone	NN
cord-280549-bsnz24jx	783	4	activity	activity	NN
cord-280549-bsnz24jx	783	5	of	of	IN
cord-280549-bsnz24jx	783	6	simian	simian	JJ
cord-280549-bsnz24jx	783	7	virus	virus	NN
cord-280549-bsnz24jx	783	8	40	40	CD
cord-280549-bsnz24jx	783	9	large	large	JJ
cord-280549-bsnz24jx	783	10	T	t	NN
cord-280549-bsnz24jx	783	11	antigen	antigen	NN
cord-280549-bsnz24jx	783	12	is	be	VBZ
cord-280549-bsnz24jx	783	13	required	require	VBN
cord-280549-bsnz24jx	783	14	to	to	TO
cord-280549-bsnz24jx	783	15	disrupt	disrupt	VB
cord-280549-bsnz24jx	783	16	Rb	Rb	NNP
cord-280549-bsnz24jx	783	17	-	-	HYPH
cord-280549-bsnz24jx	783	18	E2F	e2f	NN
cord-280549-bsnz24jx	783	19	family	family	NN
cord-280549-bsnz24jx	783	20	complexes	complex	NNS
cord-280549-bsnz24jx	783	21	by	by	IN
cord-280549-bsnz24jx	783	22	an	an	DT
cord-280549-bsnz24jx	783	23	ATP	ATP	NNP
cord-280549-bsnz24jx	783	24	-	-	HYPH
cord-280549-bsnz24jx	783	25	dependent	dependent	JJ
cord-280549-bsnz24jx	783	26	mechanism	mechanism	NN
cord-280549-bsnz24jx	783	27	Molecular	molecular	JJ
cord-280549-bsnz24jx	783	28	characterization	characterization	NN
cord-280549-bsnz24jx	783	29	of	of	IN
cord-280549-bsnz24jx	783	30	infectious	infectious	JJ
cord-280549-bsnz24jx	783	31	clones	clone	NNS
cord-280549-bsnz24jx	783	32	of	of	IN
cord-280549-bsnz24jx	783	33	the	the	DT
cord-280549-bsnz24jx	783	34	minute	minute	NN
cord-280549-bsnz24jx	783	35	virus	virus	NN
cord-280549-bsnz24jx	783	36	of	of	IN
cord-280549-bsnz24jx	783	37	canines	canine	NNS
cord-280549-bsnz24jx	783	38	reveals	reveal	VBZ
cord-280549-bsnz24jx	783	39	unique	unique	JJ
cord-280549-bsnz24jx	783	40	features	feature	NNS
cord-280549-bsnz24jx	783	41	of	of	IN
cord-280549-bsnz24jx	783	42	bocaviruses	bocaviruse	NNS
cord-280549-bsnz24jx	784	1	Survivin	Survivin	NNP
cord-280549-bsnz24jx	784	2	initiates	initiate	VBZ
cord-280549-bsnz24jx	784	3	cell	cell	NN
cord-280549-bsnz24jx	784	4	cycle	cycle	NN
cord-280549-bsnz24jx	784	5	entry	entry	NN
cord-280549-bsnz24jx	784	6	by	by	IN
cord-280549-bsnz24jx	784	7	the	the	DT
cord-280549-bsnz24jx	784	8	competitive	competitive	JJ
cord-280549-bsnz24jx	784	9	interaction	interaction	NN
cord-280549-bsnz24jx	784	10	with	with	IN
cord-280549-bsnz24jx	784	11	Cdk4	Cdk4	NNP
cord-280549-bsnz24jx	784	12	/	/	SYM
cord-280549-bsnz24jx	784	13	p16(INK4a	p16(ink4a	NN
cord-280549-bsnz24jx	784	14	)	)	-RRB-
cord-280549-bsnz24jx	784	15	and	and	CC
cord-280549-bsnz24jx	785	1	Cdk2	cdk2	JJ
cord-280549-bsnz24jx	785	2	/	/	SYM
cord-280549-bsnz24jx	785	3	cyclin	cyclin	NN
cord-280549-bsnz24jx	785	4	E	e	NN
cord-280549-bsnz24jx	786	1	complex	complex	JJ
cord-280549-bsnz24jx	786	2	activation	activation	NN
cord-280549-bsnz24jx	786	3	HTLV-1	HTLV-1	NNP
cord-280549-bsnz24jx	786	4	Tax	Tax	NNP
cord-280549-bsnz24jx	786	5	protein	protein	NN
cord-280549-bsnz24jx	786	6	interacts	interact	VBZ
cord-280549-bsnz24jx	786	7	with	with	IN
cord-280549-bsnz24jx	786	8	cyclin	cyclin	NN
cord-280549-bsnz24jx	786	9	-	-	HYPH
cord-280549-bsnz24jx	786	10	dependent	dependent	JJ
cord-280549-bsnz24jx	786	11	kinase	kinase	NN
cord-280549-bsnz24jx	786	12	inhibitor	inhibitor	NN
cord-280549-bsnz24jx	786	13	p16INK4A	p16INK4A	NNP
cord-280549-bsnz24jx	786	14	and	and	CC
cord-280549-bsnz24jx	786	15	counteracts	counteract	VBZ
cord-280549-bsnz24jx	786	16	its	-PRON-	PRP$
cord-280549-bsnz24jx	786	17	inhibitory	inhibitory	JJ
cord-280549-bsnz24jx	786	18	activity	activity	NN
cord-280549-bsnz24jx	786	19	towards	towards	IN
cord-280549-bsnz24jx	786	20	CDK4	CDK4	NNP
cord-280549-bsnz24jx	786	21	Downregulation	Downregulation	NNP
cord-280549-bsnz24jx	786	22	of	of	IN
cord-280549-bsnz24jx	786	23	the	the	DT
cord-280549-bsnz24jx	786	24	INK4	INK4	NNP
cord-280549-bsnz24jx	786	25	family	family	NN
cord-280549-bsnz24jx	786	26	of	of	IN
cord-280549-bsnz24jx	786	27	cyclin	cyclin	NN
cord-280549-bsnz24jx	786	28	-	-	HYPH
cord-280549-bsnz24jx	786	29	dependent	dependent	JJ
cord-280549-bsnz24jx	786	30	kinase	kinase	NN
cord-280549-bsnz24jx	786	31	inhibitors	inhibitor	NNS
cord-280549-bsnz24jx	786	32	by	by	IN
cord-280549-bsnz24jx	786	33	tax	tax	NN
cord-280549-bsnz24jx	786	34	protein	protein	NN
cord-280549-bsnz24jx	786	35	of	of	IN
cord-280549-bsnz24jx	786	36	HTLV-1	HTLV-1	NNP
cord-280549-bsnz24jx	786	37	through	through	IN
cord-280549-bsnz24jx	787	1	two	two	CD
cord-280549-bsnz24jx	787	2	distinct	distinct	JJ
cord-280549-bsnz24jx	787	3	mechanisms	mechanism	NNS
cord-280549-bsnz24jx	787	4	Mammalian	mammalian	JJ
cord-280549-bsnz24jx	787	5	BTBD12	BTBD12	NNP
cord-280549-bsnz24jx	787	6	/	/	SYM
cord-280549-bsnz24jx	787	7	SLX4	SLX4	NNP
cord-280549-bsnz24jx	787	8	assembles	assemble	VBZ
cord-280549-bsnz24jx	787	9	a	a	DT
cord-280549-bsnz24jx	787	10	Holliday	Holliday	NNP
cord-280549-bsnz24jx	787	11	junction	junction	NN
cord-280549-bsnz24jx	787	12	resolvase	resolvase	NN
cord-280549-bsnz24jx	787	13	and	and	CC
cord-280549-bsnz24jx	787	14	is	be	VBZ
cord-280549-bsnz24jx	787	15	required	require	VBN
cord-280549-bsnz24jx	787	16	for	for	IN
cord-280549-bsnz24jx	787	17	DNA	dna	NN
cord-280549-bsnz24jx	787	18	repair	repair	NN
cord-280549-bsnz24jx	787	19	Herpes	Herpes	NNP
cord-280549-bsnz24jx	787	20	viral	viral	JJ
cord-280549-bsnz24jx	787	21	cyclin	cyclin	NN
cord-280549-bsnz24jx	787	22	/	/	SYM
cord-280549-bsnz24jx	787	23	Cdk6	Cdk6	NNP
cord-280549-bsnz24jx	787	24	complexes	complex	NNS
cord-280549-bsnz24jx	787	25	evade	evade	VBP
cord-280549-bsnz24jx	788	1	inhibition	inhibition	NN
cord-280549-bsnz24jx	788	2	by	by	IN
cord-280549-bsnz24jx	788	3	CDK	CDK	NNP
cord-280549-bsnz24jx	788	4	inhibitor	inhibitor	NN
cord-280549-bsnz24jx	788	5	proteins	protein	NNS
cord-280549-bsnz24jx	788	6	EBNA-5	EBNA-5	NNP
cord-280549-bsnz24jx	788	7	,	,	,
cord-280549-bsnz24jx	788	8	an	an	DT
cord-280549-bsnz24jx	788	9	Epstein	Epstein	NNP
cord-280549-bsnz24jx	788	10	-	-	HYPH
cord-280549-bsnz24jx	788	11	Barr	Barr	NNP
cord-280549-bsnz24jx	788	12	virus	virus	NN
cord-280549-bsnz24jx	788	13	-	-	HYPH
cord-280549-bsnz24jx	788	14	encoded	encode	VBN
cord-280549-bsnz24jx	788	15	nuclear	nuclear	JJ
cord-280549-bsnz24jx	788	16	antigen	antigen	NN
cord-280549-bsnz24jx	788	17	,	,	,
cord-280549-bsnz24jx	788	18	binds	bind	VBZ
cord-280549-bsnz24jx	788	19	to	to	IN
cord-280549-bsnz24jx	788	20	the	the	DT
cord-280549-bsnz24jx	788	21	retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	788	22	and	and	CC
cord-280549-bsnz24jx	788	23	p53	p53	NN
cord-280549-bsnz24jx	788	24	proteins	protein	NNS
cord-280549-bsnz24jx	789	1	HIV-1	HIV-1	NNP
cord-280549-bsnz24jx	789	2	Vpr	Vpr	NNP
cord-280549-bsnz24jx	789	3	induces	induce	VBZ
cord-280549-bsnz24jx	789	4	DNA	dna	NN
cord-280549-bsnz24jx	789	5	double	double	JJ
cord-280549-bsnz24jx	789	6	-	-	HYPH
cord-280549-bsnz24jx	789	7	strand	strand	NN
cord-280549-bsnz24jx	789	8	breaks	break	NNS
cord-280549-bsnz24jx	789	9	Identification	identification	NN
cord-280549-bsnz24jx	789	10	of	of	IN
cord-280549-bsnz24jx	789	11	the	the	DT
cord-280549-bsnz24jx	789	12	p53	p53	NN
cord-280549-bsnz24jx	789	13	protein	protein	NN
cord-280549-bsnz24jx	789	14	domain	domain	NN
cord-280549-bsnz24jx	789	15	involved	involve	VBN
cord-280549-bsnz24jx	789	16	in	in	IN
cord-280549-bsnz24jx	789	17	formation	formation	NN
cord-280549-bsnz24jx	789	18	of	of	IN
cord-280549-bsnz24jx	789	19	the	the	DT
cord-280549-bsnz24jx	789	20	simian	simian	JJ
cord-280549-bsnz24jx	789	21	virus-40	virus-40	NN
cord-280549-bsnz24jx	789	22	large	large	JJ
cord-280549-bsnz24jx	789	23	T	t	NN
cord-280549-bsnz24jx	789	24	-	-	HYPH
cord-280549-bsnz24jx	789	25	antigen	antigen	NN
cord-280549-bsnz24jx	789	26	p53	p53	NN
cord-280549-bsnz24jx	789	27	protein	protein	NN
cord-280549-bsnz24jx	789	28	complex	complex	JJ
cord-280549-bsnz24jx	789	29	Zika	Zika	NNP
cord-280549-bsnz24jx	789	30	virus	virus	NN
cord-280549-bsnz24jx	789	31	infects	infect	VBZ
cord-280549-bsnz24jx	789	32	human	human	JJ
cord-280549-bsnz24jx	789	33	cortical	cortical	JJ
cord-280549-bsnz24jx	789	34	neural	neural	JJ
cord-280549-bsnz24jx	789	35	progenitors	progenitor	NNS
cord-280549-bsnz24jx	789	36	and	and	CC
cord-280549-bsnz24jx	789	37	attenuates	attenuate	VBZ
cord-280549-bsnz24jx	789	38	their	-PRON-	PRP$
cord-280549-bsnz24jx	789	39	growth	growth	NN
cord-280549-bsnz24jx	790	1	APC2	APC2	NNP
cord-280549-bsnz24jx	790	2	Cullin	Cullin	NNP
cord-280549-bsnz24jx	790	3	protein	protein	NN
cord-280549-bsnz24jx	790	4	and	and	CC
cord-280549-bsnz24jx	790	5	APC11	APC11	NNP
cord-280549-bsnz24jx	790	6	RING	ring	NN
cord-280549-bsnz24jx	790	7	protein	protein	NN
cord-280549-bsnz24jx	790	8	comprise	comprise	VBP
cord-280549-bsnz24jx	790	9	the	the	DT
cord-280549-bsnz24jx	790	10	minimal	minimal	JJ
cord-280549-bsnz24jx	790	11	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	790	12	ligase	ligase	NN
cord-280549-bsnz24jx	790	13	module	module	NN
cord-280549-bsnz24jx	790	14	of	of	IN
cord-280549-bsnz24jx	790	15	the	the	DT
cord-280549-bsnz24jx	790	16	anaphase	anaphase	NN
cord-280549-bsnz24jx	790	17	-	-	HYPH
cord-280549-bsnz24jx	790	18	promoting	promote	VBG
cord-280549-bsnz24jx	790	19	complex	complex	JJ
cord-280549-bsnz24jx	790	20	Identification	identification	NN
cord-280549-bsnz24jx	790	21	of	of	IN
cord-280549-bsnz24jx	790	22	human	human	JJ
cord-280549-bsnz24jx	790	23	cyclin	cyclin	NN
cord-280549-bsnz24jx	790	24	-	-	HYPH
cord-280549-bsnz24jx	790	25	dependent	dependent	JJ
cord-280549-bsnz24jx	790	26	kinase	kinase	NN
cord-280549-bsnz24jx	790	27	8	8	CD
cord-280549-bsnz24jx	790	28	,	,	,
cord-280549-bsnz24jx	790	29	a	a	DT
cord-280549-bsnz24jx	790	30	putative	putative	JJ
cord-280549-bsnz24jx	790	31	protein	protein	NN
cord-280549-bsnz24jx	790	32	kinase	kinase	NN
cord-280549-bsnz24jx	790	33	partner	partner	NN
cord-280549-bsnz24jx	790	34	for	for	IN
cord-280549-bsnz24jx	790	35	cyclin	cyclin	NN
cord-280549-bsnz24jx	790	36	C	C	NNP
cord-280549-bsnz24jx	791	1	The	the	DT
cord-280549-bsnz24jx	791	2	viral	viral	JJ
cord-280549-bsnz24jx	791	3	protein	protein	NN
cord-280549-bsnz24jx	791	4	Apoptin	Apoptin	NNP
cord-280549-bsnz24jx	791	5	associates	associate	NNS
cord-280549-bsnz24jx	791	6	with	with	IN
cord-280549-bsnz24jx	791	7	the	the	DT
cord-280549-bsnz24jx	791	8	anaphase	anaphase	NN
cord-280549-bsnz24jx	791	9	-	-	HYPH
cord-280549-bsnz24jx	791	10	promoting	promote	VBG
cord-280549-bsnz24jx	791	11	complex	complex	NN
cord-280549-bsnz24jx	791	12	to	to	TO
cord-280549-bsnz24jx	791	13	induce	induce	VB
cord-280549-bsnz24jx	791	14	G2	G2	NNP
cord-280549-bsnz24jx	791	15	/	/	SYM
cord-280549-bsnz24jx	791	16	M	M	NNP
cord-280549-bsnz24jx	791	17	arrest	arrest	NN
cord-280549-bsnz24jx	791	18	and	and	CC
cord-280549-bsnz24jx	791	19	apoptosis	apoptosis	NN
cord-280549-bsnz24jx	791	20	in	in	IN
cord-280549-bsnz24jx	791	21	the	the	DT
cord-280549-bsnz24jx	791	22	absence	absence	NN
cord-280549-bsnz24jx	791	23	of	of	IN
cord-280549-bsnz24jx	791	24	p53	p53	NN
cord-280549-bsnz24jx	791	25	Dissociation	Dissociation	NNP
cord-280549-bsnz24jx	791	26	of	of	IN
cord-280549-bsnz24jx	791	27	Rb	Rb	NNP
cord-280549-bsnz24jx	791	28	-	-	HYPH
cord-280549-bsnz24jx	791	29	binding	bind	VBG
cord-280549-bsnz24jx	791	30	and	and	CC
cord-280549-bsnz24jx	791	31	anchorage	anchorage	NN
cord-280549-bsnz24jx	791	32	-	-	HYPH
cord-280549-bsnz24jx	791	33	independent	independent	JJ
cord-280549-bsnz24jx	791	34	growth	growth	NN
cord-280549-bsnz24jx	791	35	from	from	IN
cord-280549-bsnz24jx	791	36	immortalization	immortalization	NN
cord-280549-bsnz24jx	791	37	and	and	CC
cord-280549-bsnz24jx	791	38	tumorigenicity	tumorigenicity	NN
cord-280549-bsnz24jx	791	39	using	use	VBG
cord-280549-bsnz24jx	791	40	SV40	SV40	NNP
cord-280549-bsnz24jx	791	41	mutants	mutant	NNS
cord-280549-bsnz24jx	791	42	producing	produce	VBG
cord-280549-bsnz24jx	791	43	N	n	CD
cord-280549-bsnz24jx	791	44	-	-	HYPH
cord-280549-bsnz24jx	791	45	terminally	terminally	RB
cord-280549-bsnz24jx	791	46	truncated	truncate	VBD
cord-280549-bsnz24jx	791	47	large	large	JJ
cord-280549-bsnz24jx	791	48	T	t	NN
cord-280549-bsnz24jx	791	49	antigens	antigen	NNS
cord-280549-bsnz24jx	792	1	A	a	DT
cord-280549-bsnz24jx	792	2	79	79	CD
cord-280549-bsnz24jx	792	3	amino	amino	NN
cord-280549-bsnz24jx	792	4	acid	acid	NN
cord-280549-bsnz24jx	792	5	oncogene	oncogene	NN
cord-280549-bsnz24jx	792	6	is	be	VBZ
cord-280549-bsnz24jx	792	7	responsible	responsible	JJ
cord-280549-bsnz24jx	792	8	for	for	IN
cord-280549-bsnz24jx	792	9	human	human	JJ
cord-280549-bsnz24jx	792	10	cytomegalovirus	cytomegalovirus	NN
cord-280549-bsnz24jx	792	11	mtrII	mtrii	NN
cord-280549-bsnz24jx	792	12	induced	induce	VBN
cord-280549-bsnz24jx	792	13	malignant	malignant	JJ
cord-280549-bsnz24jx	792	14	transformation	transformation	NN
cord-280549-bsnz24jx	793	1	Securin	Securin	NNP
cord-280549-bsnz24jx	793	2	and	and	CC
cord-280549-bsnz24jx	793	3	B	b	NN
cord-280549-bsnz24jx	793	4	-	-	HYPH
cord-280549-bsnz24jx	793	5	cyclin	cyclin	NN
cord-280549-bsnz24jx	793	6	/	/	SYM
cord-280549-bsnz24jx	793	7	CDK	CDK	NNP
cord-280549-bsnz24jx	793	8	are	be	VBP
cord-280549-bsnz24jx	793	9	the	the	DT
cord-280549-bsnz24jx	793	10	only	only	JJ
cord-280549-bsnz24jx	793	11	essential	essential	JJ
cord-280549-bsnz24jx	793	12	targets	target	NNS
cord-280549-bsnz24jx	793	13	of	of	IN
cord-280549-bsnz24jx	793	14	the	the	DT
cord-280549-bsnz24jx	793	15	APC	APC	NNP
cord-280549-bsnz24jx	793	16	Human	Human	NNP
cord-280549-bsnz24jx	793	17	cytomegalovirus	cytomegalovirus	NN
cord-280549-bsnz24jx	793	18	immediate	immediate	JJ
cord-280549-bsnz24jx	793	19	-	-	HYPH
cord-280549-bsnz24jx	793	20	early	early	JJ
cord-280549-bsnz24jx	793	21	protein	protein	NN
cord-280549-bsnz24jx	793	22	IE2	ie2	NN
cord-280549-bsnz24jx	793	23	tethers	tether	NNS
cord-280549-bsnz24jx	793	24	a	a	DT
cord-280549-bsnz24jx	793	25	transcriptional	transcriptional	JJ
cord-280549-bsnz24jx	793	26	repression	repression	NN
cord-280549-bsnz24jx	793	27	domain	domain	NN
cord-280549-bsnz24jx	793	28	to	to	IN
cord-280549-bsnz24jx	793	29	p53	p53	NN
cord-280549-bsnz24jx	793	30	Identification	identification	NN
cord-280549-bsnz24jx	793	31	of	of	IN
cord-280549-bsnz24jx	793	32	target	target	NN
cord-280549-bsnz24jx	793	33	genes	gene	NNS
cord-280549-bsnz24jx	793	34	for	for	IN
cord-280549-bsnz24jx	793	35	the	the	DT
cord-280549-bsnz24jx	793	36	CDK	CDK	NNP
cord-280549-bsnz24jx	793	37	subunits	subunit	NNS
cord-280549-bsnz24jx	793	38	of	of	IN
cord-280549-bsnz24jx	793	39	the	the	DT
cord-280549-bsnz24jx	793	40	Mediator	Mediator	NNP
cord-280549-bsnz24jx	793	41	complex	complex	NN
cord-280549-bsnz24jx	793	42	Targeted	target	VBN
cord-280549-bsnz24jx	793	43	disruption	disruption	NN
cord-280549-bsnz24jx	793	44	of	of	IN
cord-280549-bsnz24jx	793	45	CDK4	CDK4	NNP
cord-280549-bsnz24jx	793	46	delays	delay	NNS
cord-280549-bsnz24jx	793	47	cell	cell	NN
cord-280549-bsnz24jx	793	48	cycle	cycle	NN
cord-280549-bsnz24jx	793	49	entry	entry	NN
cord-280549-bsnz24jx	793	50	with	with	IN
cord-280549-bsnz24jx	793	51	enhanced	enhanced	JJ
cord-280549-bsnz24jx	793	52	p27(Kip1	p27(kip1	NN
cord-280549-bsnz24jx	793	53	)	)	-RRB-
cord-280549-bsnz24jx	793	54	activity	activity	NN
cord-280549-bsnz24jx	793	55	Human	human	JJ
cord-280549-bsnz24jx	793	56	mediator	mediator	NN
cord-280549-bsnz24jx	793	57	kinase	kinase	VBZ
cord-280549-bsnz24jx	793	58	subunit	subunit	NN
cord-280549-bsnz24jx	794	1	CDK11	CDK11	NNP
cord-280549-bsnz24jx	794	2	plays	play	VBZ
cord-280549-bsnz24jx	794	3	a	a	DT
cord-280549-bsnz24jx	794	4	negative	negative	JJ
cord-280549-bsnz24jx	794	5	role	role	NN
cord-280549-bsnz24jx	794	6	in	in	IN
cord-280549-bsnz24jx	794	7	viral	viral	JJ
cord-280549-bsnz24jx	794	8	activator	activator	NN
cord-280549-bsnz24jx	794	9	VP16-dependent	vp16-dependent	CD
cord-280549-bsnz24jx	794	10	transcriptional	transcriptional	NN
cord-280549-bsnz24jx	794	11	regulation	regulation	NN
cord-280549-bsnz24jx	795	1	The	the	DT
cord-280549-bsnz24jx	795	2	VP16	VP16	NNP
cord-280549-bsnz24jx	795	3	activation	activation	NN
cord-280549-bsnz24jx	795	4	domain	domain	NN
cord-280549-bsnz24jx	795	5	establishes	establish	VBZ
cord-280549-bsnz24jx	795	6	an	an	DT
cord-280549-bsnz24jx	795	7	active	active	JJ
cord-280549-bsnz24jx	795	8	mediator	mediator	NN
cord-280549-bsnz24jx	795	9	lacking	lack	VBG
cord-280549-bsnz24jx	795	10	CDK8	CDK8	NNP
cord-280549-bsnz24jx	795	11	in	in	IN
cord-280549-bsnz24jx	795	12	vivo	vivo	NN
cord-280549-bsnz24jx	796	1	The	the	DT
cord-280549-bsnz24jx	796	2	murine	murine	JJ
cord-280549-bsnz24jx	796	3	gammaherpesvirus	gammaherpesvirus	NNP
cord-280549-bsnz24jx	796	4	68	68	CD
cord-280549-bsnz24jx	796	5	v	v	NN
cord-280549-bsnz24jx	796	6	-	-	HYPH
cord-280549-bsnz24jx	796	7	cyclin	cyclin	NN
cord-280549-bsnz24jx	796	8	gene	gene	NN
cord-280549-bsnz24jx	796	9	is	be	VBZ
cord-280549-bsnz24jx	796	10	an	an	DT
cord-280549-bsnz24jx	796	11	oncogene	oncogene	NN
cord-280549-bsnz24jx	796	12	that	that	WDT
cord-280549-bsnz24jx	796	13	promotes	promote	VBZ
cord-280549-bsnz24jx	796	14	cell	cell	NN
cord-280549-bsnz24jx	796	15	cycle	cycle	NN
cord-280549-bsnz24jx	796	16	progression	progression	NN
cord-280549-bsnz24jx	796	17	in	in	IN
cord-280549-bsnz24jx	796	18	primary	primary	JJ
cord-280549-bsnz24jx	796	19	lymphocytes	lymphocyte	NNS
cord-280549-bsnz24jx	796	20	Complete	complete	JJ
cord-280549-bsnz24jx	796	21	sequence	sequence	NN
cord-280549-bsnz24jx	796	22	and	and	CC
cord-280549-bsnz24jx	796	23	genomic	genomic	JJ
cord-280549-bsnz24jx	796	24	analysis	analysis	NN
cord-280549-bsnz24jx	796	25	of	of	IN
cord-280549-bsnz24jx	796	26	murine	murine	JJ
cord-280549-bsnz24jx	796	27	gammaherpesvirus	gammaherpesvirus	NNP
cord-280549-bsnz24jx	796	28	68	68	CD
cord-280549-bsnz24jx	796	29	Phosphorylation	Phosphorylation	NNP
cord-280549-bsnz24jx	796	30	-	-	HYPH
cord-280549-bsnz24jx	796	31	dependent	dependent	JJ
cord-280549-bsnz24jx	796	32	degradation	degradation	NN
cord-280549-bsnz24jx	796	33	of	of	IN
cord-280549-bsnz24jx	796	34	the	the	DT
cord-280549-bsnz24jx	796	35	cyclin	cyclin	NN
cord-280549-bsnz24jx	796	36	-	-	HYPH
cord-280549-bsnz24jx	796	37	dependent	dependent	JJ
cord-280549-bsnz24jx	796	38	kinase	kinase	NN
cord-280549-bsnz24jx	796	39	inhibitor	inhibitor	NN
cord-280549-bsnz24jx	796	40	p27	p27	NN
cord-280549-bsnz24jx	797	1	The	the	DT
cord-280549-bsnz24jx	797	2	nuclear	nuclear	JJ
cord-280549-bsnz24jx	797	3	ubiquitin	ubiquitin	NN
cord-280549-bsnz24jx	797	4	-	-	HYPH
cord-280549-bsnz24jx	797	5	proteasome	proteasome	VBN
cord-280549-bsnz24jx	797	6	system	system	NN
cord-280549-bsnz24jx	797	7	Human	human	JJ
cord-280549-bsnz24jx	797	8	parvovirus	parvovirus	NN
cord-280549-bsnz24jx	797	9	B19	B19	NNP
cord-280549-bsnz24jx	797	10	causes	cause	VBZ
cord-280549-bsnz24jx	797	11	cell	cell	NN
cord-280549-bsnz24jx	797	12	cycle	cycle	NN
cord-280549-bsnz24jx	797	13	arrest	arrest	NN
cord-280549-bsnz24jx	797	14	of	of	IN
cord-280549-bsnz24jx	797	15	human	human	JJ
cord-280549-bsnz24jx	797	16	erythroid	erythroid	NN
cord-280549-bsnz24jx	797	17	progenitors	progenitor	NNS
cord-280549-bsnz24jx	797	18	via	via	IN
cord-280549-bsnz24jx	797	19	deregulation	deregulation	NN
cord-280549-bsnz24jx	797	20	of	of	IN
cord-280549-bsnz24jx	797	21	the	the	DT
cord-280549-bsnz24jx	797	22	E2F	E2F	NNP
cord-280549-bsnz24jx	797	23	family	family	NN
cord-280549-bsnz24jx	797	24	of	of	IN
cord-280549-bsnz24jx	797	25	transcription	transcription	NN
cord-280549-bsnz24jx	797	26	factors	factor	NNS
cord-280549-bsnz24jx	797	27	Complex	complex	JJ
cord-280549-bsnz24jx	797	28	formation	formation	NN
cord-280549-bsnz24jx	797	29	between	between	IN
cord-280549-bsnz24jx	797	30	hepatitis	hepatitis	NN
cord-280549-bsnz24jx	797	31	C	C	NNP
cord-280549-bsnz24jx	797	32	virus	virus	NN
cord-280549-bsnz24jx	797	33	core	core	NN
cord-280549-bsnz24jx	797	34	protein	protein	NN
cord-280549-bsnz24jx	797	35	and	and	CC
cord-280549-bsnz24jx	797	36	p21Waf1	p21waf1	CD
cord-280549-bsnz24jx	797	37	/	/	SYM
cord-280549-bsnz24jx	797	38	Cip1	Cip1	NNP
cord-280549-bsnz24jx	797	39	/	/	SYM
cord-280549-bsnz24jx	797	40	Sdi1	Sdi1	NNP
cord-280549-bsnz24jx	797	41	Activated	activate	VBN
cord-280549-bsnz24jx	797	42	Notch	Notch	NNP
cord-280549-bsnz24jx	797	43	signaling	signaling	NN
cord-280549-bsnz24jx	797	44	is	be	VBZ
cord-280549-bsnz24jx	797	45	required	require	VBN
cord-280549-bsnz24jx	797	46	for	for	IN
cord-280549-bsnz24jx	797	47	hepatitis	hepatitis	NNP
cord-280549-bsnz24jx	797	48	B	B	NNP
cord-280549-bsnz24jx	797	49	virus	virus	NN
cord-280549-bsnz24jx	797	50	X	x	NN
cord-280549-bsnz24jx	797	51	protein	protein	NN
cord-280549-bsnz24jx	797	52	to	to	TO
cord-280549-bsnz24jx	797	53	promote	promote	VB
cord-280549-bsnz24jx	797	54	proliferation	proliferation	NN
cord-280549-bsnz24jx	797	55	and	and	CC
cord-280549-bsnz24jx	797	56	survival	survival	NN
cord-280549-bsnz24jx	797	57	of	of	IN
cord-280549-bsnz24jx	797	58	human	human	JJ
cord-280549-bsnz24jx	797	59	hepatic	hepatic	JJ
cord-280549-bsnz24jx	797	60	cells	cell	NNS
cord-280549-bsnz24jx	797	61	Cytomegalovirus	Cytomegalovirus	NNP
cord-280549-bsnz24jx	797	62	inhibits	inhibit	VBZ
cord-280549-bsnz24jx	798	1	p53	p53	NN
cord-280549-bsnz24jx	798	2	nuclear	nuclear	JJ
cord-280549-bsnz24jx	798	3	localization	localization	NN
cord-280549-bsnz24jx	798	4	signal	signal	NN
cord-280549-bsnz24jx	798	5	function	function	NN
cord-280549-bsnz24jx	798	6	Stabilization	stabilization	NN
cord-280549-bsnz24jx	798	7	of	of	IN
cord-280549-bsnz24jx	798	8	p53	p53	NN
cord-280549-bsnz24jx	798	9	in	in	IN
cord-280549-bsnz24jx	799	1	influenza	influenza	NN
cord-280549-bsnz24jx	799	2	A	a	DT
cord-280549-bsnz24jx	799	3	virus	virus	NN
cord-280549-bsnz24jx	799	4	-	-	HYPH
cord-280549-bsnz24jx	799	5	infected	infect	VBN
cord-280549-bsnz24jx	799	6	cells	cell	NNS
cord-280549-bsnz24jx	799	7	is	be	VBZ
cord-280549-bsnz24jx	799	8	associated	associate	VBN
cord-280549-bsnz24jx	799	9	with	with	IN
cord-280549-bsnz24jx	799	10	compromised	compromised	JJ
cord-280549-bsnz24jx	799	11	MDM2-mediated	mdm2-mediated	JJ
cord-280549-bsnz24jx	799	12	ubiquitination	ubiquitination	NN
cord-280549-bsnz24jx	799	13	of	of	IN
cord-280549-bsnz24jx	799	14	p53	p53	NN
cord-280549-bsnz24jx	800	1	The	the	DT
cord-280549-bsnz24jx	800	2	anaphase	anaphase	NN
cord-280549-bsnz24jx	800	3	-	-	HYPH
cord-280549-bsnz24jx	800	4	promoting	promote	VBG
cord-280549-bsnz24jx	800	5	complex	complex	NN
cord-280549-bsnz24jx	800	6	is	be	VBZ
cord-280549-bsnz24jx	800	7	required	require	VBN
cord-280549-bsnz24jx	800	8	in	in	IN
cord-280549-bsnz24jx	800	9	both	both	DT
cord-280549-bsnz24jx	800	10	dividing	divide	VBG
cord-280549-bsnz24jx	800	11	and	and	CC
cord-280549-bsnz24jx	800	12	quiescent	quiescent	JJ
cord-280549-bsnz24jx	800	13	cells	cell	NNS
cord-280549-bsnz24jx	800	14	during	during	IN
cord-280549-bsnz24jx	800	15	zebrafish	zebrafish	NN
cord-280549-bsnz24jx	800	16	development	development	NN
cord-280549-bsnz24jx	800	17	Degradation	degradation	NN
cord-280549-bsnz24jx	800	18	of	of	IN
cord-280549-bsnz24jx	800	19	the	the	DT
cord-280549-bsnz24jx	800	20	SCF	scf	NN
cord-280549-bsnz24jx	800	21	component	component	NN
cord-280549-bsnz24jx	800	22	Skp2	Skp2	NNP
cord-280549-bsnz24jx	800	23	in	in	IN
cord-280549-bsnz24jx	800	24	cell	cell	NN
cord-280549-bsnz24jx	800	25	-	-	HYPH
cord-280549-bsnz24jx	800	26	cycle	cycle	NN
cord-280549-bsnz24jx	800	27	phase	phase	NN
cord-280549-bsnz24jx	800	28	G1	g1	NN
cord-280549-bsnz24jx	800	29	by	by	IN
cord-280549-bsnz24jx	800	30	the	the	DT
cord-280549-bsnz24jx	800	31	anaphase	anaphase	NN
cord-280549-bsnz24jx	800	32	-	-	HYPH
cord-280549-bsnz24jx	800	33	promoting	promote	VBG
cord-280549-bsnz24jx	800	34	complex	complex	JJ
cord-280549-bsnz24jx	800	35	Tumor	tumor	NN
cord-280549-bsnz24jx	800	36	suppressor	suppressor	NN
cord-280549-bsnz24jx	800	37	genes	gene	NNS
cord-280549-bsnz24jx	801	1	The	the	DT
cord-280549-bsnz24jx	801	2	retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	801	3	protein	protein	NN
cord-280549-bsnz24jx	801	4	and	and	CC
cord-280549-bsnz24jx	801	5	cell	cell	NN
cord-280549-bsnz24jx	801	6	cycle	cycle	NN
cord-280549-bsnz24jx	801	7	control	control	NN
cord-280549-bsnz24jx	802	1	The	the	DT
cord-280549-bsnz24jx	802	2	cat	cat	NN
cord-280549-bsnz24jx	802	3	and	and	CC
cord-280549-bsnz24jx	802	4	mouse	mouse	NN
cord-280549-bsnz24jx	802	5	games	game	NNS
cord-280549-bsnz24jx	802	6	that	that	WDT
cord-280549-bsnz24jx	802	7	genes	gene	NNS
cord-280549-bsnz24jx	802	8	,	,	,
cord-280549-bsnz24jx	802	9	viruses	virus	NNS
cord-280549-bsnz24jx	802	10	,	,	,
cord-280549-bsnz24jx	802	11	and	and	CC
cord-280549-bsnz24jx	802	12	cells	cell	NNS
cord-280549-bsnz24jx	802	13	play	play	VBP
cord-280549-bsnz24jx	802	14	Association	Association	NNP
cord-280549-bsnz24jx	802	15	of	of	IN
cord-280549-bsnz24jx	802	16	human	human	JJ
cord-280549-bsnz24jx	802	17	papillomavirus	papillomavirus	NN
cord-280549-bsnz24jx	802	18	types	type	NNS
cord-280549-bsnz24jx	802	19	16	16	CD
cord-280549-bsnz24jx	802	20	and	and	CC
cord-280549-bsnz24jx	802	21	18	18	CD
cord-280549-bsnz24jx	802	22	E6	e6	NN
cord-280549-bsnz24jx	802	23	proteins	protein	NNS
cord-280549-bsnz24jx	802	24	with	with	IN
cord-280549-bsnz24jx	802	25	p53	p53	NN
cord-280549-bsnz24jx	802	26	DDB	DDB	NNP
cord-280549-bsnz24jx	802	27	complexities	complexity	NNS
cord-280549-bsnz24jx	803	1	The	the	DT
cord-280549-bsnz24jx	803	2	human	human	JJ
cord-280549-bsnz24jx	803	3	papillomavirus	papillomavirus	NN
cord-280549-bsnz24jx	803	4	E7	E7	NNP
cord-280549-bsnz24jx	803	5	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	803	6	and	and	CC
cord-280549-bsnz24jx	803	7	the	the	DT
cord-280549-bsnz24jx	803	8	cellular	cellular	JJ
cord-280549-bsnz24jx	803	9	transcription	transcription	NN
cord-280549-bsnz24jx	803	10	factor	factor	NN
cord-280549-bsnz24jx	803	11	E2F	e2f	NN
cord-280549-bsnz24jx	803	12	bind	bind	VBP
cord-280549-bsnz24jx	803	13	to	to	IN
cord-280549-bsnz24jx	803	14	separate	separate	JJ
cord-280549-bsnz24jx	803	15	sites	site	NNS
cord-280549-bsnz24jx	803	16	on	on	IN
cord-280549-bsnz24jx	803	17	the	the	DT
cord-280549-bsnz24jx	803	18	retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	803	19	tumor	tumor	NN
cord-280549-bsnz24jx	803	20	suppressor	suppressor	NN
cord-280549-bsnz24jx	803	21	protein	protein	NN
cord-280549-bsnz24jx	803	22	Chk1	Chk1	NNP
cord-280549-bsnz24jx	803	23	mediates	mediate	VBZ
cord-280549-bsnz24jx	803	24	S	S	NNP
cord-280549-bsnz24jx	803	25	and	and	CC
cord-280549-bsnz24jx	803	26	G2	G2	NNP
cord-280549-bsnz24jx	803	27	arrests	arrest	NNS
cord-280549-bsnz24jx	803	28	through	through	IN
cord-280549-bsnz24jx	803	29	Cdc25A	Cdc25A	NNP
cord-280549-bsnz24jx	803	30	degradation	degradation	NN
cord-280549-bsnz24jx	803	31	in	in	IN
cord-280549-bsnz24jx	803	32	response	response	NN
cord-280549-bsnz24jx	803	33	to	to	IN
cord-280549-bsnz24jx	803	34	DNA	dna	NN
cord-280549-bsnz24jx	803	35	-	-	HYPH
cord-280549-bsnz24jx	803	36	damaging	damaging	JJ
cord-280549-bsnz24jx	803	37	agents	agent	NNS
cord-280549-bsnz24jx	803	38	Hepatitis	Hepatitis	NNP
cord-280549-bsnz24jx	803	39	B	B	NNP
cord-280549-bsnz24jx	803	40	virus	virus	NN
cord-280549-bsnz24jx	804	1	X	x	NN
cord-280549-bsnz24jx	804	2	protein	protein	NN
cord-280549-bsnz24jx	804	3	blunts	blunt	NNS
cord-280549-bsnz24jx	804	4	senescence	senescence	NN
cord-280549-bsnz24jx	804	5	-	-	HYPH
cord-280549-bsnz24jx	804	6	like	like	JJ
cord-280549-bsnz24jx	804	7	growth	growth	NN
cord-280549-bsnz24jx	804	8	arrest	arrest	NN
cord-280549-bsnz24jx	804	9	of	of	IN
cord-280549-bsnz24jx	804	10	human	human	JJ
cord-280549-bsnz24jx	804	11	hepatocellular	hepatocellular	JJ
cord-280549-bsnz24jx	804	12	carcinoma	carcinoma	NN
cord-280549-bsnz24jx	804	13	by	by	IN
cord-280549-bsnz24jx	804	14	reducing	reduce	VBG
cord-280549-bsnz24jx	804	15	Notch1	Notch1	NNP
cord-280549-bsnz24jx	804	16	cleavage	cleavage	NN
cord-280549-bsnz24jx	804	17	Cell	cell	NN
cord-280549-bsnz24jx	804	18	cycle	cycle	NN
cord-280549-bsnz24jx	804	19	mechanisms	mechanism	NNS
cord-280549-bsnz24jx	804	20	of	of	IN
cord-280549-bsnz24jx	804	21	sister	sister	NN
cord-280549-bsnz24jx	804	22	chromatid	chromatid	NN
cord-280549-bsnz24jx	804	23	separation	separation	NN
cord-280549-bsnz24jx	804	24	;	;	:
cord-280549-bsnz24jx	804	25	Roles	Roles	NNP
cord-280549-bsnz24jx	804	26	of	of	IN
cord-280549-bsnz24jx	804	27	Cut1	Cut1	NNP
cord-280549-bsnz24jx	804	28	/	/	SYM
cord-280549-bsnz24jx	804	29	separin	separin	NNP
cord-280549-bsnz24jx	804	30	and	and	CC
cord-280549-bsnz24jx	804	31	Cut2	Cut2	NNP
cord-280549-bsnz24jx	804	32	/	/	SYM
cord-280549-bsnz24jx	804	33	securin	securin	NNP
cord-280549-bsnz24jx	804	34	Varicella	Varicella	NNP
cord-280549-bsnz24jx	804	35	-	-	HYPH
cord-280549-bsnz24jx	804	36	zoster	zoster	NN
cord-280549-bsnz24jx	804	37	virus	virus	NN
cord-280549-bsnz24jx	805	1	IE62	IE62	NNP
cord-280549-bsnz24jx	805	2	protein	protein	NN
cord-280549-bsnz24jx	805	3	utilizes	utilize	VBZ
cord-280549-bsnz24jx	805	4	the	the	DT
cord-280549-bsnz24jx	805	5	human	human	JJ
cord-280549-bsnz24jx	805	6	mediator	mediator	NN
cord-280549-bsnz24jx	805	7	complex	complex	NN
cord-280549-bsnz24jx	805	8	in	in	IN
cord-280549-bsnz24jx	805	9	promoter	promoter	NN
cord-280549-bsnz24jx	805	10	activation	activation	NN
cord-280549-bsnz24jx	805	11	Differential	differential	NN
cord-280549-bsnz24jx	805	12	regulation	regulation	NN
cord-280549-bsnz24jx	805	13	of	of	IN
cord-280549-bsnz24jx	805	14	the	the	DT
cord-280549-bsnz24jx	805	15	cyclin	cyclin	NN
cord-280549-bsnz24jx	805	16	-	-	HYPH
cord-280549-bsnz24jx	805	17	dependent	dependent	JJ
cord-280549-bsnz24jx	805	18	kinase	kinase	NN
cord-280549-bsnz24jx	805	19	inhibitors	inhibitor	NNS
cord-280549-bsnz24jx	805	20	p21(Cip1	p21(Cip1	NNP
cord-280549-bsnz24jx	805	21	)	)	-RRB-
cord-280549-bsnz24jx	805	22	and	and	CC
cord-280549-bsnz24jx	805	23	p27(Kip1	p27(kip1	NN
cord-280549-bsnz24jx	805	24	)	)	-RRB-
cord-280549-bsnz24jx	805	25	by	by	IN
cord-280549-bsnz24jx	805	26	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	805	27	directed	direct	VBN
cord-280549-bsnz24jx	805	28	by	by	IN
cord-280549-bsnz24jx	805	29	the	the	DT
cord-280549-bsnz24jx	805	30	cyclin	cyclin	NN
cord-280549-bsnz24jx	805	31	encoded	encode	VBN
cord-280549-bsnz24jx	805	32	by	by	IN
cord-280549-bsnz24jx	805	33	Murine	Murine	NNP
cord-280549-bsnz24jx	805	34	Herpesvirus	Herpesvirus	NNP
cord-280549-bsnz24jx	805	35	68	68	CD
cord-280549-bsnz24jx	805	36	A	a	DT
cord-280549-bsnz24jx	805	37	premature	premature	JJ
cord-280549-bsnz24jx	805	38	-	-	HYPH
cord-280549-bsnz24jx	805	39	termination	termination	NN
cord-280549-bsnz24jx	805	40	mutation	mutation	NN
cord-280549-bsnz24jx	805	41	in	in	IN
cord-280549-bsnz24jx	805	42	the	the	DT
cord-280549-bsnz24jx	805	43	Mus	Mus	NNP
cord-280549-bsnz24jx	805	44	musculus	musculus	NN
cord-280549-bsnz24jx	805	45	cyclin	cyclin	NN
cord-280549-bsnz24jx	805	46	-	-	HYPH
cord-280549-bsnz24jx	805	47	dependent	dependent	JJ
cord-280549-bsnz24jx	805	48	kinase	kinase	NN
cord-280549-bsnz24jx	805	49	3	3	CD
cord-280549-bsnz24jx	805	50	gene	gene	NN
cord-280549-bsnz24jx	805	51	Prognostic	prognostic	JJ
cord-280549-bsnz24jx	805	52	significance	significance	NN
cord-280549-bsnz24jx	805	53	of	of	IN
cord-280549-bsnz24jx	805	54	the	the	DT
cord-280549-bsnz24jx	805	55	Epstein	Epstein	NNP
cord-280549-bsnz24jx	805	56	-	-	HYPH
cord-280549-bsnz24jx	805	57	Barr	Barr	NNP
cord-280549-bsnz24jx	805	58	virus	virus	NN
cord-280549-bsnz24jx	805	59	,	,	,
cord-280549-bsnz24jx	805	60	p53	p53	NN
cord-280549-bsnz24jx	805	61	,	,	,
cord-280549-bsnz24jx	805	62	Bcl-2	Bcl-2	NNP
cord-280549-bsnz24jx	805	63	,	,	,
cord-280549-bsnz24jx	805	64	and	and	CC
cord-280549-bsnz24jx	805	65	survivin	survivin	NN
cord-280549-bsnz24jx	805	66	in	in	IN
cord-280549-bsnz24jx	805	67	nasopharyngeal	nasopharyngeal	JJ
cord-280549-bsnz24jx	805	68	cancer	cancer	NN
cord-280549-bsnz24jx	805	69	Enterovirus	Enterovirus	NNP
cord-280549-bsnz24jx	805	70	71	71	CD
cord-280549-bsnz24jx	805	71	mediates	mediate	VBZ
cord-280549-bsnz24jx	805	72	cell	cell	NN
cord-280549-bsnz24jx	805	73	cycle	cycle	NN
cord-280549-bsnz24jx	805	74	arrest	arrest	NN
cord-280549-bsnz24jx	805	75	in	in	IN
cord-280549-bsnz24jx	805	76	S	S	NNP
cord-280549-bsnz24jx	805	77	phase	phase	NN
cord-280549-bsnz24jx	805	78	through	through	IN
cord-280549-bsnz24jx	805	79	non	non	JJ
cord-280549-bsnz24jx	805	80	-	-	JJ
cord-280549-bsnz24jx	805	81	structural	structural	JJ
cord-280549-bsnz24jx	805	82	protein	protein	NN
cord-280549-bsnz24jx	805	83	3D	3D	NNP
cord-280549-bsnz24jx	806	1	The	the	DT
cord-280549-bsnz24jx	806	2	Epstein	Epstein	NNP
cord-280549-bsnz24jx	806	3	-	-	HYPH
cord-280549-bsnz24jx	806	4	Barr	Barr	NNP
cord-280549-bsnz24jx	806	5	virus	virus	NN
cord-280549-bsnz24jx	806	6	immediate	immediate	JJ
cord-280549-bsnz24jx	806	7	-	-	HYPH
cord-280549-bsnz24jx	806	8	early	early	JJ
cord-280549-bsnz24jx	806	9	gene	gene	NN
cord-280549-bsnz24jx	806	10	product	product	NN
cord-280549-bsnz24jx	806	11	,	,	,
cord-280549-bsnz24jx	806	12	BRLF1	BRLF1	NNP
cord-280549-bsnz24jx	806	13	,	,	,
cord-280549-bsnz24jx	806	14	interacts	interact	VBZ
cord-280549-bsnz24jx	806	15	with	with	IN
cord-280549-bsnz24jx	806	16	the	the	DT
cord-280549-bsnz24jx	806	17	retinoblastoma	retinoblastoma	NN
cord-280549-bsnz24jx	806	18	protein	protein	NN
cord-280549-bsnz24jx	806	19	during	during	IN
cord-280549-bsnz24jx	806	20	the	the	DT
cord-280549-bsnz24jx	806	21	viral	viral	JJ
cord-280549-bsnz24jx	806	22	lytic	lytic	JJ
cord-280549-bsnz24jx	806	23	cycle	cycle	NN
cord-280549-bsnz24jx	806	24	The	the	DT
cord-280549-bsnz24jx	806	25	J	J	NNP
cord-280549-bsnz24jx	806	26	domain	domain	NN
cord-280549-bsnz24jx	806	27	of	of	IN
cord-280549-bsnz24jx	806	28	simian	simian	JJ
cord-280549-bsnz24jx	806	29	virus	virus	NN
cord-280549-bsnz24jx	806	30	40	40	CD
cord-280549-bsnz24jx	806	31	large	large	JJ
cord-280549-bsnz24jx	806	32	T	t	NN
cord-280549-bsnz24jx	806	33	antigen	antigen	NN
cord-280549-bsnz24jx	806	34	is	be	VBZ
cord-280549-bsnz24jx	806	35	required	require	VBN
cord-280549-bsnz24jx	806	36	to	to	TO
cord-280549-bsnz24jx	806	37	functionally	functionally	RB
cord-280549-bsnz24jx	806	38	inactivate	inactivate	VB
cord-280549-bsnz24jx	806	39	RB	RB	NNP
cord-280549-bsnz24jx	806	40	family	family	NN
cord-280549-bsnz24jx	806	41	proteins	protein	NNS
cord-280549-bsnz24jx	806	42	Inactivation	Inactivation	NNP
cord-280549-bsnz24jx	806	43	of	of	IN
cord-280549-bsnz24jx	806	44	the	the	DT
cord-280549-bsnz24jx	806	45	cdk	cdk	NNP
cord-280549-bsnz24jx	806	46	inhibitor	inhibitor	NNP
cord-280549-bsnz24jx	806	47	p27KIP1	p27KIP1	NNP
cord-280549-bsnz24jx	806	48	by	by	IN
cord-280549-bsnz24jx	806	49	the	the	DT
cord-280549-bsnz24jx	806	50	human	human	JJ
cord-280549-bsnz24jx	806	51	papillomavirus	papillomavirus	NN
cord-280549-bsnz24jx	806	52	type	type	NN
cord-280549-bsnz24jx	806	53	16	16	CD
cord-280549-bsnz24jx	806	54	E7	e7	NN
cord-280549-bsnz24jx	807	1	oncoprotein	oncoprotein	NNP
cord-280549-bsnz24jx	808	1	What	what	WP
cord-280549-bsnz24jx	808	2	is	be	VBZ
cord-280549-bsnz24jx	808	3	the	the	DT
cord-280549-bsnz24jx	808	4	restriction	restriction	NN
cord-280549-bsnz24jx	808	5	point	point	NN
cord-280549-bsnz24jx	808	6	Signaling	signal	VBG
cord-280549-bsnz24jx	808	7	to	to	IN
cord-280549-bsnz24jx	808	8	p53	p53	NN
cord-280549-bsnz24jx	808	9	:	:	:
cord-280549-bsnz24jx	808	10	ribosomal	ribosomal	JJ
cord-280549-bsnz24jx	808	11	proteins	protein	NNS
cord-280549-bsnz24jx	808	12	find	find	VBP
cord-280549-bsnz24jx	808	13	their	-PRON-	PRP$
cord-280549-bsnz24jx	808	14	way	way	NN
cord-280549-bsnz24jx	808	15	Ataxia	Ataxia	NNP
cord-280549-bsnz24jx	808	16	telangiectasia	telangiectasia	NN
cord-280549-bsnz24jx	808	17	-	-	HYPH
cord-280549-bsnz24jx	808	18	mutated	mutate	VBN
cord-280549-bsnz24jx	808	19	-	-	HYPH
cord-280549-bsnz24jx	808	20	Rad3-related	rad3-relate	VBN
cord-280549-bsnz24jx	809	1	DNA	dna	NN
cord-280549-bsnz24jx	809	2	damage	damage	NN
cord-280549-bsnz24jx	809	3	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	809	4	signaling	signal	VBG
cord-280549-bsnz24jx	809	5	pathway	pathway	NN
cord-280549-bsnz24jx	809	6	triggered	trigger	VBN
cord-280549-bsnz24jx	809	7	by	by	IN
cord-280549-bsnz24jx	809	8	hepatitis	hepatitis	NNP
cord-280549-bsnz24jx	809	9	B	B	NNP
cord-280549-bsnz24jx	809	10	virus	virus	NN
cord-280549-bsnz24jx	809	11	infection	infection	NN
cord-280549-bsnz24jx	809	12	ATR	ATR	NNP
cord-280549-bsnz24jx	809	13	-	-	HYPH
cord-280549-bsnz24jx	809	14	mediated	mediate	VBN
cord-280549-bsnz24jx	809	15	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	809	16	pathways	pathway	NNS
cord-280549-bsnz24jx	809	17	regulate	regulate	VBP
cord-280549-bsnz24jx	809	18	phosphorylation	phosphorylation	NN
cord-280549-bsnz24jx	809	19	and	and	CC
cord-280549-bsnz24jx	809	20	activation	activation	NN
cord-280549-bsnz24jx	809	21	of	of	IN
cord-280549-bsnz24jx	809	22	human	human	JJ
cord-280549-bsnz24jx	809	23	Chk1	Chk1	NNP
cord-280549-bsnz24jx	809	24	Disruption	Disruption	NNP
cord-280549-bsnz24jx	809	25	of	of	IN
cord-280549-bsnz24jx	809	26	the	the	DT
cord-280549-bsnz24jx	809	27	checkpoint	checkpoint	NN
cord-280549-bsnz24jx	809	28	kinase	kinase	NN
cord-280549-bsnz24jx	809	29	1	1	CD
cord-280549-bsnz24jx	809	30	/	/	SYM
cord-280549-bsnz24jx	809	31	cell	cell	NN
cord-280549-bsnz24jx	809	32	division	division	NN
cord-280549-bsnz24jx	809	33	cycle	cycle	NN
cord-280549-bsnz24jx	810	1	25A	25A	NNP
cord-280549-bsnz24jx	810	2	pathway	pathway	NN
cord-280549-bsnz24jx	810	3	abrogates	abrogate	VBZ
cord-280549-bsnz24jx	810	4	ionizing	ionize	VBG
cord-280549-bsnz24jx	810	5	radiation	radiation	NN
cord-280549-bsnz24jx	810	6	-	-	HYPH
cord-280549-bsnz24jx	810	7	induced	induce	VBN
cord-280549-bsnz24jx	810	8	S	S	NNP
cord-280549-bsnz24jx	810	9	and	and	CC
cord-280549-bsnz24jx	810	10	G2	G2	NNP
cord-280549-bsnz24jx	810	11	checkpoints	checkpoint	NNS
cord-280549-bsnz24jx	811	1	KSHV	KSHV	NNP
cord-280549-bsnz24jx	811	2	vCyclin	vCyclin	NNP
cord-280549-bsnz24jx	811	3	counters	counter	VBZ
cord-280549-bsnz24jx	811	4	the	the	DT
cord-280549-bsnz24jx	811	5	senescence	senescence	NN
cord-280549-bsnz24jx	811	6	/	/	SYM
cord-280549-bsnz24jx	811	7	G1	G1	NNP
cord-280549-bsnz24jx	811	8	arrest	arrest	NN
cord-280549-bsnz24jx	811	9	response	response	NN
cord-280549-bsnz24jx	811	10	triggered	trigger	VBN
cord-280549-bsnz24jx	811	11	by	by	IN
cord-280549-bsnz24jx	811	12	NF	NF	NNP
cord-280549-bsnz24jx	811	13	-	-	HYPH
cord-280549-bsnz24jx	811	14	kappaB	kappaB	NNP
cord-280549-bsnz24jx	811	15	hyperactivation	hyperactivation	NN
cord-280549-bsnz24jx	811	16	Differential	differential	JJ
cord-280549-bsnz24jx	811	17	expression	expression	NN
cord-280549-bsnz24jx	811	18	,	,	,
cord-280549-bsnz24jx	811	19	localization	localization	NN
cord-280549-bsnz24jx	811	20	and	and	CC
cord-280549-bsnz24jx	811	21	activity	activity	NN
cord-280549-bsnz24jx	811	22	of	of	IN
cord-280549-bsnz24jx	811	23	two	two	CD
cord-280549-bsnz24jx	811	24	alternatively	alternatively	RB
cord-280549-bsnz24jx	811	25	spliced	splice	VBN
cord-280549-bsnz24jx	811	26	isoforms	isoform	NNS
cord-280549-bsnz24jx	811	27	of	of	IN
cord-280549-bsnz24jx	811	28	human	human	JJ
cord-280549-bsnz24jx	811	29	APC	APC	NNP
cord-280549-bsnz24jx	811	30	regulator	regulator	NN
cord-280549-bsnz24jx	811	31	CDH1	CDH1	NNP
cord-280549-bsnz24jx	811	32	Human	Human	NNP
cord-280549-bsnz24jx	811	33	immunodeficiency	immunodeficiency	NN
cord-280549-bsnz24jx	811	34	virus	virus	NN
cord-280549-bsnz24jx	811	35	type	type	NN
cord-280549-bsnz24jx	811	36	1	1	CD
cord-280549-bsnz24jx	811	37	Vpr	Vpr	NNP
cord-280549-bsnz24jx	811	38	induces	induce	VBZ
cord-280549-bsnz24jx	811	39	DNA	dna	NN
cord-280549-bsnz24jx	811	40	replication	replication	NN
cord-280549-bsnz24jx	811	41	stress	stress	NN
cord-280549-bsnz24jx	811	42	in	in	IN
cord-280549-bsnz24jx	811	43	vitro	vitro	FW
cord-280549-bsnz24jx	811	44	and	and	CC
cord-280549-bsnz24jx	811	45	in	in	IN
cord-280549-bsnz24jx	811	46	vivo	vivo	NNP
cord-280549-bsnz24jx	811	47	Identification	identification	NN
cord-280549-bsnz24jx	811	48	of	of	IN
cord-280549-bsnz24jx	811	49	a	a	DT
cord-280549-bsnz24jx	811	50	vertebrate	vertebrate	JJ
cord-280549-bsnz24jx	811	51	sister	sister	NN
cord-280549-bsnz24jx	811	52	-	-	HYPH
cord-280549-bsnz24jx	811	53	chromatid	chromatid	NN
cord-280549-bsnz24jx	811	54	separation	separation	NN
cord-280549-bsnz24jx	811	55	inhibitor	inhibitor	NN
cord-280549-bsnz24jx	811	56	involved	involve	VBN
cord-280549-bsnz24jx	811	57	in	in	IN
cord-280549-bsnz24jx	811	58	transformation	transformation	NN
cord-280549-bsnz24jx	811	59	and	and	CC
cord-280549-bsnz24jx	811	60	tumorigenesis	tumorigenesis	NN
cord-280549-bsnz24jx	811	61	Sensing	Sensing	NNP
cord-280549-bsnz24jx	811	62	DNA	dna	NN
cord-280549-bsnz24jx	811	63	damage	damage	NN
cord-280549-bsnz24jx	811	64	through	through	IN
cord-280549-bsnz24jx	811	65	ATRIP	ATRIP	NNP
cord-280549-bsnz24jx	811	66	recognition	recognition	NN
cord-280549-bsnz24jx	811	67	of	of	IN
cord-280549-bsnz24jx	811	68	RPA	RPA	NNP
cord-280549-bsnz24jx	811	69	-	-	HYPH
cord-280549-bsnz24jx	811	70	ssDNA	ssdna	NN
cord-280549-bsnz24jx	811	71	complexes	complex	NNS
cord-280549-bsnz24jx	811	72	Oncogenic	oncogenic	JJ
cord-280549-bsnz24jx	811	73	DNA	dna	NN
cord-280549-bsnz24jx	811	74	viruses	virus	NNS
cord-280549-bsnz24jx	812	1	The	the	DT
cord-280549-bsnz24jx	812	2	authors	author	NNS
cord-280549-bsnz24jx	812	3	declare	declare	VBP
cord-280549-bsnz24jx	812	4	that	that	IN
cord-280549-bsnz24jx	812	5	the	the	DT
cord-280549-bsnz24jx	812	6	research	research	NN
cord-280549-bsnz24jx	812	7	was	be	VBD
cord-280549-bsnz24jx	812	8	conducted	conduct	VBN
cord-280549-bsnz24jx	812	9	in	in	IN
cord-280549-bsnz24jx	812	10	the	the	DT
cord-280549-bsnz24jx	812	11	absence	absence	NN
cord-280549-bsnz24jx	812	12	of	of	IN
cord-280549-bsnz24jx	812	13	any	any	DT
cord-280549-bsnz24jx	812	14	commercial	commercial	JJ
cord-280549-bsnz24jx	812	15	or	or	CC
cord-280549-bsnz24jx	812	16	financial	financial	JJ
cord-280549-bsnz24jx	812	17	relationships	relationship	NNS
cord-280549-bsnz24jx	812	18	that	that	WDT
cord-280549-bsnz24jx	812	19	could	could	MD
cord-280549-bsnz24jx	812	20	be	be	VB
cord-280549-bsnz24jx	812	21	construed	construe	VBN
cord-280549-bsnz24jx	812	22	as	as	IN
cord-280549-bsnz24jx	812	23	a	a	DT
cord-280549-bsnz24jx	812	24	potential	potential	JJ
cord-280549-bsnz24jx	812	25	conflict	conflict	NN
cord-280549-bsnz24jx	812	26	of	of	IN
cord-280549-bsnz24jx	812	27	interest	interest	NN
cord-280549-bsnz24jx	812	28	.	.	.
cord-280549-bsnz24jx	813	1	Copyright	copyright	NN
cord-280549-bsnz24jx	814	1	©	©	NNP
cord-280549-bsnz24jx	814	2	2018	2018	CD
cord-280549-bsnz24jx	814	3	Fan	Fan	NNP
cord-280549-bsnz24jx	814	4	,	,	,
cord-280549-bsnz24jx	814	5	Sanyal	Sanyal	NNP
cord-280549-bsnz24jx	814	6	and	and	CC
cord-280549-bsnz24jx	814	7	Bruzzone	Bruzzone	NNP
cord-280549-bsnz24jx	814	8	.	.	.
cord-280549-bsnz24jx	815	1	This	this	DT
cord-280549-bsnz24jx	815	2	is	be	VBZ
cord-280549-bsnz24jx	815	3	an	an	DT
cord-280549-bsnz24jx	815	4	open	open	JJ
cord-280549-bsnz24jx	815	5	-	-	HYPH
cord-280549-bsnz24jx	815	6	access	access	NN
cord-280549-bsnz24jx	815	7	article	article	NN
cord-280549-bsnz24jx	815	8	distributed	distribute	VBN
cord-280549-bsnz24jx	815	9	under	under	IN
cord-280549-bsnz24jx	815	10	the	the	DT
cord-280549-bsnz24jx	815	11	terms	term	NNS
cord-280549-bsnz24jx	815	12	of	of	IN
cord-280549-bsnz24jx	815	13	the	the	DT
cord-280549-bsnz24jx	815	14	Creative	Creative	NNP
cord-280549-bsnz24jx	815	15	Commons	Commons	NNP
cord-280549-bsnz24jx	815	16	Attribution	Attribution	NNP
cord-280549-bsnz24jx	815	17	License	License	NNP
cord-280549-bsnz24jx	815	18	(	(	-LRB-
cord-280549-bsnz24jx	815	19	CC	CC	NNP
cord-280549-bsnz24jx	815	20	BY	BY	NNP
cord-280549-bsnz24jx	815	21	)	)	-RRB-
cord-280549-bsnz24jx	815	22	.	.	.
cord-280549-bsnz24jx	816	1	The	the	DT
cord-280549-bsnz24jx	816	2	use	use	NN
cord-280549-bsnz24jx	816	3	,	,	,
cord-280549-bsnz24jx	816	4	distribution	distribution	NN
cord-280549-bsnz24jx	816	5	or	or	CC
cord-280549-bsnz24jx	816	6	reproduction	reproduction	NN
cord-280549-bsnz24jx	816	7	in	in	IN
cord-280549-bsnz24jx	816	8	other	other	JJ
cord-280549-bsnz24jx	816	9	forums	forum	NNS
cord-280549-bsnz24jx	816	10	is	be	VBZ
cord-280549-bsnz24jx	816	11	permitted	permit	VBN
cord-280549-bsnz24jx	816	12	,	,	,
cord-280549-bsnz24jx	816	13	provided	provide	VBD
cord-280549-bsnz24jx	816	14	the	the	DT
cord-280549-bsnz24jx	816	15	original	original	JJ
cord-280549-bsnz24jx	816	16	author(s	author(s	NNP
cord-280549-bsnz24jx	816	17	)	)	-RRB-
cord-280549-bsnz24jx	816	18	and	and	CC
cord-280549-bsnz24jx	816	19	the	the	DT
cord-280549-bsnz24jx	816	20	copyright	copyright	NN
cord-280549-bsnz24jx	816	21	owner(s	owner(s	NNP
cord-280549-bsnz24jx	816	22	)	)	-RRB-
cord-280549-bsnz24jx	816	23	are	be	VBP
cord-280549-bsnz24jx	816	24	credited	credit	VBN
cord-280549-bsnz24jx	816	25	and	and	CC
cord-280549-bsnz24jx	816	26	that	that	IN
cord-280549-bsnz24jx	816	27	the	the	DT
cord-280549-bsnz24jx	816	28	original	original	JJ
cord-280549-bsnz24jx	816	29	publication	publication	NN
cord-280549-bsnz24jx	816	30	in	in	IN
cord-280549-bsnz24jx	816	31	this	this	DT
cord-280549-bsnz24jx	816	32	journal	journal	NN
cord-280549-bsnz24jx	816	33	is	be	VBZ
cord-280549-bsnz24jx	816	34	cited	cite	VBN
cord-280549-bsnz24jx	816	35	,	,	,
cord-280549-bsnz24jx	816	36	in	in	IN
cord-280549-bsnz24jx	816	37	accordance	accordance	NN
cord-280549-bsnz24jx	816	38	with	with	IN
cord-280549-bsnz24jx	816	39	accepted	accepted	JJ
cord-280549-bsnz24jx	816	40	academic	academic	JJ
cord-280549-bsnz24jx	816	41	practice	practice	NN
cord-280549-bsnz24jx	816	42	.	.	.
cord-280549-bsnz24jx	817	1	No	no	DT
cord-280549-bsnz24jx	817	2	use	use	NN
cord-280549-bsnz24jx	817	3	,	,	,
cord-280549-bsnz24jx	817	4	distribution	distribution	NN
cord-280549-bsnz24jx	817	5	or	or	CC
cord-280549-bsnz24jx	817	6	reproduction	reproduction	NN
cord-280549-bsnz24jx	817	7	is	be	VBZ
cord-280549-bsnz24jx	817	8	permitted	permit	VBN
cord-280549-bsnz24jx	817	9	which	which	WDT
cord-280549-bsnz24jx	817	10	does	do	VBZ
cord-280549-bsnz24jx	817	11	not	not	RB
cord-280549-bsnz24jx	817	12	comply	comply	VB
cord-280549-bsnz24jx	817	13	with	with	IN
cord-280549-bsnz24jx	817	14	these	these	DT
cord-280549-bsnz24jx	817	15	terms	term	NNS
cord-280549-bsnz24jx	817	16	.	.	.