id	sid	tid	token	lemma	pos
cord-048322-5eqdrd52	1	1	key	key	JJ
cord-048322-5eqdrd52	1	2	:	:	:
cord-048322-5eqdrd52	1	3	cord-048322	cord-048322	NN
cord-048322-5eqdrd52	1	4	-	-	HYPH
cord-048322-5eqdrd52	1	5	5eqdrd52	5eqdrd52	VBN
cord-048322-5eqdrd52	1	6	authors	author	NNS
cord-048322-5eqdrd52	1	7	:	:	:
cord-048322-5eqdrd52	1	8	Aigner	Aigner	NNP
cord-048322-5eqdrd52	1	9	,	,	,
cord-048322-5eqdrd52	1	10	Achim	Achim	NNP
cord-048322-5eqdrd52	1	11	title	title	NN
cord-048322-5eqdrd52	1	12	:	:	:
cord-048322-5eqdrd52	1	13	Delivery	Delivery	NNP
cord-048322-5eqdrd52	1	14	Systems	Systems	NNPS
cord-048322-5eqdrd52	1	15	for	for	IN
cord-048322-5eqdrd52	1	16	the	the	DT
cord-048322-5eqdrd52	1	17	Direct	Direct	NNP
cord-048322-5eqdrd52	1	18	Application	Application	NNP
cord-048322-5eqdrd52	1	19	of	of	IN
cord-048322-5eqdrd52	1	20	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	1	21	to	to	TO
cord-048322-5eqdrd52	1	22	Induce	induce	VB
cord-048322-5eqdrd52	1	23	RNA	RNA	NNP
cord-048322-5eqdrd52	1	24	Interference	Interference	NNP
cord-048322-5eqdrd52	1	25	(	(	-LRB-
cord-048322-5eqdrd52	1	26	RNAi	RNAi	NNP
cord-048322-5eqdrd52	1	27	)	)	-RRB-
cord-048322-5eqdrd52	2	1	In	in	IN
cord-048322-5eqdrd52	2	2	Vivo	Vivo	NNP
cord-048322-5eqdrd52	2	3	date	date	NN
cord-048322-5eqdrd52	2	4	:	:	:
cord-048322-5eqdrd52	2	5	2006	2006	CD
cord-048322-5eqdrd52	2	6	-	-	HYPH
cord-048322-5eqdrd52	2	7	05	05	CD
cord-048322-5eqdrd52	2	8	-	-	SYM
cord-048322-5eqdrd52	2	9	18	18	CD
cord-048322-5eqdrd52	2	10	journal	journal	NN
cord-048322-5eqdrd52	2	11	:	:	:
cord-048322-5eqdrd52	2	12	J	J	NNP
cord-048322-5eqdrd52	2	13	Biomed	Biomed	NNP
cord-048322-5eqdrd52	2	14	Biotechnol	Biotechnol	NNP
cord-048322-5eqdrd52	2	15	DOI	DOI	NNP
cord-048322-5eqdrd52	2	16	:	:	:
cord-048322-5eqdrd52	2	17	10.1155	10.1155	CD
cord-048322-5eqdrd52	3	1	/jbb/2006/71659	/jbb/2006/71659	NFP
cord-048322-5eqdrd52	3	2	sha	sha	NNP
cord-048322-5eqdrd52	3	3	:	:	:
cord-048322-5eqdrd52	3	4	f4d18f2beafa875cd4e30a9a237a64b9d3110856	f4d18f2beafa875cd4e30a9a237a64b9d3110856	NNP
cord-048322-5eqdrd52	3	5	doc_id	doc_id	CD
cord-048322-5eqdrd52	3	6	:	:	:
cord-048322-5eqdrd52	3	7	48322	48322	CD
cord-048322-5eqdrd52	3	8	cord_uid	cord_uid	FW
cord-048322-5eqdrd52	3	9	:	:	:
cord-048322-5eqdrd52	4	1	5eqdrd52	5eqdrd52	CD
cord-048322-5eqdrd52	4	2	RNA	RNA	NNP
cord-048322-5eqdrd52	4	3	interference	interference	NN
cord-048322-5eqdrd52	4	4	(	(	-LRB-
cord-048322-5eqdrd52	4	5	RNAi	RNAi	NNP
cord-048322-5eqdrd52	4	6	)	)	-RRB-
cord-048322-5eqdrd52	4	7	is	be	VBZ
cord-048322-5eqdrd52	4	8	a	a	DT
cord-048322-5eqdrd52	4	9	powerful	powerful	JJ
cord-048322-5eqdrd52	4	10	method	method	NN
cord-048322-5eqdrd52	4	11	for	for	IN
cord-048322-5eqdrd52	4	12	specific	specific	JJ
cord-048322-5eqdrd52	4	13	gene	gene	NN
cord-048322-5eqdrd52	4	14	silencing	silencing	NN
cord-048322-5eqdrd52	4	15	which	which	WDT
cord-048322-5eqdrd52	4	16	may	may	MD
cord-048322-5eqdrd52	4	17	also	also	RB
cord-048322-5eqdrd52	4	18	lead	lead	VB
cord-048322-5eqdrd52	4	19	to	to	IN
cord-048322-5eqdrd52	4	20	promising	promising	JJ
cord-048322-5eqdrd52	4	21	novel	novel	JJ
cord-048322-5eqdrd52	4	22	therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	4	23	strategies	strategy	NNS
cord-048322-5eqdrd52	4	24	.	.	.
cord-048322-5eqdrd52	5	1	It	-PRON-	PRP
cord-048322-5eqdrd52	5	2	is	be	VBZ
cord-048322-5eqdrd52	5	3	mediated	mediate	VBN
cord-048322-5eqdrd52	5	4	through	through	IN
cord-048322-5eqdrd52	5	5	small	small	JJ
cord-048322-5eqdrd52	5	6	interfering	interfere	VBG
cord-048322-5eqdrd52	5	7	RNAs	rna	NNS
cord-048322-5eqdrd52	5	8	(	(	-LRB-
cord-048322-5eqdrd52	5	9	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	5	10	)	)	-RRB-
cord-048322-5eqdrd52	5	11	which	which	WDT
cord-048322-5eqdrd52	5	12	sequence	sequence	NN
cord-048322-5eqdrd52	5	13	-	-	:
cord-048322-5eqdrd52	5	14	specifically	specifically	RB
cord-048322-5eqdrd52	5	15	trigger	trigger	VB
cord-048322-5eqdrd52	5	16	the	the	DT
cord-048322-5eqdrd52	5	17	cleavage	cleavage	NN
cord-048322-5eqdrd52	5	18	and	and	CC
cord-048322-5eqdrd52	5	19	subsequent	subsequent	JJ
cord-048322-5eqdrd52	5	20	degradation	degradation	NN
cord-048322-5eqdrd52	5	21	of	of	IN
cord-048322-5eqdrd52	5	22	their	-PRON-	PRP$
cord-048322-5eqdrd52	5	23	target	target	NN
cord-048322-5eqdrd52	5	24	mRNA	mrna	NN
cord-048322-5eqdrd52	5	25	.	.	.
cord-048322-5eqdrd52	6	1	One	one	CD
cord-048322-5eqdrd52	6	2	critical	critical	JJ
cord-048322-5eqdrd52	6	3	factor	factor	NN
cord-048322-5eqdrd52	6	4	is	be	VBZ
cord-048322-5eqdrd52	6	5	the	the	DT
cord-048322-5eqdrd52	6	6	ability	ability	NN
cord-048322-5eqdrd52	6	7	to	to	TO
cord-048322-5eqdrd52	6	8	deliver	deliver	VB
cord-048322-5eqdrd52	6	9	intact	intact	JJ
cord-048322-5eqdrd52	6	10	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	6	11	into	into	IN
cord-048322-5eqdrd52	6	12	target	target	NN
cord-048322-5eqdrd52	6	13	cells	cell	NNS
cord-048322-5eqdrd52	6	14	/	/	SYM
cord-048322-5eqdrd52	6	15	organs	organ	NNS
cord-048322-5eqdrd52	6	16	in	in	IN
cord-048322-5eqdrd52	6	17	vivo	vivo	NN
cord-048322-5eqdrd52	6	18	.	.	.
cord-048322-5eqdrd52	7	1	This	this	DT
cord-048322-5eqdrd52	7	2	review	review	NN
cord-048322-5eqdrd52	7	3	highlights	highlight	VBZ
cord-048322-5eqdrd52	7	4	the	the	DT
cord-048322-5eqdrd52	7	5	mechanism	mechanism	NN
cord-048322-5eqdrd52	7	6	of	of	IN
cord-048322-5eqdrd52	7	7	RNAi	RNAi	NNP
cord-048322-5eqdrd52	7	8	and	and	CC
cord-048322-5eqdrd52	7	9	the	the	DT
cord-048322-5eqdrd52	7	10	guidelines	guideline	NNS
cord-048322-5eqdrd52	7	11	for	for	IN
cord-048322-5eqdrd52	7	12	the	the	DT
cord-048322-5eqdrd52	7	13	design	design	NN
cord-048322-5eqdrd52	7	14	of	of	IN
cord-048322-5eqdrd52	7	15	optimal	optimal	JJ
cord-048322-5eqdrd52	7	16	siRNAs	sirna	NNS
cord-048322-5eqdrd52	7	17	.	.	.
cord-048322-5eqdrd52	8	1	It	-PRON-	PRP
cord-048322-5eqdrd52	8	2	gives	give	VBZ
cord-048322-5eqdrd52	8	3	an	an	DT
cord-048322-5eqdrd52	8	4	overview	overview	NN
cord-048322-5eqdrd52	8	5	of	of	IN
cord-048322-5eqdrd52	8	6	studies	study	NNS
cord-048322-5eqdrd52	8	7	based	base	VBN
cord-048322-5eqdrd52	8	8	on	on	IN
cord-048322-5eqdrd52	8	9	the	the	DT
cord-048322-5eqdrd52	8	10	systemic	systemic	JJ
cord-048322-5eqdrd52	8	11	or	or	CC
cord-048322-5eqdrd52	8	12	local	local	JJ
cord-048322-5eqdrd52	8	13	application	application	NN
cord-048322-5eqdrd52	8	14	of	of	IN
cord-048322-5eqdrd52	8	15	naked	naked	JJ
cord-048322-5eqdrd52	8	16	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	8	17	or	or	CC
cord-048322-5eqdrd52	8	18	the	the	DT
cord-048322-5eqdrd52	8	19	use	use	NN
cord-048322-5eqdrd52	8	20	of	of	IN
cord-048322-5eqdrd52	8	21	various	various	JJ
cord-048322-5eqdrd52	8	22	nonviral	nonviral	JJ
cord-048322-5eqdrd52	8	23	siRNA	siRNA	NNP
cord-048322-5eqdrd52	8	24	delivery	delivery	NN
cord-048322-5eqdrd52	8	25	systems	system	NNS
cord-048322-5eqdrd52	8	26	.	.	.
cord-048322-5eqdrd52	9	1	One	one	CD
cord-048322-5eqdrd52	9	2	promising	promising	JJ
cord-048322-5eqdrd52	9	3	avenue	avenue	NN
cord-048322-5eqdrd52	9	4	is	be	VBZ
cord-048322-5eqdrd52	9	5	the	the	DT
cord-048322-5eqdrd52	9	6	the	the	DT
cord-048322-5eqdrd52	9	7	complexation	complexation	NN
cord-048322-5eqdrd52	9	8	of	of	IN
cord-048322-5eqdrd52	9	9	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	9	10	with	with	IN
cord-048322-5eqdrd52	9	11	the	the	DT
cord-048322-5eqdrd52	9	12	polyethylenimine	polyethylenimine	NNP
cord-048322-5eqdrd52	9	13	(	(	-LRB-
cord-048322-5eqdrd52	9	14	PEI	PEI	NNP
cord-048322-5eqdrd52	9	15	)	)	-RRB-
cord-048322-5eqdrd52	9	16	,	,	,
cord-048322-5eqdrd52	9	17	which	which	WDT
cord-048322-5eqdrd52	9	18	efficiently	efficiently	RB
cord-048322-5eqdrd52	9	19	stabilizes	stabilize	VBZ
cord-048322-5eqdrd52	9	20	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	9	21	and	and	CC
cord-048322-5eqdrd52	9	22	,	,	,
cord-048322-5eqdrd52	9	23	upon	upon	IN
cord-048322-5eqdrd52	9	24	systemic	systemic	JJ
cord-048322-5eqdrd52	9	25	administration	administration	NN
cord-048322-5eqdrd52	9	26	,	,	,
cord-048322-5eqdrd52	9	27	leads	lead	VBZ
cord-048322-5eqdrd52	9	28	to	to	IN
cord-048322-5eqdrd52	9	29	the	the	DT
cord-048322-5eqdrd52	9	30	delivery	delivery	NN
cord-048322-5eqdrd52	9	31	of	of	IN
cord-048322-5eqdrd52	9	32	the	the	DT
cord-048322-5eqdrd52	9	33	intact	intact	JJ
cord-048322-5eqdrd52	9	34	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	9	35	into	into	IN
cord-048322-5eqdrd52	9	36	different	different	JJ
cord-048322-5eqdrd52	9	37	organs	organ	NNS
cord-048322-5eqdrd52	9	38	.	.	.
cord-048322-5eqdrd52	10	1	The	the	DT
cord-048322-5eqdrd52	10	2	antitumorigenic	antitumorigenic	JJ
cord-048322-5eqdrd52	10	3	effects	effect	NNS
cord-048322-5eqdrd52	10	4	of	of	IN
cord-048322-5eqdrd52	10	5	PEI	PEI	NNP
cord-048322-5eqdrd52	10	6	/	/	SYM
cord-048322-5eqdrd52	10	7	siRNA	siRNA	NNP
cord-048322-5eqdrd52	10	8	-	-	HYPH
cord-048322-5eqdrd52	10	9	mediated	mediate	VBN
cord-048322-5eqdrd52	10	10	in	in	IN
cord-048322-5eqdrd52	10	11	vivo	vivo	NN
cord-048322-5eqdrd52	10	12	gene	gene	NN
cord-048322-5eqdrd52	10	13	-	-	HYPH
cord-048322-5eqdrd52	10	14	targeting	targeting	NN
cord-048322-5eqdrd52	10	15	of	of	IN
cord-048322-5eqdrd52	10	16	tumor	tumor	NN
cord-048322-5eqdrd52	10	17	-	-	HYPH
cord-048322-5eqdrd52	10	18	relevant	relevant	JJ
cord-048322-5eqdrd52	10	19	proteins	protein	NNS
cord-048322-5eqdrd52	10	20	like	like	IN
cord-048322-5eqdrd52	10	21	in	in	IN
cord-048322-5eqdrd52	10	22	mouse	mouse	NN
cord-048322-5eqdrd52	10	23	tumor	tumor	NN
cord-048322-5eqdrd52	10	24	xenograft	xenograft	NN
cord-048322-5eqdrd52	10	25	models	model	NNS
cord-048322-5eqdrd52	10	26	are	be	VBP
cord-048322-5eqdrd52	10	27	described	describe	VBN
cord-048322-5eqdrd52	10	28	.	.	.
cord-048322-5eqdrd52	11	1	Altered	altered	JJ
cord-048322-5eqdrd52	11	2	expression	expression	NN
cord-048322-5eqdrd52	11	3	levels	level	NNS
cord-048322-5eqdrd52	11	4	of	of	IN
cord-048322-5eqdrd52	11	5	certain	certain	JJ
cord-048322-5eqdrd52	11	6	genes	gene	NNS
cord-048322-5eqdrd52	11	7	play	play	VBP
cord-048322-5eqdrd52	11	8	a	a	DT
cord-048322-5eqdrd52	11	9	pivotal	pivotal	JJ
cord-048322-5eqdrd52	11	10	role	role	NN
cord-048322-5eqdrd52	11	11	in	in	IN
cord-048322-5eqdrd52	11	12	several	several	JJ
cord-048322-5eqdrd52	11	13	pathological	pathological	JJ
cord-048322-5eqdrd52	11	14	conditions	condition	NNS
cord-048322-5eqdrd52	11	15	.	.	.
cord-048322-5eqdrd52	12	1	For	for	IN
cord-048322-5eqdrd52	12	2	example	example	NN
cord-048322-5eqdrd52	12	3	,	,	,
cord-048322-5eqdrd52	12	4	in	in	IN
cord-048322-5eqdrd52	12	5	many	many	JJ
cord-048322-5eqdrd52	12	6	cancers	cancer	NNS
cord-048322-5eqdrd52	12	7	the	the	DT
cord-048322-5eqdrd52	12	8	upregulation	upregulation	NN
cord-048322-5eqdrd52	12	9	of	of	IN
cord-048322-5eqdrd52	12	10	certain	certain	JJ
cord-048322-5eqdrd52	12	11	growth	growth	NN
cord-048322-5eqdrd52	12	12	factors	factor	NNS
cord-048322-5eqdrd52	12	13	or	or	CC
cord-048322-5eqdrd52	12	14	growth	growth	NN
cord-048322-5eqdrd52	12	15	factor	factor	NN
cord-048322-5eqdrd52	12	16	receptors	receptor	NNS
cord-048322-5eqdrd52	12	17	,	,	,
cord-048322-5eqdrd52	12	18	or	or	CC
cord-048322-5eqdrd52	12	19	the	the	DT
cord-048322-5eqdrd52	12	20	deregulation	deregulation	NN
cord-048322-5eqdrd52	12	21	of	of	IN
cord-048322-5eqdrd52	12	22	intracellular	intracellular	JJ
cord-048322-5eqdrd52	12	23	signal	signal	NN
cord-048322-5eqdrd52	12	24	transduction	transduction	NN
cord-048322-5eqdrd52	12	25	pathways	pathway	NNS
cord-048322-5eqdrd52	12	26	,	,	,
cord-048322-5eqdrd52	12	27	represents	represent	VBZ
cord-048322-5eqdrd52	12	28	key	key	JJ
cord-048322-5eqdrd52	12	29	elements	element	NNS
cord-048322-5eqdrd52	12	30	in	in	IN
cord-048322-5eqdrd52	12	31	the	the	DT
cord-048322-5eqdrd52	12	32	process	process	NN
cord-048322-5eqdrd52	12	33	of	of	IN
cord-048322-5eqdrd52	12	34	malignant	malignant	JJ
cord-048322-5eqdrd52	12	35	transformation	transformation	NN
cord-048322-5eqdrd52	12	36	and	and	CC
cord-048322-5eqdrd52	12	37	progression	progression	NN
cord-048322-5eqdrd52	12	38	of	of	IN
cord-048322-5eqdrd52	12	39	normal	normal	JJ
cord-048322-5eqdrd52	12	40	cells	cell	NNS
cord-048322-5eqdrd52	12	41	towards	towards	IN
cord-048322-5eqdrd52	12	42	tumor	tumor	NN
cord-048322-5eqdrd52	12	43	cells	cell	NNS
cord-048322-5eqdrd52	12	44	leading	lead	VBG
cord-048322-5eqdrd52	12	45	to	to	IN
cord-048322-5eqdrd52	12	46	uncontrolled	uncontrolled	JJ
cord-048322-5eqdrd52	12	47	proliferation	proliferation	NN
cord-048322-5eqdrd52	12	48	and	and	CC
cord-048322-5eqdrd52	12	49	decreased	decrease	VBD
cord-048322-5eqdrd52	12	50	apoptosis	apoptosis	NN
cord-048322-5eqdrd52	12	51	.	.	.
cord-048322-5eqdrd52	13	1	Since	since	IN
cord-048322-5eqdrd52	13	2	these	these	DT
cord-048322-5eqdrd52	13	3	processes	process	NNS
cord-048322-5eqdrd52	13	4	may	may	MD
cord-048322-5eqdrd52	13	5	result	result	VB
cord-048322-5eqdrd52	13	6	in	in	IN
cord-048322-5eqdrd52	13	7	the	the	DT
cord-048322-5eqdrd52	13	8	direct	direct	JJ
cord-048322-5eqdrd52	13	9	,	,	,
cord-048322-5eqdrd52	13	10	autocrine	autocrine	JJ
cord-048322-5eqdrd52	13	11	stimulation	stimulation	NN
cord-048322-5eqdrd52	13	12	of	of	IN
cord-048322-5eqdrd52	13	13	the	the	DT
cord-048322-5eqdrd52	13	14	tumor	tumor	NN
cord-048322-5eqdrd52	13	15	cell	cell	NN
cord-048322-5eqdrd52	13	16	itself	-PRON-	PRP
cord-048322-5eqdrd52	13	17	as	as	RB
cord-048322-5eqdrd52	13	18	well	well	RB
cord-048322-5eqdrd52	13	19	as	as	IN
cord-048322-5eqdrd52	13	20	the	the	DT
cord-048322-5eqdrd52	13	21	paracrine	paracrine	JJ
cord-048322-5eqdrd52	13	22	stimulation	stimulation	NN
cord-048322-5eqdrd52	13	23	of	of	IN
cord-048322-5eqdrd52	13	24	other	other	JJ
cord-048322-5eqdrd52	13	25	cells	cell	NNS
cord-048322-5eqdrd52	13	26	,	,	,
cord-048322-5eqdrd52	13	27	including	include	VBG
cord-048322-5eqdrd52	13	28	the	the	DT
cord-048322-5eqdrd52	13	29	stimulation	stimulation	NN
cord-048322-5eqdrd52	13	30	of	of	IN
cord-048322-5eqdrd52	13	31	tumor	tumor	NN
cord-048322-5eqdrd52	13	32	-	-	HYPH
cord-048322-5eqdrd52	13	33	angiogenesis	angiogenesis	NN
cord-048322-5eqdrd52	13	34	,	,	,
cord-048322-5eqdrd52	13	35	many	many	JJ
cord-048322-5eqdrd52	13	36	novel	novel	JJ
cord-048322-5eqdrd52	13	37	therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	13	38	strategies	strategy	NNS
cord-048322-5eqdrd52	13	39	focus	focus	VBP
cord-048322-5eqdrd52	13	40	on	on	IN
cord-048322-5eqdrd52	13	41	the	the	DT
cord-048322-5eqdrd52	13	42	reversal	reversal	NN
cord-048322-5eqdrd52	13	43	of	of	IN
cord-048322-5eqdrd52	13	44	this	this	DT
cord-048322-5eqdrd52	13	45	effect	effect	NN
cord-048322-5eqdrd52	13	46	,	,	,
cord-048322-5eqdrd52	13	47	that	that	RB
cord-048322-5eqdrd52	13	48	is	is	RB
cord-048322-5eqdrd52	13	49	,	,	,
cord-048322-5eqdrd52	13	50	the	the	DT
cord-048322-5eqdrd52	13	51	inhibition	inhibition	NN
cord-048322-5eqdrd52	13	52	of	of	IN
cord-048322-5eqdrd52	13	53	these	these	DT
cord-048322-5eqdrd52	13	54	proteins	protein	NNS
cord-048322-5eqdrd52	13	55	or	or	CC
cord-048322-5eqdrd52	13	56	the	the	DT
cord-048322-5eqdrd52	13	57	downregulation	downregulation	NN
cord-048322-5eqdrd52	13	58	of	of	IN
cord-048322-5eqdrd52	13	59	their	-PRON-	PRP$
cord-048322-5eqdrd52	13	60	expression	expression	NN
cord-048322-5eqdrd52	13	61	.	.	.
cord-048322-5eqdrd52	14	1	Likewise	likewise	RB
cord-048322-5eqdrd52	14	2	,	,	,
cord-048322-5eqdrd52	14	3	several	several	JJ
cord-048322-5eqdrd52	14	4	other	other	JJ
cord-048322-5eqdrd52	14	5	diseases	disease	NNS
cord-048322-5eqdrd52	14	6	have	have	VBP
cord-048322-5eqdrd52	14	7	been	be	VBN
cord-048322-5eqdrd52	14	8	firmly	firmly	RB
cord-048322-5eqdrd52	14	9	linked	link	VBN
cord-048322-5eqdrd52	14	10	to	to	IN
cord-048322-5eqdrd52	14	11	the	the	DT
cord-048322-5eqdrd52	14	12	(	(	-LRB-
cord-048322-5eqdrd52	14	13	over-)expression	over-)expression	NN
cord-048322-5eqdrd52	14	14	of	of	IN
cord-048322-5eqdrd52	14	15	endogenous	endogenous	JJ
cord-048322-5eqdrd52	14	16	wildtype	wildtype	NN
cord-048322-5eqdrd52	14	17	or	or	CC
cord-048322-5eqdrd52	14	18	mutated	mutate	VBN
cord-048322-5eqdrd52	14	19	genes	gene	NNS
cord-048322-5eqdrd52	14	20	.	.	.
cord-048322-5eqdrd52	15	1	Taken	take	VBN
cord-048322-5eqdrd52	15	2	together	together	RB
cord-048322-5eqdrd52	15	3	,	,	,
cord-048322-5eqdrd52	15	4	in	in	IN
cord-048322-5eqdrd52	15	5	addition	addition	NN
cord-048322-5eqdrd52	15	6	to	to	IN
cord-048322-5eqdrd52	15	7	strategies	strategy	NNS
cord-048322-5eqdrd52	15	8	based	base	VBN
cord-048322-5eqdrd52	15	9	on	on	IN
cord-048322-5eqdrd52	15	10	the	the	DT
cord-048322-5eqdrd52	15	11	inhibition	inhibition	NN
cord-048322-5eqdrd52	15	12	of	of	IN
cord-048322-5eqdrd52	15	13	target	target	NN
cord-048322-5eqdrd52	15	14	proteins	protein	NNS
cord-048322-5eqdrd52	15	15	,	,	,
cord-048322-5eqdrd52	15	16	for	for	IN
cord-048322-5eqdrd52	15	17	example	example	NN
cord-048322-5eqdrd52	15	18	,	,	,
cord-048322-5eqdrd52	15	19	by	by	IN
cord-048322-5eqdrd52	15	20	low	low	JJ
cord-048322-5eqdrd52	15	21	molecular	molecular	JJ
cord-048322-5eqdrd52	15	22	weight	weight	NN
cord-048322-5eqdrd52	15	23	inhibitors	inhibitor	NNS
cord-048322-5eqdrd52	15	24	or	or	CC
cord-048322-5eqdrd52	15	25	inhibitory	inhibitory	JJ
cord-048322-5eqdrd52	15	26	antibodies	antibody	NNS
cord-048322-5eqdrd52	15	27	,	,	,
cord-048322-5eqdrd52	15	28	this	this	DT
cord-048322-5eqdrd52	15	29	opens	open	VBZ
cord-048322-5eqdrd52	15	30	an	an	DT
cord-048322-5eqdrd52	15	31	avenue	avenue	NN
cord-048322-5eqdrd52	15	32	to	to	IN
cord-048322-5eqdrd52	15	33	gene	gene	NN
cord-048322-5eqdrd52	15	34	-	-	HYPH
cord-048322-5eqdrd52	15	35	targeting	target	VBG
cord-048322-5eqdrd52	15	36	approaches	approach	NNS
cord-048322-5eqdrd52	15	37	aiming	aim	VBG
cord-048322-5eqdrd52	15	38	at	at	IN
cord-048322-5eqdrd52	15	39	decreased	decrease	VBN
cord-048322-5eqdrd52	15	40	expression	expression	NN
cord-048322-5eqdrd52	15	41	of	of	IN
cord-048322-5eqdrd52	15	42	the	the	DT
cord-048322-5eqdrd52	15	43	respective	respective	JJ
cord-048322-5eqdrd52	15	44	gene	gene	NN
cord-048322-5eqdrd52	15	45	.	.	.
cord-048322-5eqdrd52	16	1	The	the	DT
cord-048322-5eqdrd52	16	2	first	first	JJ
cord-048322-5eqdrd52	16	3	method	method	NN
cord-048322-5eqdrd52	16	4	to	to	TO
cord-048322-5eqdrd52	16	5	be	be	VB
cord-048322-5eqdrd52	16	6	introduced	introduce	VBN
cord-048322-5eqdrd52	16	7	for	for	IN
cord-048322-5eqdrd52	16	8	the	the	DT
cord-048322-5eqdrd52	16	9	specific	specific	JJ
cord-048322-5eqdrd52	16	10	inhibition	inhibition	NN
cord-048322-5eqdrd52	16	11	of	of	IN
cord-048322-5eqdrd52	16	12	gene	gene	NN
cord-048322-5eqdrd52	16	13	expression	expression	NN
cord-048322-5eqdrd52	16	14	was	be	VBD
cord-048322-5eqdrd52	16	15	the	the	DT
cord-048322-5eqdrd52	16	16	use	use	NN
cord-048322-5eqdrd52	16	17	of	of	IN
cord-048322-5eqdrd52	16	18	antisense	antisense	NN
cord-048322-5eqdrd52	16	19	oligonucleotides	oligonucleotide	NNS
cord-048322-5eqdrd52	16	20	in	in	IN
cord-048322-5eqdrd52	16	21	the	the	DT
cord-048322-5eqdrd52	16	22	late	late	JJ
cord-048322-5eqdrd52	16	23	1970s	1970	NNS
cord-048322-5eqdrd52	16	24	[	[	-LRB-
cord-048322-5eqdrd52	16	25	1	1	CD
cord-048322-5eqdrd52	16	26	,	,	,
cord-048322-5eqdrd52	16	27	2	2	CD
cord-048322-5eqdrd52	16	28	]	]	-RRB-
cord-048322-5eqdrd52	16	29	.	.	.
cord-048322-5eqdrd52	17	1	Upon	upon	IN
cord-048322-5eqdrd52	17	2	their	-PRON-	PRP$
cord-048322-5eqdrd52	17	3	introduction	introduction	NN
cord-048322-5eqdrd52	17	4	into	into	IN
cord-048322-5eqdrd52	17	5	a	a	DT
cord-048322-5eqdrd52	17	6	cell	cell	NN
cord-048322-5eqdrd52	17	7	,	,	,
cord-048322-5eqdrd52	17	8	antisense	antisense	NN
cord-048322-5eqdrd52	17	9	ODNs	ODNs	NNP
cord-048322-5eqdrd52	17	10	are	be	VBP
cord-048322-5eqdrd52	17	11	able	able	JJ
cord-048322-5eqdrd52	17	12	to	to	TO
cord-048322-5eqdrd52	17	13	hybridize	hybridize	VB
cord-048322-5eqdrd52	17	14	to	to	IN
cord-048322-5eqdrd52	17	15	their	-PRON-	PRP$
cord-048322-5eqdrd52	17	16	target	target	NN
cord-048322-5eqdrd52	17	17	RNA	RNA	NNP
cord-048322-5eqdrd52	17	18	leading	lead	VBG
cord-048322-5eqdrd52	17	19	to	to	IN
cord-048322-5eqdrd52	17	20	the	the	DT
cord-048322-5eqdrd52	17	21	degradation	degradation	NN
cord-048322-5eqdrd52	17	22	of	of	IN
cord-048322-5eqdrd52	17	23	the	the	DT
cord-048322-5eqdrd52	17	24	RNA	RNA	NNP
cord-048322-5eqdrd52	17	25	-	-	HYPH
cord-048322-5eqdrd52	17	26	DNA	dna	NN
cord-048322-5eqdrd52	17	27	hybrid	hybrid	NN
cord-048322-5eqdrd52	17	28	double	double	JJ
cord-048322-5eqdrd52	17	29	strands	strand	NNS
cord-048322-5eqdrd52	17	30	through	through	IN
cord-048322-5eqdrd52	17	31	RNAase	RNAase	NNP
cord-048322-5eqdrd52	17	32	H	H	NNP
cord-048322-5eqdrd52	17	33	,	,	,
cord-048322-5eqdrd52	17	34	to	to	IN
cord-048322-5eqdrd52	17	35	the	the	DT
cord-048322-5eqdrd52	17	36	inhibition	inhibition	NN
cord-048322-5eqdrd52	17	37	of	of	IN
cord-048322-5eqdrd52	17	38	the	the	DT
cord-048322-5eqdrd52	17	39	translation	translation	NN
cord-048322-5eqdrd52	17	40	of	of	IN
cord-048322-5eqdrd52	17	41	the	the	DT
cord-048322-5eqdrd52	17	42	target	target	NN
cord-048322-5eqdrd52	17	43	mRNA	mrna	NN
cord-048322-5eqdrd52	17	44	due	due	IN
cord-048322-5eqdrd52	17	45	to	to	IN
cord-048322-5eqdrd52	17	46	a	a	DT
cord-048322-5eqdrd52	17	47	steric	steric	JJ
cord-048322-5eqdrd52	17	48	or	or	CC
cord-048322-5eqdrd52	17	49	conformational	conformational	JJ
cord-048322-5eqdrd52	17	50	obstacle	obstacle	NN
cord-048322-5eqdrd52	17	51	for	for	IN
cord-048322-5eqdrd52	17	52	protein	protein	NN
cord-048322-5eqdrd52	17	53	translation	translation	NN
cord-048322-5eqdrd52	17	54	and/or	and/or	CC
cord-048322-5eqdrd52	17	55	to	to	IN
cord-048322-5eqdrd52	17	56	the	the	DT
cord-048322-5eqdrd52	17	57	inhibition	inhibition	NN
cord-048322-5eqdrd52	17	58	of	of	IN
cord-048322-5eqdrd52	17	59	correct	correct	JJ
cord-048322-5eqdrd52	17	60	splicing	splicing	NN
cord-048322-5eqdrd52	17	61	.	.	.
cord-048322-5eqdrd52	18	1	In	in	IN
cord-048322-5eqdrd52	18	2	the	the	DT
cord-048322-5eqdrd52	18	3	early	early	JJ
cord-048322-5eqdrd52	18	4	1980s	1980	NNS
cord-048322-5eqdrd52	18	5	,	,	,
cord-048322-5eqdrd52	18	6	the	the	DT
cord-048322-5eqdrd52	18	7	discovery	discovery	NN
cord-048322-5eqdrd52	18	8	of	of	IN
cord-048322-5eqdrd52	18	9	ribozymes	ribozyme	NNS
cord-048322-5eqdrd52	18	10	,	,	,
cord-048322-5eqdrd52	18	11	that	that	RB
cord-048322-5eqdrd52	18	12	is	is	RB
cord-048322-5eqdrd52	18	13	,	,	,
cord-048322-5eqdrd52	18	14	catalytically	catalytically	RB
cord-048322-5eqdrd52	18	15	active	active	JJ
cord-048322-5eqdrd52	18	16	RNAs	rna	NNS
cord-048322-5eqdrd52	18	17	which	which	WDT
cord-048322-5eqdrd52	18	18	are	be	VBP
cord-048322-5eqdrd52	18	19	able	able	JJ
cord-048322-5eqdrd52	18	20	to	to	TO
cord-048322-5eqdrd52	18	21	sequence	sequence	VB
cord-048322-5eqdrd52	18	22	-	-	:
cord-048322-5eqdrd52	18	23	specifically	specifically	RB
cord-048322-5eqdrd52	18	24	cleave	cleave	VB
cord-048322-5eqdrd52	18	25	a	a	DT
cord-048322-5eqdrd52	18	26	target	target	NN
cord-048322-5eqdrd52	18	27	mRNA	mrna	NN
cord-048322-5eqdrd52	18	28	,	,	,
cord-048322-5eqdrd52	18	29	further	further	RB
cord-048322-5eqdrd52	18	30	expanded	expand	VBN
cord-048322-5eqdrd52	18	31	gene	gene	NN
cord-048322-5eqdrd52	18	32	-	-	HYPH
cord-048322-5eqdrd52	18	33	targeting	target	VBG
cord-048322-5eqdrd52	18	34	strategies	strategy	NNS
cord-048322-5eqdrd52	18	35	[	[	-LRB-
cord-048322-5eqdrd52	18	36	3	3	CD
cord-048322-5eqdrd52	18	37	]	]	-RRB-
cord-048322-5eqdrd52	18	38	[	[	-LRB-
cord-048322-5eqdrd52	18	39	4	4	CD
cord-048322-5eqdrd52	18	40	]	]	-RRB-
cord-048322-5eqdrd52	18	41	[	[	-LRB-
cord-048322-5eqdrd52	18	42	5	5	CD
cord-048322-5eqdrd52	18	43	]	]	-RRB-
cord-048322-5eqdrd52	18	44	.	.	.
cord-048322-5eqdrd52	19	1	Subsequently	subsequently	RB
cord-048322-5eqdrd52	19	2	,	,	,
cord-048322-5eqdrd52	19	3	both	both	DT
cord-048322-5eqdrd52	19	4	methods	method	NNS
cord-048322-5eqdrd52	19	5	were	be	VBD
cord-048322-5eqdrd52	19	6	extensively	extensively	RB
cord-048322-5eqdrd52	19	7	studied	study	VBN
cord-048322-5eqdrd52	19	8	and	and	CC
cord-048322-5eqdrd52	19	9	further	further	RB
cord-048322-5eqdrd52	19	10	developed	develop	VBN
cord-048322-5eqdrd52	19	11	with	with	IN
cord-048322-5eqdrd52	19	12	regard	regard	NN
cord-048322-5eqdrd52	19	13	to	to	IN
cord-048322-5eqdrd52	19	14	the	the	DT
cord-048322-5eqdrd52	19	15	optimization	optimization	NN
cord-048322-5eqdrd52	19	16	of	of	IN
cord-048322-5eqdrd52	19	17	targeting	target	VBG
cord-048322-5eqdrd52	19	18	efficacies	efficacy	NNS
cord-048322-5eqdrd52	19	19	and	and	CC
cord-048322-5eqdrd52	19	20	antisense	antisense	NN
cord-048322-5eqdrd52	19	21	-	-	HYPH
cord-048322-5eqdrd52	19	22	ODN	ODN	NNP
cord-048322-5eqdrd52	19	23	/	/	SYM
cord-048322-5eqdrd52	19	24	ribozyme	ribozyme	NN
cord-048322-5eqdrd52	19	25	delivery	delivery	NN
cord-048322-5eqdrd52	19	26	strategies	strategy	NNS
cord-048322-5eqdrd52	19	27	in	in	IN
cord-048322-5eqdrd52	19	28	vitro	vitro	FW
cord-048322-5eqdrd52	19	29	and	and	CC
cord-048322-5eqdrd52	19	30	in	in	IN
cord-048322-5eqdrd52	19	31	vivo	vivo	NNP
cord-048322-5eqdrd52	19	32	.	.	.
cord-048322-5eqdrd52	20	1	Most	most	RBS
cord-048322-5eqdrd52	20	2	recently	recently	RB
cord-048322-5eqdrd52	20	3	,	,	,
cord-048322-5eqdrd52	20	4	another	another	DT
cord-048322-5eqdrd52	20	5	naturally	naturally	RB
cord-048322-5eqdrd52	20	6	occurring	occur	VBG
cord-048322-5eqdrd52	20	7	biological	biological	JJ
cord-048322-5eqdrd52	20	8	strategy	strategy	NN
cord-048322-5eqdrd52	20	9	for	for	IN
cord-048322-5eqdrd52	20	10	gene	gene	NN
cord-048322-5eqdrd52	20	11	silencing	silencing	NN
cord-048322-5eqdrd52	20	12	has	have	VBZ
cord-048322-5eqdrd52	20	13	been	be	VBN
cord-048322-5eqdrd52	20	14	discovered	discover	VBN
cord-048322-5eqdrd52	20	15	and	and	CC
cord-048322-5eqdrd52	20	16	termed	term	VBN
cord-048322-5eqdrd52	20	17	RNA	RNA	NNP
cord-048322-5eqdrd52	20	18	interference	interference	NN
cord-048322-5eqdrd52	20	19	(	(	-LRB-
cord-048322-5eqdrd52	20	20	RNAi	RNAi	NNP
cord-048322-5eqdrd52	20	21	)	)	-RRB-
cord-048322-5eqdrd52	20	22	.	.	.
cord-048322-5eqdrd52	21	1	Since	since	IN
cord-048322-5eqdrd52	21	2	RNAi	RNAi	NNP
cord-048322-5eqdrd52	21	3	represents	represent	VBZ
cord-048322-5eqdrd52	21	4	a	a	DT
cord-048322-5eqdrd52	21	5	particularly	particularly	RB
cord-048322-5eqdrd52	21	6	powerful	powerful	JJ
cord-048322-5eqdrd52	21	7	method	method	NN
cord-048322-5eqdrd52	21	8	for	for	IN
cord-048322-5eqdrd52	21	9	specific	specific	JJ
cord-048322-5eqdrd52	21	10	gene	gene	NN
cord-048322-5eqdrd52	21	11	silencing	silencing	NN
cord-048322-5eqdrd52	21	12	and	and	CC
cord-048322-5eqdrd52	21	13	is	be	VBZ
cord-048322-5eqdrd52	21	14	able	able	JJ
cord-048322-5eqdrd52	21	15	to	to	TO
cord-048322-5eqdrd52	21	16	provide	provide	VB
cord-048322-5eqdrd52	21	17	the	the	DT
cord-048322-5eqdrd52	21	18	relatively	relatively	RB
cord-048322-5eqdrd52	21	19	easy	easy	JJ
cord-048322-5eqdrd52	21	20	ablation	ablation	NN
cord-048322-5eqdrd52	21	21	of	of	IN
cord-048322-5eqdrd52	21	22	the	the	DT
cord-048322-5eqdrd52	21	23	expression	expression	NN
cord-048322-5eqdrd52	21	24	of	of	IN
cord-048322-5eqdrd52	21	25	any	any	DT
cord-048322-5eqdrd52	21	26	given	give	VBN
cord-048322-5eqdrd52	21	27	target	target	NN
cord-048322-5eqdrd52	21	28	gene	gene	NN
cord-048322-5eqdrd52	21	29	,	,	,
cord-048322-5eqdrd52	21	30	it	-PRON-	PRP
cord-048322-5eqdrd52	21	31	is	be	VBZ
cord-048322-5eqdrd52	21	32	now	now	RB
cord-048322-5eqdrd52	21	33	commonly	commonly	RB
cord-048322-5eqdrd52	21	34	used	use	VBN
cord-048322-5eqdrd52	21	35	as	as	IN
cord-048322-5eqdrd52	21	36	a	a	DT
cord-048322-5eqdrd52	21	37	tool	tool	NN
cord-048322-5eqdrd52	21	38	in	in	IN
cord-048322-5eqdrd52	21	39	biological	biological	JJ
cord-048322-5eqdrd52	21	40	and	and	CC
cord-048322-5eqdrd52	21	41	biomedical	biomedical	JJ
cord-048322-5eqdrd52	21	42	research	research	NN
cord-048322-5eqdrd52	21	43	.	.	.
cord-048322-5eqdrd52	22	1	This	this	DT
cord-048322-5eqdrd52	22	2	includes	include	VBZ
cord-048322-5eqdrd52	22	3	the	the	DT
cord-048322-5eqdrd52	22	4	RNAimediated	rnaimediate	VBN
cord-048322-5eqdrd52	22	5	targeting	targeting	NN
cord-048322-5eqdrd52	22	6	in	in	IN
cord-048322-5eqdrd52	22	7	vitro	vitro	FW
cord-048322-5eqdrd52	22	8	and	and	CC
cord-048322-5eqdrd52	22	9	in	in	IN
cord-048322-5eqdrd52	22	10	vivo	vivo	NN
cord-048322-5eqdrd52	22	11	for	for	IN
cord-048322-5eqdrd52	22	12	functional	functional	JJ
cord-048322-5eqdrd52	22	13	studies	study	NNS
cord-048322-5eqdrd52	22	14	of	of	IN
cord-048322-5eqdrd52	22	15	various	various	JJ
cord-048322-5eqdrd52	22	16	genes	gene	NNS
cord-048322-5eqdrd52	22	17	whose	whose	WP$
cord-048322-5eqdrd52	22	18	expression	expression	NN
cord-048322-5eqdrd52	22	19	is	be	VBZ
cord-048322-5eqdrd52	22	20	known	know	VBN
cord-048322-5eqdrd52	22	21	to	to	TO
cord-048322-5eqdrd52	22	22	be	be	VB
cord-048322-5eqdrd52	22	23	upregulated	upregulate	VBN
cord-048322-5eqdrd52	22	24	as	as	RB
cord-048322-5eqdrd52	22	25	well	well	RB
cord-048322-5eqdrd52	22	26	as	as	IN
cord-048322-5eqdrd52	22	27	the	the	DT
cord-048322-5eqdrd52	22	28	development	development	NN
cord-048322-5eqdrd52	22	29	of	of	IN
cord-048322-5eqdrd52	22	30	novel	novel	JJ
cord-048322-5eqdrd52	22	31	therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	22	32	approaches	approach	NNS
cord-048322-5eqdrd52	22	33	based	base	VBN
cord-048322-5eqdrd52	22	34	on	on	IN
cord-048322-5eqdrd52	22	35	gene	gene	NN
cord-048322-5eqdrd52	22	36	targeting	targeting	NN
cord-048322-5eqdrd52	22	37	.	.	.
cord-048322-5eqdrd52	23	1	double	double	RB
cord-048322-5eqdrd52	23	2	-	-	HYPH
cord-048322-5eqdrd52	23	3	stranded	strand	VBN
cord-048322-5eqdrd52	23	4	RNA	RNA	NNP
cord-048322-5eqdrd52	23	5	molecules	molecule	NNS
cord-048322-5eqdrd52	23	6	as	as	IN
cord-048322-5eqdrd52	23	7	described	describe	VBN
cord-048322-5eqdrd52	23	8	first	first	RB
cord-048322-5eqdrd52	23	9	in	in	IN
cord-048322-5eqdrd52	23	10	C	C	NNP
cord-048322-5eqdrd52	23	11	elegans	elegan	NNS
cord-048322-5eqdrd52	23	12	by	by	IN
cord-048322-5eqdrd52	23	13	Fire	Fire	NNP
cord-048322-5eqdrd52	23	14	et	et	NNP
cord-048322-5eqdrd52	23	15	al	al	NNP
cord-048322-5eqdrd52	23	16	[	[	-LRB-
cord-048322-5eqdrd52	23	17	6	6	CD
cord-048322-5eqdrd52	23	18	]	]	-RRB-
cord-048322-5eqdrd52	23	19	who	who	WP
cord-048322-5eqdrd52	23	20	then	then	RB
cord-048322-5eqdrd52	23	21	introduced	introduce	VBD
cord-048322-5eqdrd52	23	22	the	the	DT
cord-048322-5eqdrd52	23	23	name	name	NN
cord-048322-5eqdrd52	23	24	RNA	RNA	NNP
cord-048322-5eqdrd52	23	25	interference	interference	NN
cord-048322-5eqdrd52	23	26	.	.	.
cord-048322-5eqdrd52	24	1	These	these	DT
cord-048322-5eqdrd52	24	2	findings	finding	NNS
cord-048322-5eqdrd52	24	3	also	also	RB
cord-048322-5eqdrd52	24	4	explained	explain	VBD
cord-048322-5eqdrd52	24	5	earlier	early	JJR
cord-048322-5eqdrd52	24	6	observations	observation	NNS
cord-048322-5eqdrd52	24	7	in	in	IN
cord-048322-5eqdrd52	24	8	petunias	petunia	NNS
cord-048322-5eqdrd52	24	9	which	which	WDT
cord-048322-5eqdrd52	24	10	turned	turn	VBD
cord-048322-5eqdrd52	24	11	white	white	JJ
cord-048322-5eqdrd52	24	12	rather	rather	RB
cord-048322-5eqdrd52	24	13	than	than	IN
cord-048322-5eqdrd52	24	14	purple	purple	JJ
cord-048322-5eqdrd52	24	15	upon	upon	IN
cord-048322-5eqdrd52	24	16	the	the	DT
cord-048322-5eqdrd52	24	17	introduction	introduction	NN
cord-048322-5eqdrd52	24	18	of	of	IN
cord-048322-5eqdrd52	24	19	the	the	DT
cord-048322-5eqdrd52	24	20	"	"	``
cord-048322-5eqdrd52	24	21	purple	purple	JJ
cord-048322-5eqdrd52	24	22	gene	gene	NN
cord-048322-5eqdrd52	24	23	"	"	''
cord-048322-5eqdrd52	24	24	in	in	IN
cord-048322-5eqdrd52	24	25	form	form	NN
cord-048322-5eqdrd52	24	26	of	of	IN
cord-048322-5eqdrd52	24	27	dsRNA	dsrna	NN
cord-048322-5eqdrd52	24	28	[	[	-LRB-
cord-048322-5eqdrd52	24	29	7	7	CD
cord-048322-5eqdrd52	24	30	]	]	-RRB-
cord-048322-5eqdrd52	24	31	,	,	,
cord-048322-5eqdrd52	24	32	and	and	CC
cord-048322-5eqdrd52	24	33	on	on	IN
cord-048322-5eqdrd52	24	34	gene	gene	NN
cord-048322-5eqdrd52	24	35	silencing	silencing	NN
cord-048322-5eqdrd52	24	36	by	by	IN
cord-048322-5eqdrd52	24	37	antisense	antisense	NN
cord-048322-5eqdrd52	24	38	oligonucleotides	oligonucleotide	NNS
cord-048322-5eqdrd52	24	39	as	as	RB
cord-048322-5eqdrd52	24	40	well	well	RB
cord-048322-5eqdrd52	24	41	as	as	IN
cord-048322-5eqdrd52	24	42	by	by	IN
cord-048322-5eqdrd52	24	43	sense	sense	NN
cord-048322-5eqdrd52	24	44	oligonucleotides	oligonucleotide	NNS
cord-048322-5eqdrd52	24	45	in	in	IN
cord-048322-5eqdrd52	24	46	C	c	NN
cord-048322-5eqdrd52	24	47	elegans	elegan	NNS
cord-048322-5eqdrd52	24	48	[	[	-LRB-
cord-048322-5eqdrd52	24	49	8	8	CD
cord-048322-5eqdrd52	24	50	]	]	-RRB-
cord-048322-5eqdrd52	24	51	.	.	.
cord-048322-5eqdrd52	25	1	Subsequent	subsequent	JJ
cord-048322-5eqdrd52	25	2	studies	study	NNS
cord-048322-5eqdrd52	25	3	demonstrated	demonstrate	VBD
cord-048322-5eqdrd52	25	4	that	that	IN
cord-048322-5eqdrd52	25	5	RNAi	RNAi	NNP
cord-048322-5eqdrd52	25	6	,	,	,
cord-048322-5eqdrd52	25	7	while	while	IN
cord-048322-5eqdrd52	25	8	described	describe	VBN
cord-048322-5eqdrd52	25	9	under	under	IN
cord-048322-5eqdrd52	25	10	different	different	JJ
cord-048322-5eqdrd52	25	11	names	name	NNS
cord-048322-5eqdrd52	25	12	(	(	-LRB-
cord-048322-5eqdrd52	25	13	posttranscriptional	posttranscriptional	JJ
cord-048322-5eqdrd52	25	14	gene	gene	NN
cord-048322-5eqdrd52	25	15	silencing	silencing	NN
cord-048322-5eqdrd52	25	16	(	(	-LRB-
cord-048322-5eqdrd52	25	17	PTGS	PTGS	NNP
cord-048322-5eqdrd52	25	18	)	)	-RRB-
cord-048322-5eqdrd52	25	19	,	,	,
cord-048322-5eqdrd52	25	20	cosuppression	cosuppression	NN
cord-048322-5eqdrd52	25	21	,	,	,
cord-048322-5eqdrd52	25	22	quelling	quell	VBG
cord-048322-5eqdrd52	25	23	)	)	-RRB-
cord-048322-5eqdrd52	25	24	,	,	,
cord-048322-5eqdrd52	25	25	is	be	VBZ
cord-048322-5eqdrd52	25	26	present	present	JJ
cord-048322-5eqdrd52	25	27	in	in	IN
cord-048322-5eqdrd52	25	28	most	most	JJS
cord-048322-5eqdrd52	25	29	eukaryotic	eukaryotic	JJ
cord-048322-5eqdrd52	25	30	organisms	organism	NNS
cord-048322-5eqdrd52	25	31	with	with	IN
cord-048322-5eqdrd52	25	32	the	the	DT
cord-048322-5eqdrd52	25	33	response	response	NN
cord-048322-5eqdrd52	25	34	to	to	IN
cord-048322-5eqdrd52	25	35	dsRNA	dsrna	NN
cord-048322-5eqdrd52	25	36	,	,	,
cord-048322-5eqdrd52	25	37	however	however	RB
cord-048322-5eqdrd52	25	38	,	,	,
cord-048322-5eqdrd52	25	39	being	be	VBG
cord-048322-5eqdrd52	25	40	more	more	RBR
cord-048322-5eqdrd52	25	41	complicated	complicated	JJ
cord-048322-5eqdrd52	25	42	in	in	IN
cord-048322-5eqdrd52	25	43	higher	high	JJR
cord-048322-5eqdrd52	25	44	organisms	organism	NNS
cord-048322-5eqdrd52	25	45	.	.	.
cord-048322-5eqdrd52	26	1	RNAi	RNAi	NNP
cord-048322-5eqdrd52	26	2	relies	rely	VBZ
cord-048322-5eqdrd52	26	3	on	on	IN
cord-048322-5eqdrd52	26	4	a	a	DT
cord-048322-5eqdrd52	26	5	multistep	multistep	JJ
cord-048322-5eqdrd52	26	6	intracellular	intracellular	JJ
cord-048322-5eqdrd52	26	7	pathway	pathway	NN
cord-048322-5eqdrd52	26	8	which	which	WDT
cord-048322-5eqdrd52	26	9	can	can	MD
cord-048322-5eqdrd52	26	10	be	be	VB
cord-048322-5eqdrd52	26	11	roughly	roughly	RB
cord-048322-5eqdrd52	26	12	divided	divide	VBN
cord-048322-5eqdrd52	26	13	into	into	IN
cord-048322-5eqdrd52	26	14	two	two	CD
cord-048322-5eqdrd52	26	15	phases	phase	NNS
cord-048322-5eqdrd52	26	16	,	,	,
cord-048322-5eqdrd52	26	17	that	that	RB
cord-048322-5eqdrd52	26	18	is	is	RB
cord-048322-5eqdrd52	26	19	,	,	,
cord-048322-5eqdrd52	26	20	the	the	DT
cord-048322-5eqdrd52	26	21	initiation	initiation	NN
cord-048322-5eqdrd52	26	22	phase	phase	NN
cord-048322-5eqdrd52	26	23	and	and	CC
cord-048322-5eqdrd52	26	24	the	the	DT
cord-048322-5eqdrd52	26	25	effector	effector	NN
cord-048322-5eqdrd52	26	26	phase	phase	NN
cord-048322-5eqdrd52	26	27	.	.	.
cord-048322-5eqdrd52	27	1	In	in	IN
cord-048322-5eqdrd52	27	2	the	the	DT
cord-048322-5eqdrd52	27	3	initiation	initiation	NN
cord-048322-5eqdrd52	27	4	phase	phase	NN
cord-048322-5eqdrd52	27	5	,	,	,
cord-048322-5eqdrd52	27	6	double	double	RB
cord-048322-5eqdrd52	27	7	-	-	HYPH
cord-048322-5eqdrd52	27	8	stranded	strand	VBN
cord-048322-5eqdrd52	27	9	RNA	RNA	NNP
cord-048322-5eqdrd52	27	10	molecules	molecule	NNS
cord-048322-5eqdrd52	27	11	from	from	IN
cord-048322-5eqdrd52	27	12	endogenous	endogenous	JJ
cord-048322-5eqdrd52	27	13	or	or	CC
cord-048322-5eqdrd52	27	14	exogenous	exogenous	JJ
cord-048322-5eqdrd52	27	15	origin	origin	NN
cord-048322-5eqdrd52	27	16	present	present	JJ
cord-048322-5eqdrd52	27	17	in	in	IN
cord-048322-5eqdrd52	27	18	the	the	DT
cord-048322-5eqdrd52	27	19	cell	cell	NN
cord-048322-5eqdrd52	27	20	are	be	VBP
cord-048322-5eqdrd52	27	21	processed	process	VBN
cord-048322-5eqdrd52	27	22	through	through	IN
cord-048322-5eqdrd52	27	23	the	the	DT
cord-048322-5eqdrd52	27	24	cleavage	cleavage	NN
cord-048322-5eqdrd52	27	25	activity	activity	NN
cord-048322-5eqdrd52	27	26	of	of	IN
cord-048322-5eqdrd52	27	27	a	a	DT
cord-048322-5eqdrd52	27	28	ribonuclease	ribonuclease	NN
cord-048322-5eqdrd52	27	29	III	iii	CD
cord-048322-5eqdrd52	27	30	-	-	HYPH
cord-048322-5eqdrd52	27	31	type	type	NN
cord-048322-5eqdrd52	27	32	protein	protein	NN
cord-048322-5eqdrd52	27	33	[	[	-LRB-
cord-048322-5eqdrd52	27	34	9	9	CD
cord-048322-5eqdrd52	27	35	]	]	-RRB-
cord-048322-5eqdrd52	27	36	[	[	-LRB-
cord-048322-5eqdrd52	27	37	10	10	CD
cord-048322-5eqdrd52	27	38	]	]	-RRB-
cord-048322-5eqdrd52	27	39	[	[	-LRB-
cord-048322-5eqdrd52	27	40	11	11	CD
cord-048322-5eqdrd52	27	41	]	]	-RRB-
cord-048322-5eqdrd52	27	42	[	[	-LRB-
cord-048322-5eqdrd52	27	43	12	12	CD
cord-048322-5eqdrd52	27	44	]	]	-RRB-
cord-048322-5eqdrd52	27	45	into	into	IN
cord-048322-5eqdrd52	27	46	short	short	JJ
cord-048322-5eqdrd52	27	47	21	21	CD
cord-048322-5eqdrd52	27	48	-	-	SYM
cord-048322-5eqdrd52	27	49	23	23	CD
cord-048322-5eqdrd52	27	50	nucleotide	nucleotide	JJ
cord-048322-5eqdrd52	27	51	fragments	fragment	NNS
cord-048322-5eqdrd52	27	52	termed	term	VBD
cord-048322-5eqdrd52	27	53	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	27	54	.	.	.
cord-048322-5eqdrd52	28	1	These	these	DT
cord-048322-5eqdrd52	28	2	effector	effector	VBP
cord-048322-5eqdrd52	28	3	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	28	4	,	,	,
cord-048322-5eqdrd52	28	5	which	which	WDT
cord-048322-5eqdrd52	28	6	contain	contain	VBP
cord-048322-5eqdrd52	28	7	a	a	DT
cord-048322-5eqdrd52	28	8	symmetric	symmetric	JJ
cord-048322-5eqdrd52	28	9	2	2	CD
cord-048322-5eqdrd52	28	10	nt	nt	NN
cord-048322-5eqdrd52	28	11	overhang	overhang	NN
cord-048322-5eqdrd52	28	12	at	at	IN
cord-048322-5eqdrd52	28	13	the	the	DT
cord-048322-5eqdrd52	28	14	3	3	CD
cord-048322-5eqdrd52	28	15	-end	-end	:
cord-048322-5eqdrd52	28	16	as	as	RB
cord-048322-5eqdrd52	28	17	well	well	RB
cord-048322-5eqdrd52	28	18	as	as	IN
cord-048322-5eqdrd52	28	19	a	a	DT
cord-048322-5eqdrd52	28	20	5	5	CD
cord-048322-5eqdrd52	28	21	-phosphate	-phosphate	NN
cord-048322-5eqdrd52	28	22	and	and	CC
cord-048322-5eqdrd52	28	23	a	a	DT
cord-048322-5eqdrd52	28	24	3hydroxy	3hydroxy	CD
cord-048322-5eqdrd52	28	25	group	group	NN
cord-048322-5eqdrd52	28	26	,	,	,
cord-048322-5eqdrd52	28	27	are	be	VBP
cord-048322-5eqdrd52	28	28	then	then	RB
cord-048322-5eqdrd52	28	29	in	in	IN
cord-048322-5eqdrd52	28	30	the	the	DT
cord-048322-5eqdrd52	28	31	effector	effector	NN
cord-048322-5eqdrd52	28	32	phase	phase	NN
cord-048322-5eqdrd52	28	33	incorporated	incorporate	VBN
cord-048322-5eqdrd52	28	34	into	into	IN
cord-048322-5eqdrd52	28	35	a	a	DT
cord-048322-5eqdrd52	28	36	nuclease	nuclease	NN
cord-048322-5eqdrd52	28	37	-	-	HYPH
cord-048322-5eqdrd52	28	38	containing	contain	VBG
cord-048322-5eqdrd52	28	39	multiprotein	multiprotein	NNP
cord-048322-5eqdrd52	28	40	complex	complex	NN
cord-048322-5eqdrd52	28	41	called	call	VBN
cord-048322-5eqdrd52	28	42	RISC	RISC	NNP
cord-048322-5eqdrd52	28	43	(	(	-LRB-
cord-048322-5eqdrd52	28	44	RNA	RNA	NNP
cord-048322-5eqdrd52	28	45	-	-	HYPH
cord-048322-5eqdrd52	28	46	induced	induce	VBN
cord-048322-5eqdrd52	28	47	silencing	silence	VBG
cord-048322-5eqdrd52	28	48	complex	complex	NN
cord-048322-5eqdrd52	28	49	)	)	-RRB-
cord-048322-5eqdrd52	28	50	[	[	-LRB-
cord-048322-5eqdrd52	28	51	13	13	CD
cord-048322-5eqdrd52	28	52	]	]	-RRB-
cord-048322-5eqdrd52	28	53	.	.	.
cord-048322-5eqdrd52	29	1	Several	several	JJ
cord-048322-5eqdrd52	29	2	structural	structural	JJ
cord-048322-5eqdrd52	29	3	and	and	CC
cord-048322-5eqdrd52	29	4	biochemical	biochemical	JJ
cord-048322-5eqdrd52	29	5	studies	study	NNS
cord-048322-5eqdrd52	29	6	have	have	VBP
cord-048322-5eqdrd52	29	7	shed	shed	VBN
cord-048322-5eqdrd52	29	8	light	light	NN
cord-048322-5eqdrd52	29	9	on	on	IN
cord-048322-5eqdrd52	29	10	the	the	DT
cord-048322-5eqdrd52	29	11	processing	processing	NN
cord-048322-5eqdrd52	29	12	of	of	IN
cord-048322-5eqdrd52	29	13	double	double	RB
cord-048322-5eqdrd52	29	14	-	-	HYPH
cord-048322-5eqdrd52	29	15	stranded	strand	VBN
cord-048322-5eqdrd52	29	16	RNA	RNA	NNP
cord-048322-5eqdrd52	29	17	and	and	CC
cord-048322-5eqdrd52	29	18	the	the	DT
cord-048322-5eqdrd52	29	19	formation	formation	NN
cord-048322-5eqdrd52	29	20	of	of	IN
cord-048322-5eqdrd52	29	21	the	the	DT
cord-048322-5eqdrd52	29	22	RISC	RISC	NNP
cord-048322-5eqdrd52	29	23	complex	complex	NN
cord-048322-5eqdrd52	29	24	(	(	-LRB-
cord-048322-5eqdrd52	29	25	see	see	VB
cord-048322-5eqdrd52	29	26	,	,	,
cord-048322-5eqdrd52	29	27	eg	eg	XX
cord-048322-5eqdrd52	29	28	,	,	,
cord-048322-5eqdrd52	29	29	[	[	-LRB-
cord-048322-5eqdrd52	29	30	14	14	CD
cord-048322-5eqdrd52	29	31	]	]	-RRB-
cord-048322-5eqdrd52	29	32	for	for	IN
cord-048322-5eqdrd52	29	33	a	a	DT
cord-048322-5eqdrd52	29	34	recent	recent	JJ
cord-048322-5eqdrd52	29	35	review	review	NN
cord-048322-5eqdrd52	29	36	)	)	-RRB-
cord-048322-5eqdrd52	29	37	.	.	.
cord-048322-5eqdrd52	30	1	Through	through	IN
cord-048322-5eqdrd52	30	2	unwinding	unwind	VBG
cord-048322-5eqdrd52	30	3	of	of	IN
cord-048322-5eqdrd52	30	4	the	the	DT
cord-048322-5eqdrd52	30	5	siRNA	siRNA	NNP
cord-048322-5eqdrd52	30	6	duplex	duplex	NNP
cord-048322-5eqdrd52	30	7	by	by	IN
cord-048322-5eqdrd52	30	8	an	an	DT
cord-048322-5eqdrd52	30	9	RNA	RNA	NNP
cord-048322-5eqdrd52	30	10	helicase	helicase	NN
cord-048322-5eqdrd52	30	11	activity	activity	NN
cord-048322-5eqdrd52	30	12	[	[	-LRB-
cord-048322-5eqdrd52	30	13	15	15	CD
cord-048322-5eqdrd52	30	14	]	]	-RRB-
cord-048322-5eqdrd52	30	15	,	,	,
cord-048322-5eqdrd52	30	16	this	this	DT
cord-048322-5eqdrd52	30	17	complex	complex	NN
cord-048322-5eqdrd52	30	18	becomes	become	VBZ
cord-048322-5eqdrd52	30	19	activated	activate	VBN
cord-048322-5eqdrd52	30	20	with	with	IN
cord-048322-5eqdrd52	30	21	the	the	DT
cord-048322-5eqdrd52	30	22	single	single	RB
cord-048322-5eqdrd52	30	23	-	-	HYPH
cord-048322-5eqdrd52	30	24	stranded	stranded	JJ
cord-048322-5eqdrd52	30	25	siRNA	sirna	NN
cord-048322-5eqdrd52	30	26	guiding	guide	VBG
cord-048322-5eqdrd52	30	27	the	the	DT
cord-048322-5eqdrd52	30	28	RISC	RISC	NNP
cord-048322-5eqdrd52	30	29	complex	complex	NN
cord-048322-5eqdrd52	30	30	to	to	IN
cord-048322-5eqdrd52	30	31	its	-PRON-	PRP$
cord-048322-5eqdrd52	30	32	complementary	complementary	JJ
cord-048322-5eqdrd52	30	33	target	target	NN
cord-048322-5eqdrd52	30	34	RNA	RNA	NNP
cord-048322-5eqdrd52	30	35	.	.	.
cord-048322-5eqdrd52	31	1	Upon	upon	IN
cord-048322-5eqdrd52	31	2	the	the	DT
cord-048322-5eqdrd52	31	3	binding	binding	NN
cord-048322-5eqdrd52	31	4	of	of	IN
cord-048322-5eqdrd52	31	5	the	the	DT
cord-048322-5eqdrd52	31	6	siRNA	siRNA	NNP
cord-048322-5eqdrd52	31	7	through	through	IN
cord-048322-5eqdrd52	31	8	hybridization	hybridization	NN
cord-048322-5eqdrd52	31	9	to	to	IN
cord-048322-5eqdrd52	31	10	its	-PRON-	PRP$
cord-048322-5eqdrd52	31	11	target	target	NN
cord-048322-5eqdrd52	31	12	mRNA	mrna	NN
cord-048322-5eqdrd52	31	13	,	,	,
cord-048322-5eqdrd52	31	14	the	the	DT
cord-048322-5eqdrd52	31	15	RISC	RISC	NNP
cord-048322-5eqdrd52	31	16	complex	complex	NN
cord-048322-5eqdrd52	31	17	catalyses	catalyse	VBZ
cord-048322-5eqdrd52	31	18	the	the	DT
cord-048322-5eqdrd52	31	19	endonucleolytical	endonucleolytical	JJ
cord-048322-5eqdrd52	31	20	cleavage	cleavage	NN
cord-048322-5eqdrd52	31	21	of	of	IN
cord-048322-5eqdrd52	31	22	the	the	DT
cord-048322-5eqdrd52	31	23	mRNA	mRNA	NNP
cord-048322-5eqdrd52	31	24	strand	strand	NN
cord-048322-5eqdrd52	31	25	within	within	IN
cord-048322-5eqdrd52	31	26	the	the	DT
cord-048322-5eqdrd52	31	27	target	target	NN
cord-048322-5eqdrd52	31	28	site	site	NN
cord-048322-5eqdrd52	31	29	,	,	,
cord-048322-5eqdrd52	31	30	which	which	WDT
cord-048322-5eqdrd52	31	31	,	,	,
cord-048322-5eqdrd52	31	32	due	due	IN
cord-048322-5eqdrd52	31	33	to	to	IN
cord-048322-5eqdrd52	31	34	the	the	DT
cord-048322-5eqdrd52	31	35	generation	generation	NN
cord-048322-5eqdrd52	31	36	of	of	IN
cord-048322-5eqdrd52	31	37	unprotected	unprotected	JJ
cord-048322-5eqdrd52	31	38	RNA	RNA	NNP
cord-048322-5eqdrd52	31	39	ends	end	NNS
cord-048322-5eqdrd52	31	40	,	,	,
cord-048322-5eqdrd52	31	41	results	result	VBZ
cord-048322-5eqdrd52	31	42	in	in	IN
cord-048322-5eqdrd52	31	43	the	the	DT
cord-048322-5eqdrd52	31	44	rapid	rapid	JJ
cord-048322-5eqdrd52	31	45	degradation	degradation	NN
cord-048322-5eqdrd52	31	46	of	of	IN
cord-048322-5eqdrd52	31	47	the	the	DT
cord-048322-5eqdrd52	31	48	mRNA	mRNA	NNP
cord-048322-5eqdrd52	31	49	molecule	molecule	NN
cord-048322-5eqdrd52	31	50	.	.	.
cord-048322-5eqdrd52	32	1	With	with	IN
cord-048322-5eqdrd52	32	2	the	the	DT
cord-048322-5eqdrd52	32	3	RISC	RISC	NNP
cord-048322-5eqdrd52	32	4	complex	complex	NN
cord-048322-5eqdrd52	32	5	being	be	VBG
cord-048322-5eqdrd52	32	6	recovered	recover	VBN
cord-048322-5eqdrd52	32	7	for	for	IN
cord-048322-5eqdrd52	32	8	further	further	JJ
cord-048322-5eqdrd52	32	9	binding	binding	NN
cord-048322-5eqdrd52	32	10	and	and	CC
cord-048322-5eqdrd52	32	11	cleavage	cleavage	NN
cord-048322-5eqdrd52	32	12	cycles	cycle	NNS
cord-048322-5eqdrd52	32	13	,	,	,
cord-048322-5eqdrd52	32	14	the	the	DT
cord-048322-5eqdrd52	32	15	whole	whole	JJ
cord-048322-5eqdrd52	32	16	process	process	NN
cord-048322-5eqdrd52	32	17	translates	translate	VBZ
cord-048322-5eqdrd52	32	18	into	into	IN
cord-048322-5eqdrd52	32	19	a	a	DT
cord-048322-5eqdrd52	32	20	net	net	JJ
cord-048322-5eqdrd52	32	21	reduction	reduction	NN
cord-048322-5eqdrd52	32	22	of	of	IN
cord-048322-5eqdrd52	32	23	the	the	DT
cord-048322-5eqdrd52	32	24	specific	specific	JJ
cord-048322-5eqdrd52	32	25	mRNA	mRNA	NNP
cord-048322-5eqdrd52	32	26	levels	level	NNS
cord-048322-5eqdrd52	32	27	and	and	CC
cord-048322-5eqdrd52	32	28	hence	hence	RB
cord-048322-5eqdrd52	32	29	into	into	IN
cord-048322-5eqdrd52	32	30	the	the	DT
cord-048322-5eqdrd52	32	31	decreased	decreased	JJ
cord-048322-5eqdrd52	32	32	expression	expression	NN
cord-048322-5eqdrd52	32	33	of	of	IN
cord-048322-5eqdrd52	32	34	the	the	DT
cord-048322-5eqdrd52	32	35	corresponding	corresponding	JJ
cord-048322-5eqdrd52	32	36	gene	gene	NN
cord-048322-5eqdrd52	32	37	.	.	.
cord-048322-5eqdrd52	33	1	For	for	IN
cord-048322-5eqdrd52	33	2	an	an	DT
cord-048322-5eqdrd52	33	3	overview	overview	NN
cord-048322-5eqdrd52	33	4	of	of	IN
cord-048322-5eqdrd52	33	5	the	the	DT
cord-048322-5eqdrd52	33	6	RNAi	RNAi	NNP
cord-048322-5eqdrd52	33	7	pathway	pathway	NN
cord-048322-5eqdrd52	33	8	,	,	,
cord-048322-5eqdrd52	33	9	see	see	VB
cord-048322-5eqdrd52	33	10	Figure	figure	NN
cord-048322-5eqdrd52	33	11	1	1	CD
cord-048322-5eqdrd52	33	12	.	.	.
cord-048322-5eqdrd52	34	1	While	while	IN
cord-048322-5eqdrd52	34	2	from	from	IN
cord-048322-5eqdrd52	34	3	this	this	DT
cord-048322-5eqdrd52	34	4	mechanism	mechanism	NN
cord-048322-5eqdrd52	34	5	it	-PRON-	PRP
cord-048322-5eqdrd52	34	6	becomes	become	VBZ
cord-048322-5eqdrd52	34	7	obvious	obvious	JJ
cord-048322-5eqdrd52	34	8	that	that	IN
cord-048322-5eqdrd52	34	9	siRNA	siRNA	NNP
cord-048322-5eqdrd52	34	10	molecules	molecule	NNS
cord-048322-5eqdrd52	34	11	complementary	complementary	JJ
cord-048322-5eqdrd52	34	12	to	to	IN
cord-048322-5eqdrd52	34	13	the	the	DT
cord-048322-5eqdrd52	34	14	target	target	NN
cord-048322-5eqdrd52	34	15	mRNA	mrna	NN
cord-048322-5eqdrd52	34	16	and	and	CC
cord-048322-5eqdrd52	34	17	thus	thus	RB
cord-048322-5eqdrd52	34	18	being	be	VBG
cord-048322-5eqdrd52	34	19	able	able	JJ
cord-048322-5eqdrd52	34	20	to	to	TO
cord-048322-5eqdrd52	34	21	serve	serve	VB
cord-048322-5eqdrd52	34	22	as	as	IN
cord-048322-5eqdrd52	34	23	a	a	DT
cord-048322-5eqdrd52	34	24	guide	guide	NN
cord-048322-5eqdrd52	34	25	sequence	sequence	NN
cord-048322-5eqdrd52	34	26	for	for	IN
cord-048322-5eqdrd52	34	27	the	the	DT
cord-048322-5eqdrd52	34	28	RISC	RISC	NNP
cord-048322-5eqdrd52	34	29	complex	complex	NN
cord-048322-5eqdrd52	34	30	play	play	VBP
cord-048322-5eqdrd52	34	31	a	a	DT
cord-048322-5eqdrd52	34	32	pivotal	pivotal	JJ
cord-048322-5eqdrd52	34	33	role	role	NN
cord-048322-5eqdrd52	34	34	in	in	IN
cord-048322-5eqdrd52	34	35	this	this	DT
cord-048322-5eqdrd52	34	36	process	process	NN
cord-048322-5eqdrd52	34	37	,	,	,
cord-048322-5eqdrd52	34	38	they	-PRON-	PRP
cord-048322-5eqdrd52	34	39	need	nee	MD
cord-048322-5eqdrd52	34	40	not	not	RB
cord-048322-5eqdrd52	34	41	be	be	VB
cord-048322-5eqdrd52	34	42	derived	derive	VBN
cord-048322-5eqdrd52	34	43	from	from	IN
cord-048322-5eqdrd52	34	44	long	long	JJ
cord-048322-5eqdrd52	34	45	double	double	RB
cord-048322-5eqdrd52	34	46	-	-	HYPH
cord-048322-5eqdrd52	34	47	stranded	strand	VBN
cord-048322-5eqdrd52	34	48	precursor	precursor	NN
cord-048322-5eqdrd52	34	49	molecules	molecule	NNS
cord-048322-5eqdrd52	34	50	.	.	.
cord-048322-5eqdrd52	35	1	Rather	rather	RB
cord-048322-5eqdrd52	35	2	,	,	,
cord-048322-5eqdrd52	35	3	omitting	omit	VBG
cord-048322-5eqdrd52	35	4	the	the	DT
cord-048322-5eqdrd52	35	5	initiation	initiation	NN
cord-048322-5eqdrd52	35	6	phase	phase	NN
cord-048322-5eqdrd52	35	7	,	,	,
cord-048322-5eqdrd52	35	8	they	-PRON-	PRP
cord-048322-5eqdrd52	35	9	can	can	MD
cord-048322-5eqdrd52	35	10	be	be	VB
cord-048322-5eqdrd52	35	11	delivered	deliver	VBN
cord-048322-5eqdrd52	35	12	directly	directly	RB
cord-048322-5eqdrd52	35	13	into	into	IN
cord-048322-5eqdrd52	35	14	the	the	DT
cord-048322-5eqdrd52	35	15	target	target	NN
cord-048322-5eqdrd52	35	16	cell	cell	NN
cord-048322-5eqdrd52	35	17	(	(	-LRB-
cord-048322-5eqdrd52	35	18	Figure	figure	NN
cord-048322-5eqdrd52	35	19	1	1	CD
cord-048322-5eqdrd52	35	20	,	,	,
cord-048322-5eqdrd52	35	21	upper	upper	JJ
cord-048322-5eqdrd52	35	22	right	right	JJ
cord-048322-5eqdrd52	35	23	arrow	arrow	NN
cord-048322-5eqdrd52	35	24	)	)	-RRB-
cord-048322-5eqdrd52	35	25	.	.	.
cord-048322-5eqdrd52	36	1	Several	several	JJ
cord-048322-5eqdrd52	36	2	studies	study	NNS
cord-048322-5eqdrd52	36	3	have	have	VBP
cord-048322-5eqdrd52	36	4	led	lead	VBN
cord-048322-5eqdrd52	36	5	to	to	IN
cord-048322-5eqdrd52	36	6	the	the	DT
cord-048322-5eqdrd52	36	7	development	development	NN
cord-048322-5eqdrd52	36	8	of	of	IN
cord-048322-5eqdrd52	36	9	guidelines	guideline	NNS
cord-048322-5eqdrd52	36	10	for	for	IN
cord-048322-5eqdrd52	36	11	the	the	DT
cord-048322-5eqdrd52	36	12	generation	generation	NN
cord-048322-5eqdrd52	36	13	of	of	IN
cord-048322-5eqdrd52	36	14	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	36	15	which	which	WDT
cord-048322-5eqdrd52	36	16	are	be	VBP
cord-048322-5eqdrd52	36	17	optimal	optimal	JJ
cord-048322-5eqdrd52	36	18	in	in	IN
cord-048322-5eqdrd52	36	19	terms	term	NNS
cord-048322-5eqdrd52	36	20	of	of	IN
cord-048322-5eqdrd52	36	21	efficacy	efficacy	NN
cord-048322-5eqdrd52	36	22	and	and	CC
cord-048322-5eqdrd52	36	23	specificity	specificity	NN
cord-048322-5eqdrd52	36	24	[	[	-LRB-
cord-048322-5eqdrd52	36	25	12	12	CD
cord-048322-5eqdrd52	36	26	,	,	,
cord-048322-5eqdrd52	36	27	16	16	CD
cord-048322-5eqdrd52	36	28	]	]	-RRB-
cord-048322-5eqdrd52	36	29	.	.	.
cord-048322-5eqdrd52	37	1	This	this	DT
cord-048322-5eqdrd52	37	2	includes	include	VBZ
cord-048322-5eqdrd52	37	3	the	the	DT
cord-048322-5eqdrd52	37	4	initial	initial	JJ
cord-048322-5eqdrd52	37	5	definition	definition	NN
cord-048322-5eqdrd52	37	6	of	of	IN
cord-048322-5eqdrd52	37	7	the	the	DT
cord-048322-5eqdrd52	37	8	preferable	preferable	JJ
cord-048322-5eqdrd52	37	9	length	length	NN
cord-048322-5eqdrd52	37	10	(	(	-LRB-
cord-048322-5eqdrd52	37	11	19	19	CD
cord-048322-5eqdrd52	37	12	-	-	SYM
cord-048322-5eqdrd52	37	13	25	25	CD
cord-048322-5eqdrd52	37	14	bp	bp	NNP
cord-048322-5eqdrd52	37	15	)	)	-RRB-
cord-048322-5eqdrd52	37	16	combined	combine	VBN
cord-048322-5eqdrd52	37	17	with	with	IN
cord-048322-5eqdrd52	37	18	a	a	DT
cord-048322-5eqdrd52	37	19	low	low	JJ
cord-048322-5eqdrd52	37	20	G	g	NN
cord-048322-5eqdrd52	37	21	/	/	SYM
cord-048322-5eqdrd52	37	22	C	c	NN
cord-048322-5eqdrd52	37	23	content	content	NN
cord-048322-5eqdrd52	37	24	in	in	IN
cord-048322-5eqdrd52	37	25	the	the	DT
cord-048322-5eqdrd52	37	26	range	range	NN
cord-048322-5eqdrd52	37	27	between	between	IN
cord-048322-5eqdrd52	37	28	36	36	CD
cord-048322-5eqdrd52	37	29	%	%	NN
cord-048322-5eqdrd52	37	30	and	and	CC
cord-048322-5eqdrd52	37	31	52	52	CD
cord-048322-5eqdrd52	37	32	%	%	NN
cord-048322-5eqdrd52	37	33	and	and	CC
cord-048322-5eqdrd52	37	34	the	the	DT
cord-048322-5eqdrd52	37	35	requirement	requirement	NN
cord-048322-5eqdrd52	37	36	of	of	IN
cord-048322-5eqdrd52	37	37	symmetric	symmetric	JJ
cord-048322-5eqdrd52	37	38	2	2	CD
cord-048322-5eqdrd52	37	39	nt	nt	NN
cord-048322-5eqdrd52	37	40	overhangs	overhang	NNS
cord-048322-5eqdrd52	37	41	at	at	IN
cord-048322-5eqdrd52	37	42	the	the	DT
cord-048322-5eqdrd52	37	43	3	3	CD
cord-048322-5eqdrd52	37	44	-end	-end	:
cord-048322-5eqdrd52	37	45	[	[	-LRB-
cord-048322-5eqdrd52	37	46	16	16	CD
cord-048322-5eqdrd52	37	47	]	]	-RRB-
cord-048322-5eqdrd52	37	48	[	[	-LRB-
cord-048322-5eqdrd52	37	49	17	17	CD
cord-048322-5eqdrd52	37	50	]	]	-RRB-
cord-048322-5eqdrd52	37	51	[	[	-LRB-
cord-048322-5eqdrd52	37	52	18	18	CD
cord-048322-5eqdrd52	37	53	]	]	-RRB-
cord-048322-5eqdrd52	37	54	.	.	.
cord-048322-5eqdrd52	38	1	Later	later	JJ
cord-048322-5eqdrd52	38	2	studies	study	NNS
cord-048322-5eqdrd52	38	3	on	on	IN
cord-048322-5eqdrd52	38	4	synthetic	synthetic	JJ
cord-048322-5eqdrd52	38	5	siRNA	siRNA	NNP
cord-048322-5eqdrd52	38	6	molecules	molecule	NNS
cord-048322-5eqdrd52	38	7	,	,	,
cord-048322-5eqdrd52	38	8	however	however	RB
cord-048322-5eqdrd52	38	9	,	,	,
cord-048322-5eqdrd52	38	10	revealed	reveal	VBD
cord-048322-5eqdrd52	38	11	an	an	DT
cord-048322-5eqdrd52	38	12	up	up	NN
cord-048322-5eqdrd52	38	13	to	to	TO
cord-048322-5eqdrd52	38	14	100-fold	100-fold	CD
cord-048322-5eqdrd52	38	15	higher	high	JJR
cord-048322-5eqdrd52	38	16	targeting	target	VBG
cord-048322-5eqdrd52	38	17	efficacy	efficacy	NN
cord-048322-5eqdrd52	38	18	in	in	IN
cord-048322-5eqdrd52	38	19	the	the	DT
cord-048322-5eqdrd52	38	20	case	case	NN
cord-048322-5eqdrd52	38	21	of	of	IN
cord-048322-5eqdrd52	38	22	even	even	RB
cord-048322-5eqdrd52	38	23	longer	long	JJR
cord-048322-5eqdrd52	38	24	duplexes	duplex	NNS
cord-048322-5eqdrd52	38	25	(	(	-LRB-
cord-048322-5eqdrd52	38	26	25	25	CD
cord-048322-5eqdrd52	38	27	-	-	SYM
cord-048322-5eqdrd52	38	28	30	30	CD
cord-048322-5eqdrd52	38	29	nucleotides	nucleotide	NNS
cord-048322-5eqdrd52	38	30	)	)	-RRB-
cord-048322-5eqdrd52	38	31	which	which	WDT
cord-048322-5eqdrd52	38	32	act	act	VBP
cord-048322-5eqdrd52	38	33	as	as	IN
cord-048322-5eqdrd52	38	34	a	a	DT
cord-048322-5eqdrd52	38	35	substrate	substrate	NN
cord-048322-5eqdrd52	38	36	for	for	IN
cord-048322-5eqdrd52	38	37	Dicer	Dicer	NNP
cord-048322-5eqdrd52	38	38	and	and	CC
cord-048322-5eqdrd52	38	39	which	which	WDT
cord-048322-5eqdrd52	38	40	therefore	therefore	RB
cord-048322-5eqdrd52	38	41	allow	allow	VBP
cord-048322-5eqdrd52	38	42	the	the	DT
cord-048322-5eqdrd52	38	43	direct	direct	JJ
cord-048322-5eqdrd52	38	44	incorporation	incorporation	NN
cord-048322-5eqdrd52	38	45	of	of	IN
cord-048322-5eqdrd52	38	46	the	the	DT
cord-048322-5eqdrd52	38	47	newly	newly	RB
cord-048322-5eqdrd52	38	48	produced	produce	VBN
cord-048322-5eqdrd52	38	49	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	38	50	into	into	IN
cord-048322-5eqdrd52	38	51	the	the	DT
cord-048322-5eqdrd52	38	52	RISC	RISC	NNP
cord-048322-5eqdrd52	38	53	complex	complex	JJ
cord-048322-5eqdrd52	38	54	[	[	-LRB-
cord-048322-5eqdrd52	38	55	19	19	CD
cord-048322-5eqdrd52	38	56	]	]	-RRB-
cord-048322-5eqdrd52	38	57	.	.	.
cord-048322-5eqdrd52	39	1	As	as	IN
cord-048322-5eqdrd52	39	2	to	to	TO
cord-048322-5eqdrd52	39	3	be	be	VB
cord-048322-5eqdrd52	39	4	expected	expect	VBN
cord-048322-5eqdrd52	39	5	,	,	,
cord-048322-5eqdrd52	39	6	intramolecular	intramolecular	JJ
cord-048322-5eqdrd52	39	7	foldback	foldback	NN
cord-048322-5eqdrd52	39	8	structures	structure	NNS
cord-048322-5eqdrd52	39	9	which	which	WDT
cord-048322-5eqdrd52	39	10	can	can	MD
cord-048322-5eqdrd52	39	11	result	result	VB
cord-048322-5eqdrd52	39	12	from	from	IN
cord-048322-5eqdrd52	39	13	internal	internal	JJ
cord-048322-5eqdrd52	39	14	repeats	repeat	NNS
cord-048322-5eqdrd52	39	15	or	or	CC
cord-048322-5eqdrd52	39	16	palindrome	palindrome	NN
cord-048322-5eqdrd52	39	17	sequences	sequence	NNS
cord-048322-5eqdrd52	39	18	decrease	decrease	VBP
cord-048322-5eqdrd52	39	19	the	the	DT
cord-048322-5eqdrd52	39	20	numbers	number	NNS
cord-048322-5eqdrd52	39	21	of	of	IN
cord-048322-5eqdrd52	39	22	functional	functional	JJ
cord-048322-5eqdrd52	39	23	siRNA	siRNA	NNP
cord-048322-5eqdrd52	39	24	molecules	molecule	NNS
cord-048322-5eqdrd52	39	25	with	with	IN
cord-048322-5eqdrd52	39	26	silencing	silence	VBG
cord-048322-5eqdrd52	39	27	capability	capability	NN
cord-048322-5eqdrd52	39	28	[	[	-LRB-
cord-048322-5eqdrd52	39	29	20	20	CD
cord-048322-5eqdrd52	39	30	]	]	-RRB-
cord-048322-5eqdrd52	39	31	.	.	.
cord-048322-5eqdrd52	40	1	Additional	additional	JJ
cord-048322-5eqdrd52	40	2	silencing	silencing	NN
cord-048322-5eqdrd52	40	3	-	-	HYPH
cord-048322-5eqdrd52	40	4	enhancing	enhance	VBG
cord-048322-5eqdrd52	40	5	criteria	criterion	NNS
cord-048322-5eqdrd52	40	6	include	include	VBP
cord-048322-5eqdrd52	40	7	an	an	DT
cord-048322-5eqdrd52	40	8	A	a	NN
cord-048322-5eqdrd52	40	9	in	in	IN
cord-048322-5eqdrd52	40	10	position	position	NN
cord-048322-5eqdrd52	40	11	3	3	CD
cord-048322-5eqdrd52	40	12	and	and	CC
cord-048322-5eqdrd52	40	13	a	a	DT
cord-048322-5eqdrd52	40	14	G	g	NN
cord-048322-5eqdrd52	40	15	at	at	IN
cord-048322-5eqdrd52	40	16	position	position	NN
cord-048322-5eqdrd52	40	17	13	13	CD
cord-048322-5eqdrd52	40	18	of	of	IN
cord-048322-5eqdrd52	40	19	the	the	DT
cord-048322-5eqdrd52	40	20	sense	sense	NN
cord-048322-5eqdrd52	40	21	strand	strand	NN
cord-048322-5eqdrd52	40	22	,	,	,
cord-048322-5eqdrd52	40	23	the	the	DT
cord-048322-5eqdrd52	40	24	absence	absence	NN
cord-048322-5eqdrd52	40	25	of	of	IN
cord-048322-5eqdrd52	40	26	a	a	DT
cord-048322-5eqdrd52	40	27	C	c	NN
cord-048322-5eqdrd52	40	28	or	or	CC
cord-048322-5eqdrd52	40	29	G	g	NN
cord-048322-5eqdrd52	40	30	at	at	IN
cord-048322-5eqdrd52	40	31	position	position	NN
cord-048322-5eqdrd52	40	32	19	19	CD
cord-048322-5eqdrd52	40	33	and	and	CC
cord-048322-5eqdrd52	40	34	,	,	,
cord-048322-5eqdrd52	40	35	most	most	RBS
cord-048322-5eqdrd52	40	36	importantly	importantly	RB
cord-048322-5eqdrd52	40	37	,	,	,
cord-048322-5eqdrd52	40	38	a	a	DT
cord-048322-5eqdrd52	40	39	U	u	NN
cord-048322-5eqdrd52	40	40	in	in	IN
cord-048322-5eqdrd52	40	41	position	position	NN
cord-048322-5eqdrd52	40	42	10	10	CD
cord-048322-5eqdrd52	40	43	of	of	IN
cord-048322-5eqdrd52	40	44	the	the	DT
cord-048322-5eqdrd52	40	45	sense	sense	NN
cord-048322-5eqdrd52	40	46	strand	strand	NN
cord-048322-5eqdrd52	40	47	.	.	.
cord-048322-5eqdrd52	41	1	Since	since	IN
cord-048322-5eqdrd52	41	2	nucleotides	nucleotide	NNS
cord-048322-5eqdrd52	41	3	10	10	CD
cord-048322-5eqdrd52	41	4	-	-	SYM
cord-048322-5eqdrd52	41	5	11	11	CD
cord-048322-5eqdrd52	41	6	represent	represent	VBP
cord-048322-5eqdrd52	41	7	the	the	DT
cord-048322-5eqdrd52	41	8	site	site	NN
cord-048322-5eqdrd52	41	9	of	of	IN
cord-048322-5eqdrd52	41	10	the	the	DT
cord-048322-5eqdrd52	41	11	RISC	RISC	NNP
cord-048322-5eqdrd52	41	12	-	-	HYPH
cord-048322-5eqdrd52	41	13	mediated	mediate	VBN
cord-048322-5eqdrd52	41	14	cleavage	cleavage	NN
cord-048322-5eqdrd52	41	15	of	of	IN
cord-048322-5eqdrd52	41	16	the	the	DT
cord-048322-5eqdrd52	41	17	target	target	NN
cord-048322-5eqdrd52	41	18	mRNA	mrna	NN
cord-048322-5eqdrd52	41	19	,	,	,
cord-048322-5eqdrd52	41	20	this	this	DT
cord-048322-5eqdrd52	41	21	indicates	indicate	VBZ
cord-048322-5eqdrd52	41	22	that	that	IN
cord-048322-5eqdrd52	41	23	RISC	RISC	NNP
cord-048322-5eqdrd52	41	24	is	be	VBZ
cord-048322-5eqdrd52	41	25	comparable	comparable	JJ
cord-048322-5eqdrd52	41	26	to	to	IN
cord-048322-5eqdrd52	41	27	most	most	JJS
cord-048322-5eqdrd52	41	28	other	other	JJ
cord-048322-5eqdrd52	41	29	endonucleases	endonuclease	NNS
cord-048322-5eqdrd52	41	30	in	in	IN
cord-048322-5eqdrd52	41	31	preferentially	preferentially	RB
cord-048322-5eqdrd52	41	32	cleaving	cleave	VBG
cord-048322-5eqdrd52	41	33	3	3	CD
cord-048322-5eqdrd52	41	34	of	of	IN
cord-048322-5eqdrd52	41	35	U	U	NNP
cord-048322-5eqdrd52	41	36	rather	rather	RB
cord-048322-5eqdrd52	41	37	than	than	IN
cord-048322-5eqdrd52	41	38	any	any	DT
cord-048322-5eqdrd52	41	39	other	other	JJ
cord-048322-5eqdrd52	41	40	nucleotide	nucleotide	NN
cord-048322-5eqdrd52	41	41	[	[	-LRB-
cord-048322-5eqdrd52	41	42	20	20	CD
cord-048322-5eqdrd52	41	43	,	,	,
cord-048322-5eqdrd52	41	44	21	21	CD
cord-048322-5eqdrd52	41	45	]	]	-RRB-
cord-048322-5eqdrd52	41	46	.	.	.
cord-048322-5eqdrd52	42	1	Furthermore	furthermore	RB
cord-048322-5eqdrd52	42	2	,	,	,
cord-048322-5eqdrd52	42	3	it	-PRON-	PRP
cord-048322-5eqdrd52	42	4	was	be	VBD
cord-048322-5eqdrd52	42	5	shown	show	VBN
cord-048322-5eqdrd52	42	6	more	more	RBR
cord-048322-5eqdrd52	42	7	generally	generally	RB
cord-048322-5eqdrd52	42	8	that	that	IN
cord-048322-5eqdrd52	42	9	the	the	DT
cord-048322-5eqdrd52	42	10	thermodynamic	thermodynamic	JJ
cord-048322-5eqdrd52	42	11	flexibility	flexibility	NN
cord-048322-5eqdrd52	42	12	of	of	IN
cord-048322-5eqdrd52	42	13	the	the	DT
cord-048322-5eqdrd52	42	14	positions	position	NNS
cord-048322-5eqdrd52	42	15	15	15	CD
cord-048322-5eqdrd52	42	16	-	-	SYM
cord-048322-5eqdrd52	42	17	19	19	CD
cord-048322-5eqdrd52	42	18	of	of	IN
cord-048322-5eqdrd52	42	19	the	the	DT
cord-048322-5eqdrd52	42	20	sense	sense	NN
cord-048322-5eqdrd52	42	21	strand	strand	NN
cord-048322-5eqdrd52	42	22	correlates	correlate	VBZ
cord-048322-5eqdrd52	42	23	with	with	IN
cord-048322-5eqdrd52	42	24	the	the	DT
cord-048322-5eqdrd52	42	25	silencing	silence	VBG
cord-048322-5eqdrd52	42	26	efficacy	efficacy	NN
cord-048322-5eqdrd52	42	27	and	and	CC
cord-048322-5eqdrd52	42	28	that	that	IN
cord-048322-5eqdrd52	42	29	the	the	DT
cord-048322-5eqdrd52	42	30	presence	presence	NN
cord-048322-5eqdrd52	42	31	of	of	IN
cord-048322-5eqdrd52	42	32	at	at	RB
cord-048322-5eqdrd52	42	33	least	least	JJS
cord-048322-5eqdrd52	42	34	one	one	CD
cord-048322-5eqdrd52	42	35	A	a	NN
cord-048322-5eqdrd52	42	36	/	/	SYM
cord-048322-5eqdrd52	42	37	U	u	NN
cord-048322-5eqdrd52	42	38	base	base	NN
cord-048322-5eqdrd52	42	39	pair	pair	NN
cord-048322-5eqdrd52	42	40	in	in	IN
cord-048322-5eqdrd52	42	41	this	this	DT
cord-048322-5eqdrd52	42	42	region	region	NN
cord-048322-5eqdrd52	42	43	improves	improve	VBZ
cord-048322-5eqdrd52	42	44	siRNA	siRNA	NNP
cord-048322-5eqdrd52	42	45	-	-	HYPH
cord-048322-5eqdrd52	42	46	mediated	mediate	VBN
cord-048322-5eqdrd52	42	47	silencing	silence	VBG
cord-048322-5eqdrd52	42	48	efficacy	efficacy	NN
cord-048322-5eqdrd52	42	49	due	due	IN
cord-048322-5eqdrd52	42	50	to	to	IN
cord-048322-5eqdrd52	42	51	a	a	DT
cord-048322-5eqdrd52	42	52	decreased	decrease	VBN
cord-048322-5eqdrd52	42	53	internal	internal	JJ
cord-048322-5eqdrd52	42	54	stability	stability	NN
cord-048322-5eqdrd52	42	55	of	of	IN
cord-048322-5eqdrd52	42	56	its	-PRON-	PRP$
cord-048322-5eqdrd52	42	57	3	3	CD
cord-048322-5eqdrd52	42	58	-end	-end	:
cord-048322-5eqdrd52	42	59	[	[	-LRB-
cord-048322-5eqdrd52	42	60	20	20	CD
cord-048322-5eqdrd52	42	61	]	]	-RRB-
cord-048322-5eqdrd52	42	62	.	.	.
cord-048322-5eqdrd52	43	1	Still	still	RB
cord-048322-5eqdrd52	43	2	,	,	,
cord-048322-5eqdrd52	43	3	different	different	JJ
cord-048322-5eqdrd52	43	4	siRNA	siRNA	NNP
cord-048322-5eqdrd52	43	5	sequences	sequence	NNS
cord-048322-5eqdrd52	43	6	may	may	MD
cord-048322-5eqdrd52	43	7	display	display	VB
cord-048322-5eqdrd52	43	8	differing	differ	VBG
cord-048322-5eqdrd52	43	9	efficacies	efficacy	NNS
cord-048322-5eqdrd52	43	10	,	,	,
cord-048322-5eqdrd52	43	11	which	which	WDT
cord-048322-5eqdrd52	43	12	suggest	suggest	VBP
cord-048322-5eqdrd52	43	13	additional	additional	JJ
cord-048322-5eqdrd52	43	14	still	still	RB
cord-048322-5eqdrd52	43	15	unknown	unknown	JJ
cord-048322-5eqdrd52	43	16	criteria	criterion	NNS
cord-048322-5eqdrd52	43	17	for	for	IN
cord-048322-5eqdrd52	43	18	optimal	optimal	JJ
cord-048322-5eqdrd52	43	19	siRNA	siRNA	NNP
cord-048322-5eqdrd52	43	20	selection	selection	NN
cord-048322-5eqdrd52	43	21	and	and	CC
cord-048322-5eqdrd52	43	22	emphasize	emphasize	VB
cord-048322-5eqdrd52	43	23	the	the	DT
cord-048322-5eqdrd52	43	24	influence	influence	NN
cord-048322-5eqdrd52	43	25	of	of	IN
cord-048322-5eqdrd52	43	26	target	target	NN
cord-048322-5eqdrd52	43	27	mRNA	mrna	NN
cord-048322-5eqdrd52	43	28	accessibility	accessibility	NN
cord-048322-5eqdrd52	43	29	.	.	.
cord-048322-5eqdrd52	44	1	In	in	IN
cord-048322-5eqdrd52	44	2	fact	fact	NN
cord-048322-5eqdrd52	44	3	,	,	,
cord-048322-5eqdrd52	44	4	several	several	JJ
cord-048322-5eqdrd52	44	5	studies	study	NNS
cord-048322-5eqdrd52	44	6	also	also	RB
cord-048322-5eqdrd52	44	7	correlate	correlate	VBP
cord-048322-5eqdrd52	44	8	the	the	DT
cord-048322-5eqdrd52	44	9	siRNA	siRNA	NNP
cord-048322-5eqdrd52	44	10	efficacy	efficacy	NN
cord-048322-5eqdrd52	44	11	with	with	IN
cord-048322-5eqdrd52	44	12	the	the	DT
cord-048322-5eqdrd52	44	13	mRNA	mRNA	NNP
cord-048322-5eqdrd52	44	14	secondary	secondary	JJ
cord-048322-5eqdrd52	44	15	structure	structure	NN
cord-048322-5eqdrd52	44	16	[	[	-LRB-
cord-048322-5eqdrd52	44	17	18	18	CD
cord-048322-5eqdrd52	44	18	,	,	,
cord-048322-5eqdrd52	44	19	[	[	-LRB-
cord-048322-5eqdrd52	44	20	22	22	CD
cord-048322-5eqdrd52	44	21	]	]	-RRB-
cord-048322-5eqdrd52	44	22	[	[	-LRB-
cord-048322-5eqdrd52	44	23	23	23	CD
cord-048322-5eqdrd52	44	24	]	]	-RRB-
cord-048322-5eqdrd52	44	25	[	[	-LRB-
cord-048322-5eqdrd52	44	26	24	24	CD
cord-048322-5eqdrd52	44	27	]	]	-RRB-
cord-048322-5eqdrd52	44	28	[	[	-LRB-
cord-048322-5eqdrd52	44	29	25	25	CD
cord-048322-5eqdrd52	44	30	]	]	-RRB-
cord-048322-5eqdrd52	44	31	[	[	-LRB-
cord-048322-5eqdrd52	44	32	26	26	CD
cord-048322-5eqdrd52	44	33	]	]	-RRB-
cord-048322-5eqdrd52	44	34	[	[	-LRB-
cord-048322-5eqdrd52	44	35	27	27	CD
cord-048322-5eqdrd52	44	36	]	]	-RRB-
cord-048322-5eqdrd52	44	37	.	.	.
cord-048322-5eqdrd52	45	1	In	in	IN
cord-048322-5eqdrd52	45	2	conclusion	conclusion	NN
cord-048322-5eqdrd52	45	3	,	,	,
cord-048322-5eqdrd52	45	4	apart	apart	RB
cord-048322-5eqdrd52	45	5	from	from	IN
cord-048322-5eqdrd52	45	6	the	the	DT
cord-048322-5eqdrd52	45	7	selection	selection	NN
cord-048322-5eqdrd52	45	8	criteria	criterion	NNS
cord-048322-5eqdrd52	45	9	defined	define	VBN
cord-048322-5eqdrd52	45	10	above	above	RB
cord-048322-5eqdrd52	45	11	,	,	,
cord-048322-5eqdrd52	45	12	the	the	DT
cord-048322-5eqdrd52	45	13	individual	individual	JJ
cord-048322-5eqdrd52	45	14	screening	screening	NN
cord-048322-5eqdrd52	45	15	of	of	IN
cord-048322-5eqdrd52	45	16	different	different	JJ
cord-048322-5eqdrd52	45	17	siRNAs	sirna	NNS
cord-048322-5eqdrd52	45	18	for	for	IN
cord-048322-5eqdrd52	45	19	highly	highly	RB
cord-048322-5eqdrd52	45	20	efficient	efficient	JJ
cord-048322-5eqdrd52	45	21	and	and	CC
cord-048322-5eqdrd52	45	22	specific	specific	JJ
cord-048322-5eqdrd52	45	23	duplexes	duplex	NNS
cord-048322-5eqdrd52	45	24	,	,	,
cord-048322-5eqdrd52	45	25	or	or	CC
cord-048322-5eqdrd52	45	26	the	the	DT
cord-048322-5eqdrd52	45	27	pooling	pooling	NN
cord-048322-5eqdrd52	45	28	of	of	IN
cord-048322-5eqdrd52	45	29	multiple	multiple	JJ
cord-048322-5eqdrd52	45	30	siRNAs	sirna	NNS
cord-048322-5eqdrd52	45	31	,	,	,
cord-048322-5eqdrd52	45	32	is	be	VBZ
cord-048322-5eqdrd52	45	33	the	the	DT
cord-048322-5eqdrd52	45	34	most	most	RBS
cord-048322-5eqdrd52	45	35	effective	effective	JJ
cord-048322-5eqdrd52	45	36	approach	approach	NN
cord-048322-5eqdrd52	45	37	to	to	TO
cord-048322-5eqdrd52	45	38	increase	increase	VB
cord-048322-5eqdrd52	45	39	siRNAmediated	sirnamediate	VBN
cord-048322-5eqdrd52	45	40	targeting	target	VBG
cord-048322-5eqdrd52	45	41	efficacy	efficacy	NN
cord-048322-5eqdrd52	45	42	.	.	.
cord-048322-5eqdrd52	46	1	For	for	IN
cord-048322-5eqdrd52	46	2	the	the	DT
cord-048322-5eqdrd52	46	3	design	design	NN
cord-048322-5eqdrd52	46	4	of	of	IN
cord-048322-5eqdrd52	46	5	effective	effective	JJ
cord-048322-5eqdrd52	46	6	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	46	7	,	,	,
cord-048322-5eqdrd52	46	8	several	several	JJ
cord-048322-5eqdrd52	46	9	algorithms	algorithm	NNS
cord-048322-5eqdrd52	46	10	on	on	IN
cord-048322-5eqdrd52	46	11	publicly	publicly	RB
cord-048322-5eqdrd52	46	12	accessible	accessible	JJ
cord-048322-5eqdrd52	46	13	web	web	NN
cord-048322-5eqdrd52	46	14	sites	site	NNS
cord-048322-5eqdrd52	46	15	are	be	VBP
cord-048322-5eqdrd52	46	16	available	available	JJ
cord-048322-5eqdrd52	46	17	(	(	-LRB-
cord-048322-5eqdrd52	46	18	see	see	VB
cord-048322-5eqdrd52	46	19	[	[	-LRB-
cord-048322-5eqdrd52	46	20	28	28	CD
cord-048322-5eqdrd52	46	21	]	]	-RRB-
cord-048322-5eqdrd52	46	22	for	for	IN
cord-048322-5eqdrd52	46	23	review	review	NN
cord-048322-5eqdrd52	46	24	)	)	-RRB-
cord-048322-5eqdrd52	46	25	.	.	.
cord-048322-5eqdrd52	47	1	To	to	TO
cord-048322-5eqdrd52	47	2	reduce	reduce	VB
cord-048322-5eqdrd52	47	3	the	the	DT
cord-048322-5eqdrd52	47	4	risk	risk	NN
cord-048322-5eqdrd52	47	5	of	of	IN
cord-048322-5eqdrd52	47	6	nonspecific	nonspecific	JJ
cord-048322-5eqdrd52	47	7	(	(	-LRB-
cord-048322-5eqdrd52	47	8	"	"	``
cord-048322-5eqdrd52	47	9	off	off	IN
cord-048322-5eqdrd52	47	10	-	-	HYPH
cord-048322-5eqdrd52	47	11	target	target	NN
cord-048322-5eqdrd52	47	12	"	"	''
cord-048322-5eqdrd52	47	13	)	)	-RRB-
cord-048322-5eqdrd52	47	14	effects	effect	NNS
cord-048322-5eqdrd52	47	15	of	of	IN
cord-048322-5eqdrd52	47	16	the	the	DT
cord-048322-5eqdrd52	47	17	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	47	18	,	,	,
cord-048322-5eqdrd52	47	19	a	a	DT
cord-048322-5eqdrd52	47	20	homology	homology	NN
cord-048322-5eqdrd52	47	21	search	search	NN
cord-048322-5eqdrd52	47	22	of	of	IN
cord-048322-5eqdrd52	47	23	the	the	DT
cord-048322-5eqdrd52	47	24	targeting	targeting	NN
cord-048322-5eqdrd52	47	25	sequence	sequence	NN
cord-048322-5eqdrd52	47	26	against	against	IN
cord-048322-5eqdrd52	47	27	a	a	DT
cord-048322-5eqdrd52	47	28	gene	gene	NN
cord-048322-5eqdrd52	47	29	database	database	NN
cord-048322-5eqdrd52	47	30	is	be	VBZ
cord-048322-5eqdrd52	47	31	necessary	necessary	JJ
cord-048322-5eqdrd52	47	32	and	and	CC
cord-048322-5eqdrd52	47	33	already	already	RB
cord-048322-5eqdrd52	47	34	incorporated	incorporate	VBN
cord-048322-5eqdrd52	47	35	in	in	IN
cord-048322-5eqdrd52	47	36	some	some	DT
cord-048322-5eqdrd52	47	37	of	of	IN
cord-048322-5eqdrd52	47	38	these	these	DT
cord-048322-5eqdrd52	47	39	web	web	NN
cord-048322-5eqdrd52	47	40	sites	site	NNS
cord-048322-5eqdrd52	47	41	.	.	.
cord-048322-5eqdrd52	48	1	Nevertheless	nevertheless	RB
cord-048322-5eqdrd52	48	2	,	,	,
cord-048322-5eqdrd52	48	3	it	-PRON-	PRP
cord-048322-5eqdrd52	48	4	has	have	VBZ
cord-048322-5eqdrd52	48	5	also	also	RB
cord-048322-5eqdrd52	48	6	been	be	VBN
cord-048322-5eqdrd52	48	7	shown	show	VBN
cord-048322-5eqdrd52	48	8	that	that	IN
cord-048322-5eqdrd52	48	9	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	48	10	may	may	MD
cord-048322-5eqdrd52	48	11	cross	cross	VB
cord-048322-5eqdrd52	48	12	-	-	VB
cord-048322-5eqdrd52	48	13	react	react	VB
cord-048322-5eqdrd52	48	14	with	with	IN
cord-048322-5eqdrd52	48	15	targets	target	NNS
cord-048322-5eqdrd52	48	16	of	of	IN
cord-048322-5eqdrd52	48	17	limited	limited	JJ
cord-048322-5eqdrd52	48	18	sequence	sequence	NN
cord-048322-5eqdrd52	48	19	similarity	similarity	NN
cord-048322-5eqdrd52	48	20	when	when	WRB
cord-048322-5eqdrd52	48	21	regions	region	NNS
cord-048322-5eqdrd52	48	22	of	of	IN
cord-048322-5eqdrd52	48	23	partial	partial	JJ
cord-048322-5eqdrd52	48	24	sequence	sequence	NN
cord-048322-5eqdrd52	48	25	identity	identity	NN
cord-048322-5eqdrd52	48	26	between	between	IN
cord-048322-5eqdrd52	48	27	the	the	DT
cord-048322-5eqdrd52	48	28	target	target	NN
cord-048322-5eqdrd52	48	29	mRNA	mrna	NN
cord-048322-5eqdrd52	48	30	and	and	CC
cord-048322-5eqdrd52	48	31	the	the	DT
cord-048322-5eqdrd52	48	32	siRNA	siRNA	NNP
cord-048322-5eqdrd52	48	33	exist	exist	VBP
cord-048322-5eqdrd52	48	34	.	.	.
cord-048322-5eqdrd52	49	1	In	in	IN
cord-048322-5eqdrd52	49	2	fact	fact	NN
cord-048322-5eqdrd52	49	3	,	,	,
cord-048322-5eqdrd52	49	4	in	in	IN
cord-048322-5eqdrd52	49	5	some	some	DT
cord-048322-5eqdrd52	49	6	cases	case	NNS
cord-048322-5eqdrd52	49	7	regions	region	NNS
cord-048322-5eqdrd52	49	8	comprising	comprise	VBG
cord-048322-5eqdrd52	49	9	of	of	IN
cord-048322-5eqdrd52	49	10	only	only	RB
cord-048322-5eqdrd52	49	11	11	11	CD
cord-048322-5eqdrd52	49	12	-	-	SYM
cord-048322-5eqdrd52	49	13	15	15	CD
cord-048322-5eqdrd52	49	14	contiguous	contiguous	JJ
cord-048322-5eqdrd52	49	15	nucleotides	nucleotide	NNS
cord-048322-5eqdrd52	49	16	of	of	IN
cord-048322-5eqdrd52	49	17	sequence	sequence	NN
cord-048322-5eqdrd52	49	18	identity	identity	NN
cord-048322-5eqdrd52	49	19	were	be	VBD
cord-048322-5eqdrd52	49	20	sufficient	sufficient	JJ
cord-048322-5eqdrd52	49	21	to	to	TO
cord-048322-5eqdrd52	49	22	induce	induce	VB
cord-048322-5eqdrd52	49	23	gene	gene	NN
cord-048322-5eqdrd52	49	24	silencing	silence	VBG
cord-048322-5eqdrd52	49	25	[	[	-LRB-
cord-048322-5eqdrd52	49	26	29	29	CD
cord-048322-5eqdrd52	49	27	]	]	-RRB-
cord-048322-5eqdrd52	49	28	.	.	.
cord-048322-5eqdrd52	50	1	The	the	DT
cord-048322-5eqdrd52	50	2	prediction	prediction	NN
cord-048322-5eqdrd52	50	3	of	of	IN
cord-048322-5eqdrd52	50	4	these	these	DT
cord-048322-5eqdrd52	50	5	off	off	IN
cord-048322-5eqdrd52	50	6	-	-	HYPH
cord-048322-5eqdrd52	50	7	target	target	NN
cord-048322-5eqdrd52	50	8	activities	activity	NNS
cord-048322-5eqdrd52	50	9	is	be	VBZ
cord-048322-5eqdrd52	50	10	difficult	difficult	JJ
cord-048322-5eqdrd52	50	11	so	so	RB
cord-048322-5eqdrd52	50	12	far	far	RB
cord-048322-5eqdrd52	50	13	.	.	.
cord-048322-5eqdrd52	51	1	An	an	DT
cord-048322-5eqdrd52	51	2	additional	additional	JJ
cord-048322-5eqdrd52	51	3	mechanism	mechanism	NN
cord-048322-5eqdrd52	51	4	that	that	WDT
cord-048322-5eqdrd52	51	5	may	may	MD
cord-048322-5eqdrd52	51	6	lead	lead	VB
cord-048322-5eqdrd52	51	7	to	to	IN
cord-048322-5eqdrd52	51	8	nonspecific	nonspecific	JJ
cord-048322-5eqdrd52	51	9	effects	effect	NNS
cord-048322-5eqdrd52	51	10	in	in	IN
cord-048322-5eqdrd52	51	11	vivo	vivo	NN
cord-048322-5eqdrd52	51	12	relies	rely	VBZ
cord-048322-5eqdrd52	51	13	on	on	IN
cord-048322-5eqdrd52	51	14	the	the	DT
cord-048322-5eqdrd52	51	15	interferon	interferon	NN
cord-048322-5eqdrd52	51	16	system	system	NN
cord-048322-5eqdrd52	51	17	[	[	-LRB-
cord-048322-5eqdrd52	51	18	30	30	CD
cord-048322-5eqdrd52	51	19	]	]	-RRB-
cord-048322-5eqdrd52	51	20	[	[	-LRB-
cord-048322-5eqdrd52	51	21	31	31	CD
cord-048322-5eqdrd52	51	22	]	]	-RRB-
cord-048322-5eqdrd52	52	1	[	[	-LRB-
cord-048322-5eqdrd52	52	2	32	32	CD
cord-048322-5eqdrd52	52	3	]	]	-RRB-
cord-048322-5eqdrd52	53	1	[	[	-LRB-
cord-048322-5eqdrd52	53	2	33	33	CD
cord-048322-5eqdrd52	53	3	]	]	-RRB-
cord-048322-5eqdrd52	53	4	which	which	WDT
cord-048322-5eqdrd52	53	5	is	be	VBZ
cord-048322-5eqdrd52	53	6	induced	induce	VBN
cord-048322-5eqdrd52	53	7	when	when	WRB
cord-048322-5eqdrd52	53	8	double	double	RB
cord-048322-5eqdrd52	53	9	-	-	HYPH
cord-048322-5eqdrd52	53	10	stranded	strand	VBN
cord-048322-5eqdrd52	53	11	RNA	RNA	NNP
cord-048322-5eqdrd52	53	12	molecules	molecule	NNS
cord-048322-5eqdrd52	53	13	enter	enter	VBP
cord-048322-5eqdrd52	53	14	a	a	DT
cord-048322-5eqdrd52	53	15	cell	cell	NN
cord-048322-5eqdrd52	53	16	activating	activate	VBG
cord-048322-5eqdrd52	53	17	a	a	DT
cord-048322-5eqdrd52	53	18	multi	multi	JJ
cord-048322-5eqdrd52	53	19	-	-	JJ
cord-048322-5eqdrd52	53	20	component	component	JJ
cord-048322-5eqdrd52	53	21	signalling	signalling	NN
cord-048322-5eqdrd52	53	22	complex	complex	NN
cord-048322-5eqdrd52	53	23	.	.	.
cord-048322-5eqdrd52	54	1	This	this	DT
cord-048322-5eqdrd52	54	2	effect	effect	NN
cord-048322-5eqdrd52	54	3	is	be	VBZ
cord-048322-5eqdrd52	54	4	particularly	particularly	RB
cord-048322-5eqdrd52	54	5	true	true	JJ
cord-048322-5eqdrd52	54	6	for	for	IN
cord-048322-5eqdrd52	54	7	long	long	JJ
cord-048322-5eqdrd52	54	8	dsRNA	dsrna	NN
cord-048322-5eqdrd52	54	9	molecules	molecule	NNS
cord-048322-5eqdrd52	54	10	and	and	CC
cord-048322-5eqdrd52	54	11	essentially	essentially	RB
cord-048322-5eqdrd52	54	12	prevents	prevent	VBZ
cord-048322-5eqdrd52	54	13	them	-PRON-	PRP
cord-048322-5eqdrd52	54	14	from	from	IN
cord-048322-5eqdrd52	54	15	being	be	VBG
cord-048322-5eqdrd52	54	16	used	use	VBN
cord-048322-5eqdrd52	54	17	as	as	IN
cord-048322-5eqdrd52	54	18	inducers	inducer	NNS
cord-048322-5eqdrd52	54	19	of	of	IN
cord-048322-5eqdrd52	54	20	RNA	RNA	NNP
cord-048322-5eqdrd52	54	21	interference	interference	NN
cord-048322-5eqdrd52	54	22	in	in	IN
cord-048322-5eqdrd52	54	23	mammalian	mammalian	JJ
cord-048322-5eqdrd52	54	24	systems	system	NNS
cord-048322-5eqdrd52	54	25	.	.	.
cord-048322-5eqdrd52	55	1	The	the	DT
cord-048322-5eqdrd52	55	2	development	development	NN
cord-048322-5eqdrd52	55	3	of	of	IN
cord-048322-5eqdrd52	55	4	synthetic	synthetic	JJ
cord-048322-5eqdrd52	55	5	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	55	6	[	[	-LRB-
cord-048322-5eqdrd52	55	7	10	10	CD
cord-048322-5eqdrd52	55	8	,	,	,
cord-048322-5eqdrd52	55	9	12	12	CD
cord-048322-5eqdrd52	55	10	,	,	,
cord-048322-5eqdrd52	55	11	33	33	CD
cord-048322-5eqdrd52	55	12	,	,	,
cord-048322-5eqdrd52	55	13	34	34	CD
cord-048322-5eqdrd52	55	14	]	]	-RRB-
cord-048322-5eqdrd52	55	15	largely	largely	RB
cord-048322-5eqdrd52	55	16	circumvents	circumvent	VBZ
cord-048322-5eqdrd52	55	17	this	this	DT
cord-048322-5eqdrd52	55	18	problem	problem	NN
cord-048322-5eqdrd52	55	19	since	since	IN
cord-048322-5eqdrd52	55	20	they	-PRON-	PRP
cord-048322-5eqdrd52	55	21	seem	seem	VBP
cord-048322-5eqdrd52	55	22	to	to	TO
cord-048322-5eqdrd52	55	23	be	be	VB
cord-048322-5eqdrd52	55	24	too	too	RB
cord-048322-5eqdrd52	55	25	small	small	JJ
cord-048322-5eqdrd52	55	26	.	.	.
cord-048322-5eqdrd52	56	1	However	however	RB
cord-048322-5eqdrd52	56	2	,	,	,
cord-048322-5eqdrd52	56	3	some	some	DT
cord-048322-5eqdrd52	56	4	synthetic	synthetic	JJ
cord-048322-5eqdrd52	56	5	siR	siR	NNP
cord-048322-5eqdrd52	56	6	-	-	HYPH
cord-048322-5eqdrd52	56	7	NAs	na	NNS
cord-048322-5eqdrd52	56	8	do	do	VBP
cord-048322-5eqdrd52	56	9	induce	induce	VB
cord-048322-5eqdrd52	56	10	components	component	NNS
cord-048322-5eqdrd52	56	11	of	of	IN
cord-048322-5eqdrd52	56	12	the	the	DT
cord-048322-5eqdrd52	56	13	interferon	interferon	NN
cord-048322-5eqdrd52	56	14	system	system	NN
cord-048322-5eqdrd52	56	15	which	which	WDT
cord-048322-5eqdrd52	56	16	seems	seem	VBZ
cord-048322-5eqdrd52	56	17	to	to	TO
cord-048322-5eqdrd52	56	18	be	be	VB
cord-048322-5eqdrd52	56	19	dependent	dependent	JJ
cord-048322-5eqdrd52	56	20	on	on	IN
cord-048322-5eqdrd52	56	21	their	-PRON-	PRP$
cord-048322-5eqdrd52	56	22	sequence	sequence	NN
cord-048322-5eqdrd52	56	23	[	[	-LRB-
cord-048322-5eqdrd52	56	24	31	31	CD
cord-048322-5eqdrd52	56	25	,	,	,
cord-048322-5eqdrd52	56	26	32	32	CD
cord-048322-5eqdrd52	56	27	,	,	,
cord-048322-5eqdrd52	56	28	35	35	CD
cord-048322-5eqdrd52	56	29	]	]	-RRB-
cord-048322-5eqdrd52	56	30	as	as	RB
cord-048322-5eqdrd52	56	31	well	well	RB
cord-048322-5eqdrd52	56	32	as	as	IN
cord-048322-5eqdrd52	56	33	,	,	,
cord-048322-5eqdrd52	56	34	in	in	IN
cord-048322-5eqdrd52	56	35	the	the	DT
cord-048322-5eqdrd52	56	36	case	case	NN
cord-048322-5eqdrd52	56	37	of	of	IN
cord-048322-5eqdrd52	56	38	in	in	FW
cord-048322-5eqdrd52	56	39	vitro	vitro	FW
cord-048322-5eqdrd52	56	40	transcribed	transcribe	VBN
cord-048322-5eqdrd52	56	41	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	56	42	,	,	,
cord-048322-5eqdrd52	56	43	on	on	IN
cord-048322-5eqdrd52	56	44	the	the	DT
cord-048322-5eqdrd52	56	45	5	5	CD
cord-048322-5eqdrd52	56	46	initiating	initiating	NN
cord-048322-5eqdrd52	56	47	triphosphate	triphosphate	NN
cord-048322-5eqdrd52	56	48	[	[	-LRB-
cord-048322-5eqdrd52	56	49	36	36	CD
cord-048322-5eqdrd52	56	50	]	]	-RRB-
cord-048322-5eqdrd52	56	51	.	.	.
cord-048322-5eqdrd52	57	1	Thus	thus	RB
cord-048322-5eqdrd52	57	2	,	,	,
cord-048322-5eqdrd52	57	3	strategies	strategy	NNS
cord-048322-5eqdrd52	57	4	to	to	TO
cord-048322-5eqdrd52	57	5	avoid	avoid	VB
cord-048322-5eqdrd52	57	6	as	as	RB
cord-048322-5eqdrd52	57	7	far	far	RB
cord-048322-5eqdrd52	57	8	as	as	IN
cord-048322-5eqdrd52	57	9	possible	possible	JJ
cord-048322-5eqdrd52	57	10	the	the	DT
cord-048322-5eqdrd52	57	11	unwanted	unwanted	JJ
cord-048322-5eqdrd52	57	12	interferon	interferon	NN
cord-048322-5eqdrd52	57	13	response	response	NN
cord-048322-5eqdrd52	57	14	upon	upon	IN
cord-048322-5eqdrd52	57	15	application	application	NN
cord-048322-5eqdrd52	57	16	of	of	IN
cord-048322-5eqdrd52	57	17	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	57	18	in	in	IN
cord-048322-5eqdrd52	57	19	vivo	vivo	NN
cord-048322-5eqdrd52	57	20	will	will	MD
cord-048322-5eqdrd52	57	21	include	include	VB
cord-048322-5eqdrd52	57	22	a	a	DT
cord-048322-5eqdrd52	57	23	design	design	NN
cord-048322-5eqdrd52	57	24	of	of	IN
cord-048322-5eqdrd52	57	25	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	57	26	without	without	IN
cord-048322-5eqdrd52	57	27	known	know	VBN
cord-048322-5eqdrd52	57	28	interferon	interferon	NN
cord-048322-5eqdrd52	57	29	-	-	HYPH
cord-048322-5eqdrd52	57	30	stimulating	stimulate	VBG
cord-048322-5eqdrd52	57	31	sequences	sequence	NNS
cord-048322-5eqdrd52	57	32	,	,	,
cord-048322-5eqdrd52	57	33	the	the	DT
cord-048322-5eqdrd52	57	34	use	use	NN
cord-048322-5eqdrd52	57	35	of	of	IN
cord-048322-5eqdrd52	57	36	the	the	DT
cord-048322-5eqdrd52	57	37	lowest	low	JJS
cord-048322-5eqdrd52	57	38	possible	possible	JJ
cord-048322-5eqdrd52	57	39	siRNA	siRNA	NNP
cord-048322-5eqdrd52	57	40	dose	dose	NN
cord-048322-5eqdrd52	57	41	to	to	TO
cord-048322-5eqdrd52	57	42	still	still	RB
cord-048322-5eqdrd52	57	43	achieve	achieve	VB
cord-048322-5eqdrd52	57	44	the	the	DT
cord-048322-5eqdrd52	57	45	desired	desire	VBN
cord-048322-5eqdrd52	57	46	effect	effect	NN
cord-048322-5eqdrd52	57	47	and	and	CC
cord-048322-5eqdrd52	57	48	optimized	optimize	VBN
cord-048322-5eqdrd52	57	49	siRNA	siRNA	NNP
cord-048322-5eqdrd52	57	50	delivery	delivery	NN
cord-048322-5eqdrd52	57	51	methods	method	NNS
cord-048322-5eqdrd52	57	52	.	.	.
cord-048322-5eqdrd52	58	1	Based	base	VBN
cord-048322-5eqdrd52	58	2	on	on	IN
cord-048322-5eqdrd52	58	3	the	the	DT
cord-048322-5eqdrd52	58	4	known	know	VBN
cord-048322-5eqdrd52	58	5	mechanisms	mechanism	NNS
cord-048322-5eqdrd52	58	6	of	of	IN
cord-048322-5eqdrd52	58	7	antisense	antisense	NN
cord-048322-5eqdrd52	58	8	technology	technology	NN
cord-048322-5eqdrd52	58	9	,	,	,
cord-048322-5eqdrd52	58	10	ribozyme	ribozyme	NN
cord-048322-5eqdrd52	58	11	-	-	HYPH
cord-048322-5eqdrd52	58	12	targeting	target	VBG
cord-048322-5eqdrd52	58	13	or	or	CC
cord-048322-5eqdrd52	58	14	RNAi	RNAi	NNS
cord-048322-5eqdrd52	58	15	,	,	,
cord-048322-5eqdrd52	58	16	small	small	JJ
cord-048322-5eqdrd52	58	17	oligonucleotides	oligonucleotide	NNS
cord-048322-5eqdrd52	58	18	or	or	CC
cord-048322-5eqdrd52	58	19	plasmid	plasmid	NN
cord-048322-5eqdrd52	58	20	-	-	HYPH
cord-048322-5eqdrd52	58	21	based	base	VBN
cord-048322-5eqdrd52	58	22	expression	expression	NN
cord-048322-5eqdrd52	58	23	vectors	vector	NNS
cord-048322-5eqdrd52	58	24	can	can	MD
cord-048322-5eqdrd52	58	25	be	be	VB
cord-048322-5eqdrd52	58	26	used	use	VBN
cord-048322-5eqdrd52	58	27	to	to	TO
cord-048322-5eqdrd52	58	28	specifically	specifically	RB
cord-048322-5eqdrd52	58	29	downregulate	downregulate	VB
cord-048322-5eqdrd52	58	30	the	the	DT
cord-048322-5eqdrd52	58	31	expression	expression	NN
cord-048322-5eqdrd52	58	32	of	of	IN
cord-048322-5eqdrd52	58	33	a	a	DT
cord-048322-5eqdrd52	58	34	given	give	VBN
cord-048322-5eqdrd52	58	35	gene	gene	NN
cord-048322-5eqdrd52	58	36	of	of	IN
cord-048322-5eqdrd52	58	37	interest	interest	NN
cord-048322-5eqdrd52	58	38	or	or	CC
cord-048322-5eqdrd52	58	39	of	of	IN
cord-048322-5eqdrd52	58	40	pathological	pathological	JJ
cord-048322-5eqdrd52	58	41	relevance	relevance	NN
cord-048322-5eqdrd52	58	42	in	in	IN
cord-048322-5eqdrd52	58	43	vitro	vitro	FW
cord-048322-5eqdrd52	58	44	.	.	.
cord-048322-5eqdrd52	59	1	In	in	IN
cord-048322-5eqdrd52	59	2	principle	principle	NN
cord-048322-5eqdrd52	59	3	,	,	,
cord-048322-5eqdrd52	59	4	this	this	DT
cord-048322-5eqdrd52	59	5	also	also	RB
cord-048322-5eqdrd52	59	6	applies	apply	VBZ
cord-048322-5eqdrd52	59	7	to	to	IN
cord-048322-5eqdrd52	59	8	the	the	DT
cord-048322-5eqdrd52	59	9	in	in	IN
cord-048322-5eqdrd52	59	10	vivo	vivo	NN
cord-048322-5eqdrd52	59	11	situation	situation	NN
cord-048322-5eqdrd52	59	12	leading	lead	VBG
cord-048322-5eqdrd52	59	13	to	to	IN
cord-048322-5eqdrd52	59	14	novel	novel	NN
cord-048322-5eqdrd52	59	15	,	,	,
cord-048322-5eqdrd52	59	16	potentially	potentially	RB
cord-048322-5eqdrd52	59	17	relevant	relevant	JJ
cord-048322-5eqdrd52	59	18	therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	59	19	approaches	approach	NNS
cord-048322-5eqdrd52	59	20	.	.	.
cord-048322-5eqdrd52	60	1	For	for	IN
cord-048322-5eqdrd52	60	2	the	the	DT
cord-048322-5eqdrd52	60	3	delivery	delivery	NN
cord-048322-5eqdrd52	60	4	of	of	IN
cord-048322-5eqdrd52	60	5	therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	60	6	nucleic	nucleic	JJ
cord-048322-5eqdrd52	60	7	acids	acid	NNS
cord-048322-5eqdrd52	60	8	,	,	,
cord-048322-5eqdrd52	60	9	viral	viral	JJ
cord-048322-5eqdrd52	60	10	vectors	vector	NNS
cord-048322-5eqdrd52	60	11	have	have	VBP
cord-048322-5eqdrd52	60	12	been	be	VBN
cord-048322-5eqdrd52	60	13	used	use	VBN
cord-048322-5eqdrd52	60	14	which	which	WDT
cord-048322-5eqdrd52	60	15	have	have	VB
cord-048322-5eqdrd52	60	16	the	the	DT
cord-048322-5eqdrd52	60	17	advantage	advantage	NN
cord-048322-5eqdrd52	60	18	of	of	IN
cord-048322-5eqdrd52	60	19	high	high	JJ
cord-048322-5eqdrd52	60	20	transfection	transfection	NN
cord-048322-5eqdrd52	60	21	efficacy	efficacy	NN
cord-048322-5eqdrd52	60	22	due	due	IN
cord-048322-5eqdrd52	60	23	to	to	IN
cord-048322-5eqdrd52	60	24	the	the	DT
cord-048322-5eqdrd52	60	25	inherent	inherent	JJ
cord-048322-5eqdrd52	60	26	ability	ability	NN
cord-048322-5eqdrd52	60	27	of	of	IN
cord-048322-5eqdrd52	60	28	viruses	virus	NNS
cord-048322-5eqdrd52	60	29	to	to	TO
cord-048322-5eqdrd52	60	30	transport	transport	VB
cord-048322-5eqdrd52	60	31	genetic	genetic	JJ
cord-048322-5eqdrd52	60	32	material	material	NN
cord-048322-5eqdrd52	60	33	into	into	IN
cord-048322-5eqdrd52	60	34	cells	cell	NNS
cord-048322-5eqdrd52	60	35	.	.	.
cord-048322-5eqdrd52	61	1	On	on	IN
cord-048322-5eqdrd52	61	2	the	the	DT
cord-048322-5eqdrd52	61	3	other	other	JJ
cord-048322-5eqdrd52	61	4	hand	hand	NN
cord-048322-5eqdrd52	61	5	,	,	,
cord-048322-5eqdrd52	61	6	however	however	RB
cord-048322-5eqdrd52	61	7	,	,	,
cord-048322-5eqdrd52	61	8	viral	viral	JJ
cord-048322-5eqdrd52	61	9	systems	system	NNS
cord-048322-5eqdrd52	61	10	show	show	VBP
cord-048322-5eqdrd52	61	11	a	a	DT
cord-048322-5eqdrd52	61	12	limited	limited	JJ
cord-048322-5eqdrd52	61	13	loading	loading	NN
cord-048322-5eqdrd52	61	14	capacity	capacity	NN
cord-048322-5eqdrd52	61	15	regarding	regard	VBG
cord-048322-5eqdrd52	61	16	that	that	IN
cord-048322-5eqdrd52	61	17	the	the	DT
cord-048322-5eqdrd52	61	18	genetic	genetic	JJ
cord-048322-5eqdrd52	61	19	material	material	NN
cord-048322-5eqdrd52	61	20	are	be	VBP
cord-048322-5eqdrd52	61	21	rather	rather	RB
cord-048322-5eqdrd52	61	22	difficult	difficult	JJ
cord-048322-5eqdrd52	61	23	to	to	TO
cord-048322-5eqdrd52	61	24	produce	produce	VB
cord-048322-5eqdrd52	61	25	in	in	IN
cord-048322-5eqdrd52	61	26	a	a	DT
cord-048322-5eqdrd52	61	27	larger	large	JJR
cord-048322-5eqdrd52	61	28	scale	scale	NN
cord-048322-5eqdrd52	61	29	and	and	CC
cord-048322-5eqdrd52	61	30	,	,	,
cord-048322-5eqdrd52	61	31	most	most	RBS
cord-048322-5eqdrd52	61	32	importantly	importantly	RB
cord-048322-5eqdrd52	61	33	,	,	,
cord-048322-5eqdrd52	61	34	pose	pose	VBP
cord-048322-5eqdrd52	61	35	severe	severe	JJ
cord-048322-5eqdrd52	61	36	safety	safety	NN
cord-048322-5eqdrd52	61	37	risks	risk	NNS
cord-048322-5eqdrd52	61	38	due	due	IN
cord-048322-5eqdrd52	61	39	to	to	IN
cord-048322-5eqdrd52	61	40	their	-PRON-	PRP$
cord-048322-5eqdrd52	61	41	oncogenic	oncogenic	JJ
cord-048322-5eqdrd52	61	42	potential	potential	NN
cord-048322-5eqdrd52	61	43	and	and	CC
cord-048322-5eqdrd52	61	44	their	-PRON-	PRP$
cord-048322-5eqdrd52	61	45	inflammatory	inflammatory	JJ
cord-048322-5eqdrd52	61	46	and	and	CC
cord-048322-5eqdrd52	61	47	immunogenic	immunogenic	JJ
cord-048322-5eqdrd52	61	48	effects	effect	NNS
cord-048322-5eqdrd52	61	49	which	which	WDT
cord-048322-5eqdrd52	61	50	prevent	prevent	VBP
cord-048322-5eqdrd52	61	51	them	-PRON-	PRP
cord-048322-5eqdrd52	61	52	from	from	IN
cord-048322-5eqdrd52	61	53	repeated	repeat	VBN
cord-048322-5eqdrd52	61	54	administration	administration	NN
cord-048322-5eqdrd52	61	55	[	[	-LRB-
cord-048322-5eqdrd52	61	56	37	37	CD
cord-048322-5eqdrd52	61	57	]	]	-RRB-
cord-048322-5eqdrd52	61	58	[	[	-LRB-
cord-048322-5eqdrd52	61	59	38	38	CD
cord-048322-5eqdrd52	61	60	]	]	-RRB-
cord-048322-5eqdrd52	61	61	[	[	-LRB-
cord-048322-5eqdrd52	61	62	39	39	CD
cord-048322-5eqdrd52	61	63	]	]	-RRB-
cord-048322-5eqdrd52	61	64	[	[	-LRB-
cord-048322-5eqdrd52	61	65	40	40	CD
cord-048322-5eqdrd52	61	66	]	]	-RRB-
cord-048322-5eqdrd52	61	67	.	.	.
cord-048322-5eqdrd52	62	1	In	in	IN
cord-048322-5eqdrd52	62	2	the	the	DT
cord-048322-5eqdrd52	62	3	light	light	NN
cord-048322-5eqdrd52	62	4	of	of	IN
cord-048322-5eqdrd52	62	5	these	these	DT
cord-048322-5eqdrd52	62	6	problems	problem	NNS
cord-048322-5eqdrd52	62	7	,	,	,
cord-048322-5eqdrd52	62	8	concerns	concern	NNS
cord-048322-5eqdrd52	62	9	,	,	,
cord-048322-5eqdrd52	62	10	and	and	CC
cord-048322-5eqdrd52	62	11	limitations	limitation	NNS
cord-048322-5eqdrd52	62	12	,	,	,
cord-048322-5eqdrd52	62	13	nonviral	nonviral	JJ
cord-048322-5eqdrd52	62	14	systems	system	NNS
cord-048322-5eqdrd52	62	15	have	have	VBP
cord-048322-5eqdrd52	62	16	emerged	emerge	VBN
cord-048322-5eqdrd52	62	17	as	as	IN
cord-048322-5eqdrd52	62	18	a	a	DT
cord-048322-5eqdrd52	62	19	promising	promising	JJ
cord-048322-5eqdrd52	62	20	alternative	alternative	NN
cord-048322-5eqdrd52	62	21	for	for	IN
cord-048322-5eqdrd52	62	22	gene	gene	NN
cord-048322-5eqdrd52	62	23	delivery	delivery	NN
cord-048322-5eqdrd52	62	24	.	.	.
cord-048322-5eqdrd52	63	1	Main	main	JJ
cord-048322-5eqdrd52	63	2	requirements	requirement	NNS
cord-048322-5eqdrd52	63	3	are	be	VBP
cord-048322-5eqdrd52	63	4	the	the	DT
cord-048322-5eqdrd52	63	5	protection	protection	NN
cord-048322-5eqdrd52	63	6	of	of	IN
cord-048322-5eqdrd52	63	7	their	-PRON-	PRP$
cord-048322-5eqdrd52	63	8	nucleic	nucleic	JJ
cord-048322-5eqdrd52	63	9	acid	acid	NN
cord-048322-5eqdrd52	63	10	"	"	``
cord-048322-5eqdrd52	63	11	load	load	NN
cord-048322-5eqdrd52	63	12	"	"	''
cord-048322-5eqdrd52	63	13	as	as	RB
cord-048322-5eqdrd52	63	14	well	well	RB
cord-048322-5eqdrd52	63	15	as	as	IN
cord-048322-5eqdrd52	63	16	their	-PRON-	PRP$
cord-048322-5eqdrd52	63	17	efficient	efficient	JJ
cord-048322-5eqdrd52	63	18	uptake	uptake	NN
cord-048322-5eqdrd52	63	19	into	into	IN
cord-048322-5eqdrd52	63	20	the	the	DT
cord-048322-5eqdrd52	63	21	target	target	NN
cord-048322-5eqdrd52	63	22	cells	cell	NNS
cord-048322-5eqdrd52	63	23	with	with	IN
cord-048322-5eqdrd52	63	24	subsequent	subsequent	JJ
cord-048322-5eqdrd52	63	25	release	release	NN
cord-048322-5eqdrd52	63	26	of	of	IN
cord-048322-5eqdrd52	63	27	the	the	DT
cord-048322-5eqdrd52	63	28	DNA	DNA	NNP
cord-048322-5eqdrd52	63	29	or	or	CC
cord-048322-5eqdrd52	63	30	RNA	RNA	NNP
cord-048322-5eqdrd52	63	31	molecules	molecule	NNS
cord-048322-5eqdrd52	63	32	and	and	CC
cord-048322-5eqdrd52	63	33	,	,	,
cord-048322-5eqdrd52	63	34	if	if	IN
cord-048322-5eqdrd52	63	35	necessary	necessary	JJ
cord-048322-5eqdrd52	63	36	,	,	,
cord-048322-5eqdrd52	63	37	their	-PRON-	PRP$
cord-048322-5eqdrd52	63	38	transfer	transfer	NN
cord-048322-5eqdrd52	63	39	into	into	IN
cord-048322-5eqdrd52	63	40	the	the	DT
cord-048322-5eqdrd52	63	41	nucleus	nucleus	NN
cord-048322-5eqdrd52	63	42	.	.	.
cord-048322-5eqdrd52	64	1	Several	several	JJ
cord-048322-5eqdrd52	64	2	strategies	strategy	NNS
cord-048322-5eqdrd52	64	3	can	can	MD
cord-048322-5eqdrd52	64	4	be	be	VB
cord-048322-5eqdrd52	64	5	distinguished	distinguish	VBN
cord-048322-5eqdrd52	64	6	,	,	,
cord-048322-5eqdrd52	64	7	mainly	mainly	RB
cord-048322-5eqdrd52	64	8	lipofection	lipofection	NN
cord-048322-5eqdrd52	64	9	and	and	CC
cord-048322-5eqdrd52	64	10	polyfection	polyfection	NN
cord-048322-5eqdrd52	64	11	relying	rely	VBG
cord-048322-5eqdrd52	64	12	on	on	IN
cord-048322-5eqdrd52	64	13	cationic	cationic	JJ
cord-048322-5eqdrd52	64	14	lipids	lipid	NNS
cord-048322-5eqdrd52	64	15	or	or	CC
cord-048322-5eqdrd52	64	16	polymers	polymer	NNS
cord-048322-5eqdrd52	64	17	,	,	,
cord-048322-5eqdrd52	64	18	respectively	respectively	RB
cord-048322-5eqdrd52	64	19	(	(	-LRB-
cord-048322-5eqdrd52	64	20	see	see	UH
cord-048322-5eqdrd52	64	21	,	,	,
cord-048322-5eqdrd52	64	22	eg	eg	XX
cord-048322-5eqdrd52	64	23	,	,	,
cord-048322-5eqdrd52	64	24	[	[	-LRB-
cord-048322-5eqdrd52	64	25	41	41	CD
cord-048322-5eqdrd52	64	26	]	]	-RRB-
cord-048322-5eqdrd52	64	27	[	[	-LRB-
cord-048322-5eqdrd52	64	28	42	42	CD
cord-048322-5eqdrd52	64	29	]	]	-RRB-
cord-048322-5eqdrd52	64	30	[	[	-LRB-
cord-048322-5eqdrd52	64	31	43	43	CD
cord-048322-5eqdrd52	64	32	]	]	-RRB-
cord-048322-5eqdrd52	64	33	)	)	-RRB-
cord-048322-5eqdrd52	64	34	.	.	.
cord-048322-5eqdrd52	65	1	The	the	DT
cord-048322-5eqdrd52	65	2	efficient	efficient	JJ
cord-048322-5eqdrd52	65	3	protection	protection	NN
cord-048322-5eqdrd52	65	4	against	against	IN
cord-048322-5eqdrd52	65	5	enzymatic	enzymatic	JJ
cord-048322-5eqdrd52	65	6	or	or	CC
cord-048322-5eqdrd52	65	7	nonenzymatic	nonenzymatic	JJ
cord-048322-5eqdrd52	65	8	degradation	degradation	NN
cord-048322-5eqdrd52	65	9	is	be	VBZ
cord-048322-5eqdrd52	65	10	particularly	particularly	RB
cord-048322-5eqdrd52	65	11	important	important	JJ
cord-048322-5eqdrd52	65	12	for	for	IN
cord-048322-5eqdrd52	65	13	RNA	RNA	NNP
cord-048322-5eqdrd52	65	14	molecules	molecule	NNS
cord-048322-5eqdrd52	65	15	including	include	VBG
cord-048322-5eqdrd52	65	16	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	65	17	.	.	.
cord-048322-5eqdrd52	66	1	In	in	IN
cord-048322-5eqdrd52	66	2	fact	fact	NN
cord-048322-5eqdrd52	66	3	,	,	,
cord-048322-5eqdrd52	66	4	while	while	IN
cord-048322-5eqdrd52	66	5	the	the	DT
cord-048322-5eqdrd52	66	6	therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	66	7	potential	potential	NN
cord-048322-5eqdrd52	66	8	of	of	IN
cord-048322-5eqdrd52	66	9	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	66	10	for	for	IN
cord-048322-5eqdrd52	66	11	the	the	DT
cord-048322-5eqdrd52	66	12	treatment	treatment	NN
cord-048322-5eqdrd52	66	13	of	of	IN
cord-048322-5eqdrd52	66	14	various	various	JJ
cord-048322-5eqdrd52	66	15	diseases	disease	NNS
cord-048322-5eqdrd52	66	16	is	be	VBZ
cord-048322-5eqdrd52	66	17	in	in	IN
cord-048322-5eqdrd52	66	18	principle	principle	NN
cord-048322-5eqdrd52	66	19	very	very	RB
cord-048322-5eqdrd52	66	20	promising	promising	JJ
cord-048322-5eqdrd52	66	21	,	,	,
cord-048322-5eqdrd52	66	22	limitations	limitation	NNS
cord-048322-5eqdrd52	66	23	of	of	IN
cord-048322-5eqdrd52	66	24	transfer	transfer	NN
cord-048322-5eqdrd52	66	25	vectors	vector	NNS
cord-048322-5eqdrd52	66	26	may	may	MD
cord-048322-5eqdrd52	66	27	turn	turn	VB
cord-048322-5eqdrd52	66	28	out	out	RP
cord-048322-5eqdrd52	66	29	to	to	TO
cord-048322-5eqdrd52	66	30	be	be	VB
cord-048322-5eqdrd52	66	31	rate	rate	NN
cord-048322-5eqdrd52	66	32	-	-	HYPH
cord-048322-5eqdrd52	66	33	limiting	limit	VBG
cord-048322-5eqdrd52	66	34	in	in	IN
cord-048322-5eqdrd52	66	35	the	the	DT
cord-048322-5eqdrd52	66	36	development	development	NN
cord-048322-5eqdrd52	66	37	of	of	IN
cord-048322-5eqdrd52	66	38	RNAi	RNAi	NNP
cord-048322-5eqdrd52	66	39	-	-	HYPH
cord-048322-5eqdrd52	66	40	based	base	VBN
cord-048322-5eqdrd52	66	41	therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	66	42	strategies	strategy	NNS
cord-048322-5eqdrd52	66	43	.	.	.
cord-048322-5eqdrd52	67	1	One	one	CD
cord-048322-5eqdrd52	67	2	approach	approach	NN
cord-048322-5eqdrd52	67	3	to	to	TO
cord-048322-5eqdrd52	67	4	solve	solve	VB
cord-048322-5eqdrd52	67	5	this	this	DT
cord-048322-5eqdrd52	67	6	problem	problem	NN
cord-048322-5eqdrd52	67	7	is	be	VBZ
cord-048322-5eqdrd52	67	8	the	the	DT
cord-048322-5eqdrd52	67	9	use	use	NN
cord-048322-5eqdrd52	67	10	of	of	IN
cord-048322-5eqdrd52	67	11	DNA	dna	NN
cord-048322-5eqdrd52	67	12	expression	expression	NN
cord-048322-5eqdrd52	67	13	plasmids	plasmid	NNS
cord-048322-5eqdrd52	67	14	which	which	WDT
cord-048322-5eqdrd52	67	15	encode	encode	VBP
cord-048322-5eqdrd52	67	16	palindromic	palindromic	JJ
cord-048322-5eqdrd52	67	17	hairpin	hairpin	JJ
cord-048322-5eqdrd52	67	18	loops	loop	NNS
cord-048322-5eqdrd52	67	19	with	with	IN
cord-048322-5eqdrd52	67	20	the	the	DT
cord-048322-5eqdrd52	67	21	desired	desire	VBN
cord-048322-5eqdrd52	67	22	sequence	sequence	NN
cord-048322-5eqdrd52	67	23	.	.	.
cord-048322-5eqdrd52	68	1	Upon	upon	IN
cord-048322-5eqdrd52	68	2	transcription	transcription	NN
cord-048322-5eqdrd52	68	3	and	and	CC
cord-048322-5eqdrd52	68	4	folding	folding	NN
cord-048322-5eqdrd52	68	5	of	of	IN
cord-048322-5eqdrd52	68	6	the	the	DT
cord-048322-5eqdrd52	68	7	RNA	RNA	NNP
cord-048322-5eqdrd52	68	8	,	,	,
cord-048322-5eqdrd52	68	9	the	the	DT
cord-048322-5eqdrd52	68	10	doublestranded	doublestranded	JJ
cord-048322-5eqdrd52	68	11	short	short	JJ
cord-048322-5eqdrd52	68	12	hairpin	hairpin	NN
cord-048322-5eqdrd52	68	13	RNAs	rna	NNS
cord-048322-5eqdrd52	68	14	(	(	-LRB-
cord-048322-5eqdrd52	68	15	shRNAs	shRNAs	NNP
cord-048322-5eqdrd52	68	16	)	)	-RRB-
cord-048322-5eqdrd52	68	17	are	be	VBP
cord-048322-5eqdrd52	68	18	recognized	recognize	VBN
cord-048322-5eqdrd52	68	19	by	by	IN
cord-048322-5eqdrd52	68	20	Dicer	Dicer	NNP
cord-048322-5eqdrd52	68	21	and	and	CC
cord-048322-5eqdrd52	68	22	cleaved	cleave	VBD
cord-048322-5eqdrd52	68	23	into	into	IN
cord-048322-5eqdrd52	68	24	the	the	DT
cord-048322-5eqdrd52	68	25	desired	desire	VBN
cord-048322-5eqdrd52	68	26	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	68	27	.	.	.
cord-048322-5eqdrd52	69	1	Additionally	additionally	RB
cord-048322-5eqdrd52	69	2	,	,	,
cord-048322-5eqdrd52	69	3	an	an	DT
cord-048322-5eqdrd52	69	4	in	in	FW
cord-048322-5eqdrd52	69	5	vitro	vitro	FW
cord-048322-5eqdrd52	69	6	method	method	NN
cord-048322-5eqdrd52	69	7	has	have	VBZ
cord-048322-5eqdrd52	69	8	been	be	VBN
cord-048322-5eqdrd52	69	9	described	describe	VBN
cord-048322-5eqdrd52	69	10	recently	recently	RB
cord-048322-5eqdrd52	69	11	which	which	WDT
cord-048322-5eqdrd52	69	12	is	be	VBZ
cord-048322-5eqdrd52	69	13	based	base	VBN
cord-048322-5eqdrd52	69	14	on	on	IN
cord-048322-5eqdrd52	69	15	the	the	DT
cord-048322-5eqdrd52	69	16	expression	expression	NN
cord-048322-5eqdrd52	69	17	of	of	IN
cord-048322-5eqdrd52	69	18	shRNAs	shRNAs	NNP
cord-048322-5eqdrd52	69	19	in	in	IN
cord-048322-5eqdrd52	69	20	E	e	NN
cord-048322-5eqdrd52	69	21	coli	coli	NNS
cord-048322-5eqdrd52	69	22	and	and	CC
cord-048322-5eqdrd52	69	23	their	-PRON-	PRP$
cord-048322-5eqdrd52	69	24	delivery	delivery	NN
cord-048322-5eqdrd52	69	25	via	via	IN
cord-048322-5eqdrd52	69	26	bacterial	bacterial	JJ
cord-048322-5eqdrd52	69	27	invasion	invasion	NN
cord-048322-5eqdrd52	69	28	[	[	-LRB-
cord-048322-5eqdrd52	69	29	44	44	CD
cord-048322-5eqdrd52	69	30	]	]	-RRB-
cord-048322-5eqdrd52	69	31	.	.	.
cord-048322-5eqdrd52	70	1	While	while	IN
cord-048322-5eqdrd52	70	2	all	all	PDT
cord-048322-5eqdrd52	70	3	these	these	DT
cord-048322-5eqdrd52	70	4	different	different	JJ
cord-048322-5eqdrd52	70	5	DNAbased	dnabase	VBN
cord-048322-5eqdrd52	70	6	systems	system	NNS
cord-048322-5eqdrd52	70	7	offer	offer	VBP
cord-048322-5eqdrd52	70	8	the	the	DT
cord-048322-5eqdrd52	70	9	advantage	advantage	NN
cord-048322-5eqdrd52	70	10	of	of	IN
cord-048322-5eqdrd52	70	11	siRNA	siRNA	NNP
cord-048322-5eqdrd52	70	12	expression	expression	NN
cord-048322-5eqdrd52	70	13	with	with	IN
cord-048322-5eqdrd52	70	14	a	a	DT
cord-048322-5eqdrd52	70	15	longer	long	JJR
cord-048322-5eqdrd52	70	16	duration	duration	NN
cord-048322-5eqdrd52	70	17	and	and	CC
cord-048322-5eqdrd52	70	18	a	a	DT
cord-048322-5eqdrd52	70	19	probably	probably	RB
cord-048322-5eqdrd52	70	20	higher	high	JJR
cord-048322-5eqdrd52	70	21	level	level	NN
cord-048322-5eqdrd52	70	22	of	of	IN
cord-048322-5eqdrd52	70	23	gene	gene	NN
cord-048322-5eqdrd52	70	24	silencing	silencing	NN
cord-048322-5eqdrd52	70	25	,	,	,
cord-048322-5eqdrd52	70	26	they	-PRON-	PRP
cord-048322-5eqdrd52	70	27	still	still	RB
cord-048322-5eqdrd52	70	28	rely	rely	VBP
cord-048322-5eqdrd52	70	29	on	on	IN
cord-048322-5eqdrd52	70	30	(	(	-LRB-
cord-048322-5eqdrd52	70	31	viral	viral	JJ
cord-048322-5eqdrd52	70	32	or	or	CC
cord-048322-5eqdrd52	70	33	nonviral	nonviral	JJ
cord-048322-5eqdrd52	70	34	)	)	-RRB-
cord-048322-5eqdrd52	70	35	delivery	delivery	NN
cord-048322-5eqdrd52	70	36	of	of	IN
cord-048322-5eqdrd52	70	37	DNA	dna	NN
cord-048322-5eqdrd52	70	38	molecules	molecule	NNS
cord-048322-5eqdrd52	70	39	and	and	CC
cord-048322-5eqdrd52	70	40	again	again	RB
cord-048322-5eqdrd52	70	41	raise	raise	VB
cord-048322-5eqdrd52	70	42	safety	safety	NN
cord-048322-5eqdrd52	70	43	issues	issue	NNS
cord-048322-5eqdrd52	70	44	in	in	IN
cord-048322-5eqdrd52	70	45	vivo	vivo	NN
cord-048322-5eqdrd52	70	46	.	.	.
cord-048322-5eqdrd52	71	1	Hence	hence	RB
cord-048322-5eqdrd52	71	2	,	,	,
cord-048322-5eqdrd52	71	3	the	the	DT
cord-048322-5eqdrd52	71	4	direct	direct	JJ
cord-048322-5eqdrd52	71	5	delivery	delivery	NN
cord-048322-5eqdrd52	71	6	of	of	IN
cord-048322-5eqdrd52	71	7	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	71	8	molecules	molecule	NNS
cord-048322-5eqdrd52	71	9	,	,	,
cord-048322-5eqdrd52	71	10	derived	derive	VBN
cord-048322-5eqdrd52	71	11	from	from	IN
cord-048322-5eqdrd52	71	12	in	in	IN
cord-048322-5eqdrd52	71	13	vitro	vitro	FW
cord-048322-5eqdrd52	71	14	transcription	transcription	NN
cord-048322-5eqdrd52	71	15	or	or	CC
cord-048322-5eqdrd52	71	16	chemically	chemically	RB
cord-048322-5eqdrd52	71	17	synthesized	synthesize	VBN
cord-048322-5eqdrd52	71	18	,	,	,
cord-048322-5eqdrd52	71	19	offers	offer	VBZ
cord-048322-5eqdrd52	71	20	advantages	advantage	NNS
cord-048322-5eqdrd52	71	21	over	over	IN
cord-048322-5eqdrd52	71	22	DNA	dna	NN
cord-048322-5eqdrd52	71	23	-	-	HYPH
cord-048322-5eqdrd52	71	24	based	base	VBN
cord-048322-5eqdrd52	71	25	strategies	strategy	NNS
cord-048322-5eqdrd52	71	26	and	and	CC
cord-048322-5eqdrd52	71	27	may	may	MD
cord-048322-5eqdrd52	71	28	be	be	VB
cord-048322-5eqdrd52	71	29	preferable	preferable	JJ
cord-048322-5eqdrd52	71	30	for	for	IN
cord-048322-5eqdrd52	71	31	in	in	IN
cord-048322-5eqdrd52	71	32	vivo	vivo	FW
cord-048322-5eqdrd52	71	33	therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	71	34	use	use	NN
cord-048322-5eqdrd52	71	35	.	.	.
cord-048322-5eqdrd52	72	1	In	in	IN
cord-048322-5eqdrd52	72	2	the	the	DT
cord-048322-5eqdrd52	72	3	last	last	JJ
cord-048322-5eqdrd52	72	4	years	year	NNS
cord-048322-5eqdrd52	72	5	,	,	,
cord-048322-5eqdrd52	72	6	a	a	DT
cord-048322-5eqdrd52	72	7	large	large	JJ
cord-048322-5eqdrd52	72	8	body	body	NN
cord-048322-5eqdrd52	72	9	of	of	IN
cord-048322-5eqdrd52	72	10	studies	study	NNS
cord-048322-5eqdrd52	72	11	has	have	VBZ
cord-048322-5eqdrd52	72	12	been	be	VBN
cord-048322-5eqdrd52	72	13	published	publish	VBN
cord-048322-5eqdrd52	72	14	which	which	WDT
cord-048322-5eqdrd52	72	15	describe	describe	VBP
cord-048322-5eqdrd52	72	16	different	different	JJ
cord-048322-5eqdrd52	72	17	strategies	strategy	NNS
cord-048322-5eqdrd52	72	18	for	for	IN
cord-048322-5eqdrd52	72	19	the	the	DT
cord-048322-5eqdrd52	72	20	systemic	systemic	JJ
cord-048322-5eqdrd52	72	21	or	or	CC
cord-048322-5eqdrd52	72	22	local	local	JJ
cord-048322-5eqdrd52	72	23	application	application	NN
cord-048322-5eqdrd52	72	24	of	of	IN
cord-048322-5eqdrd52	72	25	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	72	26	in	in	IN
cord-048322-5eqdrd52	72	27	vivo	vivo	NN
cord-048322-5eqdrd52	72	28	.	.	.
cord-048322-5eqdrd52	73	1	Tables	table	NNS
cord-048322-5eqdrd52	73	2	1	1	CD
cord-048322-5eqdrd52	73	3	-	-	SYM
cord-048322-5eqdrd52	73	4	3	3	CD
cord-048322-5eqdrd52	73	5	give	give	VBP
cord-048322-5eqdrd52	73	6	an	an	DT
cord-048322-5eqdrd52	73	7	overview	overview	NN
cord-048322-5eqdrd52	73	8	.	.	.
cord-048322-5eqdrd52	74	1	The	the	DT
cord-048322-5eqdrd52	74	2	probably	probably	RB
cord-048322-5eqdrd52	74	3	largest	large	JJS
cord-048322-5eqdrd52	74	4	number	number	NN
cord-048322-5eqdrd52	74	5	of	of	IN
cord-048322-5eqdrd52	74	6	papers	paper	NNS
cord-048322-5eqdrd52	74	7	focuses	focus	VBZ
cord-048322-5eqdrd52	74	8	the	the	DT
cord-048322-5eqdrd52	74	9	use	use	NN
cord-048322-5eqdrd52	74	10	of	of	IN
cord-048322-5eqdrd52	74	11	unmodified	unmodified	JJ
cord-048322-5eqdrd52	74	12	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	74	13	(	(	-LRB-
cord-048322-5eqdrd52	74	14	Table	Table	NNP
cord-048322-5eqdrd52	74	15	1	1	CD
cord-048322-5eqdrd52	74	16	)	)	-RRB-
cord-048322-5eqdrd52	74	17	whose	whose	WP$
cord-048322-5eqdrd52	74	18	administration	administration	NN
cord-048322-5eqdrd52	74	19	is	be	VBZ
cord-048322-5eqdrd52	74	20	often	often	RB
cord-048322-5eqdrd52	74	21	performed	perform	VBN
cord-048322-5eqdrd52	74	22	IV	IV	NNP
cord-048322-5eqdrd52	74	23	by	by	IN
cord-048322-5eqdrd52	74	24	hydrodynamic	hydrodynamic	JJ
cord-048322-5eqdrd52	74	25	transfection	transfection	NN
cord-048322-5eqdrd52	74	26	(	(	-LRB-
cord-048322-5eqdrd52	74	27	high	high	JJ
cord-048322-5eqdrd52	74	28	pressure	pressure	NN
cord-048322-5eqdrd52	74	29	tail	tail	NN
cord-048322-5eqdrd52	74	30	vein	vein	NN
cord-048322-5eqdrd52	74	31	injection	injection	NN
cord-048322-5eqdrd52	74	32	)	)	-RRB-
cord-048322-5eqdrd52	74	33	.	.	.
cord-048322-5eqdrd52	75	1	While	while	IN
cord-048322-5eqdrd52	75	2	this	this	DT
cord-048322-5eqdrd52	75	3	method	method	NN
cord-048322-5eqdrd52	75	4	is	be	VBZ
cord-048322-5eqdrd52	75	5	widely	widely	RB
cord-048322-5eqdrd52	75	6	used	use	VBN
cord-048322-5eqdrd52	75	7	and	and	CC
cord-048322-5eqdrd52	75	8	in	in	IN
cord-048322-5eqdrd52	75	9	some	some	DT
cord-048322-5eqdrd52	75	10	cases	case	NNS
cord-048322-5eqdrd52	75	11	led	lead	VBD
cord-048322-5eqdrd52	75	12	to	to	IN
cord-048322-5eqdrd52	75	13	efficient	efficient	JJ
cord-048322-5eqdrd52	75	14	target	target	NN
cord-048322-5eqdrd52	75	15	gene	gene	NN
cord-048322-5eqdrd52	75	16	inhibition	inhibition	NN
cord-048322-5eqdrd52	75	17	in	in	IN
cord-048322-5eqdrd52	75	18	the	the	DT
cord-048322-5eqdrd52	75	19	liver	liver	NN
cord-048322-5eqdrd52	75	20	and	and	CC
cord-048322-5eqdrd52	75	21	,	,	,
cord-048322-5eqdrd52	75	22	to	to	IN
cord-048322-5eqdrd52	75	23	a	a	DT
cord-048322-5eqdrd52	75	24	lesser	less	JJR
cord-048322-5eqdrd52	75	25	extent	extent	NN
cord-048322-5eqdrd52	75	26	,	,	,
cord-048322-5eqdrd52	75	27	in	in	IN
cord-048322-5eqdrd52	75	28	lung	lung	NN
cord-048322-5eqdrd52	75	29	,	,	,
cord-048322-5eqdrd52	75	30	spleen	spleen	NNS
cord-048322-5eqdrd52	75	31	,	,	,
cord-048322-5eqdrd52	75	32	pancreas	pancrea	NNS
cord-048322-5eqdrd52	75	33	,	,	,
cord-048322-5eqdrd52	75	34	and	and	CC
cord-048322-5eqdrd52	75	35	kidney	kidney	NN
cord-048322-5eqdrd52	75	36	,	,	,
cord-048322-5eqdrd52	75	37	it	-PRON-	PRP
cord-048322-5eqdrd52	75	38	may	may	MD
cord-048322-5eqdrd52	75	39	suffer	suffer	VB
cord-048322-5eqdrd52	75	40	from	from	IN
cord-048322-5eqdrd52	75	41	certain	certain	JJ
cord-048322-5eqdrd52	75	42	technical	technical	JJ
cord-048322-5eqdrd52	75	43	and	and	CC
cord-048322-5eqdrd52	75	44	practical	practical	JJ
cord-048322-5eqdrd52	75	45	limitations	limitation	NNS
cord-048322-5eqdrd52	75	46	at	at	IN
cord-048322-5eqdrd52	75	47	least	least	JJS
cord-048322-5eqdrd52	75	48	in	in	IN
cord-048322-5eqdrd52	75	49	a	a	DT
cord-048322-5eqdrd52	75	50	therapeutical	therapeutical	JJ
cord-048322-5eqdrd52	75	51	setting	setting	NN
cord-048322-5eqdrd52	75	52	since	since	IN
cord-048322-5eqdrd52	75	53	it	-PRON-	PRP
cord-048322-5eqdrd52	75	54	relies	rely	VBZ
cord-048322-5eqdrd52	75	55	on	on	IN
cord-048322-5eqdrd52	75	56	the	the	DT
cord-048322-5eqdrd52	75	57	rapid	rapid	JJ
cord-048322-5eqdrd52	75	58	IV	IV	NNP
cord-048322-5eqdrd52	75	59	injection	injection	NN
cord-048322-5eqdrd52	75	60	of	of	IN
cord-048322-5eqdrd52	75	61	a	a	DT
cord-048322-5eqdrd52	75	62	comparably	comparably	RB
cord-048322-5eqdrd52	75	63	large	large	JJ
cord-048322-5eqdrd52	75	64	volume	volume	NN
cord-048322-5eqdrd52	75	65	(	(	-LRB-
cord-048322-5eqdrd52	75	66	>	>	XX
cord-048322-5eqdrd52	75	67	=	=	SYM
cord-048322-5eqdrd52	75	68	1	1	CD
cord-048322-5eqdrd52	75	69	ml	ml	NN
cord-048322-5eqdrd52	75	70	/	/	SYM
cord-048322-5eqdrd52	75	71	mouse	mouse	NN
cord-048322-5eqdrd52	75	72	/	/	SYM
cord-048322-5eqdrd52	75	73	injection	injection	NN
cord-048322-5eqdrd52	75	74	,	,	,
cord-048322-5eqdrd52	75	75	in	in	IN
cord-048322-5eqdrd52	75	76	theory	theory	NN
cord-048322-5eqdrd52	75	77	equivalent	equivalent	JJ
cord-048322-5eqdrd52	75	78	to	to	IN
cord-048322-5eqdrd52	75	79	a	a	DT
cord-048322-5eqdrd52	75	80	∼	∼	NN
cord-048322-5eqdrd52	75	81	3	3	CD
cord-048322-5eqdrd52	75	82	l	l	NN
cord-048322-5eqdrd52	75	83	IV	IV	NNP
cord-048322-5eqdrd52	75	84	bolus	bolus	NN
cord-048322-5eqdrd52	75	85	injection	injection	NN
cord-048322-5eqdrd52	75	86	in	in	IN
cord-048322-5eqdrd52	75	87	man	man	NN
cord-048322-5eqdrd52	75	88	)	)	-RRB-
cord-048322-5eqdrd52	75	89	.	.	.
cord-048322-5eqdrd52	76	1	Alternative	alternative	JJ
cord-048322-5eqdrd52	76	2	strategies	strategy	NNS
cord-048322-5eqdrd52	76	3	for	for	IN
cord-048322-5eqdrd52	76	4	the	the	DT
cord-048322-5eqdrd52	76	5	application	application	NN
cord-048322-5eqdrd52	76	6	of	of	IN
cord-048322-5eqdrd52	76	7	naked	naked	JJ
cord-048322-5eqdrd52	76	8	siRNAs	sirna	NNS
cord-048322-5eqdrd52	76	9	include	include	VBP
cord-048322-5eqdrd52	76	10	various	various	JJ
cord-048322-5eqdrd52	76	11	delivery	delivery	NN
cord-048322-5eqdrd52	76	12	routes	route	NNS
cord-048322-5eqdrd52	76	13	which	which	WDT
cord-048322-5eqdrd52	76	14	,	,	,
cord-048322-5eqdrd52	76	15	however	however	RB
cord-048322-5eqdrd52	76	16	,	,	,
cord-048322-5eqdrd52	76	17	often	often	RB
cord-048322-5eqdrd52	76	18	provide	provide	VBP
cord-048322-5eqdrd52	76	19	an	an	DT
cord-048322-5eqdrd52	76	20	only	only	JJ
cord-048322-5eqdrd52	76	21	local	local	JJ
cord-048322-5eqdrd52	76	22	administration	administration	NN
cord-048322-5eqdrd52	76	23	or	or	CC
cord-048322-5eqdrd52	76	24	rely	rely	VB
cord-048322-5eqdrd52	76	25	on	on	IN
cord-048322-5eqdrd52	76	26	an	an	DT
cord-048322-5eqdrd52	76	27	administration	administration	NN
cord-048322-5eqdrd52	76	28	at	at	IN
cord-048322-5eqdrd52	76	29	least	least	JJS
cord-048322-5eqdrd52	76	30	close	close	RB
cord-048322-5eqdrd52	76	31	to	to	IN
cord-048322-5eqdrd52	76	32	the	the	DT
cord-048322-5eqdrd52	76	33	target	target	NN
cord-048322-5eqdrd52	76	34	tissue	tissue	NN
cord-048322-5eqdrd52	76	35	or	or	CC
cord-048322-5eqdrd52	76	36	target	target	NN
cord-048322-5eqdrd52	76	37	organ	organ	NN
cord-048322-5eqdrd52	76	38	,	,	,
cord-048322-5eqdrd52	76	39	thus	thus	RB
cord-048322-5eqdrd52	76	40	restricting	restrict	VBG
cord-048322-5eqdrd52	76	41	the	the	DT
cord-048322-5eqdrd52	76	42	number	number	NN
cord-048322-5eqdrd52	76	43	of	of	IN
cord-048322-5eqdrd52	76	44	target	target	NN
cord-048322-5eqdrd52	76	45	organs	organ	NNS
cord-048322-5eqdrd52	76	46	which	which	WDT
cord-048322-5eqdrd52	76	47	may	may	MD
cord-048322-5eqdrd52	76	48	not	not	RB
cord-048322-5eqdrd52	76	49	be	be	VB
cord-048322-5eqdrd52	76	50	relevant	relevant	JJ
cord-048322-5eqdrd52	76	51	for	for	IN
cord-048322-5eqdrd52	76	52	certain	certain	JJ
cord-048322-5eqdrd52	76	53	diseases	disease	NNS
cord-048322-5eqdrd52	76	54	.	.	.
cord-048322-5eqdrd52	77	1	It	-PRON-	PRP
cord-048322-5eqdrd52	77	2	should	should	MD
cord-048322-5eqdrd52	77	3	also	also	RB
cord-048322-5eqdrd52	77	4	be	be	VB
cord-048322-5eqdrd52	77	5	noted	note	VBN
cord-048322-5eqdrd52	77	6	that	that	IN
cord-048322-5eqdrd52	77	7	several	several	JJ
cord-048322-5eqdrd52	77	8	studies	study	NNS
cord-048322-5eqdrd52	77	9	described	describe	VBN
cord-048322-5eqdrd52	77	10	here	here	RB
cord-048322-5eqdrd52	77	11	and	and	CC
cord-048322-5eqdrd52	77	12	below	below	IN
cord-048322-5eqdrd52	77	13	use	use	VBP
cord-048322-5eqdrd52	77	14	rather	rather	RB
cord-048322-5eqdrd52	77	15	large	large	JJ
cord-048322-5eqdrd52	77	16	amounts	amount	NNS
cord-048322-5eqdrd52	77	17	of	of	IN
cord-048322-5eqdrd52	77	18	siRNAs	sirnas	NN
cord-048322-5eqdrd52	77	19	and	and	CC
cord-048322-5eqdrd52	77	20	that	that	IN
cord-048322-5eqdrd52	77	21	upon	upon	IN
cord-048322-5eqdrd52	77	22	intravenous	intravenous	JJ
cord-048322-5eqdrd52	77	23	injection	injection	NN
cord-048322-5eqdrd52	77	24	of	of	IN
cord-048322-5eqdrd52	77	25	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	77	26	the	the	DT
cord-048322-5eqdrd52	77	27	liver	liver	NN
cord-048322-5eqdrd52	77	28	is	be	VBZ
cord-048322-5eqdrd52	77	29	the	the	DT
cord-048322-5eqdrd52	77	30	primary	primary	JJ
cord-048322-5eqdrd52	77	31	site	site	NN
cord-048322-5eqdrd52	77	32	of	of	IN
cord-048322-5eqdrd52	77	33	siRNA	siRNA	NNP
cord-048322-5eqdrd52	77	34	uptake	uptake	NN
cord-048322-5eqdrd52	77	35	.	.	.
cord-048322-5eqdrd52	78	1	As	as	IN
cord-048322-5eqdrd52	78	2	an	an	DT
cord-048322-5eqdrd52	78	3	alternative	alternative	JJ
cord-048322-5eqdrd52	78	4	approach	approach	NN
cord-048322-5eqdrd52	78	5	for	for	IN
cord-048322-5eqdrd52	78	6	the	the	DT
cord-048322-5eqdrd52	78	7	application	application	NN
cord-048322-5eqdrd52	78	8	of	of	IN
cord-048322-5eqdrd52	78	9	siR	siR	NNP
cord-048322-5eqdrd52	78	10	-	-	HYPH
cord-048322-5eqdrd52	78	11	NAs	NAs	NNPS
cord-048322-5eqdrd52	78	12	in	in	IN
cord-048322-5eqdrd52	78	13	vivo	vivo	NNP
cord-048322-5eqdrd52	78	14	,	,	,
cord-048322-5eqdrd52	78	15	their	-PRON-	PRP$
cord-048322-5eqdrd52	78	16	delivery	delivery	NN
cord-048322-5eqdrd52	78	17	by	by	IN
cord-048322-5eqdrd52	78	18	liposomes	liposome	NNS
cord-048322-5eqdrd52	78	19	/	/	SYM
cord-048322-5eqdrd52	78	20	cationic	cationic	JJ
cord-048322-5eqdrd52	78	21	lipids	lipid	NNS
cord-048322-5eqdrd52	78	22	has	have	VBZ
cord-048322-5eqdrd52	78	23	been	be	VBN
cord-048322-5eqdrd52	78	24	described	describe	VBN
cord-048322-5eqdrd52	78	25	.	.	.
cord-048322-5eqdrd52	79	1	For	for	IN
cord-048322-5eqdrd52	79	2	liposome	liposome	NN
cord-048322-5eqdrd52	79	3	-	-	HYPH
cord-048322-5eqdrd52	79	4	based	base	VBN
cord-048322-5eqdrd52	79	5	siRNA	siRNA	NNP
cord-048322-5eqdrd52	79	6	formulations	formulation	NNS
cord-048322-5eqdrd52	79	7	,	,	,
cord-048322-5eqdrd52	79	8	a	a	DT
cord-048322-5eqdrd52	79	9	wide	wide	JJ
cord-048322-5eqdrd52	79	10	variety	variety	NN
cord-048322-5eqdrd52	79	11	of	of	IN
cord-048322-5eqdrd52	79	12	modes	mode	NNS
cord-048322-5eqdrd52	79	13	of	of	IN
cord-048322-5eqdrd52	79	14	application	application	NN
cord-048322-5eqdrd52	79	15	allowing	allow	VBG
cord-048322-5eqdrd52	79	16	local	local	JJ
cord-048322-5eqdrd52	79	17	or	or	CC
cord-048322-5eqdrd52	79	18	systemic	systemic	JJ
cord-048322-5eqdrd52	79	19	delivery	delivery	NN
cord-048322-5eqdrd52	79	20	has	have	VBZ
cord-048322-5eqdrd52	79	21	been	be	VBN
cord-048322-5eqdrd52	79	22	used	use	VBN
cord-048322-5eqdrd52	79	23	(	(	-LRB-
cord-048322-5eqdrd52	79	24	Table	table	NN
cord-048322-5eqdrd52	79	25	2	2	CD
cord-048322-5eqdrd52	79	26	)	)	-RRB-
cord-048322-5eqdrd52	79	27	.	.	.
cord-048322-5eqdrd52	80	1	Finally	finally	RB
cord-048322-5eqdrd52	80	2	,	,	,
cord-048322-5eqdrd52	80	3	several	several	JJ
cord-048322-5eqdrd52	80	4	other	other	JJ
cord-048322-5eqdrd52	80	5	strategies	strategy	NNS
cord-048322-5eqdrd52	80	6	for	for	IN
cord-048322-5eqdrd52	80	7	local	local	JJ
cord-048322-5eqdrd52	80	8	or	or	CC
cord-048322-5eqdrd52	80	9	systemic	systemic	JJ
cord-048322-5eqdrd52	80	10	siRNA	siRNA	NNP
cord-048322-5eqdrd52	80	11	administration	administration	NN
cord-048322-5eqdrd52	80	12	have	have	VBP
cord-048322-5eqdrd52	80	13	been	be	VBN
cord-048322-5eqdrd52	80	14	explored	explore	VBN
cord-048322-5eqdrd52	80	15	,	,	,
cord-048322-5eqdrd52	80	16	including	include	VBG
cord-048322-5eqdrd52	80	17	chemical	chemical	JJ
cord-048322-5eqdrd52	80	18	modifications	modification	NNS
cord-048322-5eqdrd52	80	19	of	of	IN
cord-048322-5eqdrd52	80	20	siRNA	siRNA	NNP
cord-048322-5eqdrd52	80	21	molecules	molecule	NNS
cord-048322-5eqdrd52	80	22	,	,	,
cord-048322-5eqdrd52	80	23	electropulsation	electropulsation	NN
cord-048322-5eqdrd52	80	24	,	,	,
cord-048322-5eqdrd52	80	25	polyamine	polyamine	NN
cord-048322-5eqdrd52	80	26	,	,	,
cord-048322-5eqdrd52	80	27	or	or	CC
cord-048322-5eqdrd52	80	28	other	other	JJ
cord-048322-5eqdrd52	80	29	basic	basic	JJ
cord-048322-5eqdrd52	80	30	complexes	complex	NNS
cord-048322-5eqdrd52	80	31	,	,	,
cord-048322-5eqdrd52	80	32	atelocollagen	atelocollagen	NNP
cord-048322-5eqdrd52	80	33	,	,	,
cord-048322-5eqdrd52	80	34	virosomes	virosomes	NNP
cord-048322-5eqdrd52	80	35	,	,	,
cord-048322-5eqdrd52	80	36	and	and	CC
cord-048322-5eqdrd52	80	37	certain	certain	JJ
cord-048322-5eqdrd52	80	38	protein	protein	NN
cord-048322-5eqdrd52	80	39	preparations	preparation	NNS
cord-048322-5eqdrd52	80	40	(	(	-LRB-
cord-048322-5eqdrd52	80	41	Table	Table	NNP
cord-048322-5eqdrd52	80	42	3	3	CD
cord-048322-5eqdrd52	80	43	)	)	-RRB-
cord-048322-5eqdrd52	80	44	.	.	.
cord-048322-5eqdrd52	81	1	An	an	DT
cord-048322-5eqdrd52	81	2	alternative	alternative	JJ
cord-048322-5eqdrd52	81	3	approach	approach	NN
cord-048322-5eqdrd52	81	4	relies	rely	VBZ
cord-048322-5eqdrd52	81	5	on	on	IN
cord-048322-5eqdrd52	81	6	the	the	DT
cord-048322-5eqdrd52	81	7	complexation	complexation	NN
cord-048322-5eqdrd52	81	8	of	of	IN
cord-048322-5eqdrd52	81	9	unmodified	unmodified	JJ
cord-048322-5eqdrd52	81	10	siRNA	siRNA	NNP
cord-048322-5eqdrd52	81	11	molecules	molecule	NNS
cord-048322-5eqdrd52	81	12	with	with	IN
cord-048322-5eqdrd52	81	13	a	a	DT
cord-048322-5eqdrd52	81	14	cationic	cationic	JJ
cord-048322-5eqdrd52	81	15	polymer	polymer	NN
cord-048322-5eqdrd52	81	16	,	,	,
cord-048322-5eqdrd52	81	17	polyethylenimine	polyethylenimine	NNP
cord-048322-5eqdrd52	81	18	(	(	-LRB-
cord-048322-5eqdrd52	81	19	PEI	PEI	NNP
cord-048322-5eqdrd52	81	20	)	)	-RRB-
cord-048322-5eqdrd52	81	21	.	.	.
cord-048322-5eqdrd52	82	1	Polyethylenimines	polyethylenimine	NNS
cord-048322-5eqdrd52	82	2	(	(	-LRB-
cord-048322-5eqdrd52	82	3	PEIs	PEIs	NNPS
cord-048322-5eqdrd52	82	4	)	)	-RRB-
cord-048322-5eqdrd52	82	5	are	be	VBP
cord-048322-5eqdrd52	82	6	synthetic	synthetic	JJ
cord-048322-5eqdrd52	82	7	polymers	polymer	NNS
cord-048322-5eqdrd52	82	8	available	available	JJ
cord-048322-5eqdrd52	82	9	in	in	IN
cord-048322-5eqdrd52	82	10	branched	branched	JJ
cord-048322-5eqdrd52	82	11	or	or	CC
cord-048322-5eqdrd52	82	12	linear	linear	JJ
cord-048322-5eqdrd52	82	13	forms	form	NNS
cord-048322-5eqdrd52	82	14	(	(	-LRB-
cord-048322-5eqdrd52	82	15	Figure	figure	NN
cord-048322-5eqdrd52	82	16	2	2	CD
cord-048322-5eqdrd52	82	17	,	,	,
cord-048322-5eqdrd52	82	18	upper	upper	JJ
cord-048322-5eqdrd52	82	19	panels	panel	NNS
cord-048322-5eqdrd52	82	20	)	)	-RRB-
cord-048322-5eqdrd52	82	21	and	and	CC
cord-048322-5eqdrd52	82	22	in	in	IN
cord-048322-5eqdrd52	82	23	a	a	DT
cord-048322-5eqdrd52	82	24	broad	broad	JJ
cord-048322-5eqdrd52	82	25	range	range	NN
cord-048322-5eqdrd52	82	26	of	of	IN
cord-048322-5eqdrd52	82	27	molecular	molecular	JJ
cord-048322-5eqdrd52	82	28	weights	weight	NNS
cord-048322-5eqdrd52	82	29	from	from	IN
cord-048322-5eqdrd52	82	30	<	<	XX
cord-048322-5eqdrd52	82	31	1000	1000	CD
cord-048322-5eqdrd52	82	32	Da	Da	NNP
cord-048322-5eqdrd52	82	33	to	to	IN
cord-048322-5eqdrd52	82	34	>	>	XX
cord-048322-5eqdrd52	82	35	1000	1000	CD
cord-048322-5eqdrd52	82	36	kd	kd	NN
cord-048322-5eqdrd52	82	37	.	.	.
cord-048322-5eqdrd52	83	1	Commercial	commercial	JJ
cord-048322-5eqdrd52	83	2	PEI	PEI	NNP
cord-048322-5eqdrd52	83	3	preparations	preparation	NNS
cord-048322-5eqdrd52	83	4	,	,	,
cord-048322-5eqdrd52	83	5	although	although	IN
cord-048322-5eqdrd52	83	6	labelled	label	VBN
cord-048322-5eqdrd52	83	7	with	with	IN
cord-048322-5eqdrd52	83	8	a	a	DT
cord-048322-5eqdrd52	83	9	defined	define	VBN
cord-048322-5eqdrd52	83	10	molecular	molecular	JJ
cord-048322-5eqdrd52	83	11	weight	weight	NN
cord-048322-5eqdrd52	83	12	,	,	,
cord-048322-5eqdrd52	83	13	consist	consist	VBP
cord-048322-5eqdrd52	83	14	of	of	IN
cord-048322-5eqdrd52	83	15	PEI	PEI	NNP
cord-048322-5eqdrd52	83	16	molecules	molecule	NNS
cord-048322-5eqdrd52	83	17	with	with	IN
cord-048322-5eqdrd52	83	18	a	a	DT
cord-048322-5eqdrd52	83	19	broad	broad	JJ
cord-048322-5eqdrd52	83	20	molecular	molecular	JJ
cord-048322-5eqdrd52	83	21	weight	weight	NN
cord-048322-5eqdrd52	83	22	distribution	distribution	NN
cord-048322-5eqdrd52	83	23	[	[	-LRB-
cord-048322-5eqdrd52	83	24	45	45	CD
cord-048322-5eqdrd52	83	25	]	]	-RRB-
cord-048322-5eqdrd52	83	26	[	[	-LRB-
cord-048322-5eqdrd52	83	27	46	46	CD
cord-048322-5eqdrd52	83	28	]	]	-RRB-
cord-048322-5eqdrd52	83	29	[	[	-LRB-
cord-048322-5eqdrd52	83	30	47	47	CD
cord-048322-5eqdrd52	83	31	]	]	-RRB-
cord-048322-5eqdrd52	83	32	.	.	.
cord-048322-5eqdrd52	84	1	PEIs	PEIs	NNPS
cord-048322-5eqdrd52	84	2	possess	possess	VBP
cord-048322-5eqdrd52	84	3	a	a	DT
cord-048322-5eqdrd52	84	4	high	high	JJ
cord-048322-5eqdrd52	84	5	cationic	cationic	JJ
cord-048322-5eqdrd52	84	6	charge	charge	NN
cord-048322-5eqdrd52	84	7	density	density	NN
cord-048322-5eqdrd52	84	8	due	due	IN
cord-048322-5eqdrd52	84	9	to	to	IN
cord-048322-5eqdrd52	84	10	a	a	DT
cord-048322-5eqdrd52	84	11	protonable	protonable	JJ
cord-048322-5eqdrd52	84	12	amino	amino	NN
cord-048322-5eqdrd52	84	13	group	group	NN
cord-048322-5eqdrd52	84	14	in	in	IN
cord-048322-5eqdrd52	84	15	every	every	DT
cord-048322-5eqdrd52	84	16	third	third	JJ
cord-048322-5eqdrd52	84	17	position	position	NN
cord-048322-5eqdrd52	84	18	[	[	-LRB-
cord-048322-5eqdrd52	84	19	48	48	CD
cord-048322-5eqdrd52	84	20	,	,	,
cord-048322-5eqdrd52	84	21	49	49	CD
cord-048322-5eqdrd52	84	22	]	]	-RRB-
cord-048322-5eqdrd52	84	23	.	.	.
cord-048322-5eqdrd52	85	1	Since	since	IN
cord-048322-5eqdrd52	85	2	no	no	DT
cord-048322-5eqdrd52	85	3	quarternary	quarternary	JJ
cord-048322-5eqdrd52	85	4	amino	amino	NNS
cord-048322-5eqdrd52	85	5	groups	group	NNS
cord-048322-5eqdrd52	85	6	are	be	VBP
cord-048322-5eqdrd52	85	7	present	present	JJ
cord-048322-5eqdrd52	85	8	,	,	,
cord-048322-5eqdrd52	85	9	the	the	DT
cord-048322-5eqdrd52	85	10	cationic	cationic	JJ
cord-048322-5eqdrd52	85	11	charges	charge	NNS
cord-048322-5eqdrd52	85	12	are	be	VBP
cord-048322-5eqdrd52	85	13	generated	generate	VBN
cord-048322-5eqdrd52	85	14	by	by	IN
cord-048322-5eqdrd52	85	15	protonation	protonation	NN
cord-048322-5eqdrd52	85	16	of	of	IN
cord-048322-5eqdrd52	85	17	the	the	DT
cord-048322-5eqdrd52	85	18	amino	amino	NN
cord-048322-5eqdrd52	85	19	groups	group	NNS
cord-048322-5eqdrd52	85	20	and	and	CC
cord-048322-5eqdrd52	85	21	hence	hence	RB
cord-048322-5eqdrd52	85	22	are	be	VBP
cord-048322-5eqdrd52	85	23	dependent	dependent	JJ
cord-048322-5eqdrd52	85	24	on	on	IN
cord-048322-5eqdrd52	85	25	the	the	DT
cord-048322-5eqdrd52	85	26	pH	ph	NN
cord-048322-5eqdrd52	85	27	in	in	IN
cord-048322-5eqdrd52	85	28	the	the	DT
cord-048322-5eqdrd52	85	29	environment	environment	NN
cord-048322-5eqdrd52	85	30	(	(	-LRB-
cord-048322-5eqdrd52	85	31	eg	eg	RB
cord-048322-5eqdrd52	85	32	,	,	,
cord-048322-5eqdrd52	85	33	20	20	CD
cord-048322-5eqdrd52	85	34	%	%	NN
cord-048322-5eqdrd52	85	35	at	at	IN
cord-048322-5eqdrd52	85	36	pH	pH	NNP
cord-048322-5eqdrd52	85	37	7.4	7.4	CD
cord-048322-5eqdrd52	85	38	,	,	,
cord-048322-5eqdrd52	85	39	see	see	VB
cord-048322-5eqdrd52	85	40	[	[	-LRB-
cord-048322-5eqdrd52	85	41	50	50	CD
cord-048322-5eqdrd52	85	42	]	]	-RRB-
cord-048322-5eqdrd52	85	43	for	for	IN
cord-048322-5eqdrd52	85	44	review	review	NN
cord-048322-5eqdrd52	85	45	)	)	-RRB-
cord-048322-5eqdrd52	85	46	.	.	.
cord-048322-5eqdrd52	86	1	Due	due	IN
cord-048322-5eqdrd52	86	2	to	to	IN
cord-048322-5eqdrd52	86	3	its	-PRON-	PRP$
cord-048322-5eqdrd52	86	4	ability	ability	NN
cord-048322-5eqdrd52	86	5	to	to	TO
cord-048322-5eqdrd52	86	6	condense	condense	VB
cord-048322-5eqdrd52	86	7	and	and	CC
cord-048322-5eqdrd52	86	8	compact	compact	VB
cord-048322-5eqdrd52	86	9	the	the	DT
cord-048322-5eqdrd52	86	10	DNA	dna	NN
cord-048322-5eqdrd52	86	11	into	into	IN
cord-048322-5eqdrd52	86	12	complexes	complex	NNS
cord-048322-5eqdrd52	86	13	,	,	,
cord-048322-5eqdrd52	86	14	which	which	WDT
cord-048322-5eqdrd52	86	15	form	form	VBP
cord-048322-5eqdrd52	86	16	small	small	JJ
cord-048322-5eqdrd52	86	17	colloidal	colloidal	NN
cord-048322-5eqdrd52	86	18	particles	particle	NNS
cord-048322-5eqdrd52	86	19	allowing	allow	VBG
cord-048322-5eqdrd52	86	20	efficient	efficient	JJ
cord-048322-5eqdrd52	86	21	cellular	cellular	JJ
cord-048322-5eqdrd52	86	22	uptake	uptake	NN
cord-048322-5eqdrd52	86	23	through	through	IN
cord-048322-5eqdrd52	86	24	endocytosis	endocytosis	NN
cord-048322-5eqdrd52	86	25	,	,	,
cord-048322-5eqdrd52	86	26	PEI	PEI	NNP
cord-048322-5eqdrd52	86	27	has	have	VBZ
cord-048322-5eqdrd52	86	28	been	be	VBN
cord-048322-5eqdrd52	86	29	introduced	introduce	VBN
cord-048322-5eqdrd52	86	30	as	as	IN
cord-048322-5eqdrd52	86	31	a	a	DT
cord-048322-5eqdrd52	86	32	potent	potent	JJ
cord-048322-5eqdrd52	86	33	DNA	dna	NN
cord-048322-5eqdrd52	86	34	transfection	transfection	NN
cord-048322-5eqdrd52	86	35	reagent	reagent	NN
cord-048322-5eqdrd52	86	36	in	in	IN
cord-048322-5eqdrd52	86	37	a	a	DT
cord-048322-5eqdrd52	86	38	variety	variety	NN
cord-048322-5eqdrd52	86	39	of	of	IN
cord-048322-5eqdrd52	86	40	cell	cell	NN
cord-048322-5eqdrd52	86	41	lines	line	NNS
cord-048322-5eqdrd52	86	42	and	and	CC
cord-048322-5eqdrd52	86	43	in	in	IN
cord-048322-5eqdrd52	86	44	animals	animal	NNS
cord-048322-5eqdrd52	86	45	for	for	IN
cord-048322-5eqdrd52	86	46	DNA	dna	NN
cord-048322-5eqdrd52	86	47	delivery	delivery	NN
cord-048322-5eqdrd52	86	48	(	(	-LRB-
cord-048322-5eqdrd52	86	49	for	for	IN
cord-048322-5eqdrd52	86	50	review	review	NN
cord-048322-5eqdrd52	86	51	,	,	,
cord-048322-5eqdrd52	86	52	see	see	VB
cord-048322-5eqdrd52	86	53	[	[	-LRB-
cord-048322-5eqdrd52	86	54	51	51	CD
cord-048322-5eqdrd52	86	55	,	,	,
cord-048322-5eqdrd52	86	56	52	52	CD
cord-048322-5eqdrd52	86	57	]	]	-RRB-
cord-048322-5eqdrd52	86	58	and	and	CC
cord-048322-5eqdrd52	86	59	references	reference	NNS
cord-048322-5eqdrd52	86	60	therein	therein	RB
cord-048322-5eqdrd52	86	61	)	)	-RRB-
cord-048322-5eqdrd52	86	62	.	.	.
cord-048322-5eqdrd52	87	1	In	in	IN
cord-048322-5eqdrd52	87	2	fact	fact	NN
cord-048322-5eqdrd52	87	3	,	,	,
cord-048322-5eqdrd52	87	4	in	in	IN
cord-048322-5eqdrd52	87	5	several	several	JJ
cord-048322-5eqdrd52	87	6	studies	study	NNS
cord-048322-5eqdrd52	87	7	PEI	PEI	NNP
cord-048322-5eqdrd52	87	8	has	have	VBZ
cord-048322-5eqdrd52	87	9	been	be	VBN
cord-048322-5eqdrd52	87	10	shown	show	VBN
cord-048322-5eqdrd52	87	11	to	to	TO
cord-048322-5eqdrd52	87	12	be	be	VB
cord-048322-5eqdrd52	87	13	able	able	JJ
cord-048322-5eqdrd52	87	14	to	to	TO
cord-048322-5eqdrd52	87	15	deliver	deliver	VB
cord-048322-5eqdrd52	87	16	large	large	JJ
cord-048322-5eqdrd52	87	17	DNA	dna	NN
cord-048322-5eqdrd52	87	18	molecules	molecule	NNS
cord-048322-5eqdrd52	87	19	such	such	JJ
cord-048322-5eqdrd52	87	20	as	as	IN
cord-048322-5eqdrd52	87	21	2.3	2.3	CD
cord-048322-5eqdrd52	87	22	Mb	Mb	NNP
cord-048322-5eqdrd52	87	23	yeast	yeast	NN
cord-048322-5eqdrd52	87	24	artificial	artificial	JJ
cord-048322-5eqdrd52	87	25	chromosomes	chromosome	NNS
cord-048322-5eqdrd52	87	26	(	(	-LRB-
cord-048322-5eqdrd52	87	27	YACs	yac	NNS
cord-048322-5eqdrd52	87	28	)	)	-RRB-
cord-048322-5eqdrd52	87	29	[	[	-LRB-
cord-048322-5eqdrd52	87	30	53	53	CD
cord-048322-5eqdrd52	87	31	]	]	-RRB-
cord-048322-5eqdrd52	87	32	as	as	RB
cord-048322-5eqdrd52	87	33	well	well	RB
cord-048322-5eqdrd52	87	34	as	as	IN
cord-048322-5eqdrd52	87	35	plasmids	plasmid	NNS
cord-048322-5eqdrd52	87	36	or	or	CC
cord-048322-5eqdrd52	87	37	small	small	JJ
cord-048322-5eqdrd52	87	38	oligonucleotides	oligonucleotide	NNS
cord-048322-5eqdrd52	87	39	[	[	-LRB-
cord-048322-5eqdrd52	87	40	48	48	CD
cord-048322-5eqdrd52	87	41	,	,	,
cord-048322-5eqdrd52	87	42	[	[	-LRB-
cord-048322-5eqdrd52	87	43	54	54	CD
cord-048322-5eqdrd52	87	44	]	]	-RRB-
cord-048322-5eqdrd52	88	1	[	[	-LRB-
cord-048322-5eqdrd52	88	2	55	55	CD
cord-048322-5eqdrd52	88	3	]	]	-RRB-
cord-048322-5eqdrd52	88	4	[	[	-LRB-
cord-048322-5eqdrd52	88	5	56	56	CD
cord-048322-5eqdrd52	88	6	]	]	-RRB-
cord-048322-5eqdrd52	88	7	into	into	IN
cord-048322-5eqdrd52	88	8	mammalian	mammalian	JJ
cord-048322-5eqdrd52	88	9	cells	cell	NNS
cord-048322-5eqdrd52	88	10	in	in	IN
cord-048322-5eqdrd52	88	11	vitro	vitro	FW
cord-048322-5eqdrd52	88	12	and	and	CC
cord-048322-5eqdrd52	88	13	in	in	IN
cord-048322-5eqdrd52	88	14	vivo	vivo	NNP
cord-048322-5eqdrd52	88	15	.	.	.
cord-048322-5eqdrd52	89	1	The	the	DT
cord-048322-5eqdrd52	89	2	N	N	NNP
cord-048322-5eqdrd52	89	3	/	/	SYM
cord-048322-5eqdrd52	89	4	P	p	NN
cord-048322-5eqdrd52	89	5	ratio	ratio	NN
cord-048322-5eqdrd52	89	6	,	,	,
cord-048322-5eqdrd52	89	7	which	which	WDT
cord-048322-5eqdrd52	89	8	indicates	indicate	VBZ
cord-048322-5eqdrd52	89	9	the	the	DT
cord-048322-5eqdrd52	89	10	ratio	ratio	NN
cord-048322-5eqdrd52	89	11	of	of	IN
cord-048322-5eqdrd52	89	12	the	the	DT
cord-048322-5eqdrd52	89	13	nitrogen	nitrogen	NN
cord-048322-5eqdrd52	89	14	atoms	atom	NNS
cord-048322-5eqdrd52	89	15	of	of	IN
cord-048322-5eqdrd52	89	16	PEI	PEI	NNP
cord-048322-5eqdrd52	89	17	to	to	IN
cord-048322-5eqdrd52	89	18	DNA	dna	NN
cord-048322-5eqdrd52	89	19	phosphates	phosphate	NNS
cord-048322-5eqdrd52	89	20	in	in	IN
cord-048322-5eqdrd52	89	21	the	the	DT
cord-048322-5eqdrd52	89	22	complex	complex	NN
cord-048322-5eqdrd52	89	23	and	and	CC
cord-048322-5eqdrd52	89	24	thus	thus	RB
cord-048322-5eqdrd52	89	25	describes	describe	VBZ
cord-048322-5eqdrd52	89	26	the	the	DT
cord-048322-5eqdrd52	89	27	amount	amount	NN
cord-048322-5eqdrd52	89	28	of	of	IN
cord-048322-5eqdrd52	89	29	PEI	PEI	NNP
cord-048322-5eqdrd52	89	30	used	use	VBN
cord-048322-5eqdrd52	89	31	for	for	IN
cord-048322-5eqdrd52	89	32	complex	complex	JJ
cord-048322-5eqdrd52	89	33	formation	formation	NN
cord-048322-5eqdrd52	89	34	independent	independent	JJ
cord-048322-5eqdrd52	89	35	of	of	IN
cord-048322-5eqdrd52	89	36	its	-PRON-	PRP$
cord-048322-5eqdrd52	89	37	molecular	molecular	JJ
cord-048322-5eqdrd52	89	38	weight	weight	NN
cord-048322-5eqdrd52	89	39	,	,	,
cord-048322-5eqdrd52	89	40	influences	influence	VBZ
cord-048322-5eqdrd52	89	41	the	the	DT
cord-048322-5eqdrd52	89	42	efficiency	efficiency	NN
cord-048322-5eqdrd52	89	43	of	of	IN
cord-048322-5eqdrd52	89	44	DNA	dna	NN
cord-048322-5eqdrd52	89	45	delivery	delivery	NN
cord-048322-5eqdrd52	89	46	.	.	.
cord-048322-5eqdrd52	90	1	A	a	DT
cord-048322-5eqdrd52	90	2	positive	positive	JJ
cord-048322-5eqdrd52	90	3	net	net	JJ
cord-048322-5eqdrd52	90	4	charge	charge	NN
cord-048322-5eqdrd52	90	5	of	of	IN
cord-048322-5eqdrd52	90	6	the	the	DT
cord-048322-5eqdrd52	90	7	complexes	complex	NNS
cord-048322-5eqdrd52	90	8	,	,	,
cord-048322-5eqdrd52	90	9	resulting	result	VBG
cord-048322-5eqdrd52	90	10	from	from	IN
cord-048322-5eqdrd52	90	11	high	high	JJ
cord-048322-5eqdrd52	90	12	N	n	CD
cord-048322-5eqdrd52	90	13	/	/	SYM
cord-048322-5eqdrd52	90	14	P	p	NN
cord-048322-5eqdrd52	90	15	ratios	ratio	NNS
cord-048322-5eqdrd52	90	16	,	,	,
cord-048322-5eqdrd52	90	17	inhibits	inhibit	VBZ
cord-048322-5eqdrd52	90	18	due	due	IN
cord-048322-5eqdrd52	90	19	to	to	IN
cord-048322-5eqdrd52	90	20	electrostatic	electrostatic	JJ
cord-048322-5eqdrd52	90	21	repulsion	repulsion	NN
cord-048322-5eqdrd52	90	22	their	-PRON-	PRP$
cord-048322-5eqdrd52	90	23	aggregation	aggregation	NN
cord-048322-5eqdrd52	90	24	and	and	CC
cord-048322-5eqdrd52	90	25	improves	improve	VBZ
cord-048322-5eqdrd52	90	26	their	-PRON-	PRP$
cord-048322-5eqdrd52	90	27	solubility	solubility	NN
cord-048322-5eqdrd52	90	28	in	in	IN
cord-048322-5eqdrd52	90	29	aqueous	aqueous	JJ
cord-048322-5eqdrd52	90	30	solutions	solution	NNS
cord-048322-5eqdrd52	90	31	as	as	RB
cord-048322-5eqdrd52	90	32	well	well	RB
cord-048322-5eqdrd52	90	33	as	as	IN
cord-048322-5eqdrd52	90	34	their	-PRON-	PRP$
cord-048322-5eqdrd52	90	35	interaction	interaction	NN
cord-048322-5eqdrd52	90	36	with	with	IN
cord-048322-5eqdrd52	90	37	the	the	DT
cord-048322-5eqdrd52	90	38	negatively	negatively	RB
cord-048322-5eqdrd52	90	39	charged	charge	VBN
cord-048322-5eqdrd52	90	40	extracellular	extracellular	JJ
cord-048322-5eqdrd52	90	41	matrix	matrix	NN
cord-048322-5eqdrd52	90	42	components	component	NNS
cord-048322-5eqdrd52	90	43	and	and	CC
cord-048322-5eqdrd52	90	44	thus	thus	RB
cord-048322-5eqdrd52	90	45	their	-PRON-	PRP$
cord-048322-5eqdrd52	90	46	cellular	cellular	JJ
cord-048322-5eqdrd52	90	47	uptake	uptake	NN
cord-048322-5eqdrd52	90	48	[	[	-LRB-
cord-048322-5eqdrd52	90	49	57	57	CD
cord-048322-5eqdrd52	90	50	]	]	-RRB-
cord-048322-5eqdrd52	90	51	.	.	.
cord-048322-5eqdrd52	91	1	Additionally	additionally	RB
cord-048322-5eqdrd52	91	2	,	,	,
cord-048322-5eqdrd52	91	3	the	the	DT
cord-048322-5eqdrd52	91	4	strong	strong	JJ
cord-048322-5eqdrd52	91	5	buffer	buffer	NN
cord-048322-5eqdrd52	91	6	capacity	capacity	NN
cord-048322-5eqdrd52	91	7	,	,	,
cord-048322-5eqdrd52	91	8	described	describe	VBN
cord-048322-5eqdrd52	91	9	by	by	IN
cord-048322-5eqdrd52	91	10	the	the	DT
cord-048322-5eqdrd52	91	11	"	"	``
cord-048322-5eqdrd52	91	12	proton	proton	NN
cord-048322-5eqdrd52	91	13	sponge	sponge	NN
cord-048322-5eqdrd52	91	14	hypothesis	hypothesis	NN
cord-048322-5eqdrd52	91	15	"	"	''
cord-048322-5eqdrd52	91	16	which	which	WDT
cord-048322-5eqdrd52	91	17	postulates	postulate	VBZ
cord-048322-5eqdrd52	91	18	enhanced	enhance	VBN
cord-048322-5eqdrd52	91	19	transgene	transgene	NN
cord-048322-5eqdrd52	91	20	delivery	delivery	NN
cord-048322-5eqdrd52	91	21	by	by	IN
cord-048322-5eqdrd52	91	22	cationic	cationic	JJ
cord-048322-5eqdrd52	91	23	polymer	polymer	NN
cord-048322-5eqdrd52	91	24	-	-	HYPH
cord-048322-5eqdrd52	91	25	DNA	dna	NN
cord-048322-5eqdrd52	91	26	complexes	complex	NNS
cord-048322-5eqdrd52	91	27	(	(	-LRB-
cord-048322-5eqdrd52	91	28	polyplexes	polyplexes	NNP
cord-048322-5eqdrd52	91	29	)	)	-RRB-
cord-048322-5eqdrd52	91	30	containing	contain	VBG
cord-048322-5eqdrd52	91	31	H	h	NN
cord-048322-5eqdrd52	91	32	+	+	CC
cord-048322-5eqdrd52	91	33	buffering	buffering	NN
cord-048322-5eqdrd52	91	34	polyamines	polyamine	NNS
cord-048322-5eqdrd52	91	35	due	due	JJ
cord-048322-5eqdrd52	91	36	to	to	IN
cord-048322-5eqdrd52	91	37	enhanced	enhance	VBN
cord-048322-5eqdrd52	91	38	endosomal	endosomal	NNP
cord-048322-5eqdrd52	91	39	Cl	Cl	NNP
cord-048322-5eqdrd52	91	40	−	−	NNP
cord-048322-5eqdrd52	91	41	accumulation	accumulation	NN
cord-048322-5eqdrd52	91	42	and	and	CC
cord-048322-5eqdrd52	91	43	osmotic	osmotic	JJ
cord-048322-5eqdrd52	91	44	swelling	swelling	NN
cord-048322-5eqdrd52	91	45	/	/	SYM
cord-048322-5eqdrd52	91	46	lysis	lysis	NN
cord-048322-5eqdrd52	91	47	[	[	-LRB-
cord-048322-5eqdrd52	91	48	48	48	CD
cord-048322-5eqdrd52	91	49	]	]	-RRB-
cord-048322-5eqdrd52	91	50	,	,	,
cord-048322-5eqdrd52	91	51	seems	seem	VBZ
cord-048322-5eqdrd52	91	52	to	to	TO
cord-048322-5eqdrd52	91	53	be	be	VB
cord-048322-5eqdrd52	91	54	responsible	responsible	JJ
cord-048322-5eqdrd52	91	55	for	for	IN
cord-048322-5eqdrd52	91	56	the	the	DT
cord-048322-5eqdrd52	91	57	fact	fact	NN
cord-048322-5eqdrd52	91	58	that	that	IN
cord-048322-5eqdrd52	91	59	PEI	PEI	NNP
cord-048322-5eqdrd52	91	60	-	-	HYPH
cord-048322-5eqdrd52	91	61	based	base	VBN
cord-048322-5eqdrd52	91	62	delivery	delivery	NN
cord-048322-5eqdrd52	91	63	does	do	VBZ
cord-048322-5eqdrd52	91	64	not	not	RB
cord-048322-5eqdrd52	91	65	require	require	VB
cord-048322-5eqdrd52	91	66	endosome	endosome	NN
cord-048322-5eqdrd52	91	67	disruptive	disruptive	JJ
cord-048322-5eqdrd52	91	68	agents	agent	NNS
cord-048322-5eqdrd52	91	69	for	for	IN
cord-048322-5eqdrd52	91	70	lysosomal	lysosomal	JJ
cord-048322-5eqdrd52	91	71	escape	escape	NN
cord-048322-5eqdrd52	91	72	.	.	.
cord-048322-5eqdrd52	92	1	This	this	DT
cord-048322-5eqdrd52	92	2	tight	tight	JJ
cord-048322-5eqdrd52	92	3	condensation	condensation	NN
cord-048322-5eqdrd52	92	4	of	of	IN
cord-048322-5eqdrd52	92	5	the	the	DT
cord-048322-5eqdrd52	92	6	DNA	dna	NN
cord-048322-5eqdrd52	92	7	molecules	molecule	NNS
cord-048322-5eqdrd52	92	8	as	as	RB
cord-048322-5eqdrd52	92	9	well	well	RB
cord-048322-5eqdrd52	92	10	as	as	IN
cord-048322-5eqdrd52	92	11	the	the	DT
cord-048322-5eqdrd52	92	12	buffering	buffering	NN
cord-048322-5eqdrd52	92	13	capacity	capacity	NN
cord-048322-5eqdrd52	92	14	of	of	IN
cord-048322-5eqdrd52	92	15	PEI	PEI	NNP
cord-048322-5eqdrd52	92	16	in	in	IN
cord-048322-5eqdrd52	92	17	certain	certain	JJ
cord-048322-5eqdrd52	92	18	cellular	cellular	JJ
cord-048322-5eqdrd52	92	19	compartments	compartment	NNS
cord-048322-5eqdrd52	92	20	like	like	IN
cord-048322-5eqdrd52	92	21	endosomes	endosome	NNS
cord-048322-5eqdrd52	92	22	and	and	CC
cord-048322-5eqdrd52	92	23	lysosomes	lysosome	NNS
cord-048322-5eqdrd52	92	24	also	also	RB
cord-048322-5eqdrd52	92	25	protects	protect	VBZ
cord-048322-5eqdrd52	92	26	DNA	dna	NN
cord-048322-5eqdrd52	92	27	from	from	IN
cord-048322-5eqdrd52	92	28	degradation	degradation	NN
cord-048322-5eqdrd52	92	29	[	[	-LRB-
cord-048322-5eqdrd52	92	30	48	48	CD
cord-048322-5eqdrd52	92	31	,	,	,
cord-048322-5eqdrd52	92	32	49	49	CD
cord-048322-5eqdrd52	92	33	,	,	,
cord-048322-5eqdrd52	92	34	58	58	CD
cord-048322-5eqdrd52	92	35	,	,	,
cord-048322-5eqdrd52	92	36	59	59	CD
cord-048322-5eqdrd52	92	37	]	]	-RRB-
cord-048322-5eqdrd52	92	38	.	.	.
cord-048322-5eqdrd52	93	1	PEIs	pei	NNS
cord-048322-5eqdrd52	93	2	have	have	VBP
cord-048322-5eqdrd52	93	3	been	be	VBN
cord-048322-5eqdrd52	93	4	successfully	successfully	RB
cord-048322-5eqdrd52	93	5	used	use	VBN
cord-048322-5eqdrd52	93	6	for	for	IN
cord-048322-5eqdrd52	93	7	nonviral	nonviral	JJ
cord-048322-5eqdrd52	93	8	gene	gene	NN
cord-048322-5eqdrd52	93	9	delivery	delivery	NN
cord-048322-5eqdrd52	93	10	in	in	IN
cord-048322-5eqdrd52	93	11	vitro	vitro	FW
cord-048322-5eqdrd52	93	12	and	and	CC
cord-048322-5eqdrd52	93	13	in	in	IN
cord-048322-5eqdrd52	93	14	vivo	vivo	NNP
cord-048322-5eqdrd52	93	15	.	.	.
cord-048322-5eqdrd52	94	1	While	while	IN
cord-048322-5eqdrd52	94	2	initial	initial	JJ
cord-048322-5eqdrd52	94	3	publications	publication	NNS
cord-048322-5eqdrd52	94	4	showed	show	VBD
cord-048322-5eqdrd52	94	5	increased	increased	JJ
cord-048322-5eqdrd52	94	6	transfection	transfection	NN
cord-048322-5eqdrd52	94	7	efficacies	efficacy	NNS
cord-048322-5eqdrd52	94	8	when	when	WRB
cord-048322-5eqdrd52	94	9	using	use	VBG
cord-048322-5eqdrd52	94	10	high	high	JJ
cord-048322-5eqdrd52	94	11	molecular	molecular	JJ
cord-048322-5eqdrd52	94	12	weight	weight	NN
cord-048322-5eqdrd52	94	13	PEIs	pei	NNS
cord-048322-5eqdrd52	94	14	[	[	-LRB-
cord-048322-5eqdrd52	94	15	45	45	CD
cord-048322-5eqdrd52	94	16	]	]	-RRB-
cord-048322-5eqdrd52	94	17	,	,	,
cord-048322-5eqdrd52	94	18	more	more	RBR
cord-048322-5eqdrd52	94	19	recent	recent	JJ
cord-048322-5eqdrd52	94	20	studies	study	NNS
cord-048322-5eqdrd52	94	21	demonstrated	demonstrate	VBD
cord-048322-5eqdrd52	94	22	the	the	DT
cord-048322-5eqdrd52	94	23	advantages	advantage	NNS
cord-048322-5eqdrd52	94	24	of	of	IN
cord-048322-5eqdrd52	94	25	certain	certain	JJ
cord-048322-5eqdrd52	94	26	low	low	JJ
cord-048322-5eqdrd52	94	27	molecular	molecular	JJ
cord-048322-5eqdrd52	94	28	weight	weight	NN
cord-048322-5eqdrd52	94	29	PEIs	pei	NNS
cord-048322-5eqdrd52	94	30	[	[	-LRB-
cord-048322-5eqdrd52	94	31	47	47	CD
cord-048322-5eqdrd52	94	32	,	,	,
cord-048322-5eqdrd52	94	33	60	60	CD
cord-048322-5eqdrd52	94	34	,	,	,
cord-048322-5eqdrd52	94	35	61	61	CD
cord-048322-5eqdrd52	94	36	]	]	-RRB-
cord-048322-5eqdrd52	94	37	.	.	.
cord-048322-5eqdrd52	95	1	The	the	DT
cord-048322-5eqdrd52	95	2	higher	high	JJR
cord-048322-5eqdrd52	95	3	transfection	transfection	NN
cord-048322-5eqdrd52	95	4	efficacy	efficacy	NN
cord-048322-5eqdrd52	95	5	of	of	IN
cord-048322-5eqdrd52	95	6	low	low	JJ
cord-048322-5eqdrd52	95	7	molecular	molecular	JJ
cord-048322-5eqdrd52	95	8	weight	weight	NN
cord-048322-5eqdrd52	95	9	PEIs	pei	NNS
cord-048322-5eqdrd52	95	10	may	may	MD
cord-048322-5eqdrd52	95	11	be	be	VB
cord-048322-5eqdrd52	95	12	due	due	JJ
cord-048322-5eqdrd52	95	13	to	to	IN
cord-048322-5eqdrd52	95	14	a	a	DT
cord-048322-5eqdrd52	95	15	more	more	RBR
cord-048322-5eqdrd52	95	16	efficient	efficient	JJ
cord-048322-5eqdrd52	95	17	uptake	uptake	NN
cord-048322-5eqdrd52	95	18	of	of	IN
cord-048322-5eqdrd52	95	19	the	the	DT
cord-048322-5eqdrd52	95	20	resulting	result	VBG
cord-048322-5eqdrd52	95	21	PEI	PEI	NNP
cord-048322-5eqdrd52	95	22	/	/	SYM
cord-048322-5eqdrd52	95	23	DNA	dna	NN
cord-048322-5eqdrd52	95	24	complexes	complex	NNS
cord-048322-5eqdrd52	95	25	,	,	,
cord-048322-5eqdrd52	95	26	a	a	DT
cord-048322-5eqdrd52	95	27	better	well	RBR
cord-048322-5eqdrd52	95	28	intracellular	intracellular	JJ
cord-048322-5eqdrd52	95	29	release	release	NN
cord-048322-5eqdrd52	95	30	of	of	IN
cord-048322-5eqdrd52	95	31	the	the	DT
cord-048322-5eqdrd52	95	32	DNA	dna	NN
cord-048322-5eqdrd52	95	33	and/or	and/or	CC
cord-048322-5eqdrd52	95	34	lower	lower	RBR
cord-048322-5eqdrd52	95	35	in	in	IN
cord-048322-5eqdrd52	95	36	vitro	vitro	FW
cord-048322-5eqdrd52	95	37	cytotoxicity	cytotoxicity	NN
cord-048322-5eqdrd52	95	38	as	as	IN
cord-048322-5eqdrd52	95	39	compared	compare	VBN
cord-048322-5eqdrd52	95	40	to	to	IN
cord-048322-5eqdrd52	95	41	high	high	JJ
cord-048322-5eqdrd52	95	42	molecular	molecular	JJ
cord-048322-5eqdrd52	95	43	weight	weight	NN
cord-048322-5eqdrd52	95	44	PEI	PEI	NNP
cord-048322-5eqdrd52	95	45	[	[	-LRB-
cord-048322-5eqdrd52	95	46	60	60	CD
cord-048322-5eqdrd52	95	47	]	]	-RRB-
cord-048322-5eqdrd52	95	48	[	[	-LRB-
cord-048322-5eqdrd52	95	49	61	61	CD
cord-048322-5eqdrd52	95	50	]	]	-RRB-
cord-048322-5eqdrd52	95	51	[	[	-LRB-
cord-048322-5eqdrd52	95	52	62	62	CD
cord-048322-5eqdrd52	95	53	]	]	-RRB-
cord-048322-5eqdrd52	95	54	[	[	-LRB-
cord-048322-5eqdrd52	95	55	63	63	CD
cord-048322-5eqdrd52	95	56	]	]	-RRB-
cord-048322-5eqdrd52	95	57	.	.	.
cord-048322-5eqdrd52	96	1	In	in	IN
cord-048322-5eqdrd52	96	2	fact	fact	NN
cord-048322-5eqdrd52	96	3	,	,	,
cord-048322-5eqdrd52	96	4	a	a	DT
cord-048322-5eqdrd52	96	5	decrease	decrease	NN
cord-048322-5eqdrd52	96	6	in	in	IN
cord-048322-5eqdrd52	96	7	the	the	DT
cord-048322-5eqdrd52	96	8	molecular	molecular	JJ
cord-048322-5eqdrd52	96	9	weight	weight	NN
cord-048322-5eqdrd52	96	10	of	of	IN
cord-048322-5eqdrd52	96	11	the	the	DT
cord-048322-5eqdrd52	96	12	PEI	PEI	NNP
cord-048322-5eqdrd52	96	13	leads	lead	VBZ
cord-048322-5eqdrd52	96	14	to	to	IN
cord-048322-5eqdrd52	96	15	an	an	DT
cord-048322-5eqdrd52	96	16	increase	increase	NN
cord-048322-5eqdrd52	96	17	in	in	IN
cord-048322-5eqdrd52	96	18	complex	complex	JJ
cord-048322-5eqdrd52	96	19	size	size	NN
cord-048322-5eqdrd52	96	20	which	which	WDT
cord-048322-5eqdrd52	96	21	may	may	MD
cord-048322-5eqdrd52	96	22	be	be	VB
cord-048322-5eqdrd52	96	23	favourable	favourable	JJ
cord-048322-5eqdrd52	96	24	at	at	IN
cord-048322-5eqdrd52	96	25	least	least	JJS
cord-048322-5eqdrd52	96	26	for	for	IN
cord-048322-5eqdrd52	96	27	in	in	FW
cord-048322-5eqdrd52	96	28	vitro	vitro	FW
cord-048322-5eqdrd52	96	29	use	use	VBP
cord-048322-5eqdrd52	96	30	[	[	-LRB-
cord-048322-5eqdrd52	96	31	64	64	CD
cord-048322-5eqdrd52	96	32	,	,	,
cord-048322-5eqdrd52	96	33	65	65	CD
cord-048322-5eqdrd52	96	34	]	]	-RRB-
cord-048322-5eqdrd52	96	35	.	.	.
cord-048322-5eqdrd52	97	1	On	on	IN
cord-048322-5eqdrd52	97	2	the	the	DT
cord-048322-5eqdrd52	97	3	other	other	JJ
cord-048322-5eqdrd52	97	4	hand	hand	NN
cord-048322-5eqdrd52	97	5	,	,	,
cord-048322-5eqdrd52	97	6	other	other	JJ
cord-048322-5eqdrd52	97	7	PEIs	pei	NNS
cord-048322-5eqdrd52	97	8	with	with	IN
cord-048322-5eqdrd52	97	9	very	very	RB
cord-048322-5eqdrd52	97	10	low	low	JJ
cord-048322-5eqdrd52	97	11	molecular	molecular	JJ
cord-048322-5eqdrd52	97	12	weight	weight	NN
cord-048322-5eqdrd52	97	13	(	(	-LRB-
cord-048322-5eqdrd52	97	14	<	<	NNP
cord-048322-5eqdrd52	97	15	2	2	CD
cord-048322-5eqdrd52	97	16	kd	kd	NNP
cord-048322-5eqdrd52	97	17	)	)	-RRB-
cord-048322-5eqdrd52	97	18	display	display	VBP
cord-048322-5eqdrd52	97	19	little	little	JJ
cord-048322-5eqdrd52	97	20	or	or	CC
cord-048322-5eqdrd52	97	21	no	no	DT
cord-048322-5eqdrd52	97	22	transfection	transfection	NN
cord-048322-5eqdrd52	97	23	efficacy	efficacy	NN
cord-048322-5eqdrd52	97	24	even	even	RB
cord-048322-5eqdrd52	97	25	at	at	IN
cord-048322-5eqdrd52	97	26	very	very	RB
cord-048322-5eqdrd52	97	27	high	high	JJ
cord-048322-5eqdrd52	97	28	N	n	CD
cord-048322-5eqdrd52	97	29	/	/	SYM
cord-048322-5eqdrd52	97	30	P	p	NN
cord-048322-5eqdrd52	97	31	ratios	ratio	NNS
cord-048322-5eqdrd52	97	32	which	which	WDT
cord-048322-5eqdrd52	97	33	may	may	MD
cord-048322-5eqdrd52	97	34	be	be	VB
cord-048322-5eqdrd52	97	35	attributed	attribute	VBN
cord-048322-5eqdrd52	97	36	to	to	IN
cord-048322-5eqdrd52	97	37	the	the	DT
cord-048322-5eqdrd52	97	38	fact	fact	NN
cord-048322-5eqdrd52	97	39	that	that	IN
cord-048322-5eqdrd52	97	40	a	a	DT
cord-048322-5eqdrd52	97	41	decrease	decrease	NN
cord-048322-5eqdrd52	97	42	in	in	IN
cord-048322-5eqdrd52	97	43	the	the	DT
cord-048322-5eqdrd52	97	44	molecular	molecular	JJ
cord-048322-5eqdrd52	97	45	weight	weight	NN
cord-048322-5eqdrd52	97	46	of	of	IN
cord-048322-5eqdrd52	97	47	PEI	PEI	NNP
cord-048322-5eqdrd52	97	48	has	have	VBZ
cord-048322-5eqdrd52	97	49	been	be	VBN
cord-048322-5eqdrd52	97	50	shown	show	VBN
cord-048322-5eqdrd52	97	51	to	to	TO
cord-048322-5eqdrd52	97	52	translate	translate	VB
cord-048322-5eqdrd52	97	53	into	into	IN
cord-048322-5eqdrd52	97	54	an	an	DT
cord-048322-5eqdrd52	97	55	increasingly	increasingly	RB
cord-048322-5eqdrd52	97	56	lower	low	JJR
cord-048322-5eqdrd52	97	57	ability	ability	NN
cord-048322-5eqdrd52	97	58	to	to	TO
cord-048322-5eqdrd52	97	59	form	form	VB
cord-048322-5eqdrd52	97	60	small	small	JJ
cord-048322-5eqdrd52	97	61	complexes	complex	NNS
cord-048322-5eqdrd52	97	62	[	[	-LRB-
cord-048322-5eqdrd52	97	63	63	63	CD
cord-048322-5eqdrd52	97	64	]	]	-RRB-
cord-048322-5eqdrd52	97	65	.	.	.
cord-048322-5eqdrd52	98	1	Therefore	therefore	RB
cord-048322-5eqdrd52	98	2	,	,	,
cord-048322-5eqdrd52	98	3	low	low	JJ
cord-048322-5eqdrd52	98	4	molecular	molecular	JJ
cord-048322-5eqdrd52	98	5	weight	weight	NN
cord-048322-5eqdrd52	98	6	PEIs	pei	NNS
cord-048322-5eqdrd52	98	7	require	require	VBP
cord-048322-5eqdrd52	98	8	higher	high	JJR
cord-048322-5eqdrd52	98	9	N	n	NN
cord-048322-5eqdrd52	98	10	/	/	SYM
cord-048322-5eqdrd52	98	11	P	p	NN
cord-048322-5eqdrd52	98	12	ratios	ratio	NNS
cord-048322-5eqdrd52	98	13	for	for	IN
cord-048322-5eqdrd52	98	14	optimal	optimal	JJ
cord-048322-5eqdrd52	98	15	transfection	transfection	NN
cord-048322-5eqdrd52	98	16	efficacies	efficacy	NNS
cord-048322-5eqdrd52	98	17	as	as	IN
cord-048322-5eqdrd52	98	18	compared	compare	VBN
cord-048322-5eqdrd52	98	19	to	to	IN
cord-048322-5eqdrd52	98	20	higher	high	JJR
cord-048322-5eqdrd52	98	21	molecular	molecular	JJ
cord-048322-5eqdrd52	98	22	weight	weight	NN
cord-048322-5eqdrd52	98	23	PEIs	pei	NNS
cord-048322-5eqdrd52	98	24	since	since	IN
cord-048322-5eqdrd52	98	25	higher	high	JJR
cord-048322-5eqdrd52	98	26	N	n	NN
cord-048322-5eqdrd52	98	27	/	/	SYM
cord-048322-5eqdrd52	98	28	P	p	NN
cord-048322-5eqdrd52	98	29	ratios	ratio	NNS
cord-048322-5eqdrd52	98	30	lead	lead	VBP
cord-048322-5eqdrd52	98	31	to	to	IN
cord-048322-5eqdrd52	98	32	an	an	DT
cord-048322-5eqdrd52	98	33	increase	increase	NN
cord-048322-5eqdrd52	98	34	in	in	IN
cord-048322-5eqdrd52	98	35	compaction	compaction	NN
cord-048322-5eqdrd52	98	36	with	with	IN
cord-048322-5eqdrd52	98	37	reduced	reduce	VBN
cord-048322-5eqdrd52	98	38	complex	complex	JJ
cord-048322-5eqdrd52	98	39	sizes	size	NNS
cord-048322-5eqdrd52	98	40	and	and	CC
cord-048322-5eqdrd52	98	41	a	a	DT
cord-048322-5eqdrd52	98	42	reduced	reduce	VBN
cord-048322-5eqdrd52	98	43	tendency	tendency	NN
cord-048322-5eqdrd52	98	44	of	of	IN
cord-048322-5eqdrd52	98	45	the	the	DT
cord-048322-5eqdrd52	98	46	complexes	complex	NNS
cord-048322-5eqdrd52	98	47	to	to	TO
cord-048322-5eqdrd52	98	48	aggregate	aggregate	VB
cord-048322-5eqdrd52	98	49	due	due	IN
cord-048322-5eqdrd52	98	50	to	to	IN
cord-048322-5eqdrd52	98	51	hydrophobic	hydrophobic	JJ
cord-048322-5eqdrd52	98	52	interactions	interaction	NNS
cord-048322-5eqdrd52	98	53	[	[	-LRB-
cord-048322-5eqdrd52	98	54	61	61	CD
cord-048322-5eqdrd52	98	55	,	,	,
cord-048322-5eqdrd52	98	56	63	63	CD
cord-048322-5eqdrd52	98	57	,	,	,
cord-048322-5eqdrd52	98	58	64	64	CD
cord-048322-5eqdrd52	98	59	]	]	-RRB-
cord-048322-5eqdrd52	98	60	.	.	.
cord-048322-5eqdrd52	99	1	Nevertheless	nevertheless	RB
cord-048322-5eqdrd52	99	2	,	,	,
cord-048322-5eqdrd52	99	3	while	while	IN
cord-048322-5eqdrd52	99	4	several	several	JJ
cord-048322-5eqdrd52	99	5	parameters	parameter	NNS
cord-048322-5eqdrd52	99	6	have	have	VBP
cord-048322-5eqdrd52	99	7	been	be	VBN
cord-048322-5eqdrd52	99	8	extensively	extensively	RB
cord-048322-5eqdrd52	99	9	studied	study	VBN
cord-048322-5eqdrd52	99	10	,	,	,
cord-048322-5eqdrd52	99	11	some	some	DT
cord-048322-5eqdrd52	99	12	precise	precise	JJ
cord-048322-5eqdrd52	99	13	determinants	determinant	NNS
cord-048322-5eqdrd52	99	14	for	for	IN
cord-048322-5eqdrd52	99	15	transfection	transfection	NN
cord-048322-5eqdrd52	99	16	efficacy	efficacy	NN
cord-048322-5eqdrd52	99	17	remain	remain	VBP
cord-048322-5eqdrd52	99	18	to	to	TO
cord-048322-5eqdrd52	99	19	be	be	VB
cord-048322-5eqdrd52	99	20	elucidated	elucidate	VBN
cord-048322-5eqdrd52	99	21	(	(	-LRB-
cord-048322-5eqdrd52	99	22	see	see	VB
cord-048322-5eqdrd52	99	23	[	[	-LRB-
cord-048322-5eqdrd52	99	24	50	50	CD
cord-048322-5eqdrd52	99	25	,	,	,
cord-048322-5eqdrd52	99	26	66	66	CD
cord-048322-5eqdrd52	99	27	]	]	-RRB-
cord-048322-5eqdrd52	99	28	for	for	IN
cord-048322-5eqdrd52	99	29	review	review	NN
cord-048322-5eqdrd52	99	30	)	)	-RRB-
cord-048322-5eqdrd52	99	31	.	.	.
cord-048322-5eqdrd52	100	1	Also	also	RB
cord-048322-5eqdrd52	100	2	,	,	,
cord-048322-5eqdrd52	100	3	the	the	DT
cord-048322-5eqdrd52	100	4	mechanism	mechanism	NN
cord-048322-5eqdrd52	100	5	of	of	IN
cord-048322-5eqdrd52	100	6	the	the	DT
cord-048322-5eqdrd52	100	7	cytotoxic	cytotoxic	JJ
cord-048322-5eqdrd52	100	8	effects	effect	NNS
cord-048322-5eqdrd52	100	9	of	of	IN
cord-048322-5eqdrd52	100	10	PEI	PEI	NNP
cord-048322-5eqdrd52	100	11	complexes	complex	NNS
cord-048322-5eqdrd52	100	12	is	be	VBZ
cord-048322-5eqdrd52	100	13	only	only	RB
cord-048322-5eqdrd52	100	14	poorly	poorly	RB
cord-048322-5eqdrd52	100	15	understood	understand	VBN
cord-048322-5eqdrd52	100	16	.	.	.
cord-048322-5eqdrd52	101	1	It	-PRON-	PRP
cord-048322-5eqdrd52	101	2	may	may	MD
cord-048322-5eqdrd52	101	3	rely	rely	VB
cord-048322-5eqdrd52	101	4	on	on	IN
cord-048322-5eqdrd52	101	5	the	the	DT
cord-048322-5eqdrd52	101	6	formation	formation	NN
cord-048322-5eqdrd52	101	7	of	of	IN
cord-048322-5eqdrd52	101	8	large	large	JJ
cord-048322-5eqdrd52	101	9	aggregates	aggregate	NNS
cord-048322-5eqdrd52	101	10	in	in	IN
cord-048322-5eqdrd52	101	11	the	the	DT
cord-048322-5eqdrd52	101	12	range	range	NN
cord-048322-5eqdrd52	101	13	of	of	IN
cord-048322-5eqdrd52	101	14	up	up	IN
cord-048322-5eqdrd52	101	15	to	to	TO
cord-048322-5eqdrd52	101	16	2	2	CD
cord-048322-5eqdrd52	101	17	μm	μm	NN
cord-048322-5eqdrd52	101	18	which	which	WDT
cord-048322-5eqdrd52	101	19	,	,	,
cord-048322-5eqdrd52	101	20	when	when	WRB
cord-048322-5eqdrd52	101	21	formed	form	VBN
cord-048322-5eqdrd52	101	22	on	on	IN
cord-048322-5eqdrd52	101	23	the	the	DT
cord-048322-5eqdrd52	101	24	cell	cell	NN
cord-048322-5eqdrd52	101	25	surface	surface	NN
cord-048322-5eqdrd52	101	26	,	,	,
cord-048322-5eqdrd52	101	27	impairs	impair	VBZ
cord-048322-5eqdrd52	101	28	membrane	membrane	NN
cord-048322-5eqdrd52	101	29	functions	function	NNS
cord-048322-5eqdrd52	101	30	finally	finally	RB
cord-048322-5eqdrd52	101	31	leading	lead	VBG
cord-048322-5eqdrd52	101	32	to	to	IN
cord-048322-5eqdrd52	101	33	cell	cell	NN
cord-048322-5eqdrd52	101	34	necrosis	necrosis	NN
cord-048322-5eqdrd52	101	35	[	[	-LRB-
cord-048322-5eqdrd52	101	36	60	60	CD
cord-048322-5eqdrd52	101	37	]	]	-RRB-
cord-048322-5eqdrd52	101	38	.	.	.
cord-048322-5eqdrd52	102	1	Clearly	clearly	RB
cord-048322-5eqdrd52	102	2	,	,	,
cord-048322-5eqdrd52	102	3	there	there	EX
cord-048322-5eqdrd52	102	4	is	be	VBZ
cord-048322-5eqdrd52	102	5	a	a	DT
cord-048322-5eqdrd52	102	6	trend	trend	NN
cord-048322-5eqdrd52	102	7	towards	towards	IN
cord-048322-5eqdrd52	102	8	low	low	JJ
cord-048322-5eqdrd52	102	9	molecular	molecular	JJ
cord-048322-5eqdrd52	102	10	weight	weight	NN
cord-048322-5eqdrd52	102	11	PEIs	pei	NNS
cord-048322-5eqdrd52	102	12	as	as	IN
cord-048322-5eqdrd52	102	13	rather	rather	RB
cord-048322-5eqdrd52	102	14	nontoxic	nontoxic	JJ
cord-048322-5eqdrd52	102	15	delivery	delivery	NN
cord-048322-5eqdrd52	102	16	reagents	reagent	NNS
cord-048322-5eqdrd52	102	17	in	in	IN
cord-048322-5eqdrd52	102	18	vitro	vitro	FW
cord-048322-5eqdrd52	102	19	and	and	CC
cord-048322-5eqdrd52	102	20	in	in	IN
cord-048322-5eqdrd52	102	21	vivo	vivo	NNP
cord-048322-5eqdrd52	102	22	,	,	,
cord-048322-5eqdrd52	102	23	which	which	WDT
cord-048322-5eqdrd52	102	24	combine	combine	VBP
cord-048322-5eqdrd52	102	25	high	high	JJ
cord-048322-5eqdrd52	102	26	biocompatibility	biocompatibility	NN
cord-048322-5eqdrd52	102	27	and	and	CC
cord-048322-5eqdrd52	102	28	reduced	reduce	VBN
cord-048322-5eqdrd52	102	29	side	side	NN
cord-048322-5eqdrd52	102	30	-	-	HYPH
cord-048322-5eqdrd52	102	31	effects	effect	NNS
cord-048322-5eqdrd52	102	32	thus	thus	RB
cord-048322-5eqdrd52	102	33	also	also	RB
cord-048322-5eqdrd52	102	34	allowing	allow	VBG
cord-048322-5eqdrd52	102	35	to	to	TO
cord-048322-5eqdrd52	102	36	employ	employ	VB
cord-048322-5eqdrd52	102	37	larger	large	JJR
cord-048322-5eqdrd52	102	38	PEI	PEI	NNP
cord-048322-5eqdrd52	102	39	/	/	SYM
cord-048322-5eqdrd52	102	40	DNA	dna	NN
cord-048322-5eqdrd52	102	41	complex	complex	JJ
cord-048322-5eqdrd52	102	42	amounts	amount	NNS
cord-048322-5eqdrd52	102	43	without	without	IN
cord-048322-5eqdrd52	102	44	significant	significant	JJ
cord-048322-5eqdrd52	102	45	cytotoxicity	cytotoxicity	NN
cord-048322-5eqdrd52	102	46	.	.	.
cord-048322-5eqdrd52	103	1	More	more	RBR
cord-048322-5eqdrd52	103	2	recently	recently	RB
cord-048322-5eqdrd52	103	3	,	,	,
cord-048322-5eqdrd52	103	4	the	the	DT
cord-048322-5eqdrd52	103	5	use	use	NN
cord-048322-5eqdrd52	103	6	of	of	IN
cord-048322-5eqdrd52	103	7	polyethylenimines	polyethylenimine	NNS
cord-048322-5eqdrd52	103	8	has	have	VBZ
cord-048322-5eqdrd52	103	9	been	be	VBN
cord-048322-5eqdrd52	103	10	extended	extend	VBN
cord-048322-5eqdrd52	103	11	towards	towards	IN
cord-048322-5eqdrd52	103	12	the	the	DT
cord-048322-5eqdrd52	103	13	complexation	complexation	NN
cord-048322-5eqdrd52	103	14	and	and	CC
cord-048322-5eqdrd52	103	15	delivery	delivery	NN
cord-048322-5eqdrd52	103	16	of	of	IN
cord-048322-5eqdrd52	103	17	RNA	RNA	NNP
cord-048322-5eqdrd52	103	18	molecules	molecule	NNS
cord-048322-5eqdrd52	103	19	,	,	,
cord-048322-5eqdrd52	103	20	especially	especially	RB
cord-048322-5eqdrd52	103	21	small	small	JJ
cord-048322-5eqdrd52	103	22	RNA	RNA	NNP
cord-048322-5eqdrd52	103	23	molecules	molecule	NNS
cord-048322-5eqdrd52	103	24	like	like	IN
cord-048322-5eqdrd52	103	25	37	37	CD
cord-048322-5eqdrd52	103	26	nt	nt	RB
cord-048322-5eqdrd52	103	27	all	all	DT
cord-048322-5eqdrd52	103	28	-	-	HYPH
cord-048322-5eqdrd52	103	29	RNA	RNA	NNP
cord-048322-5eqdrd52	103	30	ribozymes	ribozyme	NNS
cord-048322-5eqdrd52	103	31	[	[	-LRB-
cord-048322-5eqdrd52	103	32	67	67	CD
cord-048322-5eqdrd52	103	33	]	]	-RRB-
cord-048322-5eqdrd52	104	1	[	[	-LRB-
cord-048322-5eqdrd52	104	2	68	68	CD
cord-048322-5eqdrd52	104	3	]	]	-RRB-
cord-048322-5eqdrd52	105	1	[	[	-LRB-
cord-048322-5eqdrd52	105	2	69	69	CD
cord-048322-5eqdrd52	105	3	]	]	-RRB-
cord-048322-5eqdrd52	105	4	and	and	CC
cord-048322-5eqdrd52	105	5	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	105	6	[	[	-LRB-
cord-048322-5eqdrd52	105	7	70	70	CD
cord-048322-5eqdrd52	105	8	]	]	-RRB-
cord-048322-5eqdrd52	106	1	(	(	-LRB-
cord-048322-5eqdrd52	106	2	Figure	figure	NN
cord-048322-5eqdrd52	106	3	2	2	CD
cord-048322-5eqdrd52	106	4	)	)	-RRB-
cord-048322-5eqdrd52	106	5	.	.	.
cord-048322-5eqdrd52	107	1	While	while	IN
cord-048322-5eqdrd52	107	2	chemically	chemically	RB
cord-048322-5eqdrd52	107	3	unmodified	unmodified	JJ
cord-048322-5eqdrd52	107	4	RNA	RNA	NNP
cord-048322-5eqdrd52	107	5	molecules	molecule	NNS
cord-048322-5eqdrd52	107	6	are	be	VBP
cord-048322-5eqdrd52	107	7	very	very	RB
cord-048322-5eqdrd52	107	8	instable	instable	JJ
cord-048322-5eqdrd52	107	9	and	and	CC
cord-048322-5eqdrd52	107	10	prone	prone	JJ
cord-048322-5eqdrd52	107	11	to	to	IN
cord-048322-5eqdrd52	107	12	rapid	rapid	JJ
cord-048322-5eqdrd52	107	13	degradation	degradation	NN
cord-048322-5eqdrd52	107	14	,	,	,
cord-048322-5eqdrd52	107	15	the	the	DT
cord-048322-5eqdrd52	107	16	PEI	PEI	NNP
cord-048322-5eqdrd52	107	17	complexation	complexation	NN
cord-048322-5eqdrd52	107	18	has	have	VBZ
cord-048322-5eqdrd52	107	19	been	be	VBN
cord-048322-5eqdrd52	107	20	shown	show	VBN
cord-048322-5eqdrd52	107	21	to	to	TO
cord-048322-5eqdrd52	107	22	lead	lead	VB
cord-048322-5eqdrd52	107	23	to	to	IN
cord-048322-5eqdrd52	107	24	an	an	DT
cord-048322-5eqdrd52	107	25	almost	almost	RB
cord-048322-5eqdrd52	107	26	complete	complete	JJ
cord-048322-5eqdrd52	107	27	protection	protection	NN
cord-048322-5eqdrd52	107	28	against	against	IN
cord-048322-5eqdrd52	107	29	enzymatic	enzymatic	JJ
cord-048322-5eqdrd52	107	30	or	or	CC
cord-048322-5eqdrd52	107	31	nonenzymatic	nonenzymatic	JJ
cord-048322-5eqdrd52	107	32	degradation	degradation	NN
cord-048322-5eqdrd52	107	33	.	.	.
cord-048322-5eqdrd52	108	1	In	in	IN
cord-048322-5eqdrd52	108	2	fact	fact	NN
cord-048322-5eqdrd52	108	3	,	,	,
cord-048322-5eqdrd52	108	4	PEI	PEI	NNP
cord-048322-5eqdrd52	108	5	-	-	HYPH
cord-048322-5eqdrd52	108	6	complexed	complexe	VBN
cord-048322-5eqdrd52	108	7	siR	siR	NNP
cord-048322-5eqdrd52	108	8	-	-	HYPH
cord-048322-5eqdrd52	108	9	NAs	NAs	NNPS
cord-048322-5eqdrd52	108	10	,	,	,
cord-048322-5eqdrd52	108	11	which	which	WDT
cord-048322-5eqdrd52	108	12	are	be	VBP
cord-048322-5eqdrd52	108	13	[	[	-LRB-
cord-048322-5eqdrd52	108	14	32	32	CD
cord-048322-5eqdrd52	108	15	P]-labeled	p]-labele	VBN
cord-048322-5eqdrd52	108	16	for	for	IN
cord-048322-5eqdrd52	108	17	better	well	JJR
cord-048322-5eqdrd52	108	18	detection	detection	NN
cord-048322-5eqdrd52	108	19	,	,	,
cord-048322-5eqdrd52	108	20	remain	remain	VBP
cord-048322-5eqdrd52	108	21	intact	intact	JJ
cord-048322-5eqdrd52	108	22	in	in	IN
cord-048322-5eqdrd52	108	23	vitro	vitro	FW
cord-048322-5eqdrd52	108	24	for	for	IN
cord-048322-5eqdrd52	108	25	several	several	JJ
cord-048322-5eqdrd52	108	26	hours	hour	NNS
cord-048322-5eqdrd52	108	27	even	even	RB
cord-048322-5eqdrd52	108	28	in	in	IN
cord-048322-5eqdrd52	108	29	the	the	DT
cord-048322-5eqdrd52	108	30	presence	presence	NN
cord-048322-5eqdrd52	108	31	of	of	IN
cord-048322-5eqdrd52	108	32	RNase	RNase	NNP
cord-048322-5eqdrd52	108	33	A	A	NNP
cord-048322-5eqdrd52	108	34	or	or	CC
cord-048322-5eqdrd52	108	35	fetal	fetal	JJ
cord-048322-5eqdrd52	108	36	calf	calf	NN
cord-048322-5eqdrd52	108	37	serum	serum	NN
cord-048322-5eqdrd52	108	38	at	at	IN
cord-048322-5eqdrd52	108	39	37	37	CD
cord-048322-5eqdrd52	109	1	•	•	NNP
cord-048322-5eqdrd52	109	2	C	C	NNP
cord-048322-5eqdrd52	109	3	,	,	,
cord-048322-5eqdrd52	109	4	while	while	IN
cord-048322-5eqdrd52	109	5	non	non	JJ
cord-048322-5eqdrd52	109	6	-	-	JJ
cord-048322-5eqdrd52	109	7	complexed	complexed	JJ
cord-048322-5eqdrd52	109	8	siRNAs	sirna	NNS
cord-048322-5eqdrd52	109	9	are	be	VBP
cord-048322-5eqdrd52	109	10	rapidly	rapidly	RB
cord-048322-5eqdrd52	109	11	degraded	degrade	VBN
cord-048322-5eqdrd52	109	12	(	(	-LRB-
cord-048322-5eqdrd52	109	13	Figure	figure	NN
cord-048322-5eqdrd52	109	14	3(a	3(a	CD
cord-048322-5eqdrd52	109	15	)	)	-RRB-
cord-048322-5eqdrd52	109	16	)	)	-RRB-
cord-048322-5eqdrd52	109	17	.	.	.
cord-048322-5eqdrd52	110	1	This	this	DT
cord-048322-5eqdrd52	110	2	indicates	indicate	VBZ
cord-048322-5eqdrd52	110	3	that	that	IN
cord-048322-5eqdrd52	110	4	siRNA	siRNA	NNP
cord-048322-5eqdrd52	110	5	molecules	molecule	NNS
cord-048322-5eqdrd52	110	6	are	be	VBP
cord-048322-5eqdrd52	110	7	efficiently	efficiently	RB
cord-048322-5eqdrd52	110	8	condensed	condense	VBN
cord-048322-5eqdrd52	110	9	and	and	CC
cord-048322-5eqdrd52	110	10	thus	thus	RB
cord-048322-5eqdrd52	110	11	fully	fully	RB
cord-048322-5eqdrd52	110	12	covered	cover	VBN
cord-048322-5eqdrd52	110	13	and	and	CC
cord-048322-5eqdrd52	110	14	protected	protect	VBN
cord-048322-5eqdrd52	110	15	by	by	IN
cord-048322-5eqdrd52	110	16	PEI	PEI	NNP
cord-048322-5eqdrd52	110	17	.	.	.
cord-048322-5eqdrd52	111	1	Indeed	indeed	RB
cord-048322-5eqdrd52	111	2	,	,	,
cord-048322-5eqdrd52	111	3	the	the	DT
cord-048322-5eqdrd52	111	4	analysis	analysis	NN
cord-048322-5eqdrd52	111	5	of	of	IN
cord-048322-5eqdrd52	111	6	PEI	PEI	NNP
cord-048322-5eqdrd52	111	7	/	/	SYM
cord-048322-5eqdrd52	111	8	siRNA	siRNA	NNP
cord-048322-5eqdrd52	111	9	complexes	complex	NNS
cord-048322-5eqdrd52	111	10	by	by	IN
cord-048322-5eqdrd52	111	11	atomic	atomic	JJ
cord-048322-5eqdrd52	111	12	force	force	NN
cord-048322-5eqdrd52	111	13	microscopy	microscopy	NNS
cord-048322-5eqdrd52	111	14	showed	show	VBD
cord-048322-5eqdrd52	111	15	the	the	DT
cord-048322-5eqdrd52	111	16	absence	absence	NN
cord-048322-5eqdrd52	111	17	of	of	IN
cord-048322-5eqdrd52	111	18	free	free	JJ
cord-048322-5eqdrd52	111	19	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	111	20	or	or	CC
cord-048322-5eqdrd52	111	21	siRNA	siRNA	NNP
cord-048322-5eqdrd52	111	22	molecule	molecule	NN
cord-048322-5eqdrd52	111	23	ends	end	VBZ
cord-048322-5eqdrd52	111	24	and	and	CC
cord-048322-5eqdrd52	111	25	thus	thus	RB
cord-048322-5eqdrd52	111	26	confirms	confirm	VBZ
cord-048322-5eqdrd52	111	27	these	these	DT
cord-048322-5eqdrd52	111	28	findings	finding	NNS
cord-048322-5eqdrd52	111	29	regarding	regard	VBG
cord-048322-5eqdrd52	111	30	an	an	DT
cord-048322-5eqdrd52	111	31	efficient	efficient	JJ
cord-048322-5eqdrd52	111	32	complexation	complexation	NN
cord-048322-5eqdrd52	111	33	(	(	-LRB-
cord-048322-5eqdrd52	111	34	Grzelinski	Grzelinski	NNP
cord-048322-5eqdrd52	111	35	et	et	NNP
cord-048322-5eqdrd52	111	36	al	al	NNP
cord-048322-5eqdrd52	111	37	,	,	,
cord-048322-5eqdrd52	111	38	submitted	submit	VBD
cord-048322-5eqdrd52	111	39	)	)	-RRB-
cord-048322-5eqdrd52	111	40	.	.	.
cord-048322-5eqdrd52	112	1	However	however	RB
cord-048322-5eqdrd52	112	2	,	,	,
cord-048322-5eqdrd52	112	3	while	while	IN
cord-048322-5eqdrd52	112	4	the	the	DT
cord-048322-5eqdrd52	112	5	complex	complex	JJ
cord-048322-5eqdrd52	112	6	stability	stability	NN
cord-048322-5eqdrd52	112	7	seems	seem	VBZ
cord-048322-5eqdrd52	112	8	to	to	TO
cord-048322-5eqdrd52	112	9	be	be	VB
cord-048322-5eqdrd52	112	10	sufficient	sufficient	JJ
cord-048322-5eqdrd52	112	11	for	for	IN
cord-048322-5eqdrd52	112	12	siRNA	siRNA	NNP
cord-048322-5eqdrd52	112	13	protection	protection	NN
cord-048322-5eqdrd52	112	14	with	with	IN
cord-048322-5eqdrd52	112	15	all	all	DT
cord-048322-5eqdrd52	112	16	PEIs	pei	NNS
cord-048322-5eqdrd52	112	17	tested	test	VBN
cord-048322-5eqdrd52	112	18	(	(	-LRB-
cord-048322-5eqdrd52	112	19	Werth	Werth	NNP
cord-048322-5eqdrd52	112	20	et	et	NNP
cord-048322-5eqdrd52	112	21	al	al	NNP
cord-048322-5eqdrd52	112	22	,	,	,
cord-048322-5eqdrd52	112	23	in	in	IN
cord-048322-5eqdrd52	112	24	press	press	NN
cord-048322-5eqdrd52	112	25	;	;	:
cord-048322-5eqdrd52	112	26	Aigner	Aigner	NNP
cord-048322-5eqdrd52	112	27	et	et	NNP
cord-048322-5eqdrd52	112	28	al	al	NNP
cord-048322-5eqdrd52	112	29	,	,	,
cord-048322-5eqdrd52	112	30	unpublished	unpublished	JJ
cord-048322-5eqdrd52	112	31	data	datum	NNS
cord-048322-5eqdrd52	112	32	)	)	-RRB-
cord-048322-5eqdrd52	112	33	,	,	,
cord-048322-5eqdrd52	112	34	several	several	JJ
cord-048322-5eqdrd52	112	35	of	of	IN
cord-048322-5eqdrd52	112	36	these	these	DT
cord-048322-5eqdrd52	112	37	complexes	complex	NNS
cord-048322-5eqdrd52	112	38	do	do	VBP
cord-048322-5eqdrd52	112	39	not	not	RB
cord-048322-5eqdrd52	112	40	show	show	VB
cord-048322-5eqdrd52	112	41	any	any	DT
cord-048322-5eqdrd52	112	42	targeting	target	VBG
cord-048322-5eqdrd52	112	43	efficacy	efficacy	NN
cord-048322-5eqdrd52	112	44	at	at	RB
cord-048322-5eqdrd52	112	45	all	all	RB
cord-048322-5eqdrd52	112	46	.	.	.
cord-048322-5eqdrd52	113	1	In	in	IN
cord-048322-5eqdrd52	113	2	fact	fact	NN
cord-048322-5eqdrd52	113	3	,	,	,
cord-048322-5eqdrd52	113	4	only	only	RB
cord-048322-5eqdrd52	113	5	when	when	WRB
cord-048322-5eqdrd52	113	6	using	use	VBG
cord-048322-5eqdrd52	113	7	certain	certain	JJ
cord-048322-5eqdrd52	113	8	polyethylenimines	polyethylenimine	NNS
cord-048322-5eqdrd52	113	9	,	,	,
cord-048322-5eqdrd52	113	10	PEI	PEI	NNP
cord-048322-5eqdrd52	113	11	/	/	SYM
cord-048322-5eqdrd52	113	12	siRNA	siRNA	NNP
cord-048322-5eqdrd52	113	13	complexes	complex	NNS
cord-048322-5eqdrd52	113	14	are	be	VBP
cord-048322-5eqdrd52	113	15	efficiently	efficiently	RB
cord-048322-5eqdrd52	113	16	delivered	deliver	VBN
cord-048322-5eqdrd52	113	17	into	into	IN
cord-048322-5eqdrd52	113	18	target	target	NN
cord-048322-5eqdrd52	113	19	cells	cell	NNS
cord-048322-5eqdrd52	113	20	in	in	IN
cord-048322-5eqdrd52	113	21	vitro	vitro	FW
cord-048322-5eqdrd52	113	22	,	,	,
cord-048322-5eqdrd52	113	23	where	where	WRB
cord-048322-5eqdrd52	113	24	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	113	25	are	be	VBP
cord-048322-5eqdrd52	113	26	released	release	VBN
cord-048322-5eqdrd52	113	27	and	and	CC
cord-048322-5eqdrd52	113	28	display	display	NN
cord-048322-5eqdrd52	113	29	bioactivity	bioactivity	NN
cord-048322-5eqdrd52	113	30	(	(	-LRB-
cord-048322-5eqdrd52	113	31	Figures	figure	NNS
cord-048322-5eqdrd52	113	32	1	1	CD
cord-048322-5eqdrd52	113	33	and	and	CC
cord-048322-5eqdrd52	113	34	2	2	CD
cord-048322-5eqdrd52	113	35	)	)	-RRB-
cord-048322-5eqdrd52	113	36	.	.	.
cord-048322-5eqdrd52	114	1	In	in	IN
cord-048322-5eqdrd52	114	2	general	general	JJ
cord-048322-5eqdrd52	114	3	and	and	CC
cord-048322-5eqdrd52	114	4	as	as	IN
cord-048322-5eqdrd52	114	5	seen	see	VBN
cord-048322-5eqdrd52	114	6	before	before	RB
cord-048322-5eqdrd52	114	7	for	for	IN
cord-048322-5eqdrd52	114	8	PEI	PEI	NNP
cord-048322-5eqdrd52	114	9	/	/	SYM
cord-048322-5eqdrd52	114	10	DNA	dna	NN
cord-048322-5eqdrd52	114	11	complexes	complex	NNS
cord-048322-5eqdrd52	114	12	(	(	-LRB-
cord-048322-5eqdrd52	114	13	see	see	VB
cord-048322-5eqdrd52	114	14	above	above	RB
cord-048322-5eqdrd52	114	15	)	)	-RRB-
cord-048322-5eqdrd52	114	16	,	,	,
cord-048322-5eqdrd52	114	17	the	the	DT
cord-048322-5eqdrd52	114	18	transfection	transfection	NN
cord-048322-5eqdrd52	114	19	efficacy	efficacy	NN
cord-048322-5eqdrd52	114	20	is	be	VBZ
cord-048322-5eqdrd52	114	21	dependent	dependent	JJ
cord-048322-5eqdrd52	114	22	on	on	IN
cord-048322-5eqdrd52	114	23	the	the	DT
cord-048322-5eqdrd52	114	24	PEI	PEI	NNP
cord-048322-5eqdrd52	114	25	used	use	VBD
cord-048322-5eqdrd52	114	26	,	,	,
cord-048322-5eqdrd52	114	27	also	also	RB
cord-048322-5eqdrd52	114	28	indicating	indicate	VBG
cord-048322-5eqdrd52	114	29	that	that	IN
cord-048322-5eqdrd52	114	30	the	the	DT
cord-048322-5eqdrd52	114	31	siRNA	siRNA	NNP
cord-048322-5eqdrd52	114	32	targeting	target	VBG
cord-048322-5eqdrd52	114	33	efficiency	efficiency	NN
cord-048322-5eqdrd52	114	34	mainly	mainly	RB
cord-048322-5eqdrd52	114	35	depends	depend	VBZ
cord-048322-5eqdrd52	114	36	on	on	IN
cord-048322-5eqdrd52	114	37	the	the	DT
cord-048322-5eqdrd52	114	38	endocytotic	endocytotic	JJ
cord-048322-5eqdrd52	114	39	uptake	uptake	NN
cord-048322-5eqdrd52	114	40	of	of	IN
cord-048322-5eqdrd52	114	41	the	the	DT
cord-048322-5eqdrd52	114	42	complex	complex	NN
cord-048322-5eqdrd52	115	1	and/or	and/or	CC
cord-048322-5eqdrd52	115	2	its	-PRON-	PRP$
cord-048322-5eqdrd52	115	3	intracellular	intracellular	JJ
cord-048322-5eqdrd52	115	4	decomposition	decomposition	NN
cord-048322-5eqdrd52	115	5	rather	rather	RB
cord-048322-5eqdrd52	115	6	than	than	IN
cord-048322-5eqdrd52	115	7	on	on	IN
cord-048322-5eqdrd52	115	8	the	the	DT
cord-048322-5eqdrd52	115	9	in	in	FW
cord-048322-5eqdrd52	115	10	vitro	vitro	FW
cord-048322-5eqdrd52	115	11	complex	complex	JJ
cord-048322-5eqdrd52	115	12	stability	stability	NN
cord-048322-5eqdrd52	115	13	.	.	.
cord-048322-5eqdrd52	116	1	Good	good	JJ
cord-048322-5eqdrd52	116	2	results	result	NNS
cord-048322-5eqdrd52	116	3	were	be	VBD
cord-048322-5eqdrd52	116	4	obtained	obtain	VBN
cord-048322-5eqdrd52	116	5	with	with	IN
cord-048322-5eqdrd52	116	6	commercially	commercially	RB
cord-048322-5eqdrd52	116	7	available	available	JJ
cord-048322-5eqdrd52	116	8	JetPEI	JetPEI	NNS
cord-048322-5eqdrd52	116	9	[	[	-LRB-
cord-048322-5eqdrd52	116	10	70	70	CD
cord-048322-5eqdrd52	116	11	]	]	-RRB-
cord-048322-5eqdrd52	116	12	while	while	IN
cord-048322-5eqdrd52	116	13	the	the	DT
cord-048322-5eqdrd52	116	14	in	in	IN
cord-048322-5eqdrd52	116	15	vivo	vivo	FW
cord-048322-5eqdrd52	116	16	JetPEI	jetpei	FW
cord-048322-5eqdrd52	116	17	from	from	IN
cord-048322-5eqdrd52	116	18	the	the	DT
cord-048322-5eqdrd52	116	19	same	same	JJ
cord-048322-5eqdrd52	116	20	supplier	supplier	NN
cord-048322-5eqdrd52	116	21	showed	show	VBD
cord-048322-5eqdrd52	116	22	only	only	RB
cord-048322-5eqdrd52	116	23	poor	poor	JJ
cord-048322-5eqdrd52	116	24	siRNA	siRNA	NNP
cord-048322-5eqdrd52	116	25	delivery	delivery	NN
cord-048322-5eqdrd52	116	26	efficacies	efficacy	NNS
cord-048322-5eqdrd52	116	27	[	[	-LRB-
cord-048322-5eqdrd52	116	28	71	71	CD
cord-048322-5eqdrd52	116	29	]	]	-RRB-
cord-048322-5eqdrd52	116	30	.	.	.
cord-048322-5eqdrd52	117	1	Likewise	likewise	RB
cord-048322-5eqdrd52	117	2	,	,	,
cord-048322-5eqdrd52	117	3	a	a	DT
cord-048322-5eqdrd52	117	4	novel	novel	JJ
cord-048322-5eqdrd52	117	5	low	low	JJ
cord-048322-5eqdrd52	117	6	molecular	molecular	JJ
cord-048322-5eqdrd52	117	7	weight	weight	NN
cord-048322-5eqdrd52	117	8	PEI	PEI	NNP
cord-048322-5eqdrd52	117	9	based	base	VBN
cord-048322-5eqdrd52	117	10	on	on	IN
cord-048322-5eqdrd52	117	11	the	the	DT
cord-048322-5eqdrd52	117	12	fractionation	fractionation	NN
cord-048322-5eqdrd52	117	13	of	of	IN
cord-048322-5eqdrd52	117	14	a	a	DT
cord-048322-5eqdrd52	117	15	commercially	commercially	RB
cord-048322-5eqdrd52	117	16	available	available	JJ
cord-048322-5eqdrd52	117	17	polyethylenimine	polyethylenimine	NN
cord-048322-5eqdrd52	117	18	demonstrates	demonstrate	VBZ
cord-048322-5eqdrd52	117	19	high	high	JJ
cord-048322-5eqdrd52	117	20	siRNA	siRNA	NNP
cord-048322-5eqdrd52	117	21	protection	protection	NN
cord-048322-5eqdrd52	117	22	and	and	CC
cord-048322-5eqdrd52	117	23	delivery	delivery	NN
cord-048322-5eqdrd52	117	24	efficacies	efficacy	NNS
cord-048322-5eqdrd52	117	25	in	in	IN
cord-048322-5eqdrd52	117	26	vitro	vitro	FW
cord-048322-5eqdrd52	118	1	(	(	-LRB-
cord-048322-5eqdrd52	118	2	Werth	Werth	NNP
cord-048322-5eqdrd52	118	3	et	et	NNP
cord-048322-5eqdrd52	118	4	al	al	NNP
cord-048322-5eqdrd52	118	5	,	,	,
cord-048322-5eqdrd52	118	6	in	in	IN
cord-048322-5eqdrd52	118	7	press	press	NN
cord-048322-5eqdrd52	118	8	)	)	-RRB-
cord-048322-5eqdrd52	118	9	.	.	.
cord-048322-5eqdrd52	119	1	Under	under	IN
cord-048322-5eqdrd52	119	2	certain	certain	JJ
cord-048322-5eqdrd52	119	3	conditions	condition	NNS
cord-048322-5eqdrd52	119	4	,	,	,
cord-048322-5eqdrd52	119	5	the	the	DT
cord-048322-5eqdrd52	119	6	PEI	PEI	NNP
cord-048322-5eqdrd52	119	7	/	/	SYM
cord-048322-5eqdrd52	119	8	RNA	RNA	NNP
cord-048322-5eqdrd52	119	9	(	(	-LRB-
cord-048322-5eqdrd52	119	10	siRNA	siRNA	NNP
cord-048322-5eqdrd52	119	11	or	or	CC
cord-048322-5eqdrd52	119	12	ribozyme	ribozyme	NNP
cord-048322-5eqdrd52	119	13	)	)	-RRB-
cord-048322-5eqdrd52	119	14	complexes	complex	NNS
cord-048322-5eqdrd52	119	15	retain	retain	VBP
cord-048322-5eqdrd52	119	16	their	-PRON-	PRP$
cord-048322-5eqdrd52	119	17	physical	physical	JJ
cord-048322-5eqdrd52	119	18	stability	stability	NN
cord-048322-5eqdrd52	119	19	and	and	CC
cord-048322-5eqdrd52	119	20	biological	biological	JJ
cord-048322-5eqdrd52	119	21	activity	activity	NN
cord-048322-5eqdrd52	119	22	also	also	RB
cord-048322-5eqdrd52	119	23	after	after	IN
cord-048322-5eqdrd52	119	24	lyophilization	lyophilization	NN
cord-048322-5eqdrd52	119	25	(	(	-LRB-
cord-048322-5eqdrd52	119	26	[	[	-LRB-
cord-048322-5eqdrd52	119	27	72	72	CD
cord-048322-5eqdrd52	119	28	]	]	-RRB-
cord-048322-5eqdrd52	119	29	and	and	CC
cord-048322-5eqdrd52	119	30	Werth	Werth	NNP
cord-048322-5eqdrd52	119	31	et	et	NNP
cord-048322-5eqdrd52	119	32	al	al	NNP
cord-048322-5eqdrd52	119	33	,	,	,
cord-048322-5eqdrd52	119	34	in	in	IN
cord-048322-5eqdrd52	119	35	press	press	NN
cord-048322-5eqdrd52	119	36	)	)	-RRB-
cord-048322-5eqdrd52	119	37	.	.	.
cord-048322-5eqdrd52	120	1	Although	although	IN
cord-048322-5eqdrd52	120	2	the	the	DT
cord-048322-5eqdrd52	120	3	PEI	PEI	NNP
cord-048322-5eqdrd52	120	4	transfection	transfection	NN
cord-048322-5eqdrd52	120	5	is	be	VBZ
cord-048322-5eqdrd52	120	6	only	only	RB
cord-048322-5eqdrd52	120	7	transient	transient	JJ
cord-048322-5eqdrd52	120	8	,	,	,
cord-048322-5eqdrd52	120	9	data	datum	NNS
cord-048322-5eqdrd52	120	10	from	from	IN
cord-048322-5eqdrd52	120	11	our	-PRON-	PRP$
cord-048322-5eqdrd52	120	12	lab	lab	NN
cord-048322-5eqdrd52	120	13	show	show	NN
cord-048322-5eqdrd52	120	14	that	that	IN
cord-048322-5eqdrd52	120	15	PEI	PEI	NNP
cord-048322-5eqdrd52	120	16	/	/	SYM
cord-048322-5eqdrd52	120	17	siRNA	sirna	CD
cord-048322-5eqdrd52	120	18	effects	effect	NNS
cord-048322-5eqdrd52	120	19	are	be	VBP
cord-048322-5eqdrd52	120	20	stable	stable	JJ
cord-048322-5eqdrd52	120	21	for	for	IN
cord-048322-5eqdrd52	120	22	at	at	RB
cord-048322-5eqdrd52	120	23	least	least	JJS
cord-048322-5eqdrd52	120	24	7	7	CD
cord-048322-5eqdrd52	120	25	days	day	NNS
cord-048322-5eqdrd52	120	26	(	(	-LRB-
cord-048322-5eqdrd52	120	27	Urban	Urban	NNP
cord-048322-5eqdrd52	120	28	-	-	HYPH
cord-048322-5eqdrd52	120	29	Klein	Klein	NNP
cord-048322-5eqdrd52	120	30	and	and	CC
cord-048322-5eqdrd52	120	31	Aigner	Aigner	NNP
cord-048322-5eqdrd52	120	32	,	,	,
cord-048322-5eqdrd52	120	33	unpublished	unpublished	JJ
cord-048322-5eqdrd52	120	34	results	result	NNS
cord-048322-5eqdrd52	120	35	)	)	-RRB-
cord-048322-5eqdrd52	120	36	.	.	.
cord-048322-5eqdrd52	121	1	Finally	finally	RB
cord-048322-5eqdrd52	121	2	,	,	,
cord-048322-5eqdrd52	121	3	another	another	DT
cord-048322-5eqdrd52	121	4	study	study	NN
cord-048322-5eqdrd52	121	5	has	have	VBZ
cord-048322-5eqdrd52	121	6	explored	explore	VBN
cord-048322-5eqdrd52	121	7	the	the	DT
cord-048322-5eqdrd52	121	8	use	use	NN
cord-048322-5eqdrd52	121	9	of	of	IN
cord-048322-5eqdrd52	121	10	siRNA	siRNA	NNP
cord-048322-5eqdrd52	121	11	nanoplexes	nanoplexes	NNP
cord-048322-5eqdrd52	121	12	comprising	comprise	VBG
cord-048322-5eqdrd52	121	13	of	of	IN
cord-048322-5eqdrd52	121	14	PEI	PEI	NNP
cord-048322-5eqdrd52	121	15	that	that	WDT
cord-048322-5eqdrd52	121	16	is	be	VBZ
cord-048322-5eqdrd52	121	17	PEGylated	pegylate	VBN
cord-048322-5eqdrd52	121	18	with	with	IN
cord-048322-5eqdrd52	121	19	an	an	DT
cord-048322-5eqdrd52	121	20	RGD	RGD	NNP
cord-048322-5eqdrd52	121	21	peptide	peptide	NN
cord-048322-5eqdrd52	121	22	ligand	ligand	NN
cord-048322-5eqdrd52	121	23	attached	attach	VBN
cord-048322-5eqdrd52	121	24	at	at	IN
cord-048322-5eqdrd52	121	25	the	the	DT
cord-048322-5eqdrd52	121	26	distal	distal	JJ
cord-048322-5eqdrd52	121	27	end	end	NN
cord-048322-5eqdrd52	121	28	of	of	IN
cord-048322-5eqdrd52	121	29	the	the	DT
cord-048322-5eqdrd52	121	30	PEI	PEI	NNP
cord-048322-5eqdrd52	121	31	.	.	.
cord-048322-5eqdrd52	122	1	Again	again	RB
cord-048322-5eqdrd52	122	2	,	,	,
cord-048322-5eqdrd52	122	3	siRNA	siRNA	NNP
cord-048322-5eqdrd52	122	4	nanoplexes	nanoplexes	NNP
cord-048322-5eqdrd52	122	5	protect	protect	VBP
cord-048322-5eqdrd52	122	6	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	122	7	against	against	IN
cord-048322-5eqdrd52	122	8	serum	serum	NN
cord-048322-5eqdrd52	122	9	degradation	degradation	NN
cord-048322-5eqdrd52	122	10	and	and	CC
cord-048322-5eqdrd52	122	11	show	show	VB
cord-048322-5eqdrd52	122	12	in	in	IN
cord-048322-5eqdrd52	122	13	vitro	vitro	FW
cord-048322-5eqdrd52	122	14	activity	activity	NN
cord-048322-5eqdrd52	122	15	[	[	-LRB-
cord-048322-5eqdrd52	122	16	73	73	CD
cord-048322-5eqdrd52	122	17	]	]	-RRB-
cord-048322-5eqdrd52	122	18	.	.	.
cord-048322-5eqdrd52	123	1	The	the	DT
cord-048322-5eqdrd52	123	2	ultimate	ultimate	JJ
cord-048322-5eqdrd52	123	3	goal	goal	NN
cord-048322-5eqdrd52	123	4	is	be	VBZ
cord-048322-5eqdrd52	123	5	the	the	DT
cord-048322-5eqdrd52	123	6	application	application	NN
cord-048322-5eqdrd52	123	7	of	of	IN
cord-048322-5eqdrd52	123	8	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	123	9	in	in	IN
cord-048322-5eqdrd52	123	10	vivo	vivo	NN
cord-048322-5eqdrd52	123	11	which	which	WDT
cord-048322-5eqdrd52	123	12	has	have	VBZ
cord-048322-5eqdrd52	123	13	been	be	VBN
cord-048322-5eqdrd52	123	14	explored	explore	VBN
cord-048322-5eqdrd52	123	15	in	in	IN
cord-048322-5eqdrd52	123	16	some	some	DT
cord-048322-5eqdrd52	123	17	studies	study	NNS
cord-048322-5eqdrd52	123	18	in	in	IN
cord-048322-5eqdrd52	123	19	different	different	JJ
cord-048322-5eqdrd52	123	20	mouse	mouse	NN
cord-048322-5eqdrd52	123	21	models	model	NNS
cord-048322-5eqdrd52	123	22	.	.	.
cord-048322-5eqdrd52	124	1	Ge	Ge	NNP
cord-048322-5eqdrd52	124	2	et	et	NNP
cord-048322-5eqdrd52	124	3	al	al	NNP
cord-048322-5eqdrd52	124	4	showed	show	VBD
cord-048322-5eqdrd52	124	5	that	that	IN
cord-048322-5eqdrd52	124	6	PEI	PEI	NNP
cord-048322-5eqdrd52	124	7	-	-	HYPH
cord-048322-5eqdrd52	124	8	complexed	complexe	VBN
cord-048322-5eqdrd52	124	9	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	124	10	targeting	target	VBG
cord-048322-5eqdrd52	124	11	conserved	conserved	JJ
cord-048322-5eqdrd52	124	12	regions	region	NNS
cord-048322-5eqdrd52	124	13	of	of	IN
cord-048322-5eqdrd52	124	14	influenza	influenza	NN
cord-048322-5eqdrd52	124	15	virus	virus	NN
cord-048322-5eqdrd52	124	16	genes	gene	NNS
cord-048322-5eqdrd52	124	17	are	be	VBP
cord-048322-5eqdrd52	124	18	able	able	JJ
cord-048322-5eqdrd52	124	19	to	to	TO
cord-048322-5eqdrd52	124	20	prevent	prevent	VB
cord-048322-5eqdrd52	124	21	and	and	CC
cord-048322-5eqdrd52	124	22	treat	treat	VB
cord-048322-5eqdrd52	124	23	influenza	influenza	NN
cord-048322-5eqdrd52	124	24	virus	virus	NN
cord-048322-5eqdrd52	124	25	infection	infection	NN
cord-048322-5eqdrd52	124	26	in	in	IN
cord-048322-5eqdrd52	124	27	mice	mouse	NNS
cord-048322-5eqdrd52	124	28	.	.	.
cord-048322-5eqdrd52	125	1	Upon	upon	IN
cord-048322-5eqdrd52	125	2	IV	IV	NNP
cord-048322-5eqdrd52	125	3	injection	injection	NN
cord-048322-5eqdrd52	125	4	,	,	,
cord-048322-5eqdrd52	125	5	PEI	PEI	NNP
cord-048322-5eqdrd52	125	6	promoted	promote	VBD
cord-048322-5eqdrd52	125	7	the	the	DT
cord-048322-5eqdrd52	125	8	delivery	delivery	NN
cord-048322-5eqdrd52	125	9	of	of	IN
cord-048322-5eqdrd52	125	10	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	125	11	into	into	IN
cord-048322-5eqdrd52	125	12	the	the	DT
cord-048322-5eqdrd52	125	13	lungs	lung	NNS
cord-048322-5eqdrd52	125	14	where	where	WRB
cord-048322-5eqdrd52	125	15	,	,	,
cord-048322-5eqdrd52	125	16	either	either	CC
cord-048322-5eqdrd52	125	17	given	give	VBN
cord-048322-5eqdrd52	125	18	before	before	IN
cord-048322-5eqdrd52	125	19	or	or	CC
cord-048322-5eqdrd52	125	20	after	after	IN
cord-048322-5eqdrd52	125	21	virus	virus	NN
cord-048322-5eqdrd52	125	22	infection	infection	NN
cord-048322-5eqdrd52	125	23	,	,	,
cord-048322-5eqdrd52	125	24	siRNA	siRNA	NNP
cord-048322-5eqdrd52	125	25	reduced	reduce	VBN
cord-048322-5eqdrd52	125	26	influenza	influenza	NN
cord-048322-5eqdrd52	125	27	virus	virus	NN
cord-048322-5eqdrd52	125	28	production	production	NN
cord-048322-5eqdrd52	125	29	in	in	IN
cord-048322-5eqdrd52	125	30	the	the	DT
cord-048322-5eqdrd52	125	31	lungs	lung	NNS
cord-048322-5eqdrd52	125	32	[	[	-LRB-
cord-048322-5eqdrd52	125	33	74	74	CD
cord-048322-5eqdrd52	125	34	]	]	-RRB-
cord-048322-5eqdrd52	125	35	.	.	.
cord-048322-5eqdrd52	126	1	Most	Most	JJS
cord-048322-5eqdrd52	126	2	biological	biological	JJ
cord-048322-5eqdrd52	126	3	effects	effect	NNS
cord-048322-5eqdrd52	126	4	of	of	IN
cord-048322-5eqdrd52	126	5	the	the	DT
cord-048322-5eqdrd52	126	6	systemic	systemic	JJ
cord-048322-5eqdrd52	126	7	application	application	NN
cord-048322-5eqdrd52	126	8	of	of	IN
cord-048322-5eqdrd52	126	9	PEIcomplexed	PEIcomplexed	NNP
cord-048322-5eqdrd52	126	10	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	126	11	,	,	,
cord-048322-5eqdrd52	126	12	however	however	RB
cord-048322-5eqdrd52	126	13	,	,	,
cord-048322-5eqdrd52	126	14	have	have	VBP
cord-048322-5eqdrd52	126	15	been	be	VBN
cord-048322-5eqdrd52	126	16	determined	determine	VBN
cord-048322-5eqdrd52	126	17	in	in	IN
cord-048322-5eqdrd52	126	18	different	different	JJ
cord-048322-5eqdrd52	126	19	mouse	mouse	NN
cord-048322-5eqdrd52	126	20	tumor	tumor	NN
cord-048322-5eqdrd52	126	21	models	model	NNS
cord-048322-5eqdrd52	126	22	and	and	CC
cord-048322-5eqdrd52	126	23	by	by	IN
cord-048322-5eqdrd52	126	24	targeting	target	VBG
cord-048322-5eqdrd52	126	25	different	different	JJ
cord-048322-5eqdrd52	126	26	proteins	protein	NNS
cord-048322-5eqdrd52	126	27	which	which	WDT
cord-048322-5eqdrd52	126	28	have	have	VBP
cord-048322-5eqdrd52	126	29	been	be	VBN
cord-048322-5eqdrd52	126	30	shown	show	VBN
cord-048322-5eqdrd52	126	31	previously	previously	RB
cord-048322-5eqdrd52	126	32	to	to	TO
cord-048322-5eqdrd52	126	33	be	be	VB
cord-048322-5eqdrd52	126	34	tumor	tumor	NN
cord-048322-5eqdrd52	126	35	-	-	HYPH
cord-048322-5eqdrd52	126	36	relevant	relevant	JJ
cord-048322-5eqdrd52	126	37	.	.	.
cord-048322-5eqdrd52	127	1	This	this	DT
cord-048322-5eqdrd52	127	2	includes	include	VBZ
cord-048322-5eqdrd52	127	3	the	the	DT
cord-048322-5eqdrd52	127	4	epidermal	epidermal	JJ
cord-048322-5eqdrd52	127	5	growth	growth	NN
cord-048322-5eqdrd52	127	6	factor	factor	NN
cord-048322-5eqdrd52	127	7	receptor	receptor	NN
cord-048322-5eqdrd52	127	8	HER-2	HER-2	NNP
cord-048322-5eqdrd52	127	9	(	(	-LRB-
cord-048322-5eqdrd52	127	10	c	c	NN
cord-048322-5eqdrd52	127	11	-	-	:
cord-048322-5eqdrd52	127	12	erbB-2	erbB-2	NNP
cord-048322-5eqdrd52	127	13	/	/	SYM
cord-048322-5eqdrd52	127	14	neu	neu	NNP
cord-048322-5eqdrd52	127	15	)	)	-RRB-
cord-048322-5eqdrd52	127	16	,	,	,
cord-048322-5eqdrd52	127	17	the	the	DT
cord-048322-5eqdrd52	127	18	growth	growth	NN
cord-048322-5eqdrd52	127	19	factor	factor	NN
cord-048322-5eqdrd52	127	20	pleiotrophin	pleiotrophin	NNP
cord-048322-5eqdrd52	127	21	(	(	-LRB-
cord-048322-5eqdrd52	127	22	PTN	PTN	NNP
cord-048322-5eqdrd52	127	23	)	)	-RRB-
cord-048322-5eqdrd52	127	24	,	,	,
cord-048322-5eqdrd52	127	25	and	and	CC
cord-048322-5eqdrd52	127	26	vascular	vascular	JJ
cord-048322-5eqdrd52	127	27	endothelial	endothelial	JJ
cord-048322-5eqdrd52	127	28	growth	growth	NN
cord-048322-5eqdrd52	127	29	factor	factor	NN
cord-048322-5eqdrd52	127	30	(	(	-LRB-
cord-048322-5eqdrd52	127	31	VEGF	VEGF	NNP
cord-048322-5eqdrd52	127	32	)	)	-RRB-
cord-048322-5eqdrd52	127	33	and	and	CC
cord-048322-5eqdrd52	127	34	its	-PRON-	PRP$
cord-048322-5eqdrd52	127	35	receptor	receptor	NN
cord-048322-5eqdrd52	127	36	(	(	-LRB-
cord-048322-5eqdrd52	127	37	VEGF	VEGF	NNP
cord-048322-5eqdrd52	127	38	R2	R2	NNP
cord-048322-5eqdrd52	127	39	)	)	-RRB-
cord-048322-5eqdrd52	127	40	,	,	,
cord-048322-5eqdrd52	127	41	and	and	CC
cord-048322-5eqdrd52	127	42	the	the	DT
cord-048322-5eqdrd52	127	43	fibroblast	fibroblast	NN
cord-048322-5eqdrd52	127	44	growth	growth	NN
cord-048322-5eqdrd52	127	45	factor	factor	NN
cord-048322-5eqdrd52	127	46	-	-	HYPH
cord-048322-5eqdrd52	127	47	binding	bind	VBG
cord-048322-5eqdrd52	127	48	protein	protein	NN
cord-048322-5eqdrd52	127	49	FGF	FGF	NNP
cord-048322-5eqdrd52	127	50	-	-	HYPH
cord-048322-5eqdrd52	127	51	BP	BP	NNP
cord-048322-5eqdrd52	127	52	.	.	.
cord-048322-5eqdrd52	128	1	The	the	DT
cord-048322-5eqdrd52	128	2	in	in	IN
cord-048322-5eqdrd52	128	3	vivo	vivo	NNP
cord-048322-5eqdrd52	128	4	administration	administration	NN
cord-048322-5eqdrd52	128	5	of	of	IN
cord-048322-5eqdrd52	128	6	PEI	PEI	NNP
cord-048322-5eqdrd52	128	7	complexed	complexed	JJ
cord-048322-5eqdrd52	128	8	,	,	,
cord-048322-5eqdrd52	128	9	but	but	CC
cord-048322-5eqdrd52	128	10	not	not	RB
cord-048322-5eqdrd52	128	11	of	of	IN
cord-048322-5eqdrd52	128	12	naked	naked	JJ
cord-048322-5eqdrd52	128	13	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	128	14	,	,	,
cord-048322-5eqdrd52	128	15	through	through	IN
cord-048322-5eqdrd52	128	16	IP	ip	NN
cord-048322-5eqdrd52	128	17	or	or	CC
cord-048322-5eqdrd52	128	18	subcutaneous	subcutaneous	JJ
cord-048322-5eqdrd52	128	19	injection	injection	NN
cord-048322-5eqdrd52	128	20	resulted	result	VBD
cord-048322-5eqdrd52	128	21	in	in	IN
cord-048322-5eqdrd52	128	22	the	the	DT
cord-048322-5eqdrd52	128	23	detection	detection	NN
cord-048322-5eqdrd52	128	24	of	of	IN
cord-048322-5eqdrd52	128	25	intact	intact	JJ
cord-048322-5eqdrd52	128	26	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	128	27	even	even	RB
cord-048322-5eqdrd52	128	28	hours	hour	NNS
cord-048322-5eqdrd52	128	29	after	after	IN
cord-048322-5eqdrd52	128	30	injection	injection	NN
cord-048322-5eqdrd52	128	31	(	(	-LRB-
cord-048322-5eqdrd52	128	32	Figure	figure	NN
cord-048322-5eqdrd52	128	33	3(b	3(b	CD
cord-048322-5eqdrd52	128	34	)	)	-RRB-
cord-048322-5eqdrd52	128	35	)	)	-RRB-
cord-048322-5eqdrd52	128	36	.	.	.
cord-048322-5eqdrd52	129	1	Radiolabeled	Radiolabeled	NNP
cord-048322-5eqdrd52	129	2	siRNA	siRNA	NNP
cord-048322-5eqdrd52	129	3	molecules	molecule	NNS
cord-048322-5eqdrd52	129	4	were	be	VBD
cord-048322-5eqdrd52	129	5	found	find	VBN
cord-048322-5eqdrd52	129	6	in	in	IN
cord-048322-5eqdrd52	129	7	several	several	JJ
cord-048322-5eqdrd52	129	8	organs	organ	NNS
cord-048322-5eqdrd52	129	9	including	include	VBG
cord-048322-5eqdrd52	129	10	subcutaneous	subcutaneous	JJ
cord-048322-5eqdrd52	129	11	tumors	tumor	NNS
cord-048322-5eqdrd52	129	12	,	,	,
cord-048322-5eqdrd52	129	13	muscle	muscle	NN
cord-048322-5eqdrd52	129	14	liver	liver	NN
cord-048322-5eqdrd52	129	15	,	,	,
cord-048322-5eqdrd52	129	16	kidney	kidney	NN
cord-048322-5eqdrd52	129	17	and	and	CC
cord-048322-5eqdrd52	129	18	,	,	,
cord-048322-5eqdrd52	129	19	to	to	IN
cord-048322-5eqdrd52	129	20	a	a	DT
cord-048322-5eqdrd52	129	21	smaller	small	JJR
cord-048322-5eqdrd52	129	22	extent	extent	NN
cord-048322-5eqdrd52	129	23	,	,	,
cord-048322-5eqdrd52	129	24	lung	lung	NN
cord-048322-5eqdrd52	129	25	and	and	CC
cord-048322-5eqdrd52	129	26	brain	brain	NN
cord-048322-5eqdrd52	129	27	.	.	.
cord-048322-5eqdrd52	130	1	It	-PRON-	PRP
cord-048322-5eqdrd52	130	2	is	be	VBZ
cord-048322-5eqdrd52	130	3	important	important	JJ
cord-048322-5eqdrd52	130	4	to	to	TO
cord-048322-5eqdrd52	130	5	note	note	VB
cord-048322-5eqdrd52	130	6	that	that	IN
cord-048322-5eqdrd52	130	7	the	the	DT
cord-048322-5eqdrd52	130	8	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	130	9	were	be	VBD
cord-048322-5eqdrd52	130	10	actually	actually	RB
cord-048322-5eqdrd52	130	11	internalized	internalize	VBN
cord-048322-5eqdrd52	130	12	by	by	IN
cord-048322-5eqdrd52	130	13	the	the	DT
cord-048322-5eqdrd52	130	14	tissues	tissue	NNS
cord-048322-5eqdrd52	130	15	as	as	IN
cord-048322-5eqdrd52	130	16	indicated	indicate	VBN
cord-048322-5eqdrd52	130	17	by	by	IN
cord-048322-5eqdrd52	130	18	the	the	DT
cord-048322-5eqdrd52	130	19	fact	fact	NN
cord-048322-5eqdrd52	130	20	that	that	IN
cord-048322-5eqdrd52	130	21	blood	blood	NN
cord-048322-5eqdrd52	130	22	was	be	VBD
cord-048322-5eqdrd52	130	23	negative	negative	JJ
cord-048322-5eqdrd52	130	24	for	for	IN
cord-048322-5eqdrd52	130	25	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	130	26	(	(	-LRB-
cord-048322-5eqdrd52	130	27	Figure	figure	NN
cord-048322-5eqdrd52	130	28	3(b	3(b	CD
cord-048322-5eqdrd52	130	29	)	)	-RRB-
cord-048322-5eqdrd52	130	30	)	)	-RRB-
cord-048322-5eqdrd52	130	31	.	.	.
cord-048322-5eqdrd52	131	1	Overexpression	overexpression	NN
cord-048322-5eqdrd52	131	2	of	of	IN
cord-048322-5eqdrd52	131	3	the	the	DT
cord-048322-5eqdrd52	131	4	HER-2	HER-2	NNP
cord-048322-5eqdrd52	131	5	receptor	receptor	NN
cord-048322-5eqdrd52	131	6	has	have	VBZ
cord-048322-5eqdrd52	131	7	been	be	VBN
cord-048322-5eqdrd52	131	8	observed	observe	VBN
cord-048322-5eqdrd52	131	9	in	in	IN
cord-048322-5eqdrd52	131	10	a	a	DT
cord-048322-5eqdrd52	131	11	wide	wide	JJ
cord-048322-5eqdrd52	131	12	variety	variety	NN
cord-048322-5eqdrd52	131	13	of	of	IN
cord-048322-5eqdrd52	131	14	human	human	JJ
cord-048322-5eqdrd52	131	15	cancers	cancer	NNS
cord-048322-5eqdrd52	131	16	and	and	CC
cord-048322-5eqdrd52	131	17	cancer	cancer	NN
cord-048322-5eqdrd52	131	18	cell	cell	NN
cord-048322-5eqdrd52	131	19	lines	line	NNS
cord-048322-5eqdrd52	131	20	.	.	.
cord-048322-5eqdrd52	132	1	Since	since	IN
cord-048322-5eqdrd52	132	2	HER-2	HER-2	NNP
cord-048322-5eqdrd52	132	3	displays	display	VBZ
cord-048322-5eqdrd52	132	4	strong	strong	JJ
cord-048322-5eqdrd52	132	5	cell	cell	NN
cord-048322-5eqdrd52	132	6	growth	growth	NN
cord-048322-5eqdrd52	132	7	-	-	HYPH
cord-048322-5eqdrd52	132	8	stimulating	stimulate	VBG
cord-048322-5eqdrd52	132	9	and	and	CC
cord-048322-5eqdrd52	132	10	antiapoptotic	antiapoptotic	JJ
cord-048322-5eqdrd52	132	11	effects	effect	NNS
cord-048322-5eqdrd52	132	12	especially	especially	RB
cord-048322-5eqdrd52	132	13	through	through	IN
cord-048322-5eqdrd52	132	14	heterodimer	heterodimer	NN
cord-048322-5eqdrd52	132	15	formation	formation	NN
cord-048322-5eqdrd52	132	16	with	with	IN
cord-048322-5eqdrd52	132	17	other	other	JJ
cord-048322-5eqdrd52	132	18	members	member	NNS
cord-048322-5eqdrd52	132	19	of	of	IN
cord-048322-5eqdrd52	132	20	the	the	DT
cord-048322-5eqdrd52	132	21	EGFR	EGFR	NNP
cord-048322-5eqdrd52	132	22	family	family	NN
cord-048322-5eqdrd52	132	23	,	,	,
cord-048322-5eqdrd52	132	24	its	-PRON-	PRP$
cord-048322-5eqdrd52	132	25	overexpression	overexpression	NN
cord-048322-5eqdrd52	132	26	has	have	VBZ
cord-048322-5eqdrd52	132	27	been	be	VBN
cord-048322-5eqdrd52	132	28	established	establish	VBN
cord-048322-5eqdrd52	132	29	as	as	IN
cord-048322-5eqdrd52	132	30	a	a	DT
cord-048322-5eqdrd52	132	31	negative	negative	JJ
cord-048322-5eqdrd52	132	32	prognostic	prognostic	JJ
cord-048322-5eqdrd52	132	33	factor	factor	NN
cord-048322-5eqdrd52	132	34	and	and	CC
cord-048322-5eqdrd52	132	35	linked	link	VBN
cord-048322-5eqdrd52	132	36	to	to	IN
cord-048322-5eqdrd52	132	37	a	a	DT
cord-048322-5eqdrd52	132	38	more	more	RBR
cord-048322-5eqdrd52	132	39	aggressive	aggressive	JJ
cord-048322-5eqdrd52	132	40	malignant	malignant	JJ
cord-048322-5eqdrd52	132	41	behaviour	behaviour	NN
cord-048322-5eqdrd52	132	42	of	of	IN
cord-048322-5eqdrd52	132	43	tumors	tumor	NNS
cord-048322-5eqdrd52	132	44	(	(	-LRB-
cord-048322-5eqdrd52	132	45	eg	eg	IN
cord-048322-5eqdrd52	132	46	,	,	,
cord-048322-5eqdrd52	132	47	[	[	-LRB-
cord-048322-5eqdrd52	132	48	75	75	CD
cord-048322-5eqdrd52	132	49	]	]	-RRB-
cord-048322-5eqdrd52	132	50	)	)	-RRB-
cord-048322-5eqdrd52	132	51	.	.	.
cord-048322-5eqdrd52	133	1	Consequently	consequently	RB
cord-048322-5eqdrd52	133	2	,	,	,
cord-048322-5eqdrd52	133	3	HER-2	HER-2	NNP
cord-048322-5eqdrd52	133	4	qualifies	qualify	VBZ
cord-048322-5eqdrd52	133	5	as	as	IN
cord-048322-5eqdrd52	133	6	an	an	DT
cord-048322-5eqdrd52	133	7	attractive	attractive	JJ
cord-048322-5eqdrd52	133	8	target	target	NN
cord-048322-5eqdrd52	133	9	molecule	molecule	NN
cord-048322-5eqdrd52	133	10	for	for	IN
cord-048322-5eqdrd52	133	11	antitumoral	antitumoral	JJ
cord-048322-5eqdrd52	133	12	treatment	treatment	NN
cord-048322-5eqdrd52	133	13	strategies	strategy	NNS
cord-048322-5eqdrd52	133	14	including	include	VBG
cord-048322-5eqdrd52	133	15	anti	anti	JJ
cord-048322-5eqdrd52	133	16	-	-	JJ
cord-048322-5eqdrd52	133	17	HER-2	her-2	JJ
cord-048322-5eqdrd52	133	18	antibodies	antibody	NNS
cord-048322-5eqdrd52	133	19	,	,	,
cord-048322-5eqdrd52	133	20	low	low	JJ
cord-048322-5eqdrd52	133	21	molecular	molecular	JJ
cord-048322-5eqdrd52	133	22	weight	weight	NN
cord-048322-5eqdrd52	133	23	inhibitors	inhibitor	NNS
cord-048322-5eqdrd52	133	24	,	,	,
cord-048322-5eqdrd52	133	25	or	or	CC
cord-048322-5eqdrd52	133	26	HER-2-specific	HER-2-specific	NNP
cord-048322-5eqdrd52	133	27	gene	gene	NN
cord-048322-5eqdrd52	133	28	-	-	HYPH
cord-048322-5eqdrd52	133	29	targeting	target	VBG
cord-048322-5eqdrd52	133	30	approaches	approach	NNS
cord-048322-5eqdrd52	133	31	.	.	.
cord-048322-5eqdrd52	134	1	In	in	IN
cord-048322-5eqdrd52	134	2	fact	fact	NN
cord-048322-5eqdrd52	134	3	,	,	,
cord-048322-5eqdrd52	134	4	the	the	DT
cord-048322-5eqdrd52	134	5	relevance	relevance	NN
cord-048322-5eqdrd52	134	6	of	of	IN
cord-048322-5eqdrd52	134	7	HER-2	HER-2	NNP
cord-048322-5eqdrd52	135	1	(	(	-LRB-
cord-048322-5eqdrd52	135	2	over-)expression	over-)expression	NNP
cord-048322-5eqdrd52	135	3	in	in	IN
cord-048322-5eqdrd52	135	4	tumor	tumor	NN
cord-048322-5eqdrd52	135	5	growth	growth	NN
cord-048322-5eqdrd52	135	6	has	have	VBZ
cord-048322-5eqdrd52	135	7	been	be	VBN
cord-048322-5eqdrd52	135	8	established	establish	VBN
cord-048322-5eqdrd52	135	9	in	in	IN
cord-048322-5eqdrd52	135	10	several	several	JJ
cord-048322-5eqdrd52	135	11	in	in	IN
cord-048322-5eqdrd52	135	12	vitro	vitro	FW
cord-048322-5eqdrd52	135	13	HER-2	HER-2	NNP
cord-048322-5eqdrd52	135	14	targeting	target	VBG
cord-048322-5eqdrd52	135	15	studies	study	NNS
cord-048322-5eqdrd52	135	16	including	include	VBG
cord-048322-5eqdrd52	135	17	the	the	DT
cord-048322-5eqdrd52	135	18	use	use	NN
cord-048322-5eqdrd52	135	19	of	of	IN
cord-048322-5eqdrd52	135	20	ribozymes	ribozyme	NNS
cord-048322-5eqdrd52	135	21	[	[	-LRB-
cord-048322-5eqdrd52	135	22	76	76	CD
cord-048322-5eqdrd52	135	23	,	,	,
cord-048322-5eqdrd52	135	24	78	78	CD
cord-048322-5eqdrd52	135	25	,	,	,
cord-048322-5eqdrd52	135	26	79	79	CD
cord-048322-5eqdrd52	135	27	]	]	-RRB-
cord-048322-5eqdrd52	135	28	or	or	CC
cord-048322-5eqdrd52	136	1	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	136	2	[	[	-LRB-
cord-048322-5eqdrd52	136	3	80	80	CD
cord-048322-5eqdrd52	136	4	,	,	,
cord-048322-5eqdrd52	136	5	81	81	CD
cord-048322-5eqdrd52	136	6	]	]	-RRB-
cord-048322-5eqdrd52	136	7	.	.	.
cord-048322-5eqdrd52	137	1	proposed	propose	VBN
cord-048322-5eqdrd52	137	2	mechanism	mechanism	NN
cord-048322-5eqdrd52	137	3	of	of	IN
cord-048322-5eqdrd52	137	4	PEI	PEI	NNP
cord-048322-5eqdrd52	137	5	-	-	HYPH
cord-048322-5eqdrd52	137	6	mediated	mediate	VBN
cord-048322-5eqdrd52	137	7	siRNA	siRNA	NNP
cord-048322-5eqdrd52	137	8	transfer	transfer	NN
cord-048322-5eqdrd52	137	9	.	.	.
cord-048322-5eqdrd52	138	1	Due	due	IN
cord-048322-5eqdrd52	138	2	to	to	IN
cord-048322-5eqdrd52	138	3	electrostatic	electrostatic	JJ
cord-048322-5eqdrd52	138	4	interactions	interaction	NNS
cord-048322-5eqdrd52	138	5	,	,	,
cord-048322-5eqdrd52	138	6	PEI	PEI	NNP
cord-048322-5eqdrd52	138	7	is	be	VBZ
cord-048322-5eqdrd52	138	8	able	able	JJ
cord-048322-5eqdrd52	138	9	to	to	TO
cord-048322-5eqdrd52	138	10	complex	complex	VB
cord-048322-5eqdrd52	138	11	negatively	negatively	RB
cord-048322-5eqdrd52	138	12	charged	charge	VBN
cord-048322-5eqdrd52	138	13	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	138	14	leading	lead	VBG
cord-048322-5eqdrd52	138	15	to	to	IN
cord-048322-5eqdrd52	138	16	a	a	DT
cord-048322-5eqdrd52	138	17	compaction	compaction	NN
cord-048322-5eqdrd52	138	18	and	and	CC
cord-048322-5eqdrd52	138	19	the	the	DT
cord-048322-5eqdrd52	138	20	formation	formation	NN
cord-048322-5eqdrd52	138	21	of	of	IN
cord-048322-5eqdrd52	138	22	small	small	JJ
cord-048322-5eqdrd52	138	23	colloidal	colloidal	NN
cord-048322-5eqdrd52	138	24	particles	particle	NNS
cord-048322-5eqdrd52	138	25	which	which	WDT
cord-048322-5eqdrd52	138	26	are	be	VBP
cord-048322-5eqdrd52	138	27	endocytosed	endocytose	VBN
cord-048322-5eqdrd52	138	28	.	.	.
cord-048322-5eqdrd52	139	1	The	the	DT
cord-048322-5eqdrd52	139	2	"	"	``
cord-048322-5eqdrd52	139	3	proton	proton	NN
cord-048322-5eqdrd52	139	4	sponge	sponge	NN
cord-048322-5eqdrd52	139	5	effect	effect	NN
cord-048322-5eqdrd52	139	6	"	"	''
cord-048322-5eqdrd52	139	7	exhibited	exhibit	VBN
cord-048322-5eqdrd52	139	8	by	by	IN
cord-048322-5eqdrd52	139	9	PEI	PEI	NNP
cord-048322-5eqdrd52	139	10	complexes	complex	NNS
cord-048322-5eqdrd52	139	11	leads	lead	VBZ
cord-048322-5eqdrd52	139	12	to	to	IN
cord-048322-5eqdrd52	139	13	osmotic	osmotic	JJ
cord-048322-5eqdrd52	139	14	swelling	swelling	NN
cord-048322-5eqdrd52	139	15	and	and	CC
cord-048322-5eqdrd52	139	16	ultimately	ultimately	RB
cord-048322-5eqdrd52	139	17	to	to	IN
cord-048322-5eqdrd52	139	18	the	the	DT
cord-048322-5eqdrd52	139	19	disruption	disruption	NN
cord-048322-5eqdrd52	139	20	of	of	IN
cord-048322-5eqdrd52	139	21	the	the	DT
cord-048322-5eqdrd52	139	22	endosomes	endosome	NNS
cord-048322-5eqdrd52	139	23	.	.	.
cord-048322-5eqdrd52	140	1	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	140	2	are	be	VBP
cord-048322-5eqdrd52	140	3	protected	protect	VBN
cord-048322-5eqdrd52	140	4	from	from	IN
cord-048322-5eqdrd52	140	5	degradation	degradation	NN
cord-048322-5eqdrd52	140	6	due	due	IN
cord-048322-5eqdrd52	140	7	to	to	IN
cord-048322-5eqdrd52	140	8	their	-PRON-	PRP$
cord-048322-5eqdrd52	140	9	tight	tight	JJ
cord-048322-5eqdrd52	140	10	condensation	condensation	NN
cord-048322-5eqdrd52	140	11	in	in	IN
cord-048322-5eqdrd52	140	12	the	the	DT
cord-048322-5eqdrd52	140	13	complex	complex	NN
cord-048322-5eqdrd52	140	14	and	and	CC
cord-048322-5eqdrd52	140	15	the	the	DT
cord-048322-5eqdrd52	140	16	buffering	buffering	NN
cord-048322-5eqdrd52	140	17	capacity	capacity	NN
cord-048322-5eqdrd52	140	18	of	of	IN
cord-048322-5eqdrd52	140	19	PEI	PEI	NNP
cord-048322-5eqdrd52	140	20	.	.	.
cord-048322-5eqdrd52	141	1	Upon	upon	IN
cord-048322-5eqdrd52	141	2	their	-PRON-	PRP$
cord-048322-5eqdrd52	141	3	release	release	NN
cord-048322-5eqdrd52	141	4	from	from	IN
cord-048322-5eqdrd52	141	5	the	the	DT
cord-048322-5eqdrd52	141	6	PEI	PEI	NNP
cord-048322-5eqdrd52	141	7	-	-	HYPH
cord-048322-5eqdrd52	141	8	based	base	VBN
cord-048322-5eqdrd52	141	9	complex	complex	NN
cord-048322-5eqdrd52	141	10	,	,	,
cord-048322-5eqdrd52	141	11	intact	intact	JJ
cord-048322-5eqdrd52	141	12	siRNAs	sirna	NNS
cord-048322-5eqdrd52	141	13	are	be	VBP
cord-048322-5eqdrd52	141	14	incorporated	incorporate	VBN
cord-048322-5eqdrd52	141	15	into	into	IN
cord-048322-5eqdrd52	141	16	the	the	DT
cord-048322-5eqdrd52	141	17	RISC	RISC	NNP
cord-048322-5eqdrd52	141	18	complex	complex	NN
cord-048322-5eqdrd52	141	19	and	and	CC
cord-048322-5eqdrd52	141	20	induce	induce	VB
cord-048322-5eqdrd52	141	21	RNAi	RNAi	NNP
cord-048322-5eqdrd52	141	22	(	(	-LRB-
cord-048322-5eqdrd52	141	23	see	see	VB
cord-048322-5eqdrd52	141	24	Figure	Figure	NNP
cord-048322-5eqdrd52	141	25	1	1	CD
cord-048322-5eqdrd52	141	26	)	)	-RRB-
cord-048322-5eqdrd52	141	27	.	.	.
cord-048322-5eqdrd52	142	1	It	-PRON-	PRP
cord-048322-5eqdrd52	142	2	was	be	VBD
cord-048322-5eqdrd52	142	3	demonstrated	demonstrate	VBN
cord-048322-5eqdrd52	142	4	that	that	IN
cord-048322-5eqdrd52	142	5	HER-2	HER-2	NNP
cord-048322-5eqdrd52	142	6	reduction	reduction	NN
cord-048322-5eqdrd52	142	7	in	in	IN
cord-048322-5eqdrd52	142	8	vitro	vitro	FW
cord-048322-5eqdrd52	142	9	leads	lead	VBZ
cord-048322-5eqdrd52	142	10	,	,	,
cord-048322-5eqdrd52	142	11	among	among	IN
cord-048322-5eqdrd52	142	12	others	other	NNS
cord-048322-5eqdrd52	142	13	,	,	,
cord-048322-5eqdrd52	142	14	to	to	IN
cord-048322-5eqdrd52	142	15	the	the	DT
cord-048322-5eqdrd52	142	16	inhibition	inhibition	NN
cord-048322-5eqdrd52	142	17	of	of	IN
cord-048322-5eqdrd52	142	18	cell	cell	NN
cord-048322-5eqdrd52	142	19	proliferation	proliferation	NN
cord-048322-5eqdrd52	142	20	and	and	CC
cord-048322-5eqdrd52	142	21	increased	increase	VBN
cord-048322-5eqdrd52	142	22	apoptosis	apoptosis	NN
cord-048322-5eqdrd52	142	23	.	.	.
cord-048322-5eqdrd52	143	1	The	the	DT
cord-048322-5eqdrd52	143	2	systemic	systemic	JJ
cord-048322-5eqdrd52	143	3	treatment	treatment	NN
cord-048322-5eqdrd52	143	4	of	of	IN
cord-048322-5eqdrd52	143	5	athymic	athymic	JJ
cord-048322-5eqdrd52	143	6	nude	nude	JJ
cord-048322-5eqdrd52	143	7	mice	mouse	NNS
cord-048322-5eqdrd52	143	8	bearing	bear	VBG
cord-048322-5eqdrd52	143	9	subcutaneous	subcutaneous	JJ
cord-048322-5eqdrd52	143	10	SKOV-3	SKOV-3	NNP
cord-048322-5eqdrd52	143	11	ovarian	ovarian	JJ
cord-048322-5eqdrd52	143	12	carcinoma	carcinoma	NN
cord-048322-5eqdrd52	143	13	tumor	tumor	NN
cord-048322-5eqdrd52	143	14	xenografts	xenograft	NNS
cord-048322-5eqdrd52	143	15	through	through	IN
cord-048322-5eqdrd52	143	16	IP	ip	NN
cord-048322-5eqdrd52	143	17	injection	injection	NN
cord-048322-5eqdrd52	143	18	of	of	IN
cord-048322-5eqdrd52	143	19	PEI	PEI	NNP
cord-048322-5eqdrd52	143	20	-	-	HYPH
cord-048322-5eqdrd52	143	21	complexed	complexe	VBN
cord-048322-5eqdrd52	143	22	HER-2-specific	HER-2-specific	NNP
cord-048322-5eqdrd52	143	23	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	143	24	led	lead	VBD
cord-048322-5eqdrd52	143	25	to	to	IN
cord-048322-5eqdrd52	143	26	marked	mark	VBN
cord-048322-5eqdrd52	143	27	antitumoral	antitumoral	JJ
cord-048322-5eqdrd52	143	28	effects	effect	NNS
cord-048322-5eqdrd52	143	29	as	as	IN
cord-048322-5eqdrd52	143	30	seen	see	VBN
cord-048322-5eqdrd52	143	31	by	by	IN
cord-048322-5eqdrd52	143	32	a	a	DT
cord-048322-5eqdrd52	143	33	significant	significant	JJ
cord-048322-5eqdrd52	143	34	reduction	reduction	NN
cord-048322-5eqdrd52	143	35	tumor	tumor	NN
cord-048322-5eqdrd52	143	36	growth	growth	NN
cord-048322-5eqdrd52	143	37	(	(	-LRB-
cord-048322-5eqdrd52	143	38	Figure	figure	NN
cord-048322-5eqdrd52	143	39	4	4	CD
cord-048322-5eqdrd52	143	40	)	)	-RRB-
cord-048322-5eqdrd52	143	41	[	[	-LRB-
cord-048322-5eqdrd52	143	42	70	70	CD
cord-048322-5eqdrd52	143	43	]	]	-RRB-
cord-048322-5eqdrd52	143	44	.	.	.
cord-048322-5eqdrd52	144	1	PEIcomplexed	PEIcomplexed	NNP
cord-048322-5eqdrd52	144	2	nonspecific	nonspecific	JJ
cord-048322-5eqdrd52	144	3	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	144	4	or	or	CC
cord-048322-5eqdrd52	144	5	HER-2-specific	her-2-specific	NN
cord-048322-5eqdrd52	144	6	,	,	,
cord-048322-5eqdrd52	144	7	naked	naked	JJ
cord-048322-5eqdrd52	144	8	siR	siR	NNP
cord-048322-5eqdrd52	144	9	-	-	HYPH
cord-048322-5eqdrd52	144	10	NAs	NAs	NNPS
cord-048322-5eqdrd52	144	11	had	have	VBD
cord-048322-5eqdrd52	144	12	no	no	DT
cord-048322-5eqdrd52	144	13	effects	effect	NNS
cord-048322-5eqdrd52	144	14	.	.	.
cord-048322-5eqdrd52	145	1	This	this	DT
cord-048322-5eqdrd52	145	2	was	be	VBD
cord-048322-5eqdrd52	145	3	paralleled	parallel	VBN
cord-048322-5eqdrd52	145	4	by	by	IN
cord-048322-5eqdrd52	145	5	the	the	DT
cord-048322-5eqdrd52	145	6	detection	detection	NN
cord-048322-5eqdrd52	145	7	of	of	IN
cord-048322-5eqdrd52	145	8	intact	intact	JJ
cord-048322-5eqdrd52	145	9	HER-2-specific	HER-2-specific	NNP
cord-048322-5eqdrd52	145	10	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	145	11	in	in	IN
cord-048322-5eqdrd52	145	12	the	the	DT
cord-048322-5eqdrd52	145	13	tumors	tumor	NNS
cord-048322-5eqdrd52	145	14	of	of	IN
cord-048322-5eqdrd52	145	15	the	the	DT
cord-048322-5eqdrd52	145	16	specific	specific	JJ
cord-048322-5eqdrd52	145	17	treatment	treatment	NN
cord-048322-5eqdrd52	145	18	group	group	NN
cord-048322-5eqdrd52	146	1	already	already	RB
cord-048322-5eqdrd52	146	2	30	30	CD
cord-048322-5eqdrd52	146	3	min	min	NN
cord-048322-5eqdrd52	146	4	after	after	IN
cord-048322-5eqdrd52	146	5	administration	administration	NN
cord-048322-5eqdrd52	146	6	and	and	CC
cord-048322-5eqdrd52	146	7	for	for	IN
cord-048322-5eqdrd52	146	8	at	at	RB
cord-048322-5eqdrd52	146	9	least	least	JJS
cord-048322-5eqdrd52	146	10	4	4	CD
cord-048322-5eqdrd52	146	11	h	h	NN
cord-048322-5eqdrd52	146	12	,	,	,
cord-048322-5eqdrd52	146	13	and	and	CC
cord-048322-5eqdrd52	146	14	by	by	IN
cord-048322-5eqdrd52	146	15	the	the	DT
cord-048322-5eqdrd52	146	16	downregulation	downregulation	NN
cord-048322-5eqdrd52	146	17	of	of	IN
cord-048322-5eqdrd52	146	18	HER-2	HER-2	NNP
cord-048322-5eqdrd52	146	19	on	on	IN
cord-048322-5eqdrd52	146	20	mRNA	mrna	NN
cord-048322-5eqdrd52	146	21	and	and	CC
cord-048322-5eqdrd52	146	22	protein	protein	NN
cord-048322-5eqdrd52	146	23	levels	level	NNS
cord-048322-5eqdrd52	146	24	[	[	-LRB-
cord-048322-5eqdrd52	146	25	70	70	CD
cord-048322-5eqdrd52	146	26	]	]	-RRB-
cord-048322-5eqdrd52	146	27	.	.	.
cord-048322-5eqdrd52	147	1	Another	another	DT
cord-048322-5eqdrd52	147	2	receptor	receptor	NN
cord-048322-5eqdrd52	147	3	,	,	,
cord-048322-5eqdrd52	147	4	VEGF	VEGF	NNP
cord-048322-5eqdrd52	147	5	R2	R2	NNP
cord-048322-5eqdrd52	147	6	,	,	,
cord-048322-5eqdrd52	147	7	was	be	VBD
cord-048322-5eqdrd52	147	8	targeted	target	VBN
cord-048322-5eqdrd52	147	9	in	in	IN
cord-048322-5eqdrd52	147	10	a	a	DT
cord-048322-5eqdrd52	147	11	study	study	NN
cord-048322-5eqdrd52	147	12	employing	employ	VBG
cord-048322-5eqdrd52	147	13	self	self	NN
cord-048322-5eqdrd52	147	14	-	-	HYPH
cord-048322-5eqdrd52	147	15	assembling	assemble	VBG
cord-048322-5eqdrd52	147	16	nanoparticles	nanoparticle	NNS
cord-048322-5eqdrd52	147	17	based	base	VBN
cord-048322-5eqdrd52	147	18	on	on	IN
cord-048322-5eqdrd52	147	19	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	147	20	complexed	complexed	JJ
cord-048322-5eqdrd52	147	21	PEI	PEI	NNP
cord-048322-5eqdrd52	147	22	which	which	WDT
cord-048322-5eqdrd52	147	23	is	be	VBZ
cord-048322-5eqdrd52	147	24	PEGylated	pegylate	VBN
cord-048322-5eqdrd52	147	25	with	with	IN
cord-048322-5eqdrd52	147	26	an	an	DT
cord-048322-5eqdrd52	147	27	RGD	RGD	NNP
cord-048322-5eqdrd52	147	28	peptide	peptide	NN
cord-048322-5eqdrd52	147	29	ligand	ligand	NN
cord-048322-5eqdrd52	147	30	attached	attach	VBN
cord-048322-5eqdrd52	147	31	at	at	IN
cord-048322-5eqdrd52	147	32	the	the	DT
cord-048322-5eqdrd52	147	33	distal	distal	JJ
cord-048322-5eqdrd52	147	34	end	end	NN
cord-048322-5eqdrd52	147	35	of	of	IN
cord-048322-5eqdrd52	147	36	PEG	peg	NN
cord-048322-5eqdrd52	147	37	.	.	.
cord-048322-5eqdrd52	148	1	While	while	IN
cord-048322-5eqdrd52	148	2	the	the	DT
cord-048322-5eqdrd52	148	3	PEGylation	pegylation	NN
cord-048322-5eqdrd52	148	4	allows	allow	VBZ
cord-048322-5eqdrd52	148	5	steric	steric	JJ
cord-048322-5eqdrd52	148	6	stabilization	stabilization	NN
cord-048322-5eqdrd52	148	7	and	and	CC
cord-048322-5eqdrd52	148	8	reduces	reduce	VBZ
cord-048322-5eqdrd52	148	9	nonspecific	nonspecific	JJ
cord-048322-5eqdrd52	148	10	interactions	interaction	NNS
cord-048322-5eqdrd52	148	11	of	of	IN
cord-048322-5eqdrd52	148	12	the	the	DT
cord-048322-5eqdrd52	148	13	complexes	complex	NNS
cord-048322-5eqdrd52	148	14	,	,	,
cord-048322-5eqdrd52	148	15	the	the	DT
cord-048322-5eqdrd52	148	16	RGD	RGD	NNP
cord-048322-5eqdrd52	148	17	motif	motif	NN
cord-048322-5eqdrd52	148	18	provided	provide	VBD
cord-048322-5eqdrd52	148	19	tumor	tumor	NN
cord-048322-5eqdrd52	148	20	selectivity	selectivity	NN
cord-048322-5eqdrd52	148	21	due	due	IN
cord-048322-5eqdrd52	148	22	to	to	IN
cord-048322-5eqdrd52	148	23	their	-PRON-	PRP$
cord-048322-5eqdrd52	148	24	ability	ability	NN
cord-048322-5eqdrd52	148	25	to	to	TO
cord-048322-5eqdrd52	148	26	target	target	VB
cord-048322-5eqdrd52	148	27	integrins	integrin	NNS
cord-048322-5eqdrd52	148	28	expressed	express	VBN
cord-048322-5eqdrd52	148	29	on	on	IN
cord-048322-5eqdrd52	148	30	activated	activate	VBN
cord-048322-5eqdrd52	148	31	endothelial	endothelial	JJ
cord-048322-5eqdrd52	148	32	cells	cell	NNS
cord-048322-5eqdrd52	148	33	in	in	IN
cord-048322-5eqdrd52	148	34	the	the	DT
cord-048322-5eqdrd52	148	35	tumor	tumor	NN
cord-048322-5eqdrd52	148	36	vasculature	vasculature	NN
cord-048322-5eqdrd52	148	37	.	.	.
cord-048322-5eqdrd52	149	1	Upon	upon	IN
cord-048322-5eqdrd52	149	2	IV	IV	NNP
cord-048322-5eqdrd52	149	3	administration	administration	NN
cord-048322-5eqdrd52	149	4	into	into	IN
cord-048322-5eqdrd52	149	5	mice	mouse	NNS
cord-048322-5eqdrd52	149	6	bearing	bear	VBG
cord-048322-5eqdrd52	149	7	subcutaneous	subcutaneous	JJ
cord-048322-5eqdrd52	149	8	N2A	n2a	CD
cord-048322-5eqdrd52	149	9	neuroblastoma	neuroblastoma	NN
cord-048322-5eqdrd52	149	10	tumor	tumor	NN
cord-048322-5eqdrd52	149	11	xenografts	xenograft	NNS
cord-048322-5eqdrd52	149	12	,	,	,
cord-048322-5eqdrd52	149	13	a	a	DT
cord-048322-5eqdrd52	149	14	selective	selective	JJ
cord-048322-5eqdrd52	149	15	tumor	tumor	NN
cord-048322-5eqdrd52	149	16	uptake	uptake	NN
cord-048322-5eqdrd52	149	17	and	and	CC
cord-048322-5eqdrd52	149	18	a	a	DT
cord-048322-5eqdrd52	149	19	VEGF	VEGF	NNP
cord-048322-5eqdrd52	149	20	R2	R2	NNP
cord-048322-5eqdrd52	149	21	downregulation	downregulation	NN
cord-048322-5eqdrd52	149	22	were	be	VBD
cord-048322-5eqdrd52	149	23	observed	observe	VBN
cord-048322-5eqdrd52	149	24	,	,	,
cord-048322-5eqdrd52	149	25	resulting	result	VBG
cord-048322-5eqdrd52	149	26	in	in	IN
cord-048322-5eqdrd52	149	27	decreased	decreased	JJ
cord-048322-5eqdrd52	149	28	tumor	tumor	NN
cord-048322-5eqdrd52	149	29	growth	growth	NN
cord-048322-5eqdrd52	149	30	and	and	CC
cord-048322-5eqdrd52	149	31	tumor	tumor	NN
cord-048322-5eqdrd52	149	32	angiogenesis	angiogenesis	NN
cord-048322-5eqdrd52	149	33	[	[	-LRB-
cord-048322-5eqdrd52	149	34	73	73	CD
cord-048322-5eqdrd52	149	35	]	]	-RRB-
cord-048322-5eqdrd52	149	36	.	.	.
cord-048322-5eqdrd52	150	1	The	the	DT
cord-048322-5eqdrd52	150	2	receptor	receptor	NN
cord-048322-5eqdrd52	150	3	ligand	ligand	NN
cord-048322-5eqdrd52	150	4	,	,	,
cord-048322-5eqdrd52	150	5	VEGF	VEGF	NNP
cord-048322-5eqdrd52	150	6	,	,	,
cord-048322-5eqdrd52	150	7	is	be	VBZ
cord-048322-5eqdrd52	150	8	a	a	DT
cord-048322-5eqdrd52	150	9	mitogenic	mitogenic	JJ
cord-048322-5eqdrd52	150	10	and	and	CC
cord-048322-5eqdrd52	150	11	angiogenic	angiogenic	JJ
cord-048322-5eqdrd52	150	12	growth	growth	NN
cord-048322-5eqdrd52	150	13	factor	factor	NN
cord-048322-5eqdrd52	150	14	stimulating	stimulate	VBG
cord-048322-5eqdrd52	150	15	tumor	tumor	NN
cord-048322-5eqdrd52	150	16	growth	growth	NN
cord-048322-5eqdrd52	150	17	and	and	CC
cord-048322-5eqdrd52	150	18	angiogenesis	angiogenesis	NN
cord-048322-5eqdrd52	150	19	in	in	IN
cord-048322-5eqdrd52	150	20	several	several	JJ
cord-048322-5eqdrd52	150	21	tumors	tumor	NNS
cord-048322-5eqdrd52	150	22	including	include	VBG
cord-048322-5eqdrd52	150	23	prostate	prostate	NN
cord-048322-5eqdrd52	150	24	carcinoma	carcinoma	NN
cord-048322-5eqdrd52	150	25	.	.	.
cord-048322-5eqdrd52	151	1	Thus	thus	RB
cord-048322-5eqdrd52	151	2	,	,	,
cord-048322-5eqdrd52	151	3	it	-PRON-	PRP
cord-048322-5eqdrd52	151	4	may	may	MD
cord-048322-5eqdrd52	151	5	represent	represent	VB
cord-048322-5eqdrd52	151	6	attractive	attractive	JJ
cord-048322-5eqdrd52	151	7	target	target	NN
cord-048322-5eqdrd52	151	8	molecule	molecule	NN
cord-048322-5eqdrd52	151	9	for	for	IN
cord-048322-5eqdrd52	151	10	RNAi	RNAi	NNP
cord-048322-5eqdrd52	151	11	-	-	HYPH
cord-048322-5eqdrd52	151	12	based	base	VBN
cord-048322-5eqdrd52	151	13	genetargeting	genetargeting	NN
cord-048322-5eqdrd52	151	14	strategies	strategy	NNS
cord-048322-5eqdrd52	151	15	also	also	RB
cord-048322-5eqdrd52	151	16	bearing	bear	VBG
cord-048322-5eqdrd52	151	17	in	in	IN
cord-048322-5eqdrd52	151	18	mind	mind	NN
cord-048322-5eqdrd52	151	19	the	the	DT
cord-048322-5eqdrd52	151	20	double	double	JJ
cord-048322-5eqdrd52	151	21	antitumoral	antitumoral	JJ
cord-048322-5eqdrd52	151	22	effect	effect	NN
cord-048322-5eqdrd52	151	23	due	due	IN
cord-048322-5eqdrd52	151	24	to	to	IN
cord-048322-5eqdrd52	151	25	reduction	reduction	NN
cord-048322-5eqdrd52	151	26	of	of	IN
cord-048322-5eqdrd52	151	27	tumor	tumor	NN
cord-048322-5eqdrd52	151	28	cell	cell	NN
cord-048322-5eqdrd52	151	29	proliferation	proliferation	NN
cord-048322-5eqdrd52	151	30	as	as	RB
cord-048322-5eqdrd52	151	31	well	well	RB
cord-048322-5eqdrd52	151	32	as	as	IN
cord-048322-5eqdrd52	151	33	tumor	tumor	NN
cord-048322-5eqdrd52	151	34	angiogenesis	angiogenesis	NN
cord-048322-5eqdrd52	151	35	.	.	.
cord-048322-5eqdrd52	152	1	The	the	DT
cord-048322-5eqdrd52	152	2	subcutaneous	subcutaneous	JJ
cord-048322-5eqdrd52	152	3	or	or	CC
cord-048322-5eqdrd52	152	4	intraperitoneal	intraperitoneal	JJ
cord-048322-5eqdrd52	152	5	injection	injection	NN
cord-048322-5eqdrd52	152	6	of	of	IN
cord-048322-5eqdrd52	152	7	VEGF	VEGF	NNP
cord-048322-5eqdrd52	152	8	-	-	HYPH
cord-048322-5eqdrd52	152	9	specific	specific	JJ
cord-048322-5eqdrd52	152	10	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	152	11	complexed	complexed	JJ
cord-048322-5eqdrd52	152	12	with	with	IN
cord-048322-5eqdrd52	152	13	a	a	DT
cord-048322-5eqdrd52	152	14	novel	novel	JJ
cord-048322-5eqdrd52	152	15	PEI	PEI	NNP
cord-048322-5eqdrd52	152	16	obtained	obtain	VBD
cord-048322-5eqdrd52	152	17	through	through	IN
cord-048322-5eqdrd52	152	18	fractionation	fractionation	NN
cord-048322-5eqdrd52	152	19	of	of	IN
cord-048322-5eqdrd52	152	20	a	a	DT
cord-048322-5eqdrd52	152	21	commercially	commercially	RB
cord-048322-5eqdrd52	152	22	available	available	JJ
cord-048322-5eqdrd52	152	23	PEI	PEI	NNP
cord-048322-5eqdrd52	152	24	(	(	-LRB-
cord-048322-5eqdrd52	152	25	Werth	Werth	NNP
cord-048322-5eqdrd52	152	26	et	et	NNP
cord-048322-5eqdrd52	152	27	al	al	NNP
cord-048322-5eqdrd52	152	28	,	,	,
cord-048322-5eqdrd52	152	29	in	in	IN
cord-048322-5eqdrd52	152	30	press	press	NN
cord-048322-5eqdrd52	152	31	)	)	-RRB-
cord-048322-5eqdrd52	152	32	resulted	result	VBD
cord-048322-5eqdrd52	152	33	in	in	IN
cord-048322-5eqdrd52	152	34	the	the	DT
cord-048322-5eqdrd52	152	35	reduction	reduction	NN
cord-048322-5eqdrd52	152	36	of	of	IN
cord-048322-5eqdrd52	152	37	tumor	tumor	NN
cord-048322-5eqdrd52	152	38	growth	growth	NN
cord-048322-5eqdrd52	152	39	due	due	JJ
cord-048322-5eqdrd52	152	40	to	to	IN
cord-048322-5eqdrd52	152	41	decreased	decrease	VBN
cord-048322-5eqdrd52	152	42	VEGF	VEGF	NNP
cord-048322-5eqdrd52	152	43	expression	expression	NN
cord-048322-5eqdrd52	152	44	levels	level	NNS
cord-048322-5eqdrd52	152	45	(	(	-LRB-
cord-048322-5eqdrd52	152	46	Höbel	Höbel	NNP
cord-048322-5eqdrd52	152	47	and	and	CC
cord-048322-5eqdrd52	152	48	Aigner	Aigner	NNP
cord-048322-5eqdrd52	152	49	,	,	,
cord-048322-5eqdrd52	152	50	unpublished	unpublished	JJ
cord-048322-5eqdrd52	152	51	results	result	NNS
cord-048322-5eqdrd52	152	52	)	)	-RRB-
cord-048322-5eqdrd52	152	53	.	.	.
cord-048322-5eqdrd52	153	1	The	the	DT
cord-048322-5eqdrd52	153	2	same	same	JJ
cord-048322-5eqdrd52	153	3	was	be	VBD
cord-048322-5eqdrd52	153	4	true	true	JJ
cord-048322-5eqdrd52	153	5	for	for	IN
cord-048322-5eqdrd52	153	6	PEI	PEI	NNP
cord-048322-5eqdrd52	153	7	/	/	SYM
cord-048322-5eqdrd52	153	8	siRNA	siRNA	NNP
cord-048322-5eqdrd52	153	9	-	-	HYPH
cord-048322-5eqdrd52	153	10	mediated	mediate	VBN
cord-048322-5eqdrd52	153	11	targeting	targeting	NN
cord-048322-5eqdrd52	153	12	of	of	IN
cord-048322-5eqdrd52	153	13	FGF	FGF	NNP
cord-048322-5eqdrd52	153	14	-	-	HYPH
cord-048322-5eqdrd52	153	15	BP	BP	NNP
cord-048322-5eqdrd52	153	16	(	(	-LRB-
cord-048322-5eqdrd52	153	17	Dai	Dai	NNP
cord-048322-5eqdrd52	153	18	and	and	CC
cord-048322-5eqdrd52	153	19	Aigner	Aigner	NNP
cord-048322-5eqdrd52	153	20	,	,	,
cord-048322-5eqdrd52	153	21	unpublished	unpublished	JJ
cord-048322-5eqdrd52	153	22	results	result	NNS
cord-048322-5eqdrd52	153	23	)	)	-RRB-
cord-048322-5eqdrd52	153	24	,	,	,
cord-048322-5eqdrd52	153	25	which	which	WDT
cord-048322-5eqdrd52	153	26	has	have	VBZ
cord-048322-5eqdrd52	153	27	been	be	VBN
cord-048322-5eqdrd52	153	28	established	establish	VBN
cord-048322-5eqdrd52	153	29	Figure	figure	NN
cord-048322-5eqdrd52	153	30	3	3	CD
cord-048322-5eqdrd52	153	31	:	:	:
cord-048322-5eqdrd52	153	32	Protection	protection	NN
cord-048322-5eqdrd52	153	33	and	and	CC
cord-048322-5eqdrd52	153	34	in	in	IN
cord-048322-5eqdrd52	153	35	vivo	vivo	NN
cord-048322-5eqdrd52	153	36	delivery	delivery	NN
cord-048322-5eqdrd52	153	37	of	of	IN
cord-048322-5eqdrd52	153	38	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	153	39	upon	upon	IN
cord-048322-5eqdrd52	153	40	PEI	PEI	NNP
cord-048322-5eqdrd52	153	41	complexation	complexation	NN
cord-048322-5eqdrd52	153	42	.	.	.
cord-048322-5eqdrd52	154	1	In	in	IN
cord-048322-5eqdrd52	154	2	[	[	-LRB-
cord-048322-5eqdrd52	154	3	70	70	CD
cord-048322-5eqdrd52	154	4	]	]	-RRB-
cord-048322-5eqdrd52	154	5	(	(	-LRB-
cord-048322-5eqdrd52	154	6	a	a	LS
cord-048322-5eqdrd52	154	7	)	)	-RRB-
cord-048322-5eqdrd52	154	8	in	in	IN
cord-048322-5eqdrd52	154	9	vitro	vitro	FW
cord-048322-5eqdrd52	154	10	protection	protection	NN
cord-048322-5eqdrd52	154	11	of	of	IN
cord-048322-5eqdrd52	154	12	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	154	13	against	against	IN
cord-048322-5eqdrd52	154	14	nucleolytic	nucleolytic	JJ
cord-048322-5eqdrd52	154	15	degradation	degradation	NN
cord-048322-5eqdrd52	154	16	.	.	.
cord-048322-5eqdrd52	155	1	[	[	-LRB-
cord-048322-5eqdrd52	155	2	32	32	CD
cord-048322-5eqdrd52	155	3	P	p	NN
cord-048322-5eqdrd52	155	4	]	]	-RRB-
cord-048322-5eqdrd52	155	5	end	end	NN
cord-048322-5eqdrd52	155	6	-	-	HYPH
cord-048322-5eqdrd52	155	7	labeled	label	VBN
cord-048322-5eqdrd52	155	8	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	155	9	,	,	,
cord-048322-5eqdrd52	155	10	complexed	complexed	JJ
cord-048322-5eqdrd52	155	11	(	(	-LRB-
cord-048322-5eqdrd52	155	12	upper	upper	JJ
cord-048322-5eqdrd52	155	13	panel	panel	NN
cord-048322-5eqdrd52	155	14	)	)	-RRB-
cord-048322-5eqdrd52	155	15	or	or	CC
cord-048322-5eqdrd52	155	16	not	not	RB
cord-048322-5eqdrd52	155	17	complexed	complexed	JJ
cord-048322-5eqdrd52	155	18	(	(	-LRB-
cord-048322-5eqdrd52	155	19	lower	low	JJR
cord-048322-5eqdrd52	155	20	panel	panel	NN
cord-048322-5eqdrd52	155	21	)	)	-RRB-
cord-048322-5eqdrd52	155	22	with	with	IN
cord-048322-5eqdrd52	155	23	PEI	PEI	NNP
cord-048322-5eqdrd52	155	24	,	,	,
cord-048322-5eqdrd52	155	25	were	be	VBD
cord-048322-5eqdrd52	155	26	subjected	subject	VBN
cord-048322-5eqdrd52	155	27	to	to	IN
cord-048322-5eqdrd52	155	28	treatment	treatment	NN
cord-048322-5eqdrd52	155	29	with	with	IN
cord-048322-5eqdrd52	155	30	1	1	CD
cord-048322-5eqdrd52	155	31	%	%	NN
cord-048322-5eqdrd52	155	32	fetal	fetal	JJ
cord-048322-5eqdrd52	155	33	calf	calf	NN
cord-048322-5eqdrd52	155	34	serum	serum	NN
cord-048322-5eqdrd52	155	35	at	at	IN
cord-048322-5eqdrd52	155	36	37	37	CD
cord-048322-5eqdrd52	156	1	•	•	NNP
cord-048322-5eqdrd52	157	1	C.	C.	NNP
cord-048322-5eqdrd52	158	1	At	at	IN
cord-048322-5eqdrd52	158	2	the	the	DT
cord-048322-5eqdrd52	158	3	time	time	NN
cord-048322-5eqdrd52	158	4	points	point	NNS
cord-048322-5eqdrd52	158	5	indicated	indicate	VBN
cord-048322-5eqdrd52	158	6	,	,	,
cord-048322-5eqdrd52	158	7	the	the	DT
cord-048322-5eqdrd52	158	8	samples	sample	NNS
cord-048322-5eqdrd52	158	9	were	be	VBD
cord-048322-5eqdrd52	158	10	analysed	analyse	VBN
cord-048322-5eqdrd52	158	11	by	by	IN
cord-048322-5eqdrd52	158	12	agarose	agarose	JJ
cord-048322-5eqdrd52	158	13	gel	gel	NN
cord-048322-5eqdrd52	158	14	electrophoresis	electrophoresis	NN
cord-048322-5eqdrd52	158	15	,	,	,
cord-048322-5eqdrd52	158	16	blotting	blotting	NN
cord-048322-5eqdrd52	158	17	,	,	,
cord-048322-5eqdrd52	158	18	and	and	CC
cord-048322-5eqdrd52	158	19	autoradiography	autoradiography	NN
cord-048322-5eqdrd52	158	20	.	.	.
cord-048322-5eqdrd52	159	1	The	the	DT
cord-048322-5eqdrd52	159	2	bands	band	NNS
cord-048322-5eqdrd52	159	3	represent	represent	VBP
cord-048322-5eqdrd52	159	4	full	full	JJ
cord-048322-5eqdrd52	159	5	-	-	HYPH
cord-048322-5eqdrd52	159	6	length	length	NN
cord-048322-5eqdrd52	159	7	siRNA	sirna	NN
cord-048322-5eqdrd52	159	8	molecules	molecule	NNS
cord-048322-5eqdrd52	159	9	indicating	indicate	VBG
cord-048322-5eqdrd52	159	10	that	that	IN
cord-048322-5eqdrd52	159	11	PEI	PEI	NNP
cord-048322-5eqdrd52	159	12	complexation	complexation	NN
cord-048322-5eqdrd52	159	13	leads	lead	VBZ
cord-048322-5eqdrd52	159	14	to	to	IN
cord-048322-5eqdrd52	159	15	the	the	DT
cord-048322-5eqdrd52	159	16	efficient	efficient	JJ
cord-048322-5eqdrd52	159	17	protection	protection	NN
cord-048322-5eqdrd52	159	18	of	of	IN
cord-048322-5eqdrd52	159	19	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	159	20	while	while	IN
cord-048322-5eqdrd52	159	21	noncomplexed	noncomplexed	NNP
cord-048322-5eqdrd52	159	22	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	159	23	are	be	VBP
cord-048322-5eqdrd52	159	24	rapidly	rapidly	RB
cord-048322-5eqdrd52	159	25	degraded	degrade	VBN
cord-048322-5eqdrd52	159	26	.	.	.
cord-048322-5eqdrd52	160	1	(	(	-LRB-
cord-048322-5eqdrd52	160	2	b	b	NN
cord-048322-5eqdrd52	160	3	,	,	,
cord-048322-5eqdrd52	160	4	c	c	NN
cord-048322-5eqdrd52	160	5	)	)	-RRB-
cord-048322-5eqdrd52	161	1	In	in	IN
cord-048322-5eqdrd52	161	2	vivo	vivo	NN
cord-048322-5eqdrd52	161	3	delivery	delivery	NN
cord-048322-5eqdrd52	161	4	of	of	IN
cord-048322-5eqdrd52	161	5	intact	intact	JJ
cord-048322-5eqdrd52	161	6	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	161	7	upon	upon	IN
cord-048322-5eqdrd52	161	8	PEI	PEI	NNP
cord-048322-5eqdrd52	161	9	complexation	complexation	NN
cord-048322-5eqdrd52	161	10	.	.	.
cord-048322-5eqdrd52	162	1	[	[	-LRB-
cord-048322-5eqdrd52	162	2	32	32	CD
cord-048322-5eqdrd52	162	3	P]-labeled	P]-labeled	NNP
cord-048322-5eqdrd52	162	4	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	162	5	,	,	,
cord-048322-5eqdrd52	162	6	complexed	complexed	JJ
cord-048322-5eqdrd52	162	7	(	(	-LRB-
cord-048322-5eqdrd52	162	8	+	+	CC
cord-048322-5eqdrd52	162	9	)	)	-RRB-
cord-048322-5eqdrd52	162	10	or	or	CC
cord-048322-5eqdrd52	162	11	not	not	RB
cord-048322-5eqdrd52	162	12	complexed	complexed	JJ
cord-048322-5eqdrd52	162	13	(	(	-LRB-
cord-048322-5eqdrd52	162	14	−	−	NNP
cord-048322-5eqdrd52	162	15	)	)	-RRB-
cord-048322-5eqdrd52	162	16	with	with	IN
cord-048322-5eqdrd52	162	17	PEI	PEI	NNP
cord-048322-5eqdrd52	162	18	,	,	,
cord-048322-5eqdrd52	162	19	were	be	VBD
cord-048322-5eqdrd52	162	20	injected	inject	VBN
cord-048322-5eqdrd52	162	21	IP	ip	NN
cord-048322-5eqdrd52	162	22	into	into	IN
cord-048322-5eqdrd52	162	23	mice	mouse	NNS
cord-048322-5eqdrd52	162	24	bearing	bear	VBG
cord-048322-5eqdrd52	162	25	subcutaneous	subcutaneous	JJ
cord-048322-5eqdrd52	162	26	SKOV-3	SKOV-3	NNP
cord-048322-5eqdrd52	162	27	ovarian	ovarian	JJ
cord-048322-5eqdrd52	162	28	carcinoma	carcinoma	NN
cord-048322-5eqdrd52	162	29	cell	cell	NN
cord-048322-5eqdrd52	162	30	tumor	tumor	NN
cord-048322-5eqdrd52	162	31	xenografts	xenograft	NNS
cord-048322-5eqdrd52	162	32	,	,	,
cord-048322-5eqdrd52	162	33	and	and	CC
cord-048322-5eqdrd52	162	34	after	after	IN
cord-048322-5eqdrd52	162	35	30	30	CD
cord-048322-5eqdrd52	162	36	min	min	NN
cord-048322-5eqdrd52	162	37	(	(	-LRB-
cord-048322-5eqdrd52	162	38	b	b	NN
cord-048322-5eqdrd52	162	39	)	)	-RRB-
cord-048322-5eqdrd52	162	40	or	or	CC
cord-048322-5eqdrd52	162	41	4	4	CD
cord-048322-5eqdrd52	162	42	h	h	NN
cord-048322-5eqdrd52	162	43	(	(	-LRB-
cord-048322-5eqdrd52	162	44	b	b	NN
cord-048322-5eqdrd52	162	45	)	)	-RRB-
cord-048322-5eqdrd52	162	46	total	total	NN
cord-048322-5eqdrd52	162	47	RNA	RNA	NNP
cord-048322-5eqdrd52	162	48	from	from	IN
cord-048322-5eqdrd52	162	49	various	various	JJ
cord-048322-5eqdrd52	162	50	organ	organ	NN
cord-048322-5eqdrd52	162	51	and	and	CC
cord-048322-5eqdrd52	162	52	tissue	tissue	NN
cord-048322-5eqdrd52	162	53	homogenates	homogenate	NNS
cord-048322-5eqdrd52	162	54	was	be	VBD
cord-048322-5eqdrd52	162	55	prepared	prepare	VBN
cord-048322-5eqdrd52	162	56	and	and	CC
cord-048322-5eqdrd52	162	57	subjected	subject	VBN
cord-048322-5eqdrd52	162	58	to	to	IN
cord-048322-5eqdrd52	162	59	agarose	agarose	VBN
cord-048322-5eqdrd52	162	60	gel	gel	NN
cord-048322-5eqdrd52	162	61	electrophoresis	electrophoresis	NN
cord-048322-5eqdrd52	162	62	prior	prior	RB
cord-048322-5eqdrd52	162	63	to	to	IN
cord-048322-5eqdrd52	162	64	blotting	blotting	NN
cord-048322-5eqdrd52	162	65	and	and	CC
cord-048322-5eqdrd52	162	66	autoradiography	autoradiography	NN
cord-048322-5eqdrd52	162	67	.	.	.
cord-048322-5eqdrd52	163	1	The	the	DT
cord-048322-5eqdrd52	163	2	bands	band	NNS
cord-048322-5eqdrd52	163	3	represent	represent	VBP
cord-048322-5eqdrd52	163	4	intact	intact	JJ
cord-048322-5eqdrd52	163	5	[	[	-LRB-
cord-048322-5eqdrd52	163	6	32	32	CD
cord-048322-5eqdrd52	163	7	P]-labeled	P]-labeled	NNP
cord-048322-5eqdrd52	163	8	siRNA	siRNA	NNP
cord-048322-5eqdrd52	163	9	molecules	molecule	NNS
cord-048322-5eqdrd52	163	10	which	which	WDT
cord-048322-5eqdrd52	163	11	for	for	IN
cord-048322-5eqdrd52	163	12	several	several	JJ
cord-048322-5eqdrd52	163	13	hours	hour	NNS
cord-048322-5eqdrd52	163	14	are	be	VBP
cord-048322-5eqdrd52	163	15	mainly	mainly	RB
cord-048322-5eqdrd52	163	16	found	find	VBN
cord-048322-5eqdrd52	163	17	in	in	IN
cord-048322-5eqdrd52	163	18	tumor	tumor	NN
cord-048322-5eqdrd52	163	19	and	and	CC
cord-048322-5eqdrd52	163	20	muscle	muscle	NN
cord-048322-5eqdrd52	163	21	as	as	RB
cord-048322-5eqdrd52	163	22	well	well	RB
cord-048322-5eqdrd52	163	23	as	as	IN
cord-048322-5eqdrd52	163	24	in	in	IN
cord-048322-5eqdrd52	163	25	liver	liver	NN
cord-048322-5eqdrd52	163	26	and	and	CC
cord-048322-5eqdrd52	163	27	,	,	,
cord-048322-5eqdrd52	163	28	time	time	NN
cord-048322-5eqdrd52	163	29	-	-	HYPH
cord-048322-5eqdrd52	163	30	dependently	dependently	RB
cord-048322-5eqdrd52	163	31	,	,	,
cord-048322-5eqdrd52	163	32	in	in	IN
cord-048322-5eqdrd52	163	33	kidney	kidney	NN
cord-048322-5eqdrd52	163	34	.	.	.
cord-048322-5eqdrd52	164	1	Only	only	RB
cord-048322-5eqdrd52	164	2	little	little	JJ
cord-048322-5eqdrd52	164	3	siRNA	siRNA	NNP
cord-048322-5eqdrd52	164	4	amounts	amount	NNS
cord-048322-5eqdrd52	164	5	are	be	VBP
cord-048322-5eqdrd52	164	6	detected	detect	VBN
cord-048322-5eqdrd52	164	7	in	in	IN
cord-048322-5eqdrd52	164	8	the	the	DT
cord-048322-5eqdrd52	164	9	lung	lung	NN
cord-048322-5eqdrd52	164	10	and	and	CC
cord-048322-5eqdrd52	164	11	traces	trace	NNS
cord-048322-5eqdrd52	164	12	in	in	IN
cord-048322-5eqdrd52	164	13	the	the	DT
cord-048322-5eqdrd52	164	14	brain	brain	NN
cord-048322-5eqdrd52	164	15	.	.	.
cord-048322-5eqdrd52	165	1	previously	previously	RB
cord-048322-5eqdrd52	165	2	as	as	IN
cord-048322-5eqdrd52	165	3	"	"	``
cord-048322-5eqdrd52	165	4	rate	rate	NN
cord-048322-5eqdrd52	165	5	-	-	HYPH
cord-048322-5eqdrd52	165	6	limiting	limit	VBG
cord-048322-5eqdrd52	165	7	"	"	''
cord-048322-5eqdrd52	165	8	for	for	IN
cord-048322-5eqdrd52	165	9	tumor	tumor	NN
cord-048322-5eqdrd52	165	10	growth	growth	NN
cord-048322-5eqdrd52	165	11	and	and	CC
cord-048322-5eqdrd52	165	12	angiogenesis	angiogenesis	NN
cord-048322-5eqdrd52	165	13	in	in	IN
cord-048322-5eqdrd52	165	14	several	several	JJ
cord-048322-5eqdrd52	165	15	tumors	tumor	NNS
cord-048322-5eqdrd52	165	16	(	(	-LRB-
cord-048322-5eqdrd52	165	17	[	[	-LRB-
cord-048322-5eqdrd52	165	18	82	82	CD
cord-048322-5eqdrd52	165	19	,	,	,
cord-048322-5eqdrd52	165	20	83	83	CD
cord-048322-5eqdrd52	165	21	]	]	-RRB-
cord-048322-5eqdrd52	165	22	,	,	,
cord-048322-5eqdrd52	165	23	see	see	VBP
cord-048322-5eqdrd52	165	24	[	[	-LRB-
cord-048322-5eqdrd52	165	25	84	84	CD
cord-048322-5eqdrd52	165	26	]	]	-RRB-
cord-048322-5eqdrd52	165	27	for	for	IN
cord-048322-5eqdrd52	165	28	review	review	NN
cord-048322-5eqdrd52	165	29	)	)	-RRB-
cord-048322-5eqdrd52	165	30	.	.	.
cord-048322-5eqdrd52	166	1	Finally	finally	RB
cord-048322-5eqdrd52	166	2	,	,	,
cord-048322-5eqdrd52	166	3	PEI	PEI	NNP
cord-048322-5eqdrd52	166	4	/	/	SYM
cord-048322-5eqdrd52	166	5	siRNA	siRNA	NNP
cord-048322-5eqdrd52	166	6	-	-	HYPH
cord-048322-5eqdrd52	166	7	mediated	mediate	VBN
cord-048322-5eqdrd52	166	8	targeting	targeting	NN
cord-048322-5eqdrd52	166	9	of	of	IN
cord-048322-5eqdrd52	166	10	pleiotrophin	pleiotrophin	NNP
cord-048322-5eqdrd52	166	11	(	(	-LRB-
cord-048322-5eqdrd52	166	12	PTN	PTN	NNP
cord-048322-5eqdrd52	166	13	)	)	-RRB-
cord-048322-5eqdrd52	166	14	exerted	exert	VBD
cord-048322-5eqdrd52	166	15	strong	strong	JJ
cord-048322-5eqdrd52	166	16	antitumoral	antitumoral	JJ
cord-048322-5eqdrd52	166	17	effects	effect	NNS
cord-048322-5eqdrd52	166	18	.	.	.
cord-048322-5eqdrd52	167	1	PTN	PTN	NNP
cord-048322-5eqdrd52	167	2	is	be	VBZ
cord-048322-5eqdrd52	167	3	a	a	DT
cord-048322-5eqdrd52	167	4	secreted	secrete	VBN
cord-048322-5eqdrd52	167	5	growth	growth	NN
cord-048322-5eqdrd52	167	6	factor	factor	NN
cord-048322-5eqdrd52	167	7	which	which	WDT
cord-048322-5eqdrd52	167	8	shows	show	VBZ
cord-048322-5eqdrd52	167	9	mitogenic	mitogenic	NNP
cord-048322-5eqdrd52	167	10	,	,	,
cord-048322-5eqdrd52	167	11	chemotactic	chemotactic	JJ
cord-048322-5eqdrd52	167	12	,	,	,
cord-048322-5eqdrd52	167	13	angiogenic	angiogenic	JJ
cord-048322-5eqdrd52	167	14	and	and	CC
cord-048322-5eqdrd52	167	15	transforming	transform	VBG
cord-048322-5eqdrd52	167	16	activity	activity	NN
cord-048322-5eqdrd52	167	17	[	[	-LRB-
cord-048322-5eqdrd52	167	18	85	85	CD
cord-048322-5eqdrd52	167	19	]	]	-RRB-
cord-048322-5eqdrd52	168	1	[	[	-LRB-
cord-048322-5eqdrd52	168	2	86	86	CD
cord-048322-5eqdrd52	168	3	]	]	-RRB-
cord-048322-5eqdrd52	168	4	[	[	-LRB-
cord-048322-5eqdrd52	168	5	87	87	CD
cord-048322-5eqdrd52	168	6	]	]	-RRB-
cord-048322-5eqdrd52	168	7	[	[	-LRB-
cord-048322-5eqdrd52	168	8	88	88	CD
cord-048322-5eqdrd52	168	9	]	]	-RRB-
cord-048322-5eqdrd52	169	1	[	[	-LRB-
cord-048322-5eqdrd52	169	2	89	89	CD
cord-048322-5eqdrd52	169	3	]	]	-RRB-
cord-048322-5eqdrd52	170	1	[	[	-LRB-
cord-048322-5eqdrd52	170	2	90	90	CD
cord-048322-5eqdrd52	170	3	]	]	-RRB-
cord-048322-5eqdrd52	170	4	[	[	-LRB-
cord-048322-5eqdrd52	170	5	91	91	CD
cord-048322-5eqdrd52	170	6	]	]	-RRB-
cord-048322-5eqdrd52	170	7	[	[	-LRB-
cord-048322-5eqdrd52	170	8	92	92	CD
cord-048322-5eqdrd52	170	9	]	]	-RRB-
cord-048322-5eqdrd52	171	1	[	[	-LRB-
cord-048322-5eqdrd52	171	2	93	93	CD
cord-048322-5eqdrd52	171	3	]	]	-RRB-
cord-048322-5eqdrd52	171	4	and	and	CC
cord-048322-5eqdrd52	172	1	which	which	WDT
cord-048322-5eqdrd52	172	2	is	be	VBZ
cord-048322-5eqdrd52	172	3	markedly	markedly	RB
cord-048322-5eqdrd52	172	4	upregulated	upregulate	VBN
cord-048322-5eqdrd52	172	5	in	in	IN
cord-048322-5eqdrd52	172	6	several	several	JJ
cord-048322-5eqdrd52	172	7	human	human	JJ
cord-048322-5eqdrd52	172	8	tumors	tumor	NNS
cord-048322-5eqdrd52	172	9	including	include	VBG
cord-048322-5eqdrd52	172	10	cancer	cancer	NN
cord-048322-5eqdrd52	172	11	of	of	IN
cord-048322-5eqdrd52	172	12	the	the	DT
cord-048322-5eqdrd52	172	13	breast	breast	NN
cord-048322-5eqdrd52	172	14	,	,	,
cord-048322-5eqdrd52	172	15	testis	testis	NN
cord-048322-5eqdrd52	172	16	,	,	,
cord-048322-5eqdrd52	172	17	prostate	prostate	NN
cord-048322-5eqdrd52	172	18	,	,	,
cord-048322-5eqdrd52	172	19	pancreas	pancrea	NNS
cord-048322-5eqdrd52	172	20	,	,	,
cord-048322-5eqdrd52	172	21	and	and	CC
cord-048322-5eqdrd52	172	22	lung	lung	NN
cord-048322-5eqdrd52	172	23	as	as	RB
cord-048322-5eqdrd52	172	24	well	well	RB
cord-048322-5eqdrd52	172	25	as	as	IN
cord-048322-5eqdrd52	172	26	in	in	IN
cord-048322-5eqdrd52	172	27	melanomas	melanoma	NNS
cord-048322-5eqdrd52	172	28	,	,	,
cord-048322-5eqdrd52	172	29	meningiomas	meningiomas	NNP
cord-048322-5eqdrd52	172	30	,	,	,
cord-048322-5eqdrd52	172	31	neuroblastomas	neuroblastomas	NNP
cord-048322-5eqdrd52	172	32	,	,	,
cord-048322-5eqdrd52	172	33	and	and	CC
cord-048322-5eqdrd52	172	34	glioblastomas	glioblastomas	NNP
cord-048322-5eqdrd52	172	35	.	.	.
cord-048322-5eqdrd52	173	1	The	the	DT
cord-048322-5eqdrd52	173	2	in	in	IN
cord-048322-5eqdrd52	173	3	vivo	vivo	NN
cord-048322-5eqdrd52	173	4	treatment	treatment	NN
cord-048322-5eqdrd52	173	5	of	of	IN
cord-048322-5eqdrd52	173	6	nude	nude	JJ
cord-048322-5eqdrd52	173	7	mice	mouse	NNS
cord-048322-5eqdrd52	173	8	through	through	IN
cord-048322-5eqdrd52	173	9	systemic	systemic	JJ
cord-048322-5eqdrd52	173	10	subcutaneous	subcutaneous	JJ
cord-048322-5eqdrd52	173	11	or	or	CC
cord-048322-5eqdrd52	173	12	IP	ip	NN
cord-048322-5eqdrd52	173	13	application	application	NN
cord-048322-5eqdrd52	173	14	of	of	IN
cord-048322-5eqdrd52	173	15	PEI	PEI	NNP
cord-048322-5eqdrd52	173	16	-	-	HYPH
cord-048322-5eqdrd52	173	17	complexed	complexe	VBN
cord-048322-5eqdrd52	173	18	PTN	PTN	NNP
cord-048322-5eqdrd52	173	19	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	173	20	led	lead	VBD
cord-048322-5eqdrd52	173	21	to	to	IN
cord-048322-5eqdrd52	173	22	the	the	DT
cord-048322-5eqdrd52	173	23	delivery	delivery	NN
cord-048322-5eqdrd52	173	24	of	of	IN
cord-048322-5eqdrd52	173	25	intact	intact	JJ
cord-048322-5eqdrd52	173	26	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	173	27	into	into	IN
cord-048322-5eqdrd52	173	28	subcutaneous	subcutaneous	JJ
cord-048322-5eqdrd52	173	29	tumor	tumor	NN
cord-048322-5eqdrd52	173	30	xenografts	xenograft	NNS
cord-048322-5eqdrd52	173	31	and	and	CC
cord-048322-5eqdrd52	173	32	a	a	DT
cord-048322-5eqdrd52	173	33	significant	significant	JJ
cord-048322-5eqdrd52	173	34	inhibition	inhibition	NN
cord-048322-5eqdrd52	173	35	of	of	IN
cord-048322-5eqdrd52	173	36	tumor	tumor	NN
cord-048322-5eqdrd52	173	37	growth	growth	NN
cord-048322-5eqdrd52	173	38	.	.	.
cord-048322-5eqdrd52	174	1	Likewise	likewise	RB
cord-048322-5eqdrd52	174	2	,	,	,
cord-048322-5eqdrd52	174	3	in	in	IN
cord-048322-5eqdrd52	174	4	a	a	DT
cord-048322-5eqdrd52	174	5	clinically	clinically	RB
cord-048322-5eqdrd52	174	6	more	more	RBR
cord-048322-5eqdrd52	174	7	relevant	relevant	JJ
cord-048322-5eqdrd52	174	8	orthotopic	orthotopic	JJ
cord-048322-5eqdrd52	174	9	mouse	mouse	NN
cord-048322-5eqdrd52	174	10	glioblastoma	glioblastoma	NN
cord-048322-5eqdrd52	174	11	model	model	NN
cord-048322-5eqdrd52	174	12	with	with	IN
cord-048322-5eqdrd52	174	13	U87	U87	NNP
cord-048322-5eqdrd52	174	14	cells	cell	NNS
cord-048322-5eqdrd52	174	15	growing	grow	VBG
cord-048322-5eqdrd52	174	16	intracranially	intracranially	RB
cord-048322-5eqdrd52	174	17	,	,	,
cord-048322-5eqdrd52	174	18	the	the	DT
cord-048322-5eqdrd52	174	19	injection	injection	NN
cord-048322-5eqdrd52	174	20	of	of	IN
cord-048322-5eqdrd52	174	21	PEI	PEI	NNP
cord-048322-5eqdrd52	174	22	-	-	HYPH
cord-048322-5eqdrd52	174	23	complexed	complexe	VBN
cord-048322-5eqdrd52	174	24	PTN	PTN	NNP
cord-048322-5eqdrd52	174	25	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	174	26	into	into	IN
cord-048322-5eqdrd52	174	27	the	the	DT
cord-048322-5eqdrd52	174	28	CNS	CNS	NNP
cord-048322-5eqdrd52	174	29	exerted	exert	VBD
cord-048322-5eqdrd52	174	30	antitumoral	antitumoral	JJ
cord-048322-5eqdrd52	174	31	effects	effect	NNS
cord-048322-5eqdrd52	174	32	.	.	.
cord-048322-5eqdrd52	175	1	This	this	DT
cord-048322-5eqdrd52	175	2	establishes	establish	VBZ
cord-048322-5eqdrd52	175	3	,	,	,
cord-048322-5eqdrd52	175	4	also	also	RB
cord-048322-5eqdrd52	175	5	in	in	IN
cord-048322-5eqdrd52	175	6	a	a	DT
cord-048322-5eqdrd52	175	7	complex	complex	JJ
cord-048322-5eqdrd52	175	8	and	and	CC
cord-048322-5eqdrd52	175	9	relevant	relevant	JJ
cord-048322-5eqdrd52	175	10	orthotopic	orthotopic	JJ
cord-048322-5eqdrd52	175	11	tumor	tumor	NN
cord-048322-5eqdrd52	175	12	model	model	NN
cord-048322-5eqdrd52	175	13	,	,	,
cord-048322-5eqdrd52	175	14	the	the	DT
cord-048322-5eqdrd52	175	15	potential	potential	NN
cord-048322-5eqdrd52	175	16	of	of	IN
cord-048322-5eqdrd52	175	17	PEI	PEI	NNP
cord-048322-5eqdrd52	175	18	/	/	SYM
cord-048322-5eqdrd52	175	19	siRNA	siRNA	NNP
cord-048322-5eqdrd52	175	20	-	-	HYPH
cord-048322-5eqdrd52	175	21	mediated	mediate	VBN
cord-048322-5eqdrd52	175	22	PTN	PTN	NNP
cord-048322-5eqdrd52	175	23	gene	gene	NN
cord-048322-5eqdrd52	175	24	targeting	target	VBG
cord-048322-5eqdrd52	175	25	as	as	IN
cord-048322-5eqdrd52	175	26	a	a	DT
cord-048322-5eqdrd52	175	27	novel	novel	JJ
cord-048322-5eqdrd52	175	28	therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	175	29	option	option	NN
cord-048322-5eqdrd52	175	30	in	in	IN
cord-048322-5eqdrd52	175	31	GBM	GBM	NNP
cord-048322-5eqdrd52	175	32	,	,	,
cord-048322-5eqdrd52	175	33	and	and	CC
cord-048322-5eqdrd52	175	34	further	further	RB
cord-048322-5eqdrd52	175	35	extends	extend	VBZ
cord-048322-5eqdrd52	175	36	the	the	DT
cord-048322-5eqdrd52	175	37	modes	mode	NNS
cord-048322-5eqdrd52	175	38	of	of	IN
cord-048322-5eqdrd52	175	39	delivery	delivery	NN
cord-048322-5eqdrd52	175	40	of	of	IN
cord-048322-5eqdrd52	175	41	PEI	PEI	NNP
cord-048322-5eqdrd52	175	42	/	/	SYM
cord-048322-5eqdrd52	175	43	siRNA	siRNA	NNP
cord-048322-5eqdrd52	175	44	complexes	complex	NNS
cord-048322-5eqdrd52	175	45	intrathecal	intrathecal	JJ
cord-048322-5eqdrd52	175	46	strategies	strategy	NNS
cord-048322-5eqdrd52	175	47	as	as	IN
cord-048322-5eqdrd52	175	48	employed	employ	VBN
cord-048322-5eqdrd52	175	49	in	in	IN
cord-048322-5eqdrd52	175	50	the	the	DT
cord-048322-5eqdrd52	175	51	therapy	therapy	NN
cord-048322-5eqdrd52	175	52	of	of	IN
cord-048322-5eqdrd52	175	53	glioblastomas	glioblastomas	NNP
cord-048322-5eqdrd52	175	54	with	with	IN
cord-048322-5eqdrd52	175	55	antisense	antisense	NN
cord-048322-5eqdrd52	175	56	oligonucleotides	oligonucleotide	NNS
cord-048322-5eqdrd52	175	57	.	.	.
cord-048322-5eqdrd52	176	1	Only	only	RB
cord-048322-5eqdrd52	176	2	a	a	DT
cord-048322-5eqdrd52	176	3	few	few	JJ
cord-048322-5eqdrd52	176	4	years	year	NNS
cord-048322-5eqdrd52	176	5	after	after	IN
cord-048322-5eqdrd52	176	6	their	-PRON-	PRP$
cord-048322-5eqdrd52	176	7	discovery	discovery	NN
cord-048322-5eqdrd52	176	8	,	,	,
cord-048322-5eqdrd52	176	9	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	176	10	are	be	VBP
cord-048322-5eqdrd52	176	11	catching	catch	VBG
cord-048322-5eqdrd52	176	12	up	up	RP
cord-048322-5eqdrd52	176	13	with	with	IN
cord-048322-5eqdrd52	176	14	ribozymes	ribozyme	NNS
cord-048322-5eqdrd52	176	15	and	and	CC
cord-048322-5eqdrd52	176	16	antisense	antisense	NN
cord-048322-5eqdrd52	176	17	oligonucleotides	oligonucleotide	NNS
cord-048322-5eqdrd52	176	18	as	as	IN
cord-048322-5eqdrd52	176	19	efficient	efficient	JJ
cord-048322-5eqdrd52	176	20	tools	tool	NNS
cord-048322-5eqdrd52	176	21	for	for	IN
cord-048322-5eqdrd52	176	22	gene	gene	NN
cord-048322-5eqdrd52	176	23	targeting	targeting	NN
cord-048322-5eqdrd52	176	24	in	in	IN
cord-048322-5eqdrd52	176	25	vitro	vitro	FW
cord-048322-5eqdrd52	176	26	and	and	CC
cord-048322-5eqdrd52	176	27	,	,	,
cord-048322-5eqdrd52	176	28	more	more	RBR
cord-048322-5eqdrd52	176	29	recently	recently	RB
cord-048322-5eqdrd52	176	30	,	,	,
cord-048322-5eqdrd52	176	31	also	also	RB
cord-048322-5eqdrd52	176	32	in	in	IN
cord-048322-5eqdrd52	176	33	vivo	vivo	NNP
cord-048322-5eqdrd52	176	34	.	.	.
cord-048322-5eqdrd52	177	1	This	this	DT
cord-048322-5eqdrd52	177	2	includes	include	VBZ
cord-048322-5eqdrd52	177	3	the	the	DT
cord-048322-5eqdrd52	177	4	exploration	exploration	NN
cord-048322-5eqdrd52	177	5	of	of	IN
cord-048322-5eqdrd52	177	6	their	-PRON-	PRP$
cord-048322-5eqdrd52	177	7	potential	potential	NN
cord-048322-5eqdrd52	177	8	as	as	IN
cord-048322-5eqdrd52	177	9	therapeutics	therapeutic	NNS
cord-048322-5eqdrd52	177	10	which	which	WDT
cord-048322-5eqdrd52	177	11	will	will	MD
cord-048322-5eqdrd52	177	12	lead	lead	VB
cord-048322-5eqdrd52	177	13	to	to	IN
cord-048322-5eqdrd52	177	14	the	the	DT
cord-048322-5eqdrd52	177	15	development	development	NN
cord-048322-5eqdrd52	177	16	of	of	IN
cord-048322-5eqdrd52	177	17	siRNA	siRNA	NNP
cord-048322-5eqdrd52	177	18	-	-	HYPH
cord-048322-5eqdrd52	177	19	based	base	VBN
cord-048322-5eqdrd52	177	20	therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	177	21	strategies	strategy	NNS
cord-048322-5eqdrd52	177	22	.	.	.
cord-048322-5eqdrd52	178	1	Their	-PRON-	PRP$
cord-048322-5eqdrd52	178	2	ultimate	ultimate	JJ
cord-048322-5eqdrd52	178	3	success	success	NN
cord-048322-5eqdrd52	178	4	,	,	,
cord-048322-5eqdrd52	178	5	however	however	RB
cord-048322-5eqdrd52	178	6	,	,	,
cord-048322-5eqdrd52	178	7	will	will	MD
cord-048322-5eqdrd52	178	8	Figure	figure	VB
cord-048322-5eqdrd52	178	9	4	4	CD
cord-048322-5eqdrd52	178	10	:	:	:
cord-048322-5eqdrd52	178	11	Systemic	systemic	JJ
cord-048322-5eqdrd52	178	12	treatment	treatment	NN
cord-048322-5eqdrd52	178	13	of	of	IN
cord-048322-5eqdrd52	178	14	mice	mouse	NNS
cord-048322-5eqdrd52	178	15	with	with	IN
cord-048322-5eqdrd52	178	16	PEI	PEI	NNP
cord-048322-5eqdrd52	178	17	-	-	HYPH
cord-048322-5eqdrd52	178	18	complexed	complexe	VBN
cord-048322-5eqdrd52	178	19	HER-2-specific	HER-2-specific	NNP
cord-048322-5eqdrd52	178	20	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	178	21	leads	lead	VBZ
cord-048322-5eqdrd52	178	22	to	to	IN
cord-048322-5eqdrd52	178	23	reduced	reduce	VBN
cord-048322-5eqdrd52	178	24	growth	growth	NN
cord-048322-5eqdrd52	178	25	of	of	IN
cord-048322-5eqdrd52	178	26	subcutaneous	subcutaneous	JJ
cord-048322-5eqdrd52	178	27	SKOV-3	SKOV-3	NNP
cord-048322-5eqdrd52	178	28	tumor	tumor	NN
cord-048322-5eqdrd52	178	29	xenografts	xenograft	NNS
cord-048322-5eqdrd52	178	30	due	due	JJ
cord-048322-5eqdrd52	178	31	to	to	IN
cord-048322-5eqdrd52	178	32	decreased	decrease	VBD
cord-048322-5eqdrd52	178	33	HER-2	HER-2	NNP
cord-048322-5eqdrd52	178	34	expression	expression	NN
cord-048322-5eqdrd52	178	35	.	.	.
cord-048322-5eqdrd52	179	1	In	in	IN
cord-048322-5eqdrd52	179	2	[	[	-LRB-
cord-048322-5eqdrd52	179	3	70	70	CD
cord-048322-5eqdrd52	179	4	]	]	-RRB-
cord-048322-5eqdrd52	179	5	athymic	athymic	JJ
cord-048322-5eqdrd52	179	6	nude	nude	JJ
cord-048322-5eqdrd52	179	7	mice	mouse	NNS
cord-048322-5eqdrd52	179	8	bearing	bear	VBG
cord-048322-5eqdrd52	179	9	subcutaneous	subcutaneous	JJ
cord-048322-5eqdrd52	179	10	tumor	tumor	NN
cord-048322-5eqdrd52	179	11	xenografts	xenograft	NNS
cord-048322-5eqdrd52	179	12	were	be	VBD
cord-048322-5eqdrd52	179	13	injected	inject	VBN
cord-048322-5eqdrd52	179	14	IP	ip	NN
cord-048322-5eqdrd52	179	15	with	with	IN
cord-048322-5eqdrd52	179	16	0.6	0.6	CD
cord-048322-5eqdrd52	179	17	nmoles	nmole	NNS
cord-048322-5eqdrd52	179	18	HER-2-specific	HER-2-specific	NNP
cord-048322-5eqdrd52	179	19	naked	naked	JJ
cord-048322-5eqdrd52	179	20	(	(	-LRB-
cord-048322-5eqdrd52	179	21	open	open	JJ
cord-048322-5eqdrd52	179	22	circles	circle	NNS
cord-048322-5eqdrd52	179	23	)	)	-RRB-
cord-048322-5eqdrd52	179	24	or	or	CC
cord-048322-5eqdrd52	179	25	PEI	PEI	NNP
cord-048322-5eqdrd52	179	26	-	-	HYPH
cord-048322-5eqdrd52	179	27	complexed	complexed	NNP
cord-048322-5eqdrd52	179	28	(	(	-LRB-
cord-048322-5eqdrd52	179	29	closed	closed	JJ
cord-048322-5eqdrd52	179	30	circles	circle	NNS
cord-048322-5eqdrd52	179	31	)	)	-RRB-
cord-048322-5eqdrd52	180	1	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	180	2	2	2	CD
cord-048322-5eqdrd52	180	3	-	-	SYM
cord-048322-5eqdrd52	180	4	3	3	CD
cord-048322-5eqdrd52	180	5	times	time	NNS
cord-048322-5eqdrd52	180	6	per	per	IN
cord-048322-5eqdrd52	180	7	week	week	NN
cord-048322-5eqdrd52	180	8	and	and	CC
cord-048322-5eqdrd52	180	9	tumor	tumor	NN
cord-048322-5eqdrd52	180	10	sizes	size	NNS
cord-048322-5eqdrd52	180	11	were	be	VBD
cord-048322-5eqdrd52	180	12	evaluated	evaluate	VBN
cord-048322-5eqdrd52	180	13	daily	daily	RB
cord-048322-5eqdrd52	180	14	from	from	IN
cord-048322-5eqdrd52	180	15	the	the	DT
cord-048322-5eqdrd52	180	16	product	product	NN
cord-048322-5eqdrd52	180	17	of	of	IN
cord-048322-5eqdrd52	180	18	the	the	DT
cord-048322-5eqdrd52	180	19	perpendicular	perpendicular	JJ
cord-048322-5eqdrd52	180	20	diameters	diameter	NNS
cord-048322-5eqdrd52	180	21	of	of	IN
cord-048322-5eqdrd52	180	22	the	the	DT
cord-048322-5eqdrd52	180	23	tumors	tumor	NNS
cord-048322-5eqdrd52	180	24	.	.	.
cord-048322-5eqdrd52	181	1	Mean	mean	JJ
cord-048322-5eqdrd52	181	2	+	+	CC
cord-048322-5eqdrd52	182	1	/-standard	/-standard	NFP
cord-048322-5eqdrd52	182	2	error	error	NN
cord-048322-5eqdrd52	182	3	of	of	IN
cord-048322-5eqdrd52	182	4	the	the	DT
cord-048322-5eqdrd52	182	5	mean	mean	JJ
cord-048322-5eqdrd52	182	6	(	(	-LRB-
cord-048322-5eqdrd52	182	7	SEM	SEM	NNP
cord-048322-5eqdrd52	182	8	)	)	-RRB-
cord-048322-5eqdrd52	182	9	is	be	VBZ
cord-048322-5eqdrd52	182	10	depicted	depict	VBN
cord-048322-5eqdrd52	182	11	and	and	CC
cord-048322-5eqdrd52	182	12	Student	Student	NNP
cord-048322-5eqdrd52	182	13	's	's	POS
cord-048322-5eqdrd52	182	14	unpaired	unpaired	JJ
cord-048322-5eqdrd52	182	15	t	t	NN
cord-048322-5eqdrd52	182	16	test	test	NN
cord-048322-5eqdrd52	182	17	was	be	VBD
cord-048322-5eqdrd52	182	18	used	use	VBN
cord-048322-5eqdrd52	182	19	for	for	IN
cord-048322-5eqdrd52	182	20	comparisons	comparison	NNS
cord-048322-5eqdrd52	182	21	between	between	IN
cord-048322-5eqdrd52	182	22	data	data	NN
cord-048322-5eqdrd52	182	23	sets	set	NNS
cord-048322-5eqdrd52	182	24	(	(	-LRB-
cord-048322-5eqdrd52	182	25	*	*	NFP
cord-048322-5eqdrd52	182	26	*	*	NFP
cord-048322-5eqdrd52	182	27	P	p	NN
cord-048322-5eqdrd52	182	28	<	<	XX
cord-048322-5eqdrd52	182	29	.03	.03	NFP
cord-048322-5eqdrd52	182	30	,	,	.
cord-048322-5eqdrd52	183	1	*	*	NFP
cord-048322-5eqdrd52	183	2	*	*	NFP
cord-048322-5eqdrd52	183	3	*	*	NFP
cord-048322-5eqdrd52	183	4	P	p	NN
cord-048322-5eqdrd52	183	5	<	<	XX
cord-048322-5eqdrd52	183	6	.01	.01	NFP
cord-048322-5eqdrd52	183	7	)	)	-RRB-
cord-048322-5eqdrd52	183	8	.	.	.
cord-048322-5eqdrd52	184	1	Differences	difference	NNS
cord-048322-5eqdrd52	184	2	in	in	IN
cord-048322-5eqdrd52	184	3	tumor	tumor	NN
cord-048322-5eqdrd52	184	4	growth	growth	NN
cord-048322-5eqdrd52	184	5	reach	reach	VBP
cord-048322-5eqdrd52	184	6	significance	significance	NN
cord-048322-5eqdrd52	184	7	at	at	IN
cord-048322-5eqdrd52	184	8	day	day	NN
cord-048322-5eqdrd52	184	9	5	5	CD
cord-048322-5eqdrd52	184	10	indicating	indicate	VBG
cord-048322-5eqdrd52	184	11	the	the	DT
cord-048322-5eqdrd52	184	12	antitumoral	antitumoral	JJ
cord-048322-5eqdrd52	184	13	effects	effect	NNS
cord-048322-5eqdrd52	184	14	of	of	IN
cord-048322-5eqdrd52	184	15	the	the	DT
cord-048322-5eqdrd52	184	16	PEI	PEI	NNP
cord-048322-5eqdrd52	184	17	-	-	HYPH
cord-048322-5eqdrd52	184	18	complexed	complexe	VBN
cord-048322-5eqdrd52	184	19	HER-2-specific	HER-2-specific	NNP
cord-048322-5eqdrd52	184	20	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	184	21	.	.	.
cord-048322-5eqdrd52	185	1	strongly	strongly	RB
cord-048322-5eqdrd52	185	2	depend	depend	VB
cord-048322-5eqdrd52	185	3	on	on	IN
cord-048322-5eqdrd52	185	4	the	the	DT
cord-048322-5eqdrd52	185	5	development	development	NN
cord-048322-5eqdrd52	185	6	of	of	IN
cord-048322-5eqdrd52	185	7	powerful	powerful	JJ
cord-048322-5eqdrd52	185	8	and	and	CC
cord-048322-5eqdrd52	185	9	feasible	feasible	JJ
cord-048322-5eqdrd52	185	10	siRNA	siRNA	NNP
cord-048322-5eqdrd52	185	11	delivery	delivery	NN
cord-048322-5eqdrd52	185	12	strategies	strategy	NNS
cord-048322-5eqdrd52	185	13	which	which	WDT
cord-048322-5eqdrd52	185	14	need	need	VBP
cord-048322-5eqdrd52	185	15	to	to	TO
cord-048322-5eqdrd52	185	16	address	address	VB
cord-048322-5eqdrd52	185	17	several	several	JJ
cord-048322-5eqdrd52	185	18	issues	issue	NNS
cord-048322-5eqdrd52	185	19	including	include	VBG
cord-048322-5eqdrd52	185	20	the	the	DT
cord-048322-5eqdrd52	185	21	stability	stability	NN
cord-048322-5eqdrd52	185	22	/	/	SYM
cord-048322-5eqdrd52	185	23	stabilization	stabilization	NN
cord-048322-5eqdrd52	185	24	of	of	IN
cord-048322-5eqdrd52	185	25	siRNA	siRNA	NNP
cord-048322-5eqdrd52	185	26	molecules	molecule	NNS
cord-048322-5eqdrd52	185	27	while	while	IN
cord-048322-5eqdrd52	185	28	preserving	preserve	VBG
cord-048322-5eqdrd52	185	29	their	-PRON-	PRP$
cord-048322-5eqdrd52	185	30	efficacy	efficacy	NN
cord-048322-5eqdrd52	185	31	and	and	CC
cord-048322-5eqdrd52	185	32	maintaining	maintain	VBG
cord-048322-5eqdrd52	185	33	their	-PRON-	PRP$
cord-048322-5eqdrd52	185	34	genesilencing	genesilence	VBG
cord-048322-5eqdrd52	185	35	activity	activity	NN
cord-048322-5eqdrd52	185	36	,	,	,
cord-048322-5eqdrd52	185	37	an	an	DT
cord-048322-5eqdrd52	185	38	efficient	efficient	JJ
cord-048322-5eqdrd52	185	39	delivery	delivery	NN
cord-048322-5eqdrd52	185	40	into	into	IN
cord-048322-5eqdrd52	185	41	the	the	DT
cord-048322-5eqdrd52	185	42	target	target	NN
cord-048322-5eqdrd52	186	1	organ(s	organ(s	NNP
cord-048322-5eqdrd52	186	2	)	)	-RRB-
cord-048322-5eqdrd52	186	3	as	as	RB
cord-048322-5eqdrd52	186	4	well	well	RB
cord-048322-5eqdrd52	186	5	as	as	IN
cord-048322-5eqdrd52	186	6	a	a	DT
cord-048322-5eqdrd52	186	7	sufficiently	sufficiently	RB
cord-048322-5eqdrd52	186	8	long	long	JJ
cord-048322-5eqdrd52	186	9	siRNA	siRNA	NNP
cord-048322-5eqdrd52	186	10	half	half	JJ
cord-048322-5eqdrd52	186	11	life	life	NN
cord-048322-5eqdrd52	186	12	in	in	IN
cord-048322-5eqdrd52	186	13	the	the	DT
cord-048322-5eqdrd52	186	14	organism	organism	NN
cord-048322-5eqdrd52	186	15	and	and	CC
cord-048322-5eqdrd52	186	16	particularly	particularly	RB
cord-048322-5eqdrd52	186	17	in	in	IN
cord-048322-5eqdrd52	186	18	the	the	DT
cord-048322-5eqdrd52	186	19	target	target	NN
cord-048322-5eqdrd52	186	20	organ	organ	NN
cord-048322-5eqdrd52	186	21	.	.	.
cord-048322-5eqdrd52	187	1	Thus	thus	RB
cord-048322-5eqdrd52	187	2	,	,	,
cord-048322-5eqdrd52	187	3	siRNA	siRNA	NNP
cord-048322-5eqdrd52	187	4	delivery	delivery	NN
cord-048322-5eqdrd52	187	5	strategies	strategy	NNS
cord-048322-5eqdrd52	187	6	must	must	MD
cord-048322-5eqdrd52	187	7	provide	provide	VB
cord-048322-5eqdrd52	187	8	siRNA	siRNA	NNP
cord-048322-5eqdrd52	187	9	protection	protection	NN
cord-048322-5eqdrd52	187	10	and	and	CC
cord-048322-5eqdrd52	187	11	transfection	transfection	NN
cord-048322-5eqdrd52	187	12	efficacy	efficacy	NN
cord-048322-5eqdrd52	187	13	,	,	,
cord-048322-5eqdrd52	187	14	the	the	DT
cord-048322-5eqdrd52	187	15	absence	absence	NN
cord-048322-5eqdrd52	187	16	of	of	IN
cord-048322-5eqdrd52	187	17	toxic	toxic	JJ
cord-048322-5eqdrd52	187	18	and	and	CC
cord-048322-5eqdrd52	187	19	nonspecific	nonspecific	JJ
cord-048322-5eqdrd52	187	20	effects	effect	NNS
cord-048322-5eqdrd52	187	21	,	,	,
cord-048322-5eqdrd52	187	22	they	-PRON-	PRP
cord-048322-5eqdrd52	187	23	must	must	MD
cord-048322-5eqdrd52	187	24	be	be	VB
cord-048322-5eqdrd52	187	25	efficacious	efficacious	JJ
cord-048322-5eqdrd52	187	26	also	also	RB
cord-048322-5eqdrd52	187	27	when	when	WRB
cord-048322-5eqdrd52	187	28	using	use	VBG
cord-048322-5eqdrd52	187	29	small	small	JJ
cord-048322-5eqdrd52	187	30	amounts	amount	NNS
cord-048322-5eqdrd52	187	31	of	of	IN
cord-048322-5eqdrd52	187	32	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	187	33	and	and	CC
cord-048322-5eqdrd52	187	34	must	must	MD
cord-048322-5eqdrd52	187	35	be	be	VB
cord-048322-5eqdrd52	187	36	applicable	applicable	JJ
cord-048322-5eqdrd52	187	37	in	in	IN
cord-048322-5eqdrd52	187	38	various	various	JJ
cord-048322-5eqdrd52	187	39	treatment	treatment	NN
cord-048322-5eqdrd52	187	40	regimens	regimen	NNS
cord-048322-5eqdrd52	187	41	and	and	CC
cord-048322-5eqdrd52	187	42	in	in	IN
cord-048322-5eqdrd52	187	43	various	various	JJ
cord-048322-5eqdrd52	187	44	diseases	disease	NNS
cord-048322-5eqdrd52	187	45	even	even	RB
cord-048322-5eqdrd52	187	46	when	when	WRB
cord-048322-5eqdrd52	187	47	this	this	DT
cord-048322-5eqdrd52	187	48	requires	require	VBZ
cord-048322-5eqdrd52	187	49	to	to	TO
cord-048322-5eqdrd52	187	50	overcome	overcome	VB
cord-048322-5eqdrd52	187	51	biological	biological	JJ
cord-048322-5eqdrd52	187	52	barriers	barrier	NNS
cord-048322-5eqdrd52	187	53	after	after	IN
cord-048322-5eqdrd52	187	54	their	-PRON-	PRP$
cord-048322-5eqdrd52	187	55	administration	administration	NN
cord-048322-5eqdrd52	187	56	to	to	TO
cord-048322-5eqdrd52	187	57	reach	reach	VB
cord-048322-5eqdrd52	187	58	their	-PRON-	PRP$
cord-048322-5eqdrd52	187	59	target	target	NN
cord-048322-5eqdrd52	187	60	tissue	tissue	NN
cord-048322-5eqdrd52	187	61	or	or	CC
cord-048322-5eqdrd52	187	62	target	target	NN
cord-048322-5eqdrd52	187	63	organ	organ	NN
cord-048322-5eqdrd52	187	64	.	.	.
cord-048322-5eqdrd52	188	1	The	the	DT
cord-048322-5eqdrd52	188	2	research	research	NN
cord-048322-5eqdrd52	188	3	done	do	VBN
cord-048322-5eqdrd52	188	4	on	on	IN
cord-048322-5eqdrd52	188	5	DNA	dna	NN
cord-048322-5eqdrd52	188	6	-	-	HYPH
cord-048322-5eqdrd52	188	7	based	base	VBN
cord-048322-5eqdrd52	188	8	gene	gene	NN
cord-048322-5eqdrd52	188	9	delivery	delivery	NN
cord-048322-5eqdrd52	188	10	,	,	,
cord-048322-5eqdrd52	188	11	ribozyme	ribozyme	NN
cord-048322-5eqdrd52	188	12	-	-	HYPH
cord-048322-5eqdrd52	188	13	targeting	targeting	NN
cord-048322-5eqdrd52	188	14	,	,	,
cord-048322-5eqdrd52	188	15	and	and	CC
cord-048322-5eqdrd52	188	16	antisense	antisense	NN
cord-048322-5eqdrd52	188	17	technology	technology	NN
cord-048322-5eqdrd52	188	18	will	will	MD
cord-048322-5eqdrd52	188	19	facilitate	facilitate	VB
cord-048322-5eqdrd52	188	20	this	this	DT
cord-048322-5eqdrd52	188	21	process	process	NN
cord-048322-5eqdrd52	188	22	since	since	IN
cord-048322-5eqdrd52	188	23	it	-PRON-	PRP
cord-048322-5eqdrd52	188	24	already	already	RB
cord-048322-5eqdrd52	188	25	provides	provide	VBZ
cord-048322-5eqdrd52	188	26	a	a	DT
cord-048322-5eqdrd52	188	27	basis	basis	NN
cord-048322-5eqdrd52	188	28	of	of	IN
cord-048322-5eqdrd52	188	29	established	establish	VBN
cord-048322-5eqdrd52	188	30	technologies	technology	NNS
cord-048322-5eqdrd52	188	31	.	.	.
cord-048322-5eqdrd52	189	1	This	this	DT
cord-048322-5eqdrd52	189	2	is	be	VBZ
cord-048322-5eqdrd52	189	3	also	also	RB
cord-048322-5eqdrd52	189	4	true	true	JJ
cord-048322-5eqdrd52	189	5	for	for	IN
cord-048322-5eqdrd52	189	6	the	the	DT
cord-048322-5eqdrd52	189	7	complexation	complexation	NN
cord-048322-5eqdrd52	189	8	of	of	IN
cord-048322-5eqdrd52	189	9	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	189	10	with	with	IN
cord-048322-5eqdrd52	189	11	polyethylenimine	polyethylenimine	NNP
cord-048322-5eqdrd52	189	12	,	,	,
cord-048322-5eqdrd52	189	13	which	which	WDT
cord-048322-5eqdrd52	189	14	may	may	MD
cord-048322-5eqdrd52	189	15	represent	represent	VB
cord-048322-5eqdrd52	189	16	a	a	DT
cord-048322-5eqdrd52	189	17	promising	promising	JJ
cord-048322-5eqdrd52	189	18	avenue	avenue	NN
cord-048322-5eqdrd52	189	19	for	for	IN
cord-048322-5eqdrd52	189	20	siRNA	siRNA	NNP
cord-048322-5eqdrd52	189	21	applications	application	NNS
cord-048322-5eqdrd52	189	22	in	in	IN
cord-048322-5eqdrd52	189	23	vivo	vivo	NN
cord-048322-5eqdrd52	189	24	.	.	.
cord-048322-5eqdrd52	190	1	This	this	DT
cord-048322-5eqdrd52	190	2	may	may	MD
cord-048322-5eqdrd52	190	3	eventually	eventually	RB
cord-048322-5eqdrd52	190	4	lead	lead	VB
cord-048322-5eqdrd52	190	5	to	to	IN
cord-048322-5eqdrd52	190	6	novel	novel	JJ
cord-048322-5eqdrd52	190	7	therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	190	8	strategies	strategy	NNS
cord-048322-5eqdrd52	190	9	.	.	.
cord-048322-5eqdrd52	190	10	 	 	_SP
cord-048322-5eqdrd52	191	1	The	the	DT
cord-048322-5eqdrd52	191	2	work	work	NN
cord-048322-5eqdrd52	191	3	of	of	IN
cord-048322-5eqdrd52	191	4	A.	a.	NN
cord-048322-5eqdrd52	191	5	Aigner	Aigner	NNP
cord-048322-5eqdrd52	191	6	is	be	VBZ
cord-048322-5eqdrd52	191	7	supported	support	VBN
cord-048322-5eqdrd52	191	8	by	by	IN
cord-048322-5eqdrd52	191	9	the	the	DT
cord-048322-5eqdrd52	191	10	Deutsche	Deutsche	NNP
cord-048322-5eqdrd52	191	11	Forschungsgemeinschaft	Forschungsgemeinschaft	NNP
cord-048322-5eqdrd52	191	12	(	(	-LRB-
cord-048322-5eqdrd52	191	13	AI	AI	NNP
cord-048322-5eqdrd52	191	14	24/5	24/5	NN
cord-048322-5eqdrd52	191	15	-	-	HYPH
cord-048322-5eqdrd52	191	16	1	1	CD
cord-048322-5eqdrd52	191	17	)	)	-RRB-
cord-048322-5eqdrd52	191	18	and	and	CC
cord-048322-5eqdrd52	191	19	by	by	IN
cord-048322-5eqdrd52	191	20	the	the	DT
cord-048322-5eqdrd52	191	21	Deutsche	Deutsche	NNP
cord-048322-5eqdrd52	191	22	Krebshilfe	Krebshilfe	NNP
cord-048322-5eqdrd52	191	23	.	.	.
cord-048322-5eqdrd52	192	1	The	the	DT
cord-048322-5eqdrd52	192	2	author	author	NN
cord-048322-5eqdrd52	192	3	would	would	MD
cord-048322-5eqdrd52	192	4	like	like	VB
cord-048322-5eqdrd52	192	5	to	to	TO
cord-048322-5eqdrd52	192	6	apologize	apologize	VB
cord-048322-5eqdrd52	192	7	to	to	IN
cord-048322-5eqdrd52	192	8	the	the	DT
cord-048322-5eqdrd52	192	9	authors	author	NNS
cord-048322-5eqdrd52	192	10	whose	whose	WP$
cord-048322-5eqdrd52	192	11	primary	primary	JJ
cord-048322-5eqdrd52	192	12	works	work	NNS
cord-048322-5eqdrd52	192	13	have	have	VBP
cord-048322-5eqdrd52	192	14	not	not	RB
cord-048322-5eqdrd52	192	15	been	be	VBN
cord-048322-5eqdrd52	192	16	cited	cite	VBN
cord-048322-5eqdrd52	192	17	due	due	IN
cord-048322-5eqdrd52	192	18	to	to	IN
cord-048322-5eqdrd52	192	19	length	length	NN
cord-048322-5eqdrd52	192	20	considerations	consideration	NNS
cord-048322-5eqdrd52	192	21	.	.	.
cord-048322-5eqdrd52	193	1	Inhibition	inhibition	NN
cord-048322-5eqdrd52	193	2	of	of	IN
cord-048322-5eqdrd52	193	3	Rous	rous	JJ
cord-048322-5eqdrd52	193	4	sarcoma	sarcoma	NN
cord-048322-5eqdrd52	193	5	viral	viral	JJ
cord-048322-5eqdrd52	193	6	RNA	RNA	NNP
cord-048322-5eqdrd52	193	7	translation	translation	NN
cord-048322-5eqdrd52	193	8	by	by	IN
cord-048322-5eqdrd52	193	9	a	a	DT
cord-048322-5eqdrd52	193	10	specific	specific	JJ
cord-048322-5eqdrd52	193	11	oligodeoxyribonucleotide	oligodeoxyribonucleotide	NN
cord-048322-5eqdrd52	193	12	Inhibition	inhibition	NN
cord-048322-5eqdrd52	193	13	of	of	IN
cord-048322-5eqdrd52	193	14	Rous	rous	JJ
cord-048322-5eqdrd52	193	15	sarcoma	sarcoma	NN
cord-048322-5eqdrd52	193	16	virus	virus	NN
cord-048322-5eqdrd52	193	17	replication	replication	NN
cord-048322-5eqdrd52	193	18	and	and	CC
cord-048322-5eqdrd52	193	19	cell	cell	NN
cord-048322-5eqdrd52	193	20	transformation	transformation	NN
cord-048322-5eqdrd52	193	21	by	by	IN
cord-048322-5eqdrd52	193	22	a	a	DT
cord-048322-5eqdrd52	193	23	specific	specific	JJ
cord-048322-5eqdrd52	193	24	oligodeoxynucleotide	oligodeoxynucleotide	NN
cord-048322-5eqdrd52	194	1	In	in	IN
cord-048322-5eqdrd52	194	2	vitro	vitro	FW
cord-048322-5eqdrd52	194	3	splicing	splicing	NN
cord-048322-5eqdrd52	194	4	of	of	IN
cord-048322-5eqdrd52	194	5	the	the	DT
cord-048322-5eqdrd52	194	6	ribosomal	ribosomal	JJ
cord-048322-5eqdrd52	194	7	RNA	RNA	NNP
cord-048322-5eqdrd52	194	8	precursor	precursor	NN
cord-048322-5eqdrd52	194	9	of	of	IN
cord-048322-5eqdrd52	194	10	Tetrahymena	Tetrahymena	NNP
cord-048322-5eqdrd52	194	11	:	:	:
cord-048322-5eqdrd52	194	12	involvement	involvement	NN
cord-048322-5eqdrd52	194	13	of	of	IN
cord-048322-5eqdrd52	194	14	a	a	DT
cord-048322-5eqdrd52	194	15	guanosine	guanosine	NN
cord-048322-5eqdrd52	194	16	nucleotide	nucleotide	NN
cord-048322-5eqdrd52	194	17	in	in	IN
cord-048322-5eqdrd52	194	18	the	the	DT
cord-048322-5eqdrd52	194	19	excision	excision	NN
cord-048322-5eqdrd52	194	20	of	of	IN
cord-048322-5eqdrd52	194	21	the	the	DT
cord-048322-5eqdrd52	194	22	intervening	intervene	VBG
cord-048322-5eqdrd52	194	23	sequence	sequence	NN
cord-048322-5eqdrd52	194	24	Self	self	NN
cord-048322-5eqdrd52	194	25	-	-	HYPH
cord-048322-5eqdrd52	194	26	splicing	splice	VBG
cord-048322-5eqdrd52	194	27	RNA	rna	NN
cord-048322-5eqdrd52	194	28	:	:	:
cord-048322-5eqdrd52	194	29	autoexcision	autoexcision	NN
cord-048322-5eqdrd52	194	30	and	and	CC
cord-048322-5eqdrd52	194	31	autocyclization	autocyclization	NN
cord-048322-5eqdrd52	194	32	of	of	IN
cord-048322-5eqdrd52	194	33	the	the	DT
cord-048322-5eqdrd52	194	34	ribosomal	ribosomal	JJ
cord-048322-5eqdrd52	194	35	RNA	RNA	NNP
cord-048322-5eqdrd52	194	36	intervening	intervene	VBG
cord-048322-5eqdrd52	194	37	sequence	sequence	NN
cord-048322-5eqdrd52	194	38	of	of	IN
cord-048322-5eqdrd52	194	39	Tetrahymena	Tetrahymena	NNP
cord-048322-5eqdrd52	194	40	The	the	DT
cord-048322-5eqdrd52	194	41	RNA	RNA	NNP
cord-048322-5eqdrd52	194	42	moiety	moiety	NN
cord-048322-5eqdrd52	194	43	of	of	IN
cord-048322-5eqdrd52	194	44	ribonuclease	ribonuclease	NN
cord-048322-5eqdrd52	194	45	P	p	NN
cord-048322-5eqdrd52	194	46	is	be	VBZ
cord-048322-5eqdrd52	194	47	the	the	DT
cord-048322-5eqdrd52	194	48	catalytic	catalytic	JJ
cord-048322-5eqdrd52	194	49	subunit	subunit	NN
cord-048322-5eqdrd52	194	50	of	of	IN
cord-048322-5eqdrd52	194	51	the	the	DT
cord-048322-5eqdrd52	194	52	enzyme	enzyme	NN
cord-048322-5eqdrd52	194	53	Potent	potent	JJ
cord-048322-5eqdrd52	194	54	and	and	CC
cord-048322-5eqdrd52	194	55	specific	specific	JJ
cord-048322-5eqdrd52	194	56	genetic	genetic	JJ
cord-048322-5eqdrd52	194	57	interference	interference	NN
cord-048322-5eqdrd52	194	58	by	by	IN
cord-048322-5eqdrd52	194	59	double	double	RB
cord-048322-5eqdrd52	194	60	-	-	HYPH
cord-048322-5eqdrd52	194	61	stranded	strand	VBN
cord-048322-5eqdrd52	194	62	RNA	RNA	NNP
cord-048322-5eqdrd52	194	63	in	in	IN
cord-048322-5eqdrd52	194	64	caenorhabditis	caenorhabditis	NNP
cord-048322-5eqdrd52	195	1	elegans	elegan	NNS
cord-048322-5eqdrd52	195	2	Altered	altered	JJ
cord-048322-5eqdrd52	195	3	gene	gene	NN
cord-048322-5eqdrd52	195	4	expression	expression	NN
cord-048322-5eqdrd52	195	5	in	in	IN
cord-048322-5eqdrd52	195	6	plants	plant	NNS
cord-048322-5eqdrd52	195	7	due	due	JJ
cord-048322-5eqdrd52	195	8	to	to	IN
cord-048322-5eqdrd52	195	9	trans	trans	JJ
cord-048322-5eqdrd52	195	10	interactions	interaction	NNS
cord-048322-5eqdrd52	195	11	between	between	IN
cord-048322-5eqdrd52	195	12	homologous	homologous	JJ
cord-048322-5eqdrd52	195	13	genes	gene	NNS
cord-048322-5eqdrd52	195	14	par-1	par-1	NNP
cord-048322-5eqdrd52	195	15	,	,	,
cord-048322-5eqdrd52	195	16	a	a	DT
cord-048322-5eqdrd52	195	17	gene	gene	NN
cord-048322-5eqdrd52	195	18	required	require	VBN
cord-048322-5eqdrd52	195	19	for	for	IN
cord-048322-5eqdrd52	195	20	establishing	establish	VBG
cord-048322-5eqdrd52	195	21	polarity	polarity	NN
cord-048322-5eqdrd52	195	22	in	in	IN
cord-048322-5eqdrd52	195	23	C.	C.	NNP
cord-048322-5eqdrd52	195	24	elegans	elegan	NNS
cord-048322-5eqdrd52	195	25	embryos	embryo	NNS
cord-048322-5eqdrd52	195	26	,	,	,
cord-048322-5eqdrd52	195	27	encodes	encode	VBZ
cord-048322-5eqdrd52	195	28	a	a	DT
cord-048322-5eqdrd52	195	29	putative	putative	JJ
cord-048322-5eqdrd52	195	30	Ser	Ser	NNP
cord-048322-5eqdrd52	195	31	/	/	SYM
cord-048322-5eqdrd52	195	32	Thr	Thr	NNP
cord-048322-5eqdrd52	195	33	kinase	kinase	NN
cord-048322-5eqdrd52	195	34	that	that	WDT
cord-048322-5eqdrd52	195	35	is	be	VBZ
cord-048322-5eqdrd52	195	36	asymmetrically	asymmetrically	RB
cord-048322-5eqdrd52	195	37	distributed	distribute	VBN
cord-048322-5eqdrd52	195	38	A	a	DT
cord-048322-5eqdrd52	195	39	species	specie	NNS
cord-048322-5eqdrd52	195	40	of	of	IN
cord-048322-5eqdrd52	195	41	small	small	JJ
cord-048322-5eqdrd52	195	42	antisense	antisense	NN
cord-048322-5eqdrd52	195	43	RNA	RNA	NNP
cord-048322-5eqdrd52	195	44	in	in	IN
cord-048322-5eqdrd52	195	45	posttranscriptional	posttranscriptional	JJ
cord-048322-5eqdrd52	195	46	gene	gene	NN
cord-048322-5eqdrd52	195	47	silencing	silence	VBG
cord-048322-5eqdrd52	195	48	in	in	IN
cord-048322-5eqdrd52	195	49	plants	plant	NNS
cord-048322-5eqdrd52	196	1	RNAi	RNAi	NNP
cord-048322-5eqdrd52	196	2	:	:	:
cord-048322-5eqdrd52	196	3	doublestranded	doublestranded	NNP
cord-048322-5eqdrd52	196	4	RNA	RNA	NNP
cord-048322-5eqdrd52	196	5	directs	direct	VBZ
cord-048322-5eqdrd52	196	6	the	the	DT
cord-048322-5eqdrd52	196	7	ATP	ATP	NNP
cord-048322-5eqdrd52	196	8	-	-	HYPH
cord-048322-5eqdrd52	196	9	dependent	dependent	JJ
cord-048322-5eqdrd52	196	10	cleavage	cleavage	NN
cord-048322-5eqdrd52	196	11	of	of	IN
cord-048322-5eqdrd52	196	12	mRNA	mrna	NN
cord-048322-5eqdrd52	196	13	at	at	IN
cord-048322-5eqdrd52	197	1	21	21	CD
cord-048322-5eqdrd52	197	2	to	to	TO
cord-048322-5eqdrd52	197	3	23	23	CD
cord-048322-5eqdrd52	197	4	nucleotide	nucleotide	JJ
cord-048322-5eqdrd52	197	5	intervals	interval	NNS
cord-048322-5eqdrd52	197	6	Role	role	VBP
cord-048322-5eqdrd52	197	7	for	for	IN
cord-048322-5eqdrd52	197	8	a	a	DT
cord-048322-5eqdrd52	197	9	bidentate	bidentate	JJ
cord-048322-5eqdrd52	197	10	ribonuclease	ribonuclease	NN
cord-048322-5eqdrd52	197	11	in	in	IN
cord-048322-5eqdrd52	197	12	the	the	DT
cord-048322-5eqdrd52	197	13	initiation	initiation	NN
cord-048322-5eqdrd52	197	14	step	step	NN
cord-048322-5eqdrd52	197	15	of	of	IN
cord-048322-5eqdrd52	197	16	RNA	RNA	NNP
cord-048322-5eqdrd52	197	17	interference	interference	NN
cord-048322-5eqdrd52	197	18	RNA	RNA	NNP
cord-048322-5eqdrd52	197	19	interference	interference	NN
cord-048322-5eqdrd52	197	20	is	be	VBZ
cord-048322-5eqdrd52	197	21	mediated	mediate	VBN
cord-048322-5eqdrd52	197	22	by	by	IN
cord-048322-5eqdrd52	197	23	21-and	21-and	CD
cord-048322-5eqdrd52	197	24	22-nucleotide	22-nucleotide	CD
cord-048322-5eqdrd52	197	25	RNAs	rna	NNS
cord-048322-5eqdrd52	198	1	An	an	DT
cord-048322-5eqdrd52	198	2	RNAdirected	rnadirected	JJ
cord-048322-5eqdrd52	198	3	nuclease	nuclease	NN
cord-048322-5eqdrd52	198	4	mediates	mediate	VBZ
cord-048322-5eqdrd52	198	5	post	post	JJ
cord-048322-5eqdrd52	198	6	-	-	JJ
cord-048322-5eqdrd52	198	7	transcriptional	transcriptional	JJ
cord-048322-5eqdrd52	198	8	gene	gene	NN
cord-048322-5eqdrd52	198	9	silencing	silence	VBG
cord-048322-5eqdrd52	198	10	in	in	IN
cord-048322-5eqdrd52	198	11	Drosophila	Drosophila	NNP
cord-048322-5eqdrd52	198	12	cells	cell	NNS
cord-048322-5eqdrd52	198	13	Structural	structural	JJ
cord-048322-5eqdrd52	198	14	domains	domain	NNS
cord-048322-5eqdrd52	198	15	in	in	IN
cord-048322-5eqdrd52	198	16	RNAi	RNAi	NNS
cord-048322-5eqdrd52	198	17	.	.	.
cord-048322-5eqdrd52	199	1	FEBS	FEBS	NNP
cord-048322-5eqdrd52	199	2	Letters	Letters	NNPS
cord-048322-5eqdrd52	199	3	ATP	ATP	NNP
cord-048322-5eqdrd52	199	4	requirements	requirement	NNS
cord-048322-5eqdrd52	199	5	and	and	CC
cord-048322-5eqdrd52	199	6	small	small	JJ
cord-048322-5eqdrd52	199	7	interfering	interfere	VBG
cord-048322-5eqdrd52	199	8	RNA	RNA	NNP
cord-048322-5eqdrd52	199	9	structure	structure	NN
cord-048322-5eqdrd52	199	10	in	in	IN
cord-048322-5eqdrd52	199	11	the	the	DT
cord-048322-5eqdrd52	199	12	RNA	RNA	NNP
cord-048322-5eqdrd52	199	13	interference	interference	NN
cord-048322-5eqdrd52	199	14	pathway	pathway	NN
cord-048322-5eqdrd52	199	15	Analysis	Analysis	NNP
cord-048322-5eqdrd52	199	16	of	of	IN
cord-048322-5eqdrd52	199	17	gene	gene	NN
cord-048322-5eqdrd52	199	18	function	function	NN
cord-048322-5eqdrd52	199	19	in	in	IN
cord-048322-5eqdrd52	199	20	somatic	somatic	JJ
cord-048322-5eqdrd52	199	21	mammalian	mammalian	JJ
cord-048322-5eqdrd52	199	22	cells	cell	NNS
cord-048322-5eqdrd52	199	23	using	use	VBG
cord-048322-5eqdrd52	199	24	small	small	JJ
cord-048322-5eqdrd52	199	25	interfering	interfere	VBG
cord-048322-5eqdrd52	199	26	RNAs	rna	NNS
cord-048322-5eqdrd52	199	27	Functional	functional	JJ
cord-048322-5eqdrd52	199	28	anatomy	anatomy	NN
cord-048322-5eqdrd52	199	29	of	of	IN
cord-048322-5eqdrd52	199	30	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	199	31	for	for	IN
cord-048322-5eqdrd52	199	32	mediating	mediate	VBG
cord-048322-5eqdrd52	199	33	efficient	efficient	JJ
cord-048322-5eqdrd52	199	34	RNAi	RNAi	NNS
cord-048322-5eqdrd52	199	35	in	in	IN
cord-048322-5eqdrd52	199	36	Drosophila	Drosophila	NNP
cord-048322-5eqdrd52	199	37	melanogaster	melanogaster	NN
cord-048322-5eqdrd52	199	38	embryo	embryo	NN
cord-048322-5eqdrd52	199	39	lysate	lysate	NN
cord-048322-5eqdrd52	199	40	Positional	positional	JJ
cord-048322-5eqdrd52	199	41	effects	effect	NNS
cord-048322-5eqdrd52	199	42	of	of	IN
cord-048322-5eqdrd52	199	43	short	short	JJ
cord-048322-5eqdrd52	199	44	interfering	interfere	VBG
cord-048322-5eqdrd52	199	45	RNAs	rna	NNS
cord-048322-5eqdrd52	199	46	targeting	target	VBG
cord-048322-5eqdrd52	199	47	the	the	DT
cord-048322-5eqdrd52	199	48	human	human	JJ
cord-048322-5eqdrd52	199	49	coagulation	coagulation	NN
cord-048322-5eqdrd52	199	50	trigger	trigger	NN
cord-048322-5eqdrd52	199	51	Tissue	tissue	NN
cord-048322-5eqdrd52	199	52	Factor	Factor	NNP
cord-048322-5eqdrd52	199	53	Synthetic	Synthetic	NNP
cord-048322-5eqdrd52	199	54	dsRNA	dsrna	NN
cord-048322-5eqdrd52	200	1	Dicer	dicer	NN
cord-048322-5eqdrd52	200	2	substrates	substrate	NNS
cord-048322-5eqdrd52	200	3	enhance	enhance	VBP
cord-048322-5eqdrd52	200	4	RNAi	rnai	NN
cord-048322-5eqdrd52	200	5	potency	potency	NN
cord-048322-5eqdrd52	200	6	and	and	CC
cord-048322-5eqdrd52	200	7	efficacy	efficacy	NN
cord-048322-5eqdrd52	201	1	Rational	Rational	NNP
cord-048322-5eqdrd52	201	2	siRNA	siRNA	NNP
cord-048322-5eqdrd52	201	3	design	design	NN
cord-048322-5eqdrd52	201	4	for	for	IN
cord-048322-5eqdrd52	201	5	RNA	RNA	NNP
cord-048322-5eqdrd52	201	6	interference	interference	NN
cord-048322-5eqdrd52	201	7	Site	site	NN
cord-048322-5eqdrd52	201	8	specific	specific	JJ
cord-048322-5eqdrd52	201	9	enzymatic	enzymatic	JJ
cord-048322-5eqdrd52	201	10	cleavage	cleavage	NN
cord-048322-5eqdrd52	201	11	of	of	IN
cord-048322-5eqdrd52	201	12	RNA	RNA	NNP
cord-048322-5eqdrd52	202	1	The	the	DT
cord-048322-5eqdrd52	202	2	efficacy	efficacy	NN
cord-048322-5eqdrd52	202	3	of	of	IN
cord-048322-5eqdrd52	202	4	small	small	JJ
cord-048322-5eqdrd52	202	5	interfering	interfere	VBG
cord-048322-5eqdrd52	202	6	RNAs	rna	NNS
cord-048322-5eqdrd52	202	7	targeted	target	VBN
cord-048322-5eqdrd52	202	8	to	to	IN
cord-048322-5eqdrd52	202	9	the	the	DT
cord-048322-5eqdrd52	202	10	type	type	NN
cord-048322-5eqdrd52	202	11	1	1	CD
cord-048322-5eqdrd52	202	12	insulin	insulin	NN
cord-048322-5eqdrd52	202	13	-	-	HYPH
cord-048322-5eqdrd52	202	14	like	like	JJ
cord-048322-5eqdrd52	202	15	growth	growth	NN
cord-048322-5eqdrd52	202	16	factor	factor	NN
cord-048322-5eqdrd52	202	17	receptor	receptor	NN
cord-048322-5eqdrd52	202	18	(	(	-LRB-
cord-048322-5eqdrd52	202	19	IGF1R	igf1r	NN
cord-048322-5eqdrd52	202	20	)	)	-RRB-
cord-048322-5eqdrd52	202	21	is	be	VBZ
cord-048322-5eqdrd52	202	22	influenced	influence	VBN
cord-048322-5eqdrd52	202	23	by	by	IN
cord-048322-5eqdrd52	202	24	secondary	secondary	JJ
cord-048322-5eqdrd52	202	25	structure	structure	NN
cord-048322-5eqdrd52	202	26	in	in	IN
cord-048322-5eqdrd52	202	27	the	the	DT
cord-048322-5eqdrd52	202	28	IGF1R	IGF1R	NNS
cord-048322-5eqdrd52	202	29	transcript	transcript	NN
cord-048322-5eqdrd52	202	30	Expression	expression	NN
cord-048322-5eqdrd52	202	31	of	of	IN
cord-048322-5eqdrd52	202	32	small	small	JJ
cord-048322-5eqdrd52	202	33	interfering	interfere	VBG
cord-048322-5eqdrd52	202	34	RNAs	rna	NNS
cord-048322-5eqdrd52	202	35	targeted	target	VBN
cord-048322-5eqdrd52	202	36	against	against	IN
cord-048322-5eqdrd52	202	37	HIV-1	HIV-1	NNP
cord-048322-5eqdrd52	202	38	rev	rev	NNP
cord-048322-5eqdrd52	202	39	transcripts	transcript	NNS
cord-048322-5eqdrd52	202	40	in	in	IN
cord-048322-5eqdrd52	202	41	human	human	JJ
cord-048322-5eqdrd52	202	42	cells	cell	NNS
cord-048322-5eqdrd52	203	1	A	a	DT
cord-048322-5eqdrd52	203	2	statistical	statistical	JJ
cord-048322-5eqdrd52	203	3	sampling	sampling	NN
cord-048322-5eqdrd52	203	4	algorithm	algorithm	NN
cord-048322-5eqdrd52	203	5	for	for	IN
cord-048322-5eqdrd52	203	6	RNA	RNA	NNP
cord-048322-5eqdrd52	203	7	secondary	secondary	JJ
cord-048322-5eqdrd52	203	8	structure	structure	NN
cord-048322-5eqdrd52	203	9	prediction	prediction	NN
cord-048322-5eqdrd52	203	10	Efficient	efficient	JJ
cord-048322-5eqdrd52	203	11	reduction	reduction	NN
cord-048322-5eqdrd52	203	12	of	of	IN
cord-048322-5eqdrd52	203	13	target	target	NN
cord-048322-5eqdrd52	203	14	RNAs	rna	NNS
cord-048322-5eqdrd52	203	15	by	by	IN
cord-048322-5eqdrd52	203	16	small	small	JJ
cord-048322-5eqdrd52	203	17	interfering	interfere	VBG
cord-048322-5eqdrd52	203	18	RNA	RNA	NNP
cord-048322-5eqdrd52	203	19	and	and	CC
cord-048322-5eqdrd52	203	20	RNase	RNase	NNP
cord-048322-5eqdrd52	203	21	H	H	NNP
cord-048322-5eqdrd52	203	22	-	-	HYPH
cord-048322-5eqdrd52	203	23	dependent	dependent	JJ
cord-048322-5eqdrd52	203	24	antisense	antisense	NN
cord-048322-5eqdrd52	203	25	agents	agent	NNS
cord-048322-5eqdrd52	203	26	.	.	.
cord-048322-5eqdrd52	204	1	A	a	DT
cord-048322-5eqdrd52	204	2	comparative	comparative	JJ
cord-048322-5eqdrd52	204	3	analysis	analysis	NN
cord-048322-5eqdrd52	205	1	Effective	effective	JJ
cord-048322-5eqdrd52	205	2	small	small	JJ
cord-048322-5eqdrd52	205	3	interfering	interfere	VBG
cord-048322-5eqdrd52	205	4	RNAs	rna	NNS
cord-048322-5eqdrd52	205	5	and	and	CC
cord-048322-5eqdrd52	205	6	phosphorothioate	phosphorothioate	NN
cord-048322-5eqdrd52	205	7	antisense	antisense	NNP
cord-048322-5eqdrd52	205	8	DNAs	dna	NNS
cord-048322-5eqdrd52	205	9	have	have	VBP
cord-048322-5eqdrd52	205	10	different	different	JJ
cord-048322-5eqdrd52	205	11	preferences	preference	NNS
cord-048322-5eqdrd52	205	12	for	for	IN
cord-048322-5eqdrd52	205	13	target	target	NN
cord-048322-5eqdrd52	205	14	sites	site	NNS
cord-048322-5eqdrd52	205	15	in	in	IN
cord-048322-5eqdrd52	205	16	the	the	DT
cord-048322-5eqdrd52	205	17	luciferase	luciferase	NN
cord-048322-5eqdrd52	205	18	mR	mR	NNP
cord-048322-5eqdrd52	205	19	-	-	HYPH
cord-048322-5eqdrd52	205	20	NAs	NAs	NNP
cord-048322-5eqdrd52	206	1	The	the	DT
cord-048322-5eqdrd52	206	2	activity	activity	NN
cord-048322-5eqdrd52	206	3	of	of	IN
cord-048322-5eqdrd52	206	4	siRNA	siRNA	NNP
cord-048322-5eqdrd52	206	5	in	in	IN
cord-048322-5eqdrd52	206	6	mammalian	mammalian	JJ
cord-048322-5eqdrd52	206	7	cells	cell	NNS
cord-048322-5eqdrd52	206	8	is	be	VBZ
cord-048322-5eqdrd52	206	9	related	relate	VBN
cord-048322-5eqdrd52	206	10	to	to	IN
cord-048322-5eqdrd52	206	11	structural	structural	JJ
cord-048322-5eqdrd52	206	12	target	target	NN
cord-048322-5eqdrd52	206	13	accessibility	accessibility	NN
cord-048322-5eqdrd52	206	14	:	:	:
cord-048322-5eqdrd52	206	15	a	a	DT
cord-048322-5eqdrd52	206	16	comparison	comparison	NN
cord-048322-5eqdrd52	206	17	with	with	IN
cord-048322-5eqdrd52	206	18	antisense	antisense	NN
cord-048322-5eqdrd52	206	19	oligonucleotides	oligonucleotide	NNS
cord-048322-5eqdrd52	206	20	Mammalian	mammalian	JJ
cord-048322-5eqdrd52	206	21	RNAi	RNAi	NNS
cord-048322-5eqdrd52	206	22	:	:	:
cord-048322-5eqdrd52	206	23	a	a	DT
cord-048322-5eqdrd52	206	24	practical	practical	JJ
cord-048322-5eqdrd52	206	25	guide	guide	NN
cord-048322-5eqdrd52	206	26	Expression	expression	NN
cord-048322-5eqdrd52	206	27	profiling	profiling	NN
cord-048322-5eqdrd52	206	28	reveals	reveal	VBZ
cord-048322-5eqdrd52	206	29	off	off	IN
cord-048322-5eqdrd52	206	30	-	-	HYPH
cord-048322-5eqdrd52	206	31	target	target	NN
cord-048322-5eqdrd52	206	32	gene	gene	NN
cord-048322-5eqdrd52	206	33	regulation	regulation	NN
cord-048322-5eqdrd52	206	34	by	by	IN
cord-048322-5eqdrd52	206	35	RNAi	RNAi	NNP
cord-048322-5eqdrd52	206	36	Sequence	sequence	NN
cord-048322-5eqdrd52	206	37	-	-	HYPH
cord-048322-5eqdrd52	206	38	specific	specific	JJ
cord-048322-5eqdrd52	206	39	potent	potent	JJ
cord-048322-5eqdrd52	206	40	induction	induction	NN
cord-048322-5eqdrd52	206	41	of	of	IN
cord-048322-5eqdrd52	206	42	IFN	IFN	NNP
cord-048322-5eqdrd52	206	43	-	-	HYPH
cord-048322-5eqdrd52	206	44	alpha	alpha	NN
cord-048322-5eqdrd52	206	45	by	by	IN
cord-048322-5eqdrd52	206	46	short	short	JJ
cord-048322-5eqdrd52	206	47	interfering	interfere	VBG
cord-048322-5eqdrd52	206	48	RNA	RNA	NNP
cord-048322-5eqdrd52	206	49	in	in	IN
cord-048322-5eqdrd52	206	50	plasmacytoid	plasmacytoid	NNP
cord-048322-5eqdrd52	206	51	dendritic	dendritic	JJ
cord-048322-5eqdrd52	206	52	cells	cell	NNS
cord-048322-5eqdrd52	206	53	through	through	IN
cord-048322-5eqdrd52	206	54	TLR7	TLR7	NNP
cord-048322-5eqdrd52	206	55	Activation	Activation	NNP
cord-048322-5eqdrd52	206	56	of	of	IN
cord-048322-5eqdrd52	206	57	the	the	DT
cord-048322-5eqdrd52	206	58	interferon	interferon	NN
cord-048322-5eqdrd52	206	59	system	system	NN
cord-048322-5eqdrd52	206	60	by	by	IN
cord-048322-5eqdrd52	206	61	short	short	RB
cord-048322-5eqdrd52	206	62	-	-	HYPH
cord-048322-5eqdrd52	206	63	interfering	interfere	VBG
cord-048322-5eqdrd52	206	64	RNAs	rna	NNS
cord-048322-5eqdrd52	206	65	Induction	Induction	NNP
cord-048322-5eqdrd52	206	66	of	of	IN
cord-048322-5eqdrd52	206	67	an	an	DT
cord-048322-5eqdrd52	206	68	interferon	interferon	NN
cord-048322-5eqdrd52	206	69	response	response	NN
cord-048322-5eqdrd52	206	70	by	by	IN
cord-048322-5eqdrd52	206	71	RNAi	RNAi	NNP
cord-048322-5eqdrd52	206	72	vectors	vector	NNS
cord-048322-5eqdrd52	206	73	in	in	IN
cord-048322-5eqdrd52	206	74	mammalian	mammalian	JJ
cord-048322-5eqdrd52	206	75	cells	cell	NNS
cord-048322-5eqdrd52	206	76	Duplexes	duplex	NNS
cord-048322-5eqdrd52	206	77	of	of	IN
cord-048322-5eqdrd52	206	78	21-nucleotide	21-nucleotide	CD
cord-048322-5eqdrd52	206	79	RNAs	rna	NNS
cord-048322-5eqdrd52	206	80	mediate	mediate	VBP
cord-048322-5eqdrd52	206	81	RNA	RNA	NNP
cord-048322-5eqdrd52	206	82	interference	interference	NN
cord-048322-5eqdrd52	206	83	in	in	IN
cord-048322-5eqdrd52	206	84	cultured	cultured	JJ
cord-048322-5eqdrd52	206	85	mammalian	mammalian	JJ
cord-048322-5eqdrd52	206	86	cells	cell	NNS
cord-048322-5eqdrd52	207	1	Specific	specific	JJ
cord-048322-5eqdrd52	207	2	inhibition	inhibition	NN
cord-048322-5eqdrd52	207	3	of	of	IN
cord-048322-5eqdrd52	207	4	gene	gene	NN
cord-048322-5eqdrd52	207	5	expression	expression	NN
cord-048322-5eqdrd52	207	6	by	by	IN
cord-048322-5eqdrd52	207	7	small	small	JJ
cord-048322-5eqdrd52	207	8	double	double	RB
cord-048322-5eqdrd52	207	9	-	-	HYPH
cord-048322-5eqdrd52	207	10	stranded	stranded	JJ
cord-048322-5eqdrd52	207	11	RNAs	rna	NNS
cord-048322-5eqdrd52	207	12	in	in	IN
cord-048322-5eqdrd52	207	13	invertebrate	invertebrate	JJ
cord-048322-5eqdrd52	207	14	and	and	CC
cord-048322-5eqdrd52	207	15	vertebrate	vertebrate	JJ
cord-048322-5eqdrd52	207	16	systems	system	NNS
cord-048322-5eqdrd52	207	17	Sequence	sequence	NN
cord-048322-5eqdrd52	207	18	-	-	HYPH
cord-048322-5eqdrd52	207	19	dependent	dependent	JJ
cord-048322-5eqdrd52	207	20	stimulation	stimulation	NN
cord-048322-5eqdrd52	207	21	of	of	IN
cord-048322-5eqdrd52	207	22	the	the	DT
cord-048322-5eqdrd52	207	23	mammalian	mammalian	JJ
cord-048322-5eqdrd52	207	24	innate	innate	JJ
cord-048322-5eqdrd52	207	25	immune	immune	JJ
cord-048322-5eqdrd52	207	26	response	response	NN
cord-048322-5eqdrd52	207	27	by	by	IN
cord-048322-5eqdrd52	207	28	synthetic	synthetic	JJ
cord-048322-5eqdrd52	207	29	siRNA	siRNA	NNP
cord-048322-5eqdrd52	207	30	Interferon	Interferon	NNP
cord-048322-5eqdrd52	207	31	induction	induction	NN
cord-048322-5eqdrd52	207	32	by	by	IN
cord-048322-5eqdrd52	207	33	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	207	34	and	and	CC
cord-048322-5eqdrd52	207	35	ssRNAs	ssRNAs	NNP
cord-048322-5eqdrd52	207	36	synthesized	synthesize	VBN
cord-048322-5eqdrd52	207	37	by	by	IN
cord-048322-5eqdrd52	207	38	phage	phage	NN
cord-048322-5eqdrd52	207	39	polymerase	polymerase	NN
cord-048322-5eqdrd52	207	40	Virus	Virus	NNP
cord-048322-5eqdrd52	207	41	treatment	treatment	NN
cord-048322-5eqdrd52	207	42	questioned	question	VBD
cord-048322-5eqdrd52	207	43	after	after	IN
cord-048322-5eqdrd52	207	44	gene	gene	NN
cord-048322-5eqdrd52	207	45	therapy	therapy	NN
cord-048322-5eqdrd52	207	46	death	death	NN
cord-048322-5eqdrd52	207	47	Molecular	molecular	JJ
cord-048322-5eqdrd52	207	48	basis	basis	NN
cord-048322-5eqdrd52	207	49	of	of	IN
cord-048322-5eqdrd52	207	50	the	the	DT
cord-048322-5eqdrd52	207	51	inflammatory	inflammatory	JJ
cord-048322-5eqdrd52	207	52	response	response	NN
cord-048322-5eqdrd52	207	53	to	to	IN
cord-048322-5eqdrd52	207	54	adenovirus	adenovirus	NN
cord-048322-5eqdrd52	207	55	vectors	vector	NNS
cord-048322-5eqdrd52	207	56	Immune	immune	JJ
cord-048322-5eqdrd52	207	57	responses	response	NNS
cord-048322-5eqdrd52	207	58	to	to	IN
cord-048322-5eqdrd52	207	59	adeno	adeno	NN
cord-048322-5eqdrd52	207	60	-	-	HYPH
cord-048322-5eqdrd52	207	61	associated	associate	VBN
cord-048322-5eqdrd52	207	62	virus	virus	NN
cord-048322-5eqdrd52	207	63	and	and	CC
cord-048322-5eqdrd52	207	64	its	-PRON-	PRP$
cord-048322-5eqdrd52	207	65	recombinant	recombinant	JJ
cord-048322-5eqdrd52	207	66	vectors	vector	NNS
cord-048322-5eqdrd52	207	67	Helper	helper	NN
cord-048322-5eqdrd52	207	68	virus	virus	NN
cord-048322-5eqdrd52	207	69	induced	induce	VBN
cord-048322-5eqdrd52	207	70	T	T	NNP
cord-048322-5eqdrd52	207	71	cell	cell	NN
cord-048322-5eqdrd52	207	72	lymphoma	lymphoma	NN
cord-048322-5eqdrd52	207	73	in	in	IN
cord-048322-5eqdrd52	207	74	nonhuman	nonhuman	NN
cord-048322-5eqdrd52	207	75	primates	primate	NNS
cord-048322-5eqdrd52	207	76	after	after	IN
cord-048322-5eqdrd52	207	77	retroviral	retroviral	JJ
cord-048322-5eqdrd52	207	78	mediated	mediate	VBN
cord-048322-5eqdrd52	207	79	gene	gene	NN
cord-048322-5eqdrd52	207	80	transfer	transfer	NN
cord-048322-5eqdrd52	207	81	Prospects	prospect	NNS
cord-048322-5eqdrd52	207	82	for	for	IN
cord-048322-5eqdrd52	207	83	cationic	cationic	JJ
cord-048322-5eqdrd52	207	84	polymers	polymer	NNS
cord-048322-5eqdrd52	207	85	in	in	IN
cord-048322-5eqdrd52	207	86	gene	gene	NN
cord-048322-5eqdrd52	207	87	and	and	CC
cord-048322-5eqdrd52	207	88	oligonucleotide	oligonucleotide	JJ
cord-048322-5eqdrd52	207	89	therapy	therapy	NN
cord-048322-5eqdrd52	207	90	against	against	IN
cord-048322-5eqdrd52	207	91	cancer	cancer	NN
cord-048322-5eqdrd52	207	92	.	.	.
cord-048322-5eqdrd52	208	1	Advanced	Advanced	NNP
cord-048322-5eqdrd52	208	2	Drug	Drug	NNP
cord-048322-5eqdrd52	208	3	Delivery	Delivery	NNP
cord-048322-5eqdrd52	208	4	Reviews	Reviews	NNP
cord-048322-5eqdrd52	208	5	Cationic	Cationic	NNP
cord-048322-5eqdrd52	208	6	liposomes	liposome	NNS
cord-048322-5eqdrd52	208	7	for	for	IN
cord-048322-5eqdrd52	208	8	gene	gene	NN
cord-048322-5eqdrd52	208	9	delivery	delivery	NN
cord-048322-5eqdrd52	208	10	:	:	:
cord-048322-5eqdrd52	208	11	novel	novel	JJ
cord-048322-5eqdrd52	208	12	cationic	cationic	JJ
cord-048322-5eqdrd52	208	13	lipids	lipid	NNS
cord-048322-5eqdrd52	208	14	and	and	CC
cord-048322-5eqdrd52	208	15	enhancement	enhancement	NN
cord-048322-5eqdrd52	208	16	by	by	IN
cord-048322-5eqdrd52	208	17	proteins	protein	NNS
cord-048322-5eqdrd52	208	18	and	and	CC
cord-048322-5eqdrd52	208	19	peptides	peptide	NNS
cord-048322-5eqdrd52	208	20	Cationic	Cationic	NNP
cord-048322-5eqdrd52	208	21	transfection	transfection	NN
cord-048322-5eqdrd52	208	22	lipids	lipid	VBZ
cord-048322-5eqdrd52	208	23	High	high	JJ
cord-048322-5eqdrd52	208	24	-	-	HYPH
cord-048322-5eqdrd52	208	25	throughput	throughput	NN
cord-048322-5eqdrd52	208	26	screening	screening	NN
cord-048322-5eqdrd52	208	27	of	of	IN
cord-048322-5eqdrd52	208	28	effective	effective	JJ
cord-048322-5eqdrd52	208	29	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	208	30	from	from	IN
cord-048322-5eqdrd52	208	31	RNAi	RNAi	NNP
cord-048322-5eqdrd52	208	32	libraries	library	NNS
cord-048322-5eqdrd52	208	33	delivered	deliver	VBN
cord-048322-5eqdrd52	208	34	via	via	IN
cord-048322-5eqdrd52	208	35	bacterial	bacterial	JJ
cord-048322-5eqdrd52	208	36	invasion	invasion	NN
cord-048322-5eqdrd52	208	37	Size	size	NN
cord-048322-5eqdrd52	208	38	matters	matter	NNS
cord-048322-5eqdrd52	208	39	:	:	:
cord-048322-5eqdrd52	208	40	molecular	molecular	JJ
cord-048322-5eqdrd52	208	41	weight	weight	NN
cord-048322-5eqdrd52	208	42	affects	affect	VBZ
cord-048322-5eqdrd52	208	43	the	the	DT
cord-048322-5eqdrd52	208	44	efficiency	efficiency	NN
cord-048322-5eqdrd52	208	45	of	of	IN
cord-048322-5eqdrd52	208	46	poly(ethylenimine	poly(ethylenimine	NN
cord-048322-5eqdrd52	208	47	)	)	-RRB-
cord-048322-5eqdrd52	208	48	as	as	IN
cord-048322-5eqdrd52	208	49	a	a	DT
cord-048322-5eqdrd52	208	50	gene	gene	NN
cord-048322-5eqdrd52	208	51	delivery	delivery	NN
cord-048322-5eqdrd52	208	52	vehicle	vehicle	NN
cord-048322-5eqdrd52	209	1	The	the	DT
cord-048322-5eqdrd52	209	2	influence	influence	NN
cord-048322-5eqdrd52	209	3	of	of	IN
cord-048322-5eqdrd52	209	4	polymer	polymer	NN
cord-048322-5eqdrd52	209	5	structure	structure	NN
cord-048322-5eqdrd52	209	6	on	on	IN
cord-048322-5eqdrd52	209	7	the	the	DT
cord-048322-5eqdrd52	209	8	interactions	interaction	NNS
cord-048322-5eqdrd52	209	9	of	of	IN
cord-048322-5eqdrd52	209	10	cationic	cationic	JJ
cord-048322-5eqdrd52	209	11	polymers	polymer	NNS
cord-048322-5eqdrd52	209	12	with	with	IN
cord-048322-5eqdrd52	209	13	DNA	dna	NN
cord-048322-5eqdrd52	209	14	and	and	CC
cord-048322-5eqdrd52	209	15	morphology	morphology	NN
cord-048322-5eqdrd52	209	16	of	of	IN
cord-048322-5eqdrd52	209	17	the	the	DT
cord-048322-5eqdrd52	209	18	resulting	result	VBG
cord-048322-5eqdrd52	209	19	complexes	complex	NNS
cord-048322-5eqdrd52	209	20	Preparation	preparation	NN
cord-048322-5eqdrd52	209	21	of	of	IN
cord-048322-5eqdrd52	209	22	a	a	DT
cord-048322-5eqdrd52	209	23	low	low	JJ
cord-048322-5eqdrd52	209	24	molecular	molecular	JJ
cord-048322-5eqdrd52	209	25	weight	weight	NN
cord-048322-5eqdrd52	209	26	polyethylenimine	polyethylenimine	NN
cord-048322-5eqdrd52	209	27	for	for	IN
cord-048322-5eqdrd52	209	28	efficient	efficient	JJ
cord-048322-5eqdrd52	209	29	cell	cell	NN
cord-048322-5eqdrd52	209	30	transfection	transfection	NN
cord-048322-5eqdrd52	210	1	A	a	DT
cord-048322-5eqdrd52	210	2	versatile	versatile	JJ
cord-048322-5eqdrd52	210	3	vector	vector	NN
cord-048322-5eqdrd52	210	4	for	for	IN
cord-048322-5eqdrd52	210	5	gene	gene	NN
cord-048322-5eqdrd52	210	6	and	and	CC
cord-048322-5eqdrd52	210	7	oligonucleotide	oligonucleotide	JJ
cord-048322-5eqdrd52	210	8	transfer	transfer	NN
cord-048322-5eqdrd52	210	9	into	into	IN
cord-048322-5eqdrd52	210	10	cells	cell	NNS
cord-048322-5eqdrd52	210	11	in	in	IN
cord-048322-5eqdrd52	210	12	culture	culture	NN
cord-048322-5eqdrd52	210	13	and	and	CC
cord-048322-5eqdrd52	210	14	in	in	IN
cord-048322-5eqdrd52	210	15	vivo	vivo	NN
cord-048322-5eqdrd52	210	16	:	:	:
cord-048322-5eqdrd52	211	1	polyethylenimine	polyethylenimine	NNP
cord-048322-5eqdrd52	212	1	The	the	DT
cord-048322-5eqdrd52	212	2	proton	proton	NN
cord-048322-5eqdrd52	212	3	sponge	sponge	NN
cord-048322-5eqdrd52	212	4	:	:	:
cord-048322-5eqdrd52	213	1	a	a	DT
cord-048322-5eqdrd52	213	2	trick	trick	NN
cord-048322-5eqdrd52	213	3	to	to	TO
cord-048322-5eqdrd52	213	4	enter	enter	VB
cord-048322-5eqdrd52	213	5	cells	cell	NNS
cord-048322-5eqdrd52	213	6	the	the	DT
cord-048322-5eqdrd52	213	7	viruses	virus	NNS
cord-048322-5eqdrd52	213	8	did	do	VBD
cord-048322-5eqdrd52	213	9	not	not	RB
cord-048322-5eqdrd52	213	10	exploit	exploit	VB
cord-048322-5eqdrd52	213	11	Recent	recent	JJ
cord-048322-5eqdrd52	213	12	advances	advance	NNS
cord-048322-5eqdrd52	213	13	in	in	IN
cord-048322-5eqdrd52	213	14	rational	rational	JJ
cord-048322-5eqdrd52	213	15	gene	gene	NN
cord-048322-5eqdrd52	213	16	transfer	transfer	NN
cord-048322-5eqdrd52	213	17	vector	vector	NN
cord-048322-5eqdrd52	213	18	design	design	NN
cord-048322-5eqdrd52	213	19	based	base	VBN
cord-048322-5eqdrd52	213	20	on	on	IN
cord-048322-5eqdrd52	213	21	poly(ethylene	poly(ethylene	JJ
cord-048322-5eqdrd52	213	22	imine	imine	NN
cord-048322-5eqdrd52	213	23	)	)	-RRB-
cord-048322-5eqdrd52	213	24	and	and	CC
cord-048322-5eqdrd52	213	25	its	-PRON-	PRP$
cord-048322-5eqdrd52	213	26	derivatives	derivative	NNS
cord-048322-5eqdrd52	213	27	Gene	Gene	NNP
cord-048322-5eqdrd52	213	28	transfer	transfer	NN
cord-048322-5eqdrd52	213	29	with	with	IN
cord-048322-5eqdrd52	213	30	modified	modified	JJ
cord-048322-5eqdrd52	213	31	polyethylenimines	polyethylenimine	NNS
cord-048322-5eqdrd52	213	32	Targeted	target	VBD
cord-048322-5eqdrd52	213	33	nucleic	nucleic	JJ
cord-048322-5eqdrd52	213	34	acid	acid	NN
cord-048322-5eqdrd52	213	35	delivery	delivery	NN
cord-048322-5eqdrd52	213	36	into	into	IN
cord-048322-5eqdrd52	213	37	tumors	tumor	NNS
cord-048322-5eqdrd52	213	38	:	:	:
cord-048322-5eqdrd52	213	39	new	new	JJ
cord-048322-5eqdrd52	213	40	avenues	avenue	NNS
cord-048322-5eqdrd52	213	41	for	for	IN
cord-048322-5eqdrd52	213	42	cancer	cancer	NN
cord-048322-5eqdrd52	213	43	therapy	therapy	NN
cord-048322-5eqdrd52	213	44	Transfer	Transfer	NNP
cord-048322-5eqdrd52	213	45	of	of	IN
cord-048322-5eqdrd52	213	46	YACs	yac	NNS
cord-048322-5eqdrd52	213	47	up	up	IN
cord-048322-5eqdrd52	213	48	to	to	IN
cord-048322-5eqdrd52	213	49	2.3	2.3	CD
cord-048322-5eqdrd52	213	50	Mb	Mb	NNS
cord-048322-5eqdrd52	213	51	intact	intact	JJ
cord-048322-5eqdrd52	213	52	into	into	IN
cord-048322-5eqdrd52	213	53	human	human	JJ
cord-048322-5eqdrd52	213	54	cells	cell	NNS
cord-048322-5eqdrd52	213	55	with	with	IN
cord-048322-5eqdrd52	213	56	polyethylenimine	polyethylenimine	NNP
cord-048322-5eqdrd52	213	57	A	a	DT
cord-048322-5eqdrd52	213	58	powerful	powerful	JJ
cord-048322-5eqdrd52	213	59	nonviral	nonviral	JJ
cord-048322-5eqdrd52	213	60	vector	vector	NN
cord-048322-5eqdrd52	213	61	for	for	IN
cord-048322-5eqdrd52	213	62	in	in	IN
cord-048322-5eqdrd52	213	63	vivo	vivo	NN
cord-048322-5eqdrd52	213	64	gene	gene	NN
cord-048322-5eqdrd52	213	65	transfer	transfer	NN
cord-048322-5eqdrd52	213	66	into	into	IN
cord-048322-5eqdrd52	213	67	the	the	DT
cord-048322-5eqdrd52	213	68	adult	adult	NN
cord-048322-5eqdrd52	213	69	mammalian	mammalian	JJ
cord-048322-5eqdrd52	213	70	brain	brain	NN
cord-048322-5eqdrd52	213	71	:	:	:
cord-048322-5eqdrd52	213	72	polyethylenimine	polyethylenimine	NNP
cord-048322-5eqdrd52	213	73	Nonviral	Nonviral	NNP
cord-048322-5eqdrd52	213	74	gene	gene	NN
cord-048322-5eqdrd52	213	75	delivery	delivery	NN
cord-048322-5eqdrd52	213	76	to	to	IN
cord-048322-5eqdrd52	213	77	the	the	DT
cord-048322-5eqdrd52	213	78	rat	rat	NN
cord-048322-5eqdrd52	213	79	kidney	kidney	NN
cord-048322-5eqdrd52	213	80	with	with	IN
cord-048322-5eqdrd52	213	81	polyethylenimine	polyethylenimine	NNP
cord-048322-5eqdrd52	213	82	Polyethylenimine	Polyethylenimine	NNP
cord-048322-5eqdrd52	213	83	-	-	HYPH
cord-048322-5eqdrd52	213	84	based	base	VBN
cord-048322-5eqdrd52	213	85	intravenous	intravenous	JJ
cord-048322-5eqdrd52	213	86	delivery	delivery	NN
cord-048322-5eqdrd52	213	87	of	of	IN
cord-048322-5eqdrd52	213	88	transgenes	transgene	NNS
cord-048322-5eqdrd52	213	89	to	to	IN
cord-048322-5eqdrd52	213	90	mouse	mouse	VB
cord-048322-5eqdrd52	213	91	lung	lung	NN
cord-048322-5eqdrd52	213	92	Polyethylenimine	Polyethylenimine	NNP
cord-048322-5eqdrd52	213	93	-	-	HYPH
cord-048322-5eqdrd52	213	94	mediated	mediate	VBN
cord-048322-5eqdrd52	213	95	cellular	cellular	JJ
cord-048322-5eqdrd52	213	96	uptake	uptake	NN
cord-048322-5eqdrd52	213	97	,	,	,
cord-048322-5eqdrd52	213	98	nucleus	nucleus	NN
cord-048322-5eqdrd52	213	99	trafficking	trafficking	NN
cord-048322-5eqdrd52	213	100	and	and	CC
cord-048322-5eqdrd52	213	101	expression	expression	NN
cord-048322-5eqdrd52	213	102	of	of	IN
cord-048322-5eqdrd52	213	103	cytokine	cytokine	NN
cord-048322-5eqdrd52	213	104	plasmid	plasmid	NN
cord-048322-5eqdrd52	213	105	DNA	DNA	NNP
cord-048322-5eqdrd52	213	106	Polyethylenimine	Polyethylenimine	NNP
cord-048322-5eqdrd52	213	107	shows	show	VBZ
cord-048322-5eqdrd52	213	108	properties	property	NNS
cord-048322-5eqdrd52	213	109	of	of	IN
cord-048322-5eqdrd52	213	110	interest	interest	NN
cord-048322-5eqdrd52	213	111	for	for	IN
cord-048322-5eqdrd52	213	112	cystic	cystic	JJ
cord-048322-5eqdrd52	213	113	fibrosis	fibrosis	NN
cord-048322-5eqdrd52	213	114	gene	gene	NNP
cord-048322-5eqdrd52	213	115	therapy	therapy	NNP
cord-048322-5eqdrd52	213	116	Poly(ethylenimine)-mediated	poly(ethylenimine)-mediated	JJ
cord-048322-5eqdrd52	213	117	transfection	transfection	NN
cord-048322-5eqdrd52	213	118	:	:	:
cord-048322-5eqdrd52	213	119	a	a	DT
cord-048322-5eqdrd52	213	120	new	new	JJ
cord-048322-5eqdrd52	213	121	paradigm	paradigm	NN
cord-048322-5eqdrd52	213	122	for	for	IN
cord-048322-5eqdrd52	213	123	gene	gene	NN
cord-048322-5eqdrd52	213	124	delivery	delivery	NN
cord-048322-5eqdrd52	214	1	A	a	DT
cord-048322-5eqdrd52	214	2	novel	novel	JJ
cord-048322-5eqdrd52	214	3	nonviral	nonviral	JJ
cord-048322-5eqdrd52	214	4	vector	vector	NN
cord-048322-5eqdrd52	214	5	for	for	IN
cord-048322-5eqdrd52	214	6	DNA	dna	NN
cord-048322-5eqdrd52	214	7	delivery	delivery	NN
cord-048322-5eqdrd52	214	8	based	base	VBN
cord-048322-5eqdrd52	214	9	on	on	IN
cord-048322-5eqdrd52	214	10	low	low	JJ
cord-048322-5eqdrd52	214	11	molecular	molecular	JJ
cord-048322-5eqdrd52	214	12	weight	weight	NN
cord-048322-5eqdrd52	214	13	,	,	,
cord-048322-5eqdrd52	214	14	branched	branch	VBN
cord-048322-5eqdrd52	214	15	polyethylenimine	polyethylenimine	NNP
cord-048322-5eqdrd52	214	16	:	:	:
cord-048322-5eqdrd52	214	17	effect	effect	NN
cord-048322-5eqdrd52	214	18	of	of	IN
cord-048322-5eqdrd52	214	19	molecular	molecular	JJ
cord-048322-5eqdrd52	214	20	weight	weight	NN
cord-048322-5eqdrd52	214	21	on	on	IN
cord-048322-5eqdrd52	214	22	transfection	transfection	NN
cord-048322-5eqdrd52	214	23	efficiency	efficiency	NN
cord-048322-5eqdrd52	214	24	and	and	CC
cord-048322-5eqdrd52	214	25	cytotoxicity	cytotoxicity	NN
cord-048322-5eqdrd52	214	26	.	.	.
cord-048322-5eqdrd52	215	1	Pharmaceutical	Pharmaceutical	NNP
cord-048322-5eqdrd52	215	2	Research	Research	NNP
cord-048322-5eqdrd52	215	3	Inhibition	Inhibition	NNP
cord-048322-5eqdrd52	215	4	of	of	IN
cord-048322-5eqdrd52	215	5	monocyte	monocyte	JJ
cord-048322-5eqdrd52	215	6	adhesion	adhesion	NN
cord-048322-5eqdrd52	215	7	on	on	IN
cord-048322-5eqdrd52	215	8	brain	brain	NN
cord-048322-5eqdrd52	215	9	-	-	HYPH
cord-048322-5eqdrd52	215	10	derived	derive	VBN
cord-048322-5eqdrd52	215	11	endothelial	endothelial	JJ
cord-048322-5eqdrd52	215	12	cells	cell	NNS
cord-048322-5eqdrd52	215	13	by	by	IN
cord-048322-5eqdrd52	215	14	NF	NF	NNP
cord-048322-5eqdrd52	215	15	-	-	HYPH
cord-048322-5eqdrd52	215	16	kappaB	kappaB	NNP
cord-048322-5eqdrd52	215	17	decoy	decoy	NN
cord-048322-5eqdrd52	215	18	/	/	SYM
cord-048322-5eqdrd52	215	19	polyethylenimine	polyethylenimine	NNP
cord-048322-5eqdrd52	215	20	complexes	complex	NNS
cord-048322-5eqdrd52	216	1	vitro	vitro	FW
cord-048322-5eqdrd52	216	2	cytotoxicity	cytotoxicity	NN
cord-048322-5eqdrd52	216	3	testing	testing	NN
cord-048322-5eqdrd52	216	4	of	of	IN
cord-048322-5eqdrd52	216	5	polycations	polycation	NNS
cord-048322-5eqdrd52	216	6	:	:	:
cord-048322-5eqdrd52	216	7	influence	influence	NN
cord-048322-5eqdrd52	216	8	of	of	IN
cord-048322-5eqdrd52	216	9	polymer	polymer	NN
cord-048322-5eqdrd52	216	10	structure	structure	NN
cord-048322-5eqdrd52	216	11	on	on	IN
cord-048322-5eqdrd52	216	12	cell	cell	NN
cord-048322-5eqdrd52	216	13	viability	viability	NN
cord-048322-5eqdrd52	216	14	and	and	CC
cord-048322-5eqdrd52	216	15	hemolysis	hemolysis	NN
cord-048322-5eqdrd52	216	16	Low	Low	NNP
cord-048322-5eqdrd52	216	17	-	-	HYPH
cord-048322-5eqdrd52	216	18	molecularweight	molecularweight	NN
cord-048322-5eqdrd52	216	19	polyethylenimine	polyethylenimine	NN
cord-048322-5eqdrd52	216	20	as	as	IN
cord-048322-5eqdrd52	216	21	a	a	DT
cord-048322-5eqdrd52	216	22	non	non	JJ
cord-048322-5eqdrd52	216	23	-	-	JJ
cord-048322-5eqdrd52	216	24	viral	viral	JJ
cord-048322-5eqdrd52	216	25	vector	vector	NN
cord-048322-5eqdrd52	216	26	for	for	IN
cord-048322-5eqdrd52	216	27	DNA	dna	NN
cord-048322-5eqdrd52	216	28	delivery	delivery	NN
cord-048322-5eqdrd52	216	29	:	:	:
cord-048322-5eqdrd52	217	1	comparison	comparison	NN
cord-048322-5eqdrd52	217	2	of	of	IN
cord-048322-5eqdrd52	217	3	physicochemical	physicochemical	JJ
cord-048322-5eqdrd52	217	4	properties	property	NNS
cord-048322-5eqdrd52	217	5	,	,	,
cord-048322-5eqdrd52	217	6	transfection	transfection	NN
cord-048322-5eqdrd52	217	7	efficiency	efficiency	NN
cord-048322-5eqdrd52	217	8	and	and	CC
cord-048322-5eqdrd52	217	9	in	in	IN
cord-048322-5eqdrd52	217	10	vivo	vivo	NN
cord-048322-5eqdrd52	217	11	distribution	distribution	NN
cord-048322-5eqdrd52	217	12	with	with	IN
cord-048322-5eqdrd52	217	13	highmolecular	highmolecular	NNP
cord-048322-5eqdrd52	217	14	-	-	HYPH
cord-048322-5eqdrd52	217	15	weight	weight	NN
cord-048322-5eqdrd52	217	16	polyethylenimine	polyethylenimine	NN
cord-048322-5eqdrd52	218	1	The	the	DT
cord-048322-5eqdrd52	218	2	size	size	NN
cord-048322-5eqdrd52	218	3	of	of	IN
cord-048322-5eqdrd52	218	4	DNA	dna	NN
cord-048322-5eqdrd52	218	5	/	/	SYM
cord-048322-5eqdrd52	218	6	transferrin	transferrin	NN
cord-048322-5eqdrd52	218	7	-	-	HYPH
cord-048322-5eqdrd52	218	8	PEI	PEI	NNP
cord-048322-5eqdrd52	218	9	complexes	complex	NNS
cord-048322-5eqdrd52	218	10	is	be	VBZ
cord-048322-5eqdrd52	218	11	an	an	DT
cord-048322-5eqdrd52	218	12	important	important	JJ
cord-048322-5eqdrd52	218	13	factor	factor	NN
cord-048322-5eqdrd52	218	14	for	for	IN
cord-048322-5eqdrd52	218	15	gene	gene	NN
cord-048322-5eqdrd52	218	16	expression	expression	NN
cord-048322-5eqdrd52	218	17	in	in	IN
cord-048322-5eqdrd52	218	18	cultured	cultured	JJ
cord-048322-5eqdrd52	218	19	cells	cell	NNS
cord-048322-5eqdrd52	219	1	Different	different	JJ
cord-048322-5eqdrd52	219	2	behavior	behavior	NN
cord-048322-5eqdrd52	219	3	of	of	IN
cord-048322-5eqdrd52	219	4	branched	branched	JJ
cord-048322-5eqdrd52	219	5	and	and	CC
cord-048322-5eqdrd52	219	6	linear	linear	JJ
cord-048322-5eqdrd52	219	7	polyethylenimine	polyethylenimine	NN
cord-048322-5eqdrd52	219	8	for	for	IN
cord-048322-5eqdrd52	219	9	gene	gene	NN
cord-048322-5eqdrd52	219	10	delivery	delivery	NN
cord-048322-5eqdrd52	219	11	in	in	IN
cord-048322-5eqdrd52	219	12	vitro	vitro	FW
cord-048322-5eqdrd52	219	13	and	and	CC
cord-048322-5eqdrd52	219	14	in	in	IN
cord-048322-5eqdrd52	219	15	vivo	vivo	NNP
cord-048322-5eqdrd52	219	16	Polyethylenimine	Polyethylenimine	NNP
cord-048322-5eqdrd52	219	17	-	-	HYPH
cord-048322-5eqdrd52	219	18	based	base	VBN
cord-048322-5eqdrd52	219	19	non	non	JJ
cord-048322-5eqdrd52	219	20	-	-	JJ
cord-048322-5eqdrd52	219	21	viral	viral	JJ
cord-048322-5eqdrd52	219	22	gene	gene	NN
cord-048322-5eqdrd52	219	23	delivery	delivery	NN
cord-048322-5eqdrd52	219	24	systems	system	NNS
cord-048322-5eqdrd52	219	25	Delivery	Delivery	NNP
cord-048322-5eqdrd52	219	26	of	of	IN
cord-048322-5eqdrd52	219	27	unmodified	unmodified	JJ
cord-048322-5eqdrd52	219	28	bioactive	bioactive	JJ
cord-048322-5eqdrd52	219	29	ribozymes	ribozyme	NNS
cord-048322-5eqdrd52	219	30	by	by	IN
cord-048322-5eqdrd52	219	31	an	an	DT
cord-048322-5eqdrd52	219	32	RNA	RNA	NNP
cord-048322-5eqdrd52	219	33	stabilizing	stabilize	VBG
cord-048322-5eqdrd52	219	34	polyethylenimine	polyethylenimine	NNP
cord-048322-5eqdrd52	219	35	LMW	LMW	NNP
cord-048322-5eqdrd52	219	36	PEI	PEI	NNP
cord-048322-5eqdrd52	219	37	efficiently	efficiently	RB
cord-048322-5eqdrd52	219	38	down	down	RB
cord-048322-5eqdrd52	219	39	regulates	regulate	VBZ
cord-048322-5eqdrd52	219	40	gene	gene	NN
cord-048322-5eqdrd52	219	41	expression	expression	NN
cord-048322-5eqdrd52	219	42	Physicochemical	Physicochemical	NNP
cord-048322-5eqdrd52	219	43	and	and	CC
cord-048322-5eqdrd52	219	44	biological	biological	JJ
cord-048322-5eqdrd52	219	45	characterization	characterization	NN
cord-048322-5eqdrd52	219	46	of	of	IN
cord-048322-5eqdrd52	219	47	polyethylenimine	polyethylenimine	JJ
cord-048322-5eqdrd52	219	48	-	-	HYPH
cord-048322-5eqdrd52	219	49	graft	graft	NN
cord-048322-5eqdrd52	219	50	-	-	HYPH
cord-048322-5eqdrd52	219	51	poly(ethylene	poly(ethylene	NN
cord-048322-5eqdrd52	219	52	glycol	glycol	NN
cord-048322-5eqdrd52	219	53	)	)	-RRB-
cord-048322-5eqdrd52	219	54	block	block	NN
cord-048322-5eqdrd52	219	55	copolymers	copolymer	NNS
cord-048322-5eqdrd52	219	56	as	as	IN
cord-048322-5eqdrd52	219	57	a	a	DT
cord-048322-5eqdrd52	219	58	delivery	delivery	NN
cord-048322-5eqdrd52	219	59	system	system	NN
cord-048322-5eqdrd52	219	60	for	for	IN
cord-048322-5eqdrd52	219	61	oligonucleotides	oligonucleotide	NNS
cord-048322-5eqdrd52	219	62	and	and	CC
cord-048322-5eqdrd52	219	63	ribozymes	ribozyme	NNS
cord-048322-5eqdrd52	219	64	.	.	.
cord-048322-5eqdrd52	220	1	Bioconjugate	Bioconjugate	NNP
cord-048322-5eqdrd52	220	2	Chemistry	Chemistry	NNP
cord-048322-5eqdrd52	220	3	Efficiency	Efficiency	NNP
cord-048322-5eqdrd52	220	4	of	of	IN
cord-048322-5eqdrd52	220	5	polyethylenimines	polyethylenimine	NNS
cord-048322-5eqdrd52	220	6	and	and	CC
cord-048322-5eqdrd52	220	7	polyethylenimine	polyethylenimine	JJ
cord-048322-5eqdrd52	220	8	-	-	HYPH
cord-048322-5eqdrd52	220	9	graft	graft	NN
cord-048322-5eqdrd52	220	10	-	-	HYPH
cord-048322-5eqdrd52	220	11	poly	poly	JJ
cord-048322-5eqdrd52	220	12	(	(	-LRB-
cord-048322-5eqdrd52	220	13	ethylene	ethylene	NN
cord-048322-5eqdrd52	220	14	glycol	glycol	NN
cord-048322-5eqdrd52	220	15	)	)	-RRB-
cord-048322-5eqdrd52	220	16	block	block	NN
cord-048322-5eqdrd52	220	17	copolymers	copolymer	NNS
cord-048322-5eqdrd52	221	1	to	to	TO
cord-048322-5eqdrd52	221	2	protect	protect	VB
cord-048322-5eqdrd52	221	3	oligonucleotides	oligonucleotide	NNS
cord-048322-5eqdrd52	221	4	against	against	IN
cord-048322-5eqdrd52	221	5	enzymatic	enzymatic	JJ
cord-048322-5eqdrd52	221	6	degradation	degradation	NN
cord-048322-5eqdrd52	221	7	RNAi	RNAi	NNS
cord-048322-5eqdrd52	221	8	-	-	HYPH
cord-048322-5eqdrd52	221	9	mediated	mediate	VBN
cord-048322-5eqdrd52	221	10	gene	gene	NN
cord-048322-5eqdrd52	221	11	-	-	HYPH
cord-048322-5eqdrd52	221	12	targeting	target	VBG
cord-048322-5eqdrd52	221	13	through	through	IN
cord-048322-5eqdrd52	221	14	systemic	systemic	JJ
cord-048322-5eqdrd52	221	15	application	application	NN
cord-048322-5eqdrd52	221	16	of	of	IN
cord-048322-5eqdrd52	221	17	polyethylenimine	polyethylenimine	NNP
cord-048322-5eqdrd52	221	18	(	(	-LRB-
cord-048322-5eqdrd52	221	19	PEI)-complexed	PEI)-complexed	NNP
cord-048322-5eqdrd52	221	20	siRNA	siRNA	NNP
cord-048322-5eqdrd52	221	21	in	in	IN
cord-048322-5eqdrd52	221	22	vivo	vivo	NNP
cord-048322-5eqdrd52	221	23	Lipid	Lipid	NNP
cord-048322-5eqdrd52	221	24	-	-	HYPH
cord-048322-5eqdrd52	221	25	mediated	mediate	VBN
cord-048322-5eqdrd52	221	26	siRNA	siRNA	NNP
cord-048322-5eqdrd52	221	27	delivery	delivery	NN
cord-048322-5eqdrd52	221	28	down	down	RB
cord-048322-5eqdrd52	221	29	-	-	HYPH
cord-048322-5eqdrd52	221	30	regulates	regulate	VBZ
cord-048322-5eqdrd52	221	31	exogenous	exogenous	JJ
cord-048322-5eqdrd52	221	32	gene	gene	NN
cord-048322-5eqdrd52	221	33	expression	expression	NN
cord-048322-5eqdrd52	221	34	in	in	IN
cord-048322-5eqdrd52	221	35	the	the	DT
cord-048322-5eqdrd52	221	36	mouse	mouse	NN
cord-048322-5eqdrd52	221	37	brain	brain	NN
cord-048322-5eqdrd52	221	38	at	at	IN
cord-048322-5eqdrd52	221	39	picomolar	picomolar	NNP
cord-048322-5eqdrd52	221	40	levels	level	NNS
cord-048322-5eqdrd52	221	41	Stabilization	Stabilization	NNP
cord-048322-5eqdrd52	221	42	of	of	IN
cord-048322-5eqdrd52	221	43	oligonucleotide	oligonucleotide	JJ
cord-048322-5eqdrd52	221	44	-	-	HYPH
cord-048322-5eqdrd52	221	45	polyethylenimine	polyethylenimine	NN
cord-048322-5eqdrd52	221	46	complexes	complex	NNS
cord-048322-5eqdrd52	221	47	by	by	IN
cord-048322-5eqdrd52	221	48	freeze	freeze	NN
cord-048322-5eqdrd52	221	49	-	-	HYPH
cord-048322-5eqdrd52	221	50	drying	drying	NN
cord-048322-5eqdrd52	221	51	:	:	:
cord-048322-5eqdrd52	221	52	physicochemical	physicochemical	JJ
cord-048322-5eqdrd52	221	53	and	and	CC
cord-048322-5eqdrd52	221	54	biological	biological	JJ
cord-048322-5eqdrd52	221	55	characterization	characterization	NN
cord-048322-5eqdrd52	222	1	Cancer	cancer	NN
cord-048322-5eqdrd52	222	2	siRNA	siRNA	NNP
cord-048322-5eqdrd52	222	3	therapy	therapy	NN
cord-048322-5eqdrd52	222	4	by	by	IN
cord-048322-5eqdrd52	222	5	tumor	tumor	NN
cord-048322-5eqdrd52	222	6	selective	selective	JJ
cord-048322-5eqdrd52	222	7	delivery	delivery	NN
cord-048322-5eqdrd52	222	8	with	with	IN
cord-048322-5eqdrd52	222	9	ligand	ligand	NN
cord-048322-5eqdrd52	222	10	-	-	HYPH
cord-048322-5eqdrd52	222	11	targeted	target	VBN
cord-048322-5eqdrd52	222	12	sterically	sterically	RB
cord-048322-5eqdrd52	222	13	stabilized	stabilize	VBD
cord-048322-5eqdrd52	222	14	nanoparticle	nanoparticle	NN
cord-048322-5eqdrd52	222	15	Inhibition	inhibition	NN
cord-048322-5eqdrd52	222	16	of	of	IN
cord-048322-5eqdrd52	222	17	influenza	influenza	NN
cord-048322-5eqdrd52	222	18	virus	virus	NN
cord-048322-5eqdrd52	222	19	production	production	NN
cord-048322-5eqdrd52	222	20	in	in	IN
cord-048322-5eqdrd52	222	21	virus	virus	NN
cord-048322-5eqdrd52	222	22	-	-	HYPH
cord-048322-5eqdrd52	222	23	infected	infect	VBN
cord-048322-5eqdrd52	222	24	mice	mouse	NNS
cord-048322-5eqdrd52	222	25	by	by	IN
cord-048322-5eqdrd52	222	26	RNA	RNA	NNP
cord-048322-5eqdrd52	222	27	interference	interference	NN
cord-048322-5eqdrd52	222	28	Studies	Studies	NNPS
cord-048322-5eqdrd52	222	29	of	of	IN
cord-048322-5eqdrd52	222	30	the	the	DT
cord-048322-5eqdrd52	222	31	HER-2	HER-2	NNP
cord-048322-5eqdrd52	222	32	/	/	SYM
cord-048322-5eqdrd52	222	33	neu	neu	NNP
cord-048322-5eqdrd52	222	34	proto	proto	JJ
cord-048322-5eqdrd52	222	35	-	-	HYPH
cord-048322-5eqdrd52	222	36	oncogene	oncogene	NN
cord-048322-5eqdrd52	222	37	in	in	IN
cord-048322-5eqdrd52	222	38	human	human	JJ
cord-048322-5eqdrd52	222	39	breast	breast	NN
cord-048322-5eqdrd52	222	40	and	and	CC
cord-048322-5eqdrd52	222	41	ovarian	ovarian	JJ
cord-048322-5eqdrd52	222	42	cancer	cancer	NN
cord-048322-5eqdrd52	223	1	HER-2	HER-2	NNP
cord-048322-5eqdrd52	223	2	/	/	SYM
cord-048322-5eqdrd52	223	3	neu	neu	NNP
cord-048322-5eqdrd52	223	4	is	be	VBZ
cord-048322-5eqdrd52	223	5	rate	rate	NN
cord-048322-5eqdrd52	223	6	-	-	HYPH
cord-048322-5eqdrd52	223	7	limiting	limit	VBG
cord-048322-5eqdrd52	223	8	for	for	IN
cord-048322-5eqdrd52	223	9	ovarian	ovarian	JJ
cord-048322-5eqdrd52	223	10	cancer	cancer	NN
cord-048322-5eqdrd52	223	11	growth	growth	NN
cord-048322-5eqdrd52	223	12	.	.	.
cord-048322-5eqdrd52	224	1	Conditional	conditional	JJ
cord-048322-5eqdrd52	224	2	depletion	depletion	NN
cord-048322-5eqdrd52	224	3	of	of	IN
cord-048322-5eqdrd52	224	4	HER-2	HER-2	NNP
cord-048322-5eqdrd52	224	5	/	/	SYM
cord-048322-5eqdrd52	224	6	neu	neu	NNP
cord-048322-5eqdrd52	224	7	by	by	IN
cord-048322-5eqdrd52	224	8	ribozyme	ribozyme	NNP
cord-048322-5eqdrd52	224	9	targeting	target	VBG
cord-048322-5eqdrd52	224	10	Ribozyme	Ribozyme	NNPS
cord-048322-5eqdrd52	224	11	targeting	target	VBG
cord-048322-5eqdrd52	224	12	of	of	IN
cord-048322-5eqdrd52	224	13	HER-2	HER-2	NNP
cord-048322-5eqdrd52	224	14	inhibits	inhibit	VBZ
cord-048322-5eqdrd52	224	15	pancreatic	pancreatic	JJ
cord-048322-5eqdrd52	224	16	cancer	cancer	NN
cord-048322-5eqdrd52	224	17	cell	cell	NN
cord-048322-5eqdrd52	224	18	growth	growth	NN
cord-048322-5eqdrd52	224	19	in	in	IN
cord-048322-5eqdrd52	224	20	vivo	vivo	NNP
cord-048322-5eqdrd52	224	21	Adenovirus	Adenovirus	NNP
cord-048322-5eqdrd52	224	22	-	-	HYPH
cord-048322-5eqdrd52	224	23	mediated	mediate	VBN
cord-048322-5eqdrd52	224	24	ribozyme	ribozyme	NN
cord-048322-5eqdrd52	224	25	targeting	target	VBG
cord-048322-5eqdrd52	224	26	of	of	IN
cord-048322-5eqdrd52	224	27	HER-2	HER-2	NNP
cord-048322-5eqdrd52	224	28	/	/	SYM
cord-048322-5eqdrd52	224	29	neu	neu	NNP
cord-048322-5eqdrd52	224	30	inhibits	inhibit	VBZ
cord-048322-5eqdrd52	224	31	in	in	IN
cord-048322-5eqdrd52	224	32	vivo	vivo	NN
cord-048322-5eqdrd52	224	33	growth	growth	NN
cord-048322-5eqdrd52	224	34	of	of	IN
cord-048322-5eqdrd52	224	35	breast	breast	NN
cord-048322-5eqdrd52	224	36	cancer	cancer	NN
cord-048322-5eqdrd52	224	37	cells	cell	NNS
cord-048322-5eqdrd52	225	1	Adenovirusmediated	adenovirusmediated	JJ
cord-048322-5eqdrd52	225	2	transduction	transduction	NN
cord-048322-5eqdrd52	225	3	of	of	IN
cord-048322-5eqdrd52	225	4	ribozymes	ribozyme	NNS
cord-048322-5eqdrd52	225	5	abrogates	abrogate	VBZ
cord-048322-5eqdrd52	225	6	HER-2	HER-2	NNP
cord-048322-5eqdrd52	225	7	/	/	SYM
cord-048322-5eqdrd52	225	8	neu	neu	NNP
cord-048322-5eqdrd52	225	9	and	and	CC
cord-048322-5eqdrd52	225	10	pleiotrophin	pleiotrophin	NNP
cord-048322-5eqdrd52	225	11	expression	expression	NN
cord-048322-5eqdrd52	225	12	and	and	CC
cord-048322-5eqdrd52	225	13	inhibits	inhibit	VBZ
cord-048322-5eqdrd52	225	14	tumor	tumor	NN
cord-048322-5eqdrd52	225	15	cell	cell	NN
cord-048322-5eqdrd52	225	16	proliferation	proliferation	NN
cord-048322-5eqdrd52	225	17	Small	small	JJ
cord-048322-5eqdrd52	225	18	interfering	interfere	VBG
cord-048322-5eqdrd52	225	19	RNA	RNA	NNP
cord-048322-5eqdrd52	225	20	(	(	-LRB-
cord-048322-5eqdrd52	225	21	siRNA	siRNA	NNP
cord-048322-5eqdrd52	225	22	)	)	-RRB-
cord-048322-5eqdrd52	225	23	inhibits	inhibit	VBZ
cord-048322-5eqdrd52	225	24	the	the	DT
cord-048322-5eqdrd52	225	25	expression	expression	NN
cord-048322-5eqdrd52	225	26	of	of	IN
cord-048322-5eqdrd52	225	27	the	the	DT
cord-048322-5eqdrd52	225	28	Her2	Her2	NNP
cord-048322-5eqdrd52	225	29	/	/	SYM
cord-048322-5eqdrd52	225	30	Neu	Neu	NNP
cord-048322-5eqdrd52	225	31	gene	gene	NN
cord-048322-5eqdrd52	225	32	,	,	,
cord-048322-5eqdrd52	225	33	upregulates	upregulate	VBZ
cord-048322-5eqdrd52	225	34	HLA	HLA	NNP
cord-048322-5eqdrd52	225	35	class	class	NN
cord-048322-5eqdrd52	225	36	I	-PRON-	PRP
cord-048322-5eqdrd52	225	37	and	and	CC
cord-048322-5eqdrd52	225	38	induces	induce	VBZ
cord-048322-5eqdrd52	225	39	apoptosis	apoptosis	NN
cord-048322-5eqdrd52	225	40	of	of	IN
cord-048322-5eqdrd52	225	41	Her2	Her2	NNP
cord-048322-5eqdrd52	225	42	/	/	SYM
cord-048322-5eqdrd52	225	43	Neu	Neu	NNP
cord-048322-5eqdrd52	225	44	positive	positive	JJ
cord-048322-5eqdrd52	225	45	tumor	tumor	NN
cord-048322-5eqdrd52	225	46	cell	cell	NN
cord-048322-5eqdrd52	225	47	lines	line	NNS
cord-048322-5eqdrd52	225	48	Inhibition	inhibition	NN
cord-048322-5eqdrd52	225	49	of	of	IN
cord-048322-5eqdrd52	225	50	breast	breast	NN
cord-048322-5eqdrd52	225	51	and	and	CC
cord-048322-5eqdrd52	225	52	ovarian	ovarian	JJ
cord-048322-5eqdrd52	225	53	tumor	tumor	NN
cord-048322-5eqdrd52	225	54	growth	growth	NN
cord-048322-5eqdrd52	225	55	through	through	IN
cord-048322-5eqdrd52	225	56	multiple	multiple	JJ
cord-048322-5eqdrd52	225	57	signaling	signal	VBG
cord-048322-5eqdrd52	225	58	pathways	pathway	NNS
cord-048322-5eqdrd52	225	59	by	by	IN
cord-048322-5eqdrd52	225	60	using	use	VBG
cord-048322-5eqdrd52	225	61	retrovirus	retrovirus	NN
cord-048322-5eqdrd52	225	62	-	-	HYPH
cord-048322-5eqdrd52	225	63	mediated	mediate	VBN
cord-048322-5eqdrd52	225	64	small	small	JJ
cord-048322-5eqdrd52	225	65	interfering	interfere	VBG
cord-048322-5eqdrd52	225	66	RNA	RNA	NNP
cord-048322-5eqdrd52	225	67	against	against	IN
cord-048322-5eqdrd52	225	68	Her-2	Her-2	NNP
cord-048322-5eqdrd52	225	69	/	/	SYM
cord-048322-5eqdrd52	225	70	neu	neu	NNP
cord-048322-5eqdrd52	225	71	gene	gene	NN
cord-048322-5eqdrd52	225	72	expression	expression	NN
cord-048322-5eqdrd52	226	1	A	a	DT
cord-048322-5eqdrd52	226	2	secreted	secrete	VBN
cord-048322-5eqdrd52	226	3	FGF	FGF	NNP
cord-048322-5eqdrd52	226	4	-	-	HYPH
cord-048322-5eqdrd52	226	5	binding	bind	VBG
cord-048322-5eqdrd52	226	6	protein	protein	NN
cord-048322-5eqdrd52	226	7	can	can	MD
cord-048322-5eqdrd52	226	8	serve	serve	VB
cord-048322-5eqdrd52	226	9	as	as	IN
cord-048322-5eqdrd52	226	10	the	the	DT
cord-048322-5eqdrd52	226	11	angiogenic	angiogenic	NN
cord-048322-5eqdrd52	226	12	switch	switch	NN
cord-048322-5eqdrd52	226	13	in	in	IN
cord-048322-5eqdrd52	226	14	human	human	JJ
cord-048322-5eqdrd52	226	15	cancer	cancer	NN
cord-048322-5eqdrd52	226	16	Ribozyme	Ribozyme	NNPS
cord-048322-5eqdrd52	226	17	-	-	HYPH
cord-048322-5eqdrd52	226	18	targeting	targeting	NN
cord-048322-5eqdrd52	226	19	of	of	IN
cord-048322-5eqdrd52	226	20	a	a	DT
cord-048322-5eqdrd52	226	21	secreted	secrete	VBN
cord-048322-5eqdrd52	226	22	FGF	FGF	NNP
cord-048322-5eqdrd52	226	23	-	-	HYPH
cord-048322-5eqdrd52	226	24	binding	bind	VBG
cord-048322-5eqdrd52	226	25	protein	protein	NN
cord-048322-5eqdrd52	226	26	(	(	-LRB-
cord-048322-5eqdrd52	226	27	FGF	FGF	NNP
cord-048322-5eqdrd52	226	28	-	-	HYPH
cord-048322-5eqdrd52	226	29	BP	BP	NNP
cord-048322-5eqdrd52	226	30	)	)	-RRB-
cord-048322-5eqdrd52	226	31	inhibits	inhibit	VBZ
cord-048322-5eqdrd52	226	32	proliferation	proliferation	NN
cord-048322-5eqdrd52	226	33	of	of	IN
cord-048322-5eqdrd52	226	34	prostate	prostate	NN
cord-048322-5eqdrd52	226	35	cancer	cancer	NN
cord-048322-5eqdrd52	226	36	cells	cell	NNS
cord-048322-5eqdrd52	226	37	in	in	IN
cord-048322-5eqdrd52	226	38	vitro	vitro	FW
cord-048322-5eqdrd52	226	39	and	and	CC
cord-048322-5eqdrd52	226	40	in	in	IN
cord-048322-5eqdrd52	226	41	vivo	vivo	NN
cord-048322-5eqdrd52	227	1	The	the	DT
cord-048322-5eqdrd52	227	2	fibroblast	fibroblast	NN
cord-048322-5eqdrd52	227	3	growth	growth	NN
cord-048322-5eqdrd52	227	4	factor	factor	NN
cord-048322-5eqdrd52	227	5	-	-	HYPH
cord-048322-5eqdrd52	227	6	binding	bind	VBG
cord-048322-5eqdrd52	227	7	protein	protein	NN
cord-048322-5eqdrd52	227	8	FGF	FGF	NNP
cord-048322-5eqdrd52	227	9	-	-	HYPH
cord-048322-5eqdrd52	227	10	BP	BP	NNP
cord-048322-5eqdrd52	227	11	.	.	.
cord-048322-5eqdrd52	228	1	to	to	TO
cord-048322-5eqdrd52	228	2	appear	appear	VB
cord-048322-5eqdrd52	228	3	in	in	IN
cord-048322-5eqdrd52	228	4	The	the	DT
cord-048322-5eqdrd52	228	5	International	International	NNP
cord-048322-5eqdrd52	228	6	Pleiotrophin	Pleiotrophin	NNP
cord-048322-5eqdrd52	228	7	stimulates	stimulate	VBZ
cord-048322-5eqdrd52	228	8	fibroblasts	fibroblast	NNS
cord-048322-5eqdrd52	228	9	and	and	CC
cord-048322-5eqdrd52	228	10	endothelial	endothelial	JJ
cord-048322-5eqdrd52	228	11	and	and	CC
cord-048322-5eqdrd52	228	12	epithelial	epithelial	JJ
cord-048322-5eqdrd52	228	13	cells	cell	NNS
cord-048322-5eqdrd52	228	14	and	and	CC
cord-048322-5eqdrd52	228	15	is	be	VBZ
cord-048322-5eqdrd52	228	16	expressed	express	VBN
cord-048322-5eqdrd52	228	17	in	in	IN
cord-048322-5eqdrd52	228	18	human	human	JJ
cord-048322-5eqdrd52	228	19	cancer	cancer	NN
cord-048322-5eqdrd52	228	20	Anti	anti	JJ
cord-048322-5eqdrd52	228	21	-	-	JJ
cord-048322-5eqdrd52	228	22	apoptotic	apoptotic	JJ
cord-048322-5eqdrd52	228	23	signaling	signaling	NN
cord-048322-5eqdrd52	228	24	of	of	IN
cord-048322-5eqdrd52	228	25	pleiotrophin	pleiotrophin	NNP
cord-048322-5eqdrd52	228	26	through	through	IN
cord-048322-5eqdrd52	228	27	its	-PRON-	PRP$
cord-048322-5eqdrd52	228	28	receptor	receptor	NN
cord-048322-5eqdrd52	228	29	,	,	,
cord-048322-5eqdrd52	228	30	anaplastic	anaplastic	JJ
cord-048322-5eqdrd52	228	31	lymphoma	lymphoma	NN
cord-048322-5eqdrd52	228	32	kinase	kinase	VBZ
cord-048322-5eqdrd52	228	33	A	a	DT
cord-048322-5eqdrd52	228	34	heparin	heparin	NN
cord-048322-5eqdrd52	228	35	-	-	HYPH
cord-048322-5eqdrd52	228	36	binding	bind	VBG
cord-048322-5eqdrd52	228	37	growth	growth	NN
cord-048322-5eqdrd52	228	38	factor	factor	NN
cord-048322-5eqdrd52	228	39	secreted	secrete	VBN
cord-048322-5eqdrd52	228	40	from	from	IN
cord-048322-5eqdrd52	228	41	breast	breast	NN
cord-048322-5eqdrd52	228	42	cancer	cancer	NN
cord-048322-5eqdrd52	228	43	cells	cell	NNS
cord-048322-5eqdrd52	228	44	homologous	homologous	JJ
cord-048322-5eqdrd52	228	45	to	to	IN
cord-048322-5eqdrd52	228	46	a	a	DT
cord-048322-5eqdrd52	228	47	developmentally	developmentally	RB
cord-048322-5eqdrd52	228	48	regulated	regulated	JJ
cord-048322-5eqdrd52	228	49	cytokine	cytokine	NN
cord-048322-5eqdrd52	228	50	A	a	DT
cord-048322-5eqdrd52	228	51	novel	novel	JJ
cord-048322-5eqdrd52	228	52	17	17	CD
cord-048322-5eqdrd52	228	53	kD	kD	VBN
cord-048322-5eqdrd52	228	54	heparin	heparin	NN
cord-048322-5eqdrd52	228	55	-	-	HYPH
cord-048322-5eqdrd52	228	56	binding	bind	VBG
cord-048322-5eqdrd52	228	57	growth	growth	NN
cord-048322-5eqdrd52	228	58	factor	factor	NN
cord-048322-5eqdrd52	228	59	(	(	-LRB-
cord-048322-5eqdrd52	228	60	HBGF-8	HBGF-8	NNP
cord-048322-5eqdrd52	228	61	)	)	-RRB-
cord-048322-5eqdrd52	228	62	in	in	IN
cord-048322-5eqdrd52	228	63	bovine	bovine	JJ
cord-048322-5eqdrd52	228	64	uterus	uterus	NN
cord-048322-5eqdrd52	228	65	:	:	:
cord-048322-5eqdrd52	228	66	purification	purification	NN
cord-048322-5eqdrd52	228	67	and	and	CC
cord-048322-5eqdrd52	228	68	N	n	CD
cord-048322-5eqdrd52	228	69	-	-	HYPH
cord-048322-5eqdrd52	228	70	terminal	terminal	NN
cord-048322-5eqdrd52	228	71	amino	amino	NN
cord-048322-5eqdrd52	228	72	acid	acid	NN
cord-048322-5eqdrd52	228	73	sequence	sequence	NN
cord-048322-5eqdrd52	228	74	Human	human	JJ
cord-048322-5eqdrd52	228	75	breast	breast	NN
cord-048322-5eqdrd52	228	76	cancer	cancer	NN
cord-048322-5eqdrd52	228	77	growth	growth	NN
cord-048322-5eqdrd52	228	78	inhibited	inhibit	VBN
cord-048322-5eqdrd52	228	79	in	in	IN
cord-048322-5eqdrd52	228	80	vivo	vivo	NN
cord-048322-5eqdrd52	228	81	by	by	IN
cord-048322-5eqdrd52	228	82	a	a	DT
cord-048322-5eqdrd52	228	83	dominant	dominant	JJ
cord-048322-5eqdrd52	228	84	negative	negative	JJ
cord-048322-5eqdrd52	228	85	pleiotrophin	pleiotrophin	NN
cord-048322-5eqdrd52	228	86	mutant	mutant	JJ
cord-048322-5eqdrd52	228	87	Melanoma	Melanoma	NNP
cord-048322-5eqdrd52	228	88	angiogenesis	angiogenesis	NN
cord-048322-5eqdrd52	228	89	and	and	CC
cord-048322-5eqdrd52	228	90	metastasis	metastasis	NN
cord-048322-5eqdrd52	228	91	modulated	modulate	VBN
cord-048322-5eqdrd52	228	92	by	by	IN
cord-048322-5eqdrd52	228	93	ribozyme	ribozyme	NNS
cord-048322-5eqdrd52	228	94	targeting	target	VBG
cord-048322-5eqdrd52	228	95	of	of	IN
cord-048322-5eqdrd52	228	96	the	the	DT
cord-048322-5eqdrd52	228	97	secreted	secrete	VBN
cord-048322-5eqdrd52	228	98	growth	growth	NN
cord-048322-5eqdrd52	228	99	factor	factor	NN
cord-048322-5eqdrd52	228	100	pleiotrophin	pleiotrophin	NNP
cord-048322-5eqdrd52	228	101	Ribozyme	Ribozyme	NNPS
cord-048322-5eqdrd52	228	102	-	-	HYPH
cord-048322-5eqdrd52	228	103	targeting	targeting	NN
cord-048322-5eqdrd52	228	104	elucidates	elucidate	VBZ
cord-048322-5eqdrd52	228	105	a	a	DT
cord-048322-5eqdrd52	228	106	direct	direct	JJ
cord-048322-5eqdrd52	228	107	role	role	NN
cord-048322-5eqdrd52	228	108	of	of	IN
cord-048322-5eqdrd52	228	109	pleiotrophin	pleiotrophin	NNP
cord-048322-5eqdrd52	228	110	in	in	IN
cord-048322-5eqdrd52	228	111	tumor	tumor	NN
cord-048322-5eqdrd52	228	112	growth	growth	NN
cord-048322-5eqdrd52	229	1	Wellstein	Wellstein	NNP
cord-048322-5eqdrd52	229	2	A.	A.	NNP
cord-048322-5eqdrd52	229	3	Human	human	JJ
cord-048322-5eqdrd52	229	4	trophoblast	trophoblast	NN
cord-048322-5eqdrd52	229	5	and	and	CC
cord-048322-5eqdrd52	229	6	choriocarcinoma	choriocarcinoma	NN
cord-048322-5eqdrd52	229	7	expression	expression	NN
cord-048322-5eqdrd52	229	8	of	of	IN
cord-048322-5eqdrd52	229	9	the	the	DT
cord-048322-5eqdrd52	229	10	growth	growth	NN
cord-048322-5eqdrd52	229	11	factor	factor	NN
cord-048322-5eqdrd52	229	12	pleiotrophin	pleiotrophin	NNP
cord-048322-5eqdrd52	229	13	attributable	attributable	JJ
cord-048322-5eqdrd52	229	14	to	to	IN
cord-048322-5eqdrd52	229	15	germline	germline	JJ
cord-048322-5eqdrd52	229	16	insertion	insertion	NN
cord-048322-5eqdrd52	229	17	of	of	IN
cord-048322-5eqdrd52	229	18	an	an	DT
cord-048322-5eqdrd52	229	19	endogenous	endogenous	JJ
cord-048322-5eqdrd52	229	20	retrovirus	retrovirus	NN
cord-048322-5eqdrd52	230	1	An	an	DT
cord-048322-5eqdrd52	230	2	angiogenic	angiogenic	JJ
cord-048322-5eqdrd52	230	3	role	role	NN
cord-048322-5eqdrd52	230	4	for	for	IN
cord-048322-5eqdrd52	230	5	the	the	DT
cord-048322-5eqdrd52	230	6	neurokines	neurokines	NNPS
cord-048322-5eqdrd52	230	7	midkine	midkine	NNP
cord-048322-5eqdrd52	230	8	and	and	CC
cord-048322-5eqdrd52	230	9	pleiotrophin	pleiotrophin	NNP
cord-048322-5eqdrd52	230	10	in	in	IN
cord-048322-5eqdrd52	230	11	tumorigenesis	tumorigenesis	NN
cord-048322-5eqdrd52	230	12	Caspase	Caspase	NNP
cord-048322-5eqdrd52	230	13	8	8	CD
cord-048322-5eqdrd52	230	14	small	small	JJ
cord-048322-5eqdrd52	230	15	interfering	interfere	VBG
cord-048322-5eqdrd52	230	16	RNA	RNA	NNP
cord-048322-5eqdrd52	230	17	prevents	prevent	VBZ
cord-048322-5eqdrd52	230	18	acute	acute	JJ
cord-048322-5eqdrd52	230	19	liver	liver	NN
cord-048322-5eqdrd52	230	20	failure	failure	NN
cord-048322-5eqdrd52	230	21	in	in	IN
cord-048322-5eqdrd52	230	22	mice	mouse	NNS
cord-048322-5eqdrd52	231	1	Small	small	JJ
cord-048322-5eqdrd52	231	2	interfering	interfere	VBG
cord-048322-5eqdrd52	231	3	RNA	RNA	NNP
cord-048322-5eqdrd52	231	4	inhibits	inhibit	VBZ
cord-048322-5eqdrd52	231	5	hepatitis	hepatitis	NN
cord-048322-5eqdrd52	231	6	B	B	NNP
cord-048322-5eqdrd52	231	7	virus	virus	NN
cord-048322-5eqdrd52	231	8	replication	replication	NN
cord-048322-5eqdrd52	231	9	in	in	IN
cord-048322-5eqdrd52	231	10	mice	mouse	NNS
cord-048322-5eqdrd52	232	1	Inhibition	inhibition	NN
cord-048322-5eqdrd52	232	2	of	of	IN
cord-048322-5eqdrd52	232	3	hepatitis	hepatitis	NN
cord-048322-5eqdrd52	232	4	B	B	NNP
cord-048322-5eqdrd52	232	5	virus	virus	NN
cord-048322-5eqdrd52	232	6	replication	replication	NN
cord-048322-5eqdrd52	232	7	in	in	IN
cord-048322-5eqdrd52	232	8	vivo	vivo	NN
cord-048322-5eqdrd52	232	9	by	by	IN
cord-048322-5eqdrd52	232	10	nucleoside	nucleoside	JJ
cord-048322-5eqdrd52	232	11	analogues	analogue	NNS
cord-048322-5eqdrd52	232	12	and	and	CC
cord-048322-5eqdrd52	232	13	siRNA	siRNA	NNP
cord-048322-5eqdrd52	232	14	Efficient	efficient	JJ
cord-048322-5eqdrd52	232	15	delivery	delivery	NN
cord-048322-5eqdrd52	232	16	of	of	IN
cord-048322-5eqdrd52	232	17	siRNA	siRNA	NNP
cord-048322-5eqdrd52	232	18	for	for	IN
cord-048322-5eqdrd52	232	19	inhibition	inhibition	NN
cord-048322-5eqdrd52	232	20	of	of	IN
cord-048322-5eqdrd52	232	21	gene	gene	NN
cord-048322-5eqdrd52	232	22	expression	expression	NN
cord-048322-5eqdrd52	232	23	in	in	IN
cord-048322-5eqdrd52	232	24	postnatal	postnatal	JJ
cord-048322-5eqdrd52	232	25	mice	mouse	NNS
cord-048322-5eqdrd52	232	26	RNA	RNA	NNP
cord-048322-5eqdrd52	232	27	interference	interference	NN
cord-048322-5eqdrd52	232	28	targeting	target	VBG
cord-048322-5eqdrd52	232	29	Fas	Fas	NNP
cord-048322-5eqdrd52	232	30	protects	protect	VBZ
cord-048322-5eqdrd52	232	31	mice	mouse	NNS
cord-048322-5eqdrd52	232	32	from	from	IN
cord-048322-5eqdrd52	232	33	fulminant	fulminant	JJ
cord-048322-5eqdrd52	232	34	hepatitis	hepatitis	NN
cord-048322-5eqdrd52	232	35	Lack	lack	NN
cord-048322-5eqdrd52	232	36	of	of	IN
cord-048322-5eqdrd52	232	37	interferon	interferon	NN
cord-048322-5eqdrd52	232	38	response	response	NN
cord-048322-5eqdrd52	232	39	in	in	IN
cord-048322-5eqdrd52	232	40	animals	animal	NNS
cord-048322-5eqdrd52	232	41	to	to	IN
cord-048322-5eqdrd52	232	42	naked	naked	JJ
cord-048322-5eqdrd52	232	43	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	232	44	Sequencespecific	Sequencespecific	NNP
cord-048322-5eqdrd52	232	45	suppression	suppression	NN
cord-048322-5eqdrd52	232	46	of	of	IN
cord-048322-5eqdrd52	232	47	mdr1a/1b	mdr1a/1b	NN
cord-048322-5eqdrd52	232	48	expression	expression	NN
cord-048322-5eqdrd52	232	49	in	in	IN
cord-048322-5eqdrd52	232	50	mice	mouse	NNS
cord-048322-5eqdrd52	232	51	via	via	IN
cord-048322-5eqdrd52	232	52	RNA	RNA	NNP
cord-048322-5eqdrd52	232	53	interference	interference	NN
cord-048322-5eqdrd52	232	54	Caspase-8	Caspase-8	NNP
cord-048322-5eqdrd52	232	55	and	and	CC
cord-048322-5eqdrd52	232	56	caspase-3	caspase-3	NNP
cord-048322-5eqdrd52	232	57	small	small	JJ
cord-048322-5eqdrd52	233	1	interfering	interfere	VBG
cord-048322-5eqdrd52	233	2	RNA	RNA	NNP
cord-048322-5eqdrd52	233	3	decreases	decrease	VBZ
cord-048322-5eqdrd52	233	4	ischemia	ischemia	NN
cord-048322-5eqdrd52	233	5	/	/	SYM
cord-048322-5eqdrd52	233	6	reperfusion	reperfusion	NN
cord-048322-5eqdrd52	233	7	injury	injury	NN
cord-048322-5eqdrd52	233	8	to	to	IN
cord-048322-5eqdrd52	233	9	the	the	DT
cord-048322-5eqdrd52	233	10	liver	liver	NN
cord-048322-5eqdrd52	233	11	in	in	IN
cord-048322-5eqdrd52	233	12	mice	mice	NN
cord-048322-5eqdrd52	233	13	Gene	Gene	NNP
cord-048322-5eqdrd52	233	14	silencing	silencing	NN
cord-048322-5eqdrd52	233	15	in	in	IN
cord-048322-5eqdrd52	233	16	rat	rat	NN
cord-048322-5eqdrd52	233	17	-	-	HYPH
cord-048322-5eqdrd52	233	18	liver	liver	NN
cord-048322-5eqdrd52	233	19	and	and	CC
cord-048322-5eqdrd52	233	20	limb	limb	NN
cord-048322-5eqdrd52	233	21	grafts	graft	NNS
cord-048322-5eqdrd52	233	22	by	by	IN
cord-048322-5eqdrd52	233	23	rapid	rapid	JJ
cord-048322-5eqdrd52	233	24	injection	injection	NN
cord-048322-5eqdrd52	233	25	of	of	IN
cord-048322-5eqdrd52	233	26	small	small	JJ
cord-048322-5eqdrd52	233	27	interference	interference	NN
cord-048322-5eqdrd52	233	28	RNA	RNA	NNP
cord-048322-5eqdrd52	233	29	Silencing	silencing	NN
cord-048322-5eqdrd52	233	30	of	of	IN
cord-048322-5eqdrd52	233	31	CXCR4	CXCR4	NNS
cord-048322-5eqdrd52	234	1	blocks	block	VBZ
cord-048322-5eqdrd52	234	2	breast	breast	NN
cord-048322-5eqdrd52	234	3	cancer	cancer	NN
cord-048322-5eqdrd52	234	4	metastasis	metastasis	NN
cord-048322-5eqdrd52	234	5	.	.	.
cord-048322-5eqdrd52	235	1	Cancer	Cancer	NNP
cord-048322-5eqdrd52	235	2	Research	Research	NNP
cord-048322-5eqdrd52	236	1	Targeting	target	VBG
cord-048322-5eqdrd52	236	2	2A	2a	CD
cord-048322-5eqdrd52	236	3	protease	protease	NN
cord-048322-5eqdrd52	236	4	by	by	IN
cord-048322-5eqdrd52	236	5	RNA	RNA	NNP
cord-048322-5eqdrd52	236	6	interference	interference	NN
cord-048322-5eqdrd52	236	7	attenuates	attenuate	VBZ
cord-048322-5eqdrd52	236	8	coxsackieviral	coxsackieviral	JJ
cord-048322-5eqdrd52	236	9	cytopathogenicity	cytopathogenicity	NN
cord-048322-5eqdrd52	236	10	and	and	CC
cord-048322-5eqdrd52	236	11	promotes	promote	VBZ
cord-048322-5eqdrd52	236	12	survival	survival	NN
cord-048322-5eqdrd52	236	13	in	in	IN
cord-048322-5eqdrd52	236	14	highly	highly	RB
cord-048322-5eqdrd52	236	15	susceptible	susceptible	JJ
cord-048322-5eqdrd52	236	16	mice	mouse	NNS
cord-048322-5eqdrd52	236	17	Systemic	Systemic	NNP
cord-048322-5eqdrd52	236	18	siRNA	siRNA	NNP
cord-048322-5eqdrd52	236	19	-	-	HYPH
cord-048322-5eqdrd52	236	20	mediated	mediate	VBN
cord-048322-5eqdrd52	236	21	gene	gene	NN
cord-048322-5eqdrd52	236	22	silencing	silencing	NN
cord-048322-5eqdrd52	236	23	:	:	:
cord-048322-5eqdrd52	236	24	a	a	DT
cord-048322-5eqdrd52	236	25	new	new	JJ
cord-048322-5eqdrd52	236	26	Journal	Journal	NNP
cord-048322-5eqdrd52	236	27	of	of	IN
cord-048322-5eqdrd52	236	28	Biomedicine	Biomedicine	NNP
cord-048322-5eqdrd52	236	29	and	and	CC
cord-048322-5eqdrd52	236	30	Biotechnology	Biotechnology	NNP
cord-048322-5eqdrd52	236	31	approach	approach	NN
cord-048322-5eqdrd52	236	32	to	to	IN
cord-048322-5eqdrd52	236	33	targeted	target	VBN
cord-048322-5eqdrd52	236	34	therapy	therapy	NN
cord-048322-5eqdrd52	236	35	of	of	IN
cord-048322-5eqdrd52	236	36	cancer	cancer	NN
cord-048322-5eqdrd52	236	37	EphA2	EphA2	NNP
cord-048322-5eqdrd52	236	38	:	:	:
cord-048322-5eqdrd52	236	39	a	a	DT
cord-048322-5eqdrd52	236	40	determinant	determinant	NN
cord-048322-5eqdrd52	236	41	of	of	IN
cord-048322-5eqdrd52	236	42	malignant	malignant	JJ
cord-048322-5eqdrd52	236	43	cellular	cellular	JJ
cord-048322-5eqdrd52	236	44	behavior	behavior	NN
cord-048322-5eqdrd52	236	45	and	and	CC
cord-048322-5eqdrd52	236	46	a	a	DT
cord-048322-5eqdrd52	236	47	potential	potential	JJ
cord-048322-5eqdrd52	236	48	therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	236	49	target	target	NN
cord-048322-5eqdrd52	236	50	in	in	IN
cord-048322-5eqdrd52	236	51	pancreatic	pancreatic	JJ
cord-048322-5eqdrd52	236	52	adenocarcinoma	adenocarcinoma	NN
cord-048322-5eqdrd52	236	53	RNA	RNA	NNP
cord-048322-5eqdrd52	236	54	interference	interference	NN
cord-048322-5eqdrd52	236	55	targeting	target	VBG
cord-048322-5eqdrd52	236	56	focal	focal	JJ
cord-048322-5eqdrd52	236	57	adhesion	adhesion	NN
cord-048322-5eqdrd52	236	58	kinase	kinase	NN
cord-048322-5eqdrd52	236	59	enhances	enhance	VBZ
cord-048322-5eqdrd52	236	60	pancreatic	pancreatic	JJ
cord-048322-5eqdrd52	236	61	adenocarcinoma	adenocarcinoma	NN
cord-048322-5eqdrd52	236	62	gemcitabine	gemcitabine	NNP
cord-048322-5eqdrd52	236	63	chemosensitivity	chemosensitivity	NNP
cord-048322-5eqdrd52	236	64	Small	Small	NNP
cord-048322-5eqdrd52	236	65	interfering	interfere	VBG
cord-048322-5eqdrd52	236	66	RNA	RNA	NNP
cord-048322-5eqdrd52	236	67	targeting	target	VBG
cord-048322-5eqdrd52	236	68	Fas	Fas	NNP
cord-048322-5eqdrd52	236	69	protects	protect	VBZ
cord-048322-5eqdrd52	236	70	mice	mouse	NNS
cord-048322-5eqdrd52	236	71	against	against	IN
cord-048322-5eqdrd52	236	72	renal	renal	JJ
cord-048322-5eqdrd52	236	73	ischemia	ischemia	NN
cord-048322-5eqdrd52	236	74	-	-	HYPH
cord-048322-5eqdrd52	236	75	reperfusion	reperfusion	NN
cord-048322-5eqdrd52	236	76	injury	injury	NN
cord-048322-5eqdrd52	236	77	Protection	Protection	NNP
cord-048322-5eqdrd52	236	78	against	against	IN
cord-048322-5eqdrd52	236	79	lethal	lethal	JJ
cord-048322-5eqdrd52	236	80	influenza	influenza	NN
cord-048322-5eqdrd52	236	81	virus	virus	NN
cord-048322-5eqdrd52	236	82	challenge	challenge	NN
cord-048322-5eqdrd52	236	83	by	by	IN
cord-048322-5eqdrd52	236	84	RNA	RNA	NNP
cord-048322-5eqdrd52	236	85	interference	interference	NN
cord-048322-5eqdrd52	236	86	in	in	IN
cord-048322-5eqdrd52	236	87	vivo	vivo	NNP
cord-048322-5eqdrd52	236	88	Gene	Gene	NNP
cord-048322-5eqdrd52	236	89	silencing	silencing	NN
cord-048322-5eqdrd52	236	90	in	in	IN
cord-048322-5eqdrd52	236	91	the	the	DT
cord-048322-5eqdrd52	236	92	endocrine	endocrine	JJ
cord-048322-5eqdrd52	236	93	pancreas	pancrea	NNS
cord-048322-5eqdrd52	236	94	mediated	mediate	VBN
cord-048322-5eqdrd52	236	95	by	by	IN
cord-048322-5eqdrd52	236	96	short	short	RB
cord-048322-5eqdrd52	236	97	-	-	HYPH
cord-048322-5eqdrd52	236	98	interfering	interfere	VBG
cord-048322-5eqdrd52	236	99	RNA	RNA	NNP
cord-048322-5eqdrd52	237	1	In	in	IN
cord-048322-5eqdrd52	237	2	vivo	vivo	NN
cord-048322-5eqdrd52	237	3	delivery	delivery	NN
cord-048322-5eqdrd52	237	4	of	of	IN
cord-048322-5eqdrd52	237	5	small	small	JJ
cord-048322-5eqdrd52	237	6	interfering	interfere	VBG
cord-048322-5eqdrd52	237	7	RNA	RNA	NNP
cord-048322-5eqdrd52	237	8	targeting	target	VBG
cord-048322-5eqdrd52	237	9	brain	brain	NN
cord-048322-5eqdrd52	237	10	capillary	capillary	NN
cord-048322-5eqdrd52	237	11	endothelial	endothelial	JJ
cord-048322-5eqdrd52	237	12	cells	cell	NNS
cord-048322-5eqdrd52	237	13	SiRNA	SiRNA	VBZ
cord-048322-5eqdrd52	237	14	-	-	HYPH
cord-048322-5eqdrd52	237	15	mediated	mediate	VBN
cord-048322-5eqdrd52	237	16	inhibition	inhibition	NN
cord-048322-5eqdrd52	237	17	of	of	IN
cord-048322-5eqdrd52	237	18	vascular	vascular	JJ
cord-048322-5eqdrd52	237	19	endothelial	endothelial	JJ
cord-048322-5eqdrd52	237	20	growth	growth	NN
cord-048322-5eqdrd52	237	21	factor	factor	NN
cord-048322-5eqdrd52	237	22	severely	severely	RB
cord-048322-5eqdrd52	237	23	limits	limit	VBZ
cord-048322-5eqdrd52	237	24	tumor	tumor	NN
cord-048322-5eqdrd52	237	25	resistance	resistance	NN
cord-048322-5eqdrd52	237	26	to	to	IN
cord-048322-5eqdrd52	237	27	antiangiogenic	antiangiogenic	NNP
cord-048322-5eqdrd52	237	28	thrombospondin-1	thrombospondin-1	NNP
cord-048322-5eqdrd52	237	29	and	and	CC
cord-048322-5eqdrd52	237	30	slows	slow	VBZ
cord-048322-5eqdrd52	237	31	tumor	tumor	NN
cord-048322-5eqdrd52	237	32	vascularization	vascularization	NN
cord-048322-5eqdrd52	237	33	and	and	CC
cord-048322-5eqdrd52	237	34	growth	growth	NN
cord-048322-5eqdrd52	237	35	Variants	variant	NNS
cord-048322-5eqdrd52	237	36	of	of	IN
cord-048322-5eqdrd52	237	37	bcl-2	bcl-2	NNP
cord-048322-5eqdrd52	237	38	specific	specific	JJ
cord-048322-5eqdrd52	237	39	siRNA	siRNA	NNP
cord-048322-5eqdrd52	237	40	for	for	IN
cord-048322-5eqdrd52	237	41	silencing	silence	VBG
cord-048322-5eqdrd52	237	42	antiapoptotic	antiapoptotic	NNP
cord-048322-5eqdrd52	237	43	bcl-2	bcl-2	NNP
cord-048322-5eqdrd52	237	44	in	in	IN
cord-048322-5eqdrd52	237	45	pancreatic	pancreatic	JJ
cord-048322-5eqdrd52	237	46	cancer	cancer	NN
cord-048322-5eqdrd52	238	1	Down	down	IN
cord-048322-5eqdrd52	238	2	-	-	HYPH
cord-048322-5eqdrd52	238	3	regulation	regulation	NN
cord-048322-5eqdrd52	238	4	of	of	IN
cord-048322-5eqdrd52	238	5	apoptosis	apoptosis	NN
cord-048322-5eqdrd52	238	6	mediators	mediator	NNS
cord-048322-5eqdrd52	238	7	by	by	IN
cord-048322-5eqdrd52	238	8	RNAi	RNAi	NNP
cord-048322-5eqdrd52	238	9	inhibits	inhibit	VBZ
cord-048322-5eqdrd52	238	10	axotomy	axotomy	NN
cord-048322-5eqdrd52	238	11	-	-	HYPH
cord-048322-5eqdrd52	238	12	induced	induce	VBN
cord-048322-5eqdrd52	238	13	retinal	retinal	JJ
cord-048322-5eqdrd52	238	14	ganglion	ganglion	NN
cord-048322-5eqdrd52	238	15	cell	cell	NN
cord-048322-5eqdrd52	238	16	death	death	NN
cord-048322-5eqdrd52	238	17	in	in	IN
cord-048322-5eqdrd52	238	18	vivo	vivo	NN
cord-048322-5eqdrd52	239	1	In	in	IN
cord-048322-5eqdrd52	239	2	vivo	vivo	NN
cord-048322-5eqdrd52	239	3	gene	gene	NN
cord-048322-5eqdrd52	239	4	silencing	silencing	NN
cord-048322-5eqdrd52	239	5	(	(	-LRB-
cord-048322-5eqdrd52	239	6	with	with	IN
cord-048322-5eqdrd52	239	7	siRNA	siRNA	NNP
cord-048322-5eqdrd52	239	8	)	)	-RRB-
cord-048322-5eqdrd52	239	9	of	of	IN
cord-048322-5eqdrd52	239	10	pulmonary	pulmonary	JJ
cord-048322-5eqdrd52	239	11	expression	expression	NN
cord-048322-5eqdrd52	239	12	of	of	IN
cord-048322-5eqdrd52	239	13	MIP-2	MIP-2	NNP
cord-048322-5eqdrd52	239	14	versus	versus	IN
cord-048322-5eqdrd52	239	15	KC	KC	NNP
cord-048322-5eqdrd52	239	16	results	result	VBZ
cord-048322-5eqdrd52	239	17	in	in	IN
cord-048322-5eqdrd52	239	18	divergent	divergent	JJ
cord-048322-5eqdrd52	239	19	effects	effect	NNS
cord-048322-5eqdrd52	239	20	on	on	IN
cord-048322-5eqdrd52	239	21	hemorrhageinduced	hemorrhageinduce	VBN
cord-048322-5eqdrd52	239	22	,	,	,
cord-048322-5eqdrd52	239	23	neutrophil	neutrophil	NN
cord-048322-5eqdrd52	239	24	-	-	HYPH
cord-048322-5eqdrd52	239	25	mediated	mediate	VBN
cord-048322-5eqdrd52	239	26	septic	septic	JJ
cord-048322-5eqdrd52	239	27	acute	acute	JJ
cord-048322-5eqdrd52	239	28	lung	lung	NN
cord-048322-5eqdrd52	239	29	injury	injury	NN
cord-048322-5eqdrd52	239	30	RNA	RNA	NNP
cord-048322-5eqdrd52	239	31	interference	interference	NN
cord-048322-5eqdrd52	239	32	in	in	IN
cord-048322-5eqdrd52	239	33	adult	adult	NN
cord-048322-5eqdrd52	239	34	mice	mouse	NNS
cord-048322-5eqdrd52	240	1	Small	small	JJ
cord-048322-5eqdrd52	240	2	interfering	interfere	VBG
cord-048322-5eqdrd52	240	3	RNA	RNA	NNP
cord-048322-5eqdrd52	240	4	(	(	-LRB-
cord-048322-5eqdrd52	240	5	siRNA	siRNA	NNP
cord-048322-5eqdrd52	240	6	)	)	-RRB-
cord-048322-5eqdrd52	241	1	targeting	target	VBG
cord-048322-5eqdrd52	241	2	VEGF	VEGF	NNP
cord-048322-5eqdrd52	241	3	effectively	effectively	RB
cord-048322-5eqdrd52	241	4	inhibits	inhibit	VBZ
cord-048322-5eqdrd52	241	5	ocular	ocular	JJ
cord-048322-5eqdrd52	241	6	neovascularization	neovascularization	NN
cord-048322-5eqdrd52	241	7	in	in	IN
cord-048322-5eqdrd52	241	8	mouse	mouse	NN
cord-048322-5eqdrd52	241	9	model	model	NN
cord-048322-5eqdrd52	241	10	Effects	effect	NNS
cord-048322-5eqdrd52	241	11	of	of	IN
cord-048322-5eqdrd52	241	12	treatment	treatment	NN
cord-048322-5eqdrd52	241	13	with	with	IN
cord-048322-5eqdrd52	241	14	small	small	JJ
cord-048322-5eqdrd52	241	15	interfering	interfere	VBG
cord-048322-5eqdrd52	241	16	RNA	RNA	NNP
cord-048322-5eqdrd52	241	17	on	on	IN
cord-048322-5eqdrd52	241	18	joint	joint	JJ
cord-048322-5eqdrd52	241	19	inflammation	inflammation	NN
cord-048322-5eqdrd52	241	20	in	in	IN
cord-048322-5eqdrd52	241	21	mice	mouse	NNS
cord-048322-5eqdrd52	241	22	with	with	IN
cord-048322-5eqdrd52	241	23	collagen	collagen	NN
cord-048322-5eqdrd52	241	24	-	-	HYPH
cord-048322-5eqdrd52	241	25	induced	induce	VBN
cord-048322-5eqdrd52	241	26	arthritis	arthritis	NN
cord-048322-5eqdrd52	241	27	Modification	modification	NN
cord-048322-5eqdrd52	241	28	of	of	IN
cord-048322-5eqdrd52	241	29	professional	professional	JJ
cord-048322-5eqdrd52	241	30	antigen	antigen	NN
cord-048322-5eqdrd52	241	31	-	-	HYPH
cord-048322-5eqdrd52	241	32	presenting	present	VBG
cord-048322-5eqdrd52	241	33	cells	cell	NNS
cord-048322-5eqdrd52	241	34	with	with	IN
cord-048322-5eqdrd52	241	35	small	small	JJ
cord-048322-5eqdrd52	241	36	interfering	interfere	VBG
cord-048322-5eqdrd52	241	37	RNA	RNA	NNP
cord-048322-5eqdrd52	241	38	in	in	IN
cord-048322-5eqdrd52	241	39	vivo	vivo	NN
cord-048322-5eqdrd52	241	40	to	to	TO
cord-048322-5eqdrd52	241	41	enhance	enhance	VB
cord-048322-5eqdrd52	241	42	cancer	cancer	NN
cord-048322-5eqdrd52	241	43	vaccine	vaccine	NN
cord-048322-5eqdrd52	241	44	potency	potency	NN
cord-048322-5eqdrd52	241	45	Inhibition	inhibition	NN
cord-048322-5eqdrd52	241	46	of	of	IN
cord-048322-5eqdrd52	241	47	respiratory	respiratory	JJ
cord-048322-5eqdrd52	241	48	viruses	virus	NNS
cord-048322-5eqdrd52	241	49	by	by	IN
cord-048322-5eqdrd52	241	50	nasally	nasally	RB
cord-048322-5eqdrd52	241	51	administered	administer	VBN
cord-048322-5eqdrd52	241	52	siRNA	siRNA	NNP
cord-048322-5eqdrd52	241	53	Small	Small	NNP
cord-048322-5eqdrd52	241	54	interfering	interfere	VBG
cord-048322-5eqdrd52	241	55	RNA	RNA	NNP
cord-048322-5eqdrd52	241	56	targeting	target	VBG
cord-048322-5eqdrd52	241	57	heme	heme	NN
cord-048322-5eqdrd52	241	58	oxygenase-1	oxygenase-1	NNP
cord-048322-5eqdrd52	241	59	enhances	enhance	VBZ
cord-048322-5eqdrd52	242	1	ischemia	ischemia	NN
cord-048322-5eqdrd52	242	2	-	-	HYPH
cord-048322-5eqdrd52	242	3	reperfusioninduced	reperfusioninduce	VBN
cord-048322-5eqdrd52	242	4	lung	lung	NN
cord-048322-5eqdrd52	242	5	apoptosis	apoptosis	NN
cord-048322-5eqdrd52	242	6	Using	use	VBG
cord-048322-5eqdrd52	242	7	siRNA	siRNA	NNP
cord-048322-5eqdrd52	242	8	in	in	IN
cord-048322-5eqdrd52	242	9	prophylactic	prophylactic	JJ
cord-048322-5eqdrd52	242	10	and	and	CC
cord-048322-5eqdrd52	242	11	therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	242	12	regimens	regimen	NNS
cord-048322-5eqdrd52	242	13	against	against	IN
cord-048322-5eqdrd52	242	14	SARS	SARS	NNP
cord-048322-5eqdrd52	242	15	coronavirus	coronavirus	NN
cord-048322-5eqdrd52	242	16	in	in	IN
cord-048322-5eqdrd52	242	17	Rhesus	Rhesus	NNP
cord-048322-5eqdrd52	242	18	macaque	macaque	NN
cord-048322-5eqdrd52	242	19	Successful	successful	JJ
cord-048322-5eqdrd52	242	20	incorporation	incorporation	NN
cord-048322-5eqdrd52	242	21	of	of	IN
cord-048322-5eqdrd52	242	22	short	short	RB
cord-048322-5eqdrd52	242	23	-	-	HYPH
cord-048322-5eqdrd52	242	24	interfering	interfere	VBG
cord-048322-5eqdrd52	242	25	RNA	RNA	NNP
cord-048322-5eqdrd52	242	26	into	into	IN
cord-048322-5eqdrd52	242	27	islet	islet	NN
cord-048322-5eqdrd52	242	28	cells	cell	NNS
cord-048322-5eqdrd52	242	29	by	by	IN
cord-048322-5eqdrd52	242	30	in	in	IN
cord-048322-5eqdrd52	242	31	situ	situ	NN
cord-048322-5eqdrd52	242	32	perfusion	perfusion	NN
cord-048322-5eqdrd52	242	33	Anti	Anti	NNP
cord-048322-5eqdrd52	242	34	-	-	NNP
cord-048322-5eqdrd52	242	35	RhoA	RhoA	NNP
cord-048322-5eqdrd52	243	1	and	and	CC
cord-048322-5eqdrd52	243	2	anti	anti	NNP
cord-048322-5eqdrd52	243	3	-	-	NNP
cord-048322-5eqdrd52	243	4	RhoC	RhoC	NNP
cord-048322-5eqdrd52	243	5	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	243	6	inhibit	inhibit	VB
cord-048322-5eqdrd52	243	7	the	the	DT
cord-048322-5eqdrd52	243	8	proliferation	proliferation	NN
cord-048322-5eqdrd52	243	9	and	and	CC
cord-048322-5eqdrd52	243	10	invasiveness	invasiveness	NN
cord-048322-5eqdrd52	243	11	of	of	IN
cord-048322-5eqdrd52	243	12	MDA	MDA	NNP
cord-048322-5eqdrd52	243	13	-	-	HYPH
cord-048322-5eqdrd52	243	14	MB-231	MB-231	NNP
cord-048322-5eqdrd52	243	15	breast	breast	NN
cord-048322-5eqdrd52	243	16	cancer	cancer	NN
cord-048322-5eqdrd52	243	17	cells	cell	NNS
cord-048322-5eqdrd52	243	18	in	in	IN
cord-048322-5eqdrd52	243	19	vitro	vitro	FW
cord-048322-5eqdrd52	243	20	and	and	CC
cord-048322-5eqdrd52	244	1	in	in	IN
cord-048322-5eqdrd52	244	2	vivo	vivo	NNP
cord-048322-5eqdrd52	244	3	Colony	Colony	NNP
cord-048322-5eqdrd52	244	4	-	-	HYPH
cord-048322-5eqdrd52	244	5	stimulating	stimulate	VBG
cord-048322-5eqdrd52	244	6	factor-1	factor-1	NNP
cord-048322-5eqdrd52	244	7	blockade	blockade	NN
cord-048322-5eqdrd52	244	8	by	by	IN
cord-048322-5eqdrd52	244	9	antisense	antisense	NN
cord-048322-5eqdrd52	244	10	oligonucleotides	oligonucleotide	NNS
cord-048322-5eqdrd52	244	11	and	and	CC
cord-048322-5eqdrd52	244	12	small	small	JJ
cord-048322-5eqdrd52	244	13	interfering	interfere	VBG
cord-048322-5eqdrd52	244	14	RNAs	rna	NNS
cord-048322-5eqdrd52	244	15	suppresses	suppress	VBZ
cord-048322-5eqdrd52	244	16	growth	growth	NN
cord-048322-5eqdrd52	244	17	of	of	IN
cord-048322-5eqdrd52	244	18	human	human	JJ
cord-048322-5eqdrd52	244	19	mammary	mammary	JJ
cord-048322-5eqdrd52	244	20	tumor	tumor	NN
cord-048322-5eqdrd52	244	21	xenografts	xenograft	NNS
cord-048322-5eqdrd52	244	22	in	in	IN
cord-048322-5eqdrd52	244	23	mice	mouse	NNS
cord-048322-5eqdrd52	245	1	siRNA	siRNA	NNP
cord-048322-5eqdrd52	245	2	relieves	relieve	VBZ
cord-048322-5eqdrd52	245	3	chronic	chronic	JJ
cord-048322-5eqdrd52	245	4	neuropathic	neuropathic	JJ
cord-048322-5eqdrd52	245	5	pain	pain	NN
cord-048322-5eqdrd52	245	6	Exploring	explore	VBG
cord-048322-5eqdrd52	245	7	RNA	RNA	NNP
cord-048322-5eqdrd52	245	8	inteference	inteference	NN
cord-048322-5eqdrd52	245	9	as	as	IN
cord-048322-5eqdrd52	245	10	a	a	DT
cord-048322-5eqdrd52	245	11	therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	245	12	strategy	strategy	NN
cord-048322-5eqdrd52	245	13	for	for	IN
cord-048322-5eqdrd52	245	14	renal	renal	JJ
cord-048322-5eqdrd52	245	15	disease	disease	NN
cord-048322-5eqdrd52	245	16	Silencing	silencing	NN
cord-048322-5eqdrd52	245	17	of	of	IN
cord-048322-5eqdrd52	245	18	Fas	Fas	NNP
cord-048322-5eqdrd52	245	19	,	,	,
cord-048322-5eqdrd52	245	20	but	but	CC
cord-048322-5eqdrd52	245	21	not	not	RB
cord-048322-5eqdrd52	245	22	caspase-8	caspase-8	JJ
cord-048322-5eqdrd52	245	23	,	,	,
cord-048322-5eqdrd52	245	24	in	in	IN
cord-048322-5eqdrd52	245	25	lung	lung	NN
cord-048322-5eqdrd52	245	26	epithelial	epithelial	JJ
cord-048322-5eqdrd52	245	27	cells	cell	NNS
cord-048322-5eqdrd52	245	28	ameliorates	ameliorate	VBZ
cord-048322-5eqdrd52	245	29	pulmonary	pulmonary	JJ
cord-048322-5eqdrd52	245	30	apoptosis	apoptosis	NN
cord-048322-5eqdrd52	245	31	,	,	,
cord-048322-5eqdrd52	245	32	inflammation	inflammation	NN
cord-048322-5eqdrd52	245	33	,	,	,
cord-048322-5eqdrd52	245	34	and	and	CC
cord-048322-5eqdrd52	245	35	neutrophil	neutrophil	NN
cord-048322-5eqdrd52	245	36	influx	influx	NN
cord-048322-5eqdrd52	245	37	after	after	IN
cord-048322-5eqdrd52	245	38	hemorrhagic	hemorrhagic	JJ
cord-048322-5eqdrd52	245	39	shock	shock	NN
cord-048322-5eqdrd52	245	40	and	and	CC
cord-048322-5eqdrd52	245	41	sepsis	sepsis	NN
cord-048322-5eqdrd52	245	42	Reducing	reduce	VBG
cord-048322-5eqdrd52	245	43	hypothalamic	hypothalamic	JJ
cord-048322-5eqdrd52	245	44	AGRP	AGRP	NNP
cord-048322-5eqdrd52	245	45	by	by	IN
cord-048322-5eqdrd52	245	46	RNA	RNA	NNP
cord-048322-5eqdrd52	245	47	interference	interference	NN
cord-048322-5eqdrd52	245	48	increases	increase	VBZ
cord-048322-5eqdrd52	245	49	metabolic	metabolic	JJ
cord-048322-5eqdrd52	245	50	rate	rate	NN
cord-048322-5eqdrd52	245	51	and	and	CC
cord-048322-5eqdrd52	245	52	decreases	decrease	VBZ
cord-048322-5eqdrd52	245	53	body	body	NN
cord-048322-5eqdrd52	245	54	weight	weight	NN
cord-048322-5eqdrd52	245	55	without	without	IN
cord-048322-5eqdrd52	245	56	influencing	influence	VBG
cord-048322-5eqdrd52	245	57	food	food	NN
cord-048322-5eqdrd52	245	58	intake	intake	NN
cord-048322-5eqdrd52	245	59	Neurochemical	Neurochemical	NNP
cord-048322-5eqdrd52	245	60	and	and	CC
cord-048322-5eqdrd52	245	61	behavioral	behavioral	JJ
cord-048322-5eqdrd52	245	62	consequences	consequence	NNS
cord-048322-5eqdrd52	245	63	of	of	IN
cord-048322-5eqdrd52	245	64	widespread	widespread	JJ
cord-048322-5eqdrd52	245	65	gene	gene	NN
cord-048322-5eqdrd52	245	66	knockdown	knockdown	NN
cord-048322-5eqdrd52	245	67	in	in	IN
cord-048322-5eqdrd52	245	68	the	the	DT
cord-048322-5eqdrd52	245	69	adult	adult	NN
cord-048322-5eqdrd52	245	70	mouse	mouse	NN
cord-048322-5eqdrd52	245	71	brain	brain	NN
cord-048322-5eqdrd52	245	72	by	by	IN
cord-048322-5eqdrd52	245	73	using	use	VBG
cord-048322-5eqdrd52	245	74	nonviral	nonviral	NNP
cord-048322-5eqdrd52	245	75	RNA	RNA	NNP
cord-048322-5eqdrd52	245	76	interference	interference	NN
cord-048322-5eqdrd52	245	77	siRNA	siRNA	NNP
cord-048322-5eqdrd52	245	78	-	-	HYPH
cord-048322-5eqdrd52	245	79	mediated	mediate	VBN
cord-048322-5eqdrd52	245	80	knockdown	knockdown	NN
cord-048322-5eqdrd52	245	81	of	of	IN
cord-048322-5eqdrd52	245	82	the	the	DT
cord-048322-5eqdrd52	245	83	serotonin	serotonin	NN
cord-048322-5eqdrd52	245	84	transporter	transporter	NN
cord-048322-5eqdrd52	245	85	in	in	IN
cord-048322-5eqdrd52	245	86	the	the	DT
cord-048322-5eqdrd52	245	87	adult	adult	NN
cord-048322-5eqdrd52	245	88	mouse	mouse	NN
cord-048322-5eqdrd52	245	89	brain	brain	NN
cord-048322-5eqdrd52	245	90	siRNA	siRNA	NNP
cord-048322-5eqdrd52	245	91	targeted	target	VBN
cord-048322-5eqdrd52	245	92	against	against	IN
cord-048322-5eqdrd52	245	93	amyloid	amyloid	NN
cord-048322-5eqdrd52	245	94	precursor	precursor	NN
cord-048322-5eqdrd52	245	95	protein	protein	NN
cord-048322-5eqdrd52	245	96	impairs	impair	VBZ
cord-048322-5eqdrd52	245	97	synaptic	synaptic	JJ
cord-048322-5eqdrd52	245	98	activity	activity	NN
cord-048322-5eqdrd52	245	99	in	in	IN
cord-048322-5eqdrd52	245	100	vivo	vivo	NNP
cord-048322-5eqdrd52	245	101	Inhibition	inhibition	NN
cord-048322-5eqdrd52	245	102	of	of	IN
cord-048322-5eqdrd52	245	103	ocular	ocular	JJ
cord-048322-5eqdrd52	245	104	angiogenesis	angiogenesis	NN
cord-048322-5eqdrd52	245	105	by	by	IN
cord-048322-5eqdrd52	245	106	siRNA	siRNA	NNP
cord-048322-5eqdrd52	245	107	targeting	target	VBG
cord-048322-5eqdrd52	245	108	vascular	vascular	JJ
cord-048322-5eqdrd52	245	109	endothelial	endothelial	JJ
cord-048322-5eqdrd52	245	110	growth	growth	NN
cord-048322-5eqdrd52	245	111	factor	factor	NN
cord-048322-5eqdrd52	245	112	pathway	pathway	NN
cord-048322-5eqdrd52	245	113	genes	gene	NNS
cord-048322-5eqdrd52	245	114	:	:	:
cord-048322-5eqdrd52	246	1	Therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	246	2	strategy	strategy	NN
cord-048322-5eqdrd52	246	3	for	for	IN
cord-048322-5eqdrd52	246	4	herpetic	herpetic	JJ
cord-048322-5eqdrd52	246	5	stromal	stromal	JJ
cord-048322-5eqdrd52	246	6	keratitis	keratitis	NNP
cord-048322-5eqdrd52	246	7	RNA	RNA	NNP
cord-048322-5eqdrd52	246	8	interference	interference	NN
cord-048322-5eqdrd52	246	9	targeting	target	VBG
cord-048322-5eqdrd52	246	10	transforming	transform	VBG
cord-048322-5eqdrd52	246	11	growth	growth	NN
cord-048322-5eqdrd52	246	12	factor	factor	NN
cord-048322-5eqdrd52	246	13	-	-	HYPH
cord-048322-5eqdrd52	246	14	beta	beta	NN
cord-048322-5eqdrd52	246	15	type	type	NN
cord-048322-5eqdrd52	246	16	II	II	NNP
cord-048322-5eqdrd52	246	17	receptor	receptor	NN
cord-048322-5eqdrd52	246	18	suppresses	suppress	VBZ
cord-048322-5eqdrd52	246	19	ocular	ocular	JJ
cord-048322-5eqdrd52	246	20	inflammation	inflammation	NN
cord-048322-5eqdrd52	246	21	and	and	CC
cord-048322-5eqdrd52	246	22	fibrosis	fibrosis	NN
cord-048322-5eqdrd52	246	23	.	.	.
cord-048322-5eqdrd52	247	1	Molecular	molecular	JJ
cord-048322-5eqdrd52	247	2	Vision	Vision	NNP
cord-048322-5eqdrd52	247	3	Antitumor	Antitumor	NNP
cord-048322-5eqdrd52	247	4	activity	activity	NN
cord-048322-5eqdrd52	247	5	of	of	IN
cord-048322-5eqdrd52	247	6	small	small	JJ
cord-048322-5eqdrd52	247	7	interfering	interfere	VBG
cord-048322-5eqdrd52	247	8	RNA	RNA	NNP
cord-048322-5eqdrd52	247	9	/	/	SYM
cord-048322-5eqdrd52	247	10	cationic	cationic	JJ
cord-048322-5eqdrd52	247	11	liposome	liposome	NN
cord-048322-5eqdrd52	247	12	complex	complex	NN
cord-048322-5eqdrd52	247	13	in	in	IN
cord-048322-5eqdrd52	247	14	mouse	mouse	NN
cord-048322-5eqdrd52	247	15	models	model	NNS
cord-048322-5eqdrd52	247	16	of	of	IN
cord-048322-5eqdrd52	247	17	cancer	cancer	NN
cord-048322-5eqdrd52	247	18	Small	Small	NNP
cord-048322-5eqdrd52	247	19	interfering	interfere	VBG
cord-048322-5eqdrd52	247	20	RNA	RNA	NNP
cord-048322-5eqdrd52	247	21	-	-	HYPH
cord-048322-5eqdrd52	247	22	mediated	mediate	VBN
cord-048322-5eqdrd52	247	23	functional	functional	JJ
cord-048322-5eqdrd52	247	24	silencing	silencing	NN
cord-048322-5eqdrd52	247	25	of	of	IN
cord-048322-5eqdrd52	247	26	vasopressin	vasopressin	NN
cord-048322-5eqdrd52	247	27	V	V	NNP
cord-048322-5eqdrd52	247	28	2	2	CD
cord-048322-5eqdrd52	247	29	receptors	receptor	NNS
cord-048322-5eqdrd52	247	30	in	in	IN
cord-048322-5eqdrd52	247	31	the	the	DT
cord-048322-5eqdrd52	247	32	mouse	mouse	NN
cord-048322-5eqdrd52	247	33	kidney	kidney	NN
cord-048322-5eqdrd52	247	34	Therapeutic	Therapeutic	NNP
cord-048322-5eqdrd52	247	35	EphA2	EphA2	NNP
cord-048322-5eqdrd52	247	36	gene	gene	NN
cord-048322-5eqdrd52	247	37	targeting	target	VBG
cord-048322-5eqdrd52	247	38	in	in	IN
cord-048322-5eqdrd52	247	39	vivo	vivo	NN
cord-048322-5eqdrd52	247	40	using	use	VBG
cord-048322-5eqdrd52	247	41	neutral	neutral	JJ
cord-048322-5eqdrd52	247	42	liposomal	liposomal	IN
cord-048322-5eqdrd52	247	43	small	small	JJ
cord-048322-5eqdrd52	247	44	interfering	interfere	VBG
cord-048322-5eqdrd52	247	45	RNA	RNA	NNP
cord-048322-5eqdrd52	247	46	delivery	delivery	NN
cord-048322-5eqdrd52	247	47	siRNA	sirna	NN
cord-048322-5eqdrd52	247	48	-	-	HYPH
cord-048322-5eqdrd52	247	49	induced	induce	VBN
cord-048322-5eqdrd52	247	50	caveolin-1	caveolin-1	NNP
cord-048322-5eqdrd52	247	51	knockdown	knockdown	NN
cord-048322-5eqdrd52	247	52	in	in	IN
cord-048322-5eqdrd52	247	53	mice	mice	NN
cord-048322-5eqdrd52	247	54	increases	increase	VBZ
cord-048322-5eqdrd52	247	55	lung	lung	NN
cord-048322-5eqdrd52	247	56	vascular	vascular	JJ
cord-048322-5eqdrd52	247	57	permeability	permeability	NN
cord-048322-5eqdrd52	247	58	via	via	IN
cord-048322-5eqdrd52	247	59	the	the	DT
cord-048322-5eqdrd52	247	60	junctional	junctional	JJ
cord-048322-5eqdrd52	247	61	pathway	pathway	NN
cord-048322-5eqdrd52	247	62	Cationic	Cationic	NNP
cord-048322-5eqdrd52	247	63	liposome	liposome	NN
cord-048322-5eqdrd52	247	64	-	-	HYPH
cord-048322-5eqdrd52	247	65	mediated	mediate	VBN
cord-048322-5eqdrd52	247	66	delivery	delivery	NN
cord-048322-5eqdrd52	247	67	of	of	IN
cord-048322-5eqdrd52	247	68	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	247	69	in	in	IN
cord-048322-5eqdrd52	247	70	adult	adult	NN
cord-048322-5eqdrd52	247	71	mice	mouse	NNS
cord-048322-5eqdrd52	247	72	Efficient	efficient	JJ
cord-048322-5eqdrd52	247	73	delivery	delivery	NN
cord-048322-5eqdrd52	247	74	of	of	IN
cord-048322-5eqdrd52	247	75	small	small	JJ
cord-048322-5eqdrd52	247	76	interfering	interfere	VBG
cord-048322-5eqdrd52	247	77	RNA	RNA	NNP
cord-048322-5eqdrd52	247	78	for	for	IN
cord-048322-5eqdrd52	247	79	inhibition	inhibition	NN
cord-048322-5eqdrd52	247	80	of	of	IN
cord-048322-5eqdrd52	247	81	IL-12p40	IL-12p40	NNP
cord-048322-5eqdrd52	247	82	expression	expression	NN
cord-048322-5eqdrd52	247	83	in	in	IN
cord-048322-5eqdrd52	247	84	vivo	vivo	NNP
cord-048322-5eqdrd52	247	85	Small	small	JJ
cord-048322-5eqdrd52	247	86	interfering	interfere	VBG
cord-048322-5eqdrd52	247	87	RNAs	rna	NNS
cord-048322-5eqdrd52	247	88	directed	direct	VBN
cord-048322-5eqdrd52	247	89	against	against	IN
cord-048322-5eqdrd52	247	90	beta	beta	NN
cord-048322-5eqdrd52	247	91	-	-	HYPH
cord-048322-5eqdrd52	247	92	catenin	catenin	NNS
cord-048322-5eqdrd52	247	93	inhibit	inhibit	VBP
cord-048322-5eqdrd52	247	94	the	the	DT
cord-048322-5eqdrd52	247	95	in	in	IN
cord-048322-5eqdrd52	247	96	vitro	vitro	FW
cord-048322-5eqdrd52	247	97	and	and	CC
cord-048322-5eqdrd52	247	98	in	in	IN
cord-048322-5eqdrd52	247	99	vivo	vivo	NN
cord-048322-5eqdrd52	247	100	growth	growth	NN
cord-048322-5eqdrd52	247	101	of	of	IN
cord-048322-5eqdrd52	247	102	colon	colon	NN
cord-048322-5eqdrd52	247	103	cancer	cancer	NN
cord-048322-5eqdrd52	247	104	cells	cell	NNS
cord-048322-5eqdrd52	247	105	Gene	Gene	NNP
cord-048322-5eqdrd52	247	106	silencing	silencing	NN
cord-048322-5eqdrd52	247	107	by	by	IN
cord-048322-5eqdrd52	247	108	systemic	systemic	JJ
cord-048322-5eqdrd52	247	109	delivery	delivery	NN
cord-048322-5eqdrd52	247	110	of	of	IN
cord-048322-5eqdrd52	247	111	synthetic	synthetic	JJ
cord-048322-5eqdrd52	247	112	siRNAs	sirna	NNS
cord-048322-5eqdrd52	247	113	in	in	IN
cord-048322-5eqdrd52	247	114	adult	adult	NN
cord-048322-5eqdrd52	247	115	mice	mouse	NNS
cord-048322-5eqdrd52	247	116	Intravesical	Intravesical	NNP
cord-048322-5eqdrd52	247	117	administration	administration	NN
cord-048322-5eqdrd52	247	118	of	of	IN
cord-048322-5eqdrd52	247	119	small	small	JJ
cord-048322-5eqdrd52	247	120	interfering	interfere	VBG
cord-048322-5eqdrd52	247	121	RNA	RNA	NNP
cord-048322-5eqdrd52	247	122	targeting	target	VBG
cord-048322-5eqdrd52	247	123	PLK-1	PLK-1	NNP
cord-048322-5eqdrd52	248	1	successfully	successfully	RB
cord-048322-5eqdrd52	248	2	prevents	prevent	VBZ
cord-048322-5eqdrd52	248	3	the	the	DT
cord-048322-5eqdrd52	248	4	growth	growth	NN
cord-048322-5eqdrd52	248	5	of	of	IN
cord-048322-5eqdrd52	248	6	bladder	bladder	NN
cord-048322-5eqdrd52	248	7	cancer	cancer	NN
cord-048322-5eqdrd52	249	1	In	in	IN
cord-048322-5eqdrd52	249	2	vitro	vitro	FW
cord-048322-5eqdrd52	249	3	and	and	CC
cord-048322-5eqdrd52	249	4	in	in	IN
cord-048322-5eqdrd52	249	5	vivo	vivo	NN
cord-048322-5eqdrd52	249	6	suppression	suppression	NN
cord-048322-5eqdrd52	249	7	of	of	IN
cord-048322-5eqdrd52	249	8	GJB2	GJB2	NNP
cord-048322-5eqdrd52	249	9	expression	expression	NN
cord-048322-5eqdrd52	249	10	by	by	IN
cord-048322-5eqdrd52	249	11	RNA	RNA	NNP
cord-048322-5eqdrd52	249	12	interference	interference	NN
cord-048322-5eqdrd52	249	13	Blockage	blockage	NN
cord-048322-5eqdrd52	249	14	of	of	IN
cord-048322-5eqdrd52	249	15	the	the	DT
cord-048322-5eqdrd52	249	16	macrophage	macrophage	NN
cord-048322-5eqdrd52	249	17	migration	migration	NN
cord-048322-5eqdrd52	249	18	inhibitory	inhibitory	JJ
cord-048322-5eqdrd52	249	19	factor	factor	NN
cord-048322-5eqdrd52	249	20	expression	expression	NN
cord-048322-5eqdrd52	249	21	by	by	IN
cord-048322-5eqdrd52	249	22	short	short	JJ
cord-048322-5eqdrd52	249	23	interference	interference	NN
cord-048322-5eqdrd52	249	24	RNA	RNA	NNP
cord-048322-5eqdrd52	249	25	inhibited	inhibit	VBD
cord-048322-5eqdrd52	249	26	the	the	DT
cord-048322-5eqdrd52	249	27	rejection	rejection	NN
cord-048322-5eqdrd52	249	28	of	of	IN
cord-048322-5eqdrd52	249	29	an	an	DT
cord-048322-5eqdrd52	249	30	allogeneic	allogeneic	JJ
cord-048322-5eqdrd52	249	31	tracheal	tracheal	NN
cord-048322-5eqdrd52	249	32	graft	graft	NN
cord-048322-5eqdrd52	250	1	Widespread	widespread	JJ
cord-048322-5eqdrd52	250	2	lipoplex	lipoplex	RB
cord-048322-5eqdrd52	250	3	-	-	HYPH
cord-048322-5eqdrd52	250	4	mediated	mediate	VBN
cord-048322-5eqdrd52	250	5	gene	gene	NN
cord-048322-5eqdrd52	250	6	transfer	transfer	NN
cord-048322-5eqdrd52	250	7	to	to	IN
cord-048322-5eqdrd52	250	8	vascular	vascular	JJ
cord-048322-5eqdrd52	250	9	endothelial	endothelial	JJ
cord-048322-5eqdrd52	250	10	cells	cell	NNS
cord-048322-5eqdrd52	250	11	and	and	CC
cord-048322-5eqdrd52	250	12	hemangioblasts	hemangioblast	NNS
cord-048322-5eqdrd52	250	13	in	in	IN
cord-048322-5eqdrd52	250	14	the	the	DT
cord-048322-5eqdrd52	250	15	vertebrate	vertebrate	JJ
cord-048322-5eqdrd52	250	16	embryo	embryo	NN
cord-048322-5eqdrd52	250	17	Systemic	systemic	JJ
cord-048322-5eqdrd52	250	18	delivery	delivery	NN
cord-048322-5eqdrd52	250	19	of	of	IN
cord-048322-5eqdrd52	250	20	Raf	Raf	NNP
cord-048322-5eqdrd52	250	21	-	-	HYPH
cord-048322-5eqdrd52	250	22	siRNA	siRNA	NNP
cord-048322-5eqdrd52	250	23	using	use	VBG
cord-048322-5eqdrd52	250	24	cationic	cationic	JJ
cord-048322-5eqdrd52	250	25	cardiolipin	cardiolipin	NN
cord-048322-5eqdrd52	250	26	liposomes	liposome	NNS
cord-048322-5eqdrd52	250	27	silences	silence	NNS
cord-048322-5eqdrd52	250	28	Raf-1	Raf-1	NNP
cord-048322-5eqdrd52	250	29	expression	expression	NN
cord-048322-5eqdrd52	250	30	and	and	CC
cord-048322-5eqdrd52	250	31	inhibits	inhibit	VBZ
cord-048322-5eqdrd52	250	32	tumor	tumor	NN
cord-048322-5eqdrd52	250	33	growth	growth	NN
cord-048322-5eqdrd52	250	34	in	in	IN
cord-048322-5eqdrd52	250	35	xenograft	xenograft	NN
cord-048322-5eqdrd52	250	36	model	model	NN
cord-048322-5eqdrd52	250	37	of	of	IN
cord-048322-5eqdrd52	250	38	human	human	JJ
cord-048322-5eqdrd52	250	39	prostate	prostate	NN
cord-048322-5eqdrd52	250	40	cancer	cancer	NN
cord-048322-5eqdrd52	250	41	Novel	Novel	NNP
cord-048322-5eqdrd52	250	42	cationic	cationic	JJ
cord-048322-5eqdrd52	250	43	cardiolipin	cardiolipin	NN
cord-048322-5eqdrd52	250	44	analogue	analogue	NN
cord-048322-5eqdrd52	250	45	-	-	HYPH
cord-048322-5eqdrd52	250	46	based	base	VBN
cord-048322-5eqdrd52	250	47	liposome	liposome	NN
cord-048322-5eqdrd52	250	48	for	for	IN
cord-048322-5eqdrd52	250	49	efficient	efficient	JJ
cord-048322-5eqdrd52	250	50	DNA	dna	NN
cord-048322-5eqdrd52	250	51	and	and	CC
cord-048322-5eqdrd52	250	52	small	small	JJ
cord-048322-5eqdrd52	250	53	interfering	interfere	VBG
cord-048322-5eqdrd52	250	54	RNA	RNA	NNP
cord-048322-5eqdrd52	250	55	delivery	delivery	NN
cord-048322-5eqdrd52	250	56	in	in	IN
cord-048322-5eqdrd52	250	57	vitro	vitro	FW
cord-048322-5eqdrd52	250	58	and	and	CC
cord-048322-5eqdrd52	250	59	in	in	IN
cord-048322-5eqdrd52	250	60	vivo	vivo	NN
cord-048322-5eqdrd52	251	1	An	an	DT
cord-048322-5eqdrd52	251	2	efficient	efficient	JJ
cord-048322-5eqdrd52	251	3	intrathecal	intrathecal	JJ
cord-048322-5eqdrd52	251	4	delivery	delivery	NN
cord-048322-5eqdrd52	251	5	of	of	IN
cord-048322-5eqdrd52	251	6	small	small	JJ
cord-048322-5eqdrd52	251	7	interfering	interfere	VBG
cord-048322-5eqdrd52	251	8	RNA	RNA	NNP
cord-048322-5eqdrd52	251	9	to	to	IN
cord-048322-5eqdrd52	251	10	the	the	DT
cord-048322-5eqdrd52	251	11	spinal	spinal	JJ
cord-048322-5eqdrd52	251	12	cord	cord	NN
cord-048322-5eqdrd52	251	13	and	and	CC
cord-048322-5eqdrd52	251	14	peripheral	peripheral	JJ
cord-048322-5eqdrd52	251	15	neurons	neuron	NNS
cord-048322-5eqdrd52	251	16	Comparison	comparison	NN
cord-048322-5eqdrd52	251	17	of	of	IN
cord-048322-5eqdrd52	251	18	antisense	antisense	NN
cord-048322-5eqdrd52	251	19	oligonucleotides	oligonucleotide	NNS
cord-048322-5eqdrd52	251	20	and	and	CC
cord-048322-5eqdrd52	251	21	siR	siR	NNP
cord-048322-5eqdrd52	251	22	-	-	HYPH
cord-048322-5eqdrd52	251	23	NAs	na	NNS
cord-048322-5eqdrd52	251	24	in	in	IN
cord-048322-5eqdrd52	251	25	cell	cell	NN
cord-048322-5eqdrd52	251	26	culture	culture	NN
cord-048322-5eqdrd52	251	27	and	and	CC
cord-048322-5eqdrd52	251	28	in	in	IN
cord-048322-5eqdrd52	251	29	vivo	vivo	NN
cord-048322-5eqdrd52	252	1	An	an	DT
cord-048322-5eqdrd52	252	2	siRNA	sirna	NN
cord-048322-5eqdrd52	252	3	-	-	HYPH
cord-048322-5eqdrd52	252	4	based	base	VBN
cord-048322-5eqdrd52	252	5	microbicide	microbicide	NN
cord-048322-5eqdrd52	252	6	protects	protect	VBZ
cord-048322-5eqdrd52	252	7	mice	mouse	NNS
cord-048322-5eqdrd52	252	8	from	from	IN
cord-048322-5eqdrd52	252	9	lethal	lethal	JJ
cord-048322-5eqdrd52	252	10	herpes	herpe	NNS
cord-048322-5eqdrd52	252	11	simplex	simplex	NN
cord-048322-5eqdrd52	252	12	virus	virus	NN
cord-048322-5eqdrd52	252	13	2	2	CD
cord-048322-5eqdrd52	252	14	infection	infection	NN
cord-048322-5eqdrd52	252	15	Therapeutic	therapeutic	JJ
cord-048322-5eqdrd52	252	16	silencing	silencing	NN
cord-048322-5eqdrd52	252	17	of	of	IN
cord-048322-5eqdrd52	252	18	an	an	DT
cord-048322-5eqdrd52	252	19	endogenous	endogenous	JJ
cord-048322-5eqdrd52	252	20	gene	gene	NN
cord-048322-5eqdrd52	252	21	by	by	IN
cord-048322-5eqdrd52	252	22	systemic	systemic	JJ
cord-048322-5eqdrd52	252	23	administration	administration	NN
cord-048322-5eqdrd52	252	24	of	of	IN
cord-048322-5eqdrd52	252	25	modified	modify	VBN
cord-048322-5eqdrd52	252	26	siRNAs	siRNAs	NNP
cord-048322-5eqdrd52	252	27	Potent	Potent	NNP
cord-048322-5eqdrd52	252	28	and	and	CC
cord-048322-5eqdrd52	252	29	persistent	persistent	JJ
cord-048322-5eqdrd52	252	30	in	in	IN
cord-048322-5eqdrd52	252	31	vivo	vivo	NNP
cord-048322-5eqdrd52	252	32	anti	anti	JJ
cord-048322-5eqdrd52	252	33	-	-	JJ
cord-048322-5eqdrd52	252	34	HBV	hbv	JJ
cord-048322-5eqdrd52	252	35	activity	activity	NN
cord-048322-5eqdrd52	252	36	of	of	IN
cord-048322-5eqdrd52	252	37	chemically	chemically	RB
cord-048322-5eqdrd52	252	38	modified	modify	VBN
cord-048322-5eqdrd52	252	39	siR	siR	NNP
cord-048322-5eqdrd52	252	40	-	-	HYPH
cord-048322-5eqdrd52	252	41	NAs	NAs	NNP
cord-048322-5eqdrd52	252	42	Inhibition	Inhibition	NNP
cord-048322-5eqdrd52	252	43	of	of	IN
cord-048322-5eqdrd52	252	44	gene	gene	NN
cord-048322-5eqdrd52	252	45	expression	expression	NN
cord-048322-5eqdrd52	252	46	in	in	IN
cord-048322-5eqdrd52	252	47	mice	mice	NN
cord-048322-5eqdrd52	252	48	muscle	muscle	NN
cord-048322-5eqdrd52	252	49	by	by	IN
cord-048322-5eqdrd52	252	50	in	in	IN
cord-048322-5eqdrd52	252	51	vivo	vivo	NNP
cord-048322-5eqdrd52	252	52	electrically	electrically	RB
cord-048322-5eqdrd52	252	53	mediated	mediate	VBN
cord-048322-5eqdrd52	252	54	siRNA	siRNA	NNP
cord-048322-5eqdrd52	252	55	delivery	delivery	NN
cord-048322-5eqdrd52	252	56	Small	Small	NNP
cord-048322-5eqdrd52	252	57	interfering	interfere	VBG
cord-048322-5eqdrd52	252	58	RNA	RNA	NNP
cord-048322-5eqdrd52	252	59	targeting	target	VBG
cord-048322-5eqdrd52	252	60	Raf-1	Raf-1	NNP
cord-048322-5eqdrd52	252	61	inhibits	inhibit	VBZ
cord-048322-5eqdrd52	252	62	tumor	tumor	NN
cord-048322-5eqdrd52	252	63	growth	growth	NN
cord-048322-5eqdrd52	252	64	in	in	IN
cord-048322-5eqdrd52	252	65	vitro	vitro	FW
cord-048322-5eqdrd52	252	66	and	and	CC
cord-048322-5eqdrd52	252	67	in	in	IN
cord-048322-5eqdrd52	252	68	vivo	vivo	NN
cord-048322-5eqdrd52	253	1	A	a	DT
cord-048322-5eqdrd52	253	2	small	small	JJ
cord-048322-5eqdrd52	253	3	interfering	interfere	VBG
cord-048322-5eqdrd52	253	4	RNA	rna	NN
cord-048322-5eqdrd52	253	5	targeting	target	VBG
cord-048322-5eqdrd52	253	6	vascular	vascular	JJ
cord-048322-5eqdrd52	253	7	endothelial	endothelial	JJ
cord-048322-5eqdrd52	253	8	growth	growth	NN
cord-048322-5eqdrd52	253	9	factor	factor	NN
cord-048322-5eqdrd52	253	10	as	as	IN
cord-048322-5eqdrd52	253	11	cancer	cancer	NN
cord-048322-5eqdrd52	253	12	therapeutics	therapeutic	NNS
cord-048322-5eqdrd52	254	1	Atelocollagenmediated	atelocollagenmediated	JJ
cord-048322-5eqdrd52	254	2	synthetic	synthetic	JJ
cord-048322-5eqdrd52	254	3	small	small	JJ
cord-048322-5eqdrd52	254	4	interfering	interfere	VBG
cord-048322-5eqdrd52	254	5	RNA	RNA	NNP
cord-048322-5eqdrd52	254	6	delivery	delivery	NN
cord-048322-5eqdrd52	254	7	for	for	IN
cord-048322-5eqdrd52	254	8	effective	effective	JJ
cord-048322-5eqdrd52	254	9	gene	gene	NN
cord-048322-5eqdrd52	254	10	silencing	silencing	NN
cord-048322-5eqdrd52	254	11	in	in	IN
cord-048322-5eqdrd52	254	12	vitro	vitro	FW
cord-048322-5eqdrd52	254	13	and	and	CC
cord-048322-5eqdrd52	254	14	in	in	IN
cord-048322-5eqdrd52	254	15	vivo	vivo	NNP
cord-048322-5eqdrd52	254	16	Efficient	efficient	JJ
cord-048322-5eqdrd52	254	17	delivery	delivery	NN
cord-048322-5eqdrd52	254	18	of	of	IN
cord-048322-5eqdrd52	254	19	small	small	JJ
cord-048322-5eqdrd52	254	20	interfering	interfere	VBG
cord-048322-5eqdrd52	254	21	RNA	RNA	NNP
cord-048322-5eqdrd52	254	22	to	to	IN
cord-048322-5eqdrd52	254	23	bone	bone	NN
cord-048322-5eqdrd52	254	24	-	-	HYPH
cord-048322-5eqdrd52	254	25	metastatic	metastatic	JJ
cord-048322-5eqdrd52	254	26	tumors	tumor	NNS
cord-048322-5eqdrd52	254	27	by	by	IN
cord-048322-5eqdrd52	254	28	using	use	VBG
cord-048322-5eqdrd52	254	29	atelocollagen	atelocollagen	NNP
cord-048322-5eqdrd52	254	30	in	in	IN
cord-048322-5eqdrd52	254	31	vivo	vivo	NNP
cord-048322-5eqdrd52	254	32	Rad51	Rad51	NNP
cord-048322-5eqdrd52	254	33	siRNA	siRNA	NNP
cord-048322-5eqdrd52	254	34	delivered	deliver	VBN
cord-048322-5eqdrd52	254	35	by	by	IN
cord-048322-5eqdrd52	254	36	HVJ	HVJ	NNP
cord-048322-5eqdrd52	254	37	envelope	envelope	NN
cord-048322-5eqdrd52	254	38	vector	vector	NN
cord-048322-5eqdrd52	254	39	enhances	enhance	VBZ
cord-048322-5eqdrd52	254	40	the	the	DT
cord-048322-5eqdrd52	254	41	anti	anti	JJ
cord-048322-5eqdrd52	254	42	-	-	JJ
cord-048322-5eqdrd52	254	43	cancer	cancer	JJ
cord-048322-5eqdrd52	254	44	effect	effect	NN
cord-048322-5eqdrd52	254	45	of	of	IN
cord-048322-5eqdrd52	254	46	cisplatin	cisplatin	NN
cord-048322-5eqdrd52	254	47	Antibody	antibody	NN
cord-048322-5eqdrd52	254	48	mediated	mediate	VBN
cord-048322-5eqdrd52	254	49	in	in	IN
cord-048322-5eqdrd52	254	50	vivo	vivo	NN
cord-048322-5eqdrd52	254	51	delivery	delivery	NN
cord-048322-5eqdrd52	254	52	of	of	IN
cord-048322-5eqdrd52	254	53	small	small	JJ
cord-048322-5eqdrd52	254	54	interfering	interfere	VBG
cord-048322-5eqdrd52	254	55	RNAs	rna	NNS
cord-048322-5eqdrd52	254	56	via	via	IN
cord-048322-5eqdrd52	254	57	cell	cell	NN
cord-048322-5eqdrd52	254	58	-	-	HYPH
cord-048322-5eqdrd52	254	59	surface	surface	NN
cord-048322-5eqdrd52	254	60	receptors	receptor	NNS
cord-048322-5eqdrd52	254	61	Silencing	silence	VBG
cord-048322-5eqdrd52	254	62	heat	heat	NN
cord-048322-5eqdrd52	254	63	shock	shock	NN
cord-048322-5eqdrd52	254	64	factor	factor	NN
cord-048322-5eqdrd52	254	65	1	1	CD
cord-048322-5eqdrd52	254	66	by	by	IN
cord-048322-5eqdrd52	254	67	small	small	JJ
cord-048322-5eqdrd52	254	68	interfering	interfere	VBG
cord-048322-5eqdrd52	254	69	RNA	RNA	NNP
cord-048322-5eqdrd52	254	70	abrogates	abrogate	VBZ
cord-048322-5eqdrd52	254	71	heat	heat	NN
cord-048322-5eqdrd52	254	72	shock	shock	NN
cord-048322-5eqdrd52	254	73	-	-	HYPH
cord-048322-5eqdrd52	254	74	induced	induce	VBN
cord-048322-5eqdrd52	254	75	cardioprotection	cardioprotection	NN
cord-048322-5eqdrd52	254	76	against	against	IN
cord-048322-5eqdrd52	254	77	ischemiareperfusion	ischemiareperfusion	NN
cord-048322-5eqdrd52	254	78	injury	injury	NN
cord-048322-5eqdrd52	254	79	in	in	IN
cord-048322-5eqdrd52	254	80	mice	mouse	NNS
cord-048322-5eqdrd52	254	81	Reconstituted	reconstitute	VBN
cord-048322-5eqdrd52	254	82	influenza	influenza	NN
cord-048322-5eqdrd52	254	83	virus	virus	NN
cord-048322-5eqdrd52	254	84	envelopes	envelope	NNS
cord-048322-5eqdrd52	254	85	as	as	IN
cord-048322-5eqdrd52	254	86	an	an	DT
cord-048322-5eqdrd52	254	87	efficient	efficient	JJ
cord-048322-5eqdrd52	254	88	carrier	carrier	NN
cord-048322-5eqdrd52	254	89	system	system	NN
cord-048322-5eqdrd52	254	90	for	for	IN
cord-048322-5eqdrd52	254	91	cellular	cellular	JJ
cord-048322-5eqdrd52	254	92	delivery	delivery	NN
cord-048322-5eqdrd52	254	93	of	of	IN
cord-048322-5eqdrd52	254	94	small	small	RB
cord-048322-5eqdrd52	254	95	-	-	HYPH
cord-048322-5eqdrd52	254	96	interfering	interfere	VBG
cord-048322-5eqdrd52	254	97	RNAs	rna	NNS