id	sid	tid	token	lemma	pos
cord-256201-vjzfzshh	1	1	key	key	JJ
cord-256201-vjzfzshh	1	2	:	:	:
cord-256201-vjzfzshh	1	3	cord-256201-vjzfzshh	cord-256201-vjzfzshh	.
cord-256201-vjzfzshh	2	1	authors	author	NNS
cord-256201-vjzfzshh	2	2	:	:	:
cord-256201-vjzfzshh	2	3	Pereira	Pereira	NNP
cord-256201-vjzfzshh	2	4	-	-	HYPH
cord-256201-vjzfzshh	2	5	Gómez	Gómez	NNP
cord-256201-vjzfzshh	2	6	,	,	,
cord-256201-vjzfzshh	2	7	Marianoel	Marianoel	NNP
cord-256201-vjzfzshh	2	8	;	;	:
cord-256201-vjzfzshh	2	9	Sanjuán	Sanjuán	NNP
cord-256201-vjzfzshh	2	10	,	,	,
cord-256201-vjzfzshh	2	11	Rafael	Rafael	NNP
cord-256201-vjzfzshh	2	12	title	title	NN
cord-256201-vjzfzshh	2	13	:	:	:
cord-256201-vjzfzshh	2	14	Effect	effect	NN
cord-256201-vjzfzshh	2	15	of	of	IN
cord-256201-vjzfzshh	2	16	mismatch	mismatch	NN
cord-256201-vjzfzshh	2	17	repair	repair	NN
cord-256201-vjzfzshh	2	18	on	on	IN
cord-256201-vjzfzshh	2	19	the	the	DT
cord-256201-vjzfzshh	2	20	mutation	mutation	NN
cord-256201-vjzfzshh	2	21	rate	rate	NN
cord-256201-vjzfzshh	2	22	of	of	IN
cord-256201-vjzfzshh	2	23	bacteriophage	bacteriophage	NN
cord-256201-vjzfzshh	2	24	ϕX174	ϕx174	CD
cord-256201-vjzfzshh	3	1	date	date	NN
cord-256201-vjzfzshh	3	2	:	:	:
cord-256201-vjzfzshh	3	3	2015	2015	CD
cord-256201-vjzfzshh	3	4	-	-	HYPH
cord-256201-vjzfzshh	3	5	09	09	CD
cord-256201-vjzfzshh	3	6	-	-	SYM
cord-256201-vjzfzshh	3	7	10	10	CD
cord-256201-vjzfzshh	3	8	journal	journal	NN
cord-256201-vjzfzshh	3	9	:	:	:
cord-256201-vjzfzshh	4	1	Virus	Virus	NNP
cord-256201-vjzfzshh	4	2	Evol	Evol	NNP
cord-256201-vjzfzshh	4	3	DOI	DOI	NNP
cord-256201-vjzfzshh	4	4	:	:	:
cord-256201-vjzfzshh	5	1	10.1093	10.1093	CD
cord-256201-vjzfzshh	5	2	/	/	SYM
cord-256201-vjzfzshh	5	3	ve	ve	VBD
cord-256201-vjzfzshh	5	4	/	/	SYM
cord-256201-vjzfzshh	5	5	vev010	vev010	NNP
cord-256201-vjzfzshh	5	6	sha	sha	NNP
cord-256201-vjzfzshh	5	7	:	:	:
cord-256201-vjzfzshh	5	8	e1fb56142974ef2ac7aaf635398b7f0382ab9645	e1fb56142974ef2ac7aaf635398b7f0382ab9645	NNP
cord-256201-vjzfzshh	5	9	doc_id	doc_id	NNP
cord-256201-vjzfzshh	5	10	:	:	:
cord-256201-vjzfzshh	5	11	256201	256201	CD
cord-256201-vjzfzshh	5	12	cord_uid	cord_uid	NNS
cord-256201-vjzfzshh	5	13	:	:	:
cord-256201-vjzfzshh	6	1	vjzfzshh	vjzfzshh	NNP
cord-256201-vjzfzshh	6	2	Viral	Viral	NNP
cord-256201-vjzfzshh	6	3	mutation	mutation	NN
cord-256201-vjzfzshh	6	4	rates	rate	NNS
cord-256201-vjzfzshh	6	5	vary	vary	VBP
cord-256201-vjzfzshh	6	6	widely	widely	RB
cord-256201-vjzfzshh	6	7	in	in	IN
cord-256201-vjzfzshh	6	8	nature	nature	NN
cord-256201-vjzfzshh	6	9	,	,	,
cord-256201-vjzfzshh	6	10	yet	yet	CC
cord-256201-vjzfzshh	6	11	the	the	DT
cord-256201-vjzfzshh	6	12	mechanistic	mechanistic	JJ
cord-256201-vjzfzshh	6	13	and	and	CC
cord-256201-vjzfzshh	6	14	evolutionary	evolutionary	JJ
cord-256201-vjzfzshh	6	15	determinants	determinant	NNS
cord-256201-vjzfzshh	6	16	of	of	IN
cord-256201-vjzfzshh	6	17	this	this	DT
cord-256201-vjzfzshh	6	18	variability	variability	NN
cord-256201-vjzfzshh	6	19	remain	remain	VBP
cord-256201-vjzfzshh	6	20	unclear	unclear	JJ
cord-256201-vjzfzshh	6	21	.	.	.
cord-256201-vjzfzshh	7	1	Small	small	JJ
cord-256201-vjzfzshh	7	2	DNA	dna	NN
cord-256201-vjzfzshh	7	3	viruses	virus	NNS
cord-256201-vjzfzshh	7	4	mutate	mutate	VBP
cord-256201-vjzfzshh	7	5	orders	order	NNS
cord-256201-vjzfzshh	7	6	of	of	IN
cord-256201-vjzfzshh	7	7	magnitude	magnitude	NN
cord-256201-vjzfzshh	7	8	faster	fast	RBR
cord-256201-vjzfzshh	7	9	than	than	IN
cord-256201-vjzfzshh	7	10	their	-PRON-	PRP$
cord-256201-vjzfzshh	7	11	hosts	host	NNS
cord-256201-vjzfzshh	7	12	despite	despite	IN
cord-256201-vjzfzshh	7	13	using	use	VBG
cord-256201-vjzfzshh	7	14	host	host	NN
cord-256201-vjzfzshh	7	15	-	-	HYPH
cord-256201-vjzfzshh	7	16	encoded	encode	VBN
cord-256201-vjzfzshh	7	17	polymerases	polymerase	NNS
cord-256201-vjzfzshh	7	18	for	for	IN
cord-256201-vjzfzshh	7	19	replication	replication	NN
cord-256201-vjzfzshh	7	20	,	,	,
cord-256201-vjzfzshh	7	21	which	which	WDT
cord-256201-vjzfzshh	7	22	suggests	suggest	VBZ
cord-256201-vjzfzshh	7	23	these	these	DT
cord-256201-vjzfzshh	7	24	viruses	virus	NNS
cord-256201-vjzfzshh	7	25	may	may	MD
cord-256201-vjzfzshh	7	26	avoid	avoid	VB
cord-256201-vjzfzshh	7	27	post	post	JJ
cord-256201-vjzfzshh	7	28	-	-	JJ
cord-256201-vjzfzshh	7	29	replicative	replicative	JJ
cord-256201-vjzfzshh	7	30	repair	repair	NN
cord-256201-vjzfzshh	7	31	.	.	.
cord-256201-vjzfzshh	8	1	Supporting	support	VBG
cord-256201-vjzfzshh	8	2	this	this	DT
cord-256201-vjzfzshh	8	3	,	,	,
cord-256201-vjzfzshh	8	4	the	the	DT
cord-256201-vjzfzshh	8	5	genome	genome	NN
cord-256201-vjzfzshh	8	6	of	of	IN
cord-256201-vjzfzshh	8	7	bacteriophage	bacteriophage	NN
cord-256201-vjzfzshh	8	8	ϕX174	ϕX174	NFP
cord-256201-vjzfzshh	8	9	is	be	VBZ
cord-256201-vjzfzshh	8	10	completely	completely	RB
cord-256201-vjzfzshh	8	11	devoid	devoid	JJ
cord-256201-vjzfzshh	8	12	of	of	IN
cord-256201-vjzfzshh	8	13	GATC	GATC	NNP
cord-256201-vjzfzshh	8	14	sequence	sequence	NN
cord-256201-vjzfzshh	8	15	motifs	motif	NNS
cord-256201-vjzfzshh	8	16	,	,	,
cord-256201-vjzfzshh	8	17	which	which	WDT
cord-256201-vjzfzshh	8	18	are	be	VBP
cord-256201-vjzfzshh	8	19	required	require	VBN
cord-256201-vjzfzshh	8	20	for	for	IN
cord-256201-vjzfzshh	8	21	methyl	methyl	NN
cord-256201-vjzfzshh	8	22	-	-	HYPH
cord-256201-vjzfzshh	8	23	directed	direct	VBN
cord-256201-vjzfzshh	8	24	mismatch	mismatch	NN
cord-256201-vjzfzshh	8	25	repair	repair	NN
cord-256201-vjzfzshh	8	26	in	in	IN
cord-256201-vjzfzshh	8	27	Escherichia	Escherichia	NNP
cord-256201-vjzfzshh	8	28	coli	coli	NNS
cord-256201-vjzfzshh	8	29	.	.	.
cord-256201-vjzfzshh	9	1	Here	here	RB
cord-256201-vjzfzshh	9	2	,	,	,
cord-256201-vjzfzshh	9	3	we	-PRON-	PRP
cord-256201-vjzfzshh	9	4	show	show	VBP
cord-256201-vjzfzshh	9	5	that	that	IN
cord-256201-vjzfzshh	9	6	restoration	restoration	NN
cord-256201-vjzfzshh	9	7	of	of	IN
cord-256201-vjzfzshh	9	8	the	the	DT
cord-256201-vjzfzshh	9	9	randomly	randomly	RB
cord-256201-vjzfzshh	9	10	expected	expect	VBN
cord-256201-vjzfzshh	9	11	number	number	NN
cord-256201-vjzfzshh	9	12	of	of	IN
cord-256201-vjzfzshh	9	13	GATC	GATC	NNP
cord-256201-vjzfzshh	9	14	sites	site	NNS
cord-256201-vjzfzshh	9	15	leads	lead	VBZ
cord-256201-vjzfzshh	9	16	to	to	IN
cord-256201-vjzfzshh	9	17	an	an	DT
cord-256201-vjzfzshh	9	18	eightfold	eightfold	JJ
cord-256201-vjzfzshh	9	19	reduction	reduction	NN
cord-256201-vjzfzshh	9	20	in	in	IN
cord-256201-vjzfzshh	9	21	the	the	DT
cord-256201-vjzfzshh	9	22	rate	rate	NN
cord-256201-vjzfzshh	9	23	of	of	IN
cord-256201-vjzfzshh	9	24	spontaneous	spontaneous	JJ
cord-256201-vjzfzshh	9	25	mutation	mutation	NN
cord-256201-vjzfzshh	9	26	of	of	IN
cord-256201-vjzfzshh	9	27	the	the	DT
cord-256201-vjzfzshh	9	28	phage	phage	NN
cord-256201-vjzfzshh	9	29	,	,	,
cord-256201-vjzfzshh	9	30	without	without	IN
cord-256201-vjzfzshh	9	31	severely	severely	RB
cord-256201-vjzfzshh	9	32	impairing	impair	VBG
cord-256201-vjzfzshh	9	33	its	-PRON-	PRP$
cord-256201-vjzfzshh	9	34	replicative	replicative	JJ
cord-256201-vjzfzshh	9	35	capacity	capacity	NN
cord-256201-vjzfzshh	9	36	over	over	IN
cord-256201-vjzfzshh	9	37	the	the	DT
cord-256201-vjzfzshh	9	38	short	short	JJ
cord-256201-vjzfzshh	9	39	term	term	NN
cord-256201-vjzfzshh	9	40	.	.	.
cord-256201-vjzfzshh	10	1	However	however	RB
cord-256201-vjzfzshh	10	2	,	,	,
cord-256201-vjzfzshh	10	3	the	the	DT
cord-256201-vjzfzshh	10	4	efficacy	efficacy	NN
cord-256201-vjzfzshh	10	5	of	of	IN
cord-256201-vjzfzshh	10	6	mismatch	mismatch	NN
cord-256201-vjzfzshh	10	7	repair	repair	NN
cord-256201-vjzfzshh	10	8	in	in	IN
cord-256201-vjzfzshh	10	9	the	the	DT
cord-256201-vjzfzshh	10	10	presence	presence	NN
cord-256201-vjzfzshh	10	11	of	of	IN
cord-256201-vjzfzshh	10	12	GATC	GATC	NNP
cord-256201-vjzfzshh	10	13	sites	site	NNS
cord-256201-vjzfzshh	10	14	is	be	VBZ
cord-256201-vjzfzshh	10	15	limited	limit	VBN
cord-256201-vjzfzshh	10	16	by	by	IN
cord-256201-vjzfzshh	10	17	inefficient	inefficient	JJ
cord-256201-vjzfzshh	10	18	methylation	methylation	NN
cord-256201-vjzfzshh	10	19	of	of	IN
cord-256201-vjzfzshh	10	20	the	the	DT
cord-256201-vjzfzshh	10	21	viral	viral	JJ
cord-256201-vjzfzshh	10	22	DNA	dna	NN
cord-256201-vjzfzshh	10	23	.	.	.
cord-256201-vjzfzshh	11	1	Therefore	therefore	RB
cord-256201-vjzfzshh	11	2	,	,	,
cord-256201-vjzfzshh	11	3	both	both	CC
cord-256201-vjzfzshh	11	4	GATC	GATC	NNP
cord-256201-vjzfzshh	11	5	avoidance	avoidance	NN
cord-256201-vjzfzshh	11	6	and	and	CC
cord-256201-vjzfzshh	11	7	DNA	dna	NN
cord-256201-vjzfzshh	11	8	under	under	IN
cord-256201-vjzfzshh	11	9	-	-	HYPH
cord-256201-vjzfzshh	11	10	methylation	methylation	NN
cord-256201-vjzfzshh	11	11	elevate	elevate	VB
cord-256201-vjzfzshh	11	12	the	the	DT
cord-256201-vjzfzshh	11	13	mutation	mutation	NN
cord-256201-vjzfzshh	11	14	rate	rate	NN
cord-256201-vjzfzshh	11	15	of	of	IN
cord-256201-vjzfzshh	11	16	the	the	DT
cord-256201-vjzfzshh	11	17	phage	phage	NN
cord-256201-vjzfzshh	11	18	relative	relative	JJ
cord-256201-vjzfzshh	11	19	to	to	IN
cord-256201-vjzfzshh	11	20	that	that	DT
cord-256201-vjzfzshh	11	21	of	of	IN
cord-256201-vjzfzshh	11	22	the	the	DT
cord-256201-vjzfzshh	11	23	host	host	NN
cord-256201-vjzfzshh	11	24	.	.	.
cord-256201-vjzfzshh	12	1	We	-PRON-	PRP
cord-256201-vjzfzshh	12	2	also	also	RB
cord-256201-vjzfzshh	12	3	found	find	VBD
cord-256201-vjzfzshh	12	4	that	that	IN
cord-256201-vjzfzshh	12	5	the	the	DT
cord-256201-vjzfzshh	12	6	effects	effect	NNS
cord-256201-vjzfzshh	12	7	of	of	IN
cord-256201-vjzfzshh	12	8	GATC	GATC	NNP
cord-256201-vjzfzshh	12	9	sites	site	NNS
cord-256201-vjzfzshh	12	10	on	on	IN
cord-256201-vjzfzshh	12	11	the	the	DT
cord-256201-vjzfzshh	12	12	phage	phage	NN
cord-256201-vjzfzshh	12	13	mutation	mutation	NN
cord-256201-vjzfzshh	12	14	rate	rate	NN
cord-256201-vjzfzshh	12	15	vary	vary	VBP
cord-256201-vjzfzshh	12	16	extensively	extensively	RB
cord-256201-vjzfzshh	12	17	depending	depend	VBG
cord-256201-vjzfzshh	12	18	on	on	IN
cord-256201-vjzfzshh	12	19	their	-PRON-	PRP$
cord-256201-vjzfzshh	12	20	specific	specific	JJ
cord-256201-vjzfzshh	12	21	location	location	NN
cord-256201-vjzfzshh	12	22	within	within	IN
cord-256201-vjzfzshh	12	23	the	the	DT
cord-256201-vjzfzshh	12	24	phage	phage	NN
cord-256201-vjzfzshh	12	25	genome	genome	NN
cord-256201-vjzfzshh	12	26	.	.	.
cord-256201-vjzfzshh	13	1	Finally	finally	RB
cord-256201-vjzfzshh	13	2	,	,	,
cord-256201-vjzfzshh	13	3	the	the	DT
cord-256201-vjzfzshh	13	4	mutation	mutation	NN
cord-256201-vjzfzshh	13	5	rate	rate	NN
cord-256201-vjzfzshh	13	6	reduction	reduction	NN
cord-256201-vjzfzshh	13	7	afforded	afford	VBN
cord-256201-vjzfzshh	13	8	by	by	IN
cord-256201-vjzfzshh	13	9	GATC	GATC	NNP
cord-256201-vjzfzshh	13	10	sites	site	NNS
cord-256201-vjzfzshh	13	11	is	be	VBZ
cord-256201-vjzfzshh	13	12	fully	fully	RB
cord-256201-vjzfzshh	13	13	reverted	revert	VBN
cord-256201-vjzfzshh	13	14	under	under	IN
cord-256201-vjzfzshh	13	15	stress	stress	NN
cord-256201-vjzfzshh	13	16	conditions	condition	NNS
cord-256201-vjzfzshh	13	17	,	,	,
cord-256201-vjzfzshh	13	18	which	which	WDT
cord-256201-vjzfzshh	13	19	up	up	RB
cord-256201-vjzfzshh	13	20	-	-	HYPH
cord-256201-vjzfzshh	13	21	regulate	regulate	VB
cord-256201-vjzfzshh	13	22	repair	repair	NN
cord-256201-vjzfzshh	13	23	pathways	pathway	NNS
cord-256201-vjzfzshh	13	24	and	and	CC
cord-256201-vjzfzshh	13	25	expression	expression	NN
cord-256201-vjzfzshh	13	26	of	of	IN
cord-256201-vjzfzshh	13	27	error	error	NN
cord-256201-vjzfzshh	13	28	-	-	HYPH
cord-256201-vjzfzshh	13	29	prone	prone	JJ
cord-256201-vjzfzshh	13	30	host	host	NN
cord-256201-vjzfzshh	13	31	polymerases	polymerase	NNS
cord-256201-vjzfzshh	13	32	such	such	JJ
cord-256201-vjzfzshh	13	33	as	as	IN
cord-256201-vjzfzshh	13	34	heat	heat	NN
cord-256201-vjzfzshh	13	35	and	and	CC
cord-256201-vjzfzshh	13	36	treatment	treatment	NN
cord-256201-vjzfzshh	13	37	with	with	IN
cord-256201-vjzfzshh	13	38	the	the	DT
cord-256201-vjzfzshh	13	39	base	base	NN
cord-256201-vjzfzshh	13	40	analog	analog	NN
cord-256201-vjzfzshh	13	41	5-fluorouracil	5-fluorouracil	CD
cord-256201-vjzfzshh	13	42	,	,	,
cord-256201-vjzfzshh	13	43	suggesting	suggest	VBG
cord-256201-vjzfzshh	13	44	that	that	IN
cord-256201-vjzfzshh	13	45	access	access	NN
cord-256201-vjzfzshh	13	46	to	to	IN
cord-256201-vjzfzshh	13	47	repair	repair	NN
cord-256201-vjzfzshh	13	48	renders	render	VBZ
cord-256201-vjzfzshh	13	49	the	the	DT
cord-256201-vjzfzshh	13	50	phage	phage	NN
cord-256201-vjzfzshh	13	51	sensitive	sensitive	JJ
cord-256201-vjzfzshh	13	52	to	to	IN
cord-256201-vjzfzshh	13	53	stress	stress	NN
cord-256201-vjzfzshh	13	54	-	-	HYPH
cord-256201-vjzfzshh	13	55	induced	induce	VBN
cord-256201-vjzfzshh	13	56	mutagenesis	mutagenesis	NN
cord-256201-vjzfzshh	13	57	.	.	.
cord-256201-vjzfzshh	14	1	Mutation	mutation	NN
cord-256201-vjzfzshh	14	2	is	be	VBZ
cord-256201-vjzfzshh	14	3	the	the	DT
cord-256201-vjzfzshh	14	4	ultimate	ultimate	JJ
cord-256201-vjzfzshh	14	5	source	source	NN
cord-256201-vjzfzshh	14	6	of	of	IN
cord-256201-vjzfzshh	14	7	genetic	genetic	JJ
cord-256201-vjzfzshh	14	8	variation	variation	NN
cord-256201-vjzfzshh	14	9	and	and	CC
cord-256201-vjzfzshh	14	10	,	,	,
cord-256201-vjzfzshh	14	11	therefore	therefore	RB
cord-256201-vjzfzshh	14	12	,	,	,
cord-256201-vjzfzshh	14	13	a	a	DT
cord-256201-vjzfzshh	14	14	central	central	JJ
cord-256201-vjzfzshh	14	15	evolutionary	evolutionary	JJ
cord-256201-vjzfzshh	14	16	process	process	NN
cord-256201-vjzfzshh	14	17	.	.	.
cord-256201-vjzfzshh	15	1	Although	although	IN
cord-256201-vjzfzshh	15	2	mutations	mutation	NNS
cord-256201-vjzfzshh	15	3	are	be	VBP
cord-256201-vjzfzshh	15	4	required	require	VBN
cord-256201-vjzfzshh	15	5	for	for	IN
cord-256201-vjzfzshh	15	6	adaptation	adaptation	NN
cord-256201-vjzfzshh	15	7	,	,	,
cord-256201-vjzfzshh	15	8	the	the	DT
cord-256201-vjzfzshh	15	9	short	short	JJ
cord-256201-vjzfzshh	15	10	-	-	HYPH
cord-256201-vjzfzshh	15	11	term	term	NN
cord-256201-vjzfzshh	15	12	deleteriousness	deleteriousness	NN
cord-256201-vjzfzshh	15	13	of	of	IN
cord-256201-vjzfzshh	15	14	most	most	JJS
cord-256201-vjzfzshh	15	15	spontaneous	spontaneous	JJ
cord-256201-vjzfzshh	15	16	mutations	mutation	NNS
cord-256201-vjzfzshh	15	17	should	should	MD
cord-256201-vjzfzshh	15	18	generally	generally	RB
cord-256201-vjzfzshh	15	19	favor	favor	VB
cord-256201-vjzfzshh	15	20	low	low	JJ
cord-256201-vjzfzshh	15	21	mutation	mutation	NN
cord-256201-vjzfzshh	15	22	rates	rate	NNS
cord-256201-vjzfzshh	15	23	(	(	-LRB-
cord-256201-vjzfzshh	15	24	Sniegowski	Sniegowski	NNP
cord-256201-vjzfzshh	15	25	et	et	NNP
cord-256201-vjzfzshh	15	26	al	al	NNP
cord-256201-vjzfzshh	15	27	.	.	.
cord-256201-vjzfzshh	15	28	2000	2000	CD
cord-256201-vjzfzshh	15	29	)	)	-RRB-
cord-256201-vjzfzshh	15	30	.	.	.
cord-256201-vjzfzshh	16	1	In	in	IN
cord-256201-vjzfzshh	16	2	theory	theory	NN
cord-256201-vjzfzshh	16	3	,	,	,
cord-256201-vjzfzshh	16	4	the	the	DT
cord-256201-vjzfzshh	16	5	balance	balance	NN
cord-256201-vjzfzshh	16	6	between	between	IN
cord-256201-vjzfzshh	16	7	these	these	DT
cord-256201-vjzfzshh	16	8	short	short	JJ
cord-256201-vjzfzshh	16	9	-	-	HYPH
cord-256201-vjzfzshh	16	10	term	term	NN
cord-256201-vjzfzshh	16	11	costs	cost	NNS
cord-256201-vjzfzshh	16	12	and	and	CC
cord-256201-vjzfzshh	16	13	the	the	DT
cord-256201-vjzfzshh	16	14	long	long	JJ
cord-256201-vjzfzshh	16	15	-	-	HYPH
cord-256201-vjzfzshh	16	16	term	term	NN
cord-256201-vjzfzshh	16	17	benefits	benefit	NNS
cord-256201-vjzfzshh	16	18	for	for	IN
cord-256201-vjzfzshh	16	19	adaptation	adaptation	NN
cord-256201-vjzfzshh	16	20	should	should	MD
cord-256201-vjzfzshh	16	21	produce	produce	VB
cord-256201-vjzfzshh	16	22	an	an	DT
cord-256201-vjzfzshh	16	23	evolutionarily	evolutionarily	RB
cord-256201-vjzfzshh	16	24	optimal	optimal	JJ
cord-256201-vjzfzshh	16	25	,	,	,
cord-256201-vjzfzshh	16	26	intermediate	intermediate	JJ
cord-256201-vjzfzshh	16	27	mutation	mutation	NN
cord-256201-vjzfzshh	16	28	rate	rate	NN
cord-256201-vjzfzshh	16	29	which	which	WDT
cord-256201-vjzfzshh	16	30	is	be	VBZ
cord-256201-vjzfzshh	16	31	dependent	dependent	JJ
cord-256201-vjzfzshh	16	32	on	on	IN
cord-256201-vjzfzshh	16	33	selection	selection	NN
cord-256201-vjzfzshh	16	34	strength	strength	NN
cord-256201-vjzfzshh	16	35	(	(	-LRB-
cord-256201-vjzfzshh	16	36	Orr	Orr	NNP
cord-256201-vjzfzshh	16	37	2000	2000	CD
cord-256201-vjzfzshh	16	38	;	;	:
cord-256201-vjzfzshh	16	39	Johnson	Johnson	NNP
cord-256201-vjzfzshh	16	40	and	and	CC
cord-256201-vjzfzshh	16	41	Barton	Barton	NNP
cord-256201-vjzfzshh	16	42	2002	2002	CD
cord-256201-vjzfzshh	16	43	)	)	-RRB-
cord-256201-vjzfzshh	16	44	.	.	.
cord-256201-vjzfzshh	17	1	Other	other	JJ
cord-256201-vjzfzshh	17	2	factors	factor	NNS
cord-256201-vjzfzshh	17	3	can	can	MD
cord-256201-vjzfzshh	17	4	also	also	RB
cord-256201-vjzfzshh	17	5	determine	determine	VB
cord-256201-vjzfzshh	17	6	mutation	mutation	NN
cord-256201-vjzfzshh	17	7	rate	rate	NN
cord-256201-vjzfzshh	17	8	evolution	evolution	NN
cord-256201-vjzfzshh	17	9	,	,	,
cord-256201-vjzfzshh	17	10	including	include	VBG
cord-256201-vjzfzshh	17	11	the	the	DT
cord-256201-vjzfzshh	17	12	costs	cost	NNS
cord-256201-vjzfzshh	17	13	of	of	IN
cord-256201-vjzfzshh	17	14	maintaining	maintain	VBG
cord-256201-vjzfzshh	17	15	mechanisms	mechanism	NNS
cord-256201-vjzfzshh	17	16	of	of	IN
cord-256201-vjzfzshh	17	17	replication	replication	NN
cord-256201-vjzfzshh	17	18	fidelity	fidelity	NN
cord-256201-vjzfzshh	17	19	,	,	,
cord-256201-vjzfzshh	17	20	population	population	NN
cord-256201-vjzfzshh	17	21	size	size	NN
cord-256201-vjzfzshh	17	22	,	,	,
cord-256201-vjzfzshh	17	23	and	and	CC
cord-256201-vjzfzshh	17	24	structure	structure	NN
cord-256201-vjzfzshh	17	25	,	,	,
cord-256201-vjzfzshh	17	26	or	or	CC
cord-256201-vjzfzshh	17	27	the	the	DT
cord-256201-vjzfzshh	17	28	topology	topology	NN
cord-256201-vjzfzshh	17	29	of	of	IN
cord-256201-vjzfzshh	17	30	the	the	DT
cord-256201-vjzfzshh	17	31	fitness	fitness	NN
cord-256201-vjzfzshh	17	32	landscape	landscape	NN
cord-256201-vjzfzshh	17	33	among	among	IN
cord-256201-vjzfzshh	17	34	others	other	NNS
cord-256201-vjzfzshh	17	35	(	(	-LRB-
cord-256201-vjzfzshh	17	36	André	André	NNP
cord-256201-vjzfzshh	17	37	and	and	CC
cord-256201-vjzfzshh	17	38	Godelle	Godelle	NNP
cord-256201-vjzfzshh	17	39	2006	2006	CD
cord-256201-vjzfzshh	17	40	;	;	:
cord-256201-vjzfzshh	17	41	Clune	Clune	NNP
cord-256201-vjzfzshh	17	42	et	et	NNP
cord-256201-vjzfzshh	17	43	al	al	NNP
cord-256201-vjzfzshh	17	44	.	.	NNP
cord-256201-vjzfzshh	17	45	2008	2008	CD
cord-256201-vjzfzshh	17	46	;	;	:
cord-256201-vjzfzshh	17	47	Jiang	Jiang	NNP
cord-256201-vjzfzshh	17	48	et	et	FW
cord-256201-vjzfzshh	17	49	al	al	NNP
cord-256201-vjzfzshh	17	50	.	.	NNP
cord-256201-vjzfzshh	17	51	2010	2010	CD
cord-256201-vjzfzshh	17	52	;	;	:
cord-256201-vjzfzshh	17	53	Lynch	Lynch	NNP
cord-256201-vjzfzshh	17	54	2011	2011	CD
cord-256201-vjzfzshh	17	55	;	;	:
cord-256201-vjzfzshh	17	56	Sung	Sung	NNP
cord-256201-vjzfzshh	17	57	et	et	NNP
cord-256201-vjzfzshh	17	58	al	al	NNP
cord-256201-vjzfzshh	17	59	.	.	NNP
cord-256201-vjzfzshh	17	60	2012	2012	CD
cord-256201-vjzfzshh	17	61	)	)	-RRB-
cord-256201-vjzfzshh	17	62	.	.	.
cord-256201-vjzfzshh	18	1	Despite	despite	IN
cord-256201-vjzfzshh	18	2	this	this	DT
cord-256201-vjzfzshh	18	3	variety	variety	NN
cord-256201-vjzfzshh	18	4	of	of	IN
cord-256201-vjzfzshh	18	5	factors	factor	NNS
cord-256201-vjzfzshh	18	6	,	,	,
cord-256201-vjzfzshh	18	7	it	-PRON-	PRP
cord-256201-vjzfzshh	18	8	has	have	VBZ
cord-256201-vjzfzshh	18	9	been	be	VBN
cord-256201-vjzfzshh	18	10	noted	note	VBN
cord-256201-vjzfzshh	18	11	that	that	IN
cord-256201-vjzfzshh	18	12	genomic	genomic	JJ
cord-256201-vjzfzshh	18	13	mutation	mutation	NN
cord-256201-vjzfzshh	18	14	rates	rate	NNS
cord-256201-vjzfzshh	18	15	stay	stay	VBP
cord-256201-vjzfzshh	18	16	remarkably	remarkably	RB
cord-256201-vjzfzshh	18	17	constant	constant	JJ
cord-256201-vjzfzshh	18	18	among	among	IN
cord-256201-vjzfzshh	18	19	DNA	dna	NN
cord-256201-vjzfzshh	18	20	viruses	virus	NNS
cord-256201-vjzfzshh	18	21	,	,	,
cord-256201-vjzfzshh	18	22	bacteria	bacteria	NNS
cord-256201-vjzfzshh	18	23	,	,	,
cord-256201-vjzfzshh	18	24	and	and	CC
cord-256201-vjzfzshh	18	25	unicellular	unicellular	JJ
cord-256201-vjzfzshh	18	26	eukaryotes	eukaryote	NNS
cord-256201-vjzfzshh	18	27	(	(	-LRB-
cord-256201-vjzfzshh	18	28	Drake	Drake	NNP
cord-256201-vjzfzshh	18	29	1991	1991	CD
cord-256201-vjzfzshh	18	30	;	;	:
cord-256201-vjzfzshh	18	31	Drake	Drake	NNP
cord-256201-vjzfzshh	18	32	et	et	NNP
cord-256201-vjzfzshh	18	33	al	al	NNP
cord-256201-vjzfzshh	18	34	.	.	NNP
cord-256201-vjzfzshh	18	35	1998	1998	CD
cord-256201-vjzfzshh	18	36	)	)	-RRB-
cord-256201-vjzfzshh	18	37	.	.	.
cord-256201-vjzfzshh	19	1	As	as	IN
cord-256201-vjzfzshh	19	2	a	a	DT
cord-256201-vjzfzshh	19	3	consequence	consequence	NN
cord-256201-vjzfzshh	19	4	,	,	,
cord-256201-vjzfzshh	19	5	pernucleotide	pernucleotide	NN
cord-256201-vjzfzshh	19	6	rates	rate	NNS
cord-256201-vjzfzshh	19	7	vary	vary	VBP
cord-256201-vjzfzshh	19	8	by	by	IN
cord-256201-vjzfzshh	19	9	10,000-fold	10,000-fold	CD
cord-256201-vjzfzshh	19	10	and	and	CC
cord-256201-vjzfzshh	19	11	inversely	inversely	RB
cord-256201-vjzfzshh	19	12	with	with	IN
cord-256201-vjzfzshh	19	13	genome	genome	NN
cord-256201-vjzfzshh	19	14	size	size	NN
cord-256201-vjzfzshh	19	15	,	,	,
cord-256201-vjzfzshh	19	16	from	from	IN
cord-256201-vjzfzshh	19	17	10	10	CD
cord-256201-vjzfzshh	19	18	-6	-6	CD
cord-256201-vjzfzshh	19	19	to	to	IN
cord-256201-vjzfzshh	19	20	10	10	CD
cord-256201-vjzfzshh	19	21	-10	-10	NN
cord-256201-vjzfzshh	19	22	mutations	mutation	NNS
cord-256201-vjzfzshh	19	23	per	per	IN
cord-256201-vjzfzshh	19	24	nucleotide	nucleotide	NN
cord-256201-vjzfzshh	19	25	per	per	IN
cord-256201-vjzfzshh	19	26	round	round	NN
cord-256201-vjzfzshh	19	27	of	of	IN
cord-256201-vjzfzshh	19	28	copying	copying	NN
cord-256201-vjzfzshh	19	29	(	(	-LRB-
cord-256201-vjzfzshh	19	30	m	m	NNP
cord-256201-vjzfzshh	19	31	/	/	SYM
cord-256201-vjzfzshh	19	32	n	n	NN
cord-256201-vjzfzshh	19	33	/	/	SYM
cord-256201-vjzfzshh	19	34	r	r	NN
cord-256201-vjzfzshh	19	35	)	)	-RRB-
cord-256201-vjzfzshh	19	36	(	(	-LRB-
cord-256201-vjzfzshh	19	37	Lynch	Lynch	NNP
cord-256201-vjzfzshh	19	38	2010	2010	CD
cord-256201-vjzfzshh	19	39	)	)	-RRB-
cord-256201-vjzfzshh	19	40	.	.	.
cord-256201-vjzfzshh	20	1	How	how	WRB
cord-256201-vjzfzshh	20	2	evolutionary	evolutionary	JJ
cord-256201-vjzfzshh	20	3	forces	force	NNS
cord-256201-vjzfzshh	20	4	have	have	VBP
cord-256201-vjzfzshh	20	5	shaped	shape	VBN
cord-256201-vjzfzshh	20	6	this	this	DT
cord-256201-vjzfzshh	20	7	inverse	inverse	JJ
cord-256201-vjzfzshh	20	8	relationship	relationship	NN
cord-256201-vjzfzshh	20	9	in	in	IN
cord-256201-vjzfzshh	20	10	such	such	JJ
cord-256201-vjzfzshh	20	11	widely	widely	RB
cord-256201-vjzfzshh	20	12	different	different	JJ
cord-256201-vjzfzshh	20	13	microbial	microbial	JJ
cord-256201-vjzfzshh	20	14	systems	system	NNS
cord-256201-vjzfzshh	20	15	and	and	CC
cord-256201-vjzfzshh	20	16	which	which	WDT
cord-256201-vjzfzshh	20	17	molecular	molecular	JJ
cord-256201-vjzfzshh	20	18	mechanisms	mechanism	NNS
cord-256201-vjzfzshh	20	19	allow	allow	VBP
cord-256201-vjzfzshh	20	20	for	for	IN
cord-256201-vjzfzshh	20	21	this	this	DT
cord-256201-vjzfzshh	20	22	mutation	mutation	NN
cord-256201-vjzfzshh	20	23	rate	rate	NN
cord-256201-vjzfzshh	20	24	variation	variation	NN
cord-256201-vjzfzshh	20	25	remain	remain	VBP
cord-256201-vjzfzshh	20	26	poorly	poorly	RB
cord-256201-vjzfzshh	20	27	understood	understand	VBN
cord-256201-vjzfzshh	20	28	questions	question	NNS
cord-256201-vjzfzshh	20	29	.	.	.
cord-256201-vjzfzshh	21	1	For	for	IN
cord-256201-vjzfzshh	21	2	DNA	dna	NN
cord-256201-vjzfzshh	21	3	viruses	virus	NNS
cord-256201-vjzfzshh	21	4	,	,	,
cord-256201-vjzfzshh	21	5	mutation	mutation	NN
cord-256201-vjzfzshh	21	6	rates	rate	NNS
cord-256201-vjzfzshh	21	7	range	range	VBP
cord-256201-vjzfzshh	21	8	from	from	IN
cord-256201-vjzfzshh	21	9	10	10	CD
cord-256201-vjzfzshh	21	10	-8	-8	NNPS
cord-256201-vjzfzshh	21	11	m	m	NNP
cord-256201-vjzfzshh	21	12	/	/	SYM
cord-256201-vjzfzshh	21	13	n	n	NNP
cord-256201-vjzfzshh	21	14	/	/	SYM
cord-256201-vjzfzshh	21	15	r	r	NN
cord-256201-vjzfzshh	21	16	in	in	IN
cord-256201-vjzfzshh	21	17	double	double	RB
cord-256201-vjzfzshh	21	18	-	-	HYPH
cord-256201-vjzfzshh	21	19	stranded	stranded	JJ
cord-256201-vjzfzshh	21	20	(	(	-LRB-
cord-256201-vjzfzshh	21	21	ds	ds	NNP
cord-256201-vjzfzshh	21	22	)	)	-RRB-
cord-256201-vjzfzshh	21	23	DNA	dna	NN
cord-256201-vjzfzshh	21	24	viruses	virus	NNS
cord-256201-vjzfzshh	21	25	such	such	JJ
cord-256201-vjzfzshh	21	26	as	as	IN
cord-256201-vjzfzshh	21	27	herpes	herpe	NNS
cord-256201-vjzfzshh	21	28	virus	virus	NN
cord-256201-vjzfzshh	21	29	to	to	IN
cord-256201-vjzfzshh	21	30	10	10	CD
cord-256201-vjzfzshh	21	31	-6	-6	NNP
cord-256201-vjzfzshh	21	32	m	m	NNP
cord-256201-vjzfzshh	21	33	/	/	SYM
cord-256201-vjzfzshh	21	34	n	n	NNP
cord-256201-vjzfzshh	21	35	/	/	SYM
cord-256201-vjzfzshh	21	36	r	r	NN
cord-256201-vjzfzshh	21	37	in	in	IN
cord-256201-vjzfzshh	21	38	single	single	RB
cord-256201-vjzfzshh	21	39	-	-	HYPH
cord-256201-vjzfzshh	21	40	stranded	stranded	JJ
cord-256201-vjzfzshh	21	41	(	(	-LRB-
cord-256201-vjzfzshh	21	42	ss	ss	NNP
cord-256201-vjzfzshh	21	43	)	)	-RRB-
cord-256201-vjzfzshh	21	44	DNA	dna	NN
cord-256201-vjzfzshh	21	45	viruses	virus	NNS
cord-256201-vjzfzshh	21	46	such	such	JJ
cord-256201-vjzfzshh	21	47	as	as	IN
cord-256201-vjzfzshh	21	48	bacteriophage	bacteriophage	NN
cord-256201-vjzfzshh	21	49	/X174	/X174	NFP
cord-256201-vjzfzshh	21	50	,	,	,
cord-256201-vjzfzshh	21	51	whereas	whereas	IN
cord-256201-vjzfzshh	21	52	these	these	DT
cord-256201-vjzfzshh	21	53	rates	rate	NNS
cord-256201-vjzfzshh	21	54	range	range	VBP
cord-256201-vjzfzshh	21	55	from	from	IN
cord-256201-vjzfzshh	21	56	10	10	CD
cord-256201-vjzfzshh	21	57	-6	-6	CD
cord-256201-vjzfzshh	21	58	to	to	IN
cord-256201-vjzfzshh	21	59	10	10	CD
cord-256201-vjzfzshh	21	60	-4	-4	NNS
cord-256201-vjzfzshh	21	61	m	m	NNP
cord-256201-vjzfzshh	21	62	/	/	SYM
cord-256201-vjzfzshh	21	63	n	n	NN
cord-256201-vjzfzshh	21	64	/	/	SYM
cord-256201-vjzfzshh	21	65	r	r	NN
cord-256201-vjzfzshh	21	66	in	in	IN
cord-256201-vjzfzshh	21	67	RNA	RNA	NNP
cord-256201-vjzfzshh	21	68	viruses	virus	NNS
cord-256201-vjzfzshh	22	1	(	(	-LRB-
cord-256201-vjzfzshh	22	2	Sanjuá	Sanjuá	NNP
cord-256201-vjzfzshh	22	3	n	n	NNP
cord-256201-vjzfzshh	22	4	et	et	NNP
cord-256201-vjzfzshh	22	5	al	al	NNP
cord-256201-vjzfzshh	22	6	.	.	NNP
cord-256201-vjzfzshh	22	7	2010	2010	CD
cord-256201-vjzfzshh	22	8	)	)	-RRB-
cord-256201-vjzfzshh	22	9	.	.	.
cord-256201-vjzfzshh	23	1	A	a	DT
cord-256201-vjzfzshh	23	2	primary	primary	JJ
cord-256201-vjzfzshh	23	3	determinant	determinant	NN
cord-256201-vjzfzshh	23	4	of	of	IN
cord-256201-vjzfzshh	23	5	viral	viral	JJ
cord-256201-vjzfzshh	23	6	mutation	mutation	NN
cord-256201-vjzfzshh	23	7	rates	rate	NNS
cord-256201-vjzfzshh	23	8	is	be	VBZ
cord-256201-vjzfzshh	23	9	replication	replication	NN
cord-256201-vjzfzshh	23	10	fidelity	fidelity	NN
cord-256201-vjzfzshh	23	11	,	,	,
cord-256201-vjzfzshh	23	12	and	and	CC
cord-256201-vjzfzshh	23	13	polymerase	polymerase	NN
cord-256201-vjzfzshh	23	14	variants	variant	NNS
cord-256201-vjzfzshh	23	15	with	with	IN
cord-256201-vjzfzshh	23	16	altered	alter	VBN
cord-256201-vjzfzshh	23	17	base	base	NN
cord-256201-vjzfzshh	23	18	-	-	HYPH
cord-256201-vjzfzshh	23	19	selection	selection	NN
cord-256201-vjzfzshh	23	20	specificities	specificity	NNS
cord-256201-vjzfzshh	23	21	have	have	VBP
cord-256201-vjzfzshh	23	22	been	be	VBN
cord-256201-vjzfzshh	23	23	described	describe	VBN
cord-256201-vjzfzshh	23	24	in	in	IN
cord-256201-vjzfzshh	23	25	several	several	JJ
cord-256201-vjzfzshh	23	26	RNA	RNA	NNP
cord-256201-vjzfzshh	23	27	viruses	virus	NNS
cord-256201-vjzfzshh	23	28	including	include	VBG
cord-256201-vjzfzshh	23	29	picornaviruses	picornavirus	NNS
cord-256201-vjzfzshh	23	30	,	,	,
cord-256201-vjzfzshh	23	31	alphaviruses	alphaviruses	NNP
cord-256201-vjzfzshh	23	32	,	,	,
cord-256201-vjzfzshh	23	33	and	and	CC
cord-256201-vjzfzshh	23	34	retroviruses	retrovirus	NNS
cord-256201-vjzfzshh	23	35	.	.	.
cord-256201-vjzfzshh	24	1	However	however	RB
cord-256201-vjzfzshh	24	2	,	,	,
cord-256201-vjzfzshh	24	3	fidelity	fidelity	NN
cord-256201-vjzfzshh	24	4	variants	variant	NNS
cord-256201-vjzfzshh	24	5	that	that	WDT
cord-256201-vjzfzshh	24	6	are	be	VBP
cord-256201-vjzfzshh	24	7	not	not	RB
cord-256201-vjzfzshh	24	8	lethal	lethal	JJ
cord-256201-vjzfzshh	24	9	typically	typically	RB
cord-256201-vjzfzshh	24	10	alter	alter	VB
cord-256201-vjzfzshh	24	11	mutation	mutation	NN
cord-256201-vjzfzshh	24	12	rates	rate	NNS
cord-256201-vjzfzshh	24	13	only	only	RB
cord-256201-vjzfzshh	24	14	slightly	slightly	RB
cord-256201-vjzfzshh	24	15	(	(	-LRB-
cord-256201-vjzfzshh	24	16	Pfeiffer	Pfeiffer	NNP
cord-256201-vjzfzshh	24	17	and	and	CC
cord-256201-vjzfzshh	24	18	Kirkegaard	Kirkegaard	NNP
cord-256201-vjzfzshh	24	19	2003	2003	CD
cord-256201-vjzfzshh	24	20	;	;	:
cord-256201-vjzfzshh	24	21	Arias	Arias	NNP
cord-256201-vjzfzshh	24	22	et	et	FW
cord-256201-vjzfzshh	24	23	al	al	NNP
cord-256201-vjzfzshh	24	24	.	.	NNP
cord-256201-vjzfzshh	24	25	2008	2008	CD
cord-256201-vjzfzshh	24	26	;	;	:
cord-256201-vjzfzshh	24	27	Mené	Mené	NNP
cord-256201-vjzfzshh	24	28	ndez	ndez	NNP
cord-256201-vjzfzshh	24	29	-	-	HYPH
cord-256201-vjzfzshh	24	30	Arias	Arias	NNP
cord-256201-vjzfzshh	24	31	2009	2009	CD
cord-256201-vjzfzshh	24	32	;	;	:
cord-256201-vjzfzshh	24	33	Coffey	Coffey	NNP
cord-256201-vjzfzshh	24	34	et	et	NNP
cord-256201-vjzfzshh	24	35	al	al	NNP
cord-256201-vjzfzshh	24	36	.	.	NNP
cord-256201-vjzfzshh	24	37	2011	2011	CD
cord-256201-vjzfzshh	24	38	;	;	:
cord-256201-vjzfzshh	24	39	Graci	Graci	NNP
cord-256201-vjzfzshh	24	40	et	et	NNP
cord-256201-vjzfzshh	24	41	al	al	NNP
cord-256201-vjzfzshh	24	42	.	.	NNP
cord-256201-vjzfzshh	24	43	2012	2012	CD
cord-256201-vjzfzshh	24	44	)	)	-RRB-
cord-256201-vjzfzshh	24	45	.	.	.
cord-256201-vjzfzshh	25	1	The	the	DT
cord-256201-vjzfzshh	25	2	presence	presence	NN
cord-256201-vjzfzshh	25	3	of	of	IN
cord-256201-vjzfzshh	25	4	3	3	CD
cord-256201-vjzfzshh	25	5	exonuclease	exonuclease	NN
cord-256201-vjzfzshh	25	6	proofreading	proofreading	NN
cord-256201-vjzfzshh	25	7	has	have	VBZ
cord-256201-vjzfzshh	25	8	a	a	DT
cord-256201-vjzfzshh	25	9	stronger	strong	JJR
cord-256201-vjzfzshh	25	10	effect	effect	NN
cord-256201-vjzfzshh	25	11	on	on	IN
cord-256201-vjzfzshh	25	12	viral	viral	JJ
cord-256201-vjzfzshh	25	13	replication	replication	NN
cord-256201-vjzfzshh	25	14	fidelity	fidelity	NN
cord-256201-vjzfzshh	25	15	.	.	.
cord-256201-vjzfzshh	26	1	All	all	DT
cord-256201-vjzfzshh	26	2	RNAdependent	RNAdependent	NNP
cord-256201-vjzfzshh	26	3	polymerases	polymerases	VBP
cord-256201-vjzfzshh	26	4	except	except	IN
cord-256201-vjzfzshh	26	5	those	those	DT
cord-256201-vjzfzshh	26	6	of	of	IN
cord-256201-vjzfzshh	26	7	coronaviruses	coronaviruse	NNS
cord-256201-vjzfzshh	26	8	lack	lack	VBP
cord-256201-vjzfzshh	26	9	3	3	CD
cord-256201-vjzfzshh	26	10	'	'	''
cord-256201-vjzfzshh	26	11	exonuclease	exonuclease	NN
cord-256201-vjzfzshh	26	12	activity	activity	NN
cord-256201-vjzfzshh	26	13	,	,	,
cord-256201-vjzfzshh	26	14	as	as	IN
cord-256201-vjzfzshh	26	15	opposed	oppose	VBN
cord-256201-vjzfzshh	26	16	to	to	IN
cord-256201-vjzfzshh	26	17	virus	virus	NN
cord-256201-vjzfzshh	26	18	-	-	HYPH
cord-256201-vjzfzshh	26	19	encoded	encode	VBN
cord-256201-vjzfzshh	26	20	DNA	dna	NN
cord-256201-vjzfzshh	26	21	polymerases	polymerase	NNS
cord-256201-vjzfzshh	26	22	,	,	,
cord-256201-vjzfzshh	26	23	therefore	therefore	RB
cord-256201-vjzfzshh	26	24	providing	provide	VBG
cord-256201-vjzfzshh	26	25	a	a	DT
cord-256201-vjzfzshh	26	26	clear	clear	JJ
cord-256201-vjzfzshh	26	27	basis	basis	NN
cord-256201-vjzfzshh	26	28	for	for	IN
cord-256201-vjzfzshh	26	29	the	the	DT
cord-256201-vjzfzshh	26	30	higher	high	JJR
cord-256201-vjzfzshh	26	31	mutation	mutation	NN
cord-256201-vjzfzshh	26	32	rates	rate	NNS
cord-256201-vjzfzshh	26	33	of	of	IN
cord-256201-vjzfzshh	26	34	RNA	RNA	NNP
cord-256201-vjzfzshh	26	35	viruses	virus	NNS
cord-256201-vjzfzshh	26	36	compared	compare	VBN
cord-256201-vjzfzshh	26	37	with	with	IN
cord-256201-vjzfzshh	26	38	DNA	dna	NN
cord-256201-vjzfzshh	26	39	viruses	virus	NNS
cord-256201-vjzfzshh	26	40	(	(	-LRB-
cord-256201-vjzfzshh	26	41	Roberts	Roberts	NNP
cord-256201-vjzfzshh	26	42	,	,	,
cord-256201-vjzfzshh	26	43	Bebenek	Bebenek	NNP
cord-256201-vjzfzshh	26	44	,	,	,
cord-256201-vjzfzshh	26	45	and	and	CC
cord-256201-vjzfzshh	26	46	Kunkel	Kunkel	NNP
cord-256201-vjzfzshh	26	47	1988	1988	CD
cord-256201-vjzfzshh	26	48	;	;	:
cord-256201-vjzfzshh	26	49	Steinhauer	Steinhauer	NNP
cord-256201-vjzfzshh	26	50	,	,	,
cord-256201-vjzfzshh	26	51	Domingo	Domingo	NNP
cord-256201-vjzfzshh	26	52	,	,	,
cord-256201-vjzfzshh	26	53	and	and	CC
cord-256201-vjzfzshh	26	54	Holland	Holland	NNP
cord-256201-vjzfzshh	26	55	1992	1992	CD
cord-256201-vjzfzshh	26	56	;	;	:
cord-256201-vjzfzshh	26	57	Mené	Mené	NNP
cord-256201-vjzfzshh	26	58	ndez	ndez	NNP
cord-256201-vjzfzshh	26	59	-	-	HYPH
cord-256201-vjzfzshh	26	60	Arias	Arias	NNP
cord-256201-vjzfzshh	26	61	2009	2009	CD
cord-256201-vjzfzshh	26	62	;	;	:
cord-256201-vjzfzshh	26	63	Denison	Denison	NNP
cord-256201-vjzfzshh	26	64	et	et	NNP
cord-256201-vjzfzshh	26	65	al	al	NNP
cord-256201-vjzfzshh	26	66	.	.	NNP
cord-256201-vjzfzshh	26	67	2011	2011	CD
cord-256201-vjzfzshh	26	68	;	;	:
cord-256201-vjzfzshh	26	69	Smith	Smith	NNP
cord-256201-vjzfzshh	26	70	et	et	NNP
cord-256201-vjzfzshh	26	71	al	al	NNP
cord-256201-vjzfzshh	26	72	.	.	NNP
cord-256201-vjzfzshh	26	73	2013	2013	CD
cord-256201-vjzfzshh	26	74	)	)	-RRB-
cord-256201-vjzfzshh	26	75	.	.	.
cord-256201-vjzfzshh	27	1	In	in	IN
cord-256201-vjzfzshh	27	2	addition	addition	NN
cord-256201-vjzfzshh	27	3	to	to	TO
cord-256201-vjzfzshh	27	4	polymerase	polymerase	VB
cord-256201-vjzfzshh	27	5	fidelity	fidelity	NN
cord-256201-vjzfzshh	27	6	,	,	,
cord-256201-vjzfzshh	27	7	in	in	IN
cord-256201-vjzfzshh	27	8	DNA	dna	NN
cord-256201-vjzfzshh	27	9	viruses	virus	NNS
cord-256201-vjzfzshh	27	10	,	,	,
cord-256201-vjzfzshh	27	11	mutation	mutation	NN
cord-256201-vjzfzshh	27	12	rates	rate	NNS
cord-256201-vjzfzshh	27	13	should	should	MD
cord-256201-vjzfzshh	27	14	be	be	VB
cord-256201-vjzfzshh	27	15	determined	determine	VBN
cord-256201-vjzfzshh	27	16	by	by	IN
cord-256201-vjzfzshh	27	17	their	-PRON-	PRP$
cord-256201-vjzfzshh	27	18	ability	ability	NN
cord-256201-vjzfzshh	27	19	to	to	TO
cord-256201-vjzfzshh	27	20	access	access	VB
cord-256201-vjzfzshh	27	21	postreplicative	postreplicative	NNP
cord-256201-vjzfzshh	27	22	repair	repair	NN
cord-256201-vjzfzshh	27	23	.	.	.
cord-256201-vjzfzshh	28	1	In	in	IN
cord-256201-vjzfzshh	28	2	ssDNA	ssdna	JJ
cord-256201-vjzfzshh	28	3	bacteriophages	bacteriophage	NNS
cord-256201-vjzfzshh	28	4	such	such	JJ
cord-256201-vjzfzshh	28	5	as	as	IN
cord-256201-vjzfzshh	28	6	/X174	/X174	NNP
cord-256201-vjzfzshh	28	7	or	or	CC
cord-256201-vjzfzshh	28	8	m13	m13	CD
cord-256201-vjzfzshh	28	9	,	,	,
cord-256201-vjzfzshh	28	10	replication	replication	NN
cord-256201-vjzfzshh	28	11	is	be	VBZ
cord-256201-vjzfzshh	28	12	carried	carry	VBN
cord-256201-vjzfzshh	28	13	out	out	RP
cord-256201-vjzfzshh	28	14	by	by	IN
cord-256201-vjzfzshh	28	15	the	the	DT
cord-256201-vjzfzshh	28	16	Escherichia	Escherichia	NNP
cord-256201-vjzfzshh	28	17	coli	coli	NNS
cord-256201-vjzfzshh	28	18	DNA	DNA	NNP
cord-256201-vjzfzshh	28	19	III	iii	CD
cord-256201-vjzfzshh	28	20	holoenzyme	holoenzyme	NNS
cord-256201-vjzfzshh	28	21	,	,	,
cord-256201-vjzfzshh	28	22	which	which	WDT
cord-256201-vjzfzshh	28	23	exhibits	exhibit	VBZ
cord-256201-vjzfzshh	28	24	similar	similar	JJ
cord-256201-vjzfzshh	28	25	fidelity	fidelity	NN
cord-256201-vjzfzshh	28	26	in	in	IN
cord-256201-vjzfzshh	28	27	phage	phage	NN
cord-256201-vjzfzshh	28	28	and	and	CC
cord-256201-vjzfzshh	28	29	host	host	NN
cord-256201-vjzfzshh	28	30	templates	template	NNS
cord-256201-vjzfzshh	28	31	(	(	-LRB-
cord-256201-vjzfzshh	28	32	Fersht	Fersht	NNP
cord-256201-vjzfzshh	28	33	1979	1979	CD
cord-256201-vjzfzshh	28	34	;	;	:
cord-256201-vjzfzshh	28	35	Fersht	Fersht	NNP
cord-256201-vjzfzshh	28	36	and	and	CC
cord-256201-vjzfzshh	28	37	Knill	Knill	NNP
cord-256201-vjzfzshh	28	38	-	-	HYPH
cord-256201-vjzfzshh	28	39	Jones	Jones	NNP
cord-256201-vjzfzshh	28	40	1981	1981	CD
cord-256201-vjzfzshh	28	41	)	)	-RRB-
cord-256201-vjzfzshh	28	42	.	.	.
cord-256201-vjzfzshh	29	1	However	however	RB
cord-256201-vjzfzshh	29	2	,	,	,
cord-256201-vjzfzshh	29	3	these	these	DT
cord-256201-vjzfzshh	29	4	phages	phage	NNS
cord-256201-vjzfzshh	29	5	show	show	VBP
cord-256201-vjzfzshh	29	6	a	a	DT
cord-256201-vjzfzshh	29	7	mutation	mutation	NN
cord-256201-vjzfzshh	29	8	rate	rate	NN
cord-256201-vjzfzshh	29	9	approximately	approximately	RB
cord-256201-vjzfzshh	29	10	three	three	CD
cord-256201-vjzfzshh	29	11	orders	order	NNS
cord-256201-vjzfzshh	29	12	of	of	IN
cord-256201-vjzfzshh	29	13	magnitude	magnitude	NN
cord-256201-vjzfzshh	29	14	higher	high	JJR
cord-256201-vjzfzshh	29	15	than	than	IN
cord-256201-vjzfzshh	29	16	the	the	DT
cord-256201-vjzfzshh	29	17	host	host	NN
cord-256201-vjzfzshh	29	18	(	(	-LRB-
cord-256201-vjzfzshh	29	19	Wickner	Wickner	NNP
cord-256201-vjzfzshh	29	20	and	and	CC
cord-256201-vjzfzshh	29	21	Hurwitz	Hurwitz	NNP
cord-256201-vjzfzshh	29	22	1974	1974	CD
cord-256201-vjzfzshh	29	23	;	;	:
cord-256201-vjzfzshh	29	24	Raney	Raney	NNP
cord-256201-vjzfzshh	29	25	,	,	,
cord-256201-vjzfzshh	29	26	Delongchamp	Delongchamp	NNP
cord-256201-vjzfzshh	29	27	,	,	,
cord-256201-vjzfzshh	29	28	and	and	CC
cord-256201-vjzfzshh	29	29	Valentine	Valentine	NNP
cord-256201-vjzfzshh	29	30	2004	2004	CD
cord-256201-vjzfzshh	29	31	;	;	:
cord-256201-vjzfzshh	29	32	Cuevas	Cuevas	NNP
cord-256201-vjzfzshh	29	33	,	,	,
cord-256201-vjzfzshh	29	34	Duffy	Duffy	NNP
cord-256201-vjzfzshh	29	35	,	,	,
cord-256201-vjzfzshh	29	36	and	and	CC
cord-256201-vjzfzshh	29	37	Sanjuá	Sanjuá	NNP
cord-256201-vjzfzshh	29	38	n	n	NNP
cord-256201-vjzfzshh	29	39	2009	2009	CD
cord-256201-vjzfzshh	29	40	)	)	-RRB-
cord-256201-vjzfzshh	29	41	.	.	.
cord-256201-vjzfzshh	30	1	The	the	DT
cord-256201-vjzfzshh	30	2	high	high	JJ
cord-256201-vjzfzshh	30	3	variability	variability	NN
cord-256201-vjzfzshh	30	4	and	and	CC
cord-256201-vjzfzshh	30	5	fast	fast	JJ
cord-256201-vjzfzshh	30	6	evolution	evolution	NN
cord-256201-vjzfzshh	30	7	of	of	IN
cord-256201-vjzfzshh	30	8	small	small	JJ
cord-256201-vjzfzshh	30	9	eukaryotic	eukaryotic	JJ
cord-256201-vjzfzshh	30	10	DNA	dna	NN
cord-256201-vjzfzshh	30	11	viruses	virus	NNS
cord-256201-vjzfzshh	30	12	such	such	JJ
cord-256201-vjzfzshh	30	13	as	as	IN
cord-256201-vjzfzshh	30	14	parvoviruses	parvovirus	NNS
cord-256201-vjzfzshh	30	15	and	and	CC
cord-256201-vjzfzshh	30	16	polyomaviruses	polyomaviruse	NNS
cord-256201-vjzfzshh	30	17	similarly	similarly	RB
cord-256201-vjzfzshh	30	18	suggests	suggest	VBZ
cord-256201-vjzfzshh	30	19	elevated	elevated	JJ
cord-256201-vjzfzshh	30	20	rates	rate	NNS
cord-256201-vjzfzshh	30	21	of	of	IN
cord-256201-vjzfzshh	30	22	spontaneous	spontaneous	JJ
cord-256201-vjzfzshh	30	23	mutation	mutation	NN
cord-256201-vjzfzshh	30	24	(	(	-LRB-
cord-256201-vjzfzshh	30	25	Duffy	Duffy	NNP
cord-256201-vjzfzshh	30	26	,	,	,
cord-256201-vjzfzshh	30	27	Shackelton	Shackelton	NNP
cord-256201-vjzfzshh	30	28	,	,	,
cord-256201-vjzfzshh	30	29	and	and	CC
cord-256201-vjzfzshh	30	30	Holmes	Holmes	NNP
cord-256201-vjzfzshh	30	31	2008	2008	CD
cord-256201-vjzfzshh	30	32	)	)	-RRB-
cord-256201-vjzfzshh	30	33	.	.	.
cord-256201-vjzfzshh	31	1	The	the	DT
cord-256201-vjzfzshh	31	2	efficiency	efficiency	NN
cord-256201-vjzfzshh	31	3	of	of	IN
cord-256201-vjzfzshh	31	4	post	post	JJ
cord-256201-vjzfzshh	31	5	-	-	JJ
cord-256201-vjzfzshh	31	6	replicative	replicative	JJ
cord-256201-vjzfzshh	31	7	repair	repair	NN
cord-256201-vjzfzshh	31	8	can	can	MD
cord-256201-vjzfzshh	31	9	be	be	VB
cord-256201-vjzfzshh	31	10	higher	high	JJR
cord-256201-vjzfzshh	31	11	than	than	IN
cord-256201-vjzfzshh	31	12	99	99	CD
cord-256201-vjzfzshh	31	13	per	per	IN
cord-256201-vjzfzshh	31	14	cent	cent	NN
cord-256201-vjzfzshh	31	15	(	(	-LRB-
cord-256201-vjzfzshh	31	16	Fijalkowska	Fijalkowska	NNP
cord-256201-vjzfzshh	31	17	,	,	,
cord-256201-vjzfzshh	31	18	Schaaper	Schaaper	NNP
cord-256201-vjzfzshh	31	19	,	,	,
cord-256201-vjzfzshh	31	20	and	and	CC
cord-256201-vjzfzshh	31	21	Jonczyk	Jonczyk	NNP
cord-256201-vjzfzshh	31	22	2012	2012	CD
cord-256201-vjzfzshh	31	23	)	)	-RRB-
cord-256201-vjzfzshh	31	24	.	.	.
cord-256201-vjzfzshh	32	1	In	in	IN
cord-256201-vjzfzshh	32	2	E.	E.	NNP
cord-256201-vjzfzshh	32	3	coli	coli	NNS
cord-256201-vjzfzshh	32	4	,	,	,
cord-256201-vjzfzshh	32	5	strand	strand	NN
cord-256201-vjzfzshh	32	6	-	-	HYPH
cord-256201-vjzfzshh	32	7	specific	specific	JJ
cord-256201-vjzfzshh	32	8	bidirectional	bidirectional	JJ
cord-256201-vjzfzshh	32	9	methyl	methyl	NN
cord-256201-vjzfzshh	32	10	-	-	HYPH
cord-256201-vjzfzshh	32	11	directed	direct	VBN
cord-256201-vjzfzshh	32	12	mismatch	mismatch	NN
cord-256201-vjzfzshh	32	13	repair	repair	NN
cord-256201-vjzfzshh	32	14	(	(	-LRB-
cord-256201-vjzfzshh	32	15	MMR	MMR	NNP
cord-256201-vjzfzshh	32	16	)	)	-RRB-
cord-256201-vjzfzshh	32	17	is	be	VBZ
cord-256201-vjzfzshh	32	18	performed	perform	VBN
cord-256201-vjzfzshh	32	19	by	by	IN
cord-256201-vjzfzshh	32	20	the	the	DT
cord-256201-vjzfzshh	32	21	Dam	Dam	NNP
cord-256201-vjzfzshh	32	22	/	/	SYM
cord-256201-vjzfzshh	32	23	MutHLS	muthls	NN
cord-256201-vjzfzshh	32	24	system	system	NN
cord-256201-vjzfzshh	32	25	(	(	-LRB-
cord-256201-vjzfzshh	32	26	Jiricny	Jiricny	NNP
cord-256201-vjzfzshh	32	27	2013	2013	CD
cord-256201-vjzfzshh	32	28	)	)	-RRB-
cord-256201-vjzfzshh	32	29	.	.	.
cord-256201-vjzfzshh	33	1	Point	point	NN
cord-256201-vjzfzshh	33	2	mutations	mutation	NNS
cord-256201-vjzfzshh	33	3	or	or	CC
cord-256201-vjzfzshh	33	4	small	small	JJ
cord-256201-vjzfzshh	33	5	insertion	insertion	NN
cord-256201-vjzfzshh	33	6	/	/	SYM
cord-256201-vjzfzshh	33	7	deletion	deletion	NN
cord-256201-vjzfzshh	33	8	loops	loop	NNS
cord-256201-vjzfzshh	33	9	are	be	VBP
cord-256201-vjzfzshh	33	10	recognized	recognize	VBN
cord-256201-vjzfzshh	33	11	by	by	IN
cord-256201-vjzfzshh	33	12	MutS	MutS	NNP
cord-256201-vjzfzshh	33	13	,	,	,
cord-256201-vjzfzshh	33	14	which	which	WDT
cord-256201-vjzfzshh	33	15	interacts	interact	VBZ
cord-256201-vjzfzshh	33	16	with	with	IN
cord-256201-vjzfzshh	33	17	MutL	MutL	NNP
cord-256201-vjzfzshh	33	18	,	,	,
cord-256201-vjzfzshh	33	19	leading	lead	VBG
cord-256201-vjzfzshh	33	20	to	to	IN
cord-256201-vjzfzshh	33	21	activation	activation	NN
cord-256201-vjzfzshh	33	22	of	of	IN
cord-256201-vjzfzshh	33	23	the	the	DT
cord-256201-vjzfzshh	33	24	MutH	MutH	NNP
cord-256201-vjzfzshh	33	25	endonuclease	endonuclease	NN
cord-256201-vjzfzshh	33	26	.	.	.
cord-256201-vjzfzshh	34	1	The	the	DT
cord-256201-vjzfzshh	34	2	latter	latter	NN
cord-256201-vjzfzshh	34	3	recognizes	recognize	VBZ
cord-256201-vjzfzshh	34	4	the	the	DT
cord-256201-vjzfzshh	34	5	parental	parental	JJ
cord-256201-vjzfzshh	34	6	strand	strand	NN
cord-256201-vjzfzshh	34	7	by	by	IN
cord-256201-vjzfzshh	34	8	the	the	DT
cord-256201-vjzfzshh	34	9	presence	presence	NN
cord-256201-vjzfzshh	34	10	of	of	IN
cord-256201-vjzfzshh	34	11	a	a	DT
cord-256201-vjzfzshh	34	12	methyl	methyl	NN
cord-256201-vjzfzshh	34	13	group	group	NN
cord-256201-vjzfzshh	34	14	in	in	IN
cord-256201-vjzfzshh	34	15	the	the	DT
cord-256201-vjzfzshh	34	16	adenosine	adenosine	NN
cord-256201-vjzfzshh	34	17	of	of	IN
cord-256201-vjzfzshh	34	18	a	a	DT
cord-256201-vjzfzshh	34	19	GATC	GATC	NNP
cord-256201-vjzfzshh	34	20	sequence	sequence	NN
cord-256201-vjzfzshh	34	21	motif	motif	NN
cord-256201-vjzfzshh	34	22	located	locate	VBN
cord-256201-vjzfzshh	34	23	on	on	IN
cord-256201-vjzfzshh	34	24	either	either	DT
cord-256201-vjzfzshh	34	25	side	side	NN
cord-256201-vjzfzshh	34	26	of	of	IN
cord-256201-vjzfzshh	34	27	the	the	DT
cord-256201-vjzfzshh	34	28	mismatch	mismatch	NN
cord-256201-vjzfzshh	34	29	,	,	,
cord-256201-vjzfzshh	34	30	which	which	WDT
cord-256201-vjzfzshh	34	31	has	have	VBZ
cord-256201-vjzfzshh	34	32	been	be	VBN
cord-256201-vjzfzshh	34	33	previously	previously	RB
cord-256201-vjzfzshh	34	34	added	add	VBN
cord-256201-vjzfzshh	34	35	by	by	IN
cord-256201-vjzfzshh	34	36	Dam	Dam	NNP
cord-256201-vjzfzshh	34	37	methylase	methylase	NN
cord-256201-vjzfzshh	34	38	.	.	.
cord-256201-vjzfzshh	35	1	MutH	MutH	NNP
cord-256201-vjzfzshh	35	2	then	then	RB
cord-256201-vjzfzshh	35	3	cleaves	cleave	VBZ
cord-256201-vjzfzshh	35	4	the	the	DT
cord-256201-vjzfzshh	35	5	non	non	JJ
cord-256201-vjzfzshh	35	6	-	-	JJ
cord-256201-vjzfzshh	35	7	methylated	methylated	JJ
cord-256201-vjzfzshh	35	8	daughter	daughter	NN
cord-256201-vjzfzshh	35	9	strand	strand	NN
cord-256201-vjzfzshh	35	10	,	,	,
cord-256201-vjzfzshh	35	11	which	which	WDT
cord-256201-vjzfzshh	35	12	is	be	VBZ
cord-256201-vjzfzshh	35	13	degraded	degrade	VBN
cord-256201-vjzfzshh	35	14	and	and	CC
cord-256201-vjzfzshh	35	15	re	re	VBN
cord-256201-vjzfzshh	35	16	-	-	JJ
cord-256201-vjzfzshh	35	17	synthesized	synthesize	VBN
cord-256201-vjzfzshh	35	18	(	(	-LRB-
cord-256201-vjzfzshh	35	19	Modrich	Modrich	NNP
cord-256201-vjzfzshh	35	20	and	and	CC
cord-256201-vjzfzshh	35	21	Lahue	Lahue	NNP
cord-256201-vjzfzshh	35	22	1996	1996	CD
cord-256201-vjzfzshh	35	23	;	;	:
cord-256201-vjzfzshh	35	24	Marti	Marti	NNP
cord-256201-vjzfzshh	35	25	,	,	,
cord-256201-vjzfzshh	35	26	Kunz	Kunz	NNP
cord-256201-vjzfzshh	35	27	,	,	,
cord-256201-vjzfzshh	35	28	and	and	CC
cord-256201-vjzfzshh	35	29	Fleck	Fleck	NNP
cord-256201-vjzfzshh	35	30	2002	2002	CD
cord-256201-vjzfzshh	35	31	;	;	:
cord-256201-vjzfzshh	35	32	Schofield	Schofield	NNP
cord-256201-vjzfzshh	35	33	and	and	CC
cord-256201-vjzfzshh	35	34	Hsieh	Hsieh	NNP
cord-256201-vjzfzshh	35	35	2003	2003	CD
cord-256201-vjzfzshh	35	36	;	;	:
cord-256201-vjzfzshh	35	37	Li	Li	NNP
cord-256201-vjzfzshh	35	38	2008	2008	CD
cord-256201-vjzfzshh	35	39	;	;	:
cord-256201-vjzfzshh	35	40	Fukui	Fukui	NNP
cord-256201-vjzfzshh	35	41	2010	2010	CD
cord-256201-vjzfzshh	35	42	)	)	-RRB-
cord-256201-vjzfzshh	35	43	.	.	.
cord-256201-vjzfzshh	36	1	Strikingly	strikingly	RB
cord-256201-vjzfzshh	36	2	,	,	,
cord-256201-vjzfzshh	36	3	though	though	RB
cord-256201-vjzfzshh	36	4	,	,	,
cord-256201-vjzfzshh	36	5	the	the	DT
cord-256201-vjzfzshh	36	6	5.4	5.4	CD
cord-256201-vjzfzshh	36	7	kb	kb	NNP
cord-256201-vjzfzshh	36	8	genome	genome	NN
cord-256201-vjzfzshh	36	9	of	of	IN
cord-256201-vjzfzshh	36	10	bacteriophage	bacteriophage	NN
cord-256201-vjzfzshh	36	11	/X174	/X174	,
cord-256201-vjzfzshh	36	12	contains	contain	VBZ
cord-256201-vjzfzshh	36	13	no	no	DT
cord-256201-vjzfzshh	36	14	GATC	GATC	NNP
cord-256201-vjzfzshh	36	15	sites	site	NNS
cord-256201-vjzfzshh	36	16	,	,	,
cord-256201-vjzfzshh	36	17	whereas	whereas	IN
cord-256201-vjzfzshh	36	18	the	the	DT
cord-256201-vjzfzshh	36	19	randomly	randomly	RB
cord-256201-vjzfzshh	36	20	expected	expect	VBN
cord-256201-vjzfzshh	36	21	number	number	NN
cord-256201-vjzfzshh	36	22	of	of	IN
cord-256201-vjzfzshh	36	23	such	such	JJ
cord-256201-vjzfzshh	36	24	sequences	sequence	NNS
cord-256201-vjzfzshh	36	25	given	give	VBN
cord-256201-vjzfzshh	36	26	the	the	DT
cord-256201-vjzfzshh	36	27	/X174	/X174	NFP
cord-256201-vjzfzshh	36	28	genome	genome	NN
cord-256201-vjzfzshh	36	29	size	size	NN
cord-256201-vjzfzshh	36	30	and	and	CC
cord-256201-vjzfzshh	36	31	base	base	NN
cord-256201-vjzfzshh	36	32	composition	composition	NN
cord-256201-vjzfzshh	36	33	is	be	VBZ
cord-256201-vjzfzshh	36	34	approximately	approximately	RB
cord-256201-vjzfzshh	36	35	20	20	CD
cord-256201-vjzfzshh	36	36	.	.	.
cord-256201-vjzfzshh	37	1	By	by	IN
cord-256201-vjzfzshh	37	2	impeding	impede	VBG
cord-256201-vjzfzshh	37	3	Dam	Dam	NNP
cord-256201-vjzfzshh	37	4	methylation	methylation	NN
cord-256201-vjzfzshh	37	5	,	,	,
cord-256201-vjzfzshh	37	6	the	the	DT
cord-256201-vjzfzshh	37	7	lack	lack	NN
cord-256201-vjzfzshh	37	8	of	of	IN
cord-256201-vjzfzshh	37	9	GATC	GATC	NNP
cord-256201-vjzfzshh	37	10	sites	site	NNS
cord-256201-vjzfzshh	37	11	therefore	therefore	RB
cord-256201-vjzfzshh	37	12	avoids	avoid	VBZ
cord-256201-vjzfzshh	37	13	a	a	DT
cord-256201-vjzfzshh	37	14	major	major	JJ
cord-256201-vjzfzshh	37	15	repair	repair	NN
cord-256201-vjzfzshh	37	16	pathway	pathway	NN
cord-256201-vjzfzshh	37	17	.	.	.
cord-256201-vjzfzshh	38	1	However	however	RB
cord-256201-vjzfzshh	38	2	,	,	,
cord-256201-vjzfzshh	38	3	the	the	DT
cord-256201-vjzfzshh	38	4	impact	impact	NN
cord-256201-vjzfzshh	38	5	of	of	IN
cord-256201-vjzfzshh	38	6	GATC	GATC	NNP
cord-256201-vjzfzshh	38	7	motifs	motif	NNS
cord-256201-vjzfzshh	38	8	on	on	IN
cord-256201-vjzfzshh	38	9	the	the	DT
cord-256201-vjzfzshh	38	10	phage	phage	NN
cord-256201-vjzfzshh	38	11	mutation	mutation	NN
cord-256201-vjzfzshh	38	12	rate	rate	NN
cord-256201-vjzfzshh	38	13	is	be	VBZ
cord-256201-vjzfzshh	38	14	still	still	RB
cord-256201-vjzfzshh	38	15	poorly	poorly	RB
cord-256201-vjzfzshh	38	16	understood	understand	VBN
cord-256201-vjzfzshh	38	17	.	.	.
cord-256201-vjzfzshh	39	1	In	in	IN
cord-256201-vjzfzshh	39	2	a	a	DT
cord-256201-vjzfzshh	39	3	previous	previous	JJ
cord-256201-vjzfzshh	39	4	study	study	NN
cord-256201-vjzfzshh	39	5	(	(	-LRB-
cord-256201-vjzfzshh	39	6	Cuevas	Cuevas	NNP
cord-256201-vjzfzshh	39	7	,	,	,
cord-256201-vjzfzshh	39	8	Pereira	Pereira	NNP
cord-256201-vjzfzshh	39	9	-	-	HYPH
cord-256201-vjzfzshh	39	10	Gomez	Gomez	NNP
cord-256201-vjzfzshh	39	11	,	,	,
cord-256201-vjzfzshh	39	12	and	and	CC
cord-256201-vjzfzshh	39	13	Sanjuá	Sanjuá	NNP
cord-256201-vjzfzshh	39	14	n	n	NNP
cord-256201-vjzfzshh	39	15	2011	2011	CD
cord-256201-vjzfzshh	39	16	)	)	-RRB-
cord-256201-vjzfzshh	39	17	,	,	,
cord-256201-vjzfzshh	39	18	we	-PRON-	PRP
cord-256201-vjzfzshh	39	19	introduced	introduce	VBD
cord-256201-vjzfzshh	39	20	four	four	CD
cord-256201-vjzfzshh	39	21	GATC	GATC	NNP
cord-256201-vjzfzshh	39	22	sequence	sequence	NN
cord-256201-vjzfzshh	39	23	motifs	motif	NNS
cord-256201-vjzfzshh	39	24	in	in	IN
cord-256201-vjzfzshh	39	25	the	the	DT
cord-256201-vjzfzshh	39	26	/X174	/X174	NFP
cord-256201-vjzfzshh	39	27	genome	genome	NN
cord-256201-vjzfzshh	39	28	and	and	CC
cord-256201-vjzfzshh	39	29	found	find	VBD
cord-256201-vjzfzshh	39	30	no	no	DT
cord-256201-vjzfzshh	39	31	effects	effect	NNS
cord-256201-vjzfzshh	39	32	on	on	IN
cord-256201-vjzfzshh	39	33	mutation	mutation	NN
cord-256201-vjzfzshh	39	34	rate	rate	NN
cord-256201-vjzfzshh	39	35	.	.	.
cord-256201-vjzfzshh	40	1	However	however	RB
cord-256201-vjzfzshh	40	2	,	,	,
cord-256201-vjzfzshh	40	3	by	by	IN
cord-256201-vjzfzshh	40	4	increasing	increase	VBG
cord-256201-vjzfzshh	40	5	the	the	DT
cord-256201-vjzfzshh	40	6	number	number	NN
cord-256201-vjzfzshh	40	7	of	of	IN
cord-256201-vjzfzshh	40	8	GATC	GATC	NNP
cord-256201-vjzfzshh	40	9	motifs	motif	NNS
cord-256201-vjzfzshh	40	10	to	to	IN
cord-256201-vjzfzshh	40	11	seven	seven	CD
cord-256201-vjzfzshh	40	12	,	,	,
cord-256201-vjzfzshh	40	13	we	-PRON-	PRP
cord-256201-vjzfzshh	40	14	obtained	obtain	VBD
cord-256201-vjzfzshh	40	15	a	a	DT
cord-256201-vjzfzshh	40	16	thirtyfold	thirtyfold	JJ
cord-256201-vjzfzshh	40	17	reduction	reduction	NN
cord-256201-vjzfzshh	40	18	in	in	IN
cord-256201-vjzfzshh	40	19	mutation	mutation	NN
cord-256201-vjzfzshh	40	20	rate	rate	NN
cord-256201-vjzfzshh	40	21	.	.	.
cord-256201-vjzfzshh	41	1	Furthermore	furthermore	RB
cord-256201-vjzfzshh	41	2	,	,	,
cord-256201-vjzfzshh	41	3	this	this	DT
cord-256201-vjzfzshh	41	4	effect	effect	NN
cord-256201-vjzfzshh	41	5	was	be	VBD
cord-256201-vjzfzshh	41	6	reverted	revert	VBN
cord-256201-vjzfzshh	41	7	in	in	IN
cord-256201-vjzfzshh	41	8	MMRdeficient	mmrdeficient	NN
cord-256201-vjzfzshh	41	9	mutD	mutd	NN
cord-256201-vjzfzshh	41	10	cells	cell	NNS
cord-256201-vjzfzshh	41	11	,	,	,
cord-256201-vjzfzshh	41	12	indicating	indicate	VBG
cord-256201-vjzfzshh	41	13	that	that	IN
cord-256201-vjzfzshh	41	14	the	the	DT
cord-256201-vjzfzshh	41	15	effects	effect	NNS
cord-256201-vjzfzshh	41	16	of	of	IN
cord-256201-vjzfzshh	41	17	GATC	GATC	NNP
cord-256201-vjzfzshh	41	18	motifs	motif	NNS
cord-256201-vjzfzshh	41	19	were	be	VBD
cord-256201-vjzfzshh	41	20	related	relate	VBN
cord-256201-vjzfzshh	41	21	to	to	IN
cord-256201-vjzfzshh	41	22	MMR	MMR	NNP
cord-256201-vjzfzshh	41	23	.	.	.
cord-256201-vjzfzshh	42	1	Here	here	RB
cord-256201-vjzfzshh	42	2	,	,	,
cord-256201-vjzfzshh	42	3	to	to	TO
cord-256201-vjzfzshh	42	4	better	better	RB
cord-256201-vjzfzshh	42	5	explore	explore	VB
cord-256201-vjzfzshh	42	6	how	how	WRB
cord-256201-vjzfzshh	42	7	MMR	MMR	NNP
cord-256201-vjzfzshh	42	8	avoidance	avoidance	NN
cord-256201-vjzfzshh	42	9	determines	determine	VBZ
cord-256201-vjzfzshh	42	10	the	the	DT
cord-256201-vjzfzshh	42	11	mutation	mutation	NN
cord-256201-vjzfzshh	42	12	rate	rate	NN
cord-256201-vjzfzshh	42	13	of	of	IN
cord-256201-vjzfzshh	42	14	/X174	/X174	.
cord-256201-vjzfzshh	43	1	,	,	,
cord-256201-vjzfzshh	43	2	we	-PRON-	PRP
cord-256201-vjzfzshh	43	3	constructed	construct	VBD
cord-256201-vjzfzshh	43	4	a	a	DT
cord-256201-vjzfzshh	43	5	/X174	/x174	CD
cord-256201-vjzfzshh	43	6	variant	variant	NN
cord-256201-vjzfzshh	43	7	encoding	encode	VBG
cord-256201-vjzfzshh	43	8	twenty	twenty	CD
cord-256201-vjzfzshh	43	9	randomly	randomly	RB
cord-256201-vjzfzshh	43	10	located	locate	VBN
cord-256201-vjzfzshh	43	11	GATCs	gatcs	VBP
cord-256201-vjzfzshh	43	12	with	with	IN
cord-256201-vjzfzshh	43	13	minimal	minimal	JJ
cord-256201-vjzfzshh	43	14	effects	effect	NNS
cord-256201-vjzfzshh	43	15	on	on	IN
cord-256201-vjzfzshh	43	16	protein	protein	NN
cord-256201-vjzfzshh	43	17	sequence	sequence	NN
cord-256201-vjzfzshh	43	18	.	.	.
cord-256201-vjzfzshh	44	1	The	the	DT
cord-256201-vjzfzshh	44	2	engineered	engineer	VBN
cord-256201-vjzfzshh	44	3	phage	phage	NN
cord-256201-vjzfzshh	44	4	showed	show	VBD
cord-256201-vjzfzshh	44	5	an	an	DT
cord-256201-vjzfzshh	44	6	eightfold	eightfold	JJ
cord-256201-vjzfzshh	44	7	reduction	reduction	NN
cord-256201-vjzfzshh	44	8	in	in	IN
cord-256201-vjzfzshh	44	9	spontaneous	spontaneous	JJ
cord-256201-vjzfzshh	44	10	mutation	mutation	NN
cord-256201-vjzfzshh	44	11	rate	rate	NN
cord-256201-vjzfzshh	44	12	compared	compare	VBN
cord-256201-vjzfzshh	44	13	with	with	IN
cord-256201-vjzfzshh	44	14	the	the	DT
cord-256201-vjzfzshh	44	15	wild	wild	JJ
cord-256201-vjzfzshh	44	16	type	type	NN
cord-256201-vjzfzshh	44	17	(	(	-LRB-
cord-256201-vjzfzshh	44	18	WT	WT	NNP
cord-256201-vjzfzshh	44	19	)	)	-RRB-
cord-256201-vjzfzshh	44	20	,	,	,
cord-256201-vjzfzshh	44	21	yet	yet	CC
cord-256201-vjzfzshh	44	22	no	no	DT
cord-256201-vjzfzshh	44	23	obvious	obvious	JJ
cord-256201-vjzfzshh	44	24	growth	growth	NN
cord-256201-vjzfzshh	44	25	defects	defect	NNS
cord-256201-vjzfzshh	44	26	under	under	IN
cord-256201-vjzfzshh	44	27	standard	standard	JJ
cord-256201-vjzfzshh	44	28	conditions	condition	NNS
cord-256201-vjzfzshh	44	29	.	.	.
cord-256201-vjzfzshh	45	1	However	however	RB
cord-256201-vjzfzshh	45	2	,	,	,
cord-256201-vjzfzshh	45	3	the	the	DT
cord-256201-vjzfzshh	45	4	efficacy	efficacy	NN
cord-256201-vjzfzshh	45	5	of	of	IN
cord-256201-vjzfzshh	45	6	GATC	GATC	NNP
cord-256201-vjzfzshh	45	7	-	-	HYPH
cord-256201-vjzfzshh	45	8	driven	drive	VBN
cord-256201-vjzfzshh	45	9	MMR	MMR	NNP
cord-256201-vjzfzshh	45	10	was	be	VBD
cord-256201-vjzfzshh	45	11	curtailed	curtail	VBN
cord-256201-vjzfzshh	45	12	by	by	IN
cord-256201-vjzfzshh	45	13	poor	poor	JJ
cord-256201-vjzfzshh	45	14	methylation	methylation	NN
cord-256201-vjzfzshh	45	15	of	of	IN
cord-256201-vjzfzshh	45	16	the	the	DT
cord-256201-vjzfzshh	45	17	phage	phage	NN
cord-256201-vjzfzshh	45	18	DNA	dna	NN
cord-256201-vjzfzshh	45	19	,	,	,
cord-256201-vjzfzshh	45	20	preventing	prevent	VBG
cord-256201-vjzfzshh	45	21	recognition	recognition	NN
cord-256201-vjzfzshh	45	22	of	of	IN
cord-256201-vjzfzshh	45	23	the	the	DT
cord-256201-vjzfzshh	45	24	parental	parental	JJ
cord-256201-vjzfzshh	45	25	strand	strand	NN
cord-256201-vjzfzshh	45	26	.	.	.
cord-256201-vjzfzshh	46	1	Furthermore	furthermore	RB
cord-256201-vjzfzshh	46	2	,	,	,
cord-256201-vjzfzshh	46	3	after	after	IN
cord-256201-vjzfzshh	46	4	constructing	construct	VBG
cord-256201-vjzfzshh	46	5	several	several	JJ
cord-256201-vjzfzshh	46	6	mutants	mutant	NNS
cord-256201-vjzfzshh	46	7	in	in	IN
cord-256201-vjzfzshh	46	8	which	which	WDT
cord-256201-vjzfzshh	46	9	the	the	DT
cord-256201-vjzfzshh	46	10	number	number	NN
cord-256201-vjzfzshh	46	11	and	and	CC
cord-256201-vjzfzshh	46	12	location	location	NN
cord-256201-vjzfzshh	46	13	of	of	IN
cord-256201-vjzfzshh	46	14	GATC	GATC	NNP
cord-256201-vjzfzshh	46	15	sites	site	NNS
cord-256201-vjzfzshh	46	16	were	be	VBD
cord-256201-vjzfzshh	46	17	varied	varied	JJ
cord-256201-vjzfzshh	46	18	,	,	,
cord-256201-vjzfzshh	46	19	we	-PRON-	PRP
cord-256201-vjzfzshh	46	20	found	find	VBD
cord-256201-vjzfzshh	46	21	that	that	IN
cord-256201-vjzfzshh	46	22	their	-PRON-	PRP$
cord-256201-vjzfzshh	46	23	effects	effect	NNS
cord-256201-vjzfzshh	46	24	on	on	IN
cord-256201-vjzfzshh	46	25	mutation	mutation	NN
cord-256201-vjzfzshh	46	26	rate	rate	NN
cord-256201-vjzfzshh	46	27	were	be	VBD
cord-256201-vjzfzshh	46	28	non	non	JJ
cord-256201-vjzfzshh	46	29	-	-	JJ
cord-256201-vjzfzshh	46	30	additive	additive	JJ
cord-256201-vjzfzshh	46	31	and	and	CC
cord-256201-vjzfzshh	46	32	highly	highly	RB
cord-256201-vjzfzshh	46	33	variable	variable	JJ
cord-256201-vjzfzshh	46	34	,	,	,
cord-256201-vjzfzshh	46	35	with	with	IN
cord-256201-vjzfzshh	46	36	some	some	DT
cord-256201-vjzfzshh	46	37	combinations	combination	NNS
cord-256201-vjzfzshh	46	38	achieving	achieve	VBG
cord-256201-vjzfzshh	46	39	an	an	DT
cord-256201-vjzfzshh	46	40	up	up	NN
cord-256201-vjzfzshh	46	41	to	to	IN
cord-256201-vjzfzshh	46	42	fiftyfold	fiftyfold	JJ
cord-256201-vjzfzshh	46	43	reduction	reduction	NN
cord-256201-vjzfzshh	46	44	in	in	IN
cord-256201-vjzfzshh	46	45	mutation	mutation	NN
cord-256201-vjzfzshh	46	46	rate	rate	NN
cord-256201-vjzfzshh	46	47	while	while	IN
cord-256201-vjzfzshh	46	48	others	other	NNS
cord-256201-vjzfzshh	46	49	having	have	VBG
cord-256201-vjzfzshh	46	50	no	no	DT
cord-256201-vjzfzshh	46	51	effects	effect	NNS
cord-256201-vjzfzshh	46	52	.	.	.
cord-256201-vjzfzshh	47	1	The	the	DT
cord-256201-vjzfzshh	47	2	highest	high	JJS
cord-256201-vjzfzshh	47	3	efficiencies	efficiency	NNS
cord-256201-vjzfzshh	47	4	were	be	VBD
cord-256201-vjzfzshh	47	5	shown	show	VBN
cord-256201-vjzfzshh	47	6	by	by	IN
cord-256201-vjzfzshh	47	7	some	some	DT
cord-256201-vjzfzshh	47	8	intergenic	intergenic	JJ
cord-256201-vjzfzshh	47	9	GATCs	GATCs	NNPS
cord-256201-vjzfzshh	47	10	,	,	,
cord-256201-vjzfzshh	47	11	suggesting	suggest	VBG
cord-256201-vjzfzshh	47	12	that	that	IN
cord-256201-vjzfzshh	47	13	steric	steric	NN
cord-256201-vjzfzshh	47	14	constrains	constrain	NNS
cord-256201-vjzfzshh	47	15	such	such	JJ
cord-256201-vjzfzshh	47	16	as	as	IN
cord-256201-vjzfzshh	47	17	availability	availability	NN
cord-256201-vjzfzshh	47	18	of	of	IN
cord-256201-vjzfzshh	47	19	the	the	DT
cord-256201-vjzfzshh	47	20	DNA	dna	NN
cord-256201-vjzfzshh	47	21	to	to	IN
cord-256201-vjzfzshh	47	22	MutH	MutH	NNP
cord-256201-vjzfzshh	47	23	may	may	MD
cord-256201-vjzfzshh	47	24	be	be	VB
cord-256201-vjzfzshh	47	25	important	important	JJ
cord-256201-vjzfzshh	47	26	for	for	IN
cord-256201-vjzfzshh	47	27	MMR	MMR	NNP
cord-256201-vjzfzshh	47	28	.	.	.
cord-256201-vjzfzshh	48	1	Finally	finally	RB
cord-256201-vjzfzshh	48	2	,	,	,
cord-256201-vjzfzshh	48	3	we	-PRON-	PRP
cord-256201-vjzfzshh	48	4	found	find	VBD
cord-256201-vjzfzshh	48	5	that	that	IN
cord-256201-vjzfzshh	48	6	the	the	DT
cord-256201-vjzfzshh	48	7	mutation	mutation	NN
cord-256201-vjzfzshh	48	8	rate	rate	NN
cord-256201-vjzfzshh	48	9	reduction	reduction	NN
cord-256201-vjzfzshh	48	10	afforded	afford	VBN
cord-256201-vjzfzshh	48	11	by	by	IN
cord-256201-vjzfzshh	48	12	the	the	DT
cord-256201-vjzfzshh	48	13	twenty	twenty	CD
cord-256201-vjzfzshh	48	14	GATC	GATC	NNP
cord-256201-vjzfzshh	48	15	motifs	motif	NNS
cord-256201-vjzfzshh	48	16	was	be	VBD
cord-256201-vjzfzshh	48	17	fully	fully	RB
cord-256201-vjzfzshh	48	18	reverted	revert	VBN
cord-256201-vjzfzshh	48	19	at	at	IN
cord-256201-vjzfzshh	48	20	42	42	CD
cord-256201-vjzfzshh	48	21	C	C	NNP
cord-256201-vjzfzshh	48	22	and	and	CC
cord-256201-vjzfzshh	48	23	in	in	IN
cord-256201-vjzfzshh	48	24	the	the	DT
cord-256201-vjzfzshh	48	25	presence	presence	NN
cord-256201-vjzfzshh	48	26	of	of	IN
cord-256201-vjzfzshh	48	27	the	the	DT
cord-256201-vjzfzshh	48	28	base	base	NN
cord-256201-vjzfzshh	48	29	analog	analog	NN
cord-256201-vjzfzshh	48	30	5-fluorouracil	5-fluorouracil	CD
cord-256201-vjzfzshh	48	31	(	(	-LRB-
cord-256201-vjzfzshh	48	32	5-FU	5-fu	CD
cord-256201-vjzfzshh	48	33	)	)	-RRB-
cord-256201-vjzfzshh	48	34	,	,	,
cord-256201-vjzfzshh	48	35	two	two	CD
cord-256201-vjzfzshh	48	36	stress	stress	NN
cord-256201-vjzfzshh	48	37	factors	factor	NNS
cord-256201-vjzfzshh	48	38	that	that	WDT
cord-256201-vjzfzshh	48	39	promote	promote	VBP
cord-256201-vjzfzshh	48	40	overexpression	overexpression	NN
cord-256201-vjzfzshh	48	41	of	of	IN
cord-256201-vjzfzshh	48	42	repair	repair	NN
cord-256201-vjzfzshh	48	43	-	-	HYPH
cord-256201-vjzfzshh	48	44	associated	associate	VBN
cord-256201-vjzfzshh	48	45	error	error	NN
cord-256201-vjzfzshh	48	46	prone	prone	JJ
cord-256201-vjzfzshh	48	47	polymerases	polymerase	NNS
cord-256201-vjzfzshh	48	48	(	(	-LRB-
cord-256201-vjzfzshh	48	49	Layton	Layton	NNP
cord-256201-vjzfzshh	48	50	and	and	CC
cord-256201-vjzfzshh	48	51	Foster	Foster	NNP
cord-256201-vjzfzshh	48	52	2005	2005	CD
cord-256201-vjzfzshh	48	53	;	;	:
cord-256201-vjzfzshh	48	54	Malkova	Malkova	NNP
cord-256201-vjzfzshh	48	55	and	and	CC
cord-256201-vjzfzshh	48	56	Haber	Haber	NNP
cord-256201-vjzfzshh	48	57	2012	2012	CD
cord-256201-vjzfzshh	48	58	)	)	-RRB-
cord-256201-vjzfzshh	48	59	,	,	,
cord-256201-vjzfzshh	48	60	thus	thus	RB
cord-256201-vjzfzshh	48	61	suggesting	suggest	VBG
cord-256201-vjzfzshh	48	62	that	that	IN
cord-256201-vjzfzshh	48	63	addition	addition	NN
cord-256201-vjzfzshh	48	64	of	of	IN
cord-256201-vjzfzshh	48	65	GATC	GATC	NNP
cord-256201-vjzfzshh	48	66	motifs	motif	NNS
cord-256201-vjzfzshh	48	67	renders	render	VBZ
cord-256201-vjzfzshh	48	68	the	the	DT
cord-256201-vjzfzshh	48	69	phage	phage	NN
cord-256201-vjzfzshh	48	70	sensitive	sensitive	JJ
cord-256201-vjzfzshh	48	71	to	to	IN
cord-256201-vjzfzshh	48	72	stress	stress	NN
cord-256201-vjzfzshh	48	73	-	-	HYPH
cord-256201-vjzfzshh	48	74	induced	induce	VBN
cord-256201-vjzfzshh	48	75	mutagenesis	mutagenesis	NN
cord-256201-vjzfzshh	48	76	.	.	.
cord-256201-vjzfzshh	49	1	The	the	DT
cord-256201-vjzfzshh	49	2	E.	E.	NNP
cord-256201-vjzfzshh	49	3	coli	coli	NNS
cord-256201-vjzfzshh	49	4	C	c	NN
cord-256201-vjzfzshh	49	5	strain	strain	NN
cord-256201-vjzfzshh	49	6	IJ1862	IJ1862	NNP
cord-256201-vjzfzshh	49	7	was	be	VBD
cord-256201-vjzfzshh	49	8	obtained	obtain	VBN
cord-256201-vjzfzshh	49	9	from	from	IN
cord-256201-vjzfzshh	49	10	Prof.	Prof.	NNP
cord-256201-vjzfzshh	49	11	James	James	NNP
cord-256201-vjzfzshh	49	12	J.	J.	NNP
cord-256201-vjzfzshh	49	13	Bull	Bull	NNP
cord-256201-vjzfzshh	49	14	.	.	.
cord-256201-vjzfzshh	50	1	The	the	DT
cord-256201-vjzfzshh	50	2	gro87	gro87	CD
cord-256201-vjzfzshh	50	3	mutant	mutant	NN
cord-256201-vjzfzshh	50	4	was	be	VBD
cord-256201-vjzfzshh	50	5	provided	provide	VBN
cord-256201-vjzfzshh	50	6	by	by	IN
cord-256201-vjzfzshh	50	7	Prof.	Prof.	NNP
cord-256201-vjzfzshh	50	8	Bentley	Bentley	NNP
cord-256201-vjzfzshh	50	9	A.	a.	NN
cord-256201-vjzfzshh	50	10	Fane	Fane	NNP
cord-256201-vjzfzshh	50	11	(	(	-LRB-
cord-256201-vjzfzshh	50	12	University	University	NNP
cord-256201-vjzfzshh	50	13	of	of	IN
cord-256201-vjzfzshh	50	14	Arizona	Arizona	NNP
cord-256201-vjzfzshh	50	15	)	)	-RRB-
cord-256201-vjzfzshh	50	16	.	.	.
cord-256201-vjzfzshh	51	1	Bacteriophage	bacteriophage	NN
cord-256201-vjzfzshh	51	2	/X174	/X174	.
cord-256201-vjzfzshh	52	1	originally	originally	RB
cord-256201-vjzfzshh	52	2	obtained	obtain	VBN
cord-256201-vjzfzshh	52	3	from	from	IN
cord-256201-vjzfzshh	52	4	Prof.	Prof.	NNP
cord-256201-vjzfzshh	52	5	James	James	NNP
cord-256201-vjzfzshh	52	6	J.	J.	NNP
cord-256201-vjzfzshh	52	7	Bull	Bull	NNP
cord-256201-vjzfzshh	52	8	(	(	-LRB-
cord-256201-vjzfzshh	52	9	Texas	Texas	NNP
cord-256201-vjzfzshh	52	10	University	University	NNP
cord-256201-vjzfzshh	52	11	)	)	-RRB-
cord-256201-vjzfzshh	52	12	was	be	VBD
cord-256201-vjzfzshh	52	13	adapted	adapt	VBN
cord-256201-vjzfzshh	52	14	to	to	IN
cord-256201-vjzfzshh	52	15	our	-PRON-	PRP$
cord-256201-vjzfzshh	52	16	laboratory	laboratory	NN
cord-256201-vjzfzshh	52	17	conditions	condition	NNS
cord-256201-vjzfzshh	52	18	by	by	IN
cord-256201-vjzfzshh	52	19	long	long	JJ
cord-256201-vjzfzshh	52	20	-	-	HYPH
cord-256201-vjzfzshh	52	21	term	term	NN
cord-256201-vjzfzshh	52	22	passaging	passaging	NN
cord-256201-vjzfzshh	52	23	in	in	IN
cord-256201-vjzfzshh	52	24	IJ1862	ij1862	NN
cord-256201-vjzfzshh	52	25	cells	cell	NNS
cord-256201-vjzfzshh	52	26	(	(	-LRB-
cord-256201-vjzfzshh	52	27	Domingo	Domingo	NNP
cord-256201-vjzfzshh	52	28	-	-	HYPH
cord-256201-vjzfzshh	52	29	Calap	Calap	NNP
cord-256201-vjzfzshh	52	30	,	,	,
cord-256201-vjzfzshh	52	31	Cuevas	Cuevas	NNP
cord-256201-vjzfzshh	52	32	,	,	,
cord-256201-vjzfzshh	52	33	and	and	CC
cord-256201-vjzfzshh	52	34	Sanjuá	Sanjuá	NNP
cord-256201-vjzfzshh	52	35	n	n	NNP
cord-256201-vjzfzshh	52	36	2009	2009	CD
cord-256201-vjzfzshh	52	37	)	)	-RRB-
cord-256201-vjzfzshh	52	38	.	.	.
cord-256201-vjzfzshh	53	1	GATC	GATC	NNP
cord-256201-vjzfzshh	53	2	sites	site	NNS
cord-256201-vjzfzshh	53	3	were	be	VBD
cord-256201-vjzfzshh	53	4	engineered	engineer	VBN
cord-256201-vjzfzshh	53	5	in	in	IN
cord-256201-vjzfzshh	53	6	the	the	DT
cord-256201-vjzfzshh	53	7	genetic	genetic	JJ
cord-256201-vjzfzshh	53	8	background	background	NN
cord-256201-vjzfzshh	53	9	of	of	IN
cord-256201-vjzfzshh	53	10	this	this	DT
cord-256201-vjzfzshh	53	11	adapted	adapt	VBN
cord-256201-vjzfzshh	53	12	virus	virus	NN
cord-256201-vjzfzshh	53	13	,	,	,
cord-256201-vjzfzshh	53	14	here	here	RB
cord-256201-vjzfzshh	53	15	denoted	denote	VBD
cord-256201-vjzfzshh	53	16	the	the	DT
cord-256201-vjzfzshh	53	17	WT	WT	NNP
cord-256201-vjzfzshh	53	18	,	,	,
cord-256201-vjzfzshh	53	19	which	which	WDT
cord-256201-vjzfzshh	53	20	contains	contain	VBZ
cord-256201-vjzfzshh	53	21	no	no	DT
cord-256201-vjzfzshh	53	22	GATCs	GATCs	NNPS
cord-256201-vjzfzshh	53	23	(	(	-LRB-
cord-256201-vjzfzshh	53	24	GenBank	GenBank	NNP
cord-256201-vjzfzshh	53	25	accession	accession	NN
cord-256201-vjzfzshh	53	26	GQ153915	gq153915	NN
cord-256201-vjzfzshh	53	27	)	)	-RRB-
cord-256201-vjzfzshh	53	28	.	.	.
cord-256201-vjzfzshh	54	1	The	the	DT
cord-256201-vjzfzshh	54	2	/X174	/X174	NFP
cord-256201-vjzfzshh	54	3	dsDNA	dsdna	RB
cord-256201-vjzfzshh	54	4	replicative	replicative	JJ
cord-256201-vjzfzshh	54	5	form	form	NN
cord-256201-vjzfzshh	54	6	was	be	VBD
cord-256201-vjzfzshh	54	7	purified	purify	VBN
cord-256201-vjzfzshh	54	8	from	from	IN
cord-256201-vjzfzshh	54	9	infected	infected	JJ
cord-256201-vjzfzshh	54	10	cultures	culture	NNS
cord-256201-vjzfzshh	54	11	before	before	IN
cord-256201-vjzfzshh	54	12	lysis	lysis	NN
cord-256201-vjzfzshh	54	13	using	use	VBG
cord-256201-vjzfzshh	54	14	a	a	DT
cord-256201-vjzfzshh	54	15	standard	standard	JJ
cord-256201-vjzfzshh	54	16	miniprep	miniprep	JJ
cord-256201-vjzfzshh	54	17	kit	kit	NN
cord-256201-vjzfzshh	54	18	(	(	-LRB-
cord-256201-vjzfzshh	54	19	Macherey	Macherey	NNP
cord-256201-vjzfzshh	54	20	-	-	HYPH
cord-256201-vjzfzshh	54	21	Nagel	Nagel	NNP
cord-256201-vjzfzshh	54	22	)	)	-RRB-
cord-256201-vjzfzshh	54	23	,	,	,
cord-256201-vjzfzshh	54	24	and	and	CC
cord-256201-vjzfzshh	54	25	500	500	CD
cord-256201-vjzfzshh	54	26	pg	pg	NN
cord-256201-vjzfzshh	54	27	of	of	IN
cord-256201-vjzfzshh	54	28	this	this	DT
cord-256201-vjzfzshh	54	29	DNA	DNA	NNP
cord-256201-vjzfzshh	54	30	were	be	VBD
cord-256201-vjzfzshh	54	31	used	use	VBN
cord-256201-vjzfzshh	54	32	as	as	IN
cord-256201-vjzfzshh	54	33	template	template	NN
cord-256201-vjzfzshh	54	34	for	for	IN
cord-256201-vjzfzshh	54	35	polymerase	polymerase	NN
cord-256201-vjzfzshh	54	36	chain	chain	NN
cord-256201-vjzfzshh	54	37	reaction	reaction	NN
cord-256201-vjzfzshh	54	38	-	-	HYPH
cord-256201-vjzfzshh	54	39	based	base	VBN
cord-256201-vjzfzshh	54	40	mutagenesis	mutagenesis	NN
cord-256201-vjzfzshh	54	41	using	use	VBG
cord-256201-vjzfzshh	54	42	Phusion	Phusion	NNP
cord-256201-vjzfzshh	54	43	high	high	JJ
cord-256201-vjzfzshh	54	44	-	-	HYPH
cord-256201-vjzfzshh	54	45	fidelity	fidelity	NN
cord-256201-vjzfzshh	54	46	DNA	dna	NN
cord-256201-vjzfzshh	54	47	polymerase	polymerase	NN
cord-256201-vjzfzshh	54	48	(	(	-LRB-
cord-256201-vjzfzshh	54	49	Thermo	Thermo	NNP
cord-256201-vjzfzshh	54	50	Scientific	Scientific	NNP
cord-256201-vjzfzshh	54	51	)	)	-RRB-
cord-256201-vjzfzshh	54	52	and	and	CC
cord-256201-vjzfzshh	54	53	contiguous	contiguous	JJ
cord-256201-vjzfzshh	54	54	,	,	,
cord-256201-vjzfzshh	54	55	divergent	divergent	JJ
cord-256201-vjzfzshh	54	56	,	,	,
cord-256201-vjzfzshh	54	57	5'-phosphorylated	5'-phosphorylated	CD
cord-256201-vjzfzshh	54	58	primers	primer	NNS
cord-256201-vjzfzshh	54	59	,	,	,
cord-256201-vjzfzshh	54	60	of	of	IN
cord-256201-vjzfzshh	54	61	which	which	WDT
cord-256201-vjzfzshh	54	62	the	the	DT
cord-256201-vjzfzshh	54	63	reverse	reverse	JJ
cord-256201-vjzfzshh	54	64	primer	primer	NN
cord-256201-vjzfzshh	54	65	carried	carry	VBD
cord-256201-vjzfzshh	54	66	the	the	DT
cord-256201-vjzfzshh	54	67	desired	desire	VBN
cord-256201-vjzfzshh	54	68	nucleotide	nucleotide	JJ
cord-256201-vjzfzshh	54	69	substitution	substitution	NN
cord-256201-vjzfzshh	54	70	.	.	.
cord-256201-vjzfzshh	55	1	Polymerase	polymerase	NN
cord-256201-vjzfzshh	55	2	chain	chain	NN
cord-256201-vjzfzshh	55	3	reaction	reaction	NN
cord-256201-vjzfzshh	55	4	products	product	NNS
cord-256201-vjzfzshh	55	5	were	be	VBD
cord-256201-vjzfzshh	55	6	circularized	circularize	VBN
cord-256201-vjzfzshh	55	7	with	with	IN
cord-256201-vjzfzshh	55	8	the	the	DT
cord-256201-vjzfzshh	55	9	Rapid	Rapid	NNP
cord-256201-vjzfzshh	55	10	DNA	DNA	NNP
cord-256201-vjzfzshh	55	11	ligation	ligation	NN
cord-256201-vjzfzshh	55	12	kit	kit	NN
cord-256201-vjzfzshh	55	13	(	(	-LRB-
cord-256201-vjzfzshh	55	14	Thermo	Thermo	NNP
cord-256201-vjzfzshh	55	15	Scientific	Scientific	NNP
cord-256201-vjzfzshh	55	16	)	)	-RRB-
cord-256201-vjzfzshh	55	17	and	and	CC
cord-256201-vjzfzshh	55	18	used	use	VBN
cord-256201-vjzfzshh	55	19	for	for	IN
cord-256201-vjzfzshh	55	20	transfecting	transfecte	VBG
cord-256201-vjzfzshh	55	21	competent	competent	JJ
cord-256201-vjzfzshh	55	22	IJ1862cells	IJ1862cells	NNPS
cord-256201-vjzfzshh	55	23	by	by	IN
cord-256201-vjzfzshh	55	24	the	the	DT
cord-256201-vjzfzshh	55	25	classical	classical	JJ
cord-256201-vjzfzshh	55	26	heat	heat	NN
cord-256201-vjzfzshh	55	27	-	-	HYPH
cord-256201-vjzfzshh	55	28	shock	shock	NN
cord-256201-vjzfzshh	55	29	method	method	NN
cord-256201-vjzfzshh	55	30	.	.	.
cord-256201-vjzfzshh	56	1	A	a	DT
cord-256201-vjzfzshh	56	2	single	single	JJ
cord-256201-vjzfzshh	56	3	plaque	plaque	NN
cord-256201-vjzfzshh	56	4	was	be	VBD
cord-256201-vjzfzshh	56	5	picked	pick	VBN
cord-256201-vjzfzshh	56	6	,	,	,
cord-256201-vjzfzshh	56	7	resuspended	resuspended	JJ
cord-256201-vjzfzshh	56	8	Lysogeny	Lysogeny	NNP
cord-256201-vjzfzshh	56	9	Broth	Broth	NNP
cord-256201-vjzfzshh	56	10	medium	medium	NN
cord-256201-vjzfzshh	56	11	,	,	,
cord-256201-vjzfzshh	56	12	and	and	CC
cord-256201-vjzfzshh	56	13	stored	store	VBN
cord-256201-vjzfzshh	56	14	at	at	IN
cord-256201-vjzfzshh	56	15	-70	-70	NN
cord-256201-vjzfzshh	56	16	C.	c.	NN
cord-256201-vjzfzshh	57	1	The	the	DT
cord-256201-vjzfzshh	57	2	presence	presence	NN
cord-256201-vjzfzshh	57	3	of	of	IN
cord-256201-vjzfzshh	57	4	each	each	DT
cord-256201-vjzfzshh	57	5	substitution	substitution	NN
cord-256201-vjzfzshh	57	6	was	be	VBD
cord-256201-vjzfzshh	57	7	confirmed	confirm	VBN
cord-256201-vjzfzshh	57	8	by	by	IN
cord-256201-vjzfzshh	57	9	Sanger	Sanger	NNP
cord-256201-vjzfzshh	57	10	sequencing	sequencing	NN
cord-256201-vjzfzshh	57	11	.	.	.
cord-256201-vjzfzshh	58	1	This	this	DT
cord-256201-vjzfzshh	58	2	process	process	NN
cord-256201-vjzfzshh	58	3	was	be	VBD
cord-256201-vjzfzshh	58	4	iterated	iterate	VBN
cord-256201-vjzfzshh	58	5	until	until	IN
cord-256201-vjzfzshh	58	6	twenty	twenty	CD
cord-256201-vjzfzshh	58	7	GATC	GATC	NNP
cord-256201-vjzfzshh	58	8	sites	site	NNS
cord-256201-vjzfzshh	58	9	were	be	VBD
cord-256201-vjzfzshh	58	10	introduced	introduce	VBN
cord-256201-vjzfzshh	58	11	.	.	.
cord-256201-vjzfzshh	59	1	Full	full	JJ
cord-256201-vjzfzshh	59	2	-	-	HYPH
cord-256201-vjzfzshh	59	3	length	length	NN
cord-256201-vjzfzshh	59	4	sequencing	sequencing	NN
cord-256201-vjzfzshh	59	5	of	of	IN
cord-256201-vjzfzshh	59	6	the	the	DT
cord-256201-vjzfzshh	59	7	20GATC	20gatc	CD
cord-256201-vjzfzshh	59	8	virus	virus	NN
cord-256201-vjzfzshh	59	9	was	be	VBD
cord-256201-vjzfzshh	59	10	performed	perform	VBN
cord-256201-vjzfzshh	59	11	to	to	TO
cord-256201-vjzfzshh	59	12	verify	verify	VB
cord-256201-vjzfzshh	59	13	that	that	IN
cord-256201-vjzfzshh	59	14	all	all	DT
cord-256201-vjzfzshh	59	15	mutations	mutation	NNS
cord-256201-vjzfzshh	59	16	were	be	VBD
cord-256201-vjzfzshh	59	17	present	present	JJ
cord-256201-vjzfzshh	59	18	and	and	CC
cord-256201-vjzfzshh	59	19	that	that	IN
cord-256201-vjzfzshh	59	20	no	no	DT
cord-256201-vjzfzshh	59	21	other	other	JJ
cord-256201-vjzfzshh	59	22	changes	change	NNS
cord-256201-vjzfzshh	59	23	were	be	VBD
cord-256201-vjzfzshh	59	24	introduced	introduce	VBN
cord-256201-vjzfzshh	59	25	.	.	.
cord-256201-vjzfzshh	60	1	Each	each	DT
cord-256201-vjzfzshh	60	2	test	test	NN
cord-256201-vjzfzshh	60	3	consisted	consist	VBD
cord-256201-vjzfzshh	60	4	of	of	IN
cord-256201-vjzfzshh	60	5	twenty	twenty	CD
cord-256201-vjzfzshh	60	6	-	-	HYPH
cord-256201-vjzfzshh	60	7	four	four	CD
cord-256201-vjzfzshh	60	8	independent	independent	JJ
cord-256201-vjzfzshh	60	9	0.5	0.5	CD
cord-256201-vjzfzshh	60	10	ml	ml	NN
cord-256201-vjzfzshh	60	11	IJ1862	ij1862	NN
cord-256201-vjzfzshh	60	12	cultures	culture	NNS
cord-256201-vjzfzshh	60	13	inoculated	inoculate	VBN
cord-256201-vjzfzshh	60	14	with	with	IN
cord-256201-vjzfzshh	60	15	the	the	DT
cord-256201-vjzfzshh	60	16	indicated	indicate	VBN
cord-256201-vjzfzshh	60	17	initial	initial	JJ
cord-256201-vjzfzshh	60	18	number	number	NN
cord-256201-vjzfzshh	60	19	(	(	-LRB-
cord-256201-vjzfzshh	60	20	N	n	CD
cord-256201-vjzfzshh	60	21	0	0	CD
cord-256201-vjzfzshh	60	22	)	)	-RRB-
cord-256201-vjzfzshh	60	23	of	of	IN
cord-256201-vjzfzshh	60	24	plaque	plaque	NN
cord-256201-vjzfzshh	60	25	forming	form	VBG
cord-256201-vjzfzshh	60	26	units	unit	NNS
cord-256201-vjzfzshh	60	27	(	(	-LRB-
cord-256201-vjzfzshh	60	28	pfu	pfu	NN
cord-256201-vjzfzshh	60	29	)	)	-RRB-
cord-256201-vjzfzshh	60	30	and	and	CC
cord-256201-vjzfzshh	60	31	incubated	incubate	VBN
cord-256201-vjzfzshh	60	32	in	in	IN
cord-256201-vjzfzshh	60	33	a	a	DT
cord-256201-vjzfzshh	60	34	Thermomix	Thermomix	NNP
cord-256201-vjzfzshh	60	35	shaker	shaker	NN
cord-256201-vjzfzshh	60	36	(	(	-LRB-
cord-256201-vjzfzshh	60	37	Eppendorf	Eppendorf	NNP
cord-256201-vjzfzshh	60	38	)	)	-RRB-
cord-256201-vjzfzshh	60	39	at	at	IN
cord-256201-vjzfzshh	60	40	650	650	CD
cord-256201-vjzfzshh	60	41	rpm	rpm	NN
cord-256201-vjzfzshh	60	42	until	until	IN
cord-256201-vjzfzshh	60	43	N	n	NN
cord-256201-vjzfzshh	60	44	1	1	CD
cord-256201-vjzfzshh	60	45	pfu	pfu	NN
cord-256201-vjzfzshh	60	46	were	be	VBD
cord-256201-vjzfzshh	60	47	produced	produce	VBN
cord-256201-vjzfzshh	60	48	.	.	.
cord-256201-vjzfzshh	61	1	This	this	DT
cord-256201-vjzfzshh	61	2	growth	growth	NN
cord-256201-vjzfzshh	61	3	phase	phase	NN
cord-256201-vjzfzshh	61	4	was	be	VBD
cord-256201-vjzfzshh	61	5	done	do	VBN
cord-256201-vjzfzshh	61	6	under	under	IN
cord-256201-vjzfzshh	61	7	standard	standard	JJ
cord-256201-vjzfzshh	61	8	conditions	condition	NNS
cord-256201-vjzfzshh	61	9	(	(	-LRB-
cord-256201-vjzfzshh	61	10	37	37	CD
cord-256201-vjzfzshh	61	11	C	C	NNP
cord-256201-vjzfzshh	61	12	)	)	-RRB-
cord-256201-vjzfzshh	61	13	,	,	,
cord-256201-vjzfzshh	61	14	at	at	IN
cord-256201-vjzfzshh	61	15	high	high	JJ
cord-256201-vjzfzshh	61	16	temperature	temperature	NN
cord-256201-vjzfzshh	61	17	(	(	-LRB-
cord-256201-vjzfzshh	61	18	42	42	CD
cord-256201-vjzfzshh	61	19	C	C	NNP
cord-256201-vjzfzshh	61	20	)	)	-RRB-
cord-256201-vjzfzshh	61	21	,	,	,
cord-256201-vjzfzshh	61	22	or	or	CC
cord-256201-vjzfzshh	61	23	in	in	IN
cord-256201-vjzfzshh	61	24	the	the	DT
cord-256201-vjzfzshh	61	25	presence	presence	NN
cord-256201-vjzfzshh	61	26	of	of	IN
cord-256201-vjzfzshh	61	27	10	10	CD
cord-256201-vjzfzshh	61	28	ng	ng	NN
cord-256201-vjzfzshh	61	29	/	/	SYM
cord-256201-vjzfzshh	61	30	ml	ml	NN
cord-256201-vjzfzshh	61	31	5-FU	5-fu	CD
cord-256201-vjzfzshh	61	32	(	(	-LRB-
cord-256201-vjzfzshh	61	33	37	37	CD
cord-256201-vjzfzshh	61	34	C	c	NN
cord-256201-vjzfzshh	61	35	)	)	-RRB-
cord-256201-vjzfzshh	61	36	by	by	IN
cord-256201-vjzfzshh	61	37	preincubating	preincubate	VBG
cord-256201-vjzfzshh	61	38	cells	cell	NNS
cord-256201-vjzfzshh	61	39	with	with	IN
cord-256201-vjzfzshh	61	40	5-FU	5-fu	CD
cord-256201-vjzfzshh	61	41	10	10	CD
cord-256201-vjzfzshh	61	42	min	min	NN
cord-256201-vjzfzshh	61	43	before	before	IN
cord-256201-vjzfzshh	61	44	infection	infection	NN
cord-256201-vjzfzshh	61	45	.	.	.
cord-256201-vjzfzshh	62	1	All	all	DT
cord-256201-vjzfzshh	62	2	titrations	titration	NNS
cord-256201-vjzfzshh	62	3	were	be	VBD
cord-256201-vjzfzshh	62	4	done	do	VBN
cord-256201-vjzfzshh	62	5	under	under	IN
cord-256201-vjzfzshh	62	6	the	the	DT
cord-256201-vjzfzshh	62	7	same	same	JJ
cord-256201-vjzfzshh	62	8	,	,	,
cord-256201-vjzfzshh	62	9	standard	standard	JJ
cord-256201-vjzfzshh	62	10	conditions	condition	NNS
cord-256201-vjzfzshh	62	11	(	(	-LRB-
cord-256201-vjzfzshh	62	12	IJ1862	ij1862	NN
cord-256201-vjzfzshh	62	13	cells	cell	NNS
cord-256201-vjzfzshh	62	14	with	with	IN
cord-256201-vjzfzshh	62	15	agar	agar	NN
cord-256201-vjzfzshh	62	16	overlay	overlay	NN
cord-256201-vjzfzshh	62	17	,	,	,
cord-256201-vjzfzshh	62	18	37	37	CD
cord-256201-vjzfzshh	62	19	C	c	NN
cord-256201-vjzfzshh	62	20	,	,	,
cord-256201-vjzfzshh	62	21	no	no	DT
cord-256201-vjzfzshh	62	22	5-FU	5-fu	CD
cord-256201-vjzfzshh	62	23	)	)	-RRB-
cord-256201-vjzfzshh	62	24	.	.	.
cord-256201-vjzfzshh	63	1	N	n	NN
cord-256201-vjzfzshh	63	2	1	1	CD
cord-256201-vjzfzshh	63	3	was	be	VBD
cord-256201-vjzfzshh	63	4	determined	determine	VBN
cord-256201-vjzfzshh	63	5	by	by	IN
cord-256201-vjzfzshh	63	6	titrating	titrate	VBG
cord-256201-vjzfzshh	63	7	six	six	CD
cord-256201-vjzfzshh	63	8	of	of	IN
cord-256201-vjzfzshh	63	9	twenty	twenty	CD
cord-256201-vjzfzshh	63	10	-	-	HYPH
cord-256201-vjzfzshh	63	11	four	four	CD
cord-256201-vjzfzshh	63	12	random	random	JJ
cord-256201-vjzfzshh	63	13	cultures	culture	NNS
cord-256201-vjzfzshh	63	14	.	.	.
cord-256201-vjzfzshh	64	1	To	to	TO
cord-256201-vjzfzshh	64	2	score	score	VB
cord-256201-vjzfzshh	64	3	mutants	mutant	NNS
cord-256201-vjzfzshh	64	4	,	,	,
cord-256201-vjzfzshh	64	5	0.4	0.4	CD
cord-256201-vjzfzshh	64	6	ml	ml	XX
cord-256201-vjzfzshh	64	7	(	(	-LRB-
cord-256201-vjzfzshh	64	8	80	80	CD
cord-256201-vjzfzshh	64	9	%	%	NN
cord-256201-vjzfzshh	64	10	of	of	IN
cord-256201-vjzfzshh	64	11	the	the	DT
cord-256201-vjzfzshh	64	12	total	total	JJ
cord-256201-vjzfzshh	64	13	volume	volume	NN
cord-256201-vjzfzshh	64	14	)	)	-RRB-
cord-256201-vjzfzshh	64	15	was	be	VBD
cord-256201-vjzfzshh	64	16	titrated	titrate	VBN
cord-256201-vjzfzshh	64	17	on	on	IN
cord-256201-vjzfzshh	64	18	the	the	DT
cord-256201-vjzfzshh	64	19	restrictive	restrictive	JJ
cord-256201-vjzfzshh	64	20	E.	E.	NNP
cord-256201-vjzfzshh	64	21	coli	coli	NNS
cord-256201-vjzfzshh	64	22	gro87	gro87	CD
cord-256201-vjzfzshh	64	23	strain	strain	NN
cord-256201-vjzfzshh	64	24	,	,	,
cord-256201-vjzfzshh	64	25	a	a	DT
cord-256201-vjzfzshh	64	26	rep	rep	NN
cord-256201-vjzfzshh	64	27	mutant	mutant	NN
cord-256201-vjzfzshh	64	28	where	where	WRB
cord-256201-vjzfzshh	64	29	only	only	RB
cord-256201-vjzfzshh	64	30	/X174	/X174	NFP
cord-256201-vjzfzshh	64	31	mutants	mutant	NNS
cord-256201-vjzfzshh	64	32	with	with	IN
cord-256201-vjzfzshh	64	33	certain	certain	JJ
cord-256201-vjzfzshh	64	34	mutations	mutation	NNS
cord-256201-vjzfzshh	64	35	in	in	IN
cord-256201-vjzfzshh	64	36	the	the	DT
cord-256201-vjzfzshh	64	37	N	n	CD
cord-256201-vjzfzshh	64	38	-	-	HYPH
cord-256201-vjzfzshh	64	39	terminal	terminal	JJ
cord-256201-vjzfzshh	64	40	end	end	NN
cord-256201-vjzfzshh	64	41	of	of	IN
cord-256201-vjzfzshh	64	42	the	the	DT
cord-256201-vjzfzshh	64	43	viral	viral	JJ
cord-256201-vjzfzshh	64	44	protein	protein	NN
cord-256201-vjzfzshh	65	1	A	a	DT
cord-256201-vjzfzshh	65	2	can	can	MD
cord-256201-vjzfzshh	65	3	form	form	VB
cord-256201-vjzfzshh	65	4	plaques	plaque	NNS
cord-256201-vjzfzshh	65	5	(	(	-LRB-
cord-256201-vjzfzshh	65	6	Ekechukwu	Ekechukwu	NNP
cord-256201-vjzfzshh	65	7	,	,	,
cord-256201-vjzfzshh	65	8	Oberste	Oberste	NNP
cord-256201-vjzfzshh	65	9	,	,	,
cord-256201-vjzfzshh	65	10	and	and	CC
cord-256201-vjzfzshh	65	11	Fane	Fane	NNP
cord-256201-vjzfzshh	65	12	1995	1995	CD
cord-256201-vjzfzshh	65	13	)	)	-RRB-
cord-256201-vjzfzshh	65	14	,	,	,
cord-256201-vjzfzshh	65	15	the	the	DT
cord-256201-vjzfzshh	65	16	total	total	JJ
cord-256201-vjzfzshh	65	17	number	number	NN
cord-256201-vjzfzshh	65	18	of	of	IN
cord-256201-vjzfzshh	65	19	different	different	JJ
cord-256201-vjzfzshh	65	20	substitutions	substitution	NNS
cord-256201-vjzfzshh	65	21	leading	lead	VBG
cord-256201-vjzfzshh	65	22	to	to	IN
cord-256201-vjzfzshh	65	23	the	the	DT
cord-256201-vjzfzshh	65	24	resistance	resistance	NN
cord-256201-vjzfzshh	65	25	phenotype	phenotype	NN
cord-256201-vjzfzshh	65	26	being	be	VBG
cord-256201-vjzfzshh	65	27	T	T	NNP
cord-256201-vjzfzshh	65	28	¼	¼	NNP
cord-256201-vjzfzshh	65	29	7	7	CD
cord-256201-vjzfzshh	65	30	under	under	IN
cord-256201-vjzfzshh	65	31	our	-PRON-	PRP$
cord-256201-vjzfzshh	65	32	assay	assay	NN
cord-256201-vjzfzshh	65	33	conditions	condition	NNS
cord-256201-vjzfzshh	65	34	(	(	-LRB-
cord-256201-vjzfzshh	65	35	Cuevas	Cuevas	NNP
cord-256201-vjzfzshh	65	36	,	,	,
cord-256201-vjzfzshh	65	37	Duffy	Duffy	NNP
cord-256201-vjzfzshh	65	38	,	,	,
cord-256201-vjzfzshh	65	39	and	and	CC
cord-256201-vjzfzshh	65	40	Sanjuá	Sanjuá	NNP
cord-256201-vjzfzshh	65	41	n	n	NNP
cord-256201-vjzfzshh	65	42	2009	2009	CD
cord-256201-vjzfzshh	65	43	)	)	-RRB-
cord-256201-vjzfzshh	65	44	.	.	.
cord-256201-vjzfzshh	66	1	We	-PRON-	PRP
cord-256201-vjzfzshh	66	2	estimated	estimate	VBD
cord-256201-vjzfzshh	66	3	the	the	DT
cord-256201-vjzfzshh	66	4	rate	rate	NN
cord-256201-vjzfzshh	66	5	m	m	NN
cord-256201-vjzfzshh	66	6	at	at	IN
cord-256201-vjzfzshh	66	7	which	which	WDT
cord-256201-vjzfzshh	66	8	gro87-resistant	gro87-resistant	JJ
cord-256201-vjzfzshh	66	9	mutants	mutant	NNS
cord-256201-vjzfzshh	66	10	appeared	appear	VBD
cord-256201-vjzfzshh	66	11	using	use	VBG
cord-256201-vjzfzshh	66	12	the	the	DT
cord-256201-vjzfzshh	66	13	null	null	JJ
cord-256201-vjzfzshh	66	14	-	-	HYPH
cord-256201-vjzfzshh	66	15	class	class	NN
cord-256201-vjzfzshh	66	16	method	method	NN
cord-256201-vjzfzshh	66	17	,	,	,
cord-256201-vjzfzshh	66	18	which	which	WDT
cord-256201-vjzfzshh	66	19	is	be	VBZ
cord-256201-vjzfzshh	66	20	based	base	VBN
cord-256201-vjzfzshh	66	21	on	on	IN
cord-256201-vjzfzshh	66	22	counting	count	VBG
cord-256201-vjzfzshh	66	23	the	the	DT
cord-256201-vjzfzshh	66	24	proportion	proportion	NN
cord-256201-vjzfzshh	66	25	of	of	IN
cord-256201-vjzfzshh	66	26	cultures	culture	NNS
cord-256201-vjzfzshh	66	27	showing	show	VBG
cord-256201-vjzfzshh	66	28	zero	zero	CD
cord-256201-vjzfzshh	66	29	versus	versus	NN
cord-256201-vjzfzshh	66	30	at	at	RB
cord-256201-vjzfzshh	66	31	least	least	RBS
cord-256201-vjzfzshh	66	32	one	one	CD
cord-256201-vjzfzshh	66	33	mutant	mutant	NN
cord-256201-vjzfzshh	66	34	.	.	.
cord-256201-vjzfzshh	67	1	The	the	DT
cord-256201-vjzfzshh	67	2	number	number	NN
cord-256201-vjzfzshh	67	3	of	of	IN
cord-256201-vjzfzshh	67	4	mutations	mutation	NNS
cord-256201-vjzfzshh	67	5	per	per	IN
cord-256201-vjzfzshh	67	6	culture	culture	NN
cord-256201-vjzfzshh	67	7	should	should	MD
cord-256201-vjzfzshh	67	8	follow	follow	VB
cord-256201-vjzfzshh	67	9	a	a	DT
cord-256201-vjzfzshh	67	10	Poisson	Poisson	NNP
cord-256201-vjzfzshh	67	11	distribution	distribution	NN
cord-256201-vjzfzshh	67	12	with	with	IN
cord-256201-vjzfzshh	67	13	parameter	parameter	NN
cord-256201-vjzfzshh	67	14	k	k	NNP
cord-256201-vjzfzshh	67	15	¼	¼	NNP
cord-256201-vjzfzshh	67	16	m(N	m(N	NNP
cord-256201-vjzfzshh	67	17	1	1	CD
cord-256201-vjzfzshh	67	18	-N	-n	SYM
cord-256201-vjzfzshh	67	19	0	0	CD
cord-256201-vjzfzshh	67	20	)	)	-RRB-
cord-256201-vjzfzshh	67	21	,	,	,
cord-256201-vjzfzshh	67	22	such	such	JJ
cord-256201-vjzfzshh	67	23	that	that	IN
cord-256201-vjzfzshh	67	24	the	the	DT
cord-256201-vjzfzshh	67	25	expected	expect	VBN
cord-256201-vjzfzshh	67	26	probability	probability	NN
cord-256201-vjzfzshh	67	27	of	of	IN
cord-256201-vjzfzshh	67	28	no	no	DT
cord-256201-vjzfzshh	67	29	mutants	mutant	NNS
cord-256201-vjzfzshh	67	30	in	in	IN
cord-256201-vjzfzshh	67	31	a	a	DT
cord-256201-vjzfzshh	67	32	culture	culture	NN
cord-256201-vjzfzshh	67	33	is	be	VBZ
cord-256201-vjzfzshh	67	34	P	p	NN
cord-256201-vjzfzshh	67	35	0	0	CD
cord-256201-vjzfzshh	67	36	¼	¼	CD
cord-256201-vjzfzshh	67	37	exp[-m(N	exp[-m(N	NNP
cord-256201-vjzfzshh	67	38	1	1	CD
cord-256201-vjzfzshh	67	39	-N	-n	SYM
cord-256201-vjzfzshh	67	40	0	0	NFP
cord-256201-vjzfzshh	67	41	)	)	-RRB-
cord-256201-vjzfzshh	67	42	]	]	-RRB-
cord-256201-vjzfzshh	67	43	.	.	.
cord-256201-vjzfzshh	68	1	Mutation	mutation	NN
cord-256201-vjzfzshh	68	2	rates	rate	NNS
cord-256201-vjzfzshh	68	3	per	per	IN
cord-256201-vjzfzshh	68	4	nucleotide	nucleotide	JJ
cord-256201-vjzfzshh	68	5	per	per	IN
cord-256201-vjzfzshh	68	6	round	round	NN
cord-256201-vjzfzshh	68	7	of	of	IN
cord-256201-vjzfzshh	68	8	copying	copying	NN
cord-256201-vjzfzshh	68	9	(	(	-LRB-
cord-256201-vjzfzshh	68	10	m	m	NNP
cord-256201-vjzfzshh	68	11	/	/	SYM
cord-256201-vjzfzshh	68	12	n	n	NN
cord-256201-vjzfzshh	68	13	/	/	SYM
cord-256201-vjzfzshh	68	14	r	r	NN
cord-256201-vjzfzshh	68	15	)	)	-RRB-
cord-256201-vjzfzshh	68	16	were	be	VBD
cord-256201-vjzfzshh	68	17	then	then	RB
cord-256201-vjzfzshh	68	18	calculated	calculate	VBN
cord-256201-vjzfzshh	68	19	as	as	IN
cord-256201-vjzfzshh	68	20	m	m	NNP
cord-256201-vjzfzshh	68	21	¼	¼	NNP
cord-256201-vjzfzshh	68	22	3	3	CD
cord-256201-vjzfzshh	68	23	m	m	NNP
cord-256201-vjzfzshh	68	24	/	/	SYM
cord-256201-vjzfzshh	68	25	T	T	NNP
cord-256201-vjzfzshh	68	26	,	,	,
cord-256201-vjzfzshh	68	27	where	where	WRB
cord-256201-vjzfzshh	68	28	the	the	DT
cord-256201-vjzfzshh	68	29	factor	factor	NN
cord-256201-vjzfzshh	68	30	3	3	CD
cord-256201-vjzfzshh	68	31	stands	stand	VBZ
cord-256201-vjzfzshh	68	32	for	for	IN
cord-256201-vjzfzshh	68	33	the	the	DT
cord-256201-vjzfzshh	68	34	fact	fact	NN
cord-256201-vjzfzshh	68	35	that	that	IN
cord-256201-vjzfzshh	68	36	each	each	DT
cord-256201-vjzfzshh	68	37	base	base	NN
cord-256201-vjzfzshh	68	38	can	can	MD
cord-256201-vjzfzshh	68	39	mutate	mutate	VB
cord-256201-vjzfzshh	68	40	to	to	IN
cord-256201-vjzfzshh	68	41	three	three	CD
cord-256201-vjzfzshh	68	42	different	different	JJ
cord-256201-vjzfzshh	68	43	bases	basis	NNS
cord-256201-vjzfzshh	68	44	.	.	.
cord-256201-vjzfzshh	69	1	Three	three	CD
cord-256201-vjzfzshh	69	2	independent	independent	JJ
cord-256201-vjzfzshh	69	3	tests	test	NNS
cord-256201-vjzfzshh	69	4	were	be	VBD
cord-256201-vjzfzshh	69	5	performed	perform	VBN
cord-256201-vjzfzshh	69	6	for	for	IN
cord-256201-vjzfzshh	69	7	each	each	DT
cord-256201-vjzfzshh	69	8	mutant	mutant	JJ
cord-256201-vjzfzshh	69	9	,	,	,
cord-256201-vjzfzshh	69	10	except	except	IN
cord-256201-vjzfzshh	69	11	for	for	IN
cord-256201-vjzfzshh	69	12	the	the	DT
cord-256201-vjzfzshh	69	13	WT	WT	NNP
cord-256201-vjzfzshh	69	14	,	,	,
cord-256201-vjzfzshh	69	15	for	for	IN
cord-256201-vjzfzshh	69	16	which	which	WDT
cord-256201-vjzfzshh	69	17	fifteen	fifteen	CD
cord-256201-vjzfzshh	69	18	tests	test	NNS
cord-256201-vjzfzshh	69	19	were	be	VBD
cord-256201-vjzfzshh	69	20	performed	perform	VBN
cord-256201-vjzfzshh	69	21	.	.	.
cord-256201-vjzfzshh	70	1	Mutation	mutation	NN
cord-256201-vjzfzshh	70	2	rate	rate	NN
cord-256201-vjzfzshh	70	3	estimates	estimate	NNS
cord-256201-vjzfzshh	70	4	for	for	IN
cord-256201-vjzfzshh	70	5	the	the	DT
cord-256201-vjzfzshh	70	6	WT	WT	NNP
cord-256201-vjzfzshh	70	7	in	in	IN
cord-256201-vjzfzshh	70	8	the	the	DT
cord-256201-vjzfzshh	70	9	presence	presence	NN
cord-256201-vjzfzshh	70	10	of	of	IN
cord-256201-vjzfzshh	70	11	5-FU	5-fu	CD
cord-256201-vjzfzshh	70	12	10	10	CD
cord-256201-vjzfzshh	70	13	ng	ng	NNP
cord-256201-vjzfzshh	70	14	/	/	SYM
cord-256201-vjzfzshh	70	15	ml	ml	NNS
cord-256201-vjzfzshh	70	16	were	be	VBD
cord-256201-vjzfzshh	70	17	taken	take	VBN
cord-256201-vjzfzshh	70	18	from	from	IN
cord-256201-vjzfzshh	70	19	a	a	DT
cord-256201-vjzfzshh	70	20	previous	previous	JJ
cord-256201-vjzfzshh	70	21	work	work	NN
cord-256201-vjzfzshh	70	22	(	(	-LRB-
cord-256201-vjzfzshh	70	23	Pereira	Pereira	NNP
cord-256201-vjzfzshh	70	24	-	-	HYPH
cord-256201-vjzfzshh	70	25	Gó	Gó	NNP
cord-256201-vjzfzshh	70	26	mez	mez	NNP
cord-256201-vjzfzshh	70	27	and	and	CC
cord-256201-vjzfzshh	70	28	Sanjuá	Sanjuá	NNP
cord-256201-vjzfzshh	70	29	n	n	NNP
cord-256201-vjzfzshh	70	30	2014	2014	CD
cord-256201-vjzfzshh	70	31	)	)	-RRB-
cord-256201-vjzfzshh	70	32	.	.	.
cord-256201-vjzfzshh	71	1	For	for	IN
cord-256201-vjzfzshh	71	2	fluctuation	fluctuation	NN
cord-256201-vjzfzshh	71	3	tests	test	NNS
cord-256201-vjzfzshh	71	4	performed	perform	VBN
cord-256201-vjzfzshh	71	5	under	under	IN
cord-256201-vjzfzshh	71	6	stress	stress	NN
cord-256201-vjzfzshh	71	7	conditions	condition	NNS
cord-256201-vjzfzshh	71	8	,	,	,
cord-256201-vjzfzshh	71	9	we	-PRON-	PRP
cord-256201-vjzfzshh	71	10	applied	apply	VBD
cord-256201-vjzfzshh	71	11	a	a	DT
cord-256201-vjzfzshh	71	12	correction	correction	NN
cord-256201-vjzfzshh	71	13	for	for	IN
cord-256201-vjzfzshh	71	14	bias	bias	NN
cord-256201-vjzfzshh	71	15	in	in	IN
cord-256201-vjzfzshh	71	16	N	n	CD
cord-256201-vjzfzshh	71	17	1	1	CD
cord-256201-vjzfzshh	71	18	estimation	estimation	NN
cord-256201-vjzfzshh	71	19	which	which	WDT
cord-256201-vjzfzshh	71	20	may	may	MD
cord-256201-vjzfzshh	71	21	result	result	VB
cord-256201-vjzfzshh	71	22	from	from	IN
cord-256201-vjzfzshh	71	23	increased	increase	VBN
cord-256201-vjzfzshh	71	24	viral	viral	JJ
cord-256201-vjzfzshh	71	25	degradation	degradation	NN
cord-256201-vjzfzshh	71	26	relative	relative	JJ
cord-256201-vjzfzshh	71	27	to	to	IN
cord-256201-vjzfzshh	71	28	standard	standard	JJ
cord-256201-vjzfzshh	71	29	conditions	condition	NNS
cord-256201-vjzfzshh	71	30	.	.	.
cord-256201-vjzfzshh	72	1	Following	follow	VBG
cord-256201-vjzfzshh	72	2	previous	previous	JJ
cord-256201-vjzfzshh	72	3	work	work	NN
cord-256201-vjzfzshh	72	4	(	(	-LRB-
cord-256201-vjzfzshh	72	5	Bradwell	Bradwell	NNP
cord-256201-vjzfzshh	72	6	et	et	NNP
cord-256201-vjzfzshh	72	7	al	al	NNP
cord-256201-vjzfzshh	72	8	.	.	NNP
cord-256201-vjzfzshh	72	9	2013	2013	CD
cord-256201-vjzfzshh	72	10	)	)	-RRB-
cord-256201-vjzfzshh	72	11	,	,	,
cord-256201-vjzfzshh	72	12	the	the	DT
cord-256201-vjzfzshh	72	13	probability	probability	NN
cord-256201-vjzfzshh	72	14	of	of	IN
cord-256201-vjzfzshh	72	15	observing	observe	VBG
cord-256201-vjzfzshh	72	16	no	no	DT
cord-256201-vjzfzshh	72	17	mutants	mutant	NNS
cord-256201-vjzfzshh	72	18	was	be	VBD
cord-256201-vjzfzshh	72	19	recalculated	recalculate	VBN
cord-256201-vjzfzshh	72	20	accordingly	accordingly	RB
cord-256201-vjzfzshh	72	21	as	as	IN
cord-256201-vjzfzshh	72	22	where	where	WRB
cord-256201-vjzfzshh	72	23	ź	ź	NN
cord-256201-vjzfzshh	72	24	quantifies	quantify	VBZ
cord-256201-vjzfzshh	72	25	this	this	DT
cord-256201-vjzfzshh	72	26	bias	bias	NN
cord-256201-vjzfzshh	72	27	.	.	.
cord-256201-vjzfzshh	73	1	As	as	IN
cord-256201-vjzfzshh	73	2	an	an	DT
cord-256201-vjzfzshh	73	3	indicator	indicator	NN
cord-256201-vjzfzshh	73	4	of	of	IN
cord-256201-vjzfzshh	73	5	ź	ź	NN
cord-256201-vjzfzshh	73	6	,	,	,
cord-256201-vjzfzshh	73	7	we	-PRON-	PRP
cord-256201-vjzfzshh	73	8	determined	determine	VBD
cord-256201-vjzfzshh	73	9	the	the	DT
cord-256201-vjzfzshh	73	10	relative	relative	JJ
cord-256201-vjzfzshh	73	11	plating	plating	NN
cord-256201-vjzfzshh	73	12	efficiency	efficiency	NN
cord-256201-vjzfzshh	73	13	of	of	IN
cord-256201-vjzfzshh	73	14	the	the	DT
cord-256201-vjzfzshh	73	15	WT	WT	NNP
cord-256201-vjzfzshh	73	16	virus	virus	NN
cord-256201-vjzfzshh	73	17	under	under	IN
cord-256201-vjzfzshh	73	18	the	the	DT
cord-256201-vjzfzshh	73	19	two	two	CD
cord-256201-vjzfzshh	73	20	stress	stress	NN
cord-256201-vjzfzshh	73	21	conditions	condition	NNS
cord-256201-vjzfzshh	73	22	.	.	.
cord-256201-vjzfzshh	74	1	Plating	plating	NN
cord-256201-vjzfzshh	74	2	efficiency	efficiency	NN
cord-256201-vjzfzshh	74	3	was	be	VBD
cord-256201-vjzfzshh	74	4	slightly	slightly	RB
cord-256201-vjzfzshh	74	5	increased	increase	VBN
cord-256201-vjzfzshh	74	6	at	at	IN
cord-256201-vjzfzshh	74	7	42	42	CD
cord-256201-vjzfzshh	74	8	C	C	NNP
cord-256201-vjzfzshh	74	9	(	(	-LRB-
cord-256201-vjzfzshh	74	10	ź	ź	NN
cord-256201-vjzfzshh	74	11	¼	¼	NNP
cord-256201-vjzfzshh	74	12	1.13	1.13	CD
cord-256201-vjzfzshh	74	13	6	6	CD
cord-256201-vjzfzshh	74	14	0.13	0.13	CD
cord-256201-vjzfzshh	74	15	)	)	-RRB-
cord-256201-vjzfzshh	74	16	and	and	CC
cord-256201-vjzfzshh	74	17	reduced	reduce	VBN
cord-256201-vjzfzshh	74	18	in	in	IN
cord-256201-vjzfzshh	74	19	the	the	DT
cord-256201-vjzfzshh	74	20	presence	presence	NN
cord-256201-vjzfzshh	74	21	of	of	IN
cord-256201-vjzfzshh	74	22	10	10	CD
cord-256201-vjzfzshh	74	23	ng	ng	NN
cord-256201-vjzfzshh	74	24	/	/	SYM
cord-256201-vjzfzshh	74	25	ml	ml	NN
cord-256201-vjzfzshh	74	26	5-FU	5-fu	CD
cord-256201-vjzfzshh	75	1	(	(	-LRB-
cord-256201-vjzfzshh	75	2	ź	ź	SYM
cord-256201-vjzfzshh	75	3	¼	¼	CD
cord-256201-vjzfzshh	75	4	0.75	0.75	CD
cord-256201-vjzfzshh	75	5	6	6	CD
cord-256201-vjzfzshh	75	6	0.12	0.12	CD
cord-256201-vjzfzshh	75	7	)	)	-RRB-
cord-256201-vjzfzshh	75	8	.	.	.
cord-256201-vjzfzshh	76	1	We	-PRON-	PRP
cord-256201-vjzfzshh	76	2	therefore	therefore	RB
cord-256201-vjzfzshh	76	3	used	use	VBD
cord-256201-vjzfzshh	76	4	the	the	DT
cord-256201-vjzfzshh	76	5	corresponding	correspond	VBG
cord-256201-vjzfzshh	76	6	ź	ź	NN
cord-256201-vjzfzshh	76	7	values	value	NNS
cord-256201-vjzfzshh	76	8	for	for	IN
cord-256201-vjzfzshh	76	9	calculating	calculate	VBG
cord-256201-vjzfzshh	76	10	mutation	mutation	NN
cord-256201-vjzfzshh	76	11	rates	rate	NNS
cord-256201-vjzfzshh	76	12	at	at	IN
cord-256201-vjzfzshh	76	13	42	42	CD
cord-256201-vjzfzshh	76	14	C	c	NN
cord-256201-vjzfzshh	76	15	and	and	CC
cord-256201-vjzfzshh	76	16	in	in	IN
cord-256201-vjzfzshh	76	17	the	the	DT
cord-256201-vjzfzshh	76	18	presence	presence	NN
cord-256201-vjzfzshh	76	19	of	of	IN
cord-256201-vjzfzshh	76	20	5-FU	5-fu	CD
cord-256201-vjzfzshh	76	21	.	.	.
cord-256201-vjzfzshh	77	1	Since	since	IN
cord-256201-vjzfzshh	77	2	the	the	DT
cord-256201-vjzfzshh	77	3	relative	relative	JJ
cord-256201-vjzfzshh	77	4	plating	plating	NN
cord-256201-vjzfzshh	77	5	efficiencies	efficiency	NNS
cord-256201-vjzfzshh	77	6	of	of	IN
cord-256201-vjzfzshh	77	7	the	the	DT
cord-256201-vjzfzshh	77	8	20GATC	20gatc	CD
cord-256201-vjzfzshh	77	9	virus	virus	NN
cord-256201-vjzfzshh	77	10	did	do	VBD
cord-256201-vjzfzshh	77	11	not	not	RB
cord-256201-vjzfzshh	77	12	differ	differ	VB
cord-256201-vjzfzshh	77	13	significantly	significantly	RB
cord-256201-vjzfzshh	77	14	from	from	IN
cord-256201-vjzfzshh	77	15	those	those	DT
cord-256201-vjzfzshh	77	16	of	of	IN
cord-256201-vjzfzshh	77	17	the	the	DT
cord-256201-vjzfzshh	77	18	WT	WT	NNP
cord-256201-vjzfzshh	77	19	(	(	-LRB-
cord-256201-vjzfzshh	77	20	t	t	NN
cord-256201-vjzfzshh	77	21	-	-	HYPH
cord-256201-vjzfzshh	77	22	test	test	NN
cord-256201-vjzfzshh	77	23	:	:	:
cord-256201-vjzfzshh	77	24	P	p	NN
cord-256201-vjzfzshh	77	25	>	>	XX
cord-256201-vjzfzshh	77	26	0.5	0.5	CD
cord-256201-vjzfzshh	77	27	)	)	-RRB-
cord-256201-vjzfzshh	77	28	,	,	,
cord-256201-vjzfzshh	77	29	we	-PRON-	PRP
cord-256201-vjzfzshh	77	30	used	use	VBD
cord-256201-vjzfzshh	77	31	the	the	DT
cord-256201-vjzfzshh	77	32	same	same	JJ
cord-256201-vjzfzshh	77	33	ź	ź	NN
cord-256201-vjzfzshh	77	34	values	value	NNS
cord-256201-vjzfzshh	77	35	.	.	.
cord-256201-vjzfzshh	78	1	Q	Q	NNP
cord-256201-vjzfzshh	78	2	-	-	HYPH
cord-256201-vjzfzshh	78	3	Q	q	NN
cord-256201-vjzfzshh	78	4	plots	plot	NNS
cord-256201-vjzfzshh	78	5	showed	show	VBD
cord-256201-vjzfzshh	78	6	that	that	IN
cord-256201-vjzfzshh	78	7	mutation	mutation	NN
cord-256201-vjzfzshh	78	8	rate	rate	NN
cord-256201-vjzfzshh	78	9	estimates	estimate	NNS
cord-256201-vjzfzshh	78	10	were	be	VBD
cord-256201-vjzfzshh	78	11	not	not	RB
cord-256201-vjzfzshh	78	12	normally	normally	RB
cord-256201-vjzfzshh	78	13	distributed	distribute	VBN
cord-256201-vjzfzshh	78	14	,	,	,
cord-256201-vjzfzshh	78	15	whereas	whereas	IN
cord-256201-vjzfzshh	78	16	normality	normality	NN
cord-256201-vjzfzshh	78	17	was	be	VBD
cord-256201-vjzfzshh	78	18	satisfied	satisfied	JJ
cord-256201-vjzfzshh	78	19	using	use	VBG
cord-256201-vjzfzshh	78	20	log	log	NN
cord-256201-vjzfzshh	78	21	-	-	HYPH
cord-256201-vjzfzshh	78	22	transformed	transform	VBN
cord-256201-vjzfzshh	78	23	rates	rate	NNS
cord-256201-vjzfzshh	78	24	.	.	.
cord-256201-vjzfzshh	79	1	All	all	DT
cord-256201-vjzfzshh	79	2	statistical	statistical	JJ
cord-256201-vjzfzshh	79	3	tests	test	NNS
cord-256201-vjzfzshh	79	4	were	be	VBD
cord-256201-vjzfzshh	79	5	thus	thus	RB
cord-256201-vjzfzshh	79	6	performed	perform	VBN
cord-256201-vjzfzshh	79	7	using	use	VBG
cord-256201-vjzfzshh	79	8	log	log	NN
cord-256201-vjzfzshh	79	9	-	-	HYPH
cord-256201-vjzfzshh	79	10	transformed	transform	VBN
cord-256201-vjzfzshh	79	11	rates	rate	NNS
cord-256201-vjzfzshh	79	12	.	.	.
cord-256201-vjzfzshh	80	1	The	the	DT
cord-256201-vjzfzshh	80	2	viral	viral	JJ
cord-256201-vjzfzshh	80	3	exponential	exponential	JJ
cord-256201-vjzfzshh	80	4	growth	growth	NN
cord-256201-vjzfzshh	80	5	rate	rate	NN
cord-256201-vjzfzshh	80	6	was	be	VBD
cord-256201-vjzfzshh	80	7	estimated	estimate	VBN
cord-256201-vjzfzshh	80	8	as	as	IN
cord-256201-vjzfzshh	80	9	r	r	NNP
cord-256201-vjzfzshh	80	10	¼	¼	NNP
cord-256201-vjzfzshh	80	11	ln(N	ln(N	NNP
cord-256201-vjzfzshh	80	12	1	1	CD
cord-256201-vjzfzshh	80	13	/	/	SYM
cord-256201-vjzfzshh	80	14	N	n	CD
cord-256201-vjzfzshh	80	15	0	0	CD
cord-256201-vjzfzshh	80	16	)	)	-RRB-
cord-256201-vjzfzshh	81	1	/t	/t	NNP
cord-256201-vjzfzshh	81	2	,	,	,
cord-256201-vjzfzshh	81	3	where	where	WRB
cord-256201-vjzfzshh	81	4	N	n	CD
cord-256201-vjzfzshh	81	5	1	1	CD
cord-256201-vjzfzshh	81	6	and	and	CC
cord-256201-vjzfzshh	81	7	N	n	CD
cord-256201-vjzfzshh	81	8	0	0	CD
cord-256201-vjzfzshh	81	9	were	be	VBD
cord-256201-vjzfzshh	81	10	obtained	obtain	VBN
cord-256201-vjzfzshh	81	11	from	from	IN
cord-256201-vjzfzshh	81	12	the	the	DT
cord-256201-vjzfzshh	81	13	fluctuation	fluctuation	NN
cord-256201-vjzfzshh	81	14	test	test	NN
cord-256201-vjzfzshh	81	15	assays	assay	NNS
cord-256201-vjzfzshh	81	16	,	,	,
cord-256201-vjzfzshh	81	17	and	and	CC
cord-256201-vjzfzshh	82	1	t	t	NNP
cord-256201-vjzfzshh	82	2	is	be	VBZ
cord-256201-vjzfzshh	82	3	the	the	DT
cord-256201-vjzfzshh	82	4	incubation	incubation	NN
cord-256201-vjzfzshh	82	5	time	time	NN
cord-256201-vjzfzshh	82	6	in	in	IN
cord-256201-vjzfzshh	82	7	hours	hour	NNS
cord-256201-vjzfzshh	82	8	.	.	.
cord-256201-vjzfzshh	83	1	Q	Q	NNP
cord-256201-vjzfzshh	83	2	-	-	HYPH
cord-256201-vjzfzshh	83	3	Q	q	NN
cord-256201-vjzfzshh	83	4	plots	plot	NNS
cord-256201-vjzfzshh	83	5	indicated	indicate	VBD
cord-256201-vjzfzshh	83	6	that	that	IN
cord-256201-vjzfzshh	83	7	growth	growth	NN
cord-256201-vjzfzshh	83	8	rates	rate	NNS
cord-256201-vjzfzshh	83	9	were	be	VBD
cord-256201-vjzfzshh	83	10	normally	normally	RB
cord-256201-vjzfzshh	83	11	distributed	distribute	VBN
cord-256201-vjzfzshh	83	12	.	.	.
cord-256201-vjzfzshh	84	1	The	the	DT
cord-256201-vjzfzshh	84	2	/X174	/X174	NFP
cord-256201-vjzfzshh	84	3	dsDNA	dsdna	RB
cord-256201-vjzfzshh	84	4	replicative	replicative	JJ
cord-256201-vjzfzshh	84	5	form	form	NN
cord-256201-vjzfzshh	84	6	was	be	VBD
cord-256201-vjzfzshh	84	7	quantified	quantify	VBN
cord-256201-vjzfzshh	84	8	using	use	VBG
cord-256201-vjzfzshh	84	9	the	the	DT
cord-256201-vjzfzshh	84	10	Quant	Quant	NNP
cord-256201-vjzfzshh	84	11	-	-	:
cord-256201-vjzfzshh	84	12	iT	it	PRP
cord-256201-vjzfzshh	84	13	PicoGreen	PicoGreen	NNP
cord-256201-vjzfzshh	84	14	dsDNA	dsdna	RB
cord-256201-vjzfzshh	84	15	broad	broad	JJ
cord-256201-vjzfzshh	84	16	range	range	NN
cord-256201-vjzfzshh	84	17	assay	assay	NN
cord-256201-vjzfzshh	84	18	kit	kit	NN
cord-256201-vjzfzshh	84	19	(	(	-LRB-
cord-256201-vjzfzshh	84	20	Life	Life	NNP
cord-256201-vjzfzshh	84	21	technologies	technology	NNS
cord-256201-vjzfzshh	84	22	)	)	-RRB-
cord-256201-vjzfzshh	84	23	,	,	,
cord-256201-vjzfzshh	84	24	and	and	CC
cord-256201-vjzfzshh	84	25	all	all	DT
cord-256201-vjzfzshh	84	26	extracts	extract	NNS
cord-256201-vjzfzshh	84	27	were	be	VBD
cord-256201-vjzfzshh	84	28	brought	bring	VBN
cord-256201-vjzfzshh	84	29	to	to	IN
cord-256201-vjzfzshh	84	30	the	the	DT
cord-256201-vjzfzshh	84	31	same	same	JJ
cord-256201-vjzfzshh	84	32	concentration	concentration	NN
cord-256201-vjzfzshh	84	33	(	(	-LRB-
cord-256201-vjzfzshh	84	34	30	30	CD
cord-256201-vjzfzshh	84	35	ng	ng	NN
cord-256201-vjzfzshh	84	36	/	/	SYM
cord-256201-vjzfzshh	84	37	ml	ml	NN
cord-256201-vjzfzshh	84	38	)	)	-RRB-
cord-256201-vjzfzshh	84	39	.	.	.
cord-256201-vjzfzshh	85	1	DNA	DNA	NNP
cord-256201-vjzfzshh	85	2	from	from	IN
cord-256201-vjzfzshh	85	3	each	each	DT
cord-256201-vjzfzshh	85	4	virus	virus	NN
cord-256201-vjzfzshh	85	5	was	be	VBD
cord-256201-vjzfzshh	85	6	split	split	VBN
cord-256201-vjzfzshh	85	7	into	into	IN
cord-256201-vjzfzshh	85	8	three	three	CD
cord-256201-vjzfzshh	85	9	aliquots	aliquot	NNS
cord-256201-vjzfzshh	85	10	,	,	,
cord-256201-vjzfzshh	85	11	which	which	WDT
cord-256201-vjzfzshh	85	12	were	be	VBD
cord-256201-vjzfzshh	85	13	treated	treat	VBN
cord-256201-vjzfzshh	85	14	with	with	IN
cord-256201-vjzfzshh	85	15	XhoI	XhoI	NNP
cord-256201-vjzfzshh	85	16	to	to	TO
cord-256201-vjzfzshh	85	17	linearize	linearize	VB
cord-256201-vjzfzshh	85	18	the	the	DT
cord-256201-vjzfzshh	85	19	genome	genome	NN
cord-256201-vjzfzshh	85	20	,	,	,
cord-256201-vjzfzshh	85	21	with	with	IN
cord-256201-vjzfzshh	85	22	XhoI	XhoI	NNP
cord-256201-vjzfzshh	85	23	and	and	CC
cord-256201-vjzfzshh	85	24	DpnI	DpnI	NNP
cord-256201-vjzfzshh	85	25	to	to	TO
cord-256201-vjzfzshh	85	26	digest	digest	VB
cord-256201-vjzfzshh	85	27	methylated	methylated	JJ
cord-256201-vjzfzshh	85	28	GATCs	GATCs	NNP
cord-256201-vjzfzshh	85	29	,	,	,
cord-256201-vjzfzshh	85	30	or	or	CC
cord-256201-vjzfzshh	85	31	with	with	IN
cord-256201-vjzfzshh	85	32	XhoI	XhoI	NNP
cord-256201-vjzfzshh	85	33	and	and	CC
cord-256201-vjzfzshh	85	34	MboI	MboI	NNP
cord-256201-vjzfzshh	85	35	(	(	-LRB-
cord-256201-vjzfzshh	85	36	i.e.	i.e.	FW
cord-256201-vjzfzshh	85	37	,	,	,
cord-256201-vjzfzshh	85	38	DpnII	DpnII	NNP
cord-256201-vjzfzshh	85	39	)	)	-RRB-
cord-256201-vjzfzshh	85	40	to	to	TO
cord-256201-vjzfzshh	85	41	digest	digest	VB
cord-256201-vjzfzshh	85	42	non	non	JJ
cord-256201-vjzfzshh	85	43	-	-	JJ
cord-256201-vjzfzshh	85	44	methylated	methylated	JJ
cord-256201-vjzfzshh	85	45	GATCs	gatc	NNS
cord-256201-vjzfzshh	85	46	.	.	.
cord-256201-vjzfzshh	86	1	Double	double	JJ
cord-256201-vjzfzshh	86	2	digestions	digestion	NNS
cord-256201-vjzfzshh	86	3	were	be	VBD
cord-256201-vjzfzshh	86	4	performed	perform	VBN
cord-256201-vjzfzshh	86	5	according	accord	VBG
cord-256201-vjzfzshh	86	6	to	to	IN
cord-256201-vjzfzshh	86	7	the	the	DT
cord-256201-vjzfzshh	86	8	manufacturer	manufacturer	NN
cord-256201-vjzfzshh	86	9	instructions	instruction	NNS
cord-256201-vjzfzshh	86	10	(	(	-LRB-
cord-256201-vjzfzshh	86	11	Thermoscientific	Thermoscientific	NNP
cord-256201-vjzfzshh	86	12	)	)	-RRB-
cord-256201-vjzfzshh	86	13	.	.	.
cord-256201-vjzfzshh	87	1	A	a	DT
cord-256201-vjzfzshh	87	2	standard	standard	JJ
cord-256201-vjzfzshh	87	3	plasmid	plasmid	NN
cord-256201-vjzfzshh	87	4	(	(	-LRB-
cord-256201-vjzfzshh	87	5	pIRES	pIRES	NNP
cord-256201-vjzfzshh	87	6	,	,	,
cord-256201-vjzfzshh	87	7	Clontech	Clontech	NNP
cord-256201-vjzfzshh	87	8	)	)	-RRB-
cord-256201-vjzfzshh	87	9	was	be	VBD
cord-256201-vjzfzshh	87	10	used	use	VBN
cord-256201-vjzfzshh	87	11	as	as	IN
cord-256201-vjzfzshh	87	12	a	a	DT
cord-256201-vjzfzshh	87	13	digestion	digestion	NN
cord-256201-vjzfzshh	87	14	control	control	NN
cord-256201-vjzfzshh	87	15	(	(	-LRB-
cord-256201-vjzfzshh	87	16	not	not	RB
cord-256201-vjzfzshh	87	17	shown	show	VBN
cord-256201-vjzfzshh	87	18	)	)	-RRB-
cord-256201-vjzfzshh	87	19	.	.	.
cord-256201-vjzfzshh	88	1	A	a	DT
cord-256201-vjzfzshh	88	2	monochrome	monochrome	JJ
cord-256201-vjzfzshh	88	3	picture	picture	NN
cord-256201-vjzfzshh	88	4	of	of	IN
cord-256201-vjzfzshh	88	5	the	the	DT
cord-256201-vjzfzshh	88	6	gel	gel	NN
cord-256201-vjzfzshh	88	7	was	be	VBD
cord-256201-vjzfzshh	88	8	transformed	transform	VBN
cord-256201-vjzfzshh	88	9	to	to	IN
cord-256201-vjzfzshh	88	10	an	an	DT
cord-256201-vjzfzshh	88	11	eight	eight	CD
cord-256201-vjzfzshh	88	12	-	-	HYPH
cord-256201-vjzfzshh	88	13	bit	bit	NN
cord-256201-vjzfzshh	88	14	image	image	NN
cord-256201-vjzfzshh	88	15	,	,	,
cord-256201-vjzfzshh	88	16	and	and	CC
cord-256201-vjzfzshh	88	17	the	the	DT
cord-256201-vjzfzshh	88	18	pixel	pixel	NN
cord-256201-vjzfzshh	88	19	area	area	NN
cord-256201-vjzfzshh	88	20	and	and	CC
cord-256201-vjzfzshh	88	21	intensity	intensity	NN
cord-256201-vjzfzshh	88	22	of	of	IN
cord-256201-vjzfzshh	88	23	each	each	DT
cord-256201-vjzfzshh	88	24	band	band	NN
cord-256201-vjzfzshh	88	25	were	be	VBD
cord-256201-vjzfzshh	88	26	quantified	quantify	VBN
cord-256201-vjzfzshh	88	27	using	use	VBG
cord-256201-vjzfzshh	88	28	ImageJ.	ImageJ.	NNP
cord-256201-vjzfzshh	89	1	Given	give	VBN
cord-256201-vjzfzshh	89	2	the	the	DT
cord-256201-vjzfzshh	89	3	size	size	NN
cord-256201-vjzfzshh	89	4	and	and	CC
cord-256201-vjzfzshh	89	5	base	base	NN
cord-256201-vjzfzshh	89	6	composition	composition	NN
cord-256201-vjzfzshh	89	7	of	of	IN
cord-256201-vjzfzshh	89	8	the	the	DT
cord-256201-vjzfzshh	89	9	/X174	/X174	NFP
cord-256201-vjzfzshh	89	10	DNA	DNA	NNP
cord-256201-vjzfzshh	89	11	(	(	-LRB-
cord-256201-vjzfzshh	89	12	5,386	5,386	CD
cord-256201-vjzfzshh	89	13	bases	basis	NNS
cord-256201-vjzfzshh	89	14	,	,	,
cord-256201-vjzfzshh	89	15	31.3	31.3	CD
cord-256201-vjzfzshh	89	16	%	%	NN
cord-256201-vjzfzshh	89	17	T	T	NNP
cord-256201-vjzfzshh	89	18	,	,	,
cord-256201-vjzfzshh	89	19	24.0	24.0	CD
cord-256201-vjzfzshh	89	20	%	%	NN
cord-256201-vjzfzshh	89	21	A	a	NN
cord-256201-vjzfzshh	89	22	,	,	,
cord-256201-vjzfzshh	89	23	23.2	23.2	CD
cord-256201-vjzfzshh	89	24	%	%	NN
cord-256201-vjzfzshh	89	25	G	g	NN
cord-256201-vjzfzshh	89	26	,	,	,
cord-256201-vjzfzshh	89	27	and	and	CC
cord-256201-vjzfzshh	89	28	21.5	21.5	CD
cord-256201-vjzfzshh	89	29	%	%	NN
cord-256201-vjzfzshh	89	30	C	C	NNP
cord-256201-vjzfzshh	89	31	)	)	-RRB-
cord-256201-vjzfzshh	89	32	,	,	,
cord-256201-vjzfzshh	89	33	the	the	DT
cord-256201-vjzfzshh	89	34	expected	expect	VBN
cord-256201-vjzfzshh	89	35	number	number	NN
cord-256201-vjzfzshh	89	36	of	of	IN
cord-256201-vjzfzshh	89	37	GATC	GATC	NNP
cord-256201-vjzfzshh	89	38	sequence	sequence	NN
cord-256201-vjzfzshh	89	39	motifs	motif	NNS
cord-256201-vjzfzshh	89	40	in	in	IN
cord-256201-vjzfzshh	89	41	its	-PRON-	PRP$
cord-256201-vjzfzshh	89	42	genome	genome	NN
cord-256201-vjzfzshh	89	43	is	be	VBZ
cord-256201-vjzfzshh	89	44	0.313	0.313	CD
cord-256201-vjzfzshh	89	45	Â	â	CD
cord-256201-vjzfzshh	89	46	0.240	0.240	CD
cord-256201-vjzfzshh	90	1	Â	â	NN
cord-256201-vjzfzshh	90	2	0.232	0.232	CD
cord-256201-vjzfzshh	90	3	Â	â	NN
cord-256201-vjzfzshh	90	4	0.215	0.215	CD
cord-256201-vjzfzshh	90	5	Â	â	CD
cord-256201-vjzfzshh	90	6	5,386	5,386	CD
cord-256201-vjzfzshh	90	7	¼	¼	CD
cord-256201-vjzfzshh	90	8	20.18	20.18	CD
cord-256201-vjzfzshh	90	9	.	.	.
cord-256201-vjzfzshh	91	1	The	the	DT
cord-256201-vjzfzshh	91	2	Poisson	Poisson	NNP
cord-256201-vjzfzshh	91	3	probability	probability	NN
cord-256201-vjzfzshh	91	4	of	of	IN
cord-256201-vjzfzshh	91	5	observing	observe	VBG
cord-256201-vjzfzshh	91	6	no	no	DT
cord-256201-vjzfzshh	91	7	GATC	GATC	NNP
cord-256201-vjzfzshh	91	8	motifs	motif	NNS
cord-256201-vjzfzshh	91	9	is	be	VBZ
cord-256201-vjzfzshh	91	10	extremely	extremely	RB
cord-256201-vjzfzshh	91	11	low	low	JJ
cord-256201-vjzfzshh	92	1	(	(	-LRB-
cord-256201-vjzfzshh	92	2	P	p	NN
cord-256201-vjzfzshh	92	3	¼	¼	CD
cord-256201-vjzfzshh	92	4	1.72	1.72	CD
cord-256201-vjzfzshh	92	5	Â	â	CD
cord-256201-vjzfzshh	92	6	10	10	CD
cord-256201-vjzfzshh	92	7	-9	-9	NNP
cord-256201-vjzfzshh	92	8	)	)	-RRB-
cord-256201-vjzfzshh	92	9	,	,	,
cord-256201-vjzfzshh	92	10	thus	thus	RB
cord-256201-vjzfzshh	92	11	indicating	indicate	VBG
cord-256201-vjzfzshh	92	12	a	a	DT
cord-256201-vjzfzshh	92	13	strong	strong	JJ
cord-256201-vjzfzshh	92	14	avoidance	avoidance	NN
cord-256201-vjzfzshh	92	15	of	of	IN
cord-256201-vjzfzshh	92	16	these	these	DT
cord-256201-vjzfzshh	92	17	motifs	motif	NNS
cord-256201-vjzfzshh	92	18	.	.	.
cord-256201-vjzfzshh	93	1	To	to	TO
cord-256201-vjzfzshh	93	2	restore	restore	VB
cord-256201-vjzfzshh	93	3	GATC	GATC	NNP
cord-256201-vjzfzshh	93	4	usage	usage	NN
cord-256201-vjzfzshh	93	5	in	in	IN
cord-256201-vjzfzshh	93	6	/X174	/X174	NNP
cord-256201-vjzfzshh	93	7	,	,	,
cord-256201-vjzfzshh	93	8	we	-PRON-	PRP
cord-256201-vjzfzshh	93	9	created	create	VBD
cord-256201-vjzfzshh	93	10	a	a	DT
cord-256201-vjzfzshh	93	11	mutant	mutant	JJ
cord-256201-vjzfzshh	93	12	phage	phage	NN
cord-256201-vjzfzshh	93	13	carrying	carry	VBG
cord-256201-vjzfzshh	93	14	twenty	twenty	CD
cord-256201-vjzfzshh	93	15	GATCs	gatc	NNS
cord-256201-vjzfzshh	93	16	by	by	IN
cord-256201-vjzfzshh	93	17	sequential	sequential	JJ
cord-256201-vjzfzshh	93	18	addition	addition	NN
cord-256201-vjzfzshh	93	19	of	of	IN
cord-256201-vjzfzshh	93	20	these	these	DT
cord-256201-vjzfzshh	93	21	sites	site	NNS
cord-256201-vjzfzshh	93	22	into	into	IN
cord-256201-vjzfzshh	93	23	the	the	DT
cord-256201-vjzfzshh	93	24	WT	WT	NNP
cord-256201-vjzfzshh	93	25	virus	virus	NN
cord-256201-vjzfzshh	93	26	using	use	VBG
cord-256201-vjzfzshh	93	27	site	site	NN
cord-256201-vjzfzshh	93	28	-	-	HYPH
cord-256201-vjzfzshh	93	29	directed	direct	VBN
cord-256201-vjzfzshh	93	30	mutagenesis	mutagenesis	NN
cord-256201-vjzfzshh	93	31	(	(	-LRB-
cord-256201-vjzfzshh	93	32	Fig	Fig	NNP
cord-256201-vjzfzshh	93	33	.	.	.
cord-256201-vjzfzshh	93	34	1	1	CD
cord-256201-vjzfzshh	93	35	)	)	-RRB-
cord-256201-vjzfzshh	93	36	.	.	.
cord-256201-vjzfzshh	94	1	The	the	DT
cord-256201-vjzfzshh	94	2	twenty	twenty	CD
cord-256201-vjzfzshh	94	3	GATC	GATC	NNP
cord-256201-vjzfzshh	94	4	motifs	motif	NNS
cord-256201-vjzfzshh	94	5	were	be	VBD
cord-256201-vjzfzshh	94	6	evenly	evenly	RB
cord-256201-vjzfzshh	94	7	distributed	distribute	VBN
cord-256201-vjzfzshh	94	8	throughout	throughout	IN
cord-256201-vjzfzshh	94	9	the	the	DT
cord-256201-vjzfzshh	94	10	phage	phage	NN
cord-256201-vjzfzshh	94	11	genome	genome	NN
cord-256201-vjzfzshh	94	12	,	,	,
cord-256201-vjzfzshh	94	13	the	the	DT
cord-256201-vjzfzshh	94	14	greatest	great	JJS
cord-256201-vjzfzshh	94	15	distance	distance	NN
cord-256201-vjzfzshh	94	16	between	between	IN
cord-256201-vjzfzshh	94	17	any	any	DT
cord-256201-vjzfzshh	94	18	two	two	CD
cord-256201-vjzfzshh	94	19	consecutive	consecutive	JJ
cord-256201-vjzfzshh	94	20	of	of	IN
cord-256201-vjzfzshh	94	21	them	-PRON-	PRP
cord-256201-vjzfzshh	94	22	being	be	VBG
cord-256201-vjzfzshh	94	23	456	456	CD
cord-256201-vjzfzshh	94	24	bases	basis	NNS
cord-256201-vjzfzshh	94	25	and	and	CC
cord-256201-vjzfzshh	94	26	,	,	,
cord-256201-vjzfzshh	94	27	wherein	wherein	WRB
cord-256201-vjzfzshh	94	28	possible	possible	JJ
cord-256201-vjzfzshh	94	29	,	,	,
cord-256201-vjzfzshh	94	30	substitutions	substitution	NNS
cord-256201-vjzfzshh	94	31	were	be	VBD
cord-256201-vjzfzshh	94	32	made	make	VBN
cord-256201-vjzfzshh	94	33	synonymous	synonymous	JJ
cord-256201-vjzfzshh	94	34	to	to	TO
cord-256201-vjzfzshh	94	35	minimize	minimize	VB
cord-256201-vjzfzshh	94	36	their	-PRON-	PRP$
cord-256201-vjzfzshh	94	37	effects	effect	NNS
cord-256201-vjzfzshh	94	38	on	on	IN
cord-256201-vjzfzshh	94	39	protein	protein	NN
cord-256201-vjzfzshh	94	40	function	function	NN
cord-256201-vjzfzshh	94	41	.	.	.
cord-256201-vjzfzshh	95	1	Given	give	VBN
cord-256201-vjzfzshh	95	2	that	that	IN
cord-256201-vjzfzshh	95	3	the	the	DT
cord-256201-vjzfzshh	95	4	Dam	Dam	NNP
cord-256201-vjzfzshh	95	5	/	/	SYM
cord-256201-vjzfzshh	95	6	MutHLS	muthls	NN
cord-256201-vjzfzshh	95	7	system	system	NN
cord-256201-vjzfzshh	95	8	can	can	MD
cord-256201-vjzfzshh	95	9	perform	perform	VB
cord-256201-vjzfzshh	95	10	MMR	MMR	NNP
cord-256201-vjzfzshh	95	11	at	at	IN
cord-256201-vjzfzshh	95	12	a	a	DT
cord-256201-vjzfzshh	95	13	distance	distance	NN
cord-256201-vjzfzshh	95	14	of	of	IN
cord-256201-vjzfzshh	95	15	up	up	IN
cord-256201-vjzfzshh	95	16	to	to	TO
cord-256201-vjzfzshh	95	17	1	1	CD
cord-256201-vjzfzshh	95	18	kb	kb	NNS
cord-256201-vjzfzshh	95	19	from	from	IN
cord-256201-vjzfzshh	95	20	a	a	DT
cord-256201-vjzfzshh	95	21	GATC	GATC	NNP
cord-256201-vjzfzshh	95	22	(	(	-LRB-
cord-256201-vjzfzshh	95	23	Modrich	Modrich	NNP
cord-256201-vjzfzshh	95	24	and	and	CC
cord-256201-vjzfzshh	95	25	Lahue	Lahue	NNP
cord-256201-vjzfzshh	95	26	1996	1996	CD
cord-256201-vjzfzshh	95	27	)	)	-RRB-
cord-256201-vjzfzshh	95	28	,	,	,
cord-256201-vjzfzshh	95	29	the	the	DT
cord-256201-vjzfzshh	95	30	number	number	NN
cord-256201-vjzfzshh	95	31	and	and	CC
cord-256201-vjzfzshh	95	32	distribution	distribution	NN
cord-256201-vjzfzshh	95	33	of	of	IN
cord-256201-vjzfzshh	95	34	the	the	DT
cord-256201-vjzfzshh	95	35	introduced	introduce	VBN
cord-256201-vjzfzshh	95	36	GATCs	GATCs	NNP
cord-256201-vjzfzshh	95	37	should	should	MD
cord-256201-vjzfzshh	95	38	allow	allow	VB
cord-256201-vjzfzshh	95	39	for	for	IN
cord-256201-vjzfzshh	95	40	efficient	efficient	JJ
cord-256201-vjzfzshh	95	41	MMR	MMR	NNP
cord-256201-vjzfzshh	95	42	in	in	IN
cord-256201-vjzfzshh	95	43	the	the	DT
cord-256201-vjzfzshh	95	44	entire	entire	JJ
cord-256201-vjzfzshh	95	45	phage	phage	NN
cord-256201-vjzfzshh	95	46	genome	genome	NN
cord-256201-vjzfzshh	95	47	.	.	.
cord-256201-vjzfzshh	96	1	To	to	TO
cord-256201-vjzfzshh	96	2	test	test	VB
cord-256201-vjzfzshh	96	3	the	the	DT
cord-256201-vjzfzshh	96	4	effect	effect	NN
cord-256201-vjzfzshh	96	5	of	of	IN
cord-256201-vjzfzshh	96	6	GATCs	GATCs	NNP
cord-256201-vjzfzshh	96	7	on	on	IN
cord-256201-vjzfzshh	96	8	the	the	DT
cord-256201-vjzfzshh	96	9	viral	viral	JJ
cord-256201-vjzfzshh	96	10	mutation	mutation	NN
cord-256201-vjzfzshh	96	11	rate	rate	NN
cord-256201-vjzfzshh	96	12	,	,	,
cord-256201-vjzfzshh	96	13	we	-PRON-	PRP
cord-256201-vjzfzshh	96	14	performed	perform	VBD
cord-256201-vjzfzshh	96	15	Luria	Luria	NNP
cord-256201-vjzfzshh	96	16	-	-	HYPH
cord-256201-vjzfzshh	96	17	Delbrü	Delbrü	NNP
cord-256201-vjzfzshh	96	18	ck	ck	POS
cord-256201-vjzfzshh	96	19	fluctuation	fluctuation	NN
cord-256201-vjzfzshh	96	20	tests	test	NNS
cord-256201-vjzfzshh	96	21	for	for	IN
cord-256201-vjzfzshh	96	22	the	the	DT
cord-256201-vjzfzshh	96	23	WT	WT	NNP
cord-256201-vjzfzshh	96	24	and	and	CC
cord-256201-vjzfzshh	96	25	20GATC	20gatc	CD
cord-256201-vjzfzshh	96	26	viruses	virus	NNS
cord-256201-vjzfzshh	96	27	.	.	.
cord-256201-vjzfzshh	97	1	To	to	TO
cord-256201-vjzfzshh	97	2	score	score	VB
cord-256201-vjzfzshh	97	3	mutants	mutant	NNS
cord-256201-vjzfzshh	97	4	phenotypically	phenotypically	RB
cord-256201-vjzfzshh	97	5	,	,	,
cord-256201-vjzfzshh	97	6	we	-PRON-	PRP
cord-256201-vjzfzshh	97	7	used	use	VBD
cord-256201-vjzfzshh	97	8	the	the	DT
cord-256201-vjzfzshh	97	9	non	non	JJ
cord-256201-vjzfzshh	97	10	-	-	JJ
cord-256201-vjzfzshh	97	11	permissive	permissive	JJ
cord-256201-vjzfzshh	97	12	E.	E.	NNP
cord-256201-vjzfzshh	97	13	coli	coli	NNS
cord-256201-vjzfzshh	97	14	C	c	NN
cord-256201-vjzfzshh	97	15	mutant	mutant	NN
cord-256201-vjzfzshh	97	16	gro87	gro87	CD
cord-256201-vjzfzshh	97	17	,	,	,
cord-256201-vjzfzshh	97	18	which	which	WDT
cord-256201-vjzfzshh	97	19	carries	carry	VBZ
cord-256201-vjzfzshh	97	20	a	a	DT
cord-256201-vjzfzshh	97	21	mutation	mutation	NN
cord-256201-vjzfzshh	97	22	in	in	IN
cord-256201-vjzfzshh	97	23	the	the	DT
cord-256201-vjzfzshh	97	24	DNA	dna	NN
cord-256201-vjzfzshh	97	25	helicase	helicase	NN
cord-256201-vjzfzshh	97	26	gene	gene	NN
cord-256201-vjzfzshh	97	27	rep	rep	NNP
cord-256201-vjzfzshh	97	28	that	that	WDT
cord-256201-vjzfzshh	97	29	blocks	block	VBZ
cord-256201-vjzfzshh	97	30	stage	stage	NN
cord-256201-vjzfzshh	97	31	III	III	NNP
cord-256201-vjzfzshh	97	32	ssDNA	ssdna	NN
cord-256201-vjzfzshh	97	33	synthesis	synthesis	NN
cord-256201-vjzfzshh	97	34	,	,	,
cord-256201-vjzfzshh	97	35	preventing	prevent	VBG
cord-256201-vjzfzshh	97	36	maturation	maturation	NN
cord-256201-vjzfzshh	97	37	of	of	IN
cord-256201-vjzfzshh	97	38	the	the	DT
cord-256201-vjzfzshh	97	39	WT	WT	NNP
cord-256201-vjzfzshh	97	40	phage	phage	NN
cord-256201-vjzfzshh	97	41	(	(	-LRB-
cord-256201-vjzfzshh	97	42	Ekechukwu	Ekechukwu	NNP
cord-256201-vjzfzshh	97	43	,	,	,
cord-256201-vjzfzshh	97	44	Oberste	Oberste	NNP
cord-256201-vjzfzshh	97	45	,	,	,
cord-256201-vjzfzshh	97	46	and	and	CC
cord-256201-vjzfzshh	97	47	Fane	Fane	NNP
cord-256201-vjzfzshh	97	48	1995	1995	CD
cord-256201-vjzfzshh	97	49	)	)	-RRB-
cord-256201-vjzfzshh	97	50	.	.	.
cord-256201-vjzfzshh	98	1	The	the	DT
cord-256201-vjzfzshh	98	2	phage	phage	NN
cord-256201-vjzfzshh	98	3	can	can	MD
cord-256201-vjzfzshh	98	4	overcome	overcome	VB
cord-256201-vjzfzshh	98	5	this	this	DT
cord-256201-vjzfzshh	98	6	restriction	restriction	NN
cord-256201-vjzfzshh	98	7	by	by	IN
cord-256201-vjzfzshh	98	8	changing	change	VBG
cord-256201-vjzfzshh	98	9	certain	certain	JJ
cord-256201-vjzfzshh	98	10	amino	amino	NN
cord-256201-vjzfzshh	98	11	acid	acid	NN
cord-256201-vjzfzshh	98	12	residues	residue	NNS
cord-256201-vjzfzshh	98	13	in	in	IN
cord-256201-vjzfzshh	98	14	the	the	DT
cord-256201-vjzfzshh	98	15	N	n	CD
cord-256201-vjzfzshh	98	16	-	-	HYPH
cord-256201-vjzfzshh	98	17	terminal	terminal	NN
cord-256201-vjzfzshh	98	18	region	region	NN
cord-256201-vjzfzshh	98	19	of	of	IN
cord-256201-vjzfzshh	98	20	protein	protein	NN
cord-256201-vjzfzshh	98	21	A	A	NNP
cord-256201-vjzfzshh	98	22	,	,	,
cord-256201-vjzfzshh	98	23	an	an	DT
cord-256201-vjzfzshh	98	24	endonuclease	endonuclease	NN
cord-256201-vjzfzshh	98	25	that	that	WDT
cord-256201-vjzfzshh	98	26	nicks	nick	VBZ
cord-256201-vjzfzshh	98	27	the	the	DT
cord-256201-vjzfzshh	98	28	negative	negative	JJ
cord-256201-vjzfzshh	98	29	strand	strand	NN
cord-256201-vjzfzshh	98	30	of	of	IN
cord-256201-vjzfzshh	98	31	the	the	DT
cord-256201-vjzfzshh	98	32	supercoiled	supercoiled	JJ
cord-256201-vjzfzshh	98	33	phage	phage	NN
cord-256201-vjzfzshh	98	34	DNA	dna	NN
cord-256201-vjzfzshh	98	35	,	,	,
cord-256201-vjzfzshh	98	36	and	and	CC
cord-256201-vjzfzshh	98	37	these	these	DT
cord-256201-vjzfzshh	98	38	protein	protein	NN
cord-256201-vjzfzshh	98	39	changes	change	NNS
cord-256201-vjzfzshh	98	40	can	can	MD
cord-256201-vjzfzshh	98	41	be	be	VB
cord-256201-vjzfzshh	98	42	conferred	confer	VBN
cord-256201-vjzfzshh	98	43	by	by	IN
cord-256201-vjzfzshh	98	44	at	at	RB
cord-256201-vjzfzshh	98	45	least	least	RBS
cord-256201-vjzfzshh	98	46	seven	seven	CD
cord-256201-vjzfzshh	98	47	different	different	JJ
cord-256201-vjzfzshh	98	48	nucleotide	nucleotide	JJ
cord-256201-vjzfzshh	98	49	substitutions	substitution	NNS
cord-256201-vjzfzshh	98	50	(	(	-LRB-
cord-256201-vjzfzshh	98	51	Cuevas	Cuevas	NNP
cord-256201-vjzfzshh	98	52	,	,	,
cord-256201-vjzfzshh	98	53	Duffy	Duffy	NNP
cord-256201-vjzfzshh	98	54	,	,	,
cord-256201-vjzfzshh	98	55	and	and	CC
cord-256201-vjzfzshh	98	56	Sanjuá	Sanjuá	NNP
cord-256201-vjzfzshh	98	57	n	n	NNP
cord-256201-vjzfzshh	98	58	2009	2009	CD
cord-256201-vjzfzshh	98	59	)	)	-RRB-
cord-256201-vjzfzshh	98	60	.	.	.
cord-256201-vjzfzshh	99	1	By	by	IN
cord-256201-vjzfzshh	99	2	growing	grow	VBG
cord-256201-vjzfzshh	99	3	the	the	DT
cord-256201-vjzfzshh	99	4	virus	virus	NN
cord-256201-vjzfzshh	99	5	in	in	IN
cord-256201-vjzfzshh	99	6	permissive	permissive	JJ
cord-256201-vjzfzshh	99	7	cells	cell	NNS
cord-256201-vjzfzshh	99	8	and	and	CC
cord-256201-vjzfzshh	99	9	performing	perform	VBG
cord-256201-vjzfzshh	99	10	plaque	plaque	NN
cord-256201-vjzfzshh	99	11	assays	assay	NNS
cord-256201-vjzfzshh	99	12	in	in	IN
cord-256201-vjzfzshh	99	13	gro87	gro87	CD
cord-256201-vjzfzshh	99	14	cells	cell	NNS
cord-256201-vjzfzshh	99	15	to	to	TO
cord-256201-vjzfzshh	99	16	score	score	VB
cord-256201-vjzfzshh	99	17	mutations	mutation	NNS
cord-256201-vjzfzshh	99	18	,	,	,
cord-256201-vjzfzshh	99	19	we	-PRON-	PRP
cord-256201-vjzfzshh	99	20	obtained	obtain	VBD
cord-256201-vjzfzshh	99	21	an	an	DT
cord-256201-vjzfzshh	99	22	estimated	estimate	VBN
cord-256201-vjzfzshh	99	23	mutation	mutation	NN
cord-256201-vjzfzshh	99	24	rate	rate	NN
cord-256201-vjzfzshh	99	25	for	for	IN
cord-256201-vjzfzshh	99	26	the	the	DT
cord-256201-vjzfzshh	99	27	WT	WT	NNP
cord-256201-vjzfzshh	99	28	of	of	IN
cord-256201-vjzfzshh	99	29	(	(	-LRB-
cord-256201-vjzfzshh	99	30	1.58	1.58	CD
cord-256201-vjzfzshh	99	31	6	6	CD
cord-256201-vjzfzshh	99	32	0.44	0.44	CD
cord-256201-vjzfzshh	99	33	)	)	-RRB-
cord-256201-vjzfzshh	100	1	Â	â	NN
cord-256201-vjzfzshh	101	1	10	10	CD
cord-256201-vjzfzshh	101	2	-6	-6	NNP
cord-256201-vjzfzshh	101	3	m	m	NNP
cord-256201-vjzfzshh	101	4	/	/	SYM
cord-256201-vjzfzshh	101	5	n	n	NNP
cord-256201-vjzfzshh	101	6	/	/	SYM
cord-256201-vjzfzshh	101	7	r	r	NNP
cord-256201-vjzfzshh	101	8	,	,	,
cord-256201-vjzfzshh	101	9	a	a	DT
cord-256201-vjzfzshh	101	10	value	value	NN
cord-256201-vjzfzshh	101	11	consistent	consistent	JJ
cord-256201-vjzfzshh	101	12	with	with	IN
cord-256201-vjzfzshh	101	13	previous	previous	JJ
cord-256201-vjzfzshh	101	14	studies	study	NNS
cord-256201-vjzfzshh	101	15	(	(	-LRB-
cord-256201-vjzfzshh	101	16	Raney	Raney	NNP
cord-256201-vjzfzshh	101	17	,	,	,
cord-256201-vjzfzshh	101	18	Delongchamp	Delongchamp	NNP
cord-256201-vjzfzshh	101	19	,	,	,
cord-256201-vjzfzshh	101	20	and	and	CC
cord-256201-vjzfzshh	101	21	Valentine	Valentine	NNP
cord-256201-vjzfzshh	101	22	2004	2004	CD
cord-256201-vjzfzshh	101	23	;	;	:
cord-256201-vjzfzshh	101	24	Cuevas	Cuevas	NNP
cord-256201-vjzfzshh	101	25	,	,	,
cord-256201-vjzfzshh	101	26	Duffy	Duffy	NNP
cord-256201-vjzfzshh	101	27	,	,	,
cord-256201-vjzfzshh	101	28	and	and	CC
cord-256201-vjzfzshh	101	29	Sanjuá	Sanjuá	NNP
cord-256201-vjzfzshh	101	30	n	n	NNP
cord-256201-vjzfzshh	101	31	2009	2009	CD
cord-256201-vjzfzshh	101	32	)	)	-RRB-
cord-256201-vjzfzshh	101	33	.	.	.
cord-256201-vjzfzshh	102	1	In	in	IN
cord-256201-vjzfzshh	102	2	contrast	contrast	NN
cord-256201-vjzfzshh	102	3	,	,	,
cord-256201-vjzfzshh	102	4	the	the	DT
cord-256201-vjzfzshh	102	5	rate	rate	NN
cord-256201-vjzfzshh	102	6	of	of	IN
cord-256201-vjzfzshh	102	7	the	the	DT
cord-256201-vjzfzshh	102	8	20GATC	20gatc	CD
cord-256201-vjzfzshh	102	9	virus	virus	NN
cord-256201-vjzfzshh	102	10	was	be	VBD
cord-256201-vjzfzshh	102	11	(	(	-LRB-
cord-256201-vjzfzshh	102	12	2.06	2.06	CD
cord-256201-vjzfzshh	102	13	6	6	CD
cord-256201-vjzfzshh	102	14	0.15	0.15	CD
cord-256201-vjzfzshh	102	15	)	)	-RRB-
cord-256201-vjzfzshh	103	1	Â	â	NN
cord-256201-vjzfzshh	104	1	10	10	CD
cord-256201-vjzfzshh	104	2	-7	-7	NNP
cord-256201-vjzfzshh	104	3	m	m	NNP
cord-256201-vjzfzshh	104	4	/	/	SYM
cord-256201-vjzfzshh	104	5	n	n	NNP
cord-256201-vjzfzshh	104	6	/	/	SYM
cord-256201-vjzfzshh	104	7	r	r	NNP
cord-256201-vjzfzshh	104	8	,	,	,
cord-256201-vjzfzshh	104	9	revealing	reveal	VBG
cord-256201-vjzfzshh	104	10	a	a	DT
cord-256201-vjzfzshh	104	11	7.7-fold	7.7-fold	CD
cord-256201-vjzfzshh	104	12	reduction	reduction	NN
cord-256201-vjzfzshh	104	13	compared	compare	VBN
cord-256201-vjzfzshh	104	14	with	with	IN
cord-256201-vjzfzshh	104	15	the	the	DT
cord-256201-vjzfzshh	104	16	WT	WT	NNP
cord-256201-vjzfzshh	104	17	(	(	-LRB-
cord-256201-vjzfzshh	104	18	t	t	NN
cord-256201-vjzfzshh	104	19	-	-	HYPH
cord-256201-vjzfzshh	104	20	test	test	NN
cord-256201-vjzfzshh	104	21	:	:	:
cord-256201-vjzfzshh	105	1	P	p	NN
cord-256201-vjzfzshh	105	2	<	<	XX
cord-256201-vjzfzshh	105	3	0.001	0.001	CD
cord-256201-vjzfzshh	105	4	;	;	:
cord-256201-vjzfzshh	105	5	Table	table	NN
cord-256201-vjzfzshh	105	6	1	1	CD
cord-256201-vjzfzshh	106	1	;	;	:
cord-256201-vjzfzshh	106	2	Fig	Fig	NNP
cord-256201-vjzfzshh	106	3	.	.	.
cord-256201-vjzfzshh	106	4	2A	2a	CD
cord-256201-vjzfzshh	106	5	)	)	-RRB-
cord-256201-vjzfzshh	106	6	.	.	.
cord-256201-vjzfzshh	107	1	The	the	DT
cord-256201-vjzfzshh	107	2	estimated	estimate	VBN
cord-256201-vjzfzshh	107	3	growth	growth	NN
cord-256201-vjzfzshh	107	4	rate	rate	NN
cord-256201-vjzfzshh	107	5	was	be	VBD
cord-256201-vjzfzshh	107	6	similar	similar	JJ
cord-256201-vjzfzshh	107	7	for	for	IN
cord-256201-vjzfzshh	107	8	the	the	DT
cord-256201-vjzfzshh	107	9	WT	WT	NNP
cord-256201-vjzfzshh	108	1	(	(	-LRB-
cord-256201-vjzfzshh	108	2	r	r	NNP
cord-256201-vjzfzshh	108	3	¼	¼	NNP
cord-256201-vjzfzshh	108	4	8.11	8.11	CD
cord-256201-vjzfzshh	108	5	6	6	CD
cord-256201-vjzfzshh	108	6	0.29	0.29	CD
cord-256201-vjzfzshh	108	7	h	h	NN
cord-256201-vjzfzshh	108	8	-1	-1	NN
cord-256201-vjzfzshh	108	9	)	)	-RRB-
cord-256201-vjzfzshh	108	10	and	and	CC
cord-256201-vjzfzshh	108	11	the	the	DT
cord-256201-vjzfzshh	108	12	20GATC	20gatc	CD
cord-256201-vjzfzshh	108	13	viruses	virus	NNS
cord-256201-vjzfzshh	108	14	(	(	-LRB-
cord-256201-vjzfzshh	108	15	r	r	NNP
cord-256201-vjzfzshh	108	16	¼	¼	CD
cord-256201-vjzfzshh	108	17	8.68	8.68	CD
cord-256201-vjzfzshh	108	18	6	6	CD
cord-256201-vjzfzshh	108	19	0.29	0.29	CD
cord-256201-vjzfzshh	108	20	h	h	NN
cord-256201-vjzfzshh	108	21	-1	-1	NN
cord-256201-vjzfzshh	108	22	;	;	:
cord-256201-vjzfzshh	108	23	t	t	NN
cord-256201-vjzfzshh	108	24	-	-	HYPH
cord-256201-vjzfzshh	108	25	test	test	NN
cord-256201-vjzfzshh	108	26	:	:	:
cord-256201-vjzfzshh	109	1	P	p	NN
cord-256201-vjzfzshh	109	2	¼	¼	CD
cord-256201-vjzfzshh	109	3	0.406	0.406	CD
cord-256201-vjzfzshh	109	4	;	;	:
cord-256201-vjzfzshh	109	5	Table	table	NN
cord-256201-vjzfzshh	109	6	1	1	CD
cord-256201-vjzfzshh	109	7	;	;	:
cord-256201-vjzfzshh	109	8	Fig	Fig	NNP
cord-256201-vjzfzshh	109	9	.	.	.
cord-256201-vjzfzshh	109	10	2B	2B	NNP
cord-256201-vjzfzshh	109	11	)	)	-RRB-
cord-256201-vjzfzshh	109	12	,	,	,
cord-256201-vjzfzshh	109	13	indicating	indicate	VBG
cord-256201-vjzfzshh	109	14	that	that	IN
cord-256201-vjzfzshh	109	15	these	these	DT
cord-256201-vjzfzshh	109	16	substitutions	substitution	NNS
cord-256201-vjzfzshh	109	17	had	have	VBD
cord-256201-vjzfzshh	109	18	no	no	DT
cord-256201-vjzfzshh	109	19	significant	significant	JJ
cord-256201-vjzfzshh	109	20	impact	impact	NN
cord-256201-vjzfzshh	109	21	on	on	IN
cord-256201-vjzfzshh	109	22	short	short	JJ
cord-256201-vjzfzshh	109	23	-	-	HYPH
cord-256201-vjzfzshh	109	24	term	term	NN
cord-256201-vjzfzshh	109	25	viral	viral	JJ
cord-256201-vjzfzshh	109	26	fitness	fitness	NN
cord-256201-vjzfzshh	109	27	.	.	.
cord-256201-vjzfzshh	110	1	These	these	DT
cord-256201-vjzfzshh	110	2	findings	finding	NNS
cord-256201-vjzfzshh	110	3	confirm	confirm	VBP
cord-256201-vjzfzshh	110	4	our	-PRON-	PRP$
cord-256201-vjzfzshh	110	5	previous	previous	JJ
cord-256201-vjzfzshh	110	6	results	result	NNS
cord-256201-vjzfzshh	110	7	obtained	obtain	VBN
cord-256201-vjzfzshh	110	8	with	with	IN
cord-256201-vjzfzshh	110	9	a	a	DT
cord-256201-vjzfzshh	110	10	mutant	mutant	JJ
cord-256201-vjzfzshh	110	11	phage	phage	NN
cord-256201-vjzfzshh	110	12	carrying	carry	VBG
cord-256201-vjzfzshh	110	13	seven	seven	CD
cord-256201-vjzfzshh	110	14	GATC	GATC	NNP
cord-256201-vjzfzshh	110	15	sites	site	NNS
cord-256201-vjzfzshh	110	16	(	(	-LRB-
cord-256201-vjzfzshh	110	17	Cuevas	Cuevas	NNP
cord-256201-vjzfzshh	110	18	,	,	,
cord-256201-vjzfzshh	110	19	Pereira	Pereira	NNP
cord-256201-vjzfzshh	110	20	-	-	HYPH
cord-256201-vjzfzshh	110	21	Gomez	Gomez	NNP
cord-256201-vjzfzshh	110	22	,	,	,
cord-256201-vjzfzshh	110	23	and	and	CC
cord-256201-vjzfzshh	110	24	Sanjuá	Sanjuá	NNP
cord-256201-vjzfzshh	110	25	n	n	NNP
cord-256201-vjzfzshh	110	26	2011	2011	CD
cord-256201-vjzfzshh	110	27	)	)	-RRB-
cord-256201-vjzfzshh	110	28	.	.	.
cord-256201-vjzfzshh	111	1	Since	since	IN
cord-256201-vjzfzshh	111	2	MMR	MMR	NNP
cord-256201-vjzfzshh	111	3	relies	rely	VBZ
cord-256201-vjzfzshh	111	4	on	on	IN
cord-256201-vjzfzshh	111	5	the	the	DT
cord-256201-vjzfzshh	111	6	presence	presence	NN
cord-256201-vjzfzshh	111	7	of	of	IN
cord-256201-vjzfzshh	111	8	GATCs	GATCs	NNPS
cord-256201-vjzfzshh	111	9	in	in	IN
cord-256201-vjzfzshh	111	10	the	the	DT
cord-256201-vjzfzshh	111	11	vicinity	vicinity	NN
cord-256201-vjzfzshh	111	12	of	of	IN
cord-256201-vjzfzshh	111	13	the	the	DT
cord-256201-vjzfzshh	111	14	mismatch	mismatch	NN
cord-256201-vjzfzshh	111	15	,	,	,
cord-256201-vjzfzshh	111	16	addition	addition	NN
cord-256201-vjzfzshh	111	17	of	of	IN
cord-256201-vjzfzshh	111	18	GATCs	GATCs	NNPS
cord-256201-vjzfzshh	111	19	in	in	IN
cord-256201-vjzfzshh	111	20	this	this	DT
cord-256201-vjzfzshh	111	21	region	region	NN
cord-256201-vjzfzshh	111	22	should	should	MD
cord-256201-vjzfzshh	111	23	suffice	suffice	VB
cord-256201-vjzfzshh	111	24	to	to	TO
cord-256201-vjzfzshh	111	25	yield	yield	VB
cord-256201-vjzfzshh	111	26	similarly	similarly	RB
cord-256201-vjzfzshh	111	27	low	low	JJ
cord-256201-vjzfzshh	111	28	mutation	mutation	NN
cord-256201-vjzfzshh	111	29	rates	rate	NNS
cord-256201-vjzfzshh	111	30	.	.	.
cord-256201-vjzfzshh	112	1	On	on	IN
cord-256201-vjzfzshh	112	2	the	the	DT
cord-256201-vjzfzshh	112	3	basis	basis	NN
cord-256201-vjzfzshh	112	4	of	of	IN
cord-256201-vjzfzshh	112	5	this	this	DT
cord-256201-vjzfzshh	112	6	,	,	,
cord-256201-vjzfzshh	112	7	we	-PRON-	PRP
cord-256201-vjzfzshh	112	8	constructed	construct	VBD
cord-256201-vjzfzshh	112	9	a	a	DT
cord-256201-vjzfzshh	112	10	virus	virus	NN
cord-256201-vjzfzshh	112	11	with	with	IN
cord-256201-vjzfzshh	112	12	four	four	CD
cord-256201-vjzfzshh	112	13	GATCs	GATCs	NNPS
cord-256201-vjzfzshh	112	14	located	locate	VBN
cord-256201-vjzfzshh	112	15	between	between	IN
cord-256201-vjzfzshh	112	16	genome	genome	NN
cord-256201-vjzfzshh	112	17	positions	position	NNS
cord-256201-vjzfzshh	112	18	3671	3671	CD
cord-256201-vjzfzshh	112	19	and	and	CC
cord-256201-vjzfzshh	112	20	4151	4151	CD
cord-256201-vjzfzshh	112	21	,	,	,
cord-256201-vjzfzshh	112	22	which	which	WDT
cord-256201-vjzfzshh	112	23	were	be	VBD
cord-256201-vjzfzshh	112	24	within	within	IN
cord-256201-vjzfzshh	112	25	0.5	0.5	CD
cord-256201-vjzfzshh	112	26	kb	kb	CD
cord-256201-vjzfzshh	112	27	of	of	IN
cord-256201-vjzfzshh	112	28	known	know	VBN
cord-256201-vjzfzshh	112	29	groresistance	groresistance	NN
cord-256201-vjzfzshh	112	30	mutations	mutation	NNS
cord-256201-vjzfzshh	112	31	(	(	-LRB-
cord-256201-vjzfzshh	112	32	Fig	Fig	NNP
cord-256201-vjzfzshh	112	33	.	.	NNP
cord-256201-vjzfzshh	112	34	1	1	CD
cord-256201-vjzfzshh	112	35	)	)	-RRB-
cord-256201-vjzfzshh	112	36	.	.	.
cord-256201-vjzfzshh	113	1	However	however	RB
cord-256201-vjzfzshh	113	2	,	,	,
cord-256201-vjzfzshh	113	3	surprisingly	surprisingly	RB
cord-256201-vjzfzshh	113	4	,	,	,
cord-256201-vjzfzshh	113	5	the	the	DT
cord-256201-vjzfzshh	113	6	mutation	mutation	NN
cord-256201-vjzfzshh	113	7	rate	rate	NN
cord-256201-vjzfzshh	113	8	of	of	IN
cord-256201-vjzfzshh	113	9	this	this	DT
cord-256201-vjzfzshh	113	10	four	four	CD
cord-256201-vjzfzshh	113	11	GATC	GATC	NNP
cord-256201-vjzfzshh	113	12	virus	virus	NN
cord-256201-vjzfzshh	113	13	was	be	VBD
cord-256201-vjzfzshh	113	14	significantly	significantly	RB
cord-256201-vjzfzshh	113	15	higher	high	JJR
cord-256201-vjzfzshh	113	16	than	than	IN
cord-256201-vjzfzshh	113	17	that	that	DT
cord-256201-vjzfzshh	113	18	of	of	IN
cord-256201-vjzfzshh	113	19	the	the	DT
cord-256201-vjzfzshh	113	20	20GATC	20gatc	CD
cord-256201-vjzfzshh	113	21	virus	virus	NN
cord-256201-vjzfzshh	113	22	(	(	-LRB-
cord-256201-vjzfzshh	113	23	t	t	NN
cord-256201-vjzfzshh	113	24	-	-	HYPH
cord-256201-vjzfzshh	113	25	test	test	NN
cord-256201-vjzfzshh	113	26	:	:	:
cord-256201-vjzfzshh	113	27	P	p	NN
cord-256201-vjzfzshh	113	28	¼	¼	CD
cord-256201-vjzfzshh	113	29	0.001	0.001	CD
cord-256201-vjzfzshh	113	30	)	)	-RRB-
cord-256201-vjzfzshh	113	31	and	and	CC
cord-256201-vjzfzshh	113	32	similar	similar	JJ
cord-256201-vjzfzshh	113	33	to	to	IN
cord-256201-vjzfzshh	113	34	the	the	DT
cord-256201-vjzfzshh	113	35	WT	WT	NNP
cord-256201-vjzfzshh	113	36	rate	rate	NN
cord-256201-vjzfzshh	113	37	(	(	-LRB-
cord-256201-vjzfzshh	113	38	P	p	NN
cord-256201-vjzfzshh	113	39	¼	¼	CD
cord-256201-vjzfzshh	113	40	0.832	0.832	CD
cord-256201-vjzfzshh	113	41	)	)	-RRB-
cord-256201-vjzfzshh	113	42	.	.	.
cord-256201-vjzfzshh	114	1	In	in	IN
cord-256201-vjzfzshh	114	2	light	light	NN
cord-256201-vjzfzshh	114	3	of	of	IN
cord-256201-vjzfzshh	114	4	this	this	DT
cord-256201-vjzfzshh	114	5	result	result	NN
cord-256201-vjzfzshh	114	6	and	and	CC
cord-256201-vjzfzshh	114	7	since	since	IN
cord-256201-vjzfzshh	114	8	Dam	dam	JJ
cord-256201-vjzfzshh	114	9	methylation	methylation	NN
cord-256201-vjzfzshh	114	10	of	of	IN
cord-256201-vjzfzshh	114	11	GATC	GATC	NNP
cord-256201-vjzfzshh	114	12	adenosines	adenosines	NNP
cord-256201-vjzfzshh	114	13	is	be	VBZ
cord-256201-vjzfzshh	114	14	required	require	VBN
cord-256201-vjzfzshh	114	15	for	for	IN
cord-256201-vjzfzshh	114	16	MMR	MMR	NNP
cord-256201-vjzfzshh	114	17	,	,	,
cord-256201-vjzfzshh	114	18	we	-PRON-	PRP
cord-256201-vjzfzshh	114	19	sought	seek	VBD
cord-256201-vjzfzshh	114	20	to	to	TO
cord-256201-vjzfzshh	114	21	determine	determine	VB
cord-256201-vjzfzshh	114	22	the	the	DT
cord-256201-vjzfzshh	114	23	methylation	methylation	NN
cord-256201-vjzfzshh	114	24	status	status	NN
cord-256201-vjzfzshh	114	25	of	of	IN
cord-256201-vjzfzshh	114	26	the	the	DT
cord-256201-vjzfzshh	114	27	4GATC	4gatc	CD
cord-256201-vjzfzshh	114	28	/X174	/x174	SYM
cord-256201-vjzfzshh	114	29	DNA	dna	NN
cord-256201-vjzfzshh	114	30	.	.	.
cord-256201-vjzfzshh	115	1	To	to	TO
cord-256201-vjzfzshh	115	2	do	do	VB
cord-256201-vjzfzshh	115	3	so	so	RB
cord-256201-vjzfzshh	115	4	,	,	,
cord-256201-vjzfzshh	115	5	we	-PRON-	PRP
cord-256201-vjzfzshh	115	6	purified	purify	VBD
cord-256201-vjzfzshh	115	7	the	the	DT
cord-256201-vjzfzshh	115	8	dsDNA	dsdna	RB
cord-256201-vjzfzshh	115	9	replicative	replicative	JJ
cord-256201-vjzfzshh	115	10	form	form	NN
cord-256201-vjzfzshh	115	11	,	,	,
cord-256201-vjzfzshh	115	12	linearized	linearize	VBN
cord-256201-vjzfzshh	115	13	it	-PRON-	PRP
cord-256201-vjzfzshh	115	14	,	,	,
cord-256201-vjzfzshh	115	15	and	and	CC
cord-256201-vjzfzshh	115	16	treated	treat	VBD
cord-256201-vjzfzshh	115	17	it	-PRON-	PRP
cord-256201-vjzfzshh	115	18	with	with	IN
cord-256201-vjzfzshh	115	19	the	the	DT
cord-256201-vjzfzshh	115	20	DpnI	DpnI	NNP
cord-256201-vjzfzshh	115	21	restriction	restriction	NN
cord-256201-vjzfzshh	115	22	endonuclease	endonuclease	NN
cord-256201-vjzfzshh	115	23	,	,	,
cord-256201-vjzfzshh	115	24	which	which	WDT
cord-256201-vjzfzshh	115	25	selectively	selectively	RB
cord-256201-vjzfzshh	115	26	digests	digest	VBZ
cord-256201-vjzfzshh	115	27	methylated	methylate	VBN
cord-256201-vjzfzshh	115	28	and	and	CC
cord-256201-vjzfzshh	115	29	hemi	hemi	NN
cord-256201-vjzfzshh	115	30	-	-	HYPH
cord-256201-vjzfzshh	115	31	methylated	methylate	VBN
cord-256201-vjzfzshh	115	32	GATCs	GATCs	NNPS
cord-256201-vjzfzshh	115	33	.	.	.
cord-256201-vjzfzshh	116	1	Although	although	IN
cord-256201-vjzfzshh	116	2	DpnI	DpnI	NNP
cord-256201-vjzfzshh	116	3	produced	produce	VBD
cord-256201-vjzfzshh	116	4	restriction	restriction	NN
cord-256201-vjzfzshh	116	5	bands	band	NNS
cord-256201-vjzfzshh	116	6	of	of	IN
cord-256201-vjzfzshh	116	7	the	the	DT
cord-256201-vjzfzshh	116	8	expected	expect	VBN
cord-256201-vjzfzshh	116	9	size	size	NN
cord-256201-vjzfzshh	116	10	,	,	,
cord-256201-vjzfzshh	116	11	digestion	digestion	NN
cord-256201-vjzfzshh	116	12	was	be	VBD
cord-256201-vjzfzshh	116	13	only	only	RB
cord-256201-vjzfzshh	116	14	partial	partial	JJ
cord-256201-vjzfzshh	116	15	(	(	-LRB-
cord-256201-vjzfzshh	116	16	Fig	fig	NN
cord-256201-vjzfzshh	116	17	.	.	.
cord-256201-vjzfzshh	116	18	3	3	CD
cord-256201-vjzfzshh	116	19	)	)	-RRB-
cord-256201-vjzfzshh	116	20	.	.	.
cord-256201-vjzfzshh	117	1	To	to	TO
cord-256201-vjzfzshh	117	2	test	test	VB
cord-256201-vjzfzshh	117	3	whether	whether	IN
cord-256201-vjzfzshh	117	4	this	this	DT
cord-256201-vjzfzshh	117	5	could	could	MD
cord-256201-vjzfzshh	117	6	be	be	VB
cord-256201-vjzfzshh	117	7	explained	explain	VBN
cord-256201-vjzfzshh	117	8	by	by	IN
cord-256201-vjzfzshh	117	9	incomplete	incomplete	JJ
cord-256201-vjzfzshh	117	10	DNA	dna	NN
cord-256201-vjzfzshh	117	11	methylation	methylation	NN
cord-256201-vjzfzshh	117	12	,	,	,
cord-256201-vjzfzshh	117	13	we	-PRON-	PRP
cord-256201-vjzfzshh	117	14	performed	perform	VBD
cord-256201-vjzfzshh	117	15	the	the	DT
cord-256201-vjzfzshh	117	16	same	same	JJ
cord-256201-vjzfzshh	117	17	restriction	restriction	NN
cord-256201-vjzfzshh	117	18	analysis	analysis	NN
cord-256201-vjzfzshh	117	19	using	use	VBG
cord-256201-vjzfzshh	117	20	MboI	MboI	NNP
cord-256201-vjzfzshh	117	21	,	,	,
cord-256201-vjzfzshh	117	22	which	which	WDT
cord-256201-vjzfzshh	117	23	also	also	RB
cord-256201-vjzfzshh	117	24	recognizes	recognize	VBZ
cord-256201-vjzfzshh	117	25	GATC	GATC	NNP
cord-256201-vjzfzshh	117	26	sites	site	NNS
cord-256201-vjzfzshh	117	27	but	but	CC
cord-256201-vjzfzshh	117	28	digests	digest	VBZ
cord-256201-vjzfzshh	117	29	them	-PRON-	PRP
cord-256201-vjzfzshh	117	30	only	only	RB
cord-256201-vjzfzshh	117	31	in	in	IN
cord-256201-vjzfzshh	117	32	their	-PRON-	PRP$
cord-256201-vjzfzshh	117	33	non	non	JJ
cord-256201-vjzfzshh	117	34	-	-	JJ
cord-256201-vjzfzshh	117	35	methylated	methylated	JJ
cord-256201-vjzfzshh	117	36	form	form	NN
cord-256201-vjzfzshh	117	37	.	.	.
cord-256201-vjzfzshh	118	1	MboI	MboI	NNP
cord-256201-vjzfzshh	118	2	also	also	RB
cord-256201-vjzfzshh	118	3	produced	produce	VBD
cord-256201-vjzfzshh	118	4	restriction	restriction	NN
cord-256201-vjzfzshh	118	5	bands	band	NNS
cord-256201-vjzfzshh	118	6	,	,	,
cord-256201-vjzfzshh	118	7	thus	thus	RB
cord-256201-vjzfzshh	118	8	confirming	confirm	VBG
cord-256201-vjzfzshh	118	9	that	that	IN
cord-256201-vjzfzshh	118	10	a	a	DT
cord-256201-vjzfzshh	118	11	fraction	fraction	NN
cord-256201-vjzfzshh	118	12	of	of	IN
cord-256201-vjzfzshh	118	13	the	the	DT
cord-256201-vjzfzshh	118	14	phage	phage	NN
cord-256201-vjzfzshh	118	15	dsDNA	dsdna	RB
cord-256201-vjzfzshh	118	16	was	be	VBD
cord-256201-vjzfzshh	118	17	not	not	RB
cord-256201-vjzfzshh	118	18	methylated	methylate	VBN
cord-256201-vjzfzshh	118	19	.	.	.
cord-256201-vjzfzshh	119	1	Image	image	NN
cord-256201-vjzfzshh	119	2	analysis	analysis	NN
cord-256201-vjzfzshh	119	3	indicated	indicate	VBD
cord-256201-vjzfzshh	119	4	that	that	IN
cord-256201-vjzfzshh	119	5	82	82	CD
cord-256201-vjzfzshh	119	6	per	per	NN
cord-256201-vjzfzshh	119	7	cent	cent	NN
cord-256201-vjzfzshh	119	8	of	of	IN
cord-256201-vjzfzshh	119	9	DNA	DNA	NNP
cord-256201-vjzfzshh	119	10	was	be	VBD
cord-256201-vjzfzshh	119	11	digested	digest	VBN
cord-256201-vjzfzshh	119	12	by	by	IN
cord-256201-vjzfzshh	119	13	MboI	MboI	NNP
cord-256201-vjzfzshh	119	14	and	and	CC
cord-256201-vjzfzshh	119	15	thus	thus	RB
cord-256201-vjzfzshh	119	16	lacked	lack	VBD
cord-256201-vjzfzshh	119	17	at	at	IN
cord-256201-vjzfzshh	119	18	least	least	RBS
cord-256201-vjzfzshh	119	19	one	one	CD
cord-256201-vjzfzshh	119	20	of	of	IN
cord-256201-vjzfzshh	119	21	the	the	DT
cord-256201-vjzfzshh	119	22	four	four	CD
cord-256201-vjzfzshh	119	23	possible	possible	JJ
cord-256201-vjzfzshh	119	24	methyl	methyl	NN
cord-256201-vjzfzshh	119	25	groups	group	NNS
cord-256201-vjzfzshh	119	26	,	,	,
cord-256201-vjzfzshh	119	27	whereas	whereas	IN
cord-256201-vjzfzshh	119	28	12	12	CD
cord-256201-vjzfzshh	119	29	per	per	NN
cord-256201-vjzfzshh	119	30	cent	cent	NN
cord-256201-vjzfzshh	119	31	was	be	VBD
cord-256201-vjzfzshh	119	32	undigested	undigested	JJ
cord-256201-vjzfzshh	119	33	by	by	IN
cord-256201-vjzfzshh	119	34	DpnI	DpnI	NNP
cord-256201-vjzfzshh	119	35	,	,	,
cord-256201-vjzfzshh	119	36	thus	thus	RB
cord-256201-vjzfzshh	119	37	lacking	lack	VBG
cord-256201-vjzfzshh	119	38	all	all	DT
cord-256201-vjzfzshh	119	39	four	four	CD
cord-256201-vjzfzshh	119	40	methyl	methyl	NN
cord-256201-vjzfzshh	119	41	groups	group	NNS
cord-256201-vjzfzshh	119	42	.	.	.
cord-256201-vjzfzshh	120	1	Overall	overall	RB
cord-256201-vjzfzshh	120	2	,	,	,
cord-256201-vjzfzshh	120	3	the	the	DT
cord-256201-vjzfzshh	120	4	similar	similar	JJ
cord-256201-vjzfzshh	120	5	efficiency	efficiency	NN
cord-256201-vjzfzshh	120	6	shown	show	VBN
cord-256201-vjzfzshh	120	7	by	by	IN
cord-256201-vjzfzshh	120	8	DpnI	DpnI	NNP
cord-256201-vjzfzshh	120	9	and	and	CC
cord-256201-vjzfzshh	120	10	MboI	MboI	NNP
cord-256201-vjzfzshh	120	11	suggests	suggest	VBZ
cord-256201-vjzfzshh	120	12	that	that	IN
cord-256201-vjzfzshh	120	13	roughly	roughly	RB
cord-256201-vjzfzshh	120	14	half	half	NN
cord-256201-vjzfzshh	120	15	of	of	IN
cord-256201-vjzfzshh	120	16	GATC	GATC	NNP
cord-256201-vjzfzshh	120	17	motifs	motif	NNS
cord-256201-vjzfzshh	120	18	were	be	VBD
cord-256201-vjzfzshh	120	19	methylated	methylate	VBN
cord-256201-vjzfzshh	120	20	,	,	,
cord-256201-vjzfzshh	120	21	although	although	IN
cord-256201-vjzfzshh	120	22	more	more	JJR
cord-256201-vjzfzshh	120	23	detailed	detailed	JJ
cord-256201-vjzfzshh	120	24	analyses	analysis	NNS
cord-256201-vjzfzshh	120	25	would	would	MD
cord-256201-vjzfzshh	120	26	be	be	VB
cord-256201-vjzfzshh	120	27	required	require	VBN
cord-256201-vjzfzshh	120	28	to	to	TO
cord-256201-vjzfzshh	120	29	reliably	reliably	RB
cord-256201-vjzfzshh	120	30	infer	infer	VB
cord-256201-vjzfzshh	120	31	this	this	DT
cord-256201-vjzfzshh	120	32	fraction	fraction	NN
cord-256201-vjzfzshh	120	33	.	.	.
cord-256201-vjzfzshh	121	1	We	-PRON-	PRP
cord-256201-vjzfzshh	121	2	verified	verify	VBD
cord-256201-vjzfzshh	121	3	that	that	IN
cord-256201-vjzfzshh	121	4	under	under	NN
cord-256201-vjzfzshh	121	5	-	-	HYPH
cord-256201-vjzfzshh	121	6	methylation	methylation	NN
cord-256201-vjzfzshh	121	7	was	be	VBD
cord-256201-vjzfzshh	121	8	not	not	RB
cord-256201-vjzfzshh	121	9	due	due	JJ
cord-256201-vjzfzshh	121	10	to	to	IN
cord-256201-vjzfzshh	121	11	a	a	DT
cord-256201-vjzfzshh	121	12	Dam	Dam	NNP
cord-256201-vjzfzshh	121	13	defect	defect	NN
cord-256201-vjzfzshh	121	14	in	in	IN
cord-256201-vjzfzshh	121	15	the	the	DT
cord-256201-vjzfzshh	121	16	host	host	NN
cord-256201-vjzfzshh	121	17	cell	cell	NN
cord-256201-vjzfzshh	121	18	,	,	,
cord-256201-vjzfzshh	121	19	since	since	IN
cord-256201-vjzfzshh	121	20	a	a	DT
cord-256201-vjzfzshh	121	21	standard	standard	JJ
cord-256201-vjzfzshh	121	22	plasmid	plasmid	NN
cord-256201-vjzfzshh	121	23	grown	grow	VBN
cord-256201-vjzfzshh	121	24	in	in	IN
cord-256201-vjzfzshh	121	25	the	the	DT
cord-256201-vjzfzshh	121	26	same	same	JJ
cord-256201-vjzfzshh	121	27	E.	E.	NNP
cord-256201-vjzfzshh	121	28	coli	coli	NNS
cord-256201-vjzfzshh	121	29	strain	strain	NN
cord-256201-vjzfzshh	121	30	was	be	VBD
cord-256201-vjzfzshh	121	31	fully	fully	RB
cord-256201-vjzfzshh	121	32	digested	digest	VBN
cord-256201-vjzfzshh	121	33	by	by	IN
cord-256201-vjzfzshh	121	34	DpnI	DpnI	NNP
cord-256201-vjzfzshh	121	35	and	and	CC
cord-256201-vjzfzshh	121	36	fully	fully	RB
cord-256201-vjzfzshh	121	37	resistant	resistant	JJ
cord-256201-vjzfzshh	121	38	to	to	IN
cord-256201-vjzfzshh	121	39	MboI	MboI	NNP
cord-256201-vjzfzshh	121	40	(	(	-LRB-
cord-256201-vjzfzshh	121	41	not	not	RB
cord-256201-vjzfzshh	121	42	shown	show	VBN
cord-256201-vjzfzshh	121	43	)	)	-RRB-
cord-256201-vjzfzshh	121	44	.	.	.
cord-256201-vjzfzshh	122	1	Therefore	therefore	RB
cord-256201-vjzfzshh	122	2	,	,	,
cord-256201-vjzfzshh	122	3	these	these	DT
cord-256201-vjzfzshh	122	4	results	result	NNS
cord-256201-vjzfzshh	122	5	suggest	suggest	VBP
cord-256201-vjzfzshh	122	6	that	that	IN
cord-256201-vjzfzshh	122	7	,	,	,
cord-256201-vjzfzshh	122	8	as	as	IN
cord-256201-vjzfzshh	122	9	opposed	oppose	VBN
cord-256201-vjzfzshh	122	10	to	to	TO
cord-256201-vjzfzshh	122	11	plasmid	plasmid	VB
cord-256201-vjzfzshh	122	12	or	or	CC
cord-256201-vjzfzshh	122	13	chromosomal	chromosomal	JJ
cord-256201-vjzfzshh	122	14	DNA	dna	NN
cord-256201-vjzfzshh	122	15	,	,	,
cord-256201-vjzfzshh	122	16	GATC	GATC	NNP
cord-256201-vjzfzshh	122	17	-	-	HYPH
cord-256201-vjzfzshh	122	18	mediated	mediate	VBN
cord-256201-vjzfzshh	122	19	MMR	MMR	NNP
cord-256201-vjzfzshh	122	20	is	be	VBZ
cord-256201-vjzfzshh	122	21	not	not	RB
cord-256201-vjzfzshh	122	22	fully	fully	RB
cord-256201-vjzfzshh	122	23	efficient	efficient	JJ
cord-256201-vjzfzshh	122	24	in	in	IN
cord-256201-vjzfzshh	122	25	/X174	/X174	.
cord-256201-vjzfzshh	122	26	because	because	IN
cord-256201-vjzfzshh	122	27	the	the	DT
cord-256201-vjzfzshh	122	28	phage	phage	NN
cord-256201-vjzfzshh	122	29	DNA	dna	NN
cord-256201-vjzfzshh	122	30	is	be	VBZ
cord-256201-vjzfzshh	122	31	under	under	RB
cord-256201-vjzfzshh	122	32	-	-	HYPH
cord-256201-vjzfzshh	122	33	methylated	methylated	JJ
cord-256201-vjzfzshh	122	34	.	.	.
cord-256201-vjzfzshh	123	1	Given	give	VBN
cord-256201-vjzfzshh	123	2	that	that	IN
cord-256201-vjzfzshh	123	3	protein	protein	NN
cord-256201-vjzfzshh	123	4	-	-	HYPH
cord-256201-vjzfzshh	123	5	coding	code	VBG
cord-256201-vjzfzshh	123	6	regions	region	NNS
cord-256201-vjzfzshh	123	7	represent	represent	VBP
cord-256201-vjzfzshh	123	8	approximately	approximately	RB
cord-256201-vjzfzshh	123	9	95	95	CD
cord-256201-vjzfzshh	123	10	per	per	IN
cord-256201-vjzfzshh	123	11	cent	cent	NN
cord-256201-vjzfzshh	123	12	of	of	IN
cord-256201-vjzfzshh	123	13	the	the	DT
cord-256201-vjzfzshh	123	14	/X174	/X174	NFP
cord-256201-vjzfzshh	123	15	genome	genome	NN
cord-256201-vjzfzshh	123	16	,	,	,
cord-256201-vjzfzshh	123	17	by	by	IN
cord-256201-vjzfzshh	123	18	chance	chance	NN
cord-256201-vjzfzshh	123	19	one	one	CD
cord-256201-vjzfzshh	123	20	in	in	IN
cord-256201-vjzfzshh	123	21	twenty	twenty	CD
cord-256201-vjzfzshh	123	22	20	20	CD
cord-256201-vjzfzshh	123	23	Figure	figure	NN
cord-256201-vjzfzshh	123	24	1	1	CD
cord-256201-vjzfzshh	123	25	.	.	.
cord-256201-vjzfzshh	124	1	/X174	/X174	.
cord-256201-vjzfzshh	125	1	genetic	genetic	JJ
cord-256201-vjzfzshh	125	2	map	map	NN
cord-256201-vjzfzshh	125	3	and	and	CC
cord-256201-vjzfzshh	125	4	location	location	NN
cord-256201-vjzfzshh	125	5	of	of	IN
cord-256201-vjzfzshh	125	6	the	the	DT
cord-256201-vjzfzshh	125	7	GATC	GATC	NNP
cord-256201-vjzfzshh	125	8	sequence	sequence	NN
cord-256201-vjzfzshh	125	9	motifs	motif	NNS
cord-256201-vjzfzshh	125	10	introduced	introduce	VBN
cord-256201-vjzfzshh	125	11	in	in	IN
cord-256201-vjzfzshh	125	12	this	this	DT
cord-256201-vjzfzshh	125	13	study	study	NN
cord-256201-vjzfzshh	125	14	.	.	.
cord-256201-vjzfzshh	126	1	Open	open	JJ
cord-256201-vjzfzshh	126	2	reading	reading	NN
cord-256201-vjzfzshh	126	3	frames	frame	NNS
cord-256201-vjzfzshh	126	4	are	be	VBP
cord-256201-vjzfzshh	126	5	represented	represent	VBN
cord-256201-vjzfzshh	126	6	by	by	IN
cord-256201-vjzfzshh	126	7	rectangles	rectangle	NNS
cord-256201-vjzfzshh	126	8	(	(	-LRB-
cord-256201-vjzfzshh	126	9	B	b	NN
cord-256201-vjzfzshh	126	10	,	,	,
cord-256201-vjzfzshh	126	11	K	K	NNP
cord-256201-vjzfzshh	126	12	,	,	,
cord-256201-vjzfzshh	126	13	and	and	CC
cord-256201-vjzfzshh	126	14	E	E	NNS
cord-256201-vjzfzshh	126	15	are	be	VBP
cord-256201-vjzfzshh	126	16	in	in	IN
cord-256201-vjzfzshh	126	17	different	different	JJ
cord-256201-vjzfzshh	126	18	reading	reading	NN
cord-256201-vjzfzshh	126	19	frames	frame	NNS
cord-256201-vjzfzshh	126	20	)	)	-RRB-
cord-256201-vjzfzshh	126	21	,	,	,
cord-256201-vjzfzshh	126	22	and	and	CC
cord-256201-vjzfzshh	126	23	gray	gray	JJ
cord-256201-vjzfzshh	126	24	bars	bar	NNS
cord-256201-vjzfzshh	126	25	indicate	indicate	VBP
cord-256201-vjzfzshh	126	26	intergenic	intergenic	JJ
cord-256201-vjzfzshh	126	27	regions	region	NNS
cord-256201-vjzfzshh	126	28	.	.	.
cord-256201-vjzfzshh	127	1	Each	each	DT
cord-256201-vjzfzshh	127	2	GATC	GATC	NNP
cord-256201-vjzfzshh	127	3	is	be	VBZ
cord-256201-vjzfzshh	127	4	represented	represent	VBN
cord-256201-vjzfzshh	127	5	by	by	IN
cord-256201-vjzfzshh	127	6	a	a	DT
cord-256201-vjzfzshh	127	7	dot	dot	NN
cord-256201-vjzfzshh	127	8	,	,	,
cord-256201-vjzfzshh	127	9	and	and	CC
cord-256201-vjzfzshh	127	10	its	-PRON-	PRP$
cord-256201-vjzfzshh	127	11	position	position	NN
cord-256201-vjzfzshh	127	12	is	be	VBZ
cord-256201-vjzfzshh	127	13	indicated	indicate	VBN
cord-256201-vjzfzshh	127	14	on	on	IN
cord-256201-vjzfzshh	127	15	top	top	NN
cord-256201-vjzfzshh	127	16	.	.	.
cord-256201-vjzfzshh	128	1	GATC	GATC	NNP
cord-256201-vjzfzshh	128	2	motifs	motif	NNS
cord-256201-vjzfzshh	128	3	that	that	WDT
cord-256201-vjzfzshh	128	4	were	be	VBD
cord-256201-vjzfzshh	128	5	synonymous	synonymous	JJ
cord-256201-vjzfzshh	128	6	in	in	IN
cord-256201-vjzfzshh	128	7	all	all	DT
cord-256201-vjzfzshh	128	8	reading	reading	NN
cord-256201-vjzfzshh	128	9	frames	frame	NNS
cord-256201-vjzfzshh	128	10	are	be	VBP
cord-256201-vjzfzshh	128	11	indicated	indicate	VBN
cord-256201-vjzfzshh	128	12	in	in	IN
cord-256201-vjzfzshh	128	13	blue	blue	JJ
cord-256201-vjzfzshh	128	14	,	,	,
cord-256201-vjzfzshh	128	15	whereas	whereas	IN
cord-256201-vjzfzshh	128	16	those	those	DT
cord-256201-vjzfzshh	128	17	producing	produce	VBG
cord-256201-vjzfzshh	128	18	amino	amino	NN
cord-256201-vjzfzshh	128	19	acid	acid	NN
cord-256201-vjzfzshh	128	20	replacements	replacement	NNS
cord-256201-vjzfzshh	128	21	in	in	IN
cord-256201-vjzfzshh	128	22	at	at	RB
cord-256201-vjzfzshh	128	23	least	least	RBS
cord-256201-vjzfzshh	128	24	one	one	CD
cord-256201-vjzfzshh	128	25	frame	frame	NN
cord-256201-vjzfzshh	128	26	are	be	VBP
cord-256201-vjzfzshh	128	27	shown	show	VBN
cord-256201-vjzfzshh	128	28	in	in	IN
cord-256201-vjzfzshh	128	29	green	green	JJ
cord-256201-vjzfzshh	129	1	(	(	-LRB-
cord-256201-vjzfzshh	129	2	A74C	A74C	NNP
cord-256201-vjzfzshh	129	3	produces	produce	VBZ
cord-256201-vjzfzshh	129	4	a	a	DT
cord-256201-vjzfzshh	129	5	K494Q	K494Q	NNP
cord-256201-vjzfzshh	129	6	replacement	replacement	NN
cord-256201-vjzfzshh	129	7	in	in	IN
cord-256201-vjzfzshh	129	8	gene	gene	NN
cord-256201-vjzfzshh	129	9	A	A	NNP
cord-256201-vjzfzshh	129	10	and	and	CC
cord-256201-vjzfzshh	129	11	is	be	VBZ
cord-256201-vjzfzshh	129	12	synonymous	synonymous	JJ
cord-256201-vjzfzshh	129	13	in	in	IN
cord-256201-vjzfzshh	129	14	gene	gene	NN
cord-256201-vjzfzshh	129	15	K	k	NN
cord-256201-vjzfzshh	129	16	;	;	:
cord-256201-vjzfzshh	129	17	T5374	T5374	NNP
cord-256201-vjzfzshh	129	18	G	G	NNP
cord-256201-vjzfzshh	129	19	produces	produce	VBZ
cord-256201-vjzfzshh	129	20	a	a	DT
cord-256201-vjzfzshh	129	21	V465	v465	JJ
cord-256201-vjzfzshh	129	22	G	g	NN
cord-256201-vjzfzshh	129	23	replacement	replacement	NN
cord-256201-vjzfzshh	129	24	in	in	IN
cord-256201-vjzfzshh	129	25	gene	gene	NN
cord-256201-vjzfzshh	129	26	A	A	NNP
cord-256201-vjzfzshh	129	27	and	and	CC
cord-256201-vjzfzshh	129	28	is	be	VBZ
cord-256201-vjzfzshh	129	29	synonymous	synonymous	JJ
cord-256201-vjzfzshh	129	30	in	in	IN
cord-256201-vjzfzshh	129	31	gene	gene	NN
cord-256201-vjzfzshh	129	32	B	b	NN
cord-256201-vjzfzshh	129	33	)	)	-RRB-
cord-256201-vjzfzshh	129	34	.	.	.
cord-256201-vjzfzshh	130	1	Mutations	mutation	NNS
cord-256201-vjzfzshh	130	2	falling	fall	VBG
cord-256201-vjzfzshh	130	3	at	at	IN
cord-256201-vjzfzshh	130	4	intergenic	intergenic	JJ
cord-256201-vjzfzshh	130	5	regions	region	NNS
cord-256201-vjzfzshh	130	6	are	be	VBP
cord-256201-vjzfzshh	130	7	shown	show	VBN
cord-256201-vjzfzshh	130	8	in	in	IN
cord-256201-vjzfzshh	130	9	red	red	NN
cord-256201-vjzfzshh	130	10	.	.	.
cord-256201-vjzfzshh	131	1	The	the	DT
cord-256201-vjzfzshh	131	2	phage	phage	NN
cord-256201-vjzfzshh	131	3	has	have	VBZ
cord-256201-vjzfzshh	131	4	circular	circular	JJ
cord-256201-vjzfzshh	131	5	DNA	dna	NN
cord-256201-vjzfzshh	131	6	but	but	CC
cord-256201-vjzfzshh	131	7	is	be	VBZ
cord-256201-vjzfzshh	131	8	represented	represent	VBN
cord-256201-vjzfzshh	131	9	linearly	linearly	RB
cord-256201-vjzfzshh	131	10	for	for	IN
cord-256201-vjzfzshh	131	11	convenience	convenience	NN
cord-256201-vjzfzshh	131	12	,	,	,
cord-256201-vjzfzshh	131	13	where	where	WRB
cord-256201-vjzfzshh	131	14	by	by	IN
cord-256201-vjzfzshh	131	15	convention	convention	NN
cord-256201-vjzfzshh	131	16	the	the	DT
cord-256201-vjzfzshh	131	17	first	first	JJ
cord-256201-vjzfzshh	131	18	position	position	NN
cord-256201-vjzfzshh	131	19	corresponds	correspond	VBZ
cord-256201-vjzfzshh	131	20	to	to	IN
cord-256201-vjzfzshh	131	21	the	the	DT
cord-256201-vjzfzshh	131	22	last	last	JJ
cord-256201-vjzfzshh	131	23	nucleotide	nucleotide	NN
cord-256201-vjzfzshh	131	24	of	of	IN
cord-256201-vjzfzshh	131	25	the	the	DT
cord-256201-vjzfzshh	131	26	unique	unique	JJ
cord-256201-vjzfzshh	131	27	PstI	PstI	NNP
cord-256201-vjzfzshh	131	28	site	site	NN
cord-256201-vjzfzshh	131	29	.	.	.
cord-256201-vjzfzshh	131	30	 	 	_SP
cord-256201-vjzfzshh	132	1	where	where	WRB
cord-256201-vjzfzshh	132	2	T	T	NNP
cord-256201-vjzfzshh	132	3	¼	¼	NNP
cord-256201-vjzfzshh	132	4	7	7	CD
cord-256201-vjzfzshh	132	5	is	be	VBZ
cord-256201-vjzfzshh	132	6	the	the	DT
cord-256201-vjzfzshh	132	7	number	number	NN
cord-256201-vjzfzshh	132	8	of	of	IN
cord-256201-vjzfzshh	132	9	substitutions	substitution	NNS
cord-256201-vjzfzshh	132	10	leading	lead	VBG
cord-256201-vjzfzshh	132	11	to	to	IN
cord-256201-vjzfzshh	132	12	gro87	gro87	CD
cord-256201-vjzfzshh	132	13	resistance	resistance	NN
cord-256201-vjzfzshh	132	14	.	.	.
cord-256201-vjzfzshh	133	1	g	g	NNP
cord-256201-vjzfzshh	133	2	r	r	NN
cord-256201-vjzfzshh	133	3	¼	¼	NNP
cord-256201-vjzfzshh	134	1	lnðN1	lnðN1	.
cord-256201-vjzfzshh	135	1	=	=	NFP
cord-256201-vjzfzshh	136	1	N0Þ	n0þ	JJ
cord-256201-vjzfzshh	137	1	=	=	SYM
cord-256201-vjzfzshh	137	2	t	t	NNP
cord-256201-vjzfzshh	137	3	,	,	,
cord-256201-vjzfzshh	137	4	where	where	WRB
cord-256201-vjzfzshh	137	5	t	t	NNP
cord-256201-vjzfzshh	137	6	is	be	VBZ
cord-256201-vjzfzshh	137	7	the	the	DT
cord-256201-vjzfzshh	137	8	incubation	incubation	NN
cord-256201-vjzfzshh	137	9	time	time	NN
cord-256201-vjzfzshh	137	10	in	in	IN
cord-256201-vjzfzshh	137	11	hours	hour	NNS
cord-256201-vjzfzshh	137	12	.	.	.
cord-256201-vjzfzshh	138	1	Table	table	NN
cord-256201-vjzfzshh	138	2	1	1	CD
cord-256201-vjzfzshh	138	3	for	for	IN
cord-256201-vjzfzshh	138	4	details	detail	NNS
cord-256201-vjzfzshh	138	5	.	.	.
cord-256201-vjzfzshh	139	1	GATC	GATC	NNP
cord-256201-vjzfzshh	139	2	sites	site	NNS
cord-256201-vjzfzshh	139	3	should	should	MD
cord-256201-vjzfzshh	139	4	fall	fall	VB
cord-256201-vjzfzshh	139	5	at	at	IN
cord-256201-vjzfzshh	139	6	intergenic	intergenic	JJ
cord-256201-vjzfzshh	139	7	regions	region	NNS
cord-256201-vjzfzshh	139	8	.	.	.
cord-256201-vjzfzshh	140	1	To	to	TO
cord-256201-vjzfzshh	140	2	test	test	VB
cord-256201-vjzfzshh	140	3	how	how	WRB
cord-256201-vjzfzshh	140	4	GATC	GATC	NNP
cord-256201-vjzfzshh	140	5	location	location	NN
cord-256201-vjzfzshh	140	6	may	may	MD
cord-256201-vjzfzshh	140	7	influence	influence	VB
cord-256201-vjzfzshh	140	8	MMR	MMR	NNP
cord-256201-vjzfzshh	140	9	and	and	CC
cord-256201-vjzfzshh	140	10	the	the	DT
cord-256201-vjzfzshh	140	11	phage	phage	NN
cord-256201-vjzfzshh	140	12	mutation	mutation	NN
cord-256201-vjzfzshh	140	13	rate	rate	NN
cord-256201-vjzfzshh	140	14	,	,	,
cord-256201-vjzfzshh	140	15	we	-PRON-	PRP
cord-256201-vjzfzshh	140	16	created	create	VBD
cord-256201-vjzfzshh	140	17	another	another	DT
cord-256201-vjzfzshh	140	18	mutant	mutant	NN
cord-256201-vjzfzshh	140	19	(	(	-LRB-
cord-256201-vjzfzshh	140	20	4iGATC	4igatc	CD
cord-256201-vjzfzshh	140	21	)	)	-RRB-
cord-256201-vjzfzshh	140	22	in	in	IN
cord-256201-vjzfzshh	140	23	which	which	WDT
cord-256201-vjzfzshh	140	24	one	one	CD
cord-256201-vjzfzshh	140	25	of	of	IN
cord-256201-vjzfzshh	140	26	the	the	DT
cord-256201-vjzfzshh	140	27	four	four	CD
cord-256201-vjzfzshh	140	28	synonymous	synonymous	JJ
cord-256201-vjzfzshh	140	29	substitutions	substitution	NNS
cord-256201-vjzfzshh	140	30	of	of	IN
cord-256201-vjzfzshh	140	31	the	the	DT
cord-256201-vjzfzshh	140	32	above	above	JJ
cord-256201-vjzfzshh	140	33	4GATC	4gatc	CD
cord-256201-vjzfzshh	140	34	virus	virus	NN
cord-256201-vjzfzshh	140	35	was	be	VBD
cord-256201-vjzfzshh	140	36	replaced	replace	VBN
cord-256201-vjzfzshh	140	37	by	by	IN
cord-256201-vjzfzshh	140	38	substitution	substitution	NN
cord-256201-vjzfzshh	140	39	A3963	A3963	NNP
cord-256201-vjzfzshh	140	40	G	g	NN
cord-256201-vjzfzshh	140	41	,	,	,
cord-256201-vjzfzshh	140	42	which	which	WDT
cord-256201-vjzfzshh	140	43	was	be	VBD
cord-256201-vjzfzshh	140	44	located	locate	VBN
cord-256201-vjzfzshh	140	45	in	in	IN
cord-256201-vjzfzshh	140	46	the	the	DT
cord-256201-vjzfzshh	140	47	spacer	spacer	NN
cord-256201-vjzfzshh	140	48	region	region	NN
cord-256201-vjzfzshh	140	49	between	between	IN
cord-256201-vjzfzshh	140	50	genes	gene	NNS
cord-256201-vjzfzshh	140	51	H	H	NNP
cord-256201-vjzfzshh	140	52	and	and	CC
cord-256201-vjzfzshh	140	53	A.	a.	NN
cord-256201-vjzfzshh	141	1	The	the	DT
cord-256201-vjzfzshh	141	2	mutation	mutation	NN
cord-256201-vjzfzshh	141	3	rate	rate	NN
cord-256201-vjzfzshh	141	4	of	of	IN
cord-256201-vjzfzshh	141	5	the	the	DT
cord-256201-vjzfzshh	141	6	4iGATC	4igatc	CD
cord-256201-vjzfzshh	141	7	was	be	VBD
cord-256201-vjzfzshh	141	8	(	(	-LRB-
cord-256201-vjzfzshh	141	9	2.27	2.27	CD
cord-256201-vjzfzshh	141	10	6	6	CD
cord-256201-vjzfzshh	141	11	1.04	1.04	CD
cord-256201-vjzfzshh	141	12	)	)	-RRB-
cord-256201-vjzfzshh	142	1	Â	â	NN
cord-256201-vjzfzshh	143	1	10	10	CD
cord-256201-vjzfzshh	143	2	-8	-8	NNPS
cord-256201-vjzfzshh	143	3	m	m	NNP
cord-256201-vjzfzshh	143	4	/	/	SYM
cord-256201-vjzfzshh	143	5	n	n	NNP
cord-256201-vjzfzshh	143	6	/	/	SYM
cord-256201-vjzfzshh	143	7	r	r	NNP
cord-256201-vjzfzshh	143	8	,	,	,
cord-256201-vjzfzshh	143	9	which	which	WDT
cord-256201-vjzfzshh	143	10	represents	represent	VBZ
cord-256201-vjzfzshh	143	11	a	a	DT
cord-256201-vjzfzshh	143	12	fiftyfold	fiftyfold	JJ
cord-256201-vjzfzshh	143	13	reduction	reduction	NN
cord-256201-vjzfzshh	143	14	compared	compare	VBN
cord-256201-vjzfzshh	143	15	with	with	IN
cord-256201-vjzfzshh	143	16	the	the	DT
cord-256201-vjzfzshh	143	17	WT	WT	NNP
cord-256201-vjzfzshh	143	18	(	(	-LRB-
cord-256201-vjzfzshh	143	19	t	t	NN
cord-256201-vjzfzshh	143	20	-	-	HYPH
cord-256201-vjzfzshh	143	21	test	test	NN
cord-256201-vjzfzshh	143	22	:	:	:
cord-256201-vjzfzshh	144	1	P	p	NN
cord-256201-vjzfzshh	144	2	<	<	XX
cord-256201-vjzfzshh	144	3	0.001	0.001	CD
cord-256201-vjzfzshh	144	4	;	;	:
cord-256201-vjzfzshh	144	5	Table	table	NN
cord-256201-vjzfzshh	144	6	1	1	CD
cord-256201-vjzfzshh	144	7	)	)	-RRB-
cord-256201-vjzfzshh	144	8	.	.	.
cord-256201-vjzfzshh	145	1	Therefore	therefore	RB
cord-256201-vjzfzshh	145	2	,	,	,
cord-256201-vjzfzshh	145	3	addition	addition	NN
cord-256201-vjzfzshh	145	4	of	of	IN
cord-256201-vjzfzshh	145	5	this	this	DT
cord-256201-vjzfzshh	145	6	single	single	JJ
cord-256201-vjzfzshh	145	7	intergenic	intergenic	JJ
cord-256201-vjzfzshh	145	8	substitution	substitution	NN
cord-256201-vjzfzshh	145	9	had	have	VBD
cord-256201-vjzfzshh	145	10	a	a	DT
cord-256201-vjzfzshh	145	11	dramatic	dramatic	JJ
cord-256201-vjzfzshh	145	12	effect	effect	NN
cord-256201-vjzfzshh	145	13	on	on	IN
cord-256201-vjzfzshh	145	14	the	the	DT
cord-256201-vjzfzshh	145	15	viral	viral	JJ
cord-256201-vjzfzshh	145	16	mutation	mutation	NN
cord-256201-vjzfzshh	145	17	rate	rate	NN
cord-256201-vjzfzshh	145	18	,	,	,
cord-256201-vjzfzshh	145	19	compared	compare	VBN
cord-256201-vjzfzshh	145	20	with	with	IN
cord-256201-vjzfzshh	145	21	the	the	DT
cord-256201-vjzfzshh	145	22	4GATC	4gatc	CD
cord-256201-vjzfzshh	145	23	virus	virus	NN
cord-256201-vjzfzshh	145	24	.	.	.
cord-256201-vjzfzshh	146	1	To	to	TO
cord-256201-vjzfzshh	146	2	further	further	RB
cord-256201-vjzfzshh	146	3	test	test	VB
cord-256201-vjzfzshh	146	4	the	the	DT
cord-256201-vjzfzshh	146	5	effect	effect	NN
cord-256201-vjzfzshh	146	6	of	of	IN
cord-256201-vjzfzshh	146	7	intergenic	intergenic	JJ
cord-256201-vjzfzshh	146	8	GATCs	GATCs	NNP
cord-256201-vjzfzshh	146	9	on	on	IN
cord-256201-vjzfzshh	146	10	MMR	MMR	NNP
cord-256201-vjzfzshh	146	11	,	,	,
cord-256201-vjzfzshh	146	12	we	-PRON-	PRP
cord-256201-vjzfzshh	146	13	first	first	RB
cord-256201-vjzfzshh	146	14	created	create	VBD
cord-256201-vjzfzshh	146	15	the	the	DT
cord-256201-vjzfzshh	146	16	single	single	JJ
cord-256201-vjzfzshh	146	17	mutant	mutant	JJ
cord-256201-vjzfzshh	146	18	A3963	A3963	NNP
cord-256201-vjzfzshh	146	19	G	g	NN
cord-256201-vjzfzshh	146	20	,	,	,
cord-256201-vjzfzshh	146	21	which	which	WDT
cord-256201-vjzfzshh	146	22	showed	show	VBD
cord-256201-vjzfzshh	146	23	a	a	DT
cord-256201-vjzfzshh	146	24	mutation	mutation	NN
cord-256201-vjzfzshh	146	25	rate	rate	NN
cord-256201-vjzfzshh	146	26	five	five	CD
cord-256201-vjzfzshh	146	27	times	time	NNS
cord-256201-vjzfzshh	146	28	lower	low	JJR
cord-256201-vjzfzshh	146	29	than	than	IN
cord-256201-vjzfzshh	146	30	the	the	DT
cord-256201-vjzfzshh	146	31	WT	WT	NNP
cord-256201-vjzfzshh	146	32	(	(	-LRB-
cord-256201-vjzfzshh	146	33	t	t	NN
cord-256201-vjzfzshh	146	34	-	-	HYPH
cord-256201-vjzfzshh	146	35	test	test	NN
cord-256201-vjzfzshh	146	36	:	:	:
cord-256201-vjzfzshh	146	37	P	p	NN
cord-256201-vjzfzshh	146	38	<	<	XX
cord-256201-vjzfzshh	146	39	0.001	0.001	CD
cord-256201-vjzfzshh	146	40	;	;	:
cord-256201-vjzfzshh	146	41	Table	table	NN
cord-256201-vjzfzshh	146	42	1	1	CD
cord-256201-vjzfzshh	146	43	)	)	-RRB-
cord-256201-vjzfzshh	146	44	.	.	.
cord-256201-vjzfzshh	147	1	This	this	DT
cord-256201-vjzfzshh	147	2	rate	rate	NN
cord-256201-vjzfzshh	147	3	was	be	VBD
cord-256201-vjzfzshh	147	4	significantly	significantly	RB
cord-256201-vjzfzshh	147	5	higher	high	JJR
cord-256201-vjzfzshh	147	6	than	than	IN
cord-256201-vjzfzshh	147	7	for	for	IN
cord-256201-vjzfzshh	147	8	the	the	DT
cord-256201-vjzfzshh	147	9	4iGATC	4igatc	CD
cord-256201-vjzfzshh	147	10	virus	virus	NN
cord-256201-vjzfzshh	147	11	(	(	-LRB-
cord-256201-vjzfzshh	147	12	t	t	NN
cord-256201-vjzfzshh	147	13	-	-	HYPH
cord-256201-vjzfzshh	147	14	test	test	NN
cord-256201-vjzfzshh	147	15	:	:	:
cord-256201-vjzfzshh	147	16	P	p	NN
cord-256201-vjzfzshh	147	17	¼	¼	CD
cord-256201-vjzfzshh	147	18	0.020	0.020	CD
cord-256201-vjzfzshh	147	19	)	)	-RRB-
cord-256201-vjzfzshh	147	20	,	,	,
cord-256201-vjzfzshh	147	21	showing	show	VBG
cord-256201-vjzfzshh	147	22	that	that	IN
cord-256201-vjzfzshh	147	23	the	the	DT
cord-256201-vjzfzshh	147	24	effect	effect	NN
cord-256201-vjzfzshh	147	25	of	of	IN
cord-256201-vjzfzshh	147	26	the	the	DT
cord-256201-vjzfzshh	147	27	A3963	A3963	NNP
cord-256201-vjzfzshh	147	28	G	g	NN
cord-256201-vjzfzshh	147	29	substitution	substitution	NN
cord-256201-vjzfzshh	147	30	was	be	VBD
cord-256201-vjzfzshh	147	31	enhanced	enhance	VBN
cord-256201-vjzfzshh	147	32	by	by	IN
cord-256201-vjzfzshh	147	33	the	the	DT
cord-256201-vjzfzshh	147	34	presence	presence	NN
cord-256201-vjzfzshh	147	35	of	of	IN
cord-256201-vjzfzshh	147	36	other	other	JJ
cord-256201-vjzfzshh	147	37	,	,	,
cord-256201-vjzfzshh	147	38	neighboring	neighbor	VBG
cord-256201-vjzfzshh	147	39	GATC	GATC	NNP
cord-256201-vjzfzshh	147	40	sites	site	NNS
cord-256201-vjzfzshh	147	41	,	,	,
cord-256201-vjzfzshh	147	42	consistent	consistent	JJ
cord-256201-vjzfzshh	147	43	with	with	IN
cord-256201-vjzfzshh	147	44	the	the	DT
cord-256201-vjzfzshh	147	45	lack	lack	NN
cord-256201-vjzfzshh	147	46	of	of	IN
cord-256201-vjzfzshh	147	47	full	full	JJ
cord-256201-vjzfzshh	147	48	methylation	methylation	NN
cord-256201-vjzfzshh	147	49	shown	show	VBN
cord-256201-vjzfzshh	147	50	above	above	RB
cord-256201-vjzfzshh	147	51	.	.	.
cord-256201-vjzfzshh	148	1	Then	then	RB
cord-256201-vjzfzshh	148	2	,	,	,
cord-256201-vjzfzshh	148	3	we	-PRON-	PRP
cord-256201-vjzfzshh	148	4	constructed	construct	VBD
cord-256201-vjzfzshh	148	5	two	two	CD
cord-256201-vjzfzshh	148	6	additional	additional	JJ
cord-256201-vjzfzshh	148	7	intergenic	intergenic	JJ
cord-256201-vjzfzshh	148	8	single	single	JJ
cord-256201-vjzfzshh	148	9	-	-	HYPH
cord-256201-vjzfzshh	148	10	GATC	gatc	NN
cord-256201-vjzfzshh	148	11	viruses	virus	NNS
cord-256201-vjzfzshh	148	12	located	locate	VBN
cord-256201-vjzfzshh	148	13	in	in	IN
cord-256201-vjzfzshh	148	14	the	the	DT
cord-256201-vjzfzshh	148	15	region	region	NN
cord-256201-vjzfzshh	148	16	between	between	IN
cord-256201-vjzfzshh	148	17	the	the	DT
cord-256201-vjzfzshh	148	18	H	H	NNP
cord-256201-vjzfzshh	148	19	and	and	CC
cord-256201-vjzfzshh	148	20	A	a	DT
cord-256201-vjzfzshh	148	21	genes	gene	NNS
cord-256201-vjzfzshh	148	22	by	by	IN
cord-256201-vjzfzshh	148	23	introducing	introduce	VBG
cord-256201-vjzfzshh	148	24	the	the	DT
cord-256201-vjzfzshh	148	25	appropriate	appropriate	JJ
cord-256201-vjzfzshh	148	26	nucleotide	nucleotide	JJ
cord-256201-vjzfzshh	148	27	substitutions	substitution	NNS
cord-256201-vjzfzshh	148	28	(	(	-LRB-
cord-256201-vjzfzshh	148	29	Fig	Fig	NNP
cord-256201-vjzfzshh	148	30	.	.	NNP
cord-256201-vjzfzshh	148	31	1	1	CD
cord-256201-vjzfzshh	148	32	)	)	-RRB-
cord-256201-vjzfzshh	148	33	.	.	.
cord-256201-vjzfzshh	149	1	The	the	DT
cord-256201-vjzfzshh	149	2	mutation	mutation	NN
cord-256201-vjzfzshh	149	3	rate	rate	NN
cord-256201-vjzfzshh	149	4	of	of	IN
cord-256201-vjzfzshh	149	5	the	the	DT
cord-256201-vjzfzshh	149	6	virus	virus	NN
cord-256201-vjzfzshh	149	7	carrying	carry	VBG
cord-256201-vjzfzshh	149	8	the	the	DT
cord-256201-vjzfzshh	149	9	C3934G	c3934g	CD
cord-256201-vjzfzshh	149	10	/	/	SYM
cord-256201-vjzfzshh	149	11	C3935A	C3935A	NNP
cord-256201-vjzfzshh	149	12	substitutions	substitution	NNS
cord-256201-vjzfzshh	149	13	was	be	VBD
cord-256201-vjzfzshh	149	14	fourteen	fourteen	CD
cord-256201-vjzfzshh	149	15	times	time	NNS
cord-256201-vjzfzshh	149	16	lower	low	JJR
cord-256201-vjzfzshh	149	17	than	than	IN
cord-256201-vjzfzshh	149	18	the	the	DT
cord-256201-vjzfzshh	149	19	WT	WT	NNP
cord-256201-vjzfzshh	149	20	(	(	-LRB-
cord-256201-vjzfzshh	149	21	t	t	NN
cord-256201-vjzfzshh	149	22	-	-	HYPH
cord-256201-vjzfzshh	149	23	test	test	NN
cord-256201-vjzfzshh	149	24	:	:	:
cord-256201-vjzfzshh	149	25	P	p	NN
cord-256201-vjzfzshh	149	26	<	<	XX
cord-256201-vjzfzshh	149	27	0.001	0.001	CD
cord-256201-vjzfzshh	149	28	;	;	:
cord-256201-vjzfzshh	149	29	Table	table	NN
cord-256201-vjzfzshh	149	30	1	1	CD
cord-256201-vjzfzshh	149	31	)	)	-RRB-
cord-256201-vjzfzshh	149	32	,	,	,
cord-256201-vjzfzshh	149	33	whereas	whereas	IN
cord-256201-vjzfzshh	149	34	substitutions	substitution	NNS
cord-256201-vjzfzshh	149	35	A3940G	A3940G	NNP
cord-256201-vjzfzshh	149	36	/	/	SYM
cord-256201-vjzfzshh	149	37	T3943C	T3943C	NNP
cord-256201-vjzfzshh	149	38	were	be	VBD
cord-256201-vjzfzshh	149	39	unable	unable	JJ
cord-256201-vjzfzshh	149	40	to	to	TO
cord-256201-vjzfzshh	149	41	reduce	reduce	VB
cord-256201-vjzfzshh	149	42	the	the	DT
cord-256201-vjzfzshh	149	43	mutation	mutation	NN
cord-256201-vjzfzshh	149	44	rate	rate	NN
cord-256201-vjzfzshh	149	45	below	below	IN
cord-256201-vjzfzshh	149	46	the	the	DT
cord-256201-vjzfzshh	149	47	WT	WT	NNP
cord-256201-vjzfzshh	149	48	level	level	NN
cord-256201-vjzfzshh	149	49	(	(	-LRB-
cord-256201-vjzfzshh	149	50	P	p	NN
cord-256201-vjzfzshh	149	51	¼	¼	CD
cord-256201-vjzfzshh	149	52	0.132	0.132	CD
cord-256201-vjzfzshh	149	53	)	)	-RRB-
cord-256201-vjzfzshh	149	54	despite	despite	IN
cord-256201-vjzfzshh	149	55	being	be	VBG
cord-256201-vjzfzshh	149	56	located	locate	VBN
cord-256201-vjzfzshh	149	57	only	only	RB
cord-256201-vjzfzshh	149	58	five	five	CD
cord-256201-vjzfzshh	149	59	bases	basis	NNS
cord-256201-vjzfzshh	149	60	away	away	RB
cord-256201-vjzfzshh	149	61	from	from	IN
cord-256201-vjzfzshh	149	62	the	the	DT
cord-256201-vjzfzshh	149	63	previous	previous	JJ
cord-256201-vjzfzshh	149	64	substitutions	substitution	NNS
cord-256201-vjzfzshh	149	65	.	.	.
cord-256201-vjzfzshh	150	1	Therefore	therefore	RB
cord-256201-vjzfzshh	150	2	,	,	,
cord-256201-vjzfzshh	150	3	some	some	DT
cord-256201-vjzfzshh	150	4	but	but	CC
cord-256201-vjzfzshh	150	5	not	not	RB
cord-256201-vjzfzshh	150	6	all	all	DT
cord-256201-vjzfzshh	150	7	intergenic	intergenic	JJ
cord-256201-vjzfzshh	150	8	GATCs	GATCs	NNPS
cord-256201-vjzfzshh	150	9	are	be	VBP
cord-256201-vjzfzshh	150	10	able	able	JJ
cord-256201-vjzfzshh	150	11	to	to	TO
cord-256201-vjzfzshh	150	12	promote	promote	VB
cord-256201-vjzfzshh	150	13	MMR	MMR	NNP
cord-256201-vjzfzshh	150	14	,	,	,
cord-256201-vjzfzshh	150	15	and	and	CC
cord-256201-vjzfzshh	150	16	minute	minute	NN
cord-256201-vjzfzshh	150	17	changes	change	NNS
cord-256201-vjzfzshh	150	18	in	in	IN
cord-256201-vjzfzshh	150	19	their	-PRON-	PRP$
cord-256201-vjzfzshh	150	20	genome	genome	NN
cord-256201-vjzfzshh	150	21	location	location	NN
cord-256201-vjzfzshh	150	22	lead	lead	NN
cord-256201-vjzfzshh	150	23	to	to	IN
cord-256201-vjzfzshh	150	24	marked	marked	JJ
cord-256201-vjzfzshh	150	25	differences	difference	NNS
cord-256201-vjzfzshh	150	26	in	in	IN
cord-256201-vjzfzshh	150	27	mutation	mutation	NN
cord-256201-vjzfzshh	150	28	rate	rate	NN
cord-256201-vjzfzshh	150	29	.	.	.
cord-256201-vjzfzshh	151	1	Induction	induction	NN
cord-256201-vjzfzshh	151	2	of	of	IN
cord-256201-vjzfzshh	151	3	the	the	DT
cord-256201-vjzfzshh	151	4	chaperone	chaperone	NN
cord-256201-vjzfzshh	151	5	-	-	HYPH
cord-256201-vjzfzshh	151	6	encoding	encode	VBG
cord-256201-vjzfzshh	151	7	groE	groe	CD
cord-256201-vjzfzshh	151	8	operon	operon	NN
cord-256201-vjzfzshh	151	9	in	in	IN
cord-256201-vjzfzshh	151	10	response	response	NN
cord-256201-vjzfzshh	151	11	to	to	TO
cord-256201-vjzfzshh	151	12	heat	heat	VB
cord-256201-vjzfzshh	151	13	shocks	shock	NNS
cord-256201-vjzfzshh	151	14	up	up	RP
cord-256201-vjzfzshh	151	15	-	-	HYPH
cord-256201-vjzfzshh	151	16	regulates	regulate	VBZ
cord-256201-vjzfzshh	151	17	the	the	DT
cord-256201-vjzfzshh	151	18	expression	expression	NN
cord-256201-vjzfzshh	151	19	of	of	IN
cord-256201-vjzfzshh	151	20	the	the	DT
cord-256201-vjzfzshh	151	21	error	error	NN
cord-256201-vjzfzshh	151	22	-	-	HYPH
cord-256201-vjzfzshh	151	23	prone	prone	JJ
cord-256201-vjzfzshh	151	24	DNA	dna	NN
cord-256201-vjzfzshh	151	25	polymerase	polymerase	NN
cord-256201-vjzfzshh	151	26	IV	IV	NNP
cord-256201-vjzfzshh	151	27	,	,	,
cord-256201-vjzfzshh	151	28	which	which	WDT
cord-256201-vjzfzshh	151	29	participates	participate	VBZ
cord-256201-vjzfzshh	151	30	in	in	IN
cord-256201-vjzfzshh	151	31	the	the	DT
cord-256201-vjzfzshh	151	32	repair	repair	NN
cord-256201-vjzfzshh	151	33	of	of	IN
cord-256201-vjzfzshh	151	34	dsDNA	dsdna	JJ
cord-256201-vjzfzshh	151	35	breaks	break	NNS
cord-256201-vjzfzshh	151	36	under	under	IN
cord-256201-vjzfzshh	151	37	different	different	JJ
cord-256201-vjzfzshh	151	38	types	type	NNS
cord-256201-vjzfzshh	151	39	of	of	IN
cord-256201-vjzfzshh	151	40	cellular	cellular	JJ
cord-256201-vjzfzshh	151	41	stress	stress	NN
cord-256201-vjzfzshh	151	42	,	,	,
cord-256201-vjzfzshh	151	43	leading	lead	VBG
cord-256201-vjzfzshh	151	44	to	to	IN
cord-256201-vjzfzshh	151	45	stress	stress	NN
cord-256201-vjzfzshh	151	46	-	-	HYPH
cord-256201-vjzfzshh	151	47	induced	induce	VBN
cord-256201-vjzfzshh	151	48	mutagenesis	mutagenesis	NN
cord-256201-vjzfzshh	151	49	(	(	-LRB-
cord-256201-vjzfzshh	151	50	Layton	Layton	NNP
cord-256201-vjzfzshh	151	51	and	and	CC
cord-256201-vjzfzshh	151	52	Foster	Foster	NNP
cord-256201-vjzfzshh	151	53	2005	2005	CD
cord-256201-vjzfzshh	151	54	;	;	:
cord-256201-vjzfzshh	152	1	Malkova	Malkova	NNP
cord-256201-vjzfzshh	152	2	and	and	CC
cord-256201-vjzfzshh	152	3	Haber	Haber	NNP
cord-256201-vjzfzshh	152	4	2012	2012	CD
cord-256201-vjzfzshh	152	5	)	)	-RRB-
cord-256201-vjzfzshh	152	6	.	.	.
cord-256201-vjzfzshh	153	1	To	to	TO
cord-256201-vjzfzshh	153	2	address	address	VB
cord-256201-vjzfzshh	153	3	the	the	DT
cord-256201-vjzfzshh	153	4	effects	effect	NNS
cord-256201-vjzfzshh	153	5	of	of	IN
cord-256201-vjzfzshh	153	6	heat	heat	NN
cord-256201-vjzfzshh	153	7	shocks	shock	NNS
cord-256201-vjzfzshh	153	8	on	on	IN
cord-256201-vjzfzshh	153	9	the	the	DT
cord-256201-vjzfzshh	153	10	/X174	/X174	NFP
cord-256201-vjzfzshh	153	11	mutation	mutation	NN
cord-256201-vjzfzshh	153	12	rate	rate	NN
cord-256201-vjzfzshh	153	13	,	,	,
cord-256201-vjzfzshh	153	14	we	-PRON-	PRP
cord-256201-vjzfzshh	153	15	performed	perform	VBD
cord-256201-vjzfzshh	153	16	fluctuation	fluctuation	NN
cord-256201-vjzfzshh	153	17	tests	test	NNS
cord-256201-vjzfzshh	153	18	at	at	IN
cord-256201-vjzfzshh	153	19	42	42	CD
cord-256201-vjzfzshh	153	20	C	c	NN
cord-256201-vjzfzshh	153	21	for	for	IN
cord-256201-vjzfzshh	153	22	the	the	DT
cord-256201-vjzfzshh	153	23	WT	WT	NNP
cord-256201-vjzfzshh	153	24	and	and	CC
cord-256201-vjzfzshh	153	25	20GATC	20gatc	CD
cord-256201-vjzfzshh	153	26	viruses	virus	NNS
cord-256201-vjzfzshh	153	27	.	.	.
cord-256201-vjzfzshh	154	1	The	the	DT
cord-256201-vjzfzshh	154	2	mutation	mutation	NN
cord-256201-vjzfzshh	154	3	rate	rate	NN
cord-256201-vjzfzshh	154	4	of	of	IN
cord-256201-vjzfzshh	154	5	the	the	DT
cord-256201-vjzfzshh	154	6	WT	WT	NNP
cord-256201-vjzfzshh	154	7	was	be	VBD
cord-256201-vjzfzshh	154	8	not	not	RB
cord-256201-vjzfzshh	154	9	significantly	significantly	RB
cord-256201-vjzfzshh	154	10	affected	affect	VBN
cord-256201-vjzfzshh	154	11	by	by	IN
cord-256201-vjzfzshh	154	12	the	the	DT
cord-256201-vjzfzshh	154	13	temperature	temperature	NN
cord-256201-vjzfzshh	154	14	shift	shift	NN
cord-256201-vjzfzshh	154	15	(	(	-LRB-
cord-256201-vjzfzshh	154	16	t	t	NN
cord-256201-vjzfzshh	154	17	-	-	HYPH
cord-256201-vjzfzshh	154	18	test	test	NN
cord-256201-vjzfzshh	154	19	:	:	:
cord-256201-vjzfzshh	155	1	P	p	NN
cord-256201-vjzfzshh	155	2	¼	¼	NNP
cord-256201-vjzfzshh	155	3	0.585	0.585	CD
cord-256201-vjzfzshh	155	4	;	;	:
cord-256201-vjzfzshh	155	5	Table	table	NN
cord-256201-vjzfzshh	155	6	2	2	CD
cord-256201-vjzfzshh	155	7	;	;	:
cord-256201-vjzfzshh	156	1	Fig	Fig	NNP
cord-256201-vjzfzshh	156	2	.	.	.
cord-256201-vjzfzshh	156	3	4A	4a	CD
cord-256201-vjzfzshh	156	4	)	)	-RRB-
cord-256201-vjzfzshh	156	5	.	.	.
cord-256201-vjzfzshh	157	1	In	in	IN
cord-256201-vjzfzshh	157	2	contrast	contrast	NN
cord-256201-vjzfzshh	157	3	,	,	,
cord-256201-vjzfzshh	157	4	the	the	DT
cord-256201-vjzfzshh	157	5	mutation	mutation	NN
cord-256201-vjzfzshh	157	6	rate	rate	NN
cord-256201-vjzfzshh	157	7	of	of	IN
cord-256201-vjzfzshh	157	8	the	the	DT
cord-256201-vjzfzshh	157	9	20GATC	20gatc	CD
cord-256201-vjzfzshh	157	10	virus	virus	NN
cord-256201-vjzfzshh	157	11	was	be	VBD
cord-256201-vjzfzshh	157	12	twenty	twenty	CD
cord-256201-vjzfzshh	157	13	times	time	NNS
cord-256201-vjzfzshh	157	14	higher	high	JJR
cord-256201-vjzfzshh	157	15	at	at	IN
cord-256201-vjzfzshh	157	16	42	42	CD
cord-256201-vjzfzshh	157	17	C	c	NN
cord-256201-vjzfzshh	157	18	than	than	IN
cord-256201-vjzfzshh	157	19	at	at	IN
cord-256201-vjzfzshh	157	20	37	37	CD
cord-256201-vjzfzshh	157	21	C	c	NN
cord-256201-vjzfzshh	157	22	(	(	-LRB-
cord-256201-vjzfzshh	157	23	t	t	NN
cord-256201-vjzfzshh	157	24	-	-	HYPH
cord-256201-vjzfzshh	157	25	test	test	NN
cord-256201-vjzfzshh	157	26	:	:	:
cord-256201-vjzfzshh	158	1	P	p	NN
cord-256201-vjzfzshh	158	2	<	<	XX
cord-256201-vjzfzshh	158	3	0.001	0.001	CD
cord-256201-vjzfzshh	158	4	)	)	-RRB-
cord-256201-vjzfzshh	158	5	and	and	CC
cord-256201-vjzfzshh	158	6	increased	increase	VBD
cord-256201-vjzfzshh	158	7	even	even	RB
cord-256201-vjzfzshh	158	8	above	above	IN
cord-256201-vjzfzshh	158	9	the	the	DT
cord-256201-vjzfzshh	158	10	WT	WT	NNP
cord-256201-vjzfzshh	158	11	level	level	NN
cord-256201-vjzfzshh	158	12	(	(	-LRB-
cord-256201-vjzfzshh	158	13	P	p	NN
cord-256201-vjzfzshh	158	14	¼	¼	CD
cord-256201-vjzfzshh	158	15	0.003	0.003	CD
cord-256201-vjzfzshh	158	16	)	)	-RRB-
cord-256201-vjzfzshh	158	17	.	.	.
cord-256201-vjzfzshh	159	1	Therefore	therefore	RB
cord-256201-vjzfzshh	159	2	,	,	,
cord-256201-vjzfzshh	159	3	the	the	DT
cord-256201-vjzfzshh	159	4	effects	effect	NNS
cord-256201-vjzfzshh	159	5	of	of	IN
cord-256201-vjzfzshh	159	6	GATC	GATC	NNP
cord-256201-vjzfzshh	159	7	sites	site	NNS
cord-256201-vjzfzshh	159	8	on	on	IN
cord-256201-vjzfzshh	159	9	the	the	DT
cord-256201-vjzfzshh	159	10	/X174	/X174	NFP
cord-256201-vjzfzshh	159	11	mutation	mutation	NN
cord-256201-vjzfzshh	159	12	rate	rate	NN
cord-256201-vjzfzshh	159	13	observed	observe	VBD
cord-256201-vjzfzshh	159	14	at	at	IN
cord-256201-vjzfzshh	159	15	37	37	CD
cord-256201-vjzfzshh	159	16	C	C	NNP
cord-256201-vjzfzshh	159	17	were	be	VBD
cord-256201-vjzfzshh	159	18	reverted	revert	VBN
cord-256201-vjzfzshh	159	19	at	at	IN
cord-256201-vjzfzshh	159	20	42	42	CD
cord-256201-vjzfzshh	159	21	C.	C.	NNP
cord-256201-vjzfzshh	159	22	Heat	Heat	NNP
cord-256201-vjzfzshh	159	23	drastically	drastically	RB
cord-256201-vjzfzshh	159	24	reduced	reduce	VBD
cord-256201-vjzfzshh	159	25	the	the	DT
cord-256201-vjzfzshh	159	26	viral	viral	JJ
cord-256201-vjzfzshh	159	27	growth	growth	NN
cord-256201-vjzfzshh	159	28	rate	rate	NN
cord-256201-vjzfzshh	159	29	but	but	CC
cord-256201-vjzfzshh	159	30	,	,	,
cord-256201-vjzfzshh	159	31	whereas	whereas	IN
cord-256201-vjzfzshh	159	32	the	the	DT
cord-256201-vjzfzshh	159	33	WT	WT	NNP
cord-256201-vjzfzshh	159	34	and	and	CC
cord-256201-vjzfzshh	159	35	20GATC	20gatc	CD
cord-256201-vjzfzshh	159	36	viruses	virus	NNS
cord-256201-vjzfzshh	159	37	showed	show	VBD
cord-256201-vjzfzshh	159	38	similar	similar	JJ
cord-256201-vjzfzshh	159	39	growth	growth	NN
cord-256201-vjzfzshh	159	40	rates	rate	NNS
cord-256201-vjzfzshh	159	41	at	at	IN
cord-256201-vjzfzshh	159	42	37	37	CD
cord-256201-vjzfzshh	159	43	C	c	NN
cord-256201-vjzfzshh	159	44	,	,	,
cord-256201-vjzfzshh	159	45	the	the	DT
cord-256201-vjzfzshh	159	46	20GATC	20gatc	CD
cord-256201-vjzfzshh	159	47	virus	virus	NN
cord-256201-vjzfzshh	159	48	grew	grow	VBD
cord-256201-vjzfzshh	159	49	significantly	significantly	RB
cord-256201-vjzfzshh	159	50	slower	slow	JJR
cord-256201-vjzfzshh	159	51	than	than	IN
cord-256201-vjzfzshh	159	52	the	the	DT
cord-256201-vjzfzshh	159	53	WT	WT	NNP
cord-256201-vjzfzshh	159	54	at	at	IN
cord-256201-vjzfzshh	159	55	42	42	CD
cord-256201-vjzfzshh	159	56	C	C	NNP
cord-256201-vjzfzshh	159	57	(	(	-LRB-
cord-256201-vjzfzshh	159	58	2.23	2.23	CD
cord-256201-vjzfzshh	159	59	6	6	CD
cord-256201-vjzfzshh	159	60	0.19	0.19	CD
cord-256201-vjzfzshh	159	61	h	h	NN
cord-256201-vjzfzshh	159	62	-1	-1	NNP
cord-256201-vjzfzshh	159	63	versus	versus	IN
cord-256201-vjzfzshh	159	64	3.81	3.81	CD
cord-256201-vjzfzshh	159	65	6	6	CD
cord-256201-vjzfzshh	159	66	0.24	0.24	CD
cord-256201-vjzfzshh	159	67	h	h	NN
cord-256201-vjzfzshh	159	68	-1	-1	NN
cord-256201-vjzfzshh	159	69	;	;	:
cord-256201-vjzfzshh	159	70	t	t	NN
cord-256201-vjzfzshh	159	71	-	-	HYPH
cord-256201-vjzfzshh	159	72	test	test	NN
cord-256201-vjzfzshh	159	73	:	:	:
cord-256201-vjzfzshh	159	74	P	p	NN
cord-256201-vjzfzshh	159	75	¼	¼	CD
cord-256201-vjzfzshh	159	76	0.007	0.007	CD
cord-256201-vjzfzshh	159	77	;	;	:
cord-256201-vjzfzshh	159	78	Table	table	NN
cord-256201-vjzfzshh	159	79	2	2	CD
cord-256201-vjzfzshh	159	80	;	;	:
cord-256201-vjzfzshh	159	81	Fig	fig	NN
cord-256201-vjzfzshh	159	82	.	.	.
cord-256201-vjzfzshh	159	83	4B	4b	CD
cord-256201-vjzfzshh	159	84	)	)	-RRB-
cord-256201-vjzfzshh	159	85	,	,	,
cord-256201-vjzfzshh	159	86	suggesting	suggest	VBG
cord-256201-vjzfzshh	159	87	that	that	IN
cord-256201-vjzfzshh	159	88	up	up	NN
cord-256201-vjzfzshh	159	89	-	-	HYPH
cord-256201-vjzfzshh	159	90	regulation	regulation	NN
cord-256201-vjzfzshh	159	91	of	of	IN
cord-256201-vjzfzshh	159	92	repair	repair	NN
cord-256201-vjzfzshh	159	93	pathways	pathway	NNS
cord-256201-vjzfzshh	159	94	under	under	IN
cord-256201-vjzfzshh	159	95	thermal	thermal	JJ
cord-256201-vjzfzshh	159	96	stress	stress	NN
cord-256201-vjzfzshh	159	97	slows	slow	VBZ
cord-256201-vjzfzshh	159	98	down	down	RP
cord-256201-vjzfzshh	159	99	phage	phage	NN
cord-256201-vjzfzshh	159	100	replication	replication	NN
cord-256201-vjzfzshh	159	101	.	.	.
cord-256201-vjzfzshh	160	1	To	to	TO
cord-256201-vjzfzshh	160	2	evaluate	evaluate	VB
cord-256201-vjzfzshh	160	3	the	the	DT
cord-256201-vjzfzshh	160	4	effects	effect	NNS
cord-256201-vjzfzshh	160	5	of	of	IN
cord-256201-vjzfzshh	160	6	another	another	DT
cord-256201-vjzfzshh	160	7	stressor	stressor	NN
cord-256201-vjzfzshh	160	8	,	,	,
cord-256201-vjzfzshh	160	9	we	-PRON-	PRP
cord-256201-vjzfzshh	160	10	treated	treat	VBD
cord-256201-vjzfzshh	160	11	cells	cell	NNS
cord-256201-vjzfzshh	160	12	with	with	IN
cord-256201-vjzfzshh	160	13	5-FU	5-fu	CD
cord-256201-vjzfzshh	160	14	(	(	-LRB-
cord-256201-vjzfzshh	160	15	10	10	CD
cord-256201-vjzfzshh	160	16	ng	ng	NN
cord-256201-vjzfzshh	160	17	/	/	SYM
cord-256201-vjzfzshh	160	18	ml	ml	NN
cord-256201-vjzfzshh	160	19	)	)	-RRB-
cord-256201-vjzfzshh	160	20	which	which	WDT
cord-256201-vjzfzshh	160	21	,	,	,
cord-256201-vjzfzshh	160	22	in	in	IN
cord-256201-vjzfzshh	160	23	addition	addition	NN
cord-256201-vjzfzshh	160	24	to	to	IN
cord-256201-vjzfzshh	160	25	causing	cause	VBG
cord-256201-vjzfzshh	160	26	mutations	mutation	NNS
cord-256201-vjzfzshh	160	27	directly	directly	RB
cord-256201-vjzfzshh	160	28	by	by	IN
cord-256201-vjzfzshh	160	29	base	base	NN
cord-256201-vjzfzshh	160	30	mispairing	mispairing	NN
cord-256201-vjzfzshh	160	31	,	,	,
cord-256201-vjzfzshh	160	32	5-FU	5-fu	ADD
cord-256201-vjzfzshh	160	33	inhibits	inhibit	VBZ
cord-256201-vjzfzshh	160	34	thymidylate	thymidylate	NN
cord-256201-vjzfzshh	160	35	synthase	synthase	NN
cord-256201-vjzfzshh	160	36	,	,	,
cord-256201-vjzfzshh	160	37	leading	lead	VBG
cord-256201-vjzfzshh	160	38	to	to	IN
cord-256201-vjzfzshh	160	39	deoxythymidine	deoxythymidine	NNP
cord-256201-vjzfzshh	160	40	monophosphate	monophosphate	NN
cord-256201-vjzfzshh	160	41	deprivation	deprivation	NN
cord-256201-vjzfzshh	160	42	and	and	CC
cord-256201-vjzfzshh	160	43	,	,	,
cord-256201-vjzfzshh	160	44	subsequently	subsequently	RB
cord-256201-vjzfzshh	160	45	,	,	,
cord-256201-vjzfzshh	160	46	to	to	IN
cord-256201-vjzfzshh	160	47	DNA	dna	NN
cord-256201-vjzfzshh	160	48	strand	strand	NN
cord-256201-vjzfzshh	160	49	breaks	break	NNS
cord-256201-vjzfzshh	160	50	,	,	,
cord-256201-vjzfzshh	160	51	induction	induction	NN
cord-256201-vjzfzshh	160	52	of	of	IN
cord-256201-vjzfzshh	160	53	the	the	DT
cord-256201-vjzfzshh	160	54	SOS	SOS	NNP
cord-256201-vjzfzshh	160	55	DNA	DNA	NNP
cord-256201-vjzfzshh	160	56	damage	damage	NN
cord-256201-vjzfzshh	160	57	response	response	NN
cord-256201-vjzfzshh	160	58	(	(	-LRB-
cord-256201-vjzfzshh	160	59	DDR	DDR	NNP
cord-256201-vjzfzshh	160	60	)	)	-RRB-
cord-256201-vjzfzshh	160	61	,	,	,
cord-256201-vjzfzshh	160	62	and	and	CC
cord-256201-vjzfzshh	160	63	expression	expression	NN
cord-256201-vjzfzshh	160	64	of	of	IN
cord-256201-vjzfzshh	160	65	error	error	NN
cord-256201-vjzfzshh	160	66	-	-	HYPH
cord-256201-vjzfzshh	160	67	prone	prone	JJ
cord-256201-vjzfzshh	160	68	DNA	dna	NN
cord-256201-vjzfzshh	160	69	repair	repair	NN
cord-256201-vjzfzshh	160	70	enzymes	enzyme	NNS
cord-256201-vjzfzshh	160	71	(	(	-LRB-
cord-256201-vjzfzshh	160	72	Ahmad	Ahmad	NNP
cord-256201-vjzfzshh	160	73	,	,	,
cord-256201-vjzfzshh	160	74	Kirk	Kirk	NNP
cord-256201-vjzfzshh	160	75	,	,	,
cord-256201-vjzfzshh	160	76	and	and	CC
cord-256201-vjzfzshh	160	77	Eisenstark	Eisenstark	NNP
cord-256201-vjzfzshh	160	78	1998	1998	CD
cord-256201-vjzfzshh	160	79	;	;	:
cord-256201-vjzfzshh	160	80	Fonville	Fonville	NNP
cord-256201-vjzfzshh	160	81	et	et	NNP
cord-256201-vjzfzshh	160	82	al	al	NNP
cord-256201-vjzfzshh	160	83	.	.	NNP
cord-256201-vjzfzshh	160	84	2010	2010	CD
cord-256201-vjzfzshh	160	85	)	)	-RRB-
cord-256201-vjzfzshh	160	86	.	.	.
cord-256201-vjzfzshh	161	1	Previously	previously	RB
cord-256201-vjzfzshh	161	2	,	,	,
cord-256201-vjzfzshh	161	3	we	-PRON-	PRP
cord-256201-vjzfzshh	161	4	showed	show	VBD
cord-256201-vjzfzshh	161	5	that	that	IN
cord-256201-vjzfzshh	161	6	this	this	DT
cord-256201-vjzfzshh	161	7	treatment	treatment	NN
cord-256201-vjzfzshh	161	8	increases	increase	VBZ
cord-256201-vjzfzshh	161	9	the	the	DT
cord-256201-vjzfzshh	161	10	mutation	mutation	NN
cord-256201-vjzfzshh	161	11	rate	rate	NN
cord-256201-vjzfzshh	161	12	of	of	IN
cord-256201-vjzfzshh	161	13	the	the	DT
cord-256201-vjzfzshh	161	14	WT	WT	NNP
cord-256201-vjzfzshh	161	15	virus	virus	NN
cord-256201-vjzfzshh	161	16	by	by	IN
cord-256201-vjzfzshh	161	17	approximately	approximately	RB
cord-256201-vjzfzshh	161	18	tenfold	tenfold	RB
cord-256201-vjzfzshh	162	1	(	(	-LRB-
cord-256201-vjzfzshh	162	2	Domingo	Domingo	NNP
cord-256201-vjzfzshh	162	3	-	-	HYPH
cord-256201-vjzfzshh	162	4	Calap	Calap	NNP
cord-256201-vjzfzshh	162	5	,	,	,
cord-256201-vjzfzshh	162	6	Pereira	Pereira	NNP
cord-256201-vjzfzshh	162	7	-	-	HYPH
cord-256201-vjzfzshh	162	8	Gomez	Gomez	NNP
cord-256201-vjzfzshh	162	9	,	,	,
cord-256201-vjzfzshh	162	10	and	and	CC
cord-256201-vjzfzshh	162	11	Sanjuán	Sanjuán	NNP
cord-256201-vjzfzshh	162	12	2012	2012	CD
cord-256201-vjzfzshh	162	13	)	)	-RRB-
cord-256201-vjzfzshh	162	14	.	.	.
cord-256201-vjzfzshh	163	1	Fluctuation	fluctuation	NN
cord-256201-vjzfzshh	163	2	tests	test	NNS
cord-256201-vjzfzshh	163	3	in	in	IN
cord-256201-vjzfzshh	163	4	the	the	DT
cord-256201-vjzfzshh	163	5	presence	presence	NN
cord-256201-vjzfzshh	163	6	of	of	IN
cord-256201-vjzfzshh	163	7	10	10	CD
cord-256201-vjzfzshh	163	8	ng	ng	NN
cord-256201-vjzfzshh	163	9	/	/	SYM
cord-256201-vjzfzshh	163	10	ml	ml	NN
cord-256201-vjzfzshh	163	11	5-FU	5-fu	CD
cord-256201-vjzfzshh	163	12	showed	show	VBD
cord-256201-vjzfzshh	163	13	that	that	IN
cord-256201-vjzfzshh	163	14	the	the	DT
cord-256201-vjzfzshh	163	15	drug	drug	NN
cord-256201-vjzfzshh	163	16	had	have	VBD
cord-256201-vjzfzshh	163	17	a	a	DT
cord-256201-vjzfzshh	163	18	more	more	RBR
cord-256201-vjzfzshh	163	19	pronounced	pronounced	JJ
cord-256201-vjzfzshh	163	20	effect	effect	NN
cord-256201-vjzfzshh	163	21	on	on	IN
cord-256201-vjzfzshh	163	22	the	the	DT
cord-256201-vjzfzshh	163	23	mutation	mutation	NN
cord-256201-vjzfzshh	163	24	rate	rate	NN
cord-256201-vjzfzshh	163	25	of	of	IN
cord-256201-vjzfzshh	163	26	the	the	DT
cord-256201-vjzfzshh	163	27	20GATC	20gatc	CD
cord-256201-vjzfzshh	163	28	virus	virus	NN
cord-256201-vjzfzshh	163	29	,	,	,
cord-256201-vjzfzshh	163	30	which	which	WDT
cord-256201-vjzfzshh	163	31	increased	increase	VBD
cord-256201-vjzfzshh	163	32	more	more	JJR
cord-256201-vjzfzshh	163	33	than	than	IN
cord-256201-vjzfzshh	163	34	a	a	DT
cord-256201-vjzfzshh	163	35	100-fold	100-fold	CD
cord-256201-vjzfzshh	163	36	(	(	-LRB-
cord-256201-vjzfzshh	163	37	Table	table	NN
cord-256201-vjzfzshh	163	38	2	2	CD
cord-256201-vjzfzshh	163	39	;	;	:
cord-256201-vjzfzshh	163	40	Fig	Fig	NNP
cord-256201-vjzfzshh	163	41	.	.	.
cord-256201-vjzfzshh	163	42	4A	4a	CD
cord-256201-vjzfzshh	163	43	)	)	-RRB-
cord-256201-vjzfzshh	163	44	.	.	.
cord-256201-vjzfzshh	164	1	As	as	IN
cord-256201-vjzfzshh	164	2	a	a	DT
cord-256201-vjzfzshh	164	3	result	result	NN
cord-256201-vjzfzshh	164	4	,	,	,
cord-256201-vjzfzshh	164	5	the	the	DT
cord-256201-vjzfzshh	164	6	difference	difference	NN
cord-256201-vjzfzshh	164	7	in	in	IN
cord-256201-vjzfzshh	164	8	mutation	mutation	NN
cord-256201-vjzfzshh	164	9	rate	rate	NN
cord-256201-vjzfzshh	164	10	between	between	IN
cord-256201-vjzfzshh	164	11	the	the	DT
cord-256201-vjzfzshh	164	12	20GATC	20gatc	CD
cord-256201-vjzfzshh	164	13	and	and	CC
cord-256201-vjzfzshh	164	14	WT	WT	NNP
cord-256201-vjzfzshh	164	15	viruses	virus	NNS
cord-256201-vjzfzshh	164	16	was	be	VBD
cord-256201-vjzfzshh	164	17	fully	fully	RB
cord-256201-vjzfzshh	164	18	abolished	abolish	VBN
cord-256201-vjzfzshh	164	19	in	in	IN
cord-256201-vjzfzshh	164	20	the	the	DT
cord-256201-vjzfzshh	164	21	presence	presence	NN
cord-256201-vjzfzshh	164	22	of	of	IN
cord-256201-vjzfzshh	164	23	5-FU	5-fu	CD
cord-256201-vjzfzshh	164	24	(	(	-LRB-
cord-256201-vjzfzshh	164	25	t	t	NN
cord-256201-vjzfzshh	164	26	-	-	HYPH
cord-256201-vjzfzshh	164	27	test	test	NN
cord-256201-vjzfzshh	164	28	:	:	:
cord-256201-vjzfzshh	164	29	P	p	NN
cord-256201-vjzfzshh	164	30	¼	¼	CD
cord-256201-vjzfzshh	164	31	0.951	0.951	CD
cord-256201-vjzfzshh	164	32	)	)	-RRB-
cord-256201-vjzfzshh	164	33	.	.	.
cord-256201-vjzfzshh	165	1	We	-PRON-	PRP
cord-256201-vjzfzshh	165	2	have	have	VBP
cord-256201-vjzfzshh	165	3	shown	show	VBN
cord-256201-vjzfzshh	165	4	that	that	DT
cord-256201-vjzfzshh	165	5	introduction	introduction	NN
cord-256201-vjzfzshh	165	6	of	of	IN
cord-256201-vjzfzshh	165	7	GATC	GATC	NNP
cord-256201-vjzfzshh	165	8	sites	site	NNS
cord-256201-vjzfzshh	165	9	in	in	IN
cord-256201-vjzfzshh	165	10	the	the	DT
cord-256201-vjzfzshh	165	11	/X174	/X174	NFP
cord-256201-vjzfzshh	165	12	genome	genome	NN
cord-256201-vjzfzshh	165	13	can	can	MD
cord-256201-vjzfzshh	165	14	reduce	reduce	VB
cord-256201-vjzfzshh	165	15	the	the	DT
cord-256201-vjzfzshh	165	16	spontaneous	spontaneous	JJ
cord-256201-vjzfzshh	165	17	mutation	mutation	NN
cord-256201-vjzfzshh	165	18	rate	rate	NN
cord-256201-vjzfzshh	165	19	of	of	IN
cord-256201-vjzfzshh	165	20	the	the	DT
cord-256201-vjzfzshh	165	21	phage	phage	NN
cord-256201-vjzfzshh	165	22	by	by	IN
cord-256201-vjzfzshh	165	23	up	up	IN
cord-256201-vjzfzshh	165	24	to	to	IN
cord-256201-vjzfzshh	165	25	fiftyfold	fiftyfold	NN
cord-256201-vjzfzshh	165	26	,	,	,
cord-256201-vjzfzshh	165	27	indicating	indicate	VBG
cord-256201-vjzfzshh	165	28	that	that	IN
cord-256201-vjzfzshh	165	29	phage	phage	NN
cord-256201-vjzfzshh	165	30	DNA	dna	NN
cord-256201-vjzfzshh	165	31	can	can	MD
cord-256201-vjzfzshh	165	32	undergo	undergo	VB
cord-256201-vjzfzshh	165	33	MMR	MMR	NNP
cord-256201-vjzfzshh	165	34	if	if	IN
cord-256201-vjzfzshh	165	35	the	the	DT
cord-256201-vjzfzshh	165	36	required	require	VBN
cord-256201-vjzfzshh	165	37	sequence	sequence	NN
cord-256201-vjzfzshh	165	38	motifs	motif	NNS
cord-256201-vjzfzshh	165	39	are	be	VBP
cord-256201-vjzfzshh	165	40	present	present	JJ
cord-256201-vjzfzshh	165	41	.	.	.
cord-256201-vjzfzshh	166	1	The	the	DT
cord-256201-vjzfzshh	166	2	effect	effect	NN
cord-256201-vjzfzshh	166	3	of	of	IN
cord-256201-vjzfzshh	166	4	GATC	GATC	NNP
cord-256201-vjzfzshh	166	5	addition	addition	NN
cord-256201-vjzfzshh	166	6	is	be	VBZ
cord-256201-vjzfzshh	166	7	greater	great	JJR
cord-256201-vjzfzshh	166	8	than	than	IN
cord-256201-vjzfzshh	166	9	those	those	DT
cord-256201-vjzfzshh	166	10	reported	report	VBN
cord-256201-vjzfzshh	166	11	previously	previously	RB
cord-256201-vjzfzshh	166	12	in	in	IN
cord-256201-vjzfzshh	166	13	RNA	RNA	NNP
cord-256201-vjzfzshh	166	14	viruses	virus	NNS
cord-256201-vjzfzshh	166	15	,	,	,
cord-256201-vjzfzshh	166	16	in	in	IN
cord-256201-vjzfzshh	166	17	which	which	WDT
cord-256201-vjzfzshh	166	18	high	high	JJ
cord-256201-vjzfzshh	166	19	-	-	HYPH
cord-256201-vjzfzshh	166	20	fidelity	fidelity	NN
cord-256201-vjzfzshh	166	21	polymerase	polymerase	NN
cord-256201-vjzfzshh	166	22	variants	variant	NNS
cord-256201-vjzfzshh	166	23	selected	select	VBN
cord-256201-vjzfzshh	166	24	after	after	IN
cord-256201-vjzfzshh	166	25	serial	serial	JJ
cord-256201-vjzfzshh	166	26	transfers	transfer	NNS
cord-256201-vjzfzshh	166	27	in	in	IN
cord-256201-vjzfzshh	166	28	the	the	DT
cord-256201-vjzfzshh	166	29	presence	presence	NN
cord-256201-vjzfzshh	166	30	of	of	IN
cord-256201-vjzfzshh	166	31	nucleoside	nucleoside	JJ
cord-256201-vjzfzshh	166	32	analogs	analog	NNS
cord-256201-vjzfzshh	166	33	typically	typically	RB
cord-256201-vjzfzshh	166	34	reduce	reduce	VBP
cord-256201-vjzfzshh	166	35	the	the	DT
cord-256201-vjzfzshh	166	36	viral	viral	JJ
cord-256201-vjzfzshh	166	37	mutation	mutation	NN
cord-256201-vjzfzshh	166	38	rate	rate	NN
cord-256201-vjzfzshh	166	39	by	by	IN
cord-256201-vjzfzshh	166	40	threefold	threefold	NN
cord-256201-vjzfzshh	166	41	or	or	CC
cord-256201-vjzfzshh	166	42	less	less	JJR
cord-256201-vjzfzshh	167	1	(	(	-LRB-
cord-256201-vjzfzshh	167	2	Pfeiffer	Pfeiffer	NNP
cord-256201-vjzfzshh	167	3	and	and	CC
cord-256201-vjzfzshh	167	4	Kirkegaard	Kirkegaard	NNP
cord-256201-vjzfzshh	167	5	2003	2003	CD
cord-256201-vjzfzshh	167	6	;	;	:
cord-256201-vjzfzshh	167	7	Coffey	Coffey	NNP
cord-256201-vjzfzshh	167	8	et	et	NNP
cord-256201-vjzfzshh	167	9	al	al	NNP
cord-256201-vjzfzshh	167	10	.	.	NNP
cord-256201-vjzfzshh	167	11	2011	2011	CD
cord-256201-vjzfzshh	167	12	)	)	-RRB-
cord-256201-vjzfzshh	167	13	.	.	.
cord-256201-vjzfzshh	168	1	A	a	DT
cord-256201-vjzfzshh	168	2	similarly	similarly	RB
cord-256201-vjzfzshh	168	3	modest	modest	JJ
cord-256201-vjzfzshh	168	4	effect	effect	NN
cord-256201-vjzfzshh	168	5	was	be	VBD
cord-256201-vjzfzshh	168	6	observed	observe	VBN
cord-256201-vjzfzshh	168	7	after	after	IN
cord-256201-vjzfzshh	168	8	serial	serial	JJ
cord-256201-vjzfzshh	168	9	passaging	passaging	NN
cord-256201-vjzfzshh	168	10	of	of	IN
cord-256201-vjzfzshh	168	11	/X174	/X174	.
cord-256201-vjzfzshh	169	1	in	in	IN
cord-256201-vjzfzshh	169	2	the	the	DT
cord-256201-vjzfzshh	169	3	presence	presence	NN
cord-256201-vjzfzshh	169	4	of	of	IN
cord-256201-vjzfzshh	169	5	5-FU	5-fu	CD
cord-256201-vjzfzshh	170	1	(	(	-LRB-
cord-256201-vjzfzshh	170	2	Domingo	Domingo	NNP
cord-256201-vjzfzshh	170	3	-	-	HYPH
cord-256201-vjzfzshh	170	4	Calap	Calap	NNP
cord-256201-vjzfzshh	170	5	,	,	,
cord-256201-vjzfzshh	170	6	Pereira	Pereira	NNP
cord-256201-vjzfzshh	170	7	-	-	HYPH
cord-256201-vjzfzshh	170	8	Gomez	Gomez	NNP
cord-256201-vjzfzshh	170	9	,	,	,
cord-256201-vjzfzshh	170	10	and	and	CC
cord-256201-vjzfzshh	170	11	Sanjuá	Sanjuá	NNP
cord-256201-vjzfzshh	170	12	n	n	NNP
cord-256201-vjzfzshh	170	13	2012	2012	CD
cord-256201-vjzfzshh	170	14	)	)	-RRB-
cord-256201-vjzfzshh	170	15	.	.	.
cord-256201-vjzfzshh	171	1	In	in	IN
cord-256201-vjzfzshh	171	2	that	that	DT
cord-256201-vjzfzshh	171	3	case	case	NN
cord-256201-vjzfzshh	171	4	,	,	,
cord-256201-vjzfzshh	171	5	the	the	DT
cord-256201-vjzfzshh	171	6	anti	anti	JJ
cord-256201-vjzfzshh	171	7	-	-	JJ
cord-256201-vjzfzshh	171	8	mutator	mutator	JJ
cord-256201-vjzfzshh	171	9	phenotype	phenotype	NN
cord-256201-vjzfzshh	171	10	was	be	VBD
cord-256201-vjzfzshh	171	11	achieved	achieve	VBN
cord-256201-vjzfzshh	171	12	by	by	IN
cord-256201-vjzfzshh	171	13	a	a	DT
cord-256201-vjzfzshh	171	14	delayed	delay	VBN
cord-256201-vjzfzshh	171	15	lysis	lysis	NN
cord-256201-vjzfzshh	171	16	,	,	,
cord-256201-vjzfzshh	171	17	which	which	WDT
cord-256201-vjzfzshh	171	18	increased	increase	VBD
cord-256201-vjzfzshh	171	19	the	the	DT
cord-256201-vjzfzshh	171	20	viral	viral	JJ
cord-256201-vjzfzshh	171	21	burst	burst	NN
cord-256201-vjzfzshh	171	22	size	size	NN
cord-256201-vjzfzshh	171	23	per	per	IN
cord-256201-vjzfzshh	171	24	cell	cell	NN
cord-256201-vjzfzshh	171	25	and	and	CC
cord-256201-vjzfzshh	171	26	thus	thus	RB
cord-256201-vjzfzshh	171	27	allowed	allow	VBD
cord-256201-vjzfzshh	171	28	the	the	DT
cord-256201-vjzfzshh	171	29	phage	phage	NN
cord-256201-vjzfzshh	171	30	to	to	TO
cord-256201-vjzfzshh	171	31	expand	expand	VB
cord-256201-vjzfzshh	171	32	its	-PRON-	PRP$
cord-256201-vjzfzshh	171	33	population	population	NN
cord-256201-vjzfzshh	171	34	size	size	NN
cord-256201-vjzfzshh	171	35	in	in	IN
cord-256201-vjzfzshh	171	36	fewer	few	JJR
cord-256201-vjzfzshh	171	37	rounds	round	NNS
cord-256201-vjzfzshh	171	38	of	of	IN
cord-256201-vjzfzshh	171	39	copying	copying	NN
cord-256201-vjzfzshh	172	1	(	(	-LRB-
cord-256201-vjzfzshh	172	2	Pereira	Pereira	NNP
cord-256201-vjzfzshh	172	3	-	-	HYPH
cord-256201-vjzfzshh	172	4	Gó	Gó	NNP
cord-256201-vjzfzshh	172	5	mez	mez	NNP
cord-256201-vjzfzshh	172	6	and	and	CC
cord-256201-vjzfzshh	172	7	Sanjuá	Sanjuá	NNP
cord-256201-vjzfzshh	172	8	n	n	NNP
cord-256201-vjzfzshh	172	9	2014	2014	CD
cord-256201-vjzfzshh	172	10	)	)	-RRB-
cord-256201-vjzfzshh	172	11	.	.	.
cord-256201-vjzfzshh	173	1	In	in	IN
cord-256201-vjzfzshh	173	2	the	the	DT
cord-256201-vjzfzshh	173	3	dsDNA	dsdna	JJ
cord-256201-vjzfzshh	173	4	bacteriophage	bacteriophage	NN
cord-256201-vjzfzshh	173	5	T4	T4	NNP
cord-256201-vjzfzshh	173	6	,	,	,
cord-256201-vjzfzshh	173	7	a	a	DT
cord-256201-vjzfzshh	173	8	series	series	NN
cord-256201-vjzfzshh	173	9	of	of	IN
cord-256201-vjzfzshh	173	10	polymerase	polymerase	NN
cord-256201-vjzfzshh	173	11	variants	variant	NNS
cord-256201-vjzfzshh	173	12	capable	capable	JJ
cord-256201-vjzfzshh	173	13	of	of	IN
cord-256201-vjzfzshh	173	14	strongly	strongly	RB
cord-256201-vjzfzshh	173	15	suppressing	suppress	VBG
cord-256201-vjzfzshh	173	16	the	the	DT
cord-256201-vjzfzshh	173	17	action	action	NN
cord-256201-vjzfzshh	173	18	of	of	IN
cord-256201-vjzfzshh	173	19	chemical	chemical	NN
cord-256201-vjzfzshh	173	20	mutagens	mutagen	NNS
cord-256201-vjzfzshh	173	21	were	be	VBD
cord-256201-vjzfzshh	173	22	isolated	isolate	VBN
cord-256201-vjzfzshh	173	23	in	in	IN
cord-256201-vjzfzshh	173	24	early	early	JJ
cord-256201-vjzfzshh	173	25	studies	study	NNS
cord-256201-vjzfzshh	173	26	(	(	-LRB-
cord-256201-vjzfzshh	173	27	Drake	Drake	NNP
cord-256201-vjzfzshh	173	28	et	et	NNP
cord-256201-vjzfzshh	173	29	al	al	NNP
cord-256201-vjzfzshh	173	30	.	.	NNP
cord-256201-vjzfzshh	173	31	1969	1969	CD
cord-256201-vjzfzshh	173	32	;	;	:
cord-256201-vjzfzshh	173	33	Drake	Drake	NNP
cord-256201-vjzfzshh	173	34	and	and	CC
cord-256201-vjzfzshh	173	35	Greening	Greening	NNP
cord-256201-vjzfzshh	173	36	1970	1970	CD
cord-256201-vjzfzshh	173	37	)	)	-RRB-
cord-256201-vjzfzshh	173	38	.	.	.
cord-256201-vjzfzshh	174	1	However	however	RB
cord-256201-vjzfzshh	174	2	,	,	,
cord-256201-vjzfzshh	174	3	high	high	JJ
cord-256201-vjzfzshh	174	4	fidelity	fidelity	NN
cord-256201-vjzfzshh	174	5	variants	variant	NNS
cord-256201-vjzfzshh	174	6	of	of	IN
cord-256201-vjzfzshh	174	7	T4	T4	NNP
cord-256201-vjzfzshh	174	8	polymerase	polymerase	NN
cord-256201-vjzfzshh	174	9	tend	tend	VBP
cord-256201-vjzfzshh	174	10	to	to	TO
cord-256201-vjzfzshh	174	11	show	show	VB
cord-256201-vjzfzshh	174	12	diminished	diminished	JJ
cord-256201-vjzfzshh	174	13	polymerization	polymerization	NN
cord-256201-vjzfzshh	174	14	rates	rate	NNS
cord-256201-vjzfzshh	174	15	,	,	,
cord-256201-vjzfzshh	174	16	therefore	therefore	RB
cord-256201-vjzfzshh	174	17	negatively	negatively	RB
cord-256201-vjzfzshh	174	18	impacting	impact	VBG
cord-256201-vjzfzshh	174	19	viral	viral	JJ
cord-256201-vjzfzshh	174	20	fitness	fitness	NN
cord-256201-vjzfzshh	174	21	(	(	-LRB-
cord-256201-vjzfzshh	174	22	Mansky	Mansky	NNP
cord-256201-vjzfzshh	174	23	and	and	CC
cord-256201-vjzfzshh	174	24	Cunningham	Cunningham	NNP
cord-256201-vjzfzshh	174	25	2000	2000	CD
cord-256201-vjzfzshh	174	26	)	)	-RRB-
cord-256201-vjzfzshh	174	27	.	.	.
cord-256201-vjzfzshh	175	1	In	in	IN
cord-256201-vjzfzshh	175	2	E.	E.	NNP
cord-256201-vjzfzshh	175	3	coli	coli	NNS
cord-256201-vjzfzshh	175	4	,	,	,
cord-256201-vjzfzshh	175	5	Figure	figure	NN
cord-256201-vjzfzshh	175	6	3	3	CD
cord-256201-vjzfzshh	175	7	.	.	.
cord-256201-vjzfzshh	176	1	Restriction	restriction	NN
cord-256201-vjzfzshh	176	2	fragment	fragment	NN
cord-256201-vjzfzshh	176	3	analysis	analysis	NN
cord-256201-vjzfzshh	176	4	of	of	IN
cord-256201-vjzfzshh	176	5	the	the	DT
cord-256201-vjzfzshh	176	6	/X174	/X174	NFP
cord-256201-vjzfzshh	176	7	replicative	replicative	JJ
cord-256201-vjzfzshh	176	8	dsDNA	dsdna	RB
cord-256201-vjzfzshh	176	9	.	.	.
cord-256201-vjzfzshh	177	1	Phage	phage	NN
cord-256201-vjzfzshh	177	2	dsDNA	dsdna	RB
cord-256201-vjzfzshh	177	3	was	be	VBD
cord-256201-vjzfzshh	177	4	purified	purify	VBN
cord-256201-vjzfzshh	177	5	by	by	IN
cord-256201-vjzfzshh	177	6	standard	standard	JJ
cord-256201-vjzfzshh	177	7	miniprep	miniprep	NNP
cord-256201-vjzfzshh	177	8	as	as	IN
cord-256201-vjzfzshh	177	9	described	describe	VBN
cord-256201-vjzfzshh	177	10	in	in	IN
cord-256201-vjzfzshh	177	11	the	the	DT
cord-256201-vjzfzshh	177	12	Materials	Materials	NNPS
cord-256201-vjzfzshh	177	13	and	and	CC
cord-256201-vjzfzshh	177	14	Methods	Methods	NNPS
cord-256201-vjzfzshh	177	15	section	section	NN
cord-256201-vjzfzshh	177	16	and	and	CC
cord-256201-vjzfzshh	177	17	linearized	linearize	VBN
cord-256201-vjzfzshh	177	18	with	with	IN
cord-256201-vjzfzshh	177	19	XhoI	XhoI	NNP
cord-256201-vjzfzshh	177	20	(	(	-LRB-
cord-256201-vjzfzshh	177	21	ø	ø	NN
cord-256201-vjzfzshh	177	22	)	)	-RRB-
cord-256201-vjzfzshh	177	23	,	,	,
cord-256201-vjzfzshh	177	24	which	which	WDT
cord-256201-vjzfzshh	177	25	recognizes	recognize	VBZ
cord-256201-vjzfzshh	177	26	a	a	DT
cord-256201-vjzfzshh	177	27	unique	unique	JJ
cord-256201-vjzfzshh	177	28	site	site	NN
cord-256201-vjzfzshh	177	29	at	at	IN
cord-256201-vjzfzshh	177	30	position	position	NN
cord-256201-vjzfzshh	177	31	162	162	CD
cord-256201-vjzfzshh	177	32	,	,	,
cord-256201-vjzfzshh	177	33	with	with	IN
cord-256201-vjzfzshh	177	34	XhoI	XhoI	NNP
cord-256201-vjzfzshh	177	35	and	and	CC
cord-256201-vjzfzshh	177	36	DpnI	DpnI	NNP
cord-256201-vjzfzshh	177	37	to	to	TO
cord-256201-vjzfzshh	177	38	cleave	cleave	VB
cord-256201-vjzfzshh	177	39	methylated	methylate	VBN
cord-256201-vjzfzshh	177	40	or	or	CC
cord-256201-vjzfzshh	177	41	hemi	hemi	NN
cord-256201-vjzfzshh	177	42	-	-	HYPH
cord-256201-vjzfzshh	177	43	methylated	methylate	VBN
cord-256201-vjzfzshh	177	44	GATCs	GATCs	NNP
cord-256201-vjzfzshh	177	45	,	,	,
cord-256201-vjzfzshh	177	46	or	or	CC
cord-256201-vjzfzshh	177	47	with	with	IN
cord-256201-vjzfzshh	177	48	XhoI	XhoI	NNP
cord-256201-vjzfzshh	177	49	and	and	CC
cord-256201-vjzfzshh	177	50	MboI	MboI	NNP
cord-256201-vjzfzshh	177	51	to	to	TO
cord-256201-vjzfzshh	177	52	cleave	cleave	VB
cord-256201-vjzfzshh	177	53	non	non	JJ
cord-256201-vjzfzshh	177	54	-	-	JJ
cord-256201-vjzfzshh	177	55	methylated	methylated	JJ
cord-256201-vjzfzshh	177	56	GATCs	gatc	NNS
cord-256201-vjzfzshh	177	57	.	.	.
cord-256201-vjzfzshh	178	1	Expected	expect	VBN
cord-256201-vjzfzshh	178	2	(	(	-LRB-
cord-256201-vjzfzshh	178	3	left	leave	VBN
cord-256201-vjzfzshh	178	4	)	)	-RRB-
cord-256201-vjzfzshh	178	5	and	and	CC
cord-256201-vjzfzshh	178	6	observed	observe	VBD
cord-256201-vjzfzshh	178	7	(	(	-LRB-
cord-256201-vjzfzshh	178	8	center	center	NN
cord-256201-vjzfzshh	178	9	)	)	-RRB-
cord-256201-vjzfzshh	178	10	restriction	restriction	NN
cord-256201-vjzfzshh	178	11	fragments	fragment	NNS
cord-256201-vjzfzshh	178	12	for	for	IN
cord-256201-vjzfzshh	178	13	the	the	DT
cord-256201-vjzfzshh	178	14	WT	WT	NNP
cord-256201-vjzfzshh	178	15	and	and	CC
cord-256201-vjzfzshh	178	16	4GATC	4gatc	CD
cord-256201-vjzfzshh	178	17	phage	phage	NN
cord-256201-vjzfzshh	179	1	dsDNA	dsDNA	NNP
cord-256201-vjzfzshh	179	2	are	be	VBP
cord-256201-vjzfzshh	179	3	shown	show	VBN
cord-256201-vjzfzshh	179	4	.	.	.
cord-256201-vjzfzshh	180	1	Lower	low	JJR
cord-256201-vjzfzshh	180	2	size	size	NN
cord-256201-vjzfzshh	180	3	fragments	fragment	NNS
cord-256201-vjzfzshh	180	4	(	(	-LRB-
cord-256201-vjzfzshh	180	5	<	<	NNP
cord-256201-vjzfzshh	180	6	300	300	CD
cord-256201-vjzfzshh	180	7	bp	bp	NNP
cord-256201-vjzfzshh	180	8	,	,	,
cord-256201-vjzfzshh	180	9	Fig	Fig	NNP
cord-256201-vjzfzshh	180	10	.	.	NNP
cord-256201-vjzfzshh	180	11	1	1	CD
cord-256201-vjzfzshh	180	12	)	)	-RRB-
cord-256201-vjzfzshh	180	13	were	be	VBD
cord-256201-vjzfzshh	180	14	expected	expect	VBN
cord-256201-vjzfzshh	180	15	but	but	CC
cord-256201-vjzfzshh	180	16	could	could	MD
cord-256201-vjzfzshh	180	17	not	not	RB
cord-256201-vjzfzshh	180	18	be	be	VB
cord-256201-vjzfzshh	180	19	visualized	visualize	VBN
cord-256201-vjzfzshh	180	20	because	because	IN
cord-256201-vjzfzshh	180	21	the	the	DT
cord-256201-vjzfzshh	180	22	amount	amount	NN
cord-256201-vjzfzshh	180	23	of	of	IN
cord-256201-vjzfzshh	180	24	input	input	NN
cord-256201-vjzfzshh	180	25	DNA	dna	NN
cord-256201-vjzfzshh	180	26	was	be	VBD
cord-256201-vjzfzshh	180	27	low	low	JJ
cord-256201-vjzfzshh	180	28	.	.	.
cord-256201-vjzfzshh	181	1	The	the	DT
cord-256201-vjzfzshh	181	2	smear	smear	NN
cord-256201-vjzfzshh	181	3	in	in	IN
cord-256201-vjzfzshh	181	4	lanes	lane	NNS
cord-256201-vjzfzshh	181	5	containing	contain	VBG
cord-256201-vjzfzshh	181	6	the	the	DT
cord-256201-vjzfzshh	181	7	purified	purify	VBN
cord-256201-vjzfzshh	181	8	phage	phage	NN
cord-256201-vjzfzshh	181	9	DNA	dna	NN
cord-256201-vjzfzshh	181	10	probably	probably	RB
cord-256201-vjzfzshh	181	11	results	result	VBZ
cord-256201-vjzfzshh	181	12	from	from	IN
cord-256201-vjzfzshh	181	13	degradation	degradation	NN
cord-256201-vjzfzshh	181	14	of	of	IN
cord-256201-vjzfzshh	181	15	host	host	NN
cord-256201-vjzfzshh	181	16	DNA	dna	NN
cord-256201-vjzfzshh	181	17	.	.	.
cord-256201-vjzfzshh	182	1	The	the	DT
cord-256201-vjzfzshh	182	2	contrast	contrast	NN
cord-256201-vjzfzshh	182	3	of	of	IN
cord-256201-vjzfzshh	182	4	the	the	DT
cord-256201-vjzfzshh	182	5	gel	gel	NN
cord-256201-vjzfzshh	182	6	image	image	NN
cord-256201-vjzfzshh	182	7	was	be	VBD
cord-256201-vjzfzshh	182	8	enhanced	enhance	VBN
cord-256201-vjzfzshh	182	9	to	to	TO
cord-256201-vjzfzshh	182	10	help	help	VB
cord-256201-vjzfzshh	182	11	visualize	visualize	VB
cord-256201-vjzfzshh	182	12	bands	band	NNS
cord-256201-vjzfzshh	182	13	.	.	.
cord-256201-vjzfzshh	183	1	Right	right	RB
cord-256201-vjzfzshh	183	2	:	:	:
cord-256201-vjzfzshh	183	3	percent	percent	NN
cord-256201-vjzfzshh	183	4	abundance	abundance	NN
cord-256201-vjzfzshh	183	5	of	of	IN
cord-256201-vjzfzshh	183	6	each	each	DT
cord-256201-vjzfzshh	183	7	DpnI	DpnI	NNP
cord-256201-vjzfzshh	183	8	and	and	CC
cord-256201-vjzfzshh	183	9	MboI	MboI	NNP
cord-256201-vjzfzshh	183	10	restriction	restriction	NN
cord-256201-vjzfzshh	183	11	band	band	NN
cord-256201-vjzfzshh	183	12	(	(	-LRB-
cord-256201-vjzfzshh	183	13	1	1	CD
cord-256201-vjzfzshh	183	14	-	-	SYM
cord-256201-vjzfzshh	183	15	4	4	CD
cord-256201-vjzfzshh	183	16	)	)	-RRB-
cord-256201-vjzfzshh	183	17	.	.	.
cord-256201-vjzfzshh	184	1	Band	band	NN
cord-256201-vjzfzshh	184	2	1	1	CD
cord-256201-vjzfzshh	184	3	in	in	IN
cord-256201-vjzfzshh	184	4	the	the	DT
cord-256201-vjzfzshh	184	5	DpnI	DpnI	NNP
cord-256201-vjzfzshh	184	6	lane	lane	NN
cord-256201-vjzfzshh	184	7	indicates	indicate	VBZ
cord-256201-vjzfzshh	184	8	the	the	DT
cord-256201-vjzfzshh	184	9	non	non	JJ
cord-256201-vjzfzshh	184	10	-	-	JJ
cord-256201-vjzfzshh	184	11	methylated	methylated	JJ
cord-256201-vjzfzshh	184	12	DNA	dna	NN
cord-256201-vjzfzshh	184	13	fraction	fraction	NN
cord-256201-vjzfzshh	184	14	(	(	-LRB-
cord-256201-vjzfzshh	184	15	i.e.	i.e.	FW
cord-256201-vjzfzshh	184	16	,	,	,
cord-256201-vjzfzshh	184	17	none	none	NN
cord-256201-vjzfzshh	184	18	of	of	IN
cord-256201-vjzfzshh	184	19	the	the	DT
cord-256201-vjzfzshh	184	20	four	four	CD
cord-256201-vjzfzshh	184	21	GATC	GATC	NNP
cord-256201-vjzfzshh	184	22	motifs	motif	NNS
cord-256201-vjzfzshh	184	23	was	be	VBD
cord-256201-vjzfzshh	184	24	methylated	methylate	VBN
cord-256201-vjzfzshh	184	25	)	)	-RRB-
cord-256201-vjzfzshh	184	26	,	,	,
cord-256201-vjzfzshh	184	27	whereas	whereas	IN
cord-256201-vjzfzshh	184	28	in	in	IN
cord-256201-vjzfzshh	184	29	the	the	DT
cord-256201-vjzfzshh	184	30	MboI	MboI	NNP
cord-256201-vjzfzshh	184	31	lane	lane	NN
cord-256201-vjzfzshh	184	32	,	,	,
cord-256201-vjzfzshh	184	33	this	this	DT
cord-256201-vjzfzshh	184	34	same	same	JJ
cord-256201-vjzfzshh	184	35	band	band	NN
cord-256201-vjzfzshh	184	36	indicates	indicate	VBZ
cord-256201-vjzfzshh	184	37	the	the	DT
cord-256201-vjzfzshh	184	38	fully	fully	RB
cord-256201-vjzfzshh	184	39	methylated	methylate	VBN
cord-256201-vjzfzshh	184	40	fraction	fraction	NN
cord-256201-vjzfzshh	184	41	(	(	-LRB-
cord-256201-vjzfzshh	184	42	i.e.	i.e.	FW
cord-256201-vjzfzshh	184	43	,	,	,
cord-256201-vjzfzshh	184	44	the	the	DT
cord-256201-vjzfzshh	184	45	four	four	CD
cord-256201-vjzfzshh	184	46	GATC	GATC	NNP
cord-256201-vjzfzshh	184	47	motifs	motif	NNS
cord-256201-vjzfzshh	184	48	were	be	VBD
cord-256201-vjzfzshh	184	49	methylated	methylate	VBN
cord-256201-vjzfzshh	184	50	)	)	-RRB-
cord-256201-vjzfzshh	184	51	.	.	.
cord-256201-vjzfzshh	185	1	Bands	band	NNS
cord-256201-vjzfzshh	185	2	were	be	VBD
cord-256201-vjzfzshh	185	3	quantified	quantify	VBN
cord-256201-vjzfzshh	185	4	as	as	IN
cord-256201-vjzfzshh	185	5	detailed	detail	VBN
cord-256201-vjzfzshh	185	6	in	in	IN
cord-256201-vjzfzshh	185	7	the	the	DT
cord-256201-vjzfzshh	185	8	Materials	Materials	NNPS
cord-256201-vjzfzshh	185	9	and	and	CC
cord-256201-vjzfzshh	185	10	Methods	Methods	NNPS
cord-256201-vjzfzshh	185	11	section	section	NN
cord-256201-vjzfzshh	185	12	using	use	VBG
cord-256201-vjzfzshh	185	13	the	the	DT
cord-256201-vjzfzshh	185	14	raw	raw	JJ
cord-256201-vjzfzshh	185	15	gel	gel	NN
cord-256201-vjzfzshh	185	16	image	image	NN
cord-256201-vjzfzshh	185	17	with	with	IN
cord-256201-vjzfzshh	185	18	no	no	DT
cord-256201-vjzfzshh	185	19	contrast	contrast	NN
cord-256201-vjzfzshh	185	20	enhancement	enhancement	NN
cord-256201-vjzfzshh	185	21	.	.	.
cord-256201-vjzfzshh	186	1	changes	change	NNS
cord-256201-vjzfzshh	186	2	in	in	IN
cord-256201-vjzfzshh	186	3	the	the	DT
cord-256201-vjzfzshh	186	4	a	a	DT
cord-256201-vjzfzshh	186	5	subunit	subunit	NN
cord-256201-vjzfzshh	186	6	of	of	IN
cord-256201-vjzfzshh	186	7	DNA	dna	NN
cord-256201-vjzfzshh	186	8	polymerase	polymerase	NN
cord-256201-vjzfzshh	186	9	III	III	NNP
cord-256201-vjzfzshh	186	10	can	can	MD
cord-256201-vjzfzshh	186	11	increase	increase	VB
cord-256201-vjzfzshh	186	12	replication	replication	NN
cord-256201-vjzfzshh	186	13	fidelity	fidelity	NN
cord-256201-vjzfzshh	186	14	between	between	IN
cord-256201-vjzfzshh	186	15	two	two	CD
cord-256201-vjzfzshh	186	16	-	-	HYPH
cord-256201-vjzfzshh	186	17	and	and	CC
cord-256201-vjzfzshh	186	18	thirtyfold	thirtyfold	JJ
cord-256201-vjzfzshh	186	19	(	(	-LRB-
cord-256201-vjzfzshh	186	20	Fijalkowska	Fijalkowska	NNP
cord-256201-vjzfzshh	186	21	,	,	,
cord-256201-vjzfzshh	186	22	Dunn	Dunn	NNP
cord-256201-vjzfzshh	186	23	,	,	,
cord-256201-vjzfzshh	186	24	and	and	CC
cord-256201-vjzfzshh	186	25	Schaaper	Schaaper	NNP
cord-256201-vjzfzshh	186	26	1993	1993	CD
cord-256201-vjzfzshh	186	27	)	)	-RRB-
cord-256201-vjzfzshh	186	28	.	.	.
cord-256201-vjzfzshh	187	1	A	a	DT
cord-256201-vjzfzshh	187	2	stronger	strong	JJR
cord-256201-vjzfzshh	187	3	anti	anti	JJ
cord-256201-vjzfzshh	187	4	-	-	JJ
cord-256201-vjzfzshh	187	5	mutator	mutator	JJ
cord-256201-vjzfzshh	187	6	phenotype	phenotype	NN
cord-256201-vjzfzshh	187	7	was	be	VBD
cord-256201-vjzfzshh	187	8	found	find	VBN
cord-256201-vjzfzshh	187	9	in	in	IN
cord-256201-vjzfzshh	187	10	the	the	DT
cord-256201-vjzfzshh	187	11	adenine	adenine	NN
cord-256201-vjzfzshh	187	12	-	-	HYPH
cord-256201-vjzfzshh	187	13	dependent	dependent	JJ
cord-256201-vjzfzshh	187	14	E.	E.	NNP
cord-256201-vjzfzshh	187	15	coli	coli	NNS
cord-256201-vjzfzshh	187	16	mud	mud	NN
cord-256201-vjzfzshh	187	17	strain	strain	NN
cord-256201-vjzfzshh	187	18	,	,	,
cord-256201-vjzfzshh	187	19	but	but	CC
cord-256201-vjzfzshh	187	20	latter	latter	JJ
cord-256201-vjzfzshh	187	21	analyses	analysis	NNS
cord-256201-vjzfzshh	187	22	suggested	suggest	VBD
cord-256201-vjzfzshh	187	23	that	that	IN
cord-256201-vjzfzshh	187	24	this	this	DT
cord-256201-vjzfzshh	187	25	was	be	VBD
cord-256201-vjzfzshh	187	26	probably	probably	RB
cord-256201-vjzfzshh	187	27	due	due	JJ
cord-256201-vjzfzshh	187	28	to	to	IN
cord-256201-vjzfzshh	187	29	poor	poor	JJ
cord-256201-vjzfzshh	187	30	detection	detection	NN
cord-256201-vjzfzshh	187	31	of	of	IN
cord-256201-vjzfzshh	187	32	mutants	mutant	NNS
cord-256201-vjzfzshh	187	33	(	(	-LRB-
cord-256201-vjzfzshh	187	34	Schaaper	Schaaper	NNP
cord-256201-vjzfzshh	187	35	1998	1998	CD
cord-256201-vjzfzshh	187	36	)	)	-RRB-
cord-256201-vjzfzshh	187	37	.	.	.
cord-256201-vjzfzshh	188	1	In	in	IN
cord-256201-vjzfzshh	188	2	another	another	DT
cord-256201-vjzfzshh	188	3	study	study	NN
cord-256201-vjzfzshh	188	4	,	,	,
cord-256201-vjzfzshh	188	5	E.	E.	NNP
cord-256201-vjzfzshh	188	6	coli	coli	NNS
cord-256201-vjzfzshh	188	7	clones	clone	NNS
cord-256201-vjzfzshh	188	8	were	be	VBD
cord-256201-vjzfzshh	188	9	isolated	isolate	VBN
cord-256201-vjzfzshh	188	10	with	with	IN
cord-256201-vjzfzshh	188	11	an	an	DT
cord-256201-vjzfzshh	188	12	up	up	NN
cord-256201-vjzfzshh	188	13	to	to	IN
cord-256201-vjzfzshh	188	14	fiftyfold	fiftyfold	JJ
cord-256201-vjzfzshh	188	15	anti	anti	JJ
cord-256201-vjzfzshh	188	16	-	-	JJ
cord-256201-vjzfzshh	188	17	mutator	mutator	JJ
cord-256201-vjzfzshh	188	18	phenotype	phenotype	NN
cord-256201-vjzfzshh	188	19	,	,	,
cord-256201-vjzfzshh	188	20	but	but	CC
cord-256201-vjzfzshh	188	21	the	the	DT
cord-256201-vjzfzshh	188	22	underlying	underlie	VBG
cord-256201-vjzfzshh	188	23	mechanisms	mechanism	NNS
cord-256201-vjzfzshh	188	24	remained	remain	VBD
cord-256201-vjzfzshh	188	25	undetermined	undetermined	JJ
cord-256201-vjzfzshh	188	26	(	(	-LRB-
cord-256201-vjzfzshh	188	27	Quinones	Quinones	NNP
cord-256201-vjzfzshh	188	28	and	and	CC
cord-256201-vjzfzshh	188	29	Piechocki	Piechocki	NNP
cord-256201-vjzfzshh	188	30	1985	1985	CD
cord-256201-vjzfzshh	188	31	)	)	-RRB-
cord-256201-vjzfzshh	188	32	.	.	.
cord-256201-vjzfzshh	189	1	Therefore	therefore	RB
cord-256201-vjzfzshh	189	2	,	,	,
cord-256201-vjzfzshh	189	3	the	the	DT
cord-256201-vjzfzshh	189	4	magnitude	magnitude	NN
cord-256201-vjzfzshh	189	5	of	of	IN
cord-256201-vjzfzshh	189	6	the	the	DT
cord-256201-vjzfzshh	189	7	mutation	mutation	NN
cord-256201-vjzfzshh	189	8	rate	rate	NN
cord-256201-vjzfzshh	189	9	reduction	reduction	NN
cord-256201-vjzfzshh	189	10	afforded	afford	VBN
cord-256201-vjzfzshh	189	11	by	by	IN
cord-256201-vjzfzshh	189	12	the	the	DT
cord-256201-vjzfzshh	189	13	introduction	introduction	NN
cord-256201-vjzfzshh	189	14	of	of	IN
cord-256201-vjzfzshh	189	15	GATC	GATC	NNP
cord-256201-vjzfzshh	189	16	motifs	motif	NNS
cord-256201-vjzfzshh	189	17	is	be	VBZ
cord-256201-vjzfzshh	189	18	similar	similar	JJ
cord-256201-vjzfzshh	189	19	or	or	CC
cord-256201-vjzfzshh	189	20	higher	high	JJR
cord-256201-vjzfzshh	189	21	than	than	IN
cord-256201-vjzfzshh	189	22	those	those	DT
cord-256201-vjzfzshh	189	23	reported	report	VBN
cord-256201-vjzfzshh	189	24	previously	previously	RB
cord-256201-vjzfzshh	189	25	in	in	IN
cord-256201-vjzfzshh	189	26	other	other	JJ
cord-256201-vjzfzshh	189	27	viruses	virus	NNS
cord-256201-vjzfzshh	189	28	and	and	CC
cord-256201-vjzfzshh	189	29	in	in	IN
cord-256201-vjzfzshh	189	30	bacteria	bacteria	NNS
cord-256201-vjzfzshh	189	31	and	and	CC
cord-256201-vjzfzshh	189	32	has	have	VBZ
cord-256201-vjzfzshh	189	33	a	a	DT
cord-256201-vjzfzshh	189	34	well	well	RB
cord-256201-vjzfzshh	189	35	-	-	HYPH
cord-256201-vjzfzshh	189	36	defined	define	VBN
cord-256201-vjzfzshh	189	37	molecular	molecular	JJ
cord-256201-vjzfzshh	189	38	basis	basis	NN
cord-256201-vjzfzshh	189	39	.	.	.
cord-256201-vjzfzshh	190	1	Our	-PRON-	PRP$
cord-256201-vjzfzshh	190	2	results	result	NNS
cord-256201-vjzfzshh	190	3	suggest	suggest	VBP
cord-256201-vjzfzshh	190	4	that	that	IN
cord-256201-vjzfzshh	190	5	the	the	DT
cord-256201-vjzfzshh	190	6	/X174	/X174	NFP
cord-256201-vjzfzshh	190	7	mutation	mutation	NN
cord-256201-vjzfzshh	190	8	rate	rate	NN
cord-256201-vjzfzshh	190	9	can	can	MD
cord-256201-vjzfzshh	190	10	be	be	VB
cord-256201-vjzfzshh	190	11	modified	modify	VBN
cord-256201-vjzfzshh	190	12	without	without	IN
cord-256201-vjzfzshh	190	13	significantly	significantly	RB
cord-256201-vjzfzshh	190	14	impacting	impact	VBG
cord-256201-vjzfzshh	190	15	viral	viral	JJ
cord-256201-vjzfzshh	190	16	fitness	fitness	NN
cord-256201-vjzfzshh	190	17	in	in	IN
cord-256201-vjzfzshh	190	18	the	the	DT
cord-256201-vjzfzshh	190	19	short	short	JJ
cord-256201-vjzfzshh	190	20	-	-	HYPH
cord-256201-vjzfzshh	190	21	term	term	NN
cord-256201-vjzfzshh	190	22	,	,	,
cord-256201-vjzfzshh	190	23	therefore	therefore	RB
cord-256201-vjzfzshh	190	24	allowing	allow	VBG
cord-256201-vjzfzshh	190	25	for	for	IN
cord-256201-vjzfzshh	190	26	evolutionary	evolutionary	JJ
cord-256201-vjzfzshh	190	27	optimization	optimization	NN
cord-256201-vjzfzshh	190	28	of	of	IN
cord-256201-vjzfzshh	190	29	the	the	DT
cord-256201-vjzfzshh	190	30	viral	viral	JJ
cord-256201-vjzfzshh	190	31	mutation	mutation	NN
cord-256201-vjzfzshh	190	32	rate	rate	NN
cord-256201-vjzfzshh	190	33	for	for	IN
cord-256201-vjzfzshh	190	34	long	long	JJ
cord-256201-vjzfzshh	190	35	-	-	HYPH
cord-256201-vjzfzshh	190	36	term	term	NN
cord-256201-vjzfzshh	190	37	adaptability	adaptability	NN
cord-256201-vjzfzshh	190	38	.	.	.
cord-256201-vjzfzshh	191	1	However	however	RB
cord-256201-vjzfzshh	191	2	,	,	,
cord-256201-vjzfzshh	191	3	our	-PRON-	PRP$
cord-256201-vjzfzshh	191	4	results	result	NNS
cord-256201-vjzfzshh	191	5	also	also	RB
cord-256201-vjzfzshh	191	6	revealed	reveal	VBD
cord-256201-vjzfzshh	191	7	constraints	constraint	NNS
cord-256201-vjzfzshh	191	8	limiting	limit	VBG
cord-256201-vjzfzshh	191	9	mutation	mutation	NN
cord-256201-vjzfzshh	191	10	rate	rate	NN
cord-256201-vjzfzshh	191	11	evolution	evolution	NN
cord-256201-vjzfzshh	191	12	,	,	,
cord-256201-vjzfzshh	191	13	since	since	IN
cord-256201-vjzfzshh	191	14	the	the	DT
cord-256201-vjzfzshh	191	15	effects	effect	NNS
cord-256201-vjzfzshh	191	16	of	of	IN
cord-256201-vjzfzshh	191	17	GATC	GATC	NNP
cord-256201-vjzfzshh	191	18	addition	addition	NN
cord-256201-vjzfzshh	191	19	were	be	VBD
cord-256201-vjzfzshh	191	20	lower	low	JJR
cord-256201-vjzfzshh	191	21	than	than	IN
cord-256201-vjzfzshh	191	22	expected	expect	VBN
cord-256201-vjzfzshh	191	23	if	if	IN
cord-256201-vjzfzshh	191	24	MMR	MMR	NNP
cord-256201-vjzfzshh	191	25	were	be	VBD
cord-256201-vjzfzshh	191	26	fully	fully	RB
cord-256201-vjzfzshh	191	27	efficient	efficient	JJ
cord-256201-vjzfzshh	191	28	(	(	-LRB-
cord-256201-vjzfzshh	191	29	Fijalkowska	Fijalkowska	NNP
cord-256201-vjzfzshh	191	30	,	,	,
cord-256201-vjzfzshh	191	31	Schaaper	Schaaper	NNP
cord-256201-vjzfzshh	191	32	,	,	,
cord-256201-vjzfzshh	191	33	and	and	CC
cord-256201-vjzfzshh	191	34	Jonczyk	Jonczyk	NNP
cord-256201-vjzfzshh	191	35	2012	2012	CD
cord-256201-vjzfzshh	191	36	)	)	-RRB-
cord-256201-vjzfzshh	191	37	.	.	.
cord-256201-vjzfzshh	192	1	Illustrating	illustrate	VBG
cord-256201-vjzfzshh	192	2	this	this	DT
cord-256201-vjzfzshh	192	3	,	,	,
cord-256201-vjzfzshh	192	4	the	the	DT
cord-256201-vjzfzshh	192	5	lowest	low	JJS
cord-256201-vjzfzshh	192	6	mutation	mutation	NN
cord-256201-vjzfzshh	192	7	rate	rate	NN
cord-256201-vjzfzshh	192	8	achieved	achieve	VBN
cord-256201-vjzfzshh	192	9	in	in	IN
cord-256201-vjzfzshh	192	10	this	this	DT
cord-256201-vjzfzshh	192	11	study	study	NN
cord-256201-vjzfzshh	192	12	(	(	-LRB-
cord-256201-vjzfzshh	192	13	3	3	CD
cord-256201-vjzfzshh	192	14	Â	â	CD
cord-256201-vjzfzshh	192	15	10	10	CD
cord-256201-vjzfzshh	192	16	-8	-8	NNPS
cord-256201-vjzfzshh	192	17	m	m	NNP
cord-256201-vjzfzshh	192	18	/	/	SYM
cord-256201-vjzfzshh	192	19	n	n	NN
cord-256201-vjzfzshh	192	20	/	/	SYM
cord-256201-vjzfzshh	192	21	r	r	NN
cord-256201-vjzfzshh	192	22	)	)	-RRB-
cord-256201-vjzfzshh	192	23	was	be	VBD
cord-256201-vjzfzshh	192	24	still	still	RB
cord-256201-vjzfzshh	192	25	two	two	CD
cord-256201-vjzfzshh	192	26	orders	order	NNS
cord-256201-vjzfzshh	192	27	of	of	IN
cord-256201-vjzfzshh	192	28	magnitude	magnitude	NN
cord-256201-vjzfzshh	192	29	higher	high	JJR
cord-256201-vjzfzshh	192	30	than	than	IN
cord-256201-vjzfzshh	192	31	that	that	DT
cord-256201-vjzfzshh	192	32	of	of	IN
cord-256201-vjzfzshh	192	33	E.	E.	NNP
cord-256201-vjzfzshh	192	34	coli	coli	NNS
cord-256201-vjzfzshh	192	35	(	(	-LRB-
cord-256201-vjzfzshh	192	36	Drake	Drake	NNP
cord-256201-vjzfzshh	192	37	1991	1991	CD
cord-256201-vjzfzshh	192	38	;	;	:
cord-256201-vjzfzshh	192	39	Drake	Drake	NNP
cord-256201-vjzfzshh	192	40	et	et	NNP
cord-256201-vjzfzshh	192	41	al	al	NNP
cord-256201-vjzfzshh	192	42	.	.	.
cord-256201-vjzfzshh	193	1	1998	1998	CD
cord-256201-vjzfzshh	193	2	;	;	:
cord-256201-vjzfzshh	193	3	Lee	Lee	NNP
cord-256201-vjzfzshh	193	4	et	et	NNP
cord-256201-vjzfzshh	193	5	al	al	NNP
cord-256201-vjzfzshh	193	6	.	.	.
cord-256201-vjzfzshh	193	7	2012	2012	CD
cord-256201-vjzfzshh	193	8	)	)	-RRB-
cord-256201-vjzfzshh	193	9	.	.	.
cord-256201-vjzfzshh	194	1	Our	-PRON-	PRP$
cord-256201-vjzfzshh	194	2	results	result	NNS
cord-256201-vjzfzshh	194	3	suggest	suggest	VBP
cord-256201-vjzfzshh	194	4	that	that	IN
cord-256201-vjzfzshh	194	5	inefficient	inefficient	JJ
cord-256201-vjzfzshh	194	6	MMR	MMR	NNP
cord-256201-vjzfzshh	194	7	in	in	IN
cord-256201-vjzfzshh	194	8	/X174	/X174	,
cord-256201-vjzfzshh	194	9	is	be	VBZ
cord-256201-vjzfzshh	194	10	at	at	IN
cord-256201-vjzfzshh	194	11	least	least	JJS
cord-256201-vjzfzshh	194	12	in	in	IN
cord-256201-vjzfzshh	194	13	part	part	NN
cord-256201-vjzfzshh	194	14	due	due	IN
cord-256201-vjzfzshh	194	15	to	to	IN
cord-256201-vjzfzshh	194	16	the	the	DT
cord-256201-vjzfzshh	194	17	fact	fact	NN
cord-256201-vjzfzshh	194	18	that	that	IN
cord-256201-vjzfzshh	194	19	phage	phage	NN
cord-256201-vjzfzshh	194	20	DNA	dna	NN
cord-256201-vjzfzshh	194	21	is	be	VBZ
cord-256201-vjzfzshh	194	22	under	under	RB
cord-256201-vjzfzshh	194	23	-	-	HYPH
cord-256201-vjzfzshh	194	24	methylated	methylated	JJ
cord-256201-vjzfzshh	194	25	.	.	.
cord-256201-vjzfzshh	195	1	Full	full	JJ
cord-256201-vjzfzshh	195	2	methylation	methylation	NN
cord-256201-vjzfzshh	195	3	may	may	MD
cord-256201-vjzfzshh	195	4	be	be	VB
cord-256201-vjzfzshh	195	5	impeded	impede	VBN
cord-256201-vjzfzshh	195	6	by	by	IN
cord-256201-vjzfzshh	195	7	the	the	DT
cord-256201-vjzfzshh	195	8	fast	fast	JJ
cord-256201-vjzfzshh	195	9	replication	replication	NN
cord-256201-vjzfzshh	195	10	of	of	IN
cord-256201-vjzfzshh	195	11	the	the	DT
cord-256201-vjzfzshh	195	12	phage	phage	NN
cord-256201-vjzfzshh	195	13	and	and	CC
cord-256201-vjzfzshh	195	14	the	the	DT
cord-256201-vjzfzshh	195	15	transient	transient	JJ
cord-256201-vjzfzshh	195	16	nature	nature	NN
cord-256201-vjzfzshh	195	17	of	of	IN
cord-256201-vjzfzshh	195	18	the	the	DT
cord-256201-vjzfzshh	195	19	dsDNA	dsdna	RB
cord-256201-vjzfzshh	195	20	replicative	replicative	JJ
cord-256201-vjzfzshh	195	21	form	form	NN
cord-256201-vjzfzshh	195	22	.	.	.
cord-256201-vjzfzshh	196	1	Cellular	cellular	JJ
cord-256201-vjzfzshh	196	2	Dam	Dam	NNP
cord-256201-vjzfzshh	196	3	methylase	methylase	NN
cord-256201-vjzfzshh	196	4	levels	level	NNS
cord-256201-vjzfzshh	196	5	must	must	MD
cord-256201-vjzfzshh	196	6	be	be	VB
cord-256201-vjzfzshh	196	7	tightly	tightly	RB
cord-256201-vjzfzshh	196	8	regulated	regulate	VBN
cord-256201-vjzfzshh	196	9	,	,	,
cord-256201-vjzfzshh	196	10	because	because	IN
cord-256201-vjzfzshh	196	11	hypo	hypo	NN
cord-256201-vjzfzshh	196	12	-	-	:
cord-256201-vjzfzshh	196	13	and	and	CC
cord-256201-vjzfzshh	196	14	hypermethylation	hypermethylation	NN
cord-256201-vjzfzshh	196	15	can	can	MD
cord-256201-vjzfzshh	196	16	compromise	compromise	VB
cord-256201-vjzfzshh	196	17	the	the	DT
cord-256201-vjzfzshh	196	18	ability	ability	NN
cord-256201-vjzfzshh	196	19	of	of	IN
cord-256201-vjzfzshh	196	20	the	the	DT
cord-256201-vjzfzshh	196	21	MMR	MMR	NNP
cord-256201-vjzfzshh	196	22	system	system	NN
cord-256201-vjzfzshh	196	23	to	to	TO
cord-256201-vjzfzshh	196	24	distinguish	distinguish	VB
cord-256201-vjzfzshh	196	25	between	between	IN
cord-256201-vjzfzshh	196	26	the	the	DT
cord-256201-vjzfzshh	196	27	parental	parental	JJ
cord-256201-vjzfzshh	196	28	and	and	CC
cord-256201-vjzfzshh	196	29	daughter	daughter	NN
cord-256201-vjzfzshh	196	30	DNA	dna	NN
cord-256201-vjzfzshh	196	31	strands	strand	NNS
cord-256201-vjzfzshh	196	32	.	.	.
cord-256201-vjzfzshh	197	1	Showing	show	VBG
cord-256201-vjzfzshh	197	2	this	this	DT
cord-256201-vjzfzshh	197	3	,	,	,
cord-256201-vjzfzshh	197	4	both	both	DT
cord-256201-vjzfzshh	197	5	Dam	Dam	NNP
cord-256201-vjzfzshh	197	6	deficiency	deficiency	NN
cord-256201-vjzfzshh	197	7	(	(	-LRB-
cord-256201-vjzfzshh	197	8	Bale	Bale	NNP
cord-256201-vjzfzshh	197	9	,	,	,
cord-256201-vjzfzshh	197	10	d'Alarcao	d'Alarcao	NNP
cord-256201-vjzfzshh	197	11	,	,	,
cord-256201-vjzfzshh	197	12	and	and	CC
cord-256201-vjzfzshh	197	13	Marinus	Marinus	NNP
cord-256201-vjzfzshh	197	14	1979	1979	CD
cord-256201-vjzfzshh	197	15	;	;	:
cord-256201-vjzfzshh	197	16	Marinus	Marinus	NNP
cord-256201-vjzfzshh	197	17	2010	2010	CD
cord-256201-vjzfzshh	197	18	)	)	-RRB-
cord-256201-vjzfzshh	197	19	and	and	CC
cord-256201-vjzfzshh	197	20	overexpression	overexpression	NN
cord-256201-vjzfzshh	197	21	(	(	-LRB-
cord-256201-vjzfzshh	197	22	Pukkila	Pukkila	NNP
cord-256201-vjzfzshh	197	23	et	et	FW
cord-256201-vjzfzshh	197	24	al	al	NNP
cord-256201-vjzfzshh	197	25	.	.	NNP
cord-256201-vjzfzshh	197	26	1983	1983	CD
cord-256201-vjzfzshh	197	27	;	;	:
cord-256201-vjzfzshh	197	28	McClelland	McClelland	NNP
cord-256201-vjzfzshh	197	29	1984	1984	CD
cord-256201-vjzfzshh	197	30	)	)	-RRB-
cord-256201-vjzfzshh	197	31	have	have	VBP
cord-256201-vjzfzshh	197	32	been	be	VBN
cord-256201-vjzfzshh	197	33	found	find	VBN
cord-256201-vjzfzshh	197	34	to	to	TO
cord-256201-vjzfzshh	197	35	produce	produce	VB
cord-256201-vjzfzshh	197	36	mutator	mutator	NN
cord-256201-vjzfzshh	197	37	phenotypes	phenotype	NNS
cord-256201-vjzfzshh	197	38	in	in	IN
cord-256201-vjzfzshh	197	39	E.	E.	NNP
cord-256201-vjzfzshh	197	40	coli	coli	NNS
cord-256201-vjzfzshh	197	41	.	.	.
cord-256201-vjzfzshh	198	1	It	-PRON-	PRP
cord-256201-vjzfzshh	198	2	is	be	VBZ
cord-256201-vjzfzshh	198	3	possible	possible	JJ
cord-256201-vjzfzshh	198	4	that	that	IN
cord-256201-vjzfzshh	198	5	Dam	dam	JJ
cord-256201-vjzfzshh	198	6	methylation	methylation	NN
cord-256201-vjzfzshh	198	7	levels	level	NNS
cord-256201-vjzfzshh	198	8	which	which	WDT
cord-256201-vjzfzshh	198	9	are	be	VBP
cord-256201-vjzfzshh	198	10	optimal	optimal	JJ
cord-256201-vjzfzshh	198	11	for	for	IN
cord-256201-vjzfzshh	198	12	the	the	DT
cord-256201-vjzfzshh	198	13	host	host	NN
cord-256201-vjzfzshh	198	14	are	be	VBP
cord-256201-vjzfzshh	198	15	too	too	RB
cord-256201-vjzfzshh	198	16	low	low	JJ
cord-256201-vjzfzshh	198	17	for	for	IN
cord-256201-vjzfzshh	198	18	the	the	DT
cord-256201-vjzfzshh	198	19	phage	phage	NN
cord-256201-vjzfzshh	198	20	,	,	,
cord-256201-vjzfzshh	198	21	due	due	IN
cord-256201-vjzfzshh	198	22	to	to	IN
cord-256201-vjzfzshh	198	23	its	-PRON-	PRP$
cord-256201-vjzfzshh	198	24	fastest	fast	JJS
cord-256201-vjzfzshh	198	25	replication	replication	NN
cord-256201-vjzfzshh	198	26	.	.	.
cord-256201-vjzfzshh	199	1	This	this	DT
cord-256201-vjzfzshh	199	2	could	could	MD
cord-256201-vjzfzshh	199	3	be	be	VB
cord-256201-vjzfzshh	199	4	tested	test	VBN
cord-256201-vjzfzshh	199	5	in	in	IN
cord-256201-vjzfzshh	199	6	future	future	JJ
cord-256201-vjzfzshh	199	7	work	work	NN
cord-256201-vjzfzshh	199	8	by	by	IN
cord-256201-vjzfzshh	199	9	infecting	infect	VBG
cord-256201-vjzfzshh	199	10	Dam	Dam	NNP
cord-256201-vjzfzshh	199	11	-	-	HYPH
cord-256201-vjzfzshh	199	12	overexpressing	overexpresse	VBG
cord-256201-vjzfzshh	199	13	E.	E.	NNP
cord-256201-vjzfzshh	199	14	coli	coli	NNS
cord-256201-vjzfzshh	199	15	C	c	NN
cord-256201-vjzfzshh	199	16	mutants	mutant	NNS
cord-256201-vjzfzshh	199	17	with	with	IN
cord-256201-vjzfzshh	199	18	the	the	DT
cord-256201-vjzfzshh	199	19	20GATC	20gatc	CD
cord-256201-vjzfzshh	199	20	phage	phage	NN
cord-256201-vjzfzshh	199	21	and	and	CC
cord-256201-vjzfzshh	199	22	determining	determine	VBG
cord-256201-vjzfzshh	199	23	phage	phage	NN
cord-256201-vjzfzshh	199	24	DNA	dna	NN
cord-256201-vjzfzshh	199	25	methylation	methylation	NN
cord-256201-vjzfzshh	199	26	levels	level	NNS
cord-256201-vjzfzshh	199	27	and	and	CC
cord-256201-vjzfzshh	199	28	mutation	mutation	NN
cord-256201-vjzfzshh	199	29	rates	rate	NNS
cord-256201-vjzfzshh	199	30	.	.	.
cord-256201-vjzfzshh	200	1	Assuming	assume	VBG
cord-256201-vjzfzshh	200	2	that	that	IN
cord-256201-vjzfzshh	200	3	the	the	DT
cord-256201-vjzfzshh	200	4	MMR	MMR	NNP
cord-256201-vjzfzshh	200	5	system	system	NN
cord-256201-vjzfzshh	200	6	can	can	MD
cord-256201-vjzfzshh	200	7	use	use	VB
cord-256201-vjzfzshh	200	8	GATC	GATC	NNP
cord-256201-vjzfzshh	200	9	sites	site	NNS
cord-256201-vjzfzshh	200	10	at	at	IN
cord-256201-vjzfzshh	200	11	a	a	DT
cord-256201-vjzfzshh	200	12	distance	distance	NN
cord-256201-vjzfzshh	200	13	of	of	IN
cord-256201-vjzfzshh	200	14	up	up	IN
cord-256201-vjzfzshh	200	15	to	to	TO
cord-256201-vjzfzshh	200	16	1	1	CD
cord-256201-vjzfzshh	200	17	kb	kb	NNS
cord-256201-vjzfzshh	200	18	from	from	IN
cord-256201-vjzfzshh	200	19	the	the	DT
cord-256201-vjzfzshh	200	20	mismatch	mismatch	NN
cord-256201-vjzfzshh	200	21	,	,	,
cord-256201-vjzfzshh	200	22	for	for	IN
cord-256201-vjzfzshh	200	23	a	a	DT
cord-256201-vjzfzshh	200	24	DNA	dna	NN
cord-256201-vjzfzshh	200	25	showing	show	VBG
cord-256201-vjzfzshh	200	26	the	the	DT
cord-256201-vjzfzshh	200	27	randomly	randomly	RB
cord-256201-vjzfzshh	200	28	expected	expect	VBN
cord-256201-vjzfzshh	200	29	density	density	NN
cord-256201-vjzfzshh	200	30	of	of	IN
cord-256201-vjzfzshh	200	31	GATCs	GATCs	NNP
cord-256201-vjzfzshh	200	32	,	,	,
cord-256201-vjzfzshh	200	33	there	there	EX
cord-256201-vjzfzshh	200	34	should	should	MD
cord-256201-vjzfzshh	200	35	be	be	VB
cord-256201-vjzfzshh	200	36	approximately	approximately	RB
cord-256201-vjzfzshh	200	37	four	four	CD
cord-256201-vjzfzshh	200	38	such	such	JJ
cord-256201-vjzfzshh	200	39	sites	site	NNS
cord-256201-vjzfzshh	200	40	available	available	JJ
cord-256201-vjzfzshh	200	41	for	for	IN
cord-256201-vjzfzshh	200	42	each	each	DT
cord-256201-vjzfzshh	200	43	mismatch	mismatch	NN
cord-256201-vjzfzshh	200	44	.	.	.
cord-256201-vjzfzshh	201	1	For	for	IN
cord-256201-vjzfzshh	201	2	a	a	DT
cord-256201-vjzfzshh	201	3	50	50	CD
cord-256201-vjzfzshh	201	4	per	per	IN
cord-256201-vjzfzshh	201	5	cent	cent	NN
cord-256201-vjzfzshh	201	6	methylation	methylation	NN
cord-256201-vjzfzshh	201	7	efficiency	efficiency	NN
cord-256201-vjzfzshh	201	8	,	,	,
cord-256201-vjzfzshh	201	9	the	the	DT
cord-256201-vjzfzshh	201	10	fraction	fraction	NN
cord-256201-vjzfzshh	201	11	of	of	IN
cord-256201-vjzfzshh	201	12	non	non	JJ
cord-256201-vjzfzshh	201	13	-	-	JJ
cord-256201-vjzfzshh	201	14	reparable	reparable	JJ
cord-256201-vjzfzshh	201	15	mismatches	mismatch	NNS
cord-256201-vjzfzshh	201	16	would	would	MD
cord-256201-vjzfzshh	201	17	thus	thus	RB
cord-256201-vjzfzshh	201	18	be	be	VB
cord-256201-vjzfzshh	201	19	on	on	IN
cord-256201-vjzfzshh	201	20	the	the	DT
cord-256201-vjzfzshh	201	21	order	order	NN
cord-256201-vjzfzshh	201	22	of	of	IN
cord-256201-vjzfzshh	201	23	0.5	0.5	CD
cord-256201-vjzfzshh	201	24	4	4	CD
cord-256201-vjzfzshh	201	25	¼	¼	CD
cord-256201-vjzfzshh	201	26	0.06	0.06	CD
cord-256201-vjzfzshh	201	27	,	,	,
cord-256201-vjzfzshh	201	28	implying	imply	VBG
cord-256201-vjzfzshh	201	29	that	that	IN
cord-256201-vjzfzshh	201	30	the	the	DT
cord-256201-vjzfzshh	201	31	maximum	maximum	JJ
cord-256201-vjzfzshh	201	32	mutation	mutation	NN
cord-256201-vjzfzshh	201	33	rate	rate	NN
cord-256201-vjzfzshh	201	34	reduction	reduction	NN
cord-256201-vjzfzshh	201	35	achievable	achievable	JJ
cord-256201-vjzfzshh	201	36	by	by	IN
cord-256201-vjzfzshh	201	37	MMR	MMR	NNP
cord-256201-vjzfzshh	201	38	for	for	IN
cord-256201-vjzfzshh	201	39	this	this	DT
cord-256201-vjzfzshh	201	40	methylation	methylation	NN
cord-256201-vjzfzshh	201	41	efficiency	efficiency	NN
cord-256201-vjzfzshh	201	42	would	would	MD
cord-256201-vjzfzshh	201	43	be	be	VB
cord-256201-vjzfzshh	201	44	1/0.06	1/0.06	NNP
cord-256201-vjzfzshh	201	45	¼	¼	NNP
cord-256201-vjzfzshh	201	46	seventeenfold	seventeenfold	NN
cord-256201-vjzfzshh	201	47	.	.	.
cord-256201-vjzfzshh	202	1	Incomplete	incomplete	JJ
cord-256201-vjzfzshh	202	2	GATC	GATC	NNP
cord-256201-vjzfzshh	202	3	methylation	methylation	NN
cord-256201-vjzfzshh	202	4	can	can	MD
cord-256201-vjzfzshh	202	5	hence	hence	RB
cord-256201-vjzfzshh	202	6	account	account	VB
cord-256201-vjzfzshh	202	7	for	for	IN
cord-256201-vjzfzshh	202	8	the	the	DT
cord-256201-vjzfzshh	202	9	relatively	relatively	RB
cord-256201-vjzfzshh	202	10	limited	limited	JJ
cord-256201-vjzfzshh	202	11	efficacy	efficacy	NN
cord-256201-vjzfzshh	202	12	of	of	IN
cord-256201-vjzfzshh	202	13	MMR	MMR	NNP
cord-256201-vjzfzshh	202	14	in	in	IN
cord-256201-vjzfzshh	202	15	/X174	/X174	NFP
cord-256201-vjzfzshh	202	16	.	.	.
cord-256201-vjzfzshh	203	1	We	-PRON-	PRP
cord-256201-vjzfzshh	203	2	note	note	VBP
cord-256201-vjzfzshh	203	3	that	that	IN
cord-256201-vjzfzshh	203	4	the	the	DT
cord-256201-vjzfzshh	203	5	fiftyfold	fiftyfold	JJ
cord-256201-vjzfzshh	203	6	mutation	mutation	NN
cord-256201-vjzfzshh	203	7	rate	rate	NN
cord-256201-vjzfzshh	203	8	reduction	reduction	NN
cord-256201-vjzfzshh	203	9	observed	observe	VBN
cord-256201-vjzfzshh	203	10	for	for	IN
cord-256201-vjzfzshh	203	11	the	the	DT
cord-256201-vjzfzshh	203	12	4iGATC	4igatc	CD
cord-256201-vjzfzshh	203	13	virus	virus	NN
cord-256201-vjzfzshh	203	14	could	could	MD
cord-256201-vjzfzshh	203	15	be	be	VB
cord-256201-vjzfzshh	203	16	achieved	achieve	VBN
cord-256201-vjzfzshh	203	17	with	with	IN
cord-256201-vjzfzshh	203	18	63	63	CD
cord-256201-vjzfzshh	203	19	per	per	IN
cord-256201-vjzfzshh	203	20	cent	cent	NN
cord-256201-vjzfzshh	203	21	methylation	methylation	NN
cord-256201-vjzfzshh	203	22	,	,	,
cord-256201-vjzfzshh	203	23	a	a	DT
cord-256201-vjzfzshh	203	24	value	value	NN
cord-256201-vjzfzshh	203	25	experimentally	experimentally	RB
cord-256201-vjzfzshh	203	26	undistinguishable	undistinguishable	JJ
cord-256201-vjzfzshh	203	27	from	from	IN
cord-256201-vjzfzshh	203	28	the	the	DT
cord-256201-vjzfzshh	203	29	50	50	CD
cord-256201-vjzfzshh	203	30	per	per	NN
cord-256201-vjzfzshh	203	31	cent	cent	NN
cord-256201-vjzfzshh	203	32	assumed	assume	VBN
cord-256201-vjzfzshh	203	33	above	above	IN
cord-256201-vjzfzshh	203	34	given	give	VBN
cord-256201-vjzfzshh	203	35	that	that	IN
cord-256201-vjzfzshh	203	36	we	-PRON-	PRP
cord-256201-vjzfzshh	203	37	could	could	MD
cord-256201-vjzfzshh	203	38	not	not	RB
cord-256201-vjzfzshh	203	39	finely	finely	RB
cord-256201-vjzfzshh	203	40	quantify	quantify	VB
cord-256201-vjzfzshh	203	41	the	the	DT
cord-256201-vjzfzshh	203	42	fraction	fraction	NN
cord-256201-vjzfzshh	203	43	of	of	IN
cord-256201-vjzfzshh	203	44	methylated	methylated	JJ
cord-256201-vjzfzshh	203	45	DNA	dna	NN
cord-256201-vjzfzshh	203	46	.	.	.
cord-256201-vjzfzshh	204	1	However	however	RB
cord-256201-vjzfzshh	204	2	,	,	,
cord-256201-vjzfzshh	204	3	for	for	IN
cord-256201-vjzfzshh	204	4	some	some	DT
cord-256201-vjzfzshh	204	5	GATCs	GATCs	NNPS
cord-256201-vjzfzshh	204	6	,	,	,
cord-256201-vjzfzshh	204	7	the	the	DT
cord-256201-vjzfzshh	204	8	efficacy	efficacy	NN
cord-256201-vjzfzshh	204	9	of	of	IN
cord-256201-vjzfzshh	204	10	MMR	MMR	NNP
cord-256201-vjzfzshh	204	11	was	be	VBD
cord-256201-vjzfzshh	204	12	clearly	clearly	RB
cord-256201-vjzfzshh	204	13	below	below	IN
cord-256201-vjzfzshh	204	14	the	the	DT
cord-256201-vjzfzshh	204	15	upper	upper	JJ
cord-256201-vjzfzshh	204	16	-	-	HYPH
cord-256201-vjzfzshh	204	17	limit	limit	NN
cord-256201-vjzfzshh	204	18	imposed	impose	VBN
cord-256201-vjzfzshh	204	19	by	by	IN
cord-256201-vjzfzshh	204	20	under	under	NN
cord-256201-vjzfzshh	204	21	-	-	HYPH
cord-256201-vjzfzshh	204	22	methylation	methylation	NN
cord-256201-vjzfzshh	204	23	,	,	,
cord-256201-vjzfzshh	204	24	since	since	IN
cord-256201-vjzfzshh	204	25	the	the	DT
cord-256201-vjzfzshh	204	26	4GATC	4gatc	CD
cord-256201-vjzfzshh	204	27	and	and	CC
cord-256201-vjzfzshh	204	28	A3940G	A3940G	NNP
cord-256201-vjzfzshh	204	29	/	/	SYM
cord-256201-vjzfzshh	204	30	T3943C	T3943C	NNP
cord-256201-vjzfzshh	204	31	viruses	virus	NNS
cord-256201-vjzfzshh	204	32	showed	show	VBD
cord-256201-vjzfzshh	204	33	no	no	DT
cord-256201-vjzfzshh	204	34	change	change	NN
cord-256201-vjzfzshh	204	35	in	in	IN
cord-256201-vjzfzshh	204	36	mutation	mutation	NN
cord-256201-vjzfzshh	204	37	rate	rate	NN
cord-256201-vjzfzshh	204	38	at	at	RB
cord-256201-vjzfzshh	204	39	all	all	RB
cord-256201-vjzfzshh	204	40	.	.	.
cord-256201-vjzfzshh	205	1	Our	-PRON-	PRP$
cord-256201-vjzfzshh	205	2	results	result	NNS
cord-256201-vjzfzshh	205	3	indicate	indicate	VBP
cord-256201-vjzfzshh	205	4	that	that	IN
cord-256201-vjzfzshh	205	5	intergenic	intergenic	JJ
cord-256201-vjzfzshh	205	6	GATCs	GATCs	NNPS
cord-256201-vjzfzshh	205	7	tended	tend	VBD
cord-256201-vjzfzshh	205	8	to	to	TO
cord-256201-vjzfzshh	205	9	have	have	VB
cord-256201-vjzfzshh	205	10	stronger	strong	JJR
cord-256201-vjzfzshh	205	11	effects	effect	NNS
cord-256201-vjzfzshh	205	12	than	than	IN
cord-256201-vjzfzshh	205	13	those	those	DT
cord-256201-vjzfzshh	205	14	located	locate	VBN
cord-256201-vjzfzshh	205	15	in	in	IN
cord-256201-vjzfzshh	205	16	protein-	protein-	JJ
cord-256201-vjzfzshh	205	17	Table	table	NN
cord-256201-vjzfzshh	205	18	2	2	CD
cord-256201-vjzfzshh	205	19	for	for	IN
cord-256201-vjzfzshh	205	20	details	detail	NNS
cord-256201-vjzfzshh	205	21	.	.	.
cord-256201-vjzfzshh	206	1	coding	code	VBG
cord-256201-vjzfzshh	206	2	regions	region	NNS
cord-256201-vjzfzshh	206	3	,	,	,
cord-256201-vjzfzshh	206	4	suggesting	suggest	VBG
cord-256201-vjzfzshh	206	5	other	other	JJ
cord-256201-vjzfzshh	206	6	factors	factor	NNS
cord-256201-vjzfzshh	206	7	curtailing	curtail	VBG
cord-256201-vjzfzshh	206	8	MMR	MMR	NNP
cord-256201-vjzfzshh	206	9	efficiency	efficiency	NN
cord-256201-vjzfzshh	206	10	such	such	JJ
cord-256201-vjzfzshh	206	11	as	as	IN
cord-256201-vjzfzshh	206	12	steric	steric	JJ
cord-256201-vjzfzshh	206	13	availability	availability	NN
cord-256201-vjzfzshh	206	14	to	to	IN
cord-256201-vjzfzshh	206	15	MutH.	MutH.	.
cord-256201-vjzfzshh	207	1	As	as	IN
cord-256201-vjzfzshh	207	2	we	-PRON-	PRP
cord-256201-vjzfzshh	207	3	have	have	VBP
cord-256201-vjzfzshh	207	4	shown	show	VBN
cord-256201-vjzfzshh	207	5	,	,	,
cord-256201-vjzfzshh	207	6	though	though	RB
cord-256201-vjzfzshh	207	7	,	,	,
cord-256201-vjzfzshh	207	8	even	even	RB
cord-256201-vjzfzshh	207	9	two	two	CD
cord-256201-vjzfzshh	207	10	extremely	extremely	RB
cord-256201-vjzfzshh	207	11	close	close	JJ
cord-256201-vjzfzshh	207	12	GATCs	gatc	NNS
cord-256201-vjzfzshh	207	13	can	can	MD
cord-256201-vjzfzshh	207	14	have	have	VB
cord-256201-vjzfzshh	207	15	very	very	RB
cord-256201-vjzfzshh	207	16	different	different	JJ
cord-256201-vjzfzshh	207	17	effects	effect	NNS
cord-256201-vjzfzshh	207	18	on	on	IN
cord-256201-vjzfzshh	207	19	mutation	mutation	NN
cord-256201-vjzfzshh	207	20	rate	rate	NN
cord-256201-vjzfzshh	207	21	,	,	,
cord-256201-vjzfzshh	207	22	and	and	CC
cord-256201-vjzfzshh	207	23	we	-PRON-	PRP
cord-256201-vjzfzshh	207	24	lack	lack	VBP
cord-256201-vjzfzshh	207	25	a	a	DT
cord-256201-vjzfzshh	207	26	model	model	NN
cord-256201-vjzfzshh	207	27	for	for	IN
cord-256201-vjzfzshh	207	28	explaining	explain	VBG
cord-256201-vjzfzshh	207	29	these	these	DT
cord-256201-vjzfzshh	207	30	differences	difference	NNS
cord-256201-vjzfzshh	207	31	.	.	.
cord-256201-vjzfzshh	208	1	The	the	DT
cord-256201-vjzfzshh	208	2	region	region	NN
cord-256201-vjzfzshh	208	3	in	in	IN
cord-256201-vjzfzshh	208	4	which	which	WDT
cord-256201-vjzfzshh	208	5	the	the	DT
cord-256201-vjzfzshh	208	6	single	single	JJ
cord-256201-vjzfzshh	208	7	intergenic	intergenic	JJ
cord-256201-vjzfzshh	208	8	GATCs	GATCs	NNPS
cord-256201-vjzfzshh	208	9	were	be	VBD
cord-256201-vjzfzshh	208	10	placed	place	VBN
cord-256201-vjzfzshh	208	11	contains	contain	VBZ
cord-256201-vjzfzshh	208	12	the	the	DT
cord-256201-vjzfzshh	208	13	A	A	NNP
cord-256201-vjzfzshh	208	14	promoter	promoter	NN
cord-256201-vjzfzshh	208	15	and	and	CC
cord-256201-vjzfzshh	208	16	the	the	DT
cord-256201-vjzfzshh	208	17	H	H	NNP
cord-256201-vjzfzshh	208	18	terminator	terminator	NN
cord-256201-vjzfzshh	208	19	.	.	.
cord-256201-vjzfzshh	209	1	The	the	DT
cord-256201-vjzfzshh	209	2	C3934G	C3934G	NNP
cord-256201-vjzfzshh	209	3	/	/	SYM
cord-256201-vjzfzshh	209	4	C3935A	C3935A	NNP
cord-256201-vjzfzshh	209	5	substitution	substitution	NN
cord-256201-vjzfzshh	209	6	,	,	,
cord-256201-vjzfzshh	209	7	which	which	WDT
cord-256201-vjzfzshh	209	8	had	have	VBD
cord-256201-vjzfzshh	209	9	the	the	DT
cord-256201-vjzfzshh	209	10	strongest	strong	JJS
cord-256201-vjzfzshh	209	11	effect	effect	NN
cord-256201-vjzfzshh	209	12	on	on	IN
cord-256201-vjzfzshh	209	13	mutation	mutation	NN
cord-256201-vjzfzshh	209	14	rate	rate	NN
cord-256201-vjzfzshh	209	15	,	,	,
cord-256201-vjzfzshh	209	16	was	be	VBD
cord-256201-vjzfzshh	209	17	located	locate	VBN
cord-256201-vjzfzshh	209	18	farthest	farthest	RBS
cord-256201-vjzfzshh	209	19	away	away	RB
cord-256201-vjzfzshh	209	20	from	from	IN
cord-256201-vjzfzshh	209	21	the	the	DT
cord-256201-vjzfzshh	209	22	A	A	NNP
cord-256201-vjzfzshh	209	23	promoter	promoter	NN
cord-256201-vjzfzshh	209	24	.	.	.
cord-256201-vjzfzshh	210	1	We	-PRON-	PRP
cord-256201-vjzfzshh	210	2	can	can	MD
cord-256201-vjzfzshh	210	3	speculate	speculate	VB
cord-256201-vjzfzshh	210	4	that	that	IN
cord-256201-vjzfzshh	210	5	,	,	,
cord-256201-vjzfzshh	210	6	if	if	IN
cord-256201-vjzfzshh	210	7	steric	steric	JJ
cord-256201-vjzfzshh	210	8	availability	availability	NN
cord-256201-vjzfzshh	210	9	of	of	IN
cord-256201-vjzfzshh	210	10	the	the	DT
cord-256201-vjzfzshh	210	11	GATC	GATC	NNP
cord-256201-vjzfzshh	210	12	motif	motif	NN
cord-256201-vjzfzshh	210	13	to	to	IN
cord-256201-vjzfzshh	210	14	MutH	MutH	NNP
cord-256201-vjzfzshh	210	15	was	be	VBD
cord-256201-vjzfzshh	210	16	limited	limit	VBN
cord-256201-vjzfzshh	210	17	by	by	IN
cord-256201-vjzfzshh	210	18	the	the	DT
cord-256201-vjzfzshh	210	19	transcription	transcription	NN
cord-256201-vjzfzshh	210	20	machinery	machinery	NN
cord-256201-vjzfzshh	210	21	,	,	,
cord-256201-vjzfzshh	210	22	a	a	DT
cord-256201-vjzfzshh	210	23	more	more	RBR
cord-256201-vjzfzshh	210	24	distal	distal	JJ
cord-256201-vjzfzshh	210	25	positioning	positioning	NN
cord-256201-vjzfzshh	210	26	from	from	IN
cord-256201-vjzfzshh	210	27	actively	actively	RB
cord-256201-vjzfzshh	210	28	transcribed	transcribe	VBN
cord-256201-vjzfzshh	210	29	regions	region	NNS
cord-256201-vjzfzshh	210	30	may	may	MD
cord-256201-vjzfzshh	210	31	allow	allow	VB
cord-256201-vjzfzshh	210	32	for	for	IN
cord-256201-vjzfzshh	210	33	more	more	RBR
cord-256201-vjzfzshh	210	34	efficient	efficient	JJ
cord-256201-vjzfzshh	210	35	MMR	MMR	NNP
cord-256201-vjzfzshh	210	36	.	.	.
cord-256201-vjzfzshh	211	1	However	however	RB
cord-256201-vjzfzshh	211	2	,	,	,
cord-256201-vjzfzshh	211	3	the	the	DT
cord-256201-vjzfzshh	211	4	A3963	A3963	NNP
cord-256201-vjzfzshh	211	5	G	G	NNP
cord-256201-vjzfzshh	211	6	and	and	CC
cord-256201-vjzfzshh	211	7	A3940G	A3940G	NNP
cord-256201-vjzfzshh	211	8	/	/	SYM
cord-256201-vjzfzshh	211	9	T3943C	T3943C	NNP
cord-256201-vjzfzshh	211	10	substitutions	substitution	NNS
cord-256201-vjzfzshh	211	11	were	be	VBD
cord-256201-vjzfzshh	211	12	located	locate	VBN
cord-256201-vjzfzshh	211	13	approximately	approximately	RB
cord-256201-vjzfzshh	211	14	at	at	IN
cord-256201-vjzfzshh	211	15	the	the	DT
cord-256201-vjzfzshh	211	16	same	same	JJ
cord-256201-vjzfzshh	211	17	distance	distance	NN
cord-256201-vjzfzshh	211	18	of	of	IN
cord-256201-vjzfzshh	211	19	the	the	DT
cord-256201-vjzfzshh	211	20	A	A	NNP
cord-256201-vjzfzshh	211	21	promoter	promoter	NN
cord-256201-vjzfzshh	211	22	.	.	.
cord-256201-vjzfzshh	212	1	A3940	A3940	NNP
cord-256201-vjzfzshh	212	2	G	g	NN
cord-256201-vjzfzshh	213	1	/T3943C	/T3943C	NNP
cord-256201-vjzfzshh	213	2	was	be	VBD
cord-256201-vjzfzshh	213	3	upstream	upstream	JJ
cord-256201-vjzfzshh	213	4	of	of	IN
cord-256201-vjzfzshh	213	5	the	the	DT
cord-256201-vjzfzshh	213	6	promoter	promoter	NN
cord-256201-vjzfzshh	213	7	,	,	,
cord-256201-vjzfzshh	213	8	whereas	whereas	IN
cord-256201-vjzfzshh	213	9	A3963	A3963	NNP
cord-256201-vjzfzshh	213	10	G	G	NNP
cord-256201-vjzfzshh	213	11	was	be	VBD
cord-256201-vjzfzshh	213	12	downstream	downstream	JJ
cord-256201-vjzfzshh	213	13	of	of	IN
cord-256201-vjzfzshh	213	14	the	the	DT
cord-256201-vjzfzshh	213	15	promoter	promoter	NN
cord-256201-vjzfzshh	213	16	and	and	CC
cord-256201-vjzfzshh	213	17	in	in	IN
cord-256201-vjzfzshh	213	18	a	a	DT
cord-256201-vjzfzshh	213	19	palindromic	palindromic	JJ
cord-256201-vjzfzshh	213	20	region	region	NN
cord-256201-vjzfzshh	213	21	with	with	IN
cord-256201-vjzfzshh	213	22	a	a	DT
cord-256201-vjzfzshh	213	23	relative	relative	JJ
cord-256201-vjzfzshh	213	24	high	high	JJ
cord-256201-vjzfzshh	213	25	GþC	gþc	NN
cord-256201-vjzfzshh	213	26	content	content	NN
cord-256201-vjzfzshh	213	27	.	.	.
cord-256201-vjzfzshh	214	1	As	as	IN
cord-256201-vjzfzshh	214	2	suggested	suggest	VBN
cord-256201-vjzfzshh	214	3	previously	previously	RB
cord-256201-vjzfzshh	214	4	,	,	,
cord-256201-vjzfzshh	214	5	mismatch	mismatch	NN
cord-256201-vjzfzshh	214	6	recognition	recognition	NN
cord-256201-vjzfzshh	214	7	may	may	MD
cord-256201-vjzfzshh	214	8	depend	depend	VB
cord-256201-vjzfzshh	214	9	also	also	RB
cord-256201-vjzfzshh	214	10	on	on	IN
cord-256201-vjzfzshh	214	11	sequence	sequence	NN
cord-256201-vjzfzshh	214	12	context	context	NN
cord-256201-vjzfzshh	214	13	,	,	,
cord-256201-vjzfzshh	214	14	increasing	increase	VBG
cord-256201-vjzfzshh	214	15	its	-PRON-	PRP$
cord-256201-vjzfzshh	214	16	efficiency	efficiency	NN
cord-256201-vjzfzshh	214	17	in	in	IN
cord-256201-vjzfzshh	214	18	regions	region	NNS
cord-256201-vjzfzshh	214	19	with	with	IN
cord-256201-vjzfzshh	214	20	higher	high	JJR
cord-256201-vjzfzshh	214	21	GC	GC	NNP
cord-256201-vjzfzshh	214	22	content	content	NN
cord-256201-vjzfzshh	214	23	(	(	-LRB-
cord-256201-vjzfzshh	214	24	Jones	Jones	NNP
cord-256201-vjzfzshh	214	25	,	,	,
cord-256201-vjzfzshh	214	26	Wagner	Wagner	NNP
cord-256201-vjzfzshh	214	27	,	,	,
cord-256201-vjzfzshh	214	28	and	and	CC
cord-256201-vjzfzshh	214	29	Radman	Radman	NNP
cord-256201-vjzfzshh	214	30	1987	1987	CD
cord-256201-vjzfzshh	214	31	)	)	-RRB-
cord-256201-vjzfzshh	214	32	.	.	.
cord-256201-vjzfzshh	215	1	Therefore	therefore	RB
cord-256201-vjzfzshh	215	2	,	,	,
cord-256201-vjzfzshh	215	3	our	-PRON-	PRP$
cord-256201-vjzfzshh	215	4	results	result	NNS
cord-256201-vjzfzshh	215	5	suggest	suggest	VBP
cord-256201-vjzfzshh	215	6	that	that	IN
cord-256201-vjzfzshh	215	7	evolutionary	evolutionary	JJ
cord-256201-vjzfzshh	215	8	optimization	optimization	NN
cord-256201-vjzfzshh	215	9	of	of	IN
cord-256201-vjzfzshh	215	10	the	the	DT
cord-256201-vjzfzshh	215	11	mutation	mutation	NN
cord-256201-vjzfzshh	215	12	rate	rate	NN
cord-256201-vjzfzshh	215	13	may	may	MD
cord-256201-vjzfzshh	215	14	not	not	RB
cord-256201-vjzfzshh	215	15	be	be	VB
cord-256201-vjzfzshh	215	16	the	the	DT
cord-256201-vjzfzshh	215	17	sole	sole	JJ
cord-256201-vjzfzshh	215	18	factor	factor	NN
cord-256201-vjzfzshh	215	19	driving	drive	VBG
cord-256201-vjzfzshh	215	20	GATC	GATC	NNP
cord-256201-vjzfzshh	215	21	avoidance	avoidance	NN
cord-256201-vjzfzshh	215	22	in	in	IN
cord-256201-vjzfzshh	215	23	/X174	/X174	,
cord-256201-vjzfzshh	215	24	or	or	CC
cord-256201-vjzfzshh	215	25	other	other	JJ
cord-256201-vjzfzshh	215	26	enterobacteriophages	enterobacteriophage	NNS
cord-256201-vjzfzshh	215	27	,	,	,
cord-256201-vjzfzshh	215	28	since	since	IN
cord-256201-vjzfzshh	215	29	we	-PRON-	PRP
cord-256201-vjzfzshh	215	30	found	find	VBD
cord-256201-vjzfzshh	215	31	that	that	IN
cord-256201-vjzfzshh	215	32	some	some	DT
cord-256201-vjzfzshh	215	33	GATCs	GATCs	NNPS
cord-256201-vjzfzshh	215	34	had	have	VBD
cord-256201-vjzfzshh	215	35	no	no	DT
cord-256201-vjzfzshh	215	36	effect	effect	NN
cord-256201-vjzfzshh	215	37	on	on	IN
cord-256201-vjzfzshh	215	38	the	the	DT
cord-256201-vjzfzshh	215	39	viral	viral	JJ
cord-256201-vjzfzshh	215	40	mutation	mutation	NN
cord-256201-vjzfzshh	215	41	rate	rate	NN
cord-256201-vjzfzshh	215	42	yet	yet	CC
cord-256201-vjzfzshh	215	43	are	be	VBP
cord-256201-vjzfzshh	215	44	also	also	RB
cord-256201-vjzfzshh	215	45	absent	absent	JJ
cord-256201-vjzfzshh	215	46	from	from	IN
cord-256201-vjzfzshh	215	47	the	the	DT
cord-256201-vjzfzshh	215	48	WT	WT	NNP
cord-256201-vjzfzshh	215	49	/X174	/X174	NNP
cord-256201-vjzfzshh	215	50	genome	genome	NN
cord-256201-vjzfzshh	215	51	.	.	.
cord-256201-vjzfzshh	216	1	Mutation	mutation	NN
cord-256201-vjzfzshh	216	2	rate	rate	NN
cord-256201-vjzfzshh	216	3	elevation	elevation	NN
cord-256201-vjzfzshh	216	4	can	can	MD
cord-256201-vjzfzshh	216	5	confer	confer	VB
cord-256201-vjzfzshh	216	6	faster	fast	JJR
cord-256201-vjzfzshh	216	7	adaptation	adaptation	NN
cord-256201-vjzfzshh	216	8	to	to	IN
cord-256201-vjzfzshh	216	9	new	new	JJ
cord-256201-vjzfzshh	216	10	and	and	CC
cord-256201-vjzfzshh	216	11	stressful	stressful	JJ
cord-256201-vjzfzshh	216	12	environments	environment	NNS
cord-256201-vjzfzshh	216	13	,	,	,
cord-256201-vjzfzshh	216	14	and	and	CC
cord-256201-vjzfzshh	216	15	this	this	DT
cord-256201-vjzfzshh	216	16	has	have	VBZ
cord-256201-vjzfzshh	216	17	been	be	VBN
cord-256201-vjzfzshh	216	18	shown	show	VBN
cord-256201-vjzfzshh	216	19	to	to	TO
cord-256201-vjzfzshh	216	20	promote	promote	VB
cord-256201-vjzfzshh	216	21	the	the	DT
cord-256201-vjzfzshh	216	22	spread	spread	NN
cord-256201-vjzfzshh	216	23	of	of	IN
cord-256201-vjzfzshh	216	24	mutator	mutator	NN
cord-256201-vjzfzshh	216	25	strains	strain	NNS
cord-256201-vjzfzshh	216	26	in	in	IN
cord-256201-vjzfzshh	216	27	bacteria	bacteria	NNS
cord-256201-vjzfzshh	216	28	(	(	-LRB-
cord-256201-vjzfzshh	216	29	LeClerc	LeClerc	NNP
cord-256201-vjzfzshh	216	30	et	et	NNP
cord-256201-vjzfzshh	216	31	al	al	NNP
cord-256201-vjzfzshh	216	32	.	.	.
cord-256201-vjzfzshh	217	1	1996	1996	CD
cord-256201-vjzfzshh	217	2	;	;	:
cord-256201-vjzfzshh	217	3	Sniegowski	Sniegowski	NNP
cord-256201-vjzfzshh	217	4	,	,	,
cord-256201-vjzfzshh	217	5	Gerrish	Gerrish	NNP
cord-256201-vjzfzshh	217	6	,	,	,
cord-256201-vjzfzshh	217	7	and	and	CC
cord-256201-vjzfzshh	217	8	Lenski	Lenski	NNP
cord-256201-vjzfzshh	217	9	1997	1997	CD
cord-256201-vjzfzshh	217	10	;	;	:
cord-256201-vjzfzshh	217	11	Jolivet	Jolivet	NNP
cord-256201-vjzfzshh	217	12	-	-	HYPH
cord-256201-vjzfzshh	217	13	Gougeon	Gougeon	NNP
cord-256201-vjzfzshh	217	14	et	et	NNP
cord-256201-vjzfzshh	217	15	al	al	NNP
cord-256201-vjzfzshh	217	16	.	.	NNP
cord-256201-vjzfzshh	217	17	2011	2011	CD
cord-256201-vjzfzshh	217	18	)	)	-RRB-
cord-256201-vjzfzshh	217	19	.	.	.
cord-256201-vjzfzshh	218	1	Furthermore	furthermore	RB
cord-256201-vjzfzshh	218	2	,	,	,
cord-256201-vjzfzshh	218	3	bacteria	bacteria	NNS
cord-256201-vjzfzshh	218	4	have	have	VBP
cord-256201-vjzfzshh	218	5	evolved	evolve	VBN
cord-256201-vjzfzshh	218	6	the	the	DT
cord-256201-vjzfzshh	218	7	ability	ability	NN
cord-256201-vjzfzshh	218	8	to	to	TO
cord-256201-vjzfzshh	218	9	up	up	RB
cord-256201-vjzfzshh	218	10	-	-	HYPH
cord-256201-vjzfzshh	218	11	regulate	regulate	VB
cord-256201-vjzfzshh	218	12	their	-PRON-	PRP$
cord-256201-vjzfzshh	218	13	mutation	mutation	NN
cord-256201-vjzfzshh	218	14	rates	rate	NNS
cord-256201-vjzfzshh	218	15	in	in	IN
cord-256201-vjzfzshh	218	16	response	response	NN
cord-256201-vjzfzshh	218	17	to	to	IN
cord-256201-vjzfzshh	218	18	stress	stress	NN
cord-256201-vjzfzshh	218	19	by	by	IN
cord-256201-vjzfzshh	218	20	expressing	express	VBG
cord-256201-vjzfzshh	218	21	of	of	IN
cord-256201-vjzfzshh	218	22	error	error	NN
cord-256201-vjzfzshh	218	23	-	-	HYPH
cord-256201-vjzfzshh	218	24	prone	prone	JJ
cord-256201-vjzfzshh	218	25	polymerases	polymerase	NNS
cord-256201-vjzfzshh	218	26	(	(	-LRB-
cord-256201-vjzfzshh	218	27	Rosenberg	Rosenberg	NNP
cord-256201-vjzfzshh	218	28	2001	2001	CD
cord-256201-vjzfzshh	218	29	;	;	:
cord-256201-vjzfzshh	218	30	Galhardo	Galhardo	NNP
cord-256201-vjzfzshh	218	31	,	,	,
cord-256201-vjzfzshh	218	32	Hastings	Hastings	NNP
cord-256201-vjzfzshh	218	33	,	,	,
cord-256201-vjzfzshh	218	34	and	and	CC
cord-256201-vjzfzshh	218	35	Rosenberg	Rosenberg	NNP
cord-256201-vjzfzshh	218	36	2007	2007	CD
cord-256201-vjzfzshh	218	37	)	)	-RRB-
cord-256201-vjzfzshh	218	38	.	.	.
cord-256201-vjzfzshh	219	1	However	however	RB
cord-256201-vjzfzshh	219	2	,	,	,
cord-256201-vjzfzshh	219	3	we	-PRON-	PRP
cord-256201-vjzfzshh	219	4	have	have	VBP
cord-256201-vjzfzshh	219	5	shown	show	VBN
cord-256201-vjzfzshh	219	6	that	that	IN
cord-256201-vjzfzshh	219	7	GATC	GATC	NNP
cord-256201-vjzfzshh	219	8	avoidance	avoidance	NN
cord-256201-vjzfzshh	219	9	does	do	VBZ
cord-256201-vjzfzshh	219	10	not	not	RB
cord-256201-vjzfzshh	219	11	appear	appear	VB
cord-256201-vjzfzshh	219	12	to	to	TO
cord-256201-vjzfzshh	219	13	increase	increase	VB
cord-256201-vjzfzshh	219	14	the	the	DT
cord-256201-vjzfzshh	219	15	/X174	/X174	NFP
cord-256201-vjzfzshh	219	16	mutation	mutation	NN
cord-256201-vjzfzshh	219	17	rate	rate	NN
cord-256201-vjzfzshh	219	18	under	under	IN
cord-256201-vjzfzshh	219	19	stress	stress	NN
cord-256201-vjzfzshh	219	20	conditions	condition	NNS
cord-256201-vjzfzshh	219	21	,	,	,
cord-256201-vjzfzshh	219	22	thus	thus	RB
cord-256201-vjzfzshh	219	23	undermining	undermine	VBG
cord-256201-vjzfzshh	219	24	the	the	DT
cord-256201-vjzfzshh	219	25	potential	potential	JJ
cord-256201-vjzfzshh	219	26	evolutionary	evolutionary	JJ
cord-256201-vjzfzshh	219	27	advantage	advantage	NN
cord-256201-vjzfzshh	219	28	of	of	IN
cord-256201-vjzfzshh	219	29	such	such	JJ
cord-256201-vjzfzshh	219	30	avoidance	avoidance	NN
cord-256201-vjzfzshh	219	31	.	.	.
cord-256201-vjzfzshh	220	1	It	-PRON-	PRP
cord-256201-vjzfzshh	220	2	has	have	VBZ
cord-256201-vjzfzshh	220	3	been	be	VBN
cord-256201-vjzfzshh	220	4	shown	show	VBN
cord-256201-vjzfzshh	220	5	that	that	IN
cord-256201-vjzfzshh	220	6	phage	phage	NN
cord-256201-vjzfzshh	220	7	yields	yield	NNS
cord-256201-vjzfzshh	220	8	tend	tend	VBP
cord-256201-vjzfzshh	220	9	to	to	TO
cord-256201-vjzfzshh	220	10	decrease	decrease	VB
cord-256201-vjzfzshh	220	11	in	in	IN
cord-256201-vjzfzshh	220	12	dam	dam	NN
cord-256201-vjzfzshh	220	13	-mutH	-mutH	:
cord-256201-vjzfzshh	220	14	þ	þ	NN
cord-256201-vjzfzshh	220	15	suggesting	suggest	VBG
cord-256201-vjzfzshh	220	16	that	that	IN
cord-256201-vjzfzshh	220	17	,	,	,
cord-256201-vjzfzshh	220	18	in	in	IN
cord-256201-vjzfzshh	220	19	the	the	DT
cord-256201-vjzfzshh	220	20	absence	absence	NN
cord-256201-vjzfzshh	220	21	of	of	IN
cord-256201-vjzfzshh	220	22	methylation	methylation	NN
cord-256201-vjzfzshh	220	23	,	,	,
cord-256201-vjzfzshh	220	24	MutH	MutH	NNP
cord-256201-vjzfzshh	220	25	cleaves	cleave	VBZ
cord-256201-vjzfzshh	220	26	some	some	DT
cord-256201-vjzfzshh	220	27	GATC	GATC	NNP
cord-256201-vjzfzshh	220	28	sites	site	NNS
cord-256201-vjzfzshh	220	29	non	non	VBP
cord-256201-vjzfzshh	220	30	-	-	JJ
cord-256201-vjzfzshh	220	31	specifically	specifically	RB
cord-256201-vjzfzshh	220	32	and	and	CC
cord-256201-vjzfzshh	220	33	may	may	MD
cord-256201-vjzfzshh	220	34	also	also	RB
cord-256201-vjzfzshh	220	35	interfere	interfere	VB
cord-256201-vjzfzshh	220	36	with	with	IN
cord-256201-vjzfzshh	220	37	other	other	JJ
cord-256201-vjzfzshh	220	38	stages	stage	NNS
cord-256201-vjzfzshh	220	39	of	of	IN
cord-256201-vjzfzshh	220	40	the	the	DT
cord-256201-vjzfzshh	220	41	infection	infection	NN
cord-256201-vjzfzshh	220	42	cycle	cycle	NN
cord-256201-vjzfzshh	220	43	such	such	JJ
cord-256201-vjzfzshh	220	44	as	as	IN
cord-256201-vjzfzshh	220	45	replication	replication	NN
cord-256201-vjzfzshh	220	46	or	or	CC
cord-256201-vjzfzshh	220	47	encapsidation	encapsidation	NN
cord-256201-vjzfzshh	220	48	(	(	-LRB-
cord-256201-vjzfzshh	220	49	Deschavanne	Deschavanne	NNP
cord-256201-vjzfzshh	220	50	and	and	CC
cord-256201-vjzfzshh	220	51	Radman	Radman	NNP
cord-256201-vjzfzshh	220	52	1991	1991	CD
cord-256201-vjzfzshh	220	53	)	)	-RRB-
cord-256201-vjzfzshh	220	54	.	.	.
cord-256201-vjzfzshh	221	1	This	this	DT
cord-256201-vjzfzshh	221	2	would	would	MD
cord-256201-vjzfzshh	221	3	directly	directly	RB
cord-256201-vjzfzshh	221	4	counterselect	counterselect	VB
cord-256201-vjzfzshh	221	5	GATC	GATC	NNP
cord-256201-vjzfzshh	221	6	sequence	sequence	NN
cord-256201-vjzfzshh	221	7	motifs	motif	NNS
cord-256201-vjzfzshh	221	8	in	in	IN
cord-256201-vjzfzshh	221	9	the	the	DT
cord-256201-vjzfzshh	221	10	phage	phage	NN
cord-256201-vjzfzshh	221	11	.	.	.
cord-256201-vjzfzshh	222	1	Although	although	IN
cord-256201-vjzfzshh	222	2	in	in	IN
cord-256201-vjzfzshh	222	3	our	-PRON-	PRP$
cord-256201-vjzfzshh	222	4	experimental	experimental	JJ
cord-256201-vjzfzshh	222	5	setting	setting	NN
cord-256201-vjzfzshh	222	6	,	,	,
cord-256201-vjzfzshh	222	7	we	-PRON-	PRP
cord-256201-vjzfzshh	222	8	did	do	VBD
cord-256201-vjzfzshh	222	9	not	not	RB
cord-256201-vjzfzshh	222	10	detect	detect	VB
cord-256201-vjzfzshh	222	11	a	a	DT
cord-256201-vjzfzshh	222	12	significant	significant	JJ
cord-256201-vjzfzshh	222	13	deleterious	deleterious	JJ
cord-256201-vjzfzshh	222	14	fitness	fitness	NN
cord-256201-vjzfzshh	222	15	effect	effect	NN
cord-256201-vjzfzshh	222	16	associated	associate	VBN
cord-256201-vjzfzshh	222	17	with	with	IN
cord-256201-vjzfzshh	222	18	GATCs	GATCs	NNPS
cord-256201-vjzfzshh	222	19	in	in	IN
cord-256201-vjzfzshh	222	20	the	the	DT
cord-256201-vjzfzshh	222	21	absence	absence	NN
cord-256201-vjzfzshh	222	22	of	of	IN
cord-256201-vjzfzshh	222	23	stress	stress	NN
cord-256201-vjzfzshh	222	24	,	,	,
cord-256201-vjzfzshh	222	25	such	such	JJ
cord-256201-vjzfzshh	222	26	effects	effect	NNS
cord-256201-vjzfzshh	222	27	may	may	MD
cord-256201-vjzfzshh	222	28	potentially	potentially	RB
cord-256201-vjzfzshh	222	29	take	take	VB
cord-256201-vjzfzshh	222	30	place	place	NN
cord-256201-vjzfzshh	222	31	in	in	IN
cord-256201-vjzfzshh	222	32	other	other	JJ
cord-256201-vjzfzshh	222	33	environments	environment	NNS
cord-256201-vjzfzshh	222	34	not	not	RB
cord-256201-vjzfzshh	222	35	assayed	assay	VBN
cord-256201-vjzfzshh	222	36	here	here	RB
cord-256201-vjzfzshh	222	37	.	.	.
cord-256201-vjzfzshh	223	1	Therefore	therefore	RB
cord-256201-vjzfzshh	223	2	,	,	,
cord-256201-vjzfzshh	223	3	the	the	DT
cord-256201-vjzfzshh	223	4	evolutionary	evolutionary	JJ
cord-256201-vjzfzshh	223	5	forces	force	NNS
cord-256201-vjzfzshh	223	6	shaping	shape	VBG
cord-256201-vjzfzshh	223	7	GATC	GATC	NNP
cord-256201-vjzfzshh	223	8	avoidance	avoidance	NN
cord-256201-vjzfzshh	223	9	remain	remain	VBP
cord-256201-vjzfzshh	223	10	unclear	unclear	JJ
cord-256201-vjzfzshh	223	11	,	,	,
cord-256201-vjzfzshh	223	12	and	and	CC
cord-256201-vjzfzshh	223	13	may	may	MD
cord-256201-vjzfzshh	223	14	result	result	VB
cord-256201-vjzfzshh	223	15	from	from	IN
cord-256201-vjzfzshh	223	16	the	the	DT
cord-256201-vjzfzshh	223	17	joint	joint	JJ
cord-256201-vjzfzshh	223	18	action	action	NN
cord-256201-vjzfzshh	223	19	of	of	IN
cord-256201-vjzfzshh	223	20	several	several	JJ
cord-256201-vjzfzshh	223	21	factors	factor	NNS
cord-256201-vjzfzshh	223	22	.	.	.
cord-256201-vjzfzshh	224	1	Interestingly	interestingly	RB
cord-256201-vjzfzshh	224	2	,	,	,
cord-256201-vjzfzshh	224	3	DNA	dna	NN
cord-256201-vjzfzshh	224	4	repair	repair	NN
cord-256201-vjzfzshh	224	5	pathways	pathway	NNS
cord-256201-vjzfzshh	224	6	may	may	MD
cord-256201-vjzfzshh	224	7	also	also	RB
cord-256201-vjzfzshh	224	8	be	be	VB
cord-256201-vjzfzshh	224	9	relevant	relevant	JJ
cord-256201-vjzfzshh	224	10	to	to	IN
cord-256201-vjzfzshh	224	11	virus	virus	NN
cord-256201-vjzfzshh	224	12	-	-	HYPH
cord-256201-vjzfzshh	224	13	host	host	NN
cord-256201-vjzfzshh	224	14	interactions	interaction	NNS
cord-256201-vjzfzshh	224	15	in	in	IN
cord-256201-vjzfzshh	224	16	eukaryotes	eukaryote	NNS
cord-256201-vjzfzshh	224	17	.	.	.
cord-256201-vjzfzshh	225	1	Vertebrate	vertebrate	JJ
cord-256201-vjzfzshh	225	2	DNA	dna	NN
cord-256201-vjzfzshh	225	3	viruses	virus	NNS
cord-256201-vjzfzshh	225	4	have	have	VBP
cord-256201-vjzfzshh	225	5	been	be	VBN
cord-256201-vjzfzshh	225	6	shown	show	VBN
cord-256201-vjzfzshh	225	7	to	to	TO
cord-256201-vjzfzshh	225	8	interact	interact	VB
cord-256201-vjzfzshh	225	9	with	with	IN
cord-256201-vjzfzshh	225	10	the	the	DT
cord-256201-vjzfzshh	225	11	evolutionarily	evolutionarily	RB
cord-256201-vjzfzshh	225	12	conserved	conserve	VBN
cord-256201-vjzfzshh	225	13	DDR	ddr	NN
cord-256201-vjzfzshh	225	14	,	,	,
cord-256201-vjzfzshh	225	15	which	which	WDT
cord-256201-vjzfzshh	225	16	is	be	VBZ
cord-256201-vjzfzshh	225	17	aimed	aim	VBN
cord-256201-vjzfzshh	225	18	at	at	IN
cord-256201-vjzfzshh	225	19	detecting	detect	VBG
cord-256201-vjzfzshh	225	20	lesions	lesion	NNS
cord-256201-vjzfzshh	225	21	in	in	IN
cord-256201-vjzfzshh	225	22	DNA	dna	NN
cord-256201-vjzfzshh	225	23	,	,	,
cord-256201-vjzfzshh	225	24	initiating	initiate	VBG
cord-256201-vjzfzshh	225	25	cell	cell	NN
cord-256201-vjzfzshh	225	26	cycle	cycle	NN
cord-256201-vjzfzshh	225	27	arrest	arrest	NN
cord-256201-vjzfzshh	225	28	,	,	,
cord-256201-vjzfzshh	225	29	and	and	CC
cord-256201-vjzfzshh	225	30	promoting	promote	VBG
cord-256201-vjzfzshh	225	31	repair	repair	NN
cord-256201-vjzfzshh	225	32	.	.	.
cord-256201-vjzfzshh	226	1	For	for	IN
cord-256201-vjzfzshh	226	2	instance	instance	NN
cord-256201-vjzfzshh	226	3	,	,	,
cord-256201-vjzfzshh	226	4	in	in	IN
cord-256201-vjzfzshh	226	5	hepadnaviruses	hepadnavirus	NNS
cord-256201-vjzfzshh	226	6	,	,	,
cord-256201-vjzfzshh	226	7	the	the	DT
cord-256201-vjzfzshh	226	8	synthesis	synthesis	NN
cord-256201-vjzfzshh	226	9	of	of	IN
cord-256201-vjzfzshh	226	10	replication	replication	NN
cord-256201-vjzfzshh	226	11	-	-	HYPH
cord-256201-vjzfzshh	226	12	competent	competent	JJ
cord-256201-vjzfzshh	226	13	covalently	covalently	RB
cord-256201-vjzfzshh	226	14	closed	closed	JJ
cord-256201-vjzfzshh	226	15	circular	circular	JJ
cord-256201-vjzfzshh	226	16	DNA	dna	NN
cord-256201-vjzfzshh	226	17	requires	require	VBZ
cord-256201-vjzfzshh	226	18	the	the	DT
cord-256201-vjzfzshh	226	19	participation	participation	NN
cord-256201-vjzfzshh	226	20	of	of	IN
cord-256201-vjzfzshh	226	21	Ku80	Ku80	NNP
cord-256201-vjzfzshh	226	22	,	,	,
cord-256201-vjzfzshh	226	23	a	a	DT
cord-256201-vjzfzshh	226	24	component	component	NN
cord-256201-vjzfzshh	226	25	of	of	IN
cord-256201-vjzfzshh	226	26	non	non	JJ
cord-256201-vjzfzshh	226	27	-	-	JJ
cord-256201-vjzfzshh	226	28	homologous	homologous	JJ
cord-256201-vjzfzshh	226	29	end	end	NN
cord-256201-vjzfzshh	226	30	joining	join	VBG
cord-256201-vjzfzshh	226	31	DNA	dna	NN
cord-256201-vjzfzshh	226	32	repair	repair	NN
cord-256201-vjzfzshh	226	33	pathway	pathway	NN
cord-256201-vjzfzshh	226	34	(	(	-LRB-
cord-256201-vjzfzshh	226	35	Guo	Guo	NNP
cord-256201-vjzfzshh	226	36	et	et	FW
cord-256201-vjzfzshh	226	37	al	al	NNP
cord-256201-vjzfzshh	226	38	.	.	NNP
cord-256201-vjzfzshh	226	39	2012	2012	CD
cord-256201-vjzfzshh	226	40	)	)	-RRB-
cord-256201-vjzfzshh	226	41	.	.	.
cord-256201-vjzfzshh	227	1	Indeed	indeed	RB
cord-256201-vjzfzshh	227	2	,	,	,
cord-256201-vjzfzshh	227	3	DNA	dna	NN
cord-256201-vjzfzshh	227	4	damage	damage	NN
cord-256201-vjzfzshh	227	5	induction	induction	NN
cord-256201-vjzfzshh	227	6	seems	seem	VBZ
cord-256201-vjzfzshh	227	7	to	to	TO
cord-256201-vjzfzshh	227	8	be	be	VB
cord-256201-vjzfzshh	227	9	a	a	DT
cord-256201-vjzfzshh	227	10	common	common	JJ
cord-256201-vjzfzshh	227	11	feature	feature	NN
cord-256201-vjzfzshh	227	12	of	of	IN
cord-256201-vjzfzshh	227	13	many	many	JJ
cord-256201-vjzfzshh	227	14	DNA	dna	NN
cord-256201-vjzfzshh	227	15	viruses	virus	NNS
cord-256201-vjzfzshh	227	16	including	include	VBG
cord-256201-vjzfzshh	227	17	adenoviruses	adenovirus	NNS
cord-256201-vjzfzshh	227	18	,	,	,
cord-256201-vjzfzshh	227	19	herpesviruses	herpesviruses	NNP
cord-256201-vjzfzshh	227	20	,	,	,
cord-256201-vjzfzshh	227	21	polyomaviruses	polyomaviruse	NNS
cord-256201-vjzfzshh	227	22	,	,	,
cord-256201-vjzfzshh	227	23	and	and	CC
cord-256201-vjzfzshh	227	24	papillomaviruses	papillomaviruse	NNS
cord-256201-vjzfzshh	227	25	(	(	-LRB-
cord-256201-vjzfzshh	227	26	Luftig	Luftig	NNP
cord-256201-vjzfzshh	227	27	2014	2014	CD
cord-256201-vjzfzshh	227	28	)	)	-RRB-
cord-256201-vjzfzshh	227	29	.	.	.
cord-256201-vjzfzshh	228	1	Most	Most	JJS
cord-256201-vjzfzshh	228	2	viruses	virus	NNS
cord-256201-vjzfzshh	228	3	degrade	degrade	VBP
cord-256201-vjzfzshh	228	4	DDR	ddr	NN
cord-256201-vjzfzshh	228	5	components	component	NNS
cord-256201-vjzfzshh	228	6	,	,	,
cord-256201-vjzfzshh	228	7	but	but	CC
cord-256201-vjzfzshh	228	8	DDR	ddr	NN
cord-256201-vjzfzshh	228	9	activation	activation	NN
cord-256201-vjzfzshh	228	10	and	and	CC
cord-256201-vjzfzshh	228	11	recruitment	recruitment	NN
cord-256201-vjzfzshh	228	12	of	of	IN
cord-256201-vjzfzshh	228	13	some	some	DT
cord-256201-vjzfzshh	228	14	of	of	IN
cord-256201-vjzfzshh	228	15	its	-PRON-	PRP$
cord-256201-vjzfzshh	228	16	components	component	NNS
cord-256201-vjzfzshh	228	17	into	into	IN
cord-256201-vjzfzshh	228	18	viral	viral	JJ
cord-256201-vjzfzshh	228	19	replication	replication	NN
cord-256201-vjzfzshh	228	20	centers	center	NNS
cord-256201-vjzfzshh	228	21	is	be	VBZ
cord-256201-vjzfzshh	228	22	also	also	RB
cord-256201-vjzfzshh	228	23	common	common	JJ
cord-256201-vjzfzshh	228	24	.	.	.
cord-256201-vjzfzshh	229	1	However	however	RB
cord-256201-vjzfzshh	229	2	,	,	,
cord-256201-vjzfzshh	229	3	the	the	DT
cord-256201-vjzfzshh	229	4	outcomes	outcome	NNS
cord-256201-vjzfzshh	229	5	of	of	IN
cord-256201-vjzfzshh	229	6	virus	virus	NN
cord-256201-vjzfzshh	229	7	-	-	HYPH
cord-256201-vjzfzshh	229	8	host	host	NN
cord-256201-vjzfzshh	229	9	interactions	interaction	NNS
cord-256201-vjzfzshh	229	10	at	at	IN
cord-256201-vjzfzshh	229	11	the	the	DT
cord-256201-vjzfzshh	229	12	DDR	ddr	NN
cord-256201-vjzfzshh	229	13	level	level	NN
cord-256201-vjzfzshh	229	14	are	be	VBP
cord-256201-vjzfzshh	229	15	still	still	RB
cord-256201-vjzfzshh	229	16	poorly	poorly	RB
cord-256201-vjzfzshh	229	17	understood	understand	VBN
cord-256201-vjzfzshh	229	18	,	,	,
cord-256201-vjzfzshh	229	19	and	and	CC
cord-256201-vjzfzshh	229	20	it	-PRON-	PRP
cord-256201-vjzfzshh	229	21	remains	remain	VBZ
cord-256201-vjzfzshh	229	22	at	at	IN
cord-256201-vjzfzshh	229	23	present	present	JJ
cord-256201-vjzfzshh	229	24	unknown	unknown	NN
cord-256201-vjzfzshh	229	25	whether	whether	IN
cord-256201-vjzfzshh	229	26	DDR	ddr	NN
cord-256201-vjzfzshh	229	27	activation	activation	NN
cord-256201-vjzfzshh	229	28	is	be	VBZ
cord-256201-vjzfzshh	229	29	part	part	NN
cord-256201-vjzfzshh	229	30	of	of	IN
cord-256201-vjzfzshh	229	31	an	an	DT
cord-256201-vjzfzshh	229	32	antiviral	antiviral	JJ
cord-256201-vjzfzshh	229	33	cellular	cellular	JJ
cord-256201-vjzfzshh	229	34	response	response	NN
cord-256201-vjzfzshh	229	35	or	or	CC
cord-256201-vjzfzshh	229	36	is	be	VBZ
cord-256201-vjzfzshh	229	37	exploited	exploit	VBN
cord-256201-vjzfzshh	229	38	by	by	IN
cord-256201-vjzfzshh	229	39	the	the	DT
cord-256201-vjzfzshh	229	40	virus	virus	NN
cord-256201-vjzfzshh	229	41	.	.	.
cord-256201-vjzfzshh	230	1	In	in	IN
cord-256201-vjzfzshh	230	2	any	any	DT
cord-256201-vjzfzshh	230	3	case	case	NN
cord-256201-vjzfzshh	230	4	,	,	,
cord-256201-vjzfzshh	230	5	repair	repair	NN
cord-256201-vjzfzshh	230	6	pathways	pathway	NNS
cord-256201-vjzfzshh	230	7	are	be	VBP
cord-256201-vjzfzshh	230	8	activated	activate	VBN
cord-256201-vjzfzshh	230	9	following	follow	VBG
cord-256201-vjzfzshh	230	10	virus	virus	NN
cord-256201-vjzfzshh	230	11	-	-	HYPH
cord-256201-vjzfzshh	230	12	induced	induce	VBN
cord-256201-vjzfzshh	230	13	DNA	dna	NN
cord-256201-vjzfzshh	230	14	damage	damage	NN
cord-256201-vjzfzshh	230	15	,	,	,
cord-256201-vjzfzshh	230	16	leading	lead	VBG
cord-256201-vjzfzshh	230	17	to	to	IN
cord-256201-vjzfzshh	230	18	the	the	DT
cord-256201-vjzfzshh	230	19	recruitment	recruitment	NN
cord-256201-vjzfzshh	230	20	of	of	IN
cord-256201-vjzfzshh	230	21	error	error	NN
cord-256201-vjzfzshh	230	22	-	-	HYPH
cord-256201-vjzfzshh	230	23	prone	prone	JJ
cord-256201-vjzfzshh	230	24	host	host	NN
cord-256201-vjzfzshh	230	25	polymerases	polymerase	NNS
cord-256201-vjzfzshh	230	26	(	(	-LRB-
cord-256201-vjzfzshh	230	27	Malkova	Malkova	NNP
cord-256201-vjzfzshh	230	28	and	and	CC
cord-256201-vjzfzshh	230	29	Haber	Haber	NNP
cord-256201-vjzfzshh	230	30	2012	2012	CD
cord-256201-vjzfzshh	230	31	)	)	-RRB-
cord-256201-vjzfzshh	230	32	.	.	.
cord-256201-vjzfzshh	231	1	This	this	DT
cord-256201-vjzfzshh	231	2	suggests	suggest	VBZ
cord-256201-vjzfzshh	231	3	that	that	IN
cord-256201-vjzfzshh	231	4	changes	change	NNS
cord-256201-vjzfzshh	231	5	in	in	IN
cord-256201-vjzfzshh	231	6	MMR	MMR	NNP
cord-256201-vjzfzshh	231	7	efficiency	efficiency	NN
cord-256201-vjzfzshh	231	8	following	follow	VBG
cord-256201-vjzfzshh	231	9	infection	infection	NN
cord-256201-vjzfzshh	231	10	may	may	MD
cord-256201-vjzfzshh	231	11	determine	determine	VB
cord-256201-vjzfzshh	231	12	the	the	DT
cord-256201-vjzfzshh	231	13	mutation	mutation	NN
cord-256201-vjzfzshh	231	14	rates	rate	NNS
cord-256201-vjzfzshh	231	15	of	of	IN
cord-256201-vjzfzshh	231	16	some	some	DT
cord-256201-vjzfzshh	231	17	DNA	dna	NN
cord-256201-vjzfzshh	231	18	viruses	virus	NNS
cord-256201-vjzfzshh	231	19	.	.	.
cord-256201-vjzfzshh	232	1	Thymine	Thymine	NNP
cord-256201-vjzfzshh	232	2	Metabolism	Metabolism	NNP
cord-256201-vjzfzshh	232	3	and	and	CC
cord-256201-vjzfzshh	232	4	Thymineless	Thymineless	NNP
cord-256201-vjzfzshh	232	5	Death	Death	NNP
cord-256201-vjzfzshh	232	6	in	in	IN
cord-256201-vjzfzshh	232	7	Prokaryotes	Prokaryotes	NNPS
cord-256201-vjzfzshh	232	8	and	and	CC
cord-256201-vjzfzshh	232	9	Eukaryotes	eukaryote	NNS
cord-256201-vjzfzshh	233	1	The	the	DT
cord-256201-vjzfzshh	233	2	Evolution	Evolution	NNP
cord-256201-vjzfzshh	233	3	of	of	IN
cord-256201-vjzfzshh	233	4	Mutation	Mutation	NNP
cord-256201-vjzfzshh	233	5	Rate	rate	NN
cord-256201-vjzfzshh	233	6	in	in	IN
cord-256201-vjzfzshh	233	7	Finite	finite	JJ
cord-256201-vjzfzshh	233	8	Asexual	Asexual	NNP
cord-256201-vjzfzshh	233	9	Populations	Populations	NNPS
cord-256201-vjzfzshh	233	10	Determinants	Determinants	NNPS
cord-256201-vjzfzshh	233	11	of	of	IN
cord-256201-vjzfzshh	233	12	RNA	RNA	NNP
cord-256201-vjzfzshh	233	13	-	-	HYPH
cord-256201-vjzfzshh	233	14	Dependent	Dependent	NNP
cord-256201-vjzfzshh	233	15	RNA	RNA	NNP
cord-256201-vjzfzshh	233	16	Polymerase	Polymerase	NNP
cord-256201-vjzfzshh	233	17	(	(	-LRB-
cord-256201-vjzfzshh	233	18	In)fidelity	in)fidelity	NN
cord-256201-vjzfzshh	233	19	Revealed	reveal	VBN
cord-256201-vjzfzshh	233	20	by	by	IN
cord-256201-vjzfzshh	233	21	Kinetic	Kinetic	NNP
cord-256201-vjzfzshh	233	22	Analysis	Analysis	NNP
cord-256201-vjzfzshh	233	23	of	of	IN
cord-256201-vjzfzshh	233	24	the	the	DT
cord-256201-vjzfzshh	233	25	Polymerase	Polymerase	NNP
cord-256201-vjzfzshh	233	26	Encoded	encode	VBN
cord-256201-vjzfzshh	233	27	by	by	IN
cord-256201-vjzfzshh	233	28	a	a	DT
cord-256201-vjzfzshh	233	29	Foot	Foot	NNP
cord-256201-vjzfzshh	233	30	-	-	HYPH
cord-256201-vjzfzshh	233	31	and	and	CC
cord-256201-vjzfzshh	233	32	-	-	HYPH
cord-256201-vjzfzshh	233	33	Mouth	Mouth	NNP
cord-256201-vjzfzshh	233	34	Disease	Disease	NNP
cord-256201-vjzfzshh	233	35	Virus	Virus	NNP
cord-256201-vjzfzshh	233	36	Mutant	Mutant	NNP
cord-256201-vjzfzshh	233	37	with	with	IN
cord-256201-vjzfzshh	233	38	Reduced	reduce	VBN
cord-256201-vjzfzshh	233	39	Sensitivity	sensitivity	NN
cord-256201-vjzfzshh	233	40	to	to	IN
cord-256201-vjzfzshh	233	41	Ribavirin	Ribavirin	NNP
cord-256201-vjzfzshh	233	42	Characterization	characterization	NN
cord-256201-vjzfzshh	233	43	of	of	IN
cord-256201-vjzfzshh	233	44	DNA	dna	NN
cord-256201-vjzfzshh	233	45	Adenine	Adenine	NNP
cord-256201-vjzfzshh	233	46	Methylation	Methylation	NNP
cord-256201-vjzfzshh	233	47	Mutants	mutant	NNS
cord-256201-vjzfzshh	233	48	of	of	IN
cord-256201-vjzfzshh	233	49	Escherichia	Escherichia	NNP
cord-256201-vjzfzshh	233	50	coli	coli	VBZ
cord-256201-vjzfzshh	233	51	K12	K12	NNP
cord-256201-vjzfzshh	233	52	Correlation	Correlation	NNP
cord-256201-vjzfzshh	233	53	between	between	IN
cord-256201-vjzfzshh	233	54	Mutation	Mutation	NNP
cord-256201-vjzfzshh	233	55	Rate	Rate	NNP
cord-256201-vjzfzshh	233	56	and	and	CC
cord-256201-vjzfzshh	233	57	Genome	Genome	NNP
cord-256201-vjzfzshh	233	58	Size	size	NN
cord-256201-vjzfzshh	233	59	in	in	IN
cord-256201-vjzfzshh	233	60	Riboviruses	Riboviruses	NNP
cord-256201-vjzfzshh	233	61	:	:	:
cord-256201-vjzfzshh	233	62	Mutation	mutation	NN
cord-256201-vjzfzshh	233	63	Rate	rate	NN
cord-256201-vjzfzshh	233	64	of	of	IN
cord-256201-vjzfzshh	233	65	Bacteriophage	Bacteriophage	NNP
cord-256201-vjzfzshh	233	66	Qb	Qb	NNP
cord-256201-vjzfzshh	233	67	Natural	Natural	NNP
cord-256201-vjzfzshh	233	68	Selection	Selection	NNP
cord-256201-vjzfzshh	233	69	Fails	fail	VBZ
cord-256201-vjzfzshh	233	70	to	to	TO
cord-256201-vjzfzshh	233	71	Optimize	optimize	VB
cord-256201-vjzfzshh	233	72	Mutation	mutation	NN
cord-256201-vjzfzshh	233	73	Rates	Rates	NNPS
cord-256201-vjzfzshh	233	74	for	for	IN
cord-256201-vjzfzshh	233	75	Long	Long	NNP
cord-256201-vjzfzshh	233	76	-	-	HYPH
cord-256201-vjzfzshh	233	77	Term	term	NN
cord-256201-vjzfzshh	233	78	Adaptation	adaptation	NN
cord-256201-vjzfzshh	233	79	on	on	IN
cord-256201-vjzfzshh	233	80	Rugged	Rugged	NNP
cord-256201-vjzfzshh	233	81	Fitness	Fitness	NNP
cord-256201-vjzfzshh	233	82	Landscapes	Landscapes	NNP
cord-256201-vjzfzshh	233	83	Arbovirus	Arbovirus	NNP
cord-256201-vjzfzshh	233	84	High	High	NNP
cord-256201-vjzfzshh	233	85	Fidelity	Fidelity	NNP
cord-256201-vjzfzshh	233	86	Variant	variant	NN
cord-256201-vjzfzshh	234	1	Loses	lose	VBZ
cord-256201-vjzfzshh	234	2	Fitness	Fitness	NNP
cord-256201-vjzfzshh	234	3	in	in	IN
cord-256201-vjzfzshh	234	4	Mosquitoes	Mosquitoes	NNPS
cord-256201-vjzfzshh	234	5	and	and	CC
cord-256201-vjzfzshh	234	6	Mice	Mice	NNP
cord-256201-vjzfzshh	234	7	Mutation	Mutation	NNP
cord-256201-vjzfzshh	234	8	Rate	rate	NN
cord-256201-vjzfzshh	234	9	of	of	IN
cord-256201-vjzfzshh	234	10	Bacteriophage	Bacteriophage	NNP
cord-256201-vjzfzshh	234	11	/X174	/X174	.
cord-256201-vjzfzshh	235	1	Modified	modify	VBN
cord-256201-vjzfzshh	235	2	through	through	IN
cord-256201-vjzfzshh	235	3	Changes	change	NNS
cord-256201-vjzfzshh	235	4	in	in	IN
cord-256201-vjzfzshh	235	5	GATC	GATC	NNP
cord-256201-vjzfzshh	235	6	Sequence	Sequence	NNP
cord-256201-vjzfzshh	235	7	Context	Context	NNP
cord-256201-vjzfzshh	235	8	Coronaviruses	Coronaviruses	NNP
cord-256201-vjzfzshh	235	9	:	:	:
cord-256201-vjzfzshh	236	1	An	an	DT
cord-256201-vjzfzshh	236	2	RNA	RNA	NNP
cord-256201-vjzfzshh	236	3	Proofreading	Proofreading	NNP
cord-256201-vjzfzshh	236	4	Machine	machine	NN
cord-256201-vjzfzshh	236	5	Regulates	regulate	VBZ
cord-256201-vjzfzshh	236	6	Replication	Replication	NNP
cord-256201-vjzfzshh	236	7	Fidelity	Fidelity	NNP
cord-256201-vjzfzshh	236	8	and	and	CC
cord-256201-vjzfzshh	236	9	Diversity	Diversity	NNP
cord-256201-vjzfzshh	236	10	Counterselection	Counterselection	NNP
cord-256201-vjzfzshh	236	11	of	of	IN
cord-256201-vjzfzshh	236	12	GATC	GATC	NNP
cord-256201-vjzfzshh	236	13	Sequences	Sequences	NNPS
cord-256201-vjzfzshh	236	14	in	in	IN
cord-256201-vjzfzshh	236	15	Enterobacteriophages	Enterobacteriophages	NNPS
cord-256201-vjzfzshh	236	16	by	by	IN
cord-256201-vjzfzshh	236	17	the	the	DT
cord-256201-vjzfzshh	236	18	Components	Components	NNP
cord-256201-vjzfzshh	236	19	of	of	IN
cord-256201-vjzfzshh	236	20	the	the	DT
cord-256201-vjzfzshh	236	21	Methyl	Methyl	NNP
cord-256201-vjzfzshh	236	22	-	-	HYPH
cord-256201-vjzfzshh	236	23	Directed	direct	VBN
cord-256201-vjzfzshh	236	24	Mismatch	Mismatch	NNP
cord-256201-vjzfzshh	236	25	Repair	Repair	NNP
cord-256201-vjzfzshh	236	26	System	System	NNP
cord-256201-vjzfzshh	236	27	Nucleoside	Nucleoside	NNP
cord-256201-vjzfzshh	236	28	Analogue	Analogue	NNP
cord-256201-vjzfzshh	236	29	Mutagenesis	Mutagenesis	NNP
cord-256201-vjzfzshh	236	30	of	of	IN
cord-256201-vjzfzshh	236	31	a	a	DT
cord-256201-vjzfzshh	236	32	Single	Single	NNP
cord-256201-vjzfzshh	236	33	-	-	HYPH
cord-256201-vjzfzshh	236	34	Stranded	stranded	JJ
cord-256201-vjzfzshh	236	35	DNA	dna	NN
cord-256201-vjzfzshh	236	36	Virus	virus	NN
cord-256201-vjzfzshh	236	37	:	:	:
cord-256201-vjzfzshh	236	38	Evolution	evolution	NN
cord-256201-vjzfzshh	236	39	and	and	CC
cord-256201-vjzfzshh	236	40	Resistance	Resistance	NNP
cord-256201-vjzfzshh	236	41	A	a	DT
cord-256201-vjzfzshh	236	42	Constant	constant	JJ
cord-256201-vjzfzshh	236	43	Rate	rate	NN
cord-256201-vjzfzshh	236	44	of	of	IN
cord-256201-vjzfzshh	236	45	Spontaneous	Spontaneous	NNP
cord-256201-vjzfzshh	236	46	Mutation	Mutation	NNP
cord-256201-vjzfzshh	236	47	in	in	IN
cord-256201-vjzfzshh	236	48	DNA	DNA	NNP
cord-256201-vjzfzshh	236	49	-	-	HYPH
cord-256201-vjzfzshh	236	50	Based	base	VBN
cord-256201-vjzfzshh	236	51	Microbes	Microbes	NNPS
cord-256201-vjzfzshh	236	52	Suppression	Suppression	NNP
cord-256201-vjzfzshh	236	53	of	of	IN
cord-256201-vjzfzshh	236	54	Chemical	Chemical	NNP
cord-256201-vjzfzshh	236	55	Mutagenesis	Mutagenesis	NNP
cord-256201-vjzfzshh	236	56	in	in	IN
cord-256201-vjzfzshh	236	57	Bacteriophage	Bacteriophage	NNP
cord-256201-vjzfzshh	236	58	T4	T4	NNP
cord-256201-vjzfzshh	236	59	by	by	IN
cord-256201-vjzfzshh	236	60	Genetically	genetically	RB
cord-256201-vjzfzshh	236	61	Modified	modify	VBN
cord-256201-vjzfzshh	236	62	DNA	DNA	NNP
cord-256201-vjzfzshh	236	63	Polymerases	Polymerases	NNP
cord-256201-vjzfzshh	236	64	Rates	Rates	NNPS
cord-256201-vjzfzshh	236	65	of	of	IN
cord-256201-vjzfzshh	236	66	Evolutionary	Evolutionary	NNP
cord-256201-vjzfzshh	236	67	Change	change	NN
cord-256201-vjzfzshh	236	68	in	in	IN
cord-256201-vjzfzshh	236	69	Viruses	virus	NNS
cord-256201-vjzfzshh	236	70	:	:	:
cord-256201-vjzfzshh	236	71	Patterns	pattern	NNS
cord-256201-vjzfzshh	236	72	and	and	CC
cord-256201-vjzfzshh	236	73	Determinants	Determinants	NNPS
cord-256201-vjzfzshh	236	74	Host	Host	NNP
cord-256201-vjzfzshh	236	75	and	and	CC
cord-256201-vjzfzshh	236	76	/X174	/X174	NNP
cord-256201-vjzfzshh	236	77	Mutations	mutation	NNS
cord-256201-vjzfzshh	236	78	Affecting	affect	VBG
cord-256201-vjzfzshh	236	79	the	the	DT
cord-256201-vjzfzshh	236	80	Morphogenesis	Morphogenesis	NNP
cord-256201-vjzfzshh	236	81	or	or	CC
cord-256201-vjzfzshh	236	82	Stabilization	Stabilization	NNP
cord-256201-vjzfzshh	236	83	of	of	IN
cord-256201-vjzfzshh	236	84	the	the	DT
cord-256201-vjzfzshh	236	85	50S	50s	CD
cord-256201-vjzfzshh	236	86	Complex	Complex	NNP
cord-256201-vjzfzshh	236	87	,	,	,
cord-256201-vjzfzshh	236	88	a	a	DT
cord-256201-vjzfzshh	236	89	Single	Single	NNP
cord-256201-vjzfzshh	236	90	-	-	HYPH
cord-256201-vjzfzshh	236	91	Stranded	strand	VBN
cord-256201-vjzfzshh	236	92	DNA	dna	NN
cord-256201-vjzfzshh	237	1	Synthesizing	synthesize	VBG
cord-256201-vjzfzshh	237	2	Intermediate	Intermediate	NNP
cord-256201-vjzfzshh	237	3	DNA	dna	NN
cord-256201-vjzfzshh	237	4	Polymerase	Polymerase	NNP
cord-256201-vjzfzshh	237	5	Accuracy	Accuracy	NNP
cord-256201-vjzfzshh	237	6	and	and	CC
cord-256201-vjzfzshh	237	7	Spontaneous	Spontaneous	NNP
cord-256201-vjzfzshh	237	8	Mutation	Mutation	NNP
cord-256201-vjzfzshh	237	9	Rates	Rates	NNPS
cord-256201-vjzfzshh	237	10	:	:	:
cord-256201-vjzfzshh	237	11	Frequencies	frequency	NNS
cord-256201-vjzfzshh	237	12	of	of	IN
cord-256201-vjzfzshh	237	13	Purine	Purine	NNP
cord-256201-vjzfzshh	237	14	.	.	.
cord-256201-vjzfzshh	238	1	Purine	Purine	NNP
cord-256201-vjzfzshh	238	2	,	,	,
cord-256201-vjzfzshh	238	3	Purine	Purine	NNP
cord-256201-vjzfzshh	238	4	.	.	.
cord-256201-vjzfzshh	239	1	Pyrimidine	Pyrimidine	NNP
cord-256201-vjzfzshh	239	2	,	,	,
cord-256201-vjzfzshh	239	3	and	and	CC
cord-256201-vjzfzshh	239	4	Pyrimidine	Pyrimidine	NNP
cord-256201-vjzfzshh	239	5	.	.	.
cord-256201-vjzfzshh	240	1	Pyrimidine	Pyrimidine	NNP
cord-256201-vjzfzshh	240	2	Mismatches	mismatch	NNS
cord-256201-vjzfzshh	240	3	during	during	IN
cord-256201-vjzfzshh	240	4	DNA	DNA	NNP
cord-256201-vjzfzshh	240	5	Replication	replication	NN
cord-256201-vjzfzshh	240	6	DNA	dna	NN
cord-256201-vjzfzshh	240	7	Replication	Replication	NNP
cord-256201-vjzfzshh	240	8	Fidelity	Fidelity	NNP
cord-256201-vjzfzshh	240	9	in	in	IN
cord-256201-vjzfzshh	240	10	Escherichia	Escherichia	NNP
cord-256201-vjzfzshh	240	11	coli	coli	NNS
cord-256201-vjzfzshh	240	12	:	:	:
cord-256201-vjzfzshh	241	1	A	a	DT
cord-256201-vjzfzshh	241	2	Multi	multi	JJ
cord-256201-vjzfzshh	241	3	-	-	JJ
cord-256201-vjzfzshh	241	4	DNA	dna	NN
cord-256201-vjzfzshh	241	5	Polymerase	Polymerase	NNP
cord-256201-vjzfzshh	241	6	Affair	Affair	NNP
cord-256201-vjzfzshh	241	7	Role	role	NN
cord-256201-vjzfzshh	241	8	of	of	IN
cord-256201-vjzfzshh	241	9	RecA	RecA	NNP
cord-256201-vjzfzshh	241	10	and	and	CC
cord-256201-vjzfzshh	241	11	the	the	DT
cord-256201-vjzfzshh	241	12	SOS	SOS	NNP
cord-256201-vjzfzshh	241	13	Response	Response	NNP
cord-256201-vjzfzshh	241	14	in	in	IN
cord-256201-vjzfzshh	241	15	Thymineless	Thymineless	NNP
cord-256201-vjzfzshh	241	16	Death	Death	NNP
cord-256201-vjzfzshh	241	17	in	in	IN
cord-256201-vjzfzshh	241	18	Escherichia	Escherichia	NNP
cord-256201-vjzfzshh	241	19	coli	coli	NNS
cord-256201-vjzfzshh	241	20	DNA	dna	NN
cord-256201-vjzfzshh	241	21	Mismatch	mismatch	NN
cord-256201-vjzfzshh	241	22	Repair	repair	NN
cord-256201-vjzfzshh	241	23	in	in	IN
cord-256201-vjzfzshh	241	24	Eukaryotes	eukaryote	NNS
cord-256201-vjzfzshh	241	25	and	and	CC
cord-256201-vjzfzshh	241	26	Bacteria	Bacteria	NNPS
cord-256201-vjzfzshh	241	27	Mutation	Mutation	NNP
cord-256201-vjzfzshh	241	28	as	as	IN
cord-256201-vjzfzshh	241	29	a	a	DT
cord-256201-vjzfzshh	241	30	Stress	Stress	NNP
cord-256201-vjzfzshh	241	31	Response	response	NN
cord-256201-vjzfzshh	241	32	and	and	CC
cord-256201-vjzfzshh	241	33	the	the	DT
cord-256201-vjzfzshh	241	34	Regulation	Regulation	NNP
cord-256201-vjzfzshh	241	35	of	of	IN
cord-256201-vjzfzshh	241	36	Evolvability	Evolvability	NNP
cord-256201-vjzfzshh	241	37	Mutational	Mutational	NNP
cord-256201-vjzfzshh	241	38	Robustness	Robustness	NNP
cord-256201-vjzfzshh	241	39	of	of	IN
cord-256201-vjzfzshh	241	40	an	an	DT
cord-256201-vjzfzshh	241	41	RNA	RNA	NNP
cord-256201-vjzfzshh	241	42	Virus	virus	NN
cord-256201-vjzfzshh	241	43	Influences	influence	VBZ
cord-256201-vjzfzshh	241	44	Sensitivity	Sensitivity	NNP
cord-256201-vjzfzshh	241	45	to	to	IN
cord-256201-vjzfzshh	241	46	Lethal	Lethal	NNP
cord-256201-vjzfzshh	241	47	Mutagenesis	Mutagenesis	NNP
cord-256201-vjzfzshh	241	48	Characterization	characterization	NN
cord-256201-vjzfzshh	241	49	of	of	IN
cord-256201-vjzfzshh	241	50	the	the	DT
cord-256201-vjzfzshh	241	51	Host	Host	NNP
cord-256201-vjzfzshh	241	52	Factors	Factors	NNP
cord-256201-vjzfzshh	241	53	Required	require	VBN
cord-256201-vjzfzshh	241	54	for	for	IN
cord-256201-vjzfzshh	241	55	Hepadnavirus	Hepadnavirus	NNP
cord-256201-vjzfzshh	241	56	Covalently	Covalently	NNP
cord-256201-vjzfzshh	241	57	Closed	Closed	NNP
cord-256201-vjzfzshh	241	58	Circular	Circular	NNP
cord-256201-vjzfzshh	241	59	(	(	-LRB-
cord-256201-vjzfzshh	241	60	ccc	ccc	NNP
cord-256201-vjzfzshh	241	61	)	)	-RRB-
cord-256201-vjzfzshh	241	62	DNA	DNA	NNP
cord-256201-vjzfzshh	241	63	Formation	Formation	NNP
cord-256201-vjzfzshh	241	64	Impacts	impact	NNS
cord-256201-vjzfzshh	241	65	of	of	IN
cord-256201-vjzfzshh	241	66	Mutation	mutation	NN
cord-256201-vjzfzshh	241	67	Effects	Effects	NNPS
cord-256201-vjzfzshh	241	68	and	and	CC
cord-256201-vjzfzshh	241	69	Population	Population	NNP
cord-256201-vjzfzshh	241	70	Size	Size	NNP
cord-256201-vjzfzshh	241	71	on	on	IN
cord-256201-vjzfzshh	241	72	Mutation	mutation	NN
cord-256201-vjzfzshh	241	73	Rate	rate	NN
cord-256201-vjzfzshh	241	74	in	in	IN
cord-256201-vjzfzshh	241	75	Asexual	asexual	JJ
cord-256201-vjzfzshh	241	76	Populations	Populations	NNPS
cord-256201-vjzfzshh	241	77	:	:	:
cord-256201-vjzfzshh	242	1	A	a	DT
cord-256201-vjzfzshh	242	2	Simulation	Simulation	NNP
cord-256201-vjzfzshh	242	3	Study	Study	NNP
cord-256201-vjzfzshh	242	4	Postreplicative	Postreplicative	NNP
cord-256201-vjzfzshh	242	5	Mismatch	mismatch	NN
cord-256201-vjzfzshh	242	6	Repair	repair	NN
cord-256201-vjzfzshh	243	1	The	the	DT
cord-256201-vjzfzshh	243	2	Effect	effect	NN
cord-256201-vjzfzshh	243	3	of	of	IN
cord-256201-vjzfzshh	243	4	Deleterious	deleterious	JJ
cord-256201-vjzfzshh	243	5	Alleles	Alleles	NNPS
cord-256201-vjzfzshh	243	6	on	on	IN
cord-256201-vjzfzshh	243	7	Adaptation	Adaptation	NNP
cord-256201-vjzfzshh	243	8	in	in	IN
cord-256201-vjzfzshh	243	9	Asexual	Asexual	NNP
cord-256201-vjzfzshh	243	10	Populations	Populations	NNPS
cord-256201-vjzfzshh	244	1	Bacterial	bacterial	JJ
cord-256201-vjzfzshh	244	2	Hypermutation	Hypermutation	NNP
cord-256201-vjzfzshh	244	3	:	:	:
cord-256201-vjzfzshh	245	1	Clinical	clinical	JJ
cord-256201-vjzfzshh	245	2	implications	implication	NNS
cord-256201-vjzfzshh	245	3	Repair	Repair	NNP
cord-256201-vjzfzshh	245	4	of	of	IN
cord-256201-vjzfzshh	245	5	a	a	DT
cord-256201-vjzfzshh	245	6	Mismatch	mismatch	NN
cord-256201-vjzfzshh	245	7	is	be	VBZ
cord-256201-vjzfzshh	245	8	Influenced	influence	VBN
cord-256201-vjzfzshh	245	9	by	by	IN
cord-256201-vjzfzshh	245	10	the	the	DT
cord-256201-vjzfzshh	245	11	Base	Base	NNP
cord-256201-vjzfzshh	245	12	Composition	Composition	NNP
cord-256201-vjzfzshh	245	13	of	of	IN
cord-256201-vjzfzshh	245	14	the	the	DT
cord-256201-vjzfzshh	245	15	Surrounding	surround	VBG
cord-256201-vjzfzshh	245	16	Nucleotide	Nucleotide	NNP
cord-256201-vjzfzshh	245	17	Sequence	sequence	NN
cord-256201-vjzfzshh	246	1	Error	error	NN
cord-256201-vjzfzshh	246	2	-	-	HYPH
cord-256201-vjzfzshh	246	3	Prone	prone	JJ
cord-256201-vjzfzshh	246	4	DNA	dna	NN
cord-256201-vjzfzshh	246	5	Polymerase	polymerase	NN
cord-256201-vjzfzshh	246	6	IV	IV	NNP
cord-256201-vjzfzshh	246	7	is	be	VBZ
cord-256201-vjzfzshh	246	8	Regulated	regulate	VBN
cord-256201-vjzfzshh	246	9	by	by	IN
cord-256201-vjzfzshh	246	10	the	the	DT
cord-256201-vjzfzshh	246	11	Heat	Heat	NNP
cord-256201-vjzfzshh	246	12	Shock	Shock	NNP
cord-256201-vjzfzshh	246	13	Chaperone	Chaperone	NNP
cord-256201-vjzfzshh	246	14	GroE	GroE	NNP
cord-256201-vjzfzshh	246	15	in	in	IN
cord-256201-vjzfzshh	246	16	Escherichia	Escherichia	NNP
cord-256201-vjzfzshh	246	17	coli	coli	VBZ
cord-256201-vjzfzshh	246	18	High	High	NNP
cord-256201-vjzfzshh	246	19	Mutation	Mutation	NNP
cord-256201-vjzfzshh	246	20	Frequencies	Frequencies	NNPS
cord-256201-vjzfzshh	246	21	among	among	IN
cord-256201-vjzfzshh	246	22	Escherichia	Escherichia	NNP
cord-256201-vjzfzshh	246	23	coli	coli	NNS
cord-256201-vjzfzshh	246	24	and	and	CC
cord-256201-vjzfzshh	246	25	Salmonella	Salmonella	NNP
cord-256201-vjzfzshh	246	26	Pathogens	Pathogens	NNPS
cord-256201-vjzfzshh	246	27	Rate	Rate	NNP
cord-256201-vjzfzshh	246	28	and	and	CC
cord-256201-vjzfzshh	246	29	Molecular	Molecular	NNP
cord-256201-vjzfzshh	246	30	Spectrum	Spectrum	NNP
cord-256201-vjzfzshh	246	31	of	of	IN
cord-256201-vjzfzshh	246	32	Spontaneous	Spontaneous	NNP
cord-256201-vjzfzshh	246	33	Mutations	Mutations	NNPS
cord-256201-vjzfzshh	246	34	in	in	IN
cord-256201-vjzfzshh	246	35	the	the	DT
cord-256201-vjzfzshh	246	36	Bacterium	bacterium	NN
cord-256201-vjzfzshh	246	37	Escherichia	Escherichia	NNP
cord-256201-vjzfzshh	246	38	coli	coli	NNS
cord-256201-vjzfzshh	246	39	as	as	IN
cord-256201-vjzfzshh	246	40	Determined	determine	VBN
cord-256201-vjzfzshh	246	41	by	by	IN
cord-256201-vjzfzshh	246	42	Whole	Whole	NNP
cord-256201-vjzfzshh	246	43	-	-	HYPH
cord-256201-vjzfzshh	246	44	Genome	Genome	NNP
cord-256201-vjzfzshh	246	45	Sequencing	Sequencing	NNP
cord-256201-vjzfzshh	246	46	Mechanisms	Mechanisms	NNPS
cord-256201-vjzfzshh	246	47	and	and	CC
cord-256201-vjzfzshh	246	48	Functions	Functions	NNPS
cord-256201-vjzfzshh	246	49	of	of	IN
cord-256201-vjzfzshh	246	50	DNA	dna	NN
cord-256201-vjzfzshh	246	51	Mismatch	mismatch	NN
cord-256201-vjzfzshh	246	52	Repair	repair	NN
cord-256201-vjzfzshh	246	53	Viruses	virus	NNS
cord-256201-vjzfzshh	246	54	and	and	CC
cord-256201-vjzfzshh	246	55	the	the	DT
cord-256201-vjzfzshh	246	56	DNA	DNA	NNP
cord-256201-vjzfzshh	246	57	Damage	damage	NN
cord-256201-vjzfzshh	246	58	Response	response	NN
cord-256201-vjzfzshh	246	59	:	:	:
cord-256201-vjzfzshh	247	1	Activation	activation	NN
cord-256201-vjzfzshh	247	2	and	and	CC
cord-256201-vjzfzshh	247	3	Antagonism	antagonism	NN
cord-256201-vjzfzshh	248	1	The	the	DT
cord-256201-vjzfzshh	248	2	Lower	low	JJR
cord-256201-vjzfzshh	248	3	Bound	Bound	NNP
cord-256201-vjzfzshh	248	4	to	to	IN
cord-256201-vjzfzshh	248	5	the	the	DT
cord-256201-vjzfzshh	248	6	Evolution	evolution	NN
cord-256201-vjzfzshh	248	7	of	of	IN
cord-256201-vjzfzshh	249	1	Mutation	mutation	NN
cord-256201-vjzfzshh	249	2	Rates	rate	NNS
cord-256201-vjzfzshh	249	3	Mutations	mutation	NNS
cord-256201-vjzfzshh	249	4	Arising	arise	VBG
cord-256201-vjzfzshh	249	5	during	during	IN
cord-256201-vjzfzshh	249	6	Repair	Repair	NNP
cord-256201-vjzfzshh	249	7	of	of	IN
cord-256201-vjzfzshh	249	8	Chromosome	Chromosome	NNP
cord-256201-vjzfzshh	249	9	Breaks	Breaks	NNP
cord-256201-vjzfzshh	249	10	Virus	Virus	NNP
cord-256201-vjzfzshh	249	11	Mutators	Mutators	NNP
cord-256201-vjzfzshh	249	12	and	and	CC
cord-256201-vjzfzshh	249	13	antimUtators	antimutator	NNS
cord-256201-vjzfzshh	249	14	:	:	:
cord-256201-vjzfzshh	250	1	Roles	role	NNS
cord-256201-vjzfzshh	250	2	in	in	IN
cord-256201-vjzfzshh	250	3	Evolution	Evolution	NNP
cord-256201-vjzfzshh	250	4	,	,	,
cord-256201-vjzfzshh	250	5	Pathogenesis	Pathogenesis	NNP
cord-256201-vjzfzshh	250	6	and	and	CC
cord-256201-vjzfzshh	250	7	Emergence	Emergence	NNP
cord-256201-vjzfzshh	250	8	DNA	DNA	NNP
cord-256201-vjzfzshh	250	9	Methylation	Methylation	NNP
cord-256201-vjzfzshh	250	10	and	and	CC
cord-256201-vjzfzshh	250	11	Mutator	Mutator	NNP
cord-256201-vjzfzshh	250	12	Genes	Genes	NNPS
cord-256201-vjzfzshh	250	13	in	in	IN
cord-256201-vjzfzshh	250	14	Escherichia	Escherichia	NNP
cord-256201-vjzfzshh	250	15	coli	coli	VBZ
cord-256201-vjzfzshh	250	16	K-12	K-12	NNP
cord-256201-vjzfzshh	250	17	DNA	dna	NN
cord-256201-vjzfzshh	250	18	Mismatch	mismatch	NN
cord-256201-vjzfzshh	250	19	Repair	Repair	NNP
cord-256201-vjzfzshh	250	20	and	and	CC
cord-256201-vjzfzshh	250	21	Mutation	Mutation	NNP
cord-256201-vjzfzshh	250	22	Avoidance	Avoidance	NNP
cord-256201-vjzfzshh	250	23	Pathways	Pathways	NNPS
cord-256201-vjzfzshh	250	24	Selection	Selection	NNP
cord-256201-vjzfzshh	250	25	against	against	IN
cord-256201-vjzfzshh	250	26	Dam	Dam	NNP
cord-256201-vjzfzshh	250	27	Methylation	Methylation	NNP
cord-256201-vjzfzshh	250	28	Sites	site	NNS
cord-256201-vjzfzshh	250	29	in	in	IN
cord-256201-vjzfzshh	250	30	the	the	DT
cord-256201-vjzfzshh	250	31	Genomes	Genomes	NNPS
cord-256201-vjzfzshh	250	32	of	of	IN
cord-256201-vjzfzshh	250	33	DNA	DNA	NNP
cord-256201-vjzfzshh	250	34	of	of	IN
cord-256201-vjzfzshh	250	35	Enterobacteriophages	Enterobacteriophages	NNP
cord-256201-vjzfzshh	250	36	Mutation	Mutation	NNP
cord-256201-vjzfzshh	250	37	Rates	Rates	NNPS
cord-256201-vjzfzshh	250	38	and	and	CC
cord-256201-vjzfzshh	250	39	Intrinsic	Intrinsic	NNP
cord-256201-vjzfzshh	250	40	Fidelity	Fidelity	NNP
cord-256201-vjzfzshh	250	41	of	of	IN
cord-256201-vjzfzshh	250	42	Retroviral	Retroviral	NNP
cord-256201-vjzfzshh	250	43	Reverse	Reverse	NNP
cord-256201-vjzfzshh	250	44	Transcriptases	Transcriptases	NNPS
cord-256201-vjzfzshh	250	45	Mismatch	mismatch	NN
cord-256201-vjzfzshh	250	46	Repair	repair	NN
cord-256201-vjzfzshh	250	47	in	in	IN
cord-256201-vjzfzshh	250	48	Replication	Replication	NNP
cord-256201-vjzfzshh	250	49	Fidelity	Fidelity	NNP
cord-256201-vjzfzshh	250	50	,	,	,
cord-256201-vjzfzshh	250	51	Genetic	Genetic	NNP
cord-256201-vjzfzshh	250	52	Recombination	Recombination	NNP
cord-256201-vjzfzshh	250	53	,	,	,
cord-256201-vjzfzshh	250	54	and	and	CC
cord-256201-vjzfzshh	250	55	Cancer	Cancer	NNP
cord-256201-vjzfzshh	250	56	Biology	Biology	NNP
cord-256201-vjzfzshh	251	1	The	the	DT
cord-256201-vjzfzshh	251	2	Rate	rate	NN
cord-256201-vjzfzshh	251	3	of	of	IN
cord-256201-vjzfzshh	251	4	Adaptation	adaptation	NN
cord-256201-vjzfzshh	251	5	in	in	IN
cord-256201-vjzfzshh	251	6	Asexuals	Asexuals	NNPS
cord-256201-vjzfzshh	251	7	Delayed	delay	VBN
cord-256201-vjzfzshh	251	8	Lysis	lysis	NN
cord-256201-vjzfzshh	251	9	Confers	confer	VBZ
cord-256201-vjzfzshh	251	10	Resistance	resistance	NN
cord-256201-vjzfzshh	251	11	to	to	IN
cord-256201-vjzfzshh	251	12	the	the	DT
cord-256201-vjzfzshh	251	13	Nucleoside	Nucleoside	NNP
cord-256201-vjzfzshh	251	14	Analogue	Analogue	NNP
cord-256201-vjzfzshh	251	15	5-Fluorouracil	5-Fluorouracil	NNP
cord-256201-vjzfzshh	251	16	and	and	CC
cord-256201-vjzfzshh	251	17	Alleviates	alleviate	VBZ
cord-256201-vjzfzshh	251	18	Mutation	Mutation	NNP
cord-256201-vjzfzshh	251	19	Accumulation	Accumulation	NNP
cord-256201-vjzfzshh	251	20	in	in	IN
cord-256201-vjzfzshh	251	21	the	the	DT
cord-256201-vjzfzshh	251	22	Single	Single	NNP
cord-256201-vjzfzshh	251	23	-	-	HYPH
cord-256201-vjzfzshh	251	24	Stranded	stranded	JJ
cord-256201-vjzfzshh	251	25	DNA	dna	NN
cord-256201-vjzfzshh	251	26	Bacteriophage	Bacteriophage	NNP
cord-256201-vjzfzshh	251	27	/X174	/X174	,
cord-256201-vjzfzshh	251	28	'	'	''
cord-256201-vjzfzshh	251	29	A	a	DT
cord-256201-vjzfzshh	251	30	Single	Single	NNP
cord-256201-vjzfzshh	251	31	Mutation	Mutation	NNP
cord-256201-vjzfzshh	251	32	in	in	IN
cord-256201-vjzfzshh	251	33	Poliovirus	Poliovirus	NNP
cord-256201-vjzfzshh	251	34	RNA	RNA	NNP
cord-256201-vjzfzshh	251	35	-	-	HYPH
cord-256201-vjzfzshh	251	36	Dependent	Dependent	NNP
cord-256201-vjzfzshh	251	37	RNA	RNA	NNP
cord-256201-vjzfzshh	251	38	Polymerase	Polymerase	NNP
cord-256201-vjzfzshh	251	39	Confers	confer	VBZ
cord-256201-vjzfzshh	251	40	Resistance	resistance	NN
cord-256201-vjzfzshh	251	41	to	to	IN
cord-256201-vjzfzshh	251	42	Mutagenic	Mutagenic	NNP
cord-256201-vjzfzshh	251	43	Nucleotide	Nucleotide	NNP
cord-256201-vjzfzshh	251	44	Analogs	Analogs	NNP
cord-256201-vjzfzshh	251	45	via	via	IN
cord-256201-vjzfzshh	251	46	Increased	increase	VBN
cord-256201-vjzfzshh	251	47	Fidelity	Fidelity	NNP
cord-256201-vjzfzshh	251	48	Effects	effect	NNS
cord-256201-vjzfzshh	251	49	of	of	IN
cord-256201-vjzfzshh	251	50	High	high	JJ
cord-256201-vjzfzshh	251	51	Levels	level	NNS
cord-256201-vjzfzshh	251	52	of	of	IN
cord-256201-vjzfzshh	251	53	DNA	dna	NN
cord-256201-vjzfzshh	251	54	Adenine	Adenine	NNP
cord-256201-vjzfzshh	251	55	Methylation	Methylation	NNP
cord-256201-vjzfzshh	251	56	on	on	IN
cord-256201-vjzfzshh	251	57	Methyl	Methyl	NNP
cord-256201-vjzfzshh	251	58	-	-	HYPH
cord-256201-vjzfzshh	251	59	Directed	direct	VBN
cord-256201-vjzfzshh	251	60	Mismatch	Mismatch	NNP
cord-256201-vjzfzshh	251	61	Repair	Repair	NNP
cord-256201-vjzfzshh	251	62	in	in	IN
cord-256201-vjzfzshh	251	63	Escherichia	Escherichia	NNP
cord-256201-vjzfzshh	251	64	coli	coli	VBZ
cord-256201-vjzfzshh	251	65	Isolation	isolation	NN
cord-256201-vjzfzshh	251	66	and	and	CC
cord-256201-vjzfzshh	251	67	Characterization	characterization	NN
cord-256201-vjzfzshh	251	68	of	of	IN
cord-256201-vjzfzshh	251	69	Escherichia	Escherichia	NNP
cord-256201-vjzfzshh	251	70	coli	coli	VBZ
cord-256201-vjzfzshh	251	71	Antimutators	Antimutators	NNP
cord-256201-vjzfzshh	251	72	'	'	POS
cord-256201-vjzfzshh	251	73	,	,	.
cord-256201-vjzfzshh	252	1	A	a	DT
cord-256201-vjzfzshh	252	2	New	New	NNP
cord-256201-vjzfzshh	252	3	Strategy	Strategy	NNP
cord-256201-vjzfzshh	252	4	to	to	TO
cord-256201-vjzfzshh	252	5	Study	study	VB
cord-256201-vjzfzshh	252	6	the	the	DT
cord-256201-vjzfzshh	252	7	Nature	Nature	NNP
cord-256201-vjzfzshh	252	8	and	and	CC
cord-256201-vjzfzshh	252	9	Origin	Origin	NNP
cord-256201-vjzfzshh	252	10	of	of	IN
cord-256201-vjzfzshh	252	11	Spontaneous	Spontaneous	NNP
cord-256201-vjzfzshh	252	12	Mutations	Mutations	NNPS
cord-256201-vjzfzshh	252	13	Spontaneous	Spontaneous	NNP
cord-256201-vjzfzshh	252	14	Mutant	Mutant	NNP
cord-256201-vjzfzshh	252	15	Frequency	Frequency	NNP
cord-256201-vjzfzshh	252	16	and	and	CC
cord-256201-vjzfzshh	252	17	Mutation	Mutation	NNP
cord-256201-vjzfzshh	252	18	Spectrum	Spectrum	NNP
cord-256201-vjzfzshh	252	19	for	for	IN
cord-256201-vjzfzshh	252	20	The	the	DT
cord-256201-vjzfzshh	252	21	Accuracy	Accuracy	NNP
cord-256201-vjzfzshh	252	22	of	of	IN
cord-256201-vjzfzshh	252	23	Reverse	Reverse	NNP
cord-256201-vjzfzshh	252	24	Transcriptase	Transcriptase	NNP
cord-256201-vjzfzshh	252	25	from	from	IN
cord-256201-vjzfzshh	252	26	HIV-1	HIV-1	NNP
cord-256201-vjzfzshh	252	27	Evolving	evolve	VBG
cord-256201-vjzfzshh	252	28	Responsively	responsively	RB
cord-256201-vjzfzshh	252	29	:	:	:
cord-256201-vjzfzshh	252	30	Adaptive	Adaptive	NNP
cord-256201-vjzfzshh	252	31	Mutation	Mutation	NNP
cord-256201-vjzfzshh	252	32	'	'	POS
cord-256201-vjzfzshh	252	33	Viral	Viral	NNP
cord-256201-vjzfzshh	252	34	Mutation	Mutation	NNP
cord-256201-vjzfzshh	252	35	Rates	Rates	NNPS
cord-256201-vjzfzshh	252	36	Antimutator	Antimutator	NNP
cord-256201-vjzfzshh	252	37	Mutants	Mutants	NNPS
cord-256201-vjzfzshh	252	38	in	in	IN
cord-256201-vjzfzshh	252	39	Bacteriophage	Bacteriophage	NNP
cord-256201-vjzfzshh	252	40	T4	T4	NNP
cord-256201-vjzfzshh	252	41	and	and	CC
cord-256201-vjzfzshh	252	42	Escherichia	Escherichia	NNP
cord-256201-vjzfzshh	252	43	coli	coli	VBZ
cord-256201-vjzfzshh	252	44	DNA	dna	NN
cord-256201-vjzfzshh	252	45	Mismatch	mismatch	NN
cord-256201-vjzfzshh	252	46	Repair	repair	NN
cord-256201-vjzfzshh	252	47	:	:	:
cord-256201-vjzfzshh	253	1	Molecular	Molecular	NNP
cord-256201-vjzfzshh	253	2	Mechanisms	Mechanisms	NNPS
cord-256201-vjzfzshh	253	3	and	and	CC
cord-256201-vjzfzshh	253	4	Biological	Biological	NNP
cord-256201-vjzfzshh	253	5	Function	Function	NNP
cord-256201-vjzfzshh	254	1	Coronaviruses	Coronaviruses	NNP
cord-256201-vjzfzshh	255	1	Lacking	lack	VBG
cord-256201-vjzfzshh	255	2	Exoribonuclease	Exoribonuclease	NNP
cord-256201-vjzfzshh	255	3	Activity	Activity	NNP
cord-256201-vjzfzshh	255	4	are	be	VBP
cord-256201-vjzfzshh	255	5	Susceptible	susceptible	JJ
cord-256201-vjzfzshh	255	6	to	to	IN
cord-256201-vjzfzshh	255	7	lethal	lethal	JJ
cord-256201-vjzfzshh	255	8	Mutagenesis	Mutagenesis	NNP
cord-256201-vjzfzshh	255	9	:	:	:
cord-256201-vjzfzshh	256	1	Evidence	evidence	NN
cord-256201-vjzfzshh	256	2	for	for	IN
cord-256201-vjzfzshh	256	3	Proofreading	Proofreading	NNP
cord-256201-vjzfzshh	256	4	and	and	CC
cord-256201-vjzfzshh	256	5	Potential	Potential	NNP
cord-256201-vjzfzshh	256	6	Therapeutics	Therapeutics	NNPS
cord-256201-vjzfzshh	256	7	Evolution	Evolution	NNP
cord-256201-vjzfzshh	256	8	of	of	IN
cord-256201-vjzfzshh	256	9	High	High	NNP
cord-256201-vjzfzshh	256	10	Mutation	Mutation	NNP
cord-256201-vjzfzshh	256	11	Rates	Rates	NNPS
cord-256201-vjzfzshh	256	12	in	in	IN
cord-256201-vjzfzshh	256	13	Experimental	Experimental	NNP
cord-256201-vjzfzshh	256	14	Populations	Populations	NNPS
cord-256201-vjzfzshh	256	15	of	of	IN
cord-256201-vjzfzshh	256	16	E.	E.	NNP
cord-256201-vjzfzshh	256	17	coli	coli	NNS
cord-256201-vjzfzshh	256	18	Lack	lack	NN
cord-256201-vjzfzshh	256	19	of	of	IN
cord-256201-vjzfzshh	256	20	Evidence	evidence	NN
cord-256201-vjzfzshh	256	21	for	for	IN
cord-256201-vjzfzshh	256	22	Proofreading	proofreading	NN
cord-256201-vjzfzshh	256	23	Mechanisms	Mechanisms	NNPS
cord-256201-vjzfzshh	257	1	Associated	associate	VBN
cord-256201-vjzfzshh	257	2	with	with	IN
cord-256201-vjzfzshh	257	3	an	an	DT
cord-256201-vjzfzshh	257	4	RNA	RNA	NNP
cord-256201-vjzfzshh	257	5	Virus	virus	NN
cord-256201-vjzfzshh	257	6	Polymerase	Polymerase	NNP
cord-256201-vjzfzshh	257	7	Drift	Drift	NNP
cord-256201-vjzfzshh	257	8	-	-	HYPH
cord-256201-vjzfzshh	257	9	Barrier	Barrier	NNP
cord-256201-vjzfzshh	257	10	Hypothesis	Hypothesis	NNP
cord-256201-vjzfzshh	257	11	and	and	CC
cord-256201-vjzfzshh	257	12	Mutation	Mutation	NNP
cord-256201-vjzfzshh	257	13	-	-	HYPH
cord-256201-vjzfzshh	257	14	Rate	Rate	NNP
cord-256201-vjzfzshh	257	15	Evolution	Evolution	NNP
cord-256201-vjzfzshh	257	16	Conversion	conversion	NN
cord-256201-vjzfzshh	257	17	of	of	IN
cord-256201-vjzfzshh	257	18	/X174	/X174	NFP
cord-256201-vjzfzshh	257	19	Viral	Viral	NNP
cord-256201-vjzfzshh	257	20	DNA	DNA	NNP
cord-256201-vjzfzshh	257	21	to	to	IN
cord-256201-vjzfzshh	257	22	Double	double	JJ
cord-256201-vjzfzshh	257	23	-	-	HYPH
cord-256201-vjzfzshh	257	24	Stranded	strand	VBN
cord-256201-vjzfzshh	257	25	Form	form	NN
cord-256201-vjzfzshh	257	26	by	by	IN
cord-256201-vjzfzshh	257	27	Purified	Purified	NNP
cord-256201-vjzfzshh	257	28	Escherichia	Escherichia	NNP
cord-256201-vjzfzshh	257	29	coli	coli	NNS
cord-256201-vjzfzshh	257	30	Proteins	protein	NNS
cord-256201-vjzfzshh	258	1	We	-PRON-	PRP
cord-256201-vjzfzshh	258	2	thank	thank	VBP
cord-256201-vjzfzshh	258	3	Silvia	Silvia	NNP
cord-256201-vjzfzshh	258	4	Torres	Torres	NNP
cord-256201-vjzfzshh	258	5	and	and	CC
cord-256201-vjzfzshh	258	6	Pablo	Pablo	NNP
cord-256201-vjzfzshh	258	7	Herná	Herná	NNP
cord-256201-vjzfzshh	258	8	ndez	ndez	NN
cord-256201-vjzfzshh	258	9	for	for	IN
cord-256201-vjzfzshh	258	10	technical	technical	JJ
cord-256201-vjzfzshh	258	11	assistance	assistance	NN
cord-256201-vjzfzshh	258	12	.	.	.
cord-256201-vjzfzshh	259	1	This	this	DT
cord-256201-vjzfzshh	259	2	work	work	NN
cord-256201-vjzfzshh	259	3	was	be	VBD
cord-256201-vjzfzshh	259	4	supported	support	VBN
cord-256201-vjzfzshh	259	5	by	by	IN
cord-256201-vjzfzshh	259	6	grants	grant	NNS
cord-256201-vjzfzshh	259	7	from	from	IN
cord-256201-vjzfzshh	259	8	the	the	DT
cord-256201-vjzfzshh	259	9	Spanish	spanish	JJ
cord-256201-vjzfzshh	259	10	MINECO	MINECO	NNS
cord-256201-vjzfzshh	260	1	(	(	-LRB-
cord-256201-vjzfzshh	260	2	BFU2013	BFU2013	NNP
cord-256201-vjzfzshh	260	3	-	-	HYPH
cord-256201-vjzfzshh	260	4	41329	41329	CD
cord-256201-vjzfzshh	260	5	)	)	-RRB-
cord-256201-vjzfzshh	260	6	and	and	CC
cord-256201-vjzfzshh	260	7	the	the	DT
cord-256201-vjzfzshh	260	8	European	European	NNP
cord-256201-vjzfzshh	260	9	Research	Research	NNP
cord-256201-vjzfzshh	260	10	Council	Council	NNP
cord-256201-vjzfzshh	260	11	(	(	-LRB-
cord-256201-vjzfzshh	260	12	ERC-2011-StG-281191-VIRMUT	ERC-2011-StG-281191-VIRMUT	NNP
cord-256201-vjzfzshh	260	13	)	)	-RRB-
cord-256201-vjzfzshh	260	14	to	to	IN
cord-256201-vjzfzshh	260	15	R.S.	R.S.	NNP
cord-256201-vjzfzshh	260	16	,	,	,
cord-256201-vjzfzshh	260	17	and	and	CC
cord-256201-vjzfzshh	260	18	by	by	IN
cord-256201-vjzfzshh	260	19	a	a	DT
cord-256201-vjzfzshh	260	20	Ph.D.	ph.d.	NN
cord-256201-vjzfzshh	260	21	fellowship	fellowship	NN
cord-256201-vjzfzshh	260	22	from	from	IN
cord-256201-vjzfzshh	260	23	the	the	DT
cord-256201-vjzfzshh	260	24	Spanish	spanish	JJ
cord-256201-vjzfzshh	260	25	Ministerio	Ministerio	NNP
cord-256201-vjzfzshh	260	26	de	de	NNP
cord-256201-vjzfzshh	260	27	Educació	Educació	NNP
cord-256201-vjzfzshh	260	28	n	n	NNP
cord-256201-vjzfzshh	260	29	to	to	IN
cord-256201-vjzfzshh	260	30	M.P.-G.	M.P.-G.	NNP
cord-256201-vjzfzshh	261	1	Data	datum	NNS
cord-256201-vjzfzshh	261	2	are	be	VBP
cord-256201-vjzfzshh	261	3	available	available	JJ
cord-256201-vjzfzshh	261	4	on	on	IN
cord-256201-vjzfzshh	261	5	request	request	NN
cord-256201-vjzfzshh	261	6	.	.	.
cord-256201-vjzfzshh	262	1	Conflict	conflict	NN
cord-256201-vjzfzshh	262	2	of	of	IN
cord-256201-vjzfzshh	262	3	interest	interest	NN
cord-256201-vjzfzshh	262	4	:	:	:
cord-256201-vjzfzshh	262	5	None	none	NN
cord-256201-vjzfzshh	262	6	declared	declare	VBD
cord-256201-vjzfzshh	262	7	.	.	.