id	sid	tid	token	lemma	pos
cord-016808-gy8d8285	1	1	key	key	JJ
cord-016808-gy8d8285	1	2	:	:	:
cord-016808-gy8d8285	1	3	cord-016808-gy8d8285	cord-016808-gy8d8285	JJ
cord-016808-gy8d8285	1	4	authors	author	NNS
cord-016808-gy8d8285	1	5	:	:	:
cord-016808-gy8d8285	2	1	Agol	Agol	NNP
cord-016808-gy8d8285	2	2	,	,	,
cord-016808-gy8d8285	2	3	Vadim	Vadim	NNP
cord-016808-gy8d8285	2	4	I.	I.	NNP
cord-016808-gy8d8285	2	5	title	title	NN
cord-016808-gy8d8285	2	6	:	:	:
cord-016808-gy8d8285	3	1	The	the	DT
cord-016808-gy8d8285	3	2	Origin	Origin	NNP
cord-016808-gy8d8285	3	3	and	and	CC
cord-016808-gy8d8285	3	4	Evolution	Evolution	NNP
cord-016808-gy8d8285	3	5	of	of	IN
cord-016808-gy8d8285	3	6	Viruses	virus	NNS
cord-016808-gy8d8285	3	7	date	date	NN
cord-016808-gy8d8285	3	8	:	:	:
cord-016808-gy8d8285	3	9	2008	2008	CD
cord-016808-gy8d8285	3	10	journal	journal	NN
cord-016808-gy8d8285	3	11	:	:	:
cord-016808-gy8d8285	3	12	Evolution	evolution	NN
cord-016808-gy8d8285	3	13	from	from	IN
cord-016808-gy8d8285	3	14	Cellular	Cellular	NNP
cord-016808-gy8d8285	3	15	to	to	IN
cord-016808-gy8d8285	3	16	Social	Social	NNP
cord-016808-gy8d8285	3	17	Scales	Scales	NNP
cord-016808-gy8d8285	3	18	DOI	DOI	NNP
cord-016808-gy8d8285	3	19	:	:	:
cord-016808-gy8d8285	3	20	10.1007/978	10.1007/978	CD
cord-016808-gy8d8285	3	21	-	-	HYPH
cord-016808-gy8d8285	3	22	1	1	CD
cord-016808-gy8d8285	3	23	-	-	HYPH
cord-016808-gy8d8285	3	24	4020	4020	CD
cord-016808-gy8d8285	3	25	-	-	HYPH
cord-016808-gy8d8285	3	26	8761	8761	CD
cord-016808-gy8d8285	3	27	-	-	HYPH
cord-016808-gy8d8285	3	28	5_7	5_7	CD
cord-016808-gy8d8285	3	29	sha	sha	NNP
cord-016808-gy8d8285	3	30	:	:	:
cord-016808-gy8d8285	3	31	146cde561d25d0dd4d014066152cf2103ec8be82	146cde561d25d0dd4d014066152cf2103ec8be82	CD
cord-016808-gy8d8285	3	32	doc_id	doc_id	CD
cord-016808-gy8d8285	3	33	:	:	:
cord-016808-gy8d8285	3	34	16808	16808	CD
cord-016808-gy8d8285	3	35	cord_uid	cord_uid	NNS
cord-016808-gy8d8285	3	36	:	:	:
cord-016808-gy8d8285	4	1	gy8d8285	gy8d8285	NNP
cord-016808-gy8d8285	5	1	The	the	DT
cord-016808-gy8d8285	5	2	lecture	lecture	NN
cord-016808-gy8d8285	5	3	covers	cover	VBZ
cord-016808-gy8d8285	5	4	three	three	CD
cord-016808-gy8d8285	5	5	main	main	JJ
cord-016808-gy8d8285	5	6	topics	topic	NNS
cord-016808-gy8d8285	5	7	:	:	:
cord-016808-gy8d8285	5	8	(	(	-LRB-
cord-016808-gy8d8285	5	9	i	i	NN
cord-016808-gy8d8285	5	10	)	)	-RRB-
cord-016808-gy8d8285	5	11	Viruses	virus	NNS
cord-016808-gy8d8285	5	12	:	:	:
cord-016808-gy8d8285	5	13	properties	property	NNS
cord-016808-gy8d8285	5	14	,	,	,
cord-016808-gy8d8285	5	15	place	place	VB
cord-016808-gy8d8285	5	16	in	in	IN
cord-016808-gy8d8285	5	17	the	the	DT
cord-016808-gy8d8285	5	18	living	live	VBG
cord-016808-gy8d8285	5	19	world	world	NN
cord-016808-gy8d8285	5	20	,	,	,
cord-016808-gy8d8285	5	21	and	and	CC
cord-016808-gy8d8285	5	22	possible	possible	JJ
cord-016808-gy8d8285	5	23	origin	origin	NN
cord-016808-gy8d8285	5	24	;	;	,
cord-016808-gy8d8285	5	25	(	(	-LRB-
cord-016808-gy8d8285	5	26	ii	ii	NN
cord-016808-gy8d8285	5	27	)	)	-RRB-
cord-016808-gy8d8285	5	28	Molecular	molecular	JJ
cord-016808-gy8d8285	5	29	basis	basis	NN
cord-016808-gy8d8285	5	30	of	of	IN
cord-016808-gy8d8285	5	31	viral	viral	JJ
cord-016808-gy8d8285	5	32	variability	variability	NN
cord-016808-gy8d8285	5	33	and	and	CC
cord-016808-gy8d8285	5	34	evolution	evolution	NN
cord-016808-gy8d8285	5	35	;	;	,
cord-016808-gy8d8285	5	36	and	and	CC
cord-016808-gy8d8285	5	37	(	(	-LRB-
cord-016808-gy8d8285	5	38	iii	iii	NN
cord-016808-gy8d8285	5	39	)	)	-RRB-
cord-016808-gy8d8285	5	40	Evolution	evolution	NN
cord-016808-gy8d8285	5	41	of	of	IN
cord-016808-gy8d8285	5	42	viral	viral	JJ
cord-016808-gy8d8285	5	43	pathogenicity	pathogenicity	NN
cord-016808-gy8d8285	5	44	and	and	CC
cord-016808-gy8d8285	5	45	emerging	emerge	VBG
cord-016808-gy8d8285	5	46	viral	viral	JJ
cord-016808-gy8d8285	5	47	infections	infection	NNS
cord-016808-gy8d8285	5	48	.	.	.
cord-016808-gy8d8285	6	1	or	or	CC
cord-016808-gy8d8285	6	2	circular	circular	JJ
cord-016808-gy8d8285	6	3	structures	structure	NNS
cord-016808-gy8d8285	6	4	.	.	.
cord-016808-gy8d8285	7	1	The	the	DT
cord-016808-gy8d8285	7	2	number	number	NN
cord-016808-gy8d8285	7	3	of	of	IN
cord-016808-gy8d8285	7	4	viral	viral	JJ
cord-016808-gy8d8285	7	5	genes	gene	NNS
cord-016808-gy8d8285	7	6	may	may	MD
cord-016808-gy8d8285	7	7	vary	vary	VB
cord-016808-gy8d8285	7	8	from	from	IN
cord-016808-gy8d8285	7	9	one	one	CD
cord-016808-gy8d8285	7	10	(	(	-LRB-
cord-016808-gy8d8285	7	11	e.g.	e.g.	RB
cord-016808-gy8d8285	7	12	,	,	,
cord-016808-gy8d8285	7	13	in	in	IN
cord-016808-gy8d8285	7	14	hepatitis	hepatitis	NNP
cord-016808-gy8d8285	7	15	delta	delta	NNP
cord-016808-gy8d8285	7	16	virus	virus	NN
cord-016808-gy8d8285	7	17	)	)	-RRB-
cord-016808-gy8d8285	7	18	to	to	IN
cord-016808-gy8d8285	7	19	∼1,200	∼1,200	NNP
cord-016808-gy8d8285	7	20	(	(	-LRB-
cord-016808-gy8d8285	7	21	in	in	IN
cord-016808-gy8d8285	7	22	mimivirus	mimivirus	NNP
cord-016808-gy8d8285	7	23	)	)	-RRB-
cord-016808-gy8d8285	7	24	.	.	.
cord-016808-gy8d8285	8	1	In	in	IN
cord-016808-gy8d8285	8	2	the	the	DT
cord-016808-gy8d8285	8	3	latter	latter	JJ
cord-016808-gy8d8285	8	4	case	case	NN
cord-016808-gy8d8285	8	5	,	,	,
cord-016808-gy8d8285	8	6	the	the	DT
cord-016808-gy8d8285	8	7	size	size	NN
cord-016808-gy8d8285	8	8	of	of	IN
cord-016808-gy8d8285	8	9	the	the	DT
cord-016808-gy8d8285	8	10	viral	viral	JJ
cord-016808-gy8d8285	8	11	genome	genome	NN
cord-016808-gy8d8285	8	12	is	be	VBZ
cord-016808-gy8d8285	8	13	several	several	JJ
cord-016808-gy8d8285	8	14	-	-	HYPH
cord-016808-gy8d8285	8	15	fold	fold	VB
cord-016808-gy8d8285	8	16	larger	large	JJR
cord-016808-gy8d8285	8	17	than	than	IN
cord-016808-gy8d8285	8	18	that	that	DT
cord-016808-gy8d8285	8	19	in	in	IN
cord-016808-gy8d8285	8	20	the	the	DT
cord-016808-gy8d8285	8	21	smallest	small	JJS
cord-016808-gy8d8285	8	22	cellular	cellular	JJ
cord-016808-gy8d8285	8	23	organisms	organism	NNS
cord-016808-gy8d8285	8	24	.	.	.
cord-016808-gy8d8285	9	1	A	a	DT
cord-016808-gy8d8285	9	2	distinctive	distinctive	JJ
cord-016808-gy8d8285	9	3	property	property	NN
cord-016808-gy8d8285	9	4	of	of	IN
cord-016808-gy8d8285	9	5	viruses	virus	NNS
cord-016808-gy8d8285	9	6	is	be	VBZ
cord-016808-gy8d8285	9	7	the	the	DT
cord-016808-gy8d8285	9	8	absence	absence	NN
cord-016808-gy8d8285	9	9	of	of	IN
cord-016808-gy8d8285	9	10	protein	protein	NN
cord-016808-gy8d8285	9	11	-	-	HYPH
cord-016808-gy8d8285	9	12	synthesizing	synthesize	VBG
cord-016808-gy8d8285	9	13	and	and	CC
cord-016808-gy8d8285	9	14	energy	energy	NN
cord-016808-gy8d8285	9	15	-	-	HYPH
cord-016808-gy8d8285	9	16	generating	generate	VBG
cord-016808-gy8d8285	9	17	machineries	machinery	NNS
cord-016808-gy8d8285	9	18	.	.	.
cord-016808-gy8d8285	10	1	As	as	IN
cord-016808-gy8d8285	10	2	a	a	DT
cord-016808-gy8d8285	10	3	result	result	NN
cord-016808-gy8d8285	10	4	,	,	,
cord-016808-gy8d8285	10	5	viruses	virus	NNS
cord-016808-gy8d8285	10	6	are	be	VBP
cord-016808-gy8d8285	10	7	strictly	strictly	RB
cord-016808-gy8d8285	10	8	dependent	dependent	JJ
cord-016808-gy8d8285	10	9	on	on	IN
cord-016808-gy8d8285	10	10	the	the	DT
cord-016808-gy8d8285	10	11	host	host	NN
cord-016808-gy8d8285	10	12	cell	cell	NN
cord-016808-gy8d8285	10	13	.	.	.
cord-016808-gy8d8285	11	1	Another	another	DT
cord-016808-gy8d8285	11	2	fundamental	fundamental	JJ
cord-016808-gy8d8285	11	3	distinction	distinction	NN
cord-016808-gy8d8285	11	4	between	between	IN
cord-016808-gy8d8285	11	5	viruses	virus	NNS
cord-016808-gy8d8285	11	6	and	and	CC
cord-016808-gy8d8285	11	7	cells	cell	NNS
cord-016808-gy8d8285	11	8	is	be	VBZ
cord-016808-gy8d8285	11	9	the	the	DT
cord-016808-gy8d8285	11	10	mode	mode	NN
cord-016808-gy8d8285	11	11	of	of	IN
cord-016808-gy8d8285	11	12	their	-PRON-	PRP$
cord-016808-gy8d8285	11	13	multiplication	multiplication	NN
cord-016808-gy8d8285	11	14	.	.	.
cord-016808-gy8d8285	12	1	Viral	viral	JJ
cord-016808-gy8d8285	12	2	reproduction	reproduction	NN
cord-016808-gy8d8285	12	3	is	be	VBZ
cord-016808-gy8d8285	12	4	based	base	VBN
cord-016808-gy8d8285	12	5	on	on	IN
cord-016808-gy8d8285	12	6	disjunctive	disjunctive	JJ
cord-016808-gy8d8285	12	7	mechanisms	mechanism	NNS
cord-016808-gy8d8285	12	8	,	,	,
cord-016808-gy8d8285	12	9	whereupon	whereupon	WRB
cord-016808-gy8d8285	12	10	virus	virus	NN
cord-016808-gy8d8285	12	11	-	-	HYPH
cord-016808-gy8d8285	12	12	specific	specific	JJ
cord-016808-gy8d8285	12	13	proteins	protein	NNS
cord-016808-gy8d8285	12	14	and	and	CC
cord-016808-gy8d8285	12	15	genomic	genomic	JJ
cord-016808-gy8d8285	12	16	nucleic	nucleic	JJ
cord-016808-gy8d8285	12	17	acids	acid	NNS
cord-016808-gy8d8285	12	18	are	be	VBP
cord-016808-gy8d8285	12	19	accumulated	accumulate	VBN
cord-016808-gy8d8285	12	20	as	as	IN
cord-016808-gy8d8285	12	21	separate	separate	JJ
cord-016808-gy8d8285	12	22	pools	pool	NNS
cord-016808-gy8d8285	12	23	,	,	,
cord-016808-gy8d8285	12	24	from	from	IN
cord-016808-gy8d8285	12	25	which	which	WDT
cord-016808-gy8d8285	12	26	multiple	multiple	JJ
cord-016808-gy8d8285	12	27	mature	mature	JJ
cord-016808-gy8d8285	12	28	progeny	progeny	JJ
cord-016808-gy8d8285	12	29	viral	viral	JJ
cord-016808-gy8d8285	12	30	particles	particle	NNS
cord-016808-gy8d8285	12	31	(	(	-LRB-
cord-016808-gy8d8285	12	32	or	or	CC
cord-016808-gy8d8285	12	33	their	-PRON-	PRP$
cord-016808-gy8d8285	12	34	core	core	NN
cord-016808-gy8d8285	12	35	nucleoproteins	nucleoprotein	NNS
cord-016808-gy8d8285	12	36	)	)	-RRB-
cord-016808-gy8d8285	12	37	are	be	VBP
cord-016808-gy8d8285	12	38	eventually	eventually	RB
cord-016808-gy8d8285	12	39	assembled	assemble	VBN
cord-016808-gy8d8285	12	40	.	.	.
cord-016808-gy8d8285	13	1	On	on	IN
cord-016808-gy8d8285	13	2	the	the	DT
cord-016808-gy8d8285	13	3	other	other	JJ
cord-016808-gy8d8285	13	4	hand	hand	NN
cord-016808-gy8d8285	13	5	,	,	,
cord-016808-gy8d8285	13	6	cellular	cellular	JJ
cord-016808-gy8d8285	13	7	multiplication	multiplication	NN
cord-016808-gy8d8285	13	8	involves	involve	VBZ
cord-016808-gy8d8285	13	9	(	(	-LRB-
cord-016808-gy8d8285	13	10	usually	usually	RB
cord-016808-gy8d8285	13	11	binary	binary	JJ
cord-016808-gy8d8285	13	12	)	)	-RRB-
cord-016808-gy8d8285	13	13	division	division	NN
cord-016808-gy8d8285	13	14	.	.	.
cord-016808-gy8d8285	14	1	During	during	IN
cord-016808-gy8d8285	14	2	a	a	DT
cord-016808-gy8d8285	14	3	part	part	NN
cord-016808-gy8d8285	14	4	of	of	IN
cord-016808-gy8d8285	14	5	their	-PRON-	PRP$
cord-016808-gy8d8285	14	6	life	life	NN
cord-016808-gy8d8285	14	7	cycle	cycle	NN
cord-016808-gy8d8285	14	8	,	,	,
cord-016808-gy8d8285	14	9	the	the	DT
cord-016808-gy8d8285	14	10	genome	genome	NN
cord-016808-gy8d8285	14	11	of	of	IN
cord-016808-gy8d8285	14	12	some	some	DT
cord-016808-gy8d8285	14	13	viruses	virus	NNS
cord-016808-gy8d8285	14	14	may	may	MD
cord-016808-gy8d8285	14	15	be	be	VB
cord-016808-gy8d8285	14	16	integrated	integrate	VBN
cord-016808-gy8d8285	14	17	into	into	IN
cord-016808-gy8d8285	14	18	the	the	DT
cord-016808-gy8d8285	14	19	host	host	NN
cord-016808-gy8d8285	14	20	cell	cell	NN
cord-016808-gy8d8285	14	21	genome	genome	NN
cord-016808-gy8d8285	14	22	,	,	,
cord-016808-gy8d8285	14	23	existing	exist	VBG
cord-016808-gy8d8285	14	24	and	and	CC
cord-016808-gy8d8285	14	25	dividing	divide	VBG
cord-016808-gy8d8285	14	26	as	as	IN
cord-016808-gy8d8285	14	27	a	a	DT
cord-016808-gy8d8285	14	28	cellular	cellular	JJ
cord-016808-gy8d8285	14	29	chromosomal	chromosomal	JJ
cord-016808-gy8d8285	14	30	segment	segment	NN
cord-016808-gy8d8285	14	31	.	.	.
cord-016808-gy8d8285	15	1	Depending	depend	VBG
cord-016808-gy8d8285	15	2	on	on	IN
cord-016808-gy8d8285	15	3	the	the	DT
cord-016808-gy8d8285	15	4	type	type	NN
cord-016808-gy8d8285	15	5	of	of	IN
cord-016808-gy8d8285	15	6	genome	genome	NN
cord-016808-gy8d8285	15	7	and	and	CC
cord-016808-gy8d8285	15	8	mechanisms	mechanism	NNS
cord-016808-gy8d8285	15	9	of	of	IN
cord-016808-gy8d8285	15	10	its	-PRON-	PRP$
cord-016808-gy8d8285	15	11	replication	replication	NN
cord-016808-gy8d8285	15	12	and	and	CC
cord-016808-gy8d8285	15	13	expression	expression	NN
cord-016808-gy8d8285	15	14	,	,	,
cord-016808-gy8d8285	15	15	several	several	JJ
cord-016808-gy8d8285	15	16	major	major	JJ
cord-016808-gy8d8285	15	17	types	type	NNS
cord-016808-gy8d8285	15	18	of	of	IN
cord-016808-gy8d8285	15	19	viral	viral	JJ
cord-016808-gy8d8285	15	20	"	"	``
cord-016808-gy8d8285	15	21	strategies	strategy	NNS
cord-016808-gy8d8285	15	22	"	"	''
cord-016808-gy8d8285	15	23	can	can	MD
cord-016808-gy8d8285	15	24	be	be	VB
cord-016808-gy8d8285	15	25	discerned	discern	VBN
cord-016808-gy8d8285	15	26	(	(	-LRB-
cord-016808-gy8d8285	15	27	Baltimore	Baltimore	NNP
cord-016808-gy8d8285	15	28	,	,	,
cord-016808-gy8d8285	15	29	1971	1971	CD
cord-016808-gy8d8285	15	30	;	;	:
cord-016808-gy8d8285	15	31	Agol	Agol	NNP
cord-016808-gy8d8285	15	32	,	,	,
cord-016808-gy8d8285	15	33	1974	1974	CD
cord-016808-gy8d8285	15	34	)	)	-RRB-
cord-016808-gy8d8285	15	35	.	.	.
cord-016808-gy8d8285	16	1	Remarkably	remarkably	RB
cord-016808-gy8d8285	16	2	,	,	,
cord-016808-gy8d8285	16	3	all	all	PDT
cord-016808-gy8d8285	16	4	the	the	DT
cord-016808-gy8d8285	16	5	theoretically	theoretically	RB
cord-016808-gy8d8285	16	6	possible	possible	JJ
cord-016808-gy8d8285	16	7	replication	replication	NN
cord-016808-gy8d8285	16	8	/	/	SYM
cord-016808-gy8d8285	16	9	transcription	transcription	NN
cord-016808-gy8d8285	16	10	systems	system	NNS
cord-016808-gy8d8285	16	11	based	base	VBN
cord-016808-gy8d8285	16	12	on	on	IN
cord-016808-gy8d8285	16	13	the	the	DT
cord-016808-gy8d8285	16	14	principle	principle	NN
cord-016808-gy8d8285	16	15	of	of	IN
cord-016808-gy8d8285	16	16	complementarity	complementarity	NN
cord-016808-gy8d8285	16	17	appear	appear	VBP
cord-016808-gy8d8285	16	18	to	to	TO
cord-016808-gy8d8285	16	19	be	be	VB
cord-016808-gy8d8285	16	20	exploited	exploit	VBN
cord-016808-gy8d8285	16	21	by	by	IN
cord-016808-gy8d8285	16	22	viruses	virus	NNS
cord-016808-gy8d8285	16	23	.	.	.
cord-016808-gy8d8285	17	1	The	the	DT
cord-016808-gy8d8285	17	2	replication	replication	NN
cord-016808-gy8d8285	17	3	/	/	SYM
cord-016808-gy8d8285	17	4	transcription	transcription	NN
cord-016808-gy8d8285	17	5	system	system	NN
cord-016808-gy8d8285	17	6	used	use	VBN
cord-016808-gy8d8285	17	7	by	by	IN
cord-016808-gy8d8285	17	8	genomes	genome	NNS
cord-016808-gy8d8285	17	9	of	of	IN
cord-016808-gy8d8285	17	10	cellular	cellular	JJ
cord-016808-gy8d8285	17	11	organisms	organism	NNS
cord-016808-gy8d8285	17	12	comprises	comprise	VBZ
cord-016808-gy8d8285	17	13	only	only	RB
cord-016808-gy8d8285	17	14	a	a	DT
cord-016808-gy8d8285	17	15	minor	minor	JJ
cord-016808-gy8d8285	17	16	subset	subset	NN
cord-016808-gy8d8285	17	17	of	of	IN
cord-016808-gy8d8285	17	18	the	the	DT
cord-016808-gy8d8285	17	19	systems	system	NNS
cord-016808-gy8d8285	17	20	exploited	exploit	VBN
cord-016808-gy8d8285	17	21	by	by	IN
cord-016808-gy8d8285	17	22	viruses	virus	NNS
cord-016808-gy8d8285	17	23	.	.	.
cord-016808-gy8d8285	18	1	Viruses	virus	NNS
cord-016808-gy8d8285	18	2	have	have	VBP
cord-016808-gy8d8285	18	3	very	very	RB
cord-016808-gy8d8285	18	4	close	close	JJ
cord-016808-gy8d8285	18	5	relatives	relative	NNS
cord-016808-gy8d8285	18	6	,	,	,
cord-016808-gy8d8285	18	7	selfish	selfish	JJ
cord-016808-gy8d8285	18	8	genetic	genetic	JJ
cord-016808-gy8d8285	18	9	elements	element	NNS
cord-016808-gy8d8285	18	10	(	(	-LRB-
cord-016808-gy8d8285	18	11	DNA	DNA	NNP
cord-016808-gy8d8285	18	12	or	or	CC
cord-016808-gy8d8285	18	13	RNA	RNA	NNP
cord-016808-gy8d8285	18	14	)	)	-RRB-
cord-016808-gy8d8285	18	15	:	:	:
cord-016808-gy8d8285	18	16	viroids	viroids	NNP
cord-016808-gy8d8285	18	17	(	(	-LRB-
cord-016808-gy8d8285	18	18	small	small	JJ
cord-016808-gy8d8285	18	19	infectious	infectious	JJ
cord-016808-gy8d8285	18	20	non	non	JJ
cord-016808-gy8d8285	18	21	-	-	JJ
cord-016808-gy8d8285	18	22	coding	coding	JJ
cord-016808-gy8d8285	18	23	circular	circular	JJ
cord-016808-gy8d8285	18	24	RNA	RNA	NNP
cord-016808-gy8d8285	18	25	)	)	-RRB-
cord-016808-gy8d8285	18	26	,	,	,
cord-016808-gy8d8285	18	27	plasmids	plasmid	NNS
cord-016808-gy8d8285	18	28	(	(	-LRB-
cord-016808-gy8d8285	18	29	various	various	JJ
cord-016808-gy8d8285	18	30	nonchromosomal	nonchromosomal	JJ
cord-016808-gy8d8285	18	31	DNA	DNA	NNP
cord-016808-gy8d8285	18	32	or	or	CC
cord-016808-gy8d8285	18	33	RNA	RNA	NNP
cord-016808-gy8d8285	18	34	elements	element	NNS
cord-016808-gy8d8285	18	35	)	)	-RRB-
cord-016808-gy8d8285	18	36	,	,	,
cord-016808-gy8d8285	18	37	transposons	transposon	NNS
cord-016808-gy8d8285	18	38	(	(	-LRB-
cord-016808-gy8d8285	18	39	DNA	dna	NN
cord-016808-gy8d8285	18	40	elements	element	NNS
cord-016808-gy8d8285	18	41	moving	move	VBG
cord-016808-gy8d8285	18	42	between	between	IN
cord-016808-gy8d8285	18	43	different	different	JJ
cord-016808-gy8d8285	18	44	positions	position	NNS
cord-016808-gy8d8285	18	45	of	of	IN
cord-016808-gy8d8285	18	46	a	a	DT
cord-016808-gy8d8285	18	47	genome	genome	NN
cord-016808-gy8d8285	18	48	;	;	:
cord-016808-gy8d8285	18	49	mobile	mobile	JJ
cord-016808-gy8d8285	18	50	genetic	genetic	JJ
cord-016808-gy8d8285	18	51	elements	element	NNS
cord-016808-gy8d8285	18	52	)	)	-RRB-
cord-016808-gy8d8285	18	53	,	,	,
cord-016808-gy8d8285	18	54	retrotransposons	retrotransposon	NNS
cord-016808-gy8d8285	18	55	(	(	-LRB-
cord-016808-gy8d8285	18	56	mobile	mobile	JJ
cord-016808-gy8d8285	18	57	DNA	dna	NN
cord-016808-gy8d8285	18	58	elements	element	NNS
cord-016808-gy8d8285	18	59	exploiting	exploit	VBG
cord-016808-gy8d8285	18	60	reverse	reverse	JJ
cord-016808-gy8d8285	18	61	transcription	transcription	NN
cord-016808-gy8d8285	18	62	)	)	-RRB-
cord-016808-gy8d8285	18	63	and	and	CC
cord-016808-gy8d8285	18	64	some	some	DT
cord-016808-gy8d8285	18	65	others	other	NNS
cord-016808-gy8d8285	18	66	.	.	.
cord-016808-gy8d8285	19	1	Viruses	virus	NNS
cord-016808-gy8d8285	19	2	alike	alike	RB
cord-016808-gy8d8285	19	3	,	,	,
cord-016808-gy8d8285	19	4	they	-PRON-	PRP
cord-016808-gy8d8285	19	5	are	be	VBP
cord-016808-gy8d8285	19	6	fully	fully	RB
cord-016808-gy8d8285	19	7	dependent	dependent	JJ
cord-016808-gy8d8285	19	8	on	on	IN
cord-016808-gy8d8285	19	9	cellular	cellular	JJ
cord-016808-gy8d8285	19	10	translation	translation	NN
cord-016808-gy8d8285	19	11	and	and	CC
cord-016808-gy8d8285	19	12	energy	energy	NN
cord-016808-gy8d8285	19	13	-	-	HYPH
cord-016808-gy8d8285	19	14	generating	generate	VBG
cord-016808-gy8d8285	19	15	machineries	machinery	NNS
cord-016808-gy8d8285	19	16	and	and	CC
cord-016808-gy8d8285	19	17	use	use	VB
cord-016808-gy8d8285	19	18	the	the	DT
cord-016808-gy8d8285	19	19	same	same	JJ
cord-016808-gy8d8285	19	20	expression	expression	NN
cord-016808-gy8d8285	19	21	and	and	CC
cord-016808-gy8d8285	19	22	replication	replication	NN
cord-016808-gy8d8285	19	23	mechanisms	mechanism	NNS
cord-016808-gy8d8285	19	24	as	as	IN
cord-016808-gy8d8285	19	25	viruses	virus	NNS
cord-016808-gy8d8285	19	26	do	do	VBP
cord-016808-gy8d8285	19	27	.	.	.
cord-016808-gy8d8285	20	1	They	-PRON-	PRP
cord-016808-gy8d8285	20	2	may	may	MD
cord-016808-gy8d8285	20	3	be	be	VB
cord-016808-gy8d8285	20	4	integrated	integrate	VBN
cord-016808-gy8d8285	20	5	into	into	IN
cord-016808-gy8d8285	20	6	cellular	cellular	JJ
cord-016808-gy8d8285	20	7	DNA	DNA	NNP
cord-016808-gy8d8285	20	8	or	or	CC
cord-016808-gy8d8285	20	9	RNA	RNA	NNP
cord-016808-gy8d8285	20	10	or	or	CC
cord-016808-gy8d8285	20	11	exist	exist	VBP
cord-016808-gy8d8285	20	12	separately	separately	RB
cord-016808-gy8d8285	20	13	,	,	,
cord-016808-gy8d8285	20	14	may	may	MD
cord-016808-gy8d8285	20	15	be	be	VB
cord-016808-gy8d8285	20	16	amplified	amplify	VBN
cord-016808-gy8d8285	20	17	in	in	IN
cord-016808-gy8d8285	20	18	a	a	DT
cord-016808-gy8d8285	20	19	cell	cell	NN
cord-016808-gy8d8285	20	20	,	,	,
cord-016808-gy8d8285	20	21	move	move	VB
cord-016808-gy8d8285	20	22	between	between	IN
cord-016808-gy8d8285	20	23	different	different	JJ
cord-016808-gy8d8285	20	24	parts	part	NNS
cord-016808-gy8d8285	20	25	of	of	IN
cord-016808-gy8d8285	20	26	the	the	DT
cord-016808-gy8d8285	20	27	genetic	genetic	JJ
cord-016808-gy8d8285	20	28	material	material	NN
cord-016808-gy8d8285	20	29	of	of	IN
cord-016808-gy8d8285	20	30	a	a	DT
cord-016808-gy8d8285	20	31	cells	cell	NNS
cord-016808-gy8d8285	20	32	or	or	CC
cord-016808-gy8d8285	20	33	migrate	migrate	VBP
cord-016808-gy8d8285	20	34	between	between	IN
cord-016808-gy8d8285	20	35	cells	cell	NNS
cord-016808-gy8d8285	20	36	.	.	.
cord-016808-gy8d8285	21	1	Therefore	therefore	RB
cord-016808-gy8d8285	21	2	,	,	,
cord-016808-gy8d8285	21	3	these	these	DT
cord-016808-gy8d8285	21	4	elements	element	NNS
cord-016808-gy8d8285	21	5	can	can	MD
cord-016808-gy8d8285	21	6	be	be	VB
cord-016808-gy8d8285	21	7	combined	combine	VBN
cord-016808-gy8d8285	21	8	with	with	IN
cord-016808-gy8d8285	21	9	viruses	virus	NNS
cord-016808-gy8d8285	21	10	into	into	IN
cord-016808-gy8d8285	21	11	a	a	DT
cord-016808-gy8d8285	21	12	common	common	JJ
cord-016808-gy8d8285	21	13	domain	domain	NN
cord-016808-gy8d8285	21	14	of	of	IN
cord-016808-gy8d8285	21	15	life	life	NN
cord-016808-gy8d8285	21	16	.	.	.
cord-016808-gy8d8285	22	1	In	in	IN
cord-016808-gy8d8285	22	2	distinction	distinction	NN
cord-016808-gy8d8285	22	3	from	from	IN
cord-016808-gy8d8285	22	4	viruses	virus	NNS
cord-016808-gy8d8285	22	5	,	,	,
cord-016808-gy8d8285	22	6	however	however	RB
cord-016808-gy8d8285	22	7	,	,	,
cord-016808-gy8d8285	22	8	they	-PRON-	PRP
cord-016808-gy8d8285	22	9	lack	lack	VBP
cord-016808-gy8d8285	22	10	protein	protein	NN
cord-016808-gy8d8285	22	11	coats	coat	NNS
cord-016808-gy8d8285	22	12	and	and	CC
cord-016808-gy8d8285	22	13	stable	stable	JJ
cord-016808-gy8d8285	22	14	extracellular	extracellular	JJ
cord-016808-gy8d8285	22	15	forms	form	NNS
cord-016808-gy8d8285	22	16	.	.	.
cord-016808-gy8d8285	23	1	There	there	EX
cord-016808-gy8d8285	23	2	are	be	VBP
cord-016808-gy8d8285	23	3	two	two	CD
cord-016808-gy8d8285	23	4	major	major	JJ
cord-016808-gy8d8285	23	5	problems	problem	NNS
cord-016808-gy8d8285	23	6	related	relate	VBN
cord-016808-gy8d8285	23	7	to	to	IN
cord-016808-gy8d8285	23	8	the	the	DT
cord-016808-gy8d8285	23	9	origin	origin	NN
cord-016808-gy8d8285	23	10	of	of	IN
cord-016808-gy8d8285	23	11	viruses	virus	NNS
cord-016808-gy8d8285	23	12	.	.	.
cord-016808-gy8d8285	24	1	What	what	WP
cord-016808-gy8d8285	24	2	are	be	VBP
cord-016808-gy8d8285	24	3	relationships	relationship	NNS
cord-016808-gy8d8285	24	4	between	between	IN
cord-016808-gy8d8285	24	5	viruses	virus	NNS
cord-016808-gy8d8285	24	6	and	and	CC
cord-016808-gy8d8285	24	7	cellular	cellular	JJ
cord-016808-gy8d8285	24	8	organisms	organism	NNS
cord-016808-gy8d8285	24	9	?	?	.
cord-016808-gy8d8285	25	1	In	in	IN
cord-016808-gy8d8285	25	2	other	other	JJ
cord-016808-gy8d8285	25	3	words	word	NNS
cord-016808-gy8d8285	25	4	,	,	,
cord-016808-gy8d8285	25	5	is	be	VBZ
cord-016808-gy8d8285	25	6	there	there	EX
cord-016808-gy8d8285	25	7	a	a	DT
cord-016808-gy8d8285	25	8	place(s	place(s	NN
cord-016808-gy8d8285	25	9	)	)	-RRB-
cord-016808-gy8d8285	25	10	for	for	IN
cord-016808-gy8d8285	25	11	viruses	virus	NNS
cord-016808-gy8d8285	25	12	on	on	IN
cord-016808-gy8d8285	25	13	universal	universal	JJ
cord-016808-gy8d8285	25	14	trees	tree	NNS
cord-016808-gy8d8285	25	15	of	of	IN
cord-016808-gy8d8285	25	16	life	life	NN
cord-016808-gy8d8285	25	17	proposed	propose	VBN
cord-016808-gy8d8285	25	18	for	for	IN
cord-016808-gy8d8285	25	19	its	-PRON-	PRP$
cord-016808-gy8d8285	25	20	three	three	CD
cord-016808-gy8d8285	25	21	kingdoms	kingdom	NNS
cord-016808-gy8d8285	25	22	,	,	,
cord-016808-gy8d8285	25	23	Archea	Archea	NNP
cord-016808-gy8d8285	25	24	,	,	,
cord-016808-gy8d8285	25	25	Eubacteria	Eubacteria	NNP
cord-016808-gy8d8285	25	26	,	,	,
cord-016808-gy8d8285	25	27	and	and	CC
cord-016808-gy8d8285	25	28	Eukarya	Eukarya	NNP
cord-016808-gy8d8285	25	29	?	?	.
cord-016808-gy8d8285	26	1	And	and	CC
cord-016808-gy8d8285	26	2	secondly	secondly	RB
cord-016808-gy8d8285	26	3	,	,	,
cord-016808-gy8d8285	26	4	are	be	VBP
cord-016808-gy8d8285	26	5	viruses	virus	NNS
cord-016808-gy8d8285	26	6	monophyletic	monophyletic	JJ
cord-016808-gy8d8285	27	1	,	,	,
cord-016808-gy8d8285	27	2	i.e.	i.e.	FW
cord-016808-gy8d8285	27	3	,	,	,
cord-016808-gy8d8285	27	4	is	be	VBZ
cord-016808-gy8d8285	27	5	there	there	EX
cord-016808-gy8d8285	27	6	a	a	DT
cord-016808-gy8d8285	27	7	single	single	JJ
cord-016808-gy8d8285	27	8	evolutionary	evolutionary	JJ
cord-016808-gy8d8285	27	9	tree	tree	NN
cord-016808-gy8d8285	27	10	or	or	CC
cord-016808-gy8d8285	27	11	branch	branch	NN
cord-016808-gy8d8285	27	12	of	of	IN
cord-016808-gy8d8285	27	13	viruses	virus	NNS
cord-016808-gy8d8285	27	14	?	?	.
cord-016808-gy8d8285	28	1	During	during	IN
cord-016808-gy8d8285	28	2	the	the	DT
cord-016808-gy8d8285	28	3	first	first	JJ
cord-016808-gy8d8285	28	4	century	century	NN
cord-016808-gy8d8285	28	5	after	after	IN
cord-016808-gy8d8285	28	6	discovery	discovery	NN
cord-016808-gy8d8285	28	7	of	of	IN
cord-016808-gy8d8285	28	8	viruses	virus	NNS
cord-016808-gy8d8285	28	9	,	,	,
cord-016808-gy8d8285	28	10	several	several	JJ
cord-016808-gy8d8285	28	11	purely	purely	RB
cord-016808-gy8d8285	28	12	speculative	speculative	JJ
cord-016808-gy8d8285	28	13	but	but	CC
cord-016808-gy8d8285	28	14	quite	quite	RB
cord-016808-gy8d8285	28	15	imaginative	imaginative	JJ
cord-016808-gy8d8285	28	16	hypotheses	hypothesis	NNS
cord-016808-gy8d8285	28	17	had	have	VBD
cord-016808-gy8d8285	28	18	been	be	VBN
cord-016808-gy8d8285	28	19	proposed	propose	VBN
cord-016808-gy8d8285	28	20	:	:	:
cord-016808-gy8d8285	28	21	according	accord	VBG
cord-016808-gy8d8285	28	22	to	to	IN
cord-016808-gy8d8285	28	23	them	-PRON-	PRP
cord-016808-gy8d8285	28	24	,	,	,
cord-016808-gy8d8285	28	25	viruses	virus	NNS
cord-016808-gy8d8285	28	26	originated	originate	VBD
cord-016808-gy8d8285	28	27	from	from	IN
cord-016808-gy8d8285	28	28	escaped	escape	VBD
cord-016808-gy8d8285	28	29	(	(	-LRB-
cord-016808-gy8d8285	28	30	"	"	``
cord-016808-gy8d8285	28	31	mad	mad	JJ
cord-016808-gy8d8285	28	32	"	"	''
cord-016808-gy8d8285	28	33	)	)	-RRB-
cord-016808-gy8d8285	29	1	cellular	cellular	JJ
cord-016808-gy8d8285	29	2	genes	gene	NNS
cord-016808-gy8d8285	29	3	,	,	,
cord-016808-gy8d8285	29	4	or	or	CC
cord-016808-gy8d8285	29	5	from	from	IN
cord-016808-gy8d8285	29	6	degenerated	degenerated	JJ
cord-016808-gy8d8285	29	7	cells	cell	NNS
cord-016808-gy8d8285	29	8	,	,	,
cord-016808-gy8d8285	29	9	or	or	CC
cord-016808-gy8d8285	29	10	they	-PRON-	PRP
cord-016808-gy8d8285	29	11	are	be	VBP
cord-016808-gy8d8285	29	12	descendants	descendant	NNS
cord-016808-gy8d8285	29	13	of	of	IN
cord-016808-gy8d8285	29	14	precellular	precellular	JJ
cord-016808-gy8d8285	29	15	genetic	genetic	JJ
cord-016808-gy8d8285	29	16	elements	element	NNS
cord-016808-gy8d8285	29	17	.	.	.
cord-016808-gy8d8285	30	1	Modern	modern	JJ
cord-016808-gy8d8285	30	2	hypotheses	hypothesis	NNS
cord-016808-gy8d8285	30	3	of	of	IN
cord-016808-gy8d8285	30	4	viral	viral	JJ
cord-016808-gy8d8285	30	5	origin	origin	NN
cord-016808-gy8d8285	30	6	are	be	VBP
cord-016808-gy8d8285	30	7	based	base	VBN
cord-016808-gy8d8285	30	8	on	on	IN
cord-016808-gy8d8285	30	9	two	two	CD
cord-016808-gy8d8285	30	10	major	major	JJ
cord-016808-gy8d8285	30	11	developments	development	NNS
cord-016808-gy8d8285	30	12	of	of	IN
cord-016808-gy8d8285	30	13	the	the	DT
cord-016808-gy8d8285	30	14	molecular	molecular	JJ
cord-016808-gy8d8285	30	15	biology	biology	NN
cord-016808-gy8d8285	30	16	:	:	:
cord-016808-gy8d8285	30	17	discovery	discovery	NN
cord-016808-gy8d8285	30	18	of	of	IN
cord-016808-gy8d8285	30	19	ribozymes	ribozyme	NNS
cord-016808-gy8d8285	30	20	(	(	-LRB-
cord-016808-gy8d8285	30	21	RNA	RNA	NNP
cord-016808-gy8d8285	30	22	-	-	HYPH
cord-016808-gy8d8285	30	23	based	base	VBN
cord-016808-gy8d8285	30	24	enzymes	enzyme	NNS
cord-016808-gy8d8285	30	25	)	)	-RRB-
cord-016808-gy8d8285	30	26	and	and	CC
cord-016808-gy8d8285	30	27	formulation	formulation	NN
cord-016808-gy8d8285	30	28	of	of	IN
cord-016808-gy8d8285	30	29	the	the	DT
cord-016808-gy8d8285	30	30	"	"	``
cord-016808-gy8d8285	30	31	RNA	RNA	NNP
cord-016808-gy8d8285	30	32	World	World	NNP
cord-016808-gy8d8285	30	33	"	"	''
cord-016808-gy8d8285	30	34	theory	theory	NN
cord-016808-gy8d8285	30	35	(	(	-LRB-
cord-016808-gy8d8285	30	36	RNA	RNA	NNP
cord-016808-gy8d8285	30	37	had	have	VBD
cord-016808-gy8d8285	30	38	been	be	VBN
cord-016808-gy8d8285	30	39	"	"	``
cord-016808-gy8d8285	30	40	invented	invent	VBN
cord-016808-gy8d8285	30	41	"	"	''
cord-016808-gy8d8285	30	42	before	before	IN
cord-016808-gy8d8285	30	43	proteins	protein	NNS
cord-016808-gy8d8285	30	44	and	and	CC
cord-016808-gy8d8285	30	45	DNA	DNA	NNP
cord-016808-gy8d8285	30	46	)	)	-RRB-
cord-016808-gy8d8285	30	47	,	,	,
cord-016808-gy8d8285	30	48	on	on	IN
cord-016808-gy8d8285	30	49	the	the	DT
cord-016808-gy8d8285	30	50	one	one	CD
cord-016808-gy8d8285	30	51	hand	hand	NN
cord-016808-gy8d8285	30	52	,	,	,
cord-016808-gy8d8285	30	53	and	and	CC
cord-016808-gy8d8285	30	54	achievements	achievement	NNS
cord-016808-gy8d8285	30	55	of	of	IN
cord-016808-gy8d8285	30	56	genomics	genomic	NNS
cord-016808-gy8d8285	30	57	(	(	-LRB-
cord-016808-gy8d8285	30	58	determination	determination	NN
cord-016808-gy8d8285	30	59	of	of	IN
cord-016808-gy8d8285	30	60	the	the	DT
cord-016808-gy8d8285	30	61	nucleotide	nucleotide	JJ
cord-016808-gy8d8285	30	62	sequences	sequence	NNS
cord-016808-gy8d8285	30	63	of	of	IN
cord-016808-gy8d8285	30	64	a	a	DT
cord-016808-gy8d8285	30	65	great	great	JJ
cord-016808-gy8d8285	30	66	number	number	NN
cord-016808-gy8d8285	30	67	of	of	IN
cord-016808-gy8d8285	30	68	cellular	cellular	JJ
cord-016808-gy8d8285	30	69	and	and	CC
cord-016808-gy8d8285	30	70	viral	viral	JJ
cord-016808-gy8d8285	30	71	genomes	genome	NNS
cord-016808-gy8d8285	30	72	)	)	-RRB-
cord-016808-gy8d8285	30	73	,	,	,
cord-016808-gy8d8285	30	74	on	on	IN
cord-016808-gy8d8285	30	75	the	the	DT
cord-016808-gy8d8285	30	76	other	other	JJ
cord-016808-gy8d8285	30	77	.	.	.
cord-016808-gy8d8285	31	1	These	these	DT
cord-016808-gy8d8285	31	2	hypotheses	hypothesis	NNS
cord-016808-gy8d8285	31	3	postulate	postulate	VBP
cord-016808-gy8d8285	31	4	a	a	DT
cord-016808-gy8d8285	31	5	very	very	RB
cord-016808-gy8d8285	31	6	significant	significant	JJ
cord-016808-gy8d8285	31	7	contribution	contribution	NN
cord-016808-gy8d8285	31	8	of	of	IN
cord-016808-gy8d8285	31	9	viruses	virus	NNS
cord-016808-gy8d8285	31	10	to	to	IN
cord-016808-gy8d8285	31	11	the	the	DT
cord-016808-gy8d8285	31	12	genetic	genetic	JJ
cord-016808-gy8d8285	31	13	information	information	NN
cord-016808-gy8d8285	31	14	of	of	IN
cord-016808-gy8d8285	31	15	cellular	cellular	JJ
cord-016808-gy8d8285	31	16	organisms	organism	NNS
cord-016808-gy8d8285	31	17	.	.	.
cord-016808-gy8d8285	32	1	According	accord	VBG
cord-016808-gy8d8285	32	2	to	to	IN
cord-016808-gy8d8285	32	3	the	the	DT
cord-016808-gy8d8285	32	4	"	"	``
cord-016808-gy8d8285	32	5	Three	three	CD
cord-016808-gy8d8285	32	6	viruses	virus	NNS
cord-016808-gy8d8285	32	7	,	,	,
cord-016808-gy8d8285	32	8	three	three	CD
cord-016808-gy8d8285	32	9	domains	domain	NNS
cord-016808-gy8d8285	32	10	"	"	''
cord-016808-gy8d8285	32	11	hypothesis	hypothesis	NN
cord-016808-gy8d8285	32	12	proposed	propose	VBN
cord-016808-gy8d8285	32	13	by	by	IN
cord-016808-gy8d8285	32	14	P.	P.	NNP
cord-016808-gy8d8285	32	15	Forterre	Forterre	NNP
cord-016808-gy8d8285	32	16	,	,	,
cord-016808-gy8d8285	32	17	the	the	DT
cord-016808-gy8d8285	32	18	cellular	cellular	JJ
cord-016808-gy8d8285	32	19	Last	Last	NNP
cord-016808-gy8d8285	32	20	Universal	Universal	NNP
cord-016808-gy8d8285	32	21	Common	Common	NNP
cord-016808-gy8d8285	32	22	Ancestor	Ancestor	NNP
cord-016808-gy8d8285	32	23	(	(	-LRB-
cord-016808-gy8d8285	32	24	LUCA	LUCA	NNP
cord-016808-gy8d8285	32	25	)	)	-RRB-
cord-016808-gy8d8285	32	26	had	have	VBD
cord-016808-gy8d8285	32	27	an	an	DT
cord-016808-gy8d8285	32	28	RNA	RNA	NNP
cord-016808-gy8d8285	32	29	genome	genome	NN
cord-016808-gy8d8285	32	30	and	and	CC
cord-016808-gy8d8285	32	31	harbored	harbor	VBD
cord-016808-gy8d8285	32	32	a	a	DT
cord-016808-gy8d8285	32	33	variety	variety	NN
cord-016808-gy8d8285	32	34	of	of	IN
cord-016808-gy8d8285	32	35	already	already	RB
cord-016808-gy8d8285	32	36	created	create	VBN
cord-016808-gy8d8285	32	37	RNA	RNA	NNP
cord-016808-gy8d8285	32	38	-	-	HYPH
cord-016808-gy8d8285	32	39	containing	contain	VBG
cord-016808-gy8d8285	32	40	viruses	virus	NNS
cord-016808-gy8d8285	32	41	.	.	.
cord-016808-gy8d8285	33	1	During	during	IN
cord-016808-gy8d8285	33	2	the	the	DT
cord-016808-gy8d8285	33	3	next	next	JJ
cord-016808-gy8d8285	33	4	step	step	NN
cord-016808-gy8d8285	33	5	,	,	,
cord-016808-gy8d8285	33	6	DNA	dna	NN
cord-016808-gy8d8285	33	7	and	and	CC
cord-016808-gy8d8285	33	8	DNA	dna	NN
cord-016808-gy8d8285	33	9	viruses	virus	NNS
cord-016808-gy8d8285	33	10	had	have	VBD
cord-016808-gy8d8285	33	11	been	be	VBN
cord-016808-gy8d8285	33	12	invented	invent	VBN
cord-016808-gy8d8285	33	13	.	.	.
cord-016808-gy8d8285	34	1	Three	three	CD
cord-016808-gy8d8285	34	2	distinct	distinct	JJ
cord-016808-gy8d8285	34	3	DNA	dna	NN
cord-016808-gy8d8285	34	4	viruses	virus	NNS
cord-016808-gy8d8285	34	5	,	,	,
cord-016808-gy8d8285	34	6	which	which	WDT
cord-016808-gy8d8285	34	7	had	have	VBD
cord-016808-gy8d8285	34	8	infected	infect	VBN
cord-016808-gy8d8285	34	9	RNA	RNA	NNP
cord-016808-gy8d8285	34	10	genome	genome	NN
cord-016808-gy8d8285	34	11	-	-	HYPH
cord-016808-gy8d8285	34	12	containing	contain	VBG
cord-016808-gy8d8285	34	13	cells	cell	NNS
cord-016808-gy8d8285	34	14	,	,	,
cord-016808-gy8d8285	34	15	gave	give	VBD
cord-016808-gy8d8285	34	16	rise	rise	NN
cord-016808-gy8d8285	34	17	to	to	IN
cord-016808-gy8d8285	34	18	the	the	DT
cord-016808-gy8d8285	34	19	three	three	CD
cord-016808-gy8d8285	34	20	distinct	distinct	JJ
cord-016808-gy8d8285	34	21	domains	domain	NNS
cord-016808-gy8d8285	34	22	of	of	IN
cord-016808-gy8d8285	34	23	life	life	NN
cord-016808-gy8d8285	34	24	,	,	,
cord-016808-gy8d8285	34	25	bacteria	bacteria	NNS
cord-016808-gy8d8285	34	26	,	,	,
cord-016808-gy8d8285	34	27	archea	archea	NNP
cord-016808-gy8d8285	34	28	,	,	,
cord-016808-gy8d8285	34	29	and	and	CC
cord-016808-gy8d8285	34	30	eukarya	eukarya	NNP
cord-016808-gy8d8285	34	31	(	(	-LRB-
cord-016808-gy8d8285	34	32	Forterre	Forterre	NNP
cord-016808-gy8d8285	34	33	,	,	,
cord-016808-gy8d8285	34	34	2006	2006	CD
cord-016808-gy8d8285	34	35	)	)	-RRB-
cord-016808-gy8d8285	34	36	.	.	.
cord-016808-gy8d8285	35	1	A	a	DT
cord-016808-gy8d8285	35	2	detailed	detailed	JJ
cord-016808-gy8d8285	35	3	hypothetical	hypothetical	JJ
cord-016808-gy8d8285	35	4	evolutionary	evolutionary	JJ
cord-016808-gy8d8285	35	5	scenario	scenario	NN
cord-016808-gy8d8285	35	6	was	be	VBD
cord-016808-gy8d8285	35	7	described	describe	VBN
cord-016808-gy8d8285	35	8	by	by	IN
cord-016808-gy8d8285	35	9	E.	E.	NNP
cord-016808-gy8d8285	35	10	Koonin	Koonin	NNP
cord-016808-gy8d8285	35	11	and	and	CC
cord-016808-gy8d8285	35	12	colleagues	colleague	NNS
cord-016808-gy8d8285	35	13	(	(	-LRB-
cord-016808-gy8d8285	35	14	Koonin	Koonin	NNP
cord-016808-gy8d8285	35	15	and	and	CC
cord-016808-gy8d8285	35	16	Martin	Martin	NNP
cord-016808-gy8d8285	35	17	,	,	,
cord-016808-gy8d8285	35	18	2005	2005	CD
cord-016808-gy8d8285	35	19	;	;	:
cord-016808-gy8d8285	35	20	Koonin	Koonin	NNP
cord-016808-gy8d8285	35	21	et	et	NNP
cord-016808-gy8d8285	35	22	al	al	NNP
cord-016808-gy8d8285	35	23	.	.	NNP
cord-016808-gy8d8285	35	24	,	,	,
cord-016808-gy8d8285	35	25	2006	2006	CD
cord-016808-gy8d8285	35	26	)	)	-RRB-
cord-016808-gy8d8285	35	27	.	.	.
cord-016808-gy8d8285	36	1	The	the	DT
cord-016808-gy8d8285	36	2	authors	author	NNS
cord-016808-gy8d8285	36	3	suggest	suggest	VBP
cord-016808-gy8d8285	36	4	that	that	IN
cord-016808-gy8d8285	36	5	life	life	NN
cord-016808-gy8d8285	36	6	has	have	VBZ
cord-016808-gy8d8285	36	7	originated	originate	VBN
cord-016808-gy8d8285	36	8	in	in	IN
cord-016808-gy8d8285	36	9	inorganic	inorganic	JJ
cord-016808-gy8d8285	36	10	compartments	compartment	NNS
cord-016808-gy8d8285	36	11	serving	serve	VBG
cord-016808-gy8d8285	36	12	as	as	IN
cord-016808-gy8d8285	36	13	surrogate	surrogate	JJ
cord-016808-gy8d8285	36	14	cells	cell	NNS
cord-016808-gy8d8285	36	15	.	.	.
cord-016808-gy8d8285	37	1	RNA	rna	NN
cord-016808-gy8d8285	37	2	molecules	molecule	NNS
cord-016808-gy8d8285	37	3	with	with	IN
cord-016808-gy8d8285	37	4	enzymatic	enzymatic	JJ
cord-016808-gy8d8285	37	5	activities	activity	NNS
cord-016808-gy8d8285	37	6	(	(	-LRB-
cord-016808-gy8d8285	38	1	ribozymes	ribozyme	NNS
cord-016808-gy8d8285	38	2	)	)	-RRB-
cord-016808-gy8d8285	38	3	could	could	MD
cord-016808-gy8d8285	38	4	attain	attain	VB
cord-016808-gy8d8285	38	5	there	there	EX
cord-016808-gy8d8285	38	6	relatively	relatively	RB
cord-016808-gy8d8285	38	7	high	high	JJ
cord-016808-gy8d8285	38	8	concentrations	concentration	NNS
cord-016808-gy8d8285	38	9	and	and	CC
cord-016808-gy8d8285	38	10	could	could	MD
cord-016808-gy8d8285	38	11	move	move	VB
cord-016808-gy8d8285	38	12	between	between	IN
cord-016808-gy8d8285	38	13	compartments	compartment	NNS
cord-016808-gy8d8285	38	14	and	and	CC
cord-016808-gy8d8285	38	15	"	"	``
cord-016808-gy8d8285	38	16	infect	infect	VB
cord-016808-gy8d8285	38	17	"	"	''
cord-016808-gy8d8285	38	18	them	-PRON-	PRP
cord-016808-gy8d8285	38	19	.	.	.
cord-016808-gy8d8285	39	1	At	at	IN
cord-016808-gy8d8285	39	2	this	this	DT
cord-016808-gy8d8285	39	3	precellular	precellular	JJ
cord-016808-gy8d8285	39	4	stage	stage	NN
cord-016808-gy8d8285	39	5	,	,	,
cord-016808-gy8d8285	39	6	several	several	JJ
cord-016808-gy8d8285	39	7	fundamental	fundamental	JJ
cord-016808-gy8d8285	39	8	inventions	invention	NNS
cord-016808-gy8d8285	39	9	had	have	VBD
cord-016808-gy8d8285	39	10	been	be	VBN
cord-016808-gy8d8285	39	11	consecutively	consecutively	RB
cord-016808-gy8d8285	39	12	made	make	VBN
cord-016808-gy8d8285	39	13	.	.	.
cord-016808-gy8d8285	40	1	The	the	DT
cord-016808-gy8d8285	40	2	invention	invention	NN
cord-016808-gy8d8285	40	3	of	of	IN
cord-016808-gy8d8285	40	4	proteins	protein	NNS
cord-016808-gy8d8285	40	5	led	lead	VBN
cord-016808-gy8d8285	40	6	to	to	IN
cord-016808-gy8d8285	40	7	the	the	DT
cord-016808-gy8d8285	40	8	appearance	appearance	NN
cord-016808-gy8d8285	40	9	of	of	IN
cord-016808-gy8d8285	40	10	viruses	virus	NNS
cord-016808-gy8d8285	40	11	with	with	IN
cord-016808-gy8d8285	40	12	positive	positive	JJ
cord-016808-gy8d8285	40	13	single	single	JJ
cord-016808-gy8d8285	40	14	-	-	HYPH
cord-016808-gy8d8285	40	15	strand	strand	NN
cord-016808-gy8d8285	40	16	and	and	CC
cord-016808-gy8d8285	40	17	with	with	IN
cord-016808-gy8d8285	40	18	double	double	JJ
cord-016808-gy8d8285	40	19	-	-	HYPH
cord-016808-gy8d8285	40	20	strand	strand	NN
cord-016808-gy8d8285	40	21	RNA	RNA	NNP
cord-016808-gy8d8285	40	22	genomes	genome	NNS
cord-016808-gy8d8285	40	23	.	.	.
cord-016808-gy8d8285	41	1	The	the	DT
cord-016808-gy8d8285	41	2	invention	invention	NN
cord-016808-gy8d8285	41	3	of	of	IN
cord-016808-gy8d8285	41	4	DNA	dna	NN
cord-016808-gy8d8285	41	5	resulting	result	VBG
cord-016808-gy8d8285	41	6	from	from	IN
cord-016808-gy8d8285	41	7	RNA	rna	NN
cord-016808-gy8d8285	41	8	-	-	HYPH
cord-016808-gy8d8285	41	9	dependent	dependent	JJ
cord-016808-gy8d8285	41	10	DNA	dna	NN
cord-016808-gy8d8285	41	11	synthesis	synthesis	NN
cord-016808-gy8d8285	41	12	led	lead	VBD
cord-016808-gy8d8285	41	13	to	to	IN
cord-016808-gy8d8285	41	14	the	the	DT
cord-016808-gy8d8285	41	15	appearance	appearance	NN
cord-016808-gy8d8285	41	16	of	of	IN
cord-016808-gy8d8285	41	17	retroviruses	retrovirus	NNS
cord-016808-gy8d8285	41	18	,	,	,
cord-016808-gy8d8285	41	19	retroid	retroid	NNP
cord-016808-gy8d8285	41	20	viruses	virus	NNS
cord-016808-gy8d8285	41	21	and	and	CC
cord-016808-gy8d8285	41	22	retroposons	retroposon	NNS
cord-016808-gy8d8285	41	23	.	.	.
cord-016808-gy8d8285	42	1	Finally	finally	RB
cord-016808-gy8d8285	42	2	,	,	,
cord-016808-gy8d8285	42	3	DNA	dna	NN
cord-016808-gy8d8285	42	4	-	-	HYPH
cord-016808-gy8d8285	42	5	dependent	dependent	JJ
cord-016808-gy8d8285	42	6	DNA	dna	NN
cord-016808-gy8d8285	42	7	synthesis	synthesis	NN
cord-016808-gy8d8285	42	8	had	have	VBD
cord-016808-gy8d8285	42	9	been	be	VBN
cord-016808-gy8d8285	42	10	invented	invent	VBN
cord-016808-gy8d8285	42	11	,	,	,
cord-016808-gy8d8285	42	12	giving	give	VBG
cord-016808-gy8d8285	42	13	rise	rise	NN
cord-016808-gy8d8285	42	14	to	to	IN
cord-016808-gy8d8285	42	15	the	the	DT
cord-016808-gy8d8285	42	16	appearance	appearance	NN
cord-016808-gy8d8285	42	17	of	of	IN
cord-016808-gy8d8285	42	18	viruses	virus	NNS
cord-016808-gy8d8285	42	19	with	with	IN
cord-016808-gy8d8285	42	20	double	double	JJ
cord-016808-gy8d8285	42	21	-	-	HYPH
cord-016808-gy8d8285	42	22	strand	strand	NN
cord-016808-gy8d8285	42	23	DNA	dna	NN
cord-016808-gy8d8285	42	24	genomes	genome	NNS
cord-016808-gy8d8285	42	25	and	and	CC
cord-016808-gy8d8285	42	26	DNA	dna	NN
cord-016808-gy8d8285	42	27	plasmids	plasmid	NNS
cord-016808-gy8d8285	42	28	.	.	.
cord-016808-gy8d8285	43	1	Only	only	RB
cord-016808-gy8d8285	43	2	after	after	IN
cord-016808-gy8d8285	43	3	achieving	achieve	VBG
cord-016808-gy8d8285	43	4	such	such	JJ
cord-016808-gy8d8285	43	5	genetic	genetic	JJ
cord-016808-gy8d8285	43	6	variability	variability	NN
cord-016808-gy8d8285	43	7	and	and	CC
cord-016808-gy8d8285	43	8	richness	richness	NN
cord-016808-gy8d8285	43	9	,	,	,
cord-016808-gy8d8285	43	10	the	the	DT
cord-016808-gy8d8285	43	11	"	"	``
cord-016808-gy8d8285	43	12	pre	pre	JJ
cord-016808-gy8d8285	43	13	-	-	JJ
cord-016808-gy8d8285	43	14	archeal	archeal	JJ
cord-016808-gy8d8285	43	15	"	"	''
cord-016808-gy8d8285	43	16	and	and	CC
cord-016808-gy8d8285	43	17	"	"	``
cord-016808-gy8d8285	43	18	pre	pre	JJ
cord-016808-gy8d8285	43	19	-	-	JJ
cord-016808-gy8d8285	43	20	bacterial	bacterial	JJ
cord-016808-gy8d8285	43	21	"	"	''
cord-016808-gy8d8285	43	22	inorganic	inorganic	JJ
cord-016808-gy8d8285	43	23	compartments	compartment	NNS
cord-016808-gy8d8285	43	24	had	have	VBD
cord-016808-gy8d8285	43	25	been	be	VBN
cord-016808-gy8d8285	43	26	replaced	replace	VBN
cord-016808-gy8d8285	43	27	by	by	IN
cord-016808-gy8d8285	43	28	cellular	cellular	JJ
cord-016808-gy8d8285	43	29	forms	form	NNS
cord-016808-gy8d8285	43	30	,	,	,
cord-016808-gy8d8285	43	31	which	which	WDT
cord-016808-gy8d8285	43	32	retained	retain	VBD
cord-016808-gy8d8285	43	33	numerous	numerous	JJ
cord-016808-gy8d8285	43	34	ancient	ancient	JJ
cord-016808-gy8d8285	43	35	viruses	virus	NNS
cord-016808-gy8d8285	43	36	.	.	.
cord-016808-gy8d8285	44	1	The	the	DT
cord-016808-gy8d8285	44	2	engulfment	engulfment	NN
cord-016808-gy8d8285	44	3	of	of	IN
cord-016808-gy8d8285	44	4	a	a	DT
cord-016808-gy8d8285	44	5	bacterium	bacterium	NN
cord-016808-gy8d8285	44	6	by	by	IN
cord-016808-gy8d8285	44	7	an	an	DT
cord-016808-gy8d8285	44	8	archaeon	archaeon	NN
cord-016808-gy8d8285	44	9	was	be	VBD
cord-016808-gy8d8285	44	10	the	the	DT
cord-016808-gy8d8285	44	11	starting	starting	NN
cord-016808-gy8d8285	44	12	point	point	NN
cord-016808-gy8d8285	44	13	of	of	IN
cord-016808-gy8d8285	44	14	eukarya	eukarya	NNP
cord-016808-gy8d8285	44	15	,	,	,
cord-016808-gy8d8285	44	16	which	which	WDT
cord-016808-gy8d8285	44	17	acquired	acquire	VBD
cord-016808-gy8d8285	44	18	viruses	virus	NNS
cord-016808-gy8d8285	44	19	of	of	IN
cord-016808-gy8d8285	44	20	both	both	DT
cord-016808-gy8d8285	44	21	of	of	IN
cord-016808-gy8d8285	44	22	their	-PRON-	PRP$
cord-016808-gy8d8285	44	23	"	"	``
cord-016808-gy8d8285	44	24	parents	parent	NNS
cord-016808-gy8d8285	44	25	"	"	''
cord-016808-gy8d8285	44	26	.	.	.
cord-016808-gy8d8285	45	1	According	accord	VBG
cord-016808-gy8d8285	45	2	to	to	IN
cord-016808-gy8d8285	45	3	Koonin	Koonin	NNP
cord-016808-gy8d8285	45	4	,	,	,
cord-016808-gy8d8285	45	5	the	the	DT
cord-016808-gy8d8285	45	6	major	major	JJ
cord-016808-gy8d8285	45	7	classes	class	NNS
cord-016808-gy8d8285	45	8	of	of	IN
cord-016808-gy8d8285	45	9	viruses	virus	NNS
cord-016808-gy8d8285	45	10	do	do	VBP
cord-016808-gy8d8285	45	11	not	not	RB
cord-016808-gy8d8285	45	12	have	have	VB
cord-016808-gy8d8285	45	13	a	a	DT
cord-016808-gy8d8285	45	14	common	common	JJ
cord-016808-gy8d8285	45	15	origin	origin	NN
cord-016808-gy8d8285	45	16	in	in	IN
cord-016808-gy8d8285	45	17	the	the	DT
cord-016808-gy8d8285	45	18	traditional	traditional	JJ
cord-016808-gy8d8285	45	19	sense	sense	NN
cord-016808-gy8d8285	45	20	but	but	CC
cord-016808-gy8d8285	45	21	neither	neither	DT
cord-016808-gy8d8285	45	22	are	be	VBP
cord-016808-gy8d8285	45	23	they	-PRON-	PRP
cord-016808-gy8d8285	45	24	unrelated	unrelated	JJ
cord-016808-gy8d8285	45	25	.	.	.
cord-016808-gy8d8285	46	1	On	on	IN
cord-016808-gy8d8285	46	2	the	the	DT
cord-016808-gy8d8285	46	3	other	other	JJ
cord-016808-gy8d8285	46	4	hand	hand	NN
cord-016808-gy8d8285	46	5	,	,	,
cord-016808-gy8d8285	46	6	a	a	DT
cord-016808-gy8d8285	46	7	very	very	RB
cord-016808-gy8d8285	46	8	significant	significant	JJ
cord-016808-gy8d8285	46	9	proportion	proportion	NN
cord-016808-gy8d8285	46	10	of	of	IN
cord-016808-gy8d8285	46	11	the	the	DT
cord-016808-gy8d8285	46	12	cellular	cellular	JJ
cord-016808-gy8d8285	46	13	genetic	genetic	JJ
cord-016808-gy8d8285	46	14	material	material	NN
cord-016808-gy8d8285	46	15	has	have	VBZ
cord-016808-gy8d8285	46	16	evolutionary	evolutionary	JJ
cord-016808-gy8d8285	46	17	relatedness	relatedness	NN
cord-016808-gy8d8285	46	18	to	to	IN
cord-016808-gy8d8285	46	19	the	the	DT
cord-016808-gy8d8285	46	20	genetic	genetic	JJ
cord-016808-gy8d8285	46	21	composition	composition	NN
cord-016808-gy8d8285	46	22	of	of	IN
cord-016808-gy8d8285	46	23	the	the	DT
cord-016808-gy8d8285	46	24	ancient	ancient	JJ
cord-016808-gy8d8285	46	25	world	world	NN
cord-016808-gy8d8285	46	26	of	of	IN
cord-016808-gy8d8285	46	27	RNA	RNA	NNP
cord-016808-gy8d8285	46	28	viruses	virus	NNS
cord-016808-gy8d8285	46	29	.	.	.
cord-016808-gy8d8285	47	1	It	-PRON-	PRP
cord-016808-gy8d8285	47	2	is	be	VBZ
cord-016808-gy8d8285	47	3	estimated	estimate	VBN
cord-016808-gy8d8285	47	4	that	that	IN
cord-016808-gy8d8285	47	5	well	well	RB
cord-016808-gy8d8285	47	6	over	over	IN
cord-016808-gy8d8285	47	7	a	a	DT
cord-016808-gy8d8285	47	8	half	half	NN
cord-016808-gy8d8285	47	9	of	of	IN
cord-016808-gy8d8285	47	10	mammalian	mammalian	JJ
cord-016808-gy8d8285	47	11	genome	genome	NN
cord-016808-gy8d8285	47	12	is	be	VBZ
cord-016808-gy8d8285	47	13	inherited	inherit	VBN
cord-016808-gy8d8285	47	14	from	from	IN
cord-016808-gy8d8285	47	15	viruses	virus	NNS
cord-016808-gy8d8285	47	16	.	.	.
cord-016808-gy8d8285	48	1	In	in	IN
cord-016808-gy8d8285	48	2	other	other	JJ
cord-016808-gy8d8285	48	3	words	word	NNS
cord-016808-gy8d8285	48	4	,	,	,
cord-016808-gy8d8285	48	5	"	"	''
cord-016808-gy8d8285	48	6	the	the	DT
cord-016808-gy8d8285	48	7	tree	tree	NN
cord-016808-gy8d8285	48	8	of	of	IN
cord-016808-gy8d8285	48	9	life	life	NN
cord-016808-gy8d8285	48	10	and	and	CC
cord-016808-gy8d8285	48	11	its	-PRON-	PRP$
cord-016808-gy8d8285	48	12	root	root	NN
cord-016808-gy8d8285	48	13	are	be	VBP
cord-016808-gy8d8285	48	14	immersed	immerse	VBN
cord-016808-gy8d8285	48	15	in	in	IN
cord-016808-gy8d8285	48	16	a	a	DT
cord-016808-gy8d8285	48	17	viral	viral	JJ
cord-016808-gy8d8285	48	18	ocean	ocean	NN
cord-016808-gy8d8285	48	19	"	"	''
cord-016808-gy8d8285	48	20	(	(	-LRB-
cord-016808-gy8d8285	48	21	Bamford	Bamford	NNP
cord-016808-gy8d8285	48	22	,	,	,
cord-016808-gy8d8285	48	23	2003	2003	CD
cord-016808-gy8d8285	48	24	)	)	-RRB-
cord-016808-gy8d8285	48	25	.	.	.
cord-016808-gy8d8285	49	1	The	the	DT
cord-016808-gy8d8285	49	2	above	above	JJ
cord-016808-gy8d8285	49	3	scenarios	scenario	NNS
cord-016808-gy8d8285	49	4	also	also	RB
cord-016808-gy8d8285	49	5	suggest	suggest	VBP
cord-016808-gy8d8285	49	6	that	that	IN
cord-016808-gy8d8285	49	7	modern	modern	JJ
cord-016808-gy8d8285	49	8	viruses	virus	NNS
cord-016808-gy8d8285	49	9	have	have	VBP
cord-016808-gy8d8285	49	10	inherited	inherit	VBN
cord-016808-gy8d8285	49	11	molecular	molecular	JJ
cord-016808-gy8d8285	49	12	mechanisms	mechanism	NNS
cord-016808-gy8d8285	49	13	that	that	WDT
cord-016808-gy8d8285	49	14	have	have	VBP
cord-016808-gy8d8285	49	15	disappeared	disappear	VBN
cord-016808-gy8d8285	49	16	from	from	IN
cord-016808-gy8d8285	49	17	modern	modern	JJ
cord-016808-gy8d8285	49	18	DNA	dna	NN
cord-016808-gy8d8285	49	19	cells	cell	NNS
cord-016808-gy8d8285	49	20	.	.	.
cord-016808-gy8d8285	50	1	That	that	DT
cord-016808-gy8d8285	50	2	is	be	VBZ
cord-016808-gy8d8285	50	3	why	why	WRB
cord-016808-gy8d8285	50	4	transcription	transcription	NN
cord-016808-gy8d8285	50	5	and	and	CC
cord-016808-gy8d8285	50	6	replication	replication	NN
cord-016808-gy8d8285	50	7	mechanisms	mechanism	NNS
cord-016808-gy8d8285	50	8	in	in	IN
cord-016808-gy8d8285	50	9	the	the	DT
cord-016808-gy8d8285	50	10	viral	viral	JJ
cord-016808-gy8d8285	50	11	world	world	NN
cord-016808-gy8d8285	50	12	are	be	VBP
cord-016808-gy8d8285	50	13	more	more	RBR
cord-016808-gy8d8285	50	14	diverse	diverse	JJ
cord-016808-gy8d8285	50	15	than	than	IN
cord-016808-gy8d8285	50	16	those	those	DT
cord-016808-gy8d8285	50	17	in	in	IN
cord-016808-gy8d8285	50	18	the	the	DT
cord-016808-gy8d8285	50	19	cellular	cellular	JJ
cord-016808-gy8d8285	50	20	world	world	NN
cord-016808-gy8d8285	50	21	.	.	.
cord-016808-gy8d8285	51	1	It	-PRON-	PRP
cord-016808-gy8d8285	51	2	can	can	MD
cord-016808-gy8d8285	51	3	not	not	RB
cord-016808-gy8d8285	51	4	be	be	VB
cord-016808-gy8d8285	51	5	excluded	exclude	VBN
cord-016808-gy8d8285	51	6	that	that	IN
cord-016808-gy8d8285	51	7	many	many	JJ
cord-016808-gy8d8285	51	8	yet	yet	CC
cord-016808-gy8d8285	51	9	unknown	unknown	JJ
cord-016808-gy8d8285	51	10	molecular	molecular	JJ
cord-016808-gy8d8285	51	11	mechanisms	mechanism	NNS
cord-016808-gy8d8285	51	12	exist	exist	VBP
cord-016808-gy8d8285	51	13	in	in	IN
cord-016808-gy8d8285	51	14	the	the	DT
cord-016808-gy8d8285	51	15	current	current	JJ
cord-016808-gy8d8285	51	16	viral	viral	JJ
cord-016808-gy8d8285	51	17	world	world	NN
cord-016808-gy8d8285	51	18	.	.	.
cord-016808-gy8d8285	52	1	The	the	DT
cord-016808-gy8d8285	52	2	exploration	exploration	NN
cord-016808-gy8d8285	52	3	of	of	IN
cord-016808-gy8d8285	52	4	the	the	DT
cord-016808-gy8d8285	52	5	viral	viral	JJ
cord-016808-gy8d8285	52	6	diversity	diversity	NN
cord-016808-gy8d8285	52	7	is	be	VBZ
cord-016808-gy8d8285	52	8	one	one	CD
cord-016808-gy8d8285	52	9	of	of	IN
cord-016808-gy8d8285	52	10	the	the	DT
cord-016808-gy8d8285	52	11	major	major	JJ
cord-016808-gy8d8285	52	12	challenges	challenge	NNS
cord-016808-gy8d8285	52	13	of	of	IN
cord-016808-gy8d8285	52	14	biology	biology	NN
cord-016808-gy8d8285	52	15	in	in	IN
cord-016808-gy8d8285	52	16	this	this	DT
cord-016808-gy8d8285	52	17	century	century	NN
cord-016808-gy8d8285	52	18	.	.	.
cord-016808-gy8d8285	53	1	After	after	IN
cord-016808-gy8d8285	53	2	their	-PRON-	PRP$
cord-016808-gy8d8285	53	3	"	"	``
cord-016808-gy8d8285	53	4	birth	birth	NN
cord-016808-gy8d8285	53	5	"	"	''
cord-016808-gy8d8285	53	6	,	,	,
cord-016808-gy8d8285	53	7	viral	viral	JJ
cord-016808-gy8d8285	53	8	genomes	genome	NNS
cord-016808-gy8d8285	53	9	had	have	VBD
cord-016808-gy8d8285	53	10	been	be	VBN
cord-016808-gy8d8285	53	11	and	and	CC
cord-016808-gy8d8285	53	12	are	be	VBP
cord-016808-gy8d8285	53	13	still	still	RB
cord-016808-gy8d8285	53	14	evolving	evolve	VBG
cord-016808-gy8d8285	53	15	by	by	IN
cord-016808-gy8d8285	53	16	accumulation	accumulation	NN
cord-016808-gy8d8285	53	17	of	of	IN
cord-016808-gy8d8285	53	18	point	point	NN
cord-016808-gy8d8285	53	19	mutations	mutation	NNS
cord-016808-gy8d8285	53	20	and	and	CC
cord-016808-gy8d8285	53	21	genome	genome	NN
cord-016808-gy8d8285	53	22	rearrangements	rearrangement	NNS
cord-016808-gy8d8285	53	23	(	(	-LRB-
cord-016808-gy8d8285	53	24	duplications	duplication	NNS
cord-016808-gy8d8285	53	25	,	,	,
cord-016808-gy8d8285	53	26	deletions	deletion	NNS
cord-016808-gy8d8285	53	27	,	,	,
cord-016808-gy8d8285	53	28	recombination	recombination	NN
cord-016808-gy8d8285	53	29	)	)	-RRB-
cord-016808-gy8d8285	53	30	.	.	.
cord-016808-gy8d8285	54	1	The	the	DT
cord-016808-gy8d8285	54	2	frequency	frequency	NN
cord-016808-gy8d8285	54	3	of	of	IN
cord-016808-gy8d8285	54	4	mutations	mutation	NNS
cord-016808-gy8d8285	54	5	in	in	IN
cord-016808-gy8d8285	54	6	DNA	dna	NN
cord-016808-gy8d8285	54	7	viruses	virus	NNS
cord-016808-gy8d8285	54	8	may	may	MD
cord-016808-gy8d8285	54	9	be	be	VB
cord-016808-gy8d8285	54	10	several	several	JJ
cord-016808-gy8d8285	54	11	orders	order	NNS
cord-016808-gy8d8285	54	12	of	of	IN
cord-016808-gy8d8285	54	13	magnitude	magnitude	NN
cord-016808-gy8d8285	54	14	lower	low	JJR
cord-016808-gy8d8285	54	15	than	than	IN
cord-016808-gy8d8285	54	16	in	in	IN
cord-016808-gy8d8285	54	17	RNA	RNA	NNP
cord-016808-gy8d8285	54	18	viruses	virus	NNS
cord-016808-gy8d8285	54	19	,	,	,
cord-016808-gy8d8285	54	20	whose	whose	WP$
cord-016808-gy8d8285	54	21	replicative	replicative	JJ
cord-016808-gy8d8285	54	22	enzyme	enzyme	NN
cord-016808-gy8d8285	54	23	,	,	,
cord-016808-gy8d8285	54	24	the	the	DT
cord-016808-gy8d8285	54	25	RNA	RNA	NNP
cord-016808-gy8d8285	54	26	-	-	HYPH
cord-016808-gy8d8285	54	27	dependent	dependent	JJ
cord-016808-gy8d8285	54	28	RNA	RNA	NNP
cord-016808-gy8d8285	54	29	polymerase	polymerase	NN
cord-016808-gy8d8285	54	30	,	,	,
cord-016808-gy8d8285	54	31	lacks	lack	VBZ
cord-016808-gy8d8285	54	32	proof	proof	NN
cord-016808-gy8d8285	54	33	-	-	HYPH
cord-016808-gy8d8285	54	34	reading	read	VBG
cord-016808-gy8d8285	54	35	activity	activity	NN
cord-016808-gy8d8285	54	36	.	.	.
cord-016808-gy8d8285	55	1	The	the	DT
cord-016808-gy8d8285	55	2	error	error	NN
cord-016808-gy8d8285	55	3	frequency	frequency	NN
cord-016808-gy8d8285	55	4	in	in	IN
cord-016808-gy8d8285	55	5	RNA	RNA	NNP
cord-016808-gy8d8285	55	6	viruses	virus	NNS
cord-016808-gy8d8285	55	7	is	be	VBZ
cord-016808-gy8d8285	55	8	also	also	RB
cord-016808-gy8d8285	55	9	variable	variable	JJ
cord-016808-gy8d8285	55	10	,	,	,
cord-016808-gy8d8285	55	11	and	and	CC
cord-016808-gy8d8285	55	12	,	,	,
cord-016808-gy8d8285	55	13	in	in	IN
cord-016808-gy8d8285	55	14	some	some	DT
cord-016808-gy8d8285	55	15	of	of	IN
cord-016808-gy8d8285	55	16	them	-PRON-	PRP
cord-016808-gy8d8285	55	17	,	,	,
cord-016808-gy8d8285	55	18	any	any	DT
cord-016808-gy8d8285	55	19	newly	newly	RB
cord-016808-gy8d8285	55	20	synthesized	synthesize	VBN
cord-016808-gy8d8285	55	21	genomic	genomic	JJ
cord-016808-gy8d8285	55	22	RNA	rna	NN
cord-016808-gy8d8285	55	23	molecule	molecule	NN
cord-016808-gy8d8285	55	24	contains	contain	VBZ
cord-016808-gy8d8285	55	25	on	on	IN
cord-016808-gy8d8285	55	26	an	an	DT
cord-016808-gy8d8285	55	27	average	average	NN
cord-016808-gy8d8285	55	28	a	a	DT
cord-016808-gy8d8285	55	29	mutation	mutation	NN
cord-016808-gy8d8285	55	30	.	.	.
cord-016808-gy8d8285	56	1	Such	such	JJ
cord-016808-gy8d8285	56	2	viruses	virus	NNS
cord-016808-gy8d8285	56	3	exist	exist	VBP
cord-016808-gy8d8285	56	4	on	on	IN
cord-016808-gy8d8285	56	5	the	the	DT
cord-016808-gy8d8285	56	6	edge	edge	NN
cord-016808-gy8d8285	56	7	of	of	IN
cord-016808-gy8d8285	56	8	mutational	mutational	JJ
cord-016808-gy8d8285	56	9	catastrophe	catastrophe	NN
cord-016808-gy8d8285	56	10	:	:	:
cord-016808-gy8d8285	56	11	even	even	RB
cord-016808-gy8d8285	56	12	a	a	DT
cord-016808-gy8d8285	56	13	few	few	JJ
cord-016808-gy8d8285	56	14	-	-	HYPH
cord-016808-gy8d8285	56	15	fold	fold	JJ
cord-016808-gy8d8285	56	16	increase	increase	NN
cord-016808-gy8d8285	56	17	in	in	IN
cord-016808-gy8d8285	56	18	the	the	DT
cord-016808-gy8d8285	56	19	error	error	NN
cord-016808-gy8d8285	56	20	frequency	frequency	NN
cord-016808-gy8d8285	56	21	may	may	MD
cord-016808-gy8d8285	56	22	result	result	VB
cord-016808-gy8d8285	56	23	in	in	IN
cord-016808-gy8d8285	56	24	population	population	NN
cord-016808-gy8d8285	56	25	extinction	extinction	NN
cord-016808-gy8d8285	56	26	.	.	.
cord-016808-gy8d8285	57	1	Nevertheless	nevertheless	RB
cord-016808-gy8d8285	57	2	,	,	,
cord-016808-gy8d8285	57	3	a	a	DT
cord-016808-gy8d8285	57	4	certain	certain	JJ
cord-016808-gy8d8285	57	5	level	level	NN
cord-016808-gy8d8285	57	6	of	of	IN
cord-016808-gy8d8285	57	7	replicative	replicative	JJ
cord-016808-gy8d8285	57	8	infidelity	infidelity	NN
cord-016808-gy8d8285	57	9	is	be	VBZ
cord-016808-gy8d8285	57	10	highly	highly	RB
cord-016808-gy8d8285	57	11	advantageous	advantageous	JJ
cord-016808-gy8d8285	57	12	for	for	IN
cord-016808-gy8d8285	57	13	viruses	virus	NNS
cord-016808-gy8d8285	57	14	since	since	IN
cord-016808-gy8d8285	57	15	it	-PRON-	PRP
cord-016808-gy8d8285	57	16	confers	confer	VBZ
cord-016808-gy8d8285	57	17	a	a	DT
cord-016808-gy8d8285	57	18	potential	potential	NN
cord-016808-gy8d8285	57	19	for	for	IN
cord-016808-gy8d8285	57	20	changing	change	VBG
cord-016808-gy8d8285	57	21	and	and	CC
cord-016808-gy8d8285	57	22	adaptation	adaptation	NN
cord-016808-gy8d8285	57	23	.	.	.
cord-016808-gy8d8285	58	1	For	for	IN
cord-016808-gy8d8285	58	2	example	example	NN
cord-016808-gy8d8285	58	3	,	,	,
cord-016808-gy8d8285	58	4	replicative	replicative	JJ
cord-016808-gy8d8285	58	5	errors	error	NNS
cord-016808-gy8d8285	58	6	are	be	VBP
cord-016808-gy8d8285	58	7	one	one	CD
cord-016808-gy8d8285	58	8	of	of	IN
cord-016808-gy8d8285	58	9	the	the	DT
cord-016808-gy8d8285	58	10	major	major	JJ
cord-016808-gy8d8285	58	11	factors	factor	NNS
cord-016808-gy8d8285	58	12	contributing	contribute	VBG
cord-016808-gy8d8285	58	13	to	to	IN
cord-016808-gy8d8285	58	14	the	the	DT
cord-016808-gy8d8285	58	15	development	development	NN
cord-016808-gy8d8285	58	16	of	of	IN
cord-016808-gy8d8285	58	17	drug	drug	NN
cord-016808-gy8d8285	58	18	-	-	HYPH
cord-016808-gy8d8285	58	19	resistance	resistance	NN
cord-016808-gy8d8285	58	20	and	and	CC
cord-016808-gy8d8285	58	21	hence	hence	RB
cord-016808-gy8d8285	58	22	to	to	IN
cord-016808-gy8d8285	58	23	the	the	DT
cord-016808-gy8d8285	58	24	scarcity	scarcity	NN
cord-016808-gy8d8285	58	25	of	of	IN
cord-016808-gy8d8285	58	26	efficacious	efficacious	JJ
cord-016808-gy8d8285	58	27	antiviral	antiviral	JJ
cord-016808-gy8d8285	58	28	drugs	drug	NNS
cord-016808-gy8d8285	58	29	.	.	.
cord-016808-gy8d8285	59	1	Interestingly	interestingly	RB
cord-016808-gy8d8285	59	2	,	,	,
cord-016808-gy8d8285	59	3	a	a	DT
cord-016808-gy8d8285	59	4	single	single	JJ
cord-016808-gy8d8285	59	5	point	point	NN
cord-016808-gy8d8285	59	6	mutation	mutation	NN
cord-016808-gy8d8285	59	7	in	in	IN
cord-016808-gy8d8285	59	8	the	the	DT
cord-016808-gy8d8285	59	9	poliovirus	poliovirus	NN
cord-016808-gy8d8285	59	10	RNA	rna	NN
cord-016808-gy8d8285	59	11	-	-	HYPH
cord-016808-gy8d8285	59	12	dependent	dependent	JJ
cord-016808-gy8d8285	59	13	RNA	RNA	NNP
cord-016808-gy8d8285	59	14	polymerase	polymerase	NN
cord-016808-gy8d8285	59	15	increases	increase	VBZ
cord-016808-gy8d8285	59	16	its	-PRON-	PRP$
cord-016808-gy8d8285	59	17	fidelity	fidelity	NN
cord-016808-gy8d8285	59	18	several	several	RB
cord-016808-gy8d8285	59	19	-	-	HYPH
cord-016808-gy8d8285	59	20	fold	fold	NN
cord-016808-gy8d8285	59	21	.	.	.
cord-016808-gy8d8285	60	1	However	however	RB
cord-016808-gy8d8285	60	2	,	,	,
cord-016808-gy8d8285	60	3	the	the	DT
cord-016808-gy8d8285	60	4	more	more	RBR
cord-016808-gy8d8285	60	5	accurate	accurate	JJ
cord-016808-gy8d8285	60	6	mutant	mutant	NN
cord-016808-gy8d8285	60	7	is	be	VBZ
cord-016808-gy8d8285	60	8	less	less	RBR
cord-016808-gy8d8285	60	9	fit	fit	JJ
cord-016808-gy8d8285	60	10	:	:	:
cord-016808-gy8d8285	60	11	not	not	RB
cord-016808-gy8d8285	60	12	only	only	RB
cord-016808-gy8d8285	60	13	it	-PRON-	PRP
cord-016808-gy8d8285	60	14	develops	develop	VBZ
cord-016808-gy8d8285	60	15	drug	drug	NN
cord-016808-gy8d8285	60	16	-	-	HYPH
cord-016808-gy8d8285	60	17	resistance	resistance	NN
cord-016808-gy8d8285	60	18	less	less	RBR
cord-016808-gy8d8285	60	19	readily	readily	RB
cord-016808-gy8d8285	60	20	,	,	,
cord-016808-gy8d8285	60	21	but	but	CC
cord-016808-gy8d8285	60	22	is	be	VBZ
cord-016808-gy8d8285	60	23	also	also	RB
cord-016808-gy8d8285	60	24	less	less	JJR
cord-016808-gy8d8285	60	25	neurovirulent	neurovirulent	NN
cord-016808-gy8d8285	60	26	Kirkegaard	Kirkegaard	NNP
cord-016808-gy8d8285	60	27	,	,	,
cord-016808-gy8d8285	60	28	2003	2003	CD
cord-016808-gy8d8285	60	29	,	,	,
cord-016808-gy8d8285	60	30	2005	2005	CD
cord-016808-gy8d8285	60	31	;	;	:
cord-016808-gy8d8285	60	32	Vignuzzi	Vignuzzi	NNP
cord-016808-gy8d8285	60	33	et	et	NNP
cord-016808-gy8d8285	60	34	al	al	NNP
cord-016808-gy8d8285	60	35	.	.	NNP
cord-016808-gy8d8285	60	36	,	,	,
cord-016808-gy8d8285	60	37	2006	2006	CD
cord-016808-gy8d8285	60	38	)	)	-RRB-
cord-016808-gy8d8285	60	39	.	.	.
cord-016808-gy8d8285	61	1	A	a	DT
cord-016808-gy8d8285	61	2	heterogeneous	heterogeneous	JJ
cord-016808-gy8d8285	61	3	population	population	NN
cord-016808-gy8d8285	61	4	,	,	,
cord-016808-gy8d8285	61	5	as	as	IN
cord-016808-gy8d8285	61	6	a	a	DT
cord-016808-gy8d8285	61	7	group	group	NN
cord-016808-gy8d8285	61	8	,	,	,
cord-016808-gy8d8285	61	9	may	may	MD
cord-016808-gy8d8285	61	10	have	have	VB
cord-016808-gy8d8285	61	11	advantages	advantage	NNS
cord-016808-gy8d8285	61	12	over	over	IN
cord-016808-gy8d8285	61	13	a	a	DT
cord-016808-gy8d8285	61	14	more	more	RBR
cord-016808-gy8d8285	61	15	homogeneous	homogeneous	JJ
cord-016808-gy8d8285	61	16	population	population	NN
cord-016808-gy8d8285	61	17	.	.	.
cord-016808-gy8d8285	62	1	The	the	DT
cord-016808-gy8d8285	62	2	advantages	advantage	NNS
cord-016808-gy8d8285	62	3	may	may	MD
cord-016808-gy8d8285	62	4	be	be	VB
cord-016808-gy8d8285	62	5	due	due	JJ
cord-016808-gy8d8285	62	6	not	not	RB
cord-016808-gy8d8285	62	7	only	only	RB
cord-016808-gy8d8285	62	8	to	to	IN
cord-016808-gy8d8285	62	9	a	a	DT
cord-016808-gy8d8285	62	10	greater	great	JJR
cord-016808-gy8d8285	62	11	potential	potential	NN
cord-016808-gy8d8285	62	12	for	for	IN
cord-016808-gy8d8285	62	13	adaptation	adaptation	NN
cord-016808-gy8d8285	62	14	but	but	CC
cord-016808-gy8d8285	62	15	also	also	RB
cord-016808-gy8d8285	62	16	to	to	IN
cord-016808-gy8d8285	62	17	the	the	DT
cord-016808-gy8d8285	62	18	possibility	possibility	NN
cord-016808-gy8d8285	62	19	of	of	IN
cord-016808-gy8d8285	62	20	mutual	mutual	JJ
cord-016808-gy8d8285	62	21	cooperation	cooperation	NN
cord-016808-gy8d8285	62	22	.	.	.
cord-016808-gy8d8285	63	1	The	the	DT
cord-016808-gy8d8285	63	2	genome	genome	NN
cord-016808-gy8d8285	63	3	instability	instability	NN
cord-016808-gy8d8285	63	4	challenges	challenge	VBZ
cord-016808-gy8d8285	63	5	the	the	DT
cord-016808-gy8d8285	63	6	very	very	JJ
cord-016808-gy8d8285	63	7	identity	identity	NN
cord-016808-gy8d8285	63	8	of	of	IN
cord-016808-gy8d8285	63	9	viruses	virus	NNS
cord-016808-gy8d8285	63	10	:	:	:
cord-016808-gy8d8285	64	1	how	how	WRB
cord-016808-gy8d8285	64	2	does	do	VBZ
cord-016808-gy8d8285	64	3	virus	virus	NN
cord-016808-gy8d8285	64	4	X	X	NNS
cord-016808-gy8d8285	64	5	remain	remain	VBP
cord-016808-gy8d8285	64	6	virus	virus	NN
cord-016808-gy8d8285	64	7	X	x	NN
cord-016808-gy8d8285	64	8	?	?	.
cord-016808-gy8d8285	65	1	However	however	RB
cord-016808-gy8d8285	65	2	,	,	,
cord-016808-gy8d8285	65	3	despite	despite	IN
cord-016808-gy8d8285	65	4	their	-PRON-	PRP$
cord-016808-gy8d8285	65	5	intrinsic	intrinsic	JJ
cord-016808-gy8d8285	65	6	instability	instability	NN
cord-016808-gy8d8285	65	7	,	,	,
cord-016808-gy8d8285	65	8	viral	viral	JJ
cord-016808-gy8d8285	65	9	genomes	genome	NNS
cord-016808-gy8d8285	65	10	,	,	,
cord-016808-gy8d8285	65	11	even	even	RB
cord-016808-gy8d8285	65	12	in	in	IN
cord-016808-gy8d8285	65	13	the	the	DT
cord-016808-gy8d8285	65	14	extreme	extreme	JJ
cord-016808-gy8d8285	65	15	case	case	NN
cord-016808-gy8d8285	65	16	of	of	IN
cord-016808-gy8d8285	65	17	RNA	RNA	NNP
cord-016808-gy8d8285	65	18	viruses	virus	NNS
cord-016808-gy8d8285	65	19	,	,	,
cord-016808-gy8d8285	65	20	are	be	VBP
cord-016808-gy8d8285	65	21	remarkably	remarkably	RB
cord-016808-gy8d8285	65	22	robust	robust	JJ
cord-016808-gy8d8285	65	23	.	.	.
cord-016808-gy8d8285	66	1	Several	several	JJ
cord-016808-gy8d8285	66	2	factors	factor	NNS
cord-016808-gy8d8285	66	3	contribute	contribute	VBP
cord-016808-gy8d8285	66	4	to	to	IN
cord-016808-gy8d8285	66	5	the	the	DT
cord-016808-gy8d8285	66	6	genetic	genetic	JJ
cord-016808-gy8d8285	66	7	stability	stability	NN
cord-016808-gy8d8285	66	8	of	of	IN
cord-016808-gy8d8285	66	9	viruses	virus	NNS
cord-016808-gy8d8285	66	10	in	in	IN
cord-016808-gy8d8285	66	11	nature	nature	NN
cord-016808-gy8d8285	66	12	.	.	.
cord-016808-gy8d8285	67	1	Adverse	adverse	JJ
cord-016808-gy8d8285	67	2	mutations	mutation	NNS
cord-016808-gy8d8285	67	3	are	be	VBP
cord-016808-gy8d8285	67	4	eliminated	eliminate	VBN
cord-016808-gy8d8285	67	5	by	by	IN
cord-016808-gy8d8285	67	6	negative	negative	JJ
cord-016808-gy8d8285	67	7	selection	selection	NN
cord-016808-gy8d8285	67	8	,	,	,
cord-016808-gy8d8285	67	9	whereas	whereas	IN
cord-016808-gy8d8285	67	10	fitness	fitness	NN
cord-016808-gy8d8285	67	11	-	-	HYPH
cord-016808-gy8d8285	67	12	increasing	increase	VBG
cord-016808-gy8d8285	67	13	mutations	mutation	NNS
cord-016808-gy8d8285	67	14	are	be	VBP
cord-016808-gy8d8285	67	15	nearly	nearly	RB
cord-016808-gy8d8285	67	16	not	not	RB
cord-016808-gy8d8285	67	17	-	-	HYPH
cord-016808-gy8d8285	67	18	existing	exist	VBG
cord-016808-gy8d8285	67	19	in	in	IN
cord-016808-gy8d8285	67	20	constant	constant	JJ
cord-016808-gy8d8285	67	21	environment	environment	NN
cord-016808-gy8d8285	67	22	.	.	.
cord-016808-gy8d8285	68	1	Adaptive	adaptive	JJ
cord-016808-gy8d8285	68	2	mutations	mutation	NNS
cord-016808-gy8d8285	68	3	may	may	MD
cord-016808-gy8d8285	68	4	be	be	VB
cord-016808-gy8d8285	68	5	positively	positively	RB
cord-016808-gy8d8285	68	6	selected	select	VBN
cord-016808-gy8d8285	68	7	upon	upon	IN
cord-016808-gy8d8285	68	8	environmental	environmental	JJ
cord-016808-gy8d8285	68	9	changes	change	NNS
cord-016808-gy8d8285	68	10	(	(	-LRB-
cord-016808-gy8d8285	68	11	including	include	VBG
cord-016808-gy8d8285	68	12	infection	infection	NN
cord-016808-gy8d8285	68	13	of	of	IN
cord-016808-gy8d8285	68	14	a	a	DT
cord-016808-gy8d8285	68	15	novel	novel	JJ
cord-016808-gy8d8285	68	16	host	host	NN
cord-016808-gy8d8285	68	17	species	specie	NNS
cord-016808-gy8d8285	68	18	)	)	-RRB-
cord-016808-gy8d8285	68	19	.	.	.
cord-016808-gy8d8285	69	1	The	the	DT
cord-016808-gy8d8285	69	2	only	only	JJ
cord-016808-gy8d8285	69	3	major	major	JJ
cord-016808-gy8d8285	69	4	factor	factor	NN
cord-016808-gy8d8285	69	5	favoring	favor	VBG
cord-016808-gy8d8285	69	6	accumulation	accumulation	NN
cord-016808-gy8d8285	69	7	of	of	IN
cord-016808-gy8d8285	69	8	neutral	neutral	JJ
cord-016808-gy8d8285	69	9	mutations	mutation	NNS
cord-016808-gy8d8285	69	10	is	be	VBZ
cord-016808-gy8d8285	69	11	bottlenecking	bottleneck	VBG
cord-016808-gy8d8285	69	12	(	(	-LRB-
cord-016808-gy8d8285	69	13	stochastic	stochastic	JJ
cord-016808-gy8d8285	69	14	picking	pick	VBG
cord-016808-gy8d8285	69	15	up	up	RP
cord-016808-gy8d8285	69	16	a	a	DT
cord-016808-gy8d8285	69	17	single	single	JJ
cord-016808-gy8d8285	69	18	viral	viral	JJ
cord-016808-gy8d8285	69	19	particle	particle	NN
cord-016808-gy8d8285	69	20	,	,	,
cord-016808-gy8d8285	69	21	or	or	CC
cord-016808-gy8d8285	69	22	a	a	DT
cord-016808-gy8d8285	69	23	few	few	JJ
cord-016808-gy8d8285	69	24	of	of	IN
cord-016808-gy8d8285	69	25	them	-PRON-	PRP
cord-016808-gy8d8285	69	26	,	,	,
cord-016808-gy8d8285	69	27	from	from	IN
cord-016808-gy8d8285	69	28	a	a	DT
cord-016808-gy8d8285	69	29	heterogeneous	heterogeneous	JJ
cord-016808-gy8d8285	69	30	population	population	NN
cord-016808-gy8d8285	69	31	)	)	-RRB-
cord-016808-gy8d8285	69	32	,	,	,
cord-016808-gy8d8285	69	33	which	which	WDT
cord-016808-gy8d8285	69	34	is	be	VBZ
cord-016808-gy8d8285	69	35	quite	quite	RB
cord-016808-gy8d8285	69	36	common	common	JJ
cord-016808-gy8d8285	69	37	during	during	IN
cord-016808-gy8d8285	69	38	natural	natural	JJ
cord-016808-gy8d8285	69	39	transmission	transmission	NN
cord-016808-gy8d8285	69	40	of	of	IN
cord-016808-gy8d8285	69	41	viruses	virus	NNS
cord-016808-gy8d8285	69	42	.	.	.
cord-016808-gy8d8285	70	1	Consecutive	consecutive	JJ
cord-016808-gy8d8285	70	2	bottlenecking	bottleneck	VBG
cord-016808-gy8d8285	70	3	events	event	NNS
cord-016808-gy8d8285	70	4	may	may	MD
cord-016808-gy8d8285	70	5	result	result	VB
cord-016808-gy8d8285	70	6	in	in	IN
cord-016808-gy8d8285	70	7	a	a	DT
cord-016808-gy8d8285	70	8	more	more	RBR
cord-016808-gy8d8285	70	9	or	or	CC
cord-016808-gy8d8285	70	10	less	less	RBR
cord-016808-gy8d8285	70	11	marked	marked	JJ
cord-016808-gy8d8285	70	12	decrease	decrease	NN
cord-016808-gy8d8285	70	13	in	in	IN
cord-016808-gy8d8285	70	14	viral	viral	JJ
cord-016808-gy8d8285	70	15	fitness	fitness	NN
cord-016808-gy8d8285	70	16	(	(	-LRB-
cord-016808-gy8d8285	70	17	the	the	DT
cord-016808-gy8d8285	70	18	so	so	RB
cord-016808-gy8d8285	70	19	called	call	VBN
cord-016808-gy8d8285	70	20	Muller	Muller	NNP
cord-016808-gy8d8285	70	21	's	's	POS
cord-016808-gy8d8285	70	22	ratchet	ratchet	NN
cord-016808-gy8d8285	70	23	)	)	-RRB-
cord-016808-gy8d8285	70	24	because	because	IN
cord-016808-gy8d8285	70	25	viral	viral	JJ
cord-016808-gy8d8285	70	26	genomes	genome	NNS
cord-016808-gy8d8285	70	27	picked	pick	VBN
cord-016808-gy8d8285	70	28	up	up	RP
cord-016808-gy8d8285	70	29	by	by	IN
cord-016808-gy8d8285	70	30	chance	chance	NN
cord-016808-gy8d8285	70	31	from	from	IN
cord-016808-gy8d8285	70	32	a	a	DT
cord-016808-gy8d8285	70	33	heterogeneous	heterogeneous	JJ
cord-016808-gy8d8285	70	34	population	population	NN
cord-016808-gy8d8285	70	35	may	may	MD
cord-016808-gy8d8285	70	36	well	well	RB
cord-016808-gy8d8285	70	37	harbor	harbor	VB
cord-016808-gy8d8285	70	38	detrimental	detrimental	JJ
cord-016808-gy8d8285	70	39	mutations	mutation	NNS
cord-016808-gy8d8285	70	40	.	.	.
cord-016808-gy8d8285	71	1	To	to	TO
cord-016808-gy8d8285	71	2	what	what	WDT
cord-016808-gy8d8285	71	3	extent	extent	NN
cord-016808-gy8d8285	71	4	is	be	VBZ
cord-016808-gy8d8285	71	5	the	the	DT
cord-016808-gy8d8285	71	6	Muller	Muller	NNP
cord-016808-gy8d8285	71	7	's	's	POS
cord-016808-gy8d8285	71	8	ratchet	ratchet	NN
cord-016808-gy8d8285	71	9	inevitable	inevitable	JJ
cord-016808-gy8d8285	71	10	and	and	CC
cord-016808-gy8d8285	71	11	irreversible	irreversible	JJ
cord-016808-gy8d8285	71	12	?	?	.
cord-016808-gy8d8285	72	1	The	the	DT
cord-016808-gy8d8285	72	2	robustness	robustness	NN
cord-016808-gy8d8285	72	3	of	of	IN
cord-016808-gy8d8285	72	4	viruses	virus	NNS
cord-016808-gy8d8285	72	5	may	may	MD
cord-016808-gy8d8285	72	6	be	be	VB
cord-016808-gy8d8285	72	7	studied	study	VBN
cord-016808-gy8d8285	72	8	experimentally	experimentally	RB
cord-016808-gy8d8285	72	9	by	by	IN
cord-016808-gy8d8285	72	10	damaging	damage	VBG
cord-016808-gy8d8285	72	11	their	-PRON-	PRP$
cord-016808-gy8d8285	72	12	genome	genome	NN
cord-016808-gy8d8285	72	13	(	(	-LRB-
cord-016808-gy8d8285	72	14	e.g.	e.g.	RB
cord-016808-gy8d8285	72	15	,	,	,
cord-016808-gy8d8285	72	16	by	by	IN
cord-016808-gy8d8285	72	17	introducing	introduce	VBG
cord-016808-gy8d8285	72	18	point	point	NN
cord-016808-gy8d8285	72	19	mutations	mutation	NNS
cord-016808-gy8d8285	72	20	or	or	CC
cord-016808-gy8d8285	72	21	deletions	deletion	NNS
cord-016808-gy8d8285	72	22	,	,	,
cord-016808-gy8d8285	72	23	randomization	randomization	NN
cord-016808-gy8d8285	72	24	of	of	IN
cord-016808-gy8d8285	72	25	portions	portion	NNS
cord-016808-gy8d8285	72	26	of	of	IN
cord-016808-gy8d8285	72	27	the	the	DT
cord-016808-gy8d8285	72	28	nucleotide	nucleotide	JJ
cord-016808-gy8d8285	72	29	sequence	sequence	NN
cord-016808-gy8d8285	72	30	,	,	,
cord-016808-gy8d8285	72	31	or	or	CC
cord-016808-gy8d8285	72	32	even	even	RB
cord-016808-gy8d8285	72	33	breaking	break	VBG
cord-016808-gy8d8285	72	34	the	the	DT
cord-016808-gy8d8285	72	35	genome	genome	NN
cord-016808-gy8d8285	72	36	apart	apart	RB
cord-016808-gy8d8285	72	37	)	)	-RRB-
cord-016808-gy8d8285	72	38	followed	follow	VBN
cord-016808-gy8d8285	72	39	by	by	IN
cord-016808-gy8d8285	72	40	investigating	investigate	VBG
cord-016808-gy8d8285	72	41	viral	viral	JJ
cord-016808-gy8d8285	72	42	viability	viability	NN
cord-016808-gy8d8285	72	43	and	and	CC
cord-016808-gy8d8285	72	44	fitness	fitness	NN
cord-016808-gy8d8285	72	45	as	as	RB
cord-016808-gy8d8285	72	46	well	well	RB
cord-016808-gy8d8285	72	47	as	as	IN
cord-016808-gy8d8285	72	48	structure	structure	NN
cord-016808-gy8d8285	72	49	and	and	CC
cord-016808-gy8d8285	72	50	stability	stability	NN
cord-016808-gy8d8285	72	51	of	of	IN
cord-016808-gy8d8285	72	52	the	the	DT
cord-016808-gy8d8285	72	53	mutated	mutate	VBN
cord-016808-gy8d8285	72	54	viral	viral	JJ
cord-016808-gy8d8285	72	55	genome	genome	NN
cord-016808-gy8d8285	72	56	.	.	.
cord-016808-gy8d8285	73	1	A	a	DT
cord-016808-gy8d8285	73	2	wealth	wealth	NN
cord-016808-gy8d8285	73	3	of	of	IN
cord-016808-gy8d8285	73	4	relevant	relevant	JJ
cord-016808-gy8d8285	73	5	information	information	NN
cord-016808-gy8d8285	73	6	concerning	concern	VBG
cord-016808-gy8d8285	73	7	numerous	numerous	JJ
cord-016808-gy8d8285	73	8	viruses	virus	NNS
cord-016808-gy8d8285	73	9	has	have	VBZ
cord-016808-gy8d8285	73	10	already	already	RB
cord-016808-gy8d8285	73	11	been	be	VBN
cord-016808-gy8d8285	73	12	accumulated	accumulate	VBN
cord-016808-gy8d8285	73	13	in	in	IN
cord-016808-gy8d8285	73	14	literature	literature	NN
cord-016808-gy8d8285	73	15	.	.	.
cord-016808-gy8d8285	74	1	Some	some	DT
cord-016808-gy8d8285	74	2	examples	example	NNS
cord-016808-gy8d8285	74	3	of	of	IN
cord-016808-gy8d8285	74	4	such	such	JJ
cord-016808-gy8d8285	74	5	"	"	``
cord-016808-gy8d8285	74	6	interrogation	interrogation	NN
cord-016808-gy8d8285	74	7	under	under	IN
cord-016808-gy8d8285	74	8	torture	torture	NN
cord-016808-gy8d8285	74	9	"	"	``
cord-016808-gy8d8285	74	10	carried	carry	VBN
cord-016808-gy8d8285	74	11	out	out	RP
cord-016808-gy8d8285	74	12	with	with	IN
cord-016808-gy8d8285	74	13	picornaviruses	picornavirus	NNS
cord-016808-gy8d8285	74	14	in	in	IN
cord-016808-gy8d8285	74	15	the	the	DT
cord-016808-gy8d8285	74	16	author	author	NN
cord-016808-gy8d8285	74	17	's	's	POS
cord-016808-gy8d8285	74	18	laboratory	laboratory	NN
cord-016808-gy8d8285	74	19	are	be	VBP
cord-016808-gy8d8285	74	20	presented	present	VBN
cord-016808-gy8d8285	74	21	below	below	RB
cord-016808-gy8d8285	74	22	.	.	.
cord-016808-gy8d8285	75	1	The	the	DT
cord-016808-gy8d8285	75	2	Theiler	Theiler	NNP
cord-016808-gy8d8285	75	3	's	's	POS
cord-016808-gy8d8285	75	4	murine	murine	JJ
cord-016808-gy8d8285	75	5	encephalomyelitis	encephalomyelitis	NN
cord-016808-gy8d8285	75	6	virus	virus	NN
cord-016808-gy8d8285	75	7	(	(	-LRB-
cord-016808-gy8d8285	75	8	TMEV	TMEV	NNP
cord-016808-gy8d8285	75	9	)	)	-RRB-
cord-016808-gy8d8285	75	10	is	be	VBZ
cord-016808-gy8d8285	75	11	highly	highly	RB
cord-016808-gy8d8285	75	12	pathogenic	pathogenic	JJ
cord-016808-gy8d8285	75	13	for	for	IN
cord-016808-gy8d8285	75	14	mice	mouse	NNS
cord-016808-gy8d8285	75	15	under	under	IN
cord-016808-gy8d8285	75	16	certain	certain	JJ
cord-016808-gy8d8285	75	17	conditions	condition	NNS
cord-016808-gy8d8285	75	18	:	:	:
cord-016808-gy8d8285	75	19	a	a	DT
cord-016808-gy8d8285	75	20	few	few	JJ
cord-016808-gy8d8285	75	21	wild	wild	JJ
cord-016808-gy8d8285	75	22	type	type	NN
cord-016808-gy8d8285	75	23	viral	viral	JJ
cord-016808-gy8d8285	75	24	particles	particle	NNS
cord-016808-gy8d8285	75	25	injected	inject	VBN
cord-016808-gy8d8285	75	26	intracerebrally	intracerebrally	RB
cord-016808-gy8d8285	75	27	kill	kill	VBP
cord-016808-gy8d8285	75	28	mice	mouse	NNS
cord-016808-gy8d8285	75	29	.	.	.
cord-016808-gy8d8285	76	1	For	for	IN
cord-016808-gy8d8285	76	2	efficient	efficient	JJ
cord-016808-gy8d8285	76	3	viral	viral	JJ
cord-016808-gy8d8285	76	4	reproduction	reproduction	NN
cord-016808-gy8d8285	76	5	in	in	IN
cord-016808-gy8d8285	76	6	the	the	DT
cord-016808-gy8d8285	76	7	brain	brain	NN
cord-016808-gy8d8285	76	8	,	,	,
cord-016808-gy8d8285	76	9	interaction	interaction	NN
cord-016808-gy8d8285	76	10	of	of	IN
cord-016808-gy8d8285	76	11	a	a	DT
cord-016808-gy8d8285	76	12	translational	translational	JJ
cord-016808-gy8d8285	76	13	control	control	NN
cord-016808-gy8d8285	76	14	element	element	NN
cord-016808-gy8d8285	76	15	(	(	-LRB-
cord-016808-gy8d8285	76	16	IRES	IRES	NNP
cord-016808-gy8d8285	76	17	)	)	-RRB-
cord-016808-gy8d8285	76	18	in	in	IN
cord-016808-gy8d8285	76	19	the	the	DT
cord-016808-gy8d8285	76	20	5	5	CD
cord-016808-gy8d8285	76	21	-noncoding	-noncoding	NN
cord-016808-gy8d8285	76	22	region	region	NN
cord-016808-gy8d8285	76	23	(	(	-LRB-
cord-016808-gy8d8285	76	24	5NCR	5ncr	CD
cord-016808-gy8d8285	76	25	)	)	-RRB-
cord-016808-gy8d8285	76	26	of	of	IN
cord-016808-gy8d8285	76	27	the	the	DT
cord-016808-gy8d8285	76	28	viral	viral	JJ
cord-016808-gy8d8285	76	29	RNA	RNA	NNP
cord-016808-gy8d8285	76	30	with	with	IN
cord-016808-gy8d8285	76	31	a	a	DT
cord-016808-gy8d8285	76	32	host	host	NN
cord-016808-gy8d8285	76	33	protein	protein	NN
cord-016808-gy8d8285	76	34	,	,	,
cord-016808-gy8d8285	76	35	neural	neural	JJ
cord-016808-gy8d8285	76	36	polypyrimidine	polypyrimidine	JJ
cord-016808-gy8d8285	76	37	tract	tract	NN
cord-016808-gy8d8285	76	38	-	-	HYPH
cord-016808-gy8d8285	76	39	binding	bind	VBG
cord-016808-gy8d8285	76	40	protein	protein	NN
cord-016808-gy8d8285	76	41	(	(	-LRB-
cord-016808-gy8d8285	76	42	nPTB	nptb	NN
cord-016808-gy8d8285	76	43	)	)	-RRB-
cord-016808-gy8d8285	76	44	,	,	,
cord-016808-gy8d8285	76	45	is	be	VBZ
cord-016808-gy8d8285	76	46	essential	essential	JJ
cord-016808-gy8d8285	76	47	(	(	-LRB-
cord-016808-gy8d8285	77	1	Pilipenko	Pilipenko	NNP
cord-016808-gy8d8285	77	2	et	et	NNP
cord-016808-gy8d8285	77	3	al	al	NNP
cord-016808-gy8d8285	77	4	.	.	NNP
cord-016808-gy8d8285	77	5	,	,	,
cord-016808-gy8d8285	77	6	2001	2001	CD
cord-016808-gy8d8285	77	7	)	)	-RRB-
cord-016808-gy8d8285	77	8	.	.	.
cord-016808-gy8d8285	78	1	A	a	DT
cord-016808-gy8d8285	78	2	single	single	JJ
cord-016808-gy8d8285	78	3	point	point	NN
cord-016808-gy8d8285	78	4	mutation	mutation	NN
cord-016808-gy8d8285	78	5	in	in	IN
cord-016808-gy8d8285	78	6	one	one	CD
cord-016808-gy8d8285	78	7	of	of	IN
cord-016808-gy8d8285	78	8	the	the	DT
cord-016808-gy8d8285	78	9	nPTB	nptb	NN
cord-016808-gy8d8285	78	10	-	-	HYPH
cord-016808-gy8d8285	78	11	binding	bind	VBG
cord-016808-gy8d8285	78	12	sites	site	NNS
cord-016808-gy8d8285	78	13	of	of	IN
cord-016808-gy8d8285	78	14	the	the	DT
cord-016808-gy8d8285	78	15	viral	viral	JJ
cord-016808-gy8d8285	78	16	RNA	RNA	NNP
cord-016808-gy8d8285	78	17	led	lead	VBD
cord-016808-gy8d8285	78	18	to	to	IN
cord-016808-gy8d8285	78	19	a	a	DT
cord-016808-gy8d8285	78	20	dramatic	dramatic	JJ
cord-016808-gy8d8285	78	21	decrease	decrease	NN
cord-016808-gy8d8285	78	22	in	in	IN
cord-016808-gy8d8285	78	23	viral	viral	JJ
cord-016808-gy8d8285	78	24	neurovirulence	neurovirulence	NN
cord-016808-gy8d8285	78	25	:	:	:
cord-016808-gy8d8285	78	26	∼10	∼10	NNP
cord-016808-gy8d8285	78	27	4	4	CD
cord-016808-gy8d8285	78	28	more	more	JJR
cord-016808-gy8d8285	78	29	mutant	mutant	JJ
cord-016808-gy8d8285	78	30	particles	particle	NNS
cord-016808-gy8d8285	78	31	were	be	VBD
cord-016808-gy8d8285	78	32	now	now	RB
cord-016808-gy8d8285	78	33	needed	need	VBN
cord-016808-gy8d8285	78	34	to	to	TO
cord-016808-gy8d8285	78	35	kill	kill	VB
cord-016808-gy8d8285	78	36	a	a	DT
cord-016808-gy8d8285	78	37	mouse	mouse	NN
cord-016808-gy8d8285	78	38	.	.	.
cord-016808-gy8d8285	79	1	However	however	RB
cord-016808-gy8d8285	79	2	,	,	,
cord-016808-gy8d8285	79	3	wild	wild	JJ
cord-016808-gy8d8285	79	4	-	-	HYPH
cord-016808-gy8d8285	79	5	type	type	NN
cord-016808-gy8d8285	79	6	level	level	NN
cord-016808-gy8d8285	79	7	of	of	IN
cord-016808-gy8d8285	79	8	neurovirulence	neurovirulence	NN
cord-016808-gy8d8285	79	9	could	could	MD
cord-016808-gy8d8285	79	10	readily	readily	RB
cord-016808-gy8d8285	79	11	be	be	VB
cord-016808-gy8d8285	79	12	restored	restore	VBN
cord-016808-gy8d8285	79	13	by	by	IN
cord-016808-gy8d8285	79	14	either	either	DT
cord-016808-gy8d8285	79	15	reversion	reversion	NN
cord-016808-gy8d8285	79	16	or	or	CC
cord-016808-gy8d8285	79	17	pseudoreversions	pseudoreversion	NNS
cord-016808-gy8d8285	79	18	during	during	IN
cord-016808-gy8d8285	79	19	viral	viral	JJ
cord-016808-gy8d8285	79	20	reproduction	reproduction	NN
cord-016808-gy8d8285	79	21	,	,	,
cord-016808-gy8d8285	79	22	e.g.	e.g.	RB
cord-016808-gy8d8285	79	23	,	,	,
cord-016808-gy8d8285	79	24	by	by	IN
cord-016808-gy8d8285	79	25	generation	generation	NN
cord-016808-gy8d8285	79	26	of	of	IN
cord-016808-gy8d8285	79	27	a	a	DT
cord-016808-gy8d8285	79	28	new	new	JJ
cord-016808-gy8d8285	79	29	nPTB	nptb	NN
cord-016808-gy8d8285	79	30	-	-	HYPH
cord-016808-gy8d8285	79	31	binding	bind	VBG
cord-016808-gy8d8285	79	32	site	site	NN
cord-016808-gy8d8285	79	33	in	in	IN
cord-016808-gy8d8285	79	34	the	the	DT
cord-016808-gy8d8285	79	35	viral	viral	JJ
cord-016808-gy8d8285	79	36	5NCR	5ncr	CD
cord-016808-gy8d8285	79	37	due	due	IN
cord-016808-gy8d8285	79	38	to	to	IN
cord-016808-gy8d8285	79	39	a	a	DT
cord-016808-gy8d8285	79	40	compensating	compensating	NN
cord-016808-gy8d8285	79	41	point	point	NN
cord-016808-gy8d8285	79	42	mutation	mutation	NN
cord-016808-gy8d8285	80	1	(	(	-LRB-
cord-016808-gy8d8285	80	2	Pilipenko	Pilipenko	NNP
cord-016808-gy8d8285	80	3	et	et	NNP
cord-016808-gy8d8285	80	4	al	al	NNP
cord-016808-gy8d8285	80	5	.	.	NNP
cord-016808-gy8d8285	80	6	,	,	,
cord-016808-gy8d8285	80	7	2001	2001	CD
cord-016808-gy8d8285	80	8	)	)	-RRB-
cord-016808-gy8d8285	80	9	.	.	.
cord-016808-gy8d8285	81	1	An	an	DT
cord-016808-gy8d8285	81	2	8-nt	8-nt	CD
cord-016808-gy8d8285	81	3	deletion	deletion	NN
cord-016808-gy8d8285	81	4	in	in	IN
cord-016808-gy8d8285	81	5	the	the	DT
cord-016808-gy8d8285	81	6	5NCR	5ncr	CD
cord-016808-gy8d8285	81	7	of	of	IN
cord-016808-gy8d8285	81	8	poliovirus	poliovirus	NN
cord-016808-gy8d8285	81	9	RNA	RNA	NNP
cord-016808-gy8d8285	81	10	severely	severely	RB
cord-016808-gy8d8285	81	11	impaired	impair	VBD
cord-016808-gy8d8285	81	12	viral	viral	JJ
cord-016808-gy8d8285	81	13	fitness	fitness	NN
cord-016808-gy8d8285	81	14	and	and	CC
cord-016808-gy8d8285	81	15	nearly	nearly	RB
cord-016808-gy8d8285	81	16	killed	kill	VBD
cord-016808-gy8d8285	81	17	the	the	DT
cord-016808-gy8d8285	81	18	virus	virus	NN
cord-016808-gy8d8285	81	19	.	.	.
cord-016808-gy8d8285	82	1	However	however	RB
cord-016808-gy8d8285	82	2	,	,	,
cord-016808-gy8d8285	82	3	this	this	DT
cord-016808-gy8d8285	82	4	defect	defect	NN
cord-016808-gy8d8285	82	5	could	could	MD
cord-016808-gy8d8285	82	6	be	be	VB
cord-016808-gy8d8285	82	7	readily	readily	RB
cord-016808-gy8d8285	82	8	fixed	fix	VBN
cord-016808-gy8d8285	82	9	by	by	IN
cord-016808-gy8d8285	82	10	natural	natural	JJ
cord-016808-gy8d8285	82	11	pseudoreversions	pseudoreversion	NNS
cord-016808-gy8d8285	82	12	of	of	IN
cord-016808-gy8d8285	82	13	at	at	RB
cord-016808-gy8d8285	82	14	least	least	RBS
cord-016808-gy8d8285	82	15	three	three	CD
cord-016808-gy8d8285	82	16	different	different	JJ
cord-016808-gy8d8285	82	17	kinds	kind	NNS
cord-016808-gy8d8285	82	18	,	,	,
cord-016808-gy8d8285	82	19	including	include	VBG
cord-016808-gy8d8285	82	20	point	point	NN
cord-016808-gy8d8285	82	21	mutations	mutation	NNS
cord-016808-gy8d8285	82	22	,	,	,
cord-016808-gy8d8285	82	23	insertions	insertion	NNS
cord-016808-gy8d8285	82	24	and	and	CC
cord-016808-gy8d8285	82	25	extended	extended	JJ
cord-016808-gy8d8285	82	26	deletions	deletion	NNS
cord-016808-gy8d8285	82	27	(	(	-LRB-
cord-016808-gy8d8285	82	28	Pilipenko	Pilipenko	NNP
cord-016808-gy8d8285	82	29	et	et	NNP
cord-016808-gy8d8285	82	30	al	al	NNP
cord-016808-gy8d8285	82	31	.	.	NNP
cord-016808-gy8d8285	82	32	,	,	,
cord-016808-gy8d8285	82	33	1992	1992	CD
cord-016808-gy8d8285	82	34	;	;	.
cord-016808-gy8d8285	83	1	Gmyl	Gmyl	NNP
cord-016808-gy8d8285	83	2	et	et	FW
cord-016808-gy8d8285	83	3	al	al	NNP
cord-016808-gy8d8285	83	4	.	.	NNP
cord-016808-gy8d8285	83	5	,	,	,
cord-016808-gy8d8285	83	6	1993	1993	CD
cord-016808-gy8d8285	83	7	)	)	-RRB-
cord-016808-gy8d8285	83	8	.	.	.
cord-016808-gy8d8285	84	1	The	the	DT
cord-016808-gy8d8285	84	2	results	result	NNS
cord-016808-gy8d8285	84	3	of	of	IN
cord-016808-gy8d8285	84	4	these	these	DT
cord-016808-gy8d8285	84	5	and	and	CC
cord-016808-gy8d8285	84	6	other	other	JJ
cord-016808-gy8d8285	84	7	experiments	experiment	NNS
cord-016808-gy8d8285	84	8	show	show	VBP
cord-016808-gy8d8285	84	9	that	that	IN
cord-016808-gy8d8285	84	10	many	many	JJ
cord-016808-gy8d8285	84	11	mutations	mutation	NNS
cord-016808-gy8d8285	84	12	and	and	CC
cord-016808-gy8d8285	84	13	their	-PRON-	PRP$
cord-016808-gy8d8285	84	14	combinations	combination	NNS
cord-016808-gy8d8285	84	15	are	be	VBP
cord-016808-gy8d8285	84	16	life	life	NN
cord-016808-gy8d8285	84	17	-	-	HYPH
cord-016808-gy8d8285	84	18	compatible	compatible	JJ
cord-016808-gy8d8285	84	19	and	and	CC
cord-016808-gy8d8285	84	20	may	may	MD
cord-016808-gy8d8285	84	21	not	not	RB
cord-016808-gy8d8285	84	22	decrease	decrease	VB
cord-016808-gy8d8285	84	23	viral	viral	JJ
cord-016808-gy8d8285	84	24	fitness	fitness	NN
cord-016808-gy8d8285	84	25	and	and	CC
cord-016808-gy8d8285	84	26	,	,	,
cord-016808-gy8d8285	84	27	if	if	IN
cord-016808-gy8d8285	84	28	they	-PRON-	PRP
cord-016808-gy8d8285	84	29	have	have	VBP
cord-016808-gy8d8285	84	30	adverse	adverse	JJ
cord-016808-gy8d8285	84	31	effects	effect	NNS
cord-016808-gy8d8285	84	32	,	,	,
cord-016808-gy8d8285	84	33	these	these	DT
cord-016808-gy8d8285	84	34	effects	effect	NNS
cord-016808-gy8d8285	84	35	may	may	MD
cord-016808-gy8d8285	84	36	often	often	RB
cord-016808-gy8d8285	84	37	be	be	VB
cord-016808-gy8d8285	84	38	repaired	repair	VBN
cord-016808-gy8d8285	84	39	or	or	CC
cord-016808-gy8d8285	84	40	compensated	compensate	VBN
cord-016808-gy8d8285	84	41	.	.	.
cord-016808-gy8d8285	85	1	Even	even	RB
cord-016808-gy8d8285	85	2	broken	broken	JJ
cord-016808-gy8d8285	85	3	molecules	molecule	NNS
cord-016808-gy8d8285	85	4	of	of	IN
cord-016808-gy8d8285	85	5	genomic	genomic	JJ
cord-016808-gy8d8285	85	6	RNA	RNA	NNP
cord-016808-gy8d8285	85	7	may	may	MD
cord-016808-gy8d8285	85	8	sometimes	sometimes	RB
cord-016808-gy8d8285	85	9	be	be	VB
cord-016808-gy8d8285	85	10	repaired	repair	VBN
cord-016808-gy8d8285	85	11	by	by	IN
cord-016808-gy8d8285	85	12	recombination	recombination	NN
cord-016808-gy8d8285	85	13	(	(	-LRB-
cord-016808-gy8d8285	85	14	Gmyl	Gmyl	NNP
cord-016808-gy8d8285	85	15	et	et	FW
cord-016808-gy8d8285	85	16	al	al	NNP
cord-016808-gy8d8285	85	17	.	.	NNP
cord-016808-gy8d8285	85	18	,	,	,
cord-016808-gy8d8285	85	19	1999	1999	CD
cord-016808-gy8d8285	85	20	(	(	-LRB-
cord-016808-gy8d8285	85	21	Gmyl	Gmyl	NNP
cord-016808-gy8d8285	85	22	et	et	FW
cord-016808-gy8d8285	85	23	al	al	NNP
cord-016808-gy8d8285	85	24	.	.	NNP
cord-016808-gy8d8285	85	25	,	,	,
cord-016808-gy8d8285	85	26	,	,	,
cord-016808-gy8d8285	85	27	2003	2003	CD
cord-016808-gy8d8285	85	28	.	.	.
cord-016808-gy8d8285	86	1	Thus	thus	RB
cord-016808-gy8d8285	86	2	,	,	,
cord-016808-gy8d8285	86	3	viral	viral	JJ
cord-016808-gy8d8285	86	4	RNA	RNA	NNP
cord-016808-gy8d8285	86	5	genomes	genome	NNS
cord-016808-gy8d8285	86	6	are	be	VBP
cord-016808-gy8d8285	86	7	robust	robust	JJ
cord-016808-gy8d8285	86	8	and	and	CC
cord-016808-gy8d8285	86	9	exhibit	exhibit	VB
cord-016808-gy8d8285	86	10	remarkable	remarkable	JJ
cord-016808-gy8d8285	86	11	vitality	vitality	NN
cord-016808-gy8d8285	86	12	and	and	CC
cord-016808-gy8d8285	86	13	phoenix	phoenix	NNP
cord-016808-gy8d8285	86	14	-	-	HYPH
cord-016808-gy8d8285	86	15	like	like	JJ
cord-016808-gy8d8285	86	16	phenotype	phenotype	NN
cord-016808-gy8d8285	86	17	.	.	.
cord-016808-gy8d8285	87	1	What	what	WP
cord-016808-gy8d8285	87	2	does	do	VBZ
cord-016808-gy8d8285	87	3	then	then	RB
cord-016808-gy8d8285	87	4	force	force	VB
cord-016808-gy8d8285	87	5	them	-PRON-	PRP
cord-016808-gy8d8285	87	6	to	to	TO
cord-016808-gy8d8285	87	7	evolve	evolve	VB
cord-016808-gy8d8285	87	8	and	and	CC
cord-016808-gy8d8285	87	9	to	to	TO
cord-016808-gy8d8285	87	10	form	form	VB
cord-016808-gy8d8285	87	11	new	new	JJ
cord-016808-gy8d8285	87	12	species	specie	NNS
cord-016808-gy8d8285	87	13	and	and	CC
cord-016808-gy8d8285	87	14	genera	genus	NNS
cord-016808-gy8d8285	87	15	?	?	.
cord-016808-gy8d8285	88	1	A	a	DT
cord-016808-gy8d8285	88	2	hypothesis	hypothesis	NN
cord-016808-gy8d8285	88	3	is	be	VBZ
cord-016808-gy8d8285	88	4	put	put	VBN
cord-016808-gy8d8285	88	5	forward	forward	RB
cord-016808-gy8d8285	88	6	according	accord	VBG
cord-016808-gy8d8285	88	7	to	to	IN
cord-016808-gy8d8285	88	8	which	which	WDT
cord-016808-gy8d8285	88	9	a	a	DT
cord-016808-gy8d8285	88	10	significant	significant	JJ
cord-016808-gy8d8285	88	11	decrease	decrease	NN
cord-016808-gy8d8285	88	12	in	in	IN
cord-016808-gy8d8285	88	13	fitness	fitness	NN
cord-016808-gy8d8285	88	14	(	(	-LRB-
cord-016808-gy8d8285	88	15	caused	cause	VBN
cord-016808-gy8d8285	88	16	for	for	IN
cord-016808-gy8d8285	88	17	example	example	NN
cord-016808-gy8d8285	88	18	by	by	IN
cord-016808-gy8d8285	88	19	mutations	mutation	NNS
cord-016808-gy8d8285	88	20	or	or	CC
cord-016808-gy8d8285	88	21	host	host	NN
cord-016808-gy8d8285	88	22	changes	change	NNS
cord-016808-gy8d8285	88	23	)	)	-RRB-
cord-016808-gy8d8285	88	24	may	may	MD
cord-016808-gy8d8285	88	25	result	result	VB
cord-016808-gy8d8285	88	26	in	in	IN
cord-016808-gy8d8285	88	27	genome	genome	NN
cord-016808-gy8d8285	88	28	instability	instability	NN
cord-016808-gy8d8285	88	29	,	,	,
cord-016808-gy8d8285	88	30	which	which	WDT
cord-016808-gy8d8285	88	31	in	in	IN
cord-016808-gy8d8285	88	32	turn	turn	NN
cord-016808-gy8d8285	88	33	would	would	MD
cord-016808-gy8d8285	88	34	produce	produce	VB
cord-016808-gy8d8285	88	35	a	a	DT
cord-016808-gy8d8285	88	36	set	set	NN
cord-016808-gy8d8285	88	37	of	of	IN
cord-016808-gy8d8285	88	38	various	various	JJ
cord-016808-gy8d8285	88	39	low	low	JJ
cord-016808-gy8d8285	88	40	-	-	HYPH
cord-016808-gy8d8285	88	41	fit	fit	JJ
cord-016808-gy8d8285	88	42	variants	variant	NNS
cord-016808-gy8d8285	88	43	.	.	.
cord-016808-gy8d8285	89	1	Under	under	IN
cord-016808-gy8d8285	89	2	non	non	JJ
cord-016808-gy8d8285	89	3	-	-	JJ
cord-016808-gy8d8285	89	4	competitive	competitive	JJ
cord-016808-gy8d8285	89	5	conditions	condition	NNS
cord-016808-gy8d8285	89	6	(	(	-LRB-
cord-016808-gy8d8285	89	7	e.g.	e.g.	RB
cord-016808-gy8d8285	89	8	,	,	,
cord-016808-gy8d8285	89	9	in	in	IN
cord-016808-gy8d8285	89	10	a	a	DT
cord-016808-gy8d8285	89	11	small	small	JJ
cord-016808-gy8d8285	89	12	-	-	HYPH
cord-016808-gy8d8285	89	13	sized	sized	JJ
cord-016808-gy8d8285	89	14	population	population	NN
cord-016808-gy8d8285	89	15	)	)	-RRB-
cord-016808-gy8d8285	89	16	,	,	,
cord-016808-gy8d8285	89	17	such	such	JJ
cord-016808-gy8d8285	89	18	variants	variant	NNS
cord-016808-gy8d8285	89	19	may	may	MD
cord-016808-gy8d8285	89	20	serve	serve	VB
cord-016808-gy8d8285	89	21	as	as	IN
cord-016808-gy8d8285	89	22	avid	avid	JJ
cord-016808-gy8d8285	89	23	acceptors	acceptor	NNS
cord-016808-gy8d8285	89	24	of	of	IN
cord-016808-gy8d8285	89	25	novel	novel	JJ
cord-016808-gy8d8285	89	26	elements	element	NNS
cord-016808-gy8d8285	89	27	acquired	acquire	VBN
cord-016808-gy8d8285	89	28	by	by	IN
cord-016808-gy8d8285	89	29	recombination	recombination	NN
cord-016808-gy8d8285	89	30	or	or	CC
cord-016808-gy8d8285	89	31	by	by	IN
cord-016808-gy8d8285	89	32	some	some	DT
cord-016808-gy8d8285	89	33	other	other	JJ
cord-016808-gy8d8285	89	34	genetic	genetic	JJ
cord-016808-gy8d8285	89	35	modifications	modification	NNS
cord-016808-gy8d8285	89	36	.	.	.
cord-016808-gy8d8285	90	1	Further	further	JJ
cord-016808-gy8d8285	90	2	fine	fine	JJ
cord-016808-gy8d8285	90	3	genetic	genetic	JJ
cord-016808-gy8d8285	90	4	tuning	tuning	NN
cord-016808-gy8d8285	90	5	may	may	MD
cord-016808-gy8d8285	90	6	convert	convert	VB
cord-016808-gy8d8285	90	7	the	the	DT
cord-016808-gy8d8285	90	8	new	new	JJ
cord-016808-gy8d8285	90	9	creature	creature	NN
cord-016808-gy8d8285	90	10	into	into	IN
cord-016808-gy8d8285	90	11	a	a	DT
cord-016808-gy8d8285	90	12	well	well	RB
cord-016808-gy8d8285	90	13	fit	fit	JJ
cord-016808-gy8d8285	90	14	new	new	JJ
cord-016808-gy8d8285	90	15	viral	viral	JJ
cord-016808-gy8d8285	90	16	species	specie	NNS
cord-016808-gy8d8285	90	17	.	.	.
cord-016808-gy8d8285	91	1	Thus	thus	RB
cord-016808-gy8d8285	91	2	,	,	,
cord-016808-gy8d8285	91	3	evolutionary	evolutionary	JJ
cord-016808-gy8d8285	91	4	"	"	``
cord-016808-gy8d8285	91	5	jumps	jump	NNS
cord-016808-gy8d8285	91	6	"	"	''
cord-016808-gy8d8285	91	7	may	may	MD
cord-016808-gy8d8285	91	8	not	not	RB
cord-016808-gy8d8285	91	9	necessarily	necessarily	RB
cord-016808-gy8d8285	91	10	be	be	VB
cord-016808-gy8d8285	91	11	due	due	JJ
cord-016808-gy8d8285	91	12	to	to	IN
cord-016808-gy8d8285	91	13	a	a	DT
cord-016808-gy8d8285	91	14	consecutive	consecutive	JJ
cord-016808-gy8d8285	91	15	acquisition	acquisition	NN
cord-016808-gy8d8285	91	16	of	of	IN
cord-016808-gy8d8285	91	17	improving	improve	VBG
cord-016808-gy8d8285	91	18	mutations	mutation	NNS
cord-016808-gy8d8285	92	1	but	but	CC
cord-016808-gy8d8285	92	2	rather	rather	RB
cord-016808-gy8d8285	92	3	they	-PRON-	PRP
cord-016808-gy8d8285	92	4	may	may	MD
cord-016808-gy8d8285	92	5	result	result	VB
cord-016808-gy8d8285	92	6	from	from	IN
cord-016808-gy8d8285	92	7	injury	injury	NN
cord-016808-gy8d8285	92	8	of	of	IN
cord-016808-gy8d8285	92	9	an	an	DT
cord-016808-gy8d8285	92	10	important	important	JJ
cord-016808-gy8d8285	92	11	element	element	NN
cord-016808-gy8d8285	92	12	followed	follow	VBN
cord-016808-gy8d8285	92	13	by	by	IN
cord-016808-gy8d8285	92	14	metastability	metastability	NN
cord-016808-gy8d8285	92	15	of	of	IN
cord-016808-gy8d8285	92	16	the	the	DT
cord-016808-gy8d8285	92	17	viral	viral	JJ
cord-016808-gy8d8285	92	18	genome	genome	NN
cord-016808-gy8d8285	92	19	,	,	,
cord-016808-gy8d8285	92	20	and	and	CC
cord-016808-gy8d8285	92	21	acquisition	acquisition	NN
cord-016808-gy8d8285	92	22	of	of	IN
cord-016808-gy8d8285	92	23	a	a	DT
cord-016808-gy8d8285	92	24	novel	novel	JJ
cord-016808-gy8d8285	92	25	element	element	NN
cord-016808-gy8d8285	92	26	.	.	.
cord-016808-gy8d8285	93	1	Viruses	virus	NNS
cord-016808-gy8d8285	93	2	are	be	VBP
cord-016808-gy8d8285	93	3	not	not	RB
cord-016808-gy8d8285	93	4	only	only	RB
cord-016808-gy8d8285	93	5	major	major	JJ
cord-016808-gy8d8285	93	6	human	human	NN
cord-016808-gy8d8285	93	7	,	,	,
cord-016808-gy8d8285	93	8	animal	animal	NN
cord-016808-gy8d8285	93	9	,	,	,
cord-016808-gy8d8285	93	10	and	and	CC
cord-016808-gy8d8285	93	11	plant	plant	NN
cord-016808-gy8d8285	93	12	pathogens	pathogen	NNS
cord-016808-gy8d8285	93	13	,	,	,
cord-016808-gy8d8285	93	14	sometime	sometime	RB
cord-016808-gy8d8285	93	15	deadly	deadly	JJ
cord-016808-gy8d8285	93	16	,	,	,
cord-016808-gy8d8285	93	17	being	be	VBG
cord-016808-gy8d8285	93	18	the	the	DT
cord-016808-gy8d8285	93	19	causative	causative	JJ
cord-016808-gy8d8285	93	20	agents	agent	NNS
cord-016808-gy8d8285	93	21	of	of	IN
cord-016808-gy8d8285	93	22	small	small	JJ
cord-016808-gy8d8285	93	23	pox	pox	NN
cord-016808-gy8d8285	93	24	,	,	,
cord-016808-gy8d8285	93	25	HIV	HIV	NNP
cord-016808-gy8d8285	93	26	,	,	,
cord-016808-gy8d8285	93	27	influenza	influenza	NN
cord-016808-gy8d8285	93	28	,	,	,
cord-016808-gy8d8285	93	29	foot	foot	NN
cord-016808-gy8d8285	93	30	-	-	HYPH
cord-016808-gy8d8285	93	31	and	and	CC
cord-016808-gy8d8285	93	32	-	-	HYPH
cord-016808-gy8d8285	93	33	mouth	mouth	NN
cord-016808-gy8d8285	93	34	disease	disease	NN
cord-016808-gy8d8285	93	35	and	and	CC
cord-016808-gy8d8285	93	36	many	many	JJ
cord-016808-gy8d8285	93	37	other	other	JJ
cord-016808-gy8d8285	93	38	severe	severe	JJ
cord-016808-gy8d8285	93	39	pathological	pathological	JJ
cord-016808-gy8d8285	93	40	conditions	condition	NNS
cord-016808-gy8d8285	93	41	,	,	,
cord-016808-gy8d8285	93	42	but	but	CC
cord-016808-gy8d8285	93	43	also	also	RB
cord-016808-gy8d8285	93	44	they	-PRON-	PRP
cord-016808-gy8d8285	93	45	are	be	VBP
cord-016808-gy8d8285	93	46	a	a	DT
cord-016808-gy8d8285	93	47	driver	driver	NN
cord-016808-gy8d8285	93	48	of	of	IN
cord-016808-gy8d8285	93	49	global	global	JJ
cord-016808-gy8d8285	93	50	geochemical	geochemical	JJ
cord-016808-gy8d8285	93	51	cycles	cycle	NNS
cord-016808-gy8d8285	93	52	through	through	IN
cord-016808-gy8d8285	93	53	killing	kill	VBG
cord-016808-gy8d8285	93	54	microplankton	microplankton	NNP
cord-016808-gy8d8285	93	55	,	,	,
cord-016808-gy8d8285	93	56	bacteria	bacteria	NNS
cord-016808-gy8d8285	93	57	etc	etc	FW
cord-016808-gy8d8285	93	58	.	.	.
cord-016808-gy8d8285	94	1	Although	although	IN
cord-016808-gy8d8285	94	2	viruses	virus	NNS
cord-016808-gy8d8285	94	3	have	have	VBP
cord-016808-gy8d8285	94	4	no	no	DT
cord-016808-gy8d8285	94	5	special	special	JJ
cord-016808-gy8d8285	94	6	"	"	``
cord-016808-gy8d8285	94	7	desire	desire	NN
cord-016808-gy8d8285	94	8	"	"	''
cord-016808-gy8d8285	94	9	to	to	TO
cord-016808-gy8d8285	94	10	hurt	hurt	VB
cord-016808-gy8d8285	94	11	the	the	DT
cord-016808-gy8d8285	94	12	host	host	NN
cord-016808-gy8d8285	94	13	cell	cell	NN
cord-016808-gy8d8285	94	14	,	,	,
cord-016808-gy8d8285	94	15	they	-PRON-	PRP
cord-016808-gy8d8285	94	16	very	very	RB
cord-016808-gy8d8285	94	17	often	often	RB
cord-016808-gy8d8285	94	18	are	be	VBP
cord-016808-gy8d8285	94	19	doing	do	VBG
cord-016808-gy8d8285	94	20	so	so	RB
cord-016808-gy8d8285	94	21	just	just	RB
cord-016808-gy8d8285	94	22	by	by	IN
cord-016808-gy8d8285	94	23	selfishness	selfishness	NN
cord-016808-gy8d8285	94	24	and	and	CC
cord-016808-gy8d8285	94	25	negligence	negligence	NN
cord-016808-gy8d8285	94	26	.	.	.
cord-016808-gy8d8285	95	1	It	-PRON-	PRP
cord-016808-gy8d8285	95	2	is	be	VBZ
cord-016808-gy8d8285	95	3	well	well	RB
cord-016808-gy8d8285	95	4	known	know	VBN
cord-016808-gy8d8285	95	5	that	that	IN
cord-016808-gy8d8285	95	6	specific	specific	JJ
cord-016808-gy8d8285	95	7	viruses	virus	NNS
cord-016808-gy8d8285	95	8	can	can	MD
cord-016808-gy8d8285	95	9	infect	infect	VB
cord-016808-gy8d8285	95	10	only	only	RB
cord-016808-gy8d8285	95	11	specific	specific	JJ
cord-016808-gy8d8285	95	12	organisms	organism	NNS
cord-016808-gy8d8285	95	13	and	and	CC
cord-016808-gy8d8285	95	14	can	can	MD
cord-016808-gy8d8285	95	15	damage	damage	VB
cord-016808-gy8d8285	95	16	in	in	IN
cord-016808-gy8d8285	95	17	these	these	DT
cord-016808-gy8d8285	95	18	organisms	organism	NNS
cord-016808-gy8d8285	95	19	only	only	RB
cord-016808-gy8d8285	95	20	specific	specific	JJ
cord-016808-gy8d8285	95	21	organs	organ	NNS
cord-016808-gy8d8285	95	22	and	and	CC
cord-016808-gy8d8285	95	23	tissues	tissue	NNS
cord-016808-gy8d8285	95	24	.	.	.
cord-016808-gy8d8285	96	1	An	an	DT
cord-016808-gy8d8285	96	2	important	important	JJ
cord-016808-gy8d8285	96	3	factor	factor	NN
cord-016808-gy8d8285	96	4	contributing	contribute	VBG
cord-016808-gy8d8285	96	5	to	to	IN
cord-016808-gy8d8285	96	6	this	this	DT
cord-016808-gy8d8285	96	7	specific	specific	JJ
cord-016808-gy8d8285	96	8	pathogenicity	pathogenicity	NN
cord-016808-gy8d8285	96	9	is	be	VBZ
cord-016808-gy8d8285	96	10	the	the	DT
cord-016808-gy8d8285	96	11	viral	viral	JJ
cord-016808-gy8d8285	96	12	host	host	NN
cord-016808-gy8d8285	96	13	range	range	NN
cord-016808-gy8d8285	96	14	,	,	,
cord-016808-gy8d8285	96	15	i.e.	i.e.	FW
cord-016808-gy8d8285	96	16	,	,	,
cord-016808-gy8d8285	96	17	the	the	DT
cord-016808-gy8d8285	96	18	ability	ability	NN
cord-016808-gy8d8285	96	19	or	or	CC
cord-016808-gy8d8285	96	20	inability	inability	NN
cord-016808-gy8d8285	96	21	to	to	TO
cord-016808-gy8d8285	96	22	infect	infect	VB
cord-016808-gy8d8285	96	23	a	a	DT
cord-016808-gy8d8285	96	24	given	give	VBN
cord-016808-gy8d8285	96	25	type	type	NN
cord-016808-gy8d8285	96	26	of	of	IN
cord-016808-gy8d8285	96	27	cells	cell	NNS
cord-016808-gy8d8285	96	28	.	.	.
cord-016808-gy8d8285	97	1	Main	main	JJ
cord-016808-gy8d8285	97	2	factors	factor	NNS
cord-016808-gy8d8285	97	3	controlling	control	VBG
cord-016808-gy8d8285	97	4	the	the	DT
cord-016808-gy8d8285	97	5	host	host	NN
cord-016808-gy8d8285	97	6	range	range	NN
cord-016808-gy8d8285	97	7	are	be	VBP
cord-016808-gy8d8285	97	8	availability	availability	NN
cord-016808-gy8d8285	97	9	of	of	IN
cord-016808-gy8d8285	97	10	appropriate	appropriate	JJ
cord-016808-gy8d8285	97	11	receptors	receptor	NNS
cord-016808-gy8d8285	97	12	on	on	IN
cord-016808-gy8d8285	97	13	the	the	DT
cord-016808-gy8d8285	97	14	cell	cell	NN
cord-016808-gy8d8285	97	15	surface	surface	NN
cord-016808-gy8d8285	97	16	,	,	,
cord-016808-gy8d8285	97	17	appropriate	appropriate	JJ
cord-016808-gy8d8285	97	18	intracellular	intracellular	JJ
cord-016808-gy8d8285	97	19	milieu	milieu	NN
cord-016808-gy8d8285	97	20	,	,	,
cord-016808-gy8d8285	97	21	and	and	CC
cord-016808-gy8d8285	97	22	status	status	NN
cord-016808-gy8d8285	97	23	of	of	IN
cord-016808-gy8d8285	97	24	the	the	DT
cord-016808-gy8d8285	97	25	innate	innate	JJ
cord-016808-gy8d8285	97	26	immunity	immunity	NN
cord-016808-gy8d8285	97	27	.	.	.
cord-016808-gy8d8285	98	1	Virus	virus	NN
cord-016808-gy8d8285	98	2	-	-	HYPH
cord-016808-gy8d8285	98	3	induced	induce	VBN
cord-016808-gy8d8285	98	4	damage	damage	NN
cord-016808-gy8d8285	98	5	to	to	IN
cord-016808-gy8d8285	98	6	cells	cell	NNS
cord-016808-gy8d8285	98	7	may	may	MD
cord-016808-gy8d8285	98	8	be	be	VB
cord-016808-gy8d8285	98	9	caused	cause	VBN
cord-016808-gy8d8285	98	10	by	by	IN
cord-016808-gy8d8285	98	11	many	many	JJ
cord-016808-gy8d8285	98	12	factors	factor	NNS
cord-016808-gy8d8285	98	13	and	and	CC
cord-016808-gy8d8285	98	14	among	among	IN
cord-016808-gy8d8285	98	15	them	-PRON-	PRP
cord-016808-gy8d8285	98	16	by	by	IN
cord-016808-gy8d8285	98	17	competition	competition	NN
cord-016808-gy8d8285	98	18	for	for	IN
cord-016808-gy8d8285	98	19	resources	resource	NNS
cord-016808-gy8d8285	98	20	and	and	CC
cord-016808-gy8d8285	98	21	for	for	IN
cord-016808-gy8d8285	98	22	cellular	cellular	JJ
cord-016808-gy8d8285	98	23	infrastructure	infrastructure	NN
cord-016808-gy8d8285	98	24	.	.	.
cord-016808-gy8d8285	99	1	The	the	DT
cord-016808-gy8d8285	99	2	outcome	outcome	NN
cord-016808-gy8d8285	99	3	of	of	IN
cord-016808-gy8d8285	99	4	infection	infection	NN
cord-016808-gy8d8285	99	5	also	also	RB
cord-016808-gy8d8285	99	6	depends	depend	VBZ
cord-016808-gy8d8285	99	7	on	on	IN
cord-016808-gy8d8285	99	8	the	the	DT
cord-016808-gy8d8285	99	9	availability	availability	NN
cord-016808-gy8d8285	99	10	of	of	IN
cord-016808-gy8d8285	99	11	viral	viral	JJ
cord-016808-gy8d8285	99	12	anti	anti	JJ
cord-016808-gy8d8285	99	13	-	-	JJ
cord-016808-gy8d8285	99	14	defensive	defensive	JJ
cord-016808-gy8d8285	99	15	mechanisms	mechanism	NNS
cord-016808-gy8d8285	99	16	.	.	.
cord-016808-gy8d8285	100	1	In	in	IN
cord-016808-gy8d8285	100	2	some	some	DT
cord-016808-gy8d8285	100	3	instances	instance	NNS
cord-016808-gy8d8285	100	4	,	,	,
cord-016808-gy8d8285	100	5	pathology	pathology	NN
cord-016808-gy8d8285	100	6	may	may	MD
cord-016808-gy8d8285	100	7	result	result	VB
cord-016808-gy8d8285	100	8	from	from	IN
cord-016808-gy8d8285	100	9	the	the	DT
cord-016808-gy8d8285	100	10	hyperactive	hyperactive	JJ
cord-016808-gy8d8285	100	11	host	host	NN
cord-016808-gy8d8285	100	12	defense	defense	NN
cord-016808-gy8d8285	100	13	.	.	.
cord-016808-gy8d8285	101	1	Killing	kill	VBG
cord-016808-gy8d8285	101	2	the	the	DT
cord-016808-gy8d8285	101	3	host	host	NN
cord-016808-gy8d8285	101	4	organism	organism	NN
cord-016808-gy8d8285	101	5	does	do	VBZ
cord-016808-gy8d8285	101	6	not	not	RB
cord-016808-gy8d8285	101	7	confer	confer	VB
cord-016808-gy8d8285	101	8	to	to	IN
cord-016808-gy8d8285	101	9	the	the	DT
cord-016808-gy8d8285	101	10	infecting	infect	VBG
cord-016808-gy8d8285	101	11	virus	virus	NN
cord-016808-gy8d8285	101	12	any	any	DT
cord-016808-gy8d8285	101	13	advantage	advantage	NN
cord-016808-gy8d8285	101	14	.	.	.
cord-016808-gy8d8285	102	1	Rather	rather	RB
cord-016808-gy8d8285	102	2	,	,	,
cord-016808-gy8d8285	102	3	co	co	NN
cord-016808-gy8d8285	102	4	-	-	NN
cord-016808-gy8d8285	102	5	evolution	evolution	NN
cord-016808-gy8d8285	102	6	of	of	IN
cord-016808-gy8d8285	102	7	viruses	virus	NNS
cord-016808-gy8d8285	102	8	and	and	CC
cord-016808-gy8d8285	102	9	hosts	host	NNS
cord-016808-gy8d8285	102	10	should	should	MD
cord-016808-gy8d8285	102	11	likely	likely	RB
cord-016808-gy8d8285	102	12	result	result	VB
cord-016808-gy8d8285	102	13	in	in	IN
cord-016808-gy8d8285	102	14	a	a	DT
cord-016808-gy8d8285	102	15	kind	kind	NN
cord-016808-gy8d8285	102	16	of	of	IN
cord-016808-gy8d8285	102	17	equilibrium	equilibrium	NN
cord-016808-gy8d8285	102	18	.	.	.
cord-016808-gy8d8285	103	1	This	this	DT
cord-016808-gy8d8285	103	2	principle	principle	NN
cord-016808-gy8d8285	103	3	may	may	MD
cord-016808-gy8d8285	103	4	be	be	VB
cord-016808-gy8d8285	103	5	illustrated	illustrate	VBN
cord-016808-gy8d8285	103	6	by	by	IN
cord-016808-gy8d8285	103	7	co	co	NN
cord-016808-gy8d8285	103	8	-	-	NN
cord-016808-gy8d8285	103	9	evolution	evolution	NN
cord-016808-gy8d8285	103	10	of	of	IN
cord-016808-gy8d8285	103	11	a	a	DT
cord-016808-gy8d8285	103	12	rabbit	rabbit	NN
cord-016808-gy8d8285	103	13	-	-	HYPH
cord-016808-gy8d8285	103	14	pathogenic	pathogenic	JJ
cord-016808-gy8d8285	103	15	virus	virus	NN
cord-016808-gy8d8285	103	16	and	and	CC
cord-016808-gy8d8285	103	17	wild	wild	JJ
cord-016808-gy8d8285	103	18	rabbits	rabbit	NNS
cord-016808-gy8d8285	103	19	in	in	IN
cord-016808-gy8d8285	103	20	Australia	Australia	NNP
cord-016808-gy8d8285	103	21	in	in	IN
cord-016808-gy8d8285	103	22	the	the	DT
cord-016808-gy8d8285	103	23	mid	mid	NN
cord-016808-gy8d8285	103	24	of	of	IN
cord-016808-gy8d8285	103	25	the	the	DT
cord-016808-gy8d8285	103	26	last	last	JJ
cord-016808-gy8d8285	103	27	century	century	NN
cord-016808-gy8d8285	103	28	(	(	-LRB-
cord-016808-gy8d8285	103	29	Fenner	Fenner	NNP
cord-016808-gy8d8285	103	30	and	and	CC
cord-016808-gy8d8285	103	31	Ratcliffe	Ratcliffe	NNP
cord-016808-gy8d8285	103	32	,	,	,
cord-016808-gy8d8285	103	33	1965	1965	CD
cord-016808-gy8d8285	103	34	)	)	-RRB-
cord-016808-gy8d8285	103	35	.	.	.
cord-016808-gy8d8285	104	1	To	to	TO
cord-016808-gy8d8285	104	2	control	control	VB
cord-016808-gy8d8285	104	3	the	the	DT
cord-016808-gy8d8285	104	4	enormous	enormous	JJ
cord-016808-gy8d8285	104	5	population	population	NN
cord-016808-gy8d8285	104	6	of	of	IN
cord-016808-gy8d8285	104	7	imported	import	VBN
cord-016808-gy8d8285	104	8	European	european	JJ
cord-016808-gy8d8285	104	9	rabbits	rabbit	NNS
cord-016808-gy8d8285	104	10	,	,	,
cord-016808-gy8d8285	104	11	which	which	WDT
cord-016808-gy8d8285	104	12	became	become	VBD
cord-016808-gy8d8285	104	13	major	major	JJ
cord-016808-gy8d8285	104	14	pests	pest	NNS
cord-016808-gy8d8285	104	15	for	for	IN
cord-016808-gy8d8285	104	16	agricultural	agricultural	JJ
cord-016808-gy8d8285	104	17	industry	industry	NN
cord-016808-gy8d8285	104	18	,	,	,
cord-016808-gy8d8285	104	19	it	-PRON-	PRP
cord-016808-gy8d8285	104	20	was	be	VBD
cord-016808-gy8d8285	104	21	decided	decide	VBN
cord-016808-gy8d8285	104	22	to	to	TO
cord-016808-gy8d8285	104	23	use	use	VB
cord-016808-gy8d8285	104	24	the	the	DT
cord-016808-gy8d8285	104	25	fibroma/	fibroma/	NNP
cord-016808-gy8d8285	104	26	myxoma	myxoma	NNP
cord-016808-gy8d8285	104	27	virus	virus	NN
cord-016808-gy8d8285	104	28	.	.	.
cord-016808-gy8d8285	105	1	This	this	DT
cord-016808-gy8d8285	105	2	virus	virus	NN
cord-016808-gy8d8285	105	3	induces	induce	VBZ
cord-016808-gy8d8285	105	4	benign	benign	JJ
cord-016808-gy8d8285	105	5	tumors	tumor	NNS
cord-016808-gy8d8285	105	6	in	in	IN
cord-016808-gy8d8285	105	7	American	american	JJ
cord-016808-gy8d8285	105	8	rabbits	rabbit	NNS
cord-016808-gy8d8285	105	9	but	but	CC
cord-016808-gy8d8285	105	10	causes	cause	NNS
cord-016808-gy8d8285	105	11	severe	severe	JJ
cord-016808-gy8d8285	105	12	generalized	generalized	JJ
cord-016808-gy8d8285	105	13	lethal	lethal	JJ
cord-016808-gy8d8285	105	14	lesions	lesion	NNS
cord-016808-gy8d8285	105	15	in	in	IN
cord-016808-gy8d8285	105	16	European	european	JJ
cord-016808-gy8d8285	105	17	ones	one	NNS
cord-016808-gy8d8285	105	18	.	.	.
cord-016808-gy8d8285	106	1	As	as	IN
cord-016808-gy8d8285	106	2	expected	expect	VBN
cord-016808-gy8d8285	106	3	,	,	,
cord-016808-gy8d8285	106	4	virus	virus	NN
cord-016808-gy8d8285	106	5	introduction	introduction	NN
cord-016808-gy8d8285	106	6	resulted	result	VBD
cord-016808-gy8d8285	106	7	in	in	IN
cord-016808-gy8d8285	106	8	mosquito	mosquito	NN
cord-016808-gy8d8285	106	9	-	-	HYPH
cord-016808-gy8d8285	106	10	borne	bear	VBN
cord-016808-gy8d8285	106	11	(	(	-LRB-
cord-016808-gy8d8285	106	12	summer	summer	NN
cord-016808-gy8d8285	106	13	)	)	-RRB-
cord-016808-gy8d8285	106	14	epizootics	epizootic	NNS
cord-016808-gy8d8285	106	15	,	,	,
cord-016808-gy8d8285	106	16	with	with	IN
cord-016808-gy8d8285	106	17	>	>	$
cord-016808-gy8d8285	106	18	99	99	CD
cord-016808-gy8d8285	106	19	%	%	NN
cord-016808-gy8d8285	106	20	of	of	IN
cord-016808-gy8d8285	106	21	the	the	DT
cord-016808-gy8d8285	106	22	infected	infected	JJ
cord-016808-gy8d8285	106	23	rabbits	rabbit	NNS
cord-016808-gy8d8285	106	24	dying	die	VBG
cord-016808-gy8d8285	106	25	in	in	IN
cord-016808-gy8d8285	106	26	less	less	JJR
cord-016808-gy8d8285	106	27	than	than	IN
cord-016808-gy8d8285	106	28	2	2	CD
cord-016808-gy8d8285	106	29	weeks	week	NNS
cord-016808-gy8d8285	106	30	.	.	.
cord-016808-gy8d8285	107	1	Naturally	naturally	RB
cord-016808-gy8d8285	107	2	occurring	occur	VBG
cord-016808-gy8d8285	107	3	less	less	RBR
cord-016808-gy8d8285	107	4	virulent	virulent	JJ
cord-016808-gy8d8285	107	5	virus	virus	NN
cord-016808-gy8d8285	107	6	variants	variant	NNS
cord-016808-gy8d8285	107	7	had	have	VBD
cord-016808-gy8d8285	107	8	more	more	JJR
cord-016808-gy8d8285	107	9	chances	chance	NNS
cord-016808-gy8d8285	107	10	for	for	IN
cord-016808-gy8d8285	107	11	overwintering	overwinter	VBG
cord-016808-gy8d8285	107	12	,	,	,
cord-016808-gy8d8285	107	13	the	the	DT
cord-016808-gy8d8285	107	14	circumstance	circumstance	NN
cord-016808-gy8d8285	107	15	resulting	result	VBG
cord-016808-gy8d8285	107	16	in	in	IN
cord-016808-gy8d8285	107	17	selection	selection	NN
cord-016808-gy8d8285	107	18	of	of	IN
cord-016808-gy8d8285	107	19	attenuated	attenuated	JJ
cord-016808-gy8d8285	107	20	viruses	virus	NNS
cord-016808-gy8d8285	107	21	.	.	.
cord-016808-gy8d8285	108	1	After	after	IN
cord-016808-gy8d8285	108	2	a	a	DT
cord-016808-gy8d8285	108	3	decade	decade	NN
cord-016808-gy8d8285	108	4	,	,	,
cord-016808-gy8d8285	108	5	the	the	DT
cord-016808-gy8d8285	108	6	mortality	mortality	NN
cord-016808-gy8d8285	108	7	of	of	IN
cord-016808-gy8d8285	108	8	European	european	JJ
cord-016808-gy8d8285	108	9	rabbits	rabbit	NNS
cord-016808-gy8d8285	108	10	in	in	IN
cord-016808-gy8d8285	108	11	Australia	Australia	NNP
cord-016808-gy8d8285	108	12	caused	cause	VBN
cord-016808-gy8d8285	108	13	by	by	IN
cord-016808-gy8d8285	108	14	the	the	DT
cord-016808-gy8d8285	108	15	evolved	evolve	VBN
cord-016808-gy8d8285	108	16	virus	virus	NN
cord-016808-gy8d8285	108	17	decreased	decrease	VBD
cord-016808-gy8d8285	108	18	roughly	roughly	RB
cord-016808-gy8d8285	108	19	two	two	CD
cord-016808-gy8d8285	108	20	-	-	HYPH
cord-016808-gy8d8285	108	21	fold	fold	NN
cord-016808-gy8d8285	108	22	.	.	.
cord-016808-gy8d8285	109	1	Simultaneously	simultaneously	RB
cord-016808-gy8d8285	109	2	,	,	,
cord-016808-gy8d8285	109	3	selection	selection	NN
cord-016808-gy8d8285	109	4	of	of	IN
cord-016808-gy8d8285	109	5	resistant	resistant	JJ
cord-016808-gy8d8285	109	6	rabbits	rabbit	NNS
cord-016808-gy8d8285	109	7	took	take	VBD
cord-016808-gy8d8285	109	8	place	place	NN
cord-016808-gy8d8285	109	9	:	:	:
cord-016808-gy8d8285	109	10	mortality	mortality	NN
cord-016808-gy8d8285	109	11	of	of	IN
cord-016808-gy8d8285	109	12	such	such	JJ
cord-016808-gy8d8285	109	13	rabbits	rabbit	NNS
cord-016808-gy8d8285	109	14	infected	infect	VBN
cord-016808-gy8d8285	109	15	with	with	IN
cord-016808-gy8d8285	109	16	the	the	DT
cord-016808-gy8d8285	109	17	original	original	JJ
cord-016808-gy8d8285	109	18	virus	virus	NN
cord-016808-gy8d8285	109	19	decreased	decrease	VBD
cord-016808-gy8d8285	109	20	roughly	roughly	RB
cord-016808-gy8d8285	109	21	fourfold	fourfold	JJ
cord-016808-gy8d8285	109	22	.	.	.
cord-016808-gy8d8285	110	1	On	on	IN
cord-016808-gy8d8285	110	2	the	the	DT
cord-016808-gy8d8285	110	3	other	other	JJ
cord-016808-gy8d8285	110	4	hand	hand	NN
cord-016808-gy8d8285	110	5	,	,	,
cord-016808-gy8d8285	110	6	newly	newly	RB
cord-016808-gy8d8285	110	7	emerging	emerge	VBG
cord-016808-gy8d8285	110	8	viral	viral	JJ
cord-016808-gy8d8285	110	9	infections	infection	NNS
cord-016808-gy8d8285	110	10	,	,	,
cord-016808-gy8d8285	110	11	caused	cause	VBN
cord-016808-gy8d8285	110	12	often	often	RB
cord-016808-gy8d8285	110	13	by	by	IN
cord-016808-gy8d8285	110	14	viruses	virus	NNS
cord-016808-gy8d8285	110	15	,	,	,
cord-016808-gy8d8285	110	16	which	which	WDT
cord-016808-gy8d8285	110	17	have	have	VBP
cord-016808-gy8d8285	110	18	been	be	VBN
cord-016808-gy8d8285	110	19	transferred	transfer	VBN
cord-016808-gy8d8285	110	20	to	to	IN
cord-016808-gy8d8285	110	21	human	human	JJ
cord-016808-gy8d8285	110	22	populations	population	NNS
cord-016808-gy8d8285	110	23	from	from	IN
cord-016808-gy8d8285	110	24	an	an	DT
cord-016808-gy8d8285	110	25	animal	animal	NN
cord-016808-gy8d8285	110	26	reservoir	reservoir	NN
cord-016808-gy8d8285	110	27	,	,	,
cord-016808-gy8d8285	110	28	may	may	MD
cord-016808-gy8d8285	110	29	exhibit	exhibit	VB
cord-016808-gy8d8285	110	30	a	a	DT
cord-016808-gy8d8285	110	31	very	very	RB
cord-016808-gy8d8285	110	32	high	high	JJ
cord-016808-gy8d8285	110	33	pathogenicity	pathogenicity	NN
cord-016808-gy8d8285	110	34	for	for	IN
cord-016808-gy8d8285	110	35	humans	human	NNS
cord-016808-gy8d8285	110	36	.	.	.
cord-016808-gy8d8285	111	1	A	a	DT
cord-016808-gy8d8285	111	2	remarkable	remarkable	JJ
cord-016808-gy8d8285	111	3	example	example	NN
cord-016808-gy8d8285	111	4	of	of	IN
cord-016808-gy8d8285	111	5	this	this	DT
cord-016808-gy8d8285	111	6	is	be	VBZ
cord-016808-gy8d8285	111	7	the	the	DT
cord-016808-gy8d8285	111	8	1918	1918	CD
cord-016808-gy8d8285	111	9	Spanish	spanish	JJ
cord-016808-gy8d8285	111	10	flu	flu	NN
cord-016808-gy8d8285	111	11	,	,	,
cord-016808-gy8d8285	111	12	which	which	WDT
cord-016808-gy8d8285	111	13	killed	kill	VBD
cord-016808-gy8d8285	111	14	about	about	RB
cord-016808-gy8d8285	111	15	30	30	CD
cord-016808-gy8d8285	111	16	-	-	SYM
cord-016808-gy8d8285	111	17	50	50	CD
cord-016808-gy8d8285	111	18	million	million	CD
cord-016808-gy8d8285	111	19	people	people	NNS
cord-016808-gy8d8285	111	20	,	,	,
cord-016808-gy8d8285	111	21	or	or	CC
cord-016808-gy8d8285	111	22	∼2	∼2	CD
cord-016808-gy8d8285	111	23	%	%	NN
cord-016808-gy8d8285	111	24	of	of	IN
cord-016808-gy8d8285	111	25	those	those	DT
cord-016808-gy8d8285	111	26	infected	infect	VBN
cord-016808-gy8d8285	111	27	.	.	.
cord-016808-gy8d8285	112	1	In	in	IN
cord-016808-gy8d8285	112	2	fact	fact	NN
cord-016808-gy8d8285	112	3	,	,	,
cord-016808-gy8d8285	112	4	influenza	influenza	NN
cord-016808-gy8d8285	112	5	virus	virus	NN
cord-016808-gy8d8285	112	6	is	be	VBZ
cord-016808-gy8d8285	112	7	in	in	IN
cord-016808-gy8d8285	112	8	most	most	JJS
cord-016808-gy8d8285	112	9	cases	case	NNS
cord-016808-gy8d8285	112	10	a	a	DT
cord-016808-gy8d8285	112	11	nonpathogenic	nonpathogenic	JJ
cord-016808-gy8d8285	112	12	or	or	CC
cord-016808-gy8d8285	112	13	slightly	slightly	RB
cord-016808-gy8d8285	112	14	pathogenic	pathogenic	JJ
cord-016808-gy8d8285	112	15	avian	avian	JJ
cord-016808-gy8d8285	112	16	enteric	enteric	JJ
cord-016808-gy8d8285	112	17	virus	virus	NN
cord-016808-gy8d8285	112	18	.	.	.
cord-016808-gy8d8285	113	1	To	to	TO
cord-016808-gy8d8285	113	2	infect	infect	VB
cord-016808-gy8d8285	113	3	a	a	DT
cord-016808-gy8d8285	113	4	human	human	NN
cord-016808-gy8d8285	113	5	,	,	,
cord-016808-gy8d8285	113	6	an	an	DT
cord-016808-gy8d8285	113	7	avian	avian	JJ
cord-016808-gy8d8285	113	8	flu	flu	NN
cord-016808-gy8d8285	113	9	virus	virus	NN
cord-016808-gy8d8285	113	10	should	should	MD
cord-016808-gy8d8285	113	11	change	change	VB
cord-016808-gy8d8285	113	12	its	-PRON-	PRP$
cord-016808-gy8d8285	113	13	receptor	receptor	NN
cord-016808-gy8d8285	113	14	specificity	specificity	NN
cord-016808-gy8d8285	113	15	,	,	,
cord-016808-gy8d8285	113	16	which	which	WDT
cord-016808-gy8d8285	113	17	depends	depend	VBZ
cord-016808-gy8d8285	113	18	on	on	IN
cord-016808-gy8d8285	113	19	the	the	DT
cord-016808-gy8d8285	113	20	interaction	interaction	NN
cord-016808-gy8d8285	113	21	of	of	IN
cord-016808-gy8d8285	113	22	viral	viral	JJ
cord-016808-gy8d8285	113	23	hemagglutinin	hemagglutinin	NN
cord-016808-gy8d8285	113	24	(	(	-LRB-
cord-016808-gy8d8285	113	25	HA	HA	NNP
cord-016808-gy8d8285	113	26	)	)	-RRB-
cord-016808-gy8d8285	113	27	with	with	IN
cord-016808-gy8d8285	113	28	a	a	DT
cord-016808-gy8d8285	113	29	cellular	cellular	JJ
cord-016808-gy8d8285	113	30	membrane	membrane	NN
cord-016808-gy8d8285	113	31	glycoprotein	glycoprotein	NN
cord-016808-gy8d8285	113	32	receptor	receptor	NN
cord-016808-gy8d8285	113	33	.	.	.
cord-016808-gy8d8285	114	1	Generally	generally	RB
cord-016808-gy8d8285	114	2	,	,	,
cord-016808-gy8d8285	114	3	it	-PRON-	PRP
cord-016808-gy8d8285	114	4	is	be	VBZ
cord-016808-gy8d8285	114	5	sufficient	sufficient	JJ
cord-016808-gy8d8285	114	6	to	to	TO
cord-016808-gy8d8285	114	7	change	change	VB
cord-016808-gy8d8285	114	8	only	only	RB
cord-016808-gy8d8285	114	9	two	two	CD
cord-016808-gy8d8285	114	10	amino	amino	NN
cord-016808-gy8d8285	114	11	acid	acid	NN
cord-016808-gy8d8285	114	12	residues	residue	NNS
cord-016808-gy8d8285	114	13	in	in	IN
cord-016808-gy8d8285	114	14	the	the	DT
cord-016808-gy8d8285	114	15	avian	avian	JJ
cord-016808-gy8d8285	114	16	HA	HA	NNP
cord-016808-gy8d8285	114	17	to	to	TO
cord-016808-gy8d8285	114	18	allow	allow	VB
cord-016808-gy8d8285	114	19	it	-PRON-	PRP
cord-016808-gy8d8285	114	20	to	to	TO
cord-016808-gy8d8285	114	21	efficiently	efficiently	RB
cord-016808-gy8d8285	114	22	recognize	recognize	VB
cord-016808-gy8d8285	114	23	the	the	DT
cord-016808-gy8d8285	114	24	human	human	JJ
cord-016808-gy8d8285	114	25	receptor	receptor	NN
cord-016808-gy8d8285	114	26	.	.	.
cord-016808-gy8d8285	115	1	Such	such	JJ
cord-016808-gy8d8285	115	2	a	a	DT
cord-016808-gy8d8285	115	3	change	change	NN
cord-016808-gy8d8285	115	4	in	in	IN
cord-016808-gy8d8285	115	5	the	the	DT
cord-016808-gy8d8285	115	6	host	host	NN
cord-016808-gy8d8285	115	7	range	range	NN
cord-016808-gy8d8285	115	8	may	may	MD
cord-016808-gy8d8285	115	9	be	be	VB
cord-016808-gy8d8285	115	10	achieved	achieve	VBN
cord-016808-gy8d8285	115	11	by	by	IN
cord-016808-gy8d8285	115	12	either	either	DT
cord-016808-gy8d8285	115	13	mutations	mutation	NNS
cord-016808-gy8d8285	115	14	in	in	IN
cord-016808-gy8d8285	115	15	the	the	DT
cord-016808-gy8d8285	115	16	avian	avian	JJ
cord-016808-gy8d8285	115	17	HA	HA	NNP
cord-016808-gy8d8285	115	18	or	or	CC
cord-016808-gy8d8285	115	19	acquisition	acquisition	NN
cord-016808-gy8d8285	115	20	by	by	IN
cord-016808-gy8d8285	115	21	an	an	DT
cord-016808-gy8d8285	115	22	avian	avian	JJ
cord-016808-gy8d8285	115	23	virus	virus	NN
cord-016808-gy8d8285	115	24	of	of	IN
cord-016808-gy8d8285	115	25	the	the	DT
cord-016808-gy8d8285	115	26	HA	HA	NNP
cord-016808-gy8d8285	115	27	gene	gene	NN
cord-016808-gy8d8285	115	28	from	from	IN
cord-016808-gy8d8285	115	29	human	human	JJ
cord-016808-gy8d8285	115	30	influenza	influenza	NN
cord-016808-gy8d8285	115	31	virus	virus	NN
cord-016808-gy8d8285	115	32	as	as	IN
cord-016808-gy8d8285	115	33	a	a	DT
cord-016808-gy8d8285	115	34	result	result	NN
cord-016808-gy8d8285	115	35	of	of	IN
cord-016808-gy8d8285	115	36	genetic	genetic	JJ
cord-016808-gy8d8285	115	37	exchange	exchange	NN
cord-016808-gy8d8285	115	38	(	(	-LRB-
cord-016808-gy8d8285	115	39	reassortment	reassortment	NN
cord-016808-gy8d8285	115	40	)	)	-RRB-
cord-016808-gy8d8285	115	41	between	between	IN
cord-016808-gy8d8285	115	42	these	these	DT
cord-016808-gy8d8285	115	43	viruses	virus	NNS
cord-016808-gy8d8285	115	44	during	during	IN
cord-016808-gy8d8285	115	45	mixed	mixed	JJ
cord-016808-gy8d8285	115	46	infections	infection	NNS
cord-016808-gy8d8285	115	47	.	.	.
cord-016808-gy8d8285	116	1	Adaptation	adaptation	NN
cord-016808-gy8d8285	116	2	of	of	IN
cord-016808-gy8d8285	116	3	flu	flu	NN
cord-016808-gy8d8285	116	4	viruses	virus	NNS
cord-016808-gy8d8285	116	5	to	to	IN
cord-016808-gy8d8285	116	6	humans	human	NNS
cord-016808-gy8d8285	116	7	may	may	MD
cord-016808-gy8d8285	116	8	also	also	RB
cord-016808-gy8d8285	116	9	require	require	VB
cord-016808-gy8d8285	116	10	mutations	mutation	NNS
cord-016808-gy8d8285	116	11	in	in	IN
cord-016808-gy8d8285	116	12	other	other	JJ
cord-016808-gy8d8285	116	13	viral	viral	JJ
cord-016808-gy8d8285	116	14	genes	gene	NNS
cord-016808-gy8d8285	116	15	.	.	.
cord-016808-gy8d8285	117	1	The	the	DT
cord-016808-gy8d8285	117	2	severity	severity	NN
cord-016808-gy8d8285	117	3	of	of	IN
cord-016808-gy8d8285	117	4	the	the	DT
cord-016808-gy8d8285	117	5	infection	infection	NN
cord-016808-gy8d8285	117	6	depends	depend	VBZ
cord-016808-gy8d8285	117	7	not	not	RB
cord-016808-gy8d8285	117	8	only	only	RB
cord-016808-gy8d8285	117	9	on	on	IN
cord-016808-gy8d8285	117	10	the	the	DT
cord-016808-gy8d8285	117	11	efficiency	efficiency	NN
cord-016808-gy8d8285	117	12	of	of	IN
cord-016808-gy8d8285	117	13	viral	viral	JJ
cord-016808-gy8d8285	117	14	reproduction	reproduction	NN
cord-016808-gy8d8285	117	15	in	in	IN
cord-016808-gy8d8285	117	16	the	the	DT
cord-016808-gy8d8285	117	17	new	new	JJ
cord-016808-gy8d8285	117	18	host	host	NN
cord-016808-gy8d8285	117	19	but	but	CC
cord-016808-gy8d8285	117	20	also	also	RB
cord-016808-gy8d8285	117	21	on	on	IN
cord-016808-gy8d8285	117	22	the	the	DT
cord-016808-gy8d8285	117	23	balance	balance	NN
cord-016808-gy8d8285	117	24	and	and	CC
cord-016808-gy8d8285	117	25	interplay	interplay	NN
cord-016808-gy8d8285	117	26	between	between	IN
cord-016808-gy8d8285	117	27	host	host	NN
cord-016808-gy8d8285	117	28	defense	defense	NN
cord-016808-gy8d8285	117	29	and	and	CC
cord-016808-gy8d8285	117	30	viral	viral	JJ
cord-016808-gy8d8285	117	31	counter	counter	JJ
cord-016808-gy8d8285	117	32	-	-	NN
cord-016808-gy8d8285	117	33	defense	defense	NN
cord-016808-gy8d8285	117	34	mechanisms	mechanism	NNS
cord-016808-gy8d8285	117	35	.	.	.
cord-016808-gy8d8285	118	1	Influenza	influenza	NN
cord-016808-gy8d8285	118	2	virus	virus	NN
cord-016808-gy8d8285	118	3	populations	population	NNS
cord-016808-gy8d8285	118	4	are	be	VBP
cord-016808-gy8d8285	118	5	constantly	constantly	RB
cord-016808-gy8d8285	118	6	changing	change	VBG
cord-016808-gy8d8285	118	7	.	.	.
cord-016808-gy8d8285	119	1	While	while	IN
cord-016808-gy8d8285	119	2	undergoing	undergo	VBG
cord-016808-gy8d8285	119	3	immune	immune	JJ
cord-016808-gy8d8285	119	4	pressure	pressure	NN
cord-016808-gy8d8285	119	5	,	,	,
cord-016808-gy8d8285	119	6	they	-PRON-	PRP
cord-016808-gy8d8285	119	7	accumulate	accumulate	VBP
cord-016808-gy8d8285	119	8	mutations	mutation	NNS
cord-016808-gy8d8285	119	9	,	,	,
cord-016808-gy8d8285	119	10	primarily	primarily	RB
cord-016808-gy8d8285	119	11	in	in	IN
cord-016808-gy8d8285	119	12	HA	HA	NNP
cord-016808-gy8d8285	119	13	and	and	CC
cord-016808-gy8d8285	119	14	neuraminidase	neuraminidase	NN
cord-016808-gy8d8285	119	15	(	(	-LRB-
cord-016808-gy8d8285	119	16	NA	NA	NNP
cord-016808-gy8d8285	119	17	)	)	-RRB-
cord-016808-gy8d8285	119	18	(	(	-LRB-
cord-016808-gy8d8285	119	19	"	"	``
cord-016808-gy8d8285	119	20	antigenic	antigenic	JJ
cord-016808-gy8d8285	119	21	drift	drift	NN
cord-016808-gy8d8285	119	22	"	"	''
cord-016808-gy8d8285	119	23	)	)	-RRB-
cord-016808-gy8d8285	119	24	.	.	.
cord-016808-gy8d8285	120	1	Qualitatively	qualitatively	RB
cord-016808-gy8d8285	120	2	new	new	JJ
cord-016808-gy8d8285	120	3	variants	variant	NNS
cord-016808-gy8d8285	120	4	are	be	VBP
cord-016808-gy8d8285	120	5	emerging	emerge	VBG
cord-016808-gy8d8285	120	6	from	from	IN
cord-016808-gy8d8285	120	7	time	time	NN
cord-016808-gy8d8285	120	8	to	to	IN
cord-016808-gy8d8285	120	9	time	time	NN
cord-016808-gy8d8285	120	10	,	,	,
cord-016808-gy8d8285	120	11	primarily	primarily	RB
cord-016808-gy8d8285	120	12	through	through	IN
cord-016808-gy8d8285	120	13	reassortment	reassortment	NN
cord-016808-gy8d8285	120	14	(	(	-LRB-
cord-016808-gy8d8285	120	15	"	"	``
cord-016808-gy8d8285	120	16	antigenic	antigenic	JJ
cord-016808-gy8d8285	120	17	shift	shift	NN
cord-016808-gy8d8285	120	18	"	"	''
cord-016808-gy8d8285	120	19	)	)	-RRB-
cord-016808-gy8d8285	120	20	.	.	.
cord-016808-gy8d8285	121	1	The	the	DT
cord-016808-gy8d8285	121	2	Spanish	spanish	JJ
cord-016808-gy8d8285	121	3	(	(	-LRB-
cord-016808-gy8d8285	121	4	1918	1918	CD
cord-016808-gy8d8285	121	5	)	)	-RRB-
cord-016808-gy8d8285	121	6	flu	flu	NN
cord-016808-gy8d8285	121	7	was	be	VBD
cord-016808-gy8d8285	121	8	just	just	RB
cord-016808-gy8d8285	121	9	one	one	CD
cord-016808-gy8d8285	121	10	of	of	IN
cord-016808-gy8d8285	121	11	such	such	JJ
cord-016808-gy8d8285	121	12	"	"	``
cord-016808-gy8d8285	121	13	shifted	shift	VBN
cord-016808-gy8d8285	121	14	"	"	''
cord-016808-gy8d8285	121	15	variants	variant	NNS
cord-016808-gy8d8285	121	16	,	,	,
cord-016808-gy8d8285	121	17	as	as	IN
cord-016808-gy8d8285	121	18	judged	judge	VBN
cord-016808-gy8d8285	121	19	by	by	IN
cord-016808-gy8d8285	121	20	the	the	DT
cord-016808-gy8d8285	121	21	nucleotide	nucleotide	JJ
cord-016808-gy8d8285	121	22	sequence	sequence	NN
cord-016808-gy8d8285	121	23	of	of	IN
cord-016808-gy8d8285	121	24	its	-PRON-	PRP$
cord-016808-gy8d8285	121	25	genomic	genomic	JJ
cord-016808-gy8d8285	121	26	RNA	RNA	NNP
cord-016808-gy8d8285	121	27	determined	determine	VBN
cord-016808-gy8d8285	121	28	from	from	IN
cord-016808-gy8d8285	121	29	archival	archival	JJ
cord-016808-gy8d8285	121	30	formalin	formalin	NN
cord-016808-gy8d8285	121	31	-	-	HYPH
cord-016808-gy8d8285	121	32	treated	treat	VBN
cord-016808-gy8d8285	121	33	paraffin	paraffin	NN
cord-016808-gy8d8285	121	34	-	-	HYPH
cord-016808-gy8d8285	121	35	embedded	embed	VBN
cord-016808-gy8d8285	121	36	as	as	RB
cord-016808-gy8d8285	121	37	well	well	RB
cord-016808-gy8d8285	121	38	as	as	IN
cord-016808-gy8d8285	121	39	permafrost	permafrost	NN
cord-016808-gy8d8285	121	40	samples	sample	NNS
cord-016808-gy8d8285	122	1	(	(	-LRB-
cord-016808-gy8d8285	122	2	Tumpey	Tumpey	NNP
cord-016808-gy8d8285	122	3	et	et	NNP
cord-016808-gy8d8285	122	4	al	al	NNP
cord-016808-gy8d8285	122	5	.	.	NNP
cord-016808-gy8d8285	122	6	,	,	,
cord-016808-gy8d8285	122	7	2005	2005	CD
cord-016808-gy8d8285	122	8	)	)	-RRB-
cord-016808-gy8d8285	122	9	.	.	.
cord-016808-gy8d8285	123	1	It	-PRON-	PRP
cord-016808-gy8d8285	123	2	was	be	VBD
cord-016808-gy8d8285	123	3	established	establish	VBN
cord-016808-gy8d8285	123	4	that	that	IN
cord-016808-gy8d8285	123	5	the	the	DT
cord-016808-gy8d8285	123	6	deadly	deadly	JJ
cord-016808-gy8d8285	123	7	virus	virus	NN
cord-016808-gy8d8285	123	8	was	be	VBD
cord-016808-gy8d8285	123	9	indeed	indeed	RB
cord-016808-gy8d8285	123	10	of	of	IN
cord-016808-gy8d8285	123	11	avian	avian	JJ
cord-016808-gy8d8285	123	12	origin	origin	NN
cord-016808-gy8d8285	123	13	and	and	CC
cord-016808-gy8d8285	123	14	that	that	IN
cord-016808-gy8d8285	123	15	the	the	DT
cord-016808-gy8d8285	123	16	"	"	``
cord-016808-gy8d8285	123	17	jump	jump	NN
cord-016808-gy8d8285	123	18	"	"	''
cord-016808-gy8d8285	123	19	into	into	IN
cord-016808-gy8d8285	123	20	humans	human	NNS
cord-016808-gy8d8285	123	21	was	be	VBD
cord-016808-gy8d8285	123	22	associated	associate	VBN
cord-016808-gy8d8285	123	23	with	with	IN
cord-016808-gy8d8285	123	24	alterations	alteration	NNS
cord-016808-gy8d8285	123	25	in	in	IN
cord-016808-gy8d8285	123	26	the	the	DT
cord-016808-gy8d8285	123	27	HA	HA	NNP
cord-016808-gy8d8285	123	28	and	and	CC
cord-016808-gy8d8285	123	29	some	some	DT
cord-016808-gy8d8285	123	30	other	other	JJ
cord-016808-gy8d8285	123	31	genes	gene	NNS
cord-016808-gy8d8285	123	32	.	.	.
cord-016808-gy8d8285	124	1	The	the	DT
cord-016808-gy8d8285	124	2	virus	virus	NN
cord-016808-gy8d8285	124	3	was	be	VBD
cord-016808-gy8d8285	124	4	reconstructed	reconstruct	VBN
cord-016808-gy8d8285	124	5	on	on	IN
cord-016808-gy8d8285	124	6	the	the	DT
cord-016808-gy8d8285	124	7	basis	basis	NN
cord-016808-gy8d8285	124	8	of	of	IN
cord-016808-gy8d8285	124	9	known	know	VBN
cord-016808-gy8d8285	124	10	nucleotide	nucleotide	JJ
cord-016808-gy8d8285	124	11	sequence	sequence	NN
cord-016808-gy8d8285	124	12	of	of	IN
cord-016808-gy8d8285	124	13	its	-PRON-	PRP$
cord-016808-gy8d8285	124	14	genome	genome	NN
cord-016808-gy8d8285	124	15	,	,	,
cord-016808-gy8d8285	124	16	and	and	CC
cord-016808-gy8d8285	124	17	its	-PRON-	PRP$
cord-016808-gy8d8285	124	18	pathogenic	pathogenic	JJ
cord-016808-gy8d8285	124	19	properties	property	NNS
cord-016808-gy8d8285	124	20	were	be	VBD
cord-016808-gy8d8285	124	21	confirmed	confirm	VBN
cord-016808-gy8d8285	124	22	and	and	CC
cord-016808-gy8d8285	124	23	further	further	RB
cord-016808-gy8d8285	124	24	investigated	investigate	VBN
cord-016808-gy8d8285	124	25	.	.	.
cord-016808-gy8d8285	125	1	The	the	DT
cord-016808-gy8d8285	125	2	causative	causative	JJ
cord-016808-gy8d8285	125	3	agents	agent	NNS
cord-016808-gy8d8285	125	4	of	of	IN
cord-016808-gy8d8285	125	5	the	the	DT
cord-016808-gy8d8285	125	6	two	two	CD
cord-016808-gy8d8285	125	7	next	next	JJ
cord-016808-gy8d8285	125	8	influenza	influenza	NN
cord-016808-gy8d8285	125	9	pandemics	pandemic	NNS
cord-016808-gy8d8285	125	10	,	,	,
cord-016808-gy8d8285	125	11	the	the	DT
cord-016808-gy8d8285	125	12	"	"	``
cord-016808-gy8d8285	125	13	Asian	asian	JJ
cord-016808-gy8d8285	125	14	"	"	''
cord-016808-gy8d8285	125	15	(	(	-LRB-
cord-016808-gy8d8285	125	16	1957	1957	CD
cord-016808-gy8d8285	125	17	)	)	-RRB-
cord-016808-gy8d8285	125	18	and	and	CC
cord-016808-gy8d8285	125	19	"	"	``
cord-016808-gy8d8285	125	20	Hong	Hong	NNP
cord-016808-gy8d8285	125	21	-	-	HYPH
cord-016808-gy8d8285	125	22	Kong	Kong	NNP
cord-016808-gy8d8285	125	23	"	"	''
cord-016808-gy8d8285	125	24	(	(	-LRB-
cord-016808-gy8d8285	125	25	1968	1968	CD
cord-016808-gy8d8285	125	26	)	)	-RRB-
cord-016808-gy8d8285	125	27	viruses	virus	NNS
cord-016808-gy8d8285	125	28	,	,	,
cord-016808-gy8d8285	125	29	also	also	RB
cord-016808-gy8d8285	125	30	resulted	result	VBD
cord-016808-gy8d8285	125	31	from	from	IN
cord-016808-gy8d8285	125	32	reassortment	reassortment	NN
cord-016808-gy8d8285	125	33	between	between	IN
cord-016808-gy8d8285	125	34	avian	avian	JJ
cord-016808-gy8d8285	125	35	and	and	CC
cord-016808-gy8d8285	125	36	human	human	JJ
cord-016808-gy8d8285	125	37	viruses	virus	NNS
cord-016808-gy8d8285	125	38	.	.	.
cord-016808-gy8d8285	126	1	Currently	currently	RB
cord-016808-gy8d8285	126	2	newly	newly	RB
cord-016808-gy8d8285	126	3	emerging	emerge	VBG
cord-016808-gy8d8285	126	4	,	,	,
cord-016808-gy8d8285	126	5	highly	highly	RB
cord-016808-gy8d8285	126	6	pathogenic	pathogenic	JJ
cord-016808-gy8d8285	126	7	avian	avian	JJ
cord-016808-gy8d8285	126	8	virus	virus	NN
cord-016808-gy8d8285	126	9	(	(	-LRB-
cord-016808-gy8d8285	126	10	H5N1	H5N1	NNP
cord-016808-gy8d8285	126	11	)	)	-RRB-
cord-016808-gy8d8285	126	12	presents	present	VBZ
cord-016808-gy8d8285	126	13	a	a	DT
cord-016808-gy8d8285	126	14	potential	potential	JJ
cord-016808-gy8d8285	126	15	threat	threat	NN
cord-016808-gy8d8285	126	16	of	of	IN
cord-016808-gy8d8285	126	17	a	a	DT
cord-016808-gy8d8285	126	18	new	new	JJ
cord-016808-gy8d8285	126	19	pandemic	pandemic	NN
cord-016808-gy8d8285	126	20	.	.	.
cord-016808-gy8d8285	127	1	Although	although	IN
cord-016808-gy8d8285	127	2	cases	case	NNS
cord-016808-gy8d8285	127	3	of	of	IN
cord-016808-gy8d8285	127	4	human	human	NN
cord-016808-gy8d8285	127	5	-	-	HYPH
cord-016808-gy8d8285	127	6	to	to	IN
cord-016808-gy8d8285	127	7	-	-	HYPH
cord-016808-gy8d8285	127	8	human	human	JJ
cord-016808-gy8d8285	127	9	transmission	transmission	NN
cord-016808-gy8d8285	127	10	of	of	IN
cord-016808-gy8d8285	127	11	this	this	DT
cord-016808-gy8d8285	127	12	virus	virus	NN
cord-016808-gy8d8285	127	13	are	be	VBP
cord-016808-gy8d8285	127	14	so	so	RB
cord-016808-gy8d8285	127	15	far	far	RB
cord-016808-gy8d8285	127	16	extremely	extremely	RB
cord-016808-gy8d8285	127	17	rare	rare	JJ
cord-016808-gy8d8285	127	18	and	and	CC
cord-016808-gy8d8285	127	19	only	only	RB
cord-016808-gy8d8285	127	20	occur	occur	VBP
cord-016808-gy8d8285	127	21	during	during	IN
cord-016808-gy8d8285	127	22	close	close	JJ
cord-016808-gy8d8285	127	23	family	family	NN
cord-016808-gy8d8285	127	24	contacts	contact	NNS
cord-016808-gy8d8285	127	25	,	,	,
cord-016808-gy8d8285	127	26	the	the	DT
cord-016808-gy8d8285	127	27	possibility	possibility	NN
cord-016808-gy8d8285	127	28	of	of	IN
cord-016808-gy8d8285	127	29	acquisition	acquisition	NN
cord-016808-gy8d8285	127	30	of	of	IN
cord-016808-gy8d8285	127	31	ominous	ominous	JJ
cord-016808-gy8d8285	127	32	mutations	mutation	NNS
cord-016808-gy8d8285	127	33	can	can	MD
cord-016808-gy8d8285	127	34	not	not	RB
cord-016808-gy8d8285	127	35	be	be	VB
cord-016808-gy8d8285	127	36	ruled	rule	VBN
cord-016808-gy8d8285	127	37	out	out	RP
cord-016808-gy8d8285	127	38	.	.	.
cord-016808-gy8d8285	128	1	The	the	DT
cord-016808-gy8d8285	128	2	severe	severe	JJ
cord-016808-gy8d8285	128	3	acute	acute	JJ
cord-016808-gy8d8285	128	4	respiratory	respiratory	JJ
cord-016808-gy8d8285	128	5	syndrome	syndrome	NN
cord-016808-gy8d8285	128	6	(	(	-LRB-
cord-016808-gy8d8285	128	7	SARS	SARS	NNP
cord-016808-gy8d8285	128	8	)	)	-RRB-
cord-016808-gy8d8285	128	9	is	be	VBZ
cord-016808-gy8d8285	128	10	caused	cause	VBN
cord-016808-gy8d8285	128	11	by	by	IN
cord-016808-gy8d8285	128	12	another	another	DT
cord-016808-gy8d8285	128	13	newly	newly	RB
cord-016808-gy8d8285	128	14	emerged	emerge	VBN
cord-016808-gy8d8285	128	15	virus	virus	NN
cord-016808-gy8d8285	128	16	.	.	.
cord-016808-gy8d8285	129	1	It	-PRON-	PRP
cord-016808-gy8d8285	129	2	belongs	belong	VBZ
cord-016808-gy8d8285	129	3	to	to	IN
cord-016808-gy8d8285	129	4	coronaviruses	coronaviruse	NNS
cord-016808-gy8d8285	129	5	.	.	.
cord-016808-gy8d8285	130	1	Representatives	representative	NNS
cord-016808-gy8d8285	130	2	of	of	IN
cord-016808-gy8d8285	130	3	this	this	DT
cord-016808-gy8d8285	130	4	viral	viral	JJ
cord-016808-gy8d8285	130	5	family	family	NN
cord-016808-gy8d8285	130	6	are	be	VBP
cord-016808-gy8d8285	130	7	etiological	etiological	JJ
cord-016808-gy8d8285	130	8	agents	agent	NNS
cord-016808-gy8d8285	130	9	of	of	IN
cord-016808-gy8d8285	130	10	relatively	relatively	RB
cord-016808-gy8d8285	130	11	mild	mild	JJ
cord-016808-gy8d8285	130	12	respiratory	respiratory	NN
cord-016808-gy8d8285	130	13	(	(	-LRB-
cord-016808-gy8d8285	130	14	e.g.	e.g.	RB
cord-016808-gy8d8285	130	15	,	,	,
cord-016808-gy8d8285	130	16	common	common	JJ
cord-016808-gy8d8285	130	17	cold	cold	NN
cord-016808-gy8d8285	130	18	)	)	-RRB-
cord-016808-gy8d8285	130	19	,	,	,
cord-016808-gy8d8285	130	20	enteric	enteric	JJ
cord-016808-gy8d8285	130	21	,	,	,
cord-016808-gy8d8285	130	22	and	and	CC
cord-016808-gy8d8285	130	23	some	some	DT
cord-016808-gy8d8285	130	24	other	other	JJ
cord-016808-gy8d8285	130	25	diseases	disease	NNS
cord-016808-gy8d8285	130	26	in	in	IN
cord-016808-gy8d8285	130	27	a	a	DT
cord-016808-gy8d8285	130	28	wide	wide	JJ
cord-016808-gy8d8285	130	29	variety	variety	NN
cord-016808-gy8d8285	130	30	of	of	IN
cord-016808-gy8d8285	130	31	animals	animal	NNS
cord-016808-gy8d8285	130	32	and	and	CC
cord-016808-gy8d8285	130	33	humans	human	NNS
cord-016808-gy8d8285	130	34	.	.	.
cord-016808-gy8d8285	131	1	Again	again	RB
cord-016808-gy8d8285	131	2	,	,	,
cord-016808-gy8d8285	131	3	the	the	DT
cord-016808-gy8d8285	131	4	very	very	RB
cord-016808-gy8d8285	131	5	dangerous	dangerous	JJ
cord-016808-gy8d8285	131	6	virus	virus	NN
cord-016808-gy8d8285	131	7	"	"	''
cord-016808-gy8d8285	131	8	came	come	VBD
cord-016808-gy8d8285	131	9	"	"	''
cord-016808-gy8d8285	131	10	to	to	IN
cord-016808-gy8d8285	131	11	humans	human	NNS
cord-016808-gy8d8285	131	12	from	from	IN
cord-016808-gy8d8285	131	13	an	an	DT
cord-016808-gy8d8285	131	14	animal	animal	NN
cord-016808-gy8d8285	131	15	(	(	-LRB-
cord-016808-gy8d8285	131	16	in	in	IN
cord-016808-gy8d8285	131	17	this	this	DT
cord-016808-gy8d8285	131	18	case	case	NN
cord-016808-gy8d8285	131	19	,	,	,
cord-016808-gy8d8285	131	20	bat	bat	NN
cord-016808-gy8d8285	131	21	)	)	-RRB-
cord-016808-gy8d8285	131	22	and	and	CC
cord-016808-gy8d8285	131	23	the	the	DT
cord-016808-gy8d8285	131	24	interspecies	interspecie	NNS
cord-016808-gy8d8285	131	25	transmission	transmission	NN
cord-016808-gy8d8285	131	26	involved	involve	VBD
cord-016808-gy8d8285	131	27	a	a	DT
cord-016808-gy8d8285	131	28	change	change	NN
cord-016808-gy8d8285	131	29	in	in	IN
cord-016808-gy8d8285	131	30	receptor	receptor	NN
cord-016808-gy8d8285	131	31	recognition	recognition	NN
cord-016808-gy8d8285	132	1	(	(	-LRB-
cord-016808-gy8d8285	132	2	Lau	Lau	NNP
cord-016808-gy8d8285	132	3	et	et	NNP
cord-016808-gy8d8285	132	4	al	al	NNP
cord-016808-gy8d8285	132	5	.	.	NNP
cord-016808-gy8d8285	132	6	,	,	,
cord-016808-gy8d8285	132	7	2005	2005	CD
cord-016808-gy8d8285	132	8	;	;	:
cord-016808-gy8d8285	132	9	Li	Li	NNP
cord-016808-gy8d8285	132	10	et	et	NNP
cord-016808-gy8d8285	132	11	al	al	NNP
cord-016808-gy8d8285	132	12	.	.	NNP
cord-016808-gy8d8285	132	13	,	,	,
cord-016808-gy8d8285	132	14	2005	2005	CD
cord-016808-gy8d8285	132	15	)	)	-RRB-
cord-016808-gy8d8285	132	16	.	.	.
cord-016808-gy8d8285	133	1	The	the	DT
cord-016808-gy8d8285	133	2	human	human	JJ
cord-016808-gy8d8285	133	3	immunodeficiency	immunodeficiency	NN
cord-016808-gy8d8285	133	4	viruses	virus	NNS
cord-016808-gy8d8285	133	5	(	(	-LRB-
cord-016808-gy8d8285	133	6	HIV	HIV	NNP
cord-016808-gy8d8285	133	7	)	)	-RRB-
cord-016808-gy8d8285	133	8	originated	originate	VBD
cord-016808-gy8d8285	133	9	from	from	IN
cord-016808-gy8d8285	133	10	simian	simian	JJ
cord-016808-gy8d8285	133	11	immunodeficiency	immunodeficiency	NN
cord-016808-gy8d8285	133	12	viruses	virus	NNS
cord-016808-gy8d8285	133	13	(	(	-LRB-
cord-016808-gy8d8285	133	14	SIV	SIV	NNP
cord-016808-gy8d8285	133	15	)	)	-RRB-
cord-016808-gy8d8285	133	16	.	.	.
cord-016808-gy8d8285	134	1	SIVs	siv	NNS
cord-016808-gy8d8285	134	2	are	be	VBP
cord-016808-gy8d8285	134	3	viruses	virus	NNS
cord-016808-gy8d8285	134	4	that	that	WDT
cord-016808-gy8d8285	134	5	infect	infect	VBP
cord-016808-gy8d8285	134	6	some	some	DT
cord-016808-gy8d8285	134	7	40	40	CD
cord-016808-gy8d8285	134	8	different	different	JJ
cord-016808-gy8d8285	134	9	nonhuman	nonhuman	NN
cord-016808-gy8d8285	134	10	primate	primate	NN
cord-016808-gy8d8285	134	11	species	specie	NNS
cord-016808-gy8d8285	134	12	in	in	IN
cord-016808-gy8d8285	134	13	sub	sub	JJ
cord-016808-gy8d8285	134	14	-	-	JJ
cord-016808-gy8d8285	134	15	Saharan	saharan	JJ
cord-016808-gy8d8285	134	16	Africa	Africa	NNP
cord-016808-gy8d8285	134	17	.	.	.
cord-016808-gy8d8285	135	1	Primates	primate	NNS
cord-016808-gy8d8285	135	2	naturally	naturally	RB
cord-016808-gy8d8285	135	3	infected	infect	VBN
cord-016808-gy8d8285	135	4	with	with	IN
cord-016808-gy8d8285	135	5	SIV	SIV	NNP
cord-016808-gy8d8285	135	6	do	do	VBP
cord-016808-gy8d8285	135	7	not	not	RB
cord-016808-gy8d8285	135	8	appear	appear	VB
cord-016808-gy8d8285	135	9	to	to	TO
cord-016808-gy8d8285	135	10	develop	develop	VB
cord-016808-gy8d8285	135	11	immunodeficiency	immunodeficiency	NN
cord-016808-gy8d8285	135	12	.	.	.
cord-016808-gy8d8285	136	1	The	the	DT
cord-016808-gy8d8285	136	2	immediate	immediate	JJ
cord-016808-gy8d8285	136	3	precursor	precursor	NN
cord-016808-gy8d8285	136	4	of	of	IN
cord-016808-gy8d8285	136	5	HIV-1	HIV-1	NNP
cord-016808-gy8d8285	136	6	was	be	VBD
cord-016808-gy8d8285	136	7	a	a	DT
cord-016808-gy8d8285	136	8	virus	virus	NN
cord-016808-gy8d8285	136	9	,	,	,
cord-016808-gy8d8285	136	10	SIVcpz	SIVcpz	NNP
cord-016808-gy8d8285	136	11	,	,	,
cord-016808-gy8d8285	136	12	which	which	WDT
cord-016808-gy8d8285	136	13	infects	infect	VBZ
cord-016808-gy8d8285	136	14	chimpanzees	chimpanzee	NNS
cord-016808-gy8d8285	136	15	of	of	IN
cord-016808-gy8d8285	136	16	the	the	DT
cord-016808-gy8d8285	136	17	subspecies	subspecies	NN
cord-016808-gy8d8285	136	18	Pan	Pan	NNP
cord-016808-gy8d8285	136	19	troglodytes	troglodyte	NNS
cord-016808-gy8d8285	136	20	troglodytes	troglodyte	NNS
cord-016808-gy8d8285	136	21	in	in	IN
cord-016808-gy8d8285	136	22	West	West	NNP
cord-016808-gy8d8285	136	23	Central	Central	NNP
cord-016808-gy8d8285	136	24	Africa	Africa	NNP
cord-016808-gy8d8285	136	25	.	.	.
cord-016808-gy8d8285	137	1	Interestingly	interestingly	RB
cord-016808-gy8d8285	137	2	,	,	,
cord-016808-gy8d8285	137	3	SIVcpz	sivcpz	NN
cord-016808-gy8d8285	137	4	strains	strain	NNS
cord-016808-gy8d8285	137	5	have	have	VBP
cord-016808-gy8d8285	137	6	been	be	VBN
cord-016808-gy8d8285	137	7	transmitted	transmit	VBN
cord-016808-gy8d8285	137	8	from	from	IN
cord-016808-gy8d8285	137	9	chimps	chimp	NNS
cord-016808-gy8d8285	137	10	to	to	IN
cord-016808-gy8d8285	137	11	humans	human	NNS
cord-016808-gy8d8285	137	12	on	on	IN
cord-016808-gy8d8285	137	13	at	at	RB
cord-016808-gy8d8285	137	14	least	least	RBS
cord-016808-gy8d8285	137	15	three	three	CD
cord-016808-gy8d8285	137	16	independent	independent	JJ
cord-016808-gy8d8285	137	17	occasions	occasion	NNS
cord-016808-gy8d8285	137	18	,	,	,
cord-016808-gy8d8285	137	19	with	with	IN
cord-016808-gy8d8285	137	20	the	the	DT
cord-016808-gy8d8285	137	21	current	current	JJ
cord-016808-gy8d8285	137	22	HIV-1	HIV-1	NNP
cord-016808-gy8d8285	137	23	group	group	NN
cord-016808-gy8d8285	137	24	M	M	NNP
cord-016808-gy8d8285	137	25	pandemic	pandemic	NN
cord-016808-gy8d8285	137	26	strain	strain	NN
cord-016808-gy8d8285	137	27	(	(	-LRB-
cord-016808-gy8d8285	137	28	>	>	NFP
cord-016808-gy8d8285	137	29	60	60	CD
cord-016808-gy8d8285	137	30	million	million	CD
cord-016808-gy8d8285	137	31	people	people	NNS
cord-016808-gy8d8285	137	32	infected	infect	VBN
cord-016808-gy8d8285	137	33	,	,	,
cord-016808-gy8d8285	137	34	>	>	XX
cord-016808-gy8d8285	137	35	20	20	CD
cord-016808-gy8d8285	137	36	million	million	CD
cord-016808-gy8d8285	137	37	deaths	death	NNS
cord-016808-gy8d8285	137	38	)	)	-RRB-
cord-016808-gy8d8285	137	39	resulting	result	VBG
cord-016808-gy8d8285	137	40	from	from	IN
cord-016808-gy8d8285	137	41	just	just	RB
cord-016808-gy8d8285	137	42	one	one	CD
cord-016808-gy8d8285	137	43	of	of	IN
cord-016808-gy8d8285	137	44	these	these	DT
cord-016808-gy8d8285	137	45	transmissions	transmission	NNS
cord-016808-gy8d8285	137	46	.	.	.
cord-016808-gy8d8285	138	1	The	the	DT
cord-016808-gy8d8285	138	2	trans	trans	JJ
cord-016808-gy8d8285	138	3	-	-	JJ
cord-016808-gy8d8285	138	4	species	species	JJ
cord-016808-gy8d8285	138	5	transmission	transmission	NN
cord-016808-gy8d8285	138	6	appeared	appear	VBD
cord-016808-gy8d8285	138	7	to	to	TO
cord-016808-gy8d8285	138	8	require	require	VB
cord-016808-gy8d8285	138	9	multiple	multiple	JJ
cord-016808-gy8d8285	138	10	adaptation	adaptation	NN
cord-016808-gy8d8285	138	11	events	event	NNS
cord-016808-gy8d8285	138	12	,	,	,
cord-016808-gy8d8285	138	13	such	such	JJ
cord-016808-gy8d8285	138	14	as	as	IN
cord-016808-gy8d8285	138	15	changed	change	VBN
cord-016808-gy8d8285	138	16	transmission	transmission	NN
cord-016808-gy8d8285	138	17	mode	mode	NN
cord-016808-gy8d8285	138	18	(	(	-LRB-
cord-016808-gy8d8285	138	19	from	from	IN
cord-016808-gy8d8285	138	20	bite	bite	NN
cord-016808-gy8d8285	138	21	/	/	SYM
cord-016808-gy8d8285	138	22	wounds	wound	NNS
cord-016808-gy8d8285	138	23	to	to	IN
cord-016808-gy8d8285	138	24	sexual	sexual	JJ
cord-016808-gy8d8285	138	25	)	)	-RRB-
cord-016808-gy8d8285	138	26	,	,	,
cord-016808-gy8d8285	138	27	adaptation	adaptation	NN
cord-016808-gy8d8285	138	28	to	to	IN
cord-016808-gy8d8285	138	29	receptors	receptor	NNS
cord-016808-gy8d8285	138	30	and	and	CC
cord-016808-gy8d8285	138	31	overcoming	overcome	VBG
cord-016808-gy8d8285	138	32	some	some	DT
cord-016808-gy8d8285	138	33	post	post	JJ
cord-016808-gy8d8285	138	34	-	-	JJ
cord-016808-gy8d8285	138	35	entry	entry	JJ
cord-016808-gy8d8285	138	36	barriers	barrier	NNS
cord-016808-gy8d8285	138	37	(	(	-LRB-
cord-016808-gy8d8285	138	38	Gao	Gao	NNP
cord-016808-gy8d8285	138	39	et	et	NNP
cord-016808-gy8d8285	138	40	al	al	NNP
cord-016808-gy8d8285	138	41	.	.	NNP
cord-016808-gy8d8285	138	42	,	,	,
cord-016808-gy8d8285	138	43	1999	1999	CD
cord-016808-gy8d8285	138	44	;	;	:
cord-016808-gy8d8285	138	45	Heeney	Heeney	NNP
cord-016808-gy8d8285	138	46	et	et	NNP
cord-016808-gy8d8285	138	47	al	al	NNP
cord-016808-gy8d8285	138	48	.	.	NNP
cord-016808-gy8d8285	138	49	,	,	,
cord-016808-gy8d8285	138	50	2006	2006	CD
cord-016808-gy8d8285	138	51	)	)	-RRB-
cord-016808-gy8d8285	138	52	.	.	.
cord-016808-gy8d8285	139	1	In	in	IN
cord-016808-gy8d8285	139	2	human	human	JJ
cord-016808-gy8d8285	139	3	populations	population	NNS
cord-016808-gy8d8285	139	4	and	and	CC
cord-016808-gy8d8285	139	5	individuals	individual	NNS
cord-016808-gy8d8285	139	6	,	,	,
cord-016808-gy8d8285	139	7	HIV	HIV	NNP
cord-016808-gy8d8285	139	8	is	be	VBZ
cord-016808-gy8d8285	139	9	rapidly	rapidly	RB
cord-016808-gy8d8285	139	10	evolving	evolve	VBG
cord-016808-gy8d8285	139	11	by	by	IN
cord-016808-gy8d8285	139	12	mutations	mutation	NNS
cord-016808-gy8d8285	139	13	and	and	CC
cord-016808-gy8d8285	139	14	recombination	recombination	NN
cord-016808-gy8d8285	139	15	,	,	,
cord-016808-gy8d8285	139	16	making	make	VBG
cord-016808-gy8d8285	139	17	antiviral	antiviral	JJ
cord-016808-gy8d8285	139	18	therapy	therapy	NN
cord-016808-gy8d8285	139	19	a	a	DT
cord-016808-gy8d8285	139	20	very	very	RB
cord-016808-gy8d8285	139	21	difficult	difficult	JJ
cord-016808-gy8d8285	139	22	job	job	NN
cord-016808-gy8d8285	139	23	.	.	.
cord-016808-gy8d8285	140	1	Major	major	JJ
cord-016808-gy8d8285	140	2	lessons	lesson	NNS
cord-016808-gy8d8285	140	3	derived	derive	VBN
cord-016808-gy8d8285	140	4	from	from	IN
cord-016808-gy8d8285	140	5	studies	study	NNS
cord-016808-gy8d8285	140	6	of	of	IN
cord-016808-gy8d8285	140	7	emerging	emerge	VBG
cord-016808-gy8d8285	140	8	viral	viral	JJ
cord-016808-gy8d8285	140	9	infections	infection	NNS
cord-016808-gy8d8285	140	10	are	be	VBP
cord-016808-gy8d8285	140	11	as	as	IN
cord-016808-gy8d8285	140	12	follows	follow	VBZ
cord-016808-gy8d8285	140	13	.	.	.
cord-016808-gy8d8285	141	1	New	new	JJ
cord-016808-gy8d8285	141	2	human	human	JJ
cord-016808-gy8d8285	141	3	pathogenic	pathogenic	JJ
cord-016808-gy8d8285	141	4	viruses	virus	NNS
cord-016808-gy8d8285	141	5	are	be	VBP
cord-016808-gy8d8285	141	6	usually	usually	RB
cord-016808-gy8d8285	141	7	originating	originate	VBG
cord-016808-gy8d8285	141	8	from	from	IN
cord-016808-gy8d8285	141	9	relatively	relatively	RB
cord-016808-gy8d8285	141	10	low	low	JJ
cord-016808-gy8d8285	141	11	pathogenic	pathogenic	JJ
cord-016808-gy8d8285	141	12	animal	animal	NN
cord-016808-gy8d8285	141	13	viruses	virus	NNS
cord-016808-gy8d8285	141	14	by	by	IN
cord-016808-gy8d8285	141	15	changing	change	VBG
cord-016808-gy8d8285	141	16	host	host	NN
cord-016808-gy8d8285	141	17	range	range	NN
cord-016808-gy8d8285	141	18	(	(	-LRB-
cord-016808-gy8d8285	141	19	crossing	cross	VBG
cord-016808-gy8d8285	141	20	interspecies	interspecie	NNS
cord-016808-gy8d8285	141	21	barrier	barrier	NN
cord-016808-gy8d8285	141	22	)	)	-RRB-
cord-016808-gy8d8285	141	23	.	.	.
cord-016808-gy8d8285	142	1	They	-PRON-	PRP
cord-016808-gy8d8285	142	2	may	may	MD
cord-016808-gy8d8285	142	3	become	become	VB
cord-016808-gy8d8285	142	4	highly	highly	RB
cord-016808-gy8d8285	142	5	pathogenic	pathogenic	JJ
cord-016808-gy8d8285	142	6	in	in	IN
cord-016808-gy8d8285	142	7	humans	human	NNS
cord-016808-gy8d8285	142	8	,	,	,
cord-016808-gy8d8285	142	9	in	in	IN
cord-016808-gy8d8285	142	10	particular	particular	JJ
cord-016808-gy8d8285	142	11	,	,	,
cord-016808-gy8d8285	142	12	because	because	IN
cord-016808-gy8d8285	142	13	they	-PRON-	PRP
cord-016808-gy8d8285	142	14	,	,	,
cord-016808-gy8d8285	142	15	as	as	IN
cord-016808-gy8d8285	142	16	unknown	unknown	JJ
cord-016808-gy8d8285	142	17	invaders	invader	NNS
cord-016808-gy8d8285	142	18	,	,	,
cord-016808-gy8d8285	142	19	are	be	VBP
cord-016808-gy8d8285	142	20	met	meet	VBN
cord-016808-gy8d8285	142	21	with	with	IN
cord-016808-gy8d8285	142	22	a	a	DT
cord-016808-gy8d8285	142	23	hyper	hyper	JJ
cord-016808-gy8d8285	142	24	-	-	JJ
cord-016808-gy8d8285	142	25	reactive	reactive	JJ
cord-016808-gy8d8285	142	26	defense	defense	NN
cord-016808-gy8d8285	142	27	reaction	reaction	NN
cord-016808-gy8d8285	142	28	leading	lead	VBG
cord-016808-gy8d8285	142	29	to	to	IN
cord-016808-gy8d8285	142	30	extensive	extensive	JJ
cord-016808-gy8d8285	142	31	host	host	NN
cord-016808-gy8d8285	142	32	damage	damage	NN
cord-016808-gy8d8285	142	33	,	,	,
cord-016808-gy8d8285	142	34	whereas	whereas	IN
cord-016808-gy8d8285	142	35	the	the	DT
cord-016808-gy8d8285	142	36	viruses	virus	NNS
cord-016808-gy8d8285	142	37	carelessly	carelessly	RB
cord-016808-gy8d8285	142	38	employ	employ	VBP
cord-016808-gy8d8285	142	39	in	in	IN
cord-016808-gy8d8285	142	40	full	full	JJ
cord-016808-gy8d8285	142	41	their	-PRON-	PRP$
cord-016808-gy8d8285	142	42	anti	anti	JJ
cord-016808-gy8d8285	142	43	-	-	JJ
cord-016808-gy8d8285	142	44	defensive	defensive	JJ
cord-016808-gy8d8285	142	45	tools	tool	NNS
cord-016808-gy8d8285	142	46	.	.	.
cord-016808-gy8d8285	143	1	Further	further	JJ
cord-016808-gy8d8285	143	2	rapid	rapid	JJ
cord-016808-gy8d8285	143	3	evolutionary	evolutionary	JJ
cord-016808-gy8d8285	143	4	rates	rate	NNS
cord-016808-gy8d8285	143	5	may	may	MD
cord-016808-gy8d8285	143	6	contribute	contribute	VB
cord-016808-gy8d8285	143	7	to	to	IN
cord-016808-gy8d8285	143	8	difficulty	difficulty	NN
cord-016808-gy8d8285	143	9	in	in	IN
cord-016808-gy8d8285	143	10	combating	combat	VBG
cord-016808-gy8d8285	143	11	these	these	DT
cord-016808-gy8d8285	143	12	infections	infection	NNS
cord-016808-gy8d8285	143	13	.	.	.
cord-016808-gy8d8285	144	1	On	on	IN
cord-016808-gy8d8285	144	2	the	the	DT
cord-016808-gy8d8285	144	3	other	other	JJ
cord-016808-gy8d8285	144	4	hand	hand	NN
cord-016808-gy8d8285	144	5	,	,	,
cord-016808-gy8d8285	144	6	long	long	JJ
cord-016808-gy8d8285	144	7	-	-	HYPH
cord-016808-gy8d8285	144	8	term	term	NN
cord-016808-gy8d8285	144	9	evolution	evolution	NN
cord-016808-gy8d8285	144	10	of	of	IN
cord-016808-gy8d8285	144	11	such	such	JJ
cord-016808-gy8d8285	144	12	viruses	virus	NNS
cord-016808-gy8d8285	144	13	may	may	MD
cord-016808-gy8d8285	144	14	lead	lead	VB
cord-016808-gy8d8285	144	15	to	to	IN
cord-016808-gy8d8285	144	16	a	a	DT
cord-016808-gy8d8285	144	17	decrease	decrease	NN
cord-016808-gy8d8285	144	18	in	in	IN
cord-016808-gy8d8285	144	19	their	-PRON-	PRP$
cord-016808-gy8d8285	144	20	pathogenicity	pathogenicity	NN
cord-016808-gy8d8285	144	21	and	and	CC
cord-016808-gy8d8285	144	22	human	human	JJ
cord-016808-gy8d8285	144	23	evolution	evolution	NN
cord-016808-gy8d8285	144	24	may	may	MD
cord-016808-gy8d8285	144	25	probably	probably	RB
cord-016808-gy8d8285	144	26	result	result	VB
cord-016808-gy8d8285	144	27	in	in	IN
cord-016808-gy8d8285	144	28	an	an	DT
cord-016808-gy8d8285	144	29	increased	increase	VBN
cord-016808-gy8d8285	144	30	resistance	resistance	NN
cord-016808-gy8d8285	144	31	to	to	IN
cord-016808-gy8d8285	144	32	such	such	JJ
cord-016808-gy8d8285	144	33	viruses	virus	NNS
cord-016808-gy8d8285	144	34	.	.	.
cord-016808-gy8d8285	145	1	We	-PRON-	PRP
cord-016808-gy8d8285	145	2	may	may	MD
cord-016808-gy8d8285	145	3	blame	blame	VB
cord-016808-gy8d8285	145	4	viruses	virus	NNS
cord-016808-gy8d8285	145	5	for	for	IN
cord-016808-gy8d8285	145	6	severe	severe	JJ
cord-016808-gy8d8285	145	7	diseases	disease	NNS
cord-016808-gy8d8285	145	8	and	and	CC
cord-016808-gy8d8285	145	9	even	even	RB
cord-016808-gy8d8285	145	10	should	should	MD
cord-016808-gy8d8285	145	11	actively	actively	RB
cord-016808-gy8d8285	145	12	combat	combat	VB
cord-016808-gy8d8285	145	13	them	-PRON-	PRP
cord-016808-gy8d8285	146	1	but	but	CC
cord-016808-gy8d8285	146	2	we	-PRON-	PRP
cord-016808-gy8d8285	146	3	should	should	MD
cord-016808-gy8d8285	146	4	never	never	RB
cord-016808-gy8d8285	146	5	forget	forget	VB
cord-016808-gy8d8285	146	6	that	that	IN
cord-016808-gy8d8285	146	7	we	-PRON-	PRP
cord-016808-gy8d8285	146	8	owe	owe	VBP
cord-016808-gy8d8285	146	9	to	to	IN
cord-016808-gy8d8285	146	10	viruses	virus	NNS
cord-016808-gy8d8285	146	11	very	very	RB
cord-016808-gy8d8285	146	12	much	much	RB
cord-016808-gy8d8285	146	13	for	for	IN
cord-016808-gy8d8285	146	14	the	the	DT
cord-016808-gy8d8285	146	15	existence	existence	NN
cord-016808-gy8d8285	146	16	of	of	IN
cord-016808-gy8d8285	146	17	the	the	DT
cord-016808-gy8d8285	146	18	live	live	JJ
cord-016808-gy8d8285	146	19	Nature	nature	NN
cord-016808-gy8d8285	146	20	and	and	CC
cord-016808-gy8d8285	146	21	for	for	IN
cord-016808-gy8d8285	146	22	our	-PRON-	PRP$
cord-016808-gy8d8285	146	23	own	own	JJ
cord-016808-gy8d8285	146	24	existence	existence	NN
cord-016808-gy8d8285	146	25	.	.	.
cord-016808-gy8d8285	147	1	Towards	towards	IN
cord-016808-gy8d8285	147	2	the	the	DT
cord-016808-gy8d8285	147	3	system	system	NN
cord-016808-gy8d8285	147	4	of	of	IN
cord-016808-gy8d8285	147	5	viruses	virus	NNS
cord-016808-gy8d8285	147	6	Expression	expression	NN
cord-016808-gy8d8285	147	7	of	of	IN
cord-016808-gy8d8285	147	8	animal	animal	NN
cord-016808-gy8d8285	147	9	virus	virus	NN
cord-016808-gy8d8285	147	10	genomes	genome	NNS
cord-016808-gy8d8285	148	1	Do	do	VBP
cord-016808-gy8d8285	148	2	viruses	virus	NNS
cord-016808-gy8d8285	148	3	form	form	VB
cord-016808-gy8d8285	148	4	lineages	lineage	NNS
cord-016808-gy8d8285	148	5	across	across	IN
cord-016808-gy8d8285	148	6	different	different	JJ
cord-016808-gy8d8285	148	7	domains	domain	NNS
cord-016808-gy8d8285	148	8	of	of	IN
cord-016808-gy8d8285	148	9	life	life	NN
cord-016808-gy8d8285	148	10	?	?	.
cord-016808-gy8d8285	149	1	Here	here	RB
cord-016808-gy8d8285	149	2	a	a	DT
cord-016808-gy8d8285	149	3	virus	virus	NN
cord-016808-gy8d8285	149	4	,	,	,
cord-016808-gy8d8285	149	5	there	there	EX
cord-016808-gy8d8285	149	6	a	a	DT
cord-016808-gy8d8285	149	7	virus	virus	NN
cord-016808-gy8d8285	149	8	,	,	,
cord-016808-gy8d8285	149	9	everywhere	everywhere	RB
cord-016808-gy8d8285	149	10	the	the	DT
cord-016808-gy8d8285	149	11	same	same	JJ
cord-016808-gy8d8285	149	12	virus	virus	NN
cord-016808-gy8d8285	149	13	?	?	.
cord-016808-gy8d8285	150	1	Three	three	CD
cord-016808-gy8d8285	150	2	RNA	RNA	NNP
cord-016808-gy8d8285	150	3	cells	cell	NNS
cord-016808-gy8d8285	150	4	for	for	IN
cord-016808-gy8d8285	150	5	ribosomal	ribosomal	JJ
cord-016808-gy8d8285	150	6	lineages	lineage	NNS
cord-016808-gy8d8285	150	7	and	and	CC
cord-016808-gy8d8285	150	8	three	three	CD
cord-016808-gy8d8285	150	9	DNA	dna	NN
cord-016808-gy8d8285	150	10	viruses	virus	NNS
cord-016808-gy8d8285	150	11	to	to	TO
cord-016808-gy8d8285	150	12	replicate	replicate	VB
cord-016808-gy8d8285	150	13	their	-PRON-	PRP$
cord-016808-gy8d8285	150	14	genomes	genome	NNS
cord-016808-gy8d8285	150	15	:	:	:
cord-016808-gy8d8285	150	16	A	a	DT
cord-016808-gy8d8285	150	17	hypothesis	hypothesis	NN
cord-016808-gy8d8285	150	18	for	for	IN
cord-016808-gy8d8285	150	19	the	the	DT
cord-016808-gy8d8285	150	20	origin	origin	NN
cord-016808-gy8d8285	150	21	of	of	IN
cord-016808-gy8d8285	150	22	cellular	cellular	JJ
cord-016808-gy8d8285	150	23	domain	domain	NN
cord-016808-gy8d8285	150	24	Origin	Origin	NNP
cord-016808-gy8d8285	150	25	of	of	IN
cord-016808-gy8d8285	150	26	HIV-1	HIV-1	NNP
cord-016808-gy8d8285	150	27	in	in	IN
cord-016808-gy8d8285	150	28	the	the	DT
cord-016808-gy8d8285	150	29	chimpanzee	chimpanzee	NN
cord-016808-gy8d8285	150	30	Pan	Pan	NNP
cord-016808-gy8d8285	150	31	troglodytes	troglodyte	NNS
cord-016808-gy8d8285	150	32	troglodytes	troglodyte	NNS
cord-016808-gy8d8285	150	33	Functional	functional	JJ
cord-016808-gy8d8285	150	34	and	and	CC
cord-016808-gy8d8285	150	35	genetic	genetic	JJ
cord-016808-gy8d8285	150	36	plasticities	plasticity	NNS
cord-016808-gy8d8285	150	37	of	of	IN
cord-016808-gy8d8285	150	38	the	the	DT
cord-016808-gy8d8285	150	39	poliovirus	poliovirus	NN
cord-016808-gy8d8285	150	40	genome	genome	NN
cord-016808-gy8d8285	150	41	:	:	:
cord-016808-gy8d8285	150	42	Quasi	quasi	JJ
cord-016808-gy8d8285	150	43	-	-	JJ
cord-016808-gy8d8285	150	44	infectious	infectious	JJ
cord-016808-gy8d8285	150	45	RNAs	rna	NNS
cord-016808-gy8d8285	150	46	modified	modify	VBN
cord-016808-gy8d8285	150	47	in	in	IN
cord-016808-gy8d8285	150	48	the	the	DT
cord-016808-gy8d8285	150	49	5	5	CD
cord-016808-gy8d8285	150	50	-untranslated	-untranslated	JJ
cord-016808-gy8d8285	150	51	region	region	NN
cord-016808-gy8d8285	150	52	yield	yield	VBP
cord-016808-gy8d8285	150	53	a	a	DT
cord-016808-gy8d8285	150	54	variety	variety	NN
cord-016808-gy8d8285	150	55	of	of	IN
cord-016808-gy8d8285	150	56	pseudorevertants	pseudorevertant	NNS
cord-016808-gy8d8285	150	57	Nonreplicative	Nonreplicative	NNP
cord-016808-gy8d8285	150	58	RNA	RNA	NNP
cord-016808-gy8d8285	150	59	recombination	recombination	NN
cord-016808-gy8d8285	150	60	in	in	IN
cord-016808-gy8d8285	150	61	poliovirus	poliovirus	NN
cord-016808-gy8d8285	150	62	Nonreplicative	Nonreplicative	NNP
cord-016808-gy8d8285	150	63	homologous	homologous	JJ
cord-016808-gy8d8285	150	64	RNA	RNA	NNP
cord-016808-gy8d8285	150	65	recombination	recombination	NN
cord-016808-gy8d8285	150	66	:	:	:
cord-016808-gy8d8285	150	67	Promiscuous	promiscuous	JJ
cord-016808-gy8d8285	150	68	joining	joining	NN
cord-016808-gy8d8285	150	69	of	of	IN
cord-016808-gy8d8285	150	70	RNA	RNA	NNP
cord-016808-gy8d8285	150	71	pieces	piece	NNS
cord-016808-gy8d8285	150	72	?	?	.
cord-016808-gy8d8285	151	1	Origins	origin	NNS
cord-016808-gy8d8285	151	2	of	of	IN
cord-016808-gy8d8285	151	3	HIV	HIV	NNP
cord-016808-gy8d8285	151	4	and	and	CC
cord-016808-gy8d8285	151	5	the	the	DT
cord-016808-gy8d8285	151	6	evolution	evolution	NN
cord-016808-gy8d8285	151	7	of	of	IN
cord-016808-gy8d8285	151	8	resistance	resistance	NN
cord-016808-gy8d8285	151	9	to	to	IN
cord-016808-gy8d8285	151	10	AIDS	AIDS	NNP
cord-016808-gy8d8285	152	1	On	on	IN
cord-016808-gy8d8285	152	2	the	the	DT
cord-016808-gy8d8285	152	3	origin	origin	NN
cord-016808-gy8d8285	152	4	of	of	IN
cord-016808-gy8d8285	152	5	genomes	genome	NNS
cord-016808-gy8d8285	152	6	and	and	CC
cord-016808-gy8d8285	152	7	cells	cell	NNS
cord-016808-gy8d8285	152	8	within	within	IN
cord-016808-gy8d8285	152	9	inorganic	inorganic	JJ
cord-016808-gy8d8285	152	10	compartments	compartment	NNS
cord-016808-gy8d8285	153	1	The	the	DT
cord-016808-gy8d8285	153	2	ancient	ancient	JJ
cord-016808-gy8d8285	153	3	virus	virus	NN
cord-016808-gy8d8285	153	4	world	world	NN
cord-016808-gy8d8285	153	5	and	and	CC
cord-016808-gy8d8285	153	6	evolution	evolution	NN
cord-016808-gy8d8285	153	7	of	of	IN
cord-016808-gy8d8285	153	8	cells	cell	NNS
cord-016808-gy8d8285	153	9	Severe	severe	JJ
cord-016808-gy8d8285	153	10	acute	acute	JJ
cord-016808-gy8d8285	153	11	respiratory	respiratory	JJ
cord-016808-gy8d8285	153	12	syndrome	syndrome	NN
cord-016808-gy8d8285	153	13	coronavirus	coronavirus	NN
cord-016808-gy8d8285	153	14	-	-	HYPH
cord-016808-gy8d8285	153	15	like	like	JJ
cord-016808-gy8d8285	153	16	virus	virus	NN
cord-016808-gy8d8285	153	17	in	in	IN
cord-016808-gy8d8285	153	18	Chinese	chinese	JJ
cord-016808-gy8d8285	153	19	horseshoe	horseshoe	NN
cord-016808-gy8d8285	153	20	bats	bat	NNS
cord-016808-gy8d8285	153	21	Bats	bat	NNS
cord-016808-gy8d8285	153	22	are	be	VBP
cord-016808-gy8d8285	153	23	natural	natural	JJ
cord-016808-gy8d8285	153	24	reservoirs	reservoir	NNS
cord-016808-gy8d8285	153	25	of	of	IN
cord-016808-gy8d8285	153	26	SARS	SARS	NNP
cord-016808-gy8d8285	153	27	-	-	HYPH
cord-016808-gy8d8285	153	28	like	like	JJ
cord-016808-gy8d8285	153	29	coronaviruses	coronaviruse	NNS
cord-016808-gy8d8285	154	1	A	a	DT
cord-016808-gy8d8285	154	2	single	single	JJ
cord-016808-gy8d8285	154	3	mutation	mutation	NN
cord-016808-gy8d8285	154	4	in	in	IN
cord-016808-gy8d8285	154	5	poliovirus	poliovirus	NN
cord-016808-gy8d8285	154	6	RNA	rna	NN
cord-016808-gy8d8285	154	7	-	-	HYPH
cord-016808-gy8d8285	154	8	dependent	dependent	JJ
cord-016808-gy8d8285	154	9	RNA	RNA	NNP
cord-016808-gy8d8285	154	10	polymerase	polymerase	NN
cord-016808-gy8d8285	154	11	confers	confer	VBZ
cord-016808-gy8d8285	154	12	resistance	resistance	NN
cord-016808-gy8d8285	154	13	to	to	IN
cord-016808-gy8d8285	154	14	mutagenic	mutagenic	JJ
cord-016808-gy8d8285	154	15	nucleotide	nucleotide	JJ
cord-016808-gy8d8285	154	16	analogs	analog	NNS
cord-016808-gy8d8285	154	17	via	via	IN
cord-016808-gy8d8285	155	1	increased	increase	VBN
cord-016808-gy8d8285	155	2	fidelity	fidelity	NN
cord-016808-gy8d8285	155	3	Increased	increase	VBN
cord-016808-gy8d8285	155	4	fidelity	fidelity	NN
cord-016808-gy8d8285	155	5	reduces	reduce	VBZ
cord-016808-gy8d8285	155	6	poliovirus	poliovirus	NN
cord-016808-gy8d8285	155	7	fitness	fitness	NN
cord-016808-gy8d8285	155	8	and	and	CC
cord-016808-gy8d8285	155	9	virulence	virulence	NN
cord-016808-gy8d8285	155	10	under	under	IN
cord-016808-gy8d8285	155	11	selective	selective	JJ
cord-016808-gy8d8285	155	12	pressure	pressure	NN
cord-016808-gy8d8285	155	13	in	in	IN
cord-016808-gy8d8285	155	14	mice	mouse	NNS
cord-016808-gy8d8285	155	15	Prokaryotic	Prokaryotic	NNP
cord-016808-gy8d8285	155	16	-	-	HYPH
cord-016808-gy8d8285	155	17	like	like	JJ
cord-016808-gy8d8285	155	18	cis	cis	NNP
cord-016808-gy8d8285	155	19	element	element	NN
cord-016808-gy8d8285	155	20	in	in	IN
cord-016808-gy8d8285	155	21	the	the	DT
cord-016808-gy8d8285	155	22	cap	cap	NN
cord-016808-gy8d8285	155	23	-	-	HYPH
cord-016808-gy8d8285	155	24	independent	independent	JJ
cord-016808-gy8d8285	155	25	internal	internal	JJ
cord-016808-gy8d8285	155	26	initiation	initiation	NN
cord-016808-gy8d8285	155	27	of	of	IN
cord-016808-gy8d8285	155	28	translation	translation	NN
cord-016808-gy8d8285	155	29	on	on	IN
cord-016808-gy8d8285	155	30	picornavirus	picornavirus	NNP
cord-016808-gy8d8285	155	31	RNA	RNA	NNP
cord-016808-gy8d8285	155	32	Cell	cell	NN
cord-016808-gy8d8285	155	33	-	-	HYPH
cord-016808-gy8d8285	155	34	specific	specific	JJ
cord-016808-gy8d8285	155	35	proteins	protein	NNS
cord-016808-gy8d8285	155	36	regulate	regulate	VBP
cord-016808-gy8d8285	155	37	viral	viral	JJ
cord-016808-gy8d8285	155	38	RNA	RNA	NNP
cord-016808-gy8d8285	155	39	translation	translation	NN
cord-016808-gy8d8285	155	40	and	and	CC
cord-016808-gy8d8285	155	41	virus	virus	NN
cord-016808-gy8d8285	155	42	-	-	HYPH
cord-016808-gy8d8285	155	43	induced	induce	VBN
cord-016808-gy8d8285	155	44	disease	disease	NN
cord-016808-gy8d8285	155	45	Viruses	virus	NNS
cord-016808-gy8d8285	155	46	in	in	IN
cord-016808-gy8d8285	155	47	the	the	DT
cord-016808-gy8d8285	155	48	sea	sea	NN
cord-016808-gy8d8285	155	49	Characterization	characterization	NN
cord-016808-gy8d8285	155	50	of	of	IN
cord-016808-gy8d8285	155	51	the	the	DT
cord-016808-gy8d8285	155	52	reconstructed	reconstruct	VBN
cord-016808-gy8d8285	155	53	1918	1918	CD
cord-016808-gy8d8285	155	54	Spanish	spanish	JJ
cord-016808-gy8d8285	155	55	influenza	influenza	NN
cord-016808-gy8d8285	155	56	pandemic	pandemic	NN
cord-016808-gy8d8285	155	57	virus	virus	NN
cord-016808-gy8d8285	155	58	.	.	.
cord-016808-gy8d8285	156	1	Science	science	NN
cord-016808-gy8d8285	156	2	Quasispecies	Quasispecies	NNP
cord-016808-gy8d8285	156	3	diversity	diversity	NN
cord-016808-gy8d8285	156	4	determines	determine	VBZ
cord-016808-gy8d8285	156	5	pathogenesis	pathogenesis	NN
cord-016808-gy8d8285	156	6	through	through	IN
cord-016808-gy8d8285	156	7	cooperative	cooperative	JJ
cord-016808-gy8d8285	156	8	interactions	interaction	NNS
cord-016808-gy8d8285	156	9	in	in	IN
cord-016808-gy8d8285	156	10	a	a	DT
cord-016808-gy8d8285	156	11	viral	viral	JJ
cord-016808-gy8d8285	156	12	population	population	NN