id	sid	tid	token	lemma	pos
cord-027654-k0uby99n	1	1	key	key	NN
cord-027654-k0uby99n	1	2	:	:	:
cord-027654-k0uby99n	2	1	cord-027654-k0uby99n	cord-027654-k0uby99n	JJ
cord-027654-k0uby99n	2	2	authors	author	NNS
cord-027654-k0uby99n	2	3	:	:	:
cord-027654-k0uby99n	2	4	Nabel	Nabel	NNP
cord-027654-k0uby99n	2	5	,	,	,
cord-027654-k0uby99n	2	6	Gary	Gary	NNP
cord-027654-k0uby99n	2	7	J.	J.	NNP
cord-027654-k0uby99n	2	8	title	title	NN
cord-027654-k0uby99n	2	9	:	:	:
cord-027654-k0uby99n	2	10	The	the	DT
cord-027654-k0uby99n	2	11	development	development	NN
cord-027654-k0uby99n	2	12	of	of	IN
cord-027654-k0uby99n	2	13	gene	gene	NN
cord-027654-k0uby99n	2	14	-	-	HYPH
cord-027654-k0uby99n	2	15	based	base	VBN
cord-027654-k0uby99n	2	16	vectors	vector	NNS
cord-027654-k0uby99n	2	17	for	for	IN
cord-027654-k0uby99n	2	18	immunization	immunization	NN
cord-027654-k0uby99n	2	19	date	date	NN
cord-027654-k0uby99n	2	20	:	:	:
cord-027654-k0uby99n	2	21	2020	2020	CD
cord-027654-k0uby99n	2	22	-	-	HYPH
cord-027654-k0uby99n	2	23	06	06	CD
cord-027654-k0uby99n	2	24	-	-	SYM
cord-027654-k0uby99n	2	25	22	22	CD
cord-027654-k0uby99n	2	26	journal	journal	NN
cord-027654-k0uby99n	2	27	:	:	:
cord-027654-k0uby99n	3	1	Vaccines	vaccine	NNS
cord-027654-k0uby99n	3	2	DOI	DOI	NNP
cord-027654-k0uby99n	3	3	:	:	:
cord-027654-k0uby99n	3	4	10.1016	10.1016	CD
cord-027654-k0uby99n	3	5	/	/	SYM
cord-027654-k0uby99n	3	6	b978	b978	NNP
cord-027654-k0uby99n	3	7	-	-	HYPH
cord-027654-k0uby99n	3	8	1	1	CD
cord-027654-k0uby99n	3	9	-	-	HYPH
cord-027654-k0uby99n	3	10	4160	4160	CD
cord-027654-k0uby99n	3	11	-	-	HYPH
cord-027654-k0uby99n	3	12	3611	3611	CD
cord-027654-k0uby99n	3	13	-	-	HYPH
cord-027654-k0uby99n	3	14	1.50066	1.50066	CD
cord-027654-k0uby99n	3	15	-	-	SYM
cord-027654-k0uby99n	3	16	0	0	CD
cord-027654-k0uby99n	3	17	sha	sha	NN
cord-027654-k0uby99n	3	18	:	:	:
cord-027654-k0uby99n	4	1	7bd6e3b10fab47eb6060edd3cba1befda32e5624	7bd6e3b10fab47eb6060edd3cba1befda32e5624	NNP
cord-027654-k0uby99n	4	2	doc_id	doc_id	NNP
cord-027654-k0uby99n	4	3	:	:	:
cord-027654-k0uby99n	4	4	27654	27654	CD
cord-027654-k0uby99n	4	5	cord_uid	cord_uid	NNS
cord-027654-k0uby99n	4	6	:	:	:
cord-027654-k0uby99n	5	1	k0uby99n	k0uby99n	NNP
cord-027654-k0uby99n	5	2	nan	nan	NNP
cord-027654-k0uby99n	6	1	The	the	DT
cord-027654-k0uby99n	6	2	development	development	NN
cord-027654-k0uby99n	6	3	of	of	IN
cord-027654-k0uby99n	6	4	DNA	dna	NN
cord-027654-k0uby99n	6	5	vaccines	vaccine	NNS
cord-027654-k0uby99n	6	6	has	have	VBZ
cord-027654-k0uby99n	6	7	evolved	evolve	VBN
cord-027654-k0uby99n	6	8	since	since	IN
cord-027654-k0uby99n	6	9	the	the	DT
cord-027654-k0uby99n	6	10	initial	initial	JJ
cord-027654-k0uby99n	6	11	description	description	NN
cord-027654-k0uby99n	6	12	of	of	IN
cord-027654-k0uby99n	6	13	the	the	DT
cord-027654-k0uby99n	6	14	ability	ability	NN
cord-027654-k0uby99n	6	15	of	of	IN
cord-027654-k0uby99n	6	16	naked	naked	JJ
cord-027654-k0uby99n	6	17	DNA	dna	NN
cord-027654-k0uby99n	6	18	to	to	TO
cord-027654-k0uby99n	6	19	support	support	VB
cord-027654-k0uby99n	6	20	gene	gene	NN
cord-027654-k0uby99n	6	21	expression	expression	NN
cord-027654-k0uby99n	6	22	after	after	IN
cord-027654-k0uby99n	6	23	intramuscular	intramuscular	JJ
cord-027654-k0uby99n	6	24	injection	injection	NN
cord-027654-k0uby99n	6	25	.	.	.
cord-027654-k0uby99n	7	1	3	3	CD
cord-027654-k0uby99n	7	2	,	,	,
cord-027654-k0uby99n	7	3	4	4	CD
cord-027654-k0uby99n	8	1	The	the	DT
cord-027654-k0uby99n	8	2	concept	concept	NN
cord-027654-k0uby99n	8	3	behind	behind	IN
cord-027654-k0uby99n	8	4	these	these	DT
cord-027654-k0uby99n	8	5	vaccines	vaccine	NNS
cord-027654-k0uby99n	8	6	is	be	VBZ
cord-027654-k0uby99n	8	7	that	that	DT
cord-027654-k0uby99n	8	8	expression	expression	NN
cord-027654-k0uby99n	8	9	of	of	IN
cord-027654-k0uby99n	8	10	specifi	specifi	NNP
cord-027654-k0uby99n	8	11	c	c	NNP
cord-027654-k0uby99n	8	12	viral	viral	JJ
cord-027654-k0uby99n	8	13	genes	gene	NNS
cord-027654-k0uby99n	8	14	under	under	IN
cord-027654-k0uby99n	8	15	the	the	DT
cord-027654-k0uby99n	8	16	control	control	NN
cord-027654-k0uby99n	8	17	of	of	IN
cord-027654-k0uby99n	8	18	eukaryotic	eukaryotic	JJ
cord-027654-k0uby99n	8	19	enhancer	enhancer	NN
cord-027654-k0uby99n	8	20	-	-	HYPH
cord-027654-k0uby99n	8	21	promoters	promoter	NNS
cord-027654-k0uby99n	8	22	and	and	CC
cord-027654-k0uby99n	8	23	polyadenylation	polyadenylation	NN
cord-027654-k0uby99n	8	24	signals	signal	NNS
cord-027654-k0uby99n	8	25	allows	allow	VBZ
cord-027654-k0uby99n	8	26	appropriate	appropriate	JJ
cord-027654-k0uby99n	8	27	expression	expression	NN
cord-027654-k0uby99n	8	28	of	of	IN
cord-027654-k0uby99n	8	29	specifi	specifi	NNP
cord-027654-k0uby99n	8	30	c	c	NNP
cord-027654-k0uby99n	8	31	viral	viral	JJ
cord-027654-k0uby99n	8	32	gene	gene	NN
cord-027654-k0uby99n	8	33	products	product	NNS
cord-027654-k0uby99n	8	34	which	which	WDT
cord-027654-k0uby99n	8	35	can	can	MD
cord-027654-k0uby99n	8	36	be	be	VB
cord-027654-k0uby99n	8	37	processed	process	VBN
cord-027654-k0uby99n	8	38	and	and	CC
cord-027654-k0uby99n	8	39	presented	present	VBN
cord-027654-k0uby99n	8	40	as	as	IN
cord-027654-k0uby99n	8	41	foreign	foreign	JJ
cord-027654-k0uby99n	8	42	antigens	antigen	NNS
cord-027654-k0uby99n	8	43	.	.	.
cord-027654-k0uby99n	9	1	The	the	DT
cord-027654-k0uby99n	9	2	genes	gene	NNS
cord-027654-k0uby99n	9	3	encoded	encode	VBN
cord-027654-k0uby99n	9	4	by	by	IN
cord-027654-k0uby99n	9	5	DNA	dna	NN
cord-027654-k0uby99n	9	6	vaccines	vaccine	NNS
cord-027654-k0uby99n	9	7	can	can	MD
cord-027654-k0uby99n	9	8	be	be	VB
cord-027654-k0uby99n	9	9	readily	readily	RB
cord-027654-k0uby99n	9	10	modifi	modifi	JJ
cord-027654-k0uby99n	10	1	ed	ed	NNP
cord-027654-k0uby99n	10	2	and	and	CC
cord-027654-k0uby99n	10	3	regulatory	regulatory	JJ
cord-027654-k0uby99n	10	4	sequences	sequence	NNS
cord-027654-k0uby99n	10	5	can	can	MD
cord-027654-k0uby99n	10	6	be	be	VB
cord-027654-k0uby99n	10	7	adjusted	adjust	VBN
cord-027654-k0uby99n	10	8	to	to	TO
cord-027654-k0uby99n	10	9	optimize	optimize	VB
cord-027654-k0uby99n	10	10	level	level	NN
cord-027654-k0uby99n	10	11	,	,	,
cord-027654-k0uby99n	10	12	duration	duration	NN
cord-027654-k0uby99n	10	13	and	and	CC
cord-027654-k0uby99n	10	14	potency	potency	NN
cord-027654-k0uby99n	10	15	of	of	IN
cord-027654-k0uby99n	10	16	the	the	DT
cord-027654-k0uby99n	10	17	immunogen	immunogen	NN
cord-027654-k0uby99n	10	18	.	.	.
cord-027654-k0uby99n	11	1	5	5	LS
cord-027654-k0uby99n	12	1	When	when	WRB
cord-027654-k0uby99n	12	2	injected	inject	VBN
cord-027654-k0uby99n	12	3	into	into	IN
cord-027654-k0uby99n	12	4	muscle	muscle	NN
cord-027654-k0uby99n	12	5	,	,	,
cord-027654-k0uby99n	12	6	DNA	DNA	NNP
cord-027654-k0uby99n	12	7	is	be	VBZ
cord-027654-k0uby99n	12	8	taken	take	VBN
cord-027654-k0uby99n	12	9	up	up	RP
cord-027654-k0uby99n	12	10	by	by	IN
cord-027654-k0uby99n	12	11	cells	cell	NNS
cord-027654-k0uby99n	12	12	surrounding	surround	VBG
cord-027654-k0uby99n	12	13	the	the	DT
cord-027654-k0uby99n	12	14	injection	injection	NN
cord-027654-k0uby99n	12	15	site	site	NN
cord-027654-k0uby99n	12	16	and	and	CC
cord-027654-k0uby99n	12	17	internalized	internalize	VBN
cord-027654-k0uby99n	12	18	.	.	.
cord-027654-k0uby99n	13	1	After	after	IN
cord-027654-k0uby99n	13	2	uptake	uptake	NN
cord-027654-k0uby99n	13	3	and	and	CC
cord-027654-k0uby99n	13	4	transport	transport	NN
cord-027654-k0uby99n	13	5	to	to	IN
cord-027654-k0uby99n	13	6	the	the	DT
cord-027654-k0uby99n	13	7	nucleus	nucleus	NN
cord-027654-k0uby99n	13	8	,	,	,
cord-027654-k0uby99n	13	9	transcription	transcription	NN
cord-027654-k0uby99n	13	10	,	,	,
cord-027654-k0uby99n	13	11	translation	translation	NN
cord-027654-k0uby99n	13	12	,	,	,
cord-027654-k0uby99n	13	13	and	and	CC
cord-027654-k0uby99n	13	14	post	post	JJ
cord-027654-k0uby99n	13	15	-	-	JJ
cord-027654-k0uby99n	13	16	translational	translational	JJ
cord-027654-k0uby99n	13	17	modifi	modifi	NNP
cord-027654-k0uby99n	13	18	cation	cation	NN
cord-027654-k0uby99n	13	19	allow	allow	VBP
cord-027654-k0uby99n	13	20	for	for	IN
cord-027654-k0uby99n	13	21	the	the	DT
cord-027654-k0uby99n	13	22	synthesis	synthesis	NN
cord-027654-k0uby99n	13	23	of	of	IN
cord-027654-k0uby99n	13	24	a	a	DT
cord-027654-k0uby99n	13	25	specifi	specifi	NN
cord-027654-k0uby99n	13	26	ed	ed	NN
cord-027654-k0uby99n	13	27	gene	gene	NN
cord-027654-k0uby99n	13	28	product	product	NN
cord-027654-k0uby99n	13	29	.	.	.
cord-027654-k0uby99n	14	1	In	in	IN
cord-027654-k0uby99n	14	2	contrast	contrast	NN
cord-027654-k0uby99n	14	3	to	to	IN
cord-027654-k0uby99n	14	4	inactivated	inactivate	VBN
cord-027654-k0uby99n	14	5	virus	virus	NN
cord-027654-k0uby99n	14	6	particles	particle	NNS
cord-027654-k0uby99n	14	7	or	or	CC
cord-027654-k0uby99n	14	8	recombinant	recombinant	JJ
cord-027654-k0uby99n	14	9	protein	protein	NN
cord-027654-k0uby99n	14	10	vaccines	vaccine	NNS
cord-027654-k0uby99n	14	11	produced	produce	VBN
cord-027654-k0uby99n	14	12	in	in	IN
cord-027654-k0uby99n	14	13	bacteria	bacteria	NNS
cord-027654-k0uby99n	14	14	,	,	,
cord-027654-k0uby99n	14	15	yeast	yeast	NN
cord-027654-k0uby99n	14	16	or	or	CC
cord-027654-k0uby99n	14	17	mammalian	mammalian	JJ
cord-027654-k0uby99n	14	18	cells	cell	NNS
cord-027654-k0uby99n	14	19	,	,	,
cord-027654-k0uby99n	14	20	proteins	protein	NNS
cord-027654-k0uby99n	14	21	expressed	express	VBN
cord-027654-k0uby99n	14	22	from	from	IN
cord-027654-k0uby99n	14	23	gene	gene	NN
cord-027654-k0uby99n	14	24	-	-	HYPH
cord-027654-k0uby99n	14	25	based	base	VBN
cord-027654-k0uby99n	14	26	DNA	dna	NN
cord-027654-k0uby99n	14	27	vaccines	vaccine	NNS
cord-027654-k0uby99n	14	28	are	be	VBP
cord-027654-k0uby99n	14	29	more	more	RBR
cord-027654-k0uby99n	14	30	likely	likely	JJ
cord-027654-k0uby99n	14	31	to	to	TO
cord-027654-k0uby99n	14	32	assume	assume	VB
cord-027654-k0uby99n	14	33	a	a	DT
cord-027654-k0uby99n	14	34	native	native	JJ
cord-027654-k0uby99n	14	35	conformation	conformation	NN
cord-027654-k0uby99n	14	36	,	,	,
cord-027654-k0uby99n	14	37	and	and	CC
cord-027654-k0uby99n	14	38	their	-PRON-	PRP$
cord-027654-k0uby99n	14	39	expression	expression	NN
cord-027654-k0uby99n	14	40	within	within	IN
cord-027654-k0uby99n	14	41	cells	cell	NNS
cord-027654-k0uby99n	14	42	allows	allow	VBZ
cord-027654-k0uby99n	14	43	for	for	IN
cord-027654-k0uby99n	14	44	more	more	JJR
cord-027654-k0uby99n	14	45	native	native	JJ
cord-027654-k0uby99n	14	46	processing	processing	NN
cord-027654-k0uby99n	14	47	and	and	CC
cord-027654-k0uby99n	14	48	presentation	presentation	NN
cord-027654-k0uby99n	14	49	of	of	IN
cord-027654-k0uby99n	14	50	antigens	antigen	NNS
cord-027654-k0uby99n	14	51	that	that	WDT
cord-027654-k0uby99n	14	52	can	can	MD
cord-027654-k0uby99n	14	53	stimulate	stimulate	VB
cord-027654-k0uby99n	14	54	CD4	CD4	NNP
cord-027654-k0uby99n	14	55	and	and	CC
cord-027654-k0uby99n	14	56	CD8	CD8	NNP
cord-027654-k0uby99n	14	57	responses	response	NNS
cord-027654-k0uby99n	14	58	in	in	IN
cord-027654-k0uby99n	14	59	vivo	vivo	NN
cord-027654-k0uby99n	14	60	.	.	.
cord-027654-k0uby99n	15	1	Because	because	IN
cord-027654-k0uby99n	15	2	they	-PRON-	PRP
cord-027654-k0uby99n	15	3	are	be	VBP
cord-027654-k0uby99n	15	4	in	in	IN
cord-027654-k0uby99n	15	5	native	native	JJ
cord-027654-k0uby99n	15	6	form	form	NN
cord-027654-k0uby99n	15	7	,	,	,
cord-027654-k0uby99n	15	8	the	the	DT
cord-027654-k0uby99n	15	9	antibodies	antibody	NNS
cord-027654-k0uby99n	15	10	generated	generate	VBN
cord-027654-k0uby99n	15	11	against	against	IN
cord-027654-k0uby99n	15	12	these	these	DT
cord-027654-k0uby99n	15	13	immunogens	immunogen	NNS
cord-027654-k0uby99n	15	14	are	be	VBP
cord-027654-k0uby99n	15	15	theoretically	theoretically	RB
cord-027654-k0uby99n	15	16	more	more	RBR
cord-027654-k0uby99n	15	17	likely	likely	JJ
cord-027654-k0uby99n	15	18	to	to	TO
cord-027654-k0uby99n	15	19	be	be	VB
cord-027654-k0uby99n	15	20	cross	cross	JJ
cord-027654-k0uby99n	15	21	-	-	JJ
cord-027654-k0uby99n	15	22	reactive	reactive	JJ
cord-027654-k0uby99n	15	23	with	with	IN
cord-027654-k0uby99n	15	24	native	native	JJ
cord-027654-k0uby99n	15	25	viral	viral	JJ
cord-027654-k0uby99n	15	26	gene	gene	NN
cord-027654-k0uby99n	15	27	products	product	NNS
cord-027654-k0uby99n	15	28	from	from	IN
cord-027654-k0uby99n	15	29	the	the	DT
cord-027654-k0uby99n	15	30	pathogen	pathogen	NN
cord-027654-k0uby99n	15	31	.	.	.
cord-027654-k0uby99n	16	1	In	in	IN
cord-027654-k0uby99n	16	2	addition	addition	NN
cord-027654-k0uby99n	16	3	,	,	,
cord-027654-k0uby99n	16	4	because	because	IN
cord-027654-k0uby99n	16	5	DNA	DNA	NNP
cord-027654-k0uby99n	16	6	is	be	VBZ
cord-027654-k0uby99n	16	7	rapidly	rapidly	RB
cord-027654-k0uby99n	16	8	degraded	degrade	VBN
cord-027654-k0uby99n	16	9	in	in	IN
cord-027654-k0uby99n	16	10	the	the	DT
cord-027654-k0uby99n	16	11	body	body	NN
cord-027654-k0uby99n	16	12	,	,	,
cord-027654-k0uby99n	16	13	the	the	DT
cord-027654-k0uby99n	16	14	plasmid	plasmid	NN
cord-027654-k0uby99n	16	15	DNA	dna	NN
cord-027654-k0uby99n	16	16	vaccines	vaccine	NNS
cord-027654-k0uby99n	16	17	can	can	MD
cord-027654-k0uby99n	16	18	provide	provide	VB
cord-027654-k0uby99n	16	19	an	an	DT
cord-027654-k0uby99n	16	20	advantage	advantage	NN
cord-027654-k0uby99n	16	21	in	in	IN
cord-027654-k0uby99n	16	22	terms	term	NNS
cord-027654-k0uby99n	16	23	of	of	IN
cord-027654-k0uby99n	16	24	safety	safety	NN
cord-027654-k0uby99n	16	25	,	,	,
cord-027654-k0uby99n	16	26	in	in	IN
cord-027654-k0uby99n	16	27	contrast	contrast	NN
cord-027654-k0uby99n	16	28	to	to	IN
cord-027654-k0uby99n	16	29	live	live	VB
cord-027654-k0uby99n	16	30	-	-	HYPH
cord-027654-k0uby99n	16	31	attenuated	attenuate	VBN
cord-027654-k0uby99n	16	32	viruses	virus	NNS
cord-027654-k0uby99n	16	33	,	,	,
cord-027654-k0uby99n	16	34	with	with	IN
cord-027654-k0uby99n	16	35	the	the	DT
cord-027654-k0uby99n	16	36	possibility	possibility	NN
cord-027654-k0uby99n	16	37	of	of	IN
cord-027654-k0uby99n	16	38	chronic	chronic	JJ
cord-027654-k0uby99n	16	39	infection	infection	NN
cord-027654-k0uby99n	16	40	and	and	CC
cord-027654-k0uby99n	16	41	immune	immune	JJ
cord-027654-k0uby99n	16	42	stimulation	stimulation	NN
cord-027654-k0uby99n	16	43	.	.	.
cord-027654-k0uby99n	17	1	The	the	DT
cord-027654-k0uby99n	17	2	application	application	NN
cord-027654-k0uby99n	17	3	of	of	IN
cord-027654-k0uby99n	17	4	DNA	dna	NN
cord-027654-k0uby99n	17	5	-	-	HYPH
cord-027654-k0uby99n	17	6	based	base	VBN
cord-027654-k0uby99n	17	7	genetic	genetic	JJ
cord-027654-k0uby99n	17	8	immunization	immunization	NN
cord-027654-k0uby99n	17	9	has	have	VBZ
cord-027654-k0uby99n	17	10	now	now	RB
cord-027654-k0uby99n	17	11	been	be	VBN
cord-027654-k0uby99n	17	12	demonstrated	demonstrate	VBN
cord-027654-k0uby99n	17	13	in	in	IN
cord-027654-k0uby99n	17	14	a	a	DT
cord-027654-k0uby99n	17	15	variety	variety	NN
cord-027654-k0uby99n	17	16	of	of	IN
cord-027654-k0uby99n	17	17	animal	animal	NN
cord-027654-k0uby99n	17	18	models	model	NNS
cord-027654-k0uby99n	17	19	.	.	.
cord-027654-k0uby99n	18	1	[	[	-LRB-
cord-027654-k0uby99n	18	2	6	6	CD
cord-027654-k0uby99n	18	3	]	]	-RRB-
cord-027654-k0uby99n	18	4	[	[	-LRB-
cord-027654-k0uby99n	18	5	7	7	CD
cord-027654-k0uby99n	18	6	]	]	-RRB-
cord-027654-k0uby99n	18	7	[	[	-LRB-
cord-027654-k0uby99n	18	8	8	8	CD
cord-027654-k0uby99n	18	9	]	]	-RRB-
cord-027654-k0uby99n	19	1	In	in	IN
cord-027654-k0uby99n	19	2	addition	addition	NN
cord-027654-k0uby99n	19	3	,	,	,
cord-027654-k0uby99n	19	4	in	in	IN
cord-027654-k0uby99n	19	5	animals	animal	NNS
cord-027654-k0uby99n	19	6	it	-PRON-	PRP
cord-027654-k0uby99n	19	7	has	have	VBZ
cord-027654-k0uby99n	19	8	been	be	VBN
cord-027654-k0uby99n	19	9	shown	show	VBN
cord-027654-k0uby99n	19	10	to	to	TO
cord-027654-k0uby99n	19	11	be	be	VB
cord-027654-k0uby99n	19	12	effective	effective	JJ
cord-027654-k0uby99n	19	13	in	in	IN
cord-027654-k0uby99n	19	14	inducing	induce	VBG
cord-027654-k0uby99n	19	15	protective	protective	JJ
cord-027654-k0uby99n	19	16	immunity	immunity	NN
cord-027654-k0uby99n	19	17	against	against	IN
cord-027654-k0uby99n	19	18	infl	infl	NNP
cord-027654-k0uby99n	19	19	uenza	uenza	NNP
cord-027654-k0uby99n	19	20	virus	virus	NN
cord-027654-k0uby99n	19	21	,	,	,
cord-027654-k0uby99n	19	22	4	4	CD
cord-027654-k0uby99n	19	23	malaria	malaria	NN
cord-027654-k0uby99n	19	24	,	,	,
cord-027654-k0uby99n	19	25	[	[	-LRB-
cord-027654-k0uby99n	19	26	9	9	CD
cord-027654-k0uby99n	19	27	]	]	-RRB-
cord-027654-k0uby99n	19	28	[	[	-LRB-
cord-027654-k0uby99n	19	29	10	10	CD
cord-027654-k0uby99n	19	30	]	]	-RRB-
cord-027654-k0uby99n	19	31	[	[	-LRB-
cord-027654-k0uby99n	19	32	11	11	CD
cord-027654-k0uby99n	19	33	]	]	-RRB-
cord-027654-k0uby99n	19	34	[	[	-LRB-
cord-027654-k0uby99n	19	35	12	12	CD
cord-027654-k0uby99n	19	36	]	]	-RRB-
cord-027654-k0uby99n	19	37	tuberculosis	tuberculosis	NN
cord-027654-k0uby99n	19	38	,	,	,
cord-027654-k0uby99n	19	39	13	13	CD
cord-027654-k0uby99n	19	40	Ebola	Ebola	NNP
cord-027654-k0uby99n	19	41	virus	virus	NN
cord-027654-k0uby99n	19	42	,	,	,
cord-027654-k0uby99n	19	43	14	14	CD
cord-027654-k0uby99n	19	44	rabies	rabie	NNS
cord-027654-k0uby99n	19	45	,	,	,
cord-027654-k0uby99n	19	46	15	15	CD
cord-027654-k0uby99n	19	47	lymphocytic	lymphocytic	JJ
cord-027654-k0uby99n	19	48	choriomeningitis	choriomeningitis	NNP
cord-027654-k0uby99n	19	49	virus	virus	NN
cord-027654-k0uby99n	19	50	,	,	,
cord-027654-k0uby99n	19	51	16,17	16,17	CD
cord-027654-k0uby99n	19	52	herpes	herpes	NN
cord-027654-k0uby99n	19	53	simplex	simplex	NN
cord-027654-k0uby99n	19	54	virus	virus	NN
cord-027654-k0uby99n	19	55	18	18	CD
cord-027654-k0uby99n	19	56	and	and	CC
cord-027654-k0uby99n	19	57	lentiviruses	lentiviruse	VBZ
cord-027654-k0uby99n	19	58	19	19	CD
cord-027654-k0uby99n	19	59	in	in	IN
cord-027654-k0uby99n	19	60	addition	addition	NN
cord-027654-k0uby99n	19	61	to	to	IN
cord-027654-k0uby99n	19	62	other	other	JJ
cord-027654-k0uby99n	19	63	pathogens	pathogen	NNS
cord-027654-k0uby99n	19	64	.	.	.
cord-027654-k0uby99n	20	1	Studies	study	NNS
cord-027654-k0uby99n	20	2	in	in	IN
cord-027654-k0uby99n	20	3	nonhuman	nonhuman	NN
cord-027654-k0uby99n	20	4	primates	primate	NNS
cord-027654-k0uby99n	20	5	and	and	CC
cord-027654-k0uby99n	20	6	humans	human	NNS
cord-027654-k0uby99n	20	7	have	have	VBP
cord-027654-k0uby99n	20	8	indicated	indicate	VBN
cord-027654-k0uby99n	20	9	that	that	IN
cord-027654-k0uby99n	20	10	the	the	DT
cord-027654-k0uby99n	20	11	approach	approach	NN
cord-027654-k0uby99n	20	12	is	be	VBZ
cord-027654-k0uby99n	20	13	effective	effective	JJ
cord-027654-k0uby99n	20	14	in	in	IN
cord-027654-k0uby99n	20	15	inducing	induce	VBG
cord-027654-k0uby99n	20	16	CTL	CTL	NNP
cord-027654-k0uby99n	20	17	responses	response	NNS
cord-027654-k0uby99n	20	18	(	(	-LRB-
cord-027654-k0uby99n	20	19	20	20	CD
cord-027654-k0uby99n	20	20	and	and	CC
cord-027654-k0uby99n	20	21	Graham	Graham	NNP
cord-027654-k0uby99n	20	22	et	et	NNP
cord-027654-k0uby99n	20	23	al	al	NNP
cord-027654-k0uby99n	20	24	,	,	,
cord-027654-k0uby99n	20	25	unpublished	unpublished	JJ
cord-027654-k0uby99n	20	26	data	datum	NNS
cord-027654-k0uby99n	20	27	)	)	-RRB-
cord-027654-k0uby99n	20	28	.	.	.
cord-027654-k0uby99n	21	1	DNA	dna	NN
cord-027654-k0uby99n	21	2	vaccines	vaccine	NNS
cord-027654-k0uby99n	21	3	have	have	VBP
cord-027654-k0uby99n	21	4	also	also	RB
cord-027654-k0uby99n	21	5	been	be	VBN
cord-027654-k0uby99n	21	6	used	use	VBN
cord-027654-k0uby99n	21	7	successfully	successfully	RB
cord-027654-k0uby99n	21	8	alone	alone	JJ
cord-027654-k0uby99n	21	9	or	or	CC
cord-027654-k0uby99n	21	10	in	in	IN
cord-027654-k0uby99n	21	11	combination	combination	NN
cord-027654-k0uby99n	21	12	with	with	IN
cord-027654-k0uby99n	21	13	other	other	JJ
cord-027654-k0uby99n	21	14	gene	gene	NN
cord-027654-k0uby99n	21	15	-	-	HYPH
cord-027654-k0uby99n	21	16	based	base	VBN
cord-027654-k0uby99n	21	17	approaches	approach	NNS
cord-027654-k0uby99n	21	18	to	to	TO
cord-027654-k0uby99n	21	19	develop	develop	VB
cord-027654-k0uby99n	21	20	protective	protective	JJ
cord-027654-k0uby99n	21	21	immunity	immunity	NN
cord-027654-k0uby99n	21	22	against	against	IN
cord-027654-k0uby99n	21	23	pathogenic	pathogenic	JJ
cord-027654-k0uby99n	21	24	SHIV	SHIV	NNP
cord-027654-k0uby99n	21	25	and	and	CC
cord-027654-k0uby99n	21	26	SIV	SIV	NNP
cord-027654-k0uby99n	21	27	challenge	challenge	NN
cord-027654-k0uby99n	21	28	.	.	.
cord-027654-k0uby99n	22	1	19,21	19,21	CD
cord-027654-k0uby99n	22	2	-	-	SYM
cord-027654-k0uby99n	22	3	27	27	CD
cord-027654-k0uby99n	22	4	Various	various	JJ
cord-027654-k0uby99n	22	5	prime	prime	JJ
cord-027654-k0uby99n	22	6	-	-	HYPH
cord-027654-k0uby99n	22	7	boost	boost	NN
cord-027654-k0uby99n	22	8	strategies	strategy	NNS
cord-027654-k0uby99n	22	9	have	have	VBP
cord-027654-k0uby99n	22	10	utilized	utilize	VBN
cord-027654-k0uby99n	22	11	Gary	Gary	NNP
cord-027654-k0uby99n	22	12	J.	J.	NNP
cord-027654-k0uby99n	22	13	Nabel	Nabel	NNP
cord-027654-k0uby99n	22	14	Vaccines	vaccine	NNS
cord-027654-k0uby99n	22	15	can	can	MD
cord-027654-k0uby99n	22	16	confer	confer	VB
cord-027654-k0uby99n	22	17	immune	immune	JJ
cord-027654-k0uby99n	22	18	protection	protection	NN
cord-027654-k0uby99n	22	19	against	against	IN
cord-027654-k0uby99n	22	20	infectious	infectious	JJ
cord-027654-k0uby99n	22	21	agents	agent	NNS
cord-027654-k0uby99n	22	22	through	through	IN
cord-027654-k0uby99n	22	23	divergent	divergent	JJ
cord-027654-k0uby99n	22	24	arms	arm	NNS
cord-027654-k0uby99n	22	25	of	of	IN
cord-027654-k0uby99n	22	26	the	the	DT
cord-027654-k0uby99n	22	27	adaptive	adaptive	JJ
cord-027654-k0uby99n	22	28	immune	immune	JJ
cord-027654-k0uby99n	22	29	response	response	NN
cord-027654-k0uby99n	22	30	.	.	.
cord-027654-k0uby99n	23	1	The	the	DT
cord-027654-k0uby99n	23	2	elaboration	elaboration	NN
cord-027654-k0uby99n	23	3	of	of	IN
cord-027654-k0uby99n	23	4	antibodies	antibody	NNS
cord-027654-k0uby99n	23	5	through	through	IN
cord-027654-k0uby99n	23	6	the	the	DT
cord-027654-k0uby99n	23	7	humoral	humoral	JJ
cord-027654-k0uby99n	23	8	immune	immune	JJ
cord-027654-k0uby99n	23	9	system	system	NN
cord-027654-k0uby99n	23	10	has	have	VBZ
cord-027654-k0uby99n	23	11	been	be	VBN
cord-027654-k0uby99n	23	12	highly	highly	RB
cord-027654-k0uby99n	23	13	effective	effective	JJ
cord-027654-k0uby99n	23	14	in	in	IN
cord-027654-k0uby99n	23	15	the	the	DT
cord-027654-k0uby99n	23	16	neutralization	neutralization	NN
cord-027654-k0uby99n	23	17	of	of	IN
cord-027654-k0uby99n	23	18	many	many	JJ
cord-027654-k0uby99n	23	19	bacteria	bacteria	NNS
cord-027654-k0uby99n	23	20	,	,	,
cord-027654-k0uby99n	23	21	viruses	virus	NNS
cord-027654-k0uby99n	23	22	,	,	,
cord-027654-k0uby99n	23	23	fungi	fungus	NNS
cord-027654-k0uby99n	23	24	and	and	CC
cord-027654-k0uby99n	23	25	parasites	parasite	NNS
cord-027654-k0uby99n	23	26	.	.	.
cord-027654-k0uby99n	24	1	The	the	DT
cord-027654-k0uby99n	24	2	cell	cell	NN
cord-027654-k0uby99n	24	3	-	-	HYPH
cord-027654-k0uby99n	24	4	mediated	mediate	VBN
cord-027654-k0uby99n	24	5	immune	immune	JJ
cord-027654-k0uby99n	24	6	response	response	NN
cord-027654-k0uby99n	24	7	also	also	RB
cord-027654-k0uby99n	24	8	plays	play	VBZ
cord-027654-k0uby99n	24	9	a	a	DT
cord-027654-k0uby99n	24	10	major	major	JJ
cord-027654-k0uby99n	24	11	role	role	NN
cord-027654-k0uby99n	24	12	in	in	IN
cord-027654-k0uby99n	24	13	containment	containment	NN
cord-027654-k0uby99n	24	14	of	of	IN
cord-027654-k0uby99n	24	15	infectious	infectious	JJ
cord-027654-k0uby99n	24	16	agents	agent	NNS
cord-027654-k0uby99n	24	17	.	.	.
cord-027654-k0uby99n	25	1	T	T	NNP
cord-027654-k0uby99n	25	2	lymphocytes	lymphocyte	NNS
cord-027654-k0uby99n	25	3	comprise	comprise	VBP
cord-027654-k0uby99n	25	4	a	a	DT
cord-027654-k0uby99n	25	5	diverse	diverse	JJ
cord-027654-k0uby99n	25	6	set	set	NN
cord-027654-k0uby99n	25	7	of	of	IN
cord-027654-k0uby99n	25	8	cells	cell	NNS
cord-027654-k0uby99n	25	9	,	,	,
cord-027654-k0uby99n	25	10	and	and	CC
cord-027654-k0uby99n	25	11	their	-PRON-	PRP$
cord-027654-k0uby99n	25	12	functional	functional	JJ
cord-027654-k0uby99n	25	13	activity	activity	NN
cord-027654-k0uby99n	25	14	is	be	VBZ
cord-027654-k0uby99n	25	15	dependent	dependent	JJ
cord-027654-k0uby99n	25	16	upon	upon	IN
cord-027654-k0uby99n	25	17	helper	helper	NN
cord-027654-k0uby99n	25	18	T	t	NN
cord-027654-k0uby99n	25	19	cells	cell	NNS
cord-027654-k0uby99n	25	20	,	,	,
cord-027654-k0uby99n	25	21	which	which	WDT
cord-027654-k0uby99n	25	22	elaborate	elaborate	VBP
cord-027654-k0uby99n	25	23	a	a	DT
cord-027654-k0uby99n	25	24	variety	variety	NN
cord-027654-k0uby99n	25	25	of	of	IN
cord-027654-k0uby99n	25	26	cytokines	cytokine	NNS
cord-027654-k0uby99n	25	27	and	and	CC
cord-027654-k0uby99n	25	28	stimulate	stimulate	VB
cord-027654-k0uby99n	25	29	B	b	NN
cord-027654-k0uby99n	25	30	cells	cell	NNS
cord-027654-k0uby99n	25	31	to	to	TO
cord-027654-k0uby99n	25	32	produce	produce	VB
cord-027654-k0uby99n	25	33	antibodies	antibody	NNS
cord-027654-k0uby99n	25	34	and	and	CC
cord-027654-k0uby99n	25	35	induce	induce	VB
cord-027654-k0uby99n	25	36	the	the	DT
cord-027654-k0uby99n	25	37	formation	formation	NN
cord-027654-k0uby99n	25	38	of	of	IN
cord-027654-k0uby99n	25	39	cytolytic	cytolytic	JJ
cord-027654-k0uby99n	25	40	T	t	NN
cord-027654-k0uby99n	25	41	lymphocytes	lymphocyte	NNS
cord-027654-k0uby99n	25	42	(	(	-LRB-
cord-027654-k0uby99n	25	43	CTL	CTL	NNP
cord-027654-k0uby99n	25	44	)	)	-RRB-
cord-027654-k0uby99n	25	45	.	.	.
cord-027654-k0uby99n	26	1	CTLs	ctl	NNS
cord-027654-k0uby99n	26	2	recognize	recognize	VBP
cord-027654-k0uby99n	26	3	processed	process	VBN
cord-027654-k0uby99n	26	4	antigen	antigen	NN
cord-027654-k0uby99n	26	5	on	on	IN
cord-027654-k0uby99n	26	6	major	major	JJ
cord-027654-k0uby99n	26	7	histocompatibility	histocompatibility	NN
cord-027654-k0uby99n	26	8	complex	complex	NN
cord-027654-k0uby99n	26	9	(	(	-LRB-
cord-027654-k0uby99n	26	10	MHC	MHC	NNP
cord-027654-k0uby99n	26	11	)	)	-RRB-
cord-027654-k0uby99n	26	12	molecules	molecule	NNS
cord-027654-k0uby99n	26	13	and	and	CC
cord-027654-k0uby99n	26	14	lyse	lyse	VB
cord-027654-k0uby99n	26	15	infected	infected	JJ
cord-027654-k0uby99n	26	16	cells	cell	NNS
cord-027654-k0uby99n	26	17	.	.	.
cord-027654-k0uby99n	27	1	Both	both	DT
cord-027654-k0uby99n	27	2	humoral	humoral	JJ
cord-027654-k0uby99n	27	3	and	and	CC
cord-027654-k0uby99n	27	4	cellular	cellular	JJ
cord-027654-k0uby99n	27	5	immunity	immunity	NN
cord-027654-k0uby99n	27	6	are	be	VBP
cord-027654-k0uby99n	27	7	the	the	DT
cord-027654-k0uby99n	27	8	targets	target	NNS
cord-027654-k0uby99n	27	9	of	of	IN
cord-027654-k0uby99n	27	10	vaccine	vaccine	NN
cord-027654-k0uby99n	27	11	-	-	HYPH
cord-027654-k0uby99n	27	12	induced	induce	VBN
cord-027654-k0uby99n	27	13	immunological	immunological	JJ
cord-027654-k0uby99n	27	14	responses	response	NNS
cord-027654-k0uby99n	27	15	,	,	,
cord-027654-k0uby99n	27	16	each	each	DT
cord-027654-k0uby99n	27	17	with	with	IN
cord-027654-k0uby99n	27	18	its	-PRON-	PRP$
cord-027654-k0uby99n	27	19	own	own	JJ
cord-027654-k0uby99n	27	20	effector	effector	NN
cord-027654-k0uby99n	27	21	functions	function	NNS
cord-027654-k0uby99n	27	22	that	that	WDT
cord-027654-k0uby99n	27	23	can	can	MD
cord-027654-k0uby99n	27	24	inactivate	inactivate	VB
cord-027654-k0uby99n	27	25	pathogens	pathogen	NNS
cord-027654-k0uby99n	27	26	in	in	IN
cord-027654-k0uby99n	27	27	different	different	JJ
cord-027654-k0uby99n	27	28	ways	way	NNS
cord-027654-k0uby99n	27	29	(	(	-LRB-
cord-027654-k0uby99n	27	30	Table	Table	NNP
cord-027654-k0uby99n	27	31	62	62	CD
cord-027654-k0uby99n	27	32	-	-	SYM
cord-027654-k0uby99n	27	33	1	1	CD
cord-027654-k0uby99n	27	34	)	)	-RRB-
cord-027654-k0uby99n	27	35	.	.	.
cord-027654-k0uby99n	28	1	While	while	IN
cord-027654-k0uby99n	28	2	the	the	DT
cord-027654-k0uby99n	28	3	humoral	humoral	JJ
cord-027654-k0uby99n	28	4	immune	immune	JJ
cord-027654-k0uby99n	28	5	response	response	NN
cord-027654-k0uby99n	28	6	is	be	VBZ
cord-027654-k0uby99n	28	7	wellknown	wellknown	JJ
cord-027654-k0uby99n	28	8	to	to	TO
cord-027654-k0uby99n	28	9	confer	confer	VB
cord-027654-k0uby99n	28	10	protection	protection	NN
cord-027654-k0uby99n	28	11	,	,	,
cord-027654-k0uby99n	28	12	the	the	DT
cord-027654-k0uby99n	28	13	role	role	NN
cord-027654-k0uby99n	28	14	of	of	IN
cord-027654-k0uby99n	28	15	CTL	CTL	NNP
cord-027654-k0uby99n	28	16	in	in	IN
cord-027654-k0uby99n	28	17	protective	protective	JJ
cord-027654-k0uby99n	28	18	immunity	immunity	NN
cord-027654-k0uby99n	28	19	against	against	IN
cord-027654-k0uby99n	28	20	viral	viral	JJ
cord-027654-k0uby99n	28	21	infections	infection	NNS
cord-027654-k0uby99n	28	22	has	have	VBZ
cord-027654-k0uby99n	28	23	been	be	VBN
cord-027654-k0uby99n	28	24	recognized	recognize	VBN
cord-027654-k0uby99n	28	25	more	more	RBR
cord-027654-k0uby99n	28	26	recently	recently	RB
cord-027654-k0uby99n	28	27	.	.	.
cord-027654-k0uby99n	29	1	The	the	DT
cord-027654-k0uby99n	29	2	function	function	NN
cord-027654-k0uby99n	29	3	and	and	CC
cord-027654-k0uby99n	29	4	specifi	specifi	VBN
cord-027654-k0uby99n	29	5	city	city	NN
cord-027654-k0uby99n	29	6	of	of	IN
cord-027654-k0uby99n	29	7	these	these	DT
cord-027654-k0uby99n	29	8	cells	cell	NNS
cord-027654-k0uby99n	29	9	has	have	VBZ
cord-027654-k0uby99n	29	10	provided	provide	VBN
cord-027654-k0uby99n	29	11	the	the	DT
cord-027654-k0uby99n	29	12	foundation	foundation	NN
cord-027654-k0uby99n	29	13	for	for	IN
cord-027654-k0uby99n	29	14	understanding	understand	VBG
cord-027654-k0uby99n	29	15	MHC	MHC	NNP
cord-027654-k0uby99n	29	16	restriction	restriction	NN
cord-027654-k0uby99n	29	17	and	and	CC
cord-027654-k0uby99n	29	18	its	-PRON-	PRP$
cord-027654-k0uby99n	29	19	importance	importance	NN
cord-027654-k0uby99n	29	20	in	in	IN
cord-027654-k0uby99n	29	21	protection	protection	NN
cord-027654-k0uby99n	29	22	against	against	IN
cord-027654-k0uby99n	29	23	viral	viral	JJ
cord-027654-k0uby99n	29	24	infection	infection	NN
cord-027654-k0uby99n	29	25	.	.	.
cord-027654-k0uby99n	30	1	1,2	1,2	LS
cord-027654-k0uby99n	31	1	Such	such	JJ
cord-027654-k0uby99n	31	2	cellular	cellular	JJ
cord-027654-k0uby99n	31	3	immune	immune	JJ
cord-027654-k0uby99n	31	4	responses	response	NNS
cord-027654-k0uby99n	31	5	help	help	VBP
cord-027654-k0uby99n	31	6	control	control	VB
cord-027654-k0uby99n	31	7	infectious	infectious	JJ
cord-027654-k0uby99n	31	8	diseases	disease	NNS
cord-027654-k0uby99n	31	9	,	,	,
cord-027654-k0uby99n	31	10	particularly	particularly	RB
cord-027654-k0uby99n	31	11	when	when	WRB
cord-027654-k0uby99n	31	12	it	-PRON-	PRP
cord-027654-k0uby99n	31	13	is	be	VBZ
cord-027654-k0uby99n	31	14	diffi	diffi	JJ
cord-027654-k0uby99n	31	15	cult	cult	NN
cord-027654-k0uby99n	31	16	to	to	TO
cord-027654-k0uby99n	31	17	generate	generate	VB
cord-027654-k0uby99n	31	18	neutralizing	neutralize	VBG
cord-027654-k0uby99n	31	19	antibodies	antibody	NNS
cord-027654-k0uby99n	31	20	,	,	,
cord-027654-k0uby99n	31	21	as	as	IN
cord-027654-k0uby99n	31	22	in	in	IN
cord-027654-k0uby99n	31	23	HIV	HIV	NNP
cord-027654-k0uby99n	31	24	/	/	SYM
cord-027654-k0uby99n	31	25	AIDS	AIDS	NNP
cord-027654-k0uby99n	31	26	,	,	,
cord-027654-k0uby99n	31	27	malaria	malaria	NN
cord-027654-k0uby99n	31	28	and	and	CC
cord-027654-k0uby99n	31	29	tuberculosis	tuberculosis	NN
cord-027654-k0uby99n	31	30	.	.	.
cord-027654-k0uby99n	32	1	Humoral	humoral	JJ
cord-027654-k0uby99n	32	2	immunity	immunity	NN
cord-027654-k0uby99n	32	3	is	be	VBZ
cord-027654-k0uby99n	32	4	more	more	RBR
cord-027654-k0uby99n	32	5	readily	readily	RB
cord-027654-k0uby99n	32	6	induced	induce	VBN
cord-027654-k0uby99n	32	7	with	with	IN
cord-027654-k0uby99n	32	8	purifi	purifi	NNP
cord-027654-k0uby99n	32	9	ed	ed	NNP
cord-027654-k0uby99n	32	10	proteins	protein	NNS
cord-027654-k0uby99n	32	11	or	or	CC
cord-027654-k0uby99n	32	12	inactivated	inactivate	VBN
cord-027654-k0uby99n	32	13	viruses	virus	NNS
cord-027654-k0uby99n	32	14	together	together	RB
cord-027654-k0uby99n	32	15	with	with	IN
cord-027654-k0uby99n	32	16	appropriate	appropriate	JJ
cord-027654-k0uby99n	32	17	adjuvants	adjuvant	NNS
cord-027654-k0uby99n	32	18	;	;	:
cord-027654-k0uby99n	32	19	gene	gene	NN
cord-027654-k0uby99n	32	20	-	-	HYPH
cord-027654-k0uby99n	32	21	based	base	VBN
cord-027654-k0uby99n	32	22	vaccines	vaccine	NNS
cord-027654-k0uby99n	32	23	appear	appear	VBP
cord-027654-k0uby99n	32	24	to	to	TO
cord-027654-k0uby99n	32	25	be	be	VB
cord-027654-k0uby99n	32	26	particularly	particularly	RB
cord-027654-k0uby99n	32	27	effective	effective	JJ
cord-027654-k0uby99n	32	28	at	at	IN
cord-027654-k0uby99n	32	29	inducing	induce	VBG
cord-027654-k0uby99n	32	30	T	t	NN
cord-027654-k0uby99n	32	31	cell	cell	NN
cord-027654-k0uby99n	32	32	responses	response	NNS
cord-027654-k0uby99n	32	33	,	,	,
cord-027654-k0uby99n	32	34	both	both	CC
cord-027654-k0uby99n	32	35	CD4	CD4	NNP
cord-027654-k0uby99n	32	36	and	and	CC
cord-027654-k0uby99n	32	37	CD8	CD8	NNP
cord-027654-k0uby99n	32	38	.	.	.
cord-027654-k0uby99n	33	1	At	at	IN
cord-027654-k0uby99n	33	2	the	the	DT
cord-027654-k0uby99n	33	3	same	same	JJ
cord-027654-k0uby99n	33	4	time	time	NN
cord-027654-k0uby99n	33	5	,	,	,
cord-027654-k0uby99n	33	6	some	some	DT
cord-027654-k0uby99n	33	7	genebased	genebase	VBN
cord-027654-k0uby99n	33	8	vaccines	vaccine	NNS
cord-027654-k0uby99n	33	9	can	can	MD
cord-027654-k0uby99n	33	10	induce	induce	VB
cord-027654-k0uby99n	33	11	humoral	humoral	JJ
cord-027654-k0uby99n	33	12	immune	immune	JJ
cord-027654-k0uby99n	33	13	responses	response	NNS
cord-027654-k0uby99n	33	14	when	when	WRB
cord-027654-k0uby99n	33	15	used	use	VBN
cord-027654-k0uby99n	33	16	with	with	IN
cord-027654-k0uby99n	33	17	specifi	specifi	NNP
cord-027654-k0uby99n	33	18	c	c	NN
cord-027654-k0uby99n	33	19	vectors	vector	NNS
cord-027654-k0uby99n	33	20	or	or	CC
cord-027654-k0uby99n	33	21	in	in	IN
cord-027654-k0uby99n	33	22	specifi	specifi	NNP
cord-027654-k0uby99n	33	23	c	c	NNP
cord-027654-k0uby99n	33	24	prime	prime	JJ
cord-027654-k0uby99n	33	25	-	-	HYPH
cord-027654-k0uby99n	33	26	boost	boost	NN
cord-027654-k0uby99n	33	27	combinations	combination	NNS
cord-027654-k0uby99n	33	28	.	.	.
cord-027654-k0uby99n	34	1	The	the	DT
cord-027654-k0uby99n	34	2	majority	majority	NN
cord-027654-k0uby99n	34	3	of	of	IN
cord-027654-k0uby99n	34	4	adjuvants	adjuvant	NNS
cord-027654-k0uby99n	34	5	that	that	WDT
cord-027654-k0uby99n	34	6	have	have	VBP
cord-027654-k0uby99n	34	7	been	be	VBN
cord-027654-k0uby99n	34	8	utilized	utilize	VBN
cord-027654-k0uby99n	34	9	in	in	IN
cord-027654-k0uby99n	34	10	vaccine	vaccine	NN
cord-027654-k0uby99n	34	11	development	development	NN
cord-027654-k0uby99n	34	12	have	have	VBP
cord-027654-k0uby99n	34	13	affected	affect	VBN
cord-027654-k0uby99n	34	14	humoral	humoral	JJ
cord-027654-k0uby99n	34	15	immunity	immunity	NN
cord-027654-k0uby99n	34	16	and	and	CC
cord-027654-k0uby99n	34	17	appear	appear	VBP
cord-027654-k0uby99n	34	18	to	to	TO
cord-027654-k0uby99n	34	19	enhance	enhance	VB
cord-027654-k0uby99n	34	20	antibody	antibody	NN
cord-027654-k0uby99n	34	21	responses	response	NNS
cord-027654-k0uby99n	34	22	without	without	IN
cord-027654-k0uby99n	34	23	inducing	induce	VBG
cord-027654-k0uby99n	34	24	cellular	cellular	JJ
cord-027654-k0uby99n	34	25	immunity	immunity	NN
cord-027654-k0uby99n	34	26	.	.	.
cord-027654-k0uby99n	35	1	In	in	IN
cord-027654-k0uby99n	35	2	contrast	contrast	NN
cord-027654-k0uby99n	35	3	,	,	,
cord-027654-k0uby99n	35	4	the	the	DT
cord-027654-k0uby99n	35	5	gene	gene	NN
cord-027654-k0uby99n	35	6	-	-	HYPH
cord-027654-k0uby99n	35	7	based	base	VBN
cord-027654-k0uby99n	35	8	delivery	delivery	NN
cord-027654-k0uby99n	35	9	of	of	IN
cord-027654-k0uby99n	35	10	vaccine	vaccine	NN
cord-027654-k0uby99n	35	11	vectors	vector	NNS
cord-027654-k0uby99n	35	12	can	can	MD
cord-027654-k0uby99n	35	13	stimulate	stimulate	VB
cord-027654-k0uby99n	35	14	both	both	DT
cord-027654-k0uby99n	35	15	humoral	humoral	JJ
cord-027654-k0uby99n	35	16	and	and	CC
cord-027654-k0uby99n	35	17	cellular	cellular	JJ
cord-027654-k0uby99n	35	18	immunity	immunity	NN
cord-027654-k0uby99n	35	19	,	,	,
cord-027654-k0uby99n	35	20	thus	thus	RB
cord-027654-k0uby99n	35	21	providing	provide	VBG
cord-027654-k0uby99n	35	22	greater	great	JJR
cord-027654-k0uby99n	35	23	selective	selective	JJ
cord-027654-k0uby99n	35	24	pressure	pressure	NN
cord-027654-k0uby99n	35	25	on	on	IN
cord-027654-k0uby99n	35	26	infectious	infectious	JJ
cord-027654-k0uby99n	35	27	agents	agent	NNS
cord-027654-k0uby99n	35	28	in	in	IN
cord-027654-k0uby99n	35	29	vaccines	vaccine	NNS
cord-027654-k0uby99n	35	30	.	.	.
cord-027654-k0uby99n	36	1	In	in	IN
cord-027654-k0uby99n	36	2	this	this	DT
cord-027654-k0uby99n	36	3	chapter	chapter	NN
cord-027654-k0uby99n	36	4	,	,	,
cord-027654-k0uby99n	36	5	the	the	DT
cord-027654-k0uby99n	36	6	major	major	JJ
cord-027654-k0uby99n	36	7	genebased	genebase	VBN
cord-027654-k0uby99n	36	8	vaccines	vaccine	NNS
cord-027654-k0uby99n	36	9	progressing	progress	VBG
cord-027654-k0uby99n	36	10	into	into	IN
cord-027654-k0uby99n	36	11	clinical	clinical	JJ
cord-027654-k0uby99n	36	12	trials	trial	NNS
cord-027654-k0uby99n	36	13	are	be	VBP
cord-027654-k0uby99n	36	14	summarized	summarize	VBN
cord-027654-k0uby99n	36	15	,	,	,
cord-027654-k0uby99n	36	16	together	together	RB
cord-027654-k0uby99n	36	17	with	with	IN
cord-027654-k0uby99n	36	18	the	the	DT
cord-027654-k0uby99n	36	19	advantages	advantage	NNS
cord-027654-k0uby99n	36	20	and	and	CC
cord-027654-k0uby99n	36	21	disadvantages	disadvantage	NNS
cord-027654-k0uby99n	36	22	of	of	IN
cord-027654-k0uby99n	36	23	each	each	DT
cord-027654-k0uby99n	36	24	individual	individual	JJ
cord-027654-k0uby99n	36	25	vector	vector	NN
cord-027654-k0uby99n	36	26	and	and	CC
cord-027654-k0uby99n	36	27	their	-PRON-	PRP$
cord-027654-k0uby99n	36	28	infl	infl	NN
cord-027654-k0uby99n	36	29	uence	uence	NN
cord-027654-k0uby99n	36	30	on	on	IN
cord-027654-k0uby99n	36	31	different	different	JJ
cord-027654-k0uby99n	36	32	effector	effector	NN
cord-027654-k0uby99n	36	33	arms	arm	NNS
cord-027654-k0uby99n	36	34	of	of	IN
cord-027654-k0uby99n	36	35	the	the	DT
cord-027654-k0uby99n	36	36	immune	immune	JJ
cord-027654-k0uby99n	36	37	system	system	NN
cord-027654-k0uby99n	36	38	.	.	.
cord-027654-k0uby99n	37	1	While	while	IN
cord-027654-k0uby99n	37	2	there	there	EX
cord-027654-k0uby99n	37	3	is	be	VBZ
cord-027654-k0uby99n	37	4	considerable	considerable	JJ
cord-027654-k0uby99n	37	5	experience	experience	NN
cord-027654-k0uby99n	37	6	with	with	IN
cord-027654-k0uby99n	37	7	inactivated	inactivate	VBN
cord-027654-k0uby99n	37	8	viruses	virus	NNS
cord-027654-k0uby99n	37	9	and	and	CC
cord-027654-k0uby99n	37	10	protein	protein	NN
cord-027654-k0uby99n	37	11	-	-	HYPH
cord-027654-k0uby99n	37	12	based	base	VBN
cord-027654-k0uby99n	37	13	vaccines	vaccine	NNS
cord-027654-k0uby99n	37	14	,	,	,
cord-027654-k0uby99n	37	15	the	the	DT
cord-027654-k0uby99n	37	16	development	development	NN
cord-027654-k0uby99n	37	17	of	of	IN
cord-027654-k0uby99n	37	18	gene	gene	NN
cord-027654-k0uby99n	37	19	-	-	HYPH
cord-027654-k0uby99n	37	20	based	base	VBN
cord-027654-k0uby99n	37	21	vaccine	vaccine	NN
cord-027654-k0uby99n	37	22	vectors	vector	NNS
cord-027654-k0uby99n	37	23	is	be	VBZ
cord-027654-k0uby99n	37	24	only	only	RB
cord-027654-k0uby99n	37	25	beginning	begin	VBG
cord-027654-k0uby99n	37	26	.	.	.
cord-027654-k0uby99n	38	1	The	the	DT
cord-027654-k0uby99n	38	2	advantages	advantage	NNS
cord-027654-k0uby99n	38	3	of	of	IN
cord-027654-k0uby99n	38	4	their	-PRON-	PRP$
cord-027654-k0uby99n	38	5	ability	ability	NN
cord-027654-k0uby99n	38	6	to	to	TO
cord-027654-k0uby99n	38	7	induce	induce	VB
cord-027654-k0uby99n	38	8	cellular	cellular	JJ
cord-027654-k0uby99n	38	9	immunity	immunity	NN
cord-027654-k0uby99n	38	10	,	,	,
cord-027654-k0uby99n	38	11	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	38	12	,	,	,
cord-027654-k0uby99n	38	13	safety	safety	NN
cord-027654-k0uby99n	38	14	,	,	,
cord-027654-k0uby99n	38	15	mode	mode	NN
cord-027654-k0uby99n	38	16	of	of	IN
cord-027654-k0uby99n	38	17	antigen	antigen	NN
cord-027654-k0uby99n	38	18	presentation	presentation	NN
cord-027654-k0uby99n	38	19	,	,	,
cord-027654-k0uby99n	38	20	and	and	CC
cord-027654-k0uby99n	38	21	other	other	JJ
cord-027654-k0uby99n	38	22	attractive	attractive	JJ
cord-027654-k0uby99n	38	23	features	feature	NNS
cord-027654-k0uby99n	38	24	are	be	VBP
cord-027654-k0uby99n	38	25	countered	counter	VBN
cord-027654-k0uby99n	38	26	by	by	IN
cord-027654-k0uby99n	38	27	limitations	limitation	NNS
cord-027654-k0uby99n	38	28	in	in	IN
cord-027654-k0uby99n	38	29	knowledge	knowledge	NN
cord-027654-k0uby99n	38	30	about	about	IN
cord-027654-k0uby99n	38	31	clinical	clinical	JJ
cord-027654-k0uby99n	38	32	effi	effi	NNP
cord-027654-k0uby99n	38	33	cacy	cacy	NN
cord-027654-k0uby99n	38	34	,	,	,
cord-027654-k0uby99n	38	35	production	production	NN
cord-027654-k0uby99n	38	36	methodologies	methodology	NNS
cord-027654-k0uby99n	38	37	,	,	,
cord-027654-k0uby99n	38	38	DNA	dna	NN
cord-027654-k0uby99n	38	39	vaccination	vaccination	NN
cord-027654-k0uby99n	38	40	as	as	IN
cord-027654-k0uby99n	38	41	the	the	DT
cord-027654-k0uby99n	38	42	initial	initial	JJ
cord-027654-k0uby99n	38	43	vaccine	vaccine	NN
cord-027654-k0uby99n	38	44	constituent	constituent	NN
cord-027654-k0uby99n	38	45	and	and	CC
cord-027654-k0uby99n	38	46	replication	replication	NN
cord-027654-k0uby99n	38	47	-	-	HYPH
cord-027654-k0uby99n	38	48	defective	defective	JJ
cord-027654-k0uby99n	38	49	viral	viral	JJ
cord-027654-k0uby99n	38	50	vectors	vector	NNS
cord-027654-k0uby99n	38	51	,	,	,
cord-027654-k0uby99n	38	52	including	include	VBG
cord-027654-k0uby99n	38	53	modifi	modifi	NNP
cord-027654-k0uby99n	38	54	ed	ed	NNP
cord-027654-k0uby99n	38	55	vaccinia	vaccinia	NN
cord-027654-k0uby99n	38	56	Ankara	Ankara	NNP
cord-027654-k0uby99n	38	57	virus	virus	NN
cord-027654-k0uby99n	38	58	(	(	-LRB-
cord-027654-k0uby99n	38	59	MVA	MVA	NNP
cord-027654-k0uby99n	38	60	)	)	-RRB-
cord-027654-k0uby99n	38	61	,	,	,
cord-027654-k0uby99n	38	62	21,28	21,28	CD
cord-027654-k0uby99n	38	63	rAd	rAd	NNS
cord-027654-k0uby99n	38	64	22,23,27,29	22,23,27,29	CD
cord-027654-k0uby99n	38	65	or	or	CC
cord-027654-k0uby99n	38	66	proteins	protein	NNS
cord-027654-k0uby99n	38	67	to	to	TO
cord-027654-k0uby99n	38	68	boost	boost	VB
cord-027654-k0uby99n	38	69	the	the	DT
cord-027654-k0uby99n	38	70	initial	initial	JJ
cord-027654-k0uby99n	38	71	response	response	NN
cord-027654-k0uby99n	38	72	.	.	.
cord-027654-k0uby99n	39	1	This	this	DT
cord-027654-k0uby99n	39	2	approach	approach	NN
cord-027654-k0uby99n	39	3	avoids	avoid	VBZ
cord-027654-k0uby99n	39	4	repeat	repeat	VBP
cord-027654-k0uby99n	39	5	exposure	exposure	NN
cord-027654-k0uby99n	39	6	to	to	IN
cord-027654-k0uby99n	39	7	the	the	DT
cord-027654-k0uby99n	39	8	same	same	JJ
cord-027654-k0uby99n	39	9	viral	viral	JJ
cord-027654-k0uby99n	39	10	vector	vector	NN
cord-027654-k0uby99n	39	11	and	and	CC
cord-027654-k0uby99n	39	12	takes	take	VBZ
cord-027654-k0uby99n	39	13	advantage	advantage	NN
cord-027654-k0uby99n	39	14	of	of	IN
cord-027654-k0uby99n	39	15	the	the	DT
cord-027654-k0uby99n	39	16	ability	ability	NN
cord-027654-k0uby99n	39	17	of	of	IN
cord-027654-k0uby99n	39	18	DNA	dna	NN
cord-027654-k0uby99n	39	19	vaccines	vaccine	NNS
cord-027654-k0uby99n	39	20	to	to	TO
cord-027654-k0uby99n	39	21	evade	evade	VB
cord-027654-k0uby99n	39	22	anti	anti	JJ
cord-027654-k0uby99n	39	23	-	-	JJ
cord-027654-k0uby99n	39	24	vector	vector	JJ
cord-027654-k0uby99n	39	25	immunity	immunity	NN
cord-027654-k0uby99n	39	26	and	and	CC
cord-027654-k0uby99n	39	27	to	to	TO
cord-027654-k0uby99n	39	28	induce	induce	VB
cord-027654-k0uby99n	39	29	immune	immune	JJ
cord-027654-k0uby99n	39	30	responses	response	NNS
cord-027654-k0uby99n	39	31	to	to	IN
cord-027654-k0uby99n	39	32	subdominant	subdominant	JJ
cord-027654-k0uby99n	39	33	T	T	NNP
cord-027654-k0uby99n	39	34	cell	cell	NN
cord-027654-k0uby99n	39	35	epitopes	epitope	NNS
cord-027654-k0uby99n	39	36	that	that	WDT
cord-027654-k0uby99n	39	37	might	may	MD
cord-027654-k0uby99n	39	38	otherwise	otherwise	RB
cord-027654-k0uby99n	39	39	not	not	RB
cord-027654-k0uby99n	39	40	be	be	VB
cord-027654-k0uby99n	39	41	stimulated	stimulate	VBN
cord-027654-k0uby99n	39	42	.	.	.
cord-027654-k0uby99n	40	1	In	in	IN
cord-027654-k0uby99n	40	2	the	the	DT
cord-027654-k0uby99n	40	3	case	case	NN
cord-027654-k0uby99n	40	4	of	of	IN
cord-027654-k0uby99n	40	5	DNA	DNA	NNP
cord-027654-k0uby99n	40	6	/	/	SYM
cord-027654-k0uby99n	40	7	rAd	rAd	NNP
cord-027654-k0uby99n	40	8	prime	prime	JJ
cord-027654-k0uby99n	40	9	-	-	HYPH
cord-027654-k0uby99n	40	10	boost	boost	NN
cord-027654-k0uby99n	40	11	vaccination	vaccination	NN
cord-027654-k0uby99n	40	12	,	,	,
cord-027654-k0uby99n	40	13	this	this	DT
cord-027654-k0uby99n	40	14	vaccination	vaccination	NN
cord-027654-k0uby99n	40	15	approach	approach	NN
cord-027654-k0uby99n	40	16	induces	induce	VBZ
cord-027654-k0uby99n	40	17	greater	great	JJR
cord-027654-k0uby99n	40	18	breadth	breadth	NN
cord-027654-k0uby99n	40	19	of	of	IN
cord-027654-k0uby99n	40	20	the	the	DT
cord-027654-k0uby99n	40	21	CD4	CD4	NNP
cord-027654-k0uby99n	40	22	response	response	NN
cord-027654-k0uby99n	40	23	which	which	WDT
cord-027654-k0uby99n	40	24	in	in	IN
cord-027654-k0uby99n	40	25	turn	turn	NN
cord-027654-k0uby99n	40	26	supports	support	VBZ
cord-027654-k0uby99n	40	27	a	a	DT
cord-027654-k0uby99n	40	28	greater	great	JJR
cord-027654-k0uby99n	40	29	magnitude	magnitude	NN
cord-027654-k0uby99n	40	30	CD8	CD8	NNP
cord-027654-k0uby99n	40	31	response	response	NN
cord-027654-k0uby99n	40	32	that	that	WDT
cord-027654-k0uby99n	40	33	does	do	VBZ
cord-027654-k0uby99n	40	34	not	not	RB
cord-027654-k0uby99n	40	35	change	change	VB
cord-027654-k0uby99n	40	36	in	in	IN
cord-027654-k0uby99n	40	37	specifi	specifi	NN
cord-027654-k0uby99n	40	38	city	city	NN
cord-027654-k0uby99n	40	39	.	.	.
cord-027654-k0uby99n	41	1	30	30	CD
cord-027654-k0uby99n	42	1	There	there	EX
cord-027654-k0uby99n	42	2	is	be	VBZ
cord-027654-k0uby99n	42	3	one	one	CD
cord-027654-k0uby99n	42	4	Phase	Phase	NNP
cord-027654-k0uby99n	42	5	II	ii	CD
cord-027654-k0uby99n	42	6	study	study	NN
cord-027654-k0uby99n	42	7	with	with	IN
cord-027654-k0uby99n	42	8	a	a	DT
cord-027654-k0uby99n	42	9	DNA	dna	NN
cord-027654-k0uby99n	42	10	prime	prime	JJ
cord-027654-k0uby99n	42	11	-	-	HYPH
cord-027654-k0uby99n	42	12	rAd	rad	NN
cord-027654-k0uby99n	42	13	boost	boost	VB
cord-027654-k0uby99n	42	14	vaccine	vaccine	NN
cord-027654-k0uby99n	42	15	for	for	IN
cord-027654-k0uby99n	42	16	HIV	HIV	NNP
cord-027654-k0uby99n	42	17	infection	infection	NN
cord-027654-k0uby99n	42	18	that	that	WDT
cord-027654-k0uby99n	42	19	has	have	VBZ
cord-027654-k0uby99n	42	20	been	be	VBN
cord-027654-k0uby99n	42	21	conducted	conduct	VBN
cord-027654-k0uby99n	42	22	internationally	internationally	RB
cord-027654-k0uby99n	42	23	.	.	.
cord-027654-k0uby99n	43	1	A	a	DT
cord-027654-k0uby99n	43	2	potential	potential	JJ
cord-027654-k0uby99n	43	3	limitation	limitation	NN
cord-027654-k0uby99n	43	4	of	of	IN
cord-027654-k0uby99n	43	5	DNA	dna	NN
cord-027654-k0uby99n	43	6	vaccine	vaccine	NN
cord-027654-k0uby99n	43	7	technology	technology	NN
cord-027654-k0uby99n	43	8	is	be	VBZ
cord-027654-k0uby99n	43	9	its	-PRON-	PRP$
cord-027654-k0uby99n	43	10	low	low	JJ
cord-027654-k0uby99n	43	11	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	43	12	in	in	IN
cord-027654-k0uby99n	43	13	humans	human	NNS
cord-027654-k0uby99n	43	14	.	.	.
cord-027654-k0uby99n	44	1	Though	though	IN
cord-027654-k0uby99n	44	2	immune	immune	JJ
cord-027654-k0uby99n	44	3	responses	response	NNS
cord-027654-k0uby99n	44	4	can	can	MD
cord-027654-k0uby99n	44	5	be	be	VB
cord-027654-k0uby99n	44	6	induced	induce	VBN
cord-027654-k0uby99n	44	7	in	in	IN
cord-027654-k0uby99n	44	8	primates	primate	NNS
cord-027654-k0uby99n	44	9	,	,	,
cord-027654-k0uby99n	44	10	their	-PRON-	PRP$
cord-027654-k0uby99n	44	11	potency	potency	NN
cord-027654-k0uby99n	44	12	appears	appear	VBZ
cord-027654-k0uby99n	44	13	reduced	reduce	VBN
cord-027654-k0uby99n	44	14	relative	relative	JJ
cord-027654-k0uby99n	44	15	to	to	IN
cord-027654-k0uby99n	44	16	rodent	rodent	NN
cord-027654-k0uby99n	44	17	species	specie	NNS
cord-027654-k0uby99n	44	18	.	.	.
cord-027654-k0uby99n	45	1	In	in	IN
cord-027654-k0uby99n	45	2	part	part	NN
cord-027654-k0uby99n	45	3	,	,	,
cord-027654-k0uby99n	45	4	this	this	DT
cord-027654-k0uby99n	45	5	may	may	MD
cord-027654-k0uby99n	45	6	be	be	VB
cord-027654-k0uby99n	45	7	due	due	JJ
cord-027654-k0uby99n	45	8	to	to	IN
cord-027654-k0uby99n	45	9	the	the	DT
cord-027654-k0uby99n	45	10	relatively	relatively	RB
cord-027654-k0uby99n	45	11	lower	low	JJR
cord-027654-k0uby99n	45	12	dose	dose	NN
cord-027654-k0uby99n	45	13	of	of	IN
cord-027654-k0uby99n	45	14	DNA	dna	NN
cord-027654-k0uby99n	45	15	in	in	IN
cord-027654-k0uby99n	45	16	mass	mass	NN
cord-027654-k0uby99n	45	17	per	per	IN
cord-027654-k0uby99n	45	18	body	body	NN
cord-027654-k0uby99n	45	19	weight	weight	NN
cord-027654-k0uby99n	45	20	or	or	CC
cord-027654-k0uby99n	45	21	surface	surface	NN
cord-027654-k0uby99n	45	22	area	area	NN
cord-027654-k0uby99n	45	23	;	;	:
cord-027654-k0uby99n	45	24	however	however	RB
cord-027654-k0uby99n	45	25	,	,	,
cord-027654-k0uby99n	45	26	improvements	improvement	NNS
cord-027654-k0uby99n	45	27	in	in	IN
cord-027654-k0uby99n	45	28	expression	expression	NN
cord-027654-k0uby99n	45	29	vector	vector	NN
cord-027654-k0uby99n	45	30	technology	technology	NN
cord-027654-k0uby99n	45	31	and	and	CC
cord-027654-k0uby99n	45	32	in	in	IN
cord-027654-k0uby99n	45	33	the	the	DT
cord-027654-k0uby99n	45	34	development	development	NN
cord-027654-k0uby99n	45	35	of	of	IN
cord-027654-k0uby99n	45	36	DNA	dna	NN
cord-027654-k0uby99n	45	37	adjuvants	adjuvant	NNS
cord-027654-k0uby99n	45	38	offer	offer	VBP
cord-027654-k0uby99n	45	39	the	the	DT
cord-027654-k0uby99n	45	40	potential	potential	NN
cord-027654-k0uby99n	45	41	for	for	IN
cord-027654-k0uby99n	45	42	improvements	improvement	NNS
cord-027654-k0uby99n	45	43	in	in	IN
cord-027654-k0uby99n	45	44	this	this	DT
cord-027654-k0uby99n	45	45	area	area	NN
cord-027654-k0uby99n	46	1	(	(	-LRB-
cord-027654-k0uby99n	46	2	Fig	Fig	NNP
cord-027654-k0uby99n	46	3	.	.	.
cord-027654-k0uby99n	46	4	62	62	CD
cord-027654-k0uby99n	46	5	-	-	SYM
cord-027654-k0uby99n	46	6	1	1	CD
cord-027654-k0uby99n	46	7	)	)	-RRB-
cord-027654-k0uby99n	46	8	.	.	.
cord-027654-k0uby99n	47	1	One	one	CD
cord-027654-k0uby99n	47	2	successful	successful	JJ
cord-027654-k0uby99n	47	3	approach	approach	NN
cord-027654-k0uby99n	47	4	has	have	VBZ
cord-027654-k0uby99n	47	5	involved	involve	VBN
cord-027654-k0uby99n	47	6	improvement	improvement	NN
cord-027654-k0uby99n	47	7	of	of	IN
cord-027654-k0uby99n	47	8	transcriptional	transcriptional	JJ
cord-027654-k0uby99n	47	9	and	and	CC
cord-027654-k0uby99n	47	10	translational	translational	JJ
cord-027654-k0uby99n	47	11	effi	effi	NNP
cord-027654-k0uby99n	47	12	cacy	cacy	NNP
cord-027654-k0uby99n	47	13	using	use	VBG
cord-027654-k0uby99n	47	14	modifi	modifi	NNP
cord-027654-k0uby99n	47	15	ed	ed	NN
cord-027654-k0uby99n	47	16	codons	codon	NNS
cord-027654-k0uby99n	47	17	preferred	prefer	VBN
cord-027654-k0uby99n	47	18	in	in	IN
cord-027654-k0uby99n	47	19	the	the	DT
cord-027654-k0uby99n	47	20	host	host	NN
cord-027654-k0uby99n	47	21	species	specie	NNS
cord-027654-k0uby99n	47	22	.	.	.
cord-027654-k0uby99n	48	1	31	31	CD
cord-027654-k0uby99n	48	2	,	,	,
cord-027654-k0uby99n	48	3	32	32	CD
cord-027654-k0uby99n	49	1	In	in	IN
cord-027654-k0uby99n	49	2	addition	addition	NN
cord-027654-k0uby99n	49	3	,	,	,
cord-027654-k0uby99n	49	4	the	the	DT
cord-027654-k0uby99n	49	5	development	development	NN
cord-027654-k0uby99n	49	6	of	of	IN
cord-027654-k0uby99n	49	7	improved	improve	VBN
cord-027654-k0uby99n	49	8	enhancer/	enhancer/	NNP
cord-027654-k0uby99n	49	9	promoter	promoter	NN
cord-027654-k0uby99n	49	10	regions	region	NNS
cord-027654-k0uby99n	49	11	can	can	MD
cord-027654-k0uby99n	49	12	allow	allow	VB
cord-027654-k0uby99n	49	13	for	for	IN
cord-027654-k0uby99n	49	14	even	even	RB
cord-027654-k0uby99n	49	15	higher	high	JJR
cord-027654-k0uby99n	49	16	expression	expression	NN
cord-027654-k0uby99n	49	17	5	5	CD
cord-027654-k0uby99n	49	18	and	and	CC
cord-027654-k0uby99n	49	19	these	these	DT
cord-027654-k0uby99n	49	20	vaccines	vaccine	NNS
cord-027654-k0uby99n	49	21	have	have	VBP
cord-027654-k0uby99n	49	22	advanced	advance	VBN
cord-027654-k0uby99n	49	23	into	into	IN
cord-027654-k0uby99n	49	24	multiple	multiple	JJ
cord-027654-k0uby99n	49	25	human	human	JJ
cord-027654-k0uby99n	49	26	Phase	phase	NN
cord-027654-k0uby99n	49	27	I	-PRON-	PRP
cord-027654-k0uby99n	49	28	studies	study	NNS
cord-027654-k0uby99n	49	29	,	,	,
cord-027654-k0uby99n	49	30	alone	alone	RB
cord-027654-k0uby99n	49	31	or	or	CC
cord-027654-k0uby99n	49	32	in	in	IN
cord-027654-k0uby99n	49	33	combination	combination	NN
cord-027654-k0uby99n	49	34	with	with	IN
cord-027654-k0uby99n	49	35	other	other	JJ
cord-027654-k0uby99n	49	36	gene	gene	NN
cord-027654-k0uby99n	49	37	-	-	HYPH
cord-027654-k0uby99n	49	38	based	base	VBN
cord-027654-k0uby99n	49	39	vectors	vector	NNS
cord-027654-k0uby99n	49	40	.	.	.
cord-027654-k0uby99n	50	1	Advancements	advancement	NNS
cord-027654-k0uby99n	50	2	of	of	IN
cord-027654-k0uby99n	50	3	this	this	DT
cord-027654-k0uby99n	50	4	approach	approach	NN
cord-027654-k0uby99n	50	5	for	for	IN
cord-027654-k0uby99n	50	6	human	human	JJ
cord-027654-k0uby99n	50	7	use	use	NN
cord-027654-k0uby99n	50	8	will	will	MD
cord-027654-k0uby99n	50	9	require	require	VB
cord-027654-k0uby99n	50	10	further	further	JJ
cord-027654-k0uby99n	50	11	improvements	improvement	NNS
cord-027654-k0uby99n	50	12	,	,	,
cord-027654-k0uby99n	50	13	both	both	CC
cord-027654-k0uby99n	50	14	in	in	IN
cord-027654-k0uby99n	50	15	delivery	delivery	NN
cord-027654-k0uby99n	50	16	technology	technology	NN
cord-027654-k0uby99n	50	17	and	and	CC
cord-027654-k0uby99n	50	18	DNA	dna	NN
cord-027654-k0uby99n	50	19	adjuvants	adjuvant	NNS
cord-027654-k0uby99n	50	20	,	,	,
cord-027654-k0uby99n	50	21	of	of	IN
cord-027654-k0uby99n	50	22	which	which	WDT
cord-027654-k0uby99n	50	23	some	some	DT
cord-027654-k0uby99n	50	24	representative	representative	JJ
cord-027654-k0uby99n	50	25	approaches	approach	NNS
cord-027654-k0uby99n	50	26	are	be	VBP
cord-027654-k0uby99n	50	27	described	describe	VBN
cord-027654-k0uby99n	50	28	(	(	-LRB-
cord-027654-k0uby99n	50	29	Fig	Fig	NNP
cord-027654-k0uby99n	50	30	.	.	.
cord-027654-k0uby99n	50	31	62	62	CD
cord-027654-k0uby99n	50	32	-	-	SYM
cord-027654-k0uby99n	50	33	1	1	CD
cord-027654-k0uby99n	50	34	)	)	-RRB-
cord-027654-k0uby99n	50	35	.	.	.
cord-027654-k0uby99n	51	1	Advances	advance	NNS
cord-027654-k0uby99n	51	2	in	in	IN
cord-027654-k0uby99n	51	3	molecular	molecular	JJ
cord-027654-k0uby99n	51	4	virology	virology	NN
cord-027654-k0uby99n	51	5	have	have	VBP
cord-027654-k0uby99n	51	6	facilitated	facilitate	VBN
cord-027654-k0uby99n	51	7	an	an	DT
cord-027654-k0uby99n	51	8	understanding	understanding	NN
cord-027654-k0uby99n	51	9	of	of	IN
cord-027654-k0uby99n	51	10	the	the	DT
cord-027654-k0uby99n	51	11	regulation	regulation	NN
cord-027654-k0uby99n	51	12	of	of	IN
cord-027654-k0uby99n	51	13	viral	viral	JJ
cord-027654-k0uby99n	51	14	replication	replication	NN
cord-027654-k0uby99n	51	15	,	,	,
cord-027654-k0uby99n	51	16	gene	gene	NN
cord-027654-k0uby99n	51	17	expression	expression	NN
cord-027654-k0uby99n	51	18	,	,	,
cord-027654-k0uby99n	51	19	and	and	CC
cord-027654-k0uby99n	51	20	molecular	molecular	JJ
cord-027654-k0uby99n	51	21	pathogenesis	pathogenesis	NN
cord-027654-k0uby99n	51	22	.	.	.
cord-027654-k0uby99n	52	1	At	at	IN
cord-027654-k0uby99n	52	2	the	the	DT
cord-027654-k0uby99n	52	3	same	same	JJ
cord-027654-k0uby99n	52	4	time	time	NN
cord-027654-k0uby99n	52	5	,	,	,
cord-027654-k0uby99n	52	6	this	this	DT
cord-027654-k0uby99n	52	7	understanding	understanding	NN
cord-027654-k0uby99n	52	8	has	have	VBZ
cord-027654-k0uby99n	52	9	enabled	enable	VBN
cord-027654-k0uby99n	52	10	the	the	DT
cord-027654-k0uby99n	52	11	development	development	NN
cord-027654-k0uby99n	52	12	of	of	IN
cord-027654-k0uby99n	52	13	novel	novel	JJ
cord-027654-k0uby99n	52	14	viral	viral	JJ
cord-027654-k0uby99n	52	15	vectors	vector	NNS
cord-027654-k0uby99n	52	16	useful	useful	JJ
cord-027654-k0uby99n	52	17	for	for	IN
cord-027654-k0uby99n	52	18	vaccination	vaccination	NN
cord-027654-k0uby99n	52	19	.	.	.
cord-027654-k0uby99n	53	1	A	a	DT
cord-027654-k0uby99n	53	2	variety	variety	NN
cord-027654-k0uby99n	53	3	of	of	IN
cord-027654-k0uby99n	53	4	such	such	JJ
cord-027654-k0uby99n	53	5	vectors	vector	NNS
cord-027654-k0uby99n	53	6	have	have	VBP
cord-027654-k0uby99n	53	7	now	now	RB
cord-027654-k0uby99n	53	8	been	be	VBN
cord-027654-k0uby99n	53	9	advanced	advance	VBN
cord-027654-k0uby99n	53	10	in	in	IN
cord-027654-k0uby99n	53	11	preclinical	preclinical	JJ
cord-027654-k0uby99n	53	12	and	and	CC
cord-027654-k0uby99n	53	13	clinical	clinical	JJ
cord-027654-k0uby99n	53	14	studies	study	NNS
cord-027654-k0uby99n	53	15	(	(	-LRB-
cord-027654-k0uby99n	53	16	Fig	Fig	NNP
cord-027654-k0uby99n	53	17	.	.	.
cord-027654-k0uby99n	54	1	62	62	CD
cord-027654-k0uby99n	54	2	-	-	SYM
cord-027654-k0uby99n	54	3	1	1	CD
cord-027654-k0uby99n	54	4	)	)	-RRB-
cord-027654-k0uby99n	54	5	.	.	.
cord-027654-k0uby99n	55	1	Depending	depend	VBG
cord-027654-k0uby99n	55	2	on	on	IN
cord-027654-k0uby99n	55	3	their	-PRON-	PRP$
cord-027654-k0uby99n	55	4	ability	ability	NN
cord-027654-k0uby99n	55	5	to	to	TO
cord-027654-k0uby99n	55	6	target	target	VB
cord-027654-k0uby99n	55	7	antigen	antigen	NN
cord-027654-k0uby99n	55	8	presenting	present	VBG
cord-027654-k0uby99n	55	9	cells	cell	NNS
cord-027654-k0uby99n	55	10	,	,	,
cord-027654-k0uby99n	55	11	ability	ability	NN
cord-027654-k0uby99n	55	12	to	to	TO
cord-027654-k0uby99n	55	13	develop	develop	VB
cord-027654-k0uby99n	55	14	packaging	packaging	NN
cord-027654-k0uby99n	55	15	lines	line	NNS
cord-027654-k0uby99n	55	16	,	,	,
cord-027654-k0uby99n	55	17	inherent	inherent	JJ
cord-027654-k0uby99n	55	18	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	55	19	of	of	IN
cord-027654-k0uby99n	55	20	both	both	CC
cord-027654-k0uby99n	55	21	the	the	DT
cord-027654-k0uby99n	55	22	vector	vector	NN
cord-027654-k0uby99n	55	23	and	and	CC
cord-027654-k0uby99n	55	24	insert	insert	NN
cord-027654-k0uby99n	55	25	,	,	,
cord-027654-k0uby99n	55	26	and	and	CC
cord-027654-k0uby99n	55	27	other	other	JJ
cord-027654-k0uby99n	55	28	factors	factor	NNS
cord-027654-k0uby99n	55	29	(	(	-LRB-
cord-027654-k0uby99n	55	30	Table	table	NN
cord-027654-k0uby99n	55	31	62	62	CD
cord-027654-k0uby99n	55	32	-2	-2	CD
cord-027654-k0uby99n	55	33	)	)	-RRB-
cord-027654-k0uby99n	55	34	,	,	,
cord-027654-k0uby99n	55	35	these	these	DT
cord-027654-k0uby99n	55	36	viral	viral	JJ
cord-027654-k0uby99n	55	37	vectors	vector	NNS
cord-027654-k0uby99n	55	38	are	be	VBP
cord-027654-k0uby99n	55	39	helping	help	VBG
cord-027654-k0uby99n	55	40	to	to	TO
cord-027654-k0uby99n	55	41	improve	improve	VB
cord-027654-k0uby99n	55	42	vaccine	vaccine	NN
cord-027654-k0uby99n	55	43	effi	effi	NNP
cord-027654-k0uby99n	55	44	cacy	cacy	NN
cord-027654-k0uby99n	55	45	in	in	IN
cord-027654-k0uby99n	55	46	a	a	DT
cord-027654-k0uby99n	55	47	variety	variety	NN
cord-027654-k0uby99n	55	48	of	of	IN
cord-027654-k0uby99n	55	49	infectious	infectious	JJ
cord-027654-k0uby99n	55	50	disease	disease	NN
cord-027654-k0uby99n	55	51	models	model	NNS
cord-027654-k0uby99n	55	52	.	.	.
cord-027654-k0uby99n	56	1	The	the	DT
cord-027654-k0uby99n	56	2	properties	property	NNS
cord-027654-k0uby99n	56	3	of	of	IN
cord-027654-k0uby99n	56	4	the	the	DT
cord-027654-k0uby99n	56	5	more	more	RBR
cord-027654-k0uby99n	56	6	promising	promising	JJ
cord-027654-k0uby99n	56	7	vectors	vector	NNS
cord-027654-k0uby99n	56	8	and	and	CC
cord-027654-k0uby99n	56	9	current	current	JJ
cord-027654-k0uby99n	56	10	progress	progress	NN
cord-027654-k0uby99n	56	11	in	in	IN
cord-027654-k0uby99n	56	12	their	-PRON-	PRP$
cord-027654-k0uby99n	56	13	development	development	NN
cord-027654-k0uby99n	56	14	are	be	VBP
cord-027654-k0uby99n	56	15	summarized	summarize	VBN
cord-027654-k0uby99n	56	16	in	in	IN
cord-027654-k0uby99n	56	17	the	the	DT
cord-027654-k0uby99n	56	18	following	follow	VBG
cord-027654-k0uby99n	56	19	sections	section	NNS
cord-027654-k0uby99n	56	20	.	.	.
cord-027654-k0uby99n	57	1	Among	among	IN
cord-027654-k0uby99n	57	2	the	the	DT
cord-027654-k0uby99n	57	3	viral	viral	JJ
cord-027654-k0uby99n	57	4	vectors	vector	NNS
cord-027654-k0uby99n	57	5	that	that	WDT
cord-027654-k0uby99n	57	6	have	have	VBP
cord-027654-k0uby99n	57	7	shown	show	VBN
cord-027654-k0uby99n	57	8	promise	promise	NN
cord-027654-k0uby99n	57	9	for	for	IN
cord-027654-k0uby99n	57	10	their	-PRON-	PRP$
cord-027654-k0uby99n	57	11	ability	ability	NN
cord-027654-k0uby99n	57	12	to	to	TO
cord-027654-k0uby99n	57	13	elicit	elicit	VB
cord-027654-k0uby99n	57	14	protective	protective	JJ
cord-027654-k0uby99n	57	15	immunity	immunity	NN
cord-027654-k0uby99n	57	16	,	,	,
cord-027654-k0uby99n	57	17	recombinant	recombinant	JJ
cord-027654-k0uby99n	57	18	adenoviral	adenoviral	NNP
cord-027654-k0uby99n	57	19	vectors	vector	NNS
cord-027654-k0uby99n	57	20	(	(	-LRB-
cord-027654-k0uby99n	57	21	rAd	rAd	NNP
cord-027654-k0uby99n	57	22	)	)	-RRB-
cord-027654-k0uby99n	57	23	have	have	VBP
cord-027654-k0uby99n	57	24	now	now	RB
cord-027654-k0uby99n	57	25	demonstrated	demonstrate	VBN
cord-027654-k0uby99n	57	26	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	57	27	and	and	CC
cord-027654-k0uby99n	57	28	protective	protective	JJ
cord-027654-k0uby99n	57	29	immunity	immunity	NN
cord-027654-k0uby99n	57	30	in	in	IN
cord-027654-k0uby99n	57	31	a	a	DT
cord-027654-k0uby99n	57	32	variety	variety	NN
cord-027654-k0uby99n	57	33	of	of	IN
cord-027654-k0uby99n	57	34	animal	animal	NN
cord-027654-k0uby99n	57	35	models	model	NNS
cord-027654-k0uby99n	57	36	.	.	.
cord-027654-k0uby99n	58	1	Similar	similar	JJ
cord-027654-k0uby99n	58	2	to	to	IN
cord-027654-k0uby99n	58	3	DNA	dna	NN
cord-027654-k0uby99n	58	4	vaccines	vaccine	NNS
cord-027654-k0uby99n	58	5	,	,	,
cord-027654-k0uby99n	58	6	these	these	DT
cord-027654-k0uby99n	58	7	vectors	vector	NNS
cord-027654-k0uby99n	58	8	transduce	transduce	VBP
cord-027654-k0uby99n	58	9	cells	cell	NNS
cord-027654-k0uby99n	58	10	which	which	WDT
cord-027654-k0uby99n	58	11	can	can	MD
cord-027654-k0uby99n	58	12	synthesize	synthesize	VB
cord-027654-k0uby99n	58	13	native	native	JJ
cord-027654-k0uby99n	58	14	gene	gene	NN
cord-027654-k0uby99n	58	15	products	product	NNS
cord-027654-k0uby99n	58	16	and	and	CC
cord-027654-k0uby99n	58	17	appear	appear	VBP
cord-027654-k0uby99n	58	18	to	to	TO
cord-027654-k0uby99n	58	19	be	be	VB
cord-027654-k0uby99n	58	20	quite	quite	RB
cord-027654-k0uby99n	58	21	potent	potent	JJ
cord-027654-k0uby99n	58	22	in	in	IN
cord-027654-k0uby99n	58	23	their	-PRON-	PRP$
cord-027654-k0uby99n	58	24	ability	ability	NN
cord-027654-k0uby99n	58	25	to	to	TO
cord-027654-k0uby99n	58	26	induce	induce	VB
cord-027654-k0uby99n	58	27	not	not	RB
cord-027654-k0uby99n	58	28	only	only	RB
cord-027654-k0uby99n	58	29	helper	helper	NN
cord-027654-k0uby99n	58	30	but	but	CC
cord-027654-k0uby99n	58	31	specifi	specifi	NN
cord-027654-k0uby99n	58	32	cally	cally	RB
cord-027654-k0uby99n	58	33	cytolytic	cytolytic	VBD
cord-027654-k0uby99n	58	34	T	T	NNP
cord-027654-k0uby99n	58	35	cell	cell	NN
cord-027654-k0uby99n	58	36	immunity	immunity	NN
cord-027654-k0uby99n	58	37	;	;	:
cord-027654-k0uby99n	58	38	from	from	IN
cord-027654-k0uby99n	58	39	45	45	CD
cord-027654-k0uby99n	58	40	-	-	SYM
cord-027654-k0uby99n	58	41	90	90	CD
cord-027654-k0uby99n	58	42	%	%	NN
cord-027654-k0uby99n	58	43	in	in	IN
cord-027654-k0uby99n	58	44	various	various	JJ
cord-027654-k0uby99n	58	45	human	human	JJ
cord-027654-k0uby99n	58	46	studies	study	NNS
cord-027654-k0uby99n	58	47	.	.	.
cord-027654-k0uby99n	59	1	The	the	DT
cord-027654-k0uby99n	59	2	majority	majority	NN
cord-027654-k0uby99n	59	3	of	of	IN
cord-027654-k0uby99n	59	4	clinical	clinical	JJ
cord-027654-k0uby99n	59	5	vectors	vector	NNS
cord-027654-k0uby99n	59	6	have	have	VBP
cord-027654-k0uby99n	59	7	been	be	VBN
cord-027654-k0uby99n	59	8	derived	derive	VBN
cord-027654-k0uby99n	59	9	from	from	IN
cord-027654-k0uby99n	59	10	adenovirus	adenovirus	NN
cord-027654-k0uby99n	59	11	serotype	serotype	NN
cord-027654-k0uby99n	59	12	5	5	CD
cord-027654-k0uby99n	59	13	(	(	-LRB-
cord-027654-k0uby99n	59	14	Ad5	Ad5	NNP
cord-027654-k0uby99n	59	15	)	)	-RRB-
cord-027654-k0uby99n	59	16	,	,	,
cord-027654-k0uby99n	59	17	although	although	IN
cord-027654-k0uby99n	59	18	there	there	EX
cord-027654-k0uby99n	59	19	are	be	VBP
cord-027654-k0uby99n	59	20	more	more	JJR
cord-027654-k0uby99n	59	21	than	than	IN
cord-027654-k0uby99n	59	22	51	51	CD
cord-027654-k0uby99n	59	23	known	know	VBN
cord-027654-k0uby99n	59	24	human	human	JJ
cord-027654-k0uby99n	59	25	serotypes	serotype	NNS
cord-027654-k0uby99n	59	26	in	in	IN
cord-027654-k0uby99n	59	27	six	six	CD
cord-027654-k0uby99n	59	28	subfamilies	subfamily	NNS
cord-027654-k0uby99n	59	29	(	(	-LRB-
cord-027654-k0uby99n	59	30	A	A	NNP
cord-027654-k0uby99n	59	31	-	-	HYPH
cord-027654-k0uby99n	59	32	F	F	NNP
cord-027654-k0uby99n	59	33	)	)	-RRB-
cord-027654-k0uby99n	59	34	.	.	.
cord-027654-k0uby99n	60	1	Ad5	Ad5	NNP
cord-027654-k0uby99n	60	2	is	be	VBZ
cord-027654-k0uby99n	60	3	derived	derive	VBN
cord-027654-k0uby99n	60	4	from	from	IN
cord-027654-k0uby99n	60	5	the	the	DT
cord-027654-k0uby99n	60	6	C	C	NNP
cord-027654-k0uby99n	60	7	subfamily	subfamily	NN
cord-027654-k0uby99n	60	8	and	and	CC
cord-027654-k0uby99n	60	9	is	be	VBZ
cord-027654-k0uby99n	60	10	the	the	DT
cord-027654-k0uby99n	60	11	most	most	RBS
cord-027654-k0uby99n	60	12	common	common	JJ
cord-027654-k0uby99n	60	13	and	and	CC
cord-027654-k0uby99n	60	14	best	best	RB
cord-027654-k0uby99n	60	15	-	-	HYPH
cord-027654-k0uby99n	60	16	studied	study	VBN
cord-027654-k0uby99n	60	17	serotype	serotype	NN
cord-027654-k0uby99n	60	18	;	;	:
cord-027654-k0uby99n	60	19	however	however	RB
cord-027654-k0uby99n	60	20	,	,	,
cord-027654-k0uby99n	60	21	the	the	DT
cord-027654-k0uby99n	60	22	relatively	relatively	RB
cord-027654-k0uby99n	60	23	high	high	JJ
cord-027654-k0uby99n	60	24	prevalence	prevalence	NN
cord-027654-k0uby99n	60	25	of	of	IN
cord-027654-k0uby99n	60	26	immunity	immunity	NN
cord-027654-k0uby99n	60	27	to	to	IN
cord-027654-k0uby99n	60	28	Ad5	ad5	CD
cord-027654-k0uby99n	60	29	in	in	IN
cord-027654-k0uby99n	60	30	human	human	JJ
cord-027654-k0uby99n	60	31	populations	population	NNS
cord-027654-k0uby99n	60	32	may	may	MD
cord-027654-k0uby99n	60	33	pose	pose	VB
cord-027654-k0uby99n	60	34	limitations	limitation	NNS
cord-027654-k0uby99n	60	35	to	to	IN
cord-027654-k0uby99n	60	36	the	the	DT
cord-027654-k0uby99n	60	37	use	use	NN
cord-027654-k0uby99n	60	38	of	of	IN
cord-027654-k0uby99n	60	39	these	these	DT
cord-027654-k0uby99n	60	40	vectors	vector	NNS
cord-027654-k0uby99n	60	41	.	.	.
cord-027654-k0uby99n	61	1	Pre	pre	JJ
cord-027654-k0uby99n	61	2	-	-	JJ
cord-027654-k0uby99n	61	3	existing	existing	JJ
cord-027654-k0uby99n	61	4	anti	anti	JJ
cord-027654-k0uby99n	61	5	-	-	JJ
cord-027654-k0uby99n	61	6	Ad5	ad5	JJ
cord-027654-k0uby99n	61	7	immunity	immunity	NN
cord-027654-k0uby99n	61	8	may	may	MD
cord-027654-k0uby99n	61	9	inhibit	inhibit	VB
cord-027654-k0uby99n	61	10	the	the	DT
cord-027654-k0uby99n	61	11	response	response	NN
cord-027654-k0uby99n	61	12	to	to	IN
cord-027654-k0uby99n	61	13	rAd5	rad5	PRP$
cord-027654-k0uby99n	61	14	vaccine	vaccine	NN
cord-027654-k0uby99n	61	15	immunization	immunization	NN
cord-027654-k0uby99n	61	16	.	.	.
cord-027654-k0uby99n	62	1	For	for	IN
cord-027654-k0uby99n	62	2	this	this	DT
cord-027654-k0uby99n	62	3	reason	reason	NN
cord-027654-k0uby99n	62	4	,	,	,
cord-027654-k0uby99n	62	5	alternative	alternative	JJ
cord-027654-k0uby99n	62	6	serotypes	serotype	NNS
cord-027654-k0uby99n	62	7	and	and	CC
cord-027654-k0uby99n	62	8	chimeric	chimeric	JJ
cord-027654-k0uby99n	62	9	vectors	vector	NNS
cord-027654-k0uby99n	62	10	have	have	VBP
cord-027654-k0uby99n	62	11	been	be	VBN
cord-027654-k0uby99n	62	12	developed	develop	VBN
cord-027654-k0uby99n	62	13	to	to	TO
cord-027654-k0uby99n	62	14	circumvent	circumvent	VB
cord-027654-k0uby99n	62	15	this	this	DT
cord-027654-k0uby99n	62	16	potential	potential	JJ
cord-027654-k0uby99n	62	17	limitation	limitation	NN
cord-027654-k0uby99n	62	18	.	.	.
cord-027654-k0uby99n	63	1	The	the	DT
cord-027654-k0uby99n	63	2	attraction	attraction	NN
cord-027654-k0uby99n	63	3	to	to	IN
cord-027654-k0uby99n	63	4	rAd5	rad5	VB
cord-027654-k0uby99n	63	5	for	for	IN
cord-027654-k0uby99n	63	6	immunization	immunization	NN
cord-027654-k0uby99n	63	7	has	have	VBZ
cord-027654-k0uby99n	63	8	followed	follow	VBN
cord-027654-k0uby99n	63	9	from	from	IN
cord-027654-k0uby99n	63	10	its	-PRON-	PRP$
cord-027654-k0uby99n	63	11	success	success	NN
cord-027654-k0uby99n	63	12	with	with	IN
cord-027654-k0uby99n	63	13	a	a	DT
cord-027654-k0uby99n	63	14	variety	variety	NN
cord-027654-k0uby99n	63	15	of	of	IN
cord-027654-k0uby99n	63	16	preclinical	preclinical	JJ
cord-027654-k0uby99n	63	17	animal	animal	NN
cord-027654-k0uby99n	63	18	models	model	NNS
cord-027654-k0uby99n	63	19	and	and	CC
cord-027654-k0uby99n	63	20	Phase	Phase	NNP
cord-027654-k0uby99n	63	21	I	I	NNP
cord-027654-k0uby99n	63	22	/	/	SYM
cord-027654-k0uby99n	63	23	II	II	NNP
cord-027654-k0uby99n	63	24	human	human	JJ
cord-027654-k0uby99n	63	25	trials	trial	NNS
cord-027654-k0uby99n	63	26	.	.	.
cord-027654-k0uby99n	64	1	With	with	IN
cord-027654-k0uby99n	64	2	respect	respect	NN
cord-027654-k0uby99n	64	3	to	to	IN
cord-027654-k0uby99n	64	4	animal	animal	NN
cord-027654-k0uby99n	64	5	models	model	NNS
cord-027654-k0uby99n	64	6	,	,	,
cord-027654-k0uby99n	64	7	the	the	DT
cord-027654-k0uby99n	64	8	replication	replication	NN
cord-027654-k0uby99n	64	9	-	-	HYPH
cord-027654-k0uby99n	64	10	defective	defective	JJ
cord-027654-k0uby99n	64	11	adenovirus	adenovirus	NN
cord-027654-k0uby99n	64	12	has	have	VBZ
cord-027654-k0uby99n	64	13	been	be	VBN
cord-027654-k0uby99n	64	14	shown	show	VBN
cord-027654-k0uby99n	64	15	to	to	TO
cord-027654-k0uby99n	64	16	elicit	elicit	VB
cord-027654-k0uby99n	64	17	potent	potent	JJ
cord-027654-k0uby99n	64	18	immune	immune	JJ
cord-027654-k0uby99n	64	19	responses	response	NNS
cord-027654-k0uby99n	64	20	and	and	CC
cord-027654-k0uby99n	64	21	protection	protection	NN
cord-027654-k0uby99n	64	22	against	against	IN
cord-027654-k0uby99n	64	23	Ebola	Ebola	NNP
cord-027654-k0uby99n	64	24	virus	virus	NN
cord-027654-k0uby99n	64	25	,	,	,
cord-027654-k0uby99n	64	26	either	either	CC
cord-027654-k0uby99n	64	27	administered	administer	VBN
cord-027654-k0uby99n	64	28	alone	alone	RB
cord-027654-k0uby99n	64	29	as	as	IN
cord-027654-k0uby99n	64	30	a	a	DT
cord-027654-k0uby99n	64	31	single	single	JJ
cord-027654-k0uby99n	64	32	injection	injection	NN
cord-027654-k0uby99n	64	33	or	or	CC
cord-027654-k0uby99n	64	34	in	in	IN
cord-027654-k0uby99n	64	35	prime	prime	JJ
cord-027654-k0uby99n	64	36	-	-	HYPH
cord-027654-k0uby99n	64	37	boost	boost	NN
cord-027654-k0uby99n	64	38	combinations	combination	NNS
cord-027654-k0uby99n	64	39	.	.	.
cord-027654-k0uby99n	65	1	29,33	29,33	CD
cord-027654-k0uby99n	65	2	It	-PRON-	PRP
cord-027654-k0uby99n	65	3	is	be	VBZ
cord-027654-k0uby99n	65	4	interesting	interesting	JJ
cord-027654-k0uby99n	65	5	to	to	TO
cord-027654-k0uby99n	65	6	note	note	VB
cord-027654-k0uby99n	65	7	that	that	IN
cord-027654-k0uby99n	65	8	the	the	DT
cord-027654-k0uby99n	65	9	prime	prime	JJ
cord-027654-k0uby99n	65	10	-	-	HYPH
cord-027654-k0uby99n	65	11	boost	boost	NN
cord-027654-k0uby99n	65	12	approach	approach	NN
cord-027654-k0uby99n	65	13	induces	induce	VBZ
cord-027654-k0uby99n	65	14	more	more	RBR
cord-027654-k0uby99n	65	15	potent	potent	JJ
cord-027654-k0uby99n	65	16	and	and	CC
cord-027654-k0uby99n	65	17	durable	durable	JJ
cord-027654-k0uby99n	65	18	immunity	immunity	NN
cord-027654-k0uby99n	65	19	suitable	suitable	JJ
cord-027654-k0uby99n	65	20	for	for	IN
cord-027654-k0uby99n	65	21	a	a	DT
cord-027654-k0uby99n	65	22	preventive	preventive	JJ
cord-027654-k0uby99n	65	23	vaccine	vaccine	NN
cord-027654-k0uby99n	65	24	,	,	,
cord-027654-k0uby99n	65	25	while	while	IN
cord-027654-k0uby99n	65	26	a	a	DT
cord-027654-k0uby99n	65	27	single	single	JJ
cord-027654-k0uby99n	65	28	rAd	rAd	NNP
cord-027654-k0uby99n	65	29	vaccination	vaccination	NN
cord-027654-k0uby99n	65	30	induces	induce	VBZ
cord-027654-k0uby99n	65	31	a	a	DT
cord-027654-k0uby99n	65	32	more	more	RBR
cord-027654-k0uby99n	65	33	rapid	rapid	JJ
cord-027654-k0uby99n	65	34	response	response	NN
cord-027654-k0uby99n	65	35	that	that	WDT
cord-027654-k0uby99n	65	36	is	be	VBZ
cord-027654-k0uby99n	65	37	suffi	suffi	NNP
cord-027654-k0uby99n	65	38	cient	cient	NNP
cord-027654-k0uby99n	65	39	for	for	IN
cord-027654-k0uby99n	65	40	protection	protection	NN
cord-027654-k0uby99n	65	41	(	(	-LRB-
cord-027654-k0uby99n	65	42	Fig	fig	NN
cord-027654-k0uby99n	65	43	.	.	.
cord-027654-k0uby99n	66	1	62	62	CD
cord-027654-k0uby99n	66	2	-	-	SYM
cord-027654-k0uby99n	66	3	2	2	CD
cord-027654-k0uby99n	66	4	)	)	-RRB-
cord-027654-k0uby99n	66	5	.	.	.
cord-027654-k0uby99n	67	1	This	this	DT
cord-027654-k0uby99n	67	2	latter	latter	JJ
cord-027654-k0uby99n	67	3	approach	approach	NN
cord-027654-k0uby99n	67	4	may	may	MD
cord-027654-k0uby99n	67	5	be	be	VB
cord-027654-k0uby99n	67	6	useful	useful	JJ
cord-027654-k0uby99n	67	7	in	in	IN
cord-027654-k0uby99n	67	8	containing	contain	VBG
cord-027654-k0uby99n	67	9	acute	acute	JJ
cord-027654-k0uby99n	67	10	outbreaks	outbreak	NNS
cord-027654-k0uby99n	67	11	of	of	IN
cord-027654-k0uby99n	67	12	Ebola	Ebola	NNP
cord-027654-k0uby99n	67	13	infection	infection	NN
cord-027654-k0uby99n	67	14	and	and	CC
cord-027654-k0uby99n	67	15	could	could	MD
cord-027654-k0uby99n	67	16	be	be	VB
cord-027654-k0uby99n	67	17	applicable	applicable	JJ
cord-027654-k0uby99n	67	18	to	to	IN
cord-027654-k0uby99n	67	19	other	other	JJ
cord-027654-k0uby99n	67	20	pathogens	pathogen	NNS
cord-027654-k0uby99n	67	21	.	.	.
cord-027654-k0uby99n	68	1	33	33	CD
cord-027654-k0uby99n	69	1	In	in	IN
cord-027654-k0uby99n	69	2	addition	addition	NN
cord-027654-k0uby99n	69	3	,	,	,
cord-027654-k0uby99n	69	4	both	both	DT
cord-027654-k0uby99n	69	5	recombinant	recombinant	JJ
cord-027654-k0uby99n	69	6	Ad5	ad5	CD
cord-027654-k0uby99n	69	7	vaccines	vaccine	NNS
cord-027654-k0uby99n	69	8	,	,	,
cord-027654-k0uby99n	69	9	as	as	RB
cord-027654-k0uby99n	69	10	well	well	RB
cord-027654-k0uby99n	69	11	as	as	IN
cord-027654-k0uby99n	69	12	DNA	dna	NN
cord-027654-k0uby99n	69	13	prime	prime	JJ
cord-027654-k0uby99n	69	14	/	/	SYM
cord-027654-k0uby99n	69	15	recombinant	recombinant	JJ
cord-027654-k0uby99n	69	16	Ad5	Ad5	NNP
cord-027654-k0uby99n	69	17	boost	boost	NN
cord-027654-k0uby99n	69	18	combinations	combination	NNS
cord-027654-k0uby99n	69	19	,	,	,
cord-027654-k0uby99n	69	20	have	have	VBP
cord-027654-k0uby99n	69	21	been	be	VBN
cord-027654-k0uby99n	69	22	shown	show	VBN
cord-027654-k0uby99n	69	23	to	to	TO
cord-027654-k0uby99n	69	24	confer	confer	VB
cord-027654-k0uby99n	69	25	partial	partial	JJ
cord-027654-k0uby99n	69	26	protection	protection	NN
cord-027654-k0uby99n	69	27	in	in	IN
cord-027654-k0uby99n	69	28	rhesus	rhesus	NN
cord-027654-k0uby99n	69	29	macaques	macaque	NNS
cord-027654-k0uby99n	69	30	against	against	IN
cord-027654-k0uby99n	69	31	multiple	multiple	JJ
cord-027654-k0uby99n	69	32	HIV	HIV	NNP
cord-027654-k0uby99n	69	33	isolates	isolate	NNS
cord-027654-k0uby99n	69	34	,	,	,
cord-027654-k0uby99n	69	35	including	include	VBG
cord-027654-k0uby99n	69	36	SHIV-89.6P	SHIV-89.6P	NNP
cord-027654-k0uby99n	69	37	,	,	,
cord-027654-k0uby99n	69	38	22,23	22,23	CD
cord-027654-k0uby99n	69	39	SIVmac239	SIVmac239	NNP
cord-027654-k0uby99n	69	40	25	25	CD
cord-027654-k0uby99n	69	41	and	and	CC
cord-027654-k0uby99n	69	42	SIVmac251	SIVmac251	NNP
cord-027654-k0uby99n	69	43	.	.	.
cord-027654-k0uby99n	70	1	24,26,27	24,26,27	CD
cord-027654-k0uby99n	70	2	Replication	replication	NN
cord-027654-k0uby99n	70	3	-	-	HYPH
cord-027654-k0uby99n	70	4	defective	defective	JJ
cord-027654-k0uby99n	70	5	adenovirus	adenovirus	NN
cord-027654-k0uby99n	70	6	has	have	VBZ
cord-027654-k0uby99n	70	7	also	also	RB
cord-027654-k0uby99n	70	8	been	be	VBN
cord-027654-k0uby99n	70	9	used	use	VBN
cord-027654-k0uby99n	70	10	in	in	IN
cord-027654-k0uby99n	70	11	a	a	DT
cord-027654-k0uby99n	70	12	variety	variety	NN
cord-027654-k0uby99n	70	13	of	of	IN
cord-027654-k0uby99n	70	14	additional	additional	JJ
cord-027654-k0uby99n	70	15	animal	animal	NN
cord-027654-k0uby99n	70	16	models	model	NNS
cord-027654-k0uby99n	70	17	of	of	IN
cord-027654-k0uby99n	70	18	infectious	infectious	JJ
cord-027654-k0uby99n	70	19	disease	disease	NN
cord-027654-k0uby99n	70	20	,	,	,
cord-027654-k0uby99n	70	21	including	include	VBG
cord-027654-k0uby99n	70	22	plague	plague	NN
cord-027654-k0uby99n	70	23	,	,	,
cord-027654-k0uby99n	70	24	anthrax	anthrax	NN
cord-027654-k0uby99n	70	25	,	,	,
cord-027654-k0uby99n	70	26	infl	infl	NNP
cord-027654-k0uby99n	70	27	uenza	uenza	NNP
cord-027654-k0uby99n	70	28	and	and	CC
cord-027654-k0uby99n	70	29	malaria	malaria	NN
cord-027654-k0uby99n	70	30	.	.	.
cord-027654-k0uby99n	71	1	34	34	CD
cord-027654-k0uby99n	72	1	Phase	phase	NN
cord-027654-k0uby99n	72	2	I	-PRON-	PRP
cord-027654-k0uby99n	72	3	and	and	CC
cord-027654-k0uby99n	72	4	II	II	NNP
cord-027654-k0uby99n	72	5	clinical	clinical	JJ
cord-027654-k0uby99n	72	6	studies	study	NNS
cord-027654-k0uby99n	72	7	with	with	IN
cord-027654-k0uby99n	72	8	replication	replication	NN
cord-027654-k0uby99n	72	9	-	-	HYPH
cord-027654-k0uby99n	72	10	defective	defective	JJ
cord-027654-k0uby99n	72	11	adenoviral	adenoviral	JJ
cord-027654-k0uby99n	72	12	vectors	vector	NNS
cord-027654-k0uby99n	72	13	for	for	IN
cord-027654-k0uby99n	72	14	HIV-1	HIV-1	NNP
cord-027654-k0uby99n	72	15	have	have	VBP
cord-027654-k0uby99n	72	16	undergone	undergo	VBN
cord-027654-k0uby99n	72	17	analysis	analysis	NN
cord-027654-k0uby99n	72	18	independently	independently	RB
cord-027654-k0uby99n	72	19	by	by	IN
cord-027654-k0uby99n	72	20	the	the	DT
cord-027654-k0uby99n	72	21	Merck	Merck	NNP
cord-027654-k0uby99n	72	22	research	research	NN
cord-027654-k0uby99n	72	23	laboratories	laboratory	NNS
cord-027654-k0uby99n	72	24	and	and	CC
cord-027654-k0uby99n	72	25	the	the	DT
cord-027654-k0uby99n	72	26	NIH	NIH	NNP
cord-027654-k0uby99n	72	27	Vaccine	Vaccine	NNP
cord-027654-k0uby99n	72	28	Research	Research	NNP
cord-027654-k0uby99n	72	29	Center	Center	NNP
cord-027654-k0uby99n	72	30	in	in	IN
cord-027654-k0uby99n	72	31	NIAID	NIAID	NNP
cord-027654-k0uby99n	72	32	.	.	.
cord-027654-k0uby99n	73	1	The	the	DT
cord-027654-k0uby99n	73	2	clinical	clinical	JJ
cord-027654-k0uby99n	73	3	utility	utility	NN
cord-027654-k0uby99n	73	4	of	of	IN
cord-027654-k0uby99n	73	5	these	these	DT
cord-027654-k0uby99n	73	6	vaccines	vaccine	NNS
cord-027654-k0uby99n	73	7	has	have	VBZ
cord-027654-k0uby99n	73	8	yet	yet	RB
cord-027654-k0uby99n	73	9	to	to	TO
cord-027654-k0uby99n	73	10	be	be	VB
cord-027654-k0uby99n	73	11	defi	defi	NNP
cord-027654-k0uby99n	73	12	ned	ned	NNP
cord-027654-k0uby99n	73	13	;	;	:
cord-027654-k0uby99n	73	14	however	however	RB
cord-027654-k0uby99n	73	15	,	,	,
cord-027654-k0uby99n	73	16	the	the	DT
cord-027654-k0uby99n	73	17	preliminary	preliminary	JJ
cord-027654-k0uby99n	73	18	data	datum	NNS
cord-027654-k0uby99n	73	19	suggest	suggest	VBP
cord-027654-k0uby99n	73	20	that	that	IN
cord-027654-k0uby99n	73	21	rAd5	rad5	PRP$
cord-027654-k0uby99n	73	22	vaccines	vaccine	NNS
cord-027654-k0uby99n	73	23	elicit	elicit	VBP
cord-027654-k0uby99n	73	24	potent	potent	JJ
cord-027654-k0uby99n	73	25	cellular	cellular	JJ
cord-027654-k0uby99n	73	26	immune	immune	JJ
cord-027654-k0uby99n	73	27	responses	response	NNS
cord-027654-k0uby99n	73	28	in	in	IN
cord-027654-k0uby99n	73	29	humans	human	NNS
cord-027654-k0uby99n	73	30	.	.	.
cord-027654-k0uby99n	74	1	25	25	CD
cord-027654-k0uby99n	75	1	In	in	IN
cord-027654-k0uby99n	75	2	addition	addition	NN
cord-027654-k0uby99n	75	3	,	,	,
cord-027654-k0uby99n	75	4	the	the	DT
cord-027654-k0uby99n	75	5	DNA	dna	NN
cord-027654-k0uby99n	75	6	prime	prime	NN
cord-027654-k0uby99n	75	7	-	-	:
cord-027654-k0uby99n	75	8	rAd5	rad5	JJ
cord-027654-k0uby99n	75	9	boost	boost	NN
cord-027654-k0uby99n	75	10	combinations	combination	NNS
cord-027654-k0uby99n	75	11	appear	appear	VBP
cord-027654-k0uby99n	75	12	to	to	TO
cord-027654-k0uby99n	75	13	promote	promote	VB
cord-027654-k0uby99n	75	14	even	even	RB
cord-027654-k0uby99n	75	15	further	further	JJ
cord-027654-k0uby99n	75	16	stimulation	stimulation	NN
cord-027654-k0uby99n	75	17	,	,	,
cord-027654-k0uby99n	75	18	which	which	WDT
cord-027654-k0uby99n	75	19	has	have	VBZ
cord-027654-k0uby99n	75	20	proven	prove	VBN
cord-027654-k0uby99n	75	21	more	more	RBR
cord-027654-k0uby99n	75	22	effi	effi	JJ
cord-027654-k0uby99n	75	23	cacious	cacious	NN
cord-027654-k0uby99n	75	24	in	in	IN
cord-027654-k0uby99n	75	25	animal	animal	NN
cord-027654-k0uby99n	75	26	models	model	NNS
cord-027654-k0uby99n	75	27	of	of	IN
cord-027654-k0uby99n	75	28	SIV	SIV	NNP
cord-027654-k0uby99n	75	29	challenge	challenge	NN
cord-027654-k0uby99n	75	30	.	.	.
cord-027654-k0uby99n	76	1	A	a	DT
cord-027654-k0uby99n	76	2	more	more	RBR
cord-027654-k0uby99n	76	3	comprehensive	comprehensive	JJ
cord-027654-k0uby99n	76	4	Phase	Phase	NNP
cord-027654-k0uby99n	76	5	IIB	IIB	NNP
cord-027654-k0uby99n	76	6	clinical	clinical	JJ
cord-027654-k0uby99n	76	7	trial	trial	NN
cord-027654-k0uby99n	76	8	has	have	VBZ
cord-027654-k0uby99n	76	9	begun	begin	VBN
cord-027654-k0uby99n	76	10	and	and	CC
cord-027654-k0uby99n	76	11	should	should	MD
cord-027654-k0uby99n	76	12	provide	provide	VB
cord-027654-k0uby99n	76	13	information	information	NN
cord-027654-k0uby99n	76	14	regarding	regard	VBG
cord-027654-k0uby99n	76	15	potential	potential	JJ
cord-027654-k0uby99n	76	16	effi	effi	NNP
cord-027654-k0uby99n	76	17	cacy	cacy	NN
cord-027654-k0uby99n	76	18	of	of	IN
cord-027654-k0uby99n	76	19	the	the	DT
cord-027654-k0uby99n	76	20	Merck	Merck	NNP
cord-027654-k0uby99n	76	21	vaccine	vaccine	NN
cord-027654-k0uby99n	76	22	.	.	.
cord-027654-k0uby99n	77	1	In	in	IN
cord-027654-k0uby99n	77	2	addition	addition	NN
cord-027654-k0uby99n	77	3	,	,	,
cord-027654-k0uby99n	77	4	the	the	DT
cord-027654-k0uby99n	77	5	VRC	VRC	NNP
cord-027654-k0uby99n	77	6	DNA	DNA	NNP
cord-027654-k0uby99n	77	7	-	-	HYPH
cord-027654-k0uby99n	77	8	rAd5	rad5	JJ
cord-027654-k0uby99n	77	9	vaccine	vaccine	NN
cord-027654-k0uby99n	77	10	has	have	VBZ
cord-027654-k0uby99n	77	11	completed	complete	VBN
cord-027654-k0uby99n	77	12	Phase	Phase	NNP
cord-027654-k0uby99n	77	13	II	II	NNP
cord-027654-k0uby99n	77	14	testing	testing	NN
cord-027654-k0uby99n	77	15	and	and	CC
cord-027654-k0uby99n	77	16	may	may	MD
cord-027654-k0uby99n	77	17	undergo	undergo	VB
cord-027654-k0uby99n	77	18	effi	effi	NNP
cord-027654-k0uby99n	77	19	cacy	cacy	NNP
cord-027654-k0uby99n	77	20	testing	testing	NN
cord-027654-k0uby99n	77	21	in	in	IN
cord-027654-k0uby99n	77	22	the	the	DT
cord-027654-k0uby99n	77	23	near	near	JJ
cord-027654-k0uby99n	77	24	future	future	NN
cord-027654-k0uby99n	77	25	.	.	.
cord-027654-k0uby99n	78	1	The	the	DT
cord-027654-k0uby99n	78	2	effect	effect	NN
cord-027654-k0uby99n	78	3	of	of	IN
cord-027654-k0uby99n	78	4	pre	pre	JJ
cord-027654-k0uby99n	78	5	-	-	JJ
cord-027654-k0uby99n	78	6	existing	exist	VBG
cord-027654-k0uby99n	78	7	antivector	antivector	NN
cord-027654-k0uby99n	78	8	immunity	immunity	NN
cord-027654-k0uby99n	78	9	and	and	CC
cord-027654-k0uby99n	78	10	alternative	alternative	JJ
cord-027654-k0uby99n	78	11	adenovirus	adenovirus	NN
cord-027654-k0uby99n	78	12	serotypes	serotype	NNS
cord-027654-k0uby99n	78	13	Despite	despite	IN
cord-027654-k0uby99n	78	14	the	the	DT
cord-027654-k0uby99n	78	15	ability	ability	NN
cord-027654-k0uby99n	78	16	of	of	IN
cord-027654-k0uby99n	78	17	rAd5	rad5	VB
cord-027654-k0uby99n	78	18	to	to	TO
cord-027654-k0uby99n	78	19	induce	induce	VB
cord-027654-k0uby99n	78	20	potent	potent	JJ
cord-027654-k0uby99n	78	21	and	and	CC
cord-027654-k0uby99n	78	22	sustained	sustained	JJ
cord-027654-k0uby99n	78	23	immune	immune	JJ
cord-027654-k0uby99n	78	24	responses	response	NNS
cord-027654-k0uby99n	78	25	against	against	IN
cord-027654-k0uby99n	78	26	a	a	DT
cord-027654-k0uby99n	78	27	variety	variety	NN
cord-027654-k0uby99n	78	28	of	of	IN
cord-027654-k0uby99n	78	29	infectious	infectious	JJ
cord-027654-k0uby99n	78	30	pathogens	pathogen	NNS
cord-027654-k0uby99n	78	31	,	,	,
cord-027654-k0uby99n	78	32	concerns	concern	NNS
cord-027654-k0uby99n	78	33	remain	remain	VBP
cord-027654-k0uby99n	78	34	that	that	IN
cord-027654-k0uby99n	78	35	preexisting	preexist	VBG
cord-027654-k0uby99n	78	36	immunity	immunity	NN
cord-027654-k0uby99n	78	37	against	against	IN
cord-027654-k0uby99n	78	38	rAd5	rAd5	``
cord-027654-k0uby99n	78	39	may	may	MD
cord-027654-k0uby99n	78	40	compromise	compromise	VB
cord-027654-k0uby99n	78	41	its	-PRON-	PRP$
cord-027654-k0uby99n	78	42	effi	effi	NNP
cord-027654-k0uby99n	78	43	cacy	cacy	NNP
cord-027654-k0uby99n	78	44	.	.	.
cord-027654-k0uby99n	79	1	This	this	DT
cord-027654-k0uby99n	79	2	immunity	immunity	NN
cord-027654-k0uby99n	79	3	has	have	VBZ
cord-027654-k0uby99n	79	4	been	be	VBN
cord-027654-k0uby99n	79	5	found	find	VBN
cord-027654-k0uby99n	79	6	in	in	IN
cord-027654-k0uby99n	79	7	particular	particular	JJ
cord-027654-k0uby99n	79	8	in	in	IN
cord-027654-k0uby99n	79	9	certain	certain	JJ
cord-027654-k0uby99n	79	10	regions	region	NNS
cord-027654-k0uby99n	79	11	of	of	IN
cord-027654-k0uby99n	79	12	Africa	Africa	NNP
cord-027654-k0uby99n	79	13	,	,	,
cord-027654-k0uby99n	79	14	where	where	WRB
cord-027654-k0uby99n	79	15	Ad5	Ad5	NNP
cord-027654-k0uby99n	79	16	seroprevalence	seroprevalence	NN
cord-027654-k0uby99n	79	17	is	be	VBZ
cord-027654-k0uby99n	79	18	greater	great	JJR
cord-027654-k0uby99n	79	19	than	than	IN
cord-027654-k0uby99n	79	20	90	90	CD
cord-027654-k0uby99n	79	21	%	%	NN
cord-027654-k0uby99n	79	22	with	with	IN
cord-027654-k0uby99n	79	23	a	a	DT
cord-027654-k0uby99n	79	24	high	high	JJ
cord-027654-k0uby99n	79	25	degree	degree	NN
cord-027654-k0uby99n	79	26	of	of	IN
cord-027654-k0uby99n	79	27	neutralizing	neutralize	VBG
cord-027654-k0uby99n	79	28	antibody	antibody	NN
cord-027654-k0uby99n	79	29	.	.	.
cord-027654-k0uby99n	80	1	While	while	IN
cord-027654-k0uby99n	80	2	both	both	DT
cord-027654-k0uby99n	80	3	cellular	cellular	JJ
cord-027654-k0uby99n	80	4	and	and	CC
cord-027654-k0uby99n	80	5	humoral	humoral	JJ
cord-027654-k0uby99n	80	6	immune	immune	JJ
cord-027654-k0uby99n	80	7	responses	response	NNS
cord-027654-k0uby99n	80	8	contribute	contribute	VBP
cord-027654-k0uby99n	80	9	to	to	IN
cord-027654-k0uby99n	80	10	anti	anti	JJ
cord-027654-k0uby99n	80	11	-	-	JJ
cord-027654-k0uby99n	80	12	Ad5	ad5	JJ
cord-027654-k0uby99n	80	13	immunity	immunity	NN
cord-027654-k0uby99n	80	14	,	,	,
cord-027654-k0uby99n	80	15	it	-PRON-	PRP
cord-027654-k0uby99n	80	16	is	be	VBZ
cord-027654-k0uby99n	80	17	likely	likely	JJ
cord-027654-k0uby99n	80	18	that	that	IN
cord-027654-k0uby99n	80	19	the	the	DT
cord-027654-k0uby99n	80	20	Ad5	ad5	JJ
cord-027654-k0uby99n	80	21	neutralizing	neutralize	VBG
cord-027654-k0uby99n	80	22	antibodies	antibody	NNS
cord-027654-k0uby99n	80	23	play	play	VBP
cord-027654-k0uby99n	80	24	the	the	DT
cord-027654-k0uby99n	80	25	major	major	JJ
cord-027654-k0uby99n	80	26	role	role	NN
cord-027654-k0uby99n	80	27	in	in	IN
cord-027654-k0uby99n	80	28	suppressing	suppress	VBG
cord-027654-k0uby99n	80	29	rAd5-induced	rad5-induced	JJ
cord-027654-k0uby99n	80	30	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	80	31	,	,	,
cord-027654-k0uby99n	80	32	and	and	CC
cord-027654-k0uby99n	80	33	such	such	JJ
cord-027654-k0uby99n	80	34	immune	immune	JJ
cord-027654-k0uby99n	80	35	responses	response	NNS
cord-027654-k0uby99n	80	36	have	have	VBP
cord-027654-k0uby99n	80	37	been	be	VBN
cord-027654-k0uby99n	80	38	observed	observe	VBN
cord-027654-k0uby99n	80	39	in	in	IN
cord-027654-k0uby99n	80	40	humans	human	NNS
cord-027654-k0uby99n	80	41	.	.	.
cord-027654-k0uby99n	81	1	This	this	DT
cord-027654-k0uby99n	81	2	pre	pre	JJ
cord-027654-k0uby99n	81	3	-	-	JJ
cord-027654-k0uby99n	81	4	existing	existing	JJ
cord-027654-k0uby99n	81	5	immunity	immunity	NN
cord-027654-k0uby99n	81	6	can	can	MD
cord-027654-k0uby99n	81	7	reduce	reduce	VB
cord-027654-k0uby99n	81	8	the	the	DT
cord-027654-k0uby99n	81	9	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	81	10	of	of	IN
cord-027654-k0uby99n	81	11	Ad	ad	NN
cord-027654-k0uby99n	81	12	vaccines	vaccine	NNS
cord-027654-k0uby99n	81	13	in	in	IN
cord-027654-k0uby99n	81	14	mice	mouse	NNS
cord-027654-k0uby99n	81	15	,	,	,
cord-027654-k0uby99n	81	16	35	35	CD
cord-027654-k0uby99n	81	17	,	,	,
cord-027654-k0uby99n	81	18	36	36	CD
cord-027654-k0uby99n	81	19	rhesus	rhesu	NNS
cord-027654-k0uby99n	81	20	monkeys	monkey	NNS
cord-027654-k0uby99n	81	21	37	37	CD
cord-027654-k0uby99n	81	22	and	and	CC
cord-027654-k0uby99n	81	23	potentially	potentially	RB
cord-027654-k0uby99n	81	24	in	in	IN
cord-027654-k0uby99n	81	25	humans	human	NNS
cord-027654-k0uby99n	81	26	.	.	.
cord-027654-k0uby99n	82	1	38	38	CD
cord-027654-k0uby99n	82	2	,	,	,
cord-027654-k0uby99n	82	3	39	39	CD
cord-027654-k0uby99n	83	1	But	but	CC
cord-027654-k0uby99n	83	2	it	-PRON-	PRP
cord-027654-k0uby99n	83	3	is	be	VBZ
cord-027654-k0uby99n	83	4	not	not	RB
cord-027654-k0uby99n	83	5	clear	clear	JJ
cord-027654-k0uby99n	83	6	that	that	IN
cord-027654-k0uby99n	83	7	pre	pre	JJ
cord-027654-k0uby99n	83	8	-	-	JJ
cord-027654-k0uby99n	83	9	existing	existing	JJ
cord-027654-k0uby99n	83	10	immunity	immunity	NN
cord-027654-k0uby99n	83	11	in	in	IN
cord-027654-k0uby99n	83	12	humans	human	NNS
cord-027654-k0uby99n	83	13	will	will	MD
cord-027654-k0uby99n	83	14	block	block	VB
cord-027654-k0uby99n	83	15	vaccine	vaccine	NN
cord-027654-k0uby99n	83	16	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	83	17	.	.	.
cord-027654-k0uby99n	84	1	The	the	DT
cord-027654-k0uby99n	84	2	reduction	reduction	NN
cord-027654-k0uby99n	84	3	in	in	IN
cord-027654-k0uby99n	84	4	the	the	DT
cord-027654-k0uby99n	84	5	Gag	gag	NN
cord-027654-k0uby99n	84	6	-	-	HYPH
cord-027654-k0uby99n	84	7	specifi	specifi	NN
cord-027654-k0uby99n	84	8	c	c	NN
cord-027654-k0uby99n	84	9	response	response	NN
cord-027654-k0uby99n	84	10	induced	induce	VBN
cord-027654-k0uby99n	84	11	by	by	IN
cord-027654-k0uby99n	84	12	rAd5	rAd5	''
cord-027654-k0uby99n	84	13	in	in	IN
cord-027654-k0uby99n	84	14	Ad5	ad5	CD
cord-027654-k0uby99n	84	15	seropositive	seropositive	JJ
cord-027654-k0uby99n	84	16	recipients	recipient	NNS
cord-027654-k0uby99n	84	17	seen	see	VBN
cord-027654-k0uby99n	84	18	in	in	IN
cord-027654-k0uby99n	84	19	the	the	DT
cord-027654-k0uby99n	84	20	initial	initial	JJ
cord-027654-k0uby99n	84	21	Merck	Merck	NNP
cord-027654-k0uby99n	84	22	rAd5	rad5	PRP$
cord-027654-k0uby99n	84	23	HIV	HIV	NNP
cord-027654-k0uby99n	84	24	vaccine	vaccine	NN
cord-027654-k0uby99n	84	25	trial	trial	NN
cord-027654-k0uby99n	84	26	was	be	VBD
cord-027654-k0uby99n	84	27	less	less	RBR
cord-027654-k0uby99n	84	28	striking	striking	JJ
cord-027654-k0uby99n	84	29	when	when	WRB
cord-027654-k0uby99n	84	30	the	the	DT
cord-027654-k0uby99n	84	31	expression	expression	NN
cord-027654-k0uby99n	84	32	and	and	CC
cord-027654-k0uby99n	84	33	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	84	34	of	of	IN
cord-027654-k0uby99n	84	35	the	the	DT
cord-027654-k0uby99n	84	36	vector	vector	NN
cord-027654-k0uby99n	84	37	were	be	VBD
cord-027654-k0uby99n	84	38	improved	improve	VBN
cord-027654-k0uby99n	84	39	.	.	.
cord-027654-k0uby99n	85	1	Similarly	similarly	RB
cord-027654-k0uby99n	85	2	,	,	,
cord-027654-k0uby99n	85	3	in	in	IN
cord-027654-k0uby99n	85	4	VRC	VRC	NNP
cord-027654-k0uby99n	85	5	trials	trial	NNS
cord-027654-k0uby99n	85	6	of	of	IN
cord-027654-k0uby99n	85	7	DNA	dna	NN
cord-027654-k0uby99n	85	8	priming	priming	NN
cord-027654-k0uby99n	85	9	followed	follow	VBN
cord-027654-k0uby99n	85	10	by	by	IN
cord-027654-k0uby99n	85	11	rAd5	rad5	PRP$
cord-027654-k0uby99n	85	12	boosting	boost	VBG
cord-027654-k0uby99n	85	13	,	,	,
cord-027654-k0uby99n	85	14	signifi	signifi	NNP
cord-027654-k0uby99n	85	15	ca	can	MD
cord-027654-k0uby99n	85	16	nt	not	RB
cord-027654-k0uby99n	85	17	immune	immune	JJ
cord-027654-k0uby99n	85	18	responses	response	NNS
cord-027654-k0uby99n	85	19	are	be	VBP
cord-027654-k0uby99n	85	20	observed	observe	VBN
cord-027654-k0uby99n	85	21	in	in	IN
cord-027654-k0uby99n	85	22	rAd5	rad5	PRP$
cord-027654-k0uby99n	85	23	seropositive	seropositive	JJ
cord-027654-k0uby99n	85	24	individuals	individual	NNS
cord-027654-k0uby99n	85	25	.	.	.
cord-027654-k0uby99n	86	1	Several	several	JJ
cord-027654-k0uby99n	86	2	strategies	strategy	NNS
cord-027654-k0uby99n	86	3	have	have	VBP
cord-027654-k0uby99n	86	4	been	be	VBN
cord-027654-k0uby99n	86	5	developed	develop	VBN
cord-027654-k0uby99n	86	6	to	to	TO
cord-027654-k0uby99n	86	7	overcome	overcome	VB
cord-027654-k0uby99n	86	8	the	the	DT
cord-027654-k0uby99n	86	9	potential	potential	JJ
cord-027654-k0uby99n	86	10	problem	problem	NN
cord-027654-k0uby99n	86	11	of	of	IN
cord-027654-k0uby99n	86	12	rAd	rAd	NNP
cord-027654-k0uby99n	86	13	immunity	immunity	NN
cord-027654-k0uby99n	86	14	.	.	.
cord-027654-k0uby99n	87	1	Novel	novel	JJ
cord-027654-k0uby99n	87	2	methods	method	NNS
cord-027654-k0uby99n	87	3	to	to	TO
cord-027654-k0uby99n	87	4	deliver	deliver	VB
cord-027654-k0uby99n	87	5	existing	exist	VBG
cord-027654-k0uby99n	87	6	recombinant	recombinant	JJ
cord-027654-k0uby99n	87	7	Ad	ad	NN
cord-027654-k0uby99n	87	8	vectors	vector	NNS
cord-027654-k0uby99n	87	9	are	be	VBP
cord-027654-k0uby99n	87	10	being	be	VBG
cord-027654-k0uby99n	87	11	explored	explore	VBN
cord-027654-k0uby99n	87	12	.	.	.
cord-027654-k0uby99n	88	1	For	for	IN
cord-027654-k0uby99n	88	2	example	example	NN
cord-027654-k0uby99n	88	3	,	,	,
cord-027654-k0uby99n	88	4	it	-PRON-	PRP
cord-027654-k0uby99n	88	5	is	be	VBZ
cord-027654-k0uby99n	88	6	possible	possible	JJ
cord-027654-k0uby99n	88	7	that	that	IN
cord-027654-k0uby99n	88	8	the	the	DT
cord-027654-k0uby99n	88	9	administration	administration	NN
cord-027654-k0uby99n	88	10	of	of	IN
cord-027654-k0uby99n	88	11	higher	high	JJR
cord-027654-k0uby99n	88	12	doses	dose	NNS
cord-027654-k0uby99n	88	13	of	of	IN
cord-027654-k0uby99n	88	14	recombinant	recombinant	JJ
cord-027654-k0uby99n	88	15	Ad5	Ad5	NNP
cord-027654-k0uby99n	88	16	vectors	vector	NNS
cord-027654-k0uby99n	88	17	may	may	MD
cord-027654-k0uby99n	88	18	overcome	overcome	VB
cord-027654-k0uby99n	88	19	anti	anti	JJ
cord-027654-k0uby99n	88	20	-	-	JJ
cord-027654-k0uby99n	88	21	Ad5	ad5	JJ
cord-027654-k0uby99n	88	22	immunity	immunity	NN
cord-027654-k0uby99n	88	23	,	,	,
cord-027654-k0uby99n	88	24	although	although	IN
cord-027654-k0uby99n	88	25	this	this	DT
cord-027654-k0uby99n	88	26	strategy	strategy	NN
cord-027654-k0uby99n	88	27	may	may	MD
cord-027654-k0uby99n	88	28	be	be	VB
cord-027654-k0uby99n	88	29	limited	limit	VBN
cord-027654-k0uby99n	88	30	by	by	IN
cord-027654-k0uby99n	88	31	increased	increase	VBN
cord-027654-k0uby99n	88	32	toxicity	toxicity	NN
cord-027654-k0uby99n	88	33	with	with	IN
cord-027654-k0uby99n	88	34	dose	dose	JJ
cord-027654-k0uby99n	88	35	escalation	escalation	NN
cord-027654-k0uby99n	88	36	.	.	.
cord-027654-k0uby99n	89	1	Ad	ad	NN
cord-027654-k0uby99n	89	2	boosting	boosting	NN
cord-027654-k0uby99n	89	3	after	after	IN
cord-027654-k0uby99n	89	4	DNA	dna	NN
cord-027654-k0uby99n	89	5	priming	priming	NN
cord-027654-k0uby99n	89	6	may	may	MD
cord-027654-k0uby99n	89	7	potentially	potentially	RB
cord-027654-k0uby99n	89	8	overcome	overcome	VB
cord-027654-k0uby99n	89	9	its	-PRON-	PRP$
cord-027654-k0uby99n	89	10	immunosuppression	immunosuppression	NN
cord-027654-k0uby99n	89	11	,	,	,
cord-027654-k0uby99n	89	12	too	too	RB
cord-027654-k0uby99n	89	13	.	.	.
cord-027654-k0uby99n	90	1	35	35	CD
cord-027654-k0uby99n	90	2	,	,	,
cord-027654-k0uby99n	90	3	36	36	CD
cord-027654-k0uby99n	91	1	The	the	DT
cord-027654-k0uby99n	91	2	effi	effi	NNP
cord-027654-k0uby99n	91	3	cacy	cacy	NN
cord-027654-k0uby99n	91	4	of	of	IN
cord-027654-k0uby99n	91	5	this	this	DT
cord-027654-k0uby99n	91	6	approach	approach	NN
cord-027654-k0uby99n	91	7	in	in	IN
cord-027654-k0uby99n	91	8	humans	human	NNS
cord-027654-k0uby99n	91	9	remains	remain	VBZ
cord-027654-k0uby99n	91	10	to	to	TO
cord-027654-k0uby99n	91	11	be	be	VB
cord-027654-k0uby99n	91	12	determined	determine	VBN
cord-027654-k0uby99n	91	13	.	.	.
cord-027654-k0uby99n	92	1	Finally	finally	RB
cord-027654-k0uby99n	92	2	,	,	,
cord-027654-k0uby99n	92	3	the	the	DT
cord-027654-k0uby99n	92	4	administration	administration	NN
cord-027654-k0uby99n	92	5	of	of	IN
cord-027654-k0uby99n	92	6	Ad5	Ad5	NNP
cord-027654-k0uby99n	92	7	vectors	vector	NNS
cord-027654-k0uby99n	92	8	through	through	IN
cord-027654-k0uby99n	92	9	mucosal	mucosal	JJ
cord-027654-k0uby99n	92	10	routes	route	NNS
cord-027654-k0uby99n	92	11	may	may	MD
cord-027654-k0uby99n	92	12	help	help	VB
cord-027654-k0uby99n	92	13	to	to	TO
cord-027654-k0uby99n	92	14	circumvent	circumvent	VB
cord-027654-k0uby99n	92	15	this	this	DT
cord-027654-k0uby99n	92	16	problem	problem	NN
cord-027654-k0uby99n	92	17	.	.	.
cord-027654-k0uby99n	93	1	40	40	CD
cord-027654-k0uby99n	94	1	However	however	RB
cord-027654-k0uby99n	94	2	,	,	,
cord-027654-k0uby99n	94	3	the	the	DT
cord-027654-k0uby99n	94	4	safety	safety	NN
cord-027654-k0uby99n	94	5	of	of	IN
cord-027654-k0uby99n	94	6	this	this	DT
cord-027654-k0uby99n	94	7	approach	approach	NN
cord-027654-k0uby99n	94	8	,	,	,
cord-027654-k0uby99n	94	9	particularly	particularly	RB
cord-027654-k0uby99n	94	10	for	for	IN
cord-027654-k0uby99n	94	11	intranasal	intranasal	NN
cord-027654-k0uby99n	94	12	delivery	delivery	NN
cord-027654-k0uby99n	94	13	,	,	,
cord-027654-k0uby99n	94	14	has	have	VBZ
cord-027654-k0uby99n	94	15	yet	yet	RB
cord-027654-k0uby99n	94	16	to	to	TO
cord-027654-k0uby99n	94	17	be	be	VB
cord-027654-k0uby99n	94	18	determined	determine	VBN
cord-027654-k0uby99n	94	19	.	.	.
cord-027654-k0uby99n	95	1	41	41	CD
cord-027654-k0uby99n	96	1	In	in	IN
cord-027654-k0uby99n	96	2	addition	addition	NN
cord-027654-k0uby99n	96	3	,	,	,
cord-027654-k0uby99n	96	4	several	several	JJ
cord-027654-k0uby99n	96	5	investigators	investigator	NNS
cord-027654-k0uby99n	96	6	have	have	VBP
cord-027654-k0uby99n	96	7	explored	explore	VBN
cord-027654-k0uby99n	96	8	the	the	DT
cord-027654-k0uby99n	96	9	possibility	possibility	NN
cord-027654-k0uby99n	96	10	of	of	IN
cord-027654-k0uby99n	96	11	coating	coat	VBG
cord-027654-k0uby99n	96	12	rAd5	rad5	PRP$
cord-027654-k0uby99n	96	13	particles	particle	NNS
cord-027654-k0uby99n	96	14	with	with	IN
cord-027654-k0uby99n	96	15	chemicals	chemical	NNS
cord-027654-k0uby99n	96	16	such	such	JJ
cord-027654-k0uby99n	96	17	as	as	IN
cord-027654-k0uby99n	96	18	polyethylene	polyethylene	NN
cord-027654-k0uby99n	96	19	glycol	glycol	NN
cord-027654-k0uby99n	96	20	that	that	WDT
cord-027654-k0uby99n	96	21	may	may	MD
cord-027654-k0uby99n	96	22	block	block	VB
cord-027654-k0uby99n	96	23	access	access	NN
cord-027654-k0uby99n	96	24	of	of	IN
cord-027654-k0uby99n	96	25	antibodies	antibody	NNS
cord-027654-k0uby99n	96	26	to	to	IN
cord-027654-k0uby99n	96	27	the	the	DT
cord-027654-k0uby99n	96	28	viral	viral	JJ
cord-027654-k0uby99n	96	29	surface	surface	NN
cord-027654-k0uby99n	96	30	.	.	.
cord-027654-k0uby99n	97	1	41a	41a	.
cord-027654-k0uby99n	98	1	Alternative	alternative	JJ
cord-027654-k0uby99n	98	2	approaches	approach	NNS
cord-027654-k0uby99n	98	3	to	to	IN
cord-027654-k0uby99n	98	4	evasion	evasion	NN
cord-027654-k0uby99n	98	5	of	of	IN
cord-027654-k0uby99n	98	6	Ad5	ad5	CD
cord-027654-k0uby99n	98	7	immunity	immunity	NN
cord-027654-k0uby99n	98	8	include	include	VBP
cord-027654-k0uby99n	98	9	engineering	engineering	NN
cord-027654-k0uby99n	98	10	of	of	IN
cord-027654-k0uby99n	98	11	the	the	DT
cord-027654-k0uby99n	98	12	vectors	vector	NNS
cord-027654-k0uby99n	98	13	to	to	TO
cord-027654-k0uby99n	98	14	evade	evade	VB
cord-027654-k0uby99n	98	15	dominant	dominant	JJ
cord-027654-k0uby99n	98	16	Ad5	ad5	CD
cord-027654-k0uby99n	98	17	immune	immune	JJ
cord-027654-k0uby99n	98	18	responses	response	NNS
cord-027654-k0uby99n	98	19	.	.	.
cord-027654-k0uby99n	99	1	A	a	DT
cord-027654-k0uby99n	99	2	variety	variety	NN
cord-027654-k0uby99n	99	3	of	of	IN
cord-027654-k0uby99n	99	4	chimeric	chimeric	JJ
cord-027654-k0uby99n	99	5	fi	fi	NN
cord-027654-k0uby99n	99	6	ber	ber	NNP
cord-027654-k0uby99n	99	7	or	or	CC
cord-027654-k0uby99n	99	8	hexon	hexon	NNP
cord-027654-k0uby99n	99	9	proteins	protein	NNS
cord-027654-k0uby99n	99	10	have	have	VBP
cord-027654-k0uby99n	99	11	been	be	VBN
cord-027654-k0uby99n	99	12	described	describe	VBN
cord-027654-k0uby99n	99	13	that	that	WDT
cord-027654-k0uby99n	99	14	maintain	maintain	VBP
cord-027654-k0uby99n	99	15	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	99	16	and	and	CC
cord-027654-k0uby99n	99	17	can	can	MD
cord-027654-k0uby99n	99	18	evade	evade	VB
cord-027654-k0uby99n	99	19	neutralizing	neutralize	VBG
cord-027654-k0uby99n	99	20	antibodies	antibody	NNS
cord-027654-k0uby99n	99	21	,	,	,
cord-027654-k0uby99n	99	22	both	both	CC
cord-027654-k0uby99n	99	23	against	against	IN
cord-027654-k0uby99n	99	24	the	the	DT
cord-027654-k0uby99n	99	25	fi	fi	NNP
cord-027654-k0uby99n	99	26	ber	ber	NNP
cord-027654-k0uby99n	99	27	[	[	-LRB-
cord-027654-k0uby99n	99	28	42	42	CD
cord-027654-k0uby99n	99	29	]	]	-RRB-
cord-027654-k0uby99n	100	1	[	[	-LRB-
cord-027654-k0uby99n	100	2	43	43	CD
cord-027654-k0uby99n	100	3	]	]	-RRB-
cord-027654-k0uby99n	100	4	[	[	-LRB-
cord-027654-k0uby99n	100	5	44	44	CD
cord-027654-k0uby99n	100	6	]	]	-RRB-
cord-027654-k0uby99n	101	1	[	[	-LRB-
cord-027654-k0uby99n	101	2	45	45	CD
cord-027654-k0uby99n	101	3	]	]	-RRB-
cord-027654-k0uby99n	101	4	or	or	CC
cord-027654-k0uby99n	101	5	through	through	IN
cord-027654-k0uby99n	101	6	the	the	DT
cord-027654-k0uby99n	101	7	use	use	NN
cord-027654-k0uby99n	101	8	of	of	IN
cord-027654-k0uby99n	101	9	hexon	hexon	NNP
cord-027654-k0uby99n	101	10	chimeras	chimera	NNS
cord-027654-k0uby99n	101	11	which	which	WDT
cord-027654-k0uby99n	101	12	appear	appear	VBP
cord-027654-k0uby99n	101	13	to	to	TO
cord-027654-k0uby99n	101	14	be	be	VB
cord-027654-k0uby99n	101	15	the	the	DT
cord-027654-k0uby99n	101	16	targets	target	NNS
cord-027654-k0uby99n	101	17	of	of	IN
cord-027654-k0uby99n	101	18	the	the	DT
cord-027654-k0uby99n	101	19	major	major	JJ
cord-027654-k0uby99n	101	20	neutralizing	neutralize	VBG
cord-027654-k0uby99n	101	21	antibody	antibody	NN
cord-027654-k0uby99n	101	22	response	response	NN
cord-027654-k0uby99n	101	23	.	.	.
cord-027654-k0uby99n	102	1	46	46	CD
cord-027654-k0uby99n	102	2	,	,	,
cord-027654-k0uby99n	102	3	47	47	CD
cord-027654-k0uby99n	103	1	Another	another	DT
cord-027654-k0uby99n	103	2	approach	approach	NN
cord-027654-k0uby99n	103	3	to	to	IN
cord-027654-k0uby99n	103	4	antivector	antivector	NNP
cord-027654-k0uby99n	103	5	immunity	immunity	NN
cord-027654-k0uby99n	103	6	involves	involve	VBZ
cord-027654-k0uby99n	103	7	the	the	DT
cord-027654-k0uby99n	103	8	development	development	NN
cord-027654-k0uby99n	103	9	of	of	IN
cord-027654-k0uby99n	103	10	novel	novel	JJ
cord-027654-k0uby99n	103	11	vectors	vector	NNS
cord-027654-k0uby99n	103	12	from	from	IN
cord-027654-k0uby99n	103	13	alternative	alternative	JJ
cord-027654-k0uby99n	103	14	serotypes	serotype	NNS
cord-027654-k0uby99n	103	15	.	.	.
cord-027654-k0uby99n	104	1	To	to	TO
cord-027654-k0uby99n	104	2	develop	develop	VB
cord-027654-k0uby99n	104	3	such	such	JJ
cord-027654-k0uby99n	104	4	vectors	vector	NNS
cord-027654-k0uby99n	104	5	,	,	,
cord-027654-k0uby99n	104	6	investigators	investigator	NNS
cord-027654-k0uby99n	104	7	have	have	VBP
cord-027654-k0uby99n	104	8	evaluated	evaluate	VBN
cord-027654-k0uby99n	104	9	rAd	rAd	NNP
cord-027654-k0uby99n	104	10	vectors	vector	NNS
cord-027654-k0uby99n	104	11	from	from	IN
cord-027654-k0uby99n	104	12	low	low	JJ
cord-027654-k0uby99n	104	13	seroprevalence	seroprevalence	NN
cord-027654-k0uby99n	104	14	human	human	JJ
cord-027654-k0uby99n	104	15	adenoviruses	adenovirus	NNS
cord-027654-k0uby99n	104	16	,	,	,
cord-027654-k0uby99n	104	17	as	as	RB
cord-027654-k0uby99n	104	18	well	well	RB
cord-027654-k0uby99n	104	19	as	as	IN
cord-027654-k0uby99n	104	20	from	from	IN
cord-027654-k0uby99n	104	21	nonhuman	nonhuman	NN
cord-027654-k0uby99n	104	22	primates	primate	NNS
cord-027654-k0uby99n	104	23	.	.	.
cord-027654-k0uby99n	105	1	Recombinant	Recombinant	NNP
cord-027654-k0uby99n	105	2	Ad	Ad	NNP
cord-027654-k0uby99n	105	3	vectors	vector	NNS
cord-027654-k0uby99n	105	4	from	from	IN
cord-027654-k0uby99n	105	5	human	human	JJ
cord-027654-k0uby99n	105	6	serotypes	serotype	NNS
cord-027654-k0uby99n	105	7	have	have	VBP
cord-027654-k0uby99n	105	8	been	be	VBN
cord-027654-k0uby99n	105	9	well	well	RB
cord-027654-k0uby99n	105	10	described	describe	VBN
cord-027654-k0uby99n	105	11	.	.	.
cord-027654-k0uby99n	106	1	[	[	-LRB-
cord-027654-k0uby99n	106	2	48	48	CD
cord-027654-k0uby99n	106	3	]	]	-RRB-
cord-027654-k0uby99n	106	4	[	[	-LRB-
cord-027654-k0uby99n	106	5	49	49	CD
cord-027654-k0uby99n	106	6	]	]	-RRB-
cord-027654-k0uby99n	107	1	[	[	-LRB-
cord-027654-k0uby99n	107	2	50	50	CD
cord-027654-k0uby99n	107	3	]	]	-RRB-
cord-027654-k0uby99n	108	1	Seroprevalence	Seroprevalence	NNP
cord-027654-k0uby99n	108	2	of	of	IN
cord-027654-k0uby99n	108	3	the	the	DT
cord-027654-k0uby99n	108	4	51	51	CD
cord-027654-k0uby99n	108	5	Ad	ad	NN
cord-027654-k0uby99n	108	6	serotypes	serotype	NNS
cord-027654-k0uby99n	108	7	suggests	suggest	VBZ
cord-027654-k0uby99n	108	8	that	that	IN
cord-027654-k0uby99n	108	9	the	the	DT
cord-027654-k0uby99n	108	10	Ad11	Ad11	NNP
cord-027654-k0uby99n	108	11	and	and	CC
cord-027654-k0uby99n	108	12	Ad35	Ad35	NNP
cord-027654-k0uby99n	108	13	subfamilies	subfamily	NNS
cord-027654-k0uby99n	108	14	as	as	RB
cord-027654-k0uby99n	108	15	well	well	RB
cord-027654-k0uby99n	108	16	as	as	IN
cord-027654-k0uby99n	108	17	adenoviruses	adenovirus	NNS
cord-027654-k0uby99n	108	18	from	from	IN
cord-027654-k0uby99n	108	19	subfamily	subfamily	NN
cord-027654-k0uby99n	108	20	D	d	NN
cord-027654-k0uby99n	108	21	,	,	,
cord-027654-k0uby99n	108	22	including	include	VBG
cord-027654-k0uby99n	108	23	Ad26	Ad26	NNP
cord-027654-k0uby99n	108	24	,	,	,
cord-027654-k0uby99n	108	25	are	be	VBP
cord-027654-k0uby99n	108	26	uncommon	uncommon	JJ
cord-027654-k0uby99n	108	27	in	in	IN
cord-027654-k0uby99n	108	28	humans	human	NNS
cord-027654-k0uby99n	108	29	51	51	CD
cord-027654-k0uby99n	108	30	and	and	CC
cord-027654-k0uby99n	108	31	may	may	MD
cord-027654-k0uby99n	108	32	therefore	therefore	RB
cord-027654-k0uby99n	108	33	offer	offer	VB
cord-027654-k0uby99n	108	34	advantages	advantage	NNS
cord-027654-k0uby99n	108	35	over	over	IN
cord-027654-k0uby99n	108	36	Ad5	ad5	CD
cord-027654-k0uby99n	108	37	as	as	IN
cord-027654-k0uby99n	108	38	vectors	vector	NNS
cord-027654-k0uby99n	108	39	.	.	.
cord-027654-k0uby99n	109	1	Novel	novel	NN
cord-027654-k0uby99n	109	2	vectors	vector	NNS
cord-027654-k0uby99n	109	3	based	base	VBN
cord-027654-k0uby99n	109	4	on	on	IN
cord-027654-k0uby99n	109	5	rAd35	rad35	NN
cord-027654-k0uby99n	109	6	and	and	CC
cord-027654-k0uby99n	109	7	rAd11	rad11	RB
cord-027654-k0uby99n	109	8	have	have	VBP
cord-027654-k0uby99n	109	9	been	be	VBN
cord-027654-k0uby99n	109	10	developed	develop	VBN
cord-027654-k0uby99n	109	11	,	,	,
cord-027654-k0uby99n	109	12	and	and	CC
cord-027654-k0uby99n	109	13	preclinical	preclinical	JJ
cord-027654-k0uby99n	109	14	studies	study	NNS
cord-027654-k0uby99n	109	15	suggest	suggest	VBP
cord-027654-k0uby99n	109	16	that	that	IN
cord-027654-k0uby99n	109	17	they	-PRON-	PRP
cord-027654-k0uby99n	109	18	are	be	VBP
cord-027654-k0uby99n	109	19	resistant	resistant	JJ
cord-027654-k0uby99n	109	20	to	to	IN
cord-027654-k0uby99n	109	21	anti	anti	JJ
cord-027654-k0uby99n	109	22	-	-	JJ
cord-027654-k0uby99n	109	23	Ad5	ad5	JJ
cord-027654-k0uby99n	109	24	immunity	immunity	NN
cord-027654-k0uby99n	109	25	in	in	IN
cord-027654-k0uby99n	109	26	mice	mouse	NNS
cord-027654-k0uby99n	109	27	.	.	.
cord-027654-k0uby99n	110	1	52	52	CD
cord-027654-k0uby99n	111	1	,	,	,
cord-027654-k0uby99n	111	2	53	53	CD
cord-027654-k0uby99n	112	1	The	the	DT
cord-027654-k0uby99n	112	2	utility	utility	NN
cord-027654-k0uby99n	112	3	of	of	IN
cord-027654-k0uby99n	112	4	these	these	DT
cord-027654-k0uby99n	112	5	vectors	vector	NNS
cord-027654-k0uby99n	112	6	has	have	VBZ
cord-027654-k0uby99n	112	7	been	be	VBN
cord-027654-k0uby99n	112	8	compared	compare	VBN
cord-027654-k0uby99n	112	9	to	to	IN
cord-027654-k0uby99n	112	10	rAd5	rad5	ADD
cord-027654-k0uby99n	112	11	.	.	.
cord-027654-k0uby99n	113	1	While	while	IN
cord-027654-k0uby99n	113	2	some	some	DT
cord-027654-k0uby99n	113	3	of	of	IN
cord-027654-k0uby99n	113	4	the	the	DT
cord-027654-k0uby99n	113	5	alternative	alternative	JJ
cord-027654-k0uby99n	113	6	vectors	vector	NNS
cord-027654-k0uby99n	113	7	show	show	VBP
cord-027654-k0uby99n	113	8	less	less	JJR
cord-027654-k0uby99n	113	9	seropositivity	seropositivity	NN
cord-027654-k0uby99n	113	10	,	,	,
cord-027654-k0uby99n	113	11	they	-PRON-	PRP
cord-027654-k0uby99n	113	12	are	be	VBP
cord-027654-k0uby99n	113	13	often	often	RB
cord-027654-k0uby99n	113	14	also	also	RB
cord-027654-k0uby99n	113	15	less	less	RBR
cord-027654-k0uby99n	113	16	immunogenic	immunogenic	JJ
cord-027654-k0uby99n	113	17	in	in	IN
cord-027654-k0uby99n	113	18	preclinical	preclinical	JJ
cord-027654-k0uby99n	113	19	animal	animal	NN
cord-027654-k0uby99n	113	20	studies	study	NNS
cord-027654-k0uby99n	113	21	;	;	:
cord-027654-k0uby99n	113	22	how	how	WRB
cord-027654-k0uby99n	113	23	they	-PRON-	PRP
cord-027654-k0uby99n	113	24	are	be	VBP
cord-027654-k0uby99n	113	25	able	able	JJ
cord-027654-k0uby99n	113	26	to	to	TO
cord-027654-k0uby99n	113	27	perform	perform	VB
cord-027654-k0uby99n	113	28	in	in	IN
cord-027654-k0uby99n	113	29	human	human	JJ
cord-027654-k0uby99n	113	30	studies	study	NNS
cord-027654-k0uby99n	113	31	compared	compare	VBN
cord-027654-k0uby99n	113	32	to	to	IN
cord-027654-k0uby99n	113	33	Ad5	Ad5	NNP
cord-027654-k0uby99n	113	34	vectors	vector	NNS
cord-027654-k0uby99n	113	35	in	in	IN
cord-027654-k0uby99n	113	36	the	the	DT
cord-027654-k0uby99n	113	37	presence	presence	NN
cord-027654-k0uby99n	113	38	of	of	IN
cord-027654-k0uby99n	113	39	rAd5	rad5	PRP$
cord-027654-k0uby99n	113	40	immunity	immunity	NN
cord-027654-k0uby99n	113	41	has	have	VBZ
cord-027654-k0uby99n	113	42	yet	yet	RB
cord-027654-k0uby99n	113	43	to	to	TO
cord-027654-k0uby99n	113	44	be	be	VB
cord-027654-k0uby99n	113	45	determined	determine	VBN
cord-027654-k0uby99n	113	46	.	.	.
cord-027654-k0uby99n	114	1	In	in	IN
cord-027654-k0uby99n	114	2	addition	addition	NN
cord-027654-k0uby99n	114	3	to	to	IN
cord-027654-k0uby99n	114	4	the	the	DT
cord-027654-k0uby99n	114	5	replication	replication	NN
cord-027654-k0uby99n	114	6	-	-	HYPH
cord-027654-k0uby99n	114	7	incompetent	incompetent	JJ
cord-027654-k0uby99n	114	8	Ad	ad	NN
cord-027654-k0uby99n	114	9	vectors	vector	NNS
cord-027654-k0uby99n	114	10	,	,	,
cord-027654-k0uby99n	114	11	replicationcompetent	replicationcompetent	NN
cord-027654-k0uby99n	114	12	vectors	vector	NNS
cord-027654-k0uby99n	114	13	from	from	IN
cord-027654-k0uby99n	114	14	Ad4	ad4	NN
cord-027654-k0uby99n	114	15	and	and	CC
cord-027654-k0uby99n	114	16	Ad7	ad7	NN
cord-027654-k0uby99n	114	17	have	have	VBP
cord-027654-k0uby99n	114	18	been	be	VBN
cord-027654-k0uby99n	114	19	used	use	VBN
cord-027654-k0uby99n	114	20	as	as	IN
cord-027654-k0uby99n	114	21	vaccine	vaccine	NN
cord-027654-k0uby99n	114	22	vectors	vector	NNS
cord-027654-k0uby99n	114	23	,	,	,
cord-027654-k0uby99n	114	24	either	either	CC
cord-027654-k0uby99n	114	25	for	for	IN
cord-027654-k0uby99n	114	26	immunization	immunization	NN
cord-027654-k0uby99n	114	27	against	against	IN
cord-027654-k0uby99n	114	28	adenovirus	adenovirus	NN
cord-027654-k0uby99n	114	29	infection	infection	NN
cord-027654-k0uby99n	114	30	or	or	CC
cord-027654-k0uby99n	114	31	as	as	IN
cord-027654-k0uby99n	114	32	recombinant	recombinant	JJ
cord-027654-k0uby99n	114	33	vectors	vector	NNS
cord-027654-k0uby99n	114	34	,	,	,
cord-027654-k0uby99n	114	35	for	for	IN
cord-027654-k0uby99n	114	36	example	example	NN
cord-027654-k0uby99n	114	37	,	,	,
cord-027654-k0uby99n	114	38	against	against	IN
cord-027654-k0uby99n	114	39	HIV	HIV	NNP
cord-027654-k0uby99n	114	40	.	.	.
cord-027654-k0uby99n	115	1	54,55	54,55	CD
cord-027654-k0uby99n	116	1	These	these	DT
cord-027654-k0uby99n	116	2	vaccines	vaccine	NNS
cord-027654-k0uby99n	116	3	offer	offer	VBP
cord-027654-k0uby99n	116	4	not	not	RB
cord-027654-k0uby99n	116	5	only	only	RB
cord-027654-k0uby99n	116	6	alternative	alternative	JJ
cord-027654-k0uby99n	116	7	serotypes	serotype	NNS
cord-027654-k0uby99n	116	8	but	but	CC
cord-027654-k0uby99n	116	9	also	also	RB
cord-027654-k0uby99n	116	10	deliver	deliver	VB
cord-027654-k0uby99n	116	11	the	the	DT
cord-027654-k0uby99n	116	12	immune	immune	JJ
cord-027654-k0uby99n	116	13	stimulus	stimulus	NN
cord-027654-k0uby99n	116	14	to	to	IN
cord-027654-k0uby99n	116	15	the	the	DT
cord-027654-k0uby99n	116	16	gut	gut	NN
cord-027654-k0uby99n	116	17	mucosa	mucosa	NN
cord-027654-k0uby99n	116	18	,	,	,
cord-027654-k0uby99n	116	19	which	which	WDT
cord-027654-k0uby99n	116	20	may	may	MD
cord-027654-k0uby99n	116	21	have	have	VB
cord-027654-k0uby99n	116	22	potentially	potentially	RB
cord-027654-k0uby99n	116	23	desirable	desirable	JJ
cord-027654-k0uby99n	116	24	effects	effect	NNS
cord-027654-k0uby99n	116	25	in	in	IN
cord-027654-k0uby99n	116	26	protection	protection	NN
cord-027654-k0uby99n	116	27	against	against	IN
cord-027654-k0uby99n	116	28	some	some	DT
cord-027654-k0uby99n	116	29	diseases	disease	NNS
cord-027654-k0uby99n	116	30	.	.	.
cord-027654-k0uby99n	117	1	Finally	finally	RB
cord-027654-k0uby99n	117	2	,	,	,
cord-027654-k0uby99n	117	3	recombinant	recombinant	JJ
cord-027654-k0uby99n	117	4	Ad	ad	NN
cord-027654-k0uby99n	117	5	vectors	vector	NNS
cord-027654-k0uby99n	117	6	have	have	VBP
cord-027654-k0uby99n	117	7	been	be	VBN
cord-027654-k0uby99n	117	8	developed	develop	VBN
cord-027654-k0uby99n	117	9	from	from	IN
cord-027654-k0uby99n	117	10	alternative	alternative	JJ
cord-027654-k0uby99n	117	11	species	specie	NNS
cord-027654-k0uby99n	117	12	,	,	,
cord-027654-k0uby99n	117	13	including	include	VBG
cord-027654-k0uby99n	117	14	sheep	sheep	NN
cord-027654-k0uby99n	117	15	,	,	,
cord-027654-k0uby99n	117	16	pigs	pig	NNS
cord-027654-k0uby99n	117	17	,	,	,
cord-027654-k0uby99n	117	18	cows	cow	NNS
cord-027654-k0uby99n	117	19	and	and	CC
cord-027654-k0uby99n	117	20	chimpanzees	chimpanzee	NNS
cord-027654-k0uby99n	117	21	.	.	.
cord-027654-k0uby99n	118	1	[	[	-LRB-
cord-027654-k0uby99n	118	2	56	56	CD
cord-027654-k0uby99n	118	3	]	]	-RRB-
cord-027654-k0uby99n	118	4	[	[	-LRB-
cord-027654-k0uby99n	118	5	57	57	CD
cord-027654-k0uby99n	118	6	]	]	-RRB-
cord-027654-k0uby99n	118	7	[	[	-LRB-
cord-027654-k0uby99n	118	8	58	58	CD
cord-027654-k0uby99n	118	9	]	]	-RRB-
cord-027654-k0uby99n	119	1	[	[	-LRB-
cord-027654-k0uby99n	119	2	59	59	CD
cord-027654-k0uby99n	119	3	]	]	-RRB-
cord-027654-k0uby99n	119	4	[	[	-LRB-
cord-027654-k0uby99n	119	5	60	60	CD
cord-027654-k0uby99n	119	6	]	]	-RRB-
cord-027654-k0uby99n	119	7	[	[	-LRB-
cord-027654-k0uby99n	119	8	61	61	CD
cord-027654-k0uby99n	119	9	]	]	-RRB-
cord-027654-k0uby99n	120	1	In	in	IN
cord-027654-k0uby99n	120	2	conclusion	conclusion	NN
cord-027654-k0uby99n	120	3	,	,	,
cord-027654-k0uby99n	120	4	the	the	DT
cord-027654-k0uby99n	120	5	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	120	6	of	of	IN
cord-027654-k0uby99n	120	7	rAd	rAd	NNP
cord-027654-k0uby99n	120	8	vectors	vector	NNS
cord-027654-k0uby99n	120	9	has	have	VBZ
cord-027654-k0uby99n	120	10	prompted	prompt	VBN
cord-027654-k0uby99n	120	11	their	-PRON-	PRP$
cord-027654-k0uby99n	120	12	development	development	NN
cord-027654-k0uby99n	120	13	as	as	IN
cord-027654-k0uby99n	120	14	candidate	candidate	NN
cord-027654-k0uby99n	120	15	vaccines	vaccine	NNS
cord-027654-k0uby99n	120	16	for	for	IN
cord-027654-k0uby99n	120	17	a	a	DT
cord-027654-k0uby99n	120	18	variety	variety	NN
cord-027654-k0uby99n	120	19	of	of	IN
cord-027654-k0uby99n	120	20	infectious	infectious	JJ
cord-027654-k0uby99n	120	21	diseases	disease	NNS
cord-027654-k0uby99n	120	22	.	.	.
cord-027654-k0uby99n	121	1	These	these	DT
cord-027654-k0uby99n	121	2	vectors	vector	NNS
cord-027654-k0uby99n	121	3	are	be	VBP
cord-027654-k0uby99n	121	4	well	well	RB
cord-027654-k0uby99n	121	5	tolerated	tolerate	VBN
cord-027654-k0uby99n	121	6	and	and	CC
cord-027654-k0uby99n	121	7	highly	highly	RB
cord-027654-k0uby99n	121	8	immunogenic	immunogenic	JJ
cord-027654-k0uby99n	121	9	at	at	IN
cord-027654-k0uby99n	121	10	moderate	moderate	JJ
cord-027654-k0uby99n	121	11	doses	dose	NNS
cord-027654-k0uby99n	121	12	.	.	.
cord-027654-k0uby99n	122	1	Whether	whether	IN
cord-027654-k0uby99n	122	2	the	the	DT
cord-027654-k0uby99n	122	3	frequency	frequency	NN
cord-027654-k0uby99n	122	4	of	of	IN
cord-027654-k0uby99n	122	5	preexisting	preexist	VBG
cord-027654-k0uby99n	122	6	Ad5	ad5	CD
cord-027654-k0uby99n	122	7	immunity	immunity	NN
cord-027654-k0uby99n	122	8	may	may	MD
cord-027654-k0uby99n	122	9	compromise	compromise	VB
cord-027654-k0uby99n	122	10	their	-PRON-	PRP$
cord-027654-k0uby99n	122	11	utility	utility	NN
cord-027654-k0uby99n	122	12	in	in	IN
cord-027654-k0uby99n	122	13	humans	human	NNS
cord-027654-k0uby99n	122	14	remains	remain	VBZ
cord-027654-k0uby99n	122	15	to	to	TO
cord-027654-k0uby99n	122	16	be	be	VB
cord-027654-k0uby99n	122	17	determined	determine	VBN
cord-027654-k0uby99n	122	18	;	;	:
cord-027654-k0uby99n	122	19	however	however	RB
cord-027654-k0uby99n	122	20	,	,	,
cord-027654-k0uby99n	122	21	a	a	DT
cord-027654-k0uby99n	122	22	variety	variety	NN
cord-027654-k0uby99n	122	23	of	of	IN
cord-027654-k0uby99n	122	24	strategies	strategy	NNS
cord-027654-k0uby99n	122	25	are	be	VBP
cord-027654-k0uby99n	122	26	under	under	IN
cord-027654-k0uby99n	122	27	development	development	NN
cord-027654-k0uby99n	122	28	to	to	TO
cord-027654-k0uby99n	122	29	overcome	overcome	VB
cord-027654-k0uby99n	122	30	this	this	DT
cord-027654-k0uby99n	122	31	effect	effect	NN
cord-027654-k0uby99n	122	32	should	should	MD
cord-027654-k0uby99n	122	33	it	-PRON-	PRP
cord-027654-k0uby99n	122	34	be	be	VB
cord-027654-k0uby99n	122	35	found	find	VBN
cord-027654-k0uby99n	122	36	.	.	.
cord-027654-k0uby99n	123	1	Novel	novel	JJ
cord-027654-k0uby99n	123	2	delivery	delivery	NN
cord-027654-k0uby99n	123	3	vectors	vector	NNS
cord-027654-k0uby99n	123	4	,	,	,
cord-027654-k0uby99n	123	5	as	as	RB
cord-027654-k0uby99n	123	6	well	well	RB
cord-027654-k0uby99n	123	7	as	as	IN
cord-027654-k0uby99n	123	8	molecularly	molecularly	RB
cord-027654-k0uby99n	123	9	engineered	engineer	VBN
cord-027654-k0uby99n	123	10	rAd5	rAd5	''
cord-027654-k0uby99n	123	11	with	with	IN
cord-027654-k0uby99n	123	12	development	development	NN
cord-027654-k0uby99n	123	13	of	of	IN
cord-027654-k0uby99n	123	14	alternative	alternative	JJ
cord-027654-k0uby99n	123	15	Ad	ad	NN
cord-027654-k0uby99n	123	16	serotypes	serotype	NNS
cord-027654-k0uby99n	123	17	from	from	IN
cord-027654-k0uby99n	123	18	humans	human	NNS
cord-027654-k0uby99n	123	19	or	or	CC
cord-027654-k0uby99n	123	20	other	other	JJ
cord-027654-k0uby99n	123	21	species	specie	NNS
cord-027654-k0uby99n	123	22	should	should	MD
cord-027654-k0uby99n	123	23	provide	provide	VB
cord-027654-k0uby99n	123	24	a	a	DT
cord-027654-k0uby99n	123	25	number	number	NN
cord-027654-k0uby99n	123	26	of	of	IN
cord-027654-k0uby99n	123	27	options	option	NNS
cord-027654-k0uby99n	123	28	to	to	TO
cord-027654-k0uby99n	123	29	expand	expand	VB
cord-027654-k0uby99n	123	30	their	-PRON-	PRP$
cord-027654-k0uby99n	123	31	use	use	NN
cord-027654-k0uby99n	123	32	in	in	IN
cord-027654-k0uby99n	123	33	the	the	DT
cord-027654-k0uby99n	123	34	future	future	NN
cord-027654-k0uby99n	123	35	.	.	.
cord-027654-k0uby99n	124	1	The	the	DT
cord-027654-k0uby99n	124	2	effi	effi	NNP
cord-027654-k0uby99n	124	3	cacy	cacy	NN
cord-027654-k0uby99n	124	4	of	of	IN
cord-027654-k0uby99n	124	5	vaccinia	vaccinia	NN
cord-027654-k0uby99n	124	6	virus	virus	NN
cord-027654-k0uby99n	124	7	as	as	IN
cord-027654-k0uby99n	124	8	a	a	DT
cord-027654-k0uby99n	124	9	vaccine	vaccine	NN
cord-027654-k0uby99n	124	10	vector	vector	NN
cord-027654-k0uby99n	124	11	represents	represent	VBZ
cord-027654-k0uby99n	124	12	one	one	CD
cord-027654-k0uby99n	124	13	of	of	IN
cord-027654-k0uby99n	124	14	the	the	DT
cord-027654-k0uby99n	124	15	most	most	RBS
cord-027654-k0uby99n	124	16	well	well	RB
cord-027654-k0uby99n	124	17	-	-	HYPH
cord-027654-k0uby99n	124	18	documented	document	VBN
cord-027654-k0uby99n	124	19	examples	example	NNS
cord-027654-k0uby99n	124	20	of	of	IN
cord-027654-k0uby99n	124	21	a	a	DT
cord-027654-k0uby99n	124	22	vaccination	vaccination	NN
cord-027654-k0uby99n	124	23	against	against	IN
cord-027654-k0uby99n	124	24	infectious	infectious	JJ
cord-027654-k0uby99n	124	25	diseases	disease	NNS
cord-027654-k0uby99n	124	26	.	.	.
cord-027654-k0uby99n	125	1	Based	base	VBN
cord-027654-k0uby99n	125	2	on	on	IN
cord-027654-k0uby99n	125	3	safety	safety	NN
cord-027654-k0uby99n	125	4	issues	issue	NNS
cord-027654-k0uby99n	125	5	observed	observe	VBN
cord-027654-k0uby99n	125	6	in	in	IN
cord-027654-k0uby99n	125	7	the	the	DT
cord-027654-k0uby99n	125	8	use	use	NN
cord-027654-k0uby99n	125	9	of	of	IN
cord-027654-k0uby99n	125	10	vaccinia	vaccinia	NN
cord-027654-k0uby99n	125	11	strains	strain	NNS
cord-027654-k0uby99n	125	12	against	against	IN
cord-027654-k0uby99n	125	13	smallpox	smallpox	NN
cord-027654-k0uby99n	125	14	,	,	,
cord-027654-k0uby99n	125	15	62	62	CD
cord-027654-k0uby99n	125	16	-	-	SYM
cord-027654-k0uby99n	125	17	65	65	CD
cord-027654-k0uby99n	125	18	a	a	DT
cord-027654-k0uby99n	125	19	number	number	NN
cord-027654-k0uby99n	125	20	of	of	IN
cord-027654-k0uby99n	125	21	alternative	alternative	JJ
cord-027654-k0uby99n	125	22	vaccinia	vaccinia	NN
cord-027654-k0uby99n	125	23	virus	virus	NN
cord-027654-k0uby99n	125	24	strains	strain	NNS
cord-027654-k0uby99n	125	25	have	have	VBP
cord-027654-k0uby99n	125	26	been	be	VBN
cord-027654-k0uby99n	125	27	developed	develop	VBN
cord-027654-k0uby99n	125	28	as	as	IN
cord-027654-k0uby99n	125	29	immunization	immunization	NN
cord-027654-k0uby99n	125	30	vehicles	vehicle	NNS
cord-027654-k0uby99n	125	31	.	.	.
cord-027654-k0uby99n	126	1	To	to	TO
cord-027654-k0uby99n	126	2	avoid	avoid	VB
cord-027654-k0uby99n	126	3	these	these	DT
cord-027654-k0uby99n	126	4	complications	complication	NNS
cord-027654-k0uby99n	126	5	,	,	,
cord-027654-k0uby99n	126	6	several	several	JJ
cord-027654-k0uby99n	126	7	highly	highly	RB
cord-027654-k0uby99n	126	8	attenuated	attenuated	JJ
cord-027654-k0uby99n	126	9	virus	virus	NN
cord-027654-k0uby99n	126	10	vaccine	vaccine	NN
cord-027654-k0uby99n	126	11	vectors	vector	NNS
cord-027654-k0uby99n	126	12	have	have	VBP
cord-027654-k0uby99n	126	13	been	be	VBN
cord-027654-k0uby99n	126	14	described	describe	VBN
cord-027654-k0uby99n	126	15	,	,	,
cord-027654-k0uby99n	126	16	as	as	RB
cord-027654-k0uby99n	126	17	well	well	RB
cord-027654-k0uby99n	126	18	as	as	IN
cord-027654-k0uby99n	126	19	avipox	avipox	NNP
cord-027654-k0uby99n	126	20	and	and	CC
cord-027654-k0uby99n	126	21	fowlpox	fowlpox	NNP
cord-027654-k0uby99n	126	22	vectors	vector	NNS
cord-027654-k0uby99n	126	23	.	.	.
cord-027654-k0uby99n	127	1	These	these	DT
cord-027654-k0uby99n	127	2	strains	strain	NNS
cord-027654-k0uby99n	127	3	are	be	VBP
cord-027654-k0uby99n	127	4	listed	list	VBN
cord-027654-k0uby99n	127	5	in	in	IN
cord-027654-k0uby99n	127	6	Table	Table	NNP
cord-027654-k0uby99n	127	7	 	 	_SP
cord-027654-k0uby99n	127	8	62	62	CD
cord-027654-k0uby99n	127	9	-3	-3	NNP
cord-027654-k0uby99n	127	10	.	.	.
cord-027654-k0uby99n	128	1	The	the	DT
cord-027654-k0uby99n	128	2	development	development	NN
cord-027654-k0uby99n	128	3	of	of	IN
cord-027654-k0uby99n	128	4	such	such	JJ
cord-027654-k0uby99n	128	5	attenuated	attenuated	JJ
cord-027654-k0uby99n	128	6	vaccinia	vaccinia	NN
cord-027654-k0uby99n	128	7	viruses	virus	NNS
cord-027654-k0uby99n	128	8	also	also	RB
cord-027654-k0uby99n	128	9	promoted	promote	VBD
cord-027654-k0uby99n	128	10	their	-PRON-	PRP$
cord-027654-k0uby99n	128	11	use	use	NN
cord-027654-k0uby99n	128	12	as	as	IN
cord-027654-k0uby99n	128	13	delivery	delivery	NN
cord-027654-k0uby99n	128	14	vectors	vector	NNS
cord-027654-k0uby99n	128	15	for	for	IN
cord-027654-k0uby99n	128	16	gene	gene	NN
cord-027654-k0uby99n	128	17	products	product	NNS
cord-027654-k0uby99n	128	18	against	against	IN
cord-027654-k0uby99n	128	19	specifi	specifi	NNP
cord-027654-k0uby99n	128	20	c	c	NN
cord-027654-k0uby99n	128	21	pathogens	pathogen	NNS
cord-027654-k0uby99n	128	22	other	other	JJ
cord-027654-k0uby99n	128	23	than	than	IN
cord-027654-k0uby99n	128	24	smallpox	smallpox	NN
cord-027654-k0uby99n	128	25	and	and	CC
cord-027654-k0uby99n	128	26	the	the	DT
cord-027654-k0uby99n	128	27	use	use	NN
cord-027654-k0uby99n	128	28	of	of	IN
cord-027654-k0uby99n	128	29	these	these	DT
cord-027654-k0uby99n	128	30	vectors	vector	NNS
cord-027654-k0uby99n	128	31	has	have	VBZ
cord-027654-k0uby99n	128	32	now	now	RB
cord-027654-k0uby99n	128	33	been	be	VBN
cord-027654-k0uby99n	128	34	explored	explore	VBN
cord-027654-k0uby99n	128	35	extensively	extensively	RB
cord-027654-k0uby99n	128	36	in	in	IN
cord-027654-k0uby99n	128	37	a	a	DT
cord-027654-k0uby99n	128	38	variety	variety	NN
cord-027654-k0uby99n	128	39	of	of	IN
cord-027654-k0uby99n	128	40	infectious	infectious	JJ
cord-027654-k0uby99n	128	41	disease	disease	NN
cord-027654-k0uby99n	128	42	models	model	NNS
cord-027654-k0uby99n	128	43	.	.	.
cord-027654-k0uby99n	129	1	One	one	CD
cord-027654-k0uby99n	129	2	of	of	IN
cord-027654-k0uby99n	129	3	the	the	DT
cord-027654-k0uby99n	129	4	two	two	CD
cord-027654-k0uby99n	129	5	major	major	JJ
cord-027654-k0uby99n	129	6	attenuated	attenuated	JJ
cord-027654-k0uby99n	129	7	strains	strain	NNS
cord-027654-k0uby99n	129	8	of	of	IN
cord-027654-k0uby99n	129	9	poxvirus	poxvirus	NNP
cord-027654-k0uby99n	129	10	is	be	VBZ
cord-027654-k0uby99n	129	11	modifi	modifi	NNP
cord-027654-k0uby99n	129	12	ed	ed	NNP
cord-027654-k0uby99n	129	13	vaccinia	vaccinia	NN
cord-027654-k0uby99n	129	14	Ankara	Ankara	NNP
cord-027654-k0uby99n	129	15	(	(	-LRB-
cord-027654-k0uby99n	129	16	MVA	MVA	NNP
cord-027654-k0uby99n	129	17	)	)	-RRB-
cord-027654-k0uby99n	129	18	,	,	,
cord-027654-k0uby99n	129	19	developed	develop	VBN
cord-027654-k0uby99n	129	20	by	by	IN
cord-027654-k0uby99n	129	21	repeated	repeat	VBN
cord-027654-k0uby99n	129	22	passaging	passaging	NN
cord-027654-k0uby99n	129	23	of	of	IN
cord-027654-k0uby99n	129	24	the	the	DT
cord-027654-k0uby99n	129	25	Ankara	Ankara	NNP
cord-027654-k0uby99n	129	26	strain	strain	NN
cord-027654-k0uby99n	129	27	on	on	IN
cord-027654-k0uby99n	129	28	primary	primary	JJ
cord-027654-k0uby99n	129	29	chicken	chicken	NN
cord-027654-k0uby99n	129	30	embryo	embryo	NN
cord-027654-k0uby99n	129	31	fi	fi	NN
cord-027654-k0uby99n	129	32	broblasts	broblast	NNS
cord-027654-k0uby99n	129	33	.	.	.
cord-027654-k0uby99n	130	1	This	this	DT
cord-027654-k0uby99n	130	2	resulted	result	VBD
cord-027654-k0uby99n	130	3	in	in	IN
cord-027654-k0uby99n	130	4	the	the	DT
cord-027654-k0uby99n	130	5	ability	ability	NN
cord-027654-k0uby99n	130	6	of	of	IN
cord-027654-k0uby99n	130	7	the	the	DT
cord-027654-k0uby99n	130	8	virus	virus	NN
cord-027654-k0uby99n	130	9	to	to	TO
cord-027654-k0uby99n	130	10	replicate	replicate	VB
cord-027654-k0uby99n	130	11	effi	effi	NNP
cord-027654-k0uby99n	130	12	ciently	ciently	RB
cord-027654-k0uby99n	130	13	on	on	IN
cord-027654-k0uby99n	130	14	a	a	DT
cord-027654-k0uby99n	130	15	variety	variety	NN
cord-027654-k0uby99n	130	16	of	of	IN
cord-027654-k0uby99n	130	17	non	non	JJ
cord-027654-k0uby99n	130	18	-	-	JJ
cord-027654-k0uby99n	130	19	avian	avian	JJ
cord-027654-k0uby99n	130	20	cell	cell	NN
cord-027654-k0uby99n	130	21	types	type	NNS
cord-027654-k0uby99n	130	22	because	because	IN
cord-027654-k0uby99n	130	23	of	of	IN
cord-027654-k0uby99n	130	24	multiple	multiple	JJ
cord-027654-k0uby99n	130	25	genetic	genetic	JJ
cord-027654-k0uby99n	130	26	changes	change	NNS
cord-027654-k0uby99n	130	27	,	,	,
cord-027654-k0uby99n	130	28	which	which	WDT
cord-027654-k0uby99n	130	29	facilitates	facilitate	VBZ
cord-027654-k0uby99n	130	30	its	-PRON-	PRP$
cord-027654-k0uby99n	130	31	propagation	propagation	NN
cord-027654-k0uby99n	130	32	and	and	CC
cord-027654-k0uby99n	130	33	use	use	NN
cord-027654-k0uby99n	130	34	as	as	IN
cord-027654-k0uby99n	130	35	a	a	DT
cord-027654-k0uby99n	130	36	vector	vector	NN
cord-027654-k0uby99n	130	37	.	.	.
cord-027654-k0uby99n	131	1	An	an	DT
cord-027654-k0uby99n	131	2	alternative	alternative	JJ
cord-027654-k0uby99n	131	3	attenuated	attenuated	JJ
cord-027654-k0uby99n	131	4	strain	strain	NN
cord-027654-k0uby99n	131	5	,	,	,
cord-027654-k0uby99n	131	6	the	the	DT
cord-027654-k0uby99n	131	7	New	New	NNP
cord-027654-k0uby99n	131	8	York	York	NNP
cord-027654-k0uby99n	131	9	vaccinia	vaccinia	NN
cord-027654-k0uby99n	131	10	strain	strain	NN
cord-027654-k0uby99n	131	11	,	,	,
cord-027654-k0uby99n	131	12	NYVAC	NYVAC	NNP
cord-027654-k0uby99n	131	13	,	,	,
cord-027654-k0uby99n	131	14	was	be	VBD
cord-027654-k0uby99n	131	15	developed	develop	VBN
cord-027654-k0uby99n	131	16	by	by	IN
cord-027654-k0uby99n	131	17	genetic	genetic	JJ
cord-027654-k0uby99n	131	18	modifi	modifi	NNP
cord-027654-k0uby99n	131	19	cation	cation	NN
cord-027654-k0uby99n	131	20	of	of	IN
cord-027654-k0uby99n	131	21	the	the	DT
cord-027654-k0uby99n	131	22	viral	viral	JJ
cord-027654-k0uby99n	131	23	genome	genome	NN
cord-027654-k0uby99n	131	24	,	,	,
cord-027654-k0uby99n	131	25	including	include	VBG
cord-027654-k0uby99n	131	26	the	the	DT
cord-027654-k0uby99n	131	27	deletion	deletion	NN
cord-027654-k0uby99n	131	28	of	of	IN
cord-027654-k0uby99n	131	29	18	18	CD
cord-027654-k0uby99n	131	30	open	open	JJ
cord-027654-k0uby99n	131	31	reading	reading	NN
cord-027654-k0uby99n	131	32	frames	frame	NNS
cord-027654-k0uby99n	131	33	associated	associate	VBN
cord-027654-k0uby99n	131	34	with	with	IN
cord-027654-k0uby99n	131	35	virulence	virulence	NN
cord-027654-k0uby99n	131	36	and	and	CC
cord-027654-k0uby99n	131	37	host	host	NN
cord-027654-k0uby99n	131	38	range	range	NN
cord-027654-k0uby99n	131	39	in	in	IN
cord-027654-k0uby99n	131	40	the	the	DT
cord-027654-k0uby99n	131	41	Copenhagen	Copenhagen	NNP
cord-027654-k0uby99n	131	42	strain	strain	NN
cord-027654-k0uby99n	131	43	.	.	.
cord-027654-k0uby99n	132	1	66	66	CD
cord-027654-k0uby99n	132	2	-	-	SYM
cord-027654-k0uby99n	132	3	69	69	CD
cord-027654-k0uby99n	132	4	NYVAC	NYVAC	NNP
cord-027654-k0uby99n	132	5	,	,	,
cord-027654-k0uby99n	132	6	like	like	IN
cord-027654-k0uby99n	132	7	MVA	MVA	NNP
cord-027654-k0uby99n	132	8	,	,	,
cord-027654-k0uby99n	132	9	is	be	VBZ
cord-027654-k0uby99n	132	10	attenuated	attenuate	VBN
cord-027654-k0uby99n	132	11	in	in	IN
cord-027654-k0uby99n	132	12	animal	animal	NN
cord-027654-k0uby99n	132	13	models	model	NNS
cord-027654-k0uby99n	132	14	and	and	CC
cord-027654-k0uby99n	132	15	shows	show	VBZ
cord-027654-k0uby99n	132	16	favorable	favorable	JJ
cord-027654-k0uby99n	132	17	safety	safety	NN
cord-027654-k0uby99n	132	18	and	and	CC
cord-027654-k0uby99n	132	19	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	132	20	in	in	IN
cord-027654-k0uby99n	132	21	animals	animal	NNS
cord-027654-k0uby99n	132	22	and	and	CC
cord-027654-k0uby99n	132	23	humans	human	NNS
cord-027654-k0uby99n	132	24	.	.	.
cord-027654-k0uby99n	133	1	67	67	CD
cord-027654-k0uby99n	133	2	,	,	,
cord-027654-k0uby99n	133	3	70	70	CD
cord-027654-k0uby99n	133	4	,	,	,
cord-027654-k0uby99n	133	5	71	71	CD
cord-027654-k0uby99n	134	1	This	this	DT
cord-027654-k0uby99n	134	2	virus	virus	NN
cord-027654-k0uby99n	134	3	also	also	RB
cord-027654-k0uby99n	134	4	shows	show	VBZ
cord-027654-k0uby99n	134	5	block	block	NN
cord-027654-k0uby99n	134	6	at	at	IN
cord-027654-k0uby99n	134	7	an	an	DT
cord-027654-k0uby99n	134	8	early	early	JJ
cord-027654-k0uby99n	134	9	stage	stage	NN
cord-027654-k0uby99n	134	10	of	of	IN
cord-027654-k0uby99n	134	11	replication	replication	NN
cord-027654-k0uby99n	134	12	,	,	,
cord-027654-k0uby99n	134	13	though	though	IN
cord-027654-k0uby99n	134	14	it	-PRON-	PRP
cord-027654-k0uby99n	134	15	is	be	VBZ
cord-027654-k0uby99n	134	16	able	able	JJ
cord-027654-k0uby99n	134	17	to	to	TO
cord-027654-k0uby99n	134	18	replicate	replicate	VB
cord-027654-k0uby99n	134	19	productively	productively	RB
cord-027654-k0uby99n	134	20	in	in	IN
cord-027654-k0uby99n	134	21	African	african	JJ
cord-027654-k0uby99n	134	22	green	green	JJ
cord-027654-k0uby99n	134	23	monkey	monkey	NN
cord-027654-k0uby99n	134	24	kidney	kidney	NN
cord-027654-k0uby99n	134	25	cells	cell	NNS
cord-027654-k0uby99n	134	26	and	and	CC
cord-027654-k0uby99n	134	27	primary	primary	JJ
cord-027654-k0uby99n	134	28	chicken	chicken	NN
cord-027654-k0uby99n	134	29	embryo	embryo	NN
cord-027654-k0uby99n	134	30	fi	fi	NN
cord-027654-k0uby99n	134	31	broblasts	broblasts	NNP
cord-027654-k0uby99n	134	32	(	(	-LRB-
cord-027654-k0uby99n	134	33	CEF	CEF	NNP
cord-027654-k0uby99n	134	34	)	)	-RRB-
cord-027654-k0uby99n	134	35	.	.	.
cord-027654-k0uby99n	135	1	The	the	DT
cord-027654-k0uby99n	135	2	avipox	avipox	NN
cord-027654-k0uby99n	135	3	vectors	vector	NNS
cord-027654-k0uby99n	135	4	include	include	VBP
cord-027654-k0uby99n	135	5	fowlpox	fowlpox	NNP
cord-027654-k0uby99n	135	6	and	and	CC
cord-027654-k0uby99n	135	7	canarypox	canarypox	NN
cord-027654-k0uby99n	135	8	as	as	RB
cord-027654-k0uby99n	135	9	well	well	RB
cord-027654-k0uby99n	135	10	as	as	IN
cord-027654-k0uby99n	135	11	ALVAC	ALVAC	NNP
cord-027654-k0uby99n	135	12	.	.	.
cord-027654-k0uby99n	136	1	ALVAC	ALVAC	NNP
cord-027654-k0uby99n	136	2	is	be	VBZ
cord-027654-k0uby99n	136	3	derived	derive	VBN
cord-027654-k0uby99n	136	4	from	from	IN
cord-027654-k0uby99n	136	5	a	a	DT
cord-027654-k0uby99n	136	6	plaque	plaque	NN
cord-027654-k0uby99n	136	7	-	-	HYPH
cord-027654-k0uby99n	136	8	purifi	purifi	NN
cord-027654-k0uby99n	136	9	ed	ed	NN
cord-027654-k0uby99n	136	10	virus	virus	NN
cord-027654-k0uby99n	136	11	isolated	isolate	VBN
cord-027654-k0uby99n	136	12	from	from	IN
cord-027654-k0uby99n	136	13	an	an	DT
cord-027654-k0uby99n	136	14	existing	exist	VBG
cord-027654-k0uby99n	136	15	canarypox	canarypox	NN
cord-027654-k0uby99n	136	16	strain	strain	NN
cord-027654-k0uby99n	136	17	,	,	,
cord-027654-k0uby99n	136	18	canapox	canapox	NNP
cord-027654-k0uby99n	136	19	.	.	.
cord-027654-k0uby99n	137	1	72	72	CD
cord-027654-k0uby99n	137	2	ALVAC	ALVAC	NNP
cord-027654-k0uby99n	137	3	is	be	VBZ
cord-027654-k0uby99n	137	4	able	able	JJ
cord-027654-k0uby99n	137	5	to	to	TO
cord-027654-k0uby99n	137	6	express	express	VB
cord-027654-k0uby99n	137	7	inserted	insert	VBN
cord-027654-k0uby99n	137	8	transgenes	transgene	NNS
cord-027654-k0uby99n	137	9	and	and	CC
cord-027654-k0uby99n	137	10	has	have	VBZ
cord-027654-k0uby99n	137	11	been	be	VBN
cord-027654-k0uby99n	137	12	shown	show	VBN
cord-027654-k0uby99n	137	13	to	to	TO
cord-027654-k0uby99n	137	14	be	be	VB
cord-027654-k0uby99n	137	15	immunogenic	immunogenic	JJ
cord-027654-k0uby99n	137	16	in	in	IN
cord-027654-k0uby99n	137	17	both	both	DT
cord-027654-k0uby99n	137	18	animal	animal	NN
cord-027654-k0uby99n	137	19	and	and	CC
cord-027654-k0uby99n	137	20	early	early	JJ
cord-027654-k0uby99n	137	21	clinical	clinical	JJ
cord-027654-k0uby99n	137	22	trials	trial	NNS
cord-027654-k0uby99n	137	23	.	.	.
cord-027654-k0uby99n	138	1	70	70	CD
cord-027654-k0uby99n	138	2	,	,	,
cord-027654-k0uby99n	138	3	71	71	CD
cord-027654-k0uby99n	138	4	,	,	,
cord-027654-k0uby99n	138	5	[	[	-LRB-
cord-027654-k0uby99n	138	6	73	73	CD
cord-027654-k0uby99n	138	7	]	]	-RRB-
cord-027654-k0uby99n	138	8	[	[	-LRB-
cord-027654-k0uby99n	138	9	74	74	CD
cord-027654-k0uby99n	138	10	]	]	-RRB-
cord-027654-k0uby99n	138	11	[	[	-LRB-
cord-027654-k0uby99n	138	12	75	75	CD
cord-027654-k0uby99n	138	13	]	]	-RRB-
cord-027654-k0uby99n	138	14	[	[	-LRB-
cord-027654-k0uby99n	138	15	76	76	CD
cord-027654-k0uby99n	138	16	]	]	-RRB-
cord-027654-k0uby99n	139	1	These	these	DT
cord-027654-k0uby99n	139	2	vectors	vector	NNS
cord-027654-k0uby99n	139	3	have	have	VBP
cord-027654-k0uby99n	139	4	been	be	VBN
cord-027654-k0uby99n	139	5	evaluated	evaluate	VBN
cord-027654-k0uby99n	139	6	both	both	CC
cord-027654-k0uby99n	139	7	alone	alone	JJ
cord-027654-k0uby99n	139	8	and	and	CC
cord-027654-k0uby99n	139	9	in	in	IN
cord-027654-k0uby99n	139	10	primeboost	primeboost	JJ
cord-027654-k0uby99n	139	11	combinations	combination	NNS
cord-027654-k0uby99n	139	12	in	in	IN
cord-027654-k0uby99n	139	13	a	a	DT
cord-027654-k0uby99n	139	14	variety	variety	NN
cord-027654-k0uby99n	139	15	of	of	IN
cord-027654-k0uby99n	139	16	infectious	infectious	JJ
cord-027654-k0uby99n	139	17	disease	disease	NN
cord-027654-k0uby99n	139	18	and	and	CC
cord-027654-k0uby99n	139	19	cancer	cancer	NN
cord-027654-k0uby99n	139	20	models	model	NNS
cord-027654-k0uby99n	139	21	(	(	-LRB-
cord-027654-k0uby99n	139	22	reviewed	review	VBN
cord-027654-k0uby99n	139	23	in	in	IN
cord-027654-k0uby99n	139	24	ref	ref	NN
cord-027654-k0uby99n	139	25	.	.	.
cord-027654-k0uby99n	140	1	70	70	CD
cord-027654-k0uby99n	140	2	)	)	-RRB-
cord-027654-k0uby99n	140	3	.	.	.
cord-027654-k0uby99n	141	1	Poxviruses	poxvirus	NNS
cord-027654-k0uby99n	141	2	are	be	VBP
cord-027654-k0uby99n	141	3	notable	notable	JJ
cord-027654-k0uby99n	141	4	for	for	IN
cord-027654-k0uby99n	141	5	their	-PRON-	PRP$
cord-027654-k0uby99n	141	6	large	large	JJ
cord-027654-k0uby99n	141	7	genome	genome	NN
cord-027654-k0uby99n	141	8	size	size	NN
cord-027654-k0uby99n	141	9	and	and	CC
cord-027654-k0uby99n	141	10	their	-PRON-	PRP$
cord-027654-k0uby99n	141	11	ability	ability	NN
cord-027654-k0uby99n	141	12	to	to	TO
cord-027654-k0uby99n	141	13	express	express	VB
cord-027654-k0uby99n	141	14	recombinant	recombinant	JJ
cord-027654-k0uby99n	141	15	genes	gene	NNS
cord-027654-k0uby99n	141	16	without	without	IN
cord-027654-k0uby99n	141	17	an	an	DT
cord-027654-k0uby99n	141	18	effect	effect	NN
cord-027654-k0uby99n	141	19	on	on	IN
cord-027654-k0uby99n	141	20	their	-PRON-	PRP$
cord-027654-k0uby99n	141	21	replication	replication	NN
cord-027654-k0uby99n	141	22	capacity	capacity	NN
cord-027654-k0uby99n	141	23	.	.	.
cord-027654-k0uby99n	142	1	Polyvalent	Polyvalent	NNP
cord-027654-k0uby99n	142	2	recombinants	recombinant	NNS
cord-027654-k0uby99n	142	3	have	have	VBP
cord-027654-k0uby99n	142	4	been	be	VBN
cord-027654-k0uby99n	142	5	used	use	VBN
cord-027654-k0uby99n	142	6	to	to	TO
cord-027654-k0uby99n	142	7	immunize	immunize	VB
cord-027654-k0uby99n	142	8	experimental	experimental	JJ
cord-027654-k0uby99n	142	9	animals	animal	NNS
cord-027654-k0uby99n	142	10	and	and	CC
cord-027654-k0uby99n	142	11	have	have	VBP
cord-027654-k0uby99n	142	12	proven	prove	VBN
cord-027654-k0uby99n	142	13	useful	useful	JJ
cord-027654-k0uby99n	142	14	in	in	IN
cord-027654-k0uby99n	142	15	a	a	DT
cord-027654-k0uby99n	142	16	variety	variety	NN
cord-027654-k0uby99n	142	17	of	of	IN
cord-027654-k0uby99n	142	18	infectious	infectious	JJ
cord-027654-k0uby99n	142	19	disease	disease	NN
cord-027654-k0uby99n	142	20	models	model	NNS
cord-027654-k0uby99n	142	21	,	,	,
cord-027654-k0uby99n	142	22	including	include	VBG
cord-027654-k0uby99n	142	23	rabies	rabie	NNS
cord-027654-k0uby99n	142	24	,	,	,
cord-027654-k0uby99n	142	25	measles	measle	NNS
cord-027654-k0uby99n	142	26	,	,	,
cord-027654-k0uby99n	142	27	SIV	SIV	NNP
cord-027654-k0uby99n	142	28	,	,	,
cord-027654-k0uby99n	142	29	canine	canine	JJ
cord-027654-k0uby99n	142	30	distemper	distemper	NN
cord-027654-k0uby99n	142	31	,	,	,
cord-027654-k0uby99n	142	32	RSV	RSV	NNP
cord-027654-k0uby99n	142	33	,	,	,
cord-027654-k0uby99n	142	34	77	77	CD
cord-027654-k0uby99n	143	1	In	in	IN
cord-027654-k0uby99n	143	2	addition	addition	NN
cord-027654-k0uby99n	143	3	,	,	,
cord-027654-k0uby99n	143	4	these	these	DT
cord-027654-k0uby99n	143	5	vectors	vector	NNS
cord-027654-k0uby99n	143	6	have	have	VBP
cord-027654-k0uby99n	143	7	been	be	VBN
cord-027654-k0uby99n	143	8	studied	study	VBN
cord-027654-k0uby99n	143	9	in	in	IN
cord-027654-k0uby99n	143	10	a	a	DT
cord-027654-k0uby99n	143	11	variety	variety	NN
cord-027654-k0uby99n	143	12	of	of	IN
cord-027654-k0uby99n	143	13	HIV	HIV	NNP
cord-027654-k0uby99n	143	14	challenge	challenge	NN
cord-027654-k0uby99n	143	15	models	model	NNS
cord-027654-k0uby99n	143	16	,	,	,
cord-027654-k0uby99n	143	17	both	both	DT
cord-027654-k0uby99n	143	18	in	in	IN
cord-027654-k0uby99n	143	19	preclinical	preclinical	JJ
cord-027654-k0uby99n	143	20	studies	study	NNS
cord-027654-k0uby99n	143	21	and	and	CC
cord-027654-k0uby99n	143	22	in	in	IN
cord-027654-k0uby99n	143	23	humans	human	NNS
cord-027654-k0uby99n	143	24	[	[	-LRB-
cord-027654-k0uby99n	143	25	78	78	CD
cord-027654-k0uby99n	143	26	]	]	-RRB-
cord-027654-k0uby99n	143	27	[	[	-LRB-
cord-027654-k0uby99n	143	28	79	79	CD
cord-027654-k0uby99n	143	29	]	]	-RRB-
cord-027654-k0uby99n	144	1	[	[	-LRB-
cord-027654-k0uby99n	144	2	80	80	CD
cord-027654-k0uby99n	144	3	]	]	-RRB-
cord-027654-k0uby99n	145	1	[	[	-LRB-
cord-027654-k0uby99n	145	2	81	81	CD
cord-027654-k0uby99n	145	3	]	]	-RRB-
cord-027654-k0uby99n	146	1	[	[	-LRB-
cord-027654-k0uby99n	146	2	82	82	CD
cord-027654-k0uby99n	146	3	]	]	-RRB-
cord-027654-k0uby99n	147	1	[	[	-LRB-
cord-027654-k0uby99n	147	2	83	83	CD
cord-027654-k0uby99n	147	3	]	]	-RRB-
cord-027654-k0uby99n	147	4	and	and	CC
cord-027654-k0uby99n	147	5	human	human	JJ
cord-027654-k0uby99n	147	6	studies	study	NNS
cord-027654-k0uby99n	147	7	have	have	VBP
cord-027654-k0uby99n	147	8	been	be	VBN
cord-027654-k0uby99n	147	9	undertaken	undertake	VBN
cord-027654-k0uby99n	147	10	with	with	IN
cord-027654-k0uby99n	147	11	vaccinia	vaccinia	NN
cord-027654-k0uby99n	147	12	,	,	,
cord-027654-k0uby99n	147	13	84	84	CD
cord-027654-k0uby99n	147	14	-	-	SYM
cord-027654-k0uby99n	147	15	92	92	CD
cord-027654-k0uby99n	147	16	NYVAC	NYVAC	NNP
cord-027654-k0uby99n	147	17	93	93	CD
cord-027654-k0uby99n	147	18	-	-	HYPH
cord-027654-k0uby99n	147	19	96	96	CD
cord-027654-k0uby99n	147	20	and	and	CC
cord-027654-k0uby99n	147	21	ALVAC	ALVAC	NNP
cord-027654-k0uby99n	147	22	.	.	.
cord-027654-k0uby99n	148	1	93	93	CD
cord-027654-k0uby99n	148	2	,	,	,
cord-027654-k0uby99n	148	3	94	94	CD
cord-027654-k0uby99n	148	4	,	,	,
cord-027654-k0uby99n	148	5	[	[	-LRB-
cord-027654-k0uby99n	148	6	96	96	CD
cord-027654-k0uby99n	148	7	]	]	-RRB-
cord-027654-k0uby99n	149	1	[	[	-LRB-
cord-027654-k0uby99n	149	2	97	97	CD
cord-027654-k0uby99n	149	3	]	]	-RRB-
cord-027654-k0uby99n	149	4	[	[	-LRB-
cord-027654-k0uby99n	149	5	98	98	CD
cord-027654-k0uby99n	149	6	]	]	-RRB-
cord-027654-k0uby99n	150	1	[	[	-LRB-
cord-027654-k0uby99n	150	2	99	99	CD
cord-027654-k0uby99n	150	3	]	]	-RRB-
cord-027654-k0uby99n	150	4	[	[	-LRB-
cord-027654-k0uby99n	150	5	100	100	CD
cord-027654-k0uby99n	150	6	]	]	-RRB-
cord-027654-k0uby99n	151	1	[	[	-LRB-
cord-027654-k0uby99n	151	2	101	101	CD
cord-027654-k0uby99n	151	3	]	]	-RRB-
cord-027654-k0uby99n	152	1	To	to	IN
cord-027654-k0uby99n	152	2	date	date	NN
cord-027654-k0uby99n	152	3	,	,	,
cord-027654-k0uby99n	152	4	these	these	DT
cord-027654-k0uby99n	152	5	vectors	vector	NNS
cord-027654-k0uby99n	152	6	have	have	VBP
cord-027654-k0uby99n	152	7	shown	show	VBN
cord-027654-k0uby99n	152	8	marginal	marginal	JJ
cord-027654-k0uby99n	152	9	effi	effi	NNP
cord-027654-k0uby99n	152	10	cacy	cacy	NN
cord-027654-k0uby99n	152	11	that	that	WDT
cord-027654-k0uby99n	152	12	has	have	VBZ
cord-027654-k0uby99n	152	13	limited	limit	VBN
cord-027654-k0uby99n	152	14	their	-PRON-	PRP$
cord-027654-k0uby99n	152	15	ability	ability	NN
cord-027654-k0uby99n	152	16	to	to	TO
cord-027654-k0uby99n	152	17	be	be	VB
cord-027654-k0uby99n	152	18	tested	test	VBN
cord-027654-k0uby99n	152	19	for	for	IN
cord-027654-k0uby99n	152	20	effi	effi	NNP
cord-027654-k0uby99n	152	21	cacy	cacy	NNP
cord-027654-k0uby99n	152	22	in	in	IN
cord-027654-k0uby99n	152	23	human	human	JJ
cord-027654-k0uby99n	152	24	studies	study	NNS
cord-027654-k0uby99n	152	25	,	,	,
cord-027654-k0uby99n	152	26	with	with	IN
cord-027654-k0uby99n	152	27	CTL	CTL	NNP
cord-027654-k0uby99n	152	28	response	response	NN
cord-027654-k0uby99n	152	29	rates	rate	NNS
cord-027654-k0uby99n	152	30	generally	generally	RB
cord-027654-k0uby99n	152	31	<	<	XX
cord-027654-k0uby99n	152	32	35	35	CD
cord-027654-k0uby99n	152	33	%	%	NN
cord-027654-k0uby99n	152	34	,	,	,
cord-027654-k0uby99n	152	35	although	although	IN
cord-027654-k0uby99n	152	36	ALVAC	ALVAC	NNP
cord-027654-k0uby99n	152	37	-	-	HYPH
cord-027654-k0uby99n	152	38	Env(clade	env(clade	NN
cord-027654-k0uby99n	152	39	E)Gag	e)gag	NN
cord-027654-k0uby99n	152	40	/	/	SYM
cord-027654-k0uby99n	152	41	Pol(clade	pol(clade	JJ
cord-027654-k0uby99n	152	42	B	B	NNP
cord-027654-k0uby99n	152	43	)	)	-RRB-
cord-027654-k0uby99n	152	44	is	be	VBZ
cord-027654-k0uby99n	152	45	currently	currently	RB
cord-027654-k0uby99n	152	46	under	under	IN
cord-027654-k0uby99n	152	47	evaluation	evaluation	NN
cord-027654-k0uby99n	152	48	in	in	IN
cord-027654-k0uby99n	152	49	a	a	DT
cord-027654-k0uby99n	152	50	Phase	Phase	NNP
cord-027654-k0uby99n	152	51	III	iii	CD
cord-027654-k0uby99n	152	52	study	study	NN
cord-027654-k0uby99n	152	53	in	in	IN
cord-027654-k0uby99n	152	54	Thailand	Thailand	NNP
cord-027654-k0uby99n	152	55	.	.	.
cord-027654-k0uby99n	153	1	Such	such	JJ
cord-027654-k0uby99n	153	2	poxvirus	poxvirus	JJ
cord-027654-k0uby99n	153	3	vectors	vector	NNS
cord-027654-k0uby99n	153	4	have	have	VBP
cord-027654-k0uby99n	153	5	also	also	RB
cord-027654-k0uby99n	153	6	been	be	VBN
cord-027654-k0uby99n	153	7	evaluated	evaluate	VBN
cord-027654-k0uby99n	153	8	in	in	IN
cord-027654-k0uby99n	153	9	cancer	cancer	NN
cord-027654-k0uby99n	153	10	immunotherapy	immunotherapy	NN
cord-027654-k0uby99n	153	11	protocols	protocol	NNS
cord-027654-k0uby99n	153	12	.	.	.
cord-027654-k0uby99n	154	1	While	while	IN
cord-027654-k0uby99n	154	2	attenuated	attenuated	JJ
cord-027654-k0uby99n	154	3	poxvectors	poxvector	NNS
cord-027654-k0uby99n	154	4	have	have	VBP
cord-027654-k0uby99n	154	5	been	be	VBN
cord-027654-k0uby99n	154	6	evaluated	evaluate	VBN
cord-027654-k0uby99n	154	7	in	in	IN
cord-027654-k0uby99n	154	8	a	a	DT
cord-027654-k0uby99n	154	9	variety	variety	NN
cord-027654-k0uby99n	154	10	of	of	IN
cord-027654-k0uby99n	154	11	human	human	JJ
cord-027654-k0uby99n	154	12	studies	study	NNS
cord-027654-k0uby99n	154	13	,	,	,
cord-027654-k0uby99n	154	14	it	-PRON-	PRP
cord-027654-k0uby99n	154	15	is	be	VBZ
cord-027654-k0uby99n	154	16	clear	clear	JJ
cord-027654-k0uby99n	154	17	that	that	IN
cord-027654-k0uby99n	154	18	it	-PRON-	PRP
cord-027654-k0uby99n	154	19	has	have	VBZ
cord-027654-k0uby99n	154	20	been	be	VBN
cord-027654-k0uby99n	154	21	more	more	RBR
cord-027654-k0uby99n	154	22	challenging	challenging	JJ
cord-027654-k0uby99n	154	23	to	to	TO
cord-027654-k0uby99n	154	24	develop	develop	VB
cord-027654-k0uby99n	154	25	these	these	DT
cord-027654-k0uby99n	154	26	vaccines	vaccine	NNS
cord-027654-k0uby99n	154	27	for	for	IN
cord-027654-k0uby99n	154	28	human	human	JJ
cord-027654-k0uby99n	154	29	studies	study	NNS
cord-027654-k0uby99n	154	30	.	.	.
cord-027654-k0uby99n	155	1	In	in	IN
cord-027654-k0uby99n	155	2	part	part	NN
cord-027654-k0uby99n	155	3	this	this	DT
cord-027654-k0uby99n	155	4	may	may	MD
cord-027654-k0uby99n	155	5	be	be	VB
cord-027654-k0uby99n	155	6	due	due	JJ
cord-027654-k0uby99n	155	7	to	to	IN
cord-027654-k0uby99n	155	8	the	the	DT
cord-027654-k0uby99n	155	9	fact	fact	NN
cord-027654-k0uby99n	155	10	that	that	IN
cord-027654-k0uby99n	155	11	recombinant	recombinant	JJ
cord-027654-k0uby99n	155	12	transgenes	transgene	NNS
cord-027654-k0uby99n	155	13	represent	represent	VBP
cord-027654-k0uby99n	155	14	a	a	DT
cord-027654-k0uby99n	155	15	small	small	JJ
cord-027654-k0uby99n	155	16	minority	minority	NN
cord-027654-k0uby99n	155	17	of	of	IN
cord-027654-k0uby99n	155	18	gene	gene	NN
cord-027654-k0uby99n	155	19	products	product	NNS
cord-027654-k0uby99n	155	20	expressed	express	VBN
cord-027654-k0uby99n	155	21	in	in	IN
cord-027654-k0uby99n	155	22	this	this	DT
cord-027654-k0uby99n	155	23	otherwise	otherwise	RB
cord-027654-k0uby99n	155	24	large	large	JJ
cord-027654-k0uby99n	155	25	vector	vector	NN
cord-027654-k0uby99n	155	26	.	.	.
cord-027654-k0uby99n	156	1	Thus	thus	RB
cord-027654-k0uby99n	156	2	,	,	,
cord-027654-k0uby99n	156	3	there	there	EX
cord-027654-k0uby99n	156	4	is	be	VBZ
cord-027654-k0uby99n	156	5	no	no	DT
cord-027654-k0uby99n	156	6	certainty	certainty	NN
cord-027654-k0uby99n	156	7	that	that	IN
cord-027654-k0uby99n	156	8	the	the	DT
cord-027654-k0uby99n	156	9	immune	immune	JJ
cord-027654-k0uby99n	156	10	response	response	NN
cord-027654-k0uby99n	156	11	will	will	MD
cord-027654-k0uby99n	156	12	be	be	VB
cord-027654-k0uby99n	156	13	focused	focus	VBN
cord-027654-k0uby99n	156	14	to	to	IN
cord-027654-k0uby99n	156	15	the	the	DT
cord-027654-k0uby99n	156	16	foreign	foreign	JJ
cord-027654-k0uby99n	156	17	transgene	transgene	NN
cord-027654-k0uby99n	156	18	rather	rather	RB
cord-027654-k0uby99n	156	19	than	than	IN
cord-027654-k0uby99n	156	20	to	to	IN
cord-027654-k0uby99n	156	21	gene	gene	NN
cord-027654-k0uby99n	156	22	products	product	NNS
cord-027654-k0uby99n	156	23	synthesized	synthesize	VBN
cord-027654-k0uby99n	156	24	endogenously	endogenously	RB
cord-027654-k0uby99n	156	25	by	by	IN
cord-027654-k0uby99n	156	26	the	the	DT
cord-027654-k0uby99n	156	27	poxvirus	poxvirus	NNP
cord-027654-k0uby99n	156	28	.	.	.
cord-027654-k0uby99n	157	1	In	in	IN
cord-027654-k0uby99n	157	2	addition	addition	NN
cord-027654-k0uby99n	157	3	,	,	,
cord-027654-k0uby99n	157	4	similar	similar	JJ
cord-027654-k0uby99n	157	5	to	to	IN
cord-027654-k0uby99n	157	6	rAd	rAd	NNP
cord-027654-k0uby99n	157	7	,	,	,
cord-027654-k0uby99n	157	8	the	the	DT
cord-027654-k0uby99n	157	9	concern	concern	NN
cord-027654-k0uby99n	157	10	of	of	IN
cord-027654-k0uby99n	157	11	antivector	antivector	JJ
cord-027654-k0uby99n	157	12	immunity	immunity	NN
cord-027654-k0uby99n	157	13	remains	remain	VBZ
cord-027654-k0uby99n	157	14	for	for	IN
cord-027654-k0uby99n	157	15	this	this	DT
cord-027654-k0uby99n	157	16	virus	virus	NN
cord-027654-k0uby99n	157	17	as	as	RB
cord-027654-k0uby99n	157	18	well	well	RB
cord-027654-k0uby99n	157	19	,	,	,
cord-027654-k0uby99n	157	20	though	though	IN
cord-027654-k0uby99n	157	21	it	-PRON-	PRP
cord-027654-k0uby99n	157	22	may	may	MD
cord-027654-k0uby99n	157	23	be	be	VB
cord-027654-k0uby99n	157	24	a	a	DT
cord-027654-k0uby99n	157	25	lesser	less	JJR
cord-027654-k0uby99n	157	26	concern	concern	NN
cord-027654-k0uby99n	157	27	for	for	IN
cord-027654-k0uby99n	157	28	canarypox	canarypox	NN
cord-027654-k0uby99n	157	29	vectors	vector	NNS
cord-027654-k0uby99n	157	30	.	.	.
cord-027654-k0uby99n	158	1	Although	although	IN
cord-027654-k0uby99n	158	2	poxvirus	poxvirus	NNP
cord-027654-k0uby99n	158	3	vectors	vector	NNS
cord-027654-k0uby99n	158	4	show	show	VBP
cord-027654-k0uby99n	158	5	thermostability	thermostability	NN
cord-027654-k0uby99n	158	6	,	,	,
cord-027654-k0uby99n	158	7	ability	ability	NN
cord-027654-k0uby99n	158	8	to	to	TO
cord-027654-k0uby99n	158	9	incorporate	incorporate	VB
cord-027654-k0uby99n	158	10	a	a	DT
cord-027654-k0uby99n	158	11	large	large	JJ
cord-027654-k0uby99n	158	12	foreign	foreign	JJ
cord-027654-k0uby99n	158	13	transgene	transgene	NN
cord-027654-k0uby99n	158	14	,	,	,
cord-027654-k0uby99n	158	15	a	a	DT
cord-027654-k0uby99n	158	16	lack	lack	NN
cord-027654-k0uby99n	158	17	of	of	IN
cord-027654-k0uby99n	158	18	persistence	persistence	NN
cord-027654-k0uby99n	158	19	or	or	CC
cord-027654-k0uby99n	158	20	genomic	genomic	JJ
cord-027654-k0uby99n	158	21	integration	integration	NN
cord-027654-k0uby99n	158	22	,	,	,
cord-027654-k0uby99n	158	23	and	and	CC
cord-027654-k0uby99n	158	24	success	success	NN
cord-027654-k0uby99n	158	25	in	in	IN
cord-027654-k0uby99n	158	26	smallpox	smallpox	NN
cord-027654-k0uby99n	158	27	eradication	eradication	NN
cord-027654-k0uby99n	158	28	,	,	,
cord-027654-k0uby99n	158	29	the	the	DT
cord-027654-k0uby99n	158	30	diffi	diffi	NNP
cord-027654-k0uby99n	158	31	culties	cultie	NNS
cord-027654-k0uby99n	158	32	in	in	IN
cord-027654-k0uby99n	158	33	manufacturing	manufacture	VBG
cord-027654-k0uby99n	158	34	virus	virus	NN
cord-027654-k0uby99n	158	35	in	in	IN
cord-027654-k0uby99n	158	36	high	high	JJ
cord-027654-k0uby99n	158	37	yields	yield	NNS
cord-027654-k0uby99n	158	38	from	from	IN
cord-027654-k0uby99n	158	39	primary	primary	JJ
cord-027654-k0uby99n	158	40	chicken	chicken	NN
cord-027654-k0uby99n	158	41	embryo	embryo	NN
cord-027654-k0uby99n	158	42	fi	fi	NN
cord-027654-k0uby99n	158	43	broblast	broblast	NN
cord-027654-k0uby99n	158	44	cells	cell	NNS
cord-027654-k0uby99n	158	45	,	,	,
cord-027654-k0uby99n	158	46	as	as	RB
cord-027654-k0uby99n	158	47	well	well	RB
cord-027654-k0uby99n	158	48	as	as	IN
cord-027654-k0uby99n	158	49	their	-PRON-	PRP$
cord-027654-k0uby99n	158	50	antigenic	antigenic	JJ
cord-027654-k0uby99n	158	51	complexity	complexity	NN
cord-027654-k0uby99n	158	52	,	,	,
cord-027654-k0uby99n	158	53	reactogenicity	reactogenicity	NN
cord-027654-k0uby99n	158	54	and	and	CC
cord-027654-k0uby99n	158	55	poor	poor	JJ
cord-027654-k0uby99n	158	56	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	158	57	has	have	VBZ
cord-027654-k0uby99n	158	58	limited	limit	VBN
cord-027654-k0uby99n	158	59	their	-PRON-	PRP$
cord-027654-k0uby99n	158	60	utility	utility	NN
cord-027654-k0uby99n	158	61	in	in	IN
cord-027654-k0uby99n	158	62	human	human	JJ
cord-027654-k0uby99n	158	63	trials	trial	NNS
cord-027654-k0uby99n	158	64	.	.	.
cord-027654-k0uby99n	159	1	Whether	whether	IN
cord-027654-k0uby99n	159	2	additional	additional	JJ
cord-027654-k0uby99n	159	3	modifi	modifi	JJ
cord-027654-k0uby99n	159	4	cations	cation	NNS
cord-027654-k0uby99n	159	5	of	of	IN
cord-027654-k0uby99n	159	6	these	these	DT
cord-027654-k0uby99n	159	7	vectors	vector	NNS
cord-027654-k0uby99n	159	8	can	can	MD
cord-027654-k0uby99n	159	9	be	be	VB
cord-027654-k0uby99n	159	10	made	make	VBN
cord-027654-k0uby99n	159	11	to	to	TO
cord-027654-k0uby99n	159	12	facilitate	facilitate	VB
cord-027654-k0uby99n	159	13	human	human	JJ
cord-027654-k0uby99n	159	14	trials	trial	NNS
cord-027654-k0uby99n	159	15	remains	remain	VBZ
cord-027654-k0uby99n	159	16	unknown	unknown	JJ
cord-027654-k0uby99n	159	17	.	.	.
cord-027654-k0uby99n	160	1	If	if	IN
cord-027654-k0uby99n	160	2	such	such	JJ
cord-027654-k0uby99n	160	3	modifi	modifi	JJ
cord-027654-k0uby99n	160	4	cations	cation	NNS
cord-027654-k0uby99n	160	5	of	of	IN
cord-027654-k0uby99n	160	6	the	the	DT
cord-027654-k0uby99n	160	7	vector	vector	NN
cord-027654-k0uby99n	160	8	platform	platform	NN
cord-027654-k0uby99n	160	9	can	can	MD
cord-027654-k0uby99n	160	10	be	be	VB
cord-027654-k0uby99n	160	11	achieved	achieve	VBN
cord-027654-k0uby99n	160	12	,	,	,
cord-027654-k0uby99n	160	13	this	this	DT
cord-027654-k0uby99n	160	14	vector	vector	NN
cord-027654-k0uby99n	160	15	may	may	MD
cord-027654-k0uby99n	160	16	have	have	VB
cord-027654-k0uby99n	160	17	an	an	DT
cord-027654-k0uby99n	160	18	opportunity	opportunity	NN
cord-027654-k0uby99n	160	19	to	to	TO
cord-027654-k0uby99n	160	20	contribute	contribute	VB
cord-027654-k0uby99n	160	21	to	to	IN
cord-027654-k0uby99n	160	22	the	the	DT
cord-027654-k0uby99n	160	23	development	development	NN
cord-027654-k0uby99n	160	24	of	of	IN
cord-027654-k0uby99n	160	25	a	a	DT
cord-027654-k0uby99n	160	26	variety	variety	NN
cord-027654-k0uby99n	160	27	of	of	IN
cord-027654-k0uby99n	160	28	successful	successful	JJ
cord-027654-k0uby99n	160	29	vaccines	vaccine	NNS
cord-027654-k0uby99n	160	30	.	.	.
cord-027654-k0uby99n	161	1	The	the	DT
cord-027654-k0uby99n	161	2	adeno	adeno	NN
cord-027654-k0uby99n	161	3	-	-	HYPH
cord-027654-k0uby99n	161	4	associated	associate	VBN
cord-027654-k0uby99n	161	5	viruses	virus	NNS
cord-027654-k0uby99n	161	6	were	be	VBD
cord-027654-k0uby99n	161	7	defi	defi	NNP
cord-027654-k0uby99n	161	8	ned	ned	NNP
cord-027654-k0uby99n	161	9	initially	initially	RB
cord-027654-k0uby99n	161	10	by	by	IN
cord-027654-k0uby99n	161	11	their	-PRON-	PRP$
cord-027654-k0uby99n	161	12	presence	presence	NN
cord-027654-k0uby99n	161	13	as	as	IN
cord-027654-k0uby99n	161	14	'	'	``
cord-027654-k0uby99n	161	15	helper	helper	NN
cord-027654-k0uby99n	161	16	'	'	''
cord-027654-k0uby99n	161	17	viruses	virus	NNS
cord-027654-k0uby99n	161	18	that	that	WDT
cord-027654-k0uby99n	161	19	facilitated	facilitate	VBD
cord-027654-k0uby99n	161	20	the	the	DT
cord-027654-k0uby99n	161	21	propagation	propagation	NN
cord-027654-k0uby99n	161	22	of	of	IN
cord-027654-k0uby99n	161	23	wild	wild	JJ
cord-027654-k0uby99n	161	24	-	-	HYPH
cord-027654-k0uby99n	161	25	type	type	NN
cord-027654-k0uby99n	161	26	adenovirus	adenovirus	NN
cord-027654-k0uby99n	161	27	in	in	IN
cord-027654-k0uby99n	161	28	cell	cell	NN
cord-027654-k0uby99n	161	29	culture	culture	NN
cord-027654-k0uby99n	161	30	.	.	.
cord-027654-k0uby99n	162	1	In	in	IN
cord-027654-k0uby99n	162	2	contrast	contrast	NN
cord-027654-k0uby99n	162	3	to	to	IN
cord-027654-k0uby99n	162	4	the	the	DT
cord-027654-k0uby99n	162	5	large	large	JJ
cord-027654-k0uby99n	162	6	genome	genome	NN
cord-027654-k0uby99n	162	7	sizes	size	NNS
cord-027654-k0uby99n	162	8	of	of	IN
cord-027654-k0uby99n	162	9	rAd	rAd	NNS
cord-027654-k0uby99n	162	10	and	and	CC
cord-027654-k0uby99n	162	11	vaccinia	vaccinia	NN
cord-027654-k0uby99n	162	12	vectors	vector	NNS
cord-027654-k0uby99n	162	13	,	,	,
cord-027654-k0uby99n	162	14	this	this	DT
cord-027654-k0uby99n	162	15	virus	virus	NN
cord-027654-k0uby99n	162	16	is	be	VBZ
cord-027654-k0uby99n	162	17	much	much	RB
cord-027654-k0uby99n	162	18	more	more	RBR
cord-027654-k0uby99n	162	19	limited	limited	JJ
cord-027654-k0uby99n	162	20	in	in	IN
cord-027654-k0uby99n	162	21	size	size	NN
cord-027654-k0uby99n	162	22	,	,	,
cord-027654-k0uby99n	162	23	with	with	IN
cord-027654-k0uby99n	162	24	insert	insert	JJ
cord-027654-k0uby99n	162	25	size	size	NN
cord-027654-k0uby99n	162	26	of	of	IN
cord-027654-k0uby99n	162	27	approximately	approximately	RB
cord-027654-k0uby99n	162	28	5	5	CD
cord-027654-k0uby99n	162	29	kb	kb	NNS
cord-027654-k0uby99n	162	30	.	.	.
cord-027654-k0uby99n	163	1	Similar	similar	JJ
cord-027654-k0uby99n	163	2	to	to	IN
cord-027654-k0uby99n	163	3	other	other	JJ
cord-027654-k0uby99n	163	4	replication	replication	NN
cord-027654-k0uby99n	163	5	-	-	HYPH
cord-027654-k0uby99n	163	6	defective	defective	JJ
cord-027654-k0uby99n	163	7	viruses	virus	NNS
cord-027654-k0uby99n	163	8	,	,	,
cord-027654-k0uby99n	163	9	these	these	DT
cord-027654-k0uby99n	163	10	particles	particle	NNS
cord-027654-k0uby99n	163	11	can	can	MD
cord-027654-k0uby99n	163	12	be	be	VB
cord-027654-k0uby99n	163	13	produced	produce	VBN
cord-027654-k0uby99n	163	14	in	in	IN
cord-027654-k0uby99n	163	15	packaging	packaging	NN
cord-027654-k0uby99n	163	16	lines	line	NNS
cord-027654-k0uby99n	163	17	that	that	WDT
cord-027654-k0uby99n	163	18	provide	provide	VBP
cord-027654-k0uby99n	163	19	complementary	complementary	JJ
cord-027654-k0uby99n	163	20	structural	structural	JJ
cord-027654-k0uby99n	163	21	proteins	protein	NNS
cord-027654-k0uby99n	163	22	made	make	VBN
cord-027654-k0uby99n	163	23	constitutively	constitutively	RB
cord-027654-k0uby99n	163	24	by	by	IN
cord-027654-k0uby99n	163	25	the	the	DT
cord-027654-k0uby99n	163	26	cell	cell	NN
cord-027654-k0uby99n	163	27	rather	rather	RB
cord-027654-k0uby99n	163	28	than	than	IN
cord-027654-k0uby99n	163	29	the	the	DT
cord-027654-k0uby99n	163	30	virus	virus	NN
cord-027654-k0uby99n	163	31	.	.	.
cord-027654-k0uby99n	164	1	A	a	DT
cord-027654-k0uby99n	164	2	variety	variety	NN
cord-027654-k0uby99n	164	3	of	of	IN
cord-027654-k0uby99n	164	4	serotypes	serotype	NNS
cord-027654-k0uby99n	164	5	have	have	VBP
cord-027654-k0uby99n	164	6	been	be	VBN
cord-027654-k0uby99n	164	7	defi	defi	NNP
cord-027654-k0uby99n	164	8	ned	ned	NNP
cord-027654-k0uby99n	164	9	,	,	,
cord-027654-k0uby99n	164	10	102	102	CD
cord-027654-k0uby99n	164	11	and	and	CC
cord-027654-k0uby99n	164	12	an	an	DT
cord-027654-k0uby99n	164	13	HIV	HIV	NNP
cord-027654-k0uby99n	164	14	vaccine	vaccine	NN
cord-027654-k0uby99n	164	15	expressed	express	VBD
cord-027654-k0uby99n	164	16	in	in	IN
cord-027654-k0uby99n	164	17	AAV2	AAV2	NNP
cord-027654-k0uby99n	164	18	has	have	VBZ
cord-027654-k0uby99n	164	19	been	be	VBN
cord-027654-k0uby99n	164	20	analyzed	analyze	VBN
cord-027654-k0uby99n	164	21	in	in	IN
cord-027654-k0uby99n	164	22	Phase	phase	NN
cord-027654-k0uby99n	164	23	I	i	CD
cord-027654-k0uby99n	164	24	human	human	JJ
cord-027654-k0uby99n	164	25	studies	study	NNS
cord-027654-k0uby99n	164	26	,	,	,
cord-027654-k0uby99n	164	27	without	without	IN
cord-027654-k0uby99n	164	28	evidence	evidence	NN
cord-027654-k0uby99n	164	29	of	of	IN
cord-027654-k0uby99n	164	30	strong	strong	JJ
cord-027654-k0uby99n	164	31	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	164	32	.	.	.
cord-027654-k0uby99n	165	1	Alternative	alternative	JJ
cord-027654-k0uby99n	165	2	serotypes	serotype	NNS
cord-027654-k0uby99n	165	3	,	,	,
cord-027654-k0uby99n	165	4	including	include	VBG
cord-027654-k0uby99n	165	5	AAV1	AAV1	NNP
cord-027654-k0uby99n	165	6	,	,	,
cord-027654-k0uby99n	165	7	are	be	VBP
cord-027654-k0uby99n	165	8	currently	currently	RB
cord-027654-k0uby99n	165	9	under	under	IN
cord-027654-k0uby99n	165	10	development	development	NN
cord-027654-k0uby99n	165	11	and	and	CC
cord-027654-k0uby99n	165	12	may	may	MD
cord-027654-k0uby99n	165	13	be	be	VB
cord-027654-k0uby99n	165	14	assessed	assess	VBN
cord-027654-k0uby99n	165	15	both	both	CC
cord-027654-k0uby99n	165	16	alone	alone	JJ
cord-027654-k0uby99n	165	17	and	and	CC
cord-027654-k0uby99n	165	18	in	in	IN
cord-027654-k0uby99n	165	19	primeboost	primeboost	JJ
cord-027654-k0uby99n	165	20	combinations	combination	NNS
cord-027654-k0uby99n	165	21	for	for	IN
cord-027654-k0uby99n	165	22	effi	effi	NNP
cord-027654-k0uby99n	165	23	cacy	cacy	NNP
cord-027654-k0uby99n	165	24	in	in	IN
cord-027654-k0uby99n	165	25	humans	human	NNS
cord-027654-k0uby99n	165	26	.	.	.
cord-027654-k0uby99n	166	1	The	the	DT
cord-027654-k0uby99n	166	2	alphaviruses	alphavirus	NNS
cord-027654-k0uby99n	166	3	represent	represent	VBP
cord-027654-k0uby99n	166	4	negative	negative	JJ
cord-027654-k0uby99n	166	5	-	-	HYPH
cord-027654-k0uby99n	166	6	stranded	strand	VBN
cord-027654-k0uby99n	166	7	RNA	RNA	NNP
cord-027654-k0uby99n	166	8	viruses	virus	NNS
cord-027654-k0uby99n	166	9	that	that	WDT
cord-027654-k0uby99n	166	10	can	can	MD
cord-027654-k0uby99n	166	11	be	be	VB
cord-027654-k0uby99n	166	12	modifi	modifi	JJ
cord-027654-k0uby99n	166	13	ed	ed	NN
cord-027654-k0uby99n	166	14	to	to	TO
cord-027654-k0uby99n	166	15	express	express	VB
cord-027654-k0uby99n	166	16	foreign	foreign	JJ
cord-027654-k0uby99n	166	17	recombinant	recombinant	JJ
cord-027654-k0uby99n	166	18	genes	gene	NNS
cord-027654-k0uby99n	166	19	rather	rather	RB
cord-027654-k0uby99n	166	20	than	than	IN
cord-027654-k0uby99n	166	21	produce	produce	VB
cord-027654-k0uby99n	166	22	pathogenic	pathogenic	JJ
cord-027654-k0uby99n	166	23	infections	infection	NNS
cord-027654-k0uby99n	166	24	often	often	RB
cord-027654-k0uby99n	166	25	seen	see	VBN
cord-027654-k0uby99n	166	26	with	with	IN
cord-027654-k0uby99n	166	27	prototypes	prototype	NNS
cord-027654-k0uby99n	166	28	such	such	JJ
cord-027654-k0uby99n	166	29	as	as	IN
cord-027654-k0uby99n	166	30	Venezuelan	venezuelan	JJ
cord-027654-k0uby99n	166	31	equine	equine	NN
cord-027654-k0uby99n	166	32	encephalitis	encephalitis	NN
cord-027654-k0uby99n	166	33	virus	virus	NN
cord-027654-k0uby99n	166	34	(	(	-LRB-
cord-027654-k0uby99n	166	35	VEE	VEE	NNP
cord-027654-k0uby99n	166	36	)	)	-RRB-
cord-027654-k0uby99n	166	37	,	,	,
cord-027654-k0uby99n	166	38	103	103	CD
cord-027654-k0uby99n	166	39	,	,	,
cord-027654-k0uby99n	166	40	104	104	CD
cord-027654-k0uby99n	166	41	Sindbis	Sindbis	NNP
cord-027654-k0uby99n	166	42	virus	virus	NN
cord-027654-k0uby99n	166	43	105	105	CD
cord-027654-k0uby99n	166	44	,	,	,
cord-027654-k0uby99n	166	45	106	106	CD
cord-027654-k0uby99n	166	46	and	and	CC
cord-027654-k0uby99n	166	47	Semliki	Semliki	NNP
cord-027654-k0uby99n	166	48	Forest	Forest	NNP
cord-027654-k0uby99n	166	49	virus	virus	NN
cord-027654-k0uby99n	166	50	(	(	-LRB-
cord-027654-k0uby99n	166	51	SFV	SFV	NNP
cord-027654-k0uby99n	166	52	)	)	-RRB-
cord-027654-k0uby99n	166	53	.	.	.
cord-027654-k0uby99n	167	1	Replication	replication	NN
cord-027654-k0uby99n	167	2	-	-	HYPH
cord-027654-k0uby99n	167	3	defective	defective	JJ
cord-027654-k0uby99n	167	4	HSV	HSV	NNP
cord-027654-k0uby99n	167	5	can	can	MD
cord-027654-k0uby99n	167	6	be	be	VB
cord-027654-k0uby99n	167	7	produced	produce	VBN
cord-027654-k0uby99n	167	8	using	use	VBG
cord-027654-k0uby99n	167	9	packaging	packaging	NN
cord-027654-k0uby99n	167	10	cell	cell	NN
cord-027654-k0uby99n	167	11	lines	line	NNS
cord-027654-k0uby99n	167	12	similar	similar	JJ
cord-027654-k0uby99n	167	13	to	to	IN
cord-027654-k0uby99n	167	14	those	those	DT
cord-027654-k0uby99n	167	15	described	describe	VBN
cord-027654-k0uby99n	167	16	for	for	IN
cord-027654-k0uby99n	167	17	replication	replication	NN
cord-027654-k0uby99n	167	18	-	-	HYPH
cord-027654-k0uby99n	167	19	defective	defective	JJ
cord-027654-k0uby99n	167	20	rAd5	rAd5	NNP
cord-027654-k0uby99n	167	21	,	,	,
cord-027654-k0uby99n	167	22	AAV	AAV	NNP
cord-027654-k0uby99n	167	23	,	,	,
cord-027654-k0uby99n	167	24	or	or	CC
cord-027654-k0uby99n	167	25	alphavirus	alphavirus	NNP
cord-027654-k0uby99n	167	26	vectors	vector	NNS
cord-027654-k0uby99n	167	27	.	.	.
cord-027654-k0uby99n	168	1	These	these	DT
cord-027654-k0uby99n	168	2	vaccines	vaccine	NNS
cord-027654-k0uby99n	168	3	have	have	VBP
cord-027654-k0uby99n	168	4	been	be	VBN
cord-027654-k0uby99n	168	5	developed	develop	VBN
cord-027654-k0uby99n	168	6	not	not	RB
cord-027654-k0uby99n	168	7	only	only	RB
cord-027654-k0uby99n	168	8	to	to	TO
cord-027654-k0uby99n	168	9	deliver	deliver	VB
cord-027654-k0uby99n	168	10	foreign	foreign	JJ
cord-027654-k0uby99n	168	11	genes	gene	NNS
cord-027654-k0uby99n	168	12	as	as	IN
cord-027654-k0uby99n	168	13	potential	potential	JJ
cord-027654-k0uby99n	168	14	immunogens	immunogen	NNS
cord-027654-k0uby99n	168	15	but	but	CC
cord-027654-k0uby99n	168	16	also	also	RB
cord-027654-k0uby99n	168	17	as	as	IN
cord-027654-k0uby99n	168	18	vectors	vector	NNS
cord-027654-k0uby99n	168	19	against	against	IN
cord-027654-k0uby99n	168	20	HSV	HSV	NNP
cord-027654-k0uby99n	168	21	itself	-PRON-	PRP
cord-027654-k0uby99n	168	22	,	,	,
cord-027654-k0uby99n	168	23	including	include	VBG
cord-027654-k0uby99n	168	24	both	both	CC
cord-027654-k0uby99n	168	25	HSV1	HSV1	NNP
cord-027654-k0uby99n	168	26	and	and	CC
cord-027654-k0uby99n	168	27	HSV2	HSV2	NNP
cord-027654-k0uby99n	168	28	.	.	.
cord-027654-k0uby99n	169	1	107	107	CD
cord-027654-k0uby99n	170	1	More	more	RBR
cord-027654-k0uby99n	170	2	recently	recently	RB
cord-027654-k0uby99n	170	3	,	,	,
cord-027654-k0uby99n	170	4	vesicular	vesicular	JJ
cord-027654-k0uby99n	170	5	stomatitis	stomatitis	NN
cord-027654-k0uby99n	170	6	virus	virus	NN
cord-027654-k0uby99n	170	7	,	,	,
cord-027654-k0uby99n	170	8	dengue	dengue	NN
cord-027654-k0uby99n	170	9	virus	virus	NN
cord-027654-k0uby99n	170	10	type	type	NN
cord-027654-k0uby99n	170	11	4	4	CD
cord-027654-k0uby99n	170	12	,	,	,
cord-027654-k0uby99n	170	13	and	and	CC
cord-027654-k0uby99n	170	14	yellow	yellow	JJ
cord-027654-k0uby99n	170	15	fever	fever	NN
cord-027654-k0uby99n	170	16	virus	virus	NN
cord-027654-k0uby99n	170	17	have	have	VBP
cord-027654-k0uby99n	170	18	been	be	VBN
cord-027654-k0uby99n	170	19	modifi	modifi	JJ
cord-027654-k0uby99n	170	20	ed	ed	NN
cord-027654-k0uby99n	170	21	to	to	TO
cord-027654-k0uby99n	170	22	express	express	VB
cord-027654-k0uby99n	170	23	heterologous	heterologous	JJ
cord-027654-k0uby99n	170	24	viral	viral	JJ
cord-027654-k0uby99n	170	25	genes	gene	NNS
cord-027654-k0uby99n	170	26	for	for	IN
cord-027654-k0uby99n	170	27	vaccines	vaccine	NNS
cord-027654-k0uby99n	170	28	for	for	IN
cord-027654-k0uby99n	170	29	infectious	infectious	JJ
cord-027654-k0uby99n	170	30	disease	disease	NN
cord-027654-k0uby99n	170	31	targets	target	NNS
cord-027654-k0uby99n	170	32	including	include	VBG
cord-027654-k0uby99n	170	33	HIV	HIV	NNP
cord-027654-k0uby99n	170	34	,	,	,
cord-027654-k0uby99n	170	35	West	West	NNP
cord-027654-k0uby99n	170	36	Nile	Nile	NNP
cord-027654-k0uby99n	170	37	virus	virus	NN
cord-027654-k0uby99n	170	38	,	,	,
cord-027654-k0uby99n	170	39	fi	fi	NNP
cord-027654-k0uby99n	170	40	loviruses	loviruses	NNP
cord-027654-k0uby99n	170	41	and	and	CC
cord-027654-k0uby99n	170	42	other	other	JJ
cord-027654-k0uby99n	170	43	pathogens	pathogen	NNS
cord-027654-k0uby99n	170	44	.	.	.
cord-027654-k0uby99n	171	1	[	[	-LRB-
cord-027654-k0uby99n	171	2	108	108	CD
cord-027654-k0uby99n	171	3	]	]	-RRB-
cord-027654-k0uby99n	171	4	[	[	-LRB-
cord-027654-k0uby99n	171	5	109	109	CD
cord-027654-k0uby99n	171	6	]	]	-RRB-
cord-027654-k0uby99n	171	7	[	[	-LRB-
cord-027654-k0uby99n	171	8	110	110	CD
cord-027654-k0uby99n	171	9	]	]	-RRB-
cord-027654-k0uby99n	171	10	[	[	-LRB-
cord-027654-k0uby99n	171	11	111	111	CD
cord-027654-k0uby99n	171	12	]	]	-RRB-
cord-027654-k0uby99n	171	13	[	[	-LRB-
cord-027654-k0uby99n	171	14	112	112	CD
cord-027654-k0uby99n	171	15	]	]	-RRB-
cord-027654-k0uby99n	171	16	[	[	-LRB-
cord-027654-k0uby99n	171	17	113	113	CD
cord-027654-k0uby99n	171	18	]	]	-RRB-
cord-027654-k0uby99n	171	19	[	[	-LRB-
cord-027654-k0uby99n	171	20	114	114	CD
cord-027654-k0uby99n	171	21	]	]	-RRB-
cord-027654-k0uby99n	172	1	Cell	cell	NN
cord-027654-k0uby99n	172	2	substrates	substrate	NNS
cord-027654-k0uby99n	173	1	The	the	DT
cord-027654-k0uby99n	173	2	progress	progress	NN
cord-027654-k0uby99n	173	3	of	of	IN
cord-027654-k0uby99n	173	4	more	more	RBR
cord-027654-k0uby99n	173	5	recent	recent	JJ
cord-027654-k0uby99n	173	6	viral	viral	JJ
cord-027654-k0uby99n	173	7	vectors	vector	NNS
cord-027654-k0uby99n	173	8	has	have	VBZ
cord-027654-k0uby99n	173	9	been	be	VBN
cord-027654-k0uby99n	173	10	dependent	dependent	JJ
cord-027654-k0uby99n	173	11	upon	upon	IN
cord-027654-k0uby99n	173	12	the	the	DT
cord-027654-k0uby99n	173	13	development	development	NN
cord-027654-k0uby99n	173	14	of	of	IN
cord-027654-k0uby99n	173	15	appropriate	appropriate	JJ
cord-027654-k0uby99n	173	16	packaging	packaging	NN
cord-027654-k0uby99n	173	17	cell	cell	NN
cord-027654-k0uby99n	173	18	lines	line	NNS
cord-027654-k0uby99n	173	19	and	and	CC
cord-027654-k0uby99n	173	20	cell	cell	NN
cord-027654-k0uby99n	173	21	substrates	substrate	NNS
cord-027654-k0uby99n	173	22	for	for	IN
cord-027654-k0uby99n	173	23	viral	viral	JJ
cord-027654-k0uby99n	173	24	production	production	NN
cord-027654-k0uby99n	173	25	.	.	.
cord-027654-k0uby99n	174	1	Changes	change	NNS
cord-027654-k0uby99n	174	2	in	in	IN
cord-027654-k0uby99n	174	3	regulatory	regulatory	JJ
cord-027654-k0uby99n	174	4	requirements	requirement	NNS
cord-027654-k0uby99n	174	5	that	that	WDT
cord-027654-k0uby99n	174	6	allowed	allow	VBD
cord-027654-k0uby99n	174	7	the	the	DT
cord-027654-k0uby99n	174	8	advancement	advancement	NN
cord-027654-k0uby99n	174	9	of	of	IN
cord-027654-k0uby99n	174	10	transformed	transformed	JJ
cord-027654-k0uby99n	174	11	cell	cell	NN
cord-027654-k0uby99n	174	12	lines	line	NNS
cord-027654-k0uby99n	174	13	for	for	IN
cord-027654-k0uby99n	174	14	virus	virus	NN
cord-027654-k0uby99n	174	15	production	production	NN
cord-027654-k0uby99n	174	16	have	have	VBP
cord-027654-k0uby99n	174	17	proven	prove	VBN
cord-027654-k0uby99n	174	18	invaluable	invaluable	JJ
cord-027654-k0uby99n	174	19	in	in	IN
cord-027654-k0uby99n	174	20	facilitating	facilitate	VBG
cord-027654-k0uby99n	174	21	this	this	DT
cord-027654-k0uby99n	174	22	effort	effort	NN
cord-027654-k0uby99n	174	23	.	.	.
cord-027654-k0uby99n	175	1	For	for	IN
cord-027654-k0uby99n	175	2	recombinant	recombinant	JJ
cord-027654-k0uby99n	175	3	adenoviral	adenoviral	JJ
cord-027654-k0uby99n	175	4	production	production	NN
cord-027654-k0uby99n	175	5	,	,	,
cord-027654-k0uby99n	175	6	the	the	DT
cord-027654-k0uby99n	175	7	PERC6	perc6	NN
cord-027654-k0uby99n	175	8	and	and	CC
cord-027654-k0uby99n	175	9	GV11	GV11	NNP
cord-027654-k0uby99n	175	10	cell	cell	NN
cord-027654-k0uby99n	175	11	lines	line	NNS
cord-027654-k0uby99n	175	12	have	have	VBP
cord-027654-k0uby99n	175	13	supported	support	VBN
cord-027654-k0uby99n	175	14	production	production	NN
cord-027654-k0uby99n	175	15	of	of	IN
cord-027654-k0uby99n	175	16	clinical	clinical	JJ
cord-027654-k0uby99n	175	17	-	-	HYPH
cord-027654-k0uby99n	175	18	grade	grade	NN
cord-027654-k0uby99n	175	19	adenovirus	adenovirus	NN
cord-027654-k0uby99n	175	20	type	type	NN
cord-027654-k0uby99n	175	21	5	5	CD
cord-027654-k0uby99n	175	22	that	that	WDT
cord-027654-k0uby99n	175	23	have	have	VBP
cord-027654-k0uby99n	175	24	progressed	progress	VBN
cord-027654-k0uby99n	175	25	into	into	IN
cord-027654-k0uby99n	175	26	trials	trial	NNS
cord-027654-k0uby99n	175	27	for	for	IN
cord-027654-k0uby99n	175	28	HIV	HIV	NNP
cord-027654-k0uby99n	175	29	,	,	,
cord-027654-k0uby99n	175	30	Ebola	Ebola	NNP
cord-027654-k0uby99n	175	31	virus	virus	NN
cord-027654-k0uby99n	175	32	and	and	CC
cord-027654-k0uby99n	175	33	malaria	malaria	NN
cord-027654-k0uby99n	175	34	,	,	,
cord-027654-k0uby99n	175	35	and	and	CC
cord-027654-k0uby99n	175	36	are	be	VBP
cord-027654-k0uby99n	175	37	under	under	IN
cord-027654-k0uby99n	175	38	study	study	NN
cord-027654-k0uby99n	175	39	for	for	IN
cord-027654-k0uby99n	175	40	other	other	JJ
cord-027654-k0uby99n	175	41	infectious	infectious	JJ
cord-027654-k0uby99n	175	42	agents	agent	NNS
cord-027654-k0uby99n	175	43	,	,	,
cord-027654-k0uby99n	175	44	such	such	JJ
cord-027654-k0uby99n	175	45	as	as	IN
cord-027654-k0uby99n	175	46	Marburg	Marburg	NNP
cord-027654-k0uby99n	175	47	virus	virus	NN
cord-027654-k0uby99n	175	48	and	and	CC
cord-027654-k0uby99n	175	49	tuberculosis	tuberculosis	NN
cord-027654-k0uby99n	175	50	.	.	.
cord-027654-k0uby99n	176	1	Once	once	IN
cord-027654-k0uby99n	176	2	approved	approve	VBN
cord-027654-k0uby99n	176	3	,	,	,
cord-027654-k0uby99n	176	4	these	these	DT
cord-027654-k0uby99n	176	5	cell	cell	NN
cord-027654-k0uby99n	176	6	lines	line	NNS
cord-027654-k0uby99n	176	7	can	can	MD
cord-027654-k0uby99n	176	8	be	be	VB
cord-027654-k0uby99n	176	9	used	use	VBN
cord-027654-k0uby99n	176	10	for	for	IN
cord-027654-k0uby99n	176	11	diverse	diverse	JJ
cord-027654-k0uby99n	176	12	vectors	vector	NNS
cord-027654-k0uby99n	176	13	,	,	,
cord-027654-k0uby99n	176	14	and	and	CC
cord-027654-k0uby99n	176	15	the	the	DT
cord-027654-k0uby99n	176	16	PERC6	perc6	JJ
cord-027654-k0uby99n	176	17	cell	cell	NN
cord-027654-k0uby99n	176	18	line	line	NN
cord-027654-k0uby99n	176	19	has	have	VBZ
cord-027654-k0uby99n	176	20	now	now	RB
cord-027654-k0uby99n	176	21	been	be	VBN
cord-027654-k0uby99n	176	22	used	use	VBN
cord-027654-k0uby99n	176	23	to	to	TO
cord-027654-k0uby99n	176	24	develop	develop	VB
cord-027654-k0uby99n	176	25	a	a	DT
cord-027654-k0uby99n	176	26	number	number	NN
cord-027654-k0uby99n	176	27	of	of	IN
cord-027654-k0uby99n	176	28	vaccines	vaccine	NNS
cord-027654-k0uby99n	176	29	,	,	,
cord-027654-k0uby99n	176	30	including	include	VBG
cord-027654-k0uby99n	176	31	those	those	DT
cord-027654-k0uby99n	176	32	for	for	IN
cord-027654-k0uby99n	176	33	West	West	NNP
cord-027654-k0uby99n	176	34	Nile	Nile	NNP
cord-027654-k0uby99n	176	35	and	and	CC
cord-027654-k0uby99n	176	36	infl	infl	NNP
cord-027654-k0uby99n	176	37	uenza	uenza	NN
cord-027654-k0uby99n	176	38	viruses	virus	NNS
cord-027654-k0uby99n	176	39	.	.	.
cord-027654-k0uby99n	177	1	In	in	IN
cord-027654-k0uby99n	177	2	these	these	DT
cord-027654-k0uby99n	177	3	latter	latter	JJ
cord-027654-k0uby99n	177	4	cases	case	NNS
cord-027654-k0uby99n	177	5	,	,	,
cord-027654-k0uby99n	177	6	the	the	DT
cord-027654-k0uby99n	177	7	propagated	propagate	VBN
cord-027654-k0uby99n	177	8	virus	virus	NN
cord-027654-k0uby99n	177	9	is	be	VBZ
cord-027654-k0uby99n	177	10	subsequently	subsequently	RB
cord-027654-k0uby99n	177	11	inactivated	inactivate	VBN
cord-027654-k0uby99n	177	12	before	before	IN
cord-027654-k0uby99n	177	13	administration	administration	NN
cord-027654-k0uby99n	177	14	to	to	IN
cord-027654-k0uby99n	177	15	humans	human	NNS
cord-027654-k0uby99n	177	16	.	.	.
cord-027654-k0uby99n	178	1	For	for	IN
cord-027654-k0uby99n	178	2	the	the	DT
cord-027654-k0uby99n	178	3	generation	generation	NN
cord-027654-k0uby99n	178	4	of	of	IN
cord-027654-k0uby99n	178	5	replication	replication	NN
cord-027654-k0uby99n	178	6	-	-	HYPH
cord-027654-k0uby99n	178	7	defective	defective	JJ
cord-027654-k0uby99n	178	8	viral	viral	JJ
cord-027654-k0uby99n	178	9	vectors	vector	NNS
cord-027654-k0uby99n	178	10	,	,	,
cord-027654-k0uby99n	178	11	these	these	DT
cord-027654-k0uby99n	178	12	cell	cell	NN
cord-027654-k0uby99n	178	13	lines	line	NNS
cord-027654-k0uby99n	178	14	allow	allow	VBP
cord-027654-k0uby99n	178	15	the	the	DT
cord-027654-k0uby99n	178	16	production	production	NN
cord-027654-k0uby99n	178	17	of	of	IN
cord-027654-k0uby99n	178	18	vectors	vector	NNS
cord-027654-k0uby99n	178	19	that	that	WDT
cord-027654-k0uby99n	178	20	can	can	MD
cord-027654-k0uby99n	178	21	be	be	VB
cord-027654-k0uby99n	178	22	used	use	VBN
cord-027654-k0uby99n	178	23	in	in	IN
cord-027654-k0uby99n	178	24	human	human	JJ
cord-027654-k0uby99n	178	25	vaccine	vaccine	NN
cord-027654-k0uby99n	178	26	studies	study	NNS
cord-027654-k0uby99n	178	27	.	.	.
cord-027654-k0uby99n	179	1	Of	of	IN
cord-027654-k0uby99n	179	2	the	the	DT
cord-027654-k0uby99n	179	3	viruses	virus	NNS
cord-027654-k0uby99n	179	4	developed	develop	VBN
cord-027654-k0uby99n	179	5	for	for	IN
cord-027654-k0uby99n	179	6	such	such	JJ
cord-027654-k0uby99n	179	7	vaccines	vaccine	NNS
cord-027654-k0uby99n	179	8	,	,	,
cord-027654-k0uby99n	179	9	representative	representative	JJ
cord-027654-k0uby99n	179	10	members	member	NNS
cord-027654-k0uby99n	179	11	,	,	,
cord-027654-k0uby99n	179	12	summarized	summarize	VBN
cord-027654-k0uby99n	179	13	in	in	IN
cord-027654-k0uby99n	179	14	Figure	Figure	NNP
cord-027654-k0uby99n	179	15	62	62	CD
cord-027654-k0uby99n	179	16	-1B	-1B	NNP
cord-027654-k0uby99n	179	17	,	,	,
cord-027654-k0uby99n	179	18	include	include	VBP
cord-027654-k0uby99n	179	19	recombinant	recombinant	JJ
cord-027654-k0uby99n	179	20	Ad	ad	NN
cord-027654-k0uby99n	179	21	,	,	,
cord-027654-k0uby99n	179	22	poxviruses	poxvirus	NNS
cord-027654-k0uby99n	179	23	,	,	,
cord-027654-k0uby99n	179	24	measles	measle	NNS
cord-027654-k0uby99n	179	25	,	,	,
cord-027654-k0uby99n	179	26	Venezualan	Venezualan	NNP
cord-027654-k0uby99n	179	27	equine	equine	NN
cord-027654-k0uby99n	179	28	encephalitis	encephalitis	NN
cord-027654-k0uby99n	179	29	(	(	-LRB-
cord-027654-k0uby99n	179	30	VEE	VEE	NNP
cord-027654-k0uby99n	179	31	)	)	-RRB-
cord-027654-k0uby99n	179	32	virus	virus	NN
cord-027654-k0uby99n	179	33	and	and	CC
cord-027654-k0uby99n	179	34	AAV	AAV	NNP
cord-027654-k0uby99n	179	35	,	,	,
cord-027654-k0uby99n	179	36	all	all	DT
cord-027654-k0uby99n	179	37	of	of	IN
cord-027654-k0uby99n	179	38	which	which	WDT
cord-027654-k0uby99n	179	39	have	have	VBP
cord-027654-k0uby99n	179	40	progressed	progress	VBN
cord-027654-k0uby99n	179	41	into	into	IN
cord-027654-k0uby99n	179	42	human	human	JJ
cord-027654-k0uby99n	179	43	trials	trial	NNS
cord-027654-k0uby99n	179	44	.	.	.
cord-027654-k0uby99n	180	1	The	the	DT
cord-027654-k0uby99n	180	2	development	development	NN
cord-027654-k0uby99n	180	3	of	of	IN
cord-027654-k0uby99n	180	4	transformed	transform	VBN
cord-027654-k0uby99n	180	5	and	and	CC
cord-027654-k0uby99n	180	6	continuously	continuously	RB
cord-027654-k0uby99n	180	7	propagatable	propagatable	JJ
cord-027654-k0uby99n	180	8	cell	cell	NN
cord-027654-k0uby99n	180	9	lines	line	NNS
cord-027654-k0uby99n	180	10	,	,	,
cord-027654-k0uby99n	180	11	in	in	IN
cord-027654-k0uby99n	180	12	contrast	contrast	NN
cord-027654-k0uby99n	180	13	to	to	IN
cord-027654-k0uby99n	180	14	the	the	DT
cord-027654-k0uby99n	180	15	previous	previous	JJ
cord-027654-k0uby99n	180	16	standard	standard	NN
cord-027654-k0uby99n	180	17	,	,	,
cord-027654-k0uby99n	180	18	avian	avian	JJ
cord-027654-k0uby99n	180	19	leucosis	leucosis	NN
cord-027654-k0uby99n	180	20	free	free	NNP
cord-027654-k0uby99n	180	21	primary	primary	JJ
cord-027654-k0uby99n	180	22	chick	chick	NNP
cord-027654-k0uby99n	180	23	embryo	embryo	NN
cord-027654-k0uby99n	180	24	fi	fi	IN
cord-027654-k0uby99n	180	25	broblasts	broblasts	NNP
cord-027654-k0uby99n	180	26	,	,	,
cord-027654-k0uby99n	180	27	represents	represent	VBZ
cord-027654-k0uby99n	180	28	a	a	DT
cord-027654-k0uby99n	180	29	major	major	JJ
cord-027654-k0uby99n	180	30	advance	advance	NN
cord-027654-k0uby99n	180	31	in	in	IN
cord-027654-k0uby99n	180	32	vaccine	vaccine	NN
cord-027654-k0uby99n	180	33	production	production	NN
cord-027654-k0uby99n	180	34	technology	technology	NN
cord-027654-k0uby99n	180	35	,	,	,
cord-027654-k0uby99n	180	36	largely	largely	RB
cord-027654-k0uby99n	180	37	because	because	IN
cord-027654-k0uby99n	180	38	such	such	JJ
cord-027654-k0uby99n	180	39	cell	cell	NN
cord-027654-k0uby99n	180	40	lines	line	NNS
cord-027654-k0uby99n	180	41	facilitate	facilitate	VBP
cord-027654-k0uby99n	180	42	the	the	DT
cord-027654-k0uby99n	180	43	production	production	NN
cord-027654-k0uby99n	180	44	of	of	IN
cord-027654-k0uby99n	180	45	replication	replication	NN
cord-027654-k0uby99n	180	46	-	-	HYPH
cord-027654-k0uby99n	180	47	defective	defective	JJ
cord-027654-k0uby99n	180	48	viral	viral	JJ
cord-027654-k0uby99n	180	49	vectors	vector	NNS
cord-027654-k0uby99n	180	50	in	in	IN
cord-027654-k0uby99n	180	51	stably	stably	RB
cord-027654-k0uby99n	180	52	transfected	transfecte	VBN
cord-027654-k0uby99n	180	53	cell	cell	NN
cord-027654-k0uby99n	180	54	lines	line	NNS
cord-027654-k0uby99n	180	55	.	.	.
cord-027654-k0uby99n	181	1	Such	such	JJ
cord-027654-k0uby99n	181	2	lines	line	NNS
cord-027654-k0uby99n	181	3	also	also	RB
cord-027654-k0uby99n	181	4	offer	offer	VBP
cord-027654-k0uby99n	181	5	potentially	potentially	RB
cord-027654-k0uby99n	181	6	improved	improve	VBN
cord-027654-k0uby99n	181	7	yields	yield	NNS
cord-027654-k0uby99n	181	8	and	and	CC
cord-027654-k0uby99n	181	9	stable	stable	JJ
cord-027654-k0uby99n	181	10	production	production	NN
cord-027654-k0uby99n	181	11	capacity	capacity	NN
cord-027654-k0uby99n	181	12	.	.	.
cord-027654-k0uby99n	182	1	The	the	DT
cord-027654-k0uby99n	182	2	development	development	NN
cord-027654-k0uby99n	182	3	of	of	IN
cord-027654-k0uby99n	182	4	such	such	JJ
cord-027654-k0uby99n	182	5	lines	line	NNS
cord-027654-k0uby99n	182	6	has	have	VBZ
cord-027654-k0uby99n	182	7	taken	take	VBN
cord-027654-k0uby99n	182	8	years	year	NNS
cord-027654-k0uby99n	182	9	to	to	TO
cord-027654-k0uby99n	182	10	implement	implement	VB
cord-027654-k0uby99n	182	11	because	because	IN
cord-027654-k0uby99n	182	12	of	of	IN
cord-027654-k0uby99n	182	13	regulatory	regulatory	JJ
cord-027654-k0uby99n	182	14	concerns	concern	NNS
cord-027654-k0uby99n	182	15	regarding	regard	VBG
cord-027654-k0uby99n	182	16	adventitious	adventitious	JJ
cord-027654-k0uby99n	182	17	agents	agent	NNS
cord-027654-k0uby99n	182	18	,	,	,
cord-027654-k0uby99n	182	19	tumorigenicity	tumorigenicity	NN
cord-027654-k0uby99n	182	20	and	and	CC
cord-027654-k0uby99n	182	21	other	other	JJ
cord-027654-k0uby99n	182	22	safety	safety	NN
cord-027654-k0uby99n	182	23	/	/	SYM
cord-027654-k0uby99n	182	24	consistency	consistency	NN
cord-027654-k0uby99n	182	25	considerations	consideration	NNS
cord-027654-k0uby99n	182	26	.	.	.
cord-027654-k0uby99n	183	1	Such	such	JJ
cord-027654-k0uby99n	183	2	oversight	oversight	NN
cord-027654-k0uby99n	183	3	and	and	CC
cord-027654-k0uby99n	183	4	evaluation	evaluation	NN
cord-027654-k0uby99n	183	5	of	of	IN
cord-027654-k0uby99n	183	6	the	the	DT
cord-027654-k0uby99n	183	7	strengths	strength	NNS
cord-027654-k0uby99n	183	8	and	and	CC
cord-027654-k0uby99n	183	9	limitations	limitation	NNS
cord-027654-k0uby99n	183	10	of	of	IN
cord-027654-k0uby99n	183	11	these	these	DT
cord-027654-k0uby99n	183	12	cell	cell	NN
cord-027654-k0uby99n	183	13	substrates	substrate	NNS
cord-027654-k0uby99n	183	14	continues	continue	VBZ
cord-027654-k0uby99n	183	15	,	,	,
cord-027654-k0uby99n	183	16	115	115	CD
cord-027654-k0uby99n	183	17	based	base	VBN
cord-027654-k0uby99n	183	18	on	on	IN
cord-027654-k0uby99n	183	19	guidelines	guideline	NNS
cord-027654-k0uby99n	183	20	several	several	JJ
cord-027654-k0uby99n	183	21	years	year	NNS
cord-027654-k0uby99n	183	22	ago	ago	RB
cord-027654-k0uby99n	183	23	,	,	,
cord-027654-k0uby99n	183	24	116	116	CD
cord-027654-k0uby99n	183	25	,	,	,
cord-027654-k0uby99n	183	26	117	117	CD
cord-027654-k0uby99n	183	27	with	with	IN
cord-027654-k0uby99n	183	28	an	an	DT
cord-027654-k0uby99n	183	29	increasing	increase	VBG
cord-027654-k0uby99n	183	30	number	number	NN
cord-027654-k0uby99n	183	31	of	of	IN
cord-027654-k0uby99n	183	32	such	such	JJ
cord-027654-k0uby99n	183	33	lines	line	NNS
cord-027654-k0uby99n	183	34	becoming	become	VBG
cord-027654-k0uby99n	183	35	better	well	RBR
cord-027654-k0uby99n	183	36	characterized	characterize	VBN
cord-027654-k0uby99n	183	37	and	and	CC
cord-027654-k0uby99n	183	38	available	available	JJ
cord-027654-k0uby99n	183	39	.	.	.
cord-027654-k0uby99n	184	1	Because	because	IN
cord-027654-k0uby99n	184	2	many	many	JJ
cord-027654-k0uby99n	184	3	infectious	infectious	JJ
cord-027654-k0uby99n	184	4	agents	agent	NNS
cord-027654-k0uby99n	184	5	replicate	replicate	VBP
cord-027654-k0uby99n	184	6	at	at	IN
cord-027654-k0uby99n	184	7	mucosal	mucosal	JJ
cord-027654-k0uby99n	184	8	membranes	membrane	NNS
cord-027654-k0uby99n	184	9	and	and	CC
cord-027654-k0uby99n	184	10	transit	transit	NN
cord-027654-k0uby99n	184	11	through	through	IN
cord-027654-k0uby99n	184	12	the	the	DT
cord-027654-k0uby99n	184	13	gastrointestinal	gastrointestinal	JJ
cord-027654-k0uby99n	184	14	tract	tract	NN
cord-027654-k0uby99n	184	15	for	for	IN
cord-027654-k0uby99n	184	16	primary	primary	JJ
cord-027654-k0uby99n	184	17	infection	infection	NN
cord-027654-k0uby99n	184	18	,	,	,
cord-027654-k0uby99n	184	19	the	the	DT
cord-027654-k0uby99n	184	20	ability	ability	NN
cord-027654-k0uby99n	184	21	to	to	TO
cord-027654-k0uby99n	184	22	elicit	elicit	VB
cord-027654-k0uby99n	184	23	effective	effective	JJ
cord-027654-k0uby99n	184	24	immune	immune	JJ
cord-027654-k0uby99n	184	25	responses	response	NNS
cord-027654-k0uby99n	184	26	at	at	IN
cord-027654-k0uby99n	184	27	these	these	DT
cord-027654-k0uby99n	184	28	sites	site	NNS
cord-027654-k0uby99n	184	29	is	be	VBZ
cord-027654-k0uby99n	184	30	desirable	desirable	JJ
cord-027654-k0uby99n	184	31	.	.	.
cord-027654-k0uby99n	185	1	A	a	DT
cord-027654-k0uby99n	185	2	variety	variety	NN
cord-027654-k0uby99n	185	3	of	of	IN
cord-027654-k0uby99n	185	4	bacteria	bacteria	NNS
cord-027654-k0uby99n	185	5	are	be	VBP
cord-027654-k0uby99n	185	6	able	able	JJ
cord-027654-k0uby99n	185	7	to	to	TO
cord-027654-k0uby99n	185	8	replicate	replicate	VB
cord-027654-k0uby99n	185	9	at	at	IN
cord-027654-k0uby99n	185	10	mucosal	mucosal	JJ
cord-027654-k0uby99n	185	11	sites	site	NNS
cord-027654-k0uby99n	185	12	of	of	IN
cord-027654-k0uby99n	185	13	natural	natural	JJ
cord-027654-k0uby99n	185	14	infection	infection	NN
cord-027654-k0uby99n	185	15	,	,	,
cord-027654-k0uby99n	185	16	and	and	CC
cord-027654-k0uby99n	185	17	it	-PRON-	PRP
cord-027654-k0uby99n	185	18	has	have	VBZ
cord-027654-k0uby99n	185	19	been	be	VBN
cord-027654-k0uby99n	185	20	proposed	propose	VBN
cord-027654-k0uby99n	185	21	that	that	DT
cord-027654-k0uby99n	185	22	attenuation	attenuation	NN
cord-027654-k0uby99n	185	23	of	of	IN
cord-027654-k0uby99n	185	24	these	these	DT
cord-027654-k0uby99n	185	25	microorganisms	microorganism	NNS
cord-027654-k0uby99n	185	26	and	and	CC
cord-027654-k0uby99n	185	27	modifi	modifi	JJ
cord-027654-k0uby99n	185	28	cation	cation	NN
cord-027654-k0uby99n	185	29	to	to	TO
cord-027654-k0uby99n	185	30	facilitate	facilitate	VB
cord-027654-k0uby99n	185	31	the	the	DT
cord-027654-k0uby99n	185	32	delivery	delivery	NN
cord-027654-k0uby99n	185	33	of	of	IN
cord-027654-k0uby99n	185	34	antigen	antigen	NN
cord-027654-k0uby99n	185	35	might	may	MD
cord-027654-k0uby99n	185	36	allow	allow	VB
cord-027654-k0uby99n	185	37	the	the	DT
cord-027654-k0uby99n	185	38	development	development	NN
cord-027654-k0uby99n	185	39	of	of	IN
cord-027654-k0uby99n	185	40	improved	improved	JJ
cord-027654-k0uby99n	185	41	vaccines	vaccine	NNS
cord-027654-k0uby99n	185	42	to	to	TO
cord-027654-k0uby99n	185	43	protect	protect	VB
cord-027654-k0uby99n	185	44	against	against	IN
cord-027654-k0uby99n	185	45	pathogens	pathogen	NNS
cord-027654-k0uby99n	185	46	that	that	WDT
cord-027654-k0uby99n	185	47	enter	enter	VBP
cord-027654-k0uby99n	185	48	through	through	IN
cord-027654-k0uby99n	185	49	the	the	DT
cord-027654-k0uby99n	185	50	mucosa	mucosa	NN
cord-027654-k0uby99n	185	51	.	.	.
cord-027654-k0uby99n	186	1	Development	development	NN
cord-027654-k0uby99n	186	2	of	of	IN
cord-027654-k0uby99n	186	3	live	live	JJ
cord-027654-k0uby99n	186	4	bacterial	bacterial	JJ
cord-027654-k0uby99n	186	5	vectors	vector	NNS
cord-027654-k0uby99n	186	6	has	have	VBZ
cord-027654-k0uby99n	186	7	therefore	therefore	RB
cord-027654-k0uby99n	186	8	focused	focus	VBN
cord-027654-k0uby99n	186	9	on	on	IN
cord-027654-k0uby99n	186	10	both	both	DT
cord-027654-k0uby99n	186	11	their	-PRON-	PRP$
cord-027654-k0uby99n	186	12	ability	ability	NN
cord-027654-k0uby99n	186	13	to	to	TO
cord-027654-k0uby99n	186	14	induce	induce	VB
cord-027654-k0uby99n	186	15	mucosal	mucosal	JJ
cord-027654-k0uby99n	186	16	IgA	IgA	NNP
cord-027654-k0uby99n	186	17	responses	response	NNS
cord-027654-k0uby99n	186	18	as	as	RB
cord-027654-k0uby99n	186	19	well	well	RB
cord-027654-k0uby99n	186	20	as	as	IN
cord-027654-k0uby99n	186	21	cytolytic	cytolytic	JJ
cord-027654-k0uby99n	186	22	T	T	NNP
cord-027654-k0uby99n	186	23	cell	cell	NN
cord-027654-k0uby99n	186	24	responses	response	NNS
cord-027654-k0uby99n	186	25	at	at	IN
cord-027654-k0uby99n	186	26	mucosal	mucosal	JJ
cord-027654-k0uby99n	186	27	sites	site	NNS
cord-027654-k0uby99n	186	28	.	.	.
cord-027654-k0uby99n	187	1	The	the	DT
cord-027654-k0uby99n	187	2	delivery	delivery	NN
cord-027654-k0uby99n	187	3	of	of	IN
cord-027654-k0uby99n	187	4	antigens	antigen	NNS
cord-027654-k0uby99n	187	5	into	into	IN
cord-027654-k0uby99n	187	6	mammalian	mammalian	JJ
cord-027654-k0uby99n	187	7	cells	cell	NNS
cord-027654-k0uby99n	187	8	to	to	TO
cord-027654-k0uby99n	187	9	stimulate	stimulate	VB
cord-027654-k0uby99n	187	10	antibody	antibody	NN
cord-027654-k0uby99n	187	11	responses	response	NNS
cord-027654-k0uby99n	187	12	does	do	VBZ
cord-027654-k0uby99n	187	13	not	not	RB
cord-027654-k0uby99n	187	14	require	require	VB
cord-027654-k0uby99n	187	15	the	the	DT
cord-027654-k0uby99n	187	16	types	type	NNS
cord-027654-k0uby99n	187	17	of	of	IN
cord-027654-k0uby99n	187	18	novel	novel	JJ
cord-027654-k0uby99n	187	19	gene	gene	NN
cord-027654-k0uby99n	187	20	-	-	HYPH
cord-027654-k0uby99n	187	21	based	base	VBN
cord-027654-k0uby99n	187	22	vaccines	vaccine	NNS
cord-027654-k0uby99n	187	23	summarized	summarize	VBN
cord-027654-k0uby99n	187	24	in	in	IN
cord-027654-k0uby99n	187	25	this	this	DT
cord-027654-k0uby99n	187	26	chapter	chapter	NN
cord-027654-k0uby99n	187	27	.	.	.
cord-027654-k0uby99n	188	1	On	on	IN
cord-027654-k0uby99n	188	2	the	the	DT
cord-027654-k0uby99n	188	3	other	other	JJ
cord-027654-k0uby99n	188	4	hand	hand	NN
cord-027654-k0uby99n	188	5	,	,	,
cord-027654-k0uby99n	188	6	the	the	DT
cord-027654-k0uby99n	188	7	synthesis	synthesis	NN
cord-027654-k0uby99n	188	8	of	of	IN
cord-027654-k0uby99n	188	9	proteins	protein	NNS
cord-027654-k0uby99n	188	10	within	within	IN
cord-027654-k0uby99n	188	11	mammalian	mammalian	JJ
cord-027654-k0uby99n	188	12	cells	cell	NNS
cord-027654-k0uby99n	188	13	delivered	deliver	VBN
cord-027654-k0uby99n	188	14	by	by	IN
cord-027654-k0uby99n	188	15	bacterial	bacterial	JJ
cord-027654-k0uby99n	188	16	vectors	vector	NNS
cord-027654-k0uby99n	188	17	has	have	VBZ
cord-027654-k0uby99n	188	18	the	the	DT
cord-027654-k0uby99n	188	19	potential	potential	NN
cord-027654-k0uby99n	188	20	to	to	TO
cord-027654-k0uby99n	188	21	induce	induce	VB
cord-027654-k0uby99n	188	22	the	the	DT
cord-027654-k0uby99n	188	23	cellular	cellular	JJ
cord-027654-k0uby99n	188	24	immunity	immunity	NN
cord-027654-k0uby99n	188	25	that	that	WDT
cord-027654-k0uby99n	188	26	is	be	VBZ
cord-027654-k0uby99n	188	27	the	the	DT
cord-027654-k0uby99n	188	28	goal	goal	NN
cord-027654-k0uby99n	188	29	of	of	IN
cord-027654-k0uby99n	188	30	many	many	JJ
cord-027654-k0uby99n	188	31	gene	gene	NN
cord-027654-k0uby99n	188	32	-	-	HYPH
cord-027654-k0uby99n	188	33	based	base	VBN
cord-027654-k0uby99n	188	34	viral	viral	JJ
cord-027654-k0uby99n	188	35	and	and	CC
cord-027654-k0uby99n	188	36	nonviral	nonviral	JJ
cord-027654-k0uby99n	188	37	vaccines	vaccine	NNS
cord-027654-k0uby99n	188	38	.	.	.
cord-027654-k0uby99n	189	1	These	these	DT
cord-027654-k0uby99n	189	2	approaches	approach	NNS
cord-027654-k0uby99n	189	3	have	have	VBP
cord-027654-k0uby99n	189	4	been	be	VBN
cord-027654-k0uby99n	189	5	reviewed	review	VBN
cord-027654-k0uby99n	189	6	in	in	IN
cord-027654-k0uby99n	189	7	detail	detail	NN
cord-027654-k0uby99n	189	8	elsewhere	elsewhere	RB
cord-027654-k0uby99n	189	9	[	[	-LRB-
cord-027654-k0uby99n	189	10	118	118	CD
cord-027654-k0uby99n	189	11	]	]	-RRB-
cord-027654-k0uby99n	189	12	[	[	-LRB-
cord-027654-k0uby99n	189	13	119	119	CD
cord-027654-k0uby99n	189	14	]	]	-RRB-
cord-027654-k0uby99n	189	15	[	[	-LRB-
cord-027654-k0uby99n	189	16	120	120	CD
cord-027654-k0uby99n	189	17	]	]	-RRB-
cord-027654-k0uby99n	189	18	and	and	CC
cord-027654-k0uby99n	189	19	are	be	VBP
cord-027654-k0uby99n	189	20	summarized	summarize	VBN
cord-027654-k0uby99n	189	21	briefl	briefl	NNP
cord-027654-k0uby99n	189	22	y	y	NNP
cord-027654-k0uby99n	189	23	here	here	RB
cord-027654-k0uby99n	189	24	.	.	.
cord-027654-k0uby99n	190	1	Among	among	IN
cord-027654-k0uby99n	190	2	the	the	DT
cord-027654-k0uby99n	190	3	live	live	JJ
cord-027654-k0uby99n	190	4	bacterial	bacterial	JJ
cord-027654-k0uby99n	190	5	vectors	vector	NNS
cord-027654-k0uby99n	190	6	used	use	VBN
cord-027654-k0uby99n	190	7	for	for	IN
cord-027654-k0uby99n	190	8	antigen	antigen	NN
cord-027654-k0uby99n	190	9	delivery	delivery	NN
cord-027654-k0uby99n	190	10	,	,	,
cord-027654-k0uby99n	190	11	there	there	EX
cord-027654-k0uby99n	190	12	are	be	VBP
cord-027654-k0uby99n	190	13	attenuated	attenuated	JJ
cord-027654-k0uby99n	190	14	mucosal	mucosal	JJ
cord-027654-k0uby99n	190	15	pathogens	pathogen	NNS
cord-027654-k0uby99n	190	16	,	,	,
cord-027654-k0uby99n	190	17	such	such	JJ
cord-027654-k0uby99n	190	18	as	as	IN
cord-027654-k0uby99n	190	19	Listeria	Listeria	NNP
cord-027654-k0uby99n	190	20	monocytogenes	monocytogenes	NNP
cord-027654-k0uby99n	190	21	,	,	,
cord-027654-k0uby99n	190	22	Salmonella	Salmonella	NNP
cord-027654-k0uby99n	190	23	,	,	,
cord-027654-k0uby99n	190	24	Vibrio	Vibrio	NNP
cord-027654-k0uby99n	190	25	cholera	cholera	NN
cord-027654-k0uby99n	190	26	,	,	,
cord-027654-k0uby99n	190	27	Shigella	Shigella	NNP
cord-027654-k0uby99n	190	28	,	,	,
cord-027654-k0uby99n	190	29	Mycobacteria	Mycobacteria	NNP
cord-027654-k0uby99n	190	30	bovis	bovi	NNS
cord-027654-k0uby99n	190	31	,	,	,
cord-027654-k0uby99n	190	32	Yersinia	Yersinia	NNP
cord-027654-k0uby99n	190	33	enterocolitica	enterocolitica	NNP
cord-027654-k0uby99n	190	34	and	and	CC
cord-027654-k0uby99n	190	35	Bacillus	Bacillus	NNP
cord-027654-k0uby99n	190	36	anthracis	anthracis	NN
cord-027654-k0uby99n	190	37	.	.	.
cord-027654-k0uby99n	191	1	In	in	IN
cord-027654-k0uby99n	191	2	addition	addition	NN
cord-027654-k0uby99n	191	3	,	,	,
cord-027654-k0uby99n	191	4	there	there	EX
cord-027654-k0uby99n	191	5	are	be	VBP
cord-027654-k0uby99n	191	6	commensal	commensal	JJ
cord-027654-k0uby99n	191	7	strains	strain	NNS
cord-027654-k0uby99n	191	8	such	such	JJ
cord-027654-k0uby99n	191	9	as	as	IN
cord-027654-k0uby99n	191	10	S.	S.	NNP
cord-027654-k0uby99n	191	11	gordonii	gordonii	NNP
cord-027654-k0uby99n	191	12	,	,	,
cord-027654-k0uby99n	191	13	lactobacilli	lactobacilli	NN
cord-027654-k0uby99n	191	14	and	and	CC
cord-027654-k0uby99n	191	15	staphylococci	staphylococcus	NNS
cord-027654-k0uby99n	191	16	that	that	WDT
cord-027654-k0uby99n	191	17	have	have	VBP
cord-027654-k0uby99n	191	18	been	be	VBN
cord-027654-k0uby99n	191	19	used	use	VBN
cord-027654-k0uby99n	191	20	for	for	IN
cord-027654-k0uby99n	191	21	the	the	DT
cord-027654-k0uby99n	191	22	induction	induction	NN
cord-027654-k0uby99n	191	23	of	of	IN
cord-027654-k0uby99n	191	24	humoral	humoral	JJ
cord-027654-k0uby99n	191	25	62	62	CD
cord-027654-k0uby99n	191	26	Chapter	chapter	NN
cord-027654-k0uby99n	191	27	 	 	_SP
cord-027654-k0uby99n	191	28	and	and	CC
cord-027654-k0uby99n	191	29	cellular	cellular	JJ
cord-027654-k0uby99n	191	30	responses	response	NNS
cord-027654-k0uby99n	191	31	.	.	.
cord-027654-k0uby99n	192	1	For	for	IN
cord-027654-k0uby99n	192	2	gene	gene	NN
cord-027654-k0uby99n	192	3	-	-	HYPH
cord-027654-k0uby99n	192	4	based	base	VBN
cord-027654-k0uby99n	192	5	vaccination	vaccination	NN
cord-027654-k0uby99n	192	6	,	,	,
cord-027654-k0uby99n	192	7	Listeria	Listeria	NNP
cord-027654-k0uby99n	192	8	monocytogenes	monocytogene	NNS
cord-027654-k0uby99n	192	9	has	have	VBZ
cord-027654-k0uby99n	192	10	been	be	VBN
cord-027654-k0uby99n	192	11	a	a	DT
cord-027654-k0uby99n	192	12	particular	particular	JJ
cord-027654-k0uby99n	192	13	focus	focus	NN
cord-027654-k0uby99n	192	14	of	of	IN
cord-027654-k0uby99n	192	15	research	research	NN
cord-027654-k0uby99n	192	16	.	.	.
cord-027654-k0uby99n	193	1	This	this	DT
cord-027654-k0uby99n	193	2	gram	gram	NN
cord-027654-k0uby99n	193	3	-	-	HYPH
cord-027654-k0uby99n	193	4	positive	positive	JJ
cord-027654-k0uby99n	193	5	intracellular	intracellular	JJ
cord-027654-k0uby99n	193	6	pathogen	pathogen	NN
cord-027654-k0uby99n	193	7	has	have	VBZ
cord-027654-k0uby99n	193	8	been	be	VBN
cord-027654-k0uby99n	193	9	studied	study	VBN
cord-027654-k0uby99n	193	10	as	as	IN
cord-027654-k0uby99n	193	11	a	a	DT
cord-027654-k0uby99n	193	12	model	model	NN
cord-027654-k0uby99n	193	13	to	to	TO
cord-027654-k0uby99n	193	14	understand	understand	VB
cord-027654-k0uby99n	193	15	class	class	NN
cord-027654-k0uby99n	193	16	I	-PRON-	PRP
cord-027654-k0uby99n	193	17	MHC	MHC	NNP
cord-027654-k0uby99n	193	18	-	-	HYPH
cord-027654-k0uby99n	193	19	restricted	restrict	VBN
cord-027654-k0uby99n	193	20	immune	immune	JJ
cord-027654-k0uby99n	193	21	responses	response	NNS
cord-027654-k0uby99n	193	22	.	.	.
cord-027654-k0uby99n	194	1	These	these	DT
cord-027654-k0uby99n	194	2	responses	response	NNS
cord-027654-k0uby99n	194	3	are	be	VBP
cord-027654-k0uby99n	194	4	normally	normally	RB
cord-027654-k0uby99n	194	5	seen	see	VBN
cord-027654-k0uby99n	194	6	against	against	IN
cord-027654-k0uby99n	194	7	the	the	DT
cord-027654-k0uby99n	194	8	bacterial	bacterial	JJ
cord-027654-k0uby99n	194	9	proteins	protein	NNS
cord-027654-k0uby99n	194	10	or	or	CC
cord-027654-k0uby99n	194	11	co	co	NNS
cord-027654-k0uby99n	194	12	-	-	JJ
cord-027654-k0uby99n	194	13	expressed	express	VBN
cord-027654-k0uby99n	194	14	antigens	antigen	NNS
cord-027654-k0uby99n	194	15	.	.	.
cord-027654-k0uby99n	195	1	This	this	DT
cord-027654-k0uby99n	195	2	microorganism	microorganism	NN
cord-027654-k0uby99n	195	3	utilizes	utilize	VBZ
cord-027654-k0uby99n	195	4	a	a	DT
cord-027654-k0uby99n	195	5	specialized	specialized	JJ
cord-027654-k0uby99n	195	6	system	system	NN
cord-027654-k0uby99n	195	7	to	to	TO
cord-027654-k0uby99n	195	8	introduce	introduce	VB
cord-027654-k0uby99n	195	9	proteins	protein	NNS
cord-027654-k0uby99n	195	10	into	into	IN
cord-027654-k0uby99n	195	11	cells	cell	NNS
cord-027654-k0uby99n	195	12	and	and	CC
cord-027654-k0uby99n	195	13	facilitate	facilitate	VBP
cord-027654-k0uby99n	195	14	processing	processing	NN
cord-027654-k0uby99n	195	15	and	and	CC
cord-027654-k0uby99n	195	16	presentation	presentation	NN
cord-027654-k0uby99n	195	17	through	through	IN
cord-027654-k0uby99n	195	18	MHC	MHC	NNP
cord-027654-k0uby99n	195	19	Class	Class	NNP
cord-027654-k0uby99n	195	20	I	I	NNP
cord-027654-k0uby99n	195	21	,	,	,
cord-027654-k0uby99n	195	22	and	and	CC
cord-027654-k0uby99n	195	23	different	different	JJ
cord-027654-k0uby99n	195	24	mutations	mutation	NNS
cord-027654-k0uby99n	195	25	have	have	VBP
cord-027654-k0uby99n	195	26	been	be	VBN
cord-027654-k0uby99n	195	27	used	use	VBN
cord-027654-k0uby99n	195	28	to	to	TO
cord-027654-k0uby99n	195	29	develop	develop	VB
cord-027654-k0uby99n	195	30	attenuated	attenuated	JJ
cord-027654-k0uby99n	195	31	strains	strain	NNS
cord-027654-k0uby99n	195	32	that	that	WDT
cord-027654-k0uby99n	195	33	retain	retain	VBP
cord-027654-k0uby99n	195	34	the	the	DT
cord-027654-k0uby99n	195	35	ability	ability	NN
cord-027654-k0uby99n	195	36	to	to	TO
cord-027654-k0uby99n	195	37	deliver	deliver	VB
cord-027654-k0uby99n	195	38	antigens	antigen	NNS
cord-027654-k0uby99n	195	39	.	.	.
cord-027654-k0uby99n	196	1	Similarly	similarly	RB
cord-027654-k0uby99n	196	2	,	,	,
cord-027654-k0uby99n	196	3	salmonella	salmonella	NN
cord-027654-k0uby99n	196	4	bacterial	bacterial	JJ
cord-027654-k0uby99n	196	5	strains	strain	NNS
cord-027654-k0uby99n	196	6	are	be	VBP
cord-027654-k0uby99n	196	7	intracellular	intracellular	JJ
cord-027654-k0uby99n	196	8	pathogens	pathogen	NNS
cord-027654-k0uby99n	196	9	that	that	WDT
cord-027654-k0uby99n	196	10	become	become	VBP
cord-027654-k0uby99n	196	11	restricted	restricted	JJ
cord-027654-k0uby99n	196	12	to	to	IN
cord-027654-k0uby99n	196	13	the	the	DT
cord-027654-k0uby99n	196	14	endosomal	endosomal	NNP
cord-027654-k0uby99n	196	15	compartment	compartment	NN
cord-027654-k0uby99n	196	16	of	of	IN
cord-027654-k0uby99n	196	17	eukaryotic	eukaryotic	JJ
cord-027654-k0uby99n	196	18	cells	cell	NNS
cord-027654-k0uby99n	196	19	where	where	WRB
cord-027654-k0uby99n	196	20	they	-PRON-	PRP
cord-027654-k0uby99n	196	21	are	be	VBP
cord-027654-k0uby99n	196	22	resistant	resistant	JJ
cord-027654-k0uby99n	196	23	to	to	IN
cord-027654-k0uby99n	196	24	lysis	lysis	NN
cord-027654-k0uby99n	196	25	.	.	.
cord-027654-k0uby99n	197	1	121	121	CD
cord-027654-k0uby99n	197	2	A	a	DT
cord-027654-k0uby99n	197	3	variety	variety	NN
cord-027654-k0uby99n	197	4	of	of	IN
cord-027654-k0uby99n	197	5	mutations	mutation	NNS
cord-027654-k0uby99n	197	6	have	have	VBP
cord-027654-k0uby99n	197	7	been	be	VBN
cord-027654-k0uby99n	197	8	introduced	introduce	VBN
cord-027654-k0uby99n	197	9	into	into	IN
cord-027654-k0uby99n	197	10	salmonella	salmonella	NN
cord-027654-k0uby99n	197	11	to	to	TO
cord-027654-k0uby99n	197	12	generate	generate	VB
cord-027654-k0uby99n	197	13	several	several	JJ
cord-027654-k0uby99n	197	14	different	different	JJ
cord-027654-k0uby99n	197	15	live	live	JJ
cord-027654-k0uby99n	197	16	vaccine	vaccine	NN
cord-027654-k0uby99n	197	17	carriers	carrier	NNS
cord-027654-k0uby99n	197	18	,	,	,
cord-027654-k0uby99n	197	19	and	and	CC
cord-027654-k0uby99n	197	20	these	these	DT
cord-027654-k0uby99n	197	21	vaccine	vaccine	NN
cord-027654-k0uby99n	197	22	prototypes	prototype	NNS
cord-027654-k0uby99n	197	23	have	have	VBP
cord-027654-k0uby99n	197	24	undergone	undergo	VBN
cord-027654-k0uby99n	197	25	further	further	JJ
cord-027654-k0uby99n	197	26	development	development	NN
cord-027654-k0uby99n	197	27	for	for	IN
cord-027654-k0uby99n	197	28	vaccine	vaccine	NN
cord-027654-k0uby99n	197	29	delivery	delivery	NN
cord-027654-k0uby99n	197	30	.	.	.
cord-027654-k0uby99n	198	1	Among	among	IN
cord-027654-k0uby99n	198	2	the	the	DT
cord-027654-k0uby99n	198	3	other	other	JJ
cord-027654-k0uby99n	198	4	bacterial	bacterial	JJ
cord-027654-k0uby99n	198	5	carriers	carrier	NNS
cord-027654-k0uby99n	198	6	,	,	,
cord-027654-k0uby99n	198	7	Mycobacteria	Mycobacteria	NNP
cord-027654-k0uby99n	198	8	bovis	bovis	NNP
cord-027654-k0uby99n	198	9	Calmette	Calmette	NNP
cord-027654-k0uby99n	198	10	-	-	HYPH
cord-027654-k0uby99n	198	11	Guerin	Guerin	NNP
cord-027654-k0uby99n	198	12	(	(	-LRB-
cord-027654-k0uby99n	198	13	BCG	BCG	NNP
cord-027654-k0uby99n	198	14	)	)	-RRB-
cord-027654-k0uby99n	198	15	has	have	VBZ
cord-027654-k0uby99n	198	16	been	be	VBN
cord-027654-k0uby99n	198	17	a	a	DT
cord-027654-k0uby99n	198	18	widely	widely	RB
cord-027654-k0uby99n	198	19	used	use	VBN
cord-027654-k0uby99n	198	20	bacterial	bacterial	JJ
cord-027654-k0uby99n	198	21	vaccine	vaccine	NN
cord-027654-k0uby99n	198	22	;	;	:
cord-027654-k0uby99n	198	23	for	for	IN
cord-027654-k0uby99n	198	24	example	example	NN
cord-027654-k0uby99n	198	25	,	,	,
cord-027654-k0uby99n	198	26	recently	recently	RB
cord-027654-k0uby99n	198	27	this	this	DT
cord-027654-k0uby99n	198	28	organism	organism	NN
cord-027654-k0uby99n	198	29	has	have	VBZ
cord-027654-k0uby99n	198	30	been	be	VBN
cord-027654-k0uby99n	198	31	used	use	VBN
cord-027654-k0uby99n	198	32	to	to	TO
cord-027654-k0uby99n	198	33	express	express	VB
cord-027654-k0uby99n	198	34	HIV	HIV	NNP
cord-027654-k0uby99n	198	35	antigens	antigen	NNS
cord-027654-k0uby99n	198	36	.	.	.
cord-027654-k0uby99n	199	1	122	122	CD
cord-027654-k0uby99n	199	2	,	,	,
cord-027654-k0uby99n	199	3	123	123	CD
cord-027654-k0uby99n	200	1	In	in	IN
cord-027654-k0uby99n	200	2	some	some	DT
cord-027654-k0uby99n	200	3	instances	instance	NNS
cord-027654-k0uby99n	200	4	,	,	,
cord-027654-k0uby99n	200	5	expression	expression	NN
cord-027654-k0uby99n	200	6	of	of	IN
cord-027654-k0uby99n	200	7	mammalian	mammalian	JJ
cord-027654-k0uby99n	200	8	genes	gene	NNS
cord-027654-k0uby99n	200	9	has	have	VBZ
cord-027654-k0uby99n	200	10	required	require	VBN
cord-027654-k0uby99n	200	11	modifi	modifi	JJ
cord-027654-k0uby99n	200	12	cation	cation	NN
cord-027654-k0uby99n	200	13	of	of	IN
cord-027654-k0uby99n	200	14	codons	codon	NNS
cord-027654-k0uby99n	200	15	more	more	RBR
cord-027654-k0uby99n	200	16	consistent	consistent	JJ
cord-027654-k0uby99n	200	17	with	with	IN
cord-027654-k0uby99n	200	18	the	the	DT
cord-027654-k0uby99n	200	19	host	host	NN
cord-027654-k0uby99n	200	20	cell	cell	NN
cord-027654-k0uby99n	200	21	type	type	NN
cord-027654-k0uby99n	200	22	,	,	,
cord-027654-k0uby99n	200	23	which	which	WDT
cord-027654-k0uby99n	200	24	has	have	VBZ
cord-027654-k0uby99n	200	25	improved	improve	VBN
cord-027654-k0uby99n	200	26	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	200	27	.	.	.
cord-027654-k0uby99n	201	1	At	at	IN
cord-027654-k0uby99n	201	2	the	the	DT
cord-027654-k0uby99n	201	3	present	present	JJ
cord-027654-k0uby99n	201	4	time	time	NN
cord-027654-k0uby99n	201	5	,	,	,
cord-027654-k0uby99n	201	6	however	however	RB
cord-027654-k0uby99n	201	7	,	,	,
cord-027654-k0uby99n	201	8	the	the	DT
cord-027654-k0uby99n	201	9	ability	ability	NN
cord-027654-k0uby99n	201	10	of	of	IN
cord-027654-k0uby99n	201	11	such	such	JJ
cord-027654-k0uby99n	201	12	microorganisms	microorganism	NNS
cord-027654-k0uby99n	201	13	to	to	TO
cord-027654-k0uby99n	201	14	induce	induce	VB
cord-027654-k0uby99n	201	15	cellular	cellular	JJ
cord-027654-k0uby99n	201	16	immunity	immunity	NN
cord-027654-k0uby99n	201	17	has	have	VBZ
cord-027654-k0uby99n	201	18	been	be	VBN
cord-027654-k0uby99n	201	19	limited	limit	VBN
cord-027654-k0uby99n	201	20	.	.	.
cord-027654-k0uby99n	202	1	An	an	DT
cord-027654-k0uby99n	202	2	area	area	NN
cord-027654-k0uby99n	202	3	of	of	IN
cord-027654-k0uby99n	202	4	intense	intense	JJ
cord-027654-k0uby99n	202	5	interest	interest	NN
cord-027654-k0uby99n	202	6	has	have	VBZ
cord-027654-k0uby99n	202	7	been	be	VBN
cord-027654-k0uby99n	202	8	the	the	DT
cord-027654-k0uby99n	202	9	use	use	NN
cord-027654-k0uby99n	202	10	of	of	IN
cord-027654-k0uby99n	202	11	live	live	JJ
cord-027654-k0uby99n	202	12	bacterial	bacterial	JJ
cord-027654-k0uby99n	202	13	vectors	vector	NNS
cord-027654-k0uby99n	202	14	for	for	IN
cord-027654-k0uby99n	202	15	the	the	DT
cord-027654-k0uby99n	202	16	delivery	delivery	NN
cord-027654-k0uby99n	202	17	of	of	IN
cord-027654-k0uby99n	202	18	DNA	dna	NN
cord-027654-k0uby99n	202	19	vaccines	vaccine	NNS
cord-027654-k0uby99n	202	20	.	.	.
cord-027654-k0uby99n	203	1	In	in	IN
cord-027654-k0uby99n	203	2	this	this	DT
cord-027654-k0uby99n	203	3	instance	instance	NN
cord-027654-k0uby99n	203	4	,	,	,
cord-027654-k0uby99n	203	5	the	the	DT
cord-027654-k0uby99n	203	6	aim	aim	NN
cord-027654-k0uby99n	203	7	is	be	VBZ
cord-027654-k0uby99n	203	8	for	for	IN
cord-027654-k0uby99n	203	9	the	the	DT
cord-027654-k0uby99n	203	10	bacteria	bacteria	NNS
cord-027654-k0uby99n	203	11	to	to	TO
cord-027654-k0uby99n	203	12	deliver	deliver	VB
cord-027654-k0uby99n	203	13	plasmid	plasmid	NN
cord-027654-k0uby99n	203	14	DNA	dna	NN
cord-027654-k0uby99n	203	15	into	into	IN
cord-027654-k0uby99n	203	16	the	the	DT
cord-027654-k0uby99n	203	17	cytoplasm	cytoplasm	NN
cord-027654-k0uby99n	203	18	of	of	IN
cord-027654-k0uby99n	203	19	infected	infected	JJ
cord-027654-k0uby99n	203	20	cells	cell	NNS
cord-027654-k0uby99n	203	21	;	;	:
cord-027654-k0uby99n	203	22	such	such	JJ
cord-027654-k0uby99n	203	23	organisms	organism	NNS
cord-027654-k0uby99n	203	24	as	as	IN
cord-027654-k0uby99n	203	25	Shigella	Shigella	NNP
cord-027654-k0uby99n	203	26	and	and	CC
cord-027654-k0uby99n	203	27	Listeria	Listeria	NNP
cord-027654-k0uby99n	203	28	have	have	VBP
cord-027654-k0uby99n	203	29	been	be	VBN
cord-027654-k0uby99n	203	30	used	use	VBN
cord-027654-k0uby99n	203	31	for	for	IN
cord-027654-k0uby99n	203	32	this	this	DT
cord-027654-k0uby99n	203	33	purpose	purpose	NN
cord-027654-k0uby99n	203	34	.	.	.
cord-027654-k0uby99n	204	1	124	124	CD
cord-027654-k0uby99n	204	2	,	,	,
cord-027654-k0uby99n	205	1	125	125	CD
cord-027654-k0uby99n	206	1	In	in	IN
cord-027654-k0uby99n	206	2	addition	addition	NN
cord-027654-k0uby99n	206	3	,	,	,
cord-027654-k0uby99n	206	4	attenuated	attenuated	JJ
cord-027654-k0uby99n	206	5	Salmonella	Salmonella	NNP
cord-027654-k0uby99n	206	6	has	have	VBZ
cord-027654-k0uby99n	206	7	been	be	VBN
cord-027654-k0uby99n	206	8	evaluated	evaluate	VBN
cord-027654-k0uby99n	206	9	and	and	CC
cord-027654-k0uby99n	206	10	has	have	VBZ
cord-027654-k0uby99n	206	11	shown	show	VBN
cord-027654-k0uby99n	206	12	some	some	DT
cord-027654-k0uby99n	206	13	promise	promise	NN
cord-027654-k0uby99n	206	14	in	in	IN
cord-027654-k0uby99n	206	15	both	both	CC
cord-027654-k0uby99n	206	16	infectious	infectious	JJ
cord-027654-k0uby99n	206	17	disease	disease	NN
cord-027654-k0uby99n	206	18	and	and	CC
cord-027654-k0uby99n	206	19	tumor	tumor	NN
cord-027654-k0uby99n	206	20	models	model	NNS
cord-027654-k0uby99n	206	21	in	in	IN
cord-027654-k0uby99n	206	22	experimental	experimental	JJ
cord-027654-k0uby99n	206	23	animals	animal	NNS
cord-027654-k0uby99n	206	24	.	.	.
cord-027654-k0uby99n	207	1	[	[	-LRB-
cord-027654-k0uby99n	207	2	126	126	CD
cord-027654-k0uby99n	207	3	]	]	-RRB-
cord-027654-k0uby99n	207	4	[	[	-LRB-
cord-027654-k0uby99n	207	5	127	127	CD
cord-027654-k0uby99n	207	6	]	]	-RRB-
cord-027654-k0uby99n	208	1	[	[	-LRB-
cord-027654-k0uby99n	208	2	128	128	CD
cord-027654-k0uby99n	208	3	]	]	-RRB-
cord-027654-k0uby99n	209	1	While	while	IN
cord-027654-k0uby99n	209	2	the	the	DT
cord-027654-k0uby99n	209	3	use	use	NN
cord-027654-k0uby99n	209	4	of	of	IN
cord-027654-k0uby99n	209	5	such	such	JJ
cord-027654-k0uby99n	209	6	bacterial	bacterial	JJ
cord-027654-k0uby99n	209	7	vectors	vector	NNS
cord-027654-k0uby99n	209	8	has	have	VBZ
cord-027654-k0uby99n	209	9	been	be	VBN
cord-027654-k0uby99n	209	10	attractive	attractive	JJ
cord-027654-k0uby99n	209	11	in	in	IN
cord-027654-k0uby99n	209	12	theory	theory	NN
cord-027654-k0uby99n	209	13	,	,	,
cord-027654-k0uby99n	209	14	it	-PRON-	PRP
cord-027654-k0uby99n	209	15	has	have	VBZ
cord-027654-k0uby99n	209	16	been	be	VBN
cord-027654-k0uby99n	209	17	more	more	RBR
cord-027654-k0uby99n	209	18	diffi	diffi	JJ
cord-027654-k0uby99n	209	19	cult	cult	NN
cord-027654-k0uby99n	209	20	to	to	TO
cord-027654-k0uby99n	209	21	reduce	reduce	VB
cord-027654-k0uby99n	209	22	this	this	DT
cord-027654-k0uby99n	209	23	method	method	NN
cord-027654-k0uby99n	209	24	to	to	TO
cord-027654-k0uby99n	209	25	practice	practice	VB
cord-027654-k0uby99n	209	26	.	.	.
cord-027654-k0uby99n	210	1	Among	among	IN
cord-027654-k0uby99n	210	2	the	the	DT
cord-027654-k0uby99n	210	3	concerns	concern	NNS
cord-027654-k0uby99n	210	4	is	be	VBZ
cord-027654-k0uby99n	210	5	the	the	DT
cord-027654-k0uby99n	210	6	possibility	possibility	NN
cord-027654-k0uby99n	210	7	of	of	IN
cord-027654-k0uby99n	210	8	reversion	reversion	NN
cord-027654-k0uby99n	210	9	or	or	CC
cord-027654-k0uby99n	210	10	reactogenicity	reactogenicity	NN
cord-027654-k0uby99n	210	11	of	of	IN
cord-027654-k0uby99n	210	12	these	these	DT
cord-027654-k0uby99n	210	13	potentially	potentially	RB
cord-027654-k0uby99n	210	14	pathogenic	pathogenic	JJ
cord-027654-k0uby99n	210	15	bacteria	bacteria	NNS
cord-027654-k0uby99n	210	16	to	to	IN
cord-027654-k0uby99n	210	17	wild	wild	JJ
cord-027654-k0uby99n	210	18	type	type	NN
cord-027654-k0uby99n	210	19	forms	form	NNS
cord-027654-k0uby99n	210	20	,	,	,
cord-027654-k0uby99n	210	21	the	the	DT
cord-027654-k0uby99n	210	22	stability	stability	NN
cord-027654-k0uby99n	210	23	of	of	IN
cord-027654-k0uby99n	210	24	the	the	DT
cord-027654-k0uby99n	210	25	recombinant	recombinant	JJ
cord-027654-k0uby99n	210	26	bacteria	bacteria	NNS
cord-027654-k0uby99n	210	27	,	,	,
cord-027654-k0uby99n	210	28	as	as	RB
cord-027654-k0uby99n	210	29	well	well	RB
cord-027654-k0uby99n	210	30	as	as	IN
cord-027654-k0uby99n	210	31	the	the	DT
cord-027654-k0uby99n	210	32	possibility	possibility	NN
cord-027654-k0uby99n	210	33	that	that	IN
cord-027654-k0uby99n	210	34	pre	pre	JJ
cord-027654-k0uby99n	210	35	-	-	JJ
cord-027654-k0uby99n	210	36	existing	existing	JJ
cord-027654-k0uby99n	210	37	immunity	immunity	NN
cord-027654-k0uby99n	210	38	from	from	IN
cord-027654-k0uby99n	210	39	exposure	exposure	NN
cord-027654-k0uby99n	210	40	to	to	IN
cord-027654-k0uby99n	210	41	natural	natural	JJ
cord-027654-k0uby99n	210	42	pathogens	pathogen	NNS
cord-027654-k0uby99n	210	43	may	may	MD
cord-027654-k0uby99n	210	44	limit	limit	VB
cord-027654-k0uby99n	210	45	their	-PRON-	PRP$
cord-027654-k0uby99n	210	46	infectivity	infectivity	NN
cord-027654-k0uby99n	210	47	.	.	.
cord-027654-k0uby99n	211	1	A	a	DT
cord-027654-k0uby99n	211	2	variety	variety	NN
cord-027654-k0uby99n	211	3	of	of	IN
cord-027654-k0uby99n	211	4	host	host	JJ
cord-027654-k0uby99n	211	5	genetic	genetic	JJ
cord-027654-k0uby99n	211	6	factors	factor	NNS
cord-027654-k0uby99n	211	7	can	can	MD
cord-027654-k0uby99n	211	8	modulate	modulate	VB
cord-027654-k0uby99n	211	9	the	the	DT
cord-027654-k0uby99n	211	10	immune	immune	JJ
cord-027654-k0uby99n	211	11	response	response	NN
cord-027654-k0uby99n	211	12	induced	induce	VBN
cord-027654-k0uby99n	211	13	by	by	IN
cord-027654-k0uby99n	211	14	the	the	DT
cord-027654-k0uby99n	211	15	bacterial	bacterial	JJ
cord-027654-k0uby99n	211	16	carrier	carrier	NN
cord-027654-k0uby99n	211	17	,	,	,
cord-027654-k0uby99n	211	18	and	and	CC
cord-027654-k0uby99n	211	19	variability	variability	NN
cord-027654-k0uby99n	211	20	in	in	IN
cord-027654-k0uby99n	211	21	the	the	DT
cord-027654-k0uby99n	211	22	innate	innate	JJ
cord-027654-k0uby99n	211	23	immune	immune	JJ
cord-027654-k0uby99n	211	24	responses	response	NNS
cord-027654-k0uby99n	211	25	to	to	IN
cord-027654-k0uby99n	211	26	such	such	JJ
cord-027654-k0uby99n	211	27	pathogens	pathogen	NNS
cord-027654-k0uby99n	211	28	may	may	MD
cord-027654-k0uby99n	211	29	limit	limit	VB
cord-027654-k0uby99n	211	30	their	-PRON-	PRP$
cord-027654-k0uby99n	211	31	consistency	consistency	NN
cord-027654-k0uby99n	211	32	in	in	IN
cord-027654-k0uby99n	211	33	vivo	vivo	NNP
cord-027654-k0uby99n	211	34	.	.	.
cord-027654-k0uby99n	212	1	Finally	finally	RB
cord-027654-k0uby99n	212	2	,	,	,
cord-027654-k0uby99n	212	3	perhaps	perhaps	RB
cord-027654-k0uby99n	212	4	the	the	DT
cord-027654-k0uby99n	212	5	most	most	RBS
cord-027654-k0uby99n	212	6	challenging	challenging	JJ
cord-027654-k0uby99n	212	7	problem	problem	NN
cord-027654-k0uby99n	212	8	has	have	VBZ
cord-027654-k0uby99n	212	9	been	be	VBN
cord-027654-k0uby99n	212	10	the	the	DT
cord-027654-k0uby99n	212	11	ability	ability	NN
cord-027654-k0uby99n	212	12	to	to	TO
cord-027654-k0uby99n	212	13	effect	effect	VB
cord-027654-k0uby99n	212	14	a	a	DT
cord-027654-k0uby99n	212	15	gene	gene	NN
cord-027654-k0uby99n	212	16	transfer	transfer	NN
cord-027654-k0uby99n	212	17	from	from	IN
cord-027654-k0uby99n	212	18	bacteria	bacteria	NNS
cord-027654-k0uby99n	212	19	into	into	IN
cord-027654-k0uby99n	212	20	mammalian	mammalian	JJ
cord-027654-k0uby99n	212	21	cells	cell	NNS
cord-027654-k0uby99n	212	22	.	.	.
cord-027654-k0uby99n	213	1	It	-PRON-	PRP
cord-027654-k0uby99n	213	2	is	be	VBZ
cord-027654-k0uby99n	213	3	likely	likely	JJ
cord-027654-k0uby99n	213	4	that	that	IN
cord-027654-k0uby99n	213	5	very	very	RB
cord-027654-k0uby99n	213	6	specialized	specialized	JJ
cord-027654-k0uby99n	213	7	transport	transport	NN
cord-027654-k0uby99n	213	8	pathways	pathway	NNS
cord-027654-k0uby99n	213	9	are	be	VBP
cord-027654-k0uby99n	213	10	required	require	VBN
cord-027654-k0uby99n	213	11	for	for	IN
cord-027654-k0uby99n	213	12	the	the	DT
cord-027654-k0uby99n	213	13	successful	successful	JJ
cord-027654-k0uby99n	213	14	implementation	implementation	NN
cord-027654-k0uby99n	213	15	of	of	IN
cord-027654-k0uby99n	213	16	this	this	DT
cord-027654-k0uby99n	213	17	technology	technology	NN
cord-027654-k0uby99n	213	18	,	,	,
cord-027654-k0uby99n	213	19	and	and	CC
cord-027654-k0uby99n	213	20	additional	additional	JJ
cord-027654-k0uby99n	213	21	improvements	improvement	NNS
cord-027654-k0uby99n	213	22	in	in	IN
cord-027654-k0uby99n	213	23	the	the	DT
cord-027654-k0uby99n	213	24	future	future	NN
cord-027654-k0uby99n	213	25	will	will	MD
cord-027654-k0uby99n	213	26	be	be	VB
cord-027654-k0uby99n	213	27	necessary	necessary	JJ
cord-027654-k0uby99n	213	28	to	to	TO
cord-027654-k0uby99n	213	29	improve	improve	VB
cord-027654-k0uby99n	213	30	the	the	DT
cord-027654-k0uby99n	213	31	effi	effi	NNP
cord-027654-k0uby99n	213	32	cacy	cacy	NN
cord-027654-k0uby99n	213	33	of	of	IN
cord-027654-k0uby99n	213	34	this	this	DT
cord-027654-k0uby99n	213	35	approach	approach	NN
cord-027654-k0uby99n	213	36	,	,	,
cord-027654-k0uby99n	213	37	which	which	WDT
cord-027654-k0uby99n	213	38	remains	remain	VBZ
cord-027654-k0uby99n	213	39	limited	limited	JJ
cord-027654-k0uby99n	213	40	in	in	IN
cord-027654-k0uby99n	213	41	its	-PRON-	PRP$
cord-027654-k0uby99n	213	42	present	present	JJ
cord-027654-k0uby99n	213	43	form	form	NN
cord-027654-k0uby99n	213	44	.	.	.
cord-027654-k0uby99n	214	1	While	while	IN
cord-027654-k0uby99n	214	2	substantial	substantial	JJ
cord-027654-k0uby99n	214	3	work	work	NN
cord-027654-k0uby99n	214	4	has	have	VBZ
cord-027654-k0uby99n	214	5	progressed	progress	VBN
cord-027654-k0uby99n	214	6	in	in	IN
cord-027654-k0uby99n	214	7	animal	animal	NN
cord-027654-k0uby99n	214	8	models	model	NNS
cord-027654-k0uby99n	214	9	of	of	IN
cord-027654-k0uby99n	214	10	vaccine	vaccine	NN
cord-027654-k0uby99n	214	11	effi	effi	NNP
cord-027654-k0uby99n	214	12	cacy	cacy	NNP
cord-027654-k0uby99n	214	13	,	,	,
cord-027654-k0uby99n	214	14	the	the	DT
cord-027654-k0uby99n	214	15	ultimate	ultimate	JJ
cord-027654-k0uby99n	214	16	value	value	NN
cord-027654-k0uby99n	214	17	of	of	IN
cord-027654-k0uby99n	214	18	gene	gene	NN
cord-027654-k0uby99n	214	19	-	-	HYPH
cord-027654-k0uby99n	214	20	based	base	VBN
cord-027654-k0uby99n	214	21	vaccination	vaccination	NN
cord-027654-k0uby99n	214	22	has	have	VBZ
cord-027654-k0uby99n	214	23	yet	yet	RB
cord-027654-k0uby99n	214	24	to	to	TO
cord-027654-k0uby99n	214	25	be	be	VB
cord-027654-k0uby99n	214	26	shown	show	VBN
cord-027654-k0uby99n	214	27	in	in	IN
cord-027654-k0uby99n	214	28	human	human	JJ
cord-027654-k0uby99n	214	29	studies	study	NNS
cord-027654-k0uby99n	214	30	.	.	.
cord-027654-k0uby99n	215	1	Several	several	JJ
cord-027654-k0uby99n	215	2	trials	trial	NNS
cord-027654-k0uby99n	215	3	using	use	VBG
cord-027654-k0uby99n	215	4	the	the	DT
cord-027654-k0uby99n	215	5	poxvirus	poxvirus	NNP
cord-027654-k0uby99n	215	6	technology	technology	NN
cord-027654-k0uby99n	215	7	have	have	VBP
cord-027654-k0uby99n	215	8	advanced	advance	VBN
cord-027654-k0uby99n	215	9	into	into	IN
cord-027654-k0uby99n	215	10	clinical	clinical	JJ
cord-027654-k0uby99n	215	11	evaluation	evaluation	NN
cord-027654-k0uby99n	215	12	.	.	.
cord-027654-k0uby99n	216	1	These	these	DT
cord-027654-k0uby99n	216	2	include	include	VBP
cord-027654-k0uby99n	216	3	canarypox	canarypox	NN
cord-027654-k0uby99n	216	4	,	,	,
cord-027654-k0uby99n	216	5	which	which	WDT
cord-027654-k0uby99n	216	6	has	have	VBZ
cord-027654-k0uby99n	216	7	progressed	progress	VBN
cord-027654-k0uby99n	216	8	through	through	IN
cord-027654-k0uby99n	216	9	Phase	Phase	NNP
cord-027654-k0uby99n	216	10	II	II	NNP
cord-027654-k0uby99n	216	11	studies	study	NNS
cord-027654-k0uby99n	216	12	in	in	IN
cord-027654-k0uby99n	216	13	the	the	DT
cord-027654-k0uby99n	216	14	United	United	NNP
cord-027654-k0uby99n	216	15	States	States	NNP
cord-027654-k0uby99n	216	16	for	for	IN
cord-027654-k0uby99n	216	17	HIV	HIV	NNP
cord-027654-k0uby99n	216	18	vaccine	vaccine	NN
cord-027654-k0uby99n	216	19	evaluation	evaluation	NN
cord-027654-k0uby99n	216	20	,	,	,
cord-027654-k0uby99n	216	21	and	and	CC
cord-027654-k0uby99n	216	22	has	have	VBZ
cord-027654-k0uby99n	216	23	advanced	advance	VBN
cord-027654-k0uby99n	216	24	into	into	IN
cord-027654-k0uby99n	216	25	a	a	DT
cord-027654-k0uby99n	216	26	proof	proof	NN
cord-027654-k0uby99n	216	27	-	-	HYPH
cord-027654-k0uby99n	216	28	of	of	IN
cord-027654-k0uby99n	216	29	-	-	HYPH
cord-027654-k0uby99n	216	30	concept	concept	NN
cord-027654-k0uby99n	216	31	effi	effi	NNP
cord-027654-k0uby99n	216	32	cacy	cacy	NNP
cord-027654-k0uby99n	216	33	trial	trial	NN
cord-027654-k0uby99n	216	34	currently	currently	RB
cord-027654-k0uby99n	216	35	in	in	IN
cord-027654-k0uby99n	216	36	progress	progress	NN
cord-027654-k0uby99n	216	37	in	in	IN
cord-027654-k0uby99n	216	38	Thailand	Thailand	NNP
cord-027654-k0uby99n	216	39	.	.	.
cord-027654-k0uby99n	217	1	In	in	IN
cord-027654-k0uby99n	217	2	addition	addition	NN
cord-027654-k0uby99n	217	3	,	,	,
cord-027654-k0uby99n	217	4	both	both	CC
cord-027654-k0uby99n	217	5	modifi	modifi	NNP
cord-027654-k0uby99n	217	6	ed	ed	NN
cord-027654-k0uby99n	217	7	vaccinia	vaccinia	NN
cord-027654-k0uby99n	217	8	Ankara	Ankara	NNP
cord-027654-k0uby99n	217	9	and	and	CC
cord-027654-k0uby99n	217	10	NYVAC	NYVAC	NNP
cord-027654-k0uby99n	217	11	have	have	VBP
cord-027654-k0uby99n	217	12	been	be	VBN
cord-027654-k0uby99n	217	13	evaluated	evaluate	VBN
cord-027654-k0uby99n	217	14	in	in	IN
cord-027654-k0uby99n	217	15	phase	phase	NN
cord-027654-k0uby99n	217	16	I	-PRON-	PRP
cord-027654-k0uby99n	217	17	human	human	JJ
cord-027654-k0uby99n	217	18	studies	study	NNS
cord-027654-k0uby99n	217	19	.	.	.
cord-027654-k0uby99n	218	1	Because	because	IN
cord-027654-k0uby99n	218	2	the	the	DT
cord-027654-k0uby99n	218	3	production	production	NN
cord-027654-k0uby99n	218	4	technology	technology	NN
cord-027654-k0uby99n	218	5	for	for	IN
cord-027654-k0uby99n	218	6	poxviruses	poxvirus	NNS
cord-027654-k0uby99n	218	7	is	be	VBZ
cord-027654-k0uby99n	218	8	well	well	RB
cord-027654-k0uby99n	218	9	known	known	JJ
cord-027654-k0uby99n	218	10	,	,	,
cord-027654-k0uby99n	218	11	and	and	CC
cord-027654-k0uby99n	218	12	GMP	GMP	NNP
cord-027654-k0uby99n	218	13	procedures	procedure	NNS
cord-027654-k0uby99n	218	14	for	for	IN
cord-027654-k0uby99n	218	15	amplifi	amplifi	NNP
cord-027654-k0uby99n	218	16	cation	cation	NN
cord-027654-k0uby99n	218	17	of	of	IN
cord-027654-k0uby99n	218	18	these	these	DT
cord-027654-k0uby99n	218	19	viruses	virus	NNS
cord-027654-k0uby99n	218	20	followed	follow	VBD
cord-027654-k0uby99n	218	21	protocols	protocol	NNS
cord-027654-k0uby99n	218	22	similar	similar	JJ
cord-027654-k0uby99n	218	23	to	to	IN
cord-027654-k0uby99n	218	24	those	those	DT
cord-027654-k0uby99n	218	25	developed	develop	VBN
cord-027654-k0uby99n	218	26	for	for	IN
cord-027654-k0uby99n	218	27	vaccinia	vaccinia	NN
cord-027654-k0uby99n	218	28	virus	virus	NN
cord-027654-k0uby99n	218	29	,	,	,
cord-027654-k0uby99n	218	30	the	the	DT
cord-027654-k0uby99n	218	31	path	path	NN
cord-027654-k0uby99n	218	32	into	into	IN
cord-027654-k0uby99n	218	33	clinical	clinical	JJ
cord-027654-k0uby99n	218	34	studies	study	NNS
cord-027654-k0uby99n	218	35	has	have	VBZ
cord-027654-k0uby99n	218	36	been	be	VBN
cord-027654-k0uby99n	218	37	relatively	relatively	RB
cord-027654-k0uby99n	218	38	straightforward	straightforward	JJ
cord-027654-k0uby99n	218	39	,	,	,
cord-027654-k0uby99n	218	40	as	as	IN
cord-027654-k0uby99n	218	41	have	have	VBP
cord-027654-k0uby99n	218	42	the	the	DT
cord-027654-k0uby99n	218	43	several	several	JJ
cord-027654-k0uby99n	218	44	trials	trial	NNS
cord-027654-k0uby99n	218	45	of	of	IN
cord-027654-k0uby99n	218	46	modifi	modifi	NNP
cord-027654-k0uby99n	218	47	ed	ed	NN
cord-027654-k0uby99n	218	48	vaccinia	vaccinia	NN
cord-027654-k0uby99n	218	49	Ankara	Ankara	NNP
cord-027654-k0uby99n	218	50	,	,	,
cord-027654-k0uby99n	218	51	which	which	WDT
cord-027654-k0uby99n	218	52	has	have	VBZ
cord-027654-k0uby99n	218	53	been	be	VBN
cord-027654-k0uby99n	218	54	evaluated	evaluate	VBN
cord-027654-k0uby99n	218	55	both	both	CC
cord-027654-k0uby99n	218	56	as	as	IN
cord-027654-k0uby99n	218	57	a	a	DT
cord-027654-k0uby99n	218	58	vaccine	vaccine	NN
cord-027654-k0uby99n	218	59	for	for	IN
cord-027654-k0uby99n	218	60	HIV	HIV	NNP
cord-027654-k0uby99n	218	61	,	,	,
cord-027654-k0uby99n	218	62	alone	alone	JJ
cord-027654-k0uby99n	218	63	or	or	CC
cord-027654-k0uby99n	218	64	in	in	IN
cord-027654-k0uby99n	218	65	prime	prime	JJ
cord-027654-k0uby99n	218	66	-	-	HYPH
cord-027654-k0uby99n	218	67	boost	boost	NN
cord-027654-k0uby99n	218	68	combinations	combination	NNS
cord-027654-k0uby99n	218	69	,	,	,
cord-027654-k0uby99n	218	70	and	and	CC
cord-027654-k0uby99n	218	71	as	as	IN
cord-027654-k0uby99n	218	72	a	a	DT
cord-027654-k0uby99n	218	73	potentially	potentially	RB
cord-027654-k0uby99n	218	74	safer	safe	JJR
cord-027654-k0uby99n	218	75	next	next	JJ
cord-027654-k0uby99n	218	76	-	-	HYPH
cord-027654-k0uby99n	218	77	generation	generation	NN
cord-027654-k0uby99n	218	78	vaccine	vaccine	NN
cord-027654-k0uby99n	218	79	for	for	IN
cord-027654-k0uby99n	218	80	smallpox	smallpox	NN
cord-027654-k0uby99n	218	81	.	.	.
cord-027654-k0uby99n	219	1	Other	other	JJ
cord-027654-k0uby99n	219	2	129	129	CD
cord-027654-k0uby99n	219	3	and	and	CC
cord-027654-k0uby99n	219	4	a	a	DT
cord-027654-k0uby99n	219	5	DNA	dna	NN
cord-027654-k0uby99n	219	6	vaccine	vaccine	NN
cord-027654-k0uby99n	219	7	for	for	IN
cord-027654-k0uby99n	219	8	infectious	infectious	JJ
cord-027654-k0uby99n	219	9	hematopoietic	hematopoietic	JJ
cord-027654-k0uby99n	219	10	necrosis	necrosis	NN
cord-027654-k0uby99n	219	11	virus	virus	NN
cord-027654-k0uby99n	219	12	,	,	,
cord-027654-k0uby99n	219	13	developed	develop	VBN
cord-027654-k0uby99n	219	14	by	by	IN
cord-027654-k0uby99n	219	15	Merial	Merial	NNP
cord-027654-k0uby99n	219	16	for	for	IN
cord-027654-k0uby99n	219	17	use	use	NN
cord-027654-k0uby99n	219	18	in	in	IN
cord-027654-k0uby99n	219	19	farm	farm	NN
cord-027654-k0uby99n	219	20	-	-	HYPH
cord-027654-k0uby99n	219	21	raised	raise	VBN
cord-027654-k0uby99n	219	22	fi	fi	NN
cord-027654-k0uby99n	219	23	sh	sh	NN
cord-027654-k0uby99n	219	24	.	.	.
cord-027654-k0uby99n	220	1	An	an	DT
cord-027654-k0uby99n	220	2	additional	additional	JJ
cord-027654-k0uby99n	220	3	vaccine	vaccine	NN
cord-027654-k0uby99n	220	4	is	be	VBZ
cord-027654-k0uby99n	220	5	being	be	VBG
cord-027654-k0uby99n	220	6	developed	develop	VBN
cord-027654-k0uby99n	220	7	against	against	IN
cord-027654-k0uby99n	220	8	viral	viral	JJ
cord-027654-k0uby99n	220	9	hemorrhagic	hemorrhagic	JJ
cord-027654-k0uby99n	220	10	septicemia	septicemia	NN
cord-027654-k0uby99n	220	11	virus	virus	NN
cord-027654-k0uby99n	220	12	in	in	IN
cord-027654-k0uby99n	220	13	farmed	farm	VBN
cord-027654-k0uby99n	220	14	salmon	salmon	NN
cord-027654-k0uby99n	220	15	.	.	.
cord-027654-k0uby99n	221	1	In	in	IN
cord-027654-k0uby99n	221	2	these	these	DT
cord-027654-k0uby99n	221	3	studies	study	NNS
cord-027654-k0uby99n	221	4	,	,	,
cord-027654-k0uby99n	221	5	a	a	DT
cord-027654-k0uby99n	221	6	single	single	JJ
cord-027654-k0uby99n	221	7	injection	injection	NN
cord-027654-k0uby99n	221	8	of	of	IN
cord-027654-k0uby99n	221	9	microgram	microgram	NN
cord-027654-k0uby99n	221	10	amounts	amount	NNS
cord-027654-k0uby99n	221	11	of	of	IN
cord-027654-k0uby99n	221	12	DNA	dna	NN
cord-027654-k0uby99n	221	13	induces	induce	VBZ
cord-027654-k0uby99n	221	14	rapid	rapid	JJ
cord-027654-k0uby99n	221	15	and	and	CC
cord-027654-k0uby99n	221	16	long	long	RB
cord-027654-k0uby99n	221	17	-	-	HYPH
cord-027654-k0uby99n	221	18	lasting	last	VBG
cord-027654-k0uby99n	221	19	immune	immune	JJ
cord-027654-k0uby99n	221	20	protection	protection	NN
cord-027654-k0uby99n	221	21	.	.	.
cord-027654-k0uby99n	222	1	130	130	CD
cord-027654-k0uby99n	222	2	A	a	DT
cord-027654-k0uby99n	222	3	recombinant	recombinant	JJ
cord-027654-k0uby99n	222	4	yellow	yellow	JJ
cord-027654-k0uby99n	222	5	fever	fever	NN
cord-027654-k0uby99n	222	6	vaccine	vaccine	NN
cord-027654-k0uby99n	222	7	has	have	VBZ
cord-027654-k0uby99n	222	8	advanced	advance	VBN
cord-027654-k0uby99n	222	9	into	into	IN
cord-027654-k0uby99n	222	10	effi	effi	NNP
cord-027654-k0uby99n	222	11	cacy	cacy	NNP
cord-027654-k0uby99n	222	12	studies	study	NNS
cord-027654-k0uby99n	222	13	as	as	RB
cord-027654-k0uby99n	222	14	well	well	RB
cord-027654-k0uby99n	222	15	.	.	.
cord-027654-k0uby99n	223	1	131	131	CD
cord-027654-k0uby99n	224	1	The	the	DT
cord-027654-k0uby99n	224	2	precedent	precedent	NN
cord-027654-k0uby99n	224	3	set	set	VBN
cord-027654-k0uby99n	224	4	by	by	IN
cord-027654-k0uby99n	224	5	these	these	DT
cord-027654-k0uby99n	224	6	studies	study	NNS
cord-027654-k0uby99n	224	7	provides	provide	VBZ
cord-027654-k0uby99n	224	8	hope	hope	NN
cord-027654-k0uby99n	224	9	that	that	IN
cord-027654-k0uby99n	224	10	additional	additional	JJ
cord-027654-k0uby99n	224	11	gene	gene	NN
cord-027654-k0uby99n	224	12	-	-	HYPH
cord-027654-k0uby99n	224	13	based	base	VBN
cord-027654-k0uby99n	224	14	vaccines	vaccine	NNS
cord-027654-k0uby99n	224	15	will	will	MD
cord-027654-k0uby99n	224	16	become	become	VB
cord-027654-k0uby99n	224	17	available	available	JJ
cord-027654-k0uby99n	224	18	for	for	IN
cord-027654-k0uby99n	224	19	human	human	JJ
cord-027654-k0uby99n	224	20	use	use	NN
cord-027654-k0uby99n	224	21	and	and	CC
cord-027654-k0uby99n	224	22	may	may	MD
cord-027654-k0uby99n	224	23	contribute	contribute	VB
cord-027654-k0uby99n	224	24	to	to	IN
cord-027654-k0uby99n	224	25	the	the	DT
cord-027654-k0uby99n	224	26	development	development	NN
cord-027654-k0uby99n	224	27	of	of	IN
cord-027654-k0uby99n	224	28	protective	protective	JJ
cord-027654-k0uby99n	224	29	immunity	immunity	NN
cord-027654-k0uby99n	224	30	for	for	IN
cord-027654-k0uby99n	224	31	a	a	DT
cord-027654-k0uby99n	224	32	variety	variety	NN
cord-027654-k0uby99n	224	33	of	of	IN
cord-027654-k0uby99n	224	34	challenging	challenge	VBG
cord-027654-k0uby99n	224	35	infectious	infectious	JJ
cord-027654-k0uby99n	224	36	diseases	disease	NNS
cord-027654-k0uby99n	224	37	that	that	WDT
cord-027654-k0uby99n	224	38	have	have	VBP
cord-027654-k0uby99n	224	39	thus	thus	RB
cord-027654-k0uby99n	224	40	far	far	RB
cord-027654-k0uby99n	224	41	eluded	elude	VBN
cord-027654-k0uby99n	224	42	the	the	DT
cord-027654-k0uby99n	224	43	grasp	grasp	NN
cord-027654-k0uby99n	224	44	of	of	IN
cord-027654-k0uby99n	224	45	vaccine	vaccine	NN
cord-027654-k0uby99n	224	46	-	-	HYPH
cord-027654-k0uby99n	224	47	induced	induce	VBN
cord-027654-k0uby99n	224	48	immunity	immunity	NN
cord-027654-k0uby99n	224	49	.	.	.
cord-027654-k0uby99n	224	50	 	 	_SP
cord-027654-k0uby99n	225	1	Major	major	JJ
cord-027654-k0uby99n	225	2	transplantation	transplantation	NN
cord-027654-k0uby99n	225	3	antigens	antigen	NNS
cord-027654-k0uby99n	225	4	,	,	,
cord-027654-k0uby99n	225	5	viruses	virus	NNS
cord-027654-k0uby99n	225	6	,	,	,
cord-027654-k0uby99n	225	7	and	and	CC
cord-027654-k0uby99n	225	8	specifi	specifi	NNP
cord-027654-k0uby99n	225	9	city	city	NN
cord-027654-k0uby99n	225	10	of	of	IN
cord-027654-k0uby99n	225	11	surveillance	surveillance	NN
cord-027654-k0uby99n	225	12	T	t	NN
cord-027654-k0uby99n	225	13	cells	cell	NNS
cord-027654-k0uby99n	225	14	MHC	MHC	NNP
cord-027654-k0uby99n	225	15	-	-	HYPH
cord-027654-k0uby99n	225	16	restricted	restrict	VBN
cord-027654-k0uby99n	225	17	cytotoxic	cytotoxic	JJ
cord-027654-k0uby99n	225	18	T	t	NN
cord-027654-k0uby99n	225	19	cells	cell	NNS
cord-027654-k0uby99n	225	20	:	:	:
cord-027654-k0uby99n	225	21	studies	study	NNS
cord-027654-k0uby99n	225	22	on	on	IN
cord-027654-k0uby99n	225	23	the	the	DT
cord-027654-k0uby99n	225	24	biological	biological	JJ
cord-027654-k0uby99n	225	25	role	role	NN
cord-027654-k0uby99n	225	26	of	of	IN
cord-027654-k0uby99n	225	27	polymorphic	polymorphic	JJ
cord-027654-k0uby99n	225	28	major	major	JJ
cord-027654-k0uby99n	225	29	transplantation	transplantation	NN
cord-027654-k0uby99n	225	30	antigens	antigen	NNS
cord-027654-k0uby99n	225	31	determining	determine	VBG
cord-027654-k0uby99n	225	32	T	t	NN
cord-027654-k0uby99n	225	33	-	-	HYPH
cord-027654-k0uby99n	225	34	cell	cell	NN
cord-027654-k0uby99n	225	35	restriction	restriction	NN
cord-027654-k0uby99n	225	36	-	-	HYPH
cord-027654-k0uby99n	225	37	specifi	specifi	VBN
cord-027654-k0uby99n	225	38	city	city	NN
cord-027654-k0uby99n	225	39	,	,	,
cord-027654-k0uby99n	225	40	function	function	NN
cord-027654-k0uby99n	225	41	,	,	,
cord-027654-k0uby99n	225	42	and	and	CC
cord-027654-k0uby99n	225	43	responsiveness	responsiveness	NN
cord-027654-k0uby99n	225	44	Direct	direct	JJ
cord-027654-k0uby99n	225	45	gene	gene	NN
cord-027654-k0uby99n	225	46	transfer	transfer	NN
cord-027654-k0uby99n	225	47	into	into	IN
cord-027654-k0uby99n	225	48	mouse	mouse	NN
cord-027654-k0uby99n	225	49	muscle	muscle	NN
cord-027654-k0uby99n	225	50	in	in	IN
cord-027654-k0uby99n	225	51	vivo	vivo	NN
cord-027654-k0uby99n	226	1	Heterologous	heterologous	JJ
cord-027654-k0uby99n	226	2	protection	protection	NN
cord-027654-k0uby99n	226	3	against	against	IN
cord-027654-k0uby99n	226	4	infl	infl	NN
cord-027654-k0uby99n	226	5	uenza	uenza	NNP
cord-027654-k0uby99n	226	6	by	by	IN
cord-027654-k0uby99n	226	7	injection	injection	NN
cord-027654-k0uby99n	226	8	of	of	IN
cord-027654-k0uby99n	226	9	DNA	dna	NN
cord-027654-k0uby99n	226	10	encoding	encode	VBG
cord-027654-k0uby99n	226	11	a	a	DT
cord-027654-k0uby99n	226	12	viral	viral	JJ
cord-027654-k0uby99n	226	13	protein	protein	NN
cord-027654-k0uby99n	227	1	A	a	DT
cord-027654-k0uby99n	227	2	human	human	JJ
cord-027654-k0uby99n	227	3	T	t	NN
cord-027654-k0uby99n	227	4	-	-	HYPH
cord-027654-k0uby99n	227	5	cell	cell	NN
cord-027654-k0uby99n	227	6	leukemia	leukemia	NN
cord-027654-k0uby99n	227	7	virus	virus	NN
cord-027654-k0uby99n	227	8	type	type	NN
cord-027654-k0uby99n	227	9	1	1	CD
cord-027654-k0uby99n	227	10	regulatory	regulatory	JJ
cord-027654-k0uby99n	227	11	element	element	NN
cord-027654-k0uby99n	227	12	enhances	enhance	VBZ
cord-027654-k0uby99n	227	13	the	the	DT
cord-027654-k0uby99n	227	14	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	227	15	of	of	IN
cord-027654-k0uby99n	227	16	human	human	JJ
cord-027654-k0uby99n	227	17	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	227	18	ciency	ciency	NNP
cord-027654-k0uby99n	227	19	virus	virus	NN
cord-027654-k0uby99n	227	20	type	type	NN
cord-027654-k0uby99n	227	21	1	1	CD
cord-027654-k0uby99n	227	22	DNA	dna	NN
cord-027654-k0uby99n	227	23	vaccines	vaccine	NNS
cord-027654-k0uby99n	227	24	in	in	IN
cord-027654-k0uby99n	227	25	mice	mouse	NNS
cord-027654-k0uby99n	227	26	and	and	CC
cord-027654-k0uby99n	227	27	nonhuman	nonhuman	NN
cord-027654-k0uby99n	227	28	primates	primate	NNS
cord-027654-k0uby99n	227	29	Genetic	genetic	JJ
cord-027654-k0uby99n	227	30	immunization	immunization	NN
cord-027654-k0uby99n	227	31	is	be	VBZ
cord-027654-k0uby99n	227	32	a	a	DT
cord-027654-k0uby99n	227	33	simple	simple	JJ
cord-027654-k0uby99n	227	34	method	method	NN
cord-027654-k0uby99n	227	35	for	for	IN
cord-027654-k0uby99n	227	36	eliciting	elicit	VBG
cord-027654-k0uby99n	227	37	an	an	DT
cord-027654-k0uby99n	227	38	immune	immune	JJ
cord-027654-k0uby99n	227	39	response	response	NN
cord-027654-k0uby99n	227	40	DNA	dna	NN
cord-027654-k0uby99n	227	41	inoculation	inoculation	NN
cord-027654-k0uby99n	227	42	induces	induce	VBZ
cord-027654-k0uby99n	227	43	protective	protective	JJ
cord-027654-k0uby99n	227	44	in	in	IN
cord-027654-k0uby99n	227	45	vivo	vivo	NN
cord-027654-k0uby99n	227	46	immune	immune	JJ
cord-027654-k0uby99n	227	47	responses	response	NNS
cord-027654-k0uby99n	227	48	against	against	IN
cord-027654-k0uby99n	227	49	cellular	cellular	JJ
cord-027654-k0uby99n	227	50	challenge	challenge	NN
cord-027654-k0uby99n	227	51	with	with	IN
cord-027654-k0uby99n	227	52	HIV-1	HIV-1	NNP
cord-027654-k0uby99n	227	53	antigen	antigen	NN
cord-027654-k0uby99n	227	54	-	-	HYPH
cord-027654-k0uby99n	227	55	expressing	express	VBG
cord-027654-k0uby99n	227	56	cells	cell	NNS
cord-027654-k0uby99n	227	57	Vaccination	vaccination	NN
cord-027654-k0uby99n	227	58	of	of	IN
cord-027654-k0uby99n	227	59	mice	mouse	NNS
cord-027654-k0uby99n	227	60	and	and	CC
cord-027654-k0uby99n	227	61	nonhuman	nonhuman	NN
cord-027654-k0uby99n	227	62	primates	primate	NNS
cord-027654-k0uby99n	227	63	using	use	VBG
cord-027654-k0uby99n	227	64	HIV	HIV	NNP
cord-027654-k0uby99n	227	65	-	-	HYPH
cord-027654-k0uby99n	227	66	gene	gene	NN
cord-027654-k0uby99n	227	67	-	-	HYPH
cord-027654-k0uby99n	227	68	containing	contain	VBG
cord-027654-k0uby99n	227	69	DNA	DNA	NNP
cord-027654-k0uby99n	227	70	Circumventing	circumvent	VBG
cord-027654-k0uby99n	227	71	genetic	genetic	JJ
cord-027654-k0uby99n	227	72	restriction	restriction	NN
cord-027654-k0uby99n	227	73	of	of	IN
cord-027654-k0uby99n	227	74	protection	protection	NN
cord-027654-k0uby99n	227	75	against	against	IN
cord-027654-k0uby99n	227	76	malaria	malaria	NN
cord-027654-k0uby99n	227	77	with	with	IN
cord-027654-k0uby99n	227	78	multigene	multigene	JJ
cord-027654-k0uby99n	227	79	DNA	DNA	NNP
cord-027654-k0uby99n	227	80	immunization	immunization	NN
cord-027654-k0uby99n	227	81	:	:	:
cord-027654-k0uby99n	227	82	CD8	CD8	NNP
cord-027654-k0uby99n	227	83	+	+	CC
cord-027654-k0uby99n	227	84	cell-	cell-	NN
cord-027654-k0uby99n	227	85	,	,	,
cord-027654-k0uby99n	227	86	interferon	interferon	NN
cord-027654-k0uby99n	227	87	gamma-	gamma-	JJ
cord-027654-k0uby99n	227	88	,	,	,
cord-027654-k0uby99n	227	89	and	and	CC
cord-027654-k0uby99n	227	90	nitric	nitric	JJ
cord-027654-k0uby99n	227	91	oxide	oxide	NN
cord-027654-k0uby99n	227	92	-	-	HYPH
cord-027654-k0uby99n	227	93	dependent	dependent	JJ
cord-027654-k0uby99n	227	94	immunity	immunity	NN
cord-027654-k0uby99n	227	95	DNA	dna	NN
cord-027654-k0uby99n	227	96	vaccines	vaccine	NNS
cord-027654-k0uby99n	227	97	against	against	IN
cord-027654-k0uby99n	227	98	malaria	malaria	NN
cord-027654-k0uby99n	227	99	:	:	:
cord-027654-k0uby99n	227	100	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	227	101	and	and	CC
cord-027654-k0uby99n	227	102	protection	protection	NN
cord-027654-k0uby99n	227	103	in	in	IN
cord-027654-k0uby99n	227	104	a	a	DT
cord-027654-k0uby99n	227	105	rodent	rodent	NN
cord-027654-k0uby99n	227	106	model	model	NN
cord-027654-k0uby99n	227	107	Protection	Protection	NNP
cord-027654-k0uby99n	227	108	of	of	IN
cord-027654-k0uby99n	227	109	mice	mouse	NNS
cord-027654-k0uby99n	227	110	against	against	IN
cord-027654-k0uby99n	227	111	Plasmodium	Plasmodium	NNP
cord-027654-k0uby99n	227	112	yoelii	yoelii	NN
cord-027654-k0uby99n	227	113	sporozoite	sporozoite	NNP
cord-027654-k0uby99n	227	114	challenge	challenge	NN
cord-027654-k0uby99n	227	115	with	with	IN
cord-027654-k0uby99n	227	116	P.	P.	NNP
cord-027654-k0uby99n	227	117	yoelii	yoelii	NNP
cord-027654-k0uby99n	227	118	merozoite	merozoite	NNP
cord-027654-k0uby99n	227	119	surface	surface	NN
cord-027654-k0uby99n	227	120	protein	protein	NN
cord-027654-k0uby99n	227	121	1	1	CD
cord-027654-k0uby99n	227	122	DNA	dna	NN
cord-027654-k0uby99n	227	123	vaccines	vaccine	NNS
cord-027654-k0uby99n	227	124	Vaccination	vaccination	NN
cord-027654-k0uby99n	227	125	against	against	IN
cord-027654-k0uby99n	227	126	tuberculosis	tuberculosis	NN
cord-027654-k0uby99n	227	127	by	by	IN
cord-027654-k0uby99n	227	128	injection	injection	NN
cord-027654-k0uby99n	227	129	Immunization	Immunization	NNP
cord-027654-k0uby99n	227	130	for	for	IN
cord-027654-k0uby99n	227	131	Ebola	Ebola	NNP
cord-027654-k0uby99n	227	132	virus	virus	NN
cord-027654-k0uby99n	227	133	infection	infection	NN
cord-027654-k0uby99n	227	134	Overcoming	overcome	VBG
cord-027654-k0uby99n	227	135	immunity	immunity	NN
cord-027654-k0uby99n	227	136	to	to	IN
cord-027654-k0uby99n	227	137	a	a	DT
cord-027654-k0uby99n	227	138	viral	viral	JJ
cord-027654-k0uby99n	227	139	vaccine	vaccine	NN
cord-027654-k0uby99n	227	140	by	by	IN
cord-027654-k0uby99n	227	141	DNA	dna	NN
cord-027654-k0uby99n	227	142	priming	priming	NN
cord-027654-k0uby99n	227	143	before	before	IN
cord-027654-k0uby99n	227	144	vector	vector	NN
cord-027654-k0uby99n	227	145	boosting	boost	VBG
cord-027654-k0uby99n	227	146	Plasmid	Plasmid	NNP
cord-027654-k0uby99n	227	147	chemokines	chemokine	NNS
cord-027654-k0uby99n	227	148	and	and	CC
cord-027654-k0uby99n	227	149	colony	colony	NN
cord-027654-k0uby99n	227	150	-	-	HYPH
cord-027654-k0uby99n	227	151	stimulating	stimulate	VBG
cord-027654-k0uby99n	227	152	factors	factor	NNS
cord-027654-k0uby99n	227	153	enhance	enhance	VBP
cord-027654-k0uby99n	227	154	the	the	DT
cord-027654-k0uby99n	227	155	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	227	156	of	of	IN
cord-027654-k0uby99n	227	157	DNA	dna	NN
cord-027654-k0uby99n	227	158	priming	priming	NN
cord-027654-k0uby99n	227	159	-	-	HYPH
cord-027654-k0uby99n	227	160	viral	viral	JJ
cord-027654-k0uby99n	227	161	vector	vector	NN
cord-027654-k0uby99n	227	162	boosting	boost	VBG
cord-027654-k0uby99n	227	163	human	human	JJ
cord-027654-k0uby99n	227	164	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	227	165	ciency	ciency	NNP
cord-027654-k0uby99n	227	166	virus	virus	NN
cord-027654-k0uby99n	227	167	type	type	NN
cord-027654-k0uby99n	227	168	1	1	CD
cord-027654-k0uby99n	227	169	vaccines	vaccine	NNS
cord-027654-k0uby99n	227	170	Comparative	comparative	JJ
cord-027654-k0uby99n	227	171	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	227	172	in	in	IN
cord-027654-k0uby99n	227	173	rhesus	rhesu	NNS
cord-027654-k0uby99n	227	174	monkeys	monkey	NNS
cord-027654-k0uby99n	227	175	of	of	IN
cord-027654-k0uby99n	227	176	DNA	dna	NN
cord-027654-k0uby99n	227	177	plasmid	plasmid	NN
cord-027654-k0uby99n	227	178	,	,	,
cord-027654-k0uby99n	227	179	recombinant	recombinant	JJ
cord-027654-k0uby99n	227	180	vaccinia	vaccinia	NN
cord-027654-k0uby99n	227	181	virus	virus	NN
cord-027654-k0uby99n	227	182	,	,	,
cord-027654-k0uby99n	227	183	and	and	CC
cord-027654-k0uby99n	227	184	replication	replication	NN
cord-027654-k0uby99n	227	185	-	-	HYPH
cord-027654-k0uby99n	227	186	defective	defective	JJ
cord-027654-k0uby99n	227	187	adenovirus	adenovirus	NN
cord-027654-k0uby99n	227	188	vectors	vector	NNS
cord-027654-k0uby99n	227	189	expressing	express	VBG
cord-027654-k0uby99n	227	190	a	a	DT
cord-027654-k0uby99n	227	191	human	human	JJ
cord-027654-k0uby99n	227	192	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	227	193	ciency	ciency	NNP
cord-027654-k0uby99n	227	194	virus	virus	NN
cord-027654-k0uby99n	227	195	type	type	NN
cord-027654-k0uby99n	227	196	1	1	CD
cord-027654-k0uby99n	227	197	gag	gag	NN
cord-027654-k0uby99n	227	198	gene	gene	NN
cord-027654-k0uby99n	227	199	Development	Development	NNP
cord-027654-k0uby99n	227	200	of	of	IN
cord-027654-k0uby99n	227	201	an	an	DT
cord-027654-k0uby99n	227	202	HIV-1	HIV-1	NNP
cord-027654-k0uby99n	227	203	vaccine	vaccine	NN
cord-027654-k0uby99n	227	204	based	base	VBN
cord-027654-k0uby99n	227	205	on	on	IN
cord-027654-k0uby99n	227	206	replication	replication	NN
cord-027654-k0uby99n	227	207	-	-	HYPH
cord-027654-k0uby99n	227	208	defective	defective	JJ
cord-027654-k0uby99n	227	209	adenovirus	adenovirus	NN
cord-027654-k0uby99n	227	210	.	.	.
cord-027654-k0uby99n	228	1	Presented	present	VBN
cord-027654-k0uby99n	228	2	at	at	IN
cord-027654-k0uby99n	228	3	the	the	DT
cord-027654-k0uby99n	228	4	Keystone	Keystone	NNP
cord-027654-k0uby99n	228	5	Symposium	Symposium	NNP
cord-027654-k0uby99n	228	6	on	on	IN
cord-027654-k0uby99n	228	7	HIV	HIV	NNP
cord-027654-k0uby99n	228	8	Vaccine	Vaccine	NNP
cord-027654-k0uby99n	228	9	Development	Development	NNP
cord-027654-k0uby99n	228	10	Impact	Impact	NNP
cord-027654-k0uby99n	228	11	of	of	IN
cord-027654-k0uby99n	228	12	pre	pre	JJ
cord-027654-k0uby99n	228	13	-	-	JJ
cord-027654-k0uby99n	228	14	existing	existing	JJ
cord-027654-k0uby99n	228	15	immunity	immunity	NN
cord-027654-k0uby99n	228	16	on	on	IN
cord-027654-k0uby99n	228	17	the	the	DT
cord-027654-k0uby99n	228	18	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	228	19	of	of	IN
cord-027654-k0uby99n	228	20	Ad5-based	ad5-based	JJ
cord-027654-k0uby99n	228	21	vaccines	vaccine	NNS
cord-027654-k0uby99n	228	22	.	.	.
cord-027654-k0uby99n	229	1	Presented	present	VBN
cord-027654-k0uby99n	229	2	at	at	IN
cord-027654-k0uby99n	229	3	AIDS	AIDS	NNP
cord-027654-k0uby99n	230	1	Vaccines	vaccine	NNS
cord-027654-k0uby99n	230	2	Oral	oral	JJ
cord-027654-k0uby99n	230	3	vaccination	vaccination	NN
cord-027654-k0uby99n	230	4	of	of	IN
cord-027654-k0uby99n	230	5	mice	mouse	NNS
cord-027654-k0uby99n	230	6	with	with	IN
cord-027654-k0uby99n	230	7	adenoviral	adenoviral	JJ
cord-027654-k0uby99n	230	8	vectors	vector	NNS
cord-027654-k0uby99n	230	9	is	be	VBZ
cord-027654-k0uby99n	230	10	not	not	RB
cord-027654-k0uby99n	230	11	impaired	impair	VBN
cord-027654-k0uby99n	230	12	by	by	IN
cord-027654-k0uby99n	230	13	preexisting	preexist	VBG
cord-027654-k0uby99n	230	14	immunity	immunity	NN
cord-027654-k0uby99n	230	15	to	to	IN
cord-027654-k0uby99n	230	16	the	the	DT
cord-027654-k0uby99n	230	17	vaccine	vaccine	NN
cord-027654-k0uby99n	230	18	carrier	carrier	NN
cord-027654-k0uby99n	230	19	Enhanced	Enhanced	NNP
cord-027654-k0uby99n	230	20	mucosal	mucosal	JJ
cord-027654-k0uby99n	230	21	immunoglobulin	immunoglobulin	NN
cord-027654-k0uby99n	230	22	A	a	DT
cord-027654-k0uby99n	230	23	response	response	NN
cord-027654-k0uby99n	230	24	of	of	IN
cord-027654-k0uby99n	230	25	intranasal	intranasal	NNP
cord-027654-k0uby99n	230	26	adenoviral	adenoviral	NNP
cord-027654-k0uby99n	230	27	vector	vector	NNP
cord-027654-k0uby99n	230	28	human	human	NNP
cord-027654-k0uby99n	230	29	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	230	30	ciency	ciency	NNP
cord-027654-k0uby99n	230	31	virus	virus	NNP
cord-027654-k0uby99n	230	32	vaccine	vaccine	NN
cord-027654-k0uby99n	230	33	and	and	CC
cord-027654-k0uby99n	230	34	localization	localization	NN
cord-027654-k0uby99n	230	35	in	in	IN
cord-027654-k0uby99n	230	36	the	the	DT
cord-027654-k0uby99n	230	37	central	central	JJ
cord-027654-k0uby99n	230	38	nervous	nervous	JJ
cord-027654-k0uby99n	230	39	system	system	NN
cord-027654-k0uby99n	230	40	PEGylation	pegylation	NN
cord-027654-k0uby99n	230	41	of	of	IN
cord-027654-k0uby99n	230	42	adenovirus	adenovirus	NN
cord-027654-k0uby99n	230	43	with	with	IN
cord-027654-k0uby99n	230	44	retention	retention	NN
cord-027654-k0uby99n	230	45	of	of	IN
cord-027654-k0uby99n	230	46	infectivity	infectivity	NN
cord-027654-k0uby99n	230	47	and	and	CC
cord-027654-k0uby99n	230	48	protection	protection	NN
cord-027654-k0uby99n	230	49	from	from	IN
cord-027654-k0uby99n	230	50	neutralizing	neutralize	VBG
cord-027654-k0uby99n	230	51	antibody	antibody	NN
cord-027654-k0uby99n	230	52	in	in	IN
cord-027654-k0uby99n	230	53	vitro	vitro	FW
cord-027654-k0uby99n	230	54	and	and	CC
cord-027654-k0uby99n	230	55	in	in	IN
cord-027654-k0uby99n	230	56	vivo	vivo	NNP
cord-027654-k0uby99n	230	57	Adenovirus	Adenovirus	NNP
cord-027654-k0uby99n	230	58	type	type	NN
cord-027654-k0uby99n	230	59	5	5	CD
cord-027654-k0uby99n	230	60	and	and	CC
cord-027654-k0uby99n	230	61	7	7	CD
cord-027654-k0uby99n	230	62	capsid	capsid	NN
cord-027654-k0uby99n	230	63	chimera	chimera	NN
cord-027654-k0uby99n	230	64	:	:	:
cord-027654-k0uby99n	230	65	fi	fi	NNP
cord-027654-k0uby99n	230	66	ber	ber	NNP
cord-027654-k0uby99n	230	67	replacement	replacement	NN
cord-027654-k0uby99n	230	68	alters	alter	VBZ
cord-027654-k0uby99n	230	69	receptor	receptor	NN
cord-027654-k0uby99n	230	70	tropism	tropism	NN
cord-027654-k0uby99n	230	71	without	without	IN
cord-027654-k0uby99n	230	72	affecting	affect	VBG
cord-027654-k0uby99n	230	73	primary	primary	JJ
cord-027654-k0uby99n	230	74	immune	immune	JJ
cord-027654-k0uby99n	230	75	neutralization	neutralization	NN
cord-027654-k0uby99n	230	76	epitopes	epitope	NNS
cord-027654-k0uby99n	231	1	Improved	improved	JJ
cord-027654-k0uby99n	231	2	adenovirus	adenovirus	NN
cord-027654-k0uby99n	231	3	vectors	vector	NNS
cord-027654-k0uby99n	231	4	for	for	IN
cord-027654-k0uby99n	231	5	infection	infection	NN
cord-027654-k0uby99n	231	6	of	of	IN
cord-027654-k0uby99n	231	7	cardiovascular	cardiovascular	JJ
cord-027654-k0uby99n	231	8	tissues	tissue	NNS
cord-027654-k0uby99n	231	9	Exploiting	exploit	VBG
cord-027654-k0uby99n	231	10	the	the	DT
cord-027654-k0uby99n	231	11	natural	natural	JJ
cord-027654-k0uby99n	231	12	diversity	diversity	NN
cord-027654-k0uby99n	231	13	in	in	IN
cord-027654-k0uby99n	231	14	adenovirus	adenovirus	NN
cord-027654-k0uby99n	231	15	tropism	tropism	NN
cord-027654-k0uby99n	231	16	for	for	IN
cord-027654-k0uby99n	231	17	therapy	therapy	NN
cord-027654-k0uby99n	231	18	and	and	CC
cord-027654-k0uby99n	231	19	prevention	prevention	NN
cord-027654-k0uby99n	231	20	of	of	IN
cord-027654-k0uby99n	231	21	disease	disease	NN
cord-027654-k0uby99n	232	1	An	an	DT
cord-027654-k0uby99n	232	2	adenoviral	adenoviral	JJ
cord-027654-k0uby99n	232	3	type	type	NN
cord-027654-k0uby99n	232	4	5	5	CD
cord-027654-k0uby99n	232	5	vector	vector	NN
cord-027654-k0uby99n	232	6	carrying	carry	VBG
cord-027654-k0uby99n	232	7	a	a	DT
cord-027654-k0uby99n	232	8	type	type	NN
cord-027654-k0uby99n	232	9	35	35	CD
cord-027654-k0uby99n	232	10	fi	fi	NN
cord-027654-k0uby99n	232	11	ber	ber	NNP
cord-027654-k0uby99n	232	12	as	as	IN
cord-027654-k0uby99n	232	13	a	a	DT
cord-027654-k0uby99n	232	14	vaccine	vaccine	NN
cord-027654-k0uby99n	232	15	vehicle	vehicle	NN
cord-027654-k0uby99n	232	16	:	:	:
cord-027654-k0uby99n	232	17	DC	DC	NNP
cord-027654-k0uby99n	232	18	targeting	targeting	NN
cord-027654-k0uby99n	232	19	,	,	,
cord-027654-k0uby99n	232	20	cross	cross	NN
cord-027654-k0uby99n	232	21	neutralization	neutralization	NN
cord-027654-k0uby99n	232	22	,	,	,
cord-027654-k0uby99n	232	23	and	and	CC
cord-027654-k0uby99n	232	24	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	232	25	Circumvention	circumvention	NN
cord-027654-k0uby99n	232	26	of	of	IN
cord-027654-k0uby99n	232	27	immunity	immunity	NN
cord-027654-k0uby99n	232	28	to	to	IN
cord-027654-k0uby99n	232	29	the	the	DT
cord-027654-k0uby99n	232	30	adenovirus	adenovirus	NN
cord-027654-k0uby99n	232	31	major	major	JJ
cord-027654-k0uby99n	232	32	coat	coat	NN
cord-027654-k0uby99n	232	33	protein	protein	NN
cord-027654-k0uby99n	232	34	hexon	hexon	NNP
cord-027654-k0uby99n	232	35	Construction	construction	NN
cord-027654-k0uby99n	232	36	and	and	CC
cord-027654-k0uby99n	232	37	characterization	characterization	NN
cord-027654-k0uby99n	232	38	of	of	IN
cord-027654-k0uby99n	232	39	hexonchimeric	hexonchimeric	JJ
cord-027654-k0uby99n	232	40	adenoviruses	adenovirus	NNS
cord-027654-k0uby99n	232	41	:	:	:
cord-027654-k0uby99n	232	42	specifi	specifi	NNP
cord-027654-k0uby99n	232	43	cation	cation	NN
cord-027654-k0uby99n	232	44	of	of	IN
cord-027654-k0uby99n	232	45	adenovirus	adenovirus	NN
cord-027654-k0uby99n	232	46	serotype	serotype	NN
cord-027654-k0uby99n	232	47	Circumventing	circumvent	VBG
cord-027654-k0uby99n	232	48	the	the	DT
cord-027654-k0uby99n	232	49	immune	immune	JJ
cord-027654-k0uby99n	232	50	response	response	NN
cord-027654-k0uby99n	232	51	to	to	IN
cord-027654-k0uby99n	232	52	adenovirus	adenovirus	NN
cord-027654-k0uby99n	232	53	-	-	HYPH
cord-027654-k0uby99n	232	54	mediated	mediate	VBN
cord-027654-k0uby99n	232	55	gene	gene	NN
cord-027654-k0uby99n	232	56	therapy	therapy	NN
cord-027654-k0uby99n	232	57	Seroswitch	Seroswitch	NNP
cord-027654-k0uby99n	232	58	'	'	POS
cord-027654-k0uby99n	232	59	adenovirus	adenovirus	NN
cord-027654-k0uby99n	232	60	-	-	HYPH
cord-027654-k0uby99n	232	61	mediated	mediate	VBN
cord-027654-k0uby99n	232	62	in	in	IN
cord-027654-k0uby99n	232	63	vivo	vivo	NN
cord-027654-k0uby99n	232	64	gene	gene	NN
cord-027654-k0uby99n	232	65	transfer	transfer	NN
cord-027654-k0uby99n	232	66	:	:	:
cord-027654-k0uby99n	232	67	circumvention	circumvention	NN
cord-027654-k0uby99n	232	68	of	of	IN
cord-027654-k0uby99n	232	69	anti	anti	JJ
cord-027654-k0uby99n	232	70	-	-	JJ
cord-027654-k0uby99n	232	71	adenovirus	adenovirus	JJ
cord-027654-k0uby99n	232	72	humoral	humoral	JJ
cord-027654-k0uby99n	232	73	immune	immune	JJ
cord-027654-k0uby99n	232	74	defenses	defense	NNS
cord-027654-k0uby99n	232	75	against	against	IN
cord-027654-k0uby99n	232	76	repeat	repeat	NN
cord-027654-k0uby99n	232	77	adenovirus	adenovirus	NN
cord-027654-k0uby99n	232	78	vector	vector	NN
cord-027654-k0uby99n	232	79	administration	administration	NN
cord-027654-k0uby99n	232	80	by	by	IN
cord-027654-k0uby99n	232	81	changing	change	VBG
cord-027654-k0uby99n	232	82	the	the	DT
cord-027654-k0uby99n	232	83	adenovirus	adenovirus	NN
cord-027654-k0uby99n	232	84	serotype	serotype	NN
cord-027654-k0uby99n	232	85	Circumvention	circumvention	NN
cord-027654-k0uby99n	232	86	of	of	IN
cord-027654-k0uby99n	232	87	anti	anti	JJ
cord-027654-k0uby99n	232	88	-	-	JJ
cord-027654-k0uby99n	232	89	adenovirus	adenovirus	JJ
cord-027654-k0uby99n	232	90	neutralizing	neutralize	VBG
cord-027654-k0uby99n	232	91	immunity	immunity	NN
cord-027654-k0uby99n	232	92	by	by	IN
cord-027654-k0uby99n	232	93	administration	administration	NN
cord-027654-k0uby99n	232	94	of	of	IN
cord-027654-k0uby99n	232	95	an	an	DT
cord-027654-k0uby99n	232	96	adenoviral	adenoviral	JJ
cord-027654-k0uby99n	232	97	vector	vector	NN
cord-027654-k0uby99n	232	98	of	of	IN
cord-027654-k0uby99n	232	99	an	an	DT
cord-027654-k0uby99n	232	100	alternate	alternate	JJ
cord-027654-k0uby99n	232	101	serotype	serotype	NN
cord-027654-k0uby99n	232	102	Replication	replication	NN
cord-027654-k0uby99n	232	103	-	-	HYPH
cord-027654-k0uby99n	232	104	defi	defi	NNP
cord-027654-k0uby99n	232	105	cient	cient	NNP
cord-027654-k0uby99n	232	106	human	human	JJ
cord-027654-k0uby99n	232	107	adenovirus	adenovirus	NN
cord-027654-k0uby99n	232	108	type	type	NN
cord-027654-k0uby99n	232	109	35	35	CD
cord-027654-k0uby99n	232	110	vectors	vector	NNS
cord-027654-k0uby99n	232	111	for	for	IN
cord-027654-k0uby99n	232	112	gene	gene	NN
cord-027654-k0uby99n	232	113	transfer	transfer	NN
cord-027654-k0uby99n	232	114	and	and	CC
cord-027654-k0uby99n	232	115	vaccination	vaccination	NN
cord-027654-k0uby99n	232	116	:	:	:
cord-027654-k0uby99n	232	117	effi	effi	NNP
cord-027654-k0uby99n	232	118	cient	cient	NNP
cord-027654-k0uby99n	232	119	human	human	JJ
cord-027654-k0uby99n	232	120	cell	cell	NN
cord-027654-k0uby99n	232	121	infection	infection	NN
cord-027654-k0uby99n	232	122	and	and	CC
cord-027654-k0uby99n	232	123	bypass	bypass	NN
cord-027654-k0uby99n	232	124	of	of	IN
cord-027654-k0uby99n	232	125	preexisting	preexist	VBG
cord-027654-k0uby99n	232	126	adenovirus	adenovirus	NN
cord-027654-k0uby99n	232	127	immunity	immunity	NN
cord-027654-k0uby99n	232	128	Immunogenicity	Immunogenicity	NNP
cord-027654-k0uby99n	232	129	of	of	IN
cord-027654-k0uby99n	232	130	recombinant	recombinant	JJ
cord-027654-k0uby99n	232	131	adenovirus	adenovirus	NN
cord-027654-k0uby99n	232	132	serotype	serotype	NN
cord-027654-k0uby99n	232	133	35	35	CD
cord-027654-k0uby99n	232	134	vaccine	vaccine	NN
cord-027654-k0uby99n	232	135	in	in	IN
cord-027654-k0uby99n	232	136	the	the	DT
cord-027654-k0uby99n	232	137	presence	presence	NN
cord-027654-k0uby99n	232	138	of	of	IN
cord-027654-k0uby99n	232	139	preexisting	preexist	VBG
cord-027654-k0uby99n	232	140	anti	anti	JJ
cord-027654-k0uby99n	232	141	-	-	JJ
cord-027654-k0uby99n	232	142	Ad5	ad5	JJ
cord-027654-k0uby99n	232	143	immunity	immunity	NN
cord-027654-k0uby99n	232	144	Immunogenicity	Immunogenicity	NNP
cord-027654-k0uby99n	232	145	of	of	IN
cord-027654-k0uby99n	232	146	heterologous	heterologous	JJ
cord-027654-k0uby99n	232	147	adenovirus	adenovirus	NN
cord-027654-k0uby99n	232	148	prime	prime	JJ
cord-027654-k0uby99n	232	149	-	-	HYPH
cord-027654-k0uby99n	232	150	boost	boost	NN
cord-027654-k0uby99n	232	151	regimens	regimen	NNS
cord-027654-k0uby99n	232	152	involving	involve	VBG
cord-027654-k0uby99n	232	153	Ad11	Ad11	NNP
cord-027654-k0uby99n	233	1	and	and	CC
cord-027654-k0uby99n	233	2	Ad35	Ad35	NNP
cord-027654-k0uby99n	233	3	.	.	.
cord-027654-k0uby99n	234	1	Presented	present	VBN
cord-027654-k0uby99n	234	2	at	at	IN
cord-027654-k0uby99n	234	3	AIDS	AIDS	NNP
cord-027654-k0uby99n	234	4	Vaccines	Vaccines	NNPS
cord-027654-k0uby99n	234	5	Protection	Protection	NNP
cord-027654-k0uby99n	234	6	against	against	IN
cord-027654-k0uby99n	234	7	mucosal	mucosal	JJ
cord-027654-k0uby99n	234	8	simian	simian	JJ
cord-027654-k0uby99n	234	9	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	234	10	ciency	ciency	NNP
cord-027654-k0uby99n	234	11	virus	virus	NN
cord-027654-k0uby99n	235	1	SIV(mac251	SIV(mac251	NNP
cord-027654-k0uby99n	235	2	)	)	-RRB-
cord-027654-k0uby99n	235	3	challenge	challenge	NN
cord-027654-k0uby99n	235	4	by	by	IN
cord-027654-k0uby99n	235	5	using	use	VBG
cord-027654-k0uby99n	235	6	replicating	replicate	VBG
cord-027654-k0uby99n	235	7	adenovirus	adenovirus	NN
cord-027654-k0uby99n	235	8	-	-	HYPH
cord-027654-k0uby99n	235	9	SIV	SIV	NNP
cord-027654-k0uby99n	235	10	multigene	multigene	JJ
cord-027654-k0uby99n	235	11	vaccine	vaccine	NN
cord-027654-k0uby99n	235	12	priming	priming	NN
cord-027654-k0uby99n	235	13	and	and	CC
cord-027654-k0uby99n	235	14	subunit	subunit	NN
cord-027654-k0uby99n	235	15	boosting	boost	VBG
cord-027654-k0uby99n	235	16	Live	live	JJ
cord-027654-k0uby99n	235	17	recombinant	recombinant	JJ
cord-027654-k0uby99n	235	18	vectors	vector	NNS
cord-027654-k0uby99n	235	19	for	for	IN
cord-027654-k0uby99n	235	20	AIDS	AIDS	NNP
cord-027654-k0uby99n	235	21	vaccine	vaccine	NN
cord-027654-k0uby99n	235	22	development	development	NN
cord-027654-k0uby99n	235	23	Ovine	ovine	JJ
cord-027654-k0uby99n	235	24	adenovirus	adenovirus	NN
cord-027654-k0uby99n	235	25	vectors	vector	NNS
cord-027654-k0uby99n	235	26	overcome	overcome	VBP
cord-027654-k0uby99n	235	27	preexisting	preexist	VBG
cord-027654-k0uby99n	235	28	humoral	humoral	JJ
cord-027654-k0uby99n	235	29	immunity	immunity	NN
cord-027654-k0uby99n	235	30	against	against	IN
cord-027654-k0uby99n	235	31	human	human	JJ
cord-027654-k0uby99n	235	32	adenoviruses	adenovirus	NNS
cord-027654-k0uby99n	235	33	in	in	IN
cord-027654-k0uby99n	235	34	vivo	vivo	NNP
cord-027654-k0uby99n	235	35	Replication	replication	NN
cord-027654-k0uby99n	235	36	-	-	HYPH
cord-027654-k0uby99n	235	37	defective	defective	JJ
cord-027654-k0uby99n	235	38	bovine	bovine	JJ
cord-027654-k0uby99n	235	39	adenovirus	adenovirus	NN
cord-027654-k0uby99n	235	40	type	type	NN
cord-027654-k0uby99n	235	41	3	3	CD
cord-027654-k0uby99n	235	42	as	as	IN
cord-027654-k0uby99n	235	43	an	an	DT
cord-027654-k0uby99n	235	44	expression	expression	NN
cord-027654-k0uby99n	235	45	vector	vector	NN
cord-027654-k0uby99n	235	46	Porcine	Porcine	NNP
cord-027654-k0uby99n	235	47	adenovirus-3	adenovirus-3	NNP
cord-027654-k0uby99n	235	48	as	as	IN
cord-027654-k0uby99n	235	49	a	a	DT
cord-027654-k0uby99n	235	50	helper	helper	NN
cord-027654-k0uby99n	235	51	-	-	HYPH
cord-027654-k0uby99n	235	52	dependent	dependent	JJ
cord-027654-k0uby99n	235	53	expression	expression	NN
cord-027654-k0uby99n	235	54	vector	vector	NN
cord-027654-k0uby99n	235	55	Replicationdefective	Replicationdefective	NNP
cord-027654-k0uby99n	235	56	vector	vector	NN
cord-027654-k0uby99n	235	57	based	base	VBN
cord-027654-k0uby99n	235	58	on	on	IN
cord-027654-k0uby99n	235	59	a	a	DT
cord-027654-k0uby99n	235	60	chimpanzee	chimpanzee	NN
cord-027654-k0uby99n	235	61	adenovirus	adenovirus	NN
cord-027654-k0uby99n	235	62	Construction	construction	NN
cord-027654-k0uby99n	235	63	and	and	CC
cord-027654-k0uby99n	235	64	characterization	characterization	NN
cord-027654-k0uby99n	235	65	of	of	IN
cord-027654-k0uby99n	235	66	recombinant	recombinant	JJ
cord-027654-k0uby99n	235	67	porcine	porcine	JJ
cord-027654-k0uby99n	235	68	adenovirus	adenovirus	NN
cord-027654-k0uby99n	235	69	serotype	serotype	NN
cord-027654-k0uby99n	235	70	5	5	CD
cord-027654-k0uby99n	235	71	expressing	express	VBG
cord-027654-k0uby99n	235	72	the	the	DT
cord-027654-k0uby99n	235	73	transmissible	transmissible	JJ
cord-027654-k0uby99n	235	74	gastroenteritis	gastroenteritis	NN
cord-027654-k0uby99n	235	75	virus	virus	NN
cord-027654-k0uby99n	235	76	spike	spike	NN
cord-027654-k0uby99n	235	77	gene	gene	NN
cord-027654-k0uby99n	235	78	Novel	novel	NN
cord-027654-k0uby99n	235	79	,	,	,
cord-027654-k0uby99n	235	80	chimpanzee	chimpanzee	NN
cord-027654-k0uby99n	235	81	serotype	serotype	NN
cord-027654-k0uby99n	235	82	68-based	68-based	CD
cord-027654-k0uby99n	235	83	adenoviral	adenoviral	NNP
cord-027654-k0uby99n	235	84	vaccine	vaccine	NN
cord-027654-k0uby99n	235	85	carrier	carrier	NN
cord-027654-k0uby99n	235	86	for	for	IN
cord-027654-k0uby99n	235	87	induction	induction	NN
cord-027654-k0uby99n	235	88	of	of	IN
cord-027654-k0uby99n	235	89	antibodies	antibody	NNS
cord-027654-k0uby99n	235	90	to	to	IN
cord-027654-k0uby99n	235	91	a	a	DT
cord-027654-k0uby99n	235	92	transgene	transgene	NN
cord-027654-k0uby99n	235	93	product	product	NN
cord-027654-k0uby99n	235	94	Complications	complication	NNS
cord-027654-k0uby99n	235	95	of	of	IN
cord-027654-k0uby99n	235	96	smallpox	smallpox	NN
cord-027654-k0uby99n	235	97	vaccination	vaccination	NN
cord-027654-k0uby99n	235	98	Disseminated	disseminate	VBD
cord-027654-k0uby99n	235	99	vaccinia	vaccinia	NN
cord-027654-k0uby99n	235	100	in	in	IN
cord-027654-k0uby99n	235	101	a	a	DT
cord-027654-k0uby99n	235	102	military	military	JJ
cord-027654-k0uby99n	235	103	recruit	recruit	NN
cord-027654-k0uby99n	235	104	with	with	IN
cord-027654-k0uby99n	235	105	human	human	JJ
cord-027654-k0uby99n	235	106	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	235	107	ciency	ciency	NNP
cord-027654-k0uby99n	235	108	virus	virus	NN
cord-027654-k0uby99n	235	109	(	(	-LRB-
cord-027654-k0uby99n	235	110	HIV	HIV	NNP
cord-027654-k0uby99n	235	111	)	)	-RRB-
cord-027654-k0uby99n	235	112	disease	disease	NN
cord-027654-k0uby99n	235	113	Smallpox	Smallpox	NNP
cord-027654-k0uby99n	235	114	and	and	CC
cord-027654-k0uby99n	235	115	Its	-PRON-	PRP$
cord-027654-k0uby99n	235	116	Eradication	eradication	NN
cord-027654-k0uby99n	235	117	.	.	.
cord-027654-k0uby99n	236	1	World	World	NNP
cord-027654-k0uby99n	236	2	Health	Health	NNP
cord-027654-k0uby99n	236	3	Organization	Organization	NNP
cord-027654-k0uby99n	236	4	Live	live	VB
cord-027654-k0uby99n	236	5	attenuated	attenuated	JJ
cord-027654-k0uby99n	236	6	vaccinia	vaccinia	NN
cord-027654-k0uby99n	236	7	and	and	CC
cord-027654-k0uby99n	236	8	other	other	JJ
cord-027654-k0uby99n	236	9	poxviruses	poxvirus	NNS
cord-027654-k0uby99n	236	10	as	as	IN
cord-027654-k0uby99n	236	11	delivery	delivery	NN
cord-027654-k0uby99n	236	12	systems	system	NNS
cord-027654-k0uby99n	236	13	:	:	:
cord-027654-k0uby99n	237	1	public	public	JJ
cord-027654-k0uby99n	237	2	health	health	NN
cord-027654-k0uby99n	237	3	issues	issue	NNS
cord-027654-k0uby99n	237	4	NYVAC	NYVAC	NNP
cord-027654-k0uby99n	237	5	:	:	:
cord-027654-k0uby99n	237	6	a	a	DT
cord-027654-k0uby99n	237	7	highly	highly	RB
cord-027654-k0uby99n	237	8	attenuated	attenuated	JJ
cord-027654-k0uby99n	237	9	strain	strain	NN
cord-027654-k0uby99n	237	10	of	of	IN
cord-027654-k0uby99n	237	11	vaccinia	vaccinia	NN
cord-027654-k0uby99n	237	12	virus	virus	NN
cord-027654-k0uby99n	237	13	Safety	safety	NN
cord-027654-k0uby99n	237	14	and	and	CC
cord-027654-k0uby99n	237	15	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	237	16	of	of	IN
cord-027654-k0uby99n	237	17	recombinants	recombinant	NNS
cord-027654-k0uby99n	237	18	based	base	VBN
cord-027654-k0uby99n	237	19	on	on	IN
cord-027654-k0uby99n	237	20	the	the	DT
cord-027654-k0uby99n	237	21	genetically	genetically	RB
cord-027654-k0uby99n	237	22	-	-	HYPH
cord-027654-k0uby99n	237	23	engineered	engineer	VBN
cord-027654-k0uby99n	237	24	vaccinia	vaccinia	NN
cord-027654-k0uby99n	237	25	strain	strain	NN
cord-027654-k0uby99n	237	26	Poxvirus	Poxvirus	NNP
cord-027654-k0uby99n	237	27	-	-	HYPH
cord-027654-k0uby99n	237	28	based	base	VBN
cord-027654-k0uby99n	237	29	vectors	vector	NNS
cord-027654-k0uby99n	237	30	as	as	IN
cord-027654-k0uby99n	237	31	vaccine	vaccine	NN
cord-027654-k0uby99n	237	32	candidates	candidate	NNS
cord-027654-k0uby99n	237	33	p53	p53	VBP
cord-027654-k0uby99n	237	34	as	as	IN
cord-027654-k0uby99n	237	35	a	a	DT
cord-027654-k0uby99n	237	36	target	target	NN
cord-027654-k0uby99n	237	37	for	for	IN
cord-027654-k0uby99n	237	38	cancer	cancer	NN
cord-027654-k0uby99n	237	39	vaccines	vaccine	NNS
cord-027654-k0uby99n	237	40	:	:	:
cord-027654-k0uby99n	237	41	recombinant	recombinant	JJ
cord-027654-k0uby99n	237	42	canarypox	canarypox	NN
cord-027654-k0uby99n	237	43	virus	virus	NN
cord-027654-k0uby99n	237	44	vectors	vector	NNS
cord-027654-k0uby99n	237	45	expressing	express	VBG
cord-027654-k0uby99n	237	46	p53	p53	NN
cord-027654-k0uby99n	237	47	protect	protect	JJ
cord-027654-k0uby99n	237	48	mice	mouse	NNS
cord-027654-k0uby99n	237	49	against	against	IN
cord-027654-k0uby99n	237	50	lethal	lethal	JJ
cord-027654-k0uby99n	237	51	tumor	tumor	NN
cord-027654-k0uby99n	237	52	cell	cell	NN
cord-027654-k0uby99n	237	53	challenge	challenge	NN
cord-027654-k0uby99n	237	54	Poxvirus	Poxvirus	NNP
cord-027654-k0uby99n	237	55	-	-	HYPH
cord-027654-k0uby99n	237	56	based	base	VBN
cord-027654-k0uby99n	237	57	vaccine	vaccine	NN
cord-027654-k0uby99n	237	58	candidates	candidate	NNS
cord-027654-k0uby99n	237	59	for	for	IN
cord-027654-k0uby99n	237	60	cancer	cancer	NN
cord-027654-k0uby99n	237	61	,	,	,
cord-027654-k0uby99n	237	62	AIDS	AIDS	NNP
cord-027654-k0uby99n	237	63	,	,	,
cord-027654-k0uby99n	237	64	and	and	CC
cord-027654-k0uby99n	237	65	other	other	JJ
cord-027654-k0uby99n	237	66	infectious	infectious	JJ
cord-027654-k0uby99n	237	67	diseases	disease	NNS
cord-027654-k0uby99n	238	1	Applications	application	NNS
cord-027654-k0uby99n	238	2	of	of	IN
cord-027654-k0uby99n	238	3	pox	pox	NN
cord-027654-k0uby99n	238	4	virus	virus	NN
cord-027654-k0uby99n	238	5	vectors	vector	NNS
cord-027654-k0uby99n	238	6	to	to	IN
cord-027654-k0uby99n	238	7	vaccination	vaccination	NN
cord-027654-k0uby99n	238	8	:	:	:
cord-027654-k0uby99n	238	9	an	an	DT
cord-027654-k0uby99n	238	10	update	update	NN
cord-027654-k0uby99n	238	11	Highly	highly	RB
cord-027654-k0uby99n	238	12	attenuated	attenuate	VBN
cord-027654-k0uby99n	238	13	poxvirus	poxvirus	NN
cord-027654-k0uby99n	238	14	vectors	vector	NNS
cord-027654-k0uby99n	238	15	Immunisation	Immunisation	NNP
cord-027654-k0uby99n	238	16	with	with	IN
cord-027654-k0uby99n	238	17	canarypox	canarypox	NN
cord-027654-k0uby99n	238	18	virus	virus	NN
cord-027654-k0uby99n	238	19	expressing	express	VBG
cord-027654-k0uby99n	238	20	rabies	rabies	NN
cord-027654-k0uby99n	238	21	glycoprotein	glycoprotein	NN
cord-027654-k0uby99n	238	22	Genetically	genetically	RB
cord-027654-k0uby99n	238	23	engineered	engineer	VBN
cord-027654-k0uby99n	238	24	poxviruses	poxvirus	NNS
cord-027654-k0uby99n	238	25	for	for	IN
cord-027654-k0uby99n	238	26	recombinant	recombinant	JJ
cord-027654-k0uby99n	238	27	gene	gene	NN
cord-027654-k0uby99n	238	28	expression	expression	NN
cord-027654-k0uby99n	238	29	,	,	,
cord-027654-k0uby99n	238	30	vaccination	vaccination	NN
cord-027654-k0uby99n	238	31	,	,	,
cord-027654-k0uby99n	238	32	and	and	CC
cord-027654-k0uby99n	238	33	safety	safety	NN
cord-027654-k0uby99n	238	34	Vaccine	vaccine	NN
cord-027654-k0uby99n	238	35	therapy	therapy	NN
cord-027654-k0uby99n	238	36	in	in	IN
cord-027654-k0uby99n	238	37	early	early	JJ
cord-027654-k0uby99n	238	38	HIV-1	HIV-1	NNP
cord-027654-k0uby99n	238	39	infection	infection	NN
cord-027654-k0uby99n	238	40	using	use	VBG
cord-027654-k0uby99n	238	41	a	a	DT
cord-027654-k0uby99n	238	42	recombinant	recombinant	JJ
cord-027654-k0uby99n	238	43	canarypox	canarypox	NN
cord-027654-k0uby99n	238	44	virus	virus	NN
cord-027654-k0uby99n	238	45	expressing	express	VBG
cord-027654-k0uby99n	238	46	gp160MN	gp160mn	XX
cord-027654-k0uby99n	238	47	(	(	-LRB-
cord-027654-k0uby99n	238	48	ALVAC	ALVAC	NNP
cord-027654-k0uby99n	238	49	-	-	HYPH
cord-027654-k0uby99n	238	50	HIV	HIV	NNP
cord-027654-k0uby99n	238	51	)	)	-RRB-
cord-027654-k0uby99n	238	52	:	:	:
cord-027654-k0uby99n	238	53	a	a	DT
cord-027654-k0uby99n	238	54	double	double	JJ
cord-027654-k0uby99n	238	55	-	-	HYPH
cord-027654-k0uby99n	238	56	blind	blind	JJ
cord-027654-k0uby99n	238	57	controlled	control	VBN
cord-027654-k0uby99n	238	58	randomized	randomized	JJ
cord-027654-k0uby99n	238	59	study	study	NN
cord-027654-k0uby99n	238	60	of	of	IN
cord-027654-k0uby99n	238	61	safety	safety	NN
cord-027654-k0uby99n	238	62	and	and	CC
cord-027654-k0uby99n	238	63	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	239	1	Canarypox	Canarypox	NNP
cord-027654-k0uby99n	239	2	virus	virus	NN
cord-027654-k0uby99n	239	3	-	-	HYPH
cord-027654-k0uby99n	239	4	based	base	VBN
cord-027654-k0uby99n	239	5	vaccines	vaccine	NNS
cord-027654-k0uby99n	239	6	:	:	:
cord-027654-k0uby99n	239	7	prime	prime	JJ
cord-027654-k0uby99n	239	8	-	-	HYPH
cord-027654-k0uby99n	239	9	boost	boost	NN
cord-027654-k0uby99n	239	10	strategies	strategy	NNS
cord-027654-k0uby99n	239	11	to	to	TO
cord-027654-k0uby99n	239	12	induce	induce	VB
cord-027654-k0uby99n	239	13	cell	cell	NN
cord-027654-k0uby99n	239	14	-	-	HYPH
cord-027654-k0uby99n	239	15	mediated	mediate	VBN
cord-027654-k0uby99n	239	16	and	and	CC
cord-027654-k0uby99n	239	17	humoral	humoral	JJ
cord-027654-k0uby99n	239	18	immunity	immunity	NN
cord-027654-k0uby99n	239	19	against	against	IN
cord-027654-k0uby99n	239	20	HIV	HIV	NNP
cord-027654-k0uby99n	239	21	Gene	Gene	NNP
cord-027654-k0uby99n	239	22	gun	gun	NN
cord-027654-k0uby99n	239	23	intradermal	intradermal	JJ
cord-027654-k0uby99n	239	24	DNA	dna	NN
cord-027654-k0uby99n	239	25	immunization	immunization	NN
cord-027654-k0uby99n	239	26	followed	follow	VBN
cord-027654-k0uby99n	239	27	by	by	IN
cord-027654-k0uby99n	239	28	boosting	boost	VBG
cord-027654-k0uby99n	239	29	with	with	IN
cord-027654-k0uby99n	239	30	modifi	modifi	NNP
cord-027654-k0uby99n	239	31	ed	ed	NN
cord-027654-k0uby99n	239	32	vaccinia	vaccinia	NN
cord-027654-k0uby99n	239	33	virus	virus	NN
cord-027654-k0uby99n	239	34	Ankara	Ankara	NNP
cord-027654-k0uby99n	239	35	:	:	:
cord-027654-k0uby99n	239	36	enhanced	enhance	VBN
cord-027654-k0uby99n	239	37	CD8	CD8	NNP
cord-027654-k0uby99n	239	38	+	+	CC
cord-027654-k0uby99n	239	39	T	t	NN
cord-027654-k0uby99n	239	40	cell	cell	NN
cord-027654-k0uby99n	239	41	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	239	42	and	and	CC
cord-027654-k0uby99n	239	43	protective	protective	JJ
cord-027654-k0uby99n	239	44	effi	effi	NNP
cord-027654-k0uby99n	239	45	cacy	cacy	NN
cord-027654-k0uby99n	239	46	in	in	IN
cord-027654-k0uby99n	239	47	the	the	DT
cord-027654-k0uby99n	239	48	infl	infl	NNP
cord-027654-k0uby99n	239	49	uenza	uenza	NNP
cord-027654-k0uby99n	239	50	and	and	CC
cord-027654-k0uby99n	239	51	malaria	malaria	NN
cord-027654-k0uby99n	239	52	models	model	NNS
cord-027654-k0uby99n	239	53	A	a	DT
cord-027654-k0uby99n	239	54	group	group	NN
cord-027654-k0uby99n	239	55	specifi	specifi	NNP
cord-027654-k0uby99n	239	56	c	c	NNP
cord-027654-k0uby99n	239	57	anamnestic	anamnestic	NNP
cord-027654-k0uby99n	239	58	immune	immune	JJ
cord-027654-k0uby99n	239	59	reaction	reaction	NN
cord-027654-k0uby99n	239	60	against	against	IN
cord-027654-k0uby99n	239	61	HIV-1	HIV-1	NNP
cord-027654-k0uby99n	239	62	induced	induce	VBN
cord-027654-k0uby99n	239	63	by	by	IN
cord-027654-k0uby99n	239	64	a	a	DT
cord-027654-k0uby99n	239	65	candidate	candidate	NN
cord-027654-k0uby99n	239	66	vaccine	vaccine	NN
cord-027654-k0uby99n	239	67	against	against	IN
cord-027654-k0uby99n	239	68	AIDS	AIDS	NNP
cord-027654-k0uby99n	239	69	Poxvirus	Poxvirus	NNP
cord-027654-k0uby99n	239	70	-	-	HYPH
cord-027654-k0uby99n	239	71	based	base	VBN
cord-027654-k0uby99n	239	72	vectors	vector	NNS
cord-027654-k0uby99n	239	73	as	as	IN
cord-027654-k0uby99n	239	74	vaccine	vaccine	NN
cord-027654-k0uby99n	239	75	candidates	candidate	NNS
cord-027654-k0uby99n	239	76	Vaccination	vaccination	NN
cord-027654-k0uby99n	239	77	of	of	IN
cord-027654-k0uby99n	239	78	vaccinia	vaccinia	NN
cord-027654-k0uby99n	239	79	-	-	HYPH
cord-027654-k0uby99n	239	80	naive	naive	JJ
cord-027654-k0uby99n	239	81	adults	adult	NNS
cord-027654-k0uby99n	239	82	with	with	IN
cord-027654-k0uby99n	239	83	human	human	JJ
cord-027654-k0uby99n	239	84	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	239	85	ciency	ciency	NNP
cord-027654-k0uby99n	239	86	virus	virus	NN
cord-027654-k0uby99n	239	87	type	type	NN
cord-027654-k0uby99n	239	88	1	1	CD
cord-027654-k0uby99n	239	89	gp160	gp160	NNP
cord-027654-k0uby99n	239	90	recombinant	recombinant	JJ
cord-027654-k0uby99n	239	91	vaccinia	vaccinia	NN
cord-027654-k0uby99n	239	92	virus	virus	NN
cord-027654-k0uby99n	239	93	in	in	IN
cord-027654-k0uby99n	239	94	a	a	DT
cord-027654-k0uby99n	239	95	blinded	blind	VBN
cord-027654-k0uby99n	239	96	,	,	,
cord-027654-k0uby99n	239	97	controlled	control	VBN
cord-027654-k0uby99n	239	98	,	,	,
cord-027654-k0uby99n	239	99	randomized	randomized	JJ
cord-027654-k0uby99n	239	100	clinical	clinical	JJ
cord-027654-k0uby99n	239	101	trial	trial	NN
cord-027654-k0uby99n	239	102	.	.	.
cord-027654-k0uby99n	240	1	The	the	DT
cord-027654-k0uby99n	240	2	AIDS	AIDS	NNP
cord-027654-k0uby99n	240	3	Vaccine	Vaccine	NNP
cord-027654-k0uby99n	240	4	Clinical	Clinical	NNP
cord-027654-k0uby99n	240	5	Trials	Trials	NNPS
cord-027654-k0uby99n	240	6	Network	Network	NNP
cord-027654-k0uby99n	240	7	Potential	potential	JJ
cord-027654-k0uby99n	240	8	improvement	improvement	NN
cord-027654-k0uby99n	240	9	for	for	IN
cord-027654-k0uby99n	240	10	poxvirus	poxvirus	NNP
cord-027654-k0uby99n	240	11	-	-	HYPH
cord-027654-k0uby99n	240	12	based	base	VBN
cord-027654-k0uby99n	240	13	immunizations	immunization	NNS
cord-027654-k0uby99n	240	14	vehicles	vehicle	NNS
cord-027654-k0uby99n	240	15	Multienvelope	Multienvelope	NNP
cord-027654-k0uby99n	240	16	HIV	HIV	NNP
cord-027654-k0uby99n	240	17	vaccine	vaccine	NN
cord-027654-k0uby99n	240	18	safety	safety	NN
cord-027654-k0uby99n	240	19	and	and	CC
cord-027654-k0uby99n	240	20	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	240	21	in	in	IN
cord-027654-k0uby99n	240	22	small	small	JJ
cord-027654-k0uby99n	240	23	animals	animal	NNS
cord-027654-k0uby99n	240	24	and	and	CC
cord-027654-k0uby99n	240	25	chimpanzees	chimpanzee	NNS
cord-027654-k0uby99n	240	26	Containment	Containment	NNP
cord-027654-k0uby99n	240	27	of	of	IN
cord-027654-k0uby99n	240	28	simian	simian	JJ
cord-027654-k0uby99n	240	29	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	240	30	ciency	ciency	NNP
cord-027654-k0uby99n	240	31	virus	virus	NN
cord-027654-k0uby99n	240	32	infection	infection	NN
cord-027654-k0uby99n	240	33	in	in	IN
cord-027654-k0uby99n	240	34	vaccinated	vaccinate	VBN
cord-027654-k0uby99n	240	35	macaques	macaque	NNS
cord-027654-k0uby99n	240	36	:	:	:
cord-027654-k0uby99n	240	37	correlation	correlation	NN
cord-027654-k0uby99n	240	38	with	with	IN
cord-027654-k0uby99n	240	39	the	the	DT
cord-027654-k0uby99n	240	40	magnitude	magnitude	NN
cord-027654-k0uby99n	240	41	of	of	IN
cord-027654-k0uby99n	240	42	virus	virus	NN
cord-027654-k0uby99n	240	43	-	-	HYPH
cord-027654-k0uby99n	240	44	specifi	specifi	VBN
cord-027654-k0uby99n	240	45	c	c	NN
cord-027654-k0uby99n	240	46	pre	pre	JJ
cord-027654-k0uby99n	240	47	-	-	JJ
cord-027654-k0uby99n	240	48	and	and	CC
cord-027654-k0uby99n	240	49	postchallenge	postchallenge	NNP
cord-027654-k0uby99n	240	50	CD4	CD4	NNP
cord-027654-k0uby99n	240	51	+	+	CC
cord-027654-k0uby99n	240	52	and	and	CC
cord-027654-k0uby99n	240	53	CD8	CD8	NNP
cord-027654-k0uby99n	240	54	+	+	CC
cord-027654-k0uby99n	240	55	T	T	NNP
cord-027654-k0uby99n	240	56	cell	cell	NN
cord-027654-k0uby99n	240	57	responses	response	NNS
cord-027654-k0uby99n	240	58	Largescale	largescale	JJ
cord-027654-k0uby99n	240	59	production	production	NN
cord-027654-k0uby99n	240	60	and	and	CC
cord-027654-k0uby99n	240	61	purifi	purifi	NNP
cord-027654-k0uby99n	240	62	cation	cation	NN
cord-027654-k0uby99n	240	63	of	of	IN
cord-027654-k0uby99n	240	64	a	a	DT
cord-027654-k0uby99n	240	65	vaccinia	vaccinia	NN
cord-027654-k0uby99n	240	66	recombinant	recombinant	NN
cord-027654-k0uby99n	240	67	-	-	HYPH
cord-027654-k0uby99n	240	68	derived	derive	VBN
cord-027654-k0uby99n	240	69	HIV-1	HIV-1	NNP
cord-027654-k0uby99n	240	70	gp160	gp160	NNP
cord-027654-k0uby99n	240	71	and	and	CC
cord-027654-k0uby99n	240	72	analysis	analysis	NN
cord-027654-k0uby99n	240	73	of	of	IN
cord-027654-k0uby99n	240	74	its	-PRON-	PRP$
cord-027654-k0uby99n	240	75	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	240	76	Removal	Removal	NNP
cord-027654-k0uby99n	240	77	of	of	IN
cord-027654-k0uby99n	240	78	cryptic	cryptic	JJ
cord-027654-k0uby99n	240	79	poxvirus	poxvirus	NNP
cord-027654-k0uby99n	240	80	transcription	transcription	NN
cord-027654-k0uby99n	240	81	termination	termination	NN
cord-027654-k0uby99n	240	82	signals	signal	NNS
cord-027654-k0uby99n	240	83	from	from	IN
cord-027654-k0uby99n	240	84	the	the	DT
cord-027654-k0uby99n	240	85	human	human	JJ
cord-027654-k0uby99n	240	86	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	240	87	ciency	ciency	NNP
cord-027654-k0uby99n	240	88	virus	virus	NN
cord-027654-k0uby99n	240	89	type	type	NN
cord-027654-k0uby99n	240	90	1	1	CD
cord-027654-k0uby99n	240	91	envelope	envelope	NN
cord-027654-k0uby99n	240	92	gene	gene	NN
cord-027654-k0uby99n	240	93	enhances	enhance	VBZ
cord-027654-k0uby99n	240	94	expression	expression	NN
cord-027654-k0uby99n	240	95	and	and	CC
cord-027654-k0uby99n	240	96	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	240	97	of	of	IN
cord-027654-k0uby99n	240	98	a	a	DT
cord-027654-k0uby99n	240	99	recombinant	recombinant	JJ
cord-027654-k0uby99n	240	100	vaccinia	vaccinia	NN
cord-027654-k0uby99n	240	101	virus	virus	NN
cord-027654-k0uby99n	240	102	Recombinant	recombinant	JJ
cord-027654-k0uby99n	240	103	virus	virus	NN
cord-027654-k0uby99n	240	104	vaccine	vaccine	NN
cord-027654-k0uby99n	240	105	-	-	HYPH
cord-027654-k0uby99n	240	106	induced	induce	VBN
cord-027654-k0uby99n	240	107	SIV	SIV	NNP
cord-027654-k0uby99n	240	108	-	-	HYPH
cord-027654-k0uby99n	240	109	specifi	specifi	NNP
cord-027654-k0uby99n	241	1	c	c	LS
cord-027654-k0uby99n	241	2	CD8	CD8	NNP
cord-027654-k0uby99n	241	3	+	+	CC
cord-027654-k0uby99n	241	4	cytotoxic	cytotoxic	JJ
cord-027654-k0uby99n	241	5	T	t	NN
cord-027654-k0uby99n	241	6	lymphocytes	lymphocyte	NNS
cord-027654-k0uby99n	241	7	Immunization	immunization	NN
cord-027654-k0uby99n	241	8	with	with	IN
cord-027654-k0uby99n	241	9	a	a	DT
cord-027654-k0uby99n	241	10	modifi	modifi	NN
cord-027654-k0uby99n	241	11	ed	ed	NN
cord-027654-k0uby99n	241	12	vaccinia	vaccinia	NN
cord-027654-k0uby99n	241	13	virus	virus	NN
cord-027654-k0uby99n	241	14	expressing	express	VBG
cord-027654-k0uby99n	241	15	simian	simian	JJ
cord-027654-k0uby99n	241	16	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	241	17	ciency	ciency	NNP
cord-027654-k0uby99n	241	18	virus	virus	NN
cord-027654-k0uby99n	241	19	(	(	-LRB-
cord-027654-k0uby99n	241	20	SIV	SIV	NNP
cord-027654-k0uby99n	241	21	)	)	-RRB-
cord-027654-k0uby99n	241	22	Gag	Gag	NNP
cord-027654-k0uby99n	241	23	-	-	HYPH
cord-027654-k0uby99n	241	24	Pol	pol	NN
cord-027654-k0uby99n	241	25	primes	prime	NNS
cord-027654-k0uby99n	241	26	for	for	IN
cord-027654-k0uby99n	241	27	an	an	DT
cord-027654-k0uby99n	241	28	anamnestic	anamnestic	JJ
cord-027654-k0uby99n	241	29	Gag	gag	NN
cord-027654-k0uby99n	241	30	-	-	HYPH
cord-027654-k0uby99n	241	31	specifi	specifi	NNP
cord-027654-k0uby99n	241	32	c	c	NN
cord-027654-k0uby99n	241	33	cytotoxic	cytotoxic	JJ
cord-027654-k0uby99n	241	34	T	t	NN
cord-027654-k0uby99n	241	35	-	-	HYPH
cord-027654-k0uby99n	241	36	lymphocyte	lymphocyte	NN
cord-027654-k0uby99n	241	37	response	response	NN
cord-027654-k0uby99n	241	38	and	and	CC
cord-027654-k0uby99n	241	39	is	be	VBZ
cord-027654-k0uby99n	241	40	associated	associate	VBN
cord-027654-k0uby99n	241	41	with	with	IN
cord-027654-k0uby99n	241	42	reduction	reduction	NN
cord-027654-k0uby99n	241	43	of	of	IN
cord-027654-k0uby99n	241	44	viremia	viremia	NN
cord-027654-k0uby99n	241	45	after	after	IN
cord-027654-k0uby99n	241	46	SIV	SIV	NNP
cord-027654-k0uby99n	241	47	challenge	challenge	NN
cord-027654-k0uby99n	241	48	Reduction	reduction	NN
cord-027654-k0uby99n	241	49	of	of	IN
cord-027654-k0uby99n	241	50	simian	simian	JJ
cord-027654-k0uby99n	241	51	-	-	HYPH
cord-027654-k0uby99n	241	52	human	human	JJ
cord-027654-k0uby99n	241	53	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	241	54	ciency	ciency	NNP
cord-027654-k0uby99n	241	55	virus	virus	NN
cord-027654-k0uby99n	241	56	89.6P	89.6p	CD
cord-027654-k0uby99n	241	57	viremia	viremia	NN
cord-027654-k0uby99n	241	58	in	in	IN
cord-027654-k0uby99n	241	59	rhesus	rhesu	NNS
cord-027654-k0uby99n	241	60	monkeys	monkey	NNS
cord-027654-k0uby99n	241	61	by	by	IN
cord-027654-k0uby99n	241	62	recombinant	recombinant	JJ
cord-027654-k0uby99n	241	63	modifi	modifi	NNP
cord-027654-k0uby99n	241	64	ed	ed	NN
cord-027654-k0uby99n	241	65	vaccinia	vaccinia	NN
cord-027654-k0uby99n	241	66	virus	virus	NN
cord-027654-k0uby99n	241	67	Ankara	Ankara	NNP
cord-027654-k0uby99n	241	68	vaccination	vaccination	NN
cord-027654-k0uby99n	242	1	Enhanced	enhanced	JJ
cord-027654-k0uby99n	242	2	simian	simian	JJ
cord-027654-k0uby99n	242	3	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	242	4	ciency	ciency	NNP
cord-027654-k0uby99n	242	5	virusspecifi	virusspecifi	NNP
cord-027654-k0uby99n	242	6	c	c	NNP
cord-027654-k0uby99n	242	7	immune	immune	JJ
cord-027654-k0uby99n	242	8	responses	response	NNS
cord-027654-k0uby99n	242	9	in	in	IN
cord-027654-k0uby99n	242	10	macaques	macaque	NNS
cord-027654-k0uby99n	242	11	induced	induce	VBN
cord-027654-k0uby99n	242	12	by	by	IN
cord-027654-k0uby99n	242	13	priming	prime	VBG
cord-027654-k0uby99n	242	14	with	with	IN
cord-027654-k0uby99n	242	15	recombinant	recombinant	JJ
cord-027654-k0uby99n	242	16	Semliki	Semliki	NNP
cord-027654-k0uby99n	242	17	Forest	Forest	NNP
cord-027654-k0uby99n	242	18	virus	virus	NN
cord-027654-k0uby99n	242	19	and	and	CC
cord-027654-k0uby99n	242	20	boosting	boost	VBG
cord-027654-k0uby99n	242	21	with	with	IN
cord-027654-k0uby99n	242	22	modifi	modifi	NNP
cord-027654-k0uby99n	242	23	ed	ed	NN
cord-027654-k0uby99n	242	24	vaccinia	vaccinia	NN
cord-027654-k0uby99n	242	25	virus	virus	NN
cord-027654-k0uby99n	242	26	Ankara	Ankara	NNP
cord-027654-k0uby99n	242	27	Effect	Effect	NNP
cord-027654-k0uby99n	242	28	of	of	IN
cord-027654-k0uby99n	242	29	vaccination	vaccination	NN
cord-027654-k0uby99n	242	30	with	with	IN
cord-027654-k0uby99n	242	31	recombinant	recombinant	JJ
cord-027654-k0uby99n	242	32	modifi	modifi	NNP
cord-027654-k0uby99n	242	33	ed	ed	NN
cord-027654-k0uby99n	242	34	vaccinia	vaccinia	NN
cord-027654-k0uby99n	242	35	virus	virus	NN
cord-027654-k0uby99n	242	36	Ankara	Ankara	NNP
cord-027654-k0uby99n	242	37	expressing	express	VBG
cord-027654-k0uby99n	242	38	structural	structural	JJ
cord-027654-k0uby99n	242	39	and	and	CC
cord-027654-k0uby99n	242	40	regulatory	regulatory	JJ
cord-027654-k0uby99n	242	41	genes	gene	NNS
cord-027654-k0uby99n	242	42	of	of	IN
cord-027654-k0uby99n	242	43	SIV(macJ5	SIV(macJ5	NNP
cord-027654-k0uby99n	242	44	)	)	-RRB-
cord-027654-k0uby99n	242	45	on	on	IN
cord-027654-k0uby99n	242	46	the	the	DT
cord-027654-k0uby99n	242	47	kinetics	kinetic	NNS
cord-027654-k0uby99n	242	48	of	of	IN
cord-027654-k0uby99n	242	49	SIV	SIV	NNP
cord-027654-k0uby99n	242	50	replication	replication	NN
cord-027654-k0uby99n	242	51	in	in	IN
cord-027654-k0uby99n	242	52	cynomolgus	cynomolgus	JJ
cord-027654-k0uby99n	242	53	monkeys	monkey	NNS
cord-027654-k0uby99n	242	54	Induction	Induction	NNP
cord-027654-k0uby99n	242	55	of	of	IN
cord-027654-k0uby99n	242	56	simian	simian	JJ
cord-027654-k0uby99n	242	57	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	242	58	ciency	ciency	NNP
cord-027654-k0uby99n	242	59	virus	virus	NN
cord-027654-k0uby99n	242	60	(	(	-LRB-
cord-027654-k0uby99n	242	61	SIV)-specifi	SIV)-specifi	NNP
cord-027654-k0uby99n	242	62	c	c	NN
cord-027654-k0uby99n	242	63	CTL	CTL	NNP
cord-027654-k0uby99n	242	64	in	in	IN
cord-027654-k0uby99n	242	65	rhesus	rhesus	NN
cord-027654-k0uby99n	242	66	macaques	macaque	NNS
cord-027654-k0uby99n	242	67	by	by	IN
cord-027654-k0uby99n	242	68	vaccination	vaccination	NN
cord-027654-k0uby99n	242	69	with	with	IN
cord-027654-k0uby99n	242	70	modifi	modifi	NNP
cord-027654-k0uby99n	242	71	ed	ed	NNP
cord-027654-k0uby99n	242	72	vaccinia	vaccinia	NN
cord-027654-k0uby99n	242	73	virus	virus	NN
cord-027654-k0uby99n	242	74	Ankara	Ankara	NNP
cord-027654-k0uby99n	242	75	expressing	express	VBG
cord-027654-k0uby99n	242	76	SIV	SIV	NNP
cord-027654-k0uby99n	242	77	transgenes	transgene	NNS
cord-027654-k0uby99n	242	78	:	:	:
cord-027654-k0uby99n	242	79	infl	infl	NNP
cord-027654-k0uby99n	242	80	uence	uence	NN
cord-027654-k0uby99n	242	81	of	of	IN
cord-027654-k0uby99n	242	82	preexisting	preexist	VBG
cord-027654-k0uby99n	242	83	anti	anti	JJ
cord-027654-k0uby99n	242	84	-	-	JJ
cord-027654-k0uby99n	242	85	vector	vector	JJ
cord-027654-k0uby99n	242	86	immunity	immunity	NN
cord-027654-k0uby99n	242	87	Comparison	comparison	NN
cord-027654-k0uby99n	242	88	of	of	IN
cord-027654-k0uby99n	242	89	vaccine	vaccine	NN
cord-027654-k0uby99n	242	90	strategies	strategy	NNS
cord-027654-k0uby99n	242	91	using	use	VBG
cord-027654-k0uby99n	242	92	recombinant	recombinant	JJ
cord-027654-k0uby99n	242	93	env	env	NN
cord-027654-k0uby99n	242	94	-	-	HYPH
cord-027654-k0uby99n	242	95	gag	gag	NN
cord-027654-k0uby99n	242	96	-	-	HYPH
cord-027654-k0uby99n	242	97	pol	pol	NN
cord-027654-k0uby99n	242	98	MVA	MVA	NNP
cord-027654-k0uby99n	242	99	with	with	IN
cord-027654-k0uby99n	242	100	or	or	CC
cord-027654-k0uby99n	242	101	without	without	IN
cord-027654-k0uby99n	242	102	an	an	DT
cord-027654-k0uby99n	242	103	oligomeric	oligomeric	JJ
cord-027654-k0uby99n	242	104	Env	Env	NNP
cord-027654-k0uby99n	242	105	protein	protein	NN
cord-027654-k0uby99n	242	106	boost	boost	NN
cord-027654-k0uby99n	242	107	in	in	IN
cord-027654-k0uby99n	242	108	the	the	DT
cord-027654-k0uby99n	242	109	SHIV	SHIV	NNP
cord-027654-k0uby99n	242	110	rhesus	rhesu	NNS
cord-027654-k0uby99n	242	111	macaque	macaque	NN
cord-027654-k0uby99n	242	112	model	model	NN
cord-027654-k0uby99n	242	113	Immunogenicity	Immunogenicity	NNP
cord-027654-k0uby99n	242	114	and	and	CC
cord-027654-k0uby99n	242	115	protective	protective	JJ
cord-027654-k0uby99n	242	116	effi	effi	NNP
cord-027654-k0uby99n	242	117	cacy	cacy	NN
cord-027654-k0uby99n	242	118	of	of	IN
cord-027654-k0uby99n	242	119	a	a	DT
cord-027654-k0uby99n	242	120	human	human	JJ
cord-027654-k0uby99n	242	121	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	242	122	ciency	ciency	NNP
cord-027654-k0uby99n	242	123	virus	virus	NN
cord-027654-k0uby99n	242	124	type	type	NN
cord-027654-k0uby99n	242	125	2	2	CD
cord-027654-k0uby99n	242	126	recombinant	recombinant	JJ
cord-027654-k0uby99n	242	127	canarypox	canarypox	NN
cord-027654-k0uby99n	242	128	(	(	-LRB-
cord-027654-k0uby99n	242	129	ALVAC	ALVAC	NNP
cord-027654-k0uby99n	242	130	)	)	-RRB-
cord-027654-k0uby99n	242	131	vaccine	vaccine	NN
cord-027654-k0uby99n	242	132	candidate	candidate	NN
cord-027654-k0uby99n	242	133	in	in	IN
cord-027654-k0uby99n	242	134	cynomolgus	cynomolgus	JJ
cord-027654-k0uby99n	242	135	monkeys	monkey	NNS
cord-027654-k0uby99n	242	136	Mature	Mature	NNP
cord-027654-k0uby99n	242	137	dendritic	dendritic	JJ
cord-027654-k0uby99n	242	138	cells	cell	NNS
cord-027654-k0uby99n	242	139	infected	infect	VBN
cord-027654-k0uby99n	242	140	with	with	IN
cord-027654-k0uby99n	242	141	canarypox	canarypox	NN
cord-027654-k0uby99n	242	142	virus	virus	NN
cord-027654-k0uby99n	242	143	elicit	elicit	VBP
cord-027654-k0uby99n	242	144	strong	strong	JJ
cord-027654-k0uby99n	242	145	anti	anti	JJ
cord-027654-k0uby99n	242	146	-	-	JJ
cord-027654-k0uby99n	242	147	human	human	JJ
cord-027654-k0uby99n	242	148	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	242	149	ciency	ciency	NNP
cord-027654-k0uby99n	242	150	virus	virus	NN
cord-027654-k0uby99n	242	151	CD8	CD8	NNP
cord-027654-k0uby99n	242	152	+	+	CC
cord-027654-k0uby99n	242	153	and	and	CC
cord-027654-k0uby99n	242	154	CD4	CD4	NNP
cord-027654-k0uby99n	242	155	+	+	CC
cord-027654-k0uby99n	242	156	T	t	NN
cord-027654-k0uby99n	242	157	-	-	HYPH
cord-027654-k0uby99n	242	158	cell	cell	NN
cord-027654-k0uby99n	242	159	responses	response	NNS
cord-027654-k0uby99n	242	160	from	from	IN
cord-027654-k0uby99n	242	161	chronically	chronically	RB
cord-027654-k0uby99n	242	162	infected	infect	VBN
cord-027654-k0uby99n	242	163	individuals	individual	NNS
cord-027654-k0uby99n	242	164	Potentiation	Potentiation	NNP
cord-027654-k0uby99n	242	165	of	of	IN
cord-027654-k0uby99n	242	166	simian	simian	JJ
cord-027654-k0uby99n	242	167	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	242	168	ciency	ciency	NNP
cord-027654-k0uby99n	242	169	virus	virus	NN
cord-027654-k0uby99n	242	170	(	(	-LRB-
cord-027654-k0uby99n	242	171	SIV)-specifi	SIV)-specifi	NNP
cord-027654-k0uby99n	242	172	c	c	NN
cord-027654-k0uby99n	242	173	CD4(+	CD4(+	NNP
cord-027654-k0uby99n	242	174	)	)	-RRB-
cord-027654-k0uby99n	242	175	and	and	CC
cord-027654-k0uby99n	242	176	CD8(+	cd8(+	CD
cord-027654-k0uby99n	242	177	)	)	-RRB-
cord-027654-k0uby99n	243	1	T	T	NNP
cord-027654-k0uby99n	243	2	cell	cell	NN
cord-027654-k0uby99n	243	3	responses	response	NNS
cord-027654-k0uby99n	243	4	by	by	IN
cord-027654-k0uby99n	243	5	a	a	DT
cord-027654-k0uby99n	243	6	DNA	DNA	NNP
cord-027654-k0uby99n	243	7	-	-	HYPH
cord-027654-k0uby99n	243	8	SIV	SIV	NNP
cord-027654-k0uby99n	243	9	and	and	CC
cord-027654-k0uby99n	243	10	NYVAC	NYVAC	NNP
cord-027654-k0uby99n	243	11	-	-	HYPH
cord-027654-k0uby99n	243	12	SIV	SIV	NNP
cord-027654-k0uby99n	243	13	prime	prime	NN
cord-027654-k0uby99n	243	14	/	/	SYM
cord-027654-k0uby99n	243	15	boost	boost	NN
cord-027654-k0uby99n	243	16	regimen	regimen	NN
cord-027654-k0uby99n	243	17	Cross	Cross	NNP
cord-027654-k0uby99n	243	18	-	-	HYPH
cord-027654-k0uby99n	243	19	protection	protection	NN
cord-027654-k0uby99n	243	20	against	against	IN
cord-027654-k0uby99n	243	21	mucosal	mucosal	JJ
cord-027654-k0uby99n	243	22	simian	simian	JJ
cord-027654-k0uby99n	243	23	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	243	24	ciency	ciency	NNP
cord-027654-k0uby99n	243	25	virus	virus	NN
cord-027654-k0uby99n	243	26	(	(	-LRB-
cord-027654-k0uby99n	243	27	SIVsm	sivsm	NN
cord-027654-k0uby99n	243	28	)	)	-RRB-
cord-027654-k0uby99n	243	29	challenge	challenge	NN
cord-027654-k0uby99n	243	30	in	in	IN
cord-027654-k0uby99n	243	31	human	human	JJ
cord-027654-k0uby99n	243	32	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	243	33	ciency	ciency	NNP
cord-027654-k0uby99n	243	34	virus	virus	NN
cord-027654-k0uby99n	243	35	type	type	NN
cord-027654-k0uby99n	243	36	2-vaccinated	2-vaccinated	CD
cord-027654-k0uby99n	243	37	cynomolgus	cynomolgus	NNP
cord-027654-k0uby99n	243	38	monkeys	monkey	NNS
cord-027654-k0uby99n	243	39	Induction	Induction	NNP
cord-027654-k0uby99n	243	40	of	of	IN
cord-027654-k0uby99n	243	41	cytotoxic	cytotoxic	JJ
cord-027654-k0uby99n	243	42	T	t	NN
cord-027654-k0uby99n	243	43	lymphocytes	lymphocyte	NNS
cord-027654-k0uby99n	243	44	by	by	IN
cord-027654-k0uby99n	243	45	recombinant	recombinant	JJ
cord-027654-k0uby99n	243	46	canarypox	canarypox	NN
cord-027654-k0uby99n	243	47	(	(	-LRB-
cord-027654-k0uby99n	243	48	ALVAC	ALVAC	NNP
cord-027654-k0uby99n	243	49	)	)	-RRB-
cord-027654-k0uby99n	243	50	and	and	CC
cord-027654-k0uby99n	243	51	attenuated	attenuated	JJ
cord-027654-k0uby99n	243	52	vaccinia	vaccinia	NN
cord-027654-k0uby99n	243	53	(	(	-LRB-
cord-027654-k0uby99n	243	54	NYVAC	NYVAC	NNP
cord-027654-k0uby99n	243	55	)	)	-RRB-
cord-027654-k0uby99n	243	56	viruses	virus	NNS
cord-027654-k0uby99n	243	57	expressing	express	VBG
cord-027654-k0uby99n	243	58	the	the	DT
cord-027654-k0uby99n	243	59	HIV-1	HIV-1	NNP
cord-027654-k0uby99n	243	60	envelope	envelope	NN
cord-027654-k0uby99n	243	61	glycoprotein	glycoprotein	NN
cord-027654-k0uby99n	243	62	Memory	memory	NN
cord-027654-k0uby99n	243	63	cytotoxic	cytotoxic	JJ
cord-027654-k0uby99n	243	64	T	t	NN
cord-027654-k0uby99n	243	65	lymphocyte	lymphocyte	NN
cord-027654-k0uby99n	243	66	responses	response	NNS
cord-027654-k0uby99n	243	67	in	in	IN
cord-027654-k0uby99n	243	68	human	human	JJ
cord-027654-k0uby99n	243	69	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	243	70	ciency	ciency	NNP
cord-027654-k0uby99n	243	71	virus	virus	NN
cord-027654-k0uby99n	243	72	type	type	NN
cord-027654-k0uby99n	243	73	1	1	CD
cord-027654-k0uby99n	244	1	(	(	-LRB-
cord-027654-k0uby99n	244	2	HIV-1)-negative	hiv-1)-negative	JJ
cord-027654-k0uby99n	244	3	volunteers	volunteer	NNS
cord-027654-k0uby99n	244	4	immunized	immunize	VBN
cord-027654-k0uby99n	244	5	with	with	IN
cord-027654-k0uby99n	244	6	a	a	DT
cord-027654-k0uby99n	244	7	recombinant	recombinant	JJ
cord-027654-k0uby99n	244	8	canarypox	canarypox	NN
cord-027654-k0uby99n	244	9	expressing	express	VBG
cord-027654-k0uby99n	244	10	gp	gp	NNP
cord-027654-k0uby99n	244	11	160	160	CD
cord-027654-k0uby99n	244	12	of	of	IN
cord-027654-k0uby99n	244	13	HIV-1	HIV-1	NNP
cord-027654-k0uby99n	244	14	and	and	CC
cord-027654-k0uby99n	244	15	boosted	boost	VBD
cord-027654-k0uby99n	244	16	with	with	IN
cord-027654-k0uby99n	244	17	a	a	DT
cord-027654-k0uby99n	244	18	recombinant	recombinant	JJ
cord-027654-k0uby99n	244	19	gp160	gp160	NNP
cord-027654-k0uby99n	244	20	Clade	Clade	NNP
cord-027654-k0uby99n	244	21	B	B	NNP
cord-027654-k0uby99n	244	22	-	-	HYPH
cord-027654-k0uby99n	244	23	based	base	VBN
cord-027654-k0uby99n	244	24	HIV-1	HIV-1	NNP
cord-027654-k0uby99n	244	25	vaccines	vaccine	NNS
cord-027654-k0uby99n	244	26	elicit	elicit	VBP
cord-027654-k0uby99n	244	27	cross	cross	JJ
cord-027654-k0uby99n	244	28	-	-	JJ
cord-027654-k0uby99n	244	29	clade	clade	JJ
cord-027654-k0uby99n	244	30	cytotoxic	cytotoxic	JJ
cord-027654-k0uby99n	244	31	T	t	NN
cord-027654-k0uby99n	244	32	lymphocyte	lymphocyte	NN
cord-027654-k0uby99n	244	33	reactivities	reactivity	NNS
cord-027654-k0uby99n	244	34	in	in	IN
cord-027654-k0uby99n	244	35	uninfected	uninfected	JJ
cord-027654-k0uby99n	244	36	volunteers	volunteer	NNS
cord-027654-k0uby99n	244	37	Induction	Induction	NNP
cord-027654-k0uby99n	244	38	of	of	IN
cord-027654-k0uby99n	244	39	neutralizing	neutralize	VBG
cord-027654-k0uby99n	244	40	antibodies	antibody	NNS
cord-027654-k0uby99n	244	41	and	and	CC
cord-027654-k0uby99n	244	42	gag	gag	NN
cord-027654-k0uby99n	244	43	-	-	HYPH
cord-027654-k0uby99n	244	44	specifi	specifi	NN
cord-027654-k0uby99n	244	45	c	c	NN
cord-027654-k0uby99n	244	46	cellular	cellular	JJ
cord-027654-k0uby99n	244	47	immune	immune	JJ
cord-027654-k0uby99n	244	48	responses	response	NNS
cord-027654-k0uby99n	244	49	to	to	IN
cord-027654-k0uby99n	244	50	an	an	DT
cord-027654-k0uby99n	244	51	R5	R5	NNP
cord-027654-k0uby99n	244	52	primary	primary	JJ
cord-027654-k0uby99n	244	53	isolate	isolate	NN
cord-027654-k0uby99n	244	54	of	of	IN
cord-027654-k0uby99n	244	55	human	human	JJ
cord-027654-k0uby99n	244	56	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	244	57	ciency	ciency	NNP
cord-027654-k0uby99n	244	58	virus	virus	NN
cord-027654-k0uby99n	244	59	type	type	NN
cord-027654-k0uby99n	244	60	1	1	CD
cord-027654-k0uby99n	244	61	in	in	IN
cord-027654-k0uby99n	244	62	rhesus	rhesu	NNS
cord-027654-k0uby99n	244	63	macaques	macaque	NNS
cord-027654-k0uby99n	244	64	ALVAC	ALVAC	NNP
cord-027654-k0uby99n	244	65	-	-	HYPH
cord-027654-k0uby99n	244	66	SIVgag	SIVgag	NNP
cord-027654-k0uby99n	244	67	-	-	HYPH
cord-027654-k0uby99n	244	68	pol	pol	JJ
cord-027654-k0uby99n	244	69	-	-	HYPH
cord-027654-k0uby99n	244	70	env	env	NN
cord-027654-k0uby99n	244	71	-	-	HYPH
cord-027654-k0uby99n	244	72	based	base	VBN
cord-027654-k0uby99n	244	73	vaccination	vaccination	NN
cord-027654-k0uby99n	244	74	and	and	CC
cord-027654-k0uby99n	244	75	macaque	macaque	NN
cord-027654-k0uby99n	244	76	major	major	JJ
cord-027654-k0uby99n	244	77	histocompatibility	histocompatibility	NN
cord-027654-k0uby99n	244	78	complex	complex	JJ
cord-027654-k0uby99n	244	79	class	class	NN
cord-027654-k0uby99n	245	1	I	-PRON-	PRP
cord-027654-k0uby99n	245	2	(	(	-LRB-
cord-027654-k0uby99n	245	3	A*01	A*01	NNP
cord-027654-k0uby99n	245	4	)	)	-RRB-
cord-027654-k0uby99n	245	5	delay	delay	VB
cord-027654-k0uby99n	245	6	simian	simian	JJ
cord-027654-k0uby99n	245	7	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	245	8	ciency	ciency	NNP
cord-027654-k0uby99n	245	9	virus	virus	NN
cord-027654-k0uby99n	246	1	SIVmacinduced	SIVmacinduced	NNP
cord-027654-k0uby99n	246	2	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	246	3	ciency	ciency	NNP
cord-027654-k0uby99n	246	4	AAV	AAV	NNP
cord-027654-k0uby99n	246	5	vectors	vector	NNS
cord-027654-k0uby99n	246	6	:	:	:
cord-027654-k0uby99n	246	7	is	be	VBZ
cord-027654-k0uby99n	246	8	clinical	clinical	JJ
cord-027654-k0uby99n	246	9	success	success	NN
cord-027654-k0uby99n	246	10	on	on	IN
cord-027654-k0uby99n	246	11	the	the	DT
cord-027654-k0uby99n	246	12	horizon	horizon	NN
cord-027654-k0uby99n	246	13	?	?	.
cord-027654-k0uby99n	247	1	Venezuelan	venezuelan	JJ
cord-027654-k0uby99n	247	2	equine	equine	NN
cord-027654-k0uby99n	247	3	encephalitis	encephalitis	NN
cord-027654-k0uby99n	247	4	virus	virus	NN
cord-027654-k0uby99n	247	5	vectors	vector	NNS
cord-027654-k0uby99n	247	6	expressing	express	VBG
cord-027654-k0uby99n	247	7	HIV-1	HIV-1	NNP
cord-027654-k0uby99n	247	8	proteins	protein	NNS
cord-027654-k0uby99n	247	9	:	:	:
cord-027654-k0uby99n	247	10	vector	vector	NN
cord-027654-k0uby99n	247	11	design	design	NN
cord-027654-k0uby99n	247	12	strategies	strategy	NNS
cord-027654-k0uby99n	247	13	for	for	IN
cord-027654-k0uby99n	247	14	improved	improved	JJ
cord-027654-k0uby99n	247	15	vaccine	vaccine	NN
cord-027654-k0uby99n	247	16	effi	effi	NNP
cord-027654-k0uby99n	247	17	cacy	cacy	NNP
cord-027654-k0uby99n	247	18	Vaccination	Vaccination	NNP
cord-027654-k0uby99n	247	19	of	of	IN
cord-027654-k0uby99n	247	20	macaques	macaque	NNS
cord-027654-k0uby99n	247	21	against	against	IN
cord-027654-k0uby99n	247	22	pathogenic	pathogenic	JJ
cord-027654-k0uby99n	247	23	simian	simian	JJ
cord-027654-k0uby99n	247	24	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	247	25	ciency	ciency	NNP
cord-027654-k0uby99n	247	26	virus	virus	NN
cord-027654-k0uby99n	247	27	with	with	IN
cord-027654-k0uby99n	247	28	Venezuelan	venezuelan	JJ
cord-027654-k0uby99n	247	29	equine	equine	NN
cord-027654-k0uby99n	247	30	encephalitis	encephalitis	NN
cord-027654-k0uby99n	247	31	virus	virus	NN
cord-027654-k0uby99n	247	32	replicon	replicon	NN
cord-027654-k0uby99n	247	33	particles	particle	NNS
cord-027654-k0uby99n	248	1	Sindbis	sindbis	NN
cord-027654-k0uby99n	248	2	virus	virus	NN
cord-027654-k0uby99n	248	3	vectors	vector	NNS
cord-027654-k0uby99n	248	4	for	for	IN
cord-027654-k0uby99n	248	5	expression	expression	NN
cord-027654-k0uby99n	248	6	in	in	IN
cord-027654-k0uby99n	248	7	animal	animal	NN
cord-027654-k0uby99n	248	8	cells	cell	NNS
cord-027654-k0uby99n	248	9	Evaluation	Evaluation	NNP
cord-027654-k0uby99n	248	10	of	of	IN
cord-027654-k0uby99n	248	11	recombinant	recombinant	JJ
cord-027654-k0uby99n	248	12	alphaviruses	alphavirus	NNS
cord-027654-k0uby99n	248	13	as	as	IN
cord-027654-k0uby99n	248	14	vectors	vector	NNS
cord-027654-k0uby99n	248	15	in	in	IN
cord-027654-k0uby99n	248	16	gene	gene	NN
cord-027654-k0uby99n	248	17	therapy	therapy	NN
cord-027654-k0uby99n	248	18	Replication	replication	NN
cord-027654-k0uby99n	248	19	-	-	HYPH
cord-027654-k0uby99n	248	20	defective	defective	JJ
cord-027654-k0uby99n	248	21	viruses	virus	NNS
cord-027654-k0uby99n	248	22	as	as	IN
cord-027654-k0uby99n	248	23	vaccines	vaccine	NNS
cord-027654-k0uby99n	248	24	and	and	CC
cord-027654-k0uby99n	248	25	vaccine	vaccine	NN
cord-027654-k0uby99n	248	26	vectors	vector	NNS
cord-027654-k0uby99n	249	1	An	an	DT
cord-027654-k0uby99n	249	2	effective	effective	JJ
cord-027654-k0uby99n	249	3	AIDS	AIDS	NNP
cord-027654-k0uby99n	249	4	vaccine	vaccine	NN
cord-027654-k0uby99n	249	5	based	base	VBN
cord-027654-k0uby99n	249	6	on	on	IN
cord-027654-k0uby99n	249	7	live	live	JJ
cord-027654-k0uby99n	249	8	attenuated	attenuated	JJ
cord-027654-k0uby99n	249	9	vesicular	vesicular	JJ
cord-027654-k0uby99n	249	10	stomatitis	stomatitis	NN
cord-027654-k0uby99n	249	11	virus	virus	NN
cord-027654-k0uby99n	249	12	recombinants	recombinant	VBZ
cord-027654-k0uby99n	249	13	West	West	NNP
cord-027654-k0uby99n	249	14	Nile	Nile	NNP
cord-027654-k0uby99n	249	15	virus	virus	NN
cord-027654-k0uby99n	249	16	/	/	SYM
cord-027654-k0uby99n	249	17	dengue	dengue	NN
cord-027654-k0uby99n	249	18	type	type	NN
cord-027654-k0uby99n	249	19	4	4	CD
cord-027654-k0uby99n	249	20	virus	virus	NN
cord-027654-k0uby99n	249	21	chimeras	chimera	NNS
cord-027654-k0uby99n	249	22	that	that	WDT
cord-027654-k0uby99n	249	23	are	be	VBP
cord-027654-k0uby99n	249	24	reduced	reduce	VBN
cord-027654-k0uby99n	249	25	in	in	IN
cord-027654-k0uby99n	249	26	neurovirulence	neurovirulence	NN
cord-027654-k0uby99n	249	27	and	and	CC
cord-027654-k0uby99n	249	28	peripheral	peripheral	JJ
cord-027654-k0uby99n	249	29	virulence	virulence	NN
cord-027654-k0uby99n	249	30	without	without	IN
cord-027654-k0uby99n	249	31	loss	loss	NN
cord-027654-k0uby99n	249	32	of	of	IN
cord-027654-k0uby99n	249	33	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	249	34	or	or	CC
cord-027654-k0uby99n	249	35	protective	protective	JJ
cord-027654-k0uby99n	249	36	effi	effi	NNP
cord-027654-k0uby99n	249	37	cacy	cacy	NN
cord-027654-k0uby99n	250	1	Live	live	JJ
cord-027654-k0uby99n	250	2	attenuated	attenuated	JJ
cord-027654-k0uby99n	250	3	recombinant	recombinant	JJ
cord-027654-k0uby99n	250	4	vaccine	vaccine	NN
cord-027654-k0uby99n	250	5	protects	protect	VBZ
cord-027654-k0uby99n	250	6	nonhuman	nonhuman	NN
cord-027654-k0uby99n	250	7	primates	primate	NNS
cord-027654-k0uby99n	250	8	against	against	IN
cord-027654-k0uby99n	250	9	Ebola	Ebola	NNP
cord-027654-k0uby99n	250	10	and	and	CC
cord-027654-k0uby99n	250	11	Marburg	Marburg	NNP
cord-027654-k0uby99n	250	12	viruses	virus	NNS
cord-027654-k0uby99n	251	1	Priming	prime	VBG
cord-027654-k0uby99n	251	2	with	with	IN
cord-027654-k0uby99n	251	3	plasmid	plasmid	NN
cord-027654-k0uby99n	252	1	DNAs	dna	NNS
cord-027654-k0uby99n	252	2	expressing	express	VBG
cord-027654-k0uby99n	252	3	interleukin-12	interleukin-12	NNP
cord-027654-k0uby99n	252	4	and	and	CC
cord-027654-k0uby99n	252	5	simian	simian	JJ
cord-027654-k0uby99n	252	6	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	252	7	ciency	ciency	NNP
cord-027654-k0uby99n	252	8	virus	virus	NN
cord-027654-k0uby99n	252	9	gag	gag	NN
cord-027654-k0uby99n	252	10	enhances	enhance	VBZ
cord-027654-k0uby99n	252	11	the	the	DT
cord-027654-k0uby99n	252	12	immunogenicity	immunogenicity	NN
cord-027654-k0uby99n	252	13	and	and	CC
cord-027654-k0uby99n	252	14	effi	effi	NNP
cord-027654-k0uby99n	252	15	cacy	cacy	NNP
cord-027654-k0uby99n	252	16	of	of	IN
cord-027654-k0uby99n	252	17	an	an	DT
cord-027654-k0uby99n	252	18	experimental	experimental	JJ
cord-027654-k0uby99n	252	19	AIDS	AIDS	NNP
cord-027654-k0uby99n	252	20	vaccine	vaccine	NN
cord-027654-k0uby99n	252	21	based	base	VBN
cord-027654-k0uby99n	252	22	on	on	IN
cord-027654-k0uby99n	252	23	recombinant	recombinant	JJ
cord-027654-k0uby99n	252	24	vesicular	vesicular	JJ
cord-027654-k0uby99n	252	25	stomatitis	stomatitis	NN
cord-027654-k0uby99n	252	26	virus	virus	NN
cord-027654-k0uby99n	253	1	A	a	DT
cord-027654-k0uby99n	253	2	single	single	JJ
cord-027654-k0uby99n	253	3	-	-	HYPH
cord-027654-k0uby99n	253	4	cycle	cycle	NN
cord-027654-k0uby99n	253	5	vaccine	vaccine	NN
cord-027654-k0uby99n	253	6	vector	vector	NN
cord-027654-k0uby99n	253	7	based	base	VBN
cord-027654-k0uby99n	253	8	on	on	IN
cord-027654-k0uby99n	253	9	vesicular	vesicular	JJ
cord-027654-k0uby99n	253	10	stomatitis	stomatitis	NN
cord-027654-k0uby99n	253	11	virus	virus	NN
cord-027654-k0uby99n	253	12	can	can	MD
cord-027654-k0uby99n	253	13	induce	induce	VB
cord-027654-k0uby99n	253	14	immune	immune	JJ
cord-027654-k0uby99n	253	15	responses	response	NNS
cord-027654-k0uby99n	253	16	comparable	comparable	JJ
cord-027654-k0uby99n	253	17	to	to	IN
cord-027654-k0uby99n	253	18	those	those	DT
cord-027654-k0uby99n	253	19	generated	generate	VBN
cord-027654-k0uby99n	253	20	by	by	IN
cord-027654-k0uby99n	253	21	a	a	DT
cord-027654-k0uby99n	253	22	replication	replication	NN
cord-027654-k0uby99n	253	23	-	-	HYPH
cord-027654-k0uby99n	253	24	competent	competent	JJ
cord-027654-k0uby99n	253	25	vector	vector	NN
cord-027654-k0uby99n	254	1	A	a	DT
cord-027654-k0uby99n	254	2	live	live	JJ
cord-027654-k0uby99n	254	3	,	,	,
cord-027654-k0uby99n	254	4	attenuated	attenuated	JJ
cord-027654-k0uby99n	254	5	recombinant	recombinant	JJ
cord-027654-k0uby99n	254	6	West	West	NNP
cord-027654-k0uby99n	254	7	Nile	Nile	NNP
cord-027654-k0uby99n	254	8	virus	virus	NN
cord-027654-k0uby99n	254	9	vaccine	vaccine	NN
cord-027654-k0uby99n	255	1	A	a	DT
cord-027654-k0uby99n	255	2	single	single	JJ
cord-027654-k0uby99n	255	3	intranasal	intranasal	NN
cord-027654-k0uby99n	255	4	inoculation	inoculation	NN
cord-027654-k0uby99n	255	5	with	with	IN
cord-027654-k0uby99n	255	6	a	a	DT
cord-027654-k0uby99n	255	7	paramyxovirusvectored	paramyxovirusvectored	JJ
cord-027654-k0uby99n	255	8	vaccine	vaccine	NN
cord-027654-k0uby99n	255	9	protects	protect	VBZ
cord-027654-k0uby99n	255	10	guinea	guinea	NN
cord-027654-k0uby99n	255	11	pigs	pig	NNS
cord-027654-k0uby99n	255	12	against	against	IN
cord-027654-k0uby99n	255	13	a	a	DT
cord-027654-k0uby99n	255	14	lethal	lethal	JJ
cord-027654-k0uby99n	255	15	-	-	HYPH
cord-027654-k0uby99n	255	16	dose	dose	NN
cord-027654-k0uby99n	255	17	Ebola	Ebola	NNP
cord-027654-k0uby99n	255	18	virus	virus	NN
cord-027654-k0uby99n	255	19	challenge	challenge	VBP
cord-027654-k0uby99n	255	20	Vaccine	vaccine	NN
cord-027654-k0uby99n	255	21	cell	cell	NN
cord-027654-k0uby99n	255	22	substrates	substrate	NNS
cord-027654-k0uby99n	255	23	Cell	Cell	NNP
cord-027654-k0uby99n	255	24	line	line	NN
cord-027654-k0uby99n	255	25	issues	issue	NNS
cord-027654-k0uby99n	255	26	:	:	:
cord-027654-k0uby99n	255	27	historical	historical	JJ
cord-027654-k0uby99n	255	28	and	and	CC
cord-027654-k0uby99n	255	29	future	future	JJ
cord-027654-k0uby99n	255	30	perspectives	perspective	NNS
cord-027654-k0uby99n	255	31	Points	point	NNS
cord-027654-k0uby99n	255	32	to	to	TO
cord-027654-k0uby99n	255	33	Consider	consider	VB
cord-027654-k0uby99n	255	34	in	in	IN
cord-027654-k0uby99n	255	35	the	the	DT
cord-027654-k0uby99n	255	36	Characterization	characterization	NN
cord-027654-k0uby99n	255	37	of	of	IN
cord-027654-k0uby99n	255	38	Cell	Cell	NNP
cord-027654-k0uby99n	255	39	Lines	line	NNS
cord-027654-k0uby99n	255	40	Used	use	VBN
cord-027654-k0uby99n	255	41	to	to	TO
cord-027654-k0uby99n	255	42	Produce	produce	VB
cord-027654-k0uby99n	255	43	Biologicals	biological	NNS
cord-027654-k0uby99n	255	44	.	.	.
cord-027654-k0uby99n	256	1	United	United	NNP
cord-027654-k0uby99n	256	2	States	States	NNP
cord-027654-k0uby99n	256	3	Food	Food	NNP
cord-027654-k0uby99n	256	4	and	and	CC
cord-027654-k0uby99n	256	5	Drug	Drug	NNP
cord-027654-k0uby99n	256	6	Administration	Administration	NNP
cord-027654-k0uby99n	256	7	,	,	,
cord-027654-k0uby99n	256	8	Department	Department	NNP
cord-027654-k0uby99n	256	9	of	of	IN
cord-027654-k0uby99n	256	10	Health	Health	NNP
cord-027654-k0uby99n	256	11	and	and	CC
cord-027654-k0uby99n	256	12	Human	Human	NNP
cord-027654-k0uby99n	256	13	Services	Services	NNPS
cord-027654-k0uby99n	256	14	Use	Use	NNP
cord-027654-k0uby99n	256	15	of	of	IN
cord-027654-k0uby99n	256	16	live	live	JJ
cord-027654-k0uby99n	256	17	bacterial	bacterial	JJ
cord-027654-k0uby99n	256	18	vaccine	vaccine	NN
cord-027654-k0uby99n	256	19	vectors	vector	NNS
cord-027654-k0uby99n	256	20	for	for	IN
cord-027654-k0uby99n	256	21	antigen	antigen	NN
cord-027654-k0uby99n	256	22	delivery	delivery	NN
cord-027654-k0uby99n	256	23	:	:	:
cord-027654-k0uby99n	256	24	potential	potential	NN
cord-027654-k0uby99n	256	25	and	and	CC
cord-027654-k0uby99n	256	26	limitations	limitation	NNS
cord-027654-k0uby99n	256	27	Progress	progress	VB
cord-027654-k0uby99n	256	28	towards	towards	IN
cord-027654-k0uby99n	256	29	the	the	DT
cord-027654-k0uby99n	256	30	use	use	NN
cord-027654-k0uby99n	256	31	of	of	IN
cord-027654-k0uby99n	256	32	Listeria	Listeria	NNP
cord-027654-k0uby99n	256	33	monocytogenes	monocytogenes	NNP
cord-027654-k0uby99n	256	34	as	as	IN
cord-027654-k0uby99n	256	35	a	a	DT
cord-027654-k0uby99n	256	36	live	live	JJ
cord-027654-k0uby99n	256	37	bacterial	bacterial	JJ
cord-027654-k0uby99n	256	38	vaccine	vaccine	NN
cord-027654-k0uby99n	256	39	vector	vector	NN
cord-027654-k0uby99n	256	40	for	for	IN
cord-027654-k0uby99n	256	41	the	the	DT
cord-027654-k0uby99n	256	42	delivery	delivery	NN
cord-027654-k0uby99n	256	43	of	of	IN
cord-027654-k0uby99n	256	44	HIV	HIV	NNP
cord-027654-k0uby99n	256	45	antigens	antigen	NNS
cord-027654-k0uby99n	256	46	Novel	Novel	NNP
cord-027654-k0uby99n	256	47	bacterial	bacterial	JJ
cord-027654-k0uby99n	256	48	systems	system	NNS
cord-027654-k0uby99n	256	49	for	for	IN
cord-027654-k0uby99n	256	50	the	the	DT
cord-027654-k0uby99n	256	51	delivery	delivery	NN
cord-027654-k0uby99n	256	52	of	of	IN
cord-027654-k0uby99n	256	53	recombinant	recombinant	JJ
cord-027654-k0uby99n	256	54	protein	protein	NN
cord-027654-k0uby99n	256	55	or	or	CC
cord-027654-k0uby99n	256	56	DNA	DNA	NNP
cord-027654-k0uby99n	256	57	Phagolysosome	Phagolysosome	NNP
cord-027654-k0uby99n	256	58	formation	formation	NN
cord-027654-k0uby99n	256	59	,	,	,
cord-027654-k0uby99n	256	60	cyclic	cyclic	JJ
cord-027654-k0uby99n	256	61	adenosine	adenosine	NN
cord-027654-k0uby99n	256	62	3′:5′-monophosphate	3′:5′-monophosphate	NN
cord-027654-k0uby99n	256	63	and	and	CC
cord-027654-k0uby99n	256	64	the	the	DT
cord-027654-k0uby99n	256	65	fate	fate	NN
cord-027654-k0uby99n	256	66	of	of	IN
cord-027654-k0uby99n	256	67	Salmonella	Salmonella	NNP
cord-027654-k0uby99n	256	68	typhimurium	typhimurium	NN
cord-027654-k0uby99n	256	69	within	within	IN
cord-027654-k0uby99n	256	70	mouse	mouse	NN
cord-027654-k0uby99n	256	71	peritoneal	peritoneal	NN
cord-027654-k0uby99n	256	72	macrophages	macrophage	NNS
cord-027654-k0uby99n	256	73	Bacterial	bacterial	JJ
cord-027654-k0uby99n	256	74	vaccine	vaccine	NN
cord-027654-k0uby99n	256	75	vectors	vector	NNS
cord-027654-k0uby99n	256	76	and	and	CC
cord-027654-k0uby99n	256	77	bacillus	bacillus	NN
cord-027654-k0uby99n	256	78	Calmette	Calmette	NNP
cord-027654-k0uby99n	256	79	-	-	HYPH
cord-027654-k0uby99n	256	80	Guerin	Guerin	NNP
cord-027654-k0uby99n	256	81	Protective	protective	JJ
cord-027654-k0uby99n	256	82	immune	immune	JJ
cord-027654-k0uby99n	256	83	responses	response	NNS
cord-027654-k0uby99n	256	84	induced	induce	VBN
cord-027654-k0uby99n	256	85	by	by	IN
cord-027654-k0uby99n	256	86	secretion	secretion	NN
cord-027654-k0uby99n	256	87	of	of	IN
cord-027654-k0uby99n	256	88	a	a	DT
cord-027654-k0uby99n	256	89	chimeric	chimeric	JJ
cord-027654-k0uby99n	256	90	soluble	soluble	JJ
cord-027654-k0uby99n	256	91	protein	protein	NN
cord-027654-k0uby99n	256	92	from	from	IN
cord-027654-k0uby99n	256	93	a	a	DT
cord-027654-k0uby99n	256	94	recombinant	recombinant	JJ
cord-027654-k0uby99n	256	95	Mycobacterium	Mycobacterium	NNP
cord-027654-k0uby99n	256	96	bovis	bovis	NN
cord-027654-k0uby99n	256	97	bacillus	bacillus	NN
cord-027654-k0uby99n	256	98	Calmette	Calmette	NNP
cord-027654-k0uby99n	256	99	-	-	HYPH
cord-027654-k0uby99n	256	100	Guerin	Guerin	NNP
cord-027654-k0uby99n	256	101	vector	vector	NN
cord-027654-k0uby99n	256	102	candidate	candidate	NN
cord-027654-k0uby99n	256	103	vaccine	vaccine	NN
cord-027654-k0uby99n	256	104	for	for	IN
cord-027654-k0uby99n	256	105	human	human	JJ
cord-027654-k0uby99n	256	106	immunodefi	immunodefi	NNP
cord-027654-k0uby99n	256	107	ciency	ciency	NNP
cord-027654-k0uby99n	256	108	virus	virus	NN
cord-027654-k0uby99n	256	109	type	type	NN
cord-027654-k0uby99n	256	110	1	1	CD
cord-027654-k0uby99n	256	111	in	in	IN
cord-027654-k0uby99n	256	112	small	small	JJ
cord-027654-k0uby99n	256	113	animals	animal	NNS
cord-027654-k0uby99n	256	114	Attenuated	attenuate	VBD
cord-027654-k0uby99n	256	115	Shigella	Shigella	NNP
cord-027654-k0uby99n	256	116	as	as	IN
cord-027654-k0uby99n	256	117	a	a	DT
cord-027654-k0uby99n	256	118	DNA	dna	NN
cord-027654-k0uby99n	256	119	delivery	delivery	NN
cord-027654-k0uby99n	256	120	vehicle	vehicle	NN
cord-027654-k0uby99n	256	121	for	for	IN
cord-027654-k0uby99n	256	122	DNA	dna	NN
cord-027654-k0uby99n	256	123	-	-	HYPH
cord-027654-k0uby99n	256	124	mediated	mediate	VBN
cord-027654-k0uby99n	256	125	immunization	immunization	NN
cord-027654-k0uby99n	256	126	Delivery	delivery	NN
cord-027654-k0uby99n	256	127	of	of	IN
cord-027654-k0uby99n	256	128	antigen	antigen	NN
cord-027654-k0uby99n	256	129	-	-	HYPH
cord-027654-k0uby99n	256	130	encoding	encode	VBG
cord-027654-k0uby99n	256	131	plasmid	plasmid	NN
cord-027654-k0uby99n	256	132	DNA	dna	NN
cord-027654-k0uby99n	256	133	into	into	IN
cord-027654-k0uby99n	256	134	the	the	DT
cord-027654-k0uby99n	256	135	cytosol	cytosol	NN
cord-027654-k0uby99n	256	136	of	of	IN
cord-027654-k0uby99n	256	137	macrophages	macrophage	NNS
cord-027654-k0uby99n	256	138	by	by	IN
cord-027654-k0uby99n	256	139	attenuated	attenuated	JJ
cord-027654-k0uby99n	256	140	suicide	suicide	NN
cord-027654-k0uby99n	256	141	Listeria	Listeria	NNP
cord-027654-k0uby99n	256	142	monocytogenes	monocytogene	VBZ
cord-027654-k0uby99n	256	143	Oral	oral	JJ
cord-027654-k0uby99n	256	144	somatic	somatic	JJ
cord-027654-k0uby99n	256	145	transgene	transgene	NN
cord-027654-k0uby99n	256	146	vaccination	vaccination	NN
cord-027654-k0uby99n	256	147	using	use	VBG
cord-027654-k0uby99n	256	148	attenuated	attenuate	VBN
cord-027654-k0uby99n	256	149	S.	S.	NNP
cord-027654-k0uby99n	256	150	typhimurium	typhimurium	NNP
cord-027654-k0uby99n	256	151	Gene	Gene	NNP
cord-027654-k0uby99n	256	152	transfer	transfer	NN
cord-027654-k0uby99n	256	153	in	in	IN
cord-027654-k0uby99n	256	154	dendritic	dendritic	JJ
cord-027654-k0uby99n	256	155	cells	cell	NNS
cord-027654-k0uby99n	256	156	,	,	,
cord-027654-k0uby99n	256	157	induced	induce	VBN
cord-027654-k0uby99n	256	158	by	by	IN
cord-027654-k0uby99n	256	159	oral	oral	JJ
cord-027654-k0uby99n	256	160	DNA	dna	NN
cord-027654-k0uby99n	256	161	vaccination	vaccination	NN
cord-027654-k0uby99n	256	162	with	with	IN
cord-027654-k0uby99n	256	163	Salmonella	Salmonella	NNP
cord-027654-k0uby99n	256	164	typhimurium	typhimurium	NN
cord-027654-k0uby99n	256	165	,	,	,
cord-027654-k0uby99n	256	166	results	result	NNS
cord-027654-k0uby99n	256	167	in	in	IN
cord-027654-k0uby99n	256	168	protective	protective	JJ
cord-027654-k0uby99n	256	169	immunity	immunity	NN
cord-027654-k0uby99n	256	170	against	against	IN
cord-027654-k0uby99n	256	171	a	a	DT
cord-027654-k0uby99n	256	172	murine	murine	JJ
cord-027654-k0uby99n	256	173	fi	fi	FW
cord-027654-k0uby99n	256	174	brosarcoma	brosarcoma	FW
cord-027654-k0uby99n	256	175	Wild	wild	JJ
cord-027654-k0uby99n	256	176	-	-	HYPH
cord-027654-k0uby99n	256	177	type	type	NN
cord-027654-k0uby99n	256	178	HFE	HFE	NNP
cord-027654-k0uby99n	256	179	protein	protein	NN
cord-027654-k0uby99n	256	180	normalizes	normalize	VBZ
cord-027654-k0uby99n	256	181	transferrin	transferrin	NN
cord-027654-k0uby99n	256	182	iron	iron	NN
cord-027654-k0uby99n	256	183	accumulation	accumulation	NN
cord-027654-k0uby99n	256	184	in	in	IN
cord-027654-k0uby99n	256	185	macrophages	macrophage	NNS
cord-027654-k0uby99n	256	186	from	from	IN
cord-027654-k0uby99n	256	187	subjects	subject	NNS
cord-027654-k0uby99n	256	188	with	with	IN
cord-027654-k0uby99n	256	189	hereditary	hereditary	JJ
cord-027654-k0uby99n	256	190	hemochromatosis	hemochromatosis	NN
cord-027654-k0uby99n	257	1	A	a	DT
cord-027654-k0uby99n	257	2	multiclade	multiclade	JJ
cord-027654-k0uby99n	257	3	HIV-1	HIV-1	NNP
cord-027654-k0uby99n	257	4	DNA	DNA	NNP
cord-027654-k0uby99n	257	5	vaccine	vaccine	NN
cord-027654-k0uby99n	257	6	elicits	elicit	VBZ
cord-027654-k0uby99n	257	7	humoral	humoral	JJ
cord-027654-k0uby99n	257	8	and	and	CC
cord-027654-k0uby99n	257	9	sustained	sustained	JJ
cord-027654-k0uby99n	257	10	cellular	cellular	JJ
cord-027654-k0uby99n	257	11	immune	immune	JJ
cord-027654-k0uby99n	257	12	responses	response	NNS
cord-027654-k0uby99n	257	13	in	in	IN
cord-027654-k0uby99n	257	14	humans	human	NNS
cord-027654-k0uby99n	257	15	in	in	IN
cord-027654-k0uby99n	257	16	a	a	DT
cord-027654-k0uby99n	257	17	randomized	randomized	JJ
cord-027654-k0uby99n	257	18	Phase	phase	NN
cord-027654-k0uby99n	258	1	I	-PRON-	PRP
cord-027654-k0uby99n	258	2	clinical	clinical	JJ
cord-027654-k0uby99n	258	3	trial	trial	NN
cord-027654-k0uby99n	259	1	A	a	DT
cord-027654-k0uby99n	259	2	DNA	dna	NN
cord-027654-k0uby99n	259	3	vaccine	vaccine	NN
cord-027654-k0uby99n	259	4	for	for	IN
cord-027654-k0uby99n	259	5	Ebola	Ebola	NNP
cord-027654-k0uby99n	259	6	virus	virus	NN
cord-027654-k0uby99n	259	7	is	be	VBZ
cord-027654-k0uby99n	259	8	safe	safe	JJ
cord-027654-k0uby99n	259	9	and	and	CC
cord-027654-k0uby99n	259	10	immunogenic	immunogenic	JJ
cord-027654-k0uby99n	259	11	in	in	IN
cord-027654-k0uby99n	259	12	a	a	DT
cord-027654-k0uby99n	259	13	phase	phase	NN
cord-027654-k0uby99n	259	14	I	-PRON-	PRP
cord-027654-k0uby99n	259	15	clinical	clinical	JJ
cord-027654-k0uby99n	259	16	trial	trial	NN
cord-027654-k0uby99n	260	1	A	a	DT
cord-027654-k0uby99n	260	2	West	West	NNP
cord-027654-k0uby99n	260	3	Nile	Nile	NNP
cord-027654-k0uby99n	260	4	Virus	Virus	NNP
cord-027654-k0uby99n	260	5	vaccine	vaccine	NN
cord-027654-k0uby99n	260	6	induces	induce	VBZ
cord-027654-k0uby99n	260	7	neutralieing	neutraliee	VBG
cord-027654-k0uby99n	260	8	antibody	antibody	NN
cord-027654-k0uby99n	260	9	in	in	IN
cord-027654-k0uby99n	260	10	healthy	healthy	JJ
cord-027654-k0uby99n	260	11	adults	adult	NNS
cord-027654-k0uby99n	260	12	in	in	IN
cord-027654-k0uby99n	260	13	a	a	DT
cord-027654-k0uby99n	260	14	phase	phase	NN
cord-027654-k0uby99n	260	15	I	-PRON-	PRP
cord-027654-k0uby99n	260	16	clinical	clinical	JJ
cord-027654-k0uby99n	260	17	trial	trial	NN
cord-027654-k0uby99n	260	18	West	West	NNP
cord-027654-k0uby99n	260	19	Nile	Nile	NNP
cord-027654-k0uby99n	260	20	Virus	Virus	NNP
cord-027654-k0uby99n	260	21	recombinant	recombinant	JJ
cord-027654-k0uby99n	260	22	DNA	dna	NN
cord-027654-k0uby99n	260	23	vaccine	vaccine	NN
cord-027654-k0uby99n	260	24	protects	protect	VBZ
cord-027654-k0uby99n	260	25	mouse	mouse	NN
cord-027654-k0uby99n	260	26	and	and	CC
cord-027654-k0uby99n	260	27	horse	horse	NN
cord-027654-k0uby99n	260	28	from	from	IN
cord-027654-k0uby99n	260	29	virus	virus	NN
cord-027654-k0uby99n	260	30	challenge	challenge	NN
cord-027654-k0uby99n	260	31	and	and	CC
cord-027654-k0uby99n	260	32	expresses	express	VBZ
cord-027654-k0uby99n	260	33	in	in	IN
cord-027654-k0uby99n	260	34	vitro	vitro	FW
cord-027654-k0uby99n	260	35	a	a	DT
cord-027654-k0uby99n	260	36	noninfectious	noninfectious	JJ
cord-027654-k0uby99n	260	37	recombinant	recombinant	JJ
cord-027654-k0uby99n	260	38	antigen	antigen	NN
cord-027654-k0uby99n	260	39	that	that	WDT
cord-027654-k0uby99n	260	40	can	can	MD
cord-027654-k0uby99n	260	41	be	be	VB
cord-027654-k0uby99n	260	42	used	use	VBN
cord-027654-k0uby99n	260	43	in	in	IN
cord-027654-k0uby99n	260	44	enzyme	enzyme	NN
cord-027654-k0uby99n	260	45	-	-	HYPH
cord-027654-k0uby99n	260	46	linked	link	VBN
cord-027654-k0uby99n	260	47	immunosorbent	immunosorbent	JJ
cord-027654-k0uby99n	260	48	assays	assay	NNS
cord-027654-k0uby99n	260	49	DNA	dna	NN
cord-027654-k0uby99n	260	50	vaccines	vaccine	NNS
cord-027654-k0uby99n	260	51	for	for	IN
cord-027654-k0uby99n	260	52	aquacultured	aquacultured	JJ
cord-027654-k0uby99n	260	53	fi	fi	NN
cord-027654-k0uby99n	260	54	sh	sh	NNP
cord-027654-k0uby99n	260	55	Prospects	prospect	NNS
cord-027654-k0uby99n	260	56	for	for	IN
cord-027654-k0uby99n	260	57	development	development	NN
cord-027654-k0uby99n	260	58	of	of	IN
cord-027654-k0uby99n	260	59	a	a	DT
cord-027654-k0uby99n	260	60	vaccine	vaccine	NN
cord-027654-k0uby99n	260	61	against	against	IN
cord-027654-k0uby99n	260	62	the	the	DT
cord-027654-k0uby99n	260	63	West	West	NNP
cord-027654-k0uby99n	260	64	Nile	Nile	NNP
cord-027654-k0uby99n	260	65	virus	virus	NN
cord-027654-k0uby99n	260	66	Poxviruses	Poxviruses	NNPS
cord-027654-k0uby99n	260	67	as	as	IN
cord-027654-k0uby99n	260	68	immunization	immunization	NN
cord-027654-k0uby99n	260	69	vehicles	vehicle	NNS