id sid tid token lemma pos cord-252871-qfrpuy3t 1 1 key key JJ cord-252871-qfrpuy3t 2 1 : : : cord-252871-qfrpuy3t 2 2 cord-252871-qfrpuy3 cord-252871-qfrpuy3 NNP cord-252871-qfrpuy3t 2 3 t t NNP cord-252871-qfrpuy3t 2 4 authors author NNS cord-252871-qfrpuy3t 2 5 : : : cord-252871-qfrpuy3t 2 6 Nasir Nasir NNP cord-252871-qfrpuy3t 2 7 , , , cord-252871-qfrpuy3t 2 8 Arshan Arshan NNP cord-252871-qfrpuy3t 2 9 ; ; : cord-252871-qfrpuy3t 2 10 Romero Romero NNP cord-252871-qfrpuy3t 2 11 - - HYPH cord-252871-qfrpuy3t 2 12 Severson Severson NNP cord-252871-qfrpuy3t 2 13 , , , cord-252871-qfrpuy3t 2 14 Ethan Ethan NNP cord-252871-qfrpuy3t 2 15 ; ; : cord-252871-qfrpuy3t 2 16 Claverie Claverie NNP cord-252871-qfrpuy3t 2 17 , , , cord-252871-qfrpuy3t 2 18 Jean Jean NNP cord-252871-qfrpuy3t 2 19 - - HYPH cord-252871-qfrpuy3t 2 20 Michel Michel NNP cord-252871-qfrpuy3t 2 21 title title NN cord-252871-qfrpuy3t 2 22 : : : cord-252871-qfrpuy3t 3 1 Investigating investigate VBG cord-252871-qfrpuy3t 3 2 the the DT cord-252871-qfrpuy3t 3 3 Concept Concept NNP cord-252871-qfrpuy3t 3 4 and and CC cord-252871-qfrpuy3t 3 5 Origin Origin NNP cord-252871-qfrpuy3t 3 6 of of IN cord-252871-qfrpuy3t 3 7 Viruses Viruses NNPS cord-252871-qfrpuy3t 3 8 date date NN cord-252871-qfrpuy3t 4 1 : : : cord-252871-qfrpuy3t 4 2 2020 2020 CD cord-252871-qfrpuy3t 4 3 - - HYPH cord-252871-qfrpuy3t 4 4 11 11 CD cord-252871-qfrpuy3t 4 5 - - HYPH cord-252871-qfrpuy3t 4 6 03 03 CD cord-252871-qfrpuy3t 4 7 journal journal NN cord-252871-qfrpuy3t 4 8 : : : cord-252871-qfrpuy3t 5 1 Trends trend NNS cord-252871-qfrpuy3t 6 1 Microbiol Microbiol NNP cord-252871-qfrpuy3t 6 2 DOI DOI NNP cord-252871-qfrpuy3t 6 3 : : : cord-252871-qfrpuy3t 7 1 10.1016 10.1016 CD cord-252871-qfrpuy3t 7 2 / / SYM cord-252871-qfrpuy3t 7 3 j.tim.2020.08.003 j.tim.2020.08.003 NNP cord-252871-qfrpuy3t 7 4 sha sha NNP cord-252871-qfrpuy3t 7 5 : : : cord-252871-qfrpuy3t 8 1 a5394c55c49c72b888165697a34864faf87c81c1 a5394c55c49c72b888165697a34864faf87c81c1 NNP cord-252871-qfrpuy3t 8 2 doc_id doc_id NNPS cord-252871-qfrpuy3t 8 3 : : : cord-252871-qfrpuy3t 8 4 252871 252871 CD cord-252871-qfrpuy3t 9 1 cord_uid cord_uid NN cord-252871-qfrpuy3t 9 2 : : : cord-252871-qfrpuy3t 10 1 qfrpuy3 qfrpuy3 NNP cord-252871-qfrpuy3t 10 2 t t NNP cord-252871-qfrpuy3t 11 1 The the DT cord-252871-qfrpuy3t 11 2 ongoing ongoing JJ cord-252871-qfrpuy3t 11 3 COVID-19 covid-19 JJ cord-252871-qfrpuy3t 11 4 pandemic pandemic NN cord-252871-qfrpuy3t 11 5 has have VBZ cord-252871-qfrpuy3t 11 6 piqued pique VBN cord-252871-qfrpuy3t 11 7 public public JJ cord-252871-qfrpuy3t 11 8 interest interest NN cord-252871-qfrpuy3t 11 9 in in IN cord-252871-qfrpuy3t 11 10 the the DT cord-252871-qfrpuy3t 11 11 properties property NNS cord-252871-qfrpuy3t 11 12 , , , cord-252871-qfrpuy3t 11 13 evolution evolution NN cord-252871-qfrpuy3t 11 14 , , , cord-252871-qfrpuy3t 11 15 and and CC cord-252871-qfrpuy3t 11 16 emergence emergence NN cord-252871-qfrpuy3t 11 17 of of IN cord-252871-qfrpuy3t 11 18 viruses virus NNS cord-252871-qfrpuy3t 11 19 . . . cord-252871-qfrpuy3t 12 1 Here here RB cord-252871-qfrpuy3t 12 2 , , , cord-252871-qfrpuy3t 12 3 we -PRON- PRP cord-252871-qfrpuy3t 12 4 discuss discuss VBP cord-252871-qfrpuy3t 12 5 how how WRB cord-252871-qfrpuy3t 12 6 these these DT cord-252871-qfrpuy3t 12 7 basic basic JJ cord-252871-qfrpuy3t 12 8 questions question NNS cord-252871-qfrpuy3t 12 9 have have VBP cord-252871-qfrpuy3t 12 10 surprisingly surprisingly RB cord-252871-qfrpuy3t 12 11 remained remain VBN cord-252871-qfrpuy3t 12 12 disputed dispute VBN cord-252871-qfrpuy3t 12 13 despite despite IN cord-252871-qfrpuy3t 12 14 being be VBG cord-252871-qfrpuy3t 12 15 increasingly increasingly RB cord-252871-qfrpuy3t 12 16 within within IN cord-252871-qfrpuy3t 12 17 the the DT cord-252871-qfrpuy3t 12 18 reach reach NN cord-252871-qfrpuy3t 12 19 of of IN cord-252871-qfrpuy3t 12 20 scientific scientific JJ cord-252871-qfrpuy3t 12 21 analysis analysis NN cord-252871-qfrpuy3t 12 22 . . . cord-252871-qfrpuy3t 13 1 We -PRON- PRP cord-252871-qfrpuy3t 13 2 review review VBP cord-252871-qfrpuy3t 13 3 recent recent JJ cord-252871-qfrpuy3t 13 4 data datum NNS cord-252871-qfrpuy3t 13 5 - - HYPH cord-252871-qfrpuy3t 13 6 driven drive VBN cord-252871-qfrpuy3t 13 7 efforts effort NNS cord-252871-qfrpuy3t 13 8 that that WDT cord-252871-qfrpuy3t 13 9 shed shed VBD cord-252871-qfrpuy3t 13 10 light light NN cord-252871-qfrpuy3t 13 11 into into IN cord-252871-qfrpuy3t 13 12 the the DT cord-252871-qfrpuy3t 13 13 origin origin NN cord-252871-qfrpuy3t 13 14 and and CC cord-252871-qfrpuy3t 13 15 evolution evolution NN cord-252871-qfrpuy3t 13 16 of of IN cord-252871-qfrpuy3t 13 17 viruses virus NNS cord-252871-qfrpuy3t 13 18 and and CC cord-252871-qfrpuy3t 13 19 explain explain VB cord-252871-qfrpuy3t 13 20 factors factor NNS cord-252871-qfrpuy3t 13 21 that that WDT cord-252871-qfrpuy3t 13 22 resist resist VBP cord-252871-qfrpuy3t 13 23 the the DT cord-252871-qfrpuy3t 13 24 widespread widespread JJ cord-252871-qfrpuy3t 13 25 acceptance acceptance NN cord-252871-qfrpuy3t 13 26 of of IN cord-252871-qfrpuy3t 13 27 new new JJ cord-252871-qfrpuy3t 13 28 views view NNS cord-252871-qfrpuy3t 13 29 and and CC cord-252871-qfrpuy3t 13 30 insights insight NNS cord-252871-qfrpuy3t 13 31 . . . cord-252871-qfrpuy3t 14 1 We -PRON- PRP cord-252871-qfrpuy3t 14 2 propose propose VBP cord-252871-qfrpuy3t 14 3 a a DT cord-252871-qfrpuy3t 14 4 new new JJ cord-252871-qfrpuy3t 14 5 definition definition NN cord-252871-qfrpuy3t 14 6 of of IN cord-252871-qfrpuy3t 14 7 viruses virus NNS cord-252871-qfrpuy3t 14 8 that that WDT cord-252871-qfrpuy3t 14 9 is be VBZ cord-252871-qfrpuy3t 14 10 not not RB cord-252871-qfrpuy3t 14 11 restricted restrict VBN cord-252871-qfrpuy3t 14 12 to to IN cord-252871-qfrpuy3t 14 13 the the DT cord-252871-qfrpuy3t 14 14 presence presence NN cord-252871-qfrpuy3t 14 15 or or CC cord-252871-qfrpuy3t 14 16 absence absence NN cord-252871-qfrpuy3t 14 17 of of IN cord-252871-qfrpuy3t 14 18 any any DT cord-252871-qfrpuy3t 14 19 genetic genetic JJ cord-252871-qfrpuy3t 14 20 or or CC cord-252871-qfrpuy3t 14 21 physical physical JJ cord-252871-qfrpuy3t 14 22 feature feature NN cord-252871-qfrpuy3t 14 23 , , , cord-252871-qfrpuy3t 14 24 detail detail VBP cord-252871-qfrpuy3t 14 25 a a DT cord-252871-qfrpuy3t 14 26 scenario scenario NN cord-252871-qfrpuy3t 14 27 for for IN cord-252871-qfrpuy3t 14 28 how how WRB cord-252871-qfrpuy3t 14 29 viruses virus NNS cord-252871-qfrpuy3t 14 30 likely likely RB cord-252871-qfrpuy3t 14 31 originated originate VBD cord-252871-qfrpuy3t 14 32 from from IN cord-252871-qfrpuy3t 14 33 ancient ancient JJ cord-252871-qfrpuy3t 14 34 cells cell NNS cord-252871-qfrpuy3t 14 35 , , , cord-252871-qfrpuy3t 14 36 and and CC cord-252871-qfrpuy3t 14 37 explain explain VB cord-252871-qfrpuy3t 14 38 technical technical JJ cord-252871-qfrpuy3t 14 39 and and CC cord-252871-qfrpuy3t 14 40 conceptual conceptual JJ cord-252871-qfrpuy3t 14 41 biases bias NNS cord-252871-qfrpuy3t 14 42 that that WDT cord-252871-qfrpuy3t 14 43 limit limit VBP cord-252871-qfrpuy3t 14 44 our -PRON- PRP$ cord-252871-qfrpuy3t 14 45 understanding understanding NN cord-252871-qfrpuy3t 14 46 of of IN cord-252871-qfrpuy3t 14 47 virus virus NN cord-252871-qfrpuy3t 14 48 evolution evolution NN cord-252871-qfrpuy3t 14 49 . . . cord-252871-qfrpuy3t 15 1 We -PRON- PRP cord-252871-qfrpuy3t 15 2 note note VBP cord-252871-qfrpuy3t 15 3 that that IN cord-252871-qfrpuy3t 15 4 the the DT cord-252871-qfrpuy3t 15 5 philosophical philosophical JJ cord-252871-qfrpuy3t 15 6 aspects aspect NNS cord-252871-qfrpuy3t 15 7 of of IN cord-252871-qfrpuy3t 15 8 virus virus NN cord-252871-qfrpuy3t 15 9 evolution evolution NN cord-252871-qfrpuy3t 15 10 also also RB cord-252871-qfrpuy3t 15 11 impact impact VBP cord-252871-qfrpuy3t 15 12 the the DT cord-252871-qfrpuy3t 15 13 way way NN cord-252871-qfrpuy3t 15 14 we -PRON- PRP cord-252871-qfrpuy3t 15 15 might may MD cord-252871-qfrpuy3t 15 16 prepare prepare VB cord-252871-qfrpuy3t 15 17 for for IN cord-252871-qfrpuy3t 15 18 future future JJ cord-252871-qfrpuy3t 15 19 outbreaks outbreak NNS cord-252871-qfrpuy3t 15 20 . . . cord-252871-qfrpuy3t 16 1 Arshan Arshan NNP cord-252871-qfrpuy3t 16 2 Nasir Nasir NNP cord-252871-qfrpuy3t 16 3 , , , cord-252871-qfrpuy3t 16 4 1 1 CD cord-252871-qfrpuy3t 16 5 , , , cord-252871-qfrpuy3t 16 6 * * NFP cord-252871-qfrpuy3t 16 7 Ethan Ethan NNP cord-252871-qfrpuy3t 16 8 Romero Romero NNP cord-252871-qfrpuy3t 16 9 - - HYPH cord-252871-qfrpuy3t 16 10 Severson Severson NNP cord-252871-qfrpuy3t 16 11 , , , cord-252871-qfrpuy3t 16 12 1 1 CD cord-252871-qfrpuy3t 16 13 and and CC cord-252871-qfrpuy3t 16 14 Jean Jean NNP cord-252871-qfrpuy3t 16 15 - - HYPH cord-252871-qfrpuy3t 16 16 Michel Michel NNP cord-252871-qfrpuy3t 16 17 Claverie Claverie NNP cord-252871-qfrpuy3t 16 18 2 2 CD cord-252871-qfrpuy3t 17 1 The the DT cord-252871-qfrpuy3t 17 2 ongoing ongoing JJ cord-252871-qfrpuy3t 17 3 COVID-19 covid-19 JJ cord-252871-qfrpuy3t 17 4 pandemic pandemic NN cord-252871-qfrpuy3t 17 5 has have VBZ cord-252871-qfrpuy3t 17 6 piqued pique VBN cord-252871-qfrpuy3t 17 7 public public JJ cord-252871-qfrpuy3t 17 8 interest interest NN cord-252871-qfrpuy3t 17 9 in in IN cord-252871-qfrpuy3t 17 10 the the DT cord-252871-qfrpuy3t 17 11 properties property NNS cord-252871-qfrpuy3t 17 12 , , , cord-252871-qfrpuy3t 17 13 evolution evolution NN cord-252871-qfrpuy3t 17 14 , , , cord-252871-qfrpuy3t 17 15 and and CC cord-252871-qfrpuy3t 17 16 emergence emergence NN cord-252871-qfrpuy3t 17 17 of of IN cord-252871-qfrpuy3t 17 18 viruses virus NNS cord-252871-qfrpuy3t 17 19 . . . cord-252871-qfrpuy3t 18 1 Here here RB cord-252871-qfrpuy3t 18 2 , , , cord-252871-qfrpuy3t 18 3 we -PRON- PRP cord-252871-qfrpuy3t 18 4 discuss discuss VBP cord-252871-qfrpuy3t 18 5 how how WRB cord-252871-qfrpuy3t 18 6 these these DT cord-252871-qfrpuy3t 18 7 basic basic JJ cord-252871-qfrpuy3t 18 8 questions question NNS cord-252871-qfrpuy3t 18 9 have have VBP cord-252871-qfrpuy3t 18 10 surprisingly surprisingly RB cord-252871-qfrpuy3t 18 11 remained remain VBN cord-252871-qfrpuy3t 18 12 disputed dispute VBN cord-252871-qfrpuy3t 18 13 despite despite IN cord-252871-qfrpuy3t 18 14 being be VBG cord-252871-qfrpuy3t 18 15 increasingly increasingly RB cord-252871-qfrpuy3t 18 16 within within IN cord-252871-qfrpuy3t 18 17 the the DT cord-252871-qfrpuy3t 18 18 reach reach NN cord-252871-qfrpuy3t 18 19 of of IN cord-252871-qfrpuy3t 18 20 scientific scientific JJ cord-252871-qfrpuy3t 18 21 analysis analysis NN cord-252871-qfrpuy3t 18 22 . . . cord-252871-qfrpuy3t 19 1 We -PRON- PRP cord-252871-qfrpuy3t 19 2 review review VBP cord-252871-qfrpuy3t 19 3 recent recent JJ cord-252871-qfrpuy3t 19 4 data datum NNS cord-252871-qfrpuy3t 19 5 - - HYPH cord-252871-qfrpuy3t 19 6 driven drive VBN cord-252871-qfrpuy3t 19 7 efforts effort NNS cord-252871-qfrpuy3t 19 8 that that WDT cord-252871-qfrpuy3t 19 9 shed shed VBD cord-252871-qfrpuy3t 19 10 light light NN cord-252871-qfrpuy3t 19 11 into into IN cord-252871-qfrpuy3t 19 12 the the DT cord-252871-qfrpuy3t 19 13 origin origin NN cord-252871-qfrpuy3t 19 14 and and CC cord-252871-qfrpuy3t 19 15 evolution evolution NN cord-252871-qfrpuy3t 19 16 of of IN cord-252871-qfrpuy3t 19 17 viruses virus NNS cord-252871-qfrpuy3t 19 18 and and CC cord-252871-qfrpuy3t 19 19 explain explain VB cord-252871-qfrpuy3t 19 20 factors factor NNS cord-252871-qfrpuy3t 19 21 that that WDT cord-252871-qfrpuy3t 19 22 resist resist VBP cord-252871-qfrpuy3t 19 23 the the DT cord-252871-qfrpuy3t 19 24 widespread widespread JJ cord-252871-qfrpuy3t 19 25 acceptance acceptance NN cord-252871-qfrpuy3t 19 26 of of IN cord-252871-qfrpuy3t 19 27 new new JJ cord-252871-qfrpuy3t 19 28 views view NNS cord-252871-qfrpuy3t 19 29 and and CC cord-252871-qfrpuy3t 19 30 insights insight NNS cord-252871-qfrpuy3t 19 31 . . . cord-252871-qfrpuy3t 20 1 We -PRON- PRP cord-252871-qfrpuy3t 20 2 propose propose VBP cord-252871-qfrpuy3t 20 3 a a DT cord-252871-qfrpuy3t 20 4 new new JJ cord-252871-qfrpuy3t 20 5 definition definition NN cord-252871-qfrpuy3t 20 6 of of IN cord-252871-qfrpuy3t 20 7 viruses virus NNS cord-252871-qfrpuy3t 20 8 that that WDT cord-252871-qfrpuy3t 20 9 is be VBZ cord-252871-qfrpuy3t 20 10 not not RB cord-252871-qfrpuy3t 20 11 restricted restrict VBN cord-252871-qfrpuy3t 20 12 to to IN cord-252871-qfrpuy3t 20 13 the the DT cord-252871-qfrpuy3t 20 14 presence presence NN cord-252871-qfrpuy3t 20 15 or or CC cord-252871-qfrpuy3t 20 16 absence absence NN cord-252871-qfrpuy3t 20 17 of of IN cord-252871-qfrpuy3t 20 18 any any DT cord-252871-qfrpuy3t 20 19 genetic genetic JJ cord-252871-qfrpuy3t 20 20 or or CC cord-252871-qfrpuy3t 20 21 physical physical JJ cord-252871-qfrpuy3t 20 22 feature feature NN cord-252871-qfrpuy3t 20 23 , , , cord-252871-qfrpuy3t 20 24 detail detail VBP cord-252871-qfrpuy3t 20 25 a a DT cord-252871-qfrpuy3t 20 26 scenario scenario NN cord-252871-qfrpuy3t 20 27 for for IN cord-252871-qfrpuy3t 20 28 how how WRB cord-252871-qfrpuy3t 20 29 viruses virus NNS cord-252871-qfrpuy3t 20 30 likely likely RB cord-252871-qfrpuy3t 20 31 originated originate VBD cord-252871-qfrpuy3t 20 32 from from IN cord-252871-qfrpuy3t 20 33 ancient ancient JJ cord-252871-qfrpuy3t 20 34 cells cell NNS cord-252871-qfrpuy3t 20 35 , , , cord-252871-qfrpuy3t 20 36 and and CC cord-252871-qfrpuy3t 20 37 explain explain VB cord-252871-qfrpuy3t 20 38 technical technical JJ cord-252871-qfrpuy3t 20 39 and and CC cord-252871-qfrpuy3t 20 40 conceptual conceptual JJ cord-252871-qfrpuy3t 20 41 biases bias NNS cord-252871-qfrpuy3t 20 42 that that WDT cord-252871-qfrpuy3t 20 43 limit limit VBP cord-252871-qfrpuy3t 20 44 our -PRON- PRP$ cord-252871-qfrpuy3t 20 45 understanding understanding NN cord-252871-qfrpuy3t 20 46 of of IN cord-252871-qfrpuy3t 20 47 virus virus NN cord-252871-qfrpuy3t 20 48 evolution evolution NN cord-252871-qfrpuy3t 20 49 . . . cord-252871-qfrpuy3t 21 1 We -PRON- PRP cord-252871-qfrpuy3t 21 2 note note VBP cord-252871-qfrpuy3t 21 3 that that IN cord-252871-qfrpuy3t 21 4 the the DT cord-252871-qfrpuy3t 21 5 philosophical philosophical JJ cord-252871-qfrpuy3t 21 6 aspects aspect NNS cord-252871-qfrpuy3t 21 7 of of IN cord-252871-qfrpuy3t 21 8 virus virus NN cord-252871-qfrpuy3t 21 9 evolution evolution NN cord-252871-qfrpuy3t 21 10 also also RB cord-252871-qfrpuy3t 21 11 impact impact VBP cord-252871-qfrpuy3t 21 12 the the DT cord-252871-qfrpuy3t 21 13 way way NN cord-252871-qfrpuy3t 21 14 we -PRON- PRP cord-252871-qfrpuy3t 21 15 might may MD cord-252871-qfrpuy3t 21 16 prepare prepare VB cord-252871-qfrpuy3t 21 17 for for IN cord-252871-qfrpuy3t 21 18 future future JJ cord-252871-qfrpuy3t 21 19 outbreaks outbreak NNS cord-252871-qfrpuy3t 21 20 . . . cord-252871-qfrpuy3t 22 1 The the DT cord-252871-qfrpuy3t 22 2 COVID-19 COVID-19 NNP cord-252871-qfrpuy3t 22 3 pandemic pandemic NN cord-252871-qfrpuy3t 22 4 exemplifies exemplify VBZ cord-252871-qfrpuy3t 22 5 the the DT cord-252871-qfrpuy3t 22 6 constant constant JJ cord-252871-qfrpuy3t 22 7 threat threat NN cord-252871-qfrpuy3t 22 8 and and CC cord-252871-qfrpuy3t 22 9 pressure pressure NN cord-252871-qfrpuy3t 22 10 exerted exert VBN cord-252871-qfrpuy3t 22 11 by by IN cord-252871-qfrpuy3t 22 12 viruses virus NNS cord-252871-qfrpuy3t 22 13 on on IN cord-252871-qfrpuy3t 22 14 human human JJ cord-252871-qfrpuy3t 22 15 health health NN cord-252871-qfrpuy3t 22 16 and and CC cord-252871-qfrpuy3t 22 17 the the DT cord-252871-qfrpuy3t 22 18 global global JJ cord-252871-qfrpuy3t 22 19 economy economy NN cord-252871-qfrpuy3t 22 20 . . . cord-252871-qfrpuy3t 23 1 The the DT cord-252871-qfrpuy3t 23 2 pandemic pandemic NN cord-252871-qfrpuy3t 23 3 has have VBZ cord-252871-qfrpuy3t 23 4 triggered trigger VBN cord-252871-qfrpuy3t 23 5 an an DT cord-252871-qfrpuy3t 23 6 aggressive aggressive JJ cord-252871-qfrpuy3t 23 7 international international JJ cord-252871-qfrpuy3t 23 8 response response NN cord-252871-qfrpuy3t 23 9 to to TO cord-252871-qfrpuy3t 23 10 contain contain VB cord-252871-qfrpuy3t 23 11 virus virus NN cord-252871-qfrpuy3t 23 12 spread spread VBN cord-252871-qfrpuy3t 23 13 , , , cord-252871-qfrpuy3t 23 14 cure cure VB cord-252871-qfrpuy3t 23 15 the the DT cord-252871-qfrpuy3t 23 16 disease disease NN cord-252871-qfrpuy3t 23 17 , , , cord-252871-qfrpuy3t 23 18 and and CC cord-252871-qfrpuy3t 23 19 prevent prevent VB cord-252871-qfrpuy3t 23 20 future future JJ cord-252871-qfrpuy3t 23 21 infections infection NNS cord-252871-qfrpuy3t 23 22 . . . cord-252871-qfrpuy3t 24 1 In in IN cord-252871-qfrpuy3t 24 2 parallel parallel NN cord-252871-qfrpuy3t 24 3 , , , cord-252871-qfrpuy3t 24 4 it -PRON- PRP cord-252871-qfrpuy3t 24 5 has have VBZ cord-252871-qfrpuy3t 24 6 rekindled rekindle VBN cord-252871-qfrpuy3t 24 7 public public JJ cord-252871-qfrpuy3t 24 8 curiosity curiosity NN cord-252871-qfrpuy3t 24 9 in in IN cord-252871-qfrpuy3t 24 10 virus virus NN cord-252871-qfrpuy3t 24 11 definitions definition NNS cord-252871-qfrpuy3t 24 12 , , , cord-252871-qfrpuy3t 24 13 origins origin NNS cord-252871-qfrpuy3t 24 14 , , , cord-252871-qfrpuy3t 24 15 evolution evolution NN cord-252871-qfrpuy3t 24 16 , , , cord-252871-qfrpuy3t 24 17 and and CC cord-252871-qfrpuy3t 24 18 their -PRON- PRP$ cord-252871-qfrpuy3t 24 19 various various JJ cord-252871-qfrpuy3t 24 20 modes mode NNS cord-252871-qfrpuy3t 24 21 of of IN cord-252871-qfrpuy3t 24 22 emergence emergence NN cord-252871-qfrpuy3t 24 23 . . . cord-252871-qfrpuy3t 25 1 For for IN cord-252871-qfrpuy3t 25 2 example example NN cord-252871-qfrpuy3t 25 3 , , , cord-252871-qfrpuy3t 25 4 Google Google NNP cord-252871-qfrpuy3t 25 5 search search NN cord-252871-qfrpuy3t 25 6 for for IN cord-252871-qfrpuy3t 25 7 ' ' '' cord-252871-qfrpuy3t 25 8 what what WP cord-252871-qfrpuy3t 25 9 is be VBZ cord-252871-qfrpuy3t 25 10 a a DT cord-252871-qfrpuy3t 25 11 virus virus NN cord-252871-qfrpuy3t 25 12 ' ' `` cord-252871-qfrpuy3t 25 13 reached reach VBN cord-252871-qfrpuy3t 25 14 peak peak NN cord-252871-qfrpuy3t 25 15 popularity popularity NN cord-252871-qfrpuy3t 25 16 in in IN cord-252871-qfrpuy3t 25 17 March March NNP cord-252871-qfrpuy3t 25 18 2020 2020 CD cord-252871-qfrpuy3t 25 19 coinciding coincide VBG cord-252871-qfrpuy3t 25 20 with with IN cord-252871-qfrpuy3t 25 21 the the DT cord-252871-qfrpuy3t 25 22 global global JJ cord-252871-qfrpuy3t 25 23 rise rise NN cord-252871-qfrpuy3t 25 24 in in IN cord-252871-qfrpuy3t 25 25 COVID-19 covid-19 JJ cord-252871-qfrpuy3t 25 26 cases case NNS cord-252871-qfrpuy3t 25 27 . . . cord-252871-qfrpuy3t 26 1 Surprisingly surprisingly RB cord-252871-qfrpuy3t 26 2 , , , cord-252871-qfrpuy3t 26 3 such such JJ cord-252871-qfrpuy3t 26 4 fundamental fundamental JJ cord-252871-qfrpuy3t 26 5 questions question NNS cord-252871-qfrpuy3t 26 6 have have VBP cord-252871-qfrpuy3t 26 7 remained remain VBN cord-252871-qfrpuy3t 26 8 unsettled unsettled JJ cord-252871-qfrpuy3t 26 9 even even RB cord-252871-qfrpuy3t 26 10 among among IN cord-252871-qfrpuy3t 26 11 evolutionary evolutionary JJ cord-252871-qfrpuy3t 26 12 virologists virologist NNS cord-252871-qfrpuy3t 26 13 [ [ -LRB- cord-252871-qfrpuy3t 26 14 1 1 CD cord-252871-qfrpuy3t 26 15 ] ] -RRB- cord-252871-qfrpuy3t 26 16 [ [ -LRB- cord-252871-qfrpuy3t 26 17 2 2 CD cord-252871-qfrpuy3t 26 18 ] ] -RRB- cord-252871-qfrpuy3t 26 19 [ [ -LRB- cord-252871-qfrpuy3t 26 20 3 3 CD cord-252871-qfrpuy3t 26 21 ] ] -RRB- cord-252871-qfrpuy3t 26 22 [ [ -LRB- cord-252871-qfrpuy3t 26 23 4 4 CD cord-252871-qfrpuy3t 26 24 ] ] -RRB- cord-252871-qfrpuy3t 26 25 [ [ -LRB- cord-252871-qfrpuy3t 26 26 5 5 CD cord-252871-qfrpuy3t 26 27 ] ] -RRB- cord-252871-qfrpuy3t 26 28 and and CC cord-252871-qfrpuy3t 26 29 cause cause VB cord-252871-qfrpuy3t 26 30 confusion confusion NN cord-252871-qfrpuy3t 26 31 in in IN cord-252871-qfrpuy3t 26 32 the the DT cord-252871-qfrpuy3t 26 33 media medium NNS cord-252871-qfrpuy3t 26 34 portrayal portrayal NN cord-252871-qfrpuy3t 26 35 and and CC cord-252871-qfrpuy3t 26 36 public public JJ cord-252871-qfrpuy3t 26 37 perception perception NN cord-252871-qfrpuy3t 26 38 . . . cord-252871-qfrpuy3t 27 1 For for IN cord-252871-qfrpuy3t 27 2 instance instance NN cord-252871-qfrpuy3t 27 3 , , , cord-252871-qfrpuy3t 27 4 despite despite IN cord-252871-qfrpuy3t 27 5 overwhelming overwhelming JJ cord-252871-qfrpuy3t 27 6 scientific scientific JJ cord-252871-qfrpuy3t 27 7 evidence evidence NN cord-252871-qfrpuy3t 27 8 supporting support VBG cord-252871-qfrpuy3t 27 9 a a DT cord-252871-qfrpuy3t 27 10 natural natural JJ cord-252871-qfrpuy3t 27 11 zoonotic zoonotic JJ cord-252871-qfrpuy3t 27 12 transmission transmission NN cord-252871-qfrpuy3t 27 13 of of IN cord-252871-qfrpuy3t 27 14 SARS SARS NNP cord-252871-qfrpuy3t 27 15 - - HYPH cord-252871-qfrpuy3t 27 16 CoV-2 CoV-2 NNP cord-252871-qfrpuy3t 27 17 from from IN cord-252871-qfrpuy3t 27 18 animals animal NNS cord-252871-qfrpuy3t 27 19 to to IN cord-252871-qfrpuy3t 27 20 humans human NNS cord-252871-qfrpuy3t 27 21 [ [ -LRB- cord-252871-qfrpuy3t 27 22 6 6 CD cord-252871-qfrpuy3t 27 23 ] ] -RRB- cord-252871-qfrpuy3t 27 24 , , , cord-252871-qfrpuy3t 27 25 many many JJ cord-252871-qfrpuy3t 27 26 still still RB cord-252871-qfrpuy3t 27 27 suspect suspect VBP cord-252871-qfrpuy3t 27 28 that that IN cord-252871-qfrpuy3t 27 29 the the DT cord-252871-qfrpuy3t 27 30 virus virus NN cord-252871-qfrpuy3t 27 31 was be VBD cord-252871-qfrpuy3t 27 32 purposefully purposefully RB cord-252871-qfrpuy3t 27 33 engineered engineer VBN cord-252871-qfrpuy3t 27 34 in in IN cord-252871-qfrpuy3t 27 35 laboratories laboratory NNS cord-252871-qfrpuy3t 27 36 . . . cord-252871-qfrpuy3t 28 1 Similarly similarly RB cord-252871-qfrpuy3t 28 2 , , , cord-252871-qfrpuy3t 28 3 viruses virus NNS cord-252871-qfrpuy3t 28 4 are be VBP cord-252871-qfrpuy3t 28 5 generalized generalize VBN cord-252871-qfrpuy3t 28 6 as as IN cord-252871-qfrpuy3t 28 7 noxious noxious JJ cord-252871-qfrpuy3t 28 8 pathogens pathogen NNS cord-252871-qfrpuy3t 28 9 in in IN cord-252871-qfrpuy3t 28 10 common common JJ cord-252871-qfrpuy3t 28 11 discussions discussion NNS cord-252871-qfrpuy3t 28 12 and and CC cord-252871-qfrpuy3t 28 13 this this DT cord-252871-qfrpuy3t 28 14 focus focus NN cord-252871-qfrpuy3t 28 15 greatly greatly RB cord-252871-qfrpuy3t 28 16 underestimates underestimate VBZ cord-252871-qfrpuy3t 28 17 the the DT cord-252871-qfrpuy3t 28 18 many many JJ cord-252871-qfrpuy3t 28 19 beneficial beneficial JJ cord-252871-qfrpuy3t 28 20 roles role NNS cord-252871-qfrpuy3t 28 21 they -PRON- PRP cord-252871-qfrpuy3t 28 22 play play VBP cord-252871-qfrpuy3t 28 23 in in IN cord-252871-qfrpuy3t 28 24 the the DT cord-252871-qfrpuy3t 28 25 biosphere biosphere NN cord-252871-qfrpuy3t 28 26 [ [ -LRB- cord-252871-qfrpuy3t 28 27 7 7 CD cord-252871-qfrpuy3t 28 28 , , , cord-252871-qfrpuy3t 28 29 8 8 CD cord-252871-qfrpuy3t 28 30 ] ] -RRB- cord-252871-qfrpuy3t 28 31 and and CC cord-252871-qfrpuy3t 28 32 as as IN cord-252871-qfrpuy3t 28 33 mutualistic mutualistic JJ cord-252871-qfrpuy3t 28 34 symbionts symbiont NNS cord-252871-qfrpuy3t 28 35 of of IN cord-252871-qfrpuy3t 28 36 many many JJ cord-252871-qfrpuy3t 28 37 hosts host NNS cord-252871-qfrpuy3t 28 38 ( ( -LRB- cord-252871-qfrpuy3t 28 39 reviewed review VBN cord-252871-qfrpuy3t 28 40 in in IN cord-252871-qfrpuy3t 28 41 [ [ -LRB- cord-252871-qfrpuy3t 28 42 9 9 CD cord-252871-qfrpuy3t 28 43 , , , cord-252871-qfrpuy3t 28 44 10 10 CD cord-252871-qfrpuy3t 28 45 ] ] -RRB- cord-252871-qfrpuy3t 28 46 ) ) -RRB- cord-252871-qfrpuy3t 28 47 . . . cord-252871-qfrpuy3t 29 1 In in IN cord-252871-qfrpuy3t 29 2 this this DT cord-252871-qfrpuy3t 29 3 article article NN cord-252871-qfrpuy3t 29 4 , , , cord-252871-qfrpuy3t 29 5 we -PRON- PRP cord-252871-qfrpuy3t 29 6 revisit revisit VBP cord-252871-qfrpuy3t 29 7 fundamental fundamental JJ cord-252871-qfrpuy3t 29 8 questions question NNS cord-252871-qfrpuy3t 29 9 about about IN cord-252871-qfrpuy3t 29 10 the the DT cord-252871-qfrpuy3t 29 11 nature nature NN cord-252871-qfrpuy3t 29 12 , , , cord-252871-qfrpuy3t 29 13 origins origin NNS cord-252871-qfrpuy3t 29 14 , , , cord-252871-qfrpuy3t 29 15 and and CC cord-252871-qfrpuy3t 29 16 evolution evolution NN cord-252871-qfrpuy3t 29 17 of of IN cord-252871-qfrpuy3t 29 18 viruses virus NNS cord-252871-qfrpuy3t 29 19 during during IN cord-252871-qfrpuy3t 29 20 a a DT cord-252871-qfrpuy3t 29 21 time time NN cord-252871-qfrpuy3t 29 22 when when WRB cord-252871-qfrpuy3t 29 23 public public JJ cord-252871-qfrpuy3t 29 24 interest interest NN cord-252871-qfrpuy3t 29 25 in in IN cord-252871-qfrpuy3t 29 26 virus virus NN cord-252871-qfrpuy3t 29 27 biology biology NN cord-252871-qfrpuy3t 29 28 is be VBZ cord-252871-qfrpuy3t 29 29 at at IN cord-252871-qfrpuy3t 29 30 its -PRON- PRP$ cord-252871-qfrpuy3t 29 31 peak peak NN cord-252871-qfrpuy3t 29 32 . . . cord-252871-qfrpuy3t 30 1 We -PRON- PRP cord-252871-qfrpuy3t 30 2 emphasize emphasize VBP cord-252871-qfrpuy3t 30 3 the the DT cord-252871-qfrpuy3t 30 4 need need NN cord-252871-qfrpuy3t 30 5 to to TO cord-252871-qfrpuy3t 30 6 rethink rethink VB cord-252871-qfrpuy3t 30 7 viruses virus NNS cord-252871-qfrpuy3t 30 8 in in IN cord-252871-qfrpuy3t 30 9 the the DT cord-252871-qfrpuy3t 30 10 light light NN cord-252871-qfrpuy3t 30 11 of of IN cord-252871-qfrpuy3t 30 12 new new JJ cord-252871-qfrpuy3t 30 13 discoveries discovery NNS cord-252871-qfrpuy3t 30 14 [ [ -LRB- cord-252871-qfrpuy3t 30 15 2 2 CD cord-252871-qfrpuy3t 30 16 ] ] -RRB- cord-252871-qfrpuy3t 30 17 and and CC cord-252871-qfrpuy3t 30 18 call call VB cord-252871-qfrpuy3t 30 19 for for IN cord-252871-qfrpuy3t 30 20 broader broad JJR cord-252871-qfrpuy3t 30 21 acceptance acceptance NN cord-252871-qfrpuy3t 30 22 of of IN cord-252871-qfrpuy3t 30 23 new new JJ cord-252871-qfrpuy3t 30 24 views view NNS cord-252871-qfrpuy3t 30 25 that that WDT cord-252871-qfrpuy3t 30 26 are be VBP cord-252871-qfrpuy3t 30 27 resisted resist VBN cord-252871-qfrpuy3t 30 28 by by IN cord-252871-qfrpuy3t 30 29 ( ( -LRB- cord-252871-qfrpuy3t 30 30 sometimes sometimes RB cord-252871-qfrpuy3t 30 31 ) ) -RRB- cord-252871-qfrpuy3t 30 32 century century NN cord-252871-qfrpuy3t 30 33 - - HYPH cord-252871-qfrpuy3t 30 34 old old JJ cord-252871-qfrpuy3t 30 35 concepts concept NNS cord-252871-qfrpuy3t 30 36 established establish VBN cord-252871-qfrpuy3t 30 37 in in IN cord-252871-qfrpuy3t 30 38 early early JJ cord-252871-qfrpuy3t 30 39 virology virology NN cord-252871-qfrpuy3t 30 40 research research NN cord-252871-qfrpuy3t 30 41 ( ( -LRB- cord-252871-qfrpuy3t 30 42 reviewed review VBN cord-252871-qfrpuy3t 30 43 in in IN cord-252871-qfrpuy3t 30 44 [ [ -LRB- cord-252871-qfrpuy3t 30 45 11 11 CD cord-252871-qfrpuy3t 30 46 ] ] -RRB- cord-252871-qfrpuy3t 30 47 ) ) -RRB- cord-252871-qfrpuy3t 30 48 . . . cord-252871-qfrpuy3t 31 1 Defining define VBG cord-252871-qfrpuy3t 31 2 viruses virus NNS cord-252871-qfrpuy3t 31 3 is be VBZ cord-252871-qfrpuy3t 31 4 surprisingly surprisingly RB cord-252871-qfrpuy3t 31 5 controversial controversial JJ cord-252871-qfrpuy3t 31 6 . . . cord-252871-qfrpuy3t 32 1 This this DT cord-252871-qfrpuy3t 32 2 is be VBZ cord-252871-qfrpuy3t 32 3 largely largely RB cord-252871-qfrpuy3t 32 4 because because IN cord-252871-qfrpuy3t 32 5 of of IN cord-252871-qfrpuy3t 32 6 the the DT cord-252871-qfrpuy3t 32 7 seemingly seemingly RB cord-252871-qfrpuy3t 32 8 split split VBN cord-252871-qfrpuy3t 32 9 nature nature NN cord-252871-qfrpuy3t 32 10 of of IN cord-252871-qfrpuy3t 32 11 the the DT cord-252871-qfrpuy3t 32 12 virus virus NN cord-252871-qfrpuy3t 32 13 reproduction reproduction NN cord-252871-qfrpuy3t 32 14 cycle cycle NN cord-252871-qfrpuy3t 32 15 into into IN cord-252871-qfrpuy3t 32 16 two two CD cord-252871-qfrpuy3t 32 17 distinct distinct JJ cord-252871-qfrpuy3t 32 18 stages stage NNS cord-252871-qfrpuy3t 32 19 : : : cord-252871-qfrpuy3t 32 20 ( ( -LRB- cord-252871-qfrpuy3t 32 21 i i NN cord-252871-qfrpuy3t 32 22 ) ) -RRB- cord-252871-qfrpuy3t 32 23 an an DT cord-252871-qfrpuy3t 32 24 intracellular intracellular JJ cord-252871-qfrpuy3t 32 25 stage stage NN cord-252871-qfrpuy3t 32 26 during during IN cord-252871-qfrpuy3t 32 27 which which WDT cord-252871-qfrpuy3t 32 28 the the DT cord-252871-qfrpuy3t 32 29 virus virus NN cord-252871-qfrpuy3t 32 30 reprograms reprogram VBZ cord-252871-qfrpuy3t 32 31 the the DT cord-252871-qfrpuy3t 32 32 infected infected JJ cord-252871-qfrpuy3t 32 33 cell cell NN cord-252871-qfrpuy3t 32 34 to to TO cord-252871-qfrpuy3t 32 35 produce produce VB cord-252871-qfrpuy3t 32 36 viral viral JJ cord-252871-qfrpuy3t 32 37 particles particle NNS cord-252871-qfrpuy3t 32 38 or or CC cord-252871-qfrpuy3t 32 39 virions virion NNS cord-252871-qfrpuy3t 32 40 ( ( -LRB- cord-252871-qfrpuy3t 32 41 see see VB cord-252871-qfrpuy3t 32 42 Glossary Glossary NNP cord-252871-qfrpuy3t 32 43 ) ) -RRB- cord-252871-qfrpuy3t 32 44 , , , cord-252871-qfrpuy3t 32 45 and and CC cord-252871-qfrpuy3t 32 46 ( ( -LRB- cord-252871-qfrpuy3t 32 47 ii ii NN cord-252871-qfrpuy3t 32 48 ) ) -RRB- cord-252871-qfrpuy3t 32 49 an an DT cord-252871-qfrpuy3t 32 50 extracellular extracellular JJ cord-252871-qfrpuy3t 32 51 stage stage NN cord-252871-qfrpuy3t 32 52 during during IN cord-252871-qfrpuy3t 32 53 which which WDT cord-252871-qfrpuy3t 32 54 virions virion NNS cord-252871-qfrpuy3t 32 55 escape escape VBP cord-252871-qfrpuy3t 32 56 the the DT cord-252871-qfrpuy3t 32 57 infected infected JJ cord-252871-qfrpuy3t 32 58 cells cell NNS cord-252871-qfrpuy3t 32 59 and and CC cord-252871-qfrpuy3t 32 60 persist persist VB cord-252871-qfrpuy3t 32 61 in in IN cord-252871-qfrpuy3t 32 62 the the DT cord-252871-qfrpuy3t 32 63 external external JJ cord-252871-qfrpuy3t 32 64 environment environment NN cord-252871-qfrpuy3t 32 65 ( ( -LRB- cord-252871-qfrpuy3t 32 66 similar similar JJ cord-252871-qfrpuy3t 32 67 to to TO cord-252871-qfrpuy3t 32 68 plant plant NN cord-252871-qfrpuy3t 32 69 seeds seed NNS cord-252871-qfrpuy3t 32 70 [ [ -LRB- cord-252871-qfrpuy3t 32 71 12 12 CD cord-252871-qfrpuy3t 32 72 ] ] -RRB- cord-252871-qfrpuy3t 32 73 ) ) -RRB- cord-252871-qfrpuy3t 32 74 . . . cord-252871-qfrpuy3t 33 1 1 1 LS cord-252871-qfrpuy3t 34 1 Both both DT cord-252871-qfrpuy3t 34 2 stages stage NNS cord-252871-qfrpuy3t 34 3 , , , cord-252871-qfrpuy3t 34 4 when when WRB cord-252871-qfrpuy3t 34 5 considered consider VBN cord-252871-qfrpuy3t 34 6 separately separately RB cord-252871-qfrpuy3t 34 7 , , , cord-252871-qfrpuy3t 34 8 provide provide VB cord-252871-qfrpuy3t 34 9 dramatically dramatically RB cord-252871-qfrpuy3t 34 10 contrasting contrast VBG cord-252871-qfrpuy3t 34 11 views view NNS cord-252871-qfrpuy3t 34 12 about about IN cord-252871-qfrpuy3t 34 13 the the DT cord-252871-qfrpuy3t 34 14 nature nature NN cord-252871-qfrpuy3t 34 15 and and CC cord-252871-qfrpuy3t 34 16 roles role NNS cord-252871-qfrpuy3t 34 17 of of IN cord-252871-qfrpuy3t 34 18 viruses virus NNS cord-252871-qfrpuy3t 34 19 . . . cord-252871-qfrpuy3t 35 1 For for IN cord-252871-qfrpuy3t 35 2 example example NN cord-252871-qfrpuy3t 35 3 , , , cord-252871-qfrpuy3t 35 4 virions virion NNS cord-252871-qfrpuy3t 35 5 are be VBP cord-252871-qfrpuy3t 35 6 metabolically metabolically RB cord-252871-qfrpuy3t 35 7 The the DT cord-252871-qfrpuy3t 35 8 distinctions distinction NNS cord-252871-qfrpuy3t 35 9 between between IN cord-252871-qfrpuy3t 35 10 virions virion NNS cord-252871-qfrpuy3t 35 11 and and CC cord-252871-qfrpuy3t 35 12 viruses virus NNS cord-252871-qfrpuy3t 35 13 and and CC cord-252871-qfrpuy3t 35 14 modern modern JJ cord-252871-qfrpuy3t 35 15 and and CC cord-252871-qfrpuy3t 35 16 ancient ancient JJ cord-252871-qfrpuy3t 35 17 cells cell NNS cord-252871-qfrpuy3t 35 18 are be VBP cord-252871-qfrpuy3t 35 19 crucial crucial JJ cord-252871-qfrpuy3t 35 20 to to TO cord-252871-qfrpuy3t 35 21 understand understand VB cord-252871-qfrpuy3t 35 22 virus virus NN cord-252871-qfrpuy3t 35 23 origins origin NNS cord-252871-qfrpuy3t 35 24 and and CC cord-252871-qfrpuy3t 35 25 evolution evolution NN cord-252871-qfrpuy3t 35 26 . . . cord-252871-qfrpuy3t 36 1 Viruses virus NNS cord-252871-qfrpuy3t 36 2 can can MD cord-252871-qfrpuy3t 36 3 be be VB cord-252871-qfrpuy3t 36 4 better well RBR cord-252871-qfrpuy3t 36 5 defined define VBN cord-252871-qfrpuy3t 36 6 by by IN cord-252871-qfrpuy3t 36 7 their -PRON- PRP$ cord-252871-qfrpuy3t 36 8 generic generic JJ cord-252871-qfrpuy3t 36 9 features feature NNS cord-252871-qfrpuy3t 36 10 of of IN cord-252871-qfrpuy3t 36 11 genome genome NN cord-252871-qfrpuy3t 36 12 propagation propagation NN cord-252871-qfrpuy3t 36 13 and and CC cord-252871-qfrpuy3t 36 14 dissemination dissemination NN cord-252871-qfrpuy3t 36 15 rather rather RB cord-252871-qfrpuy3t 36 16 than than IN cord-252871-qfrpuy3t 36 17 physical physical JJ cord-252871-qfrpuy3t 36 18 or or CC cord-252871-qfrpuy3t 36 19 biological biological JJ cord-252871-qfrpuy3t 36 20 properties property NNS cord-252871-qfrpuy3t 36 21 of of IN cord-252871-qfrpuy3t 36 22 their -PRON- PRP$ cord-252871-qfrpuy3t 36 23 virions virion NNS cord-252871-qfrpuy3t 36 24 or or CC cord-252871-qfrpuy3t 36 25 hosts host NNS cord-252871-qfrpuy3t 36 26 . . . cord-252871-qfrpuy3t 37 1 Virus virus NN cord-252871-qfrpuy3t 37 2 genomes genome NNS cord-252871-qfrpuy3t 37 3 are be VBP cord-252871-qfrpuy3t 37 4 characterized characterize VBN cord-252871-qfrpuy3t 37 5 by by IN cord-252871-qfrpuy3t 37 6 the the DT cord-252871-qfrpuy3t 37 7 abundance abundance NN cord-252871-qfrpuy3t 37 8 of of IN cord-252871-qfrpuy3t 37 9 virus virus NN cord-252871-qfrpuy3t 37 10 - - HYPH cord-252871-qfrpuy3t 37 11 specific specific JJ cord-252871-qfrpuy3t 37 12 genes gene NNS cord-252871-qfrpuy3t 37 13 that that WDT cord-252871-qfrpuy3t 37 14 lack lack VBP cord-252871-qfrpuy3t 37 15 detectable detectable JJ cord-252871-qfrpuy3t 37 16 cellular cellular JJ cord-252871-qfrpuy3t 37 17 homologs homolog NNS cord-252871-qfrpuy3t 37 18 . . . cord-252871-qfrpuy3t 38 1 Despite despite IN cord-252871-qfrpuy3t 38 2 their -PRON- PRP$ cord-252871-qfrpuy3t 38 3 abundance abundance NN cord-252871-qfrpuy3t 38 4 , , , cord-252871-qfrpuy3t 38 5 virus virus NN cord-252871-qfrpuy3t 38 6 - - HYPH cord-252871-qfrpuy3t 38 7 specific specific JJ cord-252871-qfrpuy3t 38 8 genes gene NNS cord-252871-qfrpuy3t 38 9 are be VBP cord-252871-qfrpuy3t 38 10 rarely rarely RB cord-252871-qfrpuy3t 38 11 discussed discuss VBN cord-252871-qfrpuy3t 38 12 in in IN cord-252871-qfrpuy3t 38 13 the the DT cord-252871-qfrpuy3t 38 14 models model NNS cord-252871-qfrpuy3t 38 15 of of IN cord-252871-qfrpuy3t 38 16 virus virus NN cord-252871-qfrpuy3t 38 17 origin origin NN cord-252871-qfrpuy3t 38 18 and and CC cord-252871-qfrpuy3t 38 19 evolution evolution NN cord-252871-qfrpuy3t 38 20 . . . cord-252871-qfrpuy3t 39 1 The the DT cord-252871-qfrpuy3t 39 2 alignment alignment NN cord-252871-qfrpuy3t 39 3 - - HYPH cord-252871-qfrpuy3t 39 4 based base VBN cord-252871-qfrpuy3t 39 5 methods method NNS cord-252871-qfrpuy3t 39 6 are be VBP cord-252871-qfrpuy3t 39 7 illsuited illsuite VBN cord-252871-qfrpuy3t 39 8 for for IN cord-252871-qfrpuy3t 39 9 the the DT cord-252871-qfrpuy3t 39 10 origins origin NNS cord-252871-qfrpuy3t 39 11 of of IN cord-252871-qfrpuy3t 39 12 life life NN cord-252871-qfrpuy3t 39 13 research research NN cord-252871-qfrpuy3t 39 14 , , , cord-252871-qfrpuy3t 39 15 especially especially RB cord-252871-qfrpuy3t 39 16 when when WRB cord-252871-qfrpuy3t 39 17 the the DT cord-252871-qfrpuy3t 39 18 objective objective NN cord-252871-qfrpuy3t 39 19 is be VBZ cord-252871-qfrpuy3t 39 20 to to TO cord-252871-qfrpuy3t 39 21 place place VB cord-252871-qfrpuy3t 39 22 fast fast RB cord-252871-qfrpuy3t 39 23 - - HYPH cord-252871-qfrpuy3t 39 24 evolving evolve VBG cord-252871-qfrpuy3t 39 25 organisms organism NNS cord-252871-qfrpuy3t 39 26 or or CC cord-252871-qfrpuy3t 39 27 viruses virus NNS cord-252871-qfrpuy3t 39 28 in in IN cord-252871-qfrpuy3t 39 29 the the DT cord-252871-qfrpuy3t 39 30 tree tree NN cord-252871-qfrpuy3t 39 31 of of IN cord-252871-qfrpuy3t 39 32 life life NN cord-252871-qfrpuy3t 39 33 . . . cord-252871-qfrpuy3t 40 1 Protein protein NN cord-252871-qfrpuy3t 40 2 structures structure NNS cord-252871-qfrpuy3t 40 3 may may MD cord-252871-qfrpuy3t 40 4 provide provide VB cord-252871-qfrpuy3t 40 5 a a DT cord-252871-qfrpuy3t 40 6 better well JJR cord-252871-qfrpuy3t 40 7 alternative alternative NN cord-252871-qfrpuy3t 40 8 to to TO cord-252871-qfrpuy3t 40 9 resolve resolve VB cord-252871-qfrpuy3t 40 10 the the DT cord-252871-qfrpuy3t 40 11 very very RB cord-252871-qfrpuy3t 40 12 deep deep JJ cord-252871-qfrpuy3t 40 13 branches branch NNS cord-252871-qfrpuy3t 40 14 in in IN cord-252871-qfrpuy3t 40 15 the the DT cord-252871-qfrpuy3t 40 16 tree tree NN cord-252871-qfrpuy3t 40 17 of of IN cord-252871-qfrpuy3t 40 18 life life NN cord-252871-qfrpuy3t 40 19 . . . cord-252871-qfrpuy3t 41 1 inert inert JJ cord-252871-qfrpuy3t 41 2 infectious infectious JJ cord-252871-qfrpuy3t 41 3 particles particle NNS cord-252871-qfrpuy3t 41 4 that that WDT cord-252871-qfrpuy3t 41 5 do do VBP cord-252871-qfrpuy3t 41 6 not not RB cord-252871-qfrpuy3t 41 7 meet meet VB cord-252871-qfrpuy3t 41 8 any any DT cord-252871-qfrpuy3t 41 9 of of IN cord-252871-qfrpuy3t 41 10 the the DT cord-252871-qfrpuy3t 41 11 criteria criterion NNS cord-252871-qfrpuy3t 41 12 we -PRON- PRP cord-252871-qfrpuy3t 41 13 may may MD cord-252871-qfrpuy3t 41 14 use use VB cord-252871-qfrpuy3t 41 15 to to TO cord-252871-qfrpuy3t 41 16 define define VB cord-252871-qfrpuy3t 41 17 ' ' `` cord-252871-qfrpuy3t 41 18 life life NN cord-252871-qfrpuy3t 41 19 ' ' '' cord-252871-qfrpuy3t 41 20 or or CC cord-252871-qfrpuy3t 41 21 living live VBG cord-252871-qfrpuy3t 41 22 organisms organism NNS cord-252871-qfrpuy3t 41 23 [ [ -LRB- cord-252871-qfrpuy3t 41 24 2 2 CD cord-252871-qfrpuy3t 41 25 ] ] -RRB- cord-252871-qfrpuy3t 41 26 . . . cord-252871-qfrpuy3t 42 1 However however RB cord-252871-qfrpuy3t 42 2 , , , cord-252871-qfrpuy3t 42 3 since since IN cord-252871-qfrpuy3t 42 4 they -PRON- PRP cord-252871-qfrpuy3t 42 5 can can MD cord-252871-qfrpuy3t 42 6 be be VB cord-252871-qfrpuy3t 42 7 purified purify VBN cord-252871-qfrpuy3t 42 8 , , , cord-252871-qfrpuy3t 42 9 counted count VBN cord-252871-qfrpuy3t 42 10 , , , cord-252871-qfrpuy3t 42 11 and and CC cord-252871-qfrpuy3t 42 12 visualized visualize VBN cord-252871-qfrpuy3t 42 13 under under IN cord-252871-qfrpuy3t 42 14 the the DT cord-252871-qfrpuy3t 42 15 microscope microscope NN cord-252871-qfrpuy3t 42 16 , , , cord-252871-qfrpuy3t 42 17 their -PRON- PRP$ cord-252871-qfrpuy3t 42 18 physical physical JJ cord-252871-qfrpuy3t 42 19 and and CC cord-252871-qfrpuy3t 42 20 biochemical biochemical JJ cord-252871-qfrpuy3t 42 21 properties property NNS cord-252871-qfrpuy3t 42 22 ( ( -LRB- cord-252871-qfrpuy3t 42 23 e.g. e.g. RB cord-252871-qfrpuy3t 42 24 , , , cord-252871-qfrpuy3t 42 25 size size NN cord-252871-qfrpuy3t 42 26 , , , cord-252871-qfrpuy3t 42 27 shape shape NN cord-252871-qfrpuy3t 42 28 , , , cord-252871-qfrpuy3t 42 29 metabolic metabolic JJ cord-252871-qfrpuy3t 42 30 capabilities capability NNS cord-252871-qfrpuy3t 42 31 , , , cord-252871-qfrpuy3t 42 32 capsid capsid NN cord-252871-qfrpuy3t 42 33 ) ) -RRB- cord-252871-qfrpuy3t 42 34 along along IN cord-252871-qfrpuy3t 42 35 with with IN cord-252871-qfrpuy3t 42 36 host host NN cord-252871-qfrpuy3t 42 37 / / SYM cord-252871-qfrpuy3t 42 38 tissue tissue NN cord-252871-qfrpuy3t 42 39 specificity specificity NN cord-252871-qfrpuy3t 42 40 have have VBP cord-252871-qfrpuy3t 42 41 become become VBN cord-252871-qfrpuy3t 42 42 popular popular JJ cord-252871-qfrpuy3t 42 43 in in IN cord-252871-qfrpuy3t 42 44 the the DT cord-252871-qfrpuy3t 42 45 description description NN cord-252871-qfrpuy3t 42 46 , , , cord-252871-qfrpuy3t 42 47 illustration illustration NN cord-252871-qfrpuy3t 42 48 , , , cord-252871-qfrpuy3t 42 49 and and CC cord-252871-qfrpuy3t 42 50 naming naming NN cord-252871-qfrpuy3t 42 51 of of IN cord-252871-qfrpuy3t 42 52 viruses virus NNS cord-252871-qfrpuy3t 42 53 ( ( -LRB- cord-252871-qfrpuy3t 42 54 e.g. e.g. RB cord-252871-qfrpuy3t 42 55 , , , cord-252871-qfrpuy3t 42 56 human human JJ cord-252871-qfrpuy3t 42 57 immunodeficiency immunodeficiency NN cord-252871-qfrpuy3t 42 58 virus virus NN cord-252871-qfrpuy3t 42 59 ) ) -RRB- cord-252871-qfrpuy3t 42 60 . . . cord-252871-qfrpuy3t 43 1 These these DT cord-252871-qfrpuy3t 43 2 , , , cord-252871-qfrpuy3t 43 3 in in IN cord-252871-qfrpuy3t 43 4 turn turn NN cord-252871-qfrpuy3t 43 5 , , , cord-252871-qfrpuy3t 43 6 have have VBP cord-252871-qfrpuy3t 43 7 shaped shape VBN cord-252871-qfrpuy3t 43 8 our -PRON- PRP$ cord-252871-qfrpuy3t 43 9 perceptions perception NNS cord-252871-qfrpuy3t 43 10 about about IN cord-252871-qfrpuy3t 43 11 viruses virus NNS cord-252871-qfrpuy3t 43 12 as as IN cord-252871-qfrpuy3t 43 13 nonliving nonlive VBG cord-252871-qfrpuy3t 43 14 inanimate inanimate JJ cord-252871-qfrpuy3t 43 15 biological biological JJ cord-252871-qfrpuy3t 43 16 objects object NNS cord-252871-qfrpuy3t 43 17 that that WDT cord-252871-qfrpuy3t 43 18 are be VBP cord-252871-qfrpuy3t 43 19 , , , cord-252871-qfrpuy3t 43 20 paradoxically paradoxically RB cord-252871-qfrpuy3t 43 21 , , , cord-252871-qfrpuy3t 43 22 infectious infectious JJ cord-252871-qfrpuy3t 43 23 . . . cord-252871-qfrpuy3t 44 1 Treating treat VBG cord-252871-qfrpuy3t 44 2 virions virion NNS cord-252871-qfrpuy3t 44 3 as as IN cord-252871-qfrpuy3t 44 4 viruses virus NNS cord-252871-qfrpuy3t 44 5 is be VBZ cord-252871-qfrpuy3t 44 6 a a DT cord-252871-qfrpuy3t 44 7 conceptual conceptual JJ cord-252871-qfrpuy3t 44 8 mistake mistake NN cord-252871-qfrpuy3t 44 9 [ [ -LRB- cord-252871-qfrpuy3t 44 10 2 2 CD cord-252871-qfrpuy3t 44 11 , , , cord-252871-qfrpuy3t 44 12 [ [ -LRB- cord-252871-qfrpuy3t 44 13 12 12 CD cord-252871-qfrpuy3t 44 14 ] ] -RRB- cord-252871-qfrpuy3t 44 15 [ [ -LRB- cord-252871-qfrpuy3t 44 16 13 13 CD cord-252871-qfrpuy3t 44 17 ] ] -RRB- cord-252871-qfrpuy3t 44 18 [ [ -LRB- cord-252871-qfrpuy3t 44 19 14 14 CD cord-252871-qfrpuy3t 44 20 ] ] -RRB- cord-252871-qfrpuy3t 44 21 [ [ -LRB- cord-252871-qfrpuy3t 44 22 15 15 CD cord-252871-qfrpuy3t 44 23 ] ] -RRB- cord-252871-qfrpuy3t 44 24 [ [ -LRB- cord-252871-qfrpuy3t 44 25 16 16 CD cord-252871-qfrpuy3t 44 26 ] ] -RRB- cord-252871-qfrpuy3t 44 27 that that WDT cord-252871-qfrpuy3t 44 28 overlooks overlook VBZ cord-252871-qfrpuy3t 44 29 the the DT cord-252871-qfrpuy3t 44 30 dramatic dramatic JJ cord-252871-qfrpuy3t 44 31 changes change NNS cord-252871-qfrpuy3t 44 32 viruses virus NNS cord-252871-qfrpuy3t 44 33 introduce introduce VBP cord-252871-qfrpuy3t 44 34 inside inside IN cord-252871-qfrpuy3t 44 35 infected infected JJ cord-252871-qfrpuy3t 44 36 cells cell NNS cord-252871-qfrpuy3t 44 37 . . . cord-252871-qfrpuy3t 45 1 A a DT cord-252871-qfrpuy3t 45 2 virus virus NN cord-252871-qfrpuy3t 45 3 - - HYPH cord-252871-qfrpuy3t 45 4 infected infect VBN cord-252871-qfrpuy3t 45 5 cell cell NN cord-252871-qfrpuy3t 45 6 can can MD cord-252871-qfrpuy3t 45 7 effectively effectively RB cord-252871-qfrpuy3t 45 8 be be VB cord-252871-qfrpuy3t 45 9 transformed transform VBN cord-252871-qfrpuy3t 45 10 into into IN cord-252871-qfrpuy3t 45 11 a a DT cord-252871-qfrpuy3t 45 12 ' ' `` cord-252871-qfrpuy3t 45 13 hot hot JJ cord-252871-qfrpuy3t 45 14 spot spot NN cord-252871-qfrpuy3t 45 15 ' ' '' cord-252871-qfrpuy3t 45 16 for for IN cord-252871-qfrpuy3t 45 17 virion virion NN cord-252871-qfrpuy3t 45 18 production production NN cord-252871-qfrpuy3t 45 19 [ [ -LRB- cord-252871-qfrpuy3t 45 20 17 17 CD cord-252871-qfrpuy3t 45 21 ] ] -RRB- cord-252871-qfrpuy3t 45 22 and and CC cord-252871-qfrpuy3t 45 23 can can MD cord-252871-qfrpuy3t 45 24 practically practically RB cord-252871-qfrpuy3t 45 25 lose lose VB cord-252871-qfrpuy3t 45 26 its -PRON- PRP$ cord-252871-qfrpuy3t 45 27 identity identity NN cord-252871-qfrpuy3t 45 28 ( ( -LRB- cord-252871-qfrpuy3t 45 29 i.e. i.e. FW cord-252871-qfrpuy3t 45 30 , , , cord-252871-qfrpuy3t 45 31 it -PRON- PRP cord-252871-qfrpuy3t 45 32 now now RB cord-252871-qfrpuy3t 45 33 produces produce VBZ cord-252871-qfrpuy3t 45 34 virions virion NNS cord-252871-qfrpuy3t 45 35 rather rather RB cord-252871-qfrpuy3t 45 36 than than IN cord-252871-qfrpuy3t 45 37 two two CD cord-252871-qfrpuy3t 45 38 daughter daughter NN cord-252871-qfrpuy3t 45 39 cells cell NNS cord-252871-qfrpuy3t 45 40 ) ) -RRB- cord-252871-qfrpuy3t 45 41 [ [ -LRB- cord-252871-qfrpuy3t 45 42 18 18 CD cord-252871-qfrpuy3t 45 43 ] ] -RRB- cord-252871-qfrpuy3t 45 44 . . . cord-252871-qfrpuy3t 46 1 In in IN cord-252871-qfrpuy3t 46 2 some some DT cord-252871-qfrpuy3t 46 3 viral viral JJ cord-252871-qfrpuy3t 46 4 infections infection NNS cord-252871-qfrpuy3t 46 5 , , , cord-252871-qfrpuy3t 46 6 large large JJ cord-252871-qfrpuy3t 46 7 cell cell NN cord-252871-qfrpuy3t 46 8 - - HYPH cord-252871-qfrpuy3t 46 9 like like JJ cord-252871-qfrpuy3t 46 10 ' ' '' cord-252871-qfrpuy3t 46 11 virion virion NN cord-252871-qfrpuy3t 46 12 factories factory NNS cord-252871-qfrpuy3t 46 13 ' ' '' cord-252871-qfrpuy3t 46 14 are be VBP cord-252871-qfrpuy3t 46 15 clearly clearly RB cord-252871-qfrpuy3t 46 16 visible visible JJ cord-252871-qfrpuy3t 46 17 [ [ -LRB- cord-252871-qfrpuy3t 46 18 19 19 CD cord-252871-qfrpuy3t 46 19 ] ] -RRB- cord-252871-qfrpuy3t 46 20 . . . cord-252871-qfrpuy3t 47 1 This this DT cord-252871-qfrpuy3t 47 2 remarkable remarkable JJ cord-252871-qfrpuy3t 47 3 transformation transformation NN cord-252871-qfrpuy3t 47 4 is be VBZ cord-252871-qfrpuy3t 47 5 due due JJ cord-252871-qfrpuy3t 47 6 to to IN cord-252871-qfrpuy3t 47 7 the the DT cord-252871-qfrpuy3t 47 8 virus virus NN cord-252871-qfrpuy3t 47 9 - - HYPH cord-252871-qfrpuy3t 47 10 mediated mediate VBN cord-252871-qfrpuy3t 47 11 manipulation manipulation NN cord-252871-qfrpuy3t 47 12 and and CC cord-252871-qfrpuy3t 47 13 alteration alteration NN cord-252871-qfrpuy3t 47 14 of of IN cord-252871-qfrpuy3t 47 15 host host NN cord-252871-qfrpuy3t 47 16 metabolism metabolism NN cord-252871-qfrpuy3t 47 17 and and CC cord-252871-qfrpuy3t 47 18 defenses defense NNS cord-252871-qfrpuy3t 47 19 [ [ -LRB- cord-252871-qfrpuy3t 47 20 7 7 CD cord-252871-qfrpuy3t 47 21 ] ] -RRB- cord-252871-qfrpuy3t 47 22 . . . cord-252871-qfrpuy3t 48 1 The the DT cord-252871-qfrpuy3t 48 2 intracellular intracellular JJ cord-252871-qfrpuy3t 48 3 stage stage NN cord-252871-qfrpuy3t 48 4 therefore therefore RB cord-252871-qfrpuy3t 48 5 involves involve VBZ cord-252871-qfrpuy3t 48 6 substantial substantial JJ cord-252871-qfrpuy3t 48 7 viral viral JJ cord-252871-qfrpuy3t 48 8 activity activity NN cord-252871-qfrpuy3t 48 9 and and CC cord-252871-qfrpuy3t 48 10 is be VBZ cord-252871-qfrpuy3t 48 11 often often RB cord-252871-qfrpuy3t 48 12 the the DT cord-252871-qfrpuy3t 48 13 target target NN cord-252871-qfrpuy3t 48 14 of of IN cord-252871-qfrpuy3t 48 15 antiviral antiviral JJ cord-252871-qfrpuy3t 48 16 drugs drug NNS cord-252871-qfrpuy3t 48 17 to to TO cord-252871-qfrpuy3t 48 18 combat combat VB cord-252871-qfrpuy3t 48 19 virus virus NN cord-252871-qfrpuy3t 48 20 infection infection NN cord-252871-qfrpuy3t 48 21 ( ( -LRB- cord-252871-qfrpuy3t 48 22 e.g. e.g. RB cord-252871-qfrpuy3t 48 23 , , , cord-252871-qfrpuy3t 48 24 antivirals antiviral NNS cord-252871-qfrpuy3t 48 25 that that WDT cord-252871-qfrpuy3t 48 26 target target VBP cord-252871-qfrpuy3t 48 27 HIV HIV NNP cord-252871-qfrpuy3t 48 28 polymerase polymerase NN cord-252871-qfrpuy3t 48 29 ) ) -RRB- cord-252871-qfrpuy3t 48 30 . . . cord-252871-qfrpuy3t 49 1 Despite despite IN cord-252871-qfrpuy3t 49 2 its -PRON- PRP$ cord-252871-qfrpuy3t 49 3 immense immense JJ cord-252871-qfrpuy3t 49 4 role role NN cord-252871-qfrpuy3t 49 5 in in IN cord-252871-qfrpuy3t 49 6 establishing establish VBG cord-252871-qfrpuy3t 49 7 virus virus NN cord-252871-qfrpuy3t 49 8 infection infection NN cord-252871-qfrpuy3t 49 9 and and CC cord-252871-qfrpuy3t 49 10 existence existence NN cord-252871-qfrpuy3t 49 11 inside inside IN cord-252871-qfrpuy3t 49 12 the the DT cord-252871-qfrpuy3t 49 13 infected infected JJ cord-252871-qfrpuy3t 49 14 cells cell NNS cord-252871-qfrpuy3t 49 15 , , , cord-252871-qfrpuy3t 49 16 it -PRON- PRP cord-252871-qfrpuy3t 49 17 has have VBZ cord-252871-qfrpuy3t 49 18 unfortunately unfortunately RB cord-252871-qfrpuy3t 49 19 been be VBN cord-252871-qfrpuy3t 49 20 referred refer VBN cord-252871-qfrpuy3t 49 21 to to IN cord-252871-qfrpuy3t 49 22 as as IN cord-252871-qfrpuy3t 49 23 the the DT cord-252871-qfrpuy3t 49 24 ' ' `` cord-252871-qfrpuy3t 49 25 eclipse eclipse NN cord-252871-qfrpuy3t 49 26 ' ' '' cord-252871-qfrpuy3t 49 27 or or CC cord-252871-qfrpuy3t 49 28 ' ' `` cord-252871-qfrpuy3t 49 29 vegetative vegetative JJ cord-252871-qfrpuy3t 49 30 ' ' '' cord-252871-qfrpuy3t 49 31 phase phase NN cord-252871-qfrpuy3t 49 32 [ [ -LRB- cord-252871-qfrpuy3t 49 33 20 20 CD cord-252871-qfrpuy3t 49 34 , , , cord-252871-qfrpuy3t 49 35 21 21 CD cord-252871-qfrpuy3t 49 36 ] ] -RRB- cord-252871-qfrpuy3t 49 37 to to TO cord-252871-qfrpuy3t 49 38 indicate indicate VB cord-252871-qfrpuy3t 49 39 lack lack NN cord-252871-qfrpuy3t 49 40 of of IN cord-252871-qfrpuy3t 49 41 hallmark hallmark JJ cord-252871-qfrpuy3t 49 42 signs sign NNS cord-252871-qfrpuy3t 49 43 of of IN cord-252871-qfrpuy3t 49 44 virus virus NN cord-252871-qfrpuy3t 49 45 infection infection NN cord-252871-qfrpuy3t 49 46 ( ( -LRB- cord-252871-qfrpuy3t 49 47 e.g. e.g. RB cord-252871-qfrpuy3t 49 48 , , , cord-252871-qfrpuy3t 49 49 virion virion NN cord-252871-qfrpuy3t 49 50 production production NN cord-252871-qfrpuy3t 49 51 , , , cord-252871-qfrpuy3t 49 52 plaques plaque NNS cord-252871-qfrpuy3t 49 53 , , , cord-252871-qfrpuy3t 49 54 and and CC cord-252871-qfrpuy3t 49 55 cell cell NN cord-252871-qfrpuy3t 49 56 rupture rupture NN cord-252871-qfrpuy3t 49 57 ) ) -RRB- cord-252871-qfrpuy3t 49 58 and and CC cord-252871-qfrpuy3t 49 59 ignored ignore VBN cord-252871-qfrpuy3t 49 60 in in IN cord-252871-qfrpuy3t 49 61 the the DT cord-252871-qfrpuy3t 49 62 definitions definition NNS cord-252871-qfrpuy3t 49 63 and and CC cord-252871-qfrpuy3t 49 64 descriptions description NNS cord-252871-qfrpuy3t 49 65 of of IN cord-252871-qfrpuy3t 49 66 viruses virus NNS cord-252871-qfrpuy3t 49 67 . . . cord-252871-qfrpuy3t 50 1 As as IN cord-252871-qfrpuy3t 50 2 suggested suggest VBN cord-252871-qfrpuy3t 50 3 by by IN cord-252871-qfrpuy3t 50 4 Jean Jean NNP cord-252871-qfrpuy3t 50 5 - - HYPH cord-252871-qfrpuy3t 50 6 Michel Michel NNP cord-252871-qfrpuy3t 50 7 Claverie Claverie NNP cord-252871-qfrpuy3t 50 8 , , , cord-252871-qfrpuy3t 50 9 virion virion NN cord-252871-qfrpuy3t 50 10 factory factory NN cord-252871-qfrpuy3t 50 11 better well RBR cord-252871-qfrpuy3t 50 12 represents represent VBZ cord-252871-qfrpuy3t 50 13 the the DT cord-252871-qfrpuy3t 50 14 ' ' `` cord-252871-qfrpuy3t 50 15 virus virus NN cord-252871-qfrpuy3t 50 16 self self NN cord-252871-qfrpuy3t 50 17 ' ' '' cord-252871-qfrpuy3t 50 18 and and CC cord-252871-qfrpuy3t 50 19 virions virion NNS cord-252871-qfrpuy3t 50 20 are be VBP cord-252871-qfrpuy3t 50 21 simply simply RB cord-252871-qfrpuy3t 50 22 means mean VBZ cord-252871-qfrpuy3t 50 23 to to TO cord-252871-qfrpuy3t 50 24 disseminate disseminate VB cord-252871-qfrpuy3t 50 25 genetic genetic JJ cord-252871-qfrpuy3t 50 26 information information NN cord-252871-qfrpuy3t 50 27 much much JJ cord-252871-qfrpuy3t 50 28 like like IN cord-252871-qfrpuy3t 50 29 human human JJ cord-252871-qfrpuy3t 50 30 gametes gamete NNS cord-252871-qfrpuy3t 50 31 and and CC cord-252871-qfrpuy3t 50 32 plant plant NN cord-252871-qfrpuy3t 50 33 seeds seed NNS cord-252871-qfrpuy3t 50 34 [ [ -LRB- cord-252871-qfrpuy3t 50 35 12 12 CD cord-252871-qfrpuy3t 50 36 ] ] -RRB- cord-252871-qfrpuy3t 50 37 . . . cord-252871-qfrpuy3t 51 1 In in IN cord-252871-qfrpuy3t 51 2 other other JJ cord-252871-qfrpuy3t 51 3 words word NNS cord-252871-qfrpuy3t 51 4 , , , cord-252871-qfrpuy3t 51 5 we -PRON- PRP cord-252871-qfrpuy3t 51 6 should should MD cord-252871-qfrpuy3t 51 7 depart depart VB cord-252871-qfrpuy3t 51 8 from from IN cord-252871-qfrpuy3t 51 9 the the DT cord-252871-qfrpuy3t 51 10 established establish VBN cord-252871-qfrpuy3t 51 11 usage usage NN cord-252871-qfrpuy3t 51 12 of of IN cord-252871-qfrpuy3t 51 13 the the DT cord-252871-qfrpuy3t 51 14 word word NN cord-252871-qfrpuy3t 51 15 ' ' `` cord-252871-qfrpuy3t 51 16 virus virus NN cord-252871-qfrpuy3t 51 17 ' ' '' cord-252871-qfrpuy3t 51 18 as as IN cord-252871-qfrpuy3t 51 19 being be VBG cord-252871-qfrpuy3t 51 20 synonymous synonymous JJ cord-252871-qfrpuy3t 51 21 to to IN cord-252871-qfrpuy3t 51 22 ' ' `` cord-252871-qfrpuy3t 51 23 virion virion NN cord-252871-qfrpuy3t 51 24 ' ' '' cord-252871-qfrpuy3t 51 25 . . . cord-252871-qfrpuy3t 52 1 The the DT cord-252871-qfrpuy3t 52 2 term term NN cord-252871-qfrpuy3t 52 3 ' ' `` cord-252871-qfrpuy3t 52 4 virus virus NN cord-252871-qfrpuy3t 52 5 ' ' '' cord-252871-qfrpuy3t 52 6 should should MD cord-252871-qfrpuy3t 52 7 refer refer VB cord-252871-qfrpuy3t 52 8 to to IN cord-252871-qfrpuy3t 52 9 the the DT cord-252871-qfrpuy3t 52 10 process process NN cord-252871-qfrpuy3t 52 11 encompassing encompass VBG cord-252871-qfrpuy3t 52 12 all all DT cord-252871-qfrpuy3t 52 13 phases phase NNS cord-252871-qfrpuy3t 52 14 of of IN cord-252871-qfrpuy3t 52 15 the the DT cord-252871-qfrpuy3t 52 16 virus virus NN cord-252871-qfrpuy3t 52 17 infection infection NN cord-252871-qfrpuy3t 52 18 cycle cycle NN cord-252871-qfrpuy3t 52 19 [ [ -LRB- cord-252871-qfrpuy3t 52 20 3 3 CD cord-252871-qfrpuy3t 52 21 ] ] -RRB- cord-252871-qfrpuy3t 52 22 . . . cord-252871-qfrpuy3t 53 1 In in IN cord-252871-qfrpuy3t 53 2 this this DT cord-252871-qfrpuy3t 53 3 context context NN cord-252871-qfrpuy3t 53 4 , , , cord-252871-qfrpuy3t 53 5 questioning question VBG cord-252871-qfrpuy3t 53 6 the the DT cord-252871-qfrpuy3t 53 7 origin origin NN cord-252871-qfrpuy3t 53 8 of of IN cord-252871-qfrpuy3t 53 9 ' ' `` cord-252871-qfrpuy3t 53 10 viruses virus NNS cord-252871-qfrpuy3t 53 11 ' ' '' cord-252871-qfrpuy3t 53 12 takes take VBZ cord-252871-qfrpuy3t 53 13 a a DT cord-252871-qfrpuy3t 53 14 completely completely RB cord-252871-qfrpuy3t 53 15 different different JJ cord-252871-qfrpuy3t 53 16 and and CC cord-252871-qfrpuy3t 53 17 much much RB cord-252871-qfrpuy3t 53 18 broader broad JJR cord-252871-qfrpuy3t 53 19 meaning meaning NN cord-252871-qfrpuy3t 53 20 than than IN cord-252871-qfrpuy3t 53 21 simply simply RB cord-252871-qfrpuy3t 53 22 questioning question VBG cord-252871-qfrpuy3t 53 23 the the DT cord-252871-qfrpuy3t 53 24 origin origin NN cord-252871-qfrpuy3t 53 25 of of IN cord-252871-qfrpuy3t 53 26 the the DT cord-252871-qfrpuy3t 53 27 virus virus NN cord-252871-qfrpuy3t 53 28 particles particle NNS cord-252871-qfrpuy3t 53 29 [ [ -LRB- cord-252871-qfrpuy3t 53 30 2 2 CD cord-252871-qfrpuy3t 53 31 , , , cord-252871-qfrpuy3t 53 32 11 11 CD cord-252871-qfrpuy3t 53 33 , , , cord-252871-qfrpuy3t 53 34 13 13 CD cord-252871-qfrpuy3t 53 35 , , , cord-252871-qfrpuy3t 53 36 16 16 CD cord-252871-qfrpuy3t 53 37 ] ] -RRB- cord-252871-qfrpuy3t 53 38 . . . cord-252871-qfrpuy3t 54 1 The the DT cord-252871-qfrpuy3t 54 2 virion virion NN cord-252871-qfrpuy3t 54 3 - - : cord-252871-qfrpuy3t 54 4 and and CC cord-252871-qfrpuy3t 54 5 host host NN cord-252871-qfrpuy3t 54 6 - - HYPH cord-252871-qfrpuy3t 54 7 centric centric NN cord-252871-qfrpuy3t 54 8 virus virus NN cord-252871-qfrpuy3t 54 9 definitions definition NNS cord-252871-qfrpuy3t 54 10 can can MD cord-252871-qfrpuy3t 54 11 cause cause VB cord-252871-qfrpuy3t 54 12 ambiguities ambiguity NNS cord-252871-qfrpuy3t 54 13 in in IN cord-252871-qfrpuy3t 54 14 distinguishing distinguish VBG cord-252871-qfrpuy3t 54 15 different different JJ cord-252871-qfrpuy3t 54 16 viral viral JJ cord-252871-qfrpuy3t 54 17 lineages lineage NNS cord-252871-qfrpuy3t 54 18 and and CC cord-252871-qfrpuy3t 54 19 even even RB cord-252871-qfrpuy3t 54 20 viruses virus NNS cord-252871-qfrpuy3t 54 21 from from IN cord-252871-qfrpuy3t 54 22 cellular cellular JJ cord-252871-qfrpuy3t 54 23 organisms organism NNS cord-252871-qfrpuy3t 54 24 . . . cord-252871-qfrpuy3t 55 1 For for IN cord-252871-qfrpuy3t 55 2 example example NN cord-252871-qfrpuy3t 55 3 , , , cord-252871-qfrpuy3t 55 4 Forterre Forterre NNP cord-252871-qfrpuy3t 55 5 recently recently RB cord-252871-qfrpuy3t 55 6 proposed propose VBD cord-252871-qfrpuy3t 55 7 to to TO cord-252871-qfrpuy3t 55 8 redefine redefine VB cord-252871-qfrpuy3t 55 9 viruses virus NNS cord-252871-qfrpuy3t 55 10 as as IN cord-252871-qfrpuy3t 55 11 ' ' `` cord-252871-qfrpuy3t 55 12 capsid capsid NN cord-252871-qfrpuy3t 55 13 - - HYPH cord-252871-qfrpuy3t 55 14 encoding encode VBG cord-252871-qfrpuy3t 55 15 organisms organism NNS cord-252871-qfrpuy3t 55 16 ' ' '' cord-252871-qfrpuy3t 55 17 [ [ -LRB- cord-252871-qfrpuy3t 55 18 22 22 CD cord-252871-qfrpuy3t 55 19 ] ] -RRB- cord-252871-qfrpuy3t 55 20 and and CC cord-252871-qfrpuy3t 55 21 later later RB cord-252871-qfrpuy3t 55 22 as as IN cord-252871-qfrpuy3t 55 23 ' ' `` cord-252871-qfrpuy3t 55 24 virion virion NN cord-252871-qfrpuy3t 55 25 - - HYPH cord-252871-qfrpuy3t 55 26 encoding encode VBG cord-252871-qfrpuy3t 55 27 organisms organism NNS cord-252871-qfrpuy3t 55 28 ' ' POS cord-252871-qfrpuy3t 55 29 [ [ -LRB- cord-252871-qfrpuy3t 55 30 2 2 CD cord-252871-qfrpuy3t 55 31 ] ] -RRB- cord-252871-qfrpuy3t 55 32 . . . cord-252871-qfrpuy3t 56 1 Both both DT cord-252871-qfrpuy3t 56 2 definitions definition NNS cord-252871-qfrpuy3t 56 3 recognize recognize VBP cord-252871-qfrpuy3t 56 4 viruses virus NNS cord-252871-qfrpuy3t 56 5 as as IN cord-252871-qfrpuy3t 56 6 ' ' `` cord-252871-qfrpuy3t 56 7 organisms organism NNS cord-252871-qfrpuy3t 56 8 ' ' '' cord-252871-qfrpuy3t 56 9 that that WDT cord-252871-qfrpuy3t 56 10 produce produce VBP cord-252871-qfrpuy3t 56 11 capsids capsid NNS cord-252871-qfrpuy3t 56 12 / / SYM cord-252871-qfrpuy3t 56 13 virions virion NNS cord-252871-qfrpuy3t 56 14 and and CC cord-252871-qfrpuy3t 56 15 rightly rightly RB cord-252871-qfrpuy3t 56 16 put put VB cord-252871-qfrpuy3t 56 17 emphasis emphasis NN cord-252871-qfrpuy3t 56 18 back back RB cord-252871-qfrpuy3t 56 19 on on IN cord-252871-qfrpuy3t 56 20 the the DT cord-252871-qfrpuy3t 56 21 intracellular intracellular JJ cord-252871-qfrpuy3t 56 22 stage stage NN cord-252871-qfrpuy3t 56 23 of of IN cord-252871-qfrpuy3t 56 24 virus virus NN cord-252871-qfrpuy3t 56 25 infection infection NN cord-252871-qfrpuy3t 56 26 cycle cycle NN cord-252871-qfrpuy3t 56 27 . . . cord-252871-qfrpuy3t 57 1 However however RB cord-252871-qfrpuy3t 57 2 , , , cord-252871-qfrpuy3t 57 3 these these DT cord-252871-qfrpuy3t 57 4 views view NNS cord-252871-qfrpuy3t 57 5 suffer suffer VBP cord-252871-qfrpuy3t 57 6 from from IN cord-252871-qfrpuy3t 57 7 our -PRON- PRP$ cord-252871-qfrpuy3t 57 8 ' ' `` cord-252871-qfrpuy3t 57 9 human human JJ cord-252871-qfrpuy3t 57 10 ' ' '' cord-252871-qfrpuy3t 57 11 habit habit NN cord-252871-qfrpuy3t 57 12 of of IN cord-252871-qfrpuy3t 57 13 classifying classify VBG cord-252871-qfrpuy3t 57 14 biological biological JJ cord-252871-qfrpuy3t 57 15 entities entity NNS cord-252871-qfrpuy3t 57 16 based base VBN cord-252871-qfrpuy3t 57 17 on on IN cord-252871-qfrpuy3t 57 18 the the DT cord-252871-qfrpuy3t 57 19 presence presence NN cord-252871-qfrpuy3t 57 20 / / SYM cord-252871-qfrpuy3t 57 21 absence absence NN cord-252871-qfrpuy3t 57 22 or or CC cord-252871-qfrpuy3t 57 23 contrast contrast NN cord-252871-qfrpuy3t 57 24 of of IN cord-252871-qfrpuy3t 57 25 physical physical JJ cord-252871-qfrpuy3t 57 26 and and CC cord-252871-qfrpuy3t 57 27 genetic genetic JJ cord-252871-qfrpuy3t 57 28 features feature NNS cord-252871-qfrpuy3t 57 29 . . . cord-252871-qfrpuy3t 58 1 As as IN cord-252871-qfrpuy3t 58 2 we -PRON- PRP cord-252871-qfrpuy3t 58 3 discuss discuss VBP cord-252871-qfrpuy3t 58 4 later later RB cord-252871-qfrpuy3t 58 5 , , , cord-252871-qfrpuy3t 58 6 such such JJ cord-252871-qfrpuy3t 58 7 definitions definition NNS cord-252871-qfrpuy3t 58 8 rarely rarely RB cord-252871-qfrpuy3t 58 9 withstand withstand VBP cord-252871-qfrpuy3t 58 10 the the DT cord-252871-qfrpuy3t 58 11 test test NN cord-252871-qfrpuy3t 58 12 of of IN cord-252871-qfrpuy3t 58 13 time time NN cord-252871-qfrpuy3t 58 14 and and CC cord-252871-qfrpuy3t 58 15 are be VBP cord-252871-qfrpuy3t 58 16 vulnerable vulnerable JJ cord-252871-qfrpuy3t 58 17 to to TO cord-252871-qfrpuy3t 58 18 change change VB cord-252871-qfrpuy3t 58 19 with with IN cord-252871-qfrpuy3t 58 20 new new JJ cord-252871-qfrpuy3t 58 21 discoveries discovery NNS cord-252871-qfrpuy3t 58 22 . . . cord-252871-qfrpuy3t 59 1 For for IN cord-252871-qfrpuy3t 59 2 example example NN cord-252871-qfrpuy3t 59 3 , , , cord-252871-qfrpuy3t 59 4 viruses virus NNS cord-252871-qfrpuy3t 59 5 were be VBD cord-252871-qfrpuy3t 59 6 long long RB cord-252871-qfrpuy3t 59 7 considered consider VBN cord-252871-qfrpuy3t 59 8 tiny tiny JJ cord-252871-qfrpuy3t 59 9 and and CC cord-252871-qfrpuy3t 59 10 submicroscopic submicroscopic JJ cord-252871-qfrpuy3t 59 11 biological biological JJ cord-252871-qfrpuy3t 59 12 entities entity NNS cord-252871-qfrpuy3t 59 13 ( ( -LRB- cord-252871-qfrpuy3t 59 14 properties property NNS cord-252871-qfrpuy3t 59 15 that that WDT cord-252871-qfrpuy3t 59 16 describe describe VBP cord-252871-qfrpuy3t 59 17 virions virion NNS cord-252871-qfrpuy3t 59 18 not not RB cord-252871-qfrpuy3t 59 19 viruses virus NNS cord-252871-qfrpuy3t 59 20 ! ! . cord-252871-qfrpuy3t 59 21 ) ) -RRB- cord-252871-qfrpuy3t 60 1 before before IN cord-252871-qfrpuy3t 60 2 the the DT cord-252871-qfrpuy3t 60 3 discovery discovery NN cord-252871-qfrpuy3t 60 4 of of IN cord-252871-qfrpuy3t 60 5 ' ' `` cord-252871-qfrpuy3t 60 6 giant giant JJ cord-252871-qfrpuy3t 60 7 viruses virus NNS cord-252871-qfrpuy3t 60 8 ' ' '' cord-252871-qfrpuy3t 60 9 with with IN cord-252871-qfrpuy3t 60 10 genomes genome NNS cord-252871-qfrpuy3t 60 11 and and CC cord-252871-qfrpuy3t 60 12 virions virion NNS cord-252871-qfrpuy3t 60 13 bigger big JJR cord-252871-qfrpuy3t 60 14 than than IN cord-252871-qfrpuy3t 60 15 the the DT cord-252871-qfrpuy3t 60 16 genomes genome NNS cord-252871-qfrpuy3t 60 17 and and CC cord-252871-qfrpuy3t 60 18 sizes size NNS cord-252871-qfrpuy3t 60 19 of of IN cord-252871-qfrpuy3t 60 20 many many JJ cord-252871-qfrpuy3t 60 21 parasitic parasitic JJ cord-252871-qfrpuy3t 60 22 cells cell NNS cord-252871-qfrpuy3t 60 23 [ [ -LRB- cord-252871-qfrpuy3t 60 24 23 23 CD cord-252871-qfrpuy3t 60 25 ] ] -RRB- cord-252871-qfrpuy3t 60 26 [ [ -LRB- cord-252871-qfrpuy3t 60 27 24 24 CD cord-252871-qfrpuy3t 60 28 ] ] -RRB- cord-252871-qfrpuy3t 60 29 [ [ -LRB- cord-252871-qfrpuy3t 60 30 25 25 CD cord-252871-qfrpuy3t 60 31 ] ] -RRB- cord-252871-qfrpuy3t 60 32 . . . cord-252871-qfrpuy3t 61 1 In in IN cord-252871-qfrpuy3t 61 2 fact fact NN cord-252871-qfrpuy3t 61 3 , , , cord-252871-qfrpuy3t 61 4 holding hold VBG cord-252871-qfrpuy3t 61 5 onto onto IN cord-252871-qfrpuy3t 61 6 the the DT cord-252871-qfrpuy3t 61 7 century century NN cord-252871-qfrpuy3t 61 8 - - HYPH cord-252871-qfrpuy3t 61 9 old old JJ cord-252871-qfrpuy3t 61 10 size size NN cord-252871-qfrpuy3t 61 11 / / SYM cord-252871-qfrpuy3t 61 12 shape shape NN cord-252871-qfrpuy3t 61 13 virion virion NN cord-252871-qfrpuy3t 61 14 - - HYPH cord-252871-qfrpuy3t 61 15 centric centric NN cord-252871-qfrpuy3t 61 16 definitions definition NNS cord-252871-qfrpuy3t 61 17 delayed delay VBD cord-252871-qfrpuy3t 61 18 the the DT cord-252871-qfrpuy3t 61 19 discovery discovery NN cord-252871-qfrpuy3t 61 20 of of IN cord-252871-qfrpuy3t 61 21 giant giant JJ cord-252871-qfrpuy3t 61 22 viruses virus NNS cord-252871-qfrpuy3t 61 23 by by IN cord-252871-qfrpuy3t 61 24 more more JJR cord-252871-qfrpuy3t 61 25 than than IN cord-252871-qfrpuy3t 61 26 a a DT cord-252871-qfrpuy3t 61 27 decade decade NN cord-252871-qfrpuy3t 61 28 . . . cord-252871-qfrpuy3t 62 1 2 2 LS cord-252871-qfrpuy3t 63 1 Similarly similarly RB cord-252871-qfrpuy3t 63 2 , , , cord-252871-qfrpuy3t 63 3 some some DT cord-252871-qfrpuy3t 63 4 scientists scientist NNS cord-252871-qfrpuy3t 63 5 consider consider VBP cord-252871-qfrpuy3t 63 6 viruses virus NNS cord-252871-qfrpuy3t 63 7 ' ' POS cord-252871-qfrpuy3t 63 8 non non JJ cord-252871-qfrpuy3t 63 9 - - JJ cord-252871-qfrpuy3t 63 10 living living JJ cord-252871-qfrpuy3t 63 11 ' ' '' cord-252871-qfrpuy3t 63 12 because because IN cord-252871-qfrpuy3t 63 13 they -PRON- PRP cord-252871-qfrpuy3t 63 14 do do VBP cord-252871-qfrpuy3t 63 15 not not RB cord-252871-qfrpuy3t 63 16 encode encode VB cord-252871-qfrpuy3t 63 17 metabolismrelated metabolismrelated JJ cord-252871-qfrpuy3t 63 18 genes gene NNS cord-252871-qfrpuy3t 63 19 [ [ -LRB- cord-252871-qfrpuy3t 63 20 1 1 CD cord-252871-qfrpuy3t 63 21 ] ] -RRB- cord-252871-qfrpuy3t 63 22 . . . cord-252871-qfrpuy3t 64 1 However however RB cord-252871-qfrpuy3t 64 2 , , , cord-252871-qfrpuy3t 64 3 this this DT cord-252871-qfrpuy3t 64 4 feature feature NN cord-252871-qfrpuy3t 64 5 is be VBZ cord-252871-qfrpuy3t 64 6 neither neither CC cord-252871-qfrpuy3t 64 7 unique unique JJ cord-252871-qfrpuy3t 64 8 nor nor CC cord-252871-qfrpuy3t 64 9 common common JJ cord-252871-qfrpuy3t 64 10 to to IN cord-252871-qfrpuy3t 64 11 all all DT cord-252871-qfrpuy3t 64 12 viruses virus NNS cord-252871-qfrpuy3t 64 13 . . . cord-252871-qfrpuy3t 65 1 Many many JJ cord-252871-qfrpuy3t 65 2 endosymbiotic endosymbiotic JJ cord-252871-qfrpuy3t 65 3 cellular cellular JJ cord-252871-qfrpuy3t 65 4 organisms organism NNS cord-252871-qfrpuy3t 65 5 are be VBP cord-252871-qfrpuy3t 65 6 also also RB cord-252871-qfrpuy3t 65 7 characterized characterize VBN cord-252871-qfrpuy3t 65 8 by by IN cord-252871-qfrpuy3t 65 9 extremely extremely RB cord-252871-qfrpuy3t 65 10 reduced reduce VBN cord-252871-qfrpuy3t 65 11 metabolic metabolic JJ cord-252871-qfrpuy3t 65 12 and and CC cord-252871-qfrpuy3t 65 13 translational translational JJ cord-252871-qfrpuy3t 65 14 machineries machinery NNS cord-252871-qfrpuy3t 65 15 [ [ -LRB- cord-252871-qfrpuy3t 65 16 26 26 CD cord-252871-qfrpuy3t 65 17 ] ] -RRB- cord-252871-qfrpuy3t 65 18 [ [ -LRB- cord-252871-qfrpuy3t 65 19 27 27 CD cord-252871-qfrpuy3t 65 20 ] ] -RRB- cord-252871-qfrpuy3t 65 21 [ [ -LRB- cord-252871-qfrpuy3t 65 22 28 28 CD cord-252871-qfrpuy3t 65 23 ] ] -RRB- cord-252871-qfrpuy3t 65 24 , , , cord-252871-qfrpuy3t 65 25 and and CC cord-252871-qfrpuy3t 65 26 recent recent JJ cord-252871-qfrpuy3t 65 27 metagenomic metagenomic NN cord-252871-qfrpuy3t 65 28 surveys survey NNS cord-252871-qfrpuy3t 65 29 have have VBP cord-252871-qfrpuy3t 65 30 verified verify VBN cord-252871-qfrpuy3t 65 31 the the DT cord-252871-qfrpuy3t 65 32 existence existence NN cord-252871-qfrpuy3t 65 33 of of IN cord-252871-qfrpuy3t 65 34 several several JJ cord-252871-qfrpuy3t 65 35 , , , cord-252871-qfrpuy3t 65 36 and and CC cord-252871-qfrpuy3t 65 37 likely likely RB cord-252871-qfrpuy3t 65 38 very very RB cord-252871-qfrpuy3t 65 39 ancient ancient JJ cord-252871-qfrpuy3t 65 40 , , , cord-252871-qfrpuy3t 65 41 metabolic metabolic JJ cord-252871-qfrpuy3t 65 42 genes gene NNS cord-252871-qfrpuy3t 65 43 in in IN cord-252871-qfrpuy3t 65 44 the the DT cord-252871-qfrpuy3t 65 45 genomes genome NNS cord-252871-qfrpuy3t 65 46 of of IN cord-252871-qfrpuy3t 65 47 giant giant JJ cord-252871-qfrpuy3t 65 48 viruses virus NNS cord-252871-qfrpuy3t 65 49 [ [ -LRB- cord-252871-qfrpuy3t 65 50 7 7 CD cord-252871-qfrpuy3t 65 51 ] ] -RRB- cord-252871-qfrpuy3t 65 52 . . . cord-252871-qfrpuy3t 66 1 These these DT cord-252871-qfrpuy3t 66 2 genes gene NNS cord-252871-qfrpuy3t 66 3 likely likely RB cord-252871-qfrpuy3t 66 4 help help VBP cord-252871-qfrpuy3t 66 5 reconfigure reconfigure VB cord-252871-qfrpuy3t 66 6 the the DT cord-252871-qfrpuy3t 66 7 metabolism metabolism NN cord-252871-qfrpuy3t 66 8 of of IN cord-252871-qfrpuy3t 66 9 infected infected JJ cord-252871-qfrpuy3t 66 10 cells cell NNS cord-252871-qfrpuy3t 66 11 during during IN cord-252871-qfrpuy3t 66 12 virus virus NN cord-252871-qfrpuy3t 66 13 infection infection NN cord-252871-qfrpuy3t 66 14 [ [ -LRB- cord-252871-qfrpuy3t 66 15 7 7 CD cord-252871-qfrpuy3t 66 16 ] ] -RRB- cord-252871-qfrpuy3t 66 17 . . . cord-252871-qfrpuy3t 67 1 Endosymbiosis endosymbiosis NN cord-252871-qfrpuy3t 67 2 : : : cord-252871-qfrpuy3t 67 3 the the DT cord-252871-qfrpuy3t 67 4 intimate intimate JJ cord-252871-qfrpuy3t 67 5 existence existence NN cord-252871-qfrpuy3t 67 6 of of IN cord-252871-qfrpuy3t 67 7 organisms organism NNS cord-252871-qfrpuy3t 67 8 inside inside IN cord-252871-qfrpuy3t 67 9 the the DT cord-252871-qfrpuy3t 67 10 cells cell NNS cord-252871-qfrpuy3t 67 11 or or CC cord-252871-qfrpuy3t 67 12 body body NN cord-252871-qfrpuy3t 67 13 of of IN cord-252871-qfrpuy3t 67 14 other other JJ cord-252871-qfrpuy3t 67 15 organisms organism NNS cord-252871-qfrpuy3t 67 16 . . . cord-252871-qfrpuy3t 68 1 Notable notable JJ cord-252871-qfrpuy3t 68 2 examples example NNS cord-252871-qfrpuy3t 68 3 include include VBP cord-252871-qfrpuy3t 68 4 endosymbiosis endosymbiosis NN cord-252871-qfrpuy3t 68 5 of of IN cord-252871-qfrpuy3t 68 6 the the DT cord-252871-qfrpuy3t 68 7 ancestors ancestor NNS cord-252871-qfrpuy3t 68 8 of of IN cord-252871-qfrpuy3t 68 9 mitochondria mitochondrion NNS cord-252871-qfrpuy3t 68 10 and and CC cord-252871-qfrpuy3t 68 11 chloroplasts chloroplast NNS cord-252871-qfrpuy3t 68 12 by by IN cord-252871-qfrpuy3t 68 13 proto proto NN cord-252871-qfrpuy3t 68 14 - - NNS cord-252871-qfrpuy3t 68 15 eukaryotes eukaryote NNS cord-252871-qfrpuy3t 68 16 or or CC cord-252871-qfrpuy3t 68 17 the the DT cord-252871-qfrpuy3t 68 18 ancestors ancestor NNS cord-252871-qfrpuy3t 68 19 of of IN cord-252871-qfrpuy3t 68 20 eukaryotes eukaryote NNS cord-252871-qfrpuy3t 68 21 . . . cord-252871-qfrpuy3t 69 1 Last last JJ cord-252871-qfrpuy3t 69 2 universal universal JJ cord-252871-qfrpuy3t 69 3 common common JJ cord-252871-qfrpuy3t 69 4 ancestor ancestor NN cord-252871-qfrpuy3t 69 5 ( ( -LRB- cord-252871-qfrpuy3t 69 6 LUCA LUCA NNP cord-252871-qfrpuy3t 69 7 ) ) -RRB- cord-252871-qfrpuy3t 69 8 : : : cord-252871-qfrpuy3t 69 9 the the DT cord-252871-qfrpuy3t 69 10 common common JJ cord-252871-qfrpuy3t 69 11 ancestor ancestor NN cord-252871-qfrpuy3t 69 12 of of IN cord-252871-qfrpuy3t 69 13 modern modern JJ cord-252871-qfrpuy3t 69 14 cells cell NNS cord-252871-qfrpuy3t 69 15 , , , cord-252871-qfrpuy3t 69 16 Archaea Archaea NNP cord-252871-qfrpuy3t 69 17 , , , cord-252871-qfrpuy3t 69 18 Bacteria Bacteria NNPS cord-252871-qfrpuy3t 69 19 , , , cord-252871-qfrpuy3t 69 20 and and CC cord-252871-qfrpuy3t 69 21 Eukarya Eukarya NNP cord-252871-qfrpuy3t 69 22 . . . cord-252871-qfrpuy3t 70 1 LUCA LUCA NNP cord-252871-qfrpuy3t 70 2 was be VBD cord-252871-qfrpuy3t 70 3 not not RB cord-252871-qfrpuy3t 70 4 the the DT cord-252871-qfrpuy3t 70 5 first first JJ cord-252871-qfrpuy3t 70 6 cell cell NN cord-252871-qfrpuy3t 70 7 . . . cord-252871-qfrpuy3t 71 1 It -PRON- PRP cord-252871-qfrpuy3t 71 2 was be VBD cord-252871-qfrpuy3t 71 3 the the DT cord-252871-qfrpuy3t 71 4 last last JJ cord-252871-qfrpuy3t 71 5 population population NN cord-252871-qfrpuy3t 71 6 of of IN cord-252871-qfrpuy3t 71 7 cells cell NNS cord-252871-qfrpuy3t 71 8 that that WDT cord-252871-qfrpuy3t 71 9 diversified diversify VBD cord-252871-qfrpuy3t 71 10 into into IN cord-252871-qfrpuy3t 71 11 modern modern JJ cord-252871-qfrpuy3t 71 12 cells cell NNS cord-252871-qfrpuy3t 71 13 . . . cord-252871-qfrpuy3t 72 1 Orthologous Orthologous NNP cord-252871-qfrpuy3t 72 2 : : : cord-252871-qfrpuy3t 72 3 refers refer VBZ cord-252871-qfrpuy3t 72 4 to to IN cord-252871-qfrpuy3t 72 5 genes gene NNS cord-252871-qfrpuy3t 72 6 that that WDT cord-252871-qfrpuy3t 72 7 diverged diverge VBD cord-252871-qfrpuy3t 72 8 from from IN cord-252871-qfrpuy3t 72 9 the the DT cord-252871-qfrpuy3t 72 10 common common JJ cord-252871-qfrpuy3t 72 11 ancestor ancestor NN cord-252871-qfrpuy3t 72 12 as as IN cord-252871-qfrpuy3t 72 13 a a DT cord-252871-qfrpuy3t 72 14 result result NN cord-252871-qfrpuy3t 72 15 of of IN cord-252871-qfrpuy3t 72 16 speciation speciation NN cord-252871-qfrpuy3t 72 17 . . . cord-252871-qfrpuy3t 73 1 Tree tree NN cord-252871-qfrpuy3t 73 2 of of IN cord-252871-qfrpuy3t 73 3 life life NN cord-252871-qfrpuy3t 73 4 : : : cord-252871-qfrpuy3t 73 5 a a DT cord-252871-qfrpuy3t 73 6 diagram diagram NN cord-252871-qfrpuy3t 73 7 that that WDT cord-252871-qfrpuy3t 73 8 describes describe VBZ cord-252871-qfrpuy3t 73 9 the the DT cord-252871-qfrpuy3t 73 10 evolutionary evolutionary JJ cord-252871-qfrpuy3t 73 11 history history NN cord-252871-qfrpuy3t 73 12 among among IN cord-252871-qfrpuy3t 73 13 modern modern JJ cord-252871-qfrpuy3t 73 14 species specie NNS cord-252871-qfrpuy3t 73 15 using use VBG cord-252871-qfrpuy3t 73 16 the the DT cord-252871-qfrpuy3t 73 17 metaphors metaphor NNS cord-252871-qfrpuy3t 73 18 of of IN cord-252871-qfrpuy3t 73 19 branching branch VBG cord-252871-qfrpuy3t 73 20 patterns pattern NNS cord-252871-qfrpuy3t 73 21 , , , cord-252871-qfrpuy3t 73 22 roots root NNS cord-252871-qfrpuy3t 73 23 , , , cord-252871-qfrpuy3t 73 24 and and CC cord-252871-qfrpuy3t 73 25 leaves leave VBZ cord-252871-qfrpuy3t 73 26 to to TO cord-252871-qfrpuy3t 73 27 represent represent VB cord-252871-qfrpuy3t 73 28 evolutionary evolutionary JJ cord-252871-qfrpuy3t 73 29 relationships relationship NNS cord-252871-qfrpuy3t 73 30 , , , cord-252871-qfrpuy3t 73 31 ancestors ancestor NNS cord-252871-qfrpuy3t 73 32 , , , cord-252871-qfrpuy3t 73 33 and and CC cord-252871-qfrpuy3t 73 34 modern modern JJ cord-252871-qfrpuy3t 73 35 species specie NNS cord-252871-qfrpuy3t 73 36 , , , cord-252871-qfrpuy3t 73 37 respectively respectively RB cord-252871-qfrpuy3t 73 38 . . . cord-252871-qfrpuy3t 74 1 The the DT cord-252871-qfrpuy3t 74 2 topology topology NN cord-252871-qfrpuy3t 74 3 of of IN cord-252871-qfrpuy3t 74 4 the the DT cord-252871-qfrpuy3t 74 5 tree tree NN cord-252871-qfrpuy3t 74 6 of of IN cord-252871-qfrpuy3t 74 7 life life NN cord-252871-qfrpuy3t 74 8 and and CC cord-252871-qfrpuy3t 74 9 the the DT cord-252871-qfrpuy3t 74 10 place place NN cord-252871-qfrpuy3t 74 11 of of IN cord-252871-qfrpuy3t 74 12 viruses virus NNS cord-252871-qfrpuy3t 74 13 in in IN cord-252871-qfrpuy3t 74 14 the the DT cord-252871-qfrpuy3t 74 15 tree tree NN cord-252871-qfrpuy3t 74 16 are be VBP cord-252871-qfrpuy3t 74 17 hotly hotly RB cord-252871-qfrpuy3t 74 18 debated debate VBN cord-252871-qfrpuy3t 74 19 topics topic NNS cord-252871-qfrpuy3t 74 20 . . . cord-252871-qfrpuy3t 75 1 Virion virion NN cord-252871-qfrpuy3t 75 2 : : : cord-252871-qfrpuy3t 75 3 virus virus NN cord-252871-qfrpuy3t 75 4 particle particle NN cord-252871-qfrpuy3t 75 5 that that WDT cord-252871-qfrpuy3t 75 6 can can MD cord-252871-qfrpuy3t 75 7 be be VB cord-252871-qfrpuy3t 75 8 purified purify VBN cord-252871-qfrpuy3t 75 9 and and CC cord-252871-qfrpuy3t 75 10 visualized visualize VBN cord-252871-qfrpuy3t 75 11 . . . cord-252871-qfrpuy3t 76 1 The the DT cord-252871-qfrpuy3t 76 2 core core NN cord-252871-qfrpuy3t 76 3 of of IN cord-252871-qfrpuy3t 76 4 a a DT cord-252871-qfrpuy3t 76 5 virion virion NN cord-252871-qfrpuy3t 76 6 comprises comprise VBZ cord-252871-qfrpuy3t 76 7 the the DT cord-252871-qfrpuy3t 76 8 virus virus NN cord-252871-qfrpuy3t 76 9 nucleic nucleic JJ cord-252871-qfrpuy3t 76 10 acid acid NN cord-252871-qfrpuy3t 76 11 ( ( -LRB- cord-252871-qfrpuy3t 76 12 DNA DNA NNP cord-252871-qfrpuy3t 76 13 or or CC cord-252871-qfrpuy3t 76 14 RNA RNA NNP cord-252871-qfrpuy3t 76 15 ) ) -RRB- cord-252871-qfrpuy3t 76 16 enclosed enclose VBD cord-252871-qfrpuy3t 76 17 inside inside IN cord-252871-qfrpuy3t 76 18 a a DT cord-252871-qfrpuy3t 76 19 protein protein NN cord-252871-qfrpuy3t 76 20 shell shell NN cord-252871-qfrpuy3t 76 21 called call VBD cord-252871-qfrpuy3t 76 22 a a DT cord-252871-qfrpuy3t 76 23 capsid capsid NN cord-252871-qfrpuy3t 76 24 . . . cord-252871-qfrpuy3t 77 1 Virion virion NN cord-252871-qfrpuy3t 77 2 factories factory NNS cord-252871-qfrpuy3t 77 3 : : : cord-252871-qfrpuy3t 77 4 intracellular intracellular JJ cord-252871-qfrpuy3t 77 5 compartments compartment NNS cord-252871-qfrpuy3t 77 6 , , , cord-252871-qfrpuy3t 77 7 formed form VBN cord-252871-qfrpuy3t 77 8 inside inside RB cord-252871-qfrpuy3t 77 9 virusinfected virusinfected JJ cord-252871-qfrpuy3t 77 10 cells cell NNS cord-252871-qfrpuy3t 77 11 , , , cord-252871-qfrpuy3t 77 12 that that WDT cord-252871-qfrpuy3t 77 13 increase increase VBP cord-252871-qfrpuy3t 77 14 virus virus NN cord-252871-qfrpuy3t 77 15 replication replication NN cord-252871-qfrpuy3t 77 16 . . . cord-252871-qfrpuy3t 78 1 2 2 LS cord-252871-qfrpuy3t 79 1 The the DT cord-252871-qfrpuy3t 79 2 first first JJ cord-252871-qfrpuy3t 79 3 giant giant JJ cord-252871-qfrpuy3t 79 4 virus virus NN cord-252871-qfrpuy3t 79 5 , , , cord-252871-qfrpuy3t 79 6 Acanthamoeba Acanthamoeba NNP cord-252871-qfrpuy3t 79 7 polyphaga polyphaga NNP cord-252871-qfrpuy3t 79 8 mimivirusi mimivirusi NN cord-252871-qfrpuy3t 79 9 , , , cord-252871-qfrpuy3t 79 10 was be VBD cord-252871-qfrpuy3t 79 11 initially initially RB cord-252871-qfrpuy3t 79 12 mistaken mistake VBN cord-252871-qfrpuy3t 79 13 for for IN cord-252871-qfrpuy3t 79 14 a a DT cord-252871-qfrpuy3t 79 15 Gram gram NN cord-252871-qfrpuy3t 79 16 - - HYPH cord-252871-qfrpuy3t 79 17 positive positive JJ cord-252871-qfrpuy3t 79 18 bacterium bacterium NN cord-252871-qfrpuy3t 79 19 . . . cord-252871-qfrpuy3t 80 1 It -PRON- PRP cord-252871-qfrpuy3t 80 2 was be VBD cord-252871-qfrpuy3t 80 3 first first RB cord-252871-qfrpuy3t 80 4 discovered discover VBN cord-252871-qfrpuy3t 80 5 in in IN cord-252871-qfrpuy3t 80 6 1992 1992 CD cord-252871-qfrpuy3t 80 7 during during IN cord-252871-qfrpuy3t 80 8 a a DT cord-252871-qfrpuy3t 80 9 pneumonia pneumonia NN cord-252871-qfrpuy3t 80 10 outbreak outbreak NN cord-252871-qfrpuy3t 80 11 in in IN cord-252871-qfrpuy3t 80 12 Bradford Bradford NNP cord-252871-qfrpuy3t 80 13 , , , cord-252871-qfrpuy3t 80 14 UK UK NNP cord-252871-qfrpuy3t 80 15 and and CC cord-252871-qfrpuy3t 80 16 the the DT cord-252871-qfrpuy3t 80 17 large large JJ cord-252871-qfrpuy3t 80 18 size size NN cord-252871-qfrpuy3t 80 19 of of IN cord-252871-qfrpuy3t 80 20 its -PRON- PRP$ cord-252871-qfrpuy3t 80 21 virion virion NN cord-252871-qfrpuy3t 80 22 misled mislead VBD cord-252871-qfrpuy3t 80 23 scientists scientist NNS cord-252871-qfrpuy3t 80 24 to to TO cord-252871-qfrpuy3t 80 25 believe believe VB cord-252871-qfrpuy3t 80 26 that that IN cord-252871-qfrpuy3t 80 27 it -PRON- PRP cord-252871-qfrpuy3t 80 28 must must MD cord-252871-qfrpuy3t 80 29 be be VB cord-252871-qfrpuy3t 80 30 a a DT cord-252871-qfrpuy3t 80 31 bacterium bacterium NN cord-252871-qfrpuy3t 80 32 ( ( -LRB- cord-252871-qfrpuy3t 80 33 called call VBN cord-252871-qfrpuy3t 80 34 ' ' `` cord-252871-qfrpuy3t 80 35 Bradfordcoccus Bradfordcoccus NNP cord-252871-qfrpuy3t 80 36 ' ' '' cord-252871-qfrpuy3t 80 37 ) ) -RRB- cord-252871-qfrpuy3t 80 38 . . . cord-252871-qfrpuy3t 81 1 Its -PRON- PRP$ cord-252871-qfrpuy3t 81 2 virus virus NN cord-252871-qfrpuy3t 81 3 nature nature NN cord-252871-qfrpuy3t 81 4 was be VBD cord-252871-qfrpuy3t 81 5 finally finally RB cord-252871-qfrpuy3t 81 6 revealed reveal VBN cord-252871-qfrpuy3t 81 7 in in IN cord-252871-qfrpuy3t 81 8 2003 2003 CD cord-252871-qfrpuy3t 81 9 [ [ -LRB- cord-252871-qfrpuy3t 81 10 84 84 CD cord-252871-qfrpuy3t 81 11 ] ] -RRB- cord-252871-qfrpuy3t 81 12 and and CC cord-252871-qfrpuy3t 81 13 the the DT cord-252871-qfrpuy3t 81 14 virus virus NN cord-252871-qfrpuy3t 81 15 was be VBD cord-252871-qfrpuy3t 81 16 aptly aptly RB cord-252871-qfrpuy3t 81 17 named name VBN cord-252871-qfrpuy3t 81 18 ' ' `` cord-252871-qfrpuy3t 81 19 mimivirus mimivirus NNP cord-252871-qfrpuy3t 81 20 ' ' '' cord-252871-qfrpuy3t 81 21 for for IN cord-252871-qfrpuy3t 81 22 ' ' `` cord-252871-qfrpuy3t 81 23 bacteria bacteria NNS cord-252871-qfrpuy3t 81 24 - - HYPH cord-252871-qfrpuy3t 81 25 mimicking mimic VBG cord-252871-qfrpuy3t 81 26 virus virus NN cord-252871-qfrpuy3t 81 27 ' ' '' cord-252871-qfrpuy3t 81 28 . . . cord-252871-qfrpuy3t 82 1 This this DT cord-252871-qfrpuy3t 82 2 is be VBZ cord-252871-qfrpuy3t 82 3 a a DT cord-252871-qfrpuy3t 82 4 famous famous JJ cord-252871-qfrpuy3t 82 5 example example NN cord-252871-qfrpuy3t 82 6 where where WRB cord-252871-qfrpuy3t 82 7 adhering adhere VBG cord-252871-qfrpuy3t 82 8 to to IN cord-252871-qfrpuy3t 82 9 century century NN cord-252871-qfrpuy3t 82 10 - - HYPH cord-252871-qfrpuy3t 82 11 old old JJ cord-252871-qfrpuy3t 82 12 virion virion NN cord-252871-qfrpuy3t 82 13 and and CC cord-252871-qfrpuy3t 82 14 size size NN cord-252871-qfrpuy3t 82 15 - - HYPH cord-252871-qfrpuy3t 82 16 based base VBN cord-252871-qfrpuy3t 82 17 virus virus NN cord-252871-qfrpuy3t 82 18 definitions definition NNS cord-252871-qfrpuy3t 82 19 delayed delay VBD cord-252871-qfrpuy3t 82 20 a a DT cord-252871-qfrpuy3t 82 21 significant significant JJ cord-252871-qfrpuy3t 82 22 discovery discovery NN cord-252871-qfrpuy3t 82 23 . . . cord-252871-qfrpuy3t 83 1 Using use VBG cord-252871-qfrpuy3t 83 2 virion virion NN cord-252871-qfrpuy3t 83 3 or or CC cord-252871-qfrpuy3t 83 4 capsid capsid NN cord-252871-qfrpuy3t 83 5 to to TO cord-252871-qfrpuy3t 83 6 distinguish distinguish VB cord-252871-qfrpuy3t 83 7 viral viral JJ cord-252871-qfrpuy3t 83 8 lineages lineage NNS cord-252871-qfrpuy3t 83 9 and and CC cord-252871-qfrpuy3t 83 10 viruses virus NNS cord-252871-qfrpuy3t 83 11 from from IN cord-252871-qfrpuy3t 83 12 cells cell NNS cord-252871-qfrpuy3t 83 13 can can MD cord-252871-qfrpuy3t 83 14 generate generate VB cord-252871-qfrpuy3t 83 15 similar similar JJ cord-252871-qfrpuy3t 83 16 confusions confusion NNS cord-252871-qfrpuy3t 83 17 . . . cord-252871-qfrpuy3t 84 1 For for IN cord-252871-qfrpuy3t 84 2 example example NN cord-252871-qfrpuy3t 84 3 , , , cord-252871-qfrpuy3t 84 4 it -PRON- PRP cord-252871-qfrpuy3t 84 5 can can MD cord-252871-qfrpuy3t 84 6 complicate complicate VB cord-252871-qfrpuy3t 84 7 classifications classification NNS cord-252871-qfrpuy3t 84 8 for for IN cord-252871-qfrpuy3t 84 9 virus virus NN cord-252871-qfrpuy3t 84 10 - - HYPH cord-252871-qfrpuy3t 84 11 like like JJ cord-252871-qfrpuy3t 84 12 genetic genetic JJ cord-252871-qfrpuy3t 84 13 elements element NNS cord-252871-qfrpuy3t 84 14 and and CC cord-252871-qfrpuy3t 84 15 viruses virus NNS cord-252871-qfrpuy3t 84 16 that that WDT cord-252871-qfrpuy3t 84 17 either either CC cord-252871-qfrpuy3t 84 18 lack lack JJ cord-252871-qfrpuy3t 84 19 virions virion NNS cord-252871-qfrpuy3t 84 20 ( ( -LRB- cord-252871-qfrpuy3t 84 21 e.g. e.g. RB cord-252871-qfrpuy3t 84 22 , , , cord-252871-qfrpuy3t 84 23 plasmids plasmid NNS cord-252871-qfrpuy3t 84 24 , , , cord-252871-qfrpuy3t 84 25 viroids viroid NNS cord-252871-qfrpuy3t 84 26 [ [ -LRB- cord-252871-qfrpuy3t 84 27 29 29 CD cord-252871-qfrpuy3t 84 28 ] ] -RRB- cord-252871-qfrpuy3t 84 29 ) ) -RRB- cord-252871-qfrpuy3t 84 30 or or CC cord-252871-qfrpuy3t 84 31 encode encode VB cord-252871-qfrpuy3t 84 32 only only RB cord-252871-qfrpuy3t 84 33 part part NN cord-252871-qfrpuy3t 84 34 of of IN cord-252871-qfrpuy3t 84 35 the the DT cord-252871-qfrpuy3t 84 36 virion virion NN cord-252871-qfrpuy3t 84 37 ( ( -LRB- cord-252871-qfrpuy3t 84 38 e.g. e.g. RB cord-252871-qfrpuy3t 84 39 , , , cord-252871-qfrpuy3t 84 40 polydnaviruses polydnaviruse NNS cord-252871-qfrpuy3t 84 41 ) ) -RRB- cord-252871-qfrpuy3t 84 42 . . . cord-252871-qfrpuy3t 85 1 For for IN cord-252871-qfrpuy3t 85 2 example example NN cord-252871-qfrpuy3t 85 3 , , , cord-252871-qfrpuy3t 85 4 the the DT cord-252871-qfrpuy3t 85 5 genome genome NN cord-252871-qfrpuy3t 85 6 of of IN cord-252871-qfrpuy3t 85 7 polydnaviruses polydnaviruse NNS cord-252871-qfrpuy3t 85 8 is be VBZ cord-252871-qfrpuy3t 85 9 dispersed disperse VBN cord-252871-qfrpuy3t 85 10 within within IN cord-252871-qfrpuy3t 85 11 the the DT cord-252871-qfrpuy3t 85 12 genome genome NN cord-252871-qfrpuy3t 85 13 of of IN cord-252871-qfrpuy3t 85 14 parasitoid parasitoid NN cord-252871-qfrpuy3t 85 15 wasps wasp NNS cord-252871-qfrpuy3t 85 16 . . . cord-252871-qfrpuy3t 86 1 The the DT cord-252871-qfrpuy3t 86 2 polydnavirus polydnavirus NN cord-252871-qfrpuy3t 86 3 - - HYPH cord-252871-qfrpuy3t 86 4 associated associate VBN cord-252871-qfrpuy3t 86 5 wasps wasp NNS cord-252871-qfrpuy3t 86 6 encode encode VBP cord-252871-qfrpuy3t 86 7 the the DT cord-252871-qfrpuy3t 86 8 virion virion NN cord-252871-qfrpuy3t 86 9 packaging packaging NN cord-252871-qfrpuy3t 86 10 system system NN cord-252871-qfrpuy3t 86 11 and and CC cord-252871-qfrpuy3t 86 12 utilize utilize VB cord-252871-qfrpuy3t 86 13 virions virion NNS cord-252871-qfrpuy3t 86 14 as as IN cord-252871-qfrpuy3t 86 15 gene gene NN cord-252871-qfrpuy3t 86 16 delivery delivery NN cord-252871-qfrpuy3t 86 17 vectors vector NNS cord-252871-qfrpuy3t 86 18 to to TO cord-252871-qfrpuy3t 86 19 infect infect VB cord-252871-qfrpuy3t 86 20 caterpillars caterpillar NNS cord-252871-qfrpuy3t 86 21 [ [ -LRB- cord-252871-qfrpuy3t 86 22 30 30 CD cord-252871-qfrpuy3t 86 23 ] ] -RRB- cord-252871-qfrpuy3t 86 24 . . . cord-252871-qfrpuy3t 87 1 Since since IN cord-252871-qfrpuy3t 87 2 the the DT cord-252871-qfrpuy3t 87 3 virion virion NN cord-252871-qfrpuy3t 87 4 is be VBZ cord-252871-qfrpuy3t 87 5 encoded encode VBN cord-252871-qfrpuy3t 87 6 by by IN cord-252871-qfrpuy3t 87 7 the the DT cord-252871-qfrpuy3t 87 8 wasp wasp NN cord-252871-qfrpuy3t 87 9 genome genome NN cord-252871-qfrpuy3t 87 10 , , , cord-252871-qfrpuy3t 87 11 polydnavirus polydnavirus NNP cord-252871-qfrpuy3t 87 12 - - HYPH cord-252871-qfrpuy3t 87 13 associated associate VBN cord-252871-qfrpuy3t 87 14 wasps wasp NNS cord-252871-qfrpuy3t 87 15 may may MD cord-252871-qfrpuy3t 87 16 better well RBR cord-252871-qfrpuy3t 87 17 resemble resemble VB cord-252871-qfrpuy3t 87 18 virionencoding virionencode VBG cord-252871-qfrpuy3t 87 19 organisms organism NNS cord-252871-qfrpuy3t 87 20 under under IN cord-252871-qfrpuy3t 87 21 the the DT cord-252871-qfrpuy3t 87 22 virion virion NN cord-252871-qfrpuy3t 87 23 - - HYPH cord-252871-qfrpuy3t 87 24 centric centric NN cord-252871-qfrpuy3t 87 25 definition definition NN cord-252871-qfrpuy3t 87 26 [ [ -LRB- cord-252871-qfrpuy3t 87 27 31 31 CD cord-252871-qfrpuy3t 87 28 ] ] -RRB- cord-252871-qfrpuy3t 87 29 . . . cord-252871-qfrpuy3t 88 1 Similarly similarly RB cord-252871-qfrpuy3t 88 2 , , , cord-252871-qfrpuy3t 88 3 virus virus NN cord-252871-qfrpuy3t 88 4 - - HYPH cord-252871-qfrpuy3t 88 5 infected infect VBN cord-252871-qfrpuy3t 88 6 cells cell NNS cord-252871-qfrpuy3t 88 7 can can MD cord-252871-qfrpuy3t 88 8 excrete excrete VB cord-252871-qfrpuy3t 88 9 vesicles vesicle NNS cord-252871-qfrpuy3t 88 10 containing contain VBG cord-252871-qfrpuy3t 88 11 the the DT cord-252871-qfrpuy3t 88 12 virus virus NN cord-252871-qfrpuy3t 88 13 nucleic nucleic JJ cord-252871-qfrpuy3t 88 14 acid acid NN cord-252871-qfrpuy3t 88 15 , , , cord-252871-qfrpuy3t 88 16 [ [ -LRB- cord-252871-qfrpuy3t 88 17 32 32 CD cord-252871-qfrpuy3t 88 18 ] ] -RRB- cord-252871-qfrpuy3t 88 19 and and CC cord-252871-qfrpuy3t 88 20 healthy healthy JJ cord-252871-qfrpuy3t 88 21 cells cell NNS cord-252871-qfrpuy3t 88 22 routinely routinely RB cord-252871-qfrpuy3t 88 23 utilize utilize VBP cord-252871-qfrpuy3t 88 24 extracellular extracellular JJ cord-252871-qfrpuy3t 88 25 vesicles vesicle NNS cord-252871-qfrpuy3t 88 26 for for IN cord-252871-qfrpuy3t 88 27 genetic genetic JJ cord-252871-qfrpuy3t 88 28 communication communication NN cord-252871-qfrpuy3t 88 29 [ [ -LRB- cord-252871-qfrpuy3t 88 30 33 33 CD cord-252871-qfrpuy3t 88 31 ] ] -RRB- cord-252871-qfrpuy3t 88 32 . . . cord-252871-qfrpuy3t 89 1 These these DT cord-252871-qfrpuy3t 89 2 examples example NNS cord-252871-qfrpuy3t 89 3 generalize generalize VBP cord-252871-qfrpuy3t 89 4 the the DT cord-252871-qfrpuy3t 89 5 concept concept NN cord-252871-qfrpuy3t 89 6 and and CC cord-252871-qfrpuy3t 89 7 morphology morphology NN cord-252871-qfrpuy3t 89 8 of of IN cord-252871-qfrpuy3t 89 9 a a DT cord-252871-qfrpuy3t 89 10 ' ' `` cord-252871-qfrpuy3t 89 11 virion virion NN cord-252871-qfrpuy3t 89 12 ' ' '' cord-252871-qfrpuy3t 89 13 . . . cord-252871-qfrpuy3t 90 1 Similarly similarly RB cord-252871-qfrpuy3t 90 2 , , , cord-252871-qfrpuy3t 90 3 capsid capsid NN cord-252871-qfrpuy3t 90 4 - - HYPH cord-252871-qfrpuy3t 90 5 like like JJ cord-252871-qfrpuy3t 90 6 compartments compartment NNS cord-252871-qfrpuy3t 90 7 have have VBP cord-252871-qfrpuy3t 90 8 been be VBN cord-252871-qfrpuy3t 90 9 detected detect VBN cord-252871-qfrpuy3t 90 10 in in IN cord-252871-qfrpuy3t 90 11 cellular cellular JJ cord-252871-qfrpuy3t 90 12 organisms organism NNS cord-252871-qfrpuy3t 90 13 where where WRB cord-252871-qfrpuy3t 90 14 they -PRON- PRP cord-252871-qfrpuy3t 90 15 perform perform VBP cord-252871-qfrpuy3t 90 16 functions function NNS cord-252871-qfrpuy3t 90 17 such such JJ cord-252871-qfrpuy3t 90 18 as as IN cord-252871-qfrpuy3t 90 19 storage storage NN cord-252871-qfrpuy3t 90 20 of of IN cord-252871-qfrpuy3t 90 21 enzymes enzyme NNS cord-252871-qfrpuy3t 90 22 [ [ -LRB- cord-252871-qfrpuy3t 90 23 34 34 CD cord-252871-qfrpuy3t 90 24 ] ] -RRB- cord-252871-qfrpuy3t 90 25 , , , cord-252871-qfrpuy3t 90 26 and and CC cord-252871-qfrpuy3t 90 27 many many JJ cord-252871-qfrpuy3t 90 28 viral viral JJ cord-252871-qfrpuy3t 90 29 capsid capsid NN cord-252871-qfrpuy3t 90 30 proteins protein NNS cord-252871-qfrpuy3t 90 31 either either CC cord-252871-qfrpuy3t 90 32 evolved evolve VBD cord-252871-qfrpuy3t 90 33 directly directly RB cord-252871-qfrpuy3t 90 34 from from IN cord-252871-qfrpuy3t 90 35 cellular cellular JJ cord-252871-qfrpuy3t 90 36 proteins protein NNS cord-252871-qfrpuy3t 90 37 [ [ -LRB- cord-252871-qfrpuy3t 90 38 35 35 CD cord-252871-qfrpuy3t 90 39 ] ] -RRB- cord-252871-qfrpuy3t 90 40 or or CC cord-252871-qfrpuy3t 90 41 have have VBP cord-252871-qfrpuy3t 90 42 distant distant JJ cord-252871-qfrpuy3t 90 43 homologs homolog NNS cord-252871-qfrpuy3t 90 44 in in IN cord-252871-qfrpuy3t 90 45 cellular cellular JJ cord-252871-qfrpuy3t 90 46 genomes genome NNS cord-252871-qfrpuy3t 90 47 [ [ -LRB- cord-252871-qfrpuy3t 90 48 36 36 CD cord-252871-qfrpuy3t 90 49 ] ] -RRB- cord-252871-qfrpuy3t 90 50 . . . cord-252871-qfrpuy3t 91 1 These these DT cord-252871-qfrpuy3t 91 2 examples example NNS cord-252871-qfrpuy3t 91 3 blur blur VBP cord-252871-qfrpuy3t 91 4 the the DT cord-252871-qfrpuy3t 91 5 separation separation NN cord-252871-qfrpuy3t 91 6 of of IN cord-252871-qfrpuy3t 91 7 viruses virus NNS cord-252871-qfrpuy3t 91 8 from from IN cord-252871-qfrpuy3t 91 9 cells cell NNS cord-252871-qfrpuy3t 91 10 ( ( -LRB- cord-252871-qfrpuy3t 91 11 and and CC cord-252871-qfrpuy3t 91 12 other other JJ cord-252871-qfrpuy3t 91 13 parasitic parasitic JJ cord-252871-qfrpuy3t 91 14 genetic genetic JJ cord-252871-qfrpuy3t 91 15 elements element NNS cord-252871-qfrpuy3t 91 16 ) ) -RRB- cord-252871-qfrpuy3t 91 17 based base VBN cord-252871-qfrpuy3t 91 18 on on IN cord-252871-qfrpuy3t 91 19 the the DT cord-252871-qfrpuy3t 91 20 presence presence NN cord-252871-qfrpuy3t 91 21 / / SYM cord-252871-qfrpuy3t 91 22 absence absence NN cord-252871-qfrpuy3t 91 23 of of IN cord-252871-qfrpuy3t 91 24 physical physical JJ cord-252871-qfrpuy3t 91 25 or or CC cord-252871-qfrpuy3t 91 26 genetic genetic JJ cord-252871-qfrpuy3t 91 27 descriptors descriptor NNS cord-252871-qfrpuy3t 91 28 . . . cord-252871-qfrpuy3t 92 1 In in IN cord-252871-qfrpuy3t 92 2 sum sum NN cord-252871-qfrpuy3t 92 3 , , , cord-252871-qfrpuy3t 92 4 we -PRON- PRP cord-252871-qfrpuy3t 92 5 discourage discourage VBP cord-252871-qfrpuy3t 92 6 the the DT cord-252871-qfrpuy3t 92 7 use use NN cord-252871-qfrpuy3t 92 8 of of IN cord-252871-qfrpuy3t 92 9 any any DT cord-252871-qfrpuy3t 92 10 virus virus NN cord-252871-qfrpuy3t 92 11 definition definition NN cord-252871-qfrpuy3t 92 12 based base VBN cord-252871-qfrpuy3t 92 13 on on IN cord-252871-qfrpuy3t 92 14 the the DT cord-252871-qfrpuy3t 92 15 presence presence NN cord-252871-qfrpuy3t 92 16 or or CC cord-252871-qfrpuy3t 92 17 absence absence NN cord-252871-qfrpuy3t 92 18 of of IN cord-252871-qfrpuy3t 92 19 any any DT cord-252871-qfrpuy3t 92 20 subset subset NN cord-252871-qfrpuy3t 92 21 of of IN cord-252871-qfrpuy3t 92 22 genes gene NNS cord-252871-qfrpuy3t 92 23 or or CC cord-252871-qfrpuy3t 92 24 physical physical JJ cord-252871-qfrpuy3t 92 25 features feature NNS cord-252871-qfrpuy3t 92 26 ( ( -LRB- cord-252871-qfrpuy3t 92 27 e.g. e.g. RB cord-252871-qfrpuy3t 92 28 , , , cord-252871-qfrpuy3t 92 29 size size NN cord-252871-qfrpuy3t 92 30 , , , cord-252871-qfrpuy3t 92 31 morphology morphology NN cord-252871-qfrpuy3t 92 32 , , , cord-252871-qfrpuy3t 92 33 capsid capsid NN cord-252871-qfrpuy3t 92 34 proteins protein NNS cord-252871-qfrpuy3t 92 35 ) ) -RRB- cord-252871-qfrpuy3t 92 36 because because IN cord-252871-qfrpuy3t 92 37 such such JJ cord-252871-qfrpuy3t 92 38 definitions definition NNS cord-252871-qfrpuy3t 92 39 are be VBP cord-252871-qfrpuy3t 92 40 often often RB cord-252871-qfrpuy3t 92 41 ambiguous ambiguous JJ cord-252871-qfrpuy3t 92 42 , , , cord-252871-qfrpuy3t 92 43 not not RB cord-252871-qfrpuy3t 92 44 broadly broadly RB cord-252871-qfrpuy3t 92 45 applicable applicable JJ cord-252871-qfrpuy3t 92 46 , , , cord-252871-qfrpuy3t 92 47 and and CC cord-252871-qfrpuy3t 92 48 more more RBR cord-252871-qfrpuy3t 92 49 importantly importantly RB cord-252871-qfrpuy3t 92 50 prone prone JJ cord-252871-qfrpuy3t 92 51 to to TO cord-252871-qfrpuy3t 92 52 change change VB cord-252871-qfrpuy3t 92 53 with with IN cord-252871-qfrpuy3t 92 54 new new JJ cord-252871-qfrpuy3t 92 55 discoveries discovery NNS cord-252871-qfrpuy3t 92 56 . . . cord-252871-qfrpuy3t 93 1 We -PRON- PRP cord-252871-qfrpuy3t 93 2 assert assert VBP cord-252871-qfrpuy3t 93 3 that that IN cord-252871-qfrpuy3t 93 4 viruses virus NNS cord-252871-qfrpuy3t 93 5 can can MD cord-252871-qfrpuy3t 93 6 be be VB cord-252871-qfrpuy3t 93 7 better well RBR cord-252871-qfrpuy3t 93 8 defined define VBN cord-252871-qfrpuy3t 93 9 by by IN cord-252871-qfrpuy3t 93 10 their -PRON- PRP$ cord-252871-qfrpuy3t 93 11 generic generic JJ cord-252871-qfrpuy3t 93 12 properties property NNS cord-252871-qfrpuy3t 93 13 of of IN cord-252871-qfrpuy3t 93 14 genome genome NN cord-252871-qfrpuy3t 93 15 dissemination dissemination NN cord-252871-qfrpuy3t 93 16 and and CC cord-252871-qfrpuy3t 93 17 propagation propagation NN cord-252871-qfrpuy3t 93 18 [ [ -LRB- cord-252871-qfrpuy3t 93 19 11 11 CD cord-252871-qfrpuy3t 93 20 ] ] -RRB- cord-252871-qfrpuy3t 93 21 . . . cord-252871-qfrpuy3t 94 1 Viruses virus NNS cord-252871-qfrpuy3t 94 2 replicate replicate VBP cord-252871-qfrpuy3t 94 3 using use VBG cord-252871-qfrpuy3t 94 4 the the DT cord-252871-qfrpuy3t 94 5 macromolecular macromolecular JJ cord-252871-qfrpuy3t 94 6 machinery machinery NN cord-252871-qfrpuy3t 94 7 of of IN cord-252871-qfrpuy3t 94 8 other other JJ cord-252871-qfrpuy3t 94 9 biological biological JJ cord-252871-qfrpuy3t 94 10 entities entity NNS cord-252871-qfrpuy3t 94 11 . . . cord-252871-qfrpuy3t 95 1 This this DT cord-252871-qfrpuy3t 95 2 prong prong NN cord-252871-qfrpuy3t 95 3 establishes establish VBZ cord-252871-qfrpuy3t 95 4 absolute absolute JJ cord-252871-qfrpuy3t 95 5 parasitism parasitism NN cord-252871-qfrpuy3t 95 6 , , , cord-252871-qfrpuy3t 95 7 which which WDT cord-252871-qfrpuy3t 95 8 is be VBZ cord-252871-qfrpuy3t 95 9 a a DT cord-252871-qfrpuy3t 95 10 hallmark hallmark NN cord-252871-qfrpuy3t 95 11 of of IN cord-252871-qfrpuy3t 95 12 viruses virus NNS cord-252871-qfrpuy3t 95 13 and and CC cord-252871-qfrpuy3t 95 14 virus virus NN cord-252871-qfrpuy3t 95 15 - - HYPH cord-252871-qfrpuy3t 95 16 like like JJ cord-252871-qfrpuy3t 95 17 genetic genetic JJ cord-252871-qfrpuy3t 95 18 elements element NNS cord-252871-qfrpuy3t 95 19 . . . cord-252871-qfrpuy3t 96 1 Another another DT cord-252871-qfrpuy3t 96 2 feature feature NN cord-252871-qfrpuy3t 96 3 of of IN cord-252871-qfrpuy3t 96 4 viruses virus NNS cord-252871-qfrpuy3t 96 5 is be VBZ cord-252871-qfrpuy3t 96 6 the the DT cord-252871-qfrpuy3t 96 7 ability ability NN cord-252871-qfrpuy3t 96 8 to to TO cord-252871-qfrpuy3t 96 9 encapsulate encapsulate VB cord-252871-qfrpuy3t 96 10 and and CC cord-252871-qfrpuy3t 96 11 disseminate disseminate VB cord-252871-qfrpuy3t 96 12 genomes genome NNS cord-252871-qfrpuy3t 96 13 in in IN cord-252871-qfrpuy3t 96 14 metabolically metabolically RB cord-252871-qfrpuy3t 96 15 inert inert JJ cord-252871-qfrpuy3t 96 16 structures structure NNS cord-252871-qfrpuy3t 96 17 . . . cord-252871-qfrpuy3t 97 1 This this DT cord-252871-qfrpuy3t 97 2 prong prong NN cord-252871-qfrpuy3t 97 3 can can MD cord-252871-qfrpuy3t 97 4 also also RB cord-252871-qfrpuy3t 97 5 be be VB cord-252871-qfrpuy3t 97 6 generalized generalize VBN cord-252871-qfrpuy3t 97 7 , , , cord-252871-qfrpuy3t 97 8 and and CC cord-252871-qfrpuy3t 97 9 such such JJ cord-252871-qfrpuy3t 97 10 structures structure NNS cord-252871-qfrpuy3t 97 11 could could MD cord-252871-qfrpuy3t 97 12 be be VB cord-252871-qfrpuy3t 97 13 any any DT cord-252871-qfrpuy3t 97 14 type type NN cord-252871-qfrpuy3t 97 15 of of IN cord-252871-qfrpuy3t 97 16 infectious infectious JJ cord-252871-qfrpuy3t 97 17 particle particle NN cord-252871-qfrpuy3t 97 18 without without IN cord-252871-qfrpuy3t 97 19 constraints constraint NNS cord-252871-qfrpuy3t 97 20 of of IN cord-252871-qfrpuy3t 97 21 size size NN cord-252871-qfrpuy3t 97 22 , , , cord-252871-qfrpuy3t 97 23 shape shape NN cord-252871-qfrpuy3t 97 24 , , , cord-252871-qfrpuy3t 97 25 or or CC cord-252871-qfrpuy3t 97 26 biochemical biochemical JJ cord-252871-qfrpuy3t 97 27 composition composition NN cord-252871-qfrpuy3t 97 28 ( ( -LRB- cord-252871-qfrpuy3t 97 29 e.g. e.g. RB cord-252871-qfrpuy3t 97 30 , , , cord-252871-qfrpuy3t 97 31 vesicles vesicle NNS cord-252871-qfrpuy3t 97 32 ) ) -RRB- cord-252871-qfrpuy3t 97 33 [ [ -LRB- cord-252871-qfrpuy3t 97 34 37 37 CD cord-252871-qfrpuy3t 97 35 ] ] -RRB- cord-252871-qfrpuy3t 97 36 . . . cord-252871-qfrpuy3t 98 1 This this DT cord-252871-qfrpuy3t 98 2 definition definition NN cord-252871-qfrpuy3t 98 3 encompasses encompass VBZ cord-252871-qfrpuy3t 98 4 both both CC cord-252871-qfrpuy3t 98 5 the the DT cord-252871-qfrpuy3t 98 6 encapsulated encapsulated JJ cord-252871-qfrpuy3t 98 7 and and CC cord-252871-qfrpuy3t 98 8 non non JJ cord-252871-qfrpuy3t 98 9 - - JJ cord-252871-qfrpuy3t 98 10 encapsulated encapsulated JJ cord-252871-qfrpuy3t 98 11 genomes genome NNS cord-252871-qfrpuy3t 98 12 ( ( -LRB- cord-252871-qfrpuy3t 98 13 e.g. e.g. RB cord-252871-qfrpuy3t 98 14 , , , cord-252871-qfrpuy3t 98 15 plasmids plasmid NNS cord-252871-qfrpuy3t 98 16 ) ) -RRB- cord-252871-qfrpuy3t 98 17 and and CC cord-252871-qfrpuy3t 98 18 emphasizes emphasize VBZ cord-252871-qfrpuy3t 98 19 the the DT cord-252871-qfrpuy3t 98 20 generic generic JJ cord-252871-qfrpuy3t 98 21 feature feature NN cord-252871-qfrpuy3t 98 22 of of IN cord-252871-qfrpuy3t 98 23 how how WRB cord-252871-qfrpuy3t 98 24 viruses virus NNS cord-252871-qfrpuy3t 98 25 propagate propagate VBP cord-252871-qfrpuy3t 98 26 in in IN cord-252871-qfrpuy3t 98 27 cells cell NNS cord-252871-qfrpuy3t 98 28 rather rather RB cord-252871-qfrpuy3t 98 29 than than IN cord-252871-qfrpuy3t 98 30 being be VBG cord-252871-qfrpuy3t 98 31 dependent dependent JJ cord-252871-qfrpuy3t 98 32 on on IN cord-252871-qfrpuy3t 98 33 the the DT cord-252871-qfrpuy3t 98 34 presence presence NN cord-252871-qfrpuy3t 98 35 / / SYM cord-252871-qfrpuy3t 98 36 absence absence NN cord-252871-qfrpuy3t 98 37 of of IN cord-252871-qfrpuy3t 98 38 specific specific JJ cord-252871-qfrpuy3t 98 39 biomarkers biomarker NNS cord-252871-qfrpuy3t 98 40 [ [ -LRB- cord-252871-qfrpuy3t 98 41 11 11 CD cord-252871-qfrpuy3t 98 42 ] ] -RRB- cord-252871-qfrpuy3t 98 43 . . . cord-252871-qfrpuy3t 99 1 Under under IN cord-252871-qfrpuy3t 99 2 our -PRON- PRP$ cord-252871-qfrpuy3t 99 3 generic generic JJ cord-252871-qfrpuy3t 99 4 definition definition NN cord-252871-qfrpuy3t 99 5 , , , cord-252871-qfrpuy3t 99 6 virus virus NN cord-252871-qfrpuy3t 99 7 origin origin NN cord-252871-qfrpuy3t 99 8 must must MD cord-252871-qfrpuy3t 99 9 mean mean VB cord-252871-qfrpuy3t 99 10 the the DT cord-252871-qfrpuy3t 99 11 origin origin NN cord-252871-qfrpuy3t 99 12 of of IN cord-252871-qfrpuy3t 99 13 parasitism parasitism NN cord-252871-qfrpuy3t 99 14 and and CC cord-252871-qfrpuy3t 99 15 the the DT cord-252871-qfrpuy3t 99 16 subsequent subsequent JJ cord-252871-qfrpuy3t 99 17 ability ability NN cord-252871-qfrpuy3t 99 18 of of IN cord-252871-qfrpuy3t 99 19 those those DT cord-252871-qfrpuy3t 99 20 parasitic parasitic JJ cord-252871-qfrpuy3t 99 21 entities entity NNS cord-252871-qfrpuy3t 99 22 to to TO cord-252871-qfrpuy3t 99 23 propagate propagate VB cord-252871-qfrpuy3t 99 24 via via IN cord-252871-qfrpuy3t 99 25 the the DT cord-252871-qfrpuy3t 99 26 production production NN cord-252871-qfrpuy3t 99 27 of of IN cord-252871-qfrpuy3t 99 28 metabolically metabolically RB cord-252871-qfrpuy3t 99 29 inert inert JJ cord-252871-qfrpuy3t 99 30 structures structure NNS cord-252871-qfrpuy3t 99 31 . . . cord-252871-qfrpuy3t 100 1 Since since IN cord-252871-qfrpuy3t 100 2 all all DT cord-252871-qfrpuy3t 100 3 modern modern JJ cord-252871-qfrpuy3t 100 4 - - HYPH cord-252871-qfrpuy3t 100 5 day day NN cord-252871-qfrpuy3t 100 6 viruses virus NNS cord-252871-qfrpuy3t 100 7 strictly strictly RB cord-252871-qfrpuy3t 100 8 parasitize parasitize VBP cord-252871-qfrpuy3t 100 9 cells cell NNS cord-252871-qfrpuy3t 100 10 ( ( -LRB- cord-252871-qfrpuy3t 100 11 with with IN cord-252871-qfrpuy3t 100 12 the the DT cord-252871-qfrpuy3t 100 13 exception exception NN cord-252871-qfrpuy3t 100 14 of of IN cord-252871-qfrpuy3t 100 15 virophages virophage NNS cord-252871-qfrpuy3t 100 16 that that WDT cord-252871-qfrpuy3t 100 17 parasitize parasitize VBP cord-252871-qfrpuy3t 100 18 the the DT cord-252871-qfrpuy3t 100 19 viral viral JJ cord-252871-qfrpuy3t 100 20 factory factory NN cord-252871-qfrpuy3t 100 21 of of IN cord-252871-qfrpuy3t 100 22 other other JJ cord-252871-qfrpuy3t 100 23 viruses virus NNS cord-252871-qfrpuy3t 100 24 ) ) -RRB- cord-252871-qfrpuy3t 101 1 [ [ -LRB- cord-252871-qfrpuy3t 101 2 38 38 CD cord-252871-qfrpuy3t 101 3 , , , cord-252871-qfrpuy3t 101 4 39 39 CD cord-252871-qfrpuy3t 101 5 ] ] -RRB- cord-252871-qfrpuy3t 101 6 , , , cord-252871-qfrpuy3t 101 7 we -PRON- PRP cord-252871-qfrpuy3t 101 8 can can MD cord-252871-qfrpuy3t 101 9 assume assume VB cord-252871-qfrpuy3t 101 10 that that IN cord-252871-qfrpuy3t 101 11 virus virus NN cord-252871-qfrpuy3t 101 12 - - HYPH cord-252871-qfrpuy3t 101 13 mediated mediate VBN cord-252871-qfrpuy3t 101 14 parasitism parasitism NN cord-252871-qfrpuy3t 101 15 and and CC cord-252871-qfrpuy3t 101 16 propagation propagation NN cord-252871-qfrpuy3t 101 17 originated originate VBD cord-252871-qfrpuy3t 101 18 only only RB cord-252871-qfrpuy3t 101 19 after after IN cord-252871-qfrpuy3t 101 20 cells cell NNS cord-252871-qfrpuy3t 101 21 appeared appear VBD cord-252871-qfrpuy3t 101 22 in in IN cord-252871-qfrpuy3t 101 23 evolution evolution NN cord-252871-qfrpuy3t 101 24 as as IN cord-252871-qfrpuy3t 101 25 cells cell NNS cord-252871-qfrpuy3t 101 26 would would MD cord-252871-qfrpuy3t 101 27 provide provide VB cord-252871-qfrpuy3t 101 28 both both CC cord-252871-qfrpuy3t 101 29 the the DT cord-252871-qfrpuy3t 101 30 resources resource NNS cord-252871-qfrpuy3t 101 31 to to TO cord-252871-qfrpuy3t 101 32 parasitize parasitize VB cord-252871-qfrpuy3t 101 33 upon upon IN cord-252871-qfrpuy3t 101 34 and and CC cord-252871-qfrpuy3t 101 35 the the DT cord-252871-qfrpuy3t 101 36 means mean NNS cord-252871-qfrpuy3t 101 37 for for IN cord-252871-qfrpuy3t 101 38 genome genome NN cord-252871-qfrpuy3t 101 39 dissemination dissemination NN cord-252871-qfrpuy3t 101 40 ( ( -LRB- cord-252871-qfrpuy3t 101 41 e.g. e.g. RB cord-252871-qfrpuy3t 101 42 , , , cord-252871-qfrpuy3t 101 43 capsids capsid NNS cord-252871-qfrpuy3t 101 44 / / SYM cord-252871-qfrpuy3t 101 45 vesicles vesicle NNS cord-252871-qfrpuy3t 101 46 ) ) -RRB- cord-252871-qfrpuy3t 101 47 . . . cord-252871-qfrpuy3t 102 1 We -PRON- PRP cord-252871-qfrpuy3t 102 2 therefore therefore RB cord-252871-qfrpuy3t 102 3 rule rule VBP cord-252871-qfrpuy3t 102 4 out out RP cord-252871-qfrpuy3t 102 5 virus virus NN cord-252871-qfrpuy3t 102 6 existence existence NN cord-252871-qfrpuy3t 102 7 in in IN cord-252871-qfrpuy3t 102 8 a a DT cord-252871-qfrpuy3t 102 9 ' ' `` cord-252871-qfrpuy3t 102 10 pre pre JJ cord-252871-qfrpuy3t 102 11 - - JJ cord-252871-qfrpuy3t 102 12 cellular cellular JJ cord-252871-qfrpuy3t 102 13 ' ' '' cord-252871-qfrpuy3t 102 14 world world NN cord-252871-qfrpuy3t 102 15 as as IN cord-252871-qfrpuy3t 102 16 it -PRON- PRP cord-252871-qfrpuy3t 102 17 would would MD cord-252871-qfrpuy3t 102 18 be be VB cord-252871-qfrpuy3t 102 19 incompatible incompatible JJ cord-252871-qfrpuy3t 102 20 with with IN cord-252871-qfrpuy3t 102 21 the the DT cord-252871-qfrpuy3t 102 22 proposed propose VBN cord-252871-qfrpuy3t 102 23 virus virus NN cord-252871-qfrpuy3t 102 24 definition definition NN cord-252871-qfrpuy3t 102 25 ( ( -LRB- cord-252871-qfrpuy3t 102 26 Figure figure NN cord-252871-qfrpuy3t 102 27 1 1 CD cord-252871-qfrpuy3t 102 28 for for IN cord-252871-qfrpuy3t 102 29 comparative comparative JJ cord-252871-qfrpuy3t 102 30 scenarios scenario NNS cord-252871-qfrpuy3t 102 31 ) ) -RRB- cord-252871-qfrpuy3t 102 32 . . . cord-252871-qfrpuy3t 103 1 The the DT cord-252871-qfrpuy3t 103 2 next next JJ cord-252871-qfrpuy3t 103 3 logical logical JJ cord-252871-qfrpuy3t 103 4 questions question NNS cord-252871-qfrpuy3t 103 5 are be VBP cord-252871-qfrpuy3t 103 6 the the DT cord-252871-qfrpuy3t 103 7 timings timing NNS cord-252871-qfrpuy3t 103 8 and and CC cord-252871-qfrpuy3t 103 9 mechanisms mechanism NNS cord-252871-qfrpuy3t 103 10 of of IN cord-252871-qfrpuy3t 103 11 when when WRB cord-252871-qfrpuy3t 103 12 and and CC cord-252871-qfrpuy3t 103 13 how how WRB cord-252871-qfrpuy3t 103 14 the the DT cord-252871-qfrpuy3t 103 15 first first JJ cord-252871-qfrpuy3t 103 16 viruses virus NNS cord-252871-qfrpuy3t 103 17 appeared appear VBD cord-252871-qfrpuy3t 103 18 . . . cord-252871-qfrpuy3t 104 1 The the DT cord-252871-qfrpuy3t 104 2 former former JJ cord-252871-qfrpuy3t 104 3 question question NN cord-252871-qfrpuy3t 104 4 is be VBZ cord-252871-qfrpuy3t 104 5 relatively relatively RB cord-252871-qfrpuy3t 104 6 straightforward straightforward JJ cord-252871-qfrpuy3t 104 7 . . . cord-252871-qfrpuy3t 105 1 In in IN cord-252871-qfrpuy3t 105 2 our -PRON- PRP$ cord-252871-qfrpuy3t 105 3 view view NN cord-252871-qfrpuy3t 105 4 , , , cord-252871-qfrpuy3t 105 5 viruses virus NNS cord-252871-qfrpuy3t 105 6 originated originate VBD cord-252871-qfrpuy3t 105 7 from from IN cord-252871-qfrpuy3t 105 8 ' ' `` cord-252871-qfrpuy3t 105 9 ancient ancient JJ cord-252871-qfrpuy3t 105 10 ' ' '' cord-252871-qfrpuy3t 105 11 cells cell NNS cord-252871-qfrpuy3t 105 12 that that WDT cord-252871-qfrpuy3t 105 13 existed exist VBD cord-252871-qfrpuy3t 105 14 before before IN cord-252871-qfrpuy3t 105 15 the the DT cord-252871-qfrpuy3t 105 16 last last JJ cord-252871-qfrpuy3t 105 17 universal universal JJ cord-252871-qfrpuy3t 105 18 common common JJ cord-252871-qfrpuy3t 105 19 ancestor ancestor NN cord-252871-qfrpuy3t 105 20 ( ( -LRB- cord-252871-qfrpuy3t 105 21 LUCA LUCA NNP cord-252871-qfrpuy3t 105 22 ) ) -RRB- cord-252871-qfrpuy3t 105 23 diversified diversify VBD cord-252871-qfrpuy3t 105 24 into into IN cord-252871-qfrpuy3t 105 25 modern modern JJ cord-252871-qfrpuy3t 105 26 cells cell NNS cord-252871-qfrpuy3t 105 27 ( ( -LRB- cord-252871-qfrpuy3t 105 28 i.e. i.e. FW cord-252871-qfrpuy3t 105 29 , , , cord-252871-qfrpuy3t 105 30 the the DT cord-252871-qfrpuy3t 105 31 three three CD cord-252871-qfrpuy3t 105 32 superkingdoms superkingdom NNS cord-252871-qfrpuy3t 105 33 , , , cord-252871-qfrpuy3t 105 34 Archaea Archaea NNP cord-252871-qfrpuy3t 105 35 , , , cord-252871-qfrpuy3t 105 36 Bacteria Bacteria NNPS cord-252871-qfrpuy3t 105 37 , , , cord-252871-qfrpuy3t 105 38 and and CC cord-252871-qfrpuy3t 105 39 Eukarya Eukarya NNP cord-252871-qfrpuy3t 105 40 ) ) -RRB- cord-252871-qfrpuy3t 105 41 [ [ -LRB- cord-252871-qfrpuy3t 105 42 40 40 CD cord-252871-qfrpuy3t 105 43 ] ] -RRB- cord-252871-qfrpuy3t 105 44 . . . cord-252871-qfrpuy3t 106 1 3 3 LS cord-252871-qfrpuy3t 107 1 There there EX cord-252871-qfrpuy3t 107 2 are be VBP cord-252871-qfrpuy3t 107 3 multiple multiple JJ cord-252871-qfrpuy3t 107 4 lines line NNS cord-252871-qfrpuy3t 107 5 of of IN cord-252871-qfrpuy3t 107 6 evidence evidence NN cord-252871-qfrpuy3t 107 7 supporting support VBG cord-252871-qfrpuy3t 107 8 this this DT cord-252871-qfrpuy3t 107 9 timing timing NN cord-252871-qfrpuy3t 107 10 . . . cord-252871-qfrpuy3t 108 1 For for IN cord-252871-qfrpuy3t 108 2 example example NN cord-252871-qfrpuy3t 108 3 , , , cord-252871-qfrpuy3t 108 4 the the DT cord-252871-qfrpuy3t 108 5 genomes genome NNS cord-252871-qfrpuy3t 108 6 of of IN cord-252871-qfrpuy3t 108 7 archaeoviruses archaeoviruse NNS cord-252871-qfrpuy3t 108 8 , , , cord-252871-qfrpuy3t 108 9 bacterioviruses bacterioviruses NNPS cord-252871-qfrpuy3t 108 10 , , , cord-252871-qfrpuy3t 108 11 and and CC cord-252871-qfrpuy3t 108 12 eukaryoviruses eukaryoviruse NNS cord-252871-qfrpuy3t 108 13 , , , cord-252871-qfrpuy3t 108 14 are be VBP cord-252871-qfrpuy3t 108 15 characterized characterize VBN cord-252871-qfrpuy3t 108 16 by by IN cord-252871-qfrpuy3t 108 17 the the DT cord-252871-qfrpuy3t 108 18 abundance abundance NN cord-252871-qfrpuy3t 108 19 of of IN cord-252871-qfrpuy3t 108 20 virus virus NN cord-252871-qfrpuy3t 108 21 - - HYPH cord-252871-qfrpuy3t 108 22 specific specific JJ cord-252871-qfrpuy3t 108 23 genes gene NNS cord-252871-qfrpuy3t 108 24 that that WDT cord-252871-qfrpuy3t 108 25 lack lack VBP cord-252871-qfrpuy3t 108 26 detectable detectable JJ cord-252871-qfrpuy3t 108 27 homologs homolog NNS cord-252871-qfrpuy3t 108 28 in in IN cord-252871-qfrpuy3t 108 29 cellular cellular JJ cord-252871-qfrpuy3t 108 30 genomes genome NNS cord-252871-qfrpuy3t 108 31 [ [ -LRB- cord-252871-qfrpuy3t 108 32 41 41 CD cord-252871-qfrpuy3t 108 33 ] ] -RRB- cord-252871-qfrpuy3t 108 34 . . . cord-252871-qfrpuy3t 109 1 While while IN cord-252871-qfrpuy3t 109 2 these these DT cord-252871-qfrpuy3t 109 3 genes gene NNS cord-252871-qfrpuy3t 109 4 can can MD cord-252871-qfrpuy3t 109 5 be be VB cord-252871-qfrpuy3t 109 6 strain strain NN cord-252871-qfrpuy3t 109 7 - - HYPH cord-252871-qfrpuy3t 109 8 specific specific JJ cord-252871-qfrpuy3t 109 9 with with IN cord-252871-qfrpuy3t 109 10 a a DT cord-252871-qfrpuy3t 109 11 recent recent JJ cord-252871-qfrpuy3t 109 12 de de FW cord-252871-qfrpuy3t 109 13 novo novo NNP cord-252871-qfrpuy3t 109 14 origin origin NNP cord-252871-qfrpuy3t 109 15 [ [ -LRB- cord-252871-qfrpuy3t 109 16 42 42 CD cord-252871-qfrpuy3t 109 17 , , , cord-252871-qfrpuy3t 109 18 43 43 CD cord-252871-qfrpuy3t 109 19 ] ] -RRB- cord-252871-qfrpuy3t 109 20 , , , cord-252871-qfrpuy3t 109 21 their -PRON- PRP$ cord-252871-qfrpuy3t 109 22 abundance abundance NN cord-252871-qfrpuy3t 109 23 and and CC cord-252871-qfrpuy3t 109 24 existence existence NN cord-252871-qfrpuy3t 109 25 in in IN cord-252871-qfrpuy3t 109 26 diverse diverse JJ cord-252871-qfrpuy3t 109 27 virus virus NN cord-252871-qfrpuy3t 109 28 groups group NNS cord-252871-qfrpuy3t 109 29 suggests suggest VBZ cord-252871-qfrpuy3t 109 30 their -PRON- PRP$ cord-252871-qfrpuy3t 109 31 accumulation accumulation NN cord-252871-qfrpuy3t 109 32 likely likely RB cord-252871-qfrpuy3t 109 33 started start VBD cord-252871-qfrpuy3t 109 34 very very RB cord-252871-qfrpuy3t 109 35 early early RB cord-252871-qfrpuy3t 109 36 in in IN cord-252871-qfrpuy3t 109 37 evolution evolution NN cord-252871-qfrpuy3t 109 38 . . . cord-252871-qfrpuy3t 110 1 Similarly similarly RB cord-252871-qfrpuy3t 110 2 , , , cord-252871-qfrpuy3t 110 3 viral viral JJ cord-252871-qfrpuy3t 110 4 lineages lineage NNS cord-252871-qfrpuy3t 110 5 that that WDT cord-252871-qfrpuy3t 110 6 infect infect VBP cord-252871-qfrpuy3t 110 7 distantly distantly RB cord-252871-qfrpuy3t 110 8 related related JJ cord-252871-qfrpuy3t 110 9 hosts host NNS cord-252871-qfrpuy3t 110 10 from from IN cord-252871-qfrpuy3t 110 11 all all DT cord-252871-qfrpuy3t 110 12 three three CD cord-252871-qfrpuy3t 110 13 superkingdoms superkingdom NNS cord-252871-qfrpuy3t 110 14 share share VBP cord-252871-qfrpuy3t 110 15 several several JJ cord-252871-qfrpuy3t 110 16 conserved conserve VBN cord-252871-qfrpuy3t 110 17 three three CD cord-252871-qfrpuy3t 110 18 - - HYPH cord-252871-qfrpuy3t 110 19 dimensional dimensional JJ cord-252871-qfrpuy3t 110 20 ( ( -LRB- cord-252871-qfrpuy3t 110 21 3D 3D NNP cord-252871-qfrpuy3t 110 22 ) ) -RRB- cord-252871-qfrpuy3t 110 23 protein protein NN cord-252871-qfrpuy3t 110 24 structural structural JJ cord-252871-qfrpuy3t 110 25 folds fold NNS cord-252871-qfrpuy3t 110 26 that that WDT cord-252871-qfrpuy3t 110 27 also also RB cord-252871-qfrpuy3t 110 28 indicate indicate VBP cord-252871-qfrpuy3t 110 29 that that IN cord-252871-qfrpuy3t 110 30 these these DT cord-252871-qfrpuy3t 110 31 lineages lineage NNS cord-252871-qfrpuy3t 110 32 likely likely RB cord-252871-qfrpuy3t 110 33 existed exist VBD cord-252871-qfrpuy3t 110 34 prior prior RB cord-252871-qfrpuy3t 110 35 to to IN cord-252871-qfrpuy3t 110 36 LUCA LUCA NNP cord-252871-qfrpuy3t 110 37 diversification diversification NN cord-252871-qfrpuy3t 110 38 [ [ -LRB- cord-252871-qfrpuy3t 110 39 44 44 CD cord-252871-qfrpuy3t 110 40 ] ] -RRB- cord-252871-qfrpuy3t 110 41 . . . cord-252871-qfrpuy3t 111 1 New new JJ cord-252871-qfrpuy3t 111 2 viruses virus NNS cord-252871-qfrpuy3t 111 3 would would MD cord-252871-qfrpuy3t 111 4 then then RB cord-252871-qfrpuy3t 111 5 evolve evolve VB cord-252871-qfrpuy3t 111 6 from from IN cord-252871-qfrpuy3t 111 7 existing exist VBG cord-252871-qfrpuy3t 111 8 viruses virus NNS cord-252871-qfrpuy3t 111 9 via via IN cord-252871-qfrpuy3t 111 10 natural natural JJ cord-252871-qfrpuy3t 111 11 processes process NNS cord-252871-qfrpuy3t 111 12 such such JJ cord-252871-qfrpuy3t 111 13 as as IN cord-252871-qfrpuy3t 111 14 recombination recombination NN cord-252871-qfrpuy3t 111 15 and and CC cord-252871-qfrpuy3t 111 16 in in IN cord-252871-qfrpuy3t 111 17 response response NN cord-252871-qfrpuy3t 111 18 to to IN cord-252871-qfrpuy3t 111 19 new new JJ cord-252871-qfrpuy3t 111 20 and and CC cord-252871-qfrpuy3t 111 21 emerging emerge VBG cord-252871-qfrpuy3t 111 22 hosts host NNS cord-252871-qfrpuy3t 111 23 . . . cord-252871-qfrpuy3t 112 1 The the DT cord-252871-qfrpuy3t 112 2 mechanisms mechanism NNS cord-252871-qfrpuy3t 112 3 of of IN cord-252871-qfrpuy3t 112 4 how how WRB cord-252871-qfrpuy3t 112 5 ancient ancient JJ cord-252871-qfrpuy3t 112 6 cells cell NNS cord-252871-qfrpuy3t 112 7 evolved evolve VBD cord-252871-qfrpuy3t 112 8 into into IN cord-252871-qfrpuy3t 112 9 viruses virus NNS cord-252871-qfrpuy3t 112 10 are be VBP cord-252871-qfrpuy3t 112 11 relatively relatively RB cord-252871-qfrpuy3t 112 12 less less RBR cord-252871-qfrpuy3t 112 13 clear clear JJ cord-252871-qfrpuy3t 112 14 . . . cord-252871-qfrpuy3t 113 1 Krupovic Krupovic NNP cord-252871-qfrpuy3t 113 2 et et NNP cord-252871-qfrpuy3t 113 3 al al NNP cord-252871-qfrpuy3t 113 4 . . . cord-252871-qfrpuy3t 114 1 recently recently RB cord-252871-qfrpuy3t 114 2 proposed propose VBD cord-252871-qfrpuy3t 114 3 a a DT cord-252871-qfrpuy3t 114 4 hybrid hybrid JJ cord-252871-qfrpuy3t 114 5 model model NN cord-252871-qfrpuy3t 114 6 to to TO cord-252871-qfrpuy3t 114 7 answer answer VB cord-252871-qfrpuy3t 114 8 this this DT cord-252871-qfrpuy3t 114 9 question question NN cord-252871-qfrpuy3t 114 10 [ [ -LRB- cord-252871-qfrpuy3t 114 11 45 45 CD cord-252871-qfrpuy3t 114 12 ] ] -RRB- cord-252871-qfrpuy3t 114 13 . . . cord-252871-qfrpuy3t 115 1 According accord VBG cord-252871-qfrpuy3t 115 2 to to IN cord-252871-qfrpuy3t 115 3 their -PRON- PRP$ cord-252871-qfrpuy3t 115 4 model model NN cord-252871-qfrpuy3t 115 5 , , , cord-252871-qfrpuy3t 115 6 viral viral JJ cord-252871-qfrpuy3t 115 7 nucleic nucleic JJ cord-252871-qfrpuy3t 115 8 acids acid NNS cord-252871-qfrpuy3t 115 9 evolved evolve VBN cord-252871-qfrpuy3t 115 10 in in IN cord-252871-qfrpuy3t 115 11 the the DT cord-252871-qfrpuy3t 115 12 pre pre JJ cord-252871-qfrpuy3t 115 13 - - JJ cord-252871-qfrpuy3t 115 14 cellular cellular JJ cord-252871-qfrpuy3t 115 15 world world NN cord-252871-qfrpuy3t 115 16 and and CC cord-252871-qfrpuy3t 115 17 virus virus NN cord-252871-qfrpuy3t 115 18 propagation propagation NN cord-252871-qfrpuy3t 115 19 mechanisms mechanism NNS cord-252871-qfrpuy3t 115 20 evolved evolve VBD cord-252871-qfrpuy3t 115 21 via via IN cord-252871-qfrpuy3t 115 22 the the DT cord-252871-qfrpuy3t 115 23 modification modification NN cord-252871-qfrpuy3t 115 24 of of IN cord-252871-qfrpuy3t 115 25 cellular cellular JJ cord-252871-qfrpuy3t 115 26 proteins protein NNS cord-252871-qfrpuy3t 115 27 to to TO cord-252871-qfrpuy3t 115 28 function function VB cord-252871-qfrpuy3t 115 29 as as IN cord-252871-qfrpuy3t 115 30 virus virus NN cord-252871-qfrpuy3t 115 31 capsids capsid NNS cord-252871-qfrpuy3t 115 32 once once IN cord-252871-qfrpuy3t 115 33 cells cell NNS cord-252871-qfrpuy3t 115 34 appeared appear VBD cord-252871-qfrpuy3t 115 35 in in IN cord-252871-qfrpuy3t 115 36 evolution evolution NN cord-252871-qfrpuy3t 115 37 . . . cord-252871-qfrpuy3t 116 1 In in IN cord-252871-qfrpuy3t 116 2 their -PRON- PRP$ cord-252871-qfrpuy3t 116 3 view view NN cord-252871-qfrpuy3t 116 4 , , , cord-252871-qfrpuy3t 116 5 giant giant JJ cord-252871-qfrpuy3t 116 6 viruses virus NNS cord-252871-qfrpuy3t 116 7 such such JJ cord-252871-qfrpuy3t 116 8 as as IN cord-252871-qfrpuy3t 116 9 pandoraviruses pandoraviruse NNS cord-252871-qfrpuy3t 116 10 and and CC cord-252871-qfrpuy3t 116 11 Mimiviruses Mimiviruses NNPS cord-252871-qfrpuy3t 116 12 gradually gradually RB cord-252871-qfrpuy3t 116 13 became become VBD cord-252871-qfrpuy3t 116 14 bigger big JJR cord-252871-qfrpuy3t 116 15 due due IN cord-252871-qfrpuy3t 116 16 to to IN cord-252871-qfrpuy3t 116 17 frequent frequent JJ cord-252871-qfrpuy3t 116 18 gene gene NN cord-252871-qfrpuy3t 116 19 capture capture NN cord-252871-qfrpuy3t 116 20 from from IN cord-252871-qfrpuy3t 116 21 host host NN cord-252871-qfrpuy3t 116 22 cells cell NNS cord-252871-qfrpuy3t 116 23 [ [ -LRB- cord-252871-qfrpuy3t 116 24 46 46 CD cord-252871-qfrpuy3t 116 25 ] ] -RRB- cord-252871-qfrpuy3t 116 26 . . . cord-252871-qfrpuy3t 117 1 Their -PRON- PRP$ cord-252871-qfrpuy3t 117 2 model model NN cord-252871-qfrpuy3t 117 3 thus thus RB cord-252871-qfrpuy3t 117 4 explains explain VBZ cord-252871-qfrpuy3t 117 5 the the DT cord-252871-qfrpuy3t 117 6 massive massive JJ cord-252871-qfrpuy3t 117 7 genetic genetic JJ cord-252871-qfrpuy3t 117 8 diversity diversity NN cord-252871-qfrpuy3t 117 9 seen see VBN cord-252871-qfrpuy3t 117 10 in in IN cord-252871-qfrpuy3t 117 11 virus virus NN cord-252871-qfrpuy3t 117 12 replicons replicon NNS cord-252871-qfrpuy3t 117 13 and and CC cord-252871-qfrpuy3t 117 14 proposes propose VBZ cord-252871-qfrpuy3t 117 15 mechanisms mechanism NNS cord-252871-qfrpuy3t 117 16 for for IN cord-252871-qfrpuy3t 117 17 the the DT cord-252871-qfrpuy3t 117 18 origin origin NN cord-252871-qfrpuy3t 117 19 of of IN cord-252871-qfrpuy3t 117 20 virus virus NNP cord-252871-qfrpuy3t 117 21 capsids capsid NNS cord-252871-qfrpuy3t 117 22 and and CC cord-252871-qfrpuy3t 117 23 giant giant JJ cord-252871-qfrpuy3t 117 24 viruses virus NNS cord-252871-qfrpuy3t 117 25 . . . cord-252871-qfrpuy3t 118 1 We -PRON- PRP cord-252871-qfrpuy3t 118 2 disagree disagree VBP cord-252871-qfrpuy3t 118 3 with with IN cord-252871-qfrpuy3t 118 4 the the DT cord-252871-qfrpuy3t 118 5 model model NN cord-252871-qfrpuy3t 118 6 on on IN cord-252871-qfrpuy3t 118 7 two two CD cord-252871-qfrpuy3t 118 8 major major JJ cord-252871-qfrpuy3t 118 9 points point NNS cord-252871-qfrpuy3t 118 10 . . . cord-252871-qfrpuy3t 119 1 First first RB cord-252871-qfrpuy3t 119 2 , , , cord-252871-qfrpuy3t 119 3 it -PRON- PRP cord-252871-qfrpuy3t 119 4 is be VBZ cord-252871-qfrpuy3t 119 5 unnecessary unnecessary JJ cord-252871-qfrpuy3t 119 6 to to TO cord-252871-qfrpuy3t 119 7 invoke invoke VB cord-252871-qfrpuy3t 119 8 a a DT cord-252871-qfrpuy3t 119 9 pre pre JJ cord-252871-qfrpuy3t 119 10 - - JJ cord-252871-qfrpuy3t 119 11 cellular cellular JJ cord-252871-qfrpuy3t 119 12 world world NN cord-252871-qfrpuy3t 119 13 to to TO cord-252871-qfrpuy3t 119 14 explain explain VB cord-252871-qfrpuy3t 119 15 the the DT cord-252871-qfrpuy3t 119 16 observed observed JJ cord-252871-qfrpuy3t 119 17 replicon replicon NN cord-252871-qfrpuy3t 119 18 and and CC cord-252871-qfrpuy3t 119 19 genetic genetic JJ cord-252871-qfrpuy3t 119 20 diversity diversity NN cord-252871-qfrpuy3t 119 21 among among IN cord-252871-qfrpuy3t 119 22 modern modern JJ cord-252871-qfrpuy3t 119 23 - - HYPH cord-252871-qfrpuy3t 119 24 day day NN cord-252871-qfrpuy3t 119 25 viruses virus NNS cord-252871-qfrpuy3t 119 26 . . . cord-252871-qfrpuy3t 120 1 This this DT cord-252871-qfrpuy3t 120 2 diversity diversity NN cord-252871-qfrpuy3t 120 3 can can MD cord-252871-qfrpuy3t 120 4 simply simply RB cord-252871-qfrpuy3t 120 5 unfold unfold VB cord-252871-qfrpuy3t 120 6 in in IN cord-252871-qfrpuy3t 120 7 the the DT cord-252871-qfrpuy3t 120 8 pool pool NN cord-252871-qfrpuy3t 120 9 of of IN cord-252871-qfrpuy3t 120 10 ancient ancient JJ cord-252871-qfrpuy3t 120 11 cells cell NNS cord-252871-qfrpuy3t 120 12 that that WDT cord-252871-qfrpuy3t 120 13 existed exist VBD cord-252871-qfrpuy3t 120 14 prior prior RB cord-252871-qfrpuy3t 120 15 to to IN cord-252871-qfrpuy3t 120 16 LUCA LUCA NNP cord-252871-qfrpuy3t 120 17 . . . cord-252871-qfrpuy3t 121 1 Second second RB cord-252871-qfrpuy3t 121 2 , , , cord-252871-qfrpuy3t 121 3 the the DT cord-252871-qfrpuy3t 121 4 proposed propose VBN cord-252871-qfrpuy3t 121 5 incremental incremental JJ cord-252871-qfrpuy3t 121 6 growth growth NN cord-252871-qfrpuy3t 121 7 of of IN cord-252871-qfrpuy3t 121 8 viral viral JJ cord-252871-qfrpuy3t 121 9 genomes genome NNS cord-252871-qfrpuy3t 121 10 , , , cord-252871-qfrpuy3t 121 11 especially especially RB cord-252871-qfrpuy3t 121 12 large large JJ cord-252871-qfrpuy3t 121 13 DNA dna NN cord-252871-qfrpuy3t 121 14 viruses virus NNS cord-252871-qfrpuy3t 121 15 , , , cord-252871-qfrpuy3t 121 16 via via IN cord-252871-qfrpuy3t 121 17 gene gene NN cord-252871-qfrpuy3t 121 18 gain gain NN cord-252871-qfrpuy3t 121 19 from from IN cord-252871-qfrpuy3t 121 20 hosts host NNS cord-252871-qfrpuy3t 121 21 is be VBZ cord-252871-qfrpuy3t 121 22 incompatible incompatible JJ cord-252871-qfrpuy3t 121 23 with with IN cord-252871-qfrpuy3t 121 24 our -PRON- PRP$ cord-252871-qfrpuy3t 121 25 knowledge knowledge NN cord-252871-qfrpuy3t 121 26 of of IN cord-252871-qfrpuy3t 121 27 how how WRB cord-252871-qfrpuy3t 121 28 endosymbiotic endosymbiotic JJ cord-252871-qfrpuy3t 121 29 / / SYM cord-252871-qfrpuy3t 121 30 parasitic parasitic JJ cord-252871-qfrpuy3t 121 31 cells cell NNS cord-252871-qfrpuy3t 121 32 evolve evolve VBP cord-252871-qfrpuy3t 121 33 . . . cord-252871-qfrpuy3t 122 1 Cells cell NNS cord-252871-qfrpuy3t 122 2 committed commit VBN cord-252871-qfrpuy3t 122 3 to to TO cord-252871-qfrpuy3t 122 4 obligate obligate VB cord-252871-qfrpuy3t 122 5 parasitism parasitism NN cord-252871-qfrpuy3t 122 6 are be VBP cord-252871-qfrpuy3t 122 7 characterized characterize VBN cord-252871-qfrpuy3t 122 8 by by IN cord-252871-qfrpuy3t 122 9 extreme extreme JJ cord-252871-qfrpuy3t 122 10 genomic genomic JJ cord-252871-qfrpuy3t 122 11 and and CC cord-252871-qfrpuy3t 122 12 physical physical JJ cord-252871-qfrpuy3t 122 13 reduction reduction NN cord-252871-qfrpuy3t 122 14 as as IN cord-252871-qfrpuy3t 122 15 they -PRON- PRP cord-252871-qfrpuy3t 122 16 increase increase VBP cord-252871-qfrpuy3t 122 17 dependency dependency NN cord-252871-qfrpuy3t 122 18 on on IN cord-252871-qfrpuy3t 122 19 their -PRON- PRP$ cord-252871-qfrpuy3t 122 20 hosts host NNS cord-252871-qfrpuy3t 122 21 [ [ -LRB- cord-252871-qfrpuy3t 122 22 26 26 CD cord-252871-qfrpuy3t 122 23 , , , cord-252871-qfrpuy3t 122 24 47 47 CD cord-252871-qfrpuy3t 122 25 ] ] -RRB- cord-252871-qfrpuy3t 122 26 . . . cord-252871-qfrpuy3t 123 1 It -PRON- PRP cord-252871-qfrpuy3t 123 2 makes make VBZ cord-252871-qfrpuy3t 123 3 sense sense NN cord-252871-qfrpuy3t 123 4 to to TO cord-252871-qfrpuy3t 123 5 think think VB cord-252871-qfrpuy3t 123 6 that that IN cord-252871-qfrpuy3t 123 7 viruses virus NNS cord-252871-qfrpuy3t 123 8 , , , cord-252871-qfrpuy3t 123 9 which which WDT cord-252871-qfrpuy3t 123 10 are be VBP cord-252871-qfrpuy3t 123 11 the the DT cord-252871-qfrpuy3t 123 12 ultimate ultimate JJ cord-252871-qfrpuy3t 123 13 examples example NNS cord-252871-qfrpuy3t 123 14 of of IN cord-252871-qfrpuy3t 123 15 parasitism parasitism NN cord-252871-qfrpuy3t 123 16 , , , cord-252871-qfrpuy3t 123 17 would would MD cord-252871-qfrpuy3t 123 18 also also RB cord-252871-qfrpuy3t 123 19 evolve evolve VB cord-252871-qfrpuy3t 123 20 similarly similarly RB cord-252871-qfrpuy3t 123 21 . . . cord-252871-qfrpuy3t 124 1 This this DT cord-252871-qfrpuy3t 124 2 ' ' `` cord-252871-qfrpuy3t 124 3 reduction reduction NN cord-252871-qfrpuy3t 124 4 ' ' '' cord-252871-qfrpuy3t 124 5 scenario scenario NN cord-252871-qfrpuy3t 124 6 is be VBZ cord-252871-qfrpuy3t 124 7 more more RBR cord-252871-qfrpuy3t 124 8 parsimonious parsimonious JJ cord-252871-qfrpuy3t 124 9 when when WRB cord-252871-qfrpuy3t 124 10 one one PRP cord-252871-qfrpuy3t 124 11 considers consider VBZ cord-252871-qfrpuy3t 124 12 the the DT cord-252871-qfrpuy3t 124 13 gigantic gigantic JJ cord-252871-qfrpuy3t 124 14 genome genome NN cord-252871-qfrpuy3t 124 15 sizes size NNS cord-252871-qfrpuy3t 124 16 of of IN cord-252871-qfrpuy3t 124 17 pandoraviruses pandoraviruse NNS cord-252871-qfrpuy3t 124 18 ( ( -LRB- cord-252871-qfrpuy3t 124 19 ~2500 ~2500 CD cord-252871-qfrpuy3t 124 20 genes gene NNS cord-252871-qfrpuy3t 124 21 ) ) -RRB- cord-252871-qfrpuy3t 124 22 . . . cord-252871-qfrpuy3t 125 1 There there EX cord-252871-qfrpuy3t 125 2 is be VBZ cord-252871-qfrpuy3t 125 3 no no DT cord-252871-qfrpuy3t 125 4 clear clear JJ cord-252871-qfrpuy3t 125 5 incentive incentive NN cord-252871-qfrpuy3t 125 6 as as IN cord-252871-qfrpuy3t 125 7 to to IN cord-252871-qfrpuy3t 125 8 why why WRB cord-252871-qfrpuy3t 125 9 a a DT cord-252871-qfrpuy3t 125 10 small small JJ cord-252871-qfrpuy3t 125 11 - - HYPH cord-252871-qfrpuy3t 125 12 sized sized JJ cord-252871-qfrpuy3t 125 13 virus virus NN cord-252871-qfrpuy3t 125 14 genome genome NN cord-252871-qfrpuy3t 125 15 ( ( -LRB- cord-252871-qfrpuy3t 125 16 ~5 ~5 NNP cord-252871-qfrpuy3t 125 17 genes gene NNS cord-252871-qfrpuy3t 125 18 in in IN cord-252871-qfrpuy3t 125 19 papillomaviruses papillomaviruse NNS cord-252871-qfrpuy3t 125 20 ) ) -RRB- cord-252871-qfrpuy3t 125 21 would would MD cord-252871-qfrpuy3t 125 22 adopt adopt VB cord-252871-qfrpuy3t 125 23 a a DT cord-252871-qfrpuy3t 125 24 scenario scenario NN cord-252871-qfrpuy3t 125 25 is be VBZ cord-252871-qfrpuy3t 125 26 incompatible incompatible JJ cord-252871-qfrpuy3t 125 27 with with IN cord-252871-qfrpuy3t 125 28 the the DT cord-252871-qfrpuy3t 125 29 proposed propose VBN cord-252871-qfrpuy3t 125 30 generic generic JJ cord-252871-qfrpuy3t 125 31 definition definition NN cord-252871-qfrpuy3t 125 32 of of IN cord-252871-qfrpuy3t 125 33 virus virus NN cord-252871-qfrpuy3t 125 34 propagation propagation NN cord-252871-qfrpuy3t 125 35 inside inside IN cord-252871-qfrpuy3t 125 36 cells cell NNS cord-252871-qfrpuy3t 125 37 . . . cord-252871-qfrpuy3t 126 1 In in IN cord-252871-qfrpuy3t 126 2 turn turn NN cord-252871-qfrpuy3t 126 3 , , , cord-252871-qfrpuy3t 126 4 the the DT cord-252871-qfrpuy3t 126 5 origin origin NN cord-252871-qfrpuy3t 126 6 of of IN cord-252871-qfrpuy3t 126 7 archaeoviruses archaeoviruse NNS cord-252871-qfrpuy3t 126 8 from from IN cord-252871-qfrpuy3t 126 9 Archaea Archaea NNP cord-252871-qfrpuy3t 126 10 , , , cord-252871-qfrpuy3t 126 11 bacterioviruses bacterioviruse NNS cord-252871-qfrpuy3t 126 12 from from IN cord-252871-qfrpuy3t 126 13 Bacteria Bacteria NNS cord-252871-qfrpuy3t 126 14 , , , cord-252871-qfrpuy3t 126 15 and and CC cord-252871-qfrpuy3t 126 16 eukaryoviruses eukaryoviruse NNS cord-252871-qfrpuy3t 126 17 from from IN cord-252871-qfrpuy3t 126 18 Eukarya Eukarya NNP cord-252871-qfrpuy3t 126 19 also also RB cord-252871-qfrpuy3t 126 20 seems seem VBZ cord-252871-qfrpuy3t 126 21 less less RBR cord-252871-qfrpuy3t 126 22 likely likely JJ cord-252871-qfrpuy3t 126 23 as as IN cord-252871-qfrpuy3t 126 24 these these DT cord-252871-qfrpuy3t 126 25 viruses virus NNS cord-252871-qfrpuy3t 126 26 share share VBP cord-252871-qfrpuy3t 126 27 several several JJ cord-252871-qfrpuy3t 126 28 conserved conserve VBN cord-252871-qfrpuy3t 126 29 protein protein NN cord-252871-qfrpuy3t 126 30 folds fold NNS cord-252871-qfrpuy3t 126 31 involved involve VBN cord-252871-qfrpuy3t 126 32 in in IN cord-252871-qfrpuy3t 126 33 virion virion NN cord-252871-qfrpuy3t 126 34 synthesis synthesis NN cord-252871-qfrpuy3t 126 35 and and CC cord-252871-qfrpuy3t 126 36 other other JJ cord-252871-qfrpuy3t 126 37 functions function NNS cord-252871-qfrpuy3t 126 38 , , , cord-252871-qfrpuy3t 126 39 indicating indicate VBG cord-252871-qfrpuy3t 126 40 that that IN cord-252871-qfrpuy3t 126 41 they -PRON- PRP cord-252871-qfrpuy3t 126 42 may may MD cord-252871-qfrpuy3t 126 43 have have VB cord-252871-qfrpuy3t 126 44 evolved evolve VBN cord-252871-qfrpuy3t 126 45 prior prior RB cord-252871-qfrpuy3t 126 46 to to IN cord-252871-qfrpuy3t 126 47 the the DT cord-252871-qfrpuy3t 126 48 diversification diversification NN cord-252871-qfrpuy3t 126 49 of of IN cord-252871-qfrpuy3t 126 50 LUCA LUCA NNP cord-252871-qfrpuy3t 126 51 into into IN cord-252871-qfrpuy3t 126 52 modern modern JJ cord-252871-qfrpuy3t 126 53 cells cell NNS cord-252871-qfrpuy3t 126 54 . . . cord-252871-qfrpuy3t 127 1 These these DT cord-252871-qfrpuy3t 127 2 considerations consideration NNS cord-252871-qfrpuy3t 127 3 support support VBP cord-252871-qfrpuy3t 127 4 an an DT cord-252871-qfrpuy3t 127 5 intermediate intermediate JJ cord-252871-qfrpuy3t 127 6 timing timing NN cord-252871-qfrpuy3t 127 7 for for IN cord-252871-qfrpuy3t 127 8 the the DT cord-252871-qfrpuy3t 127 9 origin origin NN cord-252871-qfrpuy3t 127 10 of of IN cord-252871-qfrpuy3t 127 11 viruses virus NNS cord-252871-qfrpuy3t 127 12 , , , cord-252871-qfrpuy3t 127 13 that that RB cord-252871-qfrpuy3t 127 14 is is RB cord-252871-qfrpuy3t 127 15 , , , cord-252871-qfrpuy3t 127 16 from from IN cord-252871-qfrpuy3t 127 17 ancient ancient JJ cord-252871-qfrpuy3t 127 18 cells cell NNS cord-252871-qfrpuy3t 127 19 that that WDT cord-252871-qfrpuy3t 127 20 existed exist VBD cord-252871-qfrpuy3t 127 21 prior prior RB cord-252871-qfrpuy3t 127 22 to to IN cord-252871-qfrpuy3t 127 23 LUCA LUCA NNP cord-252871-qfrpuy3t 127 24 . . . cord-252871-qfrpuy3t 128 1 Modified modify VBN cord-252871-qfrpuy3t 128 2 from from IN cord-252871-qfrpuy3t 128 3 [ [ -LRB- cord-252871-qfrpuy3t 128 4 82 82 CD cord-252871-qfrpuy3t 128 5 ] ] -RRB- cord-252871-qfrpuy3t 128 6 . . . cord-252871-qfrpuy3t 129 1 Abbreviation abbreviation NN cord-252871-qfrpuy3t 129 2 : : : cord-252871-qfrpuy3t 129 3 LUCA LUCA NNP cord-252871-qfrpuy3t 129 4 , , , cord-252871-qfrpuy3t 129 5 last last JJ cord-252871-qfrpuy3t 129 6 universal universal JJ cord-252871-qfrpuy3t 129 7 common common JJ cord-252871-qfrpuy3t 129 8 ancestor ancestor NN cord-252871-qfrpuy3t 129 9 . . . cord-252871-qfrpuy3t 130 1 pathway pathway NN cord-252871-qfrpuy3t 130 2 towards towards IN cord-252871-qfrpuy3t 130 3 gigantism gigantism NN cord-252871-qfrpuy3t 130 4 , , , cord-252871-qfrpuy3t 130 5 when when WRB cord-252871-qfrpuy3t 130 6 it -PRON- PRP cord-252871-qfrpuy3t 130 7 is be VBZ cord-252871-qfrpuy3t 130 8 already already RB cord-252871-qfrpuy3t 130 9 a a DT cord-252871-qfrpuy3t 130 10 well well RB cord-252871-qfrpuy3t 130 11 - - HYPH cord-252871-qfrpuy3t 130 12 established establish VBN cord-252871-qfrpuy3t 130 13 parasite parasite NN cord-252871-qfrpuy3t 130 14 . . . cord-252871-qfrpuy3t 131 1 Moreover moreover RB cord-252871-qfrpuy3t 131 2 , , , cord-252871-qfrpuy3t 131 3 regular regular JJ cord-252871-qfrpuy3t 131 4 and and CC cord-252871-qfrpuy3t 131 5 recent recent JJ cord-252871-qfrpuy3t 131 6 gene gene NN cord-252871-qfrpuy3t 131 7 uptake uptake NN cord-252871-qfrpuy3t 131 8 from from IN cord-252871-qfrpuy3t 131 9 cells cell NNS cord-252871-qfrpuy3t 131 10 is be VBZ cord-252871-qfrpuy3t 131 11 expected expect VBN cord-252871-qfrpuy3t 131 12 to to TO cord-252871-qfrpuy3t 131 13 leave leave VB cord-252871-qfrpuy3t 131 14 detectable detectable JJ cord-252871-qfrpuy3t 131 15 similarity similarity NN cord-252871-qfrpuy3t 131 16 traces trace NNS cord-252871-qfrpuy3t 131 17 in in IN cord-252871-qfrpuy3t 131 18 the the DT cord-252871-qfrpuy3t 131 19 viral viral JJ cord-252871-qfrpuy3t 131 20 genomes genome NNS cord-252871-qfrpuy3t 131 21 . . . cord-252871-qfrpuy3t 132 1 However however RB cord-252871-qfrpuy3t 132 2 , , , cord-252871-qfrpuy3t 132 3 > > XX cord-252871-qfrpuy3t 132 4 90 90 CD cord-252871-qfrpuy3t 132 5 % % NN cord-252871-qfrpuy3t 132 6 of of IN cord-252871-qfrpuy3t 132 7 Pandoravirus Pandoravirus NNP cord-252871-qfrpuy3t 132 8 genes gene NNS cord-252871-qfrpuy3t 132 9 show show VBP cord-252871-qfrpuy3t 132 10 no no DT cord-252871-qfrpuy3t 132 11 similarity similarity NN cord-252871-qfrpuy3t 132 12 to to IN cord-252871-qfrpuy3t 132 13 cellular cellular JJ cord-252871-qfrpuy3t 132 14 genes gene NNS cord-252871-qfrpuy3t 132 15 [ [ -LRB- cord-252871-qfrpuy3t 132 16 24 24 CD cord-252871-qfrpuy3t 132 17 ] ] -RRB- cord-252871-qfrpuy3t 132 18 ( ( -LRB- cord-252871-qfrpuy3t 132 19 a a DT cord-252871-qfrpuy3t 132 20 feature feature NN cord-252871-qfrpuy3t 132 21 conserved conserve VBN cord-252871-qfrpuy3t 132 22 in in IN cord-252871-qfrpuy3t 132 23 many many JJ cord-252871-qfrpuy3t 132 24 viruses virus NNS cord-252871-qfrpuy3t 132 25 [ [ -LRB- cord-252871-qfrpuy3t 132 26 41 41 CD cord-252871-qfrpuy3t 132 27 ] ] -RRB- cord-252871-qfrpuy3t 132 28 , , , cord-252871-qfrpuy3t 132 29 see see VB cord-252871-qfrpuy3t 132 30 also also RB cord-252871-qfrpuy3t 132 31 [ [ -LRB- cord-252871-qfrpuy3t 132 32 48 48 CD cord-252871-qfrpuy3t 132 33 ] ] -RRB- cord-252871-qfrpuy3t 132 34 ) ) -RRB- cord-252871-qfrpuy3t 132 35 and and CC cord-252871-qfrpuy3t 132 36 viruses virus NNS cord-252871-qfrpuy3t 132 37 encode encode VBP cord-252871-qfrpuy3t 132 38 several several JJ cord-252871-qfrpuy3t 132 39 protein protein NN cord-252871-qfrpuy3t 132 40 fold fold NN cord-252871-qfrpuy3t 132 41 structures structure NNS cord-252871-qfrpuy3t 132 42 that that WDT cord-252871-qfrpuy3t 132 43 have have VBP cord-252871-qfrpuy3t 132 44 never never RB cord-252871-qfrpuy3t 132 45 been be VBN cord-252871-qfrpuy3t 132 46 detected detect VBN cord-252871-qfrpuy3t 132 47 in in IN cord-252871-qfrpuy3t 132 48 cells cell NNS cord-252871-qfrpuy3t 132 49 [ [ -LRB- cord-252871-qfrpuy3t 132 50 41 41 CD cord-252871-qfrpuy3t 132 51 ] ] -RRB- cord-252871-qfrpuy3t 132 52 . . . cord-252871-qfrpuy3t 133 1 It -PRON- PRP cord-252871-qfrpuy3t 133 2 is be VBZ cord-252871-qfrpuy3t 133 3 strange strange JJ cord-252871-qfrpuy3t 133 4 to to TO cord-252871-qfrpuy3t 133 5 think think VB cord-252871-qfrpuy3t 133 6 that that IN cord-252871-qfrpuy3t 133 7 regularly regularly RB cord-252871-qfrpuy3t 133 8 and and CC cord-252871-qfrpuy3t 133 9 recently recently RB cord-252871-qfrpuy3t 133 10 captured capture VBD cord-252871-qfrpuy3t 133 11 viral viral JJ cord-252871-qfrpuy3t 133 12 genes gene NNS cord-252871-qfrpuy3t 133 13 are be VBP cord-252871-qfrpuy3t 133 14 no no RB cord-252871-qfrpuy3t 133 15 longer long RBR cord-252871-qfrpuy3t 133 16 recognizable recognizable JJ cord-252871-qfrpuy3t 133 17 whereas whereas IN cord-252871-qfrpuy3t 133 18 presumably presumably RB cord-252871-qfrpuy3t 133 19 ancient ancient JJ cord-252871-qfrpuy3t 133 20 ' ' `` cord-252871-qfrpuy3t 133 21 core core NN cord-252871-qfrpuy3t 133 22 ' ' '' cord-252871-qfrpuy3t 133 23 genes gene NNS cord-252871-qfrpuy3t 133 24 used use VBN cord-252871-qfrpuy3t 133 25 to to TO cord-252871-qfrpuy3t 133 26 build build VB cord-252871-qfrpuy3t 133 27 virus virus NN cord-252871-qfrpuy3t 133 28 phylogenies phylogeny NNS cord-252871-qfrpuy3t 133 29 are be VBP cord-252871-qfrpuy3t 133 30 readily readily RB cord-252871-qfrpuy3t 133 31 recognizable recognizable JJ cord-252871-qfrpuy3t 133 32 . . . cord-252871-qfrpuy3t 134 1 Surprisingly surprisingly RB cord-252871-qfrpuy3t 134 2 , , , cord-252871-qfrpuy3t 134 3 the the DT cord-252871-qfrpuy3t 134 4 existence existence NN cord-252871-qfrpuy3t 134 5 and and CC cord-252871-qfrpuy3t 134 6 abundance abundance NN cord-252871-qfrpuy3t 134 7 of of IN cord-252871-qfrpuy3t 134 8 virus virus NN cord-252871-qfrpuy3t 134 9 - - HYPH cord-252871-qfrpuy3t 134 10 specific specific JJ cord-252871-qfrpuy3t 134 11 genes gene NNS cord-252871-qfrpuy3t 134 12 ( ( -LRB- cord-252871-qfrpuy3t 134 13 i.e. i.e. FW cord-252871-qfrpuy3t 134 14 , , , cord-252871-qfrpuy3t 134 15 genes gene NNS cord-252871-qfrpuy3t 134 16 or or CC cord-252871-qfrpuy3t 134 17 protein protein NN cord-252871-qfrpuy3t 134 18 folds fold NNS cord-252871-qfrpuy3t 134 19 detected detect VBN cord-252871-qfrpuy3t 134 20 only only RB cord-252871-qfrpuy3t 134 21 in in IN cord-252871-qfrpuy3t 134 22 viral viral JJ cord-252871-qfrpuy3t 134 23 genomes genome NNS cord-252871-qfrpuy3t 134 24 ) ) -RRB- cord-252871-qfrpuy3t 134 25 are be VBP cord-252871-qfrpuy3t 134 26 rarely rarely RB cord-252871-qfrpuy3t 134 27 discussed discuss VBN cord-252871-qfrpuy3t 134 28 in in IN cord-252871-qfrpuy3t 134 29 the the DT cord-252871-qfrpuy3t 134 30 models model NNS cord-252871-qfrpuy3t 134 31 of of IN cord-252871-qfrpuy3t 134 32 virus virus NN cord-252871-qfrpuy3t 134 33 origin origin NN cord-252871-qfrpuy3t 134 34 and and CC cord-252871-qfrpuy3t 134 35 evolution evolution NN cord-252871-qfrpuy3t 134 36 . . . cord-252871-qfrpuy3t 135 1 Instead instead RB cord-252871-qfrpuy3t 135 2 , , , cord-252871-qfrpuy3t 135 3 homology homology NN cord-252871-qfrpuy3t 135 4 of of IN cord-252871-qfrpuy3t 135 5 a a DT cord-252871-qfrpuy3t 135 6 subset subset NN cord-252871-qfrpuy3t 135 7 of of IN cord-252871-qfrpuy3t 135 8 ' ' `` cord-252871-qfrpuy3t 135 9 core core NN cord-252871-qfrpuy3t 135 10 ' ' '' cord-252871-qfrpuy3t 135 11 virus virus NN cord-252871-qfrpuy3t 135 12 genes gene NNS cord-252871-qfrpuy3t 135 13 to to IN cord-252871-qfrpuy3t 135 14 their -PRON- PRP$ cord-252871-qfrpuy3t 135 15 cellular cellular JJ cord-252871-qfrpuy3t 135 16 counterparts counterpart NNS cord-252871-qfrpuy3t 135 17 is be VBZ cord-252871-qfrpuy3t 135 18 used use VBN cord-252871-qfrpuy3t 135 19 to to TO cord-252871-qfrpuy3t 135 20 generalize generalize VB cord-252871-qfrpuy3t 135 21 the the DT cord-252871-qfrpuy3t 135 22 notion notion NN cord-252871-qfrpuy3t 135 23 that that IN cord-252871-qfrpuy3t 135 24 viruses virus NNS cord-252871-qfrpuy3t 135 25 evolve evolve VBP cord-252871-qfrpuy3t 135 26 by by IN cord-252871-qfrpuy3t 135 27 acquiring acquire VBG cord-252871-qfrpuy3t 135 28 cellular cellular JJ cord-252871-qfrpuy3t 135 29 genes gene NNS cord-252871-qfrpuy3t 135 30 [ [ -LRB- cord-252871-qfrpuy3t 135 31 49 49 CD cord-252871-qfrpuy3t 135 32 ] ] -RRB- cord-252871-qfrpuy3t 135 33 . . . cord-252871-qfrpuy3t 136 1 This this DT cord-252871-qfrpuy3t 136 2 practice practice NN cord-252871-qfrpuy3t 136 3 yields yield VBZ cord-252871-qfrpuy3t 136 4 an an DT cord-252871-qfrpuy3t 136 5 incomplete incomplete JJ cord-252871-qfrpuy3t 136 6 view view NN cord-252871-qfrpuy3t 136 7 of of IN cord-252871-qfrpuy3t 136 8 the the DT cord-252871-qfrpuy3t 136 9 composition composition NN cord-252871-qfrpuy3t 136 10 and and CC cord-252871-qfrpuy3t 136 11 evolution evolution NN cord-252871-qfrpuy3t 136 12 of of IN cord-252871-qfrpuy3t 136 13 virus virus NN cord-252871-qfrpuy3t 136 14 genomes genome NNS cord-252871-qfrpuy3t 136 15 and and CC cord-252871-qfrpuy3t 136 16 ignores ignore VBZ cord-252871-qfrpuy3t 136 17 the the DT cord-252871-qfrpuy3t 136 18 significant significant JJ cord-252871-qfrpuy3t 136 19 de de FW cord-252871-qfrpuy3t 136 20 novo novo NNP cord-252871-qfrpuy3t 136 21 gene gene NN cord-252871-qfrpuy3t 136 22 creation creation NN cord-252871-qfrpuy3t 136 23 abilities ability NNS cord-252871-qfrpuy3t 136 24 in in IN cord-252871-qfrpuy3t 136 25 viruses virus NNS cord-252871-qfrpuy3t 136 26 , , , cord-252871-qfrpuy3t 136 27 especially especially RB cord-252871-qfrpuy3t 136 28 in in IN cord-252871-qfrpuy3t 136 29 pandoraviruses pandoraviruse NNS cord-252871-qfrpuy3t 136 30 [ [ -LRB- cord-252871-qfrpuy3t 136 31 42 42 CD cord-252871-qfrpuy3t 136 32 ] ] -RRB- cord-252871-qfrpuy3t 136 33 . . . cord-252871-qfrpuy3t 137 1 Moreover moreover RB cord-252871-qfrpuy3t 137 2 , , , cord-252871-qfrpuy3t 137 3 ' ' `` cord-252871-qfrpuy3t 137 4 core core NN cord-252871-qfrpuy3t 137 5 ' ' '' cord-252871-qfrpuy3t 137 6 genes gene NNS cord-252871-qfrpuy3t 137 7 describe describe VBP cord-252871-qfrpuy3t 137 8 the the DT cord-252871-qfrpuy3t 137 9 evolutionary evolutionary JJ cord-252871-qfrpuy3t 137 10 histories history NNS cord-252871-qfrpuy3t 137 11 of of IN cord-252871-qfrpuy3t 137 12 individual individual JJ cord-252871-qfrpuy3t 137 13 genes gene NNS cord-252871-qfrpuy3t 137 14 and and CC cord-252871-qfrpuy3t 137 15 not not RB cord-252871-qfrpuy3t 137 16 the the DT cord-252871-qfrpuy3t 137 17 whole whole JJ cord-252871-qfrpuy3t 137 18 organisms organism NNS cord-252871-qfrpuy3t 137 19 . . . cord-252871-qfrpuy3t 138 1 They -PRON- PRP cord-252871-qfrpuy3t 138 2 can can MD cord-252871-qfrpuy3t 138 3 be be VB cord-252871-qfrpuy3t 138 4 patchily patchily RB cord-252871-qfrpuy3t 138 5 distributed distribute VBN cord-252871-qfrpuy3t 138 6 , , , cord-252871-qfrpuy3t 138 7 similar similar JJ cord-252871-qfrpuy3t 138 8 to to IN cord-252871-qfrpuy3t 138 9 virus virus NN cord-252871-qfrpuy3t 138 10 - - HYPH cord-252871-qfrpuy3t 138 11 specific specific JJ cord-252871-qfrpuy3t 138 12 genes gene NNS cord-252871-qfrpuy3t 138 13 , , , cord-252871-qfrpuy3t 138 14 and and CC cord-252871-qfrpuy3t 138 15 the the DT cord-252871-qfrpuy3t 138 16 number number NN cord-252871-qfrpuy3t 138 17 of of IN cord-252871-qfrpuy3t 138 18 available available JJ cord-252871-qfrpuy3t 138 19 core core NN cord-252871-qfrpuy3t 138 20 genes gene NNS cord-252871-qfrpuy3t 138 21 for for IN cord-252871-qfrpuy3t 138 22 phylogenetic phylogenetic JJ cord-252871-qfrpuy3t 138 23 studies study NNS cord-252871-qfrpuy3t 138 24 is be VBZ cord-252871-qfrpuy3t 138 25 strongly strongly RB cord-252871-qfrpuy3t 138 26 dependent dependent JJ cord-252871-qfrpuy3t 138 27 on on IN cord-252871-qfrpuy3t 138 28 the the DT cord-252871-qfrpuy3t 138 29 number number NN cord-252871-qfrpuy3t 138 30 of of IN cord-252871-qfrpuy3t 138 31 sampled sample VBN cord-252871-qfrpuy3t 138 32 genomes genome NNS cord-252871-qfrpuy3t 138 33 and and CC cord-252871-qfrpuy3t 138 34 their -PRON- PRP$ cord-252871-qfrpuy3t 138 35 taxonomic taxonomic JJ cord-252871-qfrpuy3t 138 36 range range NN cord-252871-qfrpuy3t 138 37 [ [ -LRB- cord-252871-qfrpuy3t 138 38 50 50 CD cord-252871-qfrpuy3t 138 39 ] ] -RRB- cord-252871-qfrpuy3t 138 40 . . . cord-252871-qfrpuy3t 139 1 For for IN cord-252871-qfrpuy3t 139 2 example example NN cord-252871-qfrpuy3t 139 3 , , , cord-252871-qfrpuy3t 139 4 no no DT cord-252871-qfrpuy3t 139 5 single single JJ cord-252871-qfrpuy3t 139 6 gene gene NN cord-252871-qfrpuy3t 139 7 or or CC cord-252871-qfrpuy3t 139 8 protein protein NN cord-252871-qfrpuy3t 139 9 fold fold NN cord-252871-qfrpuy3t 139 10 is be VBZ cord-252871-qfrpuy3t 139 11 conserved conserve VBN cord-252871-qfrpuy3t 139 12 across across IN cord-252871-qfrpuy3t 139 13 all all DT cord-252871-qfrpuy3t 139 14 RNA RNA NNP cord-252871-qfrpuy3t 139 15 and and CC cord-252871-qfrpuy3t 139 16 DNA dna NN cord-252871-qfrpuy3t 139 17 viruses virus NNS cord-252871-qfrpuy3t 139 18 and and CC cord-252871-qfrpuy3t 139 19 very very RB cord-252871-qfrpuy3t 139 20 few few JJ cord-252871-qfrpuy3t 139 21 are be VBP cord-252871-qfrpuy3t 139 22 conserved conserve VBN cord-252871-qfrpuy3t 139 23 across across IN cord-252871-qfrpuy3t 139 24 diverse diverse JJ cord-252871-qfrpuy3t 139 25 virus virus NN cord-252871-qfrpuy3t 139 26 families family NNS cord-252871-qfrpuy3t 139 27 ( ( -LRB- cord-252871-qfrpuy3t 139 28 e.g. e.g. RB cord-252871-qfrpuy3t 139 29 , , , cord-252871-qfrpuy3t 139 30 DNA dna NN cord-252871-qfrpuy3t 139 31 polymerase polymerase NN cord-252871-qfrpuy3t 139 32 is be VBZ cord-252871-qfrpuy3t 139 33 conserved conserve VBN cord-252871-qfrpuy3t 139 34 in in IN cord-252871-qfrpuy3t 139 35 many many JJ cord-252871-qfrpuy3t 139 36 DNA dna NN cord-252871-qfrpuy3t 139 37 viruses virus NNS cord-252871-qfrpuy3t 139 38 but but CC cord-252871-qfrpuy3t 139 39 not not RB cord-252871-qfrpuy3t 139 40 in in IN cord-252871-qfrpuy3t 139 41 papillomaviruses papillomaviruse NNS cord-252871-qfrpuy3t 139 42 , , , cord-252871-qfrpuy3t 139 43 and and CC cord-252871-qfrpuy3t 139 44 RNA RNA NNP cord-252871-qfrpuy3t 139 45 polymerase polymerase NN cord-252871-qfrpuy3t 139 46 is be VBZ cord-252871-qfrpuy3t 139 47 conserved conserve VBN cord-252871-qfrpuy3t 139 48 in in IN cord-252871-qfrpuy3t 139 49 many many JJ cord-252871-qfrpuy3t 139 50 RNA RNA NNP cord-252871-qfrpuy3t 139 51 viruses virus NNS cord-252871-qfrpuy3t 139 52 but but CC cord-252871-qfrpuy3t 139 53 not not RB cord-252871-qfrpuy3t 139 54 in in IN cord-252871-qfrpuy3t 139 55 satellite satellite NN cord-252871-qfrpuy3t 139 56 viruses virus NNS cord-252871-qfrpuy3t 139 57 ) ) -RRB- cord-252871-qfrpuy3t 139 58 . . . cord-252871-qfrpuy3t 140 1 The the DT cord-252871-qfrpuy3t 140 2 patchy patchy JJ cord-252871-qfrpuy3t 140 3 distribution distribution NN cord-252871-qfrpuy3t 140 4 of of IN cord-252871-qfrpuy3t 140 5 both both CC cord-252871-qfrpuy3t 140 6 the the DT cord-252871-qfrpuy3t 140 7 core core NN cord-252871-qfrpuy3t 140 8 and and CC cord-252871-qfrpuy3t 140 9 virus virus NN cord-252871-qfrpuy3t 140 10 - - HYPH cord-252871-qfrpuy3t 140 11 specific specific JJ cord-252871-qfrpuy3t 140 12 genes gene NNS cord-252871-qfrpuy3t 140 13 is be VBZ cord-252871-qfrpuy3t 140 14 expected expect VBN cord-252871-qfrpuy3t 140 15 from from IN cord-252871-qfrpuy3t 140 16 random random JJ cord-252871-qfrpuy3t 140 17 reductive reductive JJ cord-252871-qfrpuy3t 140 18 evolution evolution NN cord-252871-qfrpuy3t 140 19 where where WRB cord-252871-qfrpuy3t 140 20 lost lose VBN cord-252871-qfrpuy3t 140 21 and and CC cord-252871-qfrpuy3t 140 22 conserved conserve VBN cord-252871-qfrpuy3t 140 23 genes gene NNS cord-252871-qfrpuy3t 140 24 were be VBD cord-252871-qfrpuy3t 140 25 randomly randomly RB cord-252871-qfrpuy3t 140 26 selected select VBN cord-252871-qfrpuy3t 140 27 from from IN cord-252871-qfrpuy3t 140 28 ancient ancient JJ cord-252871-qfrpuy3t 140 29 cells cell NNS cord-252871-qfrpuy3t 140 30 . . . cord-252871-qfrpuy3t 141 1 We -PRON- PRP cord-252871-qfrpuy3t 141 2 therefore therefore RB cord-252871-qfrpuy3t 141 3 propose propose VBP cord-252871-qfrpuy3t 141 4 that that IN cord-252871-qfrpuy3t 141 5 viruses virus NNS cord-252871-qfrpuy3t 141 6 , , , cord-252871-qfrpuy3t 141 7 especially especially RB cord-252871-qfrpuy3t 141 8 DNA dna NN cord-252871-qfrpuy3t 141 9 viruses virus NNS cord-252871-qfrpuy3t 141 10 , , , cord-252871-qfrpuy3t 141 11 evolved evolve VBD cord-252871-qfrpuy3t 141 12 from from IN cord-252871-qfrpuy3t 141 13 one one CD cord-252871-qfrpuy3t 141 14 or or CC cord-252871-qfrpuy3t 141 15 multiple multiple JJ cord-252871-qfrpuy3t 141 16 ancient ancient JJ cord-252871-qfrpuy3t 141 17 cells cell NNS cord-252871-qfrpuy3t 141 18 via via IN cord-252871-qfrpuy3t 141 19 reduction reduction NN cord-252871-qfrpuy3t 141 20 [ [ -LRB- cord-252871-qfrpuy3t 141 21 11 11 CD cord-252871-qfrpuy3t 141 22 , , , cord-252871-qfrpuy3t 141 23 41 41 CD cord-252871-qfrpuy3t 141 24 , , , cord-252871-qfrpuy3t 141 25 51 51 CD cord-252871-qfrpuy3t 141 26 , , , cord-252871-qfrpuy3t 141 27 52 52 CD cord-252871-qfrpuy3t 141 28 ] ] -RRB- cord-252871-qfrpuy3t 141 29 . . . cord-252871-qfrpuy3t 142 1 This this DT cord-252871-qfrpuy3t 142 2 scenario scenario NN cord-252871-qfrpuy3t 142 3 better well RBR cord-252871-qfrpuy3t 142 4 aligns align VBZ cord-252871-qfrpuy3t 142 5 with with IN cord-252871-qfrpuy3t 142 6 the the DT cord-252871-qfrpuy3t 142 7 evolutionary evolutionary JJ cord-252871-qfrpuy3t 142 8 biology biology NN cord-252871-qfrpuy3t 142 9 of of IN cord-252871-qfrpuy3t 142 10 endosymbiotic endosymbiotic JJ cord-252871-qfrpuy3t 142 11 and and CC cord-252871-qfrpuy3t 142 12 parasitic parasitic JJ cord-252871-qfrpuy3t 142 13 cellular cellular JJ cord-252871-qfrpuy3t 142 14 organisms organism NNS cord-252871-qfrpuy3t 142 15 and and CC cord-252871-qfrpuy3t 142 16 is be VBZ cord-252871-qfrpuy3t 142 17 more more RBR cord-252871-qfrpuy3t 142 18 plausible plausible JJ cord-252871-qfrpuy3t 142 19 considering consider VBG cord-252871-qfrpuy3t 142 20 the the DT cord-252871-qfrpuy3t 142 21 unique unique JJ cord-252871-qfrpuy3t 142 22 composition composition NN cord-252871-qfrpuy3t 142 23 of of IN cord-252871-qfrpuy3t 142 24 virus virus NN cord-252871-qfrpuy3t 142 25 genomes genome NNS cord-252871-qfrpuy3t 142 26 . . . cord-252871-qfrpuy3t 143 1 The the DT cord-252871-qfrpuy3t 143 2 proposed propose VBN cord-252871-qfrpuy3t 143 3 reduction reduction NN cord-252871-qfrpuy3t 143 4 model model NN cord-252871-qfrpuy3t 143 5 is be VBZ cord-252871-qfrpuy3t 143 6 based base VBN cord-252871-qfrpuy3t 143 7 on on IN cord-252871-qfrpuy3t 143 8 the the DT cord-252871-qfrpuy3t 143 9 generic generic JJ cord-252871-qfrpuy3t 143 10 definition definition NN cord-252871-qfrpuy3t 143 11 of of IN cord-252871-qfrpuy3t 143 12 viruses virus NNS cord-252871-qfrpuy3t 143 13 and and CC cord-252871-qfrpuy3t 143 14 does do VBZ cord-252871-qfrpuy3t 143 15 not not RB cord-252871-qfrpuy3t 143 16 suggest suggest VB cord-252871-qfrpuy3t 143 17 that that IN cord-252871-qfrpuy3t 143 18 ancient ancient JJ cord-252871-qfrpuy3t 143 19 cells cell NNS cord-252871-qfrpuy3t 143 20 reduced reduce VBN cord-252871-qfrpuy3t 143 21 into into IN cord-252871-qfrpuy3t 143 22 virions virion NNS cord-252871-qfrpuy3t 143 23 . . . cord-252871-qfrpuy3t 144 1 That that DT cord-252871-qfrpuy3t 144 2 would would MD cord-252871-qfrpuy3t 144 3 be be VB cord-252871-qfrpuy3t 144 4 mistaking mistake VBG cord-252871-qfrpuy3t 144 5 viruses virus NNS cord-252871-qfrpuy3t 144 6 for for IN cord-252871-qfrpuy3t 144 7 their -PRON- PRP$ cord-252871-qfrpuy3t 144 8 virions virion NNS cord-252871-qfrpuy3t 144 9 , , , cord-252871-qfrpuy3t 144 10 a a DT cord-252871-qfrpuy3t 144 11 classical classical JJ cord-252871-qfrpuy3t 144 12 mistake mistake NN cord-252871-qfrpuy3t 144 13 that that WDT cord-252871-qfrpuy3t 144 14 we -PRON- PRP cord-252871-qfrpuy3t 144 15 have have VBP cord-252871-qfrpuy3t 144 16 just just RB cord-252871-qfrpuy3t 144 17 criticized criticize VBN cord-252871-qfrpuy3t 144 18 . . . cord-252871-qfrpuy3t 145 1 Instead instead RB cord-252871-qfrpuy3t 145 2 , , , cord-252871-qfrpuy3t 145 3 we -PRON- PRP cord-252871-qfrpuy3t 145 4 simply simply RB cord-252871-qfrpuy3t 145 5 propose propose VBP cord-252871-qfrpuy3t 145 6 that that IN cord-252871-qfrpuy3t 145 7 ancient ancient JJ cord-252871-qfrpuy3t 145 8 cells cell NNS cord-252871-qfrpuy3t 145 9 were be VBD cord-252871-qfrpuy3t 145 10 the the DT cord-252871-qfrpuy3t 145 11 first first JJ cord-252871-qfrpuy3t 145 12 to to TO cord-252871-qfrpuy3t 145 13 discover discover VB cord-252871-qfrpuy3t 145 14 the the DT cord-252871-qfrpuy3t 145 15 benefits benefit NNS cord-252871-qfrpuy3t 145 16 of of IN cord-252871-qfrpuy3t 145 17 parasitization parasitization NN cord-252871-qfrpuy3t 145 18 and and CC cord-252871-qfrpuy3t 145 19 propagation propagation NN cord-252871-qfrpuy3t 145 20 via via IN cord-252871-qfrpuy3t 145 21 released release VBN cord-252871-qfrpuy3t 145 22 particles particle NNS cord-252871-qfrpuy3t 145 23 ( ( -LRB- cord-252871-qfrpuy3t 145 24 e.g. e.g. RB cord-252871-qfrpuy3t 145 25 , , , cord-252871-qfrpuy3t 145 26 vesicles vesicle NNS cord-252871-qfrpuy3t 145 27 ) ) -RRB- cord-252871-qfrpuy3t 146 1 [ [ -LRB- cord-252871-qfrpuy3t 146 2 37 37 CD cord-252871-qfrpuy3t 146 3 ] ] -RRB- cord-252871-qfrpuy3t 146 4 . . . cord-252871-qfrpuy3t 147 1 Gradually gradually RB cord-252871-qfrpuy3t 147 2 , , , cord-252871-qfrpuy3t 147 3 the the DT cord-252871-qfrpuy3t 147 4 ancient ancient JJ cord-252871-qfrpuy3t 147 5 cells cell NNS cord-252871-qfrpuy3t 147 6 devolved devolve VBN cord-252871-qfrpuy3t 147 7 as as IN cord-252871-qfrpuy3t 147 8 the the DT cord-252871-qfrpuy3t 147 9 released release VBN cord-252871-qfrpuy3t 147 10 particles particle NNS cord-252871-qfrpuy3t 147 11 became become VBD cord-252871-qfrpuy3t 147 12 fully fully RB cord-252871-qfrpuy3t 147 13 capable capable JJ cord-252871-qfrpuy3t 147 14 of of IN cord-252871-qfrpuy3t 147 15 repeating repeat VBG cord-252871-qfrpuy3t 147 16 the the DT cord-252871-qfrpuy3t 147 17 cycle cycle NN cord-252871-qfrpuy3t 147 18 of of IN cord-252871-qfrpuy3t 147 19 invasion invasion NN cord-252871-qfrpuy3t 147 20 and and CC cord-252871-qfrpuy3t 147 21 escape escape VB cord-252871-qfrpuy3t 147 22 in in IN cord-252871-qfrpuy3t 147 23 coinhabiting coinhabite VBG cord-252871-qfrpuy3t 147 24 cellular cellular JJ cord-252871-qfrpuy3t 147 25 lineages lineage NNS cord-252871-qfrpuy3t 147 26 . . . cord-252871-qfrpuy3t 148 1 While while IN cord-252871-qfrpuy3t 148 2 the the DT cord-252871-qfrpuy3t 148 3 concept concept NN cord-252871-qfrpuy3t 148 4 of of IN cord-252871-qfrpuy3t 148 5 a a DT cord-252871-qfrpuy3t 148 6 ' ' `` cord-252871-qfrpuy3t 148 7 virus virus NN cord-252871-qfrpuy3t 148 8 - - HYPH cord-252871-qfrpuy3t 148 9 like like JJ cord-252871-qfrpuy3t 148 10 cell cell NN cord-252871-qfrpuy3t 148 11 ' ' '' cord-252871-qfrpuy3t 148 12 or or CC cord-252871-qfrpuy3t 148 13 a a DT cord-252871-qfrpuy3t 148 14 ' ' `` cord-252871-qfrpuy3t 148 15 cellular cellular JJ cord-252871-qfrpuy3t 148 16 ancestor ancestor NN cord-252871-qfrpuy3t 148 17 of of IN cord-252871-qfrpuy3t 148 18 virus virus NN cord-252871-qfrpuy3t 148 19 ' ' '' cord-252871-qfrpuy3t 148 20 may may MD cord-252871-qfrpuy3t 148 21 be be VB cord-252871-qfrpuy3t 148 22 difficult difficult JJ cord-252871-qfrpuy3t 148 23 to to TO cord-252871-qfrpuy3t 148 24 imagine imagine VB cord-252871-qfrpuy3t 148 25 , , , cord-252871-qfrpuy3t 148 26 we -PRON- PRP cord-252871-qfrpuy3t 148 27 already already RB cord-252871-qfrpuy3t 148 28 know know VBP cord-252871-qfrpuy3t 148 29 several several JJ cord-252871-qfrpuy3t 148 30 examples example NNS cord-252871-qfrpuy3t 148 31 of of IN cord-252871-qfrpuy3t 148 32 viral viral JJ cord-252871-qfrpuy3t 148 33 genome genome NN cord-252871-qfrpuy3t 148 34 endogenization endogenization NN cord-252871-qfrpuy3t 148 35 into into IN cord-252871-qfrpuy3t 148 36 host host NN cord-252871-qfrpuy3t 148 37 DNA DNA NNP cord-252871-qfrpuy3t 148 38 [ [ -LRB- cord-252871-qfrpuy3t 148 39 53 53 CD cord-252871-qfrpuy3t 148 40 ] ] -RRB- cord-252871-qfrpuy3t 148 41 and and CC cord-252871-qfrpuy3t 148 42 viral viral JJ cord-252871-qfrpuy3t 148 43 factories factory NNS cord-252871-qfrpuy3t 148 44 that that WDT cord-252871-qfrpuy3t 148 45 alter alter VBP cord-252871-qfrpuy3t 148 46 the the DT cord-252871-qfrpuy3t 148 47 nature nature NN cord-252871-qfrpuy3t 148 48 of of IN cord-252871-qfrpuy3t 148 49 the the DT cord-252871-qfrpuy3t 148 50 infected infected JJ cord-252871-qfrpuy3t 148 51 cells cell NNS cord-252871-qfrpuy3t 148 52 [ [ -LRB- cord-252871-qfrpuy3t 148 53 12 12 CD cord-252871-qfrpuy3t 148 54 , , , cord-252871-qfrpuy3t 148 55 18 18 CD cord-252871-qfrpuy3t 148 56 ] ] -RRB- cord-252871-qfrpuy3t 148 57 . . . cord-252871-qfrpuy3t 149 1 These these DT cord-252871-qfrpuy3t 149 2 modern modern JJ cord-252871-qfrpuy3t 149 3 - - HYPH cord-252871-qfrpuy3t 149 4 day day NN cord-252871-qfrpuy3t 149 5 events event NNS cord-252871-qfrpuy3t 149 6 transiently transiently RB cord-252871-qfrpuy3t 149 7 restore restore VBP cord-252871-qfrpuy3t 149 8 the the DT cord-252871-qfrpuy3t 149 9 ancient ancient JJ cord-252871-qfrpuy3t 149 10 ' ' `` cord-252871-qfrpuy3t 149 11 cellular cellular JJ cord-252871-qfrpuy3t 149 12 self self NN cord-252871-qfrpuy3t 149 13 ' ' '' cord-252871-qfrpuy3t 149 14 that that WDT cord-252871-qfrpuy3t 149 15 may may MD cord-252871-qfrpuy3t 149 16 have have VB cord-252871-qfrpuy3t 149 17 been be VBN cord-252871-qfrpuy3t 149 18 a a DT cord-252871-qfrpuy3t 149 19 more more RBR cord-252871-qfrpuy3t 149 20 permanent permanent JJ cord-252871-qfrpuy3t 149 21 feature feature NN cord-252871-qfrpuy3t 149 22 in in IN cord-252871-qfrpuy3t 149 23 the the DT cord-252871-qfrpuy3t 149 24 past past NN cord-252871-qfrpuy3t 149 25 . . . cord-252871-qfrpuy3t 150 1 In in IN cord-252871-qfrpuy3t 150 2 fact fact NN cord-252871-qfrpuy3t 150 3 , , , cord-252871-qfrpuy3t 150 4 cytoplasmic cytoplasmic JJ cord-252871-qfrpuy3t 150 5 virion virion NN cord-252871-qfrpuy3t 150 6 factories factory NNS cord-252871-qfrpuy3t 150 7 behave behave VBP cord-252871-qfrpuy3t 150 8 like like IN cord-252871-qfrpuy3t 150 9 a a DT cord-252871-qfrpuy3t 150 10 pseudonucleus pseudonucleus NN cord-252871-qfrpuy3t 150 11 where where WRB cord-252871-qfrpuy3t 150 12 virus virus NN cord-252871-qfrpuy3t 150 13 genome genome NN cord-252871-qfrpuy3t 150 14 replication replication NN cord-252871-qfrpuy3t 150 15 and and CC cord-252871-qfrpuy3t 150 16 translation translation NN cord-252871-qfrpuy3t 150 17 are be VBP cord-252871-qfrpuy3t 150 18 separated separate VBN cord-252871-qfrpuy3t 150 19 from from IN cord-252871-qfrpuy3t 150 20 host host NN cord-252871-qfrpuy3t 150 21 cytoplasm cytoplasm NN cord-252871-qfrpuy3t 150 22 [ [ -LRB- cord-252871-qfrpuy3t 150 23 54 54 CD cord-252871-qfrpuy3t 150 24 , , , cord-252871-qfrpuy3t 150 25 55 55 CD cord-252871-qfrpuy3t 150 26 ] ] -RRB- cord-252871-qfrpuy3t 150 27 . . . cord-252871-qfrpuy3t 151 1 Some some DT cord-252871-qfrpuy3t 151 2 authors author NNS cord-252871-qfrpuy3t 151 3 suggest suggest VBP cord-252871-qfrpuy3t 151 4 that that IN cord-252871-qfrpuy3t 151 5 the the DT cord-252871-qfrpuy3t 151 6 eukaryotic eukaryotic JJ cord-252871-qfrpuy3t 151 7 nucleus nucleus NN cord-252871-qfrpuy3t 151 8 likely likely RB cord-252871-qfrpuy3t 151 9 evolved evolve VBD cord-252871-qfrpuy3t 151 10 directly directly RB cord-252871-qfrpuy3t 151 11 from from IN cord-252871-qfrpuy3t 151 12 an an DT cord-252871-qfrpuy3t 151 13 ancient ancient JJ cord-252871-qfrpuy3t 151 14 viral viral JJ cord-252871-qfrpuy3t 151 15 factory factory NN cord-252871-qfrpuy3t 151 16 [ [ -LRB- cord-252871-qfrpuy3t 151 17 56 56 CD cord-252871-qfrpuy3t 151 18 , , , cord-252871-qfrpuy3t 151 19 57 57 CD cord-252871-qfrpuy3t 151 20 ] ] -RRB- cord-252871-qfrpuy3t 151 21 . . . cord-252871-qfrpuy3t 152 1 The the DT cord-252871-qfrpuy3t 152 2 ancient ancient JJ cord-252871-qfrpuy3t 152 3 pre pre AFX cord-252871-qfrpuy3t 152 4 - - NNP cord-252871-qfrpuy3t 152 5 LUCA LUCA NNP cord-252871-qfrpuy3t 152 6 cells cell NNS cord-252871-qfrpuy3t 152 7 likely likely RB cord-252871-qfrpuy3t 152 8 harbored harbor VBD cord-252871-qfrpuy3t 152 9 segmented segmented JJ cord-252871-qfrpuy3t 152 10 RNA RNA NNP cord-252871-qfrpuy3t 152 11 genomes genome NNS cord-252871-qfrpuy3t 152 12 [ [ -LRB- cord-252871-qfrpuy3t 152 13 41 41 CD cord-252871-qfrpuy3t 152 14 , , , cord-252871-qfrpuy3t 152 15 58 58 CD cord-252871-qfrpuy3t 152 16 , , , cord-252871-qfrpuy3t 152 17 59 59 CD cord-252871-qfrpuy3t 152 18 ] ] -RRB- cord-252871-qfrpuy3t 152 19 . . . cord-252871-qfrpuy3t 153 1 It -PRON- PRP cord-252871-qfrpuy3t 153 2 is be VBZ cord-252871-qfrpuy3t 153 3 therefore therefore RB cord-252871-qfrpuy3t 153 4 logical logical JJ cord-252871-qfrpuy3t 153 5 to to TO cord-252871-qfrpuy3t 153 6 think think VB cord-252871-qfrpuy3t 153 7 that that IN cord-252871-qfrpuy3t 153 8 RNA RNA NNP cord-252871-qfrpuy3t 153 9 viruses virus NNS cord-252871-qfrpuy3t 153 10 evolved evolve VBD cord-252871-qfrpuy3t 153 11 first first RB cord-252871-qfrpuy3t 153 12 from from IN cord-252871-qfrpuy3t 153 13 RNA RNA NNP cord-252871-qfrpuy3t 153 14 cells cell NNS cord-252871-qfrpuy3t 153 15 , , , cord-252871-qfrpuy3t 153 16 and and CC cord-252871-qfrpuy3t 153 17 that that IN cord-252871-qfrpuy3t 153 18 later later RB cord-252871-qfrpuy3t 153 19 , , , cord-252871-qfrpuy3t 153 20 DNA dna NN cord-252871-qfrpuy3t 153 21 viruses virus NNS cord-252871-qfrpuy3t 153 22 evolved evolve VBN cord-252871-qfrpuy3t 153 23 directly directly RB cord-252871-qfrpuy3t 153 24 from from IN cord-252871-qfrpuy3t 153 25 RNA RNA NNP cord-252871-qfrpuy3t 153 26 viruses virus NNS cord-252871-qfrpuy3t 153 27 , , , cord-252871-qfrpuy3t 153 28 and and CC cord-252871-qfrpuy3t 153 29 in in IN cord-252871-qfrpuy3t 153 30 parallel parallel JJ cord-252871-qfrpuy3t 153 31 , , , cord-252871-qfrpuy3t 153 32 DNA dna NN cord-252871-qfrpuy3t 153 33 cells cell NNS cord-252871-qfrpuy3t 153 34 evolved evolve VBN cord-252871-qfrpuy3t 153 35 from from IN cord-252871-qfrpuy3t 153 36 RNA RNA NNP cord-252871-qfrpuy3t 153 37 cells cell NNS cord-252871-qfrpuy3t 153 38 ( ( -LRB- cord-252871-qfrpuy3t 153 39 Figure figure NN cord-252871-qfrpuy3t 153 40 2A 2a CD cord-252871-qfrpuy3t 153 41 ) ) -RRB- cord-252871-qfrpuy3t 153 42 . . . cord-252871-qfrpuy3t 154 1 This this DT cord-252871-qfrpuy3t 154 2 scenario scenario NN cord-252871-qfrpuy3t 154 3 implies imply VBZ cord-252871-qfrpuy3t 154 4 that that IN cord-252871-qfrpuy3t 154 5 RNA RNA NNP cord-252871-qfrpuy3t 154 6 viruses virus NNS cord-252871-qfrpuy3t 154 7 are be VBP cord-252871-qfrpuy3t 154 8 the the DT cord-252871-qfrpuy3t 154 9 ancestors ancestor NNS cord-252871-qfrpuy3t 154 10 of of IN cord-252871-qfrpuy3t 154 11 DNA dna NN cord-252871-qfrpuy3t 154 12 viruses virus NNS cord-252871-qfrpuy3t 154 13 and and CC cord-252871-qfrpuy3t 154 14 was be VBD cord-252871-qfrpuy3t 154 15 supported support VBN cord-252871-qfrpuy3t 154 16 in in IN cord-252871-qfrpuy3t 154 17 a a DT cord-252871-qfrpuy3t 154 18 recent recent JJ cord-252871-qfrpuy3t 154 19 phylogenomic phylogenomic JJ cord-252871-qfrpuy3t 154 20 analysis analysis NN cord-252871-qfrpuy3t 154 21 [ [ -LRB- cord-252871-qfrpuy3t 154 22 41 41 CD cord-252871-qfrpuy3t 154 23 ] ] -RRB- cord-252871-qfrpuy3t 154 24 . . . cord-252871-qfrpuy3t 155 1 A a DT cord-252871-qfrpuy3t 155 2 second second JJ cord-252871-qfrpuy3t 155 3 alternative alternative NN cord-252871-qfrpuy3t 155 4 could could MD cord-252871-qfrpuy3t 155 5 be be VB cord-252871-qfrpuy3t 155 6 that that IN cord-252871-qfrpuy3t 155 7 RNA RNA NNP cord-252871-qfrpuy3t 155 8 viruses virus NNS cord-252871-qfrpuy3t 155 9 evolved evolve VBN cord-252871-qfrpuy3t 155 10 directly directly RB cord-252871-qfrpuy3t 155 11 from from IN cord-252871-qfrpuy3t 155 12 RNA RNA NNP cord-252871-qfrpuy3t 155 13 cells cell NNS cord-252871-qfrpuy3t 155 14 , , , cord-252871-qfrpuy3t 155 15 and and CC cord-252871-qfrpuy3t 155 16 DNA dna NN cord-252871-qfrpuy3t 155 17 viruses virus NNS cord-252871-qfrpuy3t 155 18 evolved evolve VBN cord-252871-qfrpuy3t 155 19 directly directly RB cord-252871-qfrpuy3t 155 20 from from IN cord-252871-qfrpuy3t 155 21 DNA dna NN cord-252871-qfrpuy3t 155 22 cells cell NNS cord-252871-qfrpuy3t 155 23 . . . cord-252871-qfrpuy3t 156 1 Thus thus RB cord-252871-qfrpuy3t 156 2 , , , cord-252871-qfrpuy3t 156 3 both both DT cord-252871-qfrpuy3t 156 4 groups group NNS cord-252871-qfrpuy3t 156 5 Trends Trends NNPS cord-252871-qfrpuy3t 156 6 in in IN cord-252871-qfrpuy3t 156 7 Microbiology Microbiology NNP cord-252871-qfrpuy3t 156 8 evolved evolve VBD cord-252871-qfrpuy3t 156 9 independently independently RB cord-252871-qfrpuy3t 156 10 from from IN cord-252871-qfrpuy3t 156 11 different different JJ cord-252871-qfrpuy3t 156 12 cellular cellular JJ cord-252871-qfrpuy3t 156 13 ancestors ancestor NNS cord-252871-qfrpuy3t 156 14 and and CC cord-252871-qfrpuy3t 156 15 possibly possibly RB cord-252871-qfrpuy3t 156 16 via via IN cord-252871-qfrpuy3t 156 17 different different JJ cord-252871-qfrpuy3t 156 18 mechanisms mechanism NNS cord-252871-qfrpuy3t 156 19 ( ( -LRB- cord-252871-qfrpuy3t 156 20 Figure figure NN cord-252871-qfrpuy3t 156 21 2B 2b CD cord-252871-qfrpuy3t 156 22 ) ) -RRB- cord-252871-qfrpuy3t 156 23 . . . cord-252871-qfrpuy3t 157 1 Finally finally RB cord-252871-qfrpuy3t 157 2 , , , cord-252871-qfrpuy3t 157 3 a a DT cord-252871-qfrpuy3t 157 4 third third JJ cord-252871-qfrpuy3t 157 5 alternative alternative NN cord-252871-qfrpuy3t 157 6 could could MD cord-252871-qfrpuy3t 157 7 be be VB cord-252871-qfrpuy3t 157 8 the the DT cord-252871-qfrpuy3t 157 9 evolution evolution NN cord-252871-qfrpuy3t 157 10 of of IN cord-252871-qfrpuy3t 157 11 RNA RNA NNP cord-252871-qfrpuy3t 157 12 viruses virus NNS cord-252871-qfrpuy3t 157 13 from from IN cord-252871-qfrpuy3t 157 14 RNA RNA NNP cord-252871-qfrpuy3t 157 15 cells cell NNS cord-252871-qfrpuy3t 157 16 . . . cord-252871-qfrpuy3t 158 1 RNA RNA NNP cord-252871-qfrpuy3t 158 2 viruses virus NNS cord-252871-qfrpuy3t 158 3 later later RB cord-252871-qfrpuy3t 158 4 invented invent VBD cord-252871-qfrpuy3t 158 5 DNA DNA NNP cord-252871-qfrpuy3t 158 6 to to TO cord-252871-qfrpuy3t 158 7 escape escape VB cord-252871-qfrpuy3t 158 8 the the DT cord-252871-qfrpuy3t 158 9 defenses defense NNS cord-252871-qfrpuy3t 158 10 of of IN cord-252871-qfrpuy3t 158 11 RNA RNA NNP cord-252871-qfrpuy3t 158 12 cells cell NNS cord-252871-qfrpuy3t 158 13 . . . cord-252871-qfrpuy3t 159 1 The the DT cord-252871-qfrpuy3t 159 2 invention invention NN cord-252871-qfrpuy3t 159 3 of of IN cord-252871-qfrpuy3t 159 4 DNA DNA NNP cord-252871-qfrpuy3t 159 5 was be VBD cord-252871-qfrpuy3t 159 6 later later RB cord-252871-qfrpuy3t 159 7 picked pick VBN cord-252871-qfrpuy3t 159 8 up up RP cord-252871-qfrpuy3t 159 9 by by IN cord-252871-qfrpuy3t 159 10 RNA RNA NNP cord-252871-qfrpuy3t 159 11 cells cell NNS cord-252871-qfrpuy3t 159 12 to to TO cord-252871-qfrpuy3t 159 13 become become VB cord-252871-qfrpuy3t 159 14 DNA dna NN cord-252871-qfrpuy3t 159 15 cells cell NNS cord-252871-qfrpuy3t 159 16 [ [ -LRB- cord-252871-qfrpuy3t 159 17 60 60 CD cord-252871-qfrpuy3t 159 18 , , , cord-252871-qfrpuy3t 159 19 61 61 CD cord-252871-qfrpuy3t 159 20 ] ] -RRB- cord-252871-qfrpuy3t 159 21 ( ( -LRB- cord-252871-qfrpuy3t 159 22 Figure figure NN cord-252871-qfrpuy3t 159 23 2C 2c NN cord-252871-qfrpuy3t 159 24 ) ) -RRB- cord-252871-qfrpuy3t 159 25 . . . cord-252871-qfrpuy3t 160 1 Testing test VBG cord-252871-qfrpuy3t 160 2 these these DT cord-252871-qfrpuy3t 160 3 alternatives alternative NNS cord-252871-qfrpuy3t 160 4 is be VBZ cord-252871-qfrpuy3t 160 5 challenging challenging JJ cord-252871-qfrpuy3t 160 6 since since IN cord-252871-qfrpuy3t 160 7 molecular molecular JJ cord-252871-qfrpuy3t 160 8 data datum NNS cord-252871-qfrpuy3t 160 9 are be VBP cord-252871-qfrpuy3t 160 10 limited limit VBN cord-252871-qfrpuy3t 160 11 in in IN cord-252871-qfrpuy3t 160 12 their -PRON- PRP$ cord-252871-qfrpuy3t 160 13 ability ability NN cord-252871-qfrpuy3t 160 14 to to TO cord-252871-qfrpuy3t 160 15 resolve resolve VB cord-252871-qfrpuy3t 160 16 deep deep JJ cord-252871-qfrpuy3t 160 17 evolutionary evolutionary JJ cord-252871-qfrpuy3t 160 18 events event NNS cord-252871-qfrpuy3t 160 19 . . . cord-252871-qfrpuy3t 161 1 In in IN cord-252871-qfrpuy3t 161 2 standard standard JJ cord-252871-qfrpuy3t 161 3 phylogenetic phylogenetic JJ cord-252871-qfrpuy3t 161 4 analyses analysis NNS cord-252871-qfrpuy3t 161 5 , , , cord-252871-qfrpuy3t 161 6 gene gene NN cord-252871-qfrpuy3t 161 7 and and CC cord-252871-qfrpuy3t 161 8 protein protein NN cord-252871-qfrpuy3t 161 9 sequences sequence NNS cord-252871-qfrpuy3t 161 10 are be VBP cord-252871-qfrpuy3t 161 11 aligned align VBN cord-252871-qfrpuy3t 161 12 to to TO cord-252871-qfrpuy3t 161 13 elucidate elucidate VB cord-252871-qfrpuy3t 161 14 the the DT cord-252871-qfrpuy3t 161 15 phylogenetic phylogenetic JJ cord-252871-qfrpuy3t 161 16 history history NN cord-252871-qfrpuy3t 161 17 of of IN cord-252871-qfrpuy3t 161 18 a a DT cord-252871-qfrpuy3t 161 19 group group NN cord-252871-qfrpuy3t 161 20 of of IN cord-252871-qfrpuy3t 161 21 organisms organism NNS cord-252871-qfrpuy3t 161 22 . . . cord-252871-qfrpuy3t 162 1 This this DT cord-252871-qfrpuy3t 162 2 alignment alignment NN cord-252871-qfrpuy3t 162 3 is be VBZ cord-252871-qfrpuy3t 162 4 used use VBN cord-252871-qfrpuy3t 162 5 to to TO cord-252871-qfrpuy3t 162 6 infer infer VB cord-252871-qfrpuy3t 162 7 a a DT cord-252871-qfrpuy3t 162 8 phylogenetic phylogenetic JJ cord-252871-qfrpuy3t 162 9 tree tree NN cord-252871-qfrpuy3t 162 10 using use VBG cord-252871-qfrpuy3t 162 11 various various JJ cord-252871-qfrpuy3t 162 12 methods method NNS cord-252871-qfrpuy3t 162 13 [ [ -LRB- cord-252871-qfrpuy3t 162 14 62 62 CD cord-252871-qfrpuy3t 162 15 ] ] -RRB- cord-252871-qfrpuy3t 162 16 . . . cord-252871-qfrpuy3t 163 1 While while IN cord-252871-qfrpuy3t 163 2 the the DT cord-252871-qfrpuy3t 163 3 alignment alignment NN cord-252871-qfrpuy3t 163 4 - - HYPH cord-252871-qfrpuy3t 163 5 dependent dependent JJ cord-252871-qfrpuy3t 163 6 methods method NNS cord-252871-qfrpuy3t 163 7 work work VBP cord-252871-qfrpuy3t 163 8 very very RB cord-252871-qfrpuy3t 163 9 well well RB cord-252871-qfrpuy3t 163 10 in in IN cord-252871-qfrpuy3t 163 11 resolving resolve VBG cord-252871-qfrpuy3t 163 12 the the DT cord-252871-qfrpuy3t 163 13 evolutionary evolutionary JJ cord-252871-qfrpuy3t 163 14 relationships relationship NNS cord-252871-qfrpuy3t 163 15 among among IN cord-252871-qfrpuy3t 163 16 closely closely RB cord-252871-qfrpuy3t 163 17 - - HYPH cord-252871-qfrpuy3t 163 18 related relate VBN cord-252871-qfrpuy3t 163 19 ( ( -LRB- cord-252871-qfrpuy3t 163 20 micro)organisms micro)organisms NNPS cord-252871-qfrpuy3t 163 21 and and CC cord-252871-qfrpuy3t 163 22 have have VBP cord-252871-qfrpuy3t 163 23 significant significant JJ cord-252871-qfrpuy3t 163 24 other other JJ cord-252871-qfrpuy3t 163 25 Trends trend NNS cord-252871-qfrpuy3t 163 26 in in IN cord-252871-qfrpuy3t 163 27 Microbiology Microbiology NNP cord-252871-qfrpuy3t 163 28 applications application NNS cord-252871-qfrpuy3t 163 29 , , , cord-252871-qfrpuy3t 163 30 they -PRON- PRP cord-252871-qfrpuy3t 163 31 are be VBP cord-252871-qfrpuy3t 163 32 probably probably RB cord-252871-qfrpuy3t 163 33 not not RB cord-252871-qfrpuy3t 163 34 suited suit VBN cord-252871-qfrpuy3t 163 35 for for IN cord-252871-qfrpuy3t 163 36 the the DT cord-252871-qfrpuy3t 163 37 origins origin NNS cord-252871-qfrpuy3t 163 38 or or CC cord-252871-qfrpuy3t 163 39 ' ' `` cord-252871-qfrpuy3t 163 40 tree tree NN cord-252871-qfrpuy3t 163 41 of of IN cord-252871-qfrpuy3t 163 42 life life NN cord-252871-qfrpuy3t 163 43 ' ' '' cord-252871-qfrpuy3t 163 44 research research NN cord-252871-qfrpuy3t 163 45 [ [ -LRB- cord-252871-qfrpuy3t 163 46 63 63 CD cord-252871-qfrpuy3t 163 47 ] ] -RRB- cord-252871-qfrpuy3t 163 48 . . . cord-252871-qfrpuy3t 164 1 This this DT cord-252871-qfrpuy3t 164 2 is be VBZ cord-252871-qfrpuy3t 164 3 especially especially RB cord-252871-qfrpuy3t 164 4 true true JJ cord-252871-qfrpuy3t 164 5 when when WRB cord-252871-qfrpuy3t 164 6 the the DT cord-252871-qfrpuy3t 164 7 objective objective NN cord-252871-qfrpuy3t 164 8 is be VBZ cord-252871-qfrpuy3t 164 9 to to TO cord-252871-qfrpuy3t 164 10 place place VB cord-252871-qfrpuy3t 164 11 fast fast RB cord-252871-qfrpuy3t 164 12 - - HYPH cord-252871-qfrpuy3t 164 13 evolving evolve VBG cord-252871-qfrpuy3t 164 14 organisms organism NNS cord-252871-qfrpuy3t 164 15 and and CC cord-252871-qfrpuy3t 164 16 viruses virus NNS cord-252871-qfrpuy3t 164 17 in in IN cord-252871-qfrpuy3t 164 18 the the DT cord-252871-qfrpuy3t 164 19 tree tree NN cord-252871-qfrpuy3t 164 20 of of IN cord-252871-qfrpuy3t 164 21 life life NN cord-252871-qfrpuy3t 164 22 [ [ -LRB- cord-252871-qfrpuy3t 164 23 64 64 CD cord-252871-qfrpuy3t 164 24 ] ] -RRB- cord-252871-qfrpuy3t 164 25 . . . cord-252871-qfrpuy3t 165 1 First first RB cord-252871-qfrpuy3t 165 2 , , , cord-252871-qfrpuy3t 165 3 the the DT cord-252871-qfrpuy3t 165 4 subset subset NN cord-252871-qfrpuy3t 165 5 of of IN cord-252871-qfrpuy3t 165 6 virus virus NN cord-252871-qfrpuy3t 165 7 genes gene NNS cord-252871-qfrpuy3t 165 8 for for IN cord-252871-qfrpuy3t 165 9 which which WDT cord-252871-qfrpuy3t 165 10 reliable reliable JJ cord-252871-qfrpuy3t 165 11 homologs homolog NNS cord-252871-qfrpuy3t 165 12 can can MD cord-252871-qfrpuy3t 165 13 be be VB cord-252871-qfrpuy3t 165 14 found find VBN cord-252871-qfrpuy3t 165 15 is be VBZ cord-252871-qfrpuy3t 165 16 extremely extremely RB cord-252871-qfrpuy3t 165 17 small small JJ cord-252871-qfrpuy3t 165 18 [ [ -LRB- cord-252871-qfrpuy3t 165 19 48 48 CD cord-252871-qfrpuy3t 165 20 ] ] -RRB- cord-252871-qfrpuy3t 165 21 . . . cord-252871-qfrpuy3t 166 1 This this DT cord-252871-qfrpuy3t 166 2 fact fact NN cord-252871-qfrpuy3t 166 3 greatly greatly RB cord-252871-qfrpuy3t 166 4 limits limit VBZ cord-252871-qfrpuy3t 166 5 the the DT cord-252871-qfrpuy3t 166 6 choice choice NN cord-252871-qfrpuy3t 166 7 and and CC cord-252871-qfrpuy3t 166 8 the the DT cord-252871-qfrpuy3t 166 9 number number NN cord-252871-qfrpuy3t 166 10 of of IN cord-252871-qfrpuy3t 166 11 available available JJ cord-252871-qfrpuy3t 166 12 orthologous orthologous JJ cord-252871-qfrpuy3t 166 13 genes gene NNS cord-252871-qfrpuy3t 166 14 to to TO cord-252871-qfrpuy3t 166 15 be be VB cord-252871-qfrpuy3t 166 16 used use VBN cord-252871-qfrpuy3t 166 17 in in IN cord-252871-qfrpuy3t 166 18 phylogeny phylogeny NN cord-252871-qfrpuy3t 166 19 reconstruction reconstruction NN cord-252871-qfrpuy3t 166 20 . . . cord-252871-qfrpuy3t 167 1 This this DT cord-252871-qfrpuy3t 167 2 sometimes sometimes RB cord-252871-qfrpuy3t 167 3 leads lead VBZ cord-252871-qfrpuy3t 167 4 authors author NNS cord-252871-qfrpuy3t 167 5 to to TO cord-252871-qfrpuy3t 167 6 resort resort VB cord-252871-qfrpuy3t 167 7 to to IN cord-252871-qfrpuy3t 167 8 subjective subjective JJ cord-252871-qfrpuy3t 167 9 , , , cord-252871-qfrpuy3t 167 10 nonstatistically nonstatistically RB cord-252871-qfrpuy3t 167 11 supported support VBN cord-252871-qfrpuy3t 167 12 approaches approach NNS cord-252871-qfrpuy3t 167 13 to to TO cord-252871-qfrpuy3t 167 14 suggest suggest VB cord-252871-qfrpuy3t 167 15 distant distant JJ cord-252871-qfrpuy3t 167 16 homology homology NN cord-252871-qfrpuy3t 167 17 relationships relationship NNS cord-252871-qfrpuy3t 167 18 [ [ -LRB- cord-252871-qfrpuy3t 167 19 65 65 CD cord-252871-qfrpuy3t 167 20 ] ] -RRB- cord-252871-qfrpuy3t 167 21 . . . cord-252871-qfrpuy3t 168 1 Another another DT cord-252871-qfrpuy3t 168 2 problem problem NN cord-252871-qfrpuy3t 168 3 is be VBZ cord-252871-qfrpuy3t 168 4 the the DT cord-252871-qfrpuy3t 168 5 recovery recovery NN cord-252871-qfrpuy3t 168 6 of of IN cord-252871-qfrpuy3t 168 7 a a DT cord-252871-qfrpuy3t 168 8 reliable reliable JJ cord-252871-qfrpuy3t 168 9 alignment alignment NN cord-252871-qfrpuy3t 168 10 of of IN cord-252871-qfrpuy3t 168 11 homologous homologous JJ cord-252871-qfrpuy3t 168 12 genes gene NNS cord-252871-qfrpuy3t 168 13 from from IN cord-252871-qfrpuy3t 168 14 a a DT cord-252871-qfrpuy3t 168 15 diverse diverse JJ cord-252871-qfrpuy3t 168 16 set set NN cord-252871-qfrpuy3t 168 17 of of IN cord-252871-qfrpuy3t 168 18 genomes genome NNS cord-252871-qfrpuy3t 168 19 . . . cord-252871-qfrpuy3t 169 1 In in IN cord-252871-qfrpuy3t 169 2 general general JJ cord-252871-qfrpuy3t 169 3 , , , cord-252871-qfrpuy3t 169 4 statistically statistically RB cord-252871-qfrpuy3t 169 5 detectable detectable JJ cord-252871-qfrpuy3t 169 6 sequence sequence NN cord-252871-qfrpuy3t 169 7 similarity similarity NN cord-252871-qfrpuy3t 169 8 fades fade VBZ cord-252871-qfrpuy3t 169 9 over over IN cord-252871-qfrpuy3t 169 10 evolutionary evolutionary JJ cord-252871-qfrpuy3t 169 11 time time NN cord-252871-qfrpuy3t 169 12 , , , cord-252871-qfrpuy3t 169 13 sometimes sometimes RB cord-252871-qfrpuy3t 169 14 leading lead VBG cord-252871-qfrpuy3t 169 15 to to TO cord-252871-qfrpuy3t 169 16 complete complete JJ cord-252871-qfrpuy3t 169 17 loss loss NN cord-252871-qfrpuy3t 169 18 of of IN cord-252871-qfrpuy3t 169 19 evolutionary evolutionary JJ cord-252871-qfrpuy3t 169 20 signal signal NN cord-252871-qfrpuy3t 169 21 due due IN cord-252871-qfrpuy3t 169 22 to to IN cord-252871-qfrpuy3t 169 23 mutation mutation NN cord-252871-qfrpuy3t 169 24 saturation saturation NN cord-252871-qfrpuy3t 169 25 [ [ -LRB- cord-252871-qfrpuy3t 169 26 66 66 CD cord-252871-qfrpuy3t 169 27 , , , cord-252871-qfrpuy3t 169 28 67 67 CD cord-252871-qfrpuy3t 169 29 ] ] -RRB- cord-252871-qfrpuy3t 169 30 . . . cord-252871-qfrpuy3t 170 1 In in IN cord-252871-qfrpuy3t 170 2 addition addition NN cord-252871-qfrpuy3t 170 3 , , , cord-252871-qfrpuy3t 170 4 protein protein NN cord-252871-qfrpuy3t 170 5 domain domain NN cord-252871-qfrpuy3t 170 6 ( ( -LRB- cord-252871-qfrpuy3t 170 7 i.e. i.e. FW cord-252871-qfrpuy3t 170 8 , , , cord-252871-qfrpuy3t 170 9 structural structural JJ cord-252871-qfrpuy3t 170 10 and and CC cord-252871-qfrpuy3t 170 11 functional functional JJ cord-252871-qfrpuy3t 170 12 units unit NNS cord-252871-qfrpuy3t 170 13 within within IN cord-252871-qfrpuy3t 170 14 proteins protein NNS cord-252871-qfrpuy3t 170 15 ) ) -RRB- cord-252871-qfrpuy3t 170 16 gains gain NNS cord-252871-qfrpuy3t 170 17 , , , cord-252871-qfrpuy3t 170 18 losses loss NNS cord-252871-qfrpuy3t 170 19 , , , cord-252871-qfrpuy3t 170 20 rearrangements rearrangement NNS cord-252871-qfrpuy3t 170 21 , , , cord-252871-qfrpuy3t 170 22 duplications duplication NNS cord-252871-qfrpuy3t 170 23 , , , cord-252871-qfrpuy3t 170 24 and and CC cord-252871-qfrpuy3t 170 25 transfers transfer NNS cord-252871-qfrpuy3t 170 26 are be VBP cord-252871-qfrpuy3t 170 27 frequent frequent JJ cord-252871-qfrpuy3t 170 28 events event NNS cord-252871-qfrpuy3t 170 29 in in IN cord-252871-qfrpuy3t 170 30 the the DT cord-252871-qfrpuy3t 170 31 evolution evolution NN cord-252871-qfrpuy3t 170 32 of of IN cord-252871-qfrpuy3t 170 33 genes gene NNS cord-252871-qfrpuy3t 170 34 and and CC cord-252871-qfrpuy3t 170 35 genomes genome NNS cord-252871-qfrpuy3t 170 36 [ [ -LRB- cord-252871-qfrpuy3t 170 37 68 68 CD cord-252871-qfrpuy3t 170 38 , , , cord-252871-qfrpuy3t 170 39 69 69 CD cord-252871-qfrpuy3t 170 40 ] ] -RRB- cord-252871-qfrpuy3t 170 41 . . . cord-252871-qfrpuy3t 171 1 These these DT cord-252871-qfrpuy3t 171 2 events event NNS cord-252871-qfrpuy3t 171 3 can can MD cord-252871-qfrpuy3t 171 4 happen happen VB cord-252871-qfrpuy3t 171 5 at at IN cord-252871-qfrpuy3t 171 6 different different JJ cord-252871-qfrpuy3t 171 7 rates rate NNS cord-252871-qfrpuy3t 171 8 in in IN cord-252871-qfrpuy3t 171 9 different different JJ cord-252871-qfrpuy3t 171 10 lineages lineage NNS cord-252871-qfrpuy3t 171 11 and and CC cord-252871-qfrpuy3t 171 12 thus thus RB cord-252871-qfrpuy3t 171 13 add add VB cord-252871-qfrpuy3t 171 14 many many JJ cord-252871-qfrpuy3t 171 15 unaligned unaligned JJ cord-252871-qfrpuy3t 171 16 or or CC cord-252871-qfrpuy3t 171 17 poorly poorly RB cord-252871-qfrpuy3t 171 18 aligned align VBN cord-252871-qfrpuy3t 171 19 regions region NNS cord-252871-qfrpuy3t 171 20 in in IN cord-252871-qfrpuy3t 171 21 sequence sequence NN cord-252871-qfrpuy3t 171 22 alignments alignment NNS cord-252871-qfrpuy3t 171 23 [ [ -LRB- cord-252871-qfrpuy3t 171 24 70 70 CD cord-252871-qfrpuy3t 171 25 ] ] -RRB- cord-252871-qfrpuy3t 171 26 . . . cord-252871-qfrpuy3t 172 1 Recovery recovery NN cord-252871-qfrpuy3t 172 2 of of IN cord-252871-qfrpuy3t 172 3 a a DT cord-252871-qfrpuy3t 172 4 reliable reliable JJ cord-252871-qfrpuy3t 172 5 alignment alignment NN cord-252871-qfrpuy3t 172 6 therefore therefore RB cord-252871-qfrpuy3t 172 7 often often RB cord-252871-qfrpuy3t 172 8 requires require VBZ cord-252871-qfrpuy3t 172 9 significant significant JJ cord-252871-qfrpuy3t 172 10 manual manual JJ cord-252871-qfrpuy3t 172 11 curation curation NN cord-252871-qfrpuy3t 172 12 ( ( -LRB- cord-252871-qfrpuy3t 172 13 e.g. e.g. RB cord-252871-qfrpuy3t 172 14 , , , cord-252871-qfrpuy3t 172 15 removal removal NN cord-252871-qfrpuy3t 172 16 of of IN cord-252871-qfrpuy3t 172 17 a a DT cord-252871-qfrpuy3t 172 18 large large JJ cord-252871-qfrpuy3t 172 19 proportion proportion NN cord-252871-qfrpuy3t 172 20 of of IN cord-252871-qfrpuy3t 172 21 poorly poorly RB cord-252871-qfrpuy3t 172 22 aligned align VBN cord-252871-qfrpuy3t 172 23 sites site NNS cord-252871-qfrpuy3t 172 24 ) ) -RRB- cord-252871-qfrpuy3t 172 25 , , , cord-252871-qfrpuy3t 172 26 which which WDT cord-252871-qfrpuy3t 172 27 impacts impact VBZ cord-252871-qfrpuy3t 172 28 reproducibility reproducibility NN cord-252871-qfrpuy3t 172 29 by by IN cord-252871-qfrpuy3t 172 30 introducing introduce VBG cord-252871-qfrpuy3t 172 31 subjectivity subjectivity NN cord-252871-qfrpuy3t 172 32 [ [ -LRB- cord-252871-qfrpuy3t 172 33 71 71 CD cord-252871-qfrpuy3t 172 34 ] ] -RRB- cord-252871-qfrpuy3t 172 35 , , , cord-252871-qfrpuy3t 172 36 and and CC cord-252871-qfrpuy3t 172 37 may may MD cord-252871-qfrpuy3t 172 38 even even RB cord-252871-qfrpuy3t 172 39 be be VB cord-252871-qfrpuy3t 172 40 impossible impossible JJ cord-252871-qfrpuy3t 172 41 for for IN cord-252871-qfrpuy3t 172 42 diverse diverse JJ cord-252871-qfrpuy3t 172 43 RNA RNA NNP cord-252871-qfrpuy3t 172 44 virus virus NN cord-252871-qfrpuy3t 172 45 groups group NNS cord-252871-qfrpuy3t 172 46 [ [ -LRB- cord-252871-qfrpuy3t 172 47 64 64 CD cord-252871-qfrpuy3t 172 48 ] ] -RRB- cord-252871-qfrpuy3t 172 49 . . . cord-252871-qfrpuy3t 173 1 Indeed indeed RB cord-252871-qfrpuy3t 173 2 , , , cord-252871-qfrpuy3t 173 3 the the DT cord-252871-qfrpuy3t 173 4 genomes genome NNS cord-252871-qfrpuy3t 173 5 of of IN cord-252871-qfrpuy3t 173 6 RNA RNA NNP cord-252871-qfrpuy3t 173 7 and and CC cord-252871-qfrpuy3t 173 8 retrotranscribing retrotranscribing NN cord-252871-qfrpuy3t 173 9 viruses virus NNS cord-252871-qfrpuy3t 173 10 exhibit exhibit VBP cord-252871-qfrpuy3t 173 11 very very RB cord-252871-qfrpuy3t 173 12 high high JJ cord-252871-qfrpuy3t 173 13 mutation mutation NN cord-252871-qfrpuy3t 173 14 rates rate NNS cord-252871-qfrpuy3t 173 15 [ [ -LRB- cord-252871-qfrpuy3t 173 16 72 72 CD cord-252871-qfrpuy3t 173 17 ] ] -RRB- cord-252871-qfrpuy3t 173 18 . . . cord-252871-qfrpuy3t 174 1 HIV HIV NNP cord-252871-qfrpuy3t 174 2 lineages lineage NNS cord-252871-qfrpuy3t 174 3 evolving evolve VBG cord-252871-qfrpuy3t 174 4 within within IN cord-252871-qfrpuy3t 174 5 the the DT cord-252871-qfrpuy3t 174 6 same same JJ cord-252871-qfrpuy3t 174 7 host host NN cord-252871-qfrpuy3t 174 8 can can MD cord-252871-qfrpuy3t 174 9 differ differ VB cord-252871-qfrpuy3t 174 10 by by IN cord-252871-qfrpuy3t 174 11 5 5 CD cord-252871-qfrpuy3t 174 12 - - SYM cord-252871-qfrpuy3t 174 13 10 10 CD cord-252871-qfrpuy3t 174 14 % % NN cord-252871-qfrpuy3t 174 15 whereas whereas IN cord-252871-qfrpuy3t 174 16 intrahuman intrahuman JJ cord-252871-qfrpuy3t 174 17 genetic genetic JJ cord-252871-qfrpuy3t 174 18 variation variation NN cord-252871-qfrpuy3t 174 19 could could MD cord-252871-qfrpuy3t 174 20 be be VB cord-252871-qfrpuy3t 174 21 < < $ cord-252871-qfrpuy3t 174 22 0.1 0.1 CD cord-252871-qfrpuy3t 174 23 % % NN cord-252871-qfrpuy3t 174 24 even even RB cord-252871-qfrpuy3t 174 25 after after IN cord-252871-qfrpuy3t 174 26 2.5 2.5 CD cord-252871-qfrpuy3t 174 27 million million CD cord-252871-qfrpuy3t 174 28 years year NNS cord-252871-qfrpuy3t 174 29 [ [ -LRB- cord-252871-qfrpuy3t 174 30 73 73 CD cord-252871-qfrpuy3t 174 31 ] ] -RRB- cord-252871-qfrpuy3t 174 32 . . . cord-252871-qfrpuy3t 175 1 These these DT cord-252871-qfrpuy3t 175 2 facts fact NNS cord-252871-qfrpuy3t 175 3 greatly greatly RB cord-252871-qfrpuy3t 175 4 limit limit VBP cord-252871-qfrpuy3t 175 5 our -PRON- PRP$ cord-252871-qfrpuy3t 175 6 ability ability NN cord-252871-qfrpuy3t 175 7 to to TO cord-252871-qfrpuy3t 175 8 reconstruct reconstruct VB cord-252871-qfrpuy3t 175 9 past past JJ cord-252871-qfrpuy3t 175 10 evolutionary evolutionary JJ cord-252871-qfrpuy3t 175 11 events event NNS cord-252871-qfrpuy3t 175 12 using use VBG cord-252871-qfrpuy3t 175 13 molecular molecular JJ cord-252871-qfrpuy3t 175 14 sequence sequence NN cord-252871-qfrpuy3t 175 15 information information NN cord-252871-qfrpuy3t 175 16 alone alone RB cord-252871-qfrpuy3t 175 17 and and CC cord-252871-qfrpuy3t 175 18 prompt prompt VB cord-252871-qfrpuy3t 175 19 us -PRON- PRP cord-252871-qfrpuy3t 175 20 to to TO cord-252871-qfrpuy3t 175 21 evaluate evaluate VB cord-252871-qfrpuy3t 175 22 the the DT cord-252871-qfrpuy3t 175 23 potential potential NN cord-252871-qfrpuy3t 175 24 of of IN cord-252871-qfrpuy3t 175 25 alternative alternative NN cord-252871-qfrpuy3t 175 26 , , , cord-252871-qfrpuy3t 175 27 more more RBR cord-252871-qfrpuy3t 175 28 conserved conserved JJ cord-252871-qfrpuy3t 175 29 , , , cord-252871-qfrpuy3t 175 30 molecular molecular JJ cord-252871-qfrpuy3t 175 31 characters character NNS cord-252871-qfrpuy3t 175 32 such such JJ cord-252871-qfrpuy3t 175 33 as as IN cord-252871-qfrpuy3t 175 34 protein protein NN cord-252871-qfrpuy3t 175 35 structures structure NNS cord-252871-qfrpuy3t 175 36 [ [ -LRB- cord-252871-qfrpuy3t 175 37 74 74 CD cord-252871-qfrpuy3t 175 38 ] ] -RRB- cord-252871-qfrpuy3t 175 39 ( ( -LRB- cord-252871-qfrpuy3t 175 40 Box Box NNP cord-252871-qfrpuy3t 175 41 1 1 CD cord-252871-qfrpuy3t 175 42 ) ) -RRB- cord-252871-qfrpuy3t 175 43 . . . cord-252871-qfrpuy3t 176 1 Viruses virus NNS cord-252871-qfrpuy3t 176 2 can can MD cord-252871-qfrpuy3t 176 3 be be VB cord-252871-qfrpuy3t 176 4 better well RBR cord-252871-qfrpuy3t 176 5 defined define VBN cord-252871-qfrpuy3t 176 6 based base VBN cord-252871-qfrpuy3t 176 7 on on IN cord-252871-qfrpuy3t 176 8 the the DT cord-252871-qfrpuy3t 176 9 generic generic JJ cord-252871-qfrpuy3t 176 10 features feature NNS cord-252871-qfrpuy3t 176 11 of of IN cord-252871-qfrpuy3t 176 12 genome genome NN cord-252871-qfrpuy3t 176 13 dissemination dissemination NN cord-252871-qfrpuy3t 176 14 rather rather RB cord-252871-qfrpuy3t 176 15 than than IN cord-252871-qfrpuy3t 176 16 specific specific JJ cord-252871-qfrpuy3t 176 17 virion virion NN cord-252871-qfrpuy3t 176 18 - - HYPH cord-252871-qfrpuy3t 176 19 associated associate VBN cord-252871-qfrpuy3t 176 20 or or CC cord-252871-qfrpuy3t 176 21 physical physical JJ cord-252871-qfrpuy3t 176 22 ( ( -LRB- cord-252871-qfrpuy3t 176 23 size size NN cord-252871-qfrpuy3t 176 24 ) ) -RRB- cord-252871-qfrpuy3t 176 25 properties property NNS cord-252871-qfrpuy3t 176 26 . . . cord-252871-qfrpuy3t 177 1 The the DT cord-252871-qfrpuy3t 177 2 defining define VBG cord-252871-qfrpuy3t 177 3 feature feature NN cord-252871-qfrpuy3t 177 4 of of IN cord-252871-qfrpuy3t 177 5 virus virus NN cord-252871-qfrpuy3t 177 6 genomes genome NNS cord-252871-qfrpuy3t 177 7 is be VBZ cord-252871-qfrpuy3t 177 8 the the DT cord-252871-qfrpuy3t 177 9 existence existence NN cord-252871-qfrpuy3t 177 10 and and CC cord-252871-qfrpuy3t 177 11 abundance abundance NN cord-252871-qfrpuy3t 177 12 of of IN cord-252871-qfrpuy3t 177 13 virus virus NN cord-252871-qfrpuy3t 177 14 - - HYPH cord-252871-qfrpuy3t 177 15 specific specific JJ cord-252871-qfrpuy3t 177 16 genes gene NNS cord-252871-qfrpuy3t 177 17 and and CC cord-252871-qfrpuy3t 177 18 protein protein NN cord-252871-qfrpuy3t 177 19 folds fold NNS cord-252871-qfrpuy3t 177 20 that that WDT cord-252871-qfrpuy3t 177 21 have have VBP cord-252871-qfrpuy3t 177 22 no no DT cord-252871-qfrpuy3t 177 23 homologs homolog NNS cord-252871-qfrpuy3t 177 24 in in IN cord-252871-qfrpuy3t 177 25 the the DT cord-252871-qfrpuy3t 177 26 cellular cellular JJ cord-252871-qfrpuy3t 177 27 world world NN cord-252871-qfrpuy3t 177 28 . . . cord-252871-qfrpuy3t 178 1 These these DT cord-252871-qfrpuy3t 178 2 genes gene NNS cord-252871-qfrpuy3t 178 3 are be VBP cord-252871-qfrpuy3t 178 4 rarely rarely RB cord-252871-qfrpuy3t 178 5 discussed discuss VBN cord-252871-qfrpuy3t 178 6 in in IN cord-252871-qfrpuy3t 178 7 the the DT cord-252871-qfrpuy3t 178 8 models model NNS cord-252871-qfrpuy3t 178 9 of of IN cord-252871-qfrpuy3t 178 10 virus virus NN cord-252871-qfrpuy3t 178 11 origin origin NN cord-252871-qfrpuy3t 178 12 and and CC cord-252871-qfrpuy3t 178 13 evolution evolution NN cord-252871-qfrpuy3t 178 14 , , , cord-252871-qfrpuy3t 178 15 and and CC cord-252871-qfrpuy3t 178 16 instead instead RB cord-252871-qfrpuy3t 178 17 most most JJS cord-252871-qfrpuy3t 178 18 evolutionary evolutionary JJ cord-252871-qfrpuy3t 178 19 studies study NNS cord-252871-qfrpuy3t 178 20 rely rely VBP cord-252871-qfrpuy3t 178 21 on on IN cord-252871-qfrpuy3t 178 22 a a DT cord-252871-qfrpuy3t 178 23 very very RB cord-252871-qfrpuy3t 178 24 small small JJ cord-252871-qfrpuy3t 178 25 subset subset NN cord-252871-qfrpuy3t 178 26 of of IN cord-252871-qfrpuy3t 178 27 viral viral JJ cord-252871-qfrpuy3t 178 28 genes gene NNS cord-252871-qfrpuy3t 178 29 for for IN cord-252871-qfrpuy3t 178 30 which which WDT cord-252871-qfrpuy3t 178 31 we -PRON- PRP cord-252871-qfrpuy3t 178 32 can can MD cord-252871-qfrpuy3t 178 33 find find VB cord-252871-qfrpuy3t 178 34 reliable reliable JJ cord-252871-qfrpuy3t 178 35 cellular cellular JJ cord-252871-qfrpuy3t 178 36 homologs homolog NNS cord-252871-qfrpuy3t 178 37 . . . cord-252871-qfrpuy3t 179 1 Often often RB cord-252871-qfrpuy3t 179 2 such such JJ cord-252871-qfrpuy3t 179 3 homologies homology NNS cord-252871-qfrpuy3t 179 4 are be VBP cord-252871-qfrpuy3t 179 5 interpreted interpret VBN cord-252871-qfrpuy3t 179 6 as as IN cord-252871-qfrpuy3t 179 7 gene gene NN cord-252871-qfrpuy3t 179 8 uptake uptake NN cord-252871-qfrpuy3t 179 9 from from IN cord-252871-qfrpuy3t 179 10 cells cell NNS cord-252871-qfrpuy3t 179 11 by by IN cord-252871-qfrpuy3t 179 12 viruses virus NNS cord-252871-qfrpuy3t 179 13 , , , cord-252871-qfrpuy3t 179 14 which which WDT cord-252871-qfrpuy3t 179 15 is be VBZ cord-252871-qfrpuy3t 179 16 an an DT cord-252871-qfrpuy3t 179 17 oversimplified oversimplified JJ cord-252871-qfrpuy3t 179 18 notion notion NN cord-252871-qfrpuy3t 179 19 for for IN cord-252871-qfrpuy3t 179 20 the the DT cord-252871-qfrpuy3t 179 21 evolution evolution NN cord-252871-qfrpuy3t 179 22 of of IN cord-252871-qfrpuy3t 179 23 virus virus NN cord-252871-qfrpuy3t 179 24 genomes genome NNS cord-252871-qfrpuy3t 179 25 . . . cord-252871-qfrpuy3t 180 1 Moreover moreover RB cord-252871-qfrpuy3t 180 2 , , , cord-252871-qfrpuy3t 180 3 the the DT cord-252871-qfrpuy3t 180 4 fast fast JJ cord-252871-qfrpuy3t 180 5 mutation mutation NN cord-252871-qfrpuy3t 180 6 rates rate NNS cord-252871-qfrpuy3t 180 7 of of IN cord-252871-qfrpuy3t 180 8 RNA RNA NNP cord-252871-qfrpuy3t 180 9 and and CC cord-252871-qfrpuy3t 180 10 retrotranscribing retrotranscribing NN cord-252871-qfrpuy3t 180 11 viruses virus NNS cord-252871-qfrpuy3t 180 12 almost almost RB cord-252871-qfrpuy3t 180 13 make make VBP cord-252871-qfrpuy3t 180 14 it -PRON- PRP cord-252871-qfrpuy3t 180 15 impossible impossible JJ cord-252871-qfrpuy3t 180 16 to to TO cord-252871-qfrpuy3t 180 17 recover recover VB cord-252871-qfrpuy3t 180 18 a a DT cord-252871-qfrpuy3t 180 19 reliable reliable JJ cord-252871-qfrpuy3t 180 20 alignment alignment NN cord-252871-qfrpuy3t 180 21 for for IN cord-252871-qfrpuy3t 180 22 deep deep JJ cord-252871-qfrpuy3t 180 23 virus virus NN cord-252871-qfrpuy3t 180 24 evolutionary evolutionary JJ cord-252871-qfrpuy3t 180 25 studies study NNS cord-252871-qfrpuy3t 180 26 . . . cord-252871-qfrpuy3t 181 1 In in IN cord-252871-qfrpuy3t 181 2 this this DT cord-252871-qfrpuy3t 181 3 regard regard NN cord-252871-qfrpuy3t 181 4 , , , cord-252871-qfrpuy3t 181 5 focusing focus VBG cord-252871-qfrpuy3t 181 6 on on IN cord-252871-qfrpuy3t 181 7 alternative alternative JJ cord-252871-qfrpuy3t 181 8 molecular molecular JJ cord-252871-qfrpuy3t 181 9 characters character NNS cord-252871-qfrpuy3t 181 10 that that WDT cord-252871-qfrpuy3t 181 11 are be VBP cord-252871-qfrpuy3t 181 12 better well RBR cord-252871-qfrpuy3t 181 13 conserved conserve VBN cord-252871-qfrpuy3t 181 14 in in IN cord-252871-qfrpuy3t 181 15 evolution evolution NN cord-252871-qfrpuy3t 181 16 ( ( -LRB- cord-252871-qfrpuy3t 181 17 e.g. e.g. RB cord-252871-qfrpuy3t 181 18 , , , cord-252871-qfrpuy3t 181 19 protein protein NN cord-252871-qfrpuy3t 181 20 structures structure NNS cord-252871-qfrpuy3t 181 21 ) ) -RRB- cord-252871-qfrpuy3t 181 22 can can MD cord-252871-qfrpuy3t 181 23 possibly possibly RB cord-252871-qfrpuy3t 181 24 provide provide VB cord-252871-qfrpuy3t 181 25 better well JJR cord-252871-qfrpuy3t 181 26 solutions solution NNS cord-252871-qfrpuy3t 181 27 . . . cord-252871-qfrpuy3t 182 1 Viruses virus NNS cord-252871-qfrpuy3t 182 2 are be VBP cord-252871-qfrpuy3t 182 3 likely likely RB cord-252871-qfrpuy3t 182 4 very very RB cord-252871-qfrpuy3t 182 5 old old JJ cord-252871-qfrpuy3t 182 6 and and CC cord-252871-qfrpuy3t 182 7 originated originate VBD cord-252871-qfrpuy3t 182 8 from from IN cord-252871-qfrpuy3t 182 9 ancient ancient JJ cord-252871-qfrpuy3t 182 10 RNA RNA NNP cord-252871-qfrpuy3t 182 11 cells cell NNS cord-252871-qfrpuy3t 182 12 that that WDT cord-252871-qfrpuy3t 182 13 predated predate VBD cord-252871-qfrpuy3t 182 14 LUCA LUCA NNP cord-252871-qfrpuy3t 182 15 . . . cord-252871-qfrpuy3t 183 1 They -PRON- PRP cord-252871-qfrpuy3t 183 2 continue continue VBP cord-252871-qfrpuy3t 183 3 to to TO cord-252871-qfrpuy3t 183 4 play play VB cord-252871-qfrpuy3t 183 5 important important JJ cord-252871-qfrpuy3t 183 6 roles role NNS cord-252871-qfrpuy3t 183 7 in in IN cord-252871-qfrpuy3t 183 8 the the DT cord-252871-qfrpuy3t 183 9 evolution evolution NN cord-252871-qfrpuy3t 183 10 of of IN cord-252871-qfrpuy3t 183 11 cells cell NNS cord-252871-qfrpuy3t 183 12 and and CC cord-252871-qfrpuy3t 183 13 exert exert VB cord-252871-qfrpuy3t 183 14 enormous enormous JJ cord-252871-qfrpuy3t 183 15 pressure pressure NN cord-252871-qfrpuy3t 183 16 on on IN cord-252871-qfrpuy3t 183 17 human human JJ cord-252871-qfrpuy3t 183 18 health health NN cord-252871-qfrpuy3t 183 19 and and CC cord-252871-qfrpuy3t 183 20 the the DT cord-252871-qfrpuy3t 183 21 global global JJ cord-252871-qfrpuy3t 183 22 economy economy NN cord-252871-qfrpuy3t 183 23 . . . cord-252871-qfrpuy3t 184 1 Updating update VBG cord-252871-qfrpuy3t 184 2 our -PRON- PRP$ cord-252871-qfrpuy3t 184 3 views view NNS cord-252871-qfrpuy3t 184 4 on on IN cord-252871-qfrpuy3t 184 5 the the DT cord-252871-qfrpuy3t 184 6 origins origin NNS cord-252871-qfrpuy3t 184 7 and and CC cord-252871-qfrpuy3t 184 8 definitions definition NNS cord-252871-qfrpuy3t 184 9 of of IN cord-252871-qfrpuy3t 184 10 viruses virus NNS cord-252871-qfrpuy3t 184 11 ( ( -LRB- cord-252871-qfrpuy3t 184 12 e.g. e.g. RB cord-252871-qfrpuy3t 184 13 , , , cord-252871-qfrpuy3t 184 14 the the DT cord-252871-qfrpuy3t 184 15 distinction distinction NN cord-252871-qfrpuy3t 184 16 between between IN cord-252871-qfrpuy3t 184 17 virion virion NN cord-252871-qfrpuy3t 184 18 and and CC cord-252871-qfrpuy3t 184 19 virus virus NN cord-252871-qfrpuy3t 184 20 ) ) -RRB- cord-252871-qfrpuy3t 184 21 may may MD cord-252871-qfrpuy3t 184 22 also also RB cord-252871-qfrpuy3t 184 23 help help VB cord-252871-qfrpuy3t 184 24 to to TO cord-252871-qfrpuy3t 184 25 clarify clarify VB cord-252871-qfrpuy3t 184 26 our -PRON- PRP$ cord-252871-qfrpuy3t 184 27 thinking thinking NN cord-252871-qfrpuy3t 184 28 about about IN cord-252871-qfrpuy3t 184 29 the the DT cord-252871-qfrpuy3t 184 30 risk risk NN cord-252871-qfrpuy3t 184 31 of of IN cord-252871-qfrpuy3t 184 32 emergence emergence NN cord-252871-qfrpuy3t 184 33 and and CC cord-252871-qfrpuy3t 184 34 spread spread NN cord-252871-qfrpuy3t 184 35 of of IN cord-252871-qfrpuy3t 184 36 new new JJ cord-252871-qfrpuy3t 184 37 viral viral JJ cord-252871-qfrpuy3t 184 38 diseases disease NNS cord-252871-qfrpuy3t 184 39 ( ( -LRB- cord-252871-qfrpuy3t 184 40 see see VB cord-252871-qfrpuy3t 184 41 Outstanding Outstanding NNP cord-252871-qfrpuy3t 184 42 Questions Questions NNPS cord-252871-qfrpuy3t 184 43 ) ) -RRB- cord-252871-qfrpuy3t 184 44 . . . cord-252871-qfrpuy3t 185 1 How how WRB cord-252871-qfrpuy3t 185 2 to to TO cord-252871-qfrpuy3t 185 3 visualize visualize VB cord-252871-qfrpuy3t 185 4 and and CC cord-252871-qfrpuy3t 185 5 illustrate illustrate VB cord-252871-qfrpuy3t 185 6 viruses virus NNS cord-252871-qfrpuy3t 185 7 ( ( -LRB- cord-252871-qfrpuy3t 185 8 virus virus NN cord-252871-qfrpuy3t 185 9 factories factory NNS cord-252871-qfrpuy3t 185 10 ) ) -RRB- cord-252871-qfrpuy3t 185 11 if if IN cord-252871-qfrpuy3t 185 12 virions virion NNS cord-252871-qfrpuy3t 185 13 can can MD cord-252871-qfrpuy3t 185 14 not not RB cord-252871-qfrpuy3t 185 15 and and CC cord-252871-qfrpuy3t 185 16 should should MD cord-252871-qfrpuy3t 185 17 not not RB cord-252871-qfrpuy3t 185 18 be be VB cord-252871-qfrpuy3t 185 19 used use VBN cord-252871-qfrpuy3t 185 20 to to TO cord-252871-qfrpuy3t 185 21 describe describe VB cord-252871-qfrpuy3t 185 22 viruses virus NNS cord-252871-qfrpuy3t 185 23 ? ? . cord-252871-qfrpuy3t 186 1 How how WRB cord-252871-qfrpuy3t 186 2 are be VBP cord-252871-qfrpuy3t 186 3 RNA RNA NNP cord-252871-qfrpuy3t 186 4 and and CC cord-252871-qfrpuy3t 186 5 DNA dna NN cord-252871-qfrpuy3t 186 6 viruses virus NNS cord-252871-qfrpuy3t 186 7 evolutionarily evolutionarily RB cord-252871-qfrpuy3t 186 8 related relate VBN cord-252871-qfrpuy3t 186 9 ? ? . cord-252871-qfrpuy3t 187 1 Do do VBP cord-252871-qfrpuy3t 187 2 well well RB cord-252871-qfrpuy3t 187 3 defined define VBN cord-252871-qfrpuy3t 187 4 boundaries boundary NNS cord-252871-qfrpuy3t 187 5 exist exist VBP cord-252871-qfrpuy3t 187 6 between between IN cord-252871-qfrpuy3t 187 7 cellular cellular JJ cord-252871-qfrpuy3t 187 8 and and CC cord-252871-qfrpuy3t 187 9 viral viral JJ cord-252871-qfrpuy3t 187 10 lineages lineage NNS cord-252871-qfrpuy3t 187 11 ? ? . cord-252871-qfrpuy3t 188 1 How how WRB cord-252871-qfrpuy3t 188 2 do do VBP cord-252871-qfrpuy3t 188 3 we -PRON- PRP cord-252871-qfrpuy3t 188 4 explain explain VB cord-252871-qfrpuy3t 188 5 the the DT cord-252871-qfrpuy3t 188 6 origin origin NN cord-252871-qfrpuy3t 188 7 and and CC cord-252871-qfrpuy3t 188 8 abundance abundance NN cord-252871-qfrpuy3t 188 9 of of IN cord-252871-qfrpuy3t 188 10 virus virus NN cord-252871-qfrpuy3t 188 11 - - HYPH cord-252871-qfrpuy3t 188 12 specific specific JJ cord-252871-qfrpuy3t 188 13 genes gene NNS cord-252871-qfrpuy3t 188 14 in in IN cord-252871-qfrpuy3t 188 15 viral viral JJ cord-252871-qfrpuy3t 188 16 genomes genome NNS cord-252871-qfrpuy3t 188 17 ? ? . cord-252871-qfrpuy3t 189 1 Can Can MD cord-252871-qfrpuy3t 189 2 protein protein NN cord-252871-qfrpuy3t 189 3 structure structure NN cord-252871-qfrpuy3t 189 4 - - HYPH cord-252871-qfrpuy3t 189 5 based base VBN cord-252871-qfrpuy3t 189 6 methods method NNS cord-252871-qfrpuy3t 189 7 improve improve VBP cord-252871-qfrpuy3t 189 8 the the DT cord-252871-qfrpuy3t 189 9 evolutionary evolutionary JJ cord-252871-qfrpuy3t 189 10 studies study NNS cord-252871-qfrpuy3t 189 11 of of IN cord-252871-qfrpuy3t 189 12 viruses virus NNS cord-252871-qfrpuy3t 189 13 ? ? . cord-252871-qfrpuy3t 190 1 Advancements advancement NNS cord-252871-qfrpuy3t 190 2 in in IN cord-252871-qfrpuy3t 190 3 structural structural JJ cord-252871-qfrpuy3t 190 4 biology biology NN cord-252871-qfrpuy3t 190 5 allow allow VBP cord-252871-qfrpuy3t 190 6 us -PRON- PRP cord-252871-qfrpuy3t 190 7 to to TO cord-252871-qfrpuy3t 190 8 explore explore VB cord-252871-qfrpuy3t 190 9 and and CC cord-252871-qfrpuy3t 190 10 utilize utilize VB cord-252871-qfrpuy3t 190 11 new new JJ cord-252871-qfrpuy3t 190 12 sets set NNS cord-252871-qfrpuy3t 190 13 of of IN cord-252871-qfrpuy3t 190 14 molecular molecular JJ cord-252871-qfrpuy3t 190 15 characters character NNS cord-252871-qfrpuy3t 190 16 to to TO cord-252871-qfrpuy3t 190 17 study study VB cord-252871-qfrpuy3t 190 18 deep deep JJ cord-252871-qfrpuy3t 190 19 evolution evolution NN cord-252871-qfrpuy3t 190 20 . . . cord-252871-qfrpuy3t 191 1 Protein protein NN cord-252871-qfrpuy3t 191 2 function function NN cord-252871-qfrpuy3t 191 3 is be VBZ cord-252871-qfrpuy3t 191 4 usually usually RB cord-252871-qfrpuy3t 191 5 determined determine VBN cord-252871-qfrpuy3t 191 6 directly directly RB cord-252871-qfrpuy3t 191 7 by by IN cord-252871-qfrpuy3t 191 8 the the DT cord-252871-qfrpuy3t 191 9 3D 3d JJ cord-252871-qfrpuy3t 191 10 shape shape NN cord-252871-qfrpuy3t 191 11 of of IN cord-252871-qfrpuy3t 191 12 the the DT cord-252871-qfrpuy3t 191 13 protein protein NN cord-252871-qfrpuy3t 191 14 . . . cord-252871-qfrpuy3t 192 1 This this DT cord-252871-qfrpuy3t 192 2 fact fact NN cord-252871-qfrpuy3t 192 3 constrains constrain VBZ cord-252871-qfrpuy3t 192 4 the the DT cord-252871-qfrpuy3t 192 5 preservation preservation NN cord-252871-qfrpuy3t 192 6 of of IN cord-252871-qfrpuy3t 192 7 protein protein NN cord-252871-qfrpuy3t 192 8 structure structure NN cord-252871-qfrpuy3t 192 9 over over IN cord-252871-qfrpuy3t 192 10 longer long JJR cord-252871-qfrpuy3t 192 11 periods period NNS cord-252871-qfrpuy3t 192 12 of of IN cord-252871-qfrpuy3t 192 13 time time NN cord-252871-qfrpuy3t 192 14 , , , cord-252871-qfrpuy3t 192 15 as as IN cord-252871-qfrpuy3t 192 16 tampering tamper VBG cord-252871-qfrpuy3t 192 17 with with IN cord-252871-qfrpuy3t 192 18 the the DT cord-252871-qfrpuy3t 192 19 structure structure NN cord-252871-qfrpuy3t 192 20 could could MD cord-252871-qfrpuy3t 192 21 lead lead VB cord-252871-qfrpuy3t 192 22 to to IN cord-252871-qfrpuy3t 192 23 loss loss NN cord-252871-qfrpuy3t 192 24 of of IN cord-252871-qfrpuy3t 192 25 function function NN cord-252871-qfrpuy3t 192 26 and and CC cord-252871-qfrpuy3t 192 27 could could MD cord-252871-qfrpuy3t 192 28 be be VB cord-252871-qfrpuy3t 192 29 quite quite RB cord-252871-qfrpuy3t 192 30 damaging damaging JJ cord-252871-qfrpuy3t 192 31 [ [ -LRB- cord-252871-qfrpuy3t 192 32 63 63 CD cord-252871-qfrpuy3t 192 33 , , , cord-252871-qfrpuy3t 192 34 75 75 CD cord-252871-qfrpuy3t 192 35 , , , cord-252871-qfrpuy3t 192 36 76 76 CD cord-252871-qfrpuy3t 192 37 ] ] -RRB- cord-252871-qfrpuy3t 192 38 . . . cord-252871-qfrpuy3t 193 1 As as IN cord-252871-qfrpuy3t 193 2 of of IN cord-252871-qfrpuy3t 193 3 26 26 CD cord-252871-qfrpuy3t 193 4 May May NNP cord-252871-qfrpuy3t 193 5 2020 2020 CD cord-252871-qfrpuy3t 193 6 , , , cord-252871-qfrpuy3t 193 7 there there EX cord-252871-qfrpuy3t 193 8 are~160 are~160 CD cord-252871-qfrpuy3t 193 9 000 000 CD cord-252871-qfrpuy3t 194 1 protein protein JJ cord-252871-qfrpuy3t 194 2 structural structural JJ cord-252871-qfrpuy3t 194 3 entries entry NNS cord-252871-qfrpuy3t 194 4 in in IN cord-252871-qfrpuy3t 194 5 the the DT cord-252871-qfrpuy3t 194 6 RCSB RCSB NNP cord-252871-qfrpuy3t 194 7 Protein Protein NNP cord-252871-qfrpuy3t 194 8 Data Data NNP cord-252871-qfrpuy3t 194 9 Bank Bank NNP cord-252871-qfrpuy3t 194 10 [ [ -LRB- cord-252871-qfrpuy3t 194 11 77 77 CD cord-252871-qfrpuy3t 194 12 ] ] -RRB- cord-252871-qfrpuy3t 194 13 . . . cord-252871-qfrpuy3t 195 1 These these DT cord-252871-qfrpuy3t 195 2 structures structure NNS cord-252871-qfrpuy3t 195 3 correspond correspond VBP cord-252871-qfrpuy3t 195 4 to~1400 to~1400 CD cord-252871-qfrpuy3t 195 5 protein protein NN cord-252871-qfrpuy3t 195 6 folds fold VBZ cord-252871-qfrpuy3t 195 7 [ [ -LRB- cord-252871-qfrpuy3t 195 8 78 78 CD cord-252871-qfrpuy3t 195 9 ] ] -RRB- cord-252871-qfrpuy3t 195 10 , , , cord-252871-qfrpuy3t 195 11 indicating indicate VBG cord-252871-qfrpuy3t 195 12 that that IN cord-252871-qfrpuy3t 195 13 protein protein NN cord-252871-qfrpuy3t 195 14 structure structure NN cord-252871-qfrpuy3t 195 15 space space NN cord-252871-qfrpuy3t 195 16 is be VBZ cord-252871-qfrpuy3t 195 17 relatively relatively RB cord-252871-qfrpuy3t 195 18 well well RB cord-252871-qfrpuy3t 195 19 sampled sample VBN cord-252871-qfrpuy3t 195 20 and and CC cord-252871-qfrpuy3t 195 21 possibly possibly RB cord-252871-qfrpuy3t 195 22 finite finite JJ cord-252871-qfrpuy3t 195 23 [ [ -LRB- cord-252871-qfrpuy3t 195 24 79 79 CD cord-252871-qfrpuy3t 195 25 ] ] -RRB- cord-252871-qfrpuy3t 195 26 . . . cord-252871-qfrpuy3t 196 1 IllergÄrd IllergÄrd NNP cord-252871-qfrpuy3t 196 2 et et NNP cord-252871-qfrpuy3t 196 3 al al NNP cord-252871-qfrpuy3t 196 4 . . . cord-252871-qfrpuy3t 197 1 showed show VBD cord-252871-qfrpuy3t 197 2 that that IN cord-252871-qfrpuy3t 197 3 protein protein NN cord-252871-qfrpuy3t 197 4 structures structure NNS cord-252871-qfrpuy3t 197 5 evolve evolve VBP cord-252871-qfrpuy3t 197 6 at at RB cord-252871-qfrpuy3t 197 7 least least RBS cord-252871-qfrpuy3t 197 8 three three CD cord-252871-qfrpuy3t 197 9 to to TO cord-252871-qfrpuy3t 197 10 ten ten CD cord-252871-qfrpuy3t 197 11 times time NNS cord-252871-qfrpuy3t 197 12 slower slow JJR cord-252871-qfrpuy3t 197 13 than than IN cord-252871-qfrpuy3t 197 14 protein protein NN cord-252871-qfrpuy3t 197 15 sequences sequence NNS cord-252871-qfrpuy3t 197 16 [ [ -LRB- cord-252871-qfrpuy3t 197 17 74 74 CD cord-252871-qfrpuy3t 197 18 ] ] -RRB- cord-252871-qfrpuy3t 197 19 . . . cord-252871-qfrpuy3t 198 1 Protein protein NN cord-252871-qfrpuy3t 198 2 folds fold NNS cord-252871-qfrpuy3t 198 3 are be VBP cord-252871-qfrpuy3t 198 4 thus thus RB cord-252871-qfrpuy3t 198 5 ( ( -LRB- cord-252871-qfrpuy3t 198 6 apparently apparently RB cord-252871-qfrpuy3t 198 7 ) ) -RRB- cord-252871-qfrpuy3t 198 8 advantageous advantageous JJ cord-252871-qfrpuy3t 198 9 as as IN cord-252871-qfrpuy3t 198 10 they -PRON- PRP cord-252871-qfrpuy3t 198 11 are be VBP cord-252871-qfrpuy3t 198 12 remarkably remarkably RB cord-252871-qfrpuy3t 198 13 conserved conserve VBN cord-252871-qfrpuy3t 198 14 across across IN cord-252871-qfrpuy3t 198 15 all all DT cord-252871-qfrpuy3t 198 16 species specie NNS cord-252871-qfrpuy3t 198 17 , , , cord-252871-qfrpuy3t 198 18 ( ( -LRB- cord-252871-qfrpuy3t 198 19 and and CC cord-252871-qfrpuy3t 198 20 even even RB cord-252871-qfrpuy3t 198 21 ) ) -RRB- cord-252871-qfrpuy3t 198 22 viruses virus NNS cord-252871-qfrpuy3t 198 23 , , , cord-252871-qfrpuy3t 198 24 as as IN cord-252871-qfrpuy3t 198 25 revealed reveal VBN cord-252871-qfrpuy3t 198 26 by by IN cord-252871-qfrpuy3t 198 27 their -PRON- PRP$ cord-252871-qfrpuy3t 198 28 use use NN cord-252871-qfrpuy3t 198 29 in in IN cord-252871-qfrpuy3t 198 30 recent recent JJ cord-252871-qfrpuy3t 198 31 studies study NNS cord-252871-qfrpuy3t 198 32 [ [ -LRB- cord-252871-qfrpuy3t 198 33 80 80 CD cord-252871-qfrpuy3t 198 34 , , , cord-252871-qfrpuy3t 198 35 81 81 CD cord-252871-qfrpuy3t 198 36 ] ] -RRB- cord-252871-qfrpuy3t 198 37 . . . cord-252871-qfrpuy3t 199 1 It -PRON- PRP cord-252871-qfrpuy3t 199 2 is be VBZ cord-252871-qfrpuy3t 199 3 possible possible JJ cord-252871-qfrpuy3t 199 4 that that IN cord-252871-qfrpuy3t 199 5 a a DT cord-252871-qfrpuy3t 199 6 large large JJ cord-252871-qfrpuy3t 199 7 number number NN cord-252871-qfrpuy3t 199 8 of of IN cord-252871-qfrpuy3t 199 9 protein protein NN cord-252871-qfrpuy3t 199 10 folds fold NNS cord-252871-qfrpuy3t 199 11 we -PRON- PRP cord-252871-qfrpuy3t 199 12 see see VBP cord-252871-qfrpuy3t 199 13 today today NN cord-252871-qfrpuy3t 199 14 are be VBP cord-252871-qfrpuy3t 199 15 very very RB cord-252871-qfrpuy3t 199 16 ancient ancient JJ cord-252871-qfrpuy3t 199 17 , , , cord-252871-qfrpuy3t 199 18 and and CC cord-252871-qfrpuy3t 199 19 even even RB cord-252871-qfrpuy3t 199 20 predated predate VBD cord-252871-qfrpuy3t 199 21 LUCA LUCA NNP cord-252871-qfrpuy3t 199 22 [ [ -LRB- cord-252871-qfrpuy3t 199 23 37 37 CD cord-252871-qfrpuy3t 199 24 , , , cord-252871-qfrpuy3t 199 25 41 41 CD cord-252871-qfrpuy3t 199 26 ] ] -RRB- cord-252871-qfrpuy3t 199 27 . . . cord-252871-qfrpuy3t 200 1 Their -PRON- PRP$ cord-252871-qfrpuy3t 200 2 use use NN cord-252871-qfrpuy3t 200 3 could could MD cord-252871-qfrpuy3t 200 4 thus thus RB cord-252871-qfrpuy3t 200 5 be be VB cord-252871-qfrpuy3t 200 6 extremely extremely RB cord-252871-qfrpuy3t 200 7 powerful powerful JJ cord-252871-qfrpuy3t 200 8 if if IN cord-252871-qfrpuy3t 200 9 subjected subject VBN cord-252871-qfrpuy3t 200 10 to to TO cord-252871-qfrpuy3t 200 11 careful careful JJ cord-252871-qfrpuy3t 200 12 phylogenomic phylogenomic JJ cord-252871-qfrpuy3t 200 13 and and CC cord-252871-qfrpuy3t 200 14 comparative comparative JJ cord-252871-qfrpuy3t 200 15 analyses analysis NNS cord-252871-qfrpuy3t 200 16 . . . cord-252871-qfrpuy3t 201 1 However however RB cord-252871-qfrpuy3t 201 2 , , , cord-252871-qfrpuy3t 201 3 much much RB cord-252871-qfrpuy3t 201 4 like like IN cord-252871-qfrpuy3t 201 5 the the DT cord-252871-qfrpuy3t 201 6 resistance resistance NN cord-252871-qfrpuy3t 201 7 to to IN cord-252871-qfrpuy3t 201 8 accepting accept VBG cord-252871-qfrpuy3t 201 9 emerging emerge VBG cord-252871-qfrpuy3t 201 10 viewpoints viewpoint NNS cord-252871-qfrpuy3t 201 11 on on IN cord-252871-qfrpuy3t 201 12 viruses virus NNS cord-252871-qfrpuy3t 201 13 , , , cord-252871-qfrpuy3t 201 14 protein protein NN cord-252871-qfrpuy3t 201 15 structures structure NNS cord-252871-qfrpuy3t 201 16 have have VBP cord-252871-qfrpuy3t 201 17 been be VBN cord-252871-qfrpuy3t 201 18 rarely rarely RB cord-252871-qfrpuy3t 201 19 utilized utilize VBN cord-252871-qfrpuy3t 201 20 in in IN cord-252871-qfrpuy3t 201 21 evolutionary evolutionary JJ cord-252871-qfrpuy3t 201 22 studies study NNS cord-252871-qfrpuy3t 201 23 . . . cord-252871-qfrpuy3t 202 1 This this DT cord-252871-qfrpuy3t 202 2 remains remain VBZ cord-252871-qfrpuy3t 202 3 another another DT cord-252871-qfrpuy3t 202 4 major major JJ cord-252871-qfrpuy3t 202 5 roadblock roadblock NN cord-252871-qfrpuy3t 202 6 in in IN cord-252871-qfrpuy3t 202 7 our -PRON- PRP$ cord-252871-qfrpuy3t 202 8 understanding understanding NN cord-252871-qfrpuy3t 202 9 of of IN cord-252871-qfrpuy3t 202 10 virus virus NN cord-252871-qfrpuy3t 202 11 origins origin NNS cord-252871-qfrpuy3t 202 12 and and CC cord-252871-qfrpuy3t 202 13 evolution evolution NN cord-252871-qfrpuy3t 202 14 . . . cord-252871-qfrpuy3t 203 1 Trends trend NNS cord-252871-qfrpuy3t 203 2 in in IN cord-252871-qfrpuy3t 203 3 Microbiology Microbiology NNP cord-252871-qfrpuy3t 203 4 , , , cord-252871-qfrpuy3t 203 5 Month Month NNP cord-252871-qfrpuy3t 203 6 2020 2020 CD cord-252871-qfrpuy3t 203 7 , , , cord-252871-qfrpuy3t 203 8 Vol Vol NNP cord-252871-qfrpuy3t 203 9 . . . cord-252871-qfrpuy3t 204 1 xx xx UH cord-252871-qfrpuy3t 204 2 , , , cord-252871-qfrpuy3t 204 3 No no UH cord-252871-qfrpuy3t 204 4 . . . cord-252871-qfrpuy3t 205 1 xx xx LS cord-252871-qfrpuy3t 205 2 7 7 CD cord-252871-qfrpuy3t 205 3 Ten ten CD cord-252871-qfrpuy3t 205 4 reasons reason NNS cord-252871-qfrpuy3t 205 5 to to TO cord-252871-qfrpuy3t 205 6 exclude exclude VB cord-252871-qfrpuy3t 205 7 viruses virus NNS cord-252871-qfrpuy3t 205 8 from from IN cord-252871-qfrpuy3t 205 9 the the DT cord-252871-qfrpuy3t 205 10 tree tree NN cord-252871-qfrpuy3t 205 11 of of IN cord-252871-qfrpuy3t 205 12 life life NN cord-252871-qfrpuy3t 205 13 To to TO cord-252871-qfrpuy3t 205 14 be be VB cord-252871-qfrpuy3t 205 15 or or CC cord-252871-qfrpuy3t 205 16 not not RB cord-252871-qfrpuy3t 205 17 to to TO cord-252871-qfrpuy3t 205 18 be be VB cord-252871-qfrpuy3t 205 19 alive alive JJ cord-252871-qfrpuy3t 206 1 : : : cord-252871-qfrpuy3t 206 2 How how WRB cord-252871-qfrpuy3t 206 3 recent recent JJ cord-252871-qfrpuy3t 206 4 discoveries discovery NNS cord-252871-qfrpuy3t 206 5 challenge challenge VBP cord-252871-qfrpuy3t 206 6 the the DT cord-252871-qfrpuy3t 206 7 traditional traditional JJ cord-252871-qfrpuy3t 206 8 definitions definition NNS cord-252871-qfrpuy3t 206 9 of of IN cord-252871-qfrpuy3t 206 10 viruses virus NNS cord-252871-qfrpuy3t 206 11 and and CC cord-252871-qfrpuy3t 206 12 life life NN cord-252871-qfrpuy3t 206 13 Viruses virus NNS cord-252871-qfrpuy3t 206 14 as as IN cord-252871-qfrpuy3t 206 15 living living NN cord-252871-qfrpuy3t 206 16 processes process NNS cord-252871-qfrpuy3t 206 17 Open open JJ cord-252871-qfrpuy3t 206 18 questions question NNS cord-252871-qfrpuy3t 206 19 about about IN cord-252871-qfrpuy3t 206 20 giant giant JJ cord-252871-qfrpuy3t 206 21 viruses virus NNS cord-252871-qfrpuy3t 207 1 The the DT cord-252871-qfrpuy3t 207 2 metaphor metaphor NN cord-252871-qfrpuy3t 207 3 that that WDT cord-252871-qfrpuy3t 207 4 viruses virus NNS cord-252871-qfrpuy3t 207 5 are be VBP cord-252871-qfrpuy3t 207 6 living live VBG cord-252871-qfrpuy3t 207 7 is be VBZ cord-252871-qfrpuy3t 207 8 alive alive JJ cord-252871-qfrpuy3t 207 9 and and CC cord-252871-qfrpuy3t 207 10 well well RB cord-252871-qfrpuy3t 207 11 , , , cord-252871-qfrpuy3t 207 12 but but CC cord-252871-qfrpuy3t 207 13 it -PRON- PRP cord-252871-qfrpuy3t 207 14 is be VBZ cord-252871-qfrpuy3t 207 15 no no DT cord-252871-qfrpuy3t 207 16 more more JJR cord-252871-qfrpuy3t 207 17 than than IN cord-252871-qfrpuy3t 207 18 a a DT cord-252871-qfrpuy3t 207 19 metaphor metaphor NN cord-252871-qfrpuy3t 208 1 The the DT cord-252871-qfrpuy3t 208 2 proximal proximal JJ cord-252871-qfrpuy3t 208 3 origin origin NN cord-252871-qfrpuy3t 208 4 of of IN cord-252871-qfrpuy3t 208 5 SARS SARS NNP cord-252871-qfrpuy3t 208 6 - - HYPH cord-252871-qfrpuy3t 208 7 CoV-2 CoV-2 NNP cord-252871-qfrpuy3t 208 8 Dynamic dynamic JJ cord-252871-qfrpuy3t 208 9 genome genome NN cord-252871-qfrpuy3t 208 10 evolution evolution NN cord-252871-qfrpuy3t 208 11 and and CC cord-252871-qfrpuy3t 208 12 complex complex JJ cord-252871-qfrpuy3t 208 13 virocell virocell JJ cord-252871-qfrpuy3t 208 14 metabolism metabolism NN cord-252871-qfrpuy3t 208 15 of of IN cord-252871-qfrpuy3t 208 16 globally globally RB cord-252871-qfrpuy3t 208 17 - - HYPH cord-252871-qfrpuy3t 208 18 distributed distribute VBN cord-252871-qfrpuy3t 208 19 giant giant JJ cord-252871-qfrpuy3t 208 20 viruses virus NNS cord-252871-qfrpuy3t 208 21 Giant giant JJ cord-252871-qfrpuy3t 208 22 virus virus NN cord-252871-qfrpuy3t 208 23 diversity diversity NN cord-252871-qfrpuy3t 208 24 and and CC cord-252871-qfrpuy3t 208 25 host host NN cord-252871-qfrpuy3t 208 26 interactions interaction NNS cord-252871-qfrpuy3t 208 27 through through IN cord-252871-qfrpuy3t 208 28 global global JJ cord-252871-qfrpuy3t 208 29 metagenomics metagenomic NNS cord-252871-qfrpuy3t 209 1 The the DT cord-252871-qfrpuy3t 209 2 good good JJ cord-252871-qfrpuy3t 209 3 viruses virus NNS cord-252871-qfrpuy3t 209 4 : : : cord-252871-qfrpuy3t 210 1 viral viral JJ cord-252871-qfrpuy3t 210 2 mutualistic mutualistic JJ cord-252871-qfrpuy3t 210 3 symbioses symbiose NNS cord-252871-qfrpuy3t 210 4 Move move VB cord-252871-qfrpuy3t 210 5 over over RB cord-252871-qfrpuy3t 210 6 , , , cord-252871-qfrpuy3t 210 7 bacteria bacteria NNS cord-252871-qfrpuy3t 210 8 ! ! . cord-252871-qfrpuy3t 211 1 viruses virus NNS cord-252871-qfrpuy3t 211 2 make make VBP cord-252871-qfrpuy3t 211 3 their -PRON- PRP$ cord-252871-qfrpuy3t 211 4 mark mark NN cord-252871-qfrpuy3t 211 5 as as IN cord-252871-qfrpuy3t 211 6 mutualistic mutualistic JJ cord-252871-qfrpuy3t 211 7 microbial microbial JJ cord-252871-qfrpuy3t 211 8 symbionts symbiont NNS cord-252871-qfrpuy3t 211 9 Giant giant JJ cord-252871-qfrpuy3t 211 10 viruses virus NNS cord-252871-qfrpuy3t 211 11 : : : cord-252871-qfrpuy3t 211 12 The the DT cord-252871-qfrpuy3t 211 13 difficult difficult JJ cord-252871-qfrpuy3t 211 14 breaking breaking NN cord-252871-qfrpuy3t 211 15 of of IN cord-252871-qfrpuy3t 211 16 multiple multiple JJ cord-252871-qfrpuy3t 211 17 epistemological epistemological JJ cord-252871-qfrpuy3t 211 18 barriers barrier NNS cord-252871-qfrpuy3t 211 19 Viruses virus NNS cord-252871-qfrpuy3t 211 20 take take VBP cord-252871-qfrpuy3t 211 21 center center NN cord-252871-qfrpuy3t 211 22 stage stage NN cord-252871-qfrpuy3t 211 23 in in IN cord-252871-qfrpuy3t 211 24 cellular cellular JJ cord-252871-qfrpuy3t 211 25 evolution evolution NN cord-252871-qfrpuy3t 211 26 A a DT cord-252871-qfrpuy3t 211 27 new new JJ cord-252871-qfrpuy3t 211 28 theory theory NN cord-252871-qfrpuy3t 211 29 on on IN cord-252871-qfrpuy3t 211 30 the the DT cord-252871-qfrpuy3t 211 31 origin origin NN cord-252871-qfrpuy3t 211 32 and and CC cord-252871-qfrpuy3t 211 33 the the DT cord-252871-qfrpuy3t 211 34 nature nature NN cord-252871-qfrpuy3t 211 35 of of IN cord-252871-qfrpuy3t 211 36 viruses virus NNS cord-252871-qfrpuy3t 211 37 Logical logical JJ cord-252871-qfrpuy3t 211 38 puzzles puzzle NNS cord-252871-qfrpuy3t 211 39 and and CC cord-252871-qfrpuy3t 211 40 scientific scientific JJ cord-252871-qfrpuy3t 211 41 controversies controversy NNS cord-252871-qfrpuy3t 211 42 : : : cord-252871-qfrpuy3t 211 43 The the DT cord-252871-qfrpuy3t 211 44 nature nature NN cord-252871-qfrpuy3t 211 45 of of IN cord-252871-qfrpuy3t 211 46 species specie NNS cord-252871-qfrpuy3t 211 47 , , , cord-252871-qfrpuy3t 211 48 viruses virus NNS cord-252871-qfrpuy3t 211 49 and and CC cord-252871-qfrpuy3t 211 50 living live VBG cord-252871-qfrpuy3t 211 51 organisms organism NNS cord-252871-qfrpuy3t 212 1 The the DT cord-252871-qfrpuy3t 212 2 transition transition NN cord-252871-qfrpuy3t 212 3 from from IN cord-252871-qfrpuy3t 212 4 live live RB cord-252871-qfrpuy3t 212 5 to to IN cord-252871-qfrpuy3t 212 6 dead dead JJ cord-252871-qfrpuy3t 212 7 : : : cord-252871-qfrpuy3t 212 8 the the DT cord-252871-qfrpuy3t 212 9 nature nature NN cord-252871-qfrpuy3t 212 10 of of IN cord-252871-qfrpuy3t 212 11 filtrable filtrable JJ cord-252871-qfrpuy3t 212 12 viruses virus NNS cord-252871-qfrpuy3t 213 1 The the DT cord-252871-qfrpuy3t 213 2 origin origin NN cord-252871-qfrpuy3t 213 3 and and CC cord-252871-qfrpuy3t 213 4 evolution evolution NN cord-252871-qfrpuy3t 213 5 of of IN cord-252871-qfrpuy3t 213 6 viruses virus NNS cord-252871-qfrpuy3t 213 7 as as IN cord-252871-qfrpuy3t 213 8 molecular molecular JJ cord-252871-qfrpuy3t 213 9 organisms organism NNS cord-252871-qfrpuy3t 213 10 Principles principle NNS cord-252871-qfrpuy3t 213 11 of of IN cord-252871-qfrpuy3t 213 12 classification classification NN cord-252871-qfrpuy3t 213 13 and and CC cord-252871-qfrpuy3t 213 14 nomenclature nomenclature NN cord-252871-qfrpuy3t 213 15 of of IN cord-252871-qfrpuy3t 213 16 viruses virus NNS cord-252871-qfrpuy3t 213 17 Manipulation manipulation NN cord-252871-qfrpuy3t 213 18 of of IN cord-252871-qfrpuy3t 213 19 cellular cellular JJ cord-252871-qfrpuy3t 213 20 syntheses synthesis NNS cord-252871-qfrpuy3t 213 21 and and CC cord-252871-qfrpuy3t 213 22 the the DT cord-252871-qfrpuy3t 213 23 nature nature NN cord-252871-qfrpuy3t 213 24 of of IN cord-252871-qfrpuy3t 213 25 viruses virus NNS cord-252871-qfrpuy3t 214 1 : : : cord-252871-qfrpuy3t 214 2 The the DT cord-252871-qfrpuy3t 214 3 virocell virocell JJ cord-252871-qfrpuy3t 214 4 concept concept NN cord-252871-qfrpuy3t 214 5 Ultrastructural ultrastructural JJ cord-252871-qfrpuy3t 214 6 characterization characterization NN cord-252871-qfrpuy3t 214 7 of of IN cord-252871-qfrpuy3t 214 8 the the DT cord-252871-qfrpuy3t 214 9 giant giant JJ cord-252871-qfrpuy3t 214 10 volcano volcano NN cord-252871-qfrpuy3t 214 11 - - HYPH cord-252871-qfrpuy3t 214 12 like like JJ cord-252871-qfrpuy3t 214 13 virus virus NN cord-252871-qfrpuy3t 214 14 factory factory NN cord-252871-qfrpuy3t 214 15 of of IN cord-252871-qfrpuy3t 214 16 Acanthamoeba Acanthamoeba NNP cord-252871-qfrpuy3t 214 17 polyphaga polyphaga NNP cord-252871-qfrpuy3t 214 18 Mimivirus Mimivirus NNP cord-252871-qfrpuy3t 215 1 The the DT cord-252871-qfrpuy3t 215 2 concept concept NN cord-252871-qfrpuy3t 215 3 of of IN cord-252871-qfrpuy3t 215 4 virus virus NN cord-252871-qfrpuy3t 215 5 Viruses virus NNS cord-252871-qfrpuy3t 215 6 and and CC cord-252871-qfrpuy3t 215 7 genes gene NNS cord-252871-qfrpuy3t 215 8 Redefining redefine VBG cord-252871-qfrpuy3t 215 9 viruses virus NNS cord-252871-qfrpuy3t 215 10 : : : cord-252871-qfrpuy3t 215 11 lessons lesson NNS cord-252871-qfrpuy3t 215 12 from from IN cord-252871-qfrpuy3t 215 13 Mimivirus Mimivirus NNP cord-252871-qfrpuy3t 216 1 The the DT cord-252871-qfrpuy3t 216 2 1.2-megabase 1.2-megabase CD cord-252871-qfrpuy3t 216 3 genome genome NN cord-252871-qfrpuy3t 216 4 sequence sequence NN cord-252871-qfrpuy3t 216 5 of of IN cord-252871-qfrpuy3t 216 6 Mimivirus Mimivirus NNP cord-252871-qfrpuy3t 216 7 Pandoraviruses Pandoraviruses NNP cord-252871-qfrpuy3t 216 8 : : : cord-252871-qfrpuy3t 216 9 amoeba amoeba NN cord-252871-qfrpuy3t 216 10 viruses virus NNS cord-252871-qfrpuy3t 216 11 with with IN cord-252871-qfrpuy3t 216 12 genomes genome NNS cord-252871-qfrpuy3t 216 13 up up IN cord-252871-qfrpuy3t 216 14 to to IN cord-252871-qfrpuy3t 216 15 2.5 2.5 CD cord-252871-qfrpuy3t 216 16 Mb Mb NNS cord-252871-qfrpuy3t 216 17 reaching reach VBG cord-252871-qfrpuy3t 216 18 that that DT cord-252871-qfrpuy3t 216 19 of of IN cord-252871-qfrpuy3t 216 20 parasitic parasitic JJ cord-252871-qfrpuy3t 216 21 eukaryotes eukaryote NNS cord-252871-qfrpuy3t 217 1 In in IN cord-252871-qfrpuy3t 217 2 - - HYPH cord-252871-qfrpuy3t 217 3 depth depth NN cord-252871-qfrpuy3t 217 4 study study NN cord-252871-qfrpuy3t 217 5 of of IN cord-252871-qfrpuy3t 217 6 Mollivirus Mollivirus NNP cord-252871-qfrpuy3t 217 7 sibericum sibericum NNP cord-252871-qfrpuy3t 217 8 , , , cord-252871-qfrpuy3t 217 9 a a DT cord-252871-qfrpuy3t 217 10 new new JJ cord-252871-qfrpuy3t 217 11 30,000-y 30,000-y CD cord-252871-qfrpuy3t 217 12 - - HYPH cord-252871-qfrpuy3t 217 13 old old JJ cord-252871-qfrpuy3t 217 14 giant giant JJ cord-252871-qfrpuy3t 217 15 virus virus NN cord-252871-qfrpuy3t 217 16 infecting infect VBG cord-252871-qfrpuy3t 217 17 Acanthamoeba Acanthamoeba NNP cord-252871-qfrpuy3t 217 18 Complete Complete NNP cord-252871-qfrpuy3t 217 19 genome genome NN cord-252871-qfrpuy3t 217 20 sequence sequence NN cord-252871-qfrpuy3t 217 21 of of IN cord-252871-qfrpuy3t 217 22 ' ' '' cord-252871-qfrpuy3t 217 23 Candidatus Candidatus NNP cord-252871-qfrpuy3t 217 24 Tremblaya Tremblaya NNP cord-252871-qfrpuy3t 217 25 princeps princeps NN cord-252871-qfrpuy3t 217 26 ' ' '' cord-252871-qfrpuy3t 217 27 strain strain NN cord-252871-qfrpuy3t 217 28 PCVAL PCVAL NNP cord-252871-qfrpuy3t 217 29 , , , cord-252871-qfrpuy3t 217 30 an an DT cord-252871-qfrpuy3t 217 31 intriguing intriguing JJ cord-252871-qfrpuy3t 217 32 translational translational JJ cord-252871-qfrpuy3t 217 33 machine machine NN cord-252871-qfrpuy3t 217 34 below below IN cord-252871-qfrpuy3t 217 35 the the DT cord-252871-qfrpuy3t 217 36 living living NN cord-252871-qfrpuy3t 217 37 - - HYPH cord-252871-qfrpuy3t 217 38 cell cell NN cord-252871-qfrpuy3t 217 39 status status NN cord-252871-qfrpuy3t 218 1 Diverse diverse JJ cord-252871-qfrpuy3t 218 2 uncultivated uncultivated JJ cord-252871-qfrpuy3t 218 3 ultra ultra JJ cord-252871-qfrpuy3t 218 4 - - JJ cord-252871-qfrpuy3t 218 5 small small JJ cord-252871-qfrpuy3t 218 6 bacterial bacterial JJ cord-252871-qfrpuy3t 218 7 cells cell NNS cord-252871-qfrpuy3t 218 8 in in IN cord-252871-qfrpuy3t 218 9 groundwater groundwater NN cord-252871-qfrpuy3t 218 10 Chlamydial chlamydial JJ cord-252871-qfrpuy3t 218 11 metabolism metabolism NN cord-252871-qfrpuy3t 218 12 revisited revisit VBD cord-252871-qfrpuy3t 218 13 : : : cord-252871-qfrpuy3t 218 14 Interspecies interspecies JJ cord-252871-qfrpuy3t 218 15 metabolic metabolic JJ cord-252871-qfrpuy3t 218 16 variability variability NN cord-252871-qfrpuy3t 218 17 and and CC cord-252871-qfrpuy3t 218 18 developmental developmental JJ cord-252871-qfrpuy3t 218 19 stagespecific stagespecific JJ cord-252871-qfrpuy3t 218 20 physiologic physiologic JJ cord-252871-qfrpuy3t 218 21 activities activity NNS cord-252871-qfrpuy3t 219 1 Hadaka Hadaka NNP cord-252871-qfrpuy3t 219 2 virus virus NN cord-252871-qfrpuy3t 219 3 1 1 CD cord-252871-qfrpuy3t 219 4 : : : cord-252871-qfrpuy3t 219 5 a a DT cord-252871-qfrpuy3t 219 6 capsidless capsidless NN cord-252871-qfrpuy3t 219 7 elevensegmented elevensegmente VBN cord-252871-qfrpuy3t 219 8 positive positive JJ cord-252871-qfrpuy3t 219 9 - - HYPH cord-252871-qfrpuy3t 219 10 sense sense NN cord-252871-qfrpuy3t 219 11 single single JJ cord-252871-qfrpuy3t 219 12 - - HYPH cord-252871-qfrpuy3t 219 13 stranded strand VBN cord-252871-qfrpuy3t 219 14 RNA RNA NNP cord-252871-qfrpuy3t 219 15 virus virus NN cord-252871-qfrpuy3t 219 16 from from IN cord-252871-qfrpuy3t 219 17 a a DT cord-252871-qfrpuy3t 219 18 phytopathogenic phytopathogenic JJ cord-252871-qfrpuy3t 219 19 fungus fungus NN cord-252871-qfrpuy3t 219 20 Polydnaviruses polydnaviruse NNS cord-252871-qfrpuy3t 219 21 of of IN cord-252871-qfrpuy3t 219 22 parasitic parasitic JJ cord-252871-qfrpuy3t 219 23 wasps wasp NNS cord-252871-qfrpuy3t 219 24 : : : cord-252871-qfrpuy3t 220 1 domestication domestication NN cord-252871-qfrpuy3t 220 2 of of IN cord-252871-qfrpuy3t 220 3 viruses virus NNS cord-252871-qfrpuy3t 220 4 to to TO cord-252871-qfrpuy3t 220 5 act act VB cord-252871-qfrpuy3t 220 6 as as IN cord-252871-qfrpuy3t 220 7 gene gene NN cord-252871-qfrpuy3t 220 8 delivery delivery NN cord-252871-qfrpuy3t 220 9 vectors vector VBZ cord-252871-qfrpuy3t 220 10 Unusual unusual JJ cord-252871-qfrpuy3t 220 11 viral viral JJ cord-252871-qfrpuy3t 220 12 genomes genome NNS cord-252871-qfrpuy3t 220 13 : : : cord-252871-qfrpuy3t 220 14 Mimivirus Mimivirus NNP cord-252871-qfrpuy3t 220 15 and and CC cord-252871-qfrpuy3t 220 16 the the DT cord-252871-qfrpuy3t 220 17 polydnaviruses polydnaviruse NNS cord-252871-qfrpuy3t 221 1 Extracellular extracellular JJ cord-252871-qfrpuy3t 221 2 membrane membrane NN cord-252871-qfrpuy3t 221 3 vesicles vesicle NNS cord-252871-qfrpuy3t 221 4 in in IN cord-252871-qfrpuy3t 221 5 the the DT cord-252871-qfrpuy3t 221 6 three three CD cord-252871-qfrpuy3t 221 7 domains domain NNS cord-252871-qfrpuy3t 221 8 of of IN cord-252871-qfrpuy3t 221 9 life life NN cord-252871-qfrpuy3t 221 10 and and CC cord-252871-qfrpuy3t 221 11 beyond beyond IN cord-252871-qfrpuy3t 221 12 Vesiduction Vesiduction NNP cord-252871-qfrpuy3t 221 13 : : : cord-252871-qfrpuy3t 221 14 the the DT cord-252871-qfrpuy3t 221 15 fourth fourth JJ cord-252871-qfrpuy3t 221 16 way way NN cord-252871-qfrpuy3t 221 17 of of IN cord-252871-qfrpuy3t 221 18 HGT HGT NNP cord-252871-qfrpuy3t 221 19 Structural structural JJ cord-252871-qfrpuy3t 221 20 basis basis NN cord-252871-qfrpuy3t 221 21 of of IN cord-252871-qfrpuy3t 221 22 enzyme enzyme NN cord-252871-qfrpuy3t 221 23 encapsulation encapsulation NN cord-252871-qfrpuy3t 221 24 into into IN cord-252871-qfrpuy3t 221 25 a a DT cord-252871-qfrpuy3t 221 26 bacterial bacterial JJ cord-252871-qfrpuy3t 221 27 nanocompartment nanocompartment NN cord-252871-qfrpuy3t 221 28 Multiple multiple JJ cord-252871-qfrpuy3t 221 29 origins origin NNS cord-252871-qfrpuy3t 221 30 of of IN cord-252871-qfrpuy3t 221 31 viral viral JJ cord-252871-qfrpuy3t 221 32 capsid capsid NN cord-252871-qfrpuy3t 221 33 proteins protein NNS cord-252871-qfrpuy3t 221 34 from from IN cord-252871-qfrpuy3t 221 35 cellular cellular JJ cord-252871-qfrpuy3t 221 36 ancestors ancestor NNS cord-252871-qfrpuy3t 221 37 Identification Identification NNP cord-252871-qfrpuy3t 221 38 of of IN cord-252871-qfrpuy3t 221 39 capsid capsid NN cord-252871-qfrpuy3t 221 40 / / SYM cord-252871-qfrpuy3t 221 41 coat coat NN cord-252871-qfrpuy3t 221 42 related relate VBD cord-252871-qfrpuy3t 221 43 protein protein NN cord-252871-qfrpuy3t 221 44 folds fold NNS cord-252871-qfrpuy3t 221 45 and and CC cord-252871-qfrpuy3t 221 46 their -PRON- PRP$ cord-252871-qfrpuy3t 221 47 utility utility NN cord-252871-qfrpuy3t 221 48 for for IN cord-252871-qfrpuy3t 221 49 virus virus NN cord-252871-qfrpuy3t 221 50 classification classification NN cord-252871-qfrpuy3t 221 51 Untangling untangle VBG cord-252871-qfrpuy3t 221 52 the the DT cord-252871-qfrpuy3t 221 53 origin origin NN cord-252871-qfrpuy3t 221 54 of of IN cord-252871-qfrpuy3t 221 55 viruses virus NNS cord-252871-qfrpuy3t 221 56 and and CC cord-252871-qfrpuy3t 221 57 their -PRON- PRP$ cord-252871-qfrpuy3t 221 58 impact impact NN cord-252871-qfrpuy3t 221 59 on on IN cord-252871-qfrpuy3t 221 60 cellular cellular JJ cord-252871-qfrpuy3t 221 61 evolution evolution NN cord-252871-qfrpuy3t 222 1 The the DT cord-252871-qfrpuy3t 222 2 virophage virophage NN cord-252871-qfrpuy3t 222 3 as as IN cord-252871-qfrpuy3t 222 4 a a DT cord-252871-qfrpuy3t 222 5 unique unique JJ cord-252871-qfrpuy3t 222 6 parasite parasite NN cord-252871-qfrpuy3t 222 7 of of IN cord-252871-qfrpuy3t 222 8 the the DT cord-252871-qfrpuy3t 222 9 giant giant JJ cord-252871-qfrpuy3t 222 10 mimivirus mimivirus NNP cord-252871-qfrpuy3t 222 11 Mimivirus Mimivirus NNP cord-252871-qfrpuy3t 222 12 and and CC cord-252871-qfrpuy3t 222 13 its -PRON- PRP$ cord-252871-qfrpuy3t 222 14 virophage virophage NN cord-252871-qfrpuy3t 223 1 The the DT cord-252871-qfrpuy3t 223 2 two two CD cord-252871-qfrpuy3t 223 3 ages age NNS cord-252871-qfrpuy3t 223 4 of of IN cord-252871-qfrpuy3t 223 5 the the DT cord-252871-qfrpuy3t 223 6 RNA RNA NNP cord-252871-qfrpuy3t 223 7 world world NN cord-252871-qfrpuy3t 223 8 , , , cord-252871-qfrpuy3t 223 9 and and CC cord-252871-qfrpuy3t 223 10 the the DT cord-252871-qfrpuy3t 223 11 transition transition NN cord-252871-qfrpuy3t 223 12 to to IN cord-252871-qfrpuy3t 223 13 the the DT cord-252871-qfrpuy3t 223 14 DNA dna NN cord-252871-qfrpuy3t 223 15 world world NN cord-252871-qfrpuy3t 223 16 : : : cord-252871-qfrpuy3t 223 17 a a DT cord-252871-qfrpuy3t 223 18 story story NN cord-252871-qfrpuy3t 223 19 of of IN cord-252871-qfrpuy3t 223 20 viruses virus NNS cord-252871-qfrpuy3t 223 21 and and CC cord-252871-qfrpuy3t 223 22 cells cell VBZ cord-252871-qfrpuy3t 223 23 A a DT cord-252871-qfrpuy3t 223 24 phylogenomic phylogenomic JJ cord-252871-qfrpuy3t 223 25 datadriven datadriven NNP cord-252871-qfrpuy3t 223 26 exploration exploration NN cord-252871-qfrpuy3t 223 27 of of IN cord-252871-qfrpuy3t 223 28 viral viral JJ cord-252871-qfrpuy3t 223 29 origins origin NNS cord-252871-qfrpuy3t 223 30 and and CC cord-252871-qfrpuy3t 223 31 evolution evolution NN cord-252871-qfrpuy3t 223 32 Pandoravirus Pandoravirus NNP cord-252871-qfrpuy3t 223 33 celtis celtis NN cord-252871-qfrpuy3t 223 34 illustrates illustrate VBZ cord-252871-qfrpuy3t 223 35 the the DT cord-252871-qfrpuy3t 223 36 microevolution microevolution NN cord-252871-qfrpuy3t 223 37 processes process NNS cord-252871-qfrpuy3t 223 38 at at IN cord-252871-qfrpuy3t 223 39 work work NN cord-252871-qfrpuy3t 223 40 in in IN cord-252871-qfrpuy3t 223 41 the the DT cord-252871-qfrpuy3t 223 42 giant giant JJ cord-252871-qfrpuy3t 223 43 Pandoraviridae Pandoraviridae NNP cord-252871-qfrpuy3t 223 44 genomes genome NNS cord-252871-qfrpuy3t 223 45 Diversity diversity NN cord-252871-qfrpuy3t 223 46 and and CC cord-252871-qfrpuy3t 223 47 evolution evolution NN cord-252871-qfrpuy3t 223 48 of of IN cord-252871-qfrpuy3t 223 49 the the DT cord-252871-qfrpuy3t 223 50 emerging emerge VBG cord-252871-qfrpuy3t 223 51 Pandoraviridae Pandoraviridae NNP cord-252871-qfrpuy3t 223 52 family family NN cord-252871-qfrpuy3t 223 53 Structure structure NN cord-252871-qfrpuy3t 223 54 unifies unify VBZ cord-252871-qfrpuy3t 223 55 the the DT cord-252871-qfrpuy3t 223 56 viral viral JJ cord-252871-qfrpuy3t 223 57 universe universe NN cord-252871-qfrpuy3t 223 58 Origin Origin NNP cord-252871-qfrpuy3t 223 59 of of IN cord-252871-qfrpuy3t 223 60 viruses virus NNS cord-252871-qfrpuy3t 223 61 : : : cord-252871-qfrpuy3t 223 62 primordial primordial JJ cord-252871-qfrpuy3t 223 63 replicators replicator NNS cord-252871-qfrpuy3t 223 64 recruiting recruit VBG cord-252871-qfrpuy3t 223 65 capsids capsid NNS cord-252871-qfrpuy3t 223 66 from from IN cord-252871-qfrpuy3t 223 67 hosts host NNS cord-252871-qfrpuy3t 223 68 Evolution Evolution NNP cord-252871-qfrpuy3t 223 69 of of IN cord-252871-qfrpuy3t 223 70 the the DT cord-252871-qfrpuy3t 223 71 large large JJ cord-252871-qfrpuy3t 223 72 nucleocytoplasmic nucleocytoplasmic JJ cord-252871-qfrpuy3t 223 73 DNA dna NN cord-252871-qfrpuy3t 223 74 viruses virus NNS cord-252871-qfrpuy3t 223 75 of of IN cord-252871-qfrpuy3t 223 76 eukaryotes eukaryote NNS cord-252871-qfrpuy3t 223 77 and and CC cord-252871-qfrpuy3t 223 78 convergent convergent JJ cord-252871-qfrpuy3t 223 79 origins origin NNS cord-252871-qfrpuy3t 223 80 of of IN cord-252871-qfrpuy3t 223 81 viral viral JJ cord-252871-qfrpuy3t 223 82 gigantism gigantism NN cord-252871-qfrpuy3t 223 83 Extreme extreme JJ cord-252871-qfrpuy3t 223 84 genome genome NN cord-252871-qfrpuy3t 223 85 reduction reduction NN cord-252871-qfrpuy3t 223 86 in in IN cord-252871-qfrpuy3t 223 87 symbiotic symbiotic JJ cord-252871-qfrpuy3t 223 88 bacteria bacteria NNS cord-252871-qfrpuy3t 223 89 Yaravirus Yaravirus NNP cord-252871-qfrpuy3t 223 90 : : : cord-252871-qfrpuy3t 224 1 A a DT cord-252871-qfrpuy3t 224 2 novel novel JJ cord-252871-qfrpuy3t 224 3 80-nm 80-nm CD cord-252871-qfrpuy3t 224 4 virus virus NN cord-252871-qfrpuy3t 224 5 infecting infect VBG cord-252871-qfrpuy3t 224 6 Acanthamoeba Acanthamoeba NNP cord-252871-qfrpuy3t 224 7 castellanii castellanii NNP cord-252871-qfrpuy3t 224 8 Evolution evolution NN cord-252871-qfrpuy3t 224 9 of of IN cord-252871-qfrpuy3t 224 10 viruses virus NNS cord-252871-qfrpuy3t 224 11 and and CC cord-252871-qfrpuy3t 224 12 cells cell NNS cord-252871-qfrpuy3t 225 1 : : : cord-252871-qfrpuy3t 225 2 do do VBP cord-252871-qfrpuy3t 225 3 we -PRON- PRP cord-252871-qfrpuy3t 225 4 need need VB cord-252871-qfrpuy3t 225 5 a a DT cord-252871-qfrpuy3t 225 6 fourth fourth JJ cord-252871-qfrpuy3t 225 7 domain domain NN cord-252871-qfrpuy3t 225 8 of of IN cord-252871-qfrpuy3t 225 9 life life NN cord-252871-qfrpuy3t 225 10 to to TO cord-252871-qfrpuy3t 225 11 explain explain VB cord-252871-qfrpuy3t 225 12 the the DT cord-252871-qfrpuy3t 225 13 origin origin NN cord-252871-qfrpuy3t 225 14 of of IN cord-252871-qfrpuy3t 225 15 eukaryotes eukaryote NNS cord-252871-qfrpuy3t 225 16 ? ? . cord-252871-qfrpuy3t 226 1 The the DT cord-252871-qfrpuy3t 226 2 tree tree NN cord-252871-qfrpuy3t 226 3 of of IN cord-252871-qfrpuy3t 226 4 one one CD cord-252871-qfrpuy3t 226 5 percent percent NN cord-252871-qfrpuy3t 226 6 Giant Giant NNP cord-252871-qfrpuy3t 226 7 viruses virus NNS cord-252871-qfrpuy3t 226 8 coexisted coexist VBD cord-252871-qfrpuy3t 226 9 with with IN cord-252871-qfrpuy3t 226 10 the the DT cord-252871-qfrpuy3t 226 11 cellular cellular JJ cord-252871-qfrpuy3t 226 12 ancestors ancestor NNS cord-252871-qfrpuy3t 226 13 and and CC cord-252871-qfrpuy3t 226 14 represent represent VBP cord-252871-qfrpuy3t 226 15 a a DT cord-252871-qfrpuy3t 226 16 distinct distinct JJ cord-252871-qfrpuy3t 226 17 supergroup supergroup NN cord-252871-qfrpuy3t 226 18 along along IN cord-252871-qfrpuy3t 226 19 with with IN cord-252871-qfrpuy3t 226 20 superkingdoms superkingdoms NNP cord-252871-qfrpuy3t 226 21 Archaea Archaea NNP cord-252871-qfrpuy3t 226 22 , , , cord-252871-qfrpuy3t 226 23 Bacteria Bacteria NNPS cord-252871-qfrpuy3t 226 24 and and CC cord-252871-qfrpuy3t 226 25 Eukarya Eukarya NNP cord-252871-qfrpuy3t 226 26 Mimivirus Mimivirus NNP cord-252871-qfrpuy3t 226 27 and and CC cord-252871-qfrpuy3t 226 28 the the DT cord-252871-qfrpuy3t 226 29 emerging emerge VBG cord-252871-qfrpuy3t 226 30 concept concept NN cord-252871-qfrpuy3t 226 31 of of IN cord-252871-qfrpuy3t 226 32 ' ' `` cord-252871-qfrpuy3t 226 33 giant giant JJ cord-252871-qfrpuy3t 226 34 ' ' '' cord-252871-qfrpuy3t 226 35 virus virus NN cord-252871-qfrpuy3t 226 36 Endogenous endogenous JJ cord-252871-qfrpuy3t 226 37 viruses virus NNS cord-252871-qfrpuy3t 226 38 : : : cord-252871-qfrpuy3t 227 1 insights insight NNS cord-252871-qfrpuy3t 227 2 into into IN cord-252871-qfrpuy3t 227 3 viral viral JJ cord-252871-qfrpuy3t 227 4 evolution evolution NN cord-252871-qfrpuy3t 227 5 and and CC cord-252871-qfrpuy3t 227 6 impact impact NN cord-252871-qfrpuy3t 227 7 on on IN cord-252871-qfrpuy3t 227 8 host host NN cord-252871-qfrpuy3t 227 9 biology biology NN cord-252871-qfrpuy3t 227 10 Defining define VBG cord-252871-qfrpuy3t 227 11 life life NN cord-252871-qfrpuy3t 227 12 : : : cord-252871-qfrpuy3t 227 13 The the DT cord-252871-qfrpuy3t 227 14 virus virus NN cord-252871-qfrpuy3t 227 15 viewpoint viewpoint NN cord-252871-qfrpuy3t 227 16 Assembly assembly NN cord-252871-qfrpuy3t 227 17 of of IN cord-252871-qfrpuy3t 227 18 a a DT cord-252871-qfrpuy3t 227 19 nucleus nucleus NN cord-252871-qfrpuy3t 227 20 - - HYPH cord-252871-qfrpuy3t 227 21 like like JJ cord-252871-qfrpuy3t 227 22 structure structure NN cord-252871-qfrpuy3t 227 23 during during IN cord-252871-qfrpuy3t 227 24 viral viral JJ cord-252871-qfrpuy3t 227 25 replication replication NN cord-252871-qfrpuy3t 227 26 in in IN cord-252871-qfrpuy3t 227 27 bacteria bacteria NNS cord-252871-qfrpuy3t 227 28 Giant giant JJ cord-252871-qfrpuy3t 227 29 viruses virus NNS cord-252871-qfrpuy3t 227 30 and and CC cord-252871-qfrpuy3t 227 31 the the DT cord-252871-qfrpuy3t 227 32 origin origin NN cord-252871-qfrpuy3t 227 33 of of IN cord-252871-qfrpuy3t 227 34 modern modern JJ cord-252871-qfrpuy3t 227 35 eukaryotes eukaryote NNS cord-252871-qfrpuy3t 228 1 Viral viral JJ cord-252871-qfrpuy3t 228 2 eukaryogenesis eukaryogenesis NNP cord-252871-qfrpuy3t 228 3 : : : cord-252871-qfrpuy3t 228 4 was be VBD cord-252871-qfrpuy3t 228 5 the the DT cord-252871-qfrpuy3t 228 6 ancestor ancestor NN cord-252871-qfrpuy3t 228 7 of of IN cord-252871-qfrpuy3t 228 8 the the DT cord-252871-qfrpuy3t 228 9 nucleus nucleus NN cord-252871-qfrpuy3t 228 10 a a DT cord-252871-qfrpuy3t 228 11 complex complex JJ cord-252871-qfrpuy3t 228 12 DNA dna NN cord-252871-qfrpuy3t 228 13 virus virus NN cord-252871-qfrpuy3t 228 14 ? ? . cord-252871-qfrpuy3t 229 1 The the DT cord-252871-qfrpuy3t 229 2 primary primary JJ cord-252871-qfrpuy3t 229 3 lines line NNS cord-252871-qfrpuy3t 229 4 of of IN cord-252871-qfrpuy3t 229 5 descent descent NN cord-252871-qfrpuy3t 229 6 and and CC cord-252871-qfrpuy3t 229 7 the the DT cord-252871-qfrpuy3t 229 8 universal universal JJ cord-252871-qfrpuy3t 229 9 ancestor ancestor NN cord-252871-qfrpuy3t 230 1 The the DT cord-252871-qfrpuy3t 230 2 path path NN cord-252871-qfrpuy3t 230 3 from from IN cord-252871-qfrpuy3t 230 4 the the DT cord-252871-qfrpuy3t 230 5 RNA RNA NNP cord-252871-qfrpuy3t 230 6 world world NN cord-252871-qfrpuy3t 230 7 Three Three NNP cord-252871-qfrpuy3t 230 8 RNA RNA NNP cord-252871-qfrpuy3t 230 9 cells cell NNS cord-252871-qfrpuy3t 230 10 for for IN cord-252871-qfrpuy3t 230 11 ribosomal ribosomal JJ cord-252871-qfrpuy3t 230 12 lineages lineage NNS cord-252871-qfrpuy3t 230 13 and and CC cord-252871-qfrpuy3t 230 14 three three CD cord-252871-qfrpuy3t 230 15 DNA dna NN cord-252871-qfrpuy3t 230 16 viruses virus NNS cord-252871-qfrpuy3t 230 17 to to TO cord-252871-qfrpuy3t 230 18 replicate replicate VB cord-252871-qfrpuy3t 230 19 their -PRON- PRP$ cord-252871-qfrpuy3t 230 20 genomes genome NNS cord-252871-qfrpuy3t 230 21 : : : cord-252871-qfrpuy3t 230 22 A a DT cord-252871-qfrpuy3t 230 23 hypothesis hypothesis NN cord-252871-qfrpuy3t 230 24 for for IN cord-252871-qfrpuy3t 230 25 the the DT cord-252871-qfrpuy3t 230 26 origin origin NN cord-252871-qfrpuy3t 230 27 of of IN cord-252871-qfrpuy3t 230 28 cellular cellular JJ cord-252871-qfrpuy3t 230 29 domain domain NN cord-252871-qfrpuy3t 230 30 Mimivirus Mimivirus NNP cord-252871-qfrpuy3t 230 31 : : : cord-252871-qfrpuy3t 230 32 The the DT cord-252871-qfrpuy3t 230 33 emerging emerge VBG cord-252871-qfrpuy3t 230 34 paradox paradox NN cord-252871-qfrpuy3t 230 35 of of IN cord-252871-qfrpuy3t 230 36 quasi quasi JJ cord-252871-qfrpuy3t 230 37 - - JJ cord-252871-qfrpuy3t 230 38 autonomous autonomous JJ cord-252871-qfrpuy3t 230 39 viruses virus NNS cord-252871-qfrpuy3t 230 40 Phylogenetic phylogenetic JJ cord-252871-qfrpuy3t 230 41 tree tree NN cord-252871-qfrpuy3t 230 42 building build VBG cord-252871-qfrpuy3t 230 43 in in IN cord-252871-qfrpuy3t 230 44 the the DT cord-252871-qfrpuy3t 230 45 genomic genomic JJ cord-252871-qfrpuy3t 230 46 age age NN cord-252871-qfrpuy3t 230 47 Benefits benefit NNS cord-252871-qfrpuy3t 230 48 of of IN cord-252871-qfrpuy3t 230 49 using use VBG cord-252871-qfrpuy3t 230 50 molecular molecular JJ cord-252871-qfrpuy3t 230 51 structure structure NN cord-252871-qfrpuy3t 230 52 and and CC cord-252871-qfrpuy3t 230 53 abundance abundance NN cord-252871-qfrpuy3t 230 54 in in IN cord-252871-qfrpuy3t 230 55 phylogenomic phylogenomic NNP cord-252871-qfrpuy3t 230 56 analysis analysis NN cord-252871-qfrpuy3t 230 57 Can Can MD cord-252871-qfrpuy3t 230 58 sequence sequence VB cord-252871-qfrpuy3t 230 59 phylogenies phylogeny NNS cord-252871-qfrpuy3t 230 60 safely safely RB cord-252871-qfrpuy3t 230 61 infer infer VBP cord-252871-qfrpuy3t 230 62 the the DT cord-252871-qfrpuy3t 230 63 origin origin NN cord-252871-qfrpuy3t 230 64 of of IN cord-252871-qfrpuy3t 230 65 the the DT cord-252871-qfrpuy3t 230 66 global global JJ cord-252871-qfrpuy3t 230 67 virome virome NN cord-252871-qfrpuy3t 230 68 ? ? . cord-252871-qfrpuy3t 231 1 mBio mBio NNP cord-252871-qfrpuy3t 231 2 Evolution evolution NN cord-252871-qfrpuy3t 231 3 of of IN cord-252871-qfrpuy3t 231 4 a a DT cord-252871-qfrpuy3t 231 5 major major JJ cord-252871-qfrpuy3t 231 6 virion virion NN cord-252871-qfrpuy3t 231 7 protein protein NN cord-252871-qfrpuy3t 231 8 of of IN cord-252871-qfrpuy3t 231 9 the the DT cord-252871-qfrpuy3t 231 10 giant giant JJ cord-252871-qfrpuy3t 231 11 pandoraviruses pandoraviruse NNS cord-252871-qfrpuy3t 231 12 from from IN cord-252871-qfrpuy3t 231 13 an an DT cord-252871-qfrpuy3t 231 14 inactivated inactivate VBN cord-252871-qfrpuy3t 231 15 bacterial bacterial JJ cord-252871-qfrpuy3t 231 16 glycoside glycoside NN cord-252871-qfrpuy3t 231 17 hydrolase hydrolase NN cord-252871-qfrpuy3t 231 18 Testing test VBG cord-252871-qfrpuy3t 231 19 the the DT cord-252871-qfrpuy3t 231 20 hypothesis hypothesis NN cord-252871-qfrpuy3t 231 21 of of IN cord-252871-qfrpuy3t 231 22 common common JJ cord-252871-qfrpuy3t 231 23 ancestry ancestry NN cord-252871-qfrpuy3t 231 24 Arguments argument NNS cord-252871-qfrpuy3t 231 25 reinforcing reinforce VBG cord-252871-qfrpuy3t 231 26 the the DT cord-252871-qfrpuy3t 231 27 three three CD cord-252871-qfrpuy3t 231 28 - - HYPH cord-252871-qfrpuy3t 231 29 domain domain NN cord-252871-qfrpuy3t 231 30 view view NN cord-252871-qfrpuy3t 231 31 of of IN cord-252871-qfrpuy3t 231 32 diversified diversified JJ cord-252871-qfrpuy3t 231 33 cellular cellular JJ cord-252871-qfrpuy3t 231 34 life life NN cord-252871-qfrpuy3t 231 35 Global global JJ cord-252871-qfrpuy3t 231 36 patterns pattern NNS cord-252871-qfrpuy3t 231 37 of of IN cord-252871-qfrpuy3t 231 38 protein protein NN cord-252871-qfrpuy3t 231 39 domain domain NN cord-252871-qfrpuy3t 231 40 gain gain NN cord-252871-qfrpuy3t 231 41 and and CC cord-252871-qfrpuy3t 231 42 loss loss NN cord-252871-qfrpuy3t 231 43 in in IN cord-252871-qfrpuy3t 231 44 superkingdoms superkingdoms NNP cord-252871-qfrpuy3t 232 1 The the DT cord-252871-qfrpuy3t 232 2 dynamics dynamic NNS cord-252871-qfrpuy3t 232 3 and and CC cord-252871-qfrpuy3t 232 4 evolutionary evolutionary JJ cord-252871-qfrpuy3t 232 5 potential potential NN cord-252871-qfrpuy3t 232 6 of of IN cord-252871-qfrpuy3t 232 7 domain domain NN cord-252871-qfrpuy3t 232 8 loss loss NN cord-252871-qfrpuy3t 232 9 and and CC cord-252871-qfrpuy3t 232 10 emergence emergence NN cord-252871-qfrpuy3t 232 11 Rooting root VBG cord-252871-qfrpuy3t 232 12 phylogenies phylogeny NNS cord-252871-qfrpuy3t 232 13 and and CC cord-252871-qfrpuy3t 232 14 the the DT cord-252871-qfrpuy3t 232 15 tree tree NN cord-252871-qfrpuy3t 232 16 of of IN cord-252871-qfrpuy3t 232 17 life life NN cord-252871-qfrpuy3t 232 18 while while IN cord-252871-qfrpuy3t 232 19 minimizing minimize VBG cord-252871-qfrpuy3t 232 20 ad ad FW cord-252871-qfrpuy3t 232 21 hoc hoc FW cord-252871-qfrpuy3t 232 22 and and CC cord-252871-qfrpuy3t 232 23 auxiliary auxiliary JJ cord-252871-qfrpuy3t 232 24 assumptions assumption NNS cord-252871-qfrpuy3t 232 25 Pitfalls pitfall NNS cord-252871-qfrpuy3t 232 26 in in IN cord-252871-qfrpuy3t 232 27 supermatrix supermatrix NNP cord-252871-qfrpuy3t 232 28 phylogenomics phylogenomic NNS cord-252871-qfrpuy3t 232 29 Viral Viral NNP cord-252871-qfrpuy3t 232 30 mutation mutation NN cord-252871-qfrpuy3t 232 31 rates rate NNS cord-252871-qfrpuy3t 233 1 The the DT cord-252871-qfrpuy3t 233 2 puzzle puzzle NN cord-252871-qfrpuy3t 233 3 of of IN cord-252871-qfrpuy3t 233 4 hiv hiv NNP cord-252871-qfrpuy3t 233 5 neutral neutral NNP cord-252871-qfrpuy3t 233 6 and and CC cord-252871-qfrpuy3t 233 7 selective selective JJ cord-252871-qfrpuy3t 233 8 evolution evolution NN cord-252871-qfrpuy3t 233 9 Structure structure NN cord-252871-qfrpuy3t 233 10 is be VBZ cord-252871-qfrpuy3t 233 11 three three CD cord-252871-qfrpuy3t 233 12 to to TO cord-252871-qfrpuy3t 233 13 ten ten CD cord-252871-qfrpuy3t 233 14 times time NNS cord-252871-qfrpuy3t 233 15 more more RBR cord-252871-qfrpuy3t 233 16 conserved conserved JJ cord-252871-qfrpuy3t 233 17 than than IN cord-252871-qfrpuy3t 233 18 sequence sequence NN cord-252871-qfrpuy3t 233 19 - - : cord-252871-qfrpuy3t 233 20 a a DT cord-252871-qfrpuy3t 233 21 study study NN cord-252871-qfrpuy3t 233 22 of of IN cord-252871-qfrpuy3t 233 23 structural structural JJ cord-252871-qfrpuy3t 233 24 response response NN cord-252871-qfrpuy3t 233 25 in in IN cord-252871-qfrpuy3t 233 26 protein protein NN cord-252871-qfrpuy3t 233 27 cores core NNS cord-252871-qfrpuy3t 233 28 Evolution Evolution NNP cord-252871-qfrpuy3t 233 29 of of IN cord-252871-qfrpuy3t 233 30 the the DT cord-252871-qfrpuy3t 233 31 protein protein NN cord-252871-qfrpuy3t 233 32 repertoire repertoire NN cord-252871-qfrpuy3t 234 1 Comparing compare VBG cord-252871-qfrpuy3t 234 2 genomes genome NNS cord-252871-qfrpuy3t 234 3 in in IN cord-252871-qfrpuy3t 234 4 terms term NNS cord-252871-qfrpuy3t 234 5 of of IN cord-252871-qfrpuy3t 234 6 protein protein NN cord-252871-qfrpuy3t 234 7 structure structure NN cord-252871-qfrpuy3t 234 8 : : : cord-252871-qfrpuy3t 234 9 Surveys survey NNS cord-252871-qfrpuy3t 234 10 of of IN cord-252871-qfrpuy3t 234 11 a a DT cord-252871-qfrpuy3t 234 12 finite finite JJ cord-252871-qfrpuy3t 234 13 parts part NNS cord-252871-qfrpuy3t 234 14 list list NN cord-252871-qfrpuy3t 234 15 RCSB RCSB NNP cord-252871-qfrpuy3t 234 16 Protein Protein NNP cord-252871-qfrpuy3t 234 17 Data Data NNP cord-252871-qfrpuy3t 234 18 Bank Bank NNP cord-252871-qfrpuy3t 234 19 : : : cord-252871-qfrpuy3t 234 20 Biological biological JJ cord-252871-qfrpuy3t 234 21 macromolecular macromolecular JJ cord-252871-qfrpuy3t 234 22 structures structure NNS cord-252871-qfrpuy3t 234 23 enabling enable VBG cord-252871-qfrpuy3t 234 24 research research NN cord-252871-qfrpuy3t 234 25 and and CC cord-252871-qfrpuy3t 234 26 education education NN cord-252871-qfrpuy3t 234 27 in in IN cord-252871-qfrpuy3t 234 28 fundamental fundamental JJ cord-252871-qfrpuy3t 234 29 biology biology NN cord-252871-qfrpuy3t 234 30 , , , cord-252871-qfrpuy3t 234 31 biomedicine biomedicine NN cord-252871-qfrpuy3t 234 32 , , , cord-252871-qfrpuy3t 234 33 biotechnology biotechnology NN cord-252871-qfrpuy3t 234 34 and and CC cord-252871-qfrpuy3t 234 35 energy energy NN cord-252871-qfrpuy3t 235 1 The the DT cord-252871-qfrpuy3t 235 2 SCOP SCOP NNP cord-252871-qfrpuy3t 235 3 database database NN cord-252871-qfrpuy3t 235 4 in in IN cord-252871-qfrpuy3t 235 5 2020 2020 CD cord-252871-qfrpuy3t 235 6 : : : cord-252871-qfrpuy3t 235 7 expanded expand VBN cord-252871-qfrpuy3t 235 8 classification classification NN cord-252871-qfrpuy3t 235 9 of of IN cord-252871-qfrpuy3t 235 10 representative representative JJ cord-252871-qfrpuy3t 235 11 family family NN cord-252871-qfrpuy3t 235 12 and and CC cord-252871-qfrpuy3t 235 13 superfamily superfamily NN cord-252871-qfrpuy3t 235 14 domains domain NNS cord-252871-qfrpuy3t 235 15 of of IN cord-252871-qfrpuy3t 235 16 known know VBN cord-252871-qfrpuy3t 235 17 protein protein NN cord-252871-qfrpuy3t 235 18 structures structure NNS cord-252871-qfrpuy3t 236 1 The the DT cord-252871-qfrpuy3t 236 2 origin origin NN cord-252871-qfrpuy3t 236 3 , , , cord-252871-qfrpuy3t 236 4 evolution evolution NN cord-252871-qfrpuy3t 236 5 and and CC cord-252871-qfrpuy3t 236 6 structure structure NN cord-252871-qfrpuy3t 236 7 of of IN cord-252871-qfrpuy3t 236 8 the the DT cord-252871-qfrpuy3t 236 9 protein protein NN cord-252871-qfrpuy3t 236 10 world world NN cord-252871-qfrpuy3t 237 1 The the DT cord-252871-qfrpuy3t 237 2 origin origin NN cord-252871-qfrpuy3t 237 3 and and CC cord-252871-qfrpuy3t 237 4 evolution evolution NN cord-252871-qfrpuy3t 237 5 of of IN cord-252871-qfrpuy3t 237 6 viruses virus NNS cord-252871-qfrpuy3t 237 7 inferred infer VBN cord-252871-qfrpuy3t 237 8 from from IN cord-252871-qfrpuy3t 237 9 fold fold VB cord-252871-qfrpuy3t 237 10 family family NN cord-252871-qfrpuy3t 237 11 structure structure NN cord-252871-qfrpuy3t 237 12 Bacterial bacterial JJ cord-252871-qfrpuy3t 237 13 origin origin NN cord-252871-qfrpuy3t 237 14 and and CC cord-252871-qfrpuy3t 237 15 reductive reductive JJ cord-252871-qfrpuy3t 237 16 evolution evolution NN cord-252871-qfrpuy3t 237 17 of of IN cord-252871-qfrpuy3t 237 18 the the DT cord-252871-qfrpuy3t 237 19 CPR CPR NNP cord-252871-qfrpuy3t 237 20 group group NN cord-252871-qfrpuy3t 237 21 Viral Viral NNP cord-252871-qfrpuy3t 237 22 evolution evolution NN cord-252871-qfrpuy3t 237 23 Primordial primordial JJ cord-252871-qfrpuy3t 237 24 cellular cellular JJ cord-252871-qfrpuy3t 237 25 origins origin NNS cord-252871-qfrpuy3t 237 26 and and CC cord-252871-qfrpuy3t 237 27 late late JJ cord-252871-qfrpuy3t 237 28 adaptation adaptation NN cord-252871-qfrpuy3t 237 29 to to IN cord-252871-qfrpuy3t 237 30 parasitism parasitism NN cord-252871-qfrpuy3t 237 31 Long long JJ cord-252871-qfrpuy3t 237 32 - - HYPH cord-252871-qfrpuy3t 237 33 term term NN cord-252871-qfrpuy3t 237 34 evolution evolution NN cord-252871-qfrpuy3t 237 35 of of IN cord-252871-qfrpuy3t 237 36 viruses virus NNS cord-252871-qfrpuy3t 237 37 : : : cord-252871-qfrpuy3t 237 38 A a DT cord-252871-qfrpuy3t 237 39 Janusfaced Janusfaced NNP cord-252871-qfrpuy3t 237 40 balance balance NN cord-252871-qfrpuy3t 237 41 A a DT cord-252871-qfrpuy3t 237 42 giant giant JJ cord-252871-qfrpuy3t 237 43 virus virus NN cord-252871-qfrpuy3t 237 44 in in IN cord-252871-qfrpuy3t 237 45 amoebae amoebae DT cord-252871-qfrpuy3t 237 46 Phylogenetic phylogenetic JJ cord-252871-qfrpuy3t 237 47 structure structure NN cord-252871-qfrpuy3t 237 48 of of IN cord-252871-qfrpuy3t 237 49 the the DT cord-252871-qfrpuy3t 237 50 prokaryotic prokaryotic JJ cord-252871-qfrpuy3t 237 51 domain domain NN cord-252871-qfrpuy3t 237 52 : : : cord-252871-qfrpuy3t 237 53 the the DT cord-252871-qfrpuy3t 237 54 primary primary JJ cord-252871-qfrpuy3t 237 55 kingdoms kingdom NNS cord-252871-qfrpuy3t 237 56 Towards towards IN cord-252871-qfrpuy3t 237 57 a a DT cord-252871-qfrpuy3t 237 58 natural natural JJ cord-252871-qfrpuy3t 237 59 system system NN cord-252871-qfrpuy3t 237 60 of of IN cord-252871-qfrpuy3t 237 61 organisms organism NNS cord-252871-qfrpuy3t 237 62 : : : cord-252871-qfrpuy3t 237 63 proposal proposal NN cord-252871-qfrpuy3t 237 64 for for IN cord-252871-qfrpuy3t 237 65 the the DT cord-252871-qfrpuy3t 237 66 domains domain NNS cord-252871-qfrpuy3t 237 67 Archaea Archaea NNP cord-252871-qfrpuy3t 237 68 , , , cord-252871-qfrpuy3t 237 69 Bacteria Bacteria NNS cord-252871-qfrpuy3t 237 70 , , , cord-252871-qfrpuy3t 237 71 and and CC cord-252871-qfrpuy3t 237 72 Eucarya Eucarya NNP cord-252871-qfrpuy3t 237 73 Archaea Archaea NNP cord-252871-qfrpuy3t 237 74 - - HYPH cord-252871-qfrpuy3t 237 75 First First NNP cord-252871-qfrpuy3t 237 76 and and CC cord-252871-qfrpuy3t 237 77 the the DT cord-252871-qfrpuy3t 237 78 co co JJ cord-252871-qfrpuy3t 237 79 - - JJ cord-252871-qfrpuy3t 237 80 evolutionary evolutionary JJ cord-252871-qfrpuy3t 237 81 diversification diversification NN cord-252871-qfrpuy3t 237 82 of of IN cord-252871-qfrpuy3t 237 83 domains domain NNS cord-252871-qfrpuy3t 237 84 of of IN cord-252871-qfrpuy3t 237 85 life life NN cord-252871-qfrpuy3t 238 1 Lokiarchaea Lokiarchaea NNP cord-252871-qfrpuy3t 238 2 are be VBP cord-252871-qfrpuy3t 238 3 close close JJ cord-252871-qfrpuy3t 238 4 relatives relative NNS cord-252871-qfrpuy3t 238 5 of of IN cord-252871-qfrpuy3t 238 6 Euryarchaeota Euryarchaeota NNP cord-252871-qfrpuy3t 238 7 , , , cord-252871-qfrpuy3t 238 8 not not RB cord-252871-qfrpuy3t 238 9 bridging bridge VBG cord-252871-qfrpuy3t 238 10 the the DT cord-252871-qfrpuy3t 238 11 gap gap NN cord-252871-qfrpuy3t 238 12 between between IN cord-252871-qfrpuy3t 238 13 prokaryotes prokaryote NNS cord-252871-qfrpuy3t 238 14 and and CC cord-252871-qfrpuy3t 238 15 eukaryotes eukaryote NNS cord-252871-qfrpuy3t 239 1 Asgard Asgard NNP cord-252871-qfrpuy3t 239 2 archaea archaea NNS cord-252871-qfrpuy3t 239 3 do do VBP cord-252871-qfrpuy3t 239 4 not not RB cord-252871-qfrpuy3t 239 5 close close VB cord-252871-qfrpuy3t 239 6 the the DT cord-252871-qfrpuy3t 239 7 debate debate NN cord-252871-qfrpuy3t 239 8 about about IN cord-252871-qfrpuy3t 239 9 the the DT cord-252871-qfrpuy3t 239 10 universal universal JJ cord-252871-qfrpuy3t 239 11 tree tree NN cord-252871-qfrpuy3t 239 12 of of IN cord-252871-qfrpuy3t 239 13 life life NN cord-252871-qfrpuy3t 239 14 topology topology NN cord-252871-qfrpuy3t 239 15 Asgard Asgard NNP cord-252871-qfrpuy3t 239 16 archaea archaea NNS cord-252871-qfrpuy3t 239 17 illuminate illuminate VBP cord-252871-qfrpuy3t 239 18 the the DT cord-252871-qfrpuy3t 239 19 origin origin NN cord-252871-qfrpuy3t 239 20 of of IN cord-252871-qfrpuy3t 239 21 eukaryotic eukaryotic JJ cord-252871-qfrpuy3t 239 22 cellular cellular JJ cord-252871-qfrpuy3t 239 23 complexity complexity NN cord-252871-qfrpuy3t 239 24 Phylogenomics Phylogenomics NNP cord-252871-qfrpuy3t 239 25 provides provide VBZ cord-252871-qfrpuy3t 239 26 robust robust JJ cord-252871-qfrpuy3t 239 27 support support NN cord-252871-qfrpuy3t 239 28 for for IN cord-252871-qfrpuy3t 239 29 a a DT cord-252871-qfrpuy3t 239 30 two two CD cord-252871-qfrpuy3t 239 31 - - HYPH cord-252871-qfrpuy3t 239 32 domains domain NNS cord-252871-qfrpuy3t 239 33 tree tree NN cord-252871-qfrpuy3t 239 34 of of IN cord-252871-qfrpuy3t 239 35 life life NN