id sid tid token lemma pos cord-018437-yjvwa1ot 1 1 key key JJ cord-018437-yjvwa1ot 2 1 : : : cord-018437-yjvwa1ot 2 2 cord-018437-yjvwa1ot cord-018437-yjvwa1ot NFP cord-018437-yjvwa1ot 2 3 authors author NNS cord-018437-yjvwa1ot 2 4 : : : cord-018437-yjvwa1ot 2 5 Mitchell Mitchell NNP cord-018437-yjvwa1ot 2 6 , , , cord-018437-yjvwa1ot 2 7 Michael Michael NNP cord-018437-yjvwa1ot 2 8 title title NN cord-018437-yjvwa1ot 2 9 : : : cord-018437-yjvwa1ot 2 10 Taxonomy Taxonomy NNP cord-018437-yjvwa1ot 2 11 date date NN cord-018437-yjvwa1ot 2 12 : : : cord-018437-yjvwa1ot 2 13 2013 2013 CD cord-018437-yjvwa1ot 2 14 - - SYM cord-018437-yjvwa1ot 2 15 08 08 CD cord-018437-yjvwa1ot 2 16 - - SYM cord-018437-yjvwa1ot 2 17 26 26 CD cord-018437-yjvwa1ot 2 18 journal journal NN cord-018437-yjvwa1ot 2 19 : : : cord-018437-yjvwa1ot 2 20 Viruses virus NNS cord-018437-yjvwa1ot 2 21 and and CC cord-018437-yjvwa1ot 2 22 the the DT cord-018437-yjvwa1ot 2 23 Lung Lung NNP cord-018437-yjvwa1ot 2 24 DOI DOI NNP cord-018437-yjvwa1ot 2 25 : : : cord-018437-yjvwa1ot 2 26 10.1007/978 10.1007/978 CD cord-018437-yjvwa1ot 2 27 - - HYPH cord-018437-yjvwa1ot 2 28 3 3 CD cord-018437-yjvwa1ot 2 29 - - HYPH cord-018437-yjvwa1ot 2 30 642 642 CD cord-018437-yjvwa1ot 2 31 - - HYPH cord-018437-yjvwa1ot 2 32 40605 40605 CD cord-018437-yjvwa1ot 2 33 - - SYM cord-018437-yjvwa1ot 2 34 8_3 8_3 CD cord-018437-yjvwa1ot 2 35 sha sha NNP cord-018437-yjvwa1ot 2 36 : : : cord-018437-yjvwa1ot 2 37 2076e388465152607e9c3f0c120a48770cd7bd53 2076e388465152607e9c3f0c120a48770cd7bd53 CD cord-018437-yjvwa1ot 2 38 doc_id doc_id CD cord-018437-yjvwa1ot 2 39 : : : cord-018437-yjvwa1ot 2 40 18437 18437 CD cord-018437-yjvwa1ot 3 1 cord_uid cord_uid NN cord-018437-yjvwa1ot 3 2 : : : cord-018437-yjvwa1ot 4 1 yjvwa1ot yjvwa1ot NNS cord-018437-yjvwa1ot 5 1 This this DT cord-018437-yjvwa1ot 5 2 chapter chapter NN cord-018437-yjvwa1ot 5 3 addresses address VBZ cord-018437-yjvwa1ot 5 4 the the DT cord-018437-yjvwa1ot 5 5 classification classification NN cord-018437-yjvwa1ot 5 6 and and CC cord-018437-yjvwa1ot 5 7 taxonomy taxonomy NN cord-018437-yjvwa1ot 5 8 of of IN cord-018437-yjvwa1ot 5 9 viruses virus NNS cord-018437-yjvwa1ot 5 10 with with IN cord-018437-yjvwa1ot 5 11 special special JJ cord-018437-yjvwa1ot 5 12 attention attention NN cord-018437-yjvwa1ot 5 13 to to IN cord-018437-yjvwa1ot 5 14 viruses virus NNS cord-018437-yjvwa1ot 5 15 that that WDT cord-018437-yjvwa1ot 5 16 show show VBP cord-018437-yjvwa1ot 5 17 pneumotropic pneumotropic JJ cord-018437-yjvwa1ot 5 18 properties property NNS cord-018437-yjvwa1ot 5 19 . . . cord-018437-yjvwa1ot 6 1 Information information NN cord-018437-yjvwa1ot 6 2 provided provide VBN cord-018437-yjvwa1ot 6 3 in in IN cord-018437-yjvwa1ot 6 4 this this DT cord-018437-yjvwa1ot 6 5 chapter chapter NN cord-018437-yjvwa1ot 6 6 supplements supplement NNS cord-018437-yjvwa1ot 6 7 that that WDT cord-018437-yjvwa1ot 6 8 provided provide VBD cord-018437-yjvwa1ot 6 9 in in IN cord-018437-yjvwa1ot 6 10 other other JJ cord-018437-yjvwa1ot 6 11 chapters chapter NNS cord-018437-yjvwa1ot 6 12 in in IN cord-018437-yjvwa1ot 6 13 Parts Parts NNP cord-018437-yjvwa1ot 6 14 II II NNP cord-018437-yjvwa1ot 6 15 – – : cord-018437-yjvwa1ot 6 16 V v NN cord-018437-yjvwa1ot 6 17 of of IN cord-018437-yjvwa1ot 6 18 this this DT cord-018437-yjvwa1ot 6 19 volume volume NN cord-018437-yjvwa1ot 6 20 that that WDT cord-018437-yjvwa1ot 6 21 discuss discuss VBP cord-018437-yjvwa1ot 6 22 individual individual JJ cord-018437-yjvwa1ot 6 23 viral viral JJ cord-018437-yjvwa1ot 6 24 pathogens pathogen NNS cord-018437-yjvwa1ot 6 25 . . . cord-018437-yjvwa1ot 7 1 Taxonomy taxonomy NN cord-018437-yjvwa1ot 7 2 may may MD cord-018437-yjvwa1ot 7 3 be be VB cord-018437-yjvwa1ot 7 4 defi defi NNP cord-018437-yjvwa1ot 7 5 ned ned NNP cord-018437-yjvwa1ot 7 6 as as IN cord-018437-yjvwa1ot 7 7 a a DT cord-018437-yjvwa1ot 7 8 logical logical JJ cord-018437-yjvwa1ot 7 9 discipline discipline NN cord-018437-yjvwa1ot 7 10 for for IN cord-018437-yjvwa1ot 7 11 the the DT cord-018437-yjvwa1ot 7 12 identifi identifi NNP cord-018437-yjvwa1ot 7 13 cation cation NNP cord-018437-yjvwa1ot 7 14 and and CC cord-018437-yjvwa1ot 7 15 classifi classifi NNP cord-018437-yjvwa1ot 7 16 cation cation NN cord-018437-yjvwa1ot 7 17 of of IN cord-018437-yjvwa1ot 7 18 biological biological JJ cord-018437-yjvwa1ot 7 19 entities entity NNS cord-018437-yjvwa1ot 7 20 based base VBN cord-018437-yjvwa1ot 7 21 on on IN cord-018437-yjvwa1ot 7 22 objective objective JJ cord-018437-yjvwa1ot 7 23 , , , cord-018437-yjvwa1ot 7 24 measurable measurable JJ cord-018437-yjvwa1ot 7 25 characteristics characteristic NNS cord-018437-yjvwa1ot 7 26 of of IN cord-018437-yjvwa1ot 7 27 relevant relevant JJ cord-018437-yjvwa1ot 7 28 entities entity NNS cord-018437-yjvwa1ot 7 29 . . . cord-018437-yjvwa1ot 8 1 Useful useful JJ cord-018437-yjvwa1ot 8 2 taxonomic taxonomic JJ cord-018437-yjvwa1ot 8 3 systems system NNS cord-018437-yjvwa1ot 8 4 should should MD cord-018437-yjvwa1ot 8 5 be be VB cord-018437-yjvwa1ot 8 6 broadly broadly RB cord-018437-yjvwa1ot 8 7 applicable applicable JJ cord-018437-yjvwa1ot 8 8 across across IN cord-018437-yjvwa1ot 8 9 diverse diverse JJ cord-018437-yjvwa1ot 8 10 types type NNS cord-018437-yjvwa1ot 8 11 of of IN cord-018437-yjvwa1ot 8 12 biological biological JJ cord-018437-yjvwa1ot 8 13 groups group NNS cord-018437-yjvwa1ot 8 14 . . . cord-018437-yjvwa1ot 9 1 They -PRON- PRP cord-018437-yjvwa1ot 9 2 should should MD cord-018437-yjvwa1ot 9 3 also also RB cord-018437-yjvwa1ot 9 4 be be VB cord-018437-yjvwa1ot 9 5 fl fl NNP cord-018437-yjvwa1ot 9 6 exible exible NN cord-018437-yjvwa1ot 9 7 , , , cord-018437-yjvwa1ot 9 8 so so IN cord-018437-yjvwa1ot 9 9 that that IN cord-018437-yjvwa1ot 9 10 new new JJ cord-018437-yjvwa1ot 9 11 data datum NNS cord-018437-yjvwa1ot 9 12 from from IN cord-018437-yjvwa1ot 9 13 technological technological JJ cord-018437-yjvwa1ot 9 14 advances advance NNS cord-018437-yjvwa1ot 9 15 may may MD cord-018437-yjvwa1ot 9 16 be be VB cord-018437-yjvwa1ot 9 17 integrated integrate VBN cord-018437-yjvwa1ot 9 18 into into IN cord-018437-yjvwa1ot 9 19 the the DT cord-018437-yjvwa1ot 9 20 classifi classifi NNP cord-018437-yjvwa1ot 9 21 cation cation NN cord-018437-yjvwa1ot 9 22 scheme scheme NN cord-018437-yjvwa1ot 9 23 . . . cord-018437-yjvwa1ot 10 1 Primary primary JJ cord-018437-yjvwa1ot 10 2 goals goal NNS cord-018437-yjvwa1ot 10 3 of of IN cord-018437-yjvwa1ot 10 4 systemic systemic JJ cord-018437-yjvwa1ot 10 5 taxonomy taxonomy NN cord-018437-yjvwa1ot 10 6 , , , cord-018437-yjvwa1ot 10 7 regardless regardless RB cord-018437-yjvwa1ot 10 8 of of IN cord-018437-yjvwa1ot 10 9 biological biological JJ cord-018437-yjvwa1ot 10 10 discipline discipline NN cord-018437-yjvwa1ot 10 11 , , , cord-018437-yjvwa1ot 10 12 include include VBP cord-018437-yjvwa1ot 10 13 the the DT cord-018437-yjvwa1ot 10 14 following follow VBG cord-018437-yjvwa1ot 10 15 : : : cord-018437-yjvwa1ot 10 16 • • NNS cord-018437-yjvwa1ot 10 17 Establishing establish VBG cord-018437-yjvwa1ot 10 18 groups group NNS cord-018437-yjvwa1ot 10 19 ( ( -LRB- cord-018437-yjvwa1ot 10 20 taxa taxon NNS cord-018437-yjvwa1ot 10 21 ) ) -RRB- cord-018437-yjvwa1ot 10 22 that that WDT cord-018437-yjvwa1ot 10 23 refl refl NNP cord-018437-yjvwa1ot 10 24 ect ect DT cord-018437-yjvwa1ot 10 25 varying vary VBG cord-018437-yjvwa1ot 10 26 degrees degree NNS cord-018437-yjvwa1ot 10 27 of of IN cord-018437-yjvwa1ot 10 28 evolutionary evolutionary JJ cord-018437-yjvwa1ot 10 29 relatedness relatedness NN cord-018437-yjvwa1ot 10 30 among among IN cord-018437-yjvwa1ot 10 31 the the DT cord-018437-yjvwa1ot 10 32 different different JJ cord-018437-yjvwa1ot 10 33 biological biological JJ cord-018437-yjvwa1ot 10 34 entities entity NNS cord-018437-yjvwa1ot 10 35 studied study VBD cord-018437-yjvwa1ot 10 36 • • NNP cord-018437-yjvwa1ot 10 37 Establishing establish VBG cord-018437-yjvwa1ot 10 38 criteria criterion NNS cord-018437-yjvwa1ot 10 39 for for IN cord-018437-yjvwa1ot 10 40 assignment assignment NN cord-018437-yjvwa1ot 10 41 of of IN cord-018437-yjvwa1ot 10 42 known know VBN cord-018437-yjvwa1ot 10 43 or or CC cord-018437-yjvwa1ot 10 44 unknown unknown JJ cord-018437-yjvwa1ot 10 45 clinical clinical JJ cord-018437-yjvwa1ot 10 46 isolates isolate NNS cord-018437-yjvwa1ot 10 47 to to IN cord-018437-yjvwa1ot 10 48 a a DT cord-018437-yjvwa1ot 10 49 given give VBN cord-018437-yjvwa1ot 10 50 group group NN cord-018437-yjvwa1ot 11 1 • • NNP cord-018437-yjvwa1ot 12 1 Establishing establish VBG cord-018437-yjvwa1ot 12 2 a a DT cord-018437-yjvwa1ot 12 3 clear clear JJ cord-018437-yjvwa1ot 12 4 and and CC cord-018437-yjvwa1ot 12 5 unequivocal unequivocal JJ cord-018437-yjvwa1ot 12 6 nomenclature nomenclature NN cord-018437-yjvwa1ot 13 1 The the DT cord-018437-yjvwa1ot 13 2 origins origin NNS cord-018437-yjvwa1ot 13 3 of of IN cord-018437-yjvwa1ot 13 4 biological biological JJ cord-018437-yjvwa1ot 13 5 taxonomy taxonomy NN cord-018437-yjvwa1ot 13 6 are be VBP cord-018437-yjvwa1ot 13 7 fi fi NNP cord-018437-yjvwa1ot 13 8 rmly rmly NNP cord-018437-yjvwa1ot 13 9 rooted root VBN cord-018437-yjvwa1ot 13 10 in in IN cord-018437-yjvwa1ot 13 11 botany botany NN cord-018437-yjvwa1ot 13 12 and and CC cord-018437-yjvwa1ot 13 13 zoology zoology NN cord-018437-yjvwa1ot 13 14 . . . cord-018437-yjvwa1ot 14 1 Early early JJ cord-018437-yjvwa1ot 14 2 taxonomic taxonomic JJ cord-018437-yjvwa1ot 14 3 systems system NNS cord-018437-yjvwa1ot 14 4 relied rely VBD cord-018437-yjvwa1ot 14 5 on on IN cord-018437-yjvwa1ot 14 6 gross gross JJ cord-018437-yjvwa1ot 14 7 characteristics characteristic NNS cord-018437-yjvwa1ot 14 8 , , , cord-018437-yjvwa1ot 14 9 like like IN cord-018437-yjvwa1ot 14 10 biological biological JJ cord-018437-yjvwa1ot 14 11 niche niche NN cord-018437-yjvwa1ot 14 12 , , , cord-018437-yjvwa1ot 14 13 internal internal JJ cord-018437-yjvwa1ot 14 14 and and CC cord-018437-yjvwa1ot 14 15 external external JJ cord-018437-yjvwa1ot 14 16 morphology morphology NN cord-018437-yjvwa1ot 14 17 , , , cord-018437-yjvwa1ot 14 18 reproductive reproductive JJ cord-018437-yjvwa1ot 14 19 strategies strategy NNS cord-018437-yjvwa1ot 14 20 and and CC cord-018437-yjvwa1ot 14 21 compatibilities compatibility NNS cord-018437-yjvwa1ot 14 22 , , , cord-018437-yjvwa1ot 14 23 and and CC cord-018437-yjvwa1ot 14 24 fossil fossil NN cord-018437-yjvwa1ot 14 25 records record NNS cord-018437-yjvwa1ot 14 26 . . . cord-018437-yjvwa1ot 15 1 The the DT cord-018437-yjvwa1ot 15 2 seminal seminal JJ cord-018437-yjvwa1ot 15 3 works work NNS cord-018437-yjvwa1ot 15 4 of of IN cord-018437-yjvwa1ot 15 5 the the DT cord-018437-yjvwa1ot 15 6 Swedish swedish JJ cord-018437-yjvwa1ot 15 7 botanist botanist NN cord-018437-yjvwa1ot 15 8 Carl Carl NNP cord-018437-yjvwa1ot 15 9 Linnaeus Linnaeus NNP cord-018437-yjvwa1ot 15 10 used use VBD cord-018437-yjvwa1ot 15 11 a a DT cord-018437-yjvwa1ot 15 12 hierarchical hierarchical JJ cord-018437-yjvwa1ot 15 13 scheme scheme NN cord-018437-yjvwa1ot 15 14 to to TO cord-018437-yjvwa1ot 15 15 represent represent VB cord-018437-yjvwa1ot 15 16 biological biological JJ cord-018437-yjvwa1ot 15 17 relatedness relatedness NN cord-018437-yjvwa1ot 15 18 and and CC cord-018437-yjvwa1ot 15 19 established establish VBD cord-018437-yjvwa1ot 15 20 the the DT cord-018437-yjvwa1ot 15 21 simplifi simplifi NNP cord-018437-yjvwa1ot 15 22 ed ed NNP cord-018437-yjvwa1ot 15 23 binomial binomial NNP cord-018437-yjvwa1ot 15 24 system system NN cord-018437-yjvwa1ot 15 25 of of IN cord-018437-yjvwa1ot 15 26 nomenclature nomenclature NN cord-018437-yjvwa1ot 15 27 that that WDT cord-018437-yjvwa1ot 15 28 serves serve VBZ cord-018437-yjvwa1ot 15 29 as as IN cord-018437-yjvwa1ot 15 30 the the DT cord-018437-yjvwa1ot 15 31 basis basis NN cord-018437-yjvwa1ot 15 32 for for IN cord-018437-yjvwa1ot 15 33 modern modern JJ cord-018437-yjvwa1ot 15 34 classifi classifi NNP cord-018437-yjvwa1ot 15 35 cation cation NN cord-018437-yjvwa1ot 15 36 systems system NNS cord-018437-yjvwa1ot 15 37 . . . cord-018437-yjvwa1ot 16 1 The the DT cord-018437-yjvwa1ot 16 2 modern modern JJ cord-018437-yjvwa1ot 16 3 scientifi scientifi NN cord-018437-yjvwa1ot 16 4 c c NNP cord-018437-yjvwa1ot 16 5 classifi classifi NNP cord-018437-yjvwa1ot 16 6 cation cation NN cord-018437-yjvwa1ot 16 7 in in IN cord-018437-yjvwa1ot 16 8 biology biology NN cord-018437-yjvwa1ot 16 9 is be VBZ cord-018437-yjvwa1ot 16 10 designed design VBN cord-018437-yjvwa1ot 16 11 to to TO cord-018437-yjvwa1ot 16 12 describe describe VB cord-018437-yjvwa1ot 16 13 all all DT cord-018437-yjvwa1ot 16 14 biological biological JJ cord-018437-yjvwa1ot 16 15 entities entity NNS cord-018437-yjvwa1ot 16 16 within within IN cord-018437-yjvwa1ot 16 17 a a DT cord-018437-yjvwa1ot 16 18 hierarchy hierarchy NN cord-018437-yjvwa1ot 16 19 consisting consist VBG cord-018437-yjvwa1ot 16 20 of of IN cord-018437-yjvwa1ot 16 21 the the DT cord-018437-yjvwa1ot 16 22 following follow VBG cord-018437-yjvwa1ot 16 23 taxa taxon NNS cord-018437-yjvwa1ot 16 24 : : : cord-018437-yjvwa1ot 17 1 A a DT cord-018437-yjvwa1ot 17 2 basic basic JJ cord-018437-yjvwa1ot 17 3 assumption assumption NN cord-018437-yjvwa1ot 17 4 for for IN cord-018437-yjvwa1ot 17 5 the the DT cord-018437-yjvwa1ot 17 6 establishment establishment NN cord-018437-yjvwa1ot 17 7 of of IN cord-018437-yjvwa1ot 17 8 such such PDT cord-018437-yjvwa1ot 17 9 a a DT cord-018437-yjvwa1ot 17 10 hierarchy hierarchy NN cord-018437-yjvwa1ot 17 11 assumes assume VBZ cord-018437-yjvwa1ot 17 12 that that IN cord-018437-yjvwa1ot 17 13 all all DT cord-018437-yjvwa1ot 17 14 biological biological JJ cord-018437-yjvwa1ot 17 15 entities entity NNS cord-018437-yjvwa1ot 17 16 have have VBP cord-018437-yjvwa1ot 17 17 evolved evolve VBN cord-018437-yjvwa1ot 17 18 from from IN cord-018437-yjvwa1ot 17 19 a a DT cord-018437-yjvwa1ot 17 20 single single JJ cord-018437-yjvwa1ot 17 21 common common JJ cord-018437-yjvwa1ot 17 22 cellular cellular JJ cord-018437-yjvwa1ot 17 23 life life NN cord-018437-yjvwa1ot 17 24 - - HYPH cord-018437-yjvwa1ot 17 25 form form NN cord-018437-yjvwa1ot 17 26 . . . cord-018437-yjvwa1ot 18 1 Different different JJ cord-018437-yjvwa1ot 18 2 biological biological JJ cord-018437-yjvwa1ot 18 3 entities entity NNS cord-018437-yjvwa1ot 18 4 have have VBP cord-018437-yjvwa1ot 18 5 evolved evolve VBN cord-018437-yjvwa1ot 18 6 as as IN cord-018437-yjvwa1ot 18 7 a a DT cord-018437-yjvwa1ot 18 8 result result NN cord-018437-yjvwa1ot 18 9 of of IN cord-018437-yjvwa1ot 18 10 accumulated accumulate VBN cord-018437-yjvwa1ot 18 11 changes change NNS cord-018437-yjvwa1ot 18 12 in in IN cord-018437-yjvwa1ot 18 13 DNA DNA NNP cord-018437-yjvwa1ot 18 14 that that WDT cord-018437-yjvwa1ot 18 15 have have VBP cord-018437-yjvwa1ot 18 16 provided provide VBN cord-018437-yjvwa1ot 18 17 survival survival NN cord-018437-yjvwa1ot 18 18 advantages advantage NNS cord-018437-yjvwa1ot 18 19 in in IN cord-018437-yjvwa1ot 18 20 different different JJ cord-018437-yjvwa1ot 18 21 ecological ecological JJ cord-018437-yjvwa1ot 18 22 niches niche NNS cord-018437-yjvwa1ot 18 23 . . . cord-018437-yjvwa1ot 19 1 Species specie NNS cord-018437-yjvwa1ot 19 2 may may MD cord-018437-yjvwa1ot 19 3 be be VB cord-018437-yjvwa1ot 19 4 classifi classifi NNP cord-018437-yjvwa1ot 19 5 ed ed NNP cord-018437-yjvwa1ot 19 6 on on IN cord-018437-yjvwa1ot 19 7 the the DT cord-018437-yjvwa1ot 19 8 basis basis NN cord-018437-yjvwa1ot 19 9 of of IN cord-018437-yjvwa1ot 19 10 phylogenetic phylogenetic JJ cord-018437-yjvwa1ot 19 11 and and CC cord-018437-yjvwa1ot 19 12 evolutionary evolutionary JJ cord-018437-yjvwa1ot 19 13 relatedness relatedness NN cord-018437-yjvwa1ot 19 14 : : : cord-018437-yjvwa1ot 19 15 members member NNS cord-018437-yjvwa1ot 19 16 of of IN cord-018437-yjvwa1ot 19 17 a a DT cord-018437-yjvwa1ot 19 18 given give VBN cord-018437-yjvwa1ot 19 19 species specie NNS cord-018437-yjvwa1ot 19 20 are be VBP cord-018437-yjvwa1ot 19 21 the the DT cord-018437-yjvwa1ot 19 22 most most RBS cord-018437-yjvwa1ot 19 23 closely closely RB cord-018437-yjvwa1ot 19 24 related related JJ cord-018437-yjvwa1ot 19 25 , , , cord-018437-yjvwa1ot 19 26 different different JJ cord-018437-yjvwa1ot 19 27 species specie NNS cord-018437-yjvwa1ot 19 28 within within IN cord-018437-yjvwa1ot 19 29 a a DT cord-018437-yjvwa1ot 19 30 single single JJ cord-018437-yjvwa1ot 19 31 genus genus NN cord-018437-yjvwa1ot 19 32 are be VBP cord-018437-yjvwa1ot 19 33 more more RBR cord-018437-yjvwa1ot 19 34 closely closely RB cord-018437-yjvwa1ot 19 35 related related JJ cord-018437-yjvwa1ot 19 36 to to IN cord-018437-yjvwa1ot 19 37 each each DT cord-018437-yjvwa1ot 19 38 other other JJ cord-018437-yjvwa1ot 19 39 than than IN cord-018437-yjvwa1ot 19 40 to to IN cord-018437-yjvwa1ot 19 41 a a DT cord-018437-yjvwa1ot 19 42 species species NN cord-018437-yjvwa1ot 19 43 within within IN cord-018437-yjvwa1ot 19 44 a a DT cord-018437-yjvwa1ot 19 45 different different JJ cord-018437-yjvwa1ot 19 46 genus genus NN cord-018437-yjvwa1ot 19 47 , , , cord-018437-yjvwa1ot 19 48 and and CC cord-018437-yjvwa1ot 19 49 so so RB cord-018437-yjvwa1ot 19 50 on on RB cord-018437-yjvwa1ot 19 51 . . . cord-018437-yjvwa1ot 20 1 Newer newer JJ cord-018437-yjvwa1ot 20 2 technologies technology NNS cord-018437-yjvwa1ot 20 3 like like IN cord-018437-yjvwa1ot 20 4 microscopy microscopy NNS cord-018437-yjvwa1ot 20 5 , , , cord-018437-yjvwa1ot 20 6 improved improve VBN cord-018437-yjvwa1ot 20 7 biochemical biochemical JJ cord-018437-yjvwa1ot 20 8 and and CC cord-018437-yjvwa1ot 20 9 physiological physiological JJ cord-018437-yjvwa1ot 20 10 analysis analysis NN cord-018437-yjvwa1ot 20 11 , , , cord-018437-yjvwa1ot 20 12 and and CC cord-018437-yjvwa1ot 20 13 advanced advanced JJ cord-018437-yjvwa1ot 20 14 protein protein NN cord-018437-yjvwa1ot 20 15 and and CC cord-018437-yjvwa1ot 20 16 molecular molecular JJ cord-018437-yjvwa1ot 20 17 analytical analytical JJ cord-018437-yjvwa1ot 20 18 methods method NNS cord-018437-yjvwa1ot 20 19 have have VBP cord-018437-yjvwa1ot 20 20 resulted result VBN cord-018437-yjvwa1ot 20 21 in in IN cord-018437-yjvwa1ot 20 22 an an DT cord-018437-yjvwa1ot 20 23 enormous enormous JJ cord-018437-yjvwa1ot 20 24 expansion expansion NN cord-018437-yjvwa1ot 20 25 of of IN cord-018437-yjvwa1ot 20 26 characteristics characteristic NNS cord-018437-yjvwa1ot 20 27 that that WDT cord-018437-yjvwa1ot 20 28 may may MD cord-018437-yjvwa1ot 20 29 be be VB cord-018437-yjvwa1ot 20 30 studied study VBN cord-018437-yjvwa1ot 20 31 for for IN cord-018437-yjvwa1ot 20 32 the the DT cord-018437-yjvwa1ot 20 33 classifi classifi NNP cord-018437-yjvwa1ot 20 34 cation cation NN cord-018437-yjvwa1ot 20 35 of of IN cord-018437-yjvwa1ot 20 36 biological biological JJ cord-018437-yjvwa1ot 20 37 entities entity NNS cord-018437-yjvwa1ot 20 38 and and CC cord-018437-yjvwa1ot 20 39 validation validation NN cord-018437-yjvwa1ot 20 40 of of IN cord-018437-yjvwa1ot 20 41 taxonomic taxonomic JJ cord-018437-yjvwa1ot 20 42 systems system NNS cord-018437-yjvwa1ot 21 1 ( ( -LRB- cord-018437-yjvwa1ot 21 2 Woese Woese NNP cord-018437-yjvwa1ot 21 3 et et NNP cord-018437-yjvwa1ot 21 4 al al NNP cord-018437-yjvwa1ot 21 5 . . NNP cord-018437-yjvwa1ot 21 6 1990 1990 CD cord-018437-yjvwa1ot 21 7 ) ) -RRB- cord-018437-yjvwa1ot 21 8 . . . cord-018437-yjvwa1ot 22 1 There there EX cord-018437-yjvwa1ot 22 2 are be VBP cord-018437-yjvwa1ot 22 3 a a DT cord-018437-yjvwa1ot 22 4 number number NN cord-018437-yjvwa1ot 22 5 of of IN cord-018437-yjvwa1ot 22 6 excellent excellent JJ cord-018437-yjvwa1ot 22 7 texts text NNS cord-018437-yjvwa1ot 22 8 that that WDT cord-018437-yjvwa1ot 22 9 discuss discuss VBP cord-018437-yjvwa1ot 22 10 the the DT cord-018437-yjvwa1ot 22 11 clinical clinical JJ cord-018437-yjvwa1ot 22 12 and and CC cord-018437-yjvwa1ot 22 13 laboratory laboratory NN cord-018437-yjvwa1ot 22 14 aspects aspect NNS cord-018437-yjvwa1ot 22 15 of of IN cord-018437-yjvwa1ot 22 16 virus virus NN cord-018437-yjvwa1ot 22 17 biology biology NN cord-018437-yjvwa1ot 22 18 ( ( -LRB- cord-018437-yjvwa1ot 22 19 Knipe Knipe NNP cord-018437-yjvwa1ot 22 20 and and CC cord-018437-yjvwa1ot 22 21 Howley Howley NNP cord-018437-yjvwa1ot 22 22 2007 2007 CD cord-018437-yjvwa1ot 22 23 ; ; : cord-018437-yjvwa1ot 22 24 Richman Richman NNP cord-018437-yjvwa1ot 22 25 et et NNP cord-018437-yjvwa1ot 22 26 al al NNP cord-018437-yjvwa1ot 22 27 . . . cord-018437-yjvwa1ot 22 28 2009 2009 CD cord-018437-yjvwa1ot 22 29 ; ; : cord-018437-yjvwa1ot 22 30 Versalovic Versalovic NNP cord-018437-yjvwa1ot 22 31 2012 2012 CD cord-018437-yjvwa1ot 22 32 ) ) -RRB- cord-018437-yjvwa1ot 22 33 . . . cord-018437-yjvwa1ot 23 1 Though though IN cord-018437-yjvwa1ot 23 2 viruses virus NNS cord-018437-yjvwa1ot 23 3 are be VBP cord-018437-yjvwa1ot 23 4 certainly certainly RB cord-018437-yjvwa1ot 23 5 " " `` cord-018437-yjvwa1ot 23 6 biological biological JJ cord-018437-yjvwa1ot 23 7 entities entity NNS cord-018437-yjvwa1ot 23 8 , , , cord-018437-yjvwa1ot 23 9 " " '' cord-018437-yjvwa1ot 23 10 they -PRON- PRP cord-018437-yjvwa1ot 23 11 are be VBP cord-018437-yjvwa1ot 23 12 fundamentally fundamentally RB cord-018437-yjvwa1ot 23 13 different different JJ cord-018437-yjvwa1ot 23 14 from from IN cord-018437-yjvwa1ot 23 15 the the DT cord-018437-yjvwa1ot 23 16 cellular cellular JJ cord-018437-yjvwa1ot 23 17 life life NN cord-018437-yjvwa1ot 23 18 - - HYPH cord-018437-yjvwa1ot 23 19 forms form NNS cord-018437-yjvwa1ot 23 20 classifi classifi NNS cord-018437-yjvwa1ot 23 21 ed ed NN cord-018437-yjvwa1ot 23 22 by by IN cord-018437-yjvwa1ot 23 23 previous previous JJ cord-018437-yjvwa1ot 23 24 taxonomic taxonomic JJ cord-018437-yjvwa1ot 23 25 schemes scheme NNS cord-018437-yjvwa1ot 23 26 . . . cord-018437-yjvwa1ot 24 1 Viruses virus NNS cord-018437-yjvwa1ot 24 2 have have VBP cord-018437-yjvwa1ot 24 3 no no DT cord-018437-yjvwa1ot 24 4 autonomous autonomous JJ cord-018437-yjvwa1ot 24 5 metabolic metabolic JJ cord-018437-yjvwa1ot 24 6 or or CC cord-018437-yjvwa1ot 24 7 replicative replicative JJ cord-018437-yjvwa1ot 24 8 ability ability NN cord-018437-yjvwa1ot 24 9 ; ; : cord-018437-yjvwa1ot 24 10 they -PRON- PRP cord-018437-yjvwa1ot 24 11 are be VBP cord-018437-yjvwa1ot 24 12 completely completely RB cord-018437-yjvwa1ot 24 13 dependent dependent JJ cord-018437-yjvwa1ot 24 14 on on IN cord-018437-yjvwa1ot 24 15 cellular cellular JJ cord-018437-yjvwa1ot 24 16 life life NN cord-018437-yjvwa1ot 24 17 - - HYPH cord-018437-yjvwa1ot 24 18 forms form NNS cord-018437-yjvwa1ot 24 19 . . . cord-018437-yjvwa1ot 25 1 However however RB cord-018437-yjvwa1ot 25 2 , , , cord-018437-yjvwa1ot 25 3 within within IN cord-018437-yjvwa1ot 25 4 their -PRON- PRP$ cord-018437-yjvwa1ot 25 5 biological biological JJ cord-018437-yjvwa1ot 25 6 milieu milieu NN cord-018437-yjvwa1ot 25 7 , , , cord-018437-yjvwa1ot 25 8 viruses virus NNS cord-018437-yjvwa1ot 25 9 do do VBP cord-018437-yjvwa1ot 25 10 replicate replicate VB cord-018437-yjvwa1ot 25 11 and and CC cord-018437-yjvwa1ot 25 12 evolve evolve VB cord-018437-yjvwa1ot 25 13 , , , cord-018437-yjvwa1ot 25 14 and and CC cord-018437-yjvwa1ot 25 15 they -PRON- PRP cord-018437-yjvwa1ot 25 16 are be VBP cord-018437-yjvwa1ot 25 17 composed compose VBN cord-018437-yjvwa1ot 25 18 of of IN cord-018437-yjvwa1ot 25 19 the the DT cord-018437-yjvwa1ot 25 20 same same JJ cord-018437-yjvwa1ot 25 21 types type NNS cord-018437-yjvwa1ot 25 22 of of IN cord-018437-yjvwa1ot 25 23 organic organic JJ cord-018437-yjvwa1ot 25 24 macromolecules macromolecule NNS cord-018437-yjvwa1ot 25 25 as as IN cord-018437-yjvwa1ot 25 26 are be VBP cord-018437-yjvwa1ot 25 27 cellular cellular JJ cord-018437-yjvwa1ot 25 28 lifeforms lifeform NNS cord-018437-yjvwa1ot 25 29 . . . cord-018437-yjvwa1ot 26 1 Because because IN cord-018437-yjvwa1ot 26 2 of of IN cord-018437-yjvwa1ot 26 3 their -PRON- PRP$ cord-018437-yjvwa1ot 26 4 intimate intimate JJ cord-018437-yjvwa1ot 26 5 relationship relationship NN cord-018437-yjvwa1ot 26 6 with with IN cord-018437-yjvwa1ot 26 7 cellular cellular JJ cord-018437-yjvwa1ot 26 8 life life NN cord-018437-yjvwa1ot 26 9 - - HYPH cord-018437-yjvwa1ot 26 10 forms form NNS cord-018437-yjvwa1ot 26 11 , , , cord-018437-yjvwa1ot 26 12 it -PRON- PRP cord-018437-yjvwa1ot 26 13 seems seem VBZ cord-018437-yjvwa1ot 26 14 legitimate legitimate JJ cord-018437-yjvwa1ot 26 15 to to TO cord-018437-yjvwa1ot 26 16 integrate integrate VB cord-018437-yjvwa1ot 26 17 the the DT cord-018437-yjvwa1ot 26 18 schemes scheme NNS cord-018437-yjvwa1ot 26 19 for for IN cord-018437-yjvwa1ot 26 20 classifi classifi NNP cord-018437-yjvwa1ot 26 21 cation cation NN cord-018437-yjvwa1ot 26 22 of of IN cord-018437-yjvwa1ot 26 23 viruses virus NNS cord-018437-yjvwa1ot 26 24 with with IN cord-018437-yjvwa1ot 26 25 the the DT cord-018437-yjvwa1ot 26 26 schemes scheme NNS cord-018437-yjvwa1ot 26 27 used use VBN cord-018437-yjvwa1ot 26 28 for for IN cord-018437-yjvwa1ot 26 29 biological biological JJ cord-018437-yjvwa1ot 26 30 classifi classifi NNP cord-018437-yjvwa1ot 26 31 cation cation NN cord-018437-yjvwa1ot 26 32 of of IN cord-018437-yjvwa1ot 26 33 cellular cellular JJ cord-018437-yjvwa1ot 26 34 life life NN cord-018437-yjvwa1ot 26 35 - - HYPH cord-018437-yjvwa1ot 26 36 forms form NNS cord-018437-yjvwa1ot 26 37 ( ( -LRB- cord-018437-yjvwa1ot 26 38 Lefkowitz Lefkowitz NNP cord-018437-yjvwa1ot 26 39 2012 2012 CD cord-018437-yjvwa1ot 26 40 ) ) -RRB- cord-018437-yjvwa1ot 26 41 . . . cord-018437-yjvwa1ot 27 1 Initially initially RB cord-018437-yjvwa1ot 27 2 , , , cord-018437-yjvwa1ot 27 3 various various JJ cord-018437-yjvwa1ot 27 4 features feature NNS cord-018437-yjvwa1ot 27 5 , , , cord-018437-yjvwa1ot 27 6 like like IN cord-018437-yjvwa1ot 27 7 host host NN cord-018437-yjvwa1ot 27 8 range range NN cord-018437-yjvwa1ot 27 9 , , , cord-018437-yjvwa1ot 27 10 crossimmunity crossimmunity NN cord-018437-yjvwa1ot 27 11 , , , cord-018437-yjvwa1ot 27 12 clinical clinical JJ cord-018437-yjvwa1ot 27 13 disease disease NN cord-018437-yjvwa1ot 27 14 , , , cord-018437-yjvwa1ot 27 15 and and CC cord-018437-yjvwa1ot 27 16 pathologic pathologic JJ cord-018437-yjvwa1ot 27 17 features feature NNS cord-018437-yjvwa1ot 27 18 , , , cord-018437-yjvwa1ot 27 19 were be VBD cord-018437-yjvwa1ot 27 20 used use VBN cord-018437-yjvwa1ot 27 21 to to TO cord-018437-yjvwa1ot 27 22 classify classify VB cord-018437-yjvwa1ot 27 23 viruses virus NNS cord-018437-yjvwa1ot 27 24 . . . cord-018437-yjvwa1ot 28 1 Technological technological JJ cord-018437-yjvwa1ot 28 2 advances advance NNS cord-018437-yjvwa1ot 28 3 have have VBP cord-018437-yjvwa1ot 28 4 led lead VBN cord-018437-yjvwa1ot 28 5 to to IN cord-018437-yjvwa1ot 28 6 more more RBR cord-018437-yjvwa1ot 28 7 detailed detailed JJ cord-018437-yjvwa1ot 28 8 and and CC cord-018437-yjvwa1ot 28 9 integrated integrated JJ cord-018437-yjvwa1ot 28 10 classifi classifi NNP cord-018437-yjvwa1ot 28 11 cation cation NN cord-018437-yjvwa1ot 28 12 , , , cord-018437-yjvwa1ot 28 13 taxonomy taxonomy NN cord-018437-yjvwa1ot 28 14 , , , cord-018437-yjvwa1ot 28 15 and and CC cord-018437-yjvwa1ot 28 16 phylogenetic phylogenetic JJ cord-018437-yjvwa1ot 28 17 characterization characterization NN cord-018437-yjvwa1ot 28 18 ( ( -LRB- cord-018437-yjvwa1ot 28 19 evolutionary evolutionary JJ cord-018437-yjvwa1ot 28 20 relatedness relatedness NN cord-018437-yjvwa1ot 28 21 ) ) -RRB- cord-018437-yjvwa1ot 28 22 of of IN cord-018437-yjvwa1ot 28 23 viruses virus NNS cord-018437-yjvwa1ot 28 24 . . . cord-018437-yjvwa1ot 29 1 Sophisticated sophisticated JJ cord-018437-yjvwa1ot 29 2 nucleic nucleic JJ cord-018437-yjvwa1ot 29 3 acid acid NN cord-018437-yjvwa1ot 29 4 sequence sequence NN cord-018437-yjvwa1ot 29 5 analysis analysis NN cord-018437-yjvwa1ot 29 6 has have VBZ cord-018437-yjvwa1ot 29 7 emerged emerge VBN cord-018437-yjvwa1ot 29 8 as as IN cord-018437-yjvwa1ot 29 9 a a DT cord-018437-yjvwa1ot 29 10 powerful powerful JJ cord-018437-yjvwa1ot 29 11 tool tool NN cord-018437-yjvwa1ot 29 12 for for IN cord-018437-yjvwa1ot 29 13 virus virus NNP cord-018437-yjvwa1ot 29 14 classifi classifi NNP cord-018437-yjvwa1ot 29 15 cation cation NNP cord-018437-yjvwa1ot 29 16 and and CC cord-018437-yjvwa1ot 29 17 phylogenetic phylogenetic JJ cord-018437-yjvwa1ot 29 18 determination determination NN cord-018437-yjvwa1ot 29 19 , , , cord-018437-yjvwa1ot 29 20 in in IN cord-018437-yjvwa1ot 29 21 spite spite NN cord-018437-yjvwa1ot 29 22 of of IN cord-018437-yjvwa1ot 29 23 some some DT cord-018437-yjvwa1ot 29 24 limitations limitation NNS cord-018437-yjvwa1ot 29 25 ( ( -LRB- cord-018437-yjvwa1ot 29 26 Holmes Holmes NNP cord-018437-yjvwa1ot 29 27 2008 2008 CD cord-018437-yjvwa1ot 29 28 ; ; : cord-018437-yjvwa1ot 29 29 McCormack McCormack NNP cord-018437-yjvwa1ot 29 30 and and CC cord-018437-yjvwa1ot 29 31 Clewley Clewley NNP cord-018437-yjvwa1ot 29 32 2002 2002 CD cord-018437-yjvwa1ot 29 33 ; ; : cord-018437-yjvwa1ot 29 34 Zanotto Zanotto NNP cord-018437-yjvwa1ot 29 35 et et NNP cord-018437-yjvwa1ot 29 36 al al NNP cord-018437-yjvwa1ot 29 37 . . . cord-018437-yjvwa1ot 29 38 1996 1996 CD cord-018437-yjvwa1ot 29 39 ) ) -RRB- cord-018437-yjvwa1ot 29 40 . . . cord-018437-yjvwa1ot 30 1 A a DT cord-018437-yjvwa1ot 30 2 robust robust JJ cord-018437-yjvwa1ot 30 3 system system NN cord-018437-yjvwa1ot 30 4 for for IN cord-018437-yjvwa1ot 30 5 classifi classifi NNP cord-018437-yjvwa1ot 30 6 cation cation NN cord-018437-yjvwa1ot 30 7 of of IN cord-018437-yjvwa1ot 30 8 viruses virus NNS cord-018437-yjvwa1ot 30 9 developed develop VBN cord-018437-yjvwa1ot 30 10 by by IN cord-018437-yjvwa1ot 30 11 David David NNP cord-018437-yjvwa1ot 30 12 Baltimore Baltimore NNP cord-018437-yjvwa1ot 30 13 has have VBZ cord-018437-yjvwa1ot 30 14 gained gain VBN cord-018437-yjvwa1ot 30 15 wide wide JJ cord-018437-yjvwa1ot 30 16 acceptance acceptance NN cord-018437-yjvwa1ot 30 17 ( ( -LRB- cord-018437-yjvwa1ot 30 18 Baltimore Baltimore NNP cord-018437-yjvwa1ot 30 19 1971 1971 CD cord-018437-yjvwa1ot 30 20 ) ) -RRB- cord-018437-yjvwa1ot 30 21 . . . cord-018437-yjvwa1ot 31 1 Classifi Classifi NNP cord-018437-yjvwa1ot 31 2 cation cation NN cord-018437-yjvwa1ot 31 3 is be VBZ cord-018437-yjvwa1ot 31 4 based base VBN cord-018437-yjvwa1ot 31 5 on on IN cord-018437-yjvwa1ot 31 6 the the DT cord-018437-yjvwa1ot 31 7 genomic genomic JJ cord-018437-yjvwa1ot 31 8 nucleic nucleic JJ cord-018437-yjvwa1ot 31 9 acid acid NN cord-018437-yjvwa1ot 31 10 used use VBN cord-018437-yjvwa1ot 31 11 by by IN cord-018437-yjvwa1ot 31 12 the the DT cord-018437-yjvwa1ot 31 13 virus virus NN cord-018437-yjvwa1ot 31 14 ( ( -LRB- cord-018437-yjvwa1ot 31 15 DNA DNA NNP cord-018437-yjvwa1ot 31 16 or or CC cord-018437-yjvwa1ot 31 17 RNA RNA NNP cord-018437-yjvwa1ot 31 18 ) ) -RRB- cord-018437-yjvwa1ot 31 19 , , , cord-018437-yjvwa1ot 31 20 strandedness strandedness NNP cord-018437-yjvwa1ot 31 21 ( ( -LRB- cord-018437-yjvwa1ot 31 22 single single JJ cord-018437-yjvwa1ot 31 23 or or CC cord-018437-yjvwa1ot 31 24 double double JJ cord-018437-yjvwa1ot 31 25 stranded strand VBN cord-018437-yjvwa1ot 31 26 ) ) -RRB- cord-018437-yjvwa1ot 31 27 , , , cord-018437-yjvwa1ot 31 28 and and CC cord-018437-yjvwa1ot 31 29 method method NN cord-018437-yjvwa1ot 31 30 of of IN cord-018437-yjvwa1ot 31 31 replication replication NN cord-018437-yjvwa1ot 31 32 . . . cord-018437-yjvwa1ot 32 1 The the DT cord-018437-yjvwa1ot 32 2 system system NN cord-018437-yjvwa1ot 32 3 has have VBZ cord-018437-yjvwa1ot 32 4 been be VBN cord-018437-yjvwa1ot 32 5 used use VBN cord-018437-yjvwa1ot 32 6 to to TO cord-018437-yjvwa1ot 32 7 defi defi NNP cord-018437-yjvwa1ot 32 8 ne ne NNP cord-018437-yjvwa1ot 32 9 seven seven CD cord-018437-yjvwa1ot 32 10 classes class NNS cord-018437-yjvwa1ot 32 11 of of IN cord-018437-yjvwa1ot 32 12 viruses virus NNS cord-018437-yjvwa1ot 32 13 : : : cord-018437-yjvwa1ot 33 1 Class class NN cord-018437-yjvwa1ot 33 2 I i NN cord-018437-yjvwa1ot 33 3 : : : cord-018437-yjvwa1ot 33 4 Double double RB cord-018437-yjvwa1ot 33 5 - - HYPH cord-018437-yjvwa1ot 33 6 stranded strand VBN cord-018437-yjvwa1ot 33 7 DNA dna NN cord-018437-yjvwa1ot 33 8 ( ( -LRB- cord-018437-yjvwa1ot 33 9 dsDNA dsdna RB cord-018437-yjvwa1ot 33 10 ) ) -RRB- cord-018437-yjvwa1ot 33 11 Class class NN cord-018437-yjvwa1ot 33 12 II ii NN cord-018437-yjvwa1ot 33 13 : : : cord-018437-yjvwa1ot 33 14 Single single JJ cord-018437-yjvwa1ot 33 15 - - HYPH cord-018437-yjvwa1ot 33 16 stranded strand VBN cord-018437-yjvwa1ot 33 17 DNA dna NN cord-018437-yjvwa1ot 33 18 ( ( -LRB- cord-018437-yjvwa1ot 33 19 ssDNA ssdna NN cord-018437-yjvwa1ot 33 20 ) ) -RRB- cord-018437-yjvwa1ot 34 1 The the DT cord-018437-yjvwa1ot 34 2 primary primary JJ cord-018437-yjvwa1ot 34 3 classifi classifi NN cord-018437-yjvwa1ot 34 4 cation cation NN cord-018437-yjvwa1ot 34 5 of of IN cord-018437-yjvwa1ot 34 6 viruses virus NNS cord-018437-yjvwa1ot 34 7 is be VBZ cord-018437-yjvwa1ot 34 8 into into IN cord-018437-yjvwa1ot 34 9 species specie NNS cord-018437-yjvwa1ot 34 10 . . . cord-018437-yjvwa1ot 35 1 A a DT cord-018437-yjvwa1ot 35 2 virus virus NN cord-018437-yjvwa1ot 35 3 species species NN cord-018437-yjvwa1ot 35 4 is be VBZ cord-018437-yjvwa1ot 35 5 defi defi NNP cord-018437-yjvwa1ot 35 6 ned ned NNP cord-018437-yjvwa1ot 35 7 as as IN cord-018437-yjvwa1ot 35 8 a a DT cord-018437-yjvwa1ot 35 9 polythetic polythetic JJ cord-018437-yjvwa1ot 35 10 class class NN cord-018437-yjvwa1ot 35 11 of of IN cord-018437-yjvwa1ot 35 12 viruses virus NNS cord-018437-yjvwa1ot 35 13 that that WDT cord-018437-yjvwa1ot 35 14 constitute constitute VBP cord-018437-yjvwa1ot 35 15 a a DT cord-018437-yjvwa1ot 35 16 replicating replicate VBG cord-018437-yjvwa1ot 35 17 lineage lineage NN cord-018437-yjvwa1ot 35 18 and and CC cord-018437-yjvwa1ot 35 19 occupy occupy VB cord-018437-yjvwa1ot 35 20 a a DT cord-018437-yjvwa1ot 35 21 specifi specifi NN cord-018437-yjvwa1ot 35 22 c c NN cord-018437-yjvwa1ot 35 23 ecological ecological JJ cord-018437-yjvwa1ot 35 24 niche niche NN cord-018437-yjvwa1ot 36 1 ( ( -LRB- cord-018437-yjvwa1ot 36 2 International International NNP cord-018437-yjvwa1ot 36 3 Committee Committee NNP cord-018437-yjvwa1ot 36 4 on on IN cord-018437-yjvwa1ot 36 5 Taxonomy Taxonomy NNP cord-018437-yjvwa1ot 36 6 of of IN cord-018437-yjvwa1ot 36 7 Viruses Viruses NNPS cord-018437-yjvwa1ot 36 8 2002 2002 CD cord-018437-yjvwa1ot 36 9 ) ) -RRB- cord-018437-yjvwa1ot 36 10 . . . cord-018437-yjvwa1ot 37 1 In in IN cord-018437-yjvwa1ot 37 2 polythetic polythetic JJ cord-018437-yjvwa1ot 37 3 classifi classifi NNP cord-018437-yjvwa1ot 37 4 cations cation NNS cord-018437-yjvwa1ot 37 5 , , , cord-018437-yjvwa1ot 37 6 group group NN cord-018437-yjvwa1ot 37 7 members member NNS cord-018437-yjvwa1ot 37 8 share share VBP cord-018437-yjvwa1ot 37 9 a a DT cord-018437-yjvwa1ot 37 10 number number NN cord-018437-yjvwa1ot 37 11 of of IN cord-018437-yjvwa1ot 37 12 characteristics characteristic NNS cord-018437-yjvwa1ot 37 13 , , , cord-018437-yjvwa1ot 37 14 but but CC cord-018437-yjvwa1ot 37 15 no no DT cord-018437-yjvwa1ot 37 16 single single JJ cord-018437-yjvwa1ot 37 17 characteristic characteristic NN cord-018437-yjvwa1ot 37 18 is be VBZ cord-018437-yjvwa1ot 37 19 necessary necessary JJ cord-018437-yjvwa1ot 37 20 or or CC cord-018437-yjvwa1ot 37 21 suffi suffi JJ cord-018437-yjvwa1ot 37 22 cient cient NNP cord-018437-yjvwa1ot 37 23 to to IN cord-018437-yjvwa1ot 37 24 defi defi NNP cord-018437-yjvwa1ot 37 25 ne ne NNP cord-018437-yjvwa1ot 37 26 members member NNS cord-018437-yjvwa1ot 37 27 of of IN cord-018437-yjvwa1ot 37 28 the the DT cord-018437-yjvwa1ot 37 29 group group NN cord-018437-yjvwa1ot 37 30 . . . cord-018437-yjvwa1ot 38 1 Higher high JJR cord-018437-yjvwa1ot 38 2 - - HYPH cord-018437-yjvwa1ot 38 3 level level NN cord-018437-yjvwa1ot 38 4 taxa taxon NNS cord-018437-yjvwa1ot 38 5 are be VBP cord-018437-yjvwa1ot 38 6 monothetic monothetic JJ cord-018437-yjvwa1ot 38 7 , , , cord-018437-yjvwa1ot 38 8 i.e. i.e. FW cord-018437-yjvwa1ot 38 9 , , , cord-018437-yjvwa1ot 38 10 there there EX cord-018437-yjvwa1ot 38 11 are be VBP cord-018437-yjvwa1ot 38 12 characteristics characteristic NNS cord-018437-yjvwa1ot 38 13 that that WDT cord-018437-yjvwa1ot 38 14 are be VBP cord-018437-yjvwa1ot 38 15 necessary necessary JJ cord-018437-yjvwa1ot 38 16 and and CC cord-018437-yjvwa1ot 38 17 suffi suffi NNP cord-018437-yjvwa1ot 38 18 cient cient NNP cord-018437-yjvwa1ot 38 19 to to IN cord-018437-yjvwa1ot 38 20 defi defi NNP cord-018437-yjvwa1ot 38 21 ne ne NNP cord-018437-yjvwa1ot 38 22 members member NNS cord-018437-yjvwa1ot 38 23 of of IN cord-018437-yjvwa1ot 38 24 the the DT cord-018437-yjvwa1ot 38 25 class class NN cord-018437-yjvwa1ot 38 26 . . . cord-018437-yjvwa1ot 39 1 It -PRON- PRP cord-018437-yjvwa1ot 39 2 is be VBZ cord-018437-yjvwa1ot 39 3 important important JJ cord-018437-yjvwa1ot 39 4 to to TO cord-018437-yjvwa1ot 39 5 note note VB cord-018437-yjvwa1ot 39 6 that that IN cord-018437-yjvwa1ot 39 7 not not RB cord-018437-yjvwa1ot 39 8 all all DT cord-018437-yjvwa1ot 39 9 viruses virus NNS cord-018437-yjvwa1ot 39 10 can can MD cord-018437-yjvwa1ot 39 11 be be VB cord-018437-yjvwa1ot 39 12 assigned assign VBN cord-018437-yjvwa1ot 39 13 through through IN cord-018437-yjvwa1ot 39 14 all all DT cord-018437-yjvwa1ot 39 15 taxonomic taxonomic JJ cord-018437-yjvwa1ot 39 16 levels level NNS cord-018437-yjvwa1ot 39 17 . . . cord-018437-yjvwa1ot 40 1 Virus virus NN cord-018437-yjvwa1ot 40 2 species specie NNS cord-018437-yjvwa1ot 40 3 may may MD cord-018437-yjvwa1ot 40 4 be be VB cord-018437-yjvwa1ot 40 5 assigned assign VBN cord-018437-yjvwa1ot 40 6 to to IN cord-018437-yjvwa1ot 40 7 a a DT cord-018437-yjvwa1ot 40 8 genus genus NN cord-018437-yjvwa1ot 40 9 or or CC cord-018437-yjvwa1ot 40 10 remain remain VB cord-018437-yjvwa1ot 40 11 unassigned unassigned JJ cord-018437-yjvwa1ot 40 12 . . . cord-018437-yjvwa1ot 41 1 Similarly similarly RB cord-018437-yjvwa1ot 41 2 , , , cord-018437-yjvwa1ot 41 3 a a DT cord-018437-yjvwa1ot 41 4 genus genus NN cord-018437-yjvwa1ot 41 5 may may MD cord-018437-yjvwa1ot 41 6 be be VB cord-018437-yjvwa1ot 41 7 assigned assign VBN cord-018437-yjvwa1ot 41 8 to to IN cord-018437-yjvwa1ot 41 9 a a DT cord-018437-yjvwa1ot 41 10 family family NN cord-018437-yjvwa1ot 41 11 or or CC cord-018437-yjvwa1ot 41 12 subfamily subfamily NN cord-018437-yjvwa1ot 41 13 , , , cord-018437-yjvwa1ot 41 14 or or CC cord-018437-yjvwa1ot 41 15 remain remain VBP cord-018437-yjvwa1ot 41 16 unassigned unassigned JJ cord-018437-yjvwa1ot 41 17 , , , cord-018437-yjvwa1ot 41 18 and and CC cord-018437-yjvwa1ot 41 19 so so RB cord-018437-yjvwa1ot 41 20 on on RB cord-018437-yjvwa1ot 41 21 up up RP cord-018437-yjvwa1ot 41 22 the the DT cord-018437-yjvwa1ot 41 23 taxonomic taxonomic JJ cord-018437-yjvwa1ot 41 24 hierarchy hierarchy NN cord-018437-yjvwa1ot 41 25 . . . cord-018437-yjvwa1ot 42 1 Each each DT cord-018437-yjvwa1ot 42 2 genus genus NN cord-018437-yjvwa1ot 42 3 has have VBZ cord-018437-yjvwa1ot 42 4 a a DT cord-018437-yjvwa1ot 42 5 type type NN cord-018437-yjvwa1ot 42 6 species specie NNS cord-018437-yjvwa1ot 42 7 . . . cord-018437-yjvwa1ot 43 1 The the DT cord-018437-yjvwa1ot 43 2 type type NN cord-018437-yjvwa1ot 43 3 species species NN cord-018437-yjvwa1ot 43 4 is be VBZ cord-018437-yjvwa1ot 43 5 the the DT cord-018437-yjvwa1ot 43 6 virus virus NN cord-018437-yjvwa1ot 43 7 that that WDT cord-018437-yjvwa1ot 43 8 necessitated necessitate VBD cord-018437-yjvwa1ot 43 9 the the DT cord-018437-yjvwa1ot 43 10 creation creation NN cord-018437-yjvwa1ot 43 11 of of IN cord-018437-yjvwa1ot 43 12 the the DT cord-018437-yjvwa1ot 43 13 genus genus NN cord-018437-yjvwa1ot 43 14 ; ; : cord-018437-yjvwa1ot 43 15 it -PRON- PRP cord-018437-yjvwa1ot 43 16 is be VBZ cord-018437-yjvwa1ot 43 17 always always RB cord-018437-yjvwa1ot 43 18 linked link VBN cord-018437-yjvwa1ot 43 19 to to IN cord-018437-yjvwa1ot 43 20 the the DT cord-018437-yjvwa1ot 43 21 genus genus NN cord-018437-yjvwa1ot 43 22 . . . cord-018437-yjvwa1ot 44 1 In in IN cord-018437-yjvwa1ot 44 2 the the DT cord-018437-yjvwa1ot 44 3 most most RBS cord-018437-yjvwa1ot 44 4 recent recent JJ cord-018437-yjvwa1ot 44 5 publication publication NN cord-018437-yjvwa1ot 44 6 ( ( -LRB- cord-018437-yjvwa1ot 44 7 2012 2012 CD cord-018437-yjvwa1ot 44 8 ) ) -RRB- cord-018437-yjvwa1ot 44 9 , , , cord-018437-yjvwa1ot 44 10 the the DT cord-018437-yjvwa1ot 44 11 ICTV ICTV NNP cord-018437-yjvwa1ot 44 12 recognized recognize VBD cord-018437-yjvwa1ot 44 13 7 7 CD cord-018437-yjvwa1ot 44 14 orders order NNS cord-018437-yjvwa1ot 44 15 , , , cord-018437-yjvwa1ot 44 16 96 96 CD cord-018437-yjvwa1ot 44 17 families family NNS cord-018437-yjvwa1ot 44 18 , , , cord-018437-yjvwa1ot 44 19 22 22 CD cord-018437-yjvwa1ot 44 20 subfamilies subfamily NNS cord-018437-yjvwa1ot 44 21 , , , cord-018437-yjvwa1ot 44 22 420 420 CD cord-018437-yjvwa1ot 44 23 genera genus NNS cord-018437-yjvwa1ot 44 24 , , , cord-018437-yjvwa1ot 44 25 and and CC cord-018437-yjvwa1ot 44 26 2,618 2,618 CD cord-018437-yjvwa1ot 44 27 species specie NNS cord-018437-yjvwa1ot 44 28 . . . cord-018437-yjvwa1ot 45 1 Important important JJ cord-018437-yjvwa1ot 45 2 characteristics characteristic NNS cord-018437-yjvwa1ot 45 3 used use VBN cord-018437-yjvwa1ot 45 4 by by IN cord-018437-yjvwa1ot 45 5 the the DT cord-018437-yjvwa1ot 45 6 ICTV ICTV NNP cord-018437-yjvwa1ot 45 7 to to TO cord-018437-yjvwa1ot 45 8 defi defi NNP cord-018437-yjvwa1ot 45 9 ne ne NNP cord-018437-yjvwa1ot 45 10 and and CC cord-018437-yjvwa1ot 45 11 classify classify VB cord-018437-yjvwa1ot 45 12 viruses virus NNS cord-018437-yjvwa1ot 45 13 within within IN cord-018437-yjvwa1ot 45 14 these these DT cord-018437-yjvwa1ot 45 15 taxa taxon NNS cord-018437-yjvwa1ot 45 16 include include VBP cord-018437-yjvwa1ot 45 17 the the DT cord-018437-yjvwa1ot 45 18 following follow VBG cord-018437-yjvwa1ot 45 19 : : : cord-018437-yjvwa1ot 45 20 • • XX cord-018437-yjvwa1ot 46 1 Susceptible susceptible JJ cord-018437-yjvwa1ot 46 2 Host host NN cord-018437-yjvwa1ot 46 3 Range range NN cord-018437-yjvwa1ot 47 1 : : : cord-018437-yjvwa1ot 47 2 Most Most JJS cord-018437-yjvwa1ot 47 3 viruses virus NNS cord-018437-yjvwa1ot 47 4 have have VBP cord-018437-yjvwa1ot 47 5 a a DT cord-018437-yjvwa1ot 47 6 restricted restrict VBN cord-018437-yjvwa1ot 47 7 range range NN cord-018437-yjvwa1ot 47 8 of of IN cord-018437-yjvwa1ot 47 9 hosts host NNS cord-018437-yjvwa1ot 47 10 which which WDT cord-018437-yjvwa1ot 47 11 they -PRON- PRP cord-018437-yjvwa1ot 47 12 are be VBP cord-018437-yjvwa1ot 47 13 able able JJ cord-018437-yjvwa1ot 47 14 to to TO cord-018437-yjvwa1ot 47 15 infect infect VB cord-018437-yjvwa1ot 47 16 . . . cord-018437-yjvwa1ot 48 1 • • NNP cord-018437-yjvwa1ot 49 1 Virus Virus NNP cord-018437-yjvwa1ot 49 2 Structure Structure NNP cord-018437-yjvwa1ot 49 3 : : : cord-018437-yjvwa1ot 49 4 The the DT cord-018437-yjvwa1ot 49 5 viral viral JJ cord-018437-yjvwa1ot 49 6 genome genome NN cord-018437-yjvwa1ot 49 7 is be VBZ cord-018437-yjvwa1ot 49 8 surrounded surround VBN cord-018437-yjvwa1ot 49 9 by by IN cord-018437-yjvwa1ot 49 10 a a DT cord-018437-yjvwa1ot 49 11 protective protective JJ cord-018437-yjvwa1ot 49 12 shell shell NN cord-018437-yjvwa1ot 49 13 of of IN cord-018437-yjvwa1ot 49 14 proteins protein NNS cord-018437-yjvwa1ot 49 15 called call VBD cord-018437-yjvwa1ot 49 16 a a DT cord-018437-yjvwa1ot 49 17 capsid capsid NN cord-018437-yjvwa1ot 49 18 . . . cord-018437-yjvwa1ot 50 1 The the DT cord-018437-yjvwa1ot 50 2 capsid capsid NN cord-018437-yjvwa1ot 50 3 may may MD cord-018437-yjvwa1ot 50 4 also also RB cord-018437-yjvwa1ot 50 5 enclose enclose VB cord-018437-yjvwa1ot 50 6 proteins protein NNS cord-018437-yjvwa1ot 50 7 , , , cord-018437-yjvwa1ot 50 8 like like IN cord-018437-yjvwa1ot 50 9 reverse reverse JJ cord-018437-yjvwa1ot 50 10 transcriptase transcriptase NN cord-018437-yjvwa1ot 50 11 or or CC cord-018437-yjvwa1ot 50 12 proteins protein NNS cord-018437-yjvwa1ot 50 13 required require VBN cord-018437-yjvwa1ot 50 14 for for IN cord-018437-yjvwa1ot 50 15 organization organization NN cord-018437-yjvwa1ot 50 16 of of IN cord-018437-yjvwa1ot 50 17 the the DT cord-018437-yjvwa1ot 50 18 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 50 19 . . . cord-018437-yjvwa1ot 51 1 A a DT cord-018437-yjvwa1ot 51 2 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 51 3 refers refer VBZ cord-018437-yjvwa1ot 51 4 to to IN cord-018437-yjvwa1ot 51 5 a a DT cord-018437-yjvwa1ot 51 6 viral viral JJ cord-018437-yjvwa1ot 51 7 nucleus nucleus NN cord-018437-yjvwa1ot 51 8 surrounded surround VBN cord-018437-yjvwa1ot 51 9 by by IN cord-018437-yjvwa1ot 51 10 an an DT cord-018437-yjvwa1ot 51 11 intact intact JJ cord-018437-yjvwa1ot 51 12 capsid capsid NN cord-018437-yjvwa1ot 51 13 . . . cord-018437-yjvwa1ot 52 1 The the DT cord-018437-yjvwa1ot 52 2 nucleocapsids nucleocapsid NNS cord-018437-yjvwa1ot 52 3 of of IN cord-018437-yjvwa1ot 52 4 certain certain JJ cord-018437-yjvwa1ot 52 5 viruses virus NNS cord-018437-yjvwa1ot 52 6 are be VBP cord-018437-yjvwa1ot 52 7 also also RB cord-018437-yjvwa1ot 52 8 surrounded surround VBN cord-018437-yjvwa1ot 52 9 by by IN cord-018437-yjvwa1ot 52 10 an an DT cord-018437-yjvwa1ot 52 11 envelope envelope NN cord-018437-yjvwa1ot 52 12 of of IN cord-018437-yjvwa1ot 52 13 host host NN cord-018437-yjvwa1ot 52 14 - - HYPH cord-018437-yjvwa1ot 52 15 derived derive VBN cord-018437-yjvwa1ot 52 16 membranes membrane NNS cord-018437-yjvwa1ot 52 17 . . . cord-018437-yjvwa1ot 53 1 The the DT cord-018437-yjvwa1ot 53 2 complete complete JJ cord-018437-yjvwa1ot 53 3 virus virus NN cord-018437-yjvwa1ot 53 4 particle particle NN cord-018437-yjvwa1ot 53 5 is be VBZ cord-018437-yjvwa1ot 53 6 referred refer VBN cord-018437-yjvwa1ot 53 7 to to IN cord-018437-yjvwa1ot 53 8 as as IN cord-018437-yjvwa1ot 53 9 a a DT cord-018437-yjvwa1ot 53 10 virion virion NN cord-018437-yjvwa1ot 53 11 . . . cord-018437-yjvwa1ot 54 1 Icosahedral Icosahedral NNP cord-018437-yjvwa1ot 54 2 capsids capsid NNS cord-018437-yjvwa1ot 54 3 are be VBP cord-018437-yjvwa1ot 54 4 very very RB cord-018437-yjvwa1ot 54 5 common common JJ cord-018437-yjvwa1ot 54 6 ; ; : cord-018437-yjvwa1ot 54 7 these these DT cord-018437-yjvwa1ot 54 8 quasi quasi JJ cord-018437-yjvwa1ot 54 9 - - JJ cord-018437-yjvwa1ot 54 10 spherical spherical JJ cord-018437-yjvwa1ot 54 11 shells shell NNS cord-018437-yjvwa1ot 54 12 are be VBP cord-018437-yjvwa1ot 54 13 composed compose VBN cord-018437-yjvwa1ot 54 14 of of IN cord-018437-yjvwa1ot 54 15 20 20 CD cord-018437-yjvwa1ot 54 16 identical identical JJ cord-018437-yjvwa1ot 54 17 equilateral equilateral JJ cord-018437-yjvwa1ot 54 18 triangles triangle NNS cord-018437-yjvwa1ot 54 19 with with IN cord-018437-yjvwa1ot 54 20 30 30 CD cord-018437-yjvwa1ot 54 21 edges edge NNS cord-018437-yjvwa1ot 54 22 and and CC cord-018437-yjvwa1ot 54 23 12 12 CD cord-018437-yjvwa1ot 54 24 vertices vertex NNS cord-018437-yjvwa1ot 54 25 . . . cord-018437-yjvwa1ot 55 1 Icosahedral Icosahedral NNP cord-018437-yjvwa1ot 55 2 capsids capsid NNS cord-018437-yjvwa1ot 55 3 are be VBP cord-018437-yjvwa1ot 55 4 very very RB cord-018437-yjvwa1ot 55 5 effi effi NNP cord-018437-yjvwa1ot 55 6 cient cient NNP cord-018437-yjvwa1ot 55 7 geometrically geometrically RB cord-018437-yjvwa1ot 55 8 ( ( -LRB- cord-018437-yjvwa1ot 55 9 internal internal JJ cord-018437-yjvwa1ot 55 10 volume volume NN cord-018437-yjvwa1ot 55 11 versus versus IN cord-018437-yjvwa1ot 55 12 protein protein NN cord-018437-yjvwa1ot 55 13 content content NN cord-018437-yjvwa1ot 55 14 ) ) -RRB- cord-018437-yjvwa1ot 55 15 and and CC cord-018437-yjvwa1ot 55 16 genetically genetically RB cord-018437-yjvwa1ot 55 17 ( ( -LRB- cord-018437-yjvwa1ot 55 18 many many JJ cord-018437-yjvwa1ot 55 19 small small JJ cord-018437-yjvwa1ot 55 20 sides side NNS cord-018437-yjvwa1ot 55 21 require require VBP cord-018437-yjvwa1ot 55 22 fewer few JJR cord-018437-yjvwa1ot 55 23 and and CC cord-018437-yjvwa1ot 55 24 smaller small JJR cord-018437-yjvwa1ot 55 25 genes gene NNS cord-018437-yjvwa1ot 55 26 to to TO cord-018437-yjvwa1ot 55 27 code code VB cord-018437-yjvwa1ot 55 28 for for IN cord-018437-yjvwa1ot 55 29 capsid capsid NN cord-018437-yjvwa1ot 55 30 proteins protein NNS cord-018437-yjvwa1ot 55 31 ) ) -RRB- cord-018437-yjvwa1ot 55 32 . . . cord-018437-yjvwa1ot 56 1 The the DT cord-018437-yjvwa1ot 56 2 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 56 3 proteins protein NNS cord-018437-yjvwa1ot 56 4 of of IN cord-018437-yjvwa1ot 56 5 some some DT cord-018437-yjvwa1ot 56 6 viruses virus NNS cord-018437-yjvwa1ot 56 7 , , , cord-018437-yjvwa1ot 56 8 like like IN cord-018437-yjvwa1ot 56 9 the the DT cord-018437-yjvwa1ot 56 10 infl infl NN cord-018437-yjvwa1ot 56 11 uenza uenza NN cord-018437-yjvwa1ot 56 12 viruses virus NNS cord-018437-yjvwa1ot 56 13 , , , cord-018437-yjvwa1ot 56 14 form form VB cord-018437-yjvwa1ot 56 15 helical helical JJ cord-018437-yjvwa1ot 56 16 tubes tube NNS cord-018437-yjvwa1ot 56 17 with with IN cord-018437-yjvwa1ot 56 18 the the DT cord-018437-yjvwa1ot 56 19 nucleic nucleic JJ cord-018437-yjvwa1ot 56 20 acid acid NN cord-018437-yjvwa1ot 56 21 incorporated incorporate VBN cord-018437-yjvwa1ot 56 22 directly directly RB cord-018437-yjvwa1ot 56 23 into into IN cord-018437-yjvwa1ot 56 24 the the DT cord-018437-yjvwa1ot 56 25 helical helical JJ cord-018437-yjvwa1ot 56 26 structure structure NN cord-018437-yjvwa1ot 56 27 . . . cord-018437-yjvwa1ot 57 1 The the DT cord-018437-yjvwa1ot 57 2 nucleocapsids nucleocapsid NNS cord-018437-yjvwa1ot 57 3 of of IN cord-018437-yjvwa1ot 57 4 some some DT cord-018437-yjvwa1ot 57 5 viruses virus NNS cord-018437-yjvwa1ot 57 6 are be VBP cord-018437-yjvwa1ot 57 7 surrounded surround VBN cord-018437-yjvwa1ot 57 8 by by IN cord-018437-yjvwa1ot 57 9 envelopes envelope NNS cord-018437-yjvwa1ot 57 10 composed compose VBN cord-018437-yjvwa1ot 57 11 of of IN cord-018437-yjvwa1ot 57 12 lipid lipid NN cord-018437-yjvwa1ot 57 13 bilayers bilayer NNS cord-018437-yjvwa1ot 57 14 and and CC cord-018437-yjvwa1ot 57 15 host host NN cord-018437-yjvwa1ot 57 16 - - : cord-018437-yjvwa1ot 57 17 or or CC cord-018437-yjvwa1ot 57 18 viral viral RB cord-018437-yjvwa1ot 57 19 - - HYPH cord-018437-yjvwa1ot 57 20 encoded encode VBN cord-018437-yjvwa1ot 57 21 proteins protein NNS cord-018437-yjvwa1ot 57 22 . . . cord-018437-yjvwa1ot 58 1 Envelopes envelope NNS cord-018437-yjvwa1ot 58 2 are be VBP cord-018437-yjvwa1ot 58 3 typically typically RB cord-018437-yjvwa1ot 58 4 acquired acquire VBN cord-018437-yjvwa1ot 58 5 by by IN cord-018437-yjvwa1ot 58 6 budding bud VBG cord-018437-yjvwa1ot 58 7 of of IN cord-018437-yjvwa1ot 58 8 the the DT cord-018437-yjvwa1ot 58 9 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 58 10 through through IN cord-018437-yjvwa1ot 58 11 a a DT cord-018437-yjvwa1ot 58 12 virally virally RB cord-018437-yjvwa1ot 58 13 modifi modifi JJ cord-018437-yjvwa1ot 58 14 ed ed NN cord-018437-yjvwa1ot 58 15 portion portion NN cord-018437-yjvwa1ot 58 16 of of IN cord-018437-yjvwa1ot 58 17 a a DT cord-018437-yjvwa1ot 58 18 specifi specifi NN cord-018437-yjvwa1ot 58 19 c c NN cord-018437-yjvwa1ot 58 20 host host NN cord-018437-yjvwa1ot 58 21 - - HYPH cord-018437-yjvwa1ot 58 22 cell cell NN cord-018437-yjvwa1ot 58 23 membrane membrane NN cord-018437-yjvwa1ot 58 24 ( ( -LRB- cord-018437-yjvwa1ot 58 25 plasma plasma NN cord-018437-yjvwa1ot 58 26 , , , cord-018437-yjvwa1ot 58 27 endoplasmic endoplasmic NN cord-018437-yjvwa1ot 58 28 reticulum reticulum NN cord-018437-yjvwa1ot 58 29 , , , cord-018437-yjvwa1ot 58 30 Golgi Golgi NNP cord-018437-yjvwa1ot 58 31 , , , cord-018437-yjvwa1ot 58 32 nucleus nucleus NN cord-018437-yjvwa1ot 58 33 ) ) -RRB- cord-018437-yjvwa1ot 58 34 . . . cord-018437-yjvwa1ot 59 1 The the DT cord-018437-yjvwa1ot 59 2 shape shape NN cord-018437-yjvwa1ot 59 3 of of IN cord-018437-yjvwa1ot 59 4 the the DT cord-018437-yjvwa1ot 59 5 virus virus NN cord-018437-yjvwa1ot 59 6 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 59 7 or or CC cord-018437-yjvwa1ot 59 8 intact intact JJ cord-018437-yjvwa1ot 59 9 virion virion NN cord-018437-yjvwa1ot 59 10 is be VBZ cord-018437-yjvwa1ot 59 11 usually usually RB cord-018437-yjvwa1ot 59 12 determined determine VBN cord-018437-yjvwa1ot 59 13 by by IN cord-018437-yjvwa1ot 59 14 electron electron NN cord-018437-yjvwa1ot 59 15 microscopy microscopy NN cord-018437-yjvwa1ot 59 16 . . . cord-018437-yjvwa1ot 60 1 The the DT cord-018437-yjvwa1ot 60 2 shape shape NN cord-018437-yjvwa1ot 60 3 and and CC cord-018437-yjvwa1ot 60 4 dimensions dimension NNS cord-018437-yjvwa1ot 60 5 of of IN cord-018437-yjvwa1ot 60 6 the the DT cord-018437-yjvwa1ot 60 7 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 60 8 and and CC cord-018437-yjvwa1ot 60 9 intact intact JJ cord-018437-yjvwa1ot 60 10 virion virion NN cord-018437-yjvwa1ot 60 11 , , , cord-018437-yjvwa1ot 60 12 and and CC cord-018437-yjvwa1ot 60 13 the the DT cord-018437-yjvwa1ot 60 14 presence presence NN cord-018437-yjvwa1ot 60 15 or or CC cord-018437-yjvwa1ot 60 16 absence absence NN cord-018437-yjvwa1ot 60 17 of of IN cord-018437-yjvwa1ot 60 18 an an DT cord-018437-yjvwa1ot 60 19 envelope envelope NN cord-018437-yjvwa1ot 60 20 , , , cord-018437-yjvwa1ot 60 21 are be VBP cord-018437-yjvwa1ot 60 22 useful useful JJ cord-018437-yjvwa1ot 60 23 characteristics characteristic NNS cord-018437-yjvwa1ot 60 24 for for IN cord-018437-yjvwa1ot 60 25 classifying classify VBG cord-018437-yjvwa1ot 60 26 viruses virus NNS cord-018437-yjvwa1ot 60 27 . . . cord-018437-yjvwa1ot 61 1 • • NNP cord-018437-yjvwa1ot 62 1 Genome genome NN cord-018437-yjvwa1ot 62 2 : : : cord-018437-yjvwa1ot 63 1 The the DT cord-018437-yjvwa1ot 63 2 viral viral JJ cord-018437-yjvwa1ot 63 3 genome genome NN cord-018437-yjvwa1ot 63 4 is be VBZ cord-018437-yjvwa1ot 63 5 either either CC cord-018437-yjvwa1ot 63 6 DNA DNA NNP cord-018437-yjvwa1ot 63 7 or or CC cord-018437-yjvwa1ot 63 8 RNA RNA NNP cord-018437-yjvwa1ot 63 9 ; ; : cord-018437-yjvwa1ot 63 10 the the DT cord-018437-yjvwa1ot 63 11 nucleic nucleic JJ cord-018437-yjvwa1ot 63 12 acids acid NNS cord-018437-yjvwa1ot 63 13 may may MD cord-018437-yjvwa1ot 63 14 be be VB cord-018437-yjvwa1ot 63 15 single single JJ cord-018437-yjvwa1ot 63 16 or or CC cord-018437-yjvwa1ot 63 17 double double JJ cord-018437-yjvwa1ot 63 18 stranded strand VBN cord-018437-yjvwa1ot 63 19 . . . cord-018437-yjvwa1ot 64 1 The the DT cord-018437-yjvwa1ot 64 2 genome genome NN cord-018437-yjvwa1ot 64 3 size size NN cord-018437-yjvwa1ot 64 4 may may MD cord-018437-yjvwa1ot 64 5 be be VB cord-018437-yjvwa1ot 64 6 expressed express VBN cord-018437-yjvwa1ot 64 7 in in IN cord-018437-yjvwa1ot 64 8 terms term NNS cord-018437-yjvwa1ot 64 9 of of IN cord-018437-yjvwa1ot 64 10 kilobases kilobases NNP cord-018437-yjvwa1ot 64 11 ( ( -LRB- cord-018437-yjvwa1ot 64 12 kb kb NNP cord-018437-yjvwa1ot 64 13 ) ) -RRB- cord-018437-yjvwa1ot 64 14 for for IN cord-018437-yjvwa1ot 64 15 singlestranded singlestranded JJ cord-018437-yjvwa1ot 64 16 genomes genome NNS cord-018437-yjvwa1ot 64 17 or or CC cord-018437-yjvwa1ot 64 18 kilobase kilobase NN cord-018437-yjvwa1ot 64 19 pairs pair NNS cord-018437-yjvwa1ot 64 20 ( ( -LRB- cord-018437-yjvwa1ot 64 21 kbp kbp NNP cord-018437-yjvwa1ot 64 22 ) ) -RRB- cord-018437-yjvwa1ot 64 23 for for IN cord-018437-yjvwa1ot 64 24 double double RB cord-018437-yjvwa1ot 64 25 - - HYPH cord-018437-yjvwa1ot 64 26 stranded strand VBN cord-018437-yjvwa1ot 64 27 genomes genome NNS cord-018437-yjvwa1ot 64 28 . . . cord-018437-yjvwa1ot 65 1 The the DT cord-018437-yjvwa1ot 65 2 sequence sequence NN cord-018437-yjvwa1ot 65 3 of of IN cord-018437-yjvwa1ot 65 4 genes gene NNS cord-018437-yjvwa1ot 65 5 of of IN cord-018437-yjvwa1ot 65 6 positive positive JJ cord-018437-yjvwa1ot 65 7 - - HYPH cord-018437-yjvwa1ot 65 8 sense sense NN cord-018437-yjvwa1ot 65 9 ssRNA ssrna NN cord-018437-yjvwa1ot 65 10 may may MD cord-018437-yjvwa1ot 65 11 be be VB cord-018437-yjvwa1ot 65 12 directly directly RB cord-018437-yjvwa1ot 65 13 translated translate VBN cord-018437-yjvwa1ot 65 14 by by IN cord-018437-yjvwa1ot 65 15 the the DT cord-018437-yjvwa1ot 65 16 host host NN cord-018437-yjvwa1ot 65 17 into into IN cord-018437-yjvwa1ot 65 18 viral viral JJ cord-018437-yjvwa1ot 65 19 proteins protein NNS cord-018437-yjvwa1ot 65 20 . . . cord-018437-yjvwa1ot 66 1 The the DT cord-018437-yjvwa1ot 66 2 sequence sequence NN cord-018437-yjvwa1ot 66 3 of of IN cord-018437-yjvwa1ot 66 4 negative negative JJ cord-018437-yjvwa1ot 66 5 - - HYPH cord-018437-yjvwa1ot 66 6 sense sense NN cord-018437-yjvwa1ot 66 7 ssRNA ssrna NN cord-018437-yjvwa1ot 66 8 is be VBZ cord-018437-yjvwa1ot 66 9 complementary complementary JJ cord-018437-yjvwa1ot 66 10 to to IN cord-018437-yjvwa1ot 66 11 the the DT cord-018437-yjvwa1ot 66 12 coding code VBG cord-018437-yjvwa1ot 66 13 sequence sequence NN cord-018437-yjvwa1ot 66 14 for for IN cord-018437-yjvwa1ot 66 15 translation translation NN cord-018437-yjvwa1ot 66 16 , , , cord-018437-yjvwa1ot 66 17 so so IN cord-018437-yjvwa1ot 66 18 mRNA mRNA NNP cord-018437-yjvwa1ot 66 19 must must MD cord-018437-yjvwa1ot 66 20 be be VB cord-018437-yjvwa1ot 66 21 synthesized synthesize VBN cord-018437-yjvwa1ot 66 22 by by IN cord-018437-yjvwa1ot 66 23 RNA RNA NNP cord-018437-yjvwa1ot 66 24 polymerase polymerase NN cord-018437-yjvwa1ot 66 25 , , , cord-018437-yjvwa1ot 66 26 typically typically RB cord-018437-yjvwa1ot 66 27 carried carry VBN cord-018437-yjvwa1ot 66 28 within within IN cord-018437-yjvwa1ot 66 29 the the DT cord-018437-yjvwa1ot 66 30 virion virion NN cord-018437-yjvwa1ot 66 31 , , , cord-018437-yjvwa1ot 66 32 before before IN cord-018437-yjvwa1ot 66 33 translation translation NN cord-018437-yjvwa1ot 66 34 into into IN cord-018437-yjvwa1ot 66 35 viral viral JJ cord-018437-yjvwa1ot 66 36 proteins protein NNS cord-018437-yjvwa1ot 66 37 . . . cord-018437-yjvwa1ot 67 1 The the DT cord-018437-yjvwa1ot 67 2 sequence sequence NN cord-018437-yjvwa1ot 67 3 of of IN cord-018437-yjvwa1ot 67 4 positive positive JJ cord-018437-yjvwa1ot 67 5 - - HYPH cord-018437-yjvwa1ot 67 6 sense sense NN cord-018437-yjvwa1ot 67 7 ssDNA ssdna NN cord-018437-yjvwa1ot 67 8 is be VBZ cord-018437-yjvwa1ot 67 9 the the DT cord-018437-yjvwa1ot 67 10 same same JJ cord-018437-yjvwa1ot 67 11 as as IN cord-018437-yjvwa1ot 67 12 that that DT cord-018437-yjvwa1ot 67 13 of of IN cord-018437-yjvwa1ot 67 14 the the DT cord-018437-yjvwa1ot 67 15 mRNA mrna NN cord-018437-yjvwa1ot 67 16 coding code VBG cord-018437-yjvwa1ot 67 17 for for IN cord-018437-yjvwa1ot 67 18 viral viral JJ cord-018437-yjvwa1ot 67 19 proteins protein NNS cord-018437-yjvwa1ot 67 20 ; ; : cord-018437-yjvwa1ot 67 21 negative negative JJ cord-018437-yjvwa1ot 67 22 - - HYPH cord-018437-yjvwa1ot 67 23 sense sense NN cord-018437-yjvwa1ot 67 24 ssDNA ssdna NN cord-018437-yjvwa1ot 67 25 is be VBZ cord-018437-yjvwa1ot 67 26 complementary complementary JJ cord-018437-yjvwa1ot 67 27 to to IN cord-018437-yjvwa1ot 67 28 mRNA mRNA NNP cord-018437-yjvwa1ot 67 29 and and CC cord-018437-yjvwa1ot 67 30 may may MD cord-018437-yjvwa1ot 67 31 be be VB cord-018437-yjvwa1ot 67 32 transcribed transcribe VBN cord-018437-yjvwa1ot 67 33 into into IN cord-018437-yjvwa1ot 67 34 mRNA mrna NN cord-018437-yjvwa1ot 67 35 for for IN cord-018437-yjvwa1ot 67 36 viral viral JJ cord-018437-yjvwa1ot 67 37 protein protein NN cord-018437-yjvwa1ot 67 38 synthesis synthesis NN cord-018437-yjvwa1ot 67 39 . . . cord-018437-yjvwa1ot 68 1 Ambisense ambisense VB cord-018437-yjvwa1ot 68 2 single single RB cord-018437-yjvwa1ot 68 3 - - HYPH cord-018437-yjvwa1ot 68 4 stranded strand VBN cord-018437-yjvwa1ot 68 5 nucleic nucleic JJ cord-018437-yjvwa1ot 68 6 acids acid NNS cord-018437-yjvwa1ot 68 7 use use VBP cord-018437-yjvwa1ot 68 8 both both DT cord-018437-yjvwa1ot 68 9 positive positive JJ cord-018437-yjvwa1ot 68 10 - - HYPH cord-018437-yjvwa1ot 68 11 sense sense NN cord-018437-yjvwa1ot 68 12 and and CC cord-018437-yjvwa1ot 68 13 negative negative JJ cord-018437-yjvwa1ot 68 14 - - HYPH cord-018437-yjvwa1ot 68 15 sense sense NN cord-018437-yjvwa1ot 68 16 sequences sequence NNS cord-018437-yjvwa1ot 68 17 . . . cord-018437-yjvwa1ot 69 1 The the DT cord-018437-yjvwa1ot 69 2 viral viral JJ cord-018437-yjvwa1ot 69 3 nucleic nucleic JJ cord-018437-yjvwa1ot 69 4 acid acid NN cord-018437-yjvwa1ot 69 5 may may MD cord-018437-yjvwa1ot 69 6 be be VB cord-018437-yjvwa1ot 69 7 linear linear JJ cord-018437-yjvwa1ot 69 8 or or CC cord-018437-yjvwa1ot 69 9 circular circular JJ cord-018437-yjvwa1ot 69 10 ; ; : cord-018437-yjvwa1ot 69 11 the the DT cord-018437-yjvwa1ot 69 12 nucleic nucleic JJ cord-018437-yjvwa1ot 69 13 acid acid NN cord-018437-yjvwa1ot 69 14 may may MD cord-018437-yjvwa1ot 69 15 be be VB cord-018437-yjvwa1ot 69 16 in in IN cord-018437-yjvwa1ot 69 17 the the DT cord-018437-yjvwa1ot 69 18 form form NN cord-018437-yjvwa1ot 69 19 of of IN cord-018437-yjvwa1ot 69 20 a a DT cord-018437-yjvwa1ot 69 21 single single JJ cord-018437-yjvwa1ot 69 22 molecule molecule NN cord-018437-yjvwa1ot 69 23 or or CC cord-018437-yjvwa1ot 69 24 broken break VBN cord-018437-yjvwa1ot 69 25 into into IN cord-018437-yjvwa1ot 69 26 two two CD cord-018437-yjvwa1ot 69 27 or or CC cord-018437-yjvwa1ot 69 28 more more JJR cord-018437-yjvwa1ot 69 29 segments segment NNS cord-018437-yjvwa1ot 69 30 . . . cord-018437-yjvwa1ot 70 1 In in IN cord-018437-yjvwa1ot 70 2 addition addition NN cord-018437-yjvwa1ot 70 3 to to IN cord-018437-yjvwa1ot 70 4 the the DT cord-018437-yjvwa1ot 70 5 type type NN cord-018437-yjvwa1ot 70 6 of of IN cord-018437-yjvwa1ot 70 7 nucleic nucleic JJ cord-018437-yjvwa1ot 70 8 acid acid NN cord-018437-yjvwa1ot 70 9 , , , cord-018437-yjvwa1ot 70 10 the the DT cord-018437-yjvwa1ot 70 11 size size NN cord-018437-yjvwa1ot 70 12 of of IN cord-018437-yjvwa1ot 70 13 the the DT cord-018437-yjvwa1ot 70 14 viral viral JJ cord-018437-yjvwa1ot 70 15 genome genome NN cord-018437-yjvwa1ot 70 16 , , , cord-018437-yjvwa1ot 70 17 measured measure VBN cord-018437-yjvwa1ot 70 18 in in IN cord-018437-yjvwa1ot 70 19 number number NN cord-018437-yjvwa1ot 70 20 of of IN cord-018437-yjvwa1ot 70 21 bases basis NNS cord-018437-yjvwa1ot 70 22 or or CC cord-018437-yjvwa1ot 70 23 base base NN cord-018437-yjvwa1ot 70 24 pairs pair NNS cord-018437-yjvwa1ot 70 25 , , , cord-018437-yjvwa1ot 70 26 is be VBZ cord-018437-yjvwa1ot 70 27 an an DT cord-018437-yjvwa1ot 70 28 important important JJ cord-018437-yjvwa1ot 70 29 characteristic characteristic NN cord-018437-yjvwa1ot 70 30 used use VBN cord-018437-yjvwa1ot 70 31 for for IN cord-018437-yjvwa1ot 70 32 classifi classifi NNP cord-018437-yjvwa1ot 70 33 cation cation NNP cord-018437-yjvwa1ot 70 34 . . . cord-018437-yjvwa1ot 71 1 • • NNP cord-018437-yjvwa1ot 72 1 Nucleic Nucleic NNP cord-018437-yjvwa1ot 72 2 Acid Acid NNP cord-018437-yjvwa1ot 72 3 Sequence sequence NN cord-018437-yjvwa1ot 72 4 Analysis Analysis NNP cord-018437-yjvwa1ot 72 5 : : : cord-018437-yjvwa1ot 72 6 The the DT cord-018437-yjvwa1ot 72 7 analysis analysis NN cord-018437-yjvwa1ot 72 8 of of IN cord-018437-yjvwa1ot 72 9 specifi specifi NNP cord-018437-yjvwa1ot 72 10 c c NN cord-018437-yjvwa1ot 72 11 viral viral JJ cord-018437-yjvwa1ot 72 12 nucleic nucleic JJ cord-018437-yjvwa1ot 72 13 acid acid NN cord-018437-yjvwa1ot 72 14 sequences sequence NNS cord-018437-yjvwa1ot 72 15 is be VBZ cord-018437-yjvwa1ot 72 16 increasingly increasingly RB cord-018437-yjvwa1ot 72 17 used use VBN cord-018437-yjvwa1ot 72 18 as as IN cord-018437-yjvwa1ot 72 19 a a DT cord-018437-yjvwa1ot 72 20 powerful powerful JJ cord-018437-yjvwa1ot 72 21 tool tool NN cord-018437-yjvwa1ot 72 22 for for IN cord-018437-yjvwa1ot 72 23 taxonomic taxonomic JJ cord-018437-yjvwa1ot 72 24 assignment assignment NN cord-018437-yjvwa1ot 72 25 and and CC cord-018437-yjvwa1ot 72 26 assessment assessment NN cord-018437-yjvwa1ot 72 27 of of IN cord-018437-yjvwa1ot 72 28 evolutionary evolutionary JJ cord-018437-yjvwa1ot 72 29 relatedness relatedness NN cord-018437-yjvwa1ot 72 30 . . . cord-018437-yjvwa1ot 73 1 The the DT cord-018437-yjvwa1ot 73 2 utility utility NN cord-018437-yjvwa1ot 73 3 is be VBZ cord-018437-yjvwa1ot 73 4 greatest great JJS cord-018437-yjvwa1ot 73 5 for for IN cord-018437-yjvwa1ot 73 6 related related JJ cord-018437-yjvwa1ot 73 7 groups group NNS cord-018437-yjvwa1ot 73 8 of of IN cord-018437-yjvwa1ot 73 9 viruses virus NNS cord-018437-yjvwa1ot 73 10 ( ( -LRB- cord-018437-yjvwa1ot 73 11 Lauber Lauber NNP cord-018437-yjvwa1ot 73 12 and and CC cord-018437-yjvwa1ot 73 13 Gorbalenya Gorbalenya NNP cord-018437-yjvwa1ot 73 14 2012a 2012a NNS cord-018437-yjvwa1ot 73 15 , , , cord-018437-yjvwa1ot 73 16 b b LS cord-018437-yjvwa1ot 73 17 ) ) -RRB- cord-018437-yjvwa1ot 73 18 , , , cord-018437-yjvwa1ot 73 19 but but CC cord-018437-yjvwa1ot 73 20 has have VBZ cord-018437-yjvwa1ot 73 21 been be VBN cord-018437-yjvwa1ot 73 22 challenging challenge VBG cord-018437-yjvwa1ot 73 23 for for IN cord-018437-yjvwa1ot 73 24 more more RBR cord-018437-yjvwa1ot 73 25 divergent divergent JJ cord-018437-yjvwa1ot 73 26 groups group NNS cord-018437-yjvwa1ot 73 27 of of IN cord-018437-yjvwa1ot 73 28 viruses virus NNS cord-018437-yjvwa1ot 73 29 . . . cord-018437-yjvwa1ot 74 1 Sequence sequence NN cord-018437-yjvwa1ot 74 2 analysis analysis NN cord-018437-yjvwa1ot 74 3 alone alone RB cord-018437-yjvwa1ot 74 4 has have VBZ cord-018437-yjvwa1ot 74 5 not not RB cord-018437-yjvwa1ot 74 6 provided provide VBN cord-018437-yjvwa1ot 74 7 a a DT cord-018437-yjvwa1ot 74 8 reliable reliable JJ cord-018437-yjvwa1ot 74 9 single single JJ cord-018437-yjvwa1ot 74 10 criterion criterion NN cord-018437-yjvwa1ot 74 11 on on IN cord-018437-yjvwa1ot 74 12 which which WDT cord-018437-yjvwa1ot 74 13 all all DT cord-018437-yjvwa1ot 74 14 viruses virus NNS cord-018437-yjvwa1ot 74 15 may may MD cord-018437-yjvwa1ot 74 16 be be VB cord-018437-yjvwa1ot 74 17 classifi classifi NNP cord-018437-yjvwa1ot 74 18 ed ed NNP cord-018437-yjvwa1ot 74 19 . . . cord-018437-yjvwa1ot 75 1 Construction construction NN cord-018437-yjvwa1ot 75 2 of of IN cord-018437-yjvwa1ot 75 3 a a DT cord-018437-yjvwa1ot 75 4 universal universal JJ cord-018437-yjvwa1ot 75 5 phylogenetic phylogenetic JJ cord-018437-yjvwa1ot 75 6 tree tree NN cord-018437-yjvwa1ot 75 7 for for IN cord-018437-yjvwa1ot 75 8 viruses virus NNS cord-018437-yjvwa1ot 75 9 , , , cord-018437-yjvwa1ot 75 10 as as IN cord-018437-yjvwa1ot 75 11 has have VBZ cord-018437-yjvwa1ot 75 12 been be VBN cord-018437-yjvwa1ot 75 13 proposed propose VBN cord-018437-yjvwa1ot 75 14 for for IN cord-018437-yjvwa1ot 75 15 cellular cellular JJ cord-018437-yjvwa1ot 75 16 life life NN cord-018437-yjvwa1ot 75 17 - - HYPH cord-018437-yjvwa1ot 75 18 forms form NNS cord-018437-yjvwa1ot 75 19 , , , cord-018437-yjvwa1ot 75 20 may may MD cord-018437-yjvwa1ot 75 21 not not RB cord-018437-yjvwa1ot 75 22 be be VB cord-018437-yjvwa1ot 75 23 possible possible JJ cord-018437-yjvwa1ot 75 24 for for IN cord-018437-yjvwa1ot 75 25 viruses virus NNS cord-018437-yjvwa1ot 75 26 . . . cord-018437-yjvwa1ot 76 1 It -PRON- PRP cord-018437-yjvwa1ot 76 2 is be VBZ cord-018437-yjvwa1ot 76 3 not not RB cord-018437-yjvwa1ot 76 4 clear clear JJ cord-018437-yjvwa1ot 76 5 that that IN cord-018437-yjvwa1ot 76 6 all all DT cord-018437-yjvwa1ot 76 7 viruses virus NNS cord-018437-yjvwa1ot 76 8 emerged emerge VBD cord-018437-yjvwa1ot 76 9 from from IN cord-018437-yjvwa1ot 76 10 a a DT cord-018437-yjvwa1ot 76 11 single single JJ cord-018437-yjvwa1ot 76 12 progenitor progenitor NN cord-018437-yjvwa1ot 76 13 virus virus NN cord-018437-yjvwa1ot 76 14 ; ; : cord-018437-yjvwa1ot 76 15 there there EX cord-018437-yjvwa1ot 76 16 is be VBZ cord-018437-yjvwa1ot 76 17 evidence evidence NN cord-018437-yjvwa1ot 76 18 for for IN cord-018437-yjvwa1ot 76 19 multiple multiple JJ cord-018437-yjvwa1ot 76 20 , , , cord-018437-yjvwa1ot 76 21 independent independent JJ cord-018437-yjvwa1ot 76 22 origins origin NNS cord-018437-yjvwa1ot 76 23 of of IN cord-018437-yjvwa1ot 76 24 existing exist VBG cord-018437-yjvwa1ot 76 25 viruses virus NNS cord-018437-yjvwa1ot 76 26 . . . cord-018437-yjvwa1ot 77 1 Phylogenetic phylogenetic JJ cord-018437-yjvwa1ot 77 2 analysis analysis NN cord-018437-yjvwa1ot 77 3 using use VBG cord-018437-yjvwa1ot 77 4 nucleic nucleic JJ cord-018437-yjvwa1ot 77 5 acid acid NN cord-018437-yjvwa1ot 77 6 sequences sequence NNS cord-018437-yjvwa1ot 77 7 is be VBZ cord-018437-yjvwa1ot 77 8 further far RBR cord-018437-yjvwa1ot 77 9 complicated complicate VBN cord-018437-yjvwa1ot 77 10 by by IN cord-018437-yjvwa1ot 77 11 recombination recombination NN cord-018437-yjvwa1ot 77 12 , , , cord-018437-yjvwa1ot 77 13 reassortment reassortment NN cord-018437-yjvwa1ot 77 14 , , , cord-018437-yjvwa1ot 77 15 incorporation incorporation NN cord-018437-yjvwa1ot 77 16 of of IN cord-018437-yjvwa1ot 77 17 host host NN cord-018437-yjvwa1ot 77 18 nucleic nucleic JJ cord-018437-yjvwa1ot 77 19 acid acid NN cord-018437-yjvwa1ot 77 20 sequences sequence NNS cord-018437-yjvwa1ot 77 21 , , , cord-018437-yjvwa1ot 77 22 and and CC cord-018437-yjvwa1ot 77 23 other other JJ cord-018437-yjvwa1ot 77 24 factors factor NNS cord-018437-yjvwa1ot 77 25 ( ( -LRB- cord-018437-yjvwa1ot 77 26 Domingo Domingo NNP cord-018437-yjvwa1ot 77 27 2007 2007 CD cord-018437-yjvwa1ot 77 28 ; ; : cord-018437-yjvwa1ot 77 29 Holmes Holmes NNP cord-018437-yjvwa1ot 77 30 2011 2011 CD cord-018437-yjvwa1ot 77 31 ) ) -RRB- cord-018437-yjvwa1ot 77 32 . . . cord-018437-yjvwa1ot 78 1 Currently currently RB cord-018437-yjvwa1ot 78 2 , , , cord-018437-yjvwa1ot 78 3 expert expert JJ cord-018437-yjvwa1ot 78 4 consensus consensus NN cord-018437-yjvwa1ot 78 5 , , , cord-018437-yjvwa1ot 78 6 considering consider VBG cord-018437-yjvwa1ot 78 7 laboratory laboratory NN cord-018437-yjvwa1ot 78 8 , , , cord-018437-yjvwa1ot 78 9 phenotypic phenotypic JJ cord-018437-yjvwa1ot 78 10 , , , cord-018437-yjvwa1ot 78 11 clinical clinical JJ cord-018437-yjvwa1ot 78 12 , , , cord-018437-yjvwa1ot 78 13 and and CC cord-018437-yjvwa1ot 78 14 other other JJ cord-018437-yjvwa1ot 78 15 characteristics characteristic NNS cord-018437-yjvwa1ot 78 16 , , , cord-018437-yjvwa1ot 78 17 remains remain VBZ cord-018437-yjvwa1ot 78 18 the the DT cord-018437-yjvwa1ot 78 19 most most RBS cord-018437-yjvwa1ot 78 20 accurate accurate JJ cord-018437-yjvwa1ot 78 21 and and CC cord-018437-yjvwa1ot 78 22 robust robust JJ cord-018437-yjvwa1ot 78 23 method method NN cord-018437-yjvwa1ot 78 24 for for IN cord-018437-yjvwa1ot 78 25 the the DT cord-018437-yjvwa1ot 78 26 classifi classifi NNP cord-018437-yjvwa1ot 78 27 cation cation NNP cord-018437-yjvwa1ot 78 28 and and CC cord-018437-yjvwa1ot 78 29 taxonomic taxonomic JJ cord-018437-yjvwa1ot 78 30 assignment assignment NN cord-018437-yjvwa1ot 78 31 of of IN cord-018437-yjvwa1ot 78 32 viruses virus NNS cord-018437-yjvwa1ot 78 33 . . . cord-018437-yjvwa1ot 79 1 Note note VB cord-018437-yjvwa1ot 79 2 that that IN cord-018437-yjvwa1ot 79 3 the the DT cord-018437-yjvwa1ot 79 4 formal formal JJ cord-018437-yjvwa1ot 79 5 names name NNS cord-018437-yjvwa1ot 79 6 assigned assign VBN cord-018437-yjvwa1ot 79 7 at at IN cord-018437-yjvwa1ot 79 8 all all DT cord-018437-yjvwa1ot 79 9 taxonomic taxonomic JJ cord-018437-yjvwa1ot 79 10 levels level NNS cord-018437-yjvwa1ot 79 11 are be VBP cord-018437-yjvwa1ot 79 12 italicized italicize VBN cord-018437-yjvwa1ot 79 13 , , , cord-018437-yjvwa1ot 79 14 while while IN cord-018437-yjvwa1ot 79 15 the the DT cord-018437-yjvwa1ot 79 16 common common JJ cord-018437-yjvwa1ot 79 17 names name NNS cord-018437-yjvwa1ot 79 18 , , , cord-018437-yjvwa1ot 79 19 which which WDT cord-018437-yjvwa1ot 79 20 are be VBP cord-018437-yjvwa1ot 79 21 often often RB cord-018437-yjvwa1ot 79 22 used use VBN cord-018437-yjvwa1ot 79 23 clinically clinically RB cord-018437-yjvwa1ot 79 24 , , , cord-018437-yjvwa1ot 79 25 are be VBP cord-018437-yjvwa1ot 79 26 not not RB cord-018437-yjvwa1ot 79 27 italicized italicize VBN cord-018437-yjvwa1ot 79 28 . . . cord-018437-yjvwa1ot 80 1 The the DT cord-018437-yjvwa1ot 80 2 viruses virus NNS cord-018437-yjvwa1ot 80 3 that that WDT cord-018437-yjvwa1ot 80 4 have have VBP cord-018437-yjvwa1ot 80 5 been be VBN cord-018437-yjvwa1ot 80 6 associated associate VBN cord-018437-yjvwa1ot 80 7 with with IN cord-018437-yjvwa1ot 80 8 human human JJ cord-018437-yjvwa1ot 80 9 infections infection NNS cord-018437-yjvwa1ot 80 10 are be VBP cord-018437-yjvwa1ot 80 11 shown show VBN cord-018437-yjvwa1ot 80 12 in in IN cord-018437-yjvwa1ot 80 13 Table Table NNP cord-018437-yjvwa1ot 80 14 3 3 CD cord-018437-yjvwa1ot 80 15 .1 .1 NFP cord-018437-yjvwa1ot 80 16 . . . cord-018437-yjvwa1ot 81 1 Among among IN cord-018437-yjvwa1ot 81 2 the the DT cord-018437-yjvwa1ot 81 3 families family NNS cord-018437-yjvwa1ot 81 4 of of IN cord-018437-yjvwa1ot 81 5 viruses virus NNS cord-018437-yjvwa1ot 81 6 able able JJ cord-018437-yjvwa1ot 81 7 to to TO cord-018437-yjvwa1ot 81 8 infect infect VB cord-018437-yjvwa1ot 81 9 humans human NNS cord-018437-yjvwa1ot 81 10 and and CC cord-018437-yjvwa1ot 81 11 other other JJ cord-018437-yjvwa1ot 81 12 vertebrate vertebrate JJ cord-018437-yjvwa1ot 81 13 hosts host NNS cord-018437-yjvwa1ot 81 14 , , , cord-018437-yjvwa1ot 81 15 there there EX cord-018437-yjvwa1ot 81 16 are be VBP cord-018437-yjvwa1ot 81 17 many many JJ cord-018437-yjvwa1ot 81 18 species specie NNS cord-018437-yjvwa1ot 81 19 that that WDT cord-018437-yjvwa1ot 81 20 target target VBP cord-018437-yjvwa1ot 81 21 and and CC cord-018437-yjvwa1ot 81 22 cause cause VB cord-018437-yjvwa1ot 81 23 disease disease NN cord-018437-yjvwa1ot 81 24 in in IN cord-018437-yjvwa1ot 81 25 the the DT cord-018437-yjvwa1ot 81 26 lung lung NN cord-018437-yjvwa1ot 81 27 . . . cord-018437-yjvwa1ot 82 1 These these DT cord-018437-yjvwa1ot 82 2 viruses virus NNS cord-018437-yjvwa1ot 82 3 commonly commonly RB cord-018437-yjvwa1ot 82 4 use use VBP cord-018437-yjvwa1ot 82 5 airborne airborne JJ cord-018437-yjvwa1ot 82 6 transmission transmission NN cord-018437-yjvwa1ot 82 7 as as IN cord-018437-yjvwa1ot 82 8 an an DT cord-018437-yjvwa1ot 82 9 effective effective JJ cord-018437-yjvwa1ot 82 10 mode mode NN cord-018437-yjvwa1ot 82 11 of of IN cord-018437-yjvwa1ot 82 12 transmission transmission NN cord-018437-yjvwa1ot 82 13 between between IN cord-018437-yjvwa1ot 82 14 an an DT cord-018437-yjvwa1ot 82 15 infected infected JJ cord-018437-yjvwa1ot 82 16 host host NN cord-018437-yjvwa1ot 82 17 and and CC cord-018437-yjvwa1ot 82 18 a a DT cord-018437-yjvwa1ot 82 19 new new JJ cord-018437-yjvwa1ot 82 20 susceptible susceptible JJ cord-018437-yjvwa1ot 82 21 host host NN cord-018437-yjvwa1ot 82 22 . . . cord-018437-yjvwa1ot 83 1 Characteristics characteristic NNS cord-018437-yjvwa1ot 83 2 of of IN cord-018437-yjvwa1ot 83 3 viruses virus NNS cord-018437-yjvwa1ot 83 4 that that WDT cord-018437-yjvwa1ot 83 5 directly directly RB cord-018437-yjvwa1ot 83 6 or or CC cord-018437-yjvwa1ot 83 7 indirectly indirectly RB cord-018437-yjvwa1ot 83 8 cause cause VB cord-018437-yjvwa1ot 83 9 pulmonary pulmonary JJ cord-018437-yjvwa1ot 83 10 disease disease NN cord-018437-yjvwa1ot 83 11 are be VBP cord-018437-yjvwa1ot 83 12 discussed discuss VBN cord-018437-yjvwa1ot 83 13 in in IN cord-018437-yjvwa1ot 83 14 this this DT cord-018437-yjvwa1ot 83 15 section section NN cord-018437-yjvwa1ot 83 16 . . . cord-018437-yjvwa1ot 84 1 Adenoviridae Adenoviridae NNP cord-018437-yjvwa1ot 84 2 : : : cord-018437-yjvwa1ot 85 1 Adenoviruses adenovirus NNS cord-018437-yjvwa1ot 85 2 are be VBP cord-018437-yjvwa1ot 85 3 pathogenic pathogenic JJ cord-018437-yjvwa1ot 85 4 for for IN cord-018437-yjvwa1ot 85 5 humans human NNS cord-018437-yjvwa1ot 85 6 and and CC cord-018437-yjvwa1ot 85 7 other other JJ cord-018437-yjvwa1ot 85 8 vertebrate vertebrate JJ cord-018437-yjvwa1ot 85 9 species specie NNS cord-018437-yjvwa1ot 85 10 . . . cord-018437-yjvwa1ot 86 1 A a DT cord-018437-yjvwa1ot 86 2 structural structural JJ cord-018437-yjvwa1ot 86 3 protein protein NN cord-018437-yjvwa1ot 86 4 at at IN cord-018437-yjvwa1ot 86 5 each each DT cord-018437-yjvwa1ot 86 6 of of IN cord-018437-yjvwa1ot 86 7 the the DT cord-018437-yjvwa1ot 86 8 12 12 CD cord-018437-yjvwa1ot 86 9 of of IN cord-018437-yjvwa1ot 86 10 the the DT cord-018437-yjvwa1ot 86 11 icosahedral icosahedral JJ cord-018437-yjvwa1ot 86 12 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 86 13 vertices vertice VBZ cord-018437-yjvwa1ot 86 14 anchors anchor NNS cord-018437-yjvwa1ot 86 15 a a DT cord-018437-yjvwa1ot 86 16 rodlike rodlike JJ cord-018437-yjvwa1ot 86 17 projection projection NN cord-018437-yjvwa1ot 86 18 with with IN cord-018437-yjvwa1ot 86 19 a a DT cord-018437-yjvwa1ot 86 20 terminal terminal JJ cord-018437-yjvwa1ot 86 21 knob knob NN cord-018437-yjvwa1ot 86 22 , , , cord-018437-yjvwa1ot 86 23 which which WDT cord-018437-yjvwa1ot 86 24 interacts interact VBZ cord-018437-yjvwa1ot 86 25 with with IN cord-018437-yjvwa1ot 86 26 specifi specifi NNP cord-018437-yjvwa1ot 86 27 c c NNP cord-018437-yjvwa1ot 86 28 host host NN cord-018437-yjvwa1ot 86 29 surface surface NN cord-018437-yjvwa1ot 86 30 receptor receptor NN cord-018437-yjvwa1ot 86 31 molecules molecule NNS cord-018437-yjvwa1ot 86 32 and and CC cord-018437-yjvwa1ot 86 33 which which WDT cord-018437-yjvwa1ot 86 34 confers confer VBZ cord-018437-yjvwa1ot 86 35 the the DT cord-018437-yjvwa1ot 86 36 hemagglutination hemagglutination NN cord-018437-yjvwa1ot 86 37 pattern pattern NN cord-018437-yjvwa1ot 86 38 and and CC cord-018437-yjvwa1ot 86 39 tissue tissue NN cord-018437-yjvwa1ot 86 40 tropism tropism NN cord-018437-yjvwa1ot 86 41 for for IN cord-018437-yjvwa1ot 86 42 the the DT cord-018437-yjvwa1ot 86 43 different different JJ cord-018437-yjvwa1ot 86 44 groups group NNS cord-018437-yjvwa1ot 86 45 of of IN cord-018437-yjvwa1ot 86 46 adenoviruses adenovirus NNS cord-018437-yjvwa1ot 86 47 . . . cord-018437-yjvwa1ot 87 1 The the DT cord-018437-yjvwa1ot 87 2 genome genome NN cord-018437-yjvwa1ot 87 3 encodes encode VBZ cord-018437-yjvwa1ot 87 4 ~40 ~40 NNP cord-018437-yjvwa1ot 87 5 genes gene NNS cord-018437-yjvwa1ot 87 6 ( ( -LRB- cord-018437-yjvwa1ot 87 7 Davison Davison NNP cord-018437-yjvwa1ot 87 8 et et FW cord-018437-yjvwa1ot 87 9 al al NNP cord-018437-yjvwa1ot 87 10 . . NNP cord-018437-yjvwa1ot 87 11 2003a 2003a CD cord-018437-yjvwa1ot 87 12 ) ) -RRB- cord-018437-yjvwa1ot 87 13 , , , cord-018437-yjvwa1ot 87 14 including include VBG cord-018437-yjvwa1ot 87 15 common common JJ cord-018437-yjvwa1ot 87 16 genes gene NNS cord-018437-yjvwa1ot 87 17 and and CC cord-018437-yjvwa1ot 87 18 species species NN cord-018437-yjvwa1ot 87 19 - - HYPH cord-018437-yjvwa1ot 87 20 specifi specifi NN cord-018437-yjvwa1ot 87 21 c c NN cord-018437-yjvwa1ot 87 22 genes gene NNS cord-018437-yjvwa1ot 87 23 . . . cord-018437-yjvwa1ot 88 1 Genes gene NNS cord-018437-yjvwa1ot 88 2 are be VBP cord-018437-yjvwa1ot 88 3 grouped group VBN cord-018437-yjvwa1ot 88 4 into into IN cord-018437-yjvwa1ot 88 5 early early RB cord-018437-yjvwa1ot 88 6 , , , cord-018437-yjvwa1ot 88 7 delayed delay VBN cord-018437-yjvwa1ot 88 8 early early RB cord-018437-yjvwa1ot 88 9 , , , cord-018437-yjvwa1ot 88 10 and and CC cord-018437-yjvwa1ot 88 11 late late RB cord-018437-yjvwa1ot 88 12 transcribed transcribe VBN cord-018437-yjvwa1ot 88 13 genes gene NNS cord-018437-yjvwa1ot 88 14 . . . cord-018437-yjvwa1ot 89 1 The the DT cord-018437-yjvwa1ot 89 2 genome genome NN cord-018437-yjvwa1ot 89 3 contains contain VBZ cord-018437-yjvwa1ot 89 4 inverted inverted JJ cord-018437-yjvwa1ot 89 5 repeat repeat NN cord-018437-yjvwa1ot 89 6 sequences sequence NNS cord-018437-yjvwa1ot 89 7 at at IN cord-018437-yjvwa1ot 89 8 both both DT cord-018437-yjvwa1ot 89 9 ends end NNS cord-018437-yjvwa1ot 89 10 . . . cord-018437-yjvwa1ot 90 1 Sequences sequence NNS cord-018437-yjvwa1ot 90 2 of of IN cord-018437-yjvwa1ot 90 3 both both CC cord-018437-yjvwa1ot 90 4 DNA dna NN cord-018437-yjvwa1ot 90 5 strands strand NNS cord-018437-yjvwa1ot 90 6 are be VBP cord-018437-yjvwa1ot 90 7 transcribed transcribe VBN cord-018437-yjvwa1ot 90 8 to to IN cord-018437-yjvwa1ot 90 9 mRNA mRNA NNP cord-018437-yjvwa1ot 90 10 ; ; : cord-018437-yjvwa1ot 90 11 mRNA mrna NN cord-018437-yjvwa1ot 90 12 splicing splicing NN cord-018437-yjvwa1ot 90 13 is be VBZ cord-018437-yjvwa1ot 90 14 used use VBN cord-018437-yjvwa1ot 90 15 for for IN cord-018437-yjvwa1ot 90 16 expression expression NN cord-018437-yjvwa1ot 90 17 of of IN cord-018437-yjvwa1ot 90 18 many many JJ cord-018437-yjvwa1ot 90 19 adenovirus adenovirus NN cord-018437-yjvwa1ot 90 20 genes gene NNS cord-018437-yjvwa1ot 90 21 . . . cord-018437-yjvwa1ot 91 1 The the DT cord-018437-yjvwa1ot 91 2 family family NN cord-018437-yjvwa1ot 91 3 Adenoviridae Adenoviridae NNP cord-018437-yjvwa1ot 91 4 has have VBZ cord-018437-yjvwa1ot 91 5 not not RB cord-018437-yjvwa1ot 91 6 been be VBN cord-018437-yjvwa1ot 91 7 assigned assign VBN cord-018437-yjvwa1ot 91 8 to to IN cord-018437-yjvwa1ot 91 9 an an DT cord-018437-yjvwa1ot 91 10 order order NN cord-018437-yjvwa1ot 91 11 . . . cord-018437-yjvwa1ot 92 1 Within within IN cord-018437-yjvwa1ot 92 2 this this DT cord-018437-yjvwa1ot 92 3 family family NN cord-018437-yjvwa1ot 92 4 , , , cord-018437-yjvwa1ot 92 5 there there EX cord-018437-yjvwa1ot 92 6 are be VBP cord-018437-yjvwa1ot 92 7 fi fi FW cord-018437-yjvwa1ot 92 8 ve ve FW cord-018437-yjvwa1ot 92 9 genera genus NNS cord-018437-yjvwa1ot 92 10 . . . cord-018437-yjvwa1ot 93 1 The the DT cord-018437-yjvwa1ot 93 2 seven seven CD cord-018437-yjvwa1ot 93 3 species specie NNS cord-018437-yjvwa1ot 93 4 that that WDT cord-018437-yjvwa1ot 93 5 cause cause VBP cord-018437-yjvwa1ot 93 6 human human JJ cord-018437-yjvwa1ot 93 7 infection infection NN cord-018437-yjvwa1ot 93 8 are be VBP cord-018437-yjvwa1ot 93 9 Human human JJ cord-018437-yjvwa1ot 93 10 adenovirus adenovirus NN cord-018437-yjvwa1ot 93 11 A a NN cord-018437-yjvwa1ot 93 12 , , , cord-018437-yjvwa1ot 93 13 B B NNP cord-018437-yjvwa1ot 93 14 , , , cord-018437-yjvwa1ot 93 15 C C NNP cord-018437-yjvwa1ot 93 16 , , , cord-018437-yjvwa1ot 93 17 D D NNP cord-018437-yjvwa1ot 93 18 , , , cord-018437-yjvwa1ot 93 19 E E NNP cord-018437-yjvwa1ot 93 20 , , , cord-018437-yjvwa1ot 93 21 F F NNP cord-018437-yjvwa1ot 93 22 , , , cord-018437-yjvwa1ot 93 23 and and CC cord-018437-yjvwa1ot 93 24 G G NNP cord-018437-yjvwa1ot 93 25 , , , cord-018437-yjvwa1ot 93 26 all all RB cord-018437-yjvwa1ot 93 27 within within IN cord-018437-yjvwa1ot 93 28 the the DT cord-018437-yjvwa1ot 93 29 Mastadenovirus Mastadenovirus NNP cord-018437-yjvwa1ot 93 30 genus genus NN cord-018437-yjvwa1ot 93 31 ; ; : cord-018437-yjvwa1ot 93 32 there there EX cord-018437-yjvwa1ot 93 33 are be VBP cord-018437-yjvwa1ot 93 34 57 57 CD cord-018437-yjvwa1ot 93 35 accepted accept VBN cord-018437-yjvwa1ot 93 36 serotypes serotype NNS cord-018437-yjvwa1ot 93 37 ( ( -LRB- cord-018437-yjvwa1ot 93 38 Buckwalter Buckwalter NNP cord-018437-yjvwa1ot 93 39 et et NNP cord-018437-yjvwa1ot 93 40 al al NNP cord-018437-yjvwa1ot 93 41 . . NNP cord-018437-yjvwa1ot 93 42 2012 2012 CD cord-018437-yjvwa1ot 93 43 ) ) -RRB- cord-018437-yjvwa1ot 93 44 . . . cord-018437-yjvwa1ot 94 1 Endemic endemic JJ cord-018437-yjvwa1ot 94 2 respiratory respiratory JJ cord-018437-yjvwa1ot 94 3 infections infection NNS cord-018437-yjvwa1ot 94 4 are be VBP cord-018437-yjvwa1ot 94 5 most most RBS cord-018437-yjvwa1ot 94 6 commonly commonly RB cord-018437-yjvwa1ot 94 7 caused cause VBN cord-018437-yjvwa1ot 94 8 by by IN cord-018437-yjvwa1ot 94 9 serotypes serotype NNS cord-018437-yjvwa1ot 94 10 of of IN cord-018437-yjvwa1ot 94 11 Human human JJ cord-018437-yjvwa1ot 94 12 adenovirus adenovirus NN cord-018437-yjvwa1ot 94 13 C c NN cord-018437-yjvwa1ot 94 14 ( ( -LRB- cord-018437-yjvwa1ot 94 15 the the DT cord-018437-yjvwa1ot 94 16 type type NN cord-018437-yjvwa1ot 94 17 species specie NNS cord-018437-yjvwa1ot 94 18 of of IN cord-018437-yjvwa1ot 94 19 the the DT cord-018437-yjvwa1ot 94 20 genus genus NN cord-018437-yjvwa1ot 94 21 ) ) -RRB- cord-018437-yjvwa1ot 94 22 ; ; : cord-018437-yjvwa1ot 94 23 most most JJS cord-018437-yjvwa1ot 94 24 epidemic epidemic JJ cord-018437-yjvwa1ot 94 25 respiratory respiratory JJ cord-018437-yjvwa1ot 94 26 infections infection NNS cord-018437-yjvwa1ot 94 27 are be VBP cord-018437-yjvwa1ot 94 28 caused cause VBN cord-018437-yjvwa1ot 94 29 by by IN cord-018437-yjvwa1ot 94 30 serotypes serotype NNS cord-018437-yjvwa1ot 94 31 within within IN cord-018437-yjvwa1ot 94 32 species species NN cord-018437-yjvwa1ot 94 33 adenovirus adenovirus NN cord-018437-yjvwa1ot 94 34 B b NN cord-018437-yjvwa1ot 94 35 and and CC cord-018437-yjvwa1ot 94 36 adenovirus adenovirus NN cord-018437-yjvwa1ot 94 37 E e NN cord-018437-yjvwa1ot 94 38 . . . cord-018437-yjvwa1ot 95 1 Arenaviridae Arenaviridae NNP cord-018437-yjvwa1ot 95 2 : : : cord-018437-yjvwa1ot 96 1 Arenaviruses Arenaviruses NNP cord-018437-yjvwa1ot 96 2 may may MD cord-018437-yjvwa1ot 96 3 cause cause VB cord-018437-yjvwa1ot 96 4 several several JJ cord-018437-yjvwa1ot 96 5 hemorrhagic hemorrhagic JJ cord-018437-yjvwa1ot 96 6 fever fever NN cord-018437-yjvwa1ot 96 7 syndromes syndrome NNS cord-018437-yjvwa1ot 96 8 . . . cord-018437-yjvwa1ot 97 1 Specifi specifi NN cord-018437-yjvwa1ot 97 2 c c NN cord-018437-yjvwa1ot 97 3 rodents rodent NNS cord-018437-yjvwa1ot 97 4 are be VBP cord-018437-yjvwa1ot 97 5 the the DT cord-018437-yjvwa1ot 97 6 reservoir reservoir NN cord-018437-yjvwa1ot 97 7 for for IN cord-018437-yjvwa1ot 97 8 each each DT cord-018437-yjvwa1ot 97 9 arenavirus arenavirus NNP cord-018437-yjvwa1ot 97 10 ; ; : cord-018437-yjvwa1ot 97 11 human human JJ cord-018437-yjvwa1ot 97 12 disease disease NN cord-018437-yjvwa1ot 97 13 is be VBZ cord-018437-yjvwa1ot 97 14 incidental incidental JJ cord-018437-yjvwa1ot 97 15 and and CC cord-018437-yjvwa1ot 97 16 is be VBZ cord-018437-yjvwa1ot 97 17 usually usually RB cord-018437-yjvwa1ot 97 18 transmitted transmit VBN cord-018437-yjvwa1ot 97 19 by by IN cord-018437-yjvwa1ot 97 20 infectious infectious JJ cord-018437-yjvwa1ot 97 21 aerosols aerosol NNS cord-018437-yjvwa1ot 97 22 . . . cord-018437-yjvwa1ot 98 1 Viruses virus NNS cord-018437-yjvwa1ot 98 2 of of IN cord-018437-yjvwa1ot 98 3 this this DT cord-018437-yjvwa1ot 98 4 family family NN cord-018437-yjvwa1ot 98 5 are be VBP cord-018437-yjvwa1ot 98 6 enveloped envelop VBN cord-018437-yjvwa1ot 98 7 ; ; : cord-018437-yjvwa1ot 98 8 evenly evenly RB cord-018437-yjvwa1ot 98 9 spaced spaced JJ cord-018437-yjvwa1ot 98 10 glycoprotein glycoprotein NN cord-018437-yjvwa1ot 98 11 complexes complex NNS cord-018437-yjvwa1ot 98 12 ( ( -LRB- cord-018437-yjvwa1ot 98 13 a a DT cord-018437-yjvwa1ot 98 14 tetramer tetramer NN cord-018437-yjvwa1ot 98 15 of of IN cord-018437-yjvwa1ot 98 16 viral viral JJ cord-018437-yjvwa1ot 98 17 GP2 GP2 NNP cord-018437-yjvwa1ot 98 18 with with IN cord-018437-yjvwa1ot 98 19 viral viral JJ cord-018437-yjvwa1ot 98 20 GP1 gp1 NN cord-018437-yjvwa1ot 98 21 ionically ionically RB cord-018437-yjvwa1ot 98 22 bound bind VBN cord-018437-yjvwa1ot 98 23 as as IN cord-018437-yjvwa1ot 98 24 a a DT cord-018437-yjvwa1ot 98 25 globular globular JJ cord-018437-yjvwa1ot 98 26 head head NN cord-018437-yjvwa1ot 98 27 ) ) -RRB- cord-018437-yjvwa1ot 98 28 are be VBP cord-018437-yjvwa1ot 98 29 attached attach VBN cord-018437-yjvwa1ot 98 30 to to IN cord-018437-yjvwa1ot 98 31 the the DT cord-018437-yjvwa1ot 98 32 envelope envelope NN cord-018437-yjvwa1ot 98 33 giving give VBG cord-018437-yjvwa1ot 98 34 complete complete JJ cord-018437-yjvwa1ot 98 35 virions virion NNS cord-018437-yjvwa1ot 98 36 a a DT cord-018437-yjvwa1ot 98 37 studded studded JJ cord-018437-yjvwa1ot 98 38 spherical spherical JJ cord-018437-yjvwa1ot 98 39 morphology morphology NN cord-018437-yjvwa1ot 98 40 . . . cord-018437-yjvwa1ot 99 1 Complete complete JJ cord-018437-yjvwa1ot 99 2 virions virion NNS cord-018437-yjvwa1ot 99 3 are be VBP cord-018437-yjvwa1ot 99 4 ~100 ~100 VBG cord-018437-yjvwa1ot 99 5 nm nm NN cord-018437-yjvwa1ot 99 6 in in IN cord-018437-yjvwa1ot 99 7 diameter diameter NN cord-018437-yjvwa1ot 99 8 , , , cord-018437-yjvwa1ot 99 9 but but CC cord-018437-yjvwa1ot 99 10 show show VB cord-018437-yjvwa1ot 99 11 signifi signifi NNP cord-018437-yjvwa1ot 99 12 ca can MD cord-018437-yjvwa1ot 99 13 nt not RB cord-018437-yjvwa1ot 99 14 pleomorphism pleomorphism NN cord-018437-yjvwa1ot 99 15 ( ( -LRB- cord-018437-yjvwa1ot 99 16 range range NN cord-018437-yjvwa1ot 99 17 , , , cord-018437-yjvwa1ot 99 18 60 60 CD cord-018437-yjvwa1ot 99 19 - - SYM cord-018437-yjvwa1ot 99 20 300 300 CD cord-018437-yjvwa1ot 99 21 nm nm NN cord-018437-yjvwa1ot 99 22 ) ) -RRB- cord-018437-yjvwa1ot 99 23 . . . cord-018437-yjvwa1ot 100 1 The the DT cord-018437-yjvwa1ot 100 2 genome genome NN cord-018437-yjvwa1ot 100 3 is be VBZ cord-018437-yjvwa1ot 100 4 divided divide VBN cord-018437-yjvwa1ot 100 5 into into IN cord-018437-yjvwa1ot 100 6 two two CD cord-018437-yjvwa1ot 100 7 segments segment NNS cord-018437-yjvwa1ot 100 8 which which WDT cord-018437-yjvwa1ot 100 9 are be VBP cord-018437-yjvwa1ot 100 10 complexed complexe VBN cord-018437-yjvwa1ot 100 11 with with IN cord-018437-yjvwa1ot 100 12 nucleoproteins nucleoprotein NNS cord-018437-yjvwa1ot 100 13 ( ( -LRB- cord-018437-yjvwa1ot 100 14 Peters Peters NNP cord-018437-yjvwa1ot 100 15 2009 2009 CD cord-018437-yjvwa1ot 100 16 ) ) -RRB- cord-018437-yjvwa1ot 100 17 . . . cord-018437-yjvwa1ot 101 1 Complementary complementary JJ cord-018437-yjvwa1ot 101 2 sequences sequence NNS cord-018437-yjvwa1ot 101 3 at at IN cord-018437-yjvwa1ot 101 4 the the DT cord-018437-yjvwa1ot 101 5 3′ 3′ CD cord-018437-yjvwa1ot 101 6 and and CC cord-018437-yjvwa1ot 101 7 5′ 5′ NN cord-018437-yjvwa1ot 101 8 ends end NNS cord-018437-yjvwa1ot 101 9 of of IN cord-018437-yjvwa1ot 101 10 each each DT cord-018437-yjvwa1ot 101 11 segment segment NN cord-018437-yjvwa1ot 101 12 result result NN cord-018437-yjvwa1ot 101 13 in in IN cord-018437-yjvwa1ot 101 14 the the DT cord-018437-yjvwa1ot 101 15 formation formation NN cord-018437-yjvwa1ot 101 16 of of IN cord-018437-yjvwa1ot 101 17 two two CD cord-018437-yjvwa1ot 101 18 circular circular JJ cord-018437-yjvwa1ot 101 19 nucleocapsids nucleocapsid NNS cord-018437-yjvwa1ot 101 20 . . . cord-018437-yjvwa1ot 102 1 Arenaviruses arenavirus NNS cord-018437-yjvwa1ot 102 2 use use VBP cord-018437-yjvwa1ot 102 3 both both DT cord-018437-yjvwa1ot 102 4 negative negative JJ cord-018437-yjvwa1ot 102 5 - - HYPH cord-018437-yjvwa1ot 102 6 sense sense NN cord-018437-yjvwa1ot 102 7 and and CC cord-018437-yjvwa1ot 102 8 ambisense ambisense NN cord-018437-yjvwa1ot 102 9 coding coding NN cord-018437-yjvwa1ot 102 10 strategies strategy NNS cord-018437-yjvwa1ot 102 11 . . . cord-018437-yjvwa1ot 103 1 Host host NN cord-018437-yjvwa1ot 103 2 ribosomes ribosome NNS cord-018437-yjvwa1ot 103 3 are be VBP cord-018437-yjvwa1ot 103 4 often often RB cord-018437-yjvwa1ot 103 5 incorporated incorporate VBN cord-018437-yjvwa1ot 103 6 within within IN cord-018437-yjvwa1ot 103 7 the the DT cord-018437-yjvwa1ot 103 8 envelope envelope NN cord-018437-yjvwa1ot 103 9 of of IN cord-018437-yjvwa1ot 103 10 complete complete JJ cord-018437-yjvwa1ot 103 11 virions virion NNS cord-018437-yjvwa1ot 103 12 . . . cord-018437-yjvwa1ot 104 1 This this DT cord-018437-yjvwa1ot 104 2 family family NN cord-018437-yjvwa1ot 104 3 of of IN cord-018437-yjvwa1ot 104 4 viruses virus NNS cord-018437-yjvwa1ot 104 5 is be VBZ cord-018437-yjvwa1ot 104 6 not not RB cord-018437-yjvwa1ot 104 7 assigned assign VBN cord-018437-yjvwa1ot 104 8 to to IN cord-018437-yjvwa1ot 104 9 an an DT cord-018437-yjvwa1ot 104 10 order order NN cord-018437-yjvwa1ot 104 11 . . . cord-018437-yjvwa1ot 105 1 There there EX cord-018437-yjvwa1ot 105 2 is be VBZ cord-018437-yjvwa1ot 105 3 one one CD cord-018437-yjvwa1ot 105 4 genus genus NN cord-018437-yjvwa1ot 105 5 , , , cord-018437-yjvwa1ot 105 6 Arenavirus Arenavirus NNP cord-018437-yjvwa1ot 105 7 , , , cord-018437-yjvwa1ot 105 8 with with IN cord-018437-yjvwa1ot 105 9 25 25 CD cord-018437-yjvwa1ot 105 10 species specie NNS cord-018437-yjvwa1ot 105 11 that that WDT cord-018437-yjvwa1ot 105 12 fall fall VBP cord-018437-yjvwa1ot 105 13 into into IN cord-018437-yjvwa1ot 105 14 two two CD cord-018437-yjvwa1ot 105 15 complexes complex NNS cord-018437-yjvwa1ot 105 16 on on IN cord-018437-yjvwa1ot 105 17 the the DT cord-018437-yjvwa1ot 105 18 basis basis NN cord-018437-yjvwa1ot 105 19 of of IN cord-018437-yjvwa1ot 105 20 serologic serologic NN cord-018437-yjvwa1ot 105 21 and and CC cord-018437-yjvwa1ot 105 22 genetic genetic JJ cord-018437-yjvwa1ot 105 23 relatedness relatedness NN cord-018437-yjvwa1ot 105 24 . . . cord-018437-yjvwa1ot 106 1 The the DT cord-018437-yjvwa1ot 106 2 Old Old NNP cord-018437-yjvwa1ot 106 3 World World NNP cord-018437-yjvwa1ot 106 4 , , , cord-018437-yjvwa1ot 106 5 or or CC cord-018437-yjvwa1ot 106 6 African african JJ cord-018437-yjvwa1ot 106 7 , , , cord-018437-yjvwa1ot 106 8 species specie NNS cord-018437-yjvwa1ot 106 9 include include VBP cord-018437-yjvwa1ot 106 10 Lassa Lassa NNP cord-018437-yjvwa1ot 106 11 virus virus NN cord-018437-yjvwa1ot 106 12 ( ( -LRB- cord-018437-yjvwa1ot 106 13 Lassa Lassa NNP cord-018437-yjvwa1ot 106 14 fever fever NN cord-018437-yjvwa1ot 106 15 ) ) -RRB- cord-018437-yjvwa1ot 106 16 and and CC cord-018437-yjvwa1ot 106 17 Lujo Lujo NNP cord-018437-yjvwa1ot 106 18 virus virus NN cord-018437-yjvwa1ot 106 19 . . . cord-018437-yjvwa1ot 107 1 The the DT cord-018437-yjvwa1ot 107 2 New New NNP cord-018437-yjvwa1ot 107 3 World World NNP cord-018437-yjvwa1ot 107 4 species specie NNS cord-018437-yjvwa1ot 107 5 include include VBP cord-018437-yjvwa1ot 107 6 Guanarito Guanarito NNP cord-018437-yjvwa1ot 107 7 virus virus NN cord-018437-yjvwa1ot 107 8 ( ( -LRB- cord-018437-yjvwa1ot 107 9 Venezuelan venezuelan JJ cord-018437-yjvwa1ot 107 10 HF HF NNP cord-018437-yjvwa1ot 107 11 ) ) -RRB- cord-018437-yjvwa1ot 107 12 , , , cord-018437-yjvwa1ot 107 13 Junín Junín NNP cord-018437-yjvwa1ot 107 14 virus virus NN cord-018437-yjvwa1ot 107 15 ( ( -LRB- cord-018437-yjvwa1ot 107 16 Argentine argentine JJ cord-018437-yjvwa1ot 107 17 HF HF NNP cord-018437-yjvwa1ot 107 18 ) ) -RRB- cord-018437-yjvwa1ot 107 19 , , , cord-018437-yjvwa1ot 107 20 and and CC cord-018437-yjvwa1ot 107 21 Machupo Machupo NNP cord-018437-yjvwa1ot 107 22 virus virus NN cord-018437-yjvwa1ot 107 23 ( ( -LRB- cord-018437-yjvwa1ot 107 24 Bolivian bolivian JJ cord-018437-yjvwa1ot 107 25 HF HF NNP cord-018437-yjvwa1ot 107 26 ) ) -RRB- cord-018437-yjvwa1ot 107 27 . . . cord-018437-yjvwa1ot 108 1 The the DT cord-018437-yjvwa1ot 108 2 type type NN cord-018437-yjvwa1ot 108 3 species species NN cord-018437-yjvwa1ot 108 4 of of IN cord-018437-yjvwa1ot 108 5 the the DT cord-018437-yjvwa1ot 108 6 genus genus NN cord-018437-yjvwa1ot 108 7 Arenavirus Arenavirus NNP cord-018437-yjvwa1ot 108 8 is be VBZ cord-018437-yjvwa1ot 108 9 lymphocytic lymphocytic JJ cord-018437-yjvwa1ot 108 10 choriomeningitis choriomeningitis NNP cord-018437-yjvwa1ot 108 11 virus virus NN cord-018437-yjvwa1ot 108 12 . . . cord-018437-yjvwa1ot 109 1 Bunyaviridae Bunyaviridae NNP cord-018437-yjvwa1ot 109 2 : : : cord-018437-yjvwa1ot 110 1 Bunyaviruses Bunyaviruses NNP cord-018437-yjvwa1ot 110 2 may may MD cord-018437-yjvwa1ot 110 3 cause cause VB cord-018437-yjvwa1ot 110 4 several several JJ cord-018437-yjvwa1ot 110 5 hemorrhagic hemorrhagic JJ cord-018437-yjvwa1ot 110 6 fever fever NN cord-018437-yjvwa1ot 110 7 syndromes syndrome NNS cord-018437-yjvwa1ot 110 8 . . . cord-018437-yjvwa1ot 111 1 Viruses virus NNS cord-018437-yjvwa1ot 111 2 Coronaviridae Coronaviridae NNP cord-018437-yjvwa1ot 111 3 : : : cord-018437-yjvwa1ot 112 1 Transmembrane Transmembrane NNP cord-018437-yjvwa1ot 112 2 proteins protein NNS cord-018437-yjvwa1ot 112 3 produce produce VBP cord-018437-yjvwa1ot 112 4 blunt blunt JJ cord-018437-yjvwa1ot 112 5 projections projection NNS cord-018437-yjvwa1ot 112 6 from from IN cord-018437-yjvwa1ot 112 7 the the DT cord-018437-yjvwa1ot 112 8 surface surface NN cord-018437-yjvwa1ot 112 9 of of IN cord-018437-yjvwa1ot 112 10 coronaviruses coronaviruse NNS cord-018437-yjvwa1ot 112 11 , , , cord-018437-yjvwa1ot 112 12 resulting result VBG cord-018437-yjvwa1ot 112 13 in in IN cord-018437-yjvwa1ot 112 14 a a DT cord-018437-yjvwa1ot 112 15 " " `` cord-018437-yjvwa1ot 112 16 crown crown NN cord-018437-yjvwa1ot 112 17 - - HYPH cord-018437-yjvwa1ot 112 18 like like JJ cord-018437-yjvwa1ot 112 19 " " '' cord-018437-yjvwa1ot 112 20 appearance appearance NN cord-018437-yjvwa1ot 112 21 on on IN cord-018437-yjvwa1ot 112 22 electron electron NN cord-018437-yjvwa1ot 112 23 microscopic microscopic JJ cord-018437-yjvwa1ot 112 24 studies study NNS cord-018437-yjvwa1ot 112 25 ( ( -LRB- cord-018437-yjvwa1ot 112 26 100 100 CD cord-018437-yjvwa1ot 112 27 - - SYM cord-018437-yjvwa1ot 112 28 160 160 CD cord-018437-yjvwa1ot 112 29 nm nm NN cord-018437-yjvwa1ot 112 30 in in IN cord-018437-yjvwa1ot 112 31 diameter diameter NN cord-018437-yjvwa1ot 112 32 ) ) -RRB- cord-018437-yjvwa1ot 112 33 . . . cord-018437-yjvwa1ot 113 1 Translation translation NN cord-018437-yjvwa1ot 113 2 of of IN cord-018437-yjvwa1ot 113 3 the the DT cord-018437-yjvwa1ot 113 4 coronavirus coronavirus NN cord-018437-yjvwa1ot 113 5 genome genome NN cord-018437-yjvwa1ot 113 6 is be VBZ cord-018437-yjvwa1ot 113 7 unique unique JJ cord-018437-yjvwa1ot 113 8 and and CC cord-018437-yjvwa1ot 113 9 includes include VBZ cord-018437-yjvwa1ot 113 10 production production NN cord-018437-yjvwa1ot 113 11 of of IN cord-018437-yjvwa1ot 113 12 polyproteins polyprotein NNS cord-018437-yjvwa1ot 113 13 , , , cord-018437-yjvwa1ot 113 14 discontinuous discontinuous JJ cord-018437-yjvwa1ot 113 15 synthesis synthesis NN cord-018437-yjvwa1ot 113 16 , , , cord-018437-yjvwa1ot 113 17 overlapping overlap VBG cord-018437-yjvwa1ot 113 18 reading reading NN cord-018437-yjvwa1ot 113 19 frames frame NNS cord-018437-yjvwa1ot 113 20 , , , cord-018437-yjvwa1ot 113 21 ribosomal ribosomal JJ cord-018437-yjvwa1ot 113 22 frame frame NN cord-018437-yjvwa1ot 113 23 shifting shift VBG cord-018437-yjvwa1ot 113 24 , , , cord-018437-yjvwa1ot 113 25 and and CC cord-018437-yjvwa1ot 113 26 post post JJ cord-018437-yjvwa1ot 113 27 - - JJ cord-018437-yjvwa1ot 113 28 translational translational JJ cord-018437-yjvwa1ot 113 29 proteolytic proteolytic JJ cord-018437-yjvwa1ot 113 30 processing processing NN cord-018437-yjvwa1ot 113 31 ( ( -LRB- cord-018437-yjvwa1ot 113 32 Marra Marra NNP cord-018437-yjvwa1ot 113 33 et et NNP cord-018437-yjvwa1ot 113 34 al al NNP cord-018437-yjvwa1ot 113 35 . . NNP cord-018437-yjvwa1ot 113 36 2003 2003 CD cord-018437-yjvwa1ot 113 37 ; ; : cord-018437-yjvwa1ot 113 38 Rota Rota NNP cord-018437-yjvwa1ot 113 39 et et NNP cord-018437-yjvwa1ot 113 40 al al NNP cord-018437-yjvwa1ot 113 41 . . . cord-018437-yjvwa1ot 114 1 2003 2003 CD cord-018437-yjvwa1ot 114 2 ; ; : cord-018437-yjvwa1ot 114 3 Theil Theil NNP cord-018437-yjvwa1ot 114 4 et et NNP cord-018437-yjvwa1ot 114 5 al al NNP cord-018437-yjvwa1ot 114 6 . . NNP cord-018437-yjvwa1ot 114 7 2003 2003 CD cord-018437-yjvwa1ot 114 8 ) ) -RRB- cord-018437-yjvwa1ot 114 9 . . . cord-018437-yjvwa1ot 115 1 The the DT cord-018437-yjvwa1ot 115 2 major major JJ cord-018437-yjvwa1ot 115 3 structural structural JJ cord-018437-yjvwa1ot 115 4 proteins protein NNS cord-018437-yjvwa1ot 115 5 , , , cord-018437-yjvwa1ot 115 6 spike spike NN cord-018437-yjvwa1ot 115 7 glycoprotein glycoprotein NN cord-018437-yjvwa1ot 115 8 ( ( -LRB- cord-018437-yjvwa1ot 115 9 S S NNP cord-018437-yjvwa1ot 115 10 ) ) -RRB- cord-018437-yjvwa1ot 115 11 , , , cord-018437-yjvwa1ot 115 12 membrane membrane NN cord-018437-yjvwa1ot 115 13 glycoprotein glycoprotein NN cord-018437-yjvwa1ot 115 14 ( ( -LRB- cord-018437-yjvwa1ot 115 15 M M NNP cord-018437-yjvwa1ot 115 16 ) ) -RRB- cord-018437-yjvwa1ot 115 17 , , , cord-018437-yjvwa1ot 115 18 nucleocapsid nucleocapsid NNP cord-018437-yjvwa1ot 115 19 phosphoprotein phosphoprotein NNP cord-018437-yjvwa1ot 115 20 ( ( -LRB- cord-018437-yjvwa1ot 115 21 N N NNP cord-018437-yjvwa1ot 115 22 ) ) -RRB- cord-018437-yjvwa1ot 115 23 , , , cord-018437-yjvwa1ot 115 24 hemagglutinin hemagglutinin NN cord-018437-yjvwa1ot 115 25 - - HYPH cord-018437-yjvwa1ot 115 26 esterase esterase NN cord-018437-yjvwa1ot 115 27 glycoprotein glycoprotein NN cord-018437-yjvwa1ot 115 28 ( ( -LRB- cord-018437-yjvwa1ot 115 29 HE HE NNP cord-018437-yjvwa1ot 115 30 ) ) -RRB- cord-018437-yjvwa1ot 115 31 , , , cord-018437-yjvwa1ot 115 32 and and CC cord-018437-yjvwa1ot 115 33 envelope envelope NN cord-018437-yjvwa1ot 115 34 protein protein NN cord-018437-yjvwa1ot 115 35 ( ( -LRB- cord-018437-yjvwa1ot 115 36 E E NNP cord-018437-yjvwa1ot 115 37 ) ) -RRB- cord-018437-yjvwa1ot 115 38 , , , cord-018437-yjvwa1ot 115 39 are be VBP cord-018437-yjvwa1ot 115 40 present present JJ cord-018437-yjvwa1ot 115 41 in in IN cord-018437-yjvwa1ot 115 42 all all DT cord-018437-yjvwa1ot 115 43 coronaviruses coronaviruse NNS cord-018437-yjvwa1ot 115 44 . . . cord-018437-yjvwa1ot 116 1 Nonstructural nonstructural JJ cord-018437-yjvwa1ot 116 2 proteins protein NNS cord-018437-yjvwa1ot 116 3 are be VBP cord-018437-yjvwa1ot 116 4 encoded encode VBN cord-018437-yjvwa1ot 116 5 in in IN cord-018437-yjvwa1ot 116 6 5 5 CD cord-018437-yjvwa1ot 116 7 - - SYM cord-018437-yjvwa1ot 116 8 10 10 CD cord-018437-yjvwa1ot 116 9 unique unique JJ cord-018437-yjvwa1ot 116 10 or or CC cord-018437-yjvwa1ot 116 11 overlapping overlapping JJ cord-018437-yjvwa1ot 116 12 reading reading NN cord-018437-yjvwa1ot 116 13 frames frame NNS cord-018437-yjvwa1ot 116 14 ( ( -LRB- cord-018437-yjvwa1ot 116 15 Lai Lai NNP cord-018437-yjvwa1ot 116 16 et et FW cord-018437-yjvwa1ot 116 17 al al NNP cord-018437-yjvwa1ot 116 18 . . NNP cord-018437-yjvwa1ot 116 19 2007 2007 CD cord-018437-yjvwa1ot 116 20 ) ) -RRB- cord-018437-yjvwa1ot 116 21 . . . cord-018437-yjvwa1ot 117 1 The the DT cord-018437-yjvwa1ot 117 2 human human JJ cord-018437-yjvwa1ot 117 3 coronaviruses coronaviruse NNS cord-018437-yjvwa1ot 117 4 are be VBP cord-018437-yjvwa1ot 117 5 assigned assign VBN cord-018437-yjvwa1ot 117 6 to to IN cord-018437-yjvwa1ot 117 7 the the DT cord-018437-yjvwa1ot 117 8 order order NN cord-018437-yjvwa1ot 117 9 Nidovirales Nidovirales NNP cord-018437-yjvwa1ot 117 10 , , , cord-018437-yjvwa1ot 117 11 family family NN cord-018437-yjvwa1ot 117 12 Coronaviridae Coronaviridae NNP cord-018437-yjvwa1ot 117 13 , , , cord-018437-yjvwa1ot 117 14 and and CC cord-018437-yjvwa1ot 117 15 subfamily subfamily RB cord-018437-yjvwa1ot 117 16 Coronavirinae Coronavirinae NNP cord-018437-yjvwa1ot 117 17 . . . cord-018437-yjvwa1ot 118 1 There there EX cord-018437-yjvwa1ot 118 2 are be VBP cord-018437-yjvwa1ot 118 3 four four CD cord-018437-yjvwa1ot 118 4 genera genus NNS cord-018437-yjvwa1ot 118 5 and and CC cord-018437-yjvwa1ot 118 6 three three CD cord-018437-yjvwa1ot 118 7 serological serological JJ cord-018437-yjvwa1ot 118 8 groups group NNS cord-018437-yjvwa1ot 118 9 . . . cord-018437-yjvwa1ot 119 1 Relevant relevant JJ cord-018437-yjvwa1ot 119 2 viruses virus NNS cord-018437-yjvwa1ot 119 3 include include VBP cord-018437-yjvwa1ot 119 4 Human human JJ cord-018437-yjvwa1ot 119 5 coronavirus coronavirus NN cord-018437-yjvwa1ot 119 6 229E 229e CD cord-018437-yjvwa1ot 119 7 and and CC cord-018437-yjvwa1ot 119 8 Human human JJ cord-018437-yjvwa1ot 119 9 coronavirus coronavirus NN cord-018437-yjvwa1ot 119 10 NL63 NL63 NNP cord-018437-yjvwa1ot 119 11 of of IN cord-018437-yjvwa1ot 119 12 the the DT cord-018437-yjvwa1ot 119 13 genus genus NN cord-018437-yjvwa1ot 119 14 Alphacoronavirus Alphacoronavirus NNP cord-018437-yjvwa1ot 119 15 ( ( -LRB- cord-018437-yjvwa1ot 119 16 antigenic antigenic JJ cord-018437-yjvwa1ot 119 17 group group NN cord-018437-yjvwa1ot 119 18 I I NNP cord-018437-yjvwa1ot 119 19 ) ) -RRB- cord-018437-yjvwa1ot 119 20 , , , cord-018437-yjvwa1ot 119 21 Human human JJ cord-018437-yjvwa1ot 119 22 coronavirus coronavirus NN cord-018437-yjvwa1ot 119 23 HKU1 HKU1 NNP cord-018437-yjvwa1ot 119 24 , , , cord-018437-yjvwa1ot 119 25 Betacoronavirus Betacoronavirus NNP cord-018437-yjvwa1ot 119 26 1 1 CD cord-018437-yjvwa1ot 119 27 and and CC cord-018437-yjvwa1ot 119 28 Severe severe JJ cord-018437-yjvwa1ot 119 29 acute acute JJ cord-018437-yjvwa1ot 119 30 respiratory respiratory JJ cord-018437-yjvwa1ot 119 31 syndrome syndrome NN cord-018437-yjvwa1ot 119 32 - - HYPH cord-018437-yjvwa1ot 119 33 related relate VBN cord-018437-yjvwa1ot 119 34 coronavirus coronavirus NN cord-018437-yjvwa1ot 119 35 of of IN cord-018437-yjvwa1ot 119 36 the the DT cord-018437-yjvwa1ot 119 37 genus genus NN cord-018437-yjvwa1ot 119 38 Betacoronavirus Betacoronavirus NNP cord-018437-yjvwa1ot 119 39 ( ( -LRB- cord-018437-yjvwa1ot 119 40 antigenic antigenic JJ cord-018437-yjvwa1ot 119 41 group group NN cord-018437-yjvwa1ot 119 42 II II NNP cord-018437-yjvwa1ot 119 43 ) ) -RRB- cord-018437-yjvwa1ot 119 44 . . . cord-018437-yjvwa1ot 120 1 Filoviridae Filoviridae NNP cord-018437-yjvwa1ot 120 2 : : : cord-018437-yjvwa1ot 121 1 Filoviruses filovirus NNS cord-018437-yjvwa1ot 121 2 may may MD cord-018437-yjvwa1ot 121 3 cause cause VB cord-018437-yjvwa1ot 121 4 several several JJ cord-018437-yjvwa1ot 121 5 hemorrhagic hemorrhagic JJ cord-018437-yjvwa1ot 121 6 fever fever NN cord-018437-yjvwa1ot 121 7 syndromes syndrome NNS cord-018437-yjvwa1ot 121 8 . . . cord-018437-yjvwa1ot 122 1 The the DT cord-018437-yjvwa1ot 122 2 fi fi NNP cord-018437-yjvwa1ot 122 3 loviruses loviruse NNS cord-018437-yjvwa1ot 122 4 have have VBP cord-018437-yjvwa1ot 122 5 a a DT cord-018437-yjvwa1ot 122 6 unique unique JJ cord-018437-yjvwa1ot 122 7 threadlike threadlike JJ cord-018437-yjvwa1ot 122 8 morphology morphology NN cord-018437-yjvwa1ot 122 9 . . . cord-018437-yjvwa1ot 123 1 The the DT cord-018437-yjvwa1ot 123 2 helical helical JJ cord-018437-yjvwa1ot 123 3 nucleocapsids nucleocapsid NNS cord-018437-yjvwa1ot 123 4 are be VBP cord-018437-yjvwa1ot 123 5 surrounded surround VBN cord-018437-yjvwa1ot 123 6 by by IN cord-018437-yjvwa1ot 123 7 an an DT cord-018437-yjvwa1ot 123 8 envelope envelope NN cord-018437-yjvwa1ot 123 9 studded stud VBN cord-018437-yjvwa1ot 123 10 by by IN cord-018437-yjvwa1ot 123 11 spikes spike NNS cord-018437-yjvwa1ot 123 12 formed form VBN cord-018437-yjvwa1ot 123 13 by by IN cord-018437-yjvwa1ot 123 14 a a DT cord-018437-yjvwa1ot 123 15 single single JJ cord-018437-yjvwa1ot 123 16 type type NN cord-018437-yjvwa1ot 123 17 of of IN cord-018437-yjvwa1ot 123 18 glycoprotein glycoprotein NN cord-018437-yjvwa1ot 123 19 ( ( -LRB- cord-018437-yjvwa1ot 123 20 GP GP NNP cord-018437-yjvwa1ot 123 21 ) ) -RRB- cord-018437-yjvwa1ot 123 22 . . . cord-018437-yjvwa1ot 124 1 The the DT cord-018437-yjvwa1ot 124 2 genome genome NN cord-018437-yjvwa1ot 124 3 consists consist VBZ cord-018437-yjvwa1ot 124 4 of of IN cord-018437-yjvwa1ot 124 5 a a DT cord-018437-yjvwa1ot 124 6 single single JJ cord-018437-yjvwa1ot 124 7 segment segment NN cord-018437-yjvwa1ot 124 8 of of IN cord-018437-yjvwa1ot 124 9 negative negative JJ cord-018437-yjvwa1ot 124 10 - - HYPH cord-018437-yjvwa1ot 124 11 sense sense NN cord-018437-yjvwa1ot 124 12 ssRNA ssrna NN cord-018437-yjvwa1ot 124 13 that that WDT cord-018437-yjvwa1ot 124 14 encodes encode VBZ cord-018437-yjvwa1ot 124 15 for for IN cord-018437-yjvwa1ot 124 16 seven seven CD cord-018437-yjvwa1ot 124 17 proteins protein NNS cord-018437-yjvwa1ot 124 18 ( ( -LRB- cord-018437-yjvwa1ot 124 19 Kuhn Kuhn NNP cord-018437-yjvwa1ot 124 20 et et NNP cord-018437-yjvwa1ot 124 21 al al NNP cord-018437-yjvwa1ot 124 22 . . NNP cord-018437-yjvwa1ot 124 23 2010 2010 CD cord-018437-yjvwa1ot 124 24 ) ) -RRB- cord-018437-yjvwa1ot 124 25 . . . cord-018437-yjvwa1ot 125 1 The the DT cord-018437-yjvwa1ot 125 2 presence presence NN cord-018437-yjvwa1ot 125 3 of of IN cord-018437-yjvwa1ot 125 4 gene gene NN cord-018437-yjvwa1ot 125 5 overlap overlap NN cord-018437-yjvwa1ot 125 6 for for IN cord-018437-yjvwa1ot 125 7 several several JJ cord-018437-yjvwa1ot 125 8 genes gene NNS cord-018437-yjvwa1ot 125 9 is be VBZ cord-018437-yjvwa1ot 125 10 an an DT cord-018437-yjvwa1ot 125 11 unusual unusual JJ cord-018437-yjvwa1ot 125 12 feature feature NN cord-018437-yjvwa1ot 125 13 of of IN cord-018437-yjvwa1ot 125 14 fi fi NNP cord-018437-yjvwa1ot 125 15 loviruses loviruse NNS cord-018437-yjvwa1ot 125 16 . . . cord-018437-yjvwa1ot 126 1 In in IN cord-018437-yjvwa1ot 126 2 ebolaviruses ebolaviruse NNS cord-018437-yjvwa1ot 126 3 , , , cord-018437-yjvwa1ot 126 4 the the DT cord-018437-yjvwa1ot 126 5 surface surface NN cord-018437-yjvwa1ot 126 6 glycoprotein glycoprotein NN cord-018437-yjvwa1ot 126 7 is be VBZ cord-018437-yjvwa1ot 126 8 encoded encode VBN cord-018437-yjvwa1ot 126 9 by by IN cord-018437-yjvwa1ot 126 10 two two CD cord-018437-yjvwa1ot 126 11 adjacent adjacent JJ cord-018437-yjvwa1ot 126 12 reading reading NN cord-018437-yjvwa1ot 126 13 frames frame NNS cord-018437-yjvwa1ot 126 14 . . . cord-018437-yjvwa1ot 127 1 A a DT cord-018437-yjvwa1ot 127 2 truncated truncated JJ cord-018437-yjvwa1ot 127 3 version version NN cord-018437-yjvwa1ot 127 4 ( ( -LRB- cord-018437-yjvwa1ot 127 5 sGP sGP NNP cord-018437-yjvwa1ot 127 6 ) ) -RRB- cord-018437-yjvwa1ot 127 7 , , , cord-018437-yjvwa1ot 127 8 which which WDT cord-018437-yjvwa1ot 127 9 lacks lack VBZ cord-018437-yjvwa1ot 127 10 the the DT cord-018437-yjvwa1ot 127 11 hydrophobic hydrophobic JJ cord-018437-yjvwa1ot 127 12 anchor anchor NN cord-018437-yjvwa1ot 127 13 , , , cord-018437-yjvwa1ot 127 14 results result VBZ cord-018437-yjvwa1ot 127 15 from from IN cord-018437-yjvwa1ot 127 16 translation translation NN cord-018437-yjvwa1ot 127 17 of of IN cord-018437-yjvwa1ot 127 18 the the DT cord-018437-yjvwa1ot 127 19 upstream upstream JJ cord-018437-yjvwa1ot 127 20 reading reading NN cord-018437-yjvwa1ot 127 21 frame frame NN cord-018437-yjvwa1ot 127 22 only only RB cord-018437-yjvwa1ot 127 23 . . . cord-018437-yjvwa1ot 128 1 This this DT cord-018437-yjvwa1ot 128 2 protein protein NN cord-018437-yjvwa1ot 128 3 is be VBZ cord-018437-yjvwa1ot 128 4 secreted secrete VBN cord-018437-yjvwa1ot 128 5 from from IN cord-018437-yjvwa1ot 128 6 cells cell NNS cord-018437-yjvwa1ot 128 7 and and CC cord-018437-yjvwa1ot 128 8 may may MD cord-018437-yjvwa1ot 128 9 serve serve VB cord-018437-yjvwa1ot 128 10 as as IN cord-018437-yjvwa1ot 128 11 a a DT cord-018437-yjvwa1ot 128 12 decoy decoy NN cord-018437-yjvwa1ot 128 13 for for IN cord-018437-yjvwa1ot 128 14 the the DT cord-018437-yjvwa1ot 128 15 host host NN cord-018437-yjvwa1ot 128 16 's 's POS cord-018437-yjvwa1ot 128 17 immunological immunological JJ cord-018437-yjvwa1ot 128 18 response response NN cord-018437-yjvwa1ot 128 19 . . . cord-018437-yjvwa1ot 129 1 The the DT cord-018437-yjvwa1ot 129 2 full full JJ cord-018437-yjvwa1ot 129 3 - - HYPH cord-018437-yjvwa1ot 129 4 length length NN cord-018437-yjvwa1ot 129 5 GP gp NN cord-018437-yjvwa1ot 129 6 is be VBZ cord-018437-yjvwa1ot 129 7 formed form VBN cord-018437-yjvwa1ot 129 8 only only RB cord-018437-yjvwa1ot 129 9 when when WRB cord-018437-yjvwa1ot 129 10 the the DT cord-018437-yjvwa1ot 129 11 RNA RNA NNP cord-018437-yjvwa1ot 129 12 polymerase polymerase NN cord-018437-yjvwa1ot 129 13 misreads misread VBZ cord-018437-yjvwa1ot 129 14 a a DT cord-018437-yjvwa1ot 129 15 poly poly JJ cord-018437-yjvwa1ot 129 16 - - HYPH cord-018437-yjvwa1ot 129 17 U u JJ cord-018437-yjvwa1ot 129 18 editing editing NN cord-018437-yjvwa1ot 129 19 site site NN cord-018437-yjvwa1ot 129 20 between between IN cord-018437-yjvwa1ot 129 21 the the DT cord-018437-yjvwa1ot 129 22 reading reading NN cord-018437-yjvwa1ot 129 23 frames frame NNS cord-018437-yjvwa1ot 129 24 . . . cord-018437-yjvwa1ot 130 1 The the DT cord-018437-yjvwa1ot 130 2 fulllength fulllength NN cord-018437-yjvwa1ot 130 3 GP gp NN cord-018437-yjvwa1ot 130 4 is be VBZ cord-018437-yjvwa1ot 130 5 inserted insert VBN cord-018437-yjvwa1ot 130 6 , , , cord-018437-yjvwa1ot 130 7 as as IN cord-018437-yjvwa1ot 130 8 homotrimers homotrimer NNS cord-018437-yjvwa1ot 130 9 , , , cord-018437-yjvwa1ot 130 10 into into IN cord-018437-yjvwa1ot 130 11 the the DT cord-018437-yjvwa1ot 130 12 host host NN cord-018437-yjvwa1ot 130 13 membranes membrane NNS cord-018437-yjvwa1ot 130 14 that that WDT cord-018437-yjvwa1ot 130 15 will will MD cord-018437-yjvwa1ot 130 16 form form VB cord-018437-yjvwa1ot 130 17 the the DT cord-018437-yjvwa1ot 130 18 virion virion NN cord-018437-yjvwa1ot 130 19 envelope envelope NN cord-018437-yjvwa1ot 130 20 . . . cord-018437-yjvwa1ot 131 1 A a DT cord-018437-yjvwa1ot 131 2 helical helical JJ cord-018437-yjvwa1ot 131 3 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 131 4 is be VBZ cord-018437-yjvwa1ot 131 5 formed form VBN cord-018437-yjvwa1ot 131 6 by by IN cord-018437-yjvwa1ot 131 7 association association NN cord-018437-yjvwa1ot 131 8 of of IN cord-018437-yjvwa1ot 131 9 the the DT cord-018437-yjvwa1ot 131 10 ssRNA ssrna NN cord-018437-yjvwa1ot 131 11 with with IN cord-018437-yjvwa1ot 131 12 nucleoproteins nucleoprotein NNS cord-018437-yjvwa1ot 131 13 . . . cord-018437-yjvwa1ot 132 1 The the DT cord-018437-yjvwa1ot 132 2 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 132 3 is be VBZ cord-018437-yjvwa1ot 132 4 ~50 ~50 NFP cord-018437-yjvwa1ot 132 5 nm nm NN cord-018437-yjvwa1ot 132 6 in in IN cord-018437-yjvwa1ot 132 7 diameter diameter NN cord-018437-yjvwa1ot 132 8 , , , cord-018437-yjvwa1ot 132 9 with with IN cord-018437-yjvwa1ot 132 10 a a DT cord-018437-yjvwa1ot 132 11 central central JJ cord-018437-yjvwa1ot 132 12 axial axial JJ cord-018437-yjvwa1ot 132 13 space space NN cord-018437-yjvwa1ot 132 14 ~20 ~20 NFP cord-018437-yjvwa1ot 132 15 nm nm NN cord-018437-yjvwa1ot 132 16 in in IN cord-018437-yjvwa1ot 132 17 diameter diameter NN cord-018437-yjvwa1ot 132 18 . . . cord-018437-yjvwa1ot 133 1 The the DT cord-018437-yjvwa1ot 133 2 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 133 3 is be VBZ cord-018437-yjvwa1ot 133 4 attached attach VBN cord-018437-yjvwa1ot 133 5 to to IN cord-018437-yjvwa1ot 133 6 the the DT cord-018437-yjvwa1ot 133 7 envelope envelope NN cord-018437-yjvwa1ot 133 8 by by IN cord-018437-yjvwa1ot 133 9 matrix matrix NN cord-018437-yjvwa1ot 133 10 protein protein NN cord-018437-yjvwa1ot 133 11 . . . cord-018437-yjvwa1ot 134 1 The the DT cord-018437-yjvwa1ot 134 2 complete complete JJ cord-018437-yjvwa1ot 134 3 virions virion NNS cord-018437-yjvwa1ot 134 4 are be VBP cord-018437-yjvwa1ot 134 5 ~80 ~80 ADD cord-018437-yjvwa1ot 134 6 nm nm NN cord-018437-yjvwa1ot 134 7 in in IN cord-018437-yjvwa1ot 134 8 diameter diameter NN cord-018437-yjvwa1ot 134 9 , , , cord-018437-yjvwa1ot 134 10 but but CC cord-018437-yjvwa1ot 134 11 the the DT cord-018437-yjvwa1ot 134 12 virion virion NN cord-018437-yjvwa1ot 134 13 length length NN cord-018437-yjvwa1ot 134 14 may may MD cord-018437-yjvwa1ot 134 15 vary vary VB cord-018437-yjvwa1ot 134 16 from from IN cord-018437-yjvwa1ot 134 17 800 800 CD cord-018437-yjvwa1ot 134 18 to to TO cord-018437-yjvwa1ot 134 19 10,000 10,000 CD cord-018437-yjvwa1ot 134 20 nm nm NN cord-018437-yjvwa1ot 134 21 . . . cord-018437-yjvwa1ot 135 1 The the DT cord-018437-yjvwa1ot 135 2 family family NN cord-018437-yjvwa1ot 135 3 Filoviridae Filoviridae NNP cord-018437-yjvwa1ot 135 4 is be VBZ cord-018437-yjvwa1ot 135 5 assigned assign VBN cord-018437-yjvwa1ot 135 6 to to IN cord-018437-yjvwa1ot 135 7 the the DT cord-018437-yjvwa1ot 135 8 order order NN cord-018437-yjvwa1ot 135 9 Mononegavirales Mononegavirales NNP cord-018437-yjvwa1ot 135 10 . . . cord-018437-yjvwa1ot 136 1 There there EX cord-018437-yjvwa1ot 136 2 are be VBP cord-018437-yjvwa1ot 136 3 two two CD cord-018437-yjvwa1ot 136 4 genera genus NNS cord-018437-yjvwa1ot 136 5 within within IN cord-018437-yjvwa1ot 136 6 the the DT cord-018437-yjvwa1ot 136 7 family family NN cord-018437-yjvwa1ot 136 8 Ebolavirus Ebolavirus NNP cord-018437-yjvwa1ot 136 9 and and CC cord-018437-yjvwa1ot 136 10 Marburgvirus Marburgvirus NNP cord-018437-yjvwa1ot 136 11 . . . cord-018437-yjvwa1ot 137 1 There there EX cord-018437-yjvwa1ot 137 2 are be VBP cord-018437-yjvwa1ot 137 3 fi fi NNP cord-018437-yjvwa1ot 137 4 ve ve NNP cord-018437-yjvwa1ot 137 5 ebolavirus ebolavirus NN cord-018437-yjvwa1ot 137 6 species specie NNS cord-018437-yjvwa1ot 137 7 , , , cord-018437-yjvwa1ot 137 8 including include VBG cord-018437-yjvwa1ot 137 9 Sudan Sudan NNP cord-018437-yjvwa1ot 137 10 ebolavirus ebolavirus NN cord-018437-yjvwa1ot 137 11 and and CC cord-018437-yjvwa1ot 137 12 Zaire Zaire NNP cord-018437-yjvwa1ot 137 13 ebolavirus ebolavirus NN cord-018437-yjvwa1ot 137 14 ( ( -LRB- cord-018437-yjvwa1ot 137 15 the the DT cord-018437-yjvwa1ot 137 16 type type NN cord-018437-yjvwa1ot 137 17 species species NN cord-018437-yjvwa1ot 137 18 ) ) -RRB- cord-018437-yjvwa1ot 137 19 . . . cord-018437-yjvwa1ot 138 1 The the DT cord-018437-yjvwa1ot 138 2 genus genus NN cord-018437-yjvwa1ot 138 3 Marburgvirus Marburgvirus NNP cord-018437-yjvwa1ot 138 4 consists consist VBZ cord-018437-yjvwa1ot 138 5 of of IN cord-018437-yjvwa1ot 138 6 one one CD cord-018437-yjvwa1ot 138 7 species specie NNS cord-018437-yjvwa1ot 138 8 , , , cord-018437-yjvwa1ot 138 9 Marburg Marburg NNP cord-018437-yjvwa1ot 138 10 marburgvirus marburgvirus NNP cord-018437-yjvwa1ot 138 11 . . . cord-018437-yjvwa1ot 139 1 Humans human NNS cord-018437-yjvwa1ot 139 2 and and CC cord-018437-yjvwa1ot 139 3 nonhuman nonhuman NN cord-018437-yjvwa1ot 139 4 primates primate NNS cord-018437-yjvwa1ot 139 5 are be VBP cord-018437-yjvwa1ot 139 6 susceptible susceptible JJ cord-018437-yjvwa1ot 139 7 to to IN cord-018437-yjvwa1ot 139 8 ebolavirus ebolavirus NN cord-018437-yjvwa1ot 139 9 and and CC cord-018437-yjvwa1ot 139 10 marburgvirus marburgvirus NNP cord-018437-yjvwa1ot 139 11 infection infection NN cord-018437-yjvwa1ot 139 12 ; ; : cord-018437-yjvwa1ot 139 13 the the DT cord-018437-yjvwa1ot 139 14 host host NN cord-018437-yjvwa1ot 139 15 reservoirs reservoir NNS cord-018437-yjvwa1ot 139 16 for for IN cord-018437-yjvwa1ot 139 17 these these DT cord-018437-yjvwa1ot 139 18 viruses virus NNS cord-018437-yjvwa1ot 139 19 are be VBP cord-018437-yjvwa1ot 139 20 unknown unknown JJ cord-018437-yjvwa1ot 139 21 . . . cord-018437-yjvwa1ot 140 1 Humans human NNS cord-018437-yjvwa1ot 140 2 may may MD cord-018437-yjvwa1ot 140 3 be be VB cord-018437-yjvwa1ot 140 4 infected infect VBN cord-018437-yjvwa1ot 140 5 sporadically sporadically RB cord-018437-yjvwa1ot 140 6 by by IN cord-018437-yjvwa1ot 140 7 presumed presume VBN cord-018437-yjvwa1ot 140 8 contact contact NN cord-018437-yjvwa1ot 140 9 with with IN cord-018437-yjvwa1ot 140 10 the the DT cord-018437-yjvwa1ot 140 11 host host NN cord-018437-yjvwa1ot 140 12 species specie NNS cord-018437-yjvwa1ot 140 13 or or CC cord-018437-yjvwa1ot 140 14 by by IN cord-018437-yjvwa1ot 140 15 direct direct JJ cord-018437-yjvwa1ot 140 16 contact contact NN cord-018437-yjvwa1ot 140 17 with with IN cord-018437-yjvwa1ot 140 18 virus virus NN cord-018437-yjvwa1ot 140 19 containing contain VBG cord-018437-yjvwa1ot 140 20 body body NN cord-018437-yjvwa1ot 140 21 fl fl NNP cord-018437-yjvwa1ot 140 22 uids uid NNS cord-018437-yjvwa1ot 140 23 taken take VBN cord-018437-yjvwa1ot 140 24 from from IN cord-018437-yjvwa1ot 140 25 acutely acutely RB cord-018437-yjvwa1ot 140 26 infected infected JJ cord-018437-yjvwa1ot 140 27 humans human NNS cord-018437-yjvwa1ot 140 28 or or CC cord-018437-yjvwa1ot 140 29 nonhuman nonhuman NN cord-018437-yjvwa1ot 140 30 primates primate NNS cord-018437-yjvwa1ot 140 31 . . . cord-018437-yjvwa1ot 141 1 Nosocomial nosocomial JJ cord-018437-yjvwa1ot 141 2 and and CC cord-018437-yjvwa1ot 141 3 laboratoryacquired laboratoryacquired JJ cord-018437-yjvwa1ot 141 4 infections infection NNS cord-018437-yjvwa1ot 141 5 are be VBP cord-018437-yjvwa1ot 141 6 well well RB cord-018437-yjvwa1ot 141 7 described describe VBN cord-018437-yjvwa1ot 141 8 . . . cord-018437-yjvwa1ot 142 1 Flaviviridae Flaviviridae NNP cord-018437-yjvwa1ot 142 2 : : : cord-018437-yjvwa1ot 143 1 Flaviviruses flavivirus NNS cord-018437-yjvwa1ot 143 2 may may MD cord-018437-yjvwa1ot 143 3 cause cause VB cord-018437-yjvwa1ot 143 4 several several JJ cord-018437-yjvwa1ot 143 5 hemorrhagic hemorrhagic JJ cord-018437-yjvwa1ot 143 6 fever fever NN cord-018437-yjvwa1ot 143 7 syndromes syndrome NNS cord-018437-yjvwa1ot 143 8 . . . cord-018437-yjvwa1ot 144 1 Hepatitis Hepatitis NNP cord-018437-yjvwa1ot 144 2 C C NNP cord-018437-yjvwa1ot 144 3 virus virus NN cord-018437-yjvwa1ot 144 4 is be VBZ cord-018437-yjvwa1ot 144 5 also also RB cord-018437-yjvwa1ot 144 6 a a DT cord-018437-yjvwa1ot 144 7 fl fl NNP cord-018437-yjvwa1ot 144 8 avivirus avivirus NNP cord-018437-yjvwa1ot 144 9 species specie NNS cord-018437-yjvwa1ot 144 10 . . . cord-018437-yjvwa1ot 145 1 Flaviviruses flavivirus NNS cord-018437-yjvwa1ot 145 2 are be VBP cord-018437-yjvwa1ot 145 3 surrounded surround VBN cord-018437-yjvwa1ot 145 4 by by IN cord-018437-yjvwa1ot 145 5 an an DT cord-018437-yjvwa1ot 145 6 envelope envelope NN cord-018437-yjvwa1ot 145 7 studded stud VBN cord-018437-yjvwa1ot 145 8 with with IN cord-018437-yjvwa1ot 145 9 dimers dimer NNS cord-018437-yjvwa1ot 145 10 of of IN cord-018437-yjvwa1ot 145 11 viral viral JJ cord-018437-yjvwa1ot 145 12 E e NN cord-018437-yjvwa1ot 145 13 glycoprotein glycoprotein NN cord-018437-yjvwa1ot 145 14 and and CC cord-018437-yjvwa1ot 145 15 M M NNP cord-018437-yjvwa1ot 145 16 protein protein NN cord-018437-yjvwa1ot 145 17 which which WDT cord-018437-yjvwa1ot 145 18 give give VBP cord-018437-yjvwa1ot 145 19 the the DT cord-018437-yjvwa1ot 145 20 mature mature JJ cord-018437-yjvwa1ot 145 21 virion virion NN cord-018437-yjvwa1ot 145 22 a a DT cord-018437-yjvwa1ot 145 23 herringbone herringbone NN cord-018437-yjvwa1ot 145 24 appearance appearance NN cord-018437-yjvwa1ot 145 25 with with IN cord-018437-yjvwa1ot 145 26 icosahedral icosahedral JJ cord-018437-yjvwa1ot 145 27 symmetry symmetry NN cord-018437-yjvwa1ot 145 28 . . . cord-018437-yjvwa1ot 146 1 The the DT cord-018437-yjvwa1ot 146 2 genome genome NN cord-018437-yjvwa1ot 146 3 consists consist VBZ cord-018437-yjvwa1ot 146 4 of of IN cord-018437-yjvwa1ot 146 5 a a DT cord-018437-yjvwa1ot 146 6 single single JJ cord-018437-yjvwa1ot 146 7 segment segment NN cord-018437-yjvwa1ot 146 8 of of IN cord-018437-yjvwa1ot 146 9 positive positive JJ cord-018437-yjvwa1ot 146 10 - - HYPH cord-018437-yjvwa1ot 146 11 sense sense NN cord-018437-yjvwa1ot 146 12 ssRNA ssrna NN cord-018437-yjvwa1ot 147 1 ( ( -LRB- cord-018437-yjvwa1ot 147 2 Chambers Chambers NNP cord-018437-yjvwa1ot 147 3 et et NNP cord-018437-yjvwa1ot 147 4 al al NNP cord-018437-yjvwa1ot 147 5 . . NNP cord-018437-yjvwa1ot 147 6 1990 1990 CD cord-018437-yjvwa1ot 147 7 ; ; : cord-018437-yjvwa1ot 147 8 Osatomi Osatomi NNP cord-018437-yjvwa1ot 147 9 and and CC cord-018437-yjvwa1ot 147 10 Sumiyoshi Sumiyoshi NNP cord-018437-yjvwa1ot 147 11 1990 1990 CD cord-018437-yjvwa1ot 147 12 ) ) -RRB- cord-018437-yjvwa1ot 147 13 . . . cord-018437-yjvwa1ot 148 1 Cyclization cyclization NN cord-018437-yjvwa1ot 148 2 of of IN cord-018437-yjvwa1ot 148 3 the the DT cord-018437-yjvwa1ot 148 4 genome genome NN cord-018437-yjvwa1ot 148 5 , , , cord-018437-yjvwa1ot 148 6 through through IN cord-018437-yjvwa1ot 148 7 hybridization hybridization NN cord-018437-yjvwa1ot 148 8 of of IN cord-018437-yjvwa1ot 148 9 RNA RNA NNP cord-018437-yjvwa1ot 148 10 sequences sequence NNS cord-018437-yjvwa1ot 148 11 of of IN cord-018437-yjvwa1ot 148 12 the the DT cord-018437-yjvwa1ot 148 13 5′ 5′ CD cord-018437-yjvwa1ot 148 14 and and CC cord-018437-yjvwa1ot 148 15 3′ 3′ CD cord-018437-yjvwa1ot 148 16 ends end NNS cord-018437-yjvwa1ot 148 17 of of IN cord-018437-yjvwa1ot 148 18 the the DT cord-018437-yjvwa1ot 148 19 genome genome NN cord-018437-yjvwa1ot 148 20 , , , cord-018437-yjvwa1ot 148 21 may may MD cord-018437-yjvwa1ot 148 22 be be VB cord-018437-yjvwa1ot 148 23 required require VBN cord-018437-yjvwa1ot 148 24 for for IN cord-018437-yjvwa1ot 148 25 mRNA mRNA NNP cord-018437-yjvwa1ot 148 26 synthesis synthesis NN cord-018437-yjvwa1ot 148 27 ( ( -LRB- cord-018437-yjvwa1ot 148 28 Alvarez Alvarez NNP cord-018437-yjvwa1ot 148 29 et et NNP cord-018437-yjvwa1ot 148 30 al al NNP cord-018437-yjvwa1ot 148 31 . . NNP cord-018437-yjvwa1ot 148 32 2005 2005 CD cord-018437-yjvwa1ot 148 33 ) ) -RRB- cord-018437-yjvwa1ot 148 34 . . . cord-018437-yjvwa1ot 149 1 There there EX cord-018437-yjvwa1ot 149 2 is be VBZ cord-018437-yjvwa1ot 149 3 a a DT cord-018437-yjvwa1ot 149 4 long long JJ cord-018437-yjvwa1ot 149 5 open open JJ cord-018437-yjvwa1ot 149 6 reading reading NN cord-018437-yjvwa1ot 149 7 frame frame NN cord-018437-yjvwa1ot 149 8 that that WDT cord-018437-yjvwa1ot 149 9 codes code NNS cord-018437-yjvwa1ot 149 10 for for IN cord-018437-yjvwa1ot 149 11 three three CD cord-018437-yjvwa1ot 149 12 structural structural JJ cord-018437-yjvwa1ot 149 13 proteins protein NNS cord-018437-yjvwa1ot 149 14 at at IN cord-018437-yjvwa1ot 149 15 the the DT cord-018437-yjvwa1ot 149 16 5′ 5′ CD cord-018437-yjvwa1ot 149 17 end end NN cord-018437-yjvwa1ot 149 18 ; ; : cord-018437-yjvwa1ot 149 19 downstream downstream RB cord-018437-yjvwa1ot 149 20 of of IN cord-018437-yjvwa1ot 149 21 this this DT cord-018437-yjvwa1ot 149 22 region region NN cord-018437-yjvwa1ot 149 23 are be VBP cord-018437-yjvwa1ot 149 24 genes gene NNS cord-018437-yjvwa1ot 149 25 for for IN cord-018437-yjvwa1ot 149 26 seven seven CD cord-018437-yjvwa1ot 149 27 nonstructural nonstructural JJ cord-018437-yjvwa1ot 149 28 proteins protein NNS cord-018437-yjvwa1ot 149 29 ( ( -LRB- cord-018437-yjvwa1ot 149 30 Thurner Thurner NNP cord-018437-yjvwa1ot 149 31 et et NNP cord-018437-yjvwa1ot 149 32 al al NNP cord-018437-yjvwa1ot 149 33 . . . cord-018437-yjvwa1ot 149 34 2004 2004 CD cord-018437-yjvwa1ot 149 35 ) ) -RRB- cord-018437-yjvwa1ot 149 36 . . . cord-018437-yjvwa1ot 150 1 The the DT cord-018437-yjvwa1ot 150 2 positive positive JJ cord-018437-yjvwa1ot 150 3 - - HYPH cord-018437-yjvwa1ot 150 4 sense sense NN cord-018437-yjvwa1ot 150 5 genome genome NN cord-018437-yjvwa1ot 150 6 is be VBZ cord-018437-yjvwa1ot 150 7 directly directly RB cord-018437-yjvwa1ot 150 8 translated translate VBN cord-018437-yjvwa1ot 150 9 into into IN cord-018437-yjvwa1ot 150 10 a a DT cord-018437-yjvwa1ot 150 11 large large JJ cord-018437-yjvwa1ot 150 12 polyprotein polyprotein NN cord-018437-yjvwa1ot 150 13 , , , cord-018437-yjvwa1ot 150 14 which which WDT cord-018437-yjvwa1ot 150 15 undergoes undergo VBZ cord-018437-yjvwa1ot 150 16 intra intra JJ cord-018437-yjvwa1ot 150 17 - - JJ cord-018437-yjvwa1ot 150 18 and and CC cord-018437-yjvwa1ot 150 19 post post JJ cord-018437-yjvwa1ot 150 20 - - JJ cord-018437-yjvwa1ot 150 21 translational translational JJ cord-018437-yjvwa1ot 150 22 cleavage cleavage NN cord-018437-yjvwa1ot 150 23 . . . cord-018437-yjvwa1ot 151 1 Strain strain VB cord-018437-yjvwa1ot 151 2 evolution evolution NN cord-018437-yjvwa1ot 151 3 and and CC cord-018437-yjvwa1ot 151 4 clinical clinical JJ cord-018437-yjvwa1ot 151 5 diversity diversity NN cord-018437-yjvwa1ot 151 6 have have VBP cord-018437-yjvwa1ot 151 7 been be VBN cord-018437-yjvwa1ot 151 8 driven drive VBN cord-018437-yjvwa1ot 151 9 by by IN cord-018437-yjvwa1ot 151 10 a a DT cord-018437-yjvwa1ot 151 11 high high JJ cord-018437-yjvwa1ot 151 12 rate rate NN cord-018437-yjvwa1ot 151 13 of of IN cord-018437-yjvwa1ot 151 14 mutation mutation NN cord-018437-yjvwa1ot 151 15 at at IN cord-018437-yjvwa1ot 151 16 replication replication NN cord-018437-yjvwa1ot 151 17 and and CC cord-018437-yjvwa1ot 151 18 through through IN cord-018437-yjvwa1ot 151 19 molecular molecular JJ cord-018437-yjvwa1ot 151 20 recombination recombination NN cord-018437-yjvwa1ot 151 21 . . . cord-018437-yjvwa1ot 152 1 The the DT cord-018437-yjvwa1ot 152 2 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 152 3 is be VBZ cord-018437-yjvwa1ot 152 4 formed form VBN cord-018437-yjvwa1ot 152 5 by by IN cord-018437-yjvwa1ot 152 6 interaction interaction NN cord-018437-yjvwa1ot 152 7 of of IN cord-018437-yjvwa1ot 152 8 genomic genomic JJ cord-018437-yjvwa1ot 152 9 RNA RNA NNP cord-018437-yjvwa1ot 152 10 with with IN cord-018437-yjvwa1ot 152 11 capsid capsid NN cord-018437-yjvwa1ot 152 12 proteins protein NNS cord-018437-yjvwa1ot 152 13 . . . cord-018437-yjvwa1ot 153 1 The the DT cord-018437-yjvwa1ot 153 2 complete complete JJ cord-018437-yjvwa1ot 153 3 virion virion NN cord-018437-yjvwa1ot 153 4 has have VBZ cord-018437-yjvwa1ot 153 5 a a DT cord-018437-yjvwa1ot 153 6 spherical spherical JJ cord-018437-yjvwa1ot 153 7 morphology morphology NN cord-018437-yjvwa1ot 153 8 approximately approximately RB cord-018437-yjvwa1ot 153 9 50 50 CD cord-018437-yjvwa1ot 153 10 nm nm NN cord-018437-yjvwa1ot 153 11 in in IN cord-018437-yjvwa1ot 153 12 diameter diameter NN cord-018437-yjvwa1ot 153 13 . . . cord-018437-yjvwa1ot 154 1 This this DT cord-018437-yjvwa1ot 154 2 family family NN cord-018437-yjvwa1ot 154 3 of of IN cord-018437-yjvwa1ot 154 4 viruses virus NNS cord-018437-yjvwa1ot 154 5 is be VBZ cord-018437-yjvwa1ot 154 6 not not RB cord-018437-yjvwa1ot 154 7 assigned assign VBN cord-018437-yjvwa1ot 154 8 to to IN cord-018437-yjvwa1ot 154 9 an an DT cord-018437-yjvwa1ot 154 10 order order NN cord-018437-yjvwa1ot 154 11 . . . cord-018437-yjvwa1ot 155 1 There there EX cord-018437-yjvwa1ot 155 2 are be VBP cord-018437-yjvwa1ot 155 3 four four CD cord-018437-yjvwa1ot 155 4 genera genus NNS cord-018437-yjvwa1ot 155 5 within within IN cord-018437-yjvwa1ot 155 6 the the DT cord-018437-yjvwa1ot 155 7 family family NN cord-018437-yjvwa1ot 155 8 Flaviviridae Flaviviridae NNP cord-018437-yjvwa1ot 155 9 . . . cord-018437-yjvwa1ot 156 1 Within within IN cord-018437-yjvwa1ot 156 2 the the DT cord-018437-yjvwa1ot 156 3 genus genus JJ cord-018437-yjvwa1ot 156 4 Flavivirus Flavivirus NNP cord-018437-yjvwa1ot 156 5 , , , cord-018437-yjvwa1ot 156 6 there there EX cord-018437-yjvwa1ot 156 7 are be VBP cord-018437-yjvwa1ot 156 8 53 53 CD cord-018437-yjvwa1ot 156 9 species specie NNS cord-018437-yjvwa1ot 156 10 , , , cord-018437-yjvwa1ot 156 11 including include VBG cord-018437-yjvwa1ot 156 12 Dengue dengue NN cord-018437-yjvwa1ot 156 13 virus virus NN cord-018437-yjvwa1ot 156 14 ( ( -LRB- cord-018437-yjvwa1ot 156 15 Simmons Simmons NNP cord-018437-yjvwa1ot 156 16 et et NNP cord-018437-yjvwa1ot 156 17 al al NNP cord-018437-yjvwa1ot 156 18 . . . cord-018437-yjvwa1ot 157 1 2012 2012 CD cord-018437-yjvwa1ot 157 2 Hepatitis Hepatitis NNP cord-018437-yjvwa1ot 157 3 C C NNP cord-018437-yjvwa1ot 157 4 virus virus NN cord-018437-yjvwa1ot 157 5 ( ( -LRB- cord-018437-yjvwa1ot 157 6 HCV HCV NNP cord-018437-yjvwa1ot 157 7 ) ) -RRB- cord-018437-yjvwa1ot 157 8 is be VBZ cord-018437-yjvwa1ot 157 9 the the DT cord-018437-yjvwa1ot 157 10 type type NN cord-018437-yjvwa1ot 157 11 species specie NNS cord-018437-yjvwa1ot 157 12 of of IN cord-018437-yjvwa1ot 157 13 the the DT cord-018437-yjvwa1ot 157 14 genus genus NN cord-018437-yjvwa1ot 157 15 Hepacivirus Hepacivirus NNP cord-018437-yjvwa1ot 157 16 in in IN cord-018437-yjvwa1ot 157 17 the the DT cord-018437-yjvwa1ot 157 18 family family NN cord-018437-yjvwa1ot 157 19 Flaviviridae Flaviviridae NNP cord-018437-yjvwa1ot 157 20 . . . cord-018437-yjvwa1ot 158 1 The the DT cord-018437-yjvwa1ot 158 2 physical physical JJ cord-018437-yjvwa1ot 158 3 properties property NNS cord-018437-yjvwa1ot 158 4 of of IN cord-018437-yjvwa1ot 158 5 HCV HCV NNP cord-018437-yjvwa1ot 158 6 have have VBP cord-018437-yjvwa1ot 158 7 not not RB cord-018437-yjvwa1ot 158 8 been be VBN cord-018437-yjvwa1ot 158 9 as as RB cord-018437-yjvwa1ot 158 10 well well RB cord-018437-yjvwa1ot 158 11 defi defi NNP cord-018437-yjvwa1ot 158 12 ned ned NNP cord-018437-yjvwa1ot 158 13 as as IN cord-018437-yjvwa1ot 158 14 other other JJ cord-018437-yjvwa1ot 158 15 fl fl NNP cord-018437-yjvwa1ot 158 16 aviviruses aviviruse NNS cord-018437-yjvwa1ot 158 17 because because IN cord-018437-yjvwa1ot 158 18 there there EX cord-018437-yjvwa1ot 158 19 is be VBZ cord-018437-yjvwa1ot 158 20 no no DT cord-018437-yjvwa1ot 158 21 effi effi NNP cord-018437-yjvwa1ot 158 22 cient cient NN cord-018437-yjvwa1ot 158 23 method method NN cord-018437-yjvwa1ot 158 24 for for IN cord-018437-yjvwa1ot 158 25 in in IN cord-018437-yjvwa1ot 158 26 vitro vitro FW cord-018437-yjvwa1ot 158 27 replication replication NN cord-018437-yjvwa1ot 158 28 of of IN cord-018437-yjvwa1ot 158 29 HCV HCV NNP cord-018437-yjvwa1ot 158 30 . . . cord-018437-yjvwa1ot 159 1 Virion virion NN cord-018437-yjvwa1ot 159 2 morphology morphology NN cord-018437-yjvwa1ot 159 3 is be VBZ cord-018437-yjvwa1ot 159 4 consistent consistent JJ cord-018437-yjvwa1ot 159 5 with with IN cord-018437-yjvwa1ot 159 6 other other JJ cord-018437-yjvwa1ot 159 7 fl fl NNP cord-018437-yjvwa1ot 159 8 aviviruses aviviruse NNS cord-018437-yjvwa1ot 159 9 ; ; : cord-018437-yjvwa1ot 159 10 complete complete JJ cord-018437-yjvwa1ot 159 11 , , , cord-018437-yjvwa1ot 159 12 enveloped enveloped JJ cord-018437-yjvwa1ot 159 13 virions virion NNS cord-018437-yjvwa1ot 159 14 have have VBP cord-018437-yjvwa1ot 159 15 a a DT cord-018437-yjvwa1ot 159 16 diameter diameter NN cord-018437-yjvwa1ot 159 17 of of IN cord-018437-yjvwa1ot 159 18 55 55 CD cord-018437-yjvwa1ot 159 19 - - SYM cord-018437-yjvwa1ot 159 20 65 65 CD cord-018437-yjvwa1ot 159 21 nm nm NN cord-018437-yjvwa1ot 159 22 . . . cord-018437-yjvwa1ot 160 1 The the DT cord-018437-yjvwa1ot 160 2 single single JJ cord-018437-yjvwa1ot 160 3 segment segment NN cord-018437-yjvwa1ot 160 4 positive positive JJ cord-018437-yjvwa1ot 160 5 - - HYPH cord-018437-yjvwa1ot 160 6 sense sense NN cord-018437-yjvwa1ot 160 7 ssRNA ssrna NN cord-018437-yjvwa1ot 160 8 is be VBZ cord-018437-yjvwa1ot 160 9 ~9.6 ~9.6 CD cord-018437-yjvwa1ot 160 10 kb kb NNP cord-018437-yjvwa1ot 160 11 in in IN cord-018437-yjvwa1ot 160 12 length length NN cord-018437-yjvwa1ot 161 1 ( ( -LRB- cord-018437-yjvwa1ot 161 2 Hijikata Hijikata NNP cord-018437-yjvwa1ot 161 3 et et NNP cord-018437-yjvwa1ot 161 4 al al NNP cord-018437-yjvwa1ot 161 5 . . NNP cord-018437-yjvwa1ot 161 6 1991 1991 CD cord-018437-yjvwa1ot 161 7 ) ) -RRB- cord-018437-yjvwa1ot 161 8 . . . cord-018437-yjvwa1ot 162 1 A a DT cord-018437-yjvwa1ot 162 2 single single JJ cord-018437-yjvwa1ot 162 3 open open JJ cord-018437-yjvwa1ot 162 4 reading reading NN cord-018437-yjvwa1ot 162 5 frame frame NN cord-018437-yjvwa1ot 162 6 is be VBZ cord-018437-yjvwa1ot 162 7 fl fl NNP cord-018437-yjvwa1ot 162 8 anked anke VBN cord-018437-yjvwa1ot 162 9 by by IN cord-018437-yjvwa1ot 162 10 highly highly RB cord-018437-yjvwa1ot 162 11 conserved conserve VBN cord-018437-yjvwa1ot 162 12 regions region NNS cord-018437-yjvwa1ot 162 13 at at IN cord-018437-yjvwa1ot 162 14 the the DT cord-018437-yjvwa1ot 162 15 5′ 5′ CD cord-018437-yjvwa1ot 162 16 and and CC cord-018437-yjvwa1ot 162 17 3′ 3′ CD cord-018437-yjvwa1ot 162 18 ends end NNS cord-018437-yjvwa1ot 162 19 . . . cord-018437-yjvwa1ot 163 1 Cap cap NN cord-018437-yjvwa1ot 163 2 - - HYPH cord-018437-yjvwa1ot 163 3 independent independent JJ cord-018437-yjvwa1ot 163 4 protein protein NN cord-018437-yjvwa1ot 163 5 synthesis synthesis NN cord-018437-yjvwa1ot 163 6 , , , cord-018437-yjvwa1ot 163 7 typical typical JJ cord-018437-yjvwa1ot 163 8 of of IN cord-018437-yjvwa1ot 163 9 Flavivirus Flavivirus NNP cord-018437-yjvwa1ot 163 10 species specie NNS cord-018437-yjvwa1ot 163 11 , , , cord-018437-yjvwa1ot 163 12 is be VBZ cord-018437-yjvwa1ot 163 13 initiated initiate VBN cord-018437-yjvwa1ot 163 14 at at IN cord-018437-yjvwa1ot 163 15 an an DT cord-018437-yjvwa1ot 163 16 internal internal JJ cord-018437-yjvwa1ot 163 17 ribosomal ribosomal JJ cord-018437-yjvwa1ot 163 18 entry entry NN cord-018437-yjvwa1ot 163 19 site site NN cord-018437-yjvwa1ot 163 20 ( ( -LRB- cord-018437-yjvwa1ot 163 21 IRES IRES NNP cord-018437-yjvwa1ot 163 22 ) ) -RRB- cord-018437-yjvwa1ot 163 23 within within IN cord-018437-yjvwa1ot 163 24 the the DT cord-018437-yjvwa1ot 163 25 5′ 5′ CD cord-018437-yjvwa1ot 163 26 untranslated untranslated JJ cord-018437-yjvwa1ot 163 27 region region NN cord-018437-yjvwa1ot 163 28 . . . cord-018437-yjvwa1ot 164 1 This this DT cord-018437-yjvwa1ot 164 2 results result VBZ cord-018437-yjvwa1ot 164 3 in in IN cord-018437-yjvwa1ot 164 4 synthesis synthesis NN cord-018437-yjvwa1ot 164 5 of of IN cord-018437-yjvwa1ot 164 6 a a DT cord-018437-yjvwa1ot 164 7 polyprotein polyprotein NN cord-018437-yjvwa1ot 164 8 that that WDT cord-018437-yjvwa1ot 164 9 undergoes undergo VBZ cord-018437-yjvwa1ot 164 10 cleavage cleavage NN cord-018437-yjvwa1ot 164 11 and and CC cord-018437-yjvwa1ot 164 12 further further JJ cord-018437-yjvwa1ot 164 13 processing processing NN cord-018437-yjvwa1ot 164 14 during during IN cord-018437-yjvwa1ot 164 15 and and CC cord-018437-yjvwa1ot 164 16 after after IN cord-018437-yjvwa1ot 164 17 translation translation NN cord-018437-yjvwa1ot 164 18 . . . cord-018437-yjvwa1ot 165 1 A a DT cord-018437-yjvwa1ot 165 2 unique unique JJ cord-018437-yjvwa1ot 165 3 and and CC cord-018437-yjvwa1ot 165 4 highly highly RB cord-018437-yjvwa1ot 165 5 conserved conserve VBN cord-018437-yjvwa1ot 165 6 sequence sequence NN cord-018437-yjvwa1ot 165 7 upstream upstream RB cord-018437-yjvwa1ot 165 8 of of IN cord-018437-yjvwa1ot 165 9 the the DT cord-018437-yjvwa1ot 165 10 IRES IRES NNP cord-018437-yjvwa1ot 165 11 interacts interact VBZ cord-018437-yjvwa1ot 165 12 with with IN cord-018437-yjvwa1ot 165 13 liver liver NN cord-018437-yjvwa1ot 165 14 - - HYPH cord-018437-yjvwa1ot 165 15 specifi specifi NNP cord-018437-yjvwa1ot 165 16 c c NNP cord-018437-yjvwa1ot 165 17 microRNA microRNA NNP cord-018437-yjvwa1ot 165 18 and and CC cord-018437-yjvwa1ot 165 19 is be VBZ cord-018437-yjvwa1ot 165 20 required require VBN cord-018437-yjvwa1ot 165 21 for for IN cord-018437-yjvwa1ot 165 22 effi effi NNP cord-018437-yjvwa1ot 165 23 cient cient NNP cord-018437-yjvwa1ot 165 24 replication replication NN cord-018437-yjvwa1ot 165 25 . . . cord-018437-yjvwa1ot 166 1 Circulating circulate VBG cord-018437-yjvwa1ot 166 2 HCV HCV NNP cord-018437-yjvwa1ot 166 3 is be VBZ cord-018437-yjvwa1ot 166 4 associated associate VBN cord-018437-yjvwa1ot 166 5 with with IN cord-018437-yjvwa1ot 166 6 host host NN cord-018437-yjvwa1ot 166 7 LDL ldl NN cord-018437-yjvwa1ot 166 8 / / SYM cord-018437-yjvwa1ot 166 9 VLDL VLDL NNP cord-018437-yjvwa1ot 166 10 , , , cord-018437-yjvwa1ot 166 11 which which WDT cord-018437-yjvwa1ot 166 12 may may MD cord-018437-yjvwa1ot 166 13 play play VB cord-018437-yjvwa1ot 166 14 a a DT cord-018437-yjvwa1ot 166 15 role role NN cord-018437-yjvwa1ot 166 16 in in IN cord-018437-yjvwa1ot 166 17 delivery delivery NN cord-018437-yjvwa1ot 166 18 of of IN cord-018437-yjvwa1ot 166 19 virions virion NNS cord-018437-yjvwa1ot 166 20 to to IN cord-018437-yjvwa1ot 166 21 hepatocytes hepatocyte NNS cord-018437-yjvwa1ot 166 22 . . . cord-018437-yjvwa1ot 167 1 The the DT cord-018437-yjvwa1ot 167 2 error error NN cord-018437-yjvwa1ot 167 3 - - HYPH cord-018437-yjvwa1ot 167 4 prone prone JJ cord-018437-yjvwa1ot 167 5 RNA rna NN cord-018437-yjvwa1ot 167 6 polymerase polymerase NN cord-018437-yjvwa1ot 167 7 and and CC cord-018437-yjvwa1ot 167 8 high high JJ cord-018437-yjvwa1ot 167 9 replication replication NN cord-018437-yjvwa1ot 167 10 rate rate NN cord-018437-yjvwa1ot 167 11 of of IN cord-018437-yjvwa1ot 167 12 HCV HCV NNP cord-018437-yjvwa1ot 167 13 has have VBZ cord-018437-yjvwa1ot 167 14 resulted result VBN cord-018437-yjvwa1ot 167 15 in in IN cord-018437-yjvwa1ot 167 16 a a DT cord-018437-yjvwa1ot 167 17 great great JJ cord-018437-yjvwa1ot 167 18 genetic genetic JJ cord-018437-yjvwa1ot 167 19 diversity diversity NN cord-018437-yjvwa1ot 167 20 and and CC cord-018437-yjvwa1ot 167 21 heterogeneity heterogeneity NN cord-018437-yjvwa1ot 167 22 of of IN cord-018437-yjvwa1ot 167 23 clinical clinical JJ cord-018437-yjvwa1ot 167 24 isolates isolate NNS cord-018437-yjvwa1ot 167 25 . . . cord-018437-yjvwa1ot 168 1 HCV HCV NNP cord-018437-yjvwa1ot 168 2 isolates isolate NNS cord-018437-yjvwa1ot 168 3 can can MD cord-018437-yjvwa1ot 168 4 be be VB cord-018437-yjvwa1ot 168 5 grouped group VBN cord-018437-yjvwa1ot 168 6 by by IN cord-018437-yjvwa1ot 168 7 genotypic genotypic JJ cord-018437-yjvwa1ot 168 8 analysis analysis NN cord-018437-yjvwa1ot 168 9 into into IN cord-018437-yjvwa1ot 168 10 six six CD cord-018437-yjvwa1ot 168 11 groups group NNS cord-018437-yjvwa1ot 168 12 and and CC cord-018437-yjvwa1ot 168 13 many many JJ cord-018437-yjvwa1ot 168 14 subgroups subgroup NNS cord-018437-yjvwa1ot 168 15 . . . cord-018437-yjvwa1ot 169 1 There there EX cord-018437-yjvwa1ot 169 2 are be VBP cord-018437-yjvwa1ot 169 3 differences difference NNS cord-018437-yjvwa1ot 169 4 with with IN cord-018437-yjvwa1ot 169 5 respect respect NN cord-018437-yjvwa1ot 169 6 to to IN cord-018437-yjvwa1ot 169 7 responses response NNS cord-018437-yjvwa1ot 169 8 to to IN cord-018437-yjvwa1ot 169 9 antiviral antiviral JJ cord-018437-yjvwa1ot 169 10 therapy therapy NN cord-018437-yjvwa1ot 169 11 among among IN cord-018437-yjvwa1ot 169 12 the the DT cord-018437-yjvwa1ot 169 13 genotypes genotype NNS cord-018437-yjvwa1ot 169 14 , , , cord-018437-yjvwa1ot 169 15 but but CC cord-018437-yjvwa1ot 169 16 intrinsic intrinsic JJ cord-018437-yjvwa1ot 169 17 virulence virulence NN cord-018437-yjvwa1ot 169 18 is be VBZ cord-018437-yjvwa1ot 169 19 similar similar JJ cord-018437-yjvwa1ot 169 20 . . . cord-018437-yjvwa1ot 170 1 The the DT cord-018437-yjvwa1ot 170 2 vast vast JJ cord-018437-yjvwa1ot 170 3 majority majority NN cord-018437-yjvwa1ot 170 4 of of IN cord-018437-yjvwa1ot 170 5 strains strain NNS cord-018437-yjvwa1ot 170 6 in in IN cord-018437-yjvwa1ot 170 7 the the DT cord-018437-yjvwa1ot 170 8 United United NNP cord-018437-yjvwa1ot 170 9 States States NNP cord-018437-yjvwa1ot 170 10 are be VBP cord-018437-yjvwa1ot 170 11 genotypes genotype NNS cord-018437-yjvwa1ot 170 12 1a 1a CD cord-018437-yjvwa1ot 170 13 , , , cord-018437-yjvwa1ot 170 14 1b 1b CD cord-018437-yjvwa1ot 170 15 , , , cord-018437-yjvwa1ot 170 16 and and CC cord-018437-yjvwa1ot 170 17 2 2 CD cord-018437-yjvwa1ot 170 18 , , , cord-018437-yjvwa1ot 170 19 whereas whereas IN cord-018437-yjvwa1ot 170 20 Central central JJ cord-018437-yjvwa1ot 170 21 African african JJ cord-018437-yjvwa1ot 170 22 strains strain NNS cord-018437-yjvwa1ot 170 23 are be VBP cord-018437-yjvwa1ot 170 24 almost almost RB cord-018437-yjvwa1ot 170 25 exclusively exclusively RB cord-018437-yjvwa1ot 170 26 genotype genotype NN cord-018437-yjvwa1ot 170 27 4 4 CD cord-018437-yjvwa1ot 170 28 . . . cord-018437-yjvwa1ot 171 1 Hemorrhagic Hemorrhagic NNP cord-018437-yjvwa1ot 171 2 Fever Fever NNP cord-018437-yjvwa1ot 171 3 ( ( -LRB- cord-018437-yjvwa1ot 171 4 HF HF NNP cord-018437-yjvwa1ot 171 5 ) ) -RRB- cord-018437-yjvwa1ot 171 6 Syndromes syndrome NNS cord-018437-yjvwa1ot 171 7 : : : cord-018437-yjvwa1ot 172 1 Viral viral JJ cord-018437-yjvwa1ot 172 2 hemorrhagic hemorrhagic JJ cord-018437-yjvwa1ot 172 3 fever fever NN cord-018437-yjvwa1ot 172 4 syndromes syndrome NNS cord-018437-yjvwa1ot 172 5 may may MD cord-018437-yjvwa1ot 172 6 be be VB cord-018437-yjvwa1ot 172 7 caused cause VBN cord-018437-yjvwa1ot 172 8 by by IN cord-018437-yjvwa1ot 172 9 many many JJ cord-018437-yjvwa1ot 172 10 species specie NNS cord-018437-yjvwa1ot 172 11 of of IN cord-018437-yjvwa1ot 172 12 viruses virus NNS cord-018437-yjvwa1ot 172 13 from from IN cord-018437-yjvwa1ot 172 14 four four CD cord-018437-yjvwa1ot 172 15 different different JJ cord-018437-yjvwa1ot 172 16 families family NNS cord-018437-yjvwa1ot 172 17 : : : cord-018437-yjvwa1ot 172 18 Arenaviridae Arenaviridae NNP cord-018437-yjvwa1ot 172 19 , , , cord-018437-yjvwa1ot 172 20 Bunyaviridae Bunyaviridae NNP cord-018437-yjvwa1ot 172 21 , , , cord-018437-yjvwa1ot 172 22 Flaviviridae Flaviviridae NNP cord-018437-yjvwa1ot 172 23 and and CC cord-018437-yjvwa1ot 172 24 Filoviridae Filoviridae NNP cord-018437-yjvwa1ot 172 25 ; ; : cord-018437-yjvwa1ot 172 26 all all DT cord-018437-yjvwa1ot 172 27 are be VBP cord-018437-yjvwa1ot 172 28 single single RB cord-018437-yjvwa1ot 172 29 - - HYPH cord-018437-yjvwa1ot 172 30 stranded strand VBN cord-018437-yjvwa1ot 172 31 RNA RNA NNP cord-018437-yjvwa1ot 172 32 viruses virus NNS cord-018437-yjvwa1ot 172 33 . . . cord-018437-yjvwa1ot 173 1 See see VB cord-018437-yjvwa1ot 173 2 the the DT cord-018437-yjvwa1ot 173 3 discussions discussion NNS cord-018437-yjvwa1ot 173 4 above above IN cord-018437-yjvwa1ot 173 5 for for IN cord-018437-yjvwa1ot 173 6 specifi specifi NNP cord-018437-yjvwa1ot 173 7 c c NN cord-018437-yjvwa1ot 173 8 information information NN cord-018437-yjvwa1ot 173 9 related relate VBN cord-018437-yjvwa1ot 173 10 to to IN cord-018437-yjvwa1ot 173 11 these these DT cord-018437-yjvwa1ot 173 12 virus virus NN cord-018437-yjvwa1ot 173 13 families family NNS cord-018437-yjvwa1ot 173 14 . . . cord-018437-yjvwa1ot 174 1 Typical typical JJ cord-018437-yjvwa1ot 174 2 symptoms symptom NNS cord-018437-yjvwa1ot 174 3 of of IN cord-018437-yjvwa1ot 174 4 viral viral JJ cord-018437-yjvwa1ot 174 5 hemorrhagic hemorrhagic JJ cord-018437-yjvwa1ot 174 6 fever fever NN cord-018437-yjvwa1ot 174 7 infection infection NN cord-018437-yjvwa1ot 174 8 include include VBP cord-018437-yjvwa1ot 174 9 fever fever NN cord-018437-yjvwa1ot 174 10 , , , cord-018437-yjvwa1ot 174 11 malaise malaise NN cord-018437-yjvwa1ot 174 12 , , , cord-018437-yjvwa1ot 174 13 hypotension hypotension NN cord-018437-yjvwa1ot 174 14 , , , cord-018437-yjvwa1ot 174 15 and and CC cord-018437-yjvwa1ot 174 16 coagulation coagulation NN cord-018437-yjvwa1ot 174 17 defects defect NNS cord-018437-yjvwa1ot 174 18 . . . cord-018437-yjvwa1ot 175 1 With with IN cord-018437-yjvwa1ot 175 2 the the DT cord-018437-yjvwa1ot 175 3 exception exception NN cord-018437-yjvwa1ot 175 4 of of IN cord-018437-yjvwa1ot 175 5 dengue dengue NN cord-018437-yjvwa1ot 175 6 , , , cord-018437-yjvwa1ot 175 7 the the DT cord-018437-yjvwa1ot 175 8 other other JJ cord-018437-yjvwa1ot 175 9 HF HF NNP cord-018437-yjvwa1ot 175 10 viral viral JJ cord-018437-yjvwa1ot 175 11 agents agent NNS cord-018437-yjvwa1ot 175 12 are be VBP cord-018437-yjvwa1ot 175 13 maintained maintain VBN cord-018437-yjvwa1ot 175 14 in in IN cord-018437-yjvwa1ot 175 15 nonhuman nonhuman NN cord-018437-yjvwa1ot 175 16 vertebrate vertebrate JJ cord-018437-yjvwa1ot 175 17 hosts host NNS cord-018437-yjvwa1ot 175 18 ; ; : cord-018437-yjvwa1ot 175 19 humans human NNS cord-018437-yjvwa1ot 175 20 are be VBP cord-018437-yjvwa1ot 175 21 coincidental coincidental JJ cord-018437-yjvwa1ot 175 22 , , , cord-018437-yjvwa1ot 175 23 dead dead JJ cord-018437-yjvwa1ot 175 24 - - HYPH cord-018437-yjvwa1ot 175 25 end end NN cord-018437-yjvwa1ot 175 26 hosts host NNS cord-018437-yjvwa1ot 175 27 . . . cord-018437-yjvwa1ot 176 1 In in IN cord-018437-yjvwa1ot 176 2 dengue dengue NN cord-018437-yjvwa1ot 176 3 , , , cord-018437-yjvwa1ot 176 4 human human JJ cord-018437-yjvwa1ot 176 5 infection infection NN cord-018437-yjvwa1ot 176 6 is be VBZ cord-018437-yjvwa1ot 176 7 maintained maintain VBN cord-018437-yjvwa1ot 176 8 through through IN cord-018437-yjvwa1ot 176 9 a a DT cord-018437-yjvwa1ot 176 10 mosquito mosquito NN cord-018437-yjvwa1ot 176 11 vector vector NN cord-018437-yjvwa1ot 176 12 . . . cord-018437-yjvwa1ot 177 1 The the DT cord-018437-yjvwa1ot 177 2 epidemiologic epidemiologic JJ cord-018437-yjvwa1ot 177 3 distribution distribution NN cord-018437-yjvwa1ot 177 4 of of IN cord-018437-yjvwa1ot 177 5 disease disease NN cord-018437-yjvwa1ot 177 6 refl refl NNP cord-018437-yjvwa1ot 177 7 ects ects NNP cord-018437-yjvwa1ot 177 8 the the DT cord-018437-yjvwa1ot 177 9 geographic geographic JJ cord-018437-yjvwa1ot 177 10 range range NN cord-018437-yjvwa1ot 177 11 of of IN cord-018437-yjvwa1ot 177 12 the the DT cord-018437-yjvwa1ot 177 13 reservoir reservoir NN cord-018437-yjvwa1ot 177 14 host host NN cord-018437-yjvwa1ot 177 15 . . . cord-018437-yjvwa1ot 178 1 HF HF NNP cord-018437-yjvwa1ot 178 2 viruses virus NNS cord-018437-yjvwa1ot 178 3 primarily primarily RB cord-018437-yjvwa1ot 178 4 infect infect VBP cord-018437-yjvwa1ot 178 5 dendritic dendritic JJ cord-018437-yjvwa1ot 178 6 cells cell NNS cord-018437-yjvwa1ot 178 7 , , , cord-018437-yjvwa1ot 178 8 macrocytes macrocyte NNS cord-018437-yjvwa1ot 178 9 , , , cord-018437-yjvwa1ot 178 10 and and CC cord-018437-yjvwa1ot 178 11 monocytes monocyte NNS cord-018437-yjvwa1ot 178 12 , , , cord-018437-yjvwa1ot 178 13 which which WDT cord-018437-yjvwa1ot 178 14 are be VBP cord-018437-yjvwa1ot 178 15 present present JJ cord-018437-yjvwa1ot 178 16 in in IN cord-018437-yjvwa1ot 178 17 virtually virtually RB cord-018437-yjvwa1ot 178 18 all all DT cord-018437-yjvwa1ot 178 19 tissues tissue NNS cord-018437-yjvwa1ot 178 20 and and CC cord-018437-yjvwa1ot 178 21 organ organ NN cord-018437-yjvwa1ot 178 22 systems system NNS cord-018437-yjvwa1ot 178 23 ; ; : cord-018437-yjvwa1ot 178 24 parenchymal parenchymal NN cord-018437-yjvwa1ot 178 25 cells cell NNS cord-018437-yjvwa1ot 178 26 may may MD cord-018437-yjvwa1ot 178 27 also also RB cord-018437-yjvwa1ot 178 28 be be VB cord-018437-yjvwa1ot 178 29 susceptible susceptible JJ cord-018437-yjvwa1ot 178 30 to to IN cord-018437-yjvwa1ot 178 31 infection infection NN cord-018437-yjvwa1ot 178 32 , , , cord-018437-yjvwa1ot 178 33 depending depend VBG cord-018437-yjvwa1ot 178 34 on on IN cord-018437-yjvwa1ot 178 35 the the DT cord-018437-yjvwa1ot 178 36 virus virus NN cord-018437-yjvwa1ot 178 37 . . . cord-018437-yjvwa1ot 179 1 Infected infected JJ cord-018437-yjvwa1ot 179 2 cells cell NNS cord-018437-yjvwa1ot 179 3 release release VBP cord-018437-yjvwa1ot 179 4 mediators mediator NNS cord-018437-yjvwa1ot 179 5 that that WDT cord-018437-yjvwa1ot 179 6 result result VBP cord-018437-yjvwa1ot 179 7 in in IN cord-018437-yjvwa1ot 179 8 marked marked JJ cord-018437-yjvwa1ot 179 9 increased increased JJ cord-018437-yjvwa1ot 179 10 vascular vascular JJ cord-018437-yjvwa1ot 179 11 permeability permeability NN cord-018437-yjvwa1ot 179 12 , , , cord-018437-yjvwa1ot 179 13 compromising compromise VBG cord-018437-yjvwa1ot 179 14 the the DT cord-018437-yjvwa1ot 179 15 function function NN cord-018437-yjvwa1ot 179 16 of of IN cord-018437-yjvwa1ot 179 17 critical critical JJ cord-018437-yjvwa1ot 179 18 organ organ NN cord-018437-yjvwa1ot 179 19 systems system NNS cord-018437-yjvwa1ot 179 20 . . . cord-018437-yjvwa1ot 180 1 Suppression suppression NN cord-018437-yjvwa1ot 180 2 of of IN cord-018437-yjvwa1ot 180 3 cellular cellular JJ cord-018437-yjvwa1ot 180 4 type type NN cord-018437-yjvwa1ot 180 5 1 1 CD cord-018437-yjvwa1ot 180 6 interferon interferon NN cord-018437-yjvwa1ot 180 7 response response NN cord-018437-yjvwa1ot 180 8 is be VBZ cord-018437-yjvwa1ot 180 9 a a DT cord-018437-yjvwa1ot 180 10 signifi signifi NN cord-018437-yjvwa1ot 180 11 ca can MD cord-018437-yjvwa1ot 180 12 nt not RB cord-018437-yjvwa1ot 180 13 contributor contributor VB cord-018437-yjvwa1ot 180 14 to to IN cord-018437-yjvwa1ot 180 15 pathogenesis pathogenesis NN cord-018437-yjvwa1ot 181 1 ( ( -LRB- cord-018437-yjvwa1ot 181 2 Habjan Habjan NNP cord-018437-yjvwa1ot 181 3 et et NNP cord-018437-yjvwa1ot 181 4 al al NNP cord-018437-yjvwa1ot 181 5 . . NNP cord-018437-yjvwa1ot 181 6 2008 2008 CD cord-018437-yjvwa1ot 181 7 ) ) -RRB- cord-018437-yjvwa1ot 181 8 . . . cord-018437-yjvwa1ot 182 1 Hepadnaviridae Hepadnaviridae NNP cord-018437-yjvwa1ot 182 2 : : : cord-018437-yjvwa1ot 183 1 In in IN cord-018437-yjvwa1ot 183 2 the the DT cord-018437-yjvwa1ot 183 3 family family NN cord-018437-yjvwa1ot 183 4 Hepadnaviridae Hepadnaviridae NNP cord-018437-yjvwa1ot 183 5 , , , cord-018437-yjvwa1ot 183 6 there there EX cord-018437-yjvwa1ot 183 7 are be VBP cord-018437-yjvwa1ot 183 8 two two CD cord-018437-yjvwa1ot 183 9 genera genus NNS cord-018437-yjvwa1ot 183 10 , , , cord-018437-yjvwa1ot 183 11 Avihepadnavirus Avihepadnavirus NNP cord-018437-yjvwa1ot 183 12 ( ( -LRB- cord-018437-yjvwa1ot 183 13 two two CD cord-018437-yjvwa1ot 183 14 species specie NNS cord-018437-yjvwa1ot 183 15 ) ) -RRB- cord-018437-yjvwa1ot 183 16 and and CC cord-018437-yjvwa1ot 183 17 Orthohepadnavirus Orthohepadnavirus NNP cord-018437-yjvwa1ot 183 18 ( ( -LRB- cord-018437-yjvwa1ot 183 19 four four CD cord-018437-yjvwa1ot 183 20 species specie NNS cord-018437-yjvwa1ot 183 21 ) ) -RRB- cord-018437-yjvwa1ot 183 22 ; ; : cord-018437-yjvwa1ot 183 23 hepatitis hepatitis NNP cord-018437-yjvwa1ot 183 24 B B NNP cord-018437-yjvwa1ot 183 25 virus virus NN cord-018437-yjvwa1ot 183 26 ( ( -LRB- cord-018437-yjvwa1ot 183 27 HBV HBV NNP cord-018437-yjvwa1ot 183 28 ) ) -RRB- cord-018437-yjvwa1ot 183 29 , , , cord-018437-yjvwa1ot 183 30 the the DT cord-018437-yjvwa1ot 183 31 type type NN cord-018437-yjvwa1ot 183 32 species species NN cord-018437-yjvwa1ot 183 33 of of IN cord-018437-yjvwa1ot 183 34 Orthohepadnavirus Orthohepadnavirus NNP cord-018437-yjvwa1ot 183 35 , , , cord-018437-yjvwa1ot 183 36 is be VBZ cord-018437-yjvwa1ot 183 37 only only RB cord-018437-yjvwa1ot 183 38 human human JJ cord-018437-yjvwa1ot 183 39 pathogen pathogen NN cord-018437-yjvwa1ot 183 40 in in IN cord-018437-yjvwa1ot 183 41 family family NN cord-018437-yjvwa1ot 183 42 . . . cord-018437-yjvwa1ot 184 1 The the DT cord-018437-yjvwa1ot 184 2 family family NN cord-018437-yjvwa1ot 184 3 Hepadnaviridae Hepadnaviridae NNP cord-018437-yjvwa1ot 184 4 is be VBZ cord-018437-yjvwa1ot 184 5 not not RB cord-018437-yjvwa1ot 184 6 assigned assign VBN cord-018437-yjvwa1ot 184 7 to to IN cord-018437-yjvwa1ot 184 8 an an DT cord-018437-yjvwa1ot 184 9 order order NN cord-018437-yjvwa1ot 184 10 . . . cord-018437-yjvwa1ot 185 1 Eight eight CD cord-018437-yjvwa1ot 185 2 distinct distinct JJ cord-018437-yjvwa1ot 185 3 HBV HBV NNP cord-018437-yjvwa1ot 185 4 genotypes genotype NNS cord-018437-yjvwa1ot 185 5 ( ( -LRB- cord-018437-yjvwa1ot 185 6 A A NNP cord-018437-yjvwa1ot 185 7 - - HYPH cord-018437-yjvwa1ot 185 8 H H NNP cord-018437-yjvwa1ot 185 9 ) ) -RRB- cord-018437-yjvwa1ot 185 10 and and CC cord-018437-yjvwa1ot 185 11 subtypes subtype NNS cord-018437-yjvwa1ot 185 12 can can MD cord-018437-yjvwa1ot 185 13 be be VB cord-018437-yjvwa1ot 185 14 recognized recognize VBN cord-018437-yjvwa1ot 185 15 on on IN cord-018437-yjvwa1ot 185 16 the the DT cord-018437-yjvwa1ot 185 17 basis basis NN cord-018437-yjvwa1ot 185 18 of of IN cord-018437-yjvwa1ot 185 19 antigenic antigenic JJ cord-018437-yjvwa1ot 185 20 or or CC cord-018437-yjvwa1ot 185 21 sequence sequence NN cord-018437-yjvwa1ot 185 22 variation variation NN cord-018437-yjvwa1ot 185 23 . . . cord-018437-yjvwa1ot 186 1 The the DT cord-018437-yjvwa1ot 186 2 genotypes genotype NNS cord-018437-yjvwa1ot 186 3 show show VBP cord-018437-yjvwa1ot 186 4 geographic geographic JJ cord-018437-yjvwa1ot 186 5 and and CC cord-018437-yjvwa1ot 186 6 ethnic ethnic JJ cord-018437-yjvwa1ot 186 7 variability variability NN cord-018437-yjvwa1ot 186 8 ; ; : cord-018437-yjvwa1ot 186 9 the the DT cord-018437-yjvwa1ot 186 10 HBV HBV NNP cord-018437-yjvwa1ot 186 11 genotype genotype NN cord-018437-yjvwa1ot 186 12 infl infl NN cord-018437-yjvwa1ot 186 13 uences uence VBZ cord-018437-yjvwa1ot 186 14 the the DT cord-018437-yjvwa1ot 186 15 severity severity NN cord-018437-yjvwa1ot 186 16 and and CC cord-018437-yjvwa1ot 186 17 outcome outcome NN cord-018437-yjvwa1ot 186 18 of of IN cord-018437-yjvwa1ot 186 19 disease disease NN cord-018437-yjvwa1ot 186 20 ( ( -LRB- cord-018437-yjvwa1ot 186 21 Garfein Garfein NNP cord-018437-yjvwa1ot 186 22 et et NNP cord-018437-yjvwa1ot 186 23 al al NNP cord-018437-yjvwa1ot 186 24 . . . cord-018437-yjvwa1ot 187 1 2004 2004 CD cord-018437-yjvwa1ot 187 2 ; ; : cord-018437-yjvwa1ot 187 3 Lin Lin NNP cord-018437-yjvwa1ot 187 4 and and CC cord-018437-yjvwa1ot 187 5 Kao Kao NNP cord-018437-yjvwa1ot 187 6 2008 2008 CD cord-018437-yjvwa1ot 187 7 ) ) -RRB- cord-018437-yjvwa1ot 187 8 . . . cord-018437-yjvwa1ot 188 1 The the DT cord-018437-yjvwa1ot 188 2 complete complete JJ cord-018437-yjvwa1ot 188 3 , , , cord-018437-yjvwa1ot 188 4 enveloped envelop VBD cord-018437-yjvwa1ot 188 5 HBV HBV NNP cord-018437-yjvwa1ot 188 6 virion virion NN cord-018437-yjvwa1ot 188 7 ( ( -LRB- cord-018437-yjvwa1ot 188 8 Dane Dane NNP cord-018437-yjvwa1ot 188 9 particle particle NN cord-018437-yjvwa1ot 188 10 ) ) -RRB- cord-018437-yjvwa1ot 188 11 is be VBZ cord-018437-yjvwa1ot 188 12 42 42 CD cord-018437-yjvwa1ot 188 13 - - SYM cord-018437-yjvwa1ot 188 14 47 47 CD cord-018437-yjvwa1ot 188 15 nm nm NN cord-018437-yjvwa1ot 188 16 in in IN cord-018437-yjvwa1ot 188 17 diameter diameter NN cord-018437-yjvwa1ot 188 18 . . . cord-018437-yjvwa1ot 189 1 The the DT cord-018437-yjvwa1ot 189 2 icosahedral icosahedral JJ cord-018437-yjvwa1ot 189 3 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 189 4 ( ( -LRB- cord-018437-yjvwa1ot 189 5 ~28 ~28 NFP cord-018437-yjvwa1ot 189 6 nm nm NN cord-018437-yjvwa1ot 189 7 in in IN cord-018437-yjvwa1ot 189 8 diameter diameter NN cord-018437-yjvwa1ot 189 9 ) ) -RRB- cord-018437-yjvwa1ot 189 10 of of IN cord-018437-yjvwa1ot 189 11 the the DT cord-018437-yjvwa1ot 189 12 virion virion NN cord-018437-yjvwa1ot 189 13 contains contain VBZ cord-018437-yjvwa1ot 189 14 a a DT cord-018437-yjvwa1ot 189 15 single single JJ cord-018437-yjvwa1ot 189 16 molecule molecule NN cord-018437-yjvwa1ot 189 17 of of IN cord-018437-yjvwa1ot 189 18 partially partially RB cord-018437-yjvwa1ot 189 19 double double RB cord-018437-yjvwa1ot 189 20 - - HYPH cord-018437-yjvwa1ot 189 21 stranded strand VBN cord-018437-yjvwa1ot 189 22 DNA dna NN cord-018437-yjvwa1ot 189 23 with with IN cord-018437-yjvwa1ot 189 24 a a DT cord-018437-yjvwa1ot 189 25 DNA dna NN cord-018437-yjvwa1ot 189 26 - - HYPH cord-018437-yjvwa1ot 189 27 dependent dependent JJ cord-018437-yjvwa1ot 189 28 polymerase polymerase NN cord-018437-yjvwa1ot 189 29 covalently covalently RB cord-018437-yjvwa1ot 189 30 linked link VBN cord-018437-yjvwa1ot 189 31 to to IN cord-018437-yjvwa1ot 189 32 the the DT cord-018437-yjvwa1ot 189 33 5′ 5′ CD cord-018437-yjvwa1ot 189 34 end end NN cord-018437-yjvwa1ot 189 35 of of IN cord-018437-yjvwa1ot 189 36 the the DT cord-018437-yjvwa1ot 189 37 complete complete JJ cord-018437-yjvwa1ot 189 38 DNA dna NN cord-018437-yjvwa1ot 189 39 strand strand NN cord-018437-yjvwa1ot 189 40 , , , cord-018437-yjvwa1ot 189 41 hepatitis hepatitis NN cord-018437-yjvwa1ot 189 42 B b NN cord-018437-yjvwa1ot 189 43 e e NN cord-018437-yjvwa1ot 189 44 antigen antigen NN cord-018437-yjvwa1ot 189 45 ( ( -LRB- cord-018437-yjvwa1ot 189 46 HBeAg hbeag CD cord-018437-yjvwa1ot 189 47 ) ) -RRB- cord-018437-yjvwa1ot 189 48 and and CC cord-018437-yjvwa1ot 189 49 hepatitis hepatitis NNP cord-018437-yjvwa1ot 189 50 B B NNP cord-018437-yjvwa1ot 189 51 core core NN cord-018437-yjvwa1ot 189 52 antigen antigen NN cord-018437-yjvwa1ot 189 53 ( ( -LRB- cord-018437-yjvwa1ot 189 54 HBcAg hbcag CD cord-018437-yjvwa1ot 189 55 ) ) -RRB- cord-018437-yjvwa1ot 189 56 . . . cord-018437-yjvwa1ot 190 1 The the DT cord-018437-yjvwa1ot 190 2 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 190 3 is be VBZ cord-018437-yjvwa1ot 190 4 surrounded surround VBN cord-018437-yjvwa1ot 190 5 by by IN cord-018437-yjvwa1ot 190 6 an an DT cord-018437-yjvwa1ot 190 7 envelope envelope NN cord-018437-yjvwa1ot 190 8 derived derive VBN cord-018437-yjvwa1ot 190 9 from from IN cord-018437-yjvwa1ot 190 10 host host NN cord-018437-yjvwa1ot 190 11 - - HYPH cord-018437-yjvwa1ot 190 12 cell cell NN cord-018437-yjvwa1ot 190 13 membrane membrane NN cord-018437-yjvwa1ot 190 14 and and CC cord-018437-yjvwa1ot 190 15 viral viral JJ cord-018437-yjvwa1ot 190 16 envelope envelope NN cord-018437-yjvwa1ot 190 17 proteins protein NNS cord-018437-yjvwa1ot 190 18 , , , cord-018437-yjvwa1ot 190 19 including include VBG cord-018437-yjvwa1ot 190 20 hepatitis hepatitis NNP cord-018437-yjvwa1ot 190 21 B B NNP cord-018437-yjvwa1ot 190 22 surface surface NN cord-018437-yjvwa1ot 190 23 antigen antigen NN cord-018437-yjvwa1ot 190 24 . . . cord-018437-yjvwa1ot 191 1 The the DT cord-018437-yjvwa1ot 191 2 genome genome NN cord-018437-yjvwa1ot 191 3 of of IN cord-018437-yjvwa1ot 191 4 HBV HBV NNP cord-018437-yjvwa1ot 191 5 is be VBZ cord-018437-yjvwa1ot 191 6 a a DT cord-018437-yjvwa1ot 191 7 circular circular JJ cord-018437-yjvwa1ot 191 8 , , , cord-018437-yjvwa1ot 191 9 partially partially RB cord-018437-yjvwa1ot 191 10 double double RB cord-018437-yjvwa1ot 191 11 - - HYPH cord-018437-yjvwa1ot 191 12 stranded strand VBN cord-018437-yjvwa1ot 191 13 DNA dna NN cord-018437-yjvwa1ot 191 14 molecule molecule NN cord-018437-yjvwa1ot 191 15 which which WDT cord-018437-yjvwa1ot 191 16 is be VBZ cord-018437-yjvwa1ot 191 17 replicated replicate VBN cord-018437-yjvwa1ot 191 18 by by IN cord-018437-yjvwa1ot 191 19 a a DT cord-018437-yjvwa1ot 191 20 unique unique JJ cord-018437-yjvwa1ot 191 21 process process NN cord-018437-yjvwa1ot 191 22 of of IN cord-018437-yjvwa1ot 191 23 reverse reverse JJ cord-018437-yjvwa1ot 191 24 transcription transcription NN cord-018437-yjvwa1ot 191 25 of of IN cord-018437-yjvwa1ot 191 26 an an DT cord-018437-yjvwa1ot 191 27 RNA RNA NNP cord-018437-yjvwa1ot 191 28 intermediate intermediate NN cord-018437-yjvwa1ot 191 29 . . . cord-018437-yjvwa1ot 192 1 The the DT cord-018437-yjvwa1ot 192 2 minus minus JJ cord-018437-yjvwa1ot 192 3 DNA dna NN cord-018437-yjvwa1ot 192 4 strand strand NN cord-018437-yjvwa1ot 192 5 runs run VBZ cord-018437-yjvwa1ot 192 6 the the DT cord-018437-yjvwa1ot 192 7 entire entire JJ cord-018437-yjvwa1ot 192 8 length length NN cord-018437-yjvwa1ot 192 9 of of IN cord-018437-yjvwa1ot 192 10 the the DT cord-018437-yjvwa1ot 192 11 HBV HBV NNP cord-018437-yjvwa1ot 192 12 genome genome NN cord-018437-yjvwa1ot 192 13 ; ; : cord-018437-yjvwa1ot 192 14 the the DT cord-018437-yjvwa1ot 192 15 plus plus JJ cord-018437-yjvwa1ot 192 16 strand strand NN cord-018437-yjvwa1ot 192 17 covers cover VBZ cord-018437-yjvwa1ot 192 18 only only RB cord-018437-yjvwa1ot 192 19 about about RB cord-018437-yjvwa1ot 192 20 two two CD cord-018437-yjvwa1ot 192 21 - - HYPH cord-018437-yjvwa1ot 192 22 thirds third NNS cord-018437-yjvwa1ot 192 23 of of IN cord-018437-yjvwa1ot 192 24 the the DT cord-018437-yjvwa1ot 192 25 genome genome NN cord-018437-yjvwa1ot 192 26 . . . cord-018437-yjvwa1ot 193 1 The the DT cord-018437-yjvwa1ot 193 2 genome genome NN cord-018437-yjvwa1ot 193 3 is be VBZ cord-018437-yjvwa1ot 193 4 replicated replicate VBN cord-018437-yjvwa1ot 193 5 by by IN cord-018437-yjvwa1ot 193 6 synthesis synthesis NN cord-018437-yjvwa1ot 193 7 of of IN cord-018437-yjvwa1ot 193 8 a a DT cord-018437-yjvwa1ot 193 9 fulllength fulllength NN cord-018437-yjvwa1ot 193 10 ssRNA ssrna NN cord-018437-yjvwa1ot 193 11 transcript transcript NN cord-018437-yjvwa1ot 193 12 ( ( -LRB- cord-018437-yjvwa1ot 193 13 pre pre JJ cord-018437-yjvwa1ot 193 14 - - JJ cord-018437-yjvwa1ot 193 15 genomic genomic JJ cord-018437-yjvwa1ot 193 16 RNA RNA NNP cord-018437-yjvwa1ot 193 17 ) ) -RRB- cord-018437-yjvwa1ot 193 18 , , , cord-018437-yjvwa1ot 193 19 followed follow VBN cord-018437-yjvwa1ot 193 20 by by IN cord-018437-yjvwa1ot 193 21 dsDNA dsdna JJ cord-018437-yjvwa1ot 193 22 synthesis synthesis NN cord-018437-yjvwa1ot 193 23 by by IN cord-018437-yjvwa1ot 193 24 reverse reverse JJ cord-018437-yjvwa1ot 193 25 transcription transcription NN cord-018437-yjvwa1ot 193 26 of of IN cord-018437-yjvwa1ot 193 27 the the DT cord-018437-yjvwa1ot 193 28 ssRNA ssrna NN cord-018437-yjvwa1ot 193 29 by by IN cord-018437-yjvwa1ot 193 30 viral viral RB cord-018437-yjvwa1ot 193 31 - - HYPH cord-018437-yjvwa1ot 193 32 encoded encode VBN cord-018437-yjvwa1ot 193 33 reverse reverse JJ cord-018437-yjvwa1ot 193 34 transcriptase transcriptase NN cord-018437-yjvwa1ot 193 35 / / SYM cord-018437-yjvwa1ot 193 36 DNA dna NN cord-018437-yjvwa1ot 193 37 polymerase polymerase NN cord-018437-yjvwa1ot 193 38 . . . cord-018437-yjvwa1ot 194 1 All all DT cord-018437-yjvwa1ot 194 2 viral viral JJ cord-018437-yjvwa1ot 194 3 proteins protein NNS cord-018437-yjvwa1ot 194 4 are be VBP cord-018437-yjvwa1ot 194 5 also also RB cord-018437-yjvwa1ot 194 6 transcribed transcribe VBN cord-018437-yjvwa1ot 194 7 from from IN cord-018437-yjvwa1ot 194 8 the the DT cord-018437-yjvwa1ot 194 9 minus minus JJ cord-018437-yjvwa1ot 194 10 DNA dna NN cord-018437-yjvwa1ot 194 11 strand strand NN cord-018437-yjvwa1ot 194 12 . . . cord-018437-yjvwa1ot 195 1 There there EX cord-018437-yjvwa1ot 195 2 are be VBP cord-018437-yjvwa1ot 195 3 four four CD cord-018437-yjvwa1ot 195 4 overlapping overlap VBG cord-018437-yjvwa1ot 195 5 open open JJ cord-018437-yjvwa1ot 195 6 reading reading NN cord-018437-yjvwa1ot 195 7 frames frame NNS cord-018437-yjvwa1ot 195 8 , , , cord-018437-yjvwa1ot 195 9 all all DT cord-018437-yjvwa1ot 195 10 read read VBN cord-018437-yjvwa1ot 195 11 in in IN cord-018437-yjvwa1ot 195 12 the the DT cord-018437-yjvwa1ot 195 13 same same JJ cord-018437-yjvwa1ot 195 14 direction direction NN cord-018437-yjvwa1ot 195 15 ( ( -LRB- cord-018437-yjvwa1ot 195 16 Liang Liang NNP cord-018437-yjvwa1ot 195 17 2009 2009 CD cord-018437-yjvwa1ot 195 18 ) ) -RRB- cord-018437-yjvwa1ot 195 19 . . . cord-018437-yjvwa1ot 196 1 Herpesviridae herpesviridae NN cord-018437-yjvwa1ot 196 2 : : : cord-018437-yjvwa1ot 197 1 The the DT cord-018437-yjvwa1ot 197 2 herpesvirus herpesvirus NN cord-018437-yjvwa1ot 197 3 species species NN cord-018437-yjvwa1ot 197 4 associated associate VBN cord-018437-yjvwa1ot 197 5 with with IN cord-018437-yjvwa1ot 197 6 human human JJ cord-018437-yjvwa1ot 197 7 infections infection NNS cord-018437-yjvwa1ot 197 8 ( ( -LRB- cord-018437-yjvwa1ot 197 9 HSV-1 hsv-1 NN cord-018437-yjvwa1ot 197 10 , , , cord-018437-yjvwa1ot 197 11 HSV-2 HSV-2 NNP cord-018437-yjvwa1ot 197 12 , , , cord-018437-yjvwa1ot 197 13 CMV CMV NNP cord-018437-yjvwa1ot 197 14 , , , cord-018437-yjvwa1ot 197 15 EBV EBV NNP cord-018437-yjvwa1ot 197 16 , , , cord-018437-yjvwa1ot 197 17 VZV VZV NNP cord-018437-yjvwa1ot 197 18 , , , cord-018437-yjvwa1ot 197 19 HHV-6 HHV-6 NNP cord-018437-yjvwa1ot 197 20 , , , cord-018437-yjvwa1ot 197 21 HHV-7 HHV-7 NNP cord-018437-yjvwa1ot 197 22 , , , cord-018437-yjvwa1ot 197 23 and and CC cord-018437-yjvwa1ot 197 24 HHV-8 HHV-8 NNP cord-018437-yjvwa1ot 197 25 ) ) -RRB- cord-018437-yjvwa1ot 197 26 belong belong VBP cord-018437-yjvwa1ot 197 27 to to IN cord-018437-yjvwa1ot 197 28 the the DT cord-018437-yjvwa1ot 197 29 family family NN cord-018437-yjvwa1ot 197 30 Herpesviridae Herpesviridae NNP cord-018437-yjvwa1ot 197 31 within within IN cord-018437-yjvwa1ot 197 32 the the DT cord-018437-yjvwa1ot 197 33 order order NN cord-018437-yjvwa1ot 197 34 Herpesvirales Herpesvirales NNP cord-018437-yjvwa1ot 197 35 . . . cord-018437-yjvwa1ot 198 1 There there EX cord-018437-yjvwa1ot 198 2 are be VBP cord-018437-yjvwa1ot 198 3 four four CD cord-018437-yjvwa1ot 198 4 subfamilies subfamily NNS cord-018437-yjvwa1ot 198 5 of of IN cord-018437-yjvwa1ot 198 6 the the DT cord-018437-yjvwa1ot 198 7 Herpesviridae Herpesviridae NNP cord-018437-yjvwa1ot 198 8 : : : cord-018437-yjvwa1ot 198 9 Alphaherpesvirinae Alphaherpesvirinae NNP cord-018437-yjvwa1ot 198 10 ( ( -LRB- cord-018437-yjvwa1ot 198 11 5 5 CD cord-018437-yjvwa1ot 198 12 genera genus NNS cord-018437-yjvwa1ot 198 13 ) ) -RRB- cord-018437-yjvwa1ot 198 14 , , , cord-018437-yjvwa1ot 198 15 Betaherpesvirinae Betaherpesvirinae NNP cord-018437-yjvwa1ot 198 16 ( ( -LRB- cord-018437-yjvwa1ot 198 17 4 4 CD cord-018437-yjvwa1ot 198 18 genera genus NNS cord-018437-yjvwa1ot 198 19 ) ) -RRB- cord-018437-yjvwa1ot 198 20 , , , cord-018437-yjvwa1ot 198 21 Gammaherpesvirinae Gammaherpesvirinae NNP cord-018437-yjvwa1ot 198 22 ( ( -LRB- cord-018437-yjvwa1ot 198 23 4 4 CD cord-018437-yjvwa1ot 198 24 genera genus NNS cord-018437-yjvwa1ot 198 25 ) ) -RRB- cord-018437-yjvwa1ot 198 26 , , , cord-018437-yjvwa1ot 198 27 and and CC cord-018437-yjvwa1ot 198 28 a a DT cord-018437-yjvwa1ot 198 29 single single JJ cord-018437-yjvwa1ot 198 30 genus genus NN cord-018437-yjvwa1ot 198 31 in in IN cord-018437-yjvwa1ot 198 32 an an DT cord-018437-yjvwa1ot 198 33 unassigned unassigned JJ cord-018437-yjvwa1ot 198 34 subfamily subfamily NN cord-018437-yjvwa1ot 198 35 . . . cord-018437-yjvwa1ot 199 1 Specifi Specifi NNP cord-018437-yjvwa1ot 199 2 c c NN cord-018437-yjvwa1ot 199 3 human human JJ cord-018437-yjvwa1ot 199 4 herpesviruses herpesviruse NNS cord-018437-yjvwa1ot 199 5 are be VBP cord-018437-yjvwa1ot 199 6 discussed discuss VBN cord-018437-yjvwa1ot 199 7 in in IN cord-018437-yjvwa1ot 199 8 the the DT cord-018437-yjvwa1ot 199 9 sections section NNS cord-018437-yjvwa1ot 199 10 below below RB cord-018437-yjvwa1ot 199 11 . . . cord-018437-yjvwa1ot 200 1 The the DT cord-018437-yjvwa1ot 200 2 herpesviruses herpesviruse NNS cord-018437-yjvwa1ot 200 3 are be VBP cord-018437-yjvwa1ot 200 4 double double RB cord-018437-yjvwa1ot 200 5 - - HYPH cord-018437-yjvwa1ot 200 6 stranded strand VBN cord-018437-yjvwa1ot 200 7 DNA dna NN cord-018437-yjvwa1ot 200 8 viruses virus NNS cord-018437-yjvwa1ot 200 9 . . . cord-018437-yjvwa1ot 201 1 The the DT cord-018437-yjvwa1ot 201 2 icosahedral icosahedral JJ cord-018437-yjvwa1ot 201 3 capsid capsid NN cord-018437-yjvwa1ot 201 4 ( ( -LRB- cord-018437-yjvwa1ot 201 5 ~100 ~100 NFP cord-018437-yjvwa1ot 201 6 nm nm NN cord-018437-yjvwa1ot 201 7 diameter diameter NN cord-018437-yjvwa1ot 201 8 ) ) -RRB- cord-018437-yjvwa1ot 201 9 is be VBZ cord-018437-yjvwa1ot 201 10 surrounded surround VBN cord-018437-yjvwa1ot 201 11 by by IN cord-018437-yjvwa1ot 201 12 an an DT cord-018437-yjvwa1ot 201 13 envelope envelope NN cord-018437-yjvwa1ot 201 14 studded stud VBN cord-018437-yjvwa1ot 201 15 by by IN cord-018437-yjvwa1ot 201 16 a a DT cord-018437-yjvwa1ot 201 17 variety variety NN cord-018437-yjvwa1ot 201 18 of of IN cord-018437-yjvwa1ot 201 19 short short JJ cord-018437-yjvwa1ot 201 20 glycoproteins glycoprotein NNS cord-018437-yjvwa1ot 201 21 . . . cord-018437-yjvwa1ot 202 1 The the DT cord-018437-yjvwa1ot 202 2 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 202 3 is be VBZ cord-018437-yjvwa1ot 202 4 a a DT cord-018437-yjvwa1ot 202 5 dense dense JJ cord-018437-yjvwa1ot 202 6 toroid toroid NN cord-018437-yjvwa1ot 202 7 complex complex NN cord-018437-yjvwa1ot 202 8 with with IN cord-018437-yjvwa1ot 202 9 an an DT cord-018437-yjvwa1ot 202 10 outer outer JJ cord-018437-yjvwa1ot 202 11 diameter diameter NN cord-018437-yjvwa1ot 202 12 ~70 ~70 NFP cord-018437-yjvwa1ot 202 13 nm nm NN cord-018437-yjvwa1ot 202 14 and and CC cord-018437-yjvwa1ot 202 15 inner inner JJ cord-018437-yjvwa1ot 202 16 diameter diameter NN cord-018437-yjvwa1ot 202 17 ~18 ~18 XX cord-018437-yjvwa1ot 202 18 nm nm NN cord-018437-yjvwa1ot 202 19 . . . cord-018437-yjvwa1ot 203 1 An an DT cord-018437-yjvwa1ot 203 2 irregular irregular JJ cord-018437-yjvwa1ot 203 3 " " `` cord-018437-yjvwa1ot 203 4 tegument tegument NN cord-018437-yjvwa1ot 203 5 " " '' cord-018437-yjvwa1ot 203 6 fi fi NNP cord-018437-yjvwa1ot 203 7 lls ll VBZ cord-018437-yjvwa1ot 203 8 the the DT cord-018437-yjvwa1ot 203 9 space space NN cord-018437-yjvwa1ot 203 10 between between IN cord-018437-yjvwa1ot 203 11 the the DT cord-018437-yjvwa1ot 203 12 envelope envelope NN cord-018437-yjvwa1ot 203 13 and and CC cord-018437-yjvwa1ot 203 14 capsid capsid NN cord-018437-yjvwa1ot 203 15 . . . cord-018437-yjvwa1ot 204 1 Depending depend VBG cord-018437-yjvwa1ot 204 2 of of IN cord-018437-yjvwa1ot 204 3 the the DT cord-018437-yjvwa1ot 204 4 thickness thickness NN cord-018437-yjvwa1ot 204 5 of of IN cord-018437-yjvwa1ot 204 6 the the DT cord-018437-yjvwa1ot 204 7 tegument tegument NN cord-018437-yjvwa1ot 204 8 layer layer NN cord-018437-yjvwa1ot 204 9 , , , cord-018437-yjvwa1ot 204 10 complete complete JJ cord-018437-yjvwa1ot 204 11 virions virion NNS cord-018437-yjvwa1ot 204 12 range range VBP cord-018437-yjvwa1ot 204 13 in in IN cord-018437-yjvwa1ot 204 14 size size NN cord-018437-yjvwa1ot 204 15 from from IN cord-018437-yjvwa1ot 204 16 ~125 ~125 NN cord-018437-yjvwa1ot 204 17 to to IN cord-018437-yjvwa1ot 204 18 > > XX cord-018437-yjvwa1ot 204 19 250 250 CD cord-018437-yjvwa1ot 204 20 nm nm NN cord-018437-yjvwa1ot 204 21 . . . cord-018437-yjvwa1ot 205 1 The the DT cord-018437-yjvwa1ot 205 2 size size NN cord-018437-yjvwa1ot 205 3 and and CC cord-018437-yjvwa1ot 205 4 organization organization NN cord-018437-yjvwa1ot 205 5 of of IN cord-018437-yjvwa1ot 205 6 the the DT cord-018437-yjvwa1ot 205 7 dsDNA dsDNA NNP cord-018437-yjvwa1ot 205 8 genome genome NN cord-018437-yjvwa1ot 205 9 varies vary VBZ cord-018437-yjvwa1ot 205 10 among among IN cord-018437-yjvwa1ot 205 11 the the DT cord-018437-yjvwa1ot 205 12 species specie NNS cord-018437-yjvwa1ot 205 13 causing cause VBG cord-018437-yjvwa1ot 205 14 human human JJ cord-018437-yjvwa1ot 205 15 disease disease NN cord-018437-yjvwa1ot 205 16 ( ( -LRB- cord-018437-yjvwa1ot 205 17 McGeoch McGeoch NNP cord-018437-yjvwa1ot 205 18 et et NNP cord-018437-yjvwa1ot 205 19 al al NNP cord-018437-yjvwa1ot 205 20 . . . cord-018437-yjvwa1ot 205 21 2006 2006 CD cord-018437-yjvwa1ot 205 22 ) ) -RRB- cord-018437-yjvwa1ot 205 23 . . . cord-018437-yjvwa1ot 206 1 The the DT cord-018437-yjvwa1ot 206 2 genomes genome NNS cord-018437-yjvwa1ot 206 3 of of IN cord-018437-yjvwa1ot 206 4 human human JJ cord-018437-yjvwa1ot 206 5 herpesviruses herpesviruse NNS cord-018437-yjvwa1ot 206 6 include include VBP cord-018437-yjvwa1ot 206 7 unique unique JJ cord-018437-yjvwa1ot 206 8 sequences sequence NNS cord-018437-yjvwa1ot 206 9 and and CC cord-018437-yjvwa1ot 206 10 repeated repeat VBN cord-018437-yjvwa1ot 206 11 sequences sequence NNS cord-018437-yjvwa1ot 206 12 . . . cord-018437-yjvwa1ot 207 1 Though though IN cord-018437-yjvwa1ot 207 2 the the DT cord-018437-yjvwa1ot 207 3 genomes genome NNS cord-018437-yjvwa1ot 207 4 are be VBP cord-018437-yjvwa1ot 207 5 linear linear JJ cord-018437-yjvwa1ot 207 6 in in IN cord-018437-yjvwa1ot 207 7 virions virion NNS cord-018437-yjvwa1ot 207 8 , , , cord-018437-yjvwa1ot 207 9 they -PRON- PRP cord-018437-yjvwa1ot 207 10 circularize circularize VBP cord-018437-yjvwa1ot 207 11 in in IN cord-018437-yjvwa1ot 207 12 the the DT cord-018437-yjvwa1ot 207 13 nucleus nucleus NN cord-018437-yjvwa1ot 207 14 of of IN cord-018437-yjvwa1ot 207 15 infected infected JJ cord-018437-yjvwa1ot 207 16 cells cell NNS cord-018437-yjvwa1ot 207 17 , , , cord-018437-yjvwa1ot 207 18 which which WDT cord-018437-yjvwa1ot 207 19 is be VBZ cord-018437-yjvwa1ot 207 20 mediated mediate VBN cord-018437-yjvwa1ot 207 21 through through IN cord-018437-yjvwa1ot 207 22 repeat repeat NN cord-018437-yjvwa1ot 207 23 sequences sequence NNS cord-018437-yjvwa1ot 207 24 at at IN cord-018437-yjvwa1ot 207 25 both both DT cord-018437-yjvwa1ot 207 26 ends end NNS cord-018437-yjvwa1ot 207 27 of of IN cord-018437-yjvwa1ot 207 28 the the DT cord-018437-yjvwa1ot 207 29 dsDNA dsDNA NNP cord-018437-yjvwa1ot 207 30 genome genome NN cord-018437-yjvwa1ot 207 31 . . . cord-018437-yjvwa1ot 208 1 For for IN cord-018437-yjvwa1ot 208 2 HHV6 HHV6 NNP cord-018437-yjvwa1ot 208 3 and and CC cord-018437-yjvwa1ot 208 4 HHV7 HHV7 NNP cord-018437-yjvwa1ot 208 5 ( ( -LRB- cord-018437-yjvwa1ot 208 6 class class NN cord-018437-yjvwa1ot 208 7 A A NNP cord-018437-yjvwa1ot 208 8 genome genome NN cord-018437-yjvwa1ot 208 9 ) ) -RRB- cord-018437-yjvwa1ot 208 10 , , , cord-018437-yjvwa1ot 208 11 a a DT cord-018437-yjvwa1ot 208 12 large large JJ cord-018437-yjvwa1ot 208 13 unique unique JJ cord-018437-yjvwa1ot 208 14 sequence sequence NN cord-018437-yjvwa1ot 208 15 region region NN cord-018437-yjvwa1ot 208 16 is be VBZ cord-018437-yjvwa1ot 208 17 fl fl NNP cord-018437-yjvwa1ot 208 18 anked anke VBN cord-018437-yjvwa1ot 208 19 by by IN cord-018437-yjvwa1ot 208 20 a a DT cord-018437-yjvwa1ot 208 21 region region NN cord-018437-yjvwa1ot 208 22 that that WDT cord-018437-yjvwa1ot 208 23 is be VBZ cord-018437-yjvwa1ot 208 24 repeated repeat VBN cord-018437-yjvwa1ot 208 25 at at IN cord-018437-yjvwa1ot 208 26 both both DT cord-018437-yjvwa1ot 208 27 ends end NNS cord-018437-yjvwa1ot 208 28 of of IN cord-018437-yjvwa1ot 208 29 the the DT cord-018437-yjvwa1ot 208 30 linear linear JJ cord-018437-yjvwa1ot 208 31 strand strand NN cord-018437-yjvwa1ot 208 32 of of IN cord-018437-yjvwa1ot 208 33 dsDNA dsdna RB cord-018437-yjvwa1ot 208 34 . . . cord-018437-yjvwa1ot 209 1 The the DT cord-018437-yjvwa1ot 209 2 genome genome NN cord-018437-yjvwa1ot 209 3 of of IN cord-018437-yjvwa1ot 209 4 EBV EBV NNP cord-018437-yjvwa1ot 209 5 and and CC cord-018437-yjvwa1ot 209 6 the the DT cord-018437-yjvwa1ot 209 7 Kaposi Kaposi NNP cord-018437-yjvwa1ot 209 8 's 's POS cord-018437-yjvwa1ot 209 9 sarcoma sarcoma NN cord-018437-yjvwa1ot 209 10 - - HYPH cord-018437-yjvwa1ot 209 11 associated associate VBN cord-018437-yjvwa1ot 209 12 herpesvirus herpesvirus NN cord-018437-yjvwa1ot 209 13 ( ( -LRB- cord-018437-yjvwa1ot 209 14 class class NN cord-018437-yjvwa1ot 209 15 C c NN cord-018437-yjvwa1ot 209 16 genome genome NN cord-018437-yjvwa1ot 209 17 ) ) -RRB- cord-018437-yjvwa1ot 209 18 have have VBP cord-018437-yjvwa1ot 209 19 smaller small JJR cord-018437-yjvwa1ot 209 20 left leave VBN cord-018437-yjvwa1ot 209 21 and and CC cord-018437-yjvwa1ot 209 22 right right JJ cord-018437-yjvwa1ot 209 23 terminal terminal NN cord-018437-yjvwa1ot 209 24 repeat repeat NN cord-018437-yjvwa1ot 209 25 sequences sequence NNS cord-018437-yjvwa1ot 209 26 , , , cord-018437-yjvwa1ot 209 27 while while IN cord-018437-yjvwa1ot 209 28 repeat repeat NN cord-018437-yjvwa1ot 209 29 sequences sequence NNS cord-018437-yjvwa1ot 209 30 R1 R1 NNP cord-018437-yjvwa1ot 209 31 to to IN cord-018437-yjvwa1ot 209 32 R4 R4 NNP cord-018437-yjvwa1ot 209 33 divide divide VB cord-018437-yjvwa1ot 209 34 the the DT cord-018437-yjvwa1ot 209 35 unique unique JJ cord-018437-yjvwa1ot 209 36 sequence sequence NN cord-018437-yjvwa1ot 209 37 nucleic nucleic VBZ cord-018437-yjvwa1ot 209 38 acid acid NN cord-018437-yjvwa1ot 209 39 into into IN cord-018437-yjvwa1ot 209 40 four four CD cord-018437-yjvwa1ot 209 41 discrete discrete JJ cord-018437-yjvwa1ot 209 42 regions region NNS cord-018437-yjvwa1ot 209 43 . . . cord-018437-yjvwa1ot 210 1 For for IN cord-018437-yjvwa1ot 210 2 VZV VZV NNP cord-018437-yjvwa1ot 210 3 ( ( -LRB- cord-018437-yjvwa1ot 210 4 class class NN cord-018437-yjvwa1ot 210 5 D d NN cord-018437-yjvwa1ot 210 6 genome genome NN cord-018437-yjvwa1ot 210 7 ) ) -RRB- cord-018437-yjvwa1ot 210 8 , , , cord-018437-yjvwa1ot 210 9 a a DT cord-018437-yjvwa1ot 210 10 large large JJ cord-018437-yjvwa1ot 210 11 terminal terminal JJ cord-018437-yjvwa1ot 210 12 sequence sequence NN cord-018437-yjvwa1ot 210 13 is be VBZ cord-018437-yjvwa1ot 210 14 inverted invert VBN cord-018437-yjvwa1ot 210 15 and and CC cord-018437-yjvwa1ot 210 16 inserted insert VBN cord-018437-yjvwa1ot 210 17 into into IN cord-018437-yjvwa1ot 210 18 the the DT cord-018437-yjvwa1ot 210 19 genome genome NN cord-018437-yjvwa1ot 210 20 , , , cord-018437-yjvwa1ot 210 21 resulting result VBG cord-018437-yjvwa1ot 210 22 in in IN cord-018437-yjvwa1ot 210 23 a a DT cord-018437-yjvwa1ot 210 24 large large JJ cord-018437-yjvwa1ot 210 25 unique unique JJ cord-018437-yjvwa1ot 210 26 sequence sequence NN cord-018437-yjvwa1ot 210 27 region region NN cord-018437-yjvwa1ot 210 28 ( ( -LRB- cord-018437-yjvwa1ot 210 29 UL UL NNP cord-018437-yjvwa1ot 210 30 ) ) -RRB- cord-018437-yjvwa1ot 210 31 and and CC cord-018437-yjvwa1ot 210 32 a a DT cord-018437-yjvwa1ot 210 33 small small JJ cord-018437-yjvwa1ot 210 34 unique unique JJ cord-018437-yjvwa1ot 210 35 sequence sequence NN cord-018437-yjvwa1ot 210 36 region region NN cord-018437-yjvwa1ot 210 37 ( ( -LRB- cord-018437-yjvwa1ot 210 38 US US NNP cord-018437-yjvwa1ot 210 39 ) ) -RRB- cord-018437-yjvwa1ot 210 40 . . . cord-018437-yjvwa1ot 211 1 HSV-1 hsv-1 NN cord-018437-yjvwa1ot 211 2 , , , cord-018437-yjvwa1ot 211 3 HSV-2 HSV-2 NNP cord-018437-yjvwa1ot 211 4 , , , cord-018437-yjvwa1ot 211 5 and and CC cord-018437-yjvwa1ot 211 6 CMV CMV NNP cord-018437-yjvwa1ot 211 7 ( ( -LRB- cord-018437-yjvwa1ot 211 8 class class NN cord-018437-yjvwa1ot 211 9 E e NN cord-018437-yjvwa1ot 211 10 genomes genome NNS cord-018437-yjvwa1ot 211 11 ) ) -RRB- cord-018437-yjvwa1ot 211 12 are be VBP cord-018437-yjvwa1ot 211 13 the the DT cord-018437-yjvwa1ot 211 14 most most RBS cord-018437-yjvwa1ot 211 15 complex complex JJ cord-018437-yjvwa1ot 211 16 . . . cord-018437-yjvwa1ot 212 1 There there EX cord-018437-yjvwa1ot 212 2 are be VBP cord-018437-yjvwa1ot 212 3 repeat repeat NN cord-018437-yjvwa1ot 212 4 sequence sequence NN cord-018437-yjvwa1ot 212 5 regions region NNS cord-018437-yjvwa1ot 212 6 at at IN cord-018437-yjvwa1ot 212 7 both both DT cord-018437-yjvwa1ot 212 8 ends end NNS cord-018437-yjvwa1ot 212 9 of of IN cord-018437-yjvwa1ot 212 10 the the DT cord-018437-yjvwa1ot 212 11 linear linear JJ cord-018437-yjvwa1ot 212 12 dsDNA dsdna RB cord-018437-yjvwa1ot 212 13 molecule molecule NN cord-018437-yjvwa1ot 212 14 . . . cord-018437-yjvwa1ot 213 1 The the DT cord-018437-yjvwa1ot 213 2 unique unique JJ cord-018437-yjvwa1ot 213 3 sequence sequence NN cord-018437-yjvwa1ot 213 4 dsDNA dsdna RB cord-018437-yjvwa1ot 213 5 is be VBZ cord-018437-yjvwa1ot 213 6 divided divide VBN cord-018437-yjvwa1ot 213 7 into into IN cord-018437-yjvwa1ot 213 8 UL UL NNP cord-018437-yjvwa1ot 213 9 and and CC cord-018437-yjvwa1ot 213 10 US US NNP cord-018437-yjvwa1ot 213 11 regions region NNS cord-018437-yjvwa1ot 213 12 by by IN cord-018437-yjvwa1ot 213 13 a a DT cord-018437-yjvwa1ot 213 14 sequence sequence NN cord-018437-yjvwa1ot 213 15 composed compose VBN cord-018437-yjvwa1ot 213 16 of of IN cord-018437-yjvwa1ot 213 17 juxtaposed juxtaposed JJ cord-018437-yjvwa1ot 213 18 copies copy NNS cord-018437-yjvwa1ot 213 19 of of IN cord-018437-yjvwa1ot 213 20 the the DT cord-018437-yjvwa1ot 213 21 terminal terminal JJ cord-018437-yjvwa1ot 213 22 repeat repeat NN cord-018437-yjvwa1ot 213 23 sequences sequence NNS cord-018437-yjvwa1ot 213 24 inserted insert VBN cord-018437-yjvwa1ot 213 25 in in IN cord-018437-yjvwa1ot 213 26 an an DT cord-018437-yjvwa1ot 213 27 inverted inverted JJ cord-018437-yjvwa1ot 213 28 orientation orientation NN cord-018437-yjvwa1ot 213 29 . . . cord-018437-yjvwa1ot 214 1 Typical typical JJ cord-018437-yjvwa1ot 214 2 of of IN cord-018437-yjvwa1ot 214 3 dsDNA dsdna JJ cord-018437-yjvwa1ot 214 4 viruses virus NNS cord-018437-yjvwa1ot 214 5 , , , cord-018437-yjvwa1ot 214 6 a a DT cord-018437-yjvwa1ot 214 7 large large JJ cord-018437-yjvwa1ot 214 8 number number NN cord-018437-yjvwa1ot 214 9 of of IN cord-018437-yjvwa1ot 214 10 proteins protein NNS cord-018437-yjvwa1ot 214 11 are be VBP cord-018437-yjvwa1ot 214 12 produced produce VBN cord-018437-yjvwa1ot 214 13 by by IN cord-018437-yjvwa1ot 214 14 various various JJ cord-018437-yjvwa1ot 214 15 herpesviruses herpesviruse NNS cord-018437-yjvwa1ot 214 16 . . . cord-018437-yjvwa1ot 215 1 The the DT cord-018437-yjvwa1ot 215 2 organization organization NN cord-018437-yjvwa1ot 215 3 of of IN cord-018437-yjvwa1ot 215 4 the the DT cord-018437-yjvwa1ot 215 5 coding code VBG cord-018437-yjvwa1ot 215 6 regions region NNS cord-018437-yjvwa1ot 215 7 is be VBZ cord-018437-yjvwa1ot 215 8 complex complex JJ cord-018437-yjvwa1ot 215 9 , , , cord-018437-yjvwa1ot 215 10 with with IN cord-018437-yjvwa1ot 215 11 3′ 3′ CD cord-018437-yjvwa1ot 215 12 and and CC cord-018437-yjvwa1ot 215 13 5′ 5′ CD cord-018437-yjvwa1ot 215 14 reading read VBG cord-018437-yjvwa1ot 215 15 frames frame NNS cord-018437-yjvwa1ot 215 16 , , , cord-018437-yjvwa1ot 215 17 gene gene NN cord-018437-yjvwa1ot 215 18 overlap overlap NN cord-018437-yjvwa1ot 215 19 , , , cord-018437-yjvwa1ot 215 20 spliced splice VBN cord-018437-yjvwa1ot 215 21 genes gene NNS cord-018437-yjvwa1ot 215 22 , , , cord-018437-yjvwa1ot 215 23 and and CC cord-018437-yjvwa1ot 215 24 intron intron NN cord-018437-yjvwa1ot 215 25 regions region NNS cord-018437-yjvwa1ot 215 26 . . . cord-018437-yjvwa1ot 216 1 Forty forty CD cord-018437-yjvwa1ot 216 2 genes gene NNS cord-018437-yjvwa1ot 216 3 are be VBP cord-018437-yjvwa1ot 216 4 conserved conserve VBN cord-018437-yjvwa1ot 216 5 among among IN cord-018437-yjvwa1ot 216 6 the the DT cord-018437-yjvwa1ot 216 7 α- α- NN cord-018437-yjvwa1ot 216 8 , , , cord-018437-yjvwa1ot 216 9 β- β- XX cord-018437-yjvwa1ot 216 10 , , , cord-018437-yjvwa1ot 216 11 and and CC cord-018437-yjvwa1ot 216 12 γ γ NN cord-018437-yjvwa1ot 216 13 - - HYPH cord-018437-yjvwa1ot 216 14 herpesviruses herpesviruses NNP cord-018437-yjvwa1ot 216 15 . . . cord-018437-yjvwa1ot 217 1 These these DT cord-018437-yjvwa1ot 217 2 core core NN cord-018437-yjvwa1ot 217 3 genes gene NNS cord-018437-yjvwa1ot 217 4 are be VBP cord-018437-yjvwa1ot 217 5 divided divide VBN cord-018437-yjvwa1ot 217 6 among among IN cord-018437-yjvwa1ot 217 7 seven seven CD cord-018437-yjvwa1ot 217 8 gene gene NN cord-018437-yjvwa1ot 217 9 blocks block NNS cord-018437-yjvwa1ot 218 1 ( ( -LRB- cord-018437-yjvwa1ot 218 2 Albà Albà NNP cord-018437-yjvwa1ot 218 3 et et NNP cord-018437-yjvwa1ot 218 4 al al NNP cord-018437-yjvwa1ot 218 5 . . NNP cord-018437-yjvwa1ot 218 6 2001 2001 CD cord-018437-yjvwa1ot 218 7 ) ) -RRB- cord-018437-yjvwa1ot 218 8 ; ; : cord-018437-yjvwa1ot 218 9 within within IN cord-018437-yjvwa1ot 218 10 each each DT cord-018437-yjvwa1ot 218 11 block block NN cord-018437-yjvwa1ot 218 12 the the DT cord-018437-yjvwa1ot 218 13 order order NN cord-018437-yjvwa1ot 218 14 and and CC cord-018437-yjvwa1ot 218 15 polarity polarity NN cord-018437-yjvwa1ot 218 16 of of IN cord-018437-yjvwa1ot 218 17 genes gene NNS cord-018437-yjvwa1ot 218 18 are be VBP cord-018437-yjvwa1ot 218 19 conserved conserve VBN cord-018437-yjvwa1ot 218 20 , , , cord-018437-yjvwa1ot 218 21 including include VBG cord-018437-yjvwa1ot 218 22 genes gene NNS cord-018437-yjvwa1ot 218 23 for for IN cord-018437-yjvwa1ot 218 24 gene gene NN cord-018437-yjvwa1ot 218 25 regulation regulation NN cord-018437-yjvwa1ot 218 26 , , , cord-018437-yjvwa1ot 218 27 nucleotide nucleotide JJ cord-018437-yjvwa1ot 218 28 metabolism metabolism NN cord-018437-yjvwa1ot 218 29 , , , cord-018437-yjvwa1ot 218 30 DNA dna NN cord-018437-yjvwa1ot 218 31 replication replication NN cord-018437-yjvwa1ot 218 32 , , , cord-018437-yjvwa1ot 218 33 virion virion NN cord-018437-yjvwa1ot 218 34 maturation maturation NN cord-018437-yjvwa1ot 218 35 , , , cord-018437-yjvwa1ot 218 36 envelope envelope NN cord-018437-yjvwa1ot 218 37 glycoprotein glycoprotein NN cord-018437-yjvwa1ot 218 38 synthesis synthesis NN cord-018437-yjvwa1ot 218 39 , , , cord-018437-yjvwa1ot 218 40 and and CC cord-018437-yjvwa1ot 218 41 capsid capsid NN cord-018437-yjvwa1ot 218 42 , , , cord-018437-yjvwa1ot 218 43 fusion fusion NN cord-018437-yjvwa1ot 218 44 and and CC cord-018437-yjvwa1ot 218 45 tegument tegument NN cord-018437-yjvwa1ot 218 46 protein protein NN cord-018437-yjvwa1ot 218 47 synthesis synthesis NN cord-018437-yjvwa1ot 218 48 . . . cord-018437-yjvwa1ot 219 1 Diseases disease NNS cord-018437-yjvwa1ot 219 2 caused cause VBN cord-018437-yjvwa1ot 219 3 by by IN cord-018437-yjvwa1ot 219 4 human human JJ cord-018437-yjvwa1ot 219 5 herpesviruses herpesviruse NNS cord-018437-yjvwa1ot 219 6 range range NN cord-018437-yjvwa1ot 219 7 from from IN cord-018437-yjvwa1ot 219 8 systemic systemic JJ cord-018437-yjvwa1ot 219 9 to to IN cord-018437-yjvwa1ot 219 10 localized localized JJ cord-018437-yjvwa1ot 219 11 infection infection NN cord-018437-yjvwa1ot 219 12 of of IN cord-018437-yjvwa1ot 219 13 virtually virtually RB cord-018437-yjvwa1ot 219 14 all all DT cord-018437-yjvwa1ot 219 15 organ organ NN cord-018437-yjvwa1ot 219 16 systems system NNS cord-018437-yjvwa1ot 219 17 , , , cord-018437-yjvwa1ot 219 18 although although IN cord-018437-yjvwa1ot 219 19 the the DT cord-018437-yjvwa1ot 219 20 hostcell hostcell NNP cord-018437-yjvwa1ot 219 21 range range NN cord-018437-yjvwa1ot 219 22 and and CC cord-018437-yjvwa1ot 219 23 typical typical JJ cord-018437-yjvwa1ot 219 24 disease disease NN cord-018437-yjvwa1ot 219 25 characteristics characteristic NNS cord-018437-yjvwa1ot 219 26 vary vary VBP cord-018437-yjvwa1ot 219 27 by by IN cord-018437-yjvwa1ot 219 28 species specie NNS cord-018437-yjvwa1ot 219 29 . . . cord-018437-yjvwa1ot 220 1 A a DT cord-018437-yjvwa1ot 220 2 characteristic characteristic NN cord-018437-yjvwa1ot 220 3 of of IN cord-018437-yjvwa1ot 220 4 herpesvirus herpesvirus NN cord-018437-yjvwa1ot 220 5 infections infection NNS cord-018437-yjvwa1ot 220 6 is be VBZ cord-018437-yjvwa1ot 220 7 latency latency NN cord-018437-yjvwa1ot 220 8 , , , cord-018437-yjvwa1ot 220 9 which which WDT cord-018437-yjvwa1ot 220 10 is be VBZ cord-018437-yjvwa1ot 220 11 commonly commonly RB cord-018437-yjvwa1ot 220 12 associated associate VBN cord-018437-yjvwa1ot 220 13 with with IN cord-018437-yjvwa1ot 220 14 reactivation reactivation NN cord-018437-yjvwa1ot 220 15 and and CC cord-018437-yjvwa1ot 220 16 symptomatic symptomatic JJ cord-018437-yjvwa1ot 220 17 infections infection NNS cord-018437-yjvwa1ot 220 18 ( ( -LRB- cord-018437-yjvwa1ot 220 19 e.g. e.g. RB cord-018437-yjvwa1ot 220 20 , , , cord-018437-yjvwa1ot 220 21 shingles shingle NNS cord-018437-yjvwa1ot 220 22 ) ) -RRB- cord-018437-yjvwa1ot 220 23 . . . cord-018437-yjvwa1ot 221 1 While while IN cord-018437-yjvwa1ot 221 2 active active JJ cord-018437-yjvwa1ot 221 3 infection infection NN cord-018437-yjvwa1ot 221 4 with with IN cord-018437-yjvwa1ot 221 5 herpesviruses herpesviruses NNP cord-018437-yjvwa1ot 221 6 results result NNS cord-018437-yjvwa1ot 221 7 in in IN cord-018437-yjvwa1ot 221 8 the the DT cord-018437-yjvwa1ot 221 9 destruction destruction NN cord-018437-yjvwa1ot 221 10 of of IN cord-018437-yjvwa1ot 221 11 the the DT cord-018437-yjvwa1ot 221 12 infected infected JJ cord-018437-yjvwa1ot 221 13 host host NN cord-018437-yjvwa1ot 221 14 cell cell NN cord-018437-yjvwa1ot 221 15 , , , cord-018437-yjvwa1ot 221 16 latently latently RB cord-018437-yjvwa1ot 221 17 infected infected JJ cord-018437-yjvwa1ot 221 18 cells cell NNS cord-018437-yjvwa1ot 221 19 remain remain VBP cord-018437-yjvwa1ot 221 20 viable viable JJ cord-018437-yjvwa1ot 221 21 . . . cord-018437-yjvwa1ot 222 1 In in IN cord-018437-yjvwa1ot 222 2 latently latently RB cord-018437-yjvwa1ot 222 3 infected infect VBN cord-018437-yjvwa1ot 222 4 cells cell NNS cord-018437-yjvwa1ot 222 5 , , , cord-018437-yjvwa1ot 222 6 the the DT cord-018437-yjvwa1ot 222 7 viral viral JJ cord-018437-yjvwa1ot 222 8 genome genome NN cord-018437-yjvwa1ot 222 9 forms form NNS cord-018437-yjvwa1ot 222 10 circularized circularize VBN cord-018437-yjvwa1ot 222 11 molecules molecule NNS cord-018437-yjvwa1ot 222 12 within within IN cord-018437-yjvwa1ot 222 13 the the DT cord-018437-yjvwa1ot 222 14 host host NN cord-018437-yjvwa1ot 222 15 nucleus nucleus NN cord-018437-yjvwa1ot 222 16 with with IN cord-018437-yjvwa1ot 222 17 limited limited JJ cord-018437-yjvwa1ot 222 18 expression expression NN cord-018437-yjvwa1ot 222 19 of of IN cord-018437-yjvwa1ot 222 20 viral viral JJ cord-018437-yjvwa1ot 222 21 genes gene NNS cord-018437-yjvwa1ot 222 22 . . . cord-018437-yjvwa1ot 223 1 ( ( -LRB- cord-018437-yjvwa1ot 223 2 Gompels Gompels NNP cord-018437-yjvwa1ot 223 3 et et NNP cord-018437-yjvwa1ot 223 4 al al NNP cord-018437-yjvwa1ot 223 5 . . NNP cord-018437-yjvwa1ot 223 6 1995 1995 CD cord-018437-yjvwa1ot 223 7 ) ) -RRB- cord-018437-yjvwa1ot 223 8 of of IN cord-018437-yjvwa1ot 223 9 these these DT cord-018437-yjvwa1ot 223 10 viruses virus NNS cord-018437-yjvwa1ot 223 11 has have VBZ cord-018437-yjvwa1ot 223 12 the the DT cord-018437-yjvwa1ot 223 13 simplest simple JJS cord-018437-yjvwa1ot 223 14 organization organization NN cord-018437-yjvwa1ot 223 15 and and CC cord-018437-yjvwa1ot 223 16 lowest low JJS cord-018437-yjvwa1ot 223 17 % % NN cord-018437-yjvwa1ot 223 18 G g NN cord-018437-yjvwa1ot 223 19 + + CC cord-018437-yjvwa1ot 223 20 C c NN cord-018437-yjvwa1ot 223 21 content content NN cord-018437-yjvwa1ot 223 22 compared compare VBN cord-018437-yjvwa1ot 223 23 to to IN cord-018437-yjvwa1ot 223 24 the the DT cord-018437-yjvwa1ot 223 25 other other JJ cord-018437-yjvwa1ot 223 26 herpesviruses herpesviruse NNS cord-018437-yjvwa1ot 223 27 . . . cord-018437-yjvwa1ot 224 1 Reading read VBG cord-018437-yjvwa1ot 224 2 frames frame NNS cord-018437-yjvwa1ot 224 3 are be VBP cord-018437-yjvwa1ot 224 4 present present JJ cord-018437-yjvwa1ot 224 5 on on IN cord-018437-yjvwa1ot 224 6 each each DT cord-018437-yjvwa1ot 224 7 strand strand NN cord-018437-yjvwa1ot 224 8 of of IN cord-018437-yjvwa1ot 224 9 the the DT cord-018437-yjvwa1ot 224 10 dsDNA dsdna NN cord-018437-yjvwa1ot 224 11 . . . cord-018437-yjvwa1ot 225 1 Core core NN cord-018437-yjvwa1ot 225 2 herpesvirus herpesvirus NN cord-018437-yjvwa1ot 225 3 proteins protein NNS cord-018437-yjvwa1ot 225 4 are be VBP cord-018437-yjvwa1ot 225 5 clustered cluster VBN cord-018437-yjvwa1ot 225 6 near near IN cord-018437-yjvwa1ot 225 7 the the DT cord-018437-yjvwa1ot 225 8 center center NN cord-018437-yjvwa1ot 225 9 of of IN cord-018437-yjvwa1ot 225 10 the the DT cord-018437-yjvwa1ot 225 11 strands strand NNS cord-018437-yjvwa1ot 225 12 , , , cord-018437-yjvwa1ot 225 13 while while IN cord-018437-yjvwa1ot 225 14 species specie NNS cord-018437-yjvwa1ot 225 15 - - HYPH cord-018437-yjvwa1ot 225 16 specifi specifi NN cord-018437-yjvwa1ot 225 17 c c NN cord-018437-yjvwa1ot 225 18 genes gene NNS cord-018437-yjvwa1ot 225 19 are be VBP cord-018437-yjvwa1ot 225 20 located locate VBN cord-018437-yjvwa1ot 225 21 toward toward IN cord-018437-yjvwa1ot 225 22 the the DT cord-018437-yjvwa1ot 225 23 ends end NNS cord-018437-yjvwa1ot 225 24 of of IN cord-018437-yjvwa1ot 225 25 the the DT cord-018437-yjvwa1ot 225 26 strands strand NNS cord-018437-yjvwa1ot 226 1 ( ( -LRB- cord-018437-yjvwa1ot 226 2 Braun Braun NNP cord-018437-yjvwa1ot 226 3 et et NNP cord-018437-yjvwa1ot 226 4 al al NNP cord-018437-yjvwa1ot 226 5 . . . cord-018437-yjvwa1ot 226 6 1997 1997 CD cord-018437-yjvwa1ot 226 7 ) ) -RRB- cord-018437-yjvwa1ot 226 8 . . . cord-018437-yjvwa1ot 227 1 HHV-6 HHV-6 NNP cord-018437-yjvwa1ot 227 2 and and CC cord-018437-yjvwa1ot 227 3 HHV-7 HHV-7 NNP cord-018437-yjvwa1ot 227 4 are be VBP cord-018437-yjvwa1ot 227 5 assigned assign VBN cord-018437-yjvwa1ot 227 6 to to IN cord-018437-yjvwa1ot 227 7 the the DT cord-018437-yjvwa1ot 227 8 genus genus NN cord-018437-yjvwa1ot 227 9 Roseolovirus Roseolovirus NNP cord-018437-yjvwa1ot 227 10 in in IN cord-018437-yjvwa1ot 227 11 the the DT cord-018437-yjvwa1ot 227 12 subfamily subfamily NN cord-018437-yjvwa1ot 227 13 Betaherpesvirinae Betaherpesvirinae NNP cord-018437-yjvwa1ot 227 14 , , , cord-018437-yjvwa1ot 227 15 family family NN cord-018437-yjvwa1ot 227 16 Herpesviridae Herpesviridae NNP cord-018437-yjvwa1ot 227 17 , , , cord-018437-yjvwa1ot 227 18 and and CC cord-018437-yjvwa1ot 227 19 order order VB cord-018437-yjvwa1ot 227 20 Herpesvirales Herpesvirales NNP cord-018437-yjvwa1ot 227 21 . . . cord-018437-yjvwa1ot 228 1 There there EX cord-018437-yjvwa1ot 228 2 are be VBP cord-018437-yjvwa1ot 228 3 two two CD cord-018437-yjvwa1ot 228 4 distinct distinct JJ cord-018437-yjvwa1ot 228 5 HHV-6 HHV-6 NNP cord-018437-yjvwa1ot 228 6 species specie NNS cord-018437-yjvwa1ot 228 7 : : : cord-018437-yjvwa1ot 228 8 Human human JJ cord-018437-yjvwa1ot 228 9 herpesvirus herpesvirus NN cord-018437-yjvwa1ot 228 10 6A 6a CD cord-018437-yjvwa1ot 228 11 ( ( -LRB- cord-018437-yjvwa1ot 228 12 the the DT cord-018437-yjvwa1ot 228 13 Roseolovirus Roseolovirus NNP cord-018437-yjvwa1ot 228 14 type type NN cord-018437-yjvwa1ot 228 15 species specie NNS cord-018437-yjvwa1ot 228 16 ) ) -RRB- cord-018437-yjvwa1ot 228 17 and and CC cord-018437-yjvwa1ot 228 18 Human human JJ cord-018437-yjvwa1ot 228 19 herpesvirus herpesvirus NN cord-018437-yjvwa1ot 228 20 6B 6b CD cord-018437-yjvwa1ot 228 21 . . . cord-018437-yjvwa1ot 229 1 HHV-6B HHV-6B NNP cord-018437-yjvwa1ot 229 2 is be VBZ cord-018437-yjvwa1ot 229 3 the the DT cord-018437-yjvwa1ot 229 4 agent agent NN cord-018437-yjvwa1ot 229 5 of of IN cord-018437-yjvwa1ot 229 6 exanthem exanthem NNP cord-018437-yjvwa1ot 229 7 subitum subitum NNP cord-018437-yjvwa1ot 229 8 . . . cord-018437-yjvwa1ot 230 1 There there EX cord-018437-yjvwa1ot 230 2 is be VBZ cord-018437-yjvwa1ot 230 3 a a DT cord-018437-yjvwa1ot 230 4 single single JJ cord-018437-yjvwa1ot 230 5 HHV-7 HHV-7 NNP cord-018437-yjvwa1ot 230 6 species specie NNS cord-018437-yjvwa1ot 230 7 , , , cord-018437-yjvwa1ot 230 8 Human human JJ cord-018437-yjvwa1ot 230 9 herpesvirus herpesvirus NNP cord-018437-yjvwa1ot 230 10 7 7 CD cord-018437-yjvwa1ot 230 11 , , , cord-018437-yjvwa1ot 230 12 which which WDT cord-018437-yjvwa1ot 230 13 is be VBZ cord-018437-yjvwa1ot 230 14 also also RB cord-018437-yjvwa1ot 230 15 a a DT cord-018437-yjvwa1ot 230 16 cause cause NN cord-018437-yjvwa1ot 230 17 of of IN cord-018437-yjvwa1ot 230 18 exanthem exanthem NNP cord-018437-yjvwa1ot 230 19 subitum subitum NNP cord-018437-yjvwa1ot 230 20 . . . cord-018437-yjvwa1ot 231 1 T t NN cord-018437-yjvwa1ot 231 2 - - HYPH cord-018437-yjvwa1ot 231 3 lymphocytes lymphocyte NNS cord-018437-yjvwa1ot 231 4 are be VBP cord-018437-yjvwa1ot 231 5 the the DT cord-018437-yjvwa1ot 231 6 primary primary JJ cord-018437-yjvwa1ot 231 7 target target NN cord-018437-yjvwa1ot 231 8 cell cell NN cord-018437-yjvwa1ot 231 9 of of IN cord-018437-yjvwa1ot 231 10 HHV-6 HHV-6 NNP cord-018437-yjvwa1ot 231 11 and and CC cord-018437-yjvwa1ot 231 12 HHV-7 HHV-7 NNP cord-018437-yjvwa1ot 231 13 viruses virus NNS cord-018437-yjvwa1ot 231 14 . . . cord-018437-yjvwa1ot 232 1 • • NNP cord-018437-yjvwa1ot 233 1 Kaposi Kaposi NNP cord-018437-yjvwa1ot 233 2 's 's POS cord-018437-yjvwa1ot 233 3 Sarcoma Sarcoma NNP cord-018437-yjvwa1ot 233 4 - - HYPH cord-018437-yjvwa1ot 233 5 Associated Associated NNP cord-018437-yjvwa1ot 233 6 Herpesvirus Herpesvirus NNP cord-018437-yjvwa1ot 233 7 : : : cord-018437-yjvwa1ot 234 1 The the DT cord-018437-yjvwa1ot 234 2 complete complete JJ cord-018437-yjvwa1ot 234 3 virions virion NNS cord-018437-yjvwa1ot 234 4 of of IN cord-018437-yjvwa1ot 234 5 Kaposi Kaposi NNP cord-018437-yjvwa1ot 234 6 's 's POS cord-018437-yjvwa1ot 234 7 sarcoma sarcoma NN cord-018437-yjvwa1ot 234 8 - - HYPH cord-018437-yjvwa1ot 234 9 associated associate VBN cord-018437-yjvwa1ot 234 10 herpesvirus herpesvirus NN cord-018437-yjvwa1ot 234 11 ( ( -LRB- cord-018437-yjvwa1ot 234 12 KSHV KSHV NNP cord-018437-yjvwa1ot 234 13 ) ) -RRB- cord-018437-yjvwa1ot 234 14 have have VB cord-018437-yjvwa1ot 234 15 a a DT cord-018437-yjvwa1ot 234 16 diameter diameter NN cord-018437-yjvwa1ot 235 1 ~100 ~100 NFP cord-018437-yjvwa1ot 235 2 nm nm NN cord-018437-yjvwa1ot 235 3 . . . cord-018437-yjvwa1ot 236 1 In in IN cord-018437-yjvwa1ot 236 2 addition addition NN cord-018437-yjvwa1ot 236 3 to to IN cord-018437-yjvwa1ot 236 4 virusspecifi virusspecifi NNP cord-018437-yjvwa1ot 236 5 c c NNP cord-018437-yjvwa1ot 236 6 proteins protein NNS cord-018437-yjvwa1ot 236 7 , , , cord-018437-yjvwa1ot 236 8 the the DT cord-018437-yjvwa1ot 236 9 tegument tegument NN cord-018437-yjvwa1ot 236 10 also also RB cord-018437-yjvwa1ot 236 11 carries carry VBZ cord-018437-yjvwa1ot 236 12 viral viral JJ cord-018437-yjvwa1ot 236 13 mRNAs mRNAs NNPS cord-018437-yjvwa1ot 236 14 , , , cord-018437-yjvwa1ot 236 15 probably probably RB cord-018437-yjvwa1ot 236 16 the the DT cord-018437-yjvwa1ot 236 17 result result NN cord-018437-yjvwa1ot 236 18 of of IN cord-018437-yjvwa1ot 236 19 passive passive JJ cord-018437-yjvwa1ot 236 20 incorporation incorporation NN cord-018437-yjvwa1ot 236 21 during during IN cord-018437-yjvwa1ot 236 22 the the DT cord-018437-yjvwa1ot 236 23 cytoplasmic cytoplasmic JJ cord-018437-yjvwa1ot 236 24 envelopment envelopment NN cord-018437-yjvwa1ot 236 25 process process NN cord-018437-yjvwa1ot 236 26 ( ( -LRB- cord-018437-yjvwa1ot 236 27 Bechtel Bechtel NNP cord-018437-yjvwa1ot 236 28 et et NNP cord-018437-yjvwa1ot 236 29 al al NNP cord-018437-yjvwa1ot 236 30 . . NNP cord-018437-yjvwa1ot 236 31 2005 2005 CD cord-018437-yjvwa1ot 236 32 ) ) -RRB- cord-018437-yjvwa1ot 236 33 . . . cord-018437-yjvwa1ot 237 1 The the DT cord-018437-yjvwa1ot 237 2 envelopes envelope NNS cord-018437-yjvwa1ot 237 3 of of IN cord-018437-yjvwa1ot 237 4 complete complete JJ cord-018437-yjvwa1ot 237 5 virions virion NNS cord-018437-yjvwa1ot 237 6 bear bear VBP cord-018437-yjvwa1ot 237 7 KSHV KSHV NNP cord-018437-yjvwa1ot 237 8 - - HYPH cord-018437-yjvwa1ot 237 9 specifi specifi NNP cord-018437-yjvwa1ot 237 10 c c NN cord-018437-yjvwa1ot 237 11 glycoproteins glycoprotein NNS cord-018437-yjvwa1ot 237 12 . . . cord-018437-yjvwa1ot 238 1 The the DT cord-018437-yjvwa1ot 238 2 genome genome NN cord-018437-yjvwa1ot 238 3 ( ( -LRB- cord-018437-yjvwa1ot 238 4 ~170 ~170 NNP cord-018437-yjvwa1ot 238 5 kbp kbp NNP cord-018437-yjvwa1ot 238 6 ) ) -RRB- cord-018437-yjvwa1ot 238 7 has have VBZ cord-018437-yjvwa1ot 238 8 class class NN cord-018437-yjvwa1ot 238 9 C c NN cord-018437-yjvwa1ot 238 10 organization organization NN cord-018437-yjvwa1ot 238 11 ( ( -LRB- cord-018437-yjvwa1ot 238 12 Russo Russo NNP cord-018437-yjvwa1ot 238 13 et et FW cord-018437-yjvwa1ot 238 14 al al NNP cord-018437-yjvwa1ot 238 15 . . . cord-018437-yjvwa1ot 238 16 1996 1996 CD cord-018437-yjvwa1ot 238 17 ) ) -RRB- cord-018437-yjvwa1ot 238 18 typical typical JJ cord-018437-yjvwa1ot 238 19 of of IN cord-018437-yjvwa1ot 238 20 Gammaherpesvirinae Gammaherpesvirinae NNP cord-018437-yjvwa1ot 238 21 . . . cord-018437-yjvwa1ot 239 1 The the DT cord-018437-yjvwa1ot 239 2 conserved conserved JJ cord-018437-yjvwa1ot 239 3 herpesvirus herpesvirus NN cord-018437-yjvwa1ot 239 4 genes gene NNS cord-018437-yjvwa1ot 239 5 are be VBP cord-018437-yjvwa1ot 239 6 clustered cluster VBN cord-018437-yjvwa1ot 239 7 in in IN cord-018437-yjvwa1ot 239 8 four four CD cord-018437-yjvwa1ot 239 9 blocks block NNS cord-018437-yjvwa1ot 239 10 ; ; : cord-018437-yjvwa1ot 239 11 KSHV KSHV NNP cord-018437-yjvwa1ot 239 12 - - HYPH cord-018437-yjvwa1ot 239 13 specifi specifi NNP cord-018437-yjvwa1ot 239 14 c c NN cord-018437-yjvwa1ot 239 15 genes gene NNS cord-018437-yjvwa1ot 239 16 are be VBP cord-018437-yjvwa1ot 239 17 typically typically RB cord-018437-yjvwa1ot 239 18 distributed distribute VBN cord-018437-yjvwa1ot 239 19 in in IN cord-018437-yjvwa1ot 239 20 the the DT cord-018437-yjvwa1ot 239 21 regions region NNS cord-018437-yjvwa1ot 239 22 outside outside RB cord-018437-yjvwa1ot 239 23 and and CC cord-018437-yjvwa1ot 239 24 between between IN cord-018437-yjvwa1ot 239 25 these these DT cord-018437-yjvwa1ot 239 26 blocks block NNS cord-018437-yjvwa1ot 240 1 ( ( -LRB- cord-018437-yjvwa1ot 240 2 Renne Renne NNP cord-018437-yjvwa1ot 240 3 et et NNP cord-018437-yjvwa1ot 240 4 al al NNP cord-018437-yjvwa1ot 240 5 . . . cord-018437-yjvwa1ot 240 6 1996 1996 CD cord-018437-yjvwa1ot 240 7 ) ) -RRB- cord-018437-yjvwa1ot 240 8 . . . cord-018437-yjvwa1ot 241 1 The the DT cord-018437-yjvwa1ot 241 2 KSHV KSHV NNP cord-018437-yjvwa1ot 241 3 species specie NNS cord-018437-yjvwa1ot 241 4 designation designation NN cord-018437-yjvwa1ot 241 5 is be VBZ cord-018437-yjvwa1ot 241 6 Human human JJ cord-018437-yjvwa1ot 241 7 herpesvirus herpesvirus NNP cord-018437-yjvwa1ot 241 8 8 8 CD cord-018437-yjvwa1ot 241 9 , , , cord-018437-yjvwa1ot 241 10 which which WDT cord-018437-yjvwa1ot 241 11 is be VBZ cord-018437-yjvwa1ot 241 12 assigned assign VBN cord-018437-yjvwa1ot 241 13 to to IN cord-018437-yjvwa1ot 241 14 the the DT cord-018437-yjvwa1ot 241 15 genus genus NN cord-018437-yjvwa1ot 241 16 Rhadinovirus Rhadinovirus NNP cord-018437-yjvwa1ot 241 17 within within IN cord-018437-yjvwa1ot 241 18 the the DT cord-018437-yjvwa1ot 241 19 subfamily subfamily NN cord-018437-yjvwa1ot 241 20 Gammaherpesvirinae Gammaherpesvirinae NNP cord-018437-yjvwa1ot 241 21 . . . cord-018437-yjvwa1ot 242 1 The the DT cord-018437-yjvwa1ot 242 2 virus virus NN cord-018437-yjvwa1ot 242 3 has have VBZ cord-018437-yjvwa1ot 242 4 tropism tropism NN cord-018437-yjvwa1ot 242 5 for for IN cord-018437-yjvwa1ot 242 6 B b NN cord-018437-yjvwa1ot 242 7 - - HYPH cord-018437-yjvwa1ot 242 8 lymphocytes lymphocyte NNS cord-018437-yjvwa1ot 242 9 and and CC cord-018437-yjvwa1ot 242 10 is be VBZ cord-018437-yjvwa1ot 242 11 implicated implicate VBN cord-018437-yjvwa1ot 242 12 in in IN cord-018437-yjvwa1ot 242 13 all all DT cord-018437-yjvwa1ot 242 14 forms form NNS cord-018437-yjvwa1ot 242 15 of of IN cord-018437-yjvwa1ot 242 16 Kaposi Kaposi NNP cord-018437-yjvwa1ot 242 17 's 's POS cord-018437-yjvwa1ot 242 18 sarcoma sarcoma NN cord-018437-yjvwa1ot 242 19 . . . cord-018437-yjvwa1ot 243 1 Four four CD cord-018437-yjvwa1ot 243 2 clades clade NNS cord-018437-yjvwa1ot 243 3 , , , cord-018437-yjvwa1ot 243 4 A A NNP cord-018437-yjvwa1ot 243 5 - - HYPH cord-018437-yjvwa1ot 243 6 D D NNP cord-018437-yjvwa1ot 243 7 , , , cord-018437-yjvwa1ot 243 8 with with IN cord-018437-yjvwa1ot 243 9 distinctive distinctive JJ cord-018437-yjvwa1ot 243 10 geographical geographical JJ cord-018437-yjvwa1ot 243 11 distributions distribution NNS cord-018437-yjvwa1ot 243 12 , , , cord-018437-yjvwa1ot 243 13 have have VBP cord-018437-yjvwa1ot 243 14 been be VBN cord-018437-yjvwa1ot 243 15 identifi identifi VBN cord-018437-yjvwa1ot 243 16 ed ed NNP cord-018437-yjvwa1ot 243 17 by by IN cord-018437-yjvwa1ot 243 18 genotypic genotypic JJ cord-018437-yjvwa1ot 243 19 analysis analysis NN cord-018437-yjvwa1ot 243 20 ; ; : cord-018437-yjvwa1ot 243 21 the the DT cord-018437-yjvwa1ot 243 22 A A NNP cord-018437-yjvwa1ot 243 23 and and CC cord-018437-yjvwa1ot 243 24 C c NN cord-018437-yjvwa1ot 243 25 clades clade NNS cord-018437-yjvwa1ot 243 26 cluster cluster VBP cord-018437-yjvwa1ot 243 27 together together RB cord-018437-yjvwa1ot 243 28 and and CC cord-018437-yjvwa1ot 243 29 are be VBP cord-018437-yjvwa1ot 243 30 most most RBS cord-018437-yjvwa1ot 243 31 typical typical JJ cord-018437-yjvwa1ot 243 32 for for IN cord-018437-yjvwa1ot 243 33 isolates isolate NNS cord-018437-yjvwa1ot 243 34 from from IN cord-018437-yjvwa1ot 243 35 Europe Europe NNP cord-018437-yjvwa1ot 243 36 and and CC cord-018437-yjvwa1ot 243 37 the the DT cord-018437-yjvwa1ot 243 38 United United NNP cord-018437-yjvwa1ot 243 39 States States NNP cord-018437-yjvwa1ot 243 40 . . . cord-018437-yjvwa1ot 244 1 • • NNP cord-018437-yjvwa1ot 245 1 Varicella varicella NN cord-018437-yjvwa1ot 245 2 - - HYPH cord-018437-yjvwa1ot 245 3 Zoster Zoster NNP cord-018437-yjvwa1ot 245 4 Virus virus NN cord-018437-yjvwa1ot 245 5 ( ( -LRB- cord-018437-yjvwa1ot 245 6 VZV VZV NNP cord-018437-yjvwa1ot 245 7 ) ) -RRB- cord-018437-yjvwa1ot 245 8 : : : cord-018437-yjvwa1ot 245 9 The the DT cord-018437-yjvwa1ot 245 10 dense dense JJ cord-018437-yjvwa1ot 245 11 core core NN cord-018437-yjvwa1ot 245 12 of of IN cord-018437-yjvwa1ot 245 13 VZV VZV NNP cord-018437-yjvwa1ot 245 14 is be VBZ cord-018437-yjvwa1ot 245 15 enclosed enclose VBN cord-018437-yjvwa1ot 245 16 in in IN cord-018437-yjvwa1ot 245 17 an an DT cord-018437-yjvwa1ot 245 18 icosahedral icosahedral JJ cord-018437-yjvwa1ot 245 19 capsid capsid NN cord-018437-yjvwa1ot 245 20 ( ( -LRB- cord-018437-yjvwa1ot 245 21 80 80 CD cord-018437-yjvwa1ot 245 22 - - SYM cord-018437-yjvwa1ot 245 23 120 120 CD cord-018437-yjvwa1ot 245 24 nm nm NN cord-018437-yjvwa1ot 245 25 diameter diameter NN cord-018437-yjvwa1ot 245 26 ) ) -RRB- cord-018437-yjvwa1ot 245 27 , , , cord-018437-yjvwa1ot 245 28 which which WDT cord-018437-yjvwa1ot 245 29 is be VBZ cord-018437-yjvwa1ot 245 30 surrounded surround VBN cord-018437-yjvwa1ot 245 31 by by IN cord-018437-yjvwa1ot 245 32 an an DT cord-018437-yjvwa1ot 245 33 amorphous amorphous JJ cord-018437-yjvwa1ot 245 34 tegument tegument NN cord-018437-yjvwa1ot 245 35 . . . cord-018437-yjvwa1ot 246 1 The the DT cord-018437-yjvwa1ot 246 2 envelope envelope NN cord-018437-yjvwa1ot 246 3 may may MD cord-018437-yjvwa1ot 246 4 be be VB cord-018437-yjvwa1ot 246 5 derived derive VBN cord-018437-yjvwa1ot 246 6 from from IN cord-018437-yjvwa1ot 246 7 multiple multiple JJ cord-018437-yjvwa1ot 246 8 types type NNS cord-018437-yjvwa1ot 246 9 of of IN cord-018437-yjvwa1ot 246 10 hostcell hostcell NNP cord-018437-yjvwa1ot 246 11 membranes membrane NNS cord-018437-yjvwa1ot 246 12 during during IN cord-018437-yjvwa1ot 246 13 transit transit NN cord-018437-yjvwa1ot 246 14 from from IN cord-018437-yjvwa1ot 246 15 the the DT cord-018437-yjvwa1ot 246 16 nucleus nucleus NN cord-018437-yjvwa1ot 246 17 through through IN cord-018437-yjvwa1ot 246 18 the the DT cord-018437-yjvwa1ot 246 19 cytoplasm cytoplasm NN cord-018437-yjvwa1ot 246 20 ; ; : cord-018437-yjvwa1ot 246 21 specifi specifi NNP cord-018437-yjvwa1ot 246 22 c c NNP cord-018437-yjvwa1ot 246 23 viralencoded viralencoded JJ cord-018437-yjvwa1ot 246 24 glycoproteins glycoprotein NNS cord-018437-yjvwa1ot 246 25 are be VBP cord-018437-yjvwa1ot 246 26 embedded embed VBN cord-018437-yjvwa1ot 246 27 in in IN cord-018437-yjvwa1ot 246 28 the the DT cord-018437-yjvwa1ot 246 29 envelope envelope NN cord-018437-yjvwa1ot 246 30 of of IN cord-018437-yjvwa1ot 246 31 the the DT cord-018437-yjvwa1ot 246 32 complete complete JJ cord-018437-yjvwa1ot 246 33 virions virion NNS cord-018437-yjvwa1ot 246 34 , , , cord-018437-yjvwa1ot 246 35 which which WDT cord-018437-yjvwa1ot 246 36 may may MD cord-018437-yjvwa1ot 246 37 be be VB cord-018437-yjvwa1ot 246 38 spherical spherical JJ cord-018437-yjvwa1ot 246 39 or or CC cord-018437-yjvwa1ot 246 40 pleomorphic pleomorphic JJ cord-018437-yjvwa1ot 246 41 ( ( -LRB- cord-018437-yjvwa1ot 246 42 180 180 CD cord-018437-yjvwa1ot 246 43 - - SYM cord-018437-yjvwa1ot 246 44 200 200 CD cord-018437-yjvwa1ot 246 45 nm nm NN cord-018437-yjvwa1ot 246 46 in in IN cord-018437-yjvwa1ot 246 47 diameter diameter NN cord-018437-yjvwa1ot 246 48 ) ) -RRB- cord-018437-yjvwa1ot 246 49 . . . cord-018437-yjvwa1ot 247 1 VZV VZV NNP cord-018437-yjvwa1ot 247 2 has have VBZ cord-018437-yjvwa1ot 247 3 a a DT cord-018437-yjvwa1ot 247 4 class class NN cord-018437-yjvwa1ot 247 5 D d NN cord-018437-yjvwa1ot 247 6 dsDNA dsdna NN cord-018437-yjvwa1ot 247 7 genome genome NN cord-018437-yjvwa1ot 247 8 ( ( -LRB- cord-018437-yjvwa1ot 247 9 ~125 ~125 NNP cord-018437-yjvwa1ot 247 10 kbp kbp NNP cord-018437-yjvwa1ot 247 11 ) ) -RRB- cord-018437-yjvwa1ot 248 1 ( ( -LRB- cord-018437-yjvwa1ot 248 2 Clarke Clarke NNP cord-018437-yjvwa1ot 248 3 et et NNP cord-018437-yjvwa1ot 248 4 al al NNP cord-018437-yjvwa1ot 248 5 . . . cord-018437-yjvwa1ot 249 1 1995 1995 CD cord-018437-yjvwa1ot 249 2 ; ; : cord-018437-yjvwa1ot 249 3 Davison Davison NNP cord-018437-yjvwa1ot 249 4 1984 1984 CD cord-018437-yjvwa1ot 249 5 ) ) -RRB- cord-018437-yjvwa1ot 249 6 , , , cord-018437-yjvwa1ot 249 7 resulting result VBG cord-018437-yjvwa1ot 249 8 in in IN cord-018437-yjvwa1ot 249 9 production production NN cord-018437-yjvwa1ot 249 10 of of IN cord-018437-yjvwa1ot 249 11 two two CD cord-018437-yjvwa1ot 249 12 isomeric isomeric JJ cord-018437-yjvwa1ot 249 13 genomic genomic JJ cord-018437-yjvwa1ot 249 14 forms form NNS cord-018437-yjvwa1ot 249 15 by by IN cord-018437-yjvwa1ot 249 16 infected infected JJ cord-018437-yjvwa1ot 249 17 cells cell NNS cord-018437-yjvwa1ot 249 18 through through IN cord-018437-yjvwa1ot 249 19 inversion inversion NN cord-018437-yjvwa1ot 249 20 of of IN cord-018437-yjvwa1ot 249 21 the the DT cord-018437-yjvwa1ot 249 22 US US NNP cord-018437-yjvwa1ot 249 23 region region NN cord-018437-yjvwa1ot 249 24 ( ( -LRB- cord-018437-yjvwa1ot 249 25 Ecker Ecker NNP cord-018437-yjvwa1ot 249 26 and and CC cord-018437-yjvwa1ot 249 27 Hyman Hyman NNP cord-018437-yjvwa1ot 249 28 1982 1982 CD cord-018437-yjvwa1ot 249 29 ) ) -RRB- cord-018437-yjvwa1ot 249 30 . . . cord-018437-yjvwa1ot 250 1 The the DT cord-018437-yjvwa1ot 250 2 genome genome NN cord-018437-yjvwa1ot 250 3 encodes encode VBZ cord-018437-yjvwa1ot 250 4 more more JJR cord-018437-yjvwa1ot 250 5 than than IN cord-018437-yjvwa1ot 250 6 70 70 CD cord-018437-yjvwa1ot 250 7 proteins protein NNS cord-018437-yjvwa1ot 250 8 . . . cord-018437-yjvwa1ot 251 1 The the DT cord-018437-yjvwa1ot 251 2 organization organization NN cord-018437-yjvwa1ot 251 3 includes include VBZ cord-018437-yjvwa1ot 251 4 grouping group VBG cord-018437-yjvwa1ot 251 5 of of IN cord-018437-yjvwa1ot 251 6 several several JJ cord-018437-yjvwa1ot 251 7 genes gene NNS cord-018437-yjvwa1ot 251 8 into into IN cord-018437-yjvwa1ot 251 9 single single JJ cord-018437-yjvwa1ot 251 10 transcription transcription NN cord-018437-yjvwa1ot 251 11 units unit NNS cord-018437-yjvwa1ot 251 12 , , , cord-018437-yjvwa1ot 251 13 genes gene NNS cord-018437-yjvwa1ot 251 14 with with IN cord-018437-yjvwa1ot 251 15 overlapping overlap VBG cord-018437-yjvwa1ot 251 16 reading reading NN cord-018437-yjvwa1ot 251 17 frames frame NNS cord-018437-yjvwa1ot 251 18 , , , cord-018437-yjvwa1ot 251 19 and and CC cord-018437-yjvwa1ot 251 20 spliced splice VBN cord-018437-yjvwa1ot 251 21 segments segment NNS cord-018437-yjvwa1ot 251 22 ( ( -LRB- cord-018437-yjvwa1ot 251 23 Davison Davison NNP cord-018437-yjvwa1ot 251 24 and and CC cord-018437-yjvwa1ot 251 25 Scott Scott NNP cord-018437-yjvwa1ot 251 26 1986 1986 CD cord-018437-yjvwa1ot 251 27 ) ) -RRB- cord-018437-yjvwa1ot 251 28 . . . cord-018437-yjvwa1ot 252 1 The the DT cord-018437-yjvwa1ot 252 2 species specie NNS cord-018437-yjvwa1ot 252 3 designation designation NN cord-018437-yjvwa1ot 252 4 for for IN cord-018437-yjvwa1ot 252 5 VZV VZV NNP cord-018437-yjvwa1ot 252 6 is be VBZ cord-018437-yjvwa1ot 252 7 Human human JJ cord-018437-yjvwa1ot 252 8 herpesvirus herpesvirus NN cord-018437-yjvwa1ot 252 9 3 3 CD cord-018437-yjvwa1ot 252 10 . . . cord-018437-yjvwa1ot 253 1 It -PRON- PRP cord-018437-yjvwa1ot 253 2 is be VBZ cord-018437-yjvwa1ot 253 3 the the DT cord-018437-yjvwa1ot 253 4 type type NN cord-018437-yjvwa1ot 253 5 species specie NNS cord-018437-yjvwa1ot 253 6 of of IN cord-018437-yjvwa1ot 253 7 the the DT cord-018437-yjvwa1ot 253 8 genus genus NN cord-018437-yjvwa1ot 253 9 Varicellovirus Varicellovirus NNP cord-018437-yjvwa1ot 253 10 within within IN cord-018437-yjvwa1ot 253 11 the the DT cord-018437-yjvwa1ot 253 12 subfamily subfamily NN cord-018437-yjvwa1ot 253 13 Alphaherpesvirinae Alphaherpesvirinae NNP cord-018437-yjvwa1ot 253 14 . . . cord-018437-yjvwa1ot 254 1 There there EX cord-018437-yjvwa1ot 254 2 is be VBZ cord-018437-yjvwa1ot 254 3 only only RB cord-018437-yjvwa1ot 254 4 a a DT cord-018437-yjvwa1ot 254 5 single single JJ cord-018437-yjvwa1ot 254 6 serotype serotype NN cord-018437-yjvwa1ot 254 7 of of IN cord-018437-yjvwa1ot 254 8 VZV VZV NNP cord-018437-yjvwa1ot 254 9 . . . cord-018437-yjvwa1ot 255 1 For for IN cord-018437-yjvwa1ot 255 2 epidemiologic epidemiologic JJ cord-018437-yjvwa1ot 255 3 purposes purpose NNS cord-018437-yjvwa1ot 255 4 , , , cord-018437-yjvwa1ot 255 5 VZV VZV NNP cord-018437-yjvwa1ot 255 6 isolates isolate NNS cord-018437-yjvwa1ot 255 7 may may MD cord-018437-yjvwa1ot 255 8 be be VB cord-018437-yjvwa1ot 255 9 genotyped genotype VBN cord-018437-yjvwa1ot 255 10 on on IN cord-018437-yjvwa1ot 255 11 the the DT cord-018437-yjvwa1ot 255 12 basis basis NN cord-018437-yjvwa1ot 255 13 of of IN cord-018437-yjvwa1ot 255 14 minor minor JJ cord-018437-yjvwa1ot 255 15 differences difference NNS cord-018437-yjvwa1ot 255 16 in in IN cord-018437-yjvwa1ot 255 17 DNA dna NN cord-018437-yjvwa1ot 255 18 sequence sequence NN cord-018437-yjvwa1ot 255 19 ; ; : cord-018437-yjvwa1ot 255 20 different different JJ cord-018437-yjvwa1ot 255 21 genotypes genotype NNS cord-018437-yjvwa1ot 255 22 may may MD cord-018437-yjvwa1ot 255 23 be be VB cord-018437-yjvwa1ot 255 24 classifi classifi NNP cord-018437-yjvwa1ot 255 25 ed ed NN cord-018437-yjvwa1ot 255 26 as as IN cord-018437-yjvwa1ot 255 27 European european JJ cord-018437-yjvwa1ot 255 28 , , , cord-018437-yjvwa1ot 255 29 Japanese Japanese NNPS cord-018437-yjvwa1ot 255 30 , , , cord-018437-yjvwa1ot 255 31 or or CC cord-018437-yjvwa1ot 255 32 Mosaic Mosaic NNP cord-018437-yjvwa1ot 256 1 ( ( -LRB- cord-018437-yjvwa1ot 256 2 Loparev Loparev NNP cord-018437-yjvwa1ot 256 3 et et NNP cord-018437-yjvwa1ot 256 4 al al NNP cord-018437-yjvwa1ot 256 5 . . . cord-018437-yjvwa1ot 256 6 2004 2004 CD cord-018437-yjvwa1ot 256 7 ) ) -RRB- cord-018437-yjvwa1ot 256 8 . . . cord-018437-yjvwa1ot 257 1 The the DT cord-018437-yjvwa1ot 257 2 host host NN cord-018437-yjvwa1ot 257 3 range range NN cord-018437-yjvwa1ot 257 4 of of IN cord-018437-yjvwa1ot 257 5 VZV VZV NNP cord-018437-yjvwa1ot 257 6 is be VBZ cord-018437-yjvwa1ot 257 7 restricted restrict VBN cord-018437-yjvwa1ot 257 8 to to IN cord-018437-yjvwa1ot 257 9 cells cell NNS cord-018437-yjvwa1ot 257 10 of of IN cord-018437-yjvwa1ot 257 11 humans human NNS cord-018437-yjvwa1ot 257 12 or or CC cord-018437-yjvwa1ot 257 13 other other JJ cord-018437-yjvwa1ot 257 14 primates primate NNS cord-018437-yjvwa1ot 257 15 ; ; : cord-018437-yjvwa1ot 257 16 in in IN cord-018437-yjvwa1ot 257 17 humans human NNS cord-018437-yjvwa1ot 257 18 , , , cord-018437-yjvwa1ot 257 19 VZV VZV NNP cord-018437-yjvwa1ot 257 20 has have VBZ cord-018437-yjvwa1ot 257 21 tropism tropism NN cord-018437-yjvwa1ot 257 22 for for IN cord-018437-yjvwa1ot 257 23 human human JJ cord-018437-yjvwa1ot 257 24 T t NN cord-018437-yjvwa1ot 257 25 - - HYPH cord-018437-yjvwa1ot 257 26 lymphocytes lymphocyte NNS cord-018437-yjvwa1ot 257 27 and and CC cord-018437-yjvwa1ot 257 28 establishes establish VBZ cord-018437-yjvwa1ot 257 29 latent latent JJ cord-018437-yjvwa1ot 257 30 infection infection NN cord-018437-yjvwa1ot 257 31 in in IN cord-018437-yjvwa1ot 257 32 the the DT cord-018437-yjvwa1ot 257 33 cells cell NNS cord-018437-yjvwa1ot 257 34 of of IN cord-018437-yjvwa1ot 257 35 the the DT cord-018437-yjvwa1ot 257 36 dorsal dorsal JJ cord-018437-yjvwa1ot 257 37 root root NN cord-018437-yjvwa1ot 257 38 ganglia ganglion NNS cord-018437-yjvwa1ot 257 39 . . . cord-018437-yjvwa1ot 258 1 Orthomyxoviridae Orthomyxoviridae NNP cord-018437-yjvwa1ot 258 2 : : : cord-018437-yjvwa1ot 259 1 Infl Infl NNP cord-018437-yjvwa1ot 259 2 uenza uenza NN cord-018437-yjvwa1ot 259 3 viruses virus NNS cord-018437-yjvwa1ot 259 4 belong belong VBP cord-018437-yjvwa1ot 259 5 to to IN cord-018437-yjvwa1ot 259 6 the the DT cord-018437-yjvwa1ot 259 7 family family NN cord-018437-yjvwa1ot 259 8 Orthomyxoviridae Orthomyxoviridae NNP cord-018437-yjvwa1ot 259 9 . . . cord-018437-yjvwa1ot 260 1 They -PRON- PRP cord-018437-yjvwa1ot 260 2 are be VBP cord-018437-yjvwa1ot 260 3 polymorphic polymorphic JJ cord-018437-yjvwa1ot 260 4 ; ; : cord-018437-yjvwa1ot 260 5 viruses virus NNS cord-018437-yjvwa1ot 260 6 may may MD cord-018437-yjvwa1ot 260 7 be be VB cord-018437-yjvwa1ot 260 8 spherical spherical JJ cord-018437-yjvwa1ot 260 9 ( ( -LRB- cord-018437-yjvwa1ot 260 10 ~100 ~100 NFP cord-018437-yjvwa1ot 260 11 nm nm NN cord-018437-yjvwa1ot 260 12 diameter diameter NN cord-018437-yjvwa1ot 260 13 ) ) -RRB- cord-018437-yjvwa1ot 260 14 or or CC cord-018437-yjvwa1ot 260 15 fi fi NNP cord-018437-yjvwa1ot 260 16 lamentous lamentous NNP cord-018437-yjvwa1ot 260 17 . . . cord-018437-yjvwa1ot 261 1 Complete complete JJ cord-018437-yjvwa1ot 261 2 virions virion NNS cord-018437-yjvwa1ot 261 3 are be VBP cord-018437-yjvwa1ot 261 4 surrounded surround VBN cord-018437-yjvwa1ot 261 5 by by IN cord-018437-yjvwa1ot 261 6 an an DT cord-018437-yjvwa1ot 261 7 envelope envelope NN cord-018437-yjvwa1ot 261 8 derived derive VBN cord-018437-yjvwa1ot 261 9 from from IN cord-018437-yjvwa1ot 261 10 the the DT cord-018437-yjvwa1ot 261 11 host host NN cord-018437-yjvwa1ot 261 12 cytoplasmic cytoplasmic JJ cord-018437-yjvwa1ot 261 13 membrane membrane NN cord-018437-yjvwa1ot 261 14 . . . cord-018437-yjvwa1ot 262 1 Viral viral JJ cord-018437-yjvwa1ot 262 2 hemagglutinin hemagglutinin NN cord-018437-yjvwa1ot 262 3 and and CC cord-018437-yjvwa1ot 262 4 neuraminidase neuraminidase NN cord-018437-yjvwa1ot 262 5 proteins protein NNS cord-018437-yjvwa1ot 262 6 are be VBP cord-018437-yjvwa1ot 262 7 embedded embed VBN cord-018437-yjvwa1ot 262 8 in in IN cord-018437-yjvwa1ot 262 9 the the DT cord-018437-yjvwa1ot 262 10 envelope envelope NN cord-018437-yjvwa1ot 262 11 resulting result VBG cord-018437-yjvwa1ot 262 12 in in IN cord-018437-yjvwa1ot 262 13 characteristic characteristic JJ cord-018437-yjvwa1ot 262 14 10 10 CD cord-018437-yjvwa1ot 262 15 - - SYM cord-018437-yjvwa1ot 262 16 14 14 CD cord-018437-yjvwa1ot 262 17 nm nm NN cord-018437-yjvwa1ot 262 18 spikes spike NNS cord-018437-yjvwa1ot 262 19 projecting project VBG cord-018437-yjvwa1ot 262 20 from from IN cord-018437-yjvwa1ot 262 21 the the DT cord-018437-yjvwa1ot 262 22 surface surface NN cord-018437-yjvwa1ot 262 23 of of IN cord-018437-yjvwa1ot 262 24 virions virion NNS cord-018437-yjvwa1ot 262 25 . . . cord-018437-yjvwa1ot 263 1 In in IN cord-018437-yjvwa1ot 263 2 addition addition NN cord-018437-yjvwa1ot 263 3 to to IN cord-018437-yjvwa1ot 263 4 the the DT cord-018437-yjvwa1ot 263 5 HA HA NNP cord-018437-yjvwa1ot 263 6 and and CC cord-018437-yjvwa1ot 263 7 NA NA NNP cord-018437-yjvwa1ot 263 8 protein protein NN cord-018437-yjvwa1ot 263 9 , , , cord-018437-yjvwa1ot 263 10 M2 M2 NNP cord-018437-yjvwa1ot 263 11 protein protein NN cord-018437-yjvwa1ot 263 12 is be VBZ cord-018437-yjvwa1ot 263 13 embedded embed VBN cord-018437-yjvwa1ot 263 14 into into IN cord-018437-yjvwa1ot 263 15 the the DT cord-018437-yjvwa1ot 263 16 envelope envelope NN cord-018437-yjvwa1ot 263 17 of of IN cord-018437-yjvwa1ot 263 18 Infl Infl NNP cord-018437-yjvwa1ot 263 19 uenza uenza NNP cord-018437-yjvwa1ot 263 20 A a DT cord-018437-yjvwa1ot 263 21 viruses virus NNS cord-018437-yjvwa1ot 263 22 ; ; : cord-018437-yjvwa1ot 263 23 NB NB NNP cord-018437-yjvwa1ot 263 24 and and CC cord-018437-yjvwa1ot 263 25 BM2 BM2 NNP cord-018437-yjvwa1ot 263 26 proteins protein NNS cord-018437-yjvwa1ot 263 27 are be VBP cord-018437-yjvwa1ot 263 28 embedded embed VBN cord-018437-yjvwa1ot 263 29 into into IN cord-018437-yjvwa1ot 263 30 the the DT cord-018437-yjvwa1ot 263 31 envelopes envelope NNS cord-018437-yjvwa1ot 263 32 of of IN cord-018437-yjvwa1ot 263 33 Infl Infl NNP cord-018437-yjvwa1ot 263 34 uenza uenza NNP cord-018437-yjvwa1ot 263 35 B B NNP cord-018437-yjvwa1ot 263 36 viruses virus NNS cord-018437-yjvwa1ot 263 37 . . . cord-018437-yjvwa1ot 264 1 The the DT cord-018437-yjvwa1ot 264 2 matrix matrix NN cord-018437-yjvwa1ot 264 3 protein protein NN cord-018437-yjvwa1ot 264 4 ( ( -LRB- cord-018437-yjvwa1ot 264 5 M1 M1 NNP cord-018437-yjvwa1ot 264 6 ) ) -RRB- cord-018437-yjvwa1ot 264 7 is be VBZ cord-018437-yjvwa1ot 264 8 located locate VBN cord-018437-yjvwa1ot 264 9 just just RB cord-018437-yjvwa1ot 264 10 below below IN cord-018437-yjvwa1ot 264 11 the the DT cord-018437-yjvwa1ot 264 12 envelope envelope NN cord-018437-yjvwa1ot 264 13 . . . cord-018437-yjvwa1ot 265 1 The the DT cord-018437-yjvwa1ot 265 2 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 265 3 is be VBZ cord-018437-yjvwa1ot 265 4 composed compose VBN cord-018437-yjvwa1ot 265 5 of of IN cord-018437-yjvwa1ot 265 6 viral viral JJ cord-018437-yjvwa1ot 265 7 RNA RNA NNP cord-018437-yjvwa1ot 265 8 and and CC cord-018437-yjvwa1ot 265 9 nonstructural nonstructural JJ cord-018437-yjvwa1ot 265 10 proteins protein NNS cord-018437-yjvwa1ot 265 11 , , , cord-018437-yjvwa1ot 265 12 including include VBG cord-018437-yjvwa1ot 265 13 ribonucleoproteins ribonucleoprotein NNS cord-018437-yjvwa1ot 265 14 and and CC cord-018437-yjvwa1ot 265 15 polymerases polymerase NNS cord-018437-yjvwa1ot 265 16 . . . cord-018437-yjvwa1ot 266 1 The the DT cord-018437-yjvwa1ot 266 2 genome genome NN cord-018437-yjvwa1ot 266 3 of of IN cord-018437-yjvwa1ot 266 4 infl infl NN cord-018437-yjvwa1ot 266 5 uenza uenza NN cord-018437-yjvwa1ot 266 6 viruses virus NNS cord-018437-yjvwa1ot 266 7 is be VBZ cord-018437-yjvwa1ot 266 8 composed compose VBN cord-018437-yjvwa1ot 266 9 of of IN cord-018437-yjvwa1ot 266 10 negative negative JJ cord-018437-yjvwa1ot 266 11 - - HYPH cord-018437-yjvwa1ot 266 12 sense sense NN cord-018437-yjvwa1ot 266 13 ssRNA ssrna NN cord-018437-yjvwa1ot 266 14 . . . cord-018437-yjvwa1ot 267 1 All all DT cord-018437-yjvwa1ot 267 2 viral viral JJ cord-018437-yjvwa1ot 267 3 RNA RNA NNP cord-018437-yjvwa1ot 267 4 synthesis synthesis NN cord-018437-yjvwa1ot 267 5 occurs occur VBZ cord-018437-yjvwa1ot 267 6 in in IN cord-018437-yjvwa1ot 267 7 the the DT cord-018437-yjvwa1ot 267 8 nucleus nucleus NN cord-018437-yjvwa1ot 267 9 of of IN cord-018437-yjvwa1ot 267 10 the the DT cord-018437-yjvwa1ot 267 11 host host NN cord-018437-yjvwa1ot 267 12 cell cell NN cord-018437-yjvwa1ot 267 13 . . . cord-018437-yjvwa1ot 268 1 The the DT cord-018437-yjvwa1ot 268 2 A a NN cord-018437-yjvwa1ot 268 3 and and CC cord-018437-yjvwa1ot 268 4 B b NN cord-018437-yjvwa1ot 268 5 infl infl NN cord-018437-yjvwa1ot 268 6 uenza uenza NN cord-018437-yjvwa1ot 268 7 virus virus NN cord-018437-yjvwa1ot 268 8 genomes genome NNS cord-018437-yjvwa1ot 268 9 are be VBP cord-018437-yjvwa1ot 268 10 composed compose VBN cord-018437-yjvwa1ot 268 11 of of IN cord-018437-yjvwa1ot 268 12 eight eight CD cord-018437-yjvwa1ot 268 13 segments segment NNS cord-018437-yjvwa1ot 268 14 , , , cord-018437-yjvwa1ot 268 15 while while IN cord-018437-yjvwa1ot 268 16 the the DT cord-018437-yjvwa1ot 268 17 Infl Infl NNP cord-018437-yjvwa1ot 268 18 uenza uenza NNP cord-018437-yjvwa1ot 268 19 C C NNP cord-018437-yjvwa1ot 268 20 virus virus NN cord-018437-yjvwa1ot 268 21 genome genome NN cord-018437-yjvwa1ot 268 22 consists consist VBZ cord-018437-yjvwa1ot 268 23 of of IN cord-018437-yjvwa1ot 268 24 seven seven CD cord-018437-yjvwa1ot 268 25 segments segment NNS cord-018437-yjvwa1ot 268 26 ( ( -LRB- cord-018437-yjvwa1ot 268 27 Hayden Hayden NNP cord-018437-yjvwa1ot 268 28 and and CC cord-018437-yjvwa1ot 268 29 Palese Palese NNP cord-018437-yjvwa1ot 268 30 2009 2009 CD cord-018437-yjvwa1ot 268 31 ) ) -RRB- cord-018437-yjvwa1ot 268 32 . . . cord-018437-yjvwa1ot 269 1 The the DT cord-018437-yjvwa1ot 269 2 segments segment NNS cord-018437-yjvwa1ot 269 3 range range VBP cord-018437-yjvwa1ot 269 4 in in IN cord-018437-yjvwa1ot 269 5 size size NN cord-018437-yjvwa1ot 269 6 from from IN cord-018437-yjvwa1ot 269 7 ~900 ~900 JJ cord-018437-yjvwa1ot 269 8 to to IN cord-018437-yjvwa1ot 269 9 2,300 2,300 CD cord-018437-yjvwa1ot 269 10 nucleotides nucleotide NNS cord-018437-yjvwa1ot 269 11 in in IN cord-018437-yjvwa1ot 269 12 length length NN cord-018437-yjvwa1ot 269 13 . . . cord-018437-yjvwa1ot 270 1 Each each DT cord-018437-yjvwa1ot 270 2 segment segment NN cord-018437-yjvwa1ot 270 3 codes code VBZ cord-018437-yjvwa1ot 270 4 for for IN cord-018437-yjvwa1ot 270 5 one one CD cord-018437-yjvwa1ot 270 6 or or CC cord-018437-yjvwa1ot 270 7 more more JJR cord-018437-yjvwa1ot 270 8 viral viral JJ cord-018437-yjvwa1ot 270 9 proteins protein NNS cord-018437-yjvwa1ot 270 10 ( ( -LRB- cord-018437-yjvwa1ot 270 11 McCauley McCauley NNP cord-018437-yjvwa1ot 270 12 et et NNP cord-018437-yjvwa1ot 270 13 al al NNP cord-018437-yjvwa1ot 270 14 . . . cord-018437-yjvwa1ot 270 15 1983 1983 CD cord-018437-yjvwa1ot 270 16 ) ) -RRB- cord-018437-yjvwa1ot 270 17 . . . cord-018437-yjvwa1ot 271 1 The the DT cord-018437-yjvwa1ot 271 2 3′ 3′ CD cord-018437-yjvwa1ot 271 3 and and CC cord-018437-yjvwa1ot 271 4 5′ 5′ NN cord-018437-yjvwa1ot 271 5 ends end NNS cord-018437-yjvwa1ot 271 6 of of IN cord-018437-yjvwa1ot 271 7 each each DT cord-018437-yjvwa1ot 271 8 segment segment NN cord-018437-yjvwa1ot 271 9 contain contain VBP cord-018437-yjvwa1ot 271 10 noncoding noncoding JJ cord-018437-yjvwa1ot 271 11 , , , cord-018437-yjvwa1ot 271 12 regulatory regulatory JJ cord-018437-yjvwa1ot 271 13 regions region NNS cord-018437-yjvwa1ot 271 14 ( ( -LRB- cord-018437-yjvwa1ot 271 15 Fujii Fujii NNP cord-018437-yjvwa1ot 271 16 et et NNP cord-018437-yjvwa1ot 271 17 al al NNP cord-018437-yjvwa1ot 271 18 . . NNP cord-018437-yjvwa1ot 271 19 2005 2005 CD cord-018437-yjvwa1ot 271 20 ) ) -RRB- cord-018437-yjvwa1ot 271 21 . . . cord-018437-yjvwa1ot 272 1 The the DT cord-018437-yjvwa1ot 272 2 three three CD cord-018437-yjvwa1ot 272 3 largest large JJS cord-018437-yjvwa1ot 272 4 segments segment NNS cord-018437-yjvwa1ot 272 5 code code NN cord-018437-yjvwa1ot 272 6 for for IN cord-018437-yjvwa1ot 272 7 various various JJ cord-018437-yjvwa1ot 272 8 components component NNS cord-018437-yjvwa1ot 272 9 of of IN cord-018437-yjvwa1ot 272 10 RNA RNA NNP cord-018437-yjvwa1ot 272 11 polymerase polymerase NN cord-018437-yjvwa1ot 272 12 ; ; : cord-018437-yjvwa1ot 272 13 the the DT cord-018437-yjvwa1ot 272 14 PB1 pb1 JJ cord-018437-yjvwa1ot 272 15 segment segment NN cord-018437-yjvwa1ot 272 16 of of IN cord-018437-yjvwa1ot 272 17 Infl Infl NNP cord-018437-yjvwa1ot 272 18 uenza uenza NNP cord-018437-yjvwa1ot 273 1 A a DT cord-018437-yjvwa1ot 273 2 virus virus NN cord-018437-yjvwa1ot 273 3 has have VBZ cord-018437-yjvwa1ot 273 4 a a DT cord-018437-yjvwa1ot 273 5 second second JJ cord-018437-yjvwa1ot 273 6 open open JJ cord-018437-yjvwa1ot 273 7 reading reading NN cord-018437-yjvwa1ot 273 8 frame frame NN cord-018437-yjvwa1ot 273 9 that that WDT cord-018437-yjvwa1ot 273 10 encodes encode VBZ cord-018437-yjvwa1ot 273 11 the the DT cord-018437-yjvwa1ot 273 12 pro pro JJ cord-018437-yjvwa1ot 273 13 - - JJ cord-018437-yjvwa1ot 273 14 apoptotic apoptotic JJ cord-018437-yjvwa1ot 273 15 protein protein NN cord-018437-yjvwa1ot 273 16 PB1-F2 PB1-F2 NNP cord-018437-yjvwa1ot 273 17 . . . cord-018437-yjvwa1ot 274 1 In in IN cord-018437-yjvwa1ot 274 2 infl infl NN cord-018437-yjvwa1ot 274 3 uenza uenza NN cord-018437-yjvwa1ot 274 4 types type NNS cord-018437-yjvwa1ot 274 5 A A NNP cord-018437-yjvwa1ot 274 6 and and CC cord-018437-yjvwa1ot 274 7 B b NN cord-018437-yjvwa1ot 274 8 , , , cord-018437-yjvwa1ot 274 9 the the DT cord-018437-yjvwa1ot 274 10 fourth fourth JJ cord-018437-yjvwa1ot 274 11 and and CC cord-018437-yjvwa1ot 274 12 sixth sixth JJ cord-018437-yjvwa1ot 274 13 segments segment NNS cord-018437-yjvwa1ot 274 14 encode encode VB cord-018437-yjvwa1ot 274 15 for for IN cord-018437-yjvwa1ot 274 16 the the DT cord-018437-yjvwa1ot 274 17 surface surface NN cord-018437-yjvwa1ot 274 18 hemagglutinin hemagglutinin NN cord-018437-yjvwa1ot 274 19 ( ( -LRB- cord-018437-yjvwa1ot 274 20 HA HA NNP cord-018437-yjvwa1ot 274 21 ) ) -RRB- cord-018437-yjvwa1ot 274 22 and and CC cord-018437-yjvwa1ot 274 23 neuraminidase neuraminidase NN cord-018437-yjvwa1ot 274 24 ( ( -LRB- cord-018437-yjvwa1ot 274 25 NA NA NNP cord-018437-yjvwa1ot 274 26 ) ) -RRB- cord-018437-yjvwa1ot 274 27 glycoproteins glycoprotein NNS cord-018437-yjvwa1ot 274 28 , , , cord-018437-yjvwa1ot 274 29 respectively respectively RB cord-018437-yjvwa1ot 274 30 . . . cord-018437-yjvwa1ot 275 1 The the DT cord-018437-yjvwa1ot 275 2 Infl Infl NNP cord-018437-yjvwa1ot 275 3 uenza uenza NNP cord-018437-yjvwa1ot 275 4 A a DT cord-018437-yjvwa1ot 275 5 surface surface NN cord-018437-yjvwa1ot 275 6 protein protein NN cord-018437-yjvwa1ot 275 7 M2 M2 NNP cord-018437-yjvwa1ot 275 8 is be VBZ cord-018437-yjvwa1ot 275 9 encoded encode VBN cord-018437-yjvwa1ot 275 10 by by IN cord-018437-yjvwa1ot 275 11 the the DT cord-018437-yjvwa1ot 275 12 seventh seventh JJ cord-018437-yjvwa1ot 275 13 segment segment NN cord-018437-yjvwa1ot 275 14 ; ; : cord-018437-yjvwa1ot 275 15 Infl Infl NNP cord-018437-yjvwa1ot 275 16 uenza uenza NNP cord-018437-yjvwa1ot 275 17 B B NNP cord-018437-yjvwa1ot 275 18 surface surface NN cord-018437-yjvwa1ot 275 19 protein protein NN cord-018437-yjvwa1ot 275 20 NB NB NNP cord-018437-yjvwa1ot 275 21 is be VBZ cord-018437-yjvwa1ot 275 22 encoded encode VBN cord-018437-yjvwa1ot 275 23 by by IN cord-018437-yjvwa1ot 275 24 the the DT cord-018437-yjvwa1ot 275 25 sixth sixth JJ cord-018437-yjvwa1ot 275 26 segment segment NN cord-018437-yjvwa1ot 275 27 , , , cord-018437-yjvwa1ot 275 28 while while IN cord-018437-yjvwa1ot 275 29 the the DT cord-018437-yjvwa1ot 275 30 BM2 BM2 NNP cord-018437-yjvwa1ot 275 31 is be VBZ cord-018437-yjvwa1ot 275 32 encoded encode VBN cord-018437-yjvwa1ot 275 33 by by IN cord-018437-yjvwa1ot 275 34 the the DT cord-018437-yjvwa1ot 275 35 seventh seventh JJ cord-018437-yjvwa1ot 275 36 segment segment NN cord-018437-yjvwa1ot 275 37 . . . cord-018437-yjvwa1ot 276 1 The the DT cord-018437-yjvwa1ot 276 2 fi fi NN cord-018437-yjvwa1ot 276 3 fth fth NN cord-018437-yjvwa1ot 276 4 segment segment NN cord-018437-yjvwa1ot 276 5 of of IN cord-018437-yjvwa1ot 276 6 both both CC cord-018437-yjvwa1ot 276 7 A A NNP cord-018437-yjvwa1ot 276 8 and and CC cord-018437-yjvwa1ot 276 9 B b NN cord-018437-yjvwa1ot 276 10 infl infl NN cord-018437-yjvwa1ot 276 11 uenza uenza NN cord-018437-yjvwa1ot 276 12 viruses virus NNS cord-018437-yjvwa1ot 276 13 encodes encode VBZ cord-018437-yjvwa1ot 276 14 for for IN cord-018437-yjvwa1ot 276 15 the the DT cord-018437-yjvwa1ot 276 16 RNA RNA NNP cord-018437-yjvwa1ot 276 17 - - HYPH cord-018437-yjvwa1ot 276 18 binding bind VBG cord-018437-yjvwa1ot 276 19 nucleoprotein nucleoprotein NNP cord-018437-yjvwa1ot 276 20 ( ( -LRB- cord-018437-yjvwa1ot 276 21 NP NP NNP cord-018437-yjvwa1ot 276 22 ) ) -RRB- cord-018437-yjvwa1ot 276 23 . . . cord-018437-yjvwa1ot 277 1 The the DT cord-018437-yjvwa1ot 277 2 matrix matrix NN cord-018437-yjvwa1ot 277 3 protein protein NN cord-018437-yjvwa1ot 277 4 M1 M1 NNP cord-018437-yjvwa1ot 277 5 is be VBZ cord-018437-yjvwa1ot 277 6 encoded encode VBN cord-018437-yjvwa1ot 277 7 by by IN cord-018437-yjvwa1ot 277 8 the the DT cord-018437-yjvwa1ot 277 9 seventh seventh JJ cord-018437-yjvwa1ot 277 10 segment segment NN cord-018437-yjvwa1ot 277 11 of of IN cord-018437-yjvwa1ot 277 12 both both DT cord-018437-yjvwa1ot 277 13 viruses virus NNS cord-018437-yjvwa1ot 277 14 . . . cord-018437-yjvwa1ot 278 1 The the DT cord-018437-yjvwa1ot 278 2 eighth eighth JJ cord-018437-yjvwa1ot 278 3 and and CC cord-018437-yjvwa1ot 278 4 smallest small JJS cord-018437-yjvwa1ot 278 5 RNA RNA NNP cord-018437-yjvwa1ot 278 6 segment segment NN cord-018437-yjvwa1ot 278 7 of of IN cord-018437-yjvwa1ot 278 8 infl infl NNP cord-018437-yjvwa1ot 278 9 uenza uenza NNP cord-018437-yjvwa1ot 278 10 A A NNP cord-018437-yjvwa1ot 278 11 and and CC cord-018437-yjvwa1ot 278 12 B b NN cord-018437-yjvwa1ot 278 13 viruses virus NNS cord-018437-yjvwa1ot 278 14 encodes encode VBZ cord-018437-yjvwa1ot 278 15 for for IN cord-018437-yjvwa1ot 278 16 NS1 ns1 NN cord-018437-yjvwa1ot 278 17 , , , cord-018437-yjvwa1ot 278 18 a a DT cord-018437-yjvwa1ot 278 19 multifunctional multifunctional JJ cord-018437-yjvwa1ot 278 20 protein protein NN cord-018437-yjvwa1ot 278 21 with with IN cord-018437-yjvwa1ot 278 22 interferon interferon NN cord-018437-yjvwa1ot 278 23 antagonistic antagonistic JJ cord-018437-yjvwa1ot 278 24 properties property NNS cord-018437-yjvwa1ot 278 25 and and CC cord-018437-yjvwa1ot 278 26 NEP/ NEP/ NNP cord-018437-yjvwa1ot 278 27 NS2 NS2 NNP cord-018437-yjvwa1ot 278 28 protein protein NN cord-018437-yjvwa1ot 278 29 which which WDT cord-018437-yjvwa1ot 278 30 is be VBZ cord-018437-yjvwa1ot 278 31 involved involve VBN cord-018437-yjvwa1ot 278 32 in in IN cord-018437-yjvwa1ot 278 33 transport transport NN cord-018437-yjvwa1ot 278 34 of of IN cord-018437-yjvwa1ot 278 35 vRNPs vrnps RB cord-018437-yjvwa1ot 278 36 across across IN cord-018437-yjvwa1ot 278 37 the the DT cord-018437-yjvwa1ot 278 38 nuclear nuclear JJ cord-018437-yjvwa1ot 278 39 membrane membrane NN cord-018437-yjvwa1ot 278 40 of of IN cord-018437-yjvwa1ot 278 41 the the DT cord-018437-yjvwa1ot 278 42 host host NN cord-018437-yjvwa1ot 278 43 cell cell NN cord-018437-yjvwa1ot 278 44 . . . cord-018437-yjvwa1ot 279 1 The the DT cord-018437-yjvwa1ot 279 2 Names Names NNPS cord-018437-yjvwa1ot 279 3 of of IN cord-018437-yjvwa1ot 279 4 clinical clinical JJ cord-018437-yjvwa1ot 279 5 isolates isolate NNS cord-018437-yjvwa1ot 279 6 of of IN cord-018437-yjvwa1ot 279 7 human human JJ cord-018437-yjvwa1ot 279 8 infl infl NN cord-018437-yjvwa1ot 279 9 uenza uenza NNP cord-018437-yjvwa1ot 279 10 isolates isolate NNS cord-018437-yjvwa1ot 279 11 include include VBP cord-018437-yjvwa1ot 279 12 the the DT cord-018437-yjvwa1ot 279 13 species specie NNS cord-018437-yjvwa1ot 279 14 of of IN cord-018437-yjvwa1ot 279 15 origin origin NN cord-018437-yjvwa1ot 279 16 , , , cord-018437-yjvwa1ot 279 17 isolation isolation NN cord-018437-yjvwa1ot 279 18 location location NN cord-018437-yjvwa1ot 279 19 , , , cord-018437-yjvwa1ot 279 20 number number NN cord-018437-yjvwa1ot 279 21 of of IN cord-018437-yjvwa1ot 279 22 the the DT cord-018437-yjvwa1ot 279 23 isolate isolate NN cord-018437-yjvwa1ot 279 24 , , , cord-018437-yjvwa1ot 279 25 and and CC cord-018437-yjvwa1ot 279 26 year year NN cord-018437-yjvwa1ot 279 27 of of IN cord-018437-yjvwa1ot 279 28 isolation isolation NN cord-018437-yjvwa1ot 279 29 ; ; : cord-018437-yjvwa1ot 279 30 Infl Infl NNP cord-018437-yjvwa1ot 279 31 uenza uenza NNP cord-018437-yjvwa1ot 279 32 A a DT cord-018437-yjvwa1ot 279 33 virus virus NN cord-018437-yjvwa1ot 279 34 isolates isolate VBZ cord-018437-yjvwa1ot 279 35 also also RB cord-018437-yjvwa1ot 279 36 include include VBP cord-018437-yjvwa1ot 279 37 the the DT cord-018437-yjvwa1ot 279 38 hemagglutinin hemagglutinin NN cord-018437-yjvwa1ot 279 39 ( ( -LRB- cord-018437-yjvwa1ot 279 40 H1 h1 NN cord-018437-yjvwa1ot 279 41 to to IN cord-018437-yjvwa1ot 279 42 H16 H16 NNP cord-018437-yjvwa1ot 279 43 ) ) -RRB- cord-018437-yjvwa1ot 279 44 and and CC cord-018437-yjvwa1ot 279 45 neuraminidase neuraminidase NN cord-018437-yjvwa1ot 279 46 ( ( -LRB- cord-018437-yjvwa1ot 279 47 N1 n1 NN cord-018437-yjvwa1ot 279 48 to to IN cord-018437-yjvwa1ot 279 49 N9 N9 NNP cord-018437-yjvwa1ot 279 50 ) ) -RRB- cord-018437-yjvwa1ot 279 51 subtypes subtype NNS cord-018437-yjvwa1ot 279 52 ( ( -LRB- cord-018437-yjvwa1ot 279 53 Atmar Atmar NNP cord-018437-yjvwa1ot 279 54 and and CC cord-018437-yjvwa1ot 279 55 Lindstrom Lindstrom NNP cord-018437-yjvwa1ot 279 56 2012 2012 CD cord-018437-yjvwa1ot 279 57 ) ) -RRB- cord-018437-yjvwa1ot 279 58 . . . cord-018437-yjvwa1ot 280 1 For for IN cord-018437-yjvwa1ot 280 2 example example NN cord-018437-yjvwa1ot 280 3 , , , cord-018437-yjvwa1ot 280 4 A a NN cord-018437-yjvwa1ot 280 5 / / SYM cord-018437-yjvwa1ot 280 6 California/7/2009 california/7/2009 NN cord-018437-yjvwa1ot 280 7 ( ( -LRB- cord-018437-yjvwa1ot 280 8 H1N1 H1N1 NNP cord-018437-yjvwa1ot 280 9 ) ) -RRB- cord-018437-yjvwa1ot 280 10 , , , cord-018437-yjvwa1ot 280 11 A a NN cord-018437-yjvwa1ot 280 12 / / SYM cord-018437-yjvwa1ot 280 13 Victoria/361/2011 victoria/361/2011 NN cord-018437-yjvwa1ot 280 14 ( ( -LRB- cord-018437-yjvwa1ot 280 15 H3N2 H3N2 NNP cord-018437-yjvwa1ot 280 16 ) ) -RRB- cord-018437-yjvwa1ot 280 17 , , , cord-018437-yjvwa1ot 280 18 and and CC cord-018437-yjvwa1ot 280 19 B/ B/ NNP cord-018437-yjvwa1ot 280 20 Wisconsin/1/2010 wisconsin/1/2010 NN cord-018437-yjvwa1ot 280 21 viruses virus NNS cord-018437-yjvwa1ot 280 22 were be VBD cord-018437-yjvwa1ot 280 23 recommended recommend VBN cord-018437-yjvwa1ot 280 24 for for IN cord-018437-yjvwa1ot 280 25 the the DT cord-018437-yjvwa1ot 280 26 2012 2012 CD cord-018437-yjvwa1ot 280 27 - - SYM cord-018437-yjvwa1ot 280 28 2013 2013 CD cord-018437-yjvwa1ot 280 29 seasonal seasonal JJ cord-018437-yjvwa1ot 280 30 infl infl NN cord-018437-yjvwa1ot 280 31 uenza uenza NNP cord-018437-yjvwa1ot 280 32 vaccine vaccine NN cord-018437-yjvwa1ot 280 33 . . . cord-018437-yjvwa1ot 281 1 Large large JJ cord-018437-yjvwa1ot 281 2 outbreaks outbreak NNS cord-018437-yjvwa1ot 281 3 have have VBP cord-018437-yjvwa1ot 281 4 only only RB cord-018437-yjvwa1ot 281 5 occurred occur VBN cord-018437-yjvwa1ot 281 6 with with IN cord-018437-yjvwa1ot 281 7 H1 H1 NNP cord-018437-yjvwa1ot 281 8 , , , cord-018437-yjvwa1ot 281 9 H2 H2 NNP cord-018437-yjvwa1ot 281 10 , , , cord-018437-yjvwa1ot 281 11 and and CC cord-018437-yjvwa1ot 281 12 H3 H3 NNP cord-018437-yjvwa1ot 281 13 and and CC cord-018437-yjvwa1ot 281 14 neuraminidases neuraminidases NNP cord-018437-yjvwa1ot 281 15 N1 N1 NNP cord-018437-yjvwa1ot 281 16 and and CC cord-018437-yjvwa1ot 281 17 N2 N2 NNP cord-018437-yjvwa1ot 281 18 viral viral JJ cord-018437-yjvwa1ot 281 19 subtypes subtype NNS cord-018437-yjvwa1ot 281 20 . . . cord-018437-yjvwa1ot 282 1 Antigenic antigenic JJ cord-018437-yjvwa1ot 282 2 drift drift NN cord-018437-yjvwa1ot 282 3 and and CC cord-018437-yjvwa1ot 282 4 antigenic antigenic JJ cord-018437-yjvwa1ot 282 5 shift shift NN cord-018437-yjvwa1ot 282 6 contribute contribute VBP cord-018437-yjvwa1ot 282 7 to to IN cord-018437-yjvwa1ot 282 8 reinfection reinfection NN cord-018437-yjvwa1ot 282 9 with with IN cord-018437-yjvwa1ot 282 10 infl infl NN cord-018437-yjvwa1ot 282 11 uenza uenza NN cord-018437-yjvwa1ot 282 12 viruses virus NNS cord-018437-yjvwa1ot 282 13 ( ( -LRB- cord-018437-yjvwa1ot 282 14 Taubenberger Taubenberger NNP cord-018437-yjvwa1ot 282 15 and and CC cord-018437-yjvwa1ot 282 16 Kash Kash NNP cord-018437-yjvwa1ot 282 17 2010 2010 CD cord-018437-yjvwa1ot 282 18 ) ) -RRB- cord-018437-yjvwa1ot 282 19 . . . cord-018437-yjvwa1ot 283 1 Antigenic antigenic JJ cord-018437-yjvwa1ot 283 2 drift drift NN cord-018437-yjvwa1ot 283 3 is be VBZ cord-018437-yjvwa1ot 283 4 caused cause VBN cord-018437-yjvwa1ot 283 5 by by IN cord-018437-yjvwa1ot 283 6 a a DT cord-018437-yjvwa1ot 283 7 gradual gradual JJ cord-018437-yjvwa1ot 283 8 accumulation accumulation NN cord-018437-yjvwa1ot 283 9 of of IN cord-018437-yjvwa1ot 283 10 point point NN cord-018437-yjvwa1ot 283 11 mutations mutation NNS cord-018437-yjvwa1ot 283 12 in in IN cord-018437-yjvwa1ot 283 13 hemagglutinin hemagglutinin NN cord-018437-yjvwa1ot 283 14 and and CC cord-018437-yjvwa1ot 283 15 neuraminidase neuraminidase NN cord-018437-yjvwa1ot 283 16 genes gene NNS cord-018437-yjvwa1ot 283 17 , , , cord-018437-yjvwa1ot 283 18 which which WDT cord-018437-yjvwa1ot 283 19 result result VBP cord-018437-yjvwa1ot 283 20 in in IN cord-018437-yjvwa1ot 283 21 minor minor JJ cord-018437-yjvwa1ot 283 22 antigenic antigenic JJ cord-018437-yjvwa1ot 283 23 changes change NNS cord-018437-yjvwa1ot 283 24 in in IN cord-018437-yjvwa1ot 283 25 these these DT cord-018437-yjvwa1ot 283 26 proteins protein NNS cord-018437-yjvwa1ot 283 27 . . . cord-018437-yjvwa1ot 284 1 Antigenic antigenic JJ cord-018437-yjvwa1ot 284 2 shift shift NN cord-018437-yjvwa1ot 284 3 is be VBZ cord-018437-yjvwa1ot 284 4 caused cause VBN cord-018437-yjvwa1ot 284 5 by by IN cord-018437-yjvwa1ot 284 6 a a DT cord-018437-yjvwa1ot 284 7 virus virus NN cord-018437-yjvwa1ot 284 8 created create VBN cord-018437-yjvwa1ot 284 9 by by IN cord-018437-yjvwa1ot 284 10 reassortment reassortment NN cord-018437-yjvwa1ot 284 11 of of IN cord-018437-yjvwa1ot 284 12 infl infl NNP cord-018437-yjvwa1ot 284 13 uenza uenza NNP cord-018437-yjvwa1ot 284 14 virus virus NN cord-018437-yjvwa1ot 284 15 RNA RNA NNP cord-018437-yjvwa1ot 284 16 segments segment NNS cord-018437-yjvwa1ot 284 17 during during IN cord-018437-yjvwa1ot 284 18 coinfection coinfection NN cord-018437-yjvwa1ot 284 19 of of IN cord-018437-yjvwa1ot 284 20 a a DT cord-018437-yjvwa1ot 284 21 host host NN cord-018437-yjvwa1ot 284 22 , , , cord-018437-yjvwa1ot 284 23 usually usually RB cord-018437-yjvwa1ot 284 24 with with IN cord-018437-yjvwa1ot 284 25 a a DT cord-018437-yjvwa1ot 284 26 human human JJ cord-018437-yjvwa1ot 284 27 infl infl NN cord-018437-yjvwa1ot 284 28 uenza uenza NNP cord-018437-yjvwa1ot 284 29 virus virus NN cord-018437-yjvwa1ot 284 30 and and CC cord-018437-yjvwa1ot 284 31 an an DT cord-018437-yjvwa1ot 284 32 avian avian JJ cord-018437-yjvwa1ot 284 33 or or CC cord-018437-yjvwa1ot 284 34 swine swine NN cord-018437-yjvwa1ot 284 35 infl infl NNP cord-018437-yjvwa1ot 284 36 uenza uenza NNP cord-018437-yjvwa1ot 284 37 virus virus NN cord-018437-yjvwa1ot 284 38 or or CC cord-018437-yjvwa1ot 284 39 through through IN cord-018437-yjvwa1ot 284 40 introduction introduction NN cord-018437-yjvwa1ot 284 41 of of IN cord-018437-yjvwa1ot 284 42 a a DT cord-018437-yjvwa1ot 284 43 nonhuman nonhuman NN cord-018437-yjvwa1ot 284 44 infl infl XX cord-018437-yjvwa1ot 284 45 uenza uenza NNP cord-018437-yjvwa1ot 284 46 virus virus NN cord-018437-yjvwa1ot 284 47 strain strain NN cord-018437-yjvwa1ot 284 48 into into IN cord-018437-yjvwa1ot 284 49 human human JJ cord-018437-yjvwa1ot 284 50 populations population NNS cord-018437-yjvwa1ot 284 51 after after IN cord-018437-yjvwa1ot 284 52 mutation mutation NN cord-018437-yjvwa1ot 284 53 during during IN cord-018437-yjvwa1ot 284 54 a a DT cord-018437-yjvwa1ot 284 55 host host NN cord-018437-yjvwa1ot 284 56 - - HYPH cord-018437-yjvwa1ot 284 57 species species NN cord-018437-yjvwa1ot 284 58 infection infection NN cord-018437-yjvwa1ot 284 59 creates create VBZ cord-018437-yjvwa1ot 284 60 a a DT cord-018437-yjvwa1ot 284 61 new new JJ cord-018437-yjvwa1ot 284 62 isolate isolate NN cord-018437-yjvwa1ot 284 63 permissive permissive JJ cord-018437-yjvwa1ot 284 64 for for IN cord-018437-yjvwa1ot 284 65 interspecies interspecie NNS cord-018437-yjvwa1ot 284 66 transmission transmission NN cord-018437-yjvwa1ot 284 67 . . . cord-018437-yjvwa1ot 285 1 Papillomaviridae papillomaviridae NN cord-018437-yjvwa1ot 285 2 : : : cord-018437-yjvwa1ot 286 1 The the DT cord-018437-yjvwa1ot 286 2 papillomaviruses papillomaviruse NNS cord-018437-yjvwa1ot 286 3 ( ( -LRB- cord-018437-yjvwa1ot 286 4 PVs pv NNS cord-018437-yjvwa1ot 286 5 ) ) -RRB- cord-018437-yjvwa1ot 286 6 represent represent VBP cord-018437-yjvwa1ot 286 7 a a DT cord-018437-yjvwa1ot 286 8 large large JJ cord-018437-yjvwa1ot 286 9 ( ( -LRB- cord-018437-yjvwa1ot 286 10 and and CC cord-018437-yjvwa1ot 286 11 growing grow VBG cord-018437-yjvwa1ot 286 12 ) ) -RRB- cord-018437-yjvwa1ot 286 13 family family NN cord-018437-yjvwa1ot 286 14 of of IN cord-018437-yjvwa1ot 286 15 viruses virus NNS cord-018437-yjvwa1ot 286 16 that that WDT cord-018437-yjvwa1ot 286 17 currently currently RB cord-018437-yjvwa1ot 286 18 includes include VBZ cord-018437-yjvwa1ot 286 19 30 30 CD cord-018437-yjvwa1ot 286 20 different different JJ cord-018437-yjvwa1ot 286 21 genera genus NNS cord-018437-yjvwa1ot 286 22 and and CC cord-018437-yjvwa1ot 286 23 69 69 CD cord-018437-yjvwa1ot 286 24 species specie NNS cord-018437-yjvwa1ot 286 25 ; ; : cord-018437-yjvwa1ot 286 26 the the DT cord-018437-yjvwa1ot 286 27 taxonomy taxonomy NN cord-018437-yjvwa1ot 286 28 has have VBZ cord-018437-yjvwa1ot 286 29 undergone undergo VBN cord-018437-yjvwa1ot 286 30 signifi signifi NNP cord-018437-yjvwa1ot 286 31 ca can MD cord-018437-yjvwa1ot 286 32 nt not RB cord-018437-yjvwa1ot 286 33 reorganization reorganization NN cord-018437-yjvwa1ot 286 34 in in IN cord-018437-yjvwa1ot 286 35 recent recent JJ cord-018437-yjvwa1ot 286 36 years year NNS cord-018437-yjvwa1ot 287 1 ( ( -LRB- cord-018437-yjvwa1ot 287 2 Bravo Bravo NNP cord-018437-yjvwa1ot 287 3 et et FW cord-018437-yjvwa1ot 287 4 al al NNP cord-018437-yjvwa1ot 287 5 . . NNP cord-018437-yjvwa1ot 287 6 2010 2010 CD cord-018437-yjvwa1ot 287 7 ) ) -RRB- cord-018437-yjvwa1ot 287 8 . . . cord-018437-yjvwa1ot 288 1 The the DT cord-018437-yjvwa1ot 288 2 oncogenic oncogenic JJ cord-018437-yjvwa1ot 288 3 potential potential NN cord-018437-yjvwa1ot 288 4 of of IN cord-018437-yjvwa1ot 288 5 human human JJ cord-018437-yjvwa1ot 288 6 papillomaviruses papillomaviruse NNS cord-018437-yjvwa1ot 288 7 is be VBZ cord-018437-yjvwa1ot 288 8 well well RB cord-018437-yjvwa1ot 288 9 established establish VBN cord-018437-yjvwa1ot 288 10 . . . cord-018437-yjvwa1ot 289 1 PVs pv NNS cord-018437-yjvwa1ot 289 2 are be VBP cord-018437-yjvwa1ot 289 3 non non JJ cord-018437-yjvwa1ot 289 4 - - JJ cord-018437-yjvwa1ot 289 5 enveloped enveloped JJ cord-018437-yjvwa1ot 289 6 ; ; : cord-018437-yjvwa1ot 289 7 virions virion NNS cord-018437-yjvwa1ot 289 8 are be VBP cord-018437-yjvwa1ot 289 9 icosahedral icosahedral JJ cord-018437-yjvwa1ot 289 10 with with IN cord-018437-yjvwa1ot 289 11 diameters diameter NNS cord-018437-yjvwa1ot 289 12 of of IN cord-018437-yjvwa1ot 289 13 50 50 CD cord-018437-yjvwa1ot 289 14 - - SYM cord-018437-yjvwa1ot 289 15 55 55 CD cord-018437-yjvwa1ot 289 16 nm nm NN cord-018437-yjvwa1ot 289 17 . . . cord-018437-yjvwa1ot 290 1 The the DT cord-018437-yjvwa1ot 290 2 capsid capsid NN cord-018437-yjvwa1ot 290 3 contains contain VBZ cord-018437-yjvwa1ot 290 4 two two CD cord-018437-yjvwa1ot 290 5 structural structural JJ cord-018437-yjvwa1ot 290 6 proteins protein NNS cord-018437-yjvwa1ot 290 7 , , , cord-018437-yjvwa1ot 290 8 L1 L1 NNP cord-018437-yjvwa1ot 290 9 , , , cord-018437-yjvwa1ot 290 10 the the DT cord-018437-yjvwa1ot 290 11 most most RBS cord-018437-yjvwa1ot 290 12 abundant abundant JJ cord-018437-yjvwa1ot 290 13 viral viral JJ cord-018437-yjvwa1ot 290 14 protein protein NN cord-018437-yjvwa1ot 290 15 , , , cord-018437-yjvwa1ot 290 16 and and CC cord-018437-yjvwa1ot 290 17 L2 L2 NNP cord-018437-yjvwa1ot 290 18 . . . cord-018437-yjvwa1ot 291 1 The the DT cord-018437-yjvwa1ot 291 2 PV PV NNP cord-018437-yjvwa1ot 291 3 genome genome NN cord-018437-yjvwa1ot 291 4 consists consist VBZ cord-018437-yjvwa1ot 291 5 of of IN cord-018437-yjvwa1ot 291 6 a a DT cord-018437-yjvwa1ot 291 7 single single JJ cord-018437-yjvwa1ot 291 8 molecule molecule NN cord-018437-yjvwa1ot 291 9 of of IN cord-018437-yjvwa1ot 291 10 circularized circularize VBN cord-018437-yjvwa1ot 291 11 dsDNA dsdna RB cord-018437-yjvwa1ot 292 1 ( ( -LRB- cord-018437-yjvwa1ot 292 2 Zheng Zheng NNP cord-018437-yjvwa1ot 292 3 and and CC cord-018437-yjvwa1ot 292 4 Baker Baker NNP cord-018437-yjvwa1ot 292 5 2006 2006 CD cord-018437-yjvwa1ot 292 6 ) ) -RRB- cord-018437-yjvwa1ot 292 7 . . . cord-018437-yjvwa1ot 293 1 The the DT cord-018437-yjvwa1ot 293 2 open open JJ cord-018437-yjvwa1ot 293 3 reading reading NN cord-018437-yjvwa1ot 293 4 frames frame NNS cord-018437-yjvwa1ot 293 5 for for IN cord-018437-yjvwa1ot 293 6 all all DT cord-018437-yjvwa1ot 293 7 viral viral JJ cord-018437-yjvwa1ot 293 8 genes gene NNS cord-018437-yjvwa1ot 293 9 are be VBP cord-018437-yjvwa1ot 293 10 located locate VBN cord-018437-yjvwa1ot 293 11 on on IN cord-018437-yjvwa1ot 293 12 only only RB cord-018437-yjvwa1ot 293 13 one one CD cord-018437-yjvwa1ot 293 14 of of IN cord-018437-yjvwa1ot 293 15 the the DT cord-018437-yjvwa1ot 293 16 DNA dna NN cord-018437-yjvwa1ot 293 17 strands strand NNS cord-018437-yjvwa1ot 293 18 , , , cord-018437-yjvwa1ot 293 19 and and CC cord-018437-yjvwa1ot 293 20 transcription transcription NN cord-018437-yjvwa1ot 293 21 proceeds proceed NNS cord-018437-yjvwa1ot 293 22 in in IN cord-018437-yjvwa1ot 293 23 a a DT cord-018437-yjvwa1ot 293 24 single single JJ cord-018437-yjvwa1ot 293 25 direction direction NN cord-018437-yjvwa1ot 293 26 . . . cord-018437-yjvwa1ot 294 1 There there EX cord-018437-yjvwa1ot 294 2 are be VBP cord-018437-yjvwa1ot 294 3 eight eight CD cord-018437-yjvwa1ot 294 4 early early JJ cord-018437-yjvwa1ot 294 5 ( ( -LRB- cord-018437-yjvwa1ot 294 6 E e NN cord-018437-yjvwa1ot 294 7 ) ) -RRB- cord-018437-yjvwa1ot 294 8 open open JJ cord-018437-yjvwa1ot 294 9 reading reading NN cord-018437-yjvwa1ot 294 10 frames frame NNS cord-018437-yjvwa1ot 294 11 that that WDT cord-018437-yjvwa1ot 294 12 encode encode VBP cord-018437-yjvwa1ot 294 13 for for IN cord-018437-yjvwa1ot 294 14 regulatory regulatory JJ cord-018437-yjvwa1ot 294 15 proteins protein NNS cord-018437-yjvwa1ot 294 16 that that WDT cord-018437-yjvwa1ot 294 17 control control VBP cord-018437-yjvwa1ot 294 18 viral viral JJ cord-018437-yjvwa1ot 294 19 metabolism metabolism NN cord-018437-yjvwa1ot 294 20 and and CC cord-018437-yjvwa1ot 294 21 DNA dna NN cord-018437-yjvwa1ot 294 22 synthesis synthesis NN cord-018437-yjvwa1ot 294 23 . . . cord-018437-yjvwa1ot 295 1 The the DT cord-018437-yjvwa1ot 295 2 E6 e6 NN cord-018437-yjvwa1ot 295 3 proteins protein NNS cord-018437-yjvwa1ot 295 4 of of IN cord-018437-yjvwa1ot 295 5 high high JJ cord-018437-yjvwa1ot 295 6 - - HYPH cord-018437-yjvwa1ot 295 7 risk risk NN cord-018437-yjvwa1ot 295 8 HPV hpv NN cord-018437-yjvwa1ot 295 9 types type NNS cord-018437-yjvwa1ot 295 10 have have VBP cord-018437-yjvwa1ot 295 11 anti anti JJ cord-018437-yjvwa1ot 295 12 - - JJ cord-018437-yjvwa1ot 295 13 apoptotic apoptotic JJ cord-018437-yjvwa1ot 295 14 effects effect NNS cord-018437-yjvwa1ot 295 15 and and CC cord-018437-yjvwa1ot 295 16 interfere interfere VB cord-018437-yjvwa1ot 295 17 with with IN cord-018437-yjvwa1ot 295 18 p53 p53 NN cord-018437-yjvwa1ot 295 19 regulatory regulatory JJ cord-018437-yjvwa1ot 295 20 function function NN cord-018437-yjvwa1ot 295 21 in in IN cord-018437-yjvwa1ot 295 22 infected infected JJ cord-018437-yjvwa1ot 295 23 host host NN cord-018437-yjvwa1ot 295 24 cells cell NNS cord-018437-yjvwa1ot 295 25 ( ( -LRB- cord-018437-yjvwa1ot 295 26 Howley Howley NNP cord-018437-yjvwa1ot 295 27 et et NNP cord-018437-yjvwa1ot 295 28 al al NNP cord-018437-yjvwa1ot 295 29 . . NNP cord-018437-yjvwa1ot 295 30 1990 1990 CD cord-018437-yjvwa1ot 295 31 ) ) -RRB- cord-018437-yjvwa1ot 295 32 . . . cord-018437-yjvwa1ot 296 1 Two two CD cord-018437-yjvwa1ot 296 2 late late JJ cord-018437-yjvwa1ot 296 3 ( ( -LRB- cord-018437-yjvwa1ot 296 4 L l NN cord-018437-yjvwa1ot 296 5 ) ) -RRB- cord-018437-yjvwa1ot 296 6 reading read VBG cord-018437-yjvwa1ot 296 7 frames frame NNS cord-018437-yjvwa1ot 296 8 encode encode VBP cord-018437-yjvwa1ot 296 9 for for IN cord-018437-yjvwa1ot 296 10 synthesis synthesis NN cord-018437-yjvwa1ot 296 11 of of IN cord-018437-yjvwa1ot 296 12 the the DT cord-018437-yjvwa1ot 296 13 structural structural JJ cord-018437-yjvwa1ot 296 14 proteins protein NNS cord-018437-yjvwa1ot 296 15 L1 L1 NNP cord-018437-yjvwa1ot 296 16 and and CC cord-018437-yjvwa1ot 296 17 L2 L2 NNP cord-018437-yjvwa1ot 296 18 . . . cord-018437-yjvwa1ot 297 1 Epithelial epithelial JJ cord-018437-yjvwa1ot 297 2 cells cell NNS cord-018437-yjvwa1ot 297 3 of of IN cord-018437-yjvwa1ot 297 4 a a DT cord-018437-yjvwa1ot 297 5 wide wide JJ cord-018437-yjvwa1ot 297 6 variety variety NN cord-018437-yjvwa1ot 297 7 of of IN cord-018437-yjvwa1ot 297 8 vertebrate vertebrate JJ cord-018437-yjvwa1ot 297 9 hosts host NNS cord-018437-yjvwa1ot 297 10 are be VBP cord-018437-yjvwa1ot 297 11 susceptible susceptible JJ cord-018437-yjvwa1ot 297 12 to to IN cord-018437-yjvwa1ot 297 13 papillomavirus papillomavirus NN cord-018437-yjvwa1ot 297 14 infection infection NN cord-018437-yjvwa1ot 297 15 , , , cord-018437-yjvwa1ot 297 16 but but CC cord-018437-yjvwa1ot 297 17 the the DT cord-018437-yjvwa1ot 297 18 different different JJ cord-018437-yjvwa1ot 297 19 host host NN cord-018437-yjvwa1ot 297 20 species specie NNS cord-018437-yjvwa1ot 297 21 are be VBP cord-018437-yjvwa1ot 297 22 only only RB cord-018437-yjvwa1ot 297 23 susceptible susceptible JJ cord-018437-yjvwa1ot 297 24 to to IN cord-018437-yjvwa1ot 297 25 species species NN cord-018437-yjvwa1ot 297 26 - - HYPH cord-018437-yjvwa1ot 297 27 specifi specifi NN cord-018437-yjvwa1ot 297 28 c c NN cord-018437-yjvwa1ot 297 29 viruses virus NNS cord-018437-yjvwa1ot 297 30 . . . cord-018437-yjvwa1ot 298 1 Papillomaviruses papillomaviruse NNS cord-018437-yjvwa1ot 298 2 have have VBP cord-018437-yjvwa1ot 298 3 been be VBN cord-018437-yjvwa1ot 298 4 classifi classifi NNP cord-018437-yjvwa1ot 298 5 ed ed NN cord-018437-yjvwa1ot 298 6 according accord VBG cord-018437-yjvwa1ot 298 7 to to IN cord-018437-yjvwa1ot 298 8 susceptible susceptible JJ cord-018437-yjvwa1ot 298 9 host host NN cord-018437-yjvwa1ot 298 10 species specie NNS cord-018437-yjvwa1ot 298 11 and and CC cord-018437-yjvwa1ot 298 12 the the DT cord-018437-yjvwa1ot 298 13 type type NN cord-018437-yjvwa1ot 298 14 of of IN cord-018437-yjvwa1ot 298 15 disease disease NN cord-018437-yjvwa1ot 298 16 produced produce VBN cord-018437-yjvwa1ot 298 17 , , , cord-018437-yjvwa1ot 298 18 but but CC cord-018437-yjvwa1ot 298 19 comparison comparison NN cord-018437-yjvwa1ot 298 20 of of IN cord-018437-yjvwa1ot 298 21 sequence sequence NN cord-018437-yjvwa1ot 298 22 differences difference NNS cord-018437-yjvwa1ot 298 23 of of IN cord-018437-yjvwa1ot 298 24 the the DT cord-018437-yjvwa1ot 298 25 L1 L1 NNP cord-018437-yjvwa1ot 298 26 reading reading NN cord-018437-yjvwa1ot 298 27 frame frame NN cord-018437-yjvwa1ot 298 28 has have VBZ cord-018437-yjvwa1ot 298 29 provided provide VBN cord-018437-yjvwa1ot 298 30 a a DT cord-018437-yjvwa1ot 298 31 more more RBR cord-018437-yjvwa1ot 298 32 detailed detailed JJ cord-018437-yjvwa1ot 298 33 description description NN cord-018437-yjvwa1ot 298 34 of of IN cord-018437-yjvwa1ot 298 35 papillomavirus papillomavirus NN cord-018437-yjvwa1ot 298 36 phylogeny phylogeny NN cord-018437-yjvwa1ot 298 37 ( ( -LRB- cord-018437-yjvwa1ot 298 38 de de FW cord-018437-yjvwa1ot 298 39 Villiers Villiers NNP cord-018437-yjvwa1ot 298 40 et et NNP cord-018437-yjvwa1ot 298 41 al al NNP cord-018437-yjvwa1ot 298 42 . . . cord-018437-yjvwa1ot 298 43 2004 2004 CD cord-018437-yjvwa1ot 298 44 ) ) -RRB- cord-018437-yjvwa1ot 298 45 . . . cord-018437-yjvwa1ot 299 1 The the DT cord-018437-yjvwa1ot 299 2 family family NN cord-018437-yjvwa1ot 299 3 Papillomaviridae Papillomaviridae NNP cord-018437-yjvwa1ot 299 4 is be VBZ cord-018437-yjvwa1ot 299 5 not not RB cord-018437-yjvwa1ot 299 6 assigned assign VBN cord-018437-yjvwa1ot 299 7 to to IN cord-018437-yjvwa1ot 299 8 an an DT cord-018437-yjvwa1ot 299 9 order order NN cord-018437-yjvwa1ot 299 10 . . . cord-018437-yjvwa1ot 300 1 Human human JJ cord-018437-yjvwa1ot 300 2 pathogens pathogen NNS cord-018437-yjvwa1ot 300 3 are be VBP cord-018437-yjvwa1ot 300 4 clustered cluster VBN cord-018437-yjvwa1ot 300 5 within within IN cord-018437-yjvwa1ot 300 6 fi fi NNP cord-018437-yjvwa1ot 300 7 ve ve VBD cord-018437-yjvwa1ot 300 8 papillomavirus papillomavirus NN cord-018437-yjvwa1ot 300 9 genera genus NNS cord-018437-yjvwa1ot 300 10 . . . cord-018437-yjvwa1ot 301 1 Paramyxoviridae Paramyxoviridae NNP cord-018437-yjvwa1ot 301 2 : : : cord-018437-yjvwa1ot 302 1 The the DT cord-018437-yjvwa1ot 302 2 Paramyxoviruses Paramyxoviruses NNPS cord-018437-yjvwa1ot 302 3 are be VBP cord-018437-yjvwa1ot 302 4 enveloped envelop VBN cord-018437-yjvwa1ot 302 5 ( ( -LRB- cord-018437-yjvwa1ot 302 6 host host NN cord-018437-yjvwa1ot 302 7 cytoplasmic cytoplasmic JJ cord-018437-yjvwa1ot 302 8 membrane membrane NN cord-018437-yjvwa1ot 302 9 ) ) -RRB- cord-018437-yjvwa1ot 302 10 with with IN cord-018437-yjvwa1ot 302 11 an an DT cord-018437-yjvwa1ot 302 12 unsegmented unsegmented JJ cord-018437-yjvwa1ot 302 13 negative negative JJ cord-018437-yjvwa1ot 302 14 - - HYPH cord-018437-yjvwa1ot 302 15 sense sense NN cord-018437-yjvwa1ot 302 16 ssRNA ssrna NN cord-018437-yjvwa1ot 302 17 genome genome NN cord-018437-yjvwa1ot 302 18 ( ( -LRB- cord-018437-yjvwa1ot 302 19 15 15 CD cord-018437-yjvwa1ot 302 20 - - SYM cord-018437-yjvwa1ot 302 21 19 19 CD cord-018437-yjvwa1ot 302 22 kb kb NNP cord-018437-yjvwa1ot 302 23 ) ) -RRB- cord-018437-yjvwa1ot 302 24 . . . cord-018437-yjvwa1ot 303 1 The the DT cord-018437-yjvwa1ot 303 2 viral viral JJ cord-018437-yjvwa1ot 303 3 RNA RNA NNP cord-018437-yjvwa1ot 303 4 serves serve VBZ cord-018437-yjvwa1ot 303 5 as as IN cord-018437-yjvwa1ot 303 6 template template NN cord-018437-yjvwa1ot 303 7 for for IN cord-018437-yjvwa1ot 303 8 synthesis synthesis NN cord-018437-yjvwa1ot 303 9 of of IN cord-018437-yjvwa1ot 303 10 mRNA mRNA NNP cord-018437-yjvwa1ot 303 11 and and CC cord-018437-yjvwa1ot 303 12 for for IN cord-018437-yjvwa1ot 303 13 synthesis synthesis NN cord-018437-yjvwa1ot 303 14 of of IN cord-018437-yjvwa1ot 303 15 antigenomic antigenomic FW cord-018437-yjvwa1ot 303 16 ( ( -LRB- cord-018437-yjvwa1ot 303 17 positive positive JJ cord-018437-yjvwa1ot 303 18 - - HYPH cord-018437-yjvwa1ot 303 19 sense sense NN cord-018437-yjvwa1ot 303 20 ) ) -RRB- cord-018437-yjvwa1ot 303 21 RNA RNA NNP cord-018437-yjvwa1ot 303 22 for for IN cord-018437-yjvwa1ot 303 23 synthesis synthesis NN cord-018437-yjvwa1ot 303 24 of of IN cord-018437-yjvwa1ot 303 25 new new JJ cord-018437-yjvwa1ot 303 26 viral viral JJ cord-018437-yjvwa1ot 303 27 negative negative JJ cord-018437-yjvwa1ot 303 28 - - HYPH cord-018437-yjvwa1ot 303 29 sense sense NN cord-018437-yjvwa1ot 303 30 RNA RNA NNP cord-018437-yjvwa1ot 303 31 for for IN cord-018437-yjvwa1ot 303 32 new new JJ cord-018437-yjvwa1ot 303 33 virions virion NNS cord-018437-yjvwa1ot 303 34 . . . cord-018437-yjvwa1ot 304 1 There there EX cord-018437-yjvwa1ot 304 2 are be VBP cord-018437-yjvwa1ot 304 3 six six CD cord-018437-yjvwa1ot 304 4 to to TO cord-018437-yjvwa1ot 304 5 ten ten CD cord-018437-yjvwa1ot 304 6 genes gene NNS cord-018437-yjvwa1ot 304 7 ; ; : cord-018437-yjvwa1ot 304 8 genes gene NNS cord-018437-yjvwa1ot 304 9 for for IN cord-018437-yjvwa1ot 304 10 the the DT cord-018437-yjvwa1ot 304 11 six six CD cord-018437-yjvwa1ot 304 12 major major JJ cord-018437-yjvwa1ot 304 13 proteins protein NNS cord-018437-yjvwa1ot 304 14 are be VBP cord-018437-yjvwa1ot 304 15 linked link VBN cord-018437-yjvwa1ot 304 16 in in IN cord-018437-yjvwa1ot 304 17 the the DT cord-018437-yjvwa1ot 304 18 following follow VBG cord-018437-yjvwa1ot 304 19 3′ 3′ CD cord-018437-yjvwa1ot 304 20 to to IN cord-018437-yjvwa1ot 304 21 5′ 5′ CD cord-018437-yjvwa1ot 304 22 order order NN cord-018437-yjvwa1ot 304 23 : : : cord-018437-yjvwa1ot 304 24 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 305 1 ( ( -LRB- cord-018437-yjvwa1ot 305 2 N N NNP cord-018437-yjvwa1ot 305 3 ) ) -RRB- cord-018437-yjvwa1ot 305 4 → → NN cord-018437-yjvwa1ot 305 5 phosphoprotein phosphoprotein NN cord-018437-yjvwa1ot 305 6 ( ( -LRB- cord-018437-yjvwa1ot 305 7 P p NN cord-018437-yjvwa1ot 305 8 ) ) -RRB- cord-018437-yjvwa1ot 305 9 → → NN cord-018437-yjvwa1ot 305 10 matrix matrix NN cord-018437-yjvwa1ot 305 11 ( ( -LRB- cord-018437-yjvwa1ot 305 12 M M NNP cord-018437-yjvwa1ot 305 13 ) ) -RRB- cord-018437-yjvwa1ot 306 1 → → SYM cord-018437-yjvwa1ot 306 2 fusion fusion NN cord-018437-yjvwa1ot 306 3 ( ( -LRB- cord-018437-yjvwa1ot 306 4 F f NN cord-018437-yjvwa1ot 306 5 ) ) -RRB- cord-018437-yjvwa1ot 307 1 → → IN cord-018437-yjvwa1ot 307 2 hemagglutinin hemagglutinin NN cord-018437-yjvwa1ot 307 3 / / SYM cord-018437-yjvwa1ot 307 4 neuraminidase neuraminidase NN cord-018437-yjvwa1ot 307 5 ( ( -LRB- cord-018437-yjvwa1ot 307 6 HN HN NNP cord-018437-yjvwa1ot 307 7 ) ) -RRB- cord-018437-yjvwa1ot 308 1 → → SYM cord-018437-yjvwa1ot 308 2 large large JJ cord-018437-yjvwa1ot 308 3 polymerase polymerase NN cord-018437-yjvwa1ot 308 4 ( ( -LRB- cord-018437-yjvwa1ot 308 5 L l NN cord-018437-yjvwa1ot 308 6 ) ) -RRB- cord-018437-yjvwa1ot 308 7 . . . cord-018437-yjvwa1ot 309 1 There there EX cord-018437-yjvwa1ot 309 2 is be VBZ cord-018437-yjvwa1ot 309 3 an an DT cord-018437-yjvwa1ot 309 4 untranslated untranslated JJ cord-018437-yjvwa1ot 309 5 leader leader NN cord-018437-yjvwa1ot 309 6 sequence sequence NN cord-018437-yjvwa1ot 309 7 at at IN cord-018437-yjvwa1ot 309 8 the the DT cord-018437-yjvwa1ot 309 9 3′ 3′ CD cord-018437-yjvwa1ot 309 10 end end NN cord-018437-yjvwa1ot 309 11 and and CC cord-018437-yjvwa1ot 309 12 untranslated untranslated JJ cord-018437-yjvwa1ot 309 13 trailer trailer NN cord-018437-yjvwa1ot 309 14 sequence sequence NN cord-018437-yjvwa1ot 309 15 at at IN cord-018437-yjvwa1ot 309 16 the the DT cord-018437-yjvwa1ot 309 17 5′ 5′ CD cord-018437-yjvwa1ot 309 18 end end NN cord-018437-yjvwa1ot 309 19 . . . cord-018437-yjvwa1ot 310 1 The the DT cord-018437-yjvwa1ot 310 2 genes gene NNS cord-018437-yjvwa1ot 310 3 are be VBP cord-018437-yjvwa1ot 310 4 separated separate VBN cord-018437-yjvwa1ot 310 5 by by IN cord-018437-yjvwa1ot 310 6 untranslated untranslated JJ cord-018437-yjvwa1ot 310 7 sequences sequence NNS cord-018437-yjvwa1ot 310 8 and and CC cord-018437-yjvwa1ot 310 9 do do VBP cord-018437-yjvwa1ot 310 10 not not RB cord-018437-yjvwa1ot 310 11 overlap overlap VB cord-018437-yjvwa1ot 310 12 , , , cord-018437-yjvwa1ot 310 13 with with IN cord-018437-yjvwa1ot 310 14 the the DT cord-018437-yjvwa1ot 310 15 exception exception NN cord-018437-yjvwa1ot 310 16 of of IN cord-018437-yjvwa1ot 310 17 the the DT cord-018437-yjvwa1ot 310 18 M M NNP cord-018437-yjvwa1ot 310 19 and and CC cord-018437-yjvwa1ot 310 20 L L NNP cord-018437-yjvwa1ot 310 21 genes gene NNS cord-018437-yjvwa1ot 310 22 of of IN cord-018437-yjvwa1ot 310 23 Human Human NNP cord-018437-yjvwa1ot 310 24 metapneumovirus metapneumovirus NNP cord-018437-yjvwa1ot 310 25 . . . cord-018437-yjvwa1ot 311 1 Translation translation NN cord-018437-yjvwa1ot 311 2 is be VBZ cord-018437-yjvwa1ot 311 3 initiated initiate VBN cord-018437-yjvwa1ot 311 4 at at IN cord-018437-yjvwa1ot 311 5 the the DT cord-018437-yjvwa1ot 311 6 3′ 3′ CD cord-018437-yjvwa1ot 311 7 end end NN cord-018437-yjvwa1ot 311 8 and and CC cord-018437-yjvwa1ot 311 9 proceeds proceed VBZ cord-018437-yjvwa1ot 311 10 directly directly RB cord-018437-yjvwa1ot 311 11 through through IN cord-018437-yjvwa1ot 311 12 to to IN cord-018437-yjvwa1ot 311 13 the the DT cord-018437-yjvwa1ot 311 14 5′ 5′ CD cord-018437-yjvwa1ot 311 15 end end NN cord-018437-yjvwa1ot 311 16 . . . cord-018437-yjvwa1ot 312 1 Because because IN cord-018437-yjvwa1ot 312 2 the the DT cord-018437-yjvwa1ot 312 3 RNA RNA NNP cord-018437-yjvwa1ot 312 4 polymerase polymerase NN cord-018437-yjvwa1ot 312 5 is be VBZ cord-018437-yjvwa1ot 312 6 unstable unstable JJ cord-018437-yjvwa1ot 312 7 and and CC cord-018437-yjvwa1ot 312 8 may may MD cord-018437-yjvwa1ot 312 9 detach detach VB cord-018437-yjvwa1ot 312 10 at at IN cord-018437-yjvwa1ot 312 11 the the DT cord-018437-yjvwa1ot 312 12 untranslated untranslated JJ cord-018437-yjvwa1ot 312 13 regions region NNS cord-018437-yjvwa1ot 312 14 between between IN cord-018437-yjvwa1ot 312 15 genes gene NNS cord-018437-yjvwa1ot 312 16 , , , cord-018437-yjvwa1ot 312 17 there there EX cord-018437-yjvwa1ot 312 18 is be VBZ cord-018437-yjvwa1ot 312 19 a a DT cord-018437-yjvwa1ot 312 20 gradient gradient NN cord-018437-yjvwa1ot 312 21 in in IN cord-018437-yjvwa1ot 312 22 the the DT cord-018437-yjvwa1ot 312 23 concentration concentration NN cord-018437-yjvwa1ot 312 24 of of IN cord-018437-yjvwa1ot 312 25 gene gene NN cord-018437-yjvwa1ot 312 26 products product NNS cord-018437-yjvwa1ot 312 27 from from IN cord-018437-yjvwa1ot 312 28 3′ 3′ CD cord-018437-yjvwa1ot 312 29 to to IN cord-018437-yjvwa1ot 312 30 5′. 5′. CD cord-018437-yjvwa1ot 313 1 In in IN cord-018437-yjvwa1ot 313 2 different different JJ cord-018437-yjvwa1ot 313 3 species specie NNS cord-018437-yjvwa1ot 313 4 , , , cord-018437-yjvwa1ot 313 5 other other JJ cord-018437-yjvwa1ot 313 6 proteins protein NNS cord-018437-yjvwa1ot 313 7 are be VBP cord-018437-yjvwa1ot 313 8 produced produce VBN cord-018437-yjvwa1ot 313 9 by by IN cord-018437-yjvwa1ot 313 10 additional additional JJ cord-018437-yjvwa1ot 313 11 small small JJ cord-018437-yjvwa1ot 313 12 genes gene NNS cord-018437-yjvwa1ot 313 13 , , , cord-018437-yjvwa1ot 313 14 mRNA mrna NN cord-018437-yjvwa1ot 313 15 editing editing NN cord-018437-yjvwa1ot 313 16 , , , cord-018437-yjvwa1ot 313 17 or or CC cord-018437-yjvwa1ot 313 18 overlapping overlap VBG cord-018437-yjvwa1ot 313 19 reading reading NN cord-018437-yjvwa1ot 313 20 frames frame NNS cord-018437-yjvwa1ot 313 21 within within IN cord-018437-yjvwa1ot 313 22 the the DT cord-018437-yjvwa1ot 313 23 P p NN cord-018437-yjvwa1ot 313 24 gene gene NN cord-018437-yjvwa1ot 313 25 . . . cord-018437-yjvwa1ot 314 1 The the DT cord-018437-yjvwa1ot 314 2 V v NN cord-018437-yjvwa1ot 314 3 and and CC cord-018437-yjvwa1ot 314 4 C c NN cord-018437-yjvwa1ot 314 5 proteins protein NNS cord-018437-yjvwa1ot 314 6 regulate regulate VBP cord-018437-yjvwa1ot 314 7 viral viral JJ cord-018437-yjvwa1ot 314 8 RNA rna NN cord-018437-yjvwa1ot 314 9 transcription transcription NN cord-018437-yjvwa1ot 314 10 and and CC cord-018437-yjvwa1ot 314 11 also also RB cord-018437-yjvwa1ot 314 12 interfere interfere VB cord-018437-yjvwa1ot 314 13 with with IN cord-018437-yjvwa1ot 314 14 host host NN cord-018437-yjvwa1ot 314 15 interferon interferon NN cord-018437-yjvwa1ot 314 16 signaling signal VBG cord-018437-yjvwa1ot 314 17 and and CC cord-018437-yjvwa1ot 314 18 other other JJ cord-018437-yjvwa1ot 314 19 aspects aspect NNS cord-018437-yjvwa1ot 314 20 of of IN cord-018437-yjvwa1ot 314 21 the the DT cord-018437-yjvwa1ot 314 22 immune immune JJ cord-018437-yjvwa1ot 314 23 response response NN cord-018437-yjvwa1ot 314 24 to to IN cord-018437-yjvwa1ot 314 25 paramyxovirus paramyxovirus JJ cord-018437-yjvwa1ot 314 26 infection infection NN cord-018437-yjvwa1ot 315 1 ( ( -LRB- cord-018437-yjvwa1ot 315 2 Andrejeva Andrejeva NNP cord-018437-yjvwa1ot 315 3 et et NNP cord-018437-yjvwa1ot 315 4 al al NNP cord-018437-yjvwa1ot 315 5 . . . cord-018437-yjvwa1ot 316 1 2004 2004 CD cord-018437-yjvwa1ot 316 2 ; ; : cord-018437-yjvwa1ot 316 3 Durbin Durbin NNP cord-018437-yjvwa1ot 316 4 et et NNP cord-018437-yjvwa1ot 316 5 al al NNP cord-018437-yjvwa1ot 316 6 . . . cord-018437-yjvwa1ot 317 1 1999 1999 CD cord-018437-yjvwa1ot 317 2 ; ; : cord-018437-yjvwa1ot 317 3 Swedan Swedan NNP cord-018437-yjvwa1ot 317 4 et et FW cord-018437-yjvwa1ot 317 5 al al NNP cord-018437-yjvwa1ot 317 6 . . NNP cord-018437-yjvwa1ot 317 7 2009 2009 CD cord-018437-yjvwa1ot 317 8 ) ) -RRB- cord-018437-yjvwa1ot 317 9 . . . cord-018437-yjvwa1ot 318 1 Formation formation NN cord-018437-yjvwa1ot 318 2 of of IN cord-018437-yjvwa1ot 318 3 the the DT cord-018437-yjvwa1ot 318 4 nucleocapsid nucleocapsid NNP cord-018437-yjvwa1ot 318 5 core core NN cord-018437-yjvwa1ot 318 6 is be VBZ cord-018437-yjvwa1ot 318 7 constrained constrain VBN cord-018437-yjvwa1ot 318 8 by by IN cord-018437-yjvwa1ot 318 9 a a DT cord-018437-yjvwa1ot 318 10 required require VBN cord-018437-yjvwa1ot 318 11 association association NN cord-018437-yjvwa1ot 318 12 of of IN cord-018437-yjvwa1ot 318 13 one one CD cord-018437-yjvwa1ot 318 14 N n CD cord-018437-yjvwa1ot 318 15 protein protein NN cord-018437-yjvwa1ot 318 16 to to IN cord-018437-yjvwa1ot 318 17 every every DT cord-018437-yjvwa1ot 318 18 six six CD cord-018437-yjvwa1ot 318 19 genomic genomic JJ cord-018437-yjvwa1ot 318 20 nucleotides nucleotide NNS cord-018437-yjvwa1ot 319 1 ( ( -LRB- cord-018437-yjvwa1ot 319 2 Kolakofsky Kolakofsky NNP cord-018437-yjvwa1ot 319 3 et et NNP cord-018437-yjvwa1ot 319 4 al al NNP cord-018437-yjvwa1ot 319 5 . . . cord-018437-yjvwa1ot 320 1 2005 2005 CD cord-018437-yjvwa1ot 320 2 ; ; : cord-018437-yjvwa1ot 320 3 Skiadopoulos Skiadopoulos NNP cord-018437-yjvwa1ot 320 4 et et NNP cord-018437-yjvwa1ot 320 5 al al NNP cord-018437-yjvwa1ot 320 6 . . NNP cord-018437-yjvwa1ot 320 7 2003 2003 CD cord-018437-yjvwa1ot 320 8 ) ) -RRB- cord-018437-yjvwa1ot 320 9 . . . cord-018437-yjvwa1ot 321 1 The the DT cord-018437-yjvwa1ot 321 2 resulting result VBG cord-018437-yjvwa1ot 321 3 helical helical JJ cord-018437-yjvwa1ot 321 4 structure structure NN cord-018437-yjvwa1ot 321 5 has have VBZ cord-018437-yjvwa1ot 321 6 a a DT cord-018437-yjvwa1ot 321 7 diameter diameter NN cord-018437-yjvwa1ot 321 8 of of IN cord-018437-yjvwa1ot 321 9 18 18 CD cord-018437-yjvwa1ot 321 10 nm nm NN cord-018437-yjvwa1ot 321 11 with with IN cord-018437-yjvwa1ot 321 12 a a DT cord-018437-yjvwa1ot 321 13 4 4 CD cord-018437-yjvwa1ot 321 14 nm nm NNP cord-018437-yjvwa1ot 321 15 central central JJ cord-018437-yjvwa1ot 321 16 core core NN cord-018437-yjvwa1ot 321 17 . . . cord-018437-yjvwa1ot 322 1 P p NN cord-018437-yjvwa1ot 322 2 proteins protein NNS cord-018437-yjvwa1ot 322 3 ( ( -LRB- cord-018437-yjvwa1ot 322 4 a a DT cord-018437-yjvwa1ot 322 5 polymerase polymerase NN cord-018437-yjvwa1ot 322 6 cofactor cofactor NN cord-018437-yjvwa1ot 322 7 ) ) -RRB- cord-018437-yjvwa1ot 322 8 are be VBP cord-018437-yjvwa1ot 322 9 attached attach VBN cord-018437-yjvwa1ot 322 10 to to IN cord-018437-yjvwa1ot 322 11 this this DT cord-018437-yjvwa1ot 322 12 rigid rigid JJ cord-018437-yjvwa1ot 322 13 rod rod NN cord-018437-yjvwa1ot 322 14 and and CC cord-018437-yjvwa1ot 322 15 serve serve VBP cord-018437-yjvwa1ot 322 16 as as IN cord-018437-yjvwa1ot 322 17 attachment attachment NN cord-018437-yjvwa1ot 322 18 of of IN cord-018437-yjvwa1ot 322 19 L l NN cord-018437-yjvwa1ot 322 20 proteins protein NNS cord-018437-yjvwa1ot 322 21 , , , cord-018437-yjvwa1ot 322 22 which which WDT cord-018437-yjvwa1ot 322 23 interact interact VBP cord-018437-yjvwa1ot 322 24 to to TO cord-018437-yjvwa1ot 322 25 provide provide VB cord-018437-yjvwa1ot 322 26 enzymatic enzymatic JJ cord-018437-yjvwa1ot 322 27 activity activity NN cord-018437-yjvwa1ot 322 28 for for IN cord-018437-yjvwa1ot 322 29 RNA RNA NNP cord-018437-yjvwa1ot 322 30 synthesis synthesis NN cord-018437-yjvwa1ot 322 31 . . . cord-018437-yjvwa1ot 323 1 This this DT cord-018437-yjvwa1ot 323 2 core core NN cord-018437-yjvwa1ot 323 3 structure structure NN cord-018437-yjvwa1ot 323 4 , , , cord-018437-yjvwa1ot 323 5 rather rather RB cord-018437-yjvwa1ot 323 6 than than IN cord-018437-yjvwa1ot 323 7 free free JJ cord-018437-yjvwa1ot 323 8 genomic genomic JJ cord-018437-yjvwa1ot 323 9 RNA RNA NNP cord-018437-yjvwa1ot 323 10 , , , cord-018437-yjvwa1ot 323 11 serves serve VBZ cord-018437-yjvwa1ot 323 12 as as IN cord-018437-yjvwa1ot 323 13 the the DT cord-018437-yjvwa1ot 323 14 template template NN cord-018437-yjvwa1ot 323 15 for for IN cord-018437-yjvwa1ot 323 16 mRNA mRNA NNP cord-018437-yjvwa1ot 323 17 and and CC cord-018437-yjvwa1ot 323 18 antigenomic antigenomic NNP cord-018437-yjvwa1ot 323 19 RNA RNA NNP cord-018437-yjvwa1ot 323 20 synthesis synthesis NN cord-018437-yjvwa1ot 323 21 . . . cord-018437-yjvwa1ot 324 1 The the DT cord-018437-yjvwa1ot 324 2 paramyxovirus paramyxovirus NNP cord-018437-yjvwa1ot 324 3 M M NNP cord-018437-yjvwa1ot 324 4 proteins protein NNS cord-018437-yjvwa1ot 324 5 surround surround VBP cord-018437-yjvwa1ot 324 6 and and CC cord-018437-yjvwa1ot 324 7 organize organize VBP cord-018437-yjvwa1ot 324 8 the the DT cord-018437-yjvwa1ot 324 9 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 324 10 and and CC cord-018437-yjvwa1ot 324 11 interact interact VB cord-018437-yjvwa1ot 324 12 with with IN cord-018437-yjvwa1ot 324 13 the the DT cord-018437-yjvwa1ot 324 14 cytoplasmic cytoplasmic JJ cord-018437-yjvwa1ot 324 15 tails tail NNS cord-018437-yjvwa1ot 324 16 of of IN cord-018437-yjvwa1ot 324 17 transmembrane transmembrane NN cord-018437-yjvwa1ot 324 18 envelope envelope NN cord-018437-yjvwa1ot 324 19 proteins protein NNS cord-018437-yjvwa1ot 324 20 . . . cord-018437-yjvwa1ot 325 1 The the DT cord-018437-yjvwa1ot 325 2 envelope envelope NN cord-018437-yjvwa1ot 325 3 formed form VBN cord-018437-yjvwa1ot 325 4 from from IN cord-018437-yjvwa1ot 325 5 modifi modifi NNP cord-018437-yjvwa1ot 325 6 ed ed NNP cord-018437-yjvwa1ot 325 7 host host NN cord-018437-yjvwa1ot 325 8 - - HYPH cord-018437-yjvwa1ot 325 9 cell cell NN cord-018437-yjvwa1ot 325 10 plasma plasma NN cord-018437-yjvwa1ot 325 11 membranes membrane NNS cord-018437-yjvwa1ot 325 12 is be VBZ cord-018437-yjvwa1ot 325 13 studded stud VBN cord-018437-yjvwa1ot 325 14 by by IN cord-018437-yjvwa1ot 325 15 viral viral JJ cord-018437-yjvwa1ot 325 16 protein protein NN cord-018437-yjvwa1ot 325 17 complexes complex NNS cord-018437-yjvwa1ot 325 18 , , , cord-018437-yjvwa1ot 325 19 including include VBG cord-018437-yjvwa1ot 325 20 HN HN NNP cord-018437-yjvwa1ot 325 21 proteins protein NNS cord-018437-yjvwa1ot 325 22 , , , cord-018437-yjvwa1ot 325 23 which which WDT cord-018437-yjvwa1ot 325 24 mediate mediate VBP cord-018437-yjvwa1ot 325 25 virion virion NN cord-018437-yjvwa1ot 325 26 attachment attachment NN cord-018437-yjvwa1ot 325 27 to to TO cord-018437-yjvwa1ot 325 28 target target VB cord-018437-yjvwa1ot 325 29 cells cell NNS cord-018437-yjvwa1ot 325 30 , , , cord-018437-yjvwa1ot 325 31 and and CC cord-018437-yjvwa1ot 325 32 F F NNP cord-018437-yjvwa1ot 325 33 protein protein NN cord-018437-yjvwa1ot 325 34 , , , cord-018437-yjvwa1ot 325 35 which which WDT cord-018437-yjvwa1ot 325 36 mediates mediate VBZ cord-018437-yjvwa1ot 325 37 pH ph NN cord-018437-yjvwa1ot 325 38 - - JJ cord-018437-yjvwa1ot 325 39 independent independent JJ cord-018437-yjvwa1ot 325 40 fusion fusion NN cord-018437-yjvwa1ot 325 41 of of IN cord-018437-yjvwa1ot 325 42 the the DT cord-018437-yjvwa1ot 325 43 viral viral JJ cord-018437-yjvwa1ot 325 44 envelope envelope NN cord-018437-yjvwa1ot 325 45 and and CC cord-018437-yjvwa1ot 325 46 cell cell NN cord-018437-yjvwa1ot 325 47 cytoplasmic cytoplasmic JJ cord-018437-yjvwa1ot 325 48 membrane membrane NN cord-018437-yjvwa1ot 325 49 . . . cord-018437-yjvwa1ot 326 1 The the DT cord-018437-yjvwa1ot 326 2 Paramyxoviridae Paramyxoviridae NNP cord-018437-yjvwa1ot 326 3 are be VBP cord-018437-yjvwa1ot 326 4 one one CD cord-018437-yjvwa1ot 326 5 of of IN cord-018437-yjvwa1ot 326 6 the the DT cord-018437-yjvwa1ot 326 7 four four CD cord-018437-yjvwa1ot 326 8 families family NNS cord-018437-yjvwa1ot 326 9 within within IN cord-018437-yjvwa1ot 326 10 the the DT cord-018437-yjvwa1ot 326 11 order order NN cord-018437-yjvwa1ot 326 12 Mononegavirales Mononegavirales NNPS cord-018437-yjvwa1ot 326 13 and and CC cord-018437-yjvwa1ot 326 14 include include VBP cord-018437-yjvwa1ot 326 15 signifi signifi NNP cord-018437-yjvwa1ot 326 16 ca can MD cord-018437-yjvwa1ot 326 17 nt not RB cord-018437-yjvwa1ot 326 18 and and CC cord-018437-yjvwa1ot 326 19 frequent frequent JJ cord-018437-yjvwa1ot 326 20 pathogens pathogen NNS cord-018437-yjvwa1ot 326 21 of of IN cord-018437-yjvwa1ot 326 22 humans human NNS cord-018437-yjvwa1ot 326 23 and and CC cord-018437-yjvwa1ot 326 24 animals animal NNS cord-018437-yjvwa1ot 326 25 . . . cord-018437-yjvwa1ot 327 1 There there EX cord-018437-yjvwa1ot 327 2 are be VBP cord-018437-yjvwa1ot 327 3 two two CD cord-018437-yjvwa1ot 327 4 subfamilies subfamily NNS cord-018437-yjvwa1ot 327 5 : : : cord-018437-yjvwa1ot 327 6 the the DT cord-018437-yjvwa1ot 327 7 Paramyxovirinae Paramyxovirinae NNP cord-018437-yjvwa1ot 327 8 and and CC cord-018437-yjvwa1ot 327 9 the the DT cord-018437-yjvwa1ot 327 10 Pneumovirinae Pneumovirinae NNP cord-018437-yjvwa1ot 327 11 . . . cord-018437-yjvwa1ot 328 1 There there EX cord-018437-yjvwa1ot 328 2 are be VBP cord-018437-yjvwa1ot 328 3 seven seven CD cord-018437-yjvwa1ot 328 4 genera genus NNS cord-018437-yjvwa1ot 328 5 and and CC cord-018437-yjvwa1ot 328 6 thirty thirty CD cord-018437-yjvwa1ot 328 7 - - HYPH cord-018437-yjvwa1ot 328 8 one one CD cord-018437-yjvwa1ot 328 9 species specie NNS cord-018437-yjvwa1ot 328 10 in in IN cord-018437-yjvwa1ot 328 11 the the DT cord-018437-yjvwa1ot 328 12 subfamily subfamily NN cord-018437-yjvwa1ot 328 13 Paramyxovirinae Paramyxovirinae NNP cord-018437-yjvwa1ot 328 14 and and CC cord-018437-yjvwa1ot 328 15 two two CD cord-018437-yjvwa1ot 328 16 genera genus NNS cord-018437-yjvwa1ot 328 17 and and CC cord-018437-yjvwa1ot 328 18 fi fi NN cord-018437-yjvwa1ot 329 1 ve ve VBD cord-018437-yjvwa1ot 329 2 species specie NNS cord-018437-yjvwa1ot 329 3 in in IN cord-018437-yjvwa1ot 329 4 the the DT cord-018437-yjvwa1ot 329 5 Pneumovirinae Pneumovirinae NNP cord-018437-yjvwa1ot 329 6 subfamily subfamily NN cord-018437-yjvwa1ot 329 7 . . . cord-018437-yjvwa1ot 330 1 • • NNP cord-018437-yjvwa1ot 331 1 Henipahviruses Henipahviruses NNP cord-018437-yjvwa1ot 331 2 : : : cord-018437-yjvwa1ot 332 1 In in IN cord-018437-yjvwa1ot 332 2 the the DT cord-018437-yjvwa1ot 332 3 subfamily subfamily NN cord-018437-yjvwa1ot 332 4 Paramyxovirinae Paramyxovirinae NNP cord-018437-yjvwa1ot 332 5 , , , cord-018437-yjvwa1ot 332 6 there there EX cord-018437-yjvwa1ot 332 7 are be VBP cord-018437-yjvwa1ot 332 8 two two CD cord-018437-yjvwa1ot 332 9 species specie NNS cord-018437-yjvwa1ot 332 10 within within IN cord-018437-yjvwa1ot 332 11 the the DT cord-018437-yjvwa1ot 332 12 genus genus NN cord-018437-yjvwa1ot 333 1 Henipahvirus Henipahvirus NNP cord-018437-yjvwa1ot 333 2 : : : cord-018437-yjvwa1ot 333 3 Hendra Hendra NNP cord-018437-yjvwa1ot 333 4 virus virus NN cord-018437-yjvwa1ot 333 5 ( ( -LRB- cord-018437-yjvwa1ot 333 6 HeV hev NN cord-018437-yjvwa1ot 333 7 ) ) -RRB- cord-018437-yjvwa1ot 333 8 and and CC cord-018437-yjvwa1ot 333 9 Nipah Nipah NNP cord-018437-yjvwa1ot 333 10 virus virus NN cord-018437-yjvwa1ot 333 11 ( ( -LRB- cord-018437-yjvwa1ot 333 12 NiV niv NN cord-018437-yjvwa1ot 333 13 ) ) -RRB- cord-018437-yjvwa1ot 334 1 ; ; : cord-018437-yjvwa1ot 334 2 HeV HeV NNP cord-018437-yjvwa1ot 334 3 is be VBZ cord-018437-yjvwa1ot 334 4 the the DT cord-018437-yjvwa1ot 334 5 type type NN cord-018437-yjvwa1ot 334 6 species specie NNS cord-018437-yjvwa1ot 334 7 . . . cord-018437-yjvwa1ot 335 1 Henipahvirus Henipahvirus NNP cord-018437-yjvwa1ot 335 2 virions virion NNS cord-018437-yjvwa1ot 335 3 are be VBP cord-018437-yjvwa1ot 335 4 pleomorphic pleomorphic JJ cord-018437-yjvwa1ot 335 5 ( ( -LRB- cord-018437-yjvwa1ot 335 6 spherical spherical JJ cord-018437-yjvwa1ot 335 7 to to IN cord-018437-yjvwa1ot 335 8 helical helical JJ cord-018437-yjvwa1ot 335 9 forms form NNS cord-018437-yjvwa1ot 335 10 ) ) -RRB- cord-018437-yjvwa1ot 335 11 . . . cord-018437-yjvwa1ot 336 1 Electron electron NN cord-018437-yjvwa1ot 336 2 microscopy microscopy NN cord-018437-yjvwa1ot 336 3 of of IN cord-018437-yjvwa1ot 336 4 Hendra Hendra NNP cord-018437-yjvwa1ot 336 5 virus virus NN cord-018437-yjvwa1ot 336 6 shows show VBZ cord-018437-yjvwa1ot 336 7 a a DT cord-018437-yjvwa1ot 336 8 " " `` cord-018437-yjvwa1ot 336 9 double double JJ cord-018437-yjvwa1ot 336 10 - - HYPH cord-018437-yjvwa1ot 336 11 fringe fringe NN cord-018437-yjvwa1ot 336 12 " " '' cord-018437-yjvwa1ot 336 13 appearance appearance NN cord-018437-yjvwa1ot 336 14 due due IN cord-018437-yjvwa1ot 336 15 to to IN cord-018437-yjvwa1ot 336 16 short short JJ cord-018437-yjvwa1ot 336 17 and and CC cord-018437-yjvwa1ot 336 18 long long JJ cord-018437-yjvwa1ot 336 19 surface surface NN cord-018437-yjvwa1ot 336 20 projections projection NNS cord-018437-yjvwa1ot 336 21 ( ( -LRB- cord-018437-yjvwa1ot 336 22 Hyatt Hyatt NNP cord-018437-yjvwa1ot 336 23 et et NNP cord-018437-yjvwa1ot 336 24 al al NNP cord-018437-yjvwa1ot 336 25 . . NNP cord-018437-yjvwa1ot 336 26 2001 2001 CD cord-018437-yjvwa1ot 336 27 ) ) -RRB- cord-018437-yjvwa1ot 336 28 . . . cord-018437-yjvwa1ot 337 1 Complete complete JJ cord-018437-yjvwa1ot 337 2 virions virion NNS cord-018437-yjvwa1ot 337 3 range range VBP cord-018437-yjvwa1ot 337 4 in in IN cord-018437-yjvwa1ot 337 5 size size NN cord-018437-yjvwa1ot 337 6 from from IN cord-018437-yjvwa1ot 337 7 40 40 CD cord-018437-yjvwa1ot 337 8 to to TO cord-018437-yjvwa1ot 337 9 1,900 1,900 CD cord-018437-yjvwa1ot 337 10 nm nm CD cord-018437-yjvwa1ot 337 11 in in IN cord-018437-yjvwa1ot 337 12 longest long JJS cord-018437-yjvwa1ot 337 13 dimension dimension NN cord-018437-yjvwa1ot 337 14 . . . cord-018437-yjvwa1ot 338 1 The the DT cord-018437-yjvwa1ot 338 2 genome genome NN cord-018437-yjvwa1ot 338 3 ( ( -LRB- cord-018437-yjvwa1ot 338 4 ~18 ~18 NFP cord-018437-yjvwa1ot 338 5 kb kb NNP cord-018437-yjvwa1ot 338 6 ) ) -RRB- cord-018437-yjvwa1ot 338 7 includes include VBZ cord-018437-yjvwa1ot 338 8 genes gene NNS cord-018437-yjvwa1ot 338 9 typical typical JJ cord-018437-yjvwa1ot 338 10 of of IN cord-018437-yjvwa1ot 338 11 Paramyxoviridae Paramyxoviridae NNP cord-018437-yjvwa1ot 338 12 . . . cord-018437-yjvwa1ot 339 1 Long long JJ cord-018437-yjvwa1ot 339 2 untranslated untranslated JJ cord-018437-yjvwa1ot 339 3 sequences sequence NNS cord-018437-yjvwa1ot 339 4 are be VBP cord-018437-yjvwa1ot 339 5 attached attach VBN cord-018437-yjvwa1ot 339 6 to to IN cord-018437-yjvwa1ot 339 7 the the DT cord-018437-yjvwa1ot 339 8 3′ 3′ CD cord-018437-yjvwa1ot 339 9 end end NN cord-018437-yjvwa1ot 339 10 of of IN cord-018437-yjvwa1ot 339 11 fi fi NN cord-018437-yjvwa1ot 339 12 ve ve FW cord-018437-yjvwa1ot 339 13 of of IN cord-018437-yjvwa1ot 339 14 the the DT cord-018437-yjvwa1ot 339 15 six six CD cord-018437-yjvwa1ot 339 16 genes gene NNS cord-018437-yjvwa1ot 339 17 , , , cord-018437-yjvwa1ot 339 18 resulting result VBG cord-018437-yjvwa1ot 339 19 in in IN cord-018437-yjvwa1ot 339 20 the the DT cord-018437-yjvwa1ot 339 21 larger large JJR cord-018437-yjvwa1ot 339 22 genome genome NN cord-018437-yjvwa1ot 339 23 size size NN cord-018437-yjvwa1ot 339 24 of of IN cord-018437-yjvwa1ot 339 25 Henipahviruses Henipahviruses NNP cord-018437-yjvwa1ot 339 26 compared compare VBN cord-018437-yjvwa1ot 339 27 to to IN cord-018437-yjvwa1ot 339 28 other other JJ cord-018437-yjvwa1ot 339 29 Paramyxoviruses paramyxovirus NNS cord-018437-yjvwa1ot 340 1 ( ( -LRB- cord-018437-yjvwa1ot 340 2 Eaton Eaton NNP cord-018437-yjvwa1ot 340 3 et et NNP cord-018437-yjvwa1ot 340 4 al al NNP cord-018437-yjvwa1ot 340 5 . . . cord-018437-yjvwa1ot 341 1 2007 2007 CD cord-018437-yjvwa1ot 341 2 ; ; : cord-018437-yjvwa1ot 341 3 Wang Wang NNP cord-018437-yjvwa1ot 341 4 et et NNP cord-018437-yjvwa1ot 341 5 al al NNP cord-018437-yjvwa1ot 341 6 . . . cord-018437-yjvwa1ot 341 7 2000 2000 CD cord-018437-yjvwa1ot 341 8 ) ) -RRB- cord-018437-yjvwa1ot 341 9 . . . cord-018437-yjvwa1ot 342 1 The the DT cord-018437-yjvwa1ot 342 2 P p NN cord-018437-yjvwa1ot 342 3 gene gene NN cord-018437-yjvwa1ot 342 4 also also RB cord-018437-yjvwa1ot 342 5 codes code VBZ cord-018437-yjvwa1ot 342 6 for for IN cord-018437-yjvwa1ot 342 7 V V NNP cord-018437-yjvwa1ot 342 8 and and CC cord-018437-yjvwa1ot 342 9 W w NN cord-018437-yjvwa1ot 342 10 proteins protein NNS cord-018437-yjvwa1ot 342 11 by by IN cord-018437-yjvwa1ot 342 12 mRNA mrna NN cord-018437-yjvwa1ot 342 13 editing editing NN cord-018437-yjvwa1ot 342 14 and and CC cord-018437-yjvwa1ot 342 15 C C NNP cord-018437-yjvwa1ot 342 16 protein protein NN cord-018437-yjvwa1ot 342 17 by by IN cord-018437-yjvwa1ot 342 18 a a DT cord-018437-yjvwa1ot 342 19 shifted shift VBN cord-018437-yjvwa1ot 342 20 reading reading NN cord-018437-yjvwa1ot 342 21 frame frame NN cord-018437-yjvwa1ot 342 22 . . . cord-018437-yjvwa1ot 343 1 Henipahviruses Henipahviruses NNP cord-018437-yjvwa1ot 343 2 are be VBP cord-018437-yjvwa1ot 343 3 assigned assign VBN cord-018437-yjvwa1ot 343 4 to to IN cord-018437-yjvwa1ot 343 5 the the DT cord-018437-yjvwa1ot 343 6 family family NN cord-018437-yjvwa1ot 343 7 Paramyxoviridae Paramyxoviridae NNP cord-018437-yjvwa1ot 343 8 and and CC cord-018437-yjvwa1ot 343 9 subfamily subfamily RB cord-018437-yjvwa1ot 343 10 Paramyxovirinae Paramyxovirinae NNP cord-018437-yjvwa1ot 343 11 . . . cord-018437-yjvwa1ot 344 1 Henipahvirus henipahvirus JJ cord-018437-yjvwa1ot 344 2 infections infection NNS cord-018437-yjvwa1ot 344 3 are be VBP cord-018437-yjvwa1ot 344 4 zoonotic zoonotic JJ cord-018437-yjvwa1ot 344 5 ; ; : cord-018437-yjvwa1ot 344 6 fruit fruit NN cord-018437-yjvwa1ot 344 7 bats bat NNS cord-018437-yjvwa1ot 344 8 are be VBP cord-018437-yjvwa1ot 344 9 the the DT cord-018437-yjvwa1ot 344 10 presumed presume VBN cord-018437-yjvwa1ot 344 11 reservoir reservoir NN cord-018437-yjvwa1ot 344 12 for for IN cord-018437-yjvwa1ot 344 13 Hendra Hendra NNP cord-018437-yjvwa1ot 344 14 virus virus NN cord-018437-yjvwa1ot 344 15 infections infection NNS cord-018437-yjvwa1ot 344 16 , , , cord-018437-yjvwa1ot 344 17 while while IN cord-018437-yjvwa1ot 344 18 fruit fruit NN cord-018437-yjvwa1ot 344 19 bats bat NNS cord-018437-yjvwa1ot 344 20 ( ( -LRB- cord-018437-yjvwa1ot 344 21 Johara Johara NNP cord-018437-yjvwa1ot 344 22 et et FW cord-018437-yjvwa1ot 344 23 al al NNP cord-018437-yjvwa1ot 344 24 . . NNP cord-018437-yjvwa1ot 344 25 2001 2001 CD cord-018437-yjvwa1ot 344 26 ) ) -RRB- cord-018437-yjvwa1ot 344 27 includes include VBZ cord-018437-yjvwa1ot 344 28 two two CD cord-018437-yjvwa1ot 344 29 open open JJ cord-018437-yjvwa1ot 344 30 reading reading NN cord-018437-yjvwa1ot 344 31 frames frame NNS cord-018437-yjvwa1ot 344 32 ; ; : cord-018437-yjvwa1ot 344 33 the the DT cord-018437-yjvwa1ot 344 34 function function NN cord-018437-yjvwa1ot 344 35 of of IN cord-018437-yjvwa1ot 344 36 M2 M2 NNP cord-018437-yjvwa1ot 344 37 - - SYM cord-018437-yjvwa1ot 344 38 1 1 CD cord-018437-yjvwa1ot 344 39 protein protein NN cord-018437-yjvwa1ot 344 40 is be VBZ cord-018437-yjvwa1ot 344 41 undefi undefi JJ cord-018437-yjvwa1ot 344 42 ned ned NNP cord-018437-yjvwa1ot 344 43 , , , cord-018437-yjvwa1ot 344 44 while while IN cord-018437-yjvwa1ot 344 45 M2 M2 NNP cord-018437-yjvwa1ot 344 46 - - SYM cord-018437-yjvwa1ot 344 47 2 2 CD cord-018437-yjvwa1ot 344 48 protein protein NN cord-018437-yjvwa1ot 344 49 is be VBZ cord-018437-yjvwa1ot 344 50 a a DT cord-018437-yjvwa1ot 344 51 regulator regulator NN cord-018437-yjvwa1ot 344 52 of of IN cord-018437-yjvwa1ot 344 53 viral viral JJ cord-018437-yjvwa1ot 344 54 transcription transcription NN cord-018437-yjvwa1ot 344 55 . . . cord-018437-yjvwa1ot 345 1 There there EX cord-018437-yjvwa1ot 345 2 is be VBZ cord-018437-yjvwa1ot 345 3 no no DT cord-018437-yjvwa1ot 345 4 gene gene NN cord-018437-yjvwa1ot 345 5 for for IN cord-018437-yjvwa1ot 345 6 hemagglutinin hemagglutinin NN cord-018437-yjvwa1ot 345 7 - - HYPH cord-018437-yjvwa1ot 345 8 neuraminidase neuraminidase NN cord-018437-yjvwa1ot 345 9 ; ; : cord-018437-yjvwa1ot 345 10 the the DT cord-018437-yjvwa1ot 345 11 product product NN cord-018437-yjvwa1ot 345 12 of of IN cord-018437-yjvwa1ot 345 13 the the DT cord-018437-yjvwa1ot 345 14 G g NN cord-018437-yjvwa1ot 345 15 gene gene NN cord-018437-yjvwa1ot 345 16 serves serve VBZ cord-018437-yjvwa1ot 345 17 as as IN cord-018437-yjvwa1ot 345 18 the the DT cord-018437-yjvwa1ot 345 19 major major JJ cord-018437-yjvwa1ot 345 20 attachment attachment NN cord-018437-yjvwa1ot 345 21 protein protein NN cord-018437-yjvwa1ot 345 22 . . . cord-018437-yjvwa1ot 346 1 Metapneumoviruses metapneumoviruse NNS cord-018437-yjvwa1ot 346 2 are be VBP cord-018437-yjvwa1ot 346 3 members member NNS cord-018437-yjvwa1ot 346 4 of of IN cord-018437-yjvwa1ot 346 5 the the DT cord-018437-yjvwa1ot 346 6 subfamily subfamily NN cord-018437-yjvwa1ot 346 7 Pneumovirinae Pneumovirinae NNP cord-018437-yjvwa1ot 346 8 . . . cord-018437-yjvwa1ot 347 1 Human Human NNP cord-018437-yjvwa1ot 347 2 metapneumovirus metapneumovirus NNP cord-018437-yjvwa1ot 347 3 is be VBZ cord-018437-yjvwa1ot 347 4 a a DT cord-018437-yjvwa1ot 347 5 species species NN cord-018437-yjvwa1ot 347 6 in in IN cord-018437-yjvwa1ot 347 7 the the DT cord-018437-yjvwa1ot 347 8 genus genus NN cord-018437-yjvwa1ot 347 9 Metapneumovirus Metapneumovirus NNP cord-018437-yjvwa1ot 347 10 . . . cord-018437-yjvwa1ot 348 1 There there EX cord-018437-yjvwa1ot 348 2 is be VBZ cord-018437-yjvwa1ot 348 3 a a DT cord-018437-yjvwa1ot 348 4 single single JJ cord-018437-yjvwa1ot 348 5 hMPV hmpv NN cord-018437-yjvwa1ot 348 6 serotype serotype NN cord-018437-yjvwa1ot 348 7 , , , cord-018437-yjvwa1ot 348 8 with with IN cord-018437-yjvwa1ot 348 9 two two CD cord-018437-yjvwa1ot 348 10 antigenic antigenic JJ cord-018437-yjvwa1ot 348 11 subtypes subtype NNS cord-018437-yjvwa1ot 348 12 A A NNP cord-018437-yjvwa1ot 348 13 and and CC cord-018437-yjvwa1ot 348 14 B. B. NNP cord-018437-yjvwa1ot 348 15 • • NNP cord-018437-yjvwa1ot 348 16 Human Human NNP cord-018437-yjvwa1ot 348 17 Respiratory respiratory JJ cord-018437-yjvwa1ot 348 18 Syncytial syncytial JJ cord-018437-yjvwa1ot 348 19 Viruses virus NNS cord-018437-yjvwa1ot 348 20 : : : cord-018437-yjvwa1ot 349 1 The the DT cord-018437-yjvwa1ot 349 2 envelope envelope NN cord-018437-yjvwa1ot 349 3 of of IN cord-018437-yjvwa1ot 349 4 Human human JJ cord-018437-yjvwa1ot 349 5 respiratory respiratory JJ cord-018437-yjvwa1ot 349 6 syncytial syncytial JJ cord-018437-yjvwa1ot 349 7 virus virus NN cord-018437-yjvwa1ot 349 8 ( ( -LRB- cord-018437-yjvwa1ot 349 9 hRSV hRSV NNP cord-018437-yjvwa1ot 349 10 ) ) -RRB- cord-018437-yjvwa1ot 349 11 is be VBZ cord-018437-yjvwa1ot 349 12 studded stud VBN cord-018437-yjvwa1ot 349 13 with with IN cord-018437-yjvwa1ot 349 14 three three CD cord-018437-yjvwa1ot 349 15 viral viral JJ cord-018437-yjvwa1ot 349 16 glycoproteins glycoprotein NNS cord-018437-yjvwa1ot 349 17 : : : cord-018437-yjvwa1ot 349 18 G g NN cord-018437-yjvwa1ot 349 19 protein protein NN cord-018437-yjvwa1ot 349 20 ( ( -LRB- cord-018437-yjvwa1ot 349 21 the the DT cord-018437-yjvwa1ot 349 22 major major JJ cord-018437-yjvwa1ot 349 23 attachment attachment NN cord-018437-yjvwa1ot 349 24 protein protein NN cord-018437-yjvwa1ot 349 25 ) ) -RRB- cord-018437-yjvwa1ot 349 26 , , , cord-018437-yjvwa1ot 349 27 F F NNP cord-018437-yjvwa1ot 349 28 protein protein NN cord-018437-yjvwa1ot 349 29 , , , cord-018437-yjvwa1ot 349 30 and and CC cord-018437-yjvwa1ot 349 31 SH SH NNP cord-018437-yjvwa1ot 349 32 protein protein NN cord-018437-yjvwa1ot 349 33 ( ( -LRB- cord-018437-yjvwa1ot 349 34 a a DT cord-018437-yjvwa1ot 349 35 small small JJ cord-018437-yjvwa1ot 349 36 hydrophobic hydrophobic JJ cord-018437-yjvwa1ot 349 37 protein protein NN cord-018437-yjvwa1ot 349 38 ) ) -RRB- cord-018437-yjvwa1ot 349 39 . . . cord-018437-yjvwa1ot 350 1 Complete complete JJ cord-018437-yjvwa1ot 350 2 virions virion NNS cord-018437-yjvwa1ot 350 3 are be VBP cord-018437-yjvwa1ot 350 4 pleomorphic pleomorphic JJ cord-018437-yjvwa1ot 350 5 ( ( -LRB- cord-018437-yjvwa1ot 350 6 spherical spherical JJ cord-018437-yjvwa1ot 350 7 to to TO cord-018437-yjvwa1ot 350 8 fi fi NNP cord-018437-yjvwa1ot 350 9 lamentous lamentous NNP cord-018437-yjvwa1ot 350 10 forms form NNS cord-018437-yjvwa1ot 350 11 ) ) -RRB- cord-018437-yjvwa1ot 350 12 . . . cord-018437-yjvwa1ot 351 1 The the DT cord-018437-yjvwa1ot 351 2 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 351 3 diameter diameter NN cord-018437-yjvwa1ot 351 4 , , , cord-018437-yjvwa1ot 351 5 12 12 CD cord-018437-yjvwa1ot 351 6 - - SYM cord-018437-yjvwa1ot 351 7 15 15 CD cord-018437-yjvwa1ot 351 8 nm nm NN cord-018437-yjvwa1ot 351 9 , , , cord-018437-yjvwa1ot 351 10 is be VBZ cord-018437-yjvwa1ot 351 11 smaller small JJR cord-018437-yjvwa1ot 351 12 than than IN cord-018437-yjvwa1ot 351 13 typical typical JJ cord-018437-yjvwa1ot 351 14 for for IN cord-018437-yjvwa1ot 351 15 other other JJ cord-018437-yjvwa1ot 351 16 paramyxoviruses paramyxovirus NNS cord-018437-yjvwa1ot 351 17 ( ( -LRB- cord-018437-yjvwa1ot 351 18 Hall Hall NNP cord-018437-yjvwa1ot 351 19 2001 2001 CD cord-018437-yjvwa1ot 351 20 ) ) -RRB- cord-018437-yjvwa1ot 351 21 . . . cord-018437-yjvwa1ot 352 1 The the DT cord-018437-yjvwa1ot 352 2 hRSV hrsv CD cord-018437-yjvwa1ot 352 3 genome genome NN cord-018437-yjvwa1ot 352 4 is be VBZ cord-018437-yjvwa1ot 352 5 ~15 ~15 JJS cord-018437-yjvwa1ot 352 6 kb kb NNP cord-018437-yjvwa1ot 352 7 and and CC cord-018437-yjvwa1ot 352 8 includes include VBZ cord-018437-yjvwa1ot 352 9 ten ten CD cord-018437-yjvwa1ot 352 10 genes gene NNS cord-018437-yjvwa1ot 352 11 ( ( -LRB- cord-018437-yjvwa1ot 352 12 Collins Collins NNP cord-018437-yjvwa1ot 352 13 and and CC cord-018437-yjvwa1ot 352 14 Wertz Wertz NNP cord-018437-yjvwa1ot 352 15 1983 1983 CD cord-018437-yjvwa1ot 352 16 ) ) -RRB- cord-018437-yjvwa1ot 352 17 . . . cord-018437-yjvwa1ot 353 1 The the DT cord-018437-yjvwa1ot 353 2 fi fi NN cord-018437-yjvwa1ot 353 3 rst rst NN cord-018437-yjvwa1ot 353 4 eight eight CD cord-018437-yjvwa1ot 353 5 reading reading NN cord-018437-yjvwa1ot 353 6 frames frame NNS cord-018437-yjvwa1ot 353 7 are be VBP cord-018437-yjvwa1ot 353 8 nonoverlapping nonoverlappe VBG cord-018437-yjvwa1ot 353 9 ; ; : cord-018437-yjvwa1ot 353 10 the the DT cord-018437-yjvwa1ot 353 11 last last JJ cord-018437-yjvwa1ot 353 12 two two CD cord-018437-yjvwa1ot 353 13 genes gene NNS cord-018437-yjvwa1ot 353 14 , , , cord-018437-yjvwa1ot 353 15 M2 M2 NNP cord-018437-yjvwa1ot 353 16 and and CC cord-018437-yjvwa1ot 353 17 L L NNP cord-018437-yjvwa1ot 353 18 , , , cord-018437-yjvwa1ot 353 19 overlap overlap VBP cord-018437-yjvwa1ot 353 20 by by IN cord-018437-yjvwa1ot 353 21 62 62 CD cord-018437-yjvwa1ot 353 22 nucleotides nucleotide NNS cord-018437-yjvwa1ot 353 23 . . . cord-018437-yjvwa1ot 354 1 In in IN cord-018437-yjvwa1ot 354 2 addition addition NN cord-018437-yjvwa1ot 354 3 to to IN cord-018437-yjvwa1ot 354 4 N N NNP cord-018437-yjvwa1ot 354 5 , , , cord-018437-yjvwa1ot 354 6 P P NNP cord-018437-yjvwa1ot 354 7 , , , cord-018437-yjvwa1ot 354 8 and and CC cord-018437-yjvwa1ot 354 9 L l NN cord-018437-yjvwa1ot 354 10 proteins protein NNS cord-018437-yjvwa1ot 354 11 , , , cord-018437-yjvwa1ot 354 12 M2 M2 NNP cord-018437-yjvwa1ot 354 13 - - SYM cord-018437-yjvwa1ot 354 14 1 1 CD cord-018437-yjvwa1ot 354 15 protein protein NN cord-018437-yjvwa1ot 354 16 , , , cord-018437-yjvwa1ot 354 17 a a DT cord-018437-yjvwa1ot 354 18 transcription transcription NN cord-018437-yjvwa1ot 354 19 factor factor NN cord-018437-yjvwa1ot 354 20 , , , cord-018437-yjvwa1ot 354 21 is be VBZ cord-018437-yjvwa1ot 354 22 associated associate VBN cord-018437-yjvwa1ot 354 23 with with IN cord-018437-yjvwa1ot 354 24 the the DT cord-018437-yjvwa1ot 354 25 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 354 26 . . . cord-018437-yjvwa1ot 355 1 The the DT cord-018437-yjvwa1ot 355 2 overall overall JJ cord-018437-yjvwa1ot 355 3 organization organization NN cord-018437-yjvwa1ot 355 4 of of IN cord-018437-yjvwa1ot 355 5 the the DT cord-018437-yjvwa1ot 355 6 hRSV hRSV NNP cord-018437-yjvwa1ot 355 7 genome genome NNP cord-018437-yjvwa1ot 355 8 is be VBZ cord-018437-yjvwa1ot 355 9 similar similar JJ cord-018437-yjvwa1ot 355 10 to to IN cord-018437-yjvwa1ot 355 11 other other JJ cord-018437-yjvwa1ot 355 12 paramyxoviruses paramyxovirus NNS cord-018437-yjvwa1ot 355 13 . . . cord-018437-yjvwa1ot 356 1 In in IN cord-018437-yjvwa1ot 356 2 addition addition NN cord-018437-yjvwa1ot 356 3 to to IN cord-018437-yjvwa1ot 356 4 the the DT cord-018437-yjvwa1ot 356 5 typical typical JJ cord-018437-yjvwa1ot 356 6 genes gene NNS cord-018437-yjvwa1ot 356 7 , , , cord-018437-yjvwa1ot 356 8 the the DT cord-018437-yjvwa1ot 356 9 hRSV hRSV NNP cord-018437-yjvwa1ot 356 10 genome genome NN cord-018437-yjvwa1ot 356 11 includes include VBZ cord-018437-yjvwa1ot 356 12 genes gene NNS cord-018437-yjvwa1ot 356 13 NS1 NS1 NNS cord-018437-yjvwa1ot 356 14 and and CC cord-018437-yjvwa1ot 356 15 NS2 NS2 NNP cord-018437-yjvwa1ot 356 16 ( ( -LRB- cord-018437-yjvwa1ot 356 17 nonstructural nonstructural JJ cord-018437-yjvwa1ot 356 18 proteins protein NNS cord-018437-yjvwa1ot 356 19 that that WDT cord-018437-yjvwa1ot 356 20 interfere interfere VBP cord-018437-yjvwa1ot 356 21 with with IN cord-018437-yjvwa1ot 356 22 interferon interferon NN cord-018437-yjvwa1ot 356 23 induction induction NN cord-018437-yjvwa1ot 356 24 and and CC cord-018437-yjvwa1ot 356 25 signaling signaling NN cord-018437-yjvwa1ot 356 26 ) ) -RRB- cord-018437-yjvwa1ot 356 27 , , , cord-018437-yjvwa1ot 356 28 SH SH NNP cord-018437-yjvwa1ot 356 29 , , , cord-018437-yjvwa1ot 356 30 and and CC cord-018437-yjvwa1ot 356 31 M2 M2 NNP cord-018437-yjvwa1ot 356 32 - - SYM cord-018437-yjvwa1ot 356 33 1 1 CD cord-018437-yjvwa1ot 356 34 and and CC cord-018437-yjvwa1ot 356 35 M2 M2 NNP cord-018437-yjvwa1ot 356 36 - - HYPH cord-018437-yjvwa1ot 356 37 2 2 NNP cord-018437-yjvwa1ot 356 38 ( ( -LRB- cord-018437-yjvwa1ot 356 39 nonstructural nonstructural JJ cord-018437-yjvwa1ot 356 40 proteins protein NNS cord-018437-yjvwa1ot 356 41 involved involve VBN cord-018437-yjvwa1ot 356 42 in in IN cord-018437-yjvwa1ot 356 43 regulation regulation NN cord-018437-yjvwa1ot 356 44 of of IN cord-018437-yjvwa1ot 356 45 transcription transcription NN cord-018437-yjvwa1ot 356 46 ) ) -RRB- cord-018437-yjvwa1ot 356 47 . . . cord-018437-yjvwa1ot 357 1 There there EX cord-018437-yjvwa1ot 357 2 is be VBZ cord-018437-yjvwa1ot 357 3 no no DT cord-018437-yjvwa1ot 357 4 NH NH NNP cord-018437-yjvwa1ot 357 5 gene gene NN cord-018437-yjvwa1ot 357 6 ; ; : cord-018437-yjvwa1ot 357 7 attachment attachment NN cord-018437-yjvwa1ot 357 8 is be VBZ cord-018437-yjvwa1ot 357 9 mediated mediate VBN cord-018437-yjvwa1ot 357 10 by by IN cord-018437-yjvwa1ot 357 11 the the DT cord-018437-yjvwa1ot 357 12 G g NN cord-018437-yjvwa1ot 357 13 gene gene NN cord-018437-yjvwa1ot 357 14 product product NN cord-018437-yjvwa1ot 357 15 . . . cord-018437-yjvwa1ot 358 1 Human human JJ cord-018437-yjvwa1ot 358 2 respiratory respiratory JJ cord-018437-yjvwa1ot 358 3 syncytial syncytial JJ cord-018437-yjvwa1ot 358 4 virus virus NN cord-018437-yjvwa1ot 358 5 is be VBZ cord-018437-yjvwa1ot 358 6 the the DT cord-018437-yjvwa1ot 358 7 type type NN cord-018437-yjvwa1ot 358 8 species specie NNS cord-018437-yjvwa1ot 358 9 of of IN cord-018437-yjvwa1ot 358 10 the the DT cord-018437-yjvwa1ot 358 11 genus genus NN cord-018437-yjvwa1ot 358 12 Pneumovirus Pneumovirus NNP cord-018437-yjvwa1ot 358 13 in in IN cord-018437-yjvwa1ot 358 14 the the DT cord-018437-yjvwa1ot 358 15 subfamily subfamily NN cord-018437-yjvwa1ot 358 16 Pneumovirinae Pneumovirinae NNP cord-018437-yjvwa1ot 358 17 . . . cord-018437-yjvwa1ot 359 1 There there EX cord-018437-yjvwa1ot 359 2 is be VBZ cord-018437-yjvwa1ot 359 3 a a DT cord-018437-yjvwa1ot 359 4 single single JJ cord-018437-yjvwa1ot 359 5 hRSV hrsv NN cord-018437-yjvwa1ot 359 6 serotype serotype NN cord-018437-yjvwa1ot 359 7 , , , cord-018437-yjvwa1ot 359 8 with with IN cord-018437-yjvwa1ot 359 9 two two CD cord-018437-yjvwa1ot 359 10 antigenic antigenic JJ cord-018437-yjvwa1ot 359 11 subtypes subtype NNS cord-018437-yjvwa1ot 359 12 A A NNP cord-018437-yjvwa1ot 359 13 and and CC cord-018437-yjvwa1ot 359 14 B. B. NNP cord-018437-yjvwa1ot 359 15 ( ( -LRB- cord-018437-yjvwa1ot 359 16 Henrickson Henrickson NNP cord-018437-yjvwa1ot 359 17 2003 2003 CD cord-018437-yjvwa1ot 359 18 ) ) -RRB- cord-018437-yjvwa1ot 359 19 . . . cord-018437-yjvwa1ot 360 1 The the DT cord-018437-yjvwa1ot 360 2 genome genome NN cord-018437-yjvwa1ot 360 3 of of IN cord-018437-yjvwa1ot 360 4 human human JJ cord-018437-yjvwa1ot 360 5 parainfl parainfl NN cord-018437-yjvwa1ot 360 6 uenza uenza NN cord-018437-yjvwa1ot 360 7 viruses virus NNS cord-018437-yjvwa1ot 360 8 is be VBZ cord-018437-yjvwa1ot 360 9 ~15 ~15 $ cord-018437-yjvwa1ot 360 10 kb kb NNP cord-018437-yjvwa1ot 360 11 in in IN cord-018437-yjvwa1ot 360 12 length length NN cord-018437-yjvwa1ot 360 13 with with IN cord-018437-yjvwa1ot 360 14 an an DT cord-018437-yjvwa1ot 360 15 organization organization NN cord-018437-yjvwa1ot 360 16 and and CC cord-018437-yjvwa1ot 360 17 six six CD cord-018437-yjvwa1ot 360 18 reading reading NN cord-018437-yjvwa1ot 360 19 frames frame NNS cord-018437-yjvwa1ot 360 20 ( ( -LRB- cord-018437-yjvwa1ot 360 21 N N NNP cord-018437-yjvwa1ot 360 22 , , , cord-018437-yjvwa1ot 360 23 P P NNP cord-018437-yjvwa1ot 360 24 , , , cord-018437-yjvwa1ot 360 25 M M NNP cord-018437-yjvwa1ot 360 26 , , , cord-018437-yjvwa1ot 360 27 F F NNP cord-018437-yjvwa1ot 360 28 , , , cord-018437-yjvwa1ot 360 29 HN HN NNP cord-018437-yjvwa1ot 360 30 , , , cord-018437-yjvwa1ot 360 31 L L NNP cord-018437-yjvwa1ot 360 32 ) ) -RRB- cord-018437-yjvwa1ot 360 33 typical typical JJ cord-018437-yjvwa1ot 360 34 of of IN cord-018437-yjvwa1ot 360 35 the the DT cord-018437-yjvwa1ot 360 36 Paramyxoviridae Paramyxoviridae NNP cord-018437-yjvwa1ot 361 1 ( ( -LRB- cord-018437-yjvwa1ot 361 2 Karron Karron NNP cord-018437-yjvwa1ot 361 3 and and CC cord-018437-yjvwa1ot 361 4 Collins Collins NNP cord-018437-yjvwa1ot 361 5 2007 2007 CD cord-018437-yjvwa1ot 361 6 ) ) -RRB- cord-018437-yjvwa1ot 361 7 . . . cord-018437-yjvwa1ot 362 1 There there EX cord-018437-yjvwa1ot 362 2 are be VBP cord-018437-yjvwa1ot 362 3 no no DT cord-018437-yjvwa1ot 362 4 overlapping overlap VBG cord-018437-yjvwa1ot 362 5 reading reading NN cord-018437-yjvwa1ot 362 6 frames frame NNS cord-018437-yjvwa1ot 362 7 . . . cord-018437-yjvwa1ot 363 1 Accessory accessory NN cord-018437-yjvwa1ot 363 2 proteins protein NNS cord-018437-yjvwa1ot 363 3 , , , cord-018437-yjvwa1ot 363 4 C C NNP cord-018437-yjvwa1ot 363 5 ( ( -LRB- cord-018437-yjvwa1ot 363 6 HPIV1 HPIV1 NNP cord-018437-yjvwa1ot 363 7 and and CC cord-018437-yjvwa1ot 363 8 3 3 CD cord-018437-yjvwa1ot 363 9 ) ) -RRB- cord-018437-yjvwa1ot 363 10 , , , cord-018437-yjvwa1ot 363 11 V V NNP cord-018437-yjvwa1ot 363 12 ( ( -LRB- cord-018437-yjvwa1ot 363 13 HPIV HPIV NNP cord-018437-yjvwa1ot 363 14 2 2 CD cord-018437-yjvwa1ot 363 15 and and CC cord-018437-yjvwa1ot 363 16 4 4 CD cord-018437-yjvwa1ot 363 17 ) ) -RRB- cord-018437-yjvwa1ot 363 18 , , , cord-018437-yjvwa1ot 363 19 and and CC cord-018437-yjvwa1ot 363 20 D D NNP cord-018437-yjvwa1ot 363 21 ( ( -LRB- cord-018437-yjvwa1ot 363 22 HPIV3 HPIV3 NNP cord-018437-yjvwa1ot 363 23 ) ) -RRB- cord-018437-yjvwa1ot 363 24 , , , cord-018437-yjvwa1ot 363 25 are be VBP cord-018437-yjvwa1ot 363 26 produced produce VBN cord-018437-yjvwa1ot 363 27 by by IN cord-018437-yjvwa1ot 363 28 mRNA mrna NN cord-018437-yjvwa1ot 363 29 editing editing NN cord-018437-yjvwa1ot 363 30 of of IN cord-018437-yjvwa1ot 363 31 the the DT cord-018437-yjvwa1ot 363 32 P p NN cord-018437-yjvwa1ot 363 33 gene gene NN cord-018437-yjvwa1ot 363 34 . . . cord-018437-yjvwa1ot 364 1 N n NN cord-018437-yjvwa1ot 364 2 proteins protein NNS cord-018437-yjvwa1ot 364 3 are be VBP cord-018437-yjvwa1ot 364 4 tightly tightly RB cord-018437-yjvwa1ot 364 5 bound bind VBN cord-018437-yjvwa1ot 364 6 to to IN cord-018437-yjvwa1ot 364 7 viral viral JJ cord-018437-yjvwa1ot 364 8 and and CC cord-018437-yjvwa1ot 364 9 antigenomic antigenomic NNP cord-018437-yjvwa1ot 364 10 RNA RNA NNP cord-018437-yjvwa1ot 364 11 ; ; : cord-018437-yjvwa1ot 364 12 P P NNP cord-018437-yjvwa1ot 364 13 and and CC cord-018437-yjvwa1ot 364 14 L l NN cord-018437-yjvwa1ot 364 15 proteins protein NNS cord-018437-yjvwa1ot 364 16 are be VBP cord-018437-yjvwa1ot 364 17 also also RB cord-018437-yjvwa1ot 364 18 bound bind VBN cord-018437-yjvwa1ot 364 19 to to IN cord-018437-yjvwa1ot 364 20 the the DT cord-018437-yjvwa1ot 364 21 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 364 22 , , , cord-018437-yjvwa1ot 364 23 forming form VBG cord-018437-yjvwa1ot 364 24 functional functional JJ cord-018437-yjvwa1ot 364 25 complexes complex NNS cord-018437-yjvwa1ot 364 26 for for IN cord-018437-yjvwa1ot 364 27 RNA RNA NNP cord-018437-yjvwa1ot 364 28 polymerization polymerization NN cord-018437-yjvwa1ot 364 29 and and CC cord-018437-yjvwa1ot 364 30 processing processing NN cord-018437-yjvwa1ot 364 31 . . . cord-018437-yjvwa1ot 365 1 Human human JJ cord-018437-yjvwa1ot 365 2 parainfl parainfl NN cord-018437-yjvwa1ot 365 3 uenza uenza NN cord-018437-yjvwa1ot 365 4 viruses virus NNS cord-018437-yjvwa1ot 365 5 are be VBP cord-018437-yjvwa1ot 365 6 assigned assign VBN cord-018437-yjvwa1ot 365 7 to to IN cord-018437-yjvwa1ot 365 8 two two CD cord-018437-yjvwa1ot 365 9 genera genus NNS cord-018437-yjvwa1ot 365 10 in in IN cord-018437-yjvwa1ot 365 11 the the DT cord-018437-yjvwa1ot 365 12 subfamily subfamily NN cord-018437-yjvwa1ot 365 13 Paramyxovirinae Paramyxovirinae NNP cord-018437-yjvwa1ot 365 14 . . . cord-018437-yjvwa1ot 366 1 ( ( -LRB- cord-018437-yjvwa1ot 366 2 Berns Berns NNP cord-018437-yjvwa1ot 366 3 1990 1990 CD cord-018437-yjvwa1ot 366 4 ) ) -RRB- cord-018437-yjvwa1ot 366 5 . . . cord-018437-yjvwa1ot 367 1 Virions virion NNS cord-018437-yjvwa1ot 367 2 are be VBP cord-018437-yjvwa1ot 367 3 stable stable JJ cord-018437-yjvwa1ot 367 4 in in IN cord-018437-yjvwa1ot 367 5 the the DT cord-018437-yjvwa1ot 367 6 environment environment NN cord-018437-yjvwa1ot 367 7 and and CC cord-018437-yjvwa1ot 367 8 thought think VBD cord-018437-yjvwa1ot 367 9 to to TO cord-018437-yjvwa1ot 367 10 transmit transmit VB cord-018437-yjvwa1ot 367 11 infection infection NN cord-018437-yjvwa1ot 367 12 by by IN cord-018437-yjvwa1ot 367 13 attachment attachment NN cord-018437-yjvwa1ot 367 14 to to IN cord-018437-yjvwa1ot 367 15 specifi specifi NNP cord-018437-yjvwa1ot 367 16 c c NN cord-018437-yjvwa1ot 367 17 receptors receptor NNS cord-018437-yjvwa1ot 367 18 of of IN cord-018437-yjvwa1ot 367 19 actively actively RB cord-018437-yjvwa1ot 367 20 dividing divide VBG cord-018437-yjvwa1ot 367 21 cells cell NNS cord-018437-yjvwa1ot 367 22 . . . cord-018437-yjvwa1ot 368 1 The the DT cord-018437-yjvwa1ot 368 2 parvovirus parvovirus NN cord-018437-yjvwa1ot 368 3 genome genome NN cord-018437-yjvwa1ot 368 4 is be VBZ cord-018437-yjvwa1ot 368 5 composed compose VBN cord-018437-yjvwa1ot 368 6 of of IN cord-018437-yjvwa1ot 368 7 unsegmented unsegmented JJ cord-018437-yjvwa1ot 368 8 ssDNA ssDNA . cord-018437-yjvwa1ot 369 1 ( ( -LRB- cord-018437-yjvwa1ot 369 2 Cotmore Cotmore NNP cord-018437-yjvwa1ot 369 3 and and CC cord-018437-yjvwa1ot 369 4 Tattersall Tattersall NNP cord-018437-yjvwa1ot 369 5 1984 1984 CD cord-018437-yjvwa1ot 369 6 ; ; : cord-018437-yjvwa1ot 369 7 Shade Shade NNP cord-018437-yjvwa1ot 369 8 et et FW cord-018437-yjvwa1ot 369 9 al al NNP cord-018437-yjvwa1ot 369 10 . . NNP cord-018437-yjvwa1ot 369 11 1986 1986 CD cord-018437-yjvwa1ot 369 12 ; ; . cord-018437-yjvwa1ot 370 1 Zhi Zhi NNP cord-018437-yjvwa1ot 370 2 et et NNP cord-018437-yjvwa1ot 370 3 al al NNP cord-018437-yjvwa1ot 370 4 . . . cord-018437-yjvwa1ot 370 5 2004 2004 CD cord-018437-yjvwa1ot 370 6 ) ) -RRB- cord-018437-yjvwa1ot 370 7 . . . cord-018437-yjvwa1ot 371 1 Complete complete JJ cord-018437-yjvwa1ot 371 2 virions virion NNS cord-018437-yjvwa1ot 371 3 of of IN cord-018437-yjvwa1ot 371 4 different different JJ cord-018437-yjvwa1ot 371 5 species specie NNS cord-018437-yjvwa1ot 371 6 may may MD cord-018437-yjvwa1ot 371 7 contain contain VB cord-018437-yjvwa1ot 371 8 negativesense negativesense NN cord-018437-yjvwa1ot 371 9 or or CC cord-018437-yjvwa1ot 371 10 both both DT cord-018437-yjvwa1ot 371 11 negative negative JJ cord-018437-yjvwa1ot 371 12 - - HYPH cord-018437-yjvwa1ot 371 13 and and CC cord-018437-yjvwa1ot 371 14 positive positive JJ cord-018437-yjvwa1ot 371 15 - - HYPH cord-018437-yjvwa1ot 371 16 sense sense NN cord-018437-yjvwa1ot 371 17 DNA dna NN cord-018437-yjvwa1ot 371 18 in in IN cord-018437-yjvwa1ot 371 19 various various JJ cord-018437-yjvwa1ot 371 20 proportions proportion NNS cord-018437-yjvwa1ot 371 21 . . . cord-018437-yjvwa1ot 372 1 There there EX cord-018437-yjvwa1ot 372 2 are be VBP cord-018437-yjvwa1ot 372 3 two two CD cord-018437-yjvwa1ot 372 4 major major JJ cord-018437-yjvwa1ot 372 5 reading reading NN cord-018437-yjvwa1ot 372 6 frames frame NNS cord-018437-yjvwa1ot 372 7 : : : cord-018437-yjvwa1ot 372 8 one one CD cord-018437-yjvwa1ot 372 9 encoding encode VBG cord-018437-yjvwa1ot 372 10 capsid capsid NN cord-018437-yjvwa1ot 372 11 proteins protein NNS cord-018437-yjvwa1ot 372 12 and and CC cord-018437-yjvwa1ot 372 13 the the DT cord-018437-yjvwa1ot 372 14 other other JJ cord-018437-yjvwa1ot 372 15 coding coding NN cord-018437-yjvwa1ot 372 16 for for IN cord-018437-yjvwa1ot 372 17 nonstructural nonstructural JJ cord-018437-yjvwa1ot 372 18 proteins protein NNS cord-018437-yjvwa1ot 372 19 . . . cord-018437-yjvwa1ot 373 1 Noncoding noncoding NN cord-018437-yjvwa1ot 373 2 sequences sequence NNS cord-018437-yjvwa1ot 373 3 at at IN cord-018437-yjvwa1ot 373 4 the the DT cord-018437-yjvwa1ot 373 5 3′ 3′ CD cord-018437-yjvwa1ot 373 6 and and CC cord-018437-yjvwa1ot 373 7 5′ 5′ NN cord-018437-yjvwa1ot 373 8 ends end NNS cord-018437-yjvwa1ot 373 9 include include VBP cord-018437-yjvwa1ot 373 10 complementary complementary JJ cord-018437-yjvwa1ot 373 11 sequences sequence NNS cord-018437-yjvwa1ot 373 12 which which WDT cord-018437-yjvwa1ot 373 13 result result VBP cord-018437-yjvwa1ot 373 14 in in IN cord-018437-yjvwa1ot 373 15 the the DT cord-018437-yjvwa1ot 373 16 formation formation NN cord-018437-yjvwa1ot 373 17 of of IN cord-018437-yjvwa1ot 373 18 hairpin hairpin JJ cord-018437-yjvwa1ot 373 19 structures structure NNS cord-018437-yjvwa1ot 373 20 that that WDT cord-018437-yjvwa1ot 373 21 serve serve VBP cord-018437-yjvwa1ot 373 22 to to TO cord-018437-yjvwa1ot 373 23 regulate regulate VB cord-018437-yjvwa1ot 373 24 nucleic nucleic JJ cord-018437-yjvwa1ot 373 25 acid acid NN cord-018437-yjvwa1ot 373 26 synthesis synthesis NN cord-018437-yjvwa1ot 373 27 ( ( -LRB- cord-018437-yjvwa1ot 373 28 Deiss Deiss NNP cord-018437-yjvwa1ot 373 29 et et NNP cord-018437-yjvwa1ot 373 30 al al NNP cord-018437-yjvwa1ot 373 31 . . NNP cord-018437-yjvwa1ot 373 32 1990 1990 CD cord-018437-yjvwa1ot 373 33 ) ) -RRB- cord-018437-yjvwa1ot 373 34 . . . cord-018437-yjvwa1ot 374 1 Various various JJ cord-018437-yjvwa1ot 374 2 host host NN cord-018437-yjvwa1ot 374 3 - - HYPH cord-018437-yjvwa1ot 374 4 cell cell NN cord-018437-yjvwa1ot 374 5 molecules molecule NNS cord-018437-yjvwa1ot 374 6 mediate mediate VBP cord-018437-yjvwa1ot 374 7 attachment attachment NN cord-018437-yjvwa1ot 374 8 and and CC cord-018437-yjvwa1ot 374 9 infection infection NN cord-018437-yjvwa1ot 374 10 by by IN cord-018437-yjvwa1ot 374 11 parvoviruses parvovirus NNS cord-018437-yjvwa1ot 374 12 . . . cord-018437-yjvwa1ot 375 1 Erythrocyte Erythrocyte NNP cord-018437-yjvwa1ot 375 2 P p NN cord-018437-yjvwa1ot 375 3 antigen antigen NN cord-018437-yjvwa1ot 375 4 is be VBZ cord-018437-yjvwa1ot 375 5 the the DT cord-018437-yjvwa1ot 375 6 major major JJ cord-018437-yjvwa1ot 375 7 receptor receptor NN cord-018437-yjvwa1ot 375 8 for for IN cord-018437-yjvwa1ot 375 9 Human human JJ cord-018437-yjvwa1ot 375 10 parvovirus parvovirus NN cord-018437-yjvwa1ot 375 11 B19 B19 NNP cord-018437-yjvwa1ot 375 12 . . . cord-018437-yjvwa1ot 376 1 Viruses virus NNS cord-018437-yjvwa1ot 376 2 are be VBP cord-018437-yjvwa1ot 376 3 taken take VBN cord-018437-yjvwa1ot 376 4 up up RP cord-018437-yjvwa1ot 376 5 by by IN cord-018437-yjvwa1ot 376 6 endocytosis endocytosis NN cord-018437-yjvwa1ot 376 7 , , , cord-018437-yjvwa1ot 376 8 followed follow VBN cord-018437-yjvwa1ot 376 9 by by IN cord-018437-yjvwa1ot 376 10 transport transport NN cord-018437-yjvwa1ot 376 11 into into IN cord-018437-yjvwa1ot 376 12 the the DT cord-018437-yjvwa1ot 376 13 host host NN cord-018437-yjvwa1ot 376 14 - - HYPH cord-018437-yjvwa1ot 376 15 cell cell NN cord-018437-yjvwa1ot 376 16 nucleus nucleus NN cord-018437-yjvwa1ot 376 17 . . . cord-018437-yjvwa1ot 377 1 Viral viral JJ cord-018437-yjvwa1ot 377 2 DNA dna NN cord-018437-yjvwa1ot 377 3 replication replication NN cord-018437-yjvwa1ot 377 4 depends depend VBZ cord-018437-yjvwa1ot 377 5 on on IN cord-018437-yjvwa1ot 377 6 host host NN cord-018437-yjvwa1ot 377 7 - - HYPH cord-018437-yjvwa1ot 377 8 cell cell NN cord-018437-yjvwa1ot 377 9 polymerases polymerase NNS cord-018437-yjvwa1ot 377 10 during during IN cord-018437-yjvwa1ot 377 11 the the DT cord-018437-yjvwa1ot 377 12 S S NNP cord-018437-yjvwa1ot 377 13 phase phase NN cord-018437-yjvwa1ot 377 14 of of IN cord-018437-yjvwa1ot 377 15 host host NN cord-018437-yjvwa1ot 377 16 - - HYPH cord-018437-yjvwa1ot 377 17 cell cell NN cord-018437-yjvwa1ot 377 18 replication replication NN cord-018437-yjvwa1ot 377 19 . . . cord-018437-yjvwa1ot 378 1 Human human JJ cord-018437-yjvwa1ot 378 2 infections infection NNS cord-018437-yjvwa1ot 378 3 are be VBP cord-018437-yjvwa1ot 378 4 caused cause VBN cord-018437-yjvwa1ot 378 5 by by IN cord-018437-yjvwa1ot 378 6 parvovirus parvovirus NN cord-018437-yjvwa1ot 378 7 B19 B19 NNP cord-018437-yjvwa1ot 378 8 and and CC cord-018437-yjvwa1ot 378 9 bocavirus bocavirus NNP cord-018437-yjvwa1ot 378 10 ( ( -LRB- cord-018437-yjvwa1ot 378 11 Schildgen Schildgen NNP cord-018437-yjvwa1ot 378 12 et et FW cord-018437-yjvwa1ot 378 13 al al NNP cord-018437-yjvwa1ot 378 14 . . NNP cord-018437-yjvwa1ot 378 15 2008 2008 CD cord-018437-yjvwa1ot 378 16 ; ; : cord-018437-yjvwa1ot 378 17 Vicente Vicente NNP cord-018437-yjvwa1ot 378 18 et et NNP cord-018437-yjvwa1ot 378 19 al al NNP cord-018437-yjvwa1ot 378 20 . . NNP cord-018437-yjvwa1ot 378 21 2007 2007 CD cord-018437-yjvwa1ot 378 22 ) ) -RRB- cord-018437-yjvwa1ot 378 23 . . . cord-018437-yjvwa1ot 379 1 The the DT cord-018437-yjvwa1ot 379 2 family family NN cord-018437-yjvwa1ot 379 3 Parvoviridae Parvoviridae NNP cord-018437-yjvwa1ot 379 4 is be VBZ cord-018437-yjvwa1ot 379 5 not not RB cord-018437-yjvwa1ot 379 6 assigned assign VBN cord-018437-yjvwa1ot 379 7 to to IN cord-018437-yjvwa1ot 379 8 an an DT cord-018437-yjvwa1ot 379 9 order order NN cord-018437-yjvwa1ot 379 10 ; ; : cord-018437-yjvwa1ot 379 11 there there EX cord-018437-yjvwa1ot 379 12 are be VBP cord-018437-yjvwa1ot 379 13 two two CD cord-018437-yjvwa1ot 379 14 subfamilies subfamily NNS cord-018437-yjvwa1ot 379 15 , , , cord-018437-yjvwa1ot 379 16 the the DT cord-018437-yjvwa1ot 379 17 Densovirinae Densovirinae NNP cord-018437-yjvwa1ot 379 18 and and CC cord-018437-yjvwa1ot 379 19 the the DT cord-018437-yjvwa1ot 379 20 Parvoviridae Parvoviridae NNP cord-018437-yjvwa1ot 379 21 . . . cord-018437-yjvwa1ot 380 1 There there EX cord-018437-yjvwa1ot 380 2 are be VBP cord-018437-yjvwa1ot 380 3 fi fi FW cord-018437-yjvwa1ot 380 4 ve ve VBN cord-018437-yjvwa1ot 380 5 genera genus NNS cord-018437-yjvwa1ot 380 6 in in IN cord-018437-yjvwa1ot 380 7 the the DT cord-018437-yjvwa1ot 380 8 subfamily subfamily NN cord-018437-yjvwa1ot 381 1 Parvoviridae Parvoviridae NNP cord-018437-yjvwa1ot 381 2 : : : cord-018437-yjvwa1ot 381 3 Amdovirus Amdovirus NNP cord-018437-yjvwa1ot 381 4 ( ( -LRB- cord-018437-yjvwa1ot 381 5 1 1 CD cord-018437-yjvwa1ot 381 6 species specie NNS cord-018437-yjvwa1ot 381 7 ) ) -RRB- cord-018437-yjvwa1ot 381 8 , , , cord-018437-yjvwa1ot 381 9 Bocavirus Bocavirus NNP cord-018437-yjvwa1ot 381 10 ( ( -LRB- cord-018437-yjvwa1ot 381 11 2 2 CD cord-018437-yjvwa1ot 381 12 species specie NNS cord-018437-yjvwa1ot 381 13 including include VBG cord-018437-yjvwa1ot 381 14 the the DT cord-018437-yjvwa1ot 381 15 type type NN cord-018437-yjvwa1ot 381 16 species specie VBZ cord-018437-yjvwa1ot 381 17 Bovine bovine JJ cord-018437-yjvwa1ot 381 18 parvovirus parvovirus NN cord-018437-yjvwa1ot 381 19 ) ) -RRB- cord-018437-yjvwa1ot 381 20 , , , cord-018437-yjvwa1ot 381 21 Dependovirus Dependovirus NNP cord-018437-yjvwa1ot 381 22 ( ( -LRB- cord-018437-yjvwa1ot 381 23 12 12 CD cord-018437-yjvwa1ot 381 24 species specie NNS cord-018437-yjvwa1ot 381 25 , , , cord-018437-yjvwa1ot 381 26 including include VBG cord-018437-yjvwa1ot 381 27 adenoassociated adenoassociate VBN cord-018437-yjvwa1ot 381 28 viruses virus NNS cord-018437-yjvwa1ot 381 29 ) ) -RRB- cord-018437-yjvwa1ot 381 30 , , , cord-018437-yjvwa1ot 381 31 Erythrovirus Erythrovirus NNP cord-018437-yjvwa1ot 381 32 ( ( -LRB- cord-018437-yjvwa1ot 381 33 4 4 CD cord-018437-yjvwa1ot 381 34 species specie NNS cord-018437-yjvwa1ot 381 35 including include VBG cord-018437-yjvwa1ot 381 36 the the DT cord-018437-yjvwa1ot 381 37 type type NN cord-018437-yjvwa1ot 381 38 species specie NNS cord-018437-yjvwa1ot 381 39 Human human JJ cord-018437-yjvwa1ot 381 40 parvovirus parvovirus NN cord-018437-yjvwa1ot 381 41 B19 B19 NNP cord-018437-yjvwa1ot 381 42 ) ) -RRB- cord-018437-yjvwa1ot 381 43 , , , cord-018437-yjvwa1ot 381 44 and and CC cord-018437-yjvwa1ot 381 45 Parvovirus Parvovirus NNP cord-018437-yjvwa1ot 381 46 ( ( -LRB- cord-018437-yjvwa1ot 381 47 12 12 CD cord-018437-yjvwa1ot 381 48 species specie NNS cord-018437-yjvwa1ot 381 49 ) ) -RRB- cord-018437-yjvwa1ot 381 50 . . . cord-018437-yjvwa1ot 382 1 Picornaviridae Picornaviridae NNP cord-018437-yjvwa1ot 382 2 : : : cord-018437-yjvwa1ot 383 1 Infections infection NNS cord-018437-yjvwa1ot 383 2 of of IN cord-018437-yjvwa1ot 383 3 the the DT cord-018437-yjvwa1ot 383 4 respiratory respiratory JJ cord-018437-yjvwa1ot 383 5 tract tract NN cord-018437-yjvwa1ot 383 6 and and CC cord-018437-yjvwa1ot 383 7 other other JJ cord-018437-yjvwa1ot 383 8 organ organ NN cord-018437-yjvwa1ot 383 9 systems system NNS cord-018437-yjvwa1ot 383 10 by by IN cord-018437-yjvwa1ot 383 11 enteroviruses enteroviruses NNP cord-018437-yjvwa1ot 383 12 and and CC cord-018437-yjvwa1ot 383 13 parechovirus parechovirus NNP cord-018437-yjvwa1ot 383 14 are be VBP cord-018437-yjvwa1ot 383 15 well well RB cord-018437-yjvwa1ot 383 16 described describe VBN cord-018437-yjvwa1ot 383 17 . . . cord-018437-yjvwa1ot 384 1 Enteroviruses Enteroviruses NNP cord-018437-yjvwa1ot 384 2 were be VBD cord-018437-yjvwa1ot 384 3 initially initially RB cord-018437-yjvwa1ot 384 4 classifi classifi NNP cord-018437-yjvwa1ot 384 5 ed ed NN cord-018437-yjvwa1ot 384 6 on on IN cord-018437-yjvwa1ot 384 7 the the DT cord-018437-yjvwa1ot 384 8 basis basis NN cord-018437-yjvwa1ot 384 9 of of IN cord-018437-yjvwa1ot 384 10 clinical clinical JJ cord-018437-yjvwa1ot 384 11 disease disease NN cord-018437-yjvwa1ot 384 12 and and CC cord-018437-yjvwa1ot 384 13 epidemiology epidemiology NN cord-018437-yjvwa1ot 384 14 , , , cord-018437-yjvwa1ot 384 15 suckling suckle VBG cord-018437-yjvwa1ot 384 16 mouse mouse NN cord-018437-yjvwa1ot 384 17 inoculation inoculation NN cord-018437-yjvwa1ot 384 18 , , , cord-018437-yjvwa1ot 384 19 replication replication NN cord-018437-yjvwa1ot 384 20 in in IN cord-018437-yjvwa1ot 384 21 cell cell NN cord-018437-yjvwa1ot 384 22 culture culture NN cord-018437-yjvwa1ot 384 23 , , , cord-018437-yjvwa1ot 384 24 electron electron NN cord-018437-yjvwa1ot 384 25 microscopic microscopic JJ cord-018437-yjvwa1ot 384 26 studies study NNS cord-018437-yjvwa1ot 384 27 , , , cord-018437-yjvwa1ot 384 28 physical physical JJ cord-018437-yjvwa1ot 384 29 properties property NNS cord-018437-yjvwa1ot 384 30 , , , cord-018437-yjvwa1ot 384 31 and and CC cord-018437-yjvwa1ot 384 32 the the DT cord-018437-yjvwa1ot 384 33 vast vast JJ cord-018437-yjvwa1ot 384 34 range range NN cord-018437-yjvwa1ot 384 35 of of IN cord-018437-yjvwa1ot 384 36 specifi specifi NNP cord-018437-yjvwa1ot 384 37 c c NNP cord-018437-yjvwa1ot 384 38 antigenic antigenic JJ cord-018437-yjvwa1ot 384 39 differences difference NNS cord-018437-yjvwa1ot 384 40 . . . cord-018437-yjvwa1ot 385 1 The the DT cord-018437-yjvwa1ot 385 2 major major JJ cord-018437-yjvwa1ot 385 3 subgroups subgroup NNS cord-018437-yjvwa1ot 385 4 were be VBD cord-018437-yjvwa1ot 385 5 poliovirus poliovirus NN cord-018437-yjvwa1ot 385 6 , , , cord-018437-yjvwa1ot 385 7 coxsackievirus coxsackievirus NNP cord-018437-yjvwa1ot 385 8 ( ( -LRB- cord-018437-yjvwa1ot 385 9 A a NN cord-018437-yjvwa1ot 385 10 and and CC cord-018437-yjvwa1ot 385 11 B B NNP cord-018437-yjvwa1ot 385 12 ) ) -RRB- cord-018437-yjvwa1ot 385 13 , , , cord-018437-yjvwa1ot 385 14 and and CC cord-018437-yjvwa1ot 385 15 echovirus echovirus NNP cord-018437-yjvwa1ot 385 16 . . . cord-018437-yjvwa1ot 386 1 A a DT cord-018437-yjvwa1ot 386 2 characteristic characteristic NN cord-018437-yjvwa1ot 386 3 of of IN cord-018437-yjvwa1ot 386 4 these these DT cord-018437-yjvwa1ot 386 5 viruses virus NNS cord-018437-yjvwa1ot 386 6 is be VBZ cord-018437-yjvwa1ot 386 7 their -PRON- PRP$ cord-018437-yjvwa1ot 386 8 relative relative JJ cord-018437-yjvwa1ot 386 9 stability stability NN cord-018437-yjvwa1ot 386 10 in in IN cord-018437-yjvwa1ot 386 11 acidic acidic JJ cord-018437-yjvwa1ot 386 12 media medium NNS cord-018437-yjvwa1ot 386 13 and and CC cord-018437-yjvwa1ot 386 14 nonionic nonionic JJ cord-018437-yjvwa1ot 386 15 detergents detergent NNS cord-018437-yjvwa1ot 386 16 . . . cord-018437-yjvwa1ot 387 1 Translation translation NN cord-018437-yjvwa1ot 387 2 of of IN cord-018437-yjvwa1ot 387 3 the the DT cord-018437-yjvwa1ot 387 4 positive positive JJ cord-018437-yjvwa1ot 387 5 - - HYPH cord-018437-yjvwa1ot 387 6 sense sense NN cord-018437-yjvwa1ot 387 7 ssRNA ssrna NN cord-018437-yjvwa1ot 388 1 genome genome NNP cord-018437-yjvwa1ot 388 2 is be VBZ cord-018437-yjvwa1ot 388 3 regulated regulate VBN cord-018437-yjvwa1ot 388 4 by by IN cord-018437-yjvwa1ot 388 5 a a DT cord-018437-yjvwa1ot 388 6 5′ 5′ CD cord-018437-yjvwa1ot 388 7 non non JJ cord-018437-yjvwa1ot 388 8 - - JJ cord-018437-yjvwa1ot 388 9 translated translate VBN cord-018437-yjvwa1ot 388 10 region region NN cord-018437-yjvwa1ot 388 11 ( ( -LRB- cord-018437-yjvwa1ot 388 12 Lindberg Lindberg NNP cord-018437-yjvwa1ot 388 13 and and CC cord-018437-yjvwa1ot 388 14 Polacek Polacek NNP cord-018437-yjvwa1ot 388 15 2000 2000 CD cord-018437-yjvwa1ot 388 16 ) ) -RRB- cord-018437-yjvwa1ot 388 17 that that WDT cord-018437-yjvwa1ot 388 18 is be VBZ cord-018437-yjvwa1ot 388 19 covalently covalently RB cord-018437-yjvwa1ot 388 20 linked link VBN cord-018437-yjvwa1ot 388 21 to to IN cord-018437-yjvwa1ot 388 22 protein protein NN cord-018437-yjvwa1ot 388 23 VPg VPg NNS cord-018437-yjvwa1ot 388 24 ( ( -LRB- cord-018437-yjvwa1ot 388 25 virion virion NN cord-018437-yjvwa1ot 388 26 protein protein NN cord-018437-yjvwa1ot 388 27 , , , cord-018437-yjvwa1ot 388 28 genome genome NN cord-018437-yjvwa1ot 388 29 linked link VBN cord-018437-yjvwa1ot 388 30 ) ) -RRB- cord-018437-yjvwa1ot 388 31 ; ; : cord-018437-yjvwa1ot 388 32 the the DT cord-018437-yjvwa1ot 388 33 short short JJ cord-018437-yjvwa1ot 388 34 3′ 3′ CD cord-018437-yjvwa1ot 388 35 noncoding noncoding JJ cord-018437-yjvwa1ot 388 36 region region NN cord-018437-yjvwa1ot 388 37 is be VBZ cord-018437-yjvwa1ot 388 38 polyadenylated polyadenylate VBN cord-018437-yjvwa1ot 388 39 . . . cord-018437-yjvwa1ot 389 1 Translation translation NN cord-018437-yjvwa1ot 389 2 results result NNS cord-018437-yjvwa1ot 389 3 in in IN cord-018437-yjvwa1ot 389 4 synthesis synthesis NN cord-018437-yjvwa1ot 389 5 of of IN cord-018437-yjvwa1ot 389 6 a a DT cord-018437-yjvwa1ot 389 7 single single JJ cord-018437-yjvwa1ot 389 8 polyprotein polyprotein NN cord-018437-yjvwa1ot 389 9 , , , cord-018437-yjvwa1ot 389 10 which which WDT cord-018437-yjvwa1ot 389 11 is be VBZ cord-018437-yjvwa1ot 389 12 cleaved cleave VBN cord-018437-yjvwa1ot 389 13 into into IN cord-018437-yjvwa1ot 389 14 functional functional JJ cord-018437-yjvwa1ot 389 15 proteins protein NNS cord-018437-yjvwa1ot 389 16 by by IN cord-018437-yjvwa1ot 389 17 post post JJ cord-018437-yjvwa1ot 389 18 - - JJ cord-018437-yjvwa1ot 389 19 translational translational JJ cord-018437-yjvwa1ot 389 20 processing processing NN cord-018437-yjvwa1ot 389 21 ( ( -LRB- cord-018437-yjvwa1ot 389 22 Nicklin Nicklin NNP cord-018437-yjvwa1ot 389 23 et et NNP cord-018437-yjvwa1ot 389 24 al al NNP cord-018437-yjvwa1ot 389 25 . . NNP cord-018437-yjvwa1ot 389 26 1987 1987 CD cord-018437-yjvwa1ot 389 27 ; ; . cord-018437-yjvwa1ot 390 1 Pallansch Pallansch NNP cord-018437-yjvwa1ot 390 2 and and CC cord-018437-yjvwa1ot 390 3 Roos Roos NNP cord-018437-yjvwa1ot 390 4 2007 2007 CD cord-018437-yjvwa1ot 390 5 ) ) -RRB- cord-018437-yjvwa1ot 390 6 . . . cord-018437-yjvwa1ot 391 1 There there EX cord-018437-yjvwa1ot 391 2 are be VBP cord-018437-yjvwa1ot 391 3 three three CD cord-018437-yjvwa1ot 391 4 functional functional JJ cord-018437-yjvwa1ot 391 5 regions region NNS cord-018437-yjvwa1ot 391 6 delimited delimit VBN cord-018437-yjvwa1ot 391 7 by by IN cord-018437-yjvwa1ot 391 8 ribosomal ribosomal JJ cord-018437-yjvwa1ot 391 9 entry entry NN cord-018437-yjvwa1ot 391 10 sites site NNS cord-018437-yjvwa1ot 391 11 . . . cord-018437-yjvwa1ot 392 1 The the DT cord-018437-yjvwa1ot 392 2 P1 P1 NNP cord-018437-yjvwa1ot 392 3 region region NN cord-018437-yjvwa1ot 392 4 codes code NNS cord-018437-yjvwa1ot 392 5 for for IN cord-018437-yjvwa1ot 392 6 capsid capsid NN cord-018437-yjvwa1ot 392 7 proteins protein NNS cord-018437-yjvwa1ot 392 8 , , , cord-018437-yjvwa1ot 392 9 while while IN cord-018437-yjvwa1ot 392 10 regions region NNS cord-018437-yjvwa1ot 392 11 P2 P2 NNP cord-018437-yjvwa1ot 392 12 and and CC cord-018437-yjvwa1ot 392 13 P3 P3 NNP cord-018437-yjvwa1ot 392 14 code code NN cord-018437-yjvwa1ot 392 15 for for IN cord-018437-yjvwa1ot 392 16 nonstructural nonstructural JJ cord-018437-yjvwa1ot 392 17 proteins protein NNS cord-018437-yjvwa1ot 392 18 . . . cord-018437-yjvwa1ot 393 1 Capsid capsid NN cord-018437-yjvwa1ot 393 2 proteins protein NNS cord-018437-yjvwa1ot 393 3 VP1 vp1 NN cord-018437-yjvwa1ot 393 4 , , , cord-018437-yjvwa1ot 393 5 VP2 vp2 NN cord-018437-yjvwa1ot 393 6 , , , cord-018437-yjvwa1ot 393 7 and and CC cord-018437-yjvwa1ot 393 8 VP3 VP3 NNP cord-018437-yjvwa1ot 393 9 are be VBP cord-018437-yjvwa1ot 393 10 exposed expose VBN cord-018437-yjvwa1ot 393 11 externally externally RB cord-018437-yjvwa1ot 393 12 and and CC cord-018437-yjvwa1ot 393 13 account account VB cord-018437-yjvwa1ot 393 14 for for IN cord-018437-yjvwa1ot 393 15 the the DT cord-018437-yjvwa1ot 393 16 serological serological JJ cord-018437-yjvwa1ot 393 17 diversity diversity NN cord-018437-yjvwa1ot 393 18 of of IN cord-018437-yjvwa1ot 393 19 the the DT cord-018437-yjvwa1ot 393 20 viruses virus NNS cord-018437-yjvwa1ot 393 21 . . . cord-018437-yjvwa1ot 394 1 With with IN cord-018437-yjvwa1ot 394 2 the the DT cord-018437-yjvwa1ot 394 3 advent advent NN cord-018437-yjvwa1ot 394 4 of of IN cord-018437-yjvwa1ot 394 5 molecular molecular JJ cord-018437-yjvwa1ot 394 6 phylogenetic phylogenetic JJ cord-018437-yjvwa1ot 394 7 analysis analysis NN cord-018437-yjvwa1ot 394 8 , , , cord-018437-yjvwa1ot 394 9 the the DT cord-018437-yjvwa1ot 394 10 enteroviruses enterovirus NNS cord-018437-yjvwa1ot 394 11 have have VBP cord-018437-yjvwa1ot 394 12 been be VBN cord-018437-yjvwa1ot 394 13 reclassifi reclassifi VBN cord-018437-yjvwa1ot 394 14 ed ed NN cord-018437-yjvwa1ot 394 15 by by IN cord-018437-yjvwa1ot 394 16 the the DT cord-018437-yjvwa1ot 394 17 ICTV ICTV NNP cord-018437-yjvwa1ot 394 18 . . . cord-018437-yjvwa1ot 395 1 Enteroviruses enterovirus NNS cord-018437-yjvwa1ot 395 2 are be VBP cord-018437-yjvwa1ot 395 3 in in IN cord-018437-yjvwa1ot 395 4 the the DT cord-018437-yjvwa1ot 395 5 order order NN cord-018437-yjvwa1ot 395 6 Picornavirales Picornavirales NNP cord-018437-yjvwa1ot 395 7 , , , cord-018437-yjvwa1ot 395 8 family family NN cord-018437-yjvwa1ot 395 9 Picornaviridae Picornaviridae NNP cord-018437-yjvwa1ot 395 10 , , , cord-018437-yjvwa1ot 395 11 and and CC cord-018437-yjvwa1ot 395 12 genus genus NN cord-018437-yjvwa1ot 395 13 Enterovirus enterovirus NN cord-018437-yjvwa1ot 395 14 . . . cord-018437-yjvwa1ot 396 1 The the DT cord-018437-yjvwa1ot 396 2 enteroviruses enterovirus NNS cord-018437-yjvwa1ot 396 3 have have VBP cord-018437-yjvwa1ot 396 4 been be VBN cord-018437-yjvwa1ot 396 5 assigned assign VBN cord-018437-yjvwa1ot 396 6 to to IN cord-018437-yjvwa1ot 396 7 12 12 CD cord-018437-yjvwa1ot 396 8 species specie NNS cord-018437-yjvwa1ot 396 9 , , , cord-018437-yjvwa1ot 396 10 including include VBG cord-018437-yjvwa1ot 396 11 Human human JJ cord-018437-yjvwa1ot 396 12 enterovirus enterovirus NN cord-018437-yjvwa1ot 396 13 A a NN cord-018437-yjvwa1ot 396 14 ( ( -LRB- cord-018437-yjvwa1ot 396 15 17 17 CD cord-018437-yjvwa1ot 396 16 serotypes serotype NNS cord-018437-yjvwa1ot 396 17 including include VBG cord-018437-yjvwa1ot 396 18 coxsackieviruses coxsackievirus NNS cord-018437-yjvwa1ot 396 19 and and CC cord-018437-yjvwa1ot 396 20 enteroviruses enteroviruses NNP cord-018437-yjvwa1ot 396 21 ) ) -RRB- cord-018437-yjvwa1ot 396 22 , , , cord-018437-yjvwa1ot 396 23 Human human JJ cord-018437-yjvwa1ot 396 24 enterovirus enterovirus NN cord-018437-yjvwa1ot 396 25 B b NN cord-018437-yjvwa1ot 396 26 ( ( -LRB- cord-018437-yjvwa1ot 396 27 56 56 CD cord-018437-yjvwa1ot 396 28 serotypes serotype NNS cord-018437-yjvwa1ot 396 29 , , , cord-018437-yjvwa1ot 396 30 including include VBG cord-018437-yjvwa1ot 396 31 coxsackieviruses coxsackievirus NNS cord-018437-yjvwa1ot 396 32 , , , cord-018437-yjvwa1ot 396 33 echoviruses echovirus NNS cord-018437-yjvwa1ot 396 34 , , , cord-018437-yjvwa1ot 396 35 and and CC cord-018437-yjvwa1ot 396 36 enteroviruses enteroviruses NNP cord-018437-yjvwa1ot 396 37 ) ) -RRB- cord-018437-yjvwa1ot 396 38 , , , cord-018437-yjvwa1ot 396 39 Human Human NNP cord-018437-yjvwa1ot 396 40 enterovirus enterovirus NN cord-018437-yjvwa1ot 396 41 C c NN cord-018437-yjvwa1ot 396 42 ( ( -LRB- cord-018437-yjvwa1ot 396 43 the the DT cord-018437-yjvwa1ot 396 44 type type NN cord-018437-yjvwa1ot 396 45 species species NN cord-018437-yjvwa1ot 396 46 ; ; : cord-018437-yjvwa1ot 396 47 16 16 CD cord-018437-yjvwa1ot 396 48 serotypes serotype NNS cord-018437-yjvwa1ot 396 49 including include VBG cord-018437-yjvwa1ot 396 50 coxsackieviruses coxsackievirus NNS cord-018437-yjvwa1ot 396 51 , , , cord-018437-yjvwa1ot 396 52 all all DT cord-018437-yjvwa1ot 396 53 human human JJ cord-018437-yjvwa1ot 396 54 polioviruses poliovirus NNS cord-018437-yjvwa1ot 396 55 , , , cord-018437-yjvwa1ot 396 56 and and CC cord-018437-yjvwa1ot 396 57 enteroviruses enteroviruses NNP cord-018437-yjvwa1ot 396 58 ) ) -RRB- cord-018437-yjvwa1ot 396 59 , , , cord-018437-yjvwa1ot 396 60 and and CC cord-018437-yjvwa1ot 396 61 Human Human NNP cord-018437-yjvwa1ot 396 62 enterovirus enterovirus NN cord-018437-yjvwa1ot 396 63 D d NN cord-018437-yjvwa1ot 396 64 ( ( -LRB- cord-018437-yjvwa1ot 396 65 3 3 CD cord-018437-yjvwa1ot 396 66 enterovirus enterovirus NN cord-018437-yjvwa1ot 396 67 serotypes serotype NNS cord-018437-yjvwa1ot 396 68 ) ) -RRB- cord-018437-yjvwa1ot 396 69 . . . cord-018437-yjvwa1ot 397 1 In in IN cord-018437-yjvwa1ot 397 2 addition addition NN cord-018437-yjvwa1ot 397 3 to to IN cord-018437-yjvwa1ot 397 4 the the DT cord-018437-yjvwa1ot 397 5 enteroviruses enterovirus NNS cord-018437-yjvwa1ot 397 6 , , , cord-018437-yjvwa1ot 397 7 the the DT cord-018437-yjvwa1ot 397 8 genus genus NN cord-018437-yjvwa1ot 397 9 Enterovirus Enterovirus NNP cord-018437-yjvwa1ot 397 10 also also RB cord-018437-yjvwa1ot 397 11 includes include VBZ cord-018437-yjvwa1ot 397 12 3 3 CD cord-018437-yjvwa1ot 397 13 rhinoviruses rhinovirus NNS cord-018437-yjvwa1ot 397 14 species specie NNS cord-018437-yjvwa1ot 397 15 , , , cord-018437-yjvwa1ot 397 16 Human human JJ cord-018437-yjvwa1ot 397 17 rhinovirus rhinovirus NN cord-018437-yjvwa1ot 397 18 A a NN cord-018437-yjvwa1ot 397 19 , , , cord-018437-yjvwa1ot 397 20 B b NN cord-018437-yjvwa1ot 397 21 , , , cord-018437-yjvwa1ot 397 22 and and CC cord-018437-yjvwa1ot 397 23 C C NNP cord-018437-yjvwa1ot 397 24 , , , cord-018437-yjvwa1ot 397 25 and and CC cord-018437-yjvwa1ot 397 26 more more JJR cord-018437-yjvwa1ot 397 27 than than IN cord-018437-yjvwa1ot 397 28 100 100 CD cord-018437-yjvwa1ot 397 29 serotypes serotype NNS cord-018437-yjvwa1ot 397 30 . . . cord-018437-yjvwa1ot 398 1 Also also RB cord-018437-yjvwa1ot 398 2 within within IN cord-018437-yjvwa1ot 398 3 the the DT cord-018437-yjvwa1ot 398 4 family family NN cord-018437-yjvwa1ot 399 1 Picornaviridae Picornaviridae NNP cord-018437-yjvwa1ot 399 2 is be VBZ cord-018437-yjvwa1ot 399 3 the the DT cord-018437-yjvwa1ot 399 4 genus genus NN cord-018437-yjvwa1ot 399 5 Parechovirus Parechovirus NNP cord-018437-yjvwa1ot 399 6 . . . cord-018437-yjvwa1ot 400 1 Human human JJ cord-018437-yjvwa1ot 400 2 parechovirus parechovirus NNP cord-018437-yjvwa1ot 400 3 is be VBZ cord-018437-yjvwa1ot 400 4 the the DT cord-018437-yjvwa1ot 400 5 type type NN cord-018437-yjvwa1ot 400 6 species specie NNS cord-018437-yjvwa1ot 400 7 for for IN cord-018437-yjvwa1ot 400 8 the the DT cord-018437-yjvwa1ot 400 9 genus genus NN cord-018437-yjvwa1ot 400 10 . . . cord-018437-yjvwa1ot 401 1 There there EX cord-018437-yjvwa1ot 401 2 are be VBP cord-018437-yjvwa1ot 401 3 14 14 CD cord-018437-yjvwa1ot 401 4 parechovirus parechovirus NNP cord-018437-yjvwa1ot 401 5 serotypes serotype NNS cord-018437-yjvwa1ot 401 6 . . . cord-018437-yjvwa1ot 402 1 Polyomaviridae Polyomaviridae NNP cord-018437-yjvwa1ot 402 2 : : : cord-018437-yjvwa1ot 403 1 Polyomaviruses polyomaviruse NNS cord-018437-yjvwa1ot 403 2 may may MD cord-018437-yjvwa1ot 403 3 infect infect VB cord-018437-yjvwa1ot 403 4 a a DT cord-018437-yjvwa1ot 403 5 variety variety NN cord-018437-yjvwa1ot 403 6 of of IN cord-018437-yjvwa1ot 403 7 primate primate JJ cord-018437-yjvwa1ot 403 8 and and CC cord-018437-yjvwa1ot 403 9 non non JJ cord-018437-yjvwa1ot 403 10 - - JJ cord-018437-yjvwa1ot 403 11 primate primate JJ cord-018437-yjvwa1ot 403 12 vertebrate vertebrate JJ cord-018437-yjvwa1ot 403 13 host host NN cord-018437-yjvwa1ot 403 14 species specie NNS cord-018437-yjvwa1ot 403 15 ; ; : cord-018437-yjvwa1ot 403 16 the the DT cord-018437-yjvwa1ot 403 17 oncogenic oncogenic JJ cord-018437-yjvwa1ot 403 18 potential potential NN cord-018437-yjvwa1ot 403 19 of of IN cord-018437-yjvwa1ot 403 20 polyomaviruses polyomaviruse NNS cord-018437-yjvwa1ot 403 21 is be VBZ cord-018437-yjvwa1ot 403 22 well well RB cord-018437-yjvwa1ot 403 23 established establish VBN cord-018437-yjvwa1ot 403 24 ( ( -LRB- cord-018437-yjvwa1ot 403 25 White White NNP cord-018437-yjvwa1ot 403 26 and and CC cord-018437-yjvwa1ot 403 27 Khalili Khalili NNP cord-018437-yjvwa1ot 403 28 2004 2004 CD cord-018437-yjvwa1ot 403 29 ) ) -RRB- cord-018437-yjvwa1ot 403 30 . . . cord-018437-yjvwa1ot 404 1 Sialic sialic NN cord-018437-yjvwa1ot 404 2 acid acid NN cord-018437-yjvwa1ot 404 3 and/or and/or CC cord-018437-yjvwa1ot 404 4 gangliosides ganglioside NNS cord-018437-yjvwa1ot 404 5 on on IN cord-018437-yjvwa1ot 404 6 the the DT cord-018437-yjvwa1ot 404 7 hostcell hostcell NNP cord-018437-yjvwa1ot 404 8 membranes membrane NNS cord-018437-yjvwa1ot 404 9 serve serve VBP cord-018437-yjvwa1ot 404 10 as as IN cord-018437-yjvwa1ot 404 11 receptors receptor NNS cord-018437-yjvwa1ot 404 12 for for IN cord-018437-yjvwa1ot 404 13 attachment attachment NN cord-018437-yjvwa1ot 404 14 of of IN cord-018437-yjvwa1ot 404 15 human human JJ cord-018437-yjvwa1ot 404 16 polyomavirus polyomavirus NNP cord-018437-yjvwa1ot 404 17 . . . cord-018437-yjvwa1ot 405 1 Though though IN cord-018437-yjvwa1ot 405 2 these these DT cord-018437-yjvwa1ot 405 3 molecules molecule NNS cord-018437-yjvwa1ot 405 4 are be VBP cord-018437-yjvwa1ot 405 5 widespread widespread JJ cord-018437-yjvwa1ot 405 6 on on IN cord-018437-yjvwa1ot 405 7 human human JJ cord-018437-yjvwa1ot 405 8 cells cell NNS cord-018437-yjvwa1ot 405 9 , , , cord-018437-yjvwa1ot 405 10 there there EX cord-018437-yjvwa1ot 405 11 is be VBZ cord-018437-yjvwa1ot 405 12 a a DT cord-018437-yjvwa1ot 405 13 restricted restricted JJ cord-018437-yjvwa1ot 405 14 tropism tropism NN cord-018437-yjvwa1ot 405 15 . . . cord-018437-yjvwa1ot 406 1 Respiratory respiratory JJ cord-018437-yjvwa1ot 406 2 epithelial epithelial JJ cord-018437-yjvwa1ot 406 3 cells cell NNS cord-018437-yjvwa1ot 406 4 and and CC cord-018437-yjvwa1ot 406 5 cells cell NNS cord-018437-yjvwa1ot 406 6 of of IN cord-018437-yjvwa1ot 406 7 lymphoid lymphoid JJ cord-018437-yjvwa1ot 406 8 origin origin NN cord-018437-yjvwa1ot 406 9 are be VBP cord-018437-yjvwa1ot 406 10 the the DT cord-018437-yjvwa1ot 406 11 likely likely JJ cord-018437-yjvwa1ot 406 12 targets target NNS cord-018437-yjvwa1ot 406 13 for for IN cord-018437-yjvwa1ot 406 14 initial initial JJ cord-018437-yjvwa1ot 406 15 infection infection NN cord-018437-yjvwa1ot 406 16 , , , cord-018437-yjvwa1ot 406 17 followed follow VBN cord-018437-yjvwa1ot 406 18 by by IN cord-018437-yjvwa1ot 406 19 hematogenous hematogenous NNP cord-018437-yjvwa1ot 406 20 spread spread VBD cord-018437-yjvwa1ot 406 21 to to TO cord-018437-yjvwa1ot 406 22 target target VB cord-018437-yjvwa1ot 406 23 organs organ NNS cord-018437-yjvwa1ot 406 24 . . . cord-018437-yjvwa1ot 407 1 The the DT cord-018437-yjvwa1ot 407 2 virions virion NNS cord-018437-yjvwa1ot 407 3 are be VBP cord-018437-yjvwa1ot 407 4 non non JJ cord-018437-yjvwa1ot 407 5 - - JJ cord-018437-yjvwa1ot 407 6 enveloped enveloped JJ cord-018437-yjvwa1ot 407 7 ; ; : cord-018437-yjvwa1ot 407 8 the the DT cord-018437-yjvwa1ot 407 9 icosahedral icosahedral JJ cord-018437-yjvwa1ot 407 10 capsids capsid NNS cord-018437-yjvwa1ot 407 11 ( ( -LRB- cord-018437-yjvwa1ot 407 12 40 40 CD cord-018437-yjvwa1ot 407 13 - - SYM cord-018437-yjvwa1ot 407 14 45 45 CD cord-018437-yjvwa1ot 407 15 nm nm NN cord-018437-yjvwa1ot 407 16 diameter diameter NN cord-018437-yjvwa1ot 407 17 ) ) -RRB- cord-018437-yjvwa1ot 407 18 are be VBP cord-018437-yjvwa1ot 407 19 composed compose VBN cord-018437-yjvwa1ot 407 20 of of IN cord-018437-yjvwa1ot 407 21 three three CD cord-018437-yjvwa1ot 407 22 proteins protein NNS cord-018437-yjvwa1ot 407 23 ( ( -LRB- cord-018437-yjvwa1ot 407 24 VP1 VP1 NNP cord-018437-yjvwa1ot 407 25 , , , cord-018437-yjvwa1ot 407 26 VP2 vp2 NN cord-018437-yjvwa1ot 407 27 , , , cord-018437-yjvwa1ot 407 28 and and CC cord-018437-yjvwa1ot 407 29 VP3 VP3 NNP cord-018437-yjvwa1ot 407 30 ) ) -RRB- cord-018437-yjvwa1ot 407 31 , , , cord-018437-yjvwa1ot 407 32 which which WDT cord-018437-yjvwa1ot 407 33 enclose enclose VBP cord-018437-yjvwa1ot 407 34 the the DT cord-018437-yjvwa1ot 407 35 circular circular JJ cord-018437-yjvwa1ot 407 36 dsDNA dsdna RB cord-018437-yjvwa1ot 407 37 genome genome NN cord-018437-yjvwa1ot 407 38 ( ( -LRB- cord-018437-yjvwa1ot 407 39 ~5 ~5 NNP cord-018437-yjvwa1ot 407 40 kbp kbp NNP cord-018437-yjvwa1ot 407 41 ) ) -RRB- cord-018437-yjvwa1ot 407 42 . . . cord-018437-yjvwa1ot 408 1 The the DT cord-018437-yjvwa1ot 408 2 genome genome NN cord-018437-yjvwa1ot 408 3 is be VBZ cord-018437-yjvwa1ot 408 4 divided divide VBN cord-018437-yjvwa1ot 408 5 into into IN cord-018437-yjvwa1ot 408 6 three three CD cord-018437-yjvwa1ot 408 7 regions region NNS cord-018437-yjvwa1ot 408 8 . . . cord-018437-yjvwa1ot 409 1 The the DT cord-018437-yjvwa1ot 409 2 early early JJ cord-018437-yjvwa1ot 409 3 region region NN cord-018437-yjvwa1ot 409 4 encodes encode VBZ cord-018437-yjvwa1ot 409 5 for for IN cord-018437-yjvwa1ot 409 6 proteins protein NNS cord-018437-yjvwa1ot 409 7 involved involve VBN cord-018437-yjvwa1ot 409 8 in in IN cord-018437-yjvwa1ot 409 9 viral viral JJ cord-018437-yjvwa1ot 409 10 processes process NNS cord-018437-yjvwa1ot 409 11 that that WDT cord-018437-yjvwa1ot 409 12 occur occur VBP cord-018437-yjvwa1ot 409 13 prior prior RB cord-018437-yjvwa1ot 409 14 to to IN cord-018437-yjvwa1ot 409 15 DNA dna NN cord-018437-yjvwa1ot 409 16 replication replication NN cord-018437-yjvwa1ot 409 17 , , , cord-018437-yjvwa1ot 409 18 including include VBG cord-018437-yjvwa1ot 409 19 T t NN cord-018437-yjvwa1ot 409 20 ( ( -LRB- cord-018437-yjvwa1ot 409 21 tumor tumor NN cord-018437-yjvwa1ot 409 22 ) ) -RRB- cord-018437-yjvwa1ot 409 23 antigens antigen NNS cord-018437-yjvwa1ot 409 24 ( ( -LRB- cord-018437-yjvwa1ot 409 25 Benjamin Benjamin NNP cord-018437-yjvwa1ot 409 26 2001 2001 CD cord-018437-yjvwa1ot 409 27 ) ) -RRB- cord-018437-yjvwa1ot 409 28 . . . cord-018437-yjvwa1ot 410 1 The the DT cord-018437-yjvwa1ot 410 2 late late JJ cord-018437-yjvwa1ot 410 3 region region NN cord-018437-yjvwa1ot 410 4 encodes encode VBZ cord-018437-yjvwa1ot 410 5 for for IN cord-018437-yjvwa1ot 410 6 proteins protein NNS cord-018437-yjvwa1ot 410 7 involved involve VBN cord-018437-yjvwa1ot 410 8 in in IN cord-018437-yjvwa1ot 410 9 processes process NNS cord-018437-yjvwa1ot 410 10 that that WDT cord-018437-yjvwa1ot 410 11 primarily primarily RB cord-018437-yjvwa1ot 410 12 occur occur VBP cord-018437-yjvwa1ot 410 13 after after IN cord-018437-yjvwa1ot 410 14 DNA dna NN cord-018437-yjvwa1ot 410 15 replication replication NN cord-018437-yjvwa1ot 410 16 . . . cord-018437-yjvwa1ot 411 1 The the DT cord-018437-yjvwa1ot 411 2 early early JJ cord-018437-yjvwa1ot 411 3 and and CC cord-018437-yjvwa1ot 411 4 late late JJ cord-018437-yjvwa1ot 411 5 regions region NNS cord-018437-yjvwa1ot 411 6 do do VBP cord-018437-yjvwa1ot 411 7 not not RB cord-018437-yjvwa1ot 411 8 overlap overlap VB cord-018437-yjvwa1ot 411 9 and and CC cord-018437-yjvwa1ot 411 10 are be VBP cord-018437-yjvwa1ot 411 11 transcribed transcribe VBN cord-018437-yjvwa1ot 411 12 from from IN cord-018437-yjvwa1ot 411 13 opposite opposite JJ cord-018437-yjvwa1ot 411 14 strands strand NNS cord-018437-yjvwa1ot 411 15 of of IN cord-018437-yjvwa1ot 411 16 the the DT cord-018437-yjvwa1ot 411 17 viral viral JJ cord-018437-yjvwa1ot 411 18 DNA dna NN cord-018437-yjvwa1ot 411 19 and and CC cord-018437-yjvwa1ot 411 20 in in IN cord-018437-yjvwa1ot 411 21 opposite opposite JJ cord-018437-yjvwa1ot 411 22 directions direction NNS cord-018437-yjvwa1ot 411 23 . . . cord-018437-yjvwa1ot 412 1 A a DT cord-018437-yjvwa1ot 412 2 number number NN cord-018437-yjvwa1ot 412 3 of of IN cord-018437-yjvwa1ot 412 4 viral viral JJ cord-018437-yjvwa1ot 412 5 proteins protein NNS cord-018437-yjvwa1ot 412 6 are be VBP cord-018437-yjvwa1ot 412 7 encoded encode VBN cord-018437-yjvwa1ot 412 8 as as IN cord-018437-yjvwa1ot 412 9 a a DT cord-018437-yjvwa1ot 412 10 result result NN cord-018437-yjvwa1ot 412 11 of of IN cord-018437-yjvwa1ot 412 12 alternative alternative JJ cord-018437-yjvwa1ot 412 13 splicing splicing NN cord-018437-yjvwa1ot 412 14 and and CC cord-018437-yjvwa1ot 412 15 other other JJ cord-018437-yjvwa1ot 412 16 posttranslational posttranslational JJ cord-018437-yjvwa1ot 412 17 modifi modifi JJ cord-018437-yjvwa1ot 412 18 cations cation NNS cord-018437-yjvwa1ot 412 19 of of IN cord-018437-yjvwa1ot 412 20 mRNA mRNA NNP cord-018437-yjvwa1ot 412 21 . . . cord-018437-yjvwa1ot 413 1 Polyomaviruses polyomaviruse NNS cord-018437-yjvwa1ot 413 2 are be VBP cord-018437-yjvwa1ot 413 3 members member NNS cord-018437-yjvwa1ot 413 4 of of IN cord-018437-yjvwa1ot 413 5 the the DT cord-018437-yjvwa1ot 413 6 family family NN cord-018437-yjvwa1ot 413 7 Polyomaviridae Polyomaviridae NNP cord-018437-yjvwa1ot 413 8 , , , cord-018437-yjvwa1ot 413 9 which which WDT cord-018437-yjvwa1ot 413 10 is be VBZ cord-018437-yjvwa1ot 413 11 not not RB cord-018437-yjvwa1ot 413 12 assigned assign VBN cord-018437-yjvwa1ot 413 13 to to IN cord-018437-yjvwa1ot 413 14 an an DT cord-018437-yjvwa1ot 413 15 order order NN cord-018437-yjvwa1ot 413 16 . . . cord-018437-yjvwa1ot 414 1 There there EX cord-018437-yjvwa1ot 414 2 is be VBZ cord-018437-yjvwa1ot 414 3 1 1 CD cord-018437-yjvwa1ot 414 4 genus genus NN cord-018437-yjvwa1ot 414 5 , , , cord-018437-yjvwa1ot 414 6 Polyomavirus Polyomavirus NNP cord-018437-yjvwa1ot 414 7 , , , cord-018437-yjvwa1ot 414 8 and and CC cord-018437-yjvwa1ot 414 9 13 13 CD cord-018437-yjvwa1ot 414 10 species specie NNS cord-018437-yjvwa1ot 414 11 , , , cord-018437-yjvwa1ot 414 12 including include VBG cord-018437-yjvwa1ot 414 13 the the DT cord-018437-yjvwa1ot 414 14 human human JJ cord-018437-yjvwa1ot 414 15 pathogens pathogen NNS cord-018437-yjvwa1ot 414 16 BK BK NNP cord-018437-yjvwa1ot 414 17 polyomavirus polyomavirus NNP cord-018437-yjvwa1ot 414 18 and and CC cord-018437-yjvwa1ot 414 19 JC JC NNP cord-018437-yjvwa1ot 414 20 polyomavirus polyomavirus NNP cord-018437-yjvwa1ot 414 21 and and CC cord-018437-yjvwa1ot 414 22 Simian simian JJ cord-018437-yjvwa1ot 414 23 virus virus NN cord-018437-yjvwa1ot 414 24 40 40 CD cord-018437-yjvwa1ot 414 25 ( ( -LRB- cord-018437-yjvwa1ot 414 26 type type NN cord-018437-yjvwa1ot 414 27 species specie NNS cord-018437-yjvwa1ot 414 28 ) ) -RRB- cord-018437-yjvwa1ot 414 29 . . . cord-018437-yjvwa1ot 415 1 Retroviridae retroviridae NN cord-018437-yjvwa1ot 415 2 : : : cord-018437-yjvwa1ot 416 1 The the DT cord-018437-yjvwa1ot 416 2 retroviruses retrovirus NNS cord-018437-yjvwa1ot 416 3 are be VBP cord-018437-yjvwa1ot 416 4 a a DT cord-018437-yjvwa1ot 416 5 unique unique JJ cord-018437-yjvwa1ot 416 6 group group NN cord-018437-yjvwa1ot 416 7 of of IN cord-018437-yjvwa1ot 416 8 viruses virus NNS cord-018437-yjvwa1ot 416 9 , , , cord-018437-yjvwa1ot 416 10 including include VBG cord-018437-yjvwa1ot 416 11 Human Human NNP cord-018437-yjvwa1ot 416 12 Immunodefi Immunodefi NNP cord-018437-yjvwa1ot 416 13 ciency ciency NN cord-018437-yjvwa1ot 416 14 Virus virus NN cord-018437-yjvwa1ot 416 15 types type NNS cord-018437-yjvwa1ot 416 16 1 1 CD cord-018437-yjvwa1ot 416 17 and and CC cord-018437-yjvwa1ot 416 18 2 2 CD cord-018437-yjvwa1ot 416 19 and and CC cord-018437-yjvwa1ot 416 20 Human Human NNP cord-018437-yjvwa1ot 416 21 T t NN cord-018437-yjvwa1ot 416 22 - - HYPH cord-018437-yjvwa1ot 416 23 cell cell NN cord-018437-yjvwa1ot 416 24 Leukemia Leukemia NNP cord-018437-yjvwa1ot 416 25 Virus Virus NNP cord-018437-yjvwa1ot 416 26 type type NN cord-018437-yjvwa1ot 416 27 1 1 CD cord-018437-yjvwa1ot 416 28 ; ; : cord-018437-yjvwa1ot 416 29 they -PRON- PRP cord-018437-yjvwa1ot 416 30 may may MD cord-018437-yjvwa1ot 416 31 infect infect VB cord-018437-yjvwa1ot 416 32 a a DT cord-018437-yjvwa1ot 416 33 wide wide JJ cord-018437-yjvwa1ot 416 34 range range NN cord-018437-yjvwa1ot 416 35 of of IN cord-018437-yjvwa1ot 416 36 vertebral vertebral JJ cord-018437-yjvwa1ot 416 37 host host NN cord-018437-yjvwa1ot 416 38 species specie NNS cord-018437-yjvwa1ot 416 39 . . . cord-018437-yjvwa1ot 417 1 The the DT cord-018437-yjvwa1ot 417 2 human human JJ cord-018437-yjvwa1ot 417 3 immunodefi immunodefi NNP cord-018437-yjvwa1ot 417 4 ciency ciency NNP cord-018437-yjvwa1ot 417 5 viruses virus NNS cord-018437-yjvwa1ot 417 6 and and CC cord-018437-yjvwa1ot 417 7 human human JJ cord-018437-yjvwa1ot 417 8 T t NN cord-018437-yjvwa1ot 417 9 - - HYPH cord-018437-yjvwa1ot 417 10 cell cell NN cord-018437-yjvwa1ot 417 11 leukemia leukemia NN cord-018437-yjvwa1ot 417 12 virus virus NN cord-018437-yjvwa1ot 417 13 1 1 CD cord-018437-yjvwa1ot 417 14 are be VBP cord-018437-yjvwa1ot 417 15 able able JJ cord-018437-yjvwa1ot 417 16 to to TO cord-018437-yjvwa1ot 417 17 cause cause VB cord-018437-yjvwa1ot 417 18 disease disease NN cord-018437-yjvwa1ot 417 19 in in IN cord-018437-yjvwa1ot 417 20 humans human NNS cord-018437-yjvwa1ot 417 21 . . . cord-018437-yjvwa1ot 418 1 These these DT cord-018437-yjvwa1ot 418 2 RNA RNA NNP cord-018437-yjvwa1ot 418 3 viruses virus NNS cord-018437-yjvwa1ot 418 4 use use VBP cord-018437-yjvwa1ot 418 5 a a DT cord-018437-yjvwa1ot 418 6 unique unique JJ cord-018437-yjvwa1ot 418 7 replication replication NN cord-018437-yjvwa1ot 418 8 cycle cycle NN cord-018437-yjvwa1ot 418 9 that that WDT cord-018437-yjvwa1ot 418 10 uses use VBZ cord-018437-yjvwa1ot 418 11 a a DT cord-018437-yjvwa1ot 418 12 " " `` cord-018437-yjvwa1ot 418 13 reverse reverse NN cord-018437-yjvwa1ot 418 14 fl fl NNP cord-018437-yjvwa1ot 418 15 ow ow NN cord-018437-yjvwa1ot 418 16 " " '' cord-018437-yjvwa1ot 418 17 of of IN cord-018437-yjvwa1ot 418 18 genetic genetic JJ cord-018437-yjvwa1ot 418 19 information information NN cord-018437-yjvwa1ot 418 20 from from IN cord-018437-yjvwa1ot 418 21 RNA RNA NNP cord-018437-yjvwa1ot 418 22 to to IN cord-018437-yjvwa1ot 418 23 DNA dna NN cord-018437-yjvwa1ot 418 24 : : : cord-018437-yjvwa1ot 419 1 viral viral NNP cord-018437-yjvwa1ot 419 2 RNA RNA NNP cord-018437-yjvwa1ot 419 3 is be VBZ cord-018437-yjvwa1ot 419 4 reverse reverse RB cord-018437-yjvwa1ot 419 5 transcribed transcribe VBN cord-018437-yjvwa1ot 419 6 and and CC cord-018437-yjvwa1ot 419 7 converted convert VBN cord-018437-yjvwa1ot 419 8 into into IN cord-018437-yjvwa1ot 419 9 a a DT cord-018437-yjvwa1ot 419 10 dsDNA dsdna JJ cord-018437-yjvwa1ot 419 11 copy copy NN cord-018437-yjvwa1ot 419 12 of of IN cord-018437-yjvwa1ot 419 13 the the DT cord-018437-yjvwa1ot 419 14 viral viral JJ cord-018437-yjvwa1ot 419 15 genome genome NN cord-018437-yjvwa1ot 419 16 which which WDT cord-018437-yjvwa1ot 419 17 is be VBZ cord-018437-yjvwa1ot 419 18 integrated integrate VBN cord-018437-yjvwa1ot 419 19 into into IN cord-018437-yjvwa1ot 419 20 the the DT cord-018437-yjvwa1ot 419 21 host host NN cord-018437-yjvwa1ot 419 22 - - HYPH cord-018437-yjvwa1ot 419 23 cell cell NN cord-018437-yjvwa1ot 419 24 genome genome NN cord-018437-yjvwa1ot 419 25 . . . cord-018437-yjvwa1ot 420 1 Integration integration NN cord-018437-yjvwa1ot 420 2 of of IN cord-018437-yjvwa1ot 420 3 the the DT cord-018437-yjvwa1ot 420 4 proviral proviral JJ cord-018437-yjvwa1ot 420 5 DNA DNA NNP cord-018437-yjvwa1ot 420 6 allows allow VBZ cord-018437-yjvwa1ot 420 7 the the DT cord-018437-yjvwa1ot 420 8 viruses virus NNS cord-018437-yjvwa1ot 420 9 to to TO cord-018437-yjvwa1ot 420 10 establish establish VB cord-018437-yjvwa1ot 420 11 persistent persistent JJ cord-018437-yjvwa1ot 420 12 , , , cord-018437-yjvwa1ot 420 13 presumably presumably RB cord-018437-yjvwa1ot 420 14 lifelong lifelong JJ cord-018437-yjvwa1ot 420 15 , , , cord-018437-yjvwa1ot 420 16 infection infection NN cord-018437-yjvwa1ot 420 17 . . . cord-018437-yjvwa1ot 421 1 Another another DT cord-018437-yjvwa1ot 421 2 consequence consequence NN cord-018437-yjvwa1ot 421 3 of of IN cord-018437-yjvwa1ot 421 4 insertion insertion NN cord-018437-yjvwa1ot 421 5 of of IN cord-018437-yjvwa1ot 421 6 the the DT cord-018437-yjvwa1ot 421 7 viral viral JJ cord-018437-yjvwa1ot 421 8 DNA dna NN cord-018437-yjvwa1ot 421 9 is be VBZ cord-018437-yjvwa1ot 421 10 functional functional JJ cord-018437-yjvwa1ot 421 11 mutation mutation NN cord-018437-yjvwa1ot 421 12 of of IN cord-018437-yjvwa1ot 421 13 the the DT cord-018437-yjvwa1ot 421 14 host host NN cord-018437-yjvwa1ot 421 15 genome genome NN cord-018437-yjvwa1ot 421 16 at at IN cord-018437-yjvwa1ot 421 17 the the DT cord-018437-yjvwa1ot 421 18 site site NN cord-018437-yjvwa1ot 421 19 of of IN cord-018437-yjvwa1ot 421 20 insertion insertion NN cord-018437-yjvwa1ot 421 21 which which WDT cord-018437-yjvwa1ot 421 22 may may MD cord-018437-yjvwa1ot 421 23 alter alter VB cord-018437-yjvwa1ot 421 24 the the DT cord-018437-yjvwa1ot 421 25 host host NN cord-018437-yjvwa1ot 421 26 gene gene NN cord-018437-yjvwa1ot 421 27 or or CC cord-018437-yjvwa1ot 421 28 regulation regulation NN cord-018437-yjvwa1ot 421 29 of of IN cord-018437-yjvwa1ot 421 30 a a DT cord-018437-yjvwa1ot 421 31 gene gene NN cord-018437-yjvwa1ot 421 32 's 's POS cord-018437-yjvwa1ot 421 33 expression expression NN cord-018437-yjvwa1ot 421 34 ; ; : cord-018437-yjvwa1ot 421 35 the the DT cord-018437-yjvwa1ot 421 36 oncogenic oncogenic JJ cord-018437-yjvwa1ot 421 37 potential potential NN cord-018437-yjvwa1ot 421 38 of of IN cord-018437-yjvwa1ot 421 39 retroviral retroviral JJ cord-018437-yjvwa1ot 421 40 infection infection NN cord-018437-yjvwa1ot 421 41 is be VBZ cord-018437-yjvwa1ot 421 42 well well RB cord-018437-yjvwa1ot 421 43 described describe VBN cord-018437-yjvwa1ot 421 44 in in IN cord-018437-yjvwa1ot 421 45 humans human NNS cord-018437-yjvwa1ot 421 46 and and CC cord-018437-yjvwa1ot 421 47 other other JJ cord-018437-yjvwa1ot 421 48 vertebrate vertebrate JJ cord-018437-yjvwa1ot 421 49 host host NN cord-018437-yjvwa1ot 421 50 species specie NNS cord-018437-yjvwa1ot 421 51 . . . cord-018437-yjvwa1ot 422 1 The the DT cord-018437-yjvwa1ot 422 2 electron electron NN cord-018437-yjvwa1ot 422 3 microscopic microscopic JJ cord-018437-yjvwa1ot 422 4 morphology morphology NN cord-018437-yjvwa1ot 422 5 of of IN cord-018437-yjvwa1ot 422 6 retroviruses retrovirus NNS cord-018437-yjvwa1ot 422 7 shows show VBZ cord-018437-yjvwa1ot 422 8 a a DT cord-018437-yjvwa1ot 422 9 dense dense JJ cord-018437-yjvwa1ot 422 10 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 422 11 core core NN cord-018437-yjvwa1ot 422 12 ( ( -LRB- cord-018437-yjvwa1ot 422 13 cylindrical cylindrical JJ cord-018437-yjvwa1ot 422 14 or or CC cord-018437-yjvwa1ot 422 15 cone cone NN cord-018437-yjvwa1ot 422 16 shaped shape VBN cord-018437-yjvwa1ot 422 17 ) ) -RRB- cord-018437-yjvwa1ot 422 18 ( ( -LRB- cord-018437-yjvwa1ot 422 19 Chrystie Chrystie NNP cord-018437-yjvwa1ot 422 20 and and CC cord-018437-yjvwa1ot 422 21 Almeida Almeida NNP cord-018437-yjvwa1ot 422 22 1988 1988 CD cord-018437-yjvwa1ot 422 23 ; ; : cord-018437-yjvwa1ot 422 24 Gelderblom Gelderblom NNP cord-018437-yjvwa1ot 422 25 et et FW cord-018437-yjvwa1ot 422 26 al al NNP cord-018437-yjvwa1ot 422 27 . . NNP cord-018437-yjvwa1ot 422 28 1989 1989 CD cord-018437-yjvwa1ot 422 29 ) ) -RRB- cord-018437-yjvwa1ot 422 30 . . . cord-018437-yjvwa1ot 423 1 Viruses virus NNS cord-018437-yjvwa1ot 423 2 are be VBP cord-018437-yjvwa1ot 423 3 functionally functionally RB cord-018437-yjvwa1ot 423 4 diploid diploid JJ cord-018437-yjvwa1ot 423 5 : : : cord-018437-yjvwa1ot 423 6 the the DT cord-018437-yjvwa1ot 423 7 core core NN cord-018437-yjvwa1ot 423 8 includes include VBZ cord-018437-yjvwa1ot 423 9 two two CD cord-018437-yjvwa1ot 423 10 copies copy NNS cord-018437-yjvwa1ot 423 11 of of IN cord-018437-yjvwa1ot 423 12 the the DT cord-018437-yjvwa1ot 423 13 positive positive JJ cord-018437-yjvwa1ot 423 14 - - HYPH cord-018437-yjvwa1ot 423 15 sense sense NN cord-018437-yjvwa1ot 423 16 ssRNA ssrna NN cord-018437-yjvwa1ot 423 17 genome genome NN cord-018437-yjvwa1ot 423 18 , , , cord-018437-yjvwa1ot 423 19 which which WDT cord-018437-yjvwa1ot 423 20 are be VBP cord-018437-yjvwa1ot 423 21 closely closely RB cord-018437-yjvwa1ot 423 22 complexed complexed JJ cord-018437-yjvwa1ot 423 23 with with IN cord-018437-yjvwa1ot 423 24 viral viral JJ cord-018437-yjvwa1ot 423 25 nucleoproteins nucleoprotein NNS cord-018437-yjvwa1ot 423 26 . . . cord-018437-yjvwa1ot 424 1 The the DT cord-018437-yjvwa1ot 424 2 sequences sequence NNS cord-018437-yjvwa1ot 424 3 of of IN cord-018437-yjvwa1ot 424 4 the the DT cord-018437-yjvwa1ot 424 5 two two CD cord-018437-yjvwa1ot 424 6 ssRNA ssrna NN cord-018437-yjvwa1ot 424 7 molecules molecule NNS cord-018437-yjvwa1ot 424 8 may may MD cord-018437-yjvwa1ot 424 9 differ differ VB cord-018437-yjvwa1ot 424 10 because because IN cord-018437-yjvwa1ot 424 11 of of IN cord-018437-yjvwa1ot 424 12 errors error NNS cord-018437-yjvwa1ot 424 13 in in IN cord-018437-yjvwa1ot 424 14 transcription transcription NN cord-018437-yjvwa1ot 424 15 of of IN cord-018437-yjvwa1ot 424 16 new new JJ cord-018437-yjvwa1ot 424 17 genomic genomic NN cord-018437-yjvwa1ot 424 18 ssRNA ssrna NN cord-018437-yjvwa1ot 424 19 molecules molecule NNS cord-018437-yjvwa1ot 424 20 during during IN cord-018437-yjvwa1ot 424 21 replication replication NN cord-018437-yjvwa1ot 424 22 . . . cord-018437-yjvwa1ot 425 1 The the DT cord-018437-yjvwa1ot 425 2 core core NN cord-018437-yjvwa1ot 425 3 also also RB cord-018437-yjvwa1ot 425 4 includes include VBZ cord-018437-yjvwa1ot 425 5 several several JJ cord-018437-yjvwa1ot 425 6 functional functional JJ cord-018437-yjvwa1ot 425 7 viral viral JJ cord-018437-yjvwa1ot 425 8 proteins protein NNS cord-018437-yjvwa1ot 425 9 , , , cord-018437-yjvwa1ot 425 10 including include VBG cord-018437-yjvwa1ot 425 11 reverse reverse JJ cord-018437-yjvwa1ot 425 12 transcriptase transcriptase NN cord-018437-yjvwa1ot 425 13 , , , cord-018437-yjvwa1ot 425 14 integrase integrase NN cord-018437-yjvwa1ot 425 15 , , , cord-018437-yjvwa1ot 425 16 and and CC cord-018437-yjvwa1ot 425 17 protease protease NN cord-018437-yjvwa1ot 425 18 . . . cord-018437-yjvwa1ot 426 1 The the DT cord-018437-yjvwa1ot 426 2 core core NN cord-018437-yjvwa1ot 426 3 is be VBZ cord-018437-yjvwa1ot 426 4 surrounded surround VBN cord-018437-yjvwa1ot 426 5 by by IN cord-018437-yjvwa1ot 426 6 capsid capsid NN cord-018437-yjvwa1ot 426 7 proteins protein NNS cord-018437-yjvwa1ot 426 8 ; ; : cord-018437-yjvwa1ot 426 9 the the DT cord-018437-yjvwa1ot 426 10 nucleocapsid nucleocapsid NN cord-018437-yjvwa1ot 426 11 is be VBZ cord-018437-yjvwa1ot 426 12 surrounded surround VBN cord-018437-yjvwa1ot 426 13 by by IN cord-018437-yjvwa1ot 426 14 viral viral JJ cord-018437-yjvwa1ot 426 15 matrix matrix NN cord-018437-yjvwa1ot 426 16 protein protein NN cord-018437-yjvwa1ot 426 17 . . . cord-018437-yjvwa1ot 427 1 Complete complete JJ cord-018437-yjvwa1ot 427 2 virions virion NNS cord-018437-yjvwa1ot 427 3 are be VBP cord-018437-yjvwa1ot 427 4 surrounded surround VBN cord-018437-yjvwa1ot 427 5 by by IN cord-018437-yjvwa1ot 427 6 an an DT cord-018437-yjvwa1ot 427 7 envelope envelope NN cord-018437-yjvwa1ot 427 8 derived derive VBN cord-018437-yjvwa1ot 427 9 from from IN cord-018437-yjvwa1ot 427 10 virus virus NN cord-018437-yjvwa1ot 427 11 - - HYPH cord-018437-yjvwa1ot 427 12 modifi modifi JJ cord-018437-yjvwa1ot 427 13 ed ed NN cord-018437-yjvwa1ot 427 14 host host NN cord-018437-yjvwa1ot 427 15 - - HYPH cord-018437-yjvwa1ot 427 16 cell cell NN cord-018437-yjvwa1ot 427 17 cytoplasmic cytoplasmic JJ cord-018437-yjvwa1ot 427 18 membranes membrane NNS cord-018437-yjvwa1ot 427 19 ; ; : cord-018437-yjvwa1ot 427 20 the the DT cord-018437-yjvwa1ot 427 21 envelope envelope NN cord-018437-yjvwa1ot 427 22 is be VBZ cord-018437-yjvwa1ot 427 23 studded stud VBN cord-018437-yjvwa1ot 427 24 by by IN cord-018437-yjvwa1ot 427 25 viral viral JJ cord-018437-yjvwa1ot 427 26 glycoproteins glycoprotein NNS cord-018437-yjvwa1ot 427 27 . . . cord-018437-yjvwa1ot 428 1 The the DT cord-018437-yjvwa1ot 428 2 transmembrane transmembrane NN cord-018437-yjvwa1ot 428 3 protein protein NN cord-018437-yjvwa1ot 428 4 extends extend VBZ cord-018437-yjvwa1ot 428 5 from from IN cord-018437-yjvwa1ot 428 6 the the DT cord-018437-yjvwa1ot 428 7 matrix matrix NN cord-018437-yjvwa1ot 428 8 layer layer NN cord-018437-yjvwa1ot 428 9 through through IN cord-018437-yjvwa1ot 428 10 the the DT cord-018437-yjvwa1ot 428 11 lipid lipid NN cord-018437-yjvwa1ot 428 12 bilayer bilayer NN cord-018437-yjvwa1ot 428 13 to to IN cord-018437-yjvwa1ot 428 14 the the DT cord-018437-yjvwa1ot 428 15 external external JJ cord-018437-yjvwa1ot 428 16 surface surface NN cord-018437-yjvwa1ot 428 17 . . . cord-018437-yjvwa1ot 429 1 The the DT cord-018437-yjvwa1ot 429 2 receptorbinding receptorbinding NN cord-018437-yjvwa1ot 429 3 complex complex NN cord-018437-yjvwa1ot 429 4 is be VBZ cord-018437-yjvwa1ot 429 5 anchored anchor VBN cord-018437-yjvwa1ot 429 6 to to IN cord-018437-yjvwa1ot 429 7 the the DT cord-018437-yjvwa1ot 429 8 external external JJ cord-018437-yjvwa1ot 429 9 portion portion NN cord-018437-yjvwa1ot 429 10 of of IN cord-018437-yjvwa1ot 429 11 the the DT cord-018437-yjvwa1ot 429 12 transmembrane transmembrane NNP cord-018437-yjvwa1ot 429 13 protein protein NN cord-018437-yjvwa1ot 429 14 . . . cord-018437-yjvwa1ot 430 1 Mature mature JJ cord-018437-yjvwa1ot 430 2 virions virion NNS cord-018437-yjvwa1ot 430 3 are be VBP cord-018437-yjvwa1ot 430 4 spherical spherical JJ cord-018437-yjvwa1ot 430 5 ( ( -LRB- cord-018437-yjvwa1ot 430 6 ~100 ~100 NFP cord-018437-yjvwa1ot 430 7 nm nm NNP cord-018437-yjvwa1ot 430 8 diameter diameter NN cord-018437-yjvwa1ot 430 9 ) ) -RRB- cord-018437-yjvwa1ot 430 10 . . . cord-018437-yjvwa1ot 431 1 The the DT cord-018437-yjvwa1ot 431 2 ssRNA ssRNA VBG cord-018437-yjvwa1ot 431 3 genomes genome NNS cord-018437-yjvwa1ot 431 4 of of IN cord-018437-yjvwa1ot 431 5 retroviruses retrovirus NNS cord-018437-yjvwa1ot 431 6 are be VBP cord-018437-yjvwa1ot 431 7 similar similar JJ cord-018437-yjvwa1ot 431 8 to to IN cord-018437-yjvwa1ot 431 9 the the DT cord-018437-yjvwa1ot 431 10 host host NN cord-018437-yjvwa1ot 431 11 - - HYPH cord-018437-yjvwa1ot 431 12 cell cell NN cord-018437-yjvwa1ot 431 13 mRNA mrna NN cord-018437-yjvwa1ot 431 14 . . . cord-018437-yjvwa1ot 432 1 A a DT cord-018437-yjvwa1ot 432 2 repeat repeat NN cord-018437-yjvwa1ot 432 3 sequence sequence NN cord-018437-yjvwa1ot 432 4 is be VBZ cord-018437-yjvwa1ot 432 5 present present JJ cord-018437-yjvwa1ot 432 6 at at IN cord-018437-yjvwa1ot 432 7 both both DT cord-018437-yjvwa1ot 432 8 ends end NNS cord-018437-yjvwa1ot 432 9 of of IN cord-018437-yjvwa1ot 432 10 the the DT cord-018437-yjvwa1ot 432 11 ssRNA ssrna NN cord-018437-yjvwa1ot 432 12 ; ; : cord-018437-yjvwa1ot 432 13 the the DT cord-018437-yjvwa1ot 432 14 5′ 5′ CD cord-018437-yjvwa1ot 432 15 end end NN cord-018437-yjvwa1ot 432 16 is be VBZ cord-018437-yjvwa1ot 432 17 capped cap VBN cord-018437-yjvwa1ot 432 18 and and CC cord-018437-yjvwa1ot 432 19 the the DT cord-018437-yjvwa1ot 432 20 3′ 3′ CD cord-018437-yjvwa1ot 432 21 end end NN cord-018437-yjvwa1ot 432 22 polyadenylated polyadenylate VBN cord-018437-yjvwa1ot 432 23 . . . cord-018437-yjvwa1ot 433 1 The the DT cord-018437-yjvwa1ot 433 2 order order NN cord-018437-yjvwa1ot 433 3 of of IN cord-018437-yjvwa1ot 433 4 sequences sequence NNS cord-018437-yjvwa1ot 433 5 from from IN cord-018437-yjvwa1ot 433 6 the the DT cord-018437-yjvwa1ot 433 7 5′ 5′ CD cord-018437-yjvwa1ot 433 8 end end NN cord-018437-yjvwa1ot 433 9 to to IN cord-018437-yjvwa1ot 433 10 the the DT cord-018437-yjvwa1ot 433 11 3′ 3′ CD cord-018437-yjvwa1ot 433 12 end end NN cord-018437-yjvwa1ot 433 13 is be VBZ cord-018437-yjvwa1ot 433 14 Cap Cap NNP cord-018437-yjvwa1ot 433 15 → → SYM cord-018437-yjvwa1ot 433 16 Repeat repeat NN cord-018437-yjvwa1ot 433 17 sequence sequence NN cord-018437-yjvwa1ot 433 18 → → IN cord-018437-yjvwa1ot 433 19 unique unique JJ cord-018437-yjvwa1ot 433 20 sequence sequence NN cord-018437-yjvwa1ot 433 21 ( ( -LRB- cord-018437-yjvwa1ot 433 22 U5 U5 NNP cord-018437-yjvwa1ot 433 23 ) ) -RRB- cord-018437-yjvwa1ot 434 1 → → IN cord-018437-yjvwa1ot 434 2 the the DT cord-018437-yjvwa1ot 434 3 initiation initiation NN cord-018437-yjvwa1ot 434 4 site site NN cord-018437-yjvwa1ot 434 5 for for IN cord-018437-yjvwa1ot 434 6 initiation initiation NN cord-018437-yjvwa1ot 434 7 of of IN cord-018437-yjvwa1ot 434 8 minus minus JJ cord-018437-yjvwa1ot 434 9 - - HYPH cord-018437-yjvwa1ot 434 10 strand strand NN cord-018437-yjvwa1ot 434 11 DNA dna NN cord-018437-yjvwa1ot 434 12 synthesis synthesis NN cord-018437-yjvwa1ot 434 13 → → IN cord-018437-yjvwa1ot 434 14 gag gag NN cord-018437-yjvwa1ot 434 15 gene gene NN cord-018437-yjvwa1ot 435 1 → → IN cord-018437-yjvwa1ot 435 2 pol pol NN cord-018437-yjvwa1ot 435 3 gene gene NN cord-018437-yjvwa1ot 435 4 → → SYM cord-018437-yjvwa1ot 435 5 env env NN cord-018437-yjvwa1ot 435 6 gene gene NN cord-018437-yjvwa1ot 435 7 → → IN cord-018437-yjvwa1ot 435 8 the the DT cord-018437-yjvwa1ot 435 9 initiation initiation NN cord-018437-yjvwa1ot 435 10 site site NN cord-018437-yjvwa1ot 435 11 for for IN cord-018437-yjvwa1ot 435 12 plus plus JJ cord-018437-yjvwa1ot 435 13 - - HYPH cord-018437-yjvwa1ot 435 14 strand strand NN cord-018437-yjvwa1ot 435 15 DNA dna NN cord-018437-yjvwa1ot 435 16 synthesis synthesis NN cord-018437-yjvwa1ot 435 17 → → IN cord-018437-yjvwa1ot 435 18 a a DT cord-018437-yjvwa1ot 435 19 unique unique JJ cord-018437-yjvwa1ot 435 20 sequence sequence NN cord-018437-yjvwa1ot 435 21 ( ( -LRB- cord-018437-yjvwa1ot 435 22 U3 u3 NN cord-018437-yjvwa1ot 435 23 ) ) -RRB- cord-018437-yjvwa1ot 436 1 → → WDT cord-018437-yjvwa1ot 436 2 Repeat repeat NN cord-018437-yjvwa1ot 436 3 sequence sequence NN cord-018437-yjvwa1ot 436 4 → → IN cord-018437-yjvwa1ot 436 5 poly(A poly(a JJ cord-018437-yjvwa1ot 436 6 ) ) -RRB- cord-018437-yjvwa1ot 436 7 sequence sequence NN cord-018437-yjvwa1ot 436 8 . . . cord-018437-yjvwa1ot 437 1 After after IN cord-018437-yjvwa1ot 437 2 entry entry NN cord-018437-yjvwa1ot 437 3 into into IN cord-018437-yjvwa1ot 437 4 the the DT cord-018437-yjvwa1ot 437 5 cytoplasm cytoplasm NN cord-018437-yjvwa1ot 437 6 of of IN cord-018437-yjvwa1ot 437 7 a a DT cord-018437-yjvwa1ot 437 8 susceptible susceptible JJ cord-018437-yjvwa1ot 437 9 cell cell NN cord-018437-yjvwa1ot 437 10 , , , cord-018437-yjvwa1ot 437 11 double double RB cord-018437-yjvwa1ot 437 12 - - HYPH cord-018437-yjvwa1ot 437 13 stranded strand VBN cord-018437-yjvwa1ot 437 14 DNA dna NN cord-018437-yjvwa1ot 437 15 is be VBZ cord-018437-yjvwa1ot 437 16 synthesized synthesize VBN cord-018437-yjvwa1ot 437 17 by by IN cord-018437-yjvwa1ot 437 18 reverse reverse JJ cord-018437-yjvwa1ot 437 19 transcription transcription NN cord-018437-yjvwa1ot 437 20 of of IN cord-018437-yjvwa1ot 437 21 both both DT cord-018437-yjvwa1ot 437 22 copies copy NNS cord-018437-yjvwa1ot 437 23 of of IN cord-018437-yjvwa1ot 437 24 the the DT cord-018437-yjvwa1ot 437 25 retroviral retroviral NN cord-018437-yjvwa1ot 437 26 ssRNA ssRNA '' cord-018437-yjvwa1ot 437 27 . . . cord-018437-yjvwa1ot 438 1 The the DT cord-018437-yjvwa1ot 438 2 viral viral RB cord-018437-yjvwa1ot 438 3 - - HYPH cord-018437-yjvwa1ot 438 4 encoded encode VBN cord-018437-yjvwa1ot 438 5 DNA dna NN cord-018437-yjvwa1ot 438 6 is be VBZ cord-018437-yjvwa1ot 438 7 transported transport VBN cord-018437-yjvwa1ot 438 8 into into IN cord-018437-yjvwa1ot 438 9 the the DT cord-018437-yjvwa1ot 438 10 nucleus nucleus NN cord-018437-yjvwa1ot 438 11 , , , cord-018437-yjvwa1ot 438 12 after after IN cord-018437-yjvwa1ot 438 13 which which WDT cord-018437-yjvwa1ot 438 14 it -PRON- PRP cord-018437-yjvwa1ot 438 15 is be VBZ cord-018437-yjvwa1ot 438 16 integrated integrate VBN cord-018437-yjvwa1ot 438 17 into into IN cord-018437-yjvwa1ot 438 18 the the DT cord-018437-yjvwa1ot 438 19 host host NN cord-018437-yjvwa1ot 438 20 's 's POS cord-018437-yjvwa1ot 438 21 genomic genomic JJ cord-018437-yjvwa1ot 438 22 DNA dna NN cord-018437-yjvwa1ot 438 23 . . . cord-018437-yjvwa1ot 439 1 The the DT cord-018437-yjvwa1ot 439 2 process process NN cord-018437-yjvwa1ot 439 3 of of IN cord-018437-yjvwa1ot 439 4 forming form VBG cord-018437-yjvwa1ot 439 5 new new JJ cord-018437-yjvwa1ot 439 6 virions virion NNS cord-018437-yjvwa1ot 439 7 is be VBZ cord-018437-yjvwa1ot 439 8 initiated initiate VBN cord-018437-yjvwa1ot 439 9 by by IN cord-018437-yjvwa1ot 439 10 transcription transcription NN cord-018437-yjvwa1ot 439 11 of of IN cord-018437-yjvwa1ot 439 12 the the DT cord-018437-yjvwa1ot 439 13 proviral proviral JJ cord-018437-yjvwa1ot 439 14 DNA DNA NNP cord-018437-yjvwa1ot 439 15 . . . cord-018437-yjvwa1ot 440 1 The the DT cord-018437-yjvwa1ot 440 2 processed process VBN cord-018437-yjvwa1ot 440 3 viral viral JJ cord-018437-yjvwa1ot 440 4 RNA RNA NNP cord-018437-yjvwa1ot 440 5 is be VBZ cord-018437-yjvwa1ot 440 6 exported export VBN cord-018437-yjvwa1ot 440 7 into into IN cord-018437-yjvwa1ot 440 8 the the DT cord-018437-yjvwa1ot 440 9 cytoplasm cytoplasm NN cord-018437-yjvwa1ot 440 10 and and CC cord-018437-yjvwa1ot 440 11 genes gene NNS cord-018437-yjvwa1ot 440 12 for for IN cord-018437-yjvwa1ot 440 13 precursor precursor NN cord-018437-yjvwa1ot 440 14 viral viral JJ cord-018437-yjvwa1ot 440 15 proteins protein NNS cord-018437-yjvwa1ot 440 16 are be VBP cord-018437-yjvwa1ot 440 17 translated translate VBN cord-018437-yjvwa1ot 440 18 . . . cord-018437-yjvwa1ot 441 1 Virions virion NNS cord-018437-yjvwa1ot 441 2 are be VBP cord-018437-yjvwa1ot 441 3 assembled assemble VBN cord-018437-yjvwa1ot 441 4 at at IN cord-018437-yjvwa1ot 441 5 the the DT cord-018437-yjvwa1ot 441 6 cytoplasmic cytoplasmic JJ cord-018437-yjvwa1ot 441 7 membrane membrane NN cord-018437-yjvwa1ot 441 8 and and CC cord-018437-yjvwa1ot 441 9 then then RB cord-018437-yjvwa1ot 441 10 released release VBN cord-018437-yjvwa1ot 441 11 by by IN cord-018437-yjvwa1ot 441 12 budding bud VBG cord-018437-yjvwa1ot 441 13 ; ; : cord-018437-yjvwa1ot 441 14 fi fi NNP cord-018437-yjvwa1ot 441 15 nal nal FW cord-018437-yjvwa1ot 441 16 virion virion NN cord-018437-yjvwa1ot 441 17 maturation maturation NN cord-018437-yjvwa1ot 441 18 occurs occur VBZ cord-018437-yjvwa1ot 441 19 by by IN cord-018437-yjvwa1ot 441 20 extracellular extracellular JJ cord-018437-yjvwa1ot 441 21 processing processing NN cord-018437-yjvwa1ot 441 22 of of IN cord-018437-yjvwa1ot 441 23 viral viral JJ cord-018437-yjvwa1ot 441 24 proteins protein NNS cord-018437-yjvwa1ot 441 25 . . . cord-018437-yjvwa1ot 442 1 A a DT cord-018437-yjvwa1ot 442 2 characteristic characteristic NN cord-018437-yjvwa1ot 442 3 of of IN cord-018437-yjvwa1ot 442 4 retroviruses retrovirus NNS cord-018437-yjvwa1ot 442 5 is be VBZ cord-018437-yjvwa1ot 442 6 the the DT cord-018437-yjvwa1ot 442 7 high high JJ cord-018437-yjvwa1ot 442 8 mutation mutation NN cord-018437-yjvwa1ot 442 9 rate rate NN cord-018437-yjvwa1ot 442 10 and and CC cord-018437-yjvwa1ot 442 11 marked mark VBD cord-018437-yjvwa1ot 442 12 genomic genomic JJ cord-018437-yjvwa1ot 442 13 heterogeneity heterogeneity NN cord-018437-yjvwa1ot 442 14 of of IN cord-018437-yjvwa1ot 442 15 isolates isolate NNS cord-018437-yjvwa1ot 442 16 . . . cord-018437-yjvwa1ot 443 1 The the DT cord-018437-yjvwa1ot 443 2 major major JJ cord-018437-yjvwa1ot 443 3 factors factor NNS cord-018437-yjvwa1ot 443 4 that that WDT cord-018437-yjvwa1ot 443 5 contribute contribute VBP cord-018437-yjvwa1ot 443 6 to to IN cord-018437-yjvwa1ot 443 7 this this DT cord-018437-yjvwa1ot 443 8 phenomenon phenomenon NN cord-018437-yjvwa1ot 443 9 include include VBP cord-018437-yjvwa1ot 443 10 ( ( -LRB- cord-018437-yjvwa1ot 443 11 1 1 LS cord-018437-yjvwa1ot 443 12 ) ) -RRB- cord-018437-yjvwa1ot 443 13 error error NN cord-018437-yjvwa1ot 443 14 - - HYPH cord-018437-yjvwa1ot 443 15 prone prone JJ cord-018437-yjvwa1ot 443 16 reverse reverse NN cord-018437-yjvwa1ot 443 17 transcription transcription NN cord-018437-yjvwa1ot 443 18 , , , cord-018437-yjvwa1ot 443 19 without without IN cord-018437-yjvwa1ot 443 20 proofreading proofread VBG cord-018437-yjvwa1ot 443 21 correction correction NN cord-018437-yjvwa1ot 443 22 , , , cord-018437-yjvwa1ot 443 23 of of IN cord-018437-yjvwa1ot 443 24 the the DT cord-018437-yjvwa1ot 443 25 infecting infect VBG cord-018437-yjvwa1ot 443 26 virus virus NN cord-018437-yjvwa1ot 443 27 genome genome NN cord-018437-yjvwa1ot 443 28 ; ; : cord-018437-yjvwa1ot 443 29 ( ( -LRB- cord-018437-yjvwa1ot 443 30 2 2 LS cord-018437-yjvwa1ot 443 31 ) ) -RRB- cord-018437-yjvwa1ot 443 32 recombination recombination NN cord-018437-yjvwa1ot 443 33 between between IN cord-018437-yjvwa1ot 443 34 the the DT cord-018437-yjvwa1ot 443 35 two two CD cord-018437-yjvwa1ot 443 36 genomic genomic JJ cord-018437-yjvwa1ot 443 37 ssRNA ssrna NN cord-018437-yjvwa1ot 443 38 strands strand NNS cord-018437-yjvwa1ot 443 39 during during IN cord-018437-yjvwa1ot 443 40 reverse reverse JJ cord-018437-yjvwa1ot 443 41 transcription transcription NN cord-018437-yjvwa1ot 443 42 ; ; : cord-018437-yjvwa1ot 443 43 and and CC cord-018437-yjvwa1ot 443 44 ( ( -LRB- cord-018437-yjvwa1ot 443 45 3 3 LS cord-018437-yjvwa1ot 443 46 ) ) -RRB- cord-018437-yjvwa1ot 443 47 the the DT cord-018437-yjvwa1ot 443 48 very very RB cord-018437-yjvwa1ot 443 49 high high JJ cord-018437-yjvwa1ot 443 50 - - HYPH cord-018437-yjvwa1ot 443 51 level level NN cord-018437-yjvwa1ot 443 52 production production NN cord-018437-yjvwa1ot 443 53 of of IN cord-018437-yjvwa1ot 443 54 progeny progeny NN cord-018437-yjvwa1ot 443 55 viruses virus NNS cord-018437-yjvwa1ot 443 56 from from IN cord-018437-yjvwa1ot 443 57 infected infected JJ cord-018437-yjvwa1ot 443 58 cells cell NNS cord-018437-yjvwa1ot 443 59 . . . cord-018437-yjvwa1ot 444 1 Retroviruses retrovirus NNS cord-018437-yjvwa1ot 444 2 are be VBP cord-018437-yjvwa1ot 444 3 not not RB cord-018437-yjvwa1ot 444 4 assigned assign VBN cord-018437-yjvwa1ot 444 5 to to IN cord-018437-yjvwa1ot 444 6 a a DT cord-018437-yjvwa1ot 444 7 taxonomic taxonomic JJ cord-018437-yjvwa1ot 444 8 order order NN cord-018437-yjvwa1ot 444 9 . . . cord-018437-yjvwa1ot 445 1 The the DT cord-018437-yjvwa1ot 445 2 family family NN cord-018437-yjvwa1ot 445 3 Retroviridae Retroviridae NNP cord-018437-yjvwa1ot 445 4 has have VBZ cord-018437-yjvwa1ot 445 5 two two CD cord-018437-yjvwa1ot 445 6 subfamilies subfamily NNS cord-018437-yjvwa1ot 445 7 . . . cord-018437-yjvwa1ot 446 1 The the DT cord-018437-yjvwa1ot 446 2 Orthoretrovirinae Orthoretrovirinae NNP cord-018437-yjvwa1ot 446 3 includes include VBZ cord-018437-yjvwa1ot 446 4 six six CD cord-018437-yjvwa1ot 446 5 genera genus NNS cord-018437-yjvwa1ot 446 6 , , , cord-018437-yjvwa1ot 446 7 including include VBG cord-018437-yjvwa1ot 446 8 Deltaretrovirus Deltaretrovirus NNP cord-018437-yjvwa1ot 446 9 and and CC cord-018437-yjvwa1ot 446 10 Lentivirus Lentivirus NNP cord-018437-yjvwa1ot 446 11 . . . cord-018437-yjvwa1ot 447 1 HTLV-1 HTLV-1 NNP cord-018437-yjvwa1ot 447 2 is be VBZ cord-018437-yjvwa1ot 447 3 assigned assign VBN cord-018437-yjvwa1ot 447 4 the the DT cord-018437-yjvwa1ot 447 5 species specie NNS cord-018437-yjvwa1ot 447 6 name name NN cord-018437-yjvwa1ot 447 7 Primate Primate NNP cord-018437-yjvwa1ot 447 8 T T NNP cord-018437-yjvwa1ot 447 9 - - HYPH cord-018437-yjvwa1ot 447 10 lymphotropic lymphotropic NNP cord-018437-yjvwa1ot 447 11 virus virus NN cord-018437-yjvwa1ot 447 12 1 1 CD cord-018437-yjvwa1ot 447 13 in in IN cord-018437-yjvwa1ot 447 14 the the DT cord-018437-yjvwa1ot 447 15 Deltaretrovirus Deltaretrovirus NNP cord-018437-yjvwa1ot 447 16 genus genus NN cord-018437-yjvwa1ot 447 17 . . . cord-018437-yjvwa1ot 448 1 Human human JJ cord-018437-yjvwa1ot 448 2 immunodefi immunodefi NNP cord-018437-yjvwa1ot 448 3 ciency ciency NNP cord-018437-yjvwa1ot 448 4 virus virus NN cord-018437-yjvwa1ot 448 5 1 1 CD cord-018437-yjvwa1ot 448 6 and and CC cord-018437-yjvwa1ot 448 7 HIV-2 HIV-2 NNP cord-018437-yjvwa1ot 448 8 are be VBP cord-018437-yjvwa1ot 448 9 named name VBN cord-018437-yjvwa1ot 448 10 Human Human NNP cord-018437-yjvwa1ot 448 11 immunodefi immunodefi NNP cord-018437-yjvwa1ot 448 12 ciency ciency NNP cord-018437-yjvwa1ot 448 13 virus virus NN cord-018437-yjvwa1ot 448 14 1 1 CD cord-018437-yjvwa1ot 448 15 ( ( -LRB- cord-018437-yjvwa1ot 448 16 type type NN cord-018437-yjvwa1ot 448 17 species specie NNS cord-018437-yjvwa1ot 448 18 ) ) -RRB- cord-018437-yjvwa1ot 448 19 and and CC cord-018437-yjvwa1ot 448 20 Human Human NNP cord-018437-yjvwa1ot 448 21 immunodefi immunodefi NNP cord-018437-yjvwa1ot 448 22 ciency ciency NNP cord-018437-yjvwa1ot 448 23 virus virus NN cord-018437-yjvwa1ot 448 24 2 2 CD cord-018437-yjvwa1ot 448 25 , , , cord-018437-yjvwa1ot 448 26 respectively respectively RB cord-018437-yjvwa1ot 448 27 , , , cord-018437-yjvwa1ot 448 28 in in IN cord-018437-yjvwa1ot 448 29 the the DT cord-018437-yjvwa1ot 448 30 genus genus NN cord-018437-yjvwa1ot 448 31 Lentivirus Lentivirus NNP cord-018437-yjvwa1ot 448 32 ( ( -LRB- cord-018437-yjvwa1ot 448 33 Clavel Clavel NNP cord-018437-yjvwa1ot 448 34 et et FW cord-018437-yjvwa1ot 448 35 al al NNP cord-018437-yjvwa1ot 448 36 . . NNP cord-018437-yjvwa1ot 448 37 1986b 1986b CD cord-018437-yjvwa1ot 448 38 ) ) -RRB- cord-018437-yjvwa1ot 448 39 . . . cord-018437-yjvwa1ot 449 1 • • NNP cord-018437-yjvwa1ot 450 1 Human Human NNP cord-018437-yjvwa1ot 450 2 Immunodefi Immunodefi NNP cord-018437-yjvwa1ot 450 3 ciency ciency NN cord-018437-yjvwa1ot 450 4 Viruses virus NNS cord-018437-yjvwa1ot 450 5 : : : cord-018437-yjvwa1ot 451 1 The the DT cord-018437-yjvwa1ot 451 2 human human JJ cord-018437-yjvwa1ot 451 3 immunodefi immunodefi NNP cord-018437-yjvwa1ot 451 4 ciency ciency NN cord-018437-yjvwa1ot 451 5 viruses virus NNS cord-018437-yjvwa1ot 451 6 have have VBP cord-018437-yjvwa1ot 451 7 a a DT cord-018437-yjvwa1ot 451 8 conical conical JJ cord-018437-yjvwa1ot 451 9 core core NN cord-018437-yjvwa1ot 451 10 surrounded surround VBN cord-018437-yjvwa1ot 451 11 by by IN cord-018437-yjvwa1ot 451 12 an an DT cord-018437-yjvwa1ot 451 13 envelope envelope NN cord-018437-yjvwa1ot 451 14 derived derive VBN cord-018437-yjvwa1ot 451 15 from from IN cord-018437-yjvwa1ot 451 16 viralmodifi viralmodifi NNP cord-018437-yjvwa1ot 451 17 ed ed NNP cord-018437-yjvwa1ot 451 18 host host NN cord-018437-yjvwa1ot 451 19 - - HYPH cord-018437-yjvwa1ot 451 20 cell cell NN cord-018437-yjvwa1ot 451 21 cytoplasmic cytoplasmic JJ cord-018437-yjvwa1ot 451 22 membrane membrane NN cord-018437-yjvwa1ot 451 23 . . . cord-018437-yjvwa1ot 452 1 Binding binding NN cord-018437-yjvwa1ot 452 2 and and CC cord-018437-yjvwa1ot 452 3 entry entry NN cord-018437-yjvwa1ot 452 4 of of IN cord-018437-yjvwa1ot 452 5 HIV HIV NNP cord-018437-yjvwa1ot 452 6 into into IN cord-018437-yjvwa1ot 452 7 susceptible susceptible JJ cord-018437-yjvwa1ot 452 8 cells cell NNS cord-018437-yjvwa1ot 452 9 requires require VBZ cord-018437-yjvwa1ot 452 10 several several JJ cord-018437-yjvwa1ot 452 11 specifi specifi NNS cord-018437-yjvwa1ot 452 12 c c NN cord-018437-yjvwa1ot 452 13 receptors receptor NNS cord-018437-yjvwa1ot 452 14 : : : cord-018437-yjvwa1ot 452 15 CD4 CD4 NNP cord-018437-yjvwa1ot 452 16 ( ( -LRB- cord-018437-yjvwa1ot 452 17 present present JJ cord-018437-yjvwa1ot 452 18 on on IN cord-018437-yjvwa1ot 452 19 host host NN cord-018437-yjvwa1ot 452 20 helper helper NN cord-018437-yjvwa1ot 452 21 T T NNP cord-018437-yjvwa1ot 452 22 cells cell NNS cord-018437-yjvwa1ot 452 23 , , , cord-018437-yjvwa1ot 452 24 CD4 CD4 NNP cord-018437-yjvwa1ot 452 25 + + CC cord-018437-yjvwa1ot 452 26 macrophages macrophage NNS cord-018437-yjvwa1ot 452 27 , , , cord-018437-yjvwa1ot 452 28 and and CC cord-018437-yjvwa1ot 452 29 some some DT cord-018437-yjvwa1ot 452 30 dendritic dendritic JJ cord-018437-yjvwa1ot 452 31 cells cell NNS cord-018437-yjvwa1ot 452 32 ) ) -RRB- cord-018437-yjvwa1ot 452 33 plus plus CC cord-018437-yjvwa1ot 452 34 chemokine chemokine NN cord-018437-yjvwa1ot 452 35 receptors receptor NNS cord-018437-yjvwa1ot 452 36 , , , cord-018437-yjvwa1ot 452 37 including include VBG cord-018437-yjvwa1ot 452 38 CCR5 CCR5 NNP cord-018437-yjvwa1ot 452 39 and and CC cord-018437-yjvwa1ot 452 40 CXCR4 CXCR4 NNP cord-018437-yjvwa1ot 453 1 ( ( -LRB- cord-018437-yjvwa1ot 453 2 Klatzman Klatzman NNP cord-018437-yjvwa1ot 453 3 et et NNP cord-018437-yjvwa1ot 453 4 al al NNP cord-018437-yjvwa1ot 453 5 . . . cord-018437-yjvwa1ot 454 1 1984 1984 CD cord-018437-yjvwa1ot 454 2 ; ; : cord-018437-yjvwa1ot 454 3 Simmons Simmons NNP cord-018437-yjvwa1ot 454 4 et et NNP cord-018437-yjvwa1ot 454 5 al al NNP cord-018437-yjvwa1ot 454 6 . . NNP cord-018437-yjvwa1ot 454 7 1998 1998 CD cord-018437-yjvwa1ot 454 8 ) ) -RRB- cord-018437-yjvwa1ot 454 9 . . . cord-018437-yjvwa1ot 455 1 The the DT cord-018437-yjvwa1ot 455 2 biological biological JJ cord-018437-yjvwa1ot 455 3 properties property NNS cord-018437-yjvwa1ot 455 4 of of IN cord-018437-yjvwa1ot 455 5 HIV-1 HIV-1 NNP cord-018437-yjvwa1ot 455 6 isolates isolate NNS cord-018437-yjvwa1ot 455 7 depend depend VBP cord-018437-yjvwa1ot 455 8 on on IN cord-018437-yjvwa1ot 455 9 the the DT cord-018437-yjvwa1ot 455 10 chemokine chemokine NN cord-018437-yjvwa1ot 455 11 coreceptor(s coreceptor(s NNP cord-018437-yjvwa1ot 455 12 ) ) -RRB- cord-018437-yjvwa1ot 455 13 used use VBN cord-018437-yjvwa1ot 455 14 by by IN cord-018437-yjvwa1ot 455 15 the the DT cord-018437-yjvwa1ot 455 16 virus virus NN cord-018437-yjvwa1ot 455 17 ( ( -LRB- cord-018437-yjvwa1ot 455 18 Berger Berger NNP cord-018437-yjvwa1ot 455 19 et et NNP cord-018437-yjvwa1ot 455 20 al al NNP cord-018437-yjvwa1ot 455 21 . . NNP cord-018437-yjvwa1ot 455 22 1998 1998 CD cord-018437-yjvwa1ot 455 23 ) ) -RRB- cord-018437-yjvwa1ot 455 24 . . . cord-018437-yjvwa1ot 456 1 Isolates isolate NNS cord-018437-yjvwa1ot 456 2 that that IN cord-018437-yjvwa1ot 456 3 exclusively exclusively RB cord-018437-yjvwa1ot 456 4 use use VBP cord-018437-yjvwa1ot 456 5 CXCR4 cxcr4 NN cord-018437-yjvwa1ot 456 6 are be VBP cord-018437-yjvwa1ot 456 7 T t NN cord-018437-yjvwa1ot 456 8 - - HYPH cord-018437-yjvwa1ot 456 9 cell cell NN cord-018437-yjvwa1ot 456 10 tropic tropic NN cord-018437-yjvwa1ot 456 11 with with IN cord-018437-yjvwa1ot 456 12 rapid rapid JJ cord-018437-yjvwa1ot 456 13 replication replication NN cord-018437-yjvwa1ot 456 14 and and CC cord-018437-yjvwa1ot 456 15 syncytium syncytium NN cord-018437-yjvwa1ot 456 16 formation formation NN cord-018437-yjvwa1ot 456 17 . . . cord-018437-yjvwa1ot 457 1 Isolates isolate NNS cord-018437-yjvwa1ot 457 2 that that WDT cord-018437-yjvwa1ot 457 3 use use VBP cord-018437-yjvwa1ot 457 4 CCR5 CCR5 NNP cord-018437-yjvwa1ot 457 5 exclusively exclusively RB cord-018437-yjvwa1ot 457 6 are be VBP cord-018437-yjvwa1ot 457 7 tropic tropic NN cord-018437-yjvwa1ot 457 8 to to IN cord-018437-yjvwa1ot 457 9 macrophages macrophage NNS cord-018437-yjvwa1ot 457 10 , , , cord-018437-yjvwa1ot 457 11 replicate replicate VB cord-018437-yjvwa1ot 457 12 more more RBR cord-018437-yjvwa1ot 457 13 slowly slowly RB cord-018437-yjvwa1ot 457 14 , , , cord-018437-yjvwa1ot 457 15 and and CC cord-018437-yjvwa1ot 457 16 do do VBP cord-018437-yjvwa1ot 457 17 not not RB cord-018437-yjvwa1ot 457 18 induce induce VB cord-018437-yjvwa1ot 457 19 syncytium syncytium NN cord-018437-yjvwa1ot 457 20 formation formation NN cord-018437-yjvwa1ot 457 21 . . . cord-018437-yjvwa1ot 458 1 Isolates isolate NNS cord-018437-yjvwa1ot 458 2 that that WDT cord-018437-yjvwa1ot 458 3 can can MD cord-018437-yjvwa1ot 458 4 use use VB cord-018437-yjvwa1ot 458 5 either either CC cord-018437-yjvwa1ot 458 6 CXCR4 CXCR4 NNS cord-018437-yjvwa1ot 458 7 or or CC cord-018437-yjvwa1ot 458 8 CCR5 CCR5 NNP cord-018437-yjvwa1ot 458 9 have have VBP cord-018437-yjvwa1ot 458 10 intermediate intermediate JJ cord-018437-yjvwa1ot 458 11 phenotypes phenotype NNS cord-018437-yjvwa1ot 458 12 . . . cord-018437-yjvwa1ot 459 1 The the DT cord-018437-yjvwa1ot 459 2 gag gag NN cord-018437-yjvwa1ot 459 3 , , , cord-018437-yjvwa1ot 459 4 pro pro JJ cord-018437-yjvwa1ot 459 5 , , , cord-018437-yjvwa1ot 459 6 pol pol NN cord-018437-yjvwa1ot 459 7 , , , cord-018437-yjvwa1ot 459 8 and and CC cord-018437-yjvwa1ot 459 9 env env NN cord-018437-yjvwa1ot 459 10 genes gene NNS cord-018437-yjvwa1ot 459 11 are be VBP cord-018437-yjvwa1ot 459 12 translated translate VBN cord-018437-yjvwa1ot 459 13 from from IN cord-018437-yjvwa1ot 459 14 full full JJ cord-018437-yjvwa1ot 459 15 - - HYPH cord-018437-yjvwa1ot 459 16 length length NN cord-018437-yjvwa1ot 459 17 mRNA mrna NN cord-018437-yjvwa1ot 459 18 transcripts transcript NNS cord-018437-yjvwa1ot 459 19 of of IN cord-018437-yjvwa1ot 459 20 the the DT cord-018437-yjvwa1ot 459 21 proviral proviral NNP cord-018437-yjvwa1ot 459 22 genome genome NNP cord-018437-yjvwa1ot 459 23 : : : cord-018437-yjvwa1ot 459 24 gag gag NN cord-018437-yjvwa1ot 459 25 and and CC cord-018437-yjvwa1ot 459 26 env env NN cord-018437-yjvwa1ot 459 27 in in IN cord-018437-yjvwa1ot 459 28 one one CD cord-018437-yjvwa1ot 459 29 reading reading NN cord-018437-yjvwa1ot 459 30 frame frame NN cord-018437-yjvwa1ot 459 31 and and CC cord-018437-yjvwa1ot 459 32 pro pro JJ cord-018437-yjvwa1ot 459 33 and and CC cord-018437-yjvwa1ot 459 34 pol pol NN cord-018437-yjvwa1ot 459 35 from from IN cord-018437-yjvwa1ot 459 36 a a DT cord-018437-yjvwa1ot 459 37 second second JJ cord-018437-yjvwa1ot 459 38 reading reading NN cord-018437-yjvwa1ot 459 39 frame frame NN cord-018437-yjvwa1ot 459 40 . . . cord-018437-yjvwa1ot 460 1 In in IN cord-018437-yjvwa1ot 460 2 addition addition NN cord-018437-yjvwa1ot 460 3 , , , cord-018437-yjvwa1ot 460 4 several several JJ cord-018437-yjvwa1ot 460 5 genes gene NNS cord-018437-yjvwa1ot 460 6 are be VBP cord-018437-yjvwa1ot 460 7 transcribed transcribe VBN cord-018437-yjvwa1ot 460 8 from from IN cord-018437-yjvwa1ot 460 9 overlapping overlap VBG cord-018437-yjvwa1ot 460 10 or or CC cord-018437-yjvwa1ot 460 11 unique unique JJ cord-018437-yjvwa1ot 460 12 reading reading NN cord-018437-yjvwa1ot 460 13 frames frame NNS cord-018437-yjvwa1ot 460 14 , , , cord-018437-yjvwa1ot 460 15 including include VBG cord-018437-yjvwa1ot 460 16 several several JJ cord-018437-yjvwa1ot 460 17 spliced splice VBN cord-018437-yjvwa1ot 460 18 gene gene NN cord-018437-yjvwa1ot 460 19 products product NNS cord-018437-yjvwa1ot 460 20 . . . cord-018437-yjvwa1ot 461 1 Human human JJ cord-018437-yjvwa1ot 461 2 immunodefi immunodefi NNP cord-018437-yjvwa1ot 461 3 ciency ciency NNP cord-018437-yjvwa1ot 461 4 type type NN cord-018437-yjvwa1ot 461 5 1 1 CD cord-018437-yjvwa1ot 461 6 and and CC cord-018437-yjvwa1ot 461 7 2 2 CD cord-018437-yjvwa1ot 461 8 viruses virus NNS cord-018437-yjvwa1ot 461 9 evolved evolve VBN cord-018437-yjvwa1ot 461 10 from from IN cord-018437-yjvwa1ot 461 11 simian simian JJ cord-018437-yjvwa1ot 461 12 viruses virus NNS cord-018437-yjvwa1ot 461 13 ( ( -LRB- cord-018437-yjvwa1ot 461 14 Gao Gao NNP cord-018437-yjvwa1ot 461 15 et et NNP cord-018437-yjvwa1ot 461 16 al al NNP cord-018437-yjvwa1ot 461 17 . . . cord-018437-yjvwa1ot 461 18 1999 1999 CD cord-018437-yjvwa1ot 461 19 ; ; . cord-018437-yjvwa1ot 462 1 Peeters Peeters NNP cord-018437-yjvwa1ot 462 2 et et NNP cord-018437-yjvwa1ot 462 3 al al NNP cord-018437-yjvwa1ot 462 4 . . NNP cord-018437-yjvwa1ot 462 5 1989 1989 CD cord-018437-yjvwa1ot 462 6 ; ; : cord-018437-yjvwa1ot 462 7 Daniel Daniel NNP cord-018437-yjvwa1ot 462 8 et et NNP cord-018437-yjvwa1ot 462 9 al al NNP cord-018437-yjvwa1ot 462 10 . . . cord-018437-yjvwa1ot 462 11 1985 1985 CD cord-018437-yjvwa1ot 463 1 ; ; : cord-018437-yjvwa1ot 463 2 Marx Marx NNP cord-018437-yjvwa1ot 463 3 et et NNP cord-018437-yjvwa1ot 463 4 al al NNP cord-018437-yjvwa1ot 463 5 . . NNP cord-018437-yjvwa1ot 463 6 1991 1991 CD cord-018437-yjvwa1ot 463 7 ) ) -RRB- cord-018437-yjvwa1ot 463 8 . . . cord-018437-yjvwa1ot 464 1 These these DT cord-018437-yjvwa1ot 464 2 viruses virus NNS cord-018437-yjvwa1ot 464 3 may may MD cord-018437-yjvwa1ot 464 4 be be VB cord-018437-yjvwa1ot 464 5 distinguished distinguish VBN cord-018437-yjvwa1ot 464 6 by by IN cord-018437-yjvwa1ot 464 7 a a DT cord-018437-yjvwa1ot 464 8 number number NN cord-018437-yjvwa1ot 464 9 of of IN cord-018437-yjvwa1ot 464 10 characteristics characteristic NNS cord-018437-yjvwa1ot 464 11 , , , cord-018437-yjvwa1ot 464 12 including include VBG cord-018437-yjvwa1ot 464 13 clinical clinical JJ cord-018437-yjvwa1ot 464 14 disease disease NN cord-018437-yjvwa1ot 464 15 , , , cord-018437-yjvwa1ot 464 16 specifi specifi NNP cord-018437-yjvwa1ot 464 17 c c NN cord-018437-yjvwa1ot 464 18 antigens antigen NNS cord-018437-yjvwa1ot 464 19 , , , cord-018437-yjvwa1ot 464 20 and and CC cord-018437-yjvwa1ot 464 21 gene gene NN cord-018437-yjvwa1ot 464 22 sequences sequence NNS cord-018437-yjvwa1ot 464 23 ( ( -LRB- cord-018437-yjvwa1ot 464 24 Clavel Clavel NNP cord-018437-yjvwa1ot 464 25 et et FW cord-018437-yjvwa1ot 464 26 al al NNP cord-018437-yjvwa1ot 464 27 . . NNP cord-018437-yjvwa1ot 464 28 1986a 1986a CD cord-018437-yjvwa1ot 464 29 ) ) -RRB- cord-018437-yjvwa1ot 464 30 . . . cord-018437-yjvwa1ot 465 1 HIV-1 HIV-1 NNP cord-018437-yjvwa1ot 465 2 isolates isolate NNS cord-018437-yjvwa1ot 465 3 may may MD cord-018437-yjvwa1ot 465 4 be be VB cord-018437-yjvwa1ot 465 5 further further RB cord-018437-yjvwa1ot 465 6 characterized characterize VBN cord-018437-yjvwa1ot 465 7 into into IN cord-018437-yjvwa1ot 465 8 genetic genetic JJ cord-018437-yjvwa1ot 465 9 groups group NNS cord-018437-yjvwa1ot 465 10 and and CC cord-018437-yjvwa1ot 465 11 subtypes subtype NNS cord-018437-yjvwa1ot 465 12 or or CC cord-018437-yjvwa1ot 465 13 clades clade NNS cord-018437-yjvwa1ot 465 14 ( ( -LRB- cord-018437-yjvwa1ot 465 15 Wainberg Wainberg NNP cord-018437-yjvwa1ot 465 16 2004 2004 CD cord-018437-yjvwa1ot 465 17 ) ) -RRB- cord-018437-yjvwa1ot 465 18 . . . cord-018437-yjvwa1ot 466 1 Most Most JJS cord-018437-yjvwa1ot 466 2 HIV-1 HIV-1 NNP cord-018437-yjvwa1ot 466 3 isolates isolate NNS cord-018437-yjvwa1ot 466 4 are be VBP cord-018437-yjvwa1ot 466 5 in in IN cord-018437-yjvwa1ot 466 6 the the DT cord-018437-yjvwa1ot 466 7 M M NNP cord-018437-yjvwa1ot 466 8 ( ( -LRB- cord-018437-yjvwa1ot 466 9 main main JJ cord-018437-yjvwa1ot 466 10 ) ) -RRB- cord-018437-yjvwa1ot 466 11 group group NN cord-018437-yjvwa1ot 466 12 , , , cord-018437-yjvwa1ot 466 13 which which WDT cord-018437-yjvwa1ot 466 14 has have VBZ cord-018437-yjvwa1ot 466 15 a a DT cord-018437-yjvwa1ot 466 16 number number NN cord-018437-yjvwa1ot 466 17 of of IN cord-018437-yjvwa1ot 466 18 well well JJ cord-018437-yjvwa1ot 466 19 - - HYPH cord-018437-yjvwa1ot 466 20 defi defi NN cord-018437-yjvwa1ot 466 21 ned ned NNP cord-018437-yjvwa1ot 466 22 subgroups subgroup NNS cord-018437-yjvwa1ot 466 23 and and CC cord-018437-yjvwa1ot 466 24 recombinant recombinant JJ cord-018437-yjvwa1ot 466 25 forms form NNS cord-018437-yjvwa1ot 466 26 with with IN cord-018437-yjvwa1ot 466 27 heterogeneous heterogeneous JJ cord-018437-yjvwa1ot 466 28 global global JJ cord-018437-yjvwa1ot 466 29 distribution distribution NN cord-018437-yjvwa1ot 466 30 ; ; , cord-018437-yjvwa1ot 466 31 clade clade NN cord-018437-yjvwa1ot 466 32 B b NN cord-018437-yjvwa1ot 466 33 viruses virus NNS cord-018437-yjvwa1ot 466 34 are be VBP cord-018437-yjvwa1ot 466 35 the the DT cord-018437-yjvwa1ot 466 36 predominant predominant JJ cord-018437-yjvwa1ot 466 37 isolates isolate NNS cord-018437-yjvwa1ot 466 38 in in IN cord-018437-yjvwa1ot 466 39 North North NNP cord-018437-yjvwa1ot 466 40 America America NNP cord-018437-yjvwa1ot 466 41 and and CC cord-018437-yjvwa1ot 466 42 Europe Europe NNP cord-018437-yjvwa1ot 466 43 ( ( -LRB- cord-018437-yjvwa1ot 466 44 Hemelaar Hemelaar NNP cord-018437-yjvwa1ot 466 45 et et NNP cord-018437-yjvwa1ot 466 46 al al NNP cord-018437-yjvwa1ot 466 47 . . . cord-018437-yjvwa1ot 467 1 2006 2006 CD cord-018437-yjvwa1ot 467 2 ; ; : cord-018437-yjvwa1ot 467 3 Osmanov Osmanov NNP cord-018437-yjvwa1ot 467 4 et et NNP cord-018437-yjvwa1ot 467 5 al al NNP cord-018437-yjvwa1ot 467 6 . . . cord-018437-yjvwa1ot 467 7 2002 2002 CD cord-018437-yjvwa1ot 467 8 ) ) -RRB- cord-018437-yjvwa1ot 467 9 . . . cord-018437-yjvwa1ot 468 1 Group group NN cord-018437-yjvwa1ot 468 2 O o NN cord-018437-yjvwa1ot 468 3 ( ( -LRB- cord-018437-yjvwa1ot 468 4 outlier outlier NN cord-018437-yjvwa1ot 468 5 ) ) -RRB- cord-018437-yjvwa1ot 468 6 strains strain NNS cord-018437-yjvwa1ot 468 7 have have VBP cord-018437-yjvwa1ot 468 8 mainly mainly RB cord-018437-yjvwa1ot 468 9 been be VBN cord-018437-yjvwa1ot 468 10 isolated isolate VBN cord-018437-yjvwa1ot 468 11 or or CC cord-018437-yjvwa1ot 468 12 acquired acquire VBN cord-018437-yjvwa1ot 468 13 in in IN cord-018437-yjvwa1ot 468 14 Western Western NNP cord-018437-yjvwa1ot 468 15 Africa Africa NNP cord-018437-yjvwa1ot 468 16 . . . cord-018437-yjvwa1ot 469 1 Group Group NNP cord-018437-yjvwa1ot 469 2 N n CD cord-018437-yjvwa1ot 469 3 ( ( -LRB- cord-018437-yjvwa1ot 469 4 non non NNP cord-018437-yjvwa1ot 469 5 - - JJ cord-018437-yjvwa1ot 469 6 M m JJ cord-018437-yjvwa1ot 469 7 , , , cord-018437-yjvwa1ot 469 8 non non JJ cord-018437-yjvwa1ot 469 9 - - JJ cord-018437-yjvwa1ot 469 10 O o JJ cord-018437-yjvwa1ot 469 11 ) ) -RRB- cord-018437-yjvwa1ot 469 12 and and CC cord-018437-yjvwa1ot 469 13 recombinant recombinant JJ cord-018437-yjvwa1ot 469 14 forms form NNS cord-018437-yjvwa1ot 469 15 are be VBP cord-018437-yjvwa1ot 469 16 also also RB cord-018437-yjvwa1ot 469 17 most most RBS cord-018437-yjvwa1ot 469 18 commonly commonly RB cord-018437-yjvwa1ot 469 19 isolated isolate VBN cord-018437-yjvwa1ot 469 20 from from IN cord-018437-yjvwa1ot 469 21 Western Western NNP cord-018437-yjvwa1ot 469 22 Africa Africa NNP cord-018437-yjvwa1ot 469 23 . . . cord-018437-yjvwa1ot 470 1 • • NNP cord-018437-yjvwa1ot 471 1 Human Human NNP cord-018437-yjvwa1ot 471 2 T T NNP cord-018437-yjvwa1ot 471 3 - - HYPH cord-018437-yjvwa1ot 471 4 Cell Cell NNP cord-018437-yjvwa1ot 471 5 Leukemia Leukemia NNP cord-018437-yjvwa1ot 471 6 Virus virus NN cord-018437-yjvwa1ot 471 7 Type type NN cord-018437-yjvwa1ot 471 8 1 1 CD cord-018437-yjvwa1ot 471 9 : : : cord-018437-yjvwa1ot 472 1 Mature mature JJ cord-018437-yjvwa1ot 472 2 HTLV HTLV NNP cord-018437-yjvwa1ot 472 3 virions virion NNS cord-018437-yjvwa1ot 472 4 have have VBP cord-018437-yjvwa1ot 472 5 a a DT cord-018437-yjvwa1ot 472 6 spherical spherical JJ cord-018437-yjvwa1ot 472 7 core core NN cord-018437-yjvwa1ot 472 8 , , , cord-018437-yjvwa1ot 472 9 symmetrically symmetrically RB cord-018437-yjvwa1ot 472 10 placed place VBN cord-018437-yjvwa1ot 472 11 within within IN cord-018437-yjvwa1ot 472 12 the the DT cord-018437-yjvwa1ot 472 13 envelope envelope NN cord-018437-yjvwa1ot 472 14 . . . cord-018437-yjvwa1ot 473 1 The the DT cord-018437-yjvwa1ot 473 2 host host NN cord-018437-yjvwa1ot 473 3 - - HYPH cord-018437-yjvwa1ot 473 4 cell cell NN cord-018437-yjvwa1ot 473 5 receptor receptor NN cord-018437-yjvwa1ot 473 6 is be VBZ cord-018437-yjvwa1ot 473 7 GLUT-1 GLUT-1 NNP cord-018437-yjvwa1ot 473 8 , , , cord-018437-yjvwa1ot 473 9 a a DT cord-018437-yjvwa1ot 473 10 surface surface NN cord-018437-yjvwa1ot 473 11 glucose glucose NN cord-018437-yjvwa1ot 473 12 transport transport NN cord-018437-yjvwa1ot 473 13 molecule molecule NN cord-018437-yjvwa1ot 473 14 ( ( -LRB- cord-018437-yjvwa1ot 473 15 Manel Manel NNP cord-018437-yjvwa1ot 473 16 et et NNP cord-018437-yjvwa1ot 473 17 al al NNP cord-018437-yjvwa1ot 473 18 . . NNP cord-018437-yjvwa1ot 473 19 2003 2003 CD cord-018437-yjvwa1ot 473 20 ) ) -RRB- cord-018437-yjvwa1ot 473 21 . . . cord-018437-yjvwa1ot 474 1 The the DT cord-018437-yjvwa1ot 474 2 gag gag NN cord-018437-yjvwa1ot 474 3 , , , cord-018437-yjvwa1ot 474 4 pro pro JJ cord-018437-yjvwa1ot 474 5 , , , cord-018437-yjvwa1ot 474 6 pol pol NN cord-018437-yjvwa1ot 474 7 , , , cord-018437-yjvwa1ot 474 8 and and CC cord-018437-yjvwa1ot 474 9 env env NN cord-018437-yjvwa1ot 474 10 genes gene NNS cord-018437-yjvwa1ot 474 11 are be VBP cord-018437-yjvwa1ot 474 12 translated translate VBN cord-018437-yjvwa1ot 474 13 from from IN cord-018437-yjvwa1ot 474 14 fulllength fulllength NN cord-018437-yjvwa1ot 474 15 mRNA mRNA NNP cord-018437-yjvwa1ot 474 16 transcripts transcript NNS cord-018437-yjvwa1ot 474 17 of of IN cord-018437-yjvwa1ot 474 18 the the DT cord-018437-yjvwa1ot 474 19 proviral proviral NNP cord-018437-yjvwa1ot 474 20 genome genome NNP cord-018437-yjvwa1ot 474 21 : : : cord-018437-yjvwa1ot 474 22 gag gag NN cord-018437-yjvwa1ot 474 23 in in IN cord-018437-yjvwa1ot 474 24 one one CD cord-018437-yjvwa1ot 474 25 reading reading NN cord-018437-yjvwa1ot 474 26 frame frame NN cord-018437-yjvwa1ot 474 27 , , , cord-018437-yjvwa1ot 474 28 pro pro JJ cord-018437-yjvwa1ot 474 29 and and CC cord-018437-yjvwa1ot 474 30 env env NN cord-018437-yjvwa1ot 474 31 from from IN cord-018437-yjvwa1ot 474 32 a a DT cord-018437-yjvwa1ot 474 33 second second JJ cord-018437-yjvwa1ot 474 34 , , , cord-018437-yjvwa1ot 474 35 and and CC cord-018437-yjvwa1ot 474 36 pol pol NN cord-018437-yjvwa1ot 474 37 from from IN cord-018437-yjvwa1ot 474 38 a a DT cord-018437-yjvwa1ot 474 39 third third JJ cord-018437-yjvwa1ot 474 40 reading reading NN cord-018437-yjvwa1ot 474 41 frame frame NN cord-018437-yjvwa1ot 474 42 . . . cord-018437-yjvwa1ot 475 1 In in IN cord-018437-yjvwa1ot 475 2 addition addition NN cord-018437-yjvwa1ot 475 3 , , , cord-018437-yjvwa1ot 475 4 several several JJ cord-018437-yjvwa1ot 475 5 spliced splice VBN cord-018437-yjvwa1ot 475 6 genes gene NNS cord-018437-yjvwa1ot 475 7 are be VBP cord-018437-yjvwa1ot 475 8 transcribed transcribe VBN cord-018437-yjvwa1ot 475 9 from from IN cord-018437-yjvwa1ot 475 10 overlapping overlap VBG cord-018437-yjvwa1ot 475 11 reading reading NN cord-018437-yjvwa1ot 475 12 frames frame NNS cord-018437-yjvwa1ot 475 13 . . . cord-018437-yjvwa1ot 476 1 Recent recent JJ cord-018437-yjvwa1ot 476 2 and and CC cord-018437-yjvwa1ot 476 3 continuing continue VBG cord-018437-yjvwa1ot 476 4 progress progress NN cord-018437-yjvwa1ot 476 5 to to TO cord-018437-yjvwa1ot 476 6 develop develop VB cord-018437-yjvwa1ot 476 7 and and CC cord-018437-yjvwa1ot 476 8 use use VB cord-018437-yjvwa1ot 476 9 standardized standardized JJ cord-018437-yjvwa1ot 476 10 and and CC cord-018437-yjvwa1ot 476 11 widely widely RB cord-018437-yjvwa1ot 476 12 accepted accept VBN cord-018437-yjvwa1ot 476 13 methods method NNS cord-018437-yjvwa1ot 476 14 for for IN cord-018437-yjvwa1ot 476 15 biological biological JJ cord-018437-yjvwa1ot 476 16 and and CC cord-018437-yjvwa1ot 476 17 taxonomic taxonomic JJ cord-018437-yjvwa1ot 476 18 classifi classifi NN cord-018437-yjvwa1ot 476 19 cation cation NN cord-018437-yjvwa1ot 476 20 of of IN cord-018437-yjvwa1ot 476 21 viral viral JJ cord-018437-yjvwa1ot 476 22 pathogens pathogen NNS cord-018437-yjvwa1ot 476 23 has have VBZ cord-018437-yjvwa1ot 476 24 resulted result VBN cord-018437-yjvwa1ot 476 25 in in IN cord-018437-yjvwa1ot 476 26 improvement improvement NN cord-018437-yjvwa1ot 476 27 in in IN cord-018437-yjvwa1ot 476 28 the the DT cord-018437-yjvwa1ot 476 29 medical medical JJ cord-018437-yjvwa1ot 476 30 response response NN cord-018437-yjvwa1ot 476 31 to to IN cord-018437-yjvwa1ot 476 32 viral viral JJ cord-018437-yjvwa1ot 476 33 illnesses illness NNS cord-018437-yjvwa1ot 476 34 . . . cord-018437-yjvwa1ot 477 1 At at IN cord-018437-yjvwa1ot 477 2 a a DT cord-018437-yjvwa1ot 477 3 very very RB cord-018437-yjvwa1ot 477 4 basic basic JJ cord-018437-yjvwa1ot 477 5 level level NN cord-018437-yjvwa1ot 477 6 , , , cord-018437-yjvwa1ot 477 7 these these DT cord-018437-yjvwa1ot 477 8 systems system NNS cord-018437-yjvwa1ot 477 9 allow allow VBP cord-018437-yjvwa1ot 477 10 clinicians clinician NNS cord-018437-yjvwa1ot 477 11 and and CC cord-018437-yjvwa1ot 477 12 scientists scientist NNS cord-018437-yjvwa1ot 477 13 to to TO cord-018437-yjvwa1ot 477 14 communicate communicate VB cord-018437-yjvwa1ot 477 15 effectively effectively RB cord-018437-yjvwa1ot 477 16 and and CC cord-018437-yjvwa1ot 477 17 ensure ensure VB cord-018437-yjvwa1ot 477 18 the the DT cord-018437-yjvwa1ot 477 19 comparability comparability NN cord-018437-yjvwa1ot 477 20 of of IN cord-018437-yjvwa1ot 477 21 data datum NNS cord-018437-yjvwa1ot 477 22 generated generate VBN cord-018437-yjvwa1ot 477 23 by by IN cord-018437-yjvwa1ot 477 24 clinical clinical JJ cord-018437-yjvwa1ot 477 25 or or CC cord-018437-yjvwa1ot 477 26 basic basic JJ cord-018437-yjvwa1ot 477 27 scientifi scientifi NN cord-018437-yjvwa1ot 477 28 c c NN cord-018437-yjvwa1ot 477 29 studies study NNS cord-018437-yjvwa1ot 477 30 . . . cord-018437-yjvwa1ot 478 1 Further further RB cord-018437-yjvwa1ot 478 2 , , , cord-018437-yjvwa1ot 478 3 accurate accurate JJ cord-018437-yjvwa1ot 478 4 and and CC cord-018437-yjvwa1ot 478 5 standardized standardized JJ cord-018437-yjvwa1ot 478 6 data datum NNS cord-018437-yjvwa1ot 478 7 is be VBZ cord-018437-yjvwa1ot 478 8 critical critical JJ cord-018437-yjvwa1ot 478 9 for for IN cord-018437-yjvwa1ot 478 10 understanding understanding NN cord-018437-yjvwa1ot 478 11 issues issue NNS cord-018437-yjvwa1ot 478 12 related relate VBN cord-018437-yjvwa1ot 478 13 to to IN cord-018437-yjvwa1ot 478 14 transmission transmission NN cord-018437-yjvwa1ot 478 15 , , , cord-018437-yjvwa1ot 478 16 prevention prevention NN cord-018437-yjvwa1ot 478 17 , , , cord-018437-yjvwa1ot 478 18 and and CC cord-018437-yjvwa1ot 478 19 treatment treatment NN cord-018437-yjvwa1ot 478 20 of of IN cord-018437-yjvwa1ot 478 21 viral viral JJ cord-018437-yjvwa1ot 478 22 illnesses illness NNS cord-018437-yjvwa1ot 478 23 . . . cord-018437-yjvwa1ot 479 1 Establishing establish VBG cord-018437-yjvwa1ot 479 2 phylogenetic phylogenetic JJ cord-018437-yjvwa1ot 479 3 similarity similarity NN cord-018437-yjvwa1ot 479 4 to to IN cord-018437-yjvwa1ot 479 5 known know VBN cord-018437-yjvwa1ot 479 6 viral viral JJ cord-018437-yjvwa1ot 479 7 pathogens pathogen NNS cord-018437-yjvwa1ot 479 8 may may MD cord-018437-yjvwa1ot 479 9 allow allow VB cord-018437-yjvwa1ot 479 10 clinicians clinician NNS cord-018437-yjvwa1ot 479 11 to to TO cord-018437-yjvwa1ot 479 12 anticipate anticipate VB cord-018437-yjvwa1ot 479 13 the the DT cord-018437-yjvwa1ot 479 14 clinical clinical JJ cord-018437-yjvwa1ot 479 15 behavior behavior NN cord-018437-yjvwa1ot 479 16 of of IN cord-018437-yjvwa1ot 479 17 new new JJ cord-018437-yjvwa1ot 479 18 and and CC cord-018437-yjvwa1ot 479 19 emerging emerge VBG cord-018437-yjvwa1ot 479 20 viral viral JJ cord-018437-yjvwa1ot 479 21 pathogens pathogen NNS cord-018437-yjvwa1ot 479 22 , , , cord-018437-yjvwa1ot 479 23 as as IN cord-018437-yjvwa1ot 479 24 may may MD cord-018437-yjvwa1ot 479 25 be be VB cord-018437-yjvwa1ot 479 26 seen see VBN cord-018437-yjvwa1ot 479 27 when when WRB cord-018437-yjvwa1ot 479 28 virus virus NN cord-018437-yjvwa1ot 479 29 mutation mutation NN cord-018437-yjvwa1ot 479 30 results result VBZ cord-018437-yjvwa1ot 479 31 in in IN cord-018437-yjvwa1ot 479 32 acquisition acquisition NN cord-018437-yjvwa1ot 479 33 of of IN cord-018437-yjvwa1ot 479 34 new new JJ cord-018437-yjvwa1ot 479 35 pathogenic pathogenic JJ cord-018437-yjvwa1ot 479 36 mechanisms mechanism NNS cord-018437-yjvwa1ot 479 37 , , , cord-018437-yjvwa1ot 479 38 like like IN cord-018437-yjvwa1ot 479 39 changes change NNS cord-018437-yjvwa1ot 479 40 to to IN cord-018437-yjvwa1ot 479 41 antigens antigen NNS cord-018437-yjvwa1ot 479 42 associated associate VBN cord-018437-yjvwa1ot 479 43 with with IN cord-018437-yjvwa1ot 479 44 evasion evasion NN cord-018437-yjvwa1ot 479 45 of of IN cord-018437-yjvwa1ot 479 46 the the DT cord-018437-yjvwa1ot 479 47 immune immune JJ cord-018437-yjvwa1ot 479 48 response response NN cord-018437-yjvwa1ot 479 49 of of IN cord-018437-yjvwa1ot 479 50 the the DT cord-018437-yjvwa1ot 479 51 host host NN cord-018437-yjvwa1ot 479 52 species specie NNS cord-018437-yjvwa1ot 479 53 or or CC cord-018437-yjvwa1ot 479 54 changes change NNS cord-018437-yjvwa1ot 479 55 that that WDT cord-018437-yjvwa1ot 479 56 allow allow VBP cord-018437-yjvwa1ot 479 57 a a DT cord-018437-yjvwa1ot 479 58 viral viral JJ cord-018437-yjvwa1ot 479 59 pathogen pathogen NN cord-018437-yjvwa1ot 479 60 to to TO cord-018437-yjvwa1ot 479 61 jump jump VB cord-018437-yjvwa1ot 479 62 from from IN cord-018437-yjvwa1ot 479 63 one one CD cord-018437-yjvwa1ot 479 64 species species NN cord-018437-yjvwa1ot 479 65 into into IN cord-018437-yjvwa1ot 479 66 new new JJ cord-018437-yjvwa1ot 479 67 , , , cord-018437-yjvwa1ot 479 68 susceptible susceptible JJ cord-018437-yjvwa1ot 479 69 species specie NNS cord-018437-yjvwa1ot 479 70 . . . cord-018437-yjvwa1ot 480 1 As as IN cord-018437-yjvwa1ot 480 2 analytical analytical JJ cord-018437-yjvwa1ot 480 3 tools tool NNS cord-018437-yjvwa1ot 480 4 improve improve VBP cord-018437-yjvwa1ot 480 5 , , , cord-018437-yjvwa1ot 480 6 even even RB cord-018437-yjvwa1ot 480 7 more more RBR cord-018437-yjvwa1ot 480 8 informative informative JJ cord-018437-yjvwa1ot 480 9 data datum NNS cord-018437-yjvwa1ot 480 10 relevant relevant JJ cord-018437-yjvwa1ot 480 11 to to IN cord-018437-yjvwa1ot 480 12 clinical clinical JJ cord-018437-yjvwa1ot 480 13 and and CC cord-018437-yjvwa1ot 480 14 pathologic pathologic JJ cord-018437-yjvwa1ot 480 15 characteristics characteristic NNS cord-018437-yjvwa1ot 480 16 of of IN cord-018437-yjvwa1ot 480 17 viral viral JJ cord-018437-yjvwa1ot 480 18 pathogens pathogen NNS cord-018437-yjvwa1ot 480 19 is be VBZ cord-018437-yjvwa1ot 480 20 anticipated anticipate VBN cord-018437-yjvwa1ot 480 21 . . . cord-018437-yjvwa1ot 481 1 Genomewide Genomewide NNP cord-018437-yjvwa1ot 481 2 function function VB cord-018437-yjvwa1ot 481 3 conservation conservation NN cord-018437-yjvwa1ot 481 4 and and CC cord-018437-yjvwa1ot 481 5 phylogeny phylogeny NN cord-018437-yjvwa1ot 481 6 in in IN cord-018437-yjvwa1ot 481 7 the the DT cord-018437-yjvwa1ot 481 8 herpesviridae herpesviridae NNP cord-018437-yjvwa1ot 481 9 Longrange Longrange NNP cord-018437-yjvwa1ot 481 10 RNA RNA NNP cord-018437-yjvwa1ot 481 11 - - HYPH cord-018437-yjvwa1ot 481 12 RNA RNA NNP cord-018437-yjvwa1ot 481 13 interactions interaction NNS cord-018437-yjvwa1ot 481 14 circularize circularize VBP cord-018437-yjvwa1ot 481 15 the the DT cord-018437-yjvwa1ot 481 16 dengue dengue NN cord-018437-yjvwa1ot 481 17 virus virus NN cord-018437-yjvwa1ot 481 18 genome genome NN cord-018437-yjvwa1ot 482 1 The the DT cord-018437-yjvwa1ot 482 2 V v NN cord-018437-yjvwa1ot 482 3 proteins protein NNS cord-018437-yjvwa1ot 482 4 of of IN cord-018437-yjvwa1ot 482 5 paramyxoviruses paramyxovirus NNS cord-018437-yjvwa1ot 482 6 bind bind VBP cord-018437-yjvwa1ot 482 7 the the DT cord-018437-yjvwa1ot 482 8 IFN IFN NNP cord-018437-yjvwa1ot 482 9 - - HYPH cord-018437-yjvwa1ot 482 10 inducible inducible JJ cord-018437-yjvwa1ot 482 11 RNA RNA NNP cord-018437-yjvwa1ot 482 12 helicase helicase NN cord-018437-yjvwa1ot 482 13 , , , cord-018437-yjvwa1ot 482 14 mda-5 mda-5 NNP cord-018437-yjvwa1ot 482 15 , , , cord-018437-yjvwa1ot 482 16 and and CC cord-018437-yjvwa1ot 482 17 inhibit inhibit VB cord-018437-yjvwa1ot 482 18 its -PRON- PRP$ cord-018437-yjvwa1ot 482 19 activation activation NN cord-018437-yjvwa1ot 482 20 of of IN cord-018437-yjvwa1ot 482 21 the the DT cord-018437-yjvwa1ot 482 22 INF inf NN cord-018437-yjvwa1ot 482 23 - - HYPH cord-018437-yjvwa1ot 482 24 beta beta NN cord-018437-yjvwa1ot 482 25 promoter promoter NN cord-018437-yjvwa1ot 482 26 Infl Infl NNP cord-018437-yjvwa1ot 482 27 uenza uenza NNP cord-018437-yjvwa1ot 482 28 viruses virus NNS cord-018437-yjvwa1ot 482 29 , , , cord-018437-yjvwa1ot 482 30 Chap Chap NNP cord-018437-yjvwa1ot 482 31 81 81 CD cord-018437-yjvwa1ot 482 32 . . . cord-018437-yjvwa1ot 483 1 In in IN cord-018437-yjvwa1ot 483 2 : : : cord-018437-yjvwa1ot 483 3 Versalovik Versalovik NNP cord-018437-yjvwa1ot 483 4 J J NNP cord-018437-yjvwa1ot 483 5 ( ( -LRB- cord-018437-yjvwa1ot 483 6 ed ed NNP cord-018437-yjvwa1ot 483 7 ) ) -RRB- cord-018437-yjvwa1ot 483 8 Manual Manual NNP cord-018437-yjvwa1ot 483 9 of of IN cord-018437-yjvwa1ot 483 10 clinical clinical JJ cord-018437-yjvwa1ot 483 11 microbiology microbiology NN cord-018437-yjvwa1ot 483 12 DNA dna NN cord-018437-yjvwa1ot 483 13 sequence sequence NN cord-018437-yjvwa1ot 483 14 and and CC cord-018437-yjvwa1ot 483 15 expression expression NN cord-018437-yjvwa1ot 483 16 of of IN cord-018437-yjvwa1ot 483 17 the the DT cord-018437-yjvwa1ot 483 18 B95 B95 NNP cord-018437-yjvwa1ot 483 19 - - HYPH cord-018437-yjvwa1ot 483 20 8 8 CD cord-018437-yjvwa1ot 483 21 Epstein Epstein NNP cord-018437-yjvwa1ot 483 22 - - HYPH cord-018437-yjvwa1ot 483 23 Barr Barr NNP cord-018437-yjvwa1ot 483 24 virus virus NN cord-018437-yjvwa1ot 483 25 genome genome NN cord-018437-yjvwa1ot 483 26 Expression expression NN cord-018437-yjvwa1ot 483 27 of of IN cord-018437-yjvwa1ot 483 28 animal animal NN cord-018437-yjvwa1ot 483 29 virus virus NN cord-018437-yjvwa1ot 483 30 genomes genome VBZ cord-018437-yjvwa1ot 483 31 RNAs rna NNS cord-018437-yjvwa1ot 483 32 in in IN cord-018437-yjvwa1ot 483 33 the the DT cord-018437-yjvwa1ot 483 34 virion virion NN cord-018437-yjvwa1ot 483 35 of of IN cord-018437-yjvwa1ot 483 36 Kaposi Kaposi NNP cord-018437-yjvwa1ot 483 37 's 's POS cord-018437-yjvwa1ot 483 38 sarcoma sarcoma NN cord-018437-yjvwa1ot 483 39 - - HYPH cord-018437-yjvwa1ot 483 40 associated associate VBN cord-018437-yjvwa1ot 483 41 herpesvirus herpesvirus NN cord-018437-yjvwa1ot 483 42 Polyoma Polyoma NNP cord-018437-yjvwa1ot 483 43 virus virus NN cord-018437-yjvwa1ot 483 44 : : : cord-018437-yjvwa1ot 483 45 old old JJ cord-018437-yjvwa1ot 483 46 fi fi NNP cord-018437-yjvwa1ot 483 47 ndings nding NNS cord-018437-yjvwa1ot 483 48 and and CC cord-018437-yjvwa1ot 483 49 new new JJ cord-018437-yjvwa1ot 483 50 challenges challenge NNS cord-018437-yjvwa1ot 484 1 A a DT cord-018437-yjvwa1ot 484 2 new new JJ cord-018437-yjvwa1ot 484 3 classifi classifi NN cord-018437-yjvwa1ot 484 4 cation cation NN cord-018437-yjvwa1ot 484 5 for for IN cord-018437-yjvwa1ot 484 6 HIV-1 HIV-1 NNP cord-018437-yjvwa1ot 484 7 Human Human NNP cord-018437-yjvwa1ot 484 8 herpesvirus herpesvirus NNP cord-018437-yjvwa1ot 484 9 6 6 CD cord-018437-yjvwa1ot 485 1 The the DT cord-018437-yjvwa1ot 485 2 clinical clinical JJ cord-018437-yjvwa1ot 485 3 importance importance NN cord-018437-yjvwa1ot 485 4 of of IN cord-018437-yjvwa1ot 485 5 understanding understand VBG cord-018437-yjvwa1ot 485 6 the the DT cord-018437-yjvwa1ot 485 7 evolution evolution NN cord-018437-yjvwa1ot 485 8 of of IN cord-018437-yjvwa1ot 485 9 papillomaviruses papillomaviruse NNS cord-018437-yjvwa1ot 485 10 Real real JJ cord-018437-yjvwa1ot 485 11 - - HYPH cord-018437-yjvwa1ot 485 12 time time NN cord-018437-yjvwa1ot 485 13 qualitative qualitative JJ cord-018437-yjvwa1ot 485 14 PCR pcr NN cord-018437-yjvwa1ot 485 15 for for IN cord-018437-yjvwa1ot 485 16 57 57 CD cord-018437-yjvwa1ot 485 17 human human JJ cord-018437-yjvwa1ot 485 18 adenovirus adenovirus NN cord-018437-yjvwa1ot 485 19 types type NNS cord-018437-yjvwa1ot 485 20 from from IN cord-018437-yjvwa1ot 485 21 multiple multiple JJ cord-018437-yjvwa1ot 485 22 specimen specimen NN cord-018437-yjvwa1ot 485 23 sources source NNS cord-018437-yjvwa1ot 486 1 Flavivirus Flavivirus NNP cord-018437-yjvwa1ot 486 2 genome genome NN cord-018437-yjvwa1ot 486 3 organization organization NN cord-018437-yjvwa1ot 486 4 , , , cord-018437-yjvwa1ot 486 5 expression expression NN cord-018437-yjvwa1ot 486 6 , , , cord-018437-yjvwa1ot 486 7 and and CC cord-018437-yjvwa1ot 486 8 replication replication NN cord-018437-yjvwa1ot 487 1 The the DT cord-018437-yjvwa1ot 487 2 morphology morphology NN cord-018437-yjvwa1ot 487 3 of of IN cord-018437-yjvwa1ot 487 4 human human JJ cord-018437-yjvwa1ot 487 5 immunodefi immunodefi NNP cord-018437-yjvwa1ot 487 6 ciency ciency NNP cord-018437-yjvwa1ot 487 7 virus virus NN cord-018437-yjvwa1ot 487 8 ( ( -LRB- cord-018437-yjvwa1ot 487 9 HIV HIV NNP cord-018437-yjvwa1ot 487 10 ) ) -RRB- cord-018437-yjvwa1ot 487 11 by by IN cord-018437-yjvwa1ot 487 12 negative negative JJ cord-018437-yjvwa1ot 487 13 staining stain VBG cord-018437-yjvwa1ot 487 14 Confi Confi NNP cord-018437-yjvwa1ot 487 15 guration guration NN cord-018437-yjvwa1ot 487 16 and and CC cord-018437-yjvwa1ot 487 17 terminal terminal NN cord-018437-yjvwa1ot 487 18 sequences sequence NNS cord-018437-yjvwa1ot 487 19 of of IN cord-018437-yjvwa1ot 487 20 the the DT cord-018437-yjvwa1ot 487 21 simian simian JJ cord-018437-yjvwa1ot 487 22 varicella varicella NN cord-018437-yjvwa1ot 487 23 virus virus NN cord-018437-yjvwa1ot 487 24 genome genome NN cord-018437-yjvwa1ot 487 25 Isolation isolation NN cord-018437-yjvwa1ot 487 26 of of IN cord-018437-yjvwa1ot 487 27 a a DT cord-018437-yjvwa1ot 487 28 new new JJ cord-018437-yjvwa1ot 487 29 human human JJ cord-018437-yjvwa1ot 487 30 retrovirus retrovirus NN cord-018437-yjvwa1ot 487 31 from from IN cord-018437-yjvwa1ot 487 32 West west JJ cord-018437-yjvwa1ot 487 33 African african JJ cord-018437-yjvwa1ot 487 34 patients patient NNS cord-018437-yjvwa1ot 487 35 with with IN cord-018437-yjvwa1ot 487 36 AIDS AIDS NNP cord-018437-yjvwa1ot 487 37 Molecular Molecular NNP cord-018437-yjvwa1ot 487 38 cloning cloning NN cord-018437-yjvwa1ot 487 39 and and CC cord-018437-yjvwa1ot 487 40 polymorphism polymorphism NN cord-018437-yjvwa1ot 487 41 of of IN cord-018437-yjvwa1ot 487 42 the the DT cord-018437-yjvwa1ot 487 43 human human JJ cord-018437-yjvwa1ot 487 44 immune immune NN cord-018437-yjvwa1ot 487 45 defi defi NNP cord-018437-yjvwa1ot 487 46 ciency ciency NNP cord-018437-yjvwa1ot 487 47 virus virus NN cord-018437-yjvwa1ot 487 48 type type NN cord-018437-yjvwa1ot 487 49 2 2 CD cord-018437-yjvwa1ot 487 50 cDNA cdna NN cord-018437-yjvwa1ot 487 51 cloning cloning NN cord-018437-yjvwa1ot 487 52 and and CC cord-018437-yjvwa1ot 487 53 transcriptional transcriptional JJ cord-018437-yjvwa1ot 487 54 mapping mapping NN cord-018437-yjvwa1ot 487 55 of of IN cord-018437-yjvwa1ot 487 56 nine nine CD cord-018437-yjvwa1ot 487 57 polyadenylylated polyadenylylated JJ cord-018437-yjvwa1ot 487 58 RNAs rna NNS cord-018437-yjvwa1ot 487 59 encoded encode VBN cord-018437-yjvwa1ot 487 60 by by IN cord-018437-yjvwa1ot 487 61 the the DT cord-018437-yjvwa1ot 487 62 genome genome NN cord-018437-yjvwa1ot 487 63 of of IN cord-018437-yjvwa1ot 487 64 human human JJ cord-018437-yjvwa1ot 487 65 respiratory respiratory JJ cord-018437-yjvwa1ot 487 66 syncytial syncytial JJ cord-018437-yjvwa1ot 487 67 virus virus NN cord-018437-yjvwa1ot 487 68 Characterization characterization NN cord-018437-yjvwa1ot 487 69 and and CC cord-018437-yjvwa1ot 487 70 molecular molecular JJ cord-018437-yjvwa1ot 487 71 cloning cloning NN cord-018437-yjvwa1ot 487 72 of of IN cord-018437-yjvwa1ot 487 73 a a DT cord-018437-yjvwa1ot 487 74 human human JJ cord-018437-yjvwa1ot 487 75 parvovirus parvovirus NN cord-018437-yjvwa1ot 487 76 genome genome NN cord-018437-yjvwa1ot 487 77 Isolation isolation NN cord-018437-yjvwa1ot 487 78 of of IN cord-018437-yjvwa1ot 487 79 T t NN cord-018437-yjvwa1ot 487 80 - - HYPH cord-018437-yjvwa1ot 487 81 cell cell NN cord-018437-yjvwa1ot 487 82 tropic tropic NN cord-018437-yjvwa1ot 487 83 HTLV HTLV NNP cord-018437-yjvwa1ot 487 84 - - HYPH cord-018437-yjvwa1ot 487 85 III III NNP cord-018437-yjvwa1ot 487 86 - - HYPH cord-018437-yjvwa1ot 487 87 like like JJ cord-018437-yjvwa1ot 487 88 retrovirus retrovirus NN cord-018437-yjvwa1ot 487 89 from from IN cord-018437-yjvwa1ot 487 90 macaques macaque NNS cord-018437-yjvwa1ot 487 91 Structure Structure NNP cord-018437-yjvwa1ot 487 92 of of IN cord-018437-yjvwa1ot 487 93 the the DT cord-018437-yjvwa1ot 487 94 genome genome NN cord-018437-yjvwa1ot 487 95 termini terminus NNS cord-018437-yjvwa1ot 487 96 of of IN cord-018437-yjvwa1ot 487 97 varicella varicella NN cord-018437-yjvwa1ot 487 98 - - HYPH cord-018437-yjvwa1ot 487 99 zoster zoster NN cord-018437-yjvwa1ot 487 100 virus virus NN cord-018437-yjvwa1ot 488 1 The the DT cord-018437-yjvwa1ot 488 2 complete complete JJ cord-018437-yjvwa1ot 488 3 DNA dna NN cord-018437-yjvwa1ot 488 4 sequence sequence NN cord-018437-yjvwa1ot 488 5 of of IN cord-018437-yjvwa1ot 488 6 varicella varicella NN cord-018437-yjvwa1ot 488 7 - - HYPH cord-018437-yjvwa1ot 488 8 zoster zoster NN cord-018437-yjvwa1ot 488 9 virus virus NN cord-018437-yjvwa1ot 488 10 Genetic genetic JJ cord-018437-yjvwa1ot 488 11 content content NN cord-018437-yjvwa1ot 488 12 and and CC cord-018437-yjvwa1ot 488 13 evolution evolution NN cord-018437-yjvwa1ot 488 14 of of IN cord-018437-yjvwa1ot 488 15 adenoviruses adenovirus NNS cord-018437-yjvwa1ot 489 1 The the DT cord-018437-yjvwa1ot 489 2 human human JJ cord-018437-yjvwa1ot 489 3 cytomegalovirus cytomegalovirus NN cord-018437-yjvwa1ot 489 4 genome genome NN cord-018437-yjvwa1ot 489 5 revisited revisit VBD cord-018437-yjvwa1ot 489 6 : : : cord-018437-yjvwa1ot 489 7 comparison comparison NN cord-018437-yjvwa1ot 489 8 with with IN cord-018437-yjvwa1ot 489 9 the the DT cord-018437-yjvwa1ot 489 10 chimpanzee chimpanzee NN cord-018437-yjvwa1ot 489 11 cytomegalovirus cytomegalovirus NN cord-018437-yjvwa1ot 489 12 genome genome NN cord-018437-yjvwa1ot 489 13 Classifi Classifi NNP cord-018437-yjvwa1ot 489 14 cation cation NN cord-018437-yjvwa1ot 489 15 of of IN cord-018437-yjvwa1ot 489 16 papillomaviruses papillomaviruse NNS cord-018437-yjvwa1ot 489 17 Cloning Cloning NNP cord-018437-yjvwa1ot 489 18 of of IN cord-018437-yjvwa1ot 489 19 the the DT cord-018437-yjvwa1ot 489 20 human human JJ cord-018437-yjvwa1ot 489 21 parvovirus parvovirus NN cord-018437-yjvwa1ot 489 22 B19 B19 NNP cord-018437-yjvwa1ot 489 23 genome genome NN cord-018437-yjvwa1ot 489 24 and and CC cord-018437-yjvwa1ot 489 25 structural structural JJ cord-018437-yjvwa1ot 489 26 analysis analysis NN cord-018437-yjvwa1ot 489 27 of of IN cord-018437-yjvwa1ot 489 28 its -PRON- PRP$ cord-018437-yjvwa1ot 489 29 palindromic palindromic JJ cord-018437-yjvwa1ot 489 30 termini terminus NNS cord-018437-yjvwa1ot 489 31 The the DT cord-018437-yjvwa1ot 489 32 genome genome NN cord-018437-yjvwa1ot 489 33 sequence sequence NN cord-018437-yjvwa1ot 489 34 of of IN cord-018437-yjvwa1ot 489 35 herpes herpes NNP cord-018437-yjvwa1ot 489 36 simplex simplex NNP cord-018437-yjvwa1ot 489 37 virus virus NN cord-018437-yjvwa1ot 489 38 type type NN cord-018437-yjvwa1ot 489 39 2 2 CD cord-018437-yjvwa1ot 489 40 et et NNP cord-018437-yjvwa1ot 489 41 al al NNP cord-018437-yjvwa1ot 489 42 ( ( -LRB- cord-018437-yjvwa1ot 489 43 1986 1986 CD cord-018437-yjvwa1ot 489 44 ) ) -RRB- cord-018437-yjvwa1ot 490 1 Transcriptional Transcriptional NNP cord-018437-yjvwa1ot 490 2 map map NN cord-018437-yjvwa1ot 490 3 of of IN cord-018437-yjvwa1ot 490 4 the the DT cord-018437-yjvwa1ot 490 5 measles measles NNP cord-018437-yjvwa1ot 490 6 virus virus NN cord-018437-yjvwa1ot 490 7 genome genome NN cord-018437-yjvwa1ot 490 8 Functional Functional NNP cord-018437-yjvwa1ot 490 9 profi profi NNP cord-018437-yjvwa1ot 490 10 ling ling NN cord-018437-yjvwa1ot 490 11 of of IN cord-018437-yjvwa1ot 490 12 a a DT cord-018437-yjvwa1ot 490 13 human human JJ cord-018437-yjvwa1ot 490 14 cytomegalovirus cytomegalovirus NN cord-018437-yjvwa1ot 490 15 genome genome NN cord-018437-yjvwa1ot 490 16 Mutations Mutations NNPS cord-018437-yjvwa1ot 490 17 in in IN cord-018437-yjvwa1ot 490 18 the the DT cord-018437-yjvwa1ot 490 19 C c NN cord-018437-yjvwa1ot 490 20 , , , cord-018437-yjvwa1ot 490 21 D D NNP cord-018437-yjvwa1ot 490 22 , , , cord-018437-yjvwa1ot 490 23 and and CC cord-018437-yjvwa1ot 490 24 V v LS cord-018437-yjvwa1ot 490 25 open open JJ cord-018437-yjvwa1ot 490 26 reading reading NN cord-018437-yjvwa1ot 490 27 frames frame NNS cord-018437-yjvwa1ot 490 28 of of IN cord-018437-yjvwa1ot 490 29 human human JJ cord-018437-yjvwa1ot 490 30 parainfl parainfl NN cord-018437-yjvwa1ot 490 31 uenza uenza NNP cord-018437-yjvwa1ot 490 32 virus virus NN cord-018437-yjvwa1ot 490 33 type type NN cord-018437-yjvwa1ot 490 34 3 3 CD cord-018437-yjvwa1ot 490 35 attenuate attenuate VBP cord-018437-yjvwa1ot 490 36 replication replication NN cord-018437-yjvwa1ot 490 37 in in IN cord-018437-yjvwa1ot 490 38 rodents rodent NNS cord-018437-yjvwa1ot 490 39 and and CC cord-018437-yjvwa1ot 490 40 primates primate NNS cord-018437-yjvwa1ot 490 41 Henipaviruses Henipaviruses NNP cord-018437-yjvwa1ot 490 42 , , , cord-018437-yjvwa1ot 490 43 Chap Chap NNP cord-018437-yjvwa1ot 490 44 45 45 CD cord-018437-yjvwa1ot 490 45 Virus Virus NNP cord-018437-yjvwa1ot 490 46 taxonomy taxonomy NN cord-018437-yjvwa1ot 490 47 : : : cord-018437-yjvwa1ot 490 48 one one CD cord-018437-yjvwa1ot 490 49 step step NN cord-018437-yjvwa1ot 490 50 forward forward RB cord-018437-yjvwa1ot 490 51 , , , cord-018437-yjvwa1ot 490 52 two two CD cord-018437-yjvwa1ot 490 53 steps step NNS cord-018437-yjvwa1ot 490 54 back back RB cord-018437-yjvwa1ot 491 1 Varicella varicella NN cord-018437-yjvwa1ot 491 2 - - HYPH cord-018437-yjvwa1ot 491 3 zoster zoster NN cord-018437-yjvwa1ot 491 4 virus virus NN cord-018437-yjvwa1ot 491 5 DNA dna NN cord-018437-yjvwa1ot 491 6 exists exist VBZ cord-018437-yjvwa1ot 491 7 as as IN cord-018437-yjvwa1ot 491 8 two two CD cord-018437-yjvwa1ot 491 9 isomers isomer NNS cord-018437-yjvwa1ot 491 10 Importance importance NN cord-018437-yjvwa1ot 491 11 of of IN cord-018437-yjvwa1ot 491 12 both both CC cord-018437-yjvwa1ot 491 13 the the DT cord-018437-yjvwa1ot 491 14 coding coding NN cord-018437-yjvwa1ot 491 15 and and CC cord-018437-yjvwa1ot 491 16 the the DT cord-018437-yjvwa1ot 491 17 segment segment NN cord-018437-yjvwa1ot 491 18 - - HYPH cord-018437-yjvwa1ot 491 19 specifi specifi NNP cord-018437-yjvwa1ot 491 20 c c NN cord-018437-yjvwa1ot 491 21 noncoding noncoding JJ cord-018437-yjvwa1ot 491 22 regions region NNS cord-018437-yjvwa1ot 491 23 of of IN cord-018437-yjvwa1ot 491 24 the the DT cord-018437-yjvwa1ot 491 25 infl infl NNP cord-018437-yjvwa1ot 491 26 uenza uenza NNP cord-018437-yjvwa1ot 491 27 type type NN cord-018437-yjvwa1ot 491 28 A a DT cord-018437-yjvwa1ot 491 29 virus virus NN cord-018437-yjvwa1ot 491 30 NS NS NNP cord-018437-yjvwa1ot 491 31 segment segment NN cord-018437-yjvwa1ot 491 32 for for IN cord-018437-yjvwa1ot 491 33 its -PRON- PRP$ cord-018437-yjvwa1ot 491 34 effi effi NNP cord-018437-yjvwa1ot 491 35 cient cient NNP cord-018437-yjvwa1ot 491 36 incorporation incorporation NN cord-018437-yjvwa1ot 491 37 into into IN cord-018437-yjvwa1ot 491 38 virions virion NNS cord-018437-yjvwa1ot 491 39 Origin Origin NNP cord-018437-yjvwa1ot 491 40 of of IN cord-018437-yjvwa1ot 491 41 HIV-1 HIV-1 NNP cord-018437-yjvwa1ot 491 42 in in IN cord-018437-yjvwa1ot 491 43 the the DT cord-018437-yjvwa1ot 491 44 chimpanzee chimpanzee NN cord-018437-yjvwa1ot 491 45 Pan Pan NNP cord-018437-yjvwa1ot 491 46 troglodytes troglodyte NNS cord-018437-yjvwa1ot 491 47 troglodytes troglodyte NNS cord-018437-yjvwa1ot 491 48 Factors factor NNS cord-018437-yjvwa1ot 491 49 associated associate VBN cord-018437-yjvwa1ot 491 50 with with IN cord-018437-yjvwa1ot 491 51 fulminant fulminant JJ cord-018437-yjvwa1ot 491 52 liver liver NN cord-018437-yjvwa1ot 491 53 failure failure NN cord-018437-yjvwa1ot 491 54 during during IN cord-018437-yjvwa1ot 491 55 an an DT cord-018437-yjvwa1ot 491 56 outbreak outbreak NN cord-018437-yjvwa1ot 491 57 among among IN cord-018437-yjvwa1ot 491 58 injection injection NN cord-018437-yjvwa1ot 491 59 drug drug NN cord-018437-yjvwa1ot 491 60 users user NNS cord-018437-yjvwa1ot 491 61 with with IN cord-018437-yjvwa1ot 491 62 acute acute JJ cord-018437-yjvwa1ot 491 63 hepatitis hepatitis NN cord-018437-yjvwa1ot 491 64 B B NNP cord-018437-yjvwa1ot 491 65 Morphogenesis Morphogenesis NNP cord-018437-yjvwa1ot 491 66 and and CC cord-018437-yjvwa1ot 491 67 morphology morphology NN cord-018437-yjvwa1ot 491 68 of of IN cord-018437-yjvwa1ot 491 69 HIV HIV NNP cord-018437-yjvwa1ot 491 70 . . . cord-018437-yjvwa1ot 492 1 Structure structure NN cord-018437-yjvwa1ot 492 2 - - HYPH cord-018437-yjvwa1ot 492 3 function function NN cord-018437-yjvwa1ot 492 4 relations relation NNS cord-018437-yjvwa1ot 493 1 The the DT cord-018437-yjvwa1ot 493 2 DNA dna NN cord-018437-yjvwa1ot 493 3 sequence sequence NN cord-018437-yjvwa1ot 493 4 of of IN cord-018437-yjvwa1ot 493 5 human human JJ cord-018437-yjvwa1ot 493 6 herpesvirus-6 herpesvirus-6 NNP cord-018437-yjvwa1ot 493 7 : : : cord-018437-yjvwa1ot 493 8 structure structure NN cord-018437-yjvwa1ot 493 9 , , , cord-018437-yjvwa1ot 493 10 coding code VBG cord-018437-yjvwa1ot 493 11 content content NN cord-018437-yjvwa1ot 493 12 , , , cord-018437-yjvwa1ot 493 13 and and CC cord-018437-yjvwa1ot 493 14 genome genome NN cord-018437-yjvwa1ot 493 15 evolution evolution NN cord-018437-yjvwa1ot 493 16 Processing processing NN cord-018437-yjvwa1ot 493 17 of of IN cord-018437-yjvwa1ot 493 18 genome genome NN cord-018437-yjvwa1ot 493 19 5′ 5′ CD cord-018437-yjvwa1ot 493 20 termini terminus NNS cord-018437-yjvwa1ot 493 21 as as IN cord-018437-yjvwa1ot 493 22 a a DT cord-018437-yjvwa1ot 493 23 strategy strategy NN cord-018437-yjvwa1ot 493 24 of of IN cord-018437-yjvwa1ot 493 25 negative negative JJ cord-018437-yjvwa1ot 493 26 - - HYPH cord-018437-yjvwa1ot 493 27 strand strand NN cord-018437-yjvwa1ot 493 28 RNA RNA NNP cord-018437-yjvwa1ot 493 29 viruses virus NNS cord-018437-yjvwa1ot 493 30 to to TO cord-018437-yjvwa1ot 493 31 avoid avoid VB cord-018437-yjvwa1ot 493 32 RIG rig NN cord-018437-yjvwa1ot 493 33 - - . cord-018437-yjvwa1ot 493 34 Idependent Idependent NNP cord-018437-yjvwa1ot 494 1 interferon interferon NN cord-018437-yjvwa1ot 494 2 induction induction NN cord-018437-yjvwa1ot 494 3 Respiratory respiratory JJ cord-018437-yjvwa1ot 494 4 syncytial syncytial JJ cord-018437-yjvwa1ot 494 5 virus virus NN cord-018437-yjvwa1ot 494 6 and and CC cord-018437-yjvwa1ot 494 7 parainfl parainfl NN cord-018437-yjvwa1ot 494 8 uenza uenza NNP cord-018437-yjvwa1ot 494 9 virus virus NN cord-018437-yjvwa1ot 495 1 Infl Infl NNP cord-018437-yjvwa1ot 495 2 uenza uenza NNP cord-018437-yjvwa1ot 495 3 virus virus NN cord-018437-yjvwa1ot 495 4 , , , cord-018437-yjvwa1ot 495 5 Chap Chap NNP cord-018437-yjvwa1ot 495 6 42 42 CD cord-018437-yjvwa1ot 495 7 Global global JJ cord-018437-yjvwa1ot 495 8 and and CC cord-018437-yjvwa1ot 495 9 regional regional JJ cord-018437-yjvwa1ot 495 10 distribution distribution NN cord-018437-yjvwa1ot 495 11 of of IN cord-018437-yjvwa1ot 495 12 HIV-1 HIV-1 NNP cord-018437-yjvwa1ot 495 13 genetic genetic JJ cord-018437-yjvwa1ot 495 14 subtypes subtype NNS cord-018437-yjvwa1ot 495 15 and and CC cord-018437-yjvwa1ot 495 16 recombinants recombinant NNS cord-018437-yjvwa1ot 495 17 in in IN cord-018437-yjvwa1ot 495 18 Parainfl Parainfl NNP cord-018437-yjvwa1ot 495 19 uenza uenza NNP cord-018437-yjvwa1ot 495 20 viruses viruse VBZ cord-018437-yjvwa1ot 495 21 Gene Gene NNP cord-018437-yjvwa1ot 495 22 mapping mapping NN cord-018437-yjvwa1ot 495 23 of of IN cord-018437-yjvwa1ot 495 24 the the DT cord-018437-yjvwa1ot 495 25 putative putative JJ cord-018437-yjvwa1ot 495 26 structural structural JJ cord-018437-yjvwa1ot 495 27 region region NN cord-018437-yjvwa1ot 495 28 of of IN cord-018437-yjvwa1ot 495 29 the the DT cord-018437-yjvwa1ot 495 30 hepatitis hepatitis NN cord-018437-yjvwa1ot 495 31 C C NNP cord-018437-yjvwa1ot 495 32 virus virus NN cord-018437-yjvwa1ot 495 33 genome genome VBN cord-018437-yjvwa1ot 495 34 by by IN cord-018437-yjvwa1ot 495 35 in in FW cord-018437-yjvwa1ot 495 36 vitro vitro FW cord-018437-yjvwa1ot 495 37 processing processing NN cord-018437-yjvwa1ot 495 38 analysis analysis NN cord-018437-yjvwa1ot 495 39 Evolutionary evolutionary JJ cord-018437-yjvwa1ot 495 40 history history NN cord-018437-yjvwa1ot 495 41 and and CC cord-018437-yjvwa1ot 495 42 phylogeography phylogeography NN cord-018437-yjvwa1ot 495 43 of of IN cord-018437-yjvwa1ot 495 44 human human JJ cord-018437-yjvwa1ot 495 45 viruses virus NNS cord-018437-yjvwa1ot 496 1 What what WP cord-018437-yjvwa1ot 496 2 does do VBZ cord-018437-yjvwa1ot 496 3 virus virus NN cord-018437-yjvwa1ot 496 4 evolution evolution NN cord-018437-yjvwa1ot 496 5 tell tell VB cord-018437-yjvwa1ot 496 6 us -PRON- PRP cord-018437-yjvwa1ot 496 7 about about IN cord-018437-yjvwa1ot 496 8 virus virus NN cord-018437-yjvwa1ot 496 9 origins origin NNS cord-018437-yjvwa1ot 496 10 ? ? . cord-018437-yjvwa1ot 497 1 Association Association NNP cord-018437-yjvwa1ot 497 2 of of IN cord-018437-yjvwa1ot 497 3 human human JJ cord-018437-yjvwa1ot 497 4 papillomavirus papillomavirus NN cord-018437-yjvwa1ot 497 5 types type NNS cord-018437-yjvwa1ot 497 6 16 16 CD cord-018437-yjvwa1ot 497 7 and and CC cord-018437-yjvwa1ot 497 8 18 18 CD cord-018437-yjvwa1ot 497 9 E6 e6 NN cord-018437-yjvwa1ot 497 10 proteins protein NNS cord-018437-yjvwa1ot 497 11 with with IN cord-018437-yjvwa1ot 497 12 p53 p53 NN cord-018437-yjvwa1ot 497 13 Ultrastructure Ultrastructure NNP cord-018437-yjvwa1ot 497 14 of of IN cord-018437-yjvwa1ot 497 15 Hendra Hendra NNP cord-018437-yjvwa1ot 497 16 virus virus NN cord-018437-yjvwa1ot 497 17 and and CC cord-018437-yjvwa1ot 497 18 Nipah Nipah NNP cord-018437-yjvwa1ot 497 19 virus virus NN cord-018437-yjvwa1ot 497 20 within within IN cord-018437-yjvwa1ot 497 21 cultured cultured JJ cord-018437-yjvwa1ot 497 22 cells cell NNS cord-018437-yjvwa1ot 497 23 and and CC cord-018437-yjvwa1ot 497 24 host host NN cord-018437-yjvwa1ot 497 25 animals animal NNS cord-018437-yjvwa1ot 498 1 The the DT cord-018437-yjvwa1ot 498 2 international international JJ cord-018437-yjvwa1ot 498 3 code code NN cord-018437-yjvwa1ot 498 4 of of IN cord-018437-yjvwa1ot 498 5 virus virus NNP cord-018437-yjvwa1ot 498 6 classifi classifi NNP cord-018437-yjvwa1ot 498 7 cation cation NNP cord-018437-yjvwa1ot 498 8 and and CC cord-018437-yjvwa1ot 498 9 nomenclature nomenclature NN cord-018437-yjvwa1ot 498 10 Nipah Nipah NNP cord-018437-yjvwa1ot 498 11 virus virus NN cord-018437-yjvwa1ot 498 12 infection infection NN cord-018437-yjvwa1ot 498 13 in in IN cord-018437-yjvwa1ot 498 14 bats bat NNS cord-018437-yjvwa1ot 498 15 ( ( -LRB- cord-018437-yjvwa1ot 498 16 order order NN cord-018437-yjvwa1ot 498 17 Chiroptera Chiroptera NNP cord-018437-yjvwa1ot 498 18 ) ) -RRB- cord-018437-yjvwa1ot 498 19 in in IN cord-018437-yjvwa1ot 498 20 Peninsular Peninsular NNP cord-018437-yjvwa1ot 498 21 Malaysia Malaysia NNP cord-018437-yjvwa1ot 498 22 T T NNP cord-018437-yjvwa1ot 498 23 - - HYPH cord-018437-yjvwa1ot 498 24 lymphocyte lymphocyte NN cord-018437-yjvwa1ot 498 25 T4 t4 NN cord-018437-yjvwa1ot 498 26 molecule molecule NN cord-018437-yjvwa1ot 498 27 behaves behave VBZ cord-018437-yjvwa1ot 498 28 as as IN cord-018437-yjvwa1ot 498 29 the the DT cord-018437-yjvwa1ot 498 30 receptor receptor NN cord-018437-yjvwa1ot 498 31 for for IN cord-018437-yjvwa1ot 498 32 human human JJ cord-018437-yjvwa1ot 498 33 retrovirus retrovirus NN cord-018437-yjvwa1ot 498 34 LAV LAV NNP cord-018437-yjvwa1ot 498 35 Paramyxovirus Paramyxovirus NNP cord-018437-yjvwa1ot 498 36 mRNA mRNA NNP cord-018437-yjvwa1ot 498 37 editing editing NN cord-018437-yjvwa1ot 498 38 , , , cord-018437-yjvwa1ot 498 39 the the DT cord-018437-yjvwa1ot 498 40 " " `` cord-018437-yjvwa1ot 498 41 rule rule NN cord-018437-yjvwa1ot 498 42 of of IN cord-018437-yjvwa1ot 498 43 six six CD cord-018437-yjvwa1ot 498 44 " " '' cord-018437-yjvwa1ot 498 45 and and CC cord-018437-yjvwa1ot 498 46 error error NN cord-018437-yjvwa1ot 498 47 catastrophe catastrophe NN cord-018437-yjvwa1ot 498 48 : : : cord-018437-yjvwa1ot 498 49 a a DT cord-018437-yjvwa1ot 498 50 hypothesis hypothesis NN cord-018437-yjvwa1ot 498 51 Proposal Proposal NNP cord-018437-yjvwa1ot 498 52 for for IN cord-018437-yjvwa1ot 498 53 a a DT cord-018437-yjvwa1ot 498 54 revised revised JJ cord-018437-yjvwa1ot 498 55 taxonomy taxonomy NN cord-018437-yjvwa1ot 498 56 of of IN cord-018437-yjvwa1ot 498 57 the the DT cord-018437-yjvwa1ot 498 58 family family NN cord-018437-yjvwa1ot 498 59 Filoviridae Filoviridae NNP cord-018437-yjvwa1ot 498 60 : : : cord-018437-yjvwa1ot 498 61 classifi classifi NNP cord-018437-yjvwa1ot 498 62 cation cation NN cord-018437-yjvwa1ot 498 63 , , , cord-018437-yjvwa1ot 498 64 names name NNS cord-018437-yjvwa1ot 498 65 of of IN cord-018437-yjvwa1ot 498 66 taxa taxon NNS cord-018437-yjvwa1ot 498 67 and and CC cord-018437-yjvwa1ot 498 68 viruses virus NNS cord-018437-yjvwa1ot 498 69 , , , cord-018437-yjvwa1ot 498 70 and and CC cord-018437-yjvwa1ot 498 71 virus virus NN cord-018437-yjvwa1ot 498 72 abbreviations abbreviation NNS cord-018437-yjvwa1ot 498 73 Partitioning partition VBG cord-018437-yjvwa1ot 498 74 the the DT cord-018437-yjvwa1ot 498 75 genetic genetic JJ cord-018437-yjvwa1ot 498 76 diversity diversity NN cord-018437-yjvwa1ot 498 77 of of IN cord-018437-yjvwa1ot 498 78 a a DT cord-018437-yjvwa1ot 498 79 virus virus NN cord-018437-yjvwa1ot 498 80 family family NN cord-018437-yjvwa1ot 498 81 : : : cord-018437-yjvwa1ot 498 82 approach approach VB cord-018437-yjvwa1ot 498 83 and and CC cord-018437-yjvwa1ot 498 84 evaluation evaluation NN cord-018437-yjvwa1ot 498 85 through through IN cord-018437-yjvwa1ot 498 86 a a DT cord-018437-yjvwa1ot 498 87 case case NN cord-018437-yjvwa1ot 498 88 study study NN cord-018437-yjvwa1ot 498 89 of of IN cord-018437-yjvwa1ot 498 90 picornaviruses picornaviruses NNP cord-018437-yjvwa1ot 498 91 Toward toward IN cord-018437-yjvwa1ot 498 92 genetics genetics NN cord-018437-yjvwa1ot 498 93 - - HYPH cord-018437-yjvwa1ot 498 94 based base VBN cord-018437-yjvwa1ot 498 95 virus virus NN cord-018437-yjvwa1ot 498 96 taxonomy taxonomy NN cord-018437-yjvwa1ot 498 97 : : : cord-018437-yjvwa1ot 498 98 comparative comparative JJ cord-018437-yjvwa1ot 498 99 analysis analysis NN cord-018437-yjvwa1ot 498 100 of of IN cord-018437-yjvwa1ot 498 101 a a DT cord-018437-yjvwa1ot 498 102 geneticsbased geneticsbased JJ cord-018437-yjvwa1ot 498 103 classifi classifi NNP cord-018437-yjvwa1ot 498 104 cation cation NN cord-018437-yjvwa1ot 498 105 and and CC cord-018437-yjvwa1ot 498 106 the the DT cord-018437-yjvwa1ot 498 107 taxonomy taxonomy NN cord-018437-yjvwa1ot 498 108 of of IN cord-018437-yjvwa1ot 498 109 picornaviruses picornaviruses NNP cord-018437-yjvwa1ot 498 110 Taxonomy Taxonomy NNP cord-018437-yjvwa1ot 498 111 and and CC cord-018437-yjvwa1ot 498 112 classifi classifi NNP cord-018437-yjvwa1ot 498 113 cation cation NN cord-018437-yjvwa1ot 498 114 of of IN cord-018437-yjvwa1ot 498 115 viruses virus NNS cord-018437-yjvwa1ot 498 116 , , , cord-018437-yjvwa1ot 498 117 Chap Chap NNP cord-018437-yjvwa1ot 498 118 75 75 CD cord-018437-yjvwa1ot 498 119 . . . cord-018437-yjvwa1ot 499 1 In in IN cord-018437-yjvwa1ot 499 2 : : : cord-018437-yjvwa1ot 499 3 Versalovic Versalovic NNP cord-018437-yjvwa1ot 499 4 J J NNP cord-018437-yjvwa1ot 499 5 ( ( -LRB- cord-018437-yjvwa1ot 499 6 ed ed NN cord-018437-yjvwa1ot 499 7 ) ) -RRB- cord-018437-yjvwa1ot 499 8 Manual Manual NNP cord-018437-yjvwa1ot 499 9 of of IN cord-018437-yjvwa1ot 499 10 clinical clinical JJ cord-018437-yjvwa1ot 499 11 microbiology microbiology NN cord-018437-yjvwa1ot 499 12 Hepatitis Hepatitis NNP cord-018437-yjvwa1ot 499 13 B B NNP cord-018437-yjvwa1ot 499 14 : : : cord-018437-yjvwa1ot 499 15 the the DT cord-018437-yjvwa1ot 499 16 virus virus NN cord-018437-yjvwa1ot 499 17 and and CC cord-018437-yjvwa1ot 499 18 disease disease NN cord-018437-yjvwa1ot 499 19 Hepatitis Hepatitis NNP cord-018437-yjvwa1ot 499 20 B B NNP cord-018437-yjvwa1ot 499 21 viral viral JJ cord-018437-yjvwa1ot 499 22 factors factor NNS cord-018437-yjvwa1ot 499 23 and and CC cord-018437-yjvwa1ot 499 24 clinical clinical JJ cord-018437-yjvwa1ot 499 25 outcomes outcome NNS cord-018437-yjvwa1ot 499 26 of of IN cord-018437-yjvwa1ot 499 27 chronic chronic JJ cord-018437-yjvwa1ot 499 28 hepatitis hepatitis NN cord-018437-yjvwa1ot 499 29 B B NNP cord-018437-yjvwa1ot 499 30 Molecular Molecular NNP cord-018437-yjvwa1ot 499 31 analysis analysis NN cord-018437-yjvwa1ot 499 32 of of IN cord-018437-yjvwa1ot 499 33 the the DT cord-018437-yjvwa1ot 499 34 prototype prototype NN cord-018437-yjvwa1ot 499 35 coxsackievirus coxsackievirus NNP cord-018437-yjvwa1ot 499 36 B5 B5 NNP cord-018437-yjvwa1ot 499 37 genome genome NN cord-018437-yjvwa1ot 499 38 Global Global NNP cord-018437-yjvwa1ot 499 39 identifi identifi NN cord-018437-yjvwa1ot 499 40 cation cation NN cord-018437-yjvwa1ot 499 41 of of IN cord-018437-yjvwa1ot 499 42 three three CD cord-018437-yjvwa1ot 499 43 major major JJ cord-018437-yjvwa1ot 499 44 genotypes genotype NNS cord-018437-yjvwa1ot 499 45 of of IN cord-018437-yjvwa1ot 499 46 varicella varicella NN cord-018437-yjvwa1ot 499 47 - - HYPH cord-018437-yjvwa1ot 499 48 zoster zoster NN cord-018437-yjvwa1ot 499 49 virus virus NN cord-018437-yjvwa1ot 499 50 : : : cord-018437-yjvwa1ot 499 51 longitudinal longitudinal JJ cord-018437-yjvwa1ot 499 52 clustering clustering NN cord-018437-yjvwa1ot 499 53 and and CC cord-018437-yjvwa1ot 499 54 strategies strategy NNS cord-018437-yjvwa1ot 499 55 for for IN cord-018437-yjvwa1ot 499 56 genotyping genotype VBG cord-018437-yjvwa1ot 499 57 The the DT cord-018437-yjvwa1ot 499 58 ubiquitous ubiquitous JJ cord-018437-yjvwa1ot 499 59 glucose glucose NN cord-018437-yjvwa1ot 499 60 transporter transporter NN cord-018437-yjvwa1ot 499 61 GLUT-1 GLUT-1 NNP cord-018437-yjvwa1ot 499 62 is be VBZ cord-018437-yjvwa1ot 499 63 a a DT cord-018437-yjvwa1ot 499 64 receptor receptor NN cord-018437-yjvwa1ot 499 65 for for IN cord-018437-yjvwa1ot 499 66 HTLV HTLV NNP cord-018437-yjvwa1ot 500 1 The the DT cord-018437-yjvwa1ot 500 2 genome genome NN cord-018437-yjvwa1ot 500 3 sequence sequence NN cord-018437-yjvwa1ot 500 4 of of IN cord-018437-yjvwa1ot 500 5 the the DT cord-018437-yjvwa1ot 500 6 SARS SARS NNP cord-018437-yjvwa1ot 500 7 - - HYPH cord-018437-yjvwa1ot 500 8 associated associate VBN cord-018437-yjvwa1ot 500 9 coronavirus coronavirus NN cord-018437-yjvwa1ot 500 10 Isolation isolation NN cord-018437-yjvwa1ot 500 11 of of IN cord-018437-yjvwa1ot 500 12 a a DT cord-018437-yjvwa1ot 500 13 simian simian JJ cord-018437-yjvwa1ot 500 14 immunodefi immunodefi NNP cord-018437-yjvwa1ot 500 15 ciency ciency NNP cord-018437-yjvwa1ot 500 16 virus virus NN cord-018437-yjvwa1ot 500 17 related relate VBN cord-018437-yjvwa1ot 500 18 to to IN cord-018437-yjvwa1ot 500 19 human human JJ cord-018437-yjvwa1ot 500 20 immunodefi immunodefi NNP cord-018437-yjvwa1ot 500 21 ciency ciency NNP cord-018437-yjvwa1ot 500 22 virus virus NN cord-018437-yjvwa1ot 500 23 type type NN cord-018437-yjvwa1ot 500 24 2 2 CD cord-018437-yjvwa1ot 500 25 from from IN cord-018437-yjvwa1ot 500 26 a a DT cord-018437-yjvwa1ot 500 27 West west JJ cord-018437-yjvwa1ot 500 28 African african JJ cord-018437-yjvwa1ot 500 29 pet pet JJ cord-018437-yjvwa1ot 500 30 sooty sooty JJ cord-018437-yjvwa1ot 500 31 mangabey mangabey NNP cord-018437-yjvwa1ot 500 32 Structure Structure NNP cord-018437-yjvwa1ot 500 33 and and CC cord-018437-yjvwa1ot 500 34 function function NN cord-018437-yjvwa1ot 500 35 of of IN cord-018437-yjvwa1ot 500 36 the the DT cord-018437-yjvwa1ot 500 37 infl infl NNP cord-018437-yjvwa1ot 500 38 uenza uenza NNP cord-018437-yjvwa1ot 500 39 virus virus NN cord-018437-yjvwa1ot 500 40 genome genome NNP cord-018437-yjvwa1ot 501 1 The the DT cord-018437-yjvwa1ot 501 2 application application NN cord-018437-yjvwa1ot 501 3 of of IN cord-018437-yjvwa1ot 501 4 molecular molecular JJ cord-018437-yjvwa1ot 501 5 phylogenetics phylogenetic NNS cord-018437-yjvwa1ot 501 6 to to IN cord-018437-yjvwa1ot 501 7 the the DT cord-018437-yjvwa1ot 501 8 analysis analysis NN cord-018437-yjvwa1ot 501 9 of of IN cord-018437-yjvwa1ot 501 10 viral viral JJ cord-018437-yjvwa1ot 501 11 genome genome NN cord-018437-yjvwa1ot 501 12 diversity diversity NN cord-018437-yjvwa1ot 501 13 and and CC cord-018437-yjvwa1ot 501 14 evolution evolution NN cord-018437-yjvwa1ot 501 15 Topics topic NNS cord-018437-yjvwa1ot 501 16 in in IN cord-018437-yjvwa1ot 501 17 herpesvirus herpesvirus NN cord-018437-yjvwa1ot 501 18 genomics genomic NNS cord-018437-yjvwa1ot 501 19 and and CC cord-018437-yjvwa1ot 501 20 evolution evolution NN cord-018437-yjvwa1ot 501 21 Bunyaviridae Bunyaviridae NNP cord-018437-yjvwa1ot 501 22 : : : cord-018437-yjvwa1ot 501 23 bunyaviruses bunyaviruses NNP cord-018437-yjvwa1ot 501 24 , , , cord-018437-yjvwa1ot 501 25 phleboviruses phleboviruses NNP cord-018437-yjvwa1ot 501 26 , , , cord-018437-yjvwa1ot 501 27 nairoviruses nairoviruse NNS cord-018437-yjvwa1ot 501 28 , , , cord-018437-yjvwa1ot 501 29 and and CC cord-018437-yjvwa1ot 501 30 hantaviruses hantaviruses NNP cord-018437-yjvwa1ot 501 31 , , , cord-018437-yjvwa1ot 501 32 Chap Chap NNP cord-018437-yjvwa1ot 501 33 43 43 CD cord-018437-yjvwa1ot 501 34 Site site NN cord-018437-yjvwa1ot 501 35 - - HYPH cord-018437-yjvwa1ot 501 36 specifi specifi NN cord-018437-yjvwa1ot 501 37 c c NN cord-018437-yjvwa1ot 501 38 inversion inversion NN cord-018437-yjvwa1ot 501 39 sequences sequence NNS cord-018437-yjvwa1ot 501 40 of of IN cord-018437-yjvwa1ot 501 41 the the DT cord-018437-yjvwa1ot 501 42 herpes herpes NNP cord-018437-yjvwa1ot 501 43 simplex simplex NNP cord-018437-yjvwa1ot 501 44 virus virus NN cord-018437-yjvwa1ot 501 45 genome genome NN cord-018437-yjvwa1ot 501 46 : : : cord-018437-yjvwa1ot 501 47 domain domain NN cord-018437-yjvwa1ot 501 48 and and CC cord-018437-yjvwa1ot 501 49 structural structural NN cord-018437-yjvwa1ot 501 50 features feature VBZ cord-018437-yjvwa1ot 501 51 Poliovirus Poliovirus NNP cord-018437-yjvwa1ot 501 52 polypeptide polypeptide NN cord-018437-yjvwa1ot 501 53 precursors precursor NNS cord-018437-yjvwa1ot 501 54 : : : cord-018437-yjvwa1ot 501 55 expression expression NN cord-018437-yjvwa1ot 501 56 in in IN cord-018437-yjvwa1ot 501 57 vitro vitro FW cord-018437-yjvwa1ot 501 58 and and CC cord-018437-yjvwa1ot 501 59 processing processing NN cord-018437-yjvwa1ot 501 60 by by IN cord-018437-yjvwa1ot 501 61 exogenous exogenous JJ cord-018437-yjvwa1ot 501 62 3C 3C NNP cord-018437-yjvwa1ot 501 63 and and CC cord-018437-yjvwa1ot 501 64 2A 2A NNP cord-018437-yjvwa1ot 501 65 proteinases proteinases NNP cord-018437-yjvwa1ot 501 66 Complete Complete NNP cord-018437-yjvwa1ot 501 67 nucleotide nucleotide JJ cord-018437-yjvwa1ot 501 68 sequence sequence NN cord-018437-yjvwa1ot 501 69 of of IN cord-018437-yjvwa1ot 501 70 dengue dengue NN cord-018437-yjvwa1ot 501 71 type type NN cord-018437-yjvwa1ot 502 1 3 3 CD cord-018437-yjvwa1ot 502 2 virus virus NN cord-018437-yjvwa1ot 502 3 genome genome NN cord-018437-yjvwa1ot 502 4 RNA RNA NNP cord-018437-yjvwa1ot 502 5 Estimated estimate VBN cord-018437-yjvwa1ot 502 6 global global JJ cord-018437-yjvwa1ot 502 7 distribution distribution NN cord-018437-yjvwa1ot 502 8 and and CC cord-018437-yjvwa1ot 502 9 regional regional JJ cord-018437-yjvwa1ot 502 10 spread spread NN cord-018437-yjvwa1ot 502 11 of of IN cord-018437-yjvwa1ot 502 12 HIV-1 HIV-1 NNP cord-018437-yjvwa1ot 502 13 genetic genetic JJ cord-018437-yjvwa1ot 502 14 subtypes subtype NNS cord-018437-yjvwa1ot 502 15 in in IN cord-018437-yjvwa1ot 502 16 the the DT cord-018437-yjvwa1ot 502 17 year year NN cord-018437-yjvwa1ot 502 18 2000 2000 CD cord-018437-yjvwa1ot 503 1 Enteroviruses Enteroviruses NNP cord-018437-yjvwa1ot 503 2 : : : cord-018437-yjvwa1ot 503 3 polioviruses poliovirus NNS cord-018437-yjvwa1ot 503 4 , , , cord-018437-yjvwa1ot 503 5 coxsackieviruses coxsackieviruses NNP cord-018437-yjvwa1ot 503 6 , , , cord-018437-yjvwa1ot 503 7 echoviruses echovirus NNS cord-018437-yjvwa1ot 503 8 , , , cord-018437-yjvwa1ot 503 9 and and CC cord-018437-yjvwa1ot 503 10 newer new JJR cord-018437-yjvwa1ot 503 11 enteroviruses enterovirus NNS cord-018437-yjvwa1ot 503 12 , , , cord-018437-yjvwa1ot 503 13 Chapter chapter NN cord-018437-yjvwa1ot 503 14 25 25 CD cord-018437-yjvwa1ot 503 15 Isolation isolation NN cord-018437-yjvwa1ot 503 16 and and CC cord-018437-yjvwa1ot 503 17 partial partial JJ cord-018437-yjvwa1ot 503 18 characterization characterization NN cord-018437-yjvwa1ot 503 19 of of IN cord-018437-yjvwa1ot 503 20 an an DT cord-018437-yjvwa1ot 503 21 HIV HIV NNP cord-018437-yjvwa1ot 503 22 - - HYPH cord-018437-yjvwa1ot 503 23 related relate VBN cord-018437-yjvwa1ot 503 24 virus virus NN cord-018437-yjvwa1ot 503 25 occurring occur VBG cord-018437-yjvwa1ot 503 26 naturally naturally RB cord-018437-yjvwa1ot 503 27 in in IN cord-018437-yjvwa1ot 503 28 chimpanzees chimpanzee NNS cord-018437-yjvwa1ot 503 29 in in IN cord-018437-yjvwa1ot 503 30 Gabon Gabon NNP cord-018437-yjvwa1ot 503 31 Arenaviruses Arenaviruses NNP cord-018437-yjvwa1ot 503 32 , , , cord-018437-yjvwa1ot 503 33 Chap Chap NNP cord-018437-yjvwa1ot 503 34 44 44 CD cord-018437-yjvwa1ot 504 1 The the DT cord-018437-yjvwa1ot 504 2 size size NN cord-018437-yjvwa1ot 504 3 and and CC cord-018437-yjvwa1ot 504 4 conformation conformation NN cord-018437-yjvwa1ot 504 5 of of IN cord-018437-yjvwa1ot 504 6 Kaposi Kaposi NNP cord-018437-yjvwa1ot 504 7 's 's POS cord-018437-yjvwa1ot 504 8 sarcoma sarcoma NN cord-018437-yjvwa1ot 504 9 - - HYPH cord-018437-yjvwa1ot 504 10 associated associate VBN cord-018437-yjvwa1ot 504 11 herpesvirus herpesvirus NN cord-018437-yjvwa1ot 504 12 ( ( -LRB- cord-018437-yjvwa1ot 504 13 human human JJ cord-018437-yjvwa1ot 504 14 herpesvirus herpesvirus NN cord-018437-yjvwa1ot 504 15 8) 8) NNP cord-018437-yjvwa1ot 504 16 DNA DNA NNP cord-018437-yjvwa1ot 504 17 in in IN cord-018437-yjvwa1ot 504 18 infected infected JJ cord-018437-yjvwa1ot 504 19 cells cell NNS cord-018437-yjvwa1ot 504 20 and and CC cord-018437-yjvwa1ot 504 21 virions virion NNS cord-018437-yjvwa1ot 504 22 Characterization characterization NN cord-018437-yjvwa1ot 504 23 of of IN cord-018437-yjvwa1ot 504 24 a a DT cord-018437-yjvwa1ot 504 25 novel novel JJ cord-018437-yjvwa1ot 504 26 coronavirus coronavirus NN cord-018437-yjvwa1ot 504 27 associated associate VBN cord-018437-yjvwa1ot 504 28 with with IN cord-018437-yjvwa1ot 504 29 severe severe JJ cord-018437-yjvwa1ot 504 30 acute acute JJ cord-018437-yjvwa1ot 504 31 respiratory respiratory JJ cord-018437-yjvwa1ot 504 32 syndrome syndrome NN cord-018437-yjvwa1ot 504 33 Nucleotide nucleotide JJ cord-018437-yjvwa1ot 504 34 sequence sequence NN cord-018437-yjvwa1ot 504 35 of of IN cord-018437-yjvwa1ot 504 36 the the DT cord-018437-yjvwa1ot 504 37 Kaposi Kaposi NNP cord-018437-yjvwa1ot 504 38 sarcoma sarcoma NN cord-018437-yjvwa1ot 504 39 - - HYPH cord-018437-yjvwa1ot 504 40 associated associate VBN cord-018437-yjvwa1ot 504 41 herpesvirus herpesvirus NN cord-018437-yjvwa1ot 504 42 ( ( -LRB- cord-018437-yjvwa1ot 504 43 HHV8 HHV8 NNP cord-018437-yjvwa1ot 504 44 ) ) -RRB- cord-018437-yjvwa1ot 504 45 Human Human NNP cord-018437-yjvwa1ot 504 46 bocavirus bocavirus NN cord-018437-yjvwa1ot 504 47 : : : cord-018437-yjvwa1ot 504 48 passenger passenger NN cord-018437-yjvwa1ot 504 49 or or CC cord-018437-yjvwa1ot 504 50 pathogen pathogen NN cord-018437-yjvwa1ot 504 51 in in IN cord-018437-yjvwa1ot 504 52 acute acute JJ cord-018437-yjvwa1ot 504 53 respiratory respiratory JJ cord-018437-yjvwa1ot 504 54 tract tract NN cord-018437-yjvwa1ot 504 55 infections infection NNS cord-018437-yjvwa1ot 504 56 ? ? . cord-018437-yjvwa1ot 505 1 Nucleotide nucleotide JJ cord-018437-yjvwa1ot 505 2 sequence sequence NN cord-018437-yjvwa1ot 505 3 and and CC cord-018437-yjvwa1ot 505 4 genome genome NN cord-018437-yjvwa1ot 505 5 organization organization NN cord-018437-yjvwa1ot 505 6 of of IN cord-018437-yjvwa1ot 505 7 human human JJ cord-018437-yjvwa1ot 505 8 parvovirus parvovirus NN cord-018437-yjvwa1ot 505 9 B19 B19 NNP cord-018437-yjvwa1ot 505 10 isolated isolate VBN cord-018437-yjvwa1ot 505 11 from from IN cord-018437-yjvwa1ot 505 12 the the DT cord-018437-yjvwa1ot 505 13 serum serum NN cord-018437-yjvwa1ot 505 14 of of IN cord-018437-yjvwa1ot 505 15 a a DT cord-018437-yjvwa1ot 505 16 child child NN cord-018437-yjvwa1ot 505 17 during during IN cord-018437-yjvwa1ot 505 18 aplastic aplastic JJ cord-018437-yjvwa1ot 505 19 crisis crisis NN cord-018437-yjvwa1ot 505 20 CXCR4 CXCR4 NNS cord-018437-yjvwa1ot 505 21 as as IN cord-018437-yjvwa1ot 505 22 a a DT cord-018437-yjvwa1ot 505 23 functional functional JJ cord-018437-yjvwa1ot 505 24 coreceptor coreceptor NN cord-018437-yjvwa1ot 505 25 for for IN cord-018437-yjvwa1ot 505 26 human human JJ cord-018437-yjvwa1ot 505 27 immunodeficiency immunodeficiency NN cord-018437-yjvwa1ot 505 28 virus virus NN cord-018437-yjvwa1ot 505 29 type type NN cord-018437-yjvwa1ot 505 30 1 1 CD cord-018437-yjvwa1ot 505 31 infection infection NN cord-018437-yjvwa1ot 505 32 of of IN cord-018437-yjvwa1ot 505 33 primary primary JJ cord-018437-yjvwa1ot 505 34 macrophages macrophage NNS cord-018437-yjvwa1ot 506 1 The the DT cord-018437-yjvwa1ot 506 2 genome genome NN cord-018437-yjvwa1ot 506 3 length length NN cord-018437-yjvwa1ot 506 4 of of IN cord-018437-yjvwa1ot 506 5 human human JJ cord-018437-yjvwa1ot 506 6 parainfl parainfl NN cord-018437-yjvwa1ot 506 7 uenza uenza NNP cord-018437-yjvwa1ot 506 8 virus virus NN cord-018437-yjvwa1ot 506 9 type type NNP cord-018437-yjvwa1ot 506 10 2 2 CD cord-018437-yjvwa1ot 506 11 follows follow VBZ cord-018437-yjvwa1ot 506 12 the the DT cord-018437-yjvwa1ot 506 13 rule rule NN cord-018437-yjvwa1ot 506 14 of of IN cord-018437-yjvwa1ot 506 15 six six CD cord-018437-yjvwa1ot 506 16 , , , cord-018437-yjvwa1ot 506 17 and and CC cord-018437-yjvwa1ot 506 18 recombinant recombinant JJ cord-018437-yjvwa1ot 506 19 viruses virus NNS cord-018437-yjvwa1ot 506 20 recovered recover VBN cord-018437-yjvwa1ot 506 21 from from IN cord-018437-yjvwa1ot 506 22 non non JJ cord-018437-yjvwa1ot 506 23 - - JJ cord-018437-yjvwa1ot 506 24 poly poly JJ cord-018437-yjvwa1ot 506 25 - - HYPH cord-018437-yjvwa1ot 506 26 hexameric hexameric JJ cord-018437-yjvwa1ot 506 27 - - HYPH cord-018437-yjvwa1ot 506 28 length length NN cord-018437-yjvwa1ot 506 29 antigenomic antigenomic NN cord-018437-yjvwa1ot 506 30 cDNAs cdnas ADD cord-018437-yjvwa1ot 507 1 contain contain VB cord-018437-yjvwa1ot 507 2 a a DT cord-018437-yjvwa1ot 507 3 biased biased JJ cord-018437-yjvwa1ot 507 4 distribution distribution NN cord-018437-yjvwa1ot 507 5 of of IN cord-018437-yjvwa1ot 507 6 correcting correct VBG cord-018437-yjvwa1ot 507 7 mutations mutation NNS cord-018437-yjvwa1ot 507 8 Respiratory respiratory JJ cord-018437-yjvwa1ot 507 9 syncytial syncytial JJ cord-018437-yjvwa1ot 507 10 virus virus NN cord-018437-yjvwa1ot 507 11 nonstructural nonstructural JJ cord-018437-yjvwa1ot 507 12 proteins protein NNS cord-018437-yjvwa1ot 507 13 decrease decrease VBP cord-018437-yjvwa1ot 507 14 levels level NNS cord-018437-yjvwa1ot 507 15 of of IN cord-018437-yjvwa1ot 507 16 multiple multiple JJ cord-018437-yjvwa1ot 507 17 members member NNS cord-018437-yjvwa1ot 507 18 of of IN cord-018437-yjvwa1ot 507 19 the the DT cord-018437-yjvwa1ot 507 20 cellular cellular JJ cord-018437-yjvwa1ot 507 21 interferon interferon NN cord-018437-yjvwa1ot 507 22 pathways pathway NNS cord-018437-yjvwa1ot 508 1 Infl Infl NNP cord-018437-yjvwa1ot 508 2 uenza uenza NNP cord-018437-yjvwa1ot 508 3 virus virus NN cord-018437-yjvwa1ot 508 4 evolution evolution NN cord-018437-yjvwa1ot 508 5 , , , cord-018437-yjvwa1ot 508 6 host host NN cord-018437-yjvwa1ot 508 7 adaptation adaptation NN cord-018437-yjvwa1ot 508 8 , , , cord-018437-yjvwa1ot 508 9 and and CC cord-018437-yjvwa1ot 508 10 pandemic pandemic NN cord-018437-yjvwa1ot 508 11 formation formation NN cord-018437-yjvwa1ot 508 12 Mechanisms mechanism NNS cord-018437-yjvwa1ot 508 13 and and CC cord-018437-yjvwa1ot 508 14 enzymes enzyme NNS cord-018437-yjvwa1ot 508 15 involved involve VBN cord-018437-yjvwa1ot 508 16 in in IN cord-018437-yjvwa1ot 508 17 SARS SARS NNP cord-018437-yjvwa1ot 508 18 coronavirus coronavirus NN cord-018437-yjvwa1ot 508 19 genome genome NN cord-018437-yjvwa1ot 508 20 expression expression NN cord-018437-yjvwa1ot 508 21 Conserved Conserved NNP cord-018437-yjvwa1ot 508 22 RNA RNA NNP cord-018437-yjvwa1ot 508 23 secondary secondary JJ cord-018437-yjvwa1ot 508 24 structures structure NNS cord-018437-yjvwa1ot 508 25 in in IN cord-018437-yjvwa1ot 508 26 Flaviviridae Flaviviridae NNP cord-018437-yjvwa1ot 508 27 genomes genome NNS cord-018437-yjvwa1ot 508 28 Analysis Analysis NNP cord-018437-yjvwa1ot 508 29 of of IN cord-018437-yjvwa1ot 508 30 the the DT cord-018437-yjvwa1ot 508 31 genomic genomic JJ cord-018437-yjvwa1ot 508 32 sequence sequence NN cord-018437-yjvwa1ot 508 33 of of IN cord-018437-yjvwa1ot 508 34 a a DT cord-018437-yjvwa1ot 508 35 human human JJ cord-018437-yjvwa1ot 508 36 metapneumovirus metapneumovirus NN cord-018437-yjvwa1ot 508 37 Manual Manual NNP cord-018437-yjvwa1ot 508 38 of of IN cord-018437-yjvwa1ot 508 39 clinical clinical JJ cord-018437-yjvwa1ot 508 40 microbiology microbiology NNP cord-018437-yjvwa1ot 508 41 Human Human NNP cord-018437-yjvwa1ot 508 42 bocavirus bocavirus NNP cord-018437-yjvwa1ot 508 43 , , , cord-018437-yjvwa1ot 508 44 a a DT cord-018437-yjvwa1ot 508 45 respiratory respiratory JJ cord-018437-yjvwa1ot 508 46 and and CC cord-018437-yjvwa1ot 508 47 enteric enteric JJ cord-018437-yjvwa1ot 508 48 virus virus NN cord-018437-yjvwa1ot 508 49 HIV-1 HIV-1 NNP cord-018437-yjvwa1ot 508 50 subtype subtype NN cord-018437-yjvwa1ot 508 51 distribution distribution NN cord-018437-yjvwa1ot 508 52 and and CC cord-018437-yjvwa1ot 508 53 the the DT cord-018437-yjvwa1ot 508 54 problem problem NN cord-018437-yjvwa1ot 508 55 of of IN cord-018437-yjvwa1ot 508 56 drug drug NN cord-018437-yjvwa1ot 508 57 resistance resistance NN cord-018437-yjvwa1ot 509 1 The the DT cord-018437-yjvwa1ot 509 2 exceptionally exceptionally RB cord-018437-yjvwa1ot 509 3 large large JJ cord-018437-yjvwa1ot 509 4 genome genome NN cord-018437-yjvwa1ot 509 5 of of IN cord-018437-yjvwa1ot 509 6 hendra hendra NNP cord-018437-yjvwa1ot 509 7 virus virus NN cord-018437-yjvwa1ot 509 8 : : : cord-018437-yjvwa1ot 509 9 support support NN cord-018437-yjvwa1ot 509 10 for for IN cord-018437-yjvwa1ot 509 11 the the DT cord-018437-yjvwa1ot 509 12 creation creation NN cord-018437-yjvwa1ot 509 13 of of IN cord-018437-yjvwa1ot 509 14 a a DT cord-018437-yjvwa1ot 509 15 new new JJ cord-018437-yjvwa1ot 509 16 genus genus NN cord-018437-yjvwa1ot 509 17 within within IN cord-018437-yjvwa1ot 509 18 the the DT cord-018437-yjvwa1ot 509 19 family family NN cord-018437-yjvwa1ot 509 20 Parmyxoviridae Parmyxoviridae NNP cord-018437-yjvwa1ot 509 21 Polyomaviruses Polyomaviruses NNP cord-018437-yjvwa1ot 509 22 and and CC cord-018437-yjvwa1ot 509 23 human human JJ cord-018437-yjvwa1ot 509 24 cancer cancer NN cord-018437-yjvwa1ot 509 25 : : : cord-018437-yjvwa1ot 509 26 molecular molecular JJ cord-018437-yjvwa1ot 509 27 mechanisms mechanism NNS cord-018437-yjvwa1ot 509 28 underlying underlie VBG cord-018437-yjvwa1ot 509 29 patterns pattern NNS cord-018437-yjvwa1ot 509 30 of of IN cord-018437-yjvwa1ot 509 31 tumerogenesis tumerogenesis NN cord-018437-yjvwa1ot 509 32 Towards towards IN cord-018437-yjvwa1ot 509 33 a a DT cord-018437-yjvwa1ot 509 34 natural natural JJ cord-018437-yjvwa1ot 509 35 system system NN cord-018437-yjvwa1ot 509 36 of of IN cord-018437-yjvwa1ot 509 37 organisms organism NNS cord-018437-yjvwa1ot 509 38 : : : cord-018437-yjvwa1ot 509 39 proposal proposal NN cord-018437-yjvwa1ot 509 40 for for IN cord-018437-yjvwa1ot 509 41 the the DT cord-018437-yjvwa1ot 509 42 domains domain NNS cord-018437-yjvwa1ot 509 43 archaea archaea NNS cord-018437-yjvwa1ot 509 44 , , , cord-018437-yjvwa1ot 509 45 bacteria bacteria NNS cord-018437-yjvwa1ot 509 46 and and CC cord-018437-yjvwa1ot 509 47 eucarya eucarya NNP cord-018437-yjvwa1ot 509 48 A a DT cord-018437-yjvwa1ot 509 49 reevaluation reevaluation NN cord-018437-yjvwa1ot 509 50 of of IN cord-018437-yjvwa1ot 509 51 the the DT cord-018437-yjvwa1ot 509 52 higher high JJR cord-018437-yjvwa1ot 509 53 taxonomy taxonomy NN cord-018437-yjvwa1ot 509 54 of of IN cord-018437-yjvwa1ot 509 55 viruses virus NNS cord-018437-yjvwa1ot 509 56 based base VBN cord-018437-yjvwa1ot 509 57 on on IN cord-018437-yjvwa1ot 509 58 RNA RNA NNP cord-018437-yjvwa1ot 509 59 polymerases polymerase NNS cord-018437-yjvwa1ot 509 60 Papillomavirus Papillomavirus NNP cord-018437-yjvwa1ot 509 61 genome genome NN cord-018437-yjvwa1ot 509 62 structure structure NN cord-018437-yjvwa1ot 509 63 , , , cord-018437-yjvwa1ot 509 64 expression expression NN cord-018437-yjvwa1ot 509 65 , , , cord-018437-yjvwa1ot 509 66 and and CC cord-018437-yjvwa1ot 509 67 post post JJ cord-018437-yjvwa1ot 509 68 - - JJ cord-018437-yjvwa1ot 509 69 transcriptional transcriptional JJ cord-018437-yjvwa1ot 509 70 regulation regulation NN cord-018437-yjvwa1ot 509 71 Construction construction NN cord-018437-yjvwa1ot 509 72 and and CC cord-018437-yjvwa1ot 509 73 sequencing sequencing NN cord-018437-yjvwa1ot 509 74 of of IN cord-018437-yjvwa1ot 509 75 an an DT cord-018437-yjvwa1ot 509 76 infectious infectious JJ cord-018437-yjvwa1ot 509 77 clone clone NN cord-018437-yjvwa1ot 509 78 of of IN cord-018437-yjvwa1ot 509 79 the the DT cord-018437-yjvwa1ot 509 80 human human JJ cord-018437-yjvwa1ot 509 81 parvovirus parvovirus NN cord-018437-yjvwa1ot 509 82 B19 B19 NNP