id	sid	tid	token	lemma	pos
cord-253295-82ydczid	1	1	key	key	JJ
cord-253295-82ydczid	1	2	:	:	:
cord-253295-82ydczid	1	3	cord-253295	cord-253295	NN
cord-253295-82ydczid	1	4	-	-	HYPH
cord-253295-82ydczid	1	5	82ydczid	82ydczid	CD
cord-253295-82ydczid	1	6	authors	author	NNS
cord-253295-82ydczid	1	7	:	:	:
cord-253295-82ydczid	1	8	Funkhouser	Funkhouser	NNP
cord-253295-82ydczid	1	9	,	,	,
cord-253295-82ydczid	1	10	William	William	NNP
cord-253295-82ydczid	1	11	K.	K.	NNP
cord-253295-82ydczid	1	12	title	title	NN
cord-253295-82ydczid	1	13	:	:	:
cord-253295-82ydczid	1	14	Pathology	pathology	NN
cord-253295-82ydczid	1	15	:	:	:
cord-253295-82ydczid	1	16	the	the	DT
cord-253295-82ydczid	1	17	clinical	clinical	JJ
cord-253295-82ydczid	1	18	description	description	NN
cord-253295-82ydczid	1	19	of	of	IN
cord-253295-82ydczid	1	20	human	human	JJ
cord-253295-82ydczid	1	21	disease	disease	NN
cord-253295-82ydczid	1	22	date	date	NN
cord-253295-82ydczid	1	23	:	:	:
cord-253295-82ydczid	1	24	2020	2020	CD
cord-253295-82ydczid	1	25	-	-	HYPH
cord-253295-82ydczid	1	26	07	07	CD
cord-253295-82ydczid	1	27	-	-	HYPH
cord-253295-82ydczid	1	28	24	24	CD
cord-253295-82ydczid	1	29	journal	journal	NN
cord-253295-82ydczid	1	30	:	:	:
cord-253295-82ydczid	1	31	Essential	essential	JJ
cord-253295-82ydczid	1	32	Concepts	Concepts	NNPS
cord-253295-82ydczid	1	33	in	in	IN
cord-253295-82ydczid	1	34	Molecular	Molecular	NNP
cord-253295-82ydczid	1	35	Pathology	Pathology	NNP
cord-253295-82ydczid	2	1	DOI	DOI	NNP
cord-253295-82ydczid	2	2	:	:	:
cord-253295-82ydczid	3	1	10.1016	10.1016	CD
cord-253295-82ydczid	3	2	/	/	SYM
cord-253295-82ydczid	3	3	b978	b978	NN
cord-253295-82ydczid	3	4	-	-	HYPH
cord-253295-82ydczid	3	5	0	0	CD
cord-253295-82ydczid	3	6	-	-	HYPH
cord-253295-82ydczid	3	7	12	12	CD
cord-253295-82ydczid	3	8	-	-	HYPH
cord-253295-82ydczid	3	9	813257	813257	CD
cord-253295-82ydczid	3	10	-	-	HYPH
cord-253295-82ydczid	3	11	9.00011	9.00011	CD
cord-253295-82ydczid	3	12	-	-	SYM
cord-253295-82ydczid	3	13	5	5	CD
cord-253295-82ydczid	3	14	sha	sha	NNP
cord-253295-82ydczid	3	15	:	:	:
cord-253295-82ydczid	4	1	7077fd13905708c20ca35f3d5407fc346126815f	7077fd13905708c20ca35f3d5407fc346126815f	CD
cord-253295-82ydczid	4	2	doc_id	doc_id	CD
cord-253295-82ydczid	4	3	:	:	:
cord-253295-82ydczid	4	4	253295	253295	CD
cord-253295-82ydczid	4	5	cord_uid	cord_uid	NNS
cord-253295-82ydczid	4	6	:	:	:
cord-253295-82ydczid	5	1	82ydczid	82ydczid	CD
cord-253295-82ydczid	5	2	Pathology	Pathology	NNP
cord-253295-82ydczid	5	3	is	be	VBZ
cord-253295-82ydczid	5	4	that	that	DT
cord-253295-82ydczid	5	5	field	field	NN
cord-253295-82ydczid	5	6	of	of	IN
cord-253295-82ydczid	5	7	science	science	NN
cord-253295-82ydczid	5	8	and	and	CC
cord-253295-82ydczid	5	9	medicine	medicine	NN
cord-253295-82ydczid	5	10	concerned	concern	VBN
cord-253295-82ydczid	5	11	with	with	IN
cord-253295-82ydczid	5	12	the	the	DT
cord-253295-82ydczid	5	13	study	study	NN
cord-253295-82ydczid	5	14	of	of	IN
cord-253295-82ydczid	5	15	diseases	disease	NNS
cord-253295-82ydczid	5	16	,	,	,
cord-253295-82ydczid	5	17	specifically	specifically	RB
cord-253295-82ydczid	5	18	their	-PRON-	PRP$
cord-253295-82ydczid	5	19	initial	initial	JJ
cord-253295-82ydczid	5	20	causes	cause	NNS
cord-253295-82ydczid	5	21	(	(	-LRB-
cord-253295-82ydczid	5	22	etiologies	etiology	NNS
cord-253295-82ydczid	5	23	)	)	-RRB-
cord-253295-82ydczid	5	24	,	,	,
cord-253295-82ydczid	5	25	their	-PRON-	PRP$
cord-253295-82ydczid	5	26	step	step	NN
cord-253295-82ydczid	5	27	-	-	HYPH
cord-253295-82ydczid	5	28	wise	wise	JJ
cord-253295-82ydczid	5	29	progressions	progression	NNS
cord-253295-82ydczid	5	30	(	(	-LRB-
cord-253295-82ydczid	5	31	pathogenesis	pathogenesis	NN
cord-253295-82ydczid	5	32	)	)	-RRB-
cord-253295-82ydczid	5	33	,	,	,
cord-253295-82ydczid	5	34	and	and	CC
cord-253295-82ydczid	5	35	their	-PRON-	PRP$
cord-253295-82ydczid	5	36	effects	effect	NNS
cord-253295-82ydczid	5	37	on	on	IN
cord-253295-82ydczid	5	38	normal	normal	JJ
cord-253295-82ydczid	5	39	structure	structure	NN
cord-253295-82ydczid	5	40	and	and	CC
cord-253295-82ydczid	5	41	function	function	NN
cord-253295-82ydczid	5	42	.	.	.
cord-253295-82ydczid	6	1	This	this	DT
cord-253295-82ydczid	6	2	chapter	chapter	NN
cord-253295-82ydczid	6	3	will	will	MD
cord-253295-82ydczid	6	4	consider	consider	VB
cord-253295-82ydczid	6	5	the	the	DT
cord-253295-82ydczid	6	6	history	history	NN
cord-253295-82ydczid	6	7	of	of	IN
cord-253295-82ydczid	6	8	relevant	relevant	JJ
cord-253295-82ydczid	6	9	discoveries	discovery	NNS
cord-253295-82ydczid	6	10	and	and	CC
cord-253295-82ydczid	6	11	technologies	technology	NNS
cord-253295-82ydczid	6	12	that	that	WDT
cord-253295-82ydczid	6	13	have	have	VBP
cord-253295-82ydczid	6	14	led	lead	VBN
cord-253295-82ydczid	6	15	to	to	IN
cord-253295-82ydczid	6	16	our	-PRON-	PRP$
cord-253295-82ydczid	6	17	current	current	JJ
cord-253295-82ydczid	6	18	understanding	understanding	NN
cord-253295-82ydczid	6	19	of	of	IN
cord-253295-82ydczid	6	20	diseases	disease	NNS
cord-253295-82ydczid	6	21	,	,	,
cord-253295-82ydczid	6	22	as	as	RB
cord-253295-82ydczid	6	23	well	well	RB
cord-253295-82ydczid	6	24	as	as	IN
cord-253295-82ydczid	6	25	the	the	DT
cord-253295-82ydczid	6	26	Pathologist	Pathologist	NNP
cord-253295-82ydczid	6	27	’s	’s	POS
cord-253295-82ydczid	6	28	current	current	JJ
cord-253295-82ydczid	6	29	role	role	NN
cord-253295-82ydczid	6	30	in	in	IN
cord-253295-82ydczid	6	31	the	the	DT
cord-253295-82ydczid	6	32	diagnosis	diagnosis	NN
cord-253295-82ydczid	6	33	,	,	,
cord-253295-82ydczid	6	34	prognosis	prognosis	NN
cord-253295-82ydczid	6	35	,	,	,
cord-253295-82ydczid	6	36	and	and	CC
cord-253295-82ydczid	6	37	prediction	prediction	NN
cord-253295-82ydczid	6	38	of	of	IN
cord-253295-82ydczid	6	39	response	response	NN
cord-253295-82ydczid	6	40	of	of	IN
cord-253295-82ydczid	6	41	human	human	JJ
cord-253295-82ydczid	6	42	diseases	disease	NNS
cord-253295-82ydczid	6	43	.	.	.
cord-253295-82ydczid	7	1	This	this	DT
cord-253295-82ydczid	7	2	chapter	chapter	NN
cord-253295-82ydczid	7	3	will	will	MD
cord-253295-82ydczid	7	4	discuss	discuss	VB
cord-253295-82ydczid	7	5	the	the	DT
cord-253295-82ydczid	7	6	fundamental	fundamental	JJ
cord-253295-82ydczid	7	7	concepts	concept	NNS
cord-253295-82ydczid	7	8	,	,	,
cord-253295-82ydczid	7	9	terminology	terminology	NN
cord-253295-82ydczid	7	10	,	,	,
cord-253295-82ydczid	7	11	and	and	CC
cord-253295-82ydczid	7	12	practice	practice	NN
cord-253295-82ydczid	7	13	of	of	IN
cord-253295-82ydczid	7	14	pathology	pathology	NN
cord-253295-82ydczid	7	15	as	as	IN
cord-253295-82ydczid	7	16	the	the	DT
cord-253295-82ydczid	7	17	discipline	discipline	NN
cord-253295-82ydczid	7	18	dedicated	dedicate	VBN
cord-253295-82ydczid	7	19	to	to	IN
cord-253295-82ydczid	7	20	the	the	DT
cord-253295-82ydczid	7	21	understanding	understanding	NN
cord-253295-82ydczid	7	22	of	of	IN
cord-253295-82ydczid	7	23	causes	cause	NNS
cord-253295-82ydczid	7	24	,	,	,
cord-253295-82ydczid	7	25	mechanisms	mechanism	NNS
cord-253295-82ydczid	7	26	,	,	,
cord-253295-82ydczid	7	27	and	and	CC
cord-253295-82ydczid	7	28	effects	effect	NNS
cord-253295-82ydczid	7	29	of	of	IN
cord-253295-82ydczid	7	30	diseases	disease	NNS
cord-253295-82ydczid	7	31	.	.	.
cord-253295-82ydczid	8	1	A	a	DT
cord-253295-82ydczid	8	2	section	section	NN
cord-253295-82ydczid	8	3	on	on	IN
cord-253295-82ydczid	8	4	key	key	JJ
cord-253295-82ydczid	8	5	terms	term	NNS
cord-253295-82ydczid	8	6	,	,	,
cord-253295-82ydczid	8	7	definitions	definition	NNS
cord-253295-82ydczid	8	8	,	,	,
cord-253295-82ydczid	8	9	and	and	CC
cord-253295-82ydczid	8	10	concepts	concept	NNS
cord-253295-82ydczid	8	11	is	be	VBZ
cord-253295-82ydczid	8	12	followed	follow	VBN
cord-253295-82ydczid	8	13	by	by	IN
cord-253295-82ydczid	8	14	sections	section	NNS
cord-253295-82ydczid	8	15	on	on	IN
cord-253295-82ydczid	8	16	historical	historical	JJ
cord-253295-82ydczid	8	17	human	human	JJ
cord-253295-82ydczid	8	18	approaches	approach	NNS
cord-253295-82ydczid	8	19	to	to	IN
cord-253295-82ydczid	8	20	diseases	disease	NNS
cord-253295-82ydczid	8	21	,	,	,
cord-253295-82ydczid	8	22	an	an	DT
cord-253295-82ydczid	8	23	overview	overview	NN
cord-253295-82ydczid	8	24	of	of	IN
cord-253295-82ydczid	8	25	current	current	JJ
cord-253295-82ydczid	8	26	diagnostic	diagnostic	JJ
cord-253295-82ydczid	8	27	practice	practice	NN
cord-253295-82ydczid	8	28	,	,	,
cord-253295-82ydczid	8	29	and	and	CC
cord-253295-82ydczid	8	30	a	a	DT
cord-253295-82ydczid	8	31	vision	vision	NN
cord-253295-82ydczid	8	32	for	for	IN
cord-253295-82ydczid	8	33	new	new	JJ
cord-253295-82ydczid	8	34	interface	interface	NN
cord-253295-82ydczid	8	35	with	with	IN
cord-253295-82ydczid	8	36	applied	apply	VBN
cord-253295-82ydczid	8	37	molecular	molecular	JJ
cord-253295-82ydczid	8	38	biology	biology	NN
cord-253295-82ydczid	8	39	.	.	.
cord-253295-82ydczid	9	1	Pathology	pathology	NN
cord-253295-82ydczid	9	2	(	(	-LRB-
cord-253295-82ydczid	9	3	from	from	IN
cord-253295-82ydczid	9	4	the	the	DT
cord-253295-82ydczid	9	5	Greek	greek	JJ
cord-253295-82ydczid	9	6	word	word	NN
cord-253295-82ydczid	9	7	pathologı´a	pathologı´a	NNP
cord-253295-82ydczid	9	8	,	,	,
cord-253295-82ydczid	9	9	meaning	mean	VBG
cord-253295-82ydczid	9	10	the	the	DT
cord-253295-82ydczid	9	11	study	study	NN
cord-253295-82ydczid	9	12	of	of	IN
cord-253295-82ydczid	9	13	suffering	suffering	NN
cord-253295-82ydczid	9	14	)	)	-RRB-
cord-253295-82ydczid	9	15	refers	refer	VBZ
cord-253295-82ydczid	9	16	to	to	IN
cord-253295-82ydczid	9	17	the	the	DT
cord-253295-82ydczid	9	18	specialty	specialty	NN
cord-253295-82ydczid	9	19	of	of	IN
cord-253295-82ydczid	9	20	medical	medical	JJ
cord-253295-82ydczid	9	21	science	science	NN
cord-253295-82ydczid	9	22	concerned	concern	VBN
cord-253295-82ydczid	9	23	with	with	IN
cord-253295-82ydczid	9	24	the	the	DT
cord-253295-82ydczid	9	25	cause	cause	NN
cord-253295-82ydczid	9	26	,	,	,
cord-253295-82ydczid	9	27	development	development	NN
cord-253295-82ydczid	9	28	,	,	,
cord-253295-82ydczid	9	29	structural	structural	JJ
cord-253295-82ydczid	9	30	/	/	SYM
cord-253295-82ydczid	9	31	functional	functional	JJ
cord-253295-82ydczid	9	32	changes	change	NNS
cord-253295-82ydczid	9	33	,	,	,
cord-253295-82ydczid	9	34	and	and	CC
cord-253295-82ydczid	9	35	natural	natural	JJ
cord-253295-82ydczid	9	36	history	history	NN
cord-253295-82ydczid	9	37	associated	associate	VBN
cord-253295-82ydczid	9	38	with	with	IN
cord-253295-82ydczid	9	39	diseases	disease	NNS
cord-253295-82ydczid	9	40	.	.	.
cord-253295-82ydczid	10	1	Disease	Disease	NNP
cord-253295-82ydczid	10	2	refers	refer	VBZ
cord-253295-82ydczid	10	3	to	to	IN
cord-253295-82ydczid	10	4	a	a	DT
cord-253295-82ydczid	10	5	definable	definable	JJ
cord-253295-82ydczid	10	6	deviation	deviation	NN
cord-253295-82ydczid	10	7	from	from	IN
cord-253295-82ydczid	10	8	a	a	DT
cord-253295-82ydczid	10	9	normal	normal	JJ
cord-253295-82ydczid	10	10	phenotype	phenotype	NN
cord-253295-82ydczid	10	11	(	(	-LRB-
cord-253295-82ydczid	10	12	observable	observable	JJ
cord-253295-82ydczid	10	13	characteristics	characteristic	NNS
cord-253295-82ydczid	10	14	due	due	JJ
cord-253295-82ydczid	10	15	to	to	IN
cord-253295-82ydczid	10	16	genome	genome	NN
cord-253295-82ydczid	10	17	and	and	CC
cord-253295-82ydczid	10	18	environment	environment	NN
cord-253295-82ydczid	10	19	)	)	-RRB-
cord-253295-82ydczid	10	20	,	,	.
cord-253295-82ydczid	11	1	evident	evident	JJ
cord-253295-82ydczid	11	2	via	via	IN
cord-253295-82ydczid	11	3	patient	patient	JJ
cord-253295-82ydczid	11	4	complaints	complaint	NNS
cord-253295-82ydczid	11	5	(	(	-LRB-
cord-253295-82ydczid	11	6	symptoms	symptom	NNS
cord-253295-82ydczid	11	7	)	)	-RRB-
cord-253295-82ydczid	11	8	,	,	,
cord-253295-82ydczid	11	9	and/or	and/or	CC
cord-253295-82ydczid	11	10	the	the	DT
cord-253295-82ydczid	11	11	measurements	measurement	NNS
cord-253295-82ydczid	11	12	of	of	IN
cord-253295-82ydczid	11	13	a	a	DT
cord-253295-82ydczid	11	14	careful	careful	JJ
cord-253295-82ydczid	11	15	observer	observer	NN
cord-253295-82ydczid	11	16	(	(	-LRB-
cord-253295-82ydczid	11	17	signs	sign	NNS
cord-253295-82ydczid	11	18	)	)	-RRB-
cord-253295-82ydczid	11	19	.	.	.
cord-253295-82ydczid	12	1	The	the	DT
cord-253295-82ydczid	12	2	cause	cause	NN
cord-253295-82ydczid	12	3	of	of	IN
cord-253295-82ydczid	12	4	the	the	DT
cord-253295-82ydczid	12	5	disease	disease	NN
cord-253295-82ydczid	12	6	is	be	VBZ
cord-253295-82ydczid	12	7	referred	refer	VBN
cord-253295-82ydczid	12	8	to	to	IN
cord-253295-82ydczid	12	9	as	as	IN
cord-253295-82ydczid	12	10	its	-PRON-	PRP$
cord-253295-82ydczid	12	11	etiology	etiology	NN
cord-253295-82ydczid	12	12	(	(	-LRB-
cord-253295-82ydczid	12	13	from	from	IN
cord-253295-82ydczid	12	14	the	the	DT
cord-253295-82ydczid	12	15	Greek	greek	JJ
cord-253295-82ydczid	12	16	word	word	NN
cord-253295-82ydczid	12	17	meaning	mean	VBG
cord-253295-82ydczid	12	18	the	the	DT
cord-253295-82ydczid	12	19	study	study	NN
cord-253295-82ydczid	12	20	of	of	IN
cord-253295-82ydczid	12	21	cause	cause	NN
cord-253295-82ydczid	12	22	)	)	-RRB-
cord-253295-82ydczid	12	23	.	.	.
cord-253295-82ydczid	13	1	One	one	CD
cord-253295-82ydczid	13	2	disease	disease	NN
cord-253295-82ydczid	13	3	entity	entity	NN
cord-253295-82ydczid	13	4	can	can	MD
cord-253295-82ydczid	13	5	have	have	VB
cord-253295-82ydczid	13	6	more	more	JJR
cord-253295-82ydczid	13	7	than	than	IN
cord-253295-82ydczid	13	8	one	one	CD
cord-253295-82ydczid	13	9	etiology	etiology	NN
cord-253295-82ydczid	13	10	,	,	,
cord-253295-82ydczid	13	11	and	and	CC
cord-253295-82ydczid	13	12	one	one	CD
cord-253295-82ydczid	13	13	etiology	etiology	NN
cord-253295-82ydczid	13	14	can	can	MD
cord-253295-82ydczid	13	15	lead	lead	VB
cord-253295-82ydczid	13	16	to	to	IN
cord-253295-82ydczid	13	17	more	more	JJR
cord-253295-82ydczid	13	18	than	than	IN
cord-253295-82ydczid	13	19	one	one	CD
cord-253295-82ydczid	13	20	disease	disease	NN
cord-253295-82ydczid	13	21	.	.	.
cord-253295-82ydczid	14	1	Each	each	DT
cord-253295-82ydczid	14	2	disease	disease	NN
cord-253295-82ydczid	14	3	entity	entity	NN
cord-253295-82ydczid	14	4	develops	develop	VBZ
cord-253295-82ydczid	14	5	through	through	IN
cord-253295-82ydczid	14	6	a	a	DT
cord-253295-82ydczid	14	7	series	series	NN
cord-253295-82ydczid	14	8	of	of	IN
cord-253295-82ydczid	14	9	mechanistic	mechanistic	JJ
cord-253295-82ydczid	14	10	chemical	chemical	NN
cord-253295-82ydczid	14	11	and	and	CC
cord-253295-82ydczid	14	12	cellular	cellular	JJ
cord-253295-82ydczid	14	13	steps	step	NNS
cord-253295-82ydczid	14	14	.	.	.
cord-253295-82ydczid	15	1	This	this	DT
cord-253295-82ydczid	15	2	stepwise	stepwise	JJ
cord-253295-82ydczid	15	3	process	process	NN
cord-253295-82ydczid	15	4	of	of	IN
cord-253295-82ydczid	15	5	disease	disease	NN
cord-253295-82ydczid	15	6	development	development	NN
cord-253295-82ydczid	15	7	is	be	VBZ
cord-253295-82ydczid	15	8	referred	refer	VBN
cord-253295-82ydczid	15	9	to	to	IN
cord-253295-82ydczid	15	10	as	as	IN
cord-253295-82ydczid	15	11	its	-PRON-	PRP$
cord-253295-82ydczid	15	12	pathogenesis	pathogenesis	NN
cord-253295-82ydczid	15	13	(	(	-LRB-
cord-253295-82ydczid	15	14	from	from	IN
cord-253295-82ydczid	15	15	the	the	DT
cord-253295-82ydczid	15	16	Greek	greek	JJ
cord-253295-82ydczid	15	17	word	word	NN
cord-253295-82ydczid	15	18	meaning	mean	VBG
cord-253295-82ydczid	15	19	generation	generation	NN
cord-253295-82ydczid	15	20	of	of	IN
cord-253295-82ydczid	15	21	suffering	suffering	NN
cord-253295-82ydczid	15	22	)	)	-RRB-
cord-253295-82ydczid	15	23	.	.	.
cord-253295-82ydczid	16	1	Pathogenesis	Pathogenesis	NNP
cord-253295-82ydczid	16	2	can	can	MD
cord-253295-82ydczid	16	3	refer	refer	VB
cord-253295-82ydczid	16	4	to	to	IN
cord-253295-82ydczid	16	5	the	the	DT
cord-253295-82ydczid	16	6	changes	change	NNS
cord-253295-82ydczid	16	7	in	in	IN
cord-253295-82ydczid	16	8	the	the	DT
cord-253295-82ydczid	16	9	structure	structure	NN
cord-253295-82ydczid	16	10	or	or	CC
cord-253295-82ydczid	16	11	function	function	NN
cord-253295-82ydczid	16	12	of	of	IN
cord-253295-82ydczid	16	13	an	an	DT
cord-253295-82ydczid	16	14	organism	organism	NN
cord-253295-82ydczid	16	15	at	at	IN
cord-253295-82ydczid	16	16	the	the	DT
cord-253295-82ydczid	16	17	gross	gross	JJ
cord-253295-82ydczid	16	18	/	/	SYM
cord-253295-82ydczid	16	19	clinical	clinical	JJ
cord-253295-82ydczid	16	20	level	level	NN
cord-253295-82ydczid	16	21	,	,	,
cord-253295-82ydczid	16	22	and	and	CC
cord-253295-82ydczid	16	23	it	-PRON-	PRP
cord-253295-82ydczid	16	24	can	can	MD
cord-253295-82ydczid	16	25	refer	refer	VB
cord-253295-82ydczid	16	26	to	to	IN
cord-253295-82ydczid	16	27	the	the	DT
cord-253295-82ydczid	16	28	stepwise	stepwise	JJ
cord-253295-82ydczid	16	29	molecular	molecular	JJ
cord-253295-82ydczid	16	30	abnormalities	abnormality	NNS
cord-253295-82ydczid	16	31	leading	lead	VBG
cord-253295-82ydczid	16	32	to	to	IN
cord-253295-82ydczid	16	33	changes	change	NNS
cord-253295-82ydczid	16	34	in	in	IN
cord-253295-82ydczid	16	35	cellular	cellular	JJ
cord-253295-82ydczid	16	36	and	and	CC
cord-253295-82ydczid	16	37	tissue	tissue	NN
cord-253295-82ydczid	16	38	function	function	NN
cord-253295-82ydczid	16	39	.	.	.
cord-253295-82ydczid	17	1	The	the	DT
cord-253295-82ydczid	17	2	presentation	presentation	NN
cord-253295-82ydczid	17	3	of	of	IN
cord-253295-82ydczid	17	4	a	a	DT
cord-253295-82ydczid	17	5	disease	disease	NN
cord-253295-82ydczid	17	6	to	to	IN
cord-253295-82ydczid	17	7	a	a	DT
cord-253295-82ydczid	17	8	clinician	clinician	NN
cord-253295-82ydczid	17	9	is	be	VBZ
cord-253295-82ydczid	17	10	in	in	IN
cord-253295-82ydczid	17	11	the	the	DT
cord-253295-82ydczid	17	12	form	form	NN
cord-253295-82ydczid	17	13	of	of	IN
cord-253295-82ydczid	17	14	a	a	DT
cord-253295-82ydczid	17	15	human	human	JJ
cord-253295-82ydczid	17	16	patient	patient	NN
cord-253295-82ydczid	17	17	with	with	IN
cord-253295-82ydczid	17	18	variably	variably	RB
cord-253295-82ydczid	17	19	specific	specific	JJ
cord-253295-82ydczid	17	20	complaints	complaint	NNS
cord-253295-82ydczid	17	21	(	(	-LRB-
cord-253295-82ydczid	17	22	symptoms	symptom	NNS
cord-253295-82ydczid	17	23	)	)	-RRB-
cord-253295-82ydczid	17	24	,	,	,
cord-253295-82ydczid	17	25	to	to	TO
cord-253295-82ydczid	17	26	which	which	WDT
cord-253295-82ydczid	17	27	the	the	DT
cord-253295-82ydczid	17	28	examining	examine	VBG
cord-253295-82ydczid	17	29	physicians	physician	NNS
cord-253295-82ydczid	17	30	can	can	MD
cord-253295-82ydczid	17	31	add	add	VB
cord-253295-82ydczid	17	32	diagnostic	diagnostic	JJ
cord-253295-82ydczid	17	33	sensitivity	sensitivity	NN
cord-253295-82ydczid	17	34	and	and	CC
cord-253295-82ydczid	17	35	specificity	specificity	NN
cord-253295-82ydczid	17	36	by	by	IN
cord-253295-82ydczid	17	37	making	make	VBG
cord-253295-82ydczid	17	38	observations	observation	NNS
cord-253295-82ydczid	17	39	(	(	-LRB-
cord-253295-82ydczid	17	40	screening	screen	VBG
cord-253295-82ydczid	17	41	for	for	IN
cord-253295-82ydczid	17	42	signs	sign	NNS
cord-253295-82ydczid	17	43	of	of	IN
cord-253295-82ydczid	17	44	diseases	disease	NNS
cord-253295-82ydczid	17	45	)	)	-RRB-
cord-253295-82ydczid	17	46	.	.	.
cord-253295-82ydczid	18	1	These	these	DT
cord-253295-82ydczid	18	2	phenotypic	phenotypic	NNS
cord-253295-82ydczid	18	3	(	(	-LRB-
cord-253295-82ydczid	18	4	measurable	measurable	JJ
cord-253295-82ydczid	18	5	characteristic	characteristic	NN
cord-253295-82ydczid	18	6	)	)	-RRB-
cord-253295-82ydczid	18	7	abnormalities	abnormality	NNS
cord-253295-82ydczid	18	8	reflect	reflect	VBP
cord-253295-82ydczid	18	9	the	the	DT
cord-253295-82ydczid	18	10	interaction	interaction	NN
cord-253295-82ydczid	18	11	of	of	IN
cord-253295-82ydczid	18	12	the	the	DT
cord-253295-82ydczid	18	13	genotype	genotype	NN
cord-253295-82ydczid	18	14	(	(	-LRB-
cord-253295-82ydczid	18	15	cytogenetic	cytogenetic	JJ
cord-253295-82ydczid	18	16	and	and	CC
cord-253295-82ydczid	18	17	nucleic	nucleic	JJ
cord-253295-82ydczid	18	18	acid	acid	NN
cord-253295-82ydczid	18	19	sequence	sequence	NN
cord-253295-82ydczid	18	20	/	/	SYM
cord-253295-82ydczid	18	21	expression	expression	NN
cord-253295-82ydczid	18	22	)	)	-RRB-
cord-253295-82ydczid	18	23	of	of	IN
cord-253295-82ydczid	18	24	the	the	DT
cord-253295-82ydczid	18	25	patient	patient	NN
cord-253295-82ydczid	18	26	and	and	CC
cord-253295-82ydczid	18	27	his	-PRON-	PRP$
cord-253295-82ydczid	18	28	/	/	SYM
cord-253295-82ydczid	18	29	her	-PRON-	PRP$
cord-253295-82ydczid	18	30	environment	environment	NN
cord-253295-82ydczid	18	31	.	.	.
cord-253295-82ydczid	19	1	Patient	patient	JJ
cord-253295-82ydczid	19	2	workup	workup	NN
cord-253295-82ydczid	19	3	uses	use	VBZ
cord-253295-82ydczid	19	4	present	present	JJ
cord-253295-82ydczid	19	5	illness	illness	NN
cord-253295-82ydczid	19	6	history	history	NN
cord-253295-82ydczid	19	7	with	with	IN
cord-253295-82ydczid	19	8	reference	reference	NN
cord-253295-82ydczid	19	9	to	to	IN
cord-253295-82ydczid	19	10	past	past	JJ
cord-253295-82ydczid	19	11	medical	medical	JJ
cord-253295-82ydczid	19	12	history	history	NN
cord-253295-82ydczid	19	13	,	,	,
cord-253295-82ydczid	19	14	review	review	NN
cord-253295-82ydczid	19	15	of	of	IN
cord-253295-82ydczid	19	16	other	other	JJ
cord-253295-82ydczid	19	17	organ	organ	NN
cord-253295-82ydczid	19	18	systems	system	NNS
cord-253295-82ydczid	19	19	for	for	IN
cord-253295-82ydczid	19	20	other	other	JJ
cord-253295-82ydczid	19	21	abnormalities	abnormality	NNS
cord-253295-82ydczid	19	22	,	,	,
cord-253295-82ydczid	19	23	review	review	NN
cord-253295-82ydczid	19	24	of	of	IN
cord-253295-82ydczid	19	25	family	family	NN
cord-253295-82ydczid	19	26	history	history	NN
cord-253295-82ydczid	19	27	,	,	,
cord-253295-82ydczid	19	28	physical	physical	JJ
cord-253295-82ydczid	19	29	examination	examination	NN
cord-253295-82ydczid	19	30	,	,	,
cord-253295-82ydczid	19	31	radiographic	radiographic	JJ
cord-253295-82ydczid	19	32	studies	study	NNS
cord-253295-82ydczid	19	33	,	,	,
cord-253295-82ydczid	19	34	clinical	clinical	JJ
cord-253295-82ydczid	19	35	laboratory	laboratory	NN
cord-253295-82ydczid	19	36	studies	study	NNS
cord-253295-82ydczid	19	37	(	(	-LRB-
cord-253295-82ydczid	19	38	for	for	IN
cord-253295-82ydczid	19	39	example	example	NN
cord-253295-82ydczid	19	40	,	,	,
cord-253295-82ydczid	19	41	peripheral	peripheral	JJ
cord-253295-82ydczid	19	42	blood	blood	NN
cord-253295-82ydczid	19	43	or	or	CC
cord-253295-82ydczid	19	44	CSF	csf	NN
cord-253295-82ydczid	19	45	specimens	specimen	NNS
cord-253295-82ydczid	19	46	)	)	-RRB-
cord-253295-82ydczid	19	47	,	,	,
cord-253295-82ydczid	19	48	and	and	CC
cord-253295-82ydczid	19	49	anatomic	anatomic	JJ
cord-253295-82ydczid	19	50	pathology	pathology	NN
cord-253295-82ydczid	19	51	laboratory	laboratory	NN
cord-253295-82ydczid	19	52	studies	study	NNS
cord-253295-82ydczid	19	53	(	(	-LRB-
cord-253295-82ydczid	19	54	for	for	IN
cord-253295-82ydczid	19	55	example	example	NN
cord-253295-82ydczid	19	56	,	,	,
cord-253295-82ydczid	19	57	tissue	tissue	NN
cord-253295-82ydczid	19	58	biopsy	biopsy	NN
cord-253295-82ydczid	19	59	or	or	CC
cord-253295-82ydczid	19	60	pleural	pleural	JJ
cord-253295-82ydczid	19	61	fluid	fluid	NN
cord-253295-82ydczid	19	62	cytology	cytology	NN
cord-253295-82ydczid	19	63	specimens	specimen	NNS
cord-253295-82ydczid	19	64	)	)	-RRB-
cord-253295-82ydczid	19	65	.	.	.
cord-253295-82ydczid	20	1	As	as	IN
cord-253295-82ydczid	20	2	you	-PRON-	PRP
cord-253295-82ydczid	20	3	will	will	MD
cord-253295-82ydczid	20	4	see	see	VB
cord-253295-82ydczid	20	5	from	from	IN
cord-253295-82ydczid	20	6	other	other	JJ
cord-253295-82ydczid	20	7	chapters	chapter	NNS
cord-253295-82ydczid	20	8	in	in	IN
cord-253295-82ydczid	20	9	this	this	DT
cord-253295-82ydczid	20	10	book	book	NN
cord-253295-82ydczid	20	11	,	,	,
cord-253295-82ydczid	20	12	the	the	DT
cord-253295-82ydczid	20	13	ability	ability	NN
cord-253295-82ydczid	20	14	to	to	TO
cord-253295-82ydczid	20	15	rapidly	rapidly	RB
cord-253295-82ydczid	20	16	and	and	CC
cord-253295-82ydczid	20	17	inexpensively	inexpensively	RB
cord-253295-82ydczid	20	18	screen	screen	NN
cord-253295-82ydczid	20	19	for	for	IN
cord-253295-82ydczid	20	20	chromosomal	chromosomal	JJ
cord-253295-82ydczid	20	21	translocations	translocation	NNS
cord-253295-82ydczid	20	22	,	,	,
cord-253295-82ydczid	20	23	copy	copy	VBP
cord-253295-82ydczid	21	1	number	number	NN
cord-253295-82ydczid	21	2	variation	variation	NN
cord-253295-82ydczid	21	3	,	,	,
cord-253295-82ydczid	21	4	genetic	genetic	JJ
cord-253295-82ydczid	21	5	variation	variation	NN
cord-253295-82ydczid	21	6	,	,	,
cord-253295-82ydczid	21	7	and	and	CC
cord-253295-82ydczid	21	8	abundance	abundance	NN
cord-253295-82ydczid	21	9	of	of	IN
cord-253295-82ydczid	21	10	mRNA	mRNA	NNP
cord-253295-82ydczid	21	11	and	and	CC
cord-253295-82ydczid	21	12	miRNA	miRNA	NNP
cord-253295-82ydczid	21	13	is	be	VBZ
cord-253295-82ydczid	21	14	adding	add	VBG
cord-253295-82ydczid	21	15	substantial	substantial	JJ
cord-253295-82ydczid	21	16	molecular	molecular	JJ
cord-253295-82ydczid	21	17	correlative	correlative	JJ
cord-253295-82ydczid	21	18	information	information	NN
cord-253295-82ydczid	21	19	to	to	IN
cord-253295-82ydczid	21	20	the	the	DT
cord-253295-82ydczid	21	21	workup	workup	NN
cord-253295-82ydczid	21	22	of	of	IN
cord-253295-82ydczid	21	23	diseases	disease	NNS
cord-253295-82ydczid	21	24	.	.	.
cord-253295-82ydczid	22	1	The	the	DT
cord-253295-82ydczid	22	2	differential	differential	JJ
cord-253295-82ydczid	22	3	diagnosis	diagnosis	NN
cord-253295-82ydczid	22	4	represents	represent	VBZ
cord-253295-82ydczid	22	5	the	the	DT
cord-253295-82ydczid	22	6	set	set	NN
cord-253295-82ydczid	22	7	of	of	IN
cord-253295-82ydczid	22	8	possible	possible	JJ
cord-253295-82ydczid	22	9	diagnoses	diagnosis	NNS
cord-253295-82ydczid	22	10	that	that	WDT
cord-253295-82ydczid	22	11	could	could	MD
cord-253295-82ydczid	22	12	account	account	VB
cord-253295-82ydczid	22	13	for	for	IN
cord-253295-82ydczid	22	14	symptoms	symptom	NNS
cord-253295-82ydczid	22	15	and	and	CC
cord-253295-82ydczid	22	16	signs	sign	NNS
cord-253295-82ydczid	22	17	associated	associate	VBN
cord-253295-82ydczid	22	18	with	with	IN
cord-253295-82ydczid	22	19	the	the	DT
cord-253295-82ydczid	22	20	condition	condition	NN
cord-253295-82ydczid	22	21	of	of	IN
cord-253295-82ydczid	22	22	the	the	DT
cord-253295-82ydczid	22	23	patient	patient	NN
cord-253295-82ydczid	22	24	.	.	.
cord-253295-82ydczid	23	1	The	the	DT
cord-253295-82ydczid	23	2	conclusion	conclusion	NN
cord-253295-82ydczid	23	3	of	of	IN
cord-253295-82ydczid	23	4	the	the	DT
cord-253295-82ydczid	23	5	workup	workup	NN
cord-253295-82ydczid	23	6	generally	generally	RB
cord-253295-82ydczid	23	7	results	result	VBZ
cord-253295-82ydczid	23	8	in	in	IN
cord-253295-82ydczid	23	9	a	a	DT
cord-253295-82ydczid	23	10	specific	specific	JJ
cord-253295-82ydczid	23	11	diagnosis	diagnosis	NN
cord-253295-82ydczid	23	12	which	which	WDT
cord-253295-82ydczid	23	13	meets	meet	VBZ
cord-253295-82ydczid	23	14	a	a	DT
cord-253295-82ydczid	23	15	set	set	NN
cord-253295-82ydczid	23	16	of	of	IN
cord-253295-82ydczid	23	17	diagnostic	diagnostic	JJ
cord-253295-82ydczid	23	18	criteria	criterion	NNS
cord-253295-82ydczid	23	19	,	,	,
cord-253295-82ydczid	23	20	and	and	CC
cord-253295-82ydczid	23	21	which	which	WDT
cord-253295-82ydczid	23	22	explains	explain	VBZ
cord-253295-82ydczid	23	23	the	the	DT
cord-253295-82ydczid	23	24	patient	patient	NN
cord-253295-82ydczid	23	25	's	's	POS
cord-253295-82ydczid	23	26	symptoms	symptom	NNS
cord-253295-82ydczid	23	27	and	and	CC
cord-253295-82ydczid	23	28	phenotypic	phenotypic	JJ
cord-253295-82ydczid	23	29	abnormalities	abnormality	NNS
cord-253295-82ydczid	23	30	.	.	.
cord-253295-82ydczid	24	1	Obviously	obviously	RB
cord-253295-82ydczid	24	2	,	,	,
cord-253295-82ydczid	24	3	arrival	arrival	NN
cord-253295-82ydczid	24	4	at	at	IN
cord-253295-82ydczid	24	5	the	the	DT
cord-253295-82ydczid	24	6	correct	correct	JJ
cord-253295-82ydczid	24	7	diagnosis	diagnosis	NN
cord-253295-82ydczid	24	8	is	be	VBZ
cord-253295-82ydczid	24	9	a	a	DT
cord-253295-82ydczid	24	10	function	function	NN
cord-253295-82ydczid	24	11	of	of	IN
cord-253295-82ydczid	24	12	the	the	DT
cord-253295-82ydczid	24	13	examining	examine	VBG
cord-253295-82ydczid	24	14	physician	physician	NN
cord-253295-82ydczid	24	15	and	and	CC
cord-253295-82ydczid	24	16	pathologist	pathologist	NN
cord-253295-82ydczid	24	17	(	(	-LRB-
cord-253295-82ydczid	24	18	fund	fund	NN
cord-253295-82ydczid	24	19	of	of	IN
cord-253295-82ydczid	24	20	knowledge	knowledge	NN
cord-253295-82ydczid	24	21	,	,	,
cord-253295-82ydczid	24	22	experience	experience	NN
cord-253295-82ydczid	24	23	,	,	,
cord-253295-82ydczid	24	24	alertness	alertness	NN
cord-253295-82ydczid	24	25	)	)	-RRB-
cord-253295-82ydczid	24	26	,	,	,
cord-253295-82ydczid	24	27	the	the	DT
cord-253295-82ydczid	24	28	prevalence	prevalence	NN
cord-253295-82ydczid	24	29	of	of	IN
cord-253295-82ydczid	24	30	the	the	DT
cord-253295-82ydczid	24	31	disease	disease	NN
cord-253295-82ydczid	24	32	in	in	IN
cord-253295-82ydczid	24	33	question	question	NN
cord-253295-82ydczid	24	34	in	in	IN
cord-253295-82ydczid	24	35	the	the	DT
cord-253295-82ydczid	24	36	particular	particular	JJ
cord-253295-82ydczid	24	37	patient	patient	NN
cord-253295-82ydczid	24	38	(	(	-LRB-
cord-253295-82ydczid	24	39	age	age	NN
cord-253295-82ydczid	24	40	,	,	,
cord-253295-82ydczid	24	41	race	race	NN
cord-253295-82ydczid	24	42	,	,	,
cord-253295-82ydczid	24	43	sex	sex	NN
cord-253295-82ydczid	24	44	,	,	,
cord-253295-82ydczid	24	45	site	site	NN
cord-253295-82ydczid	24	46	)	)	-RRB-
cord-253295-82ydczid	24	47	,	,	,
cord-253295-82ydczid	24	48	and	and	CC
cord-253295-82ydczid	24	49	the	the	DT
cord-253295-82ydczid	24	50	sensitivity/	sensitivity/	JJ
cord-253295-82ydczid	24	51	specificity	specificity	NN
cord-253295-82ydczid	24	52	of	of	IN
cord-253295-82ydczid	24	53	the	the	DT
cord-253295-82ydczid	24	54	screening	screening	NN
cord-253295-82ydczid	24	55	tests	test	NNS
cord-253295-82ydczid	24	56	used	use	VBN
cord-253295-82ydczid	24	57	(	(	-LRB-
cord-253295-82ydczid	24	58	physical	physical	JJ
cord-253295-82ydczid	24	59	exam	exam	NN
cord-253295-82ydczid	24	60	,	,	,
cord-253295-82ydczid	24	61	vital	vital	JJ
cord-253295-82ydczid	24	62	signs	sign	NNS
cord-253295-82ydczid	24	63	,	,	,
cord-253295-82ydczid	24	64	blood	blood	NN
cord-253295-82ydczid	24	65	solutes	solute	NNS
cord-253295-82ydczid	24	66	,	,	,
cord-253295-82ydczid	24	67	tissue	tissue	NN
cord-253295-82ydczid	24	68	stains	stain	NNS
cord-253295-82ydczid	24	69	,	,	,
cord-253295-82ydczid	24	70	genetic	genetic	JJ
cord-253295-82ydczid	24	71	assays	assay	NNS
cord-253295-82ydczid	24	72	)	)	-RRB-
cord-253295-82ydczid	24	73	.	.	.
cord-253295-82ydczid	25	1	The	the	DT
cord-253295-82ydczid	25	2	pathologic	pathologic	JJ
cord-253295-82ydczid	25	3	diagnosis	diagnosis	NN
cord-253295-82ydczid	25	4	represents	represent	VBZ
cord-253295-82ydczid	25	5	the	the	DT
cord-253295-82ydczid	25	6	best	good	JJS
cord-253295-82ydczid	25	7	estimate	estimate	NN
cord-253295-82ydczid	25	8	currently	currently	RB
cord-253295-82ydczid	25	9	possible	possible	JJ
cord-253295-82ydczid	25	10	of	of	IN
cord-253295-82ydczid	25	11	the	the	DT
cord-253295-82ydczid	25	12	disease	disease	NN
cord-253295-82ydczid	25	13	entity	entity	NN
cord-253295-82ydczid	25	14	affecting	affect	VBG
cord-253295-82ydczid	25	15	the	the	DT
cord-253295-82ydczid	25	16	patient	patient	NN
cord-253295-82ydczid	25	17	,	,	,
cord-253295-82ydczid	25	18	and	and	CC
cord-253295-82ydczid	25	19	is	be	VBZ
cord-253295-82ydczid	25	20	the	the	DT
cord-253295-82ydczid	25	21	basis	basis	NN
cord-253295-82ydczid	25	22	for	for	IN
cord-253295-82ydczid	25	23	downstream	downstream	JJ
cord-253295-82ydczid	25	24	follow	follow	NN
cord-253295-82ydczid	25	25	-	-	HYPH
cord-253295-82ydczid	25	26	up	up	NN
cord-253295-82ydczid	25	27	and	and	CC
cord-253295-82ydczid	25	28	treatment	treatment	NN
cord-253295-82ydczid	25	29	decisions	decision	NNS
cord-253295-82ydczid	25	30	.	.	.
cord-253295-82ydczid	26	1	The	the	DT
cord-253295-82ydczid	26	2	diagnosis	diagnosis	NN
cord-253295-82ydczid	26	3	implies	imply	VBZ
cord-253295-82ydczid	26	4	a	a	DT
cord-253295-82ydczid	26	5	natural	natural	JJ
cord-253295-82ydczid	26	6	history	history	NN
cord-253295-82ydczid	26	7	(	(	-LRB-
cord-253295-82ydczid	26	8	course	course	NN
cord-253295-82ydczid	26	9	of	of	IN
cord-253295-82ydczid	26	10	disease	disease	NN
cord-253295-82ydczid	26	11	,	,	,
cord-253295-82ydczid	26	12	including	include	VBG
cord-253295-82ydczid	26	13	chronicity	chronicity	NN
cord-253295-82ydczid	26	14	,	,	,
cord-253295-82ydczid	26	15	functional	functional	JJ
cord-253295-82ydczid	26	16	impairment	impairment	NN
cord-253295-82ydczid	26	17	,	,	,
cord-253295-82ydczid	26	18	and	and	CC
cord-253295-82ydczid	26	19	survival	survival	NN
cord-253295-82ydczid	26	20	)	)	-RRB-
cord-253295-82ydczid	26	21	that	that	IN
cord-253295-82ydczid	26	22	most	most	JJS
cord-253295-82ydczid	26	23	patients	patient	NNS
cord-253295-82ydczid	26	24	with	with	IN
cord-253295-82ydczid	26	25	this	this	DT
cord-253295-82ydczid	26	26	disease	disease	NN
cord-253295-82ydczid	26	27	are	be	VBP
cord-253295-82ydczid	26	28	expected	expect	VBN
cord-253295-82ydczid	26	29	to	to	TO
cord-253295-82ydczid	26	30	follow	follow	VB
cord-253295-82ydczid	26	31	.	.	.
cord-253295-82ydczid	27	1	Be	be	VB
cord-253295-82ydczid	27	2	aware	aware	JJ
cord-253295-82ydczid	27	3	that	that	IN
cord-253295-82ydczid	27	4	not	not	RB
cord-253295-82ydczid	27	5	all	all	DT
cord-253295-82ydczid	27	6	patients	patient	NNS
cord-253295-82ydczid	27	7	with	with	IN
cord-253295-82ydczid	27	8	a	a	DT
cord-253295-82ydczid	27	9	given	give	VBN
cord-253295-82ydczid	27	10	disease	disease	NN
cord-253295-82ydczid	27	11	will	will	MD
cord-253295-82ydczid	27	12	naturally	naturally	RB
cord-253295-82ydczid	27	13	follow	follow	VB
cord-253295-82ydczid	27	14	the	the	DT
cord-253295-82ydczid	27	15	same	same	JJ
cord-253295-82ydczid	27	16	disease	disease	NN
cord-253295-82ydczid	27	17	course	course	NN
cord-253295-82ydczid	27	18	,	,	,
cord-253295-82ydczid	27	19	so	so	CC
cord-253295-82ydczid	27	20	differences	difference	NNS
cord-253295-82ydczid	27	21	in	in	IN
cord-253295-82ydczid	27	22	patient	patient	JJ
cord-253295-82ydczid	27	23	outcome	outcome	NN
cord-253295-82ydczid	27	24	do	do	VBP
cord-253295-82ydczid	27	25	not	not	RB
cord-253295-82ydczid	27	26	necessarily	necessarily	RB
cord-253295-82ydczid	27	27	correspond	correspond	VB
cord-253295-82ydczid	27	28	to	to	IN
cord-253295-82ydczid	27	29	incorrect	incorrect	JJ
cord-253295-82ydczid	27	30	diagnosis	diagnosis	NN
cord-253295-82ydczid	27	31	.	.	.
cord-253295-82ydczid	28	1	Variables	variable	NNS
cord-253295-82ydczid	28	2	that	that	WDT
cord-253295-82ydczid	28	3	independently	independently	RB
cord-253295-82ydczid	28	4	correlate	correlate	VBP
cord-253295-82ydczid	28	5	with	with	IN
cord-253295-82ydczid	28	6	clinical	clinical	JJ
cord-253295-82ydczid	28	7	outcome	outcome	NN
cord-253295-82ydczid	28	8	differences	difference	NNS
cord-253295-82ydczid	28	9	are	be	VBP
cord-253295-82ydczid	28	10	called	call	VBN
cord-253295-82ydczid	28	11	independent	independent	JJ
cord-253295-82ydczid	28	12	prognostic	prognostic	JJ
cord-253295-82ydczid	28	13	variables	variable	NNS
cord-253295-82ydczid	28	14	,	,	,
cord-253295-82ydczid	28	15	and	and	CC
cord-253295-82ydczid	28	16	are	be	VBP
cord-253295-82ydczid	28	17	routinely	routinely	RB
cord-253295-82ydczid	28	18	assessed	assess	VBN
cord-253295-82ydczid	28	19	in	in	IN
cord-253295-82ydczid	28	20	an	an	DT
cord-253295-82ydczid	28	21	effort	effort	NN
cord-253295-82ydczid	28	22	to	to	TO
cord-253295-82ydczid	28	23	predict	predict	VB
cord-253295-82ydczid	28	24	the	the	DT
cord-253295-82ydczid	28	25	natural	natural	JJ
cord-253295-82ydczid	28	26	history	history	NN
cord-253295-82ydczid	28	27	of	of	IN
cord-253295-82ydczid	28	28	the	the	DT
cord-253295-82ydczid	28	29	disease	disease	NN
cord-253295-82ydczid	28	30	in	in	IN
cord-253295-82ydczid	28	31	the	the	DT
cord-253295-82ydczid	28	32	patient	patient	NN
cord-253295-82ydczid	28	33	.	.	.
cord-253295-82ydczid	29	1	It	-PRON-	PRP
cord-253295-82ydczid	29	2	is	be	VBZ
cord-253295-82ydczid	29	3	also	also	RB
cord-253295-82ydczid	29	4	important	important	JJ
cord-253295-82ydczid	29	5	to	to	TO
cord-253295-82ydczid	29	6	note	note	VB
cord-253295-82ydczid	29	7	that	that	IN
cord-253295-82ydczid	29	8	medical	medical	JJ
cord-253295-82ydczid	29	9	therapies	therapy	NNS
cord-253295-82ydczid	29	10	for	for	IN
cord-253295-82ydczid	29	11	specific	specific	JJ
cord-253295-82ydczid	29	12	diseases	disease	NNS
cord-253295-82ydczid	29	13	do	do	VBP
cord-253295-82ydczid	29	14	not	not	RB
cord-253295-82ydczid	29	15	always	always	RB
cord-253295-82ydczid	29	16	work	work	VB
cord-253295-82ydczid	29	17	.	.	.
cord-253295-82ydczid	30	1	Variables	variable	NNS
cord-253295-82ydczid	30	2	that	that	WDT
cord-253295-82ydczid	30	3	independently	independently	RB
cord-253295-82ydczid	30	4	correlate	correlate	VBP
cord-253295-82ydczid	30	5	with	with	IN
cord-253295-82ydczid	30	6	(	(	-LRB-
cord-253295-82ydczid	30	7	predict	predict	VB
cord-253295-82ydczid	30	8	)	)	-RRB-
cord-253295-82ydczid	30	9	responses	response	NNS
cord-253295-82ydczid	30	10	to	to	IN
cord-253295-82ydczid	30	11	therapy	therapy	NN
cord-253295-82ydczid	30	12	are	be	VBP
cord-253295-82ydczid	30	13	called	call	VBN
cord-253295-82ydczid	30	14	independent	independent	JJ
cord-253295-82ydczid	30	15	predictive	predictive	JJ
cord-253295-82ydczid	30	16	variables	variable	NNS
cord-253295-82ydczid	30	17	.	.	.
cord-253295-82ydczid	31	1	Diagnosis	diagnosis	NN
cord-253295-82ydczid	31	2	of	of	IN
cord-253295-82ydczid	31	3	a	a	DT
cord-253295-82ydczid	31	4	disease	disease	NN
cord-253295-82ydczid	31	5	and	and	CC
cord-253295-82ydczid	31	6	development	development	NN
cord-253295-82ydczid	31	7	of	of	IN
cord-253295-82ydczid	31	8	an	an	DT
cord-253295-82ydczid	31	9	effective	effective	JJ
cord-253295-82ydczid	31	10	therapy	therapy	NN
cord-253295-82ydczid	31	11	for	for	IN
cord-253295-82ydczid	31	12	that	that	DT
cord-253295-82ydczid	31	13	disease	disease	NN
cord-253295-82ydczid	31	14	do	do	VBP
cord-253295-82ydczid	31	15	not	not	RB
cord-253295-82ydczid	31	16	require	require	VB
cord-253295-82ydczid	31	17	knowledge	knowledge	NN
cord-253295-82ydczid	31	18	of	of	IN
cord-253295-82ydczid	31	19	the	the	DT
cord-253295-82ydczid	31	20	underlying	underlie	VBG
cord-253295-82ydczid	31	21	etiology	etiology	NN
cord-253295-82ydczid	31	22	or	or	CC
cord-253295-82ydczid	31	23	pathogenesis	pathogenesis	NN
cord-253295-82ydczid	31	24	.	.	.
cord-253295-82ydczid	32	1	For	for	IN
cord-253295-82ydczid	32	2	example	example	NN
cord-253295-82ydczid	32	3	,	,	,
cord-253295-82ydczid	32	4	granulomatous	granulomatous	JJ
cord-253295-82ydczid	32	5	polyangiitis	polyangiitis	NNP
cord-253295-82ydczid	32	6	(	(	-LRB-
cord-253295-82ydczid	32	7	née	née	VBN
cord-253295-82ydczid	32	8	Wegener	Wegener	NNP
cord-253295-82ydczid	32	9	's	's	POS
cord-253295-82ydczid	32	10	granulomatosis	granulomatosis	NN
cord-253295-82ydczid	32	11	)	)	-RRB-
cord-253295-82ydczid	32	12	was	be	VBD
cord-253295-82ydczid	32	13	understood	understand	VBN
cord-253295-82ydczid	32	14	by	by	IN
cord-253295-82ydczid	32	15	morphology	morphology	NN
cord-253295-82ydczid	32	16	and	and	CC
cord-253295-82ydczid	32	17	outcomes	outcome	NNS
cord-253295-82ydczid	32	18	to	to	TO
cord-253295-82ydczid	32	19	be	be	VB
cord-253295-82ydczid	32	20	a	a	DT
cord-253295-82ydczid	32	21	lethal	lethal	JJ
cord-253295-82ydczid	32	22	disease	disease	NN
cord-253295-82ydczid	32	23	without	without	IN
cord-253295-82ydczid	32	24	treatment	treatment	NN
cord-253295-82ydczid	32	25	,	,	,
cord-253295-82ydczid	32	26	yet	yet	CC
cord-253295-82ydczid	32	27	responsive	responsive	JJ
cord-253295-82ydczid	32	28	to	to	IN
cord-253295-82ydczid	32	29	cyclophosphamide	cyclophosphamide	NN
cord-253295-82ydczid	32	30	and	and	CC
cord-253295-82ydczid	32	31	corticosteroids	corticosteroid	NNS
cord-253295-82ydczid	32	32	,	,	,
cord-253295-82ydczid	32	33	before	before	IN
cord-253295-82ydczid	32	34	it	-PRON-	PRP
cord-253295-82ydczid	32	35	was	be	VBD
cord-253295-82ydczid	32	36	found	find	VBN
cord-253295-82ydczid	32	37	to	to	TO
cord-253295-82ydczid	32	38	be	be	VB
cord-253295-82ydczid	32	39	an	an	DT
cord-253295-82ydczid	32	40	autoimmune	autoimmune	JJ
cord-253295-82ydczid	32	41	disease	disease	NN
cord-253295-82ydczid	32	42	targeting	target	VBG
cord-253295-82ydczid	32	43	neutrophil	neutrophil	NN
cord-253295-82ydczid	32	44	cytoplasmic	cytoplasmic	JJ
cord-253295-82ydczid	32	45	protein	protein	NN
cord-253295-82ydczid	32	46	PR3	PR3	NNP
cord-253295-82ydczid	32	47	(	(	-LRB-
cord-253295-82ydczid	32	48	Fig	Fig	NNP
cord-253295-82ydczid	32	49	.	.	.
cord-253295-82ydczid	32	50	11.1	11.1	CD
cord-253295-82ydczid	32	51	)	)	-RRB-
cord-253295-82ydczid	32	52	.	.	.
cord-253295-82ydczid	33	1	However	however	RB
cord-253295-82ydczid	33	2	,	,	,
cord-253295-82ydczid	33	3	understanding	understand	VBG
cord-253295-82ydczid	33	4	the	the	DT
cord-253295-82ydczid	33	5	molecular	molecular	JJ
cord-253295-82ydczid	33	6	and	and	CC
cord-253295-82ydczid	33	7	cellular	cellular	JJ
cord-253295-82ydczid	33	8	pathogenesis	pathogenesis	NN
cord-253295-82ydczid	33	9	of	of	IN
cord-253295-82ydczid	33	10	a	a	DT
cord-253295-82ydczid	33	11	disease	disease	NN
cord-253295-82ydczid	33	12	allows	allow	VBZ
cord-253295-82ydczid	33	13	development	development	NN
cord-253295-82ydczid	33	14	of	of	IN
cord-253295-82ydczid	33	15	screening	screening	NN
cord-253295-82ydczid	33	16	methods	method	NNS
cord-253295-82ydczid	33	17	to	to	TO
cord-253295-82ydczid	33	18	determine	determine	VB
cord-253295-82ydczid	33	19	risk	risk	NN
cord-253295-82ydczid	33	20	for	for	IN
cord-253295-82ydczid	33	21	clinically	clinically	RB
cord-253295-82ydczid	33	22	unaffected	unaffected	JJ
cord-253295-82ydczid	33	23	individuals	individual	NNS
cord-253295-82ydczid	33	24	,	,	,
cord-253295-82ydczid	33	25	as	as	RB
cord-253295-82ydczid	33	26	well	well	RB
cord-253295-82ydczid	33	27	as	as	IN
cord-253295-82ydczid	33	28	mechanistic	mechanistic	JJ
cord-253295-82ydczid	33	29	approaches	approach	NNS
cord-253295-82ydczid	33	30	to	to	IN
cord-253295-82ydczid	33	31	specific	specific	JJ
cord-253295-82ydczid	33	32	therapy	therapy	NN
cord-253295-82ydczid	33	33	.	.	.
cord-253295-82ydczid	34	1	The	the	DT
cord-253295-82ydczid	34	2	Pathologist	Pathologist	NNP
cord-253295-82ydczid	34	3	is	be	VBZ
cord-253295-82ydczid	34	4	that	that	DT
cord-253295-82ydczid	34	5	physician	physician	NN
cord-253295-82ydczid	34	6	or	or	CC
cord-253295-82ydczid	34	7	clinical	clinical	JJ
cord-253295-82ydczid	34	8	scientist	scientist	NN
cord-253295-82ydczid	34	9	who	who	WP
cord-253295-82ydczid	34	10	specializes	specialize	VBZ
cord-253295-82ydczid	34	11	in	in	IN
cord-253295-82ydczid	34	12	the	the	DT
cord-253295-82ydczid	34	13	art	art	NN
cord-253295-82ydczid	34	14	and	and	CC
cord-253295-82ydczid	34	15	science	science	NN
cord-253295-82ydczid	34	16	of	of	IN
cord-253295-82ydczid	34	17	medical	medical	JJ
cord-253295-82ydczid	34	18	risk	risk	NN
cord-253295-82ydczid	34	19	estimation	estimation	NN
cord-253295-82ydczid	34	20	and	and	CC
cord-253295-82ydczid	34	21	disease	disease	NN
cord-253295-82ydczid	34	22	diagnosis	diagnosis	NN
cord-253295-82ydczid	34	23	,	,	,
cord-253295-82ydczid	34	24	using	use	VBG
cord-253295-82ydczid	34	25	observations	observation	NNS
cord-253295-82ydczid	34	26	at	at	IN
cord-253295-82ydczid	34	27	the	the	DT
cord-253295-82ydczid	34	28	clinical	clinical	JJ
cord-253295-82ydczid	34	29	,	,	,
cord-253295-82ydczid	34	30	gross	gross	JJ
cord-253295-82ydczid	34	31	,	,	,
cord-253295-82ydczid	34	32	body	body	NN
cord-253295-82ydczid	34	33	fluid	fluid	NN
cord-253295-82ydczid	34	34	,	,	,
cord-253295-82ydczid	34	35	light	light	JJ
cord-253295-82ydczid	34	36	microscopic	microscopic	JJ
cord-253295-82ydczid	34	37	,	,	,
cord-253295-82ydczid	34	38	immunophenotypic	immunophenotypic	NNP
cord-253295-82ydczid	34	39	,	,	,
cord-253295-82ydczid	34	40	ultrastructural	ultrastructural	JJ
cord-253295-82ydczid	34	41	,	,	,
cord-253295-82ydczid	34	42	cytogenetic	cytogenetic	JJ
cord-253295-82ydczid	34	43	,	,	,
cord-253295-82ydczid	34	44	and	and	CC
cord-253295-82ydczid	34	45	molecular	molecular	JJ
cord-253295-82ydczid	34	46	levels	level	NNS
cord-253295-82ydczid	34	47	.	.	.
cord-253295-82ydczid	35	1	Clearly	clearly	RB
cord-253295-82ydczid	35	2	,	,	,
cord-253295-82ydczid	35	3	the	the	DT
cord-253295-82ydczid	35	4	pathologist	pathologist	NN
cord-253295-82ydczid	35	5	has	have	VBZ
cord-253295-82ydczid	35	6	a	a	DT
cord-253295-82ydczid	35	7	duty	duty	NN
cord-253295-82ydczid	35	8	to	to	TO
cord-253295-82ydczid	35	9	master	master	VB
cord-253295-82ydczid	35	10	any	any	DT
cord-253295-82ydczid	35	11	new	new	JJ
cord-253295-82ydczid	35	12	concepts	concept	NNS
cord-253295-82ydczid	35	13	,	,	,
cord-253295-82ydczid	35	14	factual	factual	JJ
cord-253295-82ydczid	35	15	knowledge	knowledge	NN
cord-253295-82ydczid	35	16	,	,	,
cord-253295-82ydczid	35	17	and	and	CC
cord-253295-82ydczid	35	18	technology	technology	NN
cord-253295-82ydczid	35	19	that	that	WDT
cord-253295-82ydczid	35	20	can	can	MD
cord-253295-82ydczid	35	21	aid	aid	VB
cord-253295-82ydczid	35	22	in	in	IN
cord-253295-82ydczid	35	23	the	the	DT
cord-253295-82ydczid	35	24	estimation	estimation	NN
cord-253295-82ydczid	35	25	of	of	IN
cord-253295-82ydczid	35	26	risk	risk	NN
cord-253295-82ydczid	35	27	for	for	IN
cord-253295-82ydczid	35	28	unaffected	unaffected	JJ
cord-253295-82ydczid	35	29	individuals	individual	NNS
cord-253295-82ydczid	35	30	,	,	,
cord-253295-82ydczid	35	31	the	the	DT
cord-253295-82ydczid	35	32	statement	statement	NN
cord-253295-82ydczid	35	33	of	of	IN
cord-253295-82ydczid	35	34	accurate	accurate	JJ
cord-253295-82ydczid	35	35	and	and	CC
cord-253295-82ydczid	35	36	timely	timely	JJ
cord-253295-82ydczid	35	37	diagnosis	diagnosis	NN
cord-253295-82ydczid	35	38	,	,	,
cord-253295-82ydczid	35	39	accurate	accurate	JJ
cord-253295-82ydczid	35	40	prognosis	prognosis	NN
cord-253295-82ydczid	35	41	,	,	,
cord-253295-82ydczid	35	42	and	and	CC
cord-253295-82ydczid	35	43	accurate	accurate	JJ
cord-253295-82ydczid	35	44	prediction	prediction	NN
cord-253295-82ydczid	35	45	of	of	IN
cord-253295-82ydczid	35	46	response	response	NN
cord-253295-82ydczid	35	47	to	to	IN
cord-253295-82ydczid	35	48	therapy	therapy	NN
cord-253295-82ydczid	35	49	for	for	IN
cord-253295-82ydczid	35	50	affected	affect	VBN
cord-253295-82ydczid	35	51	individuals	individual	NNS
cord-253295-82ydczid	35	52	.	.	.
cord-253295-82ydczid	36	1	The	the	DT
cord-253295-82ydczid	36	2	ability	ability	NN
cord-253295-82ydczid	36	3	of	of	IN
cord-253295-82ydczid	36	4	H.	h.	NN
cord-253295-82ydczid	36	5	sapiens	sapiens	NNP
cord-253295-82ydczid	36	6	to	to	TO
cord-253295-82ydczid	36	7	adapt	adapt	VB
cord-253295-82ydczid	36	8	and	and	CC
cord-253295-82ydczid	36	9	thrive	thrive	VB
cord-253295-82ydczid	36	10	has	have	VBZ
cord-253295-82ydczid	36	11	been	be	VBN
cord-253295-82ydczid	36	12	due	due	JJ
cord-253295-82ydczid	36	13	in	in	IN
cord-253295-82ydczid	36	14	part	part	NN
cord-253295-82ydczid	36	15	to	to	IN
cord-253295-82ydczid	36	16	the	the	DT
cord-253295-82ydczid	36	17	ability	ability	NN
cord-253295-82ydczid	36	18	of	of	IN
cord-253295-82ydczid	36	19	humans	human	NNS
cord-253295-82ydczid	36	20	to	to	TO
cord-253295-82ydczid	36	21	remember	remember	VB
cord-253295-82ydczid	36	22	the	the	DT
cord-253295-82ydczid	36	23	past	past	NN
cord-253295-82ydczid	36	24	,	,	,
cord-253295-82ydczid	36	25	respect	respect	NN
cord-253295-82ydczid	36	26	tradition	tradition	NN
cord-253295-82ydczid	36	27	,	,	,
cord-253295-82ydczid	36	28	recognize	recognize	VB
cord-253295-82ydczid	36	29	the	the	DT
cord-253295-82ydczid	36	30	value	value	NN
cord-253295-82ydczid	36	31	of	of	IN
cord-253295-82ydczid	36	32	new	new	JJ
cord-253295-82ydczid	36	33	observations	observation	NNS
cord-253295-82ydczid	36	34	,	,	,
cord-253295-82ydczid	36	35	develop	develop	VB
cord-253295-82ydczid	36	36	tools	tool	NNS
cord-253295-82ydczid	36	37	/	/	SYM
cord-253295-82ydczid	36	38	symbols	symbol	NNS
cord-253295-82ydczid	36	39	,	,	,
cord-253295-82ydczid	36	40	manipulate	manipulate	VB
cord-253295-82ydczid	36	41	the	the	DT
cord-253295-82ydczid	36	42	environment	environment	NN
cord-253295-82ydczid	36	43	,	,	,
cord-253295-82ydczid	36	44	anticipate	anticipate	VB
cord-253295-82ydczid	36	45	the	the	DT
cord-253295-82ydczid	36	46	future	future	NN
cord-253295-82ydczid	36	47	,	,	,
cord-253295-82ydczid	36	48	and	and	CC
cord-253295-82ydczid	36	49	role	role	NN
cord-253295-82ydczid	36	50	-	-	:
cord-253295-82ydczid	36	51	specialize	specialize	VBP
cord-253295-82ydczid	36	52	in	in	IN
cord-253295-82ydczid	36	53	a	a	DT
cord-253295-82ydczid	36	54	social	social	JJ
cord-253295-82ydczid	36	55	structure	structure	NN
cord-253295-82ydczid	36	56	.	.	.
cord-253295-82ydczid	37	1	The	the	DT
cord-253295-82ydczid	37	2	history	history	NN
cord-253295-82ydczid	37	3	of	of	IN
cord-253295-82ydczid	37	4	human	human	JJ
cord-253295-82ydczid	37	5	understanding	understanding	NN
cord-253295-82ydczid	37	6	of	of	IN
cord-253295-82ydczid	37	7	diseases	disease	NNS
cord-253295-82ydczid	37	8	has	have	VBZ
cord-253295-82ydczid	37	9	progressed	progress	VBN
cord-253295-82ydczid	37	10	at	at	IN
cord-253295-82ydczid	37	11	variable	variable	JJ
cord-253295-82ydczid	37	12	rates	rate	NNS
cord-253295-82ydczid	37	13	,	,	,
cord-253295-82ydczid	37	14	depending	depend	VBG
cord-253295-82ydczid	37	15	on	on	IN
cord-253295-82ydczid	37	16	the	the	DT
cord-253295-82ydczid	37	17	good	good	JJ
cord-253295-82ydczid	37	18	and	and	CC
cord-253295-82ydczid	37	19	bad	bad	JJ
cord-253295-82ydczid	37	20	aspects	aspect	NNS
cord-253295-82ydczid	37	21	of	of	IN
cord-253295-82ydczid	37	22	these	these	DT
cord-253295-82ydczid	37	23	human	human	JJ
cord-253295-82ydczid	37	24	characteristics	characteristic	NNS
cord-253295-82ydczid	37	25	.	.	.
cord-253295-82ydczid	38	1	Our	-PRON-	PRP$
cord-253295-82ydczid	38	2	understanding	understanding	NN
cord-253295-82ydczid	38	3	of	of	IN
cord-253295-82ydczid	38	4	ancient	ancient	JJ
cord-253295-82ydczid	38	5	attitudes	attitude	NNS
cord-253295-82ydczid	38	6	toward	toward	IN
cord-253295-82ydczid	38	7	diseases	disease	NNS
cord-253295-82ydczid	38	8	is	be	VBZ
cord-253295-82ydczid	38	9	limited	limit	VBN
cord-253295-82ydczid	38	10	by	by	IN
cord-253295-82ydczid	38	11	the	the	DT
cord-253295-82ydczid	38	12	historical	historical	JJ
cord-253295-82ydczid	38	13	written	write	VBN
cord-253295-82ydczid	38	14	record	record	NN
cord-253295-82ydczid	38	15	.	.	.
cord-253295-82ydczid	39	1	Thus	thus	RB
cord-253295-82ydczid	39	2	,	,	,
cord-253295-82ydczid	39	3	the	the	DT
cord-253295-82ydczid	39	4	start	start	NN
cord-253295-82ydczid	39	5	point	point	NN
cord-253295-82ydczid	39	6	for	for	IN
cord-253295-82ydczid	39	7	written	write	VBN
cord-253295-82ydczid	39	8	medical	medical	JJ
cord-253295-82ydczid	39	9	history	history	NN
cord-253295-82ydczid	39	10	corresponds	correspond	VBZ
cord-253295-82ydczid	39	11	to	to	IN
cord-253295-82ydczid	39	12	around	around	IN
cord-253295-82ydczid	39	13	1700	1700	CD
cord-253295-82ydczid	39	14	BCE	BCE	NNP
cord-253295-82ydczid	39	15	for	for	IN
cord-253295-82ydczid	39	16	Mesopotamian	mesopotamian	JJ
cord-253295-82ydczid	39	17	rules	rule	NNS
cord-253295-82ydczid	39	18	in	in	IN
cord-253295-82ydczid	39	19	the	the	DT
cord-253295-82ydczid	39	20	code	code	NN
cord-253295-82ydczid	39	21	of	of	IN
cord-253295-82ydczid	39	22	Hammurabi	Hammurabi	NNP
cord-253295-82ydczid	39	23	,	,	,
cord-253295-82ydczid	39	24	and	and	CC
cord-253295-82ydczid	39	25	around	around	IN
cord-253295-82ydczid	39	26	1550	1550	CD
cord-253295-82ydczid	39	27	BCE	BCE	NNP
cord-253295-82ydczid	39	28	for	for	IN
cord-253295-82ydczid	39	29	the	the	DT
cord-253295-82ydczid	39	30	analogous	analogous	JJ
cord-253295-82ydczid	39	31	Egyptian	egyptian	JJ
cord-253295-82ydczid	39	32	rules	rule	NNS
cord-253295-82ydczid	39	33	in	in	IN
cord-253295-82ydczid	39	34	the	the	DT
cord-253295-82ydczid	39	35	Ebers	Ebers	NNP
cord-253295-82ydczid	39	36	papyrus	papyrus	NN
cord-253295-82ydczid	39	37	.	.	.
cord-253295-82ydczid	40	1	By	by	IN
cord-253295-82ydczid	40	2	definition	definition	NN
cord-253295-82ydczid	40	3	,	,	,
cord-253295-82ydczid	40	4	these	these	DT
cord-253295-82ydczid	40	5	philosophers	philosopher	NNS
cord-253295-82ydczid	40	6	,	,	,
cord-253295-82ydczid	40	7	theologians	theologian	NNS
cord-253295-82ydczid	40	8	,	,	,
cord-253295-82ydczid	40	9	and	and	CC
cord-253295-82ydczid	40	10	physicians	physician	NNS
cord-253295-82ydczid	40	11	had	have	VBD
cord-253295-82ydczid	40	12	access	access	NN
cord-253295-82ydczid	40	13	and	and	CC
cord-253295-82ydczid	40	14	assets	asset	NNS
cord-253295-82ydczid	40	15	to	to	TO
cord-253295-82ydczid	40	16	allow	allow	VB
cord-253295-82ydczid	40	17	a	a	DT
cord-253295-82ydczid	40	18	written	write	VBN
cord-253295-82ydczid	40	19	record	record	NN
cord-253295-82ydczid	40	20	,	,	,
cord-253295-82ydczid	40	21	and	and	CC
cord-253295-82ydczid	40	22	materials	material	NNS
cord-253295-82ydczid	40	23	and	and	CC
cord-253295-82ydczid	40	24	storage	storage	NN
cord-253295-82ydczid	40	25	sufficient	sufficient	JJ
cord-253295-82ydczid	40	26	for	for	IN
cord-253295-82ydczid	40	27	the	the	DT
cord-253295-82ydczid	40	28	written	write	VBN
cord-253295-82ydczid	40	29	records	record	NNS
cord-253295-82ydczid	40	30	to	to	TO
cord-253295-82ydczid	40	31	survive	survive	VB
cord-253295-82ydczid	40	32	.	.	.
cord-253295-82ydczid	41	1	The	the	DT
cord-253295-82ydczid	41	2	Mesopotamian	mesopotamian	JJ
cord-253295-82ydczid	41	3	records	record	NNS
cord-253295-82ydczid	41	4	indicate	indicate	VBP
cord-253295-82ydczid	41	5	a	a	DT
cord-253295-82ydczid	41	6	deity	deity	NN
cord-253295-82ydczid	41	7	-	-	HYPH
cord-253295-82ydczid	41	8	driven	drive	VBN
cord-253295-82ydczid	41	9	,	,	,
cord-253295-82ydczid	41	10	demon	demon	NN
cord-253295-82ydczid	41	11	-	-	HYPH
cord-253295-82ydczid	41	12	driven	drive	VBN
cord-253295-82ydczid	41	13	theory	theory	NN
cord-253295-82ydczid	41	14	and	and	CC
cord-253295-82ydczid	41	15	empirical	empirical	JJ
cord-253295-82ydczid	41	16	practice	practice	NN
cord-253295-82ydczid	41	17	by	by	IN
cord-253295-82ydczid	41	18	recognized	recognize	VBN
cord-253295-82ydczid	41	19	professional	professional	JJ
cord-253295-82ydczid	41	20	physicians	physician	NNS
cord-253295-82ydczid	41	21	.	.	.
cord-253295-82ydczid	42	1	In	in	IN
cord-253295-82ydczid	42	2	this	this	DT
cord-253295-82ydczid	42	3	context	context	NN
cord-253295-82ydczid	42	4	,	,	,
cord-253295-82ydczid	42	5	the	the	DT
cord-253295-82ydczid	42	6	prevailing	prevail	VBG
cord-253295-82ydczid	42	7	thought	thought	NN
cord-253295-82ydczid	42	8	was	be	VBD
cord-253295-82ydczid	42	9	that	that	IN
cord-253295-82ydczid	42	10	"	"	``
cord-253295-82ydczid	42	11	Disease	Disease	NNP
cord-253295-82ydczid	42	12	was	be	VBD
cord-253295-82ydczid	42	13	caused	cause	VBN
cord-253295-82ydczid	42	14	by	by	IN
cord-253295-82ydczid	42	15	sprit	sprit	NN
cord-253295-82ydczid	42	16	invasion	invasion	NN
cord-253295-82ydczid	42	17	,	,	,
cord-253295-82ydczid	42	18	sorcery	sorcery	NN
cord-253295-82ydczid	42	19	,	,	,
cord-253295-82ydczid	42	20	malice	malice	NN
cord-253295-82ydczid	42	21	,	,	,
cord-253295-82ydczid	42	22	or	or	CC
cord-253295-82ydczid	42	23	the	the	DT
cord-253295-82ydczid	42	24	breaking	breaking	NN
cord-253295-82ydczid	42	25	of	of	IN
cord-253295-82ydczid	42	26	taboos	taboo	NNS
cord-253295-82ydczid	42	27	;	;	:
cord-253295-82ydczid	42	28	sickness	sickness	NN
cord-253295-82ydczid	42	29	was	be	VBD
cord-253295-82ydczid	42	30	both	both	DT
cord-253295-82ydczid	42	31	judgment	judgment	NN
cord-253295-82ydczid	42	32	and	and	CC
cord-253295-82ydczid	42	33	punishment	punishment	NN
cord-253295-82ydczid	42	34	.	.	.
cord-253295-82ydczid	42	35	.	.	.
cord-253295-82ydczid	42	36	.	.	.
cord-253295-82ydczid	43	1	"	"	''
cord-253295-82ydczid	44	1	The	the	DT
cord-253295-82ydczid	44	2	Greek	greek	JJ
cord-253295-82ydczid	44	3	medical	medical	JJ
cord-253295-82ydczid	44	4	community	community	NN
cord-253295-82ydczid	44	5	evolved	evolve	VBD
cord-253295-82ydczid	44	6	a	a	DT
cord-253295-82ydczid	44	7	theory	theory	NN
cord-253295-82ydczid	44	8	of	of	IN
cord-253295-82ydczid	44	9	disease	disease	NN
cord-253295-82ydczid	44	10	related	relate	VBN
cord-253295-82ydczid	44	11	to	to	IN
cord-253295-82ydczid	44	12	natural	natural	JJ
cord-253295-82ydczid	44	13	causes	cause	NNS
cord-253295-82ydczid	44	14	and	and	CC
cord-253295-82ydczid	44	15	effects	effect	NNS
cord-253295-82ydczid	44	16	,	,	,
cord-253295-82ydczid	44	17	with	with	IN
cord-253295-82ydczid	44	18	less	less	JJR
cord-253295-82ydczid	44	19	emphasis	emphasis	NN
cord-253295-82ydczid	44	20	on	on	IN
cord-253295-82ydczid	44	21	deity	deity	NN
cord-253295-82ydczid	44	22	-	-	HYPH
cord-253295-82ydczid	44	23	driven	drive	VBN
cord-253295-82ydczid	44	24	theory	theory	NN
cord-253295-82ydczid	44	25	.	.	.
cord-253295-82ydczid	45	1	The	the	DT
cord-253295-82ydczid	45	2	Hippocratic	Hippocratic	NNP
cord-253295-82ydczid	45	3	Corpus	Corpus	NNP
cord-253295-82ydczid	45	4	includes	include	VBZ
cord-253295-82ydczid	45	5	"	"	``
cord-253295-82ydczid	45	6	On	on	IN
cord-253295-82ydczid	45	7	the	the	DT
cord-253295-82ydczid	45	8	Sacred	Sacred	NNP
cord-253295-82ydczid	45	9	Disease	Disease	NNP
cord-253295-82ydczid	45	10	"	"	''
cord-253295-82ydczid	45	11	(	(	-LRB-
cord-253295-82ydczid	45	12	circa	circa	NN
cord-253295-82ydczid	45	13	400	400	CD
cord-253295-82ydczid	45	14	BCE	BCE	NNP
cord-253295-82ydczid	45	15	)	)	-RRB-
cord-253295-82ydczid	45	16	,	,	,
cord-253295-82ydczid	45	17	which	which	WDT
cord-253295-82ydczid	45	18	rejected	reject	VBD
cord-253295-82ydczid	45	19	a	a	DT
cord-253295-82ydczid	45	20	divine	divine	JJ
cord-253295-82ydczid	45	21	origin	origin	NN
cord-253295-82ydczid	45	22	for	for	IN
cord-253295-82ydczid	45	23	diseases	disease	NNS
cord-253295-82ydczid	45	24	,	,	,
cord-253295-82ydczid	45	25	and	and	CC
cord-253295-82ydczid	45	26	postulated	postulate	VBD
cord-253295-82ydczid	45	27	a	a	DT
cord-253295-82ydczid	45	28	natural	natural	JJ
cord-253295-82ydczid	45	29	rather	rather	RB
cord-253295-82ydczid	45	30	than	than	IN
cord-253295-82ydczid	45	31	supernatural	supernatural	JJ
cord-253295-82ydczid	45	32	basis	basis	NN
cord-253295-82ydczid	45	33	for	for	IN
cord-253295-82ydczid	45	34	disease	disease	NN
cord-253295-82ydczid	45	35	etiology	etiology	NN
cord-253295-82ydczid	45	36	(	(	-LRB-
cord-253295-82ydczid	45	37	"	"	''
cord-253295-82ydczid	45	38	.	.	.
cord-253295-82ydczid	45	39	.	.	.
cord-253295-82ydczid	45	40	.	.	.
cord-253295-82ydczid	46	1	nowise	nowise	RB
cord-253295-82ydczid	46	2	more	more	RBR
cord-253295-82ydczid	46	3	divine	divine	JJ
cord-253295-82ydczid	46	4	nor	nor	CC
cord-253295-82ydczid	46	5	more	more	RBR
cord-253295-82ydczid	46	6	sacred	sacred	JJ
cord-253295-82ydczid	46	7	than	than	IN
cord-253295-82ydczid	46	8	other	other	JJ
cord-253295-82ydczid	46	9	diseases	disease	NNS
cord-253295-82ydczid	46	10	,	,	,
cord-253295-82ydczid	46	11	but	but	CC
cord-253295-82ydczid	46	12	has	have	VBZ
cord-253295-82ydczid	46	13	a	a	DT
cord-253295-82ydczid	46	14	natural	natural	JJ
cord-253295-82ydczid	46	15	cause	cause	NN
cord-253295-82ydczid	46	16	.	.	.
cord-253295-82ydczid	46	17	.	.	.
cord-253295-82ydczid	46	18	.	.	.
cord-253295-82ydczid	47	1	like	like	IN
cord-253295-82ydczid	47	2	other	other	JJ
cord-253295-82ydczid	47	3	affections	affection	NNS
cord-253295-82ydczid	47	4	.	.	.
cord-253295-82ydczid	47	5	.	.	.
cord-253295-82ydczid	47	6	.	.	.
cord-253295-82ydczid	47	7	"	"	''
cord-253295-82ydczid	47	8	)	)	-RRB-
cord-253295-82ydczid	47	9	.	.	.
cord-253295-82ydczid	48	1	Aristotle	Aristotle	NNP
cord-253295-82ydczid	48	2	(	(	-LRB-
cord-253295-82ydczid	48	3	384À322	384à322	CD
cord-253295-82ydczid	48	4	BCE	BCE	NNP
cord-253295-82ydczid	48	5	)	)	-RRB-
cord-253295-82ydczid	48	6	wrote	write	VBD
cord-253295-82ydczid	48	7	broadly	broadly	RB
cord-253295-82ydczid	48	8	on	on	IN
cord-253295-82ydczid	48	9	topics	topic	NNS
cord-253295-82ydczid	48	10	including	include	VBG
cord-253295-82ydczid	48	11	logic	logic	NN
cord-253295-82ydczid	48	12	,	,	,
cord-253295-82ydczid	48	13	biology	biology	NN
cord-253295-82ydczid	48	14	,	,	,
cord-253295-82ydczid	48	15	physics	physics	NN
cord-253295-82ydczid	48	16	,	,	,
cord-253295-82ydczid	48	17	metaphysics	metaphysics	NN
cord-253295-82ydczid	48	18	,	,	,
cord-253295-82ydczid	48	19	and	and	CC
cord-253295-82ydczid	48	20	psychology	psychology	NN
cord-253295-82ydczid	48	21	.	.	.
cord-253295-82ydczid	49	1	To	to	IN
cord-253295-82ydczid	49	2	Aristotle	Aristotle	NNP
cord-253295-82ydczid	49	3	,	,	,
cord-253295-82ydczid	49	4	observations	observation	NNS
cord-253295-82ydczid	49	5	led	lead	VBD
cord-253295-82ydczid	49	6	to	to	IN
cord-253295-82ydczid	49	7	a	a	DT
cord-253295-82ydczid	49	8	description	description	NN
cord-253295-82ydczid	49	9	of	of	IN
cord-253295-82ydczid	49	10	causes	cause	NNS
cord-253295-82ydczid	49	11	,	,	,
cord-253295-82ydczid	49	12	or	or	CC
cord-253295-82ydczid	49	13	first	first	JJ
cord-253295-82ydczid	49	14	principles	principle	NNS
cord-253295-82ydczid	49	15	,	,	,
cord-253295-82ydczid	49	16	which	which	WDT
cord-253295-82ydczid	49	17	in	in	IN
cord-253295-82ydczid	49	18	turn	turn	NN
cord-253295-82ydczid	49	19	could	could	MD
cord-253295-82ydczid	49	20	be	be	VB
cord-253295-82ydczid	49	21	used	use	VBN
cord-253295-82ydczid	49	22	logically	logically	RB
cord-253295-82ydczid	49	23	in	in	IN
cord-253295-82ydczid	49	24	syllogisms	syllogism	NNS
cord-253295-82ydczid	49	25	to	to	TO
cord-253295-82ydczid	49	26	predict	predict	VB
cord-253295-82ydczid	49	27	future	future	JJ
cord-253295-82ydczid	49	28	observations	observation	NNS
cord-253295-82ydczid	49	29	.	.	.
cord-253295-82ydczid	50	1	We	-PRON-	PRP
cord-253295-82ydczid	50	2	would	would	MD
cord-253295-82ydczid	50	3	agree	agree	VB
cord-253295-82ydczid	50	4	with	with	IN
cord-253295-82ydczid	50	5	these	these	DT
cord-253295-82ydczid	50	6	basic	basic	JJ
cord-253295-82ydczid	50	7	notions	notion	NNS
cord-253295-82ydczid	50	8	of	of	IN
cord-253295-82ydczid	50	9	induction	induction	NN
cord-253295-82ydczid	50	10	and	and	CC
cord-253295-82ydczid	50	11	deduction	deduction	NN
cord-253295-82ydczid	50	12	.	.	.
cord-253295-82ydczid	51	1	However	however	RB
cord-253295-82ydczid	51	2	,	,	,
cord-253295-82ydczid	51	3	there	there	EX
cord-253295-82ydczid	51	4	was	be	VBD
cord-253295-82ydczid	51	5	a	a	DT
cord-253295-82ydczid	51	6	different	different	JJ
cord-253295-82ydczid	51	7	background	background	NN
cord-253295-82ydczid	51	8	philosophical	philosophical	JJ
cord-253295-82ydczid	51	9	construct	construct	NN
cord-253295-82ydczid	51	10	regarding	regard	VBG
cord-253295-82ydczid	51	11	the	the	DT
cord-253295-82ydczid	51	12	nature	nature	NN
cord-253295-82ydczid	51	13	of	of	IN
cord-253295-82ydczid	51	14	matter	matter	NN
cord-253295-82ydczid	51	15	and	and	CC
cord-253295-82ydczid	51	16	causality	causality	NN
cord-253295-82ydczid	51	17	(	(	-LRB-
cord-253295-82ydczid	51	18	four	four	CD
cord-253295-82ydczid	51	19	elements	element	NNS
cord-253295-82ydczid	51	20	,	,	,
cord-253295-82ydczid	51	21	four	four	CD
cord-253295-82ydczid	51	22	humors	humor	NNS
cord-253295-82ydczid	51	23	,	,	,
cord-253295-82ydczid	51	24	and	and	CC
cord-253295-82ydczid	51	25	four	four	CD
cord-253295-82ydczid	51	26	causes	cause	NNS
cord-253295-82ydczid	51	27	,	,	,
cord-253295-82ydczid	51	28	including	include	VBG
cord-253295-82ydczid	51	29	a	a	DT
cord-253295-82ydczid	51	30	final	final	JJ
cord-253295-82ydczid	51	31	or	or	CC
cord-253295-82ydczid	51	32	teleological	teleological	JJ
cord-253295-82ydczid	51	33	purpose	purpose	NN
cord-253295-82ydczid	51	34	)	)	-RRB-
cord-253295-82ydczid	51	35	.	.	.
cord-253295-82ydczid	52	1	We	-PRON-	PRP
cord-253295-82ydczid	52	2	would	would	MD
cord-253295-82ydczid	52	3	recognize	recognize	VB
cord-253295-82ydczid	52	4	Aristotle	Aristotle	NNP
cord-253295-82ydczid	52	5	's	's	POS
cord-253295-82ydczid	52	6	"	"	``
cord-253295-82ydczid	52	7	efficient	efficient	JJ
cord-253295-82ydczid	52	8	"	"	''
cord-253295-82ydczid	52	9	cause	cause	NN
cord-253295-82ydczid	52	10	of	of	IN
cord-253295-82ydczid	52	11	a	a	DT
cord-253295-82ydczid	52	12	disease	disease	NN
cord-253295-82ydczid	52	13	as	as	IN
cord-253295-82ydczid	52	14	its	-PRON-	PRP$
cord-253295-82ydczid	52	15	etiology	etiology	NN
cord-253295-82ydczid	52	16	.	.	.
cord-253295-82ydczid	53	1	Alexander	Alexander	NNP
cord-253295-82ydczid	53	2	the	the	DT
cord-253295-82ydczid	53	3	Great	Great	NNP
cord-253295-82ydczid	53	4	's	's	POS
cord-253295-82ydczid	53	5	conquest	conquest	NN
cord-253295-82ydczid	53	6	of	of	IN
cord-253295-82ydczid	53	7	Egypt	Egypt	NNP
cord-253295-82ydczid	53	8	in	in	IN
cord-253295-82ydczid	53	9	the	the	DT
cord-253295-82ydczid	53	10	4th	4th	JJ
cord-253295-82ydczid	53	11	century	century	NN
cord-253295-82ydczid	53	12	BC	BC	NNP
cord-253295-82ydczid	53	13	led	lead	VBD
cord-253295-82ydczid	53	14	to	to	IN
cord-253295-82ydczid	53	15	Greek	Greek	NNP
cord-253295-82ydczid	53	16	(	(	-LRB-
cord-253295-82ydczid	53	17	Ptolemaic	Ptolemaic	NNP
cord-253295-82ydczid	53	18	)	)	-RRB-
cord-253295-82ydczid	53	19	leadership	leadership	NN
cord-253295-82ydczid	53	20	of	of	IN
cord-253295-82ydczid	53	21	Egypt	Egypt	NNP
cord-253295-82ydczid	53	22	from	from	IN
cord-253295-82ydczid	53	23	305	305	CD
cord-253295-82ydczid	53	24	BCE	BCE	NNP
cord-253295-82ydczid	53	25	to	to	IN
cord-253295-82ydczid	53	26	30	30	CD
cord-253295-82ydczid	53	27	BCE	BCE	NNP
cord-253295-82ydczid	53	28	,	,	,
cord-253295-82ydczid	53	29	with	with	IN
cord-253295-82ydczid	53	30	development	development	NN
cord-253295-82ydczid	53	31	of	of	IN
cord-253295-82ydczid	53	32	the	the	DT
cord-253295-82ydczid	53	33	Alexandrian	alexandrian	JJ
cord-253295-82ydczid	53	34	library	library	NN
cord-253295-82ydczid	53	35	and	and	CC
cord-253295-82ydczid	53	36	University	University	NNP
cord-253295-82ydczid	53	37	.	.	.
cord-253295-82ydczid	54	1	Faculty	faculty	NN
cord-253295-82ydczid	54	2	such	such	JJ
cord-253295-82ydczid	54	3	as	as	IN
cord-253295-82ydczid	54	4	Euclid	Euclid	NNP
cord-253295-82ydczid	54	5	developed	develop	VBD
cord-253295-82ydczid	54	6	geometric	geometric	JJ
cord-253295-82ydczid	54	7	models	model	NNS
cord-253295-82ydczid	54	8	of	of	IN
cord-253295-82ydczid	54	9	vision	vision	NN
cord-253295-82ydczid	54	10	(	(	-LRB-
cord-253295-82ydczid	54	11	Optica	Optica	NNP
cord-253295-82ydczid	54	12	)	)	-RRB-
cord-253295-82ydczid	54	13	,	,	,
cord-253295-82ydczid	54	14	and	and	CC
cord-253295-82ydczid	54	15	Herophilus	Herophilus	NNP
cord-253295-82ydczid	54	16	described	describe	VBD
cord-253295-82ydczid	54	17	human	human	JJ
cord-253295-82ydczid	54	18	anatomy	anatomy	NN
cord-253295-82ydczid	54	19	by	by	IN
cord-253295-82ydczid	54	20	direct	direct	JJ
cord-253295-82ydczid	54	21	dissection	dissection	NN
cord-253295-82ydczid	54	22	and	and	CC
cord-253295-82ydczid	54	23	observation	observation	NN
cord-253295-82ydczid	54	24	(	(	-LRB-
cord-253295-82ydczid	54	25	Greek	greek	JJ
cord-253295-82ydczid	54	26	medicine	medicine	NN
cord-253295-82ydczid	54	27	apparently	apparently	RB
cord-253295-82ydczid	54	28	allowed	allow	VBD
cord-253295-82ydczid	54	29	dissection	dissection	NN
cord-253295-82ydczid	54	30	in	in	IN
cord-253295-82ydczid	54	31	Alexandria	Alexandria	NNP
cord-253295-82ydczid	54	32	,	,	,
cord-253295-82ydczid	54	33	including	include	VBG
cord-253295-82ydczid	54	34	vivisection	vivisection	NN
cord-253295-82ydczid	54	35	of	of	IN
cord-253295-82ydczid	54	36	the	the	DT
cord-253295-82ydczid	54	37	condemned	condemn	VBN
cord-253295-82ydczid	54	38	)	)	-RRB-
cord-253295-82ydczid	54	39	.	.	.
cord-253295-82ydczid	55	1	During	during	IN
cord-253295-82ydczid	55	2	the	the	DT
cord-253295-82ydczid	55	3	Roman	roman	JJ
cord-253295-82ydczid	55	4	imperial	imperial	JJ
cord-253295-82ydczid	55	5	era	era	NN
cord-253295-82ydczid	55	6	,	,	,
cord-253295-82ydczid	55	7	Galen	Galen	NNP
cord-253295-82ydczid	55	8	(	(	-LRB-
cord-253295-82ydczid	55	9	129À207	129à207	CD
cord-253295-82ydczid	55	10	CE	ce	NN
cord-253295-82ydczid	55	11	)	)	-RRB-
cord-253295-82ydczid	55	12	used	use	VBD
cord-253295-82ydczid	55	13	dissection	dissection	NN
cord-253295-82ydczid	55	14	and	and	CC
cord-253295-82ydczid	55	15	observation	observation	NN
cord-253295-82ydczid	55	16	of	of	IN
cord-253295-82ydczid	55	17	other	other	JJ
cord-253295-82ydczid	55	18	animals	animal	NNS
cord-253295-82ydczid	55	19	such	such	JJ
cord-253295-82ydczid	55	20	as	as	IN
cord-253295-82ydczid	55	21	the	the	DT
cord-253295-82ydczid	55	22	macaque	macaque	NN
cord-253295-82ydczid	55	23	(	(	-LRB-
cord-253295-82ydczid	55	24	human	human	JJ
cord-253295-82ydczid	55	25	dissection	dissection	NN
cord-253295-82ydczid	55	26	was	be	VBD
cord-253295-82ydczid	55	27	illegal	illegal	JJ
cord-253295-82ydczid	55	28	)	)	-RRB-
cord-253295-82ydczid	55	29	to	to	TO
cord-253295-82ydczid	55	30	extrapolate	extrapolate	VB
cord-253295-82ydczid	55	31	to	to	IN
cord-253295-82ydczid	55	32	human	human	JJ
cord-253295-82ydczid	55	33	anatomy	anatomy	NN
cord-253295-82ydczid	55	34	and	and	CC
cord-253295-82ydczid	55	35	physiology	physiology	NN
cord-253295-82ydczid	55	36	.	.	.
cord-253295-82ydczid	56	1	Like	like	IN
cord-253295-82ydczid	56	2	Aristotle	Aristotle	NNP
cord-253295-82ydczid	56	3	's	's	POS
cord-253295-82ydczid	56	4	approach	approach	NN
cord-253295-82ydczid	56	5	,	,	,
cord-253295-82ydczid	56	6	Galen	Galen	NNP
cord-253295-82ydczid	56	7	's	's	POS
cord-253295-82ydczid	56	8	approach	approach	NN
cord-253295-82ydczid	56	9	to	to	IN
cord-253295-82ydczid	56	10	patients	patient	NNS
cord-253295-82ydczid	56	11	,	,	,
cord-253295-82ydczid	56	12	diseases	disease	NNS
cord-253295-82ydczid	56	13	,	,	,
cord-253295-82ydczid	56	14	and	and	CC
cord-253295-82ydczid	56	15	treatments	treatment	NNS
cord-253295-82ydczid	56	16	was	be	VBD
cord-253295-82ydczid	56	17	guided	guide	VBN
cord-253295-82ydczid	56	18	by	by	IN
cord-253295-82ydczid	56	19	philosophical	philosophical	JJ
cord-253295-82ydczid	56	20	constructs	construct	NNS
cord-253295-82ydczid	56	21	of	of	IN
cord-253295-82ydczid	56	22	four	four	CD
cord-253295-82ydczid	56	23	humors	humor	NNS
cord-253295-82ydczid	56	24	(	(	-LRB-
cord-253295-82ydczid	56	25	blood	blood	NN
cord-253295-82ydczid	56	26	,	,	,
cord-253295-82ydczid	56	27	phlegm	phlegm	NN
cord-253295-82ydczid	56	28	,	,	,
cord-253295-82ydczid	56	29	yellow	yellow	JJ
cord-253295-82ydczid	56	30	bile	bile	NN
cord-253295-82ydczid	56	31	,	,	,
cord-253295-82ydczid	56	32	and	and	CC
cord-253295-82ydczid	56	33	black	black	JJ
cord-253295-82ydczid	56	34	bile	bile	NN
cord-253295-82ydczid	56	35	)	)	-RRB-
cord-253295-82ydczid	56	36	and	and	CC
cord-253295-82ydczid	56	37	the	the	DT
cord-253295-82ydczid	56	38	resulting	result	VBG
cord-253295-82ydczid	56	39	temperaments	temperament	NNS
cord-253295-82ydczid	56	40	(	(	-LRB-
cord-253295-82ydczid	56	41	buoyant	buoyant	JJ
cord-253295-82ydczid	56	42	,	,	,
cord-253295-82ydczid	56	43	sluggish	sluggish	JJ
cord-253295-82ydczid	56	44	,	,	,
cord-253295-82ydczid	56	45	quick	quick	JJ
cord-253295-82ydczid	56	46	-	-	HYPH
cord-253295-82ydczid	56	47	tempered	tempered	JJ
cord-253295-82ydczid	56	48	,	,	,
cord-253295-82ydczid	56	49	and	and	CC
cord-253295-82ydczid	56	50	melancholic	melancholic	JJ
cord-253295-82ydczid	56	51	)	)	-RRB-
cord-253295-82ydczid	56	52	due	due	IN
cord-253295-82ydczid	56	53	to	to	IN
cord-253295-82ydczid	56	54	humoral	humoral	JJ
cord-253295-82ydczid	56	55	imbalances	imbalance	NNS
cord-253295-82ydczid	56	56	.	.	.
cord-253295-82ydczid	57	1	It	-PRON-	PRP
cord-253295-82ydczid	57	2	is	be	VBZ
cord-253295-82ydczid	57	3	thought	think	VBN
cord-253295-82ydczid	57	4	that	that	IN
cord-253295-82ydczid	57	5	many	many	JJ
cord-253295-82ydczid	57	6	of	of	IN
cord-253295-82ydczid	57	7	Galen	Galen	NNP
cord-253295-82ydczid	57	8	's	's	POS
cord-253295-82ydczid	57	9	texts	text	NNS
cord-253295-82ydczid	57	10	were	be	VBD
cord-253295-82ydczid	57	11	destroyed	destroy	VBN
cord-253295-82ydczid	57	12	with	with	IN
cord-253295-82ydczid	57	13	the	the	DT
cord-253295-82ydczid	57	14	Alexandrian	alexandrian	JJ
cord-253295-82ydczid	57	15	library	library	NN
cord-253295-82ydczid	57	16	before	before	IN
cord-253295-82ydczid	57	17	the	the	DT
cord-253295-82ydczid	57	18	7th	7th	JJ
cord-253295-82ydczid	57	19	century	century	NN
cord-253295-82ydczid	57	20	AD	ad	NN
cord-253295-82ydczid	57	21	,	,	,
cord-253295-82ydczid	57	22	but	but	CC
cord-253295-82ydczid	57	23	a	a	DT
cord-253295-82ydczid	57	24	subset	subset	NN
cord-253295-82ydczid	57	25	was	be	VBD
cord-253295-82ydczid	57	26	preserved	preserve	VBN
cord-253295-82ydczid	57	27	and	and	CC
cord-253295-82ydczid	57	28	translated	translate	VBN
cord-253295-82ydczid	57	29	by	by	IN
cord-253295-82ydczid	57	30	Middle	middle	JJ
cord-253295-82ydczid	57	31	Eastern	eastern	JJ
cord-253295-82ydczid	57	32	scholars	scholar	NNS
cord-253295-82ydczid	57	33	.	.	.
cord-253295-82ydczid	58	1	These	these	DT
cord-253295-82ydczid	58	2	ancient	ancient	JJ
cord-253295-82ydczid	58	3	classic	classic	JJ
cord-253295-82ydczid	58	4	texts	text	NNS
cord-253295-82ydczid	58	5	were	be	VBD
cord-253295-82ydczid	58	6	then	then	RB
cord-253295-82ydczid	58	7	retranslated	retranslate	VBN
cord-253295-82ydczid	58	8	into	into	IN
cord-253295-82ydczid	58	9	Latin	Latin	NNP
cord-253295-82ydczid	58	10	and	and	CC
cord-253295-82ydczid	58	11	Greek	Greek	NNP
cord-253295-82ydczid	58	12	when	when	WRB
cord-253295-82ydczid	58	13	printing	print	VBG
cord-253295-82ydczid	58	14	houses	house	NNS
cord-253295-82ydczid	58	15	developed	develop	VBN
cord-253295-82ydczid	58	16	in	in	IN
cord-253295-82ydczid	58	17	the	the	DT
cord-253295-82ydczid	58	18	15th	15th	JJ
cord-253295-82ydczid	58	19	century	century	NN
cord-253295-82ydczid	58	20	(	(	-LRB-
cord-253295-82ydczid	58	21	for	for	IN
cord-253295-82ydczid	58	22	instance	instance	NN
cord-253295-82ydczid	58	23	,	,	,
cord-253295-82ydczid	58	24	Hippocrates'De	Hippocrates'De	NNP
cord-253295-82ydczid	58	25	Natura	Natura	NNP
cord-253295-82ydczid	58	26	Hominis	Hominis	NNP
cord-253295-82ydczid	58	27	,	,	,
cord-253295-82ydczid	58	28	circa	circa	NN
cord-253295-82ydczid	58	29	1480	1480	CD
cord-253295-82ydczid	58	30	CE	CE	NNP
cord-253295-82ydczid	58	31	,	,	,
cord-253295-82ydczid	58	32	and	and	CC
cord-253295-82ydczid	58	33	Galen	Galen	NNP
cord-253295-82ydczid	58	34	's	's	POS
cord-253295-82ydczid	58	35	Therapeutica	Therapeutica	NNP
cord-253295-82ydczid	58	36	,	,	,
cord-253295-82ydczid	58	37	circa	circa	NN
cord-253295-82ydczid	58	38	1500	1500	CD
cord-253295-82ydczid	58	39	CE	CE	NNP
cord-253295-82ydczid	58	40	)	)	-RRB-
cord-253295-82ydczid	58	41	.	.	.
cord-253295-82ydczid	59	1	The	the	DT
cord-253295-82ydczid	59	2	historical	historical	JJ
cord-253295-82ydczid	59	3	picture	picture	NN
cord-253295-82ydczid	59	4	of	of	IN
cord-253295-82ydczid	59	5	the	the	DT
cord-253295-82ydczid	59	6	Greco	Greco	NNP
cord-253295-82ydczid	59	7	-	-	HYPH
cord-253295-82ydczid	59	8	Roman	roman	JJ
cord-253295-82ydczid	59	9	understanding	understanding	NN
cord-253295-82ydczid	59	10	of	of	IN
cord-253295-82ydczid	59	11	disease	disease	NN
cord-253295-82ydczid	59	12	is	be	VBZ
cord-253295-82ydczid	59	13	one	one	CD
cord-253295-82ydczid	59	14	of	of	IN
cord-253295-82ydczid	59	15	empirical	empirical	JJ
cord-253295-82ydczid	59	16	approaches	approach	NNS
cord-253295-82ydczid	59	17	to	to	IN
cord-253295-82ydczid	59	18	diseases	disease	NNS
cord-253295-82ydczid	59	19	based	base	VBN
cord-253295-82ydczid	59	20	on	on	IN
cord-253295-82ydczid	59	21	inaccurate	inaccurate	JJ
cord-253295-82ydczid	59	22	understanding	understanding	NN
cord-253295-82ydczid	59	23	of	of	IN
cord-253295-82ydczid	59	24	anatomy	anatomy	NN
cord-253295-82ydczid	59	25	,	,	,
cord-253295-82ydczid	59	26	physiology	physiology	NN
cord-253295-82ydczid	59	27	,	,	,
cord-253295-82ydczid	59	28	and	and	CC
cord-253295-82ydczid	59	29	organ	organ	NN
cord-253295-82ydczid	59	30	/	/	SYM
cord-253295-82ydczid	59	31	cellular	cellular	JJ
cord-253295-82ydczid	59	32	pathology	pathology	NN
cord-253295-82ydczid	59	33	.	.	.
cord-253295-82ydczid	60	1	Greek	greek	JJ
cord-253295-82ydczid	60	2	medicine	medicine	NN
cord-253295-82ydczid	60	3	became	become	VBD
cord-253295-82ydczid	60	4	less	less	RBR
cord-253295-82ydczid	60	5	superstitious	superstitious	JJ
cord-253295-82ydczid	60	6	and	and	CC
cord-253295-82ydczid	60	7	more	more	RBR
cord-253295-82ydczid	60	8	natural	natural	JJ
cord-253295-82ydczid	60	9	cause	cause	NN
cord-253295-82ydczid	60	10	-	-	HYPH
cord-253295-82ydczid	60	11	and	and	CC
cord-253295-82ydczid	60	12	-	-	HYPH
cord-253295-82ydczid	60	13	effect	effect	NN
cord-253295-82ydczid	60	14	oriented	orient	VBN
cord-253295-82ydczid	60	15	,	,	,
cord-253295-82ydczid	60	16	yet	yet	CC
cord-253295-82ydczid	60	17	philosophy	philosophy	NN
cord-253295-82ydczid	60	18	still	still	RB
cord-253295-82ydczid	60	19	trumped	trump	VBD
cord-253295-82ydczid	60	20	direct	direct	JJ
cord-253295-82ydczid	60	21	observation	observation	NN
cord-253295-82ydczid	60	22	,	,	,
cord-253295-82ydczid	60	23	such	such	JJ
cord-253295-82ydczid	60	24	that	that	IN
cord-253295-82ydczid	60	25	evidence	evidence	NN
cord-253295-82ydczid	60	26	was	be	VBD
cord-253295-82ydczid	60	27	constrained	constrain	VBN
cord-253295-82ydczid	60	28	to	to	TO
cord-253295-82ydczid	60	29	fit	fit	VB
cord-253295-82ydczid	60	30	the	the	DT
cord-253295-82ydczid	60	31	classic	classic	JJ
cord-253295-82ydczid	60	32	philosophical	philosophical	JJ
cord-253295-82ydczid	60	33	constructs	construct	NNS
cord-253295-82ydczid	60	34	.	.	.
cord-253295-82ydczid	61	1	Some	some	DT
cord-253295-82ydczid	61	2	of	of	IN
cord-253295-82ydczid	61	3	the	the	DT
cord-253295-82ydczid	61	4	concepts	concept	NNS
cord-253295-82ydczid	61	5	sound	sound	VBP
cord-253295-82ydczid	61	6	familiar	familiar	JJ
cord-253295-82ydczid	61	7	;	;	:
cord-253295-82ydczid	61	8	for	for	IN
cord-253295-82ydczid	61	9	example	example	NN
cord-253295-82ydczid	61	10	,	,	,
cord-253295-82ydczid	61	11	normal	normal	JJ
cord-253295-82ydczid	61	12	represents	represent	VBZ
cord-253295-82ydczid	61	13	equilibrium	equilibrium	NN
cord-253295-82ydczid	61	14	and	and	CC
cord-253295-82ydczid	61	15	disease	disease	NN
cord-253295-82ydczid	61	16	represents	represent	VBZ
cord-253295-82ydczid	61	17	disequilibrium	disequilibrium	NN
cord-253295-82ydczid	61	18	.	.	.
cord-253295-82ydczid	62	1	However	however	RB
cord-253295-82ydczid	62	2	,	,	,
cord-253295-82ydczid	62	3	we	-PRON-	PRP
cord-253295-82ydczid	62	4	would	would	MD
cord-253295-82ydczid	62	5	differ	differ	VB
cord-253295-82ydczid	62	6	on	on	IN
cord-253295-82ydczid	62	7	what	what	WDT
cord-253295-82ydczid	62	8	variables	variable	NNS
cord-253295-82ydczid	62	9	are	be	VBP
cord-253295-82ydczid	62	10	in	in	IN
cord-253295-82ydczid	62	11	disequilibrium	disequilibrium	NN
cord-253295-82ydczid	62	12	(	(	-LRB-
cord-253295-82ydczid	62	13	the	the	DT
cord-253295-82ydczid	62	14	historical	historical	JJ
cord-253295-82ydczid	62	15	humors	humor	NNS
cord-253295-82ydczid	62	16	,	,	,
cord-253295-82ydczid	62	17	numbers	number	NNS
cord-253295-82ydczid	62	18	,	,	,
cord-253295-82ydczid	62	19	and	and	CC
cord-253295-82ydczid	62	20	opposites	opposite	NNS
cord-253295-82ydczid	62	21	versus	versus	IN
cord-253295-82ydczid	62	22	contemporary	contemporary	JJ
cord-253295-82ydczid	62	23	chemical	chemical	NN
cord-253295-82ydczid	62	24	and	and	CC
cord-253295-82ydczid	62	25	kinetic	kinetic	JJ
cord-253295-82ydczid	62	26	equilibria	equilibrium	NNS
cord-253295-82ydczid	62	27	)	)	-RRB-
cord-253295-82ydczid	62	28	.	.	.
cord-253295-82ydczid	63	1	Following	follow	VBG
cord-253295-82ydczid	63	2	the	the	DT
cord-253295-82ydczid	63	3	collapse	collapse	NN
cord-253295-82ydczid	63	4	of	of	IN
cord-253295-82ydczid	63	5	the	the	DT
cord-253295-82ydczid	63	6	Western	Western	NNP
cord-253295-82ydczid	63	7	Roman	Roman	NNP
cord-253295-82ydczid	63	8	Empire	Empire	NNP
cord-253295-82ydczid	63	9	in	in	IN
cord-253295-82ydczid	63	10	476	476	CD
cord-253295-82ydczid	63	11	CE	CE	NNP
cord-253295-82ydczid	63	12	,	,	,
cord-253295-82ydczid	63	13	the	the	DT
cord-253295-82ydczid	63	14	classic	classic	JJ
cord-253295-82ydczid	63	15	texts	text	NNS
cord-253295-82ydczid	63	16	of	of	IN
cord-253295-82ydczid	63	17	Aristotle	Aristotle	NNP
cord-253295-82ydczid	63	18	,	,	,
cord-253295-82ydczid	63	19	Hippocrates	Hippocrates	NNP
cord-253295-82ydczid	63	20	,	,	,
cord-253295-82ydczid	63	21	and	and	CC
cord-253295-82ydczid	63	22	Galen	Galen	NNP
cord-253295-82ydczid	63	23	were	be	VBD
cord-253295-82ydczid	63	24	protected	protect	VBN
cord-253295-82ydczid	63	25	,	,	,
cord-253295-82ydczid	63	26	translated	translate	VBN
cord-253295-82ydczid	63	27	,	,	,
cord-253295-82ydczid	63	28	and	and	CC
cord-253295-82ydczid	63	29	built	build	VBN
cord-253295-82ydczid	63	30	upon	upon	IN
cord-253295-82ydczid	63	31	in	in	IN
cord-253295-82ydczid	63	32	the	the	DT
cord-253295-82ydczid	63	33	Byzantine	byzantine	JJ
cord-253295-82ydczid	63	34	and	and	CC
cord-253295-82ydczid	63	35	Arab	arab	JJ
cord-253295-82ydczid	63	36	societies	society	NNS
cord-253295-82ydczid	63	37	of	of	IN
cord-253295-82ydczid	63	38	the	the	DT
cord-253295-82ydczid	63	39	near	near	JJ
cord-253295-82ydczid	63	40	East	East	NNP
cord-253295-82ydczid	63	41	,	,	,
cord-253295-82ydczid	63	42	and	and	CC
cord-253295-82ydczid	63	43	in	in	IN
cord-253295-82ydczid	63	44	Spain	Spain	NNP
cord-253295-82ydczid	63	45	during	during	IN
cord-253295-82ydczid	63	46	the	the	DT
cord-253295-82ydczid	63	47	Muslim	Muslim	NNP
cord-253295-82ydczid	63	48	/	/	SYM
cord-253295-82ydczid	63	49	Moorish	moorish	JJ
cord-253295-82ydczid	63	50	period	period	NN
cord-253295-82ydczid	63	51	through	through	IN
cord-253295-82ydczid	63	52	the	the	DT
cord-253295-82ydczid	63	53	11th	11th	JJ
cord-253295-82ydczid	63	54	century	century	NN
cord-253295-82ydczid	63	55	.	.	.
cord-253295-82ydczid	64	1	During	during	IN
cord-253295-82ydczid	64	2	these	these	DT
cord-253295-82ydczid	64	3	middle	middle	JJ
cord-253295-82ydczid	64	4	ages	age	NNS
cord-253295-82ydczid	64	5	for	for	IN
cord-253295-82ydczid	64	6	Western	Western	NNP
cord-253295-82ydczid	64	7	Europe	Europe	NNP
cord-253295-82ydczid	64	8	outside	outside	IN
cord-253295-82ydczid	64	9	Spain	Spain	NNP
cord-253295-82ydczid	64	10	,	,	,
cord-253295-82ydczid	64	11	there	there	EX
cord-253295-82ydczid	64	12	was	be	VBD
cord-253295-82ydczid	64	13	apparently	apparently	RB
cord-253295-82ydczid	64	14	a	a	DT
cord-253295-82ydczid	64	15	retreat	retreat	NN
cord-253295-82ydczid	64	16	to	to	TO
cord-253295-82ydczid	64	17	pre	pre	VB
cord-253295-82ydczid	64	18	-	-	JJ
cord-253295-82ydczid	64	19	Hellenistic	hellenistic	JJ
cord-253295-82ydczid	64	20	beliefs	belief	NNS
cord-253295-82ydczid	64	21	in	in	IN
cord-253295-82ydczid	64	22	supernatural	supernatural	JJ
cord-253295-82ydczid	64	23	forces	force	NNS
cord-253295-82ydczid	64	24	that	that	WDT
cord-253295-82ydczid	64	25	intervened	intervene	VBD
cord-253295-82ydczid	64	26	in	in	IN
cord-253295-82ydczid	64	27	human	human	JJ
cord-253295-82ydczid	64	28	affairs	affair	NNS
cord-253295-82ydczid	64	29	,	,	,
cord-253295-82ydczid	64	30	with	with	IN
cord-253295-82ydczid	64	31	protecting	protect	VBG
cord-253295-82ydczid	64	32	saints	saint	NNS
cord-253295-82ydczid	64	33	and	and	CC
cord-253295-82ydczid	64	34	relics	relic	NNS
cord-253295-82ydczid	64	35	for	for	IN
cord-253295-82ydczid	64	36	disease	disease	NN
cord-253295-82ydczid	64	37	prevention	prevention	NN
cord-253295-82ydczid	64	38	and	and	CC
cord-253295-82ydczid	64	39	therapy	therapy	NN
cord-253295-82ydczid	64	40	.	.	.
cord-253295-82ydczid	65	1	Centers	center	NNS
cord-253295-82ydczid	65	2	of	of	IN
cord-253295-82ydczid	65	3	medical	medical	JJ
cord-253295-82ydczid	65	4	learning	learning	NN
cord-253295-82ydczid	65	5	following	follow	VBG
cord-253295-82ydczid	65	6	the	the	DT
cord-253295-82ydczid	65	7	Spanish	spanish	JJ
cord-253295-82ydczid	65	8	Muslim	Muslim	NNP
cord-253295-82ydczid	65	9	model	model	NN
cord-253295-82ydczid	65	10	developed	develop	VBN
cord-253295-82ydczid	65	11	in	in	IN
cord-253295-82ydczid	65	12	Montpellier	Montpellier	NNP
cord-253295-82ydczid	65	13	,	,	,
cord-253295-82ydczid	65	14	France	France	NNP
cord-253295-82ydczid	65	15	,	,	,
cord-253295-82ydczid	65	16	and	and	CC
cord-253295-82ydczid	65	17	in	in	IN
cord-253295-82ydczid	65	18	Salerno	Salerno	NNP
cord-253295-82ydczid	65	19	,	,	,
cord-253295-82ydczid	65	20	Italy	Italy	NNP
cord-253295-82ydczid	65	21	,	,	,
cord-253295-82ydczid	65	22	beginning	begin	VBG
cord-253295-82ydczid	65	23	in	in	IN
cord-253295-82ydczid	65	24	the	the	DT
cord-253295-82ydczid	65	25	11th	11th	JJ
cord-253295-82ydczid	65	26	century	century	NN
cord-253295-82ydczid	65	27	.	.	.
cord-253295-82ydczid	66	1	Aristotle	Aristotle	NNP
cord-253295-82ydczid	66	2	's	's	POS
cord-253295-82ydczid	66	3	concept	concept	NN
cord-253295-82ydczid	66	4	of	of	IN
cord-253295-82ydczid	66	5	induction	induction	NN
cord-253295-82ydczid	66	6	from	from	IN
cord-253295-82ydczid	66	7	particulars	particular	NNS
cord-253295-82ydczid	66	8	to	to	IN
cord-253295-82ydczid	66	9	general	general	JJ
cord-253295-82ydczid	66	10	first	first	JJ
cord-253295-82ydczid	66	11	principles	principle	NNS
cord-253295-82ydczid	66	12	,	,	,
cord-253295-82ydczid	66	13	then	then	RB
cord-253295-82ydczid	66	14	use	use	NN
cord-253295-82ydczid	66	15	of	of	IN
cord-253295-82ydczid	66	16	syllogistic	syllogistic	JJ
cord-253295-82ydczid	66	17	logic	logic	NN
cord-253295-82ydczid	66	18	to	to	TO
cord-253295-82ydczid	66	19	predict	predict	VB
cord-253295-82ydczid	66	20	particulars	particular	NNS
cord-253295-82ydczid	66	21	,	,	,
cord-253295-82ydczid	66	22	evolved	evolve	VBD
cord-253295-82ydczid	66	23	into	into	IN
cord-253295-82ydczid	66	24	the	the	DT
cord-253295-82ydczid	66	25	scientific	scientific	JJ
cord-253295-82ydczid	66	26	method	method	NN
cord-253295-82ydczid	66	27	during	during	IN
cord-253295-82ydczid	66	28	the	the	DT
cord-253295-82ydczid	66	29	Renaissance	Renaissance	NNP
cord-253295-82ydczid	66	30	.	.	.
cord-253295-82ydczid	67	1	Ibn	Ibn	NNP
cord-253295-82ydczid	67	2	Alhazen	Alhazen	NNP
cord-253295-82ydczid	67	3	's	's	POS
cord-253295-82ydczid	67	4	(	(	-LRB-
cord-253295-82ydczid	67	5	al	al	NNP
cord-253295-82ydczid	67	6	-	-	HYPH
cord-253295-82ydczid	67	7	Haitham	Haitham	NNP
cord-253295-82ydczid	67	8	's	's	POS
cord-253295-82ydczid	67	9	)	)	-RRB-
cord-253295-82ydczid	67	10	work	work	VB
cord-253295-82ydczid	67	11	on	on	IN
cord-253295-82ydczid	67	12	the	the	DT
cord-253295-82ydczid	67	13	physics	physics	NN
cord-253295-82ydczid	67	14	of	of	IN
cord-253295-82ydczid	67	15	optics	optic	NNS
cord-253295-82ydczid	67	16	in	in	IN
cord-253295-82ydczid	67	17	the	the	DT
cord-253295-82ydczid	67	18	11th	11th	JJ
cord-253295-82ydczid	67	19	century	century	NN
cord-253295-82ydczid	67	20	challenged	challenge	VBD
cord-253295-82ydczid	67	21	Euclid	Euclid	NNP
cord-253295-82ydczid	67	22	's	's	POS
cord-253295-82ydczid	67	23	concepts	concept	NNS
cord-253295-82ydczid	67	24	of	of	IN
cord-253295-82ydczid	67	25	vision	vision	NN
cord-253295-82ydczid	67	26	from	from	IN
cord-253295-82ydczid	67	27	the	the	DT
cord-253295-82ydczid	67	28	Alexandrian	alexandrian	JJ
cord-253295-82ydczid	67	29	era	era	NN
cord-253295-82ydczid	67	30	.	.	.
cord-253295-82ydczid	68	1	(	(	-LRB-
cord-253295-82ydczid	68	2	Euclid	Euclid	NNP
cord-253295-82ydczid	68	3	thought	think	VBD
cord-253295-82ydczid	68	4	that	that	IN
cord-253295-82ydczid	68	5	the	the	DT
cord-253295-82ydczid	68	6	eye	eye	NN
cord-253295-82ydczid	68	7	generated	generate	VBD
cord-253295-82ydczid	68	8	the	the	DT
cord-253295-82ydczid	68	9	image	image	NN
cord-253295-82ydczid	68	10	,	,	,
cord-253295-82ydczid	68	11	rather	rather	RB
cord-253295-82ydczid	68	12	than	than	IN
cord-253295-82ydczid	68	13	light	light	NN
cord-253295-82ydczid	68	14	reflected	reflect	VBN
cord-253295-82ydczid	68	15	from	from	IN
cord-253295-82ydczid	68	16	the	the	DT
cord-253295-82ydczid	68	17	object	object	NN
cord-253295-82ydczid	68	18	being	be	VBG
cord-253295-82ydczid	68	19	received	receive	VBN
cord-253295-82ydczid	68	20	by	by	IN
cord-253295-82ydczid	68	21	the	the	DT
cord-253295-82ydczid	68	22	eye	eye	NN
cord-253295-82ydczid	68	23	)	)	-RRB-
cord-253295-82ydczid	68	24	.	.	.
cord-253295-82ydczid	69	1	In	in	IN
cord-253295-82ydczid	69	2	the	the	DT
cord-253295-82ydczid	69	3	13th	13th	JJ
cord-253295-82ydczid	69	4	century	century	NN
cord-253295-82ydczid	69	5	,	,	,
cord-253295-82ydczid	69	6	Roger	Roger	NNP
cord-253295-82ydczid	69	7	Bacon	Bacon	NNP
cord-253295-82ydczid	69	8	reinforced	reinforce	VBD
cord-253295-82ydczid	69	9	this	this	DT
cord-253295-82ydczid	69	10	use	use	NN
cord-253295-82ydczid	69	11	of	of	IN
cord-253295-82ydczid	69	12	observation	observation	NN
cord-253295-82ydczid	69	13	,	,	,
cord-253295-82ydczid	69	14	hypothesis	hypothesis	NN
cord-253295-82ydczid	69	15	,	,	,
cord-253295-82ydczid	69	16	and	and	CC
cord-253295-82ydczid	69	17	experimentation	experimentation	NN
cord-253295-82ydczid	69	18	.	.	.
cord-253295-82ydczid	70	1	The	the	DT
cord-253295-82ydczid	70	2	printing	printing	NN
cord-253295-82ydczid	70	3	press	press	NN
cord-253295-82ydczid	70	4	(	(	-LRB-
cord-253295-82ydczid	70	5	Gutenberg	Gutenberg	NNP
cord-253295-82ydczid	70	6	,	,	,
cord-253295-82ydczid	70	7	1440	1440	CD
cord-253295-82ydczid	70	8	CE	CE	NNP
cord-253295-82ydczid	70	9	)	)	-RRB-
cord-253295-82ydczid	70	10	allowed	allow	VBD
cord-253295-82ydczid	70	11	document	document	NN
cord-253295-82ydczid	70	12	standardization	standardization	NN
cord-253295-82ydczid	70	13	and	and	CC
cord-253295-82ydczid	70	14	reproduction	reproduction	NN
cord-253295-82ydczid	70	15	,	,	,
cord-253295-82ydczid	70	16	such	such	JJ
cord-253295-82ydczid	70	17	that	that	IN
cord-253295-82ydczid	70	18	multiple	multiple	JJ
cord-253295-82ydczid	70	19	parallel	parallel	JJ
cord-253295-82ydczid	70	20	university	university	NN
cord-253295-82ydczid	70	21	and	and	CC
cord-253295-82ydczid	70	22	city	city	NN
cord-253295-82ydczid	70	23	libraries	library	NNS
cord-253295-82ydczid	70	24	could	could	MD
cord-253295-82ydczid	70	25	afford	afford	VB
cord-253295-82ydczid	70	26	to	to	TO
cord-253295-82ydczid	70	27	have	have	VB
cord-253295-82ydczid	70	28	similar	similar	JJ
cord-253295-82ydczid	70	29	collections	collection	NNS
cord-253295-82ydczid	70	30	of	of	IN
cord-253295-82ydczid	70	31	critical	critical	JJ
cord-253295-82ydczid	70	32	texts	text	NNS
cord-253295-82ydczid	70	33	,	,	,
cord-253295-82ydczid	70	34	facilitating	facilitate	VBG
cord-253295-82ydczid	70	35	scholarly	scholarly	JJ
cord-253295-82ydczid	70	36	publications	publication	NNS
cord-253295-82ydczid	70	37	in	in	IN
cord-253295-82ydczid	70	38	journals	journal	NNS
cord-253295-82ydczid	70	39	.	.	.
cord-253295-82ydczid	71	1	Access	access	NN
cord-253295-82ydczid	71	2	to	to	IN
cord-253295-82ydczid	71	3	publications	publication	NNS
cord-253295-82ydczid	71	4	in	in	IN
cord-253295-82ydczid	71	5	libraries	library	NNS
cord-253295-82ydczid	71	6	and	and	CC
cord-253295-82ydczid	71	7	universities	university	NNS
cord-253295-82ydczid	71	8	led	lead	VBD
cord-253295-82ydczid	71	9	to	to	IN
cord-253295-82ydczid	71	10	a	a	DT
cord-253295-82ydczid	71	11	system	system	NN
cord-253295-82ydczid	71	12	of	of	IN
cord-253295-82ydczid	71	13	review	review	NN
cord-253295-82ydczid	71	14	,	,	,
cord-253295-82ydczid	71	15	demonstration	demonstration	NN
cord-253295-82ydczid	71	16	,	,	,
cord-253295-82ydczid	71	17	discussion	discussion	NN
cord-253295-82ydczid	71	18	,	,	,
cord-253295-82ydczid	71	19	and	and	CC
cord-253295-82ydczid	71	20	consensus	consensus	NN
cord-253295-82ydczid	71	21	regarding	regard	VBG
cord-253295-82ydczid	71	22	new	new	JJ
cord-253295-82ydczid	71	23	scientific	scientific	JJ
cord-253295-82ydczid	71	24	findings	finding	NNS
cord-253295-82ydczid	71	25	.	.	.
cord-253295-82ydczid	72	1	The	the	DT
cord-253295-82ydczid	72	2	concept	concept	NN
cord-253295-82ydczid	72	3	of	of	IN
cord-253295-82ydczid	72	4	the	the	DT
cord-253295-82ydczid	72	5	body	body	NN
cord-253295-82ydczid	72	6	as	as	IN
cord-253295-82ydczid	72	7	an	an	DT
cord-253295-82ydczid	72	8	elegant	elegant	JJ
cord-253295-82ydczid	72	9	machine	machine	NN
cord-253295-82ydczid	72	10	was	be	VBD
cord-253295-82ydczid	72	11	captured	capture	VBN
cord-253295-82ydczid	72	12	by	by	IN
cord-253295-82ydczid	72	13	not	not	RB
cord-253295-82ydczid	72	14	only	only	RB
cord-253295-82ydczid	72	15	15th	15th	JJ
cord-253295-82ydczid	72	16	and	and	CC
cord-253295-82ydczid	72	17	16th	16th	JJ
cord-253295-82ydczid	72	18	century	century	NN
cord-253295-82ydczid	72	19	Renaissance	Renaissance	NNP
cord-253295-82ydczid	72	20	artists	artist	NNS
cord-253295-82ydczid	72	21	like	like	IN
cord-253295-82ydczid	72	22	da	da	NNP
cord-253295-82ydczid	72	23	Vinci	Vinci	NNP
cord-253295-82ydczid	72	24	and	and	CC
cord-253295-82ydczid	72	25	Michelangelo	Michelangelo	NNP
cord-253295-82ydczid	72	26	,	,	,
cord-253295-82ydczid	72	27	but	but	CC
cord-253295-82ydczid	72	28	also	also	RB
cord-253295-82ydczid	72	29	by	by	IN
cord-253295-82ydczid	72	30	anatomists	anatomist	NNS
cord-253295-82ydczid	72	31	and	and	CC
cord-253295-82ydczid	72	32	pathologists	pathologist	NNS
cord-253295-82ydczid	72	33	interested	interested	JJ
cord-253295-82ydczid	72	34	in	in	IN
cord-253295-82ydczid	72	35	the	the	DT
cord-253295-82ydczid	72	36	structure	structure	NN
cord-253295-82ydczid	72	37	/	/	SYM
cord-253295-82ydczid	72	38	function	function	NN
cord-253295-82ydczid	72	39	of	of	IN
cord-253295-82ydczid	72	40	health	health	NN
cord-253295-82ydczid	72	41	and	and	CC
cord-253295-82ydczid	72	42	disease	disease	NN
cord-253295-82ydczid	72	43	.	.	.
cord-253295-82ydczid	73	1	The	the	DT
cord-253295-82ydczid	73	2	ancient	ancient	JJ
cord-253295-82ydczid	73	3	models	model	NNS
cord-253295-82ydczid	73	4	of	of	IN
cord-253295-82ydczid	73	5	Aristotle	Aristotle	NNP
cord-253295-82ydczid	73	6	and	and	CC
cord-253295-82ydczid	73	7	Galen	Galen	NNP
cord-253295-82ydczid	73	8	had	have	VBD
cord-253295-82ydczid	73	9	become	become	VBN
cord-253295-82ydczid	73	10	sacrosanct	sacrosanct	JJ
cord-253295-82ydczid	73	11	,	,	,
cord-253295-82ydczid	73	12	and	and	CC
cord-253295-82ydczid	73	13	newer	new	JJR
cord-253295-82ydczid	73	14	,	,	,
cord-253295-82ydczid	73	15	evidence	evidence	NN
cord-253295-82ydczid	73	16	-	-	HYPH
cord-253295-82ydczid	73	17	based	base	VBN
cord-253295-82ydczid	73	18	models	model	NNS
cord-253295-82ydczid	73	19	were	be	VBD
cord-253295-82ydczid	73	20	considered	consider	VBN
cord-253295-82ydczid	73	21	heretical	heretical	JJ
cord-253295-82ydczid	73	22	to	to	IN
cord-253295-82ydczid	73	23	some	some	DT
cord-253295-82ydczid	73	24	degree	degree	NN
cord-253295-82ydczid	73	25	.	.	.
cord-253295-82ydczid	74	1	So	so	RB
cord-253295-82ydczid	74	2	it	-PRON-	PRP
cord-253295-82ydczid	74	3	was	be	VBD
cord-253295-82ydczid	74	4	somewhat	somewhat	RB
cord-253295-82ydczid	74	5	revolutionary	revolutionary	JJ
cord-253295-82ydczid	74	6	when	when	WRB
cord-253295-82ydczid	74	7	Vesalius	Vesalius	NNP
cord-253295-82ydczid	74	8	dissected	dissect	VBD
cord-253295-82ydczid	74	9	corpses	corpse	NNS
cord-253295-82ydczid	74	10	,	,	,
cord-253295-82ydczid	74	11	compared	compare	VBD
cord-253295-82ydczid	74	12	them	-PRON-	PRP
cord-253295-82ydczid	74	13	with	with	IN
cord-253295-82ydczid	74	14	Galenic	Galenic	NNP
cord-253295-82ydczid	74	15	descriptions	description	NNS
cord-253295-82ydczid	74	16	,	,	,
cord-253295-82ydczid	74	17	and	and	CC
cord-253295-82ydczid	74	18	published	publish	VBN
cord-253295-82ydczid	74	19	De	De	NNP
cord-253295-82ydczid	74	20	humani	humani	FW
cord-253295-82ydczid	74	21	corporis	corporis	FW
cord-253295-82ydczid	74	22	fabrica	fabrica	NNP
cord-253295-82ydczid	74	23	libri	libri	NNP
cord-253295-82ydczid	74	24	septem	septem	NNP
cord-253295-82ydczid	74	25	(	(	-LRB-
cord-253295-82ydczid	74	26	1543	1543	CD
cord-253295-82ydczid	74	27	CE	CE	NNP
cord-253295-82ydczid	74	28	;	;	:
cord-253295-82ydczid	74	29	"	"	``
cord-253295-82ydczid	74	30	Seven	seven	CD
cord-253295-82ydczid	74	31	Books	book	NNS
cord-253295-82ydczid	74	32	on	on	IN
cord-253295-82ydczid	74	33	the	the	DT
cord-253295-82ydczid	74	34	Structure	Structure	NNP
cord-253295-82ydczid	74	35	of	of	IN
cord-253295-82ydczid	74	36	the	the	DT
cord-253295-82ydczid	74	37	Human	Human	NNP
cord-253295-82ydczid	74	38	Body	Body	NNP
cord-253295-82ydczid	74	39	"	"	''
cord-253295-82ydczid	74	40	;	;	:
cord-253295-82ydczid	74	41	the	the	DT
cord-253295-82ydczid	74	42	Fabrica	Fabrica	NNP
cord-253295-82ydczid	74	43	)	)	-RRB-
cord-253295-82ydczid	74	44	,	,	,
cord-253295-82ydczid	74	45	challenging	challenge	VBG
cord-253295-82ydczid	74	46	and	and	CC
cord-253295-82ydczid	74	47	correcting	correct	VBG
cord-253295-82ydczid	74	48	16th	16th	JJ
cord-253295-82ydczid	74	49	century	century	NN
cord-253295-82ydczid	74	50	understanding	understanding	NN
cord-253295-82ydczid	74	51	of	of	IN
cord-253295-82ydczid	74	52	normal	normal	JJ
cord-253295-82ydczid	74	53	human	human	JJ
cord-253295-82ydczid	74	54	anatomy	anatomy	NN
cord-253295-82ydczid	74	55	.	.	.
cord-253295-82ydczid	75	1	Vesalius	Vesalius	NNP
cord-253295-82ydczid	75	2	's	's	POS
cord-253295-82ydczid	75	3	successors	successor	NNS
cord-253295-82ydczid	75	4	(	(	-LRB-
cord-253295-82ydczid	75	5	Colombo	Colombo	NNP
cord-253295-82ydczid	75	6	,	,	,
cord-253295-82ydczid	75	7	Fallopius	Fallopius	NNP
cord-253295-82ydczid	75	8	,	,	,
cord-253295-82ydczid	75	9	and	and	CC
cord-253295-82ydczid	75	10	Eustachius	Eustachius	NNP
cord-253295-82ydczid	75	11	)	)	-RRB-
cord-253295-82ydczid	75	12	further	further	RB
cord-253295-82ydczid	75	13	improved	improve	VBD
cord-253295-82ydczid	75	14	the	the	DT
cord-253295-82ydczid	75	15	accuracy	accuracy	NN
cord-253295-82ydczid	75	16	of	of	IN
cord-253295-82ydczid	75	17	human	human	JJ
cord-253295-82ydczid	75	18	anatomic	anatomic	JJ
cord-253295-82ydczid	75	19	detail	detail	NN
cord-253295-82ydczid	75	20	.	.	.
cord-253295-82ydczid	76	1	Thus	thus	RB
cord-253295-82ydczid	76	2	,	,	,
cord-253295-82ydczid	76	3	correction	correction	NN
cord-253295-82ydczid	76	4	of	of	IN
cord-253295-82ydczid	76	5	Galen	Galen	NNP
cord-253295-82ydczid	76	6	's	's	POS
cord-253295-82ydczid	76	7	anatomical	anatomical	JJ
cord-253295-82ydczid	76	8	inaccuracies	inaccuracy	NNS
cord-253295-82ydczid	76	9	(	(	-LRB-
cord-253295-82ydczid	76	10	including	include	VBG
cord-253295-82ydczid	76	11	the	the	DT
cord-253295-82ydczid	76	12	rete	rete	FW
cord-253295-82ydczid	76	13	mirabile	mirabile	NN
cord-253295-82ydczid	76	14	at	at	IN
cord-253295-82ydczid	76	15	the	the	DT
cord-253295-82ydczid	76	16	base	base	NN
cord-253295-82ydczid	76	17	of	of	IN
cord-253295-82ydczid	76	18	the	the	DT
cord-253295-82ydczid	76	19	brain	brain	NN
cord-253295-82ydczid	76	20	,	,	,
cord-253295-82ydczid	76	21	blood	blood	NN
cord-253295-82ydczid	76	22	vasculature	vasculature	NN
cord-253295-82ydczid	76	23	,	,	,
cord-253295-82ydczid	76	24	the	the	DT
cord-253295-82ydczid	76	25	five	five	CD
cord-253295-82ydczid	76	26	lobed	lobed	JJ
cord-253295-82ydczid	76	27	liver	liver	NN
cord-253295-82ydczid	76	28	,	,	,
cord-253295-82ydczid	76	29	and	and	CC
cord-253295-82ydczid	76	30	curved	curved	JJ
cord-253295-82ydczid	76	31	humerus	humerus	NN
cord-253295-82ydczid	76	32	)	)	-RRB-
cord-253295-82ydczid	76	33	required	require	VBN
cord-253295-82ydczid	76	34	at	at	IN
cord-253295-82ydczid	76	35	least	least	RBS
cord-253295-82ydczid	76	36	13	13	CD
cord-253295-82ydczid	76	37	centuries	century	NNS
cord-253295-82ydczid	76	38	for	for	IN
cord-253295-82ydczid	76	39	challenge	challenge	NN
cord-253295-82ydczid	76	40	,	,	,
cord-253295-82ydczid	76	41	scientific	scientific	JJ
cord-253295-82ydczid	76	42	disproof	disproof	NN
cord-253295-82ydczid	76	43	,	,	,
cord-253295-82ydczid	76	44	and	and	CC
cord-253295-82ydczid	76	45	eventual	eventual	JJ
cord-253295-82ydczid	76	46	medical	medical	JJ
cord-253295-82ydczid	76	47	community	community	NN
cord-253295-82ydczid	76	48	acceptance	acceptance	NN
cord-253295-82ydczid	76	49	.	.	.
cord-253295-82ydczid	77	1	The	the	DT
cord-253295-82ydczid	77	2	Scientific	Scientific	NNP
cord-253295-82ydczid	77	3	Revolution	Revolution	NNP
cord-253295-82ydczid	77	4	describes	describe	VBZ
cord-253295-82ydczid	77	5	the	the	DT
cord-253295-82ydczid	77	6	progressive	progressive	JJ
cord-253295-82ydczid	77	7	change	change	NN
cord-253295-82ydczid	77	8	in	in	IN
cord-253295-82ydczid	77	9	attitude	attitude	NN
cord-253295-82ydczid	77	10	of	of	IN
cord-253295-82ydczid	77	11	scientists	scientist	NNS
cord-253295-82ydczid	77	12	and	and	CC
cord-253295-82ydczid	77	13	physicians	physician	NNS
cord-253295-82ydczid	77	14	toward	toward	IN
cord-253295-82ydczid	77	15	understanding	understanding	NN
cord-253295-82ydczid	77	16	of	of	IN
cord-253295-82ydczid	77	17	the	the	DT
cord-253295-82ydczid	77	18	natural	natural	JJ
cord-253295-82ydczid	77	19	world	world	NN
cord-253295-82ydczid	77	20	,	,	,
cord-253295-82ydczid	77	21	health	health	NN
cord-253295-82ydczid	77	22	,	,	,
cord-253295-82ydczid	77	23	and	and	CC
cord-253295-82ydczid	77	24	disease	disease	NN
cord-253295-82ydczid	77	25	.	.	.
cord-253295-82ydczid	78	1	This	this	DT
cord-253295-82ydczid	78	2	revolution	revolution	NN
cord-253295-82ydczid	78	3	began	begin	VBD
cord-253295-82ydczid	78	4	circa	circa	NN
cord-253295-82ydczid	78	5	1543	1543	CD
cord-253295-82ydczid	78	6	CE	CE	NNP
cord-253295-82ydczid	78	7	,	,	,
cord-253295-82ydczid	78	8	when	when	WRB
cord-253295-82ydczid	78	9	Copernicus	Copernicus	NNP
cord-253295-82ydczid	78	10	published	publish	VBD
cord-253295-82ydczid	78	11	arguments	argument	NNS
cord-253295-82ydczid	78	12	for	for	IN
cord-253295-82ydczid	78	13	a	a	DT
cord-253295-82ydczid	78	14	heliocentric	heliocentric	JJ
cord-253295-82ydczid	78	15	universe	universe	NN
cord-253295-82ydczid	78	16	and	and	CC
cord-253295-82ydczid	78	17	Vesalius	Vesalius	NNP
cord-253295-82ydczid	78	18	published	publish	VBD
cord-253295-82ydczid	78	19	the	the	DT
cord-253295-82ydczid	78	20	Fabrica	Fabrica	NNP
cord-253295-82ydczid	78	21	series	series	NN
cord-253295-82ydczid	78	22	on	on	IN
cord-253295-82ydczid	78	23	human	human	JJ
cord-253295-82ydczid	78	24	anatomy	anatomy	NN
cord-253295-82ydczid	78	25	.	.	.
cord-253295-82ydczid	79	1	By	by	IN
cord-253295-82ydczid	79	2	the	the	DT
cord-253295-82ydczid	79	3	17th	17th	JJ
cord-253295-82ydczid	79	4	century	century	NN
cord-253295-82ydczid	79	5	,	,	,
cord-253295-82ydczid	79	6	Galileo	Galileo	NNP
cord-253295-82ydczid	79	7	,	,	,
cord-253295-82ydczid	79	8	Kepler	Kepler	NNP
cord-253295-82ydczid	79	9	,	,	,
cord-253295-82ydczid	79	10	Newton	Newton	NNP
cord-253295-82ydczid	79	11	,	,	,
cord-253295-82ydczid	79	12	Harvey	Harvey	NNP
cord-253295-82ydczid	79	13	,	,	,
cord-253295-82ydczid	79	14	and	and	CC
cord-253295-82ydczid	79	15	others	other	NNS
cord-253295-82ydczid	79	16	had	have	VBD
cord-253295-82ydczid	79	17	used	use	VBN
cord-253295-82ydczid	79	18	this	this	DT
cord-253295-82ydczid	79	19	observation	observation	NN
cord-253295-82ydczid	79	20	-	-	HYPH
cord-253295-82ydczid	79	21	based	base	VBN
cord-253295-82ydczid	79	22	,	,	,
cord-253295-82ydczid	79	23	matter	matter	NN
cord-253295-82ydczid	79	24	-	-	HYPH
cord-253295-82ydczid	79	25	based	base	VBN
cord-253295-82ydczid	79	26	,	,	,
cord-253295-82ydczid	79	27	and	and	CC
cord-253295-82ydczid	79	28	mathematical	mathematical	JJ
cord-253295-82ydczid	79	29	law	law	NN
cord-253295-82ydczid	79	30	-	-	HYPH
cord-253295-82ydczid	79	31	based	base	VBN
cord-253295-82ydczid	79	32	perspective	perspective	NN
cord-253295-82ydczid	79	33	to	to	TO
cord-253295-82ydczid	79	34	develop	develop	VB
cord-253295-82ydczid	79	35	a	a	DT
cord-253295-82ydczid	79	36	scientific	scientific	JJ
cord-253295-82ydczid	79	37	approach	approach	NN
cord-253295-82ydczid	79	38	similar	similar	JJ
cord-253295-82ydczid	79	39	to	to	IN
cord-253295-82ydczid	79	40	our	-PRON-	PRP$
cord-253295-82ydczid	79	41	own	own	JJ
cord-253295-82ydczid	79	42	modern	modern	JJ
cord-253295-82ydczid	79	43	approach	approach	NN
cord-253295-82ydczid	79	44	of	of	IN
cord-253295-82ydczid	79	45	testing	test	VBG
cord-253295-82ydczid	79	46	hypotheses	hypothesis	NNS
cord-253295-82ydczid	79	47	with	with	IN
cord-253295-82ydczid	79	48	experimental	experimental	JJ
cord-253295-82ydczid	79	49	data	datum	NNS
cord-253295-82ydczid	79	50	and	and	CC
cord-253295-82ydczid	79	51	statistics	statistic	NNS
cord-253295-82ydczid	79	52	.	.	.
cord-253295-82ydczid	80	1	In	in	IN
cord-253295-82ydczid	80	2	human	human	JJ
cord-253295-82ydczid	80	3	biology	biology	NN
cord-253295-82ydczid	80	4	,	,	,
cord-253295-82ydczid	80	5	the	the	DT
cord-253295-82ydczid	80	6	investigation	investigation	NN
cord-253295-82ydczid	80	7	of	of	IN
cord-253295-82ydczid	80	8	structure	structure	NN
cord-253295-82ydczid	80	9	led	lead	VBD
cord-253295-82ydczid	80	10	to	to	IN
cord-253295-82ydczid	80	11	studies	study	NNS
cord-253295-82ydczid	80	12	of	of	IN
cord-253295-82ydczid	80	13	function	function	NN
cord-253295-82ydczid	80	14	,	,	,
cord-253295-82ydczid	80	15	initially	initially	RB
cord-253295-82ydczid	80	16	of	of	IN
cord-253295-82ydczid	80	17	human	human	JJ
cord-253295-82ydczid	80	18	cardiovascular	cardiovascular	JJ
cord-253295-82ydczid	80	19	physiology	physiology	NN
cord-253295-82ydczid	80	20	,	,	,
cord-253295-82ydczid	80	21	for	for	IN
cord-253295-82ydczid	80	22	example	example	NN
cord-253295-82ydczid	80	23	,	,	,
cord-253295-82ydczid	80	24	Harvey	Harvey	NNP
cord-253295-82ydczid	80	25	's	's	POS
cord-253295-82ydczid	80	26	Anatomical	anatomical	JJ
cord-253295-82ydczid	80	27	Exercise	exercise	NN
cord-253295-82ydczid	81	1	Concerning	concern	VBG
cord-253295-82ydczid	81	2	the	the	DT
cord-253295-82ydczid	81	3	Motion	Motion	NNP
cord-253295-82ydczid	81	4	of	of	IN
cord-253295-82ydczid	81	5	the	the	DT
cord-253295-82ydczid	81	6	Heart	Heart	NNP
cord-253295-82ydczid	81	7	and	and	CC
cord-253295-82ydczid	81	8	Blood	blood	NN
cord-253295-82ydczid	81	9	in	in	IN
cord-253295-82ydczid	81	10	Animals	animal	NNS
cord-253295-82ydczid	81	11	(	(	-LRB-
cord-253295-82ydczid	81	12	1628	1628	CD
cord-253295-82ydczid	81	13	)	)	-RRB-
cord-253295-82ydczid	81	14	.	.	.
cord-253295-82ydczid	82	1	Whereas	whereas	IN
cord-253295-82ydczid	82	2	Galen	Galen	NNP
cord-253295-82ydczid	82	3	conceived	conceive	VBD
cord-253295-82ydczid	82	4	of	of	IN
cord-253295-82ydczid	82	5	parallel	parallel	JJ
cord-253295-82ydczid	82	6	but	but	CC
cord-253295-82ydczid	82	7	unconnected	unconnected	JJ
cord-253295-82ydczid	82	8	arteries	artery	NNS
cord-253295-82ydczid	82	9	and	and	CC
cord-253295-82ydczid	82	10	veins	vein	NNS
cord-253295-82ydczid	82	11	,	,	,
cord-253295-82ydczid	82	12	with	with	IN
cord-253295-82ydczid	82	13	continuous	continuous	JJ
cord-253295-82ydczid	82	14	blood	blood	NN
cord-253295-82ydczid	82	15	production	production	NN
cord-253295-82ydczid	82	16	in	in	IN
cord-253295-82ydczid	82	17	the	the	DT
cord-253295-82ydczid	82	18	liver	liver	NN
cord-253295-82ydczid	82	19	and	and	CC
cord-253295-82ydczid	82	20	continuous	continuous	JJ
cord-253295-82ydczid	82	21	blood	blood	NN
cord-253295-82ydczid	82	22	consumption	consumption	NN
cord-253295-82ydczid	82	23	in	in	IN
cord-253295-82ydczid	82	24	the	the	DT
cord-253295-82ydczid	82	25	periphery	periphery	NN
cord-253295-82ydczid	82	26	,	,	,
cord-253295-82ydczid	82	27	Harvey	Harvey	NNP
cord-253295-82ydczid	82	28	demonstrated	demonstrate	VBD
cord-253295-82ydczid	82	29	that	that	IN
cord-253295-82ydczid	82	30	blood	blood	NN
cord-253295-82ydczid	82	31	was	be	VBD
cord-253295-82ydczid	82	32	pumped	pump	VBN
cord-253295-82ydczid	82	33	by	by	IN
cord-253295-82ydczid	82	34	the	the	DT
cord-253295-82ydczid	82	35	heart	heart	NN
cord-253295-82ydczid	82	36	through	through	IN
cord-253295-82ydczid	82	37	arteries	artery	NNS
cord-253295-82ydczid	82	38	,	,	,
cord-253295-82ydczid	82	39	through	through	IN
cord-253295-82ydczid	82	40	tissue	tissue	NN
cord-253295-82ydczid	82	41	capillaries	capillary	NNS
cord-253295-82ydczid	82	42	,	,	,
cord-253295-82ydczid	82	43	to	to	IN
cord-253295-82ydczid	82	44	veins	vein	NNS
cord-253295-82ydczid	82	45	,	,	,
cord-253295-82ydczid	82	46	and	and	CC
cord-253295-82ydczid	82	47	then	then	RB
cord-253295-82ydczid	82	48	back	back	RB
cord-253295-82ydczid	82	49	to	to	IN
cord-253295-82ydczid	82	50	the	the	DT
cord-253295-82ydczid	82	51	heart	heart	NN
cord-253295-82ydczid	82	52	in	in	IN
cord-253295-82ydczid	82	53	a	a	DT
cord-253295-82ydczid	82	54	circle	circle	NN
cord-253295-82ydczid	82	55	(	(	-LRB-
cord-253295-82ydczid	82	56	circulation	circulation	NN
cord-253295-82ydczid	82	57	)	)	-RRB-
cord-253295-82ydczid	82	58	.	.	.
cord-253295-82ydczid	83	1	Correction	correction	NN
cord-253295-82ydczid	83	2	of	of	IN
cord-253295-82ydczid	83	3	these	these	DT
cord-253295-82ydczid	83	4	and	and	CC
cord-253295-82ydczid	83	5	other	other	JJ
cord-253295-82ydczid	83	6	Galenic	Galenic	NNP
cord-253295-82ydczid	83	7	physiological	physiological	JJ
cord-253295-82ydczid	83	8	inaccuracies	inaccuracy	NNS
cord-253295-82ydczid	83	9	(	(	-LRB-
cord-253295-82ydczid	83	10	such	such	JJ
cord-253295-82ydczid	83	11	as	as	IN
cord-253295-82ydczid	83	12	nasal	nasal	JJ
cord-253295-82ydczid	83	13	secretions	secretion	NNS
cord-253295-82ydczid	83	14	representing	represent	VBG
cord-253295-82ydczid	83	15	the	the	DT
cord-253295-82ydczid	83	16	filtrate	filtrate	NN
cord-253295-82ydczid	83	17	of	of	IN
cord-253295-82ydczid	83	18	cerebral	cerebral	JJ
cord-253295-82ydczid	83	19	ventricle	ventricle	NNP
cord-253295-82ydczid	83	20	fluid	fluid	NN
cord-253295-82ydczid	83	21	)	)	-RRB-
cord-253295-82ydczid	83	22	thus	thus	RB
cord-253295-82ydczid	83	23	required	require	VBN
cord-253295-82ydczid	83	24	at	at	IN
cord-253295-82ydczid	83	25	least	least	RBS
cord-253295-82ydczid	83	26	14	14	CD
cord-253295-82ydczid	83	27	centuries	century	NNS
cord-253295-82ydczid	83	28	before	before	IN
cord-253295-82ydczid	83	29	challenge	challenge	NN
cord-253295-82ydczid	83	30	,	,	,
cord-253295-82ydczid	83	31	scientific	scientific	JJ
cord-253295-82ydczid	83	32	disproof	disproof	NN
cord-253295-82ydczid	83	33	,	,	,
cord-253295-82ydczid	83	34	and	and	CC
cord-253295-82ydczid	83	35	eventual	eventual	JJ
cord-253295-82ydczid	83	36	medical	medical	JJ
cord-253295-82ydczid	83	37	community	community	NN
cord-253295-82ydczid	83	38	acceptance	acceptance	NN
cord-253295-82ydczid	83	39	.	.	.
cord-253295-82ydczid	84	1	The	the	DT
cord-253295-82ydczid	84	2	scientific	scientific	JJ
cord-253295-82ydczid	84	3	method	method	NN
cord-253295-82ydczid	84	4	facilitates	facilitate	VBZ
cord-253295-82ydczid	84	5	empirical	empirical	JJ
cord-253295-82ydczid	84	6	,	,	,
cord-253295-82ydczid	84	7	rational	rational	JJ
cord-253295-82ydczid	84	8	,	,	,
cord-253295-82ydczid	84	9	and	and	CC
cord-253295-82ydczid	84	10	skeptical	skeptical	JJ
cord-253295-82ydczid	84	11	approaches	approach	NNS
cord-253295-82ydczid	84	12	to	to	IN
cord-253295-82ydczid	84	13	observational	observational	JJ
cord-253295-82ydczid	84	14	data	datum	NNS
cord-253295-82ydczid	84	15	,	,	,
cord-253295-82ydczid	84	16	and	and	CC
cord-253295-82ydczid	84	17	minimizes	minimize	VBZ
cord-253295-82ydczid	84	18	human	human	JJ
cord-253295-82ydczid	84	19	dependence	dependence	NN
cord-253295-82ydczid	84	20	on	on	IN
cord-253295-82ydczid	84	21	non	non	JJ
cord-253295-82ydczid	84	22	-	-	JJ
cord-253295-82ydczid	84	23	evidence	evidence	NN
cord-253295-82ydczid	84	24	-	-	HYPH
cord-253295-82ydczid	84	25	based	base	VBN
cord-253295-82ydczid	84	26	traditional	traditional	JJ
cord-253295-82ydczid	84	27	models	model	NNS
cord-253295-82ydczid	84	28	.	.	.
cord-253295-82ydczid	85	1	In	in	IN
cord-253295-82ydczid	85	2	spite	spite	NN
cord-253295-82ydczid	85	3	of	of	IN
cord-253295-82ydczid	85	4	the	the	DT
cord-253295-82ydczid	85	5	scientific	scientific	JJ
cord-253295-82ydczid	85	6	method	method	NN
cord-253295-82ydczid	85	7	,	,	,
cord-253295-82ydczid	85	8	physicians	physician	NNS
cord-253295-82ydczid	85	9	are	be	VBP
cord-253295-82ydczid	85	10	still	still	RB
cord-253295-82ydczid	85	11	human	human	JJ
cord-253295-82ydczid	85	12	,	,	,
cord-253295-82ydczid	85	13	and	and	CC
cord-253295-82ydczid	85	14	the	the	DT
cord-253295-82ydczid	85	15	medical	medical	JJ
cord-253295-82ydczid	85	16	community	community	NN
cord-253295-82ydczid	85	17	still	still	RB
cord-253295-82ydczid	85	18	shows	show	VBZ
cord-253295-82ydczid	85	19	an	an	DT
cord-253295-82ydczid	85	20	inertial	inertial	JJ
cord-253295-82ydczid	85	21	reluctance	reluctance	NN
cord-253295-82ydczid	85	22	to	to	TO
cord-253295-82ydczid	85	23	adapt	adapt	VB
cord-253295-82ydczid	85	24	to	to	IN
cord-253295-82ydczid	85	25	new	new	JJ
cord-253295-82ydczid	85	26	information	information	NN
cord-253295-82ydczid	85	27	when	when	WRB
cord-253295-82ydczid	85	28	it	-PRON-	PRP
cord-253295-82ydczid	85	29	disrupts	disrupt	VBZ
cord-253295-82ydczid	85	30	traditional	traditional	JJ
cord-253295-82ydczid	85	31	paradigms	paradigm	NNS
cord-253295-82ydczid	85	32	.	.	.
cord-253295-82ydczid	86	1	Recent	recent	JJ
cord-253295-82ydczid	86	2	examples	example	NNS
cord-253295-82ydczid	86	3	would	would	MD
cord-253295-82ydczid	86	4	include	include	VB
cord-253295-82ydczid	86	5	reluctance	reluctance	NN
cord-253295-82ydczid	86	6	to	to	TO
cord-253295-82ydczid	86	7	accept	accept	VB
cord-253295-82ydczid	86	8	an	an	DT
cord-253295-82ydczid	86	9	etiologic	etiologic	JJ
cord-253295-82ydczid	86	10	role	role	NN
cord-253295-82ydczid	86	11	for	for	IN
cord-253295-82ydczid	86	12	the	the	DT
cord-253295-82ydczid	86	13	H.	H.	NNP
cord-253295-82ydczid	86	14	pylori	pylori	NN
cord-253295-82ydczid	86	15	bacterium	bacterium	NN
cord-253295-82ydczid	86	16	in	in	IN
cord-253295-82ydczid	86	17	peptic	peptic	JJ
cord-253295-82ydczid	86	18	ulcer	ulcer	NN
cord-253295-82ydczid	86	19	disease	disease	NN
cord-253295-82ydczid	86	20	,	,	,
cord-253295-82ydczid	86	21	and	and	CC
cord-253295-82ydczid	86	22	reluctance	reluctance	NN
cord-253295-82ydczid	86	23	to	to	TO
cord-253295-82ydczid	86	24	offer	offer	VB
cord-253295-82ydczid	86	25	less	less	JJR
cord-253295-82ydczid	86	26	than	than	IN
cord-253295-82ydczid	86	27	radical	radical	JJ
cord-253295-82ydczid	86	28	mastectomy	mastectomy	NN
cord-253295-82ydczid	86	29	for	for	IN
cord-253295-82ydczid	86	30	primary	primary	JJ
cord-253295-82ydczid	86	31	breast	breast	NN
cord-253295-82ydczid	86	32	carcinoma	carcinoma	NN
cord-253295-82ydczid	86	33	.	.	.
cord-253295-82ydczid	87	1	Before	before	IN
cord-253295-82ydczid	87	2	the	the	DT
cord-253295-82ydczid	87	3	use	use	NN
cord-253295-82ydczid	87	4	of	of	IN
cord-253295-82ydczid	87	5	lenses	lense	NNS
cord-253295-82ydczid	87	6	to	to	TO
cord-253295-82ydczid	87	7	magnify	magnify	VB
cord-253295-82ydczid	87	8	objects	object	NNS
cord-253295-82ydczid	87	9	,	,	,
cord-253295-82ydczid	87	10	it	-PRON-	PRP
cord-253295-82ydczid	87	11	was	be	VBD
cord-253295-82ydczid	87	12	physically	physically	RB
cord-253295-82ydczid	87	13	impossible	impossible	JJ
cord-253295-82ydczid	87	14	to	to	TO
cord-253295-82ydczid	87	15	make	make	VB
cord-253295-82ydczid	87	16	observations	observation	NNS
cord-253295-82ydczid	87	17	on	on	IN
cord-253295-82ydczid	87	18	objects	object	NNS
cord-253295-82ydczid	87	19	smaller	small	JJR
cord-253295-82ydczid	87	20	than	than	IN
cord-253295-82ydczid	87	21	the	the	DT
cord-253295-82ydczid	87	22	resolving	resolve	VBG
cord-253295-82ydczid	87	23	limit	limit	NN
cord-253295-82ydczid	87	24	of	of	IN
cord-253295-82ydczid	87	25	the	the	DT
cord-253295-82ydczid	87	26	human	human	JJ
cord-253295-82ydczid	87	27	eye	eye	NN
cord-253295-82ydczid	87	28	(	(	-LRB-
cord-253295-82ydczid	87	29	about	about	RB
cord-253295-82ydczid	87	30	0.1À0.25	0.1à0.25	CD
cord-253295-82ydczid	87	31	mm	mm	NNS
cord-253295-82ydczid	87	32	)	)	-RRB-
cord-253295-82ydczid	87	33	.	.	.
cord-253295-82ydczid	88	1	Thus	thus	RB
cord-253295-82ydczid	88	2	,	,	,
cord-253295-82ydczid	88	3	prokaryotic	prokaryotic	JJ
cord-253295-82ydczid	88	4	and	and	CC
cord-253295-82ydczid	88	5	eukaryotic	eukaryotic	JJ
cord-253295-82ydczid	88	6	cells	cell	NNS
cord-253295-82ydczid	88	7	,	,	,
cord-253295-82ydczid	88	8	tissue	tissue	NN
cord-253295-82ydczid	88	9	architecture	architecture	NN
cord-253295-82ydczid	88	10	,	,	,
cord-253295-82ydczid	88	11	and	and	CC
cord-253295-82ydczid	88	12	comparisons	comparison	NNS
cord-253295-82ydczid	88	13	of	of	IN
cord-253295-82ydczid	88	14	normal	normal	JJ
cord-253295-82ydczid	88	15	and	and	CC
cord-253295-82ydczid	88	16	disease	disease	NN
cord-253295-82ydczid	88	17	microanatomy	microanatomy	NN
cord-253295-82ydczid	88	18	were	be	VBD
cord-253295-82ydczid	88	19	philosophical	philosophical	JJ
cord-253295-82ydczid	88	20	speculation	speculation	NN
cord-253295-82ydczid	88	21	until	until	IN
cord-253295-82ydczid	88	22	description	description	NN
cord-253295-82ydczid	88	23	of	of	IN
cord-253295-82ydczid	88	24	the	the	DT
cord-253295-82ydczid	88	25	mathematics	mathematic	NNS
cord-253295-82ydczid	88	26	of	of	IN
cord-253295-82ydczid	88	27	optics	optics	NNP
cord-253295-82ydczid	88	28	and	and	CC
cord-253295-82ydczid	88	29	lens	lens	NN
cord-253295-82ydczid	88	30	design	design	NN
cord-253295-82ydczid	88	31	.	.	.
cord-253295-82ydczid	89	1	In	in	IN
cord-253295-82ydczid	89	2	a	a	DT
cord-253295-82ydczid	89	3	real	real	JJ
cord-253295-82ydczid	89	4	sense	sense	NN
cord-253295-82ydczid	89	5	,	,	,
cord-253295-82ydczid	89	6	optical	optical	JJ
cord-253295-82ydczid	89	7	technology	technology	NN
cord-253295-82ydczid	89	8	was	be	VBD
cord-253295-82ydczid	89	9	rate	rate	NN
cord-253295-82ydczid	89	10	-	-	HYPH
cord-253295-82ydczid	89	11	limiting	limit	VBG
cord-253295-82ydczid	89	12	for	for	IN
cord-253295-82ydczid	89	13	the	the	DT
cord-253295-82ydczid	89	14	development	development	NN
cord-253295-82ydczid	89	15	of	of	IN
cord-253295-82ydczid	89	16	the	the	DT
cord-253295-82ydczid	89	17	fields	field	NNS
cord-253295-82ydczid	89	18	of	of	IN
cord-253295-82ydczid	89	19	tissue	tissue	NN
cord-253295-82ydczid	89	20	anatomy	anatomy	NN
cord-253295-82ydczid	89	21	,	,	,
cord-253295-82ydczid	89	22	cellular	cellular	JJ
cord-253295-82ydczid	89	23	biology	biology	NN
cord-253295-82ydczid	89	24	,	,	,
cord-253295-82ydczid	89	25	and	and	CC
cord-253295-82ydczid	89	26	microbiology	microbiology	NN
cord-253295-82ydczid	89	27	.	.	.
cord-253295-82ydczid	90	1	Concepts	concept	NNS
cord-253295-82ydczid	90	2	of	of	IN
cord-253295-82ydczid	90	3	optics	optic	NNS
cord-253295-82ydczid	90	4	were	be	VBD
cord-253295-82ydczid	90	5	written	write	VBN
cord-253295-82ydczid	90	6	as	as	RB
cord-253295-82ydczid	90	7	early	early	RB
cord-253295-82ydczid	90	8	as	as	IN
cord-253295-82ydczid	90	9	300	300	CD
cord-253295-82ydczid	90	10	BCE	BCE	NNP
cord-253295-82ydczid	90	11	in	in	IN
cord-253295-82ydczid	90	12	Alexandria	Alexandria	NNP
cord-253295-82ydczid	90	13	(	(	-LRB-
cord-253295-82ydczid	90	14	Optica	Optica	NNP
cord-253295-82ydczid	90	15	,	,	,
cord-253295-82ydczid	90	16	Euclid	Euclid	NNP
cord-253295-82ydczid	90	17	)	)	-RRB-
cord-253295-82ydczid	90	18	.	.	.
cord-253295-82ydczid	91	1	Clear	clear	JJ
cord-253295-82ydczid	91	2	glass	glass	NN
cord-253295-82ydczid	91	3	(	(	-LRB-
cord-253295-82ydczid	91	4	crystallo	crystallo	NNP
cord-253295-82ydczid	91	5	)	)	-RRB-
cord-253295-82ydczid	91	6	was	be	VBD
cord-253295-82ydczid	91	7	developed	develop	VBN
cord-253295-82ydczid	91	8	in	in	IN
cord-253295-82ydczid	91	9	Venice	Venice	NNP
cord-253295-82ydczid	91	10	in	in	IN
cord-253295-82ydczid	91	11	the	the	DT
cord-253295-82ydczid	91	12	15th	15th	JJ
cord-253295-82ydczid	91	13	century	century	NN
cord-253295-82ydczid	91	14	.	.	.
cord-253295-82ydczid	92	1	A	a	DT
cord-253295-82ydczid	92	2	compound	compound	NN
cord-253295-82ydczid	92	3	microscope	microscope	NN
cord-253295-82ydczid	92	4	was	be	VBD
cord-253295-82ydczid	92	5	invented	invent	VBN
cord-253295-82ydczid	92	6	by	by	IN
cord-253295-82ydczid	92	7	Janssen	Janssen	NNP
cord-253295-82ydczid	92	8	in	in	IN
cord-253295-82ydczid	92	9	1590	1590	CD
cord-253295-82ydczid	92	10	CE	CE	NNP
cord-253295-82ydczid	92	11	.	.	.
cord-253295-82ydczid	93	1	Microanatomy	microanatomy	NN
cord-253295-82ydczid	93	2	and	and	CC
cord-253295-82ydczid	93	3	structural	structural	JJ
cord-253295-82ydczid	93	4	terminology	terminology	NN
cord-253295-82ydczid	93	5	was	be	VBD
cord-253295-82ydczid	93	6	begun	begin	VBN
cord-253295-82ydczid	93	7	by	by	IN
cord-253295-82ydczid	93	8	Malpighi	Malpighi	NNP
cord-253295-82ydczid	93	9	(	(	-LRB-
cord-253295-82ydczid	93	10	1661	1661	CD
cord-253295-82ydczid	93	11	CE	CE	NNP
cord-253295-82ydczid	93	12	)	)	-RRB-
cord-253295-82ydczid	93	13	,	,	,
cord-253295-82ydczid	93	14	who	who	WP
cord-253295-82ydczid	93	15	examined	examine	VBD
cord-253295-82ydczid	93	16	capillaries	capillary	NNS
cord-253295-82ydczid	93	17	in	in	IN
cord-253295-82ydczid	93	18	frog	frog	NN
cord-253295-82ydczid	93	19	lung	lung	NN
cord-253295-82ydczid	93	20	,	,	,
cord-253295-82ydczid	93	21	trachea	trachea	NN
cord-253295-82ydczid	93	22	tubes	tube	NNS
cord-253295-82ydczid	93	23	for	for	IN
cord-253295-82ydczid	93	24	airflow	airflow	NN
cord-253295-82ydczid	93	25	in	in	IN
cord-253295-82ydczid	93	26	silkworms	silkworm	NNS
cord-253295-82ydczid	93	27	,	,	,
cord-253295-82ydczid	93	28	and	and	CC
cord-253295-82ydczid	93	29	stomata	stoma	NNS
cord-253295-82ydczid	93	30	in	in	IN
cord-253295-82ydczid	93	31	plant	plant	NN
cord-253295-82ydczid	93	32	leaves	leave	NNS
cord-253295-82ydczid	93	33	.	.	.
cord-253295-82ydczid	94	1	Robert	Robert	NNP
cord-253295-82ydczid	94	2	Hooke	Hooke	NNP
cord-253295-82ydczid	94	3	used	use	VBD
cord-253295-82ydczid	94	4	a	a	DT
cord-253295-82ydczid	94	5	compound	compound	NN
cord-253295-82ydczid	94	6	microscope	microscope	NN
cord-253295-82ydczid	94	7	to	to	TO
cord-253295-82ydczid	94	8	describe	describe	VB
cord-253295-82ydczid	94	9	common	common	JJ
cord-253295-82ydczid	94	10	objects	object	NNS
cord-253295-82ydczid	94	11	in	in	IN
cord-253295-82ydczid	94	12	Micrographia	Micrographia	NNP
cord-253295-82ydczid	94	13	(	(	-LRB-
cord-253295-82ydczid	94	14	1665	1665	CD
cord-253295-82ydczid	94	15	CE	CE	NNP
cord-253295-82ydczid	94	16	)	)	-RRB-
cord-253295-82ydczid	94	17	.	.	.
cord-253295-82ydczid	95	1	Antony	Antony	NNP
cord-253295-82ydczid	95	2	Van	Van	NNP
cord-253295-82ydczid	95	3	Leeuwenhoek	Leeuwenhoek	NNP
cord-253295-82ydczid	95	4	used	use	VBD
cord-253295-82ydczid	95	5	self	self	NN
cord-253295-82ydczid	95	6	-	-	HYPH
cord-253295-82ydczid	95	7	made	make	VBN
cord-253295-82ydczid	95	8	simple	simple	JJ
cord-253295-82ydczid	95	9	magnifying	magnifying	NN
cord-253295-82ydczid	95	10	lenses	lense	NNS
cord-253295-82ydczid	95	11	to	to	TO
cord-253295-82ydczid	95	12	count	count	VB
cord-253295-82ydczid	95	13	the	the	DT
cord-253295-82ydczid	95	14	threads	thread	NNS
cord-253295-82ydczid	95	15	in	in	IN
cord-253295-82ydczid	95	16	cloth	cloth	NN
cord-253295-82ydczid	95	17	in	in	IN
cord-253295-82ydczid	95	18	a	a	DT
cord-253295-82ydczid	95	19	Dutch	dutch	JJ
cord-253295-82ydczid	95	20	dry	dry	JJ
cord-253295-82ydczid	95	21	-	-	HYPH
cord-253295-82ydczid	95	22	goods	good	NNS
cord-253295-82ydczid	95	23	store	store	NN
cord-253295-82ydczid	95	24	,	,	,
cord-253295-82ydczid	95	25	then	then	RB
cord-253295-82ydczid	95	26	later	later	RB
cord-253295-82ydczid	95	27	published	publish	VBN
cord-253295-82ydczid	95	28	descriptions	description	NNS
cord-253295-82ydczid	95	29	of	of	IN
cord-253295-82ydczid	95	30	bacteria	bacteria	NNS
cord-253295-82ydczid	95	31	(	(	-LRB-
cord-253295-82ydczid	95	32	termed	term	VBN
cord-253295-82ydczid	95	33	animalcules	animalcule	NNS
cord-253295-82ydczid	95	34	)	)	-RRB-
cord-253295-82ydczid	95	35	,	,	,
cord-253295-82ydczid	95	36	yeast	yeast	NN
cord-253295-82ydczid	95	37	,	,	,
cord-253295-82ydczid	95	38	and	and	CC
cord-253295-82ydczid	95	39	algae	algae	NN
cord-253295-82ydczid	95	40	,	,	,
cord-253295-82ydczid	95	41	beginning	begin	VBG
cord-253295-82ydczid	95	42	in	in	IN
cord-253295-82ydczid	95	43	1673	1673	CD
cord-253295-82ydczid	95	44	CE	CE	NNP
cord-253295-82ydczid	95	45	.	.	.
cord-253295-82ydczid	96	1	Yet	yet	RB
cord-253295-82ydczid	96	2	the	the	DT
cord-253295-82ydczid	96	3	relevance	relevance	NN
cord-253295-82ydczid	96	4	of	of	IN
cord-253295-82ydczid	96	5	these	these	DT
cord-253295-82ydczid	96	6	observations	observation	NNS
cord-253295-82ydczid	96	7	in	in	IN
cord-253295-82ydczid	96	8	microanatomy	microanatomy	NN
cord-253295-82ydczid	96	9	and	and	CC
cord-253295-82ydczid	96	10	microbiology	microbiology	NN
cord-253295-82ydczid	96	11	to	to	IN
cord-253295-82ydczid	96	12	human	human	JJ
cord-253295-82ydczid	96	13	diseases	disease	NNS
cord-253295-82ydczid	96	14	required	require	VBD
cord-253295-82ydczid	96	15	changes	change	NNS
cord-253295-82ydczid	96	16	in	in	IN
cord-253295-82ydczid	96	17	conceptual	conceptual	JJ
cord-253295-82ydczid	96	18	understanding	understanding	NN
cord-253295-82ydczid	96	19	of	of	IN
cord-253295-82ydczid	96	20	the	the	DT
cord-253295-82ydczid	96	21	etiology	etiology	NN
cord-253295-82ydczid	96	22	and	and	CC
cord-253295-82ydczid	96	23	pathogenesis	pathogenesis	NN
cord-253295-82ydczid	96	24	of	of	IN
cord-253295-82ydczid	96	25	diseases	disease	NNS
cord-253295-82ydczid	96	26	.	.	.
cord-253295-82ydczid	97	1	For	for	IN
cord-253295-82ydczid	97	2	example	example	NN
cord-253295-82ydczid	97	3	,	,	,
cord-253295-82ydczid	97	4	it	-PRON-	PRP
cord-253295-82ydczid	97	5	was	be	VBD
cord-253295-82ydczid	97	6	200	200	CD
cord-253295-82ydczid	97	7	years	year	NNS
cord-253295-82ydczid	97	8	after	after	IN
cord-253295-82ydczid	97	9	Van	Van	NNP
cord-253295-82ydczid	97	10	Leeuwenhoek	Leeuwenhoek	NNP
cord-253295-82ydczid	97	11	that	that	IN
cord-253295-82ydczid	97	12	a	a	DT
cord-253295-82ydczid	97	13	Streptococcus	Streptococcus	NNP
cord-253295-82ydczid	97	14	sp	sp	NN
cord-253295-82ydczid	97	15	.	.	.
cord-253295-82ydczid	97	16	was	be	VBD
cord-253295-82ydczid	97	17	recognized	recognize	VBN
cord-253295-82ydczid	97	18	by	by	IN
cord-253295-82ydczid	97	19	Koch	Koch	NNP
cord-253295-82ydczid	97	20	and	and	CC
cord-253295-82ydczid	97	21	Pasteur	Pasteur	NNP
cord-253295-82ydczid	97	22	as	as	IN
cord-253295-82ydczid	97	23	the	the	DT
cord-253295-82ydczid	97	24	likely	likely	JJ
cord-253295-82ydczid	97	25	etiologic	etiologic	JJ
cord-253295-82ydczid	97	26	agent	agent	NN
cord-253295-82ydczid	97	27	of	of	IN
cord-253295-82ydczid	97	28	puerperal	puerperal	JJ
cord-253295-82ydczid	97	29	fever	fever	NN
cord-253295-82ydczid	97	30	in	in	IN
cord-253295-82ydczid	97	31	post	post	JJ
cord-253295-82ydczid	97	32	-	-	JJ
cord-253295-82ydczid	97	33	partum	partum	JJ
cord-253295-82ydczid	97	34	women	woman	NNS
cord-253295-82ydczid	97	35	.	.	.
cord-253295-82ydczid	98	1	The	the	DT
cord-253295-82ydczid	98	2	relevance	relevance	NN
cord-253295-82ydczid	98	3	of	of	IN
cord-253295-82ydczid	98	4	microanatomy	microanatomy	NN
cord-253295-82ydczid	98	5	and	and	CC
cord-253295-82ydczid	98	6	microbiology	microbiology	NN
cord-253295-82ydczid	98	7	to	to	IN
cord-253295-82ydczid	98	8	human	human	JJ
cord-253295-82ydczid	98	9	disease	disease	NN
cord-253295-82ydczid	98	10	required	require	VBN
cord-253295-82ydczid	98	11	expansion	expansion	NN
cord-253295-82ydczid	98	12	of	of	IN
cord-253295-82ydczid	98	13	conceptual	conceptual	JJ
cord-253295-82ydczid	98	14	understanding	understanding	NN
cord-253295-82ydczid	98	15	to	to	TO
cord-253295-82ydczid	98	16	include	include	VB
cord-253295-82ydczid	98	17	morphologic	morphologic	JJ
cord-253295-82ydczid	98	18	changes	change	NNS
cord-253295-82ydczid	98	19	in	in	IN
cord-253295-82ydczid	98	20	diseased	diseased	JJ
cord-253295-82ydczid	98	21	cells	cell	NNS
cord-253295-82ydczid	98	22	and	and	CC
cord-253295-82ydczid	98	23	tissues	tissue	NNS
cord-253295-82ydczid	98	24	,	,	,
cord-253295-82ydczid	98	25	as	as	RB
cord-253295-82ydczid	98	26	well	well	RB
cord-253295-82ydczid	98	27	as	as	IN
cord-253295-82ydczid	98	28	recognition	recognition	NN
cord-253295-82ydczid	98	29	of	of	IN
cord-253295-82ydczid	98	30	an	an	DT
cord-253295-82ydczid	98	31	etiologic	etiologic	JJ
cord-253295-82ydczid	98	32	role	role	NN
cord-253295-82ydczid	98	33	for	for	IN
cord-253295-82ydczid	98	34	microorganisms	microorganism	NNS
cord-253295-82ydczid	98	35	.	.	.
cord-253295-82ydczid	99	1	Rokitansky	Rokitansky	NNP
cord-253295-82ydczid	99	2	's	's	POS
cord-253295-82ydczid	99	3	gross	gross	JJ
cord-253295-82ydczid	99	4	correlates	correlate	NNS
cord-253295-82ydczid	99	5	with	with	IN
cord-253295-82ydczid	99	6	clinical	clinical	JJ
cord-253295-82ydczid	99	7	disease	disease	NN
cord-253295-82ydczid	99	8	(	(	-LRB-
cord-253295-82ydczid	99	9	A	a	DT
cord-253295-82ydczid	99	10	Manual	Manual	NNP
cord-253295-82ydczid	99	11	of	of	IN
cord-253295-82ydczid	99	12	Pathological	Pathological	NNP
cord-253295-82ydczid	99	13	Anatomy	Anatomy	NNP
cord-253295-82ydczid	99	14	,	,	,
cord-253295-82ydczid	99	15	1846	1846	CD
cord-253295-82ydczid	99	16	)	)	-RRB-
cord-253295-82ydczid	99	17	,	,	,
cord-253295-82ydczid	99	18	Paget	Paget	NNP
cord-253295-82ydczid	99	19	's	's	POS
cord-253295-82ydczid	99	20	surgical	surgical	JJ
cord-253295-82ydczid	99	21	perspective	perspective	NN
cord-253295-82ydczid	99	22	on	on	IN
cord-253295-82ydczid	99	23	gross	gross	JJ
cord-253295-82ydczid	99	24	pathology	pathology	NN
cord-253295-82ydczid	99	25	,	,	,
cord-253295-82ydczid	99	26	and	and	CC
cord-253295-82ydczid	99	27	Virchow	Virchow	NNP
cord-253295-82ydczid	99	28	's	's	POS
cord-253295-82ydczid	99	29	morphologic	morphologic	JJ
cord-253295-82ydczid	99	30	correlates	correlate	NNS
cord-253295-82ydczid	99	31	with	with	IN
cord-253295-82ydczid	99	32	clinical	clinical	JJ
cord-253295-82ydczid	99	33	disease	disease	NN
cord-253295-82ydczid	99	34	were	be	VBD
cord-253295-82ydczid	99	35	critical	critical	JJ
cord-253295-82ydczid	99	36	to	to	IN
cord-253295-82ydczid	99	37	the	the	DT
cord-253295-82ydczid	99	38	development	development	NN
cord-253295-82ydczid	99	39	of	of	IN
cord-253295-82ydczid	99	40	clinico	clinico	NN
cord-253295-82ydczid	99	41	-	-	HYPH
cord-253295-82ydczid	99	42	pathologic	pathologic	JJ
cord-253295-82ydczid	99	43	correlation	correlation	NN
cord-253295-82ydczid	99	44	,	,	,
cord-253295-82ydczid	99	45	and	and	CC
cord-253295-82ydczid	99	46	served	serve	VBD
cord-253295-82ydczid	99	47	to	to	TO
cord-253295-82ydczid	99	48	create	create	VB
cord-253295-82ydczid	99	49	a	a	DT
cord-253295-82ydczid	99	50	role	role	NN
cord-253295-82ydczid	99	51	for	for	IN
cord-253295-82ydczid	99	52	pathologists	pathologist	NNS
cord-253295-82ydczid	99	53	to	to	TO
cord-253295-82ydczid	99	54	specialize	specialize	VB
cord-253295-82ydczid	99	55	in	in	IN
cord-253295-82ydczid	99	56	autopsy	autopsy	JJ
cord-253295-82ydczid	99	57	and	and	CC
cord-253295-82ydczid	99	58	tissue	tissue	NN
cord-253295-82ydczid	99	59	diagnosis	diagnosis	NN
cord-253295-82ydczid	99	60	.	.	.
cord-253295-82ydczid	100	1	Virchow	Virchow	NNP
cord-253295-82ydczid	100	2	's	's	POS
cord-253295-82ydczid	100	3	description	description	NN
cord-253295-82ydczid	100	4	of	of	IN
cord-253295-82ydczid	100	5	necrotizing	necrotize	VBG
cord-253295-82ydczid	100	6	granulomatous	granulomatous	JJ
cord-253295-82ydczid	100	7	inflammation	inflammation	NN
cord-253295-82ydczid	100	8	,	,	,
cord-253295-82ydczid	100	9	the	the	DT
cord-253295-82ydczid	100	10	morphologic	morphologic	JJ
cord-253295-82ydczid	100	11	correlate	correlate	NN
cord-253295-82ydczid	100	12	of	of	IN
cord-253295-82ydczid	100	13	infections	infection	NNS
cord-253295-82ydczid	100	14	caused	cause	VBN
cord-253295-82ydczid	100	15	by	by	IN
cord-253295-82ydczid	100	16	mycobacteria	mycobacterium	NNS
cord-253295-82ydczid	100	17	such	such	JJ
cord-253295-82ydczid	100	18	as	as	IN
cord-253295-82ydczid	100	19	TB	TB	NNP
cord-253295-82ydczid	100	20	and	and	CC
cord-253295-82ydczid	100	21	leprosy	leprosy	NN
cord-253295-82ydczid	100	22	,	,	,
cord-253295-82ydczid	100	23	preceded	precede	VBD
cord-253295-82ydczid	100	24	the	the	DT
cord-253295-82ydczid	100	25	discovery	discovery	NN
cord-253295-82ydczid	100	26	of	of	IN
cord-253295-82ydczid	100	27	the	the	DT
cord-253295-82ydczid	100	28	etiologic	etiologic	JJ
cord-253295-82ydczid	100	29	agents	agent	NNS
cord-253295-82ydczid	100	30	years	year	NNS
cord-253295-82ydczid	100	31	later	later	RB
cord-253295-82ydczid	100	32	by	by	IN
cord-253295-82ydczid	100	33	Hansen	Hansen	NNP
cord-253295-82ydczid	100	34	(	(	-LRB-
cord-253295-82ydczid	100	35	M.	M.	NNP
cord-253295-82ydczid	100	36	leprae	leprae	NNP
cord-253295-82ydczid	100	37	,	,	,
cord-253295-82ydczid	100	38	1873	1873	CD
cord-253295-82ydczid	100	39	)	)	-RRB-
cord-253295-82ydczid	100	40	and	and	CC
cord-253295-82ydczid	100	41	Koch	Koch	NNP
cord-253295-82ydczid	100	42	(	(	-LRB-
cord-253295-82ydczid	100	43	M.	M.	NNP
cord-253295-82ydczid	100	44	tuberculosis	tuberculosis	NN
cord-253295-82ydczid	100	45	,	,	,
cord-253295-82ydczid	100	46	1882	1882	CD
cord-253295-82ydczid	100	47	)	)	-RRB-
cord-253295-82ydczid	100	48	.	.	.
cord-253295-82ydczid	101	1	The	the	DT
cord-253295-82ydczid	101	2	causal	causal	JJ
cord-253295-82ydczid	101	3	relationship	relationship	NN
cord-253295-82ydczid	101	4	between	between	IN
cord-253295-82ydczid	101	5	microorganisms	microorganism	NNS
cord-253295-82ydczid	101	6	and	and	CC
cord-253295-82ydczid	101	7	clinical	clinical	JJ
cord-253295-82ydczid	101	8	disease	disease	NN
cord-253295-82ydczid	101	9	required	require	VBD
cord-253295-82ydczid	101	10	scientific	scientific	JJ
cord-253295-82ydczid	101	11	demonstration	demonstration	NN
cord-253295-82ydczid	101	12	and	and	CC
cord-253295-82ydczid	101	13	logical	logical	JJ
cord-253295-82ydczid	101	14	proof	proof	NN
cord-253295-82ydczid	101	15	before	before	IN
cord-253295-82ydczid	101	16	medical	medical	JJ
cord-253295-82ydczid	101	17	community	community	NN
cord-253295-82ydczid	101	18	acceptance	acceptance	NN
cord-253295-82ydczid	101	19	.	.	.
cord-253295-82ydczid	102	1	For	for	IN
cord-253295-82ydczid	102	2	example	example	NN
cord-253295-82ydczid	102	3	,	,	,
cord-253295-82ydczid	102	4	identification	identification	NN
cord-253295-82ydczid	102	5	of	of	IN
cord-253295-82ydczid	102	6	the	the	DT
cord-253295-82ydczid	102	7	cause	cause	NN
cord-253295-82ydczid	102	8	-	-	HYPH
cord-253295-82ydczid	102	9	and	and	CC
cord-253295-82ydczid	102	10	-	-	HYPH
cord-253295-82ydczid	102	11	effect	effect	NN
cord-253295-82ydczid	102	12	relationship	relationship	NN
cord-253295-82ydczid	102	13	between	between	IN
cord-253295-82ydczid	102	14	Streptococcus	Streptococcus	NNP
cord-253295-82ydczid	102	15	sp	sp	NN
cord-253295-82ydczid	102	16	.	.	.
cord-253295-82ydczid	102	17	and	and	CC
cord-253295-82ydczid	102	18	puerperal	puerperal	JJ
cord-253295-82ydczid	102	19	fever	fever	NN
cord-253295-82ydczid	102	20	required	require	VBD
cord-253295-82ydczid	102	21	an	an	DT
cord-253295-82ydczid	102	22	initial	initial	JJ
cord-253295-82ydczid	102	23	recognition	recognition	NN
cord-253295-82ydczid	102	24	of	of	IN
cord-253295-82ydczid	102	25	unusual	unusual	JJ
cord-253295-82ydczid	102	26	clinical	clinical	JJ
cord-253295-82ydczid	102	27	outcomes	outcome	NNS
cord-253295-82ydczid	102	28	(	(	-LRB-
cord-253295-82ydczid	102	29	clusters	cluster	NNS
cord-253295-82ydczid	102	30	of	of	IN
cord-253295-82ydczid	102	31	postpartum	postpartum	NN
cord-253295-82ydczid	102	32	deaths	death	NNS
cord-253295-82ydczid	102	33	)	)	-RRB-
cord-253295-82ydczid	102	34	,	,	,
cord-253295-82ydczid	102	35	then	then	RB
cord-253295-82ydczid	102	36	correlation	correlation	NN
cord-253295-82ydczid	102	37	of	of	IN
cord-253295-82ydczid	102	38	puerperal	puerperal	JJ
cord-253295-82ydczid	102	39	fever	fever	NN
cord-253295-82ydczid	102	40	clusters	cluster	NNS
cord-253295-82ydczid	102	41	with	with	IN
cord-253295-82ydczid	102	42	obstetrician	obstetrician	JJ
cord-253295-82ydczid	102	43	habits	habit	NNS
cord-253295-82ydczid	102	44	,	,	,
cord-253295-82ydczid	102	45	then	then	RB
cord-253295-82ydczid	102	46	Semmelweiss	Semmelweiss	NNP
cord-253295-82ydczid	102	47	's	's	POS
cord-253295-82ydczid	102	48	experimental	experimental	JJ
cord-253295-82ydczid	102	49	demonstration	demonstration	NN
cord-253295-82ydczid	102	50	in	in	IN
cord-253295-82ydczid	102	51	1847	1847	CD
cord-253295-82ydczid	102	52	that	that	IN
cord-253295-82ydczid	102	53	hand	hand	NN
cord-253295-82ydczid	102	54	-	-	HYPH
cord-253295-82ydczid	102	55	washing	washing	NN
cord-253295-82ydczid	102	56	reduced	reduce	VBD
cord-253295-82ydczid	102	57	the	the	DT
cord-253295-82ydczid	102	58	incidence	incidence	NN
cord-253295-82ydczid	102	59	of	of	IN
cord-253295-82ydczid	102	60	puerperal	puerperal	JJ
cord-253295-82ydczid	102	61	fever	fever	NN
cord-253295-82ydczid	102	62	,	,	,
cord-253295-82ydczid	102	63	then	then	RB
cord-253295-82ydczid	102	64	the	the	DT
cord-253295-82ydczid	102	65	demonstration	demonstration	NN
cord-253295-82ydczid	102	66	that	that	WDT
cord-253295-82ydczid	102	67	particular	particular	JJ
cord-253295-82ydczid	102	68	bacteria	bacteria	NNS
cord-253295-82ydczid	102	69	(	(	-LRB-
cord-253295-82ydczid	102	70	Streptococci	Streptococci	NNP
cord-253295-82ydczid	102	71	)	)	-RRB-
cord-253295-82ydczid	102	72	are	be	VBP
cord-253295-82ydczid	102	73	regularly	regularly	RB
cord-253295-82ydczid	102	74	associated	associate	VBN
cord-253295-82ydczid	102	75	with	with	IN
cord-253295-82ydczid	102	76	the	the	DT
cord-253295-82ydczid	102	77	clinical	clinical	JJ
cord-253295-82ydczid	102	78	disease	disease	NN
cord-253295-82ydczid	102	79	(	(	-LRB-
cord-253295-82ydczid	102	80	Koch	Koch	NNP
cord-253295-82ydczid	102	81	,	,	,
cord-253295-82ydczid	102	82	circa	circa	NN
cord-253295-82ydczid	102	83	1870	1870	CD
cord-253295-82ydczid	102	84	)	)	-RRB-
cord-253295-82ydczid	102	85	,	,	,
cord-253295-82ydczid	102	86	and	and	CC
cord-253295-82ydczid	102	87	finally	finally	RB
cord-253295-82ydczid	102	88	by	by	IN
cord-253295-82ydczid	102	89	culture	culture	NN
cord-253295-82ydczid	102	90	of	of	IN
cord-253295-82ydczid	102	91	the	the	DT
cord-253295-82ydczid	102	92	organism	organism	NN
cord-253295-82ydczid	102	93	from	from	IN
cord-253295-82ydczid	102	94	the	the	DT
cord-253295-82ydczid	102	95	blood	blood	NN
cord-253295-82ydczid	102	96	of	of	IN
cord-253295-82ydczid	102	97	patients	patient	NNS
cord-253295-82ydczid	102	98	with	with	IN
cord-253295-82ydczid	102	99	the	the	DT
cord-253295-82ydczid	102	100	disease	disease	NN
cord-253295-82ydczid	102	101	(	(	-LRB-
cord-253295-82ydczid	102	102	Pasteur	Pasteur	NNP
cord-253295-82ydczid	102	103	,	,	,
cord-253295-82ydczid	102	104	1879	1879	CD
cord-253295-82ydczid	102	105	)	)	-RRB-
cord-253295-82ydczid	102	106	.	.	.
cord-253295-82ydczid	102	107	'	'	''
cord-253295-82ydczid	103	1	Germ	germ	NN
cord-253295-82ydczid	103	2	theory	theory	NN
cord-253295-82ydczid	103	3	'	'	''
cord-253295-82ydczid	103	4	articulates	articulate	VBZ
cord-253295-82ydczid	103	5	this	this	DT
cord-253295-82ydczid	103	6	causal	causal	JJ
cord-253295-82ydczid	103	7	relationship	relationship	NN
cord-253295-82ydczid	103	8	between	between	IN
cord-253295-82ydczid	103	9	microorganisms	microorganism	NNS
cord-253295-82ydczid	103	10	and	and	CC
cord-253295-82ydczid	103	11	clinical	clinical	JJ
cord-253295-82ydczid	103	12	diseases	disease	NNS
cord-253295-82ydczid	103	13	in	in	IN
cord-253295-82ydczid	103	14	animals	animal	NNS
cord-253295-82ydczid	103	15	and	and	CC
cord-253295-82ydczid	103	16	humans	human	NNS
cord-253295-82ydczid	103	17	.	.	.
cord-253295-82ydczid	104	1	Technical	technical	JJ
cord-253295-82ydczid	104	2	improvements	improvement	NNS
cord-253295-82ydczid	104	3	in	in	IN
cord-253295-82ydczid	104	4	microscopes	microscope	NNS
cord-253295-82ydczid	104	5	(	(	-LRB-
cord-253295-82ydczid	104	6	Abbe	Abbe	NNP
cord-253295-82ydczid	104	7	condenser	condenser	NN
cord-253295-82ydczid	104	8	,	,	,
cord-253295-82ydczid	104	9	apochromatic	apochromatic	JJ
cord-253295-82ydczid	104	10	lenses	lense	NNS
cord-253295-82ydczid	104	11	,	,	,
cord-253295-82ydczid	104	12	oil	oil	NN
cord-253295-82ydczid	104	13	immersion	immersion	NN
cord-253295-82ydczid	104	14	lenses	lense	NNS
cord-253295-82ydczid	104	15	)	)	-RRB-
cord-253295-82ydczid	104	16	,	,	,
cord-253295-82ydczid	104	17	the	the	DT
cord-253295-82ydczid	104	18	development	development	NN
cord-253295-82ydczid	104	19	of	of	IN
cord-253295-82ydczid	104	20	culture	culture	NN
cord-253295-82ydczid	104	21	media	medium	NNS
cord-253295-82ydczid	104	22	,	,	,
cord-253295-82ydczid	104	23	and	and	CC
cord-253295-82ydczid	104	24	the	the	DT
cord-253295-82ydczid	104	25	development	development	NN
cord-253295-82ydczid	104	26	of	of	IN
cord-253295-82ydczid	104	27	histochemical	histochemical	JJ
cord-253295-82ydczid	104	28	stains	stain	NNS
cord-253295-82ydczid	104	29	no	no	DT
cord-253295-82ydczid	104	30	doubt	doubt	RB
cord-253295-82ydczid	104	31	made	make	VBD
cord-253295-82ydczid	104	32	it	-PRON-	PRP
cord-253295-82ydczid	104	33	possible	possible	JJ
cord-253295-82ydczid	104	34	for	for	IN
cord-253295-82ydczid	104	35	Koch	Koch	NNP
cord-253295-82ydczid	104	36	to	to	TO
cord-253295-82ydczid	104	37	identify	identify	VB
cord-253295-82ydczid	104	38	M.	M.	NNP
cord-253295-82ydczid	104	39	tuberculosis	tuberculosis	NN
cord-253295-82ydczid	104	40	in	in	IN
cord-253295-82ydczid	104	41	1882	1882	CD
cord-253295-82ydczid	104	42	.	.	.
cord-253295-82ydczid	105	1	To	to	TO
cord-253295-82ydczid	105	2	be	be	VB
cord-253295-82ydczid	105	3	emphasized	emphasize	VBN
cord-253295-82ydczid	105	4	is	be	VBZ
cord-253295-82ydczid	105	5	the	the	DT
cord-253295-82ydczid	105	6	process	process	NN
cord-253295-82ydczid	105	7	of	of	IN
cord-253295-82ydczid	105	8	recognition	recognition	NN
cord-253295-82ydczid	105	9	,	,	,
cord-253295-82ydczid	105	10	first	first	RB
cord-253295-82ydczid	105	11	of	of	IN
cord-253295-82ydczid	105	12	all	all	DT
cord-253295-82ydczid	105	13	of	of	IN
cord-253295-82ydczid	105	14	the	the	DT
cord-253295-82ydczid	105	15	variables	variable	NNS
cord-253295-82ydczid	105	16	associated	associate	VBN
cord-253295-82ydczid	105	17	with	with	IN
cord-253295-82ydczid	105	18	the	the	DT
cord-253295-82ydczid	105	19	clinical	clinical	JJ
cord-253295-82ydczid	105	20	disease	disease	NN
cord-253295-82ydczid	105	21	,	,	,
cord-253295-82ydczid	105	22	then	then	RB
cord-253295-82ydczid	105	23	the	the	DT
cord-253295-82ydczid	105	24	scientific	scientific	JJ
cord-253295-82ydczid	105	25	demonstration	demonstration	NN
cord-253295-82ydczid	105	26	of	of	IN
cord-253295-82ydczid	105	27	a	a	DT
cord-253295-82ydczid	105	28	causal	causal	JJ
cord-253295-82ydczid	105	29	relationship	relationship	NN
cord-253295-82ydczid	105	30	between	between	IN
cord-253295-82ydczid	105	31	one	one	CD
cord-253295-82ydczid	105	32	or	or	CC
cord-253295-82ydczid	105	33	more	more	JJR
cord-253295-82ydczid	105	34	of	of	IN
cord-253295-82ydczid	105	35	these	these	DT
cord-253295-82ydczid	105	36	variables	variable	NNS
cord-253295-82ydczid	105	37	with	with	IN
cord-253295-82ydczid	105	38	the	the	DT
cord-253295-82ydczid	105	39	clinical	clinical	JJ
cord-253295-82ydczid	105	40	disease	disease	NN
cord-253295-82ydczid	105	41	.	.	.
cord-253295-82ydczid	106	1	This	this	DT
cord-253295-82ydczid	106	2	latter	latter	JJ
cord-253295-82ydczid	106	3	step	step	NN
cord-253295-82ydczid	106	4	was	be	VBD
cord-253295-82ydczid	106	5	enunciated	enunciate	VBN
cord-253295-82ydczid	106	6	as	as	IN
cord-253295-82ydczid	106	7	Koch	Koch	NNP
cord-253295-82ydczid	106	8	's	's	POS
cord-253295-82ydczid	106	9	postulates	postulate	NNS
cord-253295-82ydczid	106	10	(	(	-LRB-
cord-253295-82ydczid	106	11	1890	1890	CD
cord-253295-82ydczid	106	12	)	)	-RRB-
cord-253295-82ydczid	106	13	:	:	:
cord-253295-82ydczid	106	14	(	(	-LRB-
cord-253295-82ydczid	106	15	i	i	NN
cord-253295-82ydczid	106	16	)	)	-RRB-
cord-253295-82ydczid	107	1	the	the	DT
cord-253295-82ydczid	107	2	bacteria	bacteria	NNS
cord-253295-82ydczid	107	3	must	must	MD
cord-253295-82ydczid	107	4	be	be	VB
cord-253295-82ydczid	107	5	present	present	JJ
cord-253295-82ydczid	107	6	in	in	IN
cord-253295-82ydczid	107	7	every	every	DT
cord-253295-82ydczid	107	8	case	case	NN
cord-253295-82ydczid	107	9	of	of	IN
cord-253295-82ydczid	107	10	the	the	DT
cord-253295-82ydczid	107	11	disease	disease	NN
cord-253295-82ydczid	107	12	,	,	,
cord-253295-82ydczid	107	13	(	(	-LRB-
cord-253295-82ydczid	107	14	ii	ii	NN
cord-253295-82ydczid	107	15	)	)	-RRB-
cord-253295-82ydczid	108	1	the	the	DT
cord-253295-82ydczid	108	2	bacteria	bacteria	NNS
cord-253295-82ydczid	108	3	must	must	MD
cord-253295-82ydczid	108	4	be	be	VB
cord-253295-82ydczid	108	5	isolated	isolate	VBN
cord-253295-82ydczid	108	6	from	from	IN
cord-253295-82ydczid	108	7	a	a	DT
cord-253295-82ydczid	108	8	diseased	diseased	JJ
cord-253295-82ydczid	108	9	individual	individual	NN
cord-253295-82ydczid	108	10	and	and	CC
cord-253295-82ydczid	108	11	grown	grow	VBN
cord-253295-82ydczid	108	12	in	in	IN
cord-253295-82ydczid	108	13	pure	pure	JJ
cord-253295-82ydczid	108	14	culture	culture	NN
cord-253295-82ydczid	108	15	,	,	,
cord-253295-82ydczid	108	16	(	(	-LRB-
cord-253295-82ydczid	108	17	iii	iii	NN
cord-253295-82ydczid	108	18	)	)	-RRB-
cord-253295-82ydczid	108	19	the	the	DT
cord-253295-82ydczid	108	20	specific	specific	JJ
cord-253295-82ydczid	108	21	disease	disease	NN
cord-253295-82ydczid	108	22	must	must	MD
cord-253295-82ydczid	108	23	be	be	VB
cord-253295-82ydczid	108	24	reproduced	reproduce	VBN
cord-253295-82ydczid	108	25	when	when	WRB
cord-253295-82ydczid	108	26	a	a	DT
cord-253295-82ydczid	108	27	pure	pure	JJ
cord-253295-82ydczid	108	28	culture	culture	NN
cord-253295-82ydczid	108	29	is	be	VBZ
cord-253295-82ydczid	108	30	inoculated	inoculate	VBN
cord-253295-82ydczid	108	31	into	into	IN
cord-253295-82ydczid	108	32	a	a	DT
cord-253295-82ydczid	108	33	healthy	healthy	JJ
cord-253295-82ydczid	108	34	susceptible	susceptible	JJ
cord-253295-82ydczid	108	35	host	host	NN
cord-253295-82ydczid	108	36	,	,	,
cord-253295-82ydczid	108	37	and	and	CC
cord-253295-82ydczid	108	38	(	(	-LRB-
cord-253295-82ydczid	108	39	iv	iv	LS
cord-253295-82ydczid	108	40	)	)	-RRB-
cord-253295-82ydczid	108	41	the	the	DT
cord-253295-82ydczid	108	42	same	same	JJ
cord-253295-82ydczid	108	43	bacteria	bacteria	NNS
cord-253295-82ydczid	108	44	must	must	MD
cord-253295-82ydczid	108	45	be	be	VB
cord-253295-82ydczid	108	46	recoverable	recoverable	JJ
cord-253295-82ydczid	108	47	from	from	IN
cord-253295-82ydczid	108	48	the	the	DT
cord-253295-82ydczid	108	49	experimentally	experimentally	RB
cord-253295-82ydczid	108	50	infected	infect	VBN
cord-253295-82ydczid	108	51	host	host	NN
cord-253295-82ydczid	108	52	.	.	.
cord-253295-82ydczid	109	1	Viruses	virus	NNS
cord-253295-82ydczid	109	2	,	,	,
cord-253295-82ydczid	109	3	like	like	IN
cord-253295-82ydczid	109	4	bacteria	bacteria	NNS
cord-253295-82ydczid	109	5	,	,	,
cord-253295-82ydczid	109	6	were	be	VBD
cord-253295-82ydczid	109	7	understood	understand	VBN
cord-253295-82ydczid	109	8	and	and	CC
cord-253295-82ydczid	109	9	manipulated	manipulate	VBN
cord-253295-82ydczid	109	10	clinically	clinically	RB
cord-253295-82ydczid	109	11	prior	prior	RB
cord-253295-82ydczid	109	12	to	to	IN
cord-253295-82ydczid	109	13	their	-PRON-	PRP$
cord-253295-82ydczid	109	14	isolation	isolation	NN
cord-253295-82ydczid	109	15	.	.	.
cord-253295-82ydczid	110	1	Manipulation	manipulation	NN
cord-253295-82ydczid	110	2	of	of	IN
cord-253295-82ydczid	110	3	viruses	virus	NNS
cord-253295-82ydczid	110	4	as	as	IN
cord-253295-82ydczid	110	5	vaccines	vaccine	NNS
cord-253295-82ydczid	110	6	is	be	VBZ
cord-253295-82ydczid	110	7	traced	trace	VBN
cord-253295-82ydczid	110	8	to	to	IN
cord-253295-82ydczid	110	9	description	description	NN
cord-253295-82ydczid	110	10	of	of	IN
cord-253295-82ydczid	110	11	smallpox	smallpox	NN
cord-253295-82ydczid	110	12	variolation	variolation	NN
cord-253295-82ydczid	110	13	in	in	IN
cord-253295-82ydczid	110	14	Turkey	Turkey	NNP
cord-253295-82ydczid	110	15	by	by	IN
cord-253295-82ydczid	110	16	at	at	RB
cord-253295-82ydczid	110	17	least	least	JJS
cord-253295-82ydczid	110	18	1718	1718	CD
cord-253295-82ydczid	110	19	(	(	-LRB-
cord-253295-82ydczid	110	20	described	describe	VBN
cord-253295-82ydczid	110	21	by	by	IN
cord-253295-82ydczid	110	22	Lady	Lady	NNP
cord-253295-82ydczid	110	23	Montagu	Montagu	NNP
cord-253295-82ydczid	110	24	)	)	-RRB-
cord-253295-82ydczid	110	25	.	.	.
cord-253295-82ydczid	111	1	Smallpox	smallpox	NN
cord-253295-82ydczid	111	2	variolation	variolation	NN
cord-253295-82ydczid	111	3	was	be	VBD
cord-253295-82ydczid	111	4	used	use	VBN
cord-253295-82ydczid	111	5	in	in	IN
cord-253295-82ydczid	111	6	the	the	DT
cord-253295-82ydczid	111	7	US	US	NNP
cord-253295-82ydczid	111	8	continental	continental	JJ
cord-253295-82ydczid	111	9	army	army	NN
cord-253295-82ydczid	111	10	in	in	IN
cord-253295-82ydczid	111	11	the	the	DT
cord-253295-82ydczid	111	12	1770s	1770	NNS
cord-253295-82ydczid	111	13	.	.	.
cord-253295-82ydczid	112	1	Local	local	JJ
cord-253295-82ydczid	112	2	availability	availability	NN
cord-253295-82ydczid	112	3	of	of	IN
cord-253295-82ydczid	112	4	cowpox	cowpox	NN
cord-253295-82ydczid	112	5	,	,	,
cord-253295-82ydczid	112	6	a	a	DT
cord-253295-82ydczid	112	7	non	non	JJ
cord-253295-82ydczid	112	8	-	-	JJ
cord-253295-82ydczid	112	9	lethal	lethal	JJ
cord-253295-82ydczid	112	10	poxvirus	poxvirus	NN
cord-253295-82ydczid	112	11	,	,	,
cord-253295-82ydczid	112	12	allowed	allow	VBD
cord-253295-82ydczid	112	13	Jenner	Jenner	NNP
cord-253295-82ydczid	112	14	to	to	TO
cord-253295-82ydczid	112	15	demonstrate	demonstrate	VB
cord-253295-82ydczid	112	16	(	(	-LRB-
cord-253295-82ydczid	112	17	cross-	cross-	NN
cord-253295-82ydczid	112	18	)	)	-RRB-
cord-253295-82ydczid	112	19	vaccination	vaccination	NN
cord-253295-82ydczid	112	20	against	against	IN
cord-253295-82ydczid	112	21	smallpox	smallpox	NN
cord-253295-82ydczid	112	22	(	(	-LRB-
cord-253295-82ydczid	112	23	1796	1796	CD
cord-253295-82ydczid	112	24	)	)	-RRB-
cord-253295-82ydczid	112	25	.	.	.
cord-253295-82ydczid	113	1	Vaccination	vaccination	NN
cord-253295-82ydczid	113	2	against	against	IN
cord-253295-82ydczid	113	3	smallpox	smallpox	NN
cord-253295-82ydczid	113	4	was	be	VBD
cord-253295-82ydczid	113	5	used	use	VBN
cord-253295-82ydczid	113	6	in	in	IN
cord-253295-82ydczid	113	7	Napolean	Napolean	NNP
cord-253295-82ydczid	113	8	's	's	POS
cord-253295-82ydczid	113	9	army	army	NN
cord-253295-82ydczid	113	10	in	in	IN
cord-253295-82ydczid	113	11	1812	1812	CD
cord-253295-82ydczid	113	12	,	,	,
cord-253295-82ydczid	113	13	and	and	CC
cord-253295-82ydczid	113	14	was	be	VBD
cord-253295-82ydczid	113	15	mandated	mandate	VBN
cord-253295-82ydczid	113	16	for	for	IN
cord-253295-82ydczid	113	17	Massachusetts	Massachusetts	NNP
cord-253295-82ydczid	113	18	schoolchildren	schoolchildren	NNS
cord-253295-82ydczid	113	19	by	by	IN
cord-253295-82ydczid	113	20	1855	1855	CD
cord-253295-82ydczid	113	21	.	.	.
cord-253295-82ydczid	114	1	The	the	DT
cord-253295-82ydczid	114	2	success	success	NN
cord-253295-82ydczid	114	3	of	of	IN
cord-253295-82ydczid	114	4	these	these	DT
cord-253295-82ydczid	114	5	vaccination	vaccination	NN
cord-253295-82ydczid	114	6	programs	program	NNS
cord-253295-82ydczid	114	7	prompted	prompt	VBD
cord-253295-82ydczid	114	8	development	development	NN
cord-253295-82ydczid	114	9	of	of	IN
cord-253295-82ydczid	114	10	vaccines	vaccine	NNS
cord-253295-82ydczid	114	11	against	against	IN
cord-253295-82ydczid	114	12	other	other	JJ
cord-253295-82ydczid	114	13	human	human	JJ
cord-253295-82ydczid	114	14	viruses	virus	NNS
cord-253295-82ydczid	114	15	through	through	IN
cord-253295-82ydczid	114	16	the	the	DT
cord-253295-82ydczid	114	17	19th	19th	JJ
cord-253295-82ydczid	114	18	and	and	CC
cord-253295-82ydczid	114	19	20th	20th	JJ
cord-253295-82ydczid	114	20	centuries	century	NNS
cord-253295-82ydczid	114	21	,	,	,
cord-253295-82ydczid	114	22	including	include	VBG
cord-253295-82ydczid	114	23	rabies	rabie	NNS
cord-253295-82ydczid	114	24	(	(	-LRB-
cord-253295-82ydczid	114	25	 	 	_SP
cord-253295-82ydczid	114	26	Prior	prior	RB
cord-253295-82ydczid	114	27	to	to	IN
cord-253295-82ydczid	114	28	1828	1828	CD
cord-253295-82ydczid	114	29	,	,	,
cord-253295-82ydczid	114	30	organic	organic	JJ
cord-253295-82ydczid	114	31	(	(	-LRB-
cord-253295-82ydczid	114	32	carbon	carbon	NN
cord-253295-82ydczid	114	33	-	-	HYPH
cord-253295-82ydczid	114	34	containing	contain	VBG
cord-253295-82ydczid	114	35	)	)	-RRB-
cord-253295-82ydczid	114	36	compounds	compound	NNS
cord-253295-82ydczid	114	37	were	be	VBD
cord-253295-82ydczid	114	38	thought	think	VBN
cord-253295-82ydczid	114	39	to	to	TO
cord-253295-82ydczid	114	40	derive	derive	VB
cord-253295-82ydczid	114	41	from	from	IN
cord-253295-82ydczid	114	42	living	live	VBG
cord-253295-82ydczid	114	43	organisms	organism	NNS
cord-253295-82ydczid	114	44	,	,	,
cord-253295-82ydczid	114	45	and	and	CC
cord-253295-82ydczid	114	46	it	-PRON-	PRP
cord-253295-82ydczid	114	47	was	be	VBD
cord-253295-82ydczid	114	48	thought	think	VBN
cord-253295-82ydczid	114	49	that	that	IN
cord-253295-82ydczid	114	50	they	-PRON-	PRP
cord-253295-82ydczid	114	51	could	could	MD
cord-253295-82ydczid	114	52	never	never	RB
cord-253295-82ydczid	114	53	be	be	VB
cord-253295-82ydczid	114	54	synthesized	synthesize	VBN
cord-253295-82ydczid	114	55	from	from	IN
cord-253295-82ydczid	114	56	nonliving	nonlive	VBG
cord-253295-82ydczid	114	57	(	(	-LRB-
cord-253295-82ydczid	114	58	inorganic	inorganic	JJ
cord-253295-82ydczid	114	59	)	)	-RRB-
cord-253295-82ydczid	114	60	material	material	NN
cord-253295-82ydczid	114	61	.	.	.
cord-253295-82ydczid	115	1	This	this	DT
cord-253295-82ydczid	115	2	concept	concept	NN
cord-253295-82ydczid	115	3	(	(	-LRB-
cord-253295-82ydczid	115	4	'	'	``
cord-253295-82ydczid	115	5	vitalism	vitalism	NN
cord-253295-82ydczid	115	6	'	'	''
cord-253295-82ydczid	115	7	)	)	-RRB-
cord-253295-82ydczid	115	8	was	be	VBD
cord-253295-82ydczid	115	9	disproven	disproven	VBN
cord-253295-82ydczid	115	10	by	by	IN
cord-253295-82ydczid	115	11	the	the	DT
cord-253295-82ydczid	115	12	in	in	FW
cord-253295-82ydczid	115	13	vitro	vitro	FW
cord-253295-82ydczid	115	14	synthesis	synthesis	NN
cord-253295-82ydczid	115	15	of	of	IN
cord-253295-82ydczid	115	16	urea	urea	NN
cord-253295-82ydczid	115	17	by	by	IN
cord-253295-82ydczid	115	18	F.	F.	NNP
cord-253295-82ydczid	115	19	Wohler	Wohler	NNP
cord-253295-82ydczid	115	20	in	in	IN
cord-253295-82ydczid	115	21	1828	1828	CD
cord-253295-82ydczid	115	22	.	.	.
cord-253295-82ydczid	116	1	Work	work	VB
cord-253295-82ydczid	116	2	from	from	IN
cord-253295-82ydczid	116	3	this	this	DT
cord-253295-82ydczid	116	4	era	era	NN
cord-253295-82ydczid	116	5	initiated	initiate	VBD
cord-253295-82ydczid	116	6	the	the	DT
cord-253295-82ydczid	116	7	field	field	NN
cord-253295-82ydczid	116	8	of	of	IN
cord-253295-82ydczid	116	9	organic	organic	JJ
cord-253295-82ydczid	116	10	chemistry	chemistry	NN
cord-253295-82ydczid	116	11	.	.	.
cord-253295-82ydczid	117	1	Predictable	predictable	JJ
cord-253295-82ydczid	117	2	rules	rule	NNS
cord-253295-82ydczid	117	3	for	for	IN
cord-253295-82ydczid	117	4	in	in	FW
cord-253295-82ydczid	117	5	vitro	vitro	FW
cord-253295-82ydczid	117	6	and	and	CC
cord-253295-82ydczid	117	7	in	in	IN
cord-253295-82ydczid	117	8	vivo	vivo	NNP
cord-253295-82ydczid	117	9	organic	organic	JJ
cord-253295-82ydczid	117	10	reactions	reaction	NNS
cord-253295-82ydczid	117	11	,	,	,
cord-253295-82ydczid	117	12	structural	structural	JJ
cord-253295-82ydczid	117	13	theory	theory	NN
cord-253295-82ydczid	117	14	,	,	,
cord-253295-82ydczid	117	15	modeling	modeling	NN
cord-253295-82ydczid	117	16	,	,	,
cord-253295-82ydczid	117	17	separation	separation	NN
cord-253295-82ydczid	117	18	technologies	technology	NNS
cord-253295-82ydczid	117	19	,	,	,
cord-253295-82ydczid	117	20	and	and	CC
cord-253295-82ydczid	117	21	accurate	accurate	JJ
cord-253295-82ydczid	117	22	measurement	measurement	NN
cord-253295-82ydczid	117	23	subsequently	subsequently	RB
cord-253295-82ydczid	117	24	allowed	allow	VBD
cord-253295-82ydczid	117	25	the	the	DT
cord-253295-82ydczid	117	26	chemical	chemical	JJ
cord-253295-82ydczid	117	27	description	description	NN
cord-253295-82ydczid	117	28	of	of	IN
cord-253295-82ydczid	117	29	natural	natural	JJ
cord-253295-82ydczid	117	30	products	product	NNS
cord-253295-82ydczid	117	31	,	,	,
cord-253295-82ydczid	117	32	and	and	CC
cord-253295-82ydczid	117	33	the	the	DT
cord-253295-82ydczid	117	34	chemical	chemical	JJ
cord-253295-82ydczid	117	35	synthesis	synthesis	NN
cord-253295-82ydczid	117	36	of	of	IN
cord-253295-82ydczid	117	37	both	both	DT
cord-253295-82ydczid	117	38	natural	natural	JJ
cord-253295-82ydczid	117	39	products	product	NNS
cord-253295-82ydczid	117	40	and	and	CC
cord-253295-82ydczid	117	41	synthetic	synthetic	JJ
cord-253295-82ydczid	117	42	compounds	compound	NNS
cord-253295-82ydczid	117	43	.	.	.
cord-253295-82ydczid	118	1	In	in	IN
cord-253295-82ydczid	118	2	addition	addition	NN
cord-253295-82ydczid	118	3	to	to	IN
cord-253295-82ydczid	118	4	setting	set	VBG
cord-253295-82ydczid	118	5	the	the	DT
cord-253295-82ydczid	118	6	stage	stage	NN
cord-253295-82ydczid	118	7	for	for	IN
cord-253295-82ydczid	118	8	a	a	DT
cord-253295-82ydczid	118	9	systematic	systematic	JJ
cord-253295-82ydczid	118	10	understanding	understanding	NN
cord-253295-82ydczid	118	11	of	of	IN
cord-253295-82ydczid	118	12	cellular	cellular	JJ
cord-253295-82ydczid	118	13	biochemistry	biochemistry	NN
cord-253295-82ydczid	118	14	and	and	CC
cord-253295-82ydczid	118	15	physiology	physiology	NN
cord-253295-82ydczid	118	16	,	,	,
cord-253295-82ydczid	118	17	organic	organic	JJ
cord-253295-82ydczid	118	18	chemistry	chemistry	NN
cord-253295-82ydczid	118	19	set	set	VBD
cord-253295-82ydczid	118	20	the	the	DT
cord-253295-82ydczid	118	21	stage	stage	NN
cord-253295-82ydczid	118	22	for	for	IN
cord-253295-82ydczid	118	23	laboratory	laboratory	NN
cord-253295-82ydczid	118	24	synthesis	synthesis	NN
cord-253295-82ydczid	118	25	of	of	IN
cord-253295-82ydczid	118	26	natural	natural	JJ
cord-253295-82ydczid	118	27	products	product	NNS
cord-253295-82ydczid	118	28	,	,	,
cord-253295-82ydczid	118	29	such	such	JJ
cord-253295-82ydczid	118	30	as	as	IN
cord-253295-82ydczid	118	31	dyes	dye	NNS
cord-253295-82ydczid	118	32	,	,	,
cord-253295-82ydczid	118	33	vitamins	vitamin	NNS
cord-253295-82ydczid	118	34	,	,	,
cord-253295-82ydczid	118	35	hormones	hormone	NNS
cord-253295-82ydczid	118	36	,	,	,
cord-253295-82ydczid	118	37	proteins	protein	NNS
cord-253295-82ydczid	118	38	,	,	,
cord-253295-82ydczid	118	39	and	and	CC
cord-253295-82ydczid	118	40	nucleic	nucleic	JJ
cord-253295-82ydczid	118	41	acids	acid	NNS
cord-253295-82ydczid	118	42	.	.	.
cord-253295-82ydczid	119	1	In	in	IN
cord-253295-82ydczid	119	2	that	that	DT
cord-253295-82ydczid	119	3	era	era	NN
cord-253295-82ydczid	119	4	,	,	,
cord-253295-82ydczid	119	5	the	the	DT
cord-253295-82ydczid	119	6	textile	textile	NN
cord-253295-82ydczid	119	7	industry	industry	NN
cord-253295-82ydczid	119	8	was	be	VBD
cord-253295-82ydczid	119	9	the	the	DT
cord-253295-82ydczid	119	10	main	main	JJ
cord-253295-82ydczid	119	11	consumer	consumer	NN
cord-253295-82ydczid	119	12	of	of	IN
cord-253295-82ydczid	119	13	dyes	dye	NNS
cord-253295-82ydczid	119	14	.	.	.
cord-253295-82ydczid	120	1	Access	access	NN
cord-253295-82ydczid	120	2	to	to	IN
cord-253295-82ydczid	120	3	imported	import	VBN
cord-253295-82ydczid	120	4	natural	natural	JJ
cord-253295-82ydczid	120	5	product	product	NN
cord-253295-82ydczid	120	6	dyes	dye	NNS
cord-253295-82ydczid	120	7	from	from	IN
cord-253295-82ydczid	120	8	plants	plant	NNS
cord-253295-82ydczid	120	9	was	be	VBD
cord-253295-82ydczid	120	10	predictable	predictable	JJ
cord-253295-82ydczid	120	11	for	for	IN
cord-253295-82ydczid	120	12	seafaring	seafaring	JJ
cord-253295-82ydczid	120	13	nations	nation	NNS
cord-253295-82ydczid	120	14	,	,	,
cord-253295-82ydczid	120	15	but	but	CC
cord-253295-82ydczid	120	16	not	not	RB
cord-253295-82ydczid	120	17	for	for	IN
cord-253295-82ydczid	120	18	landlocked	landlocked	JJ
cord-253295-82ydczid	120	19	nations	nation	NNS
cord-253295-82ydczid	120	20	.	.	.
cord-253295-82ydczid	121	1	In	in	IN
cord-253295-82ydczid	121	2	parallel	parallel	NN
cord-253295-82ydczid	121	3	with	with	IN
cord-253295-82ydczid	121	4	natural	natural	JJ
cord-253295-82ydczid	121	5	product	product	NN
cord-253295-82ydczid	121	6	extraction	extraction	NN
cord-253295-82ydczid	121	7	and	and	CC
cord-253295-82ydczid	121	8	purification	purification	NN
cord-253295-82ydczid	121	9	was	be	VBD
cord-253295-82ydczid	121	10	the	the	DT
cord-253295-82ydczid	121	11	recognition	recognition	NN
cord-253295-82ydczid	121	12	that	that	IN
cord-253295-82ydczid	121	13	aniline	aniline	NN
cord-253295-82ydczid	121	14	from	from	IN
cord-253295-82ydczid	121	15	coal	coal	NN
cord-253295-82ydczid	121	16	(	(	-LRB-
cord-253295-82ydczid	121	17	Perkin	Perkin	NNP
cord-253295-82ydczid	121	18	,	,	,
cord-253295-82ydczid	121	19	1856	1856	CD
cord-253295-82ydczid	121	20	)	)	-RRB-
cord-253295-82ydczid	121	21	could	could	MD
cord-253295-82ydczid	121	22	be	be	VB
cord-253295-82ydczid	121	23	modified	modify	VBN
cord-253295-82ydczid	121	24	to	to	TO
cord-253295-82ydczid	121	25	generate	generate	VB
cord-253295-82ydczid	121	26	a	a	DT
cord-253295-82ydczid	121	27	spectrum	spectrum	NN
cord-253295-82ydczid	121	28	of	of	IN
cord-253295-82ydczid	121	29	colors	color	NNS
cord-253295-82ydczid	121	30	,	,	,
cord-253295-82ydczid	121	31	catalyzing	catalyze	VBG
cord-253295-82ydczid	121	32	the	the	DT
cord-253295-82ydczid	121	33	development	development	NN
cord-253295-82ydczid	121	34	of	of	IN
cord-253295-82ydczid	121	35	the	the	DT
cord-253295-82ydczid	121	36	German	german	JJ
cord-253295-82ydczid	121	37	dye	dye	NN
cord-253295-82ydczid	121	38	industry	industry	NN
cord-253295-82ydczid	121	39	in	in	IN
cord-253295-82ydczid	121	40	the	the	DT
cord-253295-82ydczid	121	41	last	last	JJ
cord-253295-82ydczid	121	42	half	half	NN
cord-253295-82ydczid	121	43	of	of	IN
cord-253295-82ydczid	121	44	the	the	DT
cord-253295-82ydczid	121	45	19th	19th	JJ
cord-253295-82ydczid	121	46	century	century	NN
cord-253295-82ydczid	121	47	.	.	.
cord-253295-82ydczid	122	1	Some	some	DT
cord-253295-82ydczid	122	2	of	of	IN
cord-253295-82ydczid	122	3	these	these	DT
cord-253295-82ydczid	122	4	synthetic	synthetic	JJ
cord-253295-82ydczid	122	5	dyes	dye	NNS
cord-253295-82ydczid	122	6	were	be	VBD
cord-253295-82ydczid	122	7	found	find	VBN
cord-253295-82ydczid	122	8	useful	useful	JJ
cord-253295-82ydczid	122	9	for	for	IN
cord-253295-82ydczid	122	10	histochemical	histochemical	JJ
cord-253295-82ydczid	122	11	staining	staining	NN
cord-253295-82ydczid	122	12	.	.	.
cord-253295-82ydczid	123	1	Morphologic	morphologic	JJ
cord-253295-82ydczid	123	2	diagnosis	diagnosis	NN
cord-253295-82ydczid	123	3	requires	require	VBZ
cord-253295-82ydczid	123	4	thin	thin	JJ
cord-253295-82ydczid	123	5	(	(	-LRB-
cord-253295-82ydczid	123	6	3À5	3à5	CD
cord-253295-82ydczid	123	7	μm	μm	NN
cord-253295-82ydczid	123	8	)	)	-RRB-
cord-253295-82ydczid	123	9	,	,	,
cord-253295-82ydczid	123	10	contrast	contrast	NN
cord-253295-82ydczid	123	11	-	-	HYPH
cord-253295-82ydczid	123	12	rich	rich	JJ
cord-253295-82ydczid	123	13	(	(	-LRB-
cord-253295-82ydczid	123	14	requiring	require	VBG
cord-253295-82ydczid	123	15	dyes	dye	NNS
cord-253295-82ydczid	123	16	)	)	-RRB-
cord-253295-82ydczid	123	17	sections	section	NNS
cord-253295-82ydczid	123	18	of	of	IN
cord-253295-82ydczid	123	19	chemically	chemically	RB
cord-253295-82ydczid	123	20	fixed	fix	VBN
cord-253295-82ydczid	123	21	(	(	-LRB-
cord-253295-82ydczid	123	22	cross	cross	NN
cord-253295-82ydczid	123	23	-	-	JJ
cord-253295-82ydczid	123	24	linked	link	VBN
cord-253295-82ydczid	123	25	or	or	CC
cord-253295-82ydczid	123	26	precipitated	precipitate	VBN
cord-253295-82ydczid	123	27	)	)	-RRB-
cord-253295-82ydczid	123	28	tissue	tissue	NN
cord-253295-82ydczid	123	29	.	.	.
cord-253295-82ydczid	124	1	Thin	thin	JJ
cord-253295-82ydczid	124	2	sections	section	NNS
cord-253295-82ydczid	124	3	allow	allow	VBP
cord-253295-82ydczid	124	4	the	the	DT
cord-253295-82ydczid	124	5	passage	passage	NN
cord-253295-82ydczid	124	6	of	of	IN
cord-253295-82ydczid	124	7	light	light	NN
cord-253295-82ydczid	124	8	through	through	IN
cord-253295-82ydczid	124	9	the	the	DT
cord-253295-82ydczid	124	10	tissue	tissue	NN
cord-253295-82ydczid	124	11	,	,	,
cord-253295-82ydczid	124	12	but	but	CC
cord-253295-82ydczid	124	13	reduce	reduce	VB
cord-253295-82ydczid	124	14	overlapping	overlapping	NN
cord-253295-82ydczid	124	15	of	of	IN
cord-253295-82ydczid	124	16	cells	cell	NNS
cord-253295-82ydczid	124	17	in	in	IN
cord-253295-82ydczid	124	18	the	the	DT
cord-253295-82ydczid	124	19	light	light	JJ
cord-253295-82ydczid	124	20	path	path	NN
cord-253295-82ydczid	124	21	.	.	.
cord-253295-82ydczid	125	1	Thus	thus	RB
cord-253295-82ydczid	125	2	,	,	,
cord-253295-82ydczid	125	3	technologies	technology	NNS
cord-253295-82ydczid	125	4	had	have	VBD
cord-253295-82ydczid	125	5	to	to	TO
cord-253295-82ydczid	125	6	develop	develop	VB
cord-253295-82ydczid	125	7	for	for	IN
cord-253295-82ydczid	125	8	cutting	cut	VBG
cord-253295-82ydczid	125	9	and	and	CC
cord-253295-82ydczid	125	10	staining	staining	NN
cord-253295-82ydczid	125	11	of	of	IN
cord-253295-82ydczid	125	12	thin	thin	JJ
cord-253295-82ydczid	125	13	fixed	fix	VBN
cord-253295-82ydczid	125	14	tissue	tissue	NN
cord-253295-82ydczid	125	15	sections	section	NNS
cord-253295-82ydczid	125	16	.	.	.
cord-253295-82ydczid	126	1	Work	work	NN
cord-253295-82ydczid	126	2	leading	lead	VBG
cord-253295-82ydczid	126	3	to	to	IN
cord-253295-82ydczid	126	4	our	-PRON-	PRP$
cord-253295-82ydczid	126	5	current	current	JJ
cord-253295-82ydczid	126	6	technique	technique	NN
cord-253295-82ydczid	126	7	for	for	IN
cord-253295-82ydczid	126	8	tissue	tissue	NN
cord-253295-82ydczid	126	9	solidification	solidification	NN
cord-253295-82ydczid	126	10	in	in	IN
cord-253295-82ydczid	126	11	paraffin	paraffin	NN
cord-253295-82ydczid	126	12	wax	wax	NN
cord-253295-82ydczid	126	13	was	be	VBD
cord-253295-82ydczid	126	14	first	first	RB
cord-253295-82ydczid	126	15	described	describe	VBN
cord-253295-82ydczid	126	16	by	by	IN
cord-253295-82ydczid	126	17	Klebs	Klebs	NNP
cord-253295-82ydczid	126	18	in	in	IN
cord-253295-82ydczid	126	19	1869	1869	CD
cord-253295-82ydczid	126	20	.	.	.
cord-253295-82ydczid	127	1	Prototypes	prototype	NNS
cord-253295-82ydczid	127	2	of	of	IN
cord-253295-82ydczid	127	3	our	-PRON-	PRP$
cord-253295-82ydczid	127	4	current	current	JJ
cord-253295-82ydczid	127	5	mechanical	mechanical	JJ
cord-253295-82ydczid	127	6	microtome	microtome	NN
cord-253295-82ydczid	127	7	for	for	IN
cord-253295-82ydczid	127	8	making	make	VBG
cord-253295-82ydczid	127	9	thin	thin	JJ
cord-253295-82ydczid	127	10	(	(	-LRB-
cord-253295-82ydczid	127	11	~5	~5	.
cord-253295-82ydczid	128	1	μm	μm	NNP
cord-253295-82ydczid	128	2	thick	thick	JJ
cord-253295-82ydczid	128	3	)	)	-RRB-
cord-253295-82ydczid	128	4	tissue	tissue	NN
cord-253295-82ydczid	128	5	sections	section	NNS
cord-253295-82ydczid	128	6	was	be	VBD
cord-253295-82ydczid	128	7	developed	develop	VBN
cord-253295-82ydczid	128	8	by	by	IN
cord-253295-82ydczid	128	9	Minot	Minot	NNP
cord-253295-82ydczid	128	10	in	in	IN
cord-253295-82ydczid	128	11	1885	1885	CD
cord-253295-82ydczid	128	12	.	.	.
cord-253295-82ydczid	129	1	Precursor	precursor	NN
cord-253295-82ydczid	129	2	work	work	NN
cord-253295-82ydczid	129	3	leading	lead	VBG
cord-253295-82ydczid	129	4	to	to	IN
cord-253295-82ydczid	129	5	our	-PRON-	PRP$
cord-253295-82ydczid	129	6	current	current	JJ
cord-253295-82ydczid	129	7	technique	technique	NN
cord-253295-82ydczid	129	8	for	for	IN
cord-253295-82ydczid	129	9	tissue	tissue	NN
cord-253295-82ydczid	129	10	fixation	fixation	NN
cord-253295-82ydczid	129	11	with	with	IN
cord-253295-82ydczid	129	12	diluted	dilute	VBN
cord-253295-82ydczid	129	13	formalin	formalin	NN
cord-253295-82ydczid	129	14	was	be	VBD
cord-253295-82ydczid	129	15	first	first	RB
cord-253295-82ydczid	129	16	described	describe	VBN
cord-253295-82ydczid	129	17	by	by	IN
cord-253295-82ydczid	129	18	Blum	Blum	NNP
cord-253295-82ydczid	129	19	in	in	IN
cord-253295-82ydczid	129	20	1893	1893	CD
cord-253295-82ydczid	129	21	.	.	.
cord-253295-82ydczid	130	1	Histochemical	Histochemical	NNP
cord-253295-82ydczid	130	2	stains	stain	NNS
cord-253295-82ydczid	130	3	developed	develop	VBN
cord-253295-82ydczid	130	4	in	in	IN
cord-253295-82ydczid	130	5	parallel	parallel	NN
cord-253295-82ydczid	130	6	with	with	IN
cord-253295-82ydczid	130	7	dye	dye	NN
cord-253295-82ydczid	130	8	technology	technology	NN
cord-253295-82ydczid	130	9	for	for	IN
cord-253295-82ydczid	130	10	the	the	DT
cord-253295-82ydczid	130	11	textile	textile	NN
cord-253295-82ydczid	130	12	industry	industry	NN
cord-253295-82ydczid	130	13	.	.	.
cord-253295-82ydczid	131	1	Botanists	botanist	NNS
cord-253295-82ydczid	131	2	used	use	VBD
cord-253295-82ydczid	131	3	carmine	carmine	NNP
cord-253295-82ydczid	131	4	as	as	IN
cord-253295-82ydczid	131	5	a	a	DT
cord-253295-82ydczid	131	6	stain	stain	NN
cord-253295-82ydczid	131	7	in	in	IN
cord-253295-82ydczid	131	8	1849	1849	CD
cord-253295-82ydczid	131	9	,	,	,
cord-253295-82ydczid	131	10	and	and	CC
cord-253295-82ydczid	131	11	subsequently	subsequently	RB
cord-253295-82ydczid	131	12	Gerlack	Gerlack	NNP
cord-253295-82ydczid	131	13	applied	apply	VBD
cord-253295-82ydczid	131	14	carmine	carmine	NNP
cord-253295-82ydczid	131	15	to	to	TO
cord-253295-82ydczid	131	16	stain	stain	VB
cord-253295-82ydczid	131	17	brain	brain	NN
cord-253295-82ydczid	131	18	tissue	tissue	NN
cord-253295-82ydczid	131	19	in	in	IN
cord-253295-82ydczid	131	20	1858	1858	CD
cord-253295-82ydczid	131	21	.	.	.
cord-253295-82ydczid	132	1	The	the	DT
cord-253295-82ydczid	132	2	current	current	JJ
cord-253295-82ydczid	132	3	hematoxylin	hematoxylin	NN
cord-253295-82ydczid	132	4	dye	dye	NN
cord-253295-82ydczid	132	5	used	use	VBN
cord-253295-82ydczid	132	6	in	in	IN
cord-253295-82ydczid	132	7	tissue	tissue	NN
cord-253295-82ydczid	132	8	histochemistry	histochemistry	NNP
cord-253295-82ydczid	132	9	was	be	VBD
cord-253295-82ydczid	132	10	originally	originally	RB
cord-253295-82ydczid	132	11	extracted	extract	VBN
cord-253295-82ydczid	132	12	from	from	IN
cord-253295-82ydczid	132	13	logwood	logwood	NN
cord-253295-82ydczid	132	14	trees	tree	NNS
cord-253295-82ydczid	132	15	from	from	IN
cord-253295-82ydczid	132	16	Central	Central	NNP
cord-253295-82ydczid	132	17	America	America	NNP
cord-253295-82ydczid	132	18	for	for	IN
cord-253295-82ydczid	132	19	the	the	DT
cord-253295-82ydczid	132	20	dye	dye	NN
cord-253295-82ydczid	132	21	industry	industry	NN
cord-253295-82ydczid	132	22	(	(	-LRB-
cord-253295-82ydczid	132	23	to	to	TO
cord-253295-82ydczid	132	24	compete	compete	VB
cord-253295-82ydczid	132	25	with	with	IN
cord-253295-82ydczid	132	26	indigo	indigo	NN
cord-253295-82ydczid	132	27	)	)	-RRB-
cord-253295-82ydczid	132	28	.	.	.
cord-253295-82ydczid	133	1	Metallic	metallic	JJ
cord-253295-82ydczid	133	2	ion	ion	NN
cord-253295-82ydczid	133	3	mordants	mordant	NNS
cord-253295-82ydczid	133	4	made	make	VBD
cord-253295-82ydczid	133	5	oxidized	oxidize	VBN
cord-253295-82ydczid	133	6	hematoxylin	hematoxylin	NNP
cord-253295-82ydczid	133	7	(	(	-LRB-
cord-253295-82ydczid	133	8	hematein	hematein	NNP
cord-253295-82ydczid	133	9	)	)	-RRB-
cord-253295-82ydczid	133	10	colorfast	colorfast	JJ
cord-253295-82ydczid	133	11	in	in	IN
cord-253295-82ydczid	133	12	textiles	textile	NNS
cord-253295-82ydczid	133	13	,	,	,
cord-253295-82ydczid	133	14	and	and	CC
cord-253295-82ydczid	133	15	a	a	DT
cord-253295-82ydczid	133	16	protocol	protocol	NN
cord-253295-82ydczid	133	17	for	for	IN
cord-253295-82ydczid	133	18	tissue	tissue	NN
cord-253295-82ydczid	133	19	staining	staining	NN
cord-253295-82ydczid	133	20	was	be	VBD
cord-253295-82ydczid	133	21	published	publish	VBN
cord-253295-82ydczid	133	22	by	by	IN
cord-253295-82ydczid	133	23	Boehmer	Boehmer	NNP
cord-253295-82ydczid	133	24	in	in	IN
cord-253295-82ydczid	133	25	1865	1865	CD
cord-253295-82ydczid	133	26	.	.	.
cord-253295-82ydczid	134	1	Similar	similar	JJ
cord-253295-82ydczid	134	2	to	to	IN
cord-253295-82ydczid	134	3	the	the	DT
cord-253295-82ydczid	134	4	hematoxylin	hematoxylin	NNP
cord-253295-82ydczid	134	5	story	story	NNP
cord-253295-82ydczid	134	6	,	,	,
cord-253295-82ydczid	134	7	semisynthetic	semisynthetic	JJ
cord-253295-82ydczid	134	8	analine	analine	NN
cord-253295-82ydczid	134	9	dye	dye	NN
cord-253295-82ydczid	134	10	technology	technology	NN
cord-253295-82ydczid	134	11	was	be	VBD
cord-253295-82ydczid	134	12	adapted	adapt	VBN
cord-253295-82ydczid	134	13	by	by	IN
cord-253295-82ydczid	134	14	histochemists	histochemist	NNS
cord-253295-82ydczid	134	15	from	from	IN
cord-253295-82ydczid	134	16	1850	1850	CD
cord-253295-82ydczid	134	17	to	to	IN
cord-253295-82ydczid	134	18	1900	1900	CD
cord-253295-82ydczid	134	19	.	.	.
cord-253295-82ydczid	135	1	Many	many	JJ
cord-253295-82ydczid	135	2	of	of	IN
cord-253295-82ydczid	135	3	these	these	DT
cord-253295-82ydczid	135	4	dyes	dye	NNS
cord-253295-82ydczid	135	5	are	be	VBP
cord-253295-82ydczid	135	6	still	still	RB
cord-253295-82ydczid	135	7	routinely	routinely	RB
cord-253295-82ydczid	135	8	used	use	VBN
cord-253295-82ydczid	135	9	for	for	IN
cord-253295-82ydczid	135	10	recognition	recognition	NN
cord-253295-82ydczid	135	11	of	of	IN
cord-253295-82ydczid	135	12	tissue	tissue	NN
cord-253295-82ydczid	135	13	structure	structure	NN
cord-253295-82ydczid	135	14	,	,	,
cord-253295-82ydczid	135	15	peripheral	peripheral	JJ
cord-253295-82ydczid	135	16	blood	blood	NN
cord-253295-82ydczid	135	17	cells	cell	NNS
cord-253295-82ydczid	135	18	,	,	,
cord-253295-82ydczid	135	19	and	and	CC
cord-253295-82ydczid	135	20	microorganisms	microorganism	NNS
cord-253295-82ydczid	135	21	,	,	,
cord-253295-82ydczid	135	22	including	include	VBG
cord-253295-82ydczid	135	23	hematoxylin	hematoxylin	NNP
cord-253295-82ydczid	135	24	,	,	,
cord-253295-82ydczid	135	25	eosin	eosin	NNP
cord-253295-82ydczid	135	26	,	,	,
cord-253295-82ydczid	135	27	methylene	methylene	NN
cord-253295-82ydczid	135	28	blue	blue	NN
cord-253295-82ydczid	135	29	,	,	,
cord-253295-82ydczid	135	30	Ziehl	Ziehl	NNP
cord-253295-82ydczid	135	31	-	-	HYPH
cord-253295-82ydczid	135	32	Neelsen	Neelsen	NNP
cord-253295-82ydczid	135	33	,	,	,
cord-253295-82ydczid	135	34	Gram	Gram	NNP
cord-253295-82ydczid	135	35	,	,	,
cord-253295-82ydczid	135	36	van	van	NNP
cord-253295-82ydczid	135	37	Gieson	Gieson	NNP
cord-253295-82ydczid	135	38	,	,	,
cord-253295-82ydczid	135	39	Mallory	Mallory	NNP
cord-253295-82ydczid	135	40	trichrome	trichrome	NNP
cord-253295-82ydczid	135	41	,	,	,
cord-253295-82ydczid	135	42	and	and	CC
cord-253295-82ydczid	135	43	Congo	Congo	NNP
cord-253295-82ydczid	135	44	red	red	NN
cord-253295-82ydczid	135	45	.	.	.
cord-253295-82ydczid	136	1	The	the	DT
cord-253295-82ydczid	136	2	most	most	RBS
cord-253295-82ydczid	136	3	commonly	commonly	RB
cord-253295-82ydczid	136	4	used	use	VBN
cord-253295-82ydczid	136	5	stains	stain	NNS
cord-253295-82ydczid	136	6	for	for	IN
cord-253295-82ydczid	136	7	general	general	JJ
cord-253295-82ydczid	136	8	tissue	tissue	NN
cord-253295-82ydczid	136	9	diagnosis	diagnosis	NN
cord-253295-82ydczid	136	10	are	be	VBP
cord-253295-82ydczid	136	11	the	the	DT
cord-253295-82ydczid	136	12	hematoxylin	hematoxylin	NNP
cord-253295-82ydczid	136	13	and	and	CC
cord-253295-82ydczid	136	14	eosin	eosin	NNP
cord-253295-82ydczid	136	15	(	(	-LRB-
cord-253295-82ydczid	136	16	H&E	H&E	NNP
cord-253295-82ydczid	136	17	)	)	-RRB-
cord-253295-82ydczid	136	18	stains	stain	NNS
cord-253295-82ydczid	136	19	,	,	,
cord-253295-82ydczid	136	20	which	which	WDT
cord-253295-82ydczid	136	21	provide	provide	VBP
cord-253295-82ydczid	136	22	a	a	DT
cord-253295-82ydczid	136	23	wealth	wealth	NN
cord-253295-82ydczid	136	24	of	of	IN
cord-253295-82ydczid	136	25	nuclear	nuclear	JJ
cord-253295-82ydczid	136	26	and	and	CC
cord-253295-82ydczid	136	27	cytoplasmic	cytoplasmic	JJ
cord-253295-82ydczid	136	28	detail	detail	NN
cord-253295-82ydczid	136	29	not	not	RB
cord-253295-82ydczid	136	30	visible	visible	JJ
cord-253295-82ydczid	136	31	in	in	IN
cord-253295-82ydczid	136	32	an	an	DT
cord-253295-82ydczid	136	33	unstained	unstained	JJ
cord-253295-82ydczid	136	34	section	section	NN
cord-253295-82ydczid	136	35	.	.	.
cord-253295-82ydczid	137	1	Supplemental	supplemental	JJ
cord-253295-82ydczid	137	2	histochemical	histochemical	JJ
cord-253295-82ydczid	137	3	stains	stain	NNS
cord-253295-82ydczid	137	4	demonstrate	demonstrate	VBP
cord-253295-82ydczid	137	5	specific	specific	JJ
cord-253295-82ydczid	137	6	structures	structure	NNS
cord-253295-82ydczid	137	7	and	and	CC
cord-253295-82ydczid	137	8	organisms	organism	NNS
cord-253295-82ydczid	137	9	:	:	:
cord-253295-82ydczid	137	10	collagen	collagen	NN
cord-253295-82ydczid	137	11	and	and	CC
cord-253295-82ydczid	137	12	muscle	muscle	NN
cord-253295-82ydczid	137	13	(	(	-LRB-
cord-253295-82ydczid	137	14	trichome	trichome	NN
cord-253295-82ydczid	137	15	)	)	-RRB-
cord-253295-82ydczid	137	16	,	,	,
cord-253295-82ydczid	137	17	elastin	elastin	NN
cord-253295-82ydczid	137	18	(	(	-LRB-
cord-253295-82ydczid	137	19	Verhoff	Verhoff	NNP
cord-253295-82ydczid	137	20	-	-	HYPH
cord-253295-82ydczid	137	21	von	von	NNP
cord-253295-82ydczid	137	22	Giessen	Giessen	NNP
cord-253295-82ydczid	137	23	)	)	-RRB-
cord-253295-82ydczid	137	24	,	,	,
cord-253295-82ydczid	137	25	glycogen	glycogen	NN
cord-253295-82ydczid	137	26	/	/	SYM
cord-253295-82ydczid	137	27	mucin	mucin	NN
cord-253295-82ydczid	137	28	(	(	-LRB-
cord-253295-82ydczid	137	29	periodic	periodic	JJ
cord-253295-82ydczid	137	30	acid	acid	NN
cord-253295-82ydczid	137	31	-	-	HYPH
cord-253295-82ydczid	137	32	Schiff	Schiff	NNP
cord-253295-82ydczid	137	33	,	,	,
cord-253295-82ydczid	137	34	PAS	PAS	NNP
cord-253295-82ydczid	137	35	)	)	-RRB-
cord-253295-82ydczid	137	36	,	,	,
cord-253295-82ydczid	137	37	mucin	mucin	NN
cord-253295-82ydczid	137	38	(	(	-LRB-
cord-253295-82ydczid	137	39	PAS	pas	FW
cord-253295-82ydczid	137	40	diastase	diastase	NN
cord-253295-82ydczid	137	41	,	,	,
cord-253295-82ydczid	137	42	mucicarmine	mucicarmine	NN
cord-253295-82ydczid	137	43	,	,	,
cord-253295-82ydczid	137	44	alcian	alcian	NNP
cord-253295-82ydczid	137	45	blue	blue	NNP
cord-253295-82ydczid	137	46	)	)	-RRB-
cord-253295-82ydczid	137	47	,	,	,
cord-253295-82ydczid	137	48	fungi	fungus	NNS
cord-253295-82ydczid	137	49	(	(	-LRB-
cord-253295-82ydczid	137	50	Gemori	Gemori	NNP
cord-253295-82ydczid	137	51	methenamine	methenamine	NN
cord-253295-82ydczid	137	52	silver	silver	NN
cord-253295-82ydczid	137	53	,	,	,
cord-253295-82ydczid	137	54	GMS	GMS	NNP
cord-253295-82ydczid	137	55	)	)	-RRB-
cord-253295-82ydczid	137	56	,	,	,
cord-253295-82ydczid	137	57	mycobacteria	mycobacterium	NNS
cord-253295-82ydczid	137	58	(	(	-LRB-
cord-253295-82ydczid	137	59	Ziehl	Ziehl	NNP
cord-253295-82ydczid	137	60	-	-	HYPH
cord-253295-82ydczid	137	61	Neelsen	Neelsen	NNP
cord-253295-82ydczid	137	62	,	,	,
cord-253295-82ydczid	137	63	Fite	Fite	NNP
cord-253295-82ydczid	137	64	)	)	-RRB-
cord-253295-82ydczid	137	65	,	,	,
cord-253295-82ydczid	137	66	and	and	CC
cord-253295-82ydczid	137	67	bacteria	bacteria	NNS
cord-253295-82ydczid	137	68	(	(	-LRB-
cord-253295-82ydczid	137	69	Gram	Gram	NNP
cord-253295-82ydczid	137	70	,	,	,
cord-253295-82ydczid	137	71	Warthin	Warthin	NNP
cord-253295-82ydczid	137	72	-	-	HYPH
cord-253295-82ydczid	137	73	Starry	Starry	NNP
cord-253295-82ydczid	137	74	)	)	-RRB-
cord-253295-82ydczid	137	75	.	.	.
cord-253295-82ydczid	138	1	Each	each	DT
cord-253295-82ydczid	138	2	of	of	IN
cord-253295-82ydczid	138	3	these	these	DT
cord-253295-82ydczid	138	4	stains	stain	NNS
cord-253295-82ydczid	138	5	is	be	VBZ
cord-253295-82ydczid	138	6	inexpensive	inexpensive	JJ
cord-253295-82ydczid	138	7	(	(	-LRB-
cord-253295-82ydczid	138	8	$	$	$
cord-253295-82ydczid	138	9	10À$50	10à$50	CD
cord-253295-82ydczid	138	10	)	)	-RRB-
cord-253295-82ydczid	138	11	,	,	,
cord-253295-82ydczid	138	12	fast	fast	JJ
cord-253295-82ydczid	138	13	(	(	-LRB-
cord-253295-82ydczid	138	14	minutes	minute	NNS
cord-253295-82ydczid	138	15	to	to	IN
cord-253295-82ydczid	138	16	hours	hour	NNS
cord-253295-82ydczid	138	17	)	)	-RRB-
cord-253295-82ydczid	138	18	,	,	,
cord-253295-82ydczid	138	19	and	and	CC
cord-253295-82ydczid	138	20	automatable	automatable	JJ
cord-253295-82ydczid	138	21	,	,	,
cord-253295-82ydczid	138	22	making	make	VBG
cord-253295-82ydczid	138	23	them	-PRON-	PRP
cord-253295-82ydczid	138	24	extremely	extremely	RB
cord-253295-82ydczid	138	25	valuable	valuable	JJ
cord-253295-82ydczid	138	26	for	for	IN
cord-253295-82ydczid	138	27	service	service	NN
cord-253295-82ydczid	138	28	diagnostic	diagnostic	JJ
cord-253295-82ydczid	138	29	pathology	pathology	NN
cord-253295-82ydczid	138	30	use	use	NN
cord-253295-82ydczid	138	31	.	.	.
cord-253295-82ydczid	139	1	Light	light	JJ
cord-253295-82ydczid	139	2	microscopy	microscopy	NN
cord-253295-82ydczid	139	3	lens	lens	NN
cord-253295-82ydczid	139	4	technology	technology	NN
cord-253295-82ydczid	139	5	matured	mature	VBN
cord-253295-82ydczid	139	6	during	during	IN
cord-253295-82ydczid	139	7	the	the	DT
cord-253295-82ydczid	139	8	last	last	JJ
cord-253295-82ydczid	139	9	half	half	NN
cord-253295-82ydczid	139	10	of	of	IN
cord-253295-82ydczid	139	11	the	the	DT
cord-253295-82ydczid	139	12	19th	19th	JJ
cord-253295-82ydczid	139	13	century	century	NN
cord-253295-82ydczid	139	14	.	.	.
cord-253295-82ydczid	140	1	Critical	Critical	NNP
cord-253295-82ydczid	140	2	were	be	VBD
cord-253295-82ydczid	140	3	Abbe	Abbe	NNP
cord-253295-82ydczid	140	4	's	's	POS
cord-253295-82ydczid	140	5	introductions	introduction	NNS
cord-253295-82ydczid	140	6	of	of	IN
cord-253295-82ydczid	140	7	the	the	DT
cord-253295-82ydczid	140	8	apochromatic	apochromatic	JJ
cord-253295-82ydczid	140	9	lens	lens	NN
cord-253295-82ydczid	140	10	system	system	NN
cord-253295-82ydczid	140	11	to	to	TO
cord-253295-82ydczid	140	12	eliminate	eliminate	VB
cord-253295-82ydczid	140	13	chromatic	chromatic	JJ
cord-253295-82ydczid	140	14	aberration	aberration	NN
cord-253295-82ydczid	140	15	(	(	-LRB-
cord-253295-82ydczid	140	16	different	different	JJ
cord-253295-82ydczid	140	17	focal	focal	JJ
cord-253295-82ydczid	140	18	lengths	length	NNS
cord-253295-82ydczid	140	19	for	for	IN
cord-253295-82ydczid	140	20	different	different	JJ
cord-253295-82ydczid	140	21	wavelengths	wavelength	NNS
cord-253295-82ydczid	140	22	of	of	IN
cord-253295-82ydczid	140	23	visible	visible	JJ
cord-253295-82ydczid	140	24	light	light	NN
cord-253295-82ydczid	140	25	)	)	-RRB-
cord-253295-82ydczid	140	26	in	in	IN
cord-253295-82ydczid	140	27	1868	1868	CD
cord-253295-82ydczid	140	28	,	,	,
cord-253295-82ydczid	140	29	a	a	DT
cord-253295-82ydczid	140	30	novel	novel	JJ
cord-253295-82ydczid	140	31	condenser	condenser	NN
cord-253295-82ydczid	140	32	for	for	IN
cord-253295-82ydczid	140	33	compound	compound	NN
cord-253295-82ydczid	140	34	microscopes	microscope	NNS
cord-253295-82ydczid	140	35	(	(	-LRB-
cord-253295-82ydczid	140	36	to	to	TO
cord-253295-82ydczid	140	37	provide	provide	VB
cord-253295-82ydczid	140	38	better	well	JJR
cord-253295-82ydczid	140	39	illumination	illumination	NN
cord-253295-82ydczid	140	40	at	at	IN
cord-253295-82ydczid	140	41	high	high	JJ
cord-253295-82ydczid	140	42	magnification	magnification	NN
cord-253295-82ydczid	140	43	)	)	-RRB-
cord-253295-82ydczid	140	44	in	in	IN
cord-253295-82ydczid	140	45	1870	1870	CD
cord-253295-82ydczid	140	46	,	,	,
cord-253295-82ydczid	140	47	and	and	CC
cord-253295-82ydczid	140	48	an	an	DT
cord-253295-82ydczid	140	49	oil	oil	NN
cord-253295-82ydczid	140	50	immersion	immersion	NN
cord-253295-82ydczid	140	51	lens	lens	NN
cord-253295-82ydczid	140	52	in	in	IN
cord-253295-82ydczid	140	53	1878	1878	CD
cord-253295-82ydczid	140	54	.	.	.
cord-253295-82ydczid	141	1	By	by	IN
cord-253295-82ydczid	141	2	1900	1900	CD
cord-253295-82ydczid	141	3	,	,	,
cord-253295-82ydczid	141	4	maturation	maturation	NN
cord-253295-82ydczid	141	5	of	of	IN
cord-253295-82ydczid	141	6	tissue	tissue	NN
cord-253295-82ydczid	141	7	fixation	fixation	NN
cord-253295-82ydczid	141	8	chemistry	chemistry	NN
cord-253295-82ydczid	141	9	,	,	,
cord-253295-82ydczid	141	10	histochemical	histochemical	JJ
cord-253295-82ydczid	141	11	stain	stain	NN
cord-253295-82ydczid	141	12	protocols	protocol	NNS
cord-253295-82ydczid	141	13	,	,	,
cord-253295-82ydczid	141	14	and	and	CC
cord-253295-82ydczid	141	15	light	light	JJ
cord-253295-82ydczid	141	16	microscope	microscope	NN
cord-253295-82ydczid	141	17	technology	technology	NN
cord-253295-82ydczid	141	18	had	have	VBD
cord-253295-82ydczid	141	19	evolved	evolve	VBN
cord-253295-82ydczid	141	20	into	into	IN
cord-253295-82ydczid	141	21	the	the	DT
cord-253295-82ydczid	141	22	workhorse	workhorse	JJ
cord-253295-82ydczid	141	23	technique	technique	NN
cord-253295-82ydczid	141	24	for	for	IN
cord-253295-82ydczid	141	25	evaluation	evaluation	NN
cord-253295-82ydczid	141	26	of	of	IN
cord-253295-82ydczid	141	27	morphologic	morphologic	JJ
cord-253295-82ydczid	141	28	abnormalities	abnormality	NNS
cord-253295-82ydczid	141	29	in	in	IN
cord-253295-82ydczid	141	30	tissue	tissue	NN
cord-253295-82ydczid	141	31	examination	examination	NN
cord-253295-82ydczid	141	32	in	in	IN
cord-253295-82ydczid	141	33	anatomic	anatomic	JJ
cord-253295-82ydczid	141	34	pathology	pathology	NN
cord-253295-82ydczid	141	35	labs	lab	NNS
cord-253295-82ydczid	141	36	,	,	,
cord-253295-82ydczid	141	37	and	and	CC
cord-253295-82ydczid	141	38	for	for	IN
cord-253295-82ydczid	141	39	the	the	DT
cord-253295-82ydczid	141	40	evaluation	evaluation	NN
cord-253295-82ydczid	141	41	of	of	IN
cord-253295-82ydczid	141	42	morphologic	morphologic	JJ
cord-253295-82ydczid	141	43	features	feature	NNS
cord-253295-82ydczid	141	44	of	of	IN
cord-253295-82ydczid	141	45	microorganisms	microorganism	NNS
cord-253295-82ydczid	141	46	in	in	IN
cord-253295-82ydczid	141	47	microbiology	microbiology	NN
cord-253295-82ydczid	141	48	labs	lab	NNS
cord-253295-82ydczid	141	49	.	.	.
cord-253295-82ydczid	142	1	The	the	DT
cord-253295-82ydczid	142	2	scope	scope	NN
cord-253295-82ydczid	142	3	of	of	IN
cord-253295-82ydczid	142	4	this	this	DT
cord-253295-82ydczid	142	5	chapter	chapter	NN
cord-253295-82ydczid	142	6	is	be	VBZ
cord-253295-82ydczid	142	7	limited	limit	VBN
cord-253295-82ydczid	142	8	to	to	IN
cord-253295-82ydczid	142	9	pathology	pathology	NN
cord-253295-82ydczid	142	10	,	,	,
cord-253295-82ydczid	142	11	but	but	CC
cord-253295-82ydczid	142	12	it	-PRON-	PRP
cord-253295-82ydczid	142	13	should	should	MD
cord-253295-82ydczid	142	14	be	be	VB
cord-253295-82ydczid	142	15	clear	clear	JJ
cord-253295-82ydczid	142	16	to	to	IN
cord-253295-82ydczid	142	17	the	the	DT
cord-253295-82ydczid	142	18	reader	reader	NN
cord-253295-82ydczid	142	19	that	that	IN
cord-253295-82ydczid	142	20	the	the	DT
cord-253295-82ydczid	142	21	momentous	momentous	JJ
cord-253295-82ydczid	142	22	discoveries	discovery	NNS
cord-253295-82ydczid	142	23	of	of	IN
cord-253295-82ydczid	142	24	deep	deep	JJ
cord-253295-82ydczid	142	25	general	general	JJ
cord-253295-82ydczid	142	26	anesthetics	anesthetic	NNS
cord-253295-82ydczid	142	27	(	(	-LRB-
cord-253295-82ydczid	142	28	Long	long	RB
cord-253295-82ydczid	142	29	,	,	,
cord-253295-82ydczid	142	30	1841	1841	CD
cord-253295-82ydczid	142	31	;	;	:
cord-253295-82ydczid	142	32	Morton	Morton	NNP
cord-253295-82ydczid	142	33	,	,	,
cord-253295-82ydczid	142	34	1846	1846	CD
cord-253295-82ydczid	142	35	)	)	-RRB-
cord-253295-82ydczid	142	36	,	,	,
cord-253295-82ydczid	142	37	commercial	commercial	JJ
cord-253295-82ydczid	142	38	electricity	electricity	NN
cord-253295-82ydczid	142	39	(	(	-LRB-
cord-253295-82ydczid	142	40	Edison	Edison	NNP
cord-253295-82ydczid	142	41	,	,	,
cord-253295-82ydczid	142	42	1882	1882	CD
cord-253295-82ydczid	142	43	)	)	-RRB-
cord-253295-82ydczid	142	44	,	,	,
cord-253295-82ydczid	142	45	and	and	CC
cord-253295-82ydczid	142	46	radiography	radiography	NN
cord-253295-82ydczid	142	47	(	(	-LRB-
cord-253295-82ydczid	142	48	Roentgen	Roentgen	NNP
cord-253295-82ydczid	142	49	,	,	,
cord-253295-82ydczid	142	50	1895	1895	CD
cord-253295-82ydczid	142	51	)	)	-RRB-
cord-253295-82ydczid	142	52	also	also	RB
cord-253295-82ydczid	142	53	contributed	contribute	VBD
cord-253295-82ydczid	142	54	to	to	IN
cord-253295-82ydczid	142	55	the	the	DT
cord-253295-82ydczid	142	56	development	development	NN
cord-253295-82ydczid	142	57	of	of	IN
cord-253295-82ydczid	142	58	the	the	DT
cord-253295-82ydczid	142	59	modern	modern	JJ
cord-253295-82ydczid	142	60	medical	medical	JJ
cord-253295-82ydczid	142	61	specialties	specialty	NNS
cord-253295-82ydczid	142	62	of	of	IN
cord-253295-82ydczid	142	63	diagnostic	diagnostic	JJ
cord-253295-82ydczid	142	64	pathology	pathology	NN
cord-253295-82ydczid	142	65	and	and	CC
cord-253295-82ydczid	142	66	laboratory	laboratory	NN
cord-253295-82ydczid	142	67	medicine	medicine	NN
cord-253295-82ydczid	142	68	.	.	.
cord-253295-82ydczid	143	1	The	the	DT
cord-253295-82ydczid	143	2	development	development	NN
cord-253295-82ydczid	143	3	of	of	IN
cord-253295-82ydczid	143	4	antisera	antisera	NN
cord-253295-82ydczid	143	5	in	in	IN
cord-253295-82ydczid	143	6	the	the	DT
cord-253295-82ydczid	143	7	20th	20th	JJ
cord-253295-82ydczid	143	8	century	century	NN
cord-253295-82ydczid	143	9	for	for	IN
cord-253295-82ydczid	143	10	therapeutic	therapeutic	JJ
cord-253295-82ydczid	143	11	purposes	purpose	NNS
cord-253295-82ydczid	143	12	(	(	-LRB-
cord-253295-82ydczid	143	13	for	for	IN
cord-253295-82ydczid	143	14	instance	instance	NN
cord-253295-82ydczid	143	15	,	,	,
cord-253295-82ydczid	143	16	treatment	treatment	NN
cord-253295-82ydczid	143	17	of	of	IN
cord-253295-82ydczid	143	18	diptheria	diptheria	NN
cord-253295-82ydczid	143	19	)	)	-RRB-
cord-253295-82ydczid	143	20	led	lead	VBD
cord-253295-82ydczid	143	21	to	to	IN
cord-253295-82ydczid	143	22	progressive	progressive	JJ
cord-253295-82ydczid	143	23	understanding	understanding	NN
cord-253295-82ydczid	143	24	of	of	IN
cord-253295-82ydczid	143	25	the	the	DT
cord-253295-82ydczid	143	26	antibody	antibody	NN
cord-253295-82ydczid	143	27	,	,	,
cord-253295-82ydczid	143	28	the	the	DT
cord-253295-82ydczid	143	29	efferent	efferent	JJ
cord-253295-82ydczid	143	30	arm	arm	NN
cord-253295-82ydczid	143	31	of	of	IN
cord-253295-82ydczid	143	32	the	the	DT
cord-253295-82ydczid	143	33	humoral	humoral	JJ
cord-253295-82ydczid	143	34	immune	immune	JJ
cord-253295-82ydczid	143	35	response	response	NN
cord-253295-82ydczid	143	36	.	.	.
cord-253295-82ydczid	144	1	Similarly	similarly	RB
cord-253295-82ydczid	144	2	,	,	,
cord-253295-82ydczid	144	3	tissue	tissue	NN
cord-253295-82ydczid	144	4	transplantation	transplantation	NN
cord-253295-82ydczid	144	5	experiments	experiment	NNS
cord-253295-82ydczid	144	6	led	lead	VBD
cord-253295-82ydczid	144	7	to	to	IN
cord-253295-82ydczid	144	8	the	the	DT
cord-253295-82ydczid	144	9	recognition	recognition	NN
cord-253295-82ydczid	144	10	of	of	IN
cord-253295-82ydczid	144	11	cellular	cellular	JJ
cord-253295-82ydczid	144	12	rejection	rejection	NN
cord-253295-82ydczid	144	13	due	due	IN
cord-253295-82ydczid	144	14	to	to	IN
cord-253295-82ydczid	144	15	thymus	thymus	NN
cord-253295-82ydczid	144	16	-	-	HYPH
cord-253295-82ydczid	144	17	derived	derive	VBN
cord-253295-82ydczid	144	18	T	t	NN
cord-253295-82ydczid	144	19	-	-	HYPH
cord-253295-82ydczid	144	20	cells	cell	NNS
cord-253295-82ydczid	144	21	.	.	.
cord-253295-82ydczid	145	1	Antibodies	antibody	NNS
cord-253295-82ydczid	145	2	and	and	CC
cord-253295-82ydczid	145	3	T	t	NN
cord-253295-82ydczid	145	4	-	-	HYPH
cord-253295-82ydczid	145	5	cells	cell	NNS
cord-253295-82ydczid	145	6	cooperate	cooperate	VBP
cord-253295-82ydczid	145	7	to	to	TO
cord-253295-82ydczid	145	8	react	react	VB
cord-253295-82ydczid	145	9	to	to	IN
cord-253295-82ydczid	145	10	foreign	foreign	JJ
cord-253295-82ydczid	145	11	(	(	-LRB-
cord-253295-82ydczid	145	12	non	non	JJ
cord-253295-82ydczid	145	13	-	-	JJ
cord-253295-82ydczid	145	14	self	self	JJ
cord-253295-82ydczid	145	15	)	)	-RRB-
cord-253295-82ydczid	145	16	molecules	molecule	NNS
cord-253295-82ydczid	145	17	,	,	,
cord-253295-82ydczid	145	18	common	common	JJ
cord-253295-82ydczid	145	19	examples	example	NNS
cord-253295-82ydczid	145	20	being	be	VBG
cord-253295-82ydczid	145	21	allergic	allergic	JJ
cord-253295-82ydczid	145	22	responses	response	NNS
cord-253295-82ydczid	145	23	,	,	,
cord-253295-82ydczid	145	24	viral	viral	JJ
cord-253295-82ydczid	145	25	infections	infection	NNS
cord-253295-82ydczid	145	26	,	,	,
cord-253295-82ydczid	145	27	and	and	CC
cord-253295-82ydczid	145	28	organ	organ	NN
cord-253295-82ydczid	145	29	transplants	transplant	NNS
cord-253295-82ydczid	145	30	.	.	.
cord-253295-82ydczid	146	1	Antibodies	antibody	NNS
cord-253295-82ydczid	146	2	were	be	VBD
cord-253295-82ydczid	146	3	found	find	VBN
cord-253295-82ydczid	146	4	to	to	TO
cord-253295-82ydczid	146	5	be	be	VB
cord-253295-82ydczid	146	6	made	make	VBN
cord-253295-82ydczid	146	7	by	by	IN
cord-253295-82ydczid	146	8	B	b	NN
cord-253295-82ydczid	146	9	-	-	HYPH
cord-253295-82ydczid	146	10	cells	cell	NNS
cord-253295-82ydczid	146	11	and	and	CC
cord-253295-82ydczid	146	12	plasma	plasma	NN
cord-253295-82ydczid	146	13	cells	cell	NNS
cord-253295-82ydczid	146	14	,	,	,
cord-253295-82ydczid	146	15	and	and	CC
cord-253295-82ydczid	146	16	were	be	VBD
cord-253295-82ydczid	146	17	found	find	VBN
cord-253295-82ydczid	146	18	to	to	TO
cord-253295-82ydczid	146	19	be	be	VB
cord-253295-82ydczid	146	20	exquisitely	exquisitely	RB
cord-253295-82ydczid	146	21	specific	specific	JJ
cord-253295-82ydczid	146	22	for	for	IN
cord-253295-82ydczid	146	23	binding	bind	VBG
cord-253295-82ydczid	146	24	to	to	IN
cord-253295-82ydczid	146	25	their	-PRON-	PRP$
cord-253295-82ydczid	146	26	particular	particular	JJ
cord-253295-82ydczid	146	27	antigens	antigen	NNS
cord-253295-82ydczid	146	28	(	(	-LRB-
cord-253295-82ydczid	146	29	ligands	ligand	NNS
cord-253295-82ydczid	146	30	)	)	-RRB-
cord-253295-82ydczid	146	31	either	either	CC
cord-253295-82ydczid	146	32	in	in	IN
cord-253295-82ydczid	146	33	solid	solid	JJ
cord-253295-82ydczid	146	34	phase	phase	NN
cord-253295-82ydczid	146	35	or	or	CC
cord-253295-82ydczid	146	36	in	in	IN
cord-253295-82ydczid	146	37	solution	solution	NN
cord-253295-82ydczid	146	38	.	.	.
cord-253295-82ydczid	147	1	The	the	DT
cord-253295-82ydczid	147	2	analogous	analogous	JJ
cord-253295-82ydczid	147	3	T	t	NN
cord-253295-82ydczid	147	4	-	-	HYPH
cord-253295-82ydczid	147	5	cell	cell	NN
cord-253295-82ydczid	147	6	receptor	receptor	NN
cord-253295-82ydczid	147	7	(	(	-LRB-
cord-253295-82ydczid	147	8	TCR	TCR	NNP
cord-253295-82ydczid	147	9	)	)	-RRB-
cord-253295-82ydczid	147	10	recognizes	recognize	VBZ
cord-253295-82ydczid	147	11	a	a	DT
cord-253295-82ydczid	147	12	ligand	ligand	NN
cord-253295-82ydczid	147	13	made	make	VBN
cord-253295-82ydczid	147	14	up	up	RP
cord-253295-82ydczid	147	15	of	of	IN
cord-253295-82ydczid	147	16	a	a	DT
cord-253295-82ydczid	147	17	15À20mer	15à20mer	CD
cord-253295-82ydczid	147	18	peptide	peptide	NN
cord-253295-82ydczid	147	19	presented	present	VBN
cord-253295-82ydczid	147	20	by	by	IN
cord-253295-82ydczid	147	21	self	self	NN
cord-253295-82ydczid	147	22	MHC	MHC	NNP
cord-253295-82ydczid	147	23	(	(	-LRB-
cord-253295-82ydczid	147	24	HLA	HLA	NNP
cord-253295-82ydczid	147	25	in	in	IN
cord-253295-82ydczid	147	26	human	human	NN
cord-253295-82ydczid	147	27	)	)	-RRB-
cord-253295-82ydczid	147	28	molecules	molecule	NNS
cord-253295-82ydczid	147	29	on	on	IN
cord-253295-82ydczid	147	30	the	the	DT
cord-253295-82ydczid	147	31	surface	surface	NN
cord-253295-82ydczid	147	32	of	of	IN
cord-253295-82ydczid	147	33	antigen	antigen	NN
cord-253295-82ydczid	147	34	-	-	HYPH
cord-253295-82ydczid	147	35	presenting	present	VBG
cord-253295-82ydczid	147	36	cells	cell	NNS
cord-253295-82ydczid	147	37	(	(	-LRB-
cord-253295-82ydczid	147	38	macrophages	macrophage	NNS
cord-253295-82ydczid	147	39	,	,	,
cord-253295-82ydczid	147	40	dendritic	dendritic	JJ
cord-253295-82ydczid	147	41	cells	cell	NNS
cord-253295-82ydczid	147	42	,	,	,
cord-253295-82ydczid	147	43	activated	activate	VBN
cord-253295-82ydczid	147	44	B	b	NN
cord-253295-82ydczid	147	45	-	-	HYPH
cord-253295-82ydczid	147	46	cells	cell	NNS
cord-253295-82ydczid	147	47	)	)	-RRB-
cord-253295-82ydczid	147	48	.	.	.
cord-253295-82ydczid	148	1	B	b	NN
cord-253295-82ydczid	148	2	-	-	HYPH
cord-253295-82ydczid	148	3	cell	cell	NN
cord-253295-82ydczid	148	4	and	and	CC
cord-253295-82ydczid	148	5	T	t	NN
cord-253295-82ydczid	148	6	-	-	HYPH
cord-253295-82ydczid	148	7	cells	cell	NNS
cord-253295-82ydczid	148	8	activate	activate	VBP
cord-253295-82ydczid	148	9	and	and	CC
cord-253295-82ydczid	148	10	proliferate	proliferate	VBP
cord-253295-82ydczid	148	11	when	when	WRB
cord-253295-82ydczid	148	12	exposed	expose	VBN
cord-253295-82ydczid	148	13	to	to	IN
cord-253295-82ydczid	148	14	non	non	JJ
cord-253295-82ydczid	148	15	-	-	JJ
cord-253295-82ydczid	148	16	self	self	JJ
cord-253295-82ydczid	148	17	proteins	protein	NNS
cord-253295-82ydczid	148	18	,	,	,
cord-253295-82ydczid	148	19	but	but	CC
cord-253295-82ydczid	148	20	not	not	RB
cord-253295-82ydczid	148	21	to	to	TO
cord-253295-82ydczid	148	22	self	self	NN
cord-253295-82ydczid	148	23	proteins	protein	NNS
cord-253295-82ydczid	148	24	,	,	,
cord-253295-82ydczid	148	25	attesting	attest	VBG
cord-253295-82ydczid	148	26	to	to	IN
cord-253295-82ydczid	148	27	tolerance	tolerance	NN
cord-253295-82ydczid	148	28	to	to	IN
cord-253295-82ydczid	148	29	self	self	NN
cord-253295-82ydczid	148	30	.	.	.
cord-253295-82ydczid	149	1	When	when	WRB
cord-253295-82ydczid	149	2	B	b	NN
cord-253295-82ydczid	149	3	-	-	HYPH
cord-253295-82ydczid	149	4	cell	cell	NN
cord-253295-82ydczid	149	5	and	and	CC
cord-253295-82ydczid	149	6	T	t	NN
cord-253295-82ydczid	149	7	-	-	HYPH
cord-253295-82ydczid	149	8	cell	cell	NN
cord-253295-82ydczid	149	9	self	self	NN
cord-253295-82ydczid	149	10	-	-	HYPH
cord-253295-82ydczid	149	11	tolerance	tolerance	NN
cord-253295-82ydczid	149	12	breaks	break	VBZ
cord-253295-82ydczid	149	13	down	down	RP
cord-253295-82ydczid	149	14	,	,	,
cord-253295-82ydczid	149	15	autoimmune	autoimmune	JJ
cord-253295-82ydczid	149	16	diseases	disease	NNS
cord-253295-82ydczid	149	17	can	can	MD
cord-253295-82ydczid	149	18	result	result	VB
cord-253295-82ydczid	149	19	(	(	-LRB-
cord-253295-82ydczid	149	20	including	include	VBG
cord-253295-82ydczid	149	21	myasthenia	myasthenia	NN
cord-253295-82ydczid	149	22	gravis	gravis	NN
cord-253295-82ydczid	149	23	,	,	,
cord-253295-82ydczid	149	24	Grave	Grave	NNP
cord-253295-82ydczid	149	25	's	's	POS
cord-253295-82ydczid	149	26	disease	disease	NN
cord-253295-82ydczid	149	27	,	,	,
cord-253295-82ydczid	149	28	and	and	CC
cord-253295-82ydczid	149	29	lupus	lupus	NN
cord-253295-82ydczid	149	30	erythematosus	erythematosus	NN
cord-253295-82ydczid	149	31	)	)	-RRB-
cord-253295-82ydczid	149	32	.	.	.
cord-253295-82ydczid	150	1	Antibodies	antibody	NNS
cord-253295-82ydczid	150	2	(	(	-LRB-
cord-253295-82ydczid	150	3	immunoglobulins	immunoglobulin	NNS
cord-253295-82ydczid	150	4	)	)	-RRB-
cord-253295-82ydczid	150	5	were	be	VBD
cord-253295-82ydczid	150	6	found	find	VBN
cord-253295-82ydczid	150	7	to	to	TO
cord-253295-82ydczid	150	8	be	be	VB
cord-253295-82ydczid	150	9	heterodimers	heterodimer	NNS
cord-253295-82ydczid	150	10	of	of	IN
cord-253295-82ydczid	150	11	50	50	CD
cord-253295-82ydczid	150	12	kD	kd	JJ
cord-253295-82ydczid	150	13	heavy	heavy	JJ
cord-253295-82ydczid	150	14	chains	chain	NNS
cord-253295-82ydczid	150	15	and	and	CC
cord-253295-82ydczid	150	16	25	25	CD
cord-253295-82ydczid	150	17	kD	kd	JJ
cord-253295-82ydczid	150	18	light	light	JJ
cord-253295-82ydczid	150	19	chains	chain	NNS
cord-253295-82ydczid	150	20	,	,	,
cord-253295-82ydczid	150	21	folded	fold	VBN
cord-253295-82ydczid	150	22	together	together	RB
cord-253295-82ydczid	150	23	so	so	IN
cord-253295-82ydczid	150	24	that	that	IN
cord-253295-82ydczid	150	25	a	a	DT
cord-253295-82ydczid	150	26	highly	highly	RB
cord-253295-82ydczid	150	27	variable	variable	JJ
cord-253295-82ydczid	150	28	portion	portion	NN
cord-253295-82ydczid	150	29	defines	define	VBZ
cord-253295-82ydczid	150	30	the	the	DT
cord-253295-82ydczid	150	31	antigen	antigen	NN
cord-253295-82ydczid	150	32	-	-	HYPH
cord-253295-82ydczid	150	33	binding	bind	VBG
cord-253295-82ydczid	150	34	site	site	NN
cord-253295-82ydczid	150	35	,	,	,
cord-253295-82ydczid	150	36	and	and	CC
cord-253295-82ydczid	150	37	a	a	DT
cord-253295-82ydczid	150	38	constant	constant	JJ
cord-253295-82ydczid	150	39	portion	portion	NN
cord-253295-82ydczid	150	40	defines	define	VBZ
cord-253295-82ydczid	150	41	the	the	DT
cord-253295-82ydczid	150	42	isotype	isotype	NN
cord-253295-82ydczid	150	43	(	(	-LRB-
cord-253295-82ydczid	150	44	IgM	IgM	NNP
cord-253295-82ydczid	150	45	,	,	,
cord-253295-82ydczid	150	46	IgD	IgD	NNP
cord-253295-82ydczid	150	47	,	,	,
cord-253295-82ydczid	150	48	IgG	IgG	NNP
cord-253295-82ydczid	150	49	,	,	,
cord-253295-82ydczid	150	50	IgE	IgE	NNP
cord-253295-82ydczid	150	51	,	,	,
cord-253295-82ydczid	150	52	or	or	CC
cord-253295-82ydczid	150	53	IgA	IgA	NNP
cord-253295-82ydczid	150	54	)	)	-RRB-
cord-253295-82ydczid	150	55	.	.	.
cord-253295-82ydczid	151	1	Similarly	similarly	RB
cord-253295-82ydczid	151	2	,	,	,
cord-253295-82ydczid	151	3	T	t	NN
cord-253295-82ydczid	151	4	-	-	HYPH
cord-253295-82ydczid	151	5	cell	cell	NN
cord-253295-82ydczid	151	6	receptors	receptor	NNS
cord-253295-82ydczid	151	7	were	be	VBD
cord-253295-82ydczid	151	8	found	find	VBN
cord-253295-82ydczid	151	9	to	to	TO
cord-253295-82ydczid	151	10	be	be	VB
cord-253295-82ydczid	151	11	heterodimers	heterodimer	NNS
cord-253295-82ydczid	151	12	of	of	IN
cord-253295-82ydczid	151	13	immunoglobulinlike	immunoglobulinlike	JJ
cord-253295-82ydczid	151	14	molecules	molecule	NNS
cord-253295-82ydczid	151	15	with	with	IN
cord-253295-82ydczid	151	16	a	a	DT
cord-253295-82ydczid	151	17	highly	highly	RB
cord-253295-82ydczid	151	18	variable	variable	JJ
cord-253295-82ydczid	151	19	portion	portion	NN
cord-253295-82ydczid	151	20	for	for	IN
cord-253295-82ydczid	151	21	ligand	ligand	NN
cord-253295-82ydczid	151	22	binding	binding	NN
cord-253295-82ydczid	151	23	,	,	,
cord-253295-82ydczid	151	24	and	and	CC
cord-253295-82ydczid	151	25	a	a	DT
cord-253295-82ydczid	151	26	constant	constant	JJ
cord-253295-82ydczid	151	27	portion	portion	NN
cord-253295-82ydczid	151	28	,	,	,
cord-253295-82ydczid	151	29	but	but	CC
cord-253295-82ydczid	151	30	without	without	IN
cord-253295-82ydczid	151	31	different	different	JJ
cord-253295-82ydczid	151	32	isotypes	isotypes	NNP
cord-253295-82ydczid	151	33	.	.	.
cord-253295-82ydczid	152	1	The	the	DT
cord-253295-82ydczid	152	2	range	range	NN
cord-253295-82ydczid	152	3	of	of	IN
cord-253295-82ydczid	152	4	antigen	antigen	NN
cord-253295-82ydczid	152	5	-	-	HYPH
cord-253295-82ydczid	152	6	binding	bind	VBG
cord-253295-82ydczid	152	7	specificities	specificity	NNS
cord-253295-82ydczid	152	8	in	in	IN
cord-253295-82ydczid	152	9	a	a	DT
cord-253295-82ydczid	152	10	normal	normal	JJ
cord-253295-82ydczid	152	11	mammal	mammal	NN
cord-253295-82ydczid	152	12	is	be	VBZ
cord-253295-82ydczid	152	13	extensive	extensive	JJ
cord-253295-82ydczid	152	14	,	,	,
cord-253295-82ydczid	152	15	perhaps	perhaps	RB
cord-253295-82ydczid	152	16	infinite	infinite	JJ
cord-253295-82ydczid	152	17	,	,	,
cord-253295-82ydczid	152	18	subtracting	subtract	VBG
cord-253295-82ydczid	152	19	out	out	RP
cord-253295-82ydczid	152	20	only	only	RB
cord-253295-82ydczid	152	21	those	those	DT
cord-253295-82ydczid	152	22	self	self	NN
cord-253295-82ydczid	152	23	proteins	protein	NNS
cord-253295-82ydczid	152	24	to	to	TO
cord-253295-82ydczid	152	25	which	which	WDT
cord-253295-82ydczid	152	26	the	the	DT
cord-253295-82ydczid	152	27	animal	animal	NN
cord-253295-82ydczid	152	28	is	be	VBZ
cord-253295-82ydczid	152	29	tolerant	tolerant	JJ
cord-253295-82ydczid	152	30	.	.	.
cord-253295-82ydczid	153	1	The	the	DT
cord-253295-82ydczid	153	2	genes	gene	NNS
cord-253295-82ydczid	153	3	encoding	encode	VBG
cord-253295-82ydczid	153	4	immunoglobulins	immunoglobulin	NNS
cord-253295-82ydczid	153	5	and	and	CC
cord-253295-82ydczid	153	6	T	t	NN
cord-253295-82ydczid	153	7	-	-	HYPH
cord-253295-82ydczid	153	8	cell	cell	NN
cord-253295-82ydczid	153	9	receptors	receptor	NNS
cord-253295-82ydczid	153	10	were	be	VBD
cord-253295-82ydczid	153	11	sequenced	sequence	VBN
cord-253295-82ydczid	153	12	and	and	CC
cord-253295-82ydczid	153	13	,	,	,
cord-253295-82ydczid	153	14	surprisingly	surprisingly	RB
cord-253295-82ydczid	153	15	,	,	,
cord-253295-82ydczid	153	16	the	the	DT
cord-253295-82ydczid	153	17	extensive	extensive	JJ
cord-253295-82ydczid	153	18	variation	variation	NN
cord-253295-82ydczid	153	19	of	of	IN
cord-253295-82ydczid	153	20	specificities	specificity	NNS
cord-253295-82ydczid	153	21	was	be	VBD
cord-253295-82ydczid	153	22	due	due	JJ
cord-253295-82ydczid	153	23	to	to	IN
cord-253295-82ydczid	153	24	a	a	DT
cord-253295-82ydczid	153	25	unique	unique	JJ
cord-253295-82ydczid	153	26	system	system	NN
cord-253295-82ydczid	153	27	of	of	IN
cord-253295-82ydczid	153	28	gene	gene	NN
cord-253295-82ydczid	153	29	rearrangements	rearrangement	NNS
cord-253295-82ydczid	153	30	of	of	IN
cord-253295-82ydczid	153	31	polymorphic	polymorphic	JJ
cord-253295-82ydczid	153	32	V	v	NN
cord-253295-82ydczid	153	33	,	,	,
cord-253295-82ydczid	153	34	D	D	NNP
cord-253295-82ydczid	153	35	,	,	,
cord-253295-82ydczid	153	36	and	and	CC
cord-253295-82ydczid	153	37	J	J	NNP
cord-253295-82ydczid	153	38	gene	gene	NN
cord-253295-82ydczid	153	39	segments	segment	NNS
cord-253295-82ydczid	153	40	with	with	IN
cord-253295-82ydczid	153	41	random	random	JJ
cord-253295-82ydczid	153	42	nucleotide	nucleotide	JJ
cord-253295-82ydczid	153	43	addition	addition	NN
cord-253295-82ydczid	153	44	at	at	IN
cord-253295-82ydczid	153	45	the	the	DT
cord-253295-82ydczid	153	46	junctions	junction	NNS
cord-253295-82ydczid	153	47	.	.	.
cord-253295-82ydczid	154	1	This	this	DT
cord-253295-82ydczid	154	2	system	system	NN
cord-253295-82ydczid	154	3	allows	allow	VBZ
cord-253295-82ydczid	154	4	generation	generation	NN
cord-253295-82ydczid	154	5	of	of	IN
cord-253295-82ydczid	154	6	literally	literally	RB
cord-253295-82ydczid	154	7	billions	billion	NNS
cord-253295-82ydczid	154	8	of	of	IN
cord-253295-82ydczid	154	9	different	different	JJ
cord-253295-82ydczid	154	10	Ig	Ig	NNP
cord-253295-82ydczid	154	11	and	and	CC
cord-253295-82ydczid	154	12	TCR	TCR	NNP
cord-253295-82ydczid	154	13	binding	bind	VBG
cord-253295-82ydczid	154	14	specificities	specificity	NNS
cord-253295-82ydczid	154	15	.	.	.
cord-253295-82ydczid	155	1	Although	although	IN
cord-253295-82ydczid	155	2	the	the	DT
cord-253295-82ydczid	155	3	Ig	Ig	NNP
cord-253295-82ydczid	155	4	and	and	CC
cord-253295-82ydczid	155	5	TCR	TCR	NNP
cord-253295-82ydczid	155	6	molecules	molecule	NNS
cord-253295-82ydczid	155	7	define	define	VBP
cord-253295-82ydczid	155	8	the	the	DT
cord-253295-82ydczid	155	9	specificity	specificity	NN
cord-253295-82ydczid	155	10	of	of	IN
cord-253295-82ydczid	155	11	antigen	antigen	NN
cord-253295-82ydczid	155	12	(	(	-LRB-
cord-253295-82ydczid	155	13	ligand	ligand	NN
cord-253295-82ydczid	155	14	)	)	-RRB-
cord-253295-82ydczid	155	15	binding	binding	NN
cord-253295-82ydczid	155	16	,	,	,
cord-253295-82ydczid	155	17	we	-PRON-	PRP
cord-253295-82ydczid	155	18	now	now	RB
cord-253295-82ydczid	155	19	understand	understand	VBP
cord-253295-82ydczid	155	20	that	that	IN
cord-253295-82ydczid	155	21	the	the	DT
cord-253295-82ydczid	155	22	probability	probability	NN
cord-253295-82ydczid	155	23	of	of	IN
cord-253295-82ydczid	155	24	T	T	NNP
cord-253295-82ydczid	155	25	lymphocyte	lymphocyte	NN
cord-253295-82ydczid	155	26	activation	activation	NN
cord-253295-82ydczid	155	27	is	be	VBZ
cord-253295-82ydczid	155	28	adjustable	adjustable	JJ
cord-253295-82ydczid	155	29	,	,	,
cord-253295-82ydczid	155	30	based	base	VBN
cord-253295-82ydczid	155	31	on	on	IN
cord-253295-82ydczid	155	32	activating	activate	VBG
cord-253295-82ydczid	155	33	(	(	-LRB-
cord-253295-82ydczid	155	34	e.g.	e.g.	IN
cord-253295-82ydczid	155	35	CD28	CD28	NNP
cord-253295-82ydczid	155	36	:	:	:
cord-253295-82ydczid	155	37	B7	B7	NNP
cord-253295-82ydczid	155	38	)	)	-RRB-
cord-253295-82ydczid	155	39	or	or	CC
cord-253295-82ydczid	155	40	inhibitory	inhibitory	JJ
cord-253295-82ydczid	155	41	(	(	-LRB-
cord-253295-82ydczid	155	42	e.g.	e.g.	RB
cord-253295-82ydczid	156	1	PD-1	pd-1	NN
cord-253295-82ydczid	156	2	:	:	:
cord-253295-82ydczid	156	3	PD	PD	NNP
cord-253295-82ydczid	156	4	-	-	HYPH
cord-253295-82ydczid	156	5	L1	L1	NNP
cord-253295-82ydczid	156	6	)	)	-RRB-
cord-253295-82ydczid	156	7	receptor	receptor	NN
cord-253295-82ydczid	156	8	:	:	:
cord-253295-82ydczid	156	9	ligand	ligand	NN
cord-253295-82ydczid	156	10	interactions	interaction	NNS
cord-253295-82ydczid	156	11	.	.	.
cord-253295-82ydczid	157	1	Polyclonal	Polyclonal	NNP
cord-253295-82ydczid	157	2	antibodies	antibody	NNS
cord-253295-82ydczid	157	3	raised	raise	VBD
cord-253295-82ydczid	157	4	in	in	IN
cord-253295-82ydczid	157	5	other	other	JJ
cord-253295-82ydczid	157	6	species	specie	NNS
cord-253295-82ydczid	157	7	(	(	-LRB-
cord-253295-82ydczid	157	8	goat	goat	NN
cord-253295-82ydczid	157	9	,	,	,
cord-253295-82ydczid	157	10	mouse	mouse	NN
cord-253295-82ydczid	157	11	,	,	,
cord-253295-82ydczid	157	12	rabbit	rabbit	NN
cord-253295-82ydczid	157	13	)	)	-RRB-
cord-253295-82ydczid	157	14	against	against	IN
cord-253295-82ydczid	157	15	an	an	DT
cord-253295-82ydczid	157	16	antigen	antigen	NN
cord-253295-82ydczid	157	17	can	can	MD
cord-253295-82ydczid	157	18	be	be	VB
cord-253295-82ydczid	157	19	used	use	VBN
cord-253295-82ydczid	157	20	to	to	TO
cord-253295-82ydczid	157	21	detect	detect	VB
cord-253295-82ydczid	157	22	the	the	DT
cord-253295-82ydczid	157	23	antigen	antigen	NN
cord-253295-82ydczid	157	24	in	in	IN
cord-253295-82ydczid	157	25	diffusion	diffusion	NN
cord-253295-82ydczid	157	26	gels	gel	NNS
cord-253295-82ydczid	157	27	(	(	-LRB-
cord-253295-82ydczid	157	28	Ochterlony	Ochterlony	NNP
cord-253295-82ydczid	157	29	,	,	,
cord-253295-82ydczid	157	30	western	western	JJ
cord-253295-82ydczid	157	31	blot	blot	NN
cord-253295-82ydczid	157	32	)	)	-RRB-
cord-253295-82ydczid	157	33	,	,	,
cord-253295-82ydczid	157	34	in	in	IN
cord-253295-82ydczid	157	35	solution	solution	NN
cord-253295-82ydczid	157	36	(	(	-LRB-
cord-253295-82ydczid	157	37	ELISA	ELISA	NNP
cord-253295-82ydczid	157	38	)	)	-RRB-
cord-253295-82ydczid	157	39	,	,	,
cord-253295-82ydczid	157	40	and	and	CC
cord-253295-82ydczid	157	41	in	in	IN
cord-253295-82ydczid	157	42	tissue	tissue	NN
cord-253295-82ydczid	157	43	sections	section	NNS
cord-253295-82ydczid	157	44	.	.	.
cord-253295-82ydczid	158	1	Use	use	NN
cord-253295-82ydczid	158	2	of	of	IN
cord-253295-82ydczid	158	3	fluorescent	fluorescent	NN
cord-253295-82ydczid	158	4	-	-	HYPH
cord-253295-82ydczid	158	5	tagged	tag	VBN
cord-253295-82ydczid	158	6	antibodies	antibody	NNS
cord-253295-82ydczid	158	7	for	for	IN
cord-253295-82ydczid	158	8	frozen	frozen	JJ
cord-253295-82ydczid	158	9	section	section	NN
cord-253295-82ydczid	158	10	immunohistochemistry	immunohistochemistry	NN
cord-253295-82ydczid	158	11	was	be	VBD
cord-253295-82ydczid	158	12	developed	develop	VBN
cord-253295-82ydczid	158	13	first	first	RB
cord-253295-82ydczid	158	14	,	,	,
cord-253295-82ydczid	158	15	and	and	CC
cord-253295-82ydczid	158	16	immunofluorescence	immunofluorescence	NN
cord-253295-82ydczid	158	17	(	(	-LRB-
cord-253295-82ydczid	158	18	IF	if	NN
cord-253295-82ydczid	158	19	)	)	-RRB-
cord-253295-82ydczid	158	20	is	be	VBZ
cord-253295-82ydczid	158	21	still	still	RB
cord-253295-82ydczid	158	22	routinely	routinely	RB
cord-253295-82ydczid	158	23	used	use	VBN
cord-253295-82ydczid	158	24	in	in	IN
cord-253295-82ydczid	158	25	renal	renal	JJ
cord-253295-82ydczid	158	26	pathology	pathology	NN
cord-253295-82ydczid	158	27	and	and	CC
cord-253295-82ydczid	158	28	dermatopathology	dermatopathology	NN
cord-253295-82ydczid	158	29	.	.	.
cord-253295-82ydczid	159	1	Peroxidase	peroxidase	NN
cord-253295-82ydczid	159	2	-	-	HYPH
cord-253295-82ydczid	159	3	tagged	tag	VBN
cord-253295-82ydczid	159	4	secondary	secondary	JJ
cord-253295-82ydczid	159	5	antibodies	antibody	NNS
cord-253295-82ydczid	159	6	and	and	CC
cord-253295-82ydczid	159	7	DAB	dab	NN
cord-253295-82ydczid	159	8	chemistry	chemistry	NN
cord-253295-82ydczid	159	9	were	be	VBD
cord-253295-82ydczid	159	10	developed	develop	VBN
cord-253295-82ydczid	159	11	to	to	TO
cord-253295-82ydczid	159	12	generate	generate	VB
cord-253295-82ydczid	159	13	a	a	DT
cord-253295-82ydczid	159	14	stable	stable	JJ
cord-253295-82ydczid	159	15	chromogen	chromogen	NN
cord-253295-82ydczid	159	16	in	in	IN
cord-253295-82ydczid	159	17	the	the	DT
cord-253295-82ydczid	159	18	tissue	tissue	NN
cord-253295-82ydczid	159	19	,	,	,
cord-253295-82ydczid	159	20	and	and	CC
cord-253295-82ydczid	159	21	this	this	DT
cord-253295-82ydczid	159	22	is	be	VBZ
cord-253295-82ydczid	159	23	now	now	RB
cord-253295-82ydczid	159	24	the	the	DT
cord-253295-82ydczid	159	25	primary	primary	JJ
cord-253295-82ydczid	159	26	method	method	NN
cord-253295-82ydczid	159	27	for	for	IN
cord-253295-82ydczid	159	28	detecting	detect	VBG
cord-253295-82ydczid	159	29	antigens	antigen	NNS
cord-253295-82ydczid	159	30	in	in	IN
cord-253295-82ydczid	159	31	formalin	formalin	NN
cord-253295-82ydczid	159	32	-	-	HYPH
cord-253295-82ydczid	159	33	fixed	fix	VBN
cord-253295-82ydczid	159	34	tissue	tissue	NN
cord-253295-82ydczid	159	35	sections	section	NNS
cord-253295-82ydczid	159	36	.	.	.
cord-253295-82ydczid	160	1	Improved	improve	VBN
cord-253295-82ydczid	160	2	antibody	antibody	NN
cord-253295-82ydczid	160	3	binding	bind	VBG
cord-253295-82ydczid	160	4	specificity	specificity	NN
cord-253295-82ydczid	160	5	and	and	CC
cord-253295-82ydczid	160	6	industrial	industrial	JJ
cord-253295-82ydczid	160	7	production	production	NN
cord-253295-82ydczid	160	8	required	require	VBD
cord-253295-82ydczid	160	9	monoclonal	monoclonal	JJ
cord-253295-82ydczid	160	10	antibodies	antibody	NNS
cord-253295-82ydczid	160	11	,	,	,
cord-253295-82ydczid	160	12	which	which	WDT
cord-253295-82ydczid	160	13	in	in	IN
cord-253295-82ydczid	160	14	turn	turn	NN
cord-253295-82ydczid	160	15	required	require	VBD
cord-253295-82ydczid	160	16	the	the	DT
cord-253295-82ydczid	160	17	development	development	NN
cord-253295-82ydczid	160	18	of	of	IN
cord-253295-82ydczid	160	19	mouse	mouse	NN
cord-253295-82ydczid	160	20	plasmacytomas	plasmacytomas	NNP
cord-253295-82ydczid	160	21	/	/	SYM
cord-253295-82ydczid	160	22	myelomas	myeloma	NNS
cord-253295-82ydczid	160	23	and	and	CC
cord-253295-82ydczid	160	24	cell	cell	NN
cord-253295-82ydczid	160	25	fusion	fusion	NN
cord-253295-82ydczid	160	26	protocols	protocol	NNS
cord-253295-82ydczid	160	27	.	.	.
cord-253295-82ydczid	161	1	The	the	DT
cord-253295-82ydczid	161	2	net	net	JJ
cord-253295-82ydczid	161	3	result	result	NN
cord-253295-82ydczid	161	4	is	be	VBZ
cord-253295-82ydczid	161	5	that	that	IN
cord-253295-82ydczid	161	6	commercial	commercial	JJ
cord-253295-82ydczid	161	7	antibodies	antibody	NNS
cord-253295-82ydczid	161	8	are	be	VBP
cord-253295-82ydczid	161	9	now	now	RB
cord-253295-82ydczid	161	10	available	available	JJ
cord-253295-82ydczid	161	11	for	for	IN
cord-253295-82ydczid	161	12	antigens	antigen	NNS
cord-253295-82ydczid	161	13	of	of	IN
cord-253295-82ydczid	161	14	both	both	CC
cord-253295-82ydczid	161	15	clinical	clinical	JJ
cord-253295-82ydczid	161	16	and	and	CC
cord-253295-82ydczid	161	17	research	research	NN
cord-253295-82ydczid	161	18	interest	interest	NN
cord-253295-82ydczid	161	19	,	,	,
cord-253295-82ydczid	161	20	including	include	VBG
cord-253295-82ydczid	161	21	antibodies	antibody	NNS
cord-253295-82ydczid	161	22	specific	specific	JJ
cord-253295-82ydczid	161	23	enough	enough	RB
cord-253295-82ydczid	161	24	to	to	TO
cord-253295-82ydczid	161	25	distinguish	distinguish	VB
cord-253295-82ydczid	161	26	minimally	minimally	RB
cord-253295-82ydczid	161	27	modified	modify	VBN
cord-253295-82ydczid	161	28	variant	variant	NN
cord-253295-82ydczid	161	29	antigens	antigen	NNS
cord-253295-82ydczid	161	30	(	(	-LRB-
cord-253295-82ydczid	161	31	for	for	IN
cord-253295-82ydczid	161	32	instance	instance	NN
cord-253295-82ydczid	161	33	,	,	,
cord-253295-82ydczid	161	34	phosphorylated	phosphorylated	JJ
cord-253295-82ydczid	161	35	proteins	protein	NNS
cord-253295-82ydczid	161	36	or	or	CC
cord-253295-82ydczid	161	37	proteins	protein	NNS
cord-253295-82ydczid	161	38	with	with	IN
cord-253295-82ydczid	161	39	single	single	JJ
cord-253295-82ydczid	161	40	amino	amino	NN
cord-253295-82ydczid	161	41	acid	acid	NN
cord-253295-82ydczid	161	42	substitutions	substitution	NNS
cord-253295-82ydczid	161	43	)	)	-RRB-
cord-253295-82ydczid	161	44	.	.	.
cord-253295-82ydczid	162	1	Natural	natural	JJ
cord-253295-82ydczid	162	2	product	product	NN
cord-253295-82ydczid	162	3	chemistry	chemistry	NN
cord-253295-82ydczid	162	4	and	and	CC
cord-253295-82ydczid	162	5	the	the	DT
cord-253295-82ydczid	162	6	rise	rise	NN
cord-253295-82ydczid	162	7	of	of	IN
cord-253295-82ydczid	162	8	clinical	clinical	JJ
cord-253295-82ydczid	162	9	laboratories	laboratory	NNS
cord-253295-82ydczid	162	10	Diseases	disease	NNS
cord-253295-82ydczid	162	11	due	due	JJ
cord-253295-82ydczid	162	12	to	to	IN
cord-253295-82ydczid	162	13	dietary	dietary	JJ
cord-253295-82ydczid	162	14	deficiencies	deficiency	NNS
cord-253295-82ydczid	162	15	(	(	-LRB-
cord-253295-82ydczid	162	16	like	like	IN
cord-253295-82ydczid	162	17	scurvy	scurvy	NN
cord-253295-82ydczid	162	18	)	)	-RRB-
cord-253295-82ydczid	162	19	and	and	CC
cord-253295-82ydczid	162	20	hormonal	hormonal	JJ
cord-253295-82ydczid	162	21	imbalances	imbalance	NNS
cord-253295-82ydczid	162	22	(	(	-LRB-
cord-253295-82ydczid	162	23	like	like	IN
cord-253295-82ydczid	162	24	diabetes	diabetes	NN
cord-253295-82ydczid	162	25	mellitus	mellitus	NN
cord-253295-82ydczid	162	26	)	)	-RRB-
cord-253295-82ydczid	162	27	were	be	VBD
cord-253295-82ydczid	162	28	described	describe	VBN
cord-253295-82ydczid	162	29	clinically	clinically	RB
cord-253295-82ydczid	162	30	long	long	RB
cord-253295-82ydczid	162	31	before	before	IN
cord-253295-82ydczid	162	32	they	-PRON-	PRP
cord-253295-82ydczid	162	33	were	be	VBD
cord-253295-82ydczid	162	34	understood	understand	VBN
cord-253295-82ydczid	162	35	pathologically	pathologically	RB
cord-253295-82ydczid	162	36	.	.	.
cord-253295-82ydczid	163	1	Dietary	dietary	JJ
cord-253295-82ydczid	163	2	deficiency	deficiency	NN
cord-253295-82ydczid	163	3	diseases	disease	NNS
cord-253295-82ydczid	163	4	prompted	prompt	VBD
cord-253295-82ydczid	163	5	searches	search	NNS
cord-253295-82ydczid	163	6	for	for	IN
cord-253295-82ydczid	163	7	the	the	DT
cord-253295-82ydczid	163	8	critical	critical	JJ
cord-253295-82ydczid	163	9	metabolic	metabolic	JJ
cord-253295-82ydczid	163	10	cofactors	cofactor	NNS
cord-253295-82ydczid	163	11	,	,	,
cord-253295-82ydczid	163	12	so	so	RB
cord-253295-82ydczid	163	13	-	-	HYPH
cord-253295-82ydczid	163	14	called	call	VBN
cord-253295-82ydczid	163	15	'	'	``
cord-253295-82ydczid	163	16	vital	vital	JJ
cord-253295-82ydczid	163	17	amines	amine	NNS
cord-253295-82ydczid	163	18	'	'	''
cord-253295-82ydczid	163	19	(	(	-LRB-
cord-253295-82ydczid	163	20	vitamins	vitamin	NNS
cord-253295-82ydczid	163	21	)	)	-RRB-
cord-253295-82ydczid	163	22	.	.	.
cord-253295-82ydczid	164	1	Xerophthalmia	Xerophthalmia	NNP
cord-253295-82ydczid	164	2	was	be	VBD
cord-253295-82ydczid	164	3	linked	link	VBN
cord-253295-82ydczid	164	4	to	to	IN
cord-253295-82ydczid	164	5	retinol	retinol	NN
cord-253295-82ydczid	164	6	(	(	-LRB-
cord-253295-82ydczid	164	7	vitamin	vitamin	NN
cord-253295-82ydczid	164	8	A	a	NN
cord-253295-82ydczid	164	9	)	)	-RRB-
cord-253295-82ydczid	164	10	deficiency	deficiency	NN
cord-253295-82ydczid	164	11	in	in	IN
cord-253295-82ydczid	164	12	1917	1917	CD
cord-253295-82ydczid	164	13	(	(	-LRB-
cord-253295-82ydczid	164	14	McCollum	McCollum	NNP
cord-253295-82ydczid	164	15	)	)	-RRB-
cord-253295-82ydczid	164	16	.	.	.
cord-253295-82ydczid	165	1	Rickets	ricket	NNS
cord-253295-82ydczid	165	2	was	be	VBD
cord-253295-82ydczid	165	3	linked	link	VBN
cord-253295-82ydczid	165	4	to	to	IN
cord-253295-82ydczid	165	5	calcitriol	calcitriol	FW
cord-253295-82ydczid	165	6	(	(	-LRB-
cord-253295-82ydczid	165	7	vitamin	vitamin	NN
cord-253295-82ydczid	165	8	D	D	NNP
cord-253295-82ydczid	165	9	)	)	-RRB-
cord-253295-82ydczid	165	10	deficiency	deficiency	NN
cord-253295-82ydczid	165	11	in	in	IN
cord-253295-82ydczid	165	12	1926	1926	CD
cord-253295-82ydczid	165	13	.	.	.
cord-253295-82ydczid	166	1	Beri	Beri	NNP
cord-253295-82ydczid	166	2	-	-	HYPH
cord-253295-82ydczid	166	3	beri	beri	NNP
cord-253295-82ydczid	166	4	was	be	VBD
cord-253295-82ydczid	166	5	linked	link	VBN
cord-253295-82ydczid	166	6	to	to	IN
cord-253295-82ydczid	166	7	a	a	DT
cord-253295-82ydczid	166	8	deficiency	deficiency	NN
cord-253295-82ydczid	166	9	of	of	IN
cord-253295-82ydczid	166	10	thiamine	thiamine	NN
cord-253295-82ydczid	166	11	(	(	-LRB-
cord-253295-82ydczid	166	12	vitamin	vitamin	NN
cord-253295-82ydczid	166	13	B1	b1	NN
cord-253295-82ydczid	166	14	)	)	-RRB-
cord-253295-82ydczid	166	15	in	in	IN
cord-253295-82ydczid	166	16	1926	1926	CD
cord-253295-82ydczid	166	17	.	.	.
cord-253295-82ydczid	167	1	Scurvy	scurvy	NN
cord-253295-82ydczid	167	2	was	be	VBD
cord-253295-82ydczid	167	3	linked	link	VBN
cord-253295-82ydczid	167	4	to	to	IN
cord-253295-82ydczid	167	5	ascorbic	ascorbic	NN
cord-253295-82ydczid	167	6	acid	acid	NN
cord-253295-82ydczid	167	7	(	(	-LRB-
cord-253295-82ydczid	167	8	vitamin	vitamin	NN
cord-253295-82ydczid	167	9	C	c	NN
cord-253295-82ydczid	167	10	)	)	-RRB-
cord-253295-82ydczid	167	11	deficiency	deficiency	NN
cord-253295-82ydczid	167	12	in	in	IN
cord-253295-82ydczid	167	13	1927	1927	CD
cord-253295-82ydczid	167	14	.	.	.
cord-253295-82ydczid	168	1	Pellagra	Pellagra	NNP
cord-253295-82ydczid	168	2	in	in	IN
cord-253295-82ydczid	168	3	the	the	DT
cord-253295-82ydczid	168	4	United	United	NNP
cord-253295-82ydczid	168	5	States	States	NNP
cord-253295-82ydczid	168	6	was	be	VBD
cord-253295-82ydczid	168	7	linked	link	VBN
cord-253295-82ydczid	168	8	to	to	IN
cord-253295-82ydczid	168	9	niacin	niacin	JJ
cord-253295-82ydczid	168	10	deficiency	deficiency	NN
cord-253295-82ydczid	168	11	in	in	IN
cord-253295-82ydczid	168	12	1937	1937	CD
cord-253295-82ydczid	168	13	.	.	.
cord-253295-82ydczid	169	1	Pernicious	pernicious	JJ
cord-253295-82ydczid	169	2	anemia	anemia	NN
cord-253295-82ydczid	169	3	was	be	VBD
cord-253295-82ydczid	169	4	linked	link	VBN
cord-253295-82ydczid	169	5	to	to	IN
cord-253295-82ydczid	169	6	cobalamin	cobalamin	NN
cord-253295-82ydczid	169	7	(	(	-LRB-
cord-253295-82ydczid	169	8	vitamin	vitamin	NN
cord-253295-82ydczid	169	9	B12	b12	NN
cord-253295-82ydczid	169	10	)	)	-RRB-
cord-253295-82ydczid	169	11	deficiency	deficiency	NN
cord-253295-82ydczid	169	12	in	in	IN
cord-253295-82ydczid	169	13	1948	1948	CD
cord-253295-82ydczid	169	14	.	.	.
cord-253295-82ydczid	170	1	It	-PRON-	PRP
cord-253295-82ydczid	170	2	is	be	VBZ
cord-253295-82ydczid	170	3	currently	currently	RB
cord-253295-82ydczid	170	4	unusual	unusual	JJ
cord-253295-82ydczid	170	5	to	to	TO
cord-253295-82ydczid	170	6	see	see	VB
cord-253295-82ydczid	170	7	morphologic	morphologic	JJ
cord-253295-82ydczid	170	8	features	feature	NNS
cord-253295-82ydczid	170	9	of	of	IN
cord-253295-82ydczid	170	10	these	these	DT
cord-253295-82ydczid	170	11	diseases	disease	NNS
cord-253295-82ydczid	170	12	in	in	IN
cord-253295-82ydczid	170	13	this	this	DT
cord-253295-82ydczid	170	14	country	country	NN
cord-253295-82ydczid	170	15	.	.	.
cord-253295-82ydczid	171	1	Diseases	disease	NNS
cord-253295-82ydczid	171	2	due	due	JJ
cord-253295-82ydczid	171	3	to	to	IN
cord-253295-82ydczid	171	4	non	non	JJ
cord-253295-82ydczid	171	5	-	-	JJ
cord-253295-82ydczid	171	6	dietary	dietary	JJ
cord-253295-82ydczid	171	7	physiologic	physiologic	JJ
cord-253295-82ydczid	171	8	imbalances	imbalance	NNS
cord-253295-82ydczid	171	9	prompted	prompt	VBD
cord-253295-82ydczid	171	10	isolation	isolation	NN
cord-253295-82ydczid	171	11	of	of	IN
cord-253295-82ydczid	171	12	circulating	circulate	VBG
cord-253295-82ydczid	171	13	molecules	molecule	NNS
cord-253295-82ydczid	171	14	with	with	IN
cord-253295-82ydczid	171	15	systemic	systemic	JJ
cord-253295-82ydczid	171	16	effects	effect	NNS
cord-253295-82ydczid	171	17	,	,	,
cord-253295-82ydczid	171	18	i.e.	i.e.	FW
cord-253295-82ydczid	171	19	the	the	DT
cord-253295-82ydczid	171	20	hormones	hormone	NNS
cord-253295-82ydczid	171	21	.	.	.
cord-253295-82ydczid	172	1	Parathyroid	parathyroid	JJ
cord-253295-82ydczid	172	2	hormone	hormone	NN
cord-253295-82ydczid	172	3	was	be	VBD
cord-253295-82ydczid	172	4	isolated	isolate	VBN
cord-253295-82ydczid	172	5	(	(	-LRB-
cord-253295-82ydczid	172	6	Berman	Berman	NNP
cord-253295-82ydczid	172	7	,	,	,
cord-253295-82ydczid	172	8	Collip	Collip	NNP
cord-253295-82ydczid	172	9	)	)	-RRB-
cord-253295-82ydczid	172	10	in	in	IN
cord-253295-82ydczid	172	11	the	the	DT
cord-253295-82ydczid	172	12	1920s	1920s	CD
cord-253295-82ydczid	172	13	.	.	.
cord-253295-82ydczid	173	1	Thyroxine	Thyroxine	NNP
cord-253295-82ydczid	173	2	and	and	CC
cord-253295-82ydczid	173	3	cortisone	cortisone	NN
cord-253295-82ydczid	173	4	were	be	VBD
cord-253295-82ydczid	173	5	isolated	isolate	VBN
cord-253295-82ydczid	173	6	(	(	-LRB-
cord-253295-82ydczid	173	7	Kendall	Kendall	NNP
cord-253295-82ydczid	173	8	)	)	-RRB-
cord-253295-82ydczid	173	9	in	in	IN
cord-253295-82ydczid	173	10	1915	1915	CD
cord-253295-82ydczid	173	11	,	,	,
cord-253295-82ydczid	173	12	and	and	CC
cord-253295-82ydczid	173	13	table	table	NN
cord-253295-82ydczid	173	14	salt	salt	NN
cord-253295-82ydczid	173	15	was	be	VBD
cord-253295-82ydczid	173	16	iodized	iodize	VBN
cord-253295-82ydczid	173	17	starting	start	VBG
cord-253295-82ydczid	173	18	in	in	IN
cord-253295-82ydczid	173	19	1917	1917	CD
cord-253295-82ydczid	173	20	.	.	.
cord-253295-82ydczid	174	1	Insulin	insulin	NN
cord-253295-82ydczid	174	2	was	be	VBD
cord-253295-82ydczid	174	3	isolated	isolate	VBN
cord-253295-82ydczid	174	4	(	(	-LRB-
cord-253295-82ydczid	174	5	Banting	Banting	NNP
cord-253295-82ydczid	174	6	,	,	,
cord-253295-82ydczid	174	7	Best	good	JJS
cord-253295-82ydczid	174	8	)	)	-RRB-
cord-253295-82ydczid	174	9	in	in	IN
cord-253295-82ydczid	174	10	1921	1921	CD
cord-253295-82ydczid	174	11	,	,	,
cord-253295-82ydczid	174	12	non	non	JJ
cord-253295-82ydczid	174	13	-	-	JJ
cord-253295-82ydczid	174	14	human	human	JJ
cord-253295-82ydczid	174	15	insulin	insulin	NN
cord-253295-82ydczid	174	16	was	be	VBD
cord-253295-82ydczid	174	17	industrially	industrially	RB
cord-253295-82ydczid	174	18	purified	purify	VBN
cord-253295-82ydczid	174	19	and	and	CC
cord-253295-82ydczid	174	20	marketed	market	VBN
cord-253295-82ydczid	174	21	soon	soon	RB
cord-253295-82ydczid	174	22	thereafter	thereafter	RB
cord-253295-82ydczid	174	23	,	,	,
cord-253295-82ydczid	174	24	and	and	CC
cord-253295-82ydczid	174	25	recombinant	recombinant	JJ
cord-253295-82ydczid	174	26	human	human	JJ
cord-253295-82ydczid	174	27	insulin	insulin	NN
cord-253295-82ydczid	174	28	was	be	VBD
cord-253295-82ydczid	174	29	marketed	market	VBN
cord-253295-82ydczid	174	30	starting	start	VBG
cord-253295-82ydczid	174	31	in	in	IN
cord-253295-82ydczid	174	32	1982	1982	CD
cord-253295-82ydczid	174	33	.	.	.
cord-253295-82ydczid	175	1	These	these	DT
cord-253295-82ydczid	175	2	examples	example	NNS
cord-253295-82ydczid	175	3	highlight	highlight	VBP
cord-253295-82ydczid	175	4	the	the	DT
cord-253295-82ydczid	175	5	ability	ability	NN
cord-253295-82ydczid	175	6	of	of	IN
cord-253295-82ydczid	175	7	20th	20th	JJ
cord-253295-82ydczid	175	8	century	century	NN
cord-253295-82ydczid	175	9	chemists	chemist	NNS
cord-253295-82ydczid	175	10	to	to	TO
cord-253295-82ydczid	175	11	fractionate	fractionate	VB
cord-253295-82ydczid	175	12	,	,	,
cord-253295-82ydczid	175	13	purify	purify	VB
cord-253295-82ydczid	175	14	,	,	,
cord-253295-82ydczid	175	15	synthesize	synthesize	VB
cord-253295-82ydczid	175	16	,	,	,
cord-253295-82ydczid	175	17	measure	measure	VB
cord-253295-82ydczid	175	18	bioactivity	bioactivity	NN
cord-253295-82ydczid	175	19	,	,	,
cord-253295-82ydczid	175	20	and	and	CC
cord-253295-82ydczid	175	21	manufacture	manufacture	VB
cord-253295-82ydczid	175	22	these	these	DT
cord-253295-82ydczid	175	23	compounds	compound	NNS
cord-253295-82ydczid	175	24	for	for	IN
cord-253295-82ydczid	175	25	safe	safe	JJ
cord-253295-82ydczid	175	26	use	use	NN
cord-253295-82ydczid	175	27	by	by	IN
cord-253295-82ydczid	175	28	humans	human	NNS
cord-253295-82ydczid	175	29	.	.	.
cord-253295-82ydczid	176	1	Study	study	NN
cord-253295-82ydczid	176	2	of	of	IN
cord-253295-82ydczid	176	3	diseases	disease	NNS
cord-253295-82ydczid	176	4	due	due	JJ
cord-253295-82ydczid	176	5	to	to	IN
cord-253295-82ydczid	176	6	deficiencies	deficiency	NNS
cord-253295-82ydczid	176	7	and	and	CC
cord-253295-82ydczid	176	8	excesses	excess	NNS
cord-253295-82ydczid	176	9	of	of	IN
cord-253295-82ydczid	176	10	single	single	JJ
cord-253295-82ydczid	176	11	molecule	molecule	NN
cord-253295-82ydczid	176	12	function	function	NN
cord-253295-82ydczid	176	13	led	lead	VBD
cord-253295-82ydczid	176	14	to	to	IN
cord-253295-82ydczid	176	15	a	a	DT
cord-253295-82ydczid	176	16	mechanistic	mechanistic	JJ
cord-253295-82ydczid	176	17	understanding	understanding	NN
cord-253295-82ydczid	176	18	of	of	IN
cord-253295-82ydczid	176	19	biochemistry	biochemistry	NN
cord-253295-82ydczid	176	20	and	and	CC
cord-253295-82ydczid	176	21	physiology	physiology	NN
cord-253295-82ydczid	176	22	,	,	,
cord-253295-82ydczid	176	23	with	with	IN
cord-253295-82ydczid	176	24	resultant	resultant	JJ
cord-253295-82ydczid	176	25	interconnected	interconnect	VBN
cord-253295-82ydczid	176	26	reaction	reaction	NN
cord-253295-82ydczid	176	27	pathways	pathway	NNS
cord-253295-82ydczid	176	28	of	of	IN
cord-253295-82ydczid	176	29	byzantine	byzantine	JJ
cord-253295-82ydczid	176	30	complexity	complexity	NN
cord-253295-82ydczid	176	31	(	(	-LRB-
cord-253295-82ydczid	176	32	now	now	RB
cord-253295-82ydczid	176	33	referred	refer	VBN
cord-253295-82ydczid	176	34	to	to	IN
cord-253295-82ydczid	176	35	as	as	IN
cord-253295-82ydczid	176	36	systems	system	NNS
cord-253295-82ydczid	176	37	biology	biology	NN
cord-253295-82ydczid	176	38	)	)	-RRB-
cord-253295-82ydczid	176	39	.	.	.
cord-253295-82ydczid	177	1	Clinical	clinical	JJ
cord-253295-82ydczid	177	2	demand	demand	NN
cord-253295-82ydczid	177	3	for	for	IN
cord-253295-82ydczid	177	4	body	body	NN
cord-253295-82ydczid	177	5	fluid	fluid	NN
cord-253295-82ydczid	177	6	levels	level	NNS
cord-253295-82ydczid	177	7	of	of	IN
cord-253295-82ydczid	177	8	ions	ion	NNS
cord-253295-82ydczid	177	9	(	(	-LRB-
cord-253295-82ydczid	177	10	such	such	JJ
cord-253295-82ydczid	177	11	as	as	IN
cord-253295-82ydczid	177	12	sodium	sodium	NN
cord-253295-82ydczid	177	13	,	,	,
cord-253295-82ydczid	177	14	potassium	potassium	NN
cord-253295-82ydczid	177	15	chloride	chloride	NN
cord-253295-82ydczid	177	16	,	,	,
cord-253295-82ydczid	177	17	and	and	CC
cord-253295-82ydczid	177	18	bicarbonate	bicarbonate	NN
cord-253295-82ydczid	177	19	)	)	-RRB-
cord-253295-82ydczid	177	20	,	,	,
cord-253295-82ydczid	177	21	glucose	glucose	NN
cord-253295-82ydczid	177	22	,	,	,
cord-253295-82ydczid	177	23	creatinine	creatinine	NN
cord-253295-82ydczid	177	24	,	,	,
cord-253295-82ydczid	177	25	hormones	hormone	NNS
cord-253295-82ydczid	177	26	(	(	-LRB-
cord-253295-82ydczid	177	27	such	such	JJ
cord-253295-82ydczid	177	28	as	as	IN
cord-253295-82ydczid	177	29	thyroxine	thyroxine	JJ
cord-253295-82ydczid	177	30	and	and	CC
cord-253295-82ydczid	177	31	parathyroid	parathyroid	JJ
cord-253295-82ydczid	177	32	hormone	hormone	NN
cord-253295-82ydczid	177	33	)	)	-RRB-
cord-253295-82ydczid	177	34	,	,	,
cord-253295-82ydczid	177	35	albumin	albumin	NN
cord-253295-82ydczid	177	36	,	,	,
cord-253295-82ydczid	177	37	enzymes	enzyme	NNS
cord-253295-82ydczid	177	38	(	(	-LRB-
cord-253295-82ydczid	177	39	related	relate	VBN
cord-253295-82ydczid	177	40	to	to	IN
cord-253295-82ydczid	177	41	liver	liver	NN
cord-253295-82ydczid	177	42	and	and	CC
cord-253295-82ydczid	177	43	cardiac	cardiac	JJ
cord-253295-82ydczid	177	44	function	function	NN
cord-253295-82ydczid	177	45	)	)	-RRB-
cord-253295-82ydczid	177	46	,	,	,
cord-253295-82ydczid	177	47	and	and	CC
cord-253295-82ydczid	177	48	antibodies	antibody	NNS
cord-253295-82ydczid	177	49	(	(	-LRB-
cord-253295-82ydczid	177	50	reactive	reactive	JJ
cord-253295-82ydczid	177	51	to	to	IN
cord-253295-82ydczid	177	52	ASO	ASO	NNP
cord-253295-82ydczid	177	53	,	,	,
cord-253295-82ydczid	177	54	Rh	Rh	NNP
cord-253295-82ydczid	177	55	,	,	,
cord-253295-82ydczid	177	56	ABO	ABO	NNP
cord-253295-82ydczid	177	57	,	,	,
cord-253295-82ydczid	177	58	and	and	CC
cord-253295-82ydczid	177	59	HLA	HLA	NNP
cord-253295-82ydczid	177	60	antigens	antigen	NNS
cord-253295-82ydczid	177	61	)	)	-RRB-
cord-253295-82ydczid	177	62	led	lead	VBD
cord-253295-82ydczid	177	63	to	to	IN
cord-253295-82ydczid	177	64	the	the	DT
cord-253295-82ydczid	177	65	development	development	NN
cord-253295-82ydczid	177	66	of	of	IN
cord-253295-82ydczid	177	67	clinical	clinical	JJ
cord-253295-82ydczid	177	68	laboratories	laboratory	NNS
cord-253295-82ydczid	177	69	in	in	IN
cord-253295-82ydczid	177	70	chemistry	chemistry	NN
cord-253295-82ydczid	177	71	,	,	,
cord-253295-82ydczid	177	72	endocrinology	endocrinology	NN
cord-253295-82ydczid	177	73	,	,	,
cord-253295-82ydczid	177	74	immunopathology	immunopathology	NN
cord-253295-82ydczid	177	75	,	,	,
cord-253295-82ydczid	177	76	and	and	CC
cord-253295-82ydczid	177	77	blood	blood	NN
cord-253295-82ydczid	177	78	banking	banking	NN
cord-253295-82ydczid	177	79	.	.	.
cord-253295-82ydczid	178	1	Functional	functional	JJ
cord-253295-82ydczid	178	2	assays	assay	NNS
cord-253295-82ydczid	178	3	for	for	IN
cord-253295-82ydczid	178	4	coagulation	coagulation	NN
cord-253295-82ydczid	178	5	cascade	cascade	NN
cord-253295-82ydczid	178	6	status	status	NN
cord-253295-82ydczid	178	7	were	be	VBD
cord-253295-82ydczid	178	8	developed	develop	VBN
cord-253295-82ydczid	178	9	,	,	,
cord-253295-82ydczid	178	10	as	as	IN
cord-253295-82ydczid	178	11	were	be	VBD
cord-253295-82ydczid	178	12	methods	method	NNS
cord-253295-82ydczid	178	13	for	for	IN
cord-253295-82ydczid	178	14	estimating	estimate	VBG
cord-253295-82ydczid	178	15	blood	blood	NN
cord-253295-82ydczid	178	16	cell	cell	NN
cord-253295-82ydczid	178	17	concentration	concentration	NN
cord-253295-82ydczid	178	18	and	and	CC
cord-253295-82ydczid	178	19	differential	differential	NN
cord-253295-82ydczid	178	20	,	,	,
cord-253295-82ydczid	178	21	leading	lead	VBG
cord-253295-82ydczid	178	22	to	to	IN
cord-253295-82ydczid	178	23	coagulation	coagulation	NN
cord-253295-82ydczid	178	24	and	and	CC
cord-253295-82ydczid	178	25	hematology	hematology	NN
cord-253295-82ydczid	178	26	laboratories	laboratory	NNS
cord-253295-82ydczid	178	27	.	.	.
cord-253295-82ydczid	179	1	Serologic	Serologic	NNP
cord-253295-82ydczid	179	2	and	and	CC
cord-253295-82ydczid	179	3	cell	cell	NN
cord-253295-82ydczid	179	4	activation	activation	NN
cord-253295-82ydczid	179	5	assays	assay	NNS
cord-253295-82ydczid	179	6	to	to	TO
cord-253295-82ydczid	179	7	define	define	VB
cord-253295-82ydczid	179	8	HLA	HLA	NNP
cord-253295-82ydczid	179	9	haplotype	haplotype	NN
cord-253295-82ydczid	179	10	led	lead	VBD
cord-253295-82ydczid	179	11	to	to	IN
cord-253295-82ydczid	179	12	HLA	HLA	NNP
cord-253295-82ydczid	179	13	laboratories	laboratory	NNS
cord-253295-82ydczid	179	14	screening	screen	VBG
cord-253295-82ydczid	179	15	donors	donor	NNS
cord-253295-82ydczid	179	16	and	and	CC
cord-253295-82ydczid	179	17	recipients	recipient	NNS
cord-253295-82ydczid	179	18	in	in	IN
cord-253295-82ydczid	179	19	anticipation	anticipation	NN
cord-253295-82ydczid	179	20	of	of	IN
cord-253295-82ydczid	179	21	bone	bone	NN
cord-253295-82ydczid	179	22	marrow	marrow	NN
cord-253295-82ydczid	179	23	and	and	CC
cord-253295-82ydczid	179	24	solid	solid	JJ
cord-253295-82ydczid	179	25	organ	organ	NN
cord-253295-82ydczid	179	26	transplants	transplant	NNS
cord-253295-82ydczid	179	27	.	.	.
cord-253295-82ydczid	180	1	Culture	culture	NN
cord-253295-82ydczid	180	2	medium	medium	NN
cord-253295-82ydczid	180	3	-	-	HYPH
cord-253295-82ydczid	180	4	based	base	VBN
cord-253295-82ydczid	180	5	screening	screening	NN
cord-253295-82ydczid	180	6	for	for	IN
cord-253295-82ydczid	180	7	infectious	infectious	JJ
cord-253295-82ydczid	180	8	agents	agent	NNS
cord-253295-82ydczid	180	9	led	lead	VBD
cord-253295-82ydczid	180	10	to	to	IN
cord-253295-82ydczid	180	11	dedicated	dedicated	JJ
cord-253295-82ydczid	180	12	clinical	clinical	JJ
cord-253295-82ydczid	180	13	microbiology	microbiology	NN
cord-253295-82ydczid	180	14	laboratories	laboratory	NNS
cord-253295-82ydczid	180	15	,	,	,
cord-253295-82ydczid	180	16	which	which	WDT
cord-253295-82ydczid	180	17	are	be	VBP
cord-253295-82ydczid	180	18	beginning	begin	VBG
cord-253295-82ydczid	180	19	to	to	TO
cord-253295-82ydczid	180	20	incorporate	incorporate	VB
cord-253295-82ydczid	180	21	nucleic	nucleic	JJ
cord-253295-82ydczid	180	22	acid	acid	NN
cord-253295-82ydczid	180	23	screening	screening	NN
cord-253295-82ydczid	180	24	technologies	technology	NNS
cord-253295-82ydczid	180	25	for	for	IN
cord-253295-82ydczid	180	26	speciation	speciation	NN
cord-253295-82ydczid	180	27	and	and	CC
cord-253295-82ydczid	180	28	prediction	prediction	NN
cord-253295-82ydczid	180	29	of	of	IN
cord-253295-82ydczid	180	30	treatment	treatment	NN
cord-253295-82ydczid	180	31	response	response	NN
cord-253295-82ydczid	180	32	.	.	.
cord-253295-82ydczid	181	1	The	the	DT
cord-253295-82ydczid	181	2	clinical	clinical	JJ
cord-253295-82ydczid	181	3	laboratories	laboratory	NNS
cord-253295-82ydczid	181	4	now	now	RB
cord-253295-82ydczid	181	5	play	play	VBP
cord-253295-82ydczid	181	6	a	a	DT
cord-253295-82ydczid	181	7	critical	critical	JJ
cord-253295-82ydczid	181	8	,	,	,
cord-253295-82ydczid	181	9	specialized	specialized	JJ
cord-253295-82ydczid	181	10	role	role	NN
cord-253295-82ydczid	181	11	in	in	IN
cord-253295-82ydczid	181	12	inpatient	inpatient	JJ
cord-253295-82ydczid	181	13	and	and	CC
cord-253295-82ydczid	181	14	outpatient	outpatient	NN
cord-253295-82ydczid	181	15	management	management	NN
cord-253295-82ydczid	181	16	,	,	,
cord-253295-82ydczid	181	17	and	and	CC
cord-253295-82ydczid	181	18	their	-PRON-	PRP$
cord-253295-82ydczid	181	19	high	high	JJ
cord-253295-82ydczid	181	20	test	test	NN
cord-253295-82ydczid	181	21	volumes	volume	NNS
cord-253295-82ydczid	181	22	(	(	-LRB-
cord-253295-82ydczid	181	23	a	a	DT
cord-253295-82ydczid	181	24	700-bed	700-bed	CD
cord-253295-82ydczid	181	25	hospital	hospital	NN
cord-253295-82ydczid	181	26	may	may	MD
cord-253295-82ydczid	181	27	perform	perform	VB
cord-253295-82ydczid	181	28	5	5	CD
cord-253295-82ydczid	181	29	million	million	CD
cord-253295-82ydczid	181	30	tests	test	NNS
cord-253295-82ydczid	181	31	per	per	IN
cord-253295-82ydczid	181	32	year	year	NN
cord-253295-82ydczid	181	33	)	)	-RRB-
cord-253295-82ydczid	181	34	have	have	VBP
cord-253295-82ydczid	181	35	catalyzed	catalyze	VBN
cord-253295-82ydczid	181	36	computer	computer	NN
cord-253295-82ydczid	181	37	databases	database	NNS
cord-253295-82ydczid	181	38	for	for	IN
cord-253295-82ydczid	181	39	central	central	JJ
cord-253295-82ydczid	181	40	record	record	NN
cord-253295-82ydczid	181	41	-	-	HYPH
cord-253295-82ydczid	181	42	keeping	keeping	NN
cord-253295-82ydczid	181	43	of	of	IN
cord-253295-82ydczid	181	44	results	result	NNS
cord-253295-82ydczid	181	45	.	.	.
cord-253295-82ydczid	182	1	The	the	DT
cord-253295-82ydczid	182	2	previous	previous	JJ
cord-253295-82ydczid	182	3	vignettes	vignette	NNS
cord-253295-82ydczid	182	4	indicate	indicate	VBP
cord-253295-82ydczid	182	5	a	a	DT
cord-253295-82ydczid	182	6	scientific	scientific	JJ
cord-253295-82ydczid	182	7	approach	approach	NN
cord-253295-82ydczid	182	8	to	to	IN
cord-253295-82ydczid	182	9	natural	natural	JJ
cord-253295-82ydczid	182	10	products	product	NNS
cord-253295-82ydczid	182	11	of	of	IN
cord-253295-82ydczid	182	12	the	the	DT
cord-253295-82ydczid	182	13	steroid	steroid	NN
cord-253295-82ydczid	182	14	and	and	CC
cord-253295-82ydczid	182	15	protein	protein	NN
cord-253295-82ydczid	182	16	types	type	NNS
cord-253295-82ydczid	182	17	,	,	,
cord-253295-82ydczid	182	18	but	but	CC
cord-253295-82ydczid	182	19	do	do	VBP
cord-253295-82ydczid	182	20	not	not	RB
cord-253295-82ydczid	182	21	indicate	indicate	VB
cord-253295-82ydczid	182	22	how	how	WRB
cord-253295-82ydczid	182	23	proteins	protein	NNS
cord-253295-82ydczid	182	24	are	be	VBP
cord-253295-82ydczid	182	25	encoded	encode	VBN
cord-253295-82ydczid	182	26	,	,	,
cord-253295-82ydczid	182	27	what	what	WP
cord-253295-82ydczid	182	28	accounts	account	VBZ
cord-253295-82ydczid	182	29	for	for	IN
cord-253295-82ydczid	182	30	variation	variation	NN
cord-253295-82ydczid	182	31	in	in	IN
cord-253295-82ydczid	182	32	the	the	DT
cord-253295-82ydczid	182	33	same	same	JJ
cord-253295-82ydczid	182	34	protein	protein	NN
cord-253295-82ydczid	182	35	in	in	IN
cord-253295-82ydczid	182	36	the	the	DT
cord-253295-82ydczid	182	37	population	population	NN
cord-253295-82ydczid	182	38	,	,	,
cord-253295-82ydczid	182	39	or	or	CC
cord-253295-82ydczid	182	40	how	how	WRB
cord-253295-82ydczid	182	41	inherited	inherit	VBN
cord-253295-82ydczid	182	42	diseases	disease	NNS
cord-253295-82ydczid	182	43	are	be	VBP
cord-253295-82ydczid	182	44	inherited	inherit	VBN
cord-253295-82ydczid	182	45	.	.	.
cord-253295-82ydczid	183	1	It	-PRON-	PRP
cord-253295-82ydczid	183	2	turns	turn	VBZ
cord-253295-82ydczid	183	3	out	out	RP
cord-253295-82ydczid	183	4	that	that	IN
cord-253295-82ydczid	183	5	the	the	DT
cord-253295-82ydczid	183	6	instruction	instruction	NN
cord-253295-82ydczid	183	7	set	set	VBN
cord-253295-82ydczid	183	8	for	for	IN
cord-253295-82ydczid	183	9	protein	protein	NN
cord-253295-82ydczid	183	10	sequence	sequence	NN
cord-253295-82ydczid	183	11	is	be	VBZ
cord-253295-82ydczid	183	12	defined	define	VBN
cord-253295-82ydczid	183	13	by	by	IN
cord-253295-82ydczid	183	14	DNA	dna	NN
cord-253295-82ydczid	183	15	sequence	sequence	NN
cord-253295-82ydczid	183	16	.	.	.
cord-253295-82ydczid	184	1	The	the	DT
cord-253295-82ydczid	184	2	role	role	NN
cord-253295-82ydczid	184	3	of	of	IN
cord-253295-82ydczid	184	4	nucleoproteins	nucleoprotein	NNS
cord-253295-82ydczid	184	5	as	as	IN
cord-253295-82ydczid	184	6	a	a	DT
cord-253295-82ydczid	184	7	genetic	genetic	JJ
cord-253295-82ydczid	184	8	substance	substance	NN
cord-253295-82ydczid	184	9	was	be	VBD
cord-253295-82ydczid	184	10	alluded	allude	VBN
cord-253295-82ydczid	184	11	to	to	IN
cord-253295-82ydczid	184	12	by	by	IN
cord-253295-82ydczid	184	13	Miescher	Miescher	NNP
cord-253295-82ydczid	184	14	in	in	IN
cord-253295-82ydczid	184	15	1871	1871	CD
cord-253295-82ydczid	184	16	,	,	,
cord-253295-82ydczid	184	17	and	and	CC
cord-253295-82ydczid	184	18	was	be	VBD
cord-253295-82ydczid	184	19	shown	show	VBN
cord-253295-82ydczid	184	20	by	by	IN
cord-253295-82ydczid	184	21	Avery	Avery	NNP
cord-253295-82ydczid	184	22	to	to	TO
cord-253295-82ydczid	184	23	be	be	VB
cord-253295-82ydczid	184	24	the	the	DT
cord-253295-82ydczid	184	25	pneumococcal	pneumococcal	JJ
cord-253295-82ydczid	184	26	transforming	transform	VBG
cord-253295-82ydczid	184	27	principle	principle	NN
cord-253295-82ydczid	184	28	in	in	IN
cord-253295-82ydczid	184	29	1944	1944	CD
cord-253295-82ydczid	184	30	.	.	.
cord-253295-82ydczid	185	1	The	the	DT
cord-253295-82ydczid	185	2	discovery	discovery	NN
cord-253295-82ydczid	185	3	of	of	IN
cord-253295-82ydczid	185	4	X	x	NN
cord-253295-82ydczid	185	5	-	-	NN
cord-253295-82ydczid	185	6	ray	ray	JJ
cord-253295-82ydczid	185	7	crystallography	crystallography	NN
cord-253295-82ydczid	185	8	in	in	IN
cord-253295-82ydczid	185	9	1912	1912	CD
cord-253295-82ydczid	185	10	made	make	VBD
cord-253295-82ydczid	185	11	it	-PRON-	PRP
cord-253295-82ydczid	185	12	possible	possible	JJ
cord-253295-82ydczid	185	13	for	for	IN
cord-253295-82ydczid	185	14	Franklin	Franklin	NNP
cord-253295-82ydczid	185	15	,	,	,
cord-253295-82ydczid	185	16	Wilkins	Wilkins	NNP
cord-253295-82ydczid	185	17	,	,	,
cord-253295-82ydczid	185	18	and	and	CC
cord-253295-82ydczid	185	19	Gosling	Gosling	NNP
cord-253295-82ydczid	185	20	to	to	TO
cord-253295-82ydczid	185	21	study	study	VB
cord-253295-82ydczid	185	22	DNA	dna	NN
cord-253295-82ydczid	185	23	crystal	crystal	NN
cord-253295-82ydczid	185	24	structure	structure	NN
cord-253295-82ydczid	185	25	,	,	,
cord-253295-82ydczid	185	26	and	and	CC
cord-253295-82ydczid	185	27	led	lead	VBD
cord-253295-82ydczid	185	28	to	to	IN
cord-253295-82ydczid	185	29	the	the	DT
cord-253295-82ydczid	185	30	description	description	NN
cord-253295-82ydczid	185	31	of	of	IN
cord-253295-82ydczid	185	32	the	the	DT
cord-253295-82ydczid	185	33	antiparallel	antiparallel	NN
cord-253295-82ydczid	185	34	double	double	JJ
cord-253295-82ydczid	185	35	helix	helix	NN
cord-253295-82ydczid	185	36	of	of	IN
cord-253295-82ydczid	185	37	DNA	DNA	NNP
cord-253295-82ydczid	185	38	by	by	IN
cord-253295-82ydczid	185	39	Watson	Watson	NNP
cord-253295-82ydczid	185	40	and	and	CC
cord-253295-82ydczid	185	41	Crick	Crick	NNP
cord-253295-82ydczid	185	42	in	in	IN
cord-253295-82ydczid	185	43	1953	1953	CD
cord-253295-82ydczid	185	44	.	.	.
cord-253295-82ydczid	186	1	This	this	DT
cord-253295-82ydczid	186	2	seminal	seminal	JJ
cord-253295-82ydczid	186	3	event	event	NN
cord-253295-82ydczid	186	4	in	in	IN
cord-253295-82ydczid	186	5	history	history	NN
cord-253295-82ydczid	186	6	facilitated	facilitate	VBD
cord-253295-82ydczid	186	7	dissection	dissection	NN
cord-253295-82ydczid	186	8	of	of	IN
cord-253295-82ydczid	186	9	the	the	DT
cord-253295-82ydczid	186	10	instruction	instruction	NN
cord-253295-82ydczid	186	11	set	set	VBN
cord-253295-82ydczid	186	12	for	for	IN
cord-253295-82ydczid	186	13	an	an	DT
cord-253295-82ydczid	186	14	organism	organism	NN
cord-253295-82ydczid	186	15	,	,	,
cord-253295-82ydczid	186	16	with	with	IN
cord-253295-82ydczid	186	17	recognition	recognition	NN
cord-253295-82ydczid	186	18	that	that	IN
cord-253295-82ydczid	186	19	3-base	3-base	CD
cord-253295-82ydczid	186	20	codons	codon	NNS
cord-253295-82ydczid	186	21	specified	specify	VBN
cord-253295-82ydczid	186	22	amino	amino	NN
cord-253295-82ydczid	186	23	acids	acid	NNS
cord-253295-82ydczid	186	24	in	in	IN
cord-253295-82ydczid	186	25	1961	1961	CD
cord-253295-82ydczid	186	26	,	,	,
cord-253295-82ydczid	186	27	and	and	CC
cord-253295-82ydczid	186	28	description	description	NN
cord-253295-82ydczid	186	29	of	of	IN
cord-253295-82ydczid	186	30	the	the	DT
cord-253295-82ydczid	186	31	particular	particular	JJ
cord-253295-82ydczid	186	32	codons	codon	NNS
cord-253295-82ydczid	186	33	encoding	encode	VBG
cord-253295-82ydczid	186	34	each	each	DT
cord-253295-82ydczid	186	35	amino	amino	NN
cord-253295-82ydczid	186	36	acid	acid	NN
cord-253295-82ydczid	186	37	in	in	IN
cord-253295-82ydczid	186	38	1966	1966	CD
cord-253295-82ydczid	186	39	.	.	.
cord-253295-82ydczid	187	1	Demonstration	demonstration	NN
cord-253295-82ydczid	187	2	of	of	IN
cord-253295-82ydczid	187	3	in	in	IN
cord-253295-82ydczid	187	4	situ	situ	NN
cord-253295-82ydczid	187	5	hybridization	hybridization	NN
cord-253295-82ydczid	187	6	in	in	IN
cord-253295-82ydczid	187	7	1969	1969	CD
cord-253295-82ydczid	187	8	made	make	VBD
cord-253295-82ydczid	187	9	it	-PRON-	PRP
cord-253295-82ydczid	187	10	possible	possible	JJ
cord-253295-82ydczid	187	11	to	to	TO
cord-253295-82ydczid	187	12	localize	localize	VB
cord-253295-82ydczid	187	13	specific	specific	JJ
cord-253295-82ydczid	187	14	DNA	dna	NN
cord-253295-82ydczid	187	15	or	or	CC
cord-253295-82ydczid	187	16	RNA	RNA	NNP
cord-253295-82ydczid	187	17	sequences	sequence	NNS
cord-253295-82ydczid	187	18	within	within	IN
cord-253295-82ydczid	187	19	the	the	DT
cord-253295-82ydczid	187	20	cells	cell	NNS
cord-253295-82ydczid	187	21	of	of	IN
cord-253295-82ydczid	187	22	interest	interest	NN
cord-253295-82ydczid	187	23	.	.	.
cord-253295-82ydczid	188	1	Recognition	recognition	NN
cord-253295-82ydczid	188	2	and	and	CC
cord-253295-82ydczid	188	3	purification	purification	NN
cord-253295-82ydczid	188	4	of	of	IN
cord-253295-82ydczid	188	5	restriction	restriction	NN
cord-253295-82ydczid	188	6	endonucleases	endonuclease	NNS
cord-253295-82ydczid	188	7	and	and	CC
cord-253295-82ydczid	188	8	DNA	dna	NN
cord-253295-82ydczid	188	9	ligases	ligase	NNS
cord-253295-82ydczid	188	10	,	,	,
cord-253295-82ydczid	188	11	and	and	CC
cord-253295-82ydczid	188	12	the	the	DT
cord-253295-82ydczid	188	13	development	development	NN
cord-253295-82ydczid	188	14	of	of	IN
cord-253295-82ydczid	188	15	cloning	clone	VBG
cord-253295-82ydczid	188	16	vectors	vector	NNS
cord-253295-82ydczid	188	17	,	,	,
cord-253295-82ydczid	188	18	made	make	VBD
cord-253295-82ydczid	188	19	it	-PRON-	PRP
cord-253295-82ydczid	188	20	possible	possible	JJ
cord-253295-82ydczid	188	21	to	to	TO
cord-253295-82ydczid	188	22	clone	clone	VB
cord-253295-82ydczid	188	23	individual	individual	JJ
cord-253295-82ydczid	188	24	sequences	sequence	NNS
cord-253295-82ydczid	188	25	,	,	,
cord-253295-82ydczid	188	26	leading	lead	VBG
cord-253295-82ydczid	188	27	to	to	IN
cord-253295-82ydczid	188	28	methods	method	NNS
cord-253295-82ydczid	188	29	for	for	IN
cord-253295-82ydczid	188	30	synthesis	synthesis	NN
cord-253295-82ydczid	188	31	of	of	IN
cord-253295-82ydczid	188	32	natural	natural	JJ
cord-253295-82ydczid	188	33	products	product	NNS
cord-253295-82ydczid	188	34	(	(	-LRB-
cord-253295-82ydczid	188	35	such	such	JJ
cord-253295-82ydczid	188	36	as	as	IN
cord-253295-82ydczid	188	37	recombinant	recombinant	JJ
cord-253295-82ydczid	188	38	human	human	JJ
cord-253295-82ydczid	188	39	insulin	insulin	NN
cord-253295-82ydczid	188	40	in	in	IN
cord-253295-82ydczid	188	41	1978	1978	CD
cord-253295-82ydczid	188	42	)	)	-RRB-
cord-253295-82ydczid	188	43	.	.	.
cord-253295-82ydczid	189	1	Chemical	chemical	NN
cord-253295-82ydczid	189	2	methods	method	NNS
cord-253295-82ydczid	189	3	were	be	VBD
cord-253295-82ydczid	189	4	developed	develop	VBN
cord-253295-82ydczid	189	5	for	for	IN
cord-253295-82ydczid	189	6	sequencing	sequence	VBG
cord-253295-82ydczid	189	7	DNA	dna	NN
cord-253295-82ydczid	189	8	,	,	,
cord-253295-82ydczid	189	9	initially	initially	RB
cord-253295-82ydczid	189	10	with	with	IN
cord-253295-82ydczid	189	11	radioisotope	radioisotope	NN
cord-253295-82ydczid	189	12	-	-	HYPH
cord-253295-82ydczid	189	13	tagged	tag	VBN
cord-253295-82ydczid	189	14	nucleotide	nucleotide	JJ
cord-253295-82ydczid	189	15	detection	detection	NN
cord-253295-82ydczid	189	16	in	in	IN
cord-253295-82ydczid	189	17	plate	plate	NN
cord-253295-82ydczid	189	18	gels	gel	NNS
cord-253295-82ydczid	189	19	,	,	,
cord-253295-82ydczid	189	20	then	then	RB
cord-253295-82ydczid	189	21	with	with	IN
cord-253295-82ydczid	189	22	fluorescent	fluorescent	JJ
cord-253295-82ydczid	189	23	nucleotide	nucleotide	JJ
cord-253295-82ydczid	189	24	detection	detection	NN
cord-253295-82ydczid	189	25	in	in	IN
cord-253295-82ydczid	189	26	1986	1986	CD
cord-253295-82ydczid	189	27	.	.	.
cord-253295-82ydczid	190	1	Subsequent	subsequent	JJ
cord-253295-82ydczid	190	2	conversion	conversion	NN
cord-253295-82ydczid	190	3	to	to	IN
cord-253295-82ydczid	190	4	capillary	capillary	JJ
cord-253295-82ydczid	190	5	electrophoresis	electrophoresis	NN
cord-253295-82ydczid	190	6	and	and	CC
cord-253295-82ydczid	190	7	computer	computer	NN
cord-253295-82ydczid	190	8	scoring	scoring	NN
cord-253295-82ydczid	190	9	of	of	IN
cord-253295-82ydczid	190	10	sequence	sequence	NN
cord-253295-82ydczid	190	11	output	output	NN
cord-253295-82ydczid	190	12	allowed	allow	VBD
cord-253295-82ydczid	190	13	high	high	JJ
cord-253295-82ydczid	190	14	throughput	throughput	NN
cord-253295-82ydczid	190	15	protocols	protocol	NNS
cord-253295-82ydczid	190	16	which	which	WDT
cord-253295-82ydczid	190	17	generated	generate	VBD
cord-253295-82ydczid	190	18	the	the	DT
cord-253295-82ydczid	190	19	human	human	JJ
cord-253295-82ydczid	190	20	genome	genome	NN
cord-253295-82ydczid	190	21	sequence	sequence	NN
cord-253295-82ydczid	190	22	by	by	IN
cord-253295-82ydczid	190	23	2001	2001	CD
cord-253295-82ydczid	190	24	.	.	.
cord-253295-82ydczid	191	1	The	the	DT
cord-253295-82ydczid	191	2	development	development	NN
cord-253295-82ydczid	191	3	of	of	IN
cord-253295-82ydczid	191	4	polymerase	polymerase	NN
cord-253295-82ydczid	191	5	chain	chain	NN
cord-253295-82ydczid	191	6	reaction	reaction	NN
cord-253295-82ydczid	191	7	(	(	-LRB-
cord-253295-82ydczid	191	8	PCR	PCR	NNP
cord-253295-82ydczid	191	9	)	)	-RRB-
cord-253295-82ydczid	191	10	chemistry	chemistry	NN
cord-253295-82ydczid	191	11	in	in	IN
cord-253295-82ydczid	191	12	1986	1986	CD
cord-253295-82ydczid	191	13	has	have	VBZ
cord-253295-82ydczid	191	14	made	make	VBN
cord-253295-82ydczid	191	15	it	-PRON-	PRP
cord-253295-82ydczid	191	16	possible	possible	JJ
cord-253295-82ydczid	191	17	to	to	TO
cord-253295-82ydczid	191	18	quickly	quickly	RB
cord-253295-82ydczid	191	19	screen	screen	VB
cord-253295-82ydczid	191	20	for	for	IN
cord-253295-82ydczid	191	21	length	length	NN
cord-253295-82ydczid	191	22	polymorphisms	polymorphism	NNS
cord-253295-82ydczid	191	23	of	of	IN
cord-253295-82ydczid	191	24	microsatellite	microsatellite	JJ
cord-253295-82ydczid	191	25	(	(	-LRB-
cord-253295-82ydczid	191	26	identity	identity	NN
cord-253295-82ydczid	191	27	testing	testing	NN
cord-253295-82ydczid	191	28	,	,	,
cord-253295-82ydczid	191	29	donor	donor	NN
cord-253295-82ydczid	191	30	:	:	:
cord-253295-82ydczid	191	31	recipient	recipient	NN
cord-253295-82ydczid	191	32	ratio	ratio	NN
cord-253295-82ydczid	191	33	after	after	IN
cord-253295-82ydczid	191	34	bone	bone	NN
cord-253295-82ydczid	191	35	marrow	marrow	NN
cord-253295-82ydczid	191	36	transplant	transplant	NN
cord-253295-82ydczid	191	37	,	,	,
cord-253295-82ydczid	191	38	and	and	CC
cord-253295-82ydczid	191	39	microsatellite	microsatellite	JJ
cord-253295-82ydczid	191	40	instability	instability	NN
cord-253295-82ydczid	191	41	)	)	-RRB-
cord-253295-82ydczid	191	42	,	,	,
cord-253295-82ydczid	191	43	coding	code	VBG
cord-253295-82ydczid	191	44	sequence	sequence	NN
cord-253295-82ydczid	191	45	abnormalities	abnormality	NNS
cord-253295-82ydczid	191	46	in	in	IN
cord-253295-82ydczid	191	47	genes	gene	NNS
cord-253295-82ydczid	191	48	(	(	-LRB-
cord-253295-82ydczid	191	49	translocations	translocation	NNS
cord-253295-82ydczid	191	50	,	,	,
cord-253295-82ydczid	191	51	rearrangements	rearrangement	NNS
cord-253295-82ydczid	191	52	,	,	,
cord-253295-82ydczid	191	53	insertions	insertion	NNS
cord-253295-82ydczid	191	54	,	,	,
cord-253295-82ydczid	191	55	deletions	deletion	NNS
cord-253295-82ydczid	191	56	,	,	,
cord-253295-82ydczid	191	57	substitutions	substitution	NNS
cord-253295-82ydczid	191	58	)	)	-RRB-
cord-253295-82ydczid	191	59	,	,	,
cord-253295-82ydczid	191	60	and	and	CC
cord-253295-82ydczid	191	61	epigenetic	epigenetic	JJ
cord-253295-82ydczid	191	62	control	control	NN
cord-253295-82ydczid	191	63	of	of	IN
cord-253295-82ydczid	191	64	transcription	transcription	NN
cord-253295-82ydczid	191	65	(	(	-LRB-
cord-253295-82ydczid	191	66	promoter	promoter	NN
cord-253295-82ydczid	191	67	methylation	methylation	NN
cord-253295-82ydczid	191	68	)	)	-RRB-
cord-253295-82ydczid	191	69	in	in	IN
cord-253295-82ydczid	191	70	a	a	DT
cord-253295-82ydczid	191	71	targeted	target	VBN
cord-253295-82ydczid	191	72	fashion	fashion	NN
cord-253295-82ydczid	191	73	.	.	.
cord-253295-82ydczid	192	1	Quantitative	quantitative	JJ
cord-253295-82ydczid	192	2	PCR	PCR	NNP
cord-253295-82ydczid	192	3	methods	method	NNS
cord-253295-82ydczid	192	4	using	use	VBG
cord-253295-82ydczid	192	5	fluorescent	fluorescent	JJ
cord-253295-82ydczid	192	6	detection	detection	NN
cord-253295-82ydczid	192	7	of	of	IN
cord-253295-82ydczid	192	8	amplicons	amplicon	NNS
cord-253295-82ydczid	192	9	has	have	VBZ
cord-253295-82ydczid	192	10	made	make	VBN
cord-253295-82ydczid	192	11	it	-PRON-	PRP
cord-253295-82ydczid	192	12	possible	possible	JJ
cord-253295-82ydczid	192	13	to	to	TO
cord-253295-82ydczid	192	14	study	study	VB
cord-253295-82ydczid	192	15	DNA	DNA	NNP
cord-253295-82ydczid	192	16	and	and	CC
cord-253295-82ydczid	192	17	RNA	RNA	NNP
cord-253295-82ydczid	192	18	copy	copy	NN
cord-253295-82ydczid	192	19	number	number	NN
cord-253295-82ydczid	192	20	,	,	,
cord-253295-82ydczid	192	21	and	and	CC
cord-253295-82ydczid	192	22	to	to	TO
cord-253295-82ydczid	192	23	mimic	mimic	VB
cord-253295-82ydczid	192	24	Northern	northern	JJ
cord-253295-82ydczid	192	25	blots	blot	NNS
cord-253295-82ydczid	192	26	/	/	SYM
cord-253295-82ydczid	192	27	oligo	oligo	NN
cord-253295-82ydczid	192	28	microarrays	microarray	NNS
cord-253295-82ydczid	192	29	in	in	IN
cord-253295-82ydczid	192	30	estimating	estimate	VBG
cord-253295-82ydczid	192	31	RNA	RNA	NNP
cord-253295-82ydczid	192	32	transcript	transcript	NN
cord-253295-82ydczid	192	33	abundance	abundance	NN
cord-253295-82ydczid	192	34	for	for	IN
cord-253295-82ydczid	192	35	cluster	cluster	NN
cord-253295-82ydczid	192	36	analysis	analysis	NN
cord-253295-82ydczid	192	37	.	.	.
cord-253295-82ydczid	193	1	Massively	massively	RB
cord-253295-82ydczid	193	2	parallel	parallel	JJ
cord-253295-82ydczid	193	3	solid	solid	JJ
cord-253295-82ydczid	193	4	-	-	HYPH
cord-253295-82ydczid	193	5	state	state	NN
cord-253295-82ydczid	193	6	(	(	-LRB-
cord-253295-82ydczid	193	7	"	"	``
cord-253295-82ydczid	193	8	next	next	JJ
cord-253295-82ydczid	193	9	-	-	HYPH
cord-253295-82ydczid	193	10	generation	generation	NN
cord-253295-82ydczid	193	11	"	"	''
cord-253295-82ydczid	193	12	)	)	-RRB-
cord-253295-82ydczid	194	1	sequencing	sequencing	NN
cord-253295-82ydczid	194	2	chemistries	chemistry	NNS
cord-253295-82ydczid	194	3	now	now	RB
cord-253295-82ydczid	194	4	allow	allow	VBP
cord-253295-82ydczid	194	5	rapid	rapid	JJ
cord-253295-82ydczid	194	6	alignment	alignment	NN
cord-253295-82ydczid	194	7	of	of	IN
cord-253295-82ydczid	194	8	hundreds	hundred	NNS
cord-253295-82ydczid	194	9	of	of	IN
cord-253295-82ydczid	194	10	independent	independent	JJ
cord-253295-82ydczid	194	11	sequencing	sequencing	NN
cord-253295-82ydczid	194	12	reactions	reaction	NNS
cord-253295-82ydczid	194	13	,	,	,
cord-253295-82ydczid	194	14	facilitating	facilitate	VBG
cord-253295-82ydczid	194	15	rapid	rapid	JJ
cord-253295-82ydczid	194	16	comparison	comparison	NN
cord-253295-82ydczid	194	17	of	of	IN
cord-253295-82ydczid	194	18	germline	germline	JJ
cord-253295-82ydczid	194	19	and	and	CC
cord-253295-82ydczid	194	20	somatic	somatic	JJ
cord-253295-82ydczid	194	21	sequence	sequence	NN
cord-253295-82ydczid	194	22	,	,	,
cord-253295-82ydczid	194	23	as	as	RB
cord-253295-82ydczid	194	24	well	well	RB
cord-253295-82ydczid	194	25	as	as	IN
cord-253295-82ydczid	194	26	identification	identification	NN
cord-253295-82ydczid	194	27	of	of	IN
cord-253295-82ydczid	194	28	low	low	JJ
cord-253295-82ydczid	194	29	-	-	HYPH
cord-253295-82ydczid	194	30	abundance	abundance	NN
cord-253295-82ydczid	194	31	mutations	mutation	NNS
cord-253295-82ydczid	194	32	.	.	.
cord-253295-82ydczid	195	1	Diseases	disease	NNS
cord-253295-82ydczid	195	2	can	can	MD
cord-253295-82ydczid	195	3	be	be	VB
cord-253295-82ydczid	195	4	distinguished	distinguish	VBN
cord-253295-82ydczid	195	5	from	from	IN
cord-253295-82ydczid	195	6	each	each	DT
cord-253295-82ydczid	195	7	other	other	JJ
cord-253295-82ydczid	195	8	based	base	VBN
cord-253295-82ydczid	195	9	on	on	IN
cord-253295-82ydczid	195	10	differences	difference	NNS
cord-253295-82ydczid	195	11	at	at	IN
cord-253295-82ydczid	195	12	the	the	DT
cord-253295-82ydczid	195	13	molecular	molecular	JJ
cord-253295-82ydczid	195	14	,	,	,
cord-253295-82ydczid	195	15	cellular	cellular	JJ
cord-253295-82ydczid	195	16	,	,	,
cord-253295-82ydczid	195	17	tissue	tissue	NN
cord-253295-82ydczid	195	18	,	,	,
cord-253295-82ydczid	195	19	fluid	fluid	JJ
cord-253295-82ydczid	195	20	chemistry	chemistry	NN
cord-253295-82ydczid	195	21	,	,	,
cord-253295-82ydczid	195	22	and/or	and/or	CC
cord-253295-82ydczid	195	23	individual	individual	JJ
cord-253295-82ydczid	195	24	organism	organism	NN
cord-253295-82ydczid	195	25	level	level	NN
cord-253295-82ydczid	195	26	.	.	.
cord-253295-82ydczid	196	1	One	one	CD
cord-253295-82ydczid	196	2	hundred	hundred	CD
cord-253295-82ydczid	196	3	and	and	CC
cord-253295-82ydczid	196	4	sixty	sixty	CD
cord-253295-82ydczid	196	5	years	year	NNS
cord-253295-82ydczid	196	6	of	of	IN
cord-253295-82ydczid	196	7	attention	attention	NN
cord-253295-82ydczid	196	8	to	to	IN
cord-253295-82ydczid	196	9	the	the	DT
cord-253295-82ydczid	196	10	morphologic	morphologic	JJ
cord-253295-82ydczid	196	11	and	and	CC
cord-253295-82ydczid	196	12	clinical	clinical	JJ
cord-253295-82ydczid	196	13	correlates	correlate	NNS
cord-253295-82ydczid	196	14	of	of	IN
cord-253295-82ydczid	196	15	diseases	disease	NNS
cord-253295-82ydczid	196	16	has	have	VBZ
cord-253295-82ydczid	196	17	led	lead	VBN
cord-253295-82ydczid	196	18	to	to	IN
cord-253295-82ydczid	196	19	sets	set	NNS
cord-253295-82ydczid	196	20	of	of	IN
cord-253295-82ydczid	196	21	diagnostic	diagnostic	JJ
cord-253295-82ydczid	196	22	criteria	criterion	NNS
cord-253295-82ydczid	196	23	for	for	IN
cord-253295-82ydczid	196	24	the	the	DT
cord-253295-82ydczid	196	25	recognized	recognize	VBN
cord-253295-82ydczid	196	26	diseases	disease	NNS
cord-253295-82ydczid	196	27	,	,	,
cord-253295-82ydczid	196	28	as	as	RB
cord-253295-82ydczid	196	29	well	well	RB
cord-253295-82ydczid	196	30	as	as	IN
cord-253295-82ydczid	196	31	a	a	DT
cord-253295-82ydczid	196	32	reproducible	reproducible	JJ
cord-253295-82ydczid	196	33	nomenclature	nomenclature	NN
cord-253295-82ydczid	196	34	for	for	IN
cord-253295-82ydczid	196	35	rapid	rapid	JJ
cord-253295-82ydczid	196	36	description	description	NN
cord-253295-82ydczid	196	37	of	of	IN
cord-253295-82ydczid	196	38	the	the	DT
cord-253295-82ydczid	196	39	changes	change	NNS
cord-253295-82ydczid	196	40	associated	associate	VBN
cord-253295-82ydczid	196	41	with	with	IN
cord-253295-82ydczid	196	42	newly	newly	RB
cord-253295-82ydczid	196	43	discovered	discover	VBN
cord-253295-82ydczid	196	44	diseases	disease	NNS
cord-253295-82ydczid	196	45	.	.	.
cord-253295-82ydczid	197	1	Sets	set	NNS
cord-253295-82ydczid	197	2	of	of	IN
cord-253295-82ydczid	197	3	genotypic	genotypic	JJ
cord-253295-82ydczid	197	4	and	and	CC
cord-253295-82ydczid	197	5	phenotypic	phenotypic	JJ
cord-253295-82ydczid	197	6	abnormalities	abnormality	NNS
cord-253295-82ydczid	197	7	in	in	IN
cord-253295-82ydczid	197	8	the	the	DT
cord-253295-82ydczid	197	9	patient	patient	NN
cord-253295-82ydczid	197	10	are	be	VBP
cord-253295-82ydczid	197	11	used	use	VBN
cord-253295-82ydczid	197	12	to	to	TO
cord-253295-82ydczid	197	13	determine	determine	VB
cord-253295-82ydczid	197	14	a	a	DT
cord-253295-82ydczid	197	15	diagnosis	diagnosis	NN
cord-253295-82ydczid	197	16	,	,	,
cord-253295-82ydczid	197	17	which	which	WDT
cord-253295-82ydczid	197	18	then	then	RB
cord-253295-82ydczid	197	19	implies	imply	VBZ
cord-253295-82ydczid	197	20	a	a	DT
cord-253295-82ydczid	197	21	predictable	predictable	JJ
cord-253295-82ydczid	197	22	natural	natural	JJ
cord-253295-82ydczid	197	23	history	history	NN
cord-253295-82ydczid	197	24	and	and	CC
cord-253295-82ydczid	197	25	can	can	MD
cord-253295-82ydczid	197	26	be	be	VB
cord-253295-82ydczid	197	27	used	use	VBN
cord-253295-82ydczid	197	28	to	to	TO
cord-253295-82ydczid	197	29	optimize	optimize	VB
cord-253295-82ydczid	197	30	therapy	therapy	NN
cord-253295-82ydczid	197	31	by	by	IN
cord-253295-82ydczid	197	32	comparison	comparison	NN
cord-253295-82ydczid	197	33	of	of	IN
cord-253295-82ydczid	197	34	outcomes	outcome	NNS
cord-253295-82ydczid	197	35	among	among	IN
cord-253295-82ydczid	197	36	similarly	similarly	RB
cord-253295-82ydczid	197	37	afflicted	afflict	VBN
cord-253295-82ydczid	197	38	individuals	individual	NNS
cord-253295-82ydczid	197	39	.	.	.
cord-253295-82ydczid	198	1	The	the	DT
cord-253295-82ydczid	198	2	disease	disease	NN
cord-253295-82ydczid	198	3	diagnosis	diagnosis	NN
cord-253295-82ydczid	198	4	becomes	become	VBZ
cord-253295-82ydczid	198	5	the	the	DT
cord-253295-82ydczid	198	6	management	management	NN
cord-253295-82ydczid	198	7	variable	variable	NN
cord-253295-82ydczid	198	8	in	in	IN
cord-253295-82ydczid	198	9	clinical	clinical	JJ
cord-253295-82ydczid	198	10	medicine	medicine	NN
cord-253295-82ydczid	198	11	,	,	,
cord-253295-82ydczid	198	12	and	and	CC
cord-253295-82ydczid	198	13	management	management	NN
cord-253295-82ydczid	198	14	of	of	IN
cord-253295-82ydczid	198	15	the	the	DT
cord-253295-82ydczid	198	16	clinical	clinical	JJ
cord-253295-82ydczid	198	17	manifestations	manifestation	NNS
cord-253295-82ydczid	198	18	of	of	IN
cord-253295-82ydczid	198	19	diseases	disease	NNS
cord-253295-82ydczid	198	20	is	be	VBZ
cord-253295-82ydczid	198	21	the	the	DT
cord-253295-82ydczid	198	22	basis	basis	NN
cord-253295-82ydczid	198	23	for	for	IN
cord-253295-82ydczid	198	24	day	day	NN
cord-253295-82ydczid	198	25	-	-	HYPH
cord-253295-82ydczid	198	26	to	to	IN
cord-253295-82ydczid	198	27	-	-	HYPH
cord-253295-82ydczid	198	28	day	day	NN
cord-253295-82ydczid	198	29	activities	activity	NNS
cord-253295-82ydczid	198	30	in	in	IN
cord-253295-82ydczid	198	31	clinics	clinic	NNS
cord-253295-82ydczid	198	32	and	and	CC
cord-253295-82ydczid	198	33	hospitals	hospital	NNS
cord-253295-82ydczid	198	34	nationwide	nationwide	RB
cord-253295-82ydczid	198	35	.	.	.
cord-253295-82ydczid	199	1	The	the	DT
cord-253295-82ydczid	199	2	pathologist	pathologist	NN
cord-253295-82ydczid	199	3	is	be	VBZ
cord-253295-82ydczid	199	4	responsible	responsible	JJ
cord-253295-82ydczid	199	5	for	for	IN
cord-253295-82ydczid	199	6	integration	integration	NN
cord-253295-82ydczid	199	7	of	of	IN
cord-253295-82ydczid	199	8	the	the	DT
cord-253295-82ydczid	199	9	data	datum	NNS
cord-253295-82ydczid	199	10	obtained	obtain	VBN
cord-253295-82ydczid	199	11	at	at	IN
cord-253295-82ydczid	199	12	the	the	DT
cord-253295-82ydczid	199	13	clinical	clinical	JJ
cord-253295-82ydczid	199	14	,	,	,
cord-253295-82ydczid	199	15	gross	gross	JJ
cord-253295-82ydczid	199	16	,	,	,
cord-253295-82ydczid	199	17	morphologic	morphologic	JJ
cord-253295-82ydczid	199	18	,	,	,
cord-253295-82ydczid	199	19	and	and	CC
cord-253295-82ydczid	199	20	molecular	molecular	JJ
cord-253295-82ydczid	199	21	levels	level	NNS
cord-253295-82ydczid	199	22	,	,	,
cord-253295-82ydczid	199	23	and	and	CC
cord-253295-82ydczid	199	24	for	for	IN
cord-253295-82ydczid	199	25	issuing	issue	VBG
cord-253295-82ydczid	199	26	a	a	DT
cord-253295-82ydczid	199	27	clear	clear	JJ
cord-253295-82ydczid	199	28	and	and	CC
cord-253295-82ydczid	199	29	logical	logical	JJ
cord-253295-82ydczid	199	30	statement	statement	NN
cord-253295-82ydczid	199	31	of	of	IN
cord-253295-82ydczid	199	32	diagnosis	diagnosis	NN
cord-253295-82ydczid	199	33	.	.	.
cord-253295-82ydczid	200	1	Clinically	clinically	RB
cord-253295-82ydczid	200	2	,	,	,
cord-253295-82ydczid	200	3	diseases	disease	NNS
cord-253295-82ydczid	200	4	present	present	JJ
cord-253295-82ydczid	200	5	to	to	IN
cord-253295-82ydczid	200	6	front	front	JJ
cord-253295-82ydczid	200	7	-	-	HYPH
cord-253295-82ydczid	200	8	line	line	NN
cord-253295-82ydczid	200	9	physicians	physician	NNS
cord-253295-82ydczid	200	10	as	as	IN
cord-253295-82ydczid	200	11	patients	patient	NNS
cord-253295-82ydczid	200	12	with	with	IN
cord-253295-82ydczid	200	13	sets	set	NNS
cord-253295-82ydczid	200	14	of	of	IN
cord-253295-82ydczid	200	15	signs	sign	NNS
cord-253295-82ydczid	200	16	and	and	CC
cord-253295-82ydczid	200	17	symptoms	symptom	NNS
cord-253295-82ydczid	200	18	.	.	.
cord-253295-82ydczid	201	1	Symptoms	symptom	NNS
cord-253295-82ydczid	201	2	are	be	VBP
cord-253295-82ydczid	201	3	the	the	DT
cord-253295-82ydczid	201	4	patient	patient	NN
cord-253295-82ydczid	201	5	's	's	POS
cord-253295-82ydczid	201	6	complaints	complaint	NNS
cord-253295-82ydczid	201	7	of	of	IN
cord-253295-82ydczid	201	8	perceived	perceive	VBN
cord-253295-82ydczid	201	9	abnormalities	abnormality	NNS
cord-253295-82ydczid	201	10	.	.	.
cord-253295-82ydczid	202	1	Signs	sign	NNS
cord-253295-82ydczid	202	2	are	be	VBP
cord-253295-82ydczid	202	3	detected	detect	VBN
cord-253295-82ydczid	202	4	by	by	IN
cord-253295-82ydczid	202	5	examination	examination	NN
cord-253295-82ydczid	202	6	of	of	IN
cord-253295-82ydczid	202	7	the	the	DT
cord-253295-82ydczid	202	8	patient	patient	NN
cord-253295-82ydczid	202	9	.	.	.
cord-253295-82ydczid	203	1	The	the	DT
cord-253295-82ydczid	203	2	clinical	clinical	JJ
cord-253295-82ydczid	203	3	team	team	NN
cord-253295-82ydczid	203	4	,	,	,
cord-253295-82ydczid	203	5	including	include	VBG
cord-253295-82ydczid	203	6	the	the	DT
cord-253295-82ydczid	203	7	pathologist	pathologist	NN
cord-253295-82ydczid	203	8	,	,	,
cord-253295-82ydczid	203	9	will	will	MD
cord-253295-82ydczid	203	10	work	work	VB
cord-253295-82ydczid	203	11	up	up	RP
cord-253295-82ydczid	203	12	the	the	DT
cord-253295-82ydczid	203	13	patient	patient	NN
cord-253295-82ydczid	203	14	based	base	VBN
cord-253295-82ydczid	203	15	on	on	IN
cord-253295-82ydczid	203	16	the	the	DT
cord-253295-82ydczid	203	17	possible	possible	JJ
cord-253295-82ydczid	203	18	causes	cause	NNS
cord-253295-82ydczid	203	19	of	of	IN
cord-253295-82ydczid	203	20	the	the	DT
cord-253295-82ydczid	203	21	signs	sign	NNS
cord-253295-82ydczid	203	22	and	and	CC
cord-253295-82ydczid	203	23	symptoms	symptom	NNS
cord-253295-82ydczid	203	24	(	(	-LRB-
cord-253295-82ydczid	203	25	the	the	DT
cord-253295-82ydczid	203	26	differential	differential	JJ
cord-253295-82ydczid	203	27	diagnosis	diagnosis	NN
cord-253295-82ydczid	203	28	)	)	-RRB-
cord-253295-82ydczid	203	29	.	.	.
cord-253295-82ydczid	204	1	Depending	depend	VBG
cord-253295-82ydczid	204	2	on	on	IN
cord-253295-82ydczid	204	3	the	the	DT
cord-253295-82ydczid	204	4	differential	differential	JJ
cord-253295-82ydczid	204	5	diagnosis	diagnosis	NN
cord-253295-82ydczid	204	6	,	,	,
cord-253295-82ydczid	204	7	the	the	DT
cord-253295-82ydczid	204	8	workup	workup	NN
cord-253295-82ydczid	204	9	typically	typically	RB
cord-253295-82ydczid	204	10	involves	involve	VBZ
cord-253295-82ydczid	204	11	history	history	NN
cord-253295-82ydczid	204	12	-	-	HYPH
cord-253295-82ydczid	204	13	taking	take	VBG
cord-253295-82ydczid	204	14	,	,	,
cord-253295-82ydczid	204	15	physical	physical	JJ
cord-253295-82ydczid	204	16	examination	examination	NN
cord-253295-82ydczid	204	17	,	,	,
cord-253295-82ydczid	204	18	radiographic	radiographic	JJ
cord-253295-82ydczid	204	19	examination	examination	NN
cord-253295-82ydczid	204	20	,	,	,
cord-253295-82ydczid	204	21	fluid	fluid	JJ
cord-253295-82ydczid	204	22	tests	test	NNS
cord-253295-82ydczid	204	23	(	(	-LRB-
cord-253295-82ydczid	204	24	blood	blood	NN
cord-253295-82ydczid	204	25	,	,	,
cord-253295-82ydczid	204	26	urine	urine	NN
cord-253295-82ydczid	204	27	,	,	,
cord-253295-82ydczid	204	28	sputum	sputum	NN
cord-253295-82ydczid	204	29	,	,	,
cord-253295-82ydczid	204	30	stool	stool	NN
cord-253295-82ydczid	204	31	)	)	-RRB-
cord-253295-82ydczid	204	32	,	,	,
cord-253295-82ydczid	204	33	and	and	CC
cord-253295-82ydczid	204	34	possibly	possibly	RB
cord-253295-82ydczid	204	35	tissue	tissue	VB
cord-253295-82ydczid	204	36	biopsy	biopsy	NN
cord-253295-82ydczid	204	37	.	.	.
cord-253295-82ydczid	205	1	Radiographically	radiographically	RB
cord-253295-82ydczid	205	2	,	,	,
cord-253295-82ydczid	205	3	abnormalities	abnormality	NNS
cord-253295-82ydczid	205	4	in	in	IN
cord-253295-82ydczid	205	5	abundance	abundance	NN
cord-253295-82ydczid	205	6	,	,	,
cord-253295-82ydczid	205	7	density	density	NN
cord-253295-82ydczid	205	8	or	or	CC
cord-253295-82ydczid	205	9	chemical	chemical	JJ
cord-253295-82ydczid	205	10	microenvironment	microenvironment	NN
cord-253295-82ydczid	205	11	of	of	IN
cord-253295-82ydczid	205	12	tissues	tissue	NNS
cord-253295-82ydczid	205	13	allow	allow	VB
cord-253295-82ydczid	205	14	distinction	distinction	NN
cord-253295-82ydczid	205	15	from	from	IN
cord-253295-82ydczid	205	16	surrounding	surround	VBG
cord-253295-82ydczid	205	17	normal	normal	JJ
cord-253295-82ydczid	205	18	tissues	tissue	NNS
cord-253295-82ydczid	205	19	.	.	.
cord-253295-82ydczid	206	1	Traditionally	traditionally	RB
cord-253295-82ydczid	206	2	,	,	,
cord-253295-82ydczid	206	3	the	the	DT
cord-253295-82ydczid	206	4	absorption	absorption	NN
cord-253295-82ydczid	206	5	of	of	IN
cord-253295-82ydczid	206	6	electromagnetic	electromagnetic	JJ
cord-253295-82ydczid	206	7	waves	wave	NNS
cord-253295-82ydczid	206	8	by	by	IN
cord-253295-82ydczid	206	9	tissues	tissue	NNS
cord-253295-82ydczid	206	10	led	lead	VBD
cord-253295-82ydczid	206	11	to	to	IN
cord-253295-82ydczid	206	12	summation	summation	JJ
cord-253295-82ydczid	206	13	differences	difference	NNS
cord-253295-82ydczid	206	14	in	in	IN
cord-253295-82ydczid	206	15	exposure	exposure	NN
cord-253295-82ydczid	206	16	of	of	IN
cord-253295-82ydczid	206	17	silver	silver	NN
cord-253295-82ydczid	206	18	salt	salt	NN
cord-253295-82ydczid	206	19	photographic	photographic	JJ
cord-253295-82ydczid	206	20	film	film	NN
cord-253295-82ydczid	206	21	.	.	.
cord-253295-82ydczid	207	1	Tomographic	tomographic	JJ
cord-253295-82ydczid	207	2	approaches	approach	NNS
cord-253295-82ydczid	207	3	such	such	JJ
cord-253295-82ydczid	207	4	as	as	IN
cord-253295-82ydczid	207	5	computerized	computerized	JJ
cord-253295-82ydczid	207	6	tomography	tomography	NN
cord-253295-82ydczid	207	7	(	(	-LRB-
cord-253295-82ydczid	207	8	CT	CT	NNP
cord-253295-82ydczid	207	9	,	,	,
cord-253295-82ydczid	207	10	1972	1972	CD
cord-253295-82ydczid	207	11	)	)	-RRB-
cord-253295-82ydczid	207	12	and	and	CC
cord-253295-82ydczid	207	13	nuclear	nuclear	JJ
cord-253295-82ydczid	207	14	magnetic	magnetic	JJ
cord-253295-82ydczid	207	15	resonance	resonance	NN
cord-253295-82ydczid	207	16	(	(	-LRB-
cord-253295-82ydczid	207	17	NMR	NMR	NNP
cord-253295-82ydczid	207	18	,	,	,
cord-253295-82ydczid	207	19	MRI	MRI	NNP
cord-253295-82ydczid	207	20	,	,	,
cord-253295-82ydczid	207	21	1973	1973	CD
cord-253295-82ydczid	207	22	)	)	-RRB-
cord-253295-82ydczid	207	23	complemented	complement	VBD
cord-253295-82ydczid	207	24	summation	summation	JJ
cord-253295-82ydczid	207	25	radiology	radiology	NN
cord-253295-82ydczid	207	26	,	,	,
cord-253295-82ydczid	207	27	allowing	allow	VBG
cord-253295-82ydczid	207	28	finely	finely	RB
cord-253295-82ydczid	207	29	detailed	detailed	JJ
cord-253295-82ydczid	207	30	visualization	visualization	NN
cord-253295-82ydczid	207	31	of	of	IN
cord-253295-82ydczid	207	32	internal	internal	JJ
cord-253295-82ydczid	207	33	anatomy	anatomy	NN
cord-253295-82ydczid	207	34	in	in	IN
cord-253295-82ydczid	207	35	any	any	DT
cord-253295-82ydczid	207	36	plane	plane	NN
cord-253295-82ydczid	207	37	of	of	IN
cord-253295-82ydczid	207	38	section	section	NN
cord-253295-82ydczid	207	39	.	.	.
cord-253295-82ydczid	208	1	In	in	IN
cord-253295-82ydczid	208	2	the	the	DT
cord-253295-82ydczid	208	3	same	same	JJ
cord-253295-82ydczid	208	4	era	era	NN
cord-253295-82ydczid	208	5	,	,	,
cord-253295-82ydczid	208	6	ultrasound	ultrasound	NN
cord-253295-82ydczid	208	7	technology	technology	NN
cord-253295-82ydczid	208	8	allowed	allow	VBD
cord-253295-82ydczid	208	9	visualization	visualization	NN
cord-253295-82ydczid	208	10	of	of	IN
cord-253295-82ydczid	208	11	tissue	tissue	NN
cord-253295-82ydczid	208	12	with	with	IN
cord-253295-82ydczid	208	13	density	density	NN
cord-253295-82ydczid	208	14	differences	difference	NNS
cord-253295-82ydczid	208	15	,	,	,
cord-253295-82ydczid	208	16	such	such	JJ
cord-253295-82ydczid	208	17	as	as	IN
cord-253295-82ydczid	208	18	a	a	DT
cord-253295-82ydczid	208	19	developing	develop	VBG
cord-253295-82ydczid	208	20	fetus	fetus	NN
cord-253295-82ydczid	208	21	or	or	CC
cord-253295-82ydczid	208	22	gallbladder	gallbladder	NN
cord-253295-82ydczid	208	23	stones	stone	NNS
cord-253295-82ydczid	208	24	.	.	.
cord-253295-82ydczid	209	1	More	more	RBR
cord-253295-82ydczid	209	2	recently	recently	RB
cord-253295-82ydczid	209	3	,	,	,
cord-253295-82ydczid	209	4	physiology	physiology	NN
cord-253295-82ydczid	209	5	of	of	IN
cord-253295-82ydczid	209	6	neoplasms	neoplasm	NNS
cord-253295-82ydczid	209	7	can	can	MD
cord-253295-82ydczid	209	8	be	be	VB
cord-253295-82ydczid	209	9	screened	screen	VBN
cord-253295-82ydczid	209	10	with	with	IN
cord-253295-82ydczid	209	11	positron	positron	NN
cord-253295-82ydczid	209	12	emission	emission	NN
cord-253295-82ydczid	209	13	tomography	tomography	NN
cord-253295-82ydczid	209	14	(	(	-LRB-
cord-253295-82ydczid	209	15	PET	pet	NN
cord-253295-82ydczid	209	16	,	,	,
cord-253295-82ydczid	209	17	1977	1977	CD
cord-253295-82ydczid	209	18	)	)	-RRB-
cord-253295-82ydczid	209	19	for	for	IN
cord-253295-82ydczid	209	20	decay	decay	NN
cord-253295-82ydczid	209	21	of	of	IN
cord-253295-82ydczid	209	22	short	short	JJ
cord-253295-82ydczid	209	23	half	half	JJ
cord-253295-82ydczid	209	24	-	-	HYPH
cord-253295-82ydczid	209	25	life	life	NN
cord-253295-82ydczid	209	26	isotopes	isotope	NNS
cord-253295-82ydczid	209	27	such	such	JJ
cord-253295-82ydczid	209	28	as	as	IN
cord-253295-82ydczid	209	29	fluorodeoxyglucose	fluorodeoxyglucose	JJ
cord-253295-82ydczid	209	30	.	.	.
cord-253295-82ydczid	210	1	Neoplasms	neoplasm	NNS
cord-253295-82ydczid	210	2	with	with	IN
cord-253295-82ydczid	210	3	high	high	JJ
cord-253295-82ydczid	210	4	metabolism	metabolism	NN
cord-253295-82ydczid	210	5	can	can	MD
cord-253295-82ydczid	210	6	be	be	VB
cord-253295-82ydczid	210	7	distinguished	distinguish	VBN
cord-253295-82ydczid	210	8	physiologically	physiologically	RB
cord-253295-82ydczid	210	9	from	from	IN
cord-253295-82ydczid	210	10	adjacent	adjacent	JJ
cord-253295-82ydczid	210	11	lowmetabolism	lowmetabolism	NN
cord-253295-82ydczid	210	12	tissues	tissue	NNS
cord-253295-82ydczid	210	13	,	,	,
cord-253295-82ydczid	210	14	and	and	CC
cord-253295-82ydczid	210	15	can	can	MD
cord-253295-82ydczid	210	16	be	be	VB
cord-253295-82ydczid	210	17	localized	localize	VBN
cord-253295-82ydczid	210	18	with	with	IN
cord-253295-82ydczid	210	19	respect	respect	NN
cord-253295-82ydczid	210	20	to	to	IN
cord-253295-82ydczid	210	21	normal	normal	JJ
cord-253295-82ydczid	210	22	tissues	tissue	NNS
cord-253295-82ydczid	210	23	by	by	IN
cord-253295-82ydczid	210	24	pairing	pair	VBG
cord-253295-82ydczid	210	25	PET	pet	NN
cord-253295-82ydczid	210	26	with	with	IN
cord-253295-82ydczid	210	27	standard	standard	JJ
cord-253295-82ydczid	210	28	CT	CT	NNP
cord-253295-82ydczid	210	29	.	.	.
cord-253295-82ydczid	211	1	The	the	DT
cord-253295-82ydczid	211	2	result	result	NN
cord-253295-82ydczid	211	3	is	be	VBZ
cord-253295-82ydczid	211	4	an	an	DT
cord-253295-82ydczid	211	5	astonishingly	astonishingly	RB
cord-253295-82ydczid	211	6	useful	useful	JJ
cord-253295-82ydczid	211	7	means	mean	NNS
cord-253295-82ydczid	211	8	of	of	IN
cord-253295-82ydczid	211	9	identifying	identify	VBG
cord-253295-82ydczid	211	10	and	and	CC
cord-253295-82ydczid	211	11	localizing	localize	VBG
cord-253295-82ydczid	211	12	new	new	JJ
cord-253295-82ydczid	211	13	space	space	NN
cord-253295-82ydczid	211	14	-	-	HYPH
cord-253295-82ydczid	211	15	occupying	occupy	VBG
cord-253295-82ydczid	211	16	masses	masse	NNS
cord-253295-82ydczid	211	17	,	,	,
cord-253295-82ydczid	211	18	assigning	assign	VBG
cord-253295-82ydczid	211	19	a	a	DT
cord-253295-82ydczid	211	20	risk	risk	NN
cord-253295-82ydczid	211	21	for	for	IN
cord-253295-82ydczid	211	22	malignant	malignant	JJ
cord-253295-82ydczid	211	23	behavior	behavior	NN
cord-253295-82ydczid	211	24	and	and	CC
cord-253295-82ydczid	211	25	,	,	,
cord-253295-82ydczid	211	26	if	if	IN
cord-253295-82ydczid	211	27	malignant	malignant	JJ
cord-253295-82ydczid	211	28	,	,	,
cord-253295-82ydczid	211	29	screening	screen	VBG
cord-253295-82ydczid	211	30	for	for	IN
cord-253295-82ydczid	211	31	metastases	metastasis	NNS
cord-253295-82ydczid	211	32	in	in	IN
cord-253295-82ydczid	211	33	distant	distant	JJ
cord-253295-82ydczid	211	34	sites	site	NNS
cord-253295-82ydczid	211	35	.	.	.
cord-253295-82ydczid	212	1	This	this	DT
cord-253295-82ydczid	212	2	technique	technique	NN
cord-253295-82ydczid	212	3	is	be	VBZ
cord-253295-82ydczid	212	4	revolutionizing	revolutionize	VBG
cord-253295-82ydczid	212	5	the	the	DT
cord-253295-82ydczid	212	6	preoperative	preoperative	JJ
cord-253295-82ydczid	212	7	decision	decision	NN
cord-253295-82ydczid	212	8	-	-	HYPH
cord-253295-82ydczid	212	9	making	making	NN
cord-253295-82ydczid	212	10	of	of	IN
cord-253295-82ydczid	212	11	clinical	clinical	JJ
cord-253295-82ydczid	212	12	teams	team	NNS
cord-253295-82ydczid	212	13	,	,	,
cord-253295-82ydczid	212	14	and	and	CC
cord-253295-82ydczid	212	15	improves	improve	VBZ
cord-253295-82ydczid	212	16	the	the	DT
cord-253295-82ydczid	212	17	likelihood	likelihood	NN
cord-253295-82ydczid	212	18	that	that	IN
cord-253295-82ydczid	212	19	patients	patient	NNS
cord-253295-82ydczid	212	20	undergo	undergo	VBP
cord-253295-82ydczid	212	21	resections	resection	NNS
cord-253295-82ydczid	212	22	of	of	IN
cord-253295-82ydczid	212	23	new	new	JJ
cord-253295-82ydczid	212	24	mass	mass	JJ
cord-253295-82ydczid	212	25	lesions	lesion	NNS
cord-253295-82ydczid	212	26	only	only	RB
cord-253295-82ydczid	212	27	when	when	WRB
cord-253295-82ydczid	212	28	at	at	IN
cord-253295-82ydczid	212	29	risk	risk	NN
cord-253295-82ydczid	212	30	for	for	IN
cord-253295-82ydczid	212	31	morbidity	morbidity	NN
cord-253295-82ydczid	212	32	from	from	IN
cord-253295-82ydczid	212	33	malignant	malignant	JJ
cord-253295-82ydczid	212	34	behavior	behavior	NN
cord-253295-82ydczid	212	35	or	or	CC
cord-253295-82ydczid	212	36	interference	interference	NN
cord-253295-82ydczid	212	37	with	with	IN
cord-253295-82ydczid	212	38	normal	normal	JJ
cord-253295-82ydczid	212	39	function	function	NN
cord-253295-82ydczid	212	40	.	.	.
cord-253295-82ydczid	213	1	Pathologically	pathologically	RB
cord-253295-82ydczid	213	2	,	,	,
cord-253295-82ydczid	213	3	disease	disease	NN
cord-253295-82ydczid	213	4	is	be	VBZ
cord-253295-82ydczid	213	5	diagnosed	diagnose	VBN
cord-253295-82ydczid	213	6	by	by	IN
cord-253295-82ydczid	213	7	determining	determine	VBG
cord-253295-82ydczid	213	8	whether	whether	IN
cord-253295-82ydczid	213	9	the	the	DT
cord-253295-82ydczid	213	10	morphologic	morphologic	JJ
cord-253295-82ydczid	213	11	features	feature	NNS
cord-253295-82ydczid	213	12	match	match	VBP
cord-253295-82ydczid	213	13	the	the	DT
cord-253295-82ydczid	213	14	set	set	NN
cord-253295-82ydczid	213	15	of	of	IN
cord-253295-82ydczid	213	16	diagnostic	diagnostic	JJ
cord-253295-82ydczid	213	17	criteria	criterion	NNS
cord-253295-82ydczid	213	18	previously	previously	RB
cord-253295-82ydczid	213	19	described	describe	VBN
cord-253295-82ydczid	213	20	for	for	IN
cord-253295-82ydczid	213	21	each	each	DT
cord-253295-82ydczid	213	22	disease	disease	NN
cord-253295-82ydczid	213	23	.	.	.
cord-253295-82ydczid	214	1	Multivolume	multivolume	JJ
cord-253295-82ydczid	214	2	texts	text	NNS
cord-253295-82ydczid	214	3	are	be	VBP
cord-253295-82ydczid	214	4	devoted	devoted	JJ
cord-253295-82ydczid	214	5	to	to	IN
cord-253295-82ydczid	214	6	the	the	DT
cord-253295-82ydczid	214	7	gross	gross	JJ
cord-253295-82ydczid	214	8	and	and	CC
cord-253295-82ydczid	214	9	microscopic	microscopic	JJ
cord-253295-82ydczid	214	10	diagnostic	diagnostic	JJ
cord-253295-82ydczid	214	11	criteria	criterion	NNS
cord-253295-82ydczid	214	12	used	use	VBN
cord-253295-82ydczid	214	13	for	for	IN
cord-253295-82ydczid	214	14	diagnosis	diagnosis	NN
cord-253295-82ydczid	214	15	,	,	,
cord-253295-82ydczid	214	16	prognosis	prognosis	NN
cord-253295-82ydczid	214	17	,	,	,
cord-253295-82ydczid	214	18	and	and	CC
cord-253295-82ydczid	214	19	prediction	prediction	NN
cord-253295-82ydczid	214	20	of	of	IN
cord-253295-82ydczid	214	21	response	response	NN
cord-253295-82ydczid	214	22	to	to	IN
cord-253295-82ydczid	214	23	therapy	therapy	NN
cord-253295-82ydczid	214	24	.	.	.
cord-253295-82ydczid	215	1	Pathologists	pathologist	NNS
cord-253295-82ydczid	215	2	diagnose	diagnose	VBP
cord-253295-82ydczid	215	3	disease	disease	NN
cord-253295-82ydczid	215	4	by	by	IN
cord-253295-82ydczid	215	5	generating	generate	VBG
cord-253295-82ydczid	215	6	a	a	DT
cord-253295-82ydczid	215	7	differential	differential	JJ
cord-253295-82ydczid	215	8	diagnosis	diagnosis	NN
cord-253295-82ydczid	215	9	,	,	,
cord-253295-82ydczid	215	10	then	then	RB
cord-253295-82ydczid	215	11	finding	find	VBG
cord-253295-82ydczid	215	12	the	the	DT
cord-253295-82ydczid	215	13	best	good	JJS
cord-253295-82ydczid	215	14	fit	fit	NN
cord-253295-82ydczid	215	15	for	for	IN
cord-253295-82ydczid	215	16	the	the	DT
cord-253295-82ydczid	215	17	clinical	clinical	JJ
cord-253295-82ydczid	215	18	presentation	presentation	NN
cord-253295-82ydczid	215	19	,	,	,
cord-253295-82ydczid	215	20	the	the	DT
cord-253295-82ydczid	215	21	radiographic	radiographic	JJ
cord-253295-82ydczid	215	22	appearance	appearance	NN
cord-253295-82ydczid	215	23	,	,	,
cord-253295-82ydczid	215	24	and	and	CC
cord-253295-82ydczid	215	25	the	the	DT
cord-253295-82ydczid	215	26	pathologic	pathologic	JJ
cord-253295-82ydczid	215	27	(	(	-LRB-
cord-253295-82ydczid	215	28	both	both	DT
cord-253295-82ydczid	215	29	clinical	clinical	JJ
cord-253295-82ydczid	215	30	lab	lab	NN
cord-253295-82ydczid	215	31	and	and	CC
cord-253295-82ydczid	215	32	morphologic	morphologic	JJ
cord-253295-82ydczid	215	33	)	)	-RRB-
cord-253295-82ydczid	215	34	findings	finding	NNS
cord-253295-82ydczid	215	35	.	.	.
cord-253295-82ydczid	216	1	Logically	logically	RB
cord-253295-82ydczid	216	2	,	,	,
cord-253295-82ydczid	216	3	the	the	DT
cord-253295-82ydczid	216	4	Venn	Venn	NNP
cord-253295-82ydczid	216	5	diagram	diagram	NN
cord-253295-82ydczid	216	6	of	of	IN
cord-253295-82ydczid	216	7	the	the	DT
cord-253295-82ydczid	216	8	clinical	clinical	JJ
cord-253295-82ydczid	216	9	,	,	,
cord-253295-82ydczid	216	10	radiologic	radiologic	JJ
cord-253295-82ydczid	216	11	,	,	,
cord-253295-82ydczid	216	12	and	and	CC
cord-253295-82ydczid	216	13	pathologic	pathologic	JJ
cord-253295-82ydczid	216	14	differential	differential	JJ
cord-253295-82ydczid	216	15	diagnoses	diagnosis	NNS
cord-253295-82ydczid	216	16	should	should	MD
cord-253295-82ydczid	216	17	overlap	overlap	VB
cord-253295-82ydczid	216	18	.	.	.
cord-253295-82ydczid	217	1	Unexpected	unexpected	JJ
cord-253295-82ydczid	217	2	features	feature	NNS
cord-253295-82ydczid	217	3	expand	expand	VBP
cord-253295-82ydczid	217	4	the	the	DT
cord-253295-82ydczid	217	5	differential	differential	JJ
cord-253295-82ydczid	217	6	diagnosis	diagnosis	NN
cord-253295-82ydczid	217	7	and	and	CC
cord-253295-82ydczid	217	8	may	may	MD
cord-253295-82ydczid	217	9	raise	raise	VB
cord-253295-82ydczid	217	10	the	the	DT
cord-253295-82ydczid	217	11	possibility	possibility	NN
cord-253295-82ydczid	217	12	of	of	IN
cord-253295-82ydczid	217	13	previously	previously	RB
cord-253295-82ydczid	217	14	undescribed	undescribed	JJ
cord-253295-82ydczid	217	15	diseases	disease	NNS
cord-253295-82ydczid	217	16	.	.	.
cord-253295-82ydczid	218	1	For	for	IN
cord-253295-82ydczid	218	2	example	example	NN
cord-253295-82ydczid	218	3	,	,	,
cord-253295-82ydczid	218	4	Legionnaire	Legionnaire	NNP
cord-253295-82ydczid	218	5	's	's	POS
cord-253295-82ydczid	218	6	disease	disease	NN
cord-253295-82ydczid	218	7	,	,	,
cord-253295-82ydczid	218	8	human	human	JJ
cord-253295-82ydczid	218	9	immunodeficiency	immunodeficiency	NN
cord-253295-82ydczid	218	10	virus	virus	NN
cord-253295-82ydczid	218	11	(	(	-LRB-
cord-253295-82ydczid	218	12	HIV	HIV	NNP
cord-253295-82ydczid	218	13	)	)	-RRB-
cord-253295-82ydczid	218	14	,	,	,
cord-253295-82ydczid	218	15	Hantavirus	Hantavirus	NNP
cord-253295-82ydczid	218	16	pneumonia	pneumonia	NN
cord-253295-82ydczid	218	17	,	,	,
cord-253295-82ydczid	218	18	and	and	CC
cord-253295-82ydczid	218	19	severe	severe	JJ
cord-253295-82ydczid	218	20	acute	acute	JJ
cord-253295-82ydczid	218	21	respiratory	respiratory	JJ
cord-253295-82ydczid	218	22	syndrome	syndrome	NN
cord-253295-82ydczid	218	23	(	(	-LRB-
cord-253295-82ydczid	218	24	SARS	SARS	NNP
cord-253295-82ydczid	218	25	)	)	-RRB-
cord-253295-82ydczid	218	26	are	be	VBP
cord-253295-82ydczid	218	27	examples	example	NNS
cord-253295-82ydczid	218	28	of	of	IN
cord-253295-82ydczid	218	29	newly	newly	RB
cord-253295-82ydczid	218	30	described	describe	VBN
cord-253295-82ydczid	218	31	diagnoses	diagnosis	NNS
cord-253295-82ydczid	218	32	during	during	IN
cord-253295-82ydczid	218	33	the	the	DT
cord-253295-82ydczid	218	34	last	last	JJ
cord-253295-82ydczid	218	35	40	40	CD
cord-253295-82ydczid	218	36	years	year	NNS
cord-253295-82ydczid	218	37	.	.	.
cord-253295-82ydczid	219	1	The	the	DT
cord-253295-82ydczid	219	2	mental	mental	JJ
cord-253295-82ydczid	219	3	construct	construct	NN
cord-253295-82ydczid	219	4	of	of	IN
cord-253295-82ydczid	219	5	etiology	etiology	NN
cord-253295-82ydczid	219	6	(	(	-LRB-
cord-253295-82ydczid	219	7	cause	cause	NN
cord-253295-82ydczid	219	8	)	)	-RRB-
cord-253295-82ydczid	219	9	,	,	,
cord-253295-82ydczid	219	10	pathogenesis	pathogenesis	NN
cord-253295-82ydczid	219	11	(	(	-LRB-
cord-253295-82ydczid	219	12	progression	progression	NN
cord-253295-82ydczid	219	13	)	)	-RRB-
cord-253295-82ydczid	219	14	,	,	,
cord-253295-82ydczid	219	15	natural	natural	JJ
cord-253295-82ydczid	219	16	history	history	NN
cord-253295-82ydczid	219	17	(	(	-LRB-
cord-253295-82ydczid	219	18	clinical	clinical	JJ
cord-253295-82ydczid	219	19	outcome	outcome	NN
cord-253295-82ydczid	219	20	)	)	-RRB-
cord-253295-82ydczid	219	21	,	,	,
cord-253295-82ydczid	219	22	and	and	CC
cord-253295-82ydczid	219	23	response	response	NN
cord-253295-82ydczid	219	24	to	to	IN
cord-253295-82ydczid	219	25	therapy	therapy	NN
cord-253295-82ydczid	219	26	is	be	VBZ
cord-253295-82ydczid	219	27	the	the	DT
cord-253295-82ydczid	219	28	standard	standard	JJ
cord-253295-82ydczid	219	29	approach	approach	NN
cord-253295-82ydczid	219	30	for	for	IN
cord-253295-82ydczid	219	31	pathologists	pathologist	NNS
cord-253295-82ydczid	219	32	thinking	think	VBG
cord-253295-82ydczid	219	33	about	about	IN
cord-253295-82ydczid	219	34	a	a	DT
cord-253295-82ydczid	219	35	disease	disease	NN
cord-253295-82ydczid	219	36	.	.	.
cord-253295-82ydczid	220	1	A	a	DT
cord-253295-82ydczid	220	2	disease	disease	NN
cord-253295-82ydczid	220	3	may	may	MD
cord-253295-82ydczid	220	4	have	have	VB
cord-253295-82ydczid	220	5	one	one	CD
cord-253295-82ydczid	220	6	or	or	CC
cord-253295-82ydczid	220	7	more	more	JJR
cord-253295-82ydczid	220	8	etiologies	etiology	NNS
cord-253295-82ydczid	220	9	(	(	-LRB-
cord-253295-82ydczid	220	10	initial	initial	JJ
cord-253295-82ydczid	220	11	causes	cause	NNS
cord-253295-82ydczid	220	12	,	,	,
cord-253295-82ydczid	220	13	including	include	VBG
cord-253295-82ydczid	220	14	agents	agent	NNS
cord-253295-82ydczid	220	15	,	,	,
cord-253295-82ydczid	220	16	toxins	toxin	NNS
cord-253295-82ydczid	220	17	,	,	,
cord-253295-82ydczid	220	18	mutagens	mutagen	NNS
cord-253295-82ydczid	220	19	,	,	,
cord-253295-82ydczid	220	20	drugs	drug	NNS
cord-253295-82ydczid	220	21	,	,	,
cord-253295-82ydczid	220	22	allergens	allergen	NNS
cord-253295-82ydczid	220	23	,	,	,
cord-253295-82ydczid	220	24	trauma	trauma	NN
cord-253295-82ydczid	220	25	,	,	,
cord-253295-82ydczid	220	26	or	or	CC
cord-253295-82ydczid	220	27	genetic	genetic	JJ
cord-253295-82ydczid	220	28	mutations	mutation	NNS
cord-253295-82ydczid	220	29	)	)	-RRB-
cord-253295-82ydczid	220	30	.	.	.
cord-253295-82ydczid	221	1	A	a	DT
cord-253295-82ydczid	221	2	disease	disease	NN
cord-253295-82ydczid	221	3	is	be	VBZ
cord-253295-82ydczid	221	4	expected	expect	VBN
cord-253295-82ydczid	221	5	to	to	TO
cord-253295-82ydczid	221	6	follow	follow	VB
cord-253295-82ydczid	221	7	a	a	DT
cord-253295-82ydczid	221	8	particular	particular	JJ
cord-253295-82ydczid	221	9	series	series	NN
cord-253295-82ydczid	221	10	of	of	IN
cord-253295-82ydczid	221	11	events	event	NNS
cord-253295-82ydczid	221	12	in	in	IN
cord-253295-82ydczid	221	13	its	-PRON-	PRP$
cord-253295-82ydczid	221	14	development	development	NN
cord-253295-82ydczid	221	15	(	(	-LRB-
cord-253295-82ydczid	221	16	pathogenesis	pathogenesis	NN
cord-253295-82ydczid	221	17	)	)	-RRB-
cord-253295-82ydczid	221	18	,	,	,
cord-253295-82ydczid	221	19	and	and	CC
cord-253295-82ydczid	221	20	to	to	TO
cord-253295-82ydczid	221	21	follow	follow	VB
cord-253295-82ydczid	221	22	a	a	DT
cord-253295-82ydczid	221	23	particular	particular	JJ
cord-253295-82ydczid	221	24	clinical	clinical	JJ
cord-253295-82ydczid	221	25	course	course	NN
cord-253295-82ydczid	221	26	(	(	-LRB-
cord-253295-82ydczid	221	27	natural	natural	JJ
cord-253295-82ydczid	221	28	history	history	NN
cord-253295-82ydczid	221	29	)	)	-RRB-
cord-253295-82ydczid	221	30	.	.	.
cord-253295-82ydczid	222	1	Disease	Disease	NNP
cord-253295-82ydczid	222	2	can	can	MD
cord-253295-82ydczid	222	3	result	result	VB
cord-253295-82ydczid	222	4	in	in	IN
cord-253295-82ydczid	222	5	a	a	DT
cord-253295-82ydczid	222	6	temporary	temporary	JJ
cord-253295-82ydczid	222	7	or	or	CC
cord-253295-82ydczid	222	8	lasting	lasting	JJ
cord-253295-82ydczid	222	9	change	change	NN
cord-253295-82ydczid	222	10	in	in	IN
cord-253295-82ydczid	222	11	normal	normal	JJ
cord-253295-82ydczid	222	12	function	function	NN
cord-253295-82ydczid	222	13	,	,	,
cord-253295-82ydczid	222	14	including	include	VBG
cord-253295-82ydczid	222	15	patient	patient	JJ
cord-253295-82ydczid	222	16	death	death	NN
cord-253295-82ydczid	222	17	.	.	.
cord-253295-82ydczid	223	1	Multiple	multiple	JJ
cord-253295-82ydczid	223	2	diseases	disease	NNS
cord-253295-82ydczid	223	3	of	of	IN
cord-253295-82ydczid	223	4	different	different	JJ
cord-253295-82ydczid	223	5	etiologies	etiology	NNS
cord-253295-82ydczid	223	6	can	can	MD
cord-253295-82ydczid	223	7	affect	affect	VB
cord-253295-82ydczid	223	8	a	a	DT
cord-253295-82ydczid	223	9	single	single	JJ
cord-253295-82ydczid	223	10	organ	organ	NN
cord-253295-82ydczid	223	11	,	,	,
cord-253295-82ydczid	223	12	for	for	IN
cord-253295-82ydczid	223	13	example	example	NN
cord-253295-82ydczid	223	14	,	,	,
cord-253295-82ydczid	223	15	infectious	infectious	JJ
cord-253295-82ydczid	223	16	and	and	CC
cord-253295-82ydczid	223	17	neoplastic	neoplastic	JJ
cord-253295-82ydczid	223	18	diseases	disease	NNS
cord-253295-82ydczid	223	19	involving	involve	VBG
cord-253295-82ydczid	223	20	the	the	DT
cord-253295-82ydczid	223	21	lung	lung	NN
cord-253295-82ydczid	223	22	.	.	.
cord-253295-82ydczid	224	1	Different	different	JJ
cord-253295-82ydczid	224	2	diseases	disease	NNS
cord-253295-82ydczid	224	3	can	can	MD
cord-253295-82ydczid	224	4	derive	derive	VB
cord-253295-82ydczid	224	5	from	from	IN
cord-253295-82ydczid	224	6	a	a	DT
cord-253295-82ydczid	224	7	single	single	JJ
cord-253295-82ydczid	224	8	etiology	etiology	NN
cord-253295-82ydczid	224	9	,	,	,
cord-253295-82ydczid	224	10	for	for	IN
cord-253295-82ydczid	224	11	example	example	NN
cord-253295-82ydczid	224	12	,	,	,
cord-253295-82ydczid	224	13	emphysema	emphysema	NN
cord-253295-82ydczid	224	14	,	,	,
cord-253295-82ydczid	224	15	chronic	chronic	JJ
cord-253295-82ydczid	224	16	bronchitis	bronchitis	NN
cord-253295-82ydczid	224	17	,	,	,
cord-253295-82ydczid	224	18	and	and	CC
cord-253295-82ydczid	224	19	small	small	JJ
cord-253295-82ydczid	224	20	cell	cell	NN
cord-253295-82ydczid	224	21	lung	lung	NN
cord-253295-82ydczid	224	22	carcinoma	carcinoma	NN
cord-253295-82ydczid	224	23	in	in	IN
cord-253295-82ydczid	224	24	long	long	JJ
cord-253295-82ydczid	224	25	-	-	HYPH
cord-253295-82ydczid	224	26	term	term	NN
cord-253295-82ydczid	224	27	smokers	smoker	NNS
cord-253295-82ydczid	224	28	.	.	.
cord-253295-82ydczid	225	1	The	the	DT
cord-253295-82ydczid	225	2	same	same	JJ
cord-253295-82ydczid	225	3	disease	disease	NN
cord-253295-82ydczid	225	4	(	(	-LRB-
cord-253295-82ydczid	225	5	for	for	IN
cord-253295-82ydczid	225	6	instance	instance	NN
cord-253295-82ydczid	225	7	,	,	,
cord-253295-82ydczid	225	8	emphysema	emphysema	NN
cord-253295-82ydczid	225	9	of	of	IN
cord-253295-82ydczid	225	10	the	the	DT
cord-253295-82ydczid	225	11	lung	lung	NN
cord-253295-82ydczid	225	12	)	)	-RRB-
cord-253295-82ydczid	225	13	can	can	MD
cord-253295-82ydczid	225	14	derive	derive	VB
cord-253295-82ydczid	225	15	from	from	IN
cord-253295-82ydczid	225	16	different	different	JJ
cord-253295-82ydczid	225	17	etiologies	etiology	NNS
cord-253295-82ydczid	225	18	(	(	-LRB-
cord-253295-82ydczid	225	19	emphysema	emphysema	NN
cord-253295-82ydczid	225	20	from	from	IN
cord-253295-82ydczid	225	21	α-1-antitrypsin	α-1-antitrypsin	DT
cord-253295-82ydczid	225	22	deficiency	deficiency	NN
cord-253295-82ydczid	225	23	or	or	CC
cord-253295-82ydczid	225	24	cigarette	cigarette	NN
cord-253295-82ydczid	225	25	smoke	smoke	NN
cord-253295-82ydczid	225	26	)	)	-RRB-
cord-253295-82ydczid	225	27	.	.	.
cord-253295-82ydczid	226	1	Modern	modern	JJ
cord-253295-82ydczid	226	2	surgical	surgical	JJ
cord-253295-82ydczid	226	3	pathology	pathology	NN
cord-253295-82ydczid	226	4	practice	practice	NN
cord-253295-82ydczid	226	5	hinges	hinge	NNS
cord-253295-82ydczid	226	6	on	on	IN
cord-253295-82ydczid	226	7	morphologic	morphologic	JJ
cord-253295-82ydczid	226	8	diagnosis	diagnosis	NN
cord-253295-82ydczid	226	9	,	,	,
cord-253295-82ydczid	226	10	supplemented	supplement	VBN
cord-253295-82ydczid	226	11	by	by	IN
cord-253295-82ydczid	226	12	special	special	JJ
cord-253295-82ydczid	226	13	stains	stain	NNS
cord-253295-82ydczid	226	14	,	,	,
cord-253295-82ydczid	226	15	immunohistochemical	immunohistochemical	JJ
cord-253295-82ydczid	226	16	stains	stain	NNS
cord-253295-82ydczid	226	17	,	,	,
cord-253295-82ydczid	226	18	cytogenetic	cytogenetic	JJ
cord-253295-82ydczid	226	19	/	/	SYM
cord-253295-82ydczid	226	20	molecular	molecular	JJ
cord-253295-82ydczid	226	21	data	datum	NNS
cord-253295-82ydczid	226	22	,	,	,
cord-253295-82ydczid	226	23	and	and	CC
cord-253295-82ydczid	226	24	other	other	JJ
cord-253295-82ydczid	226	25	clinical	clinical	JJ
cord-253295-82ydczid	226	26	laboratory	laboratory	NN
cord-253295-82ydczid	226	27	findings	finding	NNS
cord-253295-82ydczid	226	28	,	,	,
cord-253295-82ydczid	226	29	as	as	RB
cord-253295-82ydczid	226	30	well	well	RB
cord-253295-82ydczid	226	31	as	as	IN
cord-253295-82ydczid	226	32	on	on	IN
cord-253295-82ydczid	226	33	the	the	DT
cord-253295-82ydczid	226	34	clinical	clinical	JJ
cord-253295-82ydczid	226	35	and	and	CC
cord-253295-82ydczid	226	36	radiographic	radiographic	JJ
cord-253295-82ydczid	226	37	findings	finding	NNS
cord-253295-82ydczid	226	38	.	.	.
cord-253295-82ydczid	227	1	Findings	finding	NNS
cord-253295-82ydczid	227	2	that	that	WDT
cord-253295-82ydczid	227	3	meet	meet	VBP
cord-253295-82ydczid	227	4	all	all	DT
cord-253295-82ydczid	227	5	of	of	IN
cord-253295-82ydczid	227	6	these	these	DT
cord-253295-82ydczid	227	7	criteria	criterion	NNS
cord-253295-82ydczid	227	8	are	be	VBP
cord-253295-82ydczid	227	9	diagnostic	diagnostic	JJ
cord-253295-82ydczid	227	10	for	for	IN
cord-253295-82ydczid	227	11	the	the	DT
cord-253295-82ydczid	227	12	disease	disease	NN
cord-253295-82ydczid	227	13	.	.	.
cord-253295-82ydczid	228	1	If	if	IN
cord-253295-82ydczid	228	2	some	some	DT
cord-253295-82ydczid	228	3	,	,	,
cord-253295-82ydczid	228	4	but	but	CC
cord-253295-82ydczid	228	5	not	not	RB
cord-253295-82ydczid	228	6	all	all	DT
cord-253295-82ydczid	228	7	,	,	,
cord-253295-82ydczid	228	8	of	of	IN
cord-253295-82ydczid	228	9	the	the	DT
cord-253295-82ydczid	228	10	criteria	criterion	NNS
cord-253295-82ydczid	228	11	are	be	VBP
cord-253295-82ydczid	228	12	present	present	JJ
cord-253295-82ydczid	228	13	to	to	TO
cord-253295-82ydczid	228	14	make	make	VB
cord-253295-82ydczid	228	15	a	a	DT
cord-253295-82ydczid	228	16	definitive	definitive	JJ
cord-253295-82ydczid	228	17	diagnosis	diagnosis	NN
cord-253295-82ydczid	228	18	,	,	,
cord-253295-82ydczid	228	19	the	the	DT
cord-253295-82ydczid	228	20	pathologist	pathologist	NN
cord-253295-82ydczid	228	21	must	must	MD
cord-253295-82ydczid	228	22	either	either	CC
cord-253295-82ydczid	228	23	equivocate	equivocate	VB
cord-253295-82ydczid	228	24	or	or	CC
cord-253295-82ydczid	228	25	make	make	VB
cord-253295-82ydczid	228	26	an	an	DT
cord-253295-82ydczid	228	27	alternate	alternate	JJ
cord-253295-82ydczid	228	28	diagnosis	diagnosis	NN
cord-253295-82ydczid	228	29	.	.	.
cord-253295-82ydczid	229	1	Thus	thus	RB
cord-253295-82ydczid	229	2	,	,	,
cord-253295-82ydczid	229	3	a	a	DT
cord-253295-82ydczid	229	4	firm	firm	JJ
cord-253295-82ydczid	229	5	grasp	grasp	NN
cord-253295-82ydczid	229	6	of	of	IN
cord-253295-82ydczid	229	7	the	the	DT
cord-253295-82ydczid	229	8	diagnostic	diagnostic	JJ
cord-253295-82ydczid	229	9	criteria	criterion	NNS
cord-253295-82ydczid	229	10	,	,	,
cord-253295-82ydczid	229	11	and	and	CC
cord-253295-82ydczid	229	12	the	the	DT
cord-253295-82ydczid	229	13	instincts	instinct	NNS
cord-253295-82ydczid	229	14	to	to	TO
cord-253295-82ydczid	229	15	rapidly	rapidly	RB
cord-253295-82ydczid	229	16	create	create	VB
cord-253295-82ydczid	229	17	and	and	CC
cord-253295-82ydczid	229	18	sort	sort	VB
cord-253295-82ydczid	229	19	through	through	IN
cord-253295-82ydczid	229	20	the	the	DT
cord-253295-82ydczid	229	21	differential	differential	JJ
cord-253295-82ydczid	229	22	diagnosis	diagnosis	NN
cord-253295-82ydczid	229	23	,	,	,
cord-253295-82ydczid	229	24	must	must	MD
cord-253295-82ydczid	229	25	be	be	VB
cord-253295-82ydczid	229	26	possessed	possess	VBN
cord-253295-82ydczid	229	27	by	by	IN
cord-253295-82ydczid	229	28	the	the	DT
cord-253295-82ydczid	229	29	service	service	NN
cord-253295-82ydczid	229	30	pathologist	pathologist	NN
cord-253295-82ydczid	229	31	.	.	.
cord-253295-82ydczid	230	1	The	the	DT
cord-253295-82ydczid	230	2	tissue	tissue	NN
cord-253295-82ydczid	230	3	diagnosis	diagnosis	NN
cord-253295-82ydczid	230	4	has	have	VBZ
cord-253295-82ydczid	230	5	to	to	TO
cord-253295-82ydczid	230	6	make	make	VB
cord-253295-82ydczid	230	7	sense	sense	NN
cord-253295-82ydczid	230	8	,	,	,
cord-253295-82ydczid	230	9	not	not	RB
cord-253295-82ydczid	230	10	only	only	RB
cord-253295-82ydczid	230	11	from	from	IN
cord-253295-82ydczid	230	12	the	the	DT
cord-253295-82ydczid	230	13	morphologic	morphologic	JJ
cord-253295-82ydczid	230	14	perspective	perspective	NN
cord-253295-82ydczid	230	15	,	,	,
cord-253295-82ydczid	230	16	but	but	CC
cord-253295-82ydczid	230	17	from	from	IN
cord-253295-82ydczid	230	18	the	the	DT
cord-253295-82ydczid	230	19	clinical	clinical	JJ
cord-253295-82ydczid	230	20	and	and	CC
cord-253295-82ydczid	230	21	radiographic	radiographic	JJ
cord-253295-82ydczid	230	22	vantage	vantage	NN
cord-253295-82ydczid	230	23	points	point	NNS
cord-253295-82ydczid	230	24	as	as	RB
cord-253295-82ydczid	230	25	well	well	RB
cord-253295-82ydczid	230	26	.	.	.
cord-253295-82ydczid	231	1	It	-PRON-	PRP
cord-253295-82ydczid	231	2	is	be	VBZ
cord-253295-82ydczid	231	3	both	both	DT
cord-253295-82ydczid	231	4	legally	legally	RB
cord-253295-82ydczid	231	5	risky	risky	JJ
cord-253295-82ydczid	231	6	and	and	CC
cord-253295-82ydczid	231	7	professionally	professionally	RB
cord-253295-82ydczid	231	8	erosive	erosive	JJ
cord-253295-82ydczid	231	9	to	to	TO
cord-253295-82ydczid	231	10	make	make	VB
cord-253295-82ydczid	231	11	a	a	DT
cord-253295-82ydczid	231	12	clinically	clinically	RB
cord-253295-82ydczid	231	13	and	and	CC
cord-253295-82ydczid	231	14	pathologically	pathologically	RB
cord-253295-82ydczid	231	15	impossible	impossible	JJ
cord-253295-82ydczid	231	16	diagnosis	diagnosis	NN
cord-253295-82ydczid	231	17	.	.	.
cord-253295-82ydczid	232	1	In	in	IN
cord-253295-82ydczid	232	2	the	the	DT
cord-253295-82ydczid	232	3	recent	recent	JJ
cord-253295-82ydczid	232	4	past	past	NN
cord-253295-82ydczid	232	5	,	,	,
cord-253295-82ydczid	232	6	limited	limited	JJ
cord-253295-82ydczid	232	7	computer	computer	NN
cord-253295-82ydczid	232	8	networking	networking	NN
cord-253295-82ydczid	232	9	meant	mean	VBD
cord-253295-82ydczid	232	10	numerous	numerous	JJ
cord-253295-82ydczid	232	11	phone	phone	NN
cord-253295-82ydczid	232	12	calls	call	NNS
cord-253295-82ydczid	232	13	to	to	TO
cord-253295-82ydczid	232	14	gather	gather	VB
cord-253295-82ydczid	232	15	the	the	DT
cord-253295-82ydczid	232	16	relevant	relevant	JJ
cord-253295-82ydczid	232	17	clinical	clinical	JJ
cord-253295-82ydczid	232	18	and	and	CC
cord-253295-82ydczid	232	19	radiographic	radiographic	JJ
cord-253295-82ydczid	232	20	information	information	NN
cord-253295-82ydczid	232	21	to	to	TO
cord-253295-82ydczid	232	22	make	make	VB
cord-253295-82ydczid	232	23	an	an	DT
cord-253295-82ydczid	232	24	informed	informed	JJ
cord-253295-82ydczid	232	25	morphologic	morphologic	JJ
cord-253295-82ydczid	232	26	diagnosis	diagnosis	NN
cord-253295-82ydczid	232	27	.	.	.
cord-253295-82ydczid	233	1	For	for	IN
cord-253295-82ydczid	233	2	example	example	NN
cord-253295-82ydczid	233	3	,	,	,
cord-253295-82ydczid	233	4	certain	certain	JJ
cord-253295-82ydczid	233	5	diseases	disease	NNS
cord-253295-82ydczid	233	6	such	such	JJ
cord-253295-82ydczid	233	7	as	as	IN
cord-253295-82ydczid	233	8	squamous	squamous	JJ
cord-253295-82ydczid	233	9	and	and	CC
cord-253295-82ydczid	233	10	small	small	JJ
cord-253295-82ydczid	233	11	cell	cell	NN
cord-253295-82ydczid	233	12	carcinomas	carcinoma	NNS
cord-253295-82ydczid	233	13	of	of	IN
cord-253295-82ydczid	233	14	the	the	DT
cord-253295-82ydczid	233	15	lung	lung	NN
cord-253295-82ydczid	233	16	are	be	VBP
cord-253295-82ydczid	233	17	extremely	extremely	RB
cord-253295-82ydczid	233	18	rare	rare	JJ
cord-253295-82ydczid	233	19	in	in	IN
cord-253295-82ydczid	233	20	non	non	NNS
cord-253295-82ydczid	233	21	-	-	NNS
cord-253295-82ydczid	233	22	smokers	smoker	NNS
cord-253295-82ydczid	233	23	.	.	.
cord-253295-82ydczid	234	1	Thus	thus	RB
cord-253295-82ydczid	234	2	,	,	,
cord-253295-82ydczid	234	3	a	a	DT
cord-253295-82ydczid	234	4	small	small	JJ
cord-253295-82ydczid	234	5	cell	cell	NN
cord-253295-82ydczid	234	6	carcinoma	carcinoma	NN
cord-253295-82ydczid	234	7	in	in	IN
cord-253295-82ydczid	234	8	the	the	DT
cord-253295-82ydczid	234	9	lung	lung	NN
cord-253295-82ydczid	234	10	of	of	IN
cord-253295-82ydczid	234	11	a	a	DT
cord-253295-82ydczid	234	12	non	non	JJ
cord-253295-82ydczid	234	13	-	-	JJ
cord-253295-82ydczid	234	14	smoker	smoker	JJ
cord-253295-82ydczid	234	15	merits	merit	NNS
cord-253295-82ydczid	234	16	screening	screen	VBG
cord-253295-82ydczid	234	17	for	for	IN
cord-253295-82ydczid	234	18	a	a	DT
cord-253295-82ydczid	234	19	non	non	JJ
cord-253295-82ydczid	234	20	-	-	JJ
cord-253295-82ydczid	234	21	pulmonary	pulmonary	JJ
cord-253295-82ydczid	234	22	primary	primary	JJ
cord-253295-82ydczid	234	23	site	site	NN
cord-253295-82ydczid	234	24	.	.	.
cord-253295-82ydczid	235	1	Fortunately	fortunately	RB
cord-253295-82ydczid	235	2	for	for	IN
cord-253295-82ydczid	235	3	pathologists	pathologist	NNS
cord-253295-82ydczid	235	4	,	,	,
cord-253295-82ydczid	235	5	computing	computing	NN
cord-253295-82ydczid	235	6	and	and	CC
cord-253295-82ydczid	235	7	networking	networking	NN
cord-253295-82ydczid	235	8	technologies	technology	NNS
cord-253295-82ydczid	235	9	now	now	RB
cord-253295-82ydczid	235	10	allow	allow	VBP
cord-253295-82ydczid	235	11	access	access	NN
cord-253295-82ydczid	235	12	to	to	IN
cord-253295-82ydczid	235	13	preoperative	preoperative	JJ
cord-253295-82ydczid	235	14	clinical	clinical	JJ
cord-253295-82ydczid	235	15	workups	workup	NNS
cord-253295-82ydczid	235	16	,	,	,
cord-253295-82ydczid	235	17	radiographs	radiograph	NNS
cord-253295-82ydczid	235	18	/	/	SYM
cord-253295-82ydczid	235	19	reports	report	NNS
cord-253295-82ydczid	235	20	,	,	,
cord-253295-82ydczid	235	21	clinical	clinical	JJ
cord-253295-82ydczid	235	22	laboratory	laboratory	NN
cord-253295-82ydczid	235	23	data	datum	NNS
cord-253295-82ydczid	235	24	,	,	,
cord-253295-82ydczid	235	25	and	and	CC
cord-253295-82ydczid	235	26	prior	prior	JJ
cord-253295-82ydczid	235	27	pathology	pathology	NN
cord-253295-82ydczid	235	28	reports	report	NNS
cord-253295-82ydczid	235	29	.	.	.
cord-253295-82ydczid	236	1	All	all	DT
cord-253295-82ydczid	236	2	of	of	IN
cord-253295-82ydczid	236	3	these	these	DT
cord-253295-82ydczid	236	4	data	datum	NNS
cord-253295-82ydczid	236	5	protect	protect	VBP
cord-253295-82ydczid	236	6	pathologists	pathologist	NNS
cord-253295-82ydczid	236	7	by	by	IN
cord-253295-82ydczid	236	8	providing	provide	VBG
cord-253295-82ydczid	236	9	them	-PRON-	PRP
cord-253295-82ydczid	236	10	with	with	IN
cord-253295-82ydczid	236	11	the	the	DT
cord-253295-82ydczid	236	12	relevant	relevant	JJ
cord-253295-82ydczid	236	13	clinical	clinical	JJ
cord-253295-82ydczid	236	14	and	and	CC
cord-253295-82ydczid	236	15	radiographic	radiographic	JJ
cord-253295-82ydczid	236	16	information	information	NN
cord-253295-82ydczid	236	17	,	,	,
cord-253295-82ydczid	236	18	and	and	CC
cord-253295-82ydczid	236	19	protect	protect	VB
cord-253295-82ydczid	236	20	patients	patient	NNS
cord-253295-82ydczid	236	21	by	by	IN
cord-253295-82ydczid	236	22	improving	improve	VBG
cord-253295-82ydczid	236	23	diagnostic	diagnostic	JJ
cord-253295-82ydczid	236	24	accuracy	accuracy	NN
cord-253295-82ydczid	236	25	.	.	.
cord-253295-82ydczid	237	1	Just	just	RB
cord-253295-82ydczid	237	2	as	as	IN
cord-253295-82ydczid	237	3	research	research	NN
cord-253295-82ydczid	237	4	scientists	scientist	NNS
cord-253295-82ydczid	237	5	"	"	''
cord-253295-82ydczid	237	6	.	.	.
cord-253295-82ydczid	237	7	.	.	.
cord-253295-82ydczid	237	8	.	.	.
cord-253295-82ydczid	238	1	ignore	ignore	VB
cord-253295-82ydczid	238	2	the	the	DT
cord-253295-82ydczid	238	3	literature	literature	NN
cord-253295-82ydczid	238	4	at	at	IN
cord-253295-82ydczid	238	5	their	-PRON-	PRP$
cord-253295-82ydczid	238	6	peril	peril	NN
cord-253295-82ydczid	238	7	.	.	.
cord-253295-82ydczid	238	8	.	.	.
cord-253295-82ydczid	238	9	.	.	.
cord-253295-82ydczid	239	1	"	"	``
cord-253295-82ydczid	239	2	,	,	,
cord-253295-82ydczid	239	3	diagnostic	diagnostic	JJ
cord-253295-82ydczid	239	4	pathologists	pathologist	NNS
cord-253295-82ydczid	239	5	"	"	''
cord-253295-82ydczid	239	6	.	.	.
cord-253295-82ydczid	239	7	.	.	.
cord-253295-82ydczid	239	8	.	.	.
cord-253295-82ydczid	240	1	ignore	ignore	VB
cord-253295-82ydczid	240	2	the	the	DT
cord-253295-82ydczid	240	3	presentation	presentation	NN
cord-253295-82ydczid	240	4	,	,	,
cord-253295-82ydczid	240	5	past	past	IN
cord-253295-82ydczid	240	6	history	history	NN
cord-253295-82ydczid	240	7	,	,	,
cord-253295-82ydczid	240	8	workup	workup	NN
cord-253295-82ydczid	240	9	,	,	,
cord-253295-82ydczid	240	10	prior	prior	JJ
cord-253295-82ydczid	240	11	biopsies	biopsy	NNS
cord-253295-82ydczid	240	12	,	,	,
cord-253295-82ydczid	240	13	and	and	CC
cord-253295-82ydczid	240	14	radiographs	radiograph	NNS
cord-253295-82ydczid	240	15	at	at	IN
cord-253295-82ydczid	240	16	their	-PRON-	PRP$
cord-253295-82ydczid	240	17	peril	peril	NN
cord-253295-82ydczid	240	18	.	.	.
cord-253295-82ydczid	240	19	.	.	.
cord-253295-82ydczid	240	20	.	.	.
cord-253295-82ydczid	241	1	"	"	``
cord-253295-82ydczid	241	2	There	there	EX
cord-253295-82ydczid	241	3	are	be	VBP
cord-253295-82ydczid	241	4	limitations	limitation	NNS
cord-253295-82ydczid	241	5	to	to	IN
cord-253295-82ydczid	241	6	morphologic	morphologic	JJ
cord-253295-82ydczid	241	7	diagnosis	diagnosis	NN
cord-253295-82ydczid	241	8	by	by	IN
cord-253295-82ydczid	241	9	H&E	H&E	NNP
cord-253295-82ydczid	241	10	stains	stain	NNS
cord-253295-82ydczid	241	11	.	.	.
cord-253295-82ydczid	242	1	First	first	RB
cord-253295-82ydczid	242	2	,	,	,
cord-253295-82ydczid	242	3	lineage	lineage	NN
cord-253295-82ydczid	242	4	of	of	IN
cord-253295-82ydczid	242	5	certain	certain	JJ
cord-253295-82ydczid	242	6	classes	class	NNS
cord-253295-82ydczid	242	7	of	of	IN
cord-253295-82ydczid	242	8	neoplasms	neoplasm	NNS
cord-253295-82ydczid	242	9	(	(	-LRB-
cord-253295-82ydczid	242	10	including	include	VBG
cord-253295-82ydczid	242	11	small	small	JJ
cord-253295-82ydczid	242	12	round	round	JJ
cord-253295-82ydczid	242	13	blue	blue	JJ
cord-253295-82ydczid	242	14	cell	cell	NN
cord-253295-82ydczid	242	15	tumors	tumor	NNS
cord-253295-82ydczid	242	16	,	,	,
cord-253295-82ydczid	242	17	clear	clear	JJ
cord-253295-82ydczid	242	18	cell	cell	NN
cord-253295-82ydczid	242	19	neoplasms	neoplasm	NNS
cord-253295-82ydczid	242	20	,	,	,
cord-253295-82ydczid	242	21	spindle	spindle	NN
cord-253295-82ydczid	242	22	cell	cell	NN
cord-253295-82ydczid	242	23	neoplasms	neoplasm	NNS
cord-253295-82ydczid	242	24	,	,	,
cord-253295-82ydczid	242	25	and	and	CC
cord-253295-82ydczid	242	26	undifferentiated	undifferentiated	JJ
cord-253295-82ydczid	242	27	malignant	malignant	JJ
cord-253295-82ydczid	242	28	neoplasms	neoplasm	NNS
cord-253295-82ydczid	242	29	)	)	-RRB-
cord-253295-82ydczid	242	30	is	be	VBZ
cord-253295-82ydczid	242	31	usually	usually	RB
cord-253295-82ydczid	242	32	clarified	clarify	VBN
cord-253295-82ydczid	242	33	by	by	IN
cord-253295-82ydczid	242	34	immunohistochemistry	immunohistochemistry	NN
cord-253295-82ydczid	242	35	,	,	,
cord-253295-82ydczid	242	36	frequently	frequently	RB
cord-253295-82ydczid	242	37	by	by	IN
cord-253295-82ydczid	242	38	cytogenetics	cytogenetic	NNS
cord-253295-82ydczid	242	39	(	(	-LRB-
cord-253295-82ydczid	242	40	when	when	WRB
cord-253295-82ydczid	242	41	performed	perform	VBN
cord-253295-82ydczid	242	42	)	)	-RRB-
cord-253295-82ydczid	242	43	,	,	,
cord-253295-82ydczid	242	44	and	and	CC
cord-253295-82ydczid	242	45	sometimes	sometimes	RB
cord-253295-82ydczid	242	46	by	by	IN
cord-253295-82ydczid	242	47	electron	electron	NN
cord-253295-82ydczid	242	48	microscopy	microscopy	NN
cord-253295-82ydczid	242	49	.	.	.
cord-253295-82ydczid	243	1	Second	second	RB
cord-253295-82ydczid	243	2	,	,	,
cord-253295-82ydczid	243	3	there	there	EX
cord-253295-82ydczid	243	4	are	be	VBP
cord-253295-82ydczid	243	5	limitations	limitation	NNS
cord-253295-82ydczid	243	6	inherent	inherent	JJ
cord-253295-82ydczid	243	7	in	in	IN
cord-253295-82ydczid	243	8	a	a	DT
cord-253295-82ydczid	243	9	snapshot	snapshot	JJ
cord-253295-82ydczid	243	10	biopsy	biopsy	NN
cord-253295-82ydczid	243	11	or	or	CC
cord-253295-82ydczid	243	12	resection	resection	NN
cord-253295-82ydczid	243	13	.	.	.
cord-253295-82ydczid	244	1	Thus	thus	RB
cord-253295-82ydczid	244	2	,	,	,
cord-253295-82ydczid	244	3	the	the	DT
cord-253295-82ydczid	244	4	etiology	etiology	NN
cord-253295-82ydczid	244	5	and	and	CC
cord-253295-82ydczid	244	6	pathogenesis	pathogenesis	NN
cord-253295-82ydczid	244	7	can	can	MD
cord-253295-82ydczid	244	8	be	be	VB
cord-253295-82ydczid	244	9	obscure	obscure	JJ
cord-253295-82ydczid	244	10	or	or	CC
cord-253295-82ydczid	244	11	indeterminate	indeterminate	JJ
cord-253295-82ydczid	244	12	,	,	,
cord-253295-82ydczid	244	13	and	and	CC
cord-253295-82ydczid	244	14	rates	rate	NNS
cord-253295-82ydczid	244	15	of	of	IN
cord-253295-82ydczid	244	16	growth	growth	NN
cord-253295-82ydczid	244	17	,	,	,
cord-253295-82ydczid	244	18	invasion	invasion	NN
cord-253295-82ydczid	244	19	,	,	,
cord-253295-82ydczid	244	20	or	or	CC
cord-253295-82ydczid	244	21	timing	timing	NN
cord-253295-82ydczid	244	22	of	of	IN
cord-253295-82ydczid	244	23	metastasis	metastasis	NN
cord-253295-82ydczid	244	24	can	can	MD
cord-253295-82ydczid	244	25	not	not	RB
cord-253295-82ydczid	244	26	be	be	VB
cord-253295-82ydczid	244	27	inferred	infer	VBN
cord-253295-82ydczid	244	28	.	.	.
cord-253295-82ydczid	245	1	Third	third	RB
cord-253295-82ydczid	245	2	,	,	,
cord-253295-82ydczid	245	3	the	the	DT
cord-253295-82ydczid	245	4	morphologic	morphologic	JJ
cord-253295-82ydczid	245	5	changes	change	NNS
cord-253295-82ydczid	245	6	may	may	MD
cord-253295-82ydczid	245	7	not	not	RB
cord-253295-82ydczid	245	8	be	be	VB
cord-253295-82ydczid	245	9	specific	specific	JJ
cord-253295-82ydczid	245	10	for	for	IN
cord-253295-82ydczid	245	11	the	the	DT
cord-253295-82ydczid	245	12	underlying	underlying	JJ
cord-253295-82ydczid	245	13	molecular	molecular	JJ
cord-253295-82ydczid	245	14	abnormalities	abnormality	NNS
cord-253295-82ydczid	245	15	,	,	,
cord-253295-82ydczid	245	16	particularly	particularly	RB
cord-253295-82ydczid	245	17	the	the	DT
cord-253295-82ydczid	245	18	ratelimiting	ratelimiting	NN
cord-253295-82ydczid	245	19	(	(	-LRB-
cord-253295-82ydczid	245	20	therapeutic	therapeutic	JJ
cord-253295-82ydczid	245	21	target	target	NN
cord-253295-82ydczid	245	22	)	)	-RRB-
cord-253295-82ydczid	245	23	step	step	NN
cord-253295-82ydczid	245	24	in	in	IN
cord-253295-82ydczid	245	25	the	the	DT
cord-253295-82ydczid	245	26	pathogenesis	pathogenesis	NN
cord-253295-82ydczid	245	27	of	of	IN
cord-253295-82ydczid	245	28	a	a	DT
cord-253295-82ydczid	245	29	neoplasm	neoplasm	NN
cord-253295-82ydczid	245	30	.	.	.
cord-253295-82ydczid	246	1	For	for	IN
cord-253295-82ydczid	246	2	example	example	NN
cord-253295-82ydczid	246	3	,	,	,
cord-253295-82ydczid	246	4	RET	ret	JJ
cord-253295-82ydczid	246	5	gain	gain	NN
cord-253295-82ydczid	246	6	of	of	IN
cord-253295-82ydczid	246	7	function	function	NN
cord-253295-82ydczid	246	8	mutations	mutation	NNS
cord-253295-82ydczid	246	9	in	in	IN
cord-253295-82ydczid	246	10	a	a	DT
cord-253295-82ydczid	246	11	medullary	medullary	JJ
cord-253295-82ydczid	246	12	thyroid	thyroid	NN
cord-253295-82ydczid	246	13	carcinoma	carcinoma	NN
cord-253295-82ydczid	246	14	will	will	MD
cord-253295-82ydczid	246	15	require	require	VB
cord-253295-82ydczid	246	16	DNA	dna	NN
cord-253295-82ydczid	246	17	level	level	NN
cord-253295-82ydczid	246	18	screening	screening	NN
cord-253295-82ydczid	246	19	to	to	TO
cord-253295-82ydczid	246	20	determine	determine	VB
cord-253295-82ydczid	246	21	germline	germline	JJ
cord-253295-82ydczid	246	22	involvement	involvement	NN
cord-253295-82ydczid	246	23	,	,	,
cord-253295-82ydczid	246	24	familial	familial	JJ
cord-253295-82ydczid	246	25	risk	risk	NN
cord-253295-82ydczid	246	26	,	,	,
cord-253295-82ydczid	246	27	and	and	CC
cord-253295-82ydczid	246	28	presence	presence	NN
cord-253295-82ydczid	246	29	or	or	CC
cord-253295-82ydczid	246	30	absence	absence	NN
cord-253295-82ydczid	246	31	of	of	IN
cord-253295-82ydczid	246	32	a	a	DT
cord-253295-82ydczid	246	33	therapeutic	therapeutic	JJ
cord-253295-82ydczid	246	34	target	target	NN
cord-253295-82ydczid	246	35	.	.	.
cord-253295-82ydczid	247	1	Fourth	fourth	RB
cord-253295-82ydczid	247	2	,	,	,
cord-253295-82ydczid	247	3	the	the	DT
cord-253295-82ydczid	247	4	same	same	JJ
cord-253295-82ydczid	247	5	morphologic	morphologic	JJ
cord-253295-82ydczid	247	6	appearance	appearance	NN
cord-253295-82ydczid	247	7	may	may	MD
cord-253295-82ydczid	247	8	be	be	VB
cord-253295-82ydczid	247	9	identical	identical	JJ
cord-253295-82ydczid	247	10	for	for	IN
cord-253295-82ydczid	247	11	two	two	CD
cord-253295-82ydczid	247	12	different	different	JJ
cord-253295-82ydczid	247	13	diseases	disease	NNS
cord-253295-82ydczid	247	14	,	,	,
cord-253295-82ydczid	247	15	each	each	DT
cord-253295-82ydczid	247	16	of	of	IN
cord-253295-82ydczid	247	17	which	which	WDT
cord-253295-82ydczid	247	18	would	would	MD
cord-253295-82ydczid	247	19	be	be	VB
cord-253295-82ydczid	247	20	treated	treat	VBN
cord-253295-82ydczid	247	21	differently	differently	RB
cord-253295-82ydczid	247	22	.	.	.
cord-253295-82ydczid	248	1	For	for	IN
cord-253295-82ydczid	248	2	example	example	NN
cord-253295-82ydczid	248	3	,	,	,
cord-253295-82ydczid	248	4	there	there	EX
cord-253295-82ydczid	248	5	is	be	VBZ
cord-253295-82ydczid	248	6	no	no	DT
cord-253295-82ydczid	248	7	morphologic	morphologic	JJ
cord-253295-82ydczid	248	8	evidence	evidence	NN
cord-253295-82ydczid	248	9	by	by	IN
cord-253295-82ydczid	248	10	H&E	H&E	NNP
cord-253295-82ydczid	248	11	stain	stain	VB
cord-253295-82ydczid	248	12	alone	alone	RB
cord-253295-82ydczid	248	13	to	to	TO
cord-253295-82ydczid	248	14	distinguish	distinguish	VB
cord-253295-82ydczid	248	15	host	host	NN
cord-253295-82ydczid	248	16	lymphoid	lymphoid	JJ
cord-253295-82ydczid	248	17	response	response	NN
cord-253295-82ydczid	248	18	to	to	IN
cord-253295-82ydczid	248	19	Hepatitis	Hepatitis	NNP
cord-253295-82ydczid	248	20	C	C	NNP
cord-253295-82ydczid	248	21	viral	viral	NN
cord-253295-82ydczid	248	22	(	(	-LRB-
cord-253295-82ydczid	248	23	HCV	HCV	NNP
cord-253295-82ydczid	248	24	)	)	-RRB-
cord-253295-82ydczid	248	25	antigens	antigen	NNS
cord-253295-82ydczid	248	26	from	from	IN
cord-253295-82ydczid	248	27	host	host	NN
cord-253295-82ydczid	248	28	lymphoid	lymphoid	JJ
cord-253295-82ydczid	248	29	response	response	NN
cord-253295-82ydczid	248	30	to	to	IN
cord-253295-82ydczid	248	31	allo	allo	NNP
cord-253295-82ydczid	248	32	-	-	HYPH
cord-253295-82ydczid	248	33	HLA	HLA	NNP
cord-253295-82ydczid	248	34	antigens	antigen	NNS
cord-253295-82ydczid	248	35	in	in	IN
cord-253295-82ydczid	248	36	a	a	DT
cord-253295-82ydczid	248	37	liver	liver	NN
cord-253295-82ydczid	248	38	allograft	allograft	NN
cord-253295-82ydczid	248	39	.	.	.
cord-253295-82ydczid	249	1	This	this	DT
cord-253295-82ydczid	249	2	is	be	VBZ
cord-253295-82ydczid	249	3	obviously	obviously	RB
cord-253295-82ydczid	249	4	a	a	DT
cord-253295-82ydczid	249	5	major	major	JJ
cord-253295-82ydczid	249	6	diagnostic	diagnostic	JJ
cord-253295-82ydczid	249	7	challenge	challenge	NN
cord-253295-82ydczid	249	8	when	when	WRB
cord-253295-82ydczid	249	9	the	the	DT
cord-253295-82ydczid	249	10	transplant	transplant	NN
cord-253295-82ydczid	249	11	was	be	VBD
cord-253295-82ydczid	249	12	done	do	VBN
cord-253295-82ydczid	249	13	for	for	IN
cord-253295-82ydczid	249	14	HCV	HCV	NNP
cord-253295-82ydczid	249	15	-	-	HYPH
cord-253295-82ydczid	249	16	related	relate	VBN
cord-253295-82ydczid	249	17	cirrhosis	cirrhosis	NN
cord-253295-82ydczid	249	18	,	,	,
cord-253295-82ydczid	249	19	and	and	CC
cord-253295-82ydczid	249	20	when	when	WRB
cord-253295-82ydczid	249	21	the	the	DT
cord-253295-82ydczid	249	22	probability	probability	NN
cord-253295-82ydczid	249	23	of	of	IN
cord-253295-82ydczid	249	24	recurrent	recurrent	JJ
cord-253295-82ydczid	249	25	HCV	HCV	NNP
cord-253295-82ydczid	249	26	infection	infection	NN
cord-253295-82ydczid	249	27	in	in	IN
cord-253295-82ydczid	249	28	the	the	DT
cord-253295-82ydczid	249	29	liver	liver	NN
cord-253295-82ydczid	249	30	allograft	allograft	NN
cord-253295-82ydczid	249	31	is	be	VBZ
cord-253295-82ydczid	249	32	high	high	JJ
cord-253295-82ydczid	249	33	.	.	.
cord-253295-82ydczid	250	1	Paraffin	paraffin	NN
cord-253295-82ydczid	250	2	section	section	NN
cord-253295-82ydczid	250	3	immunohistochemistry	immunohistochemistry	NN
cord-253295-82ydczid	250	4	has	have	VBZ
cord-253295-82ydczid	250	5	proven	prove	VBN
cord-253295-82ydczid	250	6	invaluable	invaluable	JJ
cord-253295-82ydczid	250	7	in	in	IN
cord-253295-82ydczid	250	8	neoplasm	neoplasm	JJ
cord-253295-82ydczid	250	9	diagnosis	diagnosis	NN
cord-253295-82ydczid	250	10	for	for	IN
cord-253295-82ydczid	250	11	clarifying	clarify	VBG
cord-253295-82ydczid	250	12	lineage	lineage	NN
cord-253295-82ydczid	250	13	,	,	,
cord-253295-82ydczid	250	14	improving	improve	VBG
cord-253295-82ydczid	250	15	diagnostic	diagnostic	JJ
cord-253295-82ydczid	250	16	accuracy	accuracy	NN
cord-253295-82ydczid	250	17	,	,	,
cord-253295-82ydczid	250	18	and	and	CC
cord-253295-82ydczid	250	19	guiding	guide	VBG
cord-253295-82ydczid	250	20	customized	customize	VBN
cord-253295-82ydczid	250	21	therapy	therapy	NN
cord-253295-82ydczid	250	22	.	.	.
cord-253295-82ydczid	251	1	If	if	IN
cord-253295-82ydczid	251	2	neoplasms	neoplasm	NNS
cord-253295-82ydczid	251	3	are	be	VBP
cord-253295-82ydczid	251	4	poorly	poorly	RB
cord-253295-82ydczid	251	5	differentiated	differentiate	VBN
cord-253295-82ydczid	251	6	or	or	CC
cord-253295-82ydczid	251	7	undifferentiated	undifferentiated	JJ
cord-253295-82ydczid	251	8	,	,	,
cord-253295-82ydczid	251	9	the	the	DT
cord-253295-82ydczid	251	10	lineage	lineage	NN
cord-253295-82ydczid	251	11	of	of	IN
cord-253295-82ydczid	251	12	the	the	DT
cord-253295-82ydczid	251	13	neoplasm	neoplasm	NN
cord-253295-82ydczid	251	14	may	may	MD
cord-253295-82ydczid	251	15	not	not	RB
cord-253295-82ydczid	251	16	be	be	VB
cord-253295-82ydczid	251	17	clear	clear	JJ
cord-253295-82ydczid	251	18	.	.	.
cord-253295-82ydczid	252	1	For	for	IN
cord-253295-82ydczid	252	2	example	example	NN
cord-253295-82ydczid	252	3	,	,	,
cord-253295-82ydczid	252	4	sheets	sheet	NNS
cord-253295-82ydczid	252	5	of	of	IN
cord-253295-82ydczid	252	6	undifferentiated	undifferentiated	JJ
cord-253295-82ydczid	252	7	malignant	malignant	JJ
cord-253295-82ydczid	252	8	neoplasm	neoplasm	NN
cord-253295-82ydczid	252	9	with	with	IN
cord-253295-82ydczid	252	10	prominent	prominent	JJ
cord-253295-82ydczid	252	11	nucleoli	nucleolus	NNS
cord-253295-82ydczid	252	12	could	could	MD
cord-253295-82ydczid	252	13	represent	represent	VB
cord-253295-82ydczid	252	14	carcinoma	carcinoma	NN
cord-253295-82ydczid	252	15	,	,	,
cord-253295-82ydczid	252	16	lymphoma	lymphoma	NN
cord-253295-82ydczid	252	17	,	,	,
cord-253295-82ydczid	252	18	or	or	CC
cord-253295-82ydczid	252	19	melanoma	melanoma	NN
cord-253295-82ydczid	252	20	.	.	.
cord-253295-82ydczid	253	1	To	to	TO
cord-253295-82ydczid	253	2	clarify	clarify	VB
cord-253295-82ydczid	253	3	lineage	lineage	NN
cord-253295-82ydczid	253	4	,	,	,
cord-253295-82ydczid	253	5	a	a	DT
cord-253295-82ydczid	253	6	panel	panel	NN
cord-253295-82ydczid	253	7	of	of	IN
cord-253295-82ydczid	253	8	immunostains	immunostains	NNP
cord-253295-82ydczid	253	9	is	be	VBZ
cord-253295-82ydczid	253	10	performed	perform	VBN
cord-253295-82ydczid	253	11	for	for	IN
cord-253295-82ydczid	253	12	proteins	protein	NNS
cord-253295-82ydczid	253	13	that	that	WDT
cord-253295-82ydczid	253	14	are	be	VBP
cord-253295-82ydczid	253	15	expressed	express	VBN
cord-253295-82ydczid	253	16	in	in	IN
cord-253295-82ydczid	253	17	some	some	DT
cord-253295-82ydczid	253	18	of	of	IN
cord-253295-82ydczid	253	19	the	the	DT
cord-253295-82ydczid	253	20	neoplasms	neoplasm	NNS
cord-253295-82ydczid	253	21	,	,	,
cord-253295-82ydczid	253	22	but	but	CC
cord-253295-82ydczid	253	23	not	not	RB
cord-253295-82ydczid	253	24	in	in	IN
cord-253295-82ydczid	253	25	others	other	NNS
cord-253295-82ydczid	253	26	.	.	.
cord-253295-82ydczid	254	1	Relative	relative	JJ
cord-253295-82ydczid	254	2	probabilities	probability	NNS
cord-253295-82ydczid	254	3	are	be	VBP
cord-253295-82ydczid	254	4	then	then	RB
cord-253295-82ydczid	254	5	used	use	VBN
cord-253295-82ydczid	254	6	to	to	TO
cord-253295-82ydczid	254	7	lend	lend	VB
cord-253295-82ydczid	254	8	support	support	NN
cord-253295-82ydczid	254	9	(	(	-LRB-
cord-253295-82ydczid	254	10	rule	rule	NN
cord-253295-82ydczid	254	11	in	in	IN
cord-253295-82ydczid	254	12	)	)	-RRB-
cord-253295-82ydczid	254	13	or	or	CC
cord-253295-82ydczid	254	14	exclude	exclude	VB
cord-253295-82ydczid	254	15	(	(	-LRB-
cord-253295-82ydczid	254	16	rule	rule	VB
cord-253295-82ydczid	254	17	out	out	RP
cord-253295-82ydczid	254	18	)	)	-RRB-
cord-253295-82ydczid	254	19	particular	particular	JJ
cord-253295-82ydczid	254	20	diagnoses	diagnosis	NNS
cord-253295-82ydczid	254	21	in	in	IN
cord-253295-82ydczid	254	22	the	the	DT
cord-253295-82ydczid	254	23	differential	differential	JJ
cord-253295-82ydczid	254	24	diagnosis	diagnosis	NN
cord-253295-82ydczid	254	25	of	of	IN
cord-253295-82ydczid	254	26	these	these	DT
cord-253295-82ydczid	254	27	several	several	JJ
cord-253295-82ydczid	254	28	morphologically	morphologically	RB
cord-253295-82ydczid	254	29	similar	similar	JJ
cord-253295-82ydczid	254	30	undifferentiated	undifferentiated	JJ
cord-253295-82ydczid	254	31	neoplasms	neoplasm	NNS
cord-253295-82ydczid	254	32	.	.	.
cord-253295-82ydczid	255	1	The	the	DT
cord-253295-82ydczid	255	2	second	second	JJ
cord-253295-82ydczid	255	3	role	role	NN
cord-253295-82ydczid	255	4	is	be	VBZ
cord-253295-82ydczid	255	5	to	to	TO
cord-253295-82ydczid	255	6	make	make	VB
cord-253295-82ydczid	255	7	critical	critical	JJ
cord-253295-82ydczid	255	8	distinctions	distinction	NNS
cord-253295-82ydczid	255	9	in	in	IN
cord-253295-82ydczid	255	10	diagnosis	diagnosis	NN
cord-253295-82ydczid	255	11	that	that	WDT
cord-253295-82ydczid	255	12	can	can	MD
cord-253295-82ydczid	255	13	not	not	RB
cord-253295-82ydczid	255	14	be	be	VB
cord-253295-82ydczid	255	15	accurately	accurately	RB
cord-253295-82ydczid	255	16	made	make	VBN
cord-253295-82ydczid	255	17	by	by	IN
cord-253295-82ydczid	255	18	H&E	H&E	NNP
cord-253295-82ydczid	255	19	alone	alone	JJ
cord-253295-82ydczid	255	20	.	.	.
cord-253295-82ydczid	256	1	Examples	example	NNS
cord-253295-82ydczid	256	2	of	of	IN
cord-253295-82ydczid	256	3	this	this	DT
cord-253295-82ydczid	256	4	would	would	MD
cord-253295-82ydczid	256	5	include	include	VB
cord-253295-82ydczid	256	6	demonstration	demonstration	NN
cord-253295-82ydczid	256	7	of	of	IN
cord-253295-82ydczid	256	8	myoepithelial	myoepithelial	JJ
cord-253295-82ydczid	256	9	cell	cell	NN
cord-253295-82ydczid	256	10	loss	loss	NN
cord-253295-82ydczid	256	11	in	in	IN
cord-253295-82ydczid	256	12	invasive	invasive	JJ
cord-253295-82ydczid	256	13	breast	breast	NN
cord-253295-82ydczid	256	14	carcinoma	carcinoma	NN
cord-253295-82ydczid	256	15	but	but	CC
cord-253295-82ydczid	256	16	not	not	RB
cord-253295-82ydczid	256	17	in	in	IN
cord-253295-82ydczid	256	18	its	-PRON-	PRP$
cord-253295-82ydczid	256	19	mimic	mimic	JJ
cord-253295-82ydczid	256	20	,	,	,
cord-253295-82ydczid	256	21	sclerosing	sclerose	VBG
cord-253295-82ydczid	256	22	adenosis	adenosis	NN
cord-253295-82ydczid	256	23	(	(	-LRB-
cord-253295-82ydczid	256	24	Fig	Fig	NNP
cord-253295-82ydczid	256	25	.	.	.
cord-253295-82ydczid	256	26	11.2	11.2	CD
cord-253295-82ydczid	256	27	prostatic	prostatic	JJ
cord-253295-82ydczid	256	28	adenocarcinoma	adenocarcinoma	NN
cord-253295-82ydczid	256	29	(	(	-LRB-
cord-253295-82ydczid	256	30	Fig	fig	NN
cord-253295-82ydczid	256	31	.	.	.
cord-253295-82ydczid	256	32	11.3	11.3	CD
cord-253295-82ydczid	256	33	)	)	-RRB-
cord-253295-82ydczid	256	34	.	.	.
cord-253295-82ydczid	257	1	The	the	DT
cord-253295-82ydczid	257	2	third	third	JJ
cord-253295-82ydczid	257	3	role	role	NN
cord-253295-82ydczid	257	4	of	of	IN
cord-253295-82ydczid	257	5	immunohistochemistry	immunohistochemistry	NN
cord-253295-82ydczid	257	6	is	be	VBZ
cord-253295-82ydczid	257	7	to	to	TO
cord-253295-82ydczid	257	8	identify	identify	VB
cord-253295-82ydczid	257	9	particular	particular	JJ
cord-253295-82ydczid	257	10	proteins	protein	NNS
cord-253295-82ydczid	257	11	,	,	,
cord-253295-82ydczid	257	12	such	such	JJ
cord-253295-82ydczid	257	13	as	as	IN
cord-253295-82ydczid	257	14	nuclear	nuclear	JJ
cord-253295-82ydczid	257	15	estrogen	estrogen	NN
cord-253295-82ydczid	257	16	receptor	receptor	NN
cord-253295-82ydczid	257	17	(	(	-LRB-
cord-253295-82ydczid	257	18	ER	ER	NNP
cord-253295-82ydczid	257	19	)	)	-RRB-
cord-253295-82ydczid	257	20	(	(	-LRB-
cord-253295-82ydczid	257	21	Fig	Fig	NNP
cord-253295-82ydczid	257	22	.	.	.
cord-253295-82ydczid	257	23	11.4	11.4	CD
cord-253295-82ydczid	257	24	)	)	-RRB-
cord-253295-82ydczid	257	25	or	or	CC
cord-253295-82ydczid	257	26	the	the	DT
cord-253295-82ydczid	257	27	plasma	plasma	NN
cord-253295-82ydczid	257	28	membrane	membrane	NN
cord-253295-82ydczid	257	29	HER2	HER2	NNP
cord-253295-82ydczid	257	30	proteins	protein	NNS
cord-253295-82ydczid	257	31	(	(	-LRB-
cord-253295-82ydczid	257	32	Fig	Fig	NNP
cord-253295-82ydczid	257	33	.	.	.
cord-253295-82ydczid	257	34	11	11	CD
cord-253295-82ydczid	257	35	.5	.5	CD
cord-253295-82ydczid	257	36	)	)	-RRB-
cord-253295-82ydczid	257	37	,	,	,
cord-253295-82ydczid	257	38	both	both	DT
cord-253295-82ydczid	257	39	of	of	IN
cord-253295-82ydczid	257	40	which	which	WDT
cord-253295-82ydczid	257	41	can	can	MD
cord-253295-82ydczid	257	42	be	be	VB
cord-253295-82ydczid	257	43	targeted	target	VBN
cord-253295-82ydczid	257	44	with	with	IN
cord-253295-82ydczid	257	45	inhibitors	inhibitor	NNS
cord-253295-82ydczid	257	46	rather	rather	RB
cord-253295-82ydczid	257	47	than	than	IN
cord-253295-82ydczid	257	48	generalized	generalize	VBN
cord-253295-82ydczid	257	49	systemic	systemic	JJ
cord-253295-82ydczid	257	50	chemotherapy	chemotherapy	NN
cord-253295-82ydczid	257	51	.	.	.
cord-253295-82ydczid	258	1	Morphology	morphology	NN
cord-253295-82ydczid	258	2	remains	remain	VBZ
cord-253295-82ydczid	258	3	the	the	DT
cord-253295-82ydczid	258	4	gold	gold	NN
cord-253295-82ydczid	258	5	standard	standard	NN
cord-253295-82ydczid	258	6	in	in	IN
cord-253295-82ydczid	258	7	this	this	DT
cord-253295-82ydczid	258	8	diagnostic	diagnostic	JJ
cord-253295-82ydczid	258	9	process	process	NN
cord-253295-82ydczid	258	10	,	,	,
cord-253295-82ydczid	258	11	such	such	JJ
cord-253295-82ydczid	258	12	that	that	IN
cord-253295-82ydczid	258	13	immunohistochemical	immunohistochemical	JJ
cord-253295-82ydczid	258	14	data	data	NN
cord-253295-82ydczid	258	15	support	support	NN
cord-253295-82ydczid	258	16	or	or	CC
cord-253295-82ydczid	258	17	fail	fail	VBP
cord-253295-82ydczid	258	18	to	to	TO
cord-253295-82ydczid	258	19	support	support	VB
cord-253295-82ydczid	258	20	the	the	DT
cord-253295-82ydczid	258	21	H&E	H&E	NNP
cord-253295-82ydczid	258	22	findings	finding	NNS
cord-253295-82ydczid	258	23	,	,	,
cord-253295-82ydczid	258	24	not	not	RB
cord-253295-82ydczid	258	25	vice	vice	RB
cord-253295-82ydczid	258	26	versa	versa	RB
cord-253295-82ydczid	258	27	.	.	.
cord-253295-82ydczid	259	1	Probability	probability	NN
cord-253295-82ydczid	259	2	and	and	CC
cord-253295-82ydczid	259	3	statistics	statistic	NNS
cord-253295-82ydczid	259	4	are	be	VBP
cord-253295-82ydczid	259	5	regular	regular	JJ
cord-253295-82ydczid	259	6	considerations	consideration	NNS
cord-253295-82ydczid	259	7	in	in	IN
cord-253295-82ydczid	259	8	immunohistochemical	immunohistochemical	JJ
cord-253295-82ydczid	259	9	interpretation	interpretation	NN
cord-253295-82ydczid	259	10	,	,	,
cord-253295-82ydczid	259	11	since	since	IN
cord-253295-82ydczid	259	12	very	very	RB
cord-253295-82ydczid	259	13	few	few	JJ
cord-253295-82ydczid	259	14	antigens	antigen	NNS
cord-253295-82ydczid	259	15	are	be	VBP
cord-253295-82ydczid	259	16	tissue	tissue	NN
cord-253295-82ydczid	259	17	-	-	HYPH
cord-253295-82ydczid	259	18	specific	specific	JJ
cord-253295-82ydczid	259	19	or	or	CC
cord-253295-82ydczid	259	20	lineage	lineage	NN
cord-253295-82ydczid	259	21	-	-	HYPH
cord-253295-82ydczid	259	22	specific	specific	JJ
cord-253295-82ydczid	259	23	.	.	.
cord-253295-82ydczid	260	1	Cytokeratin	Cytokeratin	NNP
cord-253295-82ydczid	260	2	is	be	VBZ
cord-253295-82ydczid	260	3	positive	positive	JJ
cord-253295-82ydczid	260	4	in	in	IN
cord-253295-82ydczid	260	5	carcinomas	carcinoma	NNS
cord-253295-82ydczid	260	6	,	,	,
cord-253295-82ydczid	260	7	but	but	CC
cord-253295-82ydczid	260	8	also	also	RB
cord-253295-82ydczid	260	9	in	in	IN
cord-253295-82ydczid	260	10	synovial	synovial	JJ
cord-253295-82ydczid	260	11	and	and	CC
cord-253295-82ydczid	260	12	epithelioid	epithelioid	JJ
cord-253295-82ydczid	260	13	sarcomas	sarcoma	NNS
cord-253295-82ydczid	260	14	.	.	.
cord-253295-82ydczid	261	1	This	this	DT
cord-253295-82ydczid	261	2	example	example	NN
cord-253295-82ydczid	261	3	may	may	MD
cord-253295-82ydczid	261	4	imply	imply	VB
cord-253295-82ydczid	261	5	aspects	aspect	NNS
cord-253295-82ydczid	261	6	of	of	IN
cord-253295-82ydczid	261	7	the	the	DT
cord-253295-82ydczid	261	8	lineage	lineage	NN
cord-253295-82ydczid	261	9	of	of	IN
cord-253295-82ydczid	261	10	these	these	DT
cord-253295-82ydczid	261	11	two	two	CD
cord-253295-82ydczid	261	12	sarcomas	sarcoma	NNS
cord-253295-82ydczid	261	13	that	that	WDT
cord-253295-82ydczid	261	14	may	may	MD
cord-253295-82ydczid	261	15	be	be	VB
cord-253295-82ydczid	261	16	helpful	helpful	JJ
cord-253295-82ydczid	261	17	in	in	IN
cord-253295-82ydczid	261	18	our	-PRON-	PRP$
cord-253295-82ydczid	261	19	categorization	categorization	NN
cord-253295-82ydczid	261	20	of	of	IN
cord-253295-82ydczid	261	21	these	these	DT
cord-253295-82ydczid	261	22	neoplasms	neoplasm	NNS
cord-253295-82ydczid	261	23	.	.	.
cord-253295-82ydczid	262	1	Another	another	DT
cord-253295-82ydczid	262	2	example	example	NN
cord-253295-82ydczid	262	3	would	would	MD
cord-253295-82ydczid	262	4	be	be	VB
cord-253295-82ydczid	262	5	the	the	DT
cord-253295-82ydczid	262	6	diagnosis	diagnosis	NN
cord-253295-82ydczid	262	7	of	of	IN
cord-253295-82ydczid	262	8	small	small	JJ
cord-253295-82ydczid	262	9	cell	cell	NN
cord-253295-82ydczid	262	10	carcinoma	carcinoma	NN
cord-253295-82ydczid	262	11	in	in	IN
cord-253295-82ydczid	262	12	the	the	DT
cord-253295-82ydczid	262	13	lung	lung	NN
cord-253295-82ydczid	262	14	of	of	IN
cord-253295-82ydczid	262	15	a	a	DT
cord-253295-82ydczid	262	16	nonsmoker	nonsmoker	NN
cord-253295-82ydczid	262	17	.	.	.
cord-253295-82ydczid	263	1	Because	because	IN
cord-253295-82ydczid	263	2	lung	lung	NN
cord-253295-82ydczid	263	3	primary	primary	JJ
cord-253295-82ydczid	263	4	small	small	JJ
cord-253295-82ydczid	263	5	cell	cell	NN
cord-253295-82ydczid	263	6	carcinoma	carcinoma	NN
cord-253295-82ydczid	263	7	is	be	VBZ
cord-253295-82ydczid	263	8	extremely	extremely	RB
cord-253295-82ydczid	263	9	uncommon	uncommon	JJ
cord-253295-82ydczid	263	10	,	,	,
cord-253295-82ydczid	263	11	in	in	IN
cord-253295-82ydczid	263	12	non	non	NNS
cord-253295-82ydczid	263	13	-	-	NNS
cord-253295-82ydczid	263	14	smokers	smoker	NNS
cord-253295-82ydczid	263	15	,	,	,
cord-253295-82ydczid	263	16	this	this	DT
cord-253295-82ydczid	263	17	diagnosis	diagnosis	NN
cord-253295-82ydczid	263	18	would	would	MD
cord-253295-82ydczid	263	19	prompt	prompt	VB
cord-253295-82ydczid	263	20	the	the	DT
cord-253295-82ydczid	263	21	pathologist	pathologist	NN
cord-253295-82ydczid	263	22	to	to	TO
cord-253295-82ydczid	263	23	inquire	inquire	VB
cord-253295-82ydczid	263	24	about	about	IN
cord-253295-82ydczid	263	25	screening	screening	NN
cord-253295-82ydczid	263	26	results	result	NNS
cord-253295-82ydczid	263	27	for	for	IN
cord-253295-82ydczid	263	28	other	other	JJ
cord-253295-82ydczid	263	29	,	,	,
cord-253295-82ydczid	263	30	non	non	JJ
cord-253295-82ydczid	263	31	-	-	JJ
cord-253295-82ydczid	263	32	pulmonary	pulmonary	JJ
cord-253295-82ydczid	263	33	,	,	,
cord-253295-82ydczid	263	34	sites	site	NNS
cord-253295-82ydczid	263	35	.	.	.
cord-253295-82ydczid	264	1	Likewise	likewise	RB
cord-253295-82ydczid	264	2	,	,	,
cord-253295-82ydczid	264	3	immunohistochemistry	immunohistochemistry	NN
cord-253295-82ydczid	264	4	results	result	NNS
cord-253295-82ydczid	264	5	are	be	VBP
cord-253295-82ydczid	264	6	always	always	RB
cord-253295-82ydczid	264	7	put	put	VBN
cord-253295-82ydczid	264	8	into	into	IN
cord-253295-82ydczid	264	9	the	the	DT
cord-253295-82ydczid	264	10	context	context	NN
cord-253295-82ydczid	264	11	of	of	IN
cord-253295-82ydczid	264	12	the	the	DT
cord-253295-82ydczid	264	13	morphologic	morphologic	JJ
cord-253295-82ydczid	264	14	,	,	,
cord-253295-82ydczid	264	15	clinical	clinical	JJ
cord-253295-82ydczid	264	16	,	,	,
cord-253295-82ydczid	264	17	and	and	CC
cord-253295-82ydczid	264	18	radiographic	radiographic	JJ
cord-253295-82ydczid	264	19	findings	finding	NNS
cord-253295-82ydczid	264	20	.	.	.
cord-253295-82ydczid	265	1	For	for	IN
cord-253295-82ydczid	265	2	example	example	NN
cord-253295-82ydczid	265	3	,	,	,
cord-253295-82ydczid	265	4	an	an	DT
cord-253295-82ydczid	265	5	undifferentiated	undifferentiated	JJ
cord-253295-82ydczid	265	6	CD30	CD30	NNP
cord-253295-82ydczid	265	7	+	+	CC
cord-253295-82ydczid	265	8	neoplasm	neoplasm	NN
cord-253295-82ydczid	265	9	of	of	IN
cord-253295-82ydczid	265	10	the	the	DT
cord-253295-82ydczid	265	11	testis	testis	NN
cord-253295-82ydczid	265	12	supports	support	VBZ
cord-253295-82ydczid	265	13	embryonal	embryonal	JJ
cord-253295-82ydczid	265	14	carcinoma	carcinoma	NN
cord-253295-82ydczid	265	15	primary	primary	NN
cord-253295-82ydczid	265	16	in	in	IN
cord-253295-82ydczid	265	17	the	the	DT
cord-253295-82ydczid	265	18	testis	testis	NN
cord-253295-82ydczid	265	19	,	,	,
cord-253295-82ydczid	265	20	whereas	whereas	IN
cord-253295-82ydczid	265	21	a	a	DT
cord-253295-82ydczid	265	22	lymph	lymph	NN
cord-253295-82ydczid	265	23	node	node	NN
cord-253295-82ydczid	265	24	effaced	efface	VBN
cord-253295-82ydczid	265	25	by	by	IN
cord-253295-82ydczid	265	26	sclerotic	sclerotic	JJ
cord-253295-82ydczid	265	27	bands	band	NNS
cord-253295-82ydczid	265	28	with	with	IN
cord-253295-82ydczid	265	29	admixed	admix	VBN
cord-253295-82ydczid	265	30	CD30	CD30	NNP
cord-253295-82ydczid	265	31	+	+	CC
cord-253295-82ydczid	265	32	Reed	Reed	NNP
cord-253295-82ydczid	265	33	-	-	HYPH
cord-253295-82ydczid	265	34	Sternberg	Sternberg	NNP
cord-253295-82ydczid	265	35	cells	cell	NNS
cord-253295-82ydczid	265	36	supports	support	VBZ
cord-253295-82ydczid	265	37	nodular	nodular	JJ
cord-253295-82ydczid	265	38	sclerosing	sclerose	VBG
cord-253295-82ydczid	265	39	Hodgkin	Hodgkin	NNP
cord-253295-82ydczid	265	40	's	's	POS
cord-253295-82ydczid	265	41	disease	disease	NN
cord-253295-82ydczid	265	42	.	.	.
cord-253295-82ydczid	266	1	Demand	demand	NN
cord-253295-82ydczid	266	2	for	for	IN
cord-253295-82ydczid	266	3	both	both	CC
cord-253295-82ydczid	266	4	diagnostic	diagnostic	JJ
cord-253295-82ydczid	266	5	accuracy	accuracy	NN
cord-253295-82ydczid	266	6	and	and	CC
cord-253295-82ydczid	266	7	report	report	NN
cord-253295-82ydczid	266	8	promptness	promptness	NN
cord-253295-82ydczid	266	9	has	have	VBZ
cord-253295-82ydczid	266	10	increased	increase	VBN
cord-253295-82ydczid	266	11	as	as	IN
cord-253295-82ydczid	266	12	hospitals	hospital	NNS
cord-253295-82ydczid	266	13	come	come	VBP
cord-253295-82ydczid	266	14	under	under	IN
cord-253295-82ydczid	266	15	increasing	increase	VBG
cord-253295-82ydczid	266	16	financial	financial	JJ
cord-253295-82ydczid	266	17	pressure	pressure	NN
cord-253295-82ydczid	266	18	to	to	TO
cord-253295-82ydczid	266	19	minimize	minimize	VB
cord-253295-82ydczid	266	20	length	length	NN
cord-253295-82ydczid	266	21	of	of	IN
cord-253295-82ydczid	266	22	patient	patient	NN
cord-253295-82ydczid	266	23	stay	stay	NN
cord-253295-82ydczid	266	24	.	.	.
cord-253295-82ydczid	267	1	Hospitals	hospital	NNS
cord-253295-82ydczid	267	2	now	now	RB
cord-253295-82ydczid	267	3	manage	manage	VBP
cord-253295-82ydczid	267	4	all	all	DT
cord-253295-82ydczid	267	5	but	but	IN
cord-253295-82ydczid	267	6	the	the	DT
cord-253295-82ydczid	267	7	sickest	sick	JJS
cord-253295-82ydczid	267	8	patients	patient	NNS
cord-253295-82ydczid	267	9	as	as	IN
cord-253295-82ydczid	267	10	outpatients	outpatient	NNS
cord-253295-82ydczid	267	11	.	.	.
cord-253295-82ydczid	268	1	Minimally	minimally	RB
cord-253295-82ydczid	268	2	invasive	invasive	JJ
cord-253295-82ydczid	268	3	approaches	approach	NNS
cord-253295-82ydczid	268	4	for	for	IN
cord-253295-82ydczid	268	5	the	the	DT
cord-253295-82ydczid	268	6	acquisition	acquisition	NN
cord-253295-82ydczid	268	7	of	of	IN
cord-253295-82ydczid	268	8	tissue	tissue	NN
cord-253295-82ydczid	268	9	samples	sample	NNS
cord-253295-82ydczid	268	10	for	for	IN
cord-253295-82ydczid	268	11	diagnosis	diagnosis	NN
cord-253295-82ydczid	268	12	use	use	VBP
cord-253295-82ydczid	268	13	flexible	flexible	JJ
cord-253295-82ydczid	268	14	endoscopic	endoscopic	NNS
cord-253295-82ydczid	268	15	biotomes	biotome	NNS
cord-253295-82ydczid	268	16	or	or	CC
cord-253295-82ydczid	268	17	hollow	hollow	JJ
cord-253295-82ydczid	268	18	needles	needle	NNS
cord-253295-82ydczid	268	19	that	that	WDT
cord-253295-82ydczid	268	20	sample	sample	VBP
cord-253295-82ydczid	268	21	1À2	1à2	CD
cord-253295-82ydczid	268	22	mm	mm	NN
cord-253295-82ydczid	268	23	diameter	diameter	NN
cord-253295-82ydczid	268	24	tissue	tissue	NN
cord-253295-82ydczid	268	25	specimens	specimen	NNS
cord-253295-82ydczid	268	26	.	.	.
cord-253295-82ydczid	269	1	Multidisciplinary	multidisciplinary	JJ
cord-253295-82ydczid	269	2	conferences	conference	NNS
cord-253295-82ydczid	269	3	function	function	VBP
cord-253295-82ydczid	269	4	almost	almost	RB
cord-253295-82ydczid	269	5	realtime	realtime	RB
cord-253295-82ydczid	269	6	with	with	IN
cord-253295-82ydczid	269	7	respect	respect	NN
cord-253295-82ydczid	269	8	to	to	IN
cord-253295-82ydczid	269	9	the	the	DT
cord-253295-82ydczid	269	10	initial	initial	JJ
cord-253295-82ydczid	269	11	biopsies	biopsy	NNS
cord-253295-82ydczid	269	12	.	.	.
cord-253295-82ydczid	270	1	Together	together	RB
cord-253295-82ydczid	270	2	,	,	,
cord-253295-82ydczid	270	3	these	these	DT
cord-253295-82ydczid	270	4	changes	change	NNS
cord-253295-82ydczid	270	5	have	have	VBP
cord-253295-82ydczid	270	6	forced	force	VBN
cord-253295-82ydczid	270	7	modern	modern	JJ
cord-253295-82ydczid	270	8	pathologists	pathologist	NNS
cord-253295-82ydczid	270	9	to	to	TO
cord-253295-82ydczid	270	10	make	make	VB
cord-253295-82ydczid	270	11	critical	critical	JJ
cord-253295-82ydczid	270	12	diagnoses	diagnosis	NNS
cord-253295-82ydczid	270	13	on	on	IN
cord-253295-82ydczid	270	14	progressively	progressively	RB
cord-253295-82ydczid	270	15	smaller	small	JJR
cord-253295-82ydczid	270	16	biopsy	biopsy	NN
cord-253295-82ydczid	270	17	specimens	specimen	NNS
cord-253295-82ydczid	270	18	,	,	,
cord-253295-82ydczid	270	19	sometimes	sometimes	RB
cord-253295-82ydczid	270	20	bordering	border	VBG
cord-253295-82ydczid	270	21	on	on	IN
cord-253295-82ydczid	270	22	the	the	DT
cord-253295-82ydczid	270	23	amounts	amount	NNS
cord-253295-82ydczid	270	24	seen	see	VBN
cord-253295-82ydczid	270	25	in	in	IN
cord-253295-82ydczid	270	26	cytopathology	cytopathology	NN
cord-253295-82ydczid	270	27	aspirates	aspirate	NNS
cord-253295-82ydczid	270	28	,	,	,
cord-253295-82ydczid	270	29	and	and	CC
cord-253295-82ydczid	270	30	to	to	TO
cord-253295-82ydczid	270	31	do	do	VB
cord-253295-82ydczid	270	32	this	this	DT
cord-253295-82ydczid	270	33	in	in	IN
cord-253295-82ydczid	270	34	a	a	DT
cord-253295-82ydczid	270	35	timely	timely	JJ
cord-253295-82ydczid	270	36	fashion	fashion	NN
cord-253295-82ydczid	270	37	.	.	.
cord-253295-82ydczid	271	1	This	this	DT
cord-253295-82ydczid	271	2	requires	require	VBZ
cord-253295-82ydczid	271	3	a	a	DT
cord-253295-82ydczid	271	4	clear	clear	JJ
cord-253295-82ydczid	271	5	understanding	understanding	NN
cord-253295-82ydczid	271	6	of	of	IN
cord-253295-82ydczid	271	7	the	the	DT
cord-253295-82ydczid	271	8	limitations	limitation	NNS
cord-253295-82ydczid	271	9	to	to	IN
cord-253295-82ydczid	271	10	development	development	NN
cord-253295-82ydczid	271	11	of	of	IN
cord-253295-82ydczid	271	12	an	an	DT
cord-253295-82ydczid	271	13	accurate	accurate	JJ
cord-253295-82ydczid	271	14	diagnosis	diagnosis	NN
cord-253295-82ydczid	271	15	,	,	,
cord-253295-82ydczid	271	16	and	and	CC
cord-253295-82ydczid	271	17	a	a	DT
cord-253295-82ydczid	271	18	willingness	willingness	NN
cord-253295-82ydczid	271	19	on	on	IN
cord-253295-82ydczid	271	20	the	the	DT
cord-253295-82ydczid	271	21	part	part	NN
cord-253295-82ydczid	271	22	of	of	IN
cord-253295-82ydczid	271	23	the	the	DT
cord-253295-82ydczid	271	24	pathologist	pathologist	NN
cord-253295-82ydczid	271	25	to	to	TO
cord-253295-82ydczid	271	26	request	request	VB
cord-253295-82ydczid	271	27	repeat	repeat	NN
cord-253295-82ydczid	271	28	biopsy	biopsy	JJ
cord-253295-82ydczid	271	29	for	for	IN
cord-253295-82ydczid	271	30	additional	additional	JJ
cord-253295-82ydczid	271	31	tissue	tissue	NN
cord-253295-82ydczid	271	32	when	when	WRB
cord-253295-82ydczid	271	33	it	-PRON-	PRP
cord-253295-82ydczid	271	34	is	be	VBZ
cord-253295-82ydczid	271	35	necessary	necessary	JJ
cord-253295-82ydczid	271	36	for	for	IN
cord-253295-82ydczid	271	37	accurate	accurate	JJ
cord-253295-82ydczid	271	38	diagnosis	diagnosis	NN
cord-253295-82ydczid	271	39	.	.	.
cord-253295-82ydczid	272	1	Diagnostic	diagnostic	JJ
cord-253295-82ydczid	272	2	criteria	criterion	NNS
cord-253295-82ydczid	272	3	involving	involve	VBG
cord-253295-82ydczid	272	4	electron	electron	NN
cord-253295-82ydczid	272	5	microscopic	microscopic	JJ
cord-253295-82ydczid	272	6	ultrastructure	ultrastructure	NN
cord-253295-82ydczid	272	7	found	find	VBD
cord-253295-82ydczid	272	8	relevance	relevance	NN
cord-253295-82ydczid	272	9	for	for	IN
cord-253295-82ydczid	272	10	the	the	DT
cord-253295-82ydczid	272	11	evaluation	evaluation	NN
cord-253295-82ydczid	272	12	of	of	IN
cord-253295-82ydczid	272	13	neoplasms	neoplasm	NNS
cord-253295-82ydczid	272	14	described	describe	VBN
cord-253295-82ydczid	272	15	as	as	IN
cord-253295-82ydczid	272	16	small	small	JJ
cord-253295-82ydczid	272	17	round	round	JJ
cord-253295-82ydczid	272	18	blue	blue	JJ
cord-253295-82ydczid	272	19	cell	cell	NN
cord-253295-82ydczid	272	20	tumors	tumor	NNS
cord-253295-82ydczid	272	21	,	,	,
cord-253295-82ydczid	272	22	spindle	spindle	NN
cord-253295-82ydczid	272	23	cell	cell	NN
cord-253295-82ydczid	272	24	tumors	tumor	NNS
cord-253295-82ydczid	272	25	,	,	,
cord-253295-82ydczid	272	26	melanocytic	melanocytic	JJ
cord-253295-82ydczid	272	27	tumors	tumor	NNS
cord-253295-82ydczid	272	28	,	,	,
cord-253295-82ydczid	272	29	and	and	CC
cord-253295-82ydczid	272	30	neuroendocrine	neuroendocrine	JJ
cord-253295-82ydczid	272	31	/	/	SYM
cord-253295-82ydczid	272	32	neuroblastic	neuroblastic	JJ
cord-253295-82ydczid	272	33	tumors	tumor	NNS
cord-253295-82ydczid	272	34	,	,	,
cord-253295-82ydczid	272	35	as	as	RB
cord-253295-82ydczid	272	36	well	well	RB
cord-253295-82ydczid	272	37	as	as	IN
cord-253295-82ydczid	272	38	delineation	delineation	NN
cord-253295-82ydczid	272	39	of	of	IN
cord-253295-82ydczid	272	40	ciliary	ciliary	JJ
cord-253295-82ydczid	272	41	ultrastructural	ultrastructural	JJ
cord-253295-82ydczid	272	42	abnormalities	abnormality	NNS
cord-253295-82ydczid	272	43	in	in	IN
cord-253295-82ydczid	272	44	primary	primary	JJ
cord-253295-82ydczid	272	45	ciliary	ciliary	NN
cord-253295-82ydczid	272	46	dyskinesia	dyskinesia	NN
cord-253295-82ydczid	272	47	.	.	.
cord-253295-82ydczid	273	1	Current	current	JJ
cord-253295-82ydczid	273	2	approaches	approach	NNS
cord-253295-82ydczid	273	3	to	to	IN
cord-253295-82ydczid	273	4	these	these	DT
cord-253295-82ydczid	273	5	neoplasms	neoplasm	NNS
cord-253295-82ydczid	273	6	are	be	VBP
cord-253295-82ydczid	273	7	now	now	RB
cord-253295-82ydczid	273	8	generally	generally	RB
cord-253295-82ydczid	273	9	approached	approach	VBN
cord-253295-82ydczid	273	10	using	use	VBG
cord-253295-82ydczid	273	11	paraffin	paraffin	NN
cord-253295-82ydczid	273	12	section	section	NN
cord-253295-82ydczid	273	13	immunohistochemistry	immunohistochemistry	NN
cord-253295-82ydczid	273	14	.	.	.
cord-253295-82ydczid	274	1	Electron	electron	NN
cord-253295-82ydczid	274	2	microscopy	microscopy	NN
cord-253295-82ydczid	274	3	is	be	VBZ
cord-253295-82ydczid	274	4	now	now	RB
cord-253295-82ydczid	274	5	currently	currently	RB
cord-253295-82ydczid	274	6	used	use	VBN
cord-253295-82ydczid	274	7	mainly	mainly	RB
cord-253295-82ydczid	274	8	for	for	IN
cord-253295-82ydczid	274	9	nephropathology	nephropathology	NN
cord-253295-82ydczid	274	10	,	,	,
cord-253295-82ydczid	274	11	platelet	platelet	NN
cord-253295-82ydczid	274	12	morphology	morphology	NN
cord-253295-82ydczid	274	13	,	,	,
cord-253295-82ydczid	274	14	ciliary	ciliary	NN
cord-253295-82ydczid	274	15	axoneme	axoneme	NN
cord-253295-82ydczid	274	16	morphology	morphology	NN
cord-253295-82ydczid	274	17	,	,	,
cord-253295-82ydczid	274	18	and	and	CC
cord-253295-82ydczid	274	19	for	for	IN
cord-253295-82ydczid	274	20	rare	rare	JJ
cord-253295-82ydczid	274	21	cases	case	NNS
cord-253295-82ydczid	274	22	where	where	WRB
cord-253295-82ydczid	274	23	immunohistochemistry	immunohistochemistry	NN
cord-253295-82ydczid	274	24	is	be	VBZ
cord-253295-82ydczid	274	25	not	not	RB
cord-253295-82ydczid	274	26	diagnostic	diagnostic	JJ
cord-253295-82ydczid	274	27	and	and	CC
cord-253295-82ydczid	274	28	where	where	WRB
cord-253295-82ydczid	274	29	demonstration	demonstration	NN
cord-253295-82ydczid	274	30	of	of	IN
cord-253295-82ydczid	274	31	premelanosomes	premelanosome	NNS
cord-253295-82ydczid	274	32	,	,	,
cord-253295-82ydczid	274	33	neuroendocrine	neuroendocrine	JJ
cord-253295-82ydczid	274	34	granules	granule	NNS
cord-253295-82ydczid	274	35	,	,	,
cord-253295-82ydczid	274	36	or	or	CC
cord-253295-82ydczid	274	37	amyloid	amyloid	NN
cord-253295-82ydczid	274	38	is	be	VBZ
cord-253295-82ydczid	274	39	diagnostic	diagnostic	JJ
cord-253295-82ydczid	274	40	.	.	.
cord-253295-82ydczid	275	1	Adequate	adequate	JJ
cord-253295-82ydczid	275	2	sampling	sampling	NN
cord-253295-82ydczid	275	3	of	of	IN
cord-253295-82ydczid	275	4	a	a	DT
cord-253295-82ydczid	275	5	lesion	lesion	NN
cord-253295-82ydczid	275	6	is	be	VBZ
cord-253295-82ydczid	275	7	critical	critical	JJ
cord-253295-82ydczid	275	8	to	to	IN
cord-253295-82ydczid	275	9	making	make	VBG
cord-253295-82ydczid	275	10	an	an	DT
cord-253295-82ydczid	275	11	accurate	accurate	JJ
cord-253295-82ydczid	275	12	diagnosis	diagnosis	NN
cord-253295-82ydczid	275	13	.	.	.
cord-253295-82ydczid	276	1	Undercall	Undercall	NNP
cord-253295-82ydczid	276	2	diagnostic	diagnostic	JJ
cord-253295-82ydczid	276	3	discrepancies	discrepancy	NNS
cord-253295-82ydczid	276	4	are	be	VBP
cord-253295-82ydczid	276	5	frequently	frequently	RB
cord-253295-82ydczid	276	6	due	due	JJ
cord-253295-82ydczid	276	7	to	to	IN
cord-253295-82ydczid	276	8	sampling	sampling	NN
cord-253295-82ydczid	276	9	of	of	IN
cord-253295-82ydczid	276	10	a	a	DT
cord-253295-82ydczid	276	11	small	small	JJ
cord-253295-82ydczid	276	12	portion	portion	NN
cord-253295-82ydczid	276	13	of	of	IN
cord-253295-82ydczid	276	14	a	a	DT
cord-253295-82ydczid	276	15	large	large	JJ
cord-253295-82ydczid	276	16	lesion	lesion	NN
cord-253295-82ydczid	276	17	that	that	WDT
cord-253295-82ydczid	276	18	is	be	VBZ
cord-253295-82ydczid	276	19	not	not	RB
cord-253295-82ydczid	276	20	representative	representative	JJ
cord-253295-82ydczid	276	21	of	of	IN
cord-253295-82ydczid	276	22	the	the	DT
cord-253295-82ydczid	276	23	most	most	RBS
cord-253295-82ydczid	276	24	abnormal	abnormal	JJ
cord-253295-82ydczid	276	25	portion	portion	NN
cord-253295-82ydczid	276	26	of	of	IN
cord-253295-82ydczid	276	27	the	the	DT
cord-253295-82ydczid	276	28	lesion	lesion	NN
cord-253295-82ydczid	276	29	.	.	.
cord-253295-82ydczid	277	1	Insufficient	insufficient	JJ
cord-253295-82ydczid	277	2	sampling	sampling	NN
cord-253295-82ydczid	277	3	can	can	MD
cord-253295-82ydczid	277	4	result	result	VB
cord-253295-82ydczid	277	5	in	in	IN
cord-253295-82ydczid	277	6	an	an	DT
cord-253295-82ydczid	277	7	equivocal	equivocal	JJ
cord-253295-82ydczid	277	8	diagnosis	diagnosis	NN
cord-253295-82ydczid	277	9	or	or	CC
cord-253295-82ydczid	277	10	,	,	,
cord-253295-82ydczid	277	11	worse	bad	JJR
cord-253295-82ydczid	277	12	,	,	,
cord-253295-82ydczid	277	13	an	an	DT
cord-253295-82ydczid	277	14	inaccurate	inaccurate	JJ
cord-253295-82ydczid	277	15	diagnosis	diagnosis	NN
cord-253295-82ydczid	277	16	.	.	.
cord-253295-82ydczid	278	1	Empirical	empirical	JJ
cord-253295-82ydczid	278	2	rules	rule	NNS
cord-253295-82ydczid	278	3	have	have	VBP
cord-253295-82ydczid	278	4	been	be	VBN
cord-253295-82ydczid	278	5	adopted	adopt	VBN
cord-253295-82ydczid	278	6	over	over	IN
cord-253295-82ydczid	278	7	the	the	DT
cord-253295-82ydczid	278	8	decades	decade	NNS
cord-253295-82ydczid	278	9	to	to	TO
cord-253295-82ydczid	278	10	ensure	ensure	VB
cord-253295-82ydczid	278	11	statistically	statistically	RB
cord-253295-82ydczid	278	12	adequate	adequate	JJ
cord-253295-82ydczid	278	13	sampling	sampling	NN
cord-253295-82ydczid	278	14	of	of	IN
cord-253295-82ydczid	278	15	masses	masse	NNS
cord-253295-82ydczid	278	16	and	and	CC
cord-253295-82ydczid	278	17	organs	organ	NNS
cord-253295-82ydczid	278	18	,	,	,
cord-253295-82ydczid	278	19	e.g.	e.g.	RB
cord-253295-82ydczid	278	20	transurethral	transurethral	NN
cord-253295-82ydczid	278	21	resections	resection	NNS
cord-253295-82ydczid	278	22	of	of	IN
cord-253295-82ydczid	278	23	prostate	prostate	NN
cord-253295-82ydczid	278	24	,	,	,
cord-253295-82ydczid	278	25	soft	soft	JJ
cord-253295-82ydczid	278	26	tissue	tissue	NN
cord-253295-82ydczid	278	27	sarcomas	sarcoma	NNS
cord-253295-82ydczid	278	28	,	,	,
cord-253295-82ydczid	278	29	and	and	CC
cord-253295-82ydczid	278	30	heart	heart	NN
cord-253295-82ydczid	278	31	allograft	allograft	NN
cord-253295-82ydczid	278	32	biopsies	biopsy	NNS
cord-253295-82ydczid	278	33	.	.	.
cord-253295-82ydczid	279	1	In	in	IN
cord-253295-82ydczid	279	2	spite	spite	NN
cord-253295-82ydczid	279	3	of	of	IN
cord-253295-82ydczid	279	4	the	the	DT
cord-253295-82ydczid	279	5	limitations	limitation	NNS
cord-253295-82ydczid	279	6	and	and	CC
cord-253295-82ydczid	279	7	statistical	statistical	JJ
cord-253295-82ydczid	279	8	uncertainties	uncertainty	NNS
cord-253295-82ydczid	279	9	relating	relate	VBG
cord-253295-82ydczid	279	10	to	to	IN
cord-253295-82ydczid	279	11	morphologic	morphologic	JJ
cord-253295-82ydczid	279	12	diagnosis	diagnosis	NN
cord-253295-82ydczid	279	13	,	,	,
cord-253295-82ydczid	279	14	a	a	DT
cord-253295-82ydczid	279	15	wealth	wealth	NN
cord-253295-82ydczid	279	16	of	of	IN
cord-253295-82ydczid	279	17	information	information	NN
cord-253295-82ydczid	279	18	is	be	VBZ
cord-253295-82ydczid	279	19	conveyed	convey	VBN
cord-253295-82ydczid	279	20	to	to	IN
cord-253295-82ydczid	279	21	a	a	DT
cord-253295-82ydczid	279	22	service	service	NN
cord-253295-82ydczid	279	23	pathologist	pathologist	NN
cord-253295-82ydczid	279	24	in	in	IN
cord-253295-82ydczid	279	25	a	a	DT
cord-253295-82ydczid	279	26	tried	try	VBN
cord-253295-82ydczid	279	27	-	-	HYPH
cord-253295-82ydczid	279	28	and	and	CC
cord-253295-82ydczid	279	29	-	-	HYPH
cord-253295-82ydczid	279	30	true	true	JJ
cord-253295-82ydczid	279	31	H&E	H&E	NNP
cord-253295-82ydczid	279	32	section	section	NN
cord-253295-82ydczid	279	33	.	.	.
cord-253295-82ydczid	280	1	Analogous	analogous	JJ
cord-253295-82ydczid	280	2	to	to	IN
cord-253295-82ydczid	280	3	the	the	DT
cord-253295-82ydczid	280	4	fact	fact	NN
cord-253295-82ydczid	280	5	that	that	IN
cord-253295-82ydczid	280	6	a	a	DT
cord-253295-82ydczid	280	7	plain	plain	JJ
cord-253295-82ydczid	280	8	chest	chest	NN
cord-253295-82ydczid	280	9	X	x	NN
cord-253295-82ydczid	280	10	-	-	NN
cord-253295-82ydczid	280	11	ray	ray	NN
cord-253295-82ydczid	280	12	is	be	VBZ
cord-253295-82ydczid	280	13	the	the	DT
cord-253295-82ydczid	280	14	sum	sum	NN
cord-253295-82ydczid	280	15	total	total	NN
cord-253295-82ydczid	280	16	of	of	IN
cord-253295-82ydczid	280	17	all	all	DT
cord-253295-82ydczid	280	18	densities	density	NNS
cord-253295-82ydczid	280	19	in	in	IN
cord-253295-82ydczid	280	20	the	the	DT
cord-253295-82ydczid	280	21	beam	beam	NN
cord-253295-82ydczid	280	22	path	path	NN
cord-253295-82ydczid	280	23	,	,	,
cord-253295-82ydczid	280	24	the	the	DT
cord-253295-82ydczid	280	25	morphologic	morphologic	JJ
cord-253295-82ydczid	280	26	changes	change	NNS
cord-253295-82ydczid	280	27	in	in	IN
cord-253295-82ydczid	280	28	diseased	diseased	JJ
cord-253295-82ydczid	280	29	cells	cell	NNS
cord-253295-82ydczid	280	30	and	and	CC
cord-253295-82ydczid	280	31	tissues	tissue	NNS
cord-253295-82ydczid	280	32	are	be	VBP
cord-253295-82ydczid	280	33	the	the	DT
cord-253295-82ydczid	280	34	morphologic	morphologic	JJ
cord-253295-82ydczid	280	35	sum	sum	NN
cord-253295-82ydczid	280	36	total	total	NN
cord-253295-82ydczid	280	37	of	of	IN
cord-253295-82ydczid	280	38	all	all	DT
cord-253295-82ydczid	280	39	of	of	IN
cord-253295-82ydczid	280	40	the	the	DT
cord-253295-82ydczid	280	41	disequilibria	disequilibria	NNP
cord-253295-82ydczid	280	42	in	in	IN
cord-253295-82ydczid	280	43	the	the	DT
cord-253295-82ydczid	280	44	abnormal	abnormal	JJ
cord-253295-82ydczid	280	45	cells	cell	NNS
cord-253295-82ydczid	280	46	.	.	.
cord-253295-82ydczid	281	1	For	for	IN
cord-253295-82ydczid	281	2	most	most	JJS
cord-253295-82ydczid	281	3	neoplastic	neoplastic	JJ
cord-253295-82ydczid	281	4	diseases	disease	NNS
cord-253295-82ydczid	281	5	,	,	,
cord-253295-82ydczid	281	6	morphologic	morphologic	JJ
cord-253295-82ydczid	281	7	criteria	criterion	NNS
cord-253295-82ydczid	281	8	are	be	VBP
cord-253295-82ydczid	281	9	sufficient	sufficient	JJ
cord-253295-82ydczid	281	10	to	to	TO
cord-253295-82ydczid	281	11	predict	predict	VB
cord-253295-82ydczid	281	12	the	the	DT
cord-253295-82ydczid	281	13	risk	risk	NN
cord-253295-82ydczid	281	14	of	of	IN
cord-253295-82ydczid	281	15	invasion	invasion	NN
cord-253295-82ydczid	281	16	and	and	CC
cord-253295-82ydczid	281	17	metastasis	metastasis	NN
cord-253295-82ydczid	281	18	(	(	-LRB-
cord-253295-82ydczid	281	19	the	the	DT
cord-253295-82ydczid	281	20	malignant	malignant	JJ
cord-253295-82ydczid	281	21	potential	potential	NN
cord-253295-82ydczid	281	22	)	)	-RRB-
cord-253295-82ydczid	281	23	,	,	,
cord-253295-82ydczid	281	24	the	the	DT
cord-253295-82ydczid	281	25	pattern	pattern	NN
cord-253295-82ydczid	281	26	of	of	IN
cord-253295-82ydczid	281	27	metastases	metastasis	NNS
cord-253295-82ydczid	281	28	,	,	,
cord-253295-82ydczid	281	29	and	and	CC
cord-253295-82ydczid	281	30	the	the	DT
cord-253295-82ydczid	281	31	likely	likely	JJ
cord-253295-82ydczid	281	32	clinical	clinical	JJ
cord-253295-82ydczid	281	33	outcomes	outcome	NNS
cord-253295-82ydczid	281	34	.	.	.
cord-253295-82ydczid	282	1	For	for	IN
cord-253295-82ydczid	282	2	example	example	NN
cord-253295-82ydczid	282	3	,	,	,
cord-253295-82ydczid	282	4	the	the	DT
cord-253295-82ydczid	282	5	etiology	etiology	NN
cord-253295-82ydczid	282	6	and	and	CC
cord-253295-82ydczid	282	7	pathogenesis	pathogenesis	NN
cord-253295-82ydczid	282	8	in	in	IN
cord-253295-82ydczid	282	9	small	small	JJ
cord-253295-82ydczid	282	10	cell	cell	NN
cord-253295-82ydczid	282	11	lung	lung	NN
cord-253295-82ydczid	282	12	carcinoma	carcinoma	NN
cord-253295-82ydczid	282	13	can	can	MD
cord-253295-82ydczid	282	14	be	be	VB
cord-253295-82ydczid	282	15	inferred	infer	VBN
cord-253295-82ydczid	282	16	(	(	-LRB-
cord-253295-82ydczid	282	17	cigarette	cigarette	NN
cord-253295-82ydczid	282	18	smoking	smoking	NN
cord-253295-82ydczid	282	19	,	,	,
cord-253295-82ydczid	282	20	with	with	IN
cord-253295-82ydczid	282	21	carcinogen	carcinogen	NN
cord-253295-82ydczid	282	22	-	-	HYPH
cord-253295-82ydczid	282	23	induced	induce	VBN
cord-253295-82ydczid	282	24	genetic	genetic	JJ
cord-253295-82ydczid	282	25	mutations	mutation	NNS
cord-253295-82ydczid	282	26	)	)	-RRB-
cord-253295-82ydczid	282	27	and	and	CC
cord-253295-82ydczid	282	28	the	the	DT
cord-253295-82ydczid	282	29	outcome	outcome	NN
cord-253295-82ydczid	282	30	predicted	predict	VBD
cord-253295-82ydczid	282	31	(	(	-LRB-
cord-253295-82ydczid	282	32	early	early	JJ
cord-253295-82ydczid	282	33	metastasis	metastasis	NN
cord-253295-82ydczid	282	34	to	to	IN
cord-253295-82ydczid	282	35	regional	regional	JJ
cord-253295-82ydczid	282	36	nodes	node	NNS
cord-253295-82ydczid	282	37	and	and	CC
cord-253295-82ydczid	282	38	distant	distant	JJ
cord-253295-82ydczid	282	39	organs	organ	NNS
cord-253295-82ydczid	282	40	,	,	,
cord-253295-82ydczid	282	41	with	with	IN
cord-253295-82ydczid	282	42	high	high	JJ
cord-253295-82ydczid	282	43	probability	probability	NN
cord-253295-82ydczid	282	44	of	of	IN
cord-253295-82ydczid	282	45	death	death	NN
cord-253295-82ydczid	282	46	within	within	IN
cord-253295-82ydczid	282	47	5	5	CD
cord-253295-82ydczid	282	48	years	year	NNS
cord-253295-82ydczid	282	49	of	of	IN
cord-253295-82ydczid	282	50	diagnosis	diagnosis	NN
cord-253295-82ydczid	282	51	)	)	-RRB-
cord-253295-82ydczid	282	52	.	.	.
cord-253295-82ydczid	283	1	New	new	JJ
cord-253295-82ydczid	283	2	molecular	molecular	JJ
cord-253295-82ydczid	283	3	data	datum	NNS
cord-253295-82ydczid	283	4	for	for	IN
cord-253295-82ydczid	283	5	both	both	CC
cord-253295-82ydczid	283	6	neoplastic	neoplastic	JJ
cord-253295-82ydczid	283	7	and	and	CC
cord-253295-82ydczid	283	8	non	non	JJ
cord-253295-82ydczid	283	9	-	-	JJ
cord-253295-82ydczid	283	10	neoplastic	neoplastic	JJ
cord-253295-82ydczid	283	11	diseases	disease	NNS
cord-253295-82ydczid	283	12	will	will	MD
cord-253295-82ydczid	283	13	most	most	RBS
cord-253295-82ydczid	283	14	likely	likely	RB
cord-253295-82ydczid	283	15	benefit	benefit	VB
cord-253295-82ydczid	283	16	unaffected	unaffected	JJ
cord-253295-82ydczid	283	17	individuals	individual	NNS
cord-253295-82ydczid	283	18	by	by	IN
cord-253295-82ydczid	283	19	estimating	estimate	VBG
cord-253295-82ydczid	283	20	disease	disease	NN
cord-253295-82ydczid	283	21	risk	risk	NN
cord-253295-82ydczid	283	22	,	,	,
cord-253295-82ydczid	283	23	and	and	CC
cord-253295-82ydczid	283	24	will	will	MD
cord-253295-82ydczid	283	25	most	most	RBS
cord-253295-82ydczid	283	26	likely	likely	JJ
cord-253295-82ydczid	283	27	benefit	benefit	VB
cord-253295-82ydczid	283	28	patients	patient	NNS
cord-253295-82ydczid	283	29	by	by	IN
cord-253295-82ydczid	283	30	defining	define	VBG
cord-253295-82ydczid	283	31	the	the	DT
cord-253295-82ydczid	283	32	molecular	molecular	JJ
cord-253295-82ydczid	283	33	subset	subset	VBN
cord-253295-82ydczid	283	34	for	for	IN
cord-253295-82ydczid	283	35	morphologically	morphologically	RB
cord-253295-82ydczid	283	36	defined	define	VBN
cord-253295-82ydczid	283	37	diagnostic	diagnostic	JJ
cord-253295-82ydczid	283	38	entities	entity	NNS
cord-253295-82ydczid	283	39	,	,	,
cord-253295-82ydczid	283	40	thus	thus	RB
cord-253295-82ydczid	283	41	guiding	guide	VBG
cord-253295-82ydczid	283	42	individualized	individualized	JJ
cord-253295-82ydczid	283	43	therapy	therapy	NN
cord-253295-82ydczid	283	44	.	.	.
cord-253295-82ydczid	284	1	Diagnostic	diagnostic	JJ
cord-253295-82ydczid	284	2	pathology	pathology	NN
cord-253295-82ydczid	284	3	will	will	MD
cord-253295-82ydczid	284	4	continue	continue	VB
cord-253295-82ydczid	284	5	to	to	TO
cord-253295-82ydczid	284	6	use	use	VB
cord-253295-82ydczid	284	7	morphology	morphology	NN
cord-253295-82ydczid	284	8	and	and	CC
cord-253295-82ydczid	284	9	complementary	complementary	JJ
cord-253295-82ydczid	284	10	data	datum	NNS
cord-253295-82ydczid	284	11	from	from	IN
cord-253295-82ydczid	284	12	protein	protein	NN
cord-253295-82ydczid	284	13	(	(	-LRB-
cord-253295-82ydczid	284	14	immunohistochemical	immunohistochemical	JJ
cord-253295-82ydczid	284	15	)	)	-RRB-
cord-253295-82ydczid	284	16	and	and	CC
cord-253295-82ydczid	284	17	nucleic	nucleic	JJ
cord-253295-82ydczid	284	18	acid	acid	NN
cord-253295-82ydczid	284	19	(	(	-LRB-
cord-253295-82ydczid	284	20	cytogenetic	cytogenetic	NN
cord-253295-82ydczid	284	21	,	,	,
cord-253295-82ydczid	284	22	in	in	IN
cord-253295-82ydczid	284	23	situ	situ	NN
cord-253295-82ydczid	284	24	hybridization	hybridization	NN
cord-253295-82ydczid	284	25	,	,	,
cord-253295-82ydczid	284	26	DNA	dna	NN
cord-253295-82ydczid	284	27	sequence	sequence	NN
cord-253295-82ydczid	284	28	,	,	,
cord-253295-82ydczid	284	29	epigenetic	epigenetic	JJ
cord-253295-82ydczid	284	30	,	,	,
cord-253295-82ydczid	284	31	and	and	CC
cord-253295-82ydczid	284	32	RNA	RNA	NNP
cord-253295-82ydczid	284	33	abundance	abundance	NN
cord-253295-82ydczid	284	34	)	)	-RRB-
cord-253295-82ydczid	284	35	screening	screening	NN
cord-253295-82ydczid	284	36	assays	assay	NNS
cord-253295-82ydczid	284	37	.	.	.
cord-253295-82ydczid	285	1	Improvements	improvement	NNS
cord-253295-82ydczid	285	2	in	in	IN
cord-253295-82ydczid	285	3	current	current	JJ
cord-253295-82ydczid	285	4	technologies	technology	NNS
cord-253295-82ydczid	285	5	should	should	MD
cord-253295-82ydczid	285	6	improve	improve	VB
cord-253295-82ydczid	285	7	current	current	JJ
cord-253295-82ydczid	285	8	test	test	NN
cord-253295-82ydczid	285	9	performance	performance	NN
cord-253295-82ydczid	285	10	,	,	,
cord-253295-82ydczid	285	11	reduce	reduce	VB
cord-253295-82ydczid	285	12	test	test	NN
cord-253295-82ydczid	285	13	cost	cost	NN
cord-253295-82ydczid	285	14	,	,	,
cord-253295-82ydczid	285	15	and	and	CC
cord-253295-82ydczid	285	16	shorten	shorten	VB
cord-253295-82ydczid	285	17	turnaround	turnaround	NN
cord-253295-82ydczid	285	18	time	time	NN
cord-253295-82ydczid	285	19	.	.	.
cord-253295-82ydczid	286	1	Development	development	NN
cord-253295-82ydczid	286	2	of	of	IN
cord-253295-82ydczid	286	3	new	new	JJ
cord-253295-82ydczid	286	4	technologies	technology	NNS
cord-253295-82ydczid	286	5	will	will	MD
cord-253295-82ydczid	286	6	lead	lead	VB
cord-253295-82ydczid	286	7	to	to	IN
cord-253295-82ydczid	286	8	better	well	JJR
cord-253295-82ydczid	286	9	diagnostic	diagnostic	JJ
cord-253295-82ydczid	286	10	algorithms	algorithm	NNS
cord-253295-82ydczid	286	11	,	,	,
cord-253295-82ydczid	286	12	improved	improve	VBN
cord-253295-82ydczid	286	13	diagnostic	diagnostic	JJ
cord-253295-82ydczid	286	14	accuracy	accuracy	NN
cord-253295-82ydczid	286	15	and	and	CC
cord-253295-82ydczid	286	16	prognosis	prognosis	NN
cord-253295-82ydczid	286	17	,	,	,
cord-253295-82ydczid	286	18	improved	improve	VBN
cord-253295-82ydczid	286	19	patient	patient	JJ
cord-253295-82ydczid	286	20	assignment	assignment	NN
cord-253295-82ydczid	286	21	to	to	IN
cord-253295-82ydczid	286	22	prospective	prospective	JJ
cord-253295-82ydczid	286	23	randomized	randomized	JJ
cord-253295-82ydczid	286	24	clinical	clinical	JJ
cord-253295-82ydczid	286	25	trials	trial	NNS
cord-253295-82ydczid	286	26	,	,	,
cord-253295-82ydczid	286	27	improved	improved	JJ
cord-253295-82ydczid	286	28	prediction	prediction	NN
cord-253295-82ydczid	286	29	of	of	IN
cord-253295-82ydczid	286	30	response	response	NN
cord-253295-82ydczid	286	31	to	to	IN
cord-253295-82ydczid	286	32	customized	customize	VBN
cord-253295-82ydczid	286	33	therapy	therapy	NN
cord-253295-82ydczid	286	34	,	,	,
cord-253295-82ydczid	286	35	and	and	CC
cord-253295-82ydczid	286	36	improved	improve	VBN
cord-253295-82ydczid	286	37	sensitivity	sensitivity	NN
cord-253295-82ydczid	286	38	for	for	IN
cord-253295-82ydczid	286	39	measurement	measurement	NN
cord-253295-82ydczid	286	40	of	of	IN
cord-253295-82ydczid	286	41	residual	residual	JJ
cord-253295-82ydczid	286	42	subclinical	subclinical	JJ
cord-253295-82ydczid	286	43	disease	disease	NN
cord-253295-82ydczid	286	44	.	.	.
cord-253295-82ydczid	287	1	For	for	IN
cord-253295-82ydczid	287	2	transplant	transplant	NN
cord-253295-82ydczid	287	3	candidates	candidate	NNS
cord-253295-82ydczid	287	4	,	,	,
cord-253295-82ydczid	287	5	major	major	JJ
cord-253295-82ydczid	287	6	histocompatability	histocompatability	NN
cord-253295-82ydczid	287	7	complex	complex	NN
cord-253295-82ydczid	287	8	(	(	-LRB-
cord-253295-82ydczid	287	9	MHC	MHC	NNP
cord-253295-82ydczid	287	10	,	,	,
cord-253295-82ydczid	287	11	HLA	HLA	NNP
cord-253295-82ydczid	287	12	in	in	IN
cord-253295-82ydczid	287	13	human	human	JJ
cord-253295-82ydczid	287	14	)	)	-RRB-
cord-253295-82ydczid	287	15	screening	screening	NN
cord-253295-82ydczid	287	16	is	be	VBZ
cord-253295-82ydczid	287	17	evolving	evolve	VBG
cord-253295-82ydczid	287	18	from	from	IN
cord-253295-82ydczid	287	19	cellular	cellular	JJ
cord-253295-82ydczid	287	20	assays	assay	NNS
cord-253295-82ydczid	287	21	and	and	CC
cord-253295-82ydczid	287	22	serology	serology	NN
cord-253295-82ydczid	287	23	toward	toward	IN
cord-253295-82ydczid	287	24	sequencing	sequencing	NN
cord-253295-82ydczid	287	25	of	of	IN
cord-253295-82ydczid	287	26	the	the	DT
cord-253295-82ydczid	287	27	alleles	allele	NNS
cord-253295-82ydczid	287	28	of	of	IN
cord-253295-82ydczid	287	29	the	the	DT
cord-253295-82ydczid	287	30	class	class	NN
cord-253295-82ydczid	287	31	I	i	NN
cord-253295-82ydczid	287	32	and	and	CC
cord-253295-82ydczid	287	33	II	II	NNP
cord-253295-82ydczid	287	34	HLA	HLA	NNP
cord-253295-82ydczid	287	35	loci	locus	NNS
cord-253295-82ydczid	287	36	.	.	.
cord-253295-82ydczid	288	1	Rapid	rapid	JJ
cord-253295-82ydczid	288	2	sequencing	sequencing	NN
cord-253295-82ydczid	288	3	of	of	IN
cord-253295-82ydczid	288	4	these	these	DT
cord-253295-82ydczid	288	5	alleles	allele	NNS
cord-253295-82ydczid	288	6	in	in	IN
cord-253295-82ydczid	288	7	newborn	newborn	JJ
cord-253295-82ydczid	288	8	cord	cord	NN
cord-253295-82ydczid	288	9	blood	blood	NN
cord-253295-82ydczid	288	10	would	would	MD
cord-253295-82ydczid	288	11	allow	allow	VB
cord-253295-82ydczid	288	12	creation	creation	NN
cord-253295-82ydczid	288	13	of	of	IN
cord-253295-82ydczid	288	14	a	a	DT
cord-253295-82ydczid	288	15	database	database	NN
cord-253295-82ydczid	288	16	of	of	IN
cord-253295-82ydczid	288	17	the	the	DT
cord-253295-82ydczid	288	18	population	population	NN
cord-253295-82ydczid	288	19	's	's	POS
cord-253295-82ydczid	288	20	haplotypes	haplotype	NNS
cord-253295-82ydczid	288	21	,	,	,
cord-253295-82ydczid	288	22	facilitating	facilitate	VBG
cord-253295-82ydczid	288	23	perfect	perfect	JJ
cord-253295-82ydczid	288	24	matches	match	NNS
cord-253295-82ydczid	288	25	for	for	IN
cord-253295-82ydczid	288	26	required	require	VBN
cord-253295-82ydczid	288	27	bone	bone	NN
cord-253295-82ydczid	288	28	marrow	marrow	NN
cord-253295-82ydczid	288	29	or	or	CC
cord-253295-82ydczid	288	30	solid	solid	JJ
cord-253295-82ydczid	288	31	organ	organ	NN
cord-253295-82ydczid	288	32	transplants	transplant	NNS
cord-253295-82ydczid	288	33	.	.	.
cord-253295-82ydczid	289	1	Current	current	JJ
cord-253295-82ydczid	289	2	uses	use	NNS
cord-253295-82ydczid	289	3	of	of	IN
cord-253295-82ydczid	289	4	in	in	IN
cord-253295-82ydczid	289	5	situ	situ	JJ
cord-253295-82ydczid	289	6	hybridization	hybridization	NN
cord-253295-82ydczid	289	7	to	to	TO
cord-253295-82ydczid	289	8	screen	screen	VB
cord-253295-82ydczid	289	9	for	for	IN
cord-253295-82ydczid	289	10	viruses	virus	NNS
cord-253295-82ydczid	289	11	(	(	-LRB-
cord-253295-82ydczid	289	12	such	such	JJ
cord-253295-82ydczid	289	13	as	as	IN
cord-253295-82ydczid	289	14	EBV	EBV	NNP
cord-253295-82ydczid	289	15	)	)	-RRB-
cord-253295-82ydczid	290	1	,	,	,
cord-253295-82ydczid	290	2	light	light	JJ
cord-253295-82ydczid	290	3	chain	chain	NN
cord-253295-82ydczid	290	4	restriction	restriction	NN
cord-253295-82ydczid	290	5	(	(	-LRB-
cord-253295-82ydczid	290	6	in	in	IN
cord-253295-82ydczid	290	7	B	b	NN
cord-253295-82ydczid	290	8	lymphomas	lymphoma	NNS
cord-253295-82ydczid	290	9	)	)	-RRB-
cord-253295-82ydczid	290	10	,	,	,
cord-253295-82ydczid	290	11	and	and	CC
cord-253295-82ydczid	290	12	copy	copy	NN
cord-253295-82ydczid	290	13	number	number	NN
cord-253295-82ydczid	290	14	variation	variation	NN
cord-253295-82ydczid	290	15	(	(	-LRB-
cord-253295-82ydczid	290	16	for	for	IN
cord-253295-82ydczid	290	17	instance	instance	NN
cord-253295-82ydczid	290	18	,	,	,
cord-253295-82ydczid	290	19	HER2	HER2	NNP
cord-253295-82ydczid	290	20	gene	gene	NN
cord-253295-82ydczid	290	21	amplification	amplification	NN
cord-253295-82ydczid	290	22	)	)	-RRB-
cord-253295-82ydczid	290	23	demonstrate	demonstrate	VBP
cord-253295-82ydczid	290	24	the	the	DT
cord-253295-82ydczid	290	25	benefit	benefit	NN
cord-253295-82ydczid	290	26	of	of	IN
cord-253295-82ydczid	290	27	in	in	IN
cord-253295-82ydczid	290	28	situ	situ	JJ
cord-253295-82ydczid	290	29	nucleic	nucleic	JJ
cord-253295-82ydczid	290	30	acid	acid	NN
cord-253295-82ydczid	290	31	hybridization	hybridization	NN
cord-253295-82ydczid	290	32	assays	assay	NNS
cord-253295-82ydczid	290	33	.	.	.
cord-253295-82ydczid	291	1	Interphase	interphase	NN
cord-253295-82ydczid	291	2	in	in	IN
cord-253295-82ydczid	291	3	situ	situ	NN
cord-253295-82ydczid	291	4	hybridization	hybridization	NN
cord-253295-82ydczid	291	5	with	with	IN
cord-253295-82ydczid	291	6	fluorescent	fluorescent	JJ
cord-253295-82ydczid	291	7	probes	probe	NNS
cord-253295-82ydczid	291	8	(	(	-LRB-
cord-253295-82ydczid	291	9	FISH	FISH	NNP
cord-253295-82ydczid	291	10	)	)	-RRB-
cord-253295-82ydczid	291	11	is	be	VBZ
cord-253295-82ydczid	291	12	now	now	RB
cord-253295-82ydczid	291	13	being	be	VBG
cord-253295-82ydczid	291	14	used	use	VBN
cord-253295-82ydczid	291	15	in	in	IN
cord-253295-82ydczid	291	16	the	the	DT
cord-253295-82ydczid	291	17	initial	initial	JJ
cord-253295-82ydczid	291	18	diagnostic	diagnostic	JJ
cord-253295-82ydczid	291	19	workup	workup	NN
cord-253295-82ydczid	291	20	for	for	IN
cord-253295-82ydczid	291	21	certain	certain	JJ
cord-253295-82ydczid	291	22	diseases	disease	NNS
cord-253295-82ydczid	291	23	,	,	,
cord-253295-82ydczid	291	24	e.g.	e.g.	RB
cord-253295-82ydczid	291	25	sarcoma	sarcoma	NN
cord-253295-82ydczid	291	26	-	-	HYPH
cord-253295-82ydczid	291	27	specific	specific	JJ
cord-253295-82ydczid	291	28	translocations	translocation	NNS
cord-253295-82ydczid	291	29	,	,	,
cord-253295-82ydczid	291	30	ploidy	ploidy	NN
cord-253295-82ydczid	291	31	analysis	analysis	NN
cord-253295-82ydczid	291	32	in	in	IN
cord-253295-82ydczid	291	33	hydatidiform	hydatidiform	NNP
cord-253295-82ydczid	291	34	moles	mole	NNS
cord-253295-82ydczid	291	35	,	,	,
cord-253295-82ydczid	291	36	and	and	CC
cord-253295-82ydczid	291	37	copy	copy	NN
cord-253295-82ydczid	291	38	number	number	NN
cord-253295-82ydczid	291	39	variation	variation	NN
cord-253295-82ydczid	291	40	analysis	analysis	NN
cord-253295-82ydczid	291	41	for	for	IN
cord-253295-82ydczid	291	42	detection	detection	NN
cord-253295-82ydczid	291	43	of	of	IN
cord-253295-82ydczid	291	44	locus	locus	NN
cord-253295-82ydczid	291	45	amplification	amplification	NN
cord-253295-82ydczid	291	46	and	and	CC
cord-253295-82ydczid	291	47	deletion	deletion	NN
cord-253295-82ydczid	291	48	.	.	.
cord-253295-82ydczid	292	1	Rapid	rapid	JJ
cord-253295-82ydczid	292	2	DNA	dna	NN
cord-253295-82ydczid	292	3	sequence	sequence	NN
cord-253295-82ydczid	292	4	,	,	,
cord-253295-82ydczid	292	5	RNA	RNA	NNP
cord-253295-82ydczid	292	6	sequence	sequence	NN
cord-253295-82ydczid	292	7	,	,	,
cord-253295-82ydczid	292	8	and	and	CC
cord-253295-82ydczid	292	9	RNA	RNA	NNP
cord-253295-82ydczid	292	10	abundance	abundance	NN
cord-253295-82ydczid	292	11	screening	screen	VBG
cord-253295-82ydczid	292	12	Current	current	JJ
cord-253295-82ydczid	292	13	uses	use	NNS
cord-253295-82ydczid	292	14	of	of	IN
cord-253295-82ydczid	292	15	DNA	dna	NN
cord-253295-82ydczid	292	16	screening	screening	NN
cord-253295-82ydczid	292	17	for	for	IN
cord-253295-82ydczid	292	18	BCR	BCR	NNP
cord-253295-82ydczid	292	19	-	-	HYPH
cord-253295-82ydczid	292	20	ABL	ABL	NNP
cord-253295-82ydczid	292	21	translocation	translocation	NN
cord-253295-82ydczid	292	22	,	,	,
cord-253295-82ydczid	292	23	donor	donor	NN
cord-253295-82ydczid	292	24	:	:	:
cord-253295-82ydczid	292	25	recipient	recipient	NN
cord-253295-82ydczid	292	26	ratios	ratio	NNS
cord-253295-82ydczid	292	27	after	after	IN
cord-253295-82ydczid	292	28	allogeneic	allogeneic	NN
cord-253295-82ydczid	292	29	bone	bone	NN
cord-253295-82ydczid	292	30	marrow	marrow	NN
cord-253295-82ydczid	292	31	transplant	transplant	NN
cord-253295-82ydczid	292	32	,	,	,
cord-253295-82ydczid	292	33	microsatellite	microsatellite	JJ
cord-253295-82ydczid	292	34	instability	instability	NN
cord-253295-82ydczid	292	35	,	,	,
cord-253295-82ydczid	292	36	quantitative	quantitative	JJ
cord-253295-82ydczid	292	37	viral	viral	JJ
cord-253295-82ydczid	292	38	load	load	NN
cord-253295-82ydczid	292	39	(	(	-LRB-
cord-253295-82ydczid	292	40	e.g.	e.g.	RB
cord-253295-82ydczid	292	41	EBV	EBV	NNP
cord-253295-82ydczid	292	42	,	,	,
cord-253295-82ydczid	292	43	BK	BK	NNP
cord-253295-82ydczid	292	44	,	,	,
cord-253295-82ydczid	292	45	CMV	CMV	NNP
cord-253295-82ydczid	292	46	)	)	-RRB-
cord-253295-82ydczid	292	47	,	,	,
cord-253295-82ydczid	292	48	single	single	JJ
cord-253295-82ydczid	292	49	gene	gene	NN
cord-253295-82ydczid	292	50	mutations	mutation	NNS
cord-253295-82ydczid	292	51	(	(	-LRB-
cord-253295-82ydczid	292	52	e.g.	e.g.	RB
cord-253295-82ydczid	292	53	CFTR	CFTR	NNP
cord-253295-82ydczid	292	54	,	,	,
cord-253295-82ydczid	292	55	Factor	factor	NN
cord-253295-82ydczid	292	56	2	2	CD
cord-253295-82ydczid	292	57	,	,	,
cord-253295-82ydczid	292	58	SERPINA1	SERPINA1	NNP
cord-253295-82ydczid	292	59	(	(	-LRB-
cord-253295-82ydczid	292	60	α-1-antitrypsin	α-1-antitrypsin	NNP
cord-253295-82ydczid	292	61	)	)	-RRB-
cord-253295-82ydczid	292	62	,	,	,
cord-253295-82ydczid	292	63	HFE	HFE	NNP
cord-253295-82ydczid	292	64	)	)	-RRB-
cord-253295-82ydczid	292	65	,	,	,
cord-253295-82ydczid	292	66	and	and	CC
cord-253295-82ydczid	292	67	promoter	promoter	NN
cord-253295-82ydczid	292	68	methylation	methylation	NN
cord-253295-82ydczid	292	69	(	(	-LRB-
cord-253295-82ydczid	292	70	e.g.	e.g.	RB
cord-253295-82ydczid	292	71	MLH1	MLH1	NNP
cord-253295-82ydczid	292	72	,	,	,
cord-253295-82ydczid	292	73	MGMT	MGMT	NNP
cord-253295-82ydczid	292	74	)	)	-RRB-
cord-253295-82ydczid	292	75	demonstrate	demonstrate	VBP
cord-253295-82ydczid	292	76	the	the	DT
cord-253295-82ydczid	292	77	benefit	benefit	NN
cord-253295-82ydczid	292	78	of	of	IN
cord-253295-82ydczid	292	79	nucleic	nucleic	JJ
cord-253295-82ydczid	292	80	acid	acid	NN
cord-253295-82ydczid	292	81	screening	screening	NN
cord-253295-82ydczid	292	82	in	in	IN
cord-253295-82ydczid	292	83	diagnosis	diagnosis	NN
cord-253295-82ydczid	292	84	and	and	CC
cord-253295-82ydczid	292	85	management	management	NN
cord-253295-82ydczid	292	86	.	.	.
cord-253295-82ydczid	293	1	It	-PRON-	PRP
cord-253295-82ydczid	293	2	is	be	VBZ
cord-253295-82ydczid	293	3	likely	likely	JJ
cord-253295-82ydczid	293	4	that	that	IN
cord-253295-82ydczid	293	5	each	each	DT
cord-253295-82ydczid	293	6	new	new	JJ
cord-253295-82ydczid	293	7	malignant	malignant	JJ
cord-253295-82ydczid	293	8	neoplasm	neoplasm	NN
cord-253295-82ydczid	293	9	will	will	MD
cord-253295-82ydczid	293	10	be	be	VB
cord-253295-82ydczid	293	11	promptly	promptly	RB
cord-253295-82ydczid	293	12	inventoried	inventorie	VBN
cord-253295-82ydczid	293	13	for	for	IN
cord-253295-82ydczid	293	14	chromosomal	chromosomal	JJ
cord-253295-82ydczid	293	15	ploidy	ploidy	NN
cord-253295-82ydczid	293	16	,	,	,
cord-253295-82ydczid	293	17	gene	gene	NN
cord-253295-82ydczid	293	18	translocations	translocation	NNS
cord-253295-82ydczid	293	19	,	,	,
cord-253295-82ydczid	293	20	gene	gene	NN
cord-253295-82ydczid	293	21	copy	copy	NN
cord-253295-82ydczid	293	22	number	number	NN
cord-253295-82ydczid	293	23	variation	variation	NN
cord-253295-82ydczid	293	24	,	,	,
cord-253295-82ydczid	293	25	DNA	dna	NN
cord-253295-82ydczid	293	26	base	base	NN
cord-253295-82ydczid	293	27	substitutions	substitution	NNS
cord-253295-82ydczid	293	28	/	/	SYM
cord-253295-82ydczid	293	29	insertions	insertion	NNS
cord-253295-82ydczid	293	30	/	/	SYM
cord-253295-82ydczid	293	31	deletions	deletion	NNS
cord-253295-82ydczid	293	32	,	,	,
cord-253295-82ydczid	293	33	annotation	annotation	NN
cord-253295-82ydczid	293	34	of	of	IN
cord-253295-82ydczid	293	35	non	non	JJ
cord-253295-82ydczid	293	36	-	-	JJ
cord-253295-82ydczid	293	37	synonymous	synonymous	JJ
cord-253295-82ydczid	293	38	coding	code	VBG
cord-253295-82ydczid	293	39	sequence	sequence	NN
cord-253295-82ydczid	293	40	and	and	CC
cord-253295-82ydczid	293	41	splice	splice	NN
cord-253295-82ydczid	293	42	-	-	HYPH
cord-253295-82ydczid	293	43	site	site	NN
cord-253295-82ydczid	293	44	changes	change	NNS
cord-253295-82ydczid	293	45	as	as	IN
cord-253295-82ydczid	293	46	either	either	CC
cord-253295-82ydczid	293	47	benign	benign	JJ
cord-253295-82ydczid	293	48	polymorphisms	polymorphism	NNS
cord-253295-82ydczid	293	49	or	or	CC
cord-253295-82ydczid	293	50	pathogenic	pathogenic	JJ
cord-253295-82ydczid	293	51	mutations	mutation	NNS
cord-253295-82ydczid	293	52	,	,	,
cord-253295-82ydczid	293	53	local	local	JJ
cord-253295-82ydczid	293	54	and	and	CC
cord-253295-82ydczid	293	55	global	global	JJ
cord-253295-82ydczid	293	56	promoter	promoter	NN
cord-253295-82ydczid	293	57	methylation	methylation	NN
cord-253295-82ydczid	293	58	status	status	NN
cord-253295-82ydczid	293	59	,	,	,
cord-253295-82ydczid	293	60	and	and	CC
cord-253295-82ydczid	293	61	RNA	RNA	NNP
cord-253295-82ydczid	293	62	expression	expression	NN
cord-253295-82ydczid	293	63	cluster	cluster	NN
cord-253295-82ydczid	293	64	subset	subset	VBN
cord-253295-82ydczid	293	65	.	.	.
cord-253295-82ydczid	294	1	This	this	DT
cord-253295-82ydczid	294	2	inventory	inventory	NN
cord-253295-82ydczid	294	3	at	at	IN
cord-253295-82ydczid	294	4	the	the	DT
cord-253295-82ydczid	294	5	time	time	NN
cord-253295-82ydczid	294	6	of	of	IN
cord-253295-82ydczid	294	7	initial	initial	JJ
cord-253295-82ydczid	294	8	diagnosis	diagnosis	NN
cord-253295-82ydczid	294	9	,	,	,
cord-253295-82ydczid	294	10	prior	prior	RB
cord-253295-82ydczid	294	11	to	to	IN
cord-253295-82ydczid	294	12	therapy	therapy	NN
cord-253295-82ydczid	294	13	,	,	,
cord-253295-82ydczid	294	14	should	should	MD
cord-253295-82ydczid	294	15	allow	allow	VB
cord-253295-82ydczid	294	16	molecular	molecular	JJ
cord-253295-82ydczid	294	17	subgrouping	subgrouping	NN
cord-253295-82ydczid	294	18	,	,	,
cord-253295-82ydczid	294	19	individualized	individualized	JJ
cord-253295-82ydczid	294	20	therapy	therapy	NN
cord-253295-82ydczid	294	21	,	,	,
cord-253295-82ydczid	294	22	and	and	CC
cord-253295-82ydczid	294	23	targeted	target	VBN
cord-253295-82ydczid	294	24	residual	residual	JJ
cord-253295-82ydczid	294	25	disease	disease	NN
cord-253295-82ydczid	294	26	screening	screening	NN
cord-253295-82ydczid	294	27	.	.	.
cord-253295-82ydczid	295	1	As	as	IN
cord-253295-82ydczid	295	2	the	the	DT
cord-253295-82ydczid	295	3	cost	cost	NN
cord-253295-82ydczid	295	4	of	of	IN
cord-253295-82ydczid	295	5	genome	genome	NN
cord-253295-82ydczid	295	6	sequencing	sequencing	NN
cord-253295-82ydczid	295	7	approaches	approach	VBZ
cord-253295-82ydczid	295	8	the	the	DT
cord-253295-82ydczid	295	9	$	$	$
cord-253295-82ydczid	295	10	1000	1000	CD
cord-253295-82ydczid	295	11	mark	mark	NN
cord-253295-82ydczid	295	12	,	,	,
cord-253295-82ydczid	295	13	sequencing	sequencing	NN
cord-253295-82ydczid	295	14	of	of	IN
cord-253295-82ydczid	295	15	newborns	newborn	NNS
cord-253295-82ydczid	295	16	for	for	IN
cord-253295-82ydczid	295	17	germline	germline	JJ
cord-253295-82ydczid	295	18	mutations	mutation	NNS
cord-253295-82ydczid	295	19	that	that	WDT
cord-253295-82ydczid	295	20	predispose	predispose	VBP
cord-253295-82ydczid	295	21	to	to	IN
cord-253295-82ydczid	295	22	subsequent	subsequent	JJ
cord-253295-82ydczid	295	23	developmental	developmental	JJ
cord-253295-82ydczid	295	24	or	or	CC
cord-253295-82ydczid	295	25	neoplastic	neoplastic	JJ
cord-253295-82ydczid	295	26	diseases	disease	NNS
cord-253295-82ydczid	295	27	now	now	RB
cord-253295-82ydczid	295	28	seems	seem	VBZ
cord-253295-82ydczid	295	29	practical	practical	JJ
cord-253295-82ydczid	295	30	for	for	IN
cord-253295-82ydczid	295	31	the	the	DT
cord-253295-82ydczid	295	32	purposes	purpose	NNS
cord-253295-82ydczid	295	33	of	of	IN
cord-253295-82ydczid	295	34	early	early	JJ
cord-253295-82ydczid	295	35	diagnosis	diagnosis	NN
cord-253295-82ydczid	295	36	,	,	,
cord-253295-82ydczid	295	37	prompt	prompt	JJ
cord-253295-82ydczid	295	38	management	management	NN
cord-253295-82ydczid	295	39	,	,	,
cord-253295-82ydczid	295	40	and	and	CC
cord-253295-82ydczid	295	41	routine	routine	JJ
cord-253295-82ydczid	295	42	follow	follow	NN
cord-253295-82ydczid	295	43	-	-	HYPH
cord-253295-82ydczid	295	44	up	up	NN
cord-253295-82ydczid	295	45	.	.	.
cord-253295-82ydczid	296	1	Current	current	JJ
cord-253295-82ydczid	296	2	uses	use	NNS
cord-253295-82ydczid	296	3	of	of	IN
cord-253295-82ydczid	296	4	morphology	morphology	NN
cord-253295-82ydczid	296	5	,	,	,
cord-253295-82ydczid	296	6	immunohistochemistry	immunohistochemistry	NN
cord-253295-82ydczid	296	7	,	,	,
cord-253295-82ydczid	296	8	and	and	CC
cord-253295-82ydczid	296	9	molecular	molecular	JJ
cord-253295-82ydczid	296	10	pathology	pathology	NN
cord-253295-82ydczid	296	11	demonstrate	demonstrate	VBP
cord-253295-82ydczid	296	12	their	-PRON-	PRP$
cord-253295-82ydczid	296	13	benefit	benefit	NN
cord-253295-82ydczid	296	14	through	through	IN
cord-253295-82ydczid	296	15	improved	improve	VBN
cord-253295-82ydczid	296	16	diagnostic	diagnostic	JJ
cord-253295-82ydczid	296	17	accuracy	accuracy	NN
cord-253295-82ydczid	296	18	.	.	.
cord-253295-82ydczid	297	1	However	however	RB
cord-253295-82ydczid	297	2	,	,	,
cord-253295-82ydczid	297	3	diagnosis	diagnosis	NN
cord-253295-82ydczid	297	4	,	,	,
cord-253295-82ydczid	297	5	extent	extent	NN
cord-253295-82ydczid	297	6	of	of	IN
cord-253295-82ydczid	297	7	disease	disease	NN
cord-253295-82ydczid	297	8	,	,	,
cord-253295-82ydczid	297	9	and	and	CC
cord-253295-82ydczid	297	10	molecular	molecular	JJ
cord-253295-82ydczid	297	11	subsets	subset	NNS
cord-253295-82ydczid	297	12	are	be	VBP
cord-253295-82ydczid	297	13	currently	currently	RB
cord-253295-82ydczid	297	14	imperfect	imperfect	JJ
cord-253295-82ydczid	297	15	estimators	estimator	NNS
cord-253295-82ydczid	297	16	of	of	IN
cord-253295-82ydczid	297	17	prognosis	prognosis	NN
cord-253295-82ydczid	297	18	and	and	CC
cord-253295-82ydczid	297	19	response	response	NN
cord-253295-82ydczid	297	20	to	to	IN
cord-253295-82ydczid	297	21	therapy	therapy	NN
cord-253295-82ydczid	297	22	.	.	.
cord-253295-82ydczid	298	1	Relational	relational	JJ
cord-253295-82ydczid	298	2	databases	database	NNS
cord-253295-82ydczid	298	3	which	which	WDT
cord-253295-82ydczid	298	4	correlate	correlate	VBP
cord-253295-82ydczid	298	5	an	an	DT
cord-253295-82ydczid	298	6	individual	individual	NN
cord-253295-82ydczid	298	7	's	's	POS
cord-253295-82ydczid	298	8	demographic	demographic	JJ
cord-253295-82ydczid	298	9	data	datum	NNS
cord-253295-82ydczid	298	10	,	,	,
cord-253295-82ydczid	298	11	family	family	NN
cord-253295-82ydczid	298	12	history	history	NN
cord-253295-82ydczid	298	13	,	,	,
cord-253295-82ydczid	298	14	and	and	CC
cord-253295-82ydczid	298	15	concurrent	concurrent	JJ
cord-253295-82ydczid	298	16	diseases	disease	NNS
cord-253295-82ydczid	298	17	with	with	IN
cord-253295-82ydczid	298	18	the	the	DT
cord-253295-82ydczid	298	19	neoplasm	neoplasm	NN
cord-253295-82ydczid	298	20	's	's	POS
cord-253295-82ydczid	298	21	morphologic	morphologic	JJ
cord-253295-82ydczid	298	22	features	feature	NNS
cord-253295-82ydczid	298	23	,	,	,
cord-253295-82ydczid	298	24	immunophenotype	immunophenotype	NN
cord-253295-82ydczid	298	25	,	,	,
cord-253295-82ydczid	298	26	and	and	CC
cord-253295-82ydczid	298	27	molecular	molecular	JJ
cord-253295-82ydczid	298	28	subset	subset	NN
cord-253295-82ydczid	298	29	,	,	,
cord-253295-82ydczid	298	30	and	and	CC
cord-253295-82ydczid	298	31	which	which	WDT
cord-253295-82ydczid	298	32	integrate	integrate	VBP
cord-253295-82ydczid	298	33	disease	disease	NN
cord-253295-82ydczid	298	34	prevalence	prevalence	NN
cord-253295-82ydczid	298	35	by	by	IN
cord-253295-82ydczid	298	36	age	age	NN
cord-253295-82ydczid	298	37	,	,	,
cord-253295-82ydczid	298	38	sex	sex	NN
cord-253295-82ydczid	298	39	,	,	,
cord-253295-82ydczid	298	40	and	and	CC
cord-253295-82ydczid	298	41	ethnicity	ethnicity	NN
cord-253295-82ydczid	298	42	using	use	VBG
cord-253295-82ydczid	298	43	Bayesian	bayesian	JJ
cord-253295-82ydczid	298	44	probabilities	probability	NNS
cord-253295-82ydczid	298	45	,	,	,
cord-253295-82ydczid	298	46	should	should	MD
cord-253295-82ydczid	298	47	improve	improve	VB
cord-253295-82ydczid	298	48	accuracy	accuracy	NN
cord-253295-82ydczid	298	49	of	of	IN
cord-253295-82ydczid	298	50	prognosis	prognosis	NN
cord-253295-82ydczid	298	51	and	and	CC
cord-253295-82ydczid	298	52	prediction	prediction	NN
cord-253295-82ydczid	298	53	of	of	IN
cord-253295-82ydczid	298	54	response	response	NN
cord-253295-82ydczid	298	55	to	to	IN
cord-253295-82ydczid	298	56	therapy	therapy	NN
cord-253295-82ydczid	298	57	.	.	.
cord-253295-82ydczid	299	1	As	as	IN
cord-253295-82ydczid	299	2	risk	risk	NN
cord-253295-82ydczid	299	3	correlates	correlate	VBZ
cord-253295-82ydczid	299	4	are	be	VBP
cord-253295-82ydczid	299	5	developed	develop	VBN
cord-253295-82ydczid	299	6	,	,	,
cord-253295-82ydczid	299	7	it	-PRON-	PRP
cord-253295-82ydczid	299	8	is	be	VBZ
cord-253295-82ydczid	299	9	possible	possible	JJ
cord-253295-82ydczid	299	10	that	that	IN
cord-253295-82ydczid	299	11	healthy	healthy	JJ
cord-253295-82ydczid	299	12	individuals	individual	NNS
cord-253295-82ydczid	299	13	can	can	MD
cord-253295-82ydczid	299	14	be	be	VB
cord-253295-82ydczid	299	15	screened	screen	VBN
cord-253295-82ydczid	299	16	and	and	CC
cord-253295-82ydczid	299	17	given	give	VBN
cord-253295-82ydczid	299	18	risk	risk	NN
cord-253295-82ydczid	299	19	estimates	estimate	NNS
cord-253295-82ydczid	299	20	for	for	IN
cord-253295-82ydczid	299	21	development	development	NN
cord-253295-82ydczid	299	22	of	of	IN
cord-253295-82ydczid	299	23	different	different	JJ
cord-253295-82ydczid	299	24	diseases	disease	NNS
cord-253295-82ydczid	299	25	,	,	,
cord-253295-82ydczid	299	26	as	as	IN
cord-253295-82ydczid	299	27	desired	desire	VBN
cord-253295-82ydczid	299	28	.	.	.
cord-253295-82ydczid	300	1	It	-PRON-	PRP
cord-253295-82ydczid	300	2	is	be	VBZ
cord-253295-82ydczid	300	3	worth	worth	JJ
cord-253295-82ydczid	300	4	noting	note	VBG
cord-253295-82ydczid	300	5	here	here	RB
cord-253295-82ydczid	300	6	that	that	IN
cord-253295-82ydczid	300	7	unaffected	unaffected	JJ
cord-253295-82ydczid	300	8	patients	patient	NNS
cord-253295-82ydczid	300	9	in	in	IN
cord-253295-82ydczid	300	10	inherited	inherit	VBN
cord-253295-82ydczid	300	11	-	-	HYPH
cord-253295-82ydczid	300	12	disease	disease	NN
cord-253295-82ydczid	300	13	kindreds	kindred	NNS
cord-253295-82ydczid	300	14	such	such	JJ
cord-253295-82ydczid	300	15	as	as	IN
cord-253295-82ydczid	300	16	Huntington	Huntington	NNP
cord-253295-82ydczid	300	17	's	's	POS
cord-253295-82ydczid	300	18	disease	disease	NN
cord-253295-82ydczid	300	19	may	may	MD
cord-253295-82ydczid	300	20	prefer	prefer	VB
cord-253295-82ydczid	300	21	not	not	RB
cord-253295-82ydczid	300	22	to	to	TO
cord-253295-82ydczid	300	23	know	know	VB
cord-253295-82ydczid	300	24	what	what	WP
cord-253295-82ydczid	300	25	the	the	DT
cord-253295-82ydczid	300	26	future	future	NN
cord-253295-82ydczid	300	27	holds	hold	VBZ
cord-253295-82ydczid	300	28	with	with	IN
cord-253295-82ydczid	300	29	respect	respect	NN
cord-253295-82ydczid	300	30	to	to	IN
cord-253295-82ydczid	300	31	the	the	DT
cord-253295-82ydczid	300	32	disease	disease	NN
cord-253295-82ydczid	300	33	that	that	WDT
cord-253295-82ydczid	300	34	runs	run	VBZ
cord-253295-82ydczid	300	35	in	in	IN
cord-253295-82ydczid	300	36	their	-PRON-	PRP$
cord-253295-82ydczid	300	37	extended	extended	JJ
cord-253295-82ydczid	300	38	family	family	NN
cord-253295-82ydczid	300	39	,	,	,
cord-253295-82ydczid	300	40	so	so	RB
cord-253295-82ydczid	300	41	germline	germline	JJ
cord-253295-82ydczid	300	42	screening	screening	NN
cord-253295-82ydczid	300	43	should	should	MD
cord-253295-82ydczid	300	44	hinge	hinge	VB
cord-253295-82ydczid	300	45	on	on	IN
cord-253295-82ydczid	300	46	pre	pre	JJ
cord-253295-82ydczid	300	47	test	test	NN
cord-253295-82ydczid	300	48	patient	patient	JJ
cord-253295-82ydczid	300	49	consent	consent	NN
cord-253295-82ydczid	300	50	.	.	.
cord-253295-82ydczid	301	1	Current	current	JJ
cord-253295-82ydczid	301	2	uses	use	NNS
cord-253295-82ydczid	301	3	of	of	IN
cord-253295-82ydczid	301	4	normal	normal	JJ
cord-253295-82ydczid	301	5	ranges	range	NNS
cord-253295-82ydczid	301	6	for	for	IN
cord-253295-82ydczid	301	7	serum	serum	NN
cord-253295-82ydczid	301	8	chemistry	chemistry	NN
cord-253295-82ydczid	301	9	assume	assume	VBP
cord-253295-82ydczid	301	10	similar	similar	JJ
cord-253295-82ydczid	301	11	bell	bell	NN
cord-253295-82ydczid	301	12	-	-	HYPH
cord-253295-82ydczid	301	13	curve	curve	NN
cord-253295-82ydczid	301	14	distributions	distribution	NNS
cord-253295-82ydczid	301	15	across	across	IN
cord-253295-82ydczid	301	16	ages	age	NNS
cord-253295-82ydczid	301	17	,	,	,
cord-253295-82ydczid	301	18	sexes	sex	NNS
cord-253295-82ydczid	301	19	,	,	,
cord-253295-82ydczid	301	20	and	and	CC
cord-253295-82ydczid	301	21	ethnicity	ethnicity	NN
cord-253295-82ydczid	301	22	.	.	.
cord-253295-82ydczid	302	1	This	this	DT
cord-253295-82ydczid	302	2	may	may	MD
cord-253295-82ydczid	302	3	not	not	RB
cord-253295-82ydczid	302	4	be	be	VB
cord-253295-82ydczid	302	5	true	true	JJ
cord-253295-82ydczid	302	6	for	for	IN
cord-253295-82ydczid	302	7	all	all	DT
cord-253295-82ydczid	302	8	analytes	analyte	NNS
cord-253295-82ydczid	302	9	,	,	,
cord-253295-82ydczid	302	10	so	so	RB
cord-253295-82ydczid	302	11	normal	normal	JJ
cord-253295-82ydczid	302	12	ranges	range	NNS
cord-253295-82ydczid	302	13	should	should	MD
cord-253295-82ydczid	302	14	be	be	VB
cord-253295-82ydczid	302	15	measured	measure	VBN
cord-253295-82ydczid	302	16	and	and	CC
cord-253295-82ydczid	302	17	compared	compare	VBN
cord-253295-82ydczid	302	18	,	,	,
cord-253295-82ydczid	302	19	with	with	IN
cord-253295-82ydczid	302	20	publication	publication	NN
cord-253295-82ydczid	302	21	of	of	IN
cord-253295-82ydczid	302	22	analytes	analyte	NNS
cord-253295-82ydczid	302	23	whose	whose	WP$
cord-253295-82ydczid	302	24	normal	normal	JJ
cord-253295-82ydczid	302	25	ranges	range	NNS
cord-253295-82ydczid	302	26	differ	differ	VBP
cord-253295-82ydczid	302	27	by	by	IN
cord-253295-82ydczid	302	28	age	age	NN
cord-253295-82ydczid	302	29	,	,	,
cord-253295-82ydczid	302	30	sex	sex	NN
cord-253295-82ydczid	302	31	,	,	,
cord-253295-82ydczid	302	32	or	or	CC
cord-253295-82ydczid	302	33	ethnic	ethnic	JJ
cord-253295-82ydczid	302	34	group	group	NN
cord-253295-82ydczid	302	35	.	.	.
cord-253295-82ydczid	303	1	Computer	computer	NN
cord-253295-82ydczid	303	2	reference	reference	NN
cord-253295-82ydczid	303	3	databases	database	NNS
cord-253295-82ydczid	303	4	facilitate	facilitate	VBP
cord-253295-82ydczid	303	5	this	this	DT
cord-253295-82ydczid	303	6	sort	sort	NN
cord-253295-82ydczid	303	7	of	of	IN
cord-253295-82ydczid	303	8	normal	normal	JJ
cord-253295-82ydczid	303	9	range	range	NN
cord-253295-82ydczid	303	10	database	database	NN
cord-253295-82ydczid	303	11	,	,	,
cord-253295-82ydczid	303	12	stratified	stratify	VBN
cord-253295-82ydczid	303	13	by	by	IN
cord-253295-82ydczid	303	14	age	age	NN
cord-253295-82ydczid	303	15	/	/	SYM
cord-253295-82ydczid	303	16	sex	sex	NN
cord-253295-82ydczid	303	17	/	/	SYM
cord-253295-82ydczid	303	18	ethnicity	ethnicity	NN
cord-253295-82ydczid	303	19	of	of	IN
cord-253295-82ydczid	303	20	individual	individual	JJ
cord-253295-82ydczid	303	21	patients	patient	NNS
cord-253295-82ydczid	303	22	.	.	.
cord-253295-82ydczid	304	1	Similarly	similarly	RB
cord-253295-82ydczid	304	2	,	,	,
cord-253295-82ydczid	304	3	familial	familial	JJ
cord-253295-82ydczid	304	4	risk	risk	NN
cord-253295-82ydczid	304	5	for	for	IN
cord-253295-82ydczid	304	6	an	an	DT
cord-253295-82ydczid	304	7	inherited	inherit	VBN
cord-253295-82ydczid	304	8	disease	disease	NN
cord-253295-82ydczid	304	9	may	may	MD
cord-253295-82ydczid	304	10	vary	vary	VB
cord-253295-82ydczid	304	11	by	by	IN
cord-253295-82ydczid	304	12	ethnic	ethnic	JJ
cord-253295-82ydczid	304	13	group	group	NN
cord-253295-82ydczid	304	14	,	,	,
cord-253295-82ydczid	304	15	and	and	CC
cord-253295-82ydczid	304	16	this	this	DT
cord-253295-82ydczid	304	17	variation	variation	NN
cord-253295-82ydczid	304	18	may	may	MD
cord-253295-82ydczid	304	19	be	be	VB
cord-253295-82ydczid	304	20	used	use	VBN
cord-253295-82ydczid	304	21	in	in	IN
cord-253295-82ydczid	304	22	Bayesian	bayesian	JJ
cord-253295-82ydczid	304	23	calculations	calculation	NNS
cord-253295-82ydczid	304	24	to	to	TO
cord-253295-82ydczid	304	25	define	define	VB
cord-253295-82ydczid	304	26	risk	risk	NN
cord-253295-82ydczid	304	27	for	for	IN
cord-253295-82ydczid	304	28	unaffected	unaffected	JJ
cord-253295-82ydczid	304	29	atrisk	atrisk	NNP
cord-253295-82ydczid	304	30	family	family	NN
cord-253295-82ydczid	304	31	members	member	NNS
cord-253295-82ydczid	304	32	.	.	.
cord-253295-82ydczid	305	1	Current	current	JJ
cord-253295-82ydczid	305	2	uses	use	NNS
cord-253295-82ydczid	305	3	of	of	IN
cord-253295-82ydczid	305	4	liver	liver	NN
cord-253295-82ydczid	305	5	and	and	CC
cord-253295-82ydczid	305	6	renal	renal	JJ
cord-253295-82ydczid	305	7	impairment	impairment	NN
cord-253295-82ydczid	305	8	to	to	TO
cord-253295-82ydczid	305	9	guide	guide	VB
cord-253295-82ydczid	305	10	drug	drug	NN
cord-253295-82ydczid	305	11	dosage	dosage	NN
cord-253295-82ydczid	305	12	demonstrate	demonstrate	VB
cord-253295-82ydczid	305	13	the	the	DT
cord-253295-82ydczid	305	14	benefit	benefit	NN
cord-253295-82ydczid	305	15	of	of	IN
cord-253295-82ydczid	305	16	using	use	VBG
cord-253295-82ydczid	305	17	patient	patient	JJ
cord-253295-82ydczid	305	18	physiology	physiology	NN
cord-253295-82ydczid	305	19	to	to	TO
cord-253295-82ydczid	305	20	customize	customize	VB
cord-253295-82ydczid	305	21	therapy	therapy	NN
cord-253295-82ydczid	305	22	.	.	.
cord-253295-82ydczid	306	1	We	-PRON-	PRP
cord-253295-82ydczid	306	2	are	be	VBP
cord-253295-82ydczid	306	3	now	now	RB
cord-253295-82ydczid	306	4	starting	start	VBG
cord-253295-82ydczid	306	5	to	to	TO
cord-253295-82ydczid	306	6	use	use	VB
cord-253295-82ydczid	306	7	gene	gene	NN
cord-253295-82ydczid	306	8	haplotype	haplotype	NN
cord-253295-82ydczid	306	9	data	datum	NNS
cord-253295-82ydczid	306	10	for	for	IN
cord-253295-82ydczid	306	11	specific	specific	JJ
cord-253295-82ydczid	306	12	genes	gene	NNS
cord-253295-82ydczid	306	13	that	that	WDT
cord-253295-82ydczid	306	14	encode	encode	VBP
cord-253295-82ydczid	306	15	specific	specific	JJ
cord-253295-82ydczid	306	16	drugmetabolizing	drugmetabolizing	NN
cord-253295-82ydczid	306	17	enzymes	enzyme	NNS
cord-253295-82ydczid	306	18	,	,	,
cord-253295-82ydczid	306	19	so	so	IN
cord-253295-82ydczid	306	20	as	as	IN
cord-253295-82ydczid	306	21	to	to	TO
cord-253295-82ydczid	306	22	guide	guide	VB
cord-253295-82ydczid	306	23	starting	start	VBG
cord-253295-82ydczid	306	24	doses	dose	NNS
cord-253295-82ydczid	306	25	for	for	IN
cord-253295-82ydczid	306	26	particular	particular	JJ
cord-253295-82ydczid	306	27	drugs	drug	NNS
cord-253295-82ydczid	306	28	(	(	-LRB-
cord-253295-82ydczid	307	1	e.g.	e.g.	RB
cord-253295-82ydczid	307	2	warfarin	warfarin	NN
cord-253295-82ydczid	307	3	,	,	,
cord-253295-82ydczid	307	4	tamoxifen	tamoxifen	NN
cord-253295-82ydczid	307	5	,	,	,
cord-253295-82ydczid	307	6	or	or	CC
cord-253295-82ydczid	307	7	clopidogrel/	clopidogrel/	CD
cord-253295-82ydczid	307	8	Plavix	Plavix	NNP
cord-253295-82ydczid	307	9	)	)	-RRB-
cord-253295-82ydczid	307	10	prior	prior	RB
cord-253295-82ydczid	307	11	to	to	IN
cord-253295-82ydczid	307	12	treatment	treatment	NN
cord-253295-82ydczid	307	13	initiation	initiation	NN
cord-253295-82ydczid	307	14	.	.	.
cord-253295-82ydczid	308	1	Current	current	JJ
cord-253295-82ydczid	308	2	uses	use	NNS
cord-253295-82ydczid	308	3	of	of	IN
cord-253295-82ydczid	308	4	prostate	prostate	NN
cord-253295-82ydczid	308	5	specific	specific	JJ
cord-253295-82ydczid	308	6	antigen	antigen	NN
cord-253295-82ydczid	308	7	(	(	-LRB-
cord-253295-82ydczid	308	8	PSA	PSA	NNP
cord-253295-82ydczid	308	9	)	)	-RRB-
cord-253295-82ydczid	308	10	to	to	TO
cord-253295-82ydczid	308	11	screen	screen	VB
cord-253295-82ydczid	308	12	for	for	IN
cord-253295-82ydczid	308	13	prostate	prostate	NN
cord-253295-82ydczid	308	14	carcinoma	carcinoma	NN
cord-253295-82ydczid	308	15	and	and	CC
cord-253295-82ydczid	308	16	its	-PRON-	PRP$
cord-253295-82ydczid	308	17	recurrence	recurrence	NN
cord-253295-82ydczid	308	18	demonstrate	demonstrate	VBP
cord-253295-82ydczid	308	19	the	the	DT
cord-253295-82ydczid	308	20	benefit	benefit	NN
cord-253295-82ydczid	308	21	of	of	IN
cord-253295-82ydczid	308	22	serum	serum	NN
cord-253295-82ydczid	308	23	biomarkers	biomarker	NNS
cord-253295-82ydczid	308	24	in	in	IN
cord-253295-82ydczid	308	25	common	common	JJ
cord-253295-82ydczid	308	26	neoplasms	neoplasm	NNS
cord-253295-82ydczid	308	27	.	.	.
cord-253295-82ydczid	309	1	It	-PRON-	PRP
cord-253295-82ydczid	309	2	is	be	VBZ
cord-253295-82ydczid	309	3	likely	likely	JJ
cord-253295-82ydczid	309	4	that	that	IN
cord-253295-82ydczid	309	5	high	high	JJ
cord-253295-82ydczid	309	6	-	-	HYPH
cord-253295-82ydczid	309	7	sensitivity	sensitivity	NN
cord-253295-82ydczid	309	8	screening	screening	NN
cord-253295-82ydczid	309	9	for	for	IN
cord-253295-82ydczid	309	10	single	single	JJ
cord-253295-82ydczid	309	11	and	and	CC
cord-253295-82ydczid	309	12	clustered	clustered	JJ
cord-253295-82ydczid	309	13	serum	serum	NN
cord-253295-82ydczid	309	14	analytes	analyte	NNS
cord-253295-82ydczid	309	15	using	use	VBG
cord-253295-82ydczid	309	16	proteomic	proteomic	JJ
cord-253295-82ydczid	309	17	and	and	CC
cord-253295-82ydczid	309	18	metabolomic	metabolomic	JJ
cord-253295-82ydczid	309	19	technologies	technology	NNS
cord-253295-82ydczid	309	20	will	will	MD
cord-253295-82ydczid	309	21	lead	lead	VB
cord-253295-82ydczid	309	22	to	to	IN
cord-253295-82ydczid	309	23	improved	improved	JJ
cord-253295-82ydczid	309	24	methods	method	NNS
cord-253295-82ydczid	309	25	for	for	IN
cord-253295-82ydczid	309	26	early	early	JJ
cord-253295-82ydczid	309	27	detection	detection	NN
cord-253295-82ydczid	309	28	of	of	IN
cord-253295-82ydczid	309	29	neoplasms	neoplasm	NNS
cord-253295-82ydczid	309	30	,	,	,
cord-253295-82ydczid	309	31	autoimmune	autoimmune	JJ
cord-253295-82ydczid	309	32	diseases	disease	NNS
cord-253295-82ydczid	309	33	,	,	,
cord-253295-82ydczid	309	34	and	and	CC
cord-253295-82ydczid	309	35	infections	infection	NNS
cord-253295-82ydczid	309	36	.	.	.
cord-253295-82ydczid	310	1	Residual	residual	JJ
cord-253295-82ydczid	310	2	disease	disease	NN
cord-253295-82ydczid	310	3	testing	testing	NN
cord-253295-82ydczid	310	4	for	for	IN
cord-253295-82ydczid	310	5	malignancies	malignancy	NNS
cord-253295-82ydczid	310	6	with	with	IN
cord-253295-82ydczid	310	7	clonal	clonal	JJ
cord-253295-82ydczid	310	8	mutations	mutation	NNS
cord-253295-82ydczid	310	9	or	or	CC
cord-253295-82ydczid	310	10	translocations	translocation	NNS
cord-253295-82ydczid	310	11	can	can	MD
cord-253295-82ydczid	310	12	now	now	RB
cord-253295-82ydczid	310	13	be	be	VB
cord-253295-82ydczid	310	14	performed	perform	VBN
cord-253295-82ydczid	310	15	via	via	IN
cord-253295-82ydczid	310	16	assays	assay	NNS
cord-253295-82ydczid	310	17	based	base	VBN
cord-253295-82ydczid	310	18	on	on	IN
cord-253295-82ydczid	310	19	circulating	circulate	VBG
cord-253295-82ydczid	310	20	tumor	tumor	NN
cord-253295-82ydczid	310	21	cells	cell	NNS
cord-253295-82ydczid	310	22	or	or	CC
cord-253295-82ydczid	310	23	circulating	circulate	VBG
cord-253295-82ydczid	310	24	cell	cell	NN
cord-253295-82ydczid	310	25	-	-	HYPH
cord-253295-82ydczid	310	26	free	free	JJ
cord-253295-82ydczid	310	27	tumor	tumor	NN
cord-253295-82ydczid	310	28	DNA	dna	NN
cord-253295-82ydczid	310	29	(	(	-LRB-
cord-253295-82ydczid	310	30	so	so	RB
cord-253295-82ydczid	310	31	-	-	HYPH
cord-253295-82ydczid	310	32	called	call	VBN
cord-253295-82ydczid	310	33	liquid	liquid	JJ
cord-253295-82ydczid	310	34	biopsies	biopsy	NNS
cord-253295-82ydczid	310	35	)	)	-RRB-
cord-253295-82ydczid	310	36	.	.	.
cord-253295-82ydczid	311	1	Similar	similar	JJ
cord-253295-82ydczid	311	2	high	high	JJ
cord-253295-82ydczid	311	3	-	-	HYPH
cord-253295-82ydczid	311	4	sensitivity	sensitivity	NN
cord-253295-82ydczid	311	5	testing	testing	NN
cord-253295-82ydczid	311	6	for	for	IN
cord-253295-82ydczid	311	7	disease	disease	NN
cord-253295-82ydczid	311	8	-	-	HYPH
cord-253295-82ydczid	311	9	specific	specific	JJ
cord-253295-82ydczid	311	10	analytes	analyte	NNS
cord-253295-82ydczid	311	11	may	may	MD
cord-253295-82ydczid	311	12	also	also	RB
cord-253295-82ydczid	311	13	improve	improve	VB
cord-253295-82ydczid	311	14	diagnosis	diagnosis	NN
cord-253295-82ydczid	311	15	,	,	,
cord-253295-82ydczid	311	16	treatment	treatment	NN
cord-253295-82ydczid	311	17	,	,	,
cord-253295-82ydczid	311	18	and	and	CC
cord-253295-82ydczid	311	19	residual	residual	JJ
cord-253295-82ydczid	311	20	disease	disease	NN
cord-253295-82ydczid	311	21	testing	testing	NN
cord-253295-82ydczid	311	22	for	for	IN
cord-253295-82ydczid	311	23	autoimmune	autoimmune	JJ
cord-253295-82ydczid	311	24	diseases	disease	NNS
cord-253295-82ydczid	311	25	,	,	,
cord-253295-82ydczid	311	26	and	and	CC
cord-253295-82ydczid	311	27	infections	infection	NNS
cord-253295-82ydczid	311	28	.	.	.
cord-253295-82ydczid	312	1	Treatment	treatment	NN
cord-253295-82ydczid	312	2	by	by	IN
cord-253295-82ydczid	312	3	pathway	pathway	NN
cord-253295-82ydczid	312	4	,	,	,
cord-253295-82ydczid	312	5	rather	rather	RB
cord-253295-82ydczid	312	6	than	than	IN
cord-253295-82ydczid	312	7	by	by	IN
cord-253295-82ydczid	312	8	tissue	tissue	NN
cord-253295-82ydczid	312	9	diagnosis	diagnosis	NN
cord-253295-82ydczid	313	1	Traditional	traditional	JJ
cord-253295-82ydczid	313	2	medical	medical	JJ
cord-253295-82ydczid	313	3	oncology	oncology	NN
cord-253295-82ydczid	313	4	chemotherapy	chemotherapy	NN
cord-253295-82ydczid	313	5	strategies	strategy	NNS
cord-253295-82ydczid	313	6	for	for	IN
cord-253295-82ydczid	313	7	malignant	malignant	JJ
cord-253295-82ydczid	313	8	neoplasms	neoplasm	NNS
cord-253295-82ydczid	313	9	hinged	hinge	VBN
cord-253295-82ydczid	313	10	on	on	IN
cord-253295-82ydczid	313	11	the	the	DT
cord-253295-82ydczid	313	12	tissue	tissue	NN
cord-253295-82ydczid	313	13	diagnosis	diagnosis	NN
cord-253295-82ydczid	313	14	and	and	CC
cord-253295-82ydczid	313	15	the	the	DT
cord-253295-82ydczid	313	16	organ	organ	NN
cord-253295-82ydczid	313	17	of	of	IN
cord-253295-82ydczid	313	18	origin	origin	NN
cord-253295-82ydczid	313	19	.	.	.
cord-253295-82ydczid	314	1	This	this	DT
cord-253295-82ydczid	314	2	is	be	VBZ
cord-253295-82ydczid	314	3	changing	change	VBG
cord-253295-82ydczid	314	4	,	,	,
cord-253295-82ydczid	314	5	as	as	IN
cord-253295-82ydczid	314	6	current	current	JJ
cord-253295-82ydczid	314	7	knowledge	knowledge	NN
cord-253295-82ydczid	314	8	of	of	IN
cord-253295-82ydczid	314	9	signaling	signal	VBG
cord-253295-82ydczid	314	10	pathway	pathway	NN
cord-253295-82ydczid	314	11	disruption	disruption	NN
cord-253295-82ydczid	314	12	by	by	IN
cord-253295-82ydczid	314	13	gain	gain	NN
cord-253295-82ydczid	314	14	-	-	HYPH
cord-253295-82ydczid	314	15	of	of	IN
cord-253295-82ydczid	314	16	-	-	HYPH
cord-253295-82ydczid	314	17	function	function	NN
cord-253295-82ydczid	314	18	mutations	mutation	NNS
cord-253295-82ydczid	314	19	,	,	,
cord-253295-82ydczid	314	20	e.g.	e.g.	RB
cord-253295-82ydczid	314	21	EGFR	EGFR	NNP
cord-253295-82ydczid	314	22	or	or	CC
cord-253295-82ydczid	314	23	BRAF	BRAF	NNP
cord-253295-82ydczid	314	24	,	,	,
cord-253295-82ydczid	314	25	points	point	VBZ
cord-253295-82ydczid	314	26	to	to	IN
cord-253295-82ydczid	314	27	specific	specific	JJ
cord-253295-82ydczid	314	28	treatment	treatment	NN
cord-253295-82ydczid	314	29	targets	target	NNS
cord-253295-82ydczid	314	30	.	.	.
cord-253295-82ydczid	315	1	The	the	DT
cord-253295-82ydczid	315	2	pharmaceutical	pharmaceutical	NN
cord-253295-82ydczid	315	3	industry	industry	NN
cord-253295-82ydczid	315	4	is	be	VBZ
cord-253295-82ydczid	315	5	able	able	JJ
cord-253295-82ydczid	315	6	to	to	TO
cord-253295-82ydczid	315	7	create	create	VB
cord-253295-82ydczid	315	8	small	small	JJ
cord-253295-82ydczid	315	9	-	-	HYPH
cord-253295-82ydczid	315	10	molecule	molecule	NN
cord-253295-82ydczid	315	11	inhibitors	inhibitor	NNS
cord-253295-82ydczid	315	12	and	and	CC
cord-253295-82ydczid	315	13	humanized	humanize	VBN
cord-253295-82ydczid	315	14	antibodies	antibody	NNS
cord-253295-82ydczid	315	15	that	that	WDT
cord-253295-82ydczid	315	16	allow	allow	VBP
cord-253295-82ydczid	315	17	specific	specific	JJ
cord-253295-82ydczid	315	18	treatment	treatment	NN
cord-253295-82ydczid	315	19	of	of	IN
cord-253295-82ydczid	315	20	specific	specific	JJ
cord-253295-82ydczid	315	21	mutant	mutant	JJ
cord-253295-82ydczid	315	22	enzyme	enzyme	NN
cord-253295-82ydczid	315	23	isoforms	isoform	NNS
cord-253295-82ydczid	315	24	.	.	.
cord-253295-82ydczid	316	1	Current	current	JJ
cord-253295-82ydczid	316	2	data	data	NN
cord-253295-82ydczid	316	3	suggests	suggest	VBZ
cord-253295-82ydczid	316	4	that	that	IN
cord-253295-82ydczid	316	5	many	many	JJ
cord-253295-82ydczid	316	6	,	,	,
cord-253295-82ydczid	316	7	if	if	IN
cord-253295-82ydczid	316	8	not	not	RB
cord-253295-82ydczid	316	9	most	most	JJS
cord-253295-82ydczid	316	10	,	,	,
cord-253295-82ydczid	316	11	patients	patient	NNS
cord-253295-82ydczid	316	12	with	with	IN
cord-253295-82ydczid	316	13	driver	driver	NN
cord-253295-82ydczid	316	14	gain	gain	NN
cord-253295-82ydczid	316	15	-	-	HYPH
cord-253295-82ydczid	316	16	of	of	IN
cord-253295-82ydczid	316	17	-	-	HYPH
cord-253295-82ydczid	316	18	function	function	NN
cord-253295-82ydczid	316	19	mutations	mutation	NNS
cord-253295-82ydczid	316	20	treated	treat	VBN
cord-253295-82ydczid	316	21	with	with	IN
cord-253295-82ydczid	316	22	specific	specific	JJ
cord-253295-82ydczid	316	23	inhibitors	inhibitor	NNS
cord-253295-82ydczid	316	24	will	will	MD
cord-253295-82ydczid	316	25	show	show	VB
cord-253295-82ydczid	316	26	an	an	DT
cord-253295-82ydczid	316	27	initial	initial	JJ
cord-253295-82ydczid	316	28	brisk	brisk	JJ
cord-253295-82ydczid	316	29	response	response	NN
cord-253295-82ydczid	316	30	,	,	,
cord-253295-82ydczid	316	31	although	although	IN
cord-253295-82ydczid	316	32	later	later	JJ
cord-253295-82ydczid	316	33	recurrence	recurrence	NN
cord-253295-82ydczid	316	34	is	be	VBZ
cord-253295-82ydczid	316	35	possible	possible	JJ
cord-253295-82ydczid	316	36	due	due	IN
cord-253295-82ydczid	316	37	to	to	IN
cord-253295-82ydczid	316	38	outgrowth	outgrowth	NN
cord-253295-82ydczid	316	39	of	of	IN
cord-253295-82ydczid	316	40	subclones	subclone	NNS
cord-253295-82ydczid	316	41	with	with	IN
cord-253295-82ydczid	316	42	different	different	JJ
cord-253295-82ydczid	316	43	driver	driver	NN
cord-253295-82ydczid	316	44	mutations	mutation	NNS
cord-253295-82ydczid	316	45	.	.	.
cord-253295-82ydczid	317	1	The	the	DT
cord-253295-82ydczid	317	2	challenge	challenge	NN
cord-253295-82ydczid	317	3	for	for	IN
cord-253295-82ydczid	317	4	the	the	DT
cord-253295-82ydczid	317	5	next	next	JJ
cord-253295-82ydczid	317	6	generation	generation	NN
cord-253295-82ydczid	317	7	of	of	IN
cord-253295-82ydczid	317	8	scientists	scientist	NNS
cord-253295-82ydczid	317	9	and	and	CC
cord-253295-82ydczid	317	10	oncologists	oncologist	NNS
cord-253295-82ydczid	317	11	is	be	VBZ
cord-253295-82ydczid	317	12	how	how	WRB
cord-253295-82ydczid	317	13	to	to	TO
cord-253295-82ydczid	317	14	rescue	rescue	VB
cord-253295-82ydczid	317	15	homozygous	homozygous	JJ
cord-253295-82ydczid	317	16	loss	loss	NN
cord-253295-82ydczid	317	17	-	-	HYPH
cord-253295-82ydczid	317	18	of	of	IN
cord-253295-82ydczid	317	19	-	-	HYPH
cord-253295-82ydczid	317	20	function	function	NN
cord-253295-82ydczid	317	21	mutations	mutation	NNS
cord-253295-82ydczid	317	22	that	that	WDT
cord-253295-82ydczid	317	23	are	be	VBP
cord-253295-82ydczid	317	24	etiologic	etiologic	JJ
cord-253295-82ydczid	317	25	in	in	IN
cord-253295-82ydczid	317	26	human	human	JJ
cord-253295-82ydczid	317	27	diseases	disease	NNS
cord-253295-82ydczid	317	28	,	,	,
cord-253295-82ydczid	317	29	e.g.	e.g.	RB
cord-253295-82ydczid	317	30	CFTR	CFTR	NNP
cord-253295-82ydczid	317	31	or	or	CC
cord-253295-82ydczid	317	32	P53	P53	NNP
cord-253295-82ydczid	317	33	.	.	.
cord-253295-82ydczid	318	1	Pathologists	pathologist	NNS
cord-253295-82ydczid	318	2	consider	consider	VBP
cord-253295-82ydczid	318	3	each	each	DT
cord-253295-82ydczid	318	4	disease	disease	NN
cord-253295-82ydczid	318	5	to	to	TO
cord-253295-82ydczid	318	6	have	have	VB
cord-253295-82ydczid	318	7	a	a	DT
cord-253295-82ydczid	318	8	natural	natural	JJ
cord-253295-82ydczid	318	9	,	,	,
cord-253295-82ydczid	318	10	mechanical	mechanical	JJ
cord-253295-82ydczid	318	11	,	,	,
cord-253295-82ydczid	318	12	physicochemical	physicochemical	JJ
cord-253295-82ydczid	318	13	basis	basis	NN
cord-253295-82ydczid	318	14	.	.	.
cord-253295-82ydczid	319	1	Each	each	DT
cord-253295-82ydczid	319	2	disease	disease	NN
cord-253295-82ydczid	319	3	has	have	VBZ
cord-253295-82ydczid	319	4	an	an	DT
cord-253295-82ydczid	319	5	etiology	etiology	NN
cord-253295-82ydczid	319	6	(	(	-LRB-
cord-253295-82ydczid	319	7	initial	initial	JJ
cord-253295-82ydczid	319	8	cause	cause	NN
cord-253295-82ydczid	319	9	)	)	-RRB-
cord-253295-82ydczid	319	10	,	,	,
cord-253295-82ydczid	319	11	a	a	DT
cord-253295-82ydczid	319	12	pathogenesis	pathogenesis	NN
cord-253295-82ydczid	319	13	(	(	-LRB-
cord-253295-82ydczid	319	14	stepwise	stepwise	JJ
cord-253295-82ydczid	319	15	progression	progression	NN
cord-253295-82ydczid	319	16	)	)	-RRB-
cord-253295-82ydczid	319	17	,	,	,
cord-253295-82ydczid	319	18	and	and	CC
cord-253295-82ydczid	319	19	a	a	DT
cord-253295-82ydczid	319	20	natural	natural	JJ
cord-253295-82ydczid	319	21	history	history	NN
cord-253295-82ydczid	319	22	with	with	IN
cord-253295-82ydczid	319	23	effects	effect	NNS
cord-253295-82ydczid	319	24	on	on	IN
cord-253295-82ydczid	319	25	normal	normal	JJ
cord-253295-82ydczid	319	26	function	function	NN
cord-253295-82ydczid	319	27	(	(	-LRB-
cord-253295-82ydczid	319	28	clinical	clinical	JJ
cord-253295-82ydczid	319	29	outcome	outcome	NN
cord-253295-82ydczid	319	30	)	)	-RRB-
cord-253295-82ydczid	319	31	.	.	.
cord-253295-82ydczid	320	1	Pathologists	pathologist	NNS
cord-253295-82ydczid	320	2	collect	collect	VBP
cord-253295-82ydczid	320	3	the	the	DT
cord-253295-82ydczid	320	4	data	datum	NNS
cord-253295-82ydczid	320	5	needed	need	VBN
cord-253295-82ydczid	320	6	to	to	TO
cord-253295-82ydczid	320	7	answer	answer	VB
cord-253295-82ydczid	320	8	patients	patient	NNS
cord-253295-82ydczid	320	9	'	'	POS
cord-253295-82ydczid	320	10	and	and	CC
cord-253295-82ydczid	320	11	clinicians	clinician	NNS
cord-253295-82ydczid	320	12	'	'	POS
cord-253295-82ydczid	320	13	questions	question	NNS
cord-253295-82ydczid	320	14	,	,	,
cord-253295-82ydczid	320	15	simply	simply	RB
cord-253295-82ydczid	320	16	phrased	phrase	VBN
cord-253295-82ydczid	320	17	as	as	IN
cord-253295-82ydczid	320	18	"	"	``
cord-253295-82ydczid	320	19	what	what	WP
cord-253295-82ydczid	320	20	is	be	VBZ
cord-253295-82ydczid	320	21	it	-PRON-	PRP
cord-253295-82ydczid	320	22	?	?	.
cord-253295-82ydczid	320	23	"	"	''
cord-253295-82ydczid	321	1	(	(	-LRB-
cord-253295-82ydczid	321	2	diagnosis	diagnosis	NN
cord-253295-82ydczid	321	3	)	)	-RRB-
cord-253295-82ydczid	321	4	,	,	,
cord-253295-82ydczid	321	5	"	"	``
cord-253295-82ydczid	321	6	how	how	WRB
cord-253295-82ydczid	321	7	it	-PRON-	PRP
cord-253295-82ydczid	321	8	going	go	VBG
cord-253295-82ydczid	321	9	to	to	TO
cord-253295-82ydczid	321	10	behave	behave	VB
cord-253295-82ydczid	321	11	?	?	.
cord-253295-82ydczid	321	12	"	"	''
cord-253295-82ydczid	322	1	(	(	-LRB-
cord-253295-82ydczid	322	2	prognosis	prognosis	NN
cord-253295-82ydczid	322	3	)	)	-RRB-
cord-253295-82ydczid	322	4	,	,	,
cord-253295-82ydczid	322	5	and	and	CC
cord-253295-82ydczid	322	6	"	"	``
cord-253295-82ydczid	322	7	how	how	WRB
cord-253295-82ydczid	322	8	do	do	VBP
cord-253295-82ydczid	322	9	I	-PRON-	PRP
cord-253295-82ydczid	322	10	treat	treat	VB
cord-253295-82ydczid	322	11	it	-PRON-	PRP
cord-253295-82ydczid	322	12	?	?	.
cord-253295-82ydczid	322	13	"	"	''
cord-253295-82ydczid	323	1	(	(	-LRB-
cord-253295-82ydczid	323	2	prediction	prediction	NN
cord-253295-82ydczid	323	3	of	of	IN
cord-253295-82ydczid	323	4	response	response	NN
cord-253295-82ydczid	323	5	to	to	IN
cord-253295-82ydczid	323	6	therapy	therapy	NN
cord-253295-82ydczid	323	7	)	)	-RRB-
cord-253295-82ydczid	323	8	.	.	.
cord-253295-82ydczid	324	1	Instincts	instinct	NNS
cord-253295-82ydczid	324	2	and	and	CC
cord-253295-82ydczid	324	3	diagnostic	diagnostic	JJ
cord-253295-82ydczid	324	4	criteria	criterion	NNS
cord-253295-82ydczid	324	5	,	,	,
cord-253295-82ydczid	324	6	as	as	RB
cord-253295-82ydczid	324	7	well	well	RB
cord-253295-82ydczid	324	8	as	as	IN
cord-253295-82ydczid	324	9	the	the	DT
cord-253295-82ydczid	324	10	optical	optical	JJ
cord-253295-82ydczid	324	11	,	,	,
cord-253295-82ydczid	324	12	mechanical	mechanical	JJ
cord-253295-82ydczid	324	13	,	,	,
cord-253295-82ydczid	324	14	chemical	chemical	NN
cord-253295-82ydczid	324	15	,	,	,
cord-253295-82ydczid	324	16	and	and	CC
cord-253295-82ydczid	324	17	computing	computing	NN
cord-253295-82ydczid	324	18	technologies	technology	NNS
cord-253295-82ydczid	324	19	described	describe	VBN
cord-253295-82ydczid	324	20	previously	previously	RB
cord-253295-82ydczid	324	21	,	,	,
cord-253295-82ydczid	324	22	are	be	VBP
cord-253295-82ydczid	324	23	the	the	DT
cord-253295-82ydczid	324	24	basis	basis	NN
cord-253295-82ydczid	324	25	for	for	IN
cord-253295-82ydczid	324	26	modern	modern	JJ
cord-253295-82ydczid	324	27	service	service	NN
cord-253295-82ydczid	324	28	pathology	pathology	NN
cord-253295-82ydczid	324	29	.	.	.
cord-253295-82ydczid	325	1	As	as	IN
cord-253295-82ydczid	325	2	the	the	DT
cord-253295-82ydczid	325	3	human	human	JJ
cord-253295-82ydczid	325	4	genome	genome	NN
cord-253295-82ydczid	325	5	is	be	VBZ
cord-253295-82ydczid	325	6	deciphered	decipher	VBN
cord-253295-82ydczid	325	7	,	,	,
cord-253295-82ydczid	325	8	and	and	CC
cord-253295-82ydczid	325	9	as	as	IN
cord-253295-82ydczid	325	10	the	the	DT
cord-253295-82ydczid	325	11	complex	complex	JJ
cord-253295-82ydczid	325	12	interactions	interaction	NNS
cord-253295-82ydczid	325	13	of	of	IN
cord-253295-82ydczid	325	14	cellular	cellular	JJ
cord-253295-82ydczid	325	15	biochemistry	biochemistry	NN
cord-253295-82ydczid	325	16	are	be	VBP
cord-253295-82ydczid	325	17	refined	refine	VBN
cord-253295-82ydczid	325	18	,	,	,
cord-253295-82ydczid	325	19	risk	risk	NN
cord-253295-82ydczid	325	20	of	of	IN
cord-253295-82ydczid	325	21	disease	disease	NN
cord-253295-82ydczid	325	22	in	in	IN
cord-253295-82ydczid	325	23	unaffected	unaffected	JJ
cord-253295-82ydczid	325	24	individuals	individual	NNS
cord-253295-82ydczid	325	25	will	will	MD
cord-253295-82ydczid	325	26	be	be	VB
cord-253295-82ydczid	325	27	calculable	calculable	JJ
cord-253295-82ydczid	325	28	,	,	,
cord-253295-82ydczid	325	29	disease	disease	NN
cord-253295-82ydczid	325	30	diagnosis	diagnosis	NN
cord-253295-82ydczid	325	31	will	will	MD
cord-253295-82ydczid	325	32	be	be	VB
cord-253295-82ydczid	325	33	increasingly	increasingly	RB
cord-253295-82ydczid	325	34	accurate	accurate	JJ
cord-253295-82ydczid	325	35	and	and	CC
cord-253295-82ydczid	325	36	prognostic	prognostic	JJ
cord-253295-82ydczid	325	37	,	,	,
cord-253295-82ydczid	325	38	and	and	CC
cord-253295-82ydczid	325	39	molecular	molecular	JJ
cord-253295-82ydczid	325	40	subsets	subset	NNS
cord-253295-82ydczid	325	41	of	of	IN
cord-253295-82ydczid	325	42	morphologically	morphologically	RB
cord-253295-82ydczid	325	43	defined	define	VBN
cord-253295-82ydczid	325	44	disease	disease	NN
cord-253295-82ydczid	325	45	entities	entity	NNS
cord-253295-82ydczid	325	46	will	will	MD
cord-253295-82ydczid	325	47	be	be	VB
cord-253295-82ydczid	325	48	used	use	VBN
cord-253295-82ydczid	325	49	to	to	TO
cord-253295-82ydczid	325	50	guide	guide	VB
cord-253295-82ydczid	325	51	customized	customize	VBN
cord-253295-82ydczid	325	52	therapy	therapy	NN
cord-253295-82ydczid	325	53	for	for	IN
cord-253295-82ydczid	325	54	individual	individual	JJ
cord-253295-82ydczid	325	55	patients	patient	NNS
cord-253295-82ydczid	325	56	.	.	.
cord-253295-82ydczid	326	1	It	-PRON-	PRP
cord-253295-82ydczid	326	2	is	be	VBZ
cord-253295-82ydczid	326	3	a	a	DT
cord-253295-82ydczid	326	4	great	great	JJ
cord-253295-82ydczid	326	5	time	time	NN
cord-253295-82ydczid	326	6	in	in	IN
cord-253295-82ydczid	326	7	history	history	NN
cord-253295-82ydczid	326	8	to	to	TO
cord-253295-82ydczid	326	9	be	be	VB
cord-253295-82ydczid	326	10	a	a	DT
cord-253295-82ydczid	326	11	pathologist	pathologist	NN
cord-253295-82ydczid	326	12	.	.	.
cord-253295-82ydczid	327	1	G	G	NNP
cord-253295-82ydczid	327	2	Clinically	clinically	RB
cord-253295-82ydczid	327	3	,	,	,
cord-253295-82ydczid	327	4	diseases	disease	NNS
cord-253295-82ydczid	327	5	present	present	JJ
cord-253295-82ydczid	327	6	to	to	IN
cord-253295-82ydczid	327	7	front	front	JJ
cord-253295-82ydczid	327	8	-	-	HYPH
cord-253295-82ydczid	327	9	line	line	NN
cord-253295-82ydczid	327	10	physicians	physician	NNS
cord-253295-82ydczid	327	11	as	as	IN
cord-253295-82ydczid	327	12	patients	patient	NNS
cord-253295-82ydczid	327	13	with	with	IN
cord-253295-82ydczid	327	14	sets	set	NNS
cord-253295-82ydczid	327	15	of	of	IN
cord-253295-82ydczid	327	16	signs	sign	NNS
cord-253295-82ydczid	327	17	and	and	CC
cord-253295-82ydczid	327	18	symptoms	symptom	NNS
cord-253295-82ydczid	327	19	.	.	.
cord-253295-82ydczid	328	1	Symptoms	symptom	NNS
cord-253295-82ydczid	328	2	are	be	VBP
cord-253295-82ydczid	328	3	the	the	DT
cord-253295-82ydczid	328	4	patient	patient	NN
cord-253295-82ydczid	328	5	's	's	POS
cord-253295-82ydczid	328	6	complaints	complaint	NNS
cord-253295-82ydczid	328	7	of	of	IN
cord-253295-82ydczid	328	8	perceived	perceive	VBN
cord-253295-82ydczid	328	9	abnormalities	abnormality	NNS
cord-253295-82ydczid	328	10	.	.	.
cord-253295-82ydczid	329	1	Signs	sign	NNS
cord-253295-82ydczid	329	2	are	be	VBP
cord-253295-82ydczid	329	3	detected	detect	VBN
cord-253295-82ydczid	329	4	by	by	IN
cord-253295-82ydczid	329	5	examination	examination	NN
cord-253295-82ydczid	329	6	of	of	IN
cord-253295-82ydczid	329	7	the	the	DT
cord-253295-82ydczid	329	8	patient	patient	NN
cord-253295-82ydczid	329	9	.	.	.
cord-253295-82ydczid	330	1	The	the	DT
cord-253295-82ydczid	330	2	clinical	clinical	JJ
cord-253295-82ydczid	330	3	team	team	NN
cord-253295-82ydczid	330	4	(	(	-LRB-
cord-253295-82ydczid	330	5	including	include	VBG
cord-253295-82ydczid	330	6	the	the	DT
cord-253295-82ydczid	330	7	pathologist	pathologist	NN
cord-253295-82ydczid	330	8	)	)	-RRB-
cord-253295-82ydczid	330	9	evaluate	evaluate	VB
cord-253295-82ydczid	330	10	the	the	DT
cord-253295-82ydczid	330	11	patient	patient	NN
cord-253295-82ydczid	330	12	based	base	VBN
cord-253295-82ydczid	330	13	on	on	IN
cord-253295-82ydczid	330	14	the	the	DT
cord-253295-82ydczid	330	15	possible	possible	JJ
cord-253295-82ydczid	330	16	causes	cause	NNS
cord-253295-82ydczid	330	17	of	of	IN
cord-253295-82ydczid	330	18	the	the	DT
cord-253295-82ydczid	330	19	signs	sign	NNS
cord-253295-82ydczid	330	20	and	and	CC
cord-253295-82ydczid	330	21	symptoms	symptom	NNS
cord-253295-82ydczid	330	22	(	(	-LRB-
cord-253295-82ydczid	330	23	the	the	DT
cord-253295-82ydczid	330	24	differential	differential	JJ
cord-253295-82ydczid	330	25	diagnosis	diagnosis	NN
cord-253295-82ydczid	330	26	)	)	-RRB-
cord-253295-82ydczid	330	27	.	.	.
cord-253295-82ydczid	331	1	G	g	NN
cord-253295-82ydczid	332	1	Pathologically	pathologically	RB
cord-253295-82ydczid	332	2	,	,	,
cord-253295-82ydczid	332	3	disease	disease	NN
cord-253295-82ydczid	332	4	is	be	VBZ
cord-253295-82ydczid	332	5	diagnosed	diagnose	VBN
cord-253295-82ydczid	332	6	by	by	IN
cord-253295-82ydczid	332	7	determining	determine	VBG
cord-253295-82ydczid	332	8	whether	whether	IN
cord-253295-82ydczid	332	9	the	the	DT
cord-253295-82ydczid	332	10	morphologic	morphologic	JJ
cord-253295-82ydczid	332	11	features	feature	NNS
cord-253295-82ydczid	332	12	match	match	VBP
cord-253295-82ydczid	332	13	the	the	DT
cord-253295-82ydczid	332	14	G	g	NN
cord-253295-82ydczid	332	15	set	set	NN
cord-253295-82ydczid	332	16	of	of	IN
cord-253295-82ydczid	332	17	diagnostic	diagnostic	JJ
cord-253295-82ydczid	332	18	criteria	criterion	NNS
cord-253295-82ydczid	332	19	previously	previously	RB
cord-253295-82ydczid	332	20	described	describe	VBN
cord-253295-82ydczid	332	21	for	for	IN
cord-253295-82ydczid	332	22	each	each	DT
cord-253295-82ydczid	332	23	disease	disease	NN
cord-253295-82ydczid	332	24	.	.	.
cord-253295-82ydczid	333	1	Pathologists	pathologist	NNS
cord-253295-82ydczid	333	2	diagnose	diagnose	VBP
cord-253295-82ydczid	333	3	disease	disease	NN
cord-253295-82ydczid	333	4	by	by	IN
cord-253295-82ydczid	333	5	generating	generate	VBG
cord-253295-82ydczid	333	6	a	a	DT
cord-253295-82ydczid	333	7	differential	differential	JJ
cord-253295-82ydczid	333	8	diagnosis	diagnosis	NN
cord-253295-82ydczid	333	9	,	,	,
cord-253295-82ydczid	333	10	then	then	RB
cord-253295-82ydczid	333	11	finding	find	VBG
cord-253295-82ydczid	333	12	the	the	DT
cord-253295-82ydczid	333	13	best	good	JJS
cord-253295-82ydczid	333	14	fit	fit	NN
cord-253295-82ydczid	333	15	for	for	IN
cord-253295-82ydczid	333	16	the	the	DT
cord-253295-82ydczid	333	17	clinical	clinical	JJ
cord-253295-82ydczid	333	18	presentation	presentation	NN
cord-253295-82ydczid	333	19	,	,	,
cord-253295-82ydczid	333	20	the	the	DT
cord-253295-82ydczid	333	21	radiographic	radiographic	JJ
cord-253295-82ydczid	333	22	appearance	appearance	NN
cord-253295-82ydczid	333	23	,	,	,
cord-253295-82ydczid	333	24	and	and	CC
cord-253295-82ydczid	333	25	the	the	DT
cord-253295-82ydczid	333	26	pathologic	pathologic	JJ
cord-253295-82ydczid	333	27	(	(	-LRB-
cord-253295-82ydczid	333	28	both	both	DT
cord-253295-82ydczid	333	29	clinical	clinical	JJ
cord-253295-82ydczid	333	30	lab	lab	NN
cord-253295-82ydczid	333	31	and	and	CC
cord-253295-82ydczid	333	32	morphologic	morphologic	JJ
cord-253295-82ydczid	333	33	)	)	-RRB-
cord-253295-82ydczid	333	34	findings	finding	NNS
cord-253295-82ydczid	333	35	.	.	.
cord-253295-82ydczid	334	1	G	G	NNP
cord-253295-82ydczid	334	2	Etiology	Etiology	NNP
cord-253295-82ydczid	334	3	describes	describe	VBZ
cord-253295-82ydczid	334	4	the	the	DT
cord-253295-82ydczid	334	5	causes	cause	NNS
cord-253295-82ydczid	334	6	of	of	IN
cord-253295-82ydczid	334	7	a	a	DT
cord-253295-82ydczid	334	8	disease	disease	NN
cord-253295-82ydczid	334	9	.	.	.
cord-253295-82ydczid	335	1	One	one	CD
cord-253295-82ydczid	335	2	disease	disease	NN
cord-253295-82ydczid	335	3	entity	entity	NN
cord-253295-82ydczid	335	4	can	can	MD
cord-253295-82ydczid	335	5	have	have	VB
cord-253295-82ydczid	335	6	more	more	JJR
cord-253295-82ydczid	335	7	than	than	IN
cord-253295-82ydczid	335	8	one	one	CD
cord-253295-82ydczid	335	9	etiology	etiology	NN
cord-253295-82ydczid	335	10	,	,	,
cord-253295-82ydczid	335	11	and	and	CC
cord-253295-82ydczid	335	12	a	a	DT
cord-253295-82ydczid	335	13	single	single	JJ
cord-253295-82ydczid	335	14	etiology	etiology	NN
cord-253295-82ydczid	335	15	can	can	MD
cord-253295-82ydczid	335	16	lead	lead	VB
cord-253295-82ydczid	335	17	to	to	IN
cord-253295-82ydczid	335	18	more	more	JJR
cord-253295-82ydczid	335	19	than	than	IN
cord-253295-82ydczid	335	20	one	one	CD
cord-253295-82ydczid	335	21	disease	disease	NN
cord-253295-82ydczid	335	22	.	.	.
cord-253295-82ydczid	336	1	For	for	IN
cord-253295-82ydczid	336	2	example	example	NN
cord-253295-82ydczid	336	3	,	,	,
cord-253295-82ydczid	336	4	emphysema	emphysema	NN
cord-253295-82ydczid	336	5	,	,	,
cord-253295-82ydczid	336	6	chronic	chronic	JJ
cord-253295-82ydczid	336	7	bronchitis	bronchitis	NN
cord-253295-82ydczid	336	8	,	,	,
cord-253295-82ydczid	336	9	and	and	CC
cord-253295-82ydczid	336	10	small	small	JJ
cord-253295-82ydczid	336	11	cell	cell	NN
cord-253295-82ydczid	336	12	lung	lung	NN
cord-253295-82ydczid	336	13	carcinoma	carcinoma	NN
cord-253295-82ydczid	336	14	can	can	MD
cord-253295-82ydczid	336	15	all	all	DT
cord-253295-82ydczid	336	16	occur	occur	VB
cord-253295-82ydczid	336	17	in	in	IN
cord-253295-82ydczid	336	18	long	long	JJ
cord-253295-82ydczid	336	19	-	-	HYPH
cord-253295-82ydczid	336	20	term	term	NN
cord-253295-82ydczid	336	21	smokers	smoker	NNS
cord-253295-82ydczid	336	22	(	(	-LRB-
cord-253295-82ydczid	336	23	different	different	JJ
cord-253295-82ydczid	336	24	diseases	disease	NNS
cord-253295-82ydczid	336	25	derived	derive	VBN
cord-253295-82ydczid	336	26	from	from	IN
cord-253295-82ydczid	336	27	a	a	DT
cord-253295-82ydczid	336	28	single	single	JJ
cord-253295-82ydczid	336	29	etiology	etiology	NN
cord-253295-82ydczid	336	30	)	)	-RRB-
cord-253295-82ydczid	336	31	.	.	.
cord-253295-82ydczid	337	1	Likewise	likewise	RB
cord-253295-82ydczid	337	2	,	,	,
cord-253295-82ydczid	337	3	the	the	DT
cord-253295-82ydczid	337	4	same	same	JJ
cord-253295-82ydczid	337	5	disease	disease	NN
cord-253295-82ydczid	337	6	(	(	-LRB-
cord-253295-82ydczid	337	7	for	for	IN
cord-253295-82ydczid	337	8	instance	instance	NN
cord-253295-82ydczid	337	9	,	,	,
cord-253295-82ydczid	337	10	emphysema	emphysema	NN
cord-253295-82ydczid	337	11	of	of	IN
cord-253295-82ydczid	337	12	the	the	DT
cord-253295-82ydczid	337	13	lung	lung	NN
cord-253295-82ydczid	337	14	)	)	-RRB-
cord-253295-82ydczid	337	15	can	can	MD
cord-253295-82ydczid	337	16	derive	derive	VB
cord-253295-82ydczid	337	17	from	from	IN
cord-253295-82ydczid	337	18	different	different	JJ
cord-253295-82ydczid	337	19	etiologies	etiology	NNS
cord-253295-82ydczid	337	20	(	(	-LRB-
cord-253295-82ydczid	337	21	emphysema	emphysema	NN
cord-253295-82ydczid	337	22	from	from	IN
cord-253295-82ydczid	337	23	a-1-antitrypsin	a-1-antitrypsin	PRP$
cord-253295-82ydczid	337	24	deficiency	deficiency	NN
cord-253295-82ydczid	337	25	or	or	CC
cord-253295-82ydczid	337	26	cigarette	cigarette	NN
cord-253295-82ydczid	337	27	smoke	smoke	NN
cord-253295-82ydczid	337	28	)	)	-RRB-
cord-253295-82ydczid	337	29	.	.	.
cord-253295-82ydczid	338	1	G	g	NN
cord-253295-82ydczid	339	1	The	the	DT
cord-253295-82ydczid	339	2	pathogenesis	pathogenesis	NN
cord-253295-82ydczid	339	3	of	of	IN
cord-253295-82ydczid	339	4	a	a	DT
cord-253295-82ydczid	339	5	disease	disease	NN
cord-253295-82ydczid	339	6	describes	describe	VBZ
cord-253295-82ydczid	339	7	its	-PRON-	PRP$
cord-253295-82ydczid	339	8	stepwise	stepwise	JJ
cord-253295-82ydczid	339	9	progression	progression	NN
cord-253295-82ydczid	339	10	after	after	IN
cord-253295-82ydczid	339	11	initiation	initiation	NN
cord-253295-82ydczid	339	12	in	in	IN
cord-253295-82ydczid	339	13	response	response	NN
cord-253295-82ydczid	339	14	to	to	IN
cord-253295-82ydczid	339	15	a	a	DT
cord-253295-82ydczid	339	16	specific	specific	JJ
cord-253295-82ydczid	339	17	etiologic	etiologic	JJ
cord-253295-82ydczid	339	18	factor	factor	NN
cord-253295-82ydczid	339	19	(	(	-LRB-
cord-253295-82ydczid	339	20	or	or	CC
cord-253295-82ydczid	339	21	factors	factor	NNS
cord-253295-82ydczid	339	22	)	)	-RRB-
cord-253295-82ydczid	339	23	.	.	.
cord-253295-82ydczid	340	1	Pathogenesis	Pathogenesis	NNP
cord-253295-82ydczid	340	2	can	can	MD
cord-253295-82ydczid	340	3	refer	refer	VB
cord-253295-82ydczid	340	4	to	to	IN
cord-253295-82ydczid	340	5	the	the	DT
cord-253295-82ydczid	340	6	changes	change	NNS
cord-253295-82ydczid	340	7	in	in	IN
cord-253295-82ydczid	340	8	the	the	DT
cord-253295-82ydczid	340	9	structure	structure	NN
cord-253295-82ydczid	340	10	or	or	CC
cord-253295-82ydczid	340	11	function	function	NN
cord-253295-82ydczid	340	12	of	of	IN
cord-253295-82ydczid	340	13	an	an	DT
cord-253295-82ydczid	340	14	organism	organism	NN
cord-253295-82ydczid	340	15	at	at	IN
cord-253295-82ydczid	340	16	the	the	DT
cord-253295-82ydczid	340	17	gross	gross	JJ
cord-253295-82ydczid	340	18	/	/	SYM
cord-253295-82ydczid	340	19	clinical	clinical	JJ
cord-253295-82ydczid	340	20	level	level	NN
cord-253295-82ydczid	340	21	,	,	,
cord-253295-82ydczid	340	22	and	and	CC
cord-253295-82ydczid	340	23	it	-PRON-	PRP
cord-253295-82ydczid	340	24	can	can	MD
cord-253295-82ydczid	340	25	refer	refer	VB
cord-253295-82ydczid	340	26	to	to	IN
cord-253295-82ydczid	340	27	the	the	DT
cord-253295-82ydczid	340	28	stepwise	stepwise	JJ
cord-253295-82ydczid	340	29	molecular	molecular	JJ
cord-253295-82ydczid	340	30	abnormalities	abnormality	NNS
cord-253295-82ydczid	340	31	leading	lead	VBG
cord-253295-82ydczid	340	32	to	to	IN
cord-253295-82ydczid	340	33	changes	change	NNS
cord-253295-82ydczid	340	34	in	in	IN
cord-253295-82ydczid	340	35	cellular	cellular	JJ
cord-253295-82ydczid	340	36	and	and	CC
cord-253295-82ydczid	340	37	tissue	tissue	NN
cord-253295-82ydczid	340	38	function	function	NN
cord-253295-82ydczid	340	39	.	.	.
cord-253295-82ydczid	341	1	G	g	NN
cord-253295-82ydczid	342	1	The	the	DT
cord-253295-82ydczid	342	2	natural	natural	JJ
cord-253295-82ydczid	342	3	history	history	NN
cord-253295-82ydczid	342	4	of	of	IN
cord-253295-82ydczid	342	5	a	a	DT
cord-253295-82ydczid	342	6	disease	disease	NN
cord-253295-82ydczid	342	7	describes	describe	VBZ
cord-253295-82ydczid	342	8	the	the	DT
cord-253295-82ydczid	342	9	expected	expect	VBN
cord-253295-82ydczid	342	10	course	course	NN
cord-253295-82ydczid	342	11	of	of	IN
cord-253295-82ydczid	342	12	disease	disease	NN
cord-253295-82ydczid	342	13	,	,	,
cord-253295-82ydczid	342	14	including	include	VBG
cord-253295-82ydczid	342	15	chronicity	chronicity	NN
cord-253295-82ydczid	342	16	,	,	,
cord-253295-82ydczid	342	17	functional	functional	JJ
cord-253295-82ydczid	342	18	impairment	impairment	NN
cord-253295-82ydczid	342	19	,	,	,
cord-253295-82ydczid	342	20	and	and	CC
cord-253295-82ydczid	342	21	survival	survival	NN
cord-253295-82ydczid	342	22	.	.	.
cord-253295-82ydczid	343	1	However	however	RB
cord-253295-82ydczid	343	2	,	,	,
cord-253295-82ydczid	343	3	not	not	RB
cord-253295-82ydczid	343	4	all	all	DT
cord-253295-82ydczid	343	5	patients	patient	NNS
cord-253295-82ydczid	343	6	with	with	IN
cord-253295-82ydczid	343	7	a	a	DT
cord-253295-82ydczid	343	8	given	give	VBN
cord-253295-82ydczid	343	9	disease	disease	NN
cord-253295-82ydczid	343	10	will	will	MD
cord-253295-82ydczid	343	11	naturally	naturally	RB
cord-253295-82ydczid	343	12	follow	follow	VB
cord-253295-82ydczid	343	13	the	the	DT
cord-253295-82ydczid	343	14	same	same	JJ
cord-253295-82ydczid	343	15	disease	disease	NN
cord-253295-82ydczid	343	16	course	course	NN
cord-253295-82ydczid	343	17	,	,	,
cord-253295-82ydczid	343	18	so	so	CC
cord-253295-82ydczid	343	19	differences	difference	NNS
cord-253295-82ydczid	343	20	in	in	IN
cord-253295-82ydczid	343	21	patient	patient	JJ
cord-253295-82ydczid	343	22	outcome	outcome	NN
cord-253295-82ydczid	343	23	do	do	VBP
cord-253295-82ydczid	343	24	not	not	RB
cord-253295-82ydczid	343	25	necessarily	necessarily	RB
cord-253295-82ydczid	343	26	correspond	correspond	VB
cord-253295-82ydczid	343	27	to	to	IN
cord-253295-82ydczid	343	28	incorrect	incorrect	JJ
cord-253295-82ydczid	343	29	diagnosis	diagnosis	NN
cord-253295-82ydczid	343	30	.	.	.
cord-253295-82ydczid	344	1	Variables	variable	NNS
cord-253295-82ydczid	344	2	that	that	WDT
cord-253295-82ydczid	344	3	independently	independently	RB
cord-253295-82ydczid	344	4	correlate	correlate	VBP
cord-253295-82ydczid	344	5	with	with	IN
cord-253295-82ydczid	344	6	clinical	clinical	JJ
cord-253295-82ydczid	344	7	outcome	outcome	NN
cord-253295-82ydczid	344	8	differences	difference	NNS
cord-253295-82ydczid	344	9	are	be	VBP
cord-253295-82ydczid	344	10	called	call	VBN
cord-253295-82ydczid	344	11	independent	independent	JJ
cord-253295-82ydczid	344	12	prognostic	prognostic	JJ
cord-253295-82ydczid	344	13	variables	variable	NNS
cord-253295-82ydczid	344	14	,	,	,
cord-253295-82ydczid	344	15	and	and	CC
cord-253295-82ydczid	344	16	are	be	VBP
cord-253295-82ydczid	344	17	assessed	assess	VBN
cord-253295-82ydczid	344	18	routinely	routinely	RB
cord-253295-82ydczid	344	19	in	in	IN
cord-253295-82ydczid	344	20	an	an	DT
cord-253295-82ydczid	344	21	effort	effort	NN
cord-253295-82ydczid	344	22	to	to	TO
cord-253295-82ydczid	344	23	predict	predict	VB
cord-253295-82ydczid	344	24	the	the	DT
cord-253295-82ydczid	344	25	natural	natural	JJ
cord-253295-82ydczid	344	26	history	history	NN
cord-253295-82ydczid	344	27	of	of	IN
cord-253295-82ydczid	344	28	the	the	DT
cord-253295-82ydczid	344	29	disease	disease	NN
cord-253295-82ydczid	344	30	in	in	IN
cord-253295-82ydczid	344	31	the	the	DT
cord-253295-82ydczid	344	32	patient	patient	NN
cord-253295-82ydczid	344	33	.	.	.
cord-253295-82ydczid	345	1	G	g	NN
cord-253295-82ydczid	345	2	Variables	variable	NNS
cord-253295-82ydczid	345	3	that	that	WDT
cord-253295-82ydczid	345	4	independently	independently	RB
cord-253295-82ydczid	345	5	correlate	correlate	VBP
cord-253295-82ydczid	345	6	with	with	IN
cord-253295-82ydczid	345	7	response	response	NN
cord-253295-82ydczid	345	8	to	to	IN
cord-253295-82ydczid	345	9	therapy	therapy	NN
cord-253295-82ydczid	345	10	are	be	VBP
cord-253295-82ydczid	345	11	called	call	VBN
cord-253295-82ydczid	345	12	independent	independent	JJ
cord-253295-82ydczid	345	13	predictive	predictive	JJ
cord-253295-82ydczid	345	14	variables	variable	NNS
cord-253295-82ydczid	345	15	,	,	,
cord-253295-82ydczid	345	16	and	and	CC
cord-253295-82ydczid	345	17	are	be	VBP
cord-253295-82ydczid	345	18	assessed	assess	VBN
cord-253295-82ydczid	345	19	routinely	routinely	RB
cord-253295-82ydczid	345	20	in	in	IN
cord-253295-82ydczid	345	21	an	an	DT
cord-253295-82ydczid	345	22	effort	effort	NN
cord-253295-82ydczid	345	23	to	to	TO
cord-253295-82ydczid	345	24	optimize	optimize	VB
cord-253295-82ydczid	345	25	therapeutic	therapeutic	JJ
cord-253295-82ydczid	345	26	response	response	NN
cord-253295-82ydczid	345	27	for	for	IN
cord-253295-82ydczid	345	28	each	each	DT
cord-253295-82ydczid	345	29	patient	patient	NN
cord-253295-82ydczid	345	30	.	.	.
cord-253295-82ydczid	346	1	Suggested	suggest	VBN
cord-253295-82ydczid	346	2	readings	reading	NNS
cord-253295-82ydczid	346	3	The	the	DT
cord-253295-82ydczid	346	4	greatest	great	JJS
cord-253295-82ydczid	346	5	benefit	benefit	NN
cord-253295-82ydczid	346	6	to	to	IN
cord-253295-82ydczid	346	7	mankind	mankind	NN
cord-253295-82ydczid	346	8	:	:	:
cord-253295-82ydczid	346	9	a	a	DT
cord-253295-82ydczid	346	10	medical	medical	JJ
cord-253295-82ydczid	346	11	history	history	NN
cord-253295-82ydczid	346	12	of	of	IN
cord-253295-82ydczid	346	13	humanity	humanity	NN
cord-253295-82ydczid	346	14	Unidentified	unidentified	JJ
cord-253295-82ydczid	346	15	curved	curved	JJ
cord-253295-82ydczid	346	16	bacilli	bacilli	NN
cord-253295-82ydczid	346	17	in	in	IN
cord-253295-82ydczid	346	18	the	the	DT
cord-253295-82ydczid	346	19	stomach	stomach	NN
cord-253295-82ydczid	346	20	of	of	IN
cord-253295-82ydczid	346	21	patients	patient	NNS
cord-253295-82ydczid	346	22	with	with	IN
cord-253295-82ydczid	346	23	gastritis	gastritis	NN
cord-253295-82ydczid	346	24	and	and	CC
cord-253295-82ydczid	346	25	peptic	peptic	JJ
cord-253295-82ydczid	346	26	ulceration	ulceration	NN
cord-253295-82ydczid	347	1	The	the	DT
cord-253295-82ydczid	347	2	legacy	legacy	NN
cord-253295-82ydczid	347	3	of	of	IN
cord-253295-82ydczid	347	4	Karl	Karl	NNP
cord-253295-82ydczid	347	5	Rokitansky	Rokitansky	NNP
cord-253295-82ydczid	347	6	Lectures	Lectures	NNP
cord-253295-82ydczid	347	7	on	on	IN
cord-253295-82ydczid	347	8	surgical	surgical	JJ
cord-253295-82ydczid	347	9	pathology	pathology	NN
cord-253295-82ydczid	347	10	.	.	.
cord-253295-82ydczid	348	1	London	London	NNP
cord-253295-82ydczid	348	2	:	:	:
cord-253295-82ydczid	348	3	Brown	Brown	NNP
cord-253295-82ydczid	348	4	,	,	,
cord-253295-82ydczid	348	5	Green	Green	NNP
cord-253295-82ydczid	348	6	,	,	,
cord-253295-82ydczid	348	7	and	and	CC
cord-253295-82ydczid	348	8	Longmans	Longmans	NNPS
cord-253295-82ydczid	348	9	Cellular	Cellular	NNP
cord-253295-82ydczid	348	10	pathology	pathology	NN
cord-253295-82ydczid	348	11	Investigations	investigation	NNS
cord-253295-82ydczid	348	12	concerning	concern	VBG
cord-253295-82ydczid	348	13	the	the	DT
cord-253295-82ydczid	348	14	etiology	etiology	NN
cord-253295-82ydczid	348	15	of	of	IN
cord-253295-82ydczid	348	16	leprosy	leprosy	NN
cord-253295-82ydczid	348	17	Die	Die	NNP
cord-253295-82ydczid	348	18	Ä	Ä	NNP
cord-253295-82ydczid	348	19	etiologie	etiologie	NN
cord-253295-82ydczid	348	20	der	der	NN
cord-253295-82ydczid	348	21	Tuberkulose	Tuberkulose	NNP
cord-253295-82ydczid	348	22	(	(	-LRB-
cord-253295-82ydczid	348	23	The	the	DT
cord-253295-82ydczid	348	24	etiology	etiology	NN
cord-253295-82ydczid	348	25	of	of	IN
cord-253295-82ydczid	348	26	tuberculosis	tuberculosis	NN
cord-253295-82ydczid	348	27	)	)	-RRB-
cord-253295-82ydczid	349	1	Rudolf	Rudolf	NNP
cord-253295-82ydczid	349	2	Virchow	Virchow	NNP
cord-253295-82ydczid	349	3	-	-	HYPH
cord-253295-82ydczid	349	4	father	father	NN
cord-253295-82ydczid	349	5	of	of	IN
cord-253295-82ydczid	349	6	cellular	cellular	JJ
cord-253295-82ydczid	349	7	pathology	pathology	NN
cord-253295-82ydczid	349	8	Contagiousness	Contagiousness	NNP
cord-253295-82ydczid	349	9	of	of	IN
cord-253295-82ydczid	349	10	puerperal	puerperal	JJ
cord-253295-82ydczid	349	11	fever	fever	NN
cord-253295-82ydczid	349	12	Oliver	Oliver	NNP
cord-253295-82ydczid	349	13	Wendell	Wendell	NNP
cord-253295-82ydczid	349	14	Holmes	Holmes	NNP
cord-253295-82ydczid	349	15	(	(	-LRB-
cord-253295-82ydczid	349	16	1809À1894	1809à1894	CD
cord-253295-82ydczid	349	17	)	)	-RRB-
cord-253295-82ydczid	349	18	and	and	CC
cord-253295-82ydczid	349	19	his	-PRON-	PRP$
cord-253295-82ydczid	349	20	essay	essay	NN
cord-253295-82ydczid	349	21	on	on	IN
cord-253295-82ydczid	349	22	puerperal	puerperal	JJ
cord-253295-82ydczid	349	23	fever	fever	NN
cord-253295-82ydczid	349	24	Ignac	Ignac	NNP
cord-253295-82ydczid	349	25	Semmelweis	Semmelweis	NNP
cord-253295-82ydczid	349	26	and	and	CC
cord-253295-82ydczid	349	27	the	the	DT
cord-253295-82ydczid	349	28	etiology	etiology	NN
cord-253295-82ydczid	349	29	of	of	IN
cord-253295-82ydczid	349	30	fetal	fetal	JJ
cord-253295-82ydczid	349	31	and	and	CC
cord-253295-82ydczid	349	32	neonatal	neonatal	JJ
cord-253295-82ydczid	349	33	sepsis	sepsis	NN
cord-253295-82ydczid	350	1	On	on	IN
cord-253295-82ydczid	350	2	the	the	DT
cord-253295-82ydczid	350	3	germ	germ	NN
cord-253295-82ydczid	350	4	theory	theory	NN
cord-253295-82ydczid	350	5	Ueber	Ueber	NNP
cord-253295-82ydczid	350	6	kunstliche	kunstliche	NNP
cord-253295-82ydczid	350	7	bildung	bildung	NNP
cord-253295-82ydczid	350	8	des	des	FW
cord-253295-82ydczid	350	9	harnstoffs	harnstoffs	NNP
cord-253295-82ydczid	351	1	In	in	IN
cord-253295-82ydczid	351	2	search	search	NN
cord-253295-82ydczid	351	3	of	of	IN
cord-253295-82ydczid	351	4	the	the	DT
cord-253295-82ydczid	351	5	origins	origin	NNS
cord-253295-82ydczid	351	6	of	of	IN
cord-253295-82ydczid	351	7	modern	modern	JJ
cord-253295-82ydczid	351	8	surgical	surgical	JJ
cord-253295-82ydczid	351	9	pathology	pathology	NN
cord-253295-82ydczid	352	1	The	the	DT
cord-253295-82ydczid	352	2	immunology	immunology	NN
cord-253295-82ydczid	352	3	of	of	IN
cord-253295-82ydczid	352	4	transplantation	transplantation	NN
cord-253295-82ydczid	353	1	An	an	DT
cord-253295-82ydczid	353	2	immunoglobulin	immunoglobulin	NN
cord-253295-82ydczid	353	3	heavy	heavy	JJ
cord-253295-82ydczid	353	4	chain	chain	NN
cord-253295-82ydczid	353	5	variable	variable	JJ
cord-253295-82ydczid	353	6	region	region	NN
cord-253295-82ydczid	353	7	gene	gene	NN
cord-253295-82ydczid	353	8	is	be	VBZ
cord-253295-82ydczid	353	9	generated	generate	VBN
cord-253295-82ydczid	353	10	from	from	IN
cord-253295-82ydczid	353	11	three	three	CD
cord-253295-82ydczid	353	12	segments	segment	NNS
cord-253295-82ydczid	353	13	of	of	IN
cord-253295-82ydczid	353	14	DNA	dna	NN
cord-253295-82ydczid	353	15	:	:	:
cord-253295-82ydczid	353	16	VH	VH	NNP
cord-253295-82ydczid	353	17	,	,	,
cord-253295-82ydczid	353	18	D	D	NNP
cord-253295-82ydczid	353	19	and	and	CC
cord-253295-82ydczid	353	20	JH	JH	NNP
cord-253295-82ydczid	353	21	Recombination	Recombination	NNP
cord-253295-82ydczid	353	22	events	event	NNS
cord-253295-82ydczid	353	23	that	that	WDT
cord-253295-82ydczid	353	24	activate	activate	VBP
cord-253295-82ydczid	353	25	,	,	,
cord-253295-82ydczid	353	26	diversify	diversify	VB
cord-253295-82ydczid	353	27	,	,	,
cord-253295-82ydczid	353	28	and	and	CC
cord-253295-82ydczid	353	29	delete	delete	VB
cord-253295-82ydczid	353	30	immunoglobulin	immunoglobulin	NN
cord-253295-82ydczid	353	31	genes	gene	NNS
cord-253295-82ydczid	353	32	Emerging	emerge	VBG
cord-253295-82ydczid	353	33	paradigms	paradigm	NNS
cord-253295-82ydczid	353	34	of	of	IN
cord-253295-82ydczid	353	35	T	t	NN
cord-253295-82ydczid	353	36	-	-	HYPH
cord-253295-82ydczid	353	37	cell	cell	NN
cord-253295-82ydczid	353	38	co	co	NN
cord-253295-82ydczid	353	39	-	-	JJ
cord-253295-82ydczid	353	40	stimulation	stimulation	NN
cord-253295-82ydczid	353	41	Localization	Localization	NNP
cord-253295-82ydczid	353	42	of	of	IN
cord-253295-82ydczid	353	43	antigen	antigen	NN
cord-253295-82ydczid	353	44	in	in	IN
cord-253295-82ydczid	353	45	tissue	tissue	NN
cord-253295-82ydczid	353	46	cells	cell	NNS
cord-253295-82ydczid	353	47	;	;	:
cord-253295-82ydczid	353	48	improvements	improvement	NNS
cord-253295-82ydczid	353	49	in	in	IN
cord-253295-82ydczid	353	50	a	a	DT
cord-253295-82ydczid	353	51	method	method	NN
cord-253295-82ydczid	353	52	for	for	IN
cord-253295-82ydczid	353	53	the	the	DT
cord-253295-82ydczid	353	54	detection	detection	NN
cord-253295-82ydczid	353	55	of	of	IN
cord-253295-82ydczid	353	56	antigen	antigen	NN
cord-253295-82ydczid	353	57	by	by	IN
cord-253295-82ydczid	353	58	means	mean	NNS
cord-253295-82ydczid	353	59	of	of	IN
cord-253295-82ydczid	353	60	fluorescent	fluorescent	JJ
cord-253295-82ydczid	353	61	antibody	antibody	NN
cord-253295-82ydczid	353	62	Continuous	continuous	JJ
cord-253295-82ydczid	353	63	cultures	culture	NNS
cord-253295-82ydczid	353	64	of	of	IN
cord-253295-82ydczid	353	65	fused	fuse	VBN
cord-253295-82ydczid	353	66	cells	cell	NNS
cord-253295-82ydczid	353	67	secreting	secrete	VBG
cord-253295-82ydczid	353	68	antibody	antibody	NN
cord-253295-82ydczid	353	69	of	of	IN
cord-253295-82ydczid	353	70	predefined	predefined	JJ
cord-253295-82ydczid	353	71	specificity	specificity	NN
cord-253295-82ydczid	353	72	Molecular	molecular	JJ
cord-253295-82ydczid	353	73	structure	structure	NN
cord-253295-82ydczid	353	74	of	of	IN
cord-253295-82ydczid	353	75	deoxypentose	deoxypentose	VBG
cord-253295-82ydczid	353	76	nucleic	nucleic	JJ
cord-253295-82ydczid	353	77	acids	acid	NNS
cord-253295-82ydczid	353	78	Molecular	molecular	JJ
cord-253295-82ydczid	353	79	configuration	configuration	NN
cord-253295-82ydczid	353	80	in	in	IN
cord-253295-82ydczid	353	81	sodium	sodium	NN
cord-253295-82ydczid	353	82	thymonucleate	thymonucleate	NN
cord-253295-82ydczid	353	83	Molecular	molecular	JJ
cord-253295-82ydczid	353	84	structure	structure	NN
cord-253295-82ydczid	353	85	of	of	IN
cord-253295-82ydczid	353	86	nucleic	nucleic	JJ
cord-253295-82ydczid	353	87	acids	acid	NNS
cord-253295-82ydczid	353	88	;	;	:
cord-253295-82ydczid	353	89	a	a	DT
cord-253295-82ydczid	353	90	structure	structure	NN
cord-253295-82ydczid	353	91	for	for	IN
cord-253295-82ydczid	353	92	deoxyribose	deoxyribose	JJ
cord-253295-82ydczid	353	93	nucleic	nucleic	JJ
cord-253295-82ydczid	353	94	acid	acid	NN
cord-253295-82ydczid	353	95	General	general	JJ
cord-253295-82ydczid	353	96	nature	nature	NN
cord-253295-82ydczid	353	97	of	of	IN
cord-253295-82ydczid	353	98	the	the	DT
cord-253295-82ydczid	353	99	genetic	genetic	JJ
cord-253295-82ydczid	353	100	code	code	NN
cord-253295-82ydczid	353	101	for	for	IN
cord-253295-82ydczid	353	102	proteins	protein	NNS
cord-253295-82ydczid	354	1	The	the	DT
cord-253295-82ydczid	354	2	RNA	RNA	NNP
cord-253295-82ydczid	354	3	code	code	NN
cord-253295-82ydczid	354	4	and	and	CC
cord-253295-82ydczid	354	5	protein	protein	NN
cord-253295-82ydczid	354	6	synthesis	synthesis	NN
cord-253295-82ydczid	354	7	Formation	formation	NN
cord-253295-82ydczid	354	8	and	and	CC
cord-253295-82ydczid	354	9	detection	detection	NN
cord-253295-82ydczid	354	10	of	of	IN
cord-253295-82ydczid	354	11	RNA	RNA	NNP
cord-253295-82ydczid	354	12	-	-	HYPH
cord-253295-82ydczid	354	13	DNA	dna	NN
cord-253295-82ydczid	354	14	hybrid	hybrid	NN
cord-253295-82ydczid	354	15	molecules	molecule	NNS
cord-253295-82ydczid	354	16	in	in	IN
cord-253295-82ydczid	354	17	cytological	cytological	JJ
cord-253295-82ydczid	354	18	preparations	preparation	NNS
cord-253295-82ydczid	354	19	Molecular	molecular	JJ
cord-253295-82ydczid	354	20	hybridization	hybridization	NN
cord-253295-82ydczid	354	21	of	of	IN
cord-253295-82ydczid	354	22	radioactive	radioactive	JJ
cord-253295-82ydczid	354	23	DNA	dna	NN
cord-253295-82ydczid	354	24	to	to	IN
cord-253295-82ydczid	354	25	the	the	DT
cord-253295-82ydczid	354	26	DNA	dna	NN
cord-253295-82ydczid	354	27	of	of	IN
cord-253295-82ydczid	354	28	cytological	cytological	JJ
cord-253295-82ydczid	354	29	preparations	preparation	NNS
cord-253295-82ydczid	354	30	Expression	Expression	NNP
cord-253295-82ydczid	354	31	in	in	IN
cord-253295-82ydczid	354	32	Escherichia	Escherichia	NNP
cord-253295-82ydczid	354	33	coli	coli	NNS
cord-253295-82ydczid	354	34	of	of	IN
cord-253295-82ydczid	354	35	chemically	chemically	RB
cord-253295-82ydczid	354	36	synthesized	synthesize	VBN
cord-253295-82ydczid	354	37	genes	gene	NNS
cord-253295-82ydczid	354	38	for	for	IN
cord-253295-82ydczid	354	39	human	human	JJ
cord-253295-82ydczid	354	40	insulin	insulin	NN
cord-253295-82ydczid	354	41	DNA	dna	NN
cord-253295-82ydczid	354	42	sequencing	sequencing	NN
cord-253295-82ydczid	354	43	with	with	IN
cord-253295-82ydczid	354	44	chain	chain	NN
cord-253295-82ydczid	354	45	-	-	HYPH
cord-253295-82ydczid	354	46	terminating	terminate	VBG
cord-253295-82ydczid	354	47	inhibitors	inhibitor	NNS
cord-253295-82ydczid	355	1	A	a	DT
cord-253295-82ydczid	355	2	new	new	JJ
cord-253295-82ydczid	355	3	method	method	NN
cord-253295-82ydczid	355	4	for	for	IN
cord-253295-82ydczid	355	5	sequencing	sequence	VBG
cord-253295-82ydczid	355	6	DNA	DNA	NNP
cord-253295-82ydczid	355	7	Fluorescence	Fluorescence	NNP
cord-253295-82ydczid	355	8	detection	detection	NN
cord-253295-82ydczid	355	9	in	in	IN
cord-253295-82ydczid	355	10	automated	automate	VBN
cord-253295-82ydczid	355	11	DNA	dna	NN
cord-253295-82ydczid	355	12	sequence	sequence	NN
cord-253295-82ydczid	355	13	analysis	analysis	NN
cord-253295-82ydczid	355	14	Initial	initial	JJ
cord-253295-82ydczid	355	15	sequencing	sequencing	NN
cord-253295-82ydczid	355	16	and	and	CC
cord-253295-82ydczid	355	17	analysis	analysis	NN
cord-253295-82ydczid	355	18	of	of	IN
cord-253295-82ydczid	355	19	the	the	DT
cord-253295-82ydczid	355	20	human	human	JJ
cord-253295-82ydczid	355	21	genome	genome	NN
cord-253295-82ydczid	356	1	The	the	DT
cord-253295-82ydczid	356	2	sequence	sequence	NN
cord-253295-82ydczid	356	3	of	of	IN
cord-253295-82ydczid	356	4	the	the	DT
cord-253295-82ydczid	356	5	human	human	JJ
cord-253295-82ydczid	356	6	genome	genome	NN
cord-253295-82ydczid	356	7	Specific	specific	JJ
cord-253295-82ydczid	356	8	enzymatic	enzymatic	JJ
cord-253295-82ydczid	356	9	amplification	amplification	NN
cord-253295-82ydczid	356	10	of	of	IN
cord-253295-82ydczid	356	11	DNA	dna	NN
cord-253295-82ydczid	356	12	in	in	IN
cord-253295-82ydczid	356	13	vitro	vitro	FW
cord-253295-82ydczid	356	14	:	:	:
cord-253295-82ydczid	356	15	the	the	DT
cord-253295-82ydczid	356	16	polymerase	polymerase	NN
cord-253295-82ydczid	356	17	chain	chain	NN
cord-253295-82ydczid	356	18	reaction	reaction	NN
cord-253295-82ydczid	356	19	Sternberg	Sternberg	NNP
cord-253295-82ydczid	356	20	's	's	POS
cord-253295-82ydczid	356	21	diagnostic	diagnostic	JJ
cord-253295-82ydczid	356	22	surgical	surgical	JJ
cord-253295-82ydczid	356	23	pathology	pathology	NN
cord-253295-82ydczid	356	24	.	.	.
cord-253295-82ydczid	357	1	Philadelphia	Philadelphia	NNP
cord-253295-82ydczid	357	2	:	:	:
cord-253295-82ydczid	358	1	Lippincott	Lippincott	NNP
cord-253295-82ydczid	358	2	Diagnostic	diagnostic	JJ
cord-253295-82ydczid	358	3	histopathology	histopathology	NN
cord-253295-82ydczid	358	4	of	of	IN
cord-253295-82ydczid	358	5	tumors	tumor	NNS
cord-253295-82ydczid	358	6	.	.	.
cord-253295-82ydczid	359	1	Churchill	Churchill	NNP
cord-253295-82ydczid	359	2	Livingstone	Livingstone	NNP
cord-253295-82ydczid	360	1	The	the	DT
cord-253295-82ydczid	360	2	continuing	continue	VBG
cord-253295-82ydczid	360	3	role	role	NN
cord-253295-82ydczid	360	4	of	of	IN
cord-253295-82ydczid	360	5	morphology	morphology	NN
cord-253295-82ydczid	360	6	in	in	IN
cord-253295-82ydczid	360	7	the	the	DT
cord-253295-82ydczid	360	8	molecular	molecular	JJ
cord-253295-82ydczid	360	9	age	age	NN