id sid tid token lemma pos cord-009571-mygj2nd4 1 1 key key JJ cord-009571-mygj2nd4 1 2 : : : cord-009571-mygj2nd4 1 3 cord-009571-mygj2nd4 cord-009571-mygj2nd4 NNS cord-009571-mygj2nd4 1 4 authors author NNS cord-009571-mygj2nd4 1 5 : : : cord-009571-mygj2nd4 2 1 nan nan NNP cord-009571-mygj2nd4 2 2 title title NN cord-009571-mygj2nd4 2 3 : : : cord-009571-mygj2nd4 2 4 Proceedings proceeding NNS cord-009571-mygj2nd4 2 5 of of IN cord-009571-mygj2nd4 2 6 the the DT cord-009571-mygj2nd4 2 7 42nd 42nd JJ cord-009571-mygj2nd4 2 8 annual annual JJ cord-009571-mygj2nd4 2 9 meeting meeting NN cord-009571-mygj2nd4 2 10 of of IN cord-009571-mygj2nd4 2 11 the the DT cord-009571-mygj2nd4 2 12 american american NNP cord-009571-mygj2nd4 2 13 rheumatism rheumatism NNP cord-009571-mygj2nd4 2 14 association association NNP cord-009571-mygj2nd4 2 15 a a DT cord-009571-mygj2nd4 2 16 section section NN cord-009571-mygj2nd4 2 17 of of IN cord-009571-mygj2nd4 2 18 the the DT cord-009571-mygj2nd4 2 19 arthritis arthritis NNP cord-009571-mygj2nd4 2 20 foundation foundation NNP cord-009571-mygj2nd4 2 21 june june NNP cord-009571-mygj2nd4 2 22 1 1 CD cord-009571-mygj2nd4 2 23 & & CC cord-009571-mygj2nd4 2 24 2 2 CD cord-009571-mygj2nd4 2 25 , , , cord-009571-mygj2nd4 2 26 1978 1978 CD cord-009571-mygj2nd4 2 27 new new NNP cord-009571-mygj2nd4 2 28 york york NNP cord-009571-mygj2nd4 2 29 city city NNP cord-009571-mygj2nd4 2 30 abstracts abstract NNS cord-009571-mygj2nd4 2 31 of of IN cord-009571-mygj2nd4 2 32 papers paper NNS cord-009571-mygj2nd4 2 33 presented present VBN cord-009571-mygj2nd4 2 34 date date NN cord-009571-mygj2nd4 3 1 : : : cord-009571-mygj2nd4 3 2 2005 2005 CD cord-009571-mygj2nd4 3 3 - - SYM cord-009571-mygj2nd4 3 4 11 11 CD cord-009571-mygj2nd4 3 5 - - SYM cord-009571-mygj2nd4 3 6 23 23 CD cord-009571-mygj2nd4 3 7 journal journal NN cord-009571-mygj2nd4 3 8 : : : cord-009571-mygj2nd4 4 1 Arthritis arthritis NN cord-009571-mygj2nd4 4 2 Rheum Rheum NNP cord-009571-mygj2nd4 4 3 DOI DOI NNP cord-009571-mygj2nd4 4 4 : : : cord-009571-mygj2nd4 4 5 10.1002/ 10.1002/ CD cord-009571-mygj2nd4 5 1 art.1780210508 art.1780210508 RB cord-009571-mygj2nd4 6 1 sha sha NNP cord-009571-mygj2nd4 6 2 : : : cord-009571-mygj2nd4 6 3 c715e3402491c24009f25d7a19176f2d62d36a37 c715e3402491c24009f25d7a19176f2d62d36a37 NNP cord-009571-mygj2nd4 6 4 doc_id doc_id NNP cord-009571-mygj2nd4 6 5 : : : cord-009571-mygj2nd4 6 6 9571 9571 CD cord-009571-mygj2nd4 6 7 cord_uid cord_uid NNS cord-009571-mygj2nd4 6 8 : : : cord-009571-mygj2nd4 7 1 mygj2nd4 mygj2nd4 XX cord-009571-mygj2nd4 8 1 nan nan NNP cord-009571-mygj2nd4 8 2 Azathioprine Azathioprine NNP cord-009571-mygj2nd4 8 3 has have VBZ cord-009571-mygj2nd4 8 4 been be VBN cord-009571-mygj2nd4 8 5 shown show VBN cord-009571-mygj2nd4 8 6 t t NN cord-009571-mygj2nd4 8 7 o o UH cord-009571-mygj2nd4 8 8 be be VB cord-009571-mygj2nd4 8 9 an an DT cord-009571-mygj2nd4 8 10 effective effective JJ cord-009571-mygj2nd4 8 11 agent agent NN cord-009571-mygj2nd4 8 12 in in IN cord-009571-mygj2nd4 8 13 the the DT cord-009571-mygj2nd4 8 14 treatment treatment NN cord-009571-mygj2nd4 8 15 of of IN cord-009571-mygj2nd4 8 16 active active JJ cord-009571-mygj2nd4 8 17 rheumatoid rheumatoid NN cord-009571-mygj2nd4 8 18 arthritis arthritis NN cord-009571-mygj2nd4 8 19 ( ( -LRB- cord-009571-mygj2nd4 8 20 RA RA NNP cord-009571-mygj2nd4 8 21 ) ) -RRB- cord-009571-mygj2nd4 8 22 ; ; : cord-009571-mygj2nd4 8 23 however however RB cord-009571-mygj2nd4 8 24 , , , cord-009571-mygj2nd4 8 25 potential potential JJ cord-009571-mygj2nd4 8 26 long long JJ cord-009571-mygj2nd4 8 27 - - HYPH cord-009571-mygj2nd4 8 28 term term NN cord-009571-mygj2nd4 8 29 neoplastic neoplastic JJ cord-009571-mygj2nd4 8 30 effects effect NNS cord-009571-mygj2nd4 8 31 remain remain VBP cord-009571-mygj2nd4 8 32 a a DT cord-009571-mygj2nd4 8 33 serious serious JJ cord-009571-mygj2nd4 8 34 concern concern NN cord-009571-mygj2nd4 8 35 . . . cord-009571-mygj2nd4 9 1 To to TO cord-009571-mygj2nd4 9 2 clarify clarify VB cord-009571-mygj2nd4 9 3 this this DT cord-009571-mygj2nd4 9 4 relationship relationship NN cord-009571-mygj2nd4 9 5 , , , cord-009571-mygj2nd4 9 6 36 36 CD cord-009571-mygj2nd4 9 7 patients patient NNS cord-009571-mygj2nd4 9 8 with with IN cord-009571-mygj2nd4 9 9 classic classic JJ cord-009571-mygj2nd4 9 10 or or CC cord-009571-mygj2nd4 9 11 definite definite JJ cord-009571-mygj2nd4 9 12 RA ra NN cord-009571-mygj2nd4 9 13 being be VBG cord-009571-mygj2nd4 9 14 treated treat VBN cord-009571-mygj2nd4 9 15 with with IN cord-009571-mygj2nd4 9 16 azathioprine azathioprine NN cord-009571-mygj2nd4 9 17 ( ( -LRB- cord-009571-mygj2nd4 9 18 Group group NN cord-009571-mygj2nd4 9 19 1 1 CD cord-009571-mygj2nd4 9 20 ) ) -RRB- cord-009571-mygj2nd4 9 21 were be VBD cord-009571-mygj2nd4 9 22 chosen choose VBN cord-009571-mygj2nd4 9 23 at at IN cord-009571-mygj2nd4 9 24 random random JJ cord-009571-mygj2nd4 9 25 and and CC cord-009571-mygj2nd4 9 26 studied study VBN cord-009571-mygj2nd4 9 27 by by IN cord-009571-mygj2nd4 9 28 means mean NNS cord-009571-mygj2nd4 9 29 of of IN cord-009571-mygj2nd4 9 30 clinical clinical JJ cord-009571-mygj2nd4 9 31 , , , cord-009571-mygj2nd4 9 32 laboratory laboratory NN cord-009571-mygj2nd4 9 33 , , , cord-009571-mygj2nd4 9 34 and and CC cord-009571-mygj2nd4 9 35 radiologic radiologic JJ cord-009571-mygj2nd4 9 36 measures measure NNS cord-009571-mygj2nd4 9 37 to to TO cord-009571-mygj2nd4 9 38 detect detect VB cord-009571-mygj2nd4 9 39 potential potential JJ cord-009571-mygj2nd4 9 40 early early JJ cord-009571-mygj2nd4 9 41 markers marker NNS cord-009571-mygj2nd4 9 42 of of IN cord-009571-mygj2nd4 9 43 neoplastic neoplastic JJ cord-009571-mygj2nd4 9 44 disease disease NN cord-009571-mygj2nd4 9 45 . . . cord-009571-mygj2nd4 10 1 Nineteen nineteen CD cord-009571-mygj2nd4 10 2 age age NN cord-009571-mygj2nd4 10 3 matched match VBD cord-009571-mygj2nd4 10 4 patients patient NNS cord-009571-mygj2nd4 10 5 with with IN cord-009571-mygj2nd4 10 6 RA RA NNP cord-009571-mygj2nd4 10 7 were be VBD cord-009571-mygj2nd4 10 8 concurrently concurrently RB cord-009571-mygj2nd4 10 9 similarly similarly RB cord-009571-mygj2nd4 10 10 studied study VBN cord-009571-mygj2nd4 10 11 as as IN cord-009571-mygj2nd4 10 12 controls control NNS cord-009571-mygj2nd4 10 13 ( ( -LRB- cord-009571-mygj2nd4 10 14 Group Group NNP cord-009571-mygj2nd4 10 15 2 2 CD cord-009571-mygj2nd4 10 16 ) ) -RRB- cord-009571-mygj2nd4 10 17 . . . cord-009571-mygj2nd4 11 1 Group group NN cord-009571-mygj2nd4 11 2 1 1 CD cord-009571-mygj2nd4 11 3 had have VBD cord-009571-mygj2nd4 11 4 a a DT cord-009571-mygj2nd4 11 5 longer long JJR cord-009571-mygj2nd4 11 6 disease disease NN cord-009571-mygj2nd4 11 7 duration duration NN cord-009571-mygj2nd4 11 8 ( ( -LRB- cord-009571-mygj2nd4 11 9 15.3 15.3 CD cord-009571-mygj2nd4 11 10 versus versus IN cord-009571-mygj2nd4 11 11 9.4 9.4 CD cord-009571-mygj2nd4 11 12 years year NNS cord-009571-mygj2nd4 11 13 ) ) -RRB- cord-009571-mygj2nd4 11 14 . . . cord-009571-mygj2nd4 12 1 The the DT cord-009571-mygj2nd4 12 2 mean mean JJ cord-009571-mygj2nd4 12 3 duration duration NN cord-009571-mygj2nd4 12 4 of of IN cord-009571-mygj2nd4 12 5 treatment treatment NN cord-009571-mygj2nd4 12 6 with with IN cord-009571-mygj2nd4 12 7 azathioprine azathioprine NN cord-009571-mygj2nd4 12 8 was be VBD cord-009571-mygj2nd4 12 9 38.3 38.3 CD cord-009571-mygj2nd4 12 10 months month NNS cord-009571-mygj2nd4 12 11 , , , cord-009571-mygj2nd4 12 12 with with IN cord-009571-mygj2nd4 12 13 a a DT cord-009571-mygj2nd4 12 14 mean mean JJ cord-009571-mygj2nd4 12 15 dose dose NN cord-009571-mygj2nd4 12 16 of of IN cord-009571-mygj2nd4 12 17 7 7 CD cord-009571-mygj2nd4 12 18 1.2 1.2 CD cord-009571-mygj2nd4 12 19 mg mg NNP cord-009571-mygj2nd4 12 20 / / SYM cord-009571-mygj2nd4 12 21 day day NN cord-009571-mygj2nd4 12 22 . . . cord-009571-mygj2nd4 13 1 Histories history NNS cord-009571-mygj2nd4 13 2 of of IN cord-009571-mygj2nd4 13 3 cigarette cigarette NN cord-009571-mygj2nd4 13 4 smoking smoking NN cord-009571-mygj2nd4 13 5 , , , cord-009571-mygj2nd4 13 6 hormone hormone NN cord-009571-mygj2nd4 13 7 treatment treatment NN cord-009571-mygj2nd4 13 8 , , , cord-009571-mygj2nd4 13 9 and and CC cord-009571-mygj2nd4 13 10 fertility fertility NN cord-009571-mygj2nd4 13 11 were be VBD cord-009571-mygj2nd4 13 12 comparable comparable JJ cord-009571-mygj2nd4 13 13 . . . cord-009571-mygj2nd4 14 1 Chest chest NN cord-009571-mygj2nd4 14 2 x x NNS cord-009571-mygj2nd4 14 3 - - NNS cord-009571-mygj2nd4 14 4 rays ray NNS cord-009571-mygj2nd4 14 5 revealed reveal VBD cord-009571-mygj2nd4 14 6 comparable comparable JJ cord-009571-mygj2nd4 14 7 numbers number NNS cord-009571-mygj2nd4 14 8 of of IN cord-009571-mygj2nd4 14 9 inflammatory inflammatory JJ cord-009571-mygj2nd4 14 10 and and CC cord-009571-mygj2nd4 14 11 fibrotic fibrotic JJ cord-009571-mygj2nd4 14 12 abnormalities abnormality NNS cord-009571-mygj2nd4 14 13 . . . cord-009571-mygj2nd4 15 1 There there EX cord-009571-mygj2nd4 15 2 was be VBD cord-009571-mygj2nd4 15 3 an an DT cord-009571-mygj2nd4 15 4 increased increase VBN cord-009571-mygj2nd4 15 5 frequency frequency NN cord-009571-mygj2nd4 15 6 of of IN cord-009571-mygj2nd4 15 7 tumors tumor NNS cord-009571-mygj2nd4 15 8 in in IN cord-009571-mygj2nd4 15 9 first first JJ cord-009571-mygj2nd4 15 10 degree degree NN cord-009571-mygj2nd4 15 11 relatives relative NNS cord-009571-mygj2nd4 15 12 in in IN cord-009571-mygj2nd4 15 13 Group Group NNP cord-009571-mygj2nd4 15 14 I I NNP cord-009571-mygj2nd4 15 15 ( ( -LRB- cord-009571-mygj2nd4 15 16 15 15 CD cord-009571-mygj2nd4 15 17 versus versus IN cord-009571-mygj2nd4 15 18 2 2 CD cord-009571-mygj2nd4 15 19 ) ) -RRB- cord-009571-mygj2nd4 15 20 . . . cord-009571-mygj2nd4 16 1 Hematologic Hematologic NNP cord-009571-mygj2nd4 16 2 studies study NNS cord-009571-mygj2nd4 16 3 revealed reveal VBD cord-009571-mygj2nd4 16 4 a a DT cord-009571-mygj2nd4 16 5 trend trend NN cord-009571-mygj2nd4 16 6 to to IN cord-009571-mygj2nd4 16 7 lower low JJR cord-009571-mygj2nd4 16 8 cell cell NN cord-009571-mygj2nd4 16 9 counts count NNS cord-009571-mygj2nd4 16 10 in in IN cord-009571-mygj2nd4 16 11 Group Group NNP cord-009571-mygj2nd4 16 12 1 1 CD cord-009571-mygj2nd4 16 13 with with IN cord-009571-mygj2nd4 16 14 a a DT cord-009571-mygj2nd4 16 15 striking striking JJ cord-009571-mygj2nd4 16 16 increase increase NN cord-009571-mygj2nd4 16 17 of of IN cord-009571-mygj2nd4 16 18 marrow marrow NN cord-009571-mygj2nd4 16 19 megaloblastosis megaloblastosis NN cord-009571-mygj2nd4 16 20 in in IN cord-009571-mygj2nd4 16 21 this this DT cord-009571-mygj2nd4 16 22 group group NN cord-009571-mygj2nd4 16 23 ( ( -LRB- cord-009571-mygj2nd4 16 24 28 28 CD cord-009571-mygj2nd4 16 25 versus versus IN cord-009571-mygj2nd4 16 26 I I NNP cord-009571-mygj2nd4 16 27 ) ) -RRB- cord-009571-mygj2nd4 16 28 . . . cord-009571-mygj2nd4 17 1 There there EX cord-009571-mygj2nd4 17 2 were be VBD cord-009571-mygj2nd4 17 3 no no DT cord-009571-mygj2nd4 17 4 differences difference NNS cord-009571-mygj2nd4 17 5 in in IN cord-009571-mygj2nd4 17 6 iron iron NN cord-009571-mygj2nd4 17 7 saturation saturation NN cord-009571-mygj2nd4 17 8 or or CC cord-009571-mygj2nd4 17 9 B12 b12 JJ cord-009571-mygj2nd4 17 10 levels level NNS cord-009571-mygj2nd4 17 11 . . . cord-009571-mygj2nd4 18 1 Serum serum NN cord-009571-mygj2nd4 18 2 folate folate NN cord-009571-mygj2nd4 18 3 was be VBD cord-009571-mygj2nd4 18 4 decreased decrease VBN cord-009571-mygj2nd4 18 5 in in IN cord-009571-mygj2nd4 18 6 Group Group NNP cord-009571-mygj2nd4 18 7 I i CD cord-009571-mygj2nd4 18 8 ( ( -LRB- cord-009571-mygj2nd4 18 9 14 14 CD cord-009571-mygj2nd4 18 10 versus versus IN cord-009571-mygj2nd4 18 11 2 2 CD cord-009571-mygj2nd4 18 12 ) ) -RRB- cord-009571-mygj2nd4 18 13 . . . cord-009571-mygj2nd4 19 1 There there EX cord-009571-mygj2nd4 19 2 were be VBD cord-009571-mygj2nd4 19 3 neither neither DT cord-009571-mygj2nd4 19 4 liver liver NN cord-009571-mygj2nd4 19 5 function function NN cord-009571-mygj2nd4 19 6 test test NN cord-009571-mygj2nd4 19 7 abnormalities abnormality NNS cord-009571-mygj2nd4 19 8 in in IN cord-009571-mygj2nd4 19 9 Group Group NNP cord-009571-mygj2nd4 19 10 1 1 CD cord-009571-mygj2nd4 19 11 , , , cord-009571-mygj2nd4 19 12 nor nor CC cord-009571-mygj2nd4 19 13 evidence evidence NN cord-009571-mygj2nd4 19 14 of of IN cord-009571-mygj2nd4 19 15 malignancy malignancy NN cord-009571-mygj2nd4 19 16 in in IN cord-009571-mygj2nd4 19 17 gastrointestinal gastrointestinal JJ cord-009571-mygj2nd4 19 18 x x NNS cord-009571-mygj2nd4 19 19 - - NNS cord-009571-mygj2nd4 19 20 rays ray NNS cord-009571-mygj2nd4 19 21 when when WRB cord-009571-mygj2nd4 19 22 clinically clinically RB cord-009571-mygj2nd4 19 23 indicated indicate VBN cord-009571-mygj2nd4 19 24 . . . cord-009571-mygj2nd4 20 1 No no DT cord-009571-mygj2nd4 20 2 neoplastic neoplastic JJ cord-009571-mygj2nd4 20 3 lesions lesion NNS cord-009571-mygj2nd4 20 4 were be VBD cord-009571-mygj2nd4 20 5 identified identify VBN cord-009571-mygj2nd4 20 6 on on IN cord-009571-mygj2nd4 20 7 mammography mammography NN cord-009571-mygj2nd4 20 8 in in IN cord-009571-mygj2nd4 20 9 either either DT cord-009571-mygj2nd4 20 10 group group NN cord-009571-mygj2nd4 20 11 . . . cord-009571-mygj2nd4 21 1 Four four CD cord-009571-mygj2nd4 21 2 patients patient NNS cord-009571-mygj2nd4 21 3 in in IN cord-009571-mygj2nd4 21 4 Group Group NNP cord-009571-mygj2nd4 21 5 1 1 CD cord-009571-mygj2nd4 21 6 and and CC cord-009571-mygj2nd4 21 7 none none NN cord-009571-mygj2nd4 21 8 in in IN cord-009571-mygj2nd4 21 9 Group Group NNP cord-009571-mygj2nd4 21 10 2 2 CD cord-009571-mygj2nd4 21 11 had have VBD cord-009571-mygj2nd4 21 12 atypical atypical JJ cord-009571-mygj2nd4 21 13 or or CC cord-009571-mygj2nd4 21 14 dyskaryotic dyskaryotic JJ cord-009571-mygj2nd4 21 15 cells cell NNS cord-009571-mygj2nd4 21 16 on on IN cord-009571-mygj2nd4 21 17 urine urine NN cord-009571-mygj2nd4 21 18 cytology cytology NN cord-009571-mygj2nd4 21 19 . . . cord-009571-mygj2nd4 22 1 One one CD cord-009571-mygj2nd4 22 2 patient patient NN cord-009571-mygj2nd4 22 3 in in IN cord-009571-mygj2nd4 22 4 Group Group NNP cord-009571-mygj2nd4 22 5 1 1 CD cord-009571-mygj2nd4 22 6 had have VBD cord-009571-mygj2nd4 22 7 an an DT cord-009571-mygj2nd4 22 8 abnormal abnormal JJ cord-009571-mygj2nd4 22 9 Pap pap NN cord-009571-mygj2nd4 22 10 smear smear NN cord-009571-mygj2nd4 22 11 and and CC cord-009571-mygj2nd4 22 12 was be VBD cord-009571-mygj2nd4 22 13 subsequently subsequently RB cord-009571-mygj2nd4 22 14 shown show VBN cord-009571-mygj2nd4 22 15 to to TO cord-009571-mygj2nd4 22 16 have have VB cord-009571-mygj2nd4 22 17 endometrial endometrial JJ cord-009571-mygj2nd4 22 18 carcinoma carcinoma NN cord-009571-mygj2nd4 22 19 , , . cord-009571-mygj2nd4 23 1 On on IN cord-009571-mygj2nd4 23 2 chromosomal chromosomal JJ cord-009571-mygj2nd4 23 3 analysis analysis NN cord-009571-mygj2nd4 23 4 , , , cord-009571-mygj2nd4 23 5 Group Group NNP cord-009571-mygj2nd4 23 6 I -PRON- PRP cord-009571-mygj2nd4 23 7 showed show VBD cord-009571-mygj2nd4 23 8 a a DT cord-009571-mygj2nd4 23 9 greater great JJR cord-009571-mygj2nd4 23 10 percent percent NN cord-009571-mygj2nd4 23 11 of of IN cord-009571-mygj2nd4 23 12 cells cell NNS cord-009571-mygj2nd4 23 13 with with IN cord-009571-mygj2nd4 23 14 aberrations aberration NNS cord-009571-mygj2nd4 23 15 , , , cord-009571-mygj2nd4 23 16 a a DT cord-009571-mygj2nd4 23 17 higher high JJR cord-009571-mygj2nd4 23 18 aberration aberration NN cord-009571-mygj2nd4 23 19 incidence incidence NN cord-009571-mygj2nd4 23 20 and and CC cord-009571-mygj2nd4 23 21 index index NN cord-009571-mygj2nd4 23 22 , , , cord-009571-mygj2nd4 23 23 and and CC cord-009571-mygj2nd4 23 24 more more JJR cord-009571-mygj2nd4 23 25 patients patient NNS cord-009571-mygj2nd4 23 26 with with IN cord-009571-mygj2nd4 23 27 hyperdiploidy hyperdiploidy NNP cord-009571-mygj2nd4 23 28 . . . cord-009571-mygj2nd4 24 1 Patients patient NNS cord-009571-mygj2nd4 24 2 in in IN cord-009571-mygj2nd4 24 3 Group Group NNP cord-009571-mygj2nd4 24 4 2 2 CD cord-009571-mygj2nd4 24 5 had have VBD cord-009571-mygj2nd4 24 6 a a DT cord-009571-mygj2nd4 24 7 history history NN cord-009571-mygj2nd4 24 8 of of IN cord-009571-mygj2nd4 24 9 3 3 CD cord-009571-mygj2nd4 24 10 benign benign JJ cord-009571-mygj2nd4 24 11 neoplasms neoplasm NNS cord-009571-mygj2nd4 24 12 . . . cord-009571-mygj2nd4 25 1 Patients patient NNS cord-009571-mygj2nd4 25 2 in in IN cord-009571-mygj2nd4 25 3 Group Group NNP cord-009571-mygj2nd4 26 1 I -PRON- PRP cord-009571-mygj2nd4 26 2 had have VBD cord-009571-mygj2nd4 26 3 a a DT cord-009571-mygj2nd4 26 4 history history NN cord-009571-mygj2nd4 26 5 of of IN cord-009571-mygj2nd4 26 6 I -PRON- PRP cord-009571-mygj2nd4 26 7 benign benign JJ cord-009571-mygj2nd4 26 8 neoplasm neoplasm NN cord-009571-mygj2nd4 26 9 prior prior RB cord-009571-mygj2nd4 26 10 to to IN cord-009571-mygj2nd4 26 11 the the DT cord-009571-mygj2nd4 26 12 initiation initiation NN cord-009571-mygj2nd4 26 13 of of IN cord-009571-mygj2nd4 26 14 azathioprine azathioprine NN cord-009571-mygj2nd4 26 15 ; ; : cord-009571-mygj2nd4 26 16 subsequently subsequently RB cord-009571-mygj2nd4 26 17 7 7 CD cord-009571-mygj2nd4 26 18 neoplasms neoplasm NNS cord-009571-mygj2nd4 26 19 were be VBD cord-009571-mygj2nd4 26 20 diagnosed diagnose VBN cord-009571-mygj2nd4 26 21 , , , cord-009571-mygj2nd4 26 22 4 4 CD cord-009571-mygj2nd4 26 23 benign benign JJ cord-009571-mygj2nd4 26 24 and and CC cord-009571-mygj2nd4 26 25 3 3 CD cord-009571-mygj2nd4 26 26 malignant malignant JJ cord-009571-mygj2nd4 26 27 ( ( -LRB- cord-009571-mygj2nd4 26 28 2 2 CD cord-009571-mygj2nd4 26 29 endometrial endometrial JJ cord-009571-mygj2nd4 26 30 carcinomas carcinoma NNS cord-009571-mygj2nd4 26 31 and and CC cord-009571-mygj2nd4 26 32 carcinoma carcinoma NN cord-009571-mygj2nd4 26 33 - - HYPH cord-009571-mygj2nd4 26 34 in in IN cord-009571-mygj2nd4 26 35 - - HYPH cord-009571-mygj2nd4 26 36 situ situ NN cord-009571-mygj2nd4 26 37 of of IN cord-009571-mygj2nd4 26 38 the the DT cord-009571-mygj2nd4 26 39 cervix cervix NN cord-009571-mygj2nd4 26 40 ) ) -RRB- cord-009571-mygj2nd4 26 41 . . . cord-009571-mygj2nd4 27 1 In in IN cord-009571-mygj2nd4 27 2 summary summary NN cord-009571-mygj2nd4 27 3 , , , cord-009571-mygj2nd4 27 4 Group Group NNP cord-009571-mygj2nd4 27 5 I -PRON- PRP cord-009571-mygj2nd4 27 6 had have VBD cord-009571-mygj2nd4 27 7 an an DT cord-009571-mygj2nd4 27 8 increased increase VBN cord-009571-mygj2nd4 27 9 number number NN cord-009571-mygj2nd4 27 10 of of IN cord-009571-mygj2nd4 27 11 cellular cellular JJ cord-009571-mygj2nd4 27 12 abnormalities abnormality NNS cord-009571-mygj2nd4 27 13 , , , cord-009571-mygj2nd4 27 14 with with IN cord-009571-mygj2nd4 27 15 cytologic cytologic JJ cord-009571-mygj2nd4 27 16 atypia atypia NNP cord-009571-mygj2nd4 27 17 , , , cord-009571-mygj2nd4 27 18 megaloblastic megaloblastic JJ cord-009571-mygj2nd4 27 19 bone bone NN cord-009571-mygj2nd4 27 20 marrows marrow NNS cord-009571-mygj2nd4 27 21 , , , cord-009571-mygj2nd4 27 22 and and CC cord-009571-mygj2nd4 27 23 increased increase VBN cord-009571-mygj2nd4 27 24 chromosomal chromosomal JJ cord-009571-mygj2nd4 27 25 aberrations aberration NNS cord-009571-mygj2nd4 27 26 . . . cord-009571-mygj2nd4 28 1 Clinically clinically RB cord-009571-mygj2nd4 28 2 this this DT cord-009571-mygj2nd4 28 3 group group NN cord-009571-mygj2nd4 28 4 had have VBD cord-009571-mygj2nd4 28 5 more more JJR cord-009571-mygj2nd4 28 6 tumors tumor NNS cord-009571-mygj2nd4 28 7 diagnosed diagnose VBN cord-009571-mygj2nd4 28 8 while while NN cord-009571-mygj2nd4 28 9 on on IN cord-009571-mygj2nd4 28 10 treatment treatment NN cord-009571-mygj2nd4 28 11 , , , cord-009571-mygj2nd4 28 12 particularly particularly RB cord-009571-mygj2nd4 28 13 in in IN cord-009571-mygj2nd4 28 14 females female NNS cord-009571-mygj2nd4 28 15 , , , cord-009571-mygj2nd4 28 16 and and CC cord-009571-mygj2nd4 28 17 arising arise VBG cord-009571-mygj2nd4 28 18 from from IN cord-009571-mygj2nd4 28 19 the the DT cord-009571-mygj2nd4 28 20 genitourinary genitourinary JJ cord-009571-mygj2nd4 28 21 tract tract NN cord-009571-mygj2nd4 28 22 . . . cord-009571-mygj2nd4 29 1 More More JJR cord-009571-mygj2nd4 29 2 long long JJ cord-009571-mygj2nd4 29 3 - - HYPH cord-009571-mygj2nd4 29 4 term term NN cord-009571-mygj2nd4 29 5 studies study NNS cord-009571-mygj2nd4 29 6 of of IN cord-009571-mygj2nd4 29 7 patients patient NNS cord-009571-mygj2nd4 29 8 on on IN cord-009571-mygj2nd4 29 9 cytotoxic cytotoxic JJ cord-009571-mygj2nd4 29 10 agents agent NNS cord-009571-mygj2nd4 29 11 are be VBP cord-009571-mygj2nd4 29 12 clearly clearly RB cord-009571-mygj2nd4 29 13 warranted warrant VBN cord-009571-mygj2nd4 29 14 . . . cord-009571-mygj2nd4 30 1 solid solid JJ cord-009571-mygj2nd4 30 2 phase phase NN cord-009571-mygj2nd4 31 1 Clq Clq NNP cord-009571-mygj2nd4 31 2 ( ( -LRB- cord-009571-mygj2nd4 31 3 SClq SClq NNP cord-009571-mygj2nd4 31 4 ) ) -RRB- cord-009571-mygj2nd4 31 5 radioimmunoassays radioimmunoassay NNS cord-009571-mygj2nd4 31 6 . . . cord-009571-mygj2nd4 32 1 C3 C3 NNP cord-009571-mygj2nd4 32 2 was be VBD cord-009571-mygj2nd4 32 3 determined determine VBN cord-009571-mygj2nd4 32 4 by by IN cord-009571-mygj2nd4 32 5 radial radial JJ cord-009571-mygj2nd4 32 6 immunodiffusion immunodiffusion NN cord-009571-mygj2nd4 32 7 and and CC cord-009571-mygj2nd4 32 8 antibodies antibody NNS cord-009571-mygj2nd4 32 9 to to IN cord-009571-mygj2nd4 32 10 DNA DNA NNP cord-009571-mygj2nd4 32 11 by by IN cord-009571-mygj2nd4 32 12 binding bind VBG cord-009571-mygj2nd4 32 13 of of IN cord-009571-mygj2nd4 32 14 radiolabeled radiolabele VBN cord-009571-mygj2nd4 32 15 DNA dna NN cord-009571-mygj2nd4 32 16 by by IN cord-009571-mygj2nd4 32 17 the the DT cord-009571-mygj2nd4 32 18 millipore millipore NNP cord-009571-mygj2nd4 32 19 filter filter NN cord-009571-mygj2nd4 32 20 technique technique NN cord-009571-mygj2nd4 32 21 . . . cord-009571-mygj2nd4 33 1 These these DT cord-009571-mygj2nd4 33 2 assays assay NNS cord-009571-mygj2nd4 33 3 were be VBD cord-009571-mygj2nd4 33 4 correlated correlate VBN cord-009571-mygj2nd4 33 5 with with IN cord-009571-mygj2nd4 33 6 each each DT cord-009571-mygj2nd4 33 7 other other JJ cord-009571-mygj2nd4 33 8 , , , cord-009571-mygj2nd4 33 9 general general JJ cord-009571-mygj2nd4 33 10 presence presence NN cord-009571-mygj2nd4 33 11 or or CC cord-009571-mygj2nd4 33 12 absence absence NN cord-009571-mygj2nd4 33 13 of of IN cord-009571-mygj2nd4 33 14 symptomatic symptomatic JJ cord-009571-mygj2nd4 33 15 disease disease NN cord-009571-mygj2nd4 33 16 , , , cord-009571-mygj2nd4 33 17 active active JJ cord-009571-mygj2nd4 33 18 renal renal JJ cord-009571-mygj2nd4 33 19 disease disease NN cord-009571-mygj2nd4 33 20 , , , cord-009571-mygj2nd4 33 21 and and CC cord-009571-mygj2nd4 33 22 active active JJ cord-009571-mygj2nd4 33 23 joint joint JJ cord-009571-mygj2nd4 33 24 disease disease NN cord-009571-mygj2nd4 33 25 . . . cord-009571-mygj2nd4 34 1 To to TO cord-009571-mygj2nd4 34 2 evaluate evaluate VB cord-009571-mygj2nd4 34 3 predictive predictive JJ cord-009571-mygj2nd4 34 4 capabilities capability NNS cord-009571-mygj2nd4 34 5 , , , cord-009571-mygj2nd4 34 6 a a DT cord-009571-mygj2nd4 34 7 change change NN cord-009571-mygj2nd4 34 8 in in IN cord-009571-mygj2nd4 34 9 CIC CIC NNP cord-009571-mygj2nd4 34 10 result result NN cord-009571-mygj2nd4 34 11 was be VBD cord-009571-mygj2nd4 34 12 correlated correlate VBN cord-009571-mygj2nd4 34 13 with with IN cord-009571-mygj2nd4 34 14 a a DT cord-009571-mygj2nd4 34 15 change change NN cord-009571-mygj2nd4 34 16 in in IN cord-009571-mygj2nd4 34 17 disease disease NN cord-009571-mygj2nd4 34 18 activity activity NN cord-009571-mygj2nd4 34 19 . . . cord-009571-mygj2nd4 35 1 Change change VB cord-009571-mygj2nd4 35 2 in in IN cord-009571-mygj2nd4 35 3 disease disease NN cord-009571-mygj2nd4 35 4 activity activity NN cord-009571-mygj2nd4 35 5 was be VBD cord-009571-mygj2nd4 35 6 defined define VBN cord-009571-mygj2nd4 35 7 as as IN cord-009571-mygj2nd4 35 8 an an DT cord-009571-mygj2nd4 35 9 SLE SLE NNP cord-009571-mygj2nd4 35 10 related relate VBN cord-009571-mygj2nd4 35 11 event event NN cord-009571-mygj2nd4 35 12 requiring require VBG cord-009571-mygj2nd4 35 13 hospitalization hospitalization NN cord-009571-mygj2nd4 35 14 , , , cord-009571-mygj2nd4 35 15 a a DT cord-009571-mygj2nd4 35 16 change change NN cord-009571-mygj2nd4 35 17 in in IN cord-009571-mygj2nd4 35 18 symptoms symptom NNS cord-009571-mygj2nd4 35 19 requiring require VBG cord-009571-mygj2nd4 35 20 an an DT cord-009571-mygj2nd4 35 21 increase increase NN cord-009571-mygj2nd4 35 22 in in IN cord-009571-mygj2nd4 35 23 or or CC cord-009571-mygj2nd4 35 24 addition addition NN cord-009571-mygj2nd4 35 25 of of IN cord-009571-mygj2nd4 35 26 steroids steroid NNS cord-009571-mygj2nd4 35 27 or or CC cord-009571-mygj2nd4 35 28 immunosuppressive immunosuppressive JJ cord-009571-mygj2nd4 35 29 agents agent NNS cord-009571-mygj2nd4 35 30 , , , cord-009571-mygj2nd4 35 31 or or CC cord-009571-mygj2nd4 35 32 a a DT cord-009571-mygj2nd4 35 33 marked mark VBN cord-009571-mygj2nd4 35 34 improvement improvement NN cord-009571-mygj2nd4 35 35 in in IN cord-009571-mygj2nd4 35 36 symptoms symptom NNS cord-009571-mygj2nd4 35 37 such such JJ cord-009571-mygj2nd4 35 38 that that IN cord-009571-mygj2nd4 35 39 drugs drug NNS cord-009571-mygj2nd4 35 40 were be VBD cord-009571-mygj2nd4 35 41 tapered taper VBN cord-009571-mygj2nd4 35 42 or or CC cord-009571-mygj2nd4 35 43 discontinued discontinue VBN cord-009571-mygj2nd4 35 44 . . . cord-009571-mygj2nd4 36 1 The the DT cord-009571-mygj2nd4 36 2 FClq FClq NNP cord-009571-mygj2nd4 36 3 results result NNS cord-009571-mygj2nd4 36 4 did do VBD cord-009571-mygj2nd4 36 5 not not RB cord-009571-mygj2nd4 36 6 correlate correlate VB cord-009571-mygj2nd4 36 7 with with IN cord-009571-mygj2nd4 36 8 any any DT cord-009571-mygj2nd4 36 9 parameters parameter NNS cord-009571-mygj2nd4 36 10 of of IN cord-009571-mygj2nd4 36 11 disease disease NN cord-009571-mygj2nd4 36 12 activity activity NN cord-009571-mygj2nd4 36 13 . . . cord-009571-mygj2nd4 37 1 A a DT cord-009571-mygj2nd4 37 2 fall fall NN cord-009571-mygj2nd4 37 3 in in IN cord-009571-mygj2nd4 37 4 C3 c3 NN cord-009571-mygj2nd4 37 5 or or CC cord-009571-mygj2nd4 37 6 an an DT cord-009571-mygj2nd4 37 7 increase increase NN cord-009571-mygj2nd4 37 8 in in IN cord-009571-mygj2nd4 37 9 antibodies antibody NNS cord-009571-mygj2nd4 37 10 to to IN cord-009571-mygj2nd4 37 11 DNA DNA NNP cord-009571-mygj2nd4 37 12 usually usually RB cord-009571-mygj2nd4 37 13 signaled signal VBD cord-009571-mygj2nd4 37 14 a a DT cord-009571-mygj2nd4 37 15 change change NN cord-009571-mygj2nd4 37 16 in in IN cord-009571-mygj2nd4 37 17 disease disease NN cord-009571-mygj2nd4 37 18 activity activity NN cord-009571-mygj2nd4 37 19 ; ; : cord-009571-mygj2nd4 37 20 however however RB cord-009571-mygj2nd4 37 21 , , , cord-009571-mygj2nd4 37 22 many many JJ cord-009571-mygj2nd4 37 23 patients patient NNS cord-009571-mygj2nd4 37 24 experienced experience VBD cord-009571-mygj2nd4 37 25 a a DT cord-009571-mygj2nd4 37 26 change change NN cord-009571-mygj2nd4 37 27 in in IN cord-009571-mygj2nd4 37 28 disease disease NN cord-009571-mygj2nd4 37 29 activity activity NN cord-009571-mygj2nd4 37 30 without without IN cord-009571-mygj2nd4 37 31 any any DT cord-009571-mygj2nd4 37 32 change change NN cord-009571-mygj2nd4 37 33 in in IN cord-009571-mygj2nd4 37 34 C3 c3 NN cord-009571-mygj2nd4 37 35 or or CC cord-009571-mygj2nd4 37 36 DNA dna NN cord-009571-mygj2nd4 37 37 binding binding NN cord-009571-mygj2nd4 37 38 . . . cord-009571-mygj2nd4 38 1 The the DT cord-009571-mygj2nd4 38 2 SClq SClq NNP cord-009571-mygj2nd4 38 3 assay assay NN cord-009571-mygj2nd4 38 4 correlated correlate VBN cord-009571-mygj2nd4 38 5 with with IN cord-009571-mygj2nd4 38 6 symptoms symptom NNS cord-009571-mygj2nd4 38 7 of of IN cord-009571-mygj2nd4 38 8 SLE SLE NNP cord-009571-mygj2nd4 38 9 in in IN cord-009571-mygj2nd4 38 10 general general JJ cord-009571-mygj2nd4 38 11 ( ( -LRB- cord-009571-mygj2nd4 38 12 P p NN cord-009571-mygj2nd4 38 13 < < XX cord-009571-mygj2nd4 38 14 0.001 0.001 CD cord-009571-mygj2nd4 38 15 ) ) -RRB- cord-009571-mygj2nd4 38 16 , , , cord-009571-mygj2nd4 38 17 with with IN cord-009571-mygj2nd4 38 18 active active JJ cord-009571-mygj2nd4 38 19 renal renal JJ cord-009571-mygj2nd4 38 20 disease disease NN cord-009571-mygj2nd4 38 21 ( ( -LRB- cord-009571-mygj2nd4 38 22 P p NN cord-009571-mygj2nd4 38 23 < < XX cord-009571-mygj2nd4 38 24 0.025 0.025 CD cord-009571-mygj2nd4 38 25 ) ) -RRB- cord-009571-mygj2nd4 38 26 , , , cord-009571-mygj2nd4 38 27 and and CC cord-009571-mygj2nd4 38 28 with with IN cord-009571-mygj2nd4 38 29 active active JJ cord-009571-mygj2nd4 38 30 arthritis arthritis NN cord-009571-mygj2nd4 38 31 ( ( -LRB- cord-009571-mygj2nd4 38 32 P p NN cord-009571-mygj2nd4 38 33 < < XX cord-009571-mygj2nd4 38 34 0.001 0.001 CD cord-009571-mygj2nd4 38 35 ) ) -RRB- cord-009571-mygj2nd4 38 36 . . . cord-009571-mygj2nd4 39 1 An an DT cord-009571-mygj2nd4 39 2 appropriate appropriate JJ cord-009571-mygj2nd4 39 3 change change NN cord-009571-mygj2nd4 39 4 in in IN cord-009571-mygj2nd4 39 5 SClq SClq NNP cord-009571-mygj2nd4 39 6 determination determination NN cord-009571-mygj2nd4 39 7 correlated correlate VBD cord-009571-mygj2nd4 39 8 best well RBS cord-009571-mygj2nd4 39 9 with with IN cord-009571-mygj2nd4 39 10 a a DT cord-009571-mygj2nd4 39 11 significant significant JJ cord-009571-mygj2nd4 39 12 change change NN cord-009571-mygj2nd4 39 13 in in IN cord-009571-mygj2nd4 39 14 disease disease NN cord-009571-mygj2nd4 39 15 activity activity NN cord-009571-mygj2nd4 39 16 ( ( -LRB- cord-009571-mygj2nd4 39 17 P p NN cord-009571-mygj2nd4 39 18 < < XX cord-009571-mygj2nd4 39 19 0.001 0.001 CD cord-009571-mygj2nd4 39 20 ) ) -RRB- cord-009571-mygj2nd4 39 21 . . . cord-009571-mygj2nd4 40 1 We -PRON- PRP cord-009571-mygj2nd4 40 2 conclude conclude VBP cord-009571-mygj2nd4 40 3 that that IN cord-009571-mygj2nd4 40 4 the the DT cord-009571-mygj2nd4 40 5 SClq SClq NNP cord-009571-mygj2nd4 40 6 method method NN cord-009571-mygj2nd4 40 7 of of IN cord-009571-mygj2nd4 40 8 determining determine VBG cord-009571-mygj2nd4 40 9 CIC CIC NNP cord-009571-mygj2nd4 40 10 correlates correlate VBZ cord-009571-mygj2nd4 40 11 best well RBS cord-009571-mygj2nd4 40 12 with with IN cord-009571-mygj2nd4 40 13 active active JJ cord-009571-mygj2nd4 40 14 clinical clinical JJ cord-009571-mygj2nd4 40 15 manifestations manifestation NNS cord-009571-mygj2nd4 40 16 of of IN cord-009571-mygj2nd4 40 17 SLE SLE NNP cord-009571-mygj2nd4 40 18 and and CC cord-009571-mygj2nd4 40 19 is be VBZ cord-009571-mygj2nd4 40 20 a a DT cord-009571-mygj2nd4 40 21 useful useful JJ cord-009571-mygj2nd4 40 22 predictor predictor NN cord-009571-mygj2nd4 40 23 of of IN cord-009571-mygj2nd4 40 24 disease disease NN cord-009571-mygj2nd4 40 25 activity activity NN cord-009571-mygj2nd4 40 26 . . . cord-009571-mygj2nd4 41 1 We -PRON- PRP cord-009571-mygj2nd4 41 2 have have VBP cord-009571-mygj2nd4 41 3 recently recently RB cord-009571-mygj2nd4 41 4 found find VBN cord-009571-mygj2nd4 41 5 that that IN cord-009571-mygj2nd4 41 6 certain certain JJ cord-009571-mygj2nd4 41 7 rheumatoid rheumatoid NN cord-009571-mygj2nd4 41 8 factors factor NNS cord-009571-mygj2nd4 41 9 ( ( -LRB- cord-009571-mygj2nd4 41 10 RFs RFs NNP cord-009571-mygj2nd4 41 11 ) ) -RRB- cord-009571-mygj2nd4 41 12 cross cross NN cord-009571-mygj2nd4 41 13 react react VB cord-009571-mygj2nd4 41 14 with with IN cord-009571-mygj2nd4 41 15 DNA dna NN cord-009571-mygj2nd4 41 16 - - HYPH cord-009571-mygj2nd4 41 17 protein protein NN cord-009571-mygj2nd4 41 18 ( ( -LRB- cord-009571-mygj2nd4 41 19 DNP DNP NNP cord-009571-mygj2nd4 41 20 ) ) -RRB- cord-009571-mygj2nd4 41 21 . . . cord-009571-mygj2nd4 42 1 This this DT cord-009571-mygj2nd4 42 2 type type NN cord-009571-mygj2nd4 42 3 of of IN cord-009571-mygj2nd4 42 4 cross cross NN cord-009571-mygj2nd4 42 5 reacting react VBG cord-009571-mygj2nd4 42 6 R R NNP cord-009571-mygj2nd4 42 7 F F NNP cord-009571-mygj2nd4 42 8 is be VBZ cord-009571-mygj2nd4 42 9 frequently frequently RB cord-009571-mygj2nd4 42 10 present present JJ cord-009571-mygj2nd4 42 11 in in IN cord-009571-mygj2nd4 42 12 seropositive seropositive JJ cord-009571-mygj2nd4 42 13 rheumatoid rheumatoid NN cord-009571-mygj2nd4 42 14 arthritis arthritis NN cord-009571-mygj2nd4 42 15 ( ( -LRB- cord-009571-mygj2nd4 42 16 RA RA NNP cord-009571-mygj2nd4 42 17 ) ) -RRB- cord-009571-mygj2nd4 42 18 , , , cord-009571-mygj2nd4 42 19 21 21 CD cord-009571-mygj2nd4 42 20 of of IN cord-009571-mygj2nd4 42 21 58 58 CD cord-009571-mygj2nd4 42 22 patients patient NNS cord-009571-mygj2nd4 42 23 , , , cord-009571-mygj2nd4 42 24 and and CC cord-009571-mygj2nd4 42 25 also also RB cord-009571-mygj2nd4 42 26 in in IN cord-009571-mygj2nd4 42 27 order order NN cord-009571-mygj2nd4 42 28 R R NNP cord-009571-mygj2nd4 42 29 F F NNP cord-009571-mygj2nd4 42 30 positive positive JJ cord-009571-mygj2nd4 42 31 patients patient NNS cord-009571-mygj2nd4 42 32 : : : cord-009571-mygj2nd4 42 33 rheumatoid rheumatoid NNP cord-009571-mygj2nd4 42 34 overlap overlap NN cord-009571-mygj2nd4 42 35 syndrome syndrome NN cord-009571-mygj2nd4 42 36 4/10 4/10 CD cord-009571-mygj2nd4 42 37 , , , cord-009571-mygj2nd4 42 38 mixed mixed JJ cord-009571-mygj2nd4 42 39 connective connective JJ cord-009571-mygj2nd4 42 40 tissue tissue NN cord-009571-mygj2nd4 42 41 disease disease NN cord-009571-mygj2nd4 42 42 ( ( -LRB- cord-009571-mygj2nd4 42 43 MCTD MCTD NNP cord-009571-mygj2nd4 42 44 ) ) -RRB- cord-009571-mygj2nd4 42 45 5/7 5/7 CD cord-009571-mygj2nd4 42 46 , , , cord-009571-mygj2nd4 42 47 other other JJ cord-009571-mygj2nd4 42 48 diseases disease NNS cord-009571-mygj2nd4 42 49 1/10 1/10 CD cord-009571-mygj2nd4 42 50 , , , cord-009571-mygj2nd4 43 1 Thus thus RB cord-009571-mygj2nd4 43 2 far far RB cord-009571-mygj2nd4 43 3 RFs rf NNS cord-009571-mygj2nd4 43 4 reactive reactive JJ cord-009571-mygj2nd4 43 5 with with IN cord-009571-mygj2nd4 43 6 DNP DNP NNP cord-009571-mygj2nd4 43 7 have have VBP cord-009571-mygj2nd4 43 8 not not RB cord-009571-mygj2nd4 43 9 been be VBN cord-009571-mygj2nd4 43 10 found find VBN cord-009571-mygj2nd4 43 11 in in IN cord-009571-mygj2nd4 43 12 systemic systemic JJ cord-009571-mygj2nd4 43 13 lupus lupus NN cord-009571-mygj2nd4 43 14 erythernatosus erythernatosus NN cord-009571-mygj2nd4 43 15 ( ( -LRB- cord-009571-mygj2nd4 43 16 SLE SLE NNP cord-009571-mygj2nd4 43 17 ) ) -RRB- cord-009571-mygj2nd4 43 18 0/8 0/8 CD cord-009571-mygj2nd4 43 19 or or CC cord-009571-mygj2nd4 43 20 essential essential JJ cord-009571-mygj2nd4 43 21 mixed mixed JJ cord-009571-mygj2nd4 43 22 cryoglobulinemia cryoglobulinemia NN cord-009571-mygj2nd4 43 23 0/7 0/7 CD cord-009571-mygj2nd4 43 24 . . . cord-009571-mygj2nd4 44 1 RFs rf NNS cord-009571-mygj2nd4 44 2 which which WDT cord-009571-mygj2nd4 44 3 react react VBP cord-009571-mygj2nd4 44 4 with with IN cord-009571-mygj2nd4 44 5 DNP DNP NNP cord-009571-mygj2nd4 44 6 can can MD cord-009571-mygj2nd4 44 7 give give VB cord-009571-mygj2nd4 44 8 positive positive JJ cord-009571-mygj2nd4 44 9 antinuclear antinuclear JJ cord-009571-mygj2nd4 44 10 antibody antibody NN cord-009571-mygj2nd4 44 11 ( ( -LRB- cord-009571-mygj2nd4 44 12 ANA ANA NNP cord-009571-mygj2nd4 44 13 ) ) -RRB- cord-009571-mygj2nd4 44 14 and and CC cord-009571-mygj2nd4 44 15 LE LE NNP cord-009571-mygj2nd4 44 16 tests test NNS cord-009571-mygj2nd4 44 17 which which WDT cord-009571-mygj2nd4 44 18 can can MD cord-009571-mygj2nd4 44 19 be be VB cord-009571-mygj2nd4 44 20 blocked block VBN cord-009571-mygj2nd4 44 21 by by IN cord-009571-mygj2nd4 44 22 aggregated aggregate VBN cord-009571-mygj2nd4 44 23 IgG igg NN cord-009571-mygj2nd4 44 24 or or CC cord-009571-mygj2nd4 44 25 DNP DNP NNP cord-009571-mygj2nd4 44 26 . . . cord-009571-mygj2nd4 45 1 In in IN cord-009571-mygj2nd4 45 2 contrast contrast NN cord-009571-mygj2nd4 45 3 , , , cord-009571-mygj2nd4 45 4 positive positive JJ cord-009571-mygj2nd4 45 5 ANA ANA NNP cord-009571-mygj2nd4 45 6 and and CC cord-009571-mygj2nd4 45 7 LE LE NNP cord-009571-mygj2nd4 45 8 tests test NNS cord-009571-mygj2nd4 45 9 in in IN cord-009571-mygj2nd4 45 10 SLE SLE NNP cord-009571-mygj2nd4 45 11 are be VBP cord-009571-mygj2nd4 45 12 not not RB cord-009571-mygj2nd4 45 13 blocked block VBN cord-009571-mygj2nd4 45 14 by by IN cord-009571-mygj2nd4 45 15 aggregated aggregate VBN cord-009571-mygj2nd4 45 16 IgG. IgG. NNP cord-009571-mygj2nd4 45 17 Hence Hence NNP cord-009571-mygj2nd4 45 18 RF rf NN cord-009571-mygj2nd4 45 19 induced induce VBN cord-009571-mygj2nd4 45 20 ANA ANA NNP cord-009571-mygj2nd4 45 21 and and CC cord-009571-mygj2nd4 45 22 LE LE NNP cord-009571-mygj2nd4 45 23 tests test NNS cord-009571-mygj2nd4 45 24 may may MD cord-009571-mygj2nd4 45 25 be be VB cord-009571-mygj2nd4 45 26 considered consider VBN cord-009571-mygj2nd4 45 27 " " `` cord-009571-mygj2nd4 45 28 false false JJ cord-009571-mygj2nd4 45 29 " " '' cord-009571-mygj2nd4 45 30 positives positive NNS cord-009571-mygj2nd4 45 31 when when WRB cord-009571-mygj2nd4 45 32 these these DT cord-009571-mygj2nd4 45 33 tests test NNS cord-009571-mygj2nd4 45 34 are be VBP cord-009571-mygj2nd4 45 35 used use VBN cord-009571-mygj2nd4 45 36 in in IN cord-009571-mygj2nd4 45 37 the the DT cord-009571-mygj2nd4 45 38 diagnosis diagnosis NN cord-009571-mygj2nd4 45 39 of of IN cord-009571-mygj2nd4 45 40 SLE SLE NNP cord-009571-mygj2nd4 45 41 . . . cord-009571-mygj2nd4 46 1 In in IN cord-009571-mygj2nd4 46 2 some some DT cord-009571-mygj2nd4 46 3 sera sera NNP cord-009571-mygj2nd4 46 4 these these DT cord-009571-mygj2nd4 46 5 RFs rf NNS cord-009571-mygj2nd4 46 6 could could MD cord-009571-mygj2nd4 46 7 be be VB cord-009571-mygj2nd4 46 8 detected detect VBN cord-009571-mygj2nd4 46 9 only only RB cord-009571-mygj2nd4 46 10 following follow VBG cord-009571-mygj2nd4 46 11 isolation isolation NN cord-009571-mygj2nd4 46 12 with with IN cord-009571-mygj2nd4 46 13 insoluble insoluble JJ cord-009571-mygj2nd4 46 14 IgG igg NN cord-009571-mygj2nd4 46 15 or or CC cord-009571-mygj2nd4 46 16 DNP DNP NNP cord-009571-mygj2nd4 46 17 , , , cord-009571-mygj2nd4 46 18 suggesting suggest VBG cord-009571-mygj2nd4 46 19 the the DT cord-009571-mygj2nd4 46 20 presence presence NN cord-009571-mygj2nd4 46 21 of of IN cord-009571-mygj2nd4 46 22 RFs rf NNS cord-009571-mygj2nd4 46 23 complexed complexe VBN cord-009571-mygj2nd4 46 24 with with IN cord-009571-mygj2nd4 46 25 antigen antigen NN cord-009571-mygj2nd4 46 26 . . . cord-009571-mygj2nd4 47 1 By by IN cord-009571-mygj2nd4 47 2 use use NN cord-009571-mygj2nd4 47 3 of of IN cord-009571-mygj2nd4 47 4 a a DT cord-009571-mygj2nd4 47 5 monoclonal monoclonal JJ cord-009571-mygj2nd4 47 6 R r NN cord-009571-mygj2nd4 47 7 F f NN cord-009571-mygj2nd4 47 8 which which WDT cord-009571-mygj2nd4 47 9 cross cross NN cord-009571-mygj2nd4 47 10 reacts react VBZ cord-009571-mygj2nd4 47 11 with with IN cord-009571-mygj2nd4 47 12 DNF DNF NNP cord-009571-mygj2nd4 47 13 in in IN cord-009571-mygj2nd4 47 14 a a DT cord-009571-mygj2nd4 47 15 sensitive sensitive JJ cord-009571-mygj2nd4 47 16 competitive competitive JJ cord-009571-mygj2nd4 47 17 inhibition inhibition NN cord-009571-mygj2nd4 47 18 radioimmunoassay radioimmunoassay NN cord-009571-mygj2nd4 47 19 designed design VBN cord-009571-mygj2nd4 47 20 for for IN cord-009571-mygj2nd4 47 21 detection detection NN cord-009571-mygj2nd4 47 22 of of IN cord-009571-mygj2nd4 47 23 immune immune JJ cord-009571-mygj2nd4 47 24 complexes complex NNS cord-009571-mygj2nd4 47 25 ( ( -LRB- cord-009571-mygj2nd4 47 26 JCI JCI NNP cord-009571-mygj2nd4 47 27 59:990 59:990 CD cord-009571-mygj2nd4 47 28 , , , cord-009571-mygj2nd4 47 29 1977 1977 CD cord-009571-mygj2nd4 47 30 ) ) -RRB- cord-009571-mygj2nd4 47 31 , , , cord-009571-mygj2nd4 47 32 complexes complex NNS cord-009571-mygj2nd4 47 33 larger large JJR cord-009571-mygj2nd4 47 34 than than IN cord-009571-mygj2nd4 47 35 19s 19 NNS cord-009571-mygj2nd4 47 36 by by IN cord-009571-mygj2nd4 47 37 ultracentrifugation ultracentrifugation NN cord-009571-mygj2nd4 47 38 studies study NNS cord-009571-mygj2nd4 47 39 could could MD cord-009571-mygj2nd4 47 40 be be VB cord-009571-mygj2nd4 47 41 detected detect VBN cord-009571-mygj2nd4 47 42 in in IN cord-009571-mygj2nd4 47 43 several several JJ cord-009571-mygj2nd4 47 44 RA RA NNP cord-009571-mygj2nd4 47 45 sera sera NNP cord-009571-mygj2nd4 47 46 and and CC cord-009571-mygj2nd4 47 47 synovial synovial JJ cord-009571-mygj2nd4 47 48 fluid fluid NN cord-009571-mygj2nd4 47 49 and and CC cord-009571-mygj2nd4 47 50 MCTD MCTD NNP cord-009571-mygj2nd4 47 51 sera sera NNP cord-009571-mygj2nd4 47 52 . . . cord-009571-mygj2nd4 48 1 In in IN cord-009571-mygj2nd4 48 2 some some DT cord-009571-mygj2nd4 48 3 studies study NNS cord-009571-mygj2nd4 49 1 DNAse DNAse NNP cord-009571-mygj2nd4 49 2 treatment treatment NN cord-009571-mygj2nd4 49 3 of of IN cord-009571-mygj2nd4 49 4 these these DT cord-009571-mygj2nd4 49 5 complexes complex NNS cord-009571-mygj2nd4 49 6 resulted result VBD cord-009571-mygj2nd4 49 7 in in IN cord-009571-mygj2nd4 49 8 a a DT cord-009571-mygj2nd4 49 9 decrease decrease NN cord-009571-mygj2nd4 49 10 in in IN cord-009571-mygj2nd4 49 11 size size NN cord-009571-mygj2nd4 49 12 . . . cord-009571-mygj2nd4 50 1 These these DT cord-009571-mygj2nd4 50 2 studies study NNS cord-009571-mygj2nd4 50 3 suggest suggest VBP cord-009571-mygj2nd4 50 4 that that IN cord-009571-mygj2nd4 50 5 complexes complex NNS cord-009571-mygj2nd4 50 6 consisting consist VBG cord-009571-mygj2nd4 50 7 of of IN cord-009571-mygj2nd4 50 8 DNP DNP NNP cord-009571-mygj2nd4 50 9 antigen antigen NN cord-009571-mygj2nd4 50 10 and and CC cord-009571-mygj2nd4 50 11 R R NNP cord-009571-mygj2nd4 50 12 F f NN cord-009571-mygj2nd4 50 13 may may MD cord-009571-mygj2nd4 50 14 be be VB cord-009571-mygj2nd4 50 15 present present JJ cord-009571-mygj2nd4 50 16 in in IN cord-009571-mygj2nd4 50 17 the the DT cord-009571-mygj2nd4 50 18 circulation circulation NN cord-009571-mygj2nd4 50 19 in in IN cord-009571-mygj2nd4 50 20 RA RA NNP cord-009571-mygj2nd4 50 21 and and CC cord-009571-mygj2nd4 50 22 MCTD MCTD NNP cord-009571-mygj2nd4 50 23 . . . cord-009571-mygj2nd4 51 1 The the DT cord-009571-mygj2nd4 51 2 relationship relationship NN cord-009571-mygj2nd4 51 3 , , , cord-009571-mygj2nd4 51 4 if if IN cord-009571-mygj2nd4 51 5 any any DT cord-009571-mygj2nd4 51 6 , , , cord-009571-mygj2nd4 51 7 of of IN cord-009571-mygj2nd4 51 8 these these DT cord-009571-mygj2nd4 51 9 complexes complex NNS cord-009571-mygj2nd4 51 10 to to IN cord-009571-mygj2nd4 51 11 the the DT cord-009571-mygj2nd4 51 12 immunopathology immunopathology NN cord-009571-mygj2nd4 51 13 in in IN cord-009571-mygj2nd4 51 14 these these DT cord-009571-mygj2nd4 51 15 diseases disease NNS cord-009571-mygj2nd4 51 16 is be VBZ cord-009571-mygj2nd4 51 17 currently currently RB cord-009571-mygj2nd4 51 18 under under IN cord-009571-mygj2nd4 51 19 study study NN cord-009571-mygj2nd4 51 20 . . . cord-009571-mygj2nd4 52 1 These these DT cord-009571-mygj2nd4 52 2 studies study NNS cord-009571-mygj2nd4 52 3 also also RB cord-009571-mygj2nd4 52 4 suggest suggest VBP cord-009571-mygj2nd4 52 5 that that IN cord-009571-mygj2nd4 52 6 not not RB cord-009571-mygj2nd4 52 7 all all DT cord-009571-mygj2nd4 52 8 RFs rf NNS cord-009571-mygj2nd4 52 9 may may MD cord-009571-mygj2nd4 52 10 be be VB cord-009571-mygj2nd4 52 11 induced induce VBN cord-009571-mygj2nd4 52 12 by by IN cord-009571-mygj2nd4 52 13 immune immune JJ cord-009571-mygj2nd4 52 14 aggregated aggregated JJ cord-009571-mygj2nd4 52 15 IgG igg NN cord-009571-mygj2nd4 52 16 and and CC cord-009571-mygj2nd4 52 17 that that IN cord-009571-mygj2nd4 52 18 a a DT cord-009571-mygj2nd4 52 19 re re NN cord-009571-mygj2nd4 52 20 - - NN cord-009571-mygj2nd4 52 21 exploration exploration NN cord-009571-mygj2nd4 52 22 of of IN cord-009571-mygj2nd4 52 23 RFs rf NNS cord-009571-mygj2nd4 52 24 in in IN cord-009571-mygj2nd4 52 25 various various JJ cord-009571-mygj2nd4 52 26 diseases disease NNS cord-009571-mygj2nd4 52 27 for for IN cord-009571-mygj2nd4 52 28 cross cross NN cord-009571-mygj2nd4 52 29 reactions reaction NNS cord-009571-mygj2nd4 52 30 with with IN cord-009571-mygj2nd4 52 31 non non JJ cord-009571-mygj2nd4 52 32 - - JJ cord-009571-mygj2nd4 52 33 IgC igc JJ cord-009571-mygj2nd4 52 34 antigens antigen NNS cord-009571-mygj2nd4 52 35 is be VBZ cord-009571-mygj2nd4 52 36 indicated indicate VBN cord-009571-mygj2nd4 52 37 , , , cord-009571-mygj2nd4 52 38 Such such JJ cord-009571-mygj2nd4 52 39 antigen antigen NN cord-009571-mygj2nd4 52 40 may may MD cord-009571-mygj2nd4 52 41 provide provide VB cord-009571-mygj2nd4 52 42 clues clue NNS cord-009571-mygj2nd4 52 43 to to IN cord-009571-mygj2nd4 52 44 etiologic etiologic JJ cord-009571-mygj2nd4 52 45 factors factor NNS cord-009571-mygj2nd4 52 46 in in IN cord-009571-mygj2nd4 52 47 these these DT cord-009571-mygj2nd4 52 48 diseases disease NNS cord-009571-mygj2nd4 52 49 . . . cord-009571-mygj2nd4 53 1 Previous previous JJ cord-009571-mygj2nd4 53 2 studies study NNS cord-009571-mygj2nd4 53 3 demonstrated demonstrate VBD cord-009571-mygj2nd4 53 4 that that IN cord-009571-mygj2nd4 53 5 patients patient NNS cord-009571-mygj2nd4 53 6 with with IN cord-009571-mygj2nd4 53 7 rheumatoid rheumatoid NN cord-009571-mygj2nd4 53 8 arthritis arthritis NN cord-009571-mygj2nd4 53 9 ( ( -LRB- cord-009571-mygj2nd4 53 10 RA RA NNP cord-009571-mygj2nd4 53 11 ) ) -RRB- cord-009571-mygj2nd4 53 12 frequently frequently RB cord-009571-mygj2nd4 53 13 have have VBP cord-009571-mygj2nd4 53 14 an an DT cord-009571-mygj2nd4 53 15 antibody antibody NN cord-009571-mygj2nd4 53 16 referred refer VBN cord-009571-mygj2nd4 53 17 to to IN cord-009571-mygj2nd4 53 18 as as IN cord-009571-mygj2nd4 53 19 rheumatoid rheumatoid NN cord-009571-mygj2nd4 53 20 arthritis arthritis NN cord-009571-mygj2nd4 53 21 precipitin precipitin NNP cord-009571-mygj2nd4 53 22 ( ( -LRB- cord-009571-mygj2nd4 53 23 RAP RAP NNP cord-009571-mygj2nd4 53 24 ) ) -RRB- cord-009571-mygj2nd4 53 25 . . . cord-009571-mygj2nd4 54 1 This this DT cord-009571-mygj2nd4 54 2 antibody antibody NN cord-009571-mygj2nd4 54 3 was be VBD cord-009571-mygj2nd4 54 4 shown show VBN cord-009571-mygj2nd4 54 5 by by IN cord-009571-mygj2nd4 54 6 the the DT cord-009571-mygj2nd4 54 7 indirect indirect JJ cord-009571-mygj2nd4 54 8 immunofluorescent immunofluorescent NN cord-009571-mygj2nd4 54 9 technique technique NN cord-009571-mygj2nd4 54 10 to to TO cord-009571-mygj2nd4 54 11 react react VB cord-009571-mygj2nd4 54 12 with with IN cord-009571-mygj2nd4 54 13 a a DT cord-009571-mygj2nd4 54 14 nuclear nuclear JJ cord-009571-mygj2nd4 54 15 protein protein NN cord-009571-mygj2nd4 54 16 in in IN cord-009571-mygj2nd4 54 17 human human NN cord-009571-mygj2nd4 54 18 , , , cord-009571-mygj2nd4 54 19 B b NN cord-009571-mygj2nd4 54 20 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 54 21 from from IN cord-009571-mygj2nd4 54 22 continuous continuous JJ cord-009571-mygj2nd4 54 23 cell cell NN cord-009571-mygj2nd4 54 24 culture culture NN cord-009571-mygj2nd4 54 25 ( ( -LRB- cord-009571-mygj2nd4 54 26 Wil Wil NNP cord-009571-mygj2nd4 54 27 , , , cord-009571-mygj2nd4 54 28 ) ) -RRB- cord-009571-mygj2nd4 54 29 and and CC cord-009571-mygj2nd4 54 30 the the DT cord-009571-mygj2nd4 54 31 antigen antigen NN cord-009571-mygj2nd4 54 32 was be VBD cord-009571-mygj2nd4 54 33 termed term VBN cord-009571-mygj2nd4 54 34 RA RA NNP cord-009571-mygj2nd4 54 35 associated associate VBN cord-009571-mygj2nd4 54 36 nuclear nuclear JJ cord-009571-mygj2nd4 54 37 antigen antigen NN cord-009571-mygj2nd4 54 38 ( ( -LRB- cord-009571-mygj2nd4 54 39 RANA RANA NNP cord-009571-mygj2nd4 54 40 ) ) -RRB- cord-009571-mygj2nd4 54 41 . . . cord-009571-mygj2nd4 55 1 Infectivity infectivity NN cord-009571-mygj2nd4 55 2 experiments experiment NNS cord-009571-mygj2nd4 55 3 with with IN cord-009571-mygj2nd4 55 4 Epstein Epstein NNP cord-009571-mygj2nd4 55 5 - - HYPH cord-009571-mygj2nd4 55 6 Barr Barr NNP cord-009571-mygj2nd4 55 7 virus virus NN cord-009571-mygj2nd4 55 8 ( ( -LRB- cord-009571-mygj2nd4 55 9 EBV EBV NNP cord-009571-mygj2nd4 55 10 ) ) -RRB- cord-009571-mygj2nd4 55 11 or or CC cord-009571-mygj2nd4 55 12 other other JJ cord-009571-mygj2nd4 55 13 herpes herpes NN cord-009571-mygj2nd4 55 14 viruses virus NNS cord-009571-mygj2nd4 55 15 have have VBP cord-009571-mygj2nd4 55 16 suggested suggest VBN cord-009571-mygj2nd4 55 17 that that IN cord-009571-mygj2nd4 55 18 RANA RANA NNP cord-009571-mygj2nd4 55 19 may may MD cord-009571-mygj2nd4 55 20 be be VB cord-009571-mygj2nd4 55 21 associated associate VBN cord-009571-mygj2nd4 55 22 with with IN cord-009571-mygj2nd4 55 23 EBV EBV NNP cord-009571-mygj2nd4 55 24 infection infection NN cord-009571-mygj2nd4 55 25 ; ; : cord-009571-mygj2nd4 55 26 although although IN cord-009571-mygj2nd4 55 27 RANA RANA NNP cord-009571-mygj2nd4 55 28 shares share VBZ cord-009571-mygj2nd4 55 29 some some DT cord-009571-mygj2nd4 55 30 characteristics characteristic NNS cord-009571-mygj2nd4 55 31 with with IN cord-009571-mygj2nd4 55 32 EB EB NNP cord-009571-mygj2nd4 55 33 nuclear nuclear JJ cord-009571-mygj2nd4 55 34 antigen antigen NN cord-009571-mygj2nd4 55 35 , , , cord-009571-mygj2nd4 55 36 they -PRON- PRP cord-009571-mygj2nd4 55 37 are be VBP cord-009571-mygj2nd4 55 38 probably probably RB cord-009571-mygj2nd4 55 39 two two CD cord-009571-mygj2nd4 55 40 different different JJ cord-009571-mygj2nd4 55 41 antigens antigen NNS cord-009571-mygj2nd4 55 42 . . . cord-009571-mygj2nd4 56 1 In in IN cord-009571-mygj2nd4 56 2 this this DT cord-009571-mygj2nd4 56 3 study study NN cord-009571-mygj2nd4 56 4 we -PRON- PRP cord-009571-mygj2nd4 56 5 have have VBP cord-009571-mygj2nd4 56 6 expanded expand VBN cord-009571-mygj2nd4 56 7 our -PRON- PRP$ cord-009571-mygj2nd4 56 8 work work NN cord-009571-mygj2nd4 56 9 on on IN cord-009571-mygj2nd4 56 10 RANA RANA NNP cord-009571-mygj2nd4 56 11 . . . cord-009571-mygj2nd4 57 1 In in IN cord-009571-mygj2nd4 57 2 addition addition NN cord-009571-mygj2nd4 57 3 to to IN cord-009571-mygj2nd4 57 4 its -PRON- PRP$ cord-009571-mygj2nd4 57 5 presence presence NN cord-009571-mygj2nd4 57 6 in in IN cord-009571-mygj2nd4 57 7 Wil Wil NNP cord-009571-mygj2nd4 57 8 , , , cord-009571-mygj2nd4 57 9 cells cell NNS cord-009571-mygj2nd4 57 10 , , , cord-009571-mygj2nd4 57 11 it -PRON- PRP cord-009571-mygj2nd4 57 12 has have VBZ cord-009571-mygj2nd4 57 13 now now RB cord-009571-mygj2nd4 57 14 been be VBN cord-009571-mygj2nd4 57 15 found find VBN cord-009571-mygj2nd4 57 16 in in IN cord-009571-mygj2nd4 57 17 6 6 CD cord-009571-mygj2nd4 57 18 other other JJ cord-009571-mygj2nd4 57 19 human human NN cord-009571-mygj2nd4 57 20 , , , cord-009571-mygj2nd4 57 21 B B NNP cord-009571-mygj2nd4 57 22 lvmphocyte lvmphocyte NNP cord-009571-mygj2nd4 57 23 lines line NNS cord-009571-mygj2nd4 57 24 but but CC cord-009571-mygj2nd4 57 25 was be VBD cord-009571-mygj2nd4 57 26 not not RB cord-009571-mygj2nd4 57 27 present present JJ cord-009571-mygj2nd4 57 28 in in IN cord-009571-mygj2nd4 57 29 2 2 CD cord-009571-mygj2nd4 57 30 T t NN cord-009571-mygj2nd4 57 31 lymphocyte lymphocyte NN cord-009571-mygj2nd4 57 32 lines line NNS cord-009571-mygj2nd4 57 33 . . . cord-009571-mygj2nd4 58 1 RANA RANA NNP cord-009571-mygj2nd4 58 2 was be VBD cord-009571-mygj2nd4 58 3 not not RB cord-009571-mygj2nd4 58 4 found find VBN cord-009571-mygj2nd4 58 5 in in IN cord-009571-mygj2nd4 58 6 extracts extract NNS cord-009571-mygj2nd4 58 7 from from IN cord-009571-mygj2nd4 58 8 normal normal JJ cord-009571-mygj2nd4 58 9 spleen spleen NN cord-009571-mygj2nd4 58 10 , , , cord-009571-mygj2nd4 58 11 kidney kidney NN cord-009571-mygj2nd4 58 12 , , , cord-009571-mygj2nd4 58 13 heart heart NN cord-009571-mygj2nd4 58 14 , , , cord-009571-mygj2nd4 58 15 or or CC cord-009571-mygj2nd4 58 16 lungs lung NNS cord-009571-mygj2nd4 58 17 , , , cord-009571-mygj2nd4 58 18 or or CC cord-009571-mygj2nd4 58 19 a a DT cord-009571-mygj2nd4 58 20 spleen spleen NN cord-009571-mygj2nd4 58 21 extract extract NN cord-009571-mygj2nd4 58 22 from from IN cord-009571-mygj2nd4 58 23 a a DT cord-009571-mygj2nd4 58 24 patient patient NN cord-009571-mygj2nd4 58 25 with with IN cord-009571-mygj2nd4 58 26 Felty Felty NNP cord-009571-mygj2nd4 58 27 's 's POS cord-009571-mygj2nd4 58 28 RA RA NNP cord-009571-mygj2nd4 58 29 . . . cord-009571-mygj2nd4 59 1 This this DT cord-009571-mygj2nd4 59 2 antigen antigen NN cord-009571-mygj2nd4 59 3 was be VBD cord-009571-mygj2nd4 59 4 not not RB cord-009571-mygj2nd4 59 5 present present JJ cord-009571-mygj2nd4 59 6 in in IN cord-009571-mygj2nd4 59 7 normal normal JJ cord-009571-mygj2nd4 59 8 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 59 9 stimulated stimulate VBN cord-009571-mygj2nd4 59 10 with with IN cord-009571-mygj2nd4 59 11 B B NNP cord-009571-mygj2nd4 59 12 or or CC cord-009571-mygj2nd4 59 13 T T NNP cord-009571-mygj2nd4 59 14 cell cell NN cord-009571-mygj2nd4 59 15 mitogens mitogens NNP cord-009571-mygj2nd4 59 16 . . . cord-009571-mygj2nd4 60 1 RANA RANA NNP cord-009571-mygj2nd4 60 2 was be VBD cord-009571-mygj2nd4 60 3 not not RB cord-009571-mygj2nd4 60 4 found find VBN cord-009571-mygj2nd4 60 5 in in IN cord-009571-mygj2nd4 60 6 peripheral peripheral JJ cord-009571-mygj2nd4 60 7 leukocytes leukocyte NNS cord-009571-mygj2nd4 60 8 from from IN cord-009571-mygj2nd4 60 9 patients patient NNS cord-009571-mygj2nd4 60 10 with with IN cord-009571-mygj2nd4 60 11 RA RA NNP cord-009571-mygj2nd4 60 12 . . . cord-009571-mygj2nd4 61 1 However however RB cord-009571-mygj2nd4 61 2 , , , cord-009571-mygj2nd4 61 3 it -PRON- PRP cord-009571-mygj2nd4 61 4 was be VBD cord-009571-mygj2nd4 61 5 found find VBN cord-009571-mygj2nd4 61 6 in in IN cord-009571-mygj2nd4 61 7 2 2 CD cord-009571-mygj2nd4 61 8 of of IN cord-009571-mygj2nd4 61 9 3 3 CD cord-009571-mygj2nd4 61 10 extracts extract NNS cord-009571-mygj2nd4 61 11 made make VBN cord-009571-mygj2nd4 61 12 from from IN cord-009571-mygj2nd4 61 13 pannus pannus NN cord-009571-mygj2nd4 61 14 layers layer NNS cord-009571-mygj2nd4 61 15 and and CC cord-009571-mygj2nd4 61 16 an an DT cord-009571-mygj2nd4 61 17 extract extract NN cord-009571-mygj2nd4 61 18 made make VBN cord-009571-mygj2nd4 61 19 from from IN cord-009571-mygj2nd4 61 20 nodules nodule NNS cord-009571-mygj2nd4 61 21 taken take VBN cord-009571-mygj2nd4 61 22 from from IN cord-009571-mygj2nd4 61 23 patients patient NNS cord-009571-mygj2nd4 61 24 with with IN cord-009571-mygj2nd4 61 25 seropositive seropositive JJ cord-009571-mygj2nd4 61 26 RA ra NN cord-009571-mygj2nd4 61 27 but but CC cord-009571-mygj2nd4 61 28 was be VBD cord-009571-mygj2nd4 61 29 not not RB cord-009571-mygj2nd4 61 30 present present JJ cord-009571-mygj2nd4 61 31 in in IN cord-009571-mygj2nd4 61 32 2 2 CD cord-009571-mygj2nd4 61 33 extracts extract NNS cord-009571-mygj2nd4 61 34 made make VBN cord-009571-mygj2nd4 61 35 from from IN cord-009571-mygj2nd4 61 36 pannus pannus NN cord-009571-mygj2nd4 61 37 layers layer NNS cord-009571-mygj2nd4 61 38 taken take VBN cord-009571-mygj2nd4 61 39 from from IN cord-009571-mygj2nd4 61 40 seronegative seronegative JJ cord-009571-mygj2nd4 61 41 RA RA NNP cord-009571-mygj2nd4 61 42 patients patient NNS cord-009571-mygj2nd4 61 43 and and CC cord-009571-mygj2nd4 61 44 synovium synovium VBD cord-009571-mygj2nd4 61 45 from from IN cord-009571-mygj2nd4 61 46 a a DT cord-009571-mygj2nd4 61 47 traumatized traumatize VBN cord-009571-mygj2nd4 61 48 joint joint NN cord-009571-mygj2nd4 61 49 . . . cord-009571-mygj2nd4 62 1 Initial initial JJ cord-009571-mygj2nd4 62 2 physicobiochemical physicobiochemical JJ cord-009571-mygj2nd4 62 3 characterization characterization NN cord-009571-mygj2nd4 62 4 of of IN cord-009571-mygj2nd4 62 5 RANA RANA NNP cord-009571-mygj2nd4 62 6 demonstrated demonstrate VBD cord-009571-mygj2nd4 62 7 that that IN cord-009571-mygj2nd4 62 8 it -PRON- PRP cord-009571-mygj2nd4 62 9 was be VBD cord-009571-mygj2nd4 62 10 stable stable JJ cord-009571-mygj2nd4 62 11 to to TO cord-009571-mygj2nd4 62 12 heat heat NN cord-009571-mygj2nd4 62 13 ( ( -LRB- cord-009571-mygj2nd4 62 14 37OC 37oc CD cord-009571-mygj2nd4 62 15 or or CC cord-009571-mygj2nd4 62 16 56OC 56oc CD cord-009571-mygj2nd4 62 17 ) ) -RRB- cord-009571-mygj2nd4 62 18 or or CC cord-009571-mygj2nd4 62 19 cold cold JJ cord-009571-mygj2nd4 62 20 ( ( -LRB- cord-009571-mygj2nd4 62 21 4 4 CD cord-009571-mygj2nd4 62 22 O o NN cord-009571-mygj2nd4 62 23 to to IN cord-009571-mygj2nd4 62 24 -7OOC -7ooc NN cord-009571-mygj2nd4 62 25 ) ) -RRB- cord-009571-mygj2nd4 62 26 treatments treatment NNS cord-009571-mygj2nd4 62 27 or or CC cord-009571-mygj2nd4 62 28 at at IN cord-009571-mygj2nd4 62 29 pH pH NNP cord-009571-mygj2nd4 62 30 values value NNS cord-009571-mygj2nd4 62 31 of of IN cord-009571-mygj2nd4 62 32 pH pH NNP cord-009571-mygj2nd4 62 33 6.2 6.2 CD cord-009571-mygj2nd4 62 34 - - HYPH cord-009571-mygj2nd4 62 35 8.6 8.6 CD cord-009571-mygj2nd4 62 36 . . . cord-009571-mygj2nd4 63 1 Studies study NNS cord-009571-mygj2nd4 63 2 performed perform VBN cord-009571-mygj2nd4 63 3 by by IN cord-009571-mygj2nd4 63 4 immunoelectrophoresis immunoelectrophoresis NNP cord-009571-mygj2nd4 63 5 indicated indicate VBD cord-009571-mygj2nd4 63 6 that that IN cord-009571-mygj2nd4 63 7 RANA RANA NNP cord-009571-mygj2nd4 63 8 was be VBD cord-009571-mygj2nd4 63 9 an an DT cord-009571-mygj2nd4 63 10 anion anion NN cord-009571-mygj2nd4 63 11 at at IN cord-009571-mygj2nd4 63 12 pH pH NNP cord-009571-mygj2nd4 63 13 7.4 7.4 CD cord-009571-mygj2nd4 63 14 - - HYPH cord-009571-mygj2nd4 63 15 8.6 8.6 CD cord-009571-mygj2nd4 63 16 . . . cord-009571-mygj2nd4 64 1 Will Will MD cord-009571-mygj2nd4 64 2 extracts extract NNS cord-009571-mygj2nd4 64 3 were be VBD cord-009571-mygj2nd4 64 4 separated separate VBN cord-009571-mygj2nd4 64 5 on on IN cord-009571-mygj2nd4 64 6 a a DT cord-009571-mygj2nd4 64 7 calibrated calibrate VBN cord-009571-mygj2nd4 64 8 10 10 CD cord-009571-mygj2nd4 64 9 % % NN cord-009571-mygj2nd4 64 10 agarose agarose JJ cord-009571-mygj2nd4 64 11 column column NN cord-009571-mygj2nd4 64 12 and and CC cord-009571-mygj2nd4 64 13 the the DT cord-009571-mygj2nd4 64 14 molecular molecular JJ cord-009571-mygj2nd4 64 15 weight weight NN cord-009571-mygj2nd4 64 16 estimated estimate VBN cord-009571-mygj2nd4 64 17 at at IN cord-009571-mygj2nd4 64 18 120,000 120,000 CD cord-009571-mygj2nd4 64 19 d. d. NNP cord-009571-mygj2nd4 65 1 In in IN cord-009571-mygj2nd4 65 2 other other JJ cord-009571-mygj2nd4 65 3 studies study NNS cord-009571-mygj2nd4 65 4 the the DT cord-009571-mygj2nd4 65 5 antigen antigen NN cord-009571-mygj2nd4 65 6 could could MD cord-009571-mygj2nd4 65 7 not not RB cord-009571-mygj2nd4 65 8 be be VB cord-009571-mygj2nd4 65 9 detected detect VBN cord-009571-mygj2nd4 65 10 on on IN cord-009571-mygj2nd4 65 11 the the DT cord-009571-mygj2nd4 65 12 surface surface NN cord-009571-mygj2nd4 65 13 of of IN cord-009571-mygj2nd4 65 14 Wil Wil NNP cord-009571-mygj2nd4 65 15 , , , cord-009571-mygj2nd4 65 16 cells cell NNS cord-009571-mygj2nd4 65 17 . . . cord-009571-mygj2nd4 66 1 Immunodiffusion Immunodiffusion NNP cord-009571-mygj2nd4 66 2 studies study NNS cord-009571-mygj2nd4 66 3 using use VBG cord-009571-mygj2nd4 66 4 Burkitt Burkitt NNP cord-009571-mygj2nd4 66 5 's 's POS cord-009571-mygj2nd4 66 6 lymphoma lymphoma NN cord-009571-mygj2nd4 66 7 sera sera NNP cord-009571-mygj2nd4 66 8 ( ( -LRB- cord-009571-mygj2nd4 66 9 12 12 CD cord-009571-mygj2nd4 66 10 ) ) -RRB- cord-009571-mygj2nd4 66 11 or or CC cord-009571-mygj2nd4 66 12 nasopharyngeal nasopharyngeal JJ cord-009571-mygj2nd4 66 13 carcinoma carcinoma FW cord-009571-mygj2nd4 66 14 sera sera NNP cord-009571-mygj2nd4 66 15 ( ( -LRB- cord-009571-mygj2nd4 66 16 12 12 CD cord-009571-mygj2nd4 66 17 ) ) -RRB- cord-009571-mygj2nd4 66 18 containing contain VBG cord-009571-mygj2nd4 66 19 high high JJ cord-009571-mygj2nd4 66 20 titers titer NNS cord-009571-mygj2nd4 66 21 of of IN cord-009571-mygj2nd4 66 22 EBV EBV NNP cord-009571-mygj2nd4 66 23 antibodies antibody NNS cord-009571-mygj2nd4 66 24 to to IN cord-009571-mygj2nd4 66 25 : : : cord-009571-mygj2nd4 66 26 viral viral JJ cord-009571-mygj2nd4 66 27 capsid capsid NN cord-009571-mygj2nd4 66 28 antigen antigen NN cord-009571-mygj2nd4 66 29 or or CC cord-009571-mygj2nd4 66 30 early early JJ cord-009571-mygj2nd4 66 31 antigens antigen NNS cord-009571-mygj2nd4 66 32 D d NN cord-009571-mygj2nd4 66 33 or or CC cord-009571-mygj2nd4 66 34 R r NN cord-009571-mygj2nd4 66 35 do do VBP cord-009571-mygj2nd4 66 36 not not RB cord-009571-mygj2nd4 66 37 react react VB cord-009571-mygj2nd4 66 38 with with IN cord-009571-mygj2nd4 66 39 Wil Wil NNP cord-009571-mygj2nd4 66 40 , , , cord-009571-mygj2nd4 66 41 extract extract VB cord-009571-mygj2nd4 66 42 , , , cord-009571-mygj2nd4 66 43 suggesting suggest VBG cord-009571-mygj2nd4 66 44 these these DT cord-009571-mygj2nd4 66 45 EBV EBV NNP cord-009571-mygj2nd4 66 46 antigens antigen NNS cord-009571-mygj2nd4 66 47 are be VBP cord-009571-mygj2nd4 66 48 not not RB cord-009571-mygj2nd4 66 49 present present JJ cord-009571-mygj2nd4 66 50 in in IN cord-009571-mygj2nd4 66 51 the the DT cord-009571-mygj2nd4 66 52 extract extract NN cord-009571-mygj2nd4 66 53 and and CC cord-009571-mygj2nd4 66 54 therefore therefore RB cord-009571-mygj2nd4 66 55 can can MD cord-009571-mygj2nd4 66 56 not not RB cord-009571-mygj2nd4 66 57 be be VB cord-009571-mygj2nd4 66 58 RANA RANA NNP cord-009571-mygj2nd4 66 59 . . . cord-009571-mygj2nd4 67 1 The the DT cord-009571-mygj2nd4 67 2 data datum NNS cord-009571-mygj2nd4 67 3 suggest suggest VBP cord-009571-mygj2nd4 67 4 that that IN cord-009571-mygj2nd4 67 5 RANA RANA NNP cord-009571-mygj2nd4 67 6 may may MD cord-009571-mygj2nd4 67 7 be be VB cord-009571-mygj2nd4 67 8 a a DT cord-009571-mygj2nd4 67 9 new new JJ cord-009571-mygj2nd4 67 10 , , , cord-009571-mygj2nd4 67 11 heat heat NN cord-009571-mygj2nd4 67 12 stable stable JJ cord-009571-mygj2nd4 67 13 , , , cord-009571-mygj2nd4 67 14 acidic acidic JJ cord-009571-mygj2nd4 67 15 , , , cord-009571-mygj2nd4 67 16 nuclear nuclear JJ cord-009571-mygj2nd4 67 17 protein protein NN cord-009571-mygj2nd4 67 18 associated associate VBN cord-009571-mygj2nd4 67 19 with with IN cord-009571-mygj2nd4 67 20 EBV EBV NNP cord-009571-mygj2nd4 67 21 infection infection NN cord-009571-mygj2nd4 67 22 which which WDT cord-009571-mygj2nd4 67 23 could could MD cord-009571-mygj2nd4 67 24 be be VB cord-009571-mygj2nd4 67 25 important important JJ cord-009571-mygj2nd4 67 26 in in IN cord-009571-mygj2nd4 67 27 the the DT cord-009571-mygj2nd4 67 28 pathogenesis pathogenesis NN cord-009571-mygj2nd4 67 29 of of IN cord-009571-mygj2nd4 67 30 RA RA NNP cord-009571-mygj2nd4 67 31 . . . cord-009571-mygj2nd4 68 1 After after IN cord-009571-mygj2nd4 68 2 medical medical JJ cord-009571-mygj2nd4 68 3 workup workup NN cord-009571-mygj2nd4 68 4 , , , cord-009571-mygj2nd4 68 5 arthroscopy arthroscopy NN cord-009571-mygj2nd4 68 6 was be VBD cord-009571-mygj2nd4 68 7 performed perform VBN cord-009571-mygj2nd4 68 8 on on IN cord-009571-mygj2nd4 68 9 100 100 CD cord-009571-mygj2nd4 68 10 patients patient NNS cord-009571-mygj2nd4 68 11 ( ( -LRB- cord-009571-mygj2nd4 68 12 5 5 CD cord-009571-mygj2nd4 68 13 : : SYM cord-009571-mygj2nd4 68 14 2 2 CD cord-009571-mygj2nd4 68 15 , , , cord-009571-mygj2nd4 68 16 men man NNS cord-009571-mygj2nd4 68 17 : : : cord-009571-mygj2nd4 68 18 women woman NNS cord-009571-mygj2nd4 68 19 ; ; : cord-009571-mygj2nd4 68 20 ages age NNS cord-009571-mygj2nd4 68 21 14 14 CD cord-009571-mygj2nd4 68 22 - - SYM cord-009571-mygj2nd4 68 23 74 74 CD cord-009571-mygj2nd4 68 24 ) ) -RRB- cord-009571-mygj2nd4 68 25 with with IN cord-009571-mygj2nd4 68 26 painful painful JJ cord-009571-mygj2nd4 68 27 knees knee NNS cord-009571-mygj2nd4 68 28 of of IN cord-009571-mygj2nd4 68 29 unknown unknown JJ cord-009571-mygj2nd4 68 30 cause cause NN cord-009571-mygj2nd4 68 31 . . . cord-009571-mygj2nd4 69 1 Arthroscopy arthroscopy NN cord-009571-mygj2nd4 69 2 of of IN cord-009571-mygj2nd4 69 3 the the DT cord-009571-mygj2nd4 69 4 knee knee NN cord-009571-mygj2nd4 69 5 was be VBD cord-009571-mygj2nd4 69 6 achieved achieve VBN cord-009571-mygj2nd4 69 7 on on IN cord-009571-mygj2nd4 69 8 ambulant ambulant JJ cord-009571-mygj2nd4 69 9 patients patient NNS cord-009571-mygj2nd4 69 10 under under IN cord-009571-mygj2nd4 69 11 sterile sterile JJ cord-009571-mygj2nd4 69 12 technique technique NN cord-009571-mygj2nd4 69 13 in in IN cord-009571-mygj2nd4 69 14 an an DT cord-009571-mygj2nd4 69 15 outpatient outpatient JJ cord-009571-mygj2nd4 69 16 minor minor JJ cord-009571-mygj2nd4 69 17 surgery surgery NN cord-009571-mygj2nd4 69 18 suite suite NN cord-009571-mygj2nd4 69 19 utilizing utilize VBG cord-009571-mygj2nd4 69 20 a a DT cord-009571-mygj2nd4 69 21 Needlescope Needlescope NNP cord-009571-mygj2nd4 69 22 or or CC cord-009571-mygj2nd4 69 23 Watanabe Watanabe NNP cord-009571-mygj2nd4 69 24 521 521 CD cord-009571-mygj2nd4 69 25 Arthroscope Arthroscope NNP cord-009571-mygj2nd4 69 26 . . . cord-009571-mygj2nd4 70 1 Biopsies biopsy NNS cord-009571-mygj2nd4 70 2 were be VBD cord-009571-mygj2nd4 70 3 guided guide VBN cord-009571-mygj2nd4 70 4 by by IN cord-009571-mygj2nd4 70 5 visualization visualization NN cord-009571-mygj2nd4 70 6 . . . cord-009571-mygj2nd4 71 1 Postarthroscopy Postarthroscopy NNP cord-009571-mygj2nd4 71 2 diagnoses diagnosis NNS cord-009571-mygj2nd4 71 3 are be VBP cord-009571-mygj2nd4 71 4 reflected reflect VBN cord-009571-mygj2nd4 71 5 in in IN cord-009571-mygj2nd4 71 6 the the DT cord-009571-mygj2nd4 71 7 table table NN cord-009571-mygj2nd4 71 8 . . . cord-009571-mygj2nd4 72 1 In in IN cord-009571-mygj2nd4 72 2 most most JJS cord-009571-mygj2nd4 72 3 cases case NNS cord-009571-mygj2nd4 72 4 the the DT cord-009571-mygj2nd4 72 5 procedure procedure NN cord-009571-mygj2nd4 72 6 allowed allow VBD cord-009571-mygj2nd4 72 7 adequate adequate JJ cord-009571-mygj2nd4 72 8 visualization visualization NN cord-009571-mygj2nd4 72 9 of of IN cord-009571-mygj2nd4 72 10 the the DT cord-009571-mygj2nd4 72 11 suprapatellar suprapatellar NNP cord-009571-mygj2nd4 72 12 sac sac NN cord-009571-mygj2nd4 72 13 , , , cord-009571-mygj2nd4 72 14 articular articular JJ cord-009571-mygj2nd4 72 15 cartilage cartilage NN cord-009571-mygj2nd4 72 16 , , , cord-009571-mygj2nd4 72 17 menisci meniscus NNS cord-009571-mygj2nd4 72 18 , , , cord-009571-mygj2nd4 72 19 anterior anterior JJ cord-009571-mygj2nd4 72 20 cruciate cruciate NN cord-009571-mygj2nd4 72 21 , , , cord-009571-mygj2nd4 72 22 and and CC cord-009571-mygj2nd4 72 23 synovial synovial JJ cord-009571-mygj2nd4 72 24 lining lining NN cord-009571-mygj2nd4 72 25 . . . cord-009571-mygj2nd4 73 1 No no DT cord-009571-mygj2nd4 73 2 arthroscopic arthroscopic JJ cord-009571-mygj2nd4 73 3 abnormality abnormality NN cord-009571-mygj2nd4 73 4 was be VBD cord-009571-mygj2nd4 73 5 visualized visualize VBN cord-009571-mygj2nd4 73 6 in in IN cord-009571-mygj2nd4 73 7 12 12 CD cord-009571-mygj2nd4 73 8 % % NN cord-009571-mygj2nd4 73 9 . . . cord-009571-mygj2nd4 74 1 Nearly nearly RB cord-009571-mygj2nd4 74 2 half half NN cord-009571-mygj2nd4 74 3 of of IN cord-009571-mygj2nd4 74 4 the the DT cord-009571-mygj2nd4 74 5 patients patient NNS cord-009571-mygj2nd4 74 6 had have VBD cord-009571-mygj2nd4 74 7 osteoarthritis osteoarthritis NN cord-009571-mygj2nd4 74 8 including include VBG cord-009571-mygj2nd4 74 9 12 12 CD cord-009571-mygj2nd4 74 10 patients patient NNS cord-009571-mygj2nd4 74 11 with with IN cord-009571-mygj2nd4 74 12 chondromalacia chondromalacia FW cord-009571-mygj2nd4 74 13 patella patella NN cord-009571-mygj2nd4 74 14 . . . cord-009571-mygj2nd4 75 1 The the DT cord-009571-mygj2nd4 75 2 group group NN cord-009571-mygj2nd4 75 3 with with IN cord-009571-mygj2nd4 75 4 osteoarthritis osteoarthritis NN cord-009571-mygj2nd4 75 5 also also RB cord-009571-mygj2nd4 75 6 included include VBD cord-009571-mygj2nd4 75 7 9 9 CD cord-009571-mygj2nd4 75 8 patients patient NNS cord-009571-mygj2nd4 75 9 who who WP cord-009571-mygj2nd4 75 10 had have VBD cord-009571-mygj2nd4 75 11 at at RB cord-009571-mygj2nd4 75 12 least least RBS cord-009571-mygj2nd4 75 13 one one CD cord-009571-mygj2nd4 75 14 torn tear VBN cord-009571-mygj2nd4 75 15 meniscus meniscus NN cord-009571-mygj2nd4 75 16 . . . cord-009571-mygj2nd4 76 1 Septic septic JJ cord-009571-mygj2nd4 76 2 arthritis arthritis NN cord-009571-mygj2nd4 76 3 was be VBD cord-009571-mygj2nd4 76 4 confirmed confirm VBN cord-009571-mygj2nd4 76 5 in in IN cord-009571-mygj2nd4 76 6 4 4 CD cord-009571-mygj2nd4 76 7 % % NN cord-009571-mygj2nd4 76 8 by by IN cord-009571-mygj2nd4 76 9 synovial synovial JJ cord-009571-mygj2nd4 76 10 biopsy biopsy NN cord-009571-mygj2nd4 76 11 including include VBG cord-009571-mygj2nd4 76 12 one one CD cord-009571-mygj2nd4 76 13 case case NN cord-009571-mygj2nd4 76 14 of of IN cord-009571-mygj2nd4 76 15 tuberculosis tuberculosis NN cord-009571-mygj2nd4 76 16 . . . cord-009571-mygj2nd4 77 1 Previous previous JJ cord-009571-mygj2nd4 77 2 undiagnosed undiagnosed JJ cord-009571-mygj2nd4 77 3 synovitis synovitis NN cord-009571-mygj2nd4 77 4 was be VBD cord-009571-mygj2nd4 77 5 confirmed confirm VBN cord-009571-mygj2nd4 77 6 but but CC cord-009571-mygj2nd4 77 7 not not RB cord-009571-mygj2nd4 77 8 further further RB cord-009571-mygj2nd4 77 9 defined define VBN cord-009571-mygj2nd4 77 10 in in IN cord-009571-mygj2nd4 77 11 4 4 CD cord-009571-mygj2nd4 77 12 patients patient NNS cord-009571-mygj2nd4 77 13 . . . cord-009571-mygj2nd4 78 1 Four four CD cord-009571-mygj2nd4 78 2 biopsies biopsy NNS cord-009571-mygj2nd4 78 3 suggested suggest VBD cord-009571-mygj2nd4 78 4 rheumatoid rheumatoid NNP cord-009571-mygj2nd4 78 5 synovitis synovitis NNP cord-009571-mygj2nd4 78 6 ; ; : cord-009571-mygj2nd4 78 7 the the DT cord-009571-mygj2nd4 78 8 diagnosis diagnosis NN cord-009571-mygj2nd4 78 9 was be VBD cord-009571-mygj2nd4 78 10 confirmed confirm VBN cord-009571-mygj2nd4 78 11 by by IN cord-009571-mygj2nd4 78 12 subsequent subsequent JJ cord-009571-mygj2nd4 78 13 clinical clinical JJ cord-009571-mygj2nd4 78 14 and and CC cord-009571-mygj2nd4 78 15 laboratory laboratory NN cord-009571-mygj2nd4 78 16 course course NN cord-009571-mygj2nd4 78 17 . . . cord-009571-mygj2nd4 79 1 Results result NNS cord-009571-mygj2nd4 79 2 of of IN cord-009571-mygj2nd4 79 3 arthrography arthrography NN cord-009571-mygj2nd4 79 4 ( ( -LRB- cord-009571-mygj2nd4 79 5 46 46 CD cord-009571-mygj2nd4 79 6 ) ) -RRB- cord-009571-mygj2nd4 79 7 were be VBD cord-009571-mygj2nd4 79 8 confirmed confirm VBN cord-009571-mygj2nd4 79 9 in in IN cord-009571-mygj2nd4 79 10 26 26 CD cord-009571-mygj2nd4 79 11 , , , cord-009571-mygj2nd4 79 12 contradicted contradict VBN cord-009571-mygj2nd4 79 13 in in IN cord-009571-mygj2nd4 79 14 12 12 CD cord-009571-mygj2nd4 79 15 , , , cord-009571-mygj2nd4 79 16 and and CC cord-009571-mygj2nd4 79 17 provided provide VBD cord-009571-mygj2nd4 79 18 additional additional JJ cord-009571-mygj2nd4 79 19 findings finding NNS cord-009571-mygj2nd4 79 20 in in IN cord-009571-mygj2nd4 79 21 2 2 CD cord-009571-mygj2nd4 79 22 I. I. NNP cord-009571-mygj2nd4 79 23 Patients patient NNS cord-009571-mygj2nd4 79 24 were be VBD cord-009571-mygj2nd4 79 25 ambulant ambulant JJ cord-009571-mygj2nd4 79 26 after after IN cord-009571-mygj2nd4 79 27 the the DT cord-009571-mygj2nd4 79 28 procedure procedure NN cord-009571-mygj2nd4 79 29 with with IN cord-009571-mygj2nd4 79 30 minimal minimal JJ cord-009571-mygj2nd4 79 31 morbidity-6 morbidity-6 NNP cord-009571-mygj2nd4 79 32 hemarthroses hemarthrose NNS cord-009571-mygj2nd4 79 33 and and CC cord-009571-mygj2nd4 79 34 an an DT cord-009571-mygj2nd4 79 35 acute acute JJ cord-009571-mygj2nd4 79 36 pseudogout pseudogout NN cord-009571-mygj2nd4 79 37 , , , cord-009571-mygj2nd4 79 38 all all DT cord-009571-mygj2nd4 79 39 treated treat VBN cord-009571-mygj2nd4 79 40 by by IN cord-009571-mygj2nd4 79 41 arthrocentesis arthrocentesis NNP cord-009571-mygj2nd4 79 42 . . . cord-009571-mygj2nd4 80 1 The the DT cord-009571-mygj2nd4 80 2 gainful gainful JJ cord-009571-mygj2nd4 80 3 knee knee NN cord-009571-mygj2nd4 80 4 often often RB cord-009571-mygj2nd4 80 5 presents present VBZ cord-009571-mygj2nd4 80 6 a a DT cord-009571-mygj2nd4 80 7 diagnostic diagnostic JJ cord-009571-mygj2nd4 80 8 enigma enigma NN cord-009571-mygj2nd4 80 9 particularly particularly RB cord-009571-mygj2nd4 80 10 when when WRB cord-009571-mygj2nd4 80 11 degree degree NN cord-009571-mygj2nd4 80 12 of of IN cord-009571-mygj2nd4 80 13 disability disability NN cord-009571-mygj2nd4 80 14 is be VBZ cord-009571-mygj2nd4 80 15 a a DT cord-009571-mygj2nd4 80 16 question question NN cord-009571-mygj2nd4 80 17 . . . cord-009571-mygj2nd4 81 1 Ar Ar NNP cord-009571-mygj2nd4 81 2 - - HYPH cord-009571-mygj2nd4 81 3 throscopy throscopy NN cord-009571-mygj2nd4 81 4 is be VBZ cord-009571-mygj2nd4 81 5 a a DT cord-009571-mygj2nd4 81 6 safe safe JJ cord-009571-mygj2nd4 81 7 minor minor JJ cord-009571-mygj2nd4 81 8 surgery surgery NN cord-009571-mygj2nd4 81 9 procedure procedure NN cord-009571-mygj2nd4 81 10 that that WDT cord-009571-mygj2nd4 81 11 may may MD cord-009571-mygj2nd4 81 12 reveal reveal VB cord-009571-mygj2nd4 81 13 the the DT cord-009571-mygj2nd4 81 14 underlying underlying JJ cord-009571-mygj2nd4 81 15 cause cause NN cord-009571-mygj2nd4 81 16 of of IN cord-009571-mygj2nd4 81 17 pain pain NN cord-009571-mygj2nd4 81 18 and and CC cord-009571-mygj2nd4 81 19 preclude preclude VB cord-009571-mygj2nd4 81 20 the the DT cord-009571-mygj2nd4 81 21 need need NN cord-009571-mygj2nd4 81 22 for for IN cord-009571-mygj2nd4 81 23 arthrotomy arthrotomy NN cord-009571-mygj2nd4 81 24 . . . cord-009571-mygj2nd4 82 1 Diagnosis Diagnosis NNP cord-009571-mygj2nd4 82 2 _SP cord-009571-mygj2nd4 82 3 Computer Computer NNP cord-009571-mygj2nd4 82 4 assisted assist VBD cord-009571-mygj2nd4 82 5 tomography tomography NN cord-009571-mygj2nd4 82 6 of of IN cord-009571-mygj2nd4 82 7 the the DT cord-009571-mygj2nd4 82 8 spine spine NN cord-009571-mygj2nd4 82 9 and/or and/or CC cord-009571-mygj2nd4 82 10 roentgenographic roentgenographic NNP cord-009571-mygj2nd4 83 1 transaxial transaxial NNP cord-009571-mygj2nd4 83 2 lumbar lumbar NNP cord-009571-mygj2nd4 83 3 tomography tomography NN cord-009571-mygj2nd4 83 4 were be VBD cord-009571-mygj2nd4 83 5 performed perform VBN cord-009571-mygj2nd4 83 6 on on IN cord-009571-mygj2nd4 83 7 25 25 CD cord-009571-mygj2nd4 83 8 patients patient NNS cord-009571-mygj2nd4 83 9 ( ( -LRB- cord-009571-mygj2nd4 83 10 age age NN cord-009571-mygj2nd4 83 11 69 69 CD cord-009571-mygj2nd4 83 12 iz iz NN cord-009571-mygj2nd4 83 13 12 12 CD cord-009571-mygj2nd4 83 14 SD sd NN cord-009571-mygj2nd4 83 15 years year NNS cord-009571-mygj2nd4 83 16 ) ) -RRB- cord-009571-mygj2nd4 83 17 with with IN cord-009571-mygj2nd4 83 18 back back JJ cord-009571-mygj2nd4 83 19 pain pain NN cord-009571-mygj2nd4 83 20 and and CC cord-009571-mygj2nd4 83 21 concomitant concomitant JJ cord-009571-mygj2nd4 83 22 Paget Paget NNP cord-009571-mygj2nd4 83 23 's 's POS cord-009571-mygj2nd4 83 24 disease disease NN cord-009571-mygj2nd4 83 25 . . . cord-009571-mygj2nd4 84 1 Clinical clinical JJ cord-009571-mygj2nd4 84 2 assessment assessment NN cord-009571-mygj2nd4 84 3 with with IN cord-009571-mygj2nd4 84 4 routine routine JJ cord-009571-mygj2nd4 84 5 lumbosacral lumbosacral NNP cord-009571-mygj2nd4 84 6 x x NNS cord-009571-mygj2nd4 84 7 - - NNS cord-009571-mygj2nd4 84 8 rays ray NNS cord-009571-mygj2nd4 84 9 was be VBD cord-009571-mygj2nd4 84 10 performed perform VBN cord-009571-mygj2nd4 84 11 by by IN cord-009571-mygj2nd4 84 12 a a DT cord-009571-mygj2nd4 84 13 rheumatologist rheumatologist NN cord-009571-mygj2nd4 84 14 and and CC cord-009571-mygj2nd4 84 15 an an DT cord-009571-mygj2nd4 84 16 orthopedic orthopedic JJ cord-009571-mygj2nd4 84 17 surgeon surgeon NN cord-009571-mygj2nd4 84 18 . . . cord-009571-mygj2nd4 85 1 Both both DT cord-009571-mygj2nd4 85 2 tomographic tomographic JJ cord-009571-mygj2nd4 85 3 methods method NNS cord-009571-mygj2nd4 85 4 are be VBP cord-009571-mygj2nd4 85 5 xray xray NN cord-009571-mygj2nd4 85 6 techniques technique NNS cord-009571-mygj2nd4 85 7 that that WDT cord-009571-mygj2nd4 85 8 transect transect VBP cord-009571-mygj2nd4 85 9 the the DT cord-009571-mygj2nd4 85 10 spinal spinal JJ cord-009571-mygj2nd4 85 11 canal canal NN cord-009571-mygj2nd4 85 12 and and CC cord-009571-mygj2nd4 85 13 the the DT cord-009571-mygj2nd4 85 14 intervertebral intervertebral JJ cord-009571-mygj2nd4 85 15 foramina foramina NNPS cord-009571-mygj2nd4 85 16 producing produce VBG cord-009571-mygj2nd4 85 17 a a DT cord-009571-mygj2nd4 85 18 computer computer NN cord-009571-mygj2nd4 85 19 printout printout NN cord-009571-mygj2nd4 85 20 or or CC cord-009571-mygj2nd4 85 21 laminogram laminogram VBP cord-009571-mygj2nd4 85 22 along along IN cord-009571-mygj2nd4 85 23 the the DT cord-009571-mygj2nd4 85 24 axial axial JJ cord-009571-mygj2nd4 85 25 plane plane NN cord-009571-mygj2nd4 85 26 of of IN cord-009571-mygj2nd4 85 27 the the DT cord-009571-mygj2nd4 85 28 spine spine NN cord-009571-mygj2nd4 85 29 . . . cord-009571-mygj2nd4 86 1 The the DT cord-009571-mygj2nd4 86 2 following following NN cord-009571-mygj2nd4 86 3 was be VBD cord-009571-mygj2nd4 86 4 found find VBN cord-009571-mygj2nd4 86 5 : : : cord-009571-mygj2nd4 86 6 1 1 CD cord-009571-mygj2nd4 86 7 . . . cord-009571-mygj2nd4 87 1 Spinal spinal JJ cord-009571-mygj2nd4 87 2 stenosis stenosis NN cord-009571-mygj2nd4 87 3 : : : cord-009571-mygj2nd4 88 1 spondylotic spondylotic NNP cord-009571-mygj2nd4 88 2 osteophytes osteophytes NNP cord-009571-mygj2nd4 88 3 encroaching encroach VBG cord-009571-mygj2nd4 88 4 on on IN cord-009571-mygj2nd4 88 5 the the DT cord-009571-mygj2nd4 88 6 spinal spinal JJ cord-009571-mygj2nd4 88 7 canal canal NN cord-009571-mygj2nd4 88 8 in in IN cord-009571-mygj2nd4 88 9 14 14 CD cord-009571-mygj2nd4 88 10 patients patient NNS cord-009571-mygj2nd4 88 11 . . . cord-009571-mygj2nd4 89 1 Three three CD cord-009571-mygj2nd4 89 2 had have VBD cord-009571-mygj2nd4 89 3 a a DT cord-009571-mygj2nd4 89 4 history history NN cord-009571-mygj2nd4 89 5 of of IN cord-009571-mygj2nd4 89 6 pseudointermittent pseudointermittent NN cord-009571-mygj2nd4 89 7 claudication claudication NN cord-009571-mygj2nd4 89 8 . . . cord-009571-mygj2nd4 90 1 Lumbar lumbar NN cord-009571-mygj2nd4 90 2 x x NNS cord-009571-mygj2nd4 90 3 - - NNS cord-009571-mygj2nd4 90 4 rays ray NNS cord-009571-mygj2nd4 90 5 supported support VBD cord-009571-mygj2nd4 90 6 a a DT cord-009571-mygj2nd4 90 7 diagnosis diagnosis NN cord-009571-mygj2nd4 90 8 of of IN cord-009571-mygj2nd4 90 9 Paget Paget NNP cord-009571-mygj2nd4 90 10 's 's POS cord-009571-mygj2nd4 90 11 disease disease NN cord-009571-mygj2nd4 90 12 at at IN cord-009571-mygj2nd4 90 13 the the DT cord-009571-mygj2nd4 90 14 involved involved JJ cord-009571-mygj2nd4 90 15 site site NN cord-009571-mygj2nd4 90 16 in in IN cord-009571-mygj2nd4 90 17 6 6 CD cord-009571-mygj2nd4 90 18 . . . cord-009571-mygj2nd4 91 1 2 2 LS cord-009571-mygj2nd4 91 2 . . . cord-009571-mygj2nd4 92 1 Lateral lateral JJ cord-009571-mygj2nd4 92 2 recess recess NN cord-009571-mygj2nd4 92 3 syndrome syndrome NN cord-009571-mygj2nd4 92 4 : : : cord-009571-mygj2nd4 92 5 spondylotic spondylotic NNP cord-009571-mygj2nd4 92 6 osteophytes osteophyte NNS cord-009571-mygj2nd4 92 7 encroaching encroach VBG cord-009571-mygj2nd4 92 8 on on IN cord-009571-mygj2nd4 92 9 the the DT cord-009571-mygj2nd4 92 10 intervertebral intervertebral JJ cord-009571-mygj2nd4 92 11 foramina foramen NNS cord-009571-mygj2nd4 92 12 in in IN cord-009571-mygj2nd4 92 13 9 9 CD cord-009571-mygj2nd4 92 14 patients patient NNS cord-009571-mygj2nd4 92 15 . . . cord-009571-mygj2nd4 93 1 All all DT cord-009571-mygj2nd4 93 2 had have VBD cord-009571-mygj2nd4 93 3 sclerotogenous sclerotogenous JJ cord-009571-mygj2nd4 93 4 pain pain NN cord-009571-mygj2nd4 93 5 ( ( -LRB- cord-009571-mygj2nd4 93 6 nonspecific nonspecific JJ cord-009571-mygj2nd4 93 7 pain pain NN cord-009571-mygj2nd4 93 8 referred refer VBN cord-009571-mygj2nd4 93 9 to to IN cord-009571-mygj2nd4 93 10 the the DT cord-009571-mygj2nd4 93 11 buttocks buttock NNS cord-009571-mygj2nd4 93 12 , , , cord-009571-mygj2nd4 93 13 groin groin NN cord-009571-mygj2nd4 93 14 , , , cord-009571-mygj2nd4 93 15 and/or and/or CC cord-009571-mygj2nd4 93 16 thighs thigh NNS cord-009571-mygj2nd4 93 17 ) ) -RRB- cord-009571-mygj2nd4 93 18 . . . cord-009571-mygj2nd4 94 1 Lumbar lumbar NN cord-009571-mygj2nd4 94 2 x x NNS cord-009571-mygj2nd4 94 3 - - NNS cord-009571-mygj2nd4 94 4 rays ray NNS cord-009571-mygj2nd4 94 5 supported support VBD cord-009571-mygj2nd4 94 6 a a DT cord-009571-mygj2nd4 94 7 diagnosis diagnosis NN cord-009571-mygj2nd4 94 8 of of IN cord-009571-mygj2nd4 94 9 Paget Paget NNP cord-009571-mygj2nd4 94 10 's 's POS cord-009571-mygj2nd4 94 11 disease disease NN cord-009571-mygj2nd4 94 12 at at IN cord-009571-mygj2nd4 94 13 the the DT cord-009571-mygj2nd4 94 14 involved involved JJ cord-009571-mygj2nd4 94 15 site site NN cord-009571-mygj2nd4 94 16 in in IN cord-009571-mygj2nd4 94 17 4 4 CD cord-009571-mygj2nd4 94 18 . . . cord-009571-mygj2nd4 95 1 3 3 LS cord-009571-mygj2nd4 95 2 . . . cord-009571-mygj2nd4 96 1 Pagetic pagetic JJ cord-009571-mygj2nd4 96 2 pain pain NN cord-009571-mygj2nd4 96 3 : : : cord-009571-mygj2nd4 96 4 increased increase VBN cord-009571-mygj2nd4 96 5 thickness thickness NN cord-009571-mygj2nd4 96 6 of of IN cord-009571-mygj2nd4 96 7 the the DT cord-009571-mygj2nd4 96 8 laminae laminae NNP cord-009571-mygj2nd4 96 9 , , , cord-009571-mygj2nd4 96 10 pedicles pedicle NNS cord-009571-mygj2nd4 96 11 , , , cord-009571-mygj2nd4 96 12 or or CC cord-009571-mygj2nd4 96 13 bodies body NNS cord-009571-mygj2nd4 96 14 of of IN cord-009571-mygj2nd4 96 15 the the DT cord-009571-mygj2nd4 96 16 vertebrae vertebrae NN cord-009571-mygj2nd4 96 17 secondary secondary JJ cord-009571-mygj2nd4 96 18 to to IN cord-009571-mygj2nd4 96 19 Paget Paget NNP cord-009571-mygj2nd4 96 20 's 's POS cord-009571-mygj2nd4 96 21 disease disease NN cord-009571-mygj2nd4 96 22 in in IN cord-009571-mygj2nd4 96 23 3 3 CD cord-009571-mygj2nd4 96 24 subjects subject NNS cord-009571-mygj2nd4 96 25 without without IN cord-009571-mygj2nd4 96 26 alteration alteration NN cord-009571-mygj2nd4 96 27 of of IN cord-009571-mygj2nd4 96 28 the the DT cord-009571-mygj2nd4 96 29 spinal spinal JJ cord-009571-mygj2nd4 96 30 canal canal NN cord-009571-mygj2nd4 96 31 . . . cord-009571-mygj2nd4 97 1 4 4 LS cord-009571-mygj2nd4 97 2 . . . cord-009571-mygj2nd4 98 1 Spondylotic spondylotic JJ cord-009571-mygj2nd4 98 2 changes change NNS cord-009571-mygj2nd4 98 3 of of IN cord-009571-mygj2nd4 98 4 articular articular JJ cord-009571-mygj2nd4 98 5 facets facet NNS cord-009571-mygj2nd4 98 6 without without IN cord-009571-mygj2nd4 98 7 stenosis stenosis NN cord-009571-mygj2nd4 98 8 or or CC cord-009571-mygj2nd4 98 9 lateral lateral JJ cord-009571-mygj2nd4 98 10 recess recess NN cord-009571-mygj2nd4 98 11 in in IN cord-009571-mygj2nd4 98 12 6 6 CD cord-009571-mygj2nd4 98 13 ; ; SYM cord-009571-mygj2nd4 98 14 5 5 CD cord-009571-mygj2nd4 98 15 had have VBD cord-009571-mygj2nd4 98 16 adjacent adjacent JJ cord-009571-mygj2nd4 98 17 pagetic pagetic JJ cord-009571-mygj2nd4 98 18 changes change NNS cord-009571-mygj2nd4 98 19 . . . cord-009571-mygj2nd4 99 1 In in IN cord-009571-mygj2nd4 99 2 the the DT cord-009571-mygj2nd4 99 3 assessment assessment NN cord-009571-mygj2nd4 99 4 of of IN cord-009571-mygj2nd4 99 5 back back JJ cord-009571-mygj2nd4 99 6 pain pain NN cord-009571-mygj2nd4 99 7 , , , cord-009571-mygj2nd4 99 8 axial axial JJ cord-009571-mygj2nd4 99 9 tomography tomography NN cord-009571-mygj2nd4 99 10 proved prove VBD cord-009571-mygj2nd4 99 11 to to TO cord-009571-mygj2nd4 99 12 be be VB cord-009571-mygj2nd4 99 13 a a DT cord-009571-mygj2nd4 99 14 useful useful JJ cord-009571-mygj2nd4 99 15 tool tool NN cord-009571-mygj2nd4 99 16 in in IN cord-009571-mygj2nd4 99 17 defining define VBG cord-009571-mygj2nd4 99 18 anatomic anatomic JJ cord-009571-mygj2nd4 99 19 spinal spinal JJ cord-009571-mygj2nd4 99 20 lesions lesion NNS cord-009571-mygj2nd4 99 21 that that WDT cord-009571-mygj2nd4 99 22 were be VBD cord-009571-mygj2nd4 99 23 not not RB cord-009571-mygj2nd4 99 24 appreciated appreciate VBN cord-009571-mygj2nd4 99 25 by by IN cord-009571-mygj2nd4 99 26 routine routine JJ cord-009571-mygj2nd4 99 27 x x NN cord-009571-mygj2nd4 99 28 - - NN cord-009571-mygj2nd4 99 29 ray ray NN cord-009571-mygj2nd4 99 30 techniques technique NNS cord-009571-mygj2nd4 99 31 . . . cord-009571-mygj2nd4 100 1 The the DT cord-009571-mygj2nd4 100 2 methods method NNS cord-009571-mygj2nd4 100 3 were be VBD cord-009571-mygj2nd4 100 4 particularly particularly RB cord-009571-mygj2nd4 100 5 helpful helpful JJ cord-009571-mygj2nd4 100 6 in in IN cord-009571-mygj2nd4 100 7 outlining outline VBG cord-009571-mygj2nd4 100 8 the the DT cord-009571-mygj2nd4 100 9 zygapophyseal zygapophyseal JJ cord-009571-mygj2nd4 100 10 articulation articulation NN cord-009571-mygj2nd4 100 11 for for IN cord-009571-mygj2nd4 100 12 definition definition NN cord-009571-mygj2nd4 100 13 of of IN cord-009571-mygj2nd4 100 14 radiographic radiographic JJ cord-009571-mygj2nd4 100 15 joint joint JJ cord-009571-mygj2nd4 100 16 space space NN cord-009571-mygj2nd4 100 17 and and CC cord-009571-mygj2nd4 100 18 hypertrophic hypertrophic JJ cord-009571-mygj2nd4 100 19 changes change NNS cord-009571-mygj2nd4 100 20 . . . cord-009571-mygj2nd4 101 1 Neural neural JJ cord-009571-mygj2nd4 101 2 entrapment entrapment NN cord-009571-mygj2nd4 101 3 by by IN cord-009571-mygj2nd4 101 4 bone bone NN cord-009571-mygj2nd4 101 5 due due IN cord-009571-mygj2nd4 101 6 to to IN cord-009571-mygj2nd4 101 7 hy hy NNP cord-009571-mygj2nd4 101 8 - - HYPH cord-009571-mygj2nd4 101 9 pertrophic pertrophic JJ cord-009571-mygj2nd4 101 10 changes change NNS cord-009571-mygj2nd4 101 11 was be VBD cord-009571-mygj2nd4 101 12 similarly similarly RB cord-009571-mygj2nd4 101 13 defined define VBN cord-009571-mygj2nd4 101 14 . . . cord-009571-mygj2nd4 102 1 In in IN cord-009571-mygj2nd4 102 2 several several JJ cord-009571-mygj2nd4 102 3 cases case NNS cord-009571-mygj2nd4 102 4 the the DT cord-009571-mygj2nd4 102 5 procedure procedure NN cord-009571-mygj2nd4 102 6 obviated obviate VBD cord-009571-mygj2nd4 102 7 the the DT cord-009571-mygj2nd4 102 8 need need NN cord-009571-mygj2nd4 102 9 for for IN cord-009571-mygj2nd4 102 10 myelography myelography NN cord-009571-mygj2nd4 102 11 . . . cord-009571-mygj2nd4 103 1 In in IN cord-009571-mygj2nd4 103 2 Paget Paget NNP cord-009571-mygj2nd4 103 3 's 's POS cord-009571-mygj2nd4 103 4 disease disease NN cord-009571-mygj2nd4 103 5 , , , cord-009571-mygj2nd4 103 6 determining determine VBG cord-009571-mygj2nd4 103 7 the the DT cord-009571-mygj2nd4 103 8 degree degree NN cord-009571-mygj2nd4 103 9 of of IN cord-009571-mygj2nd4 103 10 spondj4osis spondj4osis NNP cord-009571-mygj2nd4 103 11 could could MD cord-009571-mygj2nd4 103 12 guide guide VB cord-009571-mygj2nd4 103 13 therapy therapy NN cord-009571-mygj2nd4 103 14 since since IN cord-009571-mygj2nd4 103 15 it -PRON- PRP cord-009571-mygj2nd4 103 16 would would MD cord-009571-mygj2nd4 103 17 predict predict VB cord-009571-mygj2nd4 103 18 those those DT cord-009571-mygj2nd4 103 19 that that WDT cord-009571-mygj2nd4 103 20 might may MD cord-009571-mygj2nd4 103 21 be be VB cord-009571-mygj2nd4 103 22 expected expect VBN cord-009571-mygj2nd4 103 23 to to TO cord-009571-mygj2nd4 103 24 respond respond VB cord-009571-mygj2nd4 103 25 to to IN cord-009571-mygj2nd4 103 26 suppressive suppressive JJ cord-009571-mygj2nd4 103 27 therapy therapy NN cord-009571-mygj2nd4 103 28 of of IN cord-009571-mygj2nd4 103 29 their -PRON- PRP$ cord-009571-mygj2nd4 103 30 Paget Paget NNP cord-009571-mygj2nd4 103 31 's 's POS cord-009571-mygj2nd4 103 32 disease disease NN cord-009571-mygj2nd4 103 33 . . . cord-009571-mygj2nd4 104 1 HLA HLA NNP cord-009571-mygj2nd4 104 2 - - HYPH cord-009571-mygj2nd4 104 3 B27 B27 NNP cord-009571-mygj2nd4 104 4 is be VBZ cord-009571-mygj2nd4 104 5 a a DT cord-009571-mygj2nd4 104 6 potent potent JJ cord-009571-mygj2nd4 104 7 genetic genetic JJ cord-009571-mygj2nd4 104 8 marker marker NN cord-009571-mygj2nd4 104 9 for for IN cord-009571-mygj2nd4 104 10 ankylosing ankylose VBG cord-009571-mygj2nd4 104 11 spondylitis spondylitis NN cord-009571-mygj2nd4 104 12 ( ( -LRB- cord-009571-mygj2nd4 104 13 AS as RB cord-009571-mygj2nd4 104 14 ) ) -RRB- cord-009571-mygj2nd4 104 15 , , , cord-009571-mygj2nd4 104 16 Reiter Reiter NNP cord-009571-mygj2nd4 104 17 's 's POS cord-009571-mygj2nd4 104 18 syndrome syndrome NN cord-009571-mygj2nd4 104 19 ( ( -LRB- cord-009571-mygj2nd4 104 20 RS RS NNP cord-009571-mygj2nd4 104 21 ) ) -RRB- cord-009571-mygj2nd4 104 22 , , , cord-009571-mygj2nd4 104 23 and and CC cord-009571-mygj2nd4 104 24 other other JJ cord-009571-mygj2nd4 104 25 spondylitic spondylitic JJ cord-009571-mygj2nd4 104 26 variants variant NNS cord-009571-mygj2nd4 104 27 . . . cord-009571-mygj2nd4 105 1 This this DT cord-009571-mygj2nd4 105 2 cell cell NN cord-009571-mygj2nd4 105 3 surface surface NN cord-009571-mygj2nd4 105 4 antigen antigen NN cord-009571-mygj2nd4 105 5 is be VBZ cord-009571-mygj2nd4 105 6 determined determine VBN cord-009571-mygj2nd4 105 7 by by IN cord-009571-mygj2nd4 105 8 the the DT cord-009571-mygj2nd4 105 9 HLA HLA NNP cord-009571-mygj2nd4 105 10 - - HYPH cord-009571-mygj2nd4 105 11 B b NN cord-009571-mygj2nd4 105 12 locus locus NN cord-009571-mygj2nd4 105 13 , , , cord-009571-mygj2nd4 105 14 one one CD cord-009571-mygj2nd4 105 15 of of IN cord-009571-mygj2nd4 105 16 a a DT cord-009571-mygj2nd4 105 17 linear linear JJ cord-009571-mygj2nd4 105 18 array array NN cord-009571-mygj2nd4 105 19 of of IN cord-009571-mygj2nd4 105 20 genes gene NNS cord-009571-mygj2nd4 105 21 clustered cluster VBN cord-009571-mygj2nd4 105 22 on on IN cord-009571-mygj2nd4 105 23 the the DT cord-009571-mygj2nd4 105 24 sixth sixth JJ cord-009571-mygj2nd4 105 25 chromosome chromosome NN cord-009571-mygj2nd4 105 26 . . . cord-009571-mygj2nd4 106 1 Whether whether IN cord-009571-mygj2nd4 106 2 HLA HLA NNP cord-009571-mygj2nd4 106 3 - - HYPH cord-009571-mygj2nd4 106 4 B B NNP cord-009571-mygj2nd4 106 5 is be VBZ cord-009571-mygj2nd4 106 6 the the DT cord-009571-mygj2nd4 106 7 disease disease NN cord-009571-mygj2nd4 106 8 - - HYPH cord-009571-mygj2nd4 106 9 conferring confer VBG cord-009571-mygj2nd4 106 10 gene gene NN cord-009571-mygj2nd4 106 11 or or CC cord-009571-mygj2nd4 106 12 only only RB cord-009571-mygj2nd4 106 13 linked link VBN cord-009571-mygj2nd4 106 14 to to IN cord-009571-mygj2nd4 106 15 another another DT cord-009571-mygj2nd4 106 16 nearby nearby JJ cord-009571-mygj2nd4 106 17 gene gene NN cord-009571-mygj2nd4 106 18 remains remain VBZ cord-009571-mygj2nd4 106 19 unclear unclear JJ cord-009571-mygj2nd4 106 20 . . . cord-009571-mygj2nd4 107 1 Studies study NNS cord-009571-mygj2nd4 107 2 of of IN cord-009571-mygj2nd4 107 3 HLA HLA NNP cord-009571-mygj2nd4 107 4 - - HYPH cord-009571-mygj2nd4 107 5 D D NNP cord-009571-mygj2nd4 107 6 on on IN cord-009571-mygj2nd4 107 7 one one CD cord-009571-mygj2nd4 107 8 side side NN cord-009571-mygj2nd4 107 9 of of IN cord-009571-mygj2nd4 107 10 HLA HLA NNP cord-009571-mygj2nd4 107 11 - - HYPH cord-009571-mygj2nd4 107 12 B B NNP cord-009571-mygj2nd4 107 13 ( ( -LRB- cord-009571-mygj2nd4 107 14 1 1 CD cord-009571-mygj2nd4 107 15 map map NN cord-009571-mygj2nd4 107 16 unit unit NN cord-009571-mygj2nd4 107 17 ) ) -RRB- cord-009571-mygj2nd4 107 18 have have VBP cord-009571-mygj2nd4 107 19 shown show VBN cord-009571-mygj2nd4 107 20 no no DT cord-009571-mygj2nd4 107 21 associations association NNS cord-009571-mygj2nd4 107 22 with with IN cord-009571-mygj2nd4 107 23 AS AS NNP cord-009571-mygj2nd4 107 24 or or CC cord-009571-mygj2nd4 107 25 B27 B27 NNP cord-009571-mygj2nd4 107 26 . . . cord-009571-mygj2nd4 108 1 The the DT cord-009571-mygj2nd4 108 2 HLA HLA NNP cord-009571-mygj2nd4 108 3 - - HYPH cord-009571-mygj2nd4 108 4 C C NNP cord-009571-mygj2nd4 108 5 locus locus NN cord-009571-mygj2nd4 108 6 lines line NNS cord-009571-mygj2nd4 108 7 0.2 0.2 CD cord-009571-mygj2nd4 108 8 map map NN cord-009571-mygj2nd4 108 9 units unit NNS cord-009571-mygj2nd4 108 10 to to IN cord-009571-mygj2nd4 108 11 the the DT cord-009571-mygj2nd4 108 12 opposite opposite JJ cord-009571-mygj2nd4 108 13 side side NN cord-009571-mygj2nd4 108 14 of of IN cord-009571-mygj2nd4 108 15 HLA HLA NNP cord-009571-mygj2nd4 108 16 - - HYPH cord-009571-mygj2nd4 108 17 B. B. NNP cord-009571-mygj2nd4 109 1 It -PRON- PRP cord-009571-mygj2nd4 109 2 was be VBD cord-009571-mygj2nd4 109 3 our -PRON- PRP$ cord-009571-mygj2nd4 109 4 purpose purpose NN cord-009571-mygj2nd4 109 5 to to TO cord-009571-mygj2nd4 109 6 study study VB cord-009571-mygj2nd4 109 7 C C NNP cord-009571-mygj2nd4 109 8 locus locus NN cord-009571-mygj2nd4 109 9 antigens antigen NNS cord-009571-mygj2nd4 109 10 in in IN cord-009571-mygj2nd4 109 11 B27 B27 JJS cord-009571-mygj2nd4 109 12 positive positive JJ cord-009571-mygj2nd4 109 13 and and CC cord-009571-mygj2nd4 109 14 negative negative JJ cord-009571-mygj2nd4 109 15 patients patient NNS cord-009571-mygj2nd4 109 16 in in IN cord-009571-mygj2nd4 109 17 order order NN cord-009571-mygj2nd4 109 18 to to TO cord-009571-mygj2nd4 109 19 more more RBR cord-009571-mygj2nd4 109 20 precisely precisely RB cord-009571-mygj2nd4 109 21 localize localize VB cord-009571-mygj2nd4 109 22 the the DT cord-009571-mygj2nd4 109 23 disease disease NN cord-009571-mygj2nd4 109 24 promoting promote VBG cord-009571-mygj2nd4 109 25 gene gene NN cord-009571-mygj2nd4 109 26 . . . cord-009571-mygj2nd4 110 1 Eighty eighty CD cord-009571-mygj2nd4 110 2 - - HYPH cord-009571-mygj2nd4 110 3 eight eight CD cord-009571-mygj2nd4 110 4 patients patient NNS cord-009571-mygj2nd4 110 5 ( ( -LRB- cord-009571-mygj2nd4 110 6 30 30 CD cord-009571-mygj2nd4 110 7 AS AS NNP cord-009571-mygj2nd4 110 8 , , , cord-009571-mygj2nd4 110 9 37 37 CD cord-009571-mygj2nd4 110 10 RS rs NN cord-009571-mygj2nd4 110 11 , , , cord-009571-mygj2nd4 110 12 9 9 CD cord-009571-mygj2nd4 110 13 sacroiliitis sacroiliitis NN cord-009571-mygj2nd4 110 14 , , , cord-009571-mygj2nd4 110 15 9 9 CD cord-009571-mygj2nd4 110 16 psoriatic psoriatic JJ cord-009571-mygj2nd4 110 17 spondylitis spondylitis NN cord-009571-mygj2nd4 110 18 , , , cord-009571-mygj2nd4 110 19 and and CC cord-009571-mygj2nd4 110 20 3 3 CD cord-009571-mygj2nd4 110 21 colitic colitic JJ cord-009571-mygj2nd4 110 22 spondylitis spondylitis NN cord-009571-mygj2nd4 110 23 ) ) -RRB- cord-009571-mygj2nd4 110 24 were be VBD cord-009571-mygj2nd4 110 25 HLA HLA NNP cord-009571-mygj2nd4 110 26 Cwl Cwl NNP cord-009571-mygj2nd4 110 27 , , , cord-009571-mygj2nd4 110 28 P p NN cord-009571-mygj2nd4 110 29 < < XX cord-009571-mygj2nd4 110 30 0.025 0.025 CD cord-009571-mygj2nd4 110 31 for for IN cord-009571-mygj2nd4 110 32 Cw2 cw2 NN cord-009571-mygj2nd4 110 33 , , , cord-009571-mygj2nd4 110 34 and and CC cord-009571-mygj2nd4 110 35 P p NN cord-009571-mygj2nd4 110 36 < < XX cord-009571-mygj2nd4 110 37 0.005 0.005 CD cord-009571-mygj2nd4 110 38 for for IN cord-009571-mygj2nd4 110 39 either either DT cord-009571-mygj2nd4 110 40 Cwl Cwl NNP cord-009571-mygj2nd4 110 41 and and CC cord-009571-mygj2nd4 110 42 Cw2 cw2 NN cord-009571-mygj2nd4 110 43 . . . cord-009571-mygj2nd4 111 1 Similar similar JJ cord-009571-mygj2nd4 111 2 significant significant JJ cord-009571-mygj2nd4 111 3 differences difference NNS cord-009571-mygj2nd4 111 4 were be VBD cord-009571-mygj2nd4 111 5 found find VBN cord-009571-mygj2nd4 111 6 when when WRB cord-009571-mygj2nd4 111 7 both both DT cord-009571-mygj2nd4 111 8 the the DT cord-009571-mygj2nd4 111 9 B27 B27 NNPS cord-009571-mygj2nd4 111 10 + + SYM cord-009571-mygj2nd4 111 11 patients patient NNS cord-009571-mygj2nd4 111 12 and and CC cord-009571-mygj2nd4 111 13 the the DT cord-009571-mygj2nd4 111 14 B27 B27 NNP cord-009571-mygj2nd4 111 15 + + PRP$ cord-009571-mygj2nd4 111 16 controls control NNS cord-009571-mygj2nd4 111 17 were be VBD cord-009571-mygj2nd4 111 18 compared compare VBN cord-009571-mygj2nd4 111 19 with with IN cord-009571-mygj2nd4 111 20 the the DT cord-009571-mygj2nd4 111 21 matched match VBN cord-009571-mygj2nd4 111 22 controls control NNS cord-009571-mygj2nd4 111 23 . . . cord-009571-mygj2nd4 112 1 There there EX cord-009571-mygj2nd4 112 2 were be VBD cord-009571-mygj2nd4 112 3 no no DT cord-009571-mygj2nd4 112 4 significant significant JJ cord-009571-mygj2nd4 112 5 differences difference NNS cord-009571-mygj2nd4 112 6 noted note VBN cord-009571-mygj2nd4 112 7 between between IN cord-009571-mygj2nd4 112 8 B27 B27 NNP cord-009571-mygj2nd4 112 9 + + SYM cord-009571-mygj2nd4 112 10 patients patient NNS cord-009571-mygj2nd4 112 11 and and CC cord-009571-mygj2nd4 112 12 B27+controls b27+control NNS cord-009571-mygj2nd4 112 13 or or CC cord-009571-mygj2nd4 112 14 between between IN cord-009571-mygj2nd4 112 15 B27patients B27patients NNP cord-009571-mygj2nd4 112 16 and and CC cord-009571-mygj2nd4 112 17 matched match VBN cord-009571-mygj2nd4 112 18 controls control NNS cord-009571-mygj2nd4 112 19 . . . cord-009571-mygj2nd4 113 1 The the DT cord-009571-mygj2nd4 113 2 occurrence occurrence NN cord-009571-mygj2nd4 113 3 of of IN cord-009571-mygj2nd4 113 4 Cw3 cw3 NN cord-009571-mygj2nd4 113 5 and and CC cord-009571-mygj2nd4 113 6 Cw4 Cw4 NNP cord-009571-mygj2nd4 113 7 was be VBD cord-009571-mygj2nd4 113 8 similar similar JJ cord-009571-mygj2nd4 113 9 within within IN cord-009571-mygj2nd4 113 10 all all DT cord-009571-mygj2nd4 113 11 groups group NNS cord-009571-mygj2nd4 113 12 . . . cord-009571-mygj2nd4 114 1 Thus thus RB cord-009571-mygj2nd4 114 2 , , , cord-009571-mygj2nd4 114 3 these these DT cord-009571-mygj2nd4 114 4 data datum NNS cord-009571-mygj2nd4 114 5 confirm confirm VBP cord-009571-mygj2nd4 114 6 strong strong JJ cord-009571-mygj2nd4 114 7 linkage linkage NN cord-009571-mygj2nd4 114 8 disequilibrium disequilibrium NN cord-009571-mygj2nd4 114 9 between between IN cord-009571-mygj2nd4 114 10 B27 B27 NNP cord-009571-mygj2nd4 114 11 , , , cord-009571-mygj2nd4 114 12 Cwl Cwl NNP cord-009571-mygj2nd4 114 13 , , , cord-009571-mygj2nd4 114 14 and and CC cord-009571-mygj2nd4 114 15 Cw2 cw2 NN cord-009571-mygj2nd4 114 16 which which WDT cord-009571-mygj2nd4 114 17 does do VBZ cord-009571-mygj2nd4 114 18 not not RB cord-009571-mygj2nd4 114 19 relate relate VB cord-009571-mygj2nd4 114 20 to to IN cord-009571-mygj2nd4 114 21 disease disease NN cord-009571-mygj2nd4 114 22 . . . cord-009571-mygj2nd4 115 1 Most most RBS cord-009571-mygj2nd4 115 2 importantly importantly RB cord-009571-mygj2nd4 115 3 , , , cord-009571-mygj2nd4 115 4 the the DT cord-009571-mygj2nd4 115 5 absence absence NN cord-009571-mygj2nd4 115 6 of of IN cord-009571-mygj2nd4 115 7 Cwl Cwl NNP cord-009571-mygj2nd4 115 8 and and CC cord-009571-mygj2nd4 115 9 Cw2 cw2 NN cord-009571-mygj2nd4 115 10 in in IN cord-009571-mygj2nd4 115 11 B27patients B27patients NNP cord-009571-mygj2nd4 115 12 provides provide VBZ cord-009571-mygj2nd4 115 13 further further JJ cord-009571-mygj2nd4 115 14 evidence evidence NN cord-009571-mygj2nd4 115 15 that that IN cord-009571-mygj2nd4 115 16 recombination recombination NN cord-009571-mygj2nd4 115 17 between between IN cord-009571-mygj2nd4 115 18 B b NN cord-009571-mygj2nd4 115 19 and and CC cord-009571-mygj2nd4 115 20 C C NNP cord-009571-mygj2nd4 115 21 loci locus NNS cord-009571-mygj2nd4 115 22 is be VBZ cord-009571-mygj2nd4 115 23 unlikely unlikely JJ cord-009571-mygj2nd4 115 24 , , , cord-009571-mygj2nd4 115 25 and and CC cord-009571-mygj2nd4 115 26 that that IN cord-009571-mygj2nd4 115 27 disease disease NN cord-009571-mygj2nd4 115 28 susceptibility susceptibility NN cord-009571-mygj2nd4 115 29 is be VBZ cord-009571-mygj2nd4 115 30 intimately intimately RB cord-009571-mygj2nd4 115 31 related relate VBN cord-009571-mygj2nd4 115 32 to to IN cord-009571-mygj2nd4 115 33 or or CC cord-009571-mygj2nd4 115 34 inseparable inseparable JJ cord-009571-mygj2nd4 115 35 from from IN cord-009571-mygj2nd4 115 36 the the DT cord-009571-mygj2nd4 115 37 B B NNP cord-009571-mygj2nd4 115 38 locus locus NN cord-009571-mygj2nd4 115 39 . . . cord-009571-mygj2nd4 116 1 Control Control NNP cord-009571-mygj2nd4 116 2 Groups Groups NNPS cord-009571-mygj2nd4 116 3 ( ( -LRB- cord-009571-mygj2nd4 116 4 N=68 N=68 NNP cord-009571-mygj2nd4 116 5 ) ) -RRB- cord-009571-mygj2nd4 116 6 , , , cord-009571-mygj2nd4 116 7 % % NN cord-009571-mygj2nd4 116 8 ( ( -LRB- cord-009571-mygj2nd4 116 9 N=20 N=20 NNP cord-009571-mygj2nd4 116 10 ) ) -RRB- cord-009571-mygj2nd4 116 11 , , , cord-009571-mygj2nd4 116 12 % % NN cord-009571-mygj2nd4 116 13 ( ( -LRB- cord-009571-mygj2nd4 116 14 N=64 N=64 NNP cord-009571-mygj2nd4 116 15 ) ) -RRB- cord-009571-mygj2nd4 116 16 , , , cord-009571-mygj2nd4 116 17 % % NN cord-009571-mygj2nd4 116 18 ( ( -LRB- cord-009571-mygj2nd4 116 19 N=88),% N=88),% NNP cord-009571-mygj2nd4 116 20 typed type VBD cord-009571-mygj2nd4 116 21 for for IN cord-009571-mygj2nd4 116 22 A A NNP cord-009571-mygj2nd4 116 23 , , , cord-009571-mygj2nd4 116 24 B b NN cord-009571-mygj2nd4 116 25 , , , cord-009571-mygj2nd4 116 26 and and CC cord-009571-mygj2nd4 116 27 the the DT cord-009571-mygj2nd4 116 28 C C NNP cord-009571-mygj2nd4 116 29 locus locus NN cord-009571-mygj2nd4 116 30 antigens antigen NNS cord-009571-mygj2nd4 116 31 , , , cord-009571-mygj2nd4 116 32 Cwl Cwl NNP cord-009571-mygj2nd4 116 33 , , , cord-009571-mygj2nd4 116 34 Cw2 cw2 NN cord-009571-mygj2nd4 116 35 , , , cord-009571-mygj2nd4 116 36 Cw3 cw3 NN cord-009571-mygj2nd4 116 37 , , , cord-009571-mygj2nd4 116 38 and and CC cord-009571-mygj2nd4 116 39 Cw4 cw4 NN cord-009571-mygj2nd4 116 40 . . . cord-009571-mygj2nd4 117 1 In in IN cord-009571-mygj2nd4 117 2 addition addition NN cord-009571-mygj2nd4 117 3 , , , cord-009571-mygj2nd4 117 4 88 88 CD cord-009571-mygj2nd4 117 5 age age NN cord-009571-mygj2nd4 117 6 , , , cord-009571-mygj2nd4 117 7 sex sex NN cord-009571-mygj2nd4 117 8 , , , cord-009571-mygj2nd4 117 9 and and CC cord-009571-mygj2nd4 117 10 race race NN cord-009571-mygj2nd4 117 11 matched match VBD cord-009571-mygj2nd4 117 12 normal normal JJ cord-009571-mygj2nd4 117 13 controls control NNS cord-009571-mygj2nd4 117 14 and and CC cord-009571-mygj2nd4 117 15 64 64 CD cord-009571-mygj2nd4 117 16 B27 B27 JJS cord-009571-mygj2nd4 117 17 positive positive JJ cord-009571-mygj2nd4 117 18 normal normal JJ cord-009571-mygj2nd4 117 19 controls control NNS cord-009571-mygj2nd4 117 20 were be VBD cord-009571-mygj2nd4 117 21 similarly similarly RB cord-009571-mygj2nd4 117 22 studied study VBN cord-009571-mygj2nd4 117 23 and and CC cord-009571-mygj2nd4 117 24 compared compare VBN cord-009571-mygj2nd4 117 25 to to IN cord-009571-mygj2nd4 117 26 those those DT cord-009571-mygj2nd4 117 27 with with IN cord-009571-mygj2nd4 117 28 disease disease NN cord-009571-mygj2nd4 117 29 . . . cord-009571-mygj2nd4 118 1 HLA HLA NNP cord-009571-mygj2nd4 118 2 - - HYPH cord-009571-mygj2nd4 118 3 B27 B27 NNP cord-009571-mygj2nd4 118 4 was be VBD cord-009571-mygj2nd4 118 5 present present JJ cord-009571-mygj2nd4 118 6 Results result NNS cord-009571-mygj2nd4 118 7 of of IN cord-009571-mygj2nd4 118 8 C C NNP cord-009571-mygj2nd4 118 9 locus locus NN cord-009571-mygj2nd4 118 10 typing typing NN cord-009571-mygj2nd4 118 11 are be VBP cord-009571-mygj2nd4 118 12 shown show VBN cord-009571-mygj2nd4 118 13 in in IN cord-009571-mygj2nd4 118 14 the the DT cord-009571-mygj2nd4 118 15 table table NN cord-009571-mygj2nd4 118 16 . . . cord-009571-mygj2nd4 118 17 _SP cord-009571-mygj2nd4 119 1 An an DT cord-009571-mygj2nd4 119 2 immunofluorescent immunofluorescent NN cord-009571-mygj2nd4 119 3 complement complement NN cord-009571-mygj2nd4 119 4 fixation fixation NN cord-009571-mygj2nd4 119 5 ( ( -LRB- cord-009571-mygj2nd4 119 6 IFCF IFCF NNP cord-009571-mygj2nd4 119 7 ) ) -RRB- cord-009571-mygj2nd4 119 8 test test NN cord-009571-mygj2nd4 119 9 was be VBD cord-009571-mygj2nd4 119 10 used use VBN cord-009571-mygj2nd4 119 11 to to TO cord-009571-mygj2nd4 119 12 determine determine VB cord-009571-mygj2nd4 119 13 if if IN cord-009571-mygj2nd4 119 14 nuclear nuclear JJ cord-009571-mygj2nd4 119 15 antigen antigen NN cord-009571-mygj2nd4 119 16 - - HYPH cord-009571-mygj2nd4 119 17 antibody antibody NN cord-009571-mygj2nd4 119 18 complexes complex NNS cord-009571-mygj2nd4 119 19 of of IN cord-009571-mygj2nd4 119 20 different different JJ cord-009571-mygj2nd4 119 21 specificities specificity NNS cord-009571-mygj2nd4 119 22 possessed possess VBD cord-009571-mygj2nd4 119 23 different different JJ cord-009571-mygj2nd4 119 24 capacities capacity NNS cord-009571-mygj2nd4 119 25 to to TO cord-009571-mygj2nd4 119 26 fix fix VB cord-009571-mygj2nd4 119 27 complement complement NN cord-009571-mygj2nd4 119 28 . . . cord-009571-mygj2nd4 120 1 Sera Sera NNP cord-009571-mygj2nd4 120 2 from from IN cord-009571-mygj2nd4 120 3 patients patient NNS cord-009571-mygj2nd4 120 4 with with IN cord-009571-mygj2nd4 120 5 rheumatic rheumatic JJ cord-009571-mygj2nd4 120 6 diseases disease NNS cord-009571-mygj2nd4 120 7 were be VBD cord-009571-mygj2nd4 120 8 specially specially RB cord-009571-mygj2nd4 120 9 selected select VBN cord-009571-mygj2nd4 120 10 and and CC cord-009571-mygj2nd4 120 11 demonstrated demonstrate VBD cord-009571-mygj2nd4 120 12 to to TO cord-009571-mygj2nd4 120 13 contain contain VB cord-009571-mygj2nd4 120 14 only only RB cord-009571-mygj2nd4 120 15 antibodies antibody NNS cord-009571-mygj2nd4 120 16 to to IN cord-009571-mygj2nd4 120 17 Sm sm NN cord-009571-mygj2nd4 120 18 antigen antigen NN cord-009571-mygj2nd4 120 19 ( ( -LRB- cord-009571-mygj2nd4 120 20 5 5 CD cord-009571-mygj2nd4 120 21 patients patient NNS cord-009571-mygj2nd4 120 22 ) ) -RRB- cord-009571-mygj2nd4 120 23 , , , cord-009571-mygj2nd4 120 24 nuclear nuclear JJ cord-009571-mygj2nd4 120 25 RNP RNP NNP cord-009571-mygj2nd4 120 26 ( ( -LRB- cord-009571-mygj2nd4 120 27 7 7 CD cord-009571-mygj2nd4 120 28 ) ) -RRB- cord-009571-mygj2nd4 120 29 , , , cord-009571-mygj2nd4 120 30 SS SS NNP cord-009571-mygj2nd4 120 31 - - HYPH cord-009571-mygj2nd4 120 32 B B NNP cord-009571-mygj2nd4 120 33 antigen antigen NN cord-009571-mygj2nd4 120 34 ( ( -LRB- cord-009571-mygj2nd4 120 35 3 3 CD cord-009571-mygj2nd4 120 36 ) ) -RRB- cord-009571-mygj2nd4 120 37 , , , cord-009571-mygj2nd4 120 38 or or CC cord-009571-mygj2nd4 120 39 nuclear nuclear JJ cord-009571-mygj2nd4 120 40 histones histone NNS cord-009571-mygj2nd4 120 41 ( ( -LRB- cord-009571-mygj2nd4 120 42 7 7 CD cord-009571-mygj2nd4 120 43 ) ) -RRB- cord-009571-mygj2nd4 120 44 . . . cord-009571-mygj2nd4 121 1 Column column NN cord-009571-mygj2nd4 121 2 chromatography chromatography NN cord-009571-mygj2nd4 121 3 isolated isolate VBN cord-009571-mygj2nd4 121 4 - - HYPH cord-009571-mygj2nd4 121 5 IgG igg NN cord-009571-mygj2nd4 121 6 from from IN cord-009571-mygj2nd4 121 7 these these DT cord-009571-mygj2nd4 121 8 sera sera NNP cord-009571-mygj2nd4 121 9 were be VBD cord-009571-mygj2nd4 121 10 reacted react VBN cord-009571-mygj2nd4 121 11 with with IN cord-009571-mygj2nd4 121 12 sections section NNS cord-009571-mygj2nd4 121 13 of of IN cord-009571-mygj2nd4 121 14 mouse mouse NN cord-009571-mygj2nd4 121 15 liver liver NN cord-009571-mygj2nd4 121 16 to to TO cord-009571-mygj2nd4 121 17 form form VB cord-009571-mygj2nd4 121 18 nuclear nuclear JJ cord-009571-mygj2nd4 121 19 Ag Ag NNP cord-009571-mygj2nd4 121 20 - - HYPH cord-009571-mygj2nd4 121 21 Ab Ab NNP cord-009571-mygj2nd4 121 22 complexes complex NNS cord-009571-mygj2nd4 121 23 of of IN cord-009571-mygj2nd4 121 24 the the DT cord-009571-mygj2nd4 121 25 different different JJ cord-009571-mygj2nd4 121 26 specificities specificity NNS cord-009571-mygj2nd4 121 27 described describe VBN cord-009571-mygj2nd4 121 28 above above RB cord-009571-mygj2nd4 121 29 . . . cord-009571-mygj2nd4 122 1 Binding bind VBG cord-009571-mygj2nd4 122 2 of of IN cord-009571-mygj2nd4 122 3 complement complement JJ cord-009571-mygj2nd4 122 4 components component NNS cord-009571-mygj2nd4 122 5 to to IN cord-009571-mygj2nd4 122 6 the the DT cord-009571-mygj2nd4 122 7 nuclear nuclear JJ cord-009571-mygj2nd4 122 8 Ag Ag NNP cord-009571-mygj2nd4 122 9 - - HYPH cord-009571-mygj2nd4 122 10 Ab Ab NNP cord-009571-mygj2nd4 122 11 complexes complex NNS cord-009571-mygj2nd4 122 12 was be VBD cord-009571-mygj2nd4 122 13 determined determine VBN cord-009571-mygj2nd4 122 14 after after IN cord-009571-mygj2nd4 122 15 washing wash VBG cord-009571-mygj2nd4 122 16 away away RB cord-009571-mygj2nd4 122 17 excess excess JJ cord-009571-mygj2nd4 122 18 serum serum NN cord-009571-mygj2nd4 122 19 and and CC cord-009571-mygj2nd4 122 20 incubating incubate VBG cord-009571-mygj2nd4 122 21 with with IN cord-009571-mygj2nd4 122 22 3 3 CD cord-009571-mygj2nd4 122 23 different different JJ cord-009571-mygj2nd4 122 24 sources source NNS cord-009571-mygj2nd4 122 25 of of IN cord-009571-mygj2nd4 122 26 complement complement NN cord-009571-mygj2nd4 122 27 : : : cord-009571-mygj2nd4 122 28 1 1 LS cord-009571-mygj2nd4 122 29 ) ) -RRB- cord-009571-mygj2nd4 122 30 normal normal JJ cord-009571-mygj2nd4 122 31 human human JJ cord-009571-mygj2nd4 122 32 serum serum NN cord-009571-mygj2nd4 122 33 ( ( -LRB- cord-009571-mygj2nd4 122 34 NHS NHS NNP cord-009571-mygj2nd4 122 35 ) ) -RRB- cord-009571-mygj2nd4 122 36 ; ; : cord-009571-mygj2nd4 123 1 2 2 LS cord-009571-mygj2nd4 123 2 ) ) -RRB- cord-009571-mygj2nd4 123 3 NHS NHS NNP cord-009571-mygj2nd4 123 4 - - HYPH cord-009571-mygj2nd4 123 5 EGTA EGTA NNP cord-009571-mygj2nd4 123 6 Mg Mg NNP cord-009571-mygj2nd4 123 7 , , , cord-009571-mygj2nd4 123 8 conditions condition NNS cord-009571-mygj2nd4 123 9 which which WDT cord-009571-mygj2nd4 123 10 are be VBP cord-009571-mygj2nd4 123 11 known know VBN cord-009571-mygj2nd4 123 12 to to TO cord-009571-mygj2nd4 123 13 block block VB cord-009571-mygj2nd4 123 14 activation activation NN cord-009571-mygj2nd4 123 15 of of IN cord-009571-mygj2nd4 123 16 the the DT cord-009571-mygj2nd4 123 17 classic classic JJ cord-009571-mygj2nd4 123 18 pathway pathway NN cord-009571-mygj2nd4 123 19 ; ; : cord-009571-mygj2nd4 123 20 3 3 LS cord-009571-mygj2nd4 123 21 ) ) -RRB- cord-009571-mygj2nd4 123 22 immunologically immunologically RB cord-009571-mygj2nd4 123 23 Clq Clq NNP cord-009571-mygj2nd4 123 24 - - HYPH cord-009571-mygj2nd4 123 25 depleted deplete VBN cord-009571-mygj2nd4 123 26 sera sera NNP cord-009571-mygj2nd4 123 27 in in IN cord-009571-mygj2nd4 123 28 which which WDT cord-009571-mygj2nd4 123 29 other other JJ cord-009571-mygj2nd4 123 30 complement complement NN cord-009571-mygj2nd4 123 31 proteins protein NNS cord-009571-mygj2nd4 123 32 were be VBD cord-009571-mygj2nd4 123 33 demonstrated demonstrate VBN cord-009571-mygj2nd4 123 34 to to TO cord-009571-mygj2nd4 123 35 be be VB cord-009571-mygj2nd4 123 36 90 90 CD cord-009571-mygj2nd4 123 37 % % NN cord-009571-mygj2nd4 123 38 hemolytically hemolytically RB cord-009571-mygj2nd4 123 39 active active JJ cord-009571-mygj2nd4 123 40 . . . cord-009571-mygj2nd4 124 1 Fixation fixation NN cord-009571-mygj2nd4 124 2 of of IN cord-009571-mygj2nd4 124 3 complement complement NN cord-009571-mygj2nd4 124 4 was be VBD cord-009571-mygj2nd4 124 5 determined determine VBN cord-009571-mygj2nd4 124 6 by by IN cord-009571-mygj2nd4 124 7 using use VBG cord-009571-mygj2nd4 124 8 fluorescein fluorescein NN cord-009571-mygj2nd4 124 9 - - HYPH cord-009571-mygj2nd4 124 10 conjugated conjugate VBN cord-009571-mygj2nd4 124 11 antiserum antiserum NN cord-009571-mygj2nd4 124 12 to to IN cord-009571-mygj2nd4 124 13 Clq Clq NNP cord-009571-mygj2nd4 124 14 , , , cord-009571-mygj2nd4 124 15 C4 C4 NNP cord-009571-mygj2nd4 124 16 , , , cord-009571-mygj2nd4 124 17 properdin properdin NN cord-009571-mygj2nd4 124 18 , , , cord-009571-mygj2nd4 124 19 factor factor NN cord-009571-mygj2nd4 124 20 B b NN cord-009571-mygj2nd4 124 21 , , , cord-009571-mygj2nd4 124 22 C3 C3 NNP cord-009571-mygj2nd4 124 23 , , , cord-009571-mygj2nd4 124 24 C6 C6 NNP cord-009571-mygj2nd4 124 25 , , , cord-009571-mygj2nd4 124 26 and and CC cord-009571-mygj2nd4 124 27 C9 C9 NNP cord-009571-mygj2nd4 124 28 . . . cord-009571-mygj2nd4 125 1 All all DT cord-009571-mygj2nd4 125 2 sera sera FW cord-009571-mygj2nd4 125 3 with with IN cord-009571-mygj2nd4 125 4 antibodies antibody NNS cord-009571-mygj2nd4 125 5 to to IN cord-009571-mygj2nd4 125 6 Sm sm NN cord-009571-mygj2nd4 125 7 antigen antigen NN cord-009571-mygj2nd4 125 8 , , , cord-009571-mygj2nd4 125 9 nuclear nuclear JJ cord-009571-mygj2nd4 125 10 RNP RNP NNP cord-009571-mygj2nd4 125 11 , , , cord-009571-mygj2nd4 125 12 and and CC cord-009571-mygj2nd4 125 13 SS SS NNP cord-009571-mygj2nd4 125 14 - - HYPH cord-009571-mygj2nd4 125 15 B B NNP cord-009571-mygj2nd4 125 16 nuclear nuclear JJ cord-009571-mygj2nd4 125 17 antigens antigen NNS cord-009571-mygj2nd4 125 18 showed show VBD cord-009571-mygj2nd4 125 19 fixation fixation NN cord-009571-mygj2nd4 125 20 of of IN cord-009571-mygj2nd4 125 21 all all DT cord-009571-mygj2nd4 125 22 complement complement NN cord-009571-mygj2nd4 125 23 proteins protein NNS cord-009571-mygj2nd4 125 24 when when WRB cord-009571-mygj2nd4 125 25 NHS NHS NNP cord-009571-mygj2nd4 125 26 was be VBD cord-009571-mygj2nd4 125 27 used use VBN cord-009571-mygj2nd4 125 28 as as IN cord-009571-mygj2nd4 125 29 the the DT cord-009571-mygj2nd4 125 30 source source NN cord-009571-mygj2nd4 125 31 of of IN cord-009571-mygj2nd4 125 32 complement complement NN cord-009571-mygj2nd4 125 33 . . . cord-009571-mygj2nd4 126 1 When when WRB cord-009571-mygj2nd4 126 2 the the DT cord-009571-mygj2nd4 126 3 source source NN cord-009571-mygj2nd4 126 4 of of IN cord-009571-mygj2nd4 126 5 complement complement NN cord-009571-mygj2nd4 126 6 was be VBD cord-009571-mygj2nd4 126 7 EGTA- EGTA- NNS cord-009571-mygj2nd4 127 1 Mg Mg NNP cord-009571-mygj2nd4 127 2 or or CC cord-009571-mygj2nd4 127 3 Clq Clq NNP cord-009571-mygj2nd4 127 4 - - HYPH cord-009571-mygj2nd4 127 5 depleted deplete VBN cord-009571-mygj2nd4 127 6 serum serum NN cord-009571-mygj2nd4 127 7 , , , cord-009571-mygj2nd4 127 8 Clq Clq NNP cord-009571-mygj2nd4 127 9 and and CC cord-009571-mygj2nd4 127 10 C4 C4 NNP cord-009571-mygj2nd4 127 11 were be VBD cord-009571-mygj2nd4 127 12 negative negative JJ cord-009571-mygj2nd4 127 13 by by IN cord-009571-mygj2nd4 127 14 IFCF IFCF NNP cord-009571-mygj2nd4 127 15 . . . cord-009571-mygj2nd4 128 1 However however RB cord-009571-mygj2nd4 128 2 , , , cord-009571-mygj2nd4 128 3 complement complement NN cord-009571-mygj2nd4 128 4 proteins protein NNS cord-009571-mygj2nd4 128 5 properdin properdin NN cord-009571-mygj2nd4 128 6 , , , cord-009571-mygj2nd4 128 7 factor factor NN cord-009571-mygj2nd4 128 8 B b NN cord-009571-mygj2nd4 128 9 , , , cord-009571-mygj2nd4 128 10 C3 C3 NNP cord-009571-mygj2nd4 128 11 , , , cord-009571-mygj2nd4 128 12 C6 C6 NNP cord-009571-mygj2nd4 128 13 , , , cord-009571-mygj2nd4 128 14 and and CC cord-009571-mygj2nd4 128 15 C9 C9 NNP cord-009571-mygj2nd4 128 16 were be VBD cord-009571-mygj2nd4 128 17 positive positive JJ cord-009571-mygj2nd4 128 18 , , , cord-009571-mygj2nd4 128 19 showing show VBG cord-009571-mygj2nd4 128 20 that that IN cord-009571-mygj2nd4 128 21 these these DT cord-009571-mygj2nd4 128 22 nuclear nuclear JJ cord-009571-mygj2nd4 128 23 antigen antigen NN cord-009571-mygj2nd4 128 24 - - HYPH cord-009571-mygj2nd4 128 25 antibody antibody NN cord-009571-mygj2nd4 128 26 complexes complex NNS cord-009571-mygj2nd4 128 27 were be VBD cord-009571-mygj2nd4 128 28 able able JJ cord-009571-mygj2nd4 128 29 to to TO cord-009571-mygj2nd4 128 30 fix fix VB cord-009571-mygj2nd4 128 31 complement complement NN cord-009571-mygj2nd4 128 32 proteins protein NNS cord-009571-mygj2nd4 128 33 of of IN cord-009571-mygj2nd4 128 34 the the DT cord-009571-mygj2nd4 128 35 alternative alternative JJ cord-009571-mygj2nd4 128 36 pathway pathway NN cord-009571-mygj2nd4 128 37 , , , cord-009571-mygj2nd4 128 38 without without IN cord-009571-mygj2nd4 128 39 concomitant concomitant JJ cord-009571-mygj2nd4 128 40 fixation fixation NN cord-009571-mygj2nd4 128 41 of of IN cord-009571-mygj2nd4 128 42 the the DT cord-009571-mygj2nd4 128 43 classic classic JJ cord-009571-mygj2nd4 128 44 pathway pathway NN cord-009571-mygj2nd4 128 45 . . . cord-009571-mygj2nd4 129 1 The the DT cord-009571-mygj2nd4 129 2 7 7 CD cord-009571-mygj2nd4 129 3 sera sera NNP cord-009571-mygj2nd4 129 4 with with IN cord-009571-mygj2nd4 129 5 antibodies antibody NNS cord-009571-mygj2nd4 129 6 to to IN cord-009571-mygj2nd4 129 7 nuclear nuclear JJ cord-009571-mygj2nd4 129 8 histones histone NNS cord-009571-mygj2nd4 129 9 did do VBD cord-009571-mygj2nd4 129 10 not not RB cord-009571-mygj2nd4 129 11 fix fix VB cord-009571-mygj2nd4 129 12 any any DT cord-009571-mygj2nd4 129 13 complement complement JJ cord-009571-mygj2nd4 129 14 component component NN cord-009571-mygj2nd4 129 15 of of IN cord-009571-mygj2nd4 129 16 either either CC cord-009571-mygj2nd4 129 17 the the DT cord-009571-mygj2nd4 129 18 classic classic JJ cord-009571-mygj2nd4 129 19 or or CC cord-009571-mygj2nd4 129 20 alternative alternative JJ cord-009571-mygj2nd4 129 21 pathways pathway NNS cord-009571-mygj2nd4 129 22 . . . cord-009571-mygj2nd4 130 1 These these DT cord-009571-mygj2nd4 130 2 studies study NNS cord-009571-mygj2nd4 130 3 demonstrate demonstrate VBP cord-009571-mygj2nd4 130 4 two two CD cord-009571-mygj2nd4 130 5 important important JJ cord-009571-mygj2nd4 130 6 findings finding NNS cord-009571-mygj2nd4 130 7 . . . cord-009571-mygj2nd4 131 1 bodies body NNS cord-009571-mygj2nd4 131 2 of of IN cord-009571-mygj2nd4 131 3 certain certain JJ cord-009571-mygj2nd4 131 4 specificities specificity NNS cord-009571-mygj2nd4 131 5 to to TO cord-009571-mygj2nd4 131 6 activate activate VB cord-009571-mygj2nd4 131 7 complement complement NN cord-009571-mygj2nd4 131 8 may may MD cord-009571-mygj2nd4 131 9 have have VB cord-009571-mygj2nd4 131 10 Certain certain JJ cord-009571-mygj2nd4 131 11 nuclear nuclear JJ cord-009571-mygj2nd4 131 12 Ag Ag NNP cord-009571-mygj2nd4 131 13 - - HYPH cord-009571-mygj2nd4 131 14 Ab Ab NNP cord-009571-mygj2nd4 131 15 complexes complex NNS cord-009571-mygj2nd4 131 16 are be VBP cord-009571-mygj2nd4 131 17 capable capable JJ cord-009571-mygj2nd4 131 18 of of IN cord-009571-mygj2nd4 131 19 activating activate VBG cord-009571-mygj2nd4 131 20 the the DT cord-009571-mygj2nd4 131 21 relationship relationship NN cord-009571-mygj2nd4 131 22 to to IN cord-009571-mygj2nd4 131 23 their -PRON- PRP$ cord-009571-mygj2nd4 131 24 capacities capacity NNS cord-009571-mygj2nd4 131 25 to to TO cord-009571-mygj2nd4 131 26 cause cause VB cord-009571-mygj2nd4 131 27 tissue tissue NN cord-009571-mygj2nd4 131 28 damage damage NN cord-009571-mygj2nd4 131 29 by by IN cord-009571-mygj2nd4 131 30 realternative realternative JJ cord-009571-mygj2nd4 131 31 complement complement JJ cord-009571-mygj2nd4 131 32 pathway pathway NN cord-009571-mygj2nd4 131 33 , , , cord-009571-mygj2nd4 131 34 independent independent JJ cord-009571-mygj2nd4 131 35 of of IN cord-009571-mygj2nd4 131 36 classic classic JJ cord-009571-mygj2nd4 131 37 path path NN cord-009571-mygj2nd4 131 38 - - HYPH cord-009571-mygj2nd4 131 39 lease lease NN cord-009571-mygj2nd4 131 40 of of IN cord-009571-mygj2nd4 131 41 inflammatory inflammatory JJ cord-009571-mygj2nd4 131 42 peptides peptide NNS cord-009571-mygj2nd4 131 43 mediated mediate VBN cord-009571-mygj2nd4 131 44 by by IN cord-009571-mygj2nd4 131 45 complement complement NN cord-009571-mygj2nd4 131 46 actiway actiway NNP cord-009571-mygj2nd4 131 47 activation activation NN cord-009571-mygj2nd4 131 48 . . . cord-009571-mygj2nd4 132 1 Reactions reaction NNS cord-009571-mygj2nd4 132 2 between between IN cord-009571-mygj2nd4 132 3 nuclear nuclear JJ cord-009571-mygj2nd4 132 4 histones histone NNS cord-009571-mygj2nd4 132 5 and and CC cord-009571-mygj2nd4 132 6 anti anti JJ cord-009571-mygj2nd4 132 7 - - NN cord-009571-mygj2nd4 132 8 vation vation NN cord-009571-mygj2nd4 132 9 . . . cord-009571-mygj2nd4 133 1 Our -PRON- PRP$ cord-009571-mygj2nd4 133 2 results result NNS cord-009571-mygj2nd4 133 3 may may MD cord-009571-mygj2nd4 133 4 explain explain VB cord-009571-mygj2nd4 133 5 why why WRB cord-009571-mygj2nd4 133 6 drug drug NN cord-009571-mygj2nd4 133 7 - - HYPH cord-009571-mygj2nd4 133 8 induced induce VBN cord-009571-mygj2nd4 133 9 lupus lupus NN cord-009571-mygj2nd4 133 10 erbody erbody NNP cord-009571-mygj2nd4 133 11 , , , cord-009571-mygj2nd4 133 12 as as IN cord-009571-mygj2nd4 133 13 demonstrated demonstrate VBN cord-009571-mygj2nd4 133 14 by by IN cord-009571-mygj2nd4 133 15 the the DT cord-009571-mygj2nd4 133 16 immunofluorescent immunofluorescent NN cord-009571-mygj2nd4 133 17 technique technique NN cord-009571-mygj2nd4 133 18 , , , cord-009571-mygj2nd4 133 19 ythematosus ythematosus NNP cord-009571-mygj2nd4 133 20 , , , cord-009571-mygj2nd4 133 21 characterized characterize VBN cord-009571-mygj2nd4 133 22 by by IN cord-009571-mygj2nd4 133 23 anti anti JJ cord-009571-mygj2nd4 133 24 - - JJ cord-009571-mygj2nd4 133 25 histone histone JJ cord-009571-mygj2nd4 133 26 Ab ab NN cord-009571-mygj2nd4 133 27 , , , cord-009571-mygj2nd4 133 28 is be VBZ cord-009571-mygj2nd4 133 29 rarely rarely RB cord-009571-mygj2nd4 133 30 appear appear VBP cord-009571-mygj2nd4 133 31 not not RB cord-009571-mygj2nd4 133 32 to to TO cord-009571-mygj2nd4 133 33 be be VB cord-009571-mygj2nd4 133 34 complement complement NN cord-009571-mygj2nd4 133 35 - - HYPH cord-009571-mygj2nd4 133 36 fixing fix VBG cord-009571-mygj2nd4 133 37 reactions reaction NNS cord-009571-mygj2nd4 133 38 or or CC cord-009571-mygj2nd4 133 39 at at IN cord-009571-mygj2nd4 133 40 least least JJS cord-009571-mygj2nd4 133 41 not not RB cord-009571-mygj2nd4 133 42 associated associate VBN cord-009571-mygj2nd4 133 43 with with IN cord-009571-mygj2nd4 133 44 inflammatory inflammatory JJ cord-009571-mygj2nd4 133 45 kidney kidney NN cord-009571-mygj2nd4 133 46 disease disease NN cord-009571-mygj2nd4 133 47 . . . cord-009571-mygj2nd4 134 1 detectable detectable JJ cord-009571-mygj2nd4 134 2 by by IN cord-009571-mygj2nd4 134 3 this this DT cord-009571-mygj2nd4 134 4 technique technique NN cord-009571-mygj2nd4 134 5 . . . cord-009571-mygj2nd4 135 1 The the DT cord-009571-mygj2nd4 135 2 capacity capacity NN cord-009571-mygj2nd4 135 3 of of IN cord-009571-mygj2nd4 135 4 antinuclear antinuclear JJ cord-009571-mygj2nd4 135 5 anti- anti- JJ cord-009571-mygj2nd4 135 6 It -PRON- PRP cord-009571-mygj2nd4 135 7 has have VBZ cord-009571-mygj2nd4 135 8 been be VBN cord-009571-mygj2nd4 135 9 suggested suggest VBN cord-009571-mygj2nd4 135 10 that that IN cord-009571-mygj2nd4 135 11 renal renal JJ cord-009571-mygj2nd4 135 12 involvement involvement NN cord-009571-mygj2nd4 135 13 in in IN cord-009571-mygj2nd4 135 14 SLE SLE NNP cord-009571-mygj2nd4 135 15 patients patient NNS cord-009571-mygj2nd4 135 16 may may MD cord-009571-mygj2nd4 135 17 depend depend VB cord-009571-mygj2nd4 135 18 upon upon IN cord-009571-mygj2nd4 135 19 qualitative qualitative JJ cord-009571-mygj2nd4 135 20 immunochemical immunochemical JJ cord-009571-mygj2nd4 135 21 characteristics characteristic NNS cord-009571-mygj2nd4 135 22 of of IN cord-009571-mygj2nd4 135 23 antibodies antibody NNS cord-009571-mygj2nd4 135 24 to to IN cord-009571-mygj2nd4 135 25 DNA dna NN cord-009571-mygj2nd4 135 26 , , , cord-009571-mygj2nd4 135 27 e.g. e.g. RB cord-009571-mygj2nd4 135 28 , , , cord-009571-mygj2nd4 135 29 precipitating precipitate VBG cord-009571-mygj2nd4 135 30 ability ability NN cord-009571-mygj2nd4 135 31 , , , cord-009571-mygj2nd4 135 32 affinity affinity NN cord-009571-mygj2nd4 135 33 , , , cord-009571-mygj2nd4 135 34 Ig Ig NNP cord-009571-mygj2nd4 135 35 class class NN cord-009571-mygj2nd4 135 36 or or CC cord-009571-mygj2nd4 135 37 subclass subclass NN cord-009571-mygj2nd4 135 38 , , , cord-009571-mygj2nd4 135 39 and and CC cord-009571-mygj2nd4 135 40 complement complement VB cord-009571-mygj2nd4 135 41 fixing fix VBG cord-009571-mygj2nd4 135 42 ( ( -LRB- cord-009571-mygj2nd4 135 43 CF cf NN cord-009571-mygj2nd4 135 44 ) ) -RRB- cord-009571-mygj2nd4 135 45 capacity capacity NN cord-009571-mygj2nd4 135 46 . . . cord-009571-mygj2nd4 136 1 We -PRON- PRP cord-009571-mygj2nd4 136 2 used use VBD cord-009571-mygj2nd4 136 3 the the DT cord-009571-mygj2nd4 136 4 immunofluorescent immunofluorescent NN cord-009571-mygj2nd4 137 1 Crithidia Crithidia NNP cord-009571-mygj2nd4 137 2 Luciliae Luciliae NNP cord-009571-mygj2nd4 137 3 method method NN cord-009571-mygj2nd4 137 4 [ [ -LRB- cord-009571-mygj2nd4 137 5 a a DT cord-009571-mygj2nd4 137 6 - - HYPH cord-009571-mygj2nd4 137 7 DNA(CL dna(cl NN cord-009571-mygj2nd4 137 8 ) ) -RRB- cord-009571-mygj2nd4 137 9 ] ] -RRB- cord-009571-mygj2nd4 138 1 to to TO cord-009571-mygj2nd4 138 2 delineate delineate VB cord-009571-mygj2nd4 138 3 some some DT cord-009571-mygj2nd4 138 4 of of IN cord-009571-mygj2nd4 138 5 these these DT cord-009571-mygj2nd4 138 6 characteristics characteristic NNS cord-009571-mygj2nd4 138 7 in in IN cord-009571-mygj2nd4 138 8 sera sera NNP cord-009571-mygj2nd4 138 9 from from IN cord-009571-mygj2nd4 138 10 35 35 CD cord-009571-mygj2nd4 138 11 patients patient NNS cord-009571-mygj2nd4 138 12 with with IN cord-009571-mygj2nd4 138 13 active active JJ cord-009571-mygj2nd4 138 14 SLE SLE NNP cord-009571-mygj2nd4 138 15 . . . cord-009571-mygj2nd4 139 1 Using use VBG cord-009571-mygj2nd4 139 2 FITClabeled fitclabeled JJ cord-009571-mygj2nd4 139 3 polyspecific polyspecific FW cord-009571-mygj2nd4 139 4 antiserum antiserum NN cord-009571-mygj2nd4 139 5 to to IN cord-009571-mygj2nd4 139 6 IgG IgG NNP cord-009571-mygj2nd4 139 7 , , , cord-009571-mygj2nd4 139 8 IgA IgA NNP cord-009571-mygj2nd4 139 9 , , , cord-009571-mygj2nd4 139 10 and and CC cord-009571-mygj2nd4 139 11 IgM IgM NNP cord-009571-mygj2nd4 139 12 , , , cord-009571-mygj2nd4 139 13 a a DT cord-009571-mygj2nd4 139 14 - - : cord-009571-mygj2nd4 139 15 DNA(CL DNA(CL NNP cord-009571-mygj2nd4 139 16 ) ) -RRB- cord-009571-mygj2nd4 139 17 was be VBD cord-009571-mygj2nd4 139 18 found find VBN cord-009571-mygj2nd4 139 19 in in IN cord-009571-mygj2nd4 139 20 17 17 CD cord-009571-mygj2nd4 139 21 of of IN cord-009571-mygj2nd4 139 22 18 18 CD cord-009571-mygj2nd4 139 23 patients patient NNS cord-009571-mygj2nd4 139 24 with with IN cord-009571-mygj2nd4 139 25 active active JJ cord-009571-mygj2nd4 139 26 lupus lupus NN cord-009571-mygj2nd4 139 27 nephritis nephritis NN cord-009571-mygj2nd4 139 28 ( ( -LRB- cord-009571-mygj2nd4 139 29 Gp Gp NNP cord-009571-mygj2nd4 139 30 - - HYPH cord-009571-mygj2nd4 139 31 I I NNP cord-009571-mygj2nd4 139 32 ) ) -RRB- cord-009571-mygj2nd4 139 33 and and CC cord-009571-mygj2nd4 139 34 11 11 CD cord-009571-mygj2nd4 139 35 of of IN cord-009571-mygj2nd4 139 36 17 17 CD cord-009571-mygj2nd4 139 37 patients patient NNS cord-009571-mygj2nd4 139 38 with with IN cord-009571-mygj2nd4 139 39 lupus lupus NN cord-009571-mygj2nd4 139 40 activity activity NN cord-009571-mygj2nd4 139 41 without without IN cord-009571-mygj2nd4 139 42 nephritis nephritis NN cord-009571-mygj2nd4 139 43 . . . cord-009571-mygj2nd4 140 1 Median median JJ cord-009571-mygj2nd4 140 2 titer titer NN cord-009571-mygj2nd4 140 3 in in IN cord-009571-mygj2nd4 140 4 Gp Gp NNP cord-009571-mygj2nd4 140 5 - - HYPH cord-009571-mygj2nd4 140 6 I -PRON- PRP cord-009571-mygj2nd4 140 7 was be VBD cord-009571-mygj2nd4 140 8 1 1 CD cord-009571-mygj2nd4 140 9 : : SYM cord-009571-mygj2nd4 140 10 160 160 CD cord-009571-mygj2nd4 140 11 and and CC cord-009571-mygj2nd4 140 12 in in IN cord-009571-mygj2nd4 140 13 Gp Gp NNP cord-009571-mygj2nd4 140 14 - - HYPH cord-009571-mygj2nd4 140 15 I1 i1 NN cord-009571-mygj2nd4 140 16 1 1 CD cord-009571-mygj2nd4 140 17 : : SYM cord-009571-mygj2nd4 140 18 40 40 CD cord-009571-mygj2nd4 140 19 ; ; : cord-009571-mygj2nd4 140 20 the the DT cord-009571-mygj2nd4 140 21 difference difference NN cord-009571-mygj2nd4 140 22 in in IN cord-009571-mygj2nd4 140 23 titers titer NNS cord-009571-mygj2nd4 140 24 between between IN cord-009571-mygj2nd4 140 25 these these DT cord-009571-mygj2nd4 140 26 groups group NNS cord-009571-mygj2nd4 140 27 was be VBD cord-009571-mygj2nd4 140 28 significant significant JJ cord-009571-mygj2nd4 140 29 ( ( -LRB- cord-009571-mygj2nd4 140 30 P p NN cord-009571-mygj2nd4 140 31 < < XX cord-009571-mygj2nd4 140 32 0.005 0.005 CD cord-009571-mygj2nd4 140 33 ) ) -RRB- cord-009571-mygj2nd4 140 34 . . . cord-009571-mygj2nd4 141 1 C C NNP cord-009571-mygj2nd4 141 2 F F NNP cord-009571-mygj2nd4 141 3 antibodies antibody NNS cord-009571-mygj2nd4 141 4 to to IN cord-009571-mygj2nd4 141 5 DNA DNA NNP cord-009571-mygj2nd4 141 6 were be VBD cord-009571-mygj2nd4 141 7 found find VBN cord-009571-mygj2nd4 141 8 in in IN cord-009571-mygj2nd4 141 9 13 13 CD cord-009571-mygj2nd4 141 10 patients patient NNS cord-009571-mygj2nd4 141 11 in in IN cord-009571-mygj2nd4 141 12 G g NN cord-009571-mygj2nd4 141 13 p p NN cord-009571-mygj2nd4 141 14 I i NN cord-009571-mygj2nd4 141 15 and and CC cord-009571-mygj2nd4 141 16 5 5 CD cord-009571-mygj2nd4 141 17 patients patient NNS cord-009571-mygj2nd4 141 18 in in IN cord-009571-mygj2nd4 141 19 Gp Gp NNP cord-009571-mygj2nd4 141 20 - - HYPH cord-009571-mygj2nd4 141 21 I1 i1 NN cord-009571-mygj2nd4 141 22 using use VBG cord-009571-mygj2nd4 141 23 a a DT cord-009571-mygj2nd4 141 24 double double JJ cord-009571-mygj2nd4 141 25 sandwich sandwich NN cord-009571-mygj2nd4 141 26 technique technique NN cord-009571-mygj2nd4 141 27 to to TO cord-009571-mygj2nd4 141 28 detect detect VB cord-009571-mygj2nd4 141 29 C3 C3 NNP cord-009571-mygj2nd4 141 30 binding binding NN cord-009571-mygj2nd4 141 31 . . . cord-009571-mygj2nd4 142 1 When when WRB cord-009571-mygj2nd4 142 2 titer titer NN cord-009571-mygj2nd4 142 3 of of IN cord-009571-mygj2nd4 142 4 C C NNP cord-009571-mygj2nd4 142 5 F F NNP cord-009571-mygj2nd4 142 6 activity activity NN cord-009571-mygj2nd4 142 7 was be VBD cord-009571-mygj2nd4 142 8 compared compare VBN cord-009571-mygj2nd4 142 9 with with IN cord-009571-mygj2nd4 142 10 a a DT cord-009571-mygj2nd4 142 11 - - HYPH cord-009571-mygj2nd4 142 12 DNA(CL dna(cl CD cord-009571-mygj2nd4 142 13 ) ) -RRB- cord-009571-mygj2nd4 142 14 titer titer NN cord-009571-mygj2nd4 142 15 , , , cord-009571-mygj2nd4 142 16 a a DT cord-009571-mygj2nd4 142 17 strong strong JJ cord-009571-mygj2nd4 142 18 correlation correlation NN cord-009571-mygj2nd4 142 19 was be VBD cord-009571-mygj2nd4 142 20 found find VBN cord-009571-mygj2nd4 143 1 ( ( -LRB- cord-009571-mygj2nd4 143 2 r r NN cord-009571-mygj2nd4 143 3 = = SYM cord-009571-mygj2nd4 143 4 0.73 0.73 CD cord-009571-mygj2nd4 143 5 ; ; : cord-009571-mygj2nd4 143 6 P p NN cord-009571-mygj2nd4 143 7 < < XX cord-009571-mygj2nd4 143 8 0.001 0.001 CD cord-009571-mygj2nd4 143 9 ) ) -RRB- cord-009571-mygj2nd4 143 10 . . . cord-009571-mygj2nd4 144 1 IgG IgG NNP cord-009571-mygj2nd4 144 2 , , , cord-009571-mygj2nd4 144 3 IgA IgA NNP cord-009571-mygj2nd4 144 4 , , , cord-009571-mygj2nd4 144 5 and and CC cord-009571-mygj2nd4 144 6 IgM IgM NNP cord-009571-mygj2nd4 144 7 a a DT cord-009571-mygj2nd4 144 8 - - : cord-009571-mygj2nd4 144 9 DNA(CL DNA(CL NNP cord-009571-mygj2nd4 144 10 ) ) -RRB- cord-009571-mygj2nd4 144 11 were be VBD cord-009571-mygj2nd4 144 12 detected detect VBN cord-009571-mygj2nd4 144 13 with with IN cord-009571-mygj2nd4 144 14 high high JJ cord-009571-mygj2nd4 144 15 frequency frequency NN cord-009571-mygj2nd4 144 16 in in IN cord-009571-mygj2nd4 144 17 both both DT cord-009571-mygj2nd4 144 18 groups group NNS cord-009571-mygj2nd4 144 19 . . . cord-009571-mygj2nd4 145 1 In in IN cord-009571-mygj2nd4 145 2 addition addition NN cord-009571-mygj2nd4 145 3 , , , cord-009571-mygj2nd4 145 4 we -PRON- PRP cord-009571-mygj2nd4 145 5 compared compare VBD cord-009571-mygj2nd4 145 6 titers titer NNS cord-009571-mygj2nd4 145 7 of of IN cord-009571-mygj2nd4 145 8 a a DT cord-009571-mygj2nd4 145 9 - - HYPH cord-009571-mygj2nd4 145 10 DNA(CL DNA(CL NNP cord-009571-mygj2nd4 145 11 ) ) -RRB- cord-009571-mygj2nd4 145 12 , , , cord-009571-mygj2nd4 145 13 which which WDT cord-009571-mygj2nd4 145 14 detects detect VBZ cord-009571-mygj2nd4 145 15 antibodies antibody NNS cord-009571-mygj2nd4 145 16 primarily primarily RB cord-009571-mygj2nd4 145 17 directed direct VBN cord-009571-mygj2nd4 145 18 against against IN cord-009571-mygj2nd4 145 19 dsDNA dsdna RB cord-009571-mygj2nd4 145 20 determi determi NN cord-009571-mygj2nd4 145 21 - - HYPH cord-009571-mygj2nd4 145 22 nants nant NNS cord-009571-mygj2nd4 145 23 , , , cord-009571-mygj2nd4 145 24 with with IN cord-009571-mygj2nd4 145 25 DNA dna NN cord-009571-mygj2nd4 145 26 binding binding NN cord-009571-mygj2nd4 145 27 capacity capacity NN cord-009571-mygj2nd4 145 28 detected detect VBN cord-009571-mygj2nd4 145 29 by by IN cord-009571-mygj2nd4 145 30 the the DT cord-009571-mygj2nd4 145 31 millipore millipore NNP cord-009571-mygj2nd4 145 32 filter filter NNP cord-009571-mygj2nd4 145 33 ( ( -LRB- cord-009571-mygj2nd4 145 34 MF MF NNP cord-009571-mygj2nd4 145 35 ) ) -RRB- cord-009571-mygj2nd4 145 36 method method NN cord-009571-mygj2nd4 145 37 of of IN cord-009571-mygj2nd4 145 38 Ginsberg Ginsberg NNP cord-009571-mygj2nd4 145 39 and and CC cord-009571-mygj2nd4 145 40 Keiser Keiser NNP cord-009571-mygj2nd4 145 41 , , , cord-009571-mygj2nd4 145 42 in in IN cord-009571-mygj2nd4 145 43 each each DT cord-009571-mygj2nd4 145 44 of of IN cord-009571-mygj2nd4 145 45 these these DT cord-009571-mygj2nd4 145 46 groups group NNS cord-009571-mygj2nd4 145 47 . . . cord-009571-mygj2nd4 146 1 As as IN cord-009571-mygj2nd4 146 2 antigen antigen NN cord-009571-mygj2nd4 146 3 we -PRON- PRP cord-009571-mygj2nd4 146 4 employed employ VBD cord-009571-mygj2nd4 146 5 1 1 CD cord-009571-mygj2nd4 146 6 * * CD cord-009571-mygj2nd4 146 7 61-labeled 61-labeled CD cord-009571-mygj2nd4 146 8 calf calf NN cord-009571-mygj2nd4 146 9 thymus thymus NN cord-009571-mygj2nd4 146 10 DNA dna NN cord-009571-mygj2nd4 146 11 ( ( -LRB- cord-009571-mygj2nd4 146 12 type type NN cord-009571-mygj2nd4 146 13 I I NNP cord-009571-mygj2nd4 146 14 , , , cord-009571-mygj2nd4 146 15 Sigma Sigma NNP cord-009571-mygj2nd4 146 16 ) ) -RRB- cord-009571-mygj2nd4 146 17 passed pass VBD cord-009571-mygj2nd4 146 18 through through IN cord-009571-mygj2nd4 146 19 an an DT cord-009571-mygj2nd4 146 20 0.45 0.45 CD cord-009571-mygj2nd4 146 21 p p NN cord-009571-mygj2nd4 146 22 , , , cord-009571-mygj2nd4 146 23 type type NN cord-009571-mygj2nd4 146 24 HA HA NNP cord-009571-mygj2nd4 146 25 millipore millipore NNP cord-009571-mygj2nd4 146 26 filter filter NN cord-009571-mygj2nd4 146 27 . . . cord-009571-mygj2nd4 147 1 In in IN cord-009571-mygj2nd4 147 2 contrast contrast NN cord-009571-mygj2nd4 147 3 to to IN cord-009571-mygj2nd4 147 4 the the DT cord-009571-mygj2nd4 147 5 CL CL NNP cord-009571-mygj2nd4 147 6 method method NN cord-009571-mygj2nd4 147 7 , , , cord-009571-mygj2nd4 147 8 levels level NNS cord-009571-mygj2nd4 147 9 of of IN cord-009571-mygj2nd4 147 10 a a DT cord-009571-mygj2nd4 147 11 - - HYPH cord-009571-mygj2nd4 147 12 DNA(MF DNA(MF NNP cord-009571-mygj2nd4 147 13 ) ) -RRB- cord-009571-mygj2nd4 147 14 did do VBD cord-009571-mygj2nd4 147 15 not not RB cord-009571-mygj2nd4 147 16 differ differ VB cord-009571-mygj2nd4 147 17 significantly significantly RB cord-009571-mygj2nd4 147 18 in in IN cord-009571-mygj2nd4 147 19 Gps Gps NNP cord-009571-mygj2nd4 147 20 I I NNP cord-009571-mygj2nd4 147 21 and and CC cord-009571-mygj2nd4 147 22 11 11 CD cord-009571-mygj2nd4 147 23 . . . cord-009571-mygj2nd4 148 1 When when WRB cord-009571-mygj2nd4 148 2 we -PRON- PRP cord-009571-mygj2nd4 148 3 compared compare VBD cord-009571-mygj2nd4 148 4 a a DT cord-009571-mygj2nd4 148 5 - - HYPH cord-009571-mygj2nd4 148 6 DNA(CL dna(cl CD cord-009571-mygj2nd4 148 7 ) ) -RRB- cord-009571-mygj2nd4 148 8 titer titer NN cord-009571-mygj2nd4 148 9 in in IN cord-009571-mygj2nd4 148 10 Gp Gp NNP cord-009571-mygj2nd4 148 11 - - HYPH cord-009571-mygj2nd4 148 12 I I NNP cord-009571-mygj2nd4 148 13 sera sera NNP cord-009571-mygj2nd4 148 14 with with IN cord-009571-mygj2nd4 148 15 quantitative quantitative JJ cord-009571-mygj2nd4 148 16 a a NNP cord-009571-mygj2nd4 148 17 - - HYPH cord-009571-mygj2nd4 148 18 DNA(MF DNA(MF NNP cord-009571-mygj2nd4 148 19 ) ) -RRB- cord-009571-mygj2nd4 148 20 , , , cord-009571-mygj2nd4 148 21 a a DT cord-009571-mygj2nd4 148 22 highly highly RB cord-009571-mygj2nd4 148 23 significant significant JJ cord-009571-mygj2nd4 148 24 correlation correlation NN cord-009571-mygj2nd4 148 25 was be VBD cord-009571-mygj2nd4 148 26 found find VBN cord-009571-mygj2nd4 148 27 ( ( -LRB- cord-009571-mygj2nd4 148 28 r r NN cord-009571-mygj2nd4 148 29 = = SYM cord-009571-mygj2nd4 148 30 0.89 0.89 CD cord-009571-mygj2nd4 148 31 , , , cord-009571-mygj2nd4 148 32 P p NN cord-009571-mygj2nd4 148 33 < < XX cord-009571-mygj2nd4 148 34 0.001 0.001 CD cord-009571-mygj2nd4 148 35 ) ) -RRB- cord-009571-mygj2nd4 148 36 , , , cord-009571-mygj2nd4 148 37 while while IN cord-009571-mygj2nd4 148 38 no no DT cord-009571-mygj2nd4 148 39 correlation correlation NN cord-009571-mygj2nd4 148 40 between between IN cord-009571-mygj2nd4 148 41 these these DT cord-009571-mygj2nd4 148 42 methods method NNS cord-009571-mygj2nd4 148 43 was be VBD cord-009571-mygj2nd4 148 44 evident evident JJ cord-009571-mygj2nd4 148 45 in in IN cord-009571-mygj2nd4 148 46 sera sera NNP cord-009571-mygj2nd4 148 47 from from IN cord-009571-mygj2nd4 148 48 Gp Gp NNP cord-009571-mygj2nd4 148 49 - - HYPH cord-009571-mygj2nd4 148 50 I1 i1 NN cord-009571-mygj2nd4 148 51 patients patient NNS cord-009571-mygj2nd4 148 52 . . . cord-009571-mygj2nd4 149 1 These these DT cord-009571-mygj2nd4 149 2 findings finding NNS cord-009571-mygj2nd4 149 3 suggest suggest VBP cord-009571-mygj2nd4 149 4 that that IN cord-009571-mygj2nd4 149 5 : : : cord-009571-mygj2nd4 149 6 1 1 LS cord-009571-mygj2nd4 149 7 ) ) -RRB- cord-009571-mygj2nd4 149 8 the the DT cord-009571-mygj2nd4 149 9 presence presence NN cord-009571-mygj2nd4 149 10 of of IN cord-009571-mygj2nd4 149 11 high high JJ cord-009571-mygj2nd4 149 12 titered titered JJ cord-009571-mygj2nd4 149 13 a a DT cord-009571-mygj2nd4 149 14 - - HYPH cord-009571-mygj2nd4 149 15 DNA(CL DNA(CL NNP cord-009571-mygj2nd4 149 16 ) ) -RRB- cord-009571-mygj2nd4 149 17 is be VBZ cord-009571-mygj2nd4 149 18 strongly strongly RB cord-009571-mygj2nd4 149 19 correlated correlate VBN cord-009571-mygj2nd4 149 20 with with IN cord-009571-mygj2nd4 149 21 active active JJ cord-009571-mygj2nd4 149 22 renal renal JJ cord-009571-mygj2nd4 149 23 lupus lupus NN cord-009571-mygj2nd4 149 24 ; ; : cord-009571-mygj2nd4 149 25 2 2 LS cord-009571-mygj2nd4 149 26 ) ) -RRB- cord-009571-mygj2nd4 149 27 detection detection NN cord-009571-mygj2nd4 149 28 of of IN cord-009571-mygj2nd4 149 29 C c NN cord-009571-mygj2nd4 149 30 - - HYPH cord-009571-mygj2nd4 149 31 fixing fix VBG cord-009571-mygj2nd4 149 32 a a DT cord-009571-mygj2nd4 149 33 - - HYPH cord-009571-mygj2nd4 149 34 DNA(CL dna(cl NN cord-009571-mygj2nd4 149 35 ) ) -RRB- cord-009571-mygj2nd4 149 36 may may MD cord-009571-mygj2nd4 149 37 reflect reflect VB cord-009571-mygj2nd4 149 38 total total JJ cord-009571-mygj2nd4 149 39 amount amount NN cord-009571-mygj2nd4 149 40 of of IN cord-009571-mygj2nd4 149 41 antibody antibody NN cord-009571-mygj2nd4 149 42 ; ; : cord-009571-mygj2nd4 149 43 demonstration demonstration NN cord-009571-mygj2nd4 149 44 of of IN cord-009571-mygj2nd4 149 45 C c NN cord-009571-mygj2nd4 149 46 - - HYPH cord-009571-mygj2nd4 149 47 fixing fix VBG cord-009571-mygj2nd4 149 48 ability ability NN cord-009571-mygj2nd4 149 49 may may MD cord-009571-mygj2nd4 149 50 generally generally RB cord-009571-mygj2nd4 149 51 be be VB cord-009571-mygj2nd4 149 52 expected expect VBN cord-009571-mygj2nd4 149 53 in in IN cord-009571-mygj2nd4 149 54 high high JJ cord-009571-mygj2nd4 149 55 titered titered JJ cord-009571-mygj2nd4 149 56 sera sera NNP cord-009571-mygj2nd4 149 57 ; ; : cord-009571-mygj2nd4 149 58 3 3 LS cord-009571-mygj2nd4 149 59 ) ) -RRB- cord-009571-mygj2nd4 149 60 antibodies antibody NNS cord-009571-mygj2nd4 149 61 to to IN cord-009571-mygj2nd4 149 62 at at RB cord-009571-mygj2nd4 149 63 least least RBS cord-009571-mygj2nd4 149 64 2 2 CD cord-009571-mygj2nd4 149 65 sets set NNS cord-009571-mygj2nd4 149 66 of of IN cord-009571-mygj2nd4 149 67 constituents constituent NNS cord-009571-mygj2nd4 149 68 of of IN cord-009571-mygj2nd4 149 69 the the DT cord-009571-mygj2nd4 149 70 DNA dna NN cord-009571-mygj2nd4 149 71 preparation preparation NN cord-009571-mygj2nd4 149 72 employed employ VBN cord-009571-mygj2nd4 149 73 in in IN cord-009571-mygj2nd4 149 74 the the DT cord-009571-mygj2nd4 149 75 MF MF NNP cord-009571-mygj2nd4 149 76 method method NN cord-009571-mygj2nd4 149 77 can can MD cord-009571-mygj2nd4 149 78 be be VB cord-009571-mygj2nd4 149 79 detected detect VBN cord-009571-mygj2nd4 149 80 , , , cord-009571-mygj2nd4 149 81 one one CD cord-009571-mygj2nd4 149 82 occurring occur VBG cord-009571-mygj2nd4 149 83 in in IN cord-009571-mygj2nd4 149 84 active active JJ cord-009571-mygj2nd4 149 85 lupus lupus NN cord-009571-mygj2nd4 149 86 nephritis nephritis NN cord-009571-mygj2nd4 149 87 and and CC cord-009571-mygj2nd4 149 88 correlated correlate VBN cord-009571-mygj2nd4 149 89 with with IN cord-009571-mygj2nd4 149 90 antibodies antibody NNS cord-009571-mygj2nd4 149 91 detected detect VBN cord-009571-mygj2nd4 149 92 by by IN cord-009571-mygj2nd4 149 93 CL CL NNP cord-009571-mygj2nd4 149 94 , , , cord-009571-mygj2nd4 149 95 and and CC cord-009571-mygj2nd4 149 96 one one CD cord-009571-mygj2nd4 149 97 in in IN cord-009571-mygj2nd4 149 98 patients patient NNS cord-009571-mygj2nd4 149 99 with with IN cord-009571-mygj2nd4 149 100 active active JJ cord-009571-mygj2nd4 149 101 lupus lupus NN cord-009571-mygj2nd4 149 102 without without IN cord-009571-mygj2nd4 149 103 nephritis nephritis NN cord-009571-mygj2nd4 149 104 , , , cord-009571-mygj2nd4 149 105 detected detect VBD cord-009571-mygj2nd4 149 106 minimally minimally RB cord-009571-mygj2nd4 149 107 or or CC cord-009571-mygj2nd4 149 108 not not RB cord-009571-mygj2nd4 149 109 at at RB cord-009571-mygj2nd4 149 110 all all RB cord-009571-mygj2nd4 149 111 by by IN cord-009571-mygj2nd4 149 112 the the DT cord-009571-mygj2nd4 149 113 CL CL NNP cord-009571-mygj2nd4 149 114 method method NN cord-009571-mygj2nd4 149 115 . . . cord-009571-mygj2nd4 150 1 Cell cell NN cord-009571-mygj2nd4 150 2 mediated mediate VBN cord-009571-mygj2nd4 150 3 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 150 4 is be VBZ cord-009571-mygj2nd4 150 5 an an DT cord-009571-mygj2nd4 150 6 important important JJ cord-009571-mygj2nd4 150 7 pathogenic pathogenic JJ cord-009571-mygj2nd4 150 8 mechanism mechanism NN cord-009571-mygj2nd4 150 9 in in IN cord-009571-mygj2nd4 150 10 certain certain JJ cord-009571-mygj2nd4 150 11 rheumatic rheumatic JJ cord-009571-mygj2nd4 150 12 diseases disease NNS cord-009571-mygj2nd4 150 13 . . . cord-009571-mygj2nd4 151 1 Recent recent JJ cord-009571-mygj2nd4 151 2 studies study NNS cord-009571-mygj2nd4 151 3 from from IN cord-009571-mygj2nd4 151 4 this this DT cord-009571-mygj2nd4 151 5 laboratory laboratory NN cord-009571-mygj2nd4 151 6 have have VBP cord-009571-mygj2nd4 151 7 demonstrated demonstrate VBN cord-009571-mygj2nd4 151 8 that that IN cord-009571-mygj2nd4 151 9 adherent adherent JJ cord-009571-mygj2nd4 151 10 monocytes monocyte NNS cord-009571-mygj2nd4 151 11 are be VBP cord-009571-mygj2nd4 151 12 potent potent JJ cord-009571-mygj2nd4 151 13 killers killer NNS cord-009571-mygj2nd4 151 14 of of IN cord-009571-mygj2nd4 151 15 antibody antibody NN cord-009571-mygj2nd4 151 16 coated coat VBN cord-009571-mygj2nd4 151 17 ( ( -LRB- cord-009571-mygj2nd4 151 18 ADCC ADCC NNP cord-009571-mygj2nd4 151 19 ) ) -RRB- cord-009571-mygj2nd4 151 20 nonerythroid nonerythroid NNP cord-009571-mygj2nd4 151 21 target target NNP cord-009571-mygj2nd4 151 22 cells cell NNS cord-009571-mygj2nd4 151 23 and and CC cord-009571-mygj2nd4 151 24 also also RB cord-009571-mygj2nd4 151 25 kill kill VBP cord-009571-mygj2nd4 151 26 uncoated uncoated JJ cord-009571-mygj2nd4 151 27 target target NN cord-009571-mygj2nd4 151 28 cells cell NNS cord-009571-mygj2nd4 151 29 to to IN cord-009571-mygj2nd4 151 30 a a DT cord-009571-mygj2nd4 151 31 lesser less JJR cord-009571-mygj2nd4 151 32 extent extent NN cord-009571-mygj2nd4 151 33 . . . cord-009571-mygj2nd4 152 1 Although although IN cord-009571-mygj2nd4 152 2 immune immune JJ cord-009571-mygj2nd4 152 3 complexes complex NNS cord-009571-mygj2nd4 152 4 can can MD cord-009571-mygj2nd4 152 5 inhibit inhibit VB cord-009571-mygj2nd4 152 6 lymphocyte lymphocyte NN cord-009571-mygj2nd4 152 7 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 152 8 , , , cord-009571-mygj2nd4 152 9 their -PRON- PRP$ cord-009571-mygj2nd4 152 10 effect effect NN cord-009571-mygj2nd4 152 11 on on IN cord-009571-mygj2nd4 152 12 monocyte monocyte JJ cord-009571-mygj2nd4 152 13 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 152 14 is be VBZ cord-009571-mygj2nd4 152 15 unknown unknown JJ cord-009571-mygj2nd4 152 16 . . . cord-009571-mygj2nd4 153 1 This this DT cord-009571-mygj2nd4 153 2 study study NN cord-009571-mygj2nd4 153 3 compares compare VBZ cord-009571-mygj2nd4 153 4 human human JJ cord-009571-mygj2nd4 153 5 monocytes monocyte NNS cord-009571-mygj2nd4 153 6 ADCC ADCC NNP cord-009571-mygj2nd4 153 7 and and CC cord-009571-mygj2nd4 153 8 natural natural JJ cord-009571-mygj2nd4 153 9 killer killer NN cord-009571-mygj2nd4 153 10 ( ( -LRB- cord-009571-mygj2nd4 153 11 NK NK NNP cord-009571-mygj2nd4 153 12 ) ) -RRB- cord-009571-mygj2nd4 153 13 activities activity NNS cord-009571-mygj2nd4 153 14 with with IN cord-009571-mygj2nd4 153 15 that that DT cord-009571-mygj2nd4 153 16 of of IN cord-009571-mygj2nd4 153 17 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 153 18 . . . cord-009571-mygj2nd4 154 1 The the DT cord-009571-mygj2nd4 154 2 effects effect NNS cord-009571-mygj2nd4 154 3 of of IN cord-009571-mygj2nd4 154 4 heat heat NN cord-009571-mygj2nd4 154 5 aggregated aggregate VBN cord-009571-mygj2nd4 154 6 IgG IgG NNP cord-009571-mygj2nd4 154 7 ( ( -LRB- cord-009571-mygj2nd4 154 8 0.02 0.02 CD cord-009571-mygj2nd4 154 9 - - SYM cord-009571-mygj2nd4 154 10 2 2 CD cord-009571-mygj2nd4 154 11 mg mg NN cord-009571-mygj2nd4 154 12 per per IN cord-009571-mygj2nd4 154 13 ml ml NN cord-009571-mygj2nd4 154 14 ) ) -RRB- cord-009571-mygj2nd4 154 15 and and CC cord-009571-mygj2nd4 154 16 preformed preform VBD cord-009571-mygj2nd4 154 17 soluble soluble JJ cord-009571-mygj2nd4 154 18 keyhole keyhole NN cord-009571-mygj2nd4 154 19 limpet limpet NN cord-009571-mygj2nd4 154 20 hemocyanin hemocyanin NN cord-009571-mygj2nd4 154 21 ( ( -LRB- cord-009571-mygj2nd4 154 22 KLH)/anti KLH)/anti NNP cord-009571-mygj2nd4 154 23 - - JJ cord-009571-mygj2nd4 154 24 KLH KLH NNP cord-009571-mygj2nd4 154 25 complexes complex NNS cord-009571-mygj2nd4 154 26 were be VBD cord-009571-mygj2nd4 154 27 evaluated evaluate VBN cord-009571-mygj2nd4 154 28 . . . cord-009571-mygj2nd4 155 1 Monocytes monocyte NNS cord-009571-mygj2nd4 155 2 and and CC cord-009571-mygj2nd4 155 3 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 155 4 were be VBD cord-009571-mygj2nd4 155 5 separated separate VBN cord-009571-mygj2nd4 155 6 by by IN cord-009571-mygj2nd4 155 7 their -PRON- PRP$ cord-009571-mygj2nd4 155 8 differential differential JJ cord-009571-mygj2nd4 155 9 adherence adherence NN cord-009571-mygj2nd4 155 10 properties property NNS cord-009571-mygj2nd4 155 11 in in IN cord-009571-mygj2nd4 155 12 plastic plastic JJ cord-009571-mygj2nd4 155 13 microtiter microtiter NN cord-009571-mygj2nd4 155 14 wells well NNS cord-009571-mygj2nd4 155 15 and and CC cord-009571-mygj2nd4 155 16 were be VBD cord-009571-mygj2nd4 155 17 at at RB cord-009571-mygj2nd4 155 18 least least RBS cord-009571-mygj2nd4 155 19 95 95 CD cord-009571-mygj2nd4 155 20 % % NN cord-009571-mygj2nd4 155 21 pure pure JJ cord-009571-mygj2nd4 155 22 . . . cord-009571-mygj2nd4 156 1 Cytotoxicity Cytotoxicity NNP cord-009571-mygj2nd4 156 2 was be VBD cord-009571-mygj2nd4 156 3 measured measure VBN cord-009571-mygj2nd4 156 4 by by IN cord-009571-mygj2nd4 156 5 " " `` cord-009571-mygj2nd4 156 6 chromium chromium NN cord-009571-mygj2nd4 156 7 released release VBN cord-009571-mygj2nd4 156 8 from from IN cord-009571-mygj2nd4 156 9 antibody antibody NN cord-009571-mygj2nd4 156 10 coated coat VBN cord-009571-mygj2nd4 156 11 ( ( -LRB- cord-009571-mygj2nd4 156 12 ADCC ADCC NNP cord-009571-mygj2nd4 156 13 ) ) -RRB- cord-009571-mygj2nd4 156 14 and and CC cord-009571-mygj2nd4 156 15 nonsensitized nonsensitize VBN cord-009571-mygj2nd4 156 16 ( ( -LRB- cord-009571-mygj2nd4 156 17 NK NK NNP cord-009571-mygj2nd4 156 18 ) ) -RRB- cord-009571-mygj2nd4 156 19 K K NNP cord-009571-mygj2nd4 156 20 562 562 CD cord-009571-mygj2nd4 156 21 cells cell NNS cord-009571-mygj2nd4 156 22 , , , cord-009571-mygj2nd4 156 23 an an DT cord-009571-mygj2nd4 156 24 established establish VBN cord-009571-mygj2nd4 156 25 myeloid myeloid JJ cord-009571-mygj2nd4 156 26 cell cell NN cord-009571-mygj2nd4 156 27 line line NN cord-009571-mygj2nd4 156 28 . . . cord-009571-mygj2nd4 157 1 Precipitated Precipitated NNP cord-009571-mygj2nd4 157 2 KLH KLH NNP cord-009571-mygj2nd4 157 3 / / SYM cord-009571-mygj2nd4 157 4 anti anti JJ cord-009571-mygj2nd4 157 5 - - JJ cord-009571-mygj2nd4 157 6 KLH KLH NNP cord-009571-mygj2nd4 157 7 complexes complex NNS cord-009571-mygj2nd4 157 8 formed form VBN cord-009571-mygj2nd4 157 9 at at IN cord-009571-mygj2nd4 157 10 equivalence equivalence NN cord-009571-mygj2nd4 157 11 were be VBD cord-009571-mygj2nd4 157 12 the the DT cord-009571-mygj2nd4 157 13 strongest strong JJS cord-009571-mygj2nd4 157 14 inhibitors inhibitor NNS cord-009571-mygj2nd4 157 15 of of IN cord-009571-mygj2nd4 157 16 cell cell NN cord-009571-mygj2nd4 157 17 mediated mediate VBN cord-009571-mygj2nd4 157 18 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 157 19 ( ( -LRB- cord-009571-mygj2nd4 157 20 suppression suppression NN cord-009571-mygj2nd4 157 21 : : : cord-009571-mygj2nd4 157 22 monocyte monocyte NNP cord-009571-mygj2nd4 157 23 NK NK NNP cord-009571-mygj2nd4 157 24 900/0 900/0 NNP cord-009571-mygj2nd4 157 25 , , , cord-009571-mygj2nd4 157 26 monocyte monocyte NNP cord-009571-mygj2nd4 157 27 ADCC ADCC NNP cord-009571-mygj2nd4 157 28 60 60 CD cord-009571-mygj2nd4 157 29 % % NN cord-009571-mygj2nd4 157 30 , , , cord-009571-mygj2nd4 157 31 lymphocyte lymphocyte NN cord-009571-mygj2nd4 157 32 NK NK NNP cord-009571-mygj2nd4 157 33 8O% 8o% CD cord-009571-mygj2nd4 157 34 , , , cord-009571-mygj2nd4 157 35 lymphocyte lymphocyte NN cord-009571-mygj2nd4 157 36 ADCC ADCC NNP cord-009571-mygj2nd4 157 37 30 30 CD cord-009571-mygj2nd4 157 38 % % NN cord-009571-mygj2nd4 157 39 ) ) -RRB- cord-009571-mygj2nd4 157 40 . . . cord-009571-mygj2nd4 158 1 Aggregated aggregated JJ cord-009571-mygj2nd4 158 2 IgG igg NN cord-009571-mygj2nd4 158 3 also also RB cord-009571-mygj2nd4 158 4 strongly strongly RB cord-009571-mygj2nd4 158 5 inhibited inhibit VBD cord-009571-mygj2nd4 158 6 both both CC cord-009571-mygj2nd4 158 7 monocyte monocyte JJ cord-009571-mygj2nd4 158 8 and and CC cord-009571-mygj2nd4 158 9 lymphocyte lymphocyte NN cord-009571-mygj2nd4 158 10 NK nk NN cord-009571-mygj2nd4 158 11 ( ( -LRB- cord-009571-mygj2nd4 158 12 50 50 CD cord-009571-mygj2nd4 158 13 % % NN cord-009571-mygj2nd4 158 14 and and CC cord-009571-mygj2nd4 158 15 75 75 CD cord-009571-mygj2nd4 158 16 % % NN cord-009571-mygj2nd4 158 17 respectively respectively RB cord-009571-mygj2nd4 158 18 ) ) -RRB- cord-009571-mygj2nd4 158 19 and and CC cord-009571-mygj2nd4 158 20 also also RB cord-009571-mygj2nd4 158 21 suppressed suppress VBD cord-009571-mygj2nd4 158 22 ADCC ADCC NNP cord-009571-mygj2nd4 158 23 to to IN cord-009571-mygj2nd4 158 24 a a DT cord-009571-mygj2nd4 158 25 lesser less JJR cord-009571-mygj2nd4 158 26 extent extent NN cord-009571-mygj2nd4 158 27 ( ( -LRB- cord-009571-mygj2nd4 158 28 monocyte monocyte NNP cord-009571-mygj2nd4 158 29 25 25 CD cord-009571-mygj2nd4 158 30 % % NN cord-009571-mygj2nd4 158 31 , , , cord-009571-mygj2nd4 158 32 lymphocyte lymphocyte NN cord-009571-mygj2nd4 158 33 20 20 CD cord-009571-mygj2nd4 158 34 % % NN cord-009571-mygj2nd4 158 35 ) ) -RRB- cord-009571-mygj2nd4 158 36 . . . cord-009571-mygj2nd4 159 1 KLH KLH NNP cord-009571-mygj2nd4 159 2 / / SYM cord-009571-mygj2nd4 159 3 anti anti JJ cord-009571-mygj2nd4 159 4 - - NNP cord-009571-mygj2nd4 159 5 KLH KLH NNP cord-009571-mygj2nd4 159 6 in in IN cord-009571-mygj2nd4 159 7 antigen antigen NN cord-009571-mygj2nd4 159 8 excess excess NN cord-009571-mygj2nd4 159 9 had have VBD cord-009571-mygj2nd4 159 10 no no DT cord-009571-mygj2nd4 159 11 effect effect NN cord-009571-mygj2nd4 159 12 on on IN cord-009571-mygj2nd4 159 13 monocyte monocyte NNP cord-009571-mygj2nd4 159 14 NK NK NNP cord-009571-mygj2nd4 159 15 and and CC cord-009571-mygj2nd4 159 16 suppressed suppress VBD cord-009571-mygj2nd4 159 17 lymphocyte lymphocyte NN cord-009571-mygj2nd4 159 18 NK nk NN cord-009571-mygj2nd4 159 19 by by IN cord-009571-mygj2nd4 159 20 only only RB cord-009571-mygj2nd4 159 21 25 25 CD cord-009571-mygj2nd4 159 22 % % NN cord-009571-mygj2nd4 159 23 . . . cord-009571-mygj2nd4 160 1 Although although IN cord-009571-mygj2nd4 160 2 soluble soluble JJ cord-009571-mygj2nd4 160 3 complexes complex NNS cord-009571-mygj2nd4 160 4 did do VBD cord-009571-mygj2nd4 160 5 not not RB cord-009571-mygj2nd4 160 6 block block VB cord-009571-mygj2nd4 160 7 monocyte monocyte NNP cord-009571-mygj2nd4 160 8 NK NK NNP cord-009571-mygj2nd4 160 9 , , , cord-009571-mygj2nd4 160 10 they -PRON- PRP cord-009571-mygj2nd4 160 11 did do VBD cord-009571-mygj2nd4 160 12 significantly significantly RB cord-009571-mygj2nd4 160 13 block block VB cord-009571-mygj2nd4 160 14 monocyte monocyte NNP cord-009571-mygj2nd4 160 15 ADCC ADCC NNP cord-009571-mygj2nd4 160 16 ( ( -LRB- cord-009571-mygj2nd4 160 17 45 45 CD cord-009571-mygj2nd4 160 18 % % NN cord-009571-mygj2nd4 160 19 ) ) -RRB- cord-009571-mygj2nd4 160 20 . . . cord-009571-mygj2nd4 161 1 By by IN cord-009571-mygj2nd4 161 2 use use NN cord-009571-mygj2nd4 161 3 of of IN cord-009571-mygj2nd4 161 4 serial serial JJ cord-009571-mygj2nd4 161 5 dilutions dilution NNS cord-009571-mygj2nd4 161 6 of of IN cord-009571-mygj2nd4 161 7 complexes complex NNS cord-009571-mygj2nd4 161 8 in in IN cord-009571-mygj2nd4 161 9 aggregated aggregated JJ cord-009571-mygj2nd4 161 10 IgG igg NN cord-009571-mygj2nd4 161 11 , , , cord-009571-mygj2nd4 161 12 a a DT cord-009571-mygj2nd4 161 13 dose dose JJ cord-009571-mygj2nd4 161 14 dependent dependent JJ cord-009571-mygj2nd4 161 15 relationship relationship NN cord-009571-mygj2nd4 161 16 was be VBD cord-009571-mygj2nd4 161 17 established establish VBN cord-009571-mygj2nd4 161 18 between between IN cord-009571-mygj2nd4 161 19 complexes complex NNS cord-009571-mygj2nd4 161 20 and and CC cord-009571-mygj2nd4 161 21 percent percent NN cord-009571-mygj2nd4 161 22 suppression suppression NN cord-009571-mygj2nd4 161 23 of of IN cord-009571-mygj2nd4 161 24 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 161 25 . . . cord-009571-mygj2nd4 162 1 These these DT cord-009571-mygj2nd4 162 2 studies study NNS cord-009571-mygj2nd4 162 3 reveal reveal VBP cord-009571-mygj2nd4 162 4 that that IN cord-009571-mygj2nd4 162 5 both both DT cord-009571-mygj2nd4 162 6 KLH KLH NNP cord-009571-mygj2nd4 162 7 / / SYM cord-009571-mygj2nd4 162 8 anti anti JJ cord-009571-mygj2nd4 162 9 - - JJ cord-009571-mygj2nd4 162 10 KLH KLH NNP cord-009571-mygj2nd4 162 11 immune immune JJ cord-009571-mygj2nd4 162 12 complexes complex NNS cord-009571-mygj2nd4 162 13 and and CC cord-009571-mygj2nd4 162 14 aggregated aggregated JJ cord-009571-mygj2nd4 162 15 IgG igg NN cord-009571-mygj2nd4 162 16 can can MD cord-009571-mygj2nd4 162 17 inhibit inhibit VB cord-009571-mygj2nd4 162 18 monocyte monocyte JJ cord-009571-mygj2nd4 162 19 cytotoxic cytotoxic JJ cord-009571-mygj2nd4 162 20 activity activity NN cord-009571-mygj2nd4 162 21 and and CC cord-009571-mygj2nd4 162 22 that that IN cord-009571-mygj2nd4 162 23 , , , cord-009571-mygj2nd4 162 24 in in IN cord-009571-mygj2nd4 162 25 general general JJ cord-009571-mygj2nd4 162 26 , , , cord-009571-mygj2nd4 162 27 these these DT cord-009571-mygj2nd4 162 28 effects effect NNS cord-009571-mygj2nd4 162 29 correlated correlate VBN cord-009571-mygj2nd4 162 30 with with IN cord-009571-mygj2nd4 162 31 lymphocyte lymphocyte NN cord-009571-mygj2nd4 162 32 NK NK NNP cord-009571-mygj2nd4 162 33 and and CC cord-009571-mygj2nd4 162 34 ADCC ADCC NNP cord-009571-mygj2nd4 162 35 . . . cord-009571-mygj2nd4 163 1 Significant significant JJ cord-009571-mygj2nd4 163 2 differences difference NNS cord-009571-mygj2nd4 163 3 between between IN cord-009571-mygj2nd4 163 4 soluble soluble JJ cord-009571-mygj2nd4 163 5 immune immune JJ cord-009571-mygj2nd4 163 6 complexes complex NNS cord-009571-mygj2nd4 163 7 and and CC cord-009571-mygj2nd4 163 8 aggregated aggregated JJ cord-009571-mygj2nd4 163 9 IgG IgG NNP cord-009571-mygj2nd4 163 10 were be VBD cord-009571-mygj2nd4 163 11 demonstrated demonstrate VBN cord-009571-mygj2nd4 163 12 . . . cord-009571-mygj2nd4 164 1 Finally finally RB cord-009571-mygj2nd4 164 2 , , , cord-009571-mygj2nd4 164 3 the the DT cord-009571-mygj2nd4 164 4 finding finding NN cord-009571-mygj2nd4 164 5 that that IN cord-009571-mygj2nd4 164 6 certain certain JJ cord-009571-mygj2nd4 164 7 immune immune JJ cord-009571-mygj2nd4 164 8 complexes complex NNS cord-009571-mygj2nd4 164 9 inhibit inhibit VBP cord-009571-mygj2nd4 164 10 both both DT cord-009571-mygj2nd4 164 11 NK NK NNP cord-009571-mygj2nd4 164 12 and and CC cord-009571-mygj2nd4 164 13 ADCC ADCC NNP cord-009571-mygj2nd4 164 14 would would MD cord-009571-mygj2nd4 164 15 imply imply VB cord-009571-mygj2nd4 164 16 that that IN cord-009571-mygj2nd4 164 17 Fc Fc NNP cord-009571-mygj2nd4 164 18 receptors receptor NNS cord-009571-mygj2nd4 164 19 are be VBP cord-009571-mygj2nd4 164 20 required require VBN cord-009571-mygj2nd4 164 21 for for IN cord-009571-mygj2nd4 164 22 both both DT cord-009571-mygj2nd4 164 23 cytotoxic cytotoxic JJ cord-009571-mygj2nd4 164 24 responses response NNS cord-009571-mygj2nd4 164 25 . . . cord-009571-mygj2nd4 165 1 The the DT cord-009571-mygj2nd4 165 2 relatively relatively RB cord-009571-mygj2nd4 165 3 greater great JJR cord-009571-mygj2nd4 165 4 inhibitory inhibitory JJ cord-009571-mygj2nd4 165 5 effect effect NN cord-009571-mygj2nd4 165 6 on on IN cord-009571-mygj2nd4 165 7 NK NK NNP cord-009571-mygj2nd4 165 8 would would MD cord-009571-mygj2nd4 165 9 imply imply VB cord-009571-mygj2nd4 165 10 that that IN cord-009571-mygj2nd4 165 11 antibody antibody NN cord-009571-mygj2nd4 165 12 fixed fix VBN cord-009571-mygj2nd4 165 13 to to TO cord-009571-mygj2nd4 165 14 target target VB cord-009571-mygj2nd4 165 15 cells cell NNS cord-009571-mygj2nd4 165 16 potentiates potentiate VBZ cord-009571-mygj2nd4 165 17 attachment attachment NN cord-009571-mygj2nd4 165 18 by by IN cord-009571-mygj2nd4 165 19 the the DT cord-009571-mygj2nd4 165 20 effector effector NN cord-009571-mygj2nd4 165 21 cell cell NN cord-009571-mygj2nd4 165 22 and and CC cord-009571-mygj2nd4 165 23 renders render VBZ cord-009571-mygj2nd4 165 24 it -PRON- PRP cord-009571-mygj2nd4 165 25 less less RBR cord-009571-mygj2nd4 165 26 susceptible susceptible JJ cord-009571-mygj2nd4 165 27 to to IN cord-009571-mygj2nd4 165 28 inhibition inhibition NN cord-009571-mygj2nd4 165 29 by by IN cord-009571-mygj2nd4 165 30 immune immune JJ cord-009571-mygj2nd4 165 31 complexes complex NNS cord-009571-mygj2nd4 165 32 . . . cord-009571-mygj2nd4 166 1 Gout gout NN cord-009571-mygj2nd4 166 2 is be VBZ cord-009571-mygj2nd4 166 3 easily easily RB cord-009571-mygj2nd4 166 4 diagnosed diagnose VBN cord-009571-mygj2nd4 166 5 from from IN cord-009571-mygj2nd4 166 6 a a DT cord-009571-mygj2nd4 166 7 classic classic JJ cord-009571-mygj2nd4 166 8 clinical clinical JJ cord-009571-mygj2nd4 166 9 history history NN cord-009571-mygj2nd4 166 10 and and CC cord-009571-mygj2nd4 166 11 the the DT cord-009571-mygj2nd4 166 12 demonstration demonstration NN cord-009571-mygj2nd4 166 13 of of IN cord-009571-mygj2nd4 166 14 urate urate NN cord-009571-mygj2nd4 166 15 crystals crystal NNS cord-009571-mygj2nd4 166 16 in in IN cord-009571-mygj2nd4 166 17 synovial synovial JJ cord-009571-mygj2nd4 166 18 fluid fluid NN cord-009571-mygj2nd4 166 19 and/ and/ NNP cord-009571-mygj2nd4 166 20 or or CC cord-009571-mygj2nd4 166 21 tophi tophi NNP cord-009571-mygj2nd4 166 22 ; ; : cord-009571-mygj2nd4 166 23 however however RB cord-009571-mygj2nd4 166 24 the the DT cord-009571-mygj2nd4 166 25 diagnosis diagnosis NN cord-009571-mygj2nd4 166 26 may may MD cord-009571-mygj2nd4 166 27 not not RB cord-009571-mygj2nd4 166 28 be be VB cord-009571-mygj2nd4 166 29 suspected suspect VBN cord-009571-mygj2nd4 166 30 in in IN cord-009571-mygj2nd4 166 31 patients patient NNS cord-009571-mygj2nd4 166 32 with with IN cord-009571-mygj2nd4 166 33 an an DT cord-009571-mygj2nd4 166 34 atypical atypical JJ cord-009571-mygj2nd4 166 35 history history NN cord-009571-mygj2nd4 166 36 or or CC cord-009571-mygj2nd4 166 37 physical physical JJ cord-009571-mygj2nd4 166 38 examination examination NN cord-009571-mygj2nd4 166 39 . . . cord-009571-mygj2nd4 167 1 To to TO cord-009571-mygj2nd4 167 2 ascertain ascertain VB cord-009571-mygj2nd4 167 3 the the DT cord-009571-mygj2nd4 167 4 prevalence prevalence NN cord-009571-mygj2nd4 167 5 of of IN cord-009571-mygj2nd4 167 6 atypical atypical JJ cord-009571-mygj2nd4 167 7 findings finding NNS cord-009571-mygj2nd4 167 8 we -PRON- PRP cord-009571-mygj2nd4 167 9 are be VBP cord-009571-mygj2nd4 167 10 conducting conduct VBG cord-009571-mygj2nd4 167 11 a a DT cord-009571-mygj2nd4 167 12 prospective prospective JJ cord-009571-mygj2nd4 167 13 study study NN cord-009571-mygj2nd4 167 14 in in IN cord-009571-mygj2nd4 167 15 our -PRON- PRP$ cord-009571-mygj2nd4 167 16 gouty gouty JJ cord-009571-mygj2nd4 167 17 population population NN cord-009571-mygj2nd4 167 18 randomly randomly RB cord-009571-mygj2nd4 167 19 admitted admit VBD cord-009571-mygj2nd4 167 20 to to IN cord-009571-mygj2nd4 167 21 the the DT cord-009571-mygj2nd4 167 22 Clinical Clinical NNP cord-009571-mygj2nd4 167 23 Research Research NNP cord-009571-mygj2nd4 167 24 Unit Unit NNP cord-009571-mygj2nd4 167 25 . . . cord-009571-mygj2nd4 168 1 We -PRON- PRP cord-009571-mygj2nd4 168 2 report report VBP cord-009571-mygj2nd4 168 3 the the DT cord-009571-mygj2nd4 168 4 following follow VBG cord-009571-mygj2nd4 168 5 findings finding NNS cord-009571-mygj2nd4 168 6 in in IN cord-009571-mygj2nd4 168 7 the the DT cord-009571-mygj2nd4 168 8 first first JJ cord-009571-mygj2nd4 168 9 30 30 CD cord-009571-mygj2nd4 168 10 patients patient NNS cord-009571-mygj2nd4 168 11 with with IN cord-009571-mygj2nd4 168 12 crystal crystal NN cord-009571-mygj2nd4 168 13 proved prove VBN cord-009571-mygj2nd4 168 14 gout gout NN cord-009571-mygj2nd4 168 15 : : : cord-009571-mygj2nd4 168 16 1 1 LS cord-009571-mygj2nd4 168 17 ) ) -RRB- cord-009571-mygj2nd4 168 18 30 30 CD cord-009571-mygj2nd4 168 19 % % NN cord-009571-mygj2nd4 168 20 had have VBD cord-009571-mygj2nd4 168 21 saturnine saturnine JJ cord-009571-mygj2nd4 168 22 gout gout NN cord-009571-mygj2nd4 168 23 2 2 CD cord-009571-mygj2nd4 168 24 " " '' cord-009571-mygj2nd4 168 25 to to IN cord-009571-mygj2nd4 168 26 moonshine moonshine NN cord-009571-mygj2nd4 168 27 consumption consumption NN cord-009571-mygj2nd4 168 28 , , , cord-009571-mygj2nd4 168 29 37 37 CD cord-009571-mygj2nd4 168 30 % % NN cord-009571-mygj2nd4 168 31 gave give VBD cord-009571-mygj2nd4 168 32 a a DT cord-009571-mygj2nd4 168 33 history history NN cord-009571-mygj2nd4 168 34 of of IN cord-009571-mygj2nd4 168 35 heavy heavy JJ cord-009571-mygj2nd4 168 36 ethanol ethanol NN cord-009571-mygj2nd4 168 37 consumption consumption NN cord-009571-mygj2nd4 168 38 but but CC cord-009571-mygj2nd4 168 39 did do VBD cord-009571-mygj2nd4 168 40 not not RB cord-009571-mygj2nd4 168 41 have have VB cord-009571-mygj2nd4 168 42 lead lead JJ cord-009571-mygj2nd4 168 43 intoxication intoxication NN cord-009571-mygj2nd4 168 44 , , , cord-009571-mygj2nd4 168 45 and and CC cord-009571-mygj2nd4 168 46 53 53 CD cord-009571-mygj2nd4 168 47 % % NN cord-009571-mygj2nd4 168 48 were be VBD cord-009571-mygj2nd4 168 49 obese obese JJ cord-009571-mygj2nd4 168 50 . . . cord-009571-mygj2nd4 169 1 All all DT cord-009571-mygj2nd4 169 2 patients patient NNS cord-009571-mygj2nd4 169 3 were be VBD cord-009571-mygj2nd4 169 4 male male JJ cord-009571-mygj2nd4 169 5 , , , cord-009571-mygj2nd4 169 6 53 53 CD cord-009571-mygj2nd4 169 7 % % NN cord-009571-mygj2nd4 169 8 black black JJ cord-009571-mygj2nd4 169 9 , , , cord-009571-mygj2nd4 169 10 40 40 CD cord-009571-mygj2nd4 169 11 % % NN cord-009571-mygj2nd4 169 12 white white JJ cord-009571-mygj2nd4 169 13 and and CC cord-009571-mygj2nd4 169 14 7 7 CD cord-009571-mygj2nd4 169 15 % % NN cord-009571-mygj2nd4 169 16 American American NNP cord-009571-mygj2nd4 169 17 Indian Indian NNP cord-009571-mygj2nd4 169 18 . . . cord-009571-mygj2nd4 170 1 The the DT cord-009571-mygj2nd4 170 2 average average JJ cord-009571-mygj2nd4 170 3 age age NN cord-009571-mygj2nd4 170 4 at at IN cord-009571-mygj2nd4 170 5 the the DT cord-009571-mygj2nd4 170 6 time time NN cord-009571-mygj2nd4 170 7 of of IN cord-009571-mygj2nd4 170 8 study study NN cord-009571-mygj2nd4 170 9 was be VBD cord-009571-mygj2nd4 170 10 53.2 53.2 CD cord-009571-mygj2nd4 170 11 years year NNS cord-009571-mygj2nd4 170 12 with with IN cord-009571-mygj2nd4 170 13 a a DT cord-009571-mygj2nd4 170 14 mean mean JJ cord-009571-mygj2nd4 170 15 duration duration NN cord-009571-mygj2nd4 170 16 of of IN cord-009571-mygj2nd4 170 17 gout gout NN cord-009571-mygj2nd4 170 18 of of IN cord-009571-mygj2nd4 170 19 14 14 CD cord-009571-mygj2nd4 170 20 years year NNS cord-009571-mygj2nd4 170 21 . . . cord-009571-mygj2nd4 171 1 Seventythree seventythree JJ cord-009571-mygj2nd4 171 2 percent percent NN cord-009571-mygj2nd4 171 3 had have VBD cord-009571-mygj2nd4 171 4 evidence evidence NN cord-009571-mygj2nd4 171 5 of of IN cord-009571-mygj2nd4 171 6 liver liver NN cord-009571-mygj2nd4 171 7 disease disease NN cord-009571-mygj2nd4 171 8 ( ( -LRB- cord-009571-mygj2nd4 171 9 elevated elevate VBN cord-009571-mygj2nd4 171 10 SGOT SGOT NNP cord-009571-mygj2nd4 171 11 or or CC cord-009571-mygj2nd4 171 12 hepatomegaly hepatomegaly NNP cord-009571-mygj2nd4 171 13 ) ) -RRB- cord-009571-mygj2nd4 171 14 , , , cord-009571-mygj2nd4 171 15 77 77 CD cord-009571-mygj2nd4 171 16 % % NN cord-009571-mygj2nd4 171 17 were be VBD cord-009571-mygj2nd4 171 18 hypertensive hypertensive JJ cord-009571-mygj2nd4 171 19 , , , cord-009571-mygj2nd4 171 20 47 47 CD cord-009571-mygj2nd4 171 21 % % NN cord-009571-mygj2nd4 171 22 had have VBD cord-009571-mygj2nd4 171 23 elevated elevate VBN cord-009571-mygj2nd4 171 24 triglycerides triglyceride NNS cord-009571-mygj2nd4 171 25 , , , cord-009571-mygj2nd4 171 26 and and CC cord-009571-mygj2nd4 171 27 47 47 CD cord-009571-mygj2nd4 171 28 % % NN cord-009571-mygj2nd4 171 29 had have VBD cord-009571-mygj2nd4 171 30 abnormal abnormal JJ cord-009571-mygj2nd4 171 31 glucose glucose NN cord-009571-mygj2nd4 171 32 tolerance tolerance NN cord-009571-mygj2nd4 171 33 . . . cord-009571-mygj2nd4 172 1 2 2 LS cord-009571-mygj2nd4 172 2 ) ) -RRB- cord-009571-mygj2nd4 172 3 Twenty twenty CD cord-009571-mygj2nd4 172 4 - - HYPH cord-009571-mygj2nd4 172 5 seven seven CD cord-009571-mygj2nd4 172 6 percent percent NN cord-009571-mygj2nd4 172 7 had have VBD cord-009571-mygj2nd4 172 8 a a DT cord-009571-mygj2nd4 172 9 polyarticular polyarticular JJ cord-009571-mygj2nd4 172 10 onset onset NN cord-009571-mygj2nd4 172 11 of of IN cord-009571-mygj2nd4 172 12 gout gout NN cord-009571-mygj2nd4 172 13 ( ( -LRB- cord-009571-mygj2nd4 172 14 > > NFP cord-009571-mygj2nd4 172 15 1 1 CD cord-009571-mygj2nd4 172 16 joint joint NN cord-009571-mygj2nd4 172 17 ) ) -RRB- cord-009571-mygj2nd4 172 18 ; ; : cord-009571-mygj2nd4 172 19 60 60 CD cord-009571-mygj2nd4 172 20 % % NN cord-009571-mygj2nd4 172 21 subsequently subsequently RB cord-009571-mygj2nd4 172 22 had have VBD cord-009571-mygj2nd4 172 23 polyarticular polyarticular JJ cord-009571-mygj2nd4 172 24 attacks attack NNS cord-009571-mygj2nd4 172 25 . . . cord-009571-mygj2nd4 173 1 Seventythree seventythree JJ cord-009571-mygj2nd4 173 2 percent percent NN cord-009571-mygj2nd4 173 3 had have VBD cord-009571-mygj2nd4 173 4 tophi tophi NNP cord-009571-mygj2nd4 173 5 at at IN cord-009571-mygj2nd4 173 6 the the DT cord-009571-mygj2nd4 173 7 time time NN cord-009571-mygj2nd4 173 8 of of IN cord-009571-mygj2nd4 173 9 the the DT cord-009571-mygj2nd4 173 10 study study NN cord-009571-mygj2nd4 173 11 . . . cord-009571-mygj2nd4 174 1 Chronic Chronic NNP cord-009571-mygj2nd4 174 2 synovitis synovitis NN cord-009571-mygj2nd4 174 3 was be VBD cord-009571-mygj2nd4 174 4 present present JJ cord-009571-mygj2nd4 174 5 in in IN cord-009571-mygj2nd4 174 6 63 63 CD cord-009571-mygj2nd4 174 7 % % NN cord-009571-mygj2nd4 174 8 of of IN cord-009571-mygj2nd4 174 9 patients patient NNS cord-009571-mygj2nd4 174 10 . . . cord-009571-mygj2nd4 175 1 In in IN cord-009571-mygj2nd4 175 2 the the DT cord-009571-mygj2nd4 175 3 30 30 CD cord-009571-mygj2nd4 175 4 patients patient NNS cord-009571-mygj2nd4 175 5 examined examine VBD cord-009571-mygj2nd4 175 6 the the DT cord-009571-mygj2nd4 175 7 following follow VBG cord-009571-mygj2nd4 175 8 joints joint NNS cord-009571-mygj2nd4 175 9 of of IN cord-009571-mygj2nd4 175 10 the the DT cord-009571-mygj2nd4 175 11 upper upper JJ cord-009571-mygj2nd4 175 12 extremity extremity NN cord-009571-mygj2nd4 175 13 were be VBD cord-009571-mygj2nd4 175 14 involved involve VBN cord-009571-mygj2nd4 175 15 ; ; : cord-009571-mygj2nd4 175 16 40 40 CD cord-009571-mygj2nd4 175 17 % % NN cord-009571-mygj2nd4 175 18 M m NN cord-009571-mygj2nd4 175 19 P p NN cord-009571-mygj2nd4 175 20 and/or and/or CC cord-009571-mygj2nd4 175 21 IP IP NNP cord-009571-mygj2nd4 175 22 , , , cord-009571-mygj2nd4 175 23 20 20 CD cord-009571-mygj2nd4 175 24 % % NN cord-009571-mygj2nd4 175 25 wrist wrist NN cord-009571-mygj2nd4 175 26 , , , cord-009571-mygj2nd4 175 27 209'0 209'0 DT cord-009571-mygj2nd4 175 28 elbow elbow NN cord-009571-mygj2nd4 175 29 , , , cord-009571-mygj2nd4 175 30 10 10 CD cord-009571-mygj2nd4 175 31 % % NN cord-009571-mygj2nd4 175 32 shoulder shoulder NN cord-009571-mygj2nd4 175 33 . . . cord-009571-mygj2nd4 176 1 In in IN cord-009571-mygj2nd4 176 2 the the DT cord-009571-mygj2nd4 176 3 lower low JJR cord-009571-mygj2nd4 176 4 extremity extremity NN cord-009571-mygj2nd4 176 5 the the DT cord-009571-mygj2nd4 176 6 knee knee NN cord-009571-mygj2nd4 176 7 was be VBD cord-009571-mygj2nd4 176 8 involved involve VBN cord-009571-mygj2nd4 176 9 in in IN cord-009571-mygj2nd4 176 10 40 40 CD cord-009571-mygj2nd4 176 11 % % NN cord-009571-mygj2nd4 176 12 , , , cord-009571-mygj2nd4 176 13 M M NNP cord-009571-mygj2nd4 176 14 P P NNP cord-009571-mygj2nd4 176 15 joints joint NNS cord-009571-mygj2nd4 176 16 in in IN cord-009571-mygj2nd4 176 17 27 27 CD cord-009571-mygj2nd4 176 18 % % NN cord-009571-mygj2nd4 176 19 , , , cord-009571-mygj2nd4 176 20 and and CC cord-009571-mygj2nd4 176 21 ankles ankle NNS cord-009571-mygj2nd4 176 22 in in IN cord-009571-mygj2nd4 176 23 13 13 CD cord-009571-mygj2nd4 176 24 % % NN cord-009571-mygj2nd4 176 25 . . . cord-009571-mygj2nd4 177 1 3 3 LS cord-009571-mygj2nd4 177 2 ) ) -RRB- cord-009571-mygj2nd4 178 1 A a DT cord-009571-mygj2nd4 178 2 positive positive JJ cord-009571-mygj2nd4 178 3 latex latex NN cord-009571-mygj2nd4 178 4 fixation fixation NN cord-009571-mygj2nd4 178 5 test test NN cord-009571-mygj2nd4 178 6 was be VBD cord-009571-mygj2nd4 178 7 observed observe VBN cord-009571-mygj2nd4 178 8 in in IN cord-009571-mygj2nd4 178 9 31 31 CD cord-009571-mygj2nd4 178 10 % % NN cord-009571-mygj2nd4 178 11 of of IN cord-009571-mygj2nd4 178 12 patients patient NNS cord-009571-mygj2nd4 178 13 ; ; : cord-009571-mygj2nd4 178 14 6 6 CD cord-009571-mygj2nd4 178 15 being being NN cord-009571-mygj2nd4 178 16 > > XX cord-009571-mygj2nd4 178 17 1 1 CD cord-009571-mygj2nd4 178 18 : : SYM cord-009571-mygj2nd4 178 19 40 40 CD cord-009571-mygj2nd4 178 20 and and CC cord-009571-mygj2nd4 178 21 4 4 CD cord-009571-mygj2nd4 178 22 > > SYM cord-009571-mygj2nd4 178 23 1 1 CD cord-009571-mygj2nd4 178 24 : : : cord-009571-mygj2nd4 178 25 320 320 CD cord-009571-mygj2nd4 178 26 . . . cord-009571-mygj2nd4 179 1 RA RA NNP cord-009571-mygj2nd4 179 2 latex latex NN cord-009571-mygj2nd4 179 3 was be VBD cord-009571-mygj2nd4 179 4 present present JJ cord-009571-mygj2nd4 179 5 in in IN cord-009571-mygj2nd4 179 6 36 36 CD cord-009571-mygj2nd4 179 7 % % NN cord-009571-mygj2nd4 179 8 of of IN cord-009571-mygj2nd4 179 9 patients patient NNS cord-009571-mygj2nd4 179 10 with with IN cord-009571-mygj2nd4 179 11 tophi tophi NNP cord-009571-mygj2nd4 179 12 and and CC cord-009571-mygj2nd4 179 13 38 38 CD cord-009571-mygj2nd4 179 14 % % NN cord-009571-mygj2nd4 179 15 of of IN cord-009571-mygj2nd4 179 16 patients patient NNS cord-009571-mygj2nd4 179 17 without without IN cord-009571-mygj2nd4 179 18 tophaceous tophaceous JJ cord-009571-mygj2nd4 179 19 deposits deposit NNS cord-009571-mygj2nd4 179 20 . . . cord-009571-mygj2nd4 180 1 In in IN cord-009571-mygj2nd4 180 2 the the DT cord-009571-mygj2nd4 180 3 patients patient NNS cord-009571-mygj2nd4 180 4 with with IN cord-009571-mygj2nd4 180 5 chronic chronic JJ cord-009571-mygj2nd4 180 6 synovitis synovitis NNP cord-009571-mygj2nd4 180 7 37 37 CD cord-009571-mygj2nd4 180 8 % % NN cord-009571-mygj2nd4 180 9 had have VBD cord-009571-mygj2nd4 180 10 a a DT cord-009571-mygj2nd4 180 11 + + `` cord-009571-mygj2nd4 180 12 RA RA NNP cord-009571-mygj2nd4 180 13 latex latex NN cord-009571-mygj2nd4 180 14 , , , cord-009571-mygj2nd4 180 15 and and CC cord-009571-mygj2nd4 180 16 36 36 CD cord-009571-mygj2nd4 180 17 % % NN cord-009571-mygj2nd4 180 18 free free JJ cord-009571-mygj2nd4 180 19 of of IN cord-009571-mygj2nd4 180 20 chronic chronic JJ cord-009571-mygj2nd4 180 21 synovitis synovitis NNP cord-009571-mygj2nd4 180 22 were be VBD cord-009571-mygj2nd4 180 23 also also RB cord-009571-mygj2nd4 180 24 positive positive JJ cord-009571-mygj2nd4 180 25 . . . cord-009571-mygj2nd4 181 1 The the DT cord-009571-mygj2nd4 181 2 mean mean JJ cord-009571-mygj2nd4 181 3 age age NN cord-009571-mygj2nd4 181 4 in in IN cord-009571-mygj2nd4 181 5 patients patient NNS cord-009571-mygj2nd4 181 6 with with IN cord-009571-mygj2nd4 181 7 a a DT cord-009571-mygj2nd4 181 8 positive positive JJ cord-009571-mygj2nd4 181 9 test test NN cord-009571-mygj2nd4 181 10 was be VBD cord-009571-mygj2nd4 181 11 53.1 53.1 CD cord-009571-mygj2nd4 181 12 years year NNS cord-009571-mygj2nd4 181 13 and and CC cord-009571-mygj2nd4 181 14 53.3 53.3 CD cord-009571-mygj2nd4 181 15 years year NNS cord-009571-mygj2nd4 181 16 for for IN cord-009571-mygj2nd4 181 17 those those DT cord-009571-mygj2nd4 181 18 who who WP cord-009571-mygj2nd4 181 19 were be VBD cord-009571-mygj2nd4 181 20 negative negative JJ cord-009571-mygj2nd4 181 21 . . . cord-009571-mygj2nd4 182 1 In in IN cord-009571-mygj2nd4 182 2 contrast contrast NN cord-009571-mygj2nd4 182 3 to to IN cord-009571-mygj2nd4 182 4 these these DT cord-009571-mygj2nd4 182 5 negative negative JJ cord-009571-mygj2nd4 182 6 associations association NNS cord-009571-mygj2nd4 182 7 , , , cord-009571-mygj2nd4 182 8 evidence evidence NN cord-009571-mygj2nd4 182 9 of of IN cord-009571-mygj2nd4 182 10 liver liver NN cord-009571-mygj2nd4 182 11 disease disease NN cord-009571-mygj2nd4 182 12 was be VBD cord-009571-mygj2nd4 182 13 correlated correlate VBN cord-009571-mygj2nd4 182 14 with with IN cord-009571-mygj2nd4 182 15 the the DT cord-009571-mygj2nd4 182 16 finding finding NN cord-009571-mygj2nd4 182 17 of of IN cord-009571-mygj2nd4 182 18 a a DT cord-009571-mygj2nd4 182 19 + + FW cord-009571-mygj2nd4 182 20 RA ra NN cord-009571-mygj2nd4 182 21 latex latex NN cord-009571-mygj2nd4 182 22 . . . cord-009571-mygj2nd4 183 1 Fifty fifty CD cord-009571-mygj2nd4 183 2 percent percent NN cord-009571-mygj2nd4 183 3 of of IN cord-009571-mygj2nd4 183 4 patients patient NNS cord-009571-mygj2nd4 183 5 with with IN cord-009571-mygj2nd4 183 6 liver liver NN cord-009571-mygj2nd4 183 7 disease disease NN cord-009571-mygj2nd4 183 8 had have VBD cord-009571-mygj2nd4 183 9 a a DT cord-009571-mygj2nd4 183 10 + + `` cord-009571-mygj2nd4 183 11 RA ra NN cord-009571-mygj2nd4 183 12 latex latex NN cord-009571-mygj2nd4 183 13 whereas whereas IN cord-009571-mygj2nd4 183 14 it -PRON- PRP cord-009571-mygj2nd4 183 15 was be VBD cord-009571-mygj2nd4 183 16 absent absent JJ cord-009571-mygj2nd4 183 17 in in IN cord-009571-mygj2nd4 183 18 all all DT cord-009571-mygj2nd4 183 19 8 8 CD cord-009571-mygj2nd4 183 20 without without IN cord-009571-mygj2nd4 183 21 liver liver NN cord-009571-mygj2nd4 183 22 disease disease NN cord-009571-mygj2nd4 183 23 . . . cord-009571-mygj2nd4 184 1 We -PRON- PRP cord-009571-mygj2nd4 184 2 conclude conclude VBP cord-009571-mygj2nd4 184 3 that that IN cord-009571-mygj2nd4 184 4 chronic chronic JJ cord-009571-mygj2nd4 184 5 synovitis synovitis NN cord-009571-mygj2nd4 184 6 and and CC cord-009571-mygj2nd4 184 7 polyarticular polyarticular JJ cord-009571-mygj2nd4 184 8 arthritis arthritis NN cord-009571-mygj2nd4 184 9 are be VBP cord-009571-mygj2nd4 184 10 common common JJ cord-009571-mygj2nd4 184 11 in in IN cord-009571-mygj2nd4 184 12 our -PRON- PRP$ cord-009571-mygj2nd4 184 13 gouty gouty JJ cord-009571-mygj2nd4 184 14 patients patient NNS cord-009571-mygj2nd4 184 15 . . . cord-009571-mygj2nd4 185 1 In in IN cord-009571-mygj2nd4 185 2 addition addition NN cord-009571-mygj2nd4 185 3 , , , cord-009571-mygj2nd4 185 4 rheumatoid rheumatoid NN cord-009571-mygj2nd4 185 5 factor factor NN cord-009571-mygj2nd4 185 6 is be VBZ cord-009571-mygj2nd4 185 7 found find VBN cord-009571-mygj2nd4 185 8 in in IN cord-009571-mygj2nd4 185 9 a a DT cord-009571-mygj2nd4 185 10 significant significant JJ cord-009571-mygj2nd4 185 11 proportion proportion NN cord-009571-mygj2nd4 185 12 of of IN cord-009571-mygj2nd4 185 13 gouty gouty JJ cord-009571-mygj2nd4 185 14 patients patient NNS cord-009571-mygj2nd4 185 15 and and CC cord-009571-mygj2nd4 185 16 it -PRON- PRP cord-009571-mygj2nd4 185 17 does do VBZ cord-009571-mygj2nd4 185 18 not not RB cord-009571-mygj2nd4 185 19 seem seem VB cord-009571-mygj2nd4 185 20 to to TO cord-009571-mygj2nd4 185 21 correlate correlate VB cord-009571-mygj2nd4 185 22 with with IN cord-009571-mygj2nd4 185 23 age age NN cord-009571-mygj2nd4 185 24 , , , cord-009571-mygj2nd4 185 25 tophi tophi NNP cord-009571-mygj2nd4 185 26 , , , cord-009571-mygj2nd4 185 27 or or CC cord-009571-mygj2nd4 185 28 chronic chronic JJ cord-009571-mygj2nd4 185 29 synovitis synovitis NN cord-009571-mygj2nd4 185 30 . . . cord-009571-mygj2nd4 186 1 RA RA NNP cord-009571-mygj2nd4 186 2 latex latex NN cord-009571-mygj2nd4 186 3 seems seem VBZ cord-009571-mygj2nd4 186 4 to to TO cord-009571-mygj2nd4 186 5 correlate correlate VB cord-009571-mygj2nd4 186 6 best good JJS cord-009571-mygj2nd4 186 7 with with IN cord-009571-mygj2nd4 186 8 the the DT cord-009571-mygj2nd4 186 9 presence presence NN cord-009571-mygj2nd4 186 10 of of IN cord-009571-mygj2nd4 186 11 liver liver NN cord-009571-mygj2nd4 186 12 disease disease NN cord-009571-mygj2nd4 186 13 which which WDT cord-009571-mygj2nd4 186 14 in in IN cord-009571-mygj2nd4 186 15 most most JJS cord-009571-mygj2nd4 186 16 instances instance NNS cord-009571-mygj2nd4 186 17 was be VBD cord-009571-mygj2nd4 186 18 a a DT cord-009571-mygj2nd4 186 19 concomitant concomitant NN cord-009571-mygj2nd4 186 20 of of IN cord-009571-mygj2nd4 186 21 chronic chronic JJ cord-009571-mygj2nd4 186 22 ethanol ethanol NN cord-009571-mygj2nd4 186 23 abuse abuse NN cord-009571-mygj2nd4 186 24 . . . cord-009571-mygj2nd4 187 1 A a DT cord-009571-mygj2nd4 187 2 polysaccharide polysaccharide NN cord-009571-mygj2nd4 187 3 iden iden NNP cord-009571-mygj2nd4 187 4 tical tical NNP cord-009571-mygj2nd4 187 5 to to IN cord-009571-mygj2nd4 187 6 a a DT cord-009571-mygj2nd4 187 7 Proprionibacterium Proprionibacterium NNP cord-009571-mygj2nd4 187 8 acnes acnes NN cord-009571-mygj2nd4 187 9 polysaccharide polysaccharide NN cord-009571-mygj2nd4 187 10 ( ( -LRB- cord-009571-mygj2nd4 187 11 PPS PPS NNP cord-009571-mygj2nd4 187 12 ) ) -RRB- cord-009571-mygj2nd4 187 13 has have VBZ cord-009571-mygj2nd4 187 14 been be VBN cord-009571-mygj2nd4 187 15 isolated isolate VBN cord-009571-mygj2nd4 187 16 from from IN cord-009571-mygj2nd4 187 17 hyaluronidase hyaluronidase NN cord-009571-mygj2nd4 187 18 treated treat VBN cord-009571-mygj2nd4 187 19 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 187 20 synovial synovial JJ cord-009571-mygj2nd4 187 21 fluids fluid NNS cord-009571-mygj2nd4 187 22 and and CC cord-009571-mygj2nd4 187 23 synovial synovial JJ cord-009571-mygj2nd4 187 24 leukocyte leukocyte NN cord-009571-mygj2nd4 187 25 pellets pellet NNS cord-009571-mygj2nd4 187 26 using use VBG cord-009571-mygj2nd4 187 27 a a DT cord-009571-mygj2nd4 187 28 phenol phenol NN cord-009571-mygj2nd4 187 29 - - HYPH cord-009571-mygj2nd4 187 30 water water NN cord-009571-mygj2nd4 187 31 ( ( -LRB- cord-009571-mygj2nd4 187 32 Westphal Westphal NNP cord-009571-mygj2nd4 187 33 ) ) -RRB- cord-009571-mygj2nd4 187 34 extraction extraction NN cord-009571-mygj2nd4 187 35 and and CC cord-009571-mygj2nd4 187 36 Sepharose Sepharose NNP cord-009571-mygj2nd4 187 37 4B 4b NN cord-009571-mygj2nd4 187 38 column column NN cord-009571-mygj2nd4 187 39 chromatography chromatography NN cord-009571-mygj2nd4 187 40 . . . cord-009571-mygj2nd4 188 1 PPS PPS NNP cord-009571-mygj2nd4 188 2 was be VBD cord-009571-mygj2nd4 188 3 identified identify VBN cord-009571-mygj2nd4 188 4 by by IN cord-009571-mygj2nd4 188 5 counterimmunoelectrophoresis counterimmunoelectrophoresis NNP cord-009571-mygj2nd4 188 6 ( ( -LRB- cord-009571-mygj2nd4 188 7 CIE CIE NNP cord-009571-mygj2nd4 188 8 ) ) -RRB- cord-009571-mygj2nd4 188 9 by by IN cord-009571-mygj2nd4 188 10 rabbit rabbit NN cord-009571-mygj2nd4 188 11 antibody antibody NN cord-009571-mygj2nd4 188 12 to to IN cord-009571-mygj2nd4 188 13 sonicated sonicated NNP cord-009571-mygj2nd4 188 14 P p NN cord-009571-mygj2nd4 188 15 acnes acne NNS cord-009571-mygj2nd4 188 16 organisms organism NNS cord-009571-mygj2nd4 188 17 . . . cord-009571-mygj2nd4 189 1 Sensitivity sensitivity NN cord-009571-mygj2nd4 189 2 by by IN cord-009571-mygj2nd4 189 3 this this DT cord-009571-mygj2nd4 189 4 method method NN cord-009571-mygj2nd4 189 5 is be VBZ cord-009571-mygj2nd4 189 6 approximately approximately RB cord-009571-mygj2nd4 189 7 3.5 3.5 CD cord-009571-mygj2nd4 189 8 ng ng NN cord-009571-mygj2nd4 189 9 of of IN cord-009571-mygj2nd4 189 10 PPS pps NN cord-009571-mygj2nd4 189 11 and and CC cord-009571-mygj2nd4 189 12 identity identity NN cord-009571-mygj2nd4 189 13 of of IN cord-009571-mygj2nd4 189 14 synovial synovial JJ cord-009571-mygj2nd4 189 15 and and CC cord-009571-mygj2nd4 189 16 bacterial bacterial JJ cord-009571-mygj2nd4 189 17 PPS pps NN cord-009571-mygj2nd4 189 18 was be VBD cord-009571-mygj2nd4 189 19 shown show VBN cord-009571-mygj2nd4 189 20 by by IN cord-009571-mygj2nd4 189 21 CIE CIE NNP cord-009571-mygj2nd4 189 22 . . . cord-009571-mygj2nd4 190 1 Of of IN cord-009571-mygj2nd4 190 2 common common JJ cord-009571-mygj2nd4 190 3 aerobic aerobic JJ cord-009571-mygj2nd4 190 4 and and CC cord-009571-mygj2nd4 190 5 anaerobic anaerobic JJ cord-009571-mygj2nd4 190 6 bacteria bacteria NNS cord-009571-mygj2nd4 190 7 tested test VBN cord-009571-mygj2nd4 190 8 , , , cord-009571-mygj2nd4 190 9 only only RB cord-009571-mygj2nd4 190 10 Ps Ps NNP cord-009571-mygj2nd4 190 11 aeruginosa aeruginosa NN cord-009571-mygj2nd4 190 12 contained contain VBD cord-009571-mygj2nd4 190 13 a a DT cord-009571-mygj2nd4 190 14 similar similar JJ cord-009571-mygj2nd4 190 15 antigen antigen NN cord-009571-mygj2nd4 190 16 . . . cord-009571-mygj2nd4 191 1 PPS PPS NNP cord-009571-mygj2nd4 191 2 is be VBZ cord-009571-mygj2nd4 191 3 not not RB cord-009571-mygj2nd4 191 4 present present JJ cord-009571-mygj2nd4 191 5 in in IN cord-009571-mygj2nd4 191 6 E e NN cord-009571-mygj2nd4 191 7 coli coli NNS cord-009571-mygj2nd4 191 8 or or CC cord-009571-mygj2nd4 191 9 S s NN cord-009571-mygj2nd4 191 10 typhosa typhosa NN cord-009571-mygj2nd4 191 11 lipopolysaccharide lipopolysaccharide NN cord-009571-mygj2nd4 191 12 . . . cord-009571-mygj2nd4 192 1 PPS PPS NNP cord-009571-mygj2nd4 192 2 could could MD cord-009571-mygj2nd4 192 3 not not RB cord-009571-mygj2nd4 192 4 be be VB cord-009571-mygj2nd4 192 5 identified identify VBN cord-009571-mygj2nd4 192 6 in in IN cord-009571-mygj2nd4 192 7 synovial synovial JJ cord-009571-mygj2nd4 192 8 fluid fluid NN cord-009571-mygj2nd4 192 9 without without IN cord-009571-mygj2nd4 192 10 extraction extraction NN cord-009571-mygj2nd4 192 11 procedures procedure NNS cord-009571-mygj2nd4 192 12 even even RB cord-009571-mygj2nd4 192 13 when when WRB cord-009571-mygj2nd4 192 14 a a DT cord-009571-mygj2nd4 192 15 more more RBR cord-009571-mygj2nd4 192 16 sensitive sensitive JJ cord-009571-mygj2nd4 192 17 radioimmunoassay radioimmunoassay NN cord-009571-mygj2nd4 192 18 with with IN cord-009571-mygj2nd4 192 19 lZsI lZsI NNP cord-009571-mygj2nd4 192 20 labeled label VBN cord-009571-mygj2nd4 192 21 rabbit rabbit NN cord-009571-mygj2nd4 192 22 antibody antibody NN cord-009571-mygj2nd4 192 23 was be VBD cord-009571-mygj2nd4 192 24 used use VBN cord-009571-mygj2nd4 192 25 . . . cord-009571-mygj2nd4 193 1 Sixty sixty CD cord-009571-mygj2nd4 193 2 percent percent NN cord-009571-mygj2nd4 193 3 of of IN cord-009571-mygj2nd4 193 4 35 35 CD cord-009571-mygj2nd4 193 5 rheumatoid rheumatoid NN cord-009571-mygj2nd4 193 6 fluids fluid NNS cord-009571-mygj2nd4 193 7 and and CC cord-009571-mygj2nd4 193 8 70 70 CD cord-009571-mygj2nd4 193 9 % % NN cord-009571-mygj2nd4 193 10 of of IN cord-009571-mygj2nd4 193 11 10 10 CD cord-009571-mygj2nd4 193 12 rheuma rheuma NNP cord-009571-mygj2nd4 193 13 - - HYPH cord-009571-mygj2nd4 193 14 toid toid JJ cord-009571-mygj2nd4 193 15 synovial synovial JJ cord-009571-mygj2nd4 193 16 leukocyte leukocyte NN cord-009571-mygj2nd4 193 17 pellets pellet NNS cord-009571-mygj2nd4 193 18 contained contain VBD cord-009571-mygj2nd4 193 19 PPS PPS NNP cord-009571-mygj2nd4 193 20 . . . cord-009571-mygj2nd4 194 1 Only only RB cord-009571-mygj2nd4 194 2 1 1 CD cord-009571-mygj2nd4 194 3 of of IN cord-009571-mygj2nd4 194 4 16 16 CD cord-009571-mygj2nd4 194 5 ( ( -LRB- cord-009571-mygj2nd4 194 6 6 6 CD cord-009571-mygj2nd4 194 7 % % NN cord-009571-mygj2nd4 194 8 ) ) -RRB- cord-009571-mygj2nd4 195 1 nonrheumatoid nonrheumatoid NNP cord-009571-mygj2nd4 195 2 fluids fluid NNS cord-009571-mygj2nd4 195 3 was be VBD cord-009571-mygj2nd4 195 4 positive positive JJ cord-009571-mygj2nd4 195 5 . . . cord-009571-mygj2nd4 196 1 Two two CD cord-009571-mygj2nd4 196 2 of of IN cord-009571-mygj2nd4 196 3 9 9 CD cord-009571-mygj2nd4 196 4 ( ( -LRB- cord-009571-mygj2nd4 196 5 23 23 CD cord-009571-mygj2nd4 196 6 % % NN cord-009571-mygj2nd4 196 7 ) ) -RRB- cord-009571-mygj2nd4 197 1 nonrheumatoid nonrheumatoid NNP cord-009571-mygj2nd4 197 2 inflammatory inflammatory JJ cord-009571-mygj2nd4 197 3 synovial synovial JJ cord-009571-mygj2nd4 197 4 leukocyte leukocyte NN cord-009571-mygj2nd4 197 5 pellets pellet NNS cord-009571-mygj2nd4 197 6 contained contain VBD cord-009571-mygj2nd4 197 7 PPS PPS NNP cord-009571-mygj2nd4 197 8 . . . cord-009571-mygj2nd4 198 1 Antibody antibody NN cord-009571-mygj2nd4 198 2 to to IN cord-009571-mygj2nd4 198 3 PPS PPS NNP cord-009571-mygj2nd4 198 4 by by IN cord-009571-mygj2nd4 198 5 CIE CIE NNP cord-009571-mygj2nd4 198 6 was be VBD cord-009571-mygj2nd4 198 7 found find VBN cord-009571-mygj2nd4 198 8 in in IN cord-009571-mygj2nd4 198 9 33 33 CD cord-009571-mygj2nd4 198 10 % % NN cord-009571-mygj2nd4 198 11 of of IN cord-009571-mygj2nd4 198 12 rheumatoid rheumatoid NNP cord-009571-mygj2nd4 198 13 sera sera NNP cord-009571-mygj2nd4 199 1 ( ( -LRB- cord-009571-mygj2nd4 199 2 P p NN cord-009571-mygj2nd4 199 3 < < XX cord-009571-mygj2nd4 199 4 0.01 0.01 CD cord-009571-mygj2nd4 199 5 ) ) -RRB- cord-009571-mygj2nd4 199 6 , , , cord-009571-mygj2nd4 199 7 45 45 CD cord-009571-mygj2nd4 199 8 % % NN cord-009571-mygj2nd4 199 9 of of IN cord-009571-mygj2nd4 199 10 nonrheumatoid nonrheumatoid JJ cord-009571-mygj2nd4 199 11 inflammatory inflammatory JJ cord-009571-mygj2nd4 199 12 arthritic arthritic JJ cord-009571-mygj2nd4 199 13 sera sera NNP cord-009571-mygj2nd4 199 14 ( ( -LRB- cord-009571-mygj2nd4 199 15 P p NN cord-009571-mygj2nd4 199 16 < < XX cord-009571-mygj2nd4 199 17 0.05 0.05 CD cord-009571-mygj2nd4 199 18 ) ) -RRB- cord-009571-mygj2nd4 199 19 , , , cord-009571-mygj2nd4 199 20 and and CC cord-009571-mygj2nd4 199 21 67 67 CD cord-009571-mygj2nd4 199 22 % % NN cord-009571-mygj2nd4 199 23 of of IN cord-009571-mygj2nd4 199 24 normal normal JJ cord-009571-mygj2nd4 199 25 control control NN cord-009571-mygj2nd4 199 26 sera sera NNP cord-009571-mygj2nd4 199 27 . . . cord-009571-mygj2nd4 200 1 Characteristics characteristic NNS cord-009571-mygj2nd4 200 2 of of IN cord-009571-mygj2nd4 200 3 PPS PPS NNP cord-009571-mygj2nd4 200 4 ( ( -LRB- cord-009571-mygj2nd4 200 5 bacterial bacterial JJ cord-009571-mygj2nd4 200 6 and and CC cord-009571-mygj2nd4 200 7 synovial synovial JJ cord-009571-mygj2nd4 200 8 ) ) -RRB- cord-009571-mygj2nd4 200 9 include include VBP cord-009571-mygj2nd4 200 10 sensitivity sensitivity NN cord-009571-mygj2nd4 200 11 to to IN cord-009571-mygj2nd4 200 12 50 50 CD cord-009571-mygj2nd4 200 13 mM mm CD cord-009571-mygj2nd4 200 14 periodate periodate NN cord-009571-mygj2nd4 200 15 oxidation oxidation NN cord-009571-mygj2nd4 200 16 , , , cord-009571-mygj2nd4 200 17 resistance resistance NN cord-009571-mygj2nd4 200 18 to to IN cord-009571-mygj2nd4 200 19 RNase RNase NNP cord-009571-mygj2nd4 200 20 , , , cord-009571-mygj2nd4 200 21 DNase DNase NNP cord-009571-mygj2nd4 200 22 , , , cord-009571-mygj2nd4 200 23 pronase pronase NN cord-009571-mygj2nd4 200 24 , , , cord-009571-mygj2nd4 200 25 and and CC cord-009571-mygj2nd4 200 26 boiling boiling NN cord-009571-mygj2nd4 200 27 . . . cord-009571-mygj2nd4 201 1 Uronic uronic JJ cord-009571-mygj2nd4 201 2 acid acid NN cord-009571-mygj2nd4 201 3 and and CC cord-009571-mygj2nd4 201 4 hexosamine hexosamine NN cord-009571-mygj2nd4 201 5 account account VBP cord-009571-mygj2nd4 201 6 for for IN cord-009571-mygj2nd4 201 7 approximately approximately RB cord-009571-mygj2nd4 201 8 50 50 CD cord-009571-mygj2nd4 201 9 % % NN cord-009571-mygj2nd4 201 10 by by IN cord-009571-mygj2nd4 201 11 weight weight NN cord-009571-mygj2nd4 201 12 . . . cord-009571-mygj2nd4 202 1 Less Less JJR cord-009571-mygj2nd4 202 2 than than IN cord-009571-mygj2nd4 202 3 0.5 0.5 CD cord-009571-mygj2nd4 202 4 % % NN cord-009571-mygj2nd4 202 5 protein protein NN cord-009571-mygj2nd4 202 6 is be VBZ cord-009571-mygj2nd4 202 7 present present JJ cord-009571-mygj2nd4 202 8 . . . cord-009571-mygj2nd4 203 1 It -PRON- PRP cord-009571-mygj2nd4 203 2 appears appear VBZ cord-009571-mygj2nd4 203 3 polydisperse polydisperse JJ cord-009571-mygj2nd4 203 4 on on IN cord-009571-mygj2nd4 203 5 Sephadex Sephadex NNP cord-009571-mygj2nd4 203 6 G200 G200 NNP cord-009571-mygj2nd4 203 7 with with IN cord-009571-mygj2nd4 203 8 a a DT cord-009571-mygj2nd4 203 9 M M NNP cord-009571-mygj2nd4 203 10 W W NNP cord-009571-mygj2nd4 203 11 of of IN cord-009571-mygj2nd4 203 12 approximately approximately RB cord-009571-mygj2nd4 203 13 5 5 CD cord-009571-mygj2nd4 203 14 X x NN cord-009571-mygj2nd4 203 15 1 1 CD cord-009571-mygj2nd4 203 16 0 0 CD cord-009571-mygj2nd4 203 17 ' ' '' cord-009571-mygj2nd4 203 18 to to IN cord-009571-mygj2nd4 203 19 > > XX cord-009571-mygj2nd4 203 20 lP. lP. NNP cord-009571-mygj2nd4 203 21 Electrophoresis Electrophoresis NNP cord-009571-mygj2nd4 203 22 in in IN cord-009571-mygj2nd4 203 23 3.5 3.5 CD cord-009571-mygj2nd4 203 24 % % NN cord-009571-mygj2nd4 203 25 polyacrylamide polyacrylamide NN cord-009571-mygj2nd4 203 26 showed show VBD cord-009571-mygj2nd4 203 27 a a DT cord-009571-mygj2nd4 203 28 single single JJ cord-009571-mygj2nd4 203 29 PAS pas NN cord-009571-mygj2nd4 203 30 positive positive JJ cord-009571-mygj2nd4 203 31 band band NN cord-009571-mygj2nd4 203 32 which which WDT cord-009571-mygj2nd4 203 33 formed form VBD cord-009571-mygj2nd4 203 34 a a DT cord-009571-mygj2nd4 203 35 preciptin preciptin NN cord-009571-mygj2nd4 203 36 line line NN cord-009571-mygj2nd4 203 37 with with IN cord-009571-mygj2nd4 203 38 anti anti JJ cord-009571-mygj2nd4 203 39 - - JJ cord-009571-mygj2nd4 203 40 P p JJ cord-009571-mygj2nd4 203 41 acnes acne NNS cord-009571-mygj2nd4 203 42 antibody antibody NN cord-009571-mygj2nd4 203 43 by by IN cord-009571-mygj2nd4 203 44 crossed cross VBN cord-009571-mygj2nd4 203 45 CIE CIE NNP cord-009571-mygj2nd4 203 46 . . . cord-009571-mygj2nd4 204 1 No no DT cord-009571-mygj2nd4 204 2 lipid lipid NN cord-009571-mygj2nd4 204 3 staining stain VBG cord-009571-mygj2nd4 204 4 bands band NNS cord-009571-mygj2nd4 204 5 were be VBD cord-009571-mygj2nd4 204 6 noted note VBN cord-009571-mygj2nd4 204 7 . . . cord-009571-mygj2nd4 205 1 These these DT cord-009571-mygj2nd4 205 2 findings finding NNS cord-009571-mygj2nd4 205 3 are be VBP cord-009571-mygj2nd4 205 4 consistent consistent JJ cord-009571-mygj2nd4 205 5 with with IN cord-009571-mygj2nd4 205 6 a a DT cord-009571-mygj2nd4 205 7 polysaccharide polysaccharide NN cord-009571-mygj2nd4 205 8 antigen antigen NN cord-009571-mygj2nd4 205 9 . . . cord-009571-mygj2nd4 206 1 The the DT cord-009571-mygj2nd4 206 2 isolation isolation NN cord-009571-mygj2nd4 206 3 of of IN cord-009571-mygj2nd4 206 4 a a DT cord-009571-mygj2nd4 206 5 bound bind VBN cord-009571-mygj2nd4 206 6 antigenic antigenic JJ cord-009571-mygj2nd4 206 7 bacterial bacterial JJ cord-009571-mygj2nd4 206 8 polysaccharide polysaccharide NN cord-009571-mygj2nd4 206 9 primarily primarily RB cord-009571-mygj2nd4 206 10 from from IN cord-009571-mygj2nd4 206 11 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 206 12 effusions effusion NNS cord-009571-mygj2nd4 206 13 associated associate VBN cord-009571-mygj2nd4 206 14 with with IN cord-009571-mygj2nd4 206 15 diminished diminished JJ cord-009571-mygj2nd4 206 16 antibody antibody NN cord-009571-mygj2nd4 206 17 suggests suggest VBZ cord-009571-mygj2nd4 206 18 a a DT cord-009571-mygj2nd4 206 19 pathogenetic pathogenetic JJ cord-009571-mygj2nd4 206 20 role role NN cord-009571-mygj2nd4 206 21 for for IN cord-009571-mygj2nd4 206 22 PPS PPS NNP cord-009571-mygj2nd4 206 23 in in IN cord-009571-mygj2nd4 206 24 rheumatoid rheumatoid NN cord-009571-mygj2nd4 206 25 arthritis arthritis NN cord-009571-mygj2nd4 206 26 possibly possibly RB cord-009571-mygj2nd4 206 27 as as IN cord-009571-mygj2nd4 206 28 an an DT cord-009571-mygj2nd4 206 29 immune immune JJ cord-009571-mygj2nd4 206 30 complex complex JJ cord-009571-mygj2nd4 206 31 type type NN cord-009571-mygj2nd4 206 32 . . . cord-009571-mygj2nd4 207 1 An an DT cord-009571-mygj2nd4 207 2 in in FW cord-009571-mygj2nd4 207 3 vitro vitro FW cord-009571-mygj2nd4 207 4 system system NN cord-009571-mygj2nd4 207 5 for for IN cord-009571-mygj2nd4 207 6 examining examine VBG cord-009571-mygj2nd4 207 7 the the DT cord-009571-mygj2nd4 207 8 cellular cellular JJ cord-009571-mygj2nd4 207 9 requirements requirement NNS cord-009571-mygj2nd4 207 10 necessary necessary JJ cord-009571-mygj2nd4 207 11 for for IN cord-009571-mygj2nd4 207 12 initiating initiate VBG cord-009571-mygj2nd4 207 13 and and CC cord-009571-mygj2nd4 207 14 regulating regulate VBG cord-009571-mygj2nd4 207 15 antinucleic antinucleic JJ cord-009571-mygj2nd4 207 16 acid acid NN cord-009571-mygj2nd4 207 17 antibody antibody NN cord-009571-mygj2nd4 207 18 responses response NNS cord-009571-mygj2nd4 207 19 has have VBZ cord-009571-mygj2nd4 207 20 been be VBN cord-009571-mygj2nd4 207 21 developed develop VBN cord-009571-mygj2nd4 207 22 to to TO cord-009571-mygj2nd4 207 23 facilitate facilitate VB cord-009571-mygj2nd4 207 24 a a DT cord-009571-mygj2nd4 207 25 better well JJR cord-009571-mygj2nd4 207 26 understanding understanding NN cord-009571-mygj2nd4 207 27 of of IN cord-009571-mygj2nd4 207 28 the the DT cord-009571-mygj2nd4 207 29 mechanisms mechanism NNS cord-009571-mygj2nd4 207 30 responsible responsible JJ cord-009571-mygj2nd4 207 31 for for IN cord-009571-mygj2nd4 207 32 triggering trigger VBG cord-009571-mygj2nd4 207 33 antibody antibody NN cord-009571-mygj2nd4 207 34 responses response NNS cord-009571-mygj2nd4 207 35 to to IN cord-009571-mygj2nd4 207 36 this this DT cord-009571-mygj2nd4 207 37 group group NN cord-009571-mygj2nd4 207 38 of of IN cord-009571-mygj2nd4 207 39 antigens antigen NNS cord-009571-mygj2nd4 207 40 in in IN cord-009571-mygj2nd4 207 41 murine murine JJ cord-009571-mygj2nd4 207 42 and and CC cord-009571-mygj2nd4 207 43 human human JJ cord-009571-mygj2nd4 207 44 SLE sle NN cord-009571-mygj2nd4 207 45 . . . cord-009571-mygj2nd4 208 1 It -PRON- PRP cord-009571-mygj2nd4 208 2 has have VBZ cord-009571-mygj2nd4 208 3 been be VBN cord-009571-mygj2nd4 208 4 found find VBN cord-009571-mygj2nd4 208 5 that that IN cord-009571-mygj2nd4 208 6 spontaneously spontaneously RB cord-009571-mygj2nd4 208 7 appearing appear VBG cord-009571-mygj2nd4 208 8 anti anti JJ cord-009571-mygj2nd4 208 9 - - JJ cord-009571-mygj2nd4 208 10 ssDNA ssdna JJ cord-009571-mygj2nd4 208 11 hemolytic hemolytic JJ cord-009571-mygj2nd4 208 12 plaque plaque NN cord-009571-mygj2nd4 208 13 forming form VBG cord-009571-mygj2nd4 208 14 cells cell NNS cord-009571-mygj2nd4 208 15 ( ( -LRB- cord-009571-mygj2nd4 208 16 PFC PFC NNP cord-009571-mygj2nd4 208 17 ) ) -RRB- cord-009571-mygj2nd4 208 18 can can MD cord-009571-mygj2nd4 208 19 be be VB cord-009571-mygj2nd4 208 20 detected detect VBN cord-009571-mygj2nd4 208 21 when when WRB cord-009571-mygj2nd4 208 22 spleen spleen NN cord-009571-mygj2nd4 208 23 cells cell NNS cord-009571-mygj2nd4 208 24 from from IN cord-009571-mygj2nd4 208 25 normal normal JJ cord-009571-mygj2nd4 208 26 mice mouse NNS cord-009571-mygj2nd4 208 27 of of IN cord-009571-mygj2nd4 208 28 different different JJ cord-009571-mygj2nd4 208 29 Hz Hz NNP cord-009571-mygj2nd4 208 30 types type NNS cord-009571-mygj2nd4 208 31 ( ( -LRB- cord-009571-mygj2nd4 208 32 CBA CBA NNP cord-009571-mygj2nd4 208 33 , , , cord-009571-mygj2nd4 208 34 DBA DBA NNP cord-009571-mygj2nd4 208 35 , , , cord-009571-mygj2nd4 208 36 BDF1 BDF1 NNP cord-009571-mygj2nd4 208 37 , , , cord-009571-mygj2nd4 208 38 CFW CFW NNP cord-009571-mygj2nd4 208 39 , , , cord-009571-mygj2nd4 208 40 C57 C57 NNP cord-009571-mygj2nd4 208 41 / / SYM cord-009571-mygj2nd4 208 42 B16 B16 NNP cord-009571-mygj2nd4 208 43 ) ) -RRB- cord-009571-mygj2nd4 208 44 or or CC cord-009571-mygj2nd4 208 45 young young JJ cord-009571-mygj2nd4 208 46 ( ( -LRB- cord-009571-mygj2nd4 208 47 4 4 CD cord-009571-mygj2nd4 208 48 weeks week NNS cord-009571-mygj2nd4 208 49 ) ) -RRB- cord-009571-mygj2nd4 209 1 autoimmune autoimmune NNP cord-009571-mygj2nd4 210 1 ( ( -LRB- cord-009571-mygj2nd4 210 2 NZB NZB NNP cord-009571-mygj2nd4 210 3 X X NNP cord-009571-mygj2nd4 210 4 NZW NZW NNP cord-009571-mygj2nd4 210 5 F1 f1 NN cord-009571-mygj2nd4 210 6 ( ( -LRB- cord-009571-mygj2nd4 210 7 B B NNP cord-009571-mygj2nd4 210 8 / / SYM cord-009571-mygj2nd4 210 9 W W NNP cord-009571-mygj2nd4 210 10 ) ) -RRB- cord-009571-mygj2nd4 210 11 , , , cord-009571-mygj2nd4 210 12 NZB NZB NNP cord-009571-mygj2nd4 210 13 , , , cord-009571-mygj2nd4 210 14 NZW NZW NNP cord-009571-mygj2nd4 210 15 ) ) -RRB- cord-009571-mygj2nd4 210 16 strains strain NNS cord-009571-mygj2nd4 210 17 of of IN cord-009571-mygj2nd4 210 18 mice mouse NNS cord-009571-mygj2nd4 210 19 are be VBP cord-009571-mygj2nd4 210 20 cultured culture VBN cord-009571-mygj2nd4 210 21 under under IN cord-009571-mygj2nd4 210 22 standard standard JJ cord-009571-mygj2nd4 210 23 Mishell Mishell NNP cord-009571-mygj2nd4 210 24 Dutton Dutton NNP cord-009571-mygj2nd4 210 25 conditions condition NNS cord-009571-mygj2nd4 210 26 in in IN cord-009571-mygj2nd4 210 27 the the DT cord-009571-mygj2nd4 210 28 absence absence NN cord-009571-mygj2nd4 210 29 of of IN cord-009571-mygj2nd4 210 30 added add VBN cord-009571-mygj2nd4 210 31 antigen antigen NN cord-009571-mygj2nd4 210 32 . . . cord-009571-mygj2nd4 211 1 Such such JJ cord-009571-mygj2nd4 211 2 PFC(200 pfc(200 NN cord-009571-mygj2nd4 211 3 - - HYPH cord-009571-mygj2nd4 211 4 2600 2600 CD cord-009571-mygj2nd4 211 5 / / SYM cord-009571-mygj2nd4 211 6 culture culture NN cord-009571-mygj2nd4 211 7 ) ) -RRB- cord-009571-mygj2nd4 211 8 which which WDT cord-009571-mygj2nd4 211 9 peak peak NN cord-009571-mygj2nd4 211 10 on on IN cord-009571-mygj2nd4 211 11 day day NN cord-009571-mygj2nd4 211 12 5 5 CD cord-009571-mygj2nd4 211 13 and and CC cord-009571-mygj2nd4 211 14 can can MD cord-009571-mygj2nd4 211 15 not not RB cord-009571-mygj2nd4 211 16 be be VB cord-009571-mygj2nd4 211 17 detected detect VBN cord-009571-mygj2nd4 211 18 prior prior RB cord-009571-mygj2nd4 211 19 to to IN cord-009571-mygj2nd4 211 20 culture culture NN cord-009571-mygj2nd4 211 21 consist consist VBP cord-009571-mygj2nd4 211 22 entirely entirely RB cord-009571-mygj2nd4 211 23 of of IN cord-009571-mygj2nd4 211 24 specific specific JJ cord-009571-mygj2nd4 211 25 IgM IgM NNP cord-009571-mygj2nd4 211 26 anti anti JJ cord-009571-mygj2nd4 211 27 - - JJ cord-009571-mygj2nd4 211 28 ssDNA ssdna JJ cord-009571-mygj2nd4 211 29 antibody antibody NN cord-009571-mygj2nd4 211 30 . . . cord-009571-mygj2nd4 212 1 The the DT cord-009571-mygj2nd4 212 2 response response NN cord-009571-mygj2nd4 212 3 , , , cord-009571-mygj2nd4 212 4 which which WDT cord-009571-mygj2nd4 212 5 appears appear VBZ cord-009571-mygj2nd4 212 6 to to TO cord-009571-mygj2nd4 212 7 be be VB cord-009571-mygj2nd4 212 8 dependent dependent JJ cord-009571-mygj2nd4 212 9 on on IN cord-009571-mygj2nd4 212 10 active active JJ cord-009571-mygj2nd4 212 11 antibody antibody NN cord-009571-mygj2nd4 212 12 synthesis synthesis NN cord-009571-mygj2nd4 212 13 , , , cord-009571-mygj2nd4 212 14 can can MD cord-009571-mygj2nd4 212 15 be be VB cord-009571-mygj2nd4 212 16 selectively selectively RB cord-009571-mygj2nd4 212 17 abolished abolish VBN cord-009571-mygj2nd4 212 18 by by IN cord-009571-mygj2nd4 212 19 specific specific JJ cord-009571-mygj2nd4 212 20 removal removal NN cord-009571-mygj2nd4 212 21 of of IN cord-009571-mygj2nd4 212 22 ssDNA ssdna NN cord-009571-mygj2nd4 212 23 antigen antigen NN cord-009571-mygj2nd4 212 24 binding bind VBG cord-009571-mygj2nd4 212 25 cells cell NNS cord-009571-mygj2nd4 212 26 , , , cord-009571-mygj2nd4 212 27 by by IN cord-009571-mygj2nd4 212 28 rosette rosette NN cord-009571-mygj2nd4 212 29 depletion depletion NN cord-009571-mygj2nd4 212 30 . . . cord-009571-mygj2nd4 213 1 While while IN cord-009571-mygj2nd4 213 2 low low JJ cord-009571-mygj2nd4 213 3 responses response NNS cord-009571-mygj2nd4 213 4 can can MD cord-009571-mygj2nd4 213 5 be be VB cord-009571-mygj2nd4 213 6 augmented augment VBN cord-009571-mygj2nd4 213 7 by by IN cord-009571-mygj2nd4 213 8 pokeweed pokeweed JJ cord-009571-mygj2nd4 213 9 mitogen mitogen NN cord-009571-mygj2nd4 213 10 , , , cord-009571-mygj2nd4 213 11 there there EX cord-009571-mygj2nd4 213 12 is be VBZ cord-009571-mygj2nd4 213 13 no no DT cord-009571-mygj2nd4 213 14 obligatory obligatory JJ cord-009571-mygj2nd4 213 15 requirement requirement NN cord-009571-mygj2nd4 213 16 of of IN cord-009571-mygj2nd4 213 17 serum serum NN cord-009571-mygj2nd4 213 18 , , , cord-009571-mygj2nd4 213 19 thymic thymic JJ cord-009571-mygj2nd4 213 20 ( ( -LRB- cord-009571-mygj2nd4 213 21 T t NN cord-009571-mygj2nd4 213 22 ) ) -RRB- cord-009571-mygj2nd4 213 23 cells cell NNS cord-009571-mygj2nd4 213 24 , , , cord-009571-mygj2nd4 213 25 or or CC cord-009571-mygj2nd4 213 26 macrophages macrophage NNS cord-009571-mygj2nd4 213 27 in in IN cord-009571-mygj2nd4 213 28 the the DT cord-009571-mygj2nd4 213 29 culture culture NN cord-009571-mygj2nd4 213 30 system system NN cord-009571-mygj2nd4 213 31 . . . cord-009571-mygj2nd4 214 1 This this DT cord-009571-mygj2nd4 214 2 in in IN cord-009571-mygj2nd4 214 3 vitro vitro FW cord-009571-mygj2nd4 214 4 response response NN cord-009571-mygj2nd4 214 5 can can MD cord-009571-mygj2nd4 214 6 blocked block VBN cord-009571-mygj2nd4 214 7 by by IN cord-009571-mygj2nd4 214 8 : : : cord-009571-mygj2nd4 214 9 1 1 LS cord-009571-mygj2nd4 214 10 ) ) -RRB- cord-009571-mygj2nd4 214 11 adding add VBG cord-009571-mygj2nd4 214 12 small small JJ cord-009571-mygj2nd4 214 13 quantities quantity NNS cord-009571-mygj2nd4 214 14 of of IN cord-009571-mygj2nd4 214 15 ssDNA ssdna NN cord-009571-mygj2nd4 214 16 ( ( -LRB- cord-009571-mygj2nd4 214 17 lO-5Opg lo-5opg NN cord-009571-mygj2nd4 214 18 ) ) -RRB- cord-009571-mygj2nd4 214 19 but but CC cord-009571-mygj2nd4 214 20 not not RB cord-009571-mygj2nd4 214 21 similar similar JJ cord-009571-mygj2nd4 214 22 concentrations concentration NNS cord-009571-mygj2nd4 214 23 of of IN cord-009571-mygj2nd4 214 24 DNA DNA NNP cord-009571-mygj2nd4 214 25 or or CC cord-009571-mygj2nd4 214 26 RNA RNA NNP cord-009571-mygj2nd4 214 27 directly directly RB cord-009571-mygj2nd4 214 28 to to IN cord-009571-mygj2nd4 214 29 culture culture NN cord-009571-mygj2nd4 214 30 on on IN cord-009571-mygj2nd4 214 31 day day NN cord-009571-mygj2nd4 214 32 1 1 CD cord-009571-mygj2nd4 214 33 ; ; : cord-009571-mygj2nd4 214 34 2 2 LS cord-009571-mygj2nd4 214 35 ) ) -RRB- cord-009571-mygj2nd4 214 36 pre pre JJ cord-009571-mygj2nd4 214 37 - - NN cord-009571-mygj2nd4 214 38 incubation incubation NN cord-009571-mygj2nd4 214 39 of of IN cord-009571-mygj2nd4 214 40 Spleen spleen NN cord-009571-mygj2nd4 214 41 cells cell NNS cord-009571-mygj2nd4 214 42 with with IN cord-009571-mygj2nd4 214 43 ssDNA ssdna NN cord-009571-mygj2nd4 214 44 ( ( -LRB- cord-009571-mygj2nd4 214 45 1 1 CD cord-009571-mygj2nd4 214 46 hour hour NN cord-009571-mygj2nd4 214 47 ) ) -RRB- cord-009571-mygj2nd4 214 48 and and CC cord-009571-mygj2nd4 214 49 washing wash VBG cord-009571-mygj2nd4 214 50 prior prior RB cord-009571-mygj2nd4 214 51 to to IN cord-009571-mygj2nd4 214 52 culture culture NN cord-009571-mygj2nd4 214 53 . . . cord-009571-mygj2nd4 215 1 Unblocking Unblocking NNP cord-009571-mygj2nd4 215 2 can can MD cord-009571-mygj2nd4 215 3 be be VB cord-009571-mygj2nd4 215 4 demonstrated demonstrate VBN cord-009571-mygj2nd4 215 5 by by IN cord-009571-mygj2nd4 215 6 subsequently subsequently RB cord-009571-mygj2nd4 215 7 treating treat VBG cord-009571-mygj2nd4 215 8 these these DT cord-009571-mygj2nd4 215 9 cells cell NNS cord-009571-mygj2nd4 215 10 with with IN cord-009571-mygj2nd4 215 11 trypsin trypsin NN cord-009571-mygj2nd4 215 12 - - HYPH cord-009571-mygj2nd4 215 13 DNAse DNAse NNS cord-009571-mygj2nd4 215 14 , , , cord-009571-mygj2nd4 215 15 suggesting suggest VBG cord-009571-mygj2nd4 215 16 that that IN cord-009571-mygj2nd4 215 17 this this DT cord-009571-mygj2nd4 215 18 inhibition inhibition NN cord-009571-mygj2nd4 215 19 may may MD cord-009571-mygj2nd4 215 20 be be VB cord-009571-mygj2nd4 215 21 due due JJ cord-009571-mygj2nd4 215 22 to to IN cord-009571-mygj2nd4 215 23 a a DT cord-009571-mygj2nd4 215 24 membrane membrane NN cord-009571-mygj2nd4 215 25 receptor receptor NN cord-009571-mygj2nd4 215 26 blockade blockade NN cord-009571-mygj2nd4 215 27 mechanism mechanism NN cord-009571-mygj2nd4 215 28 ; ; : cord-009571-mygj2nd4 215 29 3 3 LS cord-009571-mygj2nd4 215 30 ) ) -RRB- cord-009571-mygj2nd4 215 31 the the DT cord-009571-mygj2nd4 215 32 addition addition NN cord-009571-mygj2nd4 215 33 to to IN cord-009571-mygj2nd4 215 34 young young JJ cord-009571-mygj2nd4 215 35 B B NNP cord-009571-mygj2nd4 215 36 / / SYM cord-009571-mygj2nd4 215 37 W w NN cord-009571-mygj2nd4 215 38 spleen spleen NN cord-009571-mygj2nd4 215 39 cells cell NNS cord-009571-mygj2nd4 215 40 of of IN cord-009571-mygj2nd4 215 41 T t NN cord-009571-mygj2nd4 215 42 cells cell NNS cord-009571-mygj2nd4 215 43 from from IN cord-009571-mygj2nd4 215 44 young young JJ cord-009571-mygj2nd4 215 45 ( ( -LRB- cord-009571-mygj2nd4 215 46 4 4 CD cord-009571-mygj2nd4 215 47 weeks week NNS cord-009571-mygj2nd4 215 48 ) ) -RRB- cord-009571-mygj2nd4 215 49 or or CC cord-009571-mygj2nd4 215 50 old old JJ cord-009571-mygj2nd4 215 51 ( ( -LRB- cord-009571-mygj2nd4 215 52 > > NN cord-009571-mygj2nd4 215 53 6 6 CD cord-009571-mygj2nd4 215 54 months month NNS cord-009571-mygj2nd4 215 55 ) ) -RRB- cord-009571-mygj2nd4 215 56 syngeneic syngeneic NNS cord-009571-mygj2nd4 215 57 mice mouse NNS cord-009571-mygj2nd4 215 58 similarly similarly RB cord-009571-mygj2nd4 215 59 abrogates abrogate VBZ cord-009571-mygj2nd4 215 60 this this DT cord-009571-mygj2nd4 215 61 in in FW cord-009571-mygj2nd4 215 62 vitro vitro FW cord-009571-mygj2nd4 215 63 anti anti JJ cord-009571-mygj2nd4 215 64 - - JJ cord-009571-mygj2nd4 215 65 ssDNA ssdna JJ cord-009571-mygj2nd4 215 66 response response NN cord-009571-mygj2nd4 215 67 without without IN cord-009571-mygj2nd4 215 68 effecting effect VBG cord-009571-mygj2nd4 215 69 cell cell NN cord-009571-mygj2nd4 215 70 viability viability NN cord-009571-mygj2nd4 215 71 or or CC cord-009571-mygj2nd4 215 72 the the DT cord-009571-mygj2nd4 215 73 anti anti JJ cord-009571-mygj2nd4 215 74 - - JJ cord-009571-mygj2nd4 215 75 SRBC SRBC NNP cord-009571-mygj2nd4 215 76 antibody antibody NN cord-009571-mygj2nd4 215 77 response response NN cord-009571-mygj2nd4 215 78 . . . cord-009571-mygj2nd4 216 1 On on IN cord-009571-mygj2nd4 216 2 the the DT cord-009571-mygj2nd4 216 3 other other JJ cord-009571-mygj2nd4 216 4 hand hand NN cord-009571-mygj2nd4 216 5 syngeneic syngeneic NNS cord-009571-mygj2nd4 216 6 bone bone NN cord-009571-mygj2nd4 216 7 marrow marrow NN cord-009571-mygj2nd4 216 8 cells cell NNS cord-009571-mygj2nd4 216 9 which which WDT cord-009571-mygj2nd4 216 10 markedly markedly RB cord-009571-mygj2nd4 216 11 suppress suppress VBP cord-009571-mygj2nd4 216 12 the the DT cord-009571-mygj2nd4 216 13 anti anti JJ cord-009571-mygj2nd4 216 14 - - JJ cord-009571-mygj2nd4 216 15 SRBC SRBC NNP cord-009571-mygj2nd4 216 16 antibody antibody NN cord-009571-mygj2nd4 216 17 response response NN cord-009571-mygj2nd4 216 18 have have VBP cord-009571-mygj2nd4 216 19 no no DT cord-009571-mygj2nd4 216 20 effect effect NN cord-009571-mygj2nd4 216 21 on on IN cord-009571-mygj2nd4 216 22 the the DT cord-009571-mygj2nd4 216 23 anti anti JJ cord-009571-mygj2nd4 216 24 - - JJ cord-009571-mygj2nd4 216 25 ssDNA ssdna JJ cord-009571-mygj2nd4 216 26 response response NN cord-009571-mygj2nd4 216 27 of of IN cord-009571-mygj2nd4 216 28 these these DT cord-009571-mygj2nd4 216 29 spleen spleen NN cord-009571-mygj2nd4 216 30 cells cell NNS cord-009571-mygj2nd4 216 31 . . . cord-009571-mygj2nd4 217 1 These these DT cord-009571-mygj2nd4 217 2 in in IN cord-009571-mygj2nd4 217 3 vitro vitro FW cord-009571-mygj2nd4 217 4 studies study NNS cord-009571-mygj2nd4 217 5 suggest suggest VBP cord-009571-mygj2nd4 217 6 mechanisms mechanism NNS cord-009571-mygj2nd4 217 7 that that WDT cord-009571-mygj2nd4 217 8 may may MD cord-009571-mygj2nd4 217 9 be be VB cord-009571-mygj2nd4 217 10 relevant relevant JJ cord-009571-mygj2nd4 217 11 to to IN cord-009571-mygj2nd4 217 12 the the DT cord-009571-mygj2nd4 217 13 normal normal JJ cord-009571-mygj2nd4 217 14 regulation regulation NN cord-009571-mygj2nd4 217 15 of of IN cord-009571-mygj2nd4 217 16 anti anti JJ cord-009571-mygj2nd4 217 17 - - JJ cord-009571-mygj2nd4 217 18 nucleic nucleic JJ cord-009571-mygj2nd4 217 19 acid acid NN cord-009571-mygj2nd4 217 20 antibody antibody NN cord-009571-mygj2nd4 217 21 and and CC cord-009571-mygj2nd4 217 22 other other JJ cord-009571-mygj2nd4 217 23 autoantibody autoantibody NN cord-009571-mygj2nd4 217 24 responses response NNS cord-009571-mygj2nd4 217 25 in in IN cord-009571-mygj2nd4 217 26 vivo vivo NNP cord-009571-mygj2nd4 217 27 . . . cord-009571-mygj2nd4 218 1 The the DT cord-009571-mygj2nd4 218 2 ability ability NN cord-009571-mygj2nd4 218 3 of of IN cord-009571-mygj2nd4 218 4 old old JJ cord-009571-mygj2nd4 218 5 B B NNP cord-009571-mygj2nd4 218 6 / / SYM cord-009571-mygj2nd4 218 7 W W NNP cord-009571-mygj2nd4 218 8 T t NN cord-009571-mygj2nd4 218 9 cells cell NNS cord-009571-mygj2nd4 218 10 to to TO cord-009571-mygj2nd4 218 11 exhibit exhibit VB cord-009571-mygj2nd4 218 12 inhibitory inhibitory JJ cord-009571-mygj2nd4 218 13 effects effect NNS cord-009571-mygj2nd4 218 14 similar similar JJ cord-009571-mygj2nd4 218 15 to to IN cord-009571-mygj2nd4 218 16 those those DT cord-009571-mygj2nd4 218 17 of of IN cord-009571-mygj2nd4 218 18 young young JJ cord-009571-mygj2nd4 218 19 preautoimmune preautoimmune NNP cord-009571-mygj2nd4 218 20 B B NNP cord-009571-mygj2nd4 218 21 / / SYM cord-009571-mygj2nd4 218 22 W W NNP cord-009571-mygj2nd4 218 23 mice mouse NNS cord-009571-mygj2nd4 218 24 on on IN cord-009571-mygj2nd4 218 25 the the DT cord-009571-mygj2nd4 218 26 in in FW cord-009571-mygj2nd4 218 27 vitro vitro FW cord-009571-mygj2nd4 218 28 antinucleic antinucleic VBZ cord-009571-mygj2nd4 218 29 acid acid JJ cord-009571-mygj2nd4 218 30 antibody antibody NN cord-009571-mygj2nd4 218 31 response response NN cord-009571-mygj2nd4 218 32 suggests suggest VBZ cord-009571-mygj2nd4 218 33 that that IN cord-009571-mygj2nd4 218 34 the the DT cord-009571-mygj2nd4 218 35 suppressor suppressor NN cord-009571-mygj2nd4 218 36 potential potential NN cord-009571-mygj2nd4 218 37 of of IN cord-009571-mygj2nd4 218 38 these these DT cord-009571-mygj2nd4 218 39 old old JJ cord-009571-mygj2nd4 218 40 B B NNP cord-009571-mygj2nd4 218 41 / / SYM cord-009571-mygj2nd4 218 42 W W NNP cord-009571-mygj2nd4 218 43 T t NN cord-009571-mygj2nd4 218 44 cells cell NNS cord-009571-mygj2nd4 218 45 may may MD cord-009571-mygj2nd4 218 46 be be VB cord-009571-mygj2nd4 218 47 blocked block VBN cord-009571-mygj2nd4 218 48 in in IN cord-009571-mygj2nd4 218 49 vivo vivo NN cord-009571-mygj2nd4 218 50 . . . cord-009571-mygj2nd4 219 1 The the DT cord-009571-mygj2nd4 219 2 Ehlers Ehlers NNP cord-009571-mygj2nd4 219 3 - - HYPH cord-009571-mygj2nd4 219 4 Danlos Danlos NNP cord-009571-mygj2nd4 219 5 syndrome syndrome NN cord-009571-mygj2nd4 219 6 ( ( -LRB- cord-009571-mygj2nd4 219 7 ED ED NNP cord-009571-mygj2nd4 219 8 - - HYPH cord-009571-mygj2nd4 219 9 S S NNP cord-009571-mygj2nd4 219 10 ) ) -RRB- cord-009571-mygj2nd4 219 11 is be VBZ cord-009571-mygj2nd4 219 12 an an DT cord-009571-mygj2nd4 219 13 uncommon uncommon JJ cord-009571-mygj2nd4 219 14 , , , cord-009571-mygj2nd4 219 15 genetically genetically RB cord-009571-mygj2nd4 219 16 determined determine VBN cord-009571-mygj2nd4 219 17 disorder disorder NN cord-009571-mygj2nd4 219 18 of of IN cord-009571-mygj2nd4 219 19 connective connective JJ cord-009571-mygj2nd4 219 20 tissue tissue NN cord-009571-mygj2nd4 219 21 . . . cord-009571-mygj2nd4 220 1 Of of IN cord-009571-mygj2nd4 220 2 the the DT cord-009571-mygj2nd4 220 3 seven seven CD cord-009571-mygj2nd4 220 4 clinically clinically RB cord-009571-mygj2nd4 220 5 distinct distinct JJ cord-009571-mygj2nd4 220 6 types type NNS cord-009571-mygj2nd4 220 7 , , , cord-009571-mygj2nd4 220 8 a a DT cord-009571-mygj2nd4 220 9 basic basic JJ cord-009571-mygj2nd4 220 10 molecular molecular JJ cord-009571-mygj2nd4 220 11 defect defect NN cord-009571-mygj2nd4 220 12 has have VBZ cord-009571-mygj2nd4 220 13 been be VBN cord-009571-mygj2nd4 220 14 reported report VBN cord-009571-mygj2nd4 220 15 in in IN cord-009571-mygj2nd4 220 16 Types Types NNP cord-009571-mygj2nd4 220 17 IV IV NNP cord-009571-mygj2nd4 220 18 , , , cord-009571-mygj2nd4 220 19 VI VI NNP cord-009571-mygj2nd4 220 20 , , , cord-009571-mygj2nd4 220 21 and and CC cord-009571-mygj2nd4 220 22 VII VII NNP cord-009571-mygj2nd4 220 23 , , , cord-009571-mygj2nd4 220 24 all all DT cord-009571-mygj2nd4 220 25 of of IN cord-009571-mygj2nd4 220 26 which which WDT cord-009571-mygj2nd4 220 27 are be VBP cord-009571-mygj2nd4 220 28 inherited inherit VBN cord-009571-mygj2nd4 220 29 by by IN cord-009571-mygj2nd4 220 30 a a DT cord-009571-mygj2nd4 220 31 recessive recessive JJ cord-009571-mygj2nd4 220 32 mode mode NN cord-009571-mygj2nd4 220 33 , , , cord-009571-mygj2nd4 220 34 and and CC cord-009571-mygj2nd4 220 35 appear appear VB cord-009571-mygj2nd4 220 36 to to TO cord-009571-mygj2nd4 220 37 be be VB cord-009571-mygj2nd4 220 38 related relate VBN cord-009571-mygj2nd4 220 39 to to IN cord-009571-mygj2nd4 220 40 deficiencies deficiency NNS cord-009571-mygj2nd4 220 41 in in IN cord-009571-mygj2nd4 220 42 the the DT cord-009571-mygj2nd4 220 43 activity activity NN cord-009571-mygj2nd4 220 44 of of IN cord-009571-mygj2nd4 220 45 specific specific JJ cord-009571-mygj2nd4 220 46 enzymes enzyme NNS cord-009571-mygj2nd4 220 47 involved involve VBN cord-009571-mygj2nd4 220 48 in in IN cord-009571-mygj2nd4 220 49 postribosomal postribosomal JJ cord-009571-mygj2nd4 220 50 changes change NNS cord-009571-mygj2nd4 220 51 . . . cord-009571-mygj2nd4 221 1 Types type NNS cord-009571-mygj2nd4 221 2 I -PRON- PRP cord-009571-mygj2nd4 221 3 to to IN cord-009571-mygj2nd4 221 4 I11 I11 NNP cord-009571-mygj2nd4 221 5 are be VBP cord-009571-mygj2nd4 221 6 inherited inherit VBN cord-009571-mygj2nd4 221 7 by by IN cord-009571-mygj2nd4 221 8 a a DT cord-009571-mygj2nd4 221 9 dominant dominant JJ cord-009571-mygj2nd4 221 10 mode mode NN cord-009571-mygj2nd4 221 11 and and CC cord-009571-mygj2nd4 221 12 might may MD cord-009571-mygj2nd4 221 13 be be VB cord-009571-mygj2nd4 221 14 expected expect VBN cord-009571-mygj2nd4 221 15 to to TO cord-009571-mygj2nd4 221 16 have have VB cord-009571-mygj2nd4 221 17 defects defect NNS cord-009571-mygj2nd4 221 18 at at IN cord-009571-mygj2nd4 221 19 the the DT cord-009571-mygj2nd4 221 20 transcriptional transcriptional JJ cord-009571-mygj2nd4 221 21 level level NN cord-009571-mygj2nd4 221 22 . . . cord-009571-mygj2nd4 222 1 Type type NN cord-009571-mygj2nd4 222 2 V v NN cord-009571-mygj2nd4 222 3 is be VBZ cord-009571-mygj2nd4 222 4 sex sex NN cord-009571-mygj2nd4 222 5 - - HYPH cord-009571-mygj2nd4 222 6 linked link VBN cord-009571-mygj2nd4 222 7 and and CC cord-009571-mygj2nd4 222 8 has have VBZ cord-009571-mygj2nd4 222 9 been be VBN cord-009571-mygj2nd4 222 10 reported report VBN cord-009571-mygj2nd4 222 11 to to TO cord-009571-mygj2nd4 222 12 result result VB cord-009571-mygj2nd4 222 13 from from IN cord-009571-mygj2nd4 222 14 a a DT cord-009571-mygj2nd4 222 15 cross cross JJ cord-009571-mygj2nd4 222 16 - - JJ cord-009571-mygj2nd4 222 17 link link JJ cord-009571-mygj2nd4 222 18 deficiency deficiency NN cord-009571-mygj2nd4 222 19 . . . cord-009571-mygj2nd4 223 1 We -PRON- PRP cord-009571-mygj2nd4 223 2 have have VBP cord-009571-mygj2nd4 223 3 studied study VBN cord-009571-mygj2nd4 223 4 8 8 CD cord-009571-mygj2nd4 223 5 patients patient NNS cord-009571-mygj2nd4 223 6 with with IN cord-009571-mygj2nd4 223 7 ED ED NNP cord-009571-mygj2nd4 223 8 - - HYPH cord-009571-mygj2nd4 223 9 S S NNP cord-009571-mygj2nd4 223 10 Type type NN cord-009571-mygj2nd4 223 11 I i NN cord-009571-mygj2nd4 223 12 , , , cord-009571-mygj2nd4 223 13 3 3 CD cord-009571-mygj2nd4 223 14 patients patient NNS cord-009571-mygj2nd4 223 15 with with IN cord-009571-mygj2nd4 223 16 Type type NN cord-009571-mygj2nd4 223 17 11 11 CD cord-009571-mygj2nd4 223 18 , , , cord-009571-mygj2nd4 223 19 and and CC cord-009571-mygj2nd4 223 20 3 3 CD cord-009571-mygj2nd4 223 21 with with IN cord-009571-mygj2nd4 224 1 the the DT cord-009571-mygj2nd4 224 2 X x NN cord-009571-mygj2nd4 224 3 - - HYPH cord-009571-mygj2nd4 224 4 linked link VBN cord-009571-mygj2nd4 224 5 Type type NN cord-009571-mygj2nd4 224 6 V. V. NNP cord-009571-mygj2nd4 224 7 The the DT cord-009571-mygj2nd4 224 8 results result NNS cord-009571-mygj2nd4 224 9 show show VBP cord-009571-mygj2nd4 224 10 that that IN cord-009571-mygj2nd4 224 11 the the DT cord-009571-mygj2nd4 224 12 reducible reducible JJ cord-009571-mygj2nd4 224 13 crosslinks crosslink NNS cord-009571-mygj2nd4 224 14 are be VBP cord-009571-mygj2nd4 224 15 present present JJ cord-009571-mygj2nd4 224 16 and and CC cord-009571-mygj2nd4 224 17 undergo undergo VB cord-009571-mygj2nd4 224 18 the the DT cord-009571-mygj2nd4 224 19 same same JJ cord-009571-mygj2nd4 224 20 maturation maturation NN cord-009571-mygj2nd4 224 21 process process NN cord-009571-mygj2nd4 224 22 to to IN cord-009571-mygj2nd4 224 23 nonreducible nonreducible JJ cord-009571-mygj2nd4 224 24 cross cross NN cord-009571-mygj2nd4 224 25 - - NNS cord-009571-mygj2nd4 224 26 links link NNS cord-009571-mygj2nd4 224 27 as as IN cord-009571-mygj2nd4 224 28 in in IN cord-009571-mygj2nd4 224 29 normal normal JJ cord-009571-mygj2nd4 224 30 skin skin NN cord-009571-mygj2nd4 224 31 . . . cord-009571-mygj2nd4 225 1 We -PRON- PRP cord-009571-mygj2nd4 225 2 were be VBD cord-009571-mygj2nd4 225 3 unable unable JJ cord-009571-mygj2nd4 225 4 to to TO cord-009571-mygj2nd4 225 5 confirm confirm VB cord-009571-mygj2nd4 225 6 the the DT cord-009571-mygj2nd4 225 7 absence absence NN cord-009571-mygj2nd4 225 8 of of IN cord-009571-mygj2nd4 225 9 reducible reducible JJ cord-009571-mygj2nd4 225 10 cross cross NN cord-009571-mygj2nd4 225 11 - - NN cord-009571-mygj2nd4 225 12 links link NNS cord-009571-mygj2nd4 225 13 in in IN cord-009571-mygj2nd4 225 14 the the DT cord-009571-mygj2nd4 225 15 X x NN cord-009571-mygj2nd4 225 16 - - HYPH cord-009571-mygj2nd4 225 17 linked link VBN cord-009571-mygj2nd4 225 18 type type NN cord-009571-mygj2nd4 225 19 ED ED NNP cord-009571-mygj2nd4 225 20 - - HYPH cord-009571-mygj2nd4 225 21 S. S. NNP cord-009571-mygj2nd4 226 1 The the DT cord-009571-mygj2nd4 226 2 ability ability NN cord-009571-mygj2nd4 226 3 of of IN cord-009571-mygj2nd4 226 4 the the DT cord-009571-mygj2nd4 226 5 ED ED NNP cord-009571-mygj2nd4 226 6 - - HYPH cord-009571-mygj2nd4 226 7 S s NN cord-009571-mygj2nd4 226 8 skin skin NN cord-009571-mygj2nd4 226 9 to to TO cord-009571-mygj2nd4 226 10 produce produce VB cord-009571-mygj2nd4 226 11 apparently apparently RB cord-009571-mygj2nd4 226 12 normal normal JJ cord-009571-mygj2nd4 226 13 cross cross NN cord-009571-mygj2nd4 226 14 - - JJ cord-009571-mygj2nd4 226 15 linked link VBN cord-009571-mygj2nd4 226 16 collagen collagen NN cord-009571-mygj2nd4 226 17 was be VBD cord-009571-mygj2nd4 226 18 supported support VBN cord-009571-mygj2nd4 226 19 by by IN cord-009571-mygj2nd4 226 20 cell cell NN cord-009571-mygj2nd4 226 21 and and CC cord-009571-mygj2nd4 226 22 tissue tissue NN cord-009571-mygj2nd4 226 23 culture culture NN cord-009571-mygj2nd4 226 24 studies study NNS cord-009571-mygj2nd4 226 25 . . . cord-009571-mygj2nd4 227 1 Transmission transmission NN cord-009571-mygj2nd4 227 2 electron electron NN cord-009571-mygj2nd4 227 3 micr micr NN cord-009571-mygj2nd4 227 4 ~ ~ NFP cord-009571-mygj2nd4 227 5 scopy scopy NN cord-009571-mygj2nd4 227 6 and and CC cord-009571-mygj2nd4 227 7 optical optical JJ cord-009571-mygj2nd4 227 8 birefringence birefringence NN cord-009571-mygj2nd4 227 9 revealed reveal VBD cord-009571-mygj2nd4 227 10 a a DT cord-009571-mygj2nd4 227 11 normal normal JJ cord-009571-mygj2nd4 227 12 ultrastructure ultrastructure NN cord-009571-mygj2nd4 227 13 of of IN cord-009571-mygj2nd4 227 14 the the DT cord-009571-mygj2nd4 227 15 collagen collagen NN cord-009571-mygj2nd4 227 16 fibrils fibril NNS cord-009571-mygj2nd4 227 17 . . . cord-009571-mygj2nd4 228 1 At at IN cord-009571-mygj2nd4 228 2 a a DT cord-009571-mygj2nd4 228 3 higher high JJR cord-009571-mygj2nd4 228 4 morphological morphological JJ cord-009571-mygj2nd4 228 5 level level NN cord-009571-mygj2nd4 228 6 of of IN cord-009571-mygj2nd4 228 7 organization organization NN cord-009571-mygj2nd4 228 8 scanning scanning NN cord-009571-mygj2nd4 228 9 electron electron NN cord-009571-mygj2nd4 228 10 microscopy microscopy NNP cord-009571-mygj2nd4 228 11 demonstrated demonstrate VBD cord-009571-mygj2nd4 228 12 a a DT cord-009571-mygj2nd4 228 13 gradual gradual JJ cord-009571-mygj2nd4 228 14 increase increase NN cord-009571-mygj2nd4 228 15 in in IN cord-009571-mygj2nd4 228 16 fiber fiber NN cord-009571-mygj2nd4 228 17 bundle bundle NN cord-009571-mygj2nd4 228 18 disorder disorder NN cord-009571-mygj2nd4 228 19 from from IN cord-009571-mygj2nd4 228 20 the the DT cord-009571-mygj2nd4 228 21 X x NN cord-009571-mygj2nd4 228 22 - - HYPH cord-009571-mygj2nd4 228 23 linked link VBN cord-009571-mygj2nd4 228 24 to to IN cord-009571-mygj2nd4 228 25 the the DT cord-009571-mygj2nd4 228 26 myasthenia myasthenia NN cord-009571-mygj2nd4 228 27 gravis gravis NN cord-009571-mygj2nd4 228 28 , , , cord-009571-mygj2nd4 228 29 where where WRB cord-009571-mygj2nd4 228 30 the the DT cord-009571-mygj2nd4 228 31 fibers fiber NNS cord-009571-mygj2nd4 228 32 making make VBG cord-009571-mygj2nd4 228 33 up up RP cord-009571-mygj2nd4 228 34 the the DT cord-009571-mygj2nd4 228 35 large large JJ cord-009571-mygj2nd4 228 36 fiber fiber NN cord-009571-mygj2nd4 228 37 bundles bundle NNS cord-009571-mygj2nd4 228 38 demonstrated demonstrate VBD cord-009571-mygj2nd4 228 39 a a DT cord-009571-mygj2nd4 228 40 considerable considerable JJ cord-009571-mygj2nd4 228 41 inability inability NN cord-009571-mygj2nd4 228 42 to to TO cord-009571-mygj2nd4 228 43 aggregate aggregate VB cord-009571-mygj2nd4 228 44 . . . cord-009571-mygj2nd4 229 1 This this DT cord-009571-mygj2nd4 229 2 disorder disorder NN cord-009571-mygj2nd4 229 3 could could MD cord-009571-mygj2nd4 229 4 account account VB cord-009571-mygj2nd4 229 5 for for IN cord-009571-mygj2nd4 229 6 the the DT cord-009571-mygj2nd4 229 7 prolonged prolonged JJ cord-009571-mygj2nd4 229 8 lag lag NN cord-009571-mygj2nd4 229 9 phase phase NN cord-009571-mygj2nd4 229 10 in in IN cord-009571-mygj2nd4 229 11 the the DT cord-009571-mygj2nd4 229 12 stressstrain stressstrain NN cord-009571-mygj2nd4 229 13 curves curve NNS cord-009571-mygj2nd4 229 14 , , , cord-009571-mygj2nd4 229 15 while while IN cord-009571-mygj2nd4 229 16 the the DT cord-009571-mygj2nd4 229 17 presence presence NN cord-009571-mygj2nd4 229 18 of of IN cord-009571-mygj2nd4 229 19 cross cross NN cord-009571-mygj2nd4 229 20 - - NNS cord-009571-mygj2nd4 229 21 links link NNS cord-009571-mygj2nd4 229 22 ensures ensure VBZ cord-009571-mygj2nd4 229 23 that that IN cord-009571-mygj2nd4 229 24 once once IN cord-009571-mygj2nd4 229 25 stress stress NN cord-009571-mygj2nd4 229 26 is be VBZ cord-009571-mygj2nd4 229 27 on on IN cord-009571-mygj2nd4 229 28 the the DT cord-009571-mygj2nd4 229 29 individual individual JJ cord-009571-mygj2nd4 229 30 fibers fiber NNS cord-009571-mygj2nd4 229 31 the the DT cord-009571-mygj2nd4 229 32 elasting elasting NN cord-009571-mygj2nd4 229 33 modulus modulus NN cord-009571-mygj2nd4 229 34 is be VBZ cord-009571-mygj2nd4 229 35 normal normal JJ cord-009571-mygj2nd4 229 36 and and CC cord-009571-mygj2nd4 229 37 the the DT cord-009571-mygj2nd4 229 38 skin skin NN cord-009571-mygj2nd4 229 39 can can MD cord-009571-mygj2nd4 229 40 return return VB cord-009571-mygj2nd4 229 41 to to IN cord-009571-mygj2nd4 229 42 normal normal JJ cord-009571-mygj2nd4 229 43 after after IN cord-009571-mygj2nd4 229 44 hyperextension hyperextension NN cord-009571-mygj2nd4 229 45 . . . cord-009571-mygj2nd4 230 1 The the DT cord-009571-mygj2nd4 230 2 absence absence NN cord-009571-mygj2nd4 230 3 of of IN cord-009571-mygj2nd4 230 4 cross cross NN cord-009571-mygj2nd4 230 5 - - NNS cord-009571-mygj2nd4 230 6 links link NNS cord-009571-mygj2nd4 230 7 would would MD cord-009571-mygj2nd4 230 8 lead lead VB cord-009571-mygj2nd4 230 9 to to IN cord-009571-mygj2nd4 230 10 an an DT cord-009571-mygj2nd4 230 11 irreversible irreversible JJ cord-009571-mygj2nd4 230 12 elongation elongation NN cord-009571-mygj2nd4 230 13 of of IN cord-009571-mygj2nd4 230 14 the the DT cord-009571-mygj2nd4 230 15 fiber fiber NN cord-009571-mygj2nd4 230 16 . . . cord-009571-mygj2nd4 231 1 The the DT cord-009571-mygj2nd4 231 2 low low JJ cord-009571-mygj2nd4 231 3 breaking breaking NN cord-009571-mygj2nd4 231 4 point point NN cord-009571-mygj2nd4 231 5 of of IN cord-009571-mygj2nd4 231 6 the the DT cord-009571-mygj2nd4 231 7 fiber fiber NN cord-009571-mygj2nd4 231 8 is be VBZ cord-009571-mygj2nd4 231 9 therefore therefore RB cord-009571-mygj2nd4 231 10 due due IN cord-009571-mygj2nd4 231 11 to to IN cord-009571-mygj2nd4 231 12 the the DT cord-009571-mygj2nd4 231 13 lack lack NN cord-009571-mygj2nd4 231 14 of of IN cord-009571-mygj2nd4 231 15 integrity integrity NN cord-009571-mygj2nd4 231 16 of of IN cord-009571-mygj2nd4 231 17 the the DT cord-009571-mygj2nd4 231 18 fiber fiber NN cord-009571-mygj2nd4 231 19 bundles bundle NNS cord-009571-mygj2nd4 231 20 and and CC cord-009571-mygj2nd4 231 21 suggests suggest VBZ cord-009571-mygj2nd4 231 22 that that IN cord-009571-mygj2nd4 231 23 the the DT cord-009571-mygj2nd4 231 24 defect defect NN cord-009571-mygj2nd4 231 25 lies lie VBZ cord-009571-mygj2nd4 231 26 at at IN cord-009571-mygj2nd4 231 27 a a DT cord-009571-mygj2nd4 231 28 higher high JJR cord-009571-mygj2nd4 231 29 order order NN cord-009571-mygj2nd4 231 30 of of IN cord-009571-mygj2nd4 231 31 organization organization NN cord-009571-mygj2nd4 231 32 . . . cord-009571-mygj2nd4 232 1 The the DT cord-009571-mygj2nd4 232 2 cryoprecipitates cryoprecipitate NNS cord-009571-mygj2nd4 232 3 ( ( -LRB- cord-009571-mygj2nd4 232 4 cryos cryos NNP cord-009571-mygj2nd4 232 5 ) ) -RRB- cord-009571-mygj2nd4 232 6 from from IN cord-009571-mygj2nd4 232 7 many many JJ cord-009571-mygj2nd4 232 8 SLE SLE NNP cord-009571-mygj2nd4 232 9 sera sera NNP cord-009571-mygj2nd4 232 10 contain contain VBP cord-009571-mygj2nd4 232 11 lymphocytotoxic lymphocytotoxic JJ cord-009571-mygj2nd4 232 12 antibody antibody NN cord-009571-mygj2nd4 232 13 and and CC cord-009571-mygj2nd4 232 14 , , , cord-009571-mygj2nd4 232 15 when when WRB cord-009571-mygj2nd4 232 16 used use VBN cord-009571-mygj2nd4 232 17 to to TO cord-009571-mygj2nd4 232 18 immunize immunize VB cord-009571-mygj2nd4 232 19 rabbits rabbit NNS cord-009571-mygj2nd4 232 20 , , , cord-009571-mygj2nd4 232 21 induce induce VB cord-009571-mygj2nd4 232 22 antibodies antibody NNS cord-009571-mygj2nd4 232 23 to to IN cord-009571-mygj2nd4 232 24 human human JJ cord-009571-mygj2nd4 232 25 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 232 26 , , , cord-009571-mygj2nd4 232 27 suggesting suggest VBG cord-009571-mygj2nd4 232 28 that that IN cord-009571-mygj2nd4 232 29 they -PRON- PRP cord-009571-mygj2nd4 232 30 contain contain VBP cord-009571-mygj2nd4 232 31 membrane membrane NN cord-009571-mygj2nd4 232 32 fragments fragment NNS cord-009571-mygj2nd4 232 33 complexed complexed JJ cord-009571-mygj2nd4 232 34 to to IN cord-009571-mygj2nd4 232 35 antibody antibody NN cord-009571-mygj2nd4 232 36 . . . cord-009571-mygj2nd4 233 1 Lymphocyte lymphocyte NN cord-009571-mygj2nd4 233 2 - - HYPH cord-009571-mygj2nd4 233 3 reactive reactive JJ cord-009571-mygj2nd4 233 4 antibodies antibody NNS cord-009571-mygj2nd4 233 5 in in IN cord-009571-mygj2nd4 233 6 SLE SLE NNP cord-009571-mygj2nd4 233 7 sera sera NNP cord-009571-mygj2nd4 233 8 also also RB cord-009571-mygj2nd4 233 9 recognized recognize VBD cord-009571-mygj2nd4 233 10 antigens antigen NNS cord-009571-mygj2nd4 233 11 on on IN cord-009571-mygj2nd4 233 12 neuronal neuronal JJ cord-009571-mygj2nd4 233 13 cells cell NNS cord-009571-mygj2nd4 233 14 . . . cord-009571-mygj2nd4 234 1 To to TO cord-009571-mygj2nd4 234 2 determine determine VB cord-009571-mygj2nd4 234 3 whether whether IN cord-009571-mygj2nd4 234 4 the the DT cord-009571-mygj2nd4 234 5 membrane membrane NN cord-009571-mygj2nd4 234 6 fragments fragment NNS cord-009571-mygj2nd4 234 7 in in IN cord-009571-mygj2nd4 234 8 the the DT cord-009571-mygj2nd4 234 9 cryos cryos NNP cord-009571-mygj2nd4 234 10 have have VBP cord-009571-mygj2nd4 234 11 the the DT cord-009571-mygj2nd4 234 12 antigenic antigenic JJ cord-009571-mygj2nd4 234 13 determinants determinant NNS cord-009571-mygj2nd4 234 14 shared share VBN cord-009571-mygj2nd4 234 15 with with IN cord-009571-mygj2nd4 234 16 neurons neuron NNS cord-009571-mygj2nd4 234 17 , , , cord-009571-mygj2nd4 234 18 antisera antisera NNP cord-009571-mygj2nd4 234 19 generated generate VBD cord-009571-mygj2nd4 234 20 against against IN cord-009571-mygj2nd4 234 21 12 12 CD cord-009571-mygj2nd4 234 22 SLE SLE NNP cord-009571-mygj2nd4 234 23 cryos cryos NNP cord-009571-mygj2nd4 234 24 were be VBD cord-009571-mygj2nd4 234 25 tested test VBN cord-009571-mygj2nd4 234 26 in in IN cord-009571-mygj2nd4 234 27 an an DT cord-009571-mygj2nd4 234 28 antibody antibody NN cord-009571-mygj2nd4 234 29 - - HYPH cord-009571-mygj2nd4 234 30 dependent dependent JJ cord-009571-mygj2nd4 234 31 , , , cord-009571-mygj2nd4 234 32 cell cell NN cord-009571-mygj2nd4 234 33 - - HYPH cord-009571-mygj2nd4 234 34 mediated mediate VBN cord-009571-mygj2nd4 234 35 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 234 36 assay assay NN cord-009571-mygj2nd4 234 37 by by IN cord-009571-mygj2nd4 234 38 use use NN cord-009571-mygj2nd4 234 39 of of IN cord-009571-mygj2nd4 234 40 61Cr 61cr CD cord-009571-mygj2nd4 234 41 - - HYPH cord-009571-mygj2nd4 234 42 labeled label VBN cord-009571-mygj2nd4 234 43 human human JJ cord-009571-mygj2nd4 234 44 neuronal neuronal JJ cord-009571-mygj2nd4 234 45 cells cell NNS cord-009571-mygj2nd4 234 46 , , , cord-009571-mygj2nd4 234 47 SK SK NNP cord-009571-mygj2nd4 234 48 - - HYPH cord-009571-mygj2nd4 234 49 N N NNP cord-009571-mygj2nd4 234 50 - - HYPH cord-009571-mygj2nd4 234 51 SH SH NNP cord-009571-mygj2nd4 234 52 , , , cord-009571-mygj2nd4 234 53 as as IN cord-009571-mygj2nd4 234 54 targets target NNS cord-009571-mygj2nd4 234 55 and and CC cord-009571-mygj2nd4 234 56 normal normal JJ cord-009571-mygj2nd4 234 57 human human JJ cord-009571-mygj2nd4 234 58 peripheral peripheral JJ cord-009571-mygj2nd4 234 59 blood blood NN cord-009571-mygj2nd4 234 60 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 234 61 ( ( -LRB- cord-009571-mygj2nd4 234 62 PBL PBL NNP cord-009571-mygj2nd4 234 63 ) ) -RRB- cord-009571-mygj2nd4 234 64 as as IN cord-009571-mygj2nd4 234 65 effectors effector NNS cord-009571-mygj2nd4 234 66 . . . cord-009571-mygj2nd4 235 1 The the DT cord-009571-mygj2nd4 235 2 anti anti JJ cord-009571-mygj2nd4 235 3 - - JJ cord-009571-mygj2nd4 235 4 cryos cryos NNP cord-009571-mygj2nd4 235 5 produced produce VBD cord-009571-mygj2nd4 235 6 9.7 9.7 CD cord-009571-mygj2nd4 235 7 f f NN cord-009571-mygj2nd4 235 8 3.8 3.8 CD cord-009571-mygj2nd4 235 9 mean mean VBP cord-009571-mygj2nd4 235 10 % % NN cord-009571-mygj2nd4 235 11 " " `` cord-009571-mygj2nd4 235 12 Cr cr NN cord-009571-mygj2nd4 235 13 - - NN cord-009571-mygj2nd4 235 14 release release NN cord-009571-mygj2nd4 235 15 . . . cord-009571-mygj2nd4 236 1 Two two CD cord-009571-mygj2nd4 236 2 of of IN cord-009571-mygj2nd4 236 3 the the DT cord-009571-mygj2nd4 236 4 antisera antisera NN cord-009571-mygj2nd4 236 5 were be VBD cord-009571-mygj2nd4 236 6 strongly strongly RB cord-009571-mygj2nd4 236 7 positive positive JJ cord-009571-mygj2nd4 236 8 at at IN cord-009571-mygj2nd4 236 9 35 35 CD cord-009571-mygj2nd4 236 10 and and CC cord-009571-mygj2nd4 236 11 38 38 CD cord-009571-mygj2nd4 236 12 % % NN cord-009571-mygj2nd4 236 13 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 236 14 , , , cord-009571-mygj2nd4 236 15 and and CC cord-009571-mygj2nd4 236 16 3 3 CD cord-009571-mygj2nd4 236 17 others other NNS cord-009571-mygj2nd4 236 18 were be VBD cord-009571-mygj2nd4 236 19 modestly modestly RB cord-009571-mygj2nd4 236 20 cytotoxic cytotoxic JJ cord-009571-mygj2nd4 236 21 in in IN cord-009571-mygj2nd4 236 22 the the DT cord-009571-mygj2nd4 236 23 range range NN cord-009571-mygj2nd4 236 24 of of IN cord-009571-mygj2nd4 236 25 8.3 8.3 CD cord-009571-mygj2nd4 236 26 to to TO cord-009571-mygj2nd4 236 27 12.4 12.4 CD cord-009571-mygj2nd4 236 28 % % NN cord-009571-mygj2nd4 236 29 . . . cord-009571-mygj2nd4 237 1 The the DT cord-009571-mygj2nd4 237 2 remaining remain VBG cord-009571-mygj2nd4 237 3 antisera antisera NN cord-009571-mygj2nd4 237 4 were be VBD cord-009571-mygj2nd4 237 5 not not RB cord-009571-mygj2nd4 237 6 significantly significantly RB cord-009571-mygj2nd4 237 7 different different JJ cord-009571-mygj2nd4 237 8 from from IN cord-009571-mygj2nd4 237 9 the the DT cord-009571-mygj2nd4 237 10 controls control NNS cord-009571-mygj2nd4 237 11 ; ; : cord-009571-mygj2nd4 237 12 1.3 1.3 CD cord-009571-mygj2nd4 237 13 f f CD cord-009571-mygj2nd4 237 14 0.3 0.3 CD cord-009571-mygj2nd4 237 15 % % NN cord-009571-mygj2nd4 237 16 ' ' CD cord-009571-mygj2nd4 237 17 0-release 0-release CD cord-009571-mygj2nd4 237 18 from from IN cord-009571-mygj2nd4 237 19 12 12 CD cord-009571-mygj2nd4 237 20 normal normal JJ cord-009571-mygj2nd4 237 21 rabbit rabbit NN cord-009571-mygj2nd4 237 22 sera sera NNP cord-009571-mygj2nd4 237 23 ( ( -LRB- cord-009571-mygj2nd4 237 24 NRS NRS NNP cord-009571-mygj2nd4 237 25 ) ) -RRB- cord-009571-mygj2nd4 237 26 , , , cord-009571-mygj2nd4 237 27 and and CC cord-009571-mygj2nd4 237 28 1.7 1.7 CD cord-009571-mygj2nd4 237 29 f f NN cord-009571-mygj2nd4 237 30 0.5 0.5 CD cord-009571-mygj2nd4 237 31 % % NN cord-009571-mygj2nd4 237 32 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 237 33 from from IN cord-009571-mygj2nd4 237 34 a a DT cord-009571-mygj2nd4 237 35 control control NN cord-009571-mygj2nd4 237 36 group group NN cord-009571-mygj2nd4 237 37 consisting consist VBG cord-009571-mygj2nd4 237 38 of of IN cord-009571-mygj2nd4 237 39 4 4 CD cord-009571-mygj2nd4 237 40 non non JJ cord-009571-mygj2nd4 237 41 - - JJ cord-009571-mygj2nd4 237 42 SLE sle JJ cord-009571-mygj2nd4 237 43 anti anti JJ cord-009571-mygj2nd4 237 44 - - JJ cord-009571-mygj2nd4 237 45 cryos cryos JJ cord-009571-mygj2nd4 237 46 . . . cord-009571-mygj2nd4 238 1 The the DT cord-009571-mygj2nd4 238 2 antibody antibody NN cord-009571-mygj2nd4 238 3 activity activity NN cord-009571-mygj2nd4 238 4 was be VBD cord-009571-mygj2nd4 238 5 not not RB cord-009571-mygj2nd4 238 6 linked link VBN cord-009571-mygj2nd4 238 7 to to IN cord-009571-mygj2nd4 238 8 SK SK NNP cord-009571-mygj2nd4 238 9 - - HYPH cord-009571-mygj2nd4 238 10 N N NNP cord-009571-mygj2nd4 238 11 - - HYPH cord-009571-mygj2nd4 238 12 S S NNP cord-009571-mygj2nd4 238 13 H h NN cord-009571-mygj2nd4 238 14 cells cell NNS cord-009571-mygj2nd4 238 15 . . . cord-009571-mygj2nd4 239 1 The the DT cord-009571-mygj2nd4 239 2 same same JJ cord-009571-mygj2nd4 239 3 sera sera NNP cord-009571-mygj2nd4 239 4 reacted react VBD cord-009571-mygj2nd4 239 5 with with IN cord-009571-mygj2nd4 239 6 human human JJ cord-009571-mygj2nd4 239 7 neuronal neuronal JJ cord-009571-mygj2nd4 239 8 line line NN cord-009571-mygj2nd4 239 9 , , , cord-009571-mygj2nd4 239 10 LA LA NNP cord-009571-mygj2nd4 239 11 - - HYPH cord-009571-mygj2nd4 239 12 N-1 N-1 NNP cord-009571-mygj2nd4 239 13 , , , cord-009571-mygj2nd4 239 14 and and CC cord-009571-mygj2nd4 239 15 2 2 CD cord-009571-mygj2nd4 239 16 human human JJ cord-009571-mygj2nd4 239 17 glial glial JJ cord-009571-mygj2nd4 239 18 lines line NNS cord-009571-mygj2nd4 239 19 , , , cord-009571-mygj2nd4 239 20 A A NNP cord-009571-mygj2nd4 239 21 - - HYPH cord-009571-mygj2nd4 239 22 I72 I72 NNP cord-009571-mygj2nd4 239 23 and and CC cord-009571-mygj2nd4 239 24 U U NNP cord-009571-mygj2nd4 239 25 - - HYPH cord-009571-mygj2nd4 239 26 l18MG l18MG NNP cord-009571-mygj2nd4 239 27 . . . cord-009571-mygj2nd4 240 1 Unexpectedly unexpectedly RB cord-009571-mygj2nd4 240 2 there there EX cord-009571-mygj2nd4 240 3 was be VBD cord-009571-mygj2nd4 240 4 no no DT cord-009571-mygj2nd4 240 5 correlation correlation NN cord-009571-mygj2nd4 240 6 between between IN cord-009571-mygj2nd4 240 7 reactivity reactivity NN cord-009571-mygj2nd4 240 8 against against IN cord-009571-mygj2nd4 240 9 the the DT cord-009571-mygj2nd4 240 10 neuronal neuronal JJ cord-009571-mygj2nd4 240 11 cells cell NNS cord-009571-mygj2nd4 240 12 and and CC cord-009571-mygj2nd4 240 13 antibody antibody NN cord-009571-mygj2nd4 240 14 activity activity NN cord-009571-mygj2nd4 240 15 against against IN cord-009571-mygj2nd4 240 16 normal normal JJ cord-009571-mygj2nd4 240 17 human human JJ cord-009571-mygj2nd4 240 18 PBL pbl NN cord-009571-mygj2nd4 240 19 . . . cord-009571-mygj2nd4 241 1 Antibody antibody NN cord-009571-mygj2nd4 241 2 t t NN cord-009571-mygj2nd4 242 1 o o UH cord-009571-mygj2nd4 242 2 PBL PBL NNP cord-009571-mygj2nd4 242 3 was be VBD cord-009571-mygj2nd4 242 4 not not RB cord-009571-mygj2nd4 242 5 detected detect VBN cord-009571-mygj2nd4 242 6 in in IN cord-009571-mygj2nd4 242 7 4/5 4/5 CD cord-009571-mygj2nd4 242 8 anti anti JJ cord-009571-mygj2nd4 242 9 - - JJ cord-009571-mygj2nd4 242 10 cryos cryos JJ cord-009571-mygj2nd4 242 11 with with IN cord-009571-mygj2nd4 242 12 neuronal neuronal JJ cord-009571-mygj2nd4 242 13 antibody antibody NN cord-009571-mygj2nd4 242 14 , , , cord-009571-mygj2nd4 242 15 and and CC cord-009571-mygj2nd4 242 16 2 2 CD cord-009571-mygj2nd4 242 17 of of IN cord-009571-mygj2nd4 242 18 the the DT cord-009571-mygj2nd4 242 19 antisera antisera NN cord-009571-mygj2nd4 242 20 unreactive unreactive JJ cord-009571-mygj2nd4 242 21 with with IN cord-009571-mygj2nd4 242 22 SK SK NNP cord-009571-mygj2nd4 242 23 - - HYPH cord-009571-mygj2nd4 242 24 N N NNP cord-009571-mygj2nd4 242 25 - - HYPH cord-009571-mygj2nd4 242 26 SH SH NNP cord-009571-mygj2nd4 243 1 had have VBD cord-009571-mygj2nd4 243 2 anti anti JJ cord-009571-mygj2nd4 243 3 - - JJ cord-009571-mygj2nd4 243 4 PBL pbl JJ cord-009571-mygj2nd4 243 5 activity activity NN cord-009571-mygj2nd4 243 6 . . . cord-009571-mygj2nd4 244 1 Absorption absorption NN cord-009571-mygj2nd4 244 2 of of IN cord-009571-mygj2nd4 244 3 the the DT cord-009571-mygj2nd4 244 4 anti anti JJ cord-009571-mygj2nd4 244 5 - - JJ cord-009571-mygj2nd4 244 6 cryo cryo JJ cord-009571-mygj2nd4 244 7 reactive reactive JJ cord-009571-mygj2nd4 244 8 against against IN cord-009571-mygj2nd4 244 9 both both DT cord-009571-mygj2nd4 244 10 SK SK NNP cord-009571-mygj2nd4 244 11 - - HYPH cord-009571-mygj2nd4 244 12 N N NNP cord-009571-mygj2nd4 244 13 - - HYPH cord-009571-mygj2nd4 244 14 SH SH NNP cord-009571-mygj2nd4 244 15 and and CC cord-009571-mygj2nd4 244 16 PBL PBL NNP cord-009571-mygj2nd4 244 17 with with IN cord-009571-mygj2nd4 244 18 the the DT cord-009571-mygj2nd4 244 19 human human JJ cord-009571-mygj2nd4 244 20 lymphoblast lymphoblast NNP cord-009571-mygj2nd4 244 21 line line NN cord-009571-mygj2nd4 244 22 WLL2 WLL2 NNP cord-009571-mygj2nd4 244 23 removed remove VBD cord-009571-mygj2nd4 244 24 all all DT cord-009571-mygj2nd4 244 25 anti anti JJ cord-009571-mygj2nd4 244 26 - - JJ cord-009571-mygj2nd4 244 27 PBL pbl JJ cord-009571-mygj2nd4 244 28 activity activity NN cord-009571-mygj2nd4 244 29 but but CC cord-009571-mygj2nd4 244 30 not not RB cord-009571-mygj2nd4 244 31 the the DT cord-009571-mygj2nd4 244 32 neuronal neuronal JJ cord-009571-mygj2nd4 244 33 reactivity reactivity NN cord-009571-mygj2nd4 244 34 . . . cord-009571-mygj2nd4 245 1 Absorption absorption NN cord-009571-mygj2nd4 245 2 with with IN cord-009571-mygj2nd4 245 3 SK SK NNP cord-009571-mygj2nd4 245 4 - - HYPH cord-009571-mygj2nd4 245 5 N N NNP cord-009571-mygj2nd4 245 6 - - HYPH cord-009571-mygj2nd4 245 7 SH SH NNP cord-009571-mygj2nd4 245 8 eliminated eliminate VBD cord-009571-mygj2nd4 245 9 the the DT cord-009571-mygj2nd4 245 10 neuronal neuronal JJ cord-009571-mygj2nd4 245 11 reactivity reactivity NN cord-009571-mygj2nd4 245 12 and and CC cord-009571-mygj2nd4 245 13 also also RB cord-009571-mygj2nd4 245 14 diminished diminish VBD cord-009571-mygj2nd4 245 15 the the DT cord-009571-mygj2nd4 245 16 antibody antibody NN cord-009571-mygj2nd4 245 17 to to IN cord-009571-mygj2nd4 245 18 PBL PBL NNP cord-009571-mygj2nd4 245 19 . . . cord-009571-mygj2nd4 246 1 The the DT cord-009571-mygj2nd4 246 2 antineuronal antineuronal JJ cord-009571-mygj2nd4 246 3 activity activity NN cord-009571-mygj2nd4 246 4 was be VBD cord-009571-mygj2nd4 246 5 not not RB cord-009571-mygj2nd4 246 6 removed remove VBN cord-009571-mygj2nd4 246 7 by by IN cord-009571-mygj2nd4 246 8 absorptions absorption NNS cord-009571-mygj2nd4 246 9 with with IN cord-009571-mygj2nd4 246 10 human human JJ cord-009571-mygj2nd4 246 11 platelets platelet NNS cord-009571-mygj2nd4 246 12 and and CC cord-009571-mygj2nd4 246 13 human human JJ cord-009571-mygj2nd4 246 14 RBC RBC NNP cord-009571-mygj2nd4 246 15 . . . cord-009571-mygj2nd4 247 1 Passage passage NN cord-009571-mygj2nd4 247 2 of of IN cord-009571-mygj2nd4 247 3 the the DT cord-009571-mygj2nd4 247 4 anticryos anticryos NNP cord-009571-mygj2nd4 247 5 over over IN cord-009571-mygj2nd4 247 6 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 247 7 containing contain VBG cord-009571-mygj2nd4 247 8 immunoabsorbents immunoabsorbent NNS cord-009571-mygj2nd4 247 9 removed remove VBD cord-009571-mygj2nd4 247 10 the the DT cord-009571-mygj2nd4 247 11 detectable detectable JJ cord-009571-mygj2nd4 247 12 anti anti JJ cord-009571-mygj2nd4 247 13 - - JJ cord-009571-mygj2nd4 247 14 immunoglobulin immunoglobulin JJ cord-009571-mygj2nd4 247 15 activity activity NN cord-009571-mygj2nd4 247 16 without without IN cord-009571-mygj2nd4 247 17 diminishing diminish VBG cord-009571-mygj2nd4 247 18 the the DT cord-009571-mygj2nd4 247 19 neuronal neuronal JJ cord-009571-mygj2nd4 247 20 reactivity reactivity NN cord-009571-mygj2nd4 247 21 . . . cord-009571-mygj2nd4 248 1 Thus thus RB cord-009571-mygj2nd4 248 2 , , , cord-009571-mygj2nd4 248 3 SLE SLE NNP cord-009571-mygj2nd4 248 4 cryoproteins cryoprotein NNS cord-009571-mygj2nd4 248 5 contain contain VBP cord-009571-mygj2nd4 248 6 antigenic antigenic JJ cord-009571-mygj2nd4 248 7 determinants determinant NNS cord-009571-mygj2nd4 248 8 shared share VBN cord-009571-mygj2nd4 248 9 by by IN cord-009571-mygj2nd4 248 10 neuronal neuronal JJ cord-009571-mygj2nd4 248 11 and and CC cord-009571-mygj2nd4 248 12 glial glial JJ cord-009571-mygj2nd4 248 13 cells cell NNS cord-009571-mygj2nd4 248 14 but but CC cord-009571-mygj2nd4 248 15 not not RB cord-009571-mygj2nd4 248 16 by by IN cord-009571-mygj2nd4 248 17 the the DT cord-009571-mygj2nd4 248 18 major major JJ cord-009571-mygj2nd4 248 19 cellular cellular JJ cord-009571-mygj2nd4 248 20 elements element NNS cord-009571-mygj2nd4 248 21 in in IN cord-009571-mygj2nd4 248 22 blood blood NN cord-009571-mygj2nd4 248 23 . . . cord-009571-mygj2nd4 249 1 It -PRON- PRP cord-009571-mygj2nd4 249 2 is be VBZ cord-009571-mygj2nd4 249 3 not not RB cord-009571-mygj2nd4 249 4 yet yet RB cord-009571-mygj2nd4 249 5 clear clear JJ cord-009571-mygj2nd4 249 6 whether whether IN cord-009571-mygj2nd4 249 7 those those DT cord-009571-mygj2nd4 249 8 antigens antigen NNS cord-009571-mygj2nd4 249 9 are be VBP cord-009571-mygj2nd4 249 10 present present JJ cord-009571-mygj2nd4 249 11 on on IN cord-009571-mygj2nd4 249 12 fragments fragment NNS cord-009571-mygj2nd4 249 13 of of IN cord-009571-mygj2nd4 249 14 neuronal neuronal JJ cord-009571-mygj2nd4 249 15 membranes membrane NNS cord-009571-mygj2nd4 249 16 or or CC cord-009571-mygj2nd4 249 17 on on IN cord-009571-mygj2nd4 249 18 antigenic antigenic JJ cord-009571-mygj2nd4 249 19 structures structure NNS cord-009571-mygj2nd4 249 20 eliciting elicit VBG cord-009571-mygj2nd4 249 21 cross cross JJ cord-009571-mygj2nd4 249 22 reactive reactive JJ cord-009571-mygj2nd4 249 23 antibodies antibody NNS cord-009571-mygj2nd4 249 24 . . . cord-009571-mygj2nd4 250 1 It -PRON- PRP cord-009571-mygj2nd4 250 2 is be VBZ cord-009571-mygj2nd4 250 3 generally generally RB cord-009571-mygj2nd4 250 4 accepted accept VBN cord-009571-mygj2nd4 250 5 that that IN cord-009571-mygj2nd4 250 6 antibodies antibody NNS cord-009571-mygj2nd4 250 7 to to TO cord-009571-mygj2nd4 250 8 double double VB cord-009571-mygj2nd4 250 9 stranded strand VBN cord-009571-mygj2nd4 250 10 ( ( -LRB- cord-009571-mygj2nd4 250 11 ds ds NNP cord-009571-mygj2nd4 250 12 ) ) -RRB- cord-009571-mygj2nd4 250 13 DNA DNA NNP cord-009571-mygj2nd4 250 14 are be VBP cord-009571-mygj2nd4 250 15 a a DT cord-009571-mygj2nd4 250 16 feature feature NN cord-009571-mygj2nd4 250 17 of of IN cord-009571-mygj2nd4 250 18 active active JJ cord-009571-mygj2nd4 250 19 SLE SLE NNP cord-009571-mygj2nd4 250 20 , , , cord-009571-mygj2nd4 250 21 while while IN cord-009571-mygj2nd4 250 22 antibodies antibody NNS cord-009571-mygj2nd4 250 23 to to IN cord-009571-mygj2nd4 250 24 single single JJ cord-009571-mygj2nd4 250 25 stranded stranded JJ cord-009571-mygj2nd4 250 26 ( ( -LRB- cord-009571-mygj2nd4 250 27 ss ss NNP cord-009571-mygj2nd4 250 28 ) ) -RRB- cord-009571-mygj2nd4 250 29 DNA DNA NNP cord-009571-mygj2nd4 250 30 occur occur VBP cord-009571-mygj2nd4 250 31 in in IN cord-009571-mygj2nd4 250 32 many many JJ cord-009571-mygj2nd4 250 33 rheumatic rheumatic JJ cord-009571-mygj2nd4 250 34 diseases disease NNS cord-009571-mygj2nd4 250 35 . . . cord-009571-mygj2nd4 251 1 The the DT cord-009571-mygj2nd4 251 2 natural natural JJ cord-009571-mygj2nd4 251 3 occurrence occurrence NN cord-009571-mygj2nd4 251 4 of of IN cord-009571-mygj2nd4 251 5 antibodies antibody NNS cord-009571-mygj2nd4 251 6 to to IN cord-009571-mygj2nd4 251 7 dsDNA dsdna RB cord-009571-mygj2nd4 251 8 presumes presume VBZ cord-009571-mygj2nd4 251 9 an an DT cord-009571-mygj2nd4 251 10 interaction interaction NN cord-009571-mygj2nd4 251 11 with with IN cord-009571-mygj2nd4 251 12 the the DT cord-009571-mygj2nd4 251 13 sugar sugar NN cord-009571-mygj2nd4 251 14 - - HYPH cord-009571-mygj2nd4 251 15 phosphate phosphate NN cord-009571-mygj2nd4 251 16 backbone backbone NN cord-009571-mygj2nd4 251 17 of of IN cord-009571-mygj2nd4 251 18 DNA dna NN cord-009571-mygj2nd4 251 19 , , , cord-009571-mygj2nd4 251 20 the the DT cord-009571-mygj2nd4 251 21 immunogenicity immunogenicity NN cord-009571-mygj2nd4 251 22 of of IN cord-009571-mygj2nd4 251 23 which which WDT cord-009571-mygj2nd4 251 24 is be VBZ cord-009571-mygj2nd4 251 25 unproved unproved JJ cord-009571-mygj2nd4 251 26 . . . cord-009571-mygj2nd4 252 1 We -PRON- PRP cord-009571-mygj2nd4 252 2 have have VBP cord-009571-mygj2nd4 252 3 attempted attempt VBN cord-009571-mygj2nd4 252 4 t t NN cord-009571-mygj2nd4 252 5 o o UH cord-009571-mygj2nd4 252 6 define define VB cord-009571-mygj2nd4 252 7 the the DT cord-009571-mygj2nd4 252 8 preferential preferential JJ cord-009571-mygj2nd4 252 9 reaction reaction NN cord-009571-mygj2nd4 252 10 site site NN cord-009571-mygj2nd4 252 11 of of IN cord-009571-mygj2nd4 252 12 dsDNA dsdna JJ cord-009571-mygj2nd4 252 13 antibodies antibody NNS cord-009571-mygj2nd4 252 14 on on IN cord-009571-mygj2nd4 252 15 a a DT cord-009571-mygj2nd4 252 16 molecular molecular JJ cord-009571-mygj2nd4 252 17 species specie NNS cord-009571-mygj2nd4 252 18 of of IN cord-009571-mygj2nd4 252 19 dsDNA dsdna RB cord-009571-mygj2nd4 252 20 containing contain VBG cord-009571-mygj2nd4 252 21 the the DT cord-009571-mygj2nd4 252 22 multiple multiple JJ cord-009571-mygj2nd4 252 23 ss ss NN cord-009571-mygj2nd4 252 24 regions region NNS cord-009571-mygj2nd4 252 25 , , , cord-009571-mygj2nd4 252 26 herewith herewith VBZ cord-009571-mygj2nd4 252 27 designated designate VBN cord-009571-mygj2nd4 252 28 ds ds NNP cord-009571-mygj2nd4 252 29 / / SYM cord-009571-mygj2nd4 252 30 ssDNA ssdna NN cord-009571-mygj2nd4 252 31 . . . cord-009571-mygj2nd4 253 1 Calf calf NN cord-009571-mygj2nd4 253 2 thymus thymus NN cord-009571-mygj2nd4 253 3 DNA dna NN cord-009571-mygj2nd4 253 4 was be VBD cord-009571-mygj2nd4 253 5 sheared shear VBN cord-009571-mygj2nd4 253 6 to to IN cord-009571-mygj2nd4 253 7 a a DT cord-009571-mygj2nd4 253 8 molecular molecular JJ cord-009571-mygj2nd4 253 9 weight weight NN cord-009571-mygj2nd4 253 10 of of IN cord-009571-mygj2nd4 253 11 1 1 CD cord-009571-mygj2nd4 253 12 X x NN cord-009571-mygj2nd4 253 13 IW IW NNP cord-009571-mygj2nd4 253 14 daltons dalton NNS cord-009571-mygj2nd4 253 15 . . . cord-009571-mygj2nd4 254 1 Characterization characterization NN cord-009571-mygj2nd4 254 2 by by IN cord-009571-mygj2nd4 254 3 hydroxyapatite hydroxyapatite NN cord-009571-mygj2nd4 254 4 and and CC cord-009571-mygj2nd4 254 5 benzyolated benzyolate VBD cord-009571-mygj2nd4 254 6 naphthoylated naphthoylated JJ cord-009571-mygj2nd4 254 7 DEAE DEAE NNP cord-009571-mygj2nd4 254 8 cellulose cellulose NN cord-009571-mygj2nd4 254 9 chromatography chromatography NN cord-009571-mygj2nd4 254 10 ( ( -LRB- cord-009571-mygj2nd4 254 11 J J NNP cord-009571-mygj2nd4 254 12 Immunol Immunol NNP cord-009571-mygj2nd4 254 13 118:694 118:694 CD cord-009571-mygj2nd4 254 14 , , , cord-009571-mygj2nd4 254 15 1977 1977 CD cord-009571-mygj2nd4 254 16 ) ) -RRB- cord-009571-mygj2nd4 254 17 indicated indicate VBD cord-009571-mygj2nd4 254 18 the the DT cord-009571-mygj2nd4 254 19 DNA dna NN cord-009571-mygj2nd4 254 20 was be VBD cord-009571-mygj2nd4 254 21 predominantly predominantly RB cord-009571-mygj2nd4 254 22 ds ds NNP cord-009571-mygj2nd4 254 23 with with IN cord-009571-mygj2nd4 254 24 numerous numerous JJ cord-009571-mygj2nd4 254 25 ss ss NN cord-009571-mygj2nd4 254 26 regions region NNS cord-009571-mygj2nd4 254 27 . . . cord-009571-mygj2nd4 255 1 Antibodies antibody NNS cord-009571-mygj2nd4 255 2 to to TO cord-009571-mygj2nd4 255 3 chromatographically chromatographically VB cord-009571-mygj2nd4 255 4 pure pure JJ cord-009571-mygj2nd4 255 5 dsDNA dsdna RB cord-009571-mygj2nd4 256 1 ( ( -LRB- cord-009571-mygj2nd4 256 2 > > NFP cord-009571-mygj2nd4 256 3 80 80 CD cord-009571-mygj2nd4 256 4 % % NN cord-009571-mygj2nd4 256 5 binding bind VBG cord-009571-mygj2nd4 256 6 in in IN cord-009571-mygj2nd4 256 7 a a DT cord-009571-mygj2nd4 256 8 standard standard JJ cord-009571-mygj2nd4 256 9 Farr Farr NNP cord-009571-mygj2nd4 256 10 assay assay NN cord-009571-mygj2nd4 256 11 ) ) -RRB- cord-009571-mygj2nd4 256 12 were be VBD cord-009571-mygj2nd4 256 13 partially partially RB cord-009571-mygj2nd4 256 14 purified purify VBN cord-009571-mygj2nd4 256 15 by by IN cord-009571-mygj2nd4 256 16 ammonium ammonium NN cord-009571-mygj2nd4 256 17 sulfate sulfate NN cord-009571-mygj2nd4 256 18 precipitation precipitation NN cord-009571-mygj2nd4 256 19 , , , cord-009571-mygj2nd4 256 20 iodinated iodinate VBN cord-009571-mygj2nd4 256 21 with with IN cord-009571-mygj2nd4 256 22 lz6I lz6I NNP cord-009571-mygj2nd4 256 23 , , , cord-009571-mygj2nd4 256 24 and and CC cord-009571-mygj2nd4 256 25 reacted react VBD cord-009571-mygj2nd4 256 26 with with IN cord-009571-mygj2nd4 256 27 ds ds NNP cord-009571-mygj2nd4 256 28 / / SYM cord-009571-mygj2nd4 256 29 ssDNA ssdna NN cord-009571-mygj2nd4 256 30 . . . cord-009571-mygj2nd4 257 1 The the DT cord-009571-mygj2nd4 257 2 resulting result VBG cord-009571-mygj2nd4 257 3 complexes complex NNS cord-009571-mygj2nd4 257 4 were be VBD cord-009571-mygj2nd4 257 5 precipitated precipitate VBN cord-009571-mygj2nd4 257 6 with with IN cord-009571-mygj2nd4 257 7 4.5 4.5 CD cord-009571-mygj2nd4 257 8 % % NN cord-009571-mygj2nd4 257 9 polyethylene polyethylene NN cord-009571-mygj2nd4 257 10 glycol glycol NN cord-009571-mygj2nd4 257 11 ( ( -LRB- cord-009571-mygj2nd4 257 12 MW MW NNP cord-009571-mygj2nd4 257 13 , , , cord-009571-mygj2nd4 257 14 6000 6000 CD cord-009571-mygj2nd4 257 15 ) ) -RRB- cord-009571-mygj2nd4 257 16 and and CC cord-009571-mygj2nd4 257 17 redissolved redissolve VBD cord-009571-mygj2nd4 257 18 in in IN cord-009571-mygj2nd4 257 19 0.1 0.1 CD cord-009571-mygj2nd4 257 20 M M NNP cord-009571-mygj2nd4 257 21 tris tris NNP cord-009571-mygj2nd4 257 22 - - HYPH cord-009571-mygj2nd4 257 23 HCI HCI NNP cord-009571-mygj2nd4 257 24 , , , cord-009571-mygj2nd4 257 25 pH pH NNP cord-009571-mygj2nd4 257 26 8.0 8.0 CD cord-009571-mygj2nd4 257 27 , , , cord-009571-mygj2nd4 257 28 0.01 0.01 CD cord-009571-mygj2nd4 257 29 M M NNP cord-009571-mygj2nd4 257 30 MgCI2 MgCI2 NNP cord-009571-mygj2nd4 257 31 , , , cord-009571-mygj2nd4 257 32 0.15 0.15 CD cord-009571-mygj2nd4 257 33 M M NNP cord-009571-mygj2nd4 257 34 NaCl NaCl NNP cord-009571-mygj2nd4 257 35 ( ( -LRB- cord-009571-mygj2nd4 257 36 the the DT cord-009571-mygj2nd4 257 37 endonuclease endonuclease NN cord-009571-mygj2nd4 257 38 buffer buffer NN cord-009571-mygj2nd4 257 39 ) ) -RRB- cord-009571-mygj2nd4 257 40 . . . cord-009571-mygj2nd4 258 1 The the DT cord-009571-mygj2nd4 258 2 solubilized solubilized JJ cord-009571-mygj2nd4 258 3 complexes complex NNS cord-009571-mygj2nd4 258 4 were be VBD cord-009571-mygj2nd4 258 5 reacted react VBN cord-009571-mygj2nd4 258 6 with with IN cord-009571-mygj2nd4 258 7 ss ss NNP cord-009571-mygj2nd4 258 8 specific specific JJ cord-009571-mygj2nd4 258 9 endonuclease endonuclease NN cord-009571-mygj2nd4 258 10 from from IN cord-009571-mygj2nd4 258 11 Neurospora Neurospora NNP cord-009571-mygj2nd4 258 12 crassa crassa NN cord-009571-mygj2nd4 258 13 ( ( -LRB- cord-009571-mygj2nd4 258 14 0.5pg 0.5pg CD cord-009571-mygj2nd4 258 15 enzyme/700pg enzyme/700pg NNP cord-009571-mygj2nd4 258 16 DNA DNA NNP cord-009571-mygj2nd4 258 17 ) ) -RRB- cord-009571-mygj2nd4 258 18 and and CC cord-009571-mygj2nd4 258 19 compared compare VBD cord-009571-mygj2nd4 258 20 t t NNP cord-009571-mygj2nd4 258 21 o o NN cord-009571-mygj2nd4 258 22 undigested undigested JJ cord-009571-mygj2nd4 258 23 complexes complex NNS cord-009571-mygj2nd4 258 24 by by IN cord-009571-mygj2nd4 258 25 velocity velocity NN cord-009571-mygj2nd4 258 26 sedimentation sedimentation NN cord-009571-mygj2nd4 258 27 in in IN cord-009571-mygj2nd4 258 28 a a DT cord-009571-mygj2nd4 258 29 5 5 CD cord-009571-mygj2nd4 258 30 % % NN cord-009571-mygj2nd4 258 31 to to TO cord-009571-mygj2nd4 258 32 40 40 CD cord-009571-mygj2nd4 258 33 % % NN cord-009571-mygj2nd4 258 34 sucrose sucrose NN cord-009571-mygj2nd4 258 35 gradient gradient NN cord-009571-mygj2nd4 258 36 run run VBP cord-009571-mygj2nd4 258 37 at at IN cord-009571-mygj2nd4 258 38 135,OOOg 135,ooog CD cord-009571-mygj2nd4 258 39 for for IN cord-009571-mygj2nd4 258 40 I5 I5 NNP cord-009571-mygj2nd4 258 41 hours hour NNS cord-009571-mygj2nd4 258 42 . . . cord-009571-mygj2nd4 259 1 Undigested undigested JJ cord-009571-mygj2nd4 259 2 complexes complex NNS cord-009571-mygj2nd4 259 3 sedimented sediment VBD cord-009571-mygj2nd4 259 4 at at IN cord-009571-mygj2nd4 259 5 a a DT cord-009571-mygj2nd4 259 6 position position NN cord-009571-mygj2nd4 259 7 of of IN cord-009571-mygj2nd4 259 8 19s 19 NNS cord-009571-mygj2nd4 259 9 ; ; : cord-009571-mygj2nd4 259 10 after after IN cord-009571-mygj2nd4 259 11 endonuclease endonuclease NN cord-009571-mygj2nd4 259 12 digestion digestion NN cord-009571-mygj2nd4 259 13 there there EX cord-009571-mygj2nd4 259 14 was be VBD cord-009571-mygj2nd4 259 15 a a DT cord-009571-mygj2nd4 259 16 dramatic dramatic JJ cord-009571-mygj2nd4 259 17 decrease decrease NN cord-009571-mygj2nd4 259 18 in in IN cord-009571-mygj2nd4 259 19 the the DT cord-009571-mygj2nd4 259 20 sedimentation sedimentation NN cord-009571-mygj2nd4 259 21 velocity velocity NN cord-009571-mygj2nd4 259 22 to to IN cord-009571-mygj2nd4 259 23 a a DT cord-009571-mygj2nd4 259 24 5 5 CD cord-009571-mygj2nd4 259 25 7 7 CD cord-009571-mygj2nd4 259 26 s s NN cord-009571-mygj2nd4 259 27 position position NN cord-009571-mygj2nd4 259 28 . . . cord-009571-mygj2nd4 260 1 These these DT cord-009571-mygj2nd4 260 2 findings finding NNS cord-009571-mygj2nd4 260 3 could could MD cord-009571-mygj2nd4 260 4 be be VB cord-009571-mygj2nd4 260 5 explained explain VBN cord-009571-mygj2nd4 260 6 by by IN cord-009571-mygj2nd4 260 7 : : : cord-009571-mygj2nd4 260 8 1 1 LS cord-009571-mygj2nd4 260 9 ) ) -RRB- cord-009571-mygj2nd4 260 10 a a DT cord-009571-mygj2nd4 260 11 disintegration disintegration NN cord-009571-mygj2nd4 260 12 of of IN cord-009571-mygj2nd4 260 13 the the DT cord-009571-mygj2nd4 260 14 DNA DNA NNP cord-009571-mygj2nd4 260 15 into into IN cord-009571-mygj2nd4 260 16 many many JJ cord-009571-mygj2nd4 260 17 smaller small JJR cord-009571-mygj2nd4 260 18 ds ds NNP cord-009571-mygj2nd4 260 19 molecules molecule NNS cord-009571-mygj2nd4 260 20 still still RB cord-009571-mygj2nd4 260 21 attached attach VBN cord-009571-mygj2nd4 260 22 to to IN cord-009571-mygj2nd4 260 23 labeled label VBN cord-009571-mygj2nd4 260 24 antibodies antibody NNS cord-009571-mygj2nd4 260 25 , , , cord-009571-mygj2nd4 260 26 2 2 CD cord-009571-mygj2nd4 260 27 ) ) -RRB- cord-009571-mygj2nd4 260 28 a a DT cord-009571-mygj2nd4 260 29 liberation liberation NN cord-009571-mygj2nd4 260 30 of of IN cord-009571-mygj2nd4 260 31 antibodies antibody NNS cord-009571-mygj2nd4 260 32 formerly formerly RB cord-009571-mygj2nd4 260 33 attached attach VBN cord-009571-mygj2nd4 260 34 to to IN cord-009571-mygj2nd4 260 35 ss ss NN cord-009571-mygj2nd4 260 36 regions region NNS cord-009571-mygj2nd4 260 37 of of IN cord-009571-mygj2nd4 260 38 the the DT cord-009571-mygj2nd4 260 39 ds ds NNP cord-009571-mygj2nd4 260 40 / / SYM cord-009571-mygj2nd4 260 41 ssDNA ssdna NN cord-009571-mygj2nd4 260 42 , , , cord-009571-mygj2nd4 260 43 3 3 LS cord-009571-mygj2nd4 260 44 ) ) -RRB- cord-009571-mygj2nd4 260 45 a a DT cord-009571-mygj2nd4 260 46 displacement displacement NN cord-009571-mygj2nd4 260 47 , , , cord-009571-mygj2nd4 260 48 by by IN cord-009571-mygj2nd4 260 49 the the DT cord-009571-mygj2nd4 260 50 endonuclease endonuclease NN cord-009571-mygj2nd4 260 51 , , , cord-009571-mygj2nd4 260 52 of of IN cord-009571-mygj2nd4 260 53 antibodies antibody NNS cord-009571-mygj2nd4 260 54 reactive reactive JJ cord-009571-mygj2nd4 260 55 with with IN cord-009571-mygj2nd4 260 56 ss ss NNP cord-009571-mygj2nd4 260 57 regions region NNS cord-009571-mygj2nd4 260 58 . . . cord-009571-mygj2nd4 261 1 To to TO cord-009571-mygj2nd4 261 2 test test VB cord-009571-mygj2nd4 261 3 these these DT cord-009571-mygj2nd4 261 4 possibilities possibility NNS cord-009571-mygj2nd4 261 5 the the DT cord-009571-mygj2nd4 261 6 procedure procedure NN cord-009571-mygj2nd4 261 7 was be VBD cord-009571-mygj2nd4 261 8 repeated repeat VBN cord-009571-mygj2nd4 261 9 without without IN cord-009571-mygj2nd4 261 10 labeling labeling NN cord-009571-mygj2nd4 261 11 of of IN cord-009571-mygj2nd4 261 12 the the DT cord-009571-mygj2nd4 261 13 immunoglobulins immunoglobulin NNS cord-009571-mygj2nd4 261 14 , , , cord-009571-mygj2nd4 261 15 the the DT cord-009571-mygj2nd4 261 16 resulting result VBG cord-009571-mygj2nd4 261 17 complexes complex NNS cord-009571-mygj2nd4 261 18 were be VBD cord-009571-mygj2nd4 261 19 reacted react VBN cord-009571-mygj2nd4 261 20 with with IN cord-009571-mygj2nd4 261 21 lz5l lz5l NNP cord-009571-mygj2nd4 261 22 dsDNA dsdna RB cord-009571-mygj2nd4 261 23 in in IN cord-009571-mygj2nd4 261 24 a a DT cord-009571-mygj2nd4 261 25 standard standard JJ cord-009571-mygj2nd4 261 26 Farr Farr NNP cord-009571-mygj2nd4 261 27 assay assay NN cord-009571-mygj2nd4 261 28 . . . cord-009571-mygj2nd4 262 1 After after IN cord-009571-mygj2nd4 262 2 endonuclease endonuclease NN cord-009571-mygj2nd4 262 3 digestion digestion NN cord-009571-mygj2nd4 262 4 free free JJ cord-009571-mygj2nd4 262 5 DNA dna NN cord-009571-mygj2nd4 262 6 antibodies antibody NNS cord-009571-mygj2nd4 262 7 were be VBD cord-009571-mygj2nd4 262 8 readily readily RB cord-009571-mygj2nd4 262 9 detected detect VBN cord-009571-mygj2nd4 262 10 , , , cord-009571-mygj2nd4 262 11 as as IN cord-009571-mygj2nd4 262 12 shown show VBN cord-009571-mygj2nd4 262 13 by by IN cord-009571-mygj2nd4 262 14 a a DT cord-009571-mygj2nd4 262 15 20-fold 20-fold CD cord-009571-mygj2nd4 262 16 increase increase NN cord-009571-mygj2nd4 262 17 in in IN cord-009571-mygj2nd4 262 18 DNA dna NN cord-009571-mygj2nd4 262 19 binding binding NN cord-009571-mygj2nd4 262 20 , , , cord-009571-mygj2nd4 262 21 3 3 CD cord-009571-mygj2nd4 262 22 % % NN cord-009571-mygj2nd4 262 23 to to IN cord-009571-mygj2nd4 262 24 63 63 CD cord-009571-mygj2nd4 262 25 % % NN cord-009571-mygj2nd4 262 26 . . . cord-009571-mygj2nd4 263 1 These these DT cord-009571-mygj2nd4 263 2 findings finding NNS cord-009571-mygj2nd4 263 3 indicate indicate VBP cord-009571-mygj2nd4 263 4 that that IN cord-009571-mygj2nd4 263 5 dsDNA dsdna JJ cord-009571-mygj2nd4 263 6 antibodies antibody NNS cord-009571-mygj2nd4 263 7 preferentially preferentially RB cord-009571-mygj2nd4 263 8 react react VBP cord-009571-mygj2nd4 263 9 with with IN cord-009571-mygj2nd4 263 10 ss ss NNP cord-009571-mygj2nd4 263 11 portions portion NNS cord-009571-mygj2nd4 263 12 of of IN cord-009571-mygj2nd4 263 13 dsDNA dsdna JJ cord-009571-mygj2nd4 263 14 molecules molecule NNS cord-009571-mygj2nd4 263 15 . . . cord-009571-mygj2nd4 264 1 Whether whether IN cord-009571-mygj2nd4 264 2 dsDNA dsdna JJ cord-009571-mygj2nd4 264 3 antibodies antibody NNS cord-009571-mygj2nd4 264 4 ever ever RB cord-009571-mygj2nd4 264 5 react react VBP cord-009571-mygj2nd4 264 6 with with IN cord-009571-mygj2nd4 264 7 determinants determinant NNS cord-009571-mygj2nd4 264 8 unique unique JJ cord-009571-mygj2nd4 264 9 to to IN cord-009571-mygj2nd4 264 10 dsDNA dsdna RB cord-009571-mygj2nd4 264 11 , , , cord-009571-mygj2nd4 264 12 or or CC cord-009571-mygj2nd4 264 13 are be VBP cord-009571-mygj2nd4 264 14 merely merely RB cord-009571-mygj2nd4 264 15 a a DT cord-009571-mygj2nd4 264 16 manifestation manifestation NN cord-009571-mygj2nd4 264 17 of of IN cord-009571-mygj2nd4 264 18 high high JJ cord-009571-mygj2nd4 264 19 avidity avidity NN cord-009571-mygj2nd4 264 20 binding bind VBG cord-009571-mygj2nd4 264 21 to to IN cord-009571-mygj2nd4 264 22 a a DT cord-009571-mygj2nd4 264 23 very very RB cord-009571-mygj2nd4 264 24 short short JJ cord-009571-mygj2nd4 264 25 ss ss NN cord-009571-mygj2nd4 264 26 region region NN cord-009571-mygj2nd4 264 27 of of IN cord-009571-mygj2nd4 264 28 the the DT cord-009571-mygj2nd4 264 29 dsDNA dsdna JJ cord-009571-mygj2nd4 264 30 molecule molecule NN cord-009571-mygj2nd4 264 31 , , , cord-009571-mygj2nd4 264 32 remains remain VBZ cord-009571-mygj2nd4 264 33 to to TO cord-009571-mygj2nd4 264 34 be be VB cord-009571-mygj2nd4 264 35 determined determine VBN cord-009571-mygj2nd4 264 36 . . . cord-009571-mygj2nd4 265 1 T t NN cord-009571-mygj2nd4 265 2 cell cell NN cord-009571-mygj2nd4 265 3 cytotoxic cytotoxic JJ cord-009571-mygj2nd4 265 4 function function NN cord-009571-mygj2nd4 265 5 in in IN cord-009571-mygj2nd4 265 6 NZB nzb NN cord-009571-mygj2nd4 265 7 mice mouse NNS cord-009571-mygj2nd4 265 8 has have VBZ cord-009571-mygj2nd4 265 9 previously previously RB cord-009571-mygj2nd4 265 10 been be VBN cord-009571-mygj2nd4 265 11 tested test VBN cord-009571-mygj2nd4 265 12 utilizing utilize VBG cord-009571-mygj2nd4 265 13 target target NN cord-009571-mygj2nd4 265 14 cells cell NNS cord-009571-mygj2nd4 265 15 differing differ VBG cord-009571-mygj2nd4 265 16 from from IN cord-009571-mygj2nd4 265 17 NZB nzb NN cord-009571-mygj2nd4 265 18 at at IN cord-009571-mygj2nd4 265 19 the the DT cord-009571-mygj2nd4 265 20 major major JJ cord-009571-mygj2nd4 265 21 histocompatibility histocompatibility NN cord-009571-mygj2nd4 265 22 complex complex NN cord-009571-mygj2nd4 265 23 ( ( -LRB- cord-009571-mygj2nd4 265 24 MHC MHC NNP cord-009571-mygj2nd4 265 25 ) ) -RRB- cord-009571-mygj2nd4 265 26 of of IN cord-009571-mygj2nd4 265 27 mice mouse NNS cord-009571-mygj2nd4 265 28 , , , cord-009571-mygj2nd4 265 29 H-2 H-2 NNP cord-009571-mygj2nd4 265 30 . . . cord-009571-mygj2nd4 266 1 In in IN cord-009571-mygj2nd4 266 2 the the DT cord-009571-mygj2nd4 266 3 experiments experiment NNS cord-009571-mygj2nd4 266 4 reported report VBN cord-009571-mygj2nd4 266 5 here here RB cord-009571-mygj2nd4 266 6 , , , cord-009571-mygj2nd4 266 7 T t NN cord-009571-mygj2nd4 266 8 cell cell NN cord-009571-mygj2nd4 266 9 cytotoxic cytotoxic JJ cord-009571-mygj2nd4 266 10 functions function NNS cord-009571-mygj2nd4 266 11 of of IN cord-009571-mygj2nd4 266 12 NZB nzb NN cord-009571-mygj2nd4 266 13 mice mouse NNS cord-009571-mygj2nd4 266 14 against against IN cord-009571-mygj2nd4 266 15 targets target NNS cord-009571-mygj2nd4 266 16 identical identical JJ cord-009571-mygj2nd4 266 17 to to TO cord-009571-mygj2nd4 266 18 NZB nzb VB cord-009571-mygj2nd4 266 19 at at IN cord-009571-mygj2nd4 266 20 the the DT cord-009571-mygj2nd4 266 21 MHC MHC NNP cord-009571-mygj2nd4 266 22 were be VBD cord-009571-mygj2nd4 266 23 investigated investigate VBN cord-009571-mygj2nd4 266 24 . . . cord-009571-mygj2nd4 267 1 Normal normal JJ cord-009571-mygj2nd4 267 2 mice mouse NNS cord-009571-mygj2nd4 267 3 do do VBP cord-009571-mygj2nd4 267 4 not not RB cord-009571-mygj2nd4 267 5 generate generate VB cord-009571-mygj2nd4 267 6 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 267 7 under under IN cord-009571-mygj2nd4 267 8 these these DT cord-009571-mygj2nd4 267 9 circumstances circumstance NNS cord-009571-mygj2nd4 267 10 . . . cord-009571-mygj2nd4 268 1 Spleen spleen NN cord-009571-mygj2nd4 268 2 cell cell NN cord-009571-mygj2nd4 268 3 suspensions suspension NNS cord-009571-mygj2nd4 268 4 of of IN cord-009571-mygj2nd4 268 5 NZB nzb NN cord-009571-mygj2nd4 268 6 mice mouse NNS cord-009571-mygj2nd4 268 7 ( ( -LRB- cord-009571-mygj2nd4 268 8 H-2d H-2d NNP cord-009571-mygj2nd4 268 9 ) ) -RRB- cord-009571-mygj2nd4 268 10 were be VBD cord-009571-mygj2nd4 268 11 cultivated cultivate VBN cord-009571-mygj2nd4 268 12 for for IN cord-009571-mygj2nd4 268 13 5 5 CD cord-009571-mygj2nd4 268 14 days day NNS cord-009571-mygj2nd4 268 15 in in IN cord-009571-mygj2nd4 268 16 the the DT cord-009571-mygj2nd4 268 17 presence presence NN cord-009571-mygj2nd4 268 18 of of IN cord-009571-mygj2nd4 268 19 irradiated irradiate VBN cord-009571-mygj2nd4 268 20 stimulator stimulator NN cord-009571-mygj2nd4 268 21 cells cell NNS cord-009571-mygj2nd4 268 22 of of IN cord-009571-mygj2nd4 268 23 other other JJ cord-009571-mygj2nd4 268 24 H-2d h-2d JJ cord-009571-mygj2nd4 268 25 strains strain NNS cord-009571-mygj2nd4 268 26 ( ( -LRB- cord-009571-mygj2nd4 268 27 B10.D2 B10.D2 NNP cord-009571-mygj2nd4 268 28 , , , cord-009571-mygj2nd4 268 29 BALB BALB NNP cord-009571-mygj2nd4 268 30 / / SYM cord-009571-mygj2nd4 268 31 c c NN cord-009571-mygj2nd4 268 32 , , , cord-009571-mygj2nd4 268 33 DBA/2 DBA/2 NNP cord-009571-mygj2nd4 268 34 , , , cord-009571-mygj2nd4 268 35 HW19 HW19 NNP cord-009571-mygj2nd4 268 36 ) ) -RRB- cord-009571-mygj2nd4 268 37 . . . cord-009571-mygj2nd4 269 1 On on IN cord-009571-mygj2nd4 269 2 the the DT cord-009571-mygj2nd4 269 3 fifth fifth JJ cord-009571-mygj2nd4 269 4 day day NN cord-009571-mygj2nd4 269 5 labeled label VBN cord-009571-mygj2nd4 269 6 target target NN cord-009571-mygj2nd4 269 7 cells cell NNS cord-009571-mygj2nd4 269 8 identical identical JJ cord-009571-mygj2nd4 269 9 to to IN cord-009571-mygj2nd4 269 10 the the DT cord-009571-mygj2nd4 269 11 stimulating stimulating JJ cord-009571-mygj2nd4 269 12 cells cell NNS cord-009571-mygj2nd4 269 13 were be VBD cord-009571-mygj2nd4 269 14 added add VBN cord-009571-mygj2nd4 269 15 and and CC cord-009571-mygj2nd4 269 16 the6'Cr the6'Cr NNP cord-009571-mygj2nd4 269 17 release release NN cord-009571-mygj2nd4 269 18 from from IN cord-009571-mygj2nd4 269 19 these these DT cord-009571-mygj2nd4 269 20 targets target NNS cord-009571-mygj2nd4 269 21 was be VBD cord-009571-mygj2nd4 269 22 measured measure VBN cord-009571-mygj2nd4 269 23 after after IN cord-009571-mygj2nd4 269 24 4 4 CD cord-009571-mygj2nd4 269 25 hours hour NNS cord-009571-mygj2nd4 269 26 . . . cord-009571-mygj2nd4 270 1 NZB NZB NNP cord-009571-mygj2nd4 270 2 effector effector NN cord-009571-mygj2nd4 270 3 cells cell NNS cord-009571-mygj2nd4 270 4 exerted exert VBD cord-009571-mygj2nd4 270 5 a a DT cord-009571-mygj2nd4 270 6 highly highly RB cord-009571-mygj2nd4 270 7 significant significant JJ cord-009571-mygj2nd4 270 8 specific specific JJ cord-009571-mygj2nd4 270 9 lysis lysis NN cord-009571-mygj2nd4 270 10 in in IN cord-009571-mygj2nd4 270 11 all all DT cord-009571-mygj2nd4 270 12 four four CD cord-009571-mygj2nd4 270 13 of of IN cord-009571-mygj2nd4 270 14 the the DT cord-009571-mygj2nd4 270 15 H-2d h-2d JJ cord-009571-mygj2nd4 270 16 strains strain NNS cord-009571-mygj2nd4 270 17 tested test VBN cord-009571-mygj2nd4 270 18 ; ; : cord-009571-mygj2nd4 270 19 none none NN cord-009571-mygj2nd4 270 20 of of IN cord-009571-mygj2nd4 270 21 these these DT cord-009571-mygj2nd4 270 22 reacted react VBD cord-009571-mygj2nd4 270 23 against against IN cord-009571-mygj2nd4 270 24 NZB nzb NN cord-009571-mygj2nd4 270 25 . . . cord-009571-mygj2nd4 271 1 In in IN cord-009571-mygj2nd4 271 2 experiments experiment NNS cord-009571-mygj2nd4 271 3 in in IN cord-009571-mygj2nd4 271 4 which which WDT cord-009571-mygj2nd4 271 5 NZB nzb NN cord-009571-mygj2nd4 271 6 cells cell NNS cord-009571-mygj2nd4 271 7 were be VBD cord-009571-mygj2nd4 271 8 sensitized sensitize VBN cord-009571-mygj2nd4 271 9 against against IN cord-009571-mygj2nd4 271 10 one one CD cord-009571-mygj2nd4 271 11 H-2d h-2d JJ cord-009571-mygj2nd4 271 12 strain strain NN cord-009571-mygj2nd4 271 13 ( ( -LRB- cord-009571-mygj2nd4 271 14 BALB BALB NNP cord-009571-mygj2nd4 271 15 / / SYM cord-009571-mygj2nd4 271 16 c c NN cord-009571-mygj2nd4 271 17 ) ) -RRB- cord-009571-mygj2nd4 271 18 target target NN cord-009571-mygj2nd4 271 19 cells cell NNS cord-009571-mygj2nd4 271 20 from from IN cord-009571-mygj2nd4 271 21 all all DT cord-009571-mygj2nd4 271 22 four four CD cord-009571-mygj2nd4 271 23 H-2d h-2d JJ cord-009571-mygj2nd4 271 24 strains strain NNS cord-009571-mygj2nd4 271 25 were be VBD cord-009571-mygj2nd4 271 26 lysed lyse VBN cord-009571-mygj2nd4 271 27 , , , cord-009571-mygj2nd4 271 28 demonstrating demonstrate VBG cord-009571-mygj2nd4 271 29 crossreactivity crossreactivity NN cord-009571-mygj2nd4 271 30 of of IN cord-009571-mygj2nd4 271 31 the the DT cord-009571-mygj2nd4 271 32 lytic lytic JJ cord-009571-mygj2nd4 271 33 reaction reaction NN cord-009571-mygj2nd4 271 34 . . . cord-009571-mygj2nd4 272 1 The the DT cord-009571-mygj2nd4 272 2 amount amount NN cord-009571-mygj2nd4 272 3 of of IN cord-009571-mygj2nd4 272 4 lysis lysis NN cord-009571-mygj2nd4 272 5 observed observe VBD cord-009571-mygj2nd4 272 6 was be VBD cord-009571-mygj2nd4 272 7 dependent dependent JJ cord-009571-mygj2nd4 272 8 on on IN cord-009571-mygj2nd4 272 9 the the DT cord-009571-mygj2nd4 272 10 ratio ratio NN cord-009571-mygj2nd4 272 11 of of IN cord-009571-mygj2nd4 272 12 effector effector NN cord-009571-mygj2nd4 272 13 to to TO cord-009571-mygj2nd4 272 14 target target NN cord-009571-mygj2nd4 272 15 cells cell NNS cord-009571-mygj2nd4 272 16 . . . cord-009571-mygj2nd4 273 1 The the DT cord-009571-mygj2nd4 273 2 action action NN cord-009571-mygj2nd4 273 3 of of IN cord-009571-mygj2nd4 273 4 the the DT cord-009571-mygj2nd4 273 5 effector effector NN cord-009571-mygj2nd4 273 6 cells cell NNS cord-009571-mygj2nd4 273 7 was be VBD cord-009571-mygj2nd4 273 8 abolished abolish VBN cord-009571-mygj2nd4 273 9 by by IN cord-009571-mygj2nd4 273 10 treatment treatment NN cord-009571-mygj2nd4 273 11 with with IN cord-009571-mygj2nd4 273 12 anti anti NNP cord-009571-mygj2nd4 273 13 - - NNP cord-009571-mygj2nd4 273 14 Thy-1 Thy-1 NNP cord-009571-mygj2nd4 273 15 serum serum NN cord-009571-mygj2nd4 273 16 , , , cord-009571-mygj2nd4 273 17 indicating indicate VBG cord-009571-mygj2nd4 273 18 their -PRON- PRP$ cord-009571-mygj2nd4 273 19 T T NNP cord-009571-mygj2nd4 273 20 cell cell NN cord-009571-mygj2nd4 273 21 character character NN cord-009571-mygj2nd4 273 22 . . . cord-009571-mygj2nd4 274 1 The the DT cord-009571-mygj2nd4 274 2 capacity capacity NN cord-009571-mygj2nd4 274 3 to to TO cord-009571-mygj2nd4 274 4 respond respond VB cord-009571-mygj2nd4 274 5 against against IN cord-009571-mygj2nd4 274 6 BALB BALB NNP cord-009571-mygj2nd4 274 7 / / SYM cord-009571-mygj2nd4 274 8 c c NN cord-009571-mygj2nd4 274 9 could could MD cord-009571-mygj2nd4 274 10 be be VB cord-009571-mygj2nd4 274 11 demonstrated demonstrate VBN cord-009571-mygj2nd4 274 12 in in IN cord-009571-mygj2nd4 274 13 NZB nzb NN cord-009571-mygj2nd4 274 14 mice mouse NNS cord-009571-mygj2nd4 274 15 as as RB cord-009571-mygj2nd4 274 16 early early RB cord-009571-mygj2nd4 274 17 as as IN cord-009571-mygj2nd4 274 18 4 4 CD cord-009571-mygj2nd4 274 19 weeks week NNS cord-009571-mygj2nd4 274 20 and and CC cord-009571-mygj2nd4 274 21 as as RB cord-009571-mygj2nd4 274 22 late late JJ cord-009571-mygj2nd4 274 23 as as IN cord-009571-mygj2nd4 274 24 16 16 CD cord-009571-mygj2nd4 274 25 months month NNS cord-009571-mygj2nd4 274 26 of of IN cord-009571-mygj2nd4 274 27 age age NN cord-009571-mygj2nd4 274 28 . . . cord-009571-mygj2nd4 275 1 The the DT cord-009571-mygj2nd4 275 2 capacity capacity NN cord-009571-mygj2nd4 275 3 of of IN cord-009571-mygj2nd4 275 4 NZB nzb NN cord-009571-mygj2nd4 275 5 mice mouse NNS cord-009571-mygj2nd4 275 6 to to TO cord-009571-mygj2nd4 275 7 generate generate VB cord-009571-mygj2nd4 275 8 cytotoxic cytotoxic JJ cord-009571-mygj2nd4 275 9 T t NN cord-009571-mygj2nd4 275 10 - - HYPH cord-009571-mygj2nd4 275 11 cells cell NNS cord-009571-mygj2nd4 275 12 following follow VBG cord-009571-mygj2nd4 275 13 primary primary JJ cord-009571-mygj2nd4 275 14 in in IN cord-009571-mygj2nd4 275 15 vitro vitro FW cord-009571-mygj2nd4 275 16 sensitization sensitization NN cord-009571-mygj2nd4 275 17 against against IN cord-009571-mygj2nd4 275 18 targets target NNS cord-009571-mygj2nd4 275 19 carrying carry VBG cord-009571-mygj2nd4 275 20 the the DT cord-009571-mygj2nd4 275 21 same same JJ cord-009571-mygj2nd4 275 22 major major JJ cord-009571-mygj2nd4 275 23 transplantation transplantation NN cord-009571-mygj2nd4 275 24 antigens antigen NNS cord-009571-mygj2nd4 275 25 as as IN cord-009571-mygj2nd4 275 26 NZB NZB NNP cord-009571-mygj2nd4 275 27 establishes establish VBZ cord-009571-mygj2nd4 275 28 a a DT cord-009571-mygj2nd4 275 29 qualitative qualitative JJ cord-009571-mygj2nd4 275 30 difference difference NN cord-009571-mygj2nd4 275 31 between between IN cord-009571-mygj2nd4 275 32 NZB nzb NN cord-009571-mygj2nd4 275 33 mice mouse NNS cord-009571-mygj2nd4 275 34 and and CC cord-009571-mygj2nd4 275 35 all all DT cord-009571-mygj2nd4 275 36 normal normal JJ cord-009571-mygj2nd4 275 37 strains strain NNS cord-009571-mygj2nd4 275 38 since since IN cord-009571-mygj2nd4 275 39 generation generation NN cord-009571-mygj2nd4 275 40 of of IN cord-009571-mygj2nd4 275 41 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 275 42 is be VBZ cord-009571-mygj2nd4 275 43 restricted restrict VBN cord-009571-mygj2nd4 275 44 under under IN cord-009571-mygj2nd4 275 45 the the DT cord-009571-mygj2nd4 275 46 applied apply VBN cord-009571-mygj2nd4 275 47 conditions condition NNS cord-009571-mygj2nd4 275 48 to to IN cord-009571-mygj2nd4 275 49 targets target NNS cord-009571-mygj2nd4 275 50 differing differ VBG cord-009571-mygj2nd4 275 51 at at IN cord-009571-mygj2nd4 275 52 the the DT cord-009571-mygj2nd4 275 53 H-2 h-2 NN cord-009571-mygj2nd4 275 54 in in IN cord-009571-mygj2nd4 275 55 all all DT cord-009571-mygj2nd4 275 56 normal normal JJ cord-009571-mygj2nd4 275 57 strains strain NNS cord-009571-mygj2nd4 275 58 heretofore heretofore RB cord-009571-mygj2nd4 275 59 tested test VBN cord-009571-mygj2nd4 275 60 . . . cord-009571-mygj2nd4 276 1 It -PRON- PRP cord-009571-mygj2nd4 276 2 is be VBZ cord-009571-mygj2nd4 276 3 suggested suggest VBN cord-009571-mygj2nd4 276 4 that that IN cord-009571-mygj2nd4 276 5 the the DT cord-009571-mygj2nd4 276 6 observed observed JJ cord-009571-mygj2nd4 276 7 lack lack NN cord-009571-mygj2nd4 276 8 of of IN cord-009571-mygj2nd4 276 9 restrictioq restrictioq NN cord-009571-mygj2nd4 276 10 of of IN cord-009571-mygj2nd4 276 11 the the DT cord-009571-mygj2nd4 276 12 cytotoxic cytotoxic JJ cord-009571-mygj2nd4 276 13 reaction reaction NN cord-009571-mygj2nd4 276 14 in in IN cord-009571-mygj2nd4 276 15 NZB nzb NN cord-009571-mygj2nd4 276 16 mice mouse NNS cord-009571-mygj2nd4 276 17 is be VBZ cord-009571-mygj2nd4 276 18 related relate VBN cord-009571-mygj2nd4 276 19 to to IN cord-009571-mygj2nd4 276 20 the the DT cord-009571-mygj2nd4 276 21 autoimmune autoimmune JJ cord-009571-mygj2nd4 276 22 reactivity reactivity NN cord-009571-mygj2nd4 276 23 of of IN cord-009571-mygj2nd4 276 24 this this DT cord-009571-mygj2nd4 276 25 strain strain NN cord-009571-mygj2nd4 276 26 . . . cord-009571-mygj2nd4 276 27 _SP cord-009571-mygj2nd4 277 1 Immune immune JJ cord-009571-mygj2nd4 277 2 deposits deposit NNS cord-009571-mygj2nd4 277 3 in in IN cord-009571-mygj2nd4 277 4 the the DT cord-009571-mygj2nd4 277 5 choroid choroid JJ cord-009571-mygj2nd4 277 6 plexus plexus NN cord-009571-mygj2nd4 277 7 of of IN cord-009571-mygj2nd4 277 8 patients patient NNS cord-009571-mygj2nd4 277 9 with with IN cord-009571-mygj2nd4 277 10 neuropsychiatric neuropsychiatric JJ cord-009571-mygj2nd4 277 11 manifestations manifestation NNS cord-009571-mygj2nd4 277 12 of of IN cord-009571-mygj2nd4 277 13 systemic systemic JJ cord-009571-mygj2nd4 277 14 lupus lupus NN cord-009571-mygj2nd4 277 15 erythematosus erythematosus NN cord-009571-mygj2nd4 277 16 ( ( -LRB- cord-009571-mygj2nd4 277 17 SLE SLE NNP cord-009571-mygj2nd4 277 18 ) ) -RRB- cord-009571-mygj2nd4 277 19 and and CC cord-009571-mygj2nd4 277 20 NZB NZB NNP cord-009571-mygj2nd4 277 21 / / SYM cord-009571-mygj2nd4 277 22 NZW NZW NNP cord-009571-mygj2nd4 277 23 F F NNP cord-009571-mygj2nd4 277 24 , , , cord-009571-mygj2nd4 277 25 hybrid hybrid JJ cord-009571-mygj2nd4 277 26 mice mouse NNS cord-009571-mygj2nd4 277 27 are be VBP cord-009571-mygj2nd4 277 28 thought think VBN cord-009571-mygj2nd4 277 29 to to TO cord-009571-mygj2nd4 277 30 relate relate VB cord-009571-mygj2nd4 277 31 to to IN cord-009571-mygj2nd4 277 32 the the DT cord-009571-mygj2nd4 277 33 pathogenesis pathogenesis NN cord-009571-mygj2nd4 277 34 of of IN cord-009571-mygj2nd4 277 35 central central JJ cord-009571-mygj2nd4 277 36 nervous nervous JJ cord-009571-mygj2nd4 277 37 system system NN cord-009571-mygj2nd4 277 38 ( ( -LRB- cord-009571-mygj2nd4 277 39 CNS CNS NNP cord-009571-mygj2nd4 277 40 ) ) -RRB- cord-009571-mygj2nd4 277 41 lupus lupus NN cord-009571-mygj2nd4 277 42 . . . cord-009571-mygj2nd4 278 1 Since since IN cord-009571-mygj2nd4 278 2 previous previous JJ cord-009571-mygj2nd4 278 3 studies study NNS cord-009571-mygj2nd4 278 4 did do VBD cord-009571-mygj2nd4 278 5 not not RB cord-009571-mygj2nd4 278 6 include include VB cord-009571-mygj2nd4 278 7 in in IN cord-009571-mygj2nd4 278 8 their -PRON- PRP$ cord-009571-mygj2nd4 278 9 control control NN cord-009571-mygj2nd4 278 10 groups group NNS cord-009571-mygj2nd4 278 11 patients patient NNS cord-009571-mygj2nd4 278 12 with with IN cord-009571-mygj2nd4 278 13 SLE SLE NNP cord-009571-mygj2nd4 278 14 who who WP cord-009571-mygj2nd4 278 15 had have VBD cord-009571-mygj2nd4 278 16 no no DT cord-009571-mygj2nd4 278 17 neuropsychiatric neuropsychiatric JJ cord-009571-mygj2nd4 278 18 manifestations manifestation NNS cord-009571-mygj2nd4 278 19 , , , cord-009571-mygj2nd4 278 20 we -PRON- PRP cord-009571-mygj2nd4 278 21 looked look VBD cord-009571-mygj2nd4 278 22 for for IN cord-009571-mygj2nd4 278 23 immune immune JJ cord-009571-mygj2nd4 278 24 deposits deposit NNS cord-009571-mygj2nd4 278 25 in in IN cord-009571-mygj2nd4 278 26 the the DT cord-009571-mygj2nd4 278 27 choroid choroid JJ cord-009571-mygj2nd4 278 28 tissue tissue NN cord-009571-mygj2nd4 278 29 of of IN cord-009571-mygj2nd4 278 30 patients patient NNS cord-009571-mygj2nd4 278 31 with with IN cord-009571-mygj2nd4 278 32 and and CC cord-009571-mygj2nd4 278 33 without without IN cord-009571-mygj2nd4 278 34 CNS CNS NNP cord-009571-mygj2nd4 278 35 lupus lupus NN cord-009571-mygj2nd4 278 36 . . . cord-009571-mygj2nd4 279 1 Fixed fix VBN cord-009571-mygj2nd4 279 2 brain brain NN cord-009571-mygj2nd4 279 3 tissue tissue NN cord-009571-mygj2nd4 279 4 containing contain VBG cord-009571-mygj2nd4 279 5 choroid choroid JJ cord-009571-mygj2nd4 279 6 plexus plexus NN cord-009571-mygj2nd4 279 7 was be VBD cord-009571-mygj2nd4 279 8 retrieved retrieve VBN cord-009571-mygj2nd4 279 9 from from IN cord-009571-mygj2nd4 279 10 6 6 CD cord-009571-mygj2nd4 279 11 SLE SLE NNP cord-009571-mygj2nd4 279 12 patients patient NNS cord-009571-mygj2nd4 279 13 and and CC cord-009571-mygj2nd4 279 14 3 3 CD cord-009571-mygj2nd4 279 15 cont.rols cont.rol NNS cord-009571-mygj2nd4 279 16 . . . cord-009571-mygj2nd4 280 1 Ependymal Ependymal NNP cord-009571-mygj2nd4 280 2 lining lining NN cord-009571-mygj2nd4 280 3 cells cell NNS cord-009571-mygj2nd4 280 4 , , , cord-009571-mygj2nd4 280 5 choroid choroid JJ cord-009571-mygj2nd4 280 6 stroma stroma NN cord-009571-mygj2nd4 280 7 , , , cord-009571-mygj2nd4 280 8 and and CC cord-009571-mygj2nd4 280 9 cortical cortical JJ cord-009571-mygj2nd4 280 10 vessels vessel NNS cord-009571-mygj2nd4 280 11 were be VBD cord-009571-mygj2nd4 280 12 reviewed review VBN cord-009571-mygj2nd4 280 13 for for IN cord-009571-mygj2nd4 280 14 deposits deposit NNS cord-009571-mygj2nd4 280 15 of of IN cord-009571-mygj2nd4 280 16 IgG IgG NNP cord-009571-mygj2nd4 280 17 , , , cord-009571-mygj2nd4 280 18 IgM IgM NNP cord-009571-mygj2nd4 280 19 , , , cord-009571-mygj2nd4 280 20 IgA IgA NNP cord-009571-mygj2nd4 280 21 , , , cord-009571-mygj2nd4 280 22 IgD IgD NNP cord-009571-mygj2nd4 280 23 , , , cord-009571-mygj2nd4 280 24 IgE IgE NNP cord-009571-mygj2nd4 280 25 , , , cord-009571-mygj2nd4 280 26 and and CC cord-009571-mygj2nd4 280 27 kappa kappa NNP cord-009571-mygj2nd4 280 28 and and CC cord-009571-mygj2nd4 280 29 lambda lambda NNP cord-009571-mygj2nd4 280 30 light light JJ cord-009571-mygj2nd4 280 31 chains chain NNS cord-009571-mygj2nd4 280 32 by by IN cord-009571-mygj2nd4 280 33 an an DT cord-009571-mygj2nd4 280 34 immunoperoxidase immunoperoxidase NN cord-009571-mygj2nd4 280 35 technique technique NN cord-009571-mygj2nd4 280 36 ( ( -LRB- cord-009571-mygj2nd4 280 37 rabbit rabbit NN cord-009571-mygj2nd4 280 38 antihuman antihuman NN cord-009571-mygj2nd4 280 39 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 280 40 and and CC cord-009571-mygj2nd4 280 41 peroxidase peroxidase NN cord-009571-mygj2nd4 280 42 - - HYPH cord-009571-mygj2nd4 280 43 antiperoxidase antiperoxidase NN cord-009571-mygj2nd4 280 44 ) ) -RRB- cord-009571-mygj2nd4 280 45 . . . cord-009571-mygj2nd4 281 1 Complement complement JJ cord-009571-mygj2nd4 281 2 components component NNS cord-009571-mygj2nd4 281 3 were be VBD cord-009571-mygj2nd4 281 4 destroyed destroy VBN cord-009571-mygj2nd4 281 5 by by IN cord-009571-mygj2nd4 281 6 fixation fixation NN cord-009571-mygj2nd4 281 7 . . . cord-009571-mygj2nd4 282 1 Immunoglobulins Immunoglobulins NNP cord-009571-mygj2nd4 282 2 and and CC cord-009571-mygj2nd4 282 3 light light JJ cord-009571-mygj2nd4 282 4 chains chain NNS cord-009571-mygj2nd4 282 5 were be VBD cord-009571-mygj2nd4 282 6 found find VBN cord-009571-mygj2nd4 282 7 in in IN cord-009571-mygj2nd4 282 8 the the DT cord-009571-mygj2nd4 282 9 ependymal ependymal JJ cord-009571-mygj2nd4 282 10 cells cell NNS cord-009571-mygj2nd4 282 11 and/or and/or CC cord-009571-mygj2nd4 282 12 choroid choroid JJ cord-009571-mygj2nd4 282 13 stroma stroma NN cord-009571-mygj2nd4 282 14 of of IN cord-009571-mygj2nd4 282 15 each each DT cord-009571-mygj2nd4 282 16 SLE SLE NNP cord-009571-mygj2nd4 282 17 patient patient NN cord-009571-mygj2nd4 282 18 . . . cord-009571-mygj2nd4 283 1 The the DT cord-009571-mygj2nd4 283 2 pattern pattern NN cord-009571-mygj2nd4 283 3 or or CC cord-009571-mygj2nd4 283 4 intensity intensity NN cord-009571-mygj2nd4 283 5 of of IN cord-009571-mygj2nd4 283 6 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 283 7 deposition deposition NN cord-009571-mygj2nd4 283 8 did do VBD cord-009571-mygj2nd4 283 9 not not RB cord-009571-mygj2nd4 283 10 distinguish distinguish VB cord-009571-mygj2nd4 283 11 those those DT cord-009571-mygj2nd4 283 12 patients patient NNS cord-009571-mygj2nd4 283 13 with with IN cord-009571-mygj2nd4 283 14 and and CC cord-009571-mygj2nd4 283 15 without without IN cord-009571-mygj2nd4 283 16 neuropsychiatric neuropsychiatric JJ cord-009571-mygj2nd4 283 17 manifestations manifestation NNS cord-009571-mygj2nd4 283 18 . . . cord-009571-mygj2nd4 284 1 No no DT cord-009571-mygj2nd4 284 2 staining staining NN cord-009571-mygj2nd4 284 3 was be VBD cord-009571-mygj2nd4 284 4 seen see VBN cord-009571-mygj2nd4 284 5 in in IN cord-009571-mygj2nd4 284 6 tissue tissue NN cord-009571-mygj2nd4 284 7 from from IN cord-009571-mygj2nd4 284 8 the the DT cord-009571-mygj2nd4 284 9 controls control NNS cord-009571-mygj2nd4 284 10 . . . cord-009571-mygj2nd4 285 1 Though though IN cord-009571-mygj2nd4 285 2 the the DT cord-009571-mygj2nd4 285 3 choroid choroid JJ cord-009571-mygj2nd4 285 4 plexus plexus NN cord-009571-mygj2nd4 285 5 serves serve VBZ cord-009571-mygj2nd4 285 6 a a DT cord-009571-mygj2nd4 285 7 filtering filtering NN cord-009571-mygj2nd4 285 8 function function NN cord-009571-mygj2nd4 285 9 , , , cord-009571-mygj2nd4 285 10 the the DT cord-009571-mygj2nd4 285 11 finding finding NN cord-009571-mygj2nd4 285 12 of of IN cord-009571-mygj2nd4 285 13 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 285 14 deposits deposit NNS cord-009571-mygj2nd4 285 15 in in IN cord-009571-mygj2nd4 285 16 the the DT cord-009571-mygj2nd4 285 17 choroid choroid JJ cord-009571-mygj2nd4 285 18 plexus plexus NN cord-009571-mygj2nd4 285 19 can can MD cord-009571-mygj2nd4 285 20 not not RB cord-009571-mygj2nd4 285 21 be be VB cord-009571-mygj2nd4 285 22 correlated correlate VBN cord-009571-mygj2nd4 285 23 specifically specifically RB cord-009571-mygj2nd4 285 24 with with IN cord-009571-mygj2nd4 285 25 any any DT cord-009571-mygj2nd4 285 26 of of IN cord-009571-mygj2nd4 285 27 the the DT cord-009571-mygj2nd4 285 28 diverse diverse JJ cord-009571-mygj2nd4 285 29 manifestations manifestation NNS cord-009571-mygj2nd4 285 30 of of IN cord-009571-mygj2nd4 285 31 CNS CNS NNP cord-009571-mygj2nd4 285 32 lupus lupus NN cord-009571-mygj2nd4 285 33 . . . cord-009571-mygj2nd4 286 1 Other other JJ cord-009571-mygj2nd4 286 2 clinicopathologic clinicopathologic JJ cord-009571-mygj2nd4 286 3 correlations correlation NNS cord-009571-mygj2nd4 286 4 must must MD cord-009571-mygj2nd4 286 5 be be VB cord-009571-mygj2nd4 286 6 sought seek VBN cord-009571-mygj2nd4 286 7 . . . cord-009571-mygj2nd4 287 1 Multinucleate Multinucleate NNP cord-009571-mygj2nd4 287 2 cells cell NNS cord-009571-mygj2nd4 287 3 ( ( -LRB- cord-009571-mygj2nd4 287 4 heterokaryons heterokaryon NNS cord-009571-mygj2nd4 287 5 ) ) -RRB- cord-009571-mygj2nd4 287 6 are be VBP cord-009571-mygj2nd4 287 7 frequently frequently RB cord-009571-mygj2nd4 287 8 found find VBN cord-009571-mygj2nd4 287 9 in in IN cord-009571-mygj2nd4 287 10 rheumatoid rheumatoid NN cord-009571-mygj2nd4 287 11 synovium synovium NN cord-009571-mygj2nd4 287 12 as as RB cord-009571-mygj2nd4 287 13 well well RB cord-009571-mygj2nd4 287 14 as as IN cord-009571-mygj2nd4 287 15 in in IN cord-009571-mygj2nd4 287 16 cultures culture NNS cord-009571-mygj2nd4 287 17 of of IN cord-009571-mygj2nd4 287 18 isolated isolate VBN cord-009571-mygj2nd4 287 19 , , , cord-009571-mygj2nd4 287 20 adherent adherent JJ cord-009571-mygj2nd4 287 21 cells cell NNS cord-009571-mygj2nd4 287 22 from from IN cord-009571-mygj2nd4 287 23 this this DT cord-009571-mygj2nd4 287 24 tissue tissue NN cord-009571-mygj2nd4 287 25 . . . cord-009571-mygj2nd4 288 1 Using use VBG cord-009571-mygj2nd4 288 2 an an DT cord-009571-mygj2nd4 288 3 experimental experimental JJ cord-009571-mygj2nd4 288 4 Polyethylene polyethylene NN cord-009571-mygj2nd4 288 5 glycol glycol NN cord-009571-mygj2nd4 288 6 ( ( -LRB- cord-009571-mygj2nd4 288 7 PEG PEG NNP cord-009571-mygj2nd4 288 8 ) ) -RRB- cord-009571-mygj2nd4 288 9 was be VBD cord-009571-mygj2nd4 288 10 used use VBN cord-009571-mygj2nd4 288 11 to to TO cord-009571-mygj2nd4 288 12 fuse fuse VB cord-009571-mygj2nd4 288 13 cells cell NNS cord-009571-mygj2nd4 288 14 in in IN cord-009571-mygj2nd4 288 15 monolayer monolayer NN cord-009571-mygj2nd4 288 16 cultures culture NNS cord-009571-mygj2nd4 288 17 of of IN cord-009571-mygj2nd4 288 18 rabbit rabbit NN cord-009571-mygj2nd4 288 19 synovial synovial JJ cord-009571-mygj2nd4 288 20 fibroblasts fibroblast NNS cord-009571-mygj2nd4 288 21 . . . cord-009571-mygj2nd4 289 1 Fusion fusion NN cord-009571-mygj2nd4 289 2 began begin VBD cord-009571-mygj2nd4 289 3 within within IN cord-009571-mygj2nd4 289 4 30 30 CD cord-009571-mygj2nd4 289 5 minutes minute NNS cord-009571-mygj2nd4 289 6 of of IN cord-009571-mygj2nd4 289 7 PEG PEG NNP cord-009571-mygj2nd4 289 8 treatment treatment NN cord-009571-mygj2nd4 289 9 and and CC cord-009571-mygj2nd4 289 10 continued continue VBD cord-009571-mygj2nd4 289 11 for for IN cord-009571-mygj2nd4 289 12 about about RB cord-009571-mygj2nd4 289 13 4 4 CD cord-009571-mygj2nd4 289 14 hours hour NNS cord-009571-mygj2nd4 289 15 ; ; : cord-009571-mygj2nd4 289 16 approximately approximately RB cord-009571-mygj2nd4 289 17 40 40 CD cord-009571-mygj2nd4 289 18 % % NN cord-009571-mygj2nd4 289 19 of of IN cord-009571-mygj2nd4 289 20 the the DT cord-009571-mygj2nd4 289 21 cells cell NNS cord-009571-mygj2nd4 289 22 developed develop VBD cord-009571-mygj2nd4 289 23 2 2 CD cord-009571-mygj2nd4 289 24 or or CC cord-009571-mygj2nd4 289 25 more more JJR cord-009571-mygj2nd4 289 26 nuclei nucleus NNS cord-009571-mygj2nd4 289 27 . . . cord-009571-mygj2nd4 290 1 In in IN cord-009571-mygj2nd4 290 2 some some DT cord-009571-mygj2nd4 290 3 experiments experiment NNS cord-009571-mygj2nd4 290 4 , , , cord-009571-mygj2nd4 290 5 up up IN cord-009571-mygj2nd4 290 6 to to TO cord-009571-mygj2nd4 290 7 30 30 CD cord-009571-mygj2nd4 290 8 % % NN cord-009571-mygj2nd4 290 9 of of IN cord-009571-mygj2nd4 290 10 fused fuse VBN cord-009571-mygj2nd4 290 11 cells cell NNS cord-009571-mygj2nd4 290 12 contained contain VBD cord-009571-mygj2nd4 290 13 6 6 CD cord-009571-mygj2nd4 290 14 or or CC cord-009571-mygj2nd4 290 15 more more JJR cord-009571-mygj2nd4 290 16 nuclei nucleus NNS cord-009571-mygj2nd4 290 17 , , , cord-009571-mygj2nd4 290 18 indicating indicate VBG cord-009571-mygj2nd4 290 19 true true JJ cord-009571-mygj2nd4 290 20 giant giant JJ cord-009571-mygj2nd4 290 21 cell cell NN cord-009571-mygj2nd4 290 22 formation formation NN cord-009571-mygj2nd4 290 23 . . . cord-009571-mygj2nd4 291 1 Measurement Measurement NNP cord-009571-mygj2nd4 291 2 of of IN cord-009571-mygj2nd4 291 3 intracelluar intracelluar NNP cord-009571-mygj2nd4 291 4 ( ( -LRB- cord-009571-mygj2nd4 291 5 86 86 CD cord-009571-mygj2nd4 291 6 rubidium rubidium NN cord-009571-mygj2nd4 291 7 ) ) -RRB- cord-009571-mygj2nd4 291 8 to to TO cord-009571-mygj2nd4 291 9 indicate indicate VB cord-009571-mygj2nd4 291 10 the the DT cord-009571-mygj2nd4 291 11 presence presence NN cord-009571-mygj2nd4 291 12 of of IN cord-009571-mygj2nd4 291 13 a a DT cord-009571-mygj2nd4 291 14 leaky leaky JJ cord-009571-mygj2nd4 291 15 cell cell NN cord-009571-mygj2nd4 291 16 membrane membrane NN cord-009571-mygj2nd4 291 17 showed show VBD cord-009571-mygj2nd4 291 18 that that IN cord-009571-mygj2nd4 291 19 immediately immediately RB cord-009571-mygj2nd4 291 20 after after IN cord-009571-mygj2nd4 291 21 PEG peg NN cord-009571-mygj2nd4 291 22 treatment treatment NN cord-009571-mygj2nd4 291 23 , , , cord-009571-mygj2nd4 291 24 intracellular intracellular JJ cord-009571-mygj2nd4 291 25 ( ( -LRB- cord-009571-mygj2nd4 291 26 86 86 CD cord-009571-mygj2nd4 291 27 Rb+ Rb+ NNP cord-009571-mygj2nd4 291 28 ) ) -RRB- cord-009571-mygj2nd4 291 29 dropped drop VBD cord-009571-mygj2nd4 291 30 to to IN cord-009571-mygj2nd4 291 31 30 30 CD cord-009571-mygj2nd4 291 32 % % NN cord-009571-mygj2nd4 291 33 of of IN cord-009571-mygj2nd4 291 34 control control NN cord-009571-mygj2nd4 291 35 levels level NNS cord-009571-mygj2nd4 291 36 . . . cord-009571-mygj2nd4 292 1 It -PRON- PRP cord-009571-mygj2nd4 292 2 began begin VBD cord-009571-mygj2nd4 292 3 to to TO cord-009571-mygj2nd4 292 4 approach approach VB cord-009571-mygj2nd4 292 5 normal normal JJ cord-009571-mygj2nd4 292 6 by by IN cord-009571-mygj2nd4 292 7 5 5 CD cord-009571-mygj2nd4 292 8 minutes minute NNS cord-009571-mygj2nd4 292 9 but but CC cord-009571-mygj2nd4 292 10 did do VBD cord-009571-mygj2nd4 292 11 not not RB cord-009571-mygj2nd4 292 12 recover recover VB cord-009571-mygj2nd4 292 13 fully fully RB cord-009571-mygj2nd4 292 14 for for IN cord-009571-mygj2nd4 292 15 about about RB cord-009571-mygj2nd4 292 16 4 4 CD cord-009571-mygj2nd4 292 17 hours hour NNS cord-009571-mygj2nd4 292 18 , , , cord-009571-mygj2nd4 292 19 at at IN cord-009571-mygj2nd4 292 20 completion completion NN cord-009571-mygj2nd4 292 21 of of IN cord-009571-mygj2nd4 292 22 fusion fusion NN cord-009571-mygj2nd4 292 23 . . . cord-009571-mygj2nd4 293 1 During during IN cord-009571-mygj2nd4 293 2 the the DT cord-009571-mygj2nd4 293 3 first first JJ cord-009571-mygj2nd4 293 4 24 24 CD cord-009571-mygj2nd4 293 5 hours hour NNS cord-009571-mygj2nd4 293 6 after after IN cord-009571-mygj2nd4 293 7 PEG peg NN cord-009571-mygj2nd4 293 8 treatment treatment NN cord-009571-mygj2nd4 293 9 , , , cord-009571-mygj2nd4 293 10 the the DT cord-009571-mygj2nd4 293 11 treated treat VBN cord-009571-mygj2nd4 293 12 cultures culture NNS cord-009571-mygj2nd4 293 13 incorporated incorporate VBD cord-009571-mygj2nd4 293 14 1/5 1/5 CD cord-009571-mygj2nd4 293 15 as as RB cord-009571-mygj2nd4 293 16 much much JJ cord-009571-mygj2nd4 293 17 ( ( -LRB- cord-009571-mygj2nd4 293 18 3H 3H NNP cord-009571-mygj2nd4 293 19 ) ) -RRB- cord-009571-mygj2nd4 293 20 thymidine thymidine NN cord-009571-mygj2nd4 293 21 as as IN cord-009571-mygj2nd4 293 22 did do VBD cord-009571-mygj2nd4 293 23 control control NN cord-009571-mygj2nd4 293 24 cultures culture NNS cord-009571-mygj2nd4 293 25 , , , cord-009571-mygj2nd4 293 26 but but CC cord-009571-mygj2nd4 293 27 incorporation incorporation NN cord-009571-mygj2nd4 293 28 of of IN cord-009571-mygj2nd4 293 29 ( ( -LRB- cord-009571-mygj2nd4 293 30 3H 3H NNP cord-009571-mygj2nd4 293 31 ) ) -RRB- cord-009571-mygj2nd4 293 32 leucine leucine NN cord-009571-mygj2nd4 293 33 into into IN cord-009571-mygj2nd4 293 34 TCA TCA NNP cord-009571-mygj2nd4 293 35 - - HYPH cord-009571-mygj2nd4 293 36 precipitable precipitable JJ cord-009571-mygj2nd4 293 37 radioactivity radioactivity NN cord-009571-mygj2nd4 293 38 was be VBD cord-009571-mygj2nd4 293 39 unaffected unaffected JJ cord-009571-mygj2nd4 293 40 . . . cord-009571-mygj2nd4 294 1 Autoradiographic Autoradiographic NNP cord-009571-mygj2nd4 294 2 studies study NNS cord-009571-mygj2nd4 295 1 using use VBG cord-009571-mygj2nd4 295 2 ( ( -LRB- cord-009571-mygj2nd4 295 3 3H 3H NNP cord-009571-mygj2nd4 295 4 ) ) -RRB- cord-009571-mygj2nd4 295 5 thymidine thymidine NN cord-009571-mygj2nd4 295 6 revealed reveal VBD cord-009571-mygj2nd4 295 7 that that IN cord-009571-mygj2nd4 295 8 PEG PEG NNP cord-009571-mygj2nd4 295 9 depressed depressed JJ cord-009571-mygj2nd4 295 10 incorporation incorporation NN cord-009571-mygj2nd4 295 11 of of IN cord-009571-mygj2nd4 295 12 the the DT cord-009571-mygj2nd4 295 13 label label NN cord-009571-mygj2nd4 295 14 into into IN cord-009571-mygj2nd4 295 15 DNA DNA NNP cord-009571-mygj2nd4 295 16 for for IN cord-009571-mygj2nd4 295 17 at at RB cord-009571-mygj2nd4 295 18 least least JJS cord-009571-mygj2nd4 295 19 4 4 CD cord-009571-mygj2nd4 295 20 days day NNS cord-009571-mygj2nd4 295 21 . . . cord-009571-mygj2nd4 296 1 Secretion secretion NN cord-009571-mygj2nd4 296 2 of of IN cord-009571-mygj2nd4 296 3 proteinases proteinase NNS cord-009571-mygj2nd4 296 4 from from IN cord-009571-mygj2nd4 296 5 PEG peg NN cord-009571-mygj2nd4 296 6 - - HYPH cord-009571-mygj2nd4 296 7 treated treat VBN cord-009571-mygj2nd4 296 8 and and CC cord-009571-mygj2nd4 296 9 control control NN cord-009571-mygj2nd4 296 10 cultures culture NNS cord-009571-mygj2nd4 296 11 in in IN cord-009571-mygj2nd4 296 12 serum serum NN cord-009571-mygj2nd4 296 13 - - HYPH cord-009571-mygj2nd4 296 14 free free JJ cord-009571-mygj2nd4 296 15 Dulbecco Dulbecco NNP cord-009571-mygj2nd4 296 16 's 's POS cord-009571-mygj2nd4 296 17 modified modify VBN cord-009571-mygj2nd4 296 18 Eagle Eagle NNP cord-009571-mygj2nd4 296 19 's 's POS cord-009571-mygj2nd4 296 20 medium medium NN cord-009571-mygj2nd4 296 21 was be VBD cord-009571-mygj2nd4 296 22 compared compare VBN cord-009571-mygj2nd4 296 23 . . . cord-009571-mygj2nd4 297 1 PEG peg NN cord-009571-mygj2nd4 297 2 - - HYPH cord-009571-mygj2nd4 297 3 treated treat VBN cord-009571-mygj2nd4 297 4 cultures culture NNS cord-009571-mygj2nd4 297 5 containing contain VBG cord-009571-mygj2nd4 297 6 multinucleate multinucleate NNP cord-009571-mygj2nd4 297 7 cells cell NNS cord-009571-mygj2nd4 297 8 secreted secrete VBD cord-009571-mygj2nd4 297 9 3180 3180 CD cord-009571-mygj2nd4 297 10 U U NNP cord-009571-mygj2nd4 297 11 ( ( -LRB- cord-009571-mygj2nd4 297 12 cumulative cumulative JJ cord-009571-mygj2nd4 297 13 ) ) -RRB- cord-009571-mygj2nd4 297 14 latent latent JJ cord-009571-mygj2nd4 297 15 collagenase collagenase NN cord-009571-mygj2nd4 297 16 into into IN cord-009571-mygj2nd4 297 17 medium medium NN cord-009571-mygj2nd4 297 18 changed change VBD cord-009571-mygj2nd4 297 19 every every DT cord-009571-mygj2nd4 297 20 72 72 CD cord-009571-mygj2nd4 297 21 hours hour NNS cord-009571-mygj2nd4 297 22 over over IN cord-009571-mygj2nd4 297 23 28 28 CD cord-009571-mygj2nd4 297 24 days day NNS cord-009571-mygj2nd4 297 25 , , , cord-009571-mygj2nd4 297 26 compared compare VBN cord-009571-mygj2nd4 297 27 with with IN cord-009571-mygj2nd4 297 28 279 279 CD cord-009571-mygj2nd4 297 29 U u NN cord-009571-mygj2nd4 297 30 produced produce VBN cord-009571-mygj2nd4 297 31 by by IN cord-009571-mygj2nd4 297 32 control control NN cord-009571-mygj2nd4 297 33 cells cell NNS cord-009571-mygj2nd4 297 34 during during IN cord-009571-mygj2nd4 297 35 the the DT cord-009571-mygj2nd4 297 36 same same JJ cord-009571-mygj2nd4 297 37 period period NN cord-009571-mygj2nd4 297 38 ( ( -LRB- cord-009571-mygj2nd4 297 39 1 1 CD cord-009571-mygj2nd4 297 40 U U NNP cord-009571-mygj2nd4 297 41 collagenase collagenase NNP cord-009571-mygj2nd4 297 42 degraded degrade VBD cord-009571-mygj2nd4 297 43 1 1 CD cord-009571-mygj2nd4 297 44 kg kg NN cord-009571-mygj2nd4 297 45 collagen collagen NN cord-009571-mygj2nd4 297 46 / / SYM cord-009571-mygj2nd4 297 47 hour hour NN cord-009571-mygj2nd4 297 48 at at IN cord-009571-mygj2nd4 297 49 37 37 CD cord-009571-mygj2nd4 297 50 ° ° NN cord-009571-mygj2nd4 297 51 C c NN cord-009571-mygj2nd4 297 52 . . . cord-009571-mygj2nd4 298 1 Collagenase Collagenase NNP cord-009571-mygj2nd4 298 2 was be VBD cord-009571-mygj2nd4 298 3 activated activate VBN cord-009571-mygj2nd4 298 4 from from IN cord-009571-mygj2nd4 298 5 its -PRON- PRP$ cord-009571-mygj2nd4 298 6 latent latent JJ cord-009571-mygj2nd4 298 7 precursor precursor NN cord-009571-mygj2nd4 298 8 form form NN cord-009571-mygj2nd4 298 9 by by IN cord-009571-mygj2nd4 298 10 TPCK TPCK NNP cord-009571-mygj2nd4 298 11 trypsin trypsin NN cord-009571-mygj2nd4 298 12 - - HYPH cord-009571-mygj2nd4 298 13 I0 i0 NN cord-009571-mygj2nd4 298 14 wg wg NNP cord-009571-mygj2nd4 298 15 / / SYM cord-009571-mygj2nd4 298 16 ml ml NNS cord-009571-mygj2nd4 298 17 , , , cord-009571-mygj2nd4 298 18 30 30 CD cord-009571-mygj2nd4 298 19 minutes minute NNS cord-009571-mygj2nd4 298 20 , , , cord-009571-mygj2nd4 298 21 25OC 25oc CD cord-009571-mygj2nd4 298 22 , , , cord-009571-mygj2nd4 298 23 followed follow VBN cord-009571-mygj2nd4 298 24 by by IN cord-009571-mygj2nd4 298 25 addition addition NN cord-009571-mygj2nd4 298 26 of of IN cord-009571-mygj2nd4 298 27 excess excess JJ cord-009571-mygj2nd4 298 28 soybean soybean NN cord-009571-mygj2nd4 298 29 trypsin trypsin NN cord-009571-mygj2nd4 298 30 inhibitor inhibitor NN cord-009571-mygj2nd4 298 31 . . . cord-009571-mygj2nd4 298 32 ) ) -RRB- cord-009571-mygj2nd4 299 1 Neither neither CC cord-009571-mygj2nd4 299 2 PEG peg NN cord-009571-mygj2nd4 299 3 - - HYPH cord-009571-mygj2nd4 299 4 treated treat VBN cord-009571-mygj2nd4 299 5 nor nor CC cord-009571-mygj2nd4 299 6 control control NN cord-009571-mygj2nd4 299 7 cells cell NNS cord-009571-mygj2nd4 299 8 released release VBN cord-009571-mygj2nd4 299 9 substantial substantial JJ cord-009571-mygj2nd4 299 10 or or CC cord-009571-mygj2nd4 299 11 significantly significantly RB cord-009571-mygj2nd4 299 12 different different JJ cord-009571-mygj2nd4 299 13 amounts amount NNS cord-009571-mygj2nd4 299 14 of of IN cord-009571-mygj2nd4 299 15 neutral neutral JJ cord-009571-mygj2nd4 299 16 or or CC cord-009571-mygj2nd4 299 17 acid acid JJ cord-009571-mygj2nd4 299 18 proteinases proteinase NNS cord-009571-mygj2nd4 299 19 into into IN cord-009571-mygj2nd4 299 20 medium medium NN cord-009571-mygj2nd4 299 21 during during IN cord-009571-mygj2nd4 299 22 the the DT cord-009571-mygj2nd4 299 23 same same JJ cord-009571-mygj2nd4 299 24 period period NN cord-009571-mygj2nd4 299 25 . . . cord-009571-mygj2nd4 300 1 Our -PRON- PRP$ cord-009571-mygj2nd4 300 2 data datum NNS cord-009571-mygj2nd4 300 3 show show VBP cord-009571-mygj2nd4 300 4 that that IN cord-009571-mygj2nd4 300 5 compared compare VBD cord-009571-mygj2nd4 300 6 to to IN cord-009571-mygj2nd4 300 7 controls control NNS cord-009571-mygj2nd4 300 8 , , , cord-009571-mygj2nd4 300 9 cultures culture NNS cord-009571-mygj2nd4 300 10 of of IN cord-009571-mygj2nd4 300 11 multinucleated multinucleate VBN cord-009571-mygj2nd4 300 12 cells cell NNS cord-009571-mygj2nd4 300 13 have have VBP cord-009571-mygj2nd4 300 14 a a DT cord-009571-mygj2nd4 300 15 decreased decrease VBN cord-009571-mygj2nd4 300 16 rate rate NN cord-009571-mygj2nd4 300 17 of of IN cord-009571-mygj2nd4 300 18 cell cell NN cord-009571-mygj2nd4 300 19 replication replication NN cord-009571-mygj2nd4 300 20 and and CC cord-009571-mygj2nd4 300 21 increased increase VBN cord-009571-mygj2nd4 300 22 rate rate NN cord-009571-mygj2nd4 300 23 of of IN cord-009571-mygj2nd4 300 24 collagenase collagenase NN cord-009571-mygj2nd4 300 25 production production NN cord-009571-mygj2nd4 300 26 . . . cord-009571-mygj2nd4 301 1 Multinucleate Multinucleate NNP cord-009571-mygj2nd4 301 2 cells cell NNS cord-009571-mygj2nd4 301 3 in in IN cord-009571-mygj2nd4 301 4 rheumatoid rheumatoid NN cord-009571-mygj2nd4 301 5 synovium synovium NN cord-009571-mygj2nd4 301 6 may may MD cord-009571-mygj2nd4 301 7 amplify amplify VB cord-009571-mygj2nd4 301 8 mechanisms mechanism NNS cord-009571-mygj2nd4 301 9 for for IN cord-009571-mygj2nd4 301 10 active active JJ cord-009571-mygj2nd4 301 11 collagenolysis collagenolysis NN cord-009571-mygj2nd4 301 12 . . . cord-009571-mygj2nd4 302 1 Fourteen fourteen CD cord-009571-mygj2nd4 302 2 previously previously RB cord-009571-mygj2nd4 302 3 untreated untreated JJ cord-009571-mygj2nd4 302 4 polymyositis polymyositis NN cord-009571-mygj2nd4 302 5 ( ( -LRB- cord-009571-mygj2nd4 302 6 PM pm NN cord-009571-mygj2nd4 302 7 ) ) -RRB- cord-009571-mygj2nd4 302 8 patients patient NNS cord-009571-mygj2nd4 302 9 were be VBD cord-009571-mygj2nd4 302 10 treated treat VBN cord-009571-mygj2nd4 302 11 with with IN cord-009571-mygj2nd4 302 12 prednisone prednisone NNP cord-009571-mygj2nd4 302 13 60 60 CD cord-009571-mygj2nd4 302 14 mg mg NNP cord-009571-mygj2nd4 302 15 / / SYM cord-009571-mygj2nd4 302 16 day day NN cord-009571-mygj2nd4 302 17 until until IN cord-009571-mygj2nd4 302 18 CPK CPK NNP cord-009571-mygj2nd4 302 19 values value NNS cord-009571-mygj2nd4 302 20 normalized normalize VBN cord-009571-mygj2nd4 302 21 and and CC cord-009571-mygj2nd4 302 22 then then RB cord-009571-mygj2nd4 302 23 with with IN cord-009571-mygj2nd4 302 24 40 40 CD cord-009571-mygj2nd4 302 25 mg mg NNP cord-009571-mygj2nd4 302 26 / / SYM cord-009571-mygj2nd4 302 27 day day NN cord-009571-mygj2nd4 302 28 for for IN cord-009571-mygj2nd4 302 29 a a DT cord-009571-mygj2nd4 302 30 total total NN cord-009571-mygj2nd4 302 31 of of IN cord-009571-mygj2nd4 302 32 12 12 CD cord-009571-mygj2nd4 302 33 weeks week NNS cord-009571-mygj2nd4 302 34 . . . cord-009571-mygj2nd4 303 1 They -PRON- PRP cord-009571-mygj2nd4 303 2 were be VBD cord-009571-mygj2nd4 303 3 also also RB cord-009571-mygj2nd4 303 4 randomly randomly RB cord-009571-mygj2nd4 303 5 placed place VBN cord-009571-mygj2nd4 303 6 on on IN cord-009571-mygj2nd4 303 7 either either CC cord-009571-mygj2nd4 303 8 azathioprine azathioprine NN cord-009571-mygj2nd4 303 9 ( ( -LRB- cord-009571-mygj2nd4 303 10 A a NN cord-009571-mygj2nd4 303 11 ) ) -RRB- cord-009571-mygj2nd4 303 12 2 2 CD cord-009571-mygj2nd4 303 13 mg mg NNP cord-009571-mygj2nd4 303 14 / / SYM cord-009571-mygj2nd4 303 15 kg kg NNP cord-009571-mygj2nd4 303 16 / / SYM cord-009571-mygj2nd4 303 17 day day NN cord-009571-mygj2nd4 303 18 or or CC cord-009571-mygj2nd4 303 19 placebo placebo NN cord-009571-mygj2nd4 303 20 ( ( -LRB- cord-009571-mygj2nd4 303 21 P p NN cord-009571-mygj2nd4 303 22 ) ) -RRB- cord-009571-mygj2nd4 303 23 in in IN cord-009571-mygj2nd4 303 24 double double JJ cord-009571-mygj2nd4 303 25 - - HYPH cord-009571-mygj2nd4 303 26 blinded blinded JJ cord-009571-mygj2nd4 303 27 manner manner NN cord-009571-mygj2nd4 303 28 . . . cord-009571-mygj2nd4 304 1 Manual manual JJ cord-009571-mygj2nd4 304 2 muscle muscle NN cord-009571-mygj2nd4 304 3 testing testing NN cord-009571-mygj2nd4 304 4 , , , cord-009571-mygj2nd4 304 5 total total JJ cord-009571-mygj2nd4 304 6 prednisone prednisone JJ cord-009571-mygj2nd4 304 7 dose dose NN cord-009571-mygj2nd4 304 8 required require VBN cord-009571-mygj2nd4 304 9 over over IN cord-009571-mygj2nd4 304 10 12 12 CD cord-009571-mygj2nd4 304 11 weeks week NNS cord-009571-mygj2nd4 304 12 , , , cord-009571-mygj2nd4 304 13 and and CC cord-009571-mygj2nd4 304 14 muscle muscle NN cord-009571-mygj2nd4 304 15 biopsy biopsy NN cord-009571-mygj2nd4 304 16 changes change NNS cord-009571-mygj2nd4 304 17 were be VBD cord-009571-mygj2nd4 304 18 used use VBN cord-009571-mygj2nd4 304 19 to to TO cord-009571-mygj2nd4 304 20 detect detect VB cord-009571-mygj2nd4 304 21 differences difference NNS cord-009571-mygj2nd4 304 22 in in IN cord-009571-mygj2nd4 304 23 the the DT cord-009571-mygj2nd4 304 24 two two CD cord-009571-mygj2nd4 304 25 groups group NNS cord-009571-mygj2nd4 304 26 . . . cord-009571-mygj2nd4 305 1 The the DT cord-009571-mygj2nd4 305 2 A A NNP cord-009571-mygj2nd4 305 3 group group NN cord-009571-mygj2nd4 305 4 ( ( -LRB- cord-009571-mygj2nd4 305 5 7 7 CD cord-009571-mygj2nd4 305 6 patients patient NNS cord-009571-mygj2nd4 305 7 ) ) -RRB- cord-009571-mygj2nd4 305 8 turned turn VBD cord-009571-mygj2nd4 305 9 out out RP cord-009571-mygj2nd4 305 10 to to TO cord-009571-mygj2nd4 305 11 be be VB cord-009571-mygj2nd4 305 12 weaker weak JJR cord-009571-mygj2nd4 305 13 at at IN cord-009571-mygj2nd4 305 14 onset onset NN cord-009571-mygj2nd4 305 15 ( ( -LRB- cord-009571-mygj2nd4 305 16 total total JJ cord-009571-mygj2nd4 305 17 manual manual JJ cord-009571-mygj2nd4 305 18 muscle muscle NN cord-009571-mygj2nd4 305 19 testing testing NN cord-009571-mygj2nd4 305 20 score score NN cord-009571-mygj2nd4 305 21 -280 -280 NN cord-009571-mygj2nd4 305 22 ) ) -RRB- cord-009571-mygj2nd4 305 23 than than IN cord-009571-mygj2nd4 305 24 the the DT cord-009571-mygj2nd4 305 25 P p NN cord-009571-mygj2nd4 305 26 group group NN cord-009571-mygj2nd4 305 27 ( ( -LRB- cord-009571-mygj2nd4 305 28 7 7 CD cord-009571-mygj2nd4 305 29 patients patient NNS cord-009571-mygj2nd4 305 30 with with IN cord-009571-mygj2nd4 305 31 score score NN cord-009571-mygj2nd4 305 32 of of IN cord-009571-mygj2nd4 305 33 -170 -170 NN cord-009571-mygj2nd4 305 34 ) ) -RRB- cord-009571-mygj2nd4 305 35 but but CC cord-009571-mygj2nd4 305 36 improved improve VBD cord-009571-mygj2nd4 305 37 more more RBR cord-009571-mygj2nd4 305 38 ( ( -LRB- cord-009571-mygj2nd4 305 39 44 44 CD cord-009571-mygj2nd4 305 40 points point NNS cord-009571-mygj2nd4 305 41 to to IN cord-009571-mygj2nd4 305 42 -236 -236 VB cord-009571-mygj2nd4 305 43 ) ) -RRB- cord-009571-mygj2nd4 305 44 than than IN cord-009571-mygj2nd4 305 45 the the DT cord-009571-mygj2nd4 305 46 P p NN cord-009571-mygj2nd4 305 47 group group NN cord-009571-mygj2nd4 305 48 ( ( -LRB- cord-009571-mygj2nd4 305 49 6 6 CD cord-009571-mygj2nd4 305 50 points point NNS cord-009571-mygj2nd4 305 51 to to IN cord-009571-mygj2nd4 305 52 -164 -164 NN cord-009571-mygj2nd4 305 53 ) ) -RRB- cord-009571-mygj2nd4 305 54 . . . cord-009571-mygj2nd4 306 1 However however RB cord-009571-mygj2nd4 306 2 , , , cord-009571-mygj2nd4 306 3 the the DT cord-009571-mygj2nd4 306 4 difference difference NN cord-009571-mygj2nd4 306 5 in in IN cord-009571-mygj2nd4 306 6 improvement improvement NN cord-009571-mygj2nd4 306 7 was be VBD cord-009571-mygj2nd4 306 8 not not RB cord-009571-mygj2nd4 306 9 statistically statistically RB cord-009571-mygj2nd4 306 10 significant significant JJ cord-009571-mygj2nd4 306 11 . . . cord-009571-mygj2nd4 307 1 CPKs cpk NNS cord-009571-mygj2nd4 307 2 in in IN cord-009571-mygj2nd4 307 3 the the DT cord-009571-mygj2nd4 307 4 two two CD cord-009571-mygj2nd4 307 5 groups group NNS cord-009571-mygj2nd4 307 6 normalized normalize VBD cord-009571-mygj2nd4 307 7 a a DT cord-009571-mygj2nd4 307 8 t t NN cord-009571-mygj2nd4 307 9 about about IN cord-009571-mygj2nd4 307 10 the the DT cord-009571-mygj2nd4 307 11 same same JJ cord-009571-mygj2nd4 307 12 rate rate NN cord-009571-mygj2nd4 307 13 and and CC cord-009571-mygj2nd4 307 14 each each DT cord-009571-mygj2nd4 307 15 group group NN cord-009571-mygj2nd4 307 16 therefore therefore RB cord-009571-mygj2nd4 307 17 received receive VBD cord-009571-mygj2nd4 307 18 comparable comparable JJ cord-009571-mygj2nd4 307 19 doses dose NNS cord-009571-mygj2nd4 307 20 of of IN cord-009571-mygj2nd4 307 21 prednisone prednisone NN cord-009571-mygj2nd4 307 22 over over IN cord-009571-mygj2nd4 307 23 the the DT cord-009571-mygj2nd4 307 24 12 12 CD cord-009571-mygj2nd4 307 25 weeks week NNS cord-009571-mygj2nd4 307 26 . . . cord-009571-mygj2nd4 308 1 All all DT cord-009571-mygj2nd4 308 2 followup followup JJ cord-009571-mygj2nd4 308 3 muscle muscle NN cord-009571-mygj2nd4 308 4 biopsies biopsy NNS cord-009571-mygj2nd4 308 5 at at IN cord-009571-mygj2nd4 308 6 the the DT cord-009571-mygj2nd4 308 7 end end NN cord-009571-mygj2nd4 308 8 of of IN cord-009571-mygj2nd4 308 9 12 12 CD cord-009571-mygj2nd4 308 10 weeks week NNS cord-009571-mygj2nd4 308 11 showed show VBD cord-009571-mygj2nd4 308 12 improvement improvement NN cord-009571-mygj2nd4 308 13 in in IN cord-009571-mygj2nd4 308 14 the the DT cord-009571-mygj2nd4 308 15 majority majority NN cord-009571-mygj2nd4 308 16 of of IN cord-009571-mygj2nd4 308 17 the the DT cord-009571-mygj2nd4 308 18 eight eight CD cord-009571-mygj2nd4 308 19 microscopic microscopic JJ cord-009571-mygj2nd4 308 20 features feature NNS cord-009571-mygj2nd4 308 21 reviewed review VBN cord-009571-mygj2nd4 308 22 and and CC cord-009571-mygj2nd4 308 23 in in IN cord-009571-mygj2nd4 308 24 total total JJ cord-009571-mygj2nd4 308 25 numerical numerical JJ cord-009571-mygj2nd4 308 26 score score NN cord-009571-mygj2nd4 308 27 . . . cord-009571-mygj2nd4 309 1 The the DT cord-009571-mygj2nd4 309 2 trend trend NN cord-009571-mygj2nd4 309 3 was be VBD cord-009571-mygj2nd4 309 4 toward toward IN cord-009571-mygj2nd4 309 5 greater great JJR cord-009571-mygj2nd4 309 6 improvement improvement NN cord-009571-mygj2nd4 309 7 in in IN cord-009571-mygj2nd4 309 8 the the DT cord-009571-mygj2nd4 309 9 A A NNP cord-009571-mygj2nd4 309 10 group group NN cord-009571-mygj2nd4 309 11 but but CC cord-009571-mygj2nd4 309 12 not not RB cord-009571-mygj2nd4 309 13 significantly significantly RB cord-009571-mygj2nd4 309 14 so so RB cord-009571-mygj2nd4 309 15 . . . cord-009571-mygj2nd4 310 1 Changes change NNS cord-009571-mygj2nd4 310 2 consistent consistent JJ cord-009571-mygj2nd4 310 3 with with IN cord-009571-mygj2nd4 310 4 steroid steroid NN cord-009571-mygj2nd4 310 5 myopathy myopathy NNS cord-009571-mygj2nd4 310 6 were be VBD cord-009571-mygj2nd4 310 7 noted note VBN cord-009571-mygj2nd4 310 8 in in IN cord-009571-mygj2nd4 310 9 7 7 CD cord-009571-mygj2nd4 310 10 of of IN cord-009571-mygj2nd4 310 11 9 9 CD cord-009571-mygj2nd4 310 12 women woman NNS cord-009571-mygj2nd4 310 13 but but CC cord-009571-mygj2nd4 310 14 only only RB cord-009571-mygj2nd4 310 15 1 1 CD cord-009571-mygj2nd4 310 16 of of IN cord-009571-mygj2nd4 310 17 5 5 CD cord-009571-mygj2nd4 310 18 men man NNS cord-009571-mygj2nd4 310 19 ( ( -LRB- cord-009571-mygj2nd4 310 20 4 4 CD cord-009571-mygj2nd4 310 21 in in IN cord-009571-mygj2nd4 310 22 A a NN cord-009571-mygj2nd4 310 23 and and CC cord-009571-mygj2nd4 310 24 4 4 CD cord-009571-mygj2nd4 310 25 in in IN cord-009571-mygj2nd4 310 26 P p NN cord-009571-mygj2nd4 310 27 ) ) -RRB- cord-009571-mygj2nd4 310 28 and and CC cord-009571-mygj2nd4 310 29 5 5 CD cord-009571-mygj2nd4 310 30 of of IN cord-009571-mygj2nd4 310 31 these these DT cord-009571-mygj2nd4 310 32 8 8 CD cord-009571-mygj2nd4 310 33 patients patient NNS cord-009571-mygj2nd4 310 34 were be VBD cord-009571-mygj2nd4 310 35 weaker weak JJR cord-009571-mygj2nd4 310 36 at at IN cord-009571-mygj2nd4 310 37 12 12 CD cord-009571-mygj2nd4 310 38 weeks week NNS cord-009571-mygj2nd4 310 39 . . . cord-009571-mygj2nd4 311 1 Of of IN cord-009571-mygj2nd4 311 2 special special JJ cord-009571-mygj2nd4 311 3 note note NN cord-009571-mygj2nd4 311 4 is be VBZ cord-009571-mygj2nd4 311 5 the the DT cord-009571-mygj2nd4 311 6 observation observation NN cord-009571-mygj2nd4 311 7 that that IN cord-009571-mygj2nd4 311 8 of of IN cord-009571-mygj2nd4 311 9 13 13 CD cord-009571-mygj2nd4 311 10 patients patient NNS cord-009571-mygj2nd4 311 11 with with IN cord-009571-mygj2nd4 311 12 normal normal JJ cord-009571-mygj2nd4 311 13 CPK CPK NNP cord-009571-mygj2nd4 311 14 at at IN cord-009571-mygj2nd4 311 15 I2 I2 NNP cord-009571-mygj2nd4 311 16 weeks week NNS cord-009571-mygj2nd4 311 17 , , , cord-009571-mygj2nd4 311 18 8 8 CD cord-009571-mygj2nd4 311 19 still still RB cord-009571-mygj2nd4 311 20 had have VBD cord-009571-mygj2nd4 311 21 significant significant JJ cord-009571-mygj2nd4 311 22 inflammatory inflammatory JJ cord-009571-mygj2nd4 311 23 infiltrates infiltrate NNS cord-009571-mygj2nd4 311 24 . . . cord-009571-mygj2nd4 312 1 Therefore therefore RB cord-009571-mygj2nd4 312 2 , , , cord-009571-mygj2nd4 312 3 azathioprine azathioprine JJ cord-009571-mygj2nd4 312 4 plus plus CC cord-009571-mygj2nd4 312 5 prednisone prednisone NN cord-009571-mygj2nd4 312 6 is be VBZ cord-009571-mygj2nd4 312 7 not not RB cord-009571-mygj2nd4 312 8 dramatically dramatically RB cord-009571-mygj2nd4 312 9 better well JJR cord-009571-mygj2nd4 312 10 than than IN cord-009571-mygj2nd4 312 11 prednisone prednisone NNP cord-009571-mygj2nd4 312 12 alone alone RB cord-009571-mygj2nd4 312 13 in in IN cord-009571-mygj2nd4 312 14 polymyositis polymyositis NNP cord-009571-mygj2nd4 312 15 over over IN cord-009571-mygj2nd4 312 16 the the DT cord-009571-mygj2nd4 312 17 initial initial JJ cord-009571-mygj2nd4 312 18 12 12 CD cord-009571-mygj2nd4 312 19 weeks week NNS cord-009571-mygj2nd4 312 20 of of IN cord-009571-mygj2nd4 312 21 treatment treatment NN cord-009571-mygj2nd4 312 22 . . . cord-009571-mygj2nd4 313 1 The the DT cord-009571-mygj2nd4 313 2 development development NN cord-009571-mygj2nd4 313 3 of of IN cord-009571-mygj2nd4 313 4 steroid steroid NN cord-009571-mygj2nd4 313 5 myopathy myopathy NN cord-009571-mygj2nd4 313 6 in in IN cord-009571-mygj2nd4 313 7 over over IN cord-009571-mygj2nd4 313 8 one one CD cord-009571-mygj2nd4 313 9 half half NN cord-009571-mygj2nd4 313 10 the the DT cord-009571-mygj2nd4 313 11 patients patient NNS cord-009571-mygj2nd4 313 12 is be VBZ cord-009571-mygj2nd4 313 13 not not RB cord-009571-mygj2nd4 313 14 influenced influence VBN cord-009571-mygj2nd4 313 15 by by IN cord-009571-mygj2nd4 313 16 A A NNP cord-009571-mygj2nd4 313 17 or or CC cord-009571-mygj2nd4 313 18 P p NN cord-009571-mygj2nd4 313 19 and and CC cord-009571-mygj2nd4 313 20 at at IN cord-009571-mygj2nd4 313 21 the the DT cord-009571-mygj2nd4 313 22 prednisone prednisone NNP cord-009571-mygj2nd4 313 23 dosages dosage NNS cord-009571-mygj2nd4 313 24 used use VBN cord-009571-mygj2nd4 313 25 complicates complicate VBZ cord-009571-mygj2nd4 313 26 the the DT cord-009571-mygj2nd4 313 27 evaluation evaluation NN cord-009571-mygj2nd4 313 28 of of IN cord-009571-mygj2nd4 313 29 changes change NNS cord-009571-mygj2nd4 313 30 in in IN cord-009571-mygj2nd4 313 31 muscle muscle NN cord-009571-mygj2nd4 313 32 strength strength NN cord-009571-mygj2nd4 313 33 ; ; : cord-009571-mygj2nd4 313 34 nevertheless nevertheless RB cord-009571-mygj2nd4 313 35 , , , cord-009571-mygj2nd4 313 36 the the DT cord-009571-mygj2nd4 313 37 trend trend NN cord-009571-mygj2nd4 313 38 is be VBZ cord-009571-mygj2nd4 313 39 toward toward IN cord-009571-mygj2nd4 313 40 greater great JJR cord-009571-mygj2nd4 313 41 improvement improvement NN cord-009571-mygj2nd4 313 42 in in IN cord-009571-mygj2nd4 313 43 the the DT cord-009571-mygj2nd4 313 44 azathioprine azathioprine JJ cord-009571-mygj2nd4 313 45 group group NN cord-009571-mygj2nd4 313 46 in in IN cord-009571-mygj2nd4 313 47 muscle muscle NN cord-009571-mygj2nd4 313 48 strength strength NN cord-009571-mygj2nd4 313 49 and and CC cord-009571-mygj2nd4 313 50 also also RB cord-009571-mygj2nd4 313 51 follow follow VB cord-009571-mygj2nd4 313 52 - - HYPH cord-009571-mygj2nd4 313 53 up up RP cord-009571-mygj2nd4 313 54 muscle muscle NN cord-009571-mygj2nd4 313 55 biopsy biopsy NN cord-009571-mygj2nd4 313 56 scores score NNS cord-009571-mygj2nd4 313 57 . . . cord-009571-mygj2nd4 314 1 Surprisingly surprisingly RB cord-009571-mygj2nd4 314 2 , , , cord-009571-mygj2nd4 314 3 a a DT cord-009571-mygj2nd4 314 4 normal normal JJ cord-009571-mygj2nd4 314 5 CPK CPK NNP cord-009571-mygj2nd4 314 6 does do VBZ cord-009571-mygj2nd4 314 7 not not RB cord-009571-mygj2nd4 314 8 indicate indicate VB cord-009571-mygj2nd4 314 9 resolution resolution NN cord-009571-mygj2nd4 314 10 of of IN cord-009571-mygj2nd4 314 11 inflammation inflammation NN cord-009571-mygj2nd4 314 12 in in IN cord-009571-mygj2nd4 314 13 the the DT cord-009571-mygj2nd4 314 14 muscle muscle NN cord-009571-mygj2nd4 314 15 and and CC cord-009571-mygj2nd4 314 16 can can MD cord-009571-mygj2nd4 314 17 not not RB cord-009571-mygj2nd4 314 18 be be VB cord-009571-mygj2nd4 314 19 used use VBN cord-009571-mygj2nd4 314 20 reliably reliably RB cord-009571-mygj2nd4 314 21 to to TO cord-009571-mygj2nd4 314 22 indicate indicate VB cord-009571-mygj2nd4 314 23 full full JJ cord-009571-mygj2nd4 314 24 control control NN cord-009571-mygj2nd4 314 25 of of IN cord-009571-mygj2nd4 314 26 the the DT cord-009571-mygj2nd4 314 27 disease disease NN cord-009571-mygj2nd4 314 28 . . . cord-009571-mygj2nd4 315 1 Followup Followup NNP cord-009571-mygj2nd4 315 2 is be VBZ cord-009571-mygj2nd4 315 3 continuing continue VBG cord-009571-mygj2nd4 315 4 . . . cord-009571-mygj2nd4 316 1 With with IN cord-009571-mygj2nd4 316 2 the the DT cord-009571-mygj2nd4 316 3 appreciation appreciation NN cord-009571-mygj2nd4 316 4 of of IN cord-009571-mygj2nd4 316 5 the the DT cord-009571-mygj2nd4 316 6 relationship relationship NN cord-009571-mygj2nd4 316 7 between between IN cord-009571-mygj2nd4 316 8 immunogenetics immunogenetic NNS cord-009571-mygj2nd4 316 9 and and CC cord-009571-mygj2nd4 316 10 infection infection NN cord-009571-mygj2nd4 316 11 in in IN cord-009571-mygj2nd4 316 12 the the DT cord-009571-mygj2nd4 316 13 pathogenesis pathogenesis NN cord-009571-mygj2nd4 316 14 of of IN cord-009571-mygj2nd4 316 15 RS rs NN cord-009571-mygj2nd4 316 16 , , , cord-009571-mygj2nd4 316 17 interest interest NN cord-009571-mygj2nd4 316 18 in in IN cord-009571-mygj2nd4 316 19 this this DT cord-009571-mygj2nd4 316 20 condition condition NN cord-009571-mygj2nd4 316 21 is be VBZ cord-009571-mygj2nd4 316 22 increasing increase VBG cord-009571-mygj2nd4 316 23 . . . cord-009571-mygj2nd4 317 1 In in IN cord-009571-mygj2nd4 317 2 order order NN cord-009571-mygj2nd4 317 3 to to TO cord-009571-mygj2nd4 317 4 determine determine VB cord-009571-mygj2nd4 317 5 more more RBR cord-009571-mygj2nd4 317 6 precisely precisely RB cord-009571-mygj2nd4 317 7 the the DT cord-009571-mygj2nd4 317 8 natural natural JJ cord-009571-mygj2nd4 317 9 history history NN cord-009571-mygj2nd4 317 10 of of IN cord-009571-mygj2nd4 317 11 RS rs NN cord-009571-mygj2nd4 317 12 , , , cord-009571-mygj2nd4 317 13 data datum NNS cord-009571-mygj2nd4 317 14 are be VBP cord-009571-mygj2nd4 317 15 presented present VBN cord-009571-mygj2nd4 317 16 from from IN cord-009571-mygj2nd4 317 17 two two CD cord-009571-mygj2nd4 317 18 distinct distinct JJ cord-009571-mygj2nd4 317 19 California California NNP cord-009571-mygj2nd4 317 20 communities community NNS cord-009571-mygj2nd4 317 21 : : : cord-009571-mygj2nd4 317 22 University University NNP cord-009571-mygj2nd4 317 23 ( ( -LRB- cord-009571-mygj2nd4 317 24 PA PA NNP cord-009571-mygj2nd4 317 25 ) ) -RRB- cord-009571-mygj2nd4 317 26 and and CC cord-009571-mygj2nd4 317 27 Community Community NNP cord-009571-mygj2nd4 317 28 ( ( -LRB- cord-009571-mygj2nd4 317 29 SB SB NNP cord-009571-mygj2nd4 317 30 ) ) -RRB- cord-009571-mygj2nd4 317 31 . . . cord-009571-mygj2nd4 318 1 To to IN cord-009571-mygj2nd4 318 2 date date NN cord-009571-mygj2nd4 318 3 , , , cord-009571-mygj2nd4 318 4 102 102 CD cord-009571-mygj2nd4 318 5 consecutive consecutive JJ cord-009571-mygj2nd4 318 6 patients patient NNS cord-009571-mygj2nd4 318 7 have have VBP cord-009571-mygj2nd4 318 8 been be VBN cord-009571-mygj2nd4 318 9 studied study VBN cord-009571-mygj2nd4 318 10 : : : cord-009571-mygj2nd4 318 11 77 77 CD cord-009571-mygj2nd4 318 12 ( ( -LRB- cord-009571-mygj2nd4 318 13 PA PA NNP cord-009571-mygj2nd4 318 14 ) ) -RRB- cord-009571-mygj2nd4 318 15 and and CC cord-009571-mygj2nd4 318 16 25 25 CD cord-009571-mygj2nd4 318 17 ( ( -LRB- cord-009571-mygj2nd4 318 18 SB SB NNP cord-009571-mygj2nd4 318 19 ) ) -RRB- cord-009571-mygj2nd4 318 20 . . . cord-009571-mygj2nd4 319 1 RS RS NNP cord-009571-mygj2nd4 319 2 is be VBZ cord-009571-mygj2nd4 319 3 defined define VBN cord-009571-mygj2nd4 319 4 as as IN cord-009571-mygj2nd4 319 5 an an DT cord-009571-mygj2nd4 319 6 asymmetric asymmetric JJ cord-009571-mygj2nd4 319 7 oligoarthropathy oligoarthropathy NN cord-009571-mygj2nd4 319 8 ( ( -LRB- cord-009571-mygj2nd4 319 9 predominantly predominantly RB cord-009571-mygj2nd4 319 10 lower low JJR cord-009571-mygj2nd4 319 11 extremity extremity NN cord-009571-mygj2nd4 319 12 ) ) -RRB- cord-009571-mygj2nd4 319 13 accom accom NN cord-009571-mygj2nd4 319 14 - - HYPH cord-009571-mygj2nd4 319 15 panied panie VBN cord-009571-mygj2nd4 319 16 by by IN cord-009571-mygj2nd4 319 17 one one CD cord-009571-mygj2nd4 319 18 or or CC cord-009571-mygj2nd4 319 19 more more JJR cord-009571-mygj2nd4 319 20 of of IN cord-009571-mygj2nd4 319 21 the the DT cord-009571-mygj2nd4 319 22 following follow VBG cord-009571-mygj2nd4 319 23 symptoms symptom NNS cord-009571-mygj2nd4 319 24 : : : cord-009571-mygj2nd4 319 25 1 1 LS cord-009571-mygj2nd4 319 26 ) ) -RRB- cord-009571-mygj2nd4 319 27 urethritis urethritis NN cord-009571-mygj2nd4 319 28 , , , cord-009571-mygj2nd4 319 29 2 2 CD cord-009571-mygj2nd4 319 30 ) ) -RRB- cord-009571-mygj2nd4 319 31 diarrhea diarrhea NN cord-009571-mygj2nd4 319 32 at at IN cord-009571-mygj2nd4 319 33 onset onset NN cord-009571-mygj2nd4 319 34 , , , cord-009571-mygj2nd4 319 35 3 3 CD cord-009571-mygj2nd4 319 36 ) ) -RRB- cord-009571-mygj2nd4 320 1 inflammatory inflammatory JJ cord-009571-mygj2nd4 320 2 eye eye NN cord-009571-mygj2nd4 320 3 disease disease NN cord-009571-mygj2nd4 320 4 , , , cord-009571-mygj2nd4 320 5 4 4 CD cord-009571-mygj2nd4 320 6 ) ) -RRB- cord-009571-mygj2nd4 320 7 mucocutaneous mucocutaneous JJ cord-009571-mygj2nd4 320 8 manifestations manifestation NNS cord-009571-mygj2nd4 320 9 consisting consist VBG cord-009571-mygj2nd4 320 10 of of IN cord-009571-mygj2nd4 320 11 balanitis balanitis NN cord-009571-mygj2nd4 320 12 , , , cord-009571-mygj2nd4 320 13 buccal buccal JJ cord-009571-mygj2nd4 320 14 ulceration ulceration NN cord-009571-mygj2nd4 320 15 , , , cord-009571-mygj2nd4 320 16 or or CC cord-009571-mygj2nd4 320 17 keratodermia keratodermia NNP cord-009571-mygj2nd4 320 18 blennorrhagica blennorrhagica NNP cord-009571-mygj2nd4 320 19 . . . cord-009571-mygj2nd4 321 1 Patients patient NNS cord-009571-mygj2nd4 321 2 with with IN cord-009571-mygj2nd4 321 3 ankylosing ankylose VBG cord-009571-mygj2nd4 321 4 spondylitis spondylitis NN cord-009571-mygj2nd4 321 5 , , , cord-009571-mygj2nd4 321 6 psoriatic psoriatic JJ cord-009571-mygj2nd4 321 7 arthropathy arthropathy NNP cord-009571-mygj2nd4 321 8 , , , cord-009571-mygj2nd4 321 9 or or CC cord-009571-mygj2nd4 321 10 other other JJ cord-009571-mygj2nd4 321 11 rheumatic rheumatic JJ cord-009571-mygj2nd4 321 12 syndromes syndrome NNS cord-009571-mygj2nd4 321 13 were be VBD cord-009571-mygj2nd4 321 14 excluded exclude VBN cord-009571-mygj2nd4 321 15 . . . cord-009571-mygj2nd4 322 1 Nineteen nineteen CD cord-009571-mygj2nd4 322 2 ( ( -LRB- cord-009571-mygj2nd4 322 3 19 19 CD cord-009571-mygj2nd4 322 4 % % NN cord-009571-mygj2nd4 322 5 ) ) -RRB- cord-009571-mygj2nd4 322 6 of of IN cord-009571-mygj2nd4 322 7 the the DT cord-009571-mygj2nd4 322 8 102 102 CD cord-009571-mygj2nd4 322 9 presented present VBN cord-009571-mygj2nd4 322 10 with with IN cord-009571-mygj2nd4 322 11 diarrhea diarrhea NN cord-009571-mygj2nd4 322 12 and and CC cord-009571-mygj2nd4 322 13 74 74 CD cord-009571-mygj2nd4 322 14 ( ( -LRB- cord-009571-mygj2nd4 322 15 73 73 CD cord-009571-mygj2nd4 322 16 % % NN cord-009571-mygj2nd4 322 17 ) ) -RRB- cord-009571-mygj2nd4 322 18 had have VBD cord-009571-mygj2nd4 322 19 at at IN cord-009571-mygj2nd4 322 20 least least JJS cord-009571-mygj2nd4 322 21 a a DT cord-009571-mygj2nd4 322 22 triad triad NN cord-009571-mygj2nd4 322 23 of of IN cord-009571-mygj2nd4 322 24 the the DT cord-009571-mygj2nd4 322 25 above above JJ cord-009571-mygj2nd4 322 26 features feature NNS cord-009571-mygj2nd4 322 27 . . . cord-009571-mygj2nd4 323 1 There there EX cord-009571-mygj2nd4 323 2 were be VBD cord-009571-mygj2nd4 323 3 more more JJR cord-009571-mygj2nd4 323 4 similarities similarity NNS cord-009571-mygj2nd4 323 5 than than IN cord-009571-mygj2nd4 323 6 differences difference NNS cord-009571-mygj2nd4 323 7 between between IN cord-009571-mygj2nd4 323 8 SB SB NNP cord-009571-mygj2nd4 323 9 and and CC cord-009571-mygj2nd4 323 10 PA PA NNP cord-009571-mygj2nd4 323 11 . . . cord-009571-mygj2nd4 324 1 For for IN cord-009571-mygj2nd4 324 2 example example NN cord-009571-mygj2nd4 324 3 , , , cord-009571-mygj2nd4 324 4 females female NNS cord-009571-mygj2nd4 324 5 represented represent VBD cord-009571-mygj2nd4 324 6 14 14 CD cord-009571-mygj2nd4 324 7 % % NN cord-009571-mygj2nd4 324 8 ( ( -LRB- cord-009571-mygj2nd4 324 9 SB SB NNP cord-009571-mygj2nd4 324 10 ) ) -RRB- cord-009571-mygj2nd4 324 11 and and CC cord-009571-mygj2nd4 324 12 12 12 CD cord-009571-mygj2nd4 324 13 % % NN cord-009571-mygj2nd4 324 14 ( ( -LRB- cord-009571-mygj2nd4 324 15 PA PA NNP cord-009571-mygj2nd4 324 16 ) ) -RRB- cord-009571-mygj2nd4 324 17 . . . cord-009571-mygj2nd4 325 1 The the DT cord-009571-mygj2nd4 325 2 mean mean JJ cord-009571-mygj2nd4 325 3 duration duration NN cord-009571-mygj2nd4 325 4 of of IN cord-009571-mygj2nd4 325 5 disease disease NN cord-009571-mygj2nd4 325 6 to to IN cord-009571-mygj2nd4 325 7 date date NN cord-009571-mygj2nd4 325 8 is be VBZ cord-009571-mygj2nd4 325 9 76.3 76.3 CD cord-009571-mygj2nd4 325 10 months month NNS cord-009571-mygj2nd4 325 11 ( ( -LRB- cord-009571-mygj2nd4 325 12 SB SB NNP cord-009571-mygj2nd4 325 13 ) ) -RRB- cord-009571-mygj2nd4 325 14 and and CC cord-009571-mygj2nd4 325 15 82.8 82.8 CD cord-009571-mygj2nd4 325 16 months month NNS cord-009571-mygj2nd4 325 17 ( ( -LRB- cord-009571-mygj2nd4 325 18 PA PA NNP cord-009571-mygj2nd4 325 19 ) ) -RRB- cord-009571-mygj2nd4 325 20 , , , cord-009571-mygj2nd4 325 21 disease disease NN cord-009571-mygj2nd4 325 22 activity activity NN cord-009571-mygj2nd4 325 23 continuing continue VBG cord-009571-mygj2nd4 325 24 ( ( -LRB- cord-009571-mygj2nd4 325 25 albeit albeit IN cord-009571-mygj2nd4 325 26 , , , cord-009571-mygj2nd4 325 27 sometimes sometimes RB cord-009571-mygj2nd4 325 28 , , , cord-009571-mygj2nd4 325 29 episodically episodically RB cord-009571-mygj2nd4 325 30 ) ) -RRB- cord-009571-mygj2nd4 325 31 in in IN cord-009571-mygj2nd4 325 32 82 82 CD cord-009571-mygj2nd4 325 33 % % NN cord-009571-mygj2nd4 325 34 of of IN cord-009571-mygj2nd4 325 35 the the DT cord-009571-mygj2nd4 325 36 SB SB NNP cord-009571-mygj2nd4 325 37 practice practice NN cord-009571-mygj2nd4 325 38 and and CC cord-009571-mygj2nd4 325 39 90 90 CD cord-009571-mygj2nd4 325 40 % % NN cord-009571-mygj2nd4 325 41 of of IN cord-009571-mygj2nd4 325 42 the the DT cord-009571-mygj2nd4 325 43 PA PA NNP cord-009571-mygj2nd4 325 44 patients patient NNS cord-009571-mygj2nd4 325 45 . . . cord-009571-mygj2nd4 326 1 HLA HLA NNP cord-009571-mygj2nd4 326 2 - - HYPH cord-009571-mygj2nd4 326 3 B27 B27 NNP cord-009571-mygj2nd4 326 4 was be VBD cord-009571-mygj2nd4 326 5 present present JJ cord-009571-mygj2nd4 326 6 in in IN cord-009571-mygj2nd4 326 7 79 79 CD cord-009571-mygj2nd4 326 8 % % NN cord-009571-mygj2nd4 326 9 ( ( -LRB- cord-009571-mygj2nd4 326 10 SB SB NNP cord-009571-mygj2nd4 326 11 ) ) -RRB- cord-009571-mygj2nd4 326 12 and and CC cord-009571-mygj2nd4 326 13 82 82 CD cord-009571-mygj2nd4 326 14 % % NN cord-009571-mygj2nd4 326 15 ( ( -LRB- cord-009571-mygj2nd4 326 16 PA PA NNP cord-009571-mygj2nd4 326 17 ) ) -RRB- cord-009571-mygj2nd4 326 18 . . . cord-009571-mygj2nd4 327 1 Only only RB cord-009571-mygj2nd4 327 2 7 7 CD cord-009571-mygj2nd4 327 3 % % NN cord-009571-mygj2nd4 327 4 had have VBD cord-009571-mygj2nd4 327 5 a a DT cord-009571-mygj2nd4 327 6 persistent persistent JJ cord-009571-mygj2nd4 327 7 monoarthropathy monoarthropathy NNP cord-009571-mygj2nd4 327 8 . . . cord-009571-mygj2nd4 328 1 Twenty twenty CD cord-009571-mygj2nd4 328 2 - - HYPH cord-009571-mygj2nd4 328 3 four four CD cord-009571-mygj2nd4 328 4 percent percent NN cord-009571-mygj2nd4 328 5 of of IN cord-009571-mygj2nd4 328 6 patients patient NNS cord-009571-mygj2nd4 328 7 had have VBD cord-009571-mygj2nd4 328 8 a a DT cord-009571-mygj2nd4 328 9 positive positive JJ cord-009571-mygj2nd4 328 10 family family NN cord-009571-mygj2nd4 328 11 history history NN cord-009571-mygj2nd4 328 12 for for IN cord-009571-mygj2nd4 328 13 an an DT cord-009571-mygj2nd4 328 14 inflammatory inflammatory JJ cord-009571-mygj2nd4 328 15 polyarthropathy polyarthropathy NN cord-009571-mygj2nd4 328 16 . . . cord-009571-mygj2nd4 329 1 Other other JJ cord-009571-mygj2nd4 329 2 similarities similarity NNS cord-009571-mygj2nd4 329 3 included include VBD cord-009571-mygj2nd4 329 4 keratodermia keratodermia NNP cord-009571-mygj2nd4 329 5 blennorrhagica blennorrhagica NNP cord-009571-mygj2nd4 329 6 in in IN cord-009571-mygj2nd4 329 7 24 24 CD cord-009571-mygj2nd4 329 8 % % NN cord-009571-mygj2nd4 329 9 ( ( -LRB- cord-009571-mygj2nd4 329 10 SB SB NNP cord-009571-mygj2nd4 329 11 ) ) -RRB- cord-009571-mygj2nd4 329 12 and and CC cord-009571-mygj2nd4 329 13 25 25 CD cord-009571-mygj2nd4 329 14 % % NN cord-009571-mygj2nd4 329 15 ( ( -LRB- cord-009571-mygj2nd4 329 16 PA PA NNP cord-009571-mygj2nd4 329 17 ) ) -RRB- cord-009571-mygj2nd4 329 18 , , , cord-009571-mygj2nd4 329 19 tendinitis tendinitis NN cord-009571-mygj2nd4 329 20 in in IN cord-009571-mygj2nd4 329 21 43 43 CD cord-009571-mygj2nd4 329 22 % % NN cord-009571-mygj2nd4 329 23 ( ( -LRB- cord-009571-mygj2nd4 329 24 SB SB NNP cord-009571-mygj2nd4 329 25 ) ) -RRB- cord-009571-mygj2nd4 329 26 and and CC cord-009571-mygj2nd4 329 27 38 38 CD cord-009571-mygj2nd4 329 28 % % NN cord-009571-mygj2nd4 329 29 ( ( -LRB- cord-009571-mygj2nd4 329 30 PA PA NNP cord-009571-mygj2nd4 329 31 ) ) -RRB- cord-009571-mygj2nd4 329 32 and and CC cord-009571-mygj2nd4 329 33 heel heel NN cord-009571-mygj2nd4 329 34 disease disease NN cord-009571-mygj2nd4 329 35 in in IN cord-009571-mygj2nd4 329 36 50 50 CD cord-009571-mygj2nd4 329 37 % % NN cord-009571-mygj2nd4 329 38 ( ( -LRB- cord-009571-mygj2nd4 329 39 SB SB NNP cord-009571-mygj2nd4 329 40 ) ) -RRB- cord-009571-mygj2nd4 329 41 and and CC cord-009571-mygj2nd4 329 42 40 40 CD cord-009571-mygj2nd4 329 43 % % NN cord-009571-mygj2nd4 329 44 ( ( -LRB- cord-009571-mygj2nd4 329 45 PA PA NNP cord-009571-mygj2nd4 329 46 ) ) -RRB- cord-009571-mygj2nd4 329 47 . . . cord-009571-mygj2nd4 330 1 Sacroiliitis Sacroiliitis NNP cord-009571-mygj2nd4 330 2 occurred occur VBD cord-009571-mygj2nd4 330 3 in in IN cord-009571-mygj2nd4 330 4 23 23 CD cord-009571-mygj2nd4 330 5 % % NN cord-009571-mygj2nd4 330 6 , , , cord-009571-mygj2nd4 330 7 50 50 CD cord-009571-mygj2nd4 330 8 % % NN cord-009571-mygj2nd4 330 9 of of IN cord-009571-mygj2nd4 330 10 whom whom WP cord-009571-mygj2nd4 330 11 had have VBD cord-009571-mygj2nd4 330 12 asymmetric asymmetric JJ cord-009571-mygj2nd4 330 13 change change NN cord-009571-mygj2nd4 330 14 . . . cord-009571-mygj2nd4 331 1 Only only RB cord-009571-mygj2nd4 331 2 1 1 CD cord-009571-mygj2nd4 331 3 patient patient NN cord-009571-mygj2nd4 331 4 with with IN cord-009571-mygj2nd4 331 5 sacroiliitis sacroiliitis NNP cord-009571-mygj2nd4 331 6 was be VBD cord-009571-mygj2nd4 331 7 HLA HLA NNP cord-009571-mygj2nd4 331 8 - - HYPH cord-009571-mygj2nd4 331 9 B27 B27 NNP cord-009571-mygj2nd4 331 10 negative negative JJ cord-009571-mygj2nd4 331 11 . . . cord-009571-mygj2nd4 332 1 The the DT cord-009571-mygj2nd4 332 2 ESR ESR NNP cord-009571-mygj2nd4 332 3 ( ( -LRB- cord-009571-mygj2nd4 332 4 3 3 CD cord-009571-mygj2nd4 332 5 - - SYM cord-009571-mygj2nd4 332 6 118 118 CD cord-009571-mygj2nd4 332 7 , , , cord-009571-mygj2nd4 332 8 mean mean VB cord-009571-mygj2nd4 332 9 42 42 CD cord-009571-mygj2nd4 332 10 ) ) -RRB- cord-009571-mygj2nd4 332 11 appeared appear VBD cord-009571-mygj2nd4 332 12 unrelated unrelated JJ cord-009571-mygj2nd4 332 13 to to IN cord-009571-mygj2nd4 332 14 disease disease NN cord-009571-mygj2nd4 332 15 activity activity NN cord-009571-mygj2nd4 332 16 . . . cord-009571-mygj2nd4 333 1 Aortitis Aortitis NNP cord-009571-mygj2nd4 333 2 was be VBD cord-009571-mygj2nd4 333 3 present present JJ cord-009571-mygj2nd4 333 4 in in IN cord-009571-mygj2nd4 333 5 only only RB cord-009571-mygj2nd4 333 6 3 3 CD cord-009571-mygj2nd4 333 7 ( ( -LRB- cord-009571-mygj2nd4 333 8 PA PA NNP cord-009571-mygj2nd4 333 9 ) ) -RRB- cord-009571-mygj2nd4 333 10 patients patient NNS cord-009571-mygj2nd4 333 11 . . . cord-009571-mygj2nd4 334 1 Differences difference NNS cord-009571-mygj2nd4 334 2 between between IN cord-009571-mygj2nd4 334 3 PA PA NNP cord-009571-mygj2nd4 334 4 and and CC cord-009571-mygj2nd4 334 5 SB SB NNP cord-009571-mygj2nd4 334 6 patients patient NNS cord-009571-mygj2nd4 334 7 were be VBD cord-009571-mygj2nd4 334 8 minimal minimal JJ cord-009571-mygj2nd4 334 9 ; ; : cord-009571-mygj2nd4 334 10 balanitis balanitis NN cord-009571-mygj2nd4 334 11 and and CC cord-009571-mygj2nd4 334 12 uveitis uveitis NN cord-009571-mygj2nd4 334 13 appearing appear VBG cord-009571-mygj2nd4 334 14 more more RBR cord-009571-mygj2nd4 334 15 frequently frequently RB cord-009571-mygj2nd4 334 16 in in IN cord-009571-mygj2nd4 334 17 the the DT cord-009571-mygj2nd4 334 18 former former JJ cord-009571-mygj2nd4 334 19 group group NN cord-009571-mygj2nd4 334 20 . . . cord-009571-mygj2nd4 335 1 Buccal buccal JJ cord-009571-mygj2nd4 335 2 ulceration ulceration NN cord-009571-mygj2nd4 335 3 was be VBD cord-009571-mygj2nd4 335 4 seen see VBN cord-009571-mygj2nd4 335 5 in in IN cord-009571-mygj2nd4 335 6 23 23 CD cord-009571-mygj2nd4 335 7 % % NN cord-009571-mygj2nd4 335 8 of of IN cord-009571-mygj2nd4 335 9 the the DT cord-009571-mygj2nd4 335 10 PA PA NNP cord-009571-mygj2nd4 335 11 patients patient NNS cord-009571-mygj2nd4 335 12 and and CC cord-009571-mygj2nd4 335 13 12 12 CD cord-009571-mygj2nd4 335 14 % % NN cord-009571-mygj2nd4 335 15 of of IN cord-009571-mygj2nd4 335 16 the the DT cord-009571-mygj2nd4 335 17 SB SB NNP cord-009571-mygj2nd4 335 18 group group NN cord-009571-mygj2nd4 335 19 . . . cord-009571-mygj2nd4 336 1 From from IN cord-009571-mygj2nd4 336 2 this this DT cord-009571-mygj2nd4 336 3 study study NN cord-009571-mygj2nd4 336 4 we -PRON- PRP cord-009571-mygj2nd4 336 5 conclude conclude VBP cord-009571-mygj2nd4 336 6 : : : cord-009571-mygj2nd4 337 1 1 1 LS cord-009571-mygj2nd4 337 2 ) ) -RRB- cord-009571-mygj2nd4 337 3 RS RS NNP cord-009571-mygj2nd4 337 4 is be VBZ cord-009571-mygj2nd4 337 5 a a DT cord-009571-mygj2nd4 337 6 major major JJ cord-009571-mygj2nd4 337 7 chronic chronic JJ cord-009571-mygj2nd4 337 8 rheumatic rheumatic JJ cord-009571-mygj2nd4 337 9 disease disease NN cord-009571-mygj2nd4 337 10 ; ; : cord-009571-mygj2nd4 337 11 at at RB cord-009571-mygj2nd4 337 12 least least JJS cord-009571-mygj2nd4 337 13 two two CD cord-009571-mygj2nd4 337 14 - - HYPH cord-009571-mygj2nd4 337 15 thirds third NNS cord-009571-mygj2nd4 337 16 of of IN cord-009571-mygj2nd4 337 17 patients patient NNS cord-009571-mygj2nd4 337 18 have have VBP cord-009571-mygj2nd4 337 19 active active JJ cord-009571-mygj2nd4 337 20 disease disease NN cord-009571-mygj2nd4 337 21 at at IN cord-009571-mygj2nd4 337 22 an an DT cord-009571-mygj2nd4 337 23 81 81 CD cord-009571-mygj2nd4 337 24 month month NN cord-009571-mygj2nd4 337 25 followup followup NN cord-009571-mygj2nd4 337 26 . . . cord-009571-mygj2nd4 338 1 The the DT cord-009571-mygj2nd4 338 2 prognosis prognosis NN cord-009571-mygj2nd4 338 3 for for IN cord-009571-mygj2nd4 338 4 occupation occupation NN cord-009571-mygj2nd4 338 5 requiring require VBG cord-009571-mygj2nd4 338 6 significant significant JJ cord-009571-mygj2nd4 338 7 exertion exertion NN cord-009571-mygj2nd4 338 8 should should MD cord-009571-mygj2nd4 338 9 remain remain VB cord-009571-mygj2nd4 338 10 guarded guarded JJ cord-009571-mygj2nd4 338 11 . . . cord-009571-mygj2nd4 339 1 2 2 LS cord-009571-mygj2nd4 339 2 ) ) -RRB- cord-009571-mygj2nd4 340 1 There there EX cord-009571-mygj2nd4 340 2 are be VBP cord-009571-mygj2nd4 340 3 minimal minimal JJ cord-009571-mygj2nd4 340 4 differences difference NNS cord-009571-mygj2nd4 340 5 between between IN cord-009571-mygj2nd4 340 6 an an DT cord-009571-mygj2nd4 340 7 academic academic JJ cord-009571-mygj2nd4 340 8 and and CC cord-009571-mygj2nd4 340 9 community community NN cord-009571-mygj2nd4 340 10 population population NN cord-009571-mygj2nd4 340 11 of of IN cord-009571-mygj2nd4 340 12 RS rs NN cord-009571-mygj2nd4 340 13 patients patient NNS cord-009571-mygj2nd4 340 14 . . . cord-009571-mygj2nd4 341 1 3 3 LS cord-009571-mygj2nd4 341 2 ) ) -RRB- cord-009571-mygj2nd4 342 1 There there EX cord-009571-mygj2nd4 342 2 were be VBD cord-009571-mygj2nd4 342 3 no no DT cord-009571-mygj2nd4 342 4 discernible discernible JJ cord-009571-mygj2nd4 342 5 differences difference NNS cord-009571-mygj2nd4 342 6 between between IN cord-009571-mygj2nd4 342 7 disease disease NN cord-009571-mygj2nd4 342 8 severity severity NN cord-009571-mygj2nd4 342 9 in in IN cord-009571-mygj2nd4 342 10 HLA HLA NNP cord-009571-mygj2nd4 342 11 - - HYPH cord-009571-mygj2nd4 342 12 B27 B27 NNP cord-009571-mygj2nd4 342 13 positive positive JJ cord-009571-mygj2nd4 342 14 and and CC cord-009571-mygj2nd4 342 15 negative negative JJ cord-009571-mygj2nd4 342 16 patients patient NNS cord-009571-mygj2nd4 342 17 . . . cord-009571-mygj2nd4 343 1 The the DT cord-009571-mygj2nd4 343 2 activities activity NNS cord-009571-mygj2nd4 343 3 of of IN cord-009571-mygj2nd4 343 4 the the DT cord-009571-mygj2nd4 343 5 major major JJ cord-009571-mygj2nd4 343 6 fragment fragment NN cord-009571-mygj2nd4 343 7 of of IN cord-009571-mygj2nd4 343 8 the the DT cord-009571-mygj2nd4 343 9 third third JJ cord-009571-mygj2nd4 343 10 component component NN cord-009571-mygj2nd4 343 11 of of IN cord-009571-mygj2nd4 343 12 complement complement NN cord-009571-mygj2nd4 343 13 , , , cord-009571-mygj2nd4 343 14 C3b C3b NNP cord-009571-mygj2nd4 343 15 , , , cord-009571-mygj2nd4 343 16 are be VBP cord-009571-mygj2nd4 343 17 controlled control VBN cord-009571-mygj2nd4 343 18 by by IN cord-009571-mygj2nd4 343 19 at at RB cord-009571-mygj2nd4 343 20 least least RBS cord-009571-mygj2nd4 343 21 two two CD cord-009571-mygj2nd4 343 22 proteins protein NNS cord-009571-mygj2nd4 343 23 , , , cord-009571-mygj2nd4 343 24 C3b C3b NNP cord-009571-mygj2nd4 343 25 inactivator inactivator NNP cord-009571-mygj2nd4 343 26 and and CC cord-009571-mygj2nd4 343 27 B1H B1H NNP cord-009571-mygj2nd4 343 28 globulin globulin NN cord-009571-mygj2nd4 343 29 . . . cord-009571-mygj2nd4 344 1 Using use VBG cord-009571-mygj2nd4 344 2 in in IN cord-009571-mygj2nd4 344 3 vitro vitro FW cord-009571-mygj2nd4 344 4 model model NN cord-009571-mygj2nd4 344 5 systems system NNS cord-009571-mygj2nd4 344 6 , , , cord-009571-mygj2nd4 344 7 we -PRON- PRP cord-009571-mygj2nd4 344 8 have have VBP cord-009571-mygj2nd4 344 9 previously previously RB cord-009571-mygj2nd4 344 10 demonstrated demonstrate VBN cord-009571-mygj2nd4 344 11 that that IN cord-009571-mygj2nd4 344 12 81 81 CD cord-009571-mygj2nd4 344 13 H h NN cord-009571-mygj2nd4 344 14 physically physically RB cord-009571-mygj2nd4 344 15 binds bind VBZ cord-009571-mygj2nd4 344 16 to to IN cord-009571-mygj2nd4 344 17 C3b C3b NNP cord-009571-mygj2nd4 344 18 and and CC cord-009571-mygj2nd4 344 19 blocks block VBZ cord-009571-mygj2nd4 344 20 its -PRON- PRP$ cord-009571-mygj2nd4 344 21 activity activity NN cord-009571-mygj2nd4 344 22 . . . cord-009571-mygj2nd4 345 1 In in IN cord-009571-mygj2nd4 345 2 the the DT cord-009571-mygj2nd4 345 3 present present JJ cord-009571-mygj2nd4 345 4 report report NN cord-009571-mygj2nd4 345 5 immunofluorescent immunofluorescent JJ cord-009571-mygj2nd4 345 6 examination examination NN cord-009571-mygj2nd4 345 7 of of IN cord-009571-mygj2nd4 345 8 renal renal JJ cord-009571-mygj2nd4 345 9 biopsies biopsy NNS cord-009571-mygj2nd4 345 10 has have VBZ cord-009571-mygj2nd4 345 11 been be VBN cord-009571-mygj2nd4 345 12 used use VBN cord-009571-mygj2nd4 345 13 to to TO cord-009571-mygj2nd4 345 14 demonstrate demonstrate VB cord-009571-mygj2nd4 345 15 that that IN cord-009571-mygj2nd4 345 16 similar similar JJ cord-009571-mygj2nd4 345 17 C3b c3b NN cord-009571-mygj2nd4 345 18 - - HYPH cord-009571-mygj2nd4 345 19 BlH blh NN cord-009571-mygj2nd4 345 20 interaction interaction NN cord-009571-mygj2nd4 345 21 occurs occur VBZ cord-009571-mygj2nd4 345 22 in in IN cord-009571-mygj2nd4 345 23 vivo vivo NN cord-009571-mygj2nd4 345 24 . . . cord-009571-mygj2nd4 346 1 Twelve twelve CD cord-009571-mygj2nd4 346 2 biopsies biopsy NNS cord-009571-mygj2nd4 346 3 from from IN cord-009571-mygj2nd4 346 4 patients patient NNS cord-009571-mygj2nd4 346 5 with with IN cord-009571-mygj2nd4 346 6 systemic systemic JJ cord-009571-mygj2nd4 346 7 lupus lupus NN cord-009571-mygj2nd4 346 8 erythematosus erythematosus NN cord-009571-mygj2nd4 346 9 or or CC cord-009571-mygj2nd4 346 10 acute acute JJ cord-009571-mygj2nd4 346 11 poststreptococcal poststreptococcal JJ cord-009571-mygj2nd4 346 12 glomerulonephritis glomerulonephritis NN cord-009571-mygj2nd4 346 13 were be VBD cord-009571-mygj2nd4 346 14 examined examine VBN cord-009571-mygj2nd4 346 15 . . . cord-009571-mygj2nd4 347 1 IgG IgG NNP cord-009571-mygj2nd4 347 2 and and CC cord-009571-mygj2nd4 347 3 complement complement VB cord-009571-mygj2nd4 347 4 components component NNS cord-009571-mygj2nd4 347 5 were be VBD cord-009571-mygj2nd4 347 6 found find VBN cord-009571-mygj2nd4 347 7 by by IN cord-009571-mygj2nd4 347 8 immunofluorescence immunofluorescence NN cord-009571-mygj2nd4 347 9 to to TO cord-009571-mygj2nd4 347 10 be be VB cord-009571-mygj2nd4 347 11 deposited deposit VBN cord-009571-mygj2nd4 347 12 in in IN cord-009571-mygj2nd4 347 13 a a DT cord-009571-mygj2nd4 347 14 granular granular JJ cord-009571-mygj2nd4 347 15 fashion fashion NN cord-009571-mygj2nd4 347 16 in in IN cord-009571-mygj2nd4 347 17 the the DT cord-009571-mygj2nd4 347 18 glomeruli glomerulus NNS cord-009571-mygj2nd4 347 19 of of IN cord-009571-mygj2nd4 347 20 these these DT cord-009571-mygj2nd4 347 21 specimens specimen NNS cord-009571-mygj2nd4 347 22 . . . cord-009571-mygj2nd4 348 1 By by IN cord-009571-mygj2nd4 348 2 electron electron NN cord-009571-mygj2nd4 348 3 microscopy microscopy NNS cord-009571-mygj2nd4 348 4 , , , cord-009571-mygj2nd4 348 5 mesangial mesangial JJ cord-009571-mygj2nd4 348 6 , , , cord-009571-mygj2nd4 348 7 subendothelial subendothelial NNP cord-009571-mygj2nd4 348 8 , , , cord-009571-mygj2nd4 348 9 intramembranous intramembranous NNP cord-009571-mygj2nd4 348 10 and/or and/or CC cord-009571-mygj2nd4 348 11 subepithelial subepithelial JJ cord-009571-mygj2nd4 348 12 electron electron NN cord-009571-mygj2nd4 348 13 dense dense JJ cord-009571-mygj2nd4 348 14 deposits deposit NNS cord-009571-mygj2nd4 348 15 were be VBD cord-009571-mygj2nd4 348 16 found find VBN cord-009571-mygj2nd4 348 17 . . . cord-009571-mygj2nd4 349 1 A a DT cord-009571-mygj2nd4 349 2 single single JJ cord-009571-mygj2nd4 349 3 biospy biospy NN cord-009571-mygj2nd4 349 4 in in IN cord-009571-mygj2nd4 349 5 which which WDT cord-009571-mygj2nd4 349 6 only only RB cord-009571-mygj2nd4 349 7 C3 C3 NNP cord-009571-mygj2nd4 349 8 was be VBD cord-009571-mygj2nd4 349 9 found find VBN cord-009571-mygj2nd4 349 10 to to TO cord-009571-mygj2nd4 349 11 be be VB cord-009571-mygj2nd4 349 12 deposited deposit VBN cord-009571-mygj2nd4 349 13 , , , cord-009571-mygj2nd4 349 14 consistent consistent JJ cord-009571-mygj2nd4 349 15 with with IN cord-009571-mygj2nd4 349 16 activation activation NN cord-009571-mygj2nd4 349 17 via via IN cord-009571-mygj2nd4 349 18 the the DT cord-009571-mygj2nd4 349 19 alternative alternative JJ cord-009571-mygj2nd4 349 20 pathway pathway NN cord-009571-mygj2nd4 349 21 , , , cord-009571-mygj2nd4 349 22 was be VBD cord-009571-mygj2nd4 349 23 also also RB cord-009571-mygj2nd4 349 24 studied study VBN cord-009571-mygj2nd4 349 25 , , , cord-009571-mygj2nd4 349 26 as as IN cord-009571-mygj2nd4 349 27 was be VBD cord-009571-mygj2nd4 349 28 one one CD cord-009571-mygj2nd4 349 29 patient patient NN cord-009571-mygj2nd4 349 30 with with IN cord-009571-mygj2nd4 349 31 Goodpasture Goodpasture NNP cord-009571-mygj2nd4 349 32 's 's POS cord-009571-mygj2nd4 349 33 syndrome syndrome NN cord-009571-mygj2nd4 349 34 , , , cord-009571-mygj2nd4 349 35 whose whose WP$ cord-009571-mygj2nd4 349 36 biopsy biopsy NN cord-009571-mygj2nd4 349 37 contained contain VBD cord-009571-mygj2nd4 349 38 linear linear JJ cord-009571-mygj2nd4 349 39 deposits deposit NNS cord-009571-mygj2nd4 349 40 of of IN cord-009571-mygj2nd4 349 41 proteins protein NNS cord-009571-mygj2nd4 349 42 along along IN cord-009571-mygj2nd4 349 43 the the DT cord-009571-mygj2nd4 349 44 glomerular glomerular JJ cord-009571-mygj2nd4 349 45 basement basement NN cord-009571-mygj2nd4 349 46 membrane membrane NN cord-009571-mygj2nd4 349 47 . . . cord-009571-mygj2nd4 350 1 Six six CD cord-009571-mygj2nd4 350 2 specimens specimen NNS cord-009571-mygj2nd4 350 3 from from IN cord-009571-mygj2nd4 350 4 patients patient NNS cord-009571-mygj2nd4 350 5 with with IN cord-009571-mygj2nd4 350 6 such such JJ cord-009571-mygj2nd4 350 7 nonimmune nonimmune JJ cord-009571-mygj2nd4 350 8 renal renal JJ cord-009571-mygj2nd4 350 9 diseases disease NNS cord-009571-mygj2nd4 350 10 as as IN cord-009571-mygj2nd4 350 11 arteriolar arteriolar JJ cord-009571-mygj2nd4 350 12 nephrosclerosis nephrosclerosis NN cord-009571-mygj2nd4 350 13 and and CC cord-009571-mygj2nd4 350 14 acute acute JJ cord-009571-mygj2nd4 350 15 tubular tubular JJ cord-009571-mygj2nd4 350 16 necrosis necrosis NN cord-009571-mygj2nd4 350 17 were be VBD cord-009571-mygj2nd4 350 18 also also RB cord-009571-mygj2nd4 350 19 examined examine VBN cord-009571-mygj2nd4 350 20 . . . cord-009571-mygj2nd4 351 1 By by IN cord-009571-mygj2nd4 351 2 use use NN cord-009571-mygj2nd4 351 3 of of IN cord-009571-mygj2nd4 351 4 direct direct JJ cord-009571-mygj2nd4 351 5 immunofluorescence immunofluorescence NN cord-009571-mygj2nd4 351 6 with with IN cord-009571-mygj2nd4 351 7 anti anti JJ cord-009571-mygj2nd4 351 8 - - NN cord-009571-mygj2nd4 351 9 BlH blh NN cord-009571-mygj2nd4 351 10 specifically specifically RB cord-009571-mygj2nd4 351 11 shown show VBN cord-009571-mygj2nd4 351 12 to to TO cord-009571-mygj2nd4 351 13 be be VB cord-009571-mygj2nd4 351 14 free free JJ cord-009571-mygj2nd4 351 15 of of IN cord-009571-mygj2nd4 351 16 any any DT cord-009571-mygj2nd4 351 17 contaminating contaminate VBG cord-009571-mygj2nd4 351 18 anti anti JJ cord-009571-mygj2nd4 351 19 - - JJ cord-009571-mygj2nd4 351 20 C3 c3 JJ cord-009571-mygj2nd4 351 21 , , , cord-009571-mygj2nd4 351 22 deposits deposit NNS cord-009571-mygj2nd4 351 23 of of IN cord-009571-mygj2nd4 351 24 B1H B1H NNS cord-009571-mygj2nd4 351 25 were be VBD cord-009571-mygj2nd4 351 26 found find VBN cord-009571-mygj2nd4 351 27 in in IN cord-009571-mygj2nd4 351 28 every every DT cord-009571-mygj2nd4 351 29 instance instance NN cord-009571-mygj2nd4 351 30 ( ( -LRB- cord-009571-mygj2nd4 351 31 14 14 CD cord-009571-mygj2nd4 351 32 of of IN cord-009571-mygj2nd4 351 33 14 14 CD cord-009571-mygj2nd4 351 34 exams exam NNS cord-009571-mygj2nd4 351 35 ) ) -RRB- cord-009571-mygj2nd4 351 36 in in IN cord-009571-mygj2nd4 351 37 which which WDT cord-009571-mygj2nd4 351 38 C3 c3 NN cord-009571-mygj2nd4 351 39 deposits deposit NNS cord-009571-mygj2nd4 351 40 were be VBD cord-009571-mygj2nd4 351 41 observed observe VBN cord-009571-mygj2nd4 351 42 . . . cord-009571-mygj2nd4 352 1 This this DT cord-009571-mygj2nd4 352 2 was be VBD cord-009571-mygj2nd4 352 3 true true JJ cord-009571-mygj2nd4 352 4 regardless regardless RB cord-009571-mygj2nd4 352 5 of of IN cord-009571-mygj2nd4 352 6 the the DT cord-009571-mygj2nd4 352 7 underlying underlie VBG cord-009571-mygj2nd4 352 8 disease disease NN cord-009571-mygj2nd4 352 9 which which WDT cord-009571-mygj2nd4 352 10 resulted result VBD cord-009571-mygj2nd4 352 11 in in IN cord-009571-mygj2nd4 352 12 the the DT cord-009571-mygj2nd4 352 13 C3 c3 NN cord-009571-mygj2nd4 352 14 deposits deposit NNS cord-009571-mygj2nd4 352 15 . . . cord-009571-mygj2nd4 353 1 The the DT cord-009571-mygj2nd4 353 2 spatial spatial JJ cord-009571-mygj2nd4 353 3 distribution distribution NN cord-009571-mygj2nd4 353 4 of of IN cord-009571-mygj2nd4 353 5 P p NN cord-009571-mygj2nd4 353 6 l l NN cord-009571-mygj2nd4 353 7 H h NN cord-009571-mygj2nd4 353 8 within within IN cord-009571-mygj2nd4 353 9 the the DT cord-009571-mygj2nd4 353 10 glomerulus glomerulus NN cord-009571-mygj2nd4 353 11 was be VBD cord-009571-mygj2nd4 353 12 often often RB cord-009571-mygj2nd4 353 13 congruent congruent JJ cord-009571-mygj2nd4 353 14 with with IN cord-009571-mygj2nd4 353 15 the the DT cord-009571-mygj2nd4 353 16 distribution distribution NN cord-009571-mygj2nd4 353 17 of of IN cord-009571-mygj2nd4 353 18 C3 c3 NN cord-009571-mygj2nd4 353 19 in in IN cord-009571-mygj2nd4 353 20 the the DT cord-009571-mygj2nd4 353 21 same same JJ cord-009571-mygj2nd4 353 22 tissue tissue NN cord-009571-mygj2nd4 353 23 , , , cord-009571-mygj2nd4 353 24 suggesting suggest VBG cord-009571-mygj2nd4 353 25 that that IN cord-009571-mygj2nd4 353 26 these these DT cord-009571-mygj2nd4 353 27 two two CD cord-009571-mygj2nd4 353 28 proteins protein NNS cord-009571-mygj2nd4 353 29 were be VBD cord-009571-mygj2nd4 353 30 intimately intimately RB cord-009571-mygj2nd4 353 31 associated associate VBN cord-009571-mygj2nd4 353 32 . . . cord-009571-mygj2nd4 354 1 N n NN cord-009571-mygj2nd4 354 2 o o NN cord-009571-mygj2nd4 354 3 deposition deposition NN cord-009571-mygj2nd4 354 4 of of IN cord-009571-mygj2nd4 354 5 B1H b1h NN cord-009571-mygj2nd4 354 6 was be VBD cord-009571-mygj2nd4 354 7 observed observe VBN cord-009571-mygj2nd4 354 8 in in IN cord-009571-mygj2nd4 354 9 those those DT cord-009571-mygj2nd4 354 10 with with IN cord-009571-mygj2nd4 354 11 nonimmune nonimmune JJ cord-009571-mygj2nd4 354 12 renal renal JJ cord-009571-mygj2nd4 354 13 disease disease NN cord-009571-mygj2nd4 354 14 . . . cord-009571-mygj2nd4 355 1 We -PRON- PRP cord-009571-mygj2nd4 355 2 conclude conclude VBP cord-009571-mygj2nd4 355 3 that that IN cord-009571-mygj2nd4 355 4 binding binding NN cord-009571-mygj2nd4 355 5 of of IN cord-009571-mygj2nd4 355 6 / / SYM cord-009571-mygj2nd4 355 7 3 3 CD cord-009571-mygj2nd4 355 8 1H 1h CD cord-009571-mygj2nd4 355 9 to to IN cord-009571-mygj2nd4 355 10 fragments fragment NNS cord-009571-mygj2nd4 355 11 of of IN cord-009571-mygj2nd4 355 12 C3 c3 NN cord-009571-mygj2nd4 355 13 , , , cord-009571-mygj2nd4 355 14 presumably presumably RB cord-009571-mygj2nd4 355 15 C3b C3b NNP cord-009571-mygj2nd4 355 16 , , , cord-009571-mygj2nd4 355 17 occurs occur VBZ cord-009571-mygj2nd4 355 18 in in IN cord-009571-mygj2nd4 355 19 vivo vivo NN cord-009571-mygj2nd4 355 20 during during IN cord-009571-mygj2nd4 355 21 immunologic immunologic JJ cord-009571-mygj2nd4 355 22 activation activation NN cord-009571-mygj2nd4 355 23 of of IN cord-009571-mygj2nd4 355 24 the the DT cord-009571-mygj2nd4 355 25 complement complement NN cord-009571-mygj2nd4 355 26 system system NN cord-009571-mygj2nd4 355 27 , , , cord-009571-mygj2nd4 355 28 just just RB cord-009571-mygj2nd4 355 29 as as IN cord-009571-mygj2nd4 355 30 we -PRON- PRP cord-009571-mygj2nd4 355 31 had have VBD cord-009571-mygj2nd4 355 32 previously previously RB cord-009571-mygj2nd4 355 33 demonstrated demonstrate VBN cord-009571-mygj2nd4 355 34 it -PRON- PRP cord-009571-mygj2nd4 355 35 to to TO cord-009571-mygj2nd4 355 36 occur occur VB cord-009571-mygj2nd4 355 37 in in IN cord-009571-mygj2nd4 355 38 vitro vitro FW cord-009571-mygj2nd4 355 39 . . . cord-009571-mygj2nd4 356 1 Hahn Hahn NNP cord-009571-mygj2nd4 356 2 et et NNP cord-009571-mygj2nd4 356 3 al al NNP cord-009571-mygj2nd4 356 4 . . . cord-009571-mygj2nd4 357 1 ( ( -LRB- cord-009571-mygj2nd4 357 2 Ann Ann NNP cord-009571-mygj2nd4 357 3 Int Int NNP cord-009571-mygj2nd4 357 4 Med Med NNP cord-009571-mygj2nd4 357 5 76365 76365 CD cord-009571-mygj2nd4 357 6 , , , cord-009571-mygj2nd4 357 7 1972 1972 CD cord-009571-mygj2nd4 357 8 ) ) -RRB- cord-009571-mygj2nd4 357 9 have have VBP cord-009571-mygj2nd4 357 10 shown show VBN cord-009571-mygj2nd4 357 11 a a DT cord-009571-mygj2nd4 357 12 relationship relationship NN cord-009571-mygj2nd4 357 13 between between IN cord-009571-mygj2nd4 357 14 anti anti JJ cord-009571-mygj2nd4 357 15 - - NNP cord-009571-mygj2nd4 357 16 Hdz hdz JJ cord-009571-mygj2nd4 357 17 and and CC cord-009571-mygj2nd4 357 18 anti anti JJ cord-009571-mygj2nd4 357 19 - - JJ cord-009571-mygj2nd4 357 20 DNA dna NN cord-009571-mygj2nd4 357 21 in in IN cord-009571-mygj2nd4 357 22 4 4 CD cord-009571-mygj2nd4 357 23 patients patient NNS cord-009571-mygj2nd4 357 24 with with IN cord-009571-mygj2nd4 357 25 Hdz Hdz NNP cord-009571-mygj2nd4 357 26 - - HYPH cord-009571-mygj2nd4 357 27 SLE SLE NNP cord-009571-mygj2nd4 357 28 , , , cord-009571-mygj2nd4 357 29 and and CC cord-009571-mygj2nd4 357 30 Yamauchi Yamauchi NNP cord-009571-mygj2nd4 357 31 et et NNP cord-009571-mygj2nd4 357 32 al al NNP cord-009571-mygj2nd4 357 33 . . . cord-009571-mygj2nd4 358 1 ( ( -LRB- cord-009571-mygj2nd4 358 2 J J NNP cord-009571-mygj2nd4 358 3 Clin Clin NNP cord-009571-mygj2nd4 358 4 Invest Invest NNP cord-009571-mygj2nd4 358 5 56:958 56:958 CD cord-009571-mygj2nd4 358 6 , , , cord-009571-mygj2nd4 358 7 1975 1975 CD cord-009571-mygj2nd4 358 8 ) ) -RRB- cord-009571-mygj2nd4 358 9 have have VBP cord-009571-mygj2nd4 358 10 shown show VBN cord-009571-mygj2nd4 358 11 immunologic immunologic JJ cord-009571-mygj2nd4 358 12 cross cross NN cord-009571-mygj2nd4 358 13 reactivity reactivity NN cord-009571-mygj2nd4 358 14 between between IN cord-009571-mygj2nd4 358 15 DNA DNA NNP cord-009571-mygj2nd4 358 16 and and CC cord-009571-mygj2nd4 358 17 Hdz Hdz NNP cord-009571-mygj2nd4 358 18 with with IN cord-009571-mygj2nd4 358 19 rabbit rabbit NN cord-009571-mygj2nd4 358 20 antisera antisera NN cord-009571-mygj2nd4 358 21 to to IN cord-009571-mygj2nd4 358 22 Hdz hdz NN cord-009571-mygj2nd4 358 23 - - HYPH cord-009571-mygj2nd4 358 24 albumin albumin NN cord-009571-mygj2nd4 358 25 conjugates conjugate NNS cord-009571-mygj2nd4 358 26 . . . cord-009571-mygj2nd4 359 1 To to TO cord-009571-mygj2nd4 359 2 find find VB cord-009571-mygj2nd4 359 3 if if IN cord-009571-mygj2nd4 359 4 the the DT cord-009571-mygj2nd4 359 5 development development NN cord-009571-mygj2nd4 359 6 of of IN cord-009571-mygj2nd4 359 7 antibodies antibody NNS cord-009571-mygj2nd4 359 8 to to IN cord-009571-mygj2nd4 359 9 DNA DNA NNP cord-009571-mygj2nd4 359 10 or or CC cord-009571-mygj2nd4 359 11 DNP dnp NN cord-009571-mygj2nd4 359 12 in in IN cord-009571-mygj2nd4 359 13 patients patient NNS cord-009571-mygj2nd4 359 14 taking take VBG cord-009571-mygj2nd4 359 15 Hdz Hdz NNP cord-009571-mygj2nd4 359 16 represents represent VBZ cord-009571-mygj2nd4 359 17 the the DT cord-009571-mygj2nd4 359 18 production production NN cord-009571-mygj2nd4 359 19 of of IN cord-009571-mygj2nd4 359 20 anti anti JJ cord-009571-mygj2nd4 359 21 - - NNP cord-009571-mygj2nd4 359 22 Hdz Hdz NNP cord-009571-mygj2nd4 359 23 which which WDT cord-009571-mygj2nd4 359 24 cross cross NN cord-009571-mygj2nd4 359 25 reacts react VBZ cord-009571-mygj2nd4 359 26 with with IN cord-009571-mygj2nd4 359 27 DNA DNA NNP cord-009571-mygj2nd4 359 28 / / SYM cord-009571-mygj2nd4 359 29 DNP DNP NNP cord-009571-mygj2nd4 359 30 determinants determinant NNS cord-009571-mygj2nd4 359 31 , , , cord-009571-mygj2nd4 359 32 we -PRON- PRP cord-009571-mygj2nd4 359 33 followed follow VBD cord-009571-mygj2nd4 359 34 prospectively prospectively RB cord-009571-mygj2nd4 359 35 2 2 CD cord-009571-mygj2nd4 359 36 1 1 CD cord-009571-mygj2nd4 359 37 hypertensive hypertensive JJ cord-009571-mygj2nd4 359 38 patients patient NNS cord-009571-mygj2nd4 359 39 taking take VBG cord-009571-mygj2nd4 359 40 this this DT cord-009571-mygj2nd4 359 41 drug drug NN cord-009571-mygj2nd4 359 42 ( ( -LRB- cord-009571-mygj2nd4 359 43 average average JJ cord-009571-mygj2nd4 359 44 dose dose NN cord-009571-mygj2nd4 359 45 100 100 CD cord-009571-mygj2nd4 359 46 mg mg NNP cord-009571-mygj2nd4 359 47 / / SYM cord-009571-mygj2nd4 359 48 day day NN cord-009571-mygj2nd4 359 49 ) ) -RRB- cord-009571-mygj2nd4 359 50 for for IN cord-009571-mygj2nd4 359 51 one one CD cord-009571-mygj2nd4 359 52 year year NN cord-009571-mygj2nd4 359 53 . . . cord-009571-mygj2nd4 360 1 Antibodies antibody NNS cord-009571-mygj2nd4 360 2 to to IN cord-009571-mygj2nd4 360 3 Hdz Hdz NNP cord-009571-mygj2nd4 360 4 were be VBD cord-009571-mygj2nd4 360 5 measured measure VBN cord-009571-mygj2nd4 360 6 by by IN cord-009571-mygj2nd4 360 7 passive passive JJ cord-009571-mygj2nd4 360 8 hemagglutination hemagglutination NN cord-009571-mygj2nd4 360 9 , , , cord-009571-mygj2nd4 360 10 to to IN cord-009571-mygj2nd4 360 11 native native JJ cord-009571-mygj2nd4 360 12 DNA dna NN cord-009571-mygj2nd4 360 13 by by IN cord-009571-mygj2nd4 361 1 In in IN cord-009571-mygj2nd4 361 2 the the DT cord-009571-mygj2nd4 361 3 prospective prospective JJ cord-009571-mygj2nd4 361 4 group group NN cord-009571-mygj2nd4 361 5 the the DT cord-009571-mygj2nd4 361 6 major major JJ cord-009571-mygj2nd4 361 7 finding finding NN cord-009571-mygj2nd4 361 8 was be VBD cord-009571-mygj2nd4 361 9 development development NN cord-009571-mygj2nd4 361 10 of of IN cord-009571-mygj2nd4 361 11 increased increase VBN cord-009571-mygj2nd4 361 12 levels level NNS cord-009571-mygj2nd4 361 13 of of IN cord-009571-mygj2nd4 361 14 anti anti JJ cord-009571-mygj2nd4 361 15 - - JJ cord-009571-mygj2nd4 361 16 DNP DNP NNP cord-009571-mygj2nd4 361 17 in in IN cord-009571-mygj2nd4 361 18 8 8 CD cord-009571-mygj2nd4 361 19 patients patient NNS cord-009571-mygj2nd4 361 20 , , , cord-009571-mygj2nd4 361 21 7 7 CD cord-009571-mygj2nd4 361 22 of of IN cord-009571-mygj2nd4 361 23 whom whom WP cord-009571-mygj2nd4 361 24 also also RB cord-009571-mygj2nd4 361 25 made make VBD cord-009571-mygj2nd4 361 26 anti anti JJ cord-009571-mygj2nd4 361 27 - - NNP cord-009571-mygj2nd4 361 28 Hdz Hdz NNP cord-009571-mygj2nd4 361 29 . . . cord-009571-mygj2nd4 362 1 Nine nine CD cord-009571-mygj2nd4 362 2 other other JJ cord-009571-mygj2nd4 362 3 patients patient NNS cord-009571-mygj2nd4 362 4 made make VBD cord-009571-mygj2nd4 362 5 anti anti JJ cord-009571-mygj2nd4 362 6 - - NNP cord-009571-mygj2nd4 362 7 Hdz Hdz NNP cord-009571-mygj2nd4 362 8 without without IN cord-009571-mygj2nd4 362 9 anti anti JJ cord-009571-mygj2nd4 362 10 - - JJ cord-009571-mygj2nd4 362 11 DNP DNP NNP cord-009571-mygj2nd4 362 12 . . . cord-009571-mygj2nd4 363 1 None none NN cord-009571-mygj2nd4 363 2 made make VBD cord-009571-mygj2nd4 363 3 anti anti JJ cord-009571-mygj2nd4 363 4 - - JJ cord-009571-mygj2nd4 363 5 nDNA ndna JJ cord-009571-mygj2nd4 363 6 . . . cord-009571-mygj2nd4 364 1 One one CD cord-009571-mygj2nd4 364 2 developed develop VBD cord-009571-mygj2nd4 364 3 a a DT cord-009571-mygj2nd4 364 4 mild mild JJ cord-009571-mygj2nd4 364 5 Hdz Hdz NNP cord-009571-mygj2nd4 364 6 - - HYPH cord-009571-mygj2nd4 364 7 SLE SLE NNP cord-009571-mygj2nd4 364 8 syndrome syndrome NN cord-009571-mygj2nd4 364 9 with with IN cord-009571-mygj2nd4 364 10 anti anti JJ cord-009571-mygj2nd4 364 11 - - NNP cord-009571-mygj2nd4 364 12 Hdz hdz JJ cord-009571-mygj2nd4 364 13 and and CC cord-009571-mygj2nd4 364 14 anti anti JJ cord-009571-mygj2nd4 364 15 - - JJ cord-009571-mygj2nd4 364 16 DNP DNP NNP cord-009571-mygj2nd4 364 17 . . . cord-009571-mygj2nd4 365 1 Examination examination NN cord-009571-mygj2nd4 365 2 of of IN cord-009571-mygj2nd4 365 3 sera sera NNP cord-009571-mygj2nd4 365 4 of of IN cord-009571-mygj2nd4 365 5 4 4 CD cord-009571-mygj2nd4 365 6 other other JJ cord-009571-mygj2nd4 365 7 patients patient NNS cord-009571-mygj2nd4 365 8 with with IN cord-009571-mygj2nd4 365 9 Hdz Hdz NNP cord-009571-mygj2nd4 365 10 - - HYPH cord-009571-mygj2nd4 365 11 SLE SLE NNP cord-009571-mygj2nd4 365 12 syndrome syndrome NN cord-009571-mygj2nd4 365 13 by by IN cord-009571-mygj2nd4 365 14 radioimmunoassay radioimmunoassay NN cord-009571-mygj2nd4 365 15 failed fail VBD cord-009571-mygj2nd4 365 16 to to TO cord-009571-mygj2nd4 365 17 show show VB cord-009571-mygj2nd4 365 18 an an DT cord-009571-mygj2nd4 365 19 immunologic immunologic JJ cord-009571-mygj2nd4 365 20 cross cross NN cord-009571-mygj2nd4 365 21 reaction reaction NN cord-009571-mygj2nd4 365 22 between between IN cord-009571-mygj2nd4 365 23 Hdz Hdz NNP cord-009571-mygj2nd4 365 24 and and CC cord-009571-mygj2nd4 365 25 DNP DNP NNP cord-009571-mygj2nd4 365 26 although although IN cord-009571-mygj2nd4 365 27 such such PDT cord-009571-mygj2nd4 365 28 a a DT cord-009571-mygj2nd4 365 29 reaction reaction NN cord-009571-mygj2nd4 365 30 was be VBD cord-009571-mygj2nd4 365 31 found find VBN cord-009571-mygj2nd4 365 32 in in IN cord-009571-mygj2nd4 365 33 guinea guinea NN cord-009571-mygj2nd4 365 34 pig pig NN cord-009571-mygj2nd4 365 35 anti anti NNP cord-009571-mygj2nd4 365 36 - - NNP cord-009571-mygj2nd4 365 37 Hdz Hdz NNP cord-009571-mygj2nd4 365 38 - - HYPH cord-009571-mygj2nd4 365 39 BSA BSA NNP cord-009571-mygj2nd4 365 40 serum serum NN cord-009571-mygj2nd4 365 41 . . . cord-009571-mygj2nd4 366 1 The the DT cord-009571-mygj2nd4 366 2 results result NNS cord-009571-mygj2nd4 366 3 show show VBP cord-009571-mygj2nd4 366 4 a a DT cord-009571-mygj2nd4 366 5 relationship relationship NN cord-009571-mygj2nd4 366 6 between between IN cord-009571-mygj2nd4 366 7 production production NN cord-009571-mygj2nd4 366 8 of of IN cord-009571-mygj2nd4 366 9 antibody antibody NN cord-009571-mygj2nd4 366 10 to to IN cord-009571-mygj2nd4 366 11 Hdz Hdz NNP cord-009571-mygj2nd4 366 12 and and CC cord-009571-mygj2nd4 366 13 to to IN cord-009571-mygj2nd4 366 14 DNP dnp VB cord-009571-mygj2nd4 366 15 in in IN cord-009571-mygj2nd4 366 16 patients patient NNS cord-009571-mygj2nd4 366 17 taking take VBG cord-009571-mygj2nd4 366 18 Hdz Hdz NNP cord-009571-mygj2nd4 366 19 but but CC cord-009571-mygj2nd4 366 20 do do VBP cord-009571-mygj2nd4 366 21 not not RB cord-009571-mygj2nd4 366 22 support support VB cord-009571-mygj2nd4 366 23 the the DT cord-009571-mygj2nd4 366 24 hypothesis hypothesis NN cord-009571-mygj2nd4 366 25 that that IN cord-009571-mygj2nd4 366 26 anti anti JJ cord-009571-mygj2nd4 366 27 - - JJ cord-009571-mygj2nd4 366 28 DNP DNP NNP cord-009571-mygj2nd4 366 29 in in IN cord-009571-mygj2nd4 366 30 such such JJ cord-009571-mygj2nd4 366 31 patients patient NNS cord-009571-mygj2nd4 366 32 is be VBZ cord-009571-mygj2nd4 366 33 antibody antibody NN cord-009571-mygj2nd4 366 34 cross cross NN cord-009571-mygj2nd4 366 35 reacting react VBG cord-009571-mygj2nd4 366 36 with with IN cord-009571-mygj2nd4 366 37 Hdz Hdz NNP cord-009571-mygj2nd4 366 38 . . . cord-009571-mygj2nd4 367 1 They -PRON- PRP cord-009571-mygj2nd4 367 2 are be VBP cord-009571-mygj2nd4 367 3 consistent consistent JJ cord-009571-mygj2nd4 367 4 with with IN cord-009571-mygj2nd4 367 5 the the DT cord-009571-mygj2nd4 367 6 findings finding NNS cord-009571-mygj2nd4 367 7 of of IN cord-009571-mygj2nd4 367 8 Fritzler Fritzler NNP cord-009571-mygj2nd4 367 9 and and CC cord-009571-mygj2nd4 367 10 Tan Tan NNP cord-009571-mygj2nd4 367 11 ( ( -LRB- cord-009571-mygj2nd4 367 12 Clin Clin NNP cord-009571-mygj2nd4 367 13 Res Res NNP cord-009571-mygj2nd4 367 14 25 25 CD cord-009571-mygj2nd4 367 15 : : : cord-009571-mygj2nd4 367 16 A483 a483 ADD cord-009571-mygj2nd4 367 17 , , , cord-009571-mygj2nd4 367 18 1977 1977 CD cord-009571-mygj2nd4 367 19 ) ) -RRB- cord-009571-mygj2nd4 367 20 that that IN cord-009571-mygj2nd4 367 21 anti anti JJ cord-009571-mygj2nd4 367 22 - - JJ cord-009571-mygj2nd4 367 23 DNP dnp JJ cord-009571-mygj2nd4 367 24 in in IN cord-009571-mygj2nd4 367 25 drug drug NN cord-009571-mygj2nd4 367 26 - - HYPH cord-009571-mygj2nd4 367 27 related relate VBN cord-009571-mygj2nd4 367 28 SLE SLE NNP cord-009571-mygj2nd4 367 29 reacts react VBZ cord-009571-mygj2nd4 367 30 with with IN cord-009571-mygj2nd4 367 31 the the DT cord-009571-mygj2nd4 367 32 histone histone NN cord-009571-mygj2nd4 367 33 moiety moiety NN cord-009571-mygj2nd4 367 34 . . . cord-009571-mygj2nd4 368 1 The the DT cord-009571-mygj2nd4 368 2 relationship relationship NN cord-009571-mygj2nd4 368 3 of of IN cord-009571-mygj2nd4 368 4 the the DT cord-009571-mygj2nd4 368 5 immune immune JJ cord-009571-mygj2nd4 368 6 response response NN cord-009571-mygj2nd4 368 7 to to IN cord-009571-mygj2nd4 368 8 Hdz Hdz NNP cord-009571-mygj2nd4 368 9 to to IN cord-009571-mygj2nd4 368 10 that that DT cord-009571-mygj2nd4 368 11 to to IN cord-009571-mygj2nd4 368 12 DNP DNP NNP cord-009571-mygj2nd4 368 13 remains remain VBZ cord-009571-mygj2nd4 368 14 unexplained unexplained JJ cord-009571-mygj2nd4 368 15 . . . cord-009571-mygj2nd4 369 1 Anti anti JJ cord-009571-mygj2nd4 369 2 - - JJ cord-009571-mygj2nd4 369 3 idiotypic idiotypic JJ cord-009571-mygj2nd4 369 4 antibodies antibody NNS cord-009571-mygj2nd4 369 5 recognize recognize VBP cord-009571-mygj2nd4 369 6 antigenic antigenic JJ cord-009571-mygj2nd4 369 7 determinants determinant NNS cord-009571-mygj2nd4 369 8 ( ( -LRB- cord-009571-mygj2nd4 369 9 idiotypes idiotype NNS cord-009571-mygj2nd4 369 10 ) ) -RRB- cord-009571-mygj2nd4 369 11 uniquely uniquely RB cord-009571-mygj2nd4 369 12 associated associate VBN cord-009571-mygj2nd4 369 13 with with IN cord-009571-mygj2nd4 369 14 a a DT cord-009571-mygj2nd4 369 15 given give VBN cord-009571-mygj2nd4 369 16 antibody antibody NN cord-009571-mygj2nd4 369 17 molecule molecule NN cord-009571-mygj2nd4 369 18 , , , cord-009571-mygj2nd4 369 19 or or CC cord-009571-mygj2nd4 369 20 closely closely RB cord-009571-mygj2nd4 369 21 related related JJ cord-009571-mygj2nd4 369 22 molecules molecule NNS cord-009571-mygj2nd4 369 23 . . . cord-009571-mygj2nd4 370 1 The the DT cord-009571-mygj2nd4 370 2 in in IN cord-009571-mygj2nd4 370 3 vivo vivo NN cord-009571-mygj2nd4 370 4 interaction interaction NN cord-009571-mygj2nd4 370 5 between between IN cord-009571-mygj2nd4 370 6 idiotypes idiotype NNS cord-009571-mygj2nd4 370 7 and and CC cord-009571-mygj2nd4 370 8 anti anti NNP cord-009571-mygj2nd4 370 9 - - JJ cord-009571-mygj2nd4 370 10 idiotypic idiotypic JJ cord-009571-mygj2nd4 370 11 antibodies antibody NNS cord-009571-mygj2nd4 370 12 has have VBZ cord-009571-mygj2nd4 370 13 been be VBN cord-009571-mygj2nd4 370 14 postulated postulate VBN cord-009571-mygj2nd4 370 15 to to TO cord-009571-mygj2nd4 370 16 play play VB cord-009571-mygj2nd4 370 17 a a DT cord-009571-mygj2nd4 370 18 central central JJ cord-009571-mygj2nd4 370 19 role role NN cord-009571-mygj2nd4 370 20 in in IN cord-009571-mygj2nd4 370 21 the the DT cord-009571-mygj2nd4 370 22 regulation regulation NN cord-009571-mygj2nd4 370 23 of of IN cord-009571-mygj2nd4 370 24 the the DT cord-009571-mygj2nd4 370 25 immune immune JJ cord-009571-mygj2nd4 370 26 system system NN cord-009571-mygj2nd4 370 27 . . . cord-009571-mygj2nd4 371 1 The the DT cord-009571-mygj2nd4 371 2 purpose purpose NN cord-009571-mygj2nd4 371 3 of of IN cord-009571-mygj2nd4 371 4 this this DT cord-009571-mygj2nd4 371 5 study study NN cord-009571-mygj2nd4 371 6 was be VBD cord-009571-mygj2nd4 371 7 to to TO cord-009571-mygj2nd4 371 8 characterize characterize VB cord-009571-mygj2nd4 371 9 the the DT cord-009571-mygj2nd4 371 10 idiotypic idiotypic NNP cord-009571-mygj2nd4 371 11 antigens antigen NNS cord-009571-mygj2nd4 371 12 on on IN cord-009571-mygj2nd4 371 13 three three CD cord-009571-mygj2nd4 371 14 monoclonal monoclonal JJ cord-009571-mygj2nd4 371 15 IgM IgM NNP cord-009571-mygj2nd4 371 16 anti anti NNP cord-009571-mygj2nd4 371 17 - - NNP cord-009571-mygj2nd4 371 18 y y NNP cord-009571-mygj2nd4 371 19 - - HYPH cord-009571-mygj2nd4 371 20 globulins globulins NNP cord-009571-mygj2nd4 371 21 and and CC cord-009571-mygj2nd4 371 22 to to TO cord-009571-mygj2nd4 371 23 determine determine VB cord-009571-mygj2nd4 371 24 if if IN cord-009571-mygj2nd4 371 25 cross cross NN cord-009571-mygj2nd4 371 26 - - JJ cord-009571-mygj2nd4 371 27 reacting react VBG cord-009571-mygj2nd4 371 28 idiotypes idiotype NNS cord-009571-mygj2nd4 371 29 were be VBD cord-009571-mygj2nd4 371 30 present present JJ cord-009571-mygj2nd4 371 31 in in IN cord-009571-mygj2nd4 371 32 the the DT cord-009571-mygj2nd4 371 33 sera sera NNP cord-009571-mygj2nd4 371 34 of of IN cord-009571-mygj2nd4 371 35 patients patient NNS cord-009571-mygj2nd4 371 36 with with IN cord-009571-mygj2nd4 371 37 rheumatoid rheumatoid NN cord-009571-mygj2nd4 371 38 arthritis arthritis NN cord-009571-mygj2nd4 371 39 ( ( -LRB- cord-009571-mygj2nd4 371 40 RA RA NNP cord-009571-mygj2nd4 371 41 ) ) -RRB- cord-009571-mygj2nd4 371 42 . . . cord-009571-mygj2nd4 372 1 Anti anti JJ cord-009571-mygj2nd4 372 2 - - JJ cord-009571-mygj2nd4 372 3 idiotypic idiotypic JJ cord-009571-mygj2nd4 372 4 antibodies antibody NNS cord-009571-mygj2nd4 372 5 against against IN cord-009571-mygj2nd4 372 6 the the DT cord-009571-mygj2nd4 372 7 purified purify VBN cord-009571-mygj2nd4 372 8 IgM igm NN cord-009571-mygj2nd4 372 9 ( ( -LRB- cord-009571-mygj2nd4 372 10 K K NNP cord-009571-mygj2nd4 372 11 ) ) -RRB- cord-009571-mygj2nd4 372 12 anti anti NNP cord-009571-mygj2nd4 372 13 - - JJ cord-009571-mygj2nd4 372 14 y y JJ cord-009571-mygj2nd4 372 15 - - HYPH cord-009571-mygj2nd4 372 16 globulins globulins NNP cord-009571-mygj2nd4 372 17 Lay Lay NNP cord-009571-mygj2nd4 372 18 and and CC cord-009571-mygj2nd4 372 19 Si Si NNP cord-009571-mygj2nd4 372 20 , , , cord-009571-mygj2nd4 372 21 and and CC cord-009571-mygj2nd4 372 22 the the DT cord-009571-mygj2nd4 372 23 IgM IgM NNP cord-009571-mygj2nd4 372 24 ( ( -LRB- cord-009571-mygj2nd4 372 25 A A NNP cord-009571-mygj2nd4 372 26 ) ) -RRB- cord-009571-mygj2nd4 372 27 anti anti JJ cord-009571-mygj2nd4 372 28 - - JJ cord-009571-mygj2nd4 372 29 y y JJ cord-009571-mygj2nd4 372 30 - - HYPH cord-009571-mygj2nd4 372 31 globulin globulin NN cord-009571-mygj2nd4 372 32 Koh Koh NNP cord-009571-mygj2nd4 372 33 , , , cord-009571-mygj2nd4 372 34 were be VBD cord-009571-mygj2nd4 372 35 raised raise VBN cord-009571-mygj2nd4 372 36 in in IN cord-009571-mygj2nd4 372 37 rabbits rabbit NNS cord-009571-mygj2nd4 372 38 . . . cord-009571-mygj2nd4 373 1 When when WRB cord-009571-mygj2nd4 373 2 analyzed analyze VBN cord-009571-mygj2nd4 373 3 by by IN cord-009571-mygj2nd4 373 4 solid solid JJ cord-009571-mygj2nd4 373 5 phase phase NN cord-009571-mygj2nd4 373 6 radioimmunoassay radioimmunoassay JJ cord-009571-mygj2nd4 373 7 ( ( -LRB- cord-009571-mygj2nd4 373 8 RIA RIA NNP cord-009571-mygj2nd4 373 9 ) ) -RRB- cord-009571-mygj2nd4 373 10 , , , cord-009571-mygj2nd4 373 11 each each DT cord-009571-mygj2nd4 373 12 antibody antibody NN cord-009571-mygj2nd4 373 13 reacted react VBD cord-009571-mygj2nd4 373 14 only only RB cord-009571-mygj2nd4 373 15 with with IN cord-009571-mygj2nd4 373 16 the the DT cord-009571-mygj2nd4 373 17 immunizing immunize VBG cord-009571-mygj2nd4 373 18 antigen antigen NN cord-009571-mygj2nd4 373 19 , , , cord-009571-mygj2nd4 373 20 and and CC cord-009571-mygj2nd4 373 21 not not RB cord-009571-mygj2nd4 373 22 with with IN cord-009571-mygj2nd4 373 23 pooled pool VBN cord-009571-mygj2nd4 373 24 IgG igg NN cord-009571-mygj2nd4 373 25 or or CC cord-009571-mygj2nd4 373 26 other other JJ cord-009571-mygj2nd4 373 27 IgM IgM NNP cord-009571-mygj2nd4 373 28 paraproteins paraproteins NNP cord-009571-mygj2nd4 373 29 lacking lack VBG cord-009571-mygj2nd4 373 30 anti anti NNP cord-009571-mygj2nd4 373 31 - - JJ cord-009571-mygj2nd4 373 32 y y JJ cord-009571-mygj2nd4 373 33 - - HYPH cord-009571-mygj2nd4 373 34 globulin globulin NN cord-009571-mygj2nd4 373 35 activity activity NN cord-009571-mygj2nd4 373 36 . . . cord-009571-mygj2nd4 374 1 Studies study NNS cord-009571-mygj2nd4 374 2 with with IN cord-009571-mygj2nd4 374 3 recombinant recombinant JJ cord-009571-mygj2nd4 374 4 molecules molecule NNS cord-009571-mygj2nd4 374 5 reconstructed reconstruct VBN cord-009571-mygj2nd4 374 6 from from IN cord-009571-mygj2nd4 374 7 Lay Lay NNP cord-009571-mygj2nd4 374 8 or or CC cord-009571-mygj2nd4 374 9 Si Si NNP cord-009571-mygj2nd4 374 10 light light NN cord-009571-mygj2nd4 374 11 or or CC cord-009571-mygj2nd4 374 12 heavy heavy JJ cord-009571-mygj2nd4 374 13 chains chain NNS cord-009571-mygj2nd4 374 14 and and CC cord-009571-mygj2nd4 374 15 light light NN cord-009571-mygj2nd4 374 16 or or CC cord-009571-mygj2nd4 374 17 heavy heavy JJ cord-009571-mygj2nd4 374 18 chains chain NNS cord-009571-mygj2nd4 374 19 from from IN cord-009571-mygj2nd4 374 20 heterologous heterologous JJ cord-009571-mygj2nd4 374 21 proteins protein NNS cord-009571-mygj2nd4 374 22 demonstrated demonstrate VBD cord-009571-mygj2nd4 374 23 that that IN cord-009571-mygj2nd4 374 24 the the DT cord-009571-mygj2nd4 374 25 idiotypic idiotypic NNP cord-009571-mygj2nd4 374 26 antigens antigen NNS cord-009571-mygj2nd4 374 27 were be VBD cord-009571-mygj2nd4 374 28 formed form VBN cord-009571-mygj2nd4 374 29 from from IN cord-009571-mygj2nd4 374 30 a a DT cord-009571-mygj2nd4 374 31 specific specific JJ cord-009571-mygj2nd4 374 32 heavy heavy JJ cord-009571-mygj2nd4 374 33 - - HYPH cord-009571-mygj2nd4 374 34 light light NN cord-009571-mygj2nd4 374 35 chain chain NN cord-009571-mygj2nd4 374 36 interaction interaction NN cord-009571-mygj2nd4 374 37 . . . cord-009571-mygj2nd4 375 1 The the DT cord-009571-mygj2nd4 375 2 idiotypes idiotype NNS cord-009571-mygj2nd4 375 3 were be VBD cord-009571-mygj2nd4 375 4 closely closely RB cord-009571-mygj2nd4 375 5 related relate VBN cord-009571-mygj2nd4 375 6 to to IN cord-009571-mygj2nd4 375 7 the the DT cord-009571-mygj2nd4 375 8 antibody antibody NN cord-009571-mygj2nd4 375 9 combining combine VBG cord-009571-mygj2nd4 375 10 site site NN cord-009571-mygj2nd4 375 11 , , , cord-009571-mygj2nd4 375 12 as as IN cord-009571-mygj2nd4 375 13 judged judge VBN cord-009571-mygj2nd4 375 14 by by IN cord-009571-mygj2nd4 375 15 the the DT cord-009571-mygj2nd4 375 16 inhibition inhibition NN cord-009571-mygj2nd4 375 17 of of IN cord-009571-mygj2nd4 375 18 idiotype idiotype NN cord-009571-mygj2nd4 375 19 - - HYPH cord-009571-mygj2nd4 375 20 anti anti JJ cord-009571-mygj2nd4 375 21 - - JJ cord-009571-mygj2nd4 375 22 idiotype idiotype JJ cord-009571-mygj2nd4 375 23 binding bind VBG cord-009571-mygj2nd4 375 24 by by IN cord-009571-mygj2nd4 375 25 antigen antigen NN cord-009571-mygj2nd4 375 26 , , , cord-009571-mygj2nd4 375 27 i.e. i.e. FW cord-009571-mygj2nd4 375 28 , , , cord-009571-mygj2nd4 375 29 IgG IgG NNP cord-009571-mygj2nd4 375 30 , , , cord-009571-mygj2nd4 375 31 and and CC cord-009571-mygj2nd4 375 32 of of IN cord-009571-mygj2nd4 375 33 idiotype idiotype NN cord-009571-mygj2nd4 375 34 - - HYPH cord-009571-mygj2nd4 375 35 antigen antigen NN cord-009571-mygj2nd4 375 36 binding binding NN cord-009571-mygj2nd4 375 37 by by IN cord-009571-mygj2nd4 375 38 anti anti JJ cord-009571-mygj2nd4 375 39 - - JJ cord-009571-mygj2nd4 375 40 idiotype idiotype NN cord-009571-mygj2nd4 375 41 . . . cord-009571-mygj2nd4 376 1 Idiotypes Idiotypes NNP cord-009571-mygj2nd4 376 2 cross cross NN cord-009571-mygj2nd4 376 3 - - NN cord-009571-mygj2nd4 376 4 reacting react VBG cord-009571-mygj2nd4 376 5 with with IN cord-009571-mygj2nd4 376 6 the the DT cord-009571-mygj2nd4 376 7 monoclonal monoclonal JJ cord-009571-mygj2nd4 376 8 IgM igm NN cord-009571-mygj2nd4 376 9 ( ( -LRB- cord-009571-mygj2nd4 376 10 K K NNP cord-009571-mygj2nd4 376 11 ) ) -RRB- cord-009571-mygj2nd4 376 12 anti anti JJ cord-009571-mygj2nd4 376 13 - - JJ cord-009571-mygj2nd4 376 14 yglobulin yglobulin JJ cord-009571-mygj2nd4 376 15 Si Si NNP cord-009571-mygj2nd4 376 16 , , , cord-009571-mygj2nd4 376 17 but but CC cord-009571-mygj2nd4 376 18 not not RB cord-009571-mygj2nd4 376 19 with with IN cord-009571-mygj2nd4 376 20 the the DT cord-009571-mygj2nd4 376 21 IgM IgM NNP cord-009571-mygj2nd4 376 22 ( ( -LRB- cord-009571-mygj2nd4 376 23 A A NNP cord-009571-mygj2nd4 376 24 ) ) -RRB- cord-009571-mygj2nd4 376 25 anti anti JJ cord-009571-mygj2nd4 376 26 - - JJ cord-009571-mygj2nd4 376 27 y y JJ cord-009571-mygj2nd4 376 28 - - HYPH cord-009571-mygj2nd4 376 29 globulin globulin NN cord-009571-mygj2nd4 376 30 Koh Koh NNP cord-009571-mygj2nd4 376 31 , , , cord-009571-mygj2nd4 376 32 were be VBD cord-009571-mygj2nd4 376 33 found find VBN cord-009571-mygj2nd4 376 34 in in IN cord-009571-mygj2nd4 376 35 increased increase VBN cord-009571-mygj2nd4 376 36 concentration concentration NN cord-009571-mygj2nd4 376 37 in in IN cord-009571-mygj2nd4 376 38 the the DT cord-009571-mygj2nd4 376 39 sera sera NNP cord-009571-mygj2nd4 376 40 of of IN cord-009571-mygj2nd4 376 41 patients patient NNS cord-009571-mygj2nd4 376 42 with with IN cord-009571-mygj2nd4 376 43 seropositive seropositive JJ cord-009571-mygj2nd4 376 44 RA ra NN cord-009571-mygj2nd4 376 45 . . . cord-009571-mygj2nd4 377 1 The the DT cord-009571-mygj2nd4 377 2 idiotype idiotype NN cord-009571-mygj2nd4 377 3 positive positive JJ cord-009571-mygj2nd4 377 4 material material NN cord-009571-mygj2nd4 377 5 , , , cord-009571-mygj2nd4 377 6 as as IN cord-009571-mygj2nd4 377 7 analyzed analyze VBN cord-009571-mygj2nd4 377 8 by by IN cord-009571-mygj2nd4 377 9 gel gel NN cord-009571-mygj2nd4 377 10 filtration filtration NN cord-009571-mygj2nd4 377 11 , , , cord-009571-mygj2nd4 377 12 was be VBD cord-009571-mygj2nd4 377 13 found find VBN cord-009571-mygj2nd4 377 14 in in IN cord-009571-mygj2nd4 377 15 the the DT cord-009571-mygj2nd4 377 16 19s 19 NNS cord-009571-mygj2nd4 377 17 but but CC cord-009571-mygj2nd4 377 18 not not RB cord-009571-mygj2nd4 377 19 the the DT cord-009571-mygj2nd4 377 20 7s 7s NNP cord-009571-mygj2nd4 377 21 fraction fraction NN cord-009571-mygj2nd4 377 22 of of IN cord-009571-mygj2nd4 377 23 serum serum NN cord-009571-mygj2nd4 377 24 . . . cord-009571-mygj2nd4 378 1 From from IN cord-009571-mygj2nd4 378 2 these these DT cord-009571-mygj2nd4 378 3 experiments experiment NNS cord-009571-mygj2nd4 378 4 we -PRON- PRP cord-009571-mygj2nd4 378 5 conclude conclude VBP cord-009571-mygj2nd4 378 6 : : : cord-009571-mygj2nd4 378 7 1 1 LS cord-009571-mygj2nd4 378 8 ) ) -RRB- cord-009571-mygj2nd4 378 9 that that IN cord-009571-mygj2nd4 378 10 the the DT cord-009571-mygj2nd4 378 11 idiotypes idiotype NNS cord-009571-mygj2nd4 378 12 on on IN cord-009571-mygj2nd4 378 13 IgM IgM NNP cord-009571-mygj2nd4 378 14 anti anti NNP cord-009571-mygj2nd4 378 15 - - NNP cord-009571-mygj2nd4 378 16 y y NNP cord-009571-mygj2nd4 378 17 - - HYPH cord-009571-mygj2nd4 378 18 globulins globulins NNP cord-009571-mygj2nd4 378 19 are be VBP cord-009571-mygj2nd4 378 20 associated associate VBN cord-009571-mygj2nd4 378 21 with with IN cord-009571-mygj2nd4 378 22 the the DT cord-009571-mygj2nd4 378 23 antibody antibody NN cord-009571-mygj2nd4 378 24 binding bind VBG cord-009571-mygj2nd4 378 25 site site NN cord-009571-mygj2nd4 378 26 and and CC cord-009571-mygj2nd4 378 27 are be VBP cord-009571-mygj2nd4 378 28 the the DT cord-009571-mygj2nd4 378 29 product product NN cord-009571-mygj2nd4 378 30 of of IN cord-009571-mygj2nd4 378 31 a a DT cord-009571-mygj2nd4 378 32 specific specific JJ cord-009571-mygj2nd4 378 33 light light JJ cord-009571-mygj2nd4 378 34 - - HYPH cord-009571-mygj2nd4 378 35 heavy heavy JJ cord-009571-mygj2nd4 378 36 chain chain NN cord-009571-mygj2nd4 378 37 combination combination NN cord-009571-mygj2nd4 378 38 ; ; : cord-009571-mygj2nd4 378 39 2 2 LS cord-009571-mygj2nd4 378 40 ) ) -RRB- cord-009571-mygj2nd4 378 41 IgM IgM NNP cord-009571-mygj2nd4 378 42 rheumatoid rheumatoid NN cord-009571-mygj2nd4 378 43 factors factor NNS cord-009571-mygj2nd4 378 44 in in IN cord-009571-mygj2nd4 378 45 RA RA NNP cord-009571-mygj2nd4 378 46 patients patient NNS cord-009571-mygj2nd4 378 47 , , , cord-009571-mygj2nd4 378 48 although although IN cord-009571-mygj2nd4 378 49 polyclonal polyclonal JJ cord-009571-mygj2nd4 378 50 , , , cord-009571-mygj2nd4 378 51 may may MD cord-009571-mygj2nd4 378 52 have have VB cord-009571-mygj2nd4 378 53 idiotypic idiotypic NNP cord-009571-mygj2nd4 378 54 antigens antigens NNP cord-009571-mygj2nd4 378 55 cross cross NN cord-009571-mygj2nd4 378 56 - - NN cord-009571-mygj2nd4 378 57 reacting react VBG cord-009571-mygj2nd4 378 58 with with IN cord-009571-mygj2nd4 378 59 those those DT cord-009571-mygj2nd4 378 60 on on IN cord-009571-mygj2nd4 378 61 monoclonal monoclonal JJ cord-009571-mygj2nd4 378 62 IgM igm NN cord-009571-mygj2nd4 378 63 ( ( -LRB- cord-009571-mygj2nd4 378 64 K K NNP cord-009571-mygj2nd4 378 65 ) ) -RRB- cord-009571-mygj2nd4 378 66 anti anti NNP cord-009571-mygj2nd4 378 67 - - JJ cord-009571-mygj2nd4 378 68 y y JJ cord-009571-mygj2nd4 378 69 - - HYPH cord-009571-mygj2nd4 378 70 globulins globulin NNS cord-009571-mygj2nd4 378 71 ; ; : cord-009571-mygj2nd4 378 72 3 3 LS cord-009571-mygj2nd4 378 73 ) ) -RRB- cord-009571-mygj2nd4 378 74 IgG IgG NNP cord-009571-mygj2nd4 378 75 rheumatoid rheumatoid NN cord-009571-mygj2nd4 378 76 factors factor NNS cord-009571-mygj2nd4 378 77 probably probably RB cord-009571-mygj2nd4 378 78 have have VBP cord-009571-mygj2nd4 378 79 different different JJ cord-009571-mygj2nd4 378 80 idiotypic idiotypic NNP cord-009571-mygj2nd4 378 81 antigens antigen NNS cord-009571-mygj2nd4 378 82 than than IN cord-009571-mygj2nd4 378 83 IgM IgM NNP cord-009571-mygj2nd4 378 84 rheumatoid rheumatoid NNP cord-009571-mygj2nd4 378 85 factors factor NNS cord-009571-mygj2nd4 378 86 and and CC cord-009571-mygj2nd4 378 87 may may MD cord-009571-mygj2nd4 378 88 therefore therefore RB cord-009571-mygj2nd4 378 89 have have VB cord-009571-mygj2nd4 378 90 different different JJ cord-009571-mygj2nd4 378 91 active active JJ cord-009571-mygj2nd4 378 92 sites site NNS cord-009571-mygj2nd4 378 93 and and CC cord-009571-mygj2nd4 378 94 antibody antibody NN cord-009571-mygj2nd4 378 95 specificities specificity NNS cord-009571-mygj2nd4 378 96 ; ; : cord-009571-mygj2nd4 378 97 4 4 LS cord-009571-mygj2nd4 378 98 ) ) -RRB- cord-009571-mygj2nd4 378 99 anti anti JJ cord-009571-mygj2nd4 378 100 - - JJ cord-009571-mygj2nd4 378 101 idiotypic idiotypic JJ cord-009571-mygj2nd4 378 102 antibodies antibody NNS cord-009571-mygj2nd4 378 103 may may MD cord-009571-mygj2nd4 378 104 be be VB cord-009571-mygj2nd4 378 105 useful useful JJ cord-009571-mygj2nd4 378 106 for for IN cord-009571-mygj2nd4 378 107 the the DT cord-009571-mygj2nd4 378 108 selective selective JJ cord-009571-mygj2nd4 378 109 suppression suppression NN cord-009571-mygj2nd4 378 110 of of IN cord-009571-mygj2nd4 378 111 anti anti JJ cord-009571-mygj2nd4 378 112 - - JJ cord-009571-mygj2nd4 378 113 yglobulin yglobulin JJ cord-009571-mygj2nd4 378 114 production production NN cord-009571-mygj2nd4 378 115 without without IN cord-009571-mygj2nd4 378 116 a a DT cord-009571-mygj2nd4 378 117 general general JJ cord-009571-mygj2nd4 378 118 depression depression NN cord-009571-mygj2nd4 378 119 of of IN cord-009571-mygj2nd4 378 120 immune immune JJ cord-009571-mygj2nd4 378 121 responsiveness responsiveness NN cord-009571-mygj2nd4 378 122 . . . cord-009571-mygj2nd4 379 1 Connective connective JJ cord-009571-mygj2nd4 379 2 tissue tissue NN cord-009571-mygj2nd4 379 3 activating activate VBG cord-009571-mygj2nd4 379 4 peptides peptide NNS cord-009571-mygj2nd4 379 5 from from IN cord-009571-mygj2nd4 379 6 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 379 7 ( ( -LRB- cord-009571-mygj2nd4 379 8 CTAP CTAP NNP cord-009571-mygj2nd4 379 9 - - HYPH cord-009571-mygj2nd4 379 10 I I NNP cord-009571-mygj2nd4 379 11 ) ) -RRB- cord-009571-mygj2nd4 379 12 and and CC cord-009571-mygj2nd4 379 13 platelets platelet NNS cord-009571-mygj2nd4 379 14 ( ( -LRB- cord-009571-mygj2nd4 379 15 CTAP-111 CTAP-111 NNP cord-009571-mygj2nd4 379 16 ) ) -RRB- cord-009571-mygj2nd4 379 17 are be VBP cord-009571-mygj2nd4 379 18 known know VBN cord-009571-mygj2nd4 379 19 to to TO cord-009571-mygj2nd4 379 20 stimulate stimulate VB cord-009571-mygj2nd4 379 21 glycosaminoglycan glycosaminoglycan JJ cord-009571-mygj2nd4 379 22 synthesis synthesis NN cord-009571-mygj2nd4 379 23 , , , cord-009571-mygj2nd4 379 24 glycolysis glycolysis NN cord-009571-mygj2nd4 379 25 , , , cord-009571-mygj2nd4 379 26 and and CC cord-009571-mygj2nd4 379 27 mitogenesis mitogenesis NN cord-009571-mygj2nd4 379 28 in in IN cord-009571-mygj2nd4 379 29 connective connective JJ cord-009571-mygj2nd4 379 30 tissue tissue NN cord-009571-mygj2nd4 379 31 cell cell NN cord-009571-mygj2nd4 379 32 cultures culture NNS cord-009571-mygj2nd4 379 33 . . . cord-009571-mygj2nd4 380 1 Direct direct JJ cord-009571-mygj2nd4 380 2 evidence evidence NN cord-009571-mygj2nd4 380 3 suggested suggest VBD cord-009571-mygj2nd4 380 4 that that IN cord-009571-mygj2nd4 380 5 increased increase VBN cord-009571-mygj2nd4 380 6 accumulation accumulation NN cord-009571-mygj2nd4 380 7 of of IN cord-009571-mygj2nd4 380 8 cyclic cyclic JJ cord-009571-mygj2nd4 380 9 AMP AMP NNP cord-009571-mygj2nd4 380 10 was be VBD cord-009571-mygj2nd4 380 11 involved involve VBN cord-009571-mygj2nd4 380 12 in in IN cord-009571-mygj2nd4 380 13 the the DT cord-009571-mygj2nd4 380 14 mechanism mechanism NN cord-009571-mygj2nd4 380 15 of of IN cord-009571-mygj2nd4 380 16 action action NN cord-009571-mygj2nd4 380 17 of of IN cord-009571-mygj2nd4 380 18 these these DT cord-009571-mygj2nd4 380 19 peptide peptide JJ cord-009571-mygj2nd4 380 20 agonists agonist NNS cord-009571-mygj2nd4 380 21 , , , cord-009571-mygj2nd4 380 22 and and CC cord-009571-mygj2nd4 380 23 increased increase VBD cord-009571-mygj2nd4 380 24 prostaglandin prostaglandin NN cord-009571-mygj2nd4 380 25 E e NN cord-009571-mygj2nd4 380 26 synthesis synthesis NN cord-009571-mygj2nd4 380 27 was be VBD cord-009571-mygj2nd4 380 28 postulated postulate VBN cord-009571-mygj2nd4 380 29 on on IN cord-009571-mygj2nd4 380 30 the the DT cord-009571-mygj2nd4 380 31 basis basis NN cord-009571-mygj2nd4 380 32 of of IN cord-009571-mygj2nd4 380 33 indirect indirect JJ cord-009571-mygj2nd4 380 34 evidence evidence NN cord-009571-mygj2nd4 380 35 . . . cord-009571-mygj2nd4 381 1 In in IN cord-009571-mygj2nd4 381 2 the the DT cord-009571-mygj2nd4 381 3 present present JJ cord-009571-mygj2nd4 381 4 experiments experiment NNS cord-009571-mygj2nd4 381 5 , , , cord-009571-mygj2nd4 381 6 CTAP CTAP NNP cord-009571-mygj2nd4 381 7 - - HYPH cord-009571-mygj2nd4 381 8 I I NNP cord-009571-mygj2nd4 381 9 and and CC cord-009571-mygj2nd4 381 10 -111 -111 NN cord-009571-mygj2nd4 381 11 were be VBD cord-009571-mygj2nd4 381 12 incubated incubate VBN cord-009571-mygj2nd4 381 13 with with IN cord-009571-mygj2nd4 381 14 human human JJ cord-009571-mygj2nd4 381 15 and and CC cord-009571-mygj2nd4 381 16 murine murine JJ cord-009571-mygj2nd4 381 17 cells cell NNS cord-009571-mygj2nd4 381 18 in in IN cord-009571-mygj2nd4 381 19 culture culture NN cord-009571-mygj2nd4 381 20 , , , cord-009571-mygj2nd4 381 21 and and CC cord-009571-mygj2nd4 381 22 prostaglandin prostaglandin NN cord-009571-mygj2nd4 381 23 E e NN cord-009571-mygj2nd4 381 24 was be VBD cord-009571-mygj2nd4 381 25 measured measure VBN cord-009571-mygj2nd4 381 26 by by IN cord-009571-mygj2nd4 381 27 radioimmunoassay radioimmunoassay JJ cord-009571-mygj2nd4 381 28 using use VBG cord-009571-mygj2nd4 381 29 antibody antibody NN cord-009571-mygj2nd4 381 30 directed direct VBN cord-009571-mygj2nd4 381 31 primarily primarily RB cord-009571-mygj2nd4 381 32 to to IN cord-009571-mygj2nd4 381 33 prostaglandin prostaglandin NN cord-009571-mygj2nd4 381 34 E e NN cord-009571-mygj2nd4 381 35 , , , cord-009571-mygj2nd4 381 36 . . . cord-009571-mygj2nd4 382 1 Both both DT cord-009571-mygj2nd4 382 2 CTAP CTAP NNP cord-009571-mygj2nd4 382 3 - - HYPH cord-009571-mygj2nd4 382 4 I -PRON- PRP cord-009571-mygj2nd4 382 5 and and CC cord-009571-mygj2nd4 382 6 -111 -111 VBP cord-009571-mygj2nd4 382 7 markedly markedly RB cord-009571-mygj2nd4 382 8 stimulated stimulate VBD cord-009571-mygj2nd4 382 9 the the DT cord-009571-mygj2nd4 382 10 elabo elabo NN cord-009571-mygj2nd4 382 11 - - HYPH cord-009571-mygj2nd4 382 12 ration ration NN cord-009571-mygj2nd4 382 13 of of IN cord-009571-mygj2nd4 382 14 prostaglandin prostaglandin NN cord-009571-mygj2nd4 382 15 E e NN cord-009571-mygj2nd4 382 16 , , , cord-009571-mygj2nd4 382 17 into into IN cord-009571-mygj2nd4 382 18 culture culture NN cord-009571-mygj2nd4 382 19 medium medium NN cord-009571-mygj2nd4 382 20 , , , cord-009571-mygj2nd4 382 21 the the DT cord-009571-mygj2nd4 382 22 earliest early JJS cord-009571-mygj2nd4 382 23 evidence evidence NN cord-009571-mygj2nd4 382 24 of of IN cord-009571-mygj2nd4 382 25 increased increase VBN cord-009571-mygj2nd4 382 26 synthesis synthesis NN cord-009571-mygj2nd4 382 27 occurring occur VBG cord-009571-mygj2nd4 382 28 at at IN cord-009571-mygj2nd4 382 29 4 4 CD cord-009571-mygj2nd4 382 30 hours hour NNS cord-009571-mygj2nd4 382 31 with with IN cord-009571-mygj2nd4 382 32 maximal maximal JJ cord-009571-mygj2nd4 382 33 concentration concentration NN cord-009571-mygj2nd4 382 34 found find VBN cord-009571-mygj2nd4 382 35 at at IN cord-009571-mygj2nd4 382 36 24 24 CD cord-009571-mygj2nd4 382 37 hours hour NNS cord-009571-mygj2nd4 382 38 . . . cord-009571-mygj2nd4 383 1 In in IN cord-009571-mygj2nd4 383 2 a a DT cord-009571-mygj2nd4 383 3 typical typical JJ cord-009571-mygj2nd4 383 4 experiment experiment NN cord-009571-mygj2nd4 383 5 , , , cord-009571-mygj2nd4 383 6 after after IN cord-009571-mygj2nd4 383 7 24 24 CD cord-009571-mygj2nd4 383 8 hours hour NNS cord-009571-mygj2nd4 383 9 incubation incubation NN cord-009571-mygj2nd4 383 10 , , , cord-009571-mygj2nd4 383 11 buffer buffer NN cord-009571-mygj2nd4 383 12 , , , cord-009571-mygj2nd4 383 13 CTAP CTAP NNP cord-009571-mygj2nd4 383 14 - - HYPH cord-009571-mygj2nd4 383 15 I I NNP cord-009571-mygj2nd4 383 16 and and CC cord-009571-mygj2nd4 383 17 CTAP CTAP NNP cord-009571-mygj2nd4 383 18 - - HYPH cord-009571-mygj2nd4 383 19 I11 I11 NNP cord-009571-mygj2nd4 383 20 treated treat VBD cord-009571-mygj2nd4 383 21 cells cell NNS cord-009571-mygj2nd4 383 22 produced produce VBN cord-009571-mygj2nd4 383 23 , , , cord-009571-mygj2nd4 383 24 respectively respectively RB cord-009571-mygj2nd4 383 25 , , , cord-009571-mygj2nd4 383 26 39 39 CD cord-009571-mygj2nd4 383 27 , , , cord-009571-mygj2nd4 383 28 1150 1150 CD cord-009571-mygj2nd4 383 29 , , , cord-009571-mygj2nd4 383 30 and and CC cord-009571-mygj2nd4 383 31 580 580 CD cord-009571-mygj2nd4 383 32 pg pg NN cord-009571-mygj2nd4 383 33 of of IN cord-009571-mygj2nd4 383 34 prostaglandin prostaglandin NN cord-009571-mygj2nd4 383 35 E,/1.5 E,/1.5 NNP cord-009571-mygj2nd4 384 1 X x NN cord-009571-mygj2nd4 384 2 1CP 1cp CD cord-009571-mygj2nd4 384 3 normal normal JJ cord-009571-mygj2nd4 384 4 human human JJ cord-009571-mygj2nd4 384 5 synovial synovial JJ cord-009571-mygj2nd4 384 6 cells cell NNS cord-009571-mygj2nd4 384 7 . . . cord-009571-mygj2nd4 385 1 Substantial substantial JJ cord-009571-mygj2nd4 385 2 residual residual JJ cord-009571-mygj2nd4 385 3 stimulation stimulation NN cord-009571-mygj2nd4 385 4 persisted persist VBD cord-009571-mygj2nd4 385 5 at at IN cord-009571-mygj2nd4 385 6 least least JJS cord-009571-mygj2nd4 385 7 through through IN cord-009571-mygj2nd4 385 8 48 48 CD cord-009571-mygj2nd4 385 9 hours hour NNS cord-009571-mygj2nd4 385 10 . . . cord-009571-mygj2nd4 386 1 The the DT cord-009571-mygj2nd4 386 2 lymphocyte lymphocyte NN cord-009571-mygj2nd4 386 3 factor factor NN cord-009571-mygj2nd4 386 4 ( ( -LRB- cord-009571-mygj2nd4 386 5 CTAP CTAP NNP cord-009571-mygj2nd4 386 6 - - HYPH cord-009571-mygj2nd4 386 7 I I NNP cord-009571-mygj2nd4 386 8 ) ) -RRB- cord-009571-mygj2nd4 386 9 appeared appear VBD cord-009571-mygj2nd4 386 10 to to TO cord-009571-mygj2nd4 386 11 be be VB cord-009571-mygj2nd4 386 12 more more RBR cord-009571-mygj2nd4 386 13 potent potent JJ cord-009571-mygj2nd4 386 14 than than IN cord-009571-mygj2nd4 386 15 CTAP CTAP NNP cord-009571-mygj2nd4 386 16 - - HYPH cord-009571-mygj2nd4 386 17 I11 I11 NNP cord-009571-mygj2nd4 386 18 in in IN cord-009571-mygj2nd4 386 19 stimulating stimulate VBG cord-009571-mygj2nd4 386 20 prostaglandin prostaglandin NN cord-009571-mygj2nd4 386 21 synthesis synthesis NN cord-009571-mygj2nd4 386 22 . . . cord-009571-mygj2nd4 387 1 Indomethacin Indomethacin NNP cord-009571-mygj2nd4 387 2 These these DT cord-009571-mygj2nd4 387 3 studies study NNS cord-009571-mygj2nd4 387 4 substantiate substantiate VBP cord-009571-mygj2nd4 387 5 the the DT cord-009571-mygj2nd4 387 6 postulated postulate VBN cord-009571-mygj2nd4 387 7 increase increase NN cord-009571-mygj2nd4 387 8 in in IN cord-009571-mygj2nd4 387 9 synthesis synthesis NN cord-009571-mygj2nd4 387 10 of of IN cord-009571-mygj2nd4 387 11 E E NNP cord-009571-mygj2nd4 387 12 series series NN cord-009571-mygj2nd4 387 13 prostaglandins prostaglandin NNS cord-009571-mygj2nd4 387 14 by by IN cord-009571-mygj2nd4 387 15 human human JJ cord-009571-mygj2nd4 387 16 connective connective JJ cord-009571-mygj2nd4 387 17 tissue tissue NN cord-009571-mygj2nd4 387 18 cells cell NNS cord-009571-mygj2nd4 387 19 on on IN cord-009571-mygj2nd4 387 20 exposure exposure NN cord-009571-mygj2nd4 387 21 of of IN cord-009571-mygj2nd4 387 22 CTAP CTAP NNP cord-009571-mygj2nd4 387 23 - - HYPH cord-009571-mygj2nd4 387 24 I i NN cord-009571-mygj2nd4 387 25 and and CC cord-009571-mygj2nd4 387 26 -111 -111 NN cord-009571-mygj2nd4 387 27 , , , cord-009571-mygj2nd4 387 28 and and CC cord-009571-mygj2nd4 387 29 clarify clarify VB cord-009571-mygj2nd4 387 30 the the DT cord-009571-mygj2nd4 387 31 mechanism mechanism NN cord-009571-mygj2nd4 387 32 of of IN cord-009571-mygj2nd4 387 33 action action NN cord-009571-mygj2nd4 387 34 of of IN cord-009571-mygj2nd4 387 35 these these DT cord-009571-mygj2nd4 387 36 agonists agonist NNS cord-009571-mygj2nd4 387 37 on on IN cord-009571-mygj2nd4 387 38 " " `` cord-009571-mygj2nd4 387 39 activated activate VBN cord-009571-mygj2nd4 387 40 " " '' cord-009571-mygj2nd4 387 41 target target NN cord-009571-mygj2nd4 387 42 cells cell NNS cord-009571-mygj2nd4 387 43 . . . cord-009571-mygj2nd4 388 1 The the DT cord-009571-mygj2nd4 388 2 importance importance NN cord-009571-mygj2nd4 388 3 of of IN cord-009571-mygj2nd4 388 4 elevated elevated JJ cord-009571-mygj2nd4 388 5 extracellular extracellular JJ cord-009571-mygj2nd4 388 6 concentrations concentration NNS cord-009571-mygj2nd4 388 7 of of IN cord-009571-mygj2nd4 388 8 prostaglandins prostaglandin NNS cord-009571-mygj2nd4 388 9 is be VBZ cord-009571-mygj2nd4 388 10 uncertain uncertain JJ cord-009571-mygj2nd4 388 11 , , , cord-009571-mygj2nd4 388 12 although although IN cord-009571-mygj2nd4 388 13 they -PRON- PRP cord-009571-mygj2nd4 388 14 may may MD cord-009571-mygj2nd4 388 15 potentiate potentiate VB cord-009571-mygj2nd4 388 16 the the DT cord-009571-mygj2nd4 388 17 actions action NNS cord-009571-mygj2nd4 388 18 of of IN cord-009571-mygj2nd4 388 19 CTAP CTAP NNP cord-009571-mygj2nd4 388 20 - - HYPH cord-009571-mygj2nd4 388 21 I -PRON- PRP cord-009571-mygj2nd4 388 22 and and CC cord-009571-mygj2nd4 388 23 -111 -111 NN cord-009571-mygj2nd4 388 24 . . . cord-009571-mygj2nd4 389 1 In in IN cord-009571-mygj2nd4 389 2 order order NN cord-009571-mygj2nd4 389 3 to to TO cord-009571-mygj2nd4 389 4 examine examine VB cord-009571-mygj2nd4 389 5 the the DT cord-009571-mygj2nd4 389 6 repair repair NN cord-009571-mygj2nd4 389 7 collagens collagen NNS cord-009571-mygj2nd4 389 8 produced produce VBN cord-009571-mygj2nd4 389 9 by by IN cord-009571-mygj2nd4 389 10 cells cell NNS cord-009571-mygj2nd4 389 11 present present JJ cord-009571-mygj2nd4 389 12 in in IN cord-009571-mygj2nd4 389 13 injured injure VBN cord-009571-mygj2nd4 389 14 cartilage cartilage NN cord-009571-mygj2nd4 389 15 , , , cord-009571-mygj2nd4 389 16 the the DT cord-009571-mygj2nd4 389 17 femoral femoral JJ cord-009571-mygj2nd4 389 18 articular articular JJ cord-009571-mygj2nd4 389 19 surfaces surface NNS cord-009571-mygj2nd4 389 20 of of IN cord-009571-mygj2nd4 389 21 three three CD cord-009571-mygj2nd4 389 22 groups group NNS cord-009571-mygj2nd4 389 23 of of IN cord-009571-mygj2nd4 389 24 New New NNP cord-009571-mygj2nd4 389 25 Zealand Zealand NNP cord-009571-mygj2nd4 389 26 white white JJ cord-009571-mygj2nd4 389 27 rabbits rabbit NNS cord-009571-mygj2nd4 389 28 were be VBD cord-009571-mygj2nd4 389 29 scarred scar VBN cord-009571-mygj2nd4 389 30 in in IN cord-009571-mygj2nd4 389 31 the the DT cord-009571-mygj2nd4 389 32 following following JJ cord-009571-mygj2nd4 389 33 manner manner NN cord-009571-mygj2nd4 389 34 : : : cord-009571-mygj2nd4 389 35 superficial superficial JJ cord-009571-mygj2nd4 389 36 and and CC cord-009571-mygj2nd4 389 37 deep deep JJ cord-009571-mygj2nd4 389 38 lacerations laceration NNS cord-009571-mygj2nd4 389 39 , , , cord-009571-mygj2nd4 389 40 and and CC cord-009571-mygj2nd4 389 41 drilled drill VBN cord-009571-mygj2nd4 389 42 holes hole NNS cord-009571-mygj2nd4 389 43 . . . cord-009571-mygj2nd4 390 1 Eight eight CD cord-009571-mygj2nd4 390 2 weeks week NNS cord-009571-mygj2nd4 390 3 after after IN cord-009571-mygj2nd4 390 4 surgery surgery NN cord-009571-mygj2nd4 390 5 the the DT cord-009571-mygj2nd4 390 6 rabbits rabbit NNS cord-009571-mygj2nd4 390 7 were be VBD cord-009571-mygj2nd4 390 8 sacrificed sacrifice VBN cord-009571-mygj2nd4 390 9 and and CC cord-009571-mygj2nd4 390 10 slices slice NNS cord-009571-mygj2nd4 390 11 of of IN cord-009571-mygj2nd4 390 12 injured injure VBN cord-009571-mygj2nd4 390 13 articular articular JJ cord-009571-mygj2nd4 390 14 cartilage cartilage NN cord-009571-mygj2nd4 390 15 harvested harvest VBN cord-009571-mygj2nd4 390 16 . . . cord-009571-mygj2nd4 391 1 The the DT cord-009571-mygj2nd4 391 2 types type NNS cord-009571-mygj2nd4 391 3 of of IN cord-009571-mygj2nd4 391 4 collagen collagen NN cord-009571-mygj2nd4 391 5 produced produce VBN cord-009571-mygj2nd4 391 6 at at IN cord-009571-mygj2nd4 391 7 the the DT cord-009571-mygj2nd4 391 8 site site NN cord-009571-mygj2nd4 391 9 of of IN cord-009571-mygj2nd4 391 10 these these DT cord-009571-mygj2nd4 391 11 lesions lesion NNS cord-009571-mygj2nd4 391 12 were be VBD cord-009571-mygj2nd4 391 13 identified identify VBN cord-009571-mygj2nd4 391 14 by by IN cord-009571-mygj2nd4 391 15 labeling label VBG cord-009571-mygj2nd4 391 16 the the DT cord-009571-mygj2nd4 391 17 recovered recover VBN cord-009571-mygj2nd4 391 18 specimens specimen NNS cord-009571-mygj2nd4 391 19 with with IN cord-009571-mygj2nd4 391 20 * * NFP cord-009571-mygj2nd4 391 21 H h NN cord-009571-mygj2nd4 391 22 proline proline NN cord-009571-mygj2nd4 391 23 and and CC cord-009571-mygj2nd4 391 24 characterized characterize VBN cord-009571-mygj2nd4 391 25 by by IN cord-009571-mygj2nd4 391 26 SDS SDS NNP cord-009571-mygj2nd4 391 27 gel gel NN cord-009571-mygj2nd4 391 28 electrophoresis electrophoresis NN cord-009571-mygj2nd4 391 29 , , , cord-009571-mygj2nd4 391 30 CMC CMC NNP cord-009571-mygj2nd4 391 31 chromatography chromatography NN cord-009571-mygj2nd4 391 32 , , , cord-009571-mygj2nd4 391 33 and and CC cord-009571-mygj2nd4 391 34 CNBr CNBr NNP cord-009571-mygj2nd4 391 35 peptide peptide NN cord-009571-mygj2nd4 391 36 analysis analysis NN cord-009571-mygj2nd4 391 37 . . . cord-009571-mygj2nd4 392 1 In in IN cord-009571-mygj2nd4 392 2 all all DT cord-009571-mygj2nd4 392 3 cases case NNS cord-009571-mygj2nd4 392 4 , , , cord-009571-mygj2nd4 392 5 tissue tissue NN cord-009571-mygj2nd4 392 6 - - HYPH cord-009571-mygj2nd4 392 7 specific specific JJ cord-009571-mygj2nd4 392 8 Type type NN cord-009571-mygj2nd4 392 9 I1 i1 NN cord-009571-mygj2nd4 392 10 ( ( -LRB- cord-009571-mygj2nd4 392 11 [ [ -LRB- cord-009571-mygj2nd4 392 12 aI ai NN cord-009571-mygj2nd4 392 13 ( ( -LRB- cord-009571-mygj2nd4 392 14 1 1 CD cord-009571-mygj2nd4 392 15 1)18 1)18 CD cord-009571-mygj2nd4 392 16 ) ) -RRB- cord-009571-mygj2nd4 393 1 cartilage cartilage NN cord-009571-mygj2nd4 393 2 collagen collagen NN cord-009571-mygj2nd4 393 3 was be VBD cord-009571-mygj2nd4 393 4 synthesized synthesize VBN cord-009571-mygj2nd4 393 5 . . . cord-009571-mygj2nd4 394 1 Histologic Histologic NNP cord-009571-mygj2nd4 394 2 examination examination NN cord-009571-mygj2nd4 394 3 revealed reveal VBD cord-009571-mygj2nd4 394 4 the the DT cord-009571-mygj2nd4 394 5 chondrocytes chondrocyte NNS cord-009571-mygj2nd4 394 6 bordering border VBG cord-009571-mygj2nd4 394 7 the the DT cord-009571-mygj2nd4 394 8 cartilage cartilage NN cord-009571-mygj2nd4 394 9 injured injure VBN cord-009571-mygj2nd4 394 10 by by IN cord-009571-mygj2nd4 394 11 deep deep JJ cord-009571-mygj2nd4 394 12 laceration laceration NN cord-009571-mygj2nd4 394 13 and and CC cord-009571-mygj2nd4 394 14 drill drill NN cord-009571-mygj2nd4 394 15 holes hole NNS cord-009571-mygj2nd4 394 16 responded respond VBN cord-009571-mygj2nd4 394 17 by by IN cord-009571-mygj2nd4 394 18 increased increase VBN cord-009571-mygj2nd4 394 19 cellular cellular JJ cord-009571-mygj2nd4 394 20 activity activity NN cord-009571-mygj2nd4 394 21 . . . cord-009571-mygj2nd4 395 1 Grossly grossly RB cord-009571-mygj2nd4 395 2 , , , cord-009571-mygj2nd4 395 3 the the DT cord-009571-mygj2nd4 395 4 drilled drill VBN cord-009571-mygj2nd4 395 5 holes hole NNS cord-009571-mygj2nd4 395 6 were be VBD cord-009571-mygj2nd4 395 7 completely completely RB cord-009571-mygj2nd4 395 8 filled fill VBN cord-009571-mygj2nd4 395 9 with with IN cord-009571-mygj2nd4 395 10 tissue tissue NN cord-009571-mygj2nd4 395 11 possessing possess VBG cord-009571-mygj2nd4 395 12 staining staining NN cord-009571-mygj2nd4 395 13 and and CC cord-009571-mygj2nd4 395 14 morphologic morphologic JJ cord-009571-mygj2nd4 395 15 characteristics characteristic NNS cord-009571-mygj2nd4 395 16 similar similar JJ cord-009571-mygj2nd4 395 17 to to IN cord-009571-mygj2nd4 395 18 that that DT cord-009571-mygj2nd4 395 19 of of IN cord-009571-mygj2nd4 395 20 hyaline hyaline JJ cord-009571-mygj2nd4 395 21 cartilage cartilage NN cord-009571-mygj2nd4 395 22 . . . cord-009571-mygj2nd4 396 1 These these DT cord-009571-mygj2nd4 396 2 data datum NNS cord-009571-mygj2nd4 396 3 strongly strongly RB cord-009571-mygj2nd4 396 4 suggest suggest VBP cord-009571-mygj2nd4 396 5 that that IN cord-009571-mygj2nd4 396 6 in in IN cord-009571-mygj2nd4 396 7 the the DT cord-009571-mygj2nd4 396 8 lacerative lacerative JJ cord-009571-mygj2nd4 396 9 type type NN cord-009571-mygj2nd4 396 10 of of IN cord-009571-mygj2nd4 396 11 injury injury NN cord-009571-mygj2nd4 396 12 , , , cord-009571-mygj2nd4 396 13 the the DT cord-009571-mygj2nd4 396 14 surrounding surround VBG cord-009571-mygj2nd4 396 15 tissue tissue NN cord-009571-mygj2nd4 396 16 will will MD cord-009571-mygj2nd4 396 17 produce produce VB cord-009571-mygj2nd4 396 18 enough enough JJ cord-009571-mygj2nd4 396 19 matrix matrix NN cord-009571-mygj2nd4 396 20 for for IN cord-009571-mygj2nd4 396 21 repair repair NN cord-009571-mygj2nd4 396 22 only only RB cord-009571-mygj2nd4 396 23 when when WRB cord-009571-mygj2nd4 396 24 the the DT cord-009571-mygj2nd4 396 25 subchondral subchondral JJ cord-009571-mygj2nd4 396 26 bone bone NN cord-009571-mygj2nd4 396 27 is be VBZ cord-009571-mygj2nd4 396 28 violated violate VBN cord-009571-mygj2nd4 396 29 . . . cord-009571-mygj2nd4 397 1 Both both DT cord-009571-mygj2nd4 397 2 repaired repair VBN cord-009571-mygj2nd4 397 3 and and CC cord-009571-mygj2nd4 397 4 normal normal JJ cord-009571-mygj2nd4 397 5 cartilage cartilage NN cord-009571-mygj2nd4 397 6 produce produce VBP cord-009571-mygj2nd4 397 7 tissue tissue NN cord-009571-mygj2nd4 397 8 - - HYPH cord-009571-mygj2nd4 397 9 specific specific JJ cord-009571-mygj2nd4 397 10 Type type NN cord-009571-mygj2nd4 397 11 I1 i1 NN cord-009571-mygj2nd4 397 12 collagen collagen NN cord-009571-mygj2nd4 397 13 . . . cord-009571-mygj2nd4 398 1 We -PRON- PRP cord-009571-mygj2nd4 398 2 recently recently RB cord-009571-mygj2nd4 398 3 demonstrated demonstrate VBD cord-009571-mygj2nd4 398 4 that that IN cord-009571-mygj2nd4 398 5 , , , cord-009571-mygj2nd4 398 6 from from IN cord-009571-mygj2nd4 398 7 birth birth NN cord-009571-mygj2nd4 398 8 on on IN cord-009571-mygj2nd4 398 9 , , , cord-009571-mygj2nd4 398 10 NZB nzb NN cord-009571-mygj2nd4 398 11 splenic splenic JJ cord-009571-mygj2nd4 398 12 B b NN cord-009571-mygj2nd4 398 13 cells cell NNS cord-009571-mygj2nd4 398 14 spontaneously spontaneously RB cord-009571-mygj2nd4 398 15 secrete secrete VBP cord-009571-mygj2nd4 398 16 40 40 CD cord-009571-mygj2nd4 398 17 to to TO cord-009571-mygj2nd4 398 18 100 100 CD cord-009571-mygj2nd4 398 19 times time NNS cord-009571-mygj2nd4 398 20 as as RB cord-009571-mygj2nd4 398 21 much much JJ cord-009571-mygj2nd4 398 22 pentameric pentameric NN cord-009571-mygj2nd4 398 23 IgM IgM NNP cord-009571-mygj2nd4 398 24 as as IN cord-009571-mygj2nd4 398 25 normal normal JJ cord-009571-mygj2nd4 398 26 B b NN cord-009571-mygj2nd4 398 27 cells cell NNS cord-009571-mygj2nd4 398 28 ( ( -LRB- cord-009571-mygj2nd4 398 29 J J NNP cord-009571-mygj2nd4 398 30 Immunol Immunol NNP cord-009571-mygj2nd4 398 31 119:1639 119:1639 NN cord-009571-mygj2nd4 398 32 ( ( -LRB- cord-009571-mygj2nd4 398 33 J J NNP cord-009571-mygj2nd4 398 34 Immunol Immunol NNP cord-009571-mygj2nd4 398 35 119 119 CD cord-009571-mygj2nd4 398 36 : : : cord-009571-mygj2nd4 398 37 , , , cord-009571-mygj2nd4 398 38 1977 1977 CD cord-009571-mygj2nd4 398 39 . . . cord-009571-mygj2nd4 399 1 Spleen spleen NN cord-009571-mygj2nd4 399 2 cells cell NNS cord-009571-mygj2nd4 399 3 from from IN cord-009571-mygj2nd4 399 4 6 6 CD cord-009571-mygj2nd4 399 5 to to TO cord-009571-mygj2nd4 399 6 10 10 CD cord-009571-mygj2nd4 399 7 week week NN cord-009571-mygj2nd4 399 8 old old JJ cord-009571-mygj2nd4 399 9 mice mouse NNS cord-009571-mygj2nd4 399 10 have have VBP cord-009571-mygj2nd4 399 11 been be VBN cord-009571-mygj2nd4 399 12 examined examine VBN cord-009571-mygj2nd4 399 13 in in IN cord-009571-mygj2nd4 399 14 further further JJ cord-009571-mygj2nd4 399 15 study study NN cord-009571-mygj2nd4 399 16 of of IN cord-009571-mygj2nd4 399 17 this this DT cord-009571-mygj2nd4 399 18 abnormality abnormality NN cord-009571-mygj2nd4 399 19 . . . cord-009571-mygj2nd4 400 1 NZB nzb NN cord-009571-mygj2nd4 400 2 spleen spleen NN cord-009571-mygj2nd4 400 3 suspensions suspension NNS cord-009571-mygj2nd4 400 4 contain contain VBP cord-009571-mygj2nd4 400 5 8 8 CD cord-009571-mygj2nd4 400 6 to to TO cord-009571-mygj2nd4 400 7 10 10 CD cord-009571-mygj2nd4 400 8 times time NNS cord-009571-mygj2nd4 400 9 as as IN cord-009571-mygj2nd4 400 10 many many JJ cord-009571-mygj2nd4 400 11 spontaneous spontaneous JJ cord-009571-mygj2nd4 400 12 plaques plaque NNS cord-009571-mygj2nd4 400 13 to to IN cord-009571-mygj2nd4 400 14 sheep sheep NN cord-009571-mygj2nd4 400 15 erythrocytes erythrocyte NNS cord-009571-mygj2nd4 400 16 and and CC cord-009571-mygj2nd4 400 17 to to IN cord-009571-mygj2nd4 400 18 TNP TNP NNP cord-009571-mygj2nd4 400 19 conjugated conjugated JJ cord-009571-mygj2nd4 400 20 sheep sheep NN cord-009571-mygj2nd4 400 21 erythrocytes erythrocyte VBZ cord-009571-mygj2nd4 400 22 as as IN cord-009571-mygj2nd4 400 23 normal normal JJ cord-009571-mygj2nd4 400 24 mice mouse NNS cord-009571-mygj2nd4 400 25 . . . cord-009571-mygj2nd4 401 1 There there EX cord-009571-mygj2nd4 401 2 is be VBZ cord-009571-mygj2nd4 401 3 a a DT cord-009571-mygj2nd4 401 4 similar similar JJ cord-009571-mygj2nd4 401 5 increase increase NN cord-009571-mygj2nd4 401 6 in in IN cord-009571-mygj2nd4 401 7 the the DT cord-009571-mygj2nd4 401 8 number number NN cord-009571-mygj2nd4 401 9 of of IN cord-009571-mygj2nd4 401 10 cells cell NNS cord-009571-mygj2nd4 401 11 secreting secrete VBG cord-009571-mygj2nd4 401 12 IgM IgM NNP cord-009571-mygj2nd4 401 13 as as IN cord-009571-mygj2nd4 401 14 detected detect VBN cord-009571-mygj2nd4 401 15 by by IN cord-009571-mygj2nd4 401 16 a a DT cord-009571-mygj2nd4 401 17 reverse reverse JJ cord-009571-mygj2nd4 401 18 plaque plaque NN cord-009571-mygj2nd4 401 19 assay assay NN cord-009571-mygj2nd4 401 20 . . . cord-009571-mygj2nd4 402 1 After after IN cord-009571-mygj2nd4 402 2 cold cold JJ cord-009571-mygj2nd4 402 3 ethanol ethanol NN cord-009571-mygj2nd4 402 4 - - HYPH cord-009571-mygj2nd4 402 5 acetic acetic JJ cord-009571-mygj2nd4 402 6 acid acid NN cord-009571-mygj2nd4 402 7 fixation fixation NN cord-009571-mygj2nd4 402 8 , , , cord-009571-mygj2nd4 402 9 it -PRON- PRP cord-009571-mygj2nd4 402 10 can can MD cord-009571-mygj2nd4 402 11 be be VB cord-009571-mygj2nd4 402 12 shown show VBN cord-009571-mygj2nd4 402 13 that that IN cord-009571-mygj2nd4 402 14 NZB nzb NN cord-009571-mygj2nd4 402 15 spleen spleen NN cord-009571-mygj2nd4 402 16 contains contain VBZ cord-009571-mygj2nd4 402 17 4 4 CD cord-009571-mygj2nd4 402 18 - - SYM cord-009571-mygj2nd4 402 19 696 696 CD cord-009571-mygj2nd4 402 20 cells cell NNS cord-009571-mygj2nd4 402 21 with with IN cord-009571-mygj2nd4 402 22 cytoplasmic cytoplasmic JJ cord-009571-mygj2nd4 402 23 IgM igm NN cord-009571-mygj2nd4 402 24 compared compare VBN cord-009571-mygj2nd4 402 25 to to IN cord-009571-mygj2nd4 402 26 0.2 0.2 CD cord-009571-mygj2nd4 402 27 - - SYM cord-009571-mygj2nd4 402 28 0.4 0.4 CD cord-009571-mygj2nd4 402 29 % % NN cord-009571-mygj2nd4 402 30 in in IN cord-009571-mygj2nd4 402 31 normals normal NNS cord-009571-mygj2nd4 402 32 . . . cord-009571-mygj2nd4 403 1 NZB nzb NN cord-009571-mygj2nd4 403 2 spleen spleen NN cord-009571-mygj2nd4 403 3 cells cell NNS cord-009571-mygj2nd4 403 4 were be VBD cord-009571-mygj2nd4 403 5 sorted sort VBN cord-009571-mygj2nd4 403 6 by by IN cord-009571-mygj2nd4 403 7 flow flow NN cord-009571-mygj2nd4 403 8 microfluorometry microfluorometry NN cord-009571-mygj2nd4 403 9 ( ( -LRB- cord-009571-mygj2nd4 403 10 FMF FMF NNP cord-009571-mygj2nd4 403 11 ) ) -RRB- cord-009571-mygj2nd4 403 12 into into IN cord-009571-mygj2nd4 403 13 surface surface NN cord-009571-mygj2nd4 404 1 Ig Ig NNP cord-009571-mygj2nd4 404 2 negative negative JJ cord-009571-mygj2nd4 404 3 cells cell NNS cord-009571-mygj2nd4 404 4 and and CC cord-009571-mygj2nd4 404 5 4 4 CD cord-009571-mygj2nd4 404 6 pools pool NNS cord-009571-mygj2nd4 404 7 with with IN cord-009571-mygj2nd4 404 8 increasing increase VBG cord-009571-mygj2nd4 404 9 levels level NNS cord-009571-mygj2nd4 404 10 of of IN cord-009571-mygj2nd4 404 11 surface surface NN cord-009571-mygj2nd4 404 12 IgM IgM NNP cord-009571-mygj2nd4 404 13 or or CC cord-009571-mygj2nd4 404 14 total total JJ cord-009571-mygj2nd4 404 15 Ig Ig NNP cord-009571-mygj2nd4 404 16 . . . cord-009571-mygj2nd4 405 1 The the DT cord-009571-mygj2nd4 405 2 surface surface NN cord-009571-mygj2nd4 405 3 Ig Ig NNP cord-009571-mygj2nd4 405 4 negative negative JJ cord-009571-mygj2nd4 405 5 fraction fraction NN cord-009571-mygj2nd4 405 6 produced produce VBD cord-009571-mygj2nd4 405 7 no no DT cord-009571-mygj2nd4 405 8 IgM igm NN cord-009571-mygj2nd4 405 9 but but CC cord-009571-mygj2nd4 405 10 the the DT cord-009571-mygj2nd4 405 11 positive positive JJ cord-009571-mygj2nd4 405 12 pools pool NNS cord-009571-mygj2nd4 406 1 each each DT cord-009571-mygj2nd4 406 2 had have VBD cord-009571-mygj2nd4 406 3 the the DT cord-009571-mygj2nd4 406 4 same same JJ cord-009571-mygj2nd4 406 5 level level NN cord-009571-mygj2nd4 406 6 of of IN cord-009571-mygj2nd4 406 7 IgM IgM NNP cord-009571-mygj2nd4 406 8 production production NN cord-009571-mygj2nd4 406 9 and and CC cord-009571-mygj2nd4 406 10 cytoplasmic cytoplasmic JJ cord-009571-mygj2nd4 406 11 staining staining NN cord-009571-mygj2nd4 406 12 . . . cord-009571-mygj2nd4 407 1 When when WRB cord-009571-mygj2nd4 407 2 sorted sort VBN cord-009571-mygj2nd4 407 3 into into IN cord-009571-mygj2nd4 407 4 4 4 CD cord-009571-mygj2nd4 407 5 pools pool NNS cord-009571-mygj2nd4 407 6 on on IN cord-009571-mygj2nd4 407 7 the the DT cord-009571-mygj2nd4 407 8 basis basis NN cord-009571-mygj2nd4 407 9 of of IN cord-009571-mygj2nd4 407 10 size size NN cord-009571-mygj2nd4 407 11 , , , cord-009571-mygj2nd4 407 12 however however RB cord-009571-mygj2nd4 407 13 , , , cord-009571-mygj2nd4 407 14 all all PDT cord-009571-mygj2nd4 407 15 the the DT cord-009571-mygj2nd4 407 16 IgM IgM NNP cord-009571-mygj2nd4 407 17 production production NN cord-009571-mygj2nd4 407 18 was be VBD cord-009571-mygj2nd4 407 19 found find VBN cord-009571-mygj2nd4 407 20 in in IN cord-009571-mygj2nd4 407 21 the the DT cord-009571-mygj2nd4 407 22 largest large JJS cord-009571-mygj2nd4 407 23 fraction fraction NN cord-009571-mygj2nd4 407 24 . . . cord-009571-mygj2nd4 408 1 NZB nzb NN cord-009571-mygj2nd4 408 2 spleen spleen NN cord-009571-mygj2nd4 408 3 suspensions suspension NNS cord-009571-mygj2nd4 408 4 contain contain VBP cord-009571-mygj2nd4 408 5 more more RBR cord-009571-mygj2nd4 408 6 large large JJ cord-009571-mygj2nd4 408 7 cells cell NNS cord-009571-mygj2nd4 408 8 than than IN cord-009571-mygj2nd4 408 9 normal normal JJ cord-009571-mygj2nd4 408 10 spleens spleen NNS cord-009571-mygj2nd4 408 11 by by IN cord-009571-mygj2nd4 408 12 Coulter Coulter NNP cord-009571-mygj2nd4 408 13 volume volume NN cord-009571-mygj2nd4 408 14 measurements measurement NNS cord-009571-mygj2nd4 408 15 and and CC cord-009571-mygj2nd4 408 16 FMF fmf NN cord-009571-mygj2nd4 408 17 reveals reveal VBZ cord-009571-mygj2nd4 408 18 more more RBR cord-009571-mygj2nd4 408 19 large large JJ cord-009571-mygj2nd4 408 20 surface surface NN cord-009571-mygj2nd4 408 21 Ig Ig NNP cord-009571-mygj2nd4 408 22 positive positive JJ cord-009571-mygj2nd4 408 23 cells cell NNS cord-009571-mygj2nd4 408 24 in in IN cord-009571-mygj2nd4 408 25 NZB nzb NN cord-009571-mygj2nd4 408 26 than than IN cord-009571-mygj2nd4 408 27 normal normal JJ cord-009571-mygj2nd4 408 28 spleens spleen NNS cord-009571-mygj2nd4 408 29 . . . cord-009571-mygj2nd4 409 1 When when WRB cord-009571-mygj2nd4 409 2 surface surface NN cord-009571-mygj2nd4 409 3 Ig Ig NNP cord-009571-mygj2nd4 409 4 was be VBD cord-009571-mygj2nd4 409 5 enzymatically enzymatically RB cord-009571-mygj2nd4 409 6 removed remove VBN cord-009571-mygj2nd4 409 7 before before IN cord-009571-mygj2nd4 409 8 fixation fixation NN cord-009571-mygj2nd4 409 9 , , , cord-009571-mygj2nd4 409 10 it -PRON- PRP cord-009571-mygj2nd4 409 11 was be VBD cord-009571-mygj2nd4 409 12 found find VBN cord-009571-mygj2nd4 409 13 that that IN cord-009571-mygj2nd4 409 14 the the DT cord-009571-mygj2nd4 409 15 NZB nzb NN cord-009571-mygj2nd4 409 16 cells cell NNS cord-009571-mygj2nd4 409 17 with with IN cord-009571-mygj2nd4 409 18 cytoplasmic cytoplasmic JJ cord-009571-mygj2nd4 409 19 Ig Ig NNPS cord-009571-mygj2nd4 409 20 were be VBD cord-009571-mygj2nd4 409 21 4 4 CD cord-009571-mygj2nd4 409 22 to to IN cord-009571-mygj2nd4 409 23 S S NNP cord-009571-mygj2nd4 409 24 times time NNS cord-009571-mygj2nd4 409 25 brighter bright JJR cord-009571-mygj2nd4 409 26 than than IN cord-009571-mygj2nd4 409 27 those those DT cord-009571-mygj2nd4 409 28 from from IN cord-009571-mygj2nd4 409 29 normal normal JJ cord-009571-mygj2nd4 409 30 mice mouse NNS cord-009571-mygj2nd4 409 31 . . . cord-009571-mygj2nd4 410 1 Thus thus RB cord-009571-mygj2nd4 410 2 NZB nzb NN cord-009571-mygj2nd4 410 3 spleen spleen NN cord-009571-mygj2nd4 410 4 contains contain VBZ cord-009571-mygj2nd4 410 5 approximately approximately RB cord-009571-mygj2nd4 410 6 10 10 CD cord-009571-mygj2nd4 410 7 times time NNS cord-009571-mygj2nd4 410 8 as as IN cord-009571-mygj2nd4 410 9 many many JJ cord-009571-mygj2nd4 410 10 cells cell NNS cord-009571-mygj2nd4 410 11 which which WDT cord-009571-mygj2nd4 410 12 synthesize synthesize VBP cord-009571-mygj2nd4 410 13 and and CC cord-009571-mygj2nd4 410 14 secrete secrete JJ cord-009571-mygj2nd4 410 15 IgM igm NN cord-009571-mygj2nd4 410 16 as as IN cord-009571-mygj2nd4 410 17 normal normal JJ cord-009571-mygj2nd4 410 18 mice mouse NNS cord-009571-mygj2nd4 410 19 . . . cord-009571-mygj2nd4 411 1 Each each DT cord-009571-mygj2nd4 411 2 such such JJ cord-009571-mygj2nd4 411 3 NZB nzb NN cord-009571-mygj2nd4 411 4 cell cell NN cord-009571-mygj2nd4 411 5 appears appear VBZ cord-009571-mygj2nd4 411 6 to to TO cord-009571-mygj2nd4 411 7 contain contain VB cord-009571-mygj2nd4 411 8 and and CC cord-009571-mygj2nd4 411 9 presumably presumably RB cord-009571-mygj2nd4 411 10 secrete secrete VB cord-009571-mygj2nd4 411 11 about about RB cord-009571-mygj2nd4 411 12 5 5 CD cord-009571-mygj2nd4 411 13 times time NNS cord-009571-mygj2nd4 411 14 as as RB cord-009571-mygj2nd4 411 15 much much JJ cord-009571-mygj2nd4 411 16 IgM IgM NNP cord-009571-mygj2nd4 411 17 as as IN cord-009571-mygj2nd4 411 18 do do VBP cord-009571-mygj2nd4 411 19 cytoplasmic cytoplasmic JJ cord-009571-mygj2nd4 411 20 Ig Ig NNP cord-009571-mygj2nd4 411 21 positive positive JJ cord-009571-mygj2nd4 411 22 cells cell NNS cord-009571-mygj2nd4 411 23 in in IN cord-009571-mygj2nd4 411 24 normal normal JJ cord-009571-mygj2nd4 411 25 mouse mouse NN cord-009571-mygj2nd4 411 26 spleen spleen NNS cord-009571-mygj2nd4 411 27 . . . cord-009571-mygj2nd4 412 1 Because because IN cord-009571-mygj2nd4 412 2 NZB nzb NN cord-009571-mygj2nd4 412 3 mice mouse NNS cord-009571-mygj2nd4 412 4 spontaneously spontaneously RB cord-009571-mygj2nd4 412 5 produce produce VBP cord-009571-mygj2nd4 412 6 antibody antibody NN cord-009571-mygj2nd4 412 7 to to IN cord-009571-mygj2nd4 412 8 thymocytes thymocyte NNS cord-009571-mygj2nd4 412 9 , , , cord-009571-mygj2nd4 412 10 we -PRON- PRP cord-009571-mygj2nd4 412 11 utilized utilize VBD cord-009571-mygj2nd4 412 12 FMF FMF NNP cord-009571-mygj2nd4 412 13 at at IN cord-009571-mygj2nd4 412 14 high high JJ cord-009571-mygj2nd4 412 15 gain gain NN cord-009571-mygj2nd4 412 16 to to TO cord-009571-mygj2nd4 412 17 search search VB cord-009571-mygj2nd4 412 18 for for IN cord-009571-mygj2nd4 412 19 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 412 20 on on IN cord-009571-mygj2nd4 412 21 peripheral peripheral JJ cord-009571-mygj2nd4 412 22 T T NNP cord-009571-mygj2nd4 412 23 cells cell NNS cord-009571-mygj2nd4 412 24 . . . cord-009571-mygj2nd4 413 1 None none NN cord-009571-mygj2nd4 413 2 could could MD cord-009571-mygj2nd4 413 3 be be VB cord-009571-mygj2nd4 413 4 demonstrated demonstrate VBN cord-009571-mygj2nd4 413 5 . . . cord-009571-mygj2nd4 414 1 After after IN cord-009571-mygj2nd4 414 2 fixation fixation NN cord-009571-mygj2nd4 414 3 , , , cord-009571-mygj2nd4 414 4 however however RB cord-009571-mygj2nd4 414 5 , , , cord-009571-mygj2nd4 414 6 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 414 7 was be VBD cord-009571-mygj2nd4 414 8 readily readily RB cord-009571-mygj2nd4 414 9 detected detect VBN cord-009571-mygj2nd4 414 10 in in IN cord-009571-mygj2nd4 414 11 NZB nzb NN cord-009571-mygj2nd4 414 12 splenic splenic JJ cord-009571-mygj2nd4 414 13 T t NN cord-009571-mygj2nd4 414 14 cells cell NNS cord-009571-mygj2nd4 414 15 . . . cord-009571-mygj2nd4 415 1 Whether whether IN cord-009571-mygj2nd4 415 2 this this DT cord-009571-mygj2nd4 415 3 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 415 4 is be VBZ cord-009571-mygj2nd4 415 5 passively passively RB cord-009571-mygj2nd4 415 6 acquired acquire VBN cord-009571-mygj2nd4 415 7 and and CC cord-009571-mygj2nd4 415 8 rapidly rapidly RB cord-009571-mygj2nd4 415 9 pinocytosed pinocytosed JJ cord-009571-mygj2nd4 415 10 and and CC cord-009571-mygj2nd4 415 11 thus thus RB cord-009571-mygj2nd4 415 12 not not RB cord-009571-mygj2nd4 415 13 available available JJ cord-009571-mygj2nd4 415 14 for for IN cord-009571-mygj2nd4 415 15 staining stain VBG cord-009571-mygj2nd4 415 16 on on IN cord-009571-mygj2nd4 415 17 the the DT cord-009571-mygj2nd4 415 18 cell cell NN cord-009571-mygj2nd4 415 19 surface surface NN cord-009571-mygj2nd4 415 20 or or CC cord-009571-mygj2nd4 415 21 endogenously endogenously RB cord-009571-mygj2nd4 415 22 synthesized synthesize VBN cord-009571-mygj2nd4 415 23 by by IN cord-009571-mygj2nd4 415 24 the the DT cord-009571-mygj2nd4 415 25 T T NNP cord-009571-mygj2nd4 415 26 cell cell NN cord-009571-mygj2nd4 415 27 is be VBZ cord-009571-mygj2nd4 415 28 under under IN cord-009571-mygj2nd4 415 29 investigation investigation NN cord-009571-mygj2nd4 415 30 . . . cord-009571-mygj2nd4 416 1 In in IN cord-009571-mygj2nd4 416 2 an an DT cord-009571-mygj2nd4 416 3 effort effort NN cord-009571-mygj2nd4 416 4 to to TO cord-009571-mygj2nd4 416 5 define define VB cord-009571-mygj2nd4 416 6 the the DT cord-009571-mygj2nd4 416 7 cellular cellular JJ cord-009571-mygj2nd4 416 8 basis basis NN cord-009571-mygj2nd4 416 9 of of IN cord-009571-mygj2nd4 416 10 abnormalities abnormality NNS cord-009571-mygj2nd4 416 11 of of IN cord-009571-mygj2nd4 416 12 polyclonal polyclonal JJ cord-009571-mygj2nd4 416 13 B b NN cord-009571-mygj2nd4 416 14 cell cell NN cord-009571-mygj2nd4 416 15 activation activation NN cord-009571-mygj2nd4 416 16 previously previously RB cord-009571-mygj2nd4 416 17 noted note VBN cord-009571-mygj2nd4 416 18 in in IN cord-009571-mygj2nd4 416 19 NZB nzb NN cord-009571-mygj2nd4 416 20 mice mouse NNS cord-009571-mygj2nd4 416 21 , , , cord-009571-mygj2nd4 416 22 the the DT cord-009571-mygj2nd4 416 23 surface surface NN cord-009571-mygj2nd4 416 24 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 416 25 ( ( -LRB- cord-009571-mygj2nd4 416 26 sIg sIg NNP cord-009571-mygj2nd4 416 27 ) ) -RRB- cord-009571-mygj2nd4 416 28 isotypes isotype NNS cord-009571-mygj2nd4 416 29 of of IN cord-009571-mygj2nd4 416 30 spleen spleen NN cord-009571-mygj2nd4 416 31 cells cell NNS cord-009571-mygj2nd4 416 32 from from IN cord-009571-mygj2nd4 416 33 young young JJ cord-009571-mygj2nd4 416 34 and and CC cord-009571-mygj2nd4 416 35 old old JJ cord-009571-mygj2nd4 416 36 NZB nzb NN cord-009571-mygj2nd4 416 37 mice mouse NNS cord-009571-mygj2nd4 416 38 were be VBD cord-009571-mygj2nd4 416 39 examined examine VBN cord-009571-mygj2nd4 416 40 . . . cord-009571-mygj2nd4 417 1 After after IN cord-009571-mygj2nd4 417 2 lactoperoxidase lactoperoxidase NN cord-009571-mygj2nd4 417 3 - - HYPH cord-009571-mygj2nd4 417 4 catalyzed catalyze VBN cord-009571-mygj2nd4 417 5 radioiodination radioiodination NN cord-009571-mygj2nd4 417 6 , , , cord-009571-mygj2nd4 417 7 cells cell NNS cord-009571-mygj2nd4 417 8 were be VBD cord-009571-mygj2nd4 417 9 lysed lyse VBN cord-009571-mygj2nd4 417 10 , , , cord-009571-mygj2nd4 417 11 the the DT cord-009571-mygj2nd4 417 12 immunoglobulins immunoglobulin NNS cord-009571-mygj2nd4 417 13 bound bind VBN cord-009571-mygj2nd4 417 14 to to TO cord-009571-mygj2nd4 417 15 rabbit rabbit VB cord-009571-mygj2nd4 417 16 anti anti JJ cord-009571-mygj2nd4 417 17 - - JJ cord-009571-mygj2nd4 417 18 mouse mouse JJ cord-009571-mygj2nd4 417 19 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 417 20 and and CC cord-009571-mygj2nd4 417 21 the the DT cord-009571-mygj2nd4 417 22 immune immune JJ cord-009571-mygj2nd4 417 23 complexes complex NNS cord-009571-mygj2nd4 417 24 absorbed absorb VBN cord-009571-mygj2nd4 417 25 to to IN cord-009571-mygj2nd4 417 26 S S NNP cord-009571-mygj2nd4 417 27 aureus aureus NN cord-009571-mygj2nd4 417 28 . . . cord-009571-mygj2nd4 418 1 The the DT cord-009571-mygj2nd4 418 2 complexes complex NNS cord-009571-mygj2nd4 418 3 were be VBD cord-009571-mygj2nd4 418 4 solubilized solubilize VBN cord-009571-mygj2nd4 418 5 and and CC cord-009571-mygj2nd4 418 6 the the DT cord-009571-mygj2nd4 418 7 cell cell NN cord-009571-mygj2nd4 418 8 surface surface NN cord-009571-mygj2nd4 418 9 immunoglobulins immunoglobulin NNS cord-009571-mygj2nd4 418 10 analyzed analyze VBN cord-009571-mygj2nd4 418 11 by by IN cord-009571-mygj2nd4 418 12 sodium sodium NN cord-009571-mygj2nd4 418 13 dodecyl dodecyl NNP cord-009571-mygj2nd4 418 14 sulfate sulfate NNP cord-009571-mygj2nd4 418 15 ( ( -LRB- cord-009571-mygj2nd4 418 16 SDS SDS NNP cord-009571-mygj2nd4 418 17 ) ) -RRB- cord-009571-mygj2nd4 418 18 polyacrylamide polyacrylamide NN cord-009571-mygj2nd4 418 19 gel gel NN cord-009571-mygj2nd4 418 20 electrophoresis electrophoresis NN cord-009571-mygj2nd4 418 21 . . . cord-009571-mygj2nd4 419 1 Cell cell NN cord-009571-mygj2nd4 419 2 surface surface NN cord-009571-mygj2nd4 419 3 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 419 4 isotypes isotype NNS cord-009571-mygj2nd4 419 5 were be VBD cord-009571-mygj2nd4 419 6 also also RB cord-009571-mygj2nd4 419 7 analyzed analyze VBN cord-009571-mygj2nd4 419 8 by by IN cord-009571-mygj2nd4 419 9 staining stain VBG cord-009571-mygj2nd4 419 10 spleen spleen NN cord-009571-mygj2nd4 419 11 cells cell NNS cord-009571-mygj2nd4 419 12 with with IN cord-009571-mygj2nd4 419 13 fluorescein fluorescein NN cord-009571-mygj2nd4 419 14 - - HYPH cord-009571-mygj2nd4 419 15 conjugated conjugate VBN cord-009571-mygj2nd4 419 16 rabbit rabbit NN cord-009571-mygj2nd4 419 17 anti anti NN cord-009571-mygj2nd4 419 18 - - NN cord-009571-mygj2nd4 419 19 p p NNP cord-009571-mygj2nd4 419 20 , , , cord-009571-mygj2nd4 419 21 anti-6 anti-6 NNP cord-009571-mygj2nd4 419 22 , , , cord-009571-mygj2nd4 419 23 and and CC cord-009571-mygj2nd4 419 24 anti anti JJ cord-009571-mygj2nd4 419 25 - - JJ cord-009571-mygj2nd4 419 26 Ig ig JJ cord-009571-mygj2nd4 419 27 sera sera NNP cord-009571-mygj2nd4 419 28 and and CC cord-009571-mygj2nd4 419 29 examining examine VBG cord-009571-mygj2nd4 419 30 stained stain VBN cord-009571-mygj2nd4 419 31 cells cell NNS cord-009571-mygj2nd4 419 32 by by IN cord-009571-mygj2nd4 419 33 fluorescence fluorescence NN cord-009571-mygj2nd4 419 34 microscopy microscopy NNS cord-009571-mygj2nd4 419 35 or or CC cord-009571-mygj2nd4 419 36 by by IN cord-009571-mygj2nd4 419 37 automated automate VBN cord-009571-mygj2nd4 419 38 cytofluorometry cytofluorometry NN cord-009571-mygj2nd4 419 39 on on IN cord-009571-mygj2nd4 419 40 a a DT cord-009571-mygj2nd4 419 41 Becton Becton NNP cord-009571-mygj2nd4 419 42 - - HYPH cord-009571-mygj2nd4 419 43 Dickinson Dickinson NNP cord-009571-mygj2nd4 419 44 FACS-111 FACS-111 NNP cord-009571-mygj2nd4 419 45 cell cell NN cord-009571-mygj2nd4 419 46 sorter sorter NN cord-009571-mygj2nd4 419 47 . . . cord-009571-mygj2nd4 420 1 Spleen spleen NN cord-009571-mygj2nd4 420 2 cells cell NNS cord-009571-mygj2nd4 420 3 from from IN cord-009571-mygj2nd4 420 4 both both DT cord-009571-mygj2nd4 420 5 young young JJ cord-009571-mygj2nd4 420 6 ( ( -LRB- cord-009571-mygj2nd4 420 7 6 6 CD cord-009571-mygj2nd4 420 8 weeks week NNS cord-009571-mygj2nd4 420 9 old old JJ cord-009571-mygj2nd4 420 10 ) ) -RRB- cord-009571-mygj2nd4 420 11 and and CC cord-009571-mygj2nd4 420 12 old old JJ cord-009571-mygj2nd4 420 13 ( ( -LRB- cord-009571-mygj2nd4 420 14 one one CD cord-009571-mygj2nd4 420 15 year year NN cord-009571-mygj2nd4 420 16 old old JJ cord-009571-mygj2nd4 420 17 ) ) -RRB- cord-009571-mygj2nd4 420 18 NZB nzb NN cord-009571-mygj2nd4 420 19 mice mouse NNS cord-009571-mygj2nd4 420 20 were be VBD cord-009571-mygj2nd4 420 21 found find VBN cord-009571-mygj2nd4 420 22 to to TO cord-009571-mygj2nd4 420 23 have have VB cord-009571-mygj2nd4 420 24 markedly markedly RB cord-009571-mygj2nd4 420 25 increased increase VBN cord-009571-mygj2nd4 420 26 ratios ratio NNS cord-009571-mygj2nd4 420 27 of of IN cord-009571-mygj2nd4 420 28 cell cell NN cord-009571-mygj2nd4 420 29 surface surface NN cord-009571-mygj2nd4 420 30 IgM IgM NNP cord-009571-mygj2nd4 420 31 / / SYM cord-009571-mygj2nd4 420 32 IgD IgD NNP cord-009571-mygj2nd4 420 33 compared compare VBN cord-009571-mygj2nd4 420 34 to to IN cord-009571-mygj2nd4 420 35 cells cell NNS cord-009571-mygj2nd4 420 36 from from IN cord-009571-mygj2nd4 420 37 BALB BALB NNP cord-009571-mygj2nd4 420 38 / / SYM cord-009571-mygj2nd4 420 39 c c NNP cord-009571-mygj2nd4 420 40 control control NN cord-009571-mygj2nd4 420 41 mice mouse NNS cord-009571-mygj2nd4 420 42 . . . cord-009571-mygj2nd4 421 1 The the DT cord-009571-mygj2nd4 421 2 altered altered JJ cord-009571-mygj2nd4 421 3 ratio ratio NN cord-009571-mygj2nd4 421 4 of of IN cord-009571-mygj2nd4 421 5 sIg sig JJ cord-009571-mygj2nd4 421 6 isotypes isotypes NNP cord-009571-mygj2nd4 421 7 was be VBD cord-009571-mygj2nd4 421 8 not not RB cord-009571-mygj2nd4 421 9 a a DT cord-009571-mygj2nd4 421 10 consequence consequence NN cord-009571-mygj2nd4 421 11 of of IN cord-009571-mygj2nd4 421 12 increased increase VBN cord-009571-mygj2nd4 421 13 proteolytic proteolytic JJ cord-009571-mygj2nd4 421 14 activity activity NN cord-009571-mygj2nd4 421 15 present present NN cord-009571-mygj2nd4 421 16 in in IN cord-009571-mygj2nd4 421 17 NZB nzb NN cord-009571-mygj2nd4 421 18 cell cell NN cord-009571-mygj2nd4 421 19 suspensions suspension NNS cord-009571-mygj2nd4 421 20 since since IN cord-009571-mygj2nd4 421 21 the the DT cord-009571-mygj2nd4 421 22 addition addition NN cord-009571-mygj2nd4 421 23 of of IN cord-009571-mygj2nd4 421 24 NZB nzb NN cord-009571-mygj2nd4 421 25 cells cell NNS cord-009571-mygj2nd4 421 26 to to IN cord-009571-mygj2nd4 421 27 iodinated iodinate VBN cord-009571-mygj2nd4 421 28 BALB BALB NNP cord-009571-mygj2nd4 421 29 / / SYM cord-009571-mygj2nd4 421 30 c c NN cord-009571-mygj2nd4 421 31 cells cell NNS cord-009571-mygj2nd4 421 32 did do VBD cord-009571-mygj2nd4 421 33 not not RB cord-009571-mygj2nd4 421 34 alter alter VB cord-009571-mygj2nd4 421 35 the the DT cord-009571-mygj2nd4 421 36 BALB BALB NNP cord-009571-mygj2nd4 421 37 / / SYM cord-009571-mygj2nd4 421 38 c c NN cord-009571-mygj2nd4 421 39 ratio ratio NN cord-009571-mygj2nd4 421 40 of of IN cord-009571-mygj2nd4 421 41 sIgM/ sigm/ CD cord-009571-mygj2nd4 422 1 sIgD. sIgD. '' cord-009571-mygj2nd4 423 1 It -PRON- PRP cord-009571-mygj2nd4 423 2 was be VBD cord-009571-mygj2nd4 423 3 not not RB cord-009571-mygj2nd4 423 4 due due JJ cord-009571-mygj2nd4 423 5 to to IN cord-009571-mygj2nd4 423 6 the the DT cord-009571-mygj2nd4 423 7 presence presence NN cord-009571-mygj2nd4 423 8 of of IN cord-009571-mygj2nd4 423 9 cytophilic cytophilic NNP cord-009571-mygj2nd4 423 10 antibody antibody NNP cord-009571-mygj2nd4 423 11 or or CC cord-009571-mygj2nd4 423 12 autoanti autoanti NNS cord-009571-mygj2nd4 423 13 - - HYPH cord-009571-mygj2nd4 423 14 body body NN cord-009571-mygj2nd4 423 15 since since IN cord-009571-mygj2nd4 423 16 the the DT cord-009571-mygj2nd4 423 17 sIgM sigm NN cord-009571-mygj2nd4 423 18 was be VBD cord-009571-mygj2nd4 423 19 found find VBN cord-009571-mygj2nd4 423 20 to to TO cord-009571-mygj2nd4 423 21 have have VB cord-009571-mygj2nd4 423 22 a a DT cord-009571-mygj2nd4 423 23 sedimentation sedimentation NN cord-009571-mygj2nd4 423 24 coefficient coefficient NN cord-009571-mygj2nd4 423 25 of of IN cord-009571-mygj2nd4 423 26 8s 8s NNPS cord-009571-mygj2nd4 423 27 and and CC cord-009571-mygj2nd4 423 28 was be VBD cord-009571-mygj2nd4 423 29 thus thus RB cord-009571-mygj2nd4 423 30 not not RB cord-009571-mygj2nd4 423 31 of of IN cord-009571-mygj2nd4 423 32 serum serum NN cord-009571-mygj2nd4 423 33 origin origin NN cord-009571-mygj2nd4 423 34 . . . cord-009571-mygj2nd4 424 1 When when WRB cord-009571-mygj2nd4 424 2 examined examine VBN cord-009571-mygj2nd4 424 3 by by IN cord-009571-mygj2nd4 424 4 fluorescence fluorescence NN cord-009571-mygj2nd4 424 5 microscopy microscopy NNS cord-009571-mygj2nd4 424 6 or or CC cord-009571-mygj2nd4 424 7 by by IN cord-009571-mygj2nd4 424 8 cytofluorometry cytofluorometry NNP cord-009571-mygj2nd4 424 9 , , , cord-009571-mygj2nd4 424 10 NZB nzb NN cord-009571-mygj2nd4 424 11 spleen spleen NN cord-009571-mygj2nd4 424 12 cells cell NNS cord-009571-mygj2nd4 424 13 were be VBD cord-009571-mygj2nd4 424 14 found find VBN cord-009571-mygj2nd4 424 15 to to TO cord-009571-mygj2nd4 424 16 have have VB cord-009571-mygj2nd4 424 17 normal normal JJ cord-009571-mygj2nd4 424 18 numbers number NNS cord-009571-mygj2nd4 424 19 of of IN cord-009571-mygj2nd4 424 20 sIgM+ sIgM+ NNP cord-009571-mygj2nd4 424 21 and and CC cord-009571-mygj2nd4 424 22 sIgDf sigdf CC cord-009571-mygj2nd4 424 23 cells cell NNS cord-009571-mygj2nd4 424 24 , , , cord-009571-mygj2nd4 424 25 indicating indicate VBG cord-009571-mygj2nd4 424 26 that that IN cord-009571-mygj2nd4 424 27 the the DT cord-009571-mygj2nd4 424 28 altered alter VBN cord-009571-mygj2nd4 424 29 sIgM sigm NN cord-009571-mygj2nd4 424 30 / / SYM cord-009571-mygj2nd4 424 31 sIgD sigd NN cord-009571-mygj2nd4 424 32 ratio ratio NN cord-009571-mygj2nd4 424 33 observed observe VBN cord-009571-mygj2nd4 424 34 in in IN cord-009571-mygj2nd4 424 35 the the DT cord-009571-mygj2nd4 424 36 radioiodination radioiodination NN cord-009571-mygj2nd4 424 37 experiments experiment NNS cord-009571-mygj2nd4 424 38 was be VBD cord-009571-mygj2nd4 424 39 due due JJ cord-009571-mygj2nd4 424 40 to to IN cord-009571-mygj2nd4 424 41 abnormal abnormal JJ cord-009571-mygj2nd4 424 42 densities density NNS cord-009571-mygj2nd4 424 43 of of IN cord-009571-mygj2nd4 424 44 these these DT cord-009571-mygj2nd4 424 45 isotypes isotype NNS cord-009571-mygj2nd4 424 46 on on IN cord-009571-mygj2nd4 424 47 B B NNP cord-009571-mygj2nd4 424 48 cells cell NNS cord-009571-mygj2nd4 424 49 rather rather RB cord-009571-mygj2nd4 424 50 than than IN cord-009571-mygj2nd4 424 51 to to IN cord-009571-mygj2nd4 424 52 the the DT cord-009571-mygj2nd4 424 53 absence absence NN cord-009571-mygj2nd4 424 54 of of IN cord-009571-mygj2nd4 424 55 an an DT cord-009571-mygj2nd4 424 56 IgD igd NN cord-009571-mygj2nd4 424 57 - - HYPH cord-009571-mygj2nd4 424 58 bearing bear VBG cord-009571-mygj2nd4 424 59 B b NN cord-009571-mygj2nd4 424 60 cell cell NN cord-009571-mygj2nd4 424 61 subset subset JJ cord-009571-mygj2nd4 424 62 . . . cord-009571-mygj2nd4 425 1 The the DT cord-009571-mygj2nd4 425 2 increased increase VBN cord-009571-mygj2nd4 425 3 sIgM sigm NN cord-009571-mygj2nd4 425 4 / / SYM cord-009571-mygj2nd4 425 5 sIgD sigd NN cord-009571-mygj2nd4 425 6 ratio ratio NN cord-009571-mygj2nd4 425 7 may may MD cord-009571-mygj2nd4 425 8 be be VB cord-009571-mygj2nd4 425 9 a a DT cord-009571-mygj2nd4 425 10 consequence consequence NN cord-009571-mygj2nd4 425 11 of of IN cord-009571-mygj2nd4 425 12 in in IN cord-009571-mygj2nd4 425 13 vivo vivo NN cord-009571-mygj2nd4 425 14 polyclonal polyclonal JJ cord-009571-mygj2nd4 425 15 B B NNP cord-009571-mygj2nd4 425 16 cell cell NN cord-009571-mygj2nd4 425 17 activation activation NN cord-009571-mygj2nd4 425 18 , , , cord-009571-mygj2nd4 425 19 since since IN cord-009571-mygj2nd4 425 20 in in FW cord-009571-mygj2nd4 425 21 vitro vitro FW cord-009571-mygj2nd4 425 22 polyclonal polyclonal JJ cord-009571-mygj2nd4 425 23 activation activation NN cord-009571-mygj2nd4 425 24 of of IN cord-009571-mygj2nd4 425 25 m m NNP cord-009571-mygj2nd4 425 26 o o NN cord-009571-mygj2nd4 425 27 p p NN cord-009571-mygj2nd4 425 28 e e NN cord-009571-mygj2nd4 425 29 spleen spleen NN cord-009571-mygj2nd4 425 30 cells cell NNS cord-009571-mygj2nd4 425 31 has have VBZ cord-009571-mygj2nd4 425 32 been be VBN cord-009571-mygj2nd4 425 33 shown show VBN cord-009571-mygj2nd4 425 34 to to TO cord-009571-mygj2nd4 425 35 alter alter VB cord-009571-mygj2nd4 425 36 this this DT cord-009571-mygj2nd4 425 37 ratio ratio NN cord-009571-mygj2nd4 425 38 in in IN cord-009571-mygj2nd4 425 39 a a DT cord-009571-mygj2nd4 425 40 similar similar JJ cord-009571-mygj2nd4 425 41 manner manner NN cord-009571-mygj2nd4 425 42 . . . cord-009571-mygj2nd4 426 1 Since since IN cord-009571-mygj2nd4 426 2 the the DT cord-009571-mygj2nd4 426 3 increased increase VBN cord-009571-mygj2nd4 426 4 ratio ratio NN cord-009571-mygj2nd4 426 5 was be VBD cord-009571-mygj2nd4 426 6 noted note VBN cord-009571-mygj2nd4 426 7 as as RB cord-009571-mygj2nd4 426 8 early early RB cord-009571-mygj2nd4 426 9 as as IN cord-009571-mygj2nd4 426 10 6 6 CD cord-009571-mygj2nd4 426 11 weeks week NNS cord-009571-mygj2nd4 426 12 , , , cord-009571-mygj2nd4 426 13 these these DT cord-009571-mygj2nd4 426 14 data datum NNS cord-009571-mygj2nd4 426 15 provide provide VBP cord-009571-mygj2nd4 426 16 support support NN cord-009571-mygj2nd4 426 17 for for IN cord-009571-mygj2nd4 426 18 the the DT cord-009571-mygj2nd4 426 19 concept concept NN cord-009571-mygj2nd4 426 20 that that IN cord-009571-mygj2nd4 426 21 polyclonal polyclonal JJ cord-009571-mygj2nd4 426 22 B B NNP cord-009571-mygj2nd4 426 23 cell cell NN cord-009571-mygj2nd4 426 24 activation activation NN cord-009571-mygj2nd4 426 25 precedes precede VBZ cord-009571-mygj2nd4 426 26 the the DT cord-009571-mygj2nd4 426 27 onset onset NN cord-009571-mygj2nd4 426 28 of of IN cord-009571-mygj2nd4 426 29 autoimmune autoimmune JJ cord-009571-mygj2nd4 426 30 disease disease NN cord-009571-mygj2nd4 426 31 in in IN cord-009571-mygj2nd4 426 32 NZB nzb NN cord-009571-mygj2nd4 426 33 mice mouse NNS cord-009571-mygj2nd4 426 34 . . . cord-009571-mygj2nd4 427 1 Sera Sera NNP cord-009571-mygj2nd4 427 2 from from IN cord-009571-mygj2nd4 427 3 patients patient NNS cord-009571-mygj2nd4 427 4 with with IN cord-009571-mygj2nd4 427 5 systemic systemic JJ cord-009571-mygj2nd4 427 6 lupus lupus NN cord-009571-mygj2nd4 427 7 erythematosus erythematosus NN cord-009571-mygj2nd4 427 8 ( ( -LRB- cord-009571-mygj2nd4 427 9 SLE SLE NNP cord-009571-mygj2nd4 427 10 ) ) -RRB- cord-009571-mygj2nd4 427 11 will will MD cord-009571-mygj2nd4 427 12 bind bind VB cord-009571-mygj2nd4 427 13 native native JJ cord-009571-mygj2nd4 427 14 DNA DNA NNP cord-009571-mygj2nd4 427 15 ( ( -LRB- cord-009571-mygj2nd4 427 16 n n JJ cord-009571-mygj2nd4 427 17 - - HYPH cord-009571-mygj2nd4 427 18 DNA DNA NNP cord-009571-mygj2nd4 427 19 ) ) -RRB- cord-009571-mygj2nd4 427 20 . . . cord-009571-mygj2nd4 428 1 Poly Poly NNP cord-009571-mygj2nd4 428 2 dAT dAT NNP cord-009571-mygj2nd4 428 3 , , , cord-009571-mygj2nd4 428 4 a a DT cord-009571-mygj2nd4 428 5 synthetic synthetic JJ cord-009571-mygj2nd4 428 6 n n NN cord-009571-mygj2nd4 428 7 - - HYPH cord-009571-mygj2nd4 428 8 DNA dna NN cord-009571-mygj2nd4 428 9 , , , cord-009571-mygj2nd4 428 10 consists consist VBZ cord-009571-mygj2nd4 428 11 of of IN cord-009571-mygj2nd4 428 12 regularly regularly RB cord-009571-mygj2nd4 428 13 recurring recur VBG cord-009571-mygj2nd4 428 14 base base NN cord-009571-mygj2nd4 428 15 pairs pair NNS cord-009571-mygj2nd4 428 16 . . . cord-009571-mygj2nd4 429 1 This this DT cord-009571-mygj2nd4 429 2 results result VBZ cord-009571-mygj2nd4 429 3 in in IN cord-009571-mygj2nd4 429 4 a a DT cord-009571-mygj2nd4 429 5 restricted restrict VBN cord-009571-mygj2nd4 429 6 antigenicity antigenicity NN cord-009571-mygj2nd4 429 7 but but CC cord-009571-mygj2nd4 429 8 ensures ensure VBZ cord-009571-mygj2nd4 429 9 that that IN cord-009571-mygj2nd4 429 10 the the DT cord-009571-mygj2nd4 429 11 molecules molecule NNS cord-009571-mygj2nd4 429 12 do do VBP cord-009571-mygj2nd4 429 13 not not RB cord-009571-mygj2nd4 429 14 contain contain VB cord-009571-mygj2nd4 429 15 single single JJ cord-009571-mygj2nd4 429 16 - - HYPH cord-009571-mygj2nd4 429 17 stranded stranded JJ cord-009571-mygj2nd4 429 18 ( ( -LRB- cord-009571-mygj2nd4 429 19 ss ss NNP cord-009571-mygj2nd4 429 20 ) ) -RRB- cord-009571-mygj2nd4 429 21 regions region NNS cord-009571-mygj2nd4 429 22 . . . cord-009571-mygj2nd4 430 1 Many many JJ cord-009571-mygj2nd4 430 2 laboratory laboratory NN cord-009571-mygj2nd4 430 3 preparations preparation NNS cord-009571-mygj2nd4 430 4 of of IN cord-009571-mygj2nd4 430 5 n n JJ cord-009571-mygj2nd4 430 6 - - HYPH cord-009571-mygj2nd4 430 7 DNA DNA NNP cord-009571-mygj2nd4 430 8 will will MD cord-009571-mygj2nd4 430 9 be be VB cord-009571-mygj2nd4 430 10 contaminated contaminate VBN cord-009571-mygj2nd4 430 11 with with IN cord-009571-mygj2nd4 430 12 either either DT cord-009571-mygj2nd4 430 13 ss ss NNP cord-009571-mygj2nd4 430 14 DNA DNA NNP cord-009571-mygj2nd4 430 15 or or CC cord-009571-mygj2nd4 430 16 structures structure NNS cord-009571-mygj2nd4 430 17 with with IN cord-009571-mygj2nd4 430 18 ss ss NN cord-009571-mygj2nd4 430 19 regions region NNS cord-009571-mygj2nd4 430 20 in in IN cord-009571-mygj2nd4 430 21 predominantly predominantly RB cord-009571-mygj2nd4 430 22 duplex duplex JJ cord-009571-mygj2nd4 430 23 molecules molecule NNS cord-009571-mygj2nd4 430 24 . . . cord-009571-mygj2nd4 431 1 The the DT cord-009571-mygj2nd4 431 2 aim aim NN cord-009571-mygj2nd4 431 3 of of IN cord-009571-mygj2nd4 431 4 this this DT cord-009571-mygj2nd4 431 5 study study NN cord-009571-mygj2nd4 431 6 was be VBD cord-009571-mygj2nd4 431 7 to to TO cord-009571-mygj2nd4 431 8 determine determine VB cord-009571-mygj2nd4 431 9 a a DT cord-009571-mygj2nd4 431 10 relationship relationship NN cord-009571-mygj2nd4 431 11 between between IN cord-009571-mygj2nd4 431 12 antibodies antibody NNS cord-009571-mygj2nd4 431 13 to to IN cord-009571-mygj2nd4 431 14 poly poly NNP cord-009571-mygj2nd4 431 15 dAT dAT NNP cord-009571-mygj2nd4 431 16 and and CC cord-009571-mygj2nd4 431 17 native native JJ cord-009571-mygj2nd4 431 18 DNA dna NN cord-009571-mygj2nd4 431 19 in in IN cord-009571-mygj2nd4 431 20 individual individual JJ cord-009571-mygj2nd4 431 21 SLE SLE NNP cord-009571-mygj2nd4 431 22 sera sera NNP cord-009571-mygj2nd4 431 23 . . . cord-009571-mygj2nd4 432 1 One one CD cord-009571-mygj2nd4 432 2 hundred hundred CD cord-009571-mygj2nd4 432 3 sera sera NNP cord-009571-mygj2nd4 432 4 from from IN cord-009571-mygj2nd4 432 5 35 35 CD cord-009571-mygj2nd4 432 6 patients patient NNS cord-009571-mygj2nd4 432 7 with with IN cord-009571-mygj2nd4 432 8 SLE SLE NNP cord-009571-mygj2nd4 432 9 were be VBD cord-009571-mygj2nd4 432 10 used use VBN cord-009571-mygj2nd4 432 11 in in IN cord-009571-mygj2nd4 432 12 this this DT cord-009571-mygj2nd4 432 13 study study NN cord-009571-mygj2nd4 432 14 . . . cord-009571-mygj2nd4 433 1 Antibodies antibody NNS cord-009571-mygj2nd4 433 2 to to IN cord-009571-mygj2nd4 433 3 poly poly NNP cord-009571-mygj2nd4 433 4 dAT dAT NNP cord-009571-mygj2nd4 433 5 and and CC cord-009571-mygj2nd4 433 6 n n NNP cord-009571-mygj2nd4 433 7 - - HYPH cord-009571-mygj2nd4 433 8 DNA DNA NNP cord-009571-mygj2nd4 433 9 were be VBD cord-009571-mygj2nd4 433 10 measured measure VBN cord-009571-mygj2nd4 433 11 in in IN cord-009571-mygj2nd4 433 12 duplicate duplicate NN cord-009571-mygj2nd4 433 13 in in IN cord-009571-mygj2nd4 433 14 each each DT cord-009571-mygj2nd4 433 15 serum serum NN cord-009571-mygj2nd4 433 16 using use VBG cord-009571-mygj2nd4 433 17 a a DT cord-009571-mygj2nd4 433 18 millipore millipore NNP cord-009571-mygj2nd4 433 19 filter filter NN cord-009571-mygj2nd4 433 20 technique technique NN cord-009571-mygj2nd4 433 21 . . . cord-009571-mygj2nd4 434 1 Poly Poly NNP cord-009571-mygj2nd4 434 2 dAT dAT NNP cord-009571-mygj2nd4 434 3 was be VBD cord-009571-mygj2nd4 434 4 prepared prepare VBN cord-009571-mygj2nd4 434 5 from from IN cord-009571-mygj2nd4 435 1 dATP dATP NNP cord-009571-mygj2nd4 435 2 and and CC cord-009571-mygj2nd4 435 3 * * NFP cord-009571-mygj2nd4 435 4 H h NN cord-009571-mygj2nd4 435 5 labeled label VBN cord-009571-mygj2nd4 435 6 dTTP dttp JJ cord-009571-mygj2nd4 435 7 in in IN cord-009571-mygj2nd4 435 8 the the DT cord-009571-mygj2nd4 435 9 presence presence NN cord-009571-mygj2nd4 435 10 of of IN cord-009571-mygj2nd4 435 11 E e NN cord-009571-mygj2nd4 435 12 coli coli NN cord-009571-mygj2nd4 435 13 DNA dna NN cord-009571-mygj2nd4 435 14 polymerase polymerase NN cord-009571-mygj2nd4 435 15 . . . cord-009571-mygj2nd4 436 1 Native native JJ cord-009571-mygj2nd4 436 2 aH ah UH cord-009571-mygj2nd4 436 3 labeled label VBN cord-009571-mygj2nd4 436 4 DNA DNA NNP cord-009571-mygj2nd4 436 5 was be VBD cord-009571-mygj2nd4 436 6 extracted extract VBN cord-009571-mygj2nd4 436 7 from from IN cord-009571-mygj2nd4 436 8 HAE HAE NNP cord-009571-mygj2nd4 436 9 70 70 CD cord-009571-mygj2nd4 436 10 cells cell NNS cord-009571-mygj2nd4 436 11 after after IN cord-009571-mygj2nd4 436 12 incubation incubation NN cord-009571-mygj2nd4 436 13 with with IN cord-009571-mygj2nd4 436 14 ' ' '' cord-009571-mygj2nd4 436 15 H h NN cord-009571-mygj2nd4 436 16 thymidine thymidine NN cord-009571-mygj2nd4 436 17 . . . cord-009571-mygj2nd4 437 1 Optimal optimal JJ cord-009571-mygj2nd4 437 2 concentrations concentration NNS cord-009571-mygj2nd4 437 3 of of IN cord-009571-mygj2nd4 437 4 each each DT cord-009571-mygj2nd4 437 5 antigen antigen NN cord-009571-mygj2nd4 437 6 were be VBD cord-009571-mygj2nd4 437 7 calculated calculate VBN cord-009571-mygj2nd4 437 8 for for IN cord-009571-mygj2nd4 437 9 use use NN cord-009571-mygj2nd4 437 10 in in IN cord-009571-mygj2nd4 437 11 the the DT cord-009571-mygj2nd4 437 12 assay assay NN cord-009571-mygj2nd4 437 13 . . . cord-009571-mygj2nd4 438 1 Each each DT cord-009571-mygj2nd4 438 2 preparation preparation NN cord-009571-mygj2nd4 438 3 was be VBD cord-009571-mygj2nd4 438 4 structurally structurally RB cord-009571-mygj2nd4 438 5 analyzed analyze VBN cord-009571-mygj2nd4 438 6 by by IN cord-009571-mygj2nd4 438 7 both both DT cord-009571-mygj2nd4 438 8 hydroxyapatite hydroxyapatite NN cord-009571-mygj2nd4 438 9 ( ( -LRB- cord-009571-mygj2nd4 438 10 HAP HAP NNP cord-009571-mygj2nd4 438 11 ) ) -RRB- cord-009571-mygj2nd4 438 12 elution elution NNP cord-009571-mygj2nd4 438 13 studies study NNS cord-009571-mygj2nd4 438 14 and and CC cord-009571-mygj2nd4 438 15 ethidium ethidium NN cord-009571-mygj2nd4 438 16 bromide bromide NN cord-009571-mygj2nd4 438 17 fluorescence fluorescence NN cord-009571-mygj2nd4 438 18 ( ( -LRB- cord-009571-mygj2nd4 438 19 EBr EBr NNS cord-009571-mygj2nd4 438 20 ) ) -RRB- cord-009571-mygj2nd4 438 21 to to TO cord-009571-mygj2nd4 438 22 determine determine VB cord-009571-mygj2nd4 438 23 the the DT cord-009571-mygj2nd4 438 24 presence presence NN cord-009571-mygj2nd4 438 25 of of IN cord-009571-mygj2nd4 438 26 ss ss NNP cord-009571-mygj2nd4 438 27 DNA DNA NNP cord-009571-mygj2nd4 438 28 or or CC cord-009571-mygj2nd4 438 29 ss ss NN cord-009571-mygj2nd4 438 30 regions region NNS cord-009571-mygj2nd4 438 31 within within IN cord-009571-mygj2nd4 438 32 a a DT cord-009571-mygj2nd4 438 33 predominantly predominantly RB cord-009571-mygj2nd4 438 34 duplex duplex JJ cord-009571-mygj2nd4 438 35 molecule molecule NN cord-009571-mygj2nd4 438 36 . . . cord-009571-mygj2nd4 439 1 The the DT cord-009571-mygj2nd4 439 2 specificity specificity NN cord-009571-mygj2nd4 439 3 of of IN cord-009571-mygj2nd4 439 4 antibodies antibody NNS cord-009571-mygj2nd4 439 5 to to IN cord-009571-mygj2nd4 439 6 poly poly NNP cord-009571-mygj2nd4 439 7 dAT dAT NNP cord-009571-mygj2nd4 439 8 and and CC cord-009571-mygj2nd4 439 9 n n NNP cord-009571-mygj2nd4 439 10 - - HYPH cord-009571-mygj2nd4 439 11 DNA DNA NNP cord-009571-mygj2nd4 439 12 was be VBD cord-009571-mygj2nd4 439 13 assessed assess VBN cord-009571-mygj2nd4 439 14 by by IN cord-009571-mygj2nd4 439 15 passing pass VBG cord-009571-mygj2nd4 439 16 sera sera NNP cord-009571-mygj2nd4 439 17 over over IN cord-009571-mygj2nd4 439 18 agarose agarose JJ cord-009571-mygj2nd4 439 19 columns column NNS cord-009571-mygj2nd4 439 20 bound bind VBN cord-009571-mygj2nd4 439 21 to to IN cord-009571-mygj2nd4 439 22 either either DT cord-009571-mygj2nd4 439 23 circular circular JJ cord-009571-mygj2nd4 439 24 PM2 pm2 JJ cord-009571-mygj2nd4 439 25 DNA DNA NNP cord-009571-mygj2nd4 439 26 or or CC cord-009571-mygj2nd4 439 27 poly poly JJ cord-009571-mygj2nd4 439 28 dAT dat NN cord-009571-mygj2nd4 439 29 and and CC cord-009571-mygj2nd4 439 30 measuring measure VBG cord-009571-mygj2nd4 439 31 both both CC cord-009571-mygj2nd4 439 32 n n JJ cord-009571-mygj2nd4 439 33 - - HYPH cord-009571-mygj2nd4 439 34 DNA DNA NNP cord-009571-mygj2nd4 439 35 and and CC cord-009571-mygj2nd4 439 36 poly poly NNP cord-009571-mygj2nd4 439 37 dAT dAT NNP cord-009571-mygj2nd4 439 38 antibodies antibody NNS cord-009571-mygj2nd4 439 39 in in IN cord-009571-mygj2nd4 439 40 serum serum NN cord-009571-mygj2nd4 439 41 and and CC cord-009571-mygj2nd4 439 42 eluate eluate NN cord-009571-mygj2nd4 439 43 . . . cord-009571-mygj2nd4 440 1 Neither neither DT cord-009571-mygj2nd4 440 2 preparation preparation NN cord-009571-mygj2nd4 440 3 contained contain VBD cord-009571-mygj2nd4 440 4 ss ss NNP cord-009571-mygj2nd4 440 5 DNA DNA NNP cord-009571-mygj2nd4 440 6 assessed assess VBN cord-009571-mygj2nd4 440 7 by by IN cord-009571-mygj2nd4 440 8 HAP HAP NNP cord-009571-mygj2nd4 440 9 elution elution NNP cord-009571-mygj2nd4 440 10 . . . cord-009571-mygj2nd4 441 1 Poly Poly NNP cord-009571-mygj2nd4 441 2 dAT dAT NNP cord-009571-mygj2nd4 441 3 was be VBD cord-009571-mygj2nd4 441 4 entirely entirely RB cord-009571-mygj2nd4 441 5 duplex duplex JJ cord-009571-mygj2nd4 441 6 as as IN cord-009571-mygj2nd4 441 7 assessed assess VBN cord-009571-mygj2nd4 441 8 by by IN cord-009571-mygj2nd4 441 9 EBr EBr NNS cord-009571-mygj2nd4 441 10 fluorescence fluorescence NN cord-009571-mygj2nd4 441 11 but but CC cord-009571-mygj2nd4 441 12 our -PRON- PRP$ cord-009571-mygj2nd4 441 13 n n JJ cord-009571-mygj2nd4 441 14 - - HYPH cord-009571-mygj2nd4 441 15 DNA DNA NNP cord-009571-mygj2nd4 441 16 contained contain VBD cord-009571-mygj2nd4 441 17 15 15 CD cord-009571-mygj2nd4 441 18 % % NN cord-009571-mygj2nd4 441 19 ss ss NN cord-009571-mygj2nd4 441 20 regions region NNS cord-009571-mygj2nd4 441 21 within within IN cord-009571-mygj2nd4 441 22 the the DT cord-009571-mygj2nd4 441 23 predominantly predominantly RB cord-009571-mygj2nd4 441 24 duplex duplex JJ cord-009571-mygj2nd4 441 25 molecules molecule NNS cord-009571-mygj2nd4 441 26 . . . cord-009571-mygj2nd4 442 1 Under under IN cord-009571-mygj2nd4 442 2 optimal optimal JJ cord-009571-mygj2nd4 442 3 conditions condition NNS cord-009571-mygj2nd4 442 4 each each DT cord-009571-mygj2nd4 442 5 serum serum NN cord-009571-mygj2nd4 442 6 showed show VBD cord-009571-mygj2nd4 442 7 consistently consistently RB cord-009571-mygj2nd4 442 8 less less RBR cord-009571-mygj2nd4 442 9 binding binding JJ cord-009571-mygj2nd4 442 10 to to IN cord-009571-mygj2nd4 442 11 poly poly NNP cord-009571-mygj2nd4 442 12 dAT dat NN cord-009571-mygj2nd4 442 13 than than IN cord-009571-mygj2nd4 442 14 to to IN cord-009571-mygj2nd4 442 15 n n CD cord-009571-mygj2nd4 442 16 - - HYPH cord-009571-mygj2nd4 442 17 DNA dna NN cord-009571-mygj2nd4 442 18 . . . cord-009571-mygj2nd4 443 1 A a DT cord-009571-mygj2nd4 443 2 significant significant JJ cord-009571-mygj2nd4 443 3 correlation correlation NN cord-009571-mygj2nd4 443 4 was be VBD cord-009571-mygj2nd4 443 5 seen see VBN cord-009571-mygj2nd4 443 6 between between IN cord-009571-mygj2nd4 443 7 the the DT cord-009571-mygj2nd4 443 8 binding binding NN cord-009571-mygj2nd4 443 9 to to IN cord-009571-mygj2nd4 443 10 poly poly NNP cord-009571-mygj2nd4 443 11 dAT dAT NNP cord-009571-mygj2nd4 443 12 and and CC cord-009571-mygj2nd4 443 13 n n NNP cord-009571-mygj2nd4 443 14 - - HYPH cord-009571-mygj2nd4 443 15 DNA DNA NNP cord-009571-mygj2nd4 443 16 ( ( -LRB- cord-009571-mygj2nd4 443 17 r r NN cord-009571-mygj2nd4 443 18 = = SYM cord-009571-mygj2nd4 443 19 0.91 0.91 CD cord-009571-mygj2nd4 443 20 , , , cord-009571-mygj2nd4 443 21 P p NN cord-009571-mygj2nd4 443 22 < < XX cord-009571-mygj2nd4 443 23 0.01 0.01 CD cord-009571-mygj2nd4 443 24 ) ) -RRB- cord-009571-mygj2nd4 443 25 . . . cord-009571-mygj2nd4 444 1 This this DT cord-009571-mygj2nd4 444 2 correlation correlation NN cord-009571-mygj2nd4 444 3 was be VBD cord-009571-mygj2nd4 444 4 consistent consistent JJ cord-009571-mygj2nd4 444 5 in in IN cord-009571-mygj2nd4 444 6 all all DT cord-009571-mygj2nd4 444 7 sera sera NNP cord-009571-mygj2nd4 444 8 tested test VBN cord-009571-mygj2nd4 444 9 and and CC cord-009571-mygj2nd4 444 10 no no DT cord-009571-mygj2nd4 444 11 serum serum NN cord-009571-mygj2nd4 444 12 showed show VBD cord-009571-mygj2nd4 444 13 exclusive exclusive JJ cord-009571-mygj2nd4 444 14 binding binding NN cord-009571-mygj2nd4 444 15 to to IN cord-009571-mygj2nd4 444 16 only only RB cord-009571-mygj2nd4 444 17 one one CD cord-009571-mygj2nd4 444 18 preparation preparation NN cord-009571-mygj2nd4 444 19 . . . cord-009571-mygj2nd4 445 1 Binding bind VBG cord-009571-mygj2nd4 445 2 to to IN cord-009571-mygj2nd4 445 3 both both DT cord-009571-mygj2nd4 445 4 antigens antigen NNS cord-009571-mygj2nd4 445 5 could could MD cord-009571-mygj2nd4 445 6 be be VB cord-009571-mygj2nd4 445 7 removed remove VBN cord-009571-mygj2nd4 445 8 by by IN cord-009571-mygj2nd4 445 9 passing pass VBG cord-009571-mygj2nd4 445 10 a a DT cord-009571-mygj2nd4 445 11 serum serum NN cord-009571-mygj2nd4 445 12 over over IN cord-009571-mygj2nd4 445 13 an an DT cord-009571-mygj2nd4 445 14 agarose agarose JJ cord-009571-mygj2nd4 445 15 column column NN cord-009571-mygj2nd4 445 16 carrying carry VBG cord-009571-mygj2nd4 445 17 either either CC cord-009571-mygj2nd4 445 18 poly poly NNP cord-009571-mygj2nd4 445 19 dAT dAT NNP cord-009571-mygj2nd4 445 20 or or CC cord-009571-mygj2nd4 445 21 n n NNP cord-009571-mygj2nd4 445 22 - - HYPH cord-009571-mygj2nd4 445 23 DNA dna NN cord-009571-mygj2nd4 445 24 . . . cord-009571-mygj2nd4 446 1 These these DT cord-009571-mygj2nd4 446 2 results result NNS cord-009571-mygj2nd4 446 3 suggest suggest VBP cord-009571-mygj2nd4 446 4 that that IN cord-009571-mygj2nd4 446 5 in in IN cord-009571-mygj2nd4 446 6 clinical clinical JJ cord-009571-mygj2nd4 446 7 practice practice NN cord-009571-mygj2nd4 446 8 diagnosis diagnosis NN cord-009571-mygj2nd4 446 9 and and CC cord-009571-mygj2nd4 446 10 management management NN cord-009571-mygj2nd4 446 11 of of IN cord-009571-mygj2nd4 446 12 SLE SLE NNP cord-009571-mygj2nd4 446 13 will will MD cord-009571-mygj2nd4 446 14 be be VB cord-009571-mygj2nd4 446 15 provided provide VBN cord-009571-mygj2nd4 446 16 by by IN cord-009571-mygj2nd4 446 17 measurement measurement NN cord-009571-mygj2nd4 446 18 of of IN cord-009571-mygj2nd4 446 19 antibodies antibody NNS cord-009571-mygj2nd4 446 20 to to IN cord-009571-mygj2nd4 446 21 either either DT cord-009571-mygj2nd4 446 22 poly poly NNP cord-009571-mygj2nd4 446 23 dAT dAT NNP cord-009571-mygj2nd4 446 24 or or CC cord-009571-mygj2nd4 446 25 n n NNP cord-009571-mygj2nd4 446 26 - - HYPH cord-009571-mygj2nd4 446 27 DNA dna NN cord-009571-mygj2nd4 446 28 provided provide VBD cord-009571-mygj2nd4 446 29 that that IN cord-009571-mygj2nd4 446 30 the the DT cord-009571-mygj2nd4 446 31 n n JJ cord-009571-mygj2nd4 446 32 - - HYPH cord-009571-mygj2nd4 446 33 DNA dna NN cord-009571-mygj2nd4 446 34 preparation preparation NN cord-009571-mygj2nd4 446 35 is be VBZ cord-009571-mygj2nd4 446 36 well well RB cord-009571-mygj2nd4 446 37 characterized characterized JJ cord-009571-mygj2nd4 446 38 and and CC cord-009571-mygj2nd4 446 39 does do VBZ cord-009571-mygj2nd4 446 40 not not RB cord-009571-mygj2nd4 446 41 contain contain VB cord-009571-mygj2nd4 446 42 ss ss NNP cord-009571-mygj2nd4 446 43 DNA DNA NNP cord-009571-mygj2nd4 446 44 or or CC cord-009571-mygj2nd4 446 45 significant significant JJ cord-009571-mygj2nd4 446 46 ss ss NN cord-009571-mygj2nd4 446 47 regions region NNS cord-009571-mygj2nd4 446 48 . . . cord-009571-mygj2nd4 447 1 Despite despite IN cord-009571-mygj2nd4 447 2 its -PRON- PRP$ cord-009571-mygj2nd4 447 3 limited limited JJ cord-009571-mygj2nd4 447 4 potential potential JJ cord-009571-mygj2nd4 447 5 antigenic antigenic JJ cord-009571-mygj2nd4 447 6 sites site NNS cord-009571-mygj2nd4 447 7 , , , cord-009571-mygj2nd4 447 8 poly poly NNP cord-009571-mygj2nd4 447 9 dAT dAT NNP cord-009571-mygj2nd4 447 10 provides provide VBZ cord-009571-mygj2nd4 447 11 a a DT cord-009571-mygj2nd4 447 12 useful useful JJ cord-009571-mygj2nd4 447 13 alternative alternative NN cord-009571-mygj2nd4 447 14 to to IN cord-009571-mygj2nd4 447 15 n n NN cord-009571-mygj2nd4 447 16 - - HYPH cord-009571-mygj2nd4 447 17 DNA dna NN cord-009571-mygj2nd4 447 18 and and CC cord-009571-mygj2nd4 447 19 does do VBZ cord-009571-mygj2nd4 447 20 not not RB cord-009571-mygj2nd4 447 21 possess possess VB cord-009571-mygj2nd4 447 22 ss ss NN cord-009571-mygj2nd4 447 23 regions region NNS cord-009571-mygj2nd4 447 24 to to TO cord-009571-mygj2nd4 447 25 which which WDT cord-009571-mygj2nd4 447 26 other other JJ cord-009571-mygj2nd4 447 27 antibodies antibody NNS cord-009571-mygj2nd4 447 28 may may MD cord-009571-mygj2nd4 447 29 bind bind VB cord-009571-mygj2nd4 447 30 with with IN cord-009571-mygj2nd4 447 31 less less RBR cord-009571-mygj2nd4 447 32 diagnostic diagnostic JJ cord-009571-mygj2nd4 447 33 specificity specificity NN cord-009571-mygj2nd4 447 34 . . . cord-009571-mygj2nd4 448 1 Cultured cultured JJ cord-009571-mygj2nd4 448 2 adherent adherent JJ cord-009571-mygj2nd4 448 3 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 448 4 synovial synovial NN cord-009571-mygj2nd4 448 5 cells cell NNS cord-009571-mygj2nd4 448 6 ( ( -LRB- cord-009571-mygj2nd4 448 7 ASC ASC NNP cord-009571-mygj2nd4 448 8 ) ) -RRB- cord-009571-mygj2nd4 448 9 produce produce VBP cord-009571-mygj2nd4 448 10 collagenase collagenase NN cord-009571-mygj2nd4 448 11 and and CC cord-009571-mygj2nd4 448 12 prostaglandins prostaglandin NNS cord-009571-mygj2nd4 448 13 , , , cord-009571-mygj2nd4 448 14 particularly particularly RB cord-009571-mygj2nd4 448 15 PGE PGE NNP cord-009571-mygj2nd4 448 16 ; ; : cord-009571-mygj2nd4 448 17 . . . cord-009571-mygj2nd4 449 1 With with IN cord-009571-mygj2nd4 449 2 age age NN cord-009571-mygj2nd4 449 3 in in IN cord-009571-mygj2nd4 449 4 culture culture NN cord-009571-mygj2nd4 449 5 and and CC cord-009571-mygj2nd4 449 6 passage passage NN cord-009571-mygj2nd4 449 7 , , , cord-009571-mygj2nd4 449 8 collagenase collagenase NNP cord-009571-mygj2nd4 449 9 and and CC cord-009571-mygj2nd4 449 10 PGE PGE NNP cord-009571-mygj2nd4 449 11 , , , cord-009571-mygj2nd4 449 12 production production NN cord-009571-mygj2nd4 449 13 decrease decrease NN cord-009571-mygj2nd4 449 14 ; ; : cord-009571-mygj2nd4 449 15 however however RB cord-009571-mygj2nd4 449 16 , , , cord-009571-mygj2nd4 449 17 release release NN cord-009571-mygj2nd4 449 18 of of IN cord-009571-mygj2nd4 449 19 these these DT cord-009571-mygj2nd4 449 20 substances substance NNS cord-009571-mygj2nd4 449 21 can can MD cord-009571-mygj2nd4 449 22 be be VB cord-009571-mygj2nd4 449 23 stimulated stimulate VBN cord-009571-mygj2nd4 449 24 up up RP cord-009571-mygj2nd4 449 25 to to IN cord-009571-mygj2nd4 449 26 > > XX cord-009571-mygj2nd4 450 1 one one CD cord-009571-mygj2nd4 450 2 hundredfold hundredfold NN cord-009571-mygj2nd4 450 3 by by IN cord-009571-mygj2nd4 450 4 a a DT cord-009571-mygj2nd4 450 5 factor factor NN cord-009571-mygj2nd4 450 6 ( ( -LRB- cord-009571-mygj2nd4 450 7 apparent apparent JJ cord-009571-mygj2nd4 450 8 mol mol NN cord-009571-mygj2nd4 450 9 wt wt NN cord-009571-mygj2nd4 450 10 of of IN cord-009571-mygj2nd4 450 11 -14,000 -14,000 NNP cord-009571-mygj2nd4 450 12 ) ) -RRB- cord-009571-mygj2nd4 450 13 released release VBN cord-009571-mygj2nd4 450 14 by by IN cord-009571-mygj2nd4 450 15 cultured cultured JJ cord-009571-mygj2nd4 450 16 human human JJ cord-009571-mygj2nd4 450 17 peripheral peripheral JJ cord-009571-mygj2nd4 450 18 blood blood NN cord-009571-mygj2nd4 450 19 mononuclear mononuclear NN cord-009571-mygj2nd4 450 20 cells cell NNS cord-009571-mygj2nd4 450 21 ( ( -LRB- cord-009571-mygj2nd4 450 22 MCF MCF NNP cord-009571-mygj2nd4 450 23 ) ) -RRB- cord-009571-mygj2nd4 450 24 . . . cord-009571-mygj2nd4 451 1 MCF MCF NNP cord-009571-mygj2nd4 451 2 stimulation stimulation NN cord-009571-mygj2nd4 451 3 of of IN cord-009571-mygj2nd4 451 4 collagenase collagenase JJ cord-009571-mygj2nd4 451 5 production production NN cord-009571-mygj2nd4 451 6 by by IN cord-009571-mygj2nd4 451 7 ASC ASC NNP cord-009571-mygj2nd4 451 8 is be VBZ cord-009571-mygj2nd4 451 9 enhanced enhance VBN cord-009571-mygj2nd4 451 10 by by IN cord-009571-mygj2nd4 451 11 addition addition NN cord-009571-mygj2nd4 451 12 of of IN cord-009571-mygj2nd4 451 13 low low JJ cord-009571-mygj2nd4 451 14 concentrations concentration NNS cord-009571-mygj2nd4 451 15 of of IN cord-009571-mygj2nd4 451 16 indomethacin indomethacin NN cord-009571-mygj2nd4 451 17 ( ( -LRB- cord-009571-mygj2nd4 451 18 indo indo NNP cord-009571-mygj2nd4 451 19 ) ) -RRB- cord-009571-mygj2nd4 451 20 , , , cord-009571-mygj2nd4 451 21 1 1 CD cord-009571-mygj2nd4 451 22 nM nm CD cord-009571-mygj2nd4 451 23 ; ; : cord-009571-mygj2nd4 451 24 such such JJ cord-009571-mygj2nd4 451 25 concentrations concentration NNS cord-009571-mygj2nd4 451 26 of of IN cord-009571-mygj2nd4 451 27 indo indo NNP cord-009571-mygj2nd4 451 28 block block NN cord-009571-mygj2nd4 451 29 PGE PGE NNP cord-009571-mygj2nd4 451 30 , , , cord-009571-mygj2nd4 451 31 synthesis synthesis NN cord-009571-mygj2nd4 452 1 > > XX cord-009571-mygj2nd4 453 1 5Wo 5wo CD cord-009571-mygj2nd4 453 2 even even RB cord-009571-mygj2nd4 453 3 in in IN cord-009571-mygj2nd4 453 4 the the DT cord-009571-mygj2nd4 453 5 presence presence NN cord-009571-mygj2nd4 453 6 of of IN cord-009571-mygj2nd4 453 7 MCF MCF NNP cord-009571-mygj2nd4 453 8 . . . cord-009571-mygj2nd4 454 1 At at IN cord-009571-mygj2nd4 454 2 higher high JJR cord-009571-mygj2nd4 454 3 indo indo NNP cord-009571-mygj2nd4 454 4 concentrations concentration NNS cord-009571-mygj2nd4 454 5 ( ( -LRB- cord-009571-mygj2nd4 454 6 1 1 CD cord-009571-mygj2nd4 454 7 - - SYM cord-009571-mygj2nd4 454 8 10 10 CD cord-009571-mygj2nd4 454 9 fiM fiM NNP cord-009571-mygj2nd4 454 10 ) ) -RRB- cord-009571-mygj2nd4 454 11 which which WDT cord-009571-mygj2nd4 454 12 inhibit inhibit VBP cord-009571-mygj2nd4 454 13 PGE PGE NNP cord-009571-mygj2nd4 454 14 , , , cord-009571-mygj2nd4 454 15 synthesis synthesis NN cord-009571-mygj2nd4 454 16 -1008 -1008 NNP cord-009571-mygj2nd4 454 17 , , , cord-009571-mygj2nd4 454 18 collagenase collagenase JJ cord-009571-mygj2nd4 454 19 stimulation stimulation NN cord-009571-mygj2nd4 454 20 is be VBZ cord-009571-mygj2nd4 454 21 usually usually RB cord-009571-mygj2nd4 454 22 inhibited inhibit VBN cord-009571-mygj2nd4 454 23 by by IN cord-009571-mygj2nd4 454 24 -60 -60 NNS cord-009571-mygj2nd4 454 25 % % NN cord-009571-mygj2nd4 454 26 . . . cord-009571-mygj2nd4 455 1 In in IN cord-009571-mygj2nd4 455 2 some some DT cord-009571-mygj2nd4 455 3 ASC ASC NNP cord-009571-mygj2nd4 455 4 stimulated stimulate VBD cord-009571-mygj2nd4 455 5 with with IN cord-009571-mygj2nd4 455 6 MCF MCF NNP cord-009571-mygj2nd4 455 7 , , , cord-009571-mygj2nd4 455 8 this this DT cord-009571-mygj2nd4 455 9 inhibition inhibition NN cord-009571-mygj2nd4 455 10 by by IN cord-009571-mygj2nd4 455 11 indo indo NNP cord-009571-mygj2nd4 455 12 ( ( -LRB- cord-009571-mygj2nd4 455 13 10 10 CD cord-009571-mygj2nd4 455 14 pM pm NN cord-009571-mygj2nd4 455 15 ) ) -RRB- cord-009571-mygj2nd4 455 16 is be VBZ cord-009571-mygj2nd4 455 17 reversed reverse VBN cord-009571-mygj2nd4 455 18 by by IN cord-009571-mygj2nd4 455 19 addition addition NN cord-009571-mygj2nd4 455 20 of of IN cord-009571-mygj2nd4 455 21 small small JJ cord-009571-mygj2nd4 455 22 amounts amount NNS cord-009571-mygj2nd4 455 23 of of IN cord-009571-mygj2nd4 455 24 PGE PGE NNP cord-009571-mygj2nd4 455 25 , , , cord-009571-mygj2nd4 455 26 ( ( -LRB- cord-009571-mygj2nd4 455 27 10 10 CD cord-009571-mygj2nd4 455 28 ng ng NN cord-009571-mygj2nd4 455 29 / / SYM cord-009571-mygj2nd4 455 30 ml ml NN cord-009571-mygj2nd4 455 31 ) ) -RRB- cord-009571-mygj2nd4 455 32 . . . cord-009571-mygj2nd4 456 1 Addition addition NN cord-009571-mygj2nd4 456 2 of of IN cord-009571-mygj2nd4 456 3 these these DT cord-009571-mygj2nd4 456 4 small small JJ cord-009571-mygj2nd4 456 5 amounts amount NNS cord-009571-mygj2nd4 456 6 of of IN cord-009571-mygj2nd4 456 7 PGE PGE NNP cord-009571-mygj2nd4 456 8 , , , cord-009571-mygj2nd4 456 9 results result VBZ cord-009571-mygj2nd4 456 10 in in IN cord-009571-mygj2nd4 456 11 augmentation augmentation NN cord-009571-mygj2nd4 456 12 of of IN cord-009571-mygj2nd4 456 13 collagenase collagenase JJ cord-009571-mygj2nd4 456 14 stimulation stimulation NN cord-009571-mygj2nd4 456 15 to to IN cord-009571-mygj2nd4 456 16 levels level NNS cord-009571-mygj2nd4 456 17 greater great JJR cord-009571-mygj2nd4 456 18 than than IN cord-009571-mygj2nd4 456 19 those those DT cord-009571-mygj2nd4 456 20 seen see VBN cord-009571-mygj2nd4 456 21 when when WRB cord-009571-mygj2nd4 456 22 cells cell NNS cord-009571-mygj2nd4 456 23 are be VBP cord-009571-mygj2nd4 456 24 stimulated stimulate VBN cord-009571-mygj2nd4 456 25 with with IN cord-009571-mygj2nd4 456 26 MCF MCF NNP cord-009571-mygj2nd4 456 27 alone alone JJ cord-009571-mygj2nd4 456 28 . . . cord-009571-mygj2nd4 457 1 Addition addition NN cord-009571-mygj2nd4 457 2 of of IN cord-009571-mygj2nd4 457 3 larger large JJR cord-009571-mygj2nd4 457 4 amounts amount NNS cord-009571-mygj2nd4 457 5 of of IN cord-009571-mygj2nd4 457 6 PGE PGE NNP cord-009571-mygj2nd4 457 7 , , , cord-009571-mygj2nd4 457 8 ( ( -LRB- cord-009571-mygj2nd4 457 9 1 1 CD cord-009571-mygj2nd4 457 10 pg pg NN cord-009571-mygj2nd4 457 11 / / SYM cord-009571-mygj2nd4 457 12 ml ml NN cord-009571-mygj2nd4 457 13 ) ) -RRB- cord-009571-mygj2nd4 457 14 under under IN cord-009571-mygj2nd4 457 15 these these DT cord-009571-mygj2nd4 457 16 conditions condition NNS cord-009571-mygj2nd4 457 17 tends tend VBZ cord-009571-mygj2nd4 457 18 to to TO cord-009571-mygj2nd4 457 19 inhibit inhibit VB cord-009571-mygj2nd4 457 20 collagenase collagenase NNP cord-009571-mygj2nd4 457 21 . . . cord-009571-mygj2nd4 458 1 ASC ASC NNP cord-009571-mygj2nd4 458 2 respond respond VBP cord-009571-mygj2nd4 458 3 to to IN cord-009571-mygj2nd4 458 4 exogenous exogenous JJ cord-009571-mygj2nd4 458 5 PGE PGE NNP cord-009571-mygj2nd4 458 6 , , , cord-009571-mygj2nd4 458 7 with with IN cord-009571-mygj2nd4 458 8 increased increase VBN cord-009571-mygj2nd4 458 9 levels level NNS cord-009571-mygj2nd4 458 10 of of IN cord-009571-mygj2nd4 458 11 CAMP camp NN cord-009571-mygj2nd4 458 12 . . . cord-009571-mygj2nd4 459 1 MCF MCF NNP cord-009571-mygj2nd4 459 2 also also RB cord-009571-mygj2nd4 459 3 modulates modulate VBZ cord-009571-mygj2nd4 459 4 this this DT cord-009571-mygj2nd4 459 5 cAMP camp NN cord-009571-mygj2nd4 459 6 response response NN cord-009571-mygj2nd4 459 7 : : : cord-009571-mygj2nd4 460 1 preincubation preincubation NN cord-009571-mygj2nd4 460 2 of of IN cord-009571-mygj2nd4 460 3 ASC ASC NNP cord-009571-mygj2nd4 460 4 with with IN cord-009571-mygj2nd4 460 5 either either CC cord-009571-mygj2nd4 460 6 indo indo NNP cord-009571-mygj2nd4 460 7 or or CC cord-009571-mygj2nd4 460 8 MCF MCF NNP cord-009571-mygj2nd4 460 9 plus plus CC cord-009571-mygj2nd4 460 10 indo indo NNP cord-009571-mygj2nd4 460 11 augments augment VBZ cord-009571-mygj2nd4 460 12 cAMP camp NN cord-009571-mygj2nd4 460 13 response response NN cord-009571-mygj2nd4 460 14 to to IN cord-009571-mygj2nd4 460 15 exogenous exogenous JJ cord-009571-mygj2nd4 460 16 P p NN cord-009571-mygj2nd4 460 17 G g NN cord-009571-mygj2nd4 460 18 b b NN cord-009571-mygj2nd4 460 19 . . . cord-009571-mygj2nd4 461 1 It -PRON- PRP cord-009571-mygj2nd4 461 2 is be VBZ cord-009571-mygj2nd4 461 3 possible possible JJ cord-009571-mygj2nd4 461 4 that that IN cord-009571-mygj2nd4 461 5 some some DT cord-009571-mygj2nd4 461 6 of of IN cord-009571-mygj2nd4 461 7 the the DT cord-009571-mygj2nd4 461 8 effects effect NNS cord-009571-mygj2nd4 461 9 of of IN cord-009571-mygj2nd4 461 10 PGE PGE NNP cord-009571-mygj2nd4 461 11 , , , cord-009571-mygj2nd4 461 12 on on IN cord-009571-mygj2nd4 461 13 collagenase collagenase NNP cord-009571-mygj2nd4 461 14 in in IN cord-009571-mygj2nd4 461 15 ASC ASC NNP cord-009571-mygj2nd4 461 16 are be VBP cord-009571-mygj2nd4 461 17 mediated mediate VBN cord-009571-mygj2nd4 461 18 through through IN cord-009571-mygj2nd4 461 19 adenylate adenylate NN cord-009571-mygj2nd4 461 20 cyclase cyclase NN cord-009571-mygj2nd4 461 21 . . . cord-009571-mygj2nd4 462 1 PGE PGE NNP cord-009571-mygj2nd4 462 2 , , , cord-009571-mygj2nd4 462 3 levels level NNS cord-009571-mygj2nd4 462 4 thus thus RB cord-009571-mygj2nd4 462 5 have have VBP cord-009571-mygj2nd4 462 6 profound profound JJ cord-009571-mygj2nd4 462 7 effects effect NNS cord-009571-mygj2nd4 462 8 on on IN cord-009571-mygj2nd4 462 9 collagenase collagenase NN cord-009571-mygj2nd4 462 10 production production NN cord-009571-mygj2nd4 462 11 by by IN cord-009571-mygj2nd4 462 12 ASC ASC NNP cord-009571-mygj2nd4 462 13 and and CC cord-009571-mygj2nd4 462 14 modulate modulate VB cord-009571-mygj2nd4 462 15 collagenase collagenase NN cord-009571-mygj2nd4 462 16 response response NN cord-009571-mygj2nd4 462 17 to to IN cord-009571-mygj2nd4 462 18 stimulation stimulation NN cord-009571-mygj2nd4 462 19 with with IN cord-009571-mygj2nd4 462 20 MCF MCF NNP cord-009571-mygj2nd4 462 21 . . . cord-009571-mygj2nd4 463 1 Therefore therefore RB cord-009571-mygj2nd4 463 2 , , , cord-009571-mygj2nd4 463 3 PGE PGE NNP cord-009571-mygj2nd4 463 4 , , , cord-009571-mygj2nd4 463 5 inhibition inhibition NN cord-009571-mygj2nd4 463 6 with with IN cord-009571-mygj2nd4 463 7 pharmacologic pharmacologic JJ cord-009571-mygj2nd4 463 8 agents agent NNS cord-009571-mygj2nd4 463 9 in in IN cord-009571-mygj2nd4 463 10 vivo vivo NN cord-009571-mygj2nd4 463 11 could could MD cord-009571-mygj2nd4 463 12 have have VB cord-009571-mygj2nd4 463 13 beneficial beneficial JJ cord-009571-mygj2nd4 463 14 or or CC cord-009571-mygj2nd4 463 15 deleterious deleterious JJ cord-009571-mygj2nd4 463 16 effects effect NNS cord-009571-mygj2nd4 463 17 with with IN cord-009571-mygj2nd4 463 18 regard regard NN cord-009571-mygj2nd4 463 19 to to IN cord-009571-mygj2nd4 463 20 connective connective JJ cord-009571-mygj2nd4 463 21 tissue tissue NN cord-009571-mygj2nd4 463 22 destruction destruction NN cord-009571-mygj2nd4 463 23 depending depend VBG cord-009571-mygj2nd4 463 24 upon upon IN cord-009571-mygj2nd4 463 25 the the DT cord-009571-mygj2nd4 463 26 type type NN cord-009571-mygj2nd4 463 27 , , , cord-009571-mygj2nd4 463 28 sensitivity sensitivity NN cord-009571-mygj2nd4 463 29 , , , cord-009571-mygj2nd4 463 30 and and CC cord-009571-mygj2nd4 463 31 prior prior JJ cord-009571-mygj2nd4 463 32 environment environment NN cord-009571-mygj2nd4 463 33 of of IN cord-009571-mygj2nd4 463 34 the the DT cord-009571-mygj2nd4 463 35 responding respond VBG cord-009571-mygj2nd4 463 36 cell cell NN cord-009571-mygj2nd4 463 37 . . . cord-009571-mygj2nd4 464 1 Ty ty NN cord-009571-mygj2nd4 464 2 cells cell NNS cord-009571-mygj2nd4 464 3 , , , cord-009571-mygj2nd4 464 4 a a DT cord-009571-mygj2nd4 464 5 subset subset NN cord-009571-mygj2nd4 464 6 of of IN cord-009571-mygj2nd4 464 7 T t NN cord-009571-mygj2nd4 464 8 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 464 9 , , , cord-009571-mygj2nd4 464 10 bear bear NNP cord-009571-mygj2nd4 464 11 Fc Fc NNP cord-009571-mygj2nd4 464 12 receptors receptor NNS cord-009571-mygj2nd4 464 13 for for IN cord-009571-mygj2nd4 464 14 IgG IgG NNP cord-009571-mygj2nd4 464 15 and and CC cord-009571-mygj2nd4 464 16 have have VBP cord-009571-mygj2nd4 464 17 suppressor suppressor NN cord-009571-mygj2nd4 464 18 activity activity NN cord-009571-mygj2nd4 464 19 for for IN cord-009571-mygj2nd4 464 20 antibody antibody NN cord-009571-mygj2nd4 464 21 production production NN cord-009571-mygj2nd4 464 22 after after IN cord-009571-mygj2nd4 464 23 activation activation NN cord-009571-mygj2nd4 464 24 with with IN cord-009571-mygj2nd4 464 25 IgG IgG NNP cord-009571-mygj2nd4 464 26 immune immune JJ cord-009571-mygj2nd4 464 27 complexes complex NNS cord-009571-mygj2nd4 464 28 . . . cord-009571-mygj2nd4 465 1 Levels level NNS cord-009571-mygj2nd4 465 2 of of IN cord-009571-mygj2nd4 465 3 Ty ty NN cord-009571-mygj2nd4 465 4 cells cell NNS cord-009571-mygj2nd4 465 5 as as RB cord-009571-mygj2nd4 465 6 well well RB cord-009571-mygj2nd4 465 7 as as IN cord-009571-mygj2nd4 465 8 total total JJ cord-009571-mygj2nd4 465 9 T t NN cord-009571-mygj2nd4 465 10 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 465 11 were be VBD cord-009571-mygj2nd4 465 12 measured measure VBN cord-009571-mygj2nd4 465 13 in in IN cord-009571-mygj2nd4 465 14 19 19 CD cord-009571-mygj2nd4 465 15 patients patient NNS cord-009571-mygj2nd4 465 16 with with IN cord-009571-mygj2nd4 465 17 systemic systemic JJ cord-009571-mygj2nd4 465 18 lupus lupus NN cord-009571-mygj2nd4 465 19 erythematosus erythematosus NN cord-009571-mygj2nd4 465 20 ( ( -LRB- cord-009571-mygj2nd4 465 21 SLE SLE NNP cord-009571-mygj2nd4 465 22 ) ) -RRB- cord-009571-mygj2nd4 465 23 , , , cord-009571-mygj2nd4 465 24 11 11 CD cord-009571-mygj2nd4 465 25 with with IN cord-009571-mygj2nd4 465 26 active active JJ cord-009571-mygj2nd4 465 27 and and CC cord-009571-mygj2nd4 465 28 8 8 CD cord-009571-mygj2nd4 465 29 with with IN cord-009571-mygj2nd4 465 30 inactive inactive JJ cord-009571-mygj2nd4 465 31 disease disease NN cord-009571-mygj2nd4 465 32 , , , cord-009571-mygj2nd4 465 33 and and CC cord-009571-mygj2nd4 465 34 in in IN cord-009571-mygj2nd4 465 35 47 47 CD cord-009571-mygj2nd4 465 36 normal normal JJ cord-009571-mygj2nd4 465 37 subjects subject NNS cord-009571-mygj2nd4 465 38 . . . cord-009571-mygj2nd4 466 1 Mononuclear Mononuclear NNP cord-009571-mygj2nd4 466 2 cells cell NNS cord-009571-mygj2nd4 466 3 were be VBD cord-009571-mygj2nd4 466 4 separated separate VBN cord-009571-mygj2nd4 466 5 on on IN cord-009571-mygj2nd4 466 6 a a DT cord-009571-mygj2nd4 466 7 Ficoll Ficoll NNP cord-009571-mygj2nd4 466 8 - - HYPH cord-009571-mygj2nd4 466 9 Hypaque hypaque JJ cord-009571-mygj2nd4 466 10 gradient gradient NN cord-009571-mygj2nd4 466 11 , , , cord-009571-mygj2nd4 466 12 depleted deplete VBN cord-009571-mygj2nd4 466 13 of of IN cord-009571-mygj2nd4 466 14 adherent adherent JJ cord-009571-mygj2nd4 466 15 and and CC cord-009571-mygj2nd4 466 16 phagocytic phagocytic JJ cord-009571-mygj2nd4 466 17 cells cell NNS cord-009571-mygj2nd4 466 18 , , , cord-009571-mygj2nd4 466 19 and and CC cord-009571-mygj2nd4 466 20 pelleted pellete VBN cord-009571-mygj2nd4 466 21 with with IN cord-009571-mygj2nd4 466 22 neuraminidase neuraminidase RB cord-009571-mygj2nd4 466 23 - - HYPH cord-009571-mygj2nd4 466 24 treated treat VBN cord-009571-mygj2nd4 466 25 sheep sheep NN cord-009571-mygj2nd4 466 26 erythrocytes erythrocyte NNS cord-009571-mygj2nd4 466 27 . . . cord-009571-mygj2nd4 467 1 Rosette rosette NN cord-009571-mygj2nd4 467 2 - - HYPH cord-009571-mygj2nd4 467 3 forming form VBG cord-009571-mygj2nd4 467 4 cells cell NNS cord-009571-mygj2nd4 467 5 were be VBD cord-009571-mygj2nd4 467 6 counted count VBN cord-009571-mygj2nd4 467 7 to to TO cord-009571-mygj2nd4 467 8 determine determine VB cord-009571-mygj2nd4 467 9 the the DT cord-009571-mygj2nd4 467 10 percentage percentage NN cord-009571-mygj2nd4 467 11 of of IN cord-009571-mygj2nd4 467 12 total total JJ cord-009571-mygj2nd4 467 13 T t NN cord-009571-mygj2nd4 467 14 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 467 15 . . . cord-009571-mygj2nd4 468 1 Rosettes rosette NNS cord-009571-mygj2nd4 468 2 were be VBD cord-009571-mygj2nd4 468 3 then then RB cord-009571-mygj2nd4 468 4 mechanically mechanically RB cord-009571-mygj2nd4 468 5 dissociated dissociated JJ cord-009571-mygj2nd4 468 6 and and CC cord-009571-mygj2nd4 468 7 T t NN cord-009571-mygj2nd4 468 8 cells cell NNS cord-009571-mygj2nd4 468 9 separated separate VBN cord-009571-mygj2nd4 468 10 from from IN cord-009571-mygj2nd4 468 11 sheep sheep NN cord-009571-mygj2nd4 468 12 erythrocytes erythrocyte VBZ cord-009571-mygj2nd4 468 13 through through IN cord-009571-mygj2nd4 468 14 a a DT cord-009571-mygj2nd4 468 15 Ficoll Ficoll NNP cord-009571-mygj2nd4 468 16 - - HYPH cord-009571-mygj2nd4 468 17 Hypaque hypaque JJ cord-009571-mygj2nd4 468 18 gradient gradient NN cord-009571-mygj2nd4 468 19 at at IN cord-009571-mygj2nd4 468 20 37 37 CD cord-009571-mygj2nd4 468 21 ° ° NN cord-009571-mygj2nd4 468 22 C c NN cord-009571-mygj2nd4 468 23 . . . cord-009571-mygj2nd4 469 1 Purified purify VBN cord-009571-mygj2nd4 469 2 T t NN cord-009571-mygj2nd4 469 3 cells cell NNS cord-009571-mygj2nd4 469 4 were be VBD cord-009571-mygj2nd4 469 5 pelleted pellete VBN cord-009571-mygj2nd4 469 6 with with IN cord-009571-mygj2nd4 469 7 ox ox JJ cord-009571-mygj2nd4 469 8 erythrocytes erythrocyte NNS cord-009571-mygj2nd4 469 9 sensitized sensitize VBN cord-009571-mygj2nd4 469 10 with with IN cord-009571-mygj2nd4 469 11 rabbit rabbit NN cord-009571-mygj2nd4 469 12 IgG igg NN cord-009571-mygj2nd4 469 13 and and CC cord-009571-mygj2nd4 469 14 rosette rosette NN cord-009571-mygj2nd4 469 15 - - HYPH cord-009571-mygj2nd4 469 16 forming form VBG cord-009571-mygj2nd4 469 17 cells cell NNS cord-009571-mygj2nd4 469 18 recorded record VBN cord-009571-mygj2nd4 469 19 as as IN cord-009571-mygj2nd4 469 20 Ty Ty NNP cord-009571-mygj2nd4 469 21 cells cell NNS cord-009571-mygj2nd4 469 22 . . . cord-009571-mygj2nd4 470 1 A a DT cord-009571-mygj2nd4 470 2 total total NN cord-009571-mygj2nd4 470 3 of of IN cord-009571-mygj2nd4 470 4 200 200 CD cord-009571-mygj2nd4 470 5 cells cell NNS cord-009571-mygj2nd4 470 6 in in IN cord-009571-mygj2nd4 470 7 each each DT cord-009571-mygj2nd4 470 8 of of IN cord-009571-mygj2nd4 470 9 three three CD cord-009571-mygj2nd4 470 10 replicate replicate VBP cord-009571-mygj2nd4 470 11 assays assay NNS cord-009571-mygj2nd4 470 12 was be VBD cord-009571-mygj2nd4 470 13 counted count VBN cord-009571-mygj2nd4 470 14 . . . cord-009571-mygj2nd4 471 1 Active active JJ cord-009571-mygj2nd4 471 2 SLE SLE NNP cord-009571-mygj2nd4 471 3 patients patient NNS cord-009571-mygj2nd4 471 4 showed show VBD cord-009571-mygj2nd4 471 5 a a DT cord-009571-mygj2nd4 471 6 significant significant JJ cord-009571-mygj2nd4 471 7 decrease decrease NN cord-009571-mygj2nd4 471 8 in in IN cord-009571-mygj2nd4 471 9 total total JJ cord-009571-mygj2nd4 471 10 T T NNP cord-009571-mygj2nd4 471 11 lymphocyte lymphocyte NN cord-009571-mygj2nd4 471 12 percentages percentage NNS cord-009571-mygj2nd4 471 13 compared compare VBN cord-009571-mygj2nd4 471 14 to to IN cord-009571-mygj2nd4 471 15 normal normal JJ cord-009571-mygj2nd4 471 16 subjects subject NNS cord-009571-mygj2nd4 471 17 ( ( -LRB- cord-009571-mygj2nd4 471 18 P p NN cord-009571-mygj2nd4 471 19 < < XX cord-009571-mygj2nd4 471 20 0.05 0.05 CD cord-009571-mygj2nd4 471 21 ) ) -RRB- cord-009571-mygj2nd4 471 22 , , , cord-009571-mygj2nd4 471 23 confirming confirm VBG cord-009571-mygj2nd4 471 24 previous previous JJ cord-009571-mygj2nd4 471 25 reports report NNS cord-009571-mygj2nd4 471 26 . . . cord-009571-mygj2nd4 472 1 In in IN cord-009571-mygj2nd4 472 2 addition addition NN cord-009571-mygj2nd4 472 3 , , , cord-009571-mygj2nd4 472 4 markedly markedly RB cord-009571-mygj2nd4 472 5 depressed depressed JJ cord-009571-mygj2nd4 472 6 percentages percentage NNS cord-009571-mygj2nd4 472 7 of of IN cord-009571-mygj2nd4 472 8 Ty ty NN cord-009571-mygj2nd4 472 9 cells cell NNS cord-009571-mygj2nd4 472 10 ( ( -LRB- cord-009571-mygj2nd4 472 11 P p NN cord-009571-mygj2nd4 472 12 < < XX cord-009571-mygj2nd4 472 13 0.002 0.002 CD cord-009571-mygj2nd4 472 14 ) ) -RRB- cord-009571-mygj2nd4 472 15 were be VBD cord-009571-mygj2nd4 472 16 found find VBN cord-009571-mygj2nd4 472 17 in in IN cord-009571-mygj2nd4 472 18 patients patient NNS cord-009571-mygj2nd4 472 19 with with IN cord-009571-mygj2nd4 472 20 active active JJ cord-009571-mygj2nd4 472 21 disease disease NN cord-009571-mygj2nd4 472 22 . . . cord-009571-mygj2nd4 473 1 Patients patient NNS cord-009571-mygj2nd4 473 2 with with IN cord-009571-mygj2nd4 473 3 inactive inactive JJ cord-009571-mygj2nd4 473 4 SLE SLE NNP cord-009571-mygj2nd4 473 5 were be VBD cord-009571-mygj2nd4 473 6 not not RB cord-009571-mygj2nd4 473 7 significantly significantly RB cord-009571-mygj2nd4 473 8 different different JJ cord-009571-mygj2nd4 473 9 from from IN cord-009571-mygj2nd4 473 10 normal normal JJ cord-009571-mygj2nd4 473 11 subjects subject NNS cord-009571-mygj2nd4 473 12 , , , cord-009571-mygj2nd4 473 13 both both CC cord-009571-mygj2nd4 473 14 with with IN cord-009571-mygj2nd4 473 15 regard regard NN cord-009571-mygj2nd4 473 16 to to IN cord-009571-mygj2nd4 473 17 total total JJ cord-009571-mygj2nd4 473 18 T t NN cord-009571-mygj2nd4 473 19 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 473 20 as as RB cord-009571-mygj2nd4 473 21 well well RB cord-009571-mygj2nd4 473 22 as as IN cord-009571-mygj2nd4 473 23 Ty Ty NNP cord-009571-mygj2nd4 473 24 cells cell NNS cord-009571-mygj2nd4 473 25 . . . cord-009571-mygj2nd4 474 1 Two two CD cord-009571-mygj2nd4 474 2 acute acute JJ cord-009571-mygj2nd4 474 3 SLE SLE NNP cord-009571-mygj2nd4 474 4 patients patient NNS cord-009571-mygj2nd4 474 5 who who WP cord-009571-mygj2nd4 474 6 went go VBD cord-009571-mygj2nd4 474 7 into into IN cord-009571-mygj2nd4 474 8 remission remission NN cord-009571-mygj2nd4 474 9 showed show VBD cord-009571-mygj2nd4 474 10 significant significant JJ cord-009571-mygj2nd4 474 11 increases increase NNS cord-009571-mygj2nd4 474 12 in in IN cord-009571-mygj2nd4 474 13 both both DT cord-009571-mygj2nd4 474 14 total total JJ cord-009571-mygj2nd4 474 15 T t NN cord-009571-mygj2nd4 474 16 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 474 17 and and CC cord-009571-mygj2nd4 474 18 Ty ty NN cord-009571-mygj2nd4 474 19 cells cell NNS cord-009571-mygj2nd4 474 20 with with IN cord-009571-mygj2nd4 474 21 clinical clinical JJ cord-009571-mygj2nd4 474 22 and and CC cord-009571-mygj2nd4 474 23 laboratory laboratory NN cord-009571-mygj2nd4 474 24 improvement improvement NN cord-009571-mygj2nd4 474 25 . . . cord-009571-mygj2nd4 475 1 Active active JJ cord-009571-mygj2nd4 475 2 SLE SLE NNP cord-009571-mygj2nd4 475 3 patients patient NNS cord-009571-mygj2nd4 475 4 show show VBP cord-009571-mygj2nd4 475 5 decreases decrease NNS cord-009571-mygj2nd4 475 6 both both DT cord-009571-mygj2nd4 475 7 in in IN cord-009571-mygj2nd4 475 8 total total JJ cord-009571-mygj2nd4 475 9 T t NN cord-009571-mygj2nd4 475 10 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 475 11 and and CC cord-009571-mygj2nd4 475 12 the the DT cord-009571-mygj2nd4 475 13 Ty Ty NNP cord-009571-mygj2nd4 475 14 subset subset NN cord-009571-mygj2nd4 475 15 of of IN cord-009571-mygj2nd4 475 16 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 475 17 associated associate VBN cord-009571-mygj2nd4 475 18 with with IN cord-009571-mygj2nd4 475 19 suppressor suppressor NN cord-009571-mygj2nd4 475 20 activity activity NN cord-009571-mygj2nd4 475 21 . . . cord-009571-mygj2nd4 476 1 Low low JJ cord-009571-mygj2nd4 476 2 levels level NNS cord-009571-mygj2nd4 476 3 of of IN cord-009571-mygj2nd4 476 4 detectable detectable JJ cord-009571-mygj2nd4 476 5 Ty Ty NNP cord-009571-mygj2nd4 476 6 cells cell NNS cord-009571-mygj2nd4 476 7 in in IN cord-009571-mygj2nd4 476 8 SLE SLE NNP cord-009571-mygj2nd4 476 9 may may MD cord-009571-mygj2nd4 476 10 reflect reflect VB cord-009571-mygj2nd4 476 11 the the DT cord-009571-mygj2nd4 476 12 presence presence NN cord-009571-mygj2nd4 476 13 of of IN cord-009571-mygj2nd4 476 14 high high JJ cord-009571-mygj2nd4 476 15 levels level NNS cord-009571-mygj2nd4 476 16 of of IN cord-009571-mygj2nd4 476 17 circulating circulate VBG cord-009571-mygj2nd4 476 18 immune immune JJ cord-009571-mygj2nd4 476 19 complexes complex NNS cord-009571-mygj2nd4 476 20 and/or and/or CC cord-009571-mygj2nd4 476 21 the the DT cord-009571-mygj2nd4 476 22 defect defect NN cord-009571-mygj2nd4 476 23 in in IN cord-009571-mygj2nd4 476 24 suppressor suppressor NN cord-009571-mygj2nd4 476 25 activity activity NN cord-009571-mygj2nd4 476 26 reported report VBN cord-009571-mygj2nd4 476 27 in in IN cord-009571-mygj2nd4 476 28 these these DT cord-009571-mygj2nd4 476 29 patients patient NNS cord-009571-mygj2nd4 476 30 . . . cord-009571-mygj2nd4 477 1 The the DT cord-009571-mygj2nd4 477 2 6 6 CD cord-009571-mygj2nd4 477 3 - - SYM cord-009571-mygj2nd4 477 4 8 8 CD cord-009571-mygj2nd4 477 5 fold fold JJ cord-009571-mygj2nd4 477 6 increase increase NN cord-009571-mygj2nd4 477 7 in in IN cord-009571-mygj2nd4 477 8 red red JJ cord-009571-mygj2nd4 477 9 cell cell NN cord-009571-mygj2nd4 477 10 turnover turnover NN cord-009571-mygj2nd4 477 11 in in IN cord-009571-mygj2nd4 477 12 patients patient NNS cord-009571-mygj2nd4 477 13 with with IN cord-009571-mygj2nd4 477 14 sickle sickle NN cord-009571-mygj2nd4 477 15 cell cell NN cord-009571-mygj2nd4 477 16 anemia anemia NN cord-009571-mygj2nd4 477 17 results result VBZ cord-009571-mygj2nd4 477 18 in in IN cord-009571-mygj2nd4 477 19 uric uric JJ cord-009571-mygj2nd4 477 20 acid acid NN cord-009571-mygj2nd4 477 21 overproduction overproduction NN cord-009571-mygj2nd4 477 22 . . . cord-009571-mygj2nd4 478 1 Since since IN cord-009571-mygj2nd4 478 2 uric uric JJ cord-009571-mygj2nd4 478 3 acid acid NN cord-009571-mygj2nd4 478 4 overproduction overproduction NN cord-009571-mygj2nd4 478 5 in in IN cord-009571-mygj2nd4 478 6 these these DT cord-009571-mygj2nd4 478 7 patients patient NNS cord-009571-mygj2nd4 478 8 begins begin VBZ cord-009571-mygj2nd4 478 9 within within IN cord-009571-mygj2nd4 478 10 the the DT cord-009571-mygj2nd4 478 11 first first JJ cord-009571-mygj2nd4 478 12 5 5 CD cord-009571-mygj2nd4 478 13 years year NNS cord-009571-mygj2nd4 478 14 of of IN cord-009571-mygj2nd4 478 15 life life NN cord-009571-mygj2nd4 478 16 , , , cord-009571-mygj2nd4 478 17 we -PRON- PRP cord-009571-mygj2nd4 478 18 studied study VBD cord-009571-mygj2nd4 478 19 91 91 CD cord-009571-mygj2nd4 478 20 patients patient NNS cord-009571-mygj2nd4 478 21 with with IN cord-009571-mygj2nd4 478 22 sickle sickle NN cord-009571-mygj2nd4 478 23 cell cell NN cord-009571-mygj2nd4 478 24 anemia anemia NN cord-009571-mygj2nd4 478 25 and and CC cord-009571-mygj2nd4 478 26 normal normal JJ cord-009571-mygj2nd4 478 27 GFR GFR NNP cord-009571-mygj2nd4 478 28 ranging range VBG cord-009571-mygj2nd4 478 29 in in IN cord-009571-mygj2nd4 478 30 age age NN cord-009571-mygj2nd4 478 31 from from IN cord-009571-mygj2nd4 478 32 6 6 CD cord-009571-mygj2nd4 478 33 to to IN cord-009571-mygj2nd4 478 34 48 48 CD cord-009571-mygj2nd4 478 35 to to TO cord-009571-mygj2nd4 478 36 determine determine VB cord-009571-mygj2nd4 478 37 the the DT cord-009571-mygj2nd4 478 38 natural natural JJ cord-009571-mygj2nd4 478 39 history history NN cord-009571-mygj2nd4 478 40 of of IN cord-009571-mygj2nd4 478 41 serum serum NN cord-009571-mygj2nd4 478 42 uric uric NN cord-009571-mygj2nd4 478 43 acid acid NN cord-009571-mygj2nd4 478 44 and and CC cord-009571-mygj2nd4 478 45 urate urate NN cord-009571-mygj2nd4 478 46 excretion excretion NN cord-009571-mygj2nd4 478 47 in in IN cord-009571-mygj2nd4 478 48 sickle sickle NN cord-009571-mygj2nd4 478 49 cell cell NN cord-009571-mygj2nd4 478 50 disease disease NN cord-009571-mygj2nd4 478 51 . . . cord-009571-mygj2nd4 479 1 Hyperuricemia Hyperuricemia NNP cord-009571-mygj2nd4 479 2 ( ( -LRB- cord-009571-mygj2nd4 479 3 plasma plasma NN cord-009571-mygj2nd4 479 4 urate urate NN cord-009571-mygj2nd4 479 5 6.5 6.5 CD cord-009571-mygj2nd4 479 6 mg mg NNP cord-009571-mygj2nd4 479 7 / / SYM cord-009571-mygj2nd4 479 8 dl dl NNP cord-009571-mygj2nd4 479 9 ) ) -RRB- cord-009571-mygj2nd4 479 10 was be VBD cord-009571-mygj2nd4 479 11 observed observe VBN cord-009571-mygj2nd4 479 12 in in IN cord-009571-mygj2nd4 479 13 only only RB cord-009571-mygj2nd4 479 14 2 2 CD cord-009571-mygj2nd4 479 15 of of IN cord-009571-mygj2nd4 479 16 26 26 CD cord-009571-mygj2nd4 479 17 patients patient NNS cord-009571-mygj2nd4 479 18 younger young JJR cord-009571-mygj2nd4 479 19 than than IN cord-009571-mygj2nd4 479 20 age age NN cord-009571-mygj2nd4 479 21 13 13 CD cord-009571-mygj2nd4 479 22 . . . cord-009571-mygj2nd4 480 1 However however RB cord-009571-mygj2nd4 480 2 , , , cord-009571-mygj2nd4 480 3 urinary urinary JJ cord-009571-mygj2nd4 480 4 uric uric NN cord-009571-mygj2nd4 480 5 acid acid NN cord-009571-mygj2nd4 480 6 / / SYM cord-009571-mygj2nd4 480 7 creatinine creatinine NN cord-009571-mygj2nd4 480 8 ratios ratio NNS cord-009571-mygj2nd4 480 9 and and CC cord-009571-mygj2nd4 480 10 24 24 CD cord-009571-mygj2nd4 480 11 hour hour NN cord-009571-mygj2nd4 480 12 urinary urinary JJ cord-009571-mygj2nd4 480 13 uric uric NN cord-009571-mygj2nd4 480 14 acid acid NN cord-009571-mygj2nd4 480 15 levels level NNS cord-009571-mygj2nd4 480 16 were be VBD cord-009571-mygj2nd4 480 17 elevated elevate VBN cord-009571-mygj2nd4 480 18 in in IN cord-009571-mygj2nd4 480 19 these these DT cord-009571-mygj2nd4 480 20 patients patient NNS cord-009571-mygj2nd4 480 21 , , , cord-009571-mygj2nd4 480 22 indicating indicate VBG cord-009571-mygj2nd4 480 23 uric uric NN cord-009571-mygj2nd4 480 24 acid acid NN cord-009571-mygj2nd4 480 25 over over IN cord-009571-mygj2nd4 480 26 - - HYPH cord-009571-mygj2nd4 480 27 production production NN cord-009571-mygj2nd4 480 28 and and CC cord-009571-mygj2nd4 480 29 hyperuricosuria hyperuricosuria NN cord-009571-mygj2nd4 480 30 . . . cord-009571-mygj2nd4 481 1 Thirty thirty CD cord-009571-mygj2nd4 481 2 - - HYPH cord-009571-mygj2nd4 481 3 seven seven CD cord-009571-mygj2nd4 481 4 percent percent NN cord-009571-mygj2nd4 481 5 of of IN cord-009571-mygj2nd4 481 6 adults adult NNS cord-009571-mygj2nd4 481 7 ( ( -LRB- cord-009571-mygj2nd4 481 8 24/65 24/65 CD cord-009571-mygj2nd4 481 9 ) ) -RRB- cord-009571-mygj2nd4 481 10 were be VBD cord-009571-mygj2nd4 481 11 hyperuricemic hyperuricemic JJ cord-009571-mygj2nd4 481 12 ( ( -LRB- cord-009571-mygj2nd4 481 13 mean mean JJ cord-009571-mygj2nd4 481 14 plasma plasma NN cord-009571-mygj2nd4 481 15 urate urate NN cord-009571-mygj2nd4 481 16 8.6 8.6 CD cord-009571-mygj2nd4 481 17 f f NNP cord-009571-mygj2nd4 481 18 0.5 0.5 CD cord-009571-mygj2nd4 481 19 mg mg NNP cord-009571-mygj2nd4 481 20 / / SYM cord-009571-mygj2nd4 481 21 dl dl NNP cord-009571-mygj2nd4 481 22 ) ) -RRB- cord-009571-mygj2nd4 481 23 ; ; : cord-009571-mygj2nd4 481 24 41 41 CD cord-009571-mygj2nd4 481 25 were be VBD cord-009571-mygj2nd4 481 26 normouricemic normouricemic JJ cord-009571-mygj2nd4 481 27 . . . cord-009571-mygj2nd4 482 1 Of of IN cord-009571-mygj2nd4 482 2 normouricemic normouricemic JJ cord-009571-mygj2nd4 482 3 adults adult NNS cord-009571-mygj2nd4 482 4 studied study VBD cord-009571-mygj2nd4 482 5 while while IN cord-009571-mygj2nd4 482 6 on on IN cord-009571-mygj2nd4 482 7 a a DT cord-009571-mygj2nd4 482 8 purine purine NN cord-009571-mygj2nd4 482 9 - - HYPH cord-009571-mygj2nd4 482 10 free free JJ cord-009571-mygj2nd4 482 11 diet diet NN cord-009571-mygj2nd4 482 12 , , , cord-009571-mygj2nd4 482 13 9 9 CD cord-009571-mygj2nd4 482 14 of of IN cord-009571-mygj2nd4 482 15 16 16 CD cord-009571-mygj2nd4 482 16 ( ( -LRB- cord-009571-mygj2nd4 482 17 56 56 CD cord-009571-mygj2nd4 482 18 % % NN cord-009571-mygj2nd4 482 19 ) ) -RRB- cord-009571-mygj2nd4 482 20 had have VBD cord-009571-mygj2nd4 482 21 24 24 CD cord-009571-mygj2nd4 482 22 hour hour NN cord-009571-mygj2nd4 482 23 urine urine NN cord-009571-mygj2nd4 482 24 uric uric NN cord-009571-mygj2nd4 482 25 acid acid NN cord-009571-mygj2nd4 482 26 excretion excretion NN cord-009571-mygj2nd4 482 27 greater great JJR cord-009571-mygj2nd4 482 28 than than IN cord-009571-mygj2nd4 482 29 600 600 CD cord-009571-mygj2nd4 482 30 mg mg NN cord-009571-mygj2nd4 482 31 . . . cord-009571-mygj2nd4 483 1 Urate urate JJ cord-009571-mygj2nd4 483 2 clearance clearance NN cord-009571-mygj2nd4 483 3 in in IN cord-009571-mygj2nd4 483 4 these these DT cord-009571-mygj2nd4 483 5 9 9 CD cord-009571-mygj2nd4 483 6 patients patient NNS cord-009571-mygj2nd4 483 7 was be VBD cord-009571-mygj2nd4 483 8 increased increase VBN cord-009571-mygj2nd4 483 9 ( ( -LRB- cord-009571-mygj2nd4 483 10 Cur cur JJ cord-009571-mygj2nd4 483 11 14.8 14.8 CD cord-009571-mygj2nd4 483 12 f f NN cord-009571-mygj2nd4 483 13 0.8 0.8 CD cord-009571-mygj2nd4 483 14 ml ml NN cord-009571-mygj2nd4 483 15 / / SYM cord-009571-mygj2nd4 483 16 min min NNP cord-009571-mygj2nd4 483 17 ) ) -RRB- cord-009571-mygj2nd4 483 18 , , , cord-009571-mygj2nd4 483 19 indicating indicate VBG cord-009571-mygj2nd4 483 20 that that IN cord-009571-mygj2nd4 483 21 normouricemia normouricemia NN cord-009571-mygj2nd4 483 22 was be VBD cord-009571-mygj2nd4 483 23 maintained maintain VBN cord-009571-mygj2nd4 483 24 by by IN cord-009571-mygj2nd4 483 25 hyperuricosuria hyperuricosuria NNP cord-009571-mygj2nd4 483 26 . . . cord-009571-mygj2nd4 484 1 Urate urate JJ cord-009571-mygj2nd4 484 2 clearance clearance NN cord-009571-mygj2nd4 484 3 in in IN cord-009571-mygj2nd4 484 4 the the DT cord-009571-mygj2nd4 484 5 hyperuricemic hyperuricemic JJ cord-009571-mygj2nd4 484 6 subjects subject NNS cord-009571-mygj2nd4 484 7 was be VBD cord-009571-mygj2nd4 484 8 decreased decrease VBN cord-009571-mygj2nd4 484 9 ( ( -LRB- cord-009571-mygj2nd4 484 10 Cur Cur NNP cord-009571-mygj2nd4 484 11 5.3 5.3 CD cord-009571-mygj2nd4 484 12 f f NN cord-009571-mygj2nd4 484 13 0.8 0.8 CD cord-009571-mygj2nd4 484 14 ml ml NN cord-009571-mygj2nd4 484 15 / / SYM cord-009571-mygj2nd4 484 16 min min NNP cord-009571-mygj2nd4 484 17 ) ) -RRB- cord-009571-mygj2nd4 484 18 as as IN cord-009571-mygj2nd4 484 19 compared compare VBN cord-009571-mygj2nd4 484 20 to to IN cord-009571-mygj2nd4 484 21 both both DT cord-009571-mygj2nd4 484 22 normal normal JJ cord-009571-mygj2nd4 484 23 subjects subject NNS cord-009571-mygj2nd4 484 24 ( ( -LRB- cord-009571-mygj2nd4 484 25 Cur Cur NNP cord-009571-mygj2nd4 484 26 8.2 8.2 CD cord-009571-mygj2nd4 484 27 f f NN cord-009571-mygj2nd4 484 28 0.6 0.6 CD cord-009571-mygj2nd4 484 29 ml ml NN cord-009571-mygj2nd4 484 30 / / SYM cord-009571-mygj2nd4 484 31 min min NNP cord-009571-mygj2nd4 484 32 ) ) -RRB- cord-009571-mygj2nd4 484 33 and and CC cord-009571-mygj2nd4 484 34 normouricemic normouricemic JJ cord-009571-mygj2nd4 484 35 adults adult NNS cord-009571-mygj2nd4 484 36 with with IN cord-009571-mygj2nd4 484 37 sickle sickle NN cord-009571-mygj2nd4 484 38 cell cell NN cord-009571-mygj2nd4 484 39 disease disease NN cord-009571-mygj2nd4 484 40 ( ( -LRB- cord-009571-mygj2nd4 484 41 Cur cur JJ cord-009571-mygj2nd4 484 42 14.8 14.8 CD cord-009571-mygj2nd4 484 43 f f NNP cord-009571-mygj2nd4 484 44 0.8 0.8 CD cord-009571-mygj2nd4 484 45 ml ml NN cord-009571-mygj2nd4 484 46 / / SYM cord-009571-mygj2nd4 484 47 min min NN cord-009571-mygj2nd4 484 48 ) ) -RRB- cord-009571-mygj2nd4 484 49 . . . cord-009571-mygj2nd4 485 1 Urate urate JJ cord-009571-mygj2nd4 485 2 clear clear JJ cord-009571-mygj2nd4 485 3 - - HYPH cord-009571-mygj2nd4 485 4 ance ance NN cord-009571-mygj2nd4 485 5 appears appear VBZ cord-009571-mygj2nd4 485 6 to to TO cord-009571-mygj2nd4 485 7 be be VB cord-009571-mygj2nd4 485 8 the the DT cord-009571-mygj2nd4 485 9 major major JJ cord-009571-mygj2nd4 485 10 determinant determinant NN cord-009571-mygj2nd4 485 11 of of IN cord-009571-mygj2nd4 485 12 serum serum NN cord-009571-mygj2nd4 485 13 uric uric NN cord-009571-mygj2nd4 485 14 acid acid NN cord-009571-mygj2nd4 485 15 concentration concentration NN cord-009571-mygj2nd4 485 16 even even RB cord-009571-mygj2nd4 485 17 in in IN cord-009571-mygj2nd4 485 18 sickle sickle NN cord-009571-mygj2nd4 485 19 cell cell NN cord-009571-mygj2nd4 485 20 patients patient NNS cord-009571-mygj2nd4 485 21 with with IN cord-009571-mygj2nd4 485 22 urate urate NN cord-009571-mygj2nd4 485 23 overproduction overproduction NN cord-009571-mygj2nd4 485 24 . . . cord-009571-mygj2nd4 486 1 Responses response NNS cord-009571-mygj2nd4 486 2 of of IN cord-009571-mygj2nd4 486 3 urate urate NN cord-009571-mygj2nd4 486 4 clearance clearance NN cord-009571-mygj2nd4 486 5 to to IN cord-009571-mygj2nd4 486 6 probenecid probenecid NN cord-009571-mygj2nd4 486 7 and and CC cord-009571-mygj2nd4 486 8 pyrazinamide pyrazinamide NN cord-009571-mygj2nd4 486 9 were be VBD cord-009571-mygj2nd4 486 10 exaggerated exaggerate VBN cord-009571-mygj2nd4 486 11 in in IN cord-009571-mygj2nd4 486 12 the the DT cord-009571-mygj2nd4 486 13 normouricemic normouricemic JJ cord-009571-mygj2nd4 486 14 overexcretors overexcretor NNS cord-009571-mygj2nd4 486 15 [ [ -LRB- cord-009571-mygj2nd4 486 16 PZA PZA NNP cord-009571-mygj2nd4 486 17 suppressible suppressible JJ cord-009571-mygj2nd4 486 18 urate urate NN cord-009571-mygj2nd4 486 19 clearance clearance NN cord-009571-mygj2nd4 486 20 ( ( -LRB- cord-009571-mygj2nd4 486 21 PSur):SS PSur):SS NNP cord-009571-mygj2nd4 486 22 , , , cord-009571-mygj2nd4 486 23 12.6 12.6 CD cord-009571-mygj2nd4 486 24 f f NNP cord-009571-mygj2nd4 486 25 0.8 0.8 CD cord-009571-mygj2nd4 486 26 ml ml NN cord-009571-mygj2nd4 486 27 / / SYM cord-009571-mygj2nd4 486 28 min min NN cord-009571-mygj2nd4 486 29 ; ; : cord-009571-mygj2nd4 486 30 control control NN cord-009571-mygj2nd4 486 31 6.4 6.4 CD cord-009571-mygj2nd4 486 32 f f NN cord-009571-mygj2nd4 486 33 0.8 0.8 CD cord-009571-mygj2nd4 486 34 ml ml NN cord-009571-mygj2nd4 486 35 / / SYM cord-009571-mygj2nd4 486 36 min min NN cord-009571-mygj2nd4 486 37 ; ; : cord-009571-mygj2nd4 486 38 probenecid probenecid JJ cord-009571-mygj2nd4 486 39 ( ( -LRB- cord-009571-mygj2nd4 486 40 PB PB NNP cord-009571-mygj2nd4 486 41 ) ) -RRB- cord-009571-mygj2nd4 486 42 response response NN cord-009571-mygj2nd4 486 43 ; ; : cord-009571-mygj2nd4 486 44 SS SS NNP cord-009571-mygj2nd4 486 45 , , , cord-009571-mygj2nd4 486 46 48.8 48.8 CD cord-009571-mygj2nd4 486 47 f f NN cord-009571-mygj2nd4 486 48 9 9 CD cord-009571-mygj2nd4 486 49 ml ml NN cord-009571-mygj2nd4 486 50 / / SYM cord-009571-mygj2nd4 486 51 min min NN cord-009571-mygj2nd4 486 52 ; ; : cord-009571-mygj2nd4 486 53 control control NN cord-009571-mygj2nd4 486 54 , , , cord-009571-mygj2nd4 486 55 40.4 40.4 CD cord-009571-mygj2nd4 486 56 f f NN cord-009571-mygj2nd4 486 57 8.0 8.0 CD cord-009571-mygj2nd4 486 58 mI mI NNP cord-009571-mygj2nd4 486 59 / / SYM cord-009571-mygj2nd4 486 60 min min NN cord-009571-mygj2nd4 486 61 ] ] -RRB- cord-009571-mygj2nd4 486 62 and and CC cord-009571-mygj2nd4 486 63 were be VBD cord-009571-mygj2nd4 486 64 diminished diminish VBN cord-009571-mygj2nd4 486 65 in in IN cord-009571-mygj2nd4 486 66 the the DT cord-009571-mygj2nd4 486 67 hyperuricemic hyperuricemic JJ cord-009571-mygj2nd4 486 68 subjects subject NNS cord-009571-mygj2nd4 486 69 with with IN cord-009571-mygj2nd4 486 70 diminished diminished JJ cord-009571-mygj2nd4 486 71 urate urate NN cord-009571-mygj2nd4 486 72 clearance clearance NN cord-009571-mygj2nd4 486 73 ( ( -LRB- cord-009571-mygj2nd4 486 74 PSur PSur NNP cord-009571-mygj2nd4 486 75 , , , cord-009571-mygj2nd4 486 76 4.9 4.9 CD cord-009571-mygj2nd4 486 77 f f CD cord-009571-mygj2nd4 486 78 1.2 1.2 CD cord-009571-mygj2nd4 486 79 ml ml NN cord-009571-mygj2nd4 486 80 / / SYM cord-009571-mygj2nd4 486 81 min min NN cord-009571-mygj2nd4 486 82 ; ; : cord-009571-mygj2nd4 486 83 PB PB NNP cord-009571-mygj2nd4 486 84 response response NN cord-009571-mygj2nd4 486 85 , , , cord-009571-mygj2nd4 486 86 15 15 CD cord-009571-mygj2nd4 486 87 f f CD cord-009571-mygj2nd4 486 88 2.2 2.2 CD cord-009571-mygj2nd4 486 89 ml ml NN cord-009571-mygj2nd4 486 90 / / SYM cord-009571-mygj2nd4 486 91 min min NN cord-009571-mygj2nd4 486 92 ) ) -RRB- cord-009571-mygj2nd4 486 93 . . . cord-009571-mygj2nd4 487 1 Urate urate JJ cord-009571-mygj2nd4 487 2 clearance clearance NN cord-009571-mygj2nd4 487 3 was be VBD cord-009571-mygj2nd4 487 4 correlated correlate VBN cord-009571-mygj2nd4 487 5 PAH PAH NNP cord-009571-mygj2nd4 487 6 clearance clearance NN cord-009571-mygj2nd4 487 7 . . . cord-009571-mygj2nd4 488 1 These these DT cord-009571-mygj2nd4 488 2 results result NNS cord-009571-mygj2nd4 488 3 suggest suggest VBP cord-009571-mygj2nd4 488 4 that that IN cord-009571-mygj2nd4 488 5 changes change NNS cord-009571-mygj2nd4 488 6 in in IN cord-009571-mygj2nd4 488 7 urate urate NN cord-009571-mygj2nd4 488 8 clearance clearance NN cord-009571-mygj2nd4 488 9 were be VBD cord-009571-mygj2nd4 488 10 secondary secondary JJ cord-009571-mygj2nd4 488 11 to to IN cord-009571-mygj2nd4 488 12 changes change NNS cord-009571-mygj2nd4 488 13 in in IN cord-009571-mygj2nd4 488 14 tubular tubular JJ cord-009571-mygj2nd4 488 15 secretion secretion NN cord-009571-mygj2nd4 488 16 in in IN cord-009571-mygj2nd4 488 17 urate urate NN cord-009571-mygj2nd4 488 18 . . . cord-009571-mygj2nd4 489 1 The the DT cord-009571-mygj2nd4 489 2 initial initial JJ cord-009571-mygj2nd4 489 3 response response NN cord-009571-mygj2nd4 489 4 to to IN cord-009571-mygj2nd4 489 5 urate urate NN cord-009571-mygj2nd4 489 6 overproduction overproduction NN cord-009571-mygj2nd4 489 7 in in IN cord-009571-mygj2nd4 489 8 SS SS NNP cord-009571-mygj2nd4 489 9 disease disease NN cord-009571-mygj2nd4 489 10 is be VBZ cord-009571-mygj2nd4 489 11 hyperuricosuria hyperuricosuria NN cord-009571-mygj2nd4 489 12 with with IN cord-009571-mygj2nd4 489 13 increased increase VBN cord-009571-mygj2nd4 489 14 urate urate NN cord-009571-mygj2nd4 489 15 clearance clearance NN cord-009571-mygj2nd4 489 16 and and CC cord-009571-mygj2nd4 489 17 maintenance maintenance NN cord-009571-mygj2nd4 489 18 of of IN cord-009571-mygj2nd4 489 19 normal normal JJ cord-009571-mygj2nd4 489 20 serum serum NN cord-009571-mygj2nd4 489 21 urate urate NN cord-009571-mygj2nd4 489 22 concentration concentration NN cord-009571-mygj2nd4 489 23 . . . cord-009571-mygj2nd4 490 1 Hyperuricemia Hyperuricemia NNP cord-009571-mygj2nd4 490 2 is be VBZ cord-009571-mygj2nd4 490 3 found find VBN cord-009571-mygj2nd4 490 4 in in IN cord-009571-mygj2nd4 490 5 adults adult NNS cord-009571-mygj2nd4 490 6 with with IN cord-009571-mygj2nd4 490 7 diminished diminished JJ cord-009571-mygj2nd4 490 8 urate urate NN cord-009571-mygj2nd4 490 9 clearance clearance NN cord-009571-mygj2nd4 490 10 and and CC cord-009571-mygj2nd4 490 11 is be VBZ cord-009571-mygj2nd4 490 12 associated associate VBN cord-009571-mygj2nd4 490 13 with with IN cord-009571-mygj2nd4 490 14 other other JJ cord-009571-mygj2nd4 490 15 evidence evidence NN cord-009571-mygj2nd4 490 16 of of IN cord-009571-mygj2nd4 490 17 impaired impaired JJ cord-009571-mygj2nd4 490 18 renal renal JJ cord-009571-mygj2nd4 490 19 tubular tubular JJ cord-009571-mygj2nd4 490 20 function function NN cord-009571-mygj2nd4 490 21 . . . cord-009571-mygj2nd4 491 1 Nephropathy Nephropathy NNP cord-009571-mygj2nd4 491 2 is be VBZ cord-009571-mygj2nd4 491 3 a a DT cord-009571-mygj2nd4 491 4 little little JJ cord-009571-mygj2nd4 491 5 known know VBN cord-009571-mygj2nd4 491 6 complication complication NN cord-009571-mygj2nd4 491 7 of of IN cord-009571-mygj2nd4 491 8 polymyositis polymyositis NNP cord-009571-mygj2nd4 491 9 . . . cord-009571-mygj2nd4 492 1 Thus thus RB cord-009571-mygj2nd4 492 2 , , , cord-009571-mygj2nd4 492 3 we -PRON- PRP cord-009571-mygj2nd4 492 4 describe describe VBP cord-009571-mygj2nd4 492 5 the the DT cord-009571-mygj2nd4 492 6 features feature NNS cord-009571-mygj2nd4 492 7 of of IN cord-009571-mygj2nd4 492 8 glomerulonephritis glomerulonephritis NN cord-009571-mygj2nd4 492 9 in in IN cord-009571-mygj2nd4 492 10 5 5 CD cord-009571-mygj2nd4 492 11 patients patient NNS cord-009571-mygj2nd4 492 12 with with IN cord-009571-mygj2nd4 492 13 polymyositis polymyositis NN cord-009571-mygj2nd4 492 14 . . . cord-009571-mygj2nd4 493 1 The the DT cord-009571-mygj2nd4 493 2 patients patient NNS cord-009571-mygj2nd4 493 3 ( ( -LRB- cord-009571-mygj2nd4 493 4 4 4 CD cord-009571-mygj2nd4 493 5 men man NNS cord-009571-mygj2nd4 493 6 and and CC cord-009571-mygj2nd4 493 7 1 1 CD cord-009571-mygj2nd4 493 8 woman woman NN cord-009571-mygj2nd4 493 9 ) ) -RRB- cord-009571-mygj2nd4 493 10 aged age VBN cord-009571-mygj2nd4 493 11 21 21 CD cord-009571-mygj2nd4 493 12 - - SYM cord-009571-mygj2nd4 493 13 41 41 CD cord-009571-mygj2nd4 493 14 years year NNS cord-009571-mygj2nd4 494 1 each each DT cord-009571-mygj2nd4 494 2 presented present VBN cord-009571-mygj2nd4 494 3 with with IN cord-009571-mygj2nd4 494 4 symmetrical symmetrical JJ cord-009571-mygj2nd4 494 5 limb limb NN cord-009571-mygj2nd4 494 6 girdle girdle NN cord-009571-mygj2nd4 494 7 weakness weakness NN cord-009571-mygj2nd4 494 8 , , , cord-009571-mygj2nd4 494 9 widespread widespread JJ cord-009571-mygj2nd4 494 10 polyarthritis polyarthritis NN cord-009571-mygj2nd4 494 11 , , , cord-009571-mygj2nd4 494 12 myalgias myalgias NNP cord-009571-mygj2nd4 494 13 , , , cord-009571-mygj2nd4 494 14 recurrent recurrent JJ cord-009571-mygj2nd4 494 15 fever fever NN cord-009571-mygj2nd4 494 16 , , , cord-009571-mygj2nd4 494 17 and and CC cord-009571-mygj2nd4 494 18 proteinuria proteinuria NN cord-009571-mygj2nd4 494 19 . . . cord-009571-mygj2nd4 495 1 CPK CPK NNP cord-009571-mygj2nd4 495 2 , , , cord-009571-mygj2nd4 495 3 LDH LDH NNP cord-009571-mygj2nd4 495 4 , , , cord-009571-mygj2nd4 495 5 and and CC cord-009571-mygj2nd4 495 6 SGOT SGOT NNP cord-009571-mygj2nd4 495 7 levels level NNS cord-009571-mygj2nd4 495 8 were be VBD cord-009571-mygj2nd4 495 9 elevated elevate VBN cord-009571-mygj2nd4 495 10 in in IN cord-009571-mygj2nd4 495 11 all all DT cord-009571-mygj2nd4 495 12 cases case NNS cord-009571-mygj2nd4 495 13 , , , cord-009571-mygj2nd4 495 14 and and CC cord-009571-mygj2nd4 495 15 the the DT cord-009571-mygj2nd4 495 16 diagnosis diagnosis NN cord-009571-mygj2nd4 495 17 of of IN cord-009571-mygj2nd4 495 18 polymyositis polymyositis NNP cord-009571-mygj2nd4 495 19 was be VBD cord-009571-mygj2nd4 495 20 confirmed confirm VBN cord-009571-mygj2nd4 495 21 by by IN cord-009571-mygj2nd4 495 22 electromyography electromyography NN cord-009571-mygj2nd4 495 23 and and CC cord-009571-mygj2nd4 495 24 muscle muscle NN cord-009571-mygj2nd4 495 25 biopsy biopsy NN cord-009571-mygj2nd4 495 26 . . . cord-009571-mygj2nd4 496 1 Although although IN cord-009571-mygj2nd4 496 2 Raynaud Raynaud NNP cord-009571-mygj2nd4 496 3 's 's POS cord-009571-mygj2nd4 496 4 phenomenon phenomenon NN cord-009571-mygj2nd4 496 5 and and CC cord-009571-mygj2nd4 496 6 sacroiliitis sacroiliitis NNP cord-009571-mygj2nd4 496 7 were be VBD cord-009571-mygj2nd4 496 8 each each DT cord-009571-mygj2nd4 496 9 present present JJ cord-009571-mygj2nd4 496 10 in in IN cord-009571-mygj2nd4 496 11 one one CD cord-009571-mygj2nd4 496 12 case case NN cord-009571-mygj2nd4 496 13 , , , cord-009571-mygj2nd4 496 14 no no DT cord-009571-mygj2nd4 496 15 patient patient NN cord-009571-mygj2nd4 496 16 had have VBD cord-009571-mygj2nd4 496 17 the the DT cord-009571-mygj2nd4 496 18 skin skin NN cord-009571-mygj2nd4 496 19 changes change NNS cord-009571-mygj2nd4 496 20 of of IN cord-009571-mygj2nd4 496 21 dermatomyositis dermatomyositis NN cord-009571-mygj2nd4 496 22 , , , cord-009571-mygj2nd4 496 23 and and CC cord-009571-mygj2nd4 496 24 no no DT cord-009571-mygj2nd4 496 25 evidence evidence NN cord-009571-mygj2nd4 496 26 of of IN cord-009571-mygj2nd4 496 27 other other JJ cord-009571-mygj2nd4 496 28 diffuse diffuse JJ cord-009571-mygj2nd4 496 29 connective connective JJ cord-009571-mygj2nd4 496 30 tissue tissue NN cord-009571-mygj2nd4 496 31 disease disease NN cord-009571-mygj2nd4 496 32 or or CC cord-009571-mygj2nd4 496 33 underlying underlying JJ cord-009571-mygj2nd4 496 34 neoplasm neoplasm NN cord-009571-mygj2nd4 496 35 . . . cord-009571-mygj2nd4 497 1 ANA ANA NNP cord-009571-mygj2nd4 497 2 was be VBD cord-009571-mygj2nd4 497 3 negative negative JJ cord-009571-mygj2nd4 497 4 in in IN cord-009571-mygj2nd4 497 5 all all DT cord-009571-mygj2nd4 497 6 patients patient NNS cord-009571-mygj2nd4 497 7 ; ; : cord-009571-mygj2nd4 497 8 cryoglobulins cryoglobulins NNP cord-009571-mygj2nd4 497 9 , , , cord-009571-mygj2nd4 497 10 LE LE NNP cord-009571-mygj2nd4 497 11 preparations preparation NNS cord-009571-mygj2nd4 497 12 , , , cord-009571-mygj2nd4 497 13 and and CC cord-009571-mygj2nd4 497 14 ASOT ASOT NNP cord-009571-mygj2nd4 497 15 were be VBD cord-009571-mygj2nd4 497 16 absent absent JJ cord-009571-mygj2nd4 497 17 in in IN cord-009571-mygj2nd4 497 18 4 4 CD cord-009571-mygj2nd4 497 19 patients patient NNS cord-009571-mygj2nd4 497 20 tested test VBN cord-009571-mygj2nd4 497 21 . . . cord-009571-mygj2nd4 498 1 C3 c3 NN cord-009571-mygj2nd4 498 2 complement complement NN cord-009571-mygj2nd4 498 3 level level NN cord-009571-mygj2nd4 498 4 was be VBD cord-009571-mygj2nd4 498 5 decreased decrease VBN cord-009571-mygj2nd4 498 6 in in IN cord-009571-mygj2nd4 498 7 one one CD cord-009571-mygj2nd4 498 8 case case NN cord-009571-mygj2nd4 498 9 . . . cord-009571-mygj2nd4 499 1 Rheumatoid rheumatoid NN cord-009571-mygj2nd4 499 2 factor factor NN cord-009571-mygj2nd4 499 3 was be VBD cord-009571-mygj2nd4 499 4 negative negative JJ cord-009571-mygj2nd4 499 5 in in IN cord-009571-mygj2nd4 499 6 4 4 CD cord-009571-mygj2nd4 499 7 and and CC cord-009571-mygj2nd4 499 8 latex latex NN cord-009571-mygj2nd4 499 9 positive positive JJ cord-009571-mygj2nd4 499 10 ] ] -RRB- cord-009571-mygj2nd4 499 11 : : : cord-009571-mygj2nd4 500 1 I60 I60 NNP cord-009571-mygj2nd4 500 2 in in IN cord-009571-mygj2nd4 500 3 one one CD cord-009571-mygj2nd4 500 4 case case NN cord-009571-mygj2nd4 500 5 . . . cord-009571-mygj2nd4 501 1 Blood blood NN cord-009571-mygj2nd4 501 2 urea urea NN cord-009571-mygj2nd4 501 3 nitrogen nitrogen NN cord-009571-mygj2nd4 501 4 and and CC cord-009571-mygj2nd4 501 5 serum serum NN cord-009571-mygj2nd4 501 6 creatinine creatinine NN cord-009571-mygj2nd4 501 7 were be VBD cord-009571-mygj2nd4 501 8 normal normal JJ cord-009571-mygj2nd4 501 9 in in IN cord-009571-mygj2nd4 501 10 each each DT cord-009571-mygj2nd4 501 11 patient patient NN cord-009571-mygj2nd4 501 12 ; ; : cord-009571-mygj2nd4 501 13 however however RB cord-009571-mygj2nd4 501 14 , , , cord-009571-mygj2nd4 501 15 the the DT cord-009571-mygj2nd4 501 16 24 24 CD cord-009571-mygj2nd4 501 17 hour hour NN cord-009571-mygj2nd4 501 18 urine urine NN cord-009571-mygj2nd4 501 19 protein protein NN cord-009571-mygj2nd4 501 20 excretion excretion NN cord-009571-mygj2nd4 501 21 ranged range VBD cord-009571-mygj2nd4 501 22 from from IN cord-009571-mygj2nd4 501 23 1.7 1.7 CD cord-009571-mygj2nd4 501 24 to to IN cord-009571-mygj2nd4 501 25 4.4 4.4 CD cord-009571-mygj2nd4 501 26 gm gm NNP cord-009571-mygj2nd4 501 27 . . . cord-009571-mygj2nd4 502 1 Three three CD cord-009571-mygj2nd4 502 2 patients patient NNS cord-009571-mygj2nd4 502 3 had have VBD cord-009571-mygj2nd4 502 4 an an DT cord-009571-mygj2nd4 502 5 abnormal abnormal JJ cord-009571-mygj2nd4 502 6 urine urine NN cord-009571-mygj2nd4 502 7 sediment sediment NN cord-009571-mygj2nd4 502 8 and and CC cord-009571-mygj2nd4 502 9 one one CD cord-009571-mygj2nd4 502 10 had have VBD cord-009571-mygj2nd4 502 11 myoglobinuria myoglobinuria NNS cord-009571-mygj2nd4 502 12 . . . cord-009571-mygj2nd4 503 1 Renal renal JJ cord-009571-mygj2nd4 503 2 biopsies biopsy NNS cord-009571-mygj2nd4 503 3 ( ( -LRB- cord-009571-mygj2nd4 503 4 4 4 CD cord-009571-mygj2nd4 503 5 patients patient NNS cord-009571-mygj2nd4 503 6 ) ) -RRB- cord-009571-mygj2nd4 503 7 showed show VBD cord-009571-mygj2nd4 503 8 a a DT cord-009571-mygj2nd4 503 9 mild mild JJ cord-009571-mygj2nd4 503 10 focal focal JJ cord-009571-mygj2nd4 503 11 segmental segmental JJ cord-009571-mygj2nd4 503 12 mesangial mesangial JJ cord-009571-mygj2nd4 503 13 increase increase NN cord-009571-mygj2nd4 503 14 . . . cord-009571-mygj2nd4 504 1 Immunofluorescence Immunofluorescence NNP cord-009571-mygj2nd4 504 2 was be VBD cord-009571-mygj2nd4 504 3 negative negative JJ cord-009571-mygj2nd4 504 4 in in IN cord-009571-mygj2nd4 504 5 one one CD cord-009571-mygj2nd4 504 6 biopsy biopsy NN cord-009571-mygj2nd4 504 7 and and CC cord-009571-mygj2nd4 504 8 mildly mildly RB cord-009571-mygj2nd4 504 9 positive positive JJ cord-009571-mygj2nd4 504 10 in in IN cord-009571-mygj2nd4 504 11 a a DT cord-009571-mygj2nd4 504 12 granular granular JJ cord-009571-mygj2nd4 504 13 pattern pattern NN cord-009571-mygj2nd4 504 14 for for IN cord-009571-mygj2nd4 504 15 IgG IgG NNP cord-009571-mygj2nd4 504 16 and and CC cord-009571-mygj2nd4 504 17 IgM IgM NNP cord-009571-mygj2nd4 504 18 in in IN cord-009571-mygj2nd4 504 19 2 2 CD cord-009571-mygj2nd4 504 20 others other NNS cord-009571-mygj2nd4 504 21 . . . cord-009571-mygj2nd4 505 1 Treatment treatment NN cord-009571-mygj2nd4 505 2 of of IN cord-009571-mygj2nd4 505 3 all all DT cord-009571-mygj2nd4 505 4 patients patient NNS cord-009571-mygj2nd4 505 5 with with IN cord-009571-mygj2nd4 505 6 high high JJ cord-009571-mygj2nd4 505 7 - - HYPH cord-009571-mygj2nd4 505 8 dose dose NN cord-009571-mygj2nd4 505 9 corticosteroids corticosteroid NNS cord-009571-mygj2nd4 505 10 led lead VBD cord-009571-mygj2nd4 505 11 to to IN cord-009571-mygj2nd4 505 12 rapid rapid JJ cord-009571-mygj2nd4 505 13 clearing clearing NN cord-009571-mygj2nd4 505 14 of of IN cord-009571-mygj2nd4 505 15 the the DT cord-009571-mygj2nd4 505 16 proteinuria proteinuria NN cord-009571-mygj2nd4 505 17 and and CC cord-009571-mygj2nd4 505 18 slower slow JJR cord-009571-mygj2nd4 505 19 improvement improvement NN cord-009571-mygj2nd4 505 20 of of IN cord-009571-mygj2nd4 505 21 the the DT cord-009571-mygj2nd4 505 22 polymyositis polymyositis NN cord-009571-mygj2nd4 505 23 . . . cord-009571-mygj2nd4 506 1 A a DT cord-009571-mygj2nd4 506 2 10-year 10-year CD cord-009571-mygj2nd4 506 3 review review NN cord-009571-mygj2nd4 506 4 in in IN cord-009571-mygj2nd4 506 5 our -PRON- PRP$ cord-009571-mygj2nd4 506 6 center center NN cord-009571-mygj2nd4 506 7 of of IN cord-009571-mygj2nd4 506 8 70 70 CD cord-009571-mygj2nd4 506 9 polymyositis polymyositis NN cord-009571-mygj2nd4 506 10 cases case NNS cord-009571-mygj2nd4 506 11 showed show VBD cord-009571-mygj2nd4 506 12 proteinuria proteinuria NN cord-009571-mygj2nd4 506 13 exceeding exceed VBG cord-009571-mygj2nd4 506 14 300 300 CD cord-009571-mygj2nd4 506 15 mg/24 mg/24 CD cord-009571-mygj2nd4 506 16 hours hour NNS cord-009571-mygj2nd4 506 17 in in IN cord-009571-mygj2nd4 506 18 9 9 CD cord-009571-mygj2nd4 506 19 patients patient NNS cord-009571-mygj2nd4 506 20 and and CC cord-009571-mygj2nd4 506 21 abnormal abnormal JJ cord-009571-mygj2nd4 506 22 urinary urinary JJ cord-009571-mygj2nd4 506 23 sediment sediment NN cord-009571-mygj2nd4 506 24 in in IN cord-009571-mygj2nd4 506 25 4 4 CD cord-009571-mygj2nd4 506 26 . . . cord-009571-mygj2nd4 507 1 None none NN cord-009571-mygj2nd4 507 2 of of IN cord-009571-mygj2nd4 507 3 these these DT cord-009571-mygj2nd4 507 4 latter latter JJ cord-009571-mygj2nd4 507 5 patients patient NNS cord-009571-mygj2nd4 507 6 had have VBD cord-009571-mygj2nd4 507 7 underlying underlying JJ cord-009571-mygj2nd4 507 8 malignancy malignancy NN cord-009571-mygj2nd4 507 9 . . . cord-009571-mygj2nd4 508 1 A a DT cord-009571-mygj2nd4 508 2 focal focal JJ cord-009571-mygj2nd4 508 3 glomerulonephritis glomerulonephritis NN cord-009571-mygj2nd4 508 4 associated associate VBN cord-009571-mygj2nd4 508 5 with with IN cord-009571-mygj2nd4 508 6 polymyositis polymyositis NNP cord-009571-mygj2nd4 508 7 may may MD cord-009571-mygj2nd4 508 8 be be VB cord-009571-mygj2nd4 508 9 more more RBR cord-009571-mygj2nd4 508 10 common common JJ cord-009571-mygj2nd4 508 11 than than IN cord-009571-mygj2nd4 508 12 is be VBZ cord-009571-mygj2nd4 508 13 generally generally RB cord-009571-mygj2nd4 508 14 appreciated appreciate VBN cord-009571-mygj2nd4 508 15 . . . cord-009571-mygj2nd4 509 1 Although although IN cord-009571-mygj2nd4 509 2 the the DT cord-009571-mygj2nd4 509 3 pathogenesis pathogenesis NN cord-009571-mygj2nd4 509 4 of of IN cord-009571-mygj2nd4 509 5 the the DT cord-009571-mygj2nd4 509 6 renal renal JJ cord-009571-mygj2nd4 509 7 lesion lesion NN cord-009571-mygj2nd4 509 8 in in IN cord-009571-mygj2nd4 509 9 these these DT cord-009571-mygj2nd4 509 10 cases case NNS cord-009571-mygj2nd4 509 11 is be VBZ cord-009571-mygj2nd4 509 12 unknown unknown JJ cord-009571-mygj2nd4 509 13 , , , cord-009571-mygj2nd4 509 14 it -PRON- PRP cord-009571-mygj2nd4 509 15 may may MD cord-009571-mygj2nd4 509 16 be be VB cord-009571-mygj2nd4 509 17 related relate VBN cord-009571-mygj2nd4 509 18 to to IN cord-009571-mygj2nd4 509 19 myoglobin myoglobin NN cord-009571-mygj2nd4 509 20 . . . cord-009571-mygj2nd4 510 1 Two two CD cord-009571-mygj2nd4 510 2 enzymes enzyme NNS cord-009571-mygj2nd4 510 3 of of IN cord-009571-mygj2nd4 510 4 the the DT cord-009571-mygj2nd4 510 5 purine purine NN cord-009571-mygj2nd4 510 6 nucleotide nucleotide JJ cord-009571-mygj2nd4 510 7 degradation degradation NN cord-009571-mygj2nd4 510 8 pathway pathway NN cord-009571-mygj2nd4 510 9 , , , cord-009571-mygj2nd4 510 10 adenosine adenosine NN cord-009571-mygj2nd4 510 11 deaminase deaminase NNP cord-009571-mygj2nd4 510 12 and and CC cord-009571-mygj2nd4 510 13 purine purine NN cord-009571-mygj2nd4 510 14 nucleoside nucleoside NN cord-009571-mygj2nd4 510 15 phosphorylase phosphorylase NN cord-009571-mygj2nd4 510 16 , , , cord-009571-mygj2nd4 510 17 are be VBP cord-009571-mygj2nd4 510 18 associated associate VBN cord-009571-mygj2nd4 510 19 with with IN cord-009571-mygj2nd4 510 20 specific specific JJ cord-009571-mygj2nd4 510 21 immunodeficiency immunodeficiency NN cord-009571-mygj2nd4 510 22 syndromes syndrome NNS cord-009571-mygj2nd4 510 23 . . . cord-009571-mygj2nd4 511 1 A a DT cord-009571-mygj2nd4 511 2 third third JJ cord-009571-mygj2nd4 511 3 catabolic catabolic JJ cord-009571-mygj2nd4 511 4 enzyme enzyme NN cord-009571-mygj2nd4 511 5 , , , cord-009571-mygj2nd4 511 6 5'-nucleotidase 5'-nucleotidase NNP cord-009571-mygj2nd4 511 7 , , , cord-009571-mygj2nd4 511 8 was be VBD cord-009571-mygj2nd4 511 9 measured measure VBN cord-009571-mygj2nd4 511 10 on on IN cord-009571-mygj2nd4 511 11 the the DT cord-009571-mygj2nd4 511 12 external external JJ cord-009571-mygj2nd4 511 13 surface surface NN cord-009571-mygj2nd4 511 14 of of IN cord-009571-mygj2nd4 511 15 peripheral peripheral JJ cord-009571-mygj2nd4 511 16 circulating circulating JJ cord-009571-mygj2nd4 511 17 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 511 18 from from IN cord-009571-mygj2nd4 511 19 patients patient NNS cord-009571-mygj2nd4 511 20 with with IN cord-009571-mygj2nd4 511 21 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 511 22 deficiencies deficiency NNS cord-009571-mygj2nd4 511 23 . . . cord-009571-mygj2nd4 512 1 All all DT cord-009571-mygj2nd4 512 2 8 8 CD cord-009571-mygj2nd4 512 3 male male JJ cord-009571-mygj2nd4 512 4 patients patient NNS cord-009571-mygj2nd4 512 5 with with IN cord-009571-mygj2nd4 512 6 congenital congenital JJ cord-009571-mygj2nd4 512 7 agammaglobulinemia agammaglobulinemia NN cord-009571-mygj2nd4 512 8 demonstrate demonstrate VBP cord-009571-mygj2nd4 512 9 reduced reduce VBN cord-009571-mygj2nd4 512 10 activity activity NN cord-009571-mygj2nd4 512 11 of of IN cord-009571-mygj2nd4 512 12 lymphocyte lymphocyte NN cord-009571-mygj2nd4 512 13 ecto-5'-nucleotidase ecto-5'-nucleotidase NN cord-009571-mygj2nd4 512 14 to to IN cord-009571-mygj2nd4 512 15 30 30 CD cord-009571-mygj2nd4 512 16 to to TO cord-009571-mygj2nd4 512 17 48 48 CD cord-009571-mygj2nd4 512 18 % % NN cord-009571-mygj2nd4 512 19 of of IN cord-009571-mygj2nd4 512 20 the the DT cord-009571-mygj2nd4 512 21 normal normal JJ cord-009571-mygj2nd4 512 22 value value NN cord-009571-mygj2nd4 512 23 . . . cord-009571-mygj2nd4 513 1 The the DT cord-009571-mygj2nd4 513 2 mean mean JJ cord-009571-mygj2nd4 513 3 activity activity NN cord-009571-mygj2nd4 513 4 is be VBZ cord-009571-mygj2nd4 513 5 5.7 5.7 CD cord-009571-mygj2nd4 513 6 f f CD cord-009571-mygj2nd4 513 7 1 1 CD cord-009571-mygj2nd4 514 1 .O .O NFP cord-009571-mygj2nd4 514 2 nM nM NNP cord-009571-mygj2nd4 514 3 / / SYM cord-009571-mygj2nd4 514 4 hr hr NN cord-009571-mygj2nd4 514 5 / / SYM cord-009571-mygj2nd4 514 6 lOB lob NN cord-009571-mygj2nd4 514 7 cells cell NNS cord-009571-mygj2nd4 514 8 for for IN cord-009571-mygj2nd4 514 9 congenital congenital JJ cord-009571-mygj2nd4 514 10 agammaglobulinemia agammaglobulinemia NN cord-009571-mygj2nd4 514 11 as as IN cord-009571-mygj2nd4 514 12 compared compare VBN cord-009571-mygj2nd4 514 13 to to IN cord-009571-mygj2nd4 514 14 the the DT cord-009571-mygj2nd4 514 15 mean mean JJ cord-009571-mygj2nd4 514 16 normal normal JJ cord-009571-mygj2nd4 514 17 value value NN cord-009571-mygj2nd4 514 18 of of IN cord-009571-mygj2nd4 514 19 15.0 15.0 CD cord-009571-mygj2nd4 514 20 * * NFP cord-009571-mygj2nd4 514 21 5.6 5.6 CD cord-009571-mygj2nd4 514 22 . . . cord-009571-mygj2nd4 515 1 Patients patient NNS cord-009571-mygj2nd4 515 2 with with IN cord-009571-mygj2nd4 515 3 common common JJ cord-009571-mygj2nd4 515 4 , , , cord-009571-mygj2nd4 515 5 variable variable JJ cord-009571-mygj2nd4 515 6 hypogammaglobulinemia hypogammaglobulinemia NN cord-009571-mygj2nd4 515 7 or or CC cord-009571-mygj2nd4 515 8 selective selective JJ cord-009571-mygj2nd4 515 9 IgA IgA NNP cord-009571-mygj2nd4 515 10 deficiency deficiency NN cord-009571-mygj2nd4 515 11 have have VBP cord-009571-mygj2nd4 515 12 values value NNS cord-009571-mygj2nd4 515 13 within within IN cord-009571-mygj2nd4 515 14 the the DT cord-009571-mygj2nd4 515 15 normal normal JJ cord-009571-mygj2nd4 515 16 range range NN cord-009571-mygj2nd4 515 17 . . . cord-009571-mygj2nd4 516 1 Two two CD cord-009571-mygj2nd4 516 2 other other JJ cord-009571-mygj2nd4 516 3 lymphocyte lymphocyte NN cord-009571-mygj2nd4 516 4 plasma plasma NN cord-009571-mygj2nd4 516 5 membrane membrane NN cord-009571-mygj2nd4 516 6 ectoenzymes ectoenzyme NNS cord-009571-mygj2nd4 516 7 , , , cord-009571-mygj2nd4 516 8 ATP'ase ATP'ase NNP cord-009571-mygj2nd4 516 9 and and CC cord-009571-mygj2nd4 516 10 nonspecific nonspecific JJ cord-009571-mygj2nd4 516 11 phosphatase phosphatase NN cord-009571-mygj2nd4 516 12 , , , cord-009571-mygj2nd4 516 13 have have VBP cord-009571-mygj2nd4 516 14 similar similar JJ cord-009571-mygj2nd4 516 15 values value NNS cord-009571-mygj2nd4 516 16 in in IN cord-009571-mygj2nd4 516 17 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 516 18 from from IN cord-009571-mygj2nd4 516 19 normal normal JJ cord-009571-mygj2nd4 516 20 subjects subject NNS cord-009571-mygj2nd4 516 21 or or CC cord-009571-mygj2nd4 516 22 from from IN cord-009571-mygj2nd4 516 23 subjects subject NNS cord-009571-mygj2nd4 516 24 with with IN cord-009571-mygj2nd4 516 25 congenital congenital JJ cord-009571-mygj2nd4 516 26 agammaglobulinemia agammaglobulinemia NN cord-009571-mygj2nd4 516 27 . . . cord-009571-mygj2nd4 517 1 The the DT cord-009571-mygj2nd4 517 2 activity activity NN cord-009571-mygj2nd4 517 3 of of IN cord-009571-mygj2nd4 517 4 5'-nucleotidase 5'-nucleotidase CD cord-009571-mygj2nd4 517 5 in in IN cord-009571-mygj2nd4 517 6 lymphocyte lymphocyte NN cord-009571-mygj2nd4 517 7 lysates lysate NNS cord-009571-mygj2nd4 517 8 has have VBZ cord-009571-mygj2nd4 517 9 similar similar JJ cord-009571-mygj2nd4 517 10 values value NNS cord-009571-mygj2nd4 517 11 in in IN cord-009571-mygj2nd4 517 12 normal normal JJ cord-009571-mygj2nd4 517 13 and and CC cord-009571-mygj2nd4 517 14 enzyme enzyme JJ cord-009571-mygj2nd4 517 15 deficient deficient JJ cord-009571-mygj2nd4 517 16 subjects subject NNS cord-009571-mygj2nd4 517 17 . . . cord-009571-mygj2nd4 518 1 Ecto-5'-nucleotidase Ecto-5'-nucleotidase NNP cord-009571-mygj2nd4 518 2 has have VBZ cord-009571-mygj2nd4 518 3 similar similar JJ cord-009571-mygj2nd4 518 4 activity activity NN cord-009571-mygj2nd4 518 5 in in IN cord-009571-mygj2nd4 518 6 both both CC cord-009571-mygj2nd4 518 7 T T NNP cord-009571-mygj2nd4 518 8 and and CC cord-009571-mygj2nd4 518 9 non non JJ cord-009571-mygj2nd4 518 10 - - JJ cord-009571-mygj2nd4 518 11 T t JJ cord-009571-mygj2nd4 518 12 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 518 13 in in IN cord-009571-mygj2nd4 518 14 all all DT cord-009571-mygj2nd4 518 15 subjects subject NNS cord-009571-mygj2nd4 518 16 and and CC cord-009571-mygj2nd4 518 17 the the DT cord-009571-mygj2nd4 518 18 deficiency deficiency NN cord-009571-mygj2nd4 518 19 occurs occur VBZ cord-009571-mygj2nd4 518 20 in in IN cord-009571-mygj2nd4 518 21 both both PDT cord-009571-mygj2nd4 518 22 these these DT cord-009571-mygj2nd4 518 23 categories category NNS cord-009571-mygj2nd4 518 24 of of IN cord-009571-mygj2nd4 518 25 cells cell NNS cord-009571-mygj2nd4 518 26 in in IN cord-009571-mygj2nd4 518 27 the the DT cord-009571-mygj2nd4 518 28 affected affected JJ cord-009571-mygj2nd4 518 29 patients patient NNS cord-009571-mygj2nd4 518 30 . . . cord-009571-mygj2nd4 519 1 Ecto-5'-nucleotidase Ecto-5'-nucleotidase NNP cord-009571-mygj2nd4 519 2 from from IN cord-009571-mygj2nd4 519 3 normal normal JJ cord-009571-mygj2nd4 519 4 and and CC cord-009571-mygj2nd4 519 5 enzyme enzyme NN cord-009571-mygj2nd4 519 6 deficient deficient JJ cord-009571-mygj2nd4 519 7 subjects subject NNS cord-009571-mygj2nd4 519 8 has have VBZ cord-009571-mygj2nd4 519 9 a a DT cord-009571-mygj2nd4 519 10 similar similar JJ cord-009571-mygj2nd4 519 11 p p NN cord-009571-mygj2nd4 519 12 H h NN cord-009571-mygj2nd4 519 13 optimum'of optimum'of NN cord-009571-mygj2nd4 519 14 7.5 7.5 CD cord-009571-mygj2nd4 519 15 , , , cord-009571-mygj2nd4 519 16 is be VBZ cord-009571-mygj2nd4 519 17 similarly similarly RB cord-009571-mygj2nd4 519 18 inhibited inhibit VBN cord-009571-mygj2nd4 519 19 by by IN cord-009571-mygj2nd4 519 20 adenosine-5'4 adenosine-5'4 NNP cord-009571-mygj2nd4 519 21 , , , cord-009571-mygj2nd4 519 22 P p NN cord-009571-mygj2nd4 519 23 - - HYPH cord-009571-mygj2nd4 519 24 methylene methylene NN cord-009571-mygj2nd4 519 25 diphosphonate diphosphonate NN cord-009571-mygj2nd4 519 26 , , , cord-009571-mygj2nd4 519 27 has have VBZ cord-009571-mygj2nd4 519 28 hyperbolic hyperbolic JJ cord-009571-mygj2nd4 519 29 kinetics kinetic NNS cord-009571-mygj2nd4 519 30 and and CC cord-009571-mygj2nd4 519 31 a a DT cord-009571-mygj2nd4 519 32 similar similar JJ cord-009571-mygj2nd4 519 33 Michaelis Michaelis NNP cord-009571-mygj2nd4 519 34 constant constant NN cord-009571-mygj2nd4 519 35 of of IN cord-009571-mygj2nd4 519 36 25 25 CD cord-009571-mygj2nd4 519 37 pM pm NN cord-009571-mygj2nd4 519 38 for for IN cord-009571-mygj2nd4 519 39 AMP amp NN cord-009571-mygj2nd4 519 40 . . . cord-009571-mygj2nd4 520 1 These these DT cord-009571-mygj2nd4 520 2 data datum NNS cord-009571-mygj2nd4 520 3 suggest suggest VBP cord-009571-mygj2nd4 520 4 that that IN cord-009571-mygj2nd4 520 5 the the DT cord-009571-mygj2nd4 520 6 reduction reduction NN cord-009571-mygj2nd4 520 7 of of IN cord-009571-mygj2nd4 520 8 lymphocyte lymphocyte NN cord-009571-mygj2nd4 520 9 5'-nucleotidase 5'-nucleotidase CD cord-009571-mygj2nd4 520 10 activity activity NN cord-009571-mygj2nd4 520 11 is be VBZ cord-009571-mygj2nd4 520 12 an an DT cord-009571-mygj2nd4 520 13 abnormality abnormality NN cord-009571-mygj2nd4 520 14 localized localize VBN cord-009571-mygj2nd4 520 15 to to IN cord-009571-mygj2nd4 520 16 the the DT cord-009571-mygj2nd4 520 17 plasma plasma NN cord-009571-mygj2nd4 520 18 membrane membrane NN cord-009571-mygj2nd4 520 19 in in IN cord-009571-mygj2nd4 520 20 this this DT cord-009571-mygj2nd4 520 21 X x NN cord-009571-mygj2nd4 520 22 - - HYPH cord-009571-mygj2nd4 520 23 linked link VBN cord-009571-mygj2nd4 520 24 , , , cord-009571-mygj2nd4 520 25 B b NN cord-009571-mygj2nd4 520 26 - - HYPH cord-009571-mygj2nd4 520 27 cell cell NN cord-009571-mygj2nd4 520 28 immunodeficiency immunodeficiency NN cord-009571-mygj2nd4 520 29 syndrome syndrome NN cord-009571-mygj2nd4 520 30 . . . cord-009571-mygj2nd4 521 1 In in IN cord-009571-mygj2nd4 521 2 vivo vivo NN cord-009571-mygj2nd4 521 3 clearance clearance NN cord-009571-mygj2nd4 521 4 of of IN cord-009571-mygj2nd4 521 5 exogenous exogenous JJ cord-009571-mygj2nd4 521 6 single single RB cord-009571-mygj2nd4 521 7 - - HYPH cord-009571-mygj2nd4 521 8 stranded strand VBN cord-009571-mygj2nd4 521 9 DNA dna NN cord-009571-mygj2nd4 521 10 ( ( -LRB- cord-009571-mygj2nd4 521 11 ssDNA ssdna NN cord-009571-mygj2nd4 521 12 ) ) -RRB- cord-009571-mygj2nd4 521 13 is be VBZ cord-009571-mygj2nd4 521 14 extremely extremely RB cord-009571-mygj2nd4 521 15 rapid rapid JJ cord-009571-mygj2nd4 521 16 and and CC cord-009571-mygj2nd4 521 17 occurs occur VBZ cord-009571-mygj2nd4 521 18 primarily primarily RB cord-009571-mygj2nd4 521 19 through through IN cord-009571-mygj2nd4 521 20 the the DT cord-009571-mygj2nd4 521 21 liver liver NN cord-009571-mygj2nd4 521 22 . . . cord-009571-mygj2nd4 522 1 With with IN cord-009571-mygj2nd4 522 2 higher high JJR cord-009571-mygj2nd4 522 3 doses dose NNS cord-009571-mygj2nd4 522 4 of of IN cord-009571-mygj2nd4 522 5 ssDNA ssdna NN cord-009571-mygj2nd4 522 6 , , , cord-009571-mygj2nd4 522 7 however however RB cord-009571-mygj2nd4 522 8 , , , cord-009571-mygj2nd4 522 9 both both DT cord-009571-mygj2nd4 522 10 liver liver NN cord-009571-mygj2nd4 522 11 uptake uptake NN cord-009571-mygj2nd4 522 12 and and CC cord-009571-mygj2nd4 522 13 blood blood NN cord-009571-mygj2nd4 522 14 clearance clearance NN cord-009571-mygj2nd4 522 15 approach approach VBP cord-009571-mygj2nd4 522 16 a a DT cord-009571-mygj2nd4 522 17 maximum maximum NN cord-009571-mygj2nd4 522 18 , , , cord-009571-mygj2nd4 522 19 enabling enable VBG cord-009571-mygj2nd4 522 20 large large JJ cord-009571-mygj2nd4 522 21 molecular molecular JJ cord-009571-mygj2nd4 522 22 weight weight NN cord-009571-mygj2nd4 522 23 ssDNA ssdna NN cord-009571-mygj2nd4 522 24 to to TO cord-009571-mygj2nd4 522 25 persist persist VB cord-009571-mygj2nd4 522 26 in in IN cord-009571-mygj2nd4 522 27 the the DT cord-009571-mygj2nd4 522 28 circulation circulation NN cord-009571-mygj2nd4 522 29 ( ( -LRB- cord-009571-mygj2nd4 522 30 Emlen Emlen NNP cord-009571-mygj2nd4 522 31 , , , cord-009571-mygj2nd4 522 32 Mannik Mannik NNP cord-009571-mygj2nd4 522 33 ; ; : cord-009571-mygj2nd4 522 34 J J NNP cord-009571-mygj2nd4 522 35 Exp Exp NNP cord-009571-mygj2nd4 522 36 Med Med NNP cord-009571-mygj2nd4 522 37 , , , cord-009571-mygj2nd4 522 38 March March NNP cord-009571-mygj2nd4 522 39 , , , cord-009571-mygj2nd4 522 40 1978 1978 CD cord-009571-mygj2nd4 522 41 ) ) -RRB- cord-009571-mygj2nd4 522 42 . . . cord-009571-mygj2nd4 523 1 In in IN cord-009571-mygj2nd4 523 2 the the DT cord-009571-mygj2nd4 523 3 present present JJ cord-009571-mygj2nd4 523 4 study study NN cord-009571-mygj2nd4 523 5 , , , cord-009571-mygj2nd4 523 6 we -PRON- PRP cord-009571-mygj2nd4 523 7 examined examine VBD cord-009571-mygj2nd4 523 8 the the DT cord-009571-mygj2nd4 523 9 effects effect NNS cord-009571-mygj2nd4 523 10 of of IN cord-009571-mygj2nd4 523 11 prior prior JJ cord-009571-mygj2nd4 523 12 saturation saturation NN cord-009571-mygj2nd4 523 13 of of IN cord-009571-mygj2nd4 523 14 the the DT cord-009571-mygj2nd4 523 15 liver liver NN cord-009571-mygj2nd4 523 16 with with IN cord-009571-mygj2nd4 523 17 immune immune JJ cord-009571-mygj2nd4 523 18 complexes complex NNS cord-009571-mygj2nd4 523 19 on on IN cord-009571-mygj2nd4 523 20 the the DT cord-009571-mygj2nd4 523 21 clearance clearance NN cord-009571-mygj2nd4 523 22 kinetics kinetic NNS cord-009571-mygj2nd4 523 23 of of IN cord-009571-mygj2nd4 523 24 ssDNA ssdna NN cord-009571-mygj2nd4 523 25 . . . cord-009571-mygj2nd4 524 1 Heat heat NN cord-009571-mygj2nd4 524 2 denatured denatured JJ cord-009571-mygj2nd4 524 3 calf calf NN cord-009571-mygj2nd4 524 4 thymus thymus NN cord-009571-mygj2nd4 524 5 ' ' '' cord-009571-mygj2nd4 525 1 * * NFP cord-009571-mygj2nd4 525 2 ' ' '' cord-009571-mygj2nd4 525 3 I -PRON- PRP cord-009571-mygj2nd4 525 4 ssDNA ssdna RB cord-009571-mygj2nd4 525 5 was be VBD cord-009571-mygj2nd4 525 6 chromatographed chromatographe VBN cord-009571-mygj2nd4 525 7 on on IN cord-009571-mygj2nd4 525 8 hydroxyapatite hydroxyapatite NN cord-009571-mygj2nd4 525 9 and and CC cord-009571-mygj2nd4 525 10 a a DT cord-009571-mygj2nd4 525 11 defined define VBN cord-009571-mygj2nd4 525 12 molecular molecular JJ cord-009571-mygj2nd4 525 13 weight weight NN cord-009571-mygj2nd4 525 14 was be VBD cord-009571-mygj2nd4 525 15 obtained obtain VBN cord-009571-mygj2nd4 525 16 by by IN cord-009571-mygj2nd4 525 17 gel gel NN cord-009571-mygj2nd4 525 18 filtration filtration NN cord-009571-mygj2nd4 525 19 over over IN cord-009571-mygj2nd4 525 20 Sepharose Sepharose NNP cord-009571-mygj2nd4 525 21 4B. 4b. CD cord-009571-mygj2nd4 525 22 Immune Immune NNP cord-009571-mygj2nd4 525 23 complexes complex NNS cord-009571-mygj2nd4 525 24 were be VBD cord-009571-mygj2nd4 525 25 prepared prepare VBN cord-009571-mygj2nd4 525 26 at at IN cord-009571-mygj2nd4 525 27 5-fold 5-fold CD cord-009571-mygj2nd4 525 28 antigen antigen NN cord-009571-mygj2nd4 525 29 excess excess NN cord-009571-mygj2nd4 525 30 with with IN cord-009571-mygj2nd4 525 31 human human JJ cord-009571-mygj2nd4 525 32 serum serum NN cord-009571-mygj2nd4 525 33 albumin albumin NN cord-009571-mygj2nd4 525 34 and and CC cord-009571-mygj2nd4 525 35 purified purify VBN cord-009571-mygj2nd4 525 36 rabbit rabbit NN cord-009571-mygj2nd4 525 37 anti anti JJ cord-009571-mygj2nd4 525 38 - - JJ cord-009571-mygj2nd4 525 39 human human JJ cord-009571-mygj2nd4 525 40 serum serum NN cord-009571-mygj2nd4 525 41 albumin albumin NN cord-009571-mygj2nd4 525 42 . . . cord-009571-mygj2nd4 526 1 Female female JJ cord-009571-mygj2nd4 526 2 C57BL/6J C57BL/6J NNP cord-009571-mygj2nd4 526 3 mice mouse NNS cord-009571-mygj2nd4 526 4 were be VBD cord-009571-mygj2nd4 526 5 injected inject VBN cord-009571-mygj2nd4 526 6 at at IN cord-009571-mygj2nd4 526 7 time time NN cord-009571-mygj2nd4 526 8 0 0 NFP cord-009571-mygj2nd4 526 9 with with IN cord-009571-mygj2nd4 526 10 immune immune JJ cord-009571-mygj2nd4 526 11 complexes complex NNS cord-009571-mygj2nd4 526 12 containing contain VBG cord-009571-mygj2nd4 526 13 5 5 CD cord-009571-mygj2nd4 526 14 mg mg NNP cord-009571-mygj2nd4 526 15 antibodies antibody NNS cord-009571-mygj2nd4 526 16 or or CC cord-009571-mygj2nd4 526 17 with with IN cord-009571-mygj2nd4 526 18 buffer buffer NN cord-009571-mygj2nd4 526 19 . . . cord-009571-mygj2nd4 527 1 At at IN cord-009571-mygj2nd4 527 2 3 3 CD cord-009571-mygj2nd4 527 3 , , , cord-009571-mygj2nd4 527 4 6 6 CD cord-009571-mygj2nd4 527 5 , , , cord-009571-mygj2nd4 527 6 12 12 CD cord-009571-mygj2nd4 527 7 , , , cord-009571-mygj2nd4 527 8 24 24 CD cord-009571-mygj2nd4 527 9 , , , cord-009571-mygj2nd4 527 10 or or CC cord-009571-mygj2nd4 527 11 48 48 CD cord-009571-mygj2nd4 527 12 hours hour NNS cord-009571-mygj2nd4 527 13 , , , cord-009571-mygj2nd4 527 14 animals animal NNS cord-009571-mygj2nd4 527 15 were be VBD cord-009571-mygj2nd4 527 16 given give VBN cord-009571-mygj2nd4 527 17 50 50 CD cord-009571-mygj2nd4 527 18 pg pg NN cord-009571-mygj2nd4 527 19 of of IN cord-009571-mygj2nd4 527 20 ' ' CD cord-009571-mygj2nd4 527 21 9 9 CD cord-009571-mygj2nd4 527 22 ssDNA ssdna NN cord-009571-mygj2nd4 527 23 ; ; , cord-009571-mygj2nd4 527 24 serial serial JJ cord-009571-mygj2nd4 527 25 blood blood NN cord-009571-mygj2nd4 527 26 samples sample NNS cord-009571-mygj2nd4 527 27 were be VBD cord-009571-mygj2nd4 527 28 assayed assay VBN cord-009571-mygj2nd4 527 29 for for IN cord-009571-mygj2nd4 527 30 radioactivity radioactivity NN cord-009571-mygj2nd4 527 31 and and CC cord-009571-mygj2nd4 527 32 clearance clearance NN cord-009571-mygj2nd4 527 33 velocities velocity NNS cord-009571-mygj2nd4 527 34 were be VBD cord-009571-mygj2nd4 527 35 calculated calculate VBN cord-009571-mygj2nd4 527 36 by by IN cord-009571-mygj2nd4 527 37 linear linear JJ cord-009571-mygj2nd4 527 38 regression regression NN cord-009571-mygj2nd4 527 39 analysis analysis NN cord-009571-mygj2nd4 527 40 . . . cord-009571-mygj2nd4 528 1 Clearance clearance NN cord-009571-mygj2nd4 528 2 of of IN cord-009571-mygj2nd4 528 3 ssDNA ssdna NN cord-009571-mygj2nd4 528 4 was be VBD cord-009571-mygj2nd4 528 5 slowed slow VBN cord-009571-mygj2nd4 528 6 in in IN cord-009571-mygj2nd4 528 7 the the DT cord-009571-mygj2nd4 528 8 mice mouse NNS cord-009571-mygj2nd4 528 9 pretreated pretreate VBN cord-009571-mygj2nd4 528 10 with with IN cord-009571-mygj2nd4 528 11 immune immune JJ cord-009571-mygj2nd4 528 12 complexes complex NNS cord-009571-mygj2nd4 528 13 . . . cord-009571-mygj2nd4 529 1 Control control NN cord-009571-mygj2nd4 529 2 mice mouse NNS cord-009571-mygj2nd4 529 3 cleared clear VBD cord-009571-mygj2nd4 529 4 ssDNA ssdna RB cord-009571-mygj2nd4 529 5 at at IN cord-009571-mygj2nd4 529 6 a a DT cord-009571-mygj2nd4 529 7 rate rate NN cord-009571-mygj2nd4 529 8 of of IN cord-009571-mygj2nd4 529 9 2.63 2.63 CD cord-009571-mygj2nd4 529 10 f f NN cord-009571-mygj2nd4 529 11 0.27 0.27 CD cord-009571-mygj2nd4 529 12 pg pg NNP cord-009571-mygj2nd4 529 13 / / SYM cord-009571-mygj2nd4 529 14 ml ml NNP cord-009571-mygj2nd4 529 15 / / SYM cord-009571-mygj2nd4 529 16 min min NNP cord-009571-mygj2nd4 529 17 , , , cord-009571-mygj2nd4 529 18 while while IN cord-009571-mygj2nd4 529 19 animals animal NNS cord-009571-mygj2nd4 529 20 pretreated pretreate VBN cord-009571-mygj2nd4 529 21 with with IN cord-009571-mygj2nd4 529 22 immune immune JJ cord-009571-mygj2nd4 529 23 complexes complex NNS cord-009571-mygj2nd4 529 24 cleared clear VBD cord-009571-mygj2nd4 529 25 the the DT cord-009571-mygj2nd4 529 26 ssDNA ssdna NN cord-009571-mygj2nd4 529 27 at at IN cord-009571-mygj2nd4 529 28 a a DT cord-009571-mygj2nd4 529 29 rate rate NN cord-009571-mygj2nd4 529 30 of of IN cord-009571-mygj2nd4 529 31 1.70 1.70 CD cord-009571-mygj2nd4 529 32 f f NN cord-009571-mygj2nd4 529 33 0.04 0.04 CD cord-009571-mygj2nd4 529 34 at at IN cord-009571-mygj2nd4 529 35 3 3 CD cord-009571-mygj2nd4 529 36 hours hour NNS cord-009571-mygj2nd4 529 37 ( ( -LRB- cord-009571-mygj2nd4 529 38 P p NN cord-009571-mygj2nd4 529 39 < < XX cord-009571-mygj2nd4 529 40 0.01 0.01 CD cord-009571-mygj2nd4 529 41 ) ) -RRB- cord-009571-mygj2nd4 529 42 , , , cord-009571-mygj2nd4 529 43 1.36 1.36 CD cord-009571-mygj2nd4 529 44 f f NN cord-009571-mygj2nd4 529 45 0.31 0.31 CD cord-009571-mygj2nd4 529 46 at at IN cord-009571-mygj2nd4 529 47 6 6 CD cord-009571-mygj2nd4 529 48 hours hour NNS cord-009571-mygj2nd4 530 1 ( ( -LRB- cord-009571-mygj2nd4 530 2 P p NN cord-009571-mygj2nd4 530 3 < < XX cord-009571-mygj2nd4 530 4 0.001 0.001 CD cord-009571-mygj2nd4 530 5 ) ) -RRB- cord-009571-mygj2nd4 530 6 and and CC cord-009571-mygj2nd4 530 7 1.39 1.39 CD cord-009571-mygj2nd4 530 8 f f NNP cord-009571-mygj2nd4 530 9 0.49 0.49 CD cord-009571-mygj2nd4 530 10 at at IN cord-009571-mygj2nd4 530 11 12 12 CD cord-009571-mygj2nd4 530 12 hours hour NNS cord-009571-mygj2nd4 530 13 ( ( -LRB- cord-009571-mygj2nd4 530 14 P p NN cord-009571-mygj2nd4 530 15 < < XX cord-009571-mygj2nd4 530 16 0.01 0.01 CD cord-009571-mygj2nd4 530 17 ) ) -RRB- cord-009571-mygj2nd4 530 18 . . . cord-009571-mygj2nd4 531 1 Clearance clearance NN cord-009571-mygj2nd4 531 2 returned return VBD cord-009571-mygj2nd4 531 3 to to IN cord-009571-mygj2nd4 531 4 normal normal JJ cord-009571-mygj2nd4 531 5 at at IN cord-009571-mygj2nd4 531 6 24 24 CD cord-009571-mygj2nd4 531 7 and and CC cord-009571-mygj2nd4 531 8 48 48 CD cord-009571-mygj2nd4 531 9 hours hour NNS cord-009571-mygj2nd4 531 10 . . . cord-009571-mygj2nd4 532 1 The the DT cord-009571-mygj2nd4 532 2 degree degree NN cord-009571-mygj2nd4 532 3 of of IN cord-009571-mygj2nd4 532 4 suppression suppression NN cord-009571-mygj2nd4 532 5 of of IN cord-009571-mygj2nd4 532 6 ssDNA ssdna JJ cord-009571-mygj2nd4 532 7 clearance clearance NN cord-009571-mygj2nd4 532 8 velocity velocity NN cord-009571-mygj2nd4 532 9 at at IN cord-009571-mygj2nd4 532 10 different different JJ cord-009571-mygj2nd4 532 11 times time NNS cord-009571-mygj2nd4 532 12 after after IN cord-009571-mygj2nd4 532 13 administration administration NN cord-009571-mygj2nd4 532 14 of of IN cord-009571-mygj2nd4 532 15 immune immune JJ cord-009571-mygj2nd4 532 16 complexes complex NNS cord-009571-mygj2nd4 532 17 correlated correlate VBN cord-009571-mygj2nd4 532 18 with with IN cord-009571-mygj2nd4 532 19 the the DT cord-009571-mygj2nd4 532 20 previously previously RB cord-009571-mygj2nd4 532 21 established establish VBN cord-009571-mygj2nd4 532 22 values value NNS cord-009571-mygj2nd4 532 23 for for IN cord-009571-mygj2nd4 532 24 the the DT cord-009571-mygj2nd4 532 25 amount amount NN cord-009571-mygj2nd4 532 26 of of IN cord-009571-mygj2nd4 532 27 immune immune JJ cord-009571-mygj2nd4 532 28 complexes complex NNS cord-009571-mygj2nd4 532 29 present present JJ cord-009571-mygj2nd4 532 30 in in IN cord-009571-mygj2nd4 532 31 the the DT cord-009571-mygj2nd4 532 32 liver liver NN cord-009571-mygj2nd4 532 33 at at IN cord-009571-mygj2nd4 532 34 a a DT cord-009571-mygj2nd4 532 35 given give VBN cord-009571-mygj2nd4 532 36 time time NN cord-009571-mygj2nd4 532 37 . . . cord-009571-mygj2nd4 533 1 To to TO cord-009571-mygj2nd4 533 2 examine examine VB cord-009571-mygj2nd4 533 3 the the DT cord-009571-mygj2nd4 533 4 effects effect NNS cord-009571-mygj2nd4 533 5 of of IN cord-009571-mygj2nd4 533 6 pretreatment pretreatment NN cord-009571-mygj2nd4 533 7 with with IN cord-009571-mygj2nd4 533 8 immune immune JJ cord-009571-mygj2nd4 533 9 complexes complex NNS cord-009571-mygj2nd4 533 10 on on IN cord-009571-mygj2nd4 533 11 the the DT cord-009571-mygj2nd4 533 12 saturability saturability NN cord-009571-mygj2nd4 533 13 of of IN cord-009571-mygj2nd4 533 14 ssDNA ssdna JJ cord-009571-mygj2nd4 533 15 clearance clearance NN cord-009571-mygj2nd4 533 16 mechanisms mechanism NNS cord-009571-mygj2nd4 533 17 , , , cord-009571-mygj2nd4 533 18 10 10 CD cord-009571-mygj2nd4 533 19 , , , cord-009571-mygj2nd4 533 20 50 50 CD cord-009571-mygj2nd4 533 21 , , , cord-009571-mygj2nd4 533 22 or or CC cord-009571-mygj2nd4 533 23 100 100 CD cord-009571-mygj2nd4 533 24 pg pg NN cord-009571-mygj2nd4 533 25 of of IN cord-009571-mygj2nd4 533 26 ssDNA ssDNA NNP cord-009571-mygj2nd4 533 27 were be VBD cord-009571-mygj2nd4 533 28 given give VBN cord-009571-mygj2nd4 533 29 6 6 CD cord-009571-mygj2nd4 533 30 hours hour NNS cord-009571-mygj2nd4 533 31 after after IN cord-009571-mygj2nd4 533 32 administration administration NN cord-009571-mygj2nd4 533 33 of of IN cord-009571-mygj2nd4 533 34 immune immune JJ cord-009571-mygj2nd4 533 35 complexes complex NNS cord-009571-mygj2nd4 533 36 . . . cord-009571-mygj2nd4 534 1 With with IN cord-009571-mygj2nd4 534 2 the the DT cord-009571-mygj2nd4 534 3 100 100 CD cord-009571-mygj2nd4 534 4 pg pg NN cord-009571-mygj2nd4 534 5 dose dose VBD cord-009571-mygj2nd4 534 6 the the DT cord-009571-mygj2nd4 534 7 clearance clearance NN cord-009571-mygj2nd4 534 8 velocity velocity NN cord-009571-mygj2nd4 534 9 approached approach VBD cord-009571-mygj2nd4 534 10 a a DT cord-009571-mygj2nd4 534 11 maximum maximum NN cord-009571-mygj2nd4 534 12 , , , cord-009571-mygj2nd4 534 13 but but CC cord-009571-mygj2nd4 534 14 this this DT cord-009571-mygj2nd4 534 15 value value NN cord-009571-mygj2nd4 534 16 was be VBD cord-009571-mygj2nd4 534 17 less less JJR cord-009571-mygj2nd4 534 18 than than IN cord-009571-mygj2nd4 534 19 half half NN cord-009571-mygj2nd4 534 20 of of IN cord-009571-mygj2nd4 534 21 the the DT cord-009571-mygj2nd4 534 22 maximum maximum JJ cord-009571-mygj2nd4 534 23 clearance clearance NN cord-009571-mygj2nd4 534 24 velocity velocity NN cord-009571-mygj2nd4 534 25 in in IN cord-009571-mygj2nd4 534 26 normal normal JJ cord-009571-mygj2nd4 534 27 mice mouse NNS cord-009571-mygj2nd4 534 28 . . . cord-009571-mygj2nd4 535 1 These these DT cord-009571-mygj2nd4 535 2 observations observation NNS cord-009571-mygj2nd4 535 3 indicate indicate VBP cord-009571-mygj2nd4 535 4 that that IN cord-009571-mygj2nd4 535 5 immune immune JJ cord-009571-mygj2nd4 535 6 complexes complex NNS cord-009571-mygj2nd4 535 7 alter alter VBP cord-009571-mygj2nd4 535 8 ssDNA ssdna JJ cord-009571-mygj2nd4 535 9 clearance clearance NN cord-009571-mygj2nd4 535 10 by by IN cord-009571-mygj2nd4 535 11 decreasing decrease VBG cord-009571-mygj2nd4 535 12 the the DT cord-009571-mygj2nd4 535 13 number number NN cord-009571-mygj2nd4 535 14 of of IN cord-009571-mygj2nd4 535 15 sites site NNS cord-009571-mygj2nd4 535 16 in in IN cord-009571-mygj2nd4 535 17 the the DT cord-009571-mygj2nd4 535 18 liver liver NN cord-009571-mygj2nd4 535 19 to to TO cord-009571-mygj2nd4 535 20 which which WDT cord-009571-mygj2nd4 535 21 DNA DNA NNP cord-009571-mygj2nd4 535 22 can can MD cord-009571-mygj2nd4 535 23 bind bind VB cord-009571-mygj2nd4 535 24 , , , cord-009571-mygj2nd4 535 25 or or CC cord-009571-mygj2nd4 535 26 by by IN cord-009571-mygj2nd4 535 27 decreasing decrease VBG cord-009571-mygj2nd4 535 28 access access NN cord-009571-mygj2nd4 535 29 of of IN cord-009571-mygj2nd4 535 30 DNA dna NN cord-009571-mygj2nd4 535 31 to to IN cord-009571-mygj2nd4 535 32 the the DT cord-009571-mygj2nd4 535 33 liver liver NN cord-009571-mygj2nd4 535 34 . . . cord-009571-mygj2nd4 536 1 By by IN cord-009571-mygj2nd4 536 2 altering alter VBG cord-009571-mygj2nd4 536 3 clearance clearance NN cord-009571-mygj2nd4 536 4 kinetics kinetic NNS cord-009571-mygj2nd4 536 5 , , , cord-009571-mygj2nd4 536 6 immune immune JJ cord-009571-mygj2nd4 536 7 complexes complex NNS cord-009571-mygj2nd4 536 8 may may MD cord-009571-mygj2nd4 536 9 contribute contribute VB cord-009571-mygj2nd4 536 10 to to IN cord-009571-mygj2nd4 536 11 the the DT cord-009571-mygj2nd4 536 12 persistence persistence NN cord-009571-mygj2nd4 536 13 of of IN cord-009571-mygj2nd4 536 14 DNA dna NN cord-009571-mygj2nd4 536 15 in in IN cord-009571-mygj2nd4 536 16 the the DT cord-009571-mygj2nd4 536 17 circulation circulation NN cord-009571-mygj2nd4 536 18 of of IN cord-009571-mygj2nd4 536 19 patients patient NNS cord-009571-mygj2nd4 536 20 with with IN cord-009571-mygj2nd4 536 21 SLE SLE NNP cord-009571-mygj2nd4 536 22 . . . cord-009571-mygj2nd4 537 1 ( ( -LRB- cord-009571-mygj2nd4 537 2 Supported support VBN cord-009571-mygj2nd4 537 3 by by IN cord-009571-mygj2nd4 537 4 NIH NIH NNP cord-009571-mygj2nd4 537 5 Grant Grant NNP cord-009571-mygj2nd4 537 6 AM11476 am11476 NN cord-009571-mygj2nd4 537 7 . . . cord-009571-mygj2nd4 537 8 ) ) -RRB- cord-009571-mygj2nd4 538 1 Rheumatoid rheumatoid JJ cord-009571-mygj2nd4 538 2 arthritis arthritis NN cord-009571-mygj2nd4 538 3 ( ( -LRB- cord-009571-mygj2nd4 538 4 RA RA NNP cord-009571-mygj2nd4 538 5 ) ) -RRB- cord-009571-mygj2nd4 538 6 frequently frequently RB cord-009571-mygj2nd4 538 7 affects affect VBZ cord-009571-mygj2nd4 538 8 the the DT cord-009571-mygj2nd4 538 9 wrist wrist NN cord-009571-mygj2nd4 538 10 , , , cord-009571-mygj2nd4 538 11 leading lead VBG cord-009571-mygj2nd4 538 12 to to IN cord-009571-mygj2nd4 538 13 pain pain NN cord-009571-mygj2nd4 538 14 , , , cord-009571-mygj2nd4 538 15 loss loss NN cord-009571-mygj2nd4 538 16 of of IN cord-009571-mygj2nd4 538 17 function function NN cord-009571-mygj2nd4 538 18 , , , cord-009571-mygj2nd4 538 19 and and CC cord-009571-mygj2nd4 538 20 destruction destruction NN cord-009571-mygj2nd4 538 21 of of IN cord-009571-mygj2nd4 538 22 normal normal JJ cord-009571-mygj2nd4 538 23 anatomy anatomy NN cord-009571-mygj2nd4 538 24 . . . cord-009571-mygj2nd4 539 1 Surgical surgical JJ cord-009571-mygj2nd4 539 2 treatment treatment NN cord-009571-mygj2nd4 539 3 by by IN cord-009571-mygj2nd4 539 4 synovectomy synovectomy NN cord-009571-mygj2nd4 539 5 alone alone RB cord-009571-mygj2nd4 539 6 does do VBZ cord-009571-mygj2nd4 539 7 not not RB cord-009571-mygj2nd4 539 8 correct correct VB cord-009571-mygj2nd4 539 9 carpal carpal NN cord-009571-mygj2nd4 539 10 deformities deformity NNS cord-009571-mygj2nd4 539 11 and and CC cord-009571-mygj2nd4 539 12 ulnar ulnar NN cord-009571-mygj2nd4 539 13 deviation deviation NN cord-009571-mygj2nd4 539 14 ; ; : cord-009571-mygj2nd4 539 15 fusion fusion NN cord-009571-mygj2nd4 539 16 of of IN cord-009571-mygj2nd4 539 17 the the DT cord-009571-mygj2nd4 539 18 wrist wrist NN cord-009571-mygj2nd4 539 19 , , , cord-009571-mygj2nd4 539 20 although although IN cord-009571-mygj2nd4 539 21 effective effective JJ cord-009571-mygj2nd4 539 22 in in IN cord-009571-mygj2nd4 539 23 reducing reduce VBG cord-009571-mygj2nd4 539 24 pain pain NN cord-009571-mygj2nd4 539 25 , , , cord-009571-mygj2nd4 539 26 severely severely RB cord-009571-mygj2nd4 539 27 limits limit VBZ cord-009571-mygj2nd4 539 28 function function NN cord-009571-mygj2nd4 539 29 . . . cord-009571-mygj2nd4 540 1 To to TO cord-009571-mygj2nd4 540 2 prevent prevent VB cord-009571-mygj2nd4 540 3 loss loss NN cord-009571-mygj2nd4 540 4 of of IN cord-009571-mygj2nd4 540 5 upper upper JJ cord-009571-mygj2nd4 540 6 extremity extremity NN cord-009571-mygj2nd4 540 7 function function NN cord-009571-mygj2nd4 540 8 while while IN cord-009571-mygj2nd4 540 9 simultaneously simultaneously RB cord-009571-mygj2nd4 540 10 correcting correct VBG cord-009571-mygj2nd4 540 11 deformities deformity NNS cord-009571-mygj2nd4 540 12 and and CC cord-009571-mygj2nd4 540 13 relieving relieve VBG cord-009571-mygj2nd4 540 14 pain pain NN cord-009571-mygj2nd4 540 15 , , , cord-009571-mygj2nd4 540 16 we -PRON- PRP cord-009571-mygj2nd4 540 17 combined combine VBD cord-009571-mygj2nd4 540 18 synovectomy synovectomy NN cord-009571-mygj2nd4 540 19 with with IN cord-009571-mygj2nd4 540 20 distal distal JJ cord-009571-mygj2nd4 540 21 ulnar ulnar JJ cord-009571-mygj2nd4 540 22 excision excision NN cord-009571-mygj2nd4 540 23 , , , cord-009571-mygj2nd4 540 24 correction correction NN cord-009571-mygj2nd4 540 25 of of IN cord-009571-mygj2nd4 540 26 carpal carpal NN cord-009571-mygj2nd4 540 27 supination supination NN cord-009571-mygj2nd4 540 28 - - HYPH cord-009571-mygj2nd4 540 29 subluxation subluxation NN cord-009571-mygj2nd4 540 30 , , , cord-009571-mygj2nd4 540 31 and and CC cord-009571-mygj2nd4 540 32 repair repair NN cord-009571-mygj2nd4 540 33 of of IN cord-009571-mygj2nd4 540 34 damaged damage VBN cord-009571-mygj2nd4 540 35 extensor extensor NN cord-009571-mygj2nd4 540 36 tendons tendon NNS cord-009571-mygj2nd4 540 37 . . . cord-009571-mygj2nd4 541 1 This this DT cord-009571-mygj2nd4 541 2 surgical surgical JJ cord-009571-mygj2nd4 541 3 stabilization stabilization NN cord-009571-mygj2nd4 541 4 approach approach NN cord-009571-mygj2nd4 541 5 was be VBD cord-009571-mygj2nd4 541 6 performed perform VBN cord-009571-mygj2nd4 541 7 61 61 CD cord-009571-mygj2nd4 541 8 times time NNS cord-009571-mygj2nd4 541 9 in in IN cord-009571-mygj2nd4 541 10 50 50 CD cord-009571-mygj2nd4 541 11 patients patient NNS cord-009571-mygj2nd4 541 12 with with IN cord-009571-mygj2nd4 541 13 RA RA NNP cord-009571-mygj2nd4 541 14 . . . cord-009571-mygj2nd4 542 1 All all DT cord-009571-mygj2nd4 542 2 had have VBD cord-009571-mygj2nd4 542 3 definite definite JJ cord-009571-mygj2nd4 542 4 or or CC cord-009571-mygj2nd4 542 5 classic classic JJ cord-009571-mygj2nd4 542 6 RA RA NNP cord-009571-mygj2nd4 542 7 and and CC cord-009571-mygj2nd4 542 8 had have VBD cord-009571-mygj2nd4 542 9 not not RB cord-009571-mygj2nd4 542 10 responded respond VBN cord-009571-mygj2nd4 542 11 to to IN cord-009571-mygj2nd4 542 12 aggressive aggressive JJ cord-009571-mygj2nd4 542 13 physiotherapy physiotherapy NN cord-009571-mygj2nd4 542 14 , , , cord-009571-mygj2nd4 542 15 including include VBG cord-009571-mygj2nd4 542 16 splints splint NNS cord-009571-mygj2nd4 542 17 and and CC cord-009571-mygj2nd4 542 18 local local JJ cord-009571-mygj2nd4 542 19 and and CC cord-009571-mygj2nd4 542 20 systemic systemic JJ cord-009571-mygj2nd4 542 21 medications medication NNS cord-009571-mygj2nd4 542 22 . . . cord-009571-mygj2nd4 543 1 All all DT cord-009571-mygj2nd4 543 2 had have VBD cord-009571-mygj2nd4 543 3 synovitis synovitis JJ cord-009571-mygj2nd4 543 4 with with IN cord-009571-mygj2nd4 543 5 deformity deformity NN cord-009571-mygj2nd4 543 6 and and CC cord-009571-mygj2nd4 543 7 instability instability NN cord-009571-mygj2nd4 543 8 . . . cord-009571-mygj2nd4 544 1 The the DT cord-009571-mygj2nd4 544 2 deformity deformity NN cord-009571-mygj2nd4 544 3 most most RBS cord-009571-mygj2nd4 544 4 commonly commonly RB cord-009571-mygj2nd4 544 5 seen see VBN cord-009571-mygj2nd4 544 6 was be VBD cord-009571-mygj2nd4 544 7 carpal carpal NN cord-009571-mygj2nd4 544 8 supination supination NN cord-009571-mygj2nd4 544 9 - - HYPH cord-009571-mygj2nd4 544 10 subluxation subluxation NN cord-009571-mygj2nd4 544 11 with with IN cord-009571-mygj2nd4 544 12 relative relative JJ cord-009571-mygj2nd4 544 13 prominence prominence NN cord-009571-mygj2nd4 544 14 of of IN cord-009571-mygj2nd4 544 15 the the DT cord-009571-mygj2nd4 544 16 distal distal JJ cord-009571-mygj2nd4 544 17 ulna ulna NN cord-009571-mygj2nd4 544 18 . . . cord-009571-mygj2nd4 545 1 The the DT cord-009571-mygj2nd4 545 2 primary primary JJ cord-009571-mygj2nd4 545 3 reasons reason NNS cord-009571-mygj2nd4 545 4 for for IN cord-009571-mygj2nd4 545 5 operation operation NN cord-009571-mygj2nd4 545 6 were be VBD cord-009571-mygj2nd4 545 7 frank frank JJ cord-009571-mygj2nd4 545 8 ( ( -LRB- cord-009571-mygj2nd4 545 9 23 23 CD cord-009571-mygj2nd4 545 10 ) ) -RRB- cord-009571-mygj2nd4 545 11 or or CC cord-009571-mygj2nd4 545 12 potential potential JJ cord-009571-mygj2nd4 545 13 tendon tendon NN cord-009571-mygj2nd4 545 14 rupture rupture NN cord-009571-mygj2nd4 545 15 ( ( -LRB- cord-009571-mygj2nd4 545 16 3 3 CD cord-009571-mygj2nd4 545 17 ) ) -RRB- cord-009571-mygj2nd4 545 18 , , , cord-009571-mygj2nd4 545 19 persistent persistent JJ cord-009571-mygj2nd4 545 20 synovitis synovitis NNP cord-009571-mygj2nd4 545 21 with with IN cord-009571-mygj2nd4 545 22 pain pain NN cord-009571-mygj2nd4 545 23 at at IN cord-009571-mygj2nd4 545 24 rest rest NN cord-009571-mygj2nd4 545 25 ( ( -LRB- cord-009571-mygj2nd4 545 26 21 21 CD cord-009571-mygj2nd4 545 27 ) ) -RRB- cord-009571-mygj2nd4 545 28 , , , cord-009571-mygj2nd4 545 29 and and CC cord-009571-mygj2nd4 545 30 pain pain NN cord-009571-mygj2nd4 545 31 with with IN cord-009571-mygj2nd4 545 32 significant significant JJ cord-009571-mygj2nd4 545 33 deformity deformity NN cord-009571-mygj2nd4 545 34 ( ( -LRB- cord-009571-mygj2nd4 545 35 14 14 CD cord-009571-mygj2nd4 545 36 ) ) -RRB- cord-009571-mygj2nd4 545 37 . . . cord-009571-mygj2nd4 546 1 The the DT cord-009571-mygj2nd4 546 2 mean mean JJ cord-009571-mygj2nd4 546 3 age age NN cord-009571-mygj2nd4 546 4 was be VBD cord-009571-mygj2nd4 546 5 48 48 CD cord-009571-mygj2nd4 546 6 years year NNS cord-009571-mygj2nd4 547 1 ( ( -LRB- cord-009571-mygj2nd4 547 2 range range NN cord-009571-mygj2nd4 547 3 : : : cord-009571-mygj2nd4 547 4 21 21 CD cord-009571-mygj2nd4 547 5 - - SYM cord-009571-mygj2nd4 547 6 76 76 CD cord-009571-mygj2nd4 547 7 ) ) -RRB- cord-009571-mygj2nd4 547 8 . . . cord-009571-mygj2nd4 548 1 The the DT cord-009571-mygj2nd4 548 2 wrist wrist NN cord-009571-mygj2nd4 548 3 was be VBD cord-009571-mygj2nd4 548 4 exposed expose VBN cord-009571-mygj2nd4 548 5 with with IN cord-009571-mygj2nd4 548 6 preservation preservation NN cord-009571-mygj2nd4 548 7 of of IN cord-009571-mygj2nd4 548 8 the the DT cord-009571-mygj2nd4 548 9 exten exten NN cord-009571-mygj2nd4 548 10 - - HYPH cord-009571-mygj2nd4 548 11 sor sor NNP cord-009571-mygj2nd4 548 12 retinaculum retinaculum NN cord-009571-mygj2nd4 548 13 . . . cord-009571-mygj2nd4 549 1 Following follow VBG cord-009571-mygj2nd4 549 2 excision excision NN cord-009571-mygj2nd4 549 3 of of IN cord-009571-mygj2nd4 549 4 the the DT cord-009571-mygj2nd4 549 5 distal distal JJ cord-009571-mygj2nd4 549 6 ulna ulna NN cord-009571-mygj2nd4 549 7 , , , cord-009571-mygj2nd4 549 8 a a DT cord-009571-mygj2nd4 549 9 synovectomy synovectomy NN cord-009571-mygj2nd4 549 10 of of IN cord-009571-mygj2nd4 549 11 the the DT cord-009571-mygj2nd4 549 12 radiocarpal radiocarpal JJ cord-009571-mygj2nd4 549 13 and and CC cord-009571-mygj2nd4 549 14 intercarpal intercarpal JJ cord-009571-mygj2nd4 549 15 joints joint NNS cord-009571-mygj2nd4 549 16 was be VBD cord-009571-mygj2nd4 549 17 carried carry VBN cord-009571-mygj2nd4 549 18 out out RP cord-009571-mygj2nd4 549 19 . . . cord-009571-mygj2nd4 550 1 Any any DT cord-009571-mygj2nd4 550 2 existing exist VBG cord-009571-mygj2nd4 550 3 carpal carpal NN cord-009571-mygj2nd4 550 4 dissociations dissociation NNS cord-009571-mygj2nd4 550 5 were be VBD cord-009571-mygj2nd4 550 6 realigned realign VBN cord-009571-mygj2nd4 550 7 , , , cord-009571-mygj2nd4 550 8 and and CC cord-009571-mygj2nd4 550 9 the the DT cord-009571-mygj2nd4 550 10 carpal carpal NN cord-009571-mygj2nd4 550 11 supination supination NN cord-009571-mygj2nd4 550 12 - - HYPH cord-009571-mygj2nd4 550 13 subluxation subluxation NN cord-009571-mygj2nd4 550 14 deformity deformity NN cord-009571-mygj2nd4 550 15 was be VBD cord-009571-mygj2nd4 550 16 corrected correct VBN cord-009571-mygj2nd4 550 17 by by IN cord-009571-mygj2nd4 550 18 placing place VBG cord-009571-mygj2nd4 550 19 the the DT cord-009571-mygj2nd4 550 20 wrist wrist NN cord-009571-mygj2nd4 550 21 in in IN cord-009571-mygj2nd4 550 22 pronation pronation NN cord-009571-mygj2nd4 550 23 and and CC cord-009571-mygj2nd4 550 24 reconstructing reconstruct VBG cord-009571-mygj2nd4 550 25 the the DT cord-009571-mygj2nd4 550 26 triangular triangular JJ cord-009571-mygj2nd4 550 27 ligament ligament NN cord-009571-mygj2nd4 550 28 using use VBG cord-009571-mygj2nd4 550 29 the the DT cord-009571-mygj2nd4 550 30 volar volar JJ cord-009571-mygj2nd4 550 31 capsule capsule NN cord-009571-mygj2nd4 550 32 . . . cord-009571-mygj2nd4 551 1 Extensor extensor JJ cord-009571-mygj2nd4 551 2 tendon tendon NN cord-009571-mygj2nd4 551 3 repair repair NN cord-009571-mygj2nd4 551 4 and and CC cord-009571-mygj2nd4 551 5 grafting grafting NN cord-009571-mygj2nd4 551 6 were be VBD cord-009571-mygj2nd4 551 7 then then RB cord-009571-mygj2nd4 551 8 carried carry VBN cord-009571-mygj2nd4 551 9 out out RP cord-009571-mygj2nd4 551 10 . . . cord-009571-mygj2nd4 552 1 Length length NN cord-009571-mygj2nd4 552 2 of of IN cord-009571-mygj2nd4 552 3 followup followup NN cord-009571-mygj2nd4 552 4 was be VBD cord-009571-mygj2nd4 552 5 30 30 CD cord-009571-mygj2nd4 552 6 months month NNS cord-009571-mygj2nd4 552 7 with with IN cord-009571-mygj2nd4 552 8 a a DT cord-009571-mygj2nd4 552 9 range range NN cord-009571-mygj2nd4 552 10 of of IN cord-009571-mygj2nd4 552 11 1 1 CD cord-009571-mygj2nd4 552 12 - - SYM cord-009571-mygj2nd4 552 13 8 8 CD cord-009571-mygj2nd4 552 14 years year NNS cord-009571-mygj2nd4 552 15 . . . cord-009571-mygj2nd4 553 1 Results result NNS cord-009571-mygj2nd4 553 2 were be VBD cord-009571-mygj2nd4 553 3 classified classify VBN cord-009571-mygj2nd4 553 4 as as RB cord-009571-mygj2nd4 553 5 good good JJ cord-009571-mygj2nd4 553 6 if if IN cord-009571-mygj2nd4 553 7 the the DT cord-009571-mygj2nd4 553 8 patient patient NN cord-009571-mygj2nd4 553 9 was be VBD cord-009571-mygj2nd4 553 10 satisfied satisfied JJ cord-009571-mygj2nd4 553 11 , , , cord-009571-mygj2nd4 553 12 had have VBD cord-009571-mygj2nd4 553 13 only only RB cord-009571-mygj2nd4 553 14 occasional occasional JJ cord-009571-mygj2nd4 553 15 pain pain NN cord-009571-mygj2nd4 553 16 , , , cord-009571-mygj2nd4 553 17 a a DT cord-009571-mygj2nd4 553 18 stable stable JJ cord-009571-mygj2nd4 553 19 wrist wrist NN cord-009571-mygj2nd4 553 20 , , , cord-009571-mygj2nd4 553 21 and and CC cord-009571-mygj2nd4 553 22 no no DT cord-009571-mygj2nd4 553 23 recurrence recurrence NN cord-009571-mygj2nd4 553 24 of of IN cord-009571-mygj2nd4 553 25 synovitis synovitis NN cord-009571-mygj2nd4 553 26 . . . cord-009571-mygj2nd4 554 1 Three three CD cord-009571-mygj2nd4 554 2 patients patient NNS cord-009571-mygj2nd4 554 3 were be VBD cord-009571-mygj2nd4 554 4 lost lose VBN cord-009571-mygj2nd4 554 5 to to IN cord-009571-mygj2nd4 554 6 followup followup VB cord-009571-mygj2nd4 554 7 and and CC cord-009571-mygj2nd4 554 8 of of IN cord-009571-mygj2nd4 554 9 the the DT cord-009571-mygj2nd4 554 10 remaining remain VBG cord-009571-mygj2nd4 554 11 58 58 CD cord-009571-mygj2nd4 554 12 , , , cord-009571-mygj2nd4 554 13 good good JJ cord-009571-mygj2nd4 554 14 results result NNS cord-009571-mygj2nd4 554 15 were be VBD cord-009571-mygj2nd4 554 16 obtained obtain VBN cord-009571-mygj2nd4 554 17 in in IN cord-009571-mygj2nd4 554 18 42 42 CD cord-009571-mygj2nd4 554 19 . . . cord-009571-mygj2nd4 555 1 An an DT cord-009571-mygj2nd4 555 2 additional additional JJ cord-009571-mygj2nd4 555 3 12 12 CD cord-009571-mygj2nd4 555 4 had have VBD cord-009571-mygj2nd4 555 5 objective objective JJ cord-009571-mygj2nd4 555 6 improvement improvement NN cord-009571-mygj2nd4 555 7 but but CC cord-009571-mygj2nd4 555 8 experienced experienced JJ cord-009571-mygj2nd4 555 9 recurrence recurrence NN cord-009571-mygj2nd4 555 10 of of IN cord-009571-mygj2nd4 555 11 synovitis synovitis NN cord-009571-mygj2nd4 555 12 and and CC cord-009571-mygj2nd4 555 13 pain pain NN cord-009571-mygj2nd4 555 14 and and CC cord-009571-mygj2nd4 555 15 an an DT cord-009571-mygj2nd4 555 16 extensor extensor NN cord-009571-mygj2nd4 555 17 lag lag NN cord-009571-mygj2nd4 555 18 of of IN cord-009571-mygj2nd4 555 19 up up IN cord-009571-mygj2nd4 555 20 to to TO cord-009571-mygj2nd4 555 21 1 1 CD cord-009571-mygj2nd4 555 22 5 5 CD cord-009571-mygj2nd4 555 23 O o NN cord-009571-mygj2nd4 555 24 . . . cord-009571-mygj2nd4 556 1 Less less RBR cord-009571-mygj2nd4 556 2 satisfactory satisfactory JJ cord-009571-mygj2nd4 556 3 improvement improvement NN cord-009571-mygj2nd4 556 4 was be VBD cord-009571-mygj2nd4 556 5 found find VBN cord-009571-mygj2nd4 556 6 in in IN cord-009571-mygj2nd4 556 7 4 4 CD cord-009571-mygj2nd4 556 8 of of IN cord-009571-mygj2nd4 556 9 the the DT cord-009571-mygj2nd4 556 10 58 58 CD cord-009571-mygj2nd4 556 11 . . . cord-009571-mygj2nd4 557 1 The the DT cord-009571-mygj2nd4 557 2 average average JJ cord-009571-mygj2nd4 557 3 loss loss NN cord-009571-mygj2nd4 557 4 of of IN cord-009571-mygj2nd4 557 5 motion motion NN cord-009571-mygj2nd4 557 6 was be VBD cord-009571-mygj2nd4 557 7 47'37 47'37 CD cord-009571-mygj2nd4 557 8 , , , cord-009571-mygj2nd4 557 9 leaving leave VBG cord-009571-mygj2nd4 557 10 patients patient NNS cord-009571-mygj2nd4 557 11 with with IN cord-009571-mygj2nd4 557 12 a a DT cord-009571-mygj2nd4 557 13 combined combine VBN cord-009571-mygj2nd4 557 14 palmar palmar NN cord-009571-mygj2nd4 557 15 and and CC cord-009571-mygj2nd4 557 16 dorsiflexion dorsiflexion NN cord-009571-mygj2nd4 557 17 range range NN cord-009571-mygj2nd4 557 18 of of IN cord-009571-mygj2nd4 557 19 42 42 CD cord-009571-mygj2nd4 557 20 " " '' cord-009571-mygj2nd4 557 21 . . . cord-009571-mygj2nd4 558 1 Although although IN cord-009571-mygj2nd4 558 2 this this DT cord-009571-mygj2nd4 558 3 stabilization stabilization NN cord-009571-mygj2nd4 558 4 procedure procedure NN cord-009571-mygj2nd4 558 5 is be VBZ cord-009571-mygj2nd4 558 6 not not RB cord-009571-mygj2nd4 558 7 considered consider VBN cord-009571-mygj2nd4 558 8 appropriate appropriate JJ cord-009571-mygj2nd4 558 9 for for IN cord-009571-mygj2nd4 558 10 the the DT cord-009571-mygj2nd4 558 11 severely severely RB cord-009571-mygj2nd4 558 12 destroyed destroy VBN cord-009571-mygj2nd4 558 13 wrist wrist NN cord-009571-mygj2nd4 558 14 , , , cord-009571-mygj2nd4 558 15 the the DT cord-009571-mygj2nd4 558 16 overall overall JJ cord-009571-mygj2nd4 558 17 900/0 900/0 CD cord-009571-mygj2nd4 558 18 improvement improvement NN cord-009571-mygj2nd4 558 19 ( ( -LRB- cord-009571-mygj2nd4 558 20 fair fair JJ cord-009571-mygj2nd4 558 21 and and CC cord-009571-mygj2nd4 558 22 good good JJ cord-009571-mygj2nd4 558 23 results result NNS cord-009571-mygj2nd4 558 24 ) ) -RRB- cord-009571-mygj2nd4 558 25 justifies justify VBZ cord-009571-mygj2nd4 558 26 its -PRON- PRP$ cord-009571-mygj2nd4 558 27 consideration consideration NN cord-009571-mygj2nd4 558 28 in in IN cord-009571-mygj2nd4 558 29 preference preference NN cord-009571-mygj2nd4 558 30 to to IN cord-009571-mygj2nd4 558 31 either either CC cord-009571-mygj2nd4 558 32 synovectomy synovectomy NN cord-009571-mygj2nd4 558 33 or or CC cord-009571-mygj2nd4 558 34 wrist wrist NN cord-009571-mygj2nd4 558 35 fusion fusion NN cord-009571-mygj2nd4 558 36 alone alone RB cord-009571-mygj2nd4 558 37 . . . cord-009571-mygj2nd4 559 1 The the DT cord-009571-mygj2nd4 559 2 destructive destructive JJ cord-009571-mygj2nd4 559 3 inflammation inflammation NN cord-009571-mygj2nd4 559 4 observed observe VBN cord-009571-mygj2nd4 559 5 in in IN cord-009571-mygj2nd4 559 6 synovia synovia NNP cord-009571-mygj2nd4 559 7 of of IN cord-009571-mygj2nd4 559 8 rheumatoid rheumatoid NN cord-009571-mygj2nd4 559 9 joints joint NNS cord-009571-mygj2nd4 559 10 may may MD cord-009571-mygj2nd4 559 11 be be VB cord-009571-mygj2nd4 559 12 largely largely RB cord-009571-mygj2nd4 559 13 due due JJ cord-009571-mygj2nd4 559 14 to to IN cord-009571-mygj2nd4 559 15 autoimmune autoimmune JJ cord-009571-mygj2nd4 559 16 processes process NNS cord-009571-mygj2nd4 559 17 . . . cord-009571-mygj2nd4 560 1 Antibodies antibody NNS cord-009571-mygj2nd4 560 2 to to IN cord-009571-mygj2nd4 560 3 types type NNS cord-009571-mygj2nd4 560 4 I -PRON- PRP cord-009571-mygj2nd4 560 5 , , , cord-009571-mygj2nd4 560 6 11 11 CD cord-009571-mygj2nd4 560 7 , , , cord-009571-mygj2nd4 560 8 111 111 CD cord-009571-mygj2nd4 560 9 collagens collagen NNS cord-009571-mygj2nd4 560 10 have have VBP cord-009571-mygj2nd4 560 11 previously previously RB cord-009571-mygj2nd4 560 12 been be VBN cord-009571-mygj2nd4 560 13 detected detect VBN cord-009571-mygj2nd4 560 14 in in IN cord-009571-mygj2nd4 560 15 joint joint JJ cord-009571-mygj2nd4 560 16 fluids fluid NNS cord-009571-mygj2nd4 560 17 of of IN cord-009571-mygj2nd4 560 18 rheumatoid rheumatoid NN cord-009571-mygj2nd4 560 19 patients patient NNS cord-009571-mygj2nd4 560 20 and and CC cord-009571-mygj2nd4 560 21 cellassociated cellassociate VBN cord-009571-mygj2nd4 560 22 antibodies antibody NNS cord-009571-mygj2nd4 560 23 which which WDT cord-009571-mygj2nd4 560 24 react react VBP cord-009571-mygj2nd4 560 25 only only RB cord-009571-mygj2nd4 560 26 with with IN cord-009571-mygj2nd4 560 27 cartilage cartilage NN cord-009571-mygj2nd4 560 28 type type NN cord-009571-mygj2nd4 560 29 I1 i1 NN cord-009571-mygj2nd4 560 30 collagen collagen NN cord-009571-mygj2nd4 560 31 can can MD cord-009571-mygj2nd4 560 32 be be VB cord-009571-mygj2nd4 560 33 locally locally RB cord-009571-mygj2nd4 560 34 detected detect VBN cord-009571-mygj2nd4 560 35 in in IN cord-009571-mygj2nd4 560 36 inflamed inflamed JJ cord-009571-mygj2nd4 560 37 rheumatoid rheumatoid NN cord-009571-mygj2nd4 560 38 synovia synovia NN cord-009571-mygj2nd4 560 39 . . . cord-009571-mygj2nd4 561 1 We -PRON- PRP cord-009571-mygj2nd4 561 2 are be VBP cord-009571-mygj2nd4 561 3 interested interested JJ cord-009571-mygj2nd4 561 4 in in IN cord-009571-mygj2nd4 561 5 finding find VBG cord-009571-mygj2nd4 561 6 evidence evidence NN cord-009571-mygj2nd4 561 7 for for IN cord-009571-mygj2nd4 561 8 cell cell NN cord-009571-mygj2nd4 561 9 - - HYPH cord-009571-mygj2nd4 561 10 mediated mediate VBN cord-009571-mygj2nd4 561 11 immunity immunity NN cord-009571-mygj2nd4 561 12 to to IN cord-009571-mygj2nd4 561 13 collagen collagen NN cord-009571-mygj2nd4 561 14 . . . cord-009571-mygj2nd4 562 1 Immune immune JJ cord-009571-mygj2nd4 562 2 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 562 3 challenged challenge VBN cord-009571-mygj2nd4 562 4 with with IN cord-009571-mygj2nd4 562 5 antigen antigen NN cord-009571-mygj2nd4 562 6 produce produce NN cord-009571-mygj2nd4 562 7 substances substance NNS cord-009571-mygj2nd4 562 8 ( ( -LRB- cord-009571-mygj2nd4 562 9 lymphokines lymphokine NNS cord-009571-mygj2nd4 562 10 ) ) -RRB- cord-009571-mygj2nd4 562 11 that that WDT cord-009571-mygj2nd4 562 12 can can MD cord-009571-mygj2nd4 562 13 grossly grossly RB cord-009571-mygj2nd4 562 14 stimulate stimulate VB cord-009571-mygj2nd4 562 15 the the DT cord-009571-mygj2nd4 562 16 secretion secretion NN cord-009571-mygj2nd4 562 17 of of IN cord-009571-mygj2nd4 562 18 the the DT cord-009571-mygj2nd4 562 19 enzyme enzyme NN cord-009571-mygj2nd4 562 20 collagenase collagenase NN cord-009571-mygj2nd4 562 21 from from IN cord-009571-mygj2nd4 562 22 macrophages macrophage NNS cord-009571-mygj2nd4 562 23 . . . cord-009571-mygj2nd4 563 1 Collagenase Collagenase NNP cord-009571-mygj2nd4 563 2 , , , cord-009571-mygj2nd4 563 3 which which WDT cord-009571-mygj2nd4 563 4 can can MD cord-009571-mygj2nd4 563 5 degrade degrade VB cord-009571-mygj2nd4 563 6 cartilage cartilage NN cord-009571-mygj2nd4 563 7 collagen collagen NN cord-009571-mygj2nd4 563 8 producing produce VBG cord-009571-mygj2nd4 563 9 cartilage cartilage NN cord-009571-mygj2nd4 563 10 destruction destruction NN cord-009571-mygj2nd4 563 11 , , , cord-009571-mygj2nd4 563 12 is be VBZ cord-009571-mygj2nd4 563 13 also also RB cord-009571-mygj2nd4 563 14 secreted secrete VBN cord-009571-mygj2nd4 563 15 by by IN cord-009571-mygj2nd4 563 16 macrophage macrophage NN cord-009571-mygj2nd4 563 17 - - HYPH cord-009571-mygj2nd4 563 18 like like JJ cord-009571-mygj2nd4 563 19 cells cell NNS cord-009571-mygj2nd4 563 20 in in IN cord-009571-mygj2nd4 563 21 rheumatoid rheumatoid NN cord-009571-mygj2nd4 563 22 synovia synovia NNP cord-009571-mygj2nd4 563 23 and and CC cord-009571-mygj2nd4 563 24 its -PRON- PRP$ cord-009571-mygj2nd4 563 25 secretion secretion NN cord-009571-mygj2nd4 563 26 can can MD cord-009571-mygj2nd4 563 27 be be VB cord-009571-mygj2nd4 563 28 stimulated stimulate VBN cord-009571-mygj2nd4 563 29 from from IN cord-009571-mygj2nd4 563 30 synovial synovial JJ cord-009571-mygj2nd4 563 31 cells cell NNS cord-009571-mygj2nd4 563 32 by by IN cord-009571-mygj2nd4 563 33 a a DT cord-009571-mygj2nd4 563 34 factor(s factor(s NNP cord-009571-mygj2nd4 563 35 ) ) -RRB- cord-009571-mygj2nd4 563 36 produced produce VBN cord-009571-mygj2nd4 563 37 by by IN cord-009571-mygj2nd4 563 38 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 563 39 , , , cord-009571-mygj2nd4 563 40 unstimulated unstimulated JJ cord-009571-mygj2nd4 563 41 or or CC cord-009571-mygj2nd4 563 42 stimulated stimulate VBN cord-009571-mygj2nd4 563 43 with with IN cord-009571-mygj2nd4 563 44 phytohemagglutinin phytohemagglutinin NNS cord-009571-mygj2nd4 563 45 . . . cord-009571-mygj2nd4 564 1 In in IN cord-009571-mygj2nd4 564 2 the the DT cord-009571-mygj2nd4 564 3 present present JJ cord-009571-mygj2nd4 564 4 study study NN cord-009571-mygj2nd4 564 5 inflamed inflamed JJ cord-009571-mygj2nd4 564 6 synovia synovia NNS cord-009571-mygj2nd4 564 7 were be VBD cord-009571-mygj2nd4 564 8 removed remove VBN cord-009571-mygj2nd4 564 9 at at IN cord-009571-mygj2nd4 564 10 surgery surgery NN cord-009571-mygj2nd4 564 11 from from IN cord-009571-mygj2nd4 564 12 9 9 CD cord-009571-mygj2nd4 564 13 patients patient NNS cord-009571-mygj2nd4 564 14 with with IN cord-009571-mygj2nd4 564 15 classic classic JJ cord-009571-mygj2nd4 564 16 rheumatoid rheumatoid NN cord-009571-mygj2nd4 564 17 arthritis arthritis NN cord-009571-mygj2nd4 564 18 . . . cord-009571-mygj2nd4 565 1 Synovial synovial JJ cord-009571-mygj2nd4 565 2 fragments fragment NNS cord-009571-mygj2nd4 565 3 were be VBD cord-009571-mygj2nd4 565 4 maintained maintain VBN cord-009571-mygj2nd4 565 5 in in IN cord-009571-mygj2nd4 565 6 a a DT cord-009571-mygj2nd4 565 7 viable viable JJ cord-009571-mygj2nd4 565 8 state state NN cord-009571-mygj2nd4 565 9 in in IN cord-009571-mygj2nd4 565 10 organ organ NN cord-009571-mygj2nd4 565 11 culture culture NN cord-009571-mygj2nd4 565 12 for for IN cord-009571-mygj2nd4 565 13 up up RP cord-009571-mygj2nd4 565 14 t t NN cord-009571-mygj2nd4 565 15 o o NN cord-009571-mygj2nd4 565 16 2 2 CD cord-009571-mygj2nd4 565 17 weeks week NNS cord-009571-mygj2nd4 565 18 . . . cord-009571-mygj2nd4 566 1 Culture culture NN cord-009571-mygj2nd4 566 2 media medium NNS cord-009571-mygj2nd4 566 3 were be VBD cord-009571-mygj2nd4 566 4 changed change VBN cord-009571-mygj2nd4 566 5 every every DT cord-009571-mygj2nd4 566 6 2 2 CD cord-009571-mygj2nd4 566 7 days day NNS cord-009571-mygj2nd4 566 8 and and CC cord-009571-mygj2nd4 566 9 the the DT cord-009571-mygj2nd4 566 10 collagenase collagenase NNP cord-009571-mygj2nd4 566 11 secreted secrete VBD cord-009571-mygj2nd4 566 12 into into IN cord-009571-mygj2nd4 566 13 the the DT cord-009571-mygj2nd4 566 14 culture culture NN cord-009571-mygj2nd4 566 15 medium medium NN cord-009571-mygj2nd4 566 16 was be VBD cord-009571-mygj2nd4 566 17 assayed assay VBN cord-009571-mygj2nd4 566 18 . . . cord-009571-mygj2nd4 567 1 To to IN cord-009571-mygj2nd4 567 2 these these DT cord-009571-mygj2nd4 567 3 cultures culture NNS cord-009571-mygj2nd4 567 4 were be VBD cord-009571-mygj2nd4 567 5 added add VBN cord-009571-mygj2nd4 567 6 type type NN cord-009571-mygj2nd4 567 7 I -PRON- PRP cord-009571-mygj2nd4 567 8 or or CC cord-009571-mygj2nd4 567 9 type type VB cord-009571-mygj2nd4 567 10 11 11 CD cord-009571-mygj2nd4 567 11 collagen collagen NN cord-009571-mygj2nd4 567 12 in in IN cord-009571-mygj2nd4 567 13 the the DT cord-009571-mygj2nd4 567 14 form form NN cord-009571-mygj2nd4 567 15 of of IN cord-009571-mygj2nd4 567 16 diffusible diffusible NN cord-009571-mygj2nd4 567 17 immunologically immunologically RB cord-009571-mygj2nd4 567 18 active active JJ cord-009571-mygj2nd4 567 19 fragments fragment NNS cord-009571-mygj2nd4 567 20 prepared prepare VBN cord-009571-mygj2nd4 567 21 by by IN cord-009571-mygj2nd4 567 22 cyanogen cyanogen NN cord-009571-mygj2nd4 567 23 bromide bromide NN cord-009571-mygj2nd4 567 24 cleavage cleavage NN cord-009571-mygj2nd4 567 25 of of IN cord-009571-mygj2nd4 567 26 native native JJ cord-009571-mygj2nd4 567 27 collagen collagen NN cord-009571-mygj2nd4 567 28 . . . cord-009571-mygj2nd4 568 1 In in IN cord-009571-mygj2nd4 568 2 3 3 CD cord-009571-mygj2nd4 568 3 of of IN cord-009571-mygj2nd4 568 4 9 9 CD cord-009571-mygj2nd4 568 5 rheumatoid rheumatoid NN cord-009571-mygj2nd4 568 6 patients patient NNS cord-009571-mygj2nd4 568 7 , , , cord-009571-mygj2nd4 568 8 the the DT cord-009571-mygj2nd4 568 9 addition addition NN cord-009571-mygj2nd4 568 10 of of IN cord-009571-mygj2nd4 568 11 type type NN cord-009571-mygj2nd4 568 12 I1 i1 NN cord-009571-mygj2nd4 568 13 collagen collagen NN cord-009571-mygj2nd4 568 14 fragments fragment NNS cord-009571-mygj2nd4 568 15 resulted result VBD cord-009571-mygj2nd4 568 16 in in IN cord-009571-mygj2nd4 568 17 a a DT cord-009571-mygj2nd4 568 18 significant significant JJ cord-009571-mygj2nd4 568 19 increase increase NN cord-009571-mygj2nd4 568 20 in in IN cord-009571-mygj2nd4 568 21 collagenase collagenase JJ cord-009571-mygj2nd4 568 22 secretion secretion NN cord-009571-mygj2nd4 568 23 compared compare VBN cord-009571-mygj2nd4 568 24 with with IN cord-009571-mygj2nd4 568 25 explants explant NNS cord-009571-mygj2nd4 568 26 which which WDT cord-009571-mygj2nd4 568 27 had have VBD cord-009571-mygj2nd4 568 28 not not RB cord-009571-mygj2nd4 568 29 been be VBN cord-009571-mygj2nd4 568 30 stimulated stimulate VBN cord-009571-mygj2nd4 568 31 : : : cord-009571-mygj2nd4 568 32 artificial artificial JJ cord-009571-mygj2nd4 568 33 stimulation stimulation NN cord-009571-mygj2nd4 568 34 of of IN cord-009571-mygj2nd4 568 35 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 568 36 in in IN cord-009571-mygj2nd4 568 37 these these DT cord-009571-mygj2nd4 568 38 explants explant NNS cord-009571-mygj2nd4 568 39 with with IN cord-009571-mygj2nd4 568 40 phytohemagglutinin phytohemagglutinin NNP cord-009571-mygj2nd4 568 41 also also RB cord-009571-mygj2nd4 568 42 resulted result VBD cord-009571-mygj2nd4 568 43 in in IN cord-009571-mygj2nd4 568 44 a a DT cord-009571-mygj2nd4 568 45 similar similar JJ cord-009571-mygj2nd4 568 46 increase increase NN cord-009571-mygj2nd4 568 47 in in IN cord-009571-mygj2nd4 568 48 collagenase collagenase JJ cord-009571-mygj2nd4 568 49 secretion secretion NN cord-009571-mygj2nd4 568 50 . . . cord-009571-mygj2nd4 569 1 Type type NN cord-009571-mygj2nd4 569 2 I -PRON- PRP cord-009571-mygj2nd4 569 3 collagen collagen NN cord-009571-mygj2nd4 569 4 peptides peptide NNS cord-009571-mygj2nd4 569 5 had have VBD cord-009571-mygj2nd4 569 6 no no DT cord-009571-mygj2nd4 569 7 stimulatory stimulatory JJ cord-009571-mygj2nd4 569 8 effect effect NN cord-009571-mygj2nd4 569 9 . . . cord-009571-mygj2nd4 570 1 These these DT cord-009571-mygj2nd4 570 2 results result NNS cord-009571-mygj2nd4 570 3 support support VBP cord-009571-mygj2nd4 570 4 the the DT cord-009571-mygj2nd4 570 5 thesis thesis NN cord-009571-mygj2nd4 570 6 that that IN cord-009571-mygj2nd4 570 7 in in IN cord-009571-mygj2nd4 570 8 some some DT cord-009571-mygj2nd4 570 9 patients patient NNS cord-009571-mygj2nd4 570 10 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 570 11 synovia synovia NN cord-009571-mygj2nd4 570 12 contain contain VBP cord-009571-mygj2nd4 570 13 immune immune JJ cord-009571-mygj2nd4 570 14 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 570 15 which which WDT cord-009571-mygj2nd4 570 16 can can MD cord-009571-mygj2nd4 570 17 respond respond VB cord-009571-mygj2nd4 570 18 t t NN cord-009571-mygj2nd4 570 19 o o NN cord-009571-mygj2nd4 570 20 type type NN cord-009571-mygj2nd4 570 21 I1 i1 NN cord-009571-mygj2nd4 570 22 collagen collagen NN cord-009571-mygj2nd4 570 23 peptides peptide NNS cord-009571-mygj2nd4 570 24 produced produce VBN cord-009571-mygj2nd4 570 25 by by IN cord-009571-mygj2nd4 570 26 degradation degradation NN cord-009571-mygj2nd4 570 27 of of IN cord-009571-mygj2nd4 570 28 hyaline hyaline JJ cord-009571-mygj2nd4 570 29 cartilage cartilage NN cord-009571-mygj2nd4 570 30 collagen collagen NN cord-009571-mygj2nd4 570 31 . . . cord-009571-mygj2nd4 571 1 When when WRB cord-009571-mygj2nd4 571 2 challenged challenge VBN cord-009571-mygj2nd4 571 3 with with IN cord-009571-mygj2nd4 571 4 antigen antigen NN cord-009571-mygj2nd4 571 5 , , , cord-009571-mygj2nd4 571 6 these these DT cord-009571-mygj2nd4 571 7 cells cell NNS cord-009571-mygj2nd4 571 8 may may MD cord-009571-mygj2nd4 571 9 produce produce VB cord-009571-mygj2nd4 571 10 factors factor NNS cord-009571-mygj2nd4 571 11 that that WDT cord-009571-mygj2nd4 571 12 stimulate stimulate VBP cord-009571-mygj2nd4 571 13 the the DT cord-009571-mygj2nd4 571 14 secretion secretion NN cord-009571-mygj2nd4 571 15 of of IN cord-009571-mygj2nd4 571 16 collagenase collagenase NNP cord-009571-mygj2nd4 571 17 from from IN cord-009571-mygj2nd4 571 18 synovial synovial JJ cord-009571-mygj2nd4 571 19 cells cell NNS cord-009571-mygj2nd4 571 20 leading lead VBG cord-009571-mygj2nd4 571 21 to to IN cord-009571-mygj2nd4 571 22 further further JJ cord-009571-mygj2nd4 571 23 cartilage cartilage NN cord-009571-mygj2nd4 571 24 destruction destruction NN cord-009571-mygj2nd4 571 25 . . . cord-009571-mygj2nd4 572 1 Although although IN cord-009571-mygj2nd4 572 2 intraarticular intraarticular JJ cord-009571-mygj2nd4 572 3 corticosteroid corticosteroid NN cord-009571-mygj2nd4 572 4 injection injection NN cord-009571-mygj2nd4 572 5 has have VBZ cord-009571-mygj2nd4 572 6 been be VBN cord-009571-mygj2nd4 572 7 considered consider VBN cord-009571-mygj2nd4 572 8 a a DT cord-009571-mygj2nd4 572 9 therapeutic therapeutic JJ cord-009571-mygj2nd4 572 10 adjunct adjunct NN cord-009571-mygj2nd4 572 11 in in IN cord-009571-mygj2nd4 572 12 rheumatology rheumatology NN cord-009571-mygj2nd4 572 13 for for IN cord-009571-mygj2nd4 572 14 the the DT cord-009571-mygj2nd4 572 15 last last JJ cord-009571-mygj2nd4 572 16 25 25 CD cord-009571-mygj2nd4 572 17 years year NNS cord-009571-mygj2nd4 572 18 , , , cord-009571-mygj2nd4 572 19 scientific scientific JJ cord-009571-mygj2nd4 572 20 proof proof NN cord-009571-mygj2nd4 572 21 of of IN cord-009571-mygj2nd4 572 22 efficacy efficacy NN cord-009571-mygj2nd4 572 23 is be VBZ cord-009571-mygj2nd4 572 24 still still RB cord-009571-mygj2nd4 572 25 lacking lack VBG cord-009571-mygj2nd4 572 26 . . . cord-009571-mygj2nd4 573 1 The the DT cord-009571-mygj2nd4 573 2 present present JJ cord-009571-mygj2nd4 573 3 study study NN cord-009571-mygj2nd4 573 4 was be VBD cord-009571-mygj2nd4 573 5 undertaken undertake VBN cord-009571-mygj2nd4 573 6 , , , cord-009571-mygj2nd4 573 7 therefore therefore RB cord-009571-mygj2nd4 573 8 , , , cord-009571-mygj2nd4 573 9 to to TO cord-009571-mygj2nd4 573 10 determine determine VB cord-009571-mygj2nd4 573 11 the the DT cord-009571-mygj2nd4 573 12 effect effect NN cord-009571-mygj2nd4 573 13 of of IN cord-009571-mygj2nd4 573 14 intraarticular intraarticular JJ cord-009571-mygj2nd4 573 15 steroids steroid NNS cord-009571-mygj2nd4 573 16 on on IN cord-009571-mygj2nd4 573 17 pain pain NN cord-009571-mygj2nd4 573 18 in in IN cord-009571-mygj2nd4 573 19 the the DT cord-009571-mygj2nd4 573 20 osteoarthritic osteoarthritic JJ cord-009571-mygj2nd4 573 21 knee knee NN cord-009571-mygj2nd4 573 22 by by IN cord-009571-mygj2nd4 573 23 use use NN cord-009571-mygj2nd4 573 24 of of IN cord-009571-mygj2nd4 573 25 a a DT cord-009571-mygj2nd4 573 26 controlled control VBN cord-009571-mygj2nd4 573 27 , , , cord-009571-mygj2nd4 573 28 double double JJ cord-009571-mygj2nd4 573 29 - - HYPH cord-009571-mygj2nd4 573 30 blind blind JJ cord-009571-mygj2nd4 573 31 protocol protocol NN cord-009571-mygj2nd4 573 32 . . . cord-009571-mygj2nd4 574 1 Thirty thirty CD cord-009571-mygj2nd4 574 2 - - HYPH cord-009571-mygj2nd4 574 3 four four CD cord-009571-mygj2nd4 574 4 patients patient NNS cord-009571-mygj2nd4 574 5 with with IN cord-009571-mygj2nd4 574 6 symptomatic symptomatic JJ cord-009571-mygj2nd4 574 7 osteoarthritis osteoarthritis NN cord-009571-mygj2nd4 574 8 of of IN cord-009571-mygj2nd4 574 9 the the DT cord-009571-mygj2nd4 574 10 knee knee NN cord-009571-mygj2nd4 574 11 were be VBD cord-009571-mygj2nd4 574 12 included include VBN cord-009571-mygj2nd4 574 13 in in IN cord-009571-mygj2nd4 574 14 the the DT cord-009571-mygj2nd4 574 15 study study NN cord-009571-mygj2nd4 574 16 . . . cord-009571-mygj2nd4 575 1 Patients patient NNS cord-009571-mygj2nd4 575 2 previously previously RB cord-009571-mygj2nd4 575 3 injected inject VBN cord-009571-mygj2nd4 575 4 with with IN cord-009571-mygj2nd4 575 5 local local JJ cord-009571-mygj2nd4 575 6 steroids steroid NNS cord-009571-mygj2nd4 575 7 were be VBD cord-009571-mygj2nd4 575 8 excluded exclude VBN cord-009571-mygj2nd4 575 9 . . . cord-009571-mygj2nd4 576 1 Half half PDT cord-009571-mygj2nd4 576 2 the the DT cord-009571-mygj2nd4 576 3 patients patient NNS cord-009571-mygj2nd4 576 4 were be VBD cord-009571-mygj2nd4 576 5 treated treat VBN cord-009571-mygj2nd4 576 6 with with IN cord-009571-mygj2nd4 576 7 20 20 CD cord-009571-mygj2nd4 576 8 mg mg NN cord-009571-mygj2nd4 576 9 of of IN cord-009571-mygj2nd4 576 10 triamcinolone triamcinolone NNP cord-009571-mygj2nd4 576 11 hexacetonide hexacetonide NNP cord-009571-mygj2nd4 576 12 injected inject VBD cord-009571-mygj2nd4 576 13 into into IN cord-009571-mygj2nd4 576 14 the the DT cord-009571-mygj2nd4 576 15 knee knee NN cord-009571-mygj2nd4 576 16 , , , cord-009571-mygj2nd4 576 17 the the DT cord-009571-mygj2nd4 576 18 other other JJ cord-009571-mygj2nd4 576 19 half half NN cord-009571-mygj2nd4 576 20 with with IN cord-009571-mygj2nd4 576 21 the the DT cord-009571-mygj2nd4 576 22 same same JJ cord-009571-mygj2nd4 576 23 volume volume NN cord-009571-mygj2nd4 576 24 of of IN cord-009571-mygj2nd4 576 25 placebo placebo NN cord-009571-mygj2nd4 576 26 ( ( -LRB- cord-009571-mygj2nd4 576 27 vehicle vehicle NN cord-009571-mygj2nd4 576 28 without without IN cord-009571-mygj2nd4 576 29 steroid steroid NN cord-009571-mygj2nd4 576 30 ) ) -RRB- cord-009571-mygj2nd4 576 31 . . . cord-009571-mygj2nd4 577 1 The the DT cord-009571-mygj2nd4 577 2 two two CD cord-009571-mygj2nd4 577 3 physician physician NN cord-009571-mygj2nd4 577 4 - - HYPH cord-009571-mygj2nd4 577 5 experimenters experimenter NNS cord-009571-mygj2nd4 577 6 performed perform VBD cord-009571-mygj2nd4 577 7 the the DT cord-009571-mygj2nd4 577 8 arthrocentesis arthrocentesis NN cord-009571-mygj2nd4 577 9 and and CC cord-009571-mygj2nd4 577 10 withdrew withdraw VBD cord-009571-mygj2nd4 577 11 any any DT cord-009571-mygj2nd4 577 12 synovial synovial JJ cord-009571-mygj2nd4 577 13 fluid fluid NN cord-009571-mygj2nd4 577 14 , , , cord-009571-mygj2nd4 577 15 if if IN cord-009571-mygj2nd4 577 16 possible possible JJ cord-009571-mygj2nd4 577 17 . . . cord-009571-mygj2nd4 578 1 A a DT cord-009571-mygj2nd4 578 2 nurse nurse NN cord-009571-mygj2nd4 578 3 - - HYPH cord-009571-mygj2nd4 578 4 assistant assistant NN cord-009571-mygj2nd4 578 5 then then RB cord-009571-mygj2nd4 578 6 injected inject VBN cord-009571-mygj2nd4 578 7 either either CC cord-009571-mygj2nd4 578 8 steroid steroid NN cord-009571-mygj2nd4 578 9 or or CC cord-009571-mygj2nd4 578 10 placebo placebo NN cord-009571-mygj2nd4 578 11 through through IN cord-009571-mygj2nd4 578 12 the the DT cord-009571-mygj2nd4 578 13 same same JJ cord-009571-mygj2nd4 578 14 needle needle NN cord-009571-mygj2nd4 578 15 according accord VBG cord-009571-mygj2nd4 578 16 to to IN cord-009571-mygj2nd4 578 17 a a DT cord-009571-mygj2nd4 578 18 predetermined predetermine VBN cord-009571-mygj2nd4 578 19 , , , cord-009571-mygj2nd4 578 20 random random JJ cord-009571-mygj2nd4 578 21 schedule schedule NN cord-009571-mygj2nd4 578 22 . . . cord-009571-mygj2nd4 579 1 Thus thus RB cord-009571-mygj2nd4 579 2 , , , cord-009571-mygj2nd4 579 3 the the DT cord-009571-mygj2nd4 579 4 physicians physician NNS cord-009571-mygj2nd4 579 5 who who WP cord-009571-mygj2nd4 579 6 conducted conduct VBD cord-009571-mygj2nd4 579 7 the the DT cord-009571-mygj2nd4 579 8 study study NN cord-009571-mygj2nd4 579 9 did do VBD cord-009571-mygj2nd4 579 10 not not RB cord-009571-mygj2nd4 579 11 know know VB cord-009571-mygj2nd4 579 12 the the DT cord-009571-mygj2nd4 579 13 nature nature NN cord-009571-mygj2nd4 579 14 of of IN cord-009571-mygj2nd4 579 15 the the DT cord-009571-mygj2nd4 579 16 material material NN cord-009571-mygj2nd4 579 17 each each DT cord-009571-mygj2nd4 579 18 patient patient NN cord-009571-mygj2nd4 579 19 received receive VBD cord-009571-mygj2nd4 579 20 . . . cord-009571-mygj2nd4 580 1 Knee knee NN cord-009571-mygj2nd4 580 2 pain pain NN cord-009571-mygj2nd4 580 3 was be VBD cord-009571-mygj2nd4 580 4 quantified quantify VBN cord-009571-mygj2nd4 580 5 prior prior RB cord-009571-mygj2nd4 580 6 to to IN cord-009571-mygj2nd4 580 7 , , , cord-009571-mygj2nd4 580 8 and and CC cord-009571-mygj2nd4 580 9 at at IN cord-009571-mygj2nd4 580 10 1 1 CD cord-009571-mygj2nd4 580 11 , , , cord-009571-mygj2nd4 580 12 4 4 CD cord-009571-mygj2nd4 580 13 , , , cord-009571-mygj2nd4 580 14 6 6 CD cord-009571-mygj2nd4 580 15 , , , cord-009571-mygj2nd4 580 16 and and CC cord-009571-mygj2nd4 580 17 8 8 CD cord-009571-mygj2nd4 580 18 weeks week NNS cord-009571-mygj2nd4 580 19 after after IN cord-009571-mygj2nd4 580 20 injection injection NN cord-009571-mygj2nd4 580 21 . . . cord-009571-mygj2nd4 581 1 At at IN cord-009571-mygj2nd4 581 2 1 1 CD cord-009571-mygj2nd4 581 3 week week NN cord-009571-mygj2nd4 581 4 the the DT cord-009571-mygj2nd4 581 5 steroid steroid NN cord-009571-mygj2nd4 581 6 group group NN cord-009571-mygj2nd4 581 7 had have VBD cord-009571-mygj2nd4 581 8 significantly significantly RB cord-009571-mygj2nd4 581 9 reduced reduce VBN cord-009571-mygj2nd4 581 10 knee knee NN cord-009571-mygj2nd4 581 11 pain pain NN cord-009571-mygj2nd4 581 12 compared compare VBN cord-009571-mygj2nd4 581 13 with with IN cord-009571-mygj2nd4 581 14 the the DT cord-009571-mygj2nd4 581 15 pretreatment pretreatment NN cord-009571-mygj2nd4 581 16 assessment assessment NN cord-009571-mygj2nd4 581 17 . . . cord-009571-mygj2nd4 582 1 This this DT cord-009571-mygj2nd4 582 2 reduction reduction NN cord-009571-mygj2nd4 582 3 persisted persist VBD cord-009571-mygj2nd4 582 4 through through IN cord-009571-mygj2nd4 582 5 the the DT cord-009571-mygj2nd4 582 6 8 8 CD cord-009571-mygj2nd4 582 7 week week NN cord-009571-mygj2nd4 582 8 evaluation evaluation NN cord-009571-mygj2nd4 582 9 period period NN cord-009571-mygj2nd4 582 10 . . . cord-009571-mygj2nd4 583 1 The the DT cord-009571-mygj2nd4 583 2 placebo placebo NN cord-009571-mygj2nd4 583 3 group group NN cord-009571-mygj2nd4 583 4 also also RB cord-009571-mygj2nd4 583 5 exhibited exhibit VBD cord-009571-mygj2nd4 583 6 a a DT cord-009571-mygj2nd4 583 7 significant significant JJ cord-009571-mygj2nd4 583 8 amount amount NN cord-009571-mygj2nd4 583 9 of of IN cord-009571-mygj2nd4 583 10 pain pain NN cord-009571-mygj2nd4 583 11 relief relief NN cord-009571-mygj2nd4 583 12 at at IN cord-009571-mygj2nd4 583 13 1 1 CD cord-009571-mygj2nd4 583 14 week week NN cord-009571-mygj2nd4 583 15 , , , cord-009571-mygj2nd4 583 16 but but CC cord-009571-mygj2nd4 583 17 this this DT cord-009571-mygj2nd4 583 18 was be VBD cord-009571-mygj2nd4 583 19 significantly significantly RB cord-009571-mygj2nd4 583 20 less less JJR cord-009571-mygj2nd4 583 21 than than IN cord-009571-mygj2nd4 583 22 that that DT cord-009571-mygj2nd4 583 23 experienced experience VBN cord-009571-mygj2nd4 583 24 by by IN cord-009571-mygj2nd4 583 25 the the DT cord-009571-mygj2nd4 583 26 steroid steroid NN cord-009571-mygj2nd4 583 27 group group NN cord-009571-mygj2nd4 583 28 . . . cord-009571-mygj2nd4 584 1 From from IN cord-009571-mygj2nd4 584 2 4 4 CD cord-009571-mygj2nd4 584 3 through through IN cord-009571-mygj2nd4 584 4 8 8 CD cord-009571-mygj2nd4 584 5 weeks week NNS cord-009571-mygj2nd4 584 6 there there EX cord-009571-mygj2nd4 584 7 was be VBD cord-009571-mygj2nd4 584 8 no no DT cord-009571-mygj2nd4 584 9 statistically statistically RB cord-009571-mygj2nd4 584 10 significant significant JJ cord-009571-mygj2nd4 584 11 difference difference NN cord-009571-mygj2nd4 584 12 between between IN cord-009571-mygj2nd4 584 13 the the DT cord-009571-mygj2nd4 584 14 2 2 CD cord-009571-mygj2nd4 584 15 groups group NNS cord-009571-mygj2nd4 584 16 . . . cord-009571-mygj2nd4 585 1 Whether whether IN cord-009571-mygj2nd4 585 2 or or CC cord-009571-mygj2nd4 585 3 not not RB cord-009571-mygj2nd4 585 4 synovial synovial JJ cord-009571-mygj2nd4 585 5 fluid fluid NN cord-009571-mygj2nd4 585 6 was be VBD cord-009571-mygj2nd4 585 7 initially initially RB cord-009571-mygj2nd4 585 8 aspirated aspirate VBN cord-009571-mygj2nd4 585 9 did do VBD cord-009571-mygj2nd4 585 10 not not RB cord-009571-mygj2nd4 585 11 affect affect VB cord-009571-mygj2nd4 585 12 results result NNS cord-009571-mygj2nd4 585 13 . . . cord-009571-mygj2nd4 586 1 Postinjection postinjection NN cord-009571-mygj2nd4 586 2 flares flare NNS cord-009571-mygj2nd4 586 3 occurred occur VBD cord-009571-mygj2nd4 586 4 as as RB cord-009571-mygj2nd4 586 5 often often RB cord-009571-mygj2nd4 586 6 with with IN cord-009571-mygj2nd4 586 7 placebo placebo NN cord-009571-mygj2nd4 586 8 as as IN cord-009571-mygj2nd4 586 9 with with IN cord-009571-mygj2nd4 586 10 steroids steroid NNS cord-009571-mygj2nd4 586 11 and and CC cord-009571-mygj2nd4 586 12 did do VBD cord-009571-mygj2nd4 586 13 not not RB cord-009571-mygj2nd4 586 14 affect affect VB cord-009571-mygj2nd4 586 15 the the DT cord-009571-mygj2nd4 586 16 subsequent subsequent JJ cord-009571-mygj2nd4 586 17 course course NN cord-009571-mygj2nd4 586 18 . . . cord-009571-mygj2nd4 587 1 It -PRON- PRP cord-009571-mygj2nd4 587 2 is be VBZ cord-009571-mygj2nd4 587 3 concluded conclude VBN cord-009571-mygj2nd4 587 4 that that IN cord-009571-mygj2nd4 587 5 intraarticular intraarticular NNP cord-009571-mygj2nd4 587 6 steroids steroid NNS cord-009571-mygj2nd4 587 7 reduce reduce VBP cord-009571-mygj2nd4 587 8 the the DT cord-009571-mygj2nd4 587 9 pain pain NN cord-009571-mygj2nd4 587 10 of of IN cord-009571-mygj2nd4 587 11 osteoarthritis osteoarthritis NN cord-009571-mygj2nd4 587 12 , , , cord-009571-mygj2nd4 587 13 but but CC cord-009571-mygj2nd4 587 14 such such PDT cord-009571-mygj2nd4 587 15 a a DT cord-009571-mygj2nd4 587 16 response response NN cord-009571-mygj2nd4 587 17 can can MD cord-009571-mygj2nd4 587 18 not not RB cord-009571-mygj2nd4 587 19 be be VB cord-009571-mygj2nd4 587 20 distinguished distinguish VBN cord-009571-mygj2nd4 587 21 from from IN cord-009571-mygj2nd4 587 22 a a DT cord-009571-mygj2nd4 587 23 placebo placebo NN cord-009571-mygj2nd4 587 24 effect effect NN cord-009571-mygj2nd4 587 25 by by IN cord-009571-mygj2nd4 587 26 4 4 CD cord-009571-mygj2nd4 587 27 weeks week NNS cord-009571-mygj2nd4 587 28 postinjection postinjection NN cord-009571-mygj2nd4 587 29 . . . cord-009571-mygj2nd4 588 1 It -PRON- PRP cord-009571-mygj2nd4 588 2 has have VBZ cord-009571-mygj2nd4 588 3 been be VBN cord-009571-mygj2nd4 588 4 reported report VBN cord-009571-mygj2nd4 588 5 previously previously RB cord-009571-mygj2nd4 588 6 that that IN cord-009571-mygj2nd4 588 7 antibodies antibody NNS cord-009571-mygj2nd4 588 8 to to IN cord-009571-mygj2nd4 588 9 histones histone NNS cord-009571-mygj2nd4 588 10 can can MD cord-009571-mygj2nd4 588 11 be be VB cord-009571-mygj2nd4 588 12 demonstrated demonstrate VBN cord-009571-mygj2nd4 588 13 by by IN cord-009571-mygj2nd4 588 14 immunofluorescence immunofluorescence NN cord-009571-mygj2nd4 588 15 . . . cord-009571-mygj2nd4 589 1 When when WRB cord-009571-mygj2nd4 589 2 tissue tissue NN cord-009571-mygj2nd4 589 3 sections section NNS cord-009571-mygj2nd4 589 4 are be VBP cord-009571-mygj2nd4 589 5 extracted extract VBN cord-009571-mygj2nd4 589 6 with with IN cord-009571-mygj2nd4 589 7 0.1 0.1 CD cord-009571-mygj2nd4 589 8 N n CD cord-009571-mygj2nd4 589 9 HCI HCI NNP cord-009571-mygj2nd4 589 10 , , , cord-009571-mygj2nd4 589 11 histones histone NNS cord-009571-mygj2nd4 589 12 are be VBP cord-009571-mygj2nd4 589 13 eluted elute VBN cord-009571-mygj2nd4 589 14 from from IN cord-009571-mygj2nd4 589 15 nuclei nucleus NNS cord-009571-mygj2nd4 589 16 , , , cord-009571-mygj2nd4 589 17 and and CC cord-009571-mygj2nd4 589 18 the the DT cord-009571-mygj2nd4 589 19 extracted extract VBN cord-009571-mygj2nd4 589 20 tissue tissue NN cord-009571-mygj2nd4 589 21 contains contain VBZ cord-009571-mygj2nd4 589 22 only only RB cord-009571-mygj2nd4 589 23 D d NN cord-009571-mygj2nd4 589 24 N n NN cord-009571-mygj2nd4 589 25 A a DT cord-009571-mygj2nd4 589 26 devoid devoid NN cord-009571-mygj2nd4 589 27 of of IN cord-009571-mygj2nd4 589 28 nuclear nuclear JJ cord-009571-mygj2nd4 589 29 proteins protein NNS cord-009571-mygj2nd4 589 30 . . . cord-009571-mygj2nd4 590 1 Histones histone NNS cord-009571-mygj2nd4 590 2 can can MD cord-009571-mygj2nd4 590 3 be be VB cord-009571-mygj2nd4 590 4 reconstituted reconstitute VBN cord-009571-mygj2nd4 590 5 to to IN cord-009571-mygj2nd4 590 6 nuclear nuclear JJ cord-009571-mygj2nd4 590 7 D D NNP cord-009571-mygj2nd4 590 8 N N NNP cord-009571-mygj2nd4 590 9 A a NN cord-009571-mygj2nd4 590 10 by by IN cord-009571-mygj2nd4 590 11 incubation incubation NN cord-009571-mygj2nd4 590 12 of of IN cord-009571-mygj2nd4 590 13 acid acid NN cord-009571-mygj2nd4 590 14 - - HYPH cord-009571-mygj2nd4 590 15 extracted extract VBN cord-009571-mygj2nd4 590 16 tissues tissue NNS cord-009571-mygj2nd4 590 17 with with IN cord-009571-mygj2nd4 590 18 purified purify VBN cord-009571-mygj2nd4 590 19 calf calf NN cord-009571-mygj2nd4 590 20 thymus thymus NN cord-009571-mygj2nd4 590 21 histones histone NNS cord-009571-mygj2nd4 590 22 . . . cord-009571-mygj2nd4 591 1 Sera Sera NNP cord-009571-mygj2nd4 591 2 containing contain VBG cord-009571-mygj2nd4 591 3 antibodies antibody NNS cord-009571-mygj2nd4 591 4 to to IN cord-009571-mygj2nd4 591 5 histones histone NNS cord-009571-mygj2nd4 591 6 show show VBP cord-009571-mygj2nd4 591 7 positive positive JJ cord-009571-mygj2nd4 591 8 antinuclear antinuclear JJ cord-009571-mygj2nd4 591 9 antibody antibody NN cord-009571-mygj2nd4 591 10 ( ( -LRB- cord-009571-mygj2nd4 591 11 ANA ANA NNP cord-009571-mygj2nd4 591 12 ) ) -RRB- cord-009571-mygj2nd4 591 13 staining stain VBG cord-009571-mygj2nd4 591 14 on on IN cord-009571-mygj2nd4 591 15 untreated untreated JJ cord-009571-mygj2nd4 591 16 tissue tissue NN cord-009571-mygj2nd4 591 17 , , , cord-009571-mygj2nd4 591 18 become become VB cord-009571-mygj2nd4 591 19 ANA ANA NNP cord-009571-mygj2nd4 591 20 negative negative JJ cord-009571-mygj2nd4 591 21 on on IN cord-009571-mygj2nd4 591 22 acid acid NN cord-009571-mygj2nd4 591 23 - - HYPH cord-009571-mygj2nd4 591 24 extracted extract VBN cord-009571-mygj2nd4 591 25 tissue tissue NN cord-009571-mygj2nd4 591 26 and and CC cord-009571-mygj2nd4 591 27 regain regain VB cord-009571-mygj2nd4 591 28 ANA ANA NNP cord-009571-mygj2nd4 591 29 positivity positivity NN cord-009571-mygj2nd4 591 30 on on IN cord-009571-mygj2nd4 591 31 histone histone NN cord-009571-mygj2nd4 591 32 - - HYPH cord-009571-mygj2nd4 591 33 reconstituted reconstitute VBN cord-009571-mygj2nd4 591 34 tissue tissue NN cord-009571-mygj2nd4 591 35 . . . cord-009571-mygj2nd4 592 1 Sera Sera NNP cord-009571-mygj2nd4 592 2 from from IN cord-009571-mygj2nd4 592 3 23 23 CD cord-009571-mygj2nd4 592 4 patients patient NNS cord-009571-mygj2nd4 592 5 with with IN cord-009571-mygj2nd4 592 6 drug drug NN cord-009571-mygj2nd4 592 7 - - HYPH cord-009571-mygj2nd4 592 8 induced induce VBN cord-009571-mygj2nd4 592 9 lupus lupus NN cord-009571-mygj2nd4 592 10 erythematosus erythematosus NN cord-009571-mygj2nd4 592 11 ( ( -LRB- cord-009571-mygj2nd4 592 12 procainamide procainamide NNP cord-009571-mygj2nd4 592 13 19 19 CD cord-009571-mygj2nd4 592 14 , , , cord-009571-mygj2nd4 592 15 isoniazid isoniazid NNP cord-009571-mygj2nd4 592 16 2 2 CD cord-009571-mygj2nd4 592 17 , , , cord-009571-mygj2nd4 592 18 nitrofurantoin nitrofurantoin NNP cord-009571-mygj2nd4 592 19 2 2 CD cord-009571-mygj2nd4 592 20 ) ) -RRB- cord-009571-mygj2nd4 592 21 and and CC cord-009571-mygj2nd4 592 22 20 20 CD cord-009571-mygj2nd4 592 23 patients patient NNS cord-009571-mygj2nd4 592 24 with with IN cord-009571-mygj2nd4 592 25 idiopathic idiopathic JJ cord-009571-mygj2nd4 592 26 ( ( -LRB- cord-009571-mygj2nd4 592 27 not not RB cord-009571-mygj2nd4 592 28 drug drug NN cord-009571-mygj2nd4 592 29 - - HYPH cord-009571-mygj2nd4 592 30 induced induce VBN cord-009571-mygj2nd4 592 31 ) ) -RRB- cord-009571-mygj2nd4 592 32 systemic systemic JJ cord-009571-mygj2nd4 592 33 lupus lupus NN cord-009571-mygj2nd4 592 34 erythematosus erythematosus NN cord-009571-mygj2nd4 592 35 ( ( -LRB- cord-009571-mygj2nd4 592 36 SLE SLE NNP cord-009571-mygj2nd4 592 37 ) ) -RRB- cord-009571-mygj2nd4 592 38 were be VBD cord-009571-mygj2nd4 592 39 studied study VBN cord-009571-mygj2nd4 592 40 . . . cord-009571-mygj2nd4 593 1 All all DT cord-009571-mygj2nd4 593 2 23 23 CD cord-009571-mygj2nd4 593 3 drug drug NN cord-009571-mygj2nd4 593 4 - - HYPH cord-009571-mygj2nd4 593 5 LE LE NNP cord-009571-mygj2nd4 593 6 patients patient NNS cord-009571-mygj2nd4 593 7 had have VBD cord-009571-mygj2nd4 593 8 positive positive JJ cord-009571-mygj2nd4 593 9 ANA ANA NNP cord-009571-mygj2nd4 593 10 on on IN cord-009571-mygj2nd4 593 11 control control NN cord-009571-mygj2nd4 593 12 tissues tissue NNS cord-009571-mygj2nd4 593 13 but but CC cord-009571-mygj2nd4 593 14 ANA ANA NNP cord-009571-mygj2nd4 593 15 became become VBD cord-009571-mygj2nd4 593 16 completely completely RB cord-009571-mygj2nd4 593 17 negative negative JJ cord-009571-mygj2nd4 593 18 on on IN cord-009571-mygj2nd4 593 19 acid acid NN cord-009571-mygj2nd4 593 20 - - HYPH cord-009571-mygj2nd4 593 21 extracted extract VBN cord-009571-mygj2nd4 593 22 tissues tissue NNS cord-009571-mygj2nd4 593 23 . . . cord-009571-mygj2nd4 594 1 On on IN cord-009571-mygj2nd4 594 2 histone histone NN cord-009571-mygj2nd4 594 3 - - HYPH cord-009571-mygj2nd4 594 4 reconstituted reconstitute VBN cord-009571-mygj2nd4 594 5 tissues tissue NNS cord-009571-mygj2nd4 594 6 , , , cord-009571-mygj2nd4 594 7 22/23 22/23 CD cord-009571-mygj2nd4 594 8 again again RB cord-009571-mygj2nd4 594 9 became become VBD cord-009571-mygj2nd4 594 10 ANA ANA NNP cord-009571-mygj2nd4 594 11 positive positive JJ cord-009571-mygj2nd4 594 12 . . . cord-009571-mygj2nd4 595 1 In in IN cord-009571-mygj2nd4 595 2 contrast contrast NN cord-009571-mygj2nd4 595 3 , , , cord-009571-mygj2nd4 595 4 of of IN cord-009571-mygj2nd4 595 5 20 20 CD cord-009571-mygj2nd4 595 6 idiopathic idiopathic JJ cord-009571-mygj2nd4 595 7 SLE SLE NNP cord-009571-mygj2nd4 595 8 sera sera NNP cord-009571-mygj2nd4 595 9 which which WDT cord-009571-mygj2nd4 595 10 were be VBD cord-009571-mygj2nd4 595 11 positive positive JJ cord-009571-mygj2nd4 595 12 for for IN cord-009571-mygj2nd4 595 13 ANA ANA NNP cord-009571-mygj2nd4 595 14 on on IN cord-009571-mygj2nd4 595 15 control control NN cord-009571-mygj2nd4 595 16 tissues tissue NNS cord-009571-mygj2nd4 595 17 , , , cord-009571-mygj2nd4 595 18 only only RB cord-009571-mygj2nd4 595 19 12 12 CD cord-009571-mygj2nd4 595 20 became become VBD cord-009571-mygj2nd4 595 21 negative negative JJ cord-009571-mygj2nd4 595 22 and and CC cord-009571-mygj2nd4 595 23 of of IN cord-009571-mygj2nd4 595 24 these these DT cord-009571-mygj2nd4 595 25 , , , cord-009571-mygj2nd4 595 26 4 4 CD cord-009571-mygj2nd4 595 27 again again RB cord-009571-mygj2nd4 595 28 became become VBD cord-009571-mygj2nd4 595 29 ANA ANA NNP cord-009571-mygj2nd4 595 30 positive positive JJ cord-009571-mygj2nd4 595 31 on on IN cord-009571-mygj2nd4 595 32 histone histone NN cord-009571-mygj2nd4 595 33 - - HYPH cord-009571-mygj2nd4 595 34 reconstituted reconstitute VBN cord-009571-mygj2nd4 595 35 tissues tissue NNS cord-009571-mygj2nd4 595 36 while while IN cord-009571-mygj2nd4 595 37 the the DT cord-009571-mygj2nd4 595 38 other other JJ cord-009571-mygj2nd4 595 39 8 8 CD cord-009571-mygj2nd4 595 40 remained remain VBD cord-009571-mygj2nd4 595 41 negative negative JJ cord-009571-mygj2nd4 595 42 . . . cord-009571-mygj2nd4 596 1 Three three CD cord-009571-mygj2nd4 596 2 other other JJ cord-009571-mygj2nd4 596 3 SLE SLE NNP cord-009571-mygj2nd4 596 4 sera sera NNP cord-009571-mygj2nd4 596 5 showed show VBD cord-009571-mygj2nd4 596 6 partial partial JJ cord-009571-mygj2nd4 596 7 reduction reduction NN cord-009571-mygj2nd4 596 8 in in IN cord-009571-mygj2nd4 596 9 ANA ANA NNP cord-009571-mygj2nd4 596 10 titer titer NN cord-009571-mygj2nd4 596 11 but but CC cord-009571-mygj2nd4 596 12 increased increase VBD cord-009571-mygj2nd4 596 13 in in IN cord-009571-mygj2nd4 596 14 titer titer NN cord-009571-mygj2nd4 596 15 on on IN cord-009571-mygj2nd4 596 16 histone histone NN cord-009571-mygj2nd4 596 17 - - HYPH cord-009571-mygj2nd4 596 18 reconstituted reconstitute VBN cord-009571-mygj2nd4 596 19 tissue tissue NN cord-009571-mygj2nd4 596 20 . . . cord-009571-mygj2nd4 597 1 Thus thus RB cord-009571-mygj2nd4 597 2 , , , cord-009571-mygj2nd4 597 3 22/23 22/23 CD cord-009571-mygj2nd4 597 4 drug drug NN cord-009571-mygj2nd4 597 5 - - HYPH cord-009571-mygj2nd4 597 6 LE LE NNP cord-009571-mygj2nd4 597 7 patients patient NNS cord-009571-mygj2nd4 597 8 ( ( -LRB- cord-009571-mygj2nd4 597 9 96 96 CD cord-009571-mygj2nd4 597 10 % % NN cord-009571-mygj2nd4 597 11 ) ) -RRB- cord-009571-mygj2nd4 597 12 had have VBD cord-009571-mygj2nd4 597 13 antibodies antibody NNS cord-009571-mygj2nd4 597 14 to to IN cord-009571-mygj2nd4 597 15 histones histone NNS cord-009571-mygj2nd4 597 16 compared compare VBN cord-009571-mygj2nd4 597 17 to to IN cord-009571-mygj2nd4 597 18 7/20 7/20 CD cord-009571-mygj2nd4 597 19 SLE SLE NNP cord-009571-mygj2nd4 597 20 patients patient NNS cord-009571-mygj2nd4 597 21 ( ( -LRB- cord-009571-mygj2nd4 597 22 35 35 CD cord-009571-mygj2nd4 597 23 % % NN cord-009571-mygj2nd4 597 24 ) ) -RRB- cord-009571-mygj2nd4 597 25 . . . cord-009571-mygj2nd4 598 1 To to TO cord-009571-mygj2nd4 598 2 determine determine VB cord-009571-mygj2nd4 598 3 the the DT cord-009571-mygj2nd4 598 4 specificity specificity NN cord-009571-mygj2nd4 598 5 of of IN cord-009571-mygj2nd4 598 6 anti anti JJ cord-009571-mygj2nd4 598 7 - - JJ cord-009571-mygj2nd4 598 8 histone histone JJ cord-009571-mygj2nd4 598 9 antibodies antibody NNS cord-009571-mygj2nd4 598 10 , , , cord-009571-mygj2nd4 598 11 the the DT cord-009571-mygj2nd4 598 12 H1 H1 NNP cord-009571-mygj2nd4 598 13 , , , cord-009571-mygj2nd4 598 14 H2A H2A NNP cord-009571-mygj2nd4 598 15 - - HYPH cord-009571-mygj2nd4 598 16 H2B H2B NNP cord-009571-mygj2nd4 598 17 and and CC cord-009571-mygj2nd4 598 18 H3-H4 H3-H4 NNP cord-009571-mygj2nd4 598 19 fractions fraction NNS cord-009571-mygj2nd4 598 20 of of IN cord-009571-mygj2nd4 598 21 calf calf NN cord-009571-mygj2nd4 598 22 thymus thymus NN cord-009571-mygj2nd4 598 23 histone histone NN cord-009571-mygj2nd4 598 24 were be VBD cord-009571-mygj2nd4 598 25 prepared prepare VBN cord-009571-mygj2nd4 598 26 by by IN cord-009571-mygj2nd4 598 27 differential differential JJ cord-009571-mygj2nd4 598 28 salt salt NN cord-009571-mygj2nd4 598 29 extraction extraction NN cord-009571-mygj2nd4 598 30 and and CC cord-009571-mygj2nd4 598 31 Sephadex Sephadex NNP cord-009571-mygj2nd4 598 32 gel gel NN cord-009571-mygj2nd4 598 33 filtration filtration NN cord-009571-mygj2nd4 598 34 and and CC cord-009571-mygj2nd4 598 35 used use VBN cord-009571-mygj2nd4 598 36 in in IN cord-009571-mygj2nd4 598 37 reconstitution reconstitution NN cord-009571-mygj2nd4 598 38 experiments experiment NNS cord-009571-mygj2nd4 598 39 . . . cord-009571-mygj2nd4 599 1 It -PRON- PRP cord-009571-mygj2nd4 599 2 was be VBD cord-009571-mygj2nd4 599 3 shown show VBN cord-009571-mygj2nd4 599 4 that that IN cord-009571-mygj2nd4 599 5 in in IN cord-009571-mygj2nd4 599 6 21/22 21/22 CD cord-009571-mygj2nd4 599 7 of of IN cord-009571-mygj2nd4 599 8 the the DT cord-009571-mygj2nd4 599 9 drug drug NN cord-009571-mygj2nd4 599 10 - - HYPH cord-009571-mygj2nd4 599 11 induced induce VBN cord-009571-mygj2nd4 599 12 sera sera NNP cord-009571-mygj2nd4 599 13 antibodies antibody NNS cord-009571-mygj2nd4 599 14 were be VBD cord-009571-mygj2nd4 599 15 primarily primarily RB cord-009571-mygj2nd4 599 16 against against IN cord-009571-mygj2nd4 599 17 H2A h2a CD cord-009571-mygj2nd4 599 18 - - HYPH cord-009571-mygj2nd4 599 19 H28 H28 NNP cord-009571-mygj2nd4 599 20 , , , cord-009571-mygj2nd4 599 21 while while IN cord-009571-mygj2nd4 599 22 in in IN cord-009571-mygj2nd4 599 23 the the DT cord-009571-mygj2nd4 599 24 5 5 CD cord-009571-mygj2nd4 599 25 idiopathic idiopathic JJ cord-009571-mygj2nd4 599 26 SLE SLE NNP cord-009571-mygj2nd4 599 27 sera sera NNP cord-009571-mygj2nd4 599 28 studied study VBD cord-009571-mygj2nd4 599 29 , , , cord-009571-mygj2nd4 599 30 antibodies antibody NNS cord-009571-mygj2nd4 599 31 to to IN cord-009571-mygj2nd4 599 32 all all DT cord-009571-mygj2nd4 599 33 classes class NNS cord-009571-mygj2nd4 599 34 of of IN cord-009571-mygj2nd4 599 35 histone histone NN cord-009571-mygj2nd4 599 36 were be VBD cord-009571-mygj2nd4 599 37 found find VBN cord-009571-mygj2nd4 599 38 . . . cord-009571-mygj2nd4 600 1 A a DT cord-009571-mygj2nd4 600 2 further further JJ cord-009571-mygj2nd4 600 3 difference difference NN cord-009571-mygj2nd4 600 4 was be VBD cord-009571-mygj2nd4 600 5 that that IN cord-009571-mygj2nd4 600 6 idiopathic idiopathic JJ cord-009571-mygj2nd4 600 7 SLE SLE NNP cord-009571-mygj2nd4 600 8 sera sera NNP cord-009571-mygj2nd4 600 9 had have VBD cord-009571-mygj2nd4 600 10 antibodies antibody NNS cord-009571-mygj2nd4 600 11 to to IN cord-009571-mygj2nd4 600 12 native native JJ cord-009571-mygj2nd4 600 13 DNA dna NN cord-009571-mygj2nd4 600 14 and and CC cord-009571-mygj2nd4 600 15 to to IN cord-009571-mygj2nd4 600 16 the the DT cord-009571-mygj2nd4 600 17 nonhistone nonhistone NN cord-009571-mygj2nd4 600 18 proteins protein NNS cord-009571-mygj2nd4 600 19 Sm Sm NNP cord-009571-mygj2nd4 600 20 and and CC cord-009571-mygj2nd4 600 21 nuclear nuclear JJ cord-009571-mygj2nd4 600 22 RNP rnp NN cord-009571-mygj2nd4 600 23 whereas whereas IN cord-009571-mygj2nd4 600 24 drug drug NN cord-009571-mygj2nd4 600 25 - - HYPH cord-009571-mygj2nd4 600 26 induced induce VBN cord-009571-mygj2nd4 600 27 LE LE NNP cord-009571-mygj2nd4 600 28 sera sera NNP cord-009571-mygj2nd4 600 29 did do VBD cord-009571-mygj2nd4 600 30 not not RB cord-009571-mygj2nd4 600 31 . . . cord-009571-mygj2nd4 601 1 The the DT cord-009571-mygj2nd4 601 2 heterogeneity heterogeneity NN cord-009571-mygj2nd4 601 3 of of IN cord-009571-mygj2nd4 601 4 ANAs ana NNS cord-009571-mygj2nd4 601 5 in in IN cord-009571-mygj2nd4 601 6 idiopathic idiopathic JJ cord-009571-mygj2nd4 601 7 SLE SLE NNP cord-009571-mygj2nd4 601 8 and and CC cord-009571-mygj2nd4 601 9 the the DT cord-009571-mygj2nd4 601 10 striking striking JJ cord-009571-mygj2nd4 601 11 prevalence prevalence NN cord-009571-mygj2nd4 601 12 of of IN cord-009571-mygj2nd4 601 13 anti anti JJ cord-009571-mygj2nd4 601 14 - - JJ cord-009571-mygj2nd4 601 15 histone histone JJ cord-009571-mygj2nd4 601 16 antibodies antibody NNS cord-009571-mygj2nd4 601 17 in in IN cord-009571-mygj2nd4 601 18 drug drug NN cord-009571-mygj2nd4 601 19 - - HYPH cord-009571-mygj2nd4 601 20 induced induce VBN cord-009571-mygj2nd4 601 21 LE LE NNP cord-009571-mygj2nd4 601 22 , , , cord-009571-mygj2nd4 601 23 as as IN cord-009571-mygj2nd4 601 24 demonstrated demonstrate VBN cord-009571-mygj2nd4 601 25 by by IN cord-009571-mygj2nd4 601 26 immunofluorescence immunofluorescence NN cord-009571-mygj2nd4 601 27 , , , cord-009571-mygj2nd4 601 28 have have VBP cord-009571-mygj2nd4 601 29 been be VBN cord-009571-mygj2nd4 601 30 valuable valuable JJ cord-009571-mygj2nd4 601 31 clinically clinically RB cord-009571-mygj2nd4 601 32 in in IN cord-009571-mygj2nd4 601 33 differentiating differentiate VBG cord-009571-mygj2nd4 601 34 between between IN cord-009571-mygj2nd4 601 35 these these DT cord-009571-mygj2nd4 601 36 two two CD cord-009571-mygj2nd4 601 37 syndromes syndrome NNS cord-009571-mygj2nd4 601 38 . . . cord-009571-mygj2nd4 602 1 The the DT cord-009571-mygj2nd4 602 2 etiology etiology NN cord-009571-mygj2nd4 602 3 of of IN cord-009571-mygj2nd4 602 4 PSS PSS NNP cord-009571-mygj2nd4 602 5 is be VBZ cord-009571-mygj2nd4 602 6 unknown unknown JJ cord-009571-mygj2nd4 602 7 and and CC cord-009571-mygj2nd4 602 8 progress progress NN cord-009571-mygj2nd4 602 9 toward toward IN cord-009571-mygj2nd4 602 10 its -PRON- PRP$ cord-009571-mygj2nd4 602 11 understanding understanding NN cord-009571-mygj2nd4 602 12 has have VBZ cord-009571-mygj2nd4 602 13 been be VBN cord-009571-mygj2nd4 602 14 hampered hamper VBN cord-009571-mygj2nd4 602 15 by by IN cord-009571-mygj2nd4 602 16 the the DT cord-009571-mygj2nd4 602 17 lack lack NN cord-009571-mygj2nd4 602 18 of of IN cord-009571-mygj2nd4 602 19 a a DT cord-009571-mygj2nd4 602 20 model model NN cord-009571-mygj2nd4 602 21 for for IN cord-009571-mygj2nd4 602 22 the the DT cord-009571-mygj2nd4 602 23 disease disease NN cord-009571-mygj2nd4 602 24 . . . cord-009571-mygj2nd4 603 1 It -PRON- PRP cord-009571-mygj2nd4 603 2 has have VBZ cord-009571-mygj2nd4 603 3 recently recently RB cord-009571-mygj2nd4 603 4 been be VBN cord-009571-mygj2nd4 603 5 reported report VBN cord-009571-mygj2nd4 603 6 that that IN cord-009571-mygj2nd4 603 7 skin skin NN cord-009571-mygj2nd4 603 8 changes change NNS cord-009571-mygj2nd4 603 9 similar similar JJ cord-009571-mygj2nd4 603 10 to to IN cord-009571-mygj2nd4 603 11 those those DT cord-009571-mygj2nd4 603 12 of of IN cord-009571-mygj2nd4 603 13 scleroderma scleroderma NNS cord-009571-mygj2nd4 603 14 develop develop VBP cord-009571-mygj2nd4 603 15 in in IN cord-009571-mygj2nd4 603 16 some some DT cord-009571-mygj2nd4 603 17 long long JJ cord-009571-mygj2nd4 603 18 - - HYPH cord-009571-mygj2nd4 603 19 term term NN cord-009571-mygj2nd4 603 20 survivors survivor NNS cord-009571-mygj2nd4 603 21 of of IN cord-009571-mygj2nd4 603 22 bone bone NN cord-009571-mygj2nd4 603 23 marrow marrow NN cord-009571-mygj2nd4 603 24 transplantation transplantation NN cord-009571-mygj2nd4 603 25 ( ( -LRB- cord-009571-mygj2nd4 603 26 BMT BMT NNP cord-009571-mygj2nd4 603 27 ) ) -RRB- cord-009571-mygj2nd4 603 28 . . . cord-009571-mygj2nd4 604 1 Five five CD cord-009571-mygj2nd4 604 2 such such JJ cord-009571-mygj2nd4 604 3 subjects subject NNS cord-009571-mygj2nd4 604 4 , , , cord-009571-mygj2nd4 604 5 who who WP cord-009571-mygj2nd4 604 6 lived live VBD cord-009571-mygj2nd4 604 7 an an DT cord-009571-mygj2nd4 604 8 average average NN cord-009571-mygj2nd4 604 9 of of IN cord-009571-mygj2nd4 604 10 19 19 CD cord-009571-mygj2nd4 604 11 months month NNS cord-009571-mygj2nd4 604 12 post post NN cord-009571-mygj2nd4 604 13 - - NN cord-009571-mygj2nd4 604 14 BMT BMT NNP cord-009571-mygj2nd4 604 15 , , , cord-009571-mygj2nd4 604 16 developed develop VBN cord-009571-mygj2nd4 604 17 sclerodermatous sclerodermatous JJ cord-009571-mygj2nd4 604 18 cutaneous cutaneous JJ cord-009571-mygj2nd4 604 19 involvement involvement NN cord-009571-mygj2nd4 604 20 and and CC cord-009571-mygj2nd4 604 21 also also RB cord-009571-mygj2nd4 604 22 underwent undergo VBD cord-009571-mygj2nd4 604 23 examination examination NN cord-009571-mygj2nd4 604 24 for for IN cord-009571-mygj2nd4 604 25 visceral visceral JJ cord-009571-mygj2nd4 604 26 complications complication NNS cord-009571-mygj2nd4 604 27 resembling resemble VBG cord-009571-mygj2nd4 604 28 PSS PSS NNP cord-009571-mygj2nd4 604 29 . . . cord-009571-mygj2nd4 605 1 At at IN cord-009571-mygj2nd4 605 2 present present JJ cord-009571-mygj2nd4 605 3 , , , cord-009571-mygj2nd4 605 4 2 2 CD cord-009571-mygj2nd4 605 5 are be VBP cord-009571-mygj2nd4 605 6 alive alive JJ cord-009571-mygj2nd4 605 7 and and CC cord-009571-mygj2nd4 605 8 3 3 CD cord-009571-mygj2nd4 605 9 have have VBP cord-009571-mygj2nd4 605 10 died die VBN cord-009571-mygj2nd4 605 11 . . . cord-009571-mygj2nd4 606 1 We -PRON- PRP cord-009571-mygj2nd4 606 2 compared compare VBD cord-009571-mygj2nd4 606 3 their -PRON- PRP$ cord-009571-mygj2nd4 606 4 findings finding NNS cord-009571-mygj2nd4 606 5 with with IN cord-009571-mygj2nd4 606 6 the the DT cord-009571-mygj2nd4 606 7 findings finding NNS cord-009571-mygj2nd4 606 8 in in IN cord-009571-mygj2nd4 606 9 49 49 CD cord-009571-mygj2nd4 606 10 well well RB cord-009571-mygj2nd4 606 11 - - HYPH cord-009571-mygj2nd4 606 12 characterized characterize VBN cord-009571-mygj2nd4 606 13 patients patient NNS cord-009571-mygj2nd4 606 14 with with IN cord-009571-mygj2nd4 606 15 scleroderma scleroderma NNS cord-009571-mygj2nd4 606 16 to to TO cord-009571-mygj2nd4 606 17 ascertain ascertain VB cord-009571-mygj2nd4 606 18 the the DT cord-009571-mygj2nd4 606 19 similarities similarity NNS cord-009571-mygj2nd4 606 20 and and CC cord-009571-mygj2nd4 606 21 differences difference NNS cord-009571-mygj2nd4 606 22 between between IN cord-009571-mygj2nd4 606 23 these these DT cord-009571-mygj2nd4 606 24 two two CD cord-009571-mygj2nd4 606 25 groups group NNS cord-009571-mygj2nd4 606 26 . . . cord-009571-mygj2nd4 607 1 Taut taut JJ cord-009571-mygj2nd4 607 2 hidebound hidebound JJ cord-009571-mygj2nd4 607 3 skin skin NN cord-009571-mygj2nd4 607 4 was be VBD cord-009571-mygj2nd4 607 5 found find VBN cord-009571-mygj2nd4 607 6 in in IN cord-009571-mygj2nd4 607 7 all all DT cord-009571-mygj2nd4 607 8 patients patient NNS cord-009571-mygj2nd4 607 9 in in IN cord-009571-mygj2nd4 607 10 both both DT cord-009571-mygj2nd4 607 11 populations population NNS cord-009571-mygj2nd4 607 12 and and CC cord-009571-mygj2nd4 607 13 selected select VBN cord-009571-mygj2nd4 607 14 skin skin NN cord-009571-mygj2nd4 607 15 biopsies biopsy NNS cord-009571-mygj2nd4 607 16 were be VBD cord-009571-mygj2nd4 607 17 also also RB cord-009571-mygj2nd4 607 18 similar similar JJ cord-009571-mygj2nd4 607 19 . . . cord-009571-mygj2nd4 608 1 Restrictive restrictive JJ cord-009571-mygj2nd4 608 2 lung lung NN cord-009571-mygj2nd4 608 3 disease disease NN cord-009571-mygj2nd4 608 4 , , , cord-009571-mygj2nd4 608 5 characterized characterize VBN cord-009571-mygj2nd4 608 6 by by IN cord-009571-mygj2nd4 608 7 decreased decrease VBN cord-009571-mygj2nd4 608 8 vital vital JJ cord-009571-mygj2nd4 608 9 capacities capacity NNS cord-009571-mygj2nd4 608 10 and and CC cord-009571-mygj2nd4 608 11 diffusing diffuse VBG cord-009571-mygj2nd4 608 12 capacities capacity NNS cord-009571-mygj2nd4 608 13 , , , cord-009571-mygj2nd4 608 14 was be VBD cord-009571-mygj2nd4 608 15 found find VBN cord-009571-mygj2nd4 608 16 in in IN cord-009571-mygj2nd4 608 17 88 88 CD cord-009571-mygj2nd4 608 18 % % NN cord-009571-mygj2nd4 608 19 of of IN cord-009571-mygj2nd4 608 20 the the DT cord-009571-mygj2nd4 608 21 PSS PSS NNP cord-009571-mygj2nd4 608 22 patients patient NNS cord-009571-mygj2nd4 608 23 and and CC cord-009571-mygj2nd4 608 24 in in IN cord-009571-mygj2nd4 608 25 4/5 4/5 CD cord-009571-mygj2nd4 608 26 ( ( -LRB- cord-009571-mygj2nd4 608 27 8Wo 8wo NN cord-009571-mygj2nd4 608 28 ) ) -RRB- cord-009571-mygj2nd4 608 29 of of IN cord-009571-mygj2nd4 608 30 the the DT cord-009571-mygj2nd4 608 31 BMT BMT NNP cord-009571-mygj2nd4 608 32 group group NN cord-009571-mygj2nd4 608 33 . . . cord-009571-mygj2nd4 609 1 Cardiac cardiac JJ cord-009571-mygj2nd4 609 2 disease disease NN cord-009571-mygj2nd4 609 3 and and CC cord-009571-mygj2nd4 609 4 Raynaud Raynaud NNP cord-009571-mygj2nd4 609 5 's 's POS cord-009571-mygj2nd4 609 6 phenomenon phenomenon NN cord-009571-mygj2nd4 609 7 , , , cord-009571-mygj2nd4 609 8 similar similar JJ cord-009571-mygj2nd4 609 9 to to IN cord-009571-mygj2nd4 609 10 that that DT cord-009571-mygj2nd4 609 11 found find VBN cord-009571-mygj2nd4 609 12 in in IN cord-009571-mygj2nd4 609 13 the the DT cord-009571-mygj2nd4 609 14 PSS PSS NNP cord-009571-mygj2nd4 609 15 group group NN cord-009571-mygj2nd4 609 16 , , , cord-009571-mygj2nd4 609 17 were be VBD cord-009571-mygj2nd4 609 18 noted note VBN cord-009571-mygj2nd4 609 19 in in IN cord-009571-mygj2nd4 609 20 one one CD cord-009571-mygj2nd4 609 21 post post JJ cord-009571-mygj2nd4 609 22 - - JJ cord-009571-mygj2nd4 609 23 BMT bmt JJ cord-009571-mygj2nd4 609 24 patient patient NN cord-009571-mygj2nd4 609 25 , , , cord-009571-mygj2nd4 609 26 and and CC cord-009571-mygj2nd4 609 27 pathologic pathologic JJ cord-009571-mygj2nd4 609 28 evidence evidence NN cord-009571-mygj2nd4 609 29 of of IN cord-009571-mygj2nd4 609 30 PSS PSS NNP cord-009571-mygj2nd4 609 31 - - HYPH cord-009571-mygj2nd4 609 32 like like JJ cord-009571-mygj2nd4 609 33 esophageal esophageal JJ cord-009571-mygj2nd4 609 34 involvement involvement NN cord-009571-mygj2nd4 609 35 was be VBD cord-009571-mygj2nd4 609 36 found find VBN cord-009571-mygj2nd4 609 37 in in IN cord-009571-mygj2nd4 609 38 another another DT cord-009571-mygj2nd4 609 39 . . . cord-009571-mygj2nd4 610 1 In in IN cord-009571-mygj2nd4 610 2 both both CC cord-009571-mygj2nd4 610 3 the the DT cord-009571-mygj2nd4 610 4 BMT BMT NNP cord-009571-mygj2nd4 610 5 and and CC cord-009571-mygj2nd4 610 6 PSS PSS NNP cord-009571-mygj2nd4 610 7 groups group NNS cord-009571-mygj2nd4 610 8 , , , cord-009571-mygj2nd4 610 9 the the DT cord-009571-mygj2nd4 610 10 responses response NNS cord-009571-mygj2nd4 610 11 of of IN cord-009571-mygj2nd4 610 12 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 610 13 to to IN cord-009571-mygj2nd4 610 14 suboptimal suboptimal JJ cord-009571-mygj2nd4 610 15 concentrations concentration NNS cord-009571-mygj2nd4 610 16 of of IN cord-009571-mygj2nd4 610 17 PHA PHA NNP cord-009571-mygj2nd4 610 18 were be VBD cord-009571-mygj2nd4 610 19 d d NNP cord-009571-mygj2nd4 610 20 e e NN cord-009571-mygj2nd4 610 21 pressed press VBN cord-009571-mygj2nd4 610 22 , , , cord-009571-mygj2nd4 610 23 while while IN cord-009571-mygj2nd4 610 24 complement complement JJ cord-009571-mygj2nd4 610 25 levels level NNS cord-009571-mygj2nd4 610 26 , , , cord-009571-mygj2nd4 610 27 screening screening NN cord-009571-mygj2nd4 610 28 tests test NNS cord-009571-mygj2nd4 610 29 for for IN cord-009571-mygj2nd4 610 30 autoantibodies autoantibody NNS cord-009571-mygj2nd4 610 31 and and CC cord-009571-mygj2nd4 610 32 circulating circulate VBG cord-009571-mygj2nd4 610 33 levels level NNS cord-009571-mygj2nd4 610 34 of of IN cord-009571-mygj2nd4 610 35 IgA IgA NNP cord-009571-mygj2nd4 610 36 and and CC cord-009571-mygj2nd4 610 37 IgM IgM NNP cord-009571-mygj2nd4 610 38 were be VBD cord-009571-mygj2nd4 610 39 essentially essentially RB cord-009571-mygj2nd4 610 40 normal normal JJ cord-009571-mygj2nd4 610 41 . . . cord-009571-mygj2nd4 611 1 The the DT cord-009571-mygj2nd4 611 2 frequency frequency NN cord-009571-mygj2nd4 611 3 of of IN cord-009571-mygj2nd4 611 4 patients patient NNS cord-009571-mygj2nd4 611 5 with with IN cord-009571-mygj2nd4 611 6 abnormal abnormal JJ cord-009571-mygj2nd4 611 7 ANA ANA NNP cord-009571-mygj2nd4 611 8 and and CC cord-009571-mygj2nd4 611 9 DNA dna NN cord-009571-mygj2nd4 611 10 - - HYPH cord-009571-mygj2nd4 611 11 bindings binding NNS cord-009571-mygj2nd4 611 12 was be VBD cord-009571-mygj2nd4 611 13 higher high JJR cord-009571-mygj2nd4 611 14 in in IN cord-009571-mygj2nd4 611 15 the the DT cord-009571-mygj2nd4 611 16 PSS PSS NNP cord-009571-mygj2nd4 611 17 group group NN cord-009571-mygj2nd4 611 18 than than IN cord-009571-mygj2nd4 611 19 in in IN cord-009571-mygj2nd4 611 20 the the DT cord-009571-mygj2nd4 611 21 BMT BMT NNP cord-009571-mygj2nd4 611 22 group group NN cord-009571-mygj2nd4 611 23 . . . cord-009571-mygj2nd4 612 1 The the DT cord-009571-mygj2nd4 612 2 incidence incidence NN cord-009571-mygj2nd4 612 3 of of IN cord-009571-mygj2nd4 612 4 abnormal abnormal JJ cord-009571-mygj2nd4 612 5 levels level NNS cord-009571-mygj2nd4 612 6 of of IN cord-009571-mygj2nd4 612 7 immune immune JJ cord-009571-mygj2nd4 612 8 complexes complex NNS cord-009571-mygj2nd4 612 9 , , , cord-009571-mygj2nd4 612 10 IgG igg NN cord-009571-mygj2nd4 612 11 levels level NNS cord-009571-mygj2nd4 612 12 , , , cord-009571-mygj2nd4 612 13 anergy anergy NNP cord-009571-mygj2nd4 612 14 , , , cord-009571-mygj2nd4 612 15 and and CC cord-009571-mygj2nd4 612 16 decreased decrease VBD cord-009571-mygj2nd4 612 17 percentages percentage NNS cord-009571-mygj2nd4 612 18 of of IN cord-009571-mygj2nd4 612 19 B b NN cord-009571-mygj2nd4 612 20 - - : cord-009571-mygj2nd4 612 21 and and CC cord-009571-mygj2nd4 612 22 T T NNP cord-009571-mygj2nd4 612 23 - - HYPH cord-009571-mygj2nd4 612 24 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 612 25 was be VBD cord-009571-mygj2nd4 612 26 higher high JJR cord-009571-mygj2nd4 612 27 in in IN cord-009571-mygj2nd4 612 28 the the DT cord-009571-mygj2nd4 612 29 BMT BMT NNP cord-009571-mygj2nd4 612 30 patients patient NNS cord-009571-mygj2nd4 612 31 than than IN cord-009571-mygj2nd4 612 32 in in IN cord-009571-mygj2nd4 612 33 those those DT cord-009571-mygj2nd4 612 34 with with IN cord-009571-mygj2nd4 612 35 PSS PSS NNP cord-009571-mygj2nd4 612 36 . . . cord-009571-mygj2nd4 613 1 Even even RB cord-009571-mygj2nd4 613 2 though though IN cord-009571-mygj2nd4 613 3 only only RB cord-009571-mygj2nd4 613 4 19 19 CD cord-009571-mygj2nd4 613 5 months month NNS cord-009571-mygj2nd4 613 6 have have VBP cord-009571-mygj2nd4 613 7 elapsed elapse VBN cord-009571-mygj2nd4 613 8 since since IN cord-009571-mygj2nd4 613 9 transplantation transplantation NN cord-009571-mygj2nd4 613 10 , , , cord-009571-mygj2nd4 613 11 these these DT cord-009571-mygj2nd4 613 12 5 5 CD cord-009571-mygj2nd4 613 13 post post JJ cord-009571-mygj2nd4 613 14 - - JJ cord-009571-mygj2nd4 613 15 BMT bmt JJ cord-009571-mygj2nd4 613 16 patients patient NNS cord-009571-mygj2nd4 613 17 have have VBP cord-009571-mygj2nd4 613 18 begun begin VBN cord-009571-mygj2nd4 613 19 to to TO cord-009571-mygj2nd4 613 20 develop develop VB cord-009571-mygj2nd4 613 21 signs sign NNS cord-009571-mygj2nd4 613 22 and and CC cord-009571-mygj2nd4 613 23 symptoms symptom NNS cord-009571-mygj2nd4 613 24 of of IN cord-009571-mygj2nd4 613 25 a a DT cord-009571-mygj2nd4 613 26 PSS PSS NNP cord-009571-mygj2nd4 613 27 - - HYPH cord-009571-mygj2nd4 613 28 like like JJ cord-009571-mygj2nd4 613 29 disease disease NN cord-009571-mygj2nd4 613 30 . . . cord-009571-mygj2nd4 614 1 We -PRON- PRP cord-009571-mygj2nd4 614 2 suggest suggest VBP cord-009571-mygj2nd4 614 3 that that IN cord-009571-mygj2nd4 614 4 BMT BMT NNP cord-009571-mygj2nd4 614 5 bears bear VBZ cord-009571-mygj2nd4 614 6 closer close JJR cord-009571-mygj2nd4 614 7 examination examination NN cord-009571-mygj2nd4 614 8 as as IN cord-009571-mygj2nd4 614 9 a a DT cord-009571-mygj2nd4 614 10 model model NN cord-009571-mygj2nd4 614 11 for for IN cord-009571-mygj2nd4 614 12 PSS PSS NNP cord-009571-mygj2nd4 614 13 . . . cord-009571-mygj2nd4 615 1 This this DT cord-009571-mygj2nd4 615 2 study study NN cord-009571-mygj2nd4 615 3 was be VBD cord-009571-mygj2nd4 615 4 initiated initiate VBN cord-009571-mygj2nd4 615 5 to to TO cord-009571-mygj2nd4 615 6 further further RB cord-009571-mygj2nd4 615 7 investigate investigate VB cord-009571-mygj2nd4 615 8 the the DT cord-009571-mygj2nd4 615 9 inhibitory inhibitory JJ cord-009571-mygj2nd4 615 10 effect effect NN cord-009571-mygj2nd4 615 11 of of IN cord-009571-mygj2nd4 615 12 IgM IgM NNP cord-009571-mygj2nd4 615 13 rheumatoid rheumatoid NNP cord-009571-mygj2nd4 615 14 factor factor NN cord-009571-mygj2nd4 615 15 ( ( -LRB- cord-009571-mygj2nd4 615 16 RF RF NNP cord-009571-mygj2nd4 615 17 ) ) -RRB- cord-009571-mygj2nd4 615 18 in in IN cord-009571-mygj2nd4 615 19 an an DT cord-009571-mygj2nd4 615 20 antibodydependent antibodydependent NN cord-009571-mygj2nd4 615 21 cell cell NN cord-009571-mygj2nd4 615 22 - - HYPH cord-009571-mygj2nd4 615 23 mediated mediate VBN cord-009571-mygj2nd4 615 24 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 615 25 ( ( -LRB- cord-009571-mygj2nd4 615 26 ADCC ADCC NNP cord-009571-mygj2nd4 615 27 ) ) -RRB- cord-009571-mygj2nd4 615 28 assay assay NN cord-009571-mygj2nd4 615 29 . . . cord-009571-mygj2nd4 616 1 This this DT cord-009571-mygj2nd4 616 2 assay assay NN cord-009571-mygj2nd4 616 3 employs employ VBZ cord-009571-mygj2nd4 616 4 human human JJ cord-009571-mygj2nd4 616 5 peripheral peripheral JJ cord-009571-mygj2nd4 616 6 blood blood NN cord-009571-mygj2nd4 616 7 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 616 8 as as IN cord-009571-mygj2nd4 616 9 effector effector NN cord-009571-mygj2nd4 616 10 cells cell NNS cord-009571-mygj2nd4 616 11 and and CC cord-009571-mygj2nd4 616 12 IgG IgG NNP cord-009571-mygj2nd4 616 13 or or CC cord-009571-mygj2nd4 616 14 IgM IgM NNP cord-009571-mygj2nd4 616 15 sensitized sensitize VBD cord-009571-mygj2nd4 616 16 , , , cord-009571-mygj2nd4 616 17 51Cr 51cr CD cord-009571-mygj2nd4 616 18 labeled label VBD cord-009571-mygj2nd4 616 19 ox ox JJ cord-009571-mygj2nd4 616 20 erythrocytes erythrocyte NNS cord-009571-mygj2nd4 616 21 as as IN cord-009571-mygj2nd4 616 22 target target NN cord-009571-mygj2nd4 616 23 cells cell NNS cord-009571-mygj2nd4 616 24 . . . cord-009571-mygj2nd4 617 1 Serum serum NN cord-009571-mygj2nd4 617 2 and and CC cord-009571-mygj2nd4 617 3 synovial synovial JJ cord-009571-mygj2nd4 617 4 fluid fluid NN cord-009571-mygj2nd4 617 5 were be VBD cord-009571-mygj2nd4 617 6 obtained obtain VBN cord-009571-mygj2nd4 617 7 from from IN cord-009571-mygj2nd4 617 8 patients patient NNS cord-009571-mygj2nd4 617 9 with with IN cord-009571-mygj2nd4 617 10 seropositive seropositive JJ cord-009571-mygj2nd4 617 11 classic classic JJ cord-009571-mygj2nd4 617 12 rheumatoid rheumatoid NN cord-009571-mygj2nd4 617 13 arthritis arthritis NN cord-009571-mygj2nd4 617 14 ( ( -LRB- cord-009571-mygj2nd4 617 15 RA RA NNP cord-009571-mygj2nd4 617 16 ) ) -RRB- cord-009571-mygj2nd4 617 17 and and CC cord-009571-mygj2nd4 617 18 heat heat NN cord-009571-mygj2nd4 617 19 inactivated inactivate VBN cord-009571-mygj2nd4 617 20 . . . cord-009571-mygj2nd4 618 1 RF RF NNP cord-009571-mygj2nd4 618 2 was be VBD cord-009571-mygj2nd4 618 3 prepared prepare VBN cord-009571-mygj2nd4 618 4 by by IN cord-009571-mygj2nd4 618 5 dialyzing dialyze VBG cord-009571-mygj2nd4 618 6 the the DT cord-009571-mygj2nd4 618 7 sera sera NNP cord-009571-mygj2nd4 618 8 and and CC cord-009571-mygj2nd4 618 9 synovial synovial JJ cord-009571-mygj2nd4 618 10 fluid fluid NN cord-009571-mygj2nd4 618 11 against against IN cord-009571-mygj2nd4 618 12 sodium sodium NN cord-009571-mygj2nd4 618 13 acetate acetate NN cord-009571-mygj2nd4 618 14 buffer buffer NN cord-009571-mygj2nd4 618 15 ( ( -LRB- cord-009571-mygj2nd4 618 16 pH pH NNP cord-009571-mygj2nd4 618 17 4.0 4.0 CD cord-009571-mygj2nd4 618 18 ) ) -RRB- cord-009571-mygj2nd4 618 19 , , , cord-009571-mygj2nd4 618 20 fractionating fractionate VBG cord-009571-mygj2nd4 618 21 on on IN cord-009571-mygj2nd4 618 22 Sephadex Sephadex NNP cord-009571-mygj2nd4 618 23 G-200 g-200 IN cord-009571-mygj2nd4 618 24 with with IN cord-009571-mygj2nd4 618 25 the the DT cord-009571-mygj2nd4 618 26 same same JJ cord-009571-mygj2nd4 618 27 buffer buffer NN cord-009571-mygj2nd4 618 28 and and CC cord-009571-mygj2nd4 618 29 pooling pool VBG cord-009571-mygj2nd4 618 30 the the DT cord-009571-mygj2nd4 618 31 fractions fraction NNS cord-009571-mygj2nd4 618 32 constituting constitute VBG cord-009571-mygj2nd4 618 33 the the DT cord-009571-mygj2nd4 618 34 leading leading JJ cord-009571-mygj2nd4 618 35 side side NN cord-009571-mygj2nd4 618 36 of of IN cord-009571-mygj2nd4 618 37 the the DT cord-009571-mygj2nd4 618 38 19s 19s NNPS cord-009571-mygj2nd4 618 39 peak peak NN cord-009571-mygj2nd4 618 40 , , , cord-009571-mygj2nd4 618 41 dialyzing dialyze VBG cord-009571-mygj2nd4 618 42 against against IN cord-009571-mygj2nd4 618 43 PBS PBS NNP cord-009571-mygj2nd4 618 44 and and CC cord-009571-mygj2nd4 618 45 further further JJ cord-009571-mygj2nd4 618 46 purifying purify VBG cord-009571-mygj2nd4 618 47 by by IN cord-009571-mygj2nd4 618 48 passage passage NN cord-009571-mygj2nd4 618 49 over over IN cord-009571-mygj2nd4 618 50 an an DT cord-009571-mygj2nd4 618 51 IgG igg NN cord-009571-mygj2nd4 618 52 - - HYPH cord-009571-mygj2nd4 618 53 coupled couple VBN cord-009571-mygj2nd4 618 54 Sepharose Sepharose NNP cord-009571-mygj2nd4 618 55 4B 4b CD cord-009571-mygj2nd4 618 56 column column NN cord-009571-mygj2nd4 618 57 and and CC cord-009571-mygj2nd4 618 58 eluting elute VBG cord-009571-mygj2nd4 618 59 with with IN cord-009571-mygj2nd4 618 60 acid acid NN cord-009571-mygj2nd4 618 61 . . . cord-009571-mygj2nd4 619 1 This this DT cord-009571-mygj2nd4 619 2 IgM IgM NNP cord-009571-mygj2nd4 619 3 - - HYPH cord-009571-mygj2nd4 619 4 RF RF NNP cord-009571-mygj2nd4 619 5 was be VBD cord-009571-mygj2nd4 619 6 tryspin tryspin NNP cord-009571-mygj2nd4 619 7 digested digest VBN cord-009571-mygj2nd4 619 8 ( ( -LRB- cord-009571-mygj2nd4 619 9 enzymexubstrate enzymexubstrate NNP cord-009571-mygj2nd4 619 10 ratio ratio NN cord-009571-mygj2nd4 619 11 = = SYM cord-009571-mygj2nd4 619 12 1 1 CD cord-009571-mygj2nd4 619 13 : : : cord-009571-mygj2nd4 619 14 50 50 CD cord-009571-mygj2nd4 619 15 ) ) -RRB- cord-009571-mygj2nd4 619 16 at at IN cord-009571-mygj2nd4 619 17 60 60 CD cord-009571-mygj2nd4 619 18 ° ° NN cord-009571-mygj2nd4 619 19 C c NN cord-009571-mygj2nd4 619 20 for for IN cord-009571-mygj2nd4 619 21 20 20 CD cord-009571-mygj2nd4 619 22 minutes minute NNS cord-009571-mygj2nd4 619 23 and and CC cord-009571-mygj2nd4 619 24 the the DT cord-009571-mygj2nd4 619 25 reaction reaction NN cord-009571-mygj2nd4 619 26 stopped stop VBD cord-009571-mygj2nd4 619 27 by by IN cord-009571-mygj2nd4 619 28 adding add VBG cord-009571-mygj2nd4 619 29 soybean soybean NN cord-009571-mygj2nd4 619 30 trypsin trypsin NN cord-009571-mygj2nd4 619 31 inhibitor inhibitor NN cord-009571-mygj2nd4 619 32 . . . cord-009571-mygj2nd4 620 1 The the DT cord-009571-mygj2nd4 620 2 fragments fragment NNS cord-009571-mygj2nd4 620 3 were be VBD cord-009571-mygj2nd4 620 4 fractionated fractionate VBN cord-009571-mygj2nd4 620 5 on on IN cord-009571-mygj2nd4 620 6 BioGel BioGel NNP cord-009571-mygj2nd4 620 7 A5 A5 NNP cord-009571-mygj2nd4 620 8 m m NNP cord-009571-mygj2nd4 620 9 to to TO cord-009571-mygj2nd4 620 10 separate separate VB cord-009571-mygj2nd4 620 11 undigested undigested JJ cord-009571-mygj2nd4 620 12 IgM igm NN cord-009571-mygj2nd4 620 13 , , , cord-009571-mygj2nd4 620 14 Fc Fc NNP cord-009571-mygj2nd4 620 15 , , , cord-009571-mygj2nd4 620 16 p p NNP cord-009571-mygj2nd4 620 17 and and CC cord-009571-mygj2nd4 620 18 Fab Fab NNP cord-009571-mygj2nd4 620 19 . . . cord-009571-mygj2nd4 621 1 The the DT cord-009571-mygj2nd4 621 2 IgM IgM NNP cord-009571-mygj2nd4 621 3 - - HYPH cord-009571-mygj2nd4 621 4 RF RF NNP cord-009571-mygj2nd4 621 5 , , , cord-009571-mygj2nd4 621 6 Fc Fc NNP cord-009571-mygj2nd4 621 7 & & CC cord-009571-mygj2nd4 621 8 and and CC cord-009571-mygj2nd4 621 9 Fab fab JJ cord-009571-mygj2nd4 621 10 fragments fragment NNS cord-009571-mygj2nd4 621 11 were be VBD cord-009571-mygj2nd4 621 12 tested test VBN cord-009571-mygj2nd4 621 13 for for IN cord-009571-mygj2nd4 621 14 inhibitory inhibitory JJ cord-009571-mygj2nd4 621 15 capacity capacity NN cord-009571-mygj2nd4 621 16 in in IN cord-009571-mygj2nd4 621 17 IgM IgM NNP cord-009571-mygj2nd4 621 18 and and CC cord-009571-mygj2nd4 621 19 IgG IgG NNP cord-009571-mygj2nd4 621 20 induced induce VBD cord-009571-mygj2nd4 621 21 ADCC ADCC NNP cord-009571-mygj2nd4 621 22 at at IN cord-009571-mygj2nd4 621 23 both both CC cord-009571-mygj2nd4 621 24 the the DT cord-009571-mygj2nd4 621 25 effector effector NN cord-009571-mygj2nd4 621 26 and and CC cord-009571-mygj2nd4 621 27 target target NN cord-009571-mygj2nd4 621 28 cell cell NN cord-009571-mygj2nd4 621 29 levels level NNS cord-009571-mygj2nd4 621 30 . . . cord-009571-mygj2nd4 622 1 It -PRON- PRP cord-009571-mygj2nd4 622 2 was be VBD cord-009571-mygj2nd4 622 3 found find VBN cord-009571-mygj2nd4 622 4 that that IN cord-009571-mygj2nd4 622 5 IgM IgM NNP cord-009571-mygj2nd4 622 6 and and CC cord-009571-mygj2nd4 622 7 IgG IgG NNP cord-009571-mygj2nd4 622 8 induced induce VBD cord-009571-mygj2nd4 622 9 ADCC ADCC NNP cord-009571-mygj2nd4 622 10 was be VBD cord-009571-mygj2nd4 622 11 inhibited inhibit VBN cord-009571-mygj2nd4 622 12 by by IN cord-009571-mygj2nd4 622 13 IgM IgM NNP cord-009571-mygj2nd4 622 14 - - HYPH cord-009571-mygj2nd4 622 15 RF RF NNP cord-009571-mygj2nd4 622 16 and and CC cord-009571-mygj2nd4 622 17 its -PRON- PRP$ cord-009571-mygj2nd4 622 18 tryspin tryspin NNP cord-009571-mygj2nd4 622 19 digest digest NN cord-009571-mygj2nd4 622 20 fragments fragment NNS cord-009571-mygj2nd4 622 21 . . . cord-009571-mygj2nd4 623 1 Inhibition inhibition NN cord-009571-mygj2nd4 623 2 at at IN cord-009571-mygj2nd4 623 3 the the DT cord-009571-mygj2nd4 623 4 effector effector NN cord-009571-mygj2nd4 623 5 cell cell NN cord-009571-mygj2nd4 623 6 level level NN cord-009571-mygj2nd4 623 7 was be VBD cord-009571-mygj2nd4 623 8 achieved achieve VBN cord-009571-mygj2nd4 623 9 by by IN cord-009571-mygj2nd4 623 10 RF RF NNP cord-009571-mygj2nd4 623 11 Fc Fc NNP cord-009571-mygj2nd4 623 12 & & CC cord-009571-mygj2nd4 623 13 and and CC cord-009571-mygj2nd4 623 14 Fab Fab NNP cord-009571-mygj2nd4 623 15 whereas whereas IN cord-009571-mygj2nd4 623 16 inhibition inhibition NN cord-009571-mygj2nd4 623 17 of of IN cord-009571-mygj2nd4 623 18 the the DT cord-009571-mygj2nd4 623 19 target target NN cord-009571-mygj2nd4 623 20 cell cell NN cord-009571-mygj2nd4 623 21 level level NN cord-009571-mygj2nd4 623 22 was be VBD cord-009571-mygj2nd4 623 23 achieved achieve VBN cord-009571-mygj2nd4 623 24 only only RB cord-009571-mygj2nd4 623 25 by by IN cord-009571-mygj2nd4 623 26 RF RF NNP cord-009571-mygj2nd4 623 27 Fab Fab NNP cord-009571-mygj2nd4 623 28 . . . cord-009571-mygj2nd4 624 1 These these DT cord-009571-mygj2nd4 624 2 results result NNS cord-009571-mygj2nd4 624 3 indicate indicate VBP cord-009571-mygj2nd4 624 4 that that IN cord-009571-mygj2nd4 624 5 R R NNP cord-009571-mygj2nd4 624 6 F F NNP cord-009571-mygj2nd4 624 7 may may MD cord-009571-mygj2nd4 624 8 inhibit inhibit VB cord-009571-mygj2nd4 624 9 ADCC ADCC NNP cord-009571-mygj2nd4 624 10 at at IN cord-009571-mygj2nd4 624 11 the the DT cord-009571-mygj2nd4 624 12 effector effector NN cord-009571-mygj2nd4 624 13 or or CC cord-009571-mygj2nd4 624 14 target target NN cord-009571-mygj2nd4 624 15 cell cell NN cord-009571-mygj2nd4 624 16 level level NN cord-009571-mygj2nd4 624 17 and and CC cord-009571-mygj2nd4 624 18 thus thus RB cord-009571-mygj2nd4 624 19 modulate modulate VB cord-009571-mygj2nd4 624 20 an an DT cord-009571-mygj2nd4 624 21 immune immune JJ cord-009571-mygj2nd4 624 22 response response NN cord-009571-mygj2nd4 624 23 that that WDT cord-009571-mygj2nd4 624 24 is be VBZ cord-009571-mygj2nd4 624 25 of of IN cord-009571-mygj2nd4 624 26 potential potential JJ cord-009571-mygj2nd4 624 27 importance importance NN cord-009571-mygj2nd4 624 28 in in IN cord-009571-mygj2nd4 624 29 immune immune JJ cord-009571-mygj2nd4 624 30 - - HYPH cord-009571-mygj2nd4 624 31 complex complex JJ cord-009571-mygj2nd4 624 32 disease disease NN cord-009571-mygj2nd4 624 33 . . . cord-009571-mygj2nd4 625 1 Patients patient NNS cord-009571-mygj2nd4 625 2 with with IN cord-009571-mygj2nd4 625 3 seropositive seropositive JJ cord-009571-mygj2nd4 625 4 rheumatoid rheumatoid NN cord-009571-mygj2nd4 625 5 arthritis arthritis NN cord-009571-mygj2nd4 625 6 ( ( -LRB- cord-009571-mygj2nd4 625 7 RA RA NNP cord-009571-mygj2nd4 625 8 ) ) -RRB- cord-009571-mygj2nd4 625 9 of of IN cord-009571-mygj2nd4 625 10 adult adult NN cord-009571-mygj2nd4 625 11 - - HYPH cord-009571-mygj2nd4 625 12 onset onset NN cord-009571-mygj2nd4 625 13 were be VBD cord-009571-mygj2nd4 625 14 compared compare VBN cord-009571-mygj2nd4 625 15 to to IN cord-009571-mygj2nd4 625 16 control control VB cord-009571-mygj2nd4 625 17 groups group NNS cord-009571-mygj2nd4 625 18 by by IN cord-009571-mygj2nd4 625 19 utilizing utilize VBG cord-009571-mygj2nd4 625 20 two two CD cord-009571-mygj2nd4 625 21 primary primary JJ cord-009571-mygj2nd4 625 22 histocompatibility histocompatibility NN cord-009571-mygj2nd4 625 23 procedures procedure NNS cord-009571-mygj2nd4 625 24 , , , cord-009571-mygj2nd4 625 25 B b NN cord-009571-mygj2nd4 625 26 - - HYPH cord-009571-mygj2nd4 625 27 cell cell NN cord-009571-mygj2nd4 625 28 ( ( -LRB- cord-009571-mygj2nd4 625 29 Ia Ia NNP cord-009571-mygj2nd4 625 30 ) ) -RRB- cord-009571-mygj2nd4 625 31 alloantigen alloantigen NN cord-009571-mygj2nd4 625 32 typing typing NN cord-009571-mygj2nd4 625 33 and and CC cord-009571-mygj2nd4 625 34 mixed mixed JJ cord-009571-mygj2nd4 625 35 lymphocyte lymphocyte NN cord-009571-mygj2nd4 625 36 culture culture NN cord-009571-mygj2nd4 625 37 ( ( -LRB- cord-009571-mygj2nd4 625 38 MLC MLC NNP cord-009571-mygj2nd4 625 39 ) ) -RRB- cord-009571-mygj2nd4 625 40 reactivity reactivity NN cord-009571-mygj2nd4 625 41 . . . cord-009571-mygj2nd4 626 1 By by IN cord-009571-mygj2nd4 626 2 use use NN cord-009571-mygj2nd4 626 3 of of IN cord-009571-mygj2nd4 626 4 a a DT cord-009571-mygj2nd4 626 5 two two CD cord-009571-mygj2nd4 626 6 - - HYPH cord-009571-mygj2nd4 626 7 stage stage NN cord-009571-mygj2nd4 626 8 microcytotoxicity microcytotoxicity NN cord-009571-mygj2nd4 626 9 assay assay NN cord-009571-mygj2nd4 626 10 with with IN cord-009571-mygj2nd4 626 11 a a DT cord-009571-mygj2nd4 626 12 panel panel NN cord-009571-mygj2nd4 626 13 of of IN cord-009571-mygj2nd4 626 14 30 30 CD cord-009571-mygj2nd4 626 15 alloantisera alloantisera NNP cord-009571-mygj2nd4 626 16 , , , cord-009571-mygj2nd4 626 17 the the DT cord-009571-mygj2nd4 626 18 frequencies frequency NNS cord-009571-mygj2nd4 626 19 of of IN cord-009571-mygj2nd4 626 20 various various JJ cord-009571-mygj2nd4 626 21 B b NN cord-009571-mygj2nd4 626 22 - - HYPH cord-009571-mygj2nd4 626 23 cell cell NN cord-009571-mygj2nd4 626 24 alloantigens alloantigen NNS cord-009571-mygj2nd4 626 25 in in IN cord-009571-mygj2nd4 626 26 patients patient NNS cord-009571-mygj2nd4 626 27 with with IN cord-009571-mygj2nd4 626 28 RA RA NNP cord-009571-mygj2nd4 626 29 were be VBD cord-009571-mygj2nd4 626 30 compared compare VBN cord-009571-mygj2nd4 626 31 to to IN cord-009571-mygj2nd4 626 32 those those DT cord-009571-mygj2nd4 626 33 of of IN cord-009571-mygj2nd4 626 34 control control NN cord-009571-mygj2nd4 626 35 populations population NNS cord-009571-mygj2nd4 626 36 , , , cord-009571-mygj2nd4 626 37 including include VBG cord-009571-mygj2nd4 626 38 patients patient NNS cord-009571-mygj2nd4 626 39 with with IN cord-009571-mygj2nd4 626 40 multiple multiple JJ cord-009571-mygj2nd4 626 41 sclerosis sclerosis NN cord-009571-mygj2nd4 626 42 . . . cord-009571-mygj2nd4 627 1 Three three CD cord-009571-mygj2nd4 627 2 B b NN cord-009571-mygj2nd4 627 3 - - HYPH cord-009571-mygj2nd4 627 4 cell cell NN cord-009571-mygj2nd4 627 5 alloantisera alloantisera NN cord-009571-mygj2nd4 627 6 were be VBD cord-009571-mygj2nd4 627 7 identified identify VBN cord-009571-mygj2nd4 627 8 that that WDT cord-009571-mygj2nd4 627 9 gave give VBD cord-009571-mygj2nd4 627 10 particularly particularly RB cord-009571-mygj2nd4 627 11 high high JJ cord-009571-mygj2nd4 627 12 frequencies frequency NNS cord-009571-mygj2nd4 627 13 of of IN cord-009571-mygj2nd4 627 14 reactivity reactivity NN cord-009571-mygj2nd4 627 15 with with IN cord-009571-mygj2nd4 627 16 RA RA NNP cord-009571-mygj2nd4 627 17 patients patient NNS cord-009571-mygj2nd4 627 18 . . . cord-009571-mygj2nd4 628 1 Delineation delineation NN cord-009571-mygj2nd4 628 2 of of IN cord-009571-mygj2nd4 628 3 the the DT cord-009571-mygj2nd4 628 4 specificity specificity NN cord-009571-mygj2nd4 628 5 of of IN cord-009571-mygj2nd4 628 6 these these DT cord-009571-mygj2nd4 628 7 3 3 CD cord-009571-mygj2nd4 628 8 alloantisera alloantisera NN cord-009571-mygj2nd4 628 9 on on IN cord-009571-mygj2nd4 628 10 a a DT cord-009571-mygj2nd4 628 11 panel panel NN cord-009571-mygj2nd4 628 12 of of IN cord-009571-mygj2nd4 628 13 36 36 CD cord-009571-mygj2nd4 628 14 B b NN cord-009571-mygj2nd4 628 15 - - HYPH cord-009571-mygj2nd4 628 16 cell cell NN cord-009571-mygj2nd4 628 17 lines line NNS cord-009571-mygj2nd4 628 18 derived derive VBN cord-009571-mygj2nd4 628 19 from from IN cord-009571-mygj2nd4 628 20 individuals individual NNS cord-009571-mygj2nd4 628 21 homozygous homozygous JJ cord-009571-mygj2nd4 628 22 for for IN cord-009571-mygj2nd4 628 23 MLC MLC NNP cord-009571-mygj2nd4 628 24 alleles allele NNS cord-009571-mygj2nd4 628 25 revealed reveal VBD cord-009571-mygj2nd4 628 26 that that IN cord-009571-mygj2nd4 628 27 reactions reaction NNS cord-009571-mygj2nd4 628 28 were be VBD cord-009571-mygj2nd4 628 29 obtained obtain VBN cord-009571-mygj2nd4 628 30 only only RB cord-009571-mygj2nd4 628 31 with with IN cord-009571-mygj2nd4 628 32 those those DT cord-009571-mygj2nd4 628 33 lines line NNS cord-009571-mygj2nd4 628 34 from from IN cord-009571-mygj2nd4 628 35 individuals individual NNS cord-009571-mygj2nd4 628 36 that that WDT cord-009571-mygj2nd4 628 37 were be VBD cord-009571-mygj2nd4 628 38 positive positive JJ cord-009571-mygj2nd4 628 39 for for IN cord-009571-mygj2nd4 628 40 HLA HLA NNP cord-009571-mygj2nd4 628 41 - - HYPH cord-009571-mygj2nd4 628 42 Dw4 dw4 NN cord-009571-mygj2nd4 628 43 , , , cord-009571-mygj2nd4 628 44 Dw7 dw7 CD cord-009571-mygj2nd4 628 45 , , , cord-009571-mygj2nd4 628 46 or or CC cord-009571-mygj2nd4 628 47 DwlO. DwlO. NNS cord-009571-mygj2nd4 629 1 Absorption absorption NN cord-009571-mygj2nd4 629 2 of of IN cord-009571-mygj2nd4 629 3 the the DT cord-009571-mygj2nd4 629 4 alloantisera alloantisera NN cord-009571-mygj2nd4 629 5 with with IN cord-009571-mygj2nd4 629 6 B b NN cord-009571-mygj2nd4 629 7 - - HYPH cord-009571-mygj2nd4 629 8 cell cell NN cord-009571-mygj2nd4 629 9 lines line NNS cord-009571-mygj2nd4 629 10 from from IN cord-009571-mygj2nd4 629 11 Dw4 dw4 NN cord-009571-mygj2nd4 629 12 , , , cord-009571-mygj2nd4 629 13 Dw7 dw7 CD cord-009571-mygj2nd4 629 14 , , , cord-009571-mygj2nd4 629 15 or or CC cord-009571-mygj2nd4 629 16 DwlO DwlO NNP cord-009571-mygj2nd4 629 17 positive positive JJ cord-009571-mygj2nd4 629 18 individuals individual NNS cord-009571-mygj2nd4 629 19 eliminated eliminate VBD cord-009571-mygj2nd4 629 20 the the DT cord-009571-mygj2nd4 629 21 seroreactivity seroreactivity NN cord-009571-mygj2nd4 629 22 with with IN cord-009571-mygj2nd4 629 23 all all DT cord-009571-mygj2nd4 629 24 B b NN cord-009571-mygj2nd4 629 25 - - HYPH cord-009571-mygj2nd4 629 26 cell cell NN cord-009571-mygj2nd4 629 27 lines line NNS cord-009571-mygj2nd4 629 28 having have VBG cord-009571-mygj2nd4 629 29 any any DT cord-009571-mygj2nd4 629 30 of of IN cord-009571-mygj2nd4 629 31 these these DT cord-009571-mygj2nd4 629 32 three three CD cord-009571-mygj2nd4 629 33 de de NNS cord-009571-mygj2nd4 629 34 - - HYPH cord-009571-mygj2nd4 629 35 terminants terminant NNS cord-009571-mygj2nd4 629 36 , , , cord-009571-mygj2nd4 629 37 thus thus RB cord-009571-mygj2nd4 629 38 demonstrating demonstrate VBG cord-009571-mygj2nd4 629 39 that that IN cord-009571-mygj2nd4 629 40 the the DT cord-009571-mygj2nd4 629 41 alloantisera alloantisera NNP cord-009571-mygj2nd4 629 42 react react VBP cord-009571-mygj2nd4 629 43 with with IN cord-009571-mygj2nd4 629 44 a a DT cord-009571-mygj2nd4 629 45 B b NN cord-009571-mygj2nd4 629 46 - - HYPH cord-009571-mygj2nd4 629 47 cell cell NN cord-009571-mygj2nd4 629 48 antigen antigen NN cord-009571-mygj2nd4 629 49 common common JJ cord-009571-mygj2nd4 629 50 to to IN cord-009571-mygj2nd4 629 51 cells cell NNS cord-009571-mygj2nd4 629 52 with with IN cord-009571-mygj2nd4 629 53 either either DT cord-009571-mygj2nd4 629 54 of of IN cord-009571-mygj2nd4 629 55 the the DT cord-009571-mygj2nd4 629 56 three three CD cord-009571-mygj2nd4 629 57 MLC MLC NNP cord-009571-mygj2nd4 629 58 specificities specificity NNS cord-009571-mygj2nd4 629 59 . . . cord-009571-mygj2nd4 630 1 MLC MLC NNP cord-009571-mygj2nd4 630 2 testing testing NN cord-009571-mygj2nd4 630 3 of of IN cord-009571-mygj2nd4 630 4 the the DT cord-009571-mygj2nd4 630 5 RA RA NNP cord-009571-mygj2nd4 630 6 patients patient NNS cord-009571-mygj2nd4 630 7 with with IN cord-009571-mygj2nd4 630 8 a a DT cord-009571-mygj2nd4 630 9 panel panel NN cord-009571-mygj2nd4 630 10 of of IN cord-009571-mygj2nd4 630 11 normal normal JJ cord-009571-mygj2nd4 630 12 homozygous homozygous JJ cord-009571-mygj2nd4 630 13 cells cell NNS cord-009571-mygj2nd4 630 14 defined define VBN cord-009571-mygj2nd4 630 15 in in IN cord-009571-mygj2nd4 630 16 the the DT cord-009571-mygj2nd4 630 17 Seventh Seventh NNP cord-009571-mygj2nd4 630 18 International International NNP cord-009571-mygj2nd4 630 19 Histocompatibility Histocompatibility NNP cord-009571-mygj2nd4 630 20 Workshop Workshop NNP cord-009571-mygj2nd4 630 21 revealed reveal VBD cord-009571-mygj2nd4 630 22 an an DT cord-009571-mygj2nd4 630 23 increase increase NN cord-009571-mygj2nd4 630 24 in in IN cord-009571-mygj2nd4 630 25 the the DT cord-009571-mygj2nd4 630 26 frequencies frequency NNS cord-009571-mygj2nd4 630 27 of of IN cord-009571-mygj2nd4 630 28 HLA HLA NNP cord-009571-mygj2nd4 630 29 - - HYPH cord-009571-mygj2nd4 630 30 Dw4 dw4 NN cord-009571-mygj2nd4 630 31 and and CC cord-009571-mygj2nd4 630 32 DwlO DwlO NNP cord-009571-mygj2nd4 630 33 as as IN cord-009571-mygj2nd4 630 34 compared compare VBN cord-009571-mygj2nd4 630 35 to to IN cord-009571-mygj2nd4 630 36 controls control NNS cord-009571-mygj2nd4 630 37 ( ( -LRB- cord-009571-mygj2nd4 630 38 26 26 CD cord-009571-mygj2nd4 630 39 % % NN cord-009571-mygj2nd4 630 40 versus versus IN cord-009571-mygj2nd4 630 41 14.6 14.6 CD cord-009571-mygj2nd4 630 42 % % NN cord-009571-mygj2nd4 630 43 and and CC cord-009571-mygj2nd4 630 44 13 13 CD cord-009571-mygj2nd4 630 45 % % NN cord-009571-mygj2nd4 630 46 versus versus IN cord-009571-mygj2nd4 630 47 6.9 6.9 CD cord-009571-mygj2nd4 630 48 % % NN cord-009571-mygj2nd4 630 49 , , , cord-009571-mygj2nd4 630 50 respectively respectively RB cord-009571-mygj2nd4 630 51 ) ) -RRB- cord-009571-mygj2nd4 630 52 , , , cord-009571-mygj2nd4 630 53 while while IN cord-009571-mygj2nd4 630 54 the the DT cord-009571-mygj2nd4 630 55 frequency frequency NN cord-009571-mygj2nd4 630 56 of of IN cord-009571-mygj2nd4 630 57 HLA HLA NNP cord-009571-mygj2nd4 630 58 - - HYPH cord-009571-mygj2nd4 630 59 Dw7 Dw7 NNP cord-009571-mygj2nd4 630 60 was be VBD cord-009571-mygj2nd4 630 61 not not RB cord-009571-mygj2nd4 630 62 significantly significantly RB cord-009571-mygj2nd4 630 63 different different JJ cord-009571-mygj2nd4 630 64 ( ( -LRB- cord-009571-mygj2nd4 630 65 23 23 CD cord-009571-mygj2nd4 630 66 % % NN cord-009571-mygj2nd4 630 67 versus versus IN cord-009571-mygj2nd4 630 68 18.6 18.6 CD cord-009571-mygj2nd4 630 69 % % NN cord-009571-mygj2nd4 630 70 ) ) -RRB- cord-009571-mygj2nd4 630 71 . . . cord-009571-mygj2nd4 631 1 The the DT cord-009571-mygj2nd4 631 2 individuals individual NNS cord-009571-mygj2nd4 631 3 who who WP cord-009571-mygj2nd4 631 4 were be VBD cord-009571-mygj2nd4 631 5 negative negative JJ cord-009571-mygj2nd4 631 6 for for IN cord-009571-mygj2nd4 631 7 the the DT cord-009571-mygj2nd4 631 8 HLA HLA NNP cord-009571-mygj2nd4 631 9 - - HYPH cord-009571-mygj2nd4 631 10 D D NNP cord-009571-mygj2nd4 631 11 alleles allele NNS cord-009571-mygj2nd4 631 12 Dw4 dw4 NN cord-009571-mygj2nd4 631 13 , , , cord-009571-mygj2nd4 631 14 Dw7 dw7 CD cord-009571-mygj2nd4 631 15 , , , cord-009571-mygj2nd4 631 16 and and CC cord-009571-mygj2nd4 631 17 DwlO DwlO NNP cord-009571-mygj2nd4 631 18 by by IN cord-009571-mygj2nd4 631 19 conventional conventional JJ cord-009571-mygj2nd4 631 20 MLC MLC NNP cord-009571-mygj2nd4 631 21 testing testing NN cord-009571-mygj2nd4 631 22 yet yet RB cord-009571-mygj2nd4 631 23 positive positive JJ cord-009571-mygj2nd4 631 24 for for IN cord-009571-mygj2nd4 631 25 the the DT cord-009571-mygj2nd4 631 26 shared share VBN cord-009571-mygj2nd4 631 27 B b NN cord-009571-mygj2nd4 631 28 - - HYPH cord-009571-mygj2nd4 631 29 cell cell NN cord-009571-mygj2nd4 631 30 alloantigenic alloantigenic JJ cord-009571-mygj2nd4 631 31 specificity specificity NN cord-009571-mygj2nd4 631 32 were be VBD cord-009571-mygj2nd4 631 33 of of IN cord-009571-mygj2nd4 631 34 particular particular JJ cord-009571-mygj2nd4 631 35 interest interest NN cord-009571-mygj2nd4 631 36 . . . cord-009571-mygj2nd4 632 1 The the DT cord-009571-mygj2nd4 632 2 results result NNS cord-009571-mygj2nd4 632 3 indicate indicate VBP cord-009571-mygj2nd4 632 4 that that IN cord-009571-mygj2nd4 632 5 a a DT cord-009571-mygj2nd4 632 6 shared share VBN cord-009571-mygj2nd4 632 7 antigenic antigenic JJ cord-009571-mygj2nd4 632 8 specificity specificity NN cord-009571-mygj2nd4 632 9 exists exist VBZ cord-009571-mygj2nd4 632 10 among among IN cord-009571-mygj2nd4 632 11 alleles allele NNS cord-009571-mygj2nd4 632 12 of of IN cord-009571-mygj2nd4 632 13 B b NN cord-009571-mygj2nd4 632 14 - - HYPH cord-009571-mygj2nd4 632 15 cell cell NN cord-009571-mygj2nd4 632 16 alloantigens alloantigen NNS cord-009571-mygj2nd4 632 17 that that WDT cord-009571-mygj2nd4 632 18 is is RB cord-009571-mygj2nd4 632 19 , , , cord-009571-mygj2nd4 632 20 in in IN cord-009571-mygj2nd4 632 21 turn turn NN cord-009571-mygj2nd4 632 22 , , , cord-009571-mygj2nd4 632 23 partially partially RB cord-009571-mygj2nd4 632 24 related relate VBN cord-009571-mygj2nd4 632 25 to to IN cord-009571-mygj2nd4 632 26 particular particular JJ cord-009571-mygj2nd4 632 27 MLC MLC NNP cord-009571-mygj2nd4 632 28 alleles allele NNS cord-009571-mygj2nd4 632 29 . . . cord-009571-mygj2nd4 633 1 Thus thus RB cord-009571-mygj2nd4 633 2 susceptibility susceptibility NN cord-009571-mygj2nd4 633 3 to to IN cord-009571-mygj2nd4 633 4 RA RA NNP cord-009571-mygj2nd4 633 5 may may MD cord-009571-mygj2nd4 633 6 be be VB cord-009571-mygj2nd4 633 7 a a DT cord-009571-mygj2nd4 633 8 function function NN cord-009571-mygj2nd4 633 9 of of IN cord-009571-mygj2nd4 633 10 the the DT cord-009571-mygj2nd4 633 11 inheritance inheritance NN cord-009571-mygj2nd4 633 12 of of IN cord-009571-mygj2nd4 633 13 the the DT cord-009571-mygj2nd4 633 14 molecules molecule NNS cord-009571-mygj2nd4 633 15 bearing bear VBG cord-009571-mygj2nd4 633 16 this this DT cord-009571-mygj2nd4 633 17 antigenic antigenic JJ cord-009571-mygj2nd4 633 18 specificity specificity NN cord-009571-mygj2nd4 633 19 . . . cord-009571-mygj2nd4 634 1 Activation activation NN cord-009571-mygj2nd4 634 2 of of IN cord-009571-mygj2nd4 634 3 mediator mediator NN cord-009571-mygj2nd4 634 4 cells cell NNS cord-009571-mygj2nd4 634 5 such such JJ cord-009571-mygj2nd4 634 6 as as IN cord-009571-mygj2nd4 634 7 platelets platelet NNS cord-009571-mygj2nd4 634 8 and and CC cord-009571-mygj2nd4 634 9 neutrophils neutrophil NNS cord-009571-mygj2nd4 634 10 plays play VBZ cord-009571-mygj2nd4 634 11 an an DT cord-009571-mygj2nd4 634 12 important important JJ cord-009571-mygj2nd4 634 13 role role NN cord-009571-mygj2nd4 634 14 in in IN cord-009571-mygj2nd4 634 15 the the DT cord-009571-mygj2nd4 634 16 pathogenesis pathogenesis NN cord-009571-mygj2nd4 634 17 of of IN cord-009571-mygj2nd4 634 18 gout gout NN cord-009571-mygj2nd4 634 19 . . . cord-009571-mygj2nd4 635 1 Monosodium monosodium NN cord-009571-mygj2nd4 635 2 urate urate NN cord-009571-mygj2nd4 635 3 crystals crystal NNS cord-009571-mygj2nd4 635 4 ( ( -LRB- cord-009571-mygj2nd4 635 5 MSU MSU NNP cord-009571-mygj2nd4 635 6 ) ) -RRB- cord-009571-mygj2nd4 635 7 , , , cord-009571-mygj2nd4 635 8 the the DT cord-009571-mygj2nd4 635 9 probable probable JJ cord-009571-mygj2nd4 635 10 initiating initiate VBG cord-009571-mygj2nd4 635 11 agents agent NNS cord-009571-mygj2nd4 635 12 of of IN cord-009571-mygj2nd4 635 13 gouty gouty JJ cord-009571-mygj2nd4 635 14 inflammation inflammation NN cord-009571-mygj2nd4 635 15 , , , cord-009571-mygj2nd4 635 16 have have VBP cord-009571-mygj2nd4 635 17 been be VBN cord-009571-mygj2nd4 635 18 shown show VBN cord-009571-mygj2nd4 635 19 to to TO cord-009571-mygj2nd4 635 20 stimulate stimulate VB cord-009571-mygj2nd4 635 21 suspensions suspension NNS cord-009571-mygj2nd4 635 22 of of IN cord-009571-mygj2nd4 635 23 washed washed JJ cord-009571-mygj2nd4 635 24 platelets platelet NNS cord-009571-mygj2nd4 635 25 or or CC cord-009571-mygj2nd4 635 26 neutrophils neutrophil NNS cord-009571-mygj2nd4 635 27 . . . cord-009571-mygj2nd4 636 1 When when WRB cord-009571-mygj2nd4 636 2 MSU MSU NNP cord-009571-mygj2nd4 636 3 crystals crystal NNS cord-009571-mygj2nd4 636 4 are be VBP cord-009571-mygj2nd4 636 5 coated coat VBN cord-009571-mygj2nd4 636 6 with with IN cord-009571-mygj2nd4 636 7 IgG IgG NNP cord-009571-mygj2nd4 636 8 ( ( -LRB- cord-009571-mygj2nd4 636 9 as as IN cord-009571-mygj2nd4 636 10 occurs occur NNS cord-009571-mygj2nd4 636 11 in in IN cord-009571-mygj2nd4 636 12 plasma plasma NN cord-009571-mygj2nd4 636 13 ) ) -RRB- cord-009571-mygj2nd4 636 14 , , , cord-009571-mygj2nd4 636 15 stimulation stimulation NN cord-009571-mygj2nd4 636 16 is be VBZ cord-009571-mygj2nd4 636 17 markedly markedly RB cord-009571-mygj2nd4 636 18 enhanced enhance VBN cord-009571-mygj2nd4 636 19 . . . cord-009571-mygj2nd4 637 1 These these DT cord-009571-mygj2nd4 637 2 studies study NNS cord-009571-mygj2nd4 637 3 , , , cord-009571-mygj2nd4 637 4 using use VBG cord-009571-mygj2nd4 637 5 MSU MSU NNP cord-009571-mygj2nd4 637 6 induced induce VBD cord-009571-mygj2nd4 637 7 human human JJ cord-009571-mygj2nd4 637 8 platelet platelet NN cord-009571-mygj2nd4 637 9 serotonin serotonin NN cord-009571-mygj2nd4 637 10 secretion secretion NN cord-009571-mygj2nd4 637 11 as as IN cord-009571-mygj2nd4 637 12 a a DT cord-009571-mygj2nd4 637 13 model model NN cord-009571-mygj2nd4 637 14 , , , cord-009571-mygj2nd4 637 15 examined examine VBD cord-009571-mygj2nd4 637 16 the the DT cord-009571-mygj2nd4 637 17 nature nature NN cord-009571-mygj2nd4 637 18 of of IN cord-009571-mygj2nd4 637 19 cellular cellular JJ cord-009571-mygj2nd4 637 20 recognition recognition NN cord-009571-mygj2nd4 637 21 mechanisms mechanism NNS cord-009571-mygj2nd4 637 22 for for IN cord-009571-mygj2nd4 637 23 the the DT cord-009571-mygj2nd4 637 24 IgG IgG NNP cord-009571-mygj2nd4 637 25 - - HYPH cord-009571-mygj2nd4 637 26 coated coat VBN cord-009571-mygj2nd4 637 27 MSU MSU NNP cord-009571-mygj2nd4 637 28 crystal crystal NN cord-009571-mygj2nd4 637 29 and and CC cord-009571-mygj2nd4 637 30 the the DT cord-009571-mygj2nd4 637 31 uncoated uncoated JJ cord-009571-mygj2nd4 637 32 crystal crystal NN cord-009571-mygj2nd4 637 33 . . . cord-009571-mygj2nd4 638 1 F(ab')2 f(ab')2 CD cord-009571-mygj2nd4 638 2 fragments fragment NNS cord-009571-mygj2nd4 638 3 of of IN cord-009571-mygj2nd4 638 4 specific specific JJ cord-009571-mygj2nd4 638 5 anti anti AFX cord-009571-mygj2nd4 638 6 Fc Fc NNP cord-009571-mygj2nd4 638 7 antibody antibody NN cord-009571-mygj2nd4 638 8 blocked block VBD cord-009571-mygj2nd4 638 9 and and CC cord-009571-mygj2nd4 638 10 the the DT cord-009571-mygj2nd4 638 11 lipopolysaccharide lipopolysaccharide NN cord-009571-mygj2nd4 638 12 of of IN cord-009571-mygj2nd4 638 13 S S NNP cord-009571-mygj2nd4 638 14 minnesota minnesota NNP cord-009571-mygj2nd4 638 15 R595 R595 NNP cord-009571-mygj2nd4 638 16 enhanced enhance VBD cord-009571-mygj2nd4 638 17 human human JJ cord-009571-mygj2nd4 638 18 platelet platelet NN cord-009571-mygj2nd4 638 19 secretion secretion NN cord-009571-mygj2nd4 638 20 induced induce VBN cord-009571-mygj2nd4 638 21 by by IN cord-009571-mygj2nd4 638 22 IgG igg NN cord-009571-mygj2nd4 638 23 - - HYPH cord-009571-mygj2nd4 638 24 coated coat VBN cord-009571-mygj2nd4 638 25 urate urate NN cord-009571-mygj2nd4 638 26 crystals crystal NNS cord-009571-mygj2nd4 638 27 . . . cord-009571-mygj2nd4 639 1 These these DT cord-009571-mygj2nd4 639 2 agents agent NNS cord-009571-mygj2nd4 639 3 had have VBD cord-009571-mygj2nd4 639 4 little little JJ cord-009571-mygj2nd4 639 5 effect effect NN cord-009571-mygj2nd4 639 6 on on IN cord-009571-mygj2nd4 639 7 stimulation stimulation NN cord-009571-mygj2nd4 639 8 by by IN cord-009571-mygj2nd4 639 9 uncoated uncoated JJ cord-009571-mygj2nd4 639 10 crystals crystal NNS cord-009571-mygj2nd4 639 11 . . . cord-009571-mygj2nd4 640 1 This this DT cord-009571-mygj2nd4 640 2 indicated indicate VBD cord-009571-mygj2nd4 640 3 that that IN cord-009571-mygj2nd4 640 4 urate urate NN cord-009571-mygj2nd4 640 5 crystals crystal NNS cord-009571-mygj2nd4 640 6 stimulate stimulate VBP cord-009571-mygj2nd4 640 7 platelets platelet NNS cord-009571-mygj2nd4 640 8 independently independently RB cord-009571-mygj2nd4 640 9 of of IN cord-009571-mygj2nd4 640 10 fluid fluid JJ cord-009571-mygj2nd4 640 11 phase phase NN cord-009571-mygj2nd4 641 1 IgG. IgG. NNP cord-009571-mygj2nd4 641 2 Urate Urate NNP cord-009571-mygj2nd4 641 3 crystals crystal NNS cord-009571-mygj2nd4 641 4 directly directly RB cord-009571-mygj2nd4 641 5 stimulated stimulate VBD cord-009571-mygj2nd4 641 6 suspensions suspension NNS cord-009571-mygj2nd4 641 7 of of IN cord-009571-mygj2nd4 641 8 washed wash VBN cord-009571-mygj2nd4 641 9 rabbit rabbit NN cord-009571-mygj2nd4 641 10 platelets platelet NNS cord-009571-mygj2nd4 641 11 which which WDT cord-009571-mygj2nd4 641 12 lack lack VBP cord-009571-mygj2nd4 641 13 Fc Fc NNP cord-009571-mygj2nd4 641 14 receptors receptor NNS cord-009571-mygj2nd4 641 15 . . . cord-009571-mygj2nd4 642 1 In in IN cord-009571-mygj2nd4 642 2 contrast contrast NN cord-009571-mygj2nd4 642 3 to to IN cord-009571-mygj2nd4 642 4 human human JJ cord-009571-mygj2nd4 642 5 cells cell NNS cord-009571-mygj2nd4 642 6 , , , cord-009571-mygj2nd4 642 7 stimulation stimulation NN cord-009571-mygj2nd4 642 8 was be VBD cord-009571-mygj2nd4 642 9 blocked block VBN cord-009571-mygj2nd4 642 10 by by IN cord-009571-mygj2nd4 643 1 IgG. IgG. NNP cord-009571-mygj2nd4 644 1 This this DT cord-009571-mygj2nd4 644 2 again again RB cord-009571-mygj2nd4 644 3 demonstrated demonstrate VBD cord-009571-mygj2nd4 644 4 IgG igg NN cord-009571-mygj2nd4 644 5 - - HYPH cord-009571-mygj2nd4 644 6 independent independent JJ cord-009571-mygj2nd4 644 7 cell cell NN cord-009571-mygj2nd4 644 8 stimulation stimulation NN cord-009571-mygj2nd4 644 9 by by IN cord-009571-mygj2nd4 644 10 urate urate NN cord-009571-mygj2nd4 644 11 crystals crystal NNS cord-009571-mygj2nd4 644 12 . . . cord-009571-mygj2nd4 645 1 Calcium calcium NN cord-009571-mygj2nd4 645 2 pyrophosphate pyrophosphate NN cord-009571-mygj2nd4 645 3 dihydrate dihydrate NN cord-009571-mygj2nd4 645 4 crystals crystal NNS cord-009571-mygj2nd4 645 5 could could MD cord-009571-mygj2nd4 645 6 trigger trigger VB cord-009571-mygj2nd4 645 7 human human JJ cord-009571-mygj2nd4 645 8 platelet platelet NN cord-009571-mygj2nd4 645 9 secretion secretion NN cord-009571-mygj2nd4 645 10 only only RB cord-009571-mygj2nd4 645 11 when when WRB cord-009571-mygj2nd4 645 12 coated coat VBN cord-009571-mygj2nd4 645 13 with with IN cord-009571-mygj2nd4 646 1 IgG. IgG. NNP cord-009571-mygj2nd4 647 1 This this DT cord-009571-mygj2nd4 647 2 suggests suggest VBZ cord-009571-mygj2nd4 647 3 that that IN cord-009571-mygj2nd4 647 4 when when WRB cord-009571-mygj2nd4 647 5 crystals crystal NNS cord-009571-mygj2nd4 647 6 were be VBD cord-009571-mygj2nd4 647 7 coated coat VBN cord-009571-mygj2nd4 647 8 with with IN cord-009571-mygj2nd4 647 9 IgG IgG NNP cord-009571-mygj2nd4 647 10 , , , cord-009571-mygj2nd4 647 11 the the DT cord-009571-mygj2nd4 647 12 surfacebound surfacebound NNP cord-009571-mygj2nd4 647 13 IgG IgG NNP cord-009571-mygj2nd4 647 14 alone alone RB cord-009571-mygj2nd4 647 15 may may MD cord-009571-mygj2nd4 647 16 be be VB cord-009571-mygj2nd4 647 17 the the DT cord-009571-mygj2nd4 647 18 stimulus stimulus NN cord-009571-mygj2nd4 647 19 to to IN cord-009571-mygj2nd4 647 20 the the DT cord-009571-mygj2nd4 647 21 cell cell NN cord-009571-mygj2nd4 647 22 . . . cord-009571-mygj2nd4 648 1 This this DT cord-009571-mygj2nd4 648 2 was be VBD cord-009571-mygj2nd4 648 3 confirmed confirm VBN cord-009571-mygj2nd4 648 4 by by IN cord-009571-mygj2nd4 648 5 the the DT cord-009571-mygj2nd4 648 6 finding finding NN cord-009571-mygj2nd4 648 7 that that IN cord-009571-mygj2nd4 648 8 polyvinyl polyvinyl NN cord-009571-mygj2nd4 648 9 pyridine pyridine NN cord-009571-mygj2nd4 648 10 - - HYPH cord-009571-mygj2nd4 648 11 N n NN cord-009571-mygj2nd4 648 12 - - HYPH cord-009571-mygj2nd4 648 13 oxide oxide NN cord-009571-mygj2nd4 648 14 , , , cord-009571-mygj2nd4 648 15 a a DT cord-009571-mygj2nd4 648 16 hydrogen hydrogen NN cord-009571-mygj2nd4 648 17 acceptor acceptor NN cord-009571-mygj2nd4 648 18 , , , cord-009571-mygj2nd4 648 19 blocked block VBD cord-009571-mygj2nd4 648 20 human human JJ cord-009571-mygj2nd4 648 21 platelet platelet NN cord-009571-mygj2nd4 648 22 stimulation stimulation NN cord-009571-mygj2nd4 648 23 by by IN cord-009571-mygj2nd4 648 24 uncoated uncoated JJ cord-009571-mygj2nd4 648 25 but but CC cord-009571-mygj2nd4 648 26 not not RB cord-009571-mygj2nd4 648 27 IgG igg NN cord-009571-mygj2nd4 648 28 - - HYPH cord-009571-mygj2nd4 648 29 coated coat VBN cord-009571-mygj2nd4 648 30 urate urate NN cord-009571-mygj2nd4 648 31 crystals crystal NNS cord-009571-mygj2nd4 648 32 . . . cord-009571-mygj2nd4 649 1 In in IN cord-009571-mygj2nd4 649 2 contrast contrast NN cord-009571-mygj2nd4 649 3 to to IN cord-009571-mygj2nd4 649 4 IgG IgG NNP cord-009571-mygj2nd4 649 5 , , , cord-009571-mygj2nd4 649 6 F(ab')2 f(ab')2 CD cord-009571-mygj2nd4 649 7 fragments fragment NNS cord-009571-mygj2nd4 649 8 , , , cord-009571-mygj2nd4 649 9 IgM IgM NNP cord-009571-mygj2nd4 649 10 , , , cord-009571-mygj2nd4 649 11 or or CC cord-009571-mygj2nd4 649 12 IgA IgA NNP cord-009571-mygj2nd4 649 13 did do VBD cord-009571-mygj2nd4 649 14 not not RB cord-009571-mygj2nd4 649 15 enhance enhance VB cord-009571-mygj2nd4 649 16 human human JJ cord-009571-mygj2nd4 649 17 platelet platelet NN cord-009571-mygj2nd4 649 18 stimulation stimulation NN cord-009571-mygj2nd4 649 19 by by IN cord-009571-mygj2nd4 649 20 urate urate NN cord-009571-mygj2nd4 649 21 crystals crystal NNS cord-009571-mygj2nd4 649 22 . . . cord-009571-mygj2nd4 650 1 This this DT cord-009571-mygj2nd4 650 2 indicates indicate VBZ cord-009571-mygj2nd4 650 3 that that IN cord-009571-mygj2nd4 650 4 the the DT cord-009571-mygj2nd4 650 5 effect effect NN cord-009571-mygj2nd4 650 6 of of IN cord-009571-mygj2nd4 650 7 IgG IgG NNP cord-009571-mygj2nd4 650 8 on on IN cord-009571-mygj2nd4 650 9 urate urate NNP cord-009571-mygj2nd4 650 10 crystal crystal NN cord-009571-mygj2nd4 650 11 stimulation stimulation NN cord-009571-mygj2nd4 650 12 of of IN cord-009571-mygj2nd4 650 13 platelets platelet NNS cord-009571-mygj2nd4 650 14 depends depend VBZ cord-009571-mygj2nd4 650 15 on on IN cord-009571-mygj2nd4 650 16 the the DT cord-009571-mygj2nd4 650 17 Fc Fc NNP cord-009571-mygj2nd4 650 18 region region NN cord-009571-mygj2nd4 650 19 of of IN cord-009571-mygj2nd4 650 20 IgG. IgG. NNP cord-009571-mygj2nd4 651 1 These these DT cord-009571-mygj2nd4 651 2 data datum NNS cord-009571-mygj2nd4 651 3 demonstrate demonstrate VBP cord-009571-mygj2nd4 651 4 that that IN cord-009571-mygj2nd4 651 5 urate urate NN cord-009571-mygj2nd4 651 6 crystals crystal NNS cord-009571-mygj2nd4 651 7 ( ( -LRB- cord-009571-mygj2nd4 651 8 and and CC cord-009571-mygj2nd4 651 9 potentially potentially RB cord-009571-mygj2nd4 651 10 other other JJ cord-009571-mygj2nd4 651 11 surfaces surface NNS cord-009571-mygj2nd4 651 12 or or CC cord-009571-mygj2nd4 651 13 particles particle NNS cord-009571-mygj2nd4 651 14 ) ) -RRB- cord-009571-mygj2nd4 651 15 can can MD cord-009571-mygj2nd4 651 16 stimulate stimulate VB cord-009571-mygj2nd4 651 17 a a DT cord-009571-mygj2nd4 651 18 mediator mediator NN cord-009571-mygj2nd4 651 19 cell cell NN cord-009571-mygj2nd4 651 20 by by IN cord-009571-mygj2nd4 651 21 at at RB cord-009571-mygj2nd4 651 22 least least RBS cord-009571-mygj2nd4 651 23 two two CD cord-009571-mygj2nd4 651 24 mechanisms mechanism NNS cord-009571-mygj2nd4 651 25 : : : cord-009571-mygj2nd4 651 26 by by IN cord-009571-mygj2nd4 651 27 direct direct JJ cord-009571-mygj2nd4 651 28 stimulation stimulation NN cord-009571-mygj2nd4 651 29 without without IN cord-009571-mygj2nd4 651 30 the the DT cord-009571-mygj2nd4 651 31 mediation mediation NN cord-009571-mygj2nd4 651 32 of of IN cord-009571-mygj2nd4 651 33 absorbed absorb VBN cord-009571-mygj2nd4 651 34 IgG igg NN cord-009571-mygj2nd4 651 35 or or CC cord-009571-mygj2nd4 651 36 when when WRB cord-009571-mygj2nd4 651 37 coated coat VBN cord-009571-mygj2nd4 651 38 with with IN cord-009571-mygj2nd4 651 39 IgG IgG NNP cord-009571-mygj2nd4 651 40 , , , cord-009571-mygj2nd4 651 41 by by IN cord-009571-mygj2nd4 651 42 triggering trigger VBG cord-009571-mygj2nd4 651 43 the the DT cord-009571-mygj2nd4 651 44 cell cell NN cord-009571-mygj2nd4 651 45 via via IN cord-009571-mygj2nd4 651 46 Fc Fc NNP cord-009571-mygj2nd4 651 47 receptors receptor NNS cord-009571-mygj2nd4 651 48 . . . cord-009571-mygj2nd4 652 1 The the DT cord-009571-mygj2nd4 652 2 correlation correlation NN cord-009571-mygj2nd4 652 3 of of IN cord-009571-mygj2nd4 652 4 serologic serologic JJ cord-009571-mygj2nd4 652 5 abnormalities abnormality NNS cord-009571-mygj2nd4 652 6 , , , cord-009571-mygj2nd4 652 7 especially especially RB cord-009571-mygj2nd4 652 8 low low JJ cord-009571-mygj2nd4 652 9 serum serum NN cord-009571-mygj2nd4 652 10 complement complement NN cord-009571-mygj2nd4 652 11 and and CC cord-009571-mygj2nd4 652 12 high high JJ cord-009571-mygj2nd4 652 13 levels level NNS cord-009571-mygj2nd4 652 14 of of IN cord-009571-mygj2nd4 652 15 anti anti JJ cord-009571-mygj2nd4 652 16 - - JJ cord-009571-mygj2nd4 652 17 DNA dna JJ cord-009571-mygj2nd4 652 18 antibody antibody NN cord-009571-mygj2nd4 652 19 , , , cord-009571-mygj2nd4 652 20 with with IN cord-009571-mygj2nd4 652 21 disease disease NN cord-009571-mygj2nd4 652 22 activity activity NN cord-009571-mygj2nd4 652 23 has have VBZ cord-009571-mygj2nd4 652 24 been be VBN cord-009571-mygj2nd4 652 25 established establish VBN cord-009571-mygj2nd4 652 26 in in IN cord-009571-mygj2nd4 652 27 SLE SLE NNP cord-009571-mygj2nd4 652 28 . . . cord-009571-mygj2nd4 653 1 The the DT cord-009571-mygj2nd4 653 2 significance significance NN cord-009571-mygj2nd4 653 3 of of IN cord-009571-mygj2nd4 653 4 abnormal abnormal JJ cord-009571-mygj2nd4 653 5 serologic serologic JJ cord-009571-mygj2nd4 653 6 tests test NNS cord-009571-mygj2nd4 653 7 in in IN cord-009571-mygj2nd4 653 8 the the DT cord-009571-mygj2nd4 653 9 absence absence NN cord-009571-mygj2nd4 653 10 of of IN cord-009571-mygj2nd4 653 11 active active JJ cord-009571-mygj2nd4 653 12 clinical clinical JJ cord-009571-mygj2nd4 653 13 disease disease NN cord-009571-mygj2nd4 653 14 is be VBZ cord-009571-mygj2nd4 653 15 still still RB cord-009571-mygj2nd4 653 16 unclear unclear JJ cord-009571-mygj2nd4 653 17 . . . cord-009571-mygj2nd4 654 1 This this DT cord-009571-mygj2nd4 654 2 report report NN cord-009571-mygj2nd4 654 3 describes describe VBZ cord-009571-mygj2nd4 654 4 a a DT cord-009571-mygj2nd4 654 5 group group NN cord-009571-mygj2nd4 654 6 of of IN cord-009571-mygj2nd4 654 7 14 14 CD cord-009571-mygj2nd4 654 8 patients patient NNS cord-009571-mygj2nd4 654 9 seen see VBN cord-009571-mygj2nd4 654 10 in in IN cord-009571-mygj2nd4 654 11 the the DT cord-009571-mygj2nd4 654 12 course course NN cord-009571-mygj2nd4 654 13 of of IN cord-009571-mygj2nd4 654 14 a a DT cord-009571-mygj2nd4 654 15 prospective prospective JJ cord-009571-mygj2nd4 654 16 study study NN cord-009571-mygj2nd4 654 17 of of IN cord-009571-mygj2nd4 654 18 SLE SLE NNP cord-009571-mygj2nd4 654 19 in in IN cord-009571-mygj2nd4 654 20 whom whom WP cord-009571-mygj2nd4 654 21 a a DT cord-009571-mygj2nd4 654 22 discordance discordance NN cord-009571-mygj2nd4 654 23 between between IN cord-009571-mygj2nd4 654 24 clinical clinical JJ cord-009571-mygj2nd4 654 25 and and CC cord-009571-mygj2nd4 654 26 serologic serologic NN cord-009571-mygj2nd4 654 27 features feature NNS cord-009571-mygj2nd4 654 28 was be VBD cord-009571-mygj2nd4 654 29 apparent apparent JJ cord-009571-mygj2nd4 654 30 . . . cord-009571-mygj2nd4 655 1 These these DT cord-009571-mygj2nd4 655 2 patients patient NNS cord-009571-mygj2nd4 655 3 had have VBD cord-009571-mygj2nd4 655 4 persistently persistently RB cord-009571-mygj2nd4 655 5 positive positive JJ cord-009571-mygj2nd4 655 6 LE LE NNP cord-009571-mygj2nd4 655 7 preps prep NNS cord-009571-mygj2nd4 655 8 and and CC cord-009571-mygj2nd4 655 9 antinuclear antinuclear JJ cord-009571-mygj2nd4 655 10 antibody antibody NN cord-009571-mygj2nd4 655 11 tests test NNS cord-009571-mygj2nd4 655 12 , , , cord-009571-mygj2nd4 655 13 low low JJ cord-009571-mygj2nd4 655 14 serum serum NN cord-009571-mygj2nd4 655 15 complements complement VBZ cord-009571-mygj2nd4 655 16 , , , cord-009571-mygj2nd4 655 17 and and CC cord-009571-mygj2nd4 655 18 high high JJ cord-009571-mygj2nd4 655 19 levels level NNS cord-009571-mygj2nd4 655 20 of of IN cord-009571-mygj2nd4 655 21 DNA dna NN cord-009571-mygj2nd4 655 22 binding binding NN cord-009571-mygj2nd4 655 23 . . . cord-009571-mygj2nd4 656 1 The the DT cord-009571-mygj2nd4 656 2 mean mean JJ cord-009571-mygj2nd4 656 3 lymphocyte lymphocyte NN cord-009571-mygj2nd4 656 4 response response NN cord-009571-mygj2nd4 656 5 to to IN cord-009571-mygj2nd4 656 6 Con Con NNP cord-009571-mygj2nd4 656 7 A a DT cord-009571-mygj2nd4 656 8 mitogen mitogen NN cord-009571-mygj2nd4 656 9 was be VBD cord-009571-mygj2nd4 656 10 suppressed suppress VBN cord-009571-mygj2nd4 656 11 in in IN cord-009571-mygj2nd4 656 12 these these DT cord-009571-mygj2nd4 656 13 patients patient NNS cord-009571-mygj2nd4 656 14 as as IN cord-009571-mygj2nd4 656 15 compared compare VBN cord-009571-mygj2nd4 656 16 to to IN cord-009571-mygj2nd4 656 17 age age NN cord-009571-mygj2nd4 656 18 and and CC cord-009571-mygj2nd4 656 19 sex sex NN cord-009571-mygj2nd4 656 20 matched match VBN cord-009571-mygj2nd4 656 21 controls control NNS cord-009571-mygj2nd4 656 22 done do VBN cord-009571-mygj2nd4 656 23 on on IN cord-009571-mygj2nd4 656 24 the the DT cord-009571-mygj2nd4 656 25 same same JJ cord-009571-mygj2nd4 656 26 day day NN cord-009571-mygj2nd4 656 27 . . . cord-009571-mygj2nd4 657 1 These these DT cord-009571-mygj2nd4 657 2 patients patient NNS cord-009571-mygj2nd4 657 3 did do VBD cord-009571-mygj2nd4 657 4 not not RB cord-009571-mygj2nd4 657 5 differ differ VB cord-009571-mygj2nd4 657 6 significantly significantly RB cord-009571-mygj2nd4 657 7 from from IN cord-009571-mygj2nd4 657 8 other other JJ cord-009571-mygj2nd4 657 9 patients patient NNS cord-009571-mygj2nd4 657 10 with with IN cord-009571-mygj2nd4 657 11 SLE SLE NNP cord-009571-mygj2nd4 657 12 , , , cord-009571-mygj2nd4 657 13 seen see VBN cord-009571-mygj2nd4 657 14 during during IN cord-009571-mygj2nd4 657 15 the the DT cord-009571-mygj2nd4 657 16 same same JJ cord-009571-mygj2nd4 657 17 period period NN cord-009571-mygj2nd4 657 18 , , , cord-009571-mygj2nd4 657 19 in in IN cord-009571-mygj2nd4 657 20 the the DT cord-009571-mygj2nd4 657 21 frequency frequency NN cord-009571-mygj2nd4 657 22 of of IN cord-009571-mygj2nd4 657 23 skin skin NN cord-009571-mygj2nd4 657 24 manifestations manifestation NNS cord-009571-mygj2nd4 657 25 , , , cord-009571-mygj2nd4 657 26 Raynaud Raynaud NNP cord-009571-mygj2nd4 657 27 's 's POS cord-009571-mygj2nd4 657 28 phenomenon phenomenon NN cord-009571-mygj2nd4 657 29 , , , cord-009571-mygj2nd4 657 30 and and CC cord-009571-mygj2nd4 657 31 arthritis arthritis NN cord-009571-mygj2nd4 657 32 ; ; : cord-009571-mygj2nd4 657 33 they -PRON- PRP cord-009571-mygj2nd4 657 34 showed show VBD cord-009571-mygj2nd4 657 35 trends trend NNS cord-009571-mygj2nd4 657 36 toward toward IN cord-009571-mygj2nd4 657 37 a a DT cord-009571-mygj2nd4 657 38 lower low JJR cord-009571-mygj2nd4 657 39 frequency frequency NN cord-009571-mygj2nd4 657 40 of of IN cord-009571-mygj2nd4 657 41 photosensitivity photosensitivity NN cord-009571-mygj2nd4 657 42 , , , cord-009571-mygj2nd4 657 43 serositis serositis NN cord-009571-mygj2nd4 657 44 , , , cord-009571-mygj2nd4 657 45 mucous mucous JJ cord-009571-mygj2nd4 657 46 membrane membrane NN cord-009571-mygj2nd4 657 47 ulcers ulcer NNS cord-009571-mygj2nd4 657 48 , , , cord-009571-mygj2nd4 657 49 and and CC cord-009571-mygj2nd4 657 50 neu neu NNP cord-009571-mygj2nd4 657 51 - - HYPH cord-009571-mygj2nd4 657 52 ropsychiatric ropsychiatric NNP cord-009571-mygj2nd4 657 53 involvement involvement NN cord-009571-mygj2nd4 657 54 and and CC cord-009571-mygj2nd4 657 55 had have VBD cord-009571-mygj2nd4 657 56 a a DT cord-009571-mygj2nd4 657 57 statistically statistically RB cord-009571-mygj2nd4 657 58 significant significant JJ cord-009571-mygj2nd4 657 59 lower low JJR cord-009571-mygj2nd4 657 60 frequency frequency NN cord-009571-mygj2nd4 657 61 of of IN cord-009571-mygj2nd4 657 62 alopecia alopecia NN cord-009571-mygj2nd4 657 63 and and CC cord-009571-mygj2nd4 657 64 nephritis nephritis NN cord-009571-mygj2nd4 657 65 . . . cord-009571-mygj2nd4 658 1 They -PRON- PRP cord-009571-mygj2nd4 658 2 also also RB cord-009571-mygj2nd4 658 3 resembled resemble VBD cord-009571-mygj2nd4 658 4 the the DT cord-009571-mygj2nd4 658 5 larger large JJR cord-009571-mygj2nd4 658 6 group group NN cord-009571-mygj2nd4 658 7 in in IN cord-009571-mygj2nd4 658 8 the the DT cord-009571-mygj2nd4 658 9 presence presence NN cord-009571-mygj2nd4 658 10 of of IN cord-009571-mygj2nd4 658 11 most most JJS cord-009571-mygj2nd4 658 12 laboratory laboratory NN cord-009571-mygj2nd4 658 13 abnormalities abnormality NNS cord-009571-mygj2nd4 658 14 with with IN cord-009571-mygj2nd4 658 15 only only JJ cord-009571-mygj2nd4 658 16 hypergammaglobulinemia hypergammaglobulinemia NN cord-009571-mygj2nd4 658 17 occurring occur VBG cord-009571-mygj2nd4 658 18 less less RBR cord-009571-mygj2nd4 658 19 frequently frequently RB cord-009571-mygj2nd4 658 20 . . . cord-009571-mygj2nd4 659 1 These these DT cord-009571-mygj2nd4 659 2 patients patient NNS cord-009571-mygj2nd4 659 3 have have VBP cord-009571-mygj2nd4 659 4 been be VBN cord-009571-mygj2nd4 659 5 followed follow VBN cord-009571-mygj2nd4 659 6 untreated untreated JJ cord-009571-mygj2nd4 659 7 for for IN cord-009571-mygj2nd4 659 8 a a DT cord-009571-mygj2nd4 659 9 mean mean NN cord-009571-mygj2nd4 659 10 of of IN cord-009571-mygj2nd4 659 11 4 4 CD cord-009571-mygj2nd4 659 12 % % NN cord-009571-mygj2nd4 659 13 years year NNS cord-009571-mygj2nd4 659 14 without without IN cord-009571-mygj2nd4 659 15 evidence evidence NN cord-009571-mygj2nd4 659 16 of of IN cord-009571-mygj2nd4 659 17 clinical clinical JJ cord-009571-mygj2nd4 659 18 exacerbations exacerbation NNS cord-009571-mygj2nd4 659 19 of of IN cord-009571-mygj2nd4 659 20 disease disease NN cord-009571-mygj2nd4 659 21 . . . cord-009571-mygj2nd4 660 1 Thus thus RB cord-009571-mygj2nd4 660 2 in in IN cord-009571-mygj2nd4 660 3 individual individual JJ cord-009571-mygj2nd4 660 4 patients patient NNS cord-009571-mygj2nd4 660 5 with with IN cord-009571-mygj2nd4 660 6 SLE SLE NNP cord-009571-mygj2nd4 660 7 it -PRON- PRP cord-009571-mygj2nd4 660 8 would would MD cord-009571-mygj2nd4 660 9 seem seem VB cord-009571-mygj2nd4 660 10 advisable advisable JJ cord-009571-mygj2nd4 660 11 to to TO cord-009571-mygj2nd4 660 12 determine determine VB cord-009571-mygj2nd4 660 13 whether whether IN cord-009571-mygj2nd4 660 14 their -PRON- PRP$ cord-009571-mygj2nd4 660 15 clinical clinical JJ cord-009571-mygj2nd4 660 16 course course NN cord-009571-mygj2nd4 660 17 and and CC cord-009571-mygj2nd4 660 18 laboratory laboratory NN cord-009571-mygj2nd4 660 19 abnormalities abnormality NNS cord-009571-mygj2nd4 660 20 are be VBP cord-009571-mygj2nd4 660 21 concordant concordant JJ cord-009571-mygj2nd4 660 22 . . . cord-009571-mygj2nd4 661 1 Some some DT cord-009571-mygj2nd4 661 2 patients patient NNS cord-009571-mygj2nd4 661 3 will will MD cord-009571-mygj2nd4 661 4 illustrate illustrate VB cord-009571-mygj2nd4 661 5 this this DT cord-009571-mygj2nd4 661 6 pattern pattern NN cord-009571-mygj2nd4 661 7 and and CC cord-009571-mygj2nd4 661 8 thus thus RB cord-009571-mygj2nd4 661 9 therapeutic therapeutic JJ cord-009571-mygj2nd4 661 10 manipulation manipulation NN cord-009571-mygj2nd4 661 11 according accord VBG cord-009571-mygj2nd4 661 12 to to IN cord-009571-mygj2nd4 661 13 changes change NNS cord-009571-mygj2nd4 661 14 in in IN cord-009571-mygj2nd4 661 15 laboratory laboratory NN cord-009571-mygj2nd4 661 16 variables variable NNS cord-009571-mygj2nd4 661 17 may may MD cord-009571-mygj2nd4 661 18 be be VB cord-009571-mygj2nd4 661 19 indicated indicate VBN cord-009571-mygj2nd4 661 20 . . . cord-009571-mygj2nd4 662 1 Some some DT cord-009571-mygj2nd4 662 2 patients patient NNS cord-009571-mygj2nd4 662 3 will will MD cord-009571-mygj2nd4 662 4 display display VB cord-009571-mygj2nd4 662 5 clinical clinical JJ cord-009571-mygj2nd4 662 6 - - HYPH cord-009571-mygj2nd4 662 7 laboratory laboratory NN cord-009571-mygj2nd4 662 8 discordance discordance NN cord-009571-mygj2nd4 662 9 and and CC cord-009571-mygj2nd4 662 10 could could MD cord-009571-mygj2nd4 662 11 then then RB cord-009571-mygj2nd4 662 12 be be VB cord-009571-mygj2nd4 662 13 treated treat VBN cord-009571-mygj2nd4 662 14 for for IN cord-009571-mygj2nd4 662 15 clinical clinical JJ cord-009571-mygj2nd4 662 16 exacerbations exacerbation NNS cord-009571-mygj2nd4 662 17 only only RB cord-009571-mygj2nd4 662 18 , , , cord-009571-mygj2nd4 662 19 irrespective irrespective RB cord-009571-mygj2nd4 662 20 of of IN cord-009571-mygj2nd4 662 21 laboratory laboratory NN cord-009571-mygj2nd4 662 22 changes change NNS cord-009571-mygj2nd4 662 23 . . . cord-009571-mygj2nd4 663 1 Followup followup NN cord-009571-mygj2nd4 663 2 in in IN cord-009571-mygj2nd4 663 3 our -PRON- PRP$ cord-009571-mygj2nd4 663 4 14 14 CD cord-009571-mygj2nd4 663 5 patients patient NNS cord-009571-mygj2nd4 663 6 would would MD cord-009571-mygj2nd4 663 7 indicate indicate VB cord-009571-mygj2nd4 663 8 that that IN cord-009571-mygj2nd4 663 9 patients patient NNS cord-009571-mygj2nd4 663 10 with with IN cord-009571-mygj2nd4 663 11 such such JJ cord-009571-mygj2nd4 663 12 humoral humoral JJ cord-009571-mygj2nd4 663 13 and and CC cord-009571-mygj2nd4 663 14 cellular cellular JJ cord-009571-mygj2nd4 663 15 immune immune JJ cord-009571-mygj2nd4 663 16 abnormalities abnormality NNS cord-009571-mygj2nd4 663 17 may may MD cord-009571-mygj2nd4 663 18 safely safely RB cord-009571-mygj2nd4 663 19 be be VB cord-009571-mygj2nd4 663 20 followed follow VBN cord-009571-mygj2nd4 663 21 untreated untreated JJ cord-009571-mygj2nd4 663 22 for for IN cord-009571-mygj2nd4 663 23 prolonged prolonged JJ cord-009571-mygj2nd4 663 24 periods period NNS cord-009571-mygj2nd4 663 25 . . . cord-009571-mygj2nd4 663 26 _SP cord-009571-mygj2nd4 664 1 Independently independently RB cord-009571-mygj2nd4 664 2 and and CC cord-009571-mygj2nd4 664 3 in in IN cord-009571-mygj2nd4 664 4 two two CD cord-009571-mygj2nd4 664 5 separate separate JJ cord-009571-mygj2nd4 664 6 laboratories laboratory NNS cord-009571-mygj2nd4 664 7 , , , cord-009571-mygj2nd4 664 8 cocultivation cocultivation NN cord-009571-mygj2nd4 664 9 techniques technique NNS cord-009571-mygj2nd4 664 10 have have VBP cord-009571-mygj2nd4 664 11 demonstrated demonstrate VBN cord-009571-mygj2nd4 664 12 the the DT cord-009571-mygj2nd4 664 13 presence presence NN cord-009571-mygj2nd4 664 14 of of IN cord-009571-mygj2nd4 664 15 viruslike viruslike JJ cord-009571-mygj2nd4 664 16 particles particle NNS cord-009571-mygj2nd4 664 17 ( ( -LRB- cord-009571-mygj2nd4 664 18 VLPs VLPs NNP cord-009571-mygj2nd4 664 19 ) ) -RRB- cord-009571-mygj2nd4 664 20 in in IN cord-009571-mygj2nd4 664 21 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 664 22 synovial synovial JJ cord-009571-mygj2nd4 664 23 membrane membrane NN cord-009571-mygj2nd4 664 24 cells cell NNS cord-009571-mygj2nd4 664 25 ( ( -LRB- cord-009571-mygj2nd4 664 26 RSC RSC NNP cord-009571-mygj2nd4 664 27 ) ) -RRB- cord-009571-mygj2nd4 664 28 . . . cord-009571-mygj2nd4 665 1 One one CD cord-009571-mygj2nd4 665 2 technique technique NN cord-009571-mygj2nd4 665 3 consisted consist VBD cord-009571-mygj2nd4 665 4 of of IN cord-009571-mygj2nd4 665 5 cocultivation cocultivation NN cord-009571-mygj2nd4 665 6 of of IN cord-009571-mygj2nd4 665 7 long long JJ cord-009571-mygj2nd4 665 8 - - HYPH cord-009571-mygj2nd4 665 9 term term NN cord-009571-mygj2nd4 665 10 RSC RSC NNP cord-009571-mygj2nd4 665 11 cultures culture NNS cord-009571-mygj2nd4 665 12 with with IN cord-009571-mygj2nd4 665 13 human human JJ cord-009571-mygj2nd4 665 14 lung lung NN cord-009571-mygj2nd4 665 15 fibroblasts fibroblast NNS cord-009571-mygj2nd4 665 16 ( ( -LRB- cord-009571-mygj2nd4 665 17 WI WI NNP cord-009571-mygj2nd4 665 18 38 38 CD cord-009571-mygj2nd4 665 19 ) ) -RRB- cord-009571-mygj2nd4 665 20 ; ; : cord-009571-mygj2nd4 665 21 the the DT cord-009571-mygj2nd4 665 22 other other JJ cord-009571-mygj2nd4 665 23 system system NN cord-009571-mygj2nd4 665 24 utilized utilize VBN cord-009571-mygj2nd4 665 25 cocultivation cocultivation NN cord-009571-mygj2nd4 665 26 of of IN cord-009571-mygj2nd4 665 27 freshly freshly RB cord-009571-mygj2nd4 665 28 dissaggregated dissaggregate VBN cord-009571-mygj2nd4 665 29 RSC RSC NNP cord-009571-mygj2nd4 665 30 with with IN cord-009571-mygj2nd4 665 31 fetal fetal JJ cord-009571-mygj2nd4 665 32 rabbit rabbit NN cord-009571-mygj2nd4 665 33 synovialcell synovialcell NNP cord-009571-mygj2nd4 665 34 cultures culture NNS cord-009571-mygj2nd4 665 35 . . . cord-009571-mygj2nd4 666 1 Controls control NNS cord-009571-mygj2nd4 666 2 in in IN cord-009571-mygj2nd4 666 3 both both DT cord-009571-mygj2nd4 666 4 laboratories laboratory NNS cord-009571-mygj2nd4 666 5 consisted consist VBN cord-009571-mygj2nd4 666 6 of of IN cord-009571-mygj2nd4 666 7 similar similar JJ cord-009571-mygj2nd4 666 8 cocultivations cocultivation NNS cord-009571-mygj2nd4 666 9 using use VBG cord-009571-mygj2nd4 666 10 cultures culture NNS cord-009571-mygj2nd4 666 11 derived derive VBN cord-009571-mygj2nd4 666 12 from from IN cord-009571-mygj2nd4 666 13 nonrheumatoid nonrheumatoid NNP cord-009571-mygj2nd4 666 14 membranes membrane NNS cord-009571-mygj2nd4 666 15 . . . cord-009571-mygj2nd4 667 1 All all DT cord-009571-mygj2nd4 667 2 cocultivations cocultivation NNS cord-009571-mygj2nd4 667 3 were be VBD cord-009571-mygj2nd4 667 4 maintained maintain VBN cord-009571-mygj2nd4 667 5 for for IN cord-009571-mygj2nd4 667 6 2 2 CD cord-009571-mygj2nd4 667 7 - - SYM cord-009571-mygj2nd4 667 8 3 3 CD cord-009571-mygj2nd4 667 9 months month NNS cord-009571-mygj2nd4 667 10 without without IN cord-009571-mygj2nd4 667 11 subculture subculture NN cord-009571-mygj2nd4 667 12 , , , cord-009571-mygj2nd4 667 13 during during IN cord-009571-mygj2nd4 667 14 which which WDT cord-009571-mygj2nd4 667 15 time time NN cord-009571-mygj2nd4 667 16 small small JJ cord-009571-mygj2nd4 667 17 foci foci NN cord-009571-mygj2nd4 667 18 of of IN cord-009571-mygj2nd4 667 19 heaped heap VBN cord-009571-mygj2nd4 667 20 - - HYPH cord-009571-mygj2nd4 667 21 up up RP cord-009571-mygj2nd4 667 22 cells cell NNS cord-009571-mygj2nd4 667 23 were be VBD cord-009571-mygj2nd4 667 24 observed observe VBN cord-009571-mygj2nd4 667 25 . . . cord-009571-mygj2nd4 668 1 By by IN cord-009571-mygj2nd4 668 2 electron electron NN cord-009571-mygj2nd4 668 3 microscopy microscopy NNS cord-009571-mygj2nd4 668 4 , , , cord-009571-mygj2nd4 668 5 all all PDT cord-009571-mygj2nd4 668 6 the the DT cord-009571-mygj2nd4 668 7 rheumatoid rheumatoid NN cord-009571-mygj2nd4 668 8 cultures culture NNS cord-009571-mygj2nd4 668 9 ( ( -LRB- cord-009571-mygj2nd4 668 10 15 15 CD cord-009571-mygj2nd4 668 11 ) ) -RRB- cord-009571-mygj2nd4 668 12 but but CC cord-009571-mygj2nd4 668 13 none none NN cord-009571-mygj2nd4 668 14 of of IN cord-009571-mygj2nd4 668 15 the the DT cord-009571-mygj2nd4 668 16 control control NN cord-009571-mygj2nd4 668 17 cultures culture NNS cord-009571-mygj2nd4 668 18 ( ( -LRB- cord-009571-mygj2nd4 668 19 7 7 CD cord-009571-mygj2nd4 668 20 ) ) -RRB- cord-009571-mygj2nd4 668 21 showed show VBD cord-009571-mygj2nd4 668 22 VLPs vlp NNS cord-009571-mygj2nd4 668 23 . . . cord-009571-mygj2nd4 669 1 These these DT cord-009571-mygj2nd4 669 2 appeared appear VBD cord-009571-mygj2nd4 669 3 as as IN cord-009571-mygj2nd4 669 4 spherical spherical JJ cord-009571-mygj2nd4 669 5 bodies body NNS cord-009571-mygj2nd4 669 6 with with IN cord-009571-mygj2nd4 669 7 a a DT cord-009571-mygj2nd4 669 8 spike spike NN cord-009571-mygj2nd4 669 9 - - HYPH cord-009571-mygj2nd4 669 10 like like JJ cord-009571-mygj2nd4 669 11 external external JJ cord-009571-mygj2nd4 669 12 array array NN cord-009571-mygj2nd4 669 13 , , , cord-009571-mygj2nd4 669 14 seen see VBN cord-009571-mygj2nd4 669 15 both both CC cord-009571-mygj2nd4 669 16 in in IN cord-009571-mygj2nd4 669 17 sonicated sonicated JJ cord-009571-mygj2nd4 669 18 negatively negatively RB cord-009571-mygj2nd4 669 19 stained stain VBN cord-009571-mygj2nd4 669 20 ( ( -LRB- cord-009571-mygj2nd4 669 21 PTA PTA NNP cord-009571-mygj2nd4 669 22 ) ) -RRB- cord-009571-mygj2nd4 669 23 preparations preparation NNS cord-009571-mygj2nd4 669 24 , , , cord-009571-mygj2nd4 669 25 and and CC cord-009571-mygj2nd4 669 26 in in IN cord-009571-mygj2nd4 669 27 thin thin JJ cord-009571-mygj2nd4 669 28 sections section NNS cord-009571-mygj2nd4 669 29 of of IN cord-009571-mygj2nd4 669 30 harvested harvest VBN cord-009571-mygj2nd4 669 31 RSC RSC NNP cord-009571-mygj2nd4 669 32 cocultivations cocultivation NNS cord-009571-mygj2nd4 669 33 . . . cord-009571-mygj2nd4 670 1 These these DT cord-009571-mygj2nd4 670 2 VLPs vlp NNS cord-009571-mygj2nd4 670 3 were be VBD cord-009571-mygj2nd4 670 4 found find VBN cord-009571-mygj2nd4 670 5 budding bud VBG cord-009571-mygj2nd4 670 6 from from IN cord-009571-mygj2nd4 670 7 the the DT cord-009571-mygj2nd4 670 8 cell cell NN cord-009571-mygj2nd4 670 9 membranes membrane NNS cord-009571-mygj2nd4 670 10 , , , cord-009571-mygj2nd4 670 11 and and CC cord-009571-mygj2nd4 670 12 also also RB cord-009571-mygj2nd4 670 13 within within IN cord-009571-mygj2nd4 670 14 cytoplasmic cytoplasmic JJ cord-009571-mygj2nd4 670 15 vacuoles vacuole NNS cord-009571-mygj2nd4 670 16 . . . cord-009571-mygj2nd4 671 1 Their -PRON- PRP$ cord-009571-mygj2nd4 671 2 morphology morphology NN cord-009571-mygj2nd4 671 3 resembled resemble VBD cord-009571-mygj2nd4 671 4 that that DT cord-009571-mygj2nd4 671 5 of of IN cord-009571-mygj2nd4 671 6 budding bud VBG cord-009571-mygj2nd4 671 7 RNA RNA NNP cord-009571-mygj2nd4 671 8 viruses virus NNS cord-009571-mygj2nd4 671 9 , , , cord-009571-mygj2nd4 671 10 although although IN cord-009571-mygj2nd4 671 11 coronaviruses coronaviruse NNS cord-009571-mygj2nd4 671 12 and and CC cord-009571-mygj2nd4 671 13 myxoparamyxoviruses myxoparamyxoviruses NNP cord-009571-mygj2nd4 671 14 may may MD cord-009571-mygj2nd4 671 15 also also RB cord-009571-mygj2nd4 671 16 show show VB cord-009571-mygj2nd4 671 17 these these DT cord-009571-mygj2nd4 671 18 characteristics characteristic NNS cord-009571-mygj2nd4 671 19 in in IN cord-009571-mygj2nd4 671 20 certain certain JJ cord-009571-mygj2nd4 671 21 situations situation NNS cord-009571-mygj2nd4 671 22 . . . cord-009571-mygj2nd4 672 1 Similar similar JJ cord-009571-mygj2nd4 672 2 particles particle NNS cord-009571-mygj2nd4 672 3 have have VBP cord-009571-mygj2nd4 672 4 not not RB cord-009571-mygj2nd4 672 5 been be VBN cord-009571-mygj2nd4 672 6 previously previously RB cord-009571-mygj2nd4 672 7 demonstrated demonstrate VBN cord-009571-mygj2nd4 672 8 in in IN cord-009571-mygj2nd4 672 9 RSC RSC NNP cord-009571-mygj2nd4 672 10 . . . cord-009571-mygj2nd4 673 1 Serial serial JJ cord-009571-mygj2nd4 673 2 passage passage NN cord-009571-mygj2nd4 673 3 of of IN cord-009571-mygj2nd4 673 4 cocultivation cocultivation NN cord-009571-mygj2nd4 673 5 extracts extract NNS cord-009571-mygj2nd4 673 6 containing contain VBG cord-009571-mygj2nd4 673 7 VLPs vlp NNS cord-009571-mygj2nd4 673 8 onto onto IN cord-009571-mygj2nd4 673 9 other other JJ cord-009571-mygj2nd4 673 10 cell cell NN cord-009571-mygj2nd4 673 11 types type NNS cord-009571-mygj2nd4 673 12 resulted result VBD cord-009571-mygj2nd4 673 13 in in IN cord-009571-mygj2nd4 673 14 repeated repeat VBN cord-009571-mygj2nd4 673 15 transient transient JJ cord-009571-mygj2nd4 673 16 cytopathic cytopathic JJ cord-009571-mygj2nd4 673 17 effects effect NNS cord-009571-mygj2nd4 673 18 . . . cord-009571-mygj2nd4 674 1 Extracts extract NNS cord-009571-mygj2nd4 674 2 of of IN cord-009571-mygj2nd4 674 3 the the DT cord-009571-mygj2nd4 674 4 RSC RSC NNP cord-009571-mygj2nd4 674 5 cocultivations cocultivation NNS cord-009571-mygj2nd4 674 6 were be VBD cord-009571-mygj2nd4 674 7 injected inject VBN cord-009571-mygj2nd4 674 8 into into IN cord-009571-mygj2nd4 674 9 suckling suckle VBG cord-009571-mygj2nd4 674 10 mouse mouse NN cord-009571-mygj2nd4 674 11 brains brain NNS cord-009571-mygj2nd4 674 12 , , , cord-009571-mygj2nd4 674 13 resulting result VBG cord-009571-mygj2nd4 674 14 in in IN cord-009571-mygj2nd4 674 15 a a DT cord-009571-mygj2nd4 674 16 reproducible reproducible JJ cord-009571-mygj2nd4 674 17 illness illness NN cord-009571-mygj2nd4 674 18 not not RB cord-009571-mygj2nd4 674 19 observed observe VBD cord-009571-mygj2nd4 674 20 when when WRB cord-009571-mygj2nd4 674 21 control control NN cord-009571-mygj2nd4 674 22 extracts extract NNS cord-009571-mygj2nd4 674 23 were be VBD cord-009571-mygj2nd4 674 24 similarly similarly RB cord-009571-mygj2nd4 674 25 injected inject VBN cord-009571-mygj2nd4 674 26 . . . cord-009571-mygj2nd4 675 1 Additional additional JJ cord-009571-mygj2nd4 675 2 studies study NNS cord-009571-mygj2nd4 675 3 are be VBP cord-009571-mygj2nd4 675 4 under under IN cord-009571-mygj2nd4 675 5 way way NN cord-009571-mygj2nd4 675 6 to to TO cord-009571-mygj2nd4 675 7 identify identify VB cord-009571-mygj2nd4 675 8 the the DT cord-009571-mygj2nd4 675 9 agent agent NN cord-009571-mygj2nd4 675 10 and and CC cord-009571-mygj2nd4 675 11 to to TO cord-009571-mygj2nd4 675 12 explain explain VB cord-009571-mygj2nd4 675 13 its -PRON- PRP$ cord-009571-mygj2nd4 675 14 presence presence NN cord-009571-mygj2nd4 675 15 in in IN cord-009571-mygj2nd4 675 16 the the DT cord-009571-mygj2nd4 675 17 RSC RSC NNP cord-009571-mygj2nd4 675 18 cocultivation cocultivation NN cord-009571-mygj2nd4 675 19 systems system NNS cord-009571-mygj2nd4 675 20 . . . cord-009571-mygj2nd4 676 1 The the DT cord-009571-mygj2nd4 676 2 mechanism mechanism NN cord-009571-mygj2nd4 676 3 responsible responsible JJ cord-009571-mygj2nd4 676 4 for for IN cord-009571-mygj2nd4 676 5 leukopenia leukopenia NN cord-009571-mygj2nd4 676 6 in in IN cord-009571-mygj2nd4 676 7 Felty Felty NNP cord-009571-mygj2nd4 676 8 's 's POS cord-009571-mygj2nd4 676 9 syndrome syndrome NN cord-009571-mygj2nd4 676 10 ( ( -LRB- cord-009571-mygj2nd4 676 11 FS FS NNP cord-009571-mygj2nd4 676 12 ) ) -RRB- cord-009571-mygj2nd4 676 13 is be VBZ cord-009571-mygj2nd4 676 14 unknown unknown JJ cord-009571-mygj2nd4 676 15 . . . cord-009571-mygj2nd4 677 1 Both both DT cord-009571-mygj2nd4 677 2 increased increase VBN cord-009571-mygj2nd4 677 3 peripheral peripheral JJ cord-009571-mygj2nd4 677 4 destruction destruction NN cord-009571-mygj2nd4 677 5 of of IN cord-009571-mygj2nd4 677 6 leukocytes leukocyte NNS cord-009571-mygj2nd4 677 7 and and CC cord-009571-mygj2nd4 677 8 decreased decrease VBD cord-009571-mygj2nd4 677 9 marrow marrow NN cord-009571-mygj2nd4 677 10 production production NN cord-009571-mygj2nd4 677 11 may may MD cord-009571-mygj2nd4 677 12 play play VB cord-009571-mygj2nd4 677 13 a a DT cord-009571-mygj2nd4 677 14 role role NN cord-009571-mygj2nd4 677 15 in in IN cord-009571-mygj2nd4 677 16 this this DT cord-009571-mygj2nd4 677 17 process process NN cord-009571-mygj2nd4 677 18 . . . cord-009571-mygj2nd4 678 1 The the DT cord-009571-mygj2nd4 678 2 present present JJ cord-009571-mygj2nd4 678 3 study study NN cord-009571-mygj2nd4 678 4 was be VBD cord-009571-mygj2nd4 678 5 designed design VBN cord-009571-mygj2nd4 678 6 t t NNP cord-009571-mygj2nd4 678 7 o o UH cord-009571-mygj2nd4 678 8 determine determine NN cord-009571-mygj2nd4 678 9 whether whether IN cord-009571-mygj2nd4 678 10 factors factor NNS cord-009571-mygj2nd4 678 11 in in IN cord-009571-mygj2nd4 678 12 the the DT cord-009571-mygj2nd4 678 13 sera sera NNP cord-009571-mygj2nd4 678 14 of of IN cord-009571-mygj2nd4 678 15 patients patient NNS cord-009571-mygj2nd4 678 16 with with IN cord-009571-mygj2nd4 678 17 FS FS NNP cord-009571-mygj2nd4 678 18 inhibit inhibit VBP cord-009571-mygj2nd4 678 19 the the DT cord-009571-mygj2nd4 678 20 maturation maturation NN cord-009571-mygj2nd4 678 21 of of IN cord-009571-mygj2nd4 678 22 granulocyte granulocyte NN cord-009571-mygj2nd4 678 23 precursors precursor NNS cord-009571-mygj2nd4 678 24 from from IN cord-009571-mygj2nd4 678 25 human human JJ cord-009571-mygj2nd4 678 26 bone bone NN cord-009571-mygj2nd4 678 27 marrow marrow NN cord-009571-mygj2nd4 678 28 . . . cord-009571-mygj2nd4 679 1 Sera Sera NNP cord-009571-mygj2nd4 679 2 were be VBD cord-009571-mygj2nd4 679 3 obtained obtain VBN cord-009571-mygj2nd4 679 4 from from IN cord-009571-mygj2nd4 679 5 19 19 CD cord-009571-mygj2nd4 679 6 patients patient NNS cord-009571-mygj2nd4 679 7 with with IN cord-009571-mygj2nd4 679 8 FS FS NNP cord-009571-mygj2nd4 679 9 ; ; : cord-009571-mygj2nd4 679 10 10 10 CD cord-009571-mygj2nd4 679 11 patients patient NNS cord-009571-mygj2nd4 679 12 with with IN cord-009571-mygj2nd4 679 13 rheumatoid rheumatoid NN cord-009571-mygj2nd4 679 14 arthritis arthritis NN cord-009571-mygj2nd4 679 15 , , , cord-009571-mygj2nd4 679 16 splenomegaly splenomegaly NN cord-009571-mygj2nd4 679 17 , , , cord-009571-mygj2nd4 679 18 and and CC cord-009571-mygj2nd4 679 19 normal normal JJ cord-009571-mygj2nd4 679 20 white white JJ cord-009571-mygj2nd4 679 21 cell cell NN cord-009571-mygj2nd4 679 22 counts count NNS cord-009571-mygj2nd4 679 23 ; ; : cord-009571-mygj2nd4 679 24 9 9 CD cord-009571-mygj2nd4 679 25 patients patient NNS cord-009571-mygj2nd4 679 26 with with IN cord-009571-mygj2nd4 679 27 active active JJ cord-009571-mygj2nd4 679 28 RA RA NNP cord-009571-mygj2nd4 679 29 , , , cord-009571-mygj2nd4 679 30 and and CC cord-009571-mygj2nd4 679 31 10 10 CD cord-009571-mygj2nd4 679 32 patients patient NNS cord-009571-mygj2nd4 679 33 with with IN cord-009571-mygj2nd4 679 34 osteoarthritis osteoarthritis NN cord-009571-mygj2nd4 679 35 . . . cord-009571-mygj2nd4 680 1 Nucleated nucleated NN cord-009571-mygj2nd4 680 2 cells cell NNS cord-009571-mygj2nd4 680 3 were be VBD cord-009571-mygj2nd4 680 4 isolated isolate VBN cord-009571-mygj2nd4 680 5 from from IN cord-009571-mygj2nd4 680 6 human human JJ cord-009571-mygj2nd4 680 7 marrow marrow NN cord-009571-mygj2nd4 680 8 , , , cord-009571-mygj2nd4 680 9 and and CC cord-009571-mygj2nd4 680 10 single single JJ cord-009571-mygj2nd4 680 11 cell cell NN cord-009571-mygj2nd4 680 12 suspensions suspension NNS cord-009571-mygj2nd4 680 13 were be VBD cord-009571-mygj2nd4 680 14 cultured culture VBN cord-009571-mygj2nd4 680 15 in in IN cord-009571-mygj2nd4 680 16 McCoy McCoy NNP cord-009571-mygj2nd4 680 17 's 's POS cord-009571-mygj2nd4 680 18 medium medium JJ cord-009571-mygj2nd4 680 19 and and CC cord-009571-mygj2nd4 680 20 fetal fetal JJ cord-009571-mygj2nd4 680 21 calf calf NN cord-009571-mygj2nd4 680 22 serum serum NN cord-009571-mygj2nd4 680 23 . . . cord-009571-mygj2nd4 681 1 The the DT cord-009571-mygj2nd4 681 2 serum serum NN cord-009571-mygj2nd4 681 3 to to TO cord-009571-mygj2nd4 681 4 be be VB cord-009571-mygj2nd4 681 5 tested test VBN cord-009571-mygj2nd4 681 6 , , , cord-009571-mygj2nd4 681 7 0.1 0.1 CD cord-009571-mygj2nd4 681 8 ml ml NNS cord-009571-mygj2nd4 681 9 , , , cord-009571-mygj2nd4 681 10 was be VBD cord-009571-mygj2nd4 681 11 incubated incubate VBN cord-009571-mygj2nd4 681 12 with with IN cord-009571-mygj2nd4 681 13 0.1 0.1 CD cord-009571-mygj2nd4 681 14 ml ml NNS cord-009571-mygj2nd4 681 15 of of IN cord-009571-mygj2nd4 681 16 the the DT cord-009571-mygj2nd4 681 17 cell cell NN cord-009571-mygj2nd4 681 18 suspension suspension NN cord-009571-mygj2nd4 681 19 ( ( -LRB- cord-009571-mygj2nd4 681 20 containing contain VBG cord-009571-mygj2nd4 681 21 10 10 CD cord-009571-mygj2nd4 681 22 X x SYM cord-009571-mygj2nd4 681 23 10 10 CD cord-009571-mygj2nd4 681 24 ' ' POS cord-009571-mygj2nd4 681 25 cells cell NNS cord-009571-mygj2nd4 681 26 / / SYM cord-009571-mygj2nd4 681 27 ml ml NN cord-009571-mygj2nd4 681 28 ) ) -RRB- cord-009571-mygj2nd4 681 29 and and CC cord-009571-mygj2nd4 681 30 0.1 0.1 CD cord-009571-mygj2nd4 681 31 ml ml NN cord-009571-mygj2nd4 681 32 rabbit rabbit NN cord-009571-mygj2nd4 681 33 serum serum NN cord-009571-mygj2nd4 681 34 , , , cord-009571-mygj2nd4 681 35 and and CC cord-009571-mygj2nd4 681 36 the the DT cord-009571-mygj2nd4 681 37 mixture mixture NN cord-009571-mygj2nd4 681 38 was be VBD cord-009571-mygj2nd4 681 39 placed place VBN cord-009571-mygj2nd4 681 40 in in IN cord-009571-mygj2nd4 681 41 3 3 CD cord-009571-mygj2nd4 681 42 % % NN cord-009571-mygj2nd4 681 43 agar agar NN cord-009571-mygj2nd4 681 44 . . . cord-009571-mygj2nd4 682 1 At at IN cord-009571-mygj2nd4 682 2 the the DT cord-009571-mygj2nd4 682 3 end end NN cord-009571-mygj2nd4 682 4 of of IN cord-009571-mygj2nd4 682 5 12 12 CD cord-009571-mygj2nd4 682 6 days day NNS cord-009571-mygj2nd4 682 7 , , , cord-009571-mygj2nd4 682 8 the the DT cord-009571-mygj2nd4 682 9 number number NN cord-009571-mygj2nd4 682 10 of of IN cord-009571-mygj2nd4 682 11 cells cell NNS cord-009571-mygj2nd4 682 12 giving give VBG cord-009571-mygj2nd4 682 13 rise rise NN cord-009571-mygj2nd4 682 14 to to IN cord-009571-mygj2nd4 682 15 granulocyte granulocyte NN cord-009571-mygj2nd4 682 16 - - HYPH cord-009571-mygj2nd4 682 17 macrophage macrophage NN cord-009571-mygj2nd4 682 18 colonies colony NNS cord-009571-mygj2nd4 682 19 ( ( -LRB- cord-009571-mygj2nd4 682 20 CFU CFU NNP cord-009571-mygj2nd4 682 21 - - HYPH cord-009571-mygj2nd4 682 22 C C NNP cord-009571-mygj2nd4 682 23 ) ) -RRB- cord-009571-mygj2nd4 682 24 were be VBD cord-009571-mygj2nd4 682 25 counted count VBN cord-009571-mygj2nd4 682 26 . . . cord-009571-mygj2nd4 683 1 Serum serum NN cord-009571-mygj2nd4 683 2 from from IN cord-009571-mygj2nd4 683 3 a a DT cord-009571-mygj2nd4 683 4 healthy healthy JJ cord-009571-mygj2nd4 683 5 adult adult NN cord-009571-mygj2nd4 683 6 was be VBD cord-009571-mygj2nd4 683 7 run run VBN cord-009571-mygj2nd4 683 8 simultaneously simultaneously RB cord-009571-mygj2nd4 683 9 as as IN cord-009571-mygj2nd4 683 10 a a DT cord-009571-mygj2nd4 683 11 control control NN cord-009571-mygj2nd4 683 12 . . . cord-009571-mygj2nd4 684 1 Inhibition inhibition NN cord-009571-mygj2nd4 684 2 of of IN cord-009571-mygj2nd4 684 3 maturation maturation NN cord-009571-mygj2nd4 684 4 was be VBD cord-009571-mygj2nd4 684 5 considered consider VBN cord-009571-mygj2nd4 684 6 to to TO cord-009571-mygj2nd4 684 7 be be VB cord-009571-mygj2nd4 684 8 present present JJ cord-009571-mygj2nd4 684 9 if if IN cord-009571-mygj2nd4 684 10 the the DT cord-009571-mygj2nd4 684 11 number number NN cord-009571-mygj2nd4 684 12 of of IN cord-009571-mygj2nd4 684 13 CFU CFU NNP cord-009571-mygj2nd4 684 14 - - HYPH cord-009571-mygj2nd4 684 15 C C NNP cord-009571-mygj2nd4 684 16 in in IN cord-009571-mygj2nd4 684 17 the the DT cord-009571-mygj2nd4 684 18 agar agar NN cord-009571-mygj2nd4 684 19 incubated incubate VBN cord-009571-mygj2nd4 684 20 with with IN cord-009571-mygj2nd4 684 21 the the DT cord-009571-mygj2nd4 684 22 test test NN cord-009571-mygj2nd4 684 23 serum serum NN cord-009571-mygj2nd4 684 24 was be VBD cord-009571-mygj2nd4 684 25 reduced reduce VBN cord-009571-mygj2nd4 684 26 by by IN cord-009571-mygj2nd4 684 27 at at RB cord-009571-mygj2nd4 684 28 least least RBS cord-009571-mygj2nd4 684 29 25 25 CD cord-009571-mygj2nd4 684 30 % % NN cord-009571-mygj2nd4 684 31 as as IN cord-009571-mygj2nd4 684 32 compared compare VBN cord-009571-mygj2nd4 684 33 to to IN cord-009571-mygj2nd4 684 34 healthy healthy JJ cord-009571-mygj2nd4 684 35 control control NN cord-009571-mygj2nd4 684 36 serum serum NN cord-009571-mygj2nd4 684 37 . . . cord-009571-mygj2nd4 685 1 Sera Sera NNP cord-009571-mygj2nd4 685 2 from from IN cord-009571-mygj2nd4 685 3 8 8 CD cord-009571-mygj2nd4 685 4 of of IN cord-009571-mygj2nd4 685 5 19 19 CD cord-009571-mygj2nd4 685 6 patients patient NNS cord-009571-mygj2nd4 685 7 with with IN cord-009571-mygj2nd4 685 8 FS FS NNP cord-009571-mygj2nd4 685 9 caused cause VBD cord-009571-mygj2nd4 685 10 a a DT cord-009571-mygj2nd4 685 11 significant significant JJ cord-009571-mygj2nd4 685 12 reduction reduction NN cord-009571-mygj2nd4 685 13 in in IN cord-009571-mygj2nd4 685 14 the the DT cord-009571-mygj2nd4 685 15 number number NN cord-009571-mygj2nd4 685 16 of of IN cord-009571-mygj2nd4 685 17 CFU CFU NNP cord-009571-mygj2nd4 685 18 - - HYPH cord-009571-mygj2nd4 685 19 C. C. NNP cord-009571-mygj2nd4 685 20 Seven Seven NNP cord-009571-mygj2nd4 685 21 of of IN cord-009571-mygj2nd4 685 22 the the DT cord-009571-mygj2nd4 685 23 8 8 CD cord-009571-mygj2nd4 685 24 patients patient NNS cord-009571-mygj2nd4 685 25 with with IN cord-009571-mygj2nd4 685 26 serum serum NN cord-009571-mygj2nd4 685 27 inhibitors inhibitor NNS cord-009571-mygj2nd4 685 28 had have VBD cord-009571-mygj2nd4 685 29 undergone undergo VBN cord-009571-mygj2nd4 685 30 splenectomy splenectomy NN cord-009571-mygj2nd4 685 31 ; ; : cord-009571-mygj2nd4 685 32 in in IN cord-009571-mygj2nd4 685 33 3 3 CD cord-009571-mygj2nd4 685 34 of of IN cord-009571-mygj2nd4 685 35 these these DT cord-009571-mygj2nd4 685 36 subjects subject NNS cord-009571-mygj2nd4 685 37 the the DT cord-009571-mygj2nd4 685 38 inhibitor inhibitor NN cord-009571-mygj2nd4 685 39 was be VBD cord-009571-mygj2nd4 685 40 absent absent JJ cord-009571-mygj2nd4 685 41 prior prior RB cord-009571-mygj2nd4 685 42 to to IN cord-009571-mygj2nd4 685 43 splenectomy splenectomy NN cord-009571-mygj2nd4 685 44 , , , cord-009571-mygj2nd4 685 45 but but CC cord-009571-mygj2nd4 685 46 present present JJ cord-009571-mygj2nd4 685 47 after after IN cord-009571-mygj2nd4 685 48 splenectomy splenectomy NN cord-009571-mygj2nd4 685 49 . . . cord-009571-mygj2nd4 686 1 None none NN cord-009571-mygj2nd4 686 2 of of IN cord-009571-mygj2nd4 686 3 the the DT cord-009571-mygj2nd4 686 4 sera sera NNP cord-009571-mygj2nd4 686 5 from from IN cord-009571-mygj2nd4 686 6 the the DT cord-009571-mygj2nd4 686 7 29 29 CD cord-009571-mygj2nd4 686 8 control control NN cord-009571-mygj2nd4 686 9 subjects subject NNS cord-009571-mygj2nd4 686 10 gave give VBD cord-009571-mygj2nd4 686 11 a a DT cord-009571-mygj2nd4 686 12 positive positive JJ cord-009571-mygj2nd4 686 13 response response NN cord-009571-mygj2nd4 686 14 . . . cord-009571-mygj2nd4 687 1 These these DT cord-009571-mygj2nd4 687 2 data datum NNS cord-009571-mygj2nd4 687 3 indicate indicate VBP cord-009571-mygj2nd4 687 4 that that IN cord-009571-mygj2nd4 687 5 the the DT cord-009571-mygj2nd4 687 6 sera sera NNP cord-009571-mygj2nd4 687 7 of of IN cord-009571-mygj2nd4 687 8 certain certain JJ cord-009571-mygj2nd4 687 9 patients patient NNS cord-009571-mygj2nd4 687 10 with with IN cord-009571-mygj2nd4 687 11 FS FS NNP cord-009571-mygj2nd4 687 12 contain contain VBP cord-009571-mygj2nd4 687 13 a a DT cord-009571-mygj2nd4 687 14 factor factor NN cord-009571-mygj2nd4 687 15 that that WDT cord-009571-mygj2nd4 687 16 inhibits inhibit VBZ cord-009571-mygj2nd4 687 17 human human JJ cord-009571-mygj2nd4 687 18 granulocyte granulocyte NN cord-009571-mygj2nd4 687 19 precursors precursor NNS cord-009571-mygj2nd4 687 20 in in IN cord-009571-mygj2nd4 687 21 vitro vitro FW cord-009571-mygj2nd4 687 22 . . . cord-009571-mygj2nd4 688 1 This this DT cord-009571-mygj2nd4 688 2 factor factor NN cord-009571-mygj2nd4 688 3 may may MD cord-009571-mygj2nd4 688 4 play play VB cord-009571-mygj2nd4 688 5 a a DT cord-009571-mygj2nd4 688 6 role role NN cord-009571-mygj2nd4 688 7 in in IN cord-009571-mygj2nd4 688 8 the the DT cord-009571-mygj2nd4 688 9 induction induction NN cord-009571-mygj2nd4 688 10 of of IN cord-009571-mygj2nd4 688 11 leukopenia leukopenia NN cord-009571-mygj2nd4 688 12 in in IN cord-009571-mygj2nd4 688 13 FS FS NNP cord-009571-mygj2nd4 688 14 . . . cord-009571-mygj2nd4 689 1 The the DT cord-009571-mygj2nd4 689 2 presence presence NN cord-009571-mygj2nd4 689 3 of of IN cord-009571-mygj2nd4 689 4 a a DT cord-009571-mygj2nd4 689 5 serum serum NN cord-009571-mygj2nd4 689 6 inhibitor inhibitor NN cord-009571-mygj2nd4 689 7 of of IN cord-009571-mygj2nd4 689 8 granulocyte granulocyte NN cord-009571-mygj2nd4 689 9 maturation maturation NN cord-009571-mygj2nd4 689 10 may may MD cord-009571-mygj2nd4 689 11 also also RB cord-009571-mygj2nd4 689 12 explain explain VB cord-009571-mygj2nd4 689 13 the the DT cord-009571-mygj2nd4 689 14 failure failure NN cord-009571-mygj2nd4 689 15 of of IN cord-009571-mygj2nd4 689 16 some some DT cord-009571-mygj2nd4 689 17 patients patient NNS cord-009571-mygj2nd4 689 18 with with IN cord-009571-mygj2nd4 689 19 FS FS NNP cord-009571-mygj2nd4 689 20 to to TO cord-009571-mygj2nd4 689 21 respond respond VB cord-009571-mygj2nd4 689 22 to to IN cord-009571-mygj2nd4 689 23 splenectomy splenectomy NN cord-009571-mygj2nd4 689 24 . . . cord-009571-mygj2nd4 690 1 This this DT cord-009571-mygj2nd4 690 2 study study NN cord-009571-mygj2nd4 690 3 was be VBD cord-009571-mygj2nd4 690 4 designed design VBN cord-009571-mygj2nd4 690 5 to to TO cord-009571-mygj2nd4 690 6 determine determine VB cord-009571-mygj2nd4 690 7 - - : cord-009571-mygj2nd4 690 8 whether whether IN cord-009571-mygj2nd4 690 9 lymphocytotoxic lymphocytotoxic NNP cord-009571-mygj2nd4 690 10 antibodies antibody NNS cord-009571-mygj2nd4 690 11 ( ( -LRB- cord-009571-mygj2nd4 690 12 LCA LCA NNP cord-009571-mygj2nd4 690 13 ) ) -RRB- cord-009571-mygj2nd4 690 14 in in IN cord-009571-mygj2nd4 690 15 patients patient NNS cord-009571-mygj2nd4 690 16 with with IN cord-009571-mygj2nd4 690 17 SLE SLE NNP cord-009571-mygj2nd4 690 18 had have VBD cord-009571-mygj2nd4 690 19 specificity specificity NN cord-009571-mygj2nd4 690 20 for for IN cord-009571-mygj2nd4 690 21 the the DT cord-009571-mygj2nd4 690 22 Ii Ii NNP cord-009571-mygj2nd4 690 23 antigen antigen NN cord-009571-mygj2nd4 690 24 system system NN cord-009571-mygj2nd4 690 25 ; ; : cord-009571-mygj2nd4 690 26 the the DT cord-009571-mygj2nd4 690 27 Ii Ii NNP cord-009571-mygj2nd4 690 28 antigens antigen NNS cord-009571-mygj2nd4 690 29 are be VBP cord-009571-mygj2nd4 690 30 known know VBN cord-009571-mygj2nd4 690 31 to to TO cord-009571-mygj2nd4 690 32 be be VB cord-009571-mygj2nd4 690 33 present present JJ cord-009571-mygj2nd4 690 34 on on IN cord-009571-mygj2nd4 690 35 the the DT cord-009571-mygj2nd4 690 36 surface surface NN cord-009571-mygj2nd4 690 37 of of IN cord-009571-mygj2nd4 690 38 all all DT cord-009571-mygj2nd4 690 39 formed form VBN cord-009571-mygj2nd4 690 40 elements element NNS cord-009571-mygj2nd4 690 41 in in IN cord-009571-mygj2nd4 690 42 blood blood NN cord-009571-mygj2nd4 690 43 . . . cord-009571-mygj2nd4 691 1 Sera Sera NNP cord-009571-mygj2nd4 691 2 from from IN cord-009571-mygj2nd4 691 3 10 10 CD cord-009571-mygj2nd4 691 4 patients patient NNS cord-009571-mygj2nd4 691 5 with with IN cord-009571-mygj2nd4 691 6 SLE SLE NNP cord-009571-mygj2nd4 691 7 were be VBD cord-009571-mygj2nd4 691 8 tested test VBN cord-009571-mygj2nd4 691 9 for for IN cord-009571-mygj2nd4 691 10 LCA LCA NNP cord-009571-mygj2nd4 691 11 using use VBG cord-009571-mygj2nd4 691 12 the the DT cord-009571-mygj2nd4 691 13 standard standard JJ cord-009571-mygj2nd4 691 14 microdroplet microdroplet NN cord-009571-mygj2nd4 691 15 assay assay NN cord-009571-mygj2nd4 691 16 . . . cord-009571-mygj2nd4 692 1 Following follow VBG cord-009571-mygj2nd4 692 2 determination determination NN cord-009571-mygj2nd4 692 3 of of IN cord-009571-mygj2nd4 692 4 the the DT cord-009571-mygj2nd4 692 5 LCA LCA NNP cord-009571-mygj2nd4 692 6 in in IN cord-009571-mygj2nd4 692 7 whole whole JJ cord-009571-mygj2nd4 692 8 sera sera NNP cord-009571-mygj2nd4 692 9 , , , cord-009571-mygj2nd4 692 10 each each DT cord-009571-mygj2nd4 692 11 serum serum NN cord-009571-mygj2nd4 692 12 was be VBD cord-009571-mygj2nd4 692 13 serially serially RB cord-009571-mygj2nd4 692 14 diluted dilute VBN cord-009571-mygj2nd4 692 15 twofold twofold NN cord-009571-mygj2nd4 692 16 in in IN cord-009571-mygj2nd4 692 17 saline saline NN cord-009571-mygj2nd4 692 18 and and CC cord-009571-mygj2nd4 692 19 retested reteste VBN cord-009571-mygj2nd4 692 20 for for IN cord-009571-mygj2nd4 692 21 LCA LCA NNP cord-009571-mygj2nd4 692 22 . . . cord-009571-mygj2nd4 693 1 The the DT cord-009571-mygj2nd4 693 2 dilution dilution NN cord-009571-mygj2nd4 693 3 of of IN cord-009571-mygj2nd4 693 4 the the DT cord-009571-mygj2nd4 693 5 serum serum NN cord-009571-mygj2nd4 693 6 which which WDT cord-009571-mygj2nd4 693 7 gave give VBD cord-009571-mygj2nd4 693 8 a a DT cord-009571-mygj2nd4 693 9 50 50 CD cord-009571-mygj2nd4 693 10 % % NN cord-009571-mygj2nd4 693 11 decrease decrease NN cord-009571-mygj2nd4 693 12 in in IN cord-009571-mygj2nd4 693 13 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 693 14 was be VBD cord-009571-mygj2nd4 693 15 used use VBN cord-009571-mygj2nd4 693 16 in in IN cord-009571-mygj2nd4 693 17 the the DT cord-009571-mygj2nd4 693 18 following follow VBG cord-009571-mygj2nd4 693 19 absorption absorption NN cord-009571-mygj2nd4 693 20 experiments experiment NNS cord-009571-mygj2nd4 693 21 . . . cord-009571-mygj2nd4 694 1 Each each DT cord-009571-mygj2nd4 694 2 diluted diluted JJ cord-009571-mygj2nd4 694 3 serum serum NN cord-009571-mygj2nd4 694 4 was be VBD cord-009571-mygj2nd4 694 5 absorbed absorb VBN cord-009571-mygj2nd4 694 6 threefold threefold RB cord-009571-mygj2nd4 694 7 with with IN cord-009571-mygj2nd4 694 8 either either DT cord-009571-mygj2nd4 694 9 adult adult NN cord-009571-mygj2nd4 694 10 ( ( -LRB- cord-009571-mygj2nd4 694 11 rich rich JJ cord-009571-mygj2nd4 694 12 in in IN cord-009571-mygj2nd4 694 13 I -PRON- PRP cord-009571-mygj2nd4 694 14 antigen antigen NNP cord-009571-mygj2nd4 694 15 ) ) -RRB- cord-009571-mygj2nd4 694 16 or or CC cord-009571-mygj2nd4 694 17 cord cord NN cord-009571-mygj2nd4 694 18 ( ( -LRB- cord-009571-mygj2nd4 694 19 rich rich JJ cord-009571-mygj2nd4 694 20 in in IN cord-009571-mygj2nd4 694 21 i i NNP cord-009571-mygj2nd4 694 22 antigen antigen NNP cord-009571-mygj2nd4 694 23 ) ) -RRB- cord-009571-mygj2nd4 694 24 red red JJ cord-009571-mygj2nd4 694 25 cells cell NNS cord-009571-mygj2nd4 694 26 a a DT cord-009571-mygj2nd4 694 27 t t NN cord-009571-mygj2nd4 694 28 4"C 4"c CD cord-009571-mygj2nd4 694 29 , , , cord-009571-mygj2nd4 694 30 and and CC cord-009571-mygj2nd4 694 31 then then RB cord-009571-mygj2nd4 694 32 retested reteste VBD cord-009571-mygj2nd4 694 33 for for IN cord-009571-mygj2nd4 694 34 LCA LCA NNP cord-009571-mygj2nd4 694 35 activity activity NN cord-009571-mygj2nd4 694 36 . . . cord-009571-mygj2nd4 695 1 Eluates Eluates NNPS cord-009571-mygj2nd4 695 2 were be VBD cord-009571-mygj2nd4 695 3 prepared prepare VBN cord-009571-mygj2nd4 695 4 from from IN cord-009571-mygj2nd4 695 5 2 2 CD cord-009571-mygj2nd4 695 6 sera sera NNP cord-009571-mygj2nd4 695 7 incubated incubate VBN cord-009571-mygj2nd4 695 8 with with IN cord-009571-mygj2nd4 695 9 either either CC cord-009571-mygj2nd4 695 10 adult adult NN cord-009571-mygj2nd4 695 11 or or CC cord-009571-mygj2nd4 695 12 cord cord NN cord-009571-mygj2nd4 695 13 cells cell VBZ cord-009571-mygj2nd4 695 14 a a DT cord-009571-mygj2nd4 695 15 t t NN cord-009571-mygj2nd4 695 16 4"C 4"c CD cord-009571-mygj2nd4 695 17 , , , cord-009571-mygj2nd4 695 18 and and CC cord-009571-mygj2nd4 695 19 the the DT cord-009571-mygj2nd4 695 20 eluates eluate NNS cord-009571-mygj2nd4 695 21 assayed assay VBN cord-009571-mygj2nd4 695 22 for for IN cord-009571-mygj2nd4 695 23 LCA LCA NNP cord-009571-mygj2nd4 695 24 . . . cord-009571-mygj2nd4 696 1 The the DT cord-009571-mygj2nd4 696 2 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 696 3 of of IN cord-009571-mygj2nd4 696 4 the the DT cord-009571-mygj2nd4 696 5 whole whole JJ cord-009571-mygj2nd4 696 6 sera sera NNP cord-009571-mygj2nd4 696 7 was be VBD cord-009571-mygj2nd4 696 8 79 79 CD cord-009571-mygj2nd4 696 9 % % NN cord-009571-mygj2nd4 696 10 or or CC cord-009571-mygj2nd4 696 11 greater great JJR cord-009571-mygj2nd4 696 12 in in IN cord-009571-mygj2nd4 696 13 all all DT cord-009571-mygj2nd4 696 14 but but CC cord-009571-mygj2nd4 696 15 one one CD cord-009571-mygj2nd4 696 16 serum serum NN cord-009571-mygj2nd4 696 17 . . . cord-009571-mygj2nd4 697 1 Seven seven CD cord-009571-mygj2nd4 697 2 of of IN cord-009571-mygj2nd4 697 3 the the DT cord-009571-mygj2nd4 697 4 diluted dilute VBN cord-009571-mygj2nd4 697 5 sera sera NNP cord-009571-mygj2nd4 697 6 showed show VBD cord-009571-mygj2nd4 697 7 an an DT cord-009571-mygj2nd4 697 8 obvious obvious JJ cord-009571-mygj2nd4 697 9 reduction reduction NN cord-009571-mygj2nd4 697 10 in in IN cord-009571-mygj2nd4 697 11 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 697 12 following follow VBG cord-009571-mygj2nd4 697 13 absorption absorption NN cord-009571-mygj2nd4 697 14 with with IN cord-009571-mygj2nd4 697 15 cord cord NN cord-009571-mygj2nd4 697 16 cells cell NNS cord-009571-mygj2nd4 697 17 , , , cord-009571-mygj2nd4 697 18 but but CC cord-009571-mygj2nd4 697 19 minimal minimal JJ cord-009571-mygj2nd4 697 20 or or CC cord-009571-mygj2nd4 697 21 n n NN cord-009571-mygj2nd4 697 22 o o NN cord-009571-mygj2nd4 697 23 reduction reduction NN cord-009571-mygj2nd4 697 24 after after IN cord-009571-mygj2nd4 697 25 absorption absorption NN cord-009571-mygj2nd4 697 26 with with IN cord-009571-mygj2nd4 697 27 adult adult NN cord-009571-mygj2nd4 697 28 erythrocytes erythrocyte NNS cord-009571-mygj2nd4 697 29 . . . cord-009571-mygj2nd4 698 1 Of of IN cord-009571-mygj2nd4 698 2 the the DT cord-009571-mygj2nd4 698 3 remaining remain VBG cord-009571-mygj2nd4 698 4 3 3 CD cord-009571-mygj2nd4 698 5 sera sera NNP cord-009571-mygj2nd4 698 6 , , , cord-009571-mygj2nd4 698 7 the the DT cord-009571-mygj2nd4 698 8 LCA LCA NNP cord-009571-mygj2nd4 698 9 were be VBD cord-009571-mygj2nd4 698 10 equally equally RB cord-009571-mygj2nd4 698 11 reduced reduce VBN cord-009571-mygj2nd4 698 12 by by IN cord-009571-mygj2nd4 698 13 adult adult NN cord-009571-mygj2nd4 698 14 and and CC cord-009571-mygj2nd4 698 15 cord cord NN cord-009571-mygj2nd4 698 16 cells cell NNS cord-009571-mygj2nd4 698 17 in in IN cord-009571-mygj2nd4 698 18 1 1 CD cord-009571-mygj2nd4 698 19 , , , cord-009571-mygj2nd4 698 20 and and CC cord-009571-mygj2nd4 698 21 were be VBD cord-009571-mygj2nd4 698 22 unaffected unaffected JJ cord-009571-mygj2nd4 698 23 by by IN cord-009571-mygj2nd4 698 24 absorption absorption NN cord-009571-mygj2nd4 698 25 in in IN cord-009571-mygj2nd4 698 26 2 2 CD cord-009571-mygj2nd4 698 27 . . . cord-009571-mygj2nd4 699 1 In in IN cord-009571-mygj2nd4 699 2 the the DT cord-009571-mygj2nd4 699 3 2 2 CD cord-009571-mygj2nd4 699 4 sera sera NNP cord-009571-mygj2nd4 699 5 studied study VBD cord-009571-mygj2nd4 699 6 , , , cord-009571-mygj2nd4 699 7 eluates eluate NNS cord-009571-mygj2nd4 699 8 prepared prepare VBD cord-009571-mygj2nd4 699 9 from from IN cord-009571-mygj2nd4 699 10 cord cord NN cord-009571-mygj2nd4 699 11 cells cell NNS cord-009571-mygj2nd4 699 12 showed show VBD cord-009571-mygj2nd4 699 13 greater great JJR cord-009571-mygj2nd4 699 14 LCA LCA NNP cord-009571-mygj2nd4 699 15 activity activity NN cord-009571-mygj2nd4 699 16 than than IN cord-009571-mygj2nd4 699 17 eluates eluate NNS cord-009571-mygj2nd4 699 18 from from IN cord-009571-mygj2nd4 699 19 adult adult NN cord-009571-mygj2nd4 699 20 cells cell NNS cord-009571-mygj2nd4 699 21 . . . cord-009571-mygj2nd4 700 1 Statistical statistical JJ cord-009571-mygj2nd4 700 2 analysis analysis NN cord-009571-mygj2nd4 700 3 confirmed confirm VBD cord-009571-mygj2nd4 700 4 that that IN cord-009571-mygj2nd4 700 5 the the DT cord-009571-mygj2nd4 700 6 mean mean JJ cord-009571-mygj2nd4 700 7 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 700 8 values value NNS cord-009571-mygj2nd4 700 9 in in IN cord-009571-mygj2nd4 700 10 the the DT cord-009571-mygj2nd4 700 11 sera sera NNP cord-009571-mygj2nd4 700 12 after after IN cord-009571-mygj2nd4 700 13 absorption absorption NN cord-009571-mygj2nd4 700 14 with with IN cord-009571-mygj2nd4 700 15 cord cord NN cord-009571-mygj2nd4 700 16 cells cell NNS cord-009571-mygj2nd4 700 17 were be VBD cord-009571-mygj2nd4 700 18 significantly significantly RB cord-009571-mygj2nd4 700 19 different different JJ cord-009571-mygj2nd4 700 20 from from IN cord-009571-mygj2nd4 700 21 those those DT cord-009571-mygj2nd4 700 22 obtained obtain VBN cord-009571-mygj2nd4 700 23 after after IN cord-009571-mygj2nd4 700 24 absorption absorption NN cord-009571-mygj2nd4 700 25 with with IN cord-009571-mygj2nd4 700 26 adult adult NN cord-009571-mygj2nd4 700 27 cells cell NNS cord-009571-mygj2nd4 700 28 ( ( -LRB- cord-009571-mygj2nd4 700 29 P p NN cord-009571-mygj2nd4 700 30 < < XX cord-009571-mygj2nd4 700 31 0.005 0.005 CD cord-009571-mygj2nd4 700 32 ) ) -RRB- cord-009571-mygj2nd4 700 33 . . . cord-009571-mygj2nd4 701 1 Additional additional JJ cord-009571-mygj2nd4 701 2 studies study NNS cord-009571-mygj2nd4 701 3 showed show VBD cord-009571-mygj2nd4 701 4 that that IN cord-009571-mygj2nd4 701 5 there there EX cord-009571-mygj2nd4 701 6 was be VBD cord-009571-mygj2nd4 701 7 a a DT cord-009571-mygj2nd4 701 8 strong strong JJ cord-009571-mygj2nd4 701 9 correlation correlation NN cord-009571-mygj2nd4 701 10 between between IN cord-009571-mygj2nd4 701 11 the the DT cord-009571-mygj2nd4 701 12 level level NN cord-009571-mygj2nd4 701 13 of of IN cord-009571-mygj2nd4 701 14 LCA LCA NNP cord-009571-mygj2nd4 701 15 and and CC cord-009571-mygj2nd4 701 16 the the DT cord-009571-mygj2nd4 701 17 titers titer NNS cord-009571-mygj2nd4 701 18 of of IN cord-009571-mygj2nd4 701 19 cold cold JJ cord-009571-mygj2nd4 701 20 agglutinins agglutinin NNS cord-009571-mygj2nd4 701 21 against against IN cord-009571-mygj2nd4 701 22 cord cord NN cord-009571-mygj2nd4 701 23 red red JJ cord-009571-mygj2nd4 701 24 cells cell NNS cord-009571-mygj2nd4 701 25 . . . cord-009571-mygj2nd4 702 1 These these DT cord-009571-mygj2nd4 702 2 data datum NNS cord-009571-mygj2nd4 702 3 indicate indicate VBP cord-009571-mygj2nd4 702 4 that that IN cord-009571-mygj2nd4 702 5 the the DT cord-009571-mygj2nd4 702 6 LCA LCA NNP cord-009571-mygj2nd4 702 7 in in IN cord-009571-mygj2nd4 702 8 most most JJS cord-009571-mygj2nd4 702 9 SLE SLE NNP cord-009571-mygj2nd4 702 10 sera sera NNP cord-009571-mygj2nd4 702 11 react react VB cord-009571-mygj2nd4 702 12 with with IN cord-009571-mygj2nd4 702 13 i i PRP cord-009571-mygj2nd4 702 14 antigen antigen NNP cord-009571-mygj2nd4 702 15 . . . cord-009571-mygj2nd4 703 1 Cold cold JJ cord-009571-mygj2nd4 703 2 - - HYPH cord-009571-mygj2nd4 703 3 reactive reactive JJ cord-009571-mygj2nd4 703 4 antibodies antibody NNS cord-009571-mygj2nd4 703 5 with with IN cord-009571-mygj2nd4 703 6 i i PRP cord-009571-mygj2nd4 703 7 specificity specificity NN cord-009571-mygj2nd4 703 8 have have VBP cord-009571-mygj2nd4 703 9 been be VBN cord-009571-mygj2nd4 703 10 associated associate VBN cord-009571-mygj2nd4 703 11 with with IN cord-009571-mygj2nd4 703 12 hemolytic hemolytic JJ cord-009571-mygj2nd4 703 13 anemia anemia NN cord-009571-mygj2nd4 703 14 and and CC cord-009571-mygj2nd4 703 15 thrombocytopenia thrombocytopenia NN cord-009571-mygj2nd4 703 16 in in IN cord-009571-mygj2nd4 703 17 other other JJ cord-009571-mygj2nd4 703 18 disease disease NN cord-009571-mygj2nd4 703 19 , , , cord-009571-mygj2nd4 703 20 thus thus RB cord-009571-mygj2nd4 703 21 , , , cord-009571-mygj2nd4 703 22 the the DT cord-009571-mygj2nd4 703 23 capability capability NN cord-009571-mygj2nd4 703 24 of of IN cord-009571-mygj2nd4 703 25 LCA LCA NNP cord-009571-mygj2nd4 703 26 to to TO cord-009571-mygj2nd4 703 27 react react VB cord-009571-mygj2nd4 703 28 with with IN cord-009571-mygj2nd4 703 29 i i PRP cord-009571-mygj2nd4 703 30 antigen antigen NN cord-009571-mygj2nd4 703 31 may may MD cord-009571-mygj2nd4 703 32 explain explain VB cord-009571-mygj2nd4 703 33 the the DT cord-009571-mygj2nd4 703 34 observation observation NN cord-009571-mygj2nd4 703 35 that that IN cord-009571-mygj2nd4 703 36 LCA LCA NNP cord-009571-mygj2nd4 703 37 were be VBD cord-009571-mygj2nd4 703 38 found find VBN cord-009571-mygj2nd4 703 39 in in IN cord-009571-mygj2nd4 703 40 higher high JJR cord-009571-mygj2nd4 703 41 frequency frequency NN cord-009571-mygj2nd4 703 42 and and CC cord-009571-mygj2nd4 703 43 greater great JJR cord-009571-mygj2nd4 703 44 titer titer NN cord-009571-mygj2nd4 703 45 in in IN cord-009571-mygj2nd4 703 46 SLE SLE NNP cord-009571-mygj2nd4 703 47 patients patient NNS cord-009571-mygj2nd4 703 48 who who WP cord-009571-mygj2nd4 703 49 have have VBP cord-009571-mygj2nd4 703 50 hematologic hematologic JJ cord-009571-mygj2nd4 703 51 abnormalities abnormality NNS cord-009571-mygj2nd4 703 52 . . . cord-009571-mygj2nd4 704 1 Clinical clinical JJ cord-009571-mygj2nd4 704 2 and and CC cord-009571-mygj2nd4 704 3 experimental experimental JJ cord-009571-mygj2nd4 704 4 observations observation NNS cord-009571-mygj2nd4 704 5 indicate indicate VBP cord-009571-mygj2nd4 704 6 that that IN cord-009571-mygj2nd4 704 7 estrogens estrogen NNS cord-009571-mygj2nd4 704 8 may may MD cord-009571-mygj2nd4 704 9 play play VB cord-009571-mygj2nd4 704 10 a a DT cord-009571-mygj2nd4 704 11 part part NN cord-009571-mygj2nd4 704 12 in in IN cord-009571-mygj2nd4 704 13 rheumatoid rheumatoid NN cord-009571-mygj2nd4 704 14 arthritis arthritis NN cord-009571-mygj2nd4 704 15 ( ( -LRB- cord-009571-mygj2nd4 704 16 RA RA NNP cord-009571-mygj2nd4 704 17 ) ) -RRB- cord-009571-mygj2nd4 704 18 and and CC cord-009571-mygj2nd4 704 19 in in IN cord-009571-mygj2nd4 704 20 the the DT cord-009571-mygj2nd4 704 21 regulation regulation NN cord-009571-mygj2nd4 704 22 of of IN cord-009571-mygj2nd4 704 23 immune immune JJ cord-009571-mygj2nd4 704 24 responses response NNS cord-009571-mygj2nd4 704 25 . . . cord-009571-mygj2nd4 705 1 In in IN cord-009571-mygj2nd4 705 2 order order NN cord-009571-mygj2nd4 705 3 to to TO cord-009571-mygj2nd4 705 4 delineate delineate VB cord-009571-mygj2nd4 705 5 this this DT cord-009571-mygj2nd4 705 6 relationship relationship NN cord-009571-mygj2nd4 705 7 , , , cord-009571-mygj2nd4 705 8 the the DT cord-009571-mygj2nd4 705 9 effect effect NN cord-009571-mygj2nd4 705 10 of of IN cord-009571-mygj2nd4 705 11 oophorectomy oophorectomy NN cord-009571-mygj2nd4 705 12 in in IN cord-009571-mygj2nd4 705 13 an an DT cord-009571-mygj2nd4 705 14 experimental experimental JJ cord-009571-mygj2nd4 705 15 immune immune NN cord-009571-mygj2nd4 705 16 synovitis synovitis NN cord-009571-mygj2nd4 705 17 resembling resemble VBG cord-009571-mygj2nd4 705 18 RA RA NNP cord-009571-mygj2nd4 705 19 was be VBD cord-009571-mygj2nd4 705 20 studied study VBN cord-009571-mygj2nd4 705 21 . . . cord-009571-mygj2nd4 706 1 Nineteen nineteen CD cord-009571-mygj2nd4 706 2 adult adult NN cord-009571-mygj2nd4 706 3 female female JJ cord-009571-mygj2nd4 706 4 rabbits rabbit NNS cord-009571-mygj2nd4 706 5 were be VBD cord-009571-mygj2nd4 706 6 sensitized sensitize VBN cord-009571-mygj2nd4 706 7 to to IN cord-009571-mygj2nd4 706 8 homologous homologous JJ cord-009571-mygj2nd4 706 9 IgG igg NN cord-009571-mygj2nd4 706 10 and and CC cord-009571-mygj2nd4 706 11 then then RB cord-009571-mygj2nd4 706 12 randomly randomly RB cord-009571-mygj2nd4 706 13 divided divide VBD cord-009571-mygj2nd4 706 14 into into IN cord-009571-mygj2nd4 706 15 4 4 CD cord-009571-mygj2nd4 706 16 groups group NNS cord-009571-mygj2nd4 706 17 . . . cord-009571-mygj2nd4 707 1 Group group NN cord-009571-mygj2nd4 707 2 I -PRON- PRP cord-009571-mygj2nd4 707 3 ( ( -LRB- cord-009571-mygj2nd4 707 4 6 6 CD cord-009571-mygj2nd4 707 5 ) ) -RRB- cord-009571-mygj2nd4 707 6 underwent undergo VBD cord-009571-mygj2nd4 707 7 oorphorectomy oorphorectomy NN cord-009571-mygj2nd4 707 8 . . . cord-009571-mygj2nd4 708 1 Group group NN cord-009571-mygj2nd4 708 2 I1 i1 NN cord-009571-mygj2nd4 708 3 ( ( -LRB- cord-009571-mygj2nd4 708 4 7 7 CD cord-009571-mygj2nd4 708 5 ) ) -RRB- cord-009571-mygj2nd4 708 6 had have VBD cord-009571-mygj2nd4 708 7 the the DT cord-009571-mygj2nd4 708 8 same same JJ cord-009571-mygj2nd4 708 9 but but CC cord-009571-mygj2nd4 708 10 were be VBD cord-009571-mygj2nd4 708 11 treated treat VBN cord-009571-mygj2nd4 708 12 with with IN cord-009571-mygj2nd4 708 13 1 1 CD cord-009571-mygj2nd4 708 14 mg mg NN cord-009571-mygj2nd4 708 15 of of IN cord-009571-mygj2nd4 708 16 estradiol estradiol NNP cord-009571-mygj2nd4 708 17 intramuscularly intramuscularly RB cord-009571-mygj2nd4 708 18 every every DT cord-009571-mygj2nd4 708 19 other other JJ cord-009571-mygj2nd4 708 20 week week NN cord-009571-mygj2nd4 708 21 . . . cord-009571-mygj2nd4 709 1 Group Group NNP cord-009571-mygj2nd4 709 2 I11 I11 NNP cord-009571-mygj2nd4 709 3 ( ( -LRB- cord-009571-mygj2nd4 709 4 3 3 CD cord-009571-mygj2nd4 709 5 ) ) -RRB- cord-009571-mygj2nd4 709 6 had have VBD cord-009571-mygj2nd4 709 7 a a DT cord-009571-mygj2nd4 709 8 sham sham JJ cord-009571-mygj2nd4 709 9 procedure procedure NN cord-009571-mygj2nd4 709 10 ; ; : cord-009571-mygj2nd4 709 11 Group Group NNP cord-009571-mygj2nd4 709 12 IV IV NNP cord-009571-mygj2nd4 709 13 ( ( -LRB- cord-009571-mygj2nd4 709 14 3 3 CD cord-009571-mygj2nd4 709 15 ) ) -RRB- cord-009571-mygj2nd4 709 16 were be VBD cord-009571-mygj2nd4 709 17 unoperated unoperated JJ cord-009571-mygj2nd4 709 18 controls control NNS cord-009571-mygj2nd4 709 19 . . . cord-009571-mygj2nd4 710 1 An an DT cord-009571-mygj2nd4 710 2 immune immune JJ cord-009571-mygj2nd4 710 3 synovitis synovitis NN cord-009571-mygj2nd4 710 4 was be VBD cord-009571-mygj2nd4 710 5 then then RB cord-009571-mygj2nd4 710 6 induced induce VBN cord-009571-mygj2nd4 710 7 in in IN cord-009571-mygj2nd4 710 8 the the DT cord-009571-mygj2nd4 710 9 right right JJ cord-009571-mygj2nd4 710 10 knee knee NN cord-009571-mygj2nd4 710 11 by by IN cord-009571-mygj2nd4 710 12 the the DT cord-009571-mygj2nd4 710 13 biweekly biweekly JJ cord-009571-mygj2nd4 710 14 intraarticular intraarticular JJ cord-009571-mygj2nd4 710 15 injection injection NN cord-009571-mygj2nd4 710 16 of of IN cord-009571-mygj2nd4 710 17 1 1 CD cord-009571-mygj2nd4 710 18 mg mg NNP cord-009571-mygj2nd4 710 19 of of IN cord-009571-mygj2nd4 710 20 IgG IgG NNP cord-009571-mygj2nd4 710 21 and and CC cord-009571-mygj2nd4 710 22 the the DT cord-009571-mygj2nd4 710 23 animal animal NN cord-009571-mygj2nd4 710 24 sacrificed sacrifice VBD cord-009571-mygj2nd4 710 25 after after IN cord-009571-mygj2nd4 710 26 8 8 CD cord-009571-mygj2nd4 710 27 weeks week NNS cord-009571-mygj2nd4 710 28 . . . cord-009571-mygj2nd4 711 1 Skin skin NN cord-009571-mygj2nd4 711 2 testing testing NN cord-009571-mygj2nd4 711 3 to to IN cord-009571-mygj2nd4 711 4 IgG IgG NNP cord-009571-mygj2nd4 711 5 was be VBD cord-009571-mygj2nd4 711 6 done do VBN cord-009571-mygj2nd4 711 7 at at IN cord-009571-mygj2nd4 711 8 2 2 CD cord-009571-mygj2nd4 711 9 week week NN cord-009571-mygj2nd4 711 10 intervals interval NNS cord-009571-mygj2nd4 711 11 . . . cord-009571-mygj2nd4 712 1 Serum serum NN cord-009571-mygj2nd4 712 2 cortisol cortisol NN cord-009571-mygj2nd4 712 3 levels level NNS cord-009571-mygj2nd4 712 4 were be VBD cord-009571-mygj2nd4 712 5 performed perform VBN cord-009571-mygj2nd4 712 6 prior prior RB cord-009571-mygj2nd4 712 7 to to IN cord-009571-mygj2nd4 712 8 sacrifice sacrifice NN cord-009571-mygj2nd4 712 9 by by IN cord-009571-mygj2nd4 712 10 use use NN cord-009571-mygj2nd4 712 11 of of IN cord-009571-mygj2nd4 712 12 a a DT cord-009571-mygj2nd4 712 13 radioimmunoassay radioimmunoassay JJ cord-009571-mygj2nd4 712 14 technique technique NN cord-009571-mygj2nd4 712 15 . . . cord-009571-mygj2nd4 713 1 Gross gross JJ cord-009571-mygj2nd4 713 2 and and CC cord-009571-mygj2nd4 713 3 histologic histologic JJ cord-009571-mygj2nd4 713 4 assessment assessment NN cord-009571-mygj2nd4 713 5 of of IN cord-009571-mygj2nd4 713 6 synovial synovial JJ cord-009571-mygj2nd4 713 7 inflammation inflammation NN cord-009571-mygj2nd4 713 8 and and CC cord-009571-mygj2nd4 713 9 cartilage cartilage NN cord-009571-mygj2nd4 713 10 changes change NNS cord-009571-mygj2nd4 713 11 was be VBD cord-009571-mygj2nd4 713 12 recorded record VBN cord-009571-mygj2nd4 713 13 using use VBG cord-009571-mygj2nd4 713 14 a a DT cord-009571-mygj2nd4 713 15 " " `` cord-009571-mygj2nd4 713 16 blind blind JJ cord-009571-mygj2nd4 713 17 " " '' cord-009571-mygj2nd4 713 18 grading grading NN cord-009571-mygj2nd4 713 19 previously previously RB cord-009571-mygj2nd4 713 20 reported report VBN cord-009571-mygj2nd4 713 21 from from IN cord-009571-mygj2nd4 713 22 0 0 CD cord-009571-mygj2nd4 713 23 for for IN cord-009571-mygj2nd4 713 24 no no DT cord-009571-mygj2nd4 713 25 changes change NNS cord-009571-mygj2nd4 713 26 to to IN cord-009571-mygj2nd4 713 27 3 3 CD cord-009571-mygj2nd4 713 28 + + CC cord-009571-mygj2nd4 713 29 for for IN cord-009571-mygj2nd4 713 30 severe severe JJ cord-009571-mygj2nd4 713 31 involvement involvement NN cord-009571-mygj2nd4 713 32 . . . cord-009571-mygj2nd4 714 1 Synovial synovial JJ cord-009571-mygj2nd4 714 2 cathepsin cathepsin NN cord-009571-mygj2nd4 714 3 D d NN cord-009571-mygj2nd4 714 4 activity activity NN cord-009571-mygj2nd4 714 5 was be VBD cord-009571-mygj2nd4 714 6 analyzed analyze VBN cord-009571-mygj2nd4 714 7 by by IN cord-009571-mygj2nd4 714 8 the the DT cord-009571-mygj2nd4 714 9 Anson Anson NNP cord-009571-mygj2nd4 714 10 technique technique NN cord-009571-mygj2nd4 714 11 . . . cord-009571-mygj2nd4 715 1 There there EX cord-009571-mygj2nd4 715 2 were be VBD cord-009571-mygj2nd4 715 3 no no DT cord-009571-mygj2nd4 715 4 changes change NNS cord-009571-mygj2nd4 715 5 in in IN cord-009571-mygj2nd4 715 6 the the DT cord-009571-mygj2nd4 715 7 initial initial JJ cord-009571-mygj2nd4 715 8 positive positive JJ cord-009571-mygj2nd4 715 9 skin skin NN cord-009571-mygj2nd4 715 10 tests test NNS cord-009571-mygj2nd4 715 11 to to IN cord-009571-mygj2nd4 715 12 IgG igg NN cord-009571-mygj2nd4 715 13 in in IN cord-009571-mygj2nd4 715 14 any any DT cord-009571-mygj2nd4 715 15 groups group NNS cord-009571-mygj2nd4 715 16 . . . cord-009571-mygj2nd4 716 1 Cortisol cortisol NN cord-009571-mygj2nd4 716 2 levels level NNS cord-009571-mygj2nd4 716 3 in in IN cord-009571-mygj2nd4 716 4 Groups group NNS cord-009571-mygj2nd4 716 5 11,111 11,111 CD cord-009571-mygj2nd4 716 6 , , , cord-009571-mygj2nd4 716 7 and and CC cord-009571-mygj2nd4 716 8 IV IV NNP cord-009571-mygj2nd4 716 9 were be VBD cord-009571-mygj2nd4 716 10 5.06 5.06 CD cord-009571-mygj2nd4 716 11 , , , cord-009571-mygj2nd4 716 12 3.53 3.53 CD cord-009571-mygj2nd4 716 13 , , , cord-009571-mygj2nd4 716 14 3.60 3.60 CD cord-009571-mygj2nd4 716 15 Hg% Hg% NNP cord-009571-mygj2nd4 716 16 without without IN cord-009571-mygj2nd4 716 17 significant significant JJ cord-009571-mygj2nd4 716 18 differences difference NNS cord-009571-mygj2nd4 716 19 , , , cord-009571-mygj2nd4 716 20 while while IN cord-009571-mygj2nd4 716 21 in in IN cord-009571-mygj2nd4 716 22 Group Group NNP cord-009571-mygj2nd4 716 23 I I NNP cord-009571-mygj2nd4 716 24 , , , cord-009571-mygj2nd4 716 25 the the DT cord-009571-mygj2nd4 716 26 1.7 1.7 CD cord-009571-mygj2nd4 716 27 was be VBD cord-009571-mygj2nd4 716 28 significantly significantly RB cord-009571-mygj2nd4 716 29 depressed depressed JJ cord-009571-mygj2nd4 716 30 . . . cord-009571-mygj2nd4 717 1 Synovial synovial JJ cord-009571-mygj2nd4 717 2 inflamation inflamation NN cord-009571-mygj2nd4 717 3 in in IN cord-009571-mygj2nd4 717 4 the the DT cord-009571-mygj2nd4 717 5 oophorectomy oophorectomy NN cord-009571-mygj2nd4 717 6 rabbits rabbit NNS cord-009571-mygj2nd4 717 7 was be VBD cord-009571-mygj2nd4 717 8 1 1 CD cord-009571-mygj2nd4 717 9 + + CD cord-009571-mygj2nd4 717 10 , , , cord-009571-mygj2nd4 717 11 compared compare VBN cord-009571-mygj2nd4 717 12 to to IN cord-009571-mygj2nd4 717 13 the the DT cord-009571-mygj2nd4 717 14 unoperated unoperated JJ cord-009571-mygj2nd4 717 15 and and CC cord-009571-mygj2nd4 717 16 sham sham NN cord-009571-mygj2nd4 717 17 groups group NNS cord-009571-mygj2nd4 717 18 of of IN cord-009571-mygj2nd4 717 19 2 2 CD cord-009571-mygj2nd4 717 20 + + SYM cord-009571-mygj2nd4 717 21 . . . cord-009571-mygj2nd4 718 1 The the DT cord-009571-mygj2nd4 718 2 reduced reduce VBN cord-009571-mygj2nd4 718 3 synovitis synovitis NN cord-009571-mygj2nd4 718 4 in in IN cord-009571-mygj2nd4 718 5 Group Group NNP cord-009571-mygj2nd4 719 1 I -PRON- PRP cord-009571-mygj2nd4 719 2 was be VBD cord-009571-mygj2nd4 719 3 reflected reflect VBN cord-009571-mygj2nd4 719 4 by by IN cord-009571-mygj2nd4 719 5 a a DT cord-009571-mygj2nd4 719 6 significantly significantly RB cord-009571-mygj2nd4 719 7 lower low JJR cord-009571-mygj2nd4 719 8 cathepsin cathepsin NN cord-009571-mygj2nd4 719 9 D d NN cord-009571-mygj2nd4 719 10 level level NN cord-009571-mygj2nd4 719 11 of of IN cord-009571-mygj2nd4 719 12 1.2 1.2 CD cord-009571-mygj2nd4 719 13 p p NN cord-009571-mygj2nd4 719 14 moles mole NNS cord-009571-mygj2nd4 719 15 / / SYM cord-009571-mygj2nd4 719 16 hour hour NN cord-009571-mygj2nd4 719 17 / / SYM cord-009571-mygj2nd4 719 18 l l NN cord-009571-mygj2nd4 719 19 mg mg NNP cord-009571-mygj2nd4 719 20 of of IN cord-009571-mygj2nd4 719 21 protein protein NN cord-009571-mygj2nd4 719 22 compared compare VBN cord-009571-mygj2nd4 719 23 to to IN cord-009571-mygj2nd4 719 24 3.15 3.15 CD cord-009571-mygj2nd4 719 25 and and CC cord-009571-mygj2nd4 719 26 3.06 3.06 CD cord-009571-mygj2nd4 719 27 for for IN cord-009571-mygj2nd4 719 28 the the DT cord-009571-mygj2nd4 719 29 other other JJ cord-009571-mygj2nd4 719 30 groups group NNS cord-009571-mygj2nd4 719 31 . . . cord-009571-mygj2nd4 720 1 However however RB cord-009571-mygj2nd4 720 2 , , , cord-009571-mygj2nd4 720 3 when when WRB cord-009571-mygj2nd4 720 4 oophorectomy oophorectomy NN cord-009571-mygj2nd4 720 5 rabbits rabbit NNS cord-009571-mygj2nd4 720 6 were be VBD cord-009571-mygj2nd4 720 7 given give VBN cord-009571-mygj2nd4 720 8 estrogen estrogen NN cord-009571-mygj2nd4 720 9 replacement replacement NN cord-009571-mygj2nd4 720 10 , , , cord-009571-mygj2nd4 720 11 there there EX cord-009571-mygj2nd4 720 12 was be VBD cord-009571-mygj2nd4 720 13 an an DT cord-009571-mygj2nd4 720 14 increased increase VBN cord-009571-mygj2nd4 720 15 synovitis synovitis NNP cord-009571-mygj2nd4 720 16 rated rate VBN cord-009571-mygj2nd4 720 17 3 3 CD cord-009571-mygj2nd4 720 18 + + CC cord-009571-mygj2nd4 720 19 with with IN cord-009571-mygj2nd4 720 20 a a DT cord-009571-mygj2nd4 720 21 significantly significantly RB cord-009571-mygj2nd4 720 22 elevated elevated JJ cord-009571-mygj2nd4 720 23 cathepsin cathepsin NN cord-009571-mygj2nd4 720 24 D d NN cord-009571-mygj2nd4 720 25 level level NN cord-009571-mygj2nd4 720 26 of of IN cord-009571-mygj2nd4 720 27 5.3 5.3 CD cord-009571-mygj2nd4 720 28 . . . cord-009571-mygj2nd4 721 1 Cartilage cartilage NN cord-009571-mygj2nd4 721 2 changes change NNS cord-009571-mygj2nd4 721 3 were be VBD cord-009571-mygj2nd4 721 4 rated rate VBN cord-009571-mygj2nd4 721 5 2 2 CD cord-009571-mygj2nd4 721 6 + + SYM cord-009571-mygj2nd4 721 7 and and CC cord-009571-mygj2nd4 721 8 appeared appear VBD cord-009571-mygj2nd4 721 9 uniform uniform JJ cord-009571-mygj2nd4 721 10 throughout throughout IN cord-009571-mygj2nd4 721 11 the the DT cord-009571-mygj2nd4 721 12 groups group NNS cord-009571-mygj2nd4 721 13 . . . cord-009571-mygj2nd4 722 1 The the DT cord-009571-mygj2nd4 722 2 results result NNS cord-009571-mygj2nd4 722 3 of of IN cord-009571-mygj2nd4 722 4 this this DT cord-009571-mygj2nd4 722 5 study study NN cord-009571-mygj2nd4 722 6 indicate indicate VBP cord-009571-mygj2nd4 722 7 that that IN cord-009571-mygj2nd4 722 8 in in IN cord-009571-mygj2nd4 722 9 this this DT cord-009571-mygj2nd4 722 10 model model NN cord-009571-mygj2nd4 722 11 of of IN cord-009571-mygj2nd4 722 12 immune immune JJ cord-009571-mygj2nd4 722 13 synovitis synovitis NN cord-009571-mygj2nd4 722 14 , , , cord-009571-mygj2nd4 722 15 oophorectomy oophorectomy NN cord-009571-mygj2nd4 722 16 appeared appear VBD cord-009571-mygj2nd4 722 17 to to TO cord-009571-mygj2nd4 722 18 inhibit inhibit VB cord-009571-mygj2nd4 722 19 synovial synovial JJ cord-009571-mygj2nd4 722 20 inflammation inflammation NN cord-009571-mygj2nd4 722 21 while while IN cord-009571-mygj2nd4 722 22 estrogen estrogen NN cord-009571-mygj2nd4 722 23 replacement replacement NN cord-009571-mygj2nd4 722 24 seemed seem VBD cord-009571-mygj2nd4 722 25 to to TO cord-009571-mygj2nd4 722 26 enhance enhance VB cord-009571-mygj2nd4 722 27 this this DT cord-009571-mygj2nd4 722 28 response response NN cord-009571-mygj2nd4 722 29 . . . cord-009571-mygj2nd4 723 1 Whether whether IN cord-009571-mygj2nd4 723 2 this this DT cord-009571-mygj2nd4 723 3 inhibition inhibition NN cord-009571-mygj2nd4 723 4 is be VBZ cord-009571-mygj2nd4 723 5 by by IN cord-009571-mygj2nd4 723 6 direct direct JJ cord-009571-mygj2nd4 723 7 endocrine endocrine JJ cord-009571-mygj2nd4 723 8 mechanisms mechanism NNS cord-009571-mygj2nd4 723 9 or or CC cord-009571-mygj2nd4 723 10 through through IN cord-009571-mygj2nd4 723 11 the the DT cord-009571-mygj2nd4 723 12 immune immune JJ cord-009571-mygj2nd4 723 13 system system NN cord-009571-mygj2nd4 723 14 remains remain VBZ cord-009571-mygj2nd4 723 15 to to TO cord-009571-mygj2nd4 723 16 be be VB cord-009571-mygj2nd4 723 17 studied study VBN cord-009571-mygj2nd4 723 18 . . . cord-009571-mygj2nd4 724 1 Finally finally RB cord-009571-mygj2nd4 724 2 , , , cord-009571-mygj2nd4 724 3 since since IN cord-009571-mygj2nd4 724 4 RA RA NNP cord-009571-mygj2nd4 724 5 has have VBZ cord-009571-mygj2nd4 724 6 a a DT cord-009571-mygj2nd4 724 7 significant significant JJ cord-009571-mygj2nd4 724 8 female female JJ cord-009571-mygj2nd4 724 9 predilection predilection NN cord-009571-mygj2nd4 724 10 , , , cord-009571-mygj2nd4 724 11 these these DT cord-009571-mygj2nd4 724 12 findings finding NNS cord-009571-mygj2nd4 724 13 may may MD cord-009571-mygj2nd4 724 14 be be VB cord-009571-mygj2nd4 724 15 important important JJ cord-009571-mygj2nd4 724 16 in in IN cord-009571-mygj2nd4 724 17 the the DT cord-009571-mygj2nd4 724 18 pathophysiology pathophysiology NN cord-009571-mygj2nd4 724 19 of of IN cord-009571-mygj2nd4 724 20 this this DT cord-009571-mygj2nd4 724 21 disease disease NN cord-009571-mygj2nd4 724 22 . . . cord-009571-mygj2nd4 725 1 We -PRON- PRP cord-009571-mygj2nd4 725 2 investigated investigate VBD cord-009571-mygj2nd4 725 3 the the DT cord-009571-mygj2nd4 725 4 role role NN cord-009571-mygj2nd4 725 5 of of IN cord-009571-mygj2nd4 725 6 suppressor suppressor NN cord-009571-mygj2nd4 725 7 cells cell NNS cord-009571-mygj2nd4 725 8 in in IN cord-009571-mygj2nd4 725 9 the the DT cord-009571-mygj2nd4 725 10 depressed depressed JJ cord-009571-mygj2nd4 725 11 cellular cellular JJ cord-009571-mygj2nd4 725 12 immunity immunity NN cord-009571-mygj2nd4 725 13 of of IN cord-009571-mygj2nd4 725 14 patients patient NNS cord-009571-mygj2nd4 725 15 with with IN cord-009571-mygj2nd4 725 16 sarcoidosis sarcoidosi NNS cord-009571-mygj2nd4 725 17 . . . cord-009571-mygj2nd4 726 1 We -PRON- PRP cord-009571-mygj2nd4 726 2 have have VBP cord-009571-mygj2nd4 726 3 recently recently RB cord-009571-mygj2nd4 726 4 described describe VBN cord-009571-mygj2nd4 726 5 a a DT cord-009571-mygj2nd4 726 6 glass glass NN cord-009571-mygj2nd4 726 7 adherent adherent JJ cord-009571-mygj2nd4 726 8 prostaglandin prostaglandin NN cord-009571-mygj2nd4 726 9 producing produce VBG cord-009571-mygj2nd4 726 10 suppressor suppressor NN cord-009571-mygj2nd4 726 11 cell cell NN cord-009571-mygj2nd4 726 12 that that WDT cord-009571-mygj2nd4 726 13 inhibits inhibit VBZ cord-009571-mygj2nd4 726 14 T t NN cord-009571-mygj2nd4 726 15 - - HYPH cord-009571-mygj2nd4 726 16 cell cell NN cord-009571-mygj2nd4 726 17 mitogenesis mitogenesis NN cord-009571-mygj2nd4 726 18 in in IN cord-009571-mygj2nd4 726 19 phytohemagglutinin phytohemagglutinin NNP cord-009571-mygj2nd4 726 20 ( ( -LRB- cord-009571-mygj2nd4 726 21 PHA PHA NNP cord-009571-mygj2nd4 726 22 ) ) -RRB- cord-009571-mygj2nd4 726 23 stimulated stimulate VBD cord-009571-mygj2nd4 726 24 cultures culture NNS cord-009571-mygj2nd4 726 25 of of IN cord-009571-mygj2nd4 726 26 human human JJ cord-009571-mygj2nd4 726 27 peripheral peripheral JJ cord-009571-mygj2nd4 726 28 blood blood NN cord-009571-mygj2nd4 726 29 mononuclear mononuclear NN cord-009571-mygj2nd4 726 30 cells cell NNS cord-009571-mygj2nd4 726 31 ( ( -LRB- cord-009571-mygj2nd4 726 32 PBMC PBMC NNP cord-009571-mygj2nd4 726 33 ) ) -RRB- cord-009571-mygj2nd4 726 34 by by IN cord-009571-mygj2nd4 726 35 secreting secrete VBG cord-009571-mygj2nd4 726 36 PGE PGE NNP cord-009571-mygj2nd4 726 37 , , , cord-009571-mygj2nd4 726 38 ( ( -LRB- cord-009571-mygj2nd4 726 39 J J NNP cord-009571-mygj2nd4 726 40 Exp Exp NNP cord-009571-mygj2nd4 726 41 Med Med NNP cord-009571-mygj2nd4 726 42 146:1719 146:1719 NN cord-009571-mygj2nd4 726 43 , , , cord-009571-mygj2nd4 726 44 1977 1977 CD cord-009571-mygj2nd4 726 45 . . . cord-009571-mygj2nd4 727 1 Increased increase VBN cord-009571-mygj2nd4 727 2 activity activity NN cord-009571-mygj2nd4 727 3 of of IN cord-009571-mygj2nd4 727 4 this this DT cord-009571-mygj2nd4 727 5 cell cell NN cord-009571-mygj2nd4 727 6 is be VBZ cord-009571-mygj2nd4 727 7 responsible responsible JJ cord-009571-mygj2nd4 727 8 for for IN cord-009571-mygj2nd4 727 9 the the DT cord-009571-mygj2nd4 727 10 hyporesponsiveness hyporesponsiveness NN cord-009571-mygj2nd4 727 11 to to IN cord-009571-mygj2nd4 727 12 PHA PHA NNP cord-009571-mygj2nd4 727 13 seen see VBN cord-009571-mygj2nd4 727 14 in in IN cord-009571-mygj2nd4 727 15 PBMC PBMC NNS cord-009571-mygj2nd4 727 16 from from IN cord-009571-mygj2nd4 727 17 patients patient NNS cord-009571-mygj2nd4 727 18 with with IN cord-009571-mygj2nd4 727 19 Hodgkin Hodgkin NNP cord-009571-mygj2nd4 727 20 's 's POS cord-009571-mygj2nd4 727 21 disease disease NN cord-009571-mygj2nd4 727 22 ( ( -LRB- cord-009571-mygj2nd4 727 23 N N NNP cord-009571-mygj2nd4 727 24 Engl Engl NNP cord-009571-mygj2nd4 727 25 J J NNP cord-009571-mygj2nd4 727 26 Med Med NNP cord-009571-mygj2nd4 727 27 297:963 297:963 CD cord-009571-mygj2nd4 727 28 , , , cord-009571-mygj2nd4 727 29 The the DT cord-009571-mygj2nd4 727 30 mean mean JJ cord-009571-mygj2nd4 727 31 response response NN cord-009571-mygj2nd4 727 32 of of IN cord-009571-mygj2nd4 727 33 14 14 CD cord-009571-mygj2nd4 727 34 patients patient NNS cord-009571-mygj2nd4 727 35 with with IN cord-009571-mygj2nd4 727 36 active active JJ cord-009571-mygj2nd4 727 37 sarcoidosis sarcoidosi NNS cord-009571-mygj2nd4 727 38 to to IN cord-009571-mygj2nd4 727 39 three three CD cord-009571-mygj2nd4 727 40 concentrations concentration NNS cord-009571-mygj2nd4 727 41 of of IN cord-009571-mygj2nd4 727 42 PHA PHA NNP cord-009571-mygj2nd4 727 43 was be VBD cord-009571-mygj2nd4 727 44 significantly significantly RB cord-009571-mygj2nd4 727 45 ( ( -LRB- cord-009571-mygj2nd4 727 46 P p NN cord-009571-mygj2nd4 727 47 < < XX cord-009571-mygj2nd4 727 48 0.01 0.01 CD cord-009571-mygj2nd4 727 49 ) ) -RRB- cord-009571-mygj2nd4 727 50 less less JJR cord-009571-mygj2nd4 727 51 than than IN cord-009571-mygj2nd4 727 52 controls control NNS cord-009571-mygj2nd4 727 53 . . . cord-009571-mygj2nd4 728 1 Passage passage NN cord-009571-mygj2nd4 728 2 of of IN cord-009571-mygj2nd4 728 3 the the DT cord-009571-mygj2nd4 728 4 cells cell NNS cord-009571-mygj2nd4 728 5 over over IN cord-009571-mygj2nd4 728 6 glass glass NN cord-009571-mygj2nd4 728 7 wool wool NN cord-009571-mygj2nd4 728 8 resulted result VBD cord-009571-mygj2nd4 728 9 in in IN cord-009571-mygj2nd4 728 10 a a DT cord-009571-mygj2nd4 728 11 116 116 CD cord-009571-mygj2nd4 728 12 % % NN cord-009571-mygj2nd4 728 13 increase increase NN cord-009571-mygj2nd4 728 14 in in IN cord-009571-mygj2nd4 728 15 the the DT cord-009571-mygj2nd4 728 16 mean mean JJ cord-009571-mygj2nd4 728 17 response response NN cord-009571-mygj2nd4 728 18 to to IN cord-009571-mygj2nd4 728 19 PHA PHA NNP cord-009571-mygj2nd4 728 20 in in IN cord-009571-mygj2nd4 728 21 the the DT cord-009571-mygj2nd4 728 22 sarcoidosis sarcoidosis NN cord-009571-mygj2nd4 728 23 patients patient NNS cord-009571-mygj2nd4 728 24 and and CC cord-009571-mygj2nd4 728 25 a a DT cord-009571-mygj2nd4 728 26 39 39 CD cord-009571-mygj2nd4 728 27 % % NN cord-009571-mygj2nd4 728 28 decrease decrease NN cord-009571-mygj2nd4 728 29 in in IN cord-009571-mygj2nd4 728 30 controls control NNS cord-009571-mygj2nd4 728 31 . . . cord-009571-mygj2nd4 729 1 The the DT cord-009571-mygj2nd4 729 2 PHA PHA NNP cord-009571-mygj2nd4 729 3 response response NN cord-009571-mygj2nd4 729 4 of of IN cord-009571-mygj2nd4 729 5 the the DT cord-009571-mygj2nd4 729 6 active active JJ cord-009571-mygj2nd4 729 7 sarcoidosis sarcoidosis NN cord-009571-mygj2nd4 729 8 patients patient NNS cord-009571-mygj2nd4 729 9 went go VBD cord-009571-mygj2nd4 729 10 from from IN cord-009571-mygj2nd4 729 11 20 20 CD cord-009571-mygj2nd4 729 12 % % NN cord-009571-mygj2nd4 729 13 of of IN cord-009571-mygj2nd4 729 14 control control NN cord-009571-mygj2nd4 729 15 before before IN cord-009571-mygj2nd4 729 16 passage passage NN cord-009571-mygj2nd4 729 17 over over IN cord-009571-mygj2nd4 729 18 glass glass NN cord-009571-mygj2nd4 729 19 wool wool NN cord-009571-mygj2nd4 729 20 to to IN cord-009571-mygj2nd4 729 21 71 71 CD cord-009571-mygj2nd4 729 22 % % NN cord-009571-mygj2nd4 729 23 of of IN cord-009571-mygj2nd4 729 24 control control NN cord-009571-mygj2nd4 729 25 after after RB cord-009571-mygj2nd4 729 26 . . . cord-009571-mygj2nd4 730 1 Addition addition NN cord-009571-mygj2nd4 730 2 of of IN cord-009571-mygj2nd4 730 3 indomethacin indomethacin NN cord-009571-mygj2nd4 730 4 , , , cord-009571-mygj2nd4 730 5 a a DT cord-009571-mygj2nd4 730 6 prostaglandin prostaglandin NN cord-009571-mygj2nd4 730 7 synthetase synthetase NN cord-009571-mygj2nd4 730 8 inhibitor inhibitor NN cord-009571-mygj2nd4 730 9 , , , cord-009571-mygj2nd4 730 10 to to IN cord-009571-mygj2nd4 730 11 PHA PHA NNP cord-009571-mygj2nd4 730 12 cultures culture NNS cord-009571-mygj2nd4 730 13 increased increase VBD cord-009571-mygj2nd4 730 14 the the DT cord-009571-mygj2nd4 730 15 response response NN cord-009571-mygj2nd4 730 16 of of IN cord-009571-mygj2nd4 730 17 the the DT cord-009571-mygj2nd4 730 18 PBMC PBMC NNP cord-009571-mygj2nd4 730 19 from from IN cord-009571-mygj2nd4 730 20 patients patient NNS cord-009571-mygj2nd4 730 21 with with IN cord-009571-mygj2nd4 730 22 sarcoidosis sarcoidosis NN cord-009571-mygj2nd4 730 23 192 192 CD cord-009571-mygj2nd4 730 24 f f CD cord-009571-mygj2nd4 730 25 32 32 CD cord-009571-mygj2nd4 730 26 % % NN cord-009571-mygj2nd4 730 27 versus versus IN cord-009571-mygj2nd4 730 28 a a DT cord-009571-mygj2nd4 730 29 112 112 CD cord-009571-mygj2nd4 730 30 f f CD cord-009571-mygj2nd4 730 31 18 18 CD cord-009571-mygj2nd4 730 32 % % NN cord-009571-mygj2nd4 730 33 1977 1977 CD cord-009571-mygj2nd4 730 34 ) ) -RRB- cord-009571-mygj2nd4 730 35 . . . cord-009571-mygj2nd4 731 1 increase increase NN cord-009571-mygj2nd4 731 2 in in IN cord-009571-mygj2nd4 731 3 controls control NNS cord-009571-mygj2nd4 731 4 ( ( -LRB- cord-009571-mygj2nd4 731 5 mean mean VB cord-009571-mygj2nd4 731 6 f f NNP cord-009571-mygj2nd4 731 7 SEM SEM NNP cord-009571-mygj2nd4 731 8 , , , cord-009571-mygj2nd4 731 9 P p NN cord-009571-mygj2nd4 731 10 < < XX cord-009571-mygj2nd4 731 11 0.01 0.01 CD cord-009571-mygj2nd4 731 12 ) ) -RRB- cord-009571-mygj2nd4 731 13 . . . cord-009571-mygj2nd4 732 1 The the DT cord-009571-mygj2nd4 732 2 sarcoidosis sarcoidosis NN cord-009571-mygj2nd4 732 3 patients patient NNS cord-009571-mygj2nd4 732 4 had have VBD cord-009571-mygj2nd4 732 5 an an DT cord-009571-mygj2nd4 732 6 increased increase VBN cord-009571-mygj2nd4 732 7 percentage percentage NN cord-009571-mygj2nd4 732 8 of of IN cord-009571-mygj2nd4 732 9 . . . cord-009571-mygj2nd4 733 1 monocytes monocyte NNS cord-009571-mygj2nd4 733 2 in in IN cord-009571-mygj2nd4 733 3 the the DT cord-009571-mygj2nd4 733 4 peripheral peripheral JJ cord-009571-mygj2nd4 733 5 blood blood NN cord-009571-mygj2nd4 733 6 mononucleat mononucleat NNP cord-009571-mygj2nd4 733 7 cell cell NN cord-009571-mygj2nd4 733 8 preparations preparation NNS cord-009571-mygj2nd4 733 9 ( ( -LRB- cord-009571-mygj2nd4 733 10 31 31 CD cord-009571-mygj2nd4 733 11 f f NN cord-009571-mygj2nd4 733 12 5 5 CD cord-009571-mygj2nd4 733 13 % % NN cord-009571-mygj2nd4 733 14 monocytes monocyte NNS cord-009571-mygj2nd4 733 15 for for IN cord-009571-mygj2nd4 733 16 patients patient NNS cord-009571-mygj2nd4 733 17 , , , cord-009571-mygj2nd4 733 18 13 13 CD cord-009571-mygj2nd4 733 19 f f CD cord-009571-mygj2nd4 733 20 2 2 CD cord-009571-mygj2nd4 733 21 % % NN cord-009571-mygj2nd4 733 22 for for IN cord-009571-mygj2nd4 733 23 controls control NNS cord-009571-mygj2nd4 733 24 , , , cord-009571-mygj2nd4 733 25 mean mean VB cord-009571-mygj2nd4 733 26 f f NNP cord-009571-mygj2nd4 733 27 SEM SEM NNP cord-009571-mygj2nd4 733 28 , , , cord-009571-mygj2nd4 733 29 P p NN cord-009571-mygj2nd4 733 30 < < XX cord-009571-mygj2nd4 733 31 0.01 0.01 CD cord-009571-mygj2nd4 733 32 ) ) -RRB- cord-009571-mygj2nd4 733 33 and and CC cord-009571-mygj2nd4 733 34 the the DT cord-009571-mygj2nd4 733 35 percent percent NN cord-009571-mygj2nd4 733 36 monocytes monocyte VBZ cord-009571-mygj2nd4 733 37 in in IN cord-009571-mygj2nd4 733 38 a a DT cord-009571-mygj2nd4 733 39 PBMC PBMC NNP cord-009571-mygj2nd4 733 40 preparation preparation NN cord-009571-mygj2nd4 733 41 from from IN cord-009571-mygj2nd4 733 42 patients patient NNS cord-009571-mygj2nd4 733 43 with with IN cord-009571-mygj2nd4 733 44 active active JJ cord-009571-mygj2nd4 733 45 sarcoidosis sarcoidosis NN cord-009571-mygj2nd4 733 46 correlated correlate VBN cord-009571-mygj2nd4 733 47 with with IN cord-009571-mygj2nd4 733 48 the the DT cord-009571-mygj2nd4 733 49 percent percent NN cord-009571-mygj2nd4 733 50 increase increase NN cord-009571-mygj2nd4 733 51 in in IN cord-009571-mygj2nd4 733 52 PHA PHA NNP cord-009571-mygj2nd4 733 53 response response NN cord-009571-mygj2nd4 733 54 after after IN cord-009571-mygj2nd4 733 55 glass glass NN cord-009571-mygj2nd4 733 56 wool wool NN cord-009571-mygj2nd4 733 57 passage passage NN cord-009571-mygj2nd4 733 58 ( ( -LRB- cord-009571-mygj2nd4 733 59 r r NN cord-009571-mygj2nd4 733 60 = = SYM cord-009571-mygj2nd4 733 61 0.62 0.62 CD cord-009571-mygj2nd4 733 62 , , , cord-009571-mygj2nd4 733 63 P p NN cord-009571-mygj2nd4 733 64 < < XX cord-009571-mygj2nd4 733 65 0.05 0.05 CD cord-009571-mygj2nd4 733 66 ) ) -RRB- cord-009571-mygj2nd4 733 67 . . . cord-009571-mygj2nd4 734 1 Thus thus RB cord-009571-mygj2nd4 734 2 , , , cord-009571-mygj2nd4 734 3 there there EX cord-009571-mygj2nd4 734 4 appear appear VBP cord-009571-mygj2nd4 734 5 to to TO cord-009571-mygj2nd4 734 6 be be VB cord-009571-mygj2nd4 734 7 at at RB cord-009571-mygj2nd4 734 8 least least RBS cord-009571-mygj2nd4 734 9 three three CD cord-009571-mygj2nd4 734 10 mechanisms mechanism NNS cord-009571-mygj2nd4 734 11 operating operate VBG cord-009571-mygj2nd4 734 12 in in IN cord-009571-mygj2nd4 734 13 the the DT cord-009571-mygj2nd4 734 14 depressed depressed JJ cord-009571-mygj2nd4 734 15 PHA PHA NNP cord-009571-mygj2nd4 734 16 response response NN cord-009571-mygj2nd4 734 17 of of IN cord-009571-mygj2nd4 734 18 PBMC PBMC NNP cord-009571-mygj2nd4 734 19 from from IN cord-009571-mygj2nd4 734 20 patients patient NNS cord-009571-mygj2nd4 734 21 with with IN cord-009571-mygj2nd4 734 22 active active JJ cord-009571-mygj2nd4 734 23 sarcoidosis sarcoidosis NN cord-009571-mygj2nd4 734 24 . . . cord-009571-mygj2nd4 735 1 First first RB cord-009571-mygj2nd4 735 2 , , , cord-009571-mygj2nd4 735 3 there there EX cord-009571-mygj2nd4 735 4 appears appear VBZ cord-009571-mygj2nd4 735 5 to to TO cord-009571-mygj2nd4 735 6 be be VB cord-009571-mygj2nd4 735 7 increased increase VBN cord-009571-mygj2nd4 735 8 activity activity NN cord-009571-mygj2nd4 735 9 of of IN cord-009571-mygj2nd4 735 10 the the DT cord-009571-mygj2nd4 735 11 prostaglandin prostaglandin NN cord-009571-mygj2nd4 735 12 producing produce VBG cord-009571-mygj2nd4 735 13 suppressor suppressor NN cord-009571-mygj2nd4 735 14 cell cell NN cord-009571-mygj2nd4 735 15 . . . cord-009571-mygj2nd4 736 1 Second second RB cord-009571-mygj2nd4 736 2 , , , cord-009571-mygj2nd4 736 3 the the DT cord-009571-mygj2nd4 736 4 increased increase VBN cord-009571-mygj2nd4 736 5 proportion proportion NN cord-009571-mygj2nd4 736 6 of of IN cord-009571-mygj2nd4 736 7 monocytes monocyte NNS cord-009571-mygj2nd4 736 8 correlates correlate VBZ cord-009571-mygj2nd4 736 9 with with IN cord-009571-mygj2nd4 736 10 increased increase VBN cord-009571-mygj2nd4 736 11 suppression suppression NN cord-009571-mygj2nd4 736 12 , , , cord-009571-mygj2nd4 736 13 either either CC cord-009571-mygj2nd4 736 14 via via IN cord-009571-mygj2nd4 736 15 a a DT cord-009571-mygj2nd4 736 16 diluting diluting NN cord-009571-mygj2nd4 736 17 effect effect NN cord-009571-mygj2nd4 736 18 or or CC cord-009571-mygj2nd4 736 19 perhaps perhaps RB cord-009571-mygj2nd4 736 20 through through IN cord-009571-mygj2nd4 736 21 another another DT cord-009571-mygj2nd4 736 22 active active JJ cord-009571-mygj2nd4 736 23 suppressive suppressive JJ cord-009571-mygj2nd4 736 24 effect effect NN cord-009571-mygj2nd4 736 25 . . . cord-009571-mygj2nd4 737 1 Blockade blockade NN cord-009571-mygj2nd4 737 2 of of IN cord-009571-mygj2nd4 737 3 these these DT cord-009571-mygj2nd4 737 4 first first JJ cord-009571-mygj2nd4 737 5 two two CD cord-009571-mygj2nd4 737 6 mechanisms mechanism NNS cord-009571-mygj2nd4 737 7 by by IN cord-009571-mygj2nd4 737 8 indomethacin indomethacin NN cord-009571-mygj2nd4 737 9 and and CC cord-009571-mygj2nd4 737 10 glass glass NN cord-009571-mygj2nd4 737 11 wool wool NN cord-009571-mygj2nd4 737 12 passage passage NN cord-009571-mygj2nd4 737 13 does do VBZ cord-009571-mygj2nd4 737 14 not not RB cord-009571-mygj2nd4 737 15 result result VB cord-009571-mygj2nd4 737 16 in in IN cord-009571-mygj2nd4 737 17 total total JJ cord-009571-mygj2nd4 737 18 restoration restoration NN cord-009571-mygj2nd4 737 19 of of IN cord-009571-mygj2nd4 737 20 the the DT cord-009571-mygj2nd4 737 21 PHA PHA NNP cord-009571-mygj2nd4 737 22 response response NN cord-009571-mygj2nd4 737 23 of of IN cord-009571-mygj2nd4 737 24 patients patient NNS cord-009571-mygj2nd4 737 25 with with IN cord-009571-mygj2nd4 737 26 active active JJ cord-009571-mygj2nd4 737 27 sarcoidosis sarcoidosis NN cord-009571-mygj2nd4 737 28 , , , cord-009571-mygj2nd4 737 29 and and CC cord-009571-mygj2nd4 737 30 therefore therefore RB cord-009571-mygj2nd4 737 31 , , , cord-009571-mygj2nd4 737 32 a a DT cord-009571-mygj2nd4 737 33 third third JJ cord-009571-mygj2nd4 737 34 , , , cord-009571-mygj2nd4 737 35 as as RB cord-009571-mygj2nd4 737 36 yet yet RB cord-009571-mygj2nd4 737 37 unknown unknown JJ cord-009571-mygj2nd4 737 38 , , , cord-009571-mygj2nd4 737 39 factor factor NN cord-009571-mygj2nd4 737 40 must must MD cord-009571-mygj2nd4 737 41 also also RB cord-009571-mygj2nd4 737 42 contribute contribute VB cord-009571-mygj2nd4 737 43 to to IN cord-009571-mygj2nd4 737 44 the the DT cord-009571-mygj2nd4 737 45 depressed depressed JJ cord-009571-mygj2nd4 737 46 PHA PHA NNP cord-009571-mygj2nd4 737 47 response response NN cord-009571-mygj2nd4 737 48 . . . cord-009571-mygj2nd4 738 1 The the DT cord-009571-mygj2nd4 738 2 rheumatologist rheumatologist NN cord-009571-mygj2nd4 738 3 is be VBZ cord-009571-mygj2nd4 738 4 aware aware JJ cord-009571-mygj2nd4 738 5 of of IN cord-009571-mygj2nd4 738 6 hand hand NN cord-009571-mygj2nd4 738 7 deformities deformity NNS cord-009571-mygj2nd4 738 8 in in IN cord-009571-mygj2nd4 738 9 the the DT cord-009571-mygj2nd4 738 10 adult adult NN cord-009571-mygj2nd4 738 11 . . . cord-009571-mygj2nd4 739 1 Very very RB cord-009571-mygj2nd4 739 2 little little JJ cord-009571-mygj2nd4 739 3 is be VBZ cord-009571-mygj2nd4 739 4 written write VBN cord-009571-mygj2nd4 739 5 concerning concern VBG cord-009571-mygj2nd4 739 6 the the DT cord-009571-mygj2nd4 739 7 hand hand NN cord-009571-mygj2nd4 739 8 of of IN cord-009571-mygj2nd4 739 9 the the DT cord-009571-mygj2nd4 739 10 child child NN cord-009571-mygj2nd4 739 11 with with IN cord-009571-mygj2nd4 739 12 juvenile juvenile JJ cord-009571-mygj2nd4 739 13 rheumatoid rheumatoid NN cord-009571-mygj2nd4 739 14 arthritis arthritis NN cord-009571-mygj2nd4 739 15 ( ( -LRB- cord-009571-mygj2nd4 739 16 JRA JRA NNP cord-009571-mygj2nd4 739 17 ) ) -RRB- cord-009571-mygj2nd4 739 18 . . . cord-009571-mygj2nd4 740 1 Roentgenographic roentgenographic JJ cord-009571-mygj2nd4 740 2 and and CC cord-009571-mygj2nd4 740 3 clinical clinical JJ cord-009571-mygj2nd4 740 4 analysis analysis NN cord-009571-mygj2nd4 740 5 was be VBD cord-009571-mygj2nd4 740 6 done do VBN cord-009571-mygj2nd4 740 7 , , , cord-009571-mygj2nd4 740 8 review review NN cord-009571-mygj2nd4 740 9 of of IN cord-009571-mygj2nd4 740 10 surgery surgery NN cord-009571-mygj2nd4 740 11 and and CC cord-009571-mygj2nd4 740 12 outline outline NN cord-009571-mygj2nd4 740 13 of of IN cord-009571-mygj2nd4 740 14 treatment treatment NN cord-009571-mygj2nd4 740 15 is be VBZ cord-009571-mygj2nd4 740 16 given give VBN cord-009571-mygj2nd4 740 17 . . . cord-009571-mygj2nd4 741 1 Five five CD cord-009571-mygj2nd4 741 2 - - HYPH cord-009571-mygj2nd4 741 3 hundred hundred CD cord-009571-mygj2nd4 741 4 patients patient NNS cord-009571-mygj2nd4 741 5 are be VBP cord-009571-mygj2nd4 741 6 under under IN cord-009571-mygj2nd4 741 7 treatment treatment NN cord-009571-mygj2nd4 741 8 . . . cord-009571-mygj2nd4 742 1 There there EX cord-009571-mygj2nd4 742 2 are be VBP cord-009571-mygj2nd4 742 3 three three CD cord-009571-mygj2nd4 742 4 basic basic JJ cord-009571-mygj2nd4 742 5 types type NNS cord-009571-mygj2nd4 742 6 of of IN cord-009571-mygj2nd4 742 7 onset onset NN cord-009571-mygj2nd4 742 8 in in IN cord-009571-mygj2nd4 742 9 JRA JRA NNP cord-009571-mygj2nd4 742 10 . . . cord-009571-mygj2nd4 743 1 Systemic systemic JJ cord-009571-mygj2nd4 743 2 onset onset NN cord-009571-mygj2nd4 743 3 is be VBZ cord-009571-mygj2nd4 743 4 similar similar JJ cord-009571-mygj2nd4 743 5 to to IN cord-009571-mygj2nd4 743 6 that that DT cord-009571-mygj2nd4 743 7 described describe VBN cord-009571-mygj2nd4 743 8 by by IN cord-009571-mygj2nd4 743 9 Still still RB cord-009571-mygj2nd4 743 10 ; ; : cord-009571-mygj2nd4 743 11 polyarticular polyarticular JJ cord-009571-mygj2nd4 743 12 closely closely RB cord-009571-mygj2nd4 743 13 resembles resemble VBZ cord-009571-mygj2nd4 743 14 the the DT cord-009571-mygj2nd4 743 15 disease disease NN cord-009571-mygj2nd4 743 16 in in IN cord-009571-mygj2nd4 743 17 the the DT cord-009571-mygj2nd4 743 18 adult adult NN cord-009571-mygj2nd4 743 19 ; ; : cord-009571-mygj2nd4 743 20 pauciarticular pauciarticular NNP cord-009571-mygj2nd4 743 21 involves involve VBZ cord-009571-mygj2nd4 743 22 four four CD cord-009571-mygj2nd4 743 23 or or CC cord-009571-mygj2nd4 743 24 less less JJR cord-009571-mygj2nd4 743 25 joints joint NNS cord-009571-mygj2nd4 743 26 . . . cord-009571-mygj2nd4 744 1 JRA JRA NNP cord-009571-mygj2nd4 744 2 has have VBZ cord-009571-mygj2nd4 744 3 a a DT cord-009571-mygj2nd4 744 4 much much RB cord-009571-mygj2nd4 744 5 better well JJR cord-009571-mygj2nd4 744 6 prognosis prognosis NN cord-009571-mygj2nd4 744 7 than than IN cord-009571-mygj2nd4 744 8 the the DT cord-009571-mygj2nd4 744 9 adult adult NN cord-009571-mygj2nd4 744 10 type type NN cord-009571-mygj2nd4 744 11 but but CC cord-009571-mygj2nd4 744 12 tends tend VBZ cord-009571-mygj2nd4 744 13 to to TO cord-009571-mygj2nd4 744 14 produce produce VB cord-009571-mygj2nd4 744 15 more more JJR cord-009571-mygj2nd4 744 16 stiffness stiffness NN cord-009571-mygj2nd4 744 17 . . . cord-009571-mygj2nd4 745 1 Examination examination NN cord-009571-mygj2nd4 745 2 of of IN cord-009571-mygj2nd4 745 3 100 100 CD cord-009571-mygj2nd4 745 4 successive successive JJ cord-009571-mygj2nd4 745 5 children child NNS cord-009571-mygj2nd4 745 6 showed show VBD cord-009571-mygj2nd4 745 7 10 10 CD cord-009571-mygj2nd4 745 8 % % NN cord-009571-mygj2nd4 745 9 had have VBD cord-009571-mygj2nd4 745 10 radial radial JJ cord-009571-mygj2nd4 745 11 deviation deviation NN cord-009571-mygj2nd4 745 12 of of IN cord-009571-mygj2nd4 745 13 the the DT cord-009571-mygj2nd4 745 14 rnetacarpophalangeal rnetacarpophalangeal NN cord-009571-mygj2nd4 745 15 ( ( -LRB- cord-009571-mygj2nd4 745 16 MCP MCP NNP cord-009571-mygj2nd4 745 17 ) ) -RRB- cord-009571-mygj2nd4 745 18 joint joint NN cord-009571-mygj2nd4 745 19 and and CC cord-009571-mygj2nd4 745 20 23 23 CD cord-009571-mygj2nd4 745 21 % % NN cord-009571-mygj2nd4 745 22 bad bad JJ cord-009571-mygj2nd4 745 23 decreased decrease VBN cord-009571-mygj2nd4 745 24 flexion flexion NN cord-009571-mygj2nd4 745 25 . . . cord-009571-mygj2nd4 746 1 Seven seven CD cord-009571-mygj2nd4 746 2 percent percent NN cord-009571-mygj2nd4 746 3 had have VBD cord-009571-mygj2nd4 746 4 boutonniere boutonniere NN cord-009571-mygj2nd4 746 5 deformity deformity NN cord-009571-mygj2nd4 746 6 and and CC cord-009571-mygj2nd4 746 7 1 1 CD cord-009571-mygj2nd4 746 8 % % NN cord-009571-mygj2nd4 746 9 had have VBD cord-009571-mygj2nd4 746 10 a a DT cord-009571-mygj2nd4 746 11 swan swan NN cord-009571-mygj2nd4 746 12 - - HYPH cord-009571-mygj2nd4 746 13 neck neck NN cord-009571-mygj2nd4 746 14 contracture contracture NN cord-009571-mygj2nd4 746 15 . . . cord-009571-mygj2nd4 747 1 There there EX cord-009571-mygj2nd4 747 2 was be VBD cord-009571-mygj2nd4 747 3 decreased decrease VBN cord-009571-mygj2nd4 747 4 flexion flexion NN cord-009571-mygj2nd4 747 5 of of IN cord-009571-mygj2nd4 747 6 the the DT cord-009571-mygj2nd4 747 7 PIP PIP NNP cord-009571-mygj2nd4 747 8 in in IN cord-009571-mygj2nd4 747 9 27 27 CD cord-009571-mygj2nd4 747 10 % % NN cord-009571-mygj2nd4 747 11 and and CC cord-009571-mygj2nd4 747 12 decreased decrease VBD cord-009571-mygj2nd4 747 13 extension extension NN cord-009571-mygj2nd4 747 14 in in IN cord-009571-mygj2nd4 747 15 10 10 CD cord-009571-mygj2nd4 747 16 % % NN cord-009571-mygj2nd4 747 17 . . . cord-009571-mygj2nd4 748 1 The the DT cord-009571-mygj2nd4 748 2 wrist wrist NN cord-009571-mygj2nd4 748 3 showed show VBD cord-009571-mygj2nd4 748 4 55 55 CD cord-009571-mygj2nd4 748 5 % % NN cord-009571-mygj2nd4 748 6 decreased decrease VBD cord-009571-mygj2nd4 748 7 extension extension NN cord-009571-mygj2nd4 748 8 and and CC cord-009571-mygj2nd4 748 9 only only RB cord-009571-mygj2nd4 748 10 22 22 CD cord-009571-mygj2nd4 748 11 % % NN cord-009571-mygj2nd4 748 12 decreased decrease VBD cord-009571-mygj2nd4 748 13 flexion flexion NN cord-009571-mygj2nd4 748 14 . . . cord-009571-mygj2nd4 749 1 A a DT cord-009571-mygj2nd4 749 2 statistical statistical JJ cord-009571-mygj2nd4 749 3 review review NN cord-009571-mygj2nd4 749 4 of of IN cord-009571-mygj2nd4 749 5 the the DT cord-009571-mygj2nd4 749 6 records record NNS cord-009571-mygj2nd4 749 7 and and CC cord-009571-mygj2nd4 749 8 x x NNS cord-009571-mygj2nd4 749 9 - - NNS cord-009571-mygj2nd4 749 10 rays ray NNS cord-009571-mygj2nd4 749 11 of of IN cord-009571-mygj2nd4 749 12 200 200 CD cord-009571-mygj2nd4 749 13 children child NNS cord-009571-mygj2nd4 749 14 showed show VBD cord-009571-mygj2nd4 749 15 finger finger NN cord-009571-mygj2nd4 749 16 involvement involvement NN cord-009571-mygj2nd4 749 17 in in IN cord-009571-mygj2nd4 749 18 approximately approximately RB cord-009571-mygj2nd4 749 19 50 50 CD cord-009571-mygj2nd4 749 20 % % NN cord-009571-mygj2nd4 749 21 . . . cord-009571-mygj2nd4 750 1 wrist wrist NN cord-009571-mygj2nd4 750 2 involvement involvement NN cord-009571-mygj2nd4 750 3 in in IN cord-009571-mygj2nd4 750 4 approximately approximately RB cord-009571-mygj2nd4 750 5 25 25 CD cord-009571-mygj2nd4 750 6 % % NN cord-009571-mygj2nd4 750 7 , , , cord-009571-mygj2nd4 750 8 and and CC cord-009571-mygj2nd4 750 9 very very RB cord-009571-mygj2nd4 750 10 few few JJ cord-009571-mygj2nd4 750 11 cases case NNS cord-009571-mygj2nd4 750 12 of of IN cord-009571-mygj2nd4 750 13 boutonniere boutonniere NN cord-009571-mygj2nd4 750 14 or or CC cord-009571-mygj2nd4 750 15 swan swan NN cord-009571-mygj2nd4 750 16 - - HYPH cord-009571-mygj2nd4 750 17 neck neck NN cord-009571-mygj2nd4 750 18 . . . cord-009571-mygj2nd4 751 1 Ulnar ulnar JJ cord-009571-mygj2nd4 751 2 shortening shortening NN cord-009571-mygj2nd4 751 3 in in IN cord-009571-mygj2nd4 751 4 93 93 CD cord-009571-mygj2nd4 751 5 joints joint NNS cord-009571-mygj2nd4 751 6 measured measure VBN cord-009571-mygj2nd4 751 7 on on IN cord-009571-mygj2nd4 751 8 roentgenogram roentgenogram NNP cord-009571-mygj2nd4 751 9 showed show VBD cord-009571-mygj2nd4 751 10 a a DT cord-009571-mygj2nd4 751 11 range range NN cord-009571-mygj2nd4 751 12 of of IN cord-009571-mygj2nd4 751 13 1 1 CD cord-009571-mygj2nd4 751 14 - - SYM cord-009571-mygj2nd4 751 15 10 10 CD cord-009571-mygj2nd4 751 16 mm mm NN cord-009571-mygj2nd4 751 17 with with IN cord-009571-mygj2nd4 751 18 an an DT cord-009571-mygj2nd4 751 19 average average NN cord-009571-mygj2nd4 751 20 of of IN cord-009571-mygj2nd4 751 21 4.1 4.1 CD cord-009571-mygj2nd4 751 22 mm mm NNS cord-009571-mygj2nd4 751 23 . . . cord-009571-mygj2nd4 752 1 Ulnar ulnar JJ cord-009571-mygj2nd4 752 2 wrist wrist NN cord-009571-mygj2nd4 752 3 deviation deviation NN cord-009571-mygj2nd4 752 4 was be VBD cord-009571-mygj2nd4 752 5 seen see VBN cord-009571-mygj2nd4 752 6 in in IN cord-009571-mygj2nd4 752 7 67 67 CD cord-009571-mygj2nd4 752 8 joints joint NNS cord-009571-mygj2nd4 752 9 with with IN cord-009571-mygj2nd4 752 10 an an DT cord-009571-mygj2nd4 752 11 average average NN cord-009571-mygj2nd4 752 12 of of IN cord-009571-mygj2nd4 752 13 13 13 CD cord-009571-mygj2nd4 752 14 degrees degree NNS cord-009571-mygj2nd4 752 15 and and CC cord-009571-mygj2nd4 752 16 radial radial JJ cord-009571-mygj2nd4 752 17 deviation deviation NN cord-009571-mygj2nd4 752 18 in in IN cord-009571-mygj2nd4 752 19 12 12 CD cord-009571-mygj2nd4 752 20 joints joint NNS cord-009571-mygj2nd4 752 21 with with IN cord-009571-mygj2nd4 752 22 an an DT cord-009571-mygj2nd4 752 23 average average NN cord-009571-mygj2nd4 752 24 of of IN cord-009571-mygj2nd4 752 25 11 11 CD cord-009571-mygj2nd4 752 26 degrees degree NNS cord-009571-mygj2nd4 752 27 . . . cord-009571-mygj2nd4 753 1 Metacarpophalangeal metacarpophalangeal JJ cord-009571-mygj2nd4 753 2 ulnar ulnar NN cord-009571-mygj2nd4 753 3 deviation deviation NN cord-009571-mygj2nd4 753 4 was be VBD cord-009571-mygj2nd4 753 5 seen see VBN cord-009571-mygj2nd4 753 6 in in IN cord-009571-mygj2nd4 753 7 31 31 CD cord-009571-mygj2nd4 753 8 with with IN cord-009571-mygj2nd4 753 9 a a DT cord-009571-mygj2nd4 753 10 range range NN cord-009571-mygj2nd4 753 11 of of IN cord-009571-mygj2nd4 753 12 2 2 CD cord-009571-mygj2nd4 753 13 to to TO cord-009571-mygj2nd4 753 14 25 25 CD cord-009571-mygj2nd4 753 15 degrees degree NNS cord-009571-mygj2nd4 753 16 and and CC cord-009571-mygj2nd4 753 17 an an DT cord-009571-mygj2nd4 753 18 average average NN cord-009571-mygj2nd4 753 19 of of IN cord-009571-mygj2nd4 753 20 8 8 CD cord-009571-mygj2nd4 753 21 , , , cord-009571-mygj2nd4 753 22 and and CC cord-009571-mygj2nd4 753 23 a a DT cord-009571-mygj2nd4 753 24 MCP MCP NNP cord-009571-mygj2nd4 753 25 radial radial JJ cord-009571-mygj2nd4 753 26 deviation deviation NN cord-009571-mygj2nd4 753 27 also also RB cord-009571-mygj2nd4 753 28 of of IN cord-009571-mygj2nd4 753 29 3 3 CD cord-009571-mygj2nd4 753 30 1 1 CD cord-009571-mygj2nd4 753 31 between between IN cord-009571-mygj2nd4 753 32 2 2 CD cord-009571-mygj2nd4 753 33 and and CC cord-009571-mygj2nd4 753 34 15 15 CD cord-009571-mygj2nd4 753 35 degrees degree NNS cord-009571-mygj2nd4 753 36 with with IN cord-009571-mygj2nd4 753 37 an an DT cord-009571-mygj2nd4 753 38 average average NN cord-009571-mygj2nd4 753 39 of of IN cord-009571-mygj2nd4 753 40 7.4 7.4 CD cord-009571-mygj2nd4 753 41 degrees degree NNS cord-009571-mygj2nd4 753 42 . . . cord-009571-mygj2nd4 754 1 There there EX cord-009571-mygj2nd4 754 2 was be VBD cord-009571-mygj2nd4 755 1 n n CC cord-009571-mygj2nd4 755 2 o o NNP cord-009571-mygj2nd4 755 3 ARA ARA NNP cord-009571-mygj2nd4 755 4 ABSTRACTS ABSTRACTS NNP cord-009571-mygj2nd4 755 5 statistical statistical JJ cord-009571-mygj2nd4 755 6 correlation correlation NN cord-009571-mygj2nd4 755 7 between between IN cord-009571-mygj2nd4 755 8 ulnar ulnar NN cord-009571-mygj2nd4 755 9 shortening shortening NN cord-009571-mygj2nd4 755 10 , , , cord-009571-mygj2nd4 755 11 ulnar ulnar JJ cord-009571-mygj2nd4 755 12 deviation deviation NN cord-009571-mygj2nd4 755 13 , , , cord-009571-mygj2nd4 755 14 and and CC cord-009571-mygj2nd4 755 15 metacarpophalangeal metacarpophalangeal NN cord-009571-mygj2nd4 755 16 radial radial JJ cord-009571-mygj2nd4 755 17 deviation deviation NN cord-009571-mygj2nd4 755 18 , , , cord-009571-mygj2nd4 755 19 as as IN cord-009571-mygj2nd4 755 20 reported report VBN cord-009571-mygj2nd4 755 21 in in IN cord-009571-mygj2nd4 755 22 previous previous JJ cord-009571-mygj2nd4 755 23 literature literature NN cord-009571-mygj2nd4 755 24 . . . cord-009571-mygj2nd4 756 1 Surgery surgery NN cord-009571-mygj2nd4 756 2 between between IN cord-009571-mygj2nd4 756 3 1965 1965 CD cord-009571-mygj2nd4 756 4 and and CC cord-009571-mygj2nd4 756 5 1975 1975 CD cord-009571-mygj2nd4 756 6 was be VBD cord-009571-mygj2nd4 756 7 rare rare JJ cord-009571-mygj2nd4 756 8 and and CC cord-009571-mygj2nd4 756 9 included include VBD cord-009571-mygj2nd4 756 10 collateral collateral JJ cord-009571-mygj2nd4 756 11 ligament ligament NN cord-009571-mygj2nd4 756 12 release release NN cord-009571-mygj2nd4 756 13 in in IN cord-009571-mygj2nd4 756 14 2 2 CD cord-009571-mygj2nd4 756 15 patients patient NNS cord-009571-mygj2nd4 756 16 , , , cord-009571-mygj2nd4 756 17 tenolysis tenolysis NN cord-009571-mygj2nd4 756 18 on on IN cord-009571-mygj2nd4 756 19 5 5 CD cord-009571-mygj2nd4 756 20 occasions occasion NNS cord-009571-mygj2nd4 756 21 , , , cord-009571-mygj2nd4 756 22 carpal carpal NN cord-009571-mygj2nd4 756 23 tunnel tunnel NN cord-009571-mygj2nd4 756 24 release release NN cord-009571-mygj2nd4 756 25 , , , cord-009571-mygj2nd4 756 26 and and CC cord-009571-mygj2nd4 756 27 reconstruction reconstruction NN cord-009571-mygj2nd4 756 28 of of IN cord-009571-mygj2nd4 756 29 thumb thumb NN cord-009571-mygj2nd4 756 30 MCP MCP NNP cord-009571-mygj2nd4 756 31 . . . cord-009571-mygj2nd4 757 1 Terminal terminal JJ cord-009571-mygj2nd4 757 2 vasospasm vasospasm NN cord-009571-mygj2nd4 757 3 required require VBD cord-009571-mygj2nd4 757 4 finger finger NN cord-009571-mygj2nd4 757 5 amputation amputation NN cord-009571-mygj2nd4 757 6 . . . cord-009571-mygj2nd4 758 1 Synovectomy Synovectomy NNP cord-009571-mygj2nd4 758 2 of of IN cord-009571-mygj2nd4 758 3 16 16 CD cord-009571-mygj2nd4 758 4 MCP MCP NNP cord-009571-mygj2nd4 758 5 and and CC cord-009571-mygj2nd4 758 6 10 10 CD cord-009571-mygj2nd4 758 7 PIPjoints pipjoint NNS cord-009571-mygj2nd4 758 8 was be VBD cord-009571-mygj2nd4 758 9 done do VBN cord-009571-mygj2nd4 758 10 and and CC cord-009571-mygj2nd4 758 11 studied study VBN cord-009571-mygj2nd4 758 12 between between IN cord-009571-mygj2nd4 758 13 1965 1965 CD cord-009571-mygj2nd4 758 14 and and CC cord-009571-mygj2nd4 758 15 1970 1970 CD cord-009571-mygj2nd4 758 16 . . . cord-009571-mygj2nd4 759 1 N N NNP cord-009571-mygj2nd4 760 1 o o LS cord-009571-mygj2nd4 760 2 recurrences recurrence NNS cord-009571-mygj2nd4 760 3 were be VBD cord-009571-mygj2nd4 760 4 seen see VBN cord-009571-mygj2nd4 760 5 in in IN cord-009571-mygj2nd4 760 6 late late JJ cord-009571-mygj2nd4 760 7 followup followup NN cord-009571-mygj2nd4 760 8 , , , cord-009571-mygj2nd4 760 9 but but CC cord-009571-mygj2nd4 760 10 stiffness stiffness NN cord-009571-mygj2nd4 760 11 precluded preclude VBD cord-009571-mygj2nd4 760 12 continuing continue VBG cord-009571-mygj2nd4 760 13 this this DT cord-009571-mygj2nd4 760 14 procedure procedure NN cord-009571-mygj2nd4 760 15 . . . cord-009571-mygj2nd4 761 1 The the DT cord-009571-mygj2nd4 761 2 common common JJ cord-009571-mygj2nd4 761 3 problem problem NN cord-009571-mygj2nd4 761 4 of of IN cord-009571-mygj2nd4 761 5 wrist wrist NN cord-009571-mygj2nd4 761 6 flexion flexion NN cord-009571-mygj2nd4 761 7 contracture contracture NN cord-009571-mygj2nd4 761 8 is be VBZ cord-009571-mygj2nd4 761 9 best well RBS cord-009571-mygj2nd4 761 10 managed manage VBN cord-009571-mygj2nd4 761 11 by by IN cord-009571-mygj2nd4 761 12 physical physical JJ cord-009571-mygj2nd4 761 13 therapy therapy NN cord-009571-mygj2nd4 761 14 and and CC cord-009571-mygj2nd4 761 15 extension extension NN cord-009571-mygj2nd4 761 16 orthosis orthosis NN cord-009571-mygj2nd4 761 17 , , , cord-009571-mygj2nd4 761 18 and and CC cord-009571-mygj2nd4 761 19 the the DT cord-009571-mygj2nd4 761 20 loss loss NN cord-009571-mygj2nd4 761 21 of of IN cord-009571-mygj2nd4 761 22 finger finger NN cord-009571-mygj2nd4 761 23 flexion flexion NN cord-009571-mygj2nd4 761 24 by by IN cord-009571-mygj2nd4 761 25 active active JJ cord-009571-mygj2nd4 761 26 exercises exercise NNS cord-009571-mygj2nd4 761 27 , , , cord-009571-mygj2nd4 761 28 occasional occasional JJ cord-009571-mygj2nd4 761 29 injection injection NN cord-009571-mygj2nd4 761 30 , , , cord-009571-mygj2nd4 761 31 and and CC cord-009571-mygj2nd4 761 32 active active JJ cord-009571-mygj2nd4 761 33 splinting splinting NN cord-009571-mygj2nd4 761 34 . . . cord-009571-mygj2nd4 762 1 We -PRON- PRP cord-009571-mygj2nd4 762 2 have have VBP cord-009571-mygj2nd4 762 3 previously previously RB cord-009571-mygj2nd4 762 4 demonstrated demonstrate VBN cord-009571-mygj2nd4 762 5 that that IN cord-009571-mygj2nd4 762 6 the the DT cord-009571-mygj2nd4 762 7 translational translational JJ cord-009571-mygj2nd4 762 8 movement movement NN cord-009571-mygj2nd4 762 9 of of IN cord-009571-mygj2nd4 762 10 glucose glucose NN cord-009571-mygj2nd4 762 11 in in IN cord-009571-mygj2nd4 762 12 pathologic pathologic JJ cord-009571-mygj2nd4 762 13 synovial synovial JJ cord-009571-mygj2nd4 762 14 fluids fluid NNS cord-009571-mygj2nd4 762 15 is be VBZ cord-009571-mygj2nd4 762 16 too too RB cord-009571-mygj2nd4 762 17 rapid rapid JJ cord-009571-mygj2nd4 762 18 to to TO cord-009571-mygj2nd4 762 19 be be VB cord-009571-mygj2nd4 762 20 accounted account VBN cord-009571-mygj2nd4 762 21 for for IN cord-009571-mygj2nd4 762 22 by by IN cord-009571-mygj2nd4 762 23 bulk bulk JJ cord-009571-mygj2nd4 762 24 diffusion diffusion NN cord-009571-mygj2nd4 762 25 ( ( -LRB- cord-009571-mygj2nd4 762 26 Fed Fed NNP cord-009571-mygj2nd4 762 27 Proc Proc NNP cord-009571-mygj2nd4 762 28 36:1069 36:1069 CD cord-009571-mygj2nd4 762 29 , , , cord-009571-mygj2nd4 762 30 1977 1977 CD cord-009571-mygj2nd4 762 31 . . . cord-009571-mygj2nd4 763 1 Such such JJ cord-009571-mygj2nd4 763 2 enhanced enhance VBN cord-009571-mygj2nd4 763 3 diffusivity diffusivity NN cord-009571-mygj2nd4 763 4 is be VBZ cord-009571-mygj2nd4 763 5 a a DT cord-009571-mygj2nd4 763 6 property property NN cord-009571-mygj2nd4 763 7 of of IN cord-009571-mygj2nd4 763 8 a a DT cord-009571-mygj2nd4 763 9 n n RB cord-009571-mygj2nd4 763 10 isolated isolate VBN cord-009571-mygj2nd4 763 11 2.5 2.5 CD cord-009571-mygj2nd4 763 12 % % NN cord-009571-mygj2nd4 763 13 matrix matrix NN cord-009571-mygj2nd4 763 14 of of IN cord-009571-mygj2nd4 763 15 HA HA NNP cord-009571-mygj2nd4 763 16 as as RB cord-009571-mygj2nd4 763 17 well well RB cord-009571-mygj2nd4 763 18 , , , cord-009571-mygj2nd4 763 19 wherein wherein WRB cord-009571-mygj2nd4 763 20 both both CC cord-009571-mygj2nd4 763 21 diffusivity diffusivity NN cord-009571-mygj2nd4 763 22 and and CC cord-009571-mygj2nd4 763 23 matrix matrix NN cord-009571-mygj2nd4 763 24 structure structure NN cord-009571-mygj2nd4 763 25 are be VBP cord-009571-mygj2nd4 763 26 critically critically RB cord-009571-mygj2nd4 763 27 dependent dependent JJ cord-009571-mygj2nd4 763 28 on on IN cord-009571-mygj2nd4 763 29 Ca++ Ca++ NNP cord-009571-mygj2nd4 763 30 concentration concentration NN cord-009571-mygj2nd4 763 31 ( ( -LRB- cord-009571-mygj2nd4 763 32 see see VB cord-009571-mygj2nd4 763 33 Semin Semin NNP cord-009571-mygj2nd4 763 34 Arthritis Arthritis NNP cord-009571-mygj2nd4 763 35 Rheum Rheum NNP cord-009571-mygj2nd4 763 36 7:141 7:141 CD cord-009571-mygj2nd4 763 37 - - SYM cord-009571-mygj2nd4 763 38 152 152 CD cord-009571-mygj2nd4 763 39 , , , cord-009571-mygj2nd4 763 40 1977 1977 CD cord-009571-mygj2nd4 763 41 for for IN cord-009571-mygj2nd4 763 42 review review NN cord-009571-mygj2nd4 763 43 ) ) -RRB- cord-009571-mygj2nd4 763 44 . . . cord-009571-mygj2nd4 764 1 The the DT cord-009571-mygj2nd4 764 2 current current JJ cord-009571-mygj2nd4 764 3 study study NN cord-009571-mygj2nd4 764 4 examines examine VBZ cord-009571-mygj2nd4 764 5 translation translation NN cord-009571-mygj2nd4 764 6 movement movement NN cord-009571-mygj2nd4 764 7 of of IN cord-009571-mygj2nd4 764 8 glucose glucose NN cord-009571-mygj2nd4 764 9 in in IN cord-009571-mygj2nd4 764 10 a a DT cord-009571-mygj2nd4 764 11 I% i% NN cord-009571-mygj2nd4 764 12 matrix matrix NN cord-009571-mygj2nd4 764 13 . . . cord-009571-mygj2nd4 765 1 Human human JJ cord-009571-mygj2nd4 765 2 umbilical umbilical NN cord-009571-mygj2nd4 765 3 H h NN cord-009571-mygj2nd4 765 4 A a NN cord-009571-mygj2nd4 765 5 and and CC cord-009571-mygj2nd4 765 6 agarose agarose JJ cord-009571-mygj2nd4 765 7 were be VBD cord-009571-mygj2nd4 765 8 prepared prepare VBN cord-009571-mygj2nd4 765 9 as as IN cord-009571-mygj2nd4 765 10 1 1 CD cord-009571-mygj2nd4 765 11 % % NN cord-009571-mygj2nd4 765 12 matrices matrix NNS cord-009571-mygj2nd4 765 13 in in IN cord-009571-mygj2nd4 765 14 phosphate phosphate NN cord-009571-mygj2nd4 765 15 buffered buffer VBN cord-009571-mygj2nd4 765 16 saline saline NN cord-009571-mygj2nd4 765 17 at at IN cord-009571-mygj2nd4 765 18 pH pH NNP cord-009571-mygj2nd4 765 19 7.0 7.0 CD cord-009571-mygj2nd4 765 20 . . . cord-009571-mygj2nd4 766 1 The the DT cord-009571-mygj2nd4 766 2 bulk bulk JJ cord-009571-mygj2nd4 766 3 diffusion diffusion NN cord-009571-mygj2nd4 766 4 coefficients coefficient NNS cord-009571-mygj2nd4 766 5 ( ( -LRB- cord-009571-mygj2nd4 766 6 D D NNP cord-009571-mygj2nd4 766 7 ) ) -RRB- cord-009571-mygj2nd4 766 8 for for IN cord-009571-mygj2nd4 766 9 glucose glucose NN cord-009571-mygj2nd4 766 10 and and CC cord-009571-mygj2nd4 766 11 sucrose sucrose NN cord-009571-mygj2nd4 766 12 within within IN cord-009571-mygj2nd4 766 13 each each DT cord-009571-mygj2nd4 766 14 matrix matrix NN cord-009571-mygj2nd4 766 15 were be VBD cord-009571-mygj2nd4 766 16 determined determine VBN cord-009571-mygj2nd4 766 17 in in IN cord-009571-mygj2nd4 766 18 codiffusion codiffusion NN cord-009571-mygj2nd4 766 19 experiments experiment NNS cord-009571-mygj2nd4 766 20 employing employ VBG cord-009571-mygj2nd4 766 21 a a DT cord-009571-mygj2nd4 766 22 capillary capillary JJ cord-009571-mygj2nd4 766 23 method method NN cord-009571-mygj2nd4 766 24 . . . cord-009571-mygj2nd4 767 1 The the DT cord-009571-mygj2nd4 767 2 D d NN cord-009571-mygj2nd4 767 3 for for IN cord-009571-mygj2nd4 767 4 both both DT cord-009571-mygj2nd4 767 5 solutes solute NNS cord-009571-mygj2nd4 767 6 in in IN cord-009571-mygj2nd4 767 7 H H NNP cord-009571-mygj2nd4 767 8 A A NNP cord-009571-mygj2nd4 767 9 was be VBD cord-009571-mygj2nd4 767 10 indistinguishable indistinguishable JJ cord-009571-mygj2nd4 767 11 from from IN cord-009571-mygj2nd4 767 12 that that DT cord-009571-mygj2nd4 767 13 in in IN cord-009571-mygj2nd4 767 14 agarose agarose NN cord-009571-mygj2nd4 767 15 . . . cord-009571-mygj2nd4 768 1 If if IN cord-009571-mygj2nd4 768 2 the the DT cord-009571-mygj2nd4 768 3 matrix matrix NN cord-009571-mygj2nd4 768 4 was be VBD cord-009571-mygj2nd4 768 5 prepared prepare VBN cord-009571-mygj2nd4 768 6 in in IN cord-009571-mygj2nd4 768 7 50 50 CD cord-009571-mygj2nd4 768 8 % % NN cord-009571-mygj2nd4 768 9 horse horse NN cord-009571-mygj2nd4 768 10 serum serum NN cord-009571-mygj2nd4 768 11 , , , cord-009571-mygj2nd4 768 12 glucose glucose NN cord-009571-mygj2nd4 768 13 diffusivity diffusivity NN cord-009571-mygj2nd4 768 14 was be VBD cord-009571-mygj2nd4 768 15 enhanced enhance VBN cord-009571-mygj2nd4 768 16 twofold twofold RB cord-009571-mygj2nd4 768 17 in in IN cord-009571-mygj2nd4 768 18 H H NNP cord-009571-mygj2nd4 768 19 A A NNP cord-009571-mygj2nd4 768 20 while while NN cord-009571-mygj2nd4 768 21 slightly slightly RB cord-009571-mygj2nd4 768 22 diminished diminish VBN cord-009571-mygj2nd4 768 23 in in IN cord-009571-mygj2nd4 768 24 agarose agarose NN cord-009571-mygj2nd4 768 25 . . . cord-009571-mygj2nd4 769 1 A a DT cord-009571-mygj2nd4 769 2 50 50 CD cord-009571-mygj2nd4 769 3 % % NN cord-009571-mygj2nd4 769 4 dialysate dialysate NN cord-009571-mygj2nd4 769 5 of of IN cord-009571-mygj2nd4 769 6 serum serum NN cord-009571-mygj2nd4 769 7 as as IN cord-009571-mygj2nd4 769 8 a a DT cord-009571-mygj2nd4 769 9 solvent solvent NN cord-009571-mygj2nd4 769 10 enhanced enhance VBD cord-009571-mygj2nd4 769 11 glucose glucose NN cord-009571-mygj2nd4 769 12 diffusivity diffusivity NN cord-009571-mygj2nd4 769 13 in in IN cord-009571-mygj2nd4 769 14 HA HA NNP cord-009571-mygj2nd4 769 15 threefold threefold RB cord-009571-mygj2nd4 769 16 ; ; : cord-009571-mygj2nd4 769 17 the the DT cord-009571-mygj2nd4 769 18 dialyzed dialyzed NNP cord-009571-mygj2nd4 769 19 protein protein NN cord-009571-mygj2nd4 769 20 had have VBD cord-009571-mygj2nd4 769 21 little little JJ cord-009571-mygj2nd4 769 22 effect effect NN cord-009571-mygj2nd4 769 23 . . . cord-009571-mygj2nd4 770 1 The the DT cord-009571-mygj2nd4 770 2 en en JJ cord-009571-mygj2nd4 770 3 - - JJ cord-009571-mygj2nd4 770 4 hanced hanced JJ cord-009571-mygj2nd4 770 5 glucose glucose NN cord-009571-mygj2nd4 770 6 diffusivity diffusivity NN cord-009571-mygj2nd4 770 7 in in IN cord-009571-mygj2nd4 770 8 the the DT cord-009571-mygj2nd4 770 9 presence presence NN cord-009571-mygj2nd4 770 10 of of IN cord-009571-mygj2nd4 770 11 a a DT cord-009571-mygj2nd4 770 12 50 50 CD cord-009571-mygj2nd4 770 13 % % NN cord-009571-mygj2nd4 770 14 dialysate dialysate NN cord-009571-mygj2nd4 770 15 was be VBD cord-009571-mygj2nd4 770 16 inversely inversely RB cord-009571-mygj2nd4 770 17 dependent dependent JJ cord-009571-mygj2nd4 770 18 on on IN cord-009571-mygj2nd4 770 19 solute solute NN cord-009571-mygj2nd4 770 20 concentration concentration NN cord-009571-mygj2nd4 770 21 . . . cord-009571-mygj2nd4 771 1 The the DT cord-009571-mygj2nd4 771 2 diffusivity diffusivity NN cord-009571-mygj2nd4 771 3 of of IN cord-009571-mygj2nd4 771 4 sucrose sucrose NN cord-009571-mygj2nd4 771 5 in in IN cord-009571-mygj2nd4 771 6 H H NNP cord-009571-mygj2nd4 771 7 A A NNP cord-009571-mygj2nd4 771 8 was be VBD cord-009571-mygj2nd4 771 9 little little RB cord-009571-mygj2nd4 771 10 altered alter VBN cord-009571-mygj2nd4 771 11 by by IN cord-009571-mygj2nd4 771 12 these these DT cord-009571-mygj2nd4 771 13 solvent solvent NN cord-009571-mygj2nd4 771 14 changes change NNS cord-009571-mygj2nd4 771 15 . . . cord-009571-mygj2nd4 772 1 In in IN cord-009571-mygj2nd4 772 2 order order NN cord-009571-mygj2nd4 772 3 t t NN cord-009571-mygj2nd4 772 4 o o NN cord-009571-mygj2nd4 772 5 gain gain VB cord-009571-mygj2nd4 772 6 insights insight NNS cord-009571-mygj2nd4 772 7 into into IN cord-009571-mygj2nd4 772 8 matrix matrix NN cord-009571-mygj2nd4 772 9 structure structure NN cord-009571-mygj2nd4 772 10 that that WDT cord-009571-mygj2nd4 772 11 might may MD cord-009571-mygj2nd4 772 12 underlie underlie VB cord-009571-mygj2nd4 772 13 the the DT cord-009571-mygj2nd4 772 14 enhanced enhance VBN cord-009571-mygj2nd4 772 15 glucose glucose NN cord-009571-mygj2nd4 772 16 diffusivity diffusivity NN cord-009571-mygj2nd4 772 17 , , , cord-009571-mygj2nd4 772 18 Darcy Darcy NNP cord-009571-mygj2nd4 772 19 numbers number NNS cord-009571-mygj2nd4 772 20 were be VBD cord-009571-mygj2nd4 772 21 determined determine VBN cord-009571-mygj2nd4 772 22 . . . cord-009571-mygj2nd4 773 1 Permeability permeability NN cord-009571-mygj2nd4 773 2 is be VBZ cord-009571-mygj2nd4 773 3 dependent dependent JJ cord-009571-mygj2nd4 773 4 on on IN cord-009571-mygj2nd4 773 5 H h NN cord-009571-mygj2nd4 773 6 A A NNP cord-009571-mygj2nd4 773 7 concentration concentration NN cord-009571-mygj2nd4 773 8 , , , cord-009571-mygj2nd4 773 9 has have VBZ cord-009571-mygj2nd4 773 10 a a DT cord-009571-mygj2nd4 773 11 pH pH NNP cord-009571-mygj2nd4 773 12 optima optima NNP cord-009571-mygj2nd4 773 13 of of IN cord-009571-mygj2nd4 773 14 7.0 7.0 CD cord-009571-mygj2nd4 773 15 in in IN cord-009571-mygj2nd4 773 16 a a DT cord-009571-mygj2nd4 773 17 1 1 CD cord-009571-mygj2nd4 773 18 % % NN cord-009571-mygj2nd4 773 19 matrix matrix NN cord-009571-mygj2nd4 773 20 , , , cord-009571-mygj2nd4 773 21 and and CC cord-009571-mygj2nd4 773 22 is be VBZ cord-009571-mygj2nd4 773 23 critically critically RB cord-009571-mygj2nd4 773 24 dependent dependent JJ cord-009571-mygj2nd4 773 25 on on IN cord-009571-mygj2nd4 773 26 Ca+ Ca+ NNPS cord-009571-mygj2nd4 773 27 + + CC cord-009571-mygj2nd4 773 28 concentration concentration NN cord-009571-mygj2nd4 773 29 rising rise VBG cord-009571-mygj2nd4 773 30 rapidly rapidly RB cord-009571-mygj2nd4 773 31 below below IN cord-009571-mygj2nd4 773 32 10 10 CD cord-009571-mygj2nd4 773 33 mM. mM. NNP cord-009571-mygj2nd4 773 34 Matrix Matrix NNP cord-009571-mygj2nd4 773 35 structure structure NN cord-009571-mygj2nd4 773 36 is be VBZ cord-009571-mygj2nd4 773 37 highly highly RB cord-009571-mygj2nd4 773 38 dependent dependent JJ cord-009571-mygj2nd4 773 39 on on IN cord-009571-mygj2nd4 773 40 the the DT cord-009571-mygj2nd4 773 41 solvent solvent NN cord-009571-mygj2nd4 773 42 environment environment NN cord-009571-mygj2nd4 773 43 particularly particularly RB cord-009571-mygj2nd4 773 44 in in IN cord-009571-mygj2nd4 773 45 the the DT cord-009571-mygj2nd4 773 46 physiological physiological JJ cord-009571-mygj2nd4 773 47 range range NN cord-009571-mygj2nd4 773 48 . . . cord-009571-mygj2nd4 774 1 Constituents constituent NNS cord-009571-mygj2nd4 774 2 in in IN cord-009571-mygj2nd4 774 3 the the DT cord-009571-mygj2nd4 774 4 serum serum NN cord-009571-mygj2nd4 774 5 dialysate dialysate NN cord-009571-mygj2nd4 774 6 may may MD cord-009571-mygj2nd4 774 7 induce induce VB cord-009571-mygj2nd4 774 8 a a DT cord-009571-mygj2nd4 774 9 matrix matrix NN cord-009571-mygj2nd4 774 10 configuration configuration NN cord-009571-mygj2nd4 774 11 that that WDT cord-009571-mygj2nd4 774 12 supports support VBZ cord-009571-mygj2nd4 774 13 the the DT cord-009571-mygj2nd4 774 14 enhanced enhance VBN cord-009571-mygj2nd4 774 15 glucose glucose NN cord-009571-mygj2nd4 774 16 diffusivity diffusivity NN cord-009571-mygj2nd4 774 17 . . . cord-009571-mygj2nd4 775 1 The the DT cord-009571-mygj2nd4 775 2 matrix matrix NN cord-009571-mygj2nd4 775 3 configuration configuration NN cord-009571-mygj2nd4 775 4 that that WDT cord-009571-mygj2nd4 775 5 exists exist VBZ cord-009571-mygj2nd4 775 6 in in IN cord-009571-mygj2nd4 775 7 the the DT cord-009571-mygj2nd4 775 8 presence presence NN cord-009571-mygj2nd4 775 9 of of IN cord-009571-mygj2nd4 775 10 the the DT cord-009571-mygj2nd4 775 11 dialysate dialysate NN cord-009571-mygj2nd4 775 12 is be VBZ cord-009571-mygj2nd4 775 13 likely likely JJ cord-009571-mygj2nd4 775 14 to to TO cord-009571-mygj2nd4 775 15 be be VB cord-009571-mygj2nd4 775 16 present present JJ cord-009571-mygj2nd4 775 17 in in IN cord-009571-mygj2nd4 775 18 synovial synovial JJ cord-009571-mygj2nd4 775 19 fluid fluid NN cord-009571-mygj2nd4 775 20 as as RB cord-009571-mygj2nd4 775 21 well well RB cord-009571-mygj2nd4 775 22 . . . cord-009571-mygj2nd4 776 1 This this DT cord-009571-mygj2nd4 776 2 configuration configuration NN cord-009571-mygj2nd4 776 3 can can MD cord-009571-mygj2nd4 776 4 facilitate facilitate VB cord-009571-mygj2nd4 776 5 the the DT cord-009571-mygj2nd4 776 6 translational translational JJ cord-009571-mygj2nd4 776 7 movement movement NN cord-009571-mygj2nd4 776 8 of of IN cord-009571-mygj2nd4 776 9 a a DT cord-009571-mygj2nd4 776 10 nutrient nutrient NN cord-009571-mygj2nd4 776 11 such such JJ cord-009571-mygj2nd4 776 12 as as IN cord-009571-mygj2nd4 776 13 glucose glucose NN cord-009571-mygj2nd4 776 14 . . . cord-009571-mygj2nd4 777 1 Facilitated facilitate VBN cord-009571-mygj2nd4 777 2 movement movement NN cord-009571-mygj2nd4 777 3 may may MD cord-009571-mygj2nd4 777 4 be be VB cord-009571-mygj2nd4 777 5 homeostatic homeostatic JJ cord-009571-mygj2nd4 777 6 in in IN cord-009571-mygj2nd4 777 7 inflammatory inflammatory JJ cord-009571-mygj2nd4 777 8 states state NNS cord-009571-mygj2nd4 777 9 such such JJ cord-009571-mygj2nd4 777 10 as as IN cord-009571-mygj2nd4 777 11 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 777 12 arthritis arthritis NN cord-009571-mygj2nd4 777 13 where where WRB cord-009571-mygj2nd4 777 14 low low JJ cord-009571-mygj2nd4 777 15 synovial synovial JJ cord-009571-mygj2nd4 777 16 fluid fluid NN cord-009571-mygj2nd4 777 17 glucose glucose NN cord-009571-mygj2nd4 777 18 concentrations concentration NNS cord-009571-mygj2nd4 777 19 are be VBP cord-009571-mygj2nd4 777 20 well well RB cord-009571-mygj2nd4 777 21 described describe VBN cord-009571-mygj2nd4 777 22 . . . cord-009571-mygj2nd4 778 1 Sera Sera NNP cord-009571-mygj2nd4 778 2 from from IN cord-009571-mygj2nd4 778 3 19 19 CD cord-009571-mygj2nd4 778 4 patients patient NNS cord-009571-mygj2nd4 778 5 with with IN cord-009571-mygj2nd4 778 6 MCTD MCTD NNP cord-009571-mygj2nd4 778 7 were be VBD cord-009571-mygj2nd4 778 8 examined examine VBN cord-009571-mygj2nd4 778 9 for for IN cord-009571-mygj2nd4 778 10 the the DT cord-009571-mygj2nd4 778 11 presence presence NN cord-009571-mygj2nd4 778 12 of of IN cord-009571-mygj2nd4 778 13 immune immune JJ cord-009571-mygj2nd4 778 14 complexes complex NNS cord-009571-mygj2nd4 778 15 ( ( -LRB- cord-009571-mygj2nd4 778 16 IC IC NNP cord-009571-mygj2nd4 778 17 ) ) -RRB- cord-009571-mygj2nd4 778 18 . . . cord-009571-mygj2nd4 779 1 The the DT cord-009571-mygj2nd4 779 2 diagnosis diagnosis NN cord-009571-mygj2nd4 779 3 was be VBD cord-009571-mygj2nd4 779 4 based base VBN cord-009571-mygj2nd4 779 5 on on IN cord-009571-mygj2nd4 779 6 serologic serologic JJ cord-009571-mygj2nd4 779 7 and and CC cord-009571-mygj2nd4 779 8 clinical clinical JJ cord-009571-mygj2nd4 779 9 criteria criterion NNS cord-009571-mygj2nd4 779 10 . . . cord-009571-mygj2nd4 780 1 All all DT cord-009571-mygj2nd4 780 2 patients patient NNS cord-009571-mygj2nd4 780 3 had have VBD cord-009571-mygj2nd4 780 4 antibodies antibody NNS cord-009571-mygj2nd4 780 5 to to IN cord-009571-mygj2nd4 780 6 extractable extractable JJ cord-009571-mygj2nd4 780 7 nuclear nuclear JJ cord-009571-mygj2nd4 780 8 antigen antigen NN cord-009571-mygj2nd4 780 9 by by IN cord-009571-mygj2nd4 780 10 passive passive JJ cord-009571-mygj2nd4 780 11 hemagglutination hemagglutination NN cord-009571-mygj2nd4 780 12 . . . cord-009571-mygj2nd4 781 1 Titers Titers NNP cord-009571-mygj2nd4 781 2 of of IN cord-009571-mygj2nd4 781 3 1 1 CD cord-009571-mygj2nd4 781 4 : : SYM cord-009571-mygj2nd4 781 5 1,000,000 1,000,000 CD cord-009571-mygj2nd4 781 6 or or CC cord-009571-mygj2nd4 781 7 greater great JJR cord-009571-mygj2nd4 781 8 were be VBD cord-009571-mygj2nd4 781 9 found find VBN cord-009571-mygj2nd4 781 10 in in IN cord-009571-mygj2nd4 781 11 17 17 CD cord-009571-mygj2nd4 781 12 patients patient NNS cord-009571-mygj2nd4 781 13 and and CC cord-009571-mygj2nd4 781 14 1:655,OOO 1:655,ooo CD cord-009571-mygj2nd4 781 15 and and CC cord-009571-mygj2nd4 781 16 1 1 CD cord-009571-mygj2nd4 781 17 : : SYM cord-009571-mygj2nd4 781 18 40,960 40,960 CD cord-009571-mygj2nd4 781 19 in in IN cord-009571-mygj2nd4 781 20 the the DT cord-009571-mygj2nd4 781 21 remaining remain VBG cord-009571-mygj2nd4 781 22 two two CD cord-009571-mygj2nd4 781 23 . . . cord-009571-mygj2nd4 782 1 Treatment treatment NN cord-009571-mygj2nd4 782 2 of of IN cord-009571-mygj2nd4 782 3 the the DT cord-009571-mygj2nd4 782 4 antigen antigen NN cord-009571-mygj2nd4 782 5 with with IN cord-009571-mygj2nd4 782 6 RNAse RNAse NNP cord-009571-mygj2nd4 782 7 resulted result VBD cord-009571-mygj2nd4 782 8 in in IN cord-009571-mygj2nd4 782 9 a a DT cord-009571-mygj2nd4 782 10 1,000-fold 1,000-fold CD cord-009571-mygj2nd4 782 11 or or CC cord-009571-mygj2nd4 782 12 greater great JJR cord-009571-mygj2nd4 782 13 decrease decrease NN cord-009571-mygj2nd4 782 14 in in IN cord-009571-mygj2nd4 782 15 titer titer NN cord-009571-mygj2nd4 782 16 in in IN cord-009571-mygj2nd4 782 17 18 18 CD cord-009571-mygj2nd4 782 18 patients patient NNS cord-009571-mygj2nd4 782 19 and and CC cord-009571-mygj2nd4 782 20 a a DT cord-009571-mygj2nd4 782 21 64-fold 64-fold CD cord-009571-mygj2nd4 782 22 decrease decrease NN cord-009571-mygj2nd4 782 23 in in IN cord-009571-mygj2nd4 782 24 one one CD cord-009571-mygj2nd4 782 25 . . . cord-009571-mygj2nd4 783 1 Rheumatoid rheumatoid JJ cord-009571-mygj2nd4 783 2 factors factor NNS cord-009571-mygj2nd4 783 3 were be VBD cord-009571-mygj2nd4 783 4 present present JJ cord-009571-mygj2nd4 783 5 in in IN cord-009571-mygj2nd4 783 6 8 8 CD cord-009571-mygj2nd4 783 7 patients patient NNS cord-009571-mygj2nd4 783 8 and and CC cord-009571-mygj2nd4 783 9 antinuclear antinuclear JJ cord-009571-mygj2nd4 783 10 antibodies antibody NNS cord-009571-mygj2nd4 783 11 in in IN cord-009571-mygj2nd4 783 12 12 12 CD cord-009571-mygj2nd4 783 13 . . . cord-009571-mygj2nd4 784 1 All all DT cord-009571-mygj2nd4 784 2 patients patient NNS cord-009571-mygj2nd4 784 3 had have VBD cord-009571-mygj2nd4 784 4 a a DT cord-009571-mygj2nd4 784 5 mixed mixed JJ cord-009571-mygj2nd4 784 6 rheumatic rheumatic JJ cord-009571-mygj2nd4 784 7 syndrome syndrome NN cord-009571-mygj2nd4 784 8 . . . cord-009571-mygj2nd4 785 1 Clinical clinical JJ cord-009571-mygj2nd4 785 2 features feature NNS cord-009571-mygj2nd4 785 3 included include VBD cord-009571-mygj2nd4 785 4 : : : cord-009571-mygj2nd4 785 5 Raynaud Raynaud NNP cord-009571-mygj2nd4 785 6 's 's POS cord-009571-mygj2nd4 785 7 phenomenon-16 phenomenon-16 NN cord-009571-mygj2nd4 785 8 , , , cord-009571-mygj2nd4 785 9 swollen swollen JJ cord-009571-mygj2nd4 785 10 hands hand NNS cord-009571-mygj2nd4 785 11 and/or and/or CC cord-009571-mygj2nd4 785 12 sclerodactyly-12 sclerodactyly-12 NNP cord-009571-mygj2nd4 785 13 , , , cord-009571-mygj2nd4 786 1 myopathy-1 myopathy-1 NNP cord-009571-mygj2nd4 787 1 I -PRON- PRP cord-009571-mygj2nd4 787 2 , , , cord-009571-mygj2nd4 787 3 pleuritis--12 pleuritis--12 FW cord-009571-mygj2nd4 787 4 , , , cord-009571-mygj2nd4 787 5 malar malar NNP cord-009571-mygj2nd4 787 6 or or CC cord-009571-mygj2nd4 787 7 diffuse diffuse VB cord-009571-mygj2nd4 787 8 rash-7 rash-7 NNP cord-009571-mygj2nd4 787 9 , , , cord-009571-mygj2nd4 787 10 and and CC cord-009571-mygj2nd4 787 11 arthritis-15 arthritis-15 NN cord-009571-mygj2nd4 787 12 . . . cord-009571-mygj2nd4 788 1 One one CD cord-009571-mygj2nd4 788 2 patient patient NN cord-009571-mygj2nd4 788 3 had have VBD cord-009571-mygj2nd4 788 4 a a DT cord-009571-mygj2nd4 788 5 stable stable JJ cord-009571-mygj2nd4 788 6 IgA IgA NNP cord-009571-mygj2nd4 788 7 membranous membranous JJ cord-009571-mygj2nd4 788 8 glomerulopathy glomerulopathy NNP cord-009571-mygj2nd4 788 9 . . . cord-009571-mygj2nd4 789 1 IC IC NNP cord-009571-mygj2nd4 789 2 were be VBD cord-009571-mygj2nd4 789 3 measured measure VBN cord-009571-mygj2nd4 789 4 in in IN cord-009571-mygj2nd4 789 5 46 46 CD cord-009571-mygj2nd4 789 6 sera serum NNS cord-009571-mygj2nd4 789 7 by by IN cord-009571-mygj2nd4 789 8 a a DT cord-009571-mygj2nd4 789 9 Raji Raji NNP cord-009571-mygj2nd4 789 10 cell cell NN cord-009571-mygj2nd4 789 11 radioassay radioassay NN cord-009571-mygj2nd4 789 12 ( ( -LRB- cord-009571-mygj2nd4 789 13 RC RC NNP cord-009571-mygj2nd4 789 14 - - HYPH cord-009571-mygj2nd4 789 15 RA RA NNP cord-009571-mygj2nd4 789 16 ) ) -RRB- cord-009571-mygj2nd4 789 17 , , , cord-009571-mygj2nd4 789 18 monoclonal monoclonal JJ cord-009571-mygj2nd4 789 19 rheumatoid rheumatoid NN cord-009571-mygj2nd4 789 20 factor factor NN cord-009571-mygj2nd4 789 21 radioimmunoassay radioimmunoassay JJ cord-009571-mygj2nd4 789 22 ( ( -LRB- cord-009571-mygj2nd4 789 23 MRF MRF NNP cord-009571-mygj2nd4 789 24 - - HYPH cord-009571-mygj2nd4 789 25 RIA RIA NNP cord-009571-mygj2nd4 789 26 ) ) -RRB- cord-009571-mygj2nd4 789 27 , , , cord-009571-mygj2nd4 789 28 and and CC cord-009571-mygj2nd4 789 29 Clq Clq NNP cord-009571-mygj2nd4 789 30 binding bind VBG cord-009571-mygj2nd4 789 31 assay assay NN cord-009571-mygj2nd4 789 32 ( ( -LRB- cord-009571-mygj2nd4 789 33 Clq Clq NNP cord-009571-mygj2nd4 789 34 - - HYPH cord-009571-mygj2nd4 789 35 BA BA NNP cord-009571-mygj2nd4 789 36 ) ) -RRB- cord-009571-mygj2nd4 789 37 . . . cord-009571-mygj2nd4 790 1 IC IC NNP cord-009571-mygj2nd4 790 2 were be VBD cord-009571-mygj2nd4 790 3 detected detect VBN cord-009571-mygj2nd4 790 4 by by IN cord-009571-mygj2nd4 790 5 at at RB cord-009571-mygj2nd4 790 6 least least RBS cord-009571-mygj2nd4 790 7 one one CD cord-009571-mygj2nd4 790 8 method method NN cord-009571-mygj2nd4 790 9 in in IN cord-009571-mygj2nd4 790 10 45 45 CD cord-009571-mygj2nd4 790 11 ( ( -LRB- cord-009571-mygj2nd4 790 12 98 98 CD cord-009571-mygj2nd4 790 13 % % NN cord-009571-mygj2nd4 790 14 ) ) -RRB- cord-009571-mygj2nd4 790 15 sera sera NNP cord-009571-mygj2nd4 790 16 . . . cord-009571-mygj2nd4 791 1 The the DT cord-009571-mygj2nd4 791 2 single single JJ cord-009571-mygj2nd4 791 3 negative negative JJ cord-009571-mygj2nd4 791 4 serum serum NN cord-009571-mygj2nd4 791 5 was be VBD cord-009571-mygj2nd4 791 6 from from IN cord-009571-mygj2nd4 791 7 a a DT cord-009571-mygj2nd4 791 8 patient patient NN cord-009571-mygj2nd4 791 9 with with IN cord-009571-mygj2nd4 791 10 clinically clinically RB cord-009571-mygj2nd4 791 11 inactive inactive JJ cord-009571-mygj2nd4 791 12 disease disease NN cord-009571-mygj2nd4 791 13 . . . cord-009571-mygj2nd4 792 1 IC IC NNP cord-009571-mygj2nd4 792 2 were be VBD cord-009571-mygj2nd4 792 3 found find VBN cord-009571-mygj2nd4 792 4 by by IN cord-009571-mygj2nd4 792 5 the the DT cord-009571-mygj2nd4 792 6 RC RC NNP cord-009571-mygj2nd4 792 7 - - HYPH cord-009571-mygj2nd4 792 8 RA RA NNP cord-009571-mygj2nd4 792 9 in in IN cord-009571-mygj2nd4 792 10 42 42 CD cord-009571-mygj2nd4 792 11 ( ( -LRB- cord-009571-mygj2nd4 792 12 91 91 CD cord-009571-mygj2nd4 792 13 % % NN cord-009571-mygj2nd4 792 14 ) ) -RRB- cord-009571-mygj2nd4 792 15 sera sera NNP cord-009571-mygj2nd4 792 16 , , , cord-009571-mygj2nd4 792 17 by by IN cord-009571-mygj2nd4 792 18 MRF MRF NNP cord-009571-mygj2nd4 792 19 - - HYPH cord-009571-mygj2nd4 792 20 RIA RIA NNP cord-009571-mygj2nd4 792 21 in in IN cord-009571-mygj2nd4 792 22 22 22 CD cord-009571-mygj2nd4 792 23 ( ( -LRB- cord-009571-mygj2nd4 792 24 48 48 CD cord-009571-mygj2nd4 792 25 % % NN cord-009571-mygj2nd4 792 26 ) ) -RRB- cord-009571-mygj2nd4 792 27 , , , cord-009571-mygj2nd4 792 28 and and CC cord-009571-mygj2nd4 792 29 by by IN cord-009571-mygj2nd4 792 30 Clq Clq NNP cord-009571-mygj2nd4 792 31 - - HYPH cord-009571-mygj2nd4 792 32 BA BA NNP cord-009571-mygj2nd4 792 33 in in IN cord-009571-mygj2nd4 792 34 20 20 CD cord-009571-mygj2nd4 792 35 ( ( -LRB- cord-009571-mygj2nd4 792 36 43 43 CD cord-009571-mygj2nd4 792 37 % % NN cord-009571-mygj2nd4 792 38 ) ) -RRB- cord-009571-mygj2nd4 792 39 . . . cord-009571-mygj2nd4 793 1 Mean mean JJ cord-009571-mygj2nd4 793 2 values value NNS cord-009571-mygj2nd4 793 3 for for IN cord-009571-mygj2nd4 793 4 each each DT cord-009571-mygj2nd4 793 5 assay assay NN cord-009571-mygj2nd4 793 6 compared compare VBN cord-009571-mygj2nd4 793 7 to to IN cord-009571-mygj2nd4 793 8 normal normal JJ cord-009571-mygj2nd4 793 9 controls control NNS cord-009571-mygj2nd4 793 10 were be VBD cord-009571-mygj2nd4 793 11 : : : cord-009571-mygj2nd4 793 12 76.8 76.8 CD cord-009571-mygj2nd4 793 13 versus versus IN cord-009571-mygj2nd4 793 14 1.7 1.7 CD cord-009571-mygj2nd4 793 15 pg pg NNP cord-009571-mygj2nd4 793 16 agg.-IgG agg.-IgG NNP cord-009571-mygj2nd4 793 17 equiv equiv NNP cord-009571-mygj2nd4 793 18 / / SYM cord-009571-mygj2nd4 793 19 ml ml NN cord-009571-mygj2nd4 793 20 for for IN cord-009571-mygj2nd4 793 21 the the DT cord-009571-mygj2nd4 793 22 RC RC NNP cord-009571-mygj2nd4 793 23 - - HYPH cord-009571-mygj2nd4 793 24 RA RA NNP cord-009571-mygj2nd4 793 25 ( ( -LRB- cord-009571-mygj2nd4 793 26 P p NN cord-009571-mygj2nd4 793 27 < < XX cord-009571-mygj2nd4 793 28 0.001 0.001 CD cord-009571-mygj2nd4 793 29 ) ) -RRB- cord-009571-mygj2nd4 793 30 ; ; : cord-009571-mygj2nd4 793 31 12.0 12.0 CD cord-009571-mygj2nd4 793 32 versus versus IN cord-009571-mygj2nd4 793 33 4.4 4.4 CD cord-009571-mygj2nd4 793 34 pg pg NNP cord-009571-mygj2nd4 793 35 agg.-IgG agg.-IgG NNP cord-009571-mygj2nd4 793 36 equiv equiv NNP cord-009571-mygj2nd4 793 37 / / SYM cord-009571-mygj2nd4 793 38 ml ml NN cord-009571-mygj2nd4 793 39 for for IN cord-009571-mygj2nd4 793 40 the the DT cord-009571-mygj2nd4 793 41 MRF MRF NNP cord-009571-mygj2nd4 793 42 - - HYPH cord-009571-mygj2nd4 793 43 RIA RIA NNP cord-009571-mygj2nd4 793 44 ( ( -LRB- cord-009571-mygj2nd4 793 45 P p NN cord-009571-mygj2nd4 793 46 < < XX cord-009571-mygj2nd4 793 47 0.001 0.001 CD cord-009571-mygj2nd4 793 48 ) ) -RRB- cord-009571-mygj2nd4 793 49 ; ; : cord-009571-mygj2nd4 793 50 19.2 19.2 CD cord-009571-mygj2nd4 793 51 % % NN cord-009571-mygj2nd4 793 52 versus versus IN cord-009571-mygj2nd4 793 53 10.9 10.9 CD cord-009571-mygj2nd4 793 54 % % NN cord-009571-mygj2nd4 793 55 la51-Clq la51-Clq NNPS cord-009571-mygj2nd4 793 56 bound bind VBN cord-009571-mygj2nd4 793 57 for for IN cord-009571-mygj2nd4 793 58 the the DT cord-009571-mygj2nd4 793 59 Clq Clq NNP cord-009571-mygj2nd4 793 60 - - HYPH cord-009571-mygj2nd4 793 61 BA BA NNP cord-009571-mygj2nd4 793 62 ( ( -LRB- cord-009571-mygj2nd4 793 63 P p NN cord-009571-mygj2nd4 793 64 < < XX cord-009571-mygj2nd4 793 65 0.001 0.001 CD cord-009571-mygj2nd4 793 66 ) ) -RRB- cord-009571-mygj2nd4 793 67 . . . cord-009571-mygj2nd4 794 1 IC IC NNP cord-009571-mygj2nd4 794 2 were be VBD cord-009571-mygj2nd4 794 3 detected detect VBN cord-009571-mygj2nd4 794 4 by by IN cord-009571-mygj2nd4 794 5 all all DT cord-009571-mygj2nd4 794 6 three three CD cord-009571-mygj2nd4 794 7 assays assay NNS cord-009571-mygj2nd4 794 8 in in IN cord-009571-mygj2nd4 794 9 9 9 CD cord-009571-mygj2nd4 794 10 ( ( -LRB- cord-009571-mygj2nd4 794 11 20 20 CD cord-009571-mygj2nd4 794 12 % % NN cord-009571-mygj2nd4 794 13 ) ) -RRB- cord-009571-mygj2nd4 794 14 sera sera NNP cord-009571-mygj2nd4 794 15 and and CC cord-009571-mygj2nd4 794 16 by by IN cord-009571-mygj2nd4 794 17 two two CD cord-009571-mygj2nd4 794 18 methods method NNS cord-009571-mygj2nd4 794 19 in in IN cord-009571-mygj2nd4 794 20 2 2 CD cord-009571-mygj2nd4 794 21 1 1 CD cord-009571-mygj2nd4 794 22 ( ( -LRB- cord-009571-mygj2nd4 794 23 46 46 CD cord-009571-mygj2nd4 794 24 % % NN cord-009571-mygj2nd4 794 25 ) ) -RRB- cord-009571-mygj2nd4 794 26 . . . cord-009571-mygj2nd4 795 1 Thus thus RB cord-009571-mygj2nd4 795 2 , , , cord-009571-mygj2nd4 795 3 IC IC NNP cord-009571-mygj2nd4 795 4 were be VBD cord-009571-mygj2nd4 795 5 found find VBN cord-009571-mygj2nd4 795 6 by by IN cord-009571-mygj2nd4 795 7 two two CD cord-009571-mygj2nd4 795 8 or or CC cord-009571-mygj2nd4 795 9 more more JJR cord-009571-mygj2nd4 795 10 methods method NNS cord-009571-mygj2nd4 795 11 in in IN cord-009571-mygj2nd4 795 12 30 30 CD cord-009571-mygj2nd4 795 13 ( ( -LRB- cord-009571-mygj2nd4 795 14 65 65 CD cord-009571-mygj2nd4 795 15 ) ) -RRB- cord-009571-mygj2nd4 795 16 sera sera NNP cord-009571-mygj2nd4 795 17 . . . cord-009571-mygj2nd4 796 1 Only only RB cord-009571-mygj2nd4 796 2 three three CD cord-009571-mygj2nd4 796 3 sera sera NNP cord-009571-mygj2nd4 796 4 failed fail VBD cord-009571-mygj2nd4 796 5 to to TO cord-009571-mygj2nd4 796 6 react react VB cord-009571-mygj2nd4 796 7 in in IN cord-009571-mygj2nd4 796 8 more more JJR cord-009571-mygj2nd4 796 9 than than IN cord-009571-mygj2nd4 796 10 one one CD cord-009571-mygj2nd4 796 11 assay assay NN cord-009571-mygj2nd4 796 12 . . . cord-009571-mygj2nd4 797 1 A a DT cord-009571-mygj2nd4 797 2 different different JJ cord-009571-mygj2nd4 797 3 pattern pattern NN cord-009571-mygj2nd4 797 4 of of IN cord-009571-mygj2nd4 797 5 reactivity reactivity NN cord-009571-mygj2nd4 797 6 was be VBD cord-009571-mygj2nd4 797 7 found find VBN cord-009571-mygj2nd4 797 8 in in IN cord-009571-mygj2nd4 797 9 89 89 CD cord-009571-mygj2nd4 797 10 rheumatoid rheumatoid NN cord-009571-mygj2nd4 797 11 arthritis arthritis NN cord-009571-mygj2nd4 797 12 sera sera NNP cord-009571-mygj2nd4 797 13 where where WRB cord-009571-mygj2nd4 797 14 IC IC NNP cord-009571-mygj2nd4 797 15 were be VBD cord-009571-mygj2nd4 797 16 detected detect VBN cord-009571-mygj2nd4 797 17 at at IN cord-009571-mygj2nd4 797 18 a a DT cord-009571-mygj2nd4 797 19 higher high JJR cord-009571-mygj2nd4 797 20 frequency frequency NN cord-009571-mygj2nd4 797 21 by by IN cord-009571-mygj2nd4 797 22 MRF MRF NNP cord-009571-mygj2nd4 797 23 - - HYPH cord-009571-mygj2nd4 797 24 RIA RIA NNP cord-009571-mygj2nd4 797 25 ( ( -LRB- cord-009571-mygj2nd4 797 26 71 71 CD cord-009571-mygj2nd4 797 27 % % NN cord-009571-mygj2nd4 797 28 ) ) -RRB- cord-009571-mygj2nd4 797 29 and and CC cord-009571-mygj2nd4 797 30 Clq Clq NNP cord-009571-mygj2nd4 797 31 - - HYPH cord-009571-mygj2nd4 797 32 BA BA NNP cord-009571-mygj2nd4 797 33 ( ( -LRB- cord-009571-mygj2nd4 797 34 82 82 CD cord-009571-mygj2nd4 797 35 % % NN cord-009571-mygj2nd4 797 36 ) ) -RRB- cord-009571-mygj2nd4 797 37 while while IN cord-009571-mygj2nd4 797 38 the the DT cord-009571-mygj2nd4 797 39 frequency frequency NN cord-009571-mygj2nd4 797 40 by by IN cord-009571-mygj2nd4 797 41 RC RC NNP cord-009571-mygj2nd4 797 42 - - HYPH cord-009571-mygj2nd4 797 43 RA RA NNP cord-009571-mygj2nd4 797 44 ( ( -LRB- cord-009571-mygj2nd4 797 45 28 28 CD cord-009571-mygj2nd4 797 46 % % NN cord-009571-mygj2nd4 797 47 ) ) -RRB- cord-009571-mygj2nd4 797 48 was be VBD cord-009571-mygj2nd4 797 49 lower low JJR cord-009571-mygj2nd4 797 50 . . . cord-009571-mygj2nd4 798 1 Sufficient sufficient JJ cord-009571-mygj2nd4 798 2 clinical clinical JJ cord-009571-mygj2nd4 798 3 data datum NNS cord-009571-mygj2nd4 798 4 were be VBD cord-009571-mygj2nd4 798 5 available available JJ cord-009571-mygj2nd4 798 6 for for IN cord-009571-mygj2nd4 798 7 16 16 CD cord-009571-mygj2nd4 798 8 of of IN cord-009571-mygj2nd4 798 9 the the DT cord-009571-mygj2nd4 798 10 MCTD MCTD NNP cord-009571-mygj2nd4 798 11 patients patient NNS cord-009571-mygj2nd4 798 12 to to TO cord-009571-mygj2nd4 798 13 permit permit VB cord-009571-mygj2nd4 798 14 preliminary preliminary JJ cord-009571-mygj2nd4 798 15 evaluation evaluation NN cord-009571-mygj2nd4 798 16 of of IN cord-009571-mygj2nd4 798 17 the the DT cord-009571-mygj2nd4 798 18 relationship relationship NN cord-009571-mygj2nd4 798 19 of of IN cord-009571-mygj2nd4 798 20 disease disease NN cord-009571-mygj2nd4 798 21 activity activity NN cord-009571-mygj2nd4 798 22 and and CC cord-009571-mygj2nd4 798 23 IC IC NNP cord-009571-mygj2nd4 798 24 . . . cord-009571-mygj2nd4 799 1 Changes change NNS cord-009571-mygj2nd4 799 2 in in IN cord-009571-mygj2nd4 799 3 levels level NNS cord-009571-mygj2nd4 799 4 of of IN cord-009571-mygj2nd4 799 5 IC IC NNP cord-009571-mygj2nd4 799 6 appeared appear VBD cord-009571-mygj2nd4 799 7 to to TO cord-009571-mygj2nd4 799 8 parallel parallel VB cord-009571-mygj2nd4 799 9 clinical clinical JJ cord-009571-mygj2nd4 799 10 activity activity NN cord-009571-mygj2nd4 799 11 in in IN cord-009571-mygj2nd4 799 12 12 12 CD cord-009571-mygj2nd4 799 13 patients patient NNS cord-009571-mygj2nd4 799 14 by by IN cord-009571-mygj2nd4 799 15 RC RC NNP cord-009571-mygj2nd4 799 16 - - HYPH cord-009571-mygj2nd4 799 17 RA RA NNP cord-009571-mygj2nd4 799 18 , , , cord-009571-mygj2nd4 799 19 in in IN cord-009571-mygj2nd4 799 20 9 9 CD cord-009571-mygj2nd4 799 21 by by IN cord-009571-mygj2nd4 799 22 MRF MRF NNP cord-009571-mygj2nd4 799 23 - - HYPH cord-009571-mygj2nd4 799 24 RIA RIA NNP cord-009571-mygj2nd4 799 25 , , , cord-009571-mygj2nd4 799 26 and and CC cord-009571-mygj2nd4 799 27 in in IN cord-009571-mygj2nd4 799 28 3 3 CD cord-009571-mygj2nd4 799 29 by by IN cord-009571-mygj2nd4 799 30 Clq Clq NNP cord-009571-mygj2nd4 799 31 - - HYPH cord-009571-mygj2nd4 799 32 BA BA NNP cord-009571-mygj2nd4 799 33 . . . cord-009571-mygj2nd4 800 1 These these DT cord-009571-mygj2nd4 800 2 data datum NNS cord-009571-mygj2nd4 800 3 indicating indicate VBG cord-009571-mygj2nd4 800 4 a a DT cord-009571-mygj2nd4 800 5 high high JJ cord-009571-mygj2nd4 800 6 incidence incidence NN cord-009571-mygj2nd4 800 7 of of IN cord-009571-mygj2nd4 800 8 IC IC NNP cord-009571-mygj2nd4 800 9 in in IN cord-009571-mygj2nd4 800 10 MCTD MCTD NNP cord-009571-mygj2nd4 800 11 and and CC cord-009571-mygj2nd4 800 12 a a DT cord-009571-mygj2nd4 800 13 different different JJ cord-009571-mygj2nd4 800 14 pattern pattern NN cord-009571-mygj2nd4 800 15 of of IN cord-009571-mygj2nd4 800 16 reactivity reactivity NN cord-009571-mygj2nd4 800 17 from from IN cord-009571-mygj2nd4 800 18 RA RA NNP cord-009571-mygj2nd4 800 19 emphasize emphasize VBP cord-009571-mygj2nd4 800 20 the the DT cord-009571-mygj2nd4 800 21 wide wide JJ cord-009571-mygj2nd4 800 22 spectrum spectrum NN cord-009571-mygj2nd4 800 23 of of IN cord-009571-mygj2nd4 800 24 immune immune JJ cord-009571-mygj2nd4 800 25 complex complex JJ cord-009571-mygj2nd4 800 26 disease disease NN cord-009571-mygj2nd4 800 27 . . . cord-009571-mygj2nd4 801 1 Hydroxyapatite Hydroxyapatite NNP cord-009571-mygj2nd4 801 2 ( ( -LRB- cord-009571-mygj2nd4 801 3 HA HA NNP cord-009571-mygj2nd4 801 4 ) ) -RRB- cord-009571-mygj2nd4 801 5 has have VBZ cord-009571-mygj2nd4 801 6 been be VBN cord-009571-mygj2nd4 801 7 found find VBN cord-009571-mygj2nd4 801 8 by by IN cord-009571-mygj2nd4 801 9 others other NNS cord-009571-mygj2nd4 801 10 in in IN cord-009571-mygj2nd4 801 11 synovial synovial JJ cord-009571-mygj2nd4 801 12 fluid fluid NN cord-009571-mygj2nd4 801 13 and and CC cord-009571-mygj2nd4 801 14 fluid fluid JJ cord-009571-mygj2nd4 801 15 leukocytes leukocyte NNS cord-009571-mygj2nd4 801 16 by by IN cord-009571-mygj2nd4 801 17 electron electron NN cord-009571-mygj2nd4 801 18 microscopy microscopy NN cord-009571-mygj2nd4 801 19 and and CC cord-009571-mygj2nd4 801 20 electron electron NN cord-009571-mygj2nd4 801 21 probe probe NN cord-009571-mygj2nd4 801 22 . . . cord-009571-mygj2nd4 802 1 We -PRON- PRP cord-009571-mygj2nd4 802 2 have have VBP cord-009571-mygj2nd4 802 3 developed develop VBN cord-009571-mygj2nd4 802 4 a a DT cord-009571-mygj2nd4 802 5 method method NN cord-009571-mygj2nd4 802 6 to to TO cord-009571-mygj2nd4 802 7 quantify quantify VB cord-009571-mygj2nd4 802 8 HA HA NNP cord-009571-mygj2nd4 802 9 in in IN cord-009571-mygj2nd4 802 10 synovial synovial JJ cord-009571-mygj2nd4 802 11 fluid fluid NN cord-009571-mygj2nd4 802 12 which which WDT cord-009571-mygj2nd4 802 13 avoids avoid VBZ cord-009571-mygj2nd4 802 14 possible possible JJ cord-009571-mygj2nd4 802 15 EM EM NNP cord-009571-mygj2nd4 802 16 artifacts artifact NNS cord-009571-mygj2nd4 802 17 . . . cord-009571-mygj2nd4 803 1 ( ( -LRB- cord-009571-mygj2nd4 803 2 " " `` cord-009571-mygj2nd4 803 3 C C NNP cord-009571-mygj2nd4 803 4 ) ) -RRB- cord-009571-mygj2nd4 803 5 EHDP EHDP NNP cord-009571-mygj2nd4 803 6 , , , cord-009571-mygj2nd4 803 7 ( ( -LRB- cord-009571-mygj2nd4 803 8 SA SA NNP cord-009571-mygj2nd4 803 9 10.6 10.6 CD cord-009571-mygj2nd4 803 10 pCi pCi NNP cord-009571-mygj2nd4 803 11 / / SYM cord-009571-mygj2nd4 803 12 omole omole NNP cord-009571-mygj2nd4 803 13 ) ) -RRB- cord-009571-mygj2nd4 803 14 was be VBD cord-009571-mygj2nd4 803 15 used use VBN cord-009571-mygj2nd4 803 16 in in IN cord-009571-mygj2nd4 803 17 a a DT cord-009571-mygj2nd4 803 18 final final JJ cord-009571-mygj2nd4 803 19 concentraion concentraion NN cord-009571-mygj2nd4 803 20 of of IN cord-009571-mygj2nd4 803 21 16 16 CD cord-009571-mygj2nd4 803 22 nM nM NNP cord-009571-mygj2nd4 803 23 / / SYM cord-009571-mygj2nd4 803 24 ml ml XX cord-009571-mygj2nd4 803 25 in in IN cord-009571-mygj2nd4 803 26 normal normal JJ cord-009571-mygj2nd4 803 27 serum serum NN cord-009571-mygj2nd4 803 28 or or CC cord-009571-mygj2nd4 803 29 phosphate phosphate NN cord-009571-mygj2nd4 803 30 buffered buffer VBN cord-009571-mygj2nd4 803 31 saline saline NN cord-009571-mygj2nd4 803 32 ( ( -LRB- cord-009571-mygj2nd4 803 33 PBS PBS NNP cord-009571-mygj2nd4 803 34 ) ) -RRB- cord-009571-mygj2nd4 803 35 containing contain VBG cord-009571-mygj2nd4 803 36 standard standard JJ cord-009571-mygj2nd4 803 37 HA HA NNP cord-009571-mygj2nd4 803 38 or or CC cord-009571-mygj2nd4 803 39 to to IN cord-009571-mygj2nd4 803 40 joint joint JJ cord-009571-mygj2nd4 803 41 fluid fluid JJ cord-009571-mygj2nd4 803 42 samples sample NNS cord-009571-mygj2nd4 803 43 ; ; : cord-009571-mygj2nd4 803 44 serum serum NN cord-009571-mygj2nd4 803 45 or or CC cord-009571-mygj2nd4 803 46 joint joint JJ cord-009571-mygj2nd4 803 47 fluids fluid NNS cord-009571-mygj2nd4 803 48 were be VBD cord-009571-mygj2nd4 803 49 processed process VBN cord-009571-mygj2nd4 803 50 under under IN cord-009571-mygj2nd4 803 51 oil oil NN cord-009571-mygj2nd4 803 52 . . . cord-009571-mygj2nd4 804 1 After after IN cord-009571-mygj2nd4 804 2 rotation rotation NN cord-009571-mygj2nd4 804 3 X x NN cord-009571-mygj2nd4 804 4 3h 3h CD cord-009571-mygj2nd4 804 5 4"C 4"c CD cord-009571-mygj2nd4 804 6 , , , cord-009571-mygj2nd4 804 7 radioactivity radioactivity NN cord-009571-mygj2nd4 804 8 / / SYM cord-009571-mygj2nd4 804 9 O.l O.l NNP cord-009571-mygj2nd4 804 10 ml ml NNP cord-009571-mygj2nd4 804 11 was be VBD cord-009571-mygj2nd4 804 12 determined determine VBN cord-009571-mygj2nd4 804 13 before before IN cord-009571-mygj2nd4 804 14 and and CC cord-009571-mygj2nd4 804 15 after after IN cord-009571-mygj2nd4 804 16 centrifugation centrifugation NN cord-009571-mygj2nd4 804 17 ( ( -LRB- cord-009571-mygj2nd4 804 18 49000 49000 CD cord-009571-mygj2nd4 804 19 X x NN cord-009571-mygj2nd4 804 20 g g NN cord-009571-mygj2nd4 804 21 ) ) -RRB- cord-009571-mygj2nd4 804 22 , , , cord-009571-mygj2nd4 804 23 and and CC cord-009571-mygj2nd4 804 24 expressed express VBD cord-009571-mygj2nd4 804 25 as as IN cord-009571-mygj2nd4 804 26 percent percent NN cord-009571-mygj2nd4 804 27 loss loss NN cord-009571-mygj2nd4 804 28 of of IN cord-009571-mygj2nd4 804 29 nuclide nuclide NN cord-009571-mygj2nd4 804 30 from from IN cord-009571-mygj2nd4 804 31 the the DT cord-009571-mygj2nd4 804 32 supernatant supernatant NN cord-009571-mygj2nd4 804 33 . . . cord-009571-mygj2nd4 805 1 Standard Standard NNP cord-009571-mygj2nd4 805 2 HA HA NNP cord-009571-mygj2nd4 805 3 binding bind VBG cord-009571-mygj2nd4 805 4 in in IN cord-009571-mygj2nd4 805 5 serum serum NN cord-009571-mygj2nd4 805 6 Monsodium Monsodium NNP cord-009571-mygj2nd4 805 7 urate urate NN cord-009571-mygj2nd4 805 8 or or CC cord-009571-mygj2nd4 805 9 calcium calcium NN cord-009571-mygj2nd4 805 10 pyrophosphate pyrophosphate NN cord-009571-mygj2nd4 805 11 dihydrate dihydrate NN cord-009571-mygj2nd4 805 12 ( ( -LRB- cord-009571-mygj2nd4 805 13 CPPD CPPD NNP cord-009571-mygj2nd4 805 14 ) ) -RRB- cord-009571-mygj2nd4 805 15 crystals crystal NNS cord-009571-mygj2nd4 805 16 failed fail VBD cord-009571-mygj2nd4 805 17 to to TO cord-009571-mygj2nd4 805 18 bind bind VB cord-009571-mygj2nd4 805 19 in in IN cord-009571-mygj2nd4 805 20 concentrations concentration NNS cord-009571-mygj2nd4 805 21 up up IN cord-009571-mygj2nd4 805 22 to to IN cord-009571-mygj2nd4 805 23 0.5 0.5 CD cord-009571-mygj2nd4 805 24 mg mg NNP cord-009571-mygj2nd4 805 25 / / SYM cord-009571-mygj2nd4 805 26 ml ml NN cord-009571-mygj2nd4 805 27 and and CC cord-009571-mygj2nd4 805 28 1 1 CD cord-009571-mygj2nd4 806 1 .O .O . cord-009571-mygj2nd4 807 1 mg mg NNP cord-009571-mygj2nd4 807 2 / / SYM cord-009571-mygj2nd4 807 3 ml ml NNP cord-009571-mygj2nd4 807 4 respectively respectively RB cord-009571-mygj2nd4 807 5 . . . cord-009571-mygj2nd4 808 1 The the DT cord-009571-mygj2nd4 808 2 centrifuged centrifuge VBN cord-009571-mygj2nd4 808 3 pellets pellet NNS cord-009571-mygj2nd4 808 4 were be VBD cord-009571-mygj2nd4 808 5 washed wash VBN cord-009571-mygj2nd4 808 6 in in IN cord-009571-mygj2nd4 808 7 distilled distil VBN cord-009571-mygj2nd4 808 8 water water NN cord-009571-mygj2nd4 808 9 and and CC cord-009571-mygj2nd4 808 10 dried dry VBN cord-009571-mygj2nd4 808 11 to to IN cord-009571-mygj2nd4 808 12 a a DT cord-009571-mygj2nd4 808 13 spot spot NN cord-009571-mygj2nd4 808 14 which which WDT cord-009571-mygj2nd4 808 15 showed show VBD cord-009571-mygj2nd4 808 16 HA HA NNP cord-009571-mygj2nd4 808 17 by by IN cord-009571-mygj2nd4 808 18 x x NN cord-009571-mygj2nd4 808 19 - - NN cord-009571-mygj2nd4 808 20 ray ray NN cord-009571-mygj2nd4 808 21 diffraction diffraction NN cord-009571-mygj2nd4 808 22 . . . cord-009571-mygj2nd4 809 1 This this DT cord-009571-mygj2nd4 809 2 method method NN cord-009571-mygj2nd4 809 3 was be VBD cord-009571-mygj2nd4 809 4 sensitive sensitive JJ cord-009571-mygj2nd4 809 5 to to IN cord-009571-mygj2nd4 809 6 25 25 CD cord-009571-mygj2nd4 809 7 - - SYM cord-009571-mygj2nd4 809 8 50 50 CD cord-009571-mygj2nd4 809 9 pg pg NN cord-009571-mygj2nd4 809 10 HA HA NNP cord-009571-mygj2nd4 809 11 standard standard NN cord-009571-mygj2nd4 809 12 . . . cord-009571-mygj2nd4 810 1 We -PRON- PRP cord-009571-mygj2nd4 810 2 confirm confirm VBP cord-009571-mygj2nd4 810 3 the the DT cord-009571-mygj2nd4 810 4 finding finding NN cord-009571-mygj2nd4 810 5 of of IN cord-009571-mygj2nd4 810 6 HA HA NNP cord-009571-mygj2nd4 810 7 crystals crystal NNS cord-009571-mygj2nd4 810 8 in in IN cord-009571-mygj2nd4 810 9 joint joint JJ cord-009571-mygj2nd4 810 10 fluids fluid NNS cord-009571-mygj2nd4 810 11 , , , cord-009571-mygj2nd4 810 12 handled handle VBN cord-009571-mygj2nd4 810 13 physiologically physiologically RB cord-009571-mygj2nd4 810 14 , , , cord-009571-mygj2nd4 810 15 in in IN cord-009571-mygj2nd4 810 16 amounts amount NNS cord-009571-mygj2nd4 810 17 equal equal JJ cord-009571-mygj2nd4 810 18 to to IN cord-009571-mygj2nd4 810 19 1 1 CD cord-009571-mygj2nd4 810 20 - - SYM cord-009571-mygj2nd4 810 21 15 15 CD cord-009571-mygj2nd4 810 22 pg pg NN cord-009571-mygj2nd4 810 23 HA HA NNP cord-009571-mygj2nd4 810 24 standard standard NN cord-009571-mygj2nd4 810 25 / / , cord-009571-mygj2nd4 810 26 ml ml NN cord-009571-mygj2nd4 810 27 . . . cord-009571-mygj2nd4 811 1 Such such JJ cord-009571-mygj2nd4 811 2 small small JJ cord-009571-mygj2nd4 811 3 amounts amount NNS cord-009571-mygj2nd4 811 4 and and CC cord-009571-mygj2nd4 811 5 the the DT cord-009571-mygj2nd4 811 6 low low JJ cord-009571-mygj2nd4 811 7 WBC WBC NNP cord-009571-mygj2nd4 811 8 in in IN cord-009571-mygj2nd4 811 9 these these DT cord-009571-mygj2nd4 811 10 fluids fluid NNS cord-009571-mygj2nd4 811 11 fail fail VBP cord-009571-mygj2nd4 811 12 to to TO cord-009571-mygj2nd4 811 13 support support VB cord-009571-mygj2nd4 811 14 a a DT cord-009571-mygj2nd4 811 15 phlogistic phlogistic JJ cord-009571-mygj2nd4 811 16 role role NN cord-009571-mygj2nd4 811 17 for for IN cord-009571-mygj2nd4 811 18 HA HA NNP cord-009571-mygj2nd4 811 19 crystals crystal NNS cord-009571-mygj2nd4 811 20 . . . cord-009571-mygj2nd4 811 21 _SP cord-009571-mygj2nd4 812 1 Patients patient NNS cord-009571-mygj2nd4 812 2 with with IN cord-009571-mygj2nd4 812 3 systemic systemic JJ cord-009571-mygj2nd4 812 4 lupus lupus NN cord-009571-mygj2nd4 812 5 erythematosus erythematosus NN cord-009571-mygj2nd4 812 6 ( ( -LRB- cord-009571-mygj2nd4 812 7 SLE SLE NNP cord-009571-mygj2nd4 812 8 ) ) -RRB- cord-009571-mygj2nd4 812 9 have have VBP cord-009571-mygj2nd4 812 10 circulating circulate VBG cord-009571-mygj2nd4 812 11 immune immune JJ cord-009571-mygj2nd4 812 12 complexes complex NNS cord-009571-mygj2nd4 812 13 ( ( -LRB- cord-009571-mygj2nd4 812 14 IC IC NNP cord-009571-mygj2nd4 812 15 ) ) -RRB- cord-009571-mygj2nd4 812 16 which which WDT cord-009571-mygj2nd4 812 17 are be VBP cord-009571-mygj2nd4 812 18 thought think VBN cord-009571-mygj2nd4 812 19 to to TO cord-009571-mygj2nd4 812 20 be be VB cord-009571-mygj2nd4 812 21 involved involve VBN cord-009571-mygj2nd4 812 22 in in IN cord-009571-mygj2nd4 812 23 disease disease NN cord-009571-mygj2nd4 812 24 pathogenesis pathogenesis NN cord-009571-mygj2nd4 812 25 . . . cord-009571-mygj2nd4 813 1 Using use VBG cord-009571-mygj2nd4 813 2 a a DT cord-009571-mygj2nd4 813 3 newly newly RB cord-009571-mygj2nd4 813 4 described describe VBN cord-009571-mygj2nd4 813 5 method method NN cord-009571-mygj2nd4 813 6 for for IN cord-009571-mygj2nd4 813 7 in in IN cord-009571-mygj2nd4 813 8 vivo vivo NN cord-009571-mygj2nd4 813 9 evaluation evaluation NN cord-009571-mygj2nd4 813 10 of of IN cord-009571-mygj2nd4 813 11 RES RES NNP cord-009571-mygj2nd4 813 12 IgG igg NN cord-009571-mygj2nd4 813 13 Fc Fc NNP cord-009571-mygj2nd4 813 14 membrane membrane NN cord-009571-mygj2nd4 813 15 receptor receptor NN cord-009571-mygj2nd4 813 16 function function NN cord-009571-mygj2nd4 813 17 , , , cord-009571-mygj2nd4 813 18 we -PRON- PRP cord-009571-mygj2nd4 813 19 previously previously RB cord-009571-mygj2nd4 813 20 demonstrated demonstrate VBD cord-009571-mygj2nd4 813 21 a a DT cord-009571-mygj2nd4 813 22 defect defect NN cord-009571-mygj2nd4 813 23 in in IN cord-009571-mygj2nd4 813 24 untreated untreated JJ cord-009571-mygj2nd4 813 25 patients patient NNS cord-009571-mygj2nd4 813 26 with with IN cord-009571-mygj2nd4 813 27 active active JJ cord-009571-mygj2nd4 813 28 SLE SLE NNP cord-009571-mygj2nd4 813 29 and and CC cord-009571-mygj2nd4 813 30 related relate VBD cord-009571-mygj2nd4 813 31 this this DT cord-009571-mygj2nd4 813 32 RES res NN cord-009571-mygj2nd4 813 33 defect defect NN cord-009571-mygj2nd4 813 34 to to IN cord-009571-mygj2nd4 813 35 the the DT cord-009571-mygj2nd4 813 36 presence presence NN cord-009571-mygj2nd4 813 37 of of IN cord-009571-mygj2nd4 813 38 circulating circulate VBG cord-009571-mygj2nd4 813 39 immune immune JJ cord-009571-mygj2nd4 813 40 complexes complex NNS cord-009571-mygj2nd4 813 41 . . . cord-009571-mygj2nd4 814 1 A a DT cord-009571-mygj2nd4 814 2 serial serial JJ cord-009571-mygj2nd4 814 3 study study NN cord-009571-mygj2nd4 814 4 of of IN cord-009571-mygj2nd4 814 5 the the DT cord-009571-mygj2nd4 814 6 correlation correlation NN cord-009571-mygj2nd4 814 7 of of IN cord-009571-mygj2nd4 814 8 defective defective JJ cord-009571-mygj2nd4 814 9 RES RES NNP cord-009571-mygj2nd4 814 10 Fc Fc NNP cord-009571-mygj2nd4 814 11 receptor receptor NN cord-009571-mygj2nd4 814 12 function function NN cord-009571-mygj2nd4 814 13 , , , cord-009571-mygj2nd4 814 14 immune immune JJ cord-009571-mygj2nd4 814 15 complexes complex NNS cord-009571-mygj2nd4 814 16 , , , cord-009571-mygj2nd4 814 17 and and CC cord-009571-mygj2nd4 814 18 disease disease NN cord-009571-mygj2nd4 814 19 activity activity NN cord-009571-mygj2nd4 814 20 was be VBD cord-009571-mygj2nd4 814 21 undertaken undertake VBN cord-009571-mygj2nd4 814 22 to to TO cord-009571-mygj2nd4 814 23 further further RB cord-009571-mygj2nd4 814 24 investigate investigate VB cord-009571-mygj2nd4 814 25 the the DT cord-009571-mygj2nd4 814 26 interaction interaction NN cord-009571-mygj2nd4 814 27 of of IN cord-009571-mygj2nd4 814 28 these these DT cord-009571-mygj2nd4 814 29 factors factor NNS cord-009571-mygj2nd4 814 30 . . . cord-009571-mygj2nd4 815 1 Isologous Isologous NNP cord-009571-mygj2nd4 815 2 Yr Yr NNP cord-009571-mygj2nd4 815 3 - - HYPH cord-009571-mygj2nd4 815 4 labeled label VBN cord-009571-mygj2nd4 815 5 erythrocytes erythrocyte NNS cord-009571-mygj2nd4 815 6 were be VBD cord-009571-mygj2nd4 815 7 sensitized sensitize VBN cord-009571-mygj2nd4 815 8 with with IN cord-009571-mygj2nd4 815 9 human human JJ cord-009571-mygj2nd4 815 10 anti anti JJ cord-009571-mygj2nd4 815 11 - - JJ cord-009571-mygj2nd4 815 12 Rh(D rh(d JJ cord-009571-mygj2nd4 815 13 ) ) -RRB- cord-009571-mygj2nd4 815 14 and and CC cord-009571-mygj2nd4 815 15 their -PRON- PRP$ cord-009571-mygj2nd4 815 16 intravenous intravenous JJ cord-009571-mygj2nd4 815 17 clearance clearance NN cord-009571-mygj2nd4 815 18 determined determine VBN cord-009571-mygj2nd4 815 19 . . . cord-009571-mygj2nd4 816 1 Clearance clearance NN cord-009571-mygj2nd4 816 2 rates rate NNS cord-009571-mygj2nd4 816 3 ( ( -LRB- cord-009571-mygj2nd4 816 4 T-1/2 t-1/2 NN cord-009571-mygj2nd4 816 5 ) ) -RRB- cord-009571-mygj2nd4 816 6 C c NN cord-009571-mygj2nd4 816 7 ' ' POS cord-009571-mygj2nd4 816 8 levels level NNS cord-009571-mygj2nd4 816 9 and and CC cord-009571-mygj2nd4 816 10 IC IC NNP cord-009571-mygj2nd4 816 11 levels level NNS cord-009571-mygj2nd4 816 12 by by IN cord-009571-mygj2nd4 816 13 1z51-Clq 1z51-clq CD cord-009571-mygj2nd4 816 14 precipitation precipitation NN cord-009571-mygj2nd4 816 15 were be VBD cord-009571-mygj2nd4 816 16 determined determine VBN cord-009571-mygj2nd4 816 17 prior prior RB cord-009571-mygj2nd4 816 18 to to IN cord-009571-mygj2nd4 816 19 therapy therapy NN cord-009571-mygj2nd4 816 20 in in IN cord-009571-mygj2nd4 816 21 17 17 CD cord-009571-mygj2nd4 816 22 SLE SLE NNP cord-009571-mygj2nd4 816 23 patients patient NNS cord-009571-mygj2nd4 816 24 , , , cord-009571-mygj2nd4 816 25 12 12 CD cord-009571-mygj2nd4 816 26 of of IN cord-009571-mygj2nd4 816 27 whom whom WP cord-009571-mygj2nd4 816 28 had have VBD cord-009571-mygj2nd4 816 29 active active JJ cord-009571-mygj2nd4 816 30 disease disease NN cord-009571-mygj2nd4 816 31 . . . cord-009571-mygj2nd4 817 1 Fifteen fifteen CD cord-009571-mygj2nd4 817 2 of of IN cord-009571-mygj2nd4 817 3 17 17 CD cord-009571-mygj2nd4 817 4 had have VBD cord-009571-mygj2nd4 817 5 markedly markedly RB cord-009571-mygj2nd4 817 6 prolonged prolong VBN cord-009571-mygj2nd4 817 7 clearance clearance NN cord-009571-mygj2nd4 817 8 rates rate NNS cord-009571-mygj2nd4 817 9 ( ( -LRB- cord-009571-mygj2nd4 817 10 range range NN cord-009571-mygj2nd4 817 11 = = SYM cord-009571-mygj2nd4 817 12 80 80 CD cord-009571-mygj2nd4 817 13 to to IN cord-009571-mygj2nd4 817 14 > > XX cord-009571-mygj2nd4 817 15 1 1 CD cord-009571-mygj2nd4 817 16 , , , cord-009571-mygj2nd4 817 17 OOO OOO NNP cord-009571-mygj2nd4 817 18 minutes minute NNS cord-009571-mygj2nd4 817 19 ; ; : cord-009571-mygj2nd4 818 1 average average JJ cord-009571-mygj2nd4 818 2 clearance clearance NN cord-009571-mygj2nd4 818 3 T-1/2 t-1/2 NN cord-009571-mygj2nd4 818 4 in in IN cord-009571-mygj2nd4 818 5 14 14 CD cord-009571-mygj2nd4 818 6 normal normal JJ cord-009571-mygj2nd4 818 7 volunteers volunteer NNS cord-009571-mygj2nd4 818 8 = = . cord-009571-mygj2nd4 819 1 40 40 CD cord-009571-mygj2nd4 819 2 minutes minute NNS cord-009571-mygj2nd4 819 3 , , , cord-009571-mygj2nd4 819 4 range range VBP cord-009571-mygj2nd4 819 5 35 35 CD cord-009571-mygj2nd4 819 6 to to TO cord-009571-mygj2nd4 819 7 50 50 CD cord-009571-mygj2nd4 819 8 minutes minute NNS cord-009571-mygj2nd4 819 9 ) ) -RRB- cord-009571-mygj2nd4 819 10 . . . cord-009571-mygj2nd4 820 1 The the DT cord-009571-mygj2nd4 820 2 correlations correlation NNS cord-009571-mygj2nd4 820 3 of of IN cord-009571-mygj2nd4 820 4 clinical clinical JJ cord-009571-mygj2nd4 820 5 activity activity NN cord-009571-mygj2nd4 820 6 with with IN cord-009571-mygj2nd4 820 7 1 1 CD cord-009571-mygj2nd4 820 8 ) ) -RRB- cord-009571-mygj2nd4 821 1 Clq clq NN cord-009571-mygj2nd4 821 2 binding binding NN cord-009571-mygj2nd4 821 3 and and CC cord-009571-mygj2nd4 821 4 2 2 CD cord-009571-mygj2nd4 821 5 ) ) -RRB- cord-009571-mygj2nd4 821 6 prolonged prolonged JJ cord-009571-mygj2nd4 821 7 clearance clearance NN cord-009571-mygj2nd4 821 8 were be VBD cord-009571-mygj2nd4 821 9 statistically statistically RB cord-009571-mygj2nd4 821 10 sig sig NN cord-009571-mygj2nd4 821 11 - - HYPH cord-009571-mygj2nd4 821 12 nificant nificant JJ cord-009571-mygj2nd4 821 13 ( ( -LRB- cord-009571-mygj2nd4 821 14 P p NN cord-009571-mygj2nd4 821 15 < < XX cord-009571-mygj2nd4 821 16 0.005 0.005 XX cord-009571-mygj2nd4 821 17 and and CC cord-009571-mygj2nd4 821 18 P p NN cord-009571-mygj2nd4 821 19 < < XX cord-009571-mygj2nd4 821 20 0.05 0.05 CD cord-009571-mygj2nd4 821 21 , , , cord-009571-mygj2nd4 821 22 respectively respectively RB cord-009571-mygj2nd4 821 23 ; ; : cord-009571-mygj2nd4 821 24 Spearman Spearman NNP cord-009571-mygj2nd4 821 25 Rank Rank NNP cord-009571-mygj2nd4 821 26 Coefficient Coefficient NNP cord-009571-mygj2nd4 821 27 ) ) -RRB- cord-009571-mygj2nd4 821 28 . . . cord-009571-mygj2nd4 822 1 In in IN cord-009571-mygj2nd4 822 2 addition addition NN cord-009571-mygj2nd4 822 3 , , , cord-009571-mygj2nd4 822 4 elevated elevated JJ cord-009571-mygj2nd4 822 5 Clq Clq NNP cord-009571-mygj2nd4 822 6 binding bind VBG cord-009571-mygj2nd4 822 7 and and CC cord-009571-mygj2nd4 822 8 depressed depressed JJ cord-009571-mygj2nd4 822 9 C4 c4 NN cord-009571-mygj2nd4 822 10 levels level NNS cord-009571-mygj2nd4 822 11 were be VBD cord-009571-mygj2nd4 822 12 significantly significantly RB cord-009571-mygj2nd4 822 13 correlated correlate VBN cord-009571-mygj2nd4 822 14 ( ( -LRB- cord-009571-mygj2nd4 822 15 P p NN cord-009571-mygj2nd4 822 16 < < XX cord-009571-mygj2nd4 822 17 0.05 0.05 CD cord-009571-mygj2nd4 822 18 ) ) -RRB- cord-009571-mygj2nd4 822 19 . . . cord-009571-mygj2nd4 823 1 At at IN cord-009571-mygj2nd4 823 2 the the DT cord-009571-mygj2nd4 823 3 end end NN cord-009571-mygj2nd4 823 4 of of IN cord-009571-mygj2nd4 823 5 from from IN cord-009571-mygj2nd4 823 6 1 1 CD cord-009571-mygj2nd4 823 7 to to IN cord-009571-mygj2nd4 823 8 19 19 CD cord-009571-mygj2nd4 823 9 months month NNS cord-009571-mygj2nd4 823 10 , , , cord-009571-mygj2nd4 823 11 10 10 CD cord-009571-mygj2nd4 823 12 patients patient NNS cord-009571-mygj2nd4 823 13 who who WP cord-009571-mygj2nd4 823 14 initially initially RB cord-009571-mygj2nd4 823 15 had have VBD cord-009571-mygj2nd4 823 16 prolonged prolong VBN cord-009571-mygj2nd4 823 17 clearance clearance NN cord-009571-mygj2nd4 823 18 were be VBD cord-009571-mygj2nd4 823 19 restudied restudie VBN cord-009571-mygj2nd4 823 20 . . . cord-009571-mygj2nd4 824 1 Patients patient NNS cord-009571-mygj2nd4 824 2 had have VBD cord-009571-mygj2nd4 824 3 been be VBN cord-009571-mygj2nd4 824 4 treated treat VBN cord-009571-mygj2nd4 824 5 with with IN cord-009571-mygj2nd4 824 6 either either CC cord-009571-mygj2nd4 824 7 corticosteroids corticosteroid NNS cord-009571-mygj2nd4 824 8 ( ( -LRB- cord-009571-mygj2nd4 824 9 7 7 CD cord-009571-mygj2nd4 824 10 of of IN cord-009571-mygj2nd4 824 11 10 10 CD cord-009571-mygj2nd4 824 12 ) ) -RRB- cord-009571-mygj2nd4 824 13 or or CC cord-009571-mygj2nd4 824 14 nonsteroidal nonsteroidal JJ cord-009571-mygj2nd4 824 15 , , , cord-009571-mygj2nd4 824 16 antiinflammatory antiinflammatory JJ cord-009571-mygj2nd4 824 17 drugs drug NNS cord-009571-mygj2nd4 824 18 ( ( -LRB- cord-009571-mygj2nd4 824 19 3 3 CD cord-009571-mygj2nd4 824 20 of of IN cord-009571-mygj2nd4 824 21 10 10 CD cord-009571-mygj2nd4 824 22 ) ) -RRB- cord-009571-mygj2nd4 824 23 . . . cord-009571-mygj2nd4 825 1 Clinically clinically RB cord-009571-mygj2nd4 825 2 , , , cord-009571-mygj2nd4 825 3 7 7 CD cord-009571-mygj2nd4 825 4 of of IN cord-009571-mygj2nd4 825 5 10 10 CD cord-009571-mygj2nd4 825 6 were be VBD cord-009571-mygj2nd4 825 7 improved improve VBN cord-009571-mygj2nd4 825 8 ; ; : cord-009571-mygj2nd4 825 9 the the DT cord-009571-mygj2nd4 825 10 remaining remain VBG cord-009571-mygj2nd4 825 11 3 3 CD cord-009571-mygj2nd4 825 12 continued continue VBD cord-009571-mygj2nd4 825 13 to to TO cord-009571-mygj2nd4 825 14 do do VB cord-009571-mygj2nd4 825 15 well well RB cord-009571-mygj2nd4 825 16 . . . cord-009571-mygj2nd4 826 1 Although although IN cord-009571-mygj2nd4 826 2 a a DT cord-009571-mygj2nd4 826 3 clearance clearance NN cord-009571-mygj2nd4 826 4 defect defect NN cord-009571-mygj2nd4 826 5 persisted persist VBD cord-009571-mygj2nd4 826 6 in in IN cord-009571-mygj2nd4 826 7 all all DT cord-009571-mygj2nd4 826 8 10 10 CD cord-009571-mygj2nd4 826 9 ( ( -LRB- cord-009571-mygj2nd4 826 10 T-1/2 t-1/2 RB cord-009571-mygj2nd4 826 11 from from IN cord-009571-mygj2nd4 826 12 88 88 CD cord-009571-mygj2nd4 826 13 to to IN cord-009571-mygj2nd4 826 14 600 600 CD cord-009571-mygj2nd4 826 15 minutes minute NNS cord-009571-mygj2nd4 826 16 ) ) -RRB- cord-009571-mygj2nd4 826 17 , , , cord-009571-mygj2nd4 826 18 in in IN cord-009571-mygj2nd4 826 19 7 7 CD cord-009571-mygj2nd4 826 20 of of IN cord-009571-mygj2nd4 826 21 10 10 CD cord-009571-mygj2nd4 826 22 T-1/2 T-1/2 NNS cord-009571-mygj2nd4 826 23 was be VBD cord-009571-mygj2nd4 826 24 markedly markedly RB cord-009571-mygj2nd4 826 25 improved improve VBN cord-009571-mygj2nd4 826 26 , , , cord-009571-mygj2nd4 826 27 suggesting suggest VBG cord-009571-mygj2nd4 826 28 improved improve VBN cord-009571-mygj2nd4 826 29 Fc Fc NNP cord-009571-mygj2nd4 826 30 receptor receptor NN cord-009571-mygj2nd4 826 31 function function NN cord-009571-mygj2nd4 826 32 . . . cord-009571-mygj2nd4 827 1 In in IN cord-009571-mygj2nd4 827 2 7 7 CD cord-009571-mygj2nd4 827 3 patients patient NNS cord-009571-mygj2nd4 827 4 , , , cord-009571-mygj2nd4 827 5 there there EX cord-009571-mygj2nd4 827 6 was be VBD cord-009571-mygj2nd4 827 7 an an DT cord-009571-mygj2nd4 827 8 apparent apparent JJ cord-009571-mygj2nd4 827 9 correlation correlation NN cord-009571-mygj2nd4 827 10 between between IN cord-009571-mygj2nd4 827 11 increased increased JJ cord-009571-mygj2nd4 827 12 clearance clearance NN cord-009571-mygj2nd4 827 13 and and CC cord-009571-mygj2nd4 827 14 clinical clinical JJ cord-009571-mygj2nd4 827 15 improvement improvement NN cord-009571-mygj2nd4 827 16 . . . cord-009571-mygj2nd4 828 1 There there EX cord-009571-mygj2nd4 828 2 was be VBD cord-009571-mygj2nd4 828 3 also also RB cord-009571-mygj2nd4 828 4 a a DT cord-009571-mygj2nd4 828 5 significant significant JJ cord-009571-mygj2nd4 828 6 correlation correlation NN cord-009571-mygj2nd4 828 7 between between IN cord-009571-mygj2nd4 828 8 clinical clinical JJ cord-009571-mygj2nd4 828 9 improvement improvement NN cord-009571-mygj2nd4 828 10 and and CC cord-009571-mygj2nd4 828 11 a a DT cord-009571-mygj2nd4 828 12 decrease decrease NN cord-009571-mygj2nd4 828 13 in in IN cord-009571-mygj2nd4 828 14 Clq Clq NNP cord-009571-mygj2nd4 828 15 binding binding NN cord-009571-mygj2nd4 828 16 ( ( -LRB- cord-009571-mygj2nd4 828 17 P p NN cord-009571-mygj2nd4 828 18 < < XX cord-009571-mygj2nd4 828 19 0.05 0.05 CD cord-009571-mygj2nd4 828 20 ) ) -RRB- cord-009571-mygj2nd4 828 21 . . . cord-009571-mygj2nd4 829 1 These these DT cord-009571-mygj2nd4 829 2 studies study NNS cord-009571-mygj2nd4 829 3 underscore underscore VBP cord-009571-mygj2nd4 829 4 the the DT cord-009571-mygj2nd4 829 5 interrelationships interrelationship NNS cord-009571-mygj2nd4 829 6 between between IN cord-009571-mygj2nd4 829 7 the the DT cord-009571-mygj2nd4 829 8 presence presence NN cord-009571-mygj2nd4 829 9 of of IN cord-009571-mygj2nd4 829 10 circulating circulate VBG cord-009571-mygj2nd4 829 11 immune immune JJ cord-009571-mygj2nd4 829 12 complexes complex NNS cord-009571-mygj2nd4 829 13 , , , cord-009571-mygj2nd4 829 14 defects defect NNS cord-009571-mygj2nd4 829 15 in in IN cord-009571-mygj2nd4 829 16 membrane membrane NN cord-009571-mygj2nd4 829 17 Fc Fc NNP cord-009571-mygj2nd4 829 18 receptor receptor NN cord-009571-mygj2nd4 829 19 function function NN cord-009571-mygj2nd4 829 20 which which WDT cord-009571-mygj2nd4 829 21 might may MD cord-009571-mygj2nd4 829 22 lead lead VB cord-009571-mygj2nd4 829 23 to to IN cord-009571-mygj2nd4 829 24 continued continue VBN cord-009571-mygj2nd4 829 25 circulation circulation NN cord-009571-mygj2nd4 829 26 of of IN cord-009571-mygj2nd4 829 27 these these DT cord-009571-mygj2nd4 829 28 complexes complex NNS cord-009571-mygj2nd4 829 29 , , , cord-009571-mygj2nd4 829 30 and and CC cord-009571-mygj2nd4 829 31 disease disease NN cord-009571-mygj2nd4 829 32 activity activity NN cord-009571-mygj2nd4 829 33 in in IN cord-009571-mygj2nd4 829 34 SLE SLE NNP cord-009571-mygj2nd4 829 35 . . . cord-009571-mygj2nd4 830 1 We -PRON- PRP cord-009571-mygj2nd4 830 2 have have VBP cord-009571-mygj2nd4 830 3 found find VBN cord-009571-mygj2nd4 830 4 immune immune JJ cord-009571-mygj2nd4 830 5 complexes complex NNS cord-009571-mygj2nd4 830 6 in in IN cord-009571-mygj2nd4 830 7 patients patient NNS cord-009571-mygj2nd4 830 8 with with IN cord-009571-mygj2nd4 830 9 Lyme Lyme NNP cord-009571-mygj2nd4 830 10 arthritis arthritis NN cord-009571-mygj2nd4 830 11 , , , cord-009571-mygj2nd4 830 12 an an DT cord-009571-mygj2nd4 830 13 apparently apparently RB cord-009571-mygj2nd4 830 14 tick tick NN cord-009571-mygj2nd4 830 15 - - HYPH cord-009571-mygj2nd4 830 16 transmitted transmit VBN cord-009571-mygj2nd4 830 17 illness illness NN cord-009571-mygj2nd4 830 18 that that WDT cord-009571-mygj2nd4 830 19 typically typically RB cord-009571-mygj2nd4 830 20 begins begin VBZ cord-009571-mygj2nd4 830 21 with with IN cord-009571-mygj2nd4 830 22 the the DT cord-009571-mygj2nd4 830 23 skin skin NN cord-009571-mygj2nd4 830 24 lesion lesion NN cord-009571-mygj2nd4 830 25 , , , cord-009571-mygj2nd4 830 26 erythema erythema NN cord-009571-mygj2nd4 830 27 chronicum chronicum NN cord-009571-mygj2nd4 830 28 migrans migran NNS cord-009571-mygj2nd4 830 29 ( ( -LRB- cord-009571-mygj2nd4 830 30 ECM ECM NNP cord-009571-mygj2nd4 830 31 ) ) -RRB- cord-009571-mygj2nd4 830 32 . . . cord-009571-mygj2nd4 831 1 Many many JJ cord-009571-mygj2nd4 831 2 patients patient NNS cord-009571-mygj2nd4 831 3 subsequently subsequently RB cord-009571-mygj2nd4 831 4 develop develop VBP cord-009571-mygj2nd4 831 5 clinical clinical JJ cord-009571-mygj2nd4 831 6 attacks attack NNS cord-009571-mygj2nd4 831 7 of of IN cord-009571-mygj2nd4 831 8 synovitis synovitis NNP cord-009571-mygj2nd4 831 9 histologically histologically RB cord-009571-mygj2nd4 831 10 like like IN cord-009571-mygj2nd4 831 11 that that DT cord-009571-mygj2nd4 831 12 of of IN cord-009571-mygj2nd4 831 13 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 831 14 arthritis arthritis NN cord-009571-mygj2nd4 831 15 ; ; : cord-009571-mygj2nd4 831 16 some some DT cord-009571-mygj2nd4 831 17 also also RB cord-009571-mygj2nd4 831 18 develop develop VBP cord-009571-mygj2nd4 831 19 other other JJ cord-009571-mygj2nd4 831 20 systemic systemic JJ cord-009571-mygj2nd4 831 21 complications complication NNS cord-009571-mygj2nd4 831 22 ( ( -LRB- cord-009571-mygj2nd4 831 23 aseptic aseptic JJ cord-009571-mygj2nd4 831 24 meningitis meningitis NN cord-009571-mygj2nd4 831 25 , , , cord-009571-mygj2nd4 831 26 peripheral peripheral JJ cord-009571-mygj2nd4 831 27 neuropathy neuropathy NN cord-009571-mygj2nd4 831 28 , , , cord-009571-mygj2nd4 831 29 or or CC cord-009571-mygj2nd4 831 30 carditis carditis NNP cord-009571-mygj2nd4 831 31 ) ) -RRB- cord-009571-mygj2nd4 831 32 . . . cord-009571-mygj2nd4 832 1 We -PRON- PRP cord-009571-mygj2nd4 832 2 measured measure VBD cord-009571-mygj2nd4 832 3 circulating circulate VBG cord-009571-mygj2nd4 832 4 immune immune JJ cord-009571-mygj2nd4 832 5 complexes complex NNS cord-009571-mygj2nd4 832 6 ( ( -LRB- cord-009571-mygj2nd4 832 7 CIC CIC NNP cord-009571-mygj2nd4 832 8 ) ) -RRB- cord-009571-mygj2nd4 832 9 serially serially RB cord-009571-mygj2nd4 832 10 in in IN cord-009571-mygj2nd4 832 11 58 58 CD cord-009571-mygj2nd4 832 12 patients patient NNS cord-009571-mygj2nd4 832 13 with with IN cord-009571-mygj2nd4 832 14 ECM ECM NNP cord-009571-mygj2nd4 832 15 , , , cord-009571-mygj2nd4 832 16 by by IN cord-009571-mygj2nd4 832 17 the the DT cord-009571-mygj2nd4 832 18 l*sI l*si NN cord-009571-mygj2nd4 832 19 - - HYPH cord-009571-mygj2nd4 832 20 Clq Clq NNP cord-009571-mygj2nd4 832 21 binding binding NN cord-009571-mygj2nd4 832 22 assay assay NN cord-009571-mygj2nd4 832 23 . . . cord-009571-mygj2nd4 833 1 The the DT cord-009571-mygj2nd4 833 2 table table NN cord-009571-mygj2nd4 833 3 shows show VBZ cord-009571-mygj2nd4 833 4 the the DT cord-009571-mygj2nd4 833 5 first first JJ cord-009571-mygj2nd4 833 6 test test NN cord-009571-mygj2nd4 833 7 result result NN cord-009571-mygj2nd4 833 8 on on IN cord-009571-mygj2nd4 833 9 each each DT cord-009571-mygj2nd4 833 10 patient patient NN cord-009571-mygj2nd4 833 11 's 's POS cord-009571-mygj2nd4 833 12 serum serum NN cord-009571-mygj2nd4 833 13 in in IN cord-009571-mygj2nd4 833 14 each each DT cord-009571-mygj2nd4 833 15 of of IN cord-009571-mygj2nd4 833 16 the the DT cord-009571-mygj2nd4 833 17 designated designate VBN cord-009571-mygj2nd4 833 18 categories category NNS cord-009571-mygj2nd4 833 19 . . . cord-009571-mygj2nd4 834 1 Circulating circulate VBG cord-009571-mygj2nd4 834 2 immune immune JJ cord-009571-mygj2nd4 834 3 complexes complex NNS cord-009571-mygj2nd4 834 4 - - : cord-009571-mygj2nd4 834 5 an an DT cord-009571-mygj2nd4 834 6 antigenic antigenic JJ cord-009571-mygj2nd4 834 7 component component NN cord-009571-mygj2nd4 834 8 of of IN cord-009571-mygj2nd4 834 9 which which WDT cord-009571-mygj2nd4 834 10 may may MD cord-009571-mygj2nd4 834 11 be be VB cord-009571-mygj2nd4 834 12 related relate VBN cord-009571-mygj2nd4 834 13 to to IN cord-009571-mygj2nd4 834 14 the the DT cord-009571-mygj2nd4 834 15 causative causative JJ cord-009571-mygj2nd4 834 16 agent agent NN cord-009571-mygj2nd4 834 17 - - : cord-009571-mygj2nd4 834 18 were be VBD cord-009571-mygj2nd4 834 19 almost almost RB cord-009571-mygj2nd4 834 20 always always RB cord-009571-mygj2nd4 834 21 present present JJ cord-009571-mygj2nd4 834 22 very very RB cord-009571-mygj2nd4 834 23 early early RB cord-009571-mygj2nd4 834 24 in in IN cord-009571-mygj2nd4 834 25 the the DT cord-009571-mygj2nd4 834 26 illness illness NN cord-009571-mygj2nd4 834 27 and and CC cord-009571-mygj2nd4 834 28 in in IN cord-009571-mygj2nd4 834 29 patients patient NNS cord-009571-mygj2nd4 834 30 with with IN cord-009571-mygj2nd4 834 31 systemic systemic JJ cord-009571-mygj2nd4 834 32 complications complication NNS cord-009571-mygj2nd4 834 33 . . . cord-009571-mygj2nd4 835 1 In in IN cord-009571-mygj2nd4 835 2 contrast contrast NN cord-009571-mygj2nd4 835 3 , , , cord-009571-mygj2nd4 835 4 they -PRON- PRP cord-009571-mygj2nd4 835 5 were be VBD cord-009571-mygj2nd4 835 6 found find VBN cord-009571-mygj2nd4 835 7 less less RBR cord-009571-mygj2nd4 835 8 often often RB cord-009571-mygj2nd4 835 9 during during IN cord-009571-mygj2nd4 835 10 attacks attack NNS cord-009571-mygj2nd4 835 11 of of IN cord-009571-mygj2nd4 835 12 arthritis arthritis NN cord-009571-mygj2nd4 835 13 and and CC cord-009571-mygj2nd4 835 14 still still RB cord-009571-mygj2nd4 835 15 less less RBR cord-009571-mygj2nd4 835 16 often often RB cord-009571-mygj2nd4 835 17 during during IN cord-009571-mygj2nd4 835 18 remissions remission NNS cord-009571-mygj2nd4 835 19 . . . cord-009571-mygj2nd4 836 1 Quantitative quantitative JJ cord-009571-mygj2nd4 836 2 levels level NNS cord-009571-mygj2nd4 836 3 tended tend VBD cord-009571-mygj2nd4 836 4 to to TO cord-009571-mygj2nd4 836 5 diminish diminish VB cord-009571-mygj2nd4 836 6 with with IN cord-009571-mygj2nd4 836 7 time time NN cord-009571-mygj2nd4 836 8 ; ; : cord-009571-mygj2nd4 836 9 in in IN cord-009571-mygj2nd4 836 10 individual individual JJ cord-009571-mygj2nd4 836 11 patients patient NNS cord-009571-mygj2nd4 836 12 they -PRON- PRP cord-009571-mygj2nd4 836 13 fluctuated fluctuate VBD cord-009571-mygj2nd4 836 14 in in IN cord-009571-mygj2nd4 836 15 a a DT cord-009571-mygj2nd4 836 16 dampened dampen VBN cord-009571-mygj2nd4 836 17 hemi hemi NN cord-009571-mygj2nd4 836 18 - - HYPH cord-009571-mygj2nd4 836 19 sinewave sinewave JJ cord-009571-mygj2nd4 836 20 pattern pattern NN cord-009571-mygj2nd4 836 21 in in IN cord-009571-mygj2nd4 836 22 parallel parallel NN cord-009571-mygj2nd4 836 23 with with IN cord-009571-mygj2nd4 836 24 recurrent recurrent JJ cord-009571-mygj2nd4 836 25 bouts bout NNS cord-009571-mygj2nd4 836 26 of of IN cord-009571-mygj2nd4 836 27 active active JJ cord-009571-mygj2nd4 836 28 disease disease NN cord-009571-mygj2nd4 836 29 . . . cord-009571-mygj2nd4 837 1 Synovial synovial JJ cord-009571-mygj2nd4 837 2 fluid fluid NN cord-009571-mygj2nd4 837 3 from from IN cord-009571-mygj2nd4 837 4 all all DT cord-009571-mygj2nd4 837 5 of of IN cord-009571-mygj2nd4 837 6 7 7 CD cord-009571-mygj2nd4 837 7 patients patient NNS cord-009571-mygj2nd4 837 8 contained contain VBD cord-009571-mygj2nd4 837 9 immune immune JJ cord-009571-mygj2nd4 837 10 complexes complex NNS cord-009571-mygj2nd4 837 11 , , , cord-009571-mygj2nd4 837 12 compared compare VBN cord-009571-mygj2nd4 837 13 to to IN cord-009571-mygj2nd4 837 14 only only RB cord-009571-mygj2nd4 837 15 3 3 CD cord-009571-mygj2nd4 837 16 of of IN cord-009571-mygj2nd4 837 17 7 7 CD cord-009571-mygj2nd4 837 18 concomitant concomitant JJ cord-009571-mygj2nd4 837 19 sera sera NNP cord-009571-mygj2nd4 837 20 . . . cord-009571-mygj2nd4 838 1 In in IN cord-009571-mygj2nd4 838 2 the the DT cord-009571-mygj2nd4 838 3 3 3 CD cord-009571-mygj2nd4 838 4 positive positive JJ cord-009571-mygj2nd4 838 5 sera sera NNP cord-009571-mygj2nd4 838 6 the the DT cord-009571-mygj2nd4 838 7 concentrations concentration NNS cord-009571-mygj2nd4 838 8 were be VBD cord-009571-mygj2nd4 838 9 much much RB cord-009571-mygj2nd4 838 10 less less JJR cord-009571-mygj2nd4 838 11 than than IN cord-009571-mygj2nd4 838 12 in in IN cord-009571-mygj2nd4 838 13 the the DT cord-009571-mygj2nd4 838 14 corresponding correspond VBG cord-009571-mygj2nd4 838 15 joint joint JJ cord-009571-mygj2nd4 838 16 fluids fluid NNS cord-009571-mygj2nd4 838 17 . . . cord-009571-mygj2nd4 839 1 We -PRON- PRP cord-009571-mygj2nd4 839 2 suggest suggest VBP cord-009571-mygj2nd4 839 3 that that IN cord-009571-mygj2nd4 839 4 the the DT cord-009571-mygj2nd4 839 5 causative causative JJ cord-009571-mygj2nd4 839 6 agent agent NN cord-009571-mygj2nd4 839 7 is be VBZ cord-009571-mygj2nd4 839 8 introduced introduce VBN cord-009571-mygj2nd4 839 9 into into IN cord-009571-mygj2nd4 839 10 the the DT cord-009571-mygj2nd4 839 11 skin skin NN cord-009571-mygj2nd4 839 12 , , , cord-009571-mygj2nd4 839 13 where where WRB cord-009571-mygj2nd4 839 14 ECM ECM NNP cord-009571-mygj2nd4 839 15 is be VBZ cord-009571-mygj2nd4 839 16 the the DT cord-009571-mygj2nd4 839 17 initial initial JJ cord-009571-mygj2nd4 839 18 clinical clinical JJ cord-009571-mygj2nd4 839 19 manifestation manifestation NN cord-009571-mygj2nd4 839 20 of of IN cord-009571-mygj2nd4 839 21 a a DT cord-009571-mygj2nd4 839 22 systemic systemic JJ cord-009571-mygj2nd4 839 23 , , , cord-009571-mygj2nd4 839 24 immune immune JJ cord-009571-mygj2nd4 839 25 - - HYPH cord-009571-mygj2nd4 839 26 mediated mediate VBN cord-009571-mygj2nd4 839 27 inflammatory inflammatory JJ cord-009571-mygj2nd4 839 28 disorder disorder NN cord-009571-mygj2nd4 839 29 that that WDT cord-009571-mygj2nd4 839 30 often often RB cord-009571-mygj2nd4 839 31 becomes become VBZ cord-009571-mygj2nd4 839 32 localized localize VBN cord-009571-mygj2nd4 839 33 to to IN cord-009571-mygj2nd4 839 34 and and CC cord-009571-mygj2nd4 839 35 propagated propagate VBN cord-009571-mygj2nd4 839 36 in in IN cord-009571-mygj2nd4 839 37 synovium synovium NNP cord-009571-mygj2nd4 839 38 . . . cord-009571-mygj2nd4 840 1 Thus thus RB cord-009571-mygj2nd4 840 2 , , , cord-009571-mygj2nd4 840 3 Lyme Lyme NNP cord-009571-mygj2nd4 840 4 arthritis arthritis NN cord-009571-mygj2nd4 840 5 can can MD cord-009571-mygj2nd4 840 6 be be VB cord-009571-mygj2nd4 840 7 considered consider VBN cord-009571-mygj2nd4 840 8 a a DT cord-009571-mygj2nd4 840 9 human human JJ cord-009571-mygj2nd4 840 10 model model NN cord-009571-mygj2nd4 840 11 for for IN cord-009571-mygj2nd4 840 12 an an DT cord-009571-mygj2nd4 840 13 infectious infectious JJ cord-009571-mygj2nd4 840 14 etiology etiology NN cord-009571-mygj2nd4 840 15 of of IN cord-009571-mygj2nd4 840 16 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 840 17 arthritis arthritis NN cord-009571-mygj2nd4 840 18 . . . cord-009571-mygj2nd4 840 19 _SP cord-009571-mygj2nd4 841 1 Little little JJ cord-009571-mygj2nd4 841 2 attention attention NN cord-009571-mygj2nd4 841 3 has have VBZ cord-009571-mygj2nd4 841 4 been be VBN cord-009571-mygj2nd4 841 5 given give VBN cord-009571-mygj2nd4 841 6 to to IN cord-009571-mygj2nd4 841 7 analgesia analgesia NN cord-009571-mygj2nd4 841 8 , , , cord-009571-mygj2nd4 841 9 divorced divorce VBN cord-009571-mygj2nd4 841 10 from from IN cord-009571-mygj2nd4 841 11 suppression suppression NN cord-009571-mygj2nd4 841 12 of of IN cord-009571-mygj2nd4 841 13 inflammation inflammation NN cord-009571-mygj2nd4 841 14 , , , cord-009571-mygj2nd4 841 15 in in IN cord-009571-mygj2nd4 841 16 rheumatoid rheumatoid NN cord-009571-mygj2nd4 841 17 arthritis arthritis NN cord-009571-mygj2nd4 841 18 ( ( -LRB- cord-009571-mygj2nd4 841 19 RA RA NNP cord-009571-mygj2nd4 841 20 ) ) -RRB- cord-009571-mygj2nd4 841 21 , , , cord-009571-mygj2nd4 841 22 despite despite IN cord-009571-mygj2nd4 841 23 its -PRON- PRP$ cord-009571-mygj2nd4 841 24 importance importance NN cord-009571-mygj2nd4 841 25 to to IN cord-009571-mygj2nd4 841 26 patients patient NNS cord-009571-mygj2nd4 841 27 . . . cord-009571-mygj2nd4 842 1 This this DT cord-009571-mygj2nd4 842 2 study study NN cord-009571-mygj2nd4 842 3 was be VBD cord-009571-mygj2nd4 842 4 designed design VBN cord-009571-mygj2nd4 842 5 to to TO cord-009571-mygj2nd4 842 6 determine determine VB cord-009571-mygj2nd4 842 7 the the DT cord-009571-mygj2nd4 842 8 comparative comparative JJ cord-009571-mygj2nd4 842 9 efficacy efficacy NN cord-009571-mygj2nd4 842 10 of of IN cord-009571-mygj2nd4 842 11 five five CD cord-009571-mygj2nd4 842 12 often often RB cord-009571-mygj2nd4 842 13 used use VBN cord-009571-mygj2nd4 842 14 analgetics analgetic NNS cord-009571-mygj2nd4 842 15 for for IN cord-009571-mygj2nd4 842 16 the the DT cord-009571-mygj2nd4 842 17 pain pain NN cord-009571-mygj2nd4 842 18 of of IN cord-009571-mygj2nd4 842 19 active active JJ cord-009571-mygj2nd4 842 20 RA RA NNP cord-009571-mygj2nd4 842 21 synovitis synovitis NN cord-009571-mygj2nd4 842 22 . . . cord-009571-mygj2nd4 843 1 Single single JJ cord-009571-mygj2nd4 843 2 doses dose NNS cord-009571-mygj2nd4 843 3 of of IN cord-009571-mygj2nd4 843 4 650 650 CD cord-009571-mygj2nd4 843 5 mg mg NN cord-009571-mygj2nd4 843 6 aspirin aspirin NN cord-009571-mygj2nd4 843 7 ( ( -LRB- cord-009571-mygj2nd4 843 8 ASA ASA NNP cord-009571-mygj2nd4 843 9 ) ) -RRB- cord-009571-mygj2nd4 843 10 , , , cord-009571-mygj2nd4 843 11 650 650 CD cord-009571-mygj2nd4 843 12 mg mg NN cord-009571-mygj2nd4 843 13 acetaminophen acetaminophen NN cord-009571-mygj2nd4 843 14 ( ( -LRB- cord-009571-mygj2nd4 843 15 Ac Ac NNP cord-009571-mygj2nd4 843 16 ) ) -RRB- cord-009571-mygj2nd4 843 17 , , , cord-009571-mygj2nd4 843 18 65 65 CD cord-009571-mygj2nd4 843 19 mg mg NN cord-009571-mygj2nd4 843 20 codeine codeine NN cord-009571-mygj2nd4 843 21 ( ( -LRB- cord-009571-mygj2nd4 843 22 Co Co NNP cord-009571-mygj2nd4 843 23 ) ) -RRB- cord-009571-mygj2nd4 843 24 , , , cord-009571-mygj2nd4 843 25 50 50 CD cord-009571-mygj2nd4 843 26 mg mg NNP cord-009571-mygj2nd4 843 27 pentazocine pentazocine NNP cord-009571-mygj2nd4 843 28 ( ( -LRB- cord-009571-mygj2nd4 843 29 Pe Pe NNP cord-009571-mygj2nd4 843 30 ) ) -RRB- cord-009571-mygj2nd4 843 31 , , . cord-009571-mygj2nd4 844 1 65 65 CD cord-009571-mygj2nd4 844 2 mg mg NN cord-009571-mygj2nd4 844 3 propoxyphene propoxyphene JJ cord-009571-mygj2nd4 844 4 ( ( -LRB- cord-009571-mygj2nd4 844 5 Pro Pro NNP cord-009571-mygj2nd4 844 6 ) ) -RRB- cord-009571-mygj2nd4 844 7 , , , cord-009571-mygj2nd4 844 8 and and CC cord-009571-mygj2nd4 844 9 placebo placebo NN cord-009571-mygj2nd4 844 10 ( ( -LRB- cord-009571-mygj2nd4 844 11 PI PI NNP cord-009571-mygj2nd4 844 12 ) ) -RRB- cord-009571-mygj2nd4 844 13 were be VBD cord-009571-mygj2nd4 844 14 given give VBN cord-009571-mygj2nd4 844 15 in in IN cord-009571-mygj2nd4 844 16 a a DT cord-009571-mygj2nd4 844 17 randomized randomized JJ cord-009571-mygj2nd4 844 18 double double JJ cord-009571-mygj2nd4 844 19 blind blind JJ cord-009571-mygj2nd4 844 20 fashion fashion NN cord-009571-mygj2nd4 844 21 , , , cord-009571-mygj2nd4 844 22 and and CC cord-009571-mygj2nd4 844 23 on on IN cord-009571-mygj2nd4 844 24 a a DT cord-009571-mygj2nd4 844 25 PRN PRN NNP cord-009571-mygj2nd4 844 26 basis basis NN cord-009571-mygj2nd4 844 27 , , , cord-009571-mygj2nd4 844 28 to to IN cord-009571-mygj2nd4 844 29 each each DT cord-009571-mygj2nd4 844 30 of of IN cord-009571-mygj2nd4 844 31 30 30 CD cord-009571-mygj2nd4 844 32 carefully carefully RB cord-009571-mygj2nd4 844 33 selected select VBN cord-009571-mygj2nd4 844 34 hospitalized hospitalize VBN cord-009571-mygj2nd4 844 35 R r NN cord-009571-mygj2nd4 844 36 A a DT cord-009571-mygj2nd4 844 37 patients patient NNS cord-009571-mygj2nd4 844 38 with with IN cord-009571-mygj2nd4 844 39 painful painful JJ cord-009571-mygj2nd4 844 40 synovitis synovitis NN cord-009571-mygj2nd4 844 41 of of IN cord-009571-mygj2nd4 844 42 at at RB cord-009571-mygj2nd4 844 43 least least JJS cord-009571-mygj2nd4 844 44 4 4 CD cord-009571-mygj2nd4 844 45 joints joint NNS cord-009571-mygj2nd4 844 46 . . . cord-009571-mygj2nd4 845 1 All all DT cord-009571-mygj2nd4 845 2 other other JJ cord-009571-mygj2nd4 845 3 drugs drug NNS cord-009571-mygj2nd4 845 4 and and CC cord-009571-mygj2nd4 845 5 distracting distract VBG cord-009571-mygj2nd4 845 6 activities activity NNS cord-009571-mygj2nd4 845 7 were be VBD cord-009571-mygj2nd4 845 8 prohibited prohibit VBN cord-009571-mygj2nd4 845 9 during during IN cord-009571-mygj2nd4 845 10 the the DT cord-009571-mygj2nd4 845 11 study study NN cord-009571-mygj2nd4 845 12 period period NN cord-009571-mygj2nd4 845 13 and and CC cord-009571-mygj2nd4 845 14 at at RB cord-009571-mygj2nd4 845 15 least least JJS cord-009571-mygj2nd4 845 16 6 6 CD cord-009571-mygj2nd4 845 17 hours hour NNS cord-009571-mygj2nd4 845 18 of of IN cord-009571-mygj2nd4 845 19 observation observation NN cord-009571-mygj2nd4 845 20 required require VBN cord-009571-mygj2nd4 845 21 between between IN cord-009571-mygj2nd4 845 22 doses dose NNS cord-009571-mygj2nd4 845 23 of of IN cord-009571-mygj2nd4 845 24 test test NN cord-009571-mygj2nd4 845 25 agents agent NNS cord-009571-mygj2nd4 845 26 . . . cord-009571-mygj2nd4 846 1 Subjects subject NNS cord-009571-mygj2nd4 846 2 recorded record VBD cord-009571-mygj2nd4 846 3 time time NN cord-009571-mygj2nd4 846 4 of of IN cord-009571-mygj2nd4 846 5 onset onset NN cord-009571-mygj2nd4 846 6 and and CC cord-009571-mygj2nd4 846 7 duration duration NN cord-009571-mygj2nd4 846 8 of of IN cord-009571-mygj2nd4 846 9 maximal maximal JJ cord-009571-mygj2nd4 846 10 relief relief NN cord-009571-mygj2nd4 846 11 , , , cord-009571-mygj2nd4 846 12 percent percent NN cord-009571-mygj2nd4 846 13 of of IN cord-009571-mygj2nd4 846 14 relief relief NN cord-009571-mygj2nd4 846 15 achieved achieve VBN cord-009571-mygj2nd4 846 16 from from IN cord-009571-mygj2nd4 846 17 each each DT cord-009571-mygj2nd4 846 18 agent agent NN cord-009571-mygj2nd4 846 19 and and CC cord-009571-mygj2nd4 846 20 all all DT cord-009571-mygj2nd4 846 21 possible possible JJ cord-009571-mygj2nd4 846 22 side side NN cord-009571-mygj2nd4 846 23 effects effect NNS cord-009571-mygj2nd4 846 24 , , , cord-009571-mygj2nd4 846 25 and and CC cord-009571-mygj2nd4 846 26 , , , cord-009571-mygj2nd4 846 27 after after IN cord-009571-mygj2nd4 846 28 taking take VBG cord-009571-mygj2nd4 846 29 all all DT cord-009571-mygj2nd4 846 30 6 6 CD cord-009571-mygj2nd4 846 31 agents agent NNS cord-009571-mygj2nd4 846 32 , , , cord-009571-mygj2nd4 846 33 ranked rank VBD cord-009571-mygj2nd4 846 34 their -PRON- PRP$ cord-009571-mygj2nd4 846 35 order order NN cord-009571-mygj2nd4 846 36 of of IN cord-009571-mygj2nd4 846 37 preference preference NN cord-009571-mygj2nd4 846 38 , , , cord-009571-mygj2nd4 846 39 with with IN cord-009571-mygj2nd4 846 40 1 1 CD cord-009571-mygj2nd4 846 41 as as RB cord-009571-mygj2nd4 846 42 most most JJS cord-009571-mygj2nd4 846 43 effective effective JJ cord-009571-mygj2nd4 846 44 . . . cord-009571-mygj2nd4 847 1 Onset onset NN cord-009571-mygj2nd4 847 2 and and CC cord-009571-mygj2nd4 847 3 duration duration NN cord-009571-mygj2nd4 847 4 of of IN cord-009571-mygj2nd4 847 5 action action NN cord-009571-mygj2nd4 847 6 of of IN cord-009571-mygj2nd4 847 7 all all DT cord-009571-mygj2nd4 847 8 agents agent NNS cord-009571-mygj2nd4 847 9 were be VBD cord-009571-mygj2nd4 847 10 similar similar JJ cord-009571-mygj2nd4 847 11 except except IN cord-009571-mygj2nd4 847 12 Ac Ac NNP cord-009571-mygj2nd4 847 13 and and CC cord-009571-mygj2nd4 847 14 PI PI NNP cord-009571-mygj2nd4 847 15 , , , cord-009571-mygj2nd4 847 16 which which WDT cord-009571-mygj2nd4 847 17 required require VBD cord-009571-mygj2nd4 847 18 longer long RBR cord-009571-mygj2nd4 847 19 to to TO cord-009571-mygj2nd4 847 20 act act VB cord-009571-mygj2nd4 847 21 and and CC cord-009571-mygj2nd4 847 22 lasted last VBD cord-009571-mygj2nd4 847 23 a a DT cord-009571-mygj2nd4 847 24 shorter short JJR cord-009571-mygj2nd4 847 25 time time NN cord-009571-mygj2nd4 847 26 . . . cord-009571-mygj2nd4 848 1 Side side JJ cord-009571-mygj2nd4 848 2 effects effect NNS cord-009571-mygj2nd4 848 3 occurred occur VBD cord-009571-mygj2nd4 848 4 significantly significantly RB cord-009571-mygj2nd4 848 5 more more RBR cord-009571-mygj2nd4 848 6 frequently frequently RB cord-009571-mygj2nd4 848 7 with with IN cord-009571-mygj2nd4 848 8 Pe Pe NNP cord-009571-mygj2nd4 848 9 , , , cord-009571-mygj2nd4 848 10 somewhat somewhat RB cord-009571-mygj2nd4 848 11 more more RBR cord-009571-mygj2nd4 848 12 often often RB cord-009571-mygj2nd4 848 13 with with IN cord-009571-mygj2nd4 848 14 Co Co NNP cord-009571-mygj2nd4 848 15 , , , cord-009571-mygj2nd4 848 16 but but CC cord-009571-mygj2nd4 848 17 were be VBD cord-009571-mygj2nd4 848 18 otherwise otherwise RB cord-009571-mygj2nd4 848 19 insignificant insignificant JJ cord-009571-mygj2nd4 848 20 . . . cord-009571-mygj2nd4 849 1 Effectiveness Effectiveness NNP cord-009571-mygj2nd4 849 2 was be VBD cord-009571-mygj2nd4 849 3 analyzed analyze VBN cord-009571-mygj2nd4 849 4 according accord VBG cord-009571-mygj2nd4 849 5 to to IN cord-009571-mygj2nd4 849 6 some some DT cord-009571-mygj2nd4 849 7 of of IN cord-009571-mygj2nd4 849 8 all all DT cord-009571-mygj2nd4 849 9 ranks rank NNS cord-009571-mygj2nd4 849 10 , , , cord-009571-mygj2nd4 849 11 mean mean VBP cord-009571-mygj2nd4 849 12 percent percent NN cord-009571-mygj2nd4 849 13 relief relief NN cord-009571-mygj2nd4 849 14 and and CC cord-009571-mygj2nd4 849 15 percent percent NN cord-009571-mygj2nd4 849 16 of of IN cord-009571-mygj2nd4 849 17 subjects subject NNS cord-009571-mygj2nd4 849 18 achieving achieve VBG cord-009571-mygj2nd4 849 19 50 50 CD cord-009571-mygj2nd4 849 20 % % NN cord-009571-mygj2nd4 849 21 or or CC cord-009571-mygj2nd4 849 22 greater great JJR cord-009571-mygj2nd4 849 23 relief relief NN cord-009571-mygj2nd4 849 24 for for IN cord-009571-mygj2nd4 849 25 each each DT cord-009571-mygj2nd4 849 26 agent agent NN cord-009571-mygj2nd4 849 27 . . . cord-009571-mygj2nd4 850 1 As as IN cord-009571-mygj2nd4 850 2 expected expect VBN cord-009571-mygj2nd4 850 3 , , , cord-009571-mygj2nd4 850 4 by by IN cord-009571-mygj2nd4 850 5 parameters parameter NNS cord-009571-mygj2nd4 850 6 measured measure VBN cord-009571-mygj2nd4 850 7 in in IN cord-009571-mygj2nd4 850 8 this this DT cord-009571-mygj2nd4 850 9 study study NN cord-009571-mygj2nd4 850 10 and and CC cord-009571-mygj2nd4 850 11 by by IN cord-009571-mygj2nd4 850 12 cost cost NN cord-009571-mygj2nd4 850 13 to to IN cord-009571-mygj2nd4 850 14 the the DT cord-009571-mygj2nd4 850 15 patient patient NN cord-009571-mygj2nd4 850 16 , , , cord-009571-mygj2nd4 850 17 ASA ASA NNP cord-009571-mygj2nd4 850 18 is be VBZ cord-009571-mygj2nd4 850 19 a a DT cord-009571-mygj2nd4 850 20 superior superior JJ cord-009571-mygj2nd4 850 21 analgetic analgetic JJ cord-009571-mygj2nd4 850 22 in in IN cord-009571-mygj2nd4 850 23 RA RA NNP cord-009571-mygj2nd4 850 24 . . . cord-009571-mygj2nd4 851 1 However however RB cord-009571-mygj2nd4 851 2 , , , cord-009571-mygj2nd4 851 3 Ac Ac NNP cord-009571-mygj2nd4 851 4 , , , cord-009571-mygj2nd4 851 5 by by IN cord-009571-mygj2nd4 851 6 cost cost NN cord-009571-mygj2nd4 851 7 and and CC cord-009571-mygj2nd4 851 8 effectiveness effectiveness NN cord-009571-mygj2nd4 851 9 , , , cord-009571-mygj2nd4 851 10 is be VBZ cord-009571-mygj2nd4 851 11 an an DT cord-009571-mygj2nd4 851 12 acceptable acceptable JJ cord-009571-mygj2nd4 851 13 alternative alternative NN cord-009571-mygj2nd4 851 14 , , , cord-009571-mygj2nd4 851 15 as as IN cord-009571-mygj2nd4 851 16 codeine codeine NN cord-009571-mygj2nd4 851 17 would would MD cord-009571-mygj2nd4 851 18 be be VB cord-009571-mygj2nd4 851 19 except except IN cord-009571-mygj2nd4 851 20 for for IN cord-009571-mygj2nd4 851 21 its -PRON- PRP$ cord-009571-mygj2nd4 851 22 narcotic narcotic JJ cord-009571-mygj2nd4 851 23 properties property NNS cord-009571-mygj2nd4 851 24 and and CC cord-009571-mygj2nd4 851 25 cost cost NN cord-009571-mygj2nd4 851 26 . . . cord-009571-mygj2nd4 852 1 Cost cost NN cord-009571-mygj2nd4 852 2 , , , cord-009571-mygj2nd4 852 3 side side NN cord-009571-mygj2nd4 852 4 effects effect NNS cord-009571-mygj2nd4 852 5 , , , cord-009571-mygj2nd4 852 6 and and CC cord-009571-mygj2nd4 852 7 limited limited JJ cord-009571-mygj2nd4 852 8 effectiveness effectiveness NN cord-009571-mygj2nd4 852 9 restrict restrict VBP cord-009571-mygj2nd4 852 10 the the DT cord-009571-mygj2nd4 852 11 usefulness usefulness NN cord-009571-mygj2nd4 852 12 of of IN cord-009571-mygj2nd4 852 13 Pe Pe NNP cord-009571-mygj2nd4 852 14 . . . cord-009571-mygj2nd4 853 1 Pro Pro NNP cord-009571-mygj2nd4 853 2 seems seem VBZ cord-009571-mygj2nd4 853 3 no no DT cord-009571-mygj2nd4 853 4 more more RBR cord-009571-mygj2nd4 853 5 effective effective JJ cord-009571-mygj2nd4 853 6 than than IN cord-009571-mygj2nd4 853 7 PI pi NN cord-009571-mygj2nd4 853 8 and and CC cord-009571-mygj2nd4 853 9 of of IN cord-009571-mygj2nd4 853 10 questionable questionable JJ cord-009571-mygj2nd4 853 11 usefulness usefulness NN cord-009571-mygj2nd4 853 12 in in IN cord-009571-mygj2nd4 853 13 RA RA NNP cord-009571-mygj2nd4 853 14 , , , cord-009571-mygj2nd4 853 15 except except IN cord-009571-mygj2nd4 853 16 perhaps perhaps RB cord-009571-mygj2nd4 853 17 as as IN cord-009571-mygj2nd4 853 18 a a DT cord-009571-mygj2nd4 853 19 placebo placebo NN cord-009571-mygj2nd4 853 20 . . . cord-009571-mygj2nd4 854 1 Sum Sum NNP cord-009571-mygj2nd4 854 2 _SP cord-009571-mygj2nd4 855 1 There there EX cord-009571-mygj2nd4 855 2 is be VBZ cord-009571-mygj2nd4 855 3 evidence evidence NN cord-009571-mygj2nd4 855 4 that that IN cord-009571-mygj2nd4 855 5 the the DT cord-009571-mygj2nd4 855 6 inflammatory inflammatory JJ cord-009571-mygj2nd4 855 7 properties property NNS cord-009571-mygj2nd4 855 8 of of IN cord-009571-mygj2nd4 855 9 crystalline crystalline JJ cord-009571-mygj2nd4 855 10 material material NN cord-009571-mygj2nd4 855 11 may may MD cord-009571-mygj2nd4 855 12 be be VB cord-009571-mygj2nd4 855 13 modified modify VBN cord-009571-mygj2nd4 855 14 by by IN cord-009571-mygj2nd4 855 15 their -PRON- PRP$ cord-009571-mygj2nd4 855 16 interaction interaction NN cord-009571-mygj2nd4 855 17 with with IN cord-009571-mygj2nd4 855 18 serum serum NN cord-009571-mygj2nd4 855 19 proteins protein NNS cord-009571-mygj2nd4 855 20 . . . cord-009571-mygj2nd4 856 1 In in IN cord-009571-mygj2nd4 856 2 this this DT cord-009571-mygj2nd4 856 3 study study NN cord-009571-mygj2nd4 856 4 , , , cord-009571-mygj2nd4 856 5 the the DT cord-009571-mygj2nd4 856 6 activation activation NN cord-009571-mygj2nd4 856 7 of of IN cord-009571-mygj2nd4 856 8 C3 C3 NNP cord-009571-mygj2nd4 856 9 by by IN cord-009571-mygj2nd4 856 10 crystals crystal NNS cord-009571-mygj2nd4 856 11 is be VBZ cord-009571-mygj2nd4 856 12 quantitated quantitate VBN cord-009571-mygj2nd4 856 13 by by IN cord-009571-mygj2nd4 856 14 two two CD cord-009571-mygj2nd4 856 15 dimensional dimensional JJ cord-009571-mygj2nd4 856 16 crossed crossed JJ cord-009571-mygj2nd4 856 17 immunoelectrophoresis immunoelectrophoresis NN cord-009571-mygj2nd4 856 18 ( ( -LRB- cord-009571-mygj2nd4 856 19 TDIEP TDIEP NNP cord-009571-mygj2nd4 856 20 ) ) -RRB- cord-009571-mygj2nd4 856 21 . . . cord-009571-mygj2nd4 857 1 In in IN cord-009571-mygj2nd4 857 2 polypropylene polypropylene JJ cord-009571-mygj2nd4 857 3 tubes tube NNS cord-009571-mygj2nd4 857 4 0.5 0.5 CD cord-009571-mygj2nd4 857 5 ml ml NN cord-009571-mygj2nd4 857 6 aliquots aliquot NNS cord-009571-mygj2nd4 857 7 of of IN cord-009571-mygj2nd4 857 8 fresh fresh JJ cord-009571-mygj2nd4 857 9 human human JJ cord-009571-mygj2nd4 857 10 serum serum NN cord-009571-mygj2nd4 857 11 were be VBD cord-009571-mygj2nd4 857 12 mixed mix VBN cord-009571-mygj2nd4 857 13 with with IN cord-009571-mygj2nd4 857 14 0.1 0.1 CD cord-009571-mygj2nd4 857 15 ml ml NNS cord-009571-mygj2nd4 857 16 of of IN cord-009571-mygj2nd4 857 17 buffer buffer NN cord-009571-mygj2nd4 857 18 containing contain VBG cord-009571-mygj2nd4 857 19 2.5 2.5 CD cord-009571-mygj2nd4 857 20 mg mg NNS cord-009571-mygj2nd4 857 21 of of IN cord-009571-mygj2nd4 857 22 washed wash VBN cord-009571-mygj2nd4 857 23 crystals crystal NNS cord-009571-mygj2nd4 857 24 . . . cord-009571-mygj2nd4 858 1 The the DT cord-009571-mygj2nd4 858 2 tubes tube NNS cord-009571-mygj2nd4 858 3 were be VBD cord-009571-mygj2nd4 858 4 incubated incubate VBN cord-009571-mygj2nd4 858 5 with with IN cord-009571-mygj2nd4 858 6 agitation agitation NN cord-009571-mygj2nd4 858 7 of of IN cord-009571-mygj2nd4 858 8 37OC 37oc CD cord-009571-mygj2nd4 858 9 for for IN cord-009571-mygj2nd4 858 10 1 1 CD cord-009571-mygj2nd4 858 11 hour hour NN cord-009571-mygj2nd4 858 12 and and CC cord-009571-mygj2nd4 858 13 then then RB cord-009571-mygj2nd4 858 14 centrifuged centrifuge VBN cord-009571-mygj2nd4 858 15 at at IN cord-009571-mygj2nd4 858 16 15,OOOg 15,ooog CD cord-009571-mygj2nd4 858 17 for for IN cord-009571-mygj2nd4 858 18 4 4 CD cord-009571-mygj2nd4 858 19 minutes minute NNS cord-009571-mygj2nd4 858 20 . . . cord-009571-mygj2nd4 859 1 Aliquots Aliquots NNP cord-009571-mygj2nd4 859 2 of of IN cord-009571-mygj2nd4 859 3 the the DT cord-009571-mygj2nd4 859 4 supernatants supernatant NNS cord-009571-mygj2nd4 859 5 were be VBD cord-009571-mygj2nd4 859 6 diluted dilute VBN cord-009571-mygj2nd4 859 7 appropriately appropriately RB cord-009571-mygj2nd4 859 8 in in IN cord-009571-mygj2nd4 859 9 EDTA EDTA NNP cord-009571-mygj2nd4 859 10 - - HYPH cord-009571-mygj2nd4 859 11 containing contain VBG cord-009571-mygj2nd4 859 12 buffer buffer NN cord-009571-mygj2nd4 859 13 to to IN cord-009571-mygj2nd4 859 14 inhibit inhibit VB cord-009571-mygj2nd4 859 15 further further JJ cord-009571-mygj2nd4 859 16 conversion conversion NN cord-009571-mygj2nd4 859 17 of of IN cord-009571-mygj2nd4 859 18 C3 c3 NN cord-009571-mygj2nd4 859 19 . . . cord-009571-mygj2nd4 860 1 By by IN cord-009571-mygj2nd4 860 2 use use NN cord-009571-mygj2nd4 860 3 of of IN cord-009571-mygj2nd4 860 4 standard standard JJ cord-009571-mygj2nd4 860 5 techniques technique NNS cord-009571-mygj2nd4 860 6 , , , cord-009571-mygj2nd4 860 7 TDIEP TDIEP NNP cord-009571-mygj2nd4 860 8 was be VBD cord-009571-mygj2nd4 860 9 performed perform VBN cord-009571-mygj2nd4 860 10 using use VBG cord-009571-mygj2nd4 860 11 rabbit rabbit NN cord-009571-mygj2nd4 860 12 antisera antisera NNP cord-009571-mygj2nd4 860 13 to to IN cord-009571-mygj2nd4 860 14 human human JJ cord-009571-mygj2nd4 860 15 C3 c3 NN cord-009571-mygj2nd4 860 16 . . . cord-009571-mygj2nd4 861 1 A a DT cord-009571-mygj2nd4 861 2 method method NN cord-009571-mygj2nd4 861 3 was be VBD cord-009571-mygj2nd4 861 4 devised devise VBN cord-009571-mygj2nd4 861 5 whereby whereby WRB cord-009571-mygj2nd4 861 6 6 6 CD cord-009571-mygj2nd4 861 7 samples sample NNS cord-009571-mygj2nd4 861 8 could could MD cord-009571-mygj2nd4 861 9 be be VB cord-009571-mygj2nd4 861 10 compared compare VBN cord-009571-mygj2nd4 861 11 simultaneously simultaneously RB cord-009571-mygj2nd4 861 12 on on IN cord-009571-mygj2nd4 861 13 a a DT cord-009571-mygj2nd4 861 14 single single JJ cord-009571-mygj2nd4 861 15 plate plate NN cord-009571-mygj2nd4 861 16 . . . cord-009571-mygj2nd4 862 1 After after IN cord-009571-mygj2nd4 862 2 staining stain VBG cord-009571-mygj2nd4 862 3 , , , cord-009571-mygj2nd4 862 4 the the DT cord-009571-mygj2nd4 862 5 combined combined JJ cord-009571-mygj2nd4 862 6 area area NN cord-009571-mygj2nd4 862 7 under under IN cord-009571-mygj2nd4 862 8 the the DT cord-009571-mygj2nd4 862 9 PIC PIC NNP cord-009571-mygj2nd4 862 10 and and CC cord-009571-mygj2nd4 862 11 BIA BIA NNP cord-009571-mygj2nd4 862 12 peaks peak NNS cord-009571-mygj2nd4 862 13 was be VBD cord-009571-mygj2nd4 862 14 measured measure VBN cord-009571-mygj2nd4 862 15 using use VBG cord-009571-mygj2nd4 862 16 planimetry planimetry NNP cord-009571-mygj2nd4 862 17 . . . cord-009571-mygj2nd4 863 1 The the DT cord-009571-mygj2nd4 863 2 numerical numerical JJ cord-009571-mygj2nd4 863 3 results result NNS cord-009571-mygj2nd4 863 4 below below RB cord-009571-mygj2nd4 863 5 are be VBP cord-009571-mygj2nd4 863 6 percentage percentage NN cord-009571-mygj2nd4 863 7 points point NNS cord-009571-mygj2nd4 863 8 of of IN cord-009571-mygj2nd4 863 9 total total JJ cord-009571-mygj2nd4 863 10 area area NN cord-009571-mygj2nd4 863 11 under under IN cord-009571-mygj2nd4 863 12 the the DT cord-009571-mygj2nd4 863 13 P1A p1a CD cord-009571-mygj2nd4 863 14 peak peak NN cord-009571-mygj2nd4 863 15 in in IN cord-009571-mygj2nd4 863 16 excess excess NN cord-009571-mygj2nd4 863 17 of of IN cord-009571-mygj2nd4 863 18 that that DT cord-009571-mygj2nd4 863 19 seen see VBN cord-009571-mygj2nd4 863 20 in in IN cord-009571-mygj2nd4 863 21 saline saline NN cord-009571-mygj2nd4 863 22 controls control NNS cord-009571-mygj2nd4 863 23 . . . cord-009571-mygj2nd4 864 1 The the DT cord-009571-mygj2nd4 864 2 coefficient coefficient NN cord-009571-mygj2nd4 864 3 of of IN cord-009571-mygj2nd4 864 4 variation variation NN cord-009571-mygj2nd4 864 5 of of IN cord-009571-mygj2nd4 864 6 the the DT cord-009571-mygj2nd4 864 7 ratio ratio NN cord-009571-mygj2nd4 864 8 of of IN cord-009571-mygj2nd4 864 9 the the DT cord-009571-mygj2nd4 864 10 two two CD cord-009571-mygj2nd4 864 11 peaks peak NNS cord-009571-mygj2nd4 864 12 was be VBD cord-009571-mygj2nd4 864 13 0.008 0.008 CD cord-009571-mygj2nd4 864 14 for for IN cord-009571-mygj2nd4 864 15 a a DT cord-009571-mygj2nd4 864 16 single single JJ cord-009571-mygj2nd4 864 17 specimen specimen NN cord-009571-mygj2nd4 864 18 on on IN cord-009571-mygj2nd4 864 19 the the DT cord-009571-mygj2nd4 864 20 same same JJ cord-009571-mygj2nd4 864 21 plate plate NN cord-009571-mygj2nd4 864 22 . . . cord-009571-mygj2nd4 865 1 The the DT cord-009571-mygj2nd4 865 2 areas area NNS cord-009571-mygj2nd4 865 3 could could MD cord-009571-mygj2nd4 865 4 be be VB cord-009571-mygj2nd4 865 5 corrected correct VBN cord-009571-mygj2nd4 865 6 to to TO cord-009571-mygj2nd4 865 7 indicate indicate VB cord-009571-mygj2nd4 865 8 milligrams milligram NNS cord-009571-mygj2nd4 865 9 of of IN cord-009571-mygj2nd4 865 10 C3 c3 NN cord-009571-mygj2nd4 865 11 converted convert VBN cord-009571-mygj2nd4 865 12 . . . cord-009571-mygj2nd4 866 1 Sodium sodium NN cord-009571-mygj2nd4 866 2 urate urate NN cord-009571-mygj2nd4 866 3 was be VBD cord-009571-mygj2nd4 866 4 highly highly RB cord-009571-mygj2nd4 866 5 active active JJ cord-009571-mygj2nd4 866 6 in in IN cord-009571-mygj2nd4 866 7 the the DT cord-009571-mygj2nd4 866 8 electrophoretic electrophoretic JJ cord-009571-mygj2nd4 866 9 conversion conversion NN cord-009571-mygj2nd4 866 10 of of IN cord-009571-mygj2nd4 866 11 C3 C3 NNP cord-009571-mygj2nd4 866 12 with with IN cord-009571-mygj2nd4 866 13 a a DT cord-009571-mygj2nd4 866 14 dose dose NN cord-009571-mygj2nd4 866 15 and and CC cord-009571-mygj2nd4 866 16 time time NN cord-009571-mygj2nd4 866 17 related related JJ cord-009571-mygj2nd4 866 18 response response NN cord-009571-mygj2nd4 866 19 . . . cord-009571-mygj2nd4 867 1 Activation activation NN cord-009571-mygj2nd4 867 2 was be VBD cord-009571-mygj2nd4 867 3 prominent prominent JJ cord-009571-mygj2nd4 867 4 a a DT cord-009571-mygj2nd4 867 5 t t NN cord-009571-mygj2nd4 867 6 concentrations concentration NNS cord-009571-mygj2nd4 867 7 of of IN cord-009571-mygj2nd4 867 8 crystals crystal NNS cord-009571-mygj2nd4 867 9 seen see VBN cord-009571-mygj2nd4 867 10 in in IN cord-009571-mygj2nd4 867 11 gouty gouty JJ cord-009571-mygj2nd4 867 12 effusions effusion NNS cord-009571-mygj2nd4 867 13 . . . cord-009571-mygj2nd4 868 1 Heating heat VBG cord-009571-mygj2nd4 868 2 the the DT cord-009571-mygj2nd4 868 3 crystals crystal NNS cord-009571-mygj2nd4 868 4 at at IN cord-009571-mygj2nd4 868 5 200 200 CD cord-009571-mygj2nd4 868 6 ' ' '' cord-009571-mygj2nd4 868 7 C c NN cord-009571-mygj2nd4 868 8 for for IN cord-009571-mygj2nd4 868 9 2 2 CD cord-009571-mygj2nd4 868 10 hours hour NNS cord-009571-mygj2nd4 868 11 reduced reduce VBN cord-009571-mygj2nd4 868 12 C3 c3 NN cord-009571-mygj2nd4 868 13 conversion conversion NN cord-009571-mygj2nd4 868 14 by by IN cord-009571-mygj2nd4 868 15 nine nine CD cord-009571-mygj2nd4 868 16 - - HYPH cord-009571-mygj2nd4 868 17 tenths tenth NNS cord-009571-mygj2nd4 868 18 , , , cord-009571-mygj2nd4 868 19 but but CC cord-009571-mygj2nd4 868 20 also also RB cord-009571-mygj2nd4 868 21 altered alter VBD cord-009571-mygj2nd4 868 22 morphologic morphologic JJ cord-009571-mygj2nd4 868 23 properties property NNS cord-009571-mygj2nd4 868 24 of of IN cord-009571-mygj2nd4 868 25 the the DT cord-009571-mygj2nd4 868 26 crystal crystal NN cord-009571-mygj2nd4 868 27 preparations preparation NNS cord-009571-mygj2nd4 868 28 . . . cord-009571-mygj2nd4 869 1 Conversion conversion NN cord-009571-mygj2nd4 869 2 was be VBD cord-009571-mygj2nd4 869 3 inhibited inhibit VBN cord-009571-mygj2nd4 869 4 by by IN cord-009571-mygj2nd4 869 5 increasing increase VBG cord-009571-mygj2nd4 869 6 concentrations concentration NNS cord-009571-mygj2nd4 869 7 of of IN cord-009571-mygj2nd4 869 8 EDTA EDTA NNP cord-009571-mygj2nd4 869 9 and and CC cord-009571-mygj2nd4 869 10 eliminated eliminate VBN cord-009571-mygj2nd4 869 11 by by IN cord-009571-mygj2nd4 869 12 0.005 0.005 CD cord-009571-mygj2nd4 869 13 M M NNP cord-009571-mygj2nd4 869 14 EDTA EDTA NNP cord-009571-mygj2nd4 869 15 . . . cord-009571-mygj2nd4 870 1 The the DT cord-009571-mygj2nd4 870 2 EDTA EDTA NNP cord-009571-mygj2nd4 870 3 inhibition inhibition NN cord-009571-mygj2nd4 870 4 was be VBD cord-009571-mygj2nd4 870 5 not not RB cord-009571-mygj2nd4 870 6 seen see VBN cord-009571-mygj2nd4 870 7 in in IN cord-009571-mygj2nd4 870 8 the the DT cord-009571-mygj2nd4 870 9 presence presence NN cord-009571-mygj2nd4 870 10 of of IN cord-009571-mygj2nd4 870 11 excess excess JJ cord-009571-mygj2nd4 870 12 calcium calcium NN cord-009571-mygj2nd4 870 13 . . . cord-009571-mygj2nd4 871 1 With with IN cord-009571-mygj2nd4 871 2 the the DT cord-009571-mygj2nd4 871 3 conditions condition NNS cord-009571-mygj2nd4 871 4 described describe VBN cord-009571-mygj2nd4 871 5 above above RB cord-009571-mygj2nd4 871 6 , , , cord-009571-mygj2nd4 871 7 potassium potassium NN cord-009571-mygj2nd4 871 8 urate urate NN cord-009571-mygj2nd4 871 9 crystals crystal NNS cord-009571-mygj2nd4 871 10 were be VBD cord-009571-mygj2nd4 871 11 much much RB cord-009571-mygj2nd4 871 12 less less RBR cord-009571-mygj2nd4 871 13 active active JJ cord-009571-mygj2nd4 871 14 ( ( -LRB- cord-009571-mygj2nd4 871 15 8 8 CD cord-009571-mygj2nd4 871 16 % % NN cord-009571-mygj2nd4 871 17 ) ) -RRB- cord-009571-mygj2nd4 871 18 than than IN cord-009571-mygj2nd4 871 19 sodium sodium NN cord-009571-mygj2nd4 871 20 urate urate NN cord-009571-mygj2nd4 871 21 ( ( -LRB- cord-009571-mygj2nd4 871 22 31 31 CD cord-009571-mygj2nd4 871 23 % % NN cord-009571-mygj2nd4 871 24 ) ) -RRB- cord-009571-mygj2nd4 871 25 . . . cord-009571-mygj2nd4 872 1 Eight eight CD cord-009571-mygj2nd4 872 2 different different JJ cord-009571-mygj2nd4 872 3 commercially commercially RB cord-009571-mygj2nd4 872 4 available available JJ cord-009571-mygj2nd4 872 5 preparations preparation NNS cord-009571-mygj2nd4 872 6 of of IN cord-009571-mygj2nd4 872 7 steroids steroid NNS cord-009571-mygj2nd4 872 8 gave give VBD cord-009571-mygj2nd4 872 9 varying vary VBG cord-009571-mygj2nd4 872 10 but but CC cord-009571-mygj2nd4 872 11 small small JJ cord-009571-mygj2nd4 872 12 amounts amount NNS cord-009571-mygj2nd4 872 13 of of IN cord-009571-mygj2nd4 872 14 C3 c3 NN cord-009571-mygj2nd4 872 15 activation activation NN cord-009571-mygj2nd4 872 16 ( ( -LRB- cord-009571-mygj2nd4 872 17 -1 -1 CC cord-009571-mygj2nd4 872 18 t t NNP cord-009571-mygj2nd4 872 19 o o NN cord-009571-mygj2nd4 872 20 5 5 CD cord-009571-mygj2nd4 872 21 % % NN cord-009571-mygj2nd4 872 22 ) ) -RRB- cord-009571-mygj2nd4 872 23 . . . cord-009571-mygj2nd4 873 1 It -PRON- PRP cord-009571-mygj2nd4 873 2 is be VBZ cord-009571-mygj2nd4 873 3 demonstrated demonstrate VBN cord-009571-mygj2nd4 873 4 that that IN cord-009571-mygj2nd4 873 5 different different JJ cord-009571-mygj2nd4 873 6 crystals crystal NNS cord-009571-mygj2nd4 873 7 and and CC cord-009571-mygj2nd4 873 8 altered altered JJ cord-009571-mygj2nd4 873 9 forms form NNS cord-009571-mygj2nd4 873 10 of of IN cord-009571-mygj2nd4 873 11 the the DT cord-009571-mygj2nd4 873 12 same same JJ cord-009571-mygj2nd4 873 13 crystals crystal NNS cord-009571-mygj2nd4 873 14 vary vary VBP cord-009571-mygj2nd4 873 15 in in IN cord-009571-mygj2nd4 873 16 their -PRON- PRP$ cord-009571-mygj2nd4 873 17 interaction interaction NN cord-009571-mygj2nd4 873 18 with with IN cord-009571-mygj2nd4 873 19 serum serum NN cord-009571-mygj2nd4 873 20 and and CC cord-009571-mygj2nd4 873 21 their -PRON- PRP$ cord-009571-mygj2nd4 873 22 ability ability NN cord-009571-mygj2nd4 873 23 to to TO cord-009571-mygj2nd4 873 24 activate activate VB cord-009571-mygj2nd4 873 25 complement complement NN cord-009571-mygj2nd4 873 26 . . . cord-009571-mygj2nd4 874 1 It -PRON- PRP cord-009571-mygj2nd4 874 2 is be VBZ cord-009571-mygj2nd4 874 3 not not RB cord-009571-mygj2nd4 874 4 known know VBN cord-009571-mygj2nd4 874 5 what what WDT cord-009571-mygj2nd4 874 6 properties property NNS cord-009571-mygj2nd4 874 7 are be VBP cord-009571-mygj2nd4 874 8 responsible responsible JJ cord-009571-mygj2nd4 874 9 for for IN cord-009571-mygj2nd4 874 10 these these DT cord-009571-mygj2nd4 874 11 phenomena phenomenon NNS cord-009571-mygj2nd4 874 12 . . . cord-009571-mygj2nd4 875 1 The the DT cord-009571-mygj2nd4 875 2 calcium calcium NN cord-009571-mygj2nd4 875 3 requirement requirement NN cord-009571-mygj2nd4 875 4 suggests suggest VBZ cord-009571-mygj2nd4 875 5 that that IN cord-009571-mygj2nd4 875 6 the the DT cord-009571-mygj2nd4 875 7 interaction interaction NN cord-009571-mygj2nd4 875 8 of of IN cord-009571-mygj2nd4 875 9 sodium sodium NN cord-009571-mygj2nd4 875 10 urate urate NN cord-009571-mygj2nd4 875 11 with with IN cord-009571-mygj2nd4 875 12 complement complement NN cord-009571-mygj2nd4 875 13 occurs occur VBZ cord-009571-mygj2nd4 875 14 at at IN cord-009571-mygj2nd4 875 15 or or CC cord-009571-mygj2nd4 875 16 before before IN cord-009571-mygj2nd4 875 17 C1 C1 NNP cord-009571-mygj2nd4 875 18 . . . cord-009571-mygj2nd4 876 1 It -PRON- PRP cord-009571-mygj2nd4 876 2 is be VBZ cord-009571-mygj2nd4 876 3 possible possible JJ cord-009571-mygj2nd4 876 4 that that IN cord-009571-mygj2nd4 876 5 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 876 6 , , , cord-009571-mygj2nd4 876 7 which which WDT cord-009571-mygj2nd4 876 8 has have VBZ cord-009571-mygj2nd4 876 9 a a DT cord-009571-mygj2nd4 876 10 high high JJ cord-009571-mygj2nd4 876 11 affinity affinity NN cord-009571-mygj2nd4 876 12 for for IN cord-009571-mygj2nd4 876 13 sodium sodium NN cord-009571-mygj2nd4 876 14 urate urate NN cord-009571-mygj2nd4 876 15 and and CC cord-009571-mygj2nd4 876 16 is be VBZ cord-009571-mygj2nd4 876 17 found find VBN cord-009571-mygj2nd4 876 18 in in IN cord-009571-mygj2nd4 876 19 sodium sodium NN cord-009571-mygj2nd4 876 20 urate urate NN cord-009571-mygj2nd4 876 21 crystals crystal NNS cord-009571-mygj2nd4 876 22 in in IN cord-009571-mygj2nd4 876 23 vivo vivo NN cord-009571-mygj2nd4 876 24 , , , cord-009571-mygj2nd4 876 25 is be VBZ cord-009571-mygj2nd4 876 26 altered alter VBN cord-009571-mygj2nd4 876 27 and and CC cord-009571-mygj2nd4 876 28 initiates initiate VBZ cord-009571-mygj2nd4 876 29 complement complement JJ cord-009571-mygj2nd4 876 30 activation activation NN cord-009571-mygj2nd4 876 31 by by IN cord-009571-mygj2nd4 876 32 the the DT cord-009571-mygj2nd4 876 33 classic classic JJ cord-009571-mygj2nd4 876 34 pathway pathway NN cord-009571-mygj2nd4 876 35 . . . cord-009571-mygj2nd4 877 1 Temporal temporal JJ cord-009571-mygj2nd4 877 2 artery artery NN cord-009571-mygj2nd4 877 3 pain pain NN cord-009571-mygj2nd4 877 4 , , , cord-009571-mygj2nd4 877 5 polymyalgia polymyalgia NNP cord-009571-mygj2nd4 877 6 rheumatica rheumatica NNP cord-009571-mygj2nd4 877 7 , , , cord-009571-mygj2nd4 877 8 and and CC cord-009571-mygj2nd4 877 9 blindness blindness NN cord-009571-mygj2nd4 877 10 are be VBP cord-009571-mygj2nd4 877 11 well well RB cord-009571-mygj2nd4 877 12 recognized recognize VBN cord-009571-mygj2nd4 877 13 manifestations manifestation NNS cord-009571-mygj2nd4 877 14 of of IN cord-009571-mygj2nd4 877 15 giant giant JJ cord-009571-mygj2nd4 877 16 cell cell NN cord-009571-mygj2nd4 877 17 arteritis arteritis NN cord-009571-mygj2nd4 877 18 . . . cord-009571-mygj2nd4 878 1 However however RB cord-009571-mygj2nd4 878 2 , , , cord-009571-mygj2nd4 878 3 the the DT cord-009571-mygj2nd4 878 4 disease disease NN cord-009571-mygj2nd4 878 5 may may MD cord-009571-mygj2nd4 878 6 often often RB cord-009571-mygj2nd4 878 7 present present VB cord-009571-mygj2nd4 878 8 in in IN cord-009571-mygj2nd4 878 9 a a DT cord-009571-mygj2nd4 878 10 less less RBR cord-009571-mygj2nd4 878 11 evident evident JJ cord-009571-mygj2nd4 878 12 fashion fashion NN cord-009571-mygj2nd4 878 13 . . . cord-009571-mygj2nd4 879 1 This this DT cord-009571-mygj2nd4 879 2 is be VBZ cord-009571-mygj2nd4 879 3 demonstrated demonstrate VBN cord-009571-mygj2nd4 879 4 by by IN cord-009571-mygj2nd4 879 5 22 22 CD cord-009571-mygj2nd4 879 6 ( ( -LRB- cord-009571-mygj2nd4 879 7 39 39 CD cord-009571-mygj2nd4 879 8 % % NN cord-009571-mygj2nd4 879 9 ) ) -RRB- cord-009571-mygj2nd4 879 10 of of IN cord-009571-mygj2nd4 879 11 our -PRON- PRP$ cord-009571-mygj2nd4 879 12 series series NN cord-009571-mygj2nd4 879 13 of of IN cord-009571-mygj2nd4 879 14 patients patient NNS cord-009571-mygj2nd4 879 15 . . . cord-009571-mygj2nd4 880 1 Of of IN cord-009571-mygj2nd4 880 2 56 56 CD cord-009571-mygj2nd4 880 3 patients patient NNS cord-009571-mygj2nd4 880 4 with with IN cord-009571-mygj2nd4 880 5 biopsy biopsy NN cord-009571-mygj2nd4 880 6 - - HYPH cord-009571-mygj2nd4 880 7 proved prove VBN cord-009571-mygj2nd4 880 8 giant giant JJ cord-009571-mygj2nd4 880 9 cell cell NN cord-009571-mygj2nd4 880 10 arteritis arteritis NN cord-009571-mygj2nd4 880 11 , , , cord-009571-mygj2nd4 880 12 the the DT cord-009571-mygj2nd4 880 13 chief chief JJ cord-009571-mygj2nd4 880 14 complaint complaint NN cord-009571-mygj2nd4 880 15 was be VBD cord-009571-mygj2nd4 880 16 polymyalgia polymyalgia NNP cord-009571-mygj2nd4 880 17 rheurnatica rheurnatica NNP cord-009571-mygj2nd4 880 18 in in IN cord-009571-mygj2nd4 880 19 17 17 CD cord-009571-mygj2nd4 880 20 ; ; : cord-009571-mygj2nd4 880 21 temporal temporal JJ cord-009571-mygj2nd4 880 22 pain pain NN cord-009571-mygj2nd4 880 23 in in IN cord-009571-mygj2nd4 880 24 15 15 CD cord-009571-mygj2nd4 880 25 , , , cord-009571-mygj2nd4 880 26 and and CC cord-009571-mygj2nd4 880 27 loss loss NN cord-009571-mygj2nd4 880 28 of of IN cord-009571-mygj2nd4 880 29 vision vision NN cord-009571-mygj2nd4 880 30 in in IN cord-009571-mygj2nd4 880 31 2 2 CD cord-009571-mygj2nd4 880 32 . . . cord-009571-mygj2nd4 881 1 In in IN cord-009571-mygj2nd4 881 2 the the DT cord-009571-mygj2nd4 881 3 remaining remain VBG cord-009571-mygj2nd4 881 4 22 22 CD cord-009571-mygj2nd4 881 5 patients patient NNS cord-009571-mygj2nd4 881 6 , , , cord-009571-mygj2nd4 881 7 the the DT cord-009571-mygj2nd4 881 8 predominant predominant JJ cord-009571-mygj2nd4 881 9 complaint complaint NN cord-009571-mygj2nd4 881 10 that that WDT cord-009571-mygj2nd4 881 11 brought bring VBD cord-009571-mygj2nd4 881 12 them -PRON- PRP cord-009571-mygj2nd4 881 13 to to IN cord-009571-mygj2nd4 881 14 the the DT cord-009571-mygj2nd4 881 15 physician physician NN cord-009571-mygj2nd4 881 16 did do VBD cord-009571-mygj2nd4 881 17 not not RB cord-009571-mygj2nd4 881 18 suggest suggest VB cord-009571-mygj2nd4 881 19 the the DT cord-009571-mygj2nd4 881 20 diagnosis diagnosis NN cord-009571-mygj2nd4 881 21 of of IN cord-009571-mygj2nd4 881 22 giant giant JJ cord-009571-mygj2nd4 881 23 cell cell NN cord-009571-mygj2nd4 881 24 arteritis arteritis NN cord-009571-mygj2nd4 881 25 , , , cord-009571-mygj2nd4 881 26 since since IN cord-009571-mygj2nd4 881 27 headache headache NN cord-009571-mygj2nd4 881 28 and and CC cord-009571-mygj2nd4 881 29 polymyalgia polymyalgia NN cord-009571-mygj2nd4 881 30 were be VBD cord-009571-mygj2nd4 881 31 either either CC cord-009571-mygj2nd4 881 32 absent absent JJ cord-009571-mygj2nd4 881 33 or or CC cord-009571-mygj2nd4 881 34 so so RB cord-009571-mygj2nd4 881 35 minimal minimal JJ cord-009571-mygj2nd4 881 36 as as IN cord-009571-mygj2nd4 881 37 to to TO cord-009571-mygj2nd4 881 38 escape escape VB cord-009571-mygj2nd4 881 39 notice notice NN cord-009571-mygj2nd4 881 40 . . . cord-009571-mygj2nd4 882 1 These these DT cord-009571-mygj2nd4 882 2 complaints complaint NNS cord-009571-mygj2nd4 882 3 included include VBD cord-009571-mygj2nd4 882 4 fever fever NN cord-009571-mygj2nd4 882 5 of of IN cord-009571-mygj2nd4 882 6 unknown unknown JJ cord-009571-mygj2nd4 882 7 origin origin NN cord-009571-mygj2nd4 882 8 in in IN cord-009571-mygj2nd4 882 9 6 6 CD cord-009571-mygj2nd4 882 10 patients patient NNS cord-009571-mygj2nd4 882 11 ; ; : cord-009571-mygj2nd4 882 12 malaise malaise NN cord-009571-mygj2nd4 882 13 , , , cord-009571-mygj2nd4 882 14 anorexia anorexia NN cord-009571-mygj2nd4 882 15 , , , cord-009571-mygj2nd4 882 16 weight weight NN cord-009571-mygj2nd4 882 17 loss loss NN cord-009571-mygj2nd4 882 18 , , , cord-009571-mygj2nd4 882 19 and and CC cord-009571-mygj2nd4 882 20 abnormal abnormal JJ cord-009571-mygj2nd4 882 21 liver liver NN cord-009571-mygj2nd4 882 22 function function NN cord-009571-mygj2nd4 882 23 tests test NNS cord-009571-mygj2nd4 882 24 suggesting suggest VBG cord-009571-mygj2nd4 882 25 occult occult JJ cord-009571-mygj2nd4 882 26 malignancy malignancy NN cord-009571-mygj2nd4 882 27 in in IN cord-009571-mygj2nd4 882 28 6 6 CD cord-009571-mygj2nd4 882 29 ; ; : cord-009571-mygj2nd4 882 30 and and CC cord-009571-mygj2nd4 882 31 unexplained unexplained JJ cord-009571-mygj2nd4 882 32 anemia anemia NN cord-009571-mygj2nd4 882 33 in in IN cord-009571-mygj2nd4 882 34 2 2 CD cord-009571-mygj2nd4 882 35 . . . cord-009571-mygj2nd4 883 1 Four four CD cord-009571-mygj2nd4 883 2 patients patient NNS cord-009571-mygj2nd4 883 3 presented present VBN cord-009571-mygj2nd4 883 4 with with IN cord-009571-mygj2nd4 883 5 a a DT cord-009571-mygj2nd4 883 6 neurologic neurologic JJ cord-009571-mygj2nd4 883 7 syndrome syndrome NN cord-009571-mygj2nd4 883 8 ; ; : cord-009571-mygj2nd4 883 9 2 2 CD cord-009571-mygj2nd4 883 10 had have VBD cord-009571-mygj2nd4 883 11 diplopia diplopia VBN cord-009571-mygj2nd4 883 12 and and CC cord-009571-mygj2nd4 883 13 2 2 CD cord-009571-mygj2nd4 883 14 acute acute JJ cord-009571-mygj2nd4 883 15 weakness weakness NN cord-009571-mygj2nd4 883 16 of of IN cord-009571-mygj2nd4 883 17 one one CD cord-009571-mygj2nd4 883 18 arm arm NN cord-009571-mygj2nd4 883 19 . . . cord-009571-mygj2nd4 884 1 Claudication Claudication NNP cord-009571-mygj2nd4 884 2 was be VBD cord-009571-mygj2nd4 884 3 the the DT cord-009571-mygj2nd4 884 4 chief chief JJ cord-009571-mygj2nd4 884 5 complaint complaint NN cord-009571-mygj2nd4 884 6 of of IN cord-009571-mygj2nd4 884 7 4 4 CD cord-009571-mygj2nd4 884 8 patients patient NNS cord-009571-mygj2nd4 884 9 , , , cord-009571-mygj2nd4 884 10 involving involve VBG cord-009571-mygj2nd4 884 11 the the DT cord-009571-mygj2nd4 884 12 leg leg NN cord-009571-mygj2nd4 884 13 in in IN cord-009571-mygj2nd4 884 14 one one CD cord-009571-mygj2nd4 884 15 , , , cord-009571-mygj2nd4 884 16 the the DT cord-009571-mygj2nd4 884 17 arm arm NN cord-009571-mygj2nd4 884 18 in in IN cord-009571-mygj2nd4 884 19 one one CD cord-009571-mygj2nd4 884 20 , , , cord-009571-mygj2nd4 884 21 and and CC cord-009571-mygj2nd4 884 22 the the DT cord-009571-mygj2nd4 884 23 jaw jaw NN cord-009571-mygj2nd4 884 24 in in IN cord-009571-mygj2nd4 884 25 2 2 CD cord-009571-mygj2nd4 884 26 . . . cord-009571-mygj2nd4 885 1 All all DT cord-009571-mygj2nd4 885 2 patients patient NNS cord-009571-mygj2nd4 885 3 responded respond VBD cord-009571-mygj2nd4 885 4 well well RB cord-009571-mygj2nd4 885 5 t t NNP cord-009571-mygj2nd4 885 6 o o NN cord-009571-mygj2nd4 885 7 steroid steroid NN cord-009571-mygj2nd4 885 8 therapy therapy NN cord-009571-mygj2nd4 885 9 . . . cord-009571-mygj2nd4 886 1 The the DT cord-009571-mygj2nd4 886 2 diagnosis diagnosis NN cord-009571-mygj2nd4 886 3 of of IN cord-009571-mygj2nd4 886 4 giant giant JJ cord-009571-mygj2nd4 886 5 cell cell NN cord-009571-mygj2nd4 886 6 arteritis arteritis NN cord-009571-mygj2nd4 886 7 in in IN cord-009571-mygj2nd4 886 8 patients patient NNS cord-009571-mygj2nd4 886 9 such such JJ cord-009571-mygj2nd4 886 10 as as IN cord-009571-mygj2nd4 886 11 this this DT cord-009571-mygj2nd4 886 12 who who WP cord-009571-mygj2nd4 886 13 do do VBP cord-009571-mygj2nd4 886 14 not not RB cord-009571-mygj2nd4 886 15 present present VB cord-009571-mygj2nd4 886 16 in in IN cord-009571-mygj2nd4 886 17 typical typical JJ cord-009571-mygj2nd4 886 18 fashion fashion NN cord-009571-mygj2nd4 886 19 depends depend VBZ cord-009571-mygj2nd4 886 20 on on IN cord-009571-mygj2nd4 886 21 detection detection NN cord-009571-mygj2nd4 886 22 of of IN cord-009571-mygj2nd4 886 23 a a DT cord-009571-mygj2nd4 886 24 very very RB cord-009571-mygj2nd4 886 25 rapid rapid JJ cord-009571-mygj2nd4 886 26 erythrocyte erythrocyte NN cord-009571-mygj2nd4 886 27 sedimentation sedimentation NN cord-009571-mygj2nd4 886 28 rate rate NN cord-009571-mygj2nd4 886 29 , , , cord-009571-mygj2nd4 886 30 biopsy biopsy NN cord-009571-mygj2nd4 886 31 of of IN cord-009571-mygj2nd4 886 32 a a DT cord-009571-mygj2nd4 886 33 temporal temporal JJ cord-009571-mygj2nd4 886 34 artery artery NN cord-009571-mygj2nd4 886 35 , , , cord-009571-mygj2nd4 886 36 and and CC cord-009571-mygj2nd4 886 37 the the DT cord-009571-mygj2nd4 886 38 awareness awareness NN cord-009571-mygj2nd4 886 39 that that WDT cord-009571-mygj2nd4 886 40 the the DT cord-009571-mygj2nd4 886 41 disease disease NN cord-009571-mygj2nd4 886 42 may may MD cord-009571-mygj2nd4 886 43 manifest manifest VB cord-009571-mygj2nd4 886 44 itself -PRON- PRP cord-009571-mygj2nd4 886 45 in in IN cord-009571-mygj2nd4 886 46 a a DT cord-009571-mygj2nd4 886 47 variety variety NN cord-009571-mygj2nd4 886 48 of of IN cord-009571-mygj2nd4 886 49 ways way NNS cord-009571-mygj2nd4 886 50 . . . cord-009571-mygj2nd4 887 1 The the DT cord-009571-mygj2nd4 887 2 administration administration NN cord-009571-mygj2nd4 887 3 of of IN cord-009571-mygj2nd4 887 4 certain certain JJ cord-009571-mygj2nd4 887 5 drugs drug NNS cord-009571-mygj2nd4 887 6 induces induce VBZ cord-009571-mygj2nd4 887 7 clinical clinical JJ cord-009571-mygj2nd4 887 8 and and CC cord-009571-mygj2nd4 887 9 laboratory laboratory NN cord-009571-mygj2nd4 887 10 features feature NNS cord-009571-mygj2nd4 887 11 of of IN cord-009571-mygj2nd4 887 12 systemic systemic JJ cord-009571-mygj2nd4 887 13 lupus lupus NN cord-009571-mygj2nd4 887 14 erythematosus erythematosus NN cord-009571-mygj2nd4 887 15 ( ( -LRB- cord-009571-mygj2nd4 887 16 SLE SLE NNP cord-009571-mygj2nd4 887 17 ) ) -RRB- cord-009571-mygj2nd4 887 18 in in IN cord-009571-mygj2nd4 887 19 man man NN cord-009571-mygj2nd4 887 20 but but CC cord-009571-mygj2nd4 887 21 few few JJ cord-009571-mygj2nd4 887 22 studies study NNS cord-009571-mygj2nd4 887 23 of of IN cord-009571-mygj2nd4 887 24 this this DT cord-009571-mygj2nd4 887 25 human human JJ cord-009571-mygj2nd4 887 26 disease disease NN cord-009571-mygj2nd4 887 27 model model NN cord-009571-mygj2nd4 887 28 have have VBP cord-009571-mygj2nd4 887 29 been be VBN cord-009571-mygj2nd4 887 30 undertaken undertake VBN cord-009571-mygj2nd4 887 31 . . . cord-009571-mygj2nd4 888 1 Hydralazine Hydralazine NNP cord-009571-mygj2nd4 888 2 , , , cord-009571-mygj2nd4 888 3 a a DT cord-009571-mygj2nd4 888 4 useful useful JJ cord-009571-mygj2nd4 888 5 antihypertensive antihypertensive JJ cord-009571-mygj2nd4 888 6 agent agent NN cord-009571-mygj2nd4 888 7 , , , cord-009571-mygj2nd4 888 8 is be VBZ cord-009571-mygj2nd4 888 9 one one CD cord-009571-mygj2nd4 888 10 of of IN cord-009571-mygj2nd4 888 11 these these DT cord-009571-mygj2nd4 888 12 drugs drug NNS cord-009571-mygj2nd4 888 13 and and CC cord-009571-mygj2nd4 888 14 has have VBZ cord-009571-mygj2nd4 888 15 acquired acquire VBN cord-009571-mygj2nd4 888 16 a a DT cord-009571-mygj2nd4 888 17 " " `` cord-009571-mygj2nd4 888 18 bad bad JJ cord-009571-mygj2nd4 888 19 press press NN cord-009571-mygj2nd4 888 20 " " '' cord-009571-mygj2nd4 888 21 because because IN cord-009571-mygj2nd4 888 22 of of IN cord-009571-mygj2nd4 888 23 such such JJ cord-009571-mygj2nd4 888 24 observations observation NNS cord-009571-mygj2nd4 888 25 . . . cord-009571-mygj2nd4 889 1 A a DT cord-009571-mygj2nd4 889 2 prospective prospective JJ cord-009571-mygj2nd4 889 3 study study NN cord-009571-mygj2nd4 889 4 of of IN cord-009571-mygj2nd4 889 5 25 25 CD cord-009571-mygj2nd4 889 6 hypertensive hypertensive JJ cord-009571-mygj2nd4 889 7 patients patient NNS cord-009571-mygj2nd4 889 8 with with IN cord-009571-mygj2nd4 889 9 age age NN cord-009571-mygj2nd4 889 10 , , , cord-009571-mygj2nd4 889 11 sex sex NN cord-009571-mygj2nd4 889 12 , , , cord-009571-mygj2nd4 889 13 and and CC cord-009571-mygj2nd4 889 14 race race NN cord-009571-mygj2nd4 889 15 matched match VBN cord-009571-mygj2nd4 889 16 controls control NNS cord-009571-mygj2nd4 889 17 was be VBD cord-009571-mygj2nd4 889 18 begun begin VBN cord-009571-mygj2nd4 889 19 3 3 CD cord-009571-mygj2nd4 889 20 years year NNS cord-009571-mygj2nd4 889 21 ago ago RB cord-009571-mygj2nd4 889 22 . . . cord-009571-mygj2nd4 890 1 All all DT cord-009571-mygj2nd4 890 2 subjects subject NNS cord-009571-mygj2nd4 890 3 had have VBD cord-009571-mygj2nd4 890 4 complete complete JJ cord-009571-mygj2nd4 890 5 clinical clinical JJ cord-009571-mygj2nd4 890 6 examinations examination NNS cord-009571-mygj2nd4 890 7 ; ; : cord-009571-mygj2nd4 890 8 ANF ANF NNP cord-009571-mygj2nd4 890 9 , , , cord-009571-mygj2nd4 890 10 D D NNP cord-009571-mygj2nd4 890 11 N N NNP cord-009571-mygj2nd4 890 12 A A NNP cord-009571-mygj2nd4 890 13 binding binding NN cord-009571-mygj2nd4 890 14 ; ; : cord-009571-mygj2nd4 890 15 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 890 16 and and CC cord-009571-mygj2nd4 890 17 complement complement JJ cord-009571-mygj2nd4 890 18 levels level NNS cord-009571-mygj2nd4 890 19 ; ; : cord-009571-mygj2nd4 890 20 skin skin NN cord-009571-mygj2nd4 890 21 tests test NNS cord-009571-mygj2nd4 890 22 to to IN cord-009571-mygj2nd4 890 23 a a DT cord-009571-mygj2nd4 890 24 battery battery NN cord-009571-mygj2nd4 890 25 of of IN cord-009571-mygj2nd4 890 26 antigens antigen NNS cord-009571-mygj2nd4 890 27 and and CC cord-009571-mygj2nd4 890 28 lymphoprolifera lymphoprolifera JJ cord-009571-mygj2nd4 890 29 - - HYPH cord-009571-mygj2nd4 890 30 tive tive JJ cord-009571-mygj2nd4 890 31 responses response NNS cord-009571-mygj2nd4 891 1 t t NNP cord-009571-mygj2nd4 892 1 o o UH cord-009571-mygj2nd4 892 2 mitogens mitogens NNP cord-009571-mygj2nd4 892 3 and and CC cord-009571-mygj2nd4 892 4 antigens antigen NNS cord-009571-mygj2nd4 892 5 obtained obtain VBN cord-009571-mygj2nd4 892 6 prior prior RB cord-009571-mygj2nd4 892 7 t t NNP cord-009571-mygj2nd4 892 8 o o NN cord-009571-mygj2nd4 892 9 starting start VBG cord-009571-mygj2nd4 892 10 hydralazine hydralazine NNP cord-009571-mygj2nd4 892 11 and and CC cord-009571-mygj2nd4 892 12 serially serially RB cord-009571-mygj2nd4 892 13 throughout throughout IN cord-009571-mygj2nd4 892 14 the the DT cord-009571-mygj2nd4 892 15 study study NN cord-009571-mygj2nd4 892 16 . . . cord-009571-mygj2nd4 893 1 All all DT cord-009571-mygj2nd4 893 2 subjects subject NNS cord-009571-mygj2nd4 893 3 were be VBD cord-009571-mygj2nd4 893 4 A a DT cord-009571-mygj2nd4 893 5 N N NNP cord-009571-mygj2nd4 893 6 F F NNP cord-009571-mygj2nd4 893 7 negative negative JJ cord-009571-mygj2nd4 893 8 at at IN cord-009571-mygj2nd4 893 9 the the DT cord-009571-mygj2nd4 893 10 start start NN cord-009571-mygj2nd4 893 11 of of IN cord-009571-mygj2nd4 893 12 treatment treatment NN cord-009571-mygj2nd4 893 13 . . . cord-009571-mygj2nd4 894 1 Fifteen fifteen CD cord-009571-mygj2nd4 894 2 of of IN cord-009571-mygj2nd4 894 3 the the DT cord-009571-mygj2nd4 894 4 25 25 CD cord-009571-mygj2nd4 894 5 have have VBP cord-009571-mygj2nd4 894 6 shown show VBN cord-009571-mygj2nd4 894 7 varying vary VBG cord-009571-mygj2nd4 894 8 A a DT cord-009571-mygj2nd4 894 9 N N NNP cord-009571-mygj2nd4 894 10 F F NNP cord-009571-mygj2nd4 894 11 response response NN cord-009571-mygj2nd4 894 12 ( ( -LRB- cord-009571-mygj2nd4 894 13 in in IN cord-009571-mygj2nd4 894 14 undiluted undiluted JJ cord-009571-mygj2nd4 894 15 serum serum NN cord-009571-mygj2nd4 894 16 ) ) -RRB- cord-009571-mygj2nd4 894 17 but but CC cord-009571-mygj2nd4 894 18 only only RB cord-009571-mygj2nd4 894 19 3 3 CD cord-009571-mygj2nd4 894 20 had have VBD cord-009571-mygj2nd4 894 21 a a DT cord-009571-mygj2nd4 894 22 titer titer NN cord-009571-mygj2nd4 894 23 of of IN cord-009571-mygj2nd4 894 24 1 1 CD cord-009571-mygj2nd4 894 25 : : : cord-009571-mygj2nd4 894 26 lO lO NNP cord-009571-mygj2nd4 894 27 or or CC cord-009571-mygj2nd4 894 28 above above RB cord-009571-mygj2nd4 894 29 , , , cord-009571-mygj2nd4 894 30 one one CD cord-009571-mygj2nd4 894 31 becoming become VBG cord-009571-mygj2nd4 894 32 positive positive JJ cord-009571-mygj2nd4 894 33 at at IN cord-009571-mygj2nd4 894 34 12 12 CD cord-009571-mygj2nd4 894 35 months month NNS cord-009571-mygj2nd4 894 36 and and CC cord-009571-mygj2nd4 894 37 2 2 CD cord-009571-mygj2nd4 894 38 at at IN cord-009571-mygj2nd4 894 39 24 24 CD cord-009571-mygj2nd4 894 40 months month NNS cord-009571-mygj2nd4 894 41 . . . cord-009571-mygj2nd4 895 1 One one CD cord-009571-mygj2nd4 895 2 of of IN cord-009571-mygj2nd4 895 3 these these DT cord-009571-mygj2nd4 895 4 subjects subject NNS cord-009571-mygj2nd4 895 5 had have VBD cord-009571-mygj2nd4 895 6 clinical clinical JJ cord-009571-mygj2nd4 895 7 symptoms symptom NNS cord-009571-mygj2nd4 895 8 suggestive suggestive JJ cord-009571-mygj2nd4 895 9 of of IN cord-009571-mygj2nd4 895 10 SLE SLE NNP cord-009571-mygj2nd4 895 11 and and CC cord-009571-mygj2nd4 895 12 the the DT cord-009571-mygj2nd4 895 13 drug drug NN cord-009571-mygj2nd4 895 14 was be VBD cord-009571-mygj2nd4 895 15 stopped stop VBN cord-009571-mygj2nd4 895 16 . . . cord-009571-mygj2nd4 896 1 Five five CD cord-009571-mygj2nd4 896 2 subjects subject NNS cord-009571-mygj2nd4 896 3 have have VBP cord-009571-mygj2nd4 896 4 shown show VBN cord-009571-mygj2nd4 896 5 a a DT cord-009571-mygj2nd4 896 6 proliferative proliferative JJ cord-009571-mygj2nd4 896 7 lymphocyte lymphocyte NN cord-009571-mygj2nd4 896 8 response response NN cord-009571-mygj2nd4 896 9 to to IN cord-009571-mygj2nd4 896 10 hydralazine hydralazine NNP cord-009571-mygj2nd4 896 11 and/or and/or CC cord-009571-mygj2nd4 896 12 its -PRON- PRP$ cord-009571-mygj2nd4 896 13 metabolites metabolite NNS cord-009571-mygj2nd4 896 14 ( ( -LRB- cord-009571-mygj2nd4 896 15 JCI JCI NNP cord-009571-mygj2nd4 896 16 56:958 56:958 CD cord-009571-mygj2nd4 896 17 , , , cord-009571-mygj2nd4 896 18 1975 1975 CD cord-009571-mygj2nd4 896 19 ) ) -RRB- cord-009571-mygj2nd4 896 20 including include VBG cord-009571-mygj2nd4 896 21 the the DT cord-009571-mygj2nd4 896 22 3 3 CD cord-009571-mygj2nd4 896 23 with with IN cord-009571-mygj2nd4 896 24 positive positive JJ cord-009571-mygj2nd4 896 25 ANF ANF NNP cord-009571-mygj2nd4 896 26 . . . cord-009571-mygj2nd4 897 1 Acetylation acetylation NN cord-009571-mygj2nd4 897 2 rates rate NNS cord-009571-mygj2nd4 897 3 were be VBD cord-009571-mygj2nd4 897 4 obtained obtain VBN cord-009571-mygj2nd4 897 5 in in IN cord-009571-mygj2nd4 897 6 22 22 CD cord-009571-mygj2nd4 897 7 of of IN cord-009571-mygj2nd4 897 8 the the DT cord-009571-mygj2nd4 897 9 hypertensive hypertensive JJ cord-009571-mygj2nd4 897 10 patients patient NNS cord-009571-mygj2nd4 897 11 . . . cord-009571-mygj2nd4 898 1 Thirteen thirteen CD cord-009571-mygj2nd4 898 2 were be VBD cord-009571-mygj2nd4 898 3 slow slow JJ cord-009571-mygj2nd4 898 4 and and CC cord-009571-mygj2nd4 898 5 9 9 CD cord-009571-mygj2nd4 898 6 fast fast JJ cord-009571-mygj2nd4 898 7 acetylators acetylator NNS cord-009571-mygj2nd4 898 8 . . . cord-009571-mygj2nd4 899 1 The the DT cord-009571-mygj2nd4 899 2 3 3 CD cord-009571-mygj2nd4 899 3 A A NNP cord-009571-mygj2nd4 899 4 N N NNP cord-009571-mygj2nd4 899 5 F F NNP cord-009571-mygj2nd4 899 6 positive positive JJ cord-009571-mygj2nd4 899 7 subjects subject NNS cord-009571-mygj2nd4 899 8 were be VBD cord-009571-mygj2nd4 899 9 all all DT cord-009571-mygj2nd4 899 10 slow slow JJ cord-009571-mygj2nd4 899 11 acetylators acetylator NNS cord-009571-mygj2nd4 899 12 as as IN cord-009571-mygj2nd4 899 13 were be VBD cord-009571-mygj2nd4 899 14 4 4 CD cord-009571-mygj2nd4 899 15 of of IN cord-009571-mygj2nd4 899 16 the the DT cord-009571-mygj2nd4 899 17 5 5 CD cord-009571-mygj2nd4 899 18 with with IN cord-009571-mygj2nd4 899 19 proliferative proliferative JJ cord-009571-mygj2nd4 899 20 lymphocyte lymphocyte NN cord-009571-mygj2nd4 899 21 responses response NNS cord-009571-mygj2nd4 899 22 to to IN cord-009571-mygj2nd4 899 23 hydralazine hydralazine NNP cord-009571-mygj2nd4 899 24 and and CC cord-009571-mygj2nd4 899 25 its -PRON- PRP$ cord-009571-mygj2nd4 899 26 metabolites metabolite NNS cord-009571-mygj2nd4 899 27 . . . cord-009571-mygj2nd4 900 1 This this DT cord-009571-mygj2nd4 900 2 study study NN cord-009571-mygj2nd4 900 3 t t NN cord-009571-mygj2nd4 900 4 o o NN cord-009571-mygj2nd4 900 5 date date NN cord-009571-mygj2nd4 900 6 suggests suggest VBZ cord-009571-mygj2nd4 900 7 that that IN cord-009571-mygj2nd4 900 8 hydralazine hydralazine NN cord-009571-mygj2nd4 900 9 in in IN cord-009571-mygj2nd4 900 10 its -PRON- PRP$ cord-009571-mygj2nd4 900 11 present present JJ cord-009571-mygj2nd4 900 12 form form NN cord-009571-mygj2nd4 900 13 may may MD cord-009571-mygj2nd4 900 14 be be VB cord-009571-mygj2nd4 900 15 less less RBR cord-009571-mygj2nd4 900 16 likely likely JJ cord-009571-mygj2nd4 900 17 t t XX cord-009571-mygj2nd4 900 18 o o NN cord-009571-mygj2nd4 900 19 cause cause VB cord-009571-mygj2nd4 900 20 serologic serologic JJ cord-009571-mygj2nd4 900 21 and and CC cord-009571-mygj2nd4 900 22 clinical clinical JJ cord-009571-mygj2nd4 900 23 SLE sle NN cord-009571-mygj2nd4 900 24 than than IN cord-009571-mygj2nd4 900 25 previously previously RB cord-009571-mygj2nd4 900 26 reported report VBN cord-009571-mygj2nd4 900 27 and and CC cord-009571-mygj2nd4 900 28 that that IN cord-009571-mygj2nd4 900 29 screening screening NN cord-009571-mygj2nd4 900 30 by by IN cord-009571-mygj2nd4 900 31 acetylation acetylation NN cord-009571-mygj2nd4 900 32 rates rate NNS cord-009571-mygj2nd4 900 33 may may MD cord-009571-mygj2nd4 900 34 define define VB cord-009571-mygj2nd4 900 35 a a DT cord-009571-mygj2nd4 900 36 susceptible susceptible JJ cord-009571-mygj2nd4 900 37 population population NN cord-009571-mygj2nd4 900 38 . . . cord-009571-mygj2nd4 901 1 This this DT cord-009571-mygj2nd4 901 2 and and CC cord-009571-mygj2nd4 901 3 other other JJ cord-009571-mygj2nd4 901 4 lupus lupus NN cord-009571-mygj2nd4 901 5 related relate VBN cord-009571-mygj2nd4 902 1 drugs drug NNS cord-009571-mygj2nd4 902 2 continue continue VBP cord-009571-mygj2nd4 902 3 t t NN cord-009571-mygj2nd4 902 4 o o UH cord-009571-mygj2nd4 902 5 be be VB cord-009571-mygj2nd4 902 6 a a DT cord-009571-mygj2nd4 902 7 rich rich JJ cord-009571-mygj2nd4 902 8 source source NN cord-009571-mygj2nd4 902 9 of of IN cord-009571-mygj2nd4 902 10 data datum NNS cord-009571-mygj2nd4 902 11 relevant relevant JJ cord-009571-mygj2nd4 902 12 to to IN cord-009571-mygj2nd4 902 13 lupus lupus NN cord-009571-mygj2nd4 902 14 in in IN cord-009571-mygj2nd4 902 15 humans human NNS cord-009571-mygj2nd4 902 16 . . . cord-009571-mygj2nd4 903 1 ( ( -LRB- cord-009571-mygj2nd4 903 2 Supported support VBN cord-009571-mygj2nd4 903 3 by by IN cord-009571-mygj2nd4 903 4 an an DT cord-009571-mygj2nd4 903 5 NIAMDD NIAMDD NNP cord-009571-mygj2nd4 903 6 Grant Grant NNP cord-009571-mygj2nd4 903 7 ) ) -RRB- cord-009571-mygj2nd4 903 8 . . . cord-009571-mygj2nd4 904 1 Normal normal JJ cord-009571-mygj2nd4 904 2 neutrophils neutrophil NNS cord-009571-mygj2nd4 904 3 ( ( -LRB- cord-009571-mygj2nd4 904 4 PMNs PMNs NNP cord-009571-mygj2nd4 904 5 ) ) -RRB- cord-009571-mygj2nd4 904 6 develop develop VB cord-009571-mygj2nd4 904 7 intracytoplasmic intracytoplasmic JJ cord-009571-mygj2nd4 904 8 inclusions inclusion NNS cord-009571-mygj2nd4 904 9 after after IN cord-009571-mygj2nd4 904 10 incubation incubation NN cord-009571-mygj2nd4 904 11 with with IN cord-009571-mygj2nd4 904 12 SLE SLE NNP cord-009571-mygj2nd4 904 13 sera sera NNP cord-009571-mygj2nd4 904 14 . . . cord-009571-mygj2nd4 905 1 The the DT cord-009571-mygj2nd4 905 2 resulting result VBG cord-009571-mygj2nd4 905 3 inclusions inclusion NNS cord-009571-mygj2nd4 905 4 stain stain NN cord-009571-mygj2nd4 905 5 for for IN cord-009571-mygj2nd4 905 6 IgG IgG NNP cord-009571-mygj2nd4 905 7 , , , cord-009571-mygj2nd4 905 8 IgM IgM NNP cord-009571-mygj2nd4 905 9 , , , cord-009571-mygj2nd4 905 10 and and CC cord-009571-mygj2nd4 905 11 C3 C3 NNP cord-009571-mygj2nd4 905 12 and and CC cord-009571-mygj2nd4 905 13 are be VBP cord-009571-mygj2nd4 905 14 believed believe VBN cord-009571-mygj2nd4 905 15 to to TO cord-009571-mygj2nd4 905 16 be be VB cord-009571-mygj2nd4 905 17 immune immune JJ cord-009571-mygj2nd4 905 18 complexes complex NNS cord-009571-mygj2nd4 905 19 removed remove VBN cord-009571-mygj2nd4 905 20 from from IN cord-009571-mygj2nd4 905 21 the the DT cord-009571-mygj2nd4 905 22 sera sera NNP cord-009571-mygj2nd4 905 23 in in IN cord-009571-mygj2nd4 905 24 vitro vitro NNP cord-009571-mygj2nd4 905 25 . . . cord-009571-mygj2nd4 906 1 Such such JJ cord-009571-mygj2nd4 906 2 inclusions inclusion NNS cord-009571-mygj2nd4 906 3 have have VBP cord-009571-mygj2nd4 906 4 also also RB cord-009571-mygj2nd4 906 5 been be VBN cord-009571-mygj2nd4 906 6 identified identify VBN cord-009571-mygj2nd4 906 7 in in IN cord-009571-mygj2nd4 906 8 the the DT cord-009571-mygj2nd4 906 9 circulating circulate VBG cord-009571-mygj2nd4 906 10 PMNs pmn NNS cord-009571-mygj2nd4 906 11 from from IN cord-009571-mygj2nd4 906 12 SLE SLE NNP cord-009571-mygj2nd4 906 13 patients patient NNS cord-009571-mygj2nd4 906 14 . . . cord-009571-mygj2nd4 907 1 The the DT cord-009571-mygj2nd4 907 2 present present JJ cord-009571-mygj2nd4 907 3 study study NN cord-009571-mygj2nd4 907 4 examined examine VBD cord-009571-mygj2nd4 907 5 the the DT cord-009571-mygj2nd4 907 6 relationship relationship NN cord-009571-mygj2nd4 907 7 between between IN cord-009571-mygj2nd4 907 8 PMN PMN NNP cord-009571-mygj2nd4 907 9 inclusions inclusion NNS cord-009571-mygj2nd4 907 10 and and CC cord-009571-mygj2nd4 907 11 clinical clinical JJ cord-009571-mygj2nd4 907 12 and and CC cord-009571-mygj2nd4 907 13 laboratory laboratory NN cord-009571-mygj2nd4 907 14 features feature NNS cord-009571-mygj2nd4 907 15 of of IN cord-009571-mygj2nd4 907 16 SLE SLE NNP cord-009571-mygj2nd4 907 17 . . . cord-009571-mygj2nd4 908 1 Sera Sera NNP cord-009571-mygj2nd4 908 2 were be VBD cord-009571-mygj2nd4 908 3 carefully carefully RB cord-009571-mygj2nd4 908 4 collected collect VBN cord-009571-mygj2nd4 908 5 at at IN cord-009571-mygj2nd4 908 6 37 37 CD cord-009571-mygj2nd4 908 7 " " `` cord-009571-mygj2nd4 908 8 from from IN cord-009571-mygj2nd4 908 9 35 35 CD cord-009571-mygj2nd4 908 10 SLE SLE NNP cord-009571-mygj2nd4 908 11 patients patient NNS cord-009571-mygj2nd4 908 12 . . . cord-009571-mygj2nd4 909 1 Normal normal JJ cord-009571-mygj2nd4 909 2 buffy buffy NNP cord-009571-mygj2nd4 909 3 coat coat NN cord-009571-mygj2nd4 909 4 cells cell NNS cord-009571-mygj2nd4 909 5 were be VBD cord-009571-mygj2nd4 909 6 incubated incubate VBN cord-009571-mygj2nd4 909 7 in in IN cord-009571-mygj2nd4 909 8 the the DT cord-009571-mygj2nd4 909 9 SLE SLE NNP cord-009571-mygj2nd4 909 10 sera sera NNP cord-009571-mygj2nd4 909 11 for for IN cord-009571-mygj2nd4 909 12 90 90 CD cord-009571-mygj2nd4 909 13 minutes minute NNS cord-009571-mygj2nd4 909 14 a a DT cord-009571-mygj2nd4 909 15 t t NN cord-009571-mygj2nd4 909 16 37 37 CD cord-009571-mygj2nd4 909 17 ' ' '' cord-009571-mygj2nd4 909 18 and and CC cord-009571-mygj2nd4 909 19 then then RB cord-009571-mygj2nd4 909 20 centrifuged centrifuge VBD cord-009571-mygj2nd4 909 21 and and CC cord-009571-mygj2nd4 909 22 washed wash VBN cord-009571-mygj2nd4 909 23 . . . cord-009571-mygj2nd4 910 1 Slides slide NNS cord-009571-mygj2nd4 910 2 of of IN cord-009571-mygj2nd4 910 3 the the DT cord-009571-mygj2nd4 910 4 washed wash VBN cord-009571-mygj2nd4 910 5 cells cell NNS cord-009571-mygj2nd4 910 6 were be VBD cord-009571-mygj2nd4 910 7 prepared prepare VBN cord-009571-mygj2nd4 910 8 in in IN cord-009571-mygj2nd4 910 9 the the DT cord-009571-mygj2nd4 910 10 cytocentrifuge cytocentrifuge NN cord-009571-mygj2nd4 910 11 , , , cord-009571-mygj2nd4 910 12 stained stain VBN cord-009571-mygj2nd4 910 13 with with IN cord-009571-mygj2nd4 910 14 FITC FITC NNP cord-009571-mygj2nd4 910 15 goat goat NN cord-009571-mygj2nd4 910 16 anti anti JJ cord-009571-mygj2nd4 910 17 - - JJ cord-009571-mygj2nd4 910 18 human human JJ cord-009571-mygj2nd4 910 19 IgG IgG NNP cord-009571-mygj2nd4 910 20 , , , cord-009571-mygj2nd4 910 21 IgM IgM NNP cord-009571-mygj2nd4 910 22 , , , cord-009571-mygj2nd4 910 23 IgA IgA NNP cord-009571-mygj2nd4 910 24 , , , cord-009571-mygj2nd4 910 25 and and CC cord-009571-mygj2nd4 910 26 C3 C3 NNP cord-009571-mygj2nd4 910 27 , , , cord-009571-mygj2nd4 910 28 and and CC cord-009571-mygj2nd4 910 29 examined examine VBD cord-009571-mygj2nd4 910 30 under under IN cord-009571-mygj2nd4 910 31 ultraviolet ultraviolet JJ cord-009571-mygj2nd4 910 32 light light NN cord-009571-mygj2nd4 910 33 . . . cord-009571-mygj2nd4 911 1 The the DT cord-009571-mygj2nd4 911 2 composition composition NN cord-009571-mygj2nd4 911 3 of of IN cord-009571-mygj2nd4 911 4 these these DT cord-009571-mygj2nd4 911 5 complexes complex NNS cord-009571-mygj2nd4 911 6 was be VBD cord-009571-mygj2nd4 911 7 also also RB cord-009571-mygj2nd4 911 8 examined examine VBN cord-009571-mygj2nd4 911 9 with with IN cord-009571-mygj2nd4 911 10 a a DT cord-009571-mygj2nd4 911 11 fluorescent fluorescent JJ cord-009571-mygj2nd4 911 12 probe probe NN cord-009571-mygj2nd4 911 13 for for IN cord-009571-mygj2nd4 911 14 double double RB cord-009571-mygj2nd4 911 15 - - HYPH cord-009571-mygj2nd4 911 16 stranded strand VBN cord-009571-mygj2nd4 911 17 polynucleotides polynucleotide NNS cord-009571-mygj2nd4 911 18 with with IN cord-009571-mygj2nd4 911 19 the the DT cord-009571-mygj2nd4 911 20 aid aid NN cord-009571-mygj2nd4 911 21 of of IN cord-009571-mygj2nd4 911 22 ethidium ethidium NN cord-009571-mygj2nd4 911 23 bromide bromide NN cord-009571-mygj2nd4 911 24 ( ( -LRB- cord-009571-mygj2nd4 911 25 EB EB NNP cord-009571-mygj2nd4 911 26 ) ) -RRB- cord-009571-mygj2nd4 911 27 . . . cord-009571-mygj2nd4 912 1 EB EB NNP cord-009571-mygj2nd4 912 2 was be VBD cord-009571-mygj2nd4 912 3 added add VBN cord-009571-mygj2nd4 912 4 t t NNP cord-009571-mygj2nd4 912 5 o o NNP cord-009571-mygj2nd4 912 6 sera sera NNP cord-009571-mygj2nd4 912 7 known know VBN cord-009571-mygj2nd4 912 8 to to TO cord-009571-mygj2nd4 912 9 contain contain VB cord-009571-mygj2nd4 912 10 high high JJ cord-009571-mygj2nd4 912 11 concentrations concentration NNS cord-009571-mygj2nd4 912 12 of of IN cord-009571-mygj2nd4 912 13 anti anti JJ cord-009571-mygj2nd4 912 14 - - JJ cord-009571-mygj2nd4 912 15 DNA dna JJ cord-009571-mygj2nd4 912 16 antibodies antibody NNS cord-009571-mygj2nd4 912 17 and and CC cord-009571-mygj2nd4 912 18 then then RB cord-009571-mygj2nd4 912 19 incubated incubate VBN cord-009571-mygj2nd4 912 20 with with IN cord-009571-mygj2nd4 912 21 normal normal JJ cord-009571-mygj2nd4 912 22 PMNs pmn NNS cord-009571-mygj2nd4 912 23 as as IN cord-009571-mygj2nd4 912 24 before before RB cord-009571-mygj2nd4 912 25 . . . cord-009571-mygj2nd4 913 1 Preparations preparation NNS cord-009571-mygj2nd4 913 2 included include VBD cord-009571-mygj2nd4 913 3 1 1 CD cord-009571-mygj2nd4 913 4 ) ) -RRB- cord-009571-mygj2nd4 913 5 no no DT cord-009571-mygj2nd4 913 6 added add VBN cord-009571-mygj2nd4 913 7 EB EB NNP cord-009571-mygj2nd4 913 8 , , , cord-009571-mygj2nd4 913 9 2 2 CD cord-009571-mygj2nd4 913 10 ) ) -RRB- cord-009571-mygj2nd4 913 11 EB EB NNP cord-009571-mygj2nd4 913 12 only only RB cord-009571-mygj2nd4 913 13 , , , cord-009571-mygj2nd4 913 14 3 3 CD cord-009571-mygj2nd4 913 15 ) ) -RRB- cord-009571-mygj2nd4 913 16 FITC FITC NNP cord-009571-mygj2nd4 913 17 anti anti JJ cord-009571-mygj2nd4 913 18 - - JJ cord-009571-mygj2nd4 913 19 human human JJ cord-009571-mygj2nd4 913 20 IgG igg NN cord-009571-mygj2nd4 913 21 ( ( -LRB- cord-009571-mygj2nd4 913 22 FIanti FIanti NNP cord-009571-mygj2nd4 913 23 - - HYPH cord-009571-mygj2nd4 913 24 IgG IgG NNP cord-009571-mygj2nd4 913 25 ) ) -RRB- cord-009571-mygj2nd4 913 26 or or CC cord-009571-mygj2nd4 913 27 4 4 CD cord-009571-mygj2nd4 913 28 ) ) -RRB- cord-009571-mygj2nd4 913 29 F1-anti f1-anti NN cord-009571-mygj2nd4 913 30 - - HYPH cord-009571-mygj2nd4 913 31 IgG igg NN cord-009571-mygj2nd4 913 32 and and CC cord-009571-mygj2nd4 913 33 EB EB NNP cord-009571-mygj2nd4 913 34 . . . cord-009571-mygj2nd4 914 1 Inclusions inclusion NNS cord-009571-mygj2nd4 914 2 containing contain VBG cord-009571-mygj2nd4 914 3 both both CC cord-009571-mygj2nd4 914 4 IgG IgG NNP cord-009571-mygj2nd4 914 5 and and CC cord-009571-mygj2nd4 914 6 IgM IgM NNP cord-009571-mygj2nd4 914 7 correlated correlate VBD cord-009571-mygj2nd4 914 8 with with IN cord-009571-mygj2nd4 914 9 clinical clinical JJ cord-009571-mygj2nd4 914 10 activity activity NN cord-009571-mygj2nd4 914 11 ( ( -LRB- cord-009571-mygj2nd4 914 12 P p NN cord-009571-mygj2nd4 914 13 < < XX cord-009571-mygj2nd4 914 14 0.001 0.001 CD cord-009571-mygj2nd4 914 15 ) ) -RRB- cord-009571-mygj2nd4 914 16 , , , cord-009571-mygj2nd4 914 17 depressed depressed JJ cord-009571-mygj2nd4 914 18 serum serum NN cord-009571-mygj2nd4 914 19 complement complement NN cord-009571-mygj2nd4 914 20 ( ( -LRB- cord-009571-mygj2nd4 914 21 P p NN cord-009571-mygj2nd4 914 22 = = SYM cord-009571-mygj2nd4 914 23 0.026 0.026 CD cord-009571-mygj2nd4 914 24 ) ) -RRB- cord-009571-mygj2nd4 914 25 , , , cord-009571-mygj2nd4 914 26 cryoglobulinemia cryoglobulinemia NNP cord-009571-mygj2nd4 914 27 ( ( -LRB- cord-009571-mygj2nd4 914 28 P p NN cord-009571-mygj2nd4 914 29 = = SYM cord-009571-mygj2nd4 914 30 0.014 0.014 CD cord-009571-mygj2nd4 914 31 ) ) -RRB- cord-009571-mygj2nd4 914 32 , , , cord-009571-mygj2nd4 914 33 and and CC cord-009571-mygj2nd4 914 34 anti anti JJ cord-009571-mygj2nd4 914 35 - - JJ cord-009571-mygj2nd4 914 36 nDNA ndna JJ cord-009571-mygj2nd4 914 37 antibodies antibody NNS cord-009571-mygj2nd4 914 38 ( ( -LRB- cord-009571-mygj2nd4 914 39 P p NN cord-009571-mygj2nd4 914 40 < < XX cord-009571-mygj2nd4 914 41 0.001 0.001 CD cord-009571-mygj2nd4 914 42 ) ) -RRB- cord-009571-mygj2nd4 914 43 . . . cord-009571-mygj2nd4 915 1 IgG IgG NNP cord-009571-mygj2nd4 915 2 inclusions inclusion NNS cord-009571-mygj2nd4 915 3 alone alone RB cord-009571-mygj2nd4 915 4 were be VBD cord-009571-mygj2nd4 915 5 not not RB cord-009571-mygj2nd4 915 6 significantly significantly RB cord-009571-mygj2nd4 915 7 correlated correlate VBN cord-009571-mygj2nd4 915 8 with with IN cord-009571-mygj2nd4 915 9 any any DT cord-009571-mygj2nd4 915 10 of of IN cord-009571-mygj2nd4 915 11 the the DT cord-009571-mygj2nd4 915 12 parameters parameter NNS cord-009571-mygj2nd4 915 13 . . . cord-009571-mygj2nd4 916 1 C3 C3 NNP cord-009571-mygj2nd4 916 2 and and CC cord-009571-mygj2nd4 916 3 IgM IgM NNP cord-009571-mygj2nd4 916 4 appeared appear VBD cord-009571-mygj2nd4 916 5 to to TO cord-009571-mygj2nd4 916 6 be be VB cord-009571-mygj2nd4 916 7 mutually mutually RB cord-009571-mygj2nd4 916 8 exclusive exclusive JJ cord-009571-mygj2nd4 916 9 , , , cord-009571-mygj2nd4 916 10 i.e. i.e. FW cord-009571-mygj2nd4 916 11 when when WRB cord-009571-mygj2nd4 916 12 one one PRP cord-009571-mygj2nd4 916 13 was be VBD cord-009571-mygj2nd4 916 14 present present JJ cord-009571-mygj2nd4 916 15 , , , cord-009571-mygj2nd4 916 16 the the DT cord-009571-mygj2nd4 916 17 other other JJ cord-009571-mygj2nd4 916 18 was be VBD cord-009571-mygj2nd4 916 19 never never RB cord-009571-mygj2nd4 916 20 present present JJ cord-009571-mygj2nd4 916 21 . . . cord-009571-mygj2nd4 917 1 EB EB NNP cord-009571-mygj2nd4 917 2 staining staining NN cord-009571-mygj2nd4 917 3 inclusions inclusion NNS cord-009571-mygj2nd4 917 4 ( ( -LRB- cord-009571-mygj2nd4 917 5 red red JJ cord-009571-mygj2nd4 917 6 fluorescence fluorescence NN cord-009571-mygj2nd4 917 7 ) ) -RRB- cord-009571-mygj2nd4 917 8 suggested suggest VBD cord-009571-mygj2nd4 917 9 that that IN cord-009571-mygj2nd4 917 10 polynucleotides polynucleotides NNP cord-009571-mygj2nd4 917 11 were be VBD cord-009571-mygj2nd4 917 12 present present JJ cord-009571-mygj2nd4 917 13 . . . cord-009571-mygj2nd4 918 1 These these DT cord-009571-mygj2nd4 918 2 findings finding NNS cord-009571-mygj2nd4 918 3 suggest suggest VBP cord-009571-mygj2nd4 918 4 : : : cord-009571-mygj2nd4 918 5 1 1 LS cord-009571-mygj2nd4 918 6 ) ) -RRB- cord-009571-mygj2nd4 918 7 the the DT cord-009571-mygj2nd4 918 8 PMN PMN NNP cord-009571-mygj2nd4 918 9 inclusions inclusion NNS cord-009571-mygj2nd4 918 10 consist consist VBP cord-009571-mygj2nd4 918 11 of of IN cord-009571-mygj2nd4 918 12 immune immune JJ cord-009571-mygj2nd4 918 13 complexes complex NNS cord-009571-mygj2nd4 918 14 which which WDT cord-009571-mygj2nd4 918 15 contain contain VBP cord-009571-mygj2nd4 918 16 double double RB cord-009571-mygj2nd4 918 17 - - HYPH cord-009571-mygj2nd4 918 18 stranded strand VBN cord-009571-mygj2nd4 918 19 polynucleotides polynucleotide NNS cord-009571-mygj2nd4 918 20 , , , cord-009571-mygj2nd4 918 21 2 2 LS cord-009571-mygj2nd4 918 22 ) ) -RRB- cord-009571-mygj2nd4 918 23 these these DT cord-009571-mygj2nd4 918 24 complexes complex NNS cord-009571-mygj2nd4 918 25 correlate correlate VBP cord-009571-mygj2nd4 918 26 with with IN cord-009571-mygj2nd4 918 27 disease disease NN cord-009571-mygj2nd4 918 28 activity activity NN cord-009571-mygj2nd4 918 29 when when WRB cord-009571-mygj2nd4 918 30 IgG IgG NNP cord-009571-mygj2nd4 918 31 and and CC cord-009571-mygj2nd4 918 32 IgM IgM NNP cord-009571-mygj2nd4 918 33 are be VBP cord-009571-mygj2nd4 918 34 both both DT cord-009571-mygj2nd4 918 35 present present JJ cord-009571-mygj2nd4 918 36 , , , cord-009571-mygj2nd4 918 37 and and CC cord-009571-mygj2nd4 918 38 3 3 LS cord-009571-mygj2nd4 918 39 ) ) -RRB- cord-009571-mygj2nd4 918 40 such such JJ cord-009571-mygj2nd4 918 41 complexes complex NNS cord-009571-mygj2nd4 918 42 may may MD cord-009571-mygj2nd4 918 43 contribute contribute VB cord-009571-mygj2nd4 918 44 to to IN cord-009571-mygj2nd4 918 45 a a DT cord-009571-mygj2nd4 918 46 number number NN cord-009571-mygj2nd4 918 47 of of IN cord-009571-mygj2nd4 918 48 granulocyte granulocyte NN cord-009571-mygj2nd4 918 49 disturbances disturbance NNS cord-009571-mygj2nd4 918 50 seen see VBN cord-009571-mygj2nd4 918 51 in in IN cord-009571-mygj2nd4 918 52 patients patient NNS cord-009571-mygj2nd4 918 53 with with IN cord-009571-mygj2nd4 918 54 SLE SLE NNP cord-009571-mygj2nd4 918 55 . . . cord-009571-mygj2nd4 919 1 In in IN cord-009571-mygj2nd4 919 2 previous previous JJ cord-009571-mygj2nd4 919 3 studies study NNS cord-009571-mygj2nd4 919 4 on on IN cord-009571-mygj2nd4 919 5 preservation preservation NN cord-009571-mygj2nd4 919 6 of of IN cord-009571-mygj2nd4 919 7 articular articular JJ cord-009571-mygj2nd4 919 8 carti-(324,000 carti-(324,000 NNP cord-009571-mygj2nd4 919 9 dpm dpm NNP cord-009571-mygj2nd4 919 10 / / SYM cord-009571-mygj2nd4 919 11 mg mg NNP cord-009571-mygj2nd4 919 12 protein protein NN cord-009571-mygj2nd4 919 13 ) ) -RRB- cord-009571-mygj2nd4 919 14 permitted permit VBD cord-009571-mygj2nd4 919 15 quantitation quantitation NN cord-009571-mygj2nd4 919 16 of of IN cord-009571-mygj2nd4 919 17 the the DT cord-009571-mygj2nd4 919 18 neulage neulage NN cord-009571-mygj2nd4 919 19 performed perform VBN cord-009571-mygj2nd4 919 20 in in IN cord-009571-mygj2nd4 919 21 our -PRON- PRP$ cord-009571-mygj2nd4 919 22 laboratories laboratory NNS cord-009571-mygj2nd4 919 23 , , , cord-009571-mygj2nd4 919 24 it -PRON- PRP cord-009571-mygj2nd4 919 25 was be VBD cord-009571-mygj2nd4 919 26 found find VBN cord-009571-mygj2nd4 919 27 that that IN cord-009571-mygj2nd4 919 28 addition addition NN cord-009571-mygj2nd4 919 29 tral tral JJ cord-009571-mygj2nd4 919 30 protease protease NN cord-009571-mygj2nd4 919 31 activity activity NN cord-009571-mygj2nd4 919 32 released release VBN cord-009571-mygj2nd4 919 33 into into IN cord-009571-mygj2nd4 919 34 the the DT cord-009571-mygj2nd4 919 35 media medium NNS cord-009571-mygj2nd4 919 36 of of IN cord-009571-mygj2nd4 919 37 the the DT cord-009571-mygj2nd4 919 38 stored store VBN cord-009571-mygj2nd4 919 39 of of IN cord-009571-mygj2nd4 919 40 a a DT cord-009571-mygj2nd4 919 41 - - HYPH cord-009571-mygj2nd4 919 42 tocopherol tocopherol NN cord-009571-mygj2nd4 919 43 ( ( -LRB- cord-009571-mygj2nd4 919 44 200 200 CD cord-009571-mygj2nd4 919 45 pg pg NN cord-009571-mygj2nd4 919 46 / / SYM cord-009571-mygj2nd4 919 47 ml ml NN cord-009571-mygj2nd4 919 48 ) ) -RRB- cord-009571-mygj2nd4 919 49 to to IN cord-009571-mygj2nd4 919 50 the the DT cord-009571-mygj2nd4 919 51 culture culture NN cord-009571-mygj2nd4 919 52 media medium NNS cord-009571-mygj2nd4 919 53 of of IN cord-009571-mygj2nd4 919 54 stored store VBN cord-009571-mygj2nd4 919 55 cartilage cartilage NN cord-009571-mygj2nd4 919 56 explants explant NNS cord-009571-mygj2nd4 919 57 . . . cord-009571-mygj2nd4 920 1 Employing employ VBG cord-009571-mygj2nd4 920 2 this this DT cord-009571-mygj2nd4 920 3 assay assay NN cord-009571-mygj2nd4 920 4 we -PRON- PRP cord-009571-mygj2nd4 920 5 found find VBD cord-009571-mygj2nd4 920 6 that that IN cord-009571-mygj2nd4 920 7 acartilage acartilage NN cord-009571-mygj2nd4 920 8 resulted result VBD cord-009571-mygj2nd4 920 9 in in IN cord-009571-mygj2nd4 920 10 improved improved JJ cord-009571-mygj2nd4 920 11 preservation preservation NN cord-009571-mygj2nd4 920 12 of of IN cord-009571-mygj2nd4 920 13 its -PRON- PRP$ cord-009571-mygj2nd4 920 14 biochemical biochemical JJ cord-009571-mygj2nd4 920 15 tocopherol tocopherol NN cord-009571-mygj2nd4 920 16 resulted result VBD cord-009571-mygj2nd4 920 17 in in IN cord-009571-mygj2nd4 920 18 significant significant JJ cord-009571-mygj2nd4 920 19 inhibition inhibition NN cord-009571-mygj2nd4 920 20 of of IN cord-009571-mygj2nd4 920 21 this this DT cord-009571-mygj2nd4 920 22 activity activity NN cord-009571-mygj2nd4 920 23 as as IN cord-009571-mygj2nd4 920 24 and and CC cord-009571-mygj2nd4 920 25 biomechanical biomechanical JJ cord-009571-mygj2nd4 920 26 properties property NNS cord-009571-mygj2nd4 920 27 when when WRB cord-009571-mygj2nd4 920 28 compared compare VBN cord-009571-mygj2nd4 920 29 to to IN cord-009571-mygj2nd4 920 30 cartilage cartilage NN cord-009571-mygj2nd4 920 31 shown show VBN cord-009571-mygj2nd4 920 32 in in IN cord-009571-mygj2nd4 920 33 the the DT cord-009571-mygj2nd4 920 34 table table NN cord-009571-mygj2nd4 920 35 . . . cord-009571-mygj2nd4 921 1 stored store VBN cord-009571-mygj2nd4 921 2 in in IN cord-009571-mygj2nd4 921 3 absence absence NN cord-009571-mygj2nd4 921 4 of of IN cord-009571-mygj2nd4 921 5 the the DT cord-009571-mygj2nd4 921 6 vitamin vitamin NN cord-009571-mygj2nd4 921 7 . . . cord-009571-mygj2nd4 922 1 Although although IN cord-009571-mygj2nd4 922 2 it -PRON- PRP cord-009571-mygj2nd4 922 3 has have VBZ cord-009571-mygj2nd4 922 4 been be VBN cord-009571-mygj2nd4 922 5 shown show VBN cord-009571-mygj2nd4 922 6 that that IN cord-009571-mygj2nd4 922 7 a a DT cord-009571-mygj2nd4 922 8 - - HYPH cord-009571-mygj2nd4 922 9 tocopherol tocopherol NN cord-009571-mygj2nd4 922 10 stabilizes stabilize VBZ cord-009571-mygj2nd4 922 11 lysosomal lysosomal JJ cord-009571-mygj2nd4 922 12 membranes membrane NNS cord-009571-mygj2nd4 922 13 in in IN cord-009571-mygj2nd4 922 14 other other JJ cord-009571-mygj2nd4 922 15 lage lage NNP cord-009571-mygj2nd4 922 16 were be VBD cord-009571-mygj2nd4 922 17 due due JJ cord-009571-mygj2nd4 922 18 to to IN cord-009571-mygj2nd4 922 19 stabilization stabilization NN cord-009571-mygj2nd4 922 20 of of IN cord-009571-mygj2nd4 922 21 lysosomal lysosomal JJ cord-009571-mygj2nd4 922 22 membranes membrane NNS cord-009571-mygj2nd4 922 23 , , , cord-009571-mygj2nd4 922 24 we -PRON- PRP cord-009571-mygj2nd4 923 1 No no UH cord-009571-mygj2nd4 923 2 . . . cord-009571-mygj2nd4 924 1 Control control NN cord-009571-mygj2nd4 924 2 + + CC cord-009571-mygj2nd4 924 3 a a DT cord-009571-mygj2nd4 924 4 - - HYPH cord-009571-mygj2nd4 924 5 tocopherol tocopherol NN cord-009571-mygj2nd4 924 6 Control Control NNP cord-009571-mygj2nd4 924 7 + + CC cord-009571-mygj2nd4 924 8 a a DT cord-009571-mygj2nd4 924 9 - - HYPH cord-009571-mygj2nd4 924 10 tocopherol tocopherol NN cord-009571-mygj2nd4 924 11 developed develop VBD cord-009571-mygj2nd4 924 12 a a DT cord-009571-mygj2nd4 924 13 highly highly RB cord-009571-mygj2nd4 924 14 sensitive sensitive JJ cord-009571-mygj2nd4 924 15 assay assay NN cord-009571-mygj2nd4 924 16 for for IN cord-009571-mygj2nd4 924 17 neutral neutral JJ cord-009571-mygj2nd4 924 18 protease protease NN cord-009571-mygj2nd4 924 19 activity activity NN cord-009571-mygj2nd4 924 20 employing employ VBG cord-009571-mygj2nd4 924 21 a a DT cord-009571-mygj2nd4 924 22 biosynthetically biosynthetically RB cord-009571-mygj2nd4 924 23 prepared prepare VBN cord-009571-mygj2nd4 924 24 protein protein NN cord-009571-mygj2nd4 924 25 substrate substrate NN cord-009571-mygj2nd4 924 26 . . . cord-009571-mygj2nd4 925 1 This this DT cord-009571-mygj2nd4 925 2 _SP cord-009571-mygj2nd4 925 3 Five five CD cord-009571-mygj2nd4 925 4 further further JJ cord-009571-mygj2nd4 925 5 patients patient NNS cord-009571-mygj2nd4 925 6 with with IN cord-009571-mygj2nd4 925 7 SLE SLE NNP cord-009571-mygj2nd4 925 8 have have VBP cord-009571-mygj2nd4 925 9 been be VBN cord-009571-mygj2nd4 925 10 treated treat VBN cord-009571-mygj2nd4 925 11 with with IN cord-009571-mygj2nd4 925 12 plasmapheresis plasmapheresis NN cord-009571-mygj2nd4 925 13 . . . cord-009571-mygj2nd4 926 1 Six six CD cord-009571-mygj2nd4 926 2 to to TO cord-009571-mygj2nd4 926 3 8 8 CD cord-009571-mygj2nd4 926 4 liters liter NNS cord-009571-mygj2nd4 926 5 of of IN cord-009571-mygj2nd4 926 6 plasma plasma NN cord-009571-mygj2nd4 926 7 per per IN cord-009571-mygj2nd4 926 8 week week NN cord-009571-mygj2nd4 926 9 were be VBD cord-009571-mygj2nd4 926 10 removed remove VBN cord-009571-mygj2nd4 926 11 , , , cord-009571-mygj2nd4 926 12 using use VBG cord-009571-mygj2nd4 926 13 a a DT cord-009571-mygj2nd4 926 14 Haemonetics Haemonetics NNP cord-009571-mygj2nd4 926 15 Model Model NNP cord-009571-mygj2nd4 926 16 30 30 CD cord-009571-mygj2nd4 926 17 Hood Hood NNP cord-009571-mygj2nd4 926 18 Cell Cell NNP cord-009571-mygj2nd4 926 19 Separator Separator NNP cord-009571-mygj2nd4 926 20 . . . cord-009571-mygj2nd4 927 1 From from IN cord-009571-mygj2nd4 927 2 12 12 CD cord-009571-mygj2nd4 927 3 to to TO cord-009571-mygj2nd4 927 4 32 32 CD cord-009571-mygj2nd4 927 5 liters liter NNS cord-009571-mygj2nd4 927 6 were be VBD cord-009571-mygj2nd4 927 7 removed remove VBN cord-009571-mygj2nd4 927 8 in in IN cord-009571-mygj2nd4 927 9 all all DT cord-009571-mygj2nd4 927 10 . . . cord-009571-mygj2nd4 928 1 Levels level NNS cord-009571-mygj2nd4 928 2 of of IN cord-009571-mygj2nd4 928 3 complement complement NN cord-009571-mygj2nd4 928 4 components component NNS cord-009571-mygj2nd4 928 5 were be VBD cord-009571-mygj2nd4 928 6 measured measure VBN cord-009571-mygj2nd4 928 7 by by IN cord-009571-mygj2nd4 928 8 immunodiffusion immunodiffusion NN cord-009571-mygj2nd4 928 9 and and CC cord-009571-mygj2nd4 928 10 by by IN cord-009571-mygj2nd4 928 11 a a DT cord-009571-mygj2nd4 928 12 hemolytic hemolytic JJ cord-009571-mygj2nd4 928 13 assay assay NN cord-009571-mygj2nd4 928 14 . . . cord-009571-mygj2nd4 929 1 DNA DNA NNP cord-009571-mygj2nd4 929 2 antibodies antibody NNS cord-009571-mygj2nd4 929 3 were be VBD cord-009571-mygj2nd4 929 4 measured measure VBN cord-009571-mygj2nd4 929 5 by by IN cord-009571-mygj2nd4 929 6 passive passive JJ cord-009571-mygj2nd4 929 7 hemagglutination hemagglutination NN cord-009571-mygj2nd4 929 8 of of IN cord-009571-mygj2nd4 929 9 DNA DNA NNP cord-009571-mygj2nd4 929 10 coated coat VBN cord-009571-mygj2nd4 929 11 red red JJ cord-009571-mygj2nd4 929 12 - - HYPH cord-009571-mygj2nd4 929 13 cells cell NNS cord-009571-mygj2nd4 929 14 . . . cord-009571-mygj2nd4 930 1 Immune immune JJ cord-009571-mygj2nd4 930 2 complexes complex NNS cord-009571-mygj2nd4 930 3 were be VBD cord-009571-mygj2nd4 930 4 measured measure VBN cord-009571-mygj2nd4 930 5 in in IN cord-009571-mygj2nd4 930 6 vitro vitro FW cord-009571-mygj2nd4 930 7 by by IN cord-009571-mygj2nd4 930 8 the the DT cord-009571-mygj2nd4 930 9 Raji Raji NNP cord-009571-mygj2nd4 930 10 - - HYPH cord-009571-mygj2nd4 930 11 cell cell NN cord-009571-mygj2nd4 930 12 assay assay NN cord-009571-mygj2nd4 930 13 . . . cord-009571-mygj2nd4 931 1 Two two CD cord-009571-mygj2nd4 931 2 patients patient NNS cord-009571-mygj2nd4 931 3 were be VBD cord-009571-mygj2nd4 931 4 critically critically RB cord-009571-mygj2nd4 931 5 ill ill JJ cord-009571-mygj2nd4 931 6 . . . cord-009571-mygj2nd4 932 1 One one PRP cord-009571-mygj2nd4 932 2 had have VBD cord-009571-mygj2nd4 932 3 seizures seizure NNS cord-009571-mygj2nd4 932 4 , , , cord-009571-mygj2nd4 932 5 pericarditis pericarditis NN cord-009571-mygj2nd4 932 6 , , , cord-009571-mygj2nd4 932 7 pleurisy pleurisy NN cord-009571-mygj2nd4 932 8 , , , cord-009571-mygj2nd4 932 9 and and CC cord-009571-mygj2nd4 932 10 severe severe JJ cord-009571-mygj2nd4 932 11 edema edema NN cord-009571-mygj2nd4 932 12 , , , cord-009571-mygj2nd4 932 13 despite despite IN cord-009571-mygj2nd4 932 14 treatment treatment NN cord-009571-mygj2nd4 932 15 with with IN cord-009571-mygj2nd4 932 16 100 100 CD cord-009571-mygj2nd4 932 17 mg mg NNP cord-009571-mygj2nd4 932 18 prednisone prednisone NNP cord-009571-mygj2nd4 932 19 daily daily RB cord-009571-mygj2nd4 932 20 for for IN cord-009571-mygj2nd4 932 21 one one CD cord-009571-mygj2nd4 932 22 month month NN cord-009571-mygj2nd4 932 23 . . . cord-009571-mygj2nd4 933 1 The the DT cord-009571-mygj2nd4 933 2 Raji Raji NNP cord-009571-mygj2nd4 933 3 assay assay NN cord-009571-mygj2nd4 933 4 was be VBD cord-009571-mygj2nd4 933 5 750 750 CD cord-009571-mygj2nd4 933 6 pg pg NN cord-009571-mygj2nd4 933 7 / / SYM cord-009571-mygj2nd4 933 8 ml ml IN cord-009571-mygj2nd4 933 9 ( ( -LRB- cord-009571-mygj2nd4 933 10 normal normal JJ cord-009571-mygj2nd4 933 11 < < XX cord-009571-mygj2nd4 933 12 40 40 CD cord-009571-mygj2nd4 933 13 pg pg NN cord-009571-mygj2nd4 933 14 / / SYM cord-009571-mygj2nd4 933 15 ml ml NN cord-009571-mygj2nd4 933 16 ) ) -RRB- cord-009571-mygj2nd4 933 17 . . . cord-009571-mygj2nd4 934 1 Following follow VBG cord-009571-mygj2nd4 934 2 the the DT cord-009571-mygj2nd4 934 3 removal removal NN cord-009571-mygj2nd4 934 4 of of IN cord-009571-mygj2nd4 934 5 14 14 CD cord-009571-mygj2nd4 934 6 liters liter NNS cord-009571-mygj2nd4 934 7 of of IN cord-009571-mygj2nd4 934 8 plasma plasma NN cord-009571-mygj2nd4 934 9 her -PRON- PRP$ cord-009571-mygj2nd4 934 10 condition condition NN cord-009571-mygj2nd4 934 11 improved improve VBN cord-009571-mygj2nd4 934 12 dramatically dramatically RB cord-009571-mygj2nd4 934 13 , , , cord-009571-mygj2nd4 934 14 complement complement JJ cord-009571-mygj2nd4 934 15 levels level NNS cord-009571-mygj2nd4 934 16 rose rise VBD cord-009571-mygj2nd4 934 17 to to IN cord-009571-mygj2nd4 934 18 normal normal JJ cord-009571-mygj2nd4 934 19 , , , cord-009571-mygj2nd4 934 20 and and CC cord-009571-mygj2nd4 934 21 Raji Raji NNP cord-009571-mygj2nd4 934 22 assay assay NN cord-009571-mygj2nd4 934 23 fell fall VBD cord-009571-mygj2nd4 934 24 to to IN cord-009571-mygj2nd4 934 25 150 150 CD cord-009571-mygj2nd4 934 26 - - SYM cord-009571-mygj2nd4 934 27 200 200 CD cord-009571-mygj2nd4 934 28 pg pg NN cord-009571-mygj2nd4 934 29 / / SYM cord-009571-mygj2nd4 934 30 ml ml NN cord-009571-mygj2nd4 934 31 . . . cord-009571-mygj2nd4 935 1 The the DT cord-009571-mygj2nd4 935 2 second second JJ cord-009571-mygj2nd4 935 3 acutely acutely RB cord-009571-mygj2nd4 935 4 ill ill JJ cord-009571-mygj2nd4 935 5 patient patient NN cord-009571-mygj2nd4 935 6 had have VBD cord-009571-mygj2nd4 935 7 lupus lupus NN cord-009571-mygj2nd4 935 8 cerebritis cerebritis NNP cord-009571-mygj2nd4 935 9 , , , cord-009571-mygj2nd4 935 10 with with IN cord-009571-mygj2nd4 935 11 a a DT cord-009571-mygj2nd4 935 12 level level NN cord-009571-mygj2nd4 935 13 of of IN cord-009571-mygj2nd4 935 14 only only RB cord-009571-mygj2nd4 935 15 60 60 CD cord-009571-mygj2nd4 935 16 pg pg NN cord-009571-mygj2nd4 935 17 / / SYM cord-009571-mygj2nd4 935 18 ml ml NN cord-009571-mygj2nd4 935 19 on on IN cord-009571-mygj2nd4 935 20 Raji Raji NNP cord-009571-mygj2nd4 935 21 assay assay NN cord-009571-mygj2nd4 935 22 . . . cord-009571-mygj2nd4 936 1 After after IN cord-009571-mygj2nd4 936 2 the the DT cord-009571-mygj2nd4 936 3 removal removal NN cord-009571-mygj2nd4 936 4 of of IN cord-009571-mygj2nd4 936 5 18.6 18.6 CD cord-009571-mygj2nd4 936 6 liters liter NNS cord-009571-mygj2nd4 936 7 of of IN cord-009571-mygj2nd4 936 8 plasma plasma NN cord-009571-mygj2nd4 936 9 there there EX cord-009571-mygj2nd4 936 10 was be VBD cord-009571-mygj2nd4 936 11 no no DT cord-009571-mygj2nd4 936 12 significant significant JJ cord-009571-mygj2nd4 936 13 improvement improvement NN cord-009571-mygj2nd4 936 14 in in IN cord-009571-mygj2nd4 936 15 her -PRON- PRP$ cord-009571-mygj2nd4 936 16 clinical clinical JJ cord-009571-mygj2nd4 936 17 condition condition NN cord-009571-mygj2nd4 936 18 . . . cord-009571-mygj2nd4 937 1 The the DT cord-009571-mygj2nd4 937 2 remaining remain VBG cord-009571-mygj2nd4 937 3 three three CD cord-009571-mygj2nd4 937 4 cases case NNS cord-009571-mygj2nd4 937 5 were be VBD cord-009571-mygj2nd4 937 6 less less RBR cord-009571-mygj2nd4 937 7 severely severely RB cord-009571-mygj2nd4 937 8 ill ill JJ cord-009571-mygj2nd4 937 9 and and CC cord-009571-mygj2nd4 937 10 had have VBD cord-009571-mygj2nd4 937 11 Raji Raji NNP cord-009571-mygj2nd4 937 12 assays assay NNS cord-009571-mygj2nd4 937 13 of of IN cord-009571-mygj2nd4 937 14 350 350 CD cord-009571-mygj2nd4 937 15 , , , cord-009571-mygj2nd4 937 16 257 257 CD cord-009571-mygj2nd4 937 17 , , , cord-009571-mygj2nd4 937 18 and and CC cord-009571-mygj2nd4 937 19 94 94 CD cord-009571-mygj2nd4 937 20 pg pg NN cord-009571-mygj2nd4 937 21 / / SYM cord-009571-mygj2nd4 937 22 ml ml NN cord-009571-mygj2nd4 937 23 . . . cord-009571-mygj2nd4 938 1 They -PRON- PRP cord-009571-mygj2nd4 938 2 showed show VBD cord-009571-mygj2nd4 938 3 a a DT cord-009571-mygj2nd4 938 4 reduction reduction NN cord-009571-mygj2nd4 938 5 of of IN cord-009571-mygj2nd4 938 6 circulating circulate VBG cord-009571-mygj2nd4 938 7 immune immune JJ cord-009571-mygj2nd4 938 8 complexes complex NNS cord-009571-mygj2nd4 938 9 after after IN cord-009571-mygj2nd4 938 10 each each DT cord-009571-mygj2nd4 938 11 plasmapheresis plasmapheresis NN cord-009571-mygj2nd4 938 12 , , , cord-009571-mygj2nd4 938 13 and and CC cord-009571-mygj2nd4 938 14 an an DT cord-009571-mygj2nd4 938 15 overall overall JJ cord-009571-mygj2nd4 938 16 , , , cord-009571-mygj2nd4 938 17 variable variable JJ cord-009571-mygj2nd4 938 18 fall fall NN cord-009571-mygj2nd4 938 19 after after IN cord-009571-mygj2nd4 938 20 2 2 CD cord-009571-mygj2nd4 938 21 to to IN cord-009571-mygj2nd4 938 22 3 3 CD cord-009571-mygj2nd4 938 23 weeks week NNS cord-009571-mygj2nd4 938 24 of of IN cord-009571-mygj2nd4 938 25 treatment treatment NN cord-009571-mygj2nd4 938 26 , , , cord-009571-mygj2nd4 938 27 but but CC cord-009571-mygj2nd4 938 28 no no DT cord-009571-mygj2nd4 938 29 striking strike VBG cord-009571-mygj2nd4 938 30 clinical clinical JJ cord-009571-mygj2nd4 938 31 benefit benefit NN cord-009571-mygj2nd4 938 32 . . . cord-009571-mygj2nd4 939 1 Those those DT cord-009571-mygj2nd4 939 2 cases case NNS cord-009571-mygj2nd4 939 3 with with IN cord-009571-mygj2nd4 939 4 a a DT cord-009571-mygj2nd4 939 5 high high JJ cord-009571-mygj2nd4 939 6 Raji Raji NNP cord-009571-mygj2nd4 939 7 - - HYPH cord-009571-mygj2nd4 939 8 assay assay NN cord-009571-mygj2nd4 939 9 also also RB cord-009571-mygj2nd4 939 10 showed show VBD cord-009571-mygj2nd4 939 11 increased increase VBN cord-009571-mygj2nd4 939 12 binding binding NN cord-009571-mygj2nd4 939 13 of of IN cord-009571-mygj2nd4 939 14 doublestranded doublestranded JJ cord-009571-mygj2nd4 939 15 DNA dna NN cord-009571-mygj2nd4 939 16 . . . cord-009571-mygj2nd4 940 1 The the DT cord-009571-mygj2nd4 940 2 Raji Raji NNP cord-009571-mygj2nd4 940 3 assay assay NN cord-009571-mygj2nd4 940 4 appears appear VBZ cord-009571-mygj2nd4 940 5 to to TO cord-009571-mygj2nd4 940 6 be be VB cord-009571-mygj2nd4 940 7 of of IN cord-009571-mygj2nd4 940 8 value value NN cord-009571-mygj2nd4 940 9 in in IN cord-009571-mygj2nd4 940 10 predicting predict VBG cord-009571-mygj2nd4 940 11 the the DT cord-009571-mygj2nd4 940 12 response response NN cord-009571-mygj2nd4 940 13 to to IN cord-009571-mygj2nd4 940 14 plasmapheresis plasmapheresis NN cord-009571-mygj2nd4 940 15 : : : cord-009571-mygj2nd4 940 16 patients patient NNS cord-009571-mygj2nd4 940 17 with with IN cord-009571-mygj2nd4 940 18 a a DT cord-009571-mygj2nd4 940 19 very very RB cord-009571-mygj2nd4 940 20 high high JJ cord-009571-mygj2nd4 940 21 level level NN cord-009571-mygj2nd4 940 22 may may MD cord-009571-mygj2nd4 940 23 show show VB cord-009571-mygj2nd4 940 24 a a DT cord-009571-mygj2nd4 940 25 massive massive JJ cord-009571-mygj2nd4 940 26 and and CC cord-009571-mygj2nd4 940 27 sustained sustained JJ cord-009571-mygj2nd4 940 28 reduction reduction NN cord-009571-mygj2nd4 940 29 , , , cord-009571-mygj2nd4 940 30 with with IN cord-009571-mygj2nd4 940 31 a a DT cord-009571-mygj2nd4 940 32 good good JJ cord-009571-mygj2nd4 940 33 clinical clinical JJ cord-009571-mygj2nd4 940 34 response response NN cord-009571-mygj2nd4 940 35 . . . cord-009571-mygj2nd4 941 1 In in IN cord-009571-mygj2nd4 941 2 those those DT cord-009571-mygj2nd4 941 3 with with IN cord-009571-mygj2nd4 941 4 lower low JJR cord-009571-mygj2nd4 941 5 levels level NNS cord-009571-mygj2nd4 941 6 , , , cord-009571-mygj2nd4 941 7 the the DT cord-009571-mygj2nd4 941 8 response response NN cord-009571-mygj2nd4 941 9 is be VBZ cord-009571-mygj2nd4 941 10 less less RBR cord-009571-mygj2nd4 941 11 predictable predictable JJ cord-009571-mygj2nd4 941 12 . . . cord-009571-mygj2nd4 942 1 Plasmapheresis Plasmapheresis NNP cord-009571-mygj2nd4 942 2 appears appear VBZ cord-009571-mygj2nd4 942 3 to to TO cord-009571-mygj2nd4 942 4 be be VB cord-009571-mygj2nd4 942 5 a a DT cord-009571-mygj2nd4 942 6 valuable valuable JJ cord-009571-mygj2nd4 942 7 accessory accessory NN cord-009571-mygj2nd4 942 8 form form NN cord-009571-mygj2nd4 942 9 of of IN cord-009571-mygj2nd4 942 10 therapy therapy NN cord-009571-mygj2nd4 942 11 in in IN cord-009571-mygj2nd4 942 12 the the DT cord-009571-mygj2nd4 942 13 severely severely RB cord-009571-mygj2nd4 942 14 ill ill JJ cord-009571-mygj2nd4 942 15 patient patient NN cord-009571-mygj2nd4 942 16 with with IN cord-009571-mygj2nd4 942 17 acute acute JJ cord-009571-mygj2nd4 942 18 SLE SLE NNP cord-009571-mygj2nd4 942 19 . . . cord-009571-mygj2nd4 943 1 To to TO cord-009571-mygj2nd4 943 2 investigate investigate VB cord-009571-mygj2nd4 943 3 the the DT cord-009571-mygj2nd4 943 4 vascular vascular JJ cord-009571-mygj2nd4 943 5 lesion lesion NN cord-009571-mygj2nd4 943 6 in in IN cord-009571-mygj2nd4 943 7 scleroderma scleroderma NN cord-009571-mygj2nd4 943 8 ( ( -LRB- cord-009571-mygj2nd4 943 9 SD SD NNP cord-009571-mygj2nd4 943 10 ) ) -RRB- cord-009571-mygj2nd4 943 11 , , , cord-009571-mygj2nd4 943 12 the the DT cord-009571-mygj2nd4 943 13 effect effect NN cord-009571-mygj2nd4 943 14 on on IN cord-009571-mygj2nd4 943 15 human human JJ cord-009571-mygj2nd4 943 16 endothelial endothelial JJ cord-009571-mygj2nd4 943 17 cell cell NN cord-009571-mygj2nd4 943 18 ( ( -LRB- cord-009571-mygj2nd4 943 19 EC EC NNP cord-009571-mygj2nd4 943 20 , , , cord-009571-mygj2nd4 943 21 umbilical umbilical JJ cord-009571-mygj2nd4 943 22 cord cord NN cord-009571-mygj2nd4 943 23 ) ) -RRB- cord-009571-mygj2nd4 943 24 growth growth NN cord-009571-mygj2nd4 943 25 of of IN cord-009571-mygj2nd4 943 26 sera sera NNP cord-009571-mygj2nd4 943 27 from from IN cord-009571-mygj2nd4 943 28 21 21 CD cord-009571-mygj2nd4 943 29 patients patient NNS cord-009571-mygj2nd4 943 30 with with IN cord-009571-mygj2nd4 943 31 early early JJ cord-009571-mygj2nd4 943 32 SD sd NN cord-009571-mygj2nd4 943 33 was be VBD cord-009571-mygj2nd4 943 34 compared compare VBN cord-009571-mygj2nd4 943 35 with with IN cord-009571-mygj2nd4 943 36 10 10 CD cord-009571-mygj2nd4 943 37 healthy healthy JJ cord-009571-mygj2nd4 943 38 control control NN cord-009571-mygj2nd4 943 39 sera sera NNP cord-009571-mygj2nd4 943 40 . . . cord-009571-mygj2nd4 944 1 EC EC NNP cord-009571-mygj2nd4 944 2 growth growth NN cord-009571-mygj2nd4 944 3 was be VBD cord-009571-mygj2nd4 944 4 monitored monitor VBN cord-009571-mygj2nd4 944 5 by by IN cord-009571-mygj2nd4 944 6 tritiated tritiate VBN cord-009571-mygj2nd4 944 7 thymidine thymidine NN cord-009571-mygj2nd4 944 8 CHTdR CHTdR NNP cord-009571-mygj2nd4 944 9 ) ) -RRB- cord-009571-mygj2nd4 944 10 uptake uptake NN cord-009571-mygj2nd4 944 11 and and CC cord-009571-mygj2nd4 944 12 by by IN cord-009571-mygj2nd4 944 13 direct direct JJ cord-009571-mygj2nd4 944 14 cell cell NN cord-009571-mygj2nd4 944 15 counts count NNS cord-009571-mygj2nd4 944 16 . . . cord-009571-mygj2nd4 945 1 SHTdR SHTdR NNP cord-009571-mygj2nd4 945 2 uptake uptake NN cord-009571-mygj2nd4 945 3 of of IN cord-009571-mygj2nd4 945 4 EC EC NNP cord-009571-mygj2nd4 945 5 was be VBD cord-009571-mygj2nd4 945 6 inhibited inhibit VBN cord-009571-mygj2nd4 945 7 up up RP cord-009571-mygj2nd4 945 8 to to TO cord-009571-mygj2nd4 945 9 97 97 CD cord-009571-mygj2nd4 945 10 % % NN cord-009571-mygj2nd4 945 11 by by IN cord-009571-mygj2nd4 945 12 11 11 CD cord-009571-mygj2nd4 945 13 of of IN cord-009571-mygj2nd4 945 14 21 21 CD cord-009571-mygj2nd4 945 15 SD SD NNP cord-009571-mygj2nd4 945 16 sera sera NNP cord-009571-mygj2nd4 945 17 compared compare VBN cord-009571-mygj2nd4 945 18 to to IN cord-009571-mygj2nd4 945 19 the the DT cord-009571-mygj2nd4 945 20 remaining remain VBG cord-009571-mygj2nd4 945 21 10 10 CD cord-009571-mygj2nd4 945 22 SD sd NN cord-009571-mygj2nd4 945 23 and and CC cord-009571-mygj2nd4 945 24 10 10 CD cord-009571-mygj2nd4 945 25 control control NN cord-009571-mygj2nd4 945 26 sera sera NNP cord-009571-mygj2nd4 945 27 . . . cord-009571-mygj2nd4 946 1 Mean mean JJ cord-009571-mygj2nd4 946 2 8HTdR 8htdr CD cord-009571-mygj2nd4 946 3 uptake uptake NN cord-009571-mygj2nd4 946 4 was be VBD cord-009571-mygj2nd4 946 5 2747 2747 CD cord-009571-mygj2nd4 946 6 cpm cpm NNP cord-009571-mygj2nd4 946 7 for for IN cord-009571-mygj2nd4 946 8 control control NNP cord-009571-mygj2nd4 946 9 sera sera NNP cord-009571-mygj2nd4 947 1 ( ( -LRB- cord-009571-mygj2nd4 947 2 range range NN cord-009571-mygj2nd4 947 3 : : : cord-009571-mygj2nd4 947 4 1130 1130 CD cord-009571-mygj2nd4 947 5 - - SYM cord-009571-mygj2nd4 947 6 575l 575l CD cord-009571-mygj2nd4 947 7 ) ) -RRB- cord-009571-mygj2nd4 947 8 , , . cord-009571-mygj2nd4 948 1 2448 2448 CD cord-009571-mygj2nd4 948 2 cpm cpm NNP cord-009571-mygj2nd4 948 3 for for IN cord-009571-mygj2nd4 948 4 the the DT cord-009571-mygj2nd4 948 5 10 10 CD cord-009571-mygj2nd4 948 6 noninhibitory noninhibitory NNP cord-009571-mygj2nd4 948 7 SD SD NNP cord-009571-mygj2nd4 948 8 sera sera NNP cord-009571-mygj2nd4 948 9 ( ( -LRB- cord-009571-mygj2nd4 948 10 989 989 CD cord-009571-mygj2nd4 948 11 - - HYPH cord-009571-mygj2nd4 948 12 5162 5162 CD cord-009571-mygj2nd4 948 13 ) ) -RRB- cord-009571-mygj2nd4 948 14 . . . cord-009571-mygj2nd4 949 1 and and CC cord-009571-mygj2nd4 949 2 182 182 CD cord-009571-mygj2nd4 949 3 cpm cpm NNS cord-009571-mygj2nd4 949 4 for for IN cord-009571-mygj2nd4 949 5 the the DT cord-009571-mygj2nd4 949 6 I i NN cord-009571-mygj2nd4 949 7 I -PRON- PRP cord-009571-mygj2nd4 949 8 inhibitory inhibitory JJ cord-009571-mygj2nd4 949 9 SD sd NN cord-009571-mygj2nd4 949 10 sera sera NNP cord-009571-mygj2nd4 949 11 ( ( -LRB- cord-009571-mygj2nd4 949 12 58 58 CD cord-009571-mygj2nd4 949 13 - - SYM cord-009571-mygj2nd4 949 14 424 424 CD cord-009571-mygj2nd4 949 15 ) ) -RRB- cord-009571-mygj2nd4 949 16 . . . cord-009571-mygj2nd4 950 1 The the DT cord-009571-mygj2nd4 950 2 SD SD NNP cord-009571-mygj2nd4 950 3 patients patient NNS cord-009571-mygj2nd4 950 4 with with IN cord-009571-mygj2nd4 950 5 inhibitory inhibitory JJ cord-009571-mygj2nd4 950 6 serum serum NN cord-009571-mygj2nd4 950 7 activity activity NN cord-009571-mygj2nd4 950 8 tended tend VBD cord-009571-mygj2nd4 950 9 toward toward IN cord-009571-mygj2nd4 950 10 shorter short JJR cord-009571-mygj2nd4 950 11 disease disease NN cord-009571-mygj2nd4 950 12 and and CC cord-009571-mygj2nd4 950 13 symptom symptom NN cord-009571-mygj2nd4 950 14 duration duration NN cord-009571-mygj2nd4 950 15 and and CC cord-009571-mygj2nd4 950 16 were be VBD cord-009571-mygj2nd4 950 17 more more RBR cord-009571-mygj2nd4 950 18 likely likely JJ cord-009571-mygj2nd4 950 19 to to TO cord-009571-mygj2nd4 950 20 have have VB cord-009571-mygj2nd4 950 21 peripheral peripheral JJ cord-009571-mygj2nd4 950 22 edema edema NN cord-009571-mygj2nd4 950 23 and and CC cord-009571-mygj2nd4 950 24 hypergammaglobulinemia hypergammaglobulinemia NN cord-009571-mygj2nd4 950 25 than than IN cord-009571-mygj2nd4 950 26 SD SD NNP cord-009571-mygj2nd4 950 27 patients patient NNS cord-009571-mygj2nd4 950 28 without without IN cord-009571-mygj2nd4 950 29 inhibitory inhibitory JJ cord-009571-mygj2nd4 950 30 activity activity NN cord-009571-mygj2nd4 950 31 . . . cord-009571-mygj2nd4 951 1 Furthermore furthermore RB cord-009571-mygj2nd4 951 2 , , , cord-009571-mygj2nd4 951 3 the the DT cord-009571-mygj2nd4 951 4 inhibitory inhibitory JJ cord-009571-mygj2nd4 951 5 effect effect NN cord-009571-mygj2nd4 951 6 was be VBD cord-009571-mygj2nd4 951 7 no no RB cord-009571-mygj2nd4 951 8 longer long RBR cord-009571-mygj2nd4 951 9 present present JJ cord-009571-mygj2nd4 951 10 in in IN cord-009571-mygj2nd4 951 11 one one CD cord-009571-mygj2nd4 951 12 patient patient NN cord-009571-mygj2nd4 951 13 after after IN cord-009571-mygj2nd4 951 14 therapy therapy NN cord-009571-mygj2nd4 951 15 with with IN cord-009571-mygj2nd4 951 16 glucocorticoids glucocorticoid NNS cord-009571-mygj2nd4 951 17 which which WDT cord-009571-mygj2nd4 951 18 was be VBD cord-009571-mygj2nd4 951 19 associated associate VBN cord-009571-mygj2nd4 951 20 with with IN cord-009571-mygj2nd4 951 21 reduction reduction NN cord-009571-mygj2nd4 951 22 of of IN cord-009571-mygj2nd4 951 23 peripheral peripheral JJ cord-009571-mygj2nd4 951 24 edema edema NN cord-009571-mygj2nd4 951 25 and and CC cord-009571-mygj2nd4 951 26 improvement improvement NN cord-009571-mygj2nd4 951 27 of of IN cord-009571-mygj2nd4 951 28 myositis myositis NN cord-009571-mygj2nd4 951 29 . . . cord-009571-mygj2nd4 952 1 The the DT cord-009571-mygj2nd4 952 2 activity activity NN cord-009571-mygj2nd4 952 3 was be VBD cord-009571-mygj2nd4 952 4 further further RB cord-009571-mygj2nd4 952 5 characterized characterize VBN cord-009571-mygj2nd4 952 6 in in IN cord-009571-mygj2nd4 952 7 selected select VBN cord-009571-mygj2nd4 952 8 sera sera NNP cord-009571-mygj2nd4 952 9 . . . cord-009571-mygj2nd4 953 1 SD SD NNP cord-009571-mygj2nd4 953 2 serum serum NN cord-009571-mygj2nd4 953 3 completely completely RB cord-009571-mygj2nd4 953 4 inhibited inhibit VBD cord-009571-mygj2nd4 953 5 the the DT cord-009571-mygj2nd4 953 6 increase increase NN cord-009571-mygj2nd4 953 7 in in IN cord-009571-mygj2nd4 953 8 EC EC NNP cord-009571-mygj2nd4 953 9 8HTdR 8htdr CD cord-009571-mygj2nd4 953 10 uptake uptake NN cord-009571-mygj2nd4 953 11 seen see VBN cord-009571-mygj2nd4 953 12 with with IN cord-009571-mygj2nd4 953 13 increasing increase VBG cord-009571-mygj2nd4 953 14 normal normal JJ cord-009571-mygj2nd4 953 15 serum serum NN cord-009571-mygj2nd4 953 16 concentration concentration NN cord-009571-mygj2nd4 953 17 from from IN cord-009571-mygj2nd4 953 18 2 2 CD cord-009571-mygj2nd4 953 19 to to IN cord-009571-mygj2nd4 953 20 25 25 CD cord-009571-mygj2nd4 953 21 % % NN cord-009571-mygj2nd4 953 22 . . . cord-009571-mygj2nd4 954 1 8HTdR 8htdr CD cord-009571-mygj2nd4 954 2 uptake uptake NN cord-009571-mygj2nd4 954 3 correlated correlate VBN cord-009571-mygj2nd4 954 4 with with IN cord-009571-mygj2nd4 954 5 reduction reduction NN cord-009571-mygj2nd4 954 6 in in IN cord-009571-mygj2nd4 954 7 EC EC NNP cord-009571-mygj2nd4 954 8 number number NN cord-009571-mygj2nd4 954 9 ( ( -LRB- cord-009571-mygj2nd4 954 10 30 30 CD cord-009571-mygj2nd4 954 11 % % NN cord-009571-mygj2nd4 954 12 reduction reduction NN cord-009571-mygj2nd4 954 13 at at IN cord-009571-mygj2nd4 954 14 20 20 CD cord-009571-mygj2nd4 954 15 % % NN cord-009571-mygj2nd4 954 16 SD sd NN cord-009571-mygj2nd4 954 17 serum serum NN cord-009571-mygj2nd4 954 18 concentration concentration NN cord-009571-mygj2nd4 954 19 versus versus IN cord-009571-mygj2nd4 954 20 100 100 CD cord-009571-mygj2nd4 954 21 % % NN cord-009571-mygj2nd4 954 22 increase increase NN cord-009571-mygj2nd4 954 23 with with IN cord-009571-mygj2nd4 954 24 control control NN cord-009571-mygj2nd4 954 25 serum serum NN cord-009571-mygj2nd4 954 26 ) ) -RRB- cord-009571-mygj2nd4 954 27 and and CC cord-009571-mygj2nd4 954 28 with with IN cord-009571-mygj2nd4 954 29 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 954 30 ( ( -LRB- cord-009571-mygj2nd4 954 31 52 52 CD cord-009571-mygj2nd4 954 32 % % NN cord-009571-mygj2nd4 954 33 cell cell NN cord-009571-mygj2nd4 954 34 death death NN cord-009571-mygj2nd4 954 35 versus versus IN cord-009571-mygj2nd4 954 36 6 6 CD cord-009571-mygj2nd4 954 37 % % NN cord-009571-mygj2nd4 954 38 in in IN cord-009571-mygj2nd4 954 39 control control NN cord-009571-mygj2nd4 954 40 serum serum NN cord-009571-mygj2nd4 954 41 ) ) -RRB- cord-009571-mygj2nd4 954 42 . . . cord-009571-mygj2nd4 955 1 These these DT cord-009571-mygj2nd4 955 2 effects effect NNS cord-009571-mygj2nd4 955 3 were be VBD cord-009571-mygj2nd4 955 4 not not RB cord-009571-mygj2nd4 955 5 observed observe VBN cord-009571-mygj2nd4 955 6 when when WRB cord-009571-mygj2nd4 955 7 the the DT cord-009571-mygj2nd4 955 8 target target NN cord-009571-mygj2nd4 955 9 cells cell NNS cord-009571-mygj2nd4 955 10 were be VBD cord-009571-mygj2nd4 955 11 mouse mouse NN cord-009571-mygj2nd4 955 12 3T3 3t3 CD cord-009571-mygj2nd4 955 13 or or CC cord-009571-mygj2nd4 955 14 human human JJ cord-009571-mygj2nd4 955 15 fibroblasts fibroblast NNS cord-009571-mygj2nd4 955 16 , , , cord-009571-mygj2nd4 955 17 smooth smooth JJ cord-009571-mygj2nd4 955 18 muscle muscle NN cord-009571-mygj2nd4 955 19 cells cell NNS cord-009571-mygj2nd4 955 20 , , , cord-009571-mygj2nd4 955 21 or or CC cord-009571-mygj2nd4 955 22 peripheral peripheral JJ cord-009571-mygj2nd4 955 23 monocytes monocyte NNS cord-009571-mygj2nd4 955 24 , , , cord-009571-mygj2nd4 955 25 suggesting suggest VBG cord-009571-mygj2nd4 955 26 specificity specificity NN cord-009571-mygj2nd4 955 27 of of IN cord-009571-mygj2nd4 955 28 the the DT cord-009571-mygj2nd4 955 29 inhibitory inhibitory JJ cord-009571-mygj2nd4 955 30 effect effect NN cord-009571-mygj2nd4 955 31 of of IN cord-009571-mygj2nd4 955 32 SD SD NNP cord-009571-mygj2nd4 955 33 sera sera NNP cord-009571-mygj2nd4 955 34 for for IN cord-009571-mygj2nd4 955 35 EC EC NNP cord-009571-mygj2nd4 955 36 . . . cord-009571-mygj2nd4 956 1 The the DT cord-009571-mygj2nd4 956 2 inhibitory inhibitory JJ cord-009571-mygj2nd4 956 3 effect effect NN cord-009571-mygj2nd4 956 4 of of IN cord-009571-mygj2nd4 956 5 SD sd NN cord-009571-mygj2nd4 956 6 serum serum NN cord-009571-mygj2nd4 956 7 was be VBD cord-009571-mygj2nd4 956 8 heat heat NN cord-009571-mygj2nd4 956 9 stable stable JJ cord-009571-mygj2nd4 956 10 ( ( -LRB- cord-009571-mygj2nd4 956 11 56"C 56"c CD cord-009571-mygj2nd4 956 12 , , , cord-009571-mygj2nd4 956 13 30 30 CD cord-009571-mygj2nd4 956 14 minutes minute NNS cord-009571-mygj2nd4 956 15 ) ) -RRB- cord-009571-mygj2nd4 956 16 , , , cord-009571-mygj2nd4 956 17 nondialyzable nondialyzable NNP cord-009571-mygj2nd4 956 18 , , , cord-009571-mygj2nd4 956 19 present present JJ cord-009571-mygj2nd4 956 20 in in IN cord-009571-mygj2nd4 956 21 both both CC cord-009571-mygj2nd4 956 22 plasma plasma NN cord-009571-mygj2nd4 956 23 and and CC cord-009571-mygj2nd4 956 24 serum serum NN cord-009571-mygj2nd4 956 25 , , , cord-009571-mygj2nd4 956 26 and and CC cord-009571-mygj2nd4 956 27 unaffected unaffected JJ cord-009571-mygj2nd4 956 28 by by IN cord-009571-mygj2nd4 956 29 mixing mix VBG cord-009571-mygj2nd4 956 30 with with IN cord-009571-mygj2nd4 956 31 control control NN cord-009571-mygj2nd4 956 32 serum serum NN cord-009571-mygj2nd4 956 33 . . . cord-009571-mygj2nd4 957 1 When when WRB cord-009571-mygj2nd4 957 2 serum serum NN cord-009571-mygj2nd4 957 3 was be VBD cord-009571-mygj2nd4 957 4 fractionated fractionate VBN cord-009571-mygj2nd4 957 5 on on IN cord-009571-mygj2nd4 957 6 Sephadex Sephadex NNP cord-009571-mygj2nd4 957 7 G-200 g-200 DT cord-009571-mygj2nd4 957 8 column column NN cord-009571-mygj2nd4 957 9 , , , cord-009571-mygj2nd4 957 10 the the DT cord-009571-mygj2nd4 957 11 inhibitory inhibitory JJ cord-009571-mygj2nd4 957 12 activity activity NN cord-009571-mygj2nd4 957 13 was be VBD cord-009571-mygj2nd4 957 14 found find VBN cord-009571-mygj2nd4 957 15 to to TO cord-009571-mygj2nd4 957 16 elute elute VB cord-009571-mygj2nd4 957 17 in in IN cord-009571-mygj2nd4 957 18 the the DT cord-009571-mygj2nd4 957 19 position position NN cord-009571-mygj2nd4 957 20 of of IN cord-009571-mygj2nd4 957 21 serum serum NN cord-009571-mygj2nd4 957 22 albumin albumin NN cord-009571-mygj2nd4 957 23 . . . cord-009571-mygj2nd4 958 1 Sera Sera NNP cord-009571-mygj2nd4 958 2 from from IN cord-009571-mygj2nd4 958 3 7 7 CD cord-009571-mygj2nd4 958 4 patients patient NNS cord-009571-mygj2nd4 958 5 with with IN cord-009571-mygj2nd4 958 6 non non JJ cord-009571-mygj2nd4 958 7 - - JJ cord-009571-mygj2nd4 958 8 SD sd JJ cord-009571-mygj2nd4 958 9 active active JJ cord-009571-mygj2nd4 958 10 rheumatic rheumatic JJ cord-009571-mygj2nd4 958 11 diseases disease NNS cord-009571-mygj2nd4 958 12 ( ( -LRB- cord-009571-mygj2nd4 958 13 RA RA NNP cord-009571-mygj2nd4 958 14 , , , cord-009571-mygj2nd4 958 15 SLE SLE NNP cord-009571-mygj2nd4 958 16 , , , cord-009571-mygj2nd4 958 17 PAN PAN NNP cord-009571-mygj2nd4 958 18 , , , cord-009571-mygj2nd4 958 19 DM DM NNP cord-009571-mygj2nd4 958 20 ) ) -RRB- cord-009571-mygj2nd4 958 21 showed show VBD cord-009571-mygj2nd4 958 22 no no DT cord-009571-mygj2nd4 958 23 inhibitory inhibitory JJ cord-009571-mygj2nd4 958 24 effect effect NN cord-009571-mygj2nd4 958 25 on on IN cord-009571-mygj2nd4 958 26 human human JJ cord-009571-mygj2nd4 958 27 EC EC NNP cord-009571-mygj2nd4 958 28 , , , cord-009571-mygj2nd4 958 29 fibroblasts fibroblast NNS cord-009571-mygj2nd4 958 30 or or CC cord-009571-mygj2nd4 958 31 smooth smooth JJ cord-009571-mygj2nd4 958 32 muscle muscle NN cord-009571-mygj2nd4 958 33 cells cell NNS cord-009571-mygj2nd4 958 34 or or CC cord-009571-mygj2nd4 958 35 mouse mouse NN cord-009571-mygj2nd4 958 36 3T3 3t3 CD cord-009571-mygj2nd4 958 37 cells cell NNS cord-009571-mygj2nd4 958 38 . . . cord-009571-mygj2nd4 959 1 These these DT cord-009571-mygj2nd4 959 2 preliminary preliminary JJ cord-009571-mygj2nd4 959 3 observations observation NNS cord-009571-mygj2nd4 959 4 describe describe VBP cord-009571-mygj2nd4 959 5 an an DT cord-009571-mygj2nd4 959 6 EC EC NNP cord-009571-mygj2nd4 959 7 - - HYPH cord-009571-mygj2nd4 959 8 specific specific JJ cord-009571-mygj2nd4 959 9 cytotoxic cytotoxic JJ cord-009571-mygj2nd4 959 10 serum serum NN cord-009571-mygj2nd4 959 11 factor(s factor(s NNP cord-009571-mygj2nd4 959 12 ) ) -RRB- cord-009571-mygj2nd4 959 13 in in IN cord-009571-mygj2nd4 959 14 patients patient NNS cord-009571-mygj2nd4 959 15 with with IN cord-009571-mygj2nd4 959 16 SD SD NNP cord-009571-mygj2nd4 959 17 . . . cord-009571-mygj2nd4 960 1 The the DT cord-009571-mygj2nd4 960 2 in in IN cord-009571-mygj2nd4 960 3 vivo vivo NN cord-009571-mygj2nd4 960 4 role role NN cord-009571-mygj2nd4 960 5 of of IN cord-009571-mygj2nd4 960 6 this this DT cord-009571-mygj2nd4 960 7 factor(s factor(s NNP cord-009571-mygj2nd4 960 8 ) ) -RRB- cord-009571-mygj2nd4 960 9 in in IN cord-009571-mygj2nd4 960 10 the the DT cord-009571-mygj2nd4 960 11 pathogenesis pathogenesis NN cord-009571-mygj2nd4 960 12 of of IN cord-009571-mygj2nd4 960 13 the the DT cord-009571-mygj2nd4 960 14 proliferative proliferative JJ cord-009571-mygj2nd4 960 15 vascular vascular JJ cord-009571-mygj2nd4 960 16 lesions lesion NNS cord-009571-mygj2nd4 960 17 in in IN cord-009571-mygj2nd4 960 18 scleroderma scleroderma NN cord-009571-mygj2nd4 960 19 is be VBZ cord-009571-mygj2nd4 960 20 unknown unknown JJ cord-009571-mygj2nd4 960 21 . . . cord-009571-mygj2nd4 961 1 Activation activation NN cord-009571-mygj2nd4 961 2 ? ? . cord-009571-mygj2nd4 962 1 Activation activation NN cord-009571-mygj2nd4 962 2 of of IN cord-009571-mygj2nd4 962 3 the the DT cord-009571-mygj2nd4 962 4 complement complement NN cord-009571-mygj2nd4 962 5 ( ( -LRB- cord-009571-mygj2nd4 962 6 C c NN cord-009571-mygj2nd4 962 7 ) ) -RRB- cord-009571-mygj2nd4 962 8 system system NN cord-009571-mygj2nd4 962 9 in in IN cord-009571-mygj2nd4 962 10 RA RA NNP cord-009571-mygj2nd4 962 11 has have VBZ cord-009571-mygj2nd4 962 12 been be VBN cord-009571-mygj2nd4 962 13 amply amply RB cord-009571-mygj2nd4 962 14 evidenced evidence VBN cord-009571-mygj2nd4 962 15 by by IN cord-009571-mygj2nd4 962 16 a a DT cord-009571-mygj2nd4 962 17 ) ) -RRB- cord-009571-mygj2nd4 962 18 detection detection NN cord-009571-mygj2nd4 962 19 of of IN cord-009571-mygj2nd4 962 20 C c NN cord-009571-mygj2nd4 962 21 and and CC cord-009571-mygj2nd4 962 22 immune immune JJ cord-009571-mygj2nd4 962 23 complexes complex NNS cord-009571-mygj2nd4 962 24 in in IN cord-009571-mygj2nd4 962 25 RA RA NNP cord-009571-mygj2nd4 962 26 synovial synovial JJ cord-009571-mygj2nd4 962 27 leukocyte leukocyte NN cord-009571-mygj2nd4 962 28 inclusions inclusion NNS cord-009571-mygj2nd4 962 29 ; ; : cord-009571-mygj2nd4 962 30 b b LS cord-009571-mygj2nd4 962 31 ) ) -RRB- cord-009571-mygj2nd4 962 32 depressed depressed JJ cord-009571-mygj2nd4 962 33 CH50 CH50 NNP cord-009571-mygj2nd4 962 34 , , , cord-009571-mygj2nd4 962 35 C4 c4 NN cord-009571-mygj2nd4 962 36 , , , cord-009571-mygj2nd4 962 37 and and CC cord-009571-mygj2nd4 962 38 C2 C2 NNP cord-009571-mygj2nd4 962 39 levels level NNS cord-009571-mygj2nd4 962 40 as as RB cord-009571-mygj2nd4 962 41 well well RB cord-009571-mygj2nd4 962 42 as as IN cord-009571-mygj2nd4 962 43 split split VBN cord-009571-mygj2nd4 962 44 products product NNS cord-009571-mygj2nd4 962 45 of of IN cord-009571-mygj2nd4 962 46 C3 C3 NNP cord-009571-mygj2nd4 962 47 , , , cord-009571-mygj2nd4 962 48 C4 C4 NNP cord-009571-mygj2nd4 962 49 , , , cord-009571-mygj2nd4 962 50 and and CC cord-009571-mygj2nd4 962 51 FB fb NN cord-009571-mygj2nd4 962 52 in in IN cord-009571-mygj2nd4 962 53 RA RA NNP cord-009571-mygj2nd4 962 54 synovial synovial JJ cord-009571-mygj2nd4 962 55 fluids fluid NNS cord-009571-mygj2nd4 962 56 ; ; : cord-009571-mygj2nd4 962 57 c c LS cord-009571-mygj2nd4 962 58 ) ) -RRB- cord-009571-mygj2nd4 962 59 split split NN cord-009571-mygj2nd4 962 60 products product NNS cord-009571-mygj2nd4 962 61 of of IN cord-009571-mygj2nd4 962 62 C3 c3 NN cord-009571-mygj2nd4 962 63 and and CC cord-009571-mygj2nd4 962 64 C4 c4 NN cord-009571-mygj2nd4 962 65 in in IN cord-009571-mygj2nd4 962 66 RA RA NNP cord-009571-mygj2nd4 962 67 plasma plasma NN cord-009571-mygj2nd4 962 68 samples sample NNS cord-009571-mygj2nd4 962 69 ; ; : cord-009571-mygj2nd4 962 70 and and CC cord-009571-mygj2nd4 962 71 d d LS cord-009571-mygj2nd4 962 72 ) ) -RRB- cord-009571-mygj2nd4 962 73 hypercatabolism hypercatabolism NN cord-009571-mygj2nd4 962 74 of of IN cord-009571-mygj2nd4 962 75 C3 C3 NNP cord-009571-mygj2nd4 962 76 in in IN cord-009571-mygj2nd4 962 77 meta meta JJ cord-009571-mygj2nd4 962 78 - - HYPH cord-009571-mygj2nd4 962 79 bolic bolic JJ cord-009571-mygj2nd4 962 80 turnover turnover NN cord-009571-mygj2nd4 962 81 studies study NNS cord-009571-mygj2nd4 962 82 . . . cord-009571-mygj2nd4 963 1 We -PRON- PRP cord-009571-mygj2nd4 963 2 measured measure VBD cord-009571-mygj2nd4 963 3 the the DT cord-009571-mygj2nd4 963 4 fractional fractional JJ cord-009571-mygj2nd4 963 5 catabolic catabolic JJ cord-009571-mygj2nd4 963 6 rates rate NNS cord-009571-mygj2nd4 963 7 ( ( -LRB- cord-009571-mygj2nd4 963 8 FCR FCR NNP cord-009571-mygj2nd4 963 9 ) ) -RRB- cord-009571-mygj2nd4 963 10 of of IN cord-009571-mygj2nd4 963 11 radioactive radioactive JJ cord-009571-mygj2nd4 963 12 labeled label VBN cord-009571-mygj2nd4 963 13 C4 c4 NN cord-009571-mygj2nd4 963 14 and and CC cord-009571-mygj2nd4 963 15 FB fb NN cord-009571-mygj2nd4 963 16 in in IN cord-009571-mygj2nd4 963 17 RA RA NNP cord-009571-mygj2nd4 963 18 patients patient NNS cord-009571-mygj2nd4 963 19 and and CC cord-009571-mygj2nd4 963 20 normal normal JJ cord-009571-mygj2nd4 963 21 controls control NNS cord-009571-mygj2nd4 963 22 to to TO cord-009571-mygj2nd4 963 23 assess assess VB cord-009571-mygj2nd4 963 24 the the DT cord-009571-mygj2nd4 963 25 relative relative JJ cord-009571-mygj2nd4 963 26 importance importance NN cord-009571-mygj2nd4 963 27 of of IN cord-009571-mygj2nd4 963 28 classical classical JJ cord-009571-mygj2nd4 963 29 and and CC cord-009571-mygj2nd4 963 30 alternative alternative JJ cord-009571-mygj2nd4 963 31 pathways pathway NNS cord-009571-mygj2nd4 963 32 of of IN cord-009571-mygj2nd4 963 33 complement complement JJ cord-009571-mygj2nd4 963 34 activation activation NN cord-009571-mygj2nd4 963 35 in in IN cord-009571-mygj2nd4 963 36 RA RA NNP cord-009571-mygj2nd4 963 37 . . . cord-009571-mygj2nd4 964 1 Our -PRON- PRP$ cord-009571-mygj2nd4 964 2 results result NNS cord-009571-mygj2nd4 964 3 demonstrated demonstrate VBD cord-009571-mygj2nd4 964 4 : : : cord-009571-mygj2nd4 964 5 1 1 LS cord-009571-mygj2nd4 964 6 ) ) -RRB- cord-009571-mygj2nd4 964 7 hypercatabolism hypercatabolism NN cord-009571-mygj2nd4 964 8 of of IN cord-009571-mygj2nd4 964 9 C4 C4 NNP cord-009571-mygj2nd4 964 10 in in IN cord-009571-mygj2nd4 964 11 10 10 CD cord-009571-mygj2nd4 964 12 of of IN cord-009571-mygj2nd4 964 13 15 15 CD cord-009571-mygj2nd4 964 14 RA RA NNP cord-009571-mygj2nd4 964 15 subjects subject NNS cord-009571-mygj2nd4 964 16 and and CC cord-009571-mygj2nd4 964 17 inverse inverse JJ cord-009571-mygj2nd4 964 18 variation variation NN cord-009571-mygj2nd4 964 19 of of IN cord-009571-mygj2nd4 964 20 C4 c4 NN cord-009571-mygj2nd4 964 21 FCR FCR NNP cord-009571-mygj2nd4 964 22 with with IN cord-009571-mygj2nd4 964 23 plasma plasma NN cord-009571-mygj2nd4 964 24 C4 c4 NN cord-009571-mygj2nd4 964 25 levels level NNS cord-009571-mygj2nd4 964 26 ; ; : cord-009571-mygj2nd4 964 27 2 2 LS cord-009571-mygj2nd4 964 28 ) ) -RRB- cord-009571-mygj2nd4 964 29 hypercatabolism hypercatabolism NN cord-009571-mygj2nd4 964 30 of of IN cord-009571-mygj2nd4 964 31 F F NNP cord-009571-mygj2nd4 964 32 C C NNP cord-009571-mygj2nd4 964 33 in in IN cord-009571-mygj2nd4 964 34 5 5 CD cord-009571-mygj2nd4 964 35 of of IN cord-009571-mygj2nd4 964 36 10 10 CD cord-009571-mygj2nd4 964 37 RA RA NNP cord-009571-mygj2nd4 964 38 patients patient NNS cord-009571-mygj2nd4 964 39 ; ; : cord-009571-mygj2nd4 964 40 3 3 CD cord-009571-mygj2nd4 964 41 ) ) -RRB- cord-009571-mygj2nd4 964 42 C4 c4 NN cord-009571-mygj2nd4 964 43 FCRs fcr NNS cord-009571-mygj2nd4 964 44 disproportionately disproportionately RB cord-009571-mygj2nd4 964 45 higher high JJR cord-009571-mygj2nd4 964 46 than than IN cord-009571-mygj2nd4 964 47 FB FB NNP cord-009571-mygj2nd4 964 48 FCRs fcr NNS cord-009571-mygj2nd4 964 49 in in IN cord-009571-mygj2nd4 964 50 3 3 CD cord-009571-mygj2nd4 964 51 of of IN cord-009571-mygj2nd4 964 52 5 5 CD cord-009571-mygj2nd4 964 53 RA RA NNP cord-009571-mygj2nd4 964 54 subjects subject NNS cord-009571-mygj2nd4 964 55 undergoing undergo VBG cord-009571-mygj2nd4 964 56 simultaneous simultaneous JJ cord-009571-mygj2nd4 964 57 studies study NNS cord-009571-mygj2nd4 964 58 ; ; : cord-009571-mygj2nd4 964 59 4 4 LS cord-009571-mygj2nd4 964 60 ) ) -RRB- cord-009571-mygj2nd4 964 61 correlation correlation NN cord-009571-mygj2nd4 964 62 of of IN cord-009571-mygj2nd4 964 63 C4 c4 NN cord-009571-mygj2nd4 964 64 and and CC cord-009571-mygj2nd4 964 65 FB fb NN cord-009571-mygj2nd4 964 66 catabolism catabolism NN cord-009571-mygj2nd4 964 67 and and CC cord-009571-mygj2nd4 964 68 homologous homologous JJ cord-009571-mygj2nd4 964 69 IgG igg NN cord-009571-mygj2nd4 964 70 catabolism catabolism NN cord-009571-mygj2nd4 964 71 ; ; : cord-009571-mygj2nd4 964 72 and and CC cord-009571-mygj2nd4 964 73 5 5 LS cord-009571-mygj2nd4 964 74 ) ) -RRB- cord-009571-mygj2nd4 964 75 occurrence occurrence NN cord-009571-mygj2nd4 964 76 of of IN cord-009571-mygj2nd4 964 77 hypercatabolism hypercatabolism NN cord-009571-mygj2nd4 964 78 of of IN cord-009571-mygj2nd4 964 79 C4 C4 NNP cord-009571-mygj2nd4 964 80 mostly mostly RB cord-009571-mygj2nd4 964 81 in in IN cord-009571-mygj2nd4 964 82 the the DT cord-009571-mygj2nd4 964 83 extravascular extravascular NNP cord-009571-mygj2nd4 964 84 space space NN cord-009571-mygj2nd4 964 85 , , , cord-009571-mygj2nd4 964 86 a a DT cord-009571-mygj2nd4 964 87 phenomenon phenomenon NN cord-009571-mygj2nd4 964 88 previously previously RB cord-009571-mygj2nd4 964 89 observed observe VBN cord-009571-mygj2nd4 964 90 by by IN cord-009571-mygj2nd4 964 91 us -PRON- PRP cord-009571-mygj2nd4 964 92 also also RB cord-009571-mygj2nd4 964 93 with with IN cord-009571-mygj2nd4 964 94 the the DT cord-009571-mygj2nd4 964 95 IgG IgG NNP cord-009571-mygj2nd4 964 96 hypercatabolism hypercatabolism NN cord-009571-mygj2nd4 964 97 of of IN cord-009571-mygj2nd4 964 98 RA RA NNP cord-009571-mygj2nd4 964 99 . . . cord-009571-mygj2nd4 965 1 Patients patient NNS cord-009571-mygj2nd4 965 2 with with IN cord-009571-mygj2nd4 965 3 high high JJ cord-009571-mygj2nd4 965 4 FB fb NN cord-009571-mygj2nd4 965 5 FCRs fcr NNS cord-009571-mygj2nd4 965 6 had have VBD cord-009571-mygj2nd4 965 7 higher high JJR cord-009571-mygj2nd4 965 8 titers titer NNS cord-009571-mygj2nd4 965 9 for for IN cord-009571-mygj2nd4 965 10 rheumatoid rheumatoid NN cord-009571-mygj2nd4 965 11 factors factor NNS cord-009571-mygj2nd4 965 12 . . . cord-009571-mygj2nd4 966 1 Patients patient NNS cord-009571-mygj2nd4 966 2 with with IN cord-009571-mygj2nd4 966 3 high high JJ cord-009571-mygj2nd4 966 4 C4 c4 NN cord-009571-mygj2nd4 966 5 FCRs fcr NNS cord-009571-mygj2nd4 966 6 had have VBD cord-009571-mygj2nd4 966 7 higher high JJR cord-009571-mygj2nd4 966 8 total total JJ cord-009571-mygj2nd4 966 9 joint joint JJ cord-009571-mygj2nd4 966 10 counts count NNS cord-009571-mygj2nd4 966 11 and and CC cord-009571-mygj2nd4 966 12 a a DT cord-009571-mygj2nd4 966 13 greater great JJR cord-009571-mygj2nd4 966 14 number number NN cord-009571-mygj2nd4 966 15 of of IN cord-009571-mygj2nd4 966 16 manifestations manifestation NNS cord-009571-mygj2nd4 966 17 of of IN cord-009571-mygj2nd4 966 18 extraarticular extraarticular JJ cord-009571-mygj2nd4 966 19 disease disease NN cord-009571-mygj2nd4 966 20 . . . cord-009571-mygj2nd4 967 1 C4 C4 NNP cord-009571-mygj2nd4 967 2 and and CC cord-009571-mygj2nd4 967 3 FB FB NNP cord-009571-mygj2nd4 967 4 FCRs FCRs NNP cord-009571-mygj2nd4 967 5 did do VBD cord-009571-mygj2nd4 967 6 not not RB cord-009571-mygj2nd4 967 7 correlate correlate VB cord-009571-mygj2nd4 967 8 with with IN cord-009571-mygj2nd4 967 9 circulating circulate VBG cord-009571-mygj2nd4 967 10 immune immune JJ cord-009571-mygj2nd4 967 11 complexes complex NNS cord-009571-mygj2nd4 967 12 by by IN cord-009571-mygj2nd4 967 13 the the DT cord-009571-mygj2nd4 967 14 Raji Raji NNP cord-009571-mygj2nd4 967 15 cell cell NN cord-009571-mygj2nd4 967 16 assay assay NN cord-009571-mygj2nd4 967 17 or or CC cord-009571-mygj2nd4 967 18 with with IN cord-009571-mygj2nd4 967 19 the the DT cord-009571-mygj2nd4 967 20 sedimentation sedimentation NN cord-009571-mygj2nd4 967 21 rate rate NN cord-009571-mygj2nd4 967 22 . . . cord-009571-mygj2nd4 968 1 The the DT cord-009571-mygj2nd4 968 2 results result NNS cord-009571-mygj2nd4 968 3 suggest suggest VBP cord-009571-mygj2nd4 968 4 that that IN cord-009571-mygj2nd4 968 5 complement complement JJ cord-009571-mygj2nd4 968 6 activation activation NN cord-009571-mygj2nd4 968 7 in in IN cord-009571-mygj2nd4 968 8 RA RA NNP cord-009571-mygj2nd4 968 9 occurs occur VBZ cord-009571-mygj2nd4 968 10 primarily primarily RB cord-009571-mygj2nd4 968 11 through through IN cord-009571-mygj2nd4 968 12 the the DT cord-009571-mygj2nd4 968 13 classical classical JJ cord-009571-mygj2nd4 968 14 pathway pathway NN cord-009571-mygj2nd4 968 15 and and CC cord-009571-mygj2nd4 968 16 in in IN cord-009571-mygj2nd4 968 17 the the DT cord-009571-mygj2nd4 968 18 extravascular extravascular NNP cord-009571-mygj2nd4 968 19 compartment compartment NNP cord-009571-mygj2nd4 968 20 , , , cord-009571-mygj2nd4 968 21 probably probably RB cord-009571-mygj2nd4 968 22 principally principally RB cord-009571-mygj2nd4 968 23 by by IN cord-009571-mygj2nd4 968 24 immune immune JJ cord-009571-mygj2nd4 968 25 complexes complex NNS cord-009571-mygj2nd4 968 26 not not RB cord-009571-mygj2nd4 968 27 detected detect VBN cord-009571-mygj2nd4 968 28 by by IN cord-009571-mygj2nd4 968 29 the the DT cord-009571-mygj2nd4 968 30 Raji Raji NNP cord-009571-mygj2nd4 968 31 cell cell NN cord-009571-mygj2nd4 968 32 assay assay NN cord-009571-mygj2nd4 968 33 , , , cord-009571-mygj2nd4 968 34 and and CC cord-009571-mygj2nd4 968 35 with with IN cord-009571-mygj2nd4 968 36 participation participation NN cord-009571-mygj2nd4 968 37 of of IN cord-009571-mygj2nd4 968 38 the the DT cord-009571-mygj2nd4 968 39 alternative alternative JJ cord-009571-mygj2nd4 968 40 pathway pathway NN cord-009571-mygj2nd4 968 41 in in IN cord-009571-mygj2nd4 968 42 some some DT cord-009571-mygj2nd4 968 43 of of IN cord-009571-mygj2nd4 968 44 the the DT cord-009571-mygj2nd4 968 45 patients patient NNS cord-009571-mygj2nd4 968 46 . . . cord-009571-mygj2nd4 969 1 Studies study NNS cord-009571-mygj2nd4 969 2 from from IN cord-009571-mygj2nd4 969 3 this this DT cord-009571-mygj2nd4 969 4 laboratory laboratory NN cord-009571-mygj2nd4 969 5 have have VBP cord-009571-mygj2nd4 969 6 demonstrated demonstrate VBN cord-009571-mygj2nd4 969 7 that that IN cord-009571-mygj2nd4 969 8 the the DT cord-009571-mygj2nd4 969 9 PHA PHA NNP cord-009571-mygj2nd4 969 10 and and CC cord-009571-mygj2nd4 969 11 Con Con NNP cord-009571-mygj2nd4 969 12 - - HYPH cord-009571-mygj2nd4 969 13 A A NNP cord-009571-mygj2nd4 969 14 responses response NNS cord-009571-mygj2nd4 969 15 of of IN cord-009571-mygj2nd4 969 16 splenic splenic JJ cord-009571-mygj2nd4 969 17 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 969 18 from from IN cord-009571-mygj2nd4 969 19 rats rat NNS cord-009571-mygj2nd4 969 20 with with IN cord-009571-mygj2nd4 969 21 adjuvant adjuvant NN cord-009571-mygj2nd4 969 22 - - HYPH cord-009571-mygj2nd4 969 23 induced induce VBN cord-009571-mygj2nd4 969 24 disease disease NN cord-009571-mygj2nd4 969 25 are be VBP cord-009571-mygj2nd4 969 26 diminished diminish VBN cord-009571-mygj2nd4 969 27 . . . cord-009571-mygj2nd4 970 1 These these DT cord-009571-mygj2nd4 970 2 diminished diminish VBN cord-009571-mygj2nd4 970 3 responses response NNS cord-009571-mygj2nd4 970 4 return return VBP cord-009571-mygj2nd4 970 5 to to IN cord-009571-mygj2nd4 970 6 normal normal JJ cord-009571-mygj2nd4 970 7 with with IN cord-009571-mygj2nd4 970 8 spontaneous spontaneous JJ cord-009571-mygj2nd4 970 9 , , , cord-009571-mygj2nd4 970 10 corticosteroid corticosteroid JJ cord-009571-mygj2nd4 970 11 ( ( -LRB- cord-009571-mygj2nd4 970 12 CS CS NNP cord-009571-mygj2nd4 970 13 ) ) -RRB- cord-009571-mygj2nd4 970 14 , , , cord-009571-mygj2nd4 970 15 or or CC cord-009571-mygj2nd4 970 16 methotrexate methotrexate NNP cord-009571-mygj2nd4 970 17 ( ( -LRB- cord-009571-mygj2nd4 970 18 MTXtinduced mtxtinduced JJ cord-009571-mygj2nd4 970 19 remissions remission NNS cord-009571-mygj2nd4 970 20 . . . cord-009571-mygj2nd4 971 1 The the DT cord-009571-mygj2nd4 971 2 diminished diminished JJ cord-009571-mygj2nd4 971 3 PHA PHA NNP cord-009571-mygj2nd4 971 4 and and CC cord-009571-mygj2nd4 971 5 Con con NN cord-009571-mygj2nd4 971 6 - - HYPH cord-009571-mygj2nd4 971 7 A a DT cord-009571-mygj2nd4 971 8 responses response NNS cord-009571-mygj2nd4 971 9 are be VBP cord-009571-mygj2nd4 971 10 due due JJ cord-009571-mygj2nd4 971 11 to to IN cord-009571-mygj2nd4 971 12 two two CD cord-009571-mygj2nd4 971 13 types type NNS cord-009571-mygj2nd4 971 14 of of IN cord-009571-mygj2nd4 971 15 suppressor suppressor NN cord-009571-mygj2nd4 971 16 cell cell NN cord-009571-mygj2nd4 971 17 : : : cord-009571-mygj2nd4 971 18 one one NN cord-009571-mygj2nd4 971 19 which which WDT cord-009571-mygj2nd4 971 20 adheres adhere VBZ cord-009571-mygj2nd4 971 21 to to IN cord-009571-mygj2nd4 971 22 plastic plastic NN cord-009571-mygj2nd4 971 23 ar ar NNP cord-009571-mygj2nd4 971 24 glass glass NN cord-009571-mygj2nd4 971 25 , , , cord-009571-mygj2nd4 971 26 and and CC cord-009571-mygj2nd4 971 27 another another DT cord-009571-mygj2nd4 971 28 which which WDT cord-009571-mygj2nd4 971 29 adheres adhere VBZ cord-009571-mygj2nd4 971 30 only only RB cord-009571-mygj2nd4 971 31 to to IN cord-009571-mygj2nd4 971 32 glass glass VB cord-009571-mygj2nd4 971 33 . . . cord-009571-mygj2nd4 972 1 The the DT cord-009571-mygj2nd4 972 2 latter latter JJ cord-009571-mygj2nd4 972 3 cell cell NN cord-009571-mygj2nd4 972 4 , , , cord-009571-mygj2nd4 972 5 which which WDT cord-009571-mygj2nd4 972 6 accounts account VBZ cord-009571-mygj2nd4 972 7 for for IN cord-009571-mygj2nd4 972 8 the the DT cord-009571-mygj2nd4 972 9 bulk bulk NN cord-009571-mygj2nd4 972 10 of of IN cord-009571-mygj2nd4 972 11 the the DT cord-009571-mygj2nd4 972 12 suppression suppression NN cord-009571-mygj2nd4 972 13 , , , cord-009571-mygj2nd4 972 14 is be VBZ cord-009571-mygj2nd4 972 15 more more RBR cord-009571-mygj2nd4 972 16 sensitive sensitive JJ cord-009571-mygj2nd4 972 17 to to IN cord-009571-mygj2nd4 972 18 the the DT cord-009571-mygj2nd4 972 19 inhibitory inhibitory JJ cord-009571-mygj2nd4 972 20 effects effect NNS cord-009571-mygj2nd4 972 21 of of IN cord-009571-mygj2nd4 972 22 CS CS NNP cord-009571-mygj2nd4 972 23 and and CC cord-009571-mygj2nd4 972 24 MTX MTX NNP cord-009571-mygj2nd4 972 25 in in IN cord-009571-mygj2nd4 972 26 vitro vitro FW cord-009571-mygj2nd4 972 27 than than IN cord-009571-mygj2nd4 972 28 are be VBP cord-009571-mygj2nd4 972 29 the the DT cord-009571-mygj2nd4 972 30 mitogen mitogen NN cord-009571-mygj2nd4 972 31 - - HYPH cord-009571-mygj2nd4 972 32 responsive responsive JJ cord-009571-mygj2nd4 972 33 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 972 34 . . . cord-009571-mygj2nd4 973 1 Virazole Virazole NNP cord-009571-mygj2nd4 973 2 ( ( -LRB- cord-009571-mygj2nd4 973 3 VZL VZL NNP cord-009571-mygj2nd4 973 4 ) ) -RRB- cord-009571-mygj2nd4 973 5 , , , cord-009571-mygj2nd4 973 6 a a DT cord-009571-mygj2nd4 973 7 synthetic synthetic JJ cord-009571-mygj2nd4 973 8 nucleoside nucleoside NN cord-009571-mygj2nd4 973 9 , , , cord-009571-mygj2nd4 973 10 is be VBZ cord-009571-mygj2nd4 973 11 a a DT cord-009571-mygj2nd4 973 12 noninterferon noninterferon NN cord-009571-mygj2nd4 973 13 inducing induce VBG cord-009571-mygj2nd4 973 14 antiviral antiviral JJ cord-009571-mygj2nd4 973 15 agent agent NN cord-009571-mygj2nd4 973 16 which which WDT cord-009571-mygj2nd4 973 17 inhibits inhibit VBZ cord-009571-mygj2nd4 973 18 AID aid NN cord-009571-mygj2nd4 973 19 . . . cord-009571-mygj2nd4 974 1 Four four CD cord-009571-mygj2nd4 974 2 groups group NNS cord-009571-mygj2nd4 974 3 of of IN cord-009571-mygj2nd4 974 4 highly highly RB cord-009571-mygj2nd4 974 5 inbred inbred JJ cord-009571-mygj2nd4 974 6 Fisher Fisher NNP cord-009571-mygj2nd4 974 7 rats rat NNS cord-009571-mygj2nd4 974 8 were be VBD cord-009571-mygj2nd4 974 9 studied study VBN cord-009571-mygj2nd4 974 10 as as IN cord-009571-mygj2nd4 974 11 follows follow VBZ cord-009571-mygj2nd4 974 12 : : : cord-009571-mygj2nd4 974 13 1 1 LS cord-009571-mygj2nd4 974 14 ) ) -RRB- cord-009571-mygj2nd4 974 15 untreated untreated JJ cord-009571-mygj2nd4 974 16 rats rat NNS cord-009571-mygj2nd4 974 17 ; ; : cord-009571-mygj2nd4 974 18 2 2 CD cord-009571-mygj2nd4 974 19 ) ) -RRB- cord-009571-mygj2nd4 974 20 rats rat NNS cord-009571-mygj2nd4 974 21 treated treat VBN cord-009571-mygj2nd4 974 22 with with IN cord-009571-mygj2nd4 974 23 200 200 CD cord-009571-mygj2nd4 974 24 mg mg NN cord-009571-mygj2nd4 974 25 of of IN cord-009571-mygj2nd4 974 26 VZL VZL NNP cord-009571-mygj2nd4 974 27 given give VBN cord-009571-mygj2nd4 974 28 7 7 CD cord-009571-mygj2nd4 974 29 days day NNS cord-009571-mygj2nd4 974 30 prior prior RB cord-009571-mygj2nd4 974 31 to to IN cord-009571-mygj2nd4 974 32 sacrifice sacrifice NN cord-009571-mygj2nd4 974 33 ; ; : cord-009571-mygj2nd4 974 34 3 3 LS cord-009571-mygj2nd4 974 35 ) ) -RRB- cord-009571-mygj2nd4 974 36 rats rat NNS cord-009571-mygj2nd4 974 37 treated treat VBN cord-009571-mygj2nd4 974 38 with with IN cord-009571-mygj2nd4 974 39 Freund Freund NNP cord-009571-mygj2nd4 974 40 's 's POS cord-009571-mygj2nd4 974 41 adjuvant adjuvant NN cord-009571-mygj2nd4 974 42 given give VBN cord-009571-mygj2nd4 974 43 14 14 CD cord-009571-mygj2nd4 974 44 days day NNS cord-009571-mygj2nd4 974 45 prior prior RB cord-009571-mygj2nd4 974 46 to to IN cord-009571-mygj2nd4 974 47 sacrifice sacrifice NN cord-009571-mygj2nd4 974 48 ; ; : cord-009571-mygj2nd4 974 49 4 4 LS cord-009571-mygj2nd4 974 50 ) ) -RRB- cord-009571-mygj2nd4 974 51 rats rat NNS cord-009571-mygj2nd4 974 52 treated treat VBN cord-009571-mygj2nd4 974 53 with with IN cord-009571-mygj2nd4 974 54 Freund Freund NNP cord-009571-mygj2nd4 974 55 's 's POS cord-009571-mygj2nd4 974 56 adjuvant adjuvant NN cord-009571-mygj2nd4 974 57 followed follow VBN cord-009571-mygj2nd4 974 58 by by IN cord-009571-mygj2nd4 974 59 VZL vzl NN cord-009571-mygj2nd4 974 60 7 7 CD cord-009571-mygj2nd4 974 61 days day NNS cord-009571-mygj2nd4 974 62 later later RB cord-009571-mygj2nd4 974 63 . . . cord-009571-mygj2nd4 975 1 Whole whole JJ cord-009571-mygj2nd4 975 2 spleen spleen NN cord-009571-mygj2nd4 975 3 cell cell NN cord-009571-mygj2nd4 975 4 suspensions suspension NNS cord-009571-mygj2nd4 975 5 were be VBD cord-009571-mygj2nd4 975 6 studied study VBN cord-009571-mygj2nd4 975 7 , , , cord-009571-mygj2nd4 975 8 as as RB cord-009571-mygj2nd4 975 9 well well RB cord-009571-mygj2nd4 975 10 as as IN cord-009571-mygj2nd4 975 11 suspensions suspension NNS cord-009571-mygj2nd4 975 12 after after IN cord-009571-mygj2nd4 975 13 removal removal NN cord-009571-mygj2nd4 975 14 of of IN cord-009571-mygj2nd4 975 15 plastic plastic NN cord-009571-mygj2nd4 975 16 - - HYPH cord-009571-mygj2nd4 975 17 adherent adherent JJ cord-009571-mygj2nd4 975 18 cells cell NNS cord-009571-mygj2nd4 975 19 by by IN cord-009571-mygj2nd4 975 20 incubation incubation NN cord-009571-mygj2nd4 975 21 in in IN cord-009571-mygj2nd4 975 22 petri petri JJ cord-009571-mygj2nd4 975 23 dishes dish NNS cord-009571-mygj2nd4 975 24 or or CC cord-009571-mygj2nd4 975 25 after after IN cord-009571-mygj2nd4 975 26 removal removal NN cord-009571-mygj2nd4 975 27 of of IN cord-009571-mygj2nd4 975 28 glass glass NN cord-009571-mygj2nd4 975 29 - - HYPH cord-009571-mygj2nd4 975 30 adherent adherent JJ cord-009571-mygj2nd4 975 31 cells cell NNS cord-009571-mygj2nd4 975 32 on on IN cord-009571-mygj2nd4 975 33 columns column NNS cord-009571-mygj2nd4 975 34 of of IN cord-009571-mygj2nd4 975 35 glass glass NN cord-009571-mygj2nd4 975 36 wool wool NN cord-009571-mygj2nd4 975 37 . . . cord-009571-mygj2nd4 976 1 Each each DT cord-009571-mygj2nd4 976 2 of of IN cord-009571-mygj2nd4 976 3 these these DT cord-009571-mygj2nd4 976 4 three three CD cord-009571-mygj2nd4 976 5 types type NNS cord-009571-mygj2nd4 976 6 of of IN cord-009571-mygj2nd4 976 7 suspension suspension NN cord-009571-mygj2nd4 976 8 was be VBD cord-009571-mygj2nd4 976 9 also also RB cord-009571-mygj2nd4 976 10 incubated incubate VBN cord-009571-mygj2nd4 976 11 with with IN cord-009571-mygj2nd4 976 12 a a DT cord-009571-mygj2nd4 976 13 range range NN cord-009571-mygj2nd4 976 14 of of IN cord-009571-mygj2nd4 976 15 concentrations concentration NNS cord-009571-mygj2nd4 976 16 of of IN cord-009571-mygj2nd4 976 17 VZL vzl NN cord-009571-mygj2nd4 976 18 and and CC cord-009571-mygj2nd4 976 19 with with IN cord-009571-mygj2nd4 976 20 either either CC cord-009571-mygj2nd4 976 21 PHA PHA NNP cord-009571-mygj2nd4 976 22 or or CC cord-009571-mygj2nd4 976 23 Con con NN cord-009571-mygj2nd4 976 24 A. a. NN cord-009571-mygj2nd4 976 25 aH aH NNP cord-009571-mygj2nd4 976 26 - - HYPH cord-009571-mygj2nd4 976 27 rdR rdr NN cord-009571-mygj2nd4 976 28 incorporation incorporation NN cord-009571-mygj2nd4 976 29 into into IN cord-009571-mygj2nd4 976 30 nucleic nucleic JJ cord-009571-mygj2nd4 976 31 acid acid NN cord-009571-mygj2nd4 976 32 was be VBD cord-009571-mygj2nd4 976 33 determined determine VBN cord-009571-mygj2nd4 976 34 at at IN cord-009571-mygj2nd4 976 35 72 72 CD cord-009571-mygj2nd4 976 36 hours hour NNS cord-009571-mygj2nd4 976 37 . . . cord-009571-mygj2nd4 977 1 Spleen spleen NN cord-009571-mygj2nd4 977 2 cells cell NNS cord-009571-mygj2nd4 977 3 from from IN cord-009571-mygj2nd4 977 4 untreated untreated JJ cord-009571-mygj2nd4 977 5 rats rat NNS cord-009571-mygj2nd4 977 6 , , , cord-009571-mygj2nd4 977 7 rats rat NNS cord-009571-mygj2nd4 977 8 given give VBN cord-009571-mygj2nd4 977 9 200 200 CD cord-009571-mygj2nd4 977 10 mg mg NN cord-009571-mygj2nd4 977 11 of of IN cord-009571-mygj2nd4 977 12 VZL vzl NN cord-009571-mygj2nd4 977 13 7 7 CD cord-009571-mygj2nd4 977 14 days day NNS cord-009571-mygj2nd4 977 15 prior prior RB cord-009571-mygj2nd4 977 16 to to IN cord-009571-mygj2nd4 977 17 sacrifice sacrifice NN cord-009571-mygj2nd4 977 18 , , , cord-009571-mygj2nd4 977 19 and and CC cord-009571-mygj2nd4 977 20 adjuvant adjuvant NN cord-009571-mygj2nd4 977 21 - - HYPH cord-009571-mygj2nd4 977 22 treated treat VBN cord-009571-mygj2nd4 977 23 rats rat NNS cord-009571-mygj2nd4 977 24 given give VBN cord-009571-mygj2nd4 977 25 VZL vzl NN cord-009571-mygj2nd4 977 26 had have VBD cord-009571-mygj2nd4 977 27 normal normal JJ cord-009571-mygj2nd4 977 28 PHA PHA NNP cord-009571-mygj2nd4 977 29 and and CC cord-009571-mygj2nd4 977 30 Con Con NNP cord-009571-mygj2nd4 977 31 A A NNP cord-009571-mygj2nd4 977 32 responses response NNS cord-009571-mygj2nd4 977 33 . . . cord-009571-mygj2nd4 978 1 The the DT cord-009571-mygj2nd4 978 2 spleen spleen NN cord-009571-mygj2nd4 978 3 cells cell NNS cord-009571-mygj2nd4 978 4 from from IN cord-009571-mygj2nd4 978 5 rats rat NNS cord-009571-mygj2nd4 978 6 given give VBN cord-009571-mygj2nd4 978 7 adjuvant adjuvant NN cord-009571-mygj2nd4 978 8 alone alone RB cord-009571-mygj2nd4 978 9 had have VBD cord-009571-mygj2nd4 978 10 markedly markedly RB cord-009571-mygj2nd4 978 11 diminished diminish VBN cord-009571-mygj2nd4 978 12 PHA PHA NNP cord-009571-mygj2nd4 978 13 and and CC cord-009571-mygj2nd4 978 14 Con con NN cord-009571-mygj2nd4 978 15 - - HYPH cord-009571-mygj2nd4 978 16 A A NNP cord-009571-mygj2nd4 978 17 responses response NNS cord-009571-mygj2nd4 978 18 due due JJ cord-009571-mygj2nd4 978 19 to to IN cord-009571-mygj2nd4 978 20 the the DT cord-009571-mygj2nd4 978 21 two two CD cord-009571-mygj2nd4 978 22 types type NNS cord-009571-mygj2nd4 978 23 of of IN cord-009571-mygj2nd4 978 24 supprcssbr supprcssbr NN cord-009571-mygj2nd4 978 25 cells cell NNS cord-009571-mygj2nd4 978 26 , , , cord-009571-mygj2nd4 978 27 both both DT cord-009571-mygj2nd4 978 28 of of IN cord-009571-mygj2nd4 978 29 which which WDT cord-009571-mygj2nd4 978 30 were be VBD cord-009571-mygj2nd4 978 31 more more RBR cord-009571-mygj2nd4 978 32 sensitive sensitive JJ cord-009571-mygj2nd4 978 33 to to IN cord-009571-mygj2nd4 978 34 VZL vzl NN cord-009571-mygj2nd4 978 35 in in IN cord-009571-mygj2nd4 978 36 vitro vitro FW cord-009571-mygj2nd4 978 37 than than IN cord-009571-mygj2nd4 978 38 were be VBD cord-009571-mygj2nd4 978 39 the the DT cord-009571-mygj2nd4 978 40 mitogen mitogen NN cord-009571-mygj2nd4 978 41 responsive responsive JJ cord-009571-mygj2nd4 978 42 cells cell NNS cord-009571-mygj2nd4 978 43 . . . cord-009571-mygj2nd4 979 1 This this DT cord-009571-mygj2nd4 979 2 preferential preferential JJ cord-009571-mygj2nd4 979 3 sensitivity sensitivity NN cord-009571-mygj2nd4 979 4 of of IN cord-009571-mygj2nd4 979 5 suppressor suppressor NN cord-009571-mygj2nd4 979 6 cells cell NNS cord-009571-mygj2nd4 979 7 to to IN cord-009571-mygj2nd4 979 8 VZL vzl NN cord-009571-mygj2nd4 979 9 was be VBD cord-009571-mygj2nd4 979 10 greater great JJR cord-009571-mygj2nd4 979 11 than than IN cord-009571-mygj2nd4 979 12 that that DT cord-009571-mygj2nd4 979 13 noted note VBN cord-009571-mygj2nd4 979 14 with with IN cord-009571-mygj2nd4 979 15 CS CS NNP cord-009571-mygj2nd4 979 16 or or CC cord-009571-mygj2nd4 979 17 MTX MTX NNP cord-009571-mygj2nd4 979 18 . . . cord-009571-mygj2nd4 980 1 Two two CD cord-009571-mygj2nd4 980 2 possible possible JJ cord-009571-mygj2nd4 980 3 interpretations interpretation NNS cord-009571-mygj2nd4 980 4 are be VBP cord-009571-mygj2nd4 980 5 : : : cord-009571-mygj2nd4 981 1 1 1 LS cord-009571-mygj2nd4 981 2 ) ) -RRB- cord-009571-mygj2nd4 981 3 VZL VZL NNP cord-009571-mygj2nd4 981 4 has have VBZ cord-009571-mygj2nd4 981 5 a a DT cord-009571-mygj2nd4 981 6 more more RBR cord-009571-mygj2nd4 981 7 specific specific JJ cord-009571-mygj2nd4 981 8 immunosuppressive immunosuppressive JJ cord-009571-mygj2nd4 981 9 effect effect NN cord-009571-mygj2nd4 981 10 on on IN cord-009571-mygj2nd4 981 11 suppressor suppressor NN cord-009571-mygj2nd4 981 12 cells cell NNS cord-009571-mygj2nd4 981 13 than than IN cord-009571-mygj2nd4 981 14 CS CS NNP cord-009571-mygj2nd4 981 15 or or CC cord-009571-mygj2nd4 981 16 MTX MTX NNP cord-009571-mygj2nd4 981 17 ; ; : cord-009571-mygj2nd4 981 18 2 2 CD cord-009571-mygj2nd4 981 19 ) ) -RRB- cord-009571-mygj2nd4 981 20 suppressor suppressor NN cord-009571-mygj2nd4 981 21 cell cell NN cord-009571-mygj2nd4 981 22 function function NN cord-009571-mygj2nd4 981 23 is be VBZ cord-009571-mygj2nd4 981 24 due due JJ cord-009571-mygj2nd4 981 25 to to IN cord-009571-mygj2nd4 981 26 a a DT cord-009571-mygj2nd4 981 27 virus virus NN cord-009571-mygj2nd4 981 28 which which WDT cord-009571-mygj2nd4 981 29 is be VBZ cord-009571-mygj2nd4 981 30 inhibited inhibit VBN cord-009571-mygj2nd4 981 31 by by IN cord-009571-mygj2nd4 981 32 VZL vzl NN cord-009571-mygj2nd4 981 33 . . . cord-009571-mygj2nd4 982 1 Twenty twenty CD cord-009571-mygj2nd4 982 2 - - HYPH cord-009571-mygj2nd4 982 3 four four CD cord-009571-mygj2nd4 982 4 cerebrospinal cerebrospinal JJ cord-009571-mygj2nd4 982 5 fluid fluid NN cord-009571-mygj2nd4 982 6 ( ( -LRB- cord-009571-mygj2nd4 982 7 CSF CSF NNP cord-009571-mygj2nd4 982 8 ) ) -RRB- cord-009571-mygj2nd4 982 9 samples sample VBZ cord-009571-mygj2nd4 982 10 from from IN cord-009571-mygj2nd4 982 11 16 16 CD cord-009571-mygj2nd4 982 12 patients patient NNS cord-009571-mygj2nd4 982 13 with with IN cord-009571-mygj2nd4 982 14 systemic systemic JJ cord-009571-mygj2nd4 982 15 lupus lupus NN cord-009571-mygj2nd4 982 16 erythematosus erythematosus NN cord-009571-mygj2nd4 982 17 ( ( -LRB- cord-009571-mygj2nd4 982 18 SLE SLE NNP cord-009571-mygj2nd4 982 19 ) ) -RRB- cord-009571-mygj2nd4 982 20 were be VBD cord-009571-mygj2nd4 982 21 evaluated evaluate VBN cord-009571-mygj2nd4 982 22 for for IN cord-009571-mygj2nd4 982 23 cyclic cyclic JJ cord-009571-mygj2nd4 982 24 - - HYPH cord-009571-mygj2nd4 982 25 GMP GMP NNP cord-009571-mygj2nd4 982 26 ( ( -LRB- cord-009571-mygj2nd4 982 27 C C NNP cord-009571-mygj2nd4 982 28 - - HYPH cord-009571-mygj2nd4 982 29 GMP GMP NNP cord-009571-mygj2nd4 982 30 ) ) -RRB- cord-009571-mygj2nd4 982 31 concentration concentration NN cord-009571-mygj2nd4 982 32 by by IN cord-009571-mygj2nd4 982 33 radioimmunoassay radioimmunoassay JJ cord-009571-mygj2nd4 982 34 . . . cord-009571-mygj2nd4 983 1 For for IN cord-009571-mygj2nd4 983 2 comparison comparison NN cord-009571-mygj2nd4 983 3 studies study NNS cord-009571-mygj2nd4 983 4 , , , cord-009571-mygj2nd4 983 5 the the DT cord-009571-mygj2nd4 983 6 patients patient NNS cord-009571-mygj2nd4 983 7 were be VBD cord-009571-mygj2nd4 983 8 divided divide VBN cord-009571-mygj2nd4 983 9 into into IN cord-009571-mygj2nd4 983 10 three three CD cord-009571-mygj2nd4 983 11 groups group NNS cord-009571-mygj2nd4 983 12 based base VBN cord-009571-mygj2nd4 983 13 on on IN cord-009571-mygj2nd4 983 14 their -PRON- PRP$ cord-009571-mygj2nd4 983 15 clinical clinical JJ cord-009571-mygj2nd4 983 16 status status NN cord-009571-mygj2nd4 983 17 at at IN cord-009571-mygj2nd4 983 18 the the DT cord-009571-mygj2nd4 983 19 time time NN cord-009571-mygj2nd4 983 20 of of IN cord-009571-mygj2nd4 983 21 each each DT cord-009571-mygj2nd4 983 22 lumbar lumbar NN cord-009571-mygj2nd4 983 23 puncture puncture NN cord-009571-mygj2nd4 983 24 : : : cord-009571-mygj2nd4 983 25 those those DT cord-009571-mygj2nd4 983 26 with with IN cord-009571-mygj2nd4 983 27 1 1 CD cord-009571-mygj2nd4 983 28 ) ) -RRB- cord-009571-mygj2nd4 983 29 active active JJ cord-009571-mygj2nd4 983 30 neurologic neurologic JJ cord-009571-mygj2nd4 983 31 and and CC cord-009571-mygj2nd4 983 32 psychologic psychologic JJ cord-009571-mygj2nd4 983 33 abnormalities abnormality NNS cord-009571-mygj2nd4 983 34 ( ( -LRB- cord-009571-mygj2nd4 983 35 group group NN cord-009571-mygj2nd4 983 36 I I NNP cord-009571-mygj2nd4 983 37 ) ) -RRB- cord-009571-mygj2nd4 983 38 , , , cord-009571-mygj2nd4 983 39 2 2 CD cord-009571-mygj2nd4 983 40 ) ) -RRB- cord-009571-mygj2nd4 983 41 active active JJ cord-009571-mygj2nd4 983 42 neurologic neurologic JJ cord-009571-mygj2nd4 983 43 abnormalities abnormality NNS cord-009571-mygj2nd4 983 44 only only RB cord-009571-mygj2nd4 983 45 ( ( -LRB- cord-009571-mygj2nd4 983 46 group group NN cord-009571-mygj2nd4 983 47 II II NNP cord-009571-mygj2nd4 983 48 ) ) -RRB- cord-009571-mygj2nd4 983 49 , , , cord-009571-mygj2nd4 983 50 and and CC cord-009571-mygj2nd4 983 51 3 3 LS cord-009571-mygj2nd4 983 52 ) ) -RRB- cord-009571-mygj2nd4 983 53 psychologic psychologic JJ cord-009571-mygj2nd4 983 54 abnormalities abnormality NNS cord-009571-mygj2nd4 983 55 only only RB cord-009571-mygj2nd4 983 56 ( ( -LRB- cord-009571-mygj2nd4 983 57 group group NN cord-009571-mygj2nd4 983 58 111 111 CD cord-009571-mygj2nd4 983 59 ) ) -RRB- cord-009571-mygj2nd4 983 60 . . . cord-009571-mygj2nd4 984 1 Groups group NNS cord-009571-mygj2nd4 984 2 I -PRON- PRP cord-009571-mygj2nd4 984 3 and and CC cord-009571-mygj2nd4 984 4 I1 i1 NN cord-009571-mygj2nd4 984 5 had have VBD cord-009571-mygj2nd4 984 6 mean mean JJ cord-009571-mygj2nd4 984 7 CSF CSF NNP cord-009571-mygj2nd4 984 8 C C NNP cord-009571-mygj2nd4 984 9 - - HYPH cord-009571-mygj2nd4 984 10 GMP GMP NNP cord-009571-mygj2nd4 984 11 values value NNS cord-009571-mygj2nd4 984 12 of of IN cord-009571-mygj2nd4 984 13 3.2 3.2 CD cord-009571-mygj2nd4 984 14 nM nm NN cord-009571-mygj2nd4 984 15 f f NN cord-009571-mygj2nd4 984 16 0.64 0.64 CD cord-009571-mygj2nd4 984 17 ( ( -LRB- cord-009571-mygj2nd4 984 18 SE SE NNP cord-009571-mygj2nd4 984 19 ) ) -RRB- cord-009571-mygj2nd4 984 20 and and CC cord-009571-mygj2nd4 984 21 4.1 4.1 CD cord-009571-mygj2nd4 984 22 nM nm NN cord-009571-mygj2nd4 984 23 f f NN cord-009571-mygj2nd4 984 24 0.10 0.10 CD cord-009571-mygj2nd4 984 25 respectively respectively RB cord-009571-mygj2nd4 984 26 , , , cord-009571-mygj2nd4 984 27 which which WDT cord-009571-mygj2nd4 984 28 were be VBD cord-009571-mygj2nd4 984 29 both both DT cord-009571-mygj2nd4 984 30 significantly significantly RB cord-009571-mygj2nd4 984 31 higher high JJR cord-009571-mygj2nd4 984 32 than than IN cord-009571-mygj2nd4 984 33 the the DT cord-009571-mygj2nd4 984 34 mean mean NN cord-009571-mygj2nd4 984 35 for for IN cord-009571-mygj2nd4 984 36 group group NN cord-009571-mygj2nd4 984 37 I11 I11 NNP cord-009571-mygj2nd4 984 38 ( ( -LRB- cord-009571-mygj2nd4 984 39 1.2 1.2 CD cord-009571-mygj2nd4 984 40 nM nm NN cord-009571-mygj2nd4 984 41 f f NN cord-009571-mygj2nd4 984 42 0.43 0.43 CD cord-009571-mygj2nd4 984 43 ) ) -RRB- cord-009571-mygj2nd4 985 1 ( ( -LRB- cord-009571-mygj2nd4 985 2 P p NN cord-009571-mygj2nd4 985 3 < < XX cord-009571-mygj2nd4 985 4 0.05 0.05 CD cord-009571-mygj2nd4 985 5 ) ) -RRB- cord-009571-mygj2nd4 985 6 as as RB cord-009571-mygj2nd4 985 7 well well RB cord-009571-mygj2nd4 985 8 as as IN cord-009571-mygj2nd4 985 9 for for IN cord-009571-mygj2nd4 985 10 the the DT cord-009571-mygj2nd4 985 11 mean mean NN cord-009571-mygj2nd4 985 12 of of IN cord-009571-mygj2nd4 985 13 a a DT cord-009571-mygj2nd4 985 14 previously previously RB cord-009571-mygj2nd4 985 15 studied study VBN cord-009571-mygj2nd4 985 16 group group NN cord-009571-mygj2nd4 985 17 of of IN cord-009571-mygj2nd4 985 18 patients patient NNS cord-009571-mygj2nd4 985 19 with with IN cord-009571-mygj2nd4 985 20 lumbosacral lumbosacral JJ cord-009571-mygj2nd4 985 21 pain pain NN cord-009571-mygj2nd4 985 22 syndromes syndrome NNS cord-009571-mygj2nd4 985 23 ( ( -LRB- cord-009571-mygj2nd4 985 24 0.68 0.68 CD cord-009571-mygj2nd4 985 25 nM nm NN cord-009571-mygj2nd4 985 26 f f NN cord-009571-mygj2nd4 985 27 0.14 0.14 CD cord-009571-mygj2nd4 985 28 ) ) -RRB- cord-009571-mygj2nd4 986 1 ( ( -LRB- cord-009571-mygj2nd4 986 2 P p NN cord-009571-mygj2nd4 986 3 < < XX cord-009571-mygj2nd4 986 4 0.001 0.001 CD cord-009571-mygj2nd4 986 5 ) ) -RRB- cord-009571-mygj2nd4 986 6 . . . cord-009571-mygj2nd4 987 1 Other other JJ cord-009571-mygj2nd4 987 2 CSF CSF NNP cord-009571-mygj2nd4 987 3 findings finding NNS cord-009571-mygj2nd4 987 4 did do VBD cord-009571-mygj2nd4 987 5 not not RB cord-009571-mygj2nd4 987 6 display display VB cord-009571-mygj2nd4 987 7 this this DT cord-009571-mygj2nd4 987 8 close close JJ cord-009571-mygj2nd4 987 9 correlation correlation NN cord-009571-mygj2nd4 987 10 with with IN cord-009571-mygj2nd4 987 11 activity activity NN cord-009571-mygj2nd4 987 12 of of IN cord-009571-mygj2nd4 987 13 neurologic neurologic JJ cord-009571-mygj2nd4 987 14 disease disease NN cord-009571-mygj2nd4 987 15 . . . cord-009571-mygj2nd4 988 1 The the DT cord-009571-mygj2nd4 988 2 number number NN cord-009571-mygj2nd4 988 3 of of IN cord-009571-mygj2nd4 988 4 samples sample NNS cord-009571-mygj2nd4 988 5 with with IN cord-009571-mygj2nd4 988 6 abnormal abnormal JJ cord-009571-mygj2nd4 988 7 CSF csf NN cord-009571-mygj2nd4 988 8 leukocyte leukocyte NN cord-009571-mygj2nd4 988 9 counts count NNS cord-009571-mygj2nd4 988 10 was be VBD cord-009571-mygj2nd4 988 11 significantly significantly RB cord-009571-mygj2nd4 988 12 greater great JJR cord-009571-mygj2nd4 988 13 for for IN cord-009571-mygj2nd4 988 14 group group NN cord-009571-mygj2nd4 988 15 I1 i1 NN cord-009571-mygj2nd4 988 16 ( ( -LRB- cord-009571-mygj2nd4 988 17 6/8 6/8 CD cord-009571-mygj2nd4 988 18 ) ) -RRB- cord-009571-mygj2nd4 988 19 compared compare VBN cord-009571-mygj2nd4 988 20 with with IN cord-009571-mygj2nd4 988 21 that that DT cord-009571-mygj2nd4 988 22 found find VBN cord-009571-mygj2nd4 988 23 for for IN cord-009571-mygj2nd4 988 24 group group NN cord-009571-mygj2nd4 988 25 111 111 CD cord-009571-mygj2nd4 988 26 ( ( -LRB- cord-009571-mygj2nd4 988 27 0/11 0/11 CD cord-009571-mygj2nd4 988 28 ) ) -RRB- cord-009571-mygj2nd4 988 29 ( ( -LRB- cord-009571-mygj2nd4 988 30 P p NN cord-009571-mygj2nd4 988 31 < < XX cord-009571-mygj2nd4 988 32 O.Ol).However O.Ol).However NNP cord-009571-mygj2nd4 988 33 , , , cord-009571-mygj2nd4 988 34 no no DT cord-009571-mygj2nd4 988 35 significant significant JJ cord-009571-mygj2nd4 988 36 difference difference NN cord-009571-mygj2nd4 988 37 was be VBD cord-009571-mygj2nd4 988 38 found find VBN cord-009571-mygj2nd4 988 39 between between IN cord-009571-mygj2nd4 988 40 group group NN cord-009571-mygj2nd4 988 41 I I NNP cord-009571-mygj2nd4 988 42 and and CC cord-009571-mygj2nd4 988 43 group group NN cord-009571-mygj2nd4 988 44 111 111 CD cord-009571-mygj2nd4 988 45 , , , cord-009571-mygj2nd4 988 46 for for IN cord-009571-mygj2nd4 988 47 this this DT cord-009571-mygj2nd4 988 48 abnormality abnormality NN cord-009571-mygj2nd4 988 49 . . . cord-009571-mygj2nd4 989 1 In in IN cord-009571-mygj2nd4 989 2 4 4 CD cord-009571-mygj2nd4 989 3 SLE SLE NNP cord-009571-mygj2nd4 989 4 patients patient NNS cord-009571-mygj2nd4 989 5 significantly significantly RB cord-009571-mygj2nd4 989 6 higher high JJR cord-009571-mygj2nd4 989 7 levels level NNS cord-009571-mygj2nd4 989 8 of of IN cord-009571-mygj2nd4 989 9 CSF CSF NNP cord-009571-mygj2nd4 989 10 C C NNP cord-009571-mygj2nd4 989 11 - - HYPH cord-009571-mygj2nd4 989 12 GMP GMP NNP cord-009571-mygj2nd4 989 13 were be VBD cord-009571-mygj2nd4 989 14 found find VBN cord-009571-mygj2nd4 989 15 on on IN cord-009571-mygj2nd4 989 16 serial serial JJ cord-009571-mygj2nd4 989 17 sampling sampling NN cord-009571-mygj2nd4 989 18 during during IN cord-009571-mygj2nd4 989 19 times time NNS cord-009571-mygj2nd4 989 20 when when WRB cord-009571-mygj2nd4 989 21 neurologic neurologic JJ cord-009571-mygj2nd4 989 22 abnormaltiies abnormaltiie NNS cord-009571-mygj2nd4 989 23 were be VBD cord-009571-mygj2nd4 989 24 active active JJ cord-009571-mygj2nd4 989 25 . . . cord-009571-mygj2nd4 990 1 Neither neither CC cord-009571-mygj2nd4 990 2 prednisone prednisone NN cord-009571-mygj2nd4 990 3 nor nor CC cord-009571-mygj2nd4 990 4 psychoactive psychoactive JJ cord-009571-mygj2nd4 990 5 drug drug NN cord-009571-mygj2nd4 990 6 therapy therapy NN cord-009571-mygj2nd4 990 7 had have VBD cord-009571-mygj2nd4 990 8 any any DT cord-009571-mygj2nd4 990 9 demonstrable demonstrable JJ cord-009571-mygj2nd4 990 10 effect effect NN cord-009571-mygj2nd4 990 11 on on IN cord-009571-mygj2nd4 990 12 CSF CSF NNP cord-009571-mygj2nd4 990 13 C C NNP cord-009571-mygj2nd4 990 14 - - HYPH cord-009571-mygj2nd4 990 15 GMP GMP NNP cord-009571-mygj2nd4 990 16 levels level NNS cord-009571-mygj2nd4 990 17 in in IN cord-009571-mygj2nd4 990 18 these these DT cord-009571-mygj2nd4 990 19 pa pa NNP cord-009571-mygj2nd4 990 20 - - HYPH cord-009571-mygj2nd4 990 21 tients tients NNP cord-009571-mygj2nd4 990 22 . . . cord-009571-mygj2nd4 991 1 Comparison comparison NN cord-009571-mygj2nd4 991 2 of of IN cord-009571-mygj2nd4 991 3 clinical clinical JJ cord-009571-mygj2nd4 991 4 markers marker NNS cord-009571-mygj2nd4 991 5 of of IN cord-009571-mygj2nd4 991 6 SLE SLE NNP cord-009571-mygj2nd4 991 7 disease disease NN cord-009571-mygj2nd4 991 8 activity activity NN cord-009571-mygj2nd4 991 9 among among IN cord-009571-mygj2nd4 991 10 the the DT cord-009571-mygj2nd4 991 11 three three CD cord-009571-mygj2nd4 991 12 groups group NNS cord-009571-mygj2nd4 991 13 revealed reveal VBD cord-009571-mygj2nd4 991 14 hematologic hematologic JJ cord-009571-mygj2nd4 991 15 and and CC cord-009571-mygj2nd4 991 16 serologic serologic JJ cord-009571-mygj2nd4 991 17 abnormalities abnormality NNS cord-009571-mygj2nd4 991 18 not not RB cord-009571-mygj2nd4 991 19 to to TO cord-009571-mygj2nd4 991 20 be be VB cord-009571-mygj2nd4 991 21 of of IN cord-009571-mygj2nd4 991 22 significant significant JJ cord-009571-mygj2nd4 991 23 value value NN cord-009571-mygj2nd4 991 24 in in IN cord-009571-mygj2nd4 991 25 distinguishing distinguish VBG cord-009571-mygj2nd4 991 26 SLE SLE NNP cord-009571-mygj2nd4 991 27 patients patient NNS cord-009571-mygj2nd4 991 28 with with IN cord-009571-mygj2nd4 991 29 active active JJ cord-009571-mygj2nd4 991 30 neurolgic neurolgic JJ cord-009571-mygj2nd4 991 31 involvement involvement NN cord-009571-mygj2nd4 991 32 ( ( -LRB- cord-009571-mygj2nd4 991 33 groups group NNS cord-009571-mygj2nd4 991 34 I -PRON- PRP cord-009571-mygj2nd4 991 35 and and CC cord-009571-mygj2nd4 991 36 11 11 CD cord-009571-mygj2nd4 991 37 ) ) -RRB- cord-009571-mygj2nd4 991 38 from from IN cord-009571-mygj2nd4 991 39 those those DT cord-009571-mygj2nd4 991 40 without without IN cord-009571-mygj2nd4 991 41 ( ( -LRB- cord-009571-mygj2nd4 991 42 group group NN cord-009571-mygj2nd4 991 43 111 111 CD cord-009571-mygj2nd4 991 44 ) ) -RRB- cord-009571-mygj2nd4 991 45 . . . cord-009571-mygj2nd4 992 1 However however RB cord-009571-mygj2nd4 992 2 , , , cord-009571-mygj2nd4 992 3 fever fever NN cord-009571-mygj2nd4 992 4 and and CC cord-009571-mygj2nd4 992 5 , , , cord-009571-mygj2nd4 992 6 to to IN cord-009571-mygj2nd4 992 7 a a DT cord-009571-mygj2nd4 992 8 lesser less JJR cord-009571-mygj2nd4 992 9 degree degree NN cord-009571-mygj2nd4 992 10 , , , cord-009571-mygj2nd4 992 11 rash rash JJ cord-009571-mygj2nd4 992 12 , , , cord-009571-mygj2nd4 992 13 proteinuria proteinuria NN cord-009571-mygj2nd4 992 14 , , , cord-009571-mygj2nd4 992 15 and and CC cord-009571-mygj2nd4 992 16 abnormal abnormal JJ cord-009571-mygj2nd4 992 17 urinary urinary JJ cord-009571-mygj2nd4 992 18 sediment sediment NN cord-009571-mygj2nd4 992 19 were be VBD cord-009571-mygj2nd4 992 20 present present JJ cord-009571-mygj2nd4 992 21 more more RBR cord-009571-mygj2nd4 992 22 frequently frequently RB cord-009571-mygj2nd4 992 23 in in IN cord-009571-mygj2nd4 992 24 groups group NNS cord-009571-mygj2nd4 993 1 I -PRON- PRP cord-009571-mygj2nd4 993 2 and and CC cord-009571-mygj2nd4 993 3 I1 i1 NN cord-009571-mygj2nd4 993 4 than than IN cord-009571-mygj2nd4 993 5 in in IN cord-009571-mygj2nd4 993 6 group group NN cord-009571-mygj2nd4 993 7 111 111 CD cord-009571-mygj2nd4 993 8 . . . cord-009571-mygj2nd4 994 1 Thus thus RB cord-009571-mygj2nd4 994 2 elevated elevate VBN cord-009571-mygj2nd4 994 3 CSF CSF NNP cord-009571-mygj2nd4 994 4 C C NNP cord-009571-mygj2nd4 994 5 - - HYPH cord-009571-mygj2nd4 994 6 GMP GMP NNP cord-009571-mygj2nd4 994 7 concentration concentration NN cord-009571-mygj2nd4 994 8 may may MD cord-009571-mygj2nd4 994 9 be be VB cord-009571-mygj2nd4 994 10 a a DT cord-009571-mygj2nd4 994 11 marker marker NN cord-009571-mygj2nd4 994 12 of of IN cord-009571-mygj2nd4 994 13 active active JJ cord-009571-mygj2nd4 994 14 neurologic neurologic JJ cord-009571-mygj2nd4 994 15 disease disease NN cord-009571-mygj2nd4 994 16 in in IN cord-009571-mygj2nd4 994 17 SLE SLE NNP cord-009571-mygj2nd4 994 18 . . . cord-009571-mygj2nd4 995 1 Assay Assay NNP cord-009571-mygj2nd4 995 2 of of IN cord-009571-mygj2nd4 995 3 CSF CSF NNP cord-009571-mygj2nd4 995 4 C C NNP cord-009571-mygj2nd4 995 5 - - HYPH cord-009571-mygj2nd4 995 6 G G NNP cord-009571-mygj2nd4 995 7 M m NN cord-009571-mygj2nd4 995 8 P p NN cord-009571-mygj2nd4 995 9 may may MD cord-009571-mygj2nd4 995 10 therefore therefore RB cord-009571-mygj2nd4 995 11 be be VB cord-009571-mygj2nd4 995 12 helpful helpful JJ cord-009571-mygj2nd4 995 13 in in IN cord-009571-mygj2nd4 995 14 the the DT cord-009571-mygj2nd4 995 15 clinical clinical JJ cord-009571-mygj2nd4 995 16 assessment assessment NN cord-009571-mygj2nd4 995 17 of of IN cord-009571-mygj2nd4 995 18 SLE SLE NNP cord-009571-mygj2nd4 995 19 patients patient NNS cord-009571-mygj2nd4 995 20 with with IN cord-009571-mygj2nd4 995 21 neurologic neurologic JJ cord-009571-mygj2nd4 995 22 and/or and/or CC cord-009571-mygj2nd4 995 23 psychologic psychologic JJ cord-009571-mygj2nd4 995 24 abnormalities abnormality NNS cord-009571-mygj2nd4 995 25 both both DT cord-009571-mygj2nd4 995 26 with with IN cord-009571-mygj2nd4 995 27 regard regard NN cord-009571-mygj2nd4 995 28 to to IN cord-009571-mygj2nd4 995 29 their -PRON- PRP$ cord-009571-mygj2nd4 995 30 diagnosis diagnosis NN cord-009571-mygj2nd4 995 31 and and CC cord-009571-mygj2nd4 995 32 therapy therapy NN cord-009571-mygj2nd4 995 33 . . . cord-009571-mygj2nd4 996 1 This this DT cord-009571-mygj2nd4 996 2 study study NN cord-009571-mygj2nd4 996 3 reports report VBZ cord-009571-mygj2nd4 996 4 the the DT cord-009571-mygj2nd4 996 5 first first JJ cord-009571-mygj2nd4 996 6 serial serial JJ cord-009571-mygj2nd4 996 7 observations observation NNS cord-009571-mygj2nd4 996 8 of of IN cord-009571-mygj2nd4 996 9 C C NNP cord-009571-mygj2nd4 996 10 - - HYPH cord-009571-mygj2nd4 996 11 GMP GMP NNP cord-009571-mygj2nd4 996 12 in in IN cord-009571-mygj2nd4 996 13 a a DT cord-009571-mygj2nd4 996 14 group group NN cord-009571-mygj2nd4 996 15 of of IN cord-009571-mygj2nd4 996 16 SLE SLE NNP cord-009571-mygj2nd4 996 17 patients patient NNS cord-009571-mygj2nd4 996 18 with with IN cord-009571-mygj2nd4 996 19 correlation correlation NN cord-009571-mygj2nd4 996 20 of of IN cord-009571-mygj2nd4 996 21 manifestations manifestation NNS cord-009571-mygj2nd4 996 22 of of IN cord-009571-mygj2nd4 996 23 disease disease NN cord-009571-mygj2nd4 996 24 activity activity NN cord-009571-mygj2nd4 996 25 and and CC cord-009571-mygj2nd4 996 26 extends extend VBZ cord-009571-mygj2nd4 996 27 our -PRON- PRP$ cord-009571-mygj2nd4 996 28 previous previous JJ cord-009571-mygj2nd4 996 29 studies study NNS cord-009571-mygj2nd4 996 30 of of IN cord-009571-mygj2nd4 996 31 cyclic cyclic JJ cord-009571-mygj2nd4 996 32 nucleotides nucleotide NNS cord-009571-mygj2nd4 996 33 in in IN cord-009571-mygj2nd4 996 34 SLE SLE NNP cord-009571-mygj2nd4 996 35 . . . cord-009571-mygj2nd4 997 1 Mp Mp NNP cord-009571-mygj2nd4 997 2 produces produce VBZ cord-009571-mygj2nd4 997 3 a a DT cord-009571-mygj2nd4 997 4 chronic chronic JJ cord-009571-mygj2nd4 997 5 arthritis arthritis NN cord-009571-mygj2nd4 997 6 in in IN cord-009571-mygj2nd4 997 7 mice mouse NNS cord-009571-mygj2nd4 997 8 with with IN cord-009571-mygj2nd4 997 9 histopathologic histopathologic NNP cord-009571-mygj2nd4 997 10 features feature NNS cord-009571-mygj2nd4 997 11 resembling resemble VBG cord-009571-mygj2nd4 997 12 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 997 13 arthritis arthritis NN cord-009571-mygj2nd4 997 14 . . . cord-009571-mygj2nd4 998 1 Since since IN cord-009571-mygj2nd4 998 2 the the DT cord-009571-mygj2nd4 998 3 chronicity chronicity NN cord-009571-mygj2nd4 998 4 of of IN cord-009571-mygj2nd4 998 5 arthritis arthritis NN cord-009571-mygj2nd4 998 6 appears appear VBZ cord-009571-mygj2nd4 998 7 to to TO cord-009571-mygj2nd4 998 8 result result VB cord-009571-mygj2nd4 998 9 in in IN cord-009571-mygj2nd4 998 10 part part NN cord-009571-mygj2nd4 998 11 from from IN cord-009571-mygj2nd4 998 12 persistence persistence NN cord-009571-mygj2nd4 998 13 of of IN cord-009571-mygj2nd4 998 14 Mp Mp NNP cord-009571-mygj2nd4 998 15 within within IN cord-009571-mygj2nd4 998 16 the the DT cord-009571-mygj2nd4 998 17 joints joint NNS cord-009571-mygj2nd4 998 18 , , , cord-009571-mygj2nd4 998 19 elucidation elucidation NN cord-009571-mygj2nd4 998 20 of of IN cord-009571-mygj2nd4 998 21 host host NN cord-009571-mygj2nd4 998 22 mechanisms mechanism NNS cord-009571-mygj2nd4 998 23 responsible responsible JJ cord-009571-mygj2nd4 998 24 for for IN cord-009571-mygj2nd4 998 25 elimination elimination NN cord-009571-mygj2nd4 998 26 of of IN cord-009571-mygj2nd4 998 27 Mp Mp NNP cord-009571-mygj2nd4 998 28 is be VBZ cord-009571-mygj2nd4 998 29 of of IN cord-009571-mygj2nd4 998 30 considerable considerable JJ cord-009571-mygj2nd4 998 31 importance importance NN cord-009571-mygj2nd4 998 32 . . . cord-009571-mygj2nd4 999 1 The the DT cord-009571-mygj2nd4 999 2 role role NN cord-009571-mygj2nd4 999 3 of of IN cord-009571-mygj2nd4 999 4 complement complement NN cord-009571-mygj2nd4 999 5 in in IN cord-009571-mygj2nd4 999 6 the the DT cord-009571-mygj2nd4 999 7 pathogenesis pathogenesis NN cord-009571-mygj2nd4 999 8 of of IN cord-009571-mygj2nd4 999 9 Mp Mp NNP cord-009571-mygj2nd4 999 10 - - HYPH cord-009571-mygj2nd4 999 11 induced induce VBN cord-009571-mygj2nd4 999 12 arthritis arthritis NN cord-009571-mygj2nd4 999 13 was be VBD cord-009571-mygj2nd4 999 14 studied study VBN cord-009571-mygj2nd4 999 15 in in IN cord-009571-mygj2nd4 999 16 mice mouse NNS cord-009571-mygj2nd4 999 17 congenitally congenitally RB cord-009571-mygj2nd4 999 18 deficient deficient JJ cord-009571-mygj2nd4 999 19 in in IN cord-009571-mygj2nd4 999 20 the the DT cord-009571-mygj2nd4 999 21 fifth fifth JJ cord-009571-mygj2nd4 999 22 component component NN cord-009571-mygj2nd4 999 23 of of IN cord-009571-mygj2nd4 999 24 complement complement NN cord-009571-mygj2nd4 999 25 ( ( -LRB- cord-009571-mygj2nd4 999 26 C5 C5 NNP cord-009571-mygj2nd4 999 27 ) ) -RRB- cord-009571-mygj2nd4 999 28 . . . cord-009571-mygj2nd4 1000 1 In in IN cord-009571-mygj2nd4 1000 2 all all DT cord-009571-mygj2nd4 1000 3 experiments experiment NNS cord-009571-mygj2nd4 1000 4 , , , cord-009571-mygj2nd4 1000 5 at at IN cord-009571-mygj2nd4 1000 6 least least JJS cord-009571-mygj2nd4 1000 7 5.5-week 5.5-week CD cord-009571-mygj2nd4 1000 8 - - HYPH cord-009571-mygj2nd4 1000 9 old old JJ cord-009571-mygj2nd4 1000 10 male male JJ cord-009571-mygj2nd4 1000 11 mice mouse NNS cord-009571-mygj2nd4 1000 12 per per IN cord-009571-mygj2nd4 1000 13 strain strain NN cord-009571-mygj2nd4 1000 14 free free JJ cord-009571-mygj2nd4 1000 15 of of IN cord-009571-mygj2nd4 1000 16 detectable detectable JJ cord-009571-mygj2nd4 1000 17 mycoplasmas mycoplasma NNS cord-009571-mygj2nd4 1000 18 were be VBD cord-009571-mygj2nd4 1000 19 inoculated inoculate VBN cord-009571-mygj2nd4 1000 20 intravenously intravenously RB cord-009571-mygj2nd4 1000 21 with with IN cord-009571-mygj2nd4 1000 22 2 2 CD cord-009571-mygj2nd4 1000 23 X x NN cord-009571-mygj2nd4 1000 24 1P 1p NN cord-009571-mygj2nd4 1000 25 color color NN cord-009571-mygj2nd4 1000 26 change change NN cord-009571-mygj2nd4 1000 27 units unit NNS cord-009571-mygj2nd4 1000 28 of of IN cord-009571-mygj2nd4 1000 29 Mp Mp NNP cord-009571-mygj2nd4 1000 30 . . . cord-009571-mygj2nd4 1001 1 Subjective subjective JJ cord-009571-mygj2nd4 1001 2 assessment assessment NN cord-009571-mygj2nd4 1001 3 of of IN cord-009571-mygj2nd4 1001 4 the the DT cord-009571-mygj2nd4 1001 5 arthritis arthritis NN cord-009571-mygj2nd4 1001 6 was be VBD cord-009571-mygj2nd4 1001 7 carried carry VBN cord-009571-mygj2nd4 1001 8 out out RP cord-009571-mygj2nd4 1001 9 by by IN cord-009571-mygj2nd4 1001 10 scoring score VBG cord-009571-mygj2nd4 1001 11 ankles ankle NNS cord-009571-mygj2nd4 1001 12 , , , cord-009571-mygj2nd4 1001 13 wrists wrist NNS cord-009571-mygj2nd4 1001 14 , , , cord-009571-mygj2nd4 1001 15 qetacarpal qetacarpal NNP cord-009571-mygj2nd4 1001 16 , , , cord-009571-mygj2nd4 1001 17 metatarsal metatarsal NN cord-009571-mygj2nd4 1001 18 , , , cord-009571-mygj2nd4 1001 19 and and CC cord-009571-mygj2nd4 1001 20 digital digital JJ cord-009571-mygj2nd4 1001 21 joints joint NNS cord-009571-mygj2nd4 1001 22 on on IN cord-009571-mygj2nd4 1001 23 a a DT cord-009571-mygj2nd4 1001 24 scale scale NN cord-009571-mygj2nd4 1001 25 of of IN cord-009571-mygj2nd4 1001 26 0 0 CD cord-009571-mygj2nd4 1001 27 to to IN cord-009571-mygj2nd4 1001 28 3 3 CD cord-009571-mygj2nd4 1001 29 . . . cord-009571-mygj2nd4 1002 1 In in IN cord-009571-mygj2nd4 1002 2 a a DT cord-009571-mygj2nd4 1002 3 preliminary preliminary JJ cord-009571-mygj2nd4 1002 4 study study NN cord-009571-mygj2nd4 1002 5 C5 c5 NN cord-009571-mygj2nd4 1002 6 deficient deficient JJ cord-009571-mygj2nd4 1002 7 DBA/2 DBA/2 NNP cord-009571-mygj2nd4 1002 8 mice mouse NNS cord-009571-mygj2nd4 1002 9 and and CC cord-009571-mygj2nd4 1002 10 4 4 CD cord-009571-mygj2nd4 1002 11 strains strain NNS cord-009571-mygj2nd4 1002 12 of of IN cord-009571-mygj2nd4 1002 13 normal normal JJ cord-009571-mygj2nd4 1002 14 mice mouse NNS cord-009571-mygj2nd4 1002 15 : : : cord-009571-mygj2nd4 1002 16 T.O. T.O. NNP cord-009571-mygj2nd4 1002 17 , , , cord-009571-mygj2nd4 1002 18 C3H C3H VBN cord-009571-mygj2nd4 1002 19 , , , cord-009571-mygj2nd4 1002 20 CBA CBA NNP cord-009571-mygj2nd4 1002 21 , , , cord-009571-mygj2nd4 1002 22 and and CC cord-009571-mygj2nd4 1002 23 C57BL/10 C57BL/10 NNP cord-009571-mygj2nd4 1002 24 were be VBD cord-009571-mygj2nd4 1002 25 used use VBN cord-009571-mygj2nd4 1002 26 . . . cord-009571-mygj2nd4 1003 1 In in IN cord-009571-mygj2nd4 1003 2 the the DT cord-009571-mygj2nd4 1003 3 normal normal JJ cord-009571-mygj2nd4 1003 4 strains strain NNS cord-009571-mygj2nd4 1003 5 the the DT cord-009571-mygj2nd4 1003 6 .arthritis .arthritis NN cord-009571-mygj2nd4 1003 7 peaked peak VBD cord-009571-mygj2nd4 1003 8 in in IN cord-009571-mygj2nd4 1003 9 severity severity NN cord-009571-mygj2nd4 1003 10 within within IN cord-009571-mygj2nd4 1003 11 15 15 CD cord-009571-mygj2nd4 1003 12 days day NNS cord-009571-mygj2nd4 1003 13 and and CC cord-009571-mygj2nd4 1003 14 declined decline VBD cord-009571-mygj2nd4 1003 15 thereafter thereafter RB cord-009571-mygj2nd4 1003 16 . . . cord-009571-mygj2nd4 1004 1 In in IN cord-009571-mygj2nd4 1004 2 contrast contrast NN cord-009571-mygj2nd4 1004 3 the the DT cord-009571-mygj2nd4 1004 4 arthritis arthritis NN cord-009571-mygj2nd4 1004 5 in in IN cord-009571-mygj2nd4 1004 6 the the DT cord-009571-mygj2nd4 1004 7 DBA/2 DBA/2 NNP cord-009571-mygj2nd4 1004 8 mice mouse NNS cord-009571-mygj2nd4 1004 9 reached reach VBD cord-009571-mygj2nd4 1004 10 a a DT cord-009571-mygj2nd4 1004 11 plateau plateau NN cord-009571-mygj2nd4 1004 12 at at IN cord-009571-mygj2nd4 1004 13 15 15 CD cord-009571-mygj2nd4 1004 14 days day NNS cord-009571-mygj2nd4 1004 15 and and CC cord-009571-mygj2nd4 1004 16 gradually gradually RB cord-009571-mygj2nd4 1004 17 progressed progress VBD cord-009571-mygj2nd4 1004 18 in in IN cord-009571-mygj2nd4 1004 19 severity severity NN cord-009571-mygj2nd4 1004 20 for for IN cord-009571-mygj2nd4 1004 21 as as RB cord-009571-mygj2nd4 1004 22 long long JJ cord-009571-mygj2nd4 1004 23 as as IN cord-009571-mygj2nd4 1004 24 5 5 CD cord-009571-mygj2nd4 1004 25 months month NNS cord-009571-mygj2nd4 1004 26 postinoculation postinoculation NN cord-009571-mygj2nd4 1004 27 . . . cord-009571-mygj2nd4 1005 1 A a DT cord-009571-mygj2nd4 1005 2 second second JJ cord-009571-mygj2nd4 1005 3 study study NN cord-009571-mygj2nd4 1005 4 was be VBD cord-009571-mygj2nd4 1005 5 carried carry VBN cord-009571-mygj2nd4 1005 6 out out RP cord-009571-mygj2nd4 1005 7 with with IN cord-009571-mygj2nd4 1005 8 3 3 CD cord-009571-mygj2nd4 1005 9 strains strain NNS cord-009571-mygj2nd4 1005 10 of of IN cord-009571-mygj2nd4 1005 11 C5 c5 NN cord-009571-mygj2nd4 1005 12 deficient deficient JJ cord-009571-mygj2nd4 1005 13 mice mouse NNS cord-009571-mygj2nd4 1005 14 , , , cord-009571-mygj2nd4 1005 15 i.e. i.e. FW cord-009571-mygj2nd4 1005 16 DBA/2 DBA/2 NNP cord-009571-mygj2nd4 1005 17 , , , cord-009571-mygj2nd4 1005 18 AKR AKR NNP cord-009571-mygj2nd4 1005 19 and and CC cord-009571-mygj2nd4 1005 20 A a DT cord-009571-mygj2nd4 1005 21 strain strain NN cord-009571-mygj2nd4 1005 22 and and CC cord-009571-mygj2nd4 1005 23 2 2 CD cord-009571-mygj2nd4 1005 24 normal normal JJ cord-009571-mygj2nd4 1005 25 strains strain NNS cord-009571-mygj2nd4 1005 26 : : : cord-009571-mygj2nd4 1005 27 C3H C3H VBN cord-009571-mygj2nd4 1005 28 and and CC cord-009571-mygj2nd4 1005 29 C57BL/10 C57BL/10 NNP cord-009571-mygj2nd4 1005 30 . . . cord-009571-mygj2nd4 1006 1 The the DT cord-009571-mygj2nd4 1006 2 arthritis arthritis NN cord-009571-mygj2nd4 1006 3 in in IN cord-009571-mygj2nd4 1006 4 the the DT cord-009571-mygj2nd4 1006 5 C5 C5 NNP cord-009571-mygj2nd4 1006 6 deficient deficient JJ cord-009571-mygj2nd4 1006 7 strains strain NNS cord-009571-mygj2nd4 1006 8 persisted persist VBD cord-009571-mygj2nd4 1006 9 at at IN cord-009571-mygj2nd4 1006 10 a a DT cord-009571-mygj2nd4 1006 11 high high JJ cord-009571-mygj2nd4 1006 12 level level NN cord-009571-mygj2nd4 1006 13 3 3 CD cord-009571-mygj2nd4 1006 14 months month NNS cord-009571-mygj2nd4 1006 15 after after IN cord-009571-mygj2nd4 1006 16 inoculation inoculation NN cord-009571-mygj2nd4 1006 17 despite despite IN cord-009571-mygj2nd4 1006 18 considerable considerable JJ cord-009571-mygj2nd4 1006 19 variability variability NN cord-009571-mygj2nd4 1006 20 in in IN cord-009571-mygj2nd4 1006 21 the the DT cord-009571-mygj2nd4 1006 22 severity severity NN cord-009571-mygj2nd4 1006 23 of of IN cord-009571-mygj2nd4 1006 24 the the DT cord-009571-mygj2nd4 1006 25 acute acute JJ cord-009571-mygj2nd4 1006 26 arthritis arthritis NN cord-009571-mygj2nd4 1006 27 among among IN cord-009571-mygj2nd4 1006 28 the the DT cord-009571-mygj2nd4 1006 29 strains strain NNS cord-009571-mygj2nd4 1006 30 . . . cord-009571-mygj2nd4 1007 1 The the DT cord-009571-mygj2nd4 1007 2 arthritis arthritis NN cord-009571-mygj2nd4 1007 3 in in IN cord-009571-mygj2nd4 1007 4 the the DT cord-009571-mygj2nd4 1007 5 normal normal JJ cord-009571-mygj2nd4 1007 6 strains strain NNS cord-009571-mygj2nd4 1007 7 rapidly rapidly RB cord-009571-mygj2nd4 1007 8 declined decline VBD cord-009571-mygj2nd4 1007 9 as as IN cord-009571-mygj2nd4 1007 10 before before RB cord-009571-mygj2nd4 1007 11 . . . cord-009571-mygj2nd4 1008 1 At at IN cord-009571-mygj2nd4 1008 2 3 3 CD cord-009571-mygj2nd4 1008 3 months month NNS cord-009571-mygj2nd4 1008 4 postinoculation postinoculation NN cord-009571-mygj2nd4 1008 5 , , , cord-009571-mygj2nd4 1008 6 Mp Mp NNP cord-009571-mygj2nd4 1008 7 was be VBD cord-009571-mygj2nd4 1008 8 isolated isolate VBN cord-009571-mygj2nd4 1008 9 from from IN cord-009571-mygj2nd4 1008 10 the the DT cord-009571-mygj2nd4 1008 11 joints joint NNS cord-009571-mygj2nd4 1008 12 , , , cord-009571-mygj2nd4 1008 13 lungs lung NNS cord-009571-mygj2nd4 1008 14 , , , cord-009571-mygj2nd4 1008 15 and and CC cord-009571-mygj2nd4 1008 16 spleens spleen NNS cord-009571-mygj2nd4 1008 17 of of IN cord-009571-mygj2nd4 1008 18 C5 c5 NN cord-009571-mygj2nd4 1008 19 deficient deficient JJ cord-009571-mygj2nd4 1008 20 mice mouse NNS cord-009571-mygj2nd4 1008 21 more more RBR cord-009571-mygj2nd4 1008 22 frequently frequently RB cord-009571-mygj2nd4 1008 23 and and CC cord-009571-mygj2nd4 1008 24 in in IN cord-009571-mygj2nd4 1008 25 larger large JJR cord-009571-mygj2nd4 1008 26 numbers number NNS cord-009571-mygj2nd4 1008 27 than than IN cord-009571-mygj2nd4 1008 28 from from IN cord-009571-mygj2nd4 1008 29 normal normal JJ cord-009571-mygj2nd4 1008 30 mice mouse NNS cord-009571-mygj2nd4 1008 31 , , , cord-009571-mygj2nd4 1008 32 consistent consistent JJ cord-009571-mygj2nd4 1008 33 with with IN cord-009571-mygj2nd4 1008 34 the the DT cord-009571-mygj2nd4 1008 35 failure failure NN cord-009571-mygj2nd4 1008 36 of of IN cord-009571-mygj2nd4 1008 37 CS CS NNP cord-009571-mygj2nd4 1008 38 deficient deficient JJ cord-009571-mygj2nd4 1008 39 mice mouse NNS cord-009571-mygj2nd4 1008 40 to to TO cord-009571-mygj2nd4 1008 41 eliminate eliminate VB cord-009571-mygj2nd4 1008 42 Mp Mp NNP cord-009571-mygj2nd4 1008 43 . . . cord-009571-mygj2nd4 1008 44 Complement complement NN cord-009571-mygj2nd4 1008 45 - - HYPH cord-009571-mygj2nd4 1008 46 fixing fix VBG cord-009571-mygj2nd4 1008 47 antibody antibody NN cord-009571-mygj2nd4 1008 48 to to IN cord-009571-mygj2nd4 1008 49 Mp Mp NNP cord-009571-mygj2nd4 1008 50 was be VBD cord-009571-mygj2nd4 1008 51 detected detect VBN cord-009571-mygj2nd4 1008 52 in in IN cord-009571-mygj2nd4 1008 53 higher high JJR cord-009571-mygj2nd4 1008 54 titers titer NNS cord-009571-mygj2nd4 1008 55 in in IN cord-009571-mygj2nd4 1008 56 C5 c5 NN cord-009571-mygj2nd4 1008 57 deficient deficient JJ cord-009571-mygj2nd4 1008 58 strains strain NNS cord-009571-mygj2nd4 1008 59 . . . cord-009571-mygj2nd4 1009 1 The the DT cord-009571-mygj2nd4 1009 2 results result NNS cord-009571-mygj2nd4 1009 3 demonstrate demonstrate VBP cord-009571-mygj2nd4 1009 4 the the DT cord-009571-mygj2nd4 1009 5 importance importance NN cord-009571-mygj2nd4 1009 6 of of IN cord-009571-mygj2nd4 1009 7 C5 C5 NNP cord-009571-mygj2nd4 1009 8 in in IN cord-009571-mygj2nd4 1009 9 the the DT cord-009571-mygj2nd4 1009 10 elimination elimination NN cord-009571-mygj2nd4 1009 11 of of IN cord-009571-mygj2nd4 1009 12 Mp Mp NNP cord-009571-mygj2nd4 1009 13 from from IN cord-009571-mygj2nd4 1009 14 the the DT cord-009571-mygj2nd4 1009 15 joints joint NNS cord-009571-mygj2nd4 1009 16 and and CC cord-009571-mygj2nd4 1009 17 organs organ NNS cord-009571-mygj2nd4 1009 18 of of IN cord-009571-mygj2nd4 1009 19 infected infected JJ cord-009571-mygj2nd4 1009 20 mice mouse NNS cord-009571-mygj2nd4 1009 21 . . . cord-009571-mygj2nd4 1010 1 Moreover moreover RB cord-009571-mygj2nd4 1010 2 , , , cord-009571-mygj2nd4 1010 3 the the DT cord-009571-mygj2nd4 1010 4 study study NN cord-009571-mygj2nd4 1010 5 may may MD cord-009571-mygj2nd4 1010 6 have have VB cord-009571-mygj2nd4 1010 7 clinical clinical JJ cord-009571-mygj2nd4 1010 8 relevance relevance NN cord-009571-mygj2nd4 1010 9 since since IN cord-009571-mygj2nd4 1010 10 secondary secondary JJ cord-009571-mygj2nd4 1010 11 complement complement NN cord-009571-mygj2nd4 1010 12 deficiencies deficiency NNS cord-009571-mygj2nd4 1010 13 exist exist VBP cord-009571-mygj2nd4 1010 14 in in IN cord-009571-mygj2nd4 1010 15 a a DT cord-009571-mygj2nd4 1010 16 number number NN cord-009571-mygj2nd4 1010 17 of of IN cord-009571-mygj2nd4 1010 18 rheumatic rheumatic JJ cord-009571-mygj2nd4 1010 19 diseases disease NNS cord-009571-mygj2nd4 1010 20 . . . cord-009571-mygj2nd4 1011 1 It -PRON- PRP cord-009571-mygj2nd4 1011 2 supports support VBZ cord-009571-mygj2nd4 1011 3 the the DT cord-009571-mygj2nd4 1011 4 concept concept NN cord-009571-mygj2nd4 1011 5 that that WDT cord-009571-mygj2nd4 1011 6 complement complement JJ cord-009571-mygj2nd4 1011 7 deficiency deficiency NN cord-009571-mygj2nd4 1011 8 might may MD cord-009571-mygj2nd4 1011 9 contribute contribute VB cord-009571-mygj2nd4 1011 10 to to IN cord-009571-mygj2nd4 1011 11 the the DT cord-009571-mygj2nd4 1011 12 persistence persistence NN cord-009571-mygj2nd4 1011 13 of of IN cord-009571-mygj2nd4 1011 14 as as RB cord-009571-mygj2nd4 1011 15 yet yet RB cord-009571-mygj2nd4 1011 16 undefined undefined JJ cord-009571-mygj2nd4 1011 17 etiologic etiologic JJ cord-009571-mygj2nd4 1011 18 agents agent NNS cord-009571-mygj2nd4 1011 19 in in IN cord-009571-mygj2nd4 1011 20 human human JJ cord-009571-mygj2nd4 1011 21 arthritidies arthritidie NNS cord-009571-mygj2nd4 1011 22 . . . cord-009571-mygj2nd4 1012 1 We -PRON- PRP cord-009571-mygj2nd4 1012 2 have have VBP cord-009571-mygj2nd4 1012 3 studied study VBN cord-009571-mygj2nd4 1012 4 34 34 CD cord-009571-mygj2nd4 1012 5 American American NNP cord-009571-mygj2nd4 1012 6 Black Black NNP cord-009571-mygj2nd4 1012 7 patients patient NNS cord-009571-mygj2nd4 1012 8 with with IN cord-009571-mygj2nd4 1012 9 primary primary JJ cord-009571-mygj2nd4 1012 10 ankylosing ankylosing NN cord-009571-mygj2nd4 1012 11 spondylitis spondylitis NN cord-009571-mygj2nd4 1012 12 ( ( -LRB- cord-009571-mygj2nd4 1012 13 AS as RB cord-009571-mygj2nd4 1012 14 ) ) -RRB- cord-009571-mygj2nd4 1012 15 unassociated unassociate VBN cord-009571-mygj2nd4 1012 16 with with IN cord-009571-mygj2nd4 1012 17 ulcerative ulcerative JJ cord-009571-mygj2nd4 1012 18 colitis colitis NN cord-009571-mygj2nd4 1012 19 , , , cord-009571-mygj2nd4 1012 20 Crohn Crohn NNP cord-009571-mygj2nd4 1012 21 's 's POS cord-009571-mygj2nd4 1012 22 disease disease NN cord-009571-mygj2nd4 1012 23 , , , cord-009571-mygj2nd4 1012 24 psoriasis psoriasis NN cord-009571-mygj2nd4 1012 25 , , , cord-009571-mygj2nd4 1012 26 or or CC cord-009571-mygj2nd4 1012 27 Reiter Reiter NNP cord-009571-mygj2nd4 1012 28 's 's POS cord-009571-mygj2nd4 1012 29 syndrome syndrome NN cord-009571-mygj2nd4 1012 30 . . . cord-009571-mygj2nd4 1013 1 All all PDT cord-009571-mygj2nd4 1013 2 the the DT cord-009571-mygj2nd4 1013 3 patients patient NNS cord-009571-mygj2nd4 1013 4 were be VBD cord-009571-mygj2nd4 1013 5 unrelated unrelated JJ cord-009571-mygj2nd4 1013 6 and and CC cord-009571-mygj2nd4 1013 7 met meet VBD cord-009571-mygj2nd4 1013 8 the the DT cord-009571-mygj2nd4 1013 9 Rome Rome NNP cord-009571-mygj2nd4 1013 10 criteria criterion NNS cord-009571-mygj2nd4 1013 11 for for IN cord-009571-mygj2nd4 1013 12 AS AS NNP cord-009571-mygj2nd4 1013 13 . . . cord-009571-mygj2nd4 1014 1 Sixteen Sixteen NNP cord-009571-mygj2nd4 1014 2 ( ( -LRB- cord-009571-mygj2nd4 1014 3 47 47 CD cord-009571-mygj2nd4 1014 4 % % NN cord-009571-mygj2nd4 1014 5 ) ) -RRB- cord-009571-mygj2nd4 1014 6 of of IN cord-009571-mygj2nd4 1014 7 them -PRON- PRP cord-009571-mygj2nd4 1014 8 possessed possess VBD cord-009571-mygj2nd4 1014 9 HLA HLA NNP cord-009571-mygj2nd4 1014 10 - - HYPH cord-009571-mygj2nd4 1014 11 B27 B27 NNP cord-009571-mygj2nd4 1014 12 . . . cord-009571-mygj2nd4 1015 1 We -PRON- PRP cord-009571-mygj2nd4 1015 2 further further RB cord-009571-mygj2nd4 1015 3 studied study VBD cord-009571-mygj2nd4 1015 4 the the DT cord-009571-mygj2nd4 1015 5 remaining remain VBG cord-009571-mygj2nd4 1015 6 18 18 CD cord-009571-mygj2nd4 1015 7 HLA HLA NNP cord-009571-mygj2nd4 1015 8 - - HYPH cord-009571-mygj2nd4 1015 9 B27-negative B27-negative NNP cord-009571-mygj2nd4 1015 10 patients patient NNS cord-009571-mygj2nd4 1015 11 to to TO cord-009571-mygj2nd4 1015 12 see see VB cord-009571-mygj2nd4 1015 13 if if IN cord-009571-mygj2nd4 1015 14 there there EX cord-009571-mygj2nd4 1015 15 was be VBD cord-009571-mygj2nd4 1015 16 an an DT cord-009571-mygj2nd4 1015 17 association association NN cord-009571-mygj2nd4 1015 18 with with IN cord-009571-mygj2nd4 1015 19 other other JJ cord-009571-mygj2nd4 1015 20 B B NNP cord-009571-mygj2nd4 1015 21 locus locus NN cord-009571-mygj2nd4 1015 22 antigens antigen NNS cord-009571-mygj2nd4 1015 23 belonging belong VBG cord-009571-mygj2nd4 1015 24 to to IN cord-009571-mygj2nd4 1015 25 the the DT cord-009571-mygj2nd4 1015 26 HLA HLA NNP cord-009571-mygj2nd4 1015 27 - - HYPH cord-009571-mygj2nd4 1015 28 B7 b7 NN cord-009571-mygj2nd4 1015 29 cross cross JJ cord-009571-mygj2nd4 1015 30 - - JJ cord-009571-mygj2nd4 1015 31 reactive reactive JJ cord-009571-mygj2nd4 1015 32 group group NN cord-009571-mygj2nd4 1015 33 ( ( -LRB- cord-009571-mygj2nd4 1015 34 HLA HLA NNP cord-009571-mygj2nd4 1015 35 - - HYPH cord-009571-mygj2nd4 1015 36 B7 B7 NNP cord-009571-mygj2nd4 1015 37 , , , cord-009571-mygj2nd4 1015 38 B27 B27 NNP cord-009571-mygj2nd4 1015 39 , , , cord-009571-mygj2nd4 1015 40 Bw22 Bw22 NNP cord-009571-mygj2nd4 1015 41 and and CC cord-009571-mygj2nd4 1015 42 Bw42 Bw42 NNP cord-009571-mygj2nd4 1015 43 ) ) -RRB- cord-009571-mygj2nd4 1015 44 . . . cord-009571-mygj2nd4 1016 1 HLA HLA NNP cord-009571-mygj2nd4 1016 2 - - HYPH cord-009571-mygj2nd4 1016 3 B7 B7 NNP cord-009571-mygj2nd4 1016 4 was be VBD cord-009571-mygj2nd4 1016 5 present present JJ cord-009571-mygj2nd4 1016 6 in in IN cord-009571-mygj2nd4 1016 7 10 10 CD cord-009571-mygj2nd4 1016 8 of of IN cord-009571-mygj2nd4 1016 9 these these DT cord-009571-mygj2nd4 1016 10 18 18 CD cord-009571-mygj2nd4 1016 11 patients patient NNS cord-009571-mygj2nd4 1016 12 ( ( -LRB- cord-009571-mygj2nd4 1016 13 55.6 55.6 CD cord-009571-mygj2nd4 1016 14 % % NN cord-009571-mygj2nd4 1016 15 ) ) -RRB- cord-009571-mygj2nd4 1016 16 compared compare VBN cord-009571-mygj2nd4 1016 17 to to IN cord-009571-mygj2nd4 1016 18 14 14 CD cord-009571-mygj2nd4 1016 19 of of IN cord-009571-mygj2nd4 1016 20 59 59 CD cord-009571-mygj2nd4 1016 21 ( ( -LRB- cord-009571-mygj2nd4 1016 22 23.7 23.7 CD cord-009571-mygj2nd4 1016 23 % % NN cord-009571-mygj2nd4 1016 24 ) ) -RRB- cord-009571-mygj2nd4 1017 1 B27-negative B27-negative NNP cord-009571-mygj2nd4 1017 2 Black Black NNP cord-009571-mygj2nd4 1017 3 controls control NNS cord-009571-mygj2nd4 1017 4 ( ( -LRB- cord-009571-mygj2nd4 1018 1 x x LS cord-009571-mygj2nd4 1018 2 ' ' '' cord-009571-mygj2nd4 1018 3 with with IN cord-009571-mygj2nd4 1018 4 Yates Yates NNP cord-009571-mygj2nd4 1018 5 correction correction NN cord-009571-mygj2nd4 1018 6 = = SYM cord-009571-mygj2nd4 1018 7 5.11 5.11 CD cord-009571-mygj2nd4 1018 8 , , , cord-009571-mygj2nd4 1018 9 P p NN cord-009571-mygj2nd4 1018 10 < < XX cord-009571-mygj2nd4 1018 11 0.025 0.025 CD cord-009571-mygj2nd4 1018 12 , , , cord-009571-mygj2nd4 1018 13 relative relative JJ cord-009571-mygj2nd4 1018 14 risk risk NN cord-009571-mygj2nd4 1018 15 = = SYM cord-009571-mygj2nd4 1018 16 4 4 CD cord-009571-mygj2nd4 1018 17 ) ) -RRB- cord-009571-mygj2nd4 1018 18 . . . cord-009571-mygj2nd4 1019 1 Bw22 Bw22 NNP cord-009571-mygj2nd4 1019 2 was be VBD cord-009571-mygj2nd4 1019 3 found find VBN cord-009571-mygj2nd4 1019 4 in in IN cord-009571-mygj2nd4 1019 5 one one CD cord-009571-mygj2nd4 1019 6 patient patient NN cord-009571-mygj2nd4 1019 7 who who WP cord-009571-mygj2nd4 1019 8 also also RB cord-009571-mygj2nd4 1019 9 had have VBD cord-009571-mygj2nd4 1019 10 B7 b7 NN cord-009571-mygj2nd4 1019 11 . . . cord-009571-mygj2nd4 1020 1 Bw42 Bw42 NNP cord-009571-mygj2nd4 1020 2 was be VBD cord-009571-mygj2nd4 1020 3 not not RB cord-009571-mygj2nd4 1020 4 tested test VBN cord-009571-mygj2nd4 1020 5 for for IN cord-009571-mygj2nd4 1020 6 . . . cord-009571-mygj2nd4 1021 1 Antisera Antisera NNP cord-009571-mygj2nd4 1021 2 used use VBD cord-009571-mygj2nd4 1021 3 to to TO cord-009571-mygj2nd4 1021 4 detect detect VB cord-009571-mygj2nd4 1021 5 B27 B27 NNP cord-009571-mygj2nd4 1021 6 , , , cord-009571-mygj2nd4 1021 7 B7 b7 NN cord-009571-mygj2nd4 1021 8 , , , cord-009571-mygj2nd4 1021 9 and and CC cord-009571-mygj2nd4 1021 10 Bw22 Bw22 NNP cord-009571-mygj2nd4 1021 11 were be VBD cord-009571-mygj2nd4 1021 12 free free JJ cord-009571-mygj2nd4 1021 13 of of IN cord-009571-mygj2nd4 1021 14 noteworthy noteworthy JJ cord-009571-mygj2nd4 1021 15 cross cross NN cord-009571-mygj2nd4 1021 16 - - NN cord-009571-mygj2nd4 1021 17 reactivity reactivity NN cord-009571-mygj2nd4 1021 18 . . . cord-009571-mygj2nd4 1022 1 Duration duration NN cord-009571-mygj2nd4 1022 2 of of IN cord-009571-mygj2nd4 1022 3 disease disease NN cord-009571-mygj2nd4 1022 4 , , , cord-009571-mygj2nd4 1022 5 age age NN cord-009571-mygj2nd4 1022 6 at at IN cord-009571-mygj2nd4 1022 7 onset onset NN cord-009571-mygj2nd4 1022 8 of of IN cord-009571-mygj2nd4 1022 9 AS AS NNP cord-009571-mygj2nd4 1022 10 , , , cord-009571-mygj2nd4 1022 11 skeletal skeletal JJ cord-009571-mygj2nd4 1022 12 manifestations manifestation NNS cord-009571-mygj2nd4 1022 13 , , , cord-009571-mygj2nd4 1022 14 prevalence prevalence NN cord-009571-mygj2nd4 1022 15 of of IN cord-009571-mygj2nd4 1022 16 acute acute JJ cord-009571-mygj2nd4 1022 17 anterior anterior JJ cord-009571-mygj2nd4 1022 18 uveitis uveitis NN cord-009571-mygj2nd4 1022 19 and and CC cord-009571-mygj2nd4 1022 20 frequency frequency NN cord-009571-mygj2nd4 1022 21 of of IN cord-009571-mygj2nd4 1022 22 a a DT cord-009571-mygj2nd4 1022 23 positive positive JJ cord-009571-mygj2nd4 1022 24 family family NN cord-009571-mygj2nd4 1022 25 history history NN cord-009571-mygj2nd4 1022 26 for for IN cord-009571-mygj2nd4 1022 27 AS AS NNP cord-009571-mygj2nd4 1022 28 were be VBD cord-009571-mygj2nd4 1022 29 compared compare VBN cord-009571-mygj2nd4 1022 30 between between IN cord-009571-mygj2nd4 1022 31 the the DT cord-009571-mygj2nd4 1022 32 10 10 CD cord-009571-mygj2nd4 1022 33 B7-positive B7-positive . cord-009571-mygj2nd4 1022 34 ( ( -LRB- cord-009571-mygj2nd4 1022 35 Gp Gp NNP cord-009571-mygj2nd4 1022 36 - - HYPH cord-009571-mygj2nd4 1022 37 I I NNP cord-009571-mygj2nd4 1022 38 ) ) -RRB- cord-009571-mygj2nd4 1022 39 and and CC cord-009571-mygj2nd4 1022 40 the the DT cord-009571-mygj2nd4 1022 41 16 16 CD cord-009571-mygj2nd4 1022 42 B27-positive B27-positive NNP cord-009571-mygj2nd4 1022 43 ( ( -LRB- cord-009571-mygj2nd4 1022 44 Gp-11 Gp-11 NNP cord-009571-mygj2nd4 1022 45 ) ) -RRB- cord-009571-mygj2nd4 1022 46 patients patient NNS cord-009571-mygj2nd4 1022 47 . . . cord-009571-mygj2nd4 1023 1 Duration duration NN cord-009571-mygj2nd4 1023 2 of of IN cord-009571-mygj2nd4 1023 3 disease disease NN cord-009571-mygj2nd4 1023 4 at at IN cord-009571-mygj2nd4 1023 5 the the DT cord-009571-mygj2nd4 1023 6 time time NN cord-009571-mygj2nd4 1023 7 of of IN cord-009571-mygj2nd4 1023 8 study study NN cord-009571-mygj2nd4 1023 9 was be VBD cord-009571-mygj2nd4 1023 10 not not RB cord-009571-mygj2nd4 1023 11 significantly significantly RB cord-009571-mygj2nd4 1023 12 different different JJ cord-009571-mygj2nd4 1023 13 in in IN cord-009571-mygj2nd4 1023 14 the the DT cord-009571-mygj2nd4 1023 15 two two CD cord-009571-mygj2nd4 1023 16 groups group NNS cord-009571-mygj2nd4 1023 17 . . . cord-009571-mygj2nd4 1024 1 However however RB cord-009571-mygj2nd4 1024 2 , , , cord-009571-mygj2nd4 1024 3 mean mean VB cord-009571-mygj2nd4 1024 4 age age NN cord-009571-mygj2nd4 1024 5 at at IN cord-009571-mygj2nd4 1024 6 onset onset NN cord-009571-mygj2nd4 1024 7 of of IN cord-009571-mygj2nd4 1024 8 AS AS NNP cord-009571-mygj2nd4 1024 9 differed differ VBN cord-009571-mygj2nd4 1024 10 significantly significantly RB cord-009571-mygj2nd4 1024 11 : : : cord-009571-mygj2nd4 1024 12 33.6 33.6 CD cord-009571-mygj2nd4 1024 13 years year NNS cord-009571-mygj2nd4 1024 14 in in IN cord-009571-mygj2nd4 1024 15 Gp Gp NNP cord-009571-mygj2nd4 1024 16 - - HYPH cord-009571-mygj2nd4 1024 17 I I NNP cord-009571-mygj2nd4 1024 18 and and CC cord-009571-mygj2nd4 1024 19 22.2 22.2 CD cord-009571-mygj2nd4 1024 20 years year NNS cord-009571-mygj2nd4 1024 21 in in IN cord-009571-mygj2nd4 1024 22 Gp Gp NNP cord-009571-mygj2nd4 1024 23 - - HYPH cord-009571-mygj2nd4 1024 24 I1 i1 NN cord-009571-mygj2nd4 1024 25 ( ( -LRB- cord-009571-mygj2nd4 1024 26 P p NN cord-009571-mygj2nd4 1024 27 < < XX cord-009571-mygj2nd4 1024 28 0.005 0.005 CD cord-009571-mygj2nd4 1024 29 ) ) -RRB- cord-009571-mygj2nd4 1024 30 . . . cord-009571-mygj2nd4 1025 1 Skeletal skeletal JJ cord-009571-mygj2nd4 1025 2 manifestations manifestation NNS cord-009571-mygj2nd4 1025 3 of of IN cord-009571-mygj2nd4 1025 4 the the DT cord-009571-mygj2nd4 1025 5 disease disease NN cord-009571-mygj2nd4 1025 6 did do VBD cord-009571-mygj2nd4 1025 7 not not RB cord-009571-mygj2nd4 1025 8 differ differ VB cord-009571-mygj2nd4 1025 9 significantly significantly RB cord-009571-mygj2nd4 1025 10 in in IN cord-009571-mygj2nd4 1025 11 these these DT cord-009571-mygj2nd4 1025 12 groups group NNS cord-009571-mygj2nd4 1025 13 . . . cord-009571-mygj2nd4 1026 1 Uveitis Uveitis NNP cord-009571-mygj2nd4 1026 2 occurred occur VBD cord-009571-mygj2nd4 1026 3 in in IN cord-009571-mygj2nd4 1026 4 2 2 CD cord-009571-mygj2nd4 1026 5 patients patient NNS cord-009571-mygj2nd4 1026 6 ( ( -LRB- cord-009571-mygj2nd4 1026 7 20 20 CD cord-009571-mygj2nd4 1026 8 % % NN cord-009571-mygj2nd4 1026 9 ) ) -RRB- cord-009571-mygj2nd4 1026 10 in in IN cord-009571-mygj2nd4 1026 11 Gp Gp NNP cord-009571-mygj2nd4 1026 12 - - HYPH cord-009571-mygj2nd4 1026 13 I I NNP cord-009571-mygj2nd4 1026 14 and and CC cord-009571-mygj2nd4 1026 15 8 8 CD cord-009571-mygj2nd4 1026 16 patients patient NNS cord-009571-mygj2nd4 1026 17 ( ( -LRB- cord-009571-mygj2nd4 1026 18 50 50 CD cord-009571-mygj2nd4 1026 19 % % NN cord-009571-mygj2nd4 1026 20 ) ) -RRB- cord-009571-mygj2nd4 1026 21 in in IN cord-009571-mygj2nd4 1026 22 Gp Gp NNP cord-009571-mygj2nd4 1026 23 - - HYPH cord-009571-mygj2nd4 1026 24 I1 i1 NN cord-009571-mygj2nd4 1026 25 ( ( -LRB- cord-009571-mygj2nd4 1026 26 P p NN cord-009571-mygj2nd4 1026 27 = = SYM cord-009571-mygj2nd4 1026 28 0.158 0.158 CD cord-009571-mygj2nd4 1026 29 ) ) -RRB- cord-009571-mygj2nd4 1026 30 . . . cord-009571-mygj2nd4 1027 1 A a DT cord-009571-mygj2nd4 1027 2 family family NN cord-009571-mygj2nd4 1027 3 history history NN cord-009571-mygj2nd4 1027 4 of of IN cord-009571-mygj2nd4 1027 5 AS AS NNP cord-009571-mygj2nd4 1027 6 could could MD cord-009571-mygj2nd4 1027 7 be be VB cord-009571-mygj2nd4 1027 8 obtained obtain VBN cord-009571-mygj2nd4 1027 9 in in IN cord-009571-mygj2nd4 1027 10 none none NN cord-009571-mygj2nd4 1027 11 of of IN cord-009571-mygj2nd4 1027 12 Gp Gp NNP cord-009571-mygj2nd4 1027 13 - - HYPH cord-009571-mygj2nd4 1027 14 I -PRON- PRP cord-009571-mygj2nd4 1027 15 patients patient NNS cord-009571-mygj2nd4 1027 16 and and CC cord-009571-mygj2nd4 1027 17 6 6 CD cord-009571-mygj2nd4 1027 18 ( ( -LRB- cord-009571-mygj2nd4 1027 19 37.5 37.5 CD cord-009571-mygj2nd4 1027 20 % % NN cord-009571-mygj2nd4 1027 21 ) ) -RRB- cord-009571-mygj2nd4 1027 22 of of IN cord-009571-mygj2nd4 1027 23 the the DT cord-009571-mygj2nd4 1027 24 Gp Gp NNP cord-009571-mygj2nd4 1027 25 - - HYPH cord-009571-mygj2nd4 1027 26 I1 i1 NN cord-009571-mygj2nd4 1027 27 patients patient NNS cord-009571-mygj2nd4 1027 28 ( ( -LRB- cord-009571-mygj2nd4 1027 29 P p NN cord-009571-mygj2nd4 1027 30 = = SYM cord-009571-mygj2nd4 1027 31 0.034 0.034 CD cord-009571-mygj2nd4 1027 32 , , , cord-009571-mygj2nd4 1027 33 using use VBG cord-009571-mygj2nd4 1027 34 Fisher Fisher NNP cord-009571-mygj2nd4 1027 35 's 's POS cord-009571-mygj2nd4 1027 36 exact exact JJ cord-009571-mygj2nd4 1027 37 test test NN cord-009571-mygj2nd4 1027 38 ) ) -RRB- cord-009571-mygj2nd4 1027 39 . . . cord-009571-mygj2nd4 1028 1 These these DT cord-009571-mygj2nd4 1028 2 data datum NNS cord-009571-mygj2nd4 1028 3 indicate indicate VBP cord-009571-mygj2nd4 1028 4 that that IN cord-009571-mygj2nd4 1028 5 HLA HLA NNP cord-009571-mygj2nd4 1028 6 - - HYPH cord-009571-mygj2nd4 1028 7 B7 B7 NNP cord-009571-mygj2nd4 1028 8 may may MD cord-009571-mygj2nd4 1028 9 be be VB cord-009571-mygj2nd4 1028 10 associated associate VBN cord-009571-mygj2nd4 1028 11 with with IN cord-009571-mygj2nd4 1028 12 the the DT cord-009571-mygj2nd4 1028 13 development development NN cord-009571-mygj2nd4 1028 14 of of IN cord-009571-mygj2nd4 1028 15 AS AS NNP cord-009571-mygj2nd4 1028 16 in in IN cord-009571-mygj2nd4 1028 17 the the DT cord-009571-mygj2nd4 1028 18 B27-negative B27-negative NNP cord-009571-mygj2nd4 1028 19 Black black JJ cord-009571-mygj2nd4 1028 20 popu popu NN cord-009571-mygj2nd4 1028 21 - - HYPH cord-009571-mygj2nd4 1028 22 lation lation NN cord-009571-mygj2nd4 1028 23 . . . cord-009571-mygj2nd4 1029 1 The the DT cord-009571-mygj2nd4 1029 2 B7-positive B7-positive NNP cord-009571-mygj2nd4 1029 3 Black Black NNP cord-009571-mygj2nd4 1029 4 AS as IN cord-009571-mygj2nd4 1029 5 patients patient NNS cord-009571-mygj2nd4 1029 6 are be VBP cord-009571-mygj2nd4 1029 7 older old JJR cord-009571-mygj2nd4 1029 8 at at IN cord-009571-mygj2nd4 1029 9 onset onset NN cord-009571-mygj2nd4 1029 10 of of IN cord-009571-mygj2nd4 1029 11 their -PRON- PRP$ cord-009571-mygj2nd4 1029 12 disease disease NN cord-009571-mygj2nd4 1029 13 than than IN cord-009571-mygj2nd4 1029 14 the the DT cord-009571-mygj2nd4 1029 15 B27-positive b27-positive JJ cord-009571-mygj2nd4 1029 16 patients patient NNS cord-009571-mygj2nd4 1029 17 and and CC cord-009571-mygj2nd4 1029 18 tend tend VBP cord-009571-mygj2nd4 1029 19 to to TO cord-009571-mygj2nd4 1029 20 lack lack VB cord-009571-mygj2nd4 1029 21 obvious obvious JJ cord-009571-mygj2nd4 1029 22 familial familial JJ cord-009571-mygj2nd4 1029 23 aggregation aggregation NN cord-009571-mygj2nd4 1029 24 of of IN cord-009571-mygj2nd4 1029 25 the the DT cord-009571-mygj2nd4 1029 26 disease disease NN cord-009571-mygj2nd4 1029 27 . . . cord-009571-mygj2nd4 1030 1 The the DT cord-009571-mygj2nd4 1030 2 findings finding NNS cord-009571-mygj2nd4 1030 3 suggest suggest VBP cord-009571-mygj2nd4 1030 4 that that IN cord-009571-mygj2nd4 1030 5 American American NNP cord-009571-mygj2nd4 1030 6 Black Black NNP cord-009571-mygj2nd4 1030 7 AS as IN cord-009571-mygj2nd4 1030 8 patients patient NNS cord-009571-mygj2nd4 1030 9 lacking lack VBG cord-009571-mygj2nd4 1030 10 B27 B27 NNP cord-009571-mygj2nd4 1030 11 but but CC cord-009571-mygj2nd4 1030 12 possessing possess VBG cord-009571-mygj2nd4 1030 13 B7 b7 NN cord-009571-mygj2nd4 1030 14 represent represent VBP cord-009571-mygj2nd4 1030 15 a a DT cord-009571-mygj2nd4 1030 16 subgroup subgroup NN cord-009571-mygj2nd4 1030 17 of of IN cord-009571-mygj2nd4 1030 18 patients patient NNS cord-009571-mygj2nd4 1030 19 with with IN cord-009571-mygj2nd4 1030 20 this this DT cord-009571-mygj2nd4 1030 21 disease disease NN cord-009571-mygj2nd4 1030 22 . . . cord-009571-mygj2nd4 1031 1 Prostaglandin prostaglandin NN cord-009571-mygj2nd4 1031 2 synthesis synthesis NN cord-009571-mygj2nd4 1031 3 inhibitors inhibitor NNS cord-009571-mygj2nd4 1031 4 ( ( -LRB- cord-009571-mygj2nd4 1031 5 PGSI PGSI NNP cord-009571-mygj2nd4 1031 6 ) ) -RRB- cord-009571-mygj2nd4 1031 7 may may MD cord-009571-mygj2nd4 1031 8 affect affect VB cord-009571-mygj2nd4 1031 9 renal renal JJ cord-009571-mygj2nd4 1031 10 function function NN cord-009571-mygj2nd4 1031 11 in in IN cord-009571-mygj2nd4 1031 12 humans human NNS cord-009571-mygj2nd4 1031 13 , , , cord-009571-mygj2nd4 1031 14 especially especially RB cord-009571-mygj2nd4 1031 15 under under IN cord-009571-mygj2nd4 1031 16 conditions condition NNS cord-009571-mygj2nd4 1031 17 of of IN cord-009571-mygj2nd4 1031 18 renal renal JJ cord-009571-mygj2nd4 1031 19 injury injury NN cord-009571-mygj2nd4 1031 20 such such JJ cord-009571-mygj2nd4 1031 21 as as IN cord-009571-mygj2nd4 1031 22 lupus lupus NN cord-009571-mygj2nd4 1031 23 nephritis nephritis NN cord-009571-mygj2nd4 1031 24 . . . cord-009571-mygj2nd4 1032 1 To to TO cord-009571-mygj2nd4 1032 2 explore explore VB cord-009571-mygj2nd4 1032 3 this this DT cord-009571-mygj2nd4 1032 4 preferential preferential JJ cord-009571-mygj2nd4 1032 5 effect effect NN cord-009571-mygj2nd4 1032 6 in in IN cord-009571-mygj2nd4 1032 7 systemic systemic JJ cord-009571-mygj2nd4 1032 8 lupus lupus NN cord-009571-mygj2nd4 1032 9 erythematosus erythematosus NN cord-009571-mygj2nd4 1032 10 ( ( -LRB- cord-009571-mygj2nd4 1032 11 SLE SLE NNP cord-009571-mygj2nd4 1032 12 ) ) -RRB- cord-009571-mygj2nd4 1032 13 , , , cord-009571-mygj2nd4 1032 14 we -PRON- PRP cord-009571-mygj2nd4 1032 15 measured measure VBD cord-009571-mygj2nd4 1032 16 basal basal JJ cord-009571-mygj2nd4 1032 17 excretion excretion NN cord-009571-mygj2nd4 1032 18 of of IN cord-009571-mygj2nd4 1032 19 urinary urinary JJ cord-009571-mygj2nd4 1032 20 prostaglandin prostaglandin NN cord-009571-mygj2nd4 1032 21 E e NN cord-009571-mygj2nd4 1032 22 ( ( -LRB- cord-009571-mygj2nd4 1032 23 iPGE iPGE NNP cord-009571-mygj2nd4 1032 24 ) ) -RRB- cord-009571-mygj2nd4 1032 25 by by IN cord-009571-mygj2nd4 1032 26 radioimmunoassay radioimmunoassay JJ cord-009571-mygj2nd4 1032 27 in in IN cord-009571-mygj2nd4 1032 28 10 10 CD cord-009571-mygj2nd4 1032 29 female female JJ cord-009571-mygj2nd4 1032 30 SLE SLE NNP cord-009571-mygj2nd4 1032 31 patients patient NNS cord-009571-mygj2nd4 1032 32 and and CC cord-009571-mygj2nd4 1032 33 28 28 CD cord-009571-mygj2nd4 1032 34 normal normal JJ cord-009571-mygj2nd4 1032 35 women woman NNS cord-009571-mygj2nd4 1032 36 on on IN cord-009571-mygj2nd4 1032 37 a a DT cord-009571-mygj2nd4 1032 38 constant constant JJ cord-009571-mygj2nd4 1032 39 109 109 CD cord-009571-mygj2nd4 1032 40 mEq mEq NNS cord-009571-mygj2nd4 1032 41 sodium sodium NN cord-009571-mygj2nd4 1032 42 diet diet NN cord-009571-mygj2nd4 1032 43 . . . cord-009571-mygj2nd4 1033 1 No no DT cord-009571-mygj2nd4 1033 2 patient patient JJ cord-009571-mygj2nd4 1033 3 or or CC cord-009571-mygj2nd4 1033 4 normal normal JJ cord-009571-mygj2nd4 1033 5 control control NN cord-009571-mygj2nd4 1033 6 received receive VBD cord-009571-mygj2nd4 1033 7 nonsteroidal nonsteroidal JJ cord-009571-mygj2nd4 1033 8 antiinflammatory antiinflammatory JJ cord-009571-mygj2nd4 1033 9 drugs drug NNS cord-009571-mygj2nd4 1033 10 during during IN cord-009571-mygj2nd4 1033 11 the the DT cord-009571-mygj2nd4 1033 12 study study NN cord-009571-mygj2nd4 1033 13 period period NN cord-009571-mygj2nd4 1033 14 but but CC cord-009571-mygj2nd4 1033 15 7 7 CD cord-009571-mygj2nd4 1033 16 of of IN cord-009571-mygj2nd4 1033 17 10 10 CD cord-009571-mygj2nd4 1033 18 patients patient NNS cord-009571-mygj2nd4 1033 19 were be VBD cord-009571-mygj2nd4 1033 20 on on IN cord-009571-mygj2nd4 1033 21 maintenance maintenance NN cord-009571-mygj2nd4 1033 22 low low JJ cord-009571-mygj2nd4 1033 23 dose dose NN cord-009571-mygj2nd4 1033 24 prednisone prednisone NNP cord-009571-mygj2nd4 1034 1 ( ( -LRB- cord-009571-mygj2nd4 1034 2 I -PRON- PRP cord-009571-mygj2nd4 1034 3 20 20 CD cord-009571-mygj2nd4 1034 4 mg mg NNP cord-009571-mygj2nd4 1034 5 / / SYM cord-009571-mygj2nd4 1034 6 day day NN cord-009571-mygj2nd4 1034 7 ) ) -RRB- cord-009571-mygj2nd4 1034 8 . . . cord-009571-mygj2nd4 1035 1 Six six CD cord-009571-mygj2nd4 1035 2 of of IN cord-009571-mygj2nd4 1035 3 10 10 CD cord-009571-mygj2nd4 1035 4 patients patient NNS cord-009571-mygj2nd4 1035 5 had have VBD cord-009571-mygj2nd4 1035 6 biopsy biopsy RB cord-009571-mygj2nd4 1035 7 - - HYPH cord-009571-mygj2nd4 1035 8 proved prove VBN cord-009571-mygj2nd4 1035 9 nephritis nephritis NN cord-009571-mygj2nd4 1035 10 ; ; : cord-009571-mygj2nd4 1035 11 4 4 LS cord-009571-mygj2nd4 1035 12 had have VBD cord-009571-mygj2nd4 1035 13 insufficient insufficient JJ cord-009571-mygj2nd4 1035 14 urinary urinary JJ cord-009571-mygj2nd4 1035 15 findings finding NNS cord-009571-mygj2nd4 1035 16 to to TO cord-009571-mygj2nd4 1035 17 prompt prompt VB cord-009571-mygj2nd4 1035 18 a a DT cord-009571-mygj2nd4 1035 19 diagnostic diagnostic JJ cord-009571-mygj2nd4 1035 20 biopsy biopsy NN cord-009571-mygj2nd4 1035 21 . . . cord-009571-mygj2nd4 1036 1 All all DT cord-009571-mygj2nd4 1036 2 iPGE ipge JJ cord-009571-mygj2nd4 1036 3 values value NNS cord-009571-mygj2nd4 1036 4 were be VBD cord-009571-mygj2nd4 1036 5 determined determine VBN cord-009571-mygj2nd4 1036 6 in in IN cord-009571-mygj2nd4 1036 7 triplicate triplicate NN cord-009571-mygj2nd4 1036 8 on on RP cord-009571-mygj2nd4 1036 9 at at RB cord-009571-mygj2nd4 1036 10 least least RBS cord-009571-mygj2nd4 1036 11 three three CD cord-009571-mygj2nd4 1036 12 separate separate JJ cord-009571-mygj2nd4 1036 13 24-hour 24-hour JJ cord-009571-mygj2nd4 1036 14 collections collection NNS cord-009571-mygj2nd4 1036 15 except except IN cord-009571-mygj2nd4 1036 16 in in IN cord-009571-mygj2nd4 1036 17 one one CD cord-009571-mygj2nd4 1036 18 patient patient NN cord-009571-mygj2nd4 1036 19 with with IN cord-009571-mygj2nd4 1036 20 two two CD cord-009571-mygj2nd4 1036 21 such such JJ cord-009571-mygj2nd4 1036 22 collections collection NNS cord-009571-mygj2nd4 1036 23 . . . cord-009571-mygj2nd4 1037 1 SLE SLE NNP cord-009571-mygj2nd4 1037 2 patients patient NNS cord-009571-mygj2nd4 1037 3 had have VBD cord-009571-mygj2nd4 1037 4 a a DT cord-009571-mygj2nd4 1037 5 significantly significantly RB cord-009571-mygj2nd4 1037 6 higher high JJR cord-009571-mygj2nd4 1037 7 mean mean JJ cord-009571-mygj2nd4 1037 8 iPGE ipge JJ cord-009571-mygj2nd4 1037 9 excretion excretion NN cord-009571-mygj2nd4 1037 10 than than IN cord-009571-mygj2nd4 1037 11 normals normal NNS cord-009571-mygj2nd4 1037 12 ( ( -LRB- cord-009571-mygj2nd4 1037 13 45.8 45.8 CD cord-009571-mygj2nd4 1037 14 f f NNP cord-009571-mygj2nd4 1037 15 5.3 5.3 CD cord-009571-mygj2nd4 1037 16 versus versus IN cord-009571-mygj2nd4 1037 17 29.6 29.6 CD cord-009571-mygj2nd4 1037 18 f f NNP cord-009571-mygj2nd4 1037 19 2.2 2.2 CD cord-009571-mygj2nd4 1037 20 ng ng NN cord-009571-mygj2nd4 1037 21 / / SYM cord-009571-mygj2nd4 1037 22 hour hour NN cord-009571-mygj2nd4 1037 23 ; ; : cord-009571-mygj2nd4 1037 24 mean mean VB cord-009571-mygj2nd4 1037 25 f f NNP cord-009571-mygj2nd4 1037 26 SEM sem NN cord-009571-mygj2nd4 1037 27 ; ; : cord-009571-mygj2nd4 1037 28 P p NN cord-009571-mygj2nd4 1037 29 < < XX cord-009571-mygj2nd4 1037 30 0.005 0.005 CD cord-009571-mygj2nd4 1037 31 ) ) -RRB- cord-009571-mygj2nd4 1037 32 . . . cord-009571-mygj2nd4 1038 1 SLE SLE NNP cord-009571-mygj2nd4 1038 2 patients patient NNS cord-009571-mygj2nd4 1038 3 with with IN cord-009571-mygj2nd4 1038 4 biopsy biopsy NN cord-009571-mygj2nd4 1038 5 - - HYPH cord-009571-mygj2nd4 1038 6 proved prove VBN cord-009571-mygj2nd4 1038 7 nephritis nephritis NN cord-009571-mygj2nd4 1038 8 had have VBD cord-009571-mygj2nd4 1038 9 a a DT cord-009571-mygj2nd4 1038 10 higher high JJR cord-009571-mygj2nd4 1038 11 mean mean JJ cord-009571-mygj2nd4 1038 12 excretion excretion NN cord-009571-mygj2nd4 1038 13 than than IN cord-009571-mygj2nd4 1038 14 those those DT cord-009571-mygj2nd4 1038 15 without without IN cord-009571-mygj2nd4 1038 16 biopsy biopsy NN cord-009571-mygj2nd4 1038 17 ( ( -LRB- cord-009571-mygj2nd4 1038 18 49.7 49.7 CD cord-009571-mygj2nd4 1038 19 f f NNP cord-009571-mygj2nd4 1038 20 8.6 8.6 CD cord-009571-mygj2nd4 1038 21 versus versus IN cord-009571-mygj2nd4 1038 22 39.9 39.9 CD cord-009571-mygj2nd4 1038 23 f f NN cord-009571-mygj2nd4 1038 24 3.2 3.2 CD cord-009571-mygj2nd4 1038 25 ng ng NN cord-009571-mygj2nd4 1038 26 / / SYM cord-009571-mygj2nd4 1038 27 hour hour NN cord-009571-mygj2nd4 1038 28 ) ) -RRB- cord-009571-mygj2nd4 1039 1 although although IN cord-009571-mygj2nd4 1039 2 the the DT cord-009571-mygj2nd4 1039 3 difference difference NN cord-009571-mygj2nd4 1039 4 was be VBD cord-009571-mygj2nd4 1039 5 not not RB cord-009571-mygj2nd4 1039 6 statistically statistically RB cord-009571-mygj2nd4 1039 7 significant significant JJ cord-009571-mygj2nd4 1039 8 . . . cord-009571-mygj2nd4 1040 1 Urinary urinary JJ cord-009571-mygj2nd4 1040 2 sediment sediment NN cord-009571-mygj2nd4 1040 3 and and CC cord-009571-mygj2nd4 1040 4 general general JJ cord-009571-mygj2nd4 1040 5 disease disease NN cord-009571-mygj2nd4 1040 6 activity activity NN cord-009571-mygj2nd4 1040 7 did do VBD cord-009571-mygj2nd4 1040 8 not not RB cord-009571-mygj2nd4 1040 9 correlate correlate VB cord-009571-mygj2nd4 1040 10 with with IN cord-009571-mygj2nd4 1040 11 urinary urinary JJ cord-009571-mygj2nd4 1040 12 iPGE ipge NN cord-009571-mygj2nd4 1040 13 . . . cord-009571-mygj2nd4 1041 1 All all DT cord-009571-mygj2nd4 1041 2 10 10 CD cord-009571-mygj2nd4 1041 3 patients patient NNS cord-009571-mygj2nd4 1041 4 showed show VBD cord-009571-mygj2nd4 1041 5 a a DT cord-009571-mygj2nd4 1041 6 decrease decrease NN cord-009571-mygj2nd4 1041 7 in in IN cord-009571-mygj2nd4 1041 8 creatinine creatinine NN cord-009571-mygj2nd4 1041 9 clearance clearance NN cord-009571-mygj2nd4 1041 10 with with IN cord-009571-mygj2nd4 1041 11 PGSI PGSI NNP cord-009571-mygj2nd4 1041 12 administration administration NN cord-009571-mygj2nd4 1041 13 but but CC cord-009571-mygj2nd4 1041 14 the the DT cord-009571-mygj2nd4 1041 15 percent percent NN cord-009571-mygj2nd4 1041 16 change change NN cord-009571-mygj2nd4 1041 17 did do VBD cord-009571-mygj2nd4 1041 18 not not RB cord-009571-mygj2nd4 1041 19 correlate correlate VB cord-009571-mygj2nd4 1041 20 with with IN cord-009571-mygj2nd4 1041 21 basal basal NN cord-009571-mygj2nd4 1041 22 urinary urinary JJ cord-009571-mygj2nd4 1041 23 iPGE ipge JJ cord-009571-mygj2nd4 1041 24 excretion excretion NN cord-009571-mygj2nd4 1041 25 . . . cord-009571-mygj2nd4 1042 1 Elevated elevated JJ cord-009571-mygj2nd4 1042 2 urinary urinary JJ cord-009571-mygj2nd4 1042 3 iPGE ipge JJ cord-009571-mygj2nd4 1042 4 excretion excretion NN cord-009571-mygj2nd4 1042 5 in in IN cord-009571-mygj2nd4 1042 6 SLE SLE NNP cord-009571-mygj2nd4 1042 7 may may MD cord-009571-mygj2nd4 1042 8 reflect reflect VB cord-009571-mygj2nd4 1042 9 renal renal JJ cord-009571-mygj2nd4 1042 10 inflammation inflammation NN cord-009571-mygj2nd4 1042 11 due due IN cord-009571-mygj2nd4 1042 12 to to IN cord-009571-mygj2nd4 1042 13 immune immune JJ cord-009571-mygj2nd4 1042 14 complex complex JJ cord-009571-mygj2nd4 1042 15 nephritis nephritis NN cord-009571-mygj2nd4 1042 16 and and CC cord-009571-mygj2nd4 1042 17 may may MD cord-009571-mygj2nd4 1042 18 explain explain VB cord-009571-mygj2nd4 1042 19 the the DT cord-009571-mygj2nd4 1042 20 greater great JJR cord-009571-mygj2nd4 1042 21 sensitivity sensitivity NN cord-009571-mygj2nd4 1042 22 of of IN cord-009571-mygj2nd4 1042 23 renal renal JJ cord-009571-mygj2nd4 1042 24 autoregulation autoregulation NN cord-009571-mygj2nd4 1042 25 to to IN cord-009571-mygj2nd4 1042 26 PGSI PGSI NNP cord-009571-mygj2nd4 1042 27 in in IN cord-009571-mygj2nd4 1042 28 this this DT cord-009571-mygj2nd4 1042 29 setting setting NN cord-009571-mygj2nd4 1042 30 . . . cord-009571-mygj2nd4 1043 1 The the DT cord-009571-mygj2nd4 1043 2 therapy therapy NN cord-009571-mygj2nd4 1043 3 of of IN cord-009571-mygj2nd4 1043 4 lupus lupus NNP cord-009571-mygj2nd4 1043 5 glomerulonephritis glomerulonephritis NN cord-009571-mygj2nd4 1043 6 has have VBZ cord-009571-mygj2nd4 1043 7 been be VBN cord-009571-mygj2nd4 1043 8 evaluated evaluate VBN cord-009571-mygj2nd4 1043 9 in in IN cord-009571-mygj2nd4 1043 10 a a DT cord-009571-mygj2nd4 1043 11 randomized randomized JJ cord-009571-mygj2nd4 1043 12 study study NN cord-009571-mygj2nd4 1043 13 of of IN cord-009571-mygj2nd4 1043 14 corticosteroid corticosteroid NN cord-009571-mygj2nd4 1043 15 treated treat VBD cord-009571-mygj2nd4 1043 16 patients patient NNS cord-009571-mygj2nd4 1043 17 comparing compare VBG cord-009571-mygj2nd4 1043 18 bolus bolus NN cord-009571-mygj2nd4 1043 19 IVCy IVCy NNS cord-009571-mygj2nd4 1043 20 ( ( -LRB- cord-009571-mygj2nd4 1043 21 5.5 5.5 CD cord-009571-mygj2nd4 1043 22 - - SYM cord-009571-mygj2nd4 1043 23 26.7 26.7 CD cord-009571-mygj2nd4 1043 24 mg mg NNP cord-009571-mygj2nd4 1043 25 / / SYM cord-009571-mygj2nd4 1043 26 kg kg NNP cord-009571-mygj2nd4 1043 27 , , , cord-009571-mygj2nd4 1043 28 every every DT cord-009571-mygj2nd4 1043 29 3 3 CD cord-009571-mygj2nd4 1043 30 months month NNS cord-009571-mygj2nd4 1043 31 ) ) -RRB- cord-009571-mygj2nd4 1043 32 , , , cord-009571-mygj2nd4 1043 33 combined combine VBN cord-009571-mygj2nd4 1043 34 oral oral JJ cord-009571-mygj2nd4 1043 35 Cy Cy NNP cord-009571-mygj2nd4 1043 36 + + CC cord-009571-mygj2nd4 1043 37 Az Az NNP cord-009571-mygj2nd4 1043 38 ( ( -LRB- cord-009571-mygj2nd4 1043 39 50 50 CD cord-009571-mygj2nd4 1043 40 mg mg NN cord-009571-mygj2nd4 1043 41 of of IN cord-009571-mygj2nd4 1043 42 each each DT cord-009571-mygj2nd4 1043 43 , , , cord-009571-mygj2nd4 1043 44 daily daily RB cord-009571-mygj2nd4 1043 45 ) ) -RRB- cord-009571-mygj2nd4 1043 46 , , , cord-009571-mygj2nd4 1043 47 and and CC cord-009571-mygj2nd4 1043 48 prednisone prednisone NN cord-009571-mygj2nd4 1043 49 alone alone JJ cord-009571-mygj2nd4 1043 50 ( ( -LRB- cord-009571-mygj2nd4 1043 51 Pr Pr NNP cord-009571-mygj2nd4 1043 52 ) ) -RRB- cord-009571-mygj2nd4 1043 53 . . . cord-009571-mygj2nd4 1044 1 Five five CD cord-009571-mygj2nd4 1044 2 years year NNS cord-009571-mygj2nd4 1044 3 after after IN cord-009571-mygj2nd4 1044 4 the the DT cord-009571-mygj2nd4 1044 5 start start NN cord-009571-mygj2nd4 1044 6 of of IN cord-009571-mygj2nd4 1044 7 the the DT cord-009571-mygj2nd4 1044 8 trial trial NN cord-009571-mygj2nd4 1044 9 , , , cord-009571-mygj2nd4 1044 10 38 38 CD cord-009571-mygj2nd4 1044 11 patients patient NNS cord-009571-mygj2nd4 1044 12 have have VBP cord-009571-mygj2nd4 1044 13 been be VBN cord-009571-mygj2nd4 1044 14 randomized randomize VBN cord-009571-mygj2nd4 1044 15 : : : cord-009571-mygj2nd4 1044 16 IVCy IVCy NNS cord-009571-mygj2nd4 1044 17 ( ( -LRB- cord-009571-mygj2nd4 1044 18 12 12 CD cord-009571-mygj2nd4 1044 19 ) ) -RRB- cord-009571-mygj2nd4 1044 20 , , , cord-009571-mygj2nd4 1044 21 Cy Cy NNP cord-009571-mygj2nd4 1044 22 + + CC cord-009571-mygj2nd4 1044 23 Az Az NNP cord-009571-mygj2nd4 1044 24 ( ( -LRB- cord-009571-mygj2nd4 1044 25 14 14 CD cord-009571-mygj2nd4 1044 26 ) ) -RRB- cord-009571-mygj2nd4 1044 27 , , , cord-009571-mygj2nd4 1044 28 and and CC cord-009571-mygj2nd4 1044 29 Pr Pr NNP cord-009571-mygj2nd4 1044 30 ( ( -LRB- cord-009571-mygj2nd4 1044 31 12 12 CD cord-009571-mygj2nd4 1044 32 ) ) -RRB- cord-009571-mygj2nd4 1044 33 . . . cord-009571-mygj2nd4 1045 1 Renal renal JJ cord-009571-mygj2nd4 1045 2 involvement involvement NN cord-009571-mygj2nd4 1045 3 at at IN cord-009571-mygj2nd4 1045 4 study study NN cord-009571-mygj2nd4 1045 5 entry entry NN cord-009571-mygj2nd4 1045 6 has have VBZ cord-009571-mygj2nd4 1045 7 been be VBN cord-009571-mygj2nd4 1045 8 characterized characterize VBN cord-009571-mygj2nd4 1045 9 by by IN cord-009571-mygj2nd4 1045 10 urine urine NN cord-009571-mygj2nd4 1045 11 sediment sediment NN cord-009571-mygj2nd4 1045 12 abnormalities abnormality NNS cord-009571-mygj2nd4 1045 13 ( ( -LRB- cord-009571-mygj2nd4 1045 14 38 38 CD cord-009571-mygj2nd4 1045 15 ) ) -RRB- cord-009571-mygj2nd4 1045 16 , , , cord-009571-mygj2nd4 1045 17 impaired impair VBN cord-009571-mygj2nd4 1045 18 function function NN cord-009571-mygj2nd4 1045 19 ( ( -LRB- cord-009571-mygj2nd4 1045 20 CrCI crci XX cord-009571-mygj2nd4 1045 21 < < XX cord-009571-mygj2nd4 1045 22 100 100 CD cord-009571-mygj2nd4 1045 23 ml ml NN cord-009571-mygj2nd4 1045 24 / / SYM cord-009571-mygj2nd4 1045 25 min min NN cord-009571-mygj2nd4 1045 26 ) ) -RRB- cord-009571-mygj2nd4 1045 27 ( ( -LRB- cord-009571-mygj2nd4 1045 28 33 33 CD cord-009571-mygj2nd4 1045 29 ) ) -RRB- cord-009571-mygj2nd4 1045 30 , , , cord-009571-mygj2nd4 1045 31 nephrotic nephrotic JJ cord-009571-mygj2nd4 1045 32 proteinuria proteinuria NN cord-009571-mygj2nd4 1045 33 ( ( -LRB- cord-009571-mygj2nd4 1045 34 lo lo NNP cord-009571-mygj2nd4 1045 35 ) ) -RRB- cord-009571-mygj2nd4 1045 36 , , , cord-009571-mygj2nd4 1045 37 glomerular glomerular JJ cord-009571-mygj2nd4 1045 38 proliferation proliferation NN cord-009571-mygj2nd4 1045 39 on on IN cord-009571-mygj2nd4 1045 40 biopsy biopsy NN cord-009571-mygj2nd4 1045 41 ( ( -LRB- cord-009571-mygj2nd4 1045 42 31 31 CD cord-009571-mygj2nd4 1045 43 ) ) -RRB- cord-009571-mygj2nd4 1045 44 , , , cord-009571-mygj2nd4 1045 45 and and CC cord-009571-mygj2nd4 1045 46 an an DT cord-009571-mygj2nd4 1045 47 estimated estimate VBN cord-009571-mygj2nd4 1045 48 disease disease NN cord-009571-mygj2nd4 1045 49 duration duration NN cord-009571-mygj2nd4 1045 50 of of IN cord-009571-mygj2nd4 1045 51 less less JJR cord-009571-mygj2nd4 1045 52 than than IN cord-009571-mygj2nd4 1045 53 one one CD cord-009571-mygj2nd4 1045 54 year year NN cord-009571-mygj2nd4 1045 55 ( ( -LRB- cord-009571-mygj2nd4 1045 56 25 25 CD cord-009571-mygj2nd4 1045 57 ) ) -RRB- cord-009571-mygj2nd4 1045 58 . . . cord-009571-mygj2nd4 1046 1 The the DT cord-009571-mygj2nd4 1046 2 assigned assign VBN cord-009571-mygj2nd4 1046 3 drugs drug NNS cord-009571-mygj2nd4 1046 4 have have VBP cord-009571-mygj2nd4 1046 5 been be VBN cord-009571-mygj2nd4 1046 6 continued continue VBN cord-009571-mygj2nd4 1046 7 without without IN cord-009571-mygj2nd4 1046 8 complications complication NNS cord-009571-mygj2nd4 1046 9 in in IN cord-009571-mygj2nd4 1046 10 31 31 CD cord-009571-mygj2nd4 1046 11 patients patient NNS cord-009571-mygj2nd4 1046 12 with with IN cord-009571-mygj2nd4 1046 13 a a DT cord-009571-mygj2nd4 1046 14 median median JJ cord-009571-mygj2nd4 1046 15 course course NN cord-009571-mygj2nd4 1046 16 of of IN cord-009571-mygj2nd4 1046 17 16 16 CD cord-009571-mygj2nd4 1046 18 months month NNS cord-009571-mygj2nd4 1046 19 . . . cord-009571-mygj2nd4 1047 1 Toxicity toxicity NN cord-009571-mygj2nd4 1047 2 has have VBZ cord-009571-mygj2nd4 1047 3 necessitated necessitate VBN cord-009571-mygj2nd4 1047 4 discontinuation discontinuation NN cord-009571-mygj2nd4 1047 5 of of IN cord-009571-mygj2nd4 1047 6 the the DT cord-009571-mygj2nd4 1047 7 drugs drug NNS cord-009571-mygj2nd4 1047 8 in in IN cord-009571-mygj2nd4 1047 9 4 4 CD cord-009571-mygj2nd4 1047 10 courses course NNS cord-009571-mygj2nd4 1047 11 ; ; : cord-009571-mygj2nd4 1047 12 3 3 CD cord-009571-mygj2nd4 1047 13 Cy Cy NNP cord-009571-mygj2nd4 1047 14 + + CC cord-009571-mygj2nd4 1047 15 Az Az NNP cord-009571-mygj2nd4 1047 16 ( ( -LRB- cord-009571-mygj2nd4 1047 17 pulmonary pulmonary JJ cord-009571-mygj2nd4 1047 18 infection infection NN cord-009571-mygj2nd4 1047 19 , , , cord-009571-mygj2nd4 1047 20 hemorrhagic hemorrhagic JJ cord-009571-mygj2nd4 1047 21 cystitis cystitis NN cord-009571-mygj2nd4 1047 22 , , , cord-009571-mygj2nd4 1047 23 amenorrhea amenorrhea NN cord-009571-mygj2nd4 1047 24 ) ) -RRB- cord-009571-mygj2nd4 1047 25 and and CC cord-009571-mygj2nd4 1047 26 1 1 CD cord-009571-mygj2nd4 1047 27 IVCy IVCy NNS cord-009571-mygj2nd4 1047 28 ( ( -LRB- cord-009571-mygj2nd4 1047 29 hepatitis hepatitis NNP cord-009571-mygj2nd4 1047 30 ) ) -RRB- cord-009571-mygj2nd4 1047 31 . . . cord-009571-mygj2nd4 1048 1 Death death NN cord-009571-mygj2nd4 1048 2 has have VBZ cord-009571-mygj2nd4 1048 3 occurred occur VBN cord-009571-mygj2nd4 1048 4 in in IN cord-009571-mygj2nd4 1048 5 3 3 CD cord-009571-mygj2nd4 1048 6 patients patient NNS cord-009571-mygj2nd4 1048 7 ; ; : cord-009571-mygj2nd4 1048 8 2 2 CD cord-009571-mygj2nd4 1048 9 IVCy IVCy NNS cord-009571-mygj2nd4 1048 10 ( ( -LRB- cord-009571-mygj2nd4 1048 11 epiglottitis epiglottitis RB cord-009571-mygj2nd4 1048 12 , , , cord-009571-mygj2nd4 1048 13 sudden sudden JJ cord-009571-mygj2nd4 1048 14 death death NN cord-009571-mygj2nd4 1048 15 ) ) -RRB- cord-009571-mygj2nd4 1048 16 , , , cord-009571-mygj2nd4 1048 17 and and CC cord-009571-mygj2nd4 1048 18 1 1 CD cord-009571-mygj2nd4 1048 19 Pr pr NN cord-009571-mygj2nd4 1048 20 ( ( -LRB- cord-009571-mygj2nd4 1048 21 pulmonary pulmonary JJ cord-009571-mygj2nd4 1048 22 embolism embolism NN cord-009571-mygj2nd4 1048 23 ) ) -RRB- cord-009571-mygj2nd4 1048 24 . . . cord-009571-mygj2nd4 1049 1 The the DT cord-009571-mygj2nd4 1049 2 changes change NNS cord-009571-mygj2nd4 1049 3 of of IN cord-009571-mygj2nd4 1049 4 renal renal JJ cord-009571-mygj2nd4 1049 5 function function NN cord-009571-mygj2nd4 1049 6 of of IN cord-009571-mygj2nd4 1049 7 the the DT cord-009571-mygj2nd4 1049 8 25 25 CD cord-009571-mygj2nd4 1049 9 patients patient NNS cord-009571-mygj2nd4 1049 10 receiving receive VBG cord-009571-mygj2nd4 1049 11 a a DT cord-009571-mygj2nd4 1049 12 minimum minimum NN cord-009571-mygj2nd4 1049 13 of of IN cord-009571-mygj2nd4 1049 14 6 6 CD cord-009571-mygj2nd4 1049 15 months month NNS cord-009571-mygj2nd4 1049 16 of of IN cord-009571-mygj2nd4 1049 17 continuous continuous JJ cord-009571-mygj2nd4 1049 18 therapy therapy NN cord-009571-mygj2nd4 1049 19 have have VBP cord-009571-mygj2nd4 1049 20 been be VBN cord-009571-mygj2nd4 1049 21 assessed assess VBN cord-009571-mygj2nd4 1049 22 by by IN cord-009571-mygj2nd4 1049 23 evaluating evaluate VBG cord-009571-mygj2nd4 1049 24 the the DT cord-009571-mygj2nd4 1049 25 number number NN cord-009571-mygj2nd4 1049 26 of of IN cord-009571-mygj2nd4 1049 27 patients patient NNS cord-009571-mygj2nd4 1049 28 demonstrating demonstrate VBG cord-009571-mygj2nd4 1049 29 a a DT cord-009571-mygj2nd4 1049 30 reduction reduction NN cord-009571-mygj2nd4 1049 31 of of IN cord-009571-mygj2nd4 1049 32 function function NN cord-009571-mygj2nd4 1049 33 ( ( -LRB- cord-009571-mygj2nd4 1049 34 CrCI CrCI NNP cord-009571-mygj2nd4 1049 35 ) ) -RRB- cord-009571-mygj2nd4 1049 36 by by IN cord-009571-mygj2nd4 1049 37 at at RB cord-009571-mygj2nd4 1049 38 least least RBS cord-009571-mygj2nd4 1049 39 10 10 CD cord-009571-mygj2nd4 1049 40 % % NN cord-009571-mygj2nd4 1049 41 ( ( -LRB- cord-009571-mygj2nd4 1049 42 AlO AlO NNP cord-009571-mygj2nd4 1049 43 ) ) -RRB- cord-009571-mygj2nd4 1049 44 or or CC cord-009571-mygj2nd4 1049 45 25 25 CD cord-009571-mygj2nd4 1049 46 % % NN cord-009571-mygj2nd4 1049 47 ( ( -LRB- cord-009571-mygj2nd4 1049 48 A25 A25 NNP cord-009571-mygj2nd4 1049 49 ) ) -RRB- cord-009571-mygj2nd4 1049 50 from from IN cord-009571-mygj2nd4 1049 51 baseline baseline JJ cord-009571-mygj2nd4 1049 52 determinations determination NNS cord-009571-mygj2nd4 1049 53 at at IN cord-009571-mygj2nd4 1049 54 study study NN cord-009571-mygj2nd4 1049 55 entry entry NN cord-009571-mygj2nd4 1049 56 . . . cord-009571-mygj2nd4 1050 1 This this DT cord-009571-mygj2nd4 1050 2 interim interim JJ cord-009571-mygj2nd4 1050 3 analysis analysis NN cord-009571-mygj2nd4 1050 4 of of IN cord-009571-mygj2nd4 1050 5 an an DT cord-009571-mygj2nd4 1050 6 ongoing ongoing JJ cord-009571-mygj2nd4 1050 7 trial trial NN cord-009571-mygj2nd4 1050 8 is be VBZ cord-009571-mygj2nd4 1050 9 encouraging encouraging JJ cord-009571-mygj2nd4 1050 10 and and CC cord-009571-mygj2nd4 1050 11 suggests suggest VBZ cord-009571-mygj2nd4 1050 12 that that IN cord-009571-mygj2nd4 1050 13 IVCy IVCy NNS cord-009571-mygj2nd4 1050 14 and and CC cord-009571-mygj2nd4 1050 15 Cy Cy NNP cord-009571-mygj2nd4 1050 16 + + CC cord-009571-mygj2nd4 1050 17 Az Az NNP cord-009571-mygj2nd4 1050 18 may may MD cord-009571-mygj2nd4 1050 19 be be VB cord-009571-mygj2nd4 1050 20 more more RBR cord-009571-mygj2nd4 1050 21 effective effective JJ cord-009571-mygj2nd4 1050 22 than than IN cord-009571-mygj2nd4 1050 23 Pr Pr NNP cord-009571-mygj2nd4 1050 24 in in IN cord-009571-mygj2nd4 1050 25 the the DT cord-009571-mygj2nd4 1050 26 maintenance maintenance NN cord-009571-mygj2nd4 1050 27 of of IN cord-009571-mygj2nd4 1050 28 renal renal JJ cord-009571-mygj2nd4 1050 29 function function NN cord-009571-mygj2nd4 1050 30 of of IN cord-009571-mygj2nd4 1050 31 patients patient NNS cord-009571-mygj2nd4 1050 32 with with IN cord-009571-mygj2nd4 1050 33 lupus lupus NN cord-009571-mygj2nd4 1050 34 glomerulonephritis glomerulonephritis NN cord-009571-mygj2nd4 1050 35 . . . cord-009571-mygj2nd4 1051 1 Extended extend VBN cord-009571-mygj2nd4 1051 2 follow follow NN cord-009571-mygj2nd4 1051 3 - - HYPH cord-009571-mygj2nd4 1051 4 up up NN cord-009571-mygj2nd4 1051 5 will will MD cord-009571-mygj2nd4 1051 6 be be VB cord-009571-mygj2nd4 1051 7 required require VBN cord-009571-mygj2nd4 1051 8 to to TO cord-009571-mygj2nd4 1051 9 determine determine VB cord-009571-mygj2nd4 1051 10 the the DT cord-009571-mygj2nd4 1051 11 duration duration NN cord-009571-mygj2nd4 1051 12 of of IN cord-009571-mygj2nd4 1051 13 these these DT cord-009571-mygj2nd4 1051 14 effects effect NNS cord-009571-mygj2nd4 1051 15 and and CC cord-009571-mygj2nd4 1051 16 the the DT cord-009571-mygj2nd4 1051 17 development development NN cord-009571-mygj2nd4 1051 18 of of IN cord-009571-mygj2nd4 1051 19 drug drug NN cord-009571-mygj2nd4 1051 20 related relate VBN cord-009571-mygj2nd4 1051 21 complications complication NNS cord-009571-mygj2nd4 1051 22 . . . cord-009571-mygj2nd4 1052 1 The the DT cord-009571-mygj2nd4 1052 2 mechanism(s mechanism(s NNP cord-009571-mygj2nd4 1052 3 ) ) -RRB- cord-009571-mygj2nd4 1052 4 underlying underlie VBG cord-009571-mygj2nd4 1052 5 the the DT cord-009571-mygj2nd4 1052 6 destruction destruction NN cord-009571-mygj2nd4 1052 7 of of IN cord-009571-mygj2nd4 1052 8 bone bone NN cord-009571-mygj2nd4 1052 9 observed observe VBN cord-009571-mygj2nd4 1052 10 in in IN cord-009571-mygj2nd4 1052 11 chronic chronic JJ cord-009571-mygj2nd4 1052 12 inflammatory inflammatory JJ cord-009571-mygj2nd4 1052 13 diseases disease NNS cord-009571-mygj2nd4 1052 14 such such JJ cord-009571-mygj2nd4 1052 15 as as IN cord-009571-mygj2nd4 1052 16 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 1052 17 arthritis arthritis NN cord-009571-mygj2nd4 1052 18 or or CC cord-009571-mygj2nd4 1052 19 osteomyelitis osteomyelitis NN cord-009571-mygj2nd4 1052 20 remain(s remain(s NNP cord-009571-mygj2nd4 1052 21 ) ) -RRB- cord-009571-mygj2nd4 1052 22 to to TO cord-009571-mygj2nd4 1052 23 be be VB cord-009571-mygj2nd4 1052 24 elucidated elucidate VBN cord-009571-mygj2nd4 1052 25 . . . cord-009571-mygj2nd4 1053 1 Soluble soluble JJ cord-009571-mygj2nd4 1053 2 mediators mediator NNS cord-009571-mygj2nd4 1053 3 derived derive VBN cord-009571-mygj2nd4 1053 4 from from IN cord-009571-mygj2nd4 1053 5 immunologically immunologically RB cord-009571-mygj2nd4 1053 6 activated activate VBN cord-009571-mygj2nd4 1053 7 cells cell NNS cord-009571-mygj2nd4 1053 8 may may MD cord-009571-mygj2nd4 1053 9 play play VB cord-009571-mygj2nd4 1053 10 an an DT cord-009571-mygj2nd4 1053 11 important important JJ cord-009571-mygj2nd4 1053 12 role role NN cord-009571-mygj2nd4 1053 13 in in IN cord-009571-mygj2nd4 1053 14 such such JJ cord-009571-mygj2nd4 1053 15 phenomena phenomenon NNS cord-009571-mygj2nd4 1053 16 . . . cord-009571-mygj2nd4 1054 1 We -PRON- PRP cord-009571-mygj2nd4 1054 2 have have VBP cord-009571-mygj2nd4 1054 3 observed observe VBN cord-009571-mygj2nd4 1054 4 that that IN cord-009571-mygj2nd4 1054 5 alloantigen alloantigen NN cord-009571-mygj2nd4 1054 6 - - HYPH cord-009571-mygj2nd4 1054 7 stimulated stimulate VBN cord-009571-mygj2nd4 1054 8 human human JJ cord-009571-mygj2nd4 1054 9 mononuclear mononuclear JJ cord-009571-mygj2nd4 1054 10 leukocytes leukocyte NNS cord-009571-mygj2nd4 1054 11 ( ( -LRB- cord-009571-mygj2nd4 1054 12 MNL MNL NNP cord-009571-mygj2nd4 1054 13 ) ) -RRB- cord-009571-mygj2nd4 1054 14 release release VB cord-009571-mygj2nd4 1054 15 a a DT cord-009571-mygj2nd4 1054 16 factor(s factor(s NNP cord-009571-mygj2nd4 1054 17 ) ) -RRB- cord-009571-mygj2nd4 1054 18 capable capable JJ cord-009571-mygj2nd4 1054 19 of of IN cord-009571-mygj2nd4 1054 20 resorbing resorb VBG cord-009571-mygj2nd4 1054 21 fetal fetal JJ cord-009571-mygj2nd4 1054 22 rat rat NN cord-009571-mygj2nd4 1054 23 bones bone NNS cord-009571-mygj2nd4 1054 24 in in IN cord-009571-mygj2nd4 1054 25 vitro vitro FW cord-009571-mygj2nd4 1054 26 . . . cord-009571-mygj2nd4 1055 1 We -PRON- PRP cord-009571-mygj2nd4 1055 2 have have VBP cord-009571-mygj2nd4 1055 3 investigated investigate VBN cord-009571-mygj2nd4 1055 4 procedures procedure NNS cord-009571-mygj2nd4 1055 5 for for IN cord-009571-mygj2nd4 1055 6 the the DT cord-009571-mygj2nd4 1055 7 large large JJ cord-009571-mygj2nd4 1055 8 - - HYPH cord-009571-mygj2nd4 1055 9 scale scale NN cord-009571-mygj2nd4 1055 10 generation generation NN cord-009571-mygj2nd4 1055 11 and and CC cord-009571-mygj2nd4 1055 12 partial partial JJ cord-009571-mygj2nd4 1055 13 characterization characterization NN cord-009571-mygj2nd4 1055 14 of of IN cord-009571-mygj2nd4 1055 15 this this DT cord-009571-mygj2nd4 1055 16 bone bone NN cord-009571-mygj2nd4 1055 17 resorbing resorb VBG cord-009571-mygj2nd4 1055 18 factor(s factor(s NNP cord-009571-mygj2nd4 1055 19 ) ) -RRB- cord-009571-mygj2nd4 1055 20 . . . cord-009571-mygj2nd4 1056 1 Human human JJ cord-009571-mygj2nd4 1056 2 MNL MNL NNP cord-009571-mygj2nd4 1056 3 obtained obtain VBN cord-009571-mygj2nd4 1056 4 by by IN cord-009571-mygj2nd4 1056 5 leukophoresis leukophoresis FW cord-009571-mygj2nd4 1056 6 ( ( -LRB- cord-009571-mygj2nd4 1056 7 IBM IBM NNP cord-009571-mygj2nd4 1056 8 cell cell NN cord-009571-mygj2nd4 1056 9 separator separator NN cord-009571-mygj2nd4 1056 10 ) ) -RRB- cord-009571-mygj2nd4 1056 11 of of IN cord-009571-mygj2nd4 1056 12 two two CD cord-009571-mygj2nd4 1056 13 nonrelated nonrelated JJ cord-009571-mygj2nd4 1056 14 healthy healthy JJ cord-009571-mygj2nd4 1056 15 individuals individual NNS cord-009571-mygj2nd4 1056 16 ( ( -LRB- cord-009571-mygj2nd4 1056 17 yield yield VB cord-009571-mygj2nd4 1056 18 = = SYM cord-009571-mygj2nd4 1056 19 1 1 CD cord-009571-mygj2nd4 1056 20 - - SYM cord-009571-mygj2nd4 1056 21 2 2 CD cord-009571-mygj2nd4 1056 22 X x NN cord-009571-mygj2nd4 1056 23 loLo lolo NN cord-009571-mygj2nd4 1056 24 cells cell NNS cord-009571-mygj2nd4 1056 25 / / SYM cord-009571-mygj2nd4 1056 26 donor donor NN cord-009571-mygj2nd4 1056 27 ) ) -RRB- cord-009571-mygj2nd4 1056 28 were be VBD cord-009571-mygj2nd4 1056 29 cultured culture VBN cord-009571-mygj2nd4 1056 30 together together RB cord-009571-mygj2nd4 1056 31 . . . cord-009571-mygj2nd4 1057 1 ( ( -LRB- cord-009571-mygj2nd4 1057 2 2.5 2.5 CD cord-009571-mygj2nd4 1057 3 X x NN cord-009571-mygj2nd4 1057 4 1V 1V NNP cord-009571-mygj2nd4 1057 5 cells cell NNS cord-009571-mygj2nd4 1057 6 / / SYM cord-009571-mygj2nd4 1057 7 ml ml NNS cord-009571-mygj2nd4 1057 8 , , , cord-009571-mygj2nd4 1057 9 40 40 CD cord-009571-mygj2nd4 1057 10 hours hour NNS cord-009571-mygj2nd4 1057 11 , , . cord-009571-mygj2nd4 1058 1 37"C 37"c LS cord-009571-mygj2nd4 1058 2 , , , cord-009571-mygj2nd4 1058 3 Mishell Mishell NNP cord-009571-mygj2nd4 1058 4 - - HYPH cord-009571-mygj2nd4 1058 5 Dutton Dutton NNP cord-009571-mygj2nd4 1058 6 atmosphere atmosphere NN cord-009571-mygj2nd4 1058 7 ) ) -RRB- cord-009571-mygj2nd4 1058 8 . . . cord-009571-mygj2nd4 1059 1 Supernatant supernatant JJ cord-009571-mygj2nd4 1059 2 fluids fluid NNS cord-009571-mygj2nd4 1059 3 were be VBD cord-009571-mygj2nd4 1059 4 removed remove VBN cord-009571-mygj2nd4 1059 5 and and CC cord-009571-mygj2nd4 1059 6 assayed assay VBN cord-009571-mygj2nd4 1059 7 for for IN cord-009571-mygj2nd4 1059 8 bone bone NN cord-009571-mygj2nd4 1059 9 resorbing resorbing NN cord-009571-mygj2nd4 1059 10 activity activity NN cord-009571-mygj2nd4 1059 11 by by IN cord-009571-mygj2nd4 1059 12 measurement measurement NN cord-009571-mygj2nd4 1059 13 of of IN cord-009571-mygj2nd4 1059 14 Ca46 Ca46 NNP cord-009571-mygj2nd4 1060 1 release release NN cord-009571-mygj2nd4 1060 2 from from IN cord-009571-mygj2nd4 1060 3 fetal fetal JJ cord-009571-mygj2nd4 1060 4 rat rat NN cord-009571-mygj2nd4 1060 5 bones bone NNS cord-009571-mygj2nd4 1060 6 in in IN cord-009571-mygj2nd4 1060 7 vitro vitro FW cord-009571-mygj2nd4 1060 8 . . . cord-009571-mygj2nd4 1061 1 These these DT cord-009571-mygj2nd4 1061 2 supernatants supernatant NNS cord-009571-mygj2nd4 1061 3 effected effect VBD cord-009571-mygj2nd4 1061 4 significant significant JJ cord-009571-mygj2nd4 1061 5 bone bone NN cord-009571-mygj2nd4 1061 6 resorption resorption NN cord-009571-mygj2nd4 1061 7 when when WRB cord-009571-mygj2nd4 1061 8 compared compare VBN cord-009571-mygj2nd4 1061 9 to to IN cord-009571-mygj2nd4 1061 10 either either CC cord-009571-mygj2nd4 1061 11 control control NN cord-009571-mygj2nd4 1061 12 supernatants supernatant NNS cord-009571-mygj2nd4 1061 13 prepared prepare VBN cord-009571-mygj2nd4 1061 14 from from IN cord-009571-mygj2nd4 1061 15 a a DT cord-009571-mygj2nd4 1061 16 single single JJ cord-009571-mygj2nd4 1061 17 donor donor NN cord-009571-mygj2nd4 1061 18 's 's POS cord-009571-mygj2nd4 1061 19 cells cell NNS cord-009571-mygj2nd4 1061 20 or or CC cord-009571-mygj2nd4 1061 21 medium medium NN cord-009571-mygj2nd4 1061 22 alone alone RB cord-009571-mygj2nd4 1061 23 . . . cord-009571-mygj2nd4 1062 1 Indomethacin Indomethacin NNP cord-009571-mygj2nd4 1062 2 ( ( -LRB- cord-009571-mygj2nd4 1062 3 5 5 CD cord-009571-mygj2nd4 1062 4 X x NN cord-009571-mygj2nd4 1062 5 to to IN cord-009571-mygj2nd4 1062 6 1 1 CD cord-009571-mygj2nd4 1062 7 x x SYM cord-009571-mygj2nd4 1062 8 1WM 1wm CD cord-009571-mygj2nd4 1062 9 ) ) -RRB- cord-009571-mygj2nd4 1062 10 did do VBD cord-009571-mygj2nd4 1062 11 not not RB cord-009571-mygj2nd4 1062 12 inhibit inhibit VB cord-009571-mygj2nd4 1062 13 either either CC cord-009571-mygj2nd4 1062 14 the the DT cord-009571-mygj2nd4 1062 15 production production NN cord-009571-mygj2nd4 1062 16 or or CC cord-009571-mygj2nd4 1062 17 biological biological JJ cord-009571-mygj2nd4 1062 18 activity activity NN cord-009571-mygj2nd4 1062 19 of of IN cord-009571-mygj2nd4 1062 20 this this DT cord-009571-mygj2nd4 1062 21 factor(s factor(s NNP cord-009571-mygj2nd4 1062 22 ) ) -RRB- cord-009571-mygj2nd4 1062 23 . . . cord-009571-mygj2nd4 1063 1 Bone bone NN cord-009571-mygj2nd4 1063 2 resorbing resorbing NN cord-009571-mygj2nd4 1063 3 activity activity NN cord-009571-mygj2nd4 1063 4 eluted elute VBN cord-009571-mygj2nd4 1063 5 with with IN cord-009571-mygj2nd4 1063 6 molecules molecule NNS cord-009571-mygj2nd4 1063 7 of of IN cord-009571-mygj2nd4 1063 8 11 11 CD cord-009571-mygj2nd4 1063 9 - - HYPH cord-009571-mygj2nd4 1063 10 18,oOO 18,ooo CD cord-009571-mygj2nd4 1063 11 daltons dalton NNS cord-009571-mygj2nd4 1063 12 on on IN cord-009571-mygj2nd4 1063 13 Sephadex Sephadex NNP cord-009571-mygj2nd4 1063 14 G-75 G-75 NNP cord-009571-mygj2nd4 1063 15 and and CC cord-009571-mygj2nd4 1063 16 appeared appear VBD cord-009571-mygj2nd4 1063 17 in in IN cord-009571-mygj2nd4 1063 18 the the DT cord-009571-mygj2nd4 1063 19 breakthrough breakthrough NN cord-009571-mygj2nd4 1063 20 when when WRB cord-009571-mygj2nd4 1063 21 applied apply VBN cord-009571-mygj2nd4 1063 22 to to IN cord-009571-mygj2nd4 1063 23 DEAE DEAE NNP cord-009571-mygj2nd4 1063 24 cellulose cellulose NN cord-009571-mygj2nd4 1063 25 ( ( -LRB- cord-009571-mygj2nd4 1063 26 0.005 0.005 CD cord-009571-mygj2nd4 1063 27 M m NN cord-009571-mygj2nd4 1063 28 phosphate phosphate NN cord-009571-mygj2nd4 1063 29 , , , cord-009571-mygj2nd4 1063 30 0.02 0.02 CD cord-009571-mygj2nd4 1063 31 M M NNP cord-009571-mygj2nd4 1063 32 NaCI NaCI NNP cord-009571-mygj2nd4 1063 33 , , , cord-009571-mygj2nd4 1063 34 pH pH NNP cord-009571-mygj2nd4 1063 35 7.5 7.5 CD cord-009571-mygj2nd4 1063 36 ) ) -RRB- cord-009571-mygj2nd4 1063 37 . . . cord-009571-mygj2nd4 1064 1 Eluate eluate NN cord-009571-mygj2nd4 1064 2 containing contain VBG cord-009571-mygj2nd4 1064 3 bone bone NN cord-009571-mygj2nd4 1064 4 resorbing resorbing NN cord-009571-mygj2nd4 1064 5 activity activity NN cord-009571-mygj2nd4 1064 6 after after IN cord-009571-mygj2nd4 1064 7 Sephadex Sephadex NNP cord-009571-mygj2nd4 1064 8 G-75 G-75 NNP cord-009571-mygj2nd4 1064 9 chromatography chromatography NN cord-009571-mygj2nd4 1064 10 X x NN cord-009571-mygj2nd4 1064 11 2 2 CD cord-009571-mygj2nd4 1064 12 and and CC cord-009571-mygj2nd4 1064 13 DEAE DEAE NNP cord-009571-mygj2nd4 1064 14 cellulose cellulose NN cord-009571-mygj2nd4 1064 15 Chromatography Chromatography NNP cord-009571-mygj2nd4 1064 16 was be VBD cord-009571-mygj2nd4 1064 17 applied apply VBN cord-009571-mygj2nd4 1064 18 to to IN cord-009571-mygj2nd4 1064 19 amionic amionic NNP cord-009571-mygj2nd4 1064 20 disc disc NN cord-009571-mygj2nd4 1064 21 gels gel NNS cord-009571-mygj2nd4 1064 22 ( ( -LRB- cord-009571-mygj2nd4 1064 23 4"C 4"c CD cord-009571-mygj2nd4 1064 24 , , , cord-009571-mygj2nd4 1064 25 pH pH NNP cord-009571-mygj2nd4 1064 26 9.3 9.3 CD cord-009571-mygj2nd4 1064 27 , , , cord-009571-mygj2nd4 1064 28 Trisglycine Trisglycine NNP cord-009571-mygj2nd4 1064 29 ) ) -RRB- cord-009571-mygj2nd4 1064 30 . . . cord-009571-mygj2nd4 1065 1 A a DT cord-009571-mygj2nd4 1065 2 single single JJ cord-009571-mygj2nd4 1065 3 peak peak NN cord-009571-mygj2nd4 1065 4 of of IN cord-009571-mygj2nd4 1065 5 bone bone NN cord-009571-mygj2nd4 1065 6 resorbing resorbing NN cord-009571-mygj2nd4 1065 7 activity activity NN cord-009571-mygj2nd4 1065 8 was be VBD cord-009571-mygj2nd4 1065 9 observed observe VBN cord-009571-mygj2nd4 1065 10 , , , cord-009571-mygj2nd4 1065 11 although although IN cord-009571-mygj2nd4 1065 12 this this DT cord-009571-mygj2nd4 1065 13 activity activity NN cord-009571-mygj2nd4 1065 14 could could MD cord-009571-mygj2nd4 1065 15 not not RB cord-009571-mygj2nd4 1065 16 be be VB cord-009571-mygj2nd4 1065 17 attributed attribute VBN cord-009571-mygj2nd4 1065 18 to to IN cord-009571-mygj2nd4 1065 19 a a DT cord-009571-mygj2nd4 1065 20 stainable stainable JJ cord-009571-mygj2nd4 1065 21 protein protein NN cord-009571-mygj2nd4 1065 22 bond bond NN cord-009571-mygj2nd4 1065 23 . . . cord-009571-mygj2nd4 1066 1 The the DT cord-009571-mygj2nd4 1066 2 results result NNS cord-009571-mygj2nd4 1066 3 indicate indicate VBP cord-009571-mygj2nd4 1066 4 that that IN cord-009571-mygj2nd4 1066 5 alloantigen alloantigen NN cord-009571-mygj2nd4 1066 6 stimulated stimulate VBN cord-009571-mygj2nd4 1066 7 human human JJ cord-009571-mygj2nd4 1066 8 MNL MNL NNP cord-009571-mygj2nd4 1066 9 elaborate elaborate VBP cord-009571-mygj2nd4 1066 10 a a DT cord-009571-mygj2nd4 1066 11 low low JJ cord-009571-mygj2nd4 1066 12 molecular molecular JJ cord-009571-mygj2nd4 1066 13 weight weight NN cord-009571-mygj2nd4 1066 14 bone bone NN cord-009571-mygj2nd4 1066 15 resorbing resorb VBG cord-009571-mygj2nd4 1066 16 factor(s factor(s NNP cord-009571-mygj2nd4 1066 17 ) ) -RRB- cord-009571-mygj2nd4 1066 18 resembling resemble VBG cord-009571-mygj2nd4 1066 19 the the DT cord-009571-mygj2nd4 1066 20 previously previously RB cord-009571-mygj2nd4 1066 21 described describe VBN cord-009571-mygj2nd4 1066 22 osteoclast osteoclast NN cord-009571-mygj2nd4 1066 23 activating activate VBG cord-009571-mygj2nd4 1066 24 factor factor NN cord-009571-mygj2nd4 1066 25 ( ( -LRB- cord-009571-mygj2nd4 1066 26 OAF OAF NNP cord-009571-mygj2nd4 1066 27 ) ) -RRB- cord-009571-mygj2nd4 1066 28 . . . cord-009571-mygj2nd4 1067 1 Methods method NNS cord-009571-mygj2nd4 1067 2 presented present VBN cord-009571-mygj2nd4 1067 3 for for IN cord-009571-mygj2nd4 1067 4 the the DT cord-009571-mygj2nd4 1067 5 large large JJ cord-009571-mygj2nd4 1067 6 - - HYPH cord-009571-mygj2nd4 1067 7 scale scale NN cord-009571-mygj2nd4 1067 8 generation generation NN cord-009571-mygj2nd4 1067 9 and and CC cord-009571-mygj2nd4 1067 10 partial partial JJ cord-009571-mygj2nd4 1067 11 purification purification NN cord-009571-mygj2nd4 1067 12 of of IN cord-009571-mygj2nd4 1067 13 this this DT cord-009571-mygj2nd4 1067 14 activity activity NN cord-009571-mygj2nd4 1067 15 should should MD cord-009571-mygj2nd4 1067 16 facilitate facilitate VB cord-009571-mygj2nd4 1067 17 clarification clarification NN cord-009571-mygj2nd4 1067 18 of of IN cord-009571-mygj2nd4 1067 19 the the DT cord-009571-mygj2nd4 1067 20 role role NN cord-009571-mygj2nd4 1067 21 of of IN cord-009571-mygj2nd4 1067 22 this this DT cord-009571-mygj2nd4 1067 23 factor factor NN cord-009571-mygj2nd4 1067 24 in in IN cord-009571-mygj2nd4 1067 25 immune immune JJ cord-009571-mygj2nd4 1067 26 tissue tissue NN cord-009571-mygj2nd4 1067 27 destruction destruction NN cord-009571-mygj2nd4 1067 28 . . . cord-009571-mygj2nd4 1068 1 Inflammatory inflammatory JJ cord-009571-mygj2nd4 1068 2 cells cell NNS cord-009571-mygj2nd4 1068 3 may may MD cord-009571-mygj2nd4 1068 4 play play VB cord-009571-mygj2nd4 1068 5 a a DT cord-009571-mygj2nd4 1068 6 role role NN cord-009571-mygj2nd4 1068 7 in in IN cord-009571-mygj2nd4 1068 8 modulating modulate VBG cord-009571-mygj2nd4 1068 9 connective connective JJ cord-009571-mygj2nd4 1068 10 tissue tissue NN cord-009571-mygj2nd4 1068 11 growth growth NN cord-009571-mygj2nd4 1068 12 and and CC cord-009571-mygj2nd4 1068 13 function function VB cord-009571-mygj2nd4 1068 14 in in IN cord-009571-mygj2nd4 1068 15 a a DT cord-009571-mygj2nd4 1068 16 number number NN cord-009571-mygj2nd4 1068 17 of of IN cord-009571-mygj2nd4 1068 18 rheumatic rheumatic JJ cord-009571-mygj2nd4 1068 19 diseases disease NNS cord-009571-mygj2nd4 1068 20 . . . cord-009571-mygj2nd4 1069 1 The the DT cord-009571-mygj2nd4 1069 2 interaction interaction NN cord-009571-mygj2nd4 1069 3 of of IN cord-009571-mygj2nd4 1069 4 lymphoid lymphoid JJ cord-009571-mygj2nd4 1069 5 and and CC cord-009571-mygj2nd4 1069 6 connective connective JJ cord-009571-mygj2nd4 1069 7 tissue tissue NN cord-009571-mygj2nd4 1069 8 cells cell NNS cord-009571-mygj2nd4 1069 9 was be VBD cord-009571-mygj2nd4 1069 10 studied study VBN cord-009571-mygj2nd4 1069 11 in in IN cord-009571-mygj2nd4 1069 12 vitro vitro FW cord-009571-mygj2nd4 1069 13 by by IN cord-009571-mygj2nd4 1069 14 exposing expose VBG cord-009571-mygj2nd4 1069 15 human human JJ cord-009571-mygj2nd4 1069 16 dermal dermal JJ cord-009571-mygj2nd4 1069 17 fibroblasts fibroblast NNS cord-009571-mygj2nd4 1069 18 ( ( -LRB- cord-009571-mygj2nd4 1069 19 FB FB NNP cord-009571-mygj2nd4 1069 20 ) ) -RRB- cord-009571-mygj2nd4 1069 21 to to IN cord-009571-mygj2nd4 1069 22 supernatants supernatant NNS cord-009571-mygj2nd4 1069 23 ( ( -LRB- cord-009571-mygj2nd4 1069 24 SN SN NNP cord-009571-mygj2nd4 1069 25 ) ) -RRB- cord-009571-mygj2nd4 1069 26 of of IN cord-009571-mygj2nd4 1069 27 peripheral peripheral JJ cord-009571-mygj2nd4 1069 28 blood blood NN cord-009571-mygj2nd4 1069 29 mononuclear mononuclear NN cord-009571-mygj2nd4 1069 30 cells cell NNS cord-009571-mygj2nd4 1069 31 ( ( -LRB- cord-009571-mygj2nd4 1069 32 PBMC PBMC NNP cord-009571-mygj2nd4 1069 33 ) ) -RRB- cord-009571-mygj2nd4 1069 34 . . . cord-009571-mygj2nd4 1070 1 Proliferation proliferation NN cord-009571-mygj2nd4 1070 2 was be VBD cord-009571-mygj2nd4 1070 3 assessed assess VBN cord-009571-mygj2nd4 1070 4 by by IN cord-009571-mygj2nd4 1070 5 BH bh NN cord-009571-mygj2nd4 1070 6 - - HYPH cord-009571-mygj2nd4 1070 7 thymidine thymidine NN cord-009571-mygj2nd4 1070 8 incorporation incorporation NN cord-009571-mygj2nd4 1070 9 and and CC cord-009571-mygj2nd4 1070 10 direct direct JJ cord-009571-mygj2nd4 1070 11 cdl cdl NN cord-009571-mygj2nd4 1070 12 counts count NNS cord-009571-mygj2nd4 1070 13 . . . cord-009571-mygj2nd4 1071 1 Protein protein NN cord-009571-mygj2nd4 1071 2 synthesis synthesis NN cord-009571-mygj2nd4 1071 3 was be VBD cord-009571-mygj2nd4 1071 4 determined determine VBN cord-009571-mygj2nd4 1071 5 by by IN cord-009571-mygj2nd4 1071 6 aH aH NNP cord-009571-mygj2nd4 1071 7 - - HYPH cord-009571-mygj2nd4 1071 8 proline proline NN cord-009571-mygj2nd4 1071 9 incorporation incorporation NN cord-009571-mygj2nd4 1071 10 and and CC cord-009571-mygj2nd4 1071 11 collagen collagen NN cord-009571-mygj2nd4 1071 12 synthesis synthesis NN cord-009571-mygj2nd4 1071 13 by by IN cord-009571-mygj2nd4 1071 14 protease protease NN cord-009571-mygj2nd4 1071 15 - - HYPH cord-009571-mygj2nd4 1071 16 free free JJ cord-009571-mygj2nd4 1071 17 collagenase collagenase NN cord-009571-mygj2nd4 1071 18 releasable releasable JJ cord-009571-mygj2nd4 1071 19 counts count NNS cord-009571-mygj2nd4 1071 20 . . . cord-009571-mygj2nd4 1072 1 SN SN NNP cord-009571-mygj2nd4 1072 2 of of IN cord-009571-mygj2nd4 1072 3 both both CC cord-009571-mygj2nd4 1072 4 unstimulated unstimulated JJ cord-009571-mygj2nd4 1072 5 and and CC cord-009571-mygj2nd4 1072 6 PHA PHA NNP cord-009571-mygj2nd4 1072 7 - - HYPH cord-009571-mygj2nd4 1072 8 stimulated stimulate VBN cord-009571-mygj2nd4 1072 9 PBMC PBMC NNP cord-009571-mygj2nd4 1072 10 suppressed suppress VBD cord-009571-mygj2nd4 1072 11 FB fb NN cord-009571-mygj2nd4 1072 12 growth growth NN cord-009571-mygj2nd4 1072 13 in in IN cord-009571-mygj2nd4 1072 14 a a DT cord-009571-mygj2nd4 1072 15 dose dose NN cord-009571-mygj2nd4 1072 16 - - HYPH cord-009571-mygj2nd4 1072 17 dependent dependent JJ cord-009571-mygj2nd4 1072 18 fashion fashion NN cord-009571-mygj2nd4 1072 19 . . . cord-009571-mygj2nd4 1073 1 SN SN NNP cord-009571-mygj2nd4 1073 2 suppressive suppressive JJ cord-009571-mygj2nd4 1073 3 activity activity NN cord-009571-mygj2nd4 1073 4 was be VBD cord-009571-mygj2nd4 1073 5 non non JJ cord-009571-mygj2nd4 1073 6 - - JJ cord-009571-mygj2nd4 1073 7 dialyzable dialyzable JJ cord-009571-mygj2nd4 1073 8 , , , cord-009571-mygj2nd4 1073 9 heat heat NN cord-009571-mygj2nd4 1073 10 - - HYPH cord-009571-mygj2nd4 1073 11 stable stable JJ cord-009571-mygj2nd4 1073 12 , , , cord-009571-mygj2nd4 1073 13 not not RB cord-009571-mygj2nd4 1073 14 cytotoxic cytotoxic JJ cord-009571-mygj2nd4 1073 15 , , , cord-009571-mygj2nd4 1073 16 and and CC cord-009571-mygj2nd4 1073 17 removed remove VBN cord-009571-mygj2nd4 1073 18 by by IN cord-009571-mygj2nd4 1073 19 absorption absorption NN cord-009571-mygj2nd4 1073 20 of of IN cord-009571-mygj2nd4 1073 21 SN SN NNP cord-009571-mygj2nd4 1073 22 with with IN cord-009571-mygj2nd4 1073 23 FB fb NN cord-009571-mygj2nd4 1073 24 but but CC cord-009571-mygj2nd4 1073 25 not not RB cord-009571-mygj2nd4 1073 26 with with IN cord-009571-mygj2nd4 1073 27 PBMC PBMC NNP cord-009571-mygj2nd4 1073 28 . . . cord-009571-mygj2nd4 1074 1 There there EX cord-009571-mygj2nd4 1074 2 was be VBD cord-009571-mygj2nd4 1074 3 suppression suppression NN cord-009571-mygj2nd4 1074 4 of of IN cord-009571-mygj2nd4 1074 5 protein protein NN cord-009571-mygj2nd4 1074 6 synthesis synthesis NN cord-009571-mygj2nd4 1074 7 by by IN cord-009571-mygj2nd4 1074 8 PBMC PBMC NNP cord-009571-mygj2nd4 1074 9 - - HYPH cord-009571-mygj2nd4 1074 10 SN SN NNP cord-009571-mygj2nd4 1074 11 in in IN cord-009571-mygj2nd4 1074 12 direct direct JJ cord-009571-mygj2nd4 1074 13 proportion proportion NN cord-009571-mygj2nd4 1074 14 to to IN cord-009571-mygj2nd4 1074 15 the the DT cord-009571-mygj2nd4 1074 16 suppression suppression NN cord-009571-mygj2nd4 1074 17 of of IN cord-009571-mygj2nd4 1074 18 cell cell NN cord-009571-mygj2nd4 1074 19 number number NN cord-009571-mygj2nd4 1074 20 ( ( -LRB- cord-009571-mygj2nd4 1074 21 41 41 CD cord-009571-mygj2nd4 1074 22 % % NN cord-009571-mygj2nd4 1074 23 ) ) -RRB- cord-009571-mygj2nd4 1074 24 , , , cord-009571-mygj2nd4 1074 25 but but CC cord-009571-mygj2nd4 1074 26 disproportionately disproportionately RB cord-009571-mygj2nd4 1074 27 greater great JJR cord-009571-mygj2nd4 1074 28 suppression suppression NN cord-009571-mygj2nd4 1074 29 of of IN cord-009571-mygj2nd4 1074 30 collagen collagen NN cord-009571-mygj2nd4 1074 31 synthesis synthesis NN cord-009571-mygj2nd4 1074 32 ( ( -LRB- cord-009571-mygj2nd4 1074 33 68 68 CD cord-009571-mygj2nd4 1074 34 % % NN cord-009571-mygj2nd4 1074 35 ) ) -RRB- cord-009571-mygj2nd4 1074 36 . . . cord-009571-mygj2nd4 1075 1 Culture culture NN cord-009571-mygj2nd4 1075 2 SN SN NNP cord-009571-mygj2nd4 1075 3 of of IN cord-009571-mygj2nd4 1075 4 T t NN cord-009571-mygj2nd4 1075 5 - - HYPH cord-009571-mygj2nd4 1075 6 cell cell NN cord-009571-mygj2nd4 1075 7 depleted deplete VBN cord-009571-mygj2nd4 1075 8 PBMC PBMC NNS cord-009571-mygj2nd4 1075 9 were be VBD cord-009571-mygj2nd4 1075 10 as as RB cord-009571-mygj2nd4 1075 11 active active JJ cord-009571-mygj2nd4 1075 12 in in IN cord-009571-mygj2nd4 1075 13 suppressing suppress VBG cord-009571-mygj2nd4 1075 14 FB fb NN cord-009571-mygj2nd4 1075 15 growth growth NN cord-009571-mygj2nd4 1075 16 as as IN cord-009571-mygj2nd4 1075 17 were be VBD cord-009571-mygj2nd4 1075 18 SN SN NNP cord-009571-mygj2nd4 1075 19 of of IN cord-009571-mygj2nd4 1075 20 unfractionated unfractionated JJ cord-009571-mygj2nd4 1075 21 MC MC NNP cord-009571-mygj2nd4 1075 22 ( ( -LRB- cord-009571-mygj2nd4 1075 23 46 46 CD cord-009571-mygj2nd4 1075 24 - - SYM cord-009571-mygj2nd4 1075 25 63 63 CD cord-009571-mygj2nd4 1075 26 % % NN cord-009571-mygj2nd4 1075 27 suppression suppression NN cord-009571-mygj2nd4 1075 28 , , , cord-009571-mygj2nd4 1075 29 mean mean VBP cord-009571-mygj2nd4 1075 30 54 54 CD cord-009571-mygj2nd4 1075 31 f f NN cord-009571-mygj2nd4 1075 32 7 7 CD cord-009571-mygj2nd4 1075 33 % % NN cord-009571-mygj2nd4 1075 34 for for IN cord-009571-mygj2nd4 1075 35 T t NN cord-009571-mygj2nd4 1075 36 - - HYPH cord-009571-mygj2nd4 1075 37 depleted deplete VBN cord-009571-mygj2nd4 1075 38 versus versus IN cord-009571-mygj2nd4 1075 39 41 41 CD cord-009571-mygj2nd4 1075 40 - - SYM cord-009571-mygj2nd4 1075 41 59 59 CD cord-009571-mygj2nd4 1075 42 % % NN cord-009571-mygj2nd4 1075 43 , , , cord-009571-mygj2nd4 1075 44 mean mean JJ cord-009571-mygj2nd4 1076 1 48 48 CD cord-009571-mygj2nd4 1076 2 f f NN cord-009571-mygj2nd4 1076 3 8 8 CD cord-009571-mygj2nd4 1076 4 % % NN cord-009571-mygj2nd4 1076 5 for for IN cord-009571-mygj2nd4 1076 6 unfractionated unfractionated JJ cord-009571-mygj2nd4 1076 7 ) ) -RRB- cord-009571-mygj2nd4 1076 8 . . . cord-009571-mygj2nd4 1077 1 Supernatants supernatant NNS cord-009571-mygj2nd4 1077 2 of of IN cord-009571-mygj2nd4 1077 3 T t NN cord-009571-mygj2nd4 1077 4 - - HYPH cord-009571-mygj2nd4 1077 5 cell cell NN cord-009571-mygj2nd4 1077 6 enriched enrich VBN cord-009571-mygj2nd4 1077 7 populations population NNS cord-009571-mygj2nd4 1077 8 had have VBD cord-009571-mygj2nd4 1077 9 decreased decrease VBN cord-009571-mygj2nd4 1077 10 activity activity NN cord-009571-mygj2nd4 1077 11 ( ( -LRB- cord-009571-mygj2nd4 1077 12 8 8 CD cord-009571-mygj2nd4 1077 13 - - SYM cord-009571-mygj2nd4 1077 14 20 20 CD cord-009571-mygj2nd4 1077 15 % % NN cord-009571-mygj2nd4 1077 16 , , , cord-009571-mygj2nd4 1077 17 mean mean VBP cord-009571-mygj2nd4 1077 18 16 16 CD cord-009571-mygj2nd4 1077 19 f f NN cord-009571-mygj2nd4 1077 20 6 6 CD cord-009571-mygj2nd4 1077 21 % % NN cord-009571-mygj2nd4 1077 22 suppression suppression NN cord-009571-mygj2nd4 1077 23 ) ) -RRB- cord-009571-mygj2nd4 1077 24 . . . cord-009571-mygj2nd4 1078 1 The the DT cord-009571-mygj2nd4 1078 2 growth growth NN cord-009571-mygj2nd4 1078 3 suppression suppression NN cord-009571-mygj2nd4 1078 4 seen see VBN cord-009571-mygj2nd4 1078 5 was be VBD cord-009571-mygj2nd4 1078 6 due due JJ cord-009571-mygj2nd4 1078 7 , , , cord-009571-mygj2nd4 1078 8 at at IN cord-009571-mygj2nd4 1078 9 least least JJS cord-009571-mygj2nd4 1078 10 in in IN cord-009571-mygj2nd4 1078 11 part part NN cord-009571-mygj2nd4 1078 12 , , , cord-009571-mygj2nd4 1078 13 to to IN cord-009571-mygj2nd4 1078 14 stimulation stimulation NN cord-009571-mygj2nd4 1078 15 of of IN cord-009571-mygj2nd4 1078 16 FB fb NN cord-009571-mygj2nd4 1078 17 prostaglandin prostaglandin NN cord-009571-mygj2nd4 1078 18 ( ( -LRB- cord-009571-mygj2nd4 1078 19 PG PG NNP cord-009571-mygj2nd4 1078 20 ) ) -RRB- cord-009571-mygj2nd4 1078 21 synthesis synthesis NN cord-009571-mygj2nd4 1078 22 . . . cord-009571-mygj2nd4 1079 1 Immunoreactive Immunoreactive NNP cord-009571-mygj2nd4 1079 2 PGE PGE NNP cord-009571-mygj2nd4 1079 3 , , , cord-009571-mygj2nd4 1079 4 production production NN cord-009571-mygj2nd4 1079 5 by by IN cord-009571-mygj2nd4 1079 6 FB FB NNP cord-009571-mygj2nd4 1079 7 was be VBD cord-009571-mygj2nd4 1079 8 increased increase VBN cord-009571-mygj2nd4 1079 9 70-fold 70-fold CD cord-009571-mygj2nd4 1079 10 ( ( -LRB- cord-009571-mygj2nd4 1079 11 1.3 1.3 CD cord-009571-mygj2nd4 1079 12 versus versus IN cord-009571-mygj2nd4 1079 13 90.0 90.0 CD cord-009571-mygj2nd4 1079 14 ng/106 ng/106 NN cord-009571-mygj2nd4 1079 15 cells cell NNS cord-009571-mygj2nd4 1079 16 ) ) -RRB- cord-009571-mygj2nd4 1079 17 by by IN cord-009571-mygj2nd4 1079 18 PBMC PBMC NNP cord-009571-mygj2nd4 1079 19 - - HYPH cord-009571-mygj2nd4 1079 20 SN SN NNP cord-009571-mygj2nd4 1079 21 . . . cord-009571-mygj2nd4 1080 1 When when WRB cord-009571-mygj2nd4 1080 2 inhibitors inhibitor NNS cord-009571-mygj2nd4 1080 3 of of IN cord-009571-mygj2nd4 1080 4 PG PG NNP cord-009571-mygj2nd4 1080 5 synthesis synthesis NN cord-009571-mygj2nd4 1080 6 ( ( -LRB- cord-009571-mygj2nd4 1080 7 indomethacin indomethacin NN cord-009571-mygj2nd4 1080 8 , , , cord-009571-mygj2nd4 1080 9 sodium sodium NN cord-009571-mygj2nd4 1080 10 meclofenamate meclofenamate NNP cord-009571-mygj2nd4 1080 11 ) ) -RRB- cord-009571-mygj2nd4 1080 12 were be VBD cord-009571-mygj2nd4 1080 13 added add VBN cord-009571-mygj2nd4 1080 14 to to IN cord-009571-mygj2nd4 1080 15 FB FB NNP cord-009571-mygj2nd4 1080 16 cultures culture NNS cord-009571-mygj2nd4 1080 17 just just RB cord-009571-mygj2nd4 1080 18 prior prior RB cord-009571-mygj2nd4 1080 19 to to IN cord-009571-mygj2nd4 1080 20 addition addition NN cord-009571-mygj2nd4 1080 21 of of IN cord-009571-mygj2nd4 1080 22 PBMC PBMC NNP cord-009571-mygj2nd4 1080 23 - - HYPH cord-009571-mygj2nd4 1080 24 SN SN NNP cord-009571-mygj2nd4 1080 25 , , , cord-009571-mygj2nd4 1080 26 the the DT cord-009571-mygj2nd4 1080 27 growth growth NN cord-009571-mygj2nd4 1080 28 suppressive suppressive JJ cord-009571-mygj2nd4 1080 29 effect effect NN cord-009571-mygj2nd4 1080 30 was be VBD cord-009571-mygj2nd4 1080 31 abrogated abrogate VBN cord-009571-mygj2nd4 1080 32 ( ( -LRB- cord-009571-mygj2nd4 1080 33 30 30 CD cord-009571-mygj2nd4 1080 34 - - SYM cord-009571-mygj2nd4 1080 35 100 100 CD cord-009571-mygj2nd4 1080 36 % % NN cord-009571-mygj2nd4 1080 37 ) ) -RRB- cord-009571-mygj2nd4 1080 38 . . . cord-009571-mygj2nd4 1081 1 Furthermore furthermore RB cord-009571-mygj2nd4 1081 2 , , , cord-009571-mygj2nd4 1081 3 exogenously exogenously RB cord-009571-mygj2nd4 1081 4 added add VBN cord-009571-mygj2nd4 1081 5 PGE PGE NNP cord-009571-mygj2nd4 1081 6 , , , cord-009571-mygj2nd4 1081 7 ( ( -LRB- cord-009571-mygj2nd4 1081 8 final final JJ cord-009571-mygj2nd4 1081 9 concentration concentration NN cord-009571-mygj2nd4 1081 10 = = SYM cord-009571-mygj2nd4 1081 11 50 50 CD cord-009571-mygj2nd4 1081 12 ng ng NN cord-009571-mygj2nd4 1081 13 / / SYM cord-009571-mygj2nd4 1081 14 ml ml NN cord-009571-mygj2nd4 1081 15 ) ) -RRB- cord-009571-mygj2nd4 1081 16 resulted result VBD cord-009571-mygj2nd4 1081 17 in in IN cord-009571-mygj2nd4 1081 18 suppression suppression NN cord-009571-mygj2nd4 1081 19 of of IN cord-009571-mygj2nd4 1081 20 FB FB NNP cord-009571-mygj2nd4 1081 21 growth growth NN cord-009571-mygj2nd4 1081 22 comparable comparable JJ cord-009571-mygj2nd4 1081 23 to to IN cord-009571-mygj2nd4 1081 24 that that DT cord-009571-mygj2nd4 1081 25 seen see VBN cord-009571-mygj2nd4 1081 26 with with IN cord-009571-mygj2nd4 1081 27 PBMC PBMC NNP cord-009571-mygj2nd4 1081 28 - - HYPH cord-009571-mygj2nd4 1081 29 SN SN NNP cord-009571-mygj2nd4 1081 30 . . . cord-009571-mygj2nd4 1082 1 Thus thus RB cord-009571-mygj2nd4 1082 2 , , , cord-009571-mygj2nd4 1082 3 lymphoid lymphoid JJ cord-009571-mygj2nd4 1082 4 cells cell NNS cord-009571-mygj2nd4 1082 5 produce produce VBP cord-009571-mygj2nd4 1082 6 soluble soluble JJ cord-009571-mygj2nd4 1082 7 factors factor NNS cord-009571-mygj2nd4 1082 8 which which WDT cord-009571-mygj2nd4 1082 9 induce induce VBP cord-009571-mygj2nd4 1082 10 FB FB NNP cord-009571-mygj2nd4 1082 11 to to TO cord-009571-mygj2nd4 1082 12 modulate modulate VB cord-009571-mygj2nd4 1082 13 their -PRON- PRP$ cord-009571-mygj2nd4 1082 14 own own JJ cord-009571-mygj2nd4 1082 15 growth growth NN cord-009571-mygj2nd4 1082 16 in in IN cord-009571-mygj2nd4 1082 17 vitro vitro FW cord-009571-mygj2nd4 1082 18 and and CC cord-009571-mygj2nd4 1082 19 which which WDT cord-009571-mygj2nd4 1082 20 alter alter VBP cord-009571-mygj2nd4 1082 21 collagen collagen NN cord-009571-mygj2nd4 1082 22 synthesis synthesis NN cord-009571-mygj2nd4 1082 23 . . . cord-009571-mygj2nd4 1083 1 The the DT cord-009571-mygj2nd4 1083 2 effector effector NN cord-009571-mygj2nd4 1083 3 of of IN cord-009571-mygj2nd4 1083 4 the the DT cord-009571-mygj2nd4 1083 5 growth growth NN cord-009571-mygj2nd4 1083 6 autoregulation autoregulation NN cord-009571-mygj2nd4 1083 7 appears appear VBZ cord-009571-mygj2nd4 1083 8 to to TO cord-009571-mygj2nd4 1083 9 be be VB cord-009571-mygj2nd4 1083 10 a a DT cord-009571-mygj2nd4 1083 11 PG PG NNP cord-009571-mygj2nd4 1083 12 . . . cord-009571-mygj2nd4 1084 1 This this DT cord-009571-mygj2nd4 1084 2 system system NN cord-009571-mygj2nd4 1084 3 provides provide VBZ cord-009571-mygj2nd4 1084 4 an an DT cord-009571-mygj2nd4 1084 5 in in FW cord-009571-mygj2nd4 1084 6 vitro vitro FW cord-009571-mygj2nd4 1084 7 model model NN cord-009571-mygj2nd4 1084 8 for for IN cord-009571-mygj2nd4 1084 9 the the DT cord-009571-mygj2nd4 1084 10 study study NN cord-009571-mygj2nd4 1084 11 of of IN cord-009571-mygj2nd4 1084 12 lymphoid lymphoid JJ cord-009571-mygj2nd4 1084 13 and and CC cord-009571-mygj2nd4 1084 14 connective connective JJ cord-009571-mygj2nd4 1084 15 tissue tissue NN cord-009571-mygj2nd4 1084 16 cell cell NN cord-009571-mygj2nd4 1084 17 interaction interaction NN cord-009571-mygj2nd4 1084 18 which which WDT cord-009571-mygj2nd4 1084 19 may may MD cord-009571-mygj2nd4 1084 20 improve improve VB cord-009571-mygj2nd4 1084 21 the the DT cord-009571-mygj2nd4 1084 22 understanding understanding NN cord-009571-mygj2nd4 1084 23 of of IN cord-009571-mygj2nd4 1084 24 proliferative proliferative JJ cord-009571-mygj2nd4 1084 25 and and CC cord-009571-mygj2nd4 1084 26 fibrotic fibrotic JJ cord-009571-mygj2nd4 1084 27 human human JJ cord-009571-mygj2nd4 1084 28 disease disease NN cord-009571-mygj2nd4 1084 29 . . . cord-009571-mygj2nd4 1085 1 Although although IN cord-009571-mygj2nd4 1085 2 there there EX cord-009571-mygj2nd4 1085 3 is be VBZ cord-009571-mygj2nd4 1085 4 compelling compelling JJ cord-009571-mygj2nd4 1085 5 evidence evidence NN cord-009571-mygj2nd4 1085 6 to to TO cord-009571-mygj2nd4 1085 7 support support VB cord-009571-mygj2nd4 1085 8 the the DT cord-009571-mygj2nd4 1085 9 view view NN cord-009571-mygj2nd4 1085 10 that that WDT cord-009571-mygj2nd4 1085 11 altered alter VBD cord-009571-mygj2nd4 1085 12 endocytic endocytic JJ cord-009571-mygj2nd4 1085 13 - - HYPH cord-009571-mygj2nd4 1085 14 lysosomal lysosomal JJ cord-009571-mygj2nd4 1085 15 functions function NNS cord-009571-mygj2nd4 1085 16 of of IN cord-009571-mygj2nd4 1085 17 synovial synovial JJ cord-009571-mygj2nd4 1085 18 tissue tissue NN cord-009571-mygj2nd4 1085 19 may may MD cord-009571-mygj2nd4 1085 20 play play VB cord-009571-mygj2nd4 1085 21 a a DT cord-009571-mygj2nd4 1085 22 role role NN cord-009571-mygj2nd4 1085 23 in in IN cord-009571-mygj2nd4 1085 24 the the DT cord-009571-mygj2nd4 1085 25 joint joint JJ cord-009571-mygj2nd4 1085 26 tissue tissue NN cord-009571-mygj2nd4 1085 27 injury injury NN cord-009571-mygj2nd4 1085 28 seen see VBN cord-009571-mygj2nd4 1085 29 in in IN cord-009571-mygj2nd4 1085 30 rheuma rheuma NNP cord-009571-mygj2nd4 1085 31 - - HYPH cord-009571-mygj2nd4 1085 32 toid toid NNP cord-009571-mygj2nd4 1085 33 arthritis arthritis NN cord-009571-mygj2nd4 1085 34 ( ( -LRB- cord-009571-mygj2nd4 1085 35 RA RA NNP cord-009571-mygj2nd4 1085 36 ) ) -RRB- cord-009571-mygj2nd4 1085 37 , , , cord-009571-mygj2nd4 1085 38 there there EX cord-009571-mygj2nd4 1085 39 are be VBP cord-009571-mygj2nd4 1085 40 no no DT cord-009571-mygj2nd4 1085 41 data data NN cord-009571-mygj2nd4 1085 42 which which WDT cord-009571-mygj2nd4 1085 43 quantitate quantitate VBP cord-009571-mygj2nd4 1085 44 these these DT cord-009571-mygj2nd4 1085 45 functions function NNS cord-009571-mygj2nd4 1085 46 in in IN cord-009571-mygj2nd4 1085 47 human human JJ cord-009571-mygj2nd4 1085 48 synovial synovial JJ cord-009571-mygj2nd4 1085 49 cells cell NNS cord-009571-mygj2nd4 1085 50 ( ( -LRB- cord-009571-mygj2nd4 1085 51 SC SC NNP cord-009571-mygj2nd4 1085 52 ) ) -RRB- cord-009571-mygj2nd4 1085 53 . . . cord-009571-mygj2nd4 1086 1 Therefore therefore RB cord-009571-mygj2nd4 1086 2 , , , cord-009571-mygj2nd4 1086 3 we -PRON- PRP cord-009571-mygj2nd4 1086 4 investigated investigate VBD cord-009571-mygj2nd4 1086 5 the the DT cord-009571-mygj2nd4 1086 6 rates rate NNS cord-009571-mygj2nd4 1086 7 of of IN cord-009571-mygj2nd4 1086 8 pinocytosis pinocytosis NN cord-009571-mygj2nd4 1086 9 and and CC cord-009571-mygj2nd4 1086 10 intracellular intracellular JJ cord-009571-mygj2nd4 1086 11 digestion digestion NN cord-009571-mygj2nd4 1086 12 of of IN cord-009571-mygj2nd4 1086 13 a a DT cord-009571-mygj2nd4 1086 14 soluble soluble JJ cord-009571-mygj2nd4 1086 15 protein protein NN cord-009571-mygj2nd4 1086 16 , , , cord-009571-mygj2nd4 1086 17 horseradish horseradish NN cord-009571-mygj2nd4 1086 18 peroxidase peroxidase NN cord-009571-mygj2nd4 1086 19 ( ( -LRB- cord-009571-mygj2nd4 1086 20 HRP HRP NNP cord-009571-mygj2nd4 1086 21 ) ) -RRB- cord-009571-mygj2nd4 1086 22 , , , cord-009571-mygj2nd4 1086 23 in in IN cord-009571-mygj2nd4 1086 24 monolayers monolayer NNS cord-009571-mygj2nd4 1086 25 ( ( -LRB- cord-009571-mygj2nd4 1086 26 4 4 CD cord-009571-mygj2nd4 1086 27 - - SYM cord-009571-mygj2nd4 1086 28 15 15 CD cord-009571-mygj2nd4 1086 29 days day NNS cord-009571-mygj2nd4 1086 30 in in IN cord-009571-mygj2nd4 1086 31 primary primary JJ cord-009571-mygj2nd4 1086 32 culture culture NN cord-009571-mygj2nd4 1086 33 ) ) -RRB- cord-009571-mygj2nd4 1086 34 of of IN cord-009571-mygj2nd4 1086 35 SC SC NNP cord-009571-mygj2nd4 1086 36 from from IN cord-009571-mygj2nd4 1086 37 RA RA NNP cord-009571-mygj2nd4 1086 38 and and CC cord-009571-mygj2nd4 1086 39 non non JJ cord-009571-mygj2nd4 1086 40 - - JJ cord-009571-mygj2nd4 1086 41 RA ra JJ cord-009571-mygj2nd4 1086 42 patients patient NNS cord-009571-mygj2nd4 1086 43 . . . cord-009571-mygj2nd4 1087 1 Pinocytosis Pinocytosis NNP cord-009571-mygj2nd4 1087 2 was be VBD cord-009571-mygj2nd4 1087 3 linear linear JJ cord-009571-mygj2nd4 1087 4 with with IN cord-009571-mygj2nd4 1087 5 increasing increase VBG cord-009571-mygj2nd4 1087 6 H h NN cord-009571-mygj2nd4 1087 7 R r NN cord-009571-mygj2nd4 1087 8 P p NN cord-009571-mygj2nd4 1087 9 concentrations concentration NNS cord-009571-mygj2nd4 1087 10 ( ( -LRB- cord-009571-mygj2nd4 1087 11 0.01 0.01 CD cord-009571-mygj2nd4 1087 12 - - SYM cord-009571-mygj2nd4 1087 13 10 10 CD cord-009571-mygj2nd4 1087 14 mg mg NNP cord-009571-mygj2nd4 1087 15 / / SYM cord-009571-mygj2nd4 1087 16 ml ml NNP cord-009571-mygj2nd4 1087 17 ) ) -RRB- cord-009571-mygj2nd4 1087 18 , , , cord-009571-mygj2nd4 1087 19 time time NN cord-009571-mygj2nd4 1087 20 ( ( -LRB- cord-009571-mygj2nd4 1087 21 30 30 CD cord-009571-mygj2nd4 1087 22 - - SYM cord-009571-mygj2nd4 1087 23 120 120 CD cord-009571-mygj2nd4 1087 24 min min NN cord-009571-mygj2nd4 1087 25 ) ) -RRB- cord-009571-mygj2nd4 1087 26 , , , cord-009571-mygj2nd4 1087 27 cell cell NN cord-009571-mygj2nd4 1087 28 numbers number NNS cord-009571-mygj2nd4 1087 29 ( ( -LRB- cord-009571-mygj2nd4 1087 30 1 1 CD cord-009571-mygj2nd4 1087 31 - - SYM cord-009571-mygj2nd4 1087 32 10 10 CD cord-009571-mygj2nd4 1087 33 X x SYM cord-009571-mygj2nd4 1087 34 106 106 CD cord-009571-mygj2nd4 1087 35 ) ) -RRB- cord-009571-mygj2nd4 1087 36 and and CC cord-009571-mygj2nd4 1087 37 cell cell NN cord-009571-mygj2nd4 1087 38 protein protein NN cord-009571-mygj2nd4 1087 39 ( ( -LRB- cord-009571-mygj2nd4 1087 40 50-lo00 50-lo00 CD cord-009571-mygj2nd4 1087 41 pg pg NNP cord-009571-mygj2nd4 1087 42 ; ; : cord-009571-mygj2nd4 1087 43 5 5 CD cord-009571-mygj2nd4 1087 44 X x NN cord-009571-mygj2nd4 1087 45 I@ I@ NNS cord-009571-mygj2nd4 1087 46 cells cell NNS cord-009571-mygj2nd4 1087 47 equivalent equivalent JJ cord-009571-mygj2nd4 1087 48 to to IN cord-009571-mygj2nd4 1087 49 lOOpg loopg JJ cord-009571-mygj2nd4 1087 50 protein protein NN cord-009571-mygj2nd4 1087 51 ) ) -RRB- cord-009571-mygj2nd4 1087 52 . . . cord-009571-mygj2nd4 1088 1 Specific specific JJ cord-009571-mygj2nd4 1088 2 activity activity NN cord-009571-mygj2nd4 1088 3 ( ( -LRB- cord-009571-mygj2nd4 1088 4 SA sa NN cord-009571-mygj2nd4 1088 5 ; ; : cord-009571-mygj2nd4 1089 1 ng ng NNP cord-009571-mygj2nd4 1089 2 H h NN cord-009571-mygj2nd4 1089 3 R r NN cord-009571-mygj2nd4 1089 4 P p NN cord-009571-mygj2nd4 1089 5 taken take VBN cord-009571-mygj2nd4 1089 6 up/100 up/100 NNS cord-009571-mygj2nd4 1089 7 pg pg NNP cord-009571-mygj2nd4 1089 8 cell cell NN cord-009571-mygj2nd4 1089 9 protein/2 protein/2 NNP cord-009571-mygj2nd4 1089 10 hr hr NNP cord-009571-mygj2nd4 1089 11 ) ) -RRB- cord-009571-mygj2nd4 1090 1 increased increase VBN cord-009571-mygj2nd4 1090 2 in in IN cord-009571-mygj2nd4 1090 3 direct direct JJ cord-009571-mygj2nd4 1090 4 proportion proportion NN cord-009571-mygj2nd4 1090 5 to to IN cord-009571-mygj2nd4 1090 6 cell cell NN cord-009571-mygj2nd4 1090 7 concentration concentration NN cord-009571-mygj2nd4 1090 8 . . . cord-009571-mygj2nd4 1091 1 SA SA NNP cord-009571-mygj2nd4 1091 2 of of IN cord-009571-mygj2nd4 1091 3 R R NNP cord-009571-mygj2nd4 1091 4 A A NNP cord-009571-mygj2nd4 1091 5 cultures culture NNS cord-009571-mygj2nd4 1091 6 ( ( -LRB- cord-009571-mygj2nd4 1091 7 100 100 CD cord-009571-mygj2nd4 1091 8 - - SYM cord-009571-mygj2nd4 1091 9 200 200 CD cord-009571-mygj2nd4 1091 10 pg pg NN cord-009571-mygj2nd4 1091 11 protein protein NN cord-009571-mygj2nd4 1091 12 ) ) -RRB- cord-009571-mygj2nd4 1092 1 after after IN cord-009571-mygj2nd4 1092 2 exposure exposure NN cord-009571-mygj2nd4 1092 3 to to IN cord-009571-mygj2nd4 1092 4 1 1 CD cord-009571-mygj2nd4 1092 5 mg mg NNP cord-009571-mygj2nd4 1092 6 / / SYM cord-009571-mygj2nd4 1092 7 ml ml NN cord-009571-mygj2nd4 1092 8 H h NN cord-009571-mygj2nd4 1092 9 R r NN cord-009571-mygj2nd4 1092 10 P p NN cord-009571-mygj2nd4 1092 11 was be VBD cord-009571-mygj2nd4 1092 12 270 270 CD cord-009571-mygj2nd4 1092 13 f f NN cord-009571-mygj2nd4 1092 14 182 182 CD cord-009571-mygj2nd4 1092 15 ( ( -LRB- cord-009571-mygj2nd4 1092 16 mean mean VB cord-009571-mygj2nd4 1092 17 f f NNP cord-009571-mygj2nd4 1092 18 SD sd NN cord-009571-mygj2nd4 1092 19 ; ; : cord-009571-mygj2nd4 1092 20 n n NN cord-009571-mygj2nd4 1092 21 = = SYM cord-009571-mygj2nd4 1092 22 5 5 CD cord-009571-mygj2nd4 1092 23 ) ) -RRB- cord-009571-mygj2nd4 1092 24 ; ; : cord-009571-mygj2nd4 1092 25 an an DT cord-009571-mygj2nd4 1092 26 equivalent equivalent JJ cord-009571-mygj2nd4 1092 27 concentration concentration NN cord-009571-mygj2nd4 1092 28 of of IN cord-009571-mygj2nd4 1092 29 non non JJ cord-009571-mygj2nd4 1092 30 - - JJ cord-009571-mygj2nd4 1092 31 RA RA NNP cord-009571-mygj2nd4 1092 32 SC SC NNP cord-009571-mygj2nd4 1092 33 had have VBD cord-009571-mygj2nd4 1092 34 a a DT cord-009571-mygj2nd4 1092 35 SA SA NNP cord-009571-mygj2nd4 1092 36 of of IN cord-009571-mygj2nd4 1092 37 142 142 CD cord-009571-mygj2nd4 1092 38 f f NNP cord-009571-mygj2nd4 1092 39 90 90 CD cord-009571-mygj2nd4 1092 40 ( ( -LRB- cord-009571-mygj2nd4 1092 41 n n NN cord-009571-mygj2nd4 1092 42 = = SYM cord-009571-mygj2nd4 1092 43 5 5 CD cord-009571-mygj2nd4 1092 44 ) ) -RRB- cord-009571-mygj2nd4 1092 45 . . . cord-009571-mygj2nd4 1093 1 Uptake uptake NN cord-009571-mygj2nd4 1093 2 in in IN cord-009571-mygj2nd4 1093 3 both both DT cord-009571-mygj2nd4 1093 4 R R NNP cord-009571-mygj2nd4 1093 5 A a NN cord-009571-mygj2nd4 1093 6 and and CC cord-009571-mygj2nd4 1093 7 non non JJ cord-009571-mygj2nd4 1093 8 - - JJ cord-009571-mygj2nd4 1093 9 RA RA NNP cord-009571-mygj2nd4 1093 10 SC SC NNP cord-009571-mygj2nd4 1093 11 was be VBD cord-009571-mygj2nd4 1093 12 inhibited inhibit VBN cord-009571-mygj2nd4 1093 13 most most RBS cord-009571-mygj2nd4 1093 14 effectively effectively RB cord-009571-mygj2nd4 1093 15 by by IN cord-009571-mygj2nd4 1093 16 10 10 CD cord-009571-mygj2nd4 1093 17 - - SYM cord-009571-mygj2nd4 1093 18 3 3 CD cord-009571-mygj2nd4 1093 19 M m NN cord-009571-mygj2nd4 1093 20 potassium potassium NN cord-009571-mygj2nd4 1093 21 fluoride fluoride NN cord-009571-mygj2nd4 1093 22 ( ( -LRB- cord-009571-mygj2nd4 1093 23 80 80 CD cord-009571-mygj2nd4 1093 24 % % NN cord-009571-mygj2nd4 1093 25 ) ) -RRB- cord-009571-mygj2nd4 1093 26 and and CC cord-009571-mygj2nd4 1093 27 4 4 CD cord-009571-mygj2nd4 1093 28 ° ° NN cord-009571-mygj2nd4 1093 29 C c NN cord-009571-mygj2nd4 1093 30 ( ( -LRB- cord-009571-mygj2nd4 1093 31 98 98 CD cord-009571-mygj2nd4 1093 32 % % NN cord-009571-mygj2nd4 1093 33 ) ) -RRB- cord-009571-mygj2nd4 1093 34 . . . cord-009571-mygj2nd4 1094 1 R R NNP cord-009571-mygj2nd4 1094 2 A a DT cord-009571-mygj2nd4 1094 3 SC SC NNP cord-009571-mygj2nd4 1094 4 digested digest VBD cord-009571-mygj2nd4 1094 5 50 50 CD cord-009571-mygj2nd4 1094 6 % % NN cord-009571-mygj2nd4 1094 7 of of IN cord-009571-mygj2nd4 1094 8 cell cell NN cord-009571-mygj2nd4 1094 9 bound bind VBN cord-009571-mygj2nd4 1094 10 H h NN cord-009571-mygj2nd4 1094 11 R r NN cord-009571-mygj2nd4 1094 12 P p NN cord-009571-mygj2nd4 1094 13 ( ( -LRB- cord-009571-mygj2nd4 1094 14 T% T% NNP cord-009571-mygj2nd4 1094 15 ) ) -RRB- cord-009571-mygj2nd4 1094 16 in in IN cord-009571-mygj2nd4 1094 17 6 6 CD cord-009571-mygj2nd4 1094 18 hours hour NNS cord-009571-mygj2nd4 1094 19 , , , cord-009571-mygj2nd4 1094 20 whereas whereas IN cord-009571-mygj2nd4 1094 21 T% T% NNP cord-009571-mygj2nd4 1094 22 for for IN cord-009571-mygj2nd4 1094 23 non non JJ cord-009571-mygj2nd4 1094 24 - - JJ cord-009571-mygj2nd4 1094 25 RA RA NNP cord-009571-mygj2nd4 1094 26 SC SC NNP cord-009571-mygj2nd4 1094 27 was be VBD cord-009571-mygj2nd4 1094 28 13 13 CD cord-009571-mygj2nd4 1094 29 hours hour NNS cord-009571-mygj2nd4 1094 30 . . . cord-009571-mygj2nd4 1095 1 Uptake uptake NN cord-009571-mygj2nd4 1095 2 and and CC cord-009571-mygj2nd4 1095 3 digestion digestion NN cord-009571-mygj2nd4 1095 4 of of IN cord-009571-mygj2nd4 1095 5 immune immune JJ cord-009571-mygj2nd4 1095 6 complexes complex NNS cord-009571-mygj2nd4 1095 7 by by IN cord-009571-mygj2nd4 1095 8 RA RA NNP cord-009571-mygj2nd4 1095 9 SC SC NNP cord-009571-mygj2nd4 1095 10 were be VBD cord-009571-mygj2nd4 1095 11 also also RB cord-009571-mygj2nd4 1095 12 studied study VBN cord-009571-mygj2nd4 1095 13 . . . cord-009571-mygj2nd4 1096 1 Insoluble insoluble JJ cord-009571-mygj2nd4 1096 2 HRP HRP NNP cord-009571-mygj2nd4 1096 3 - - HYPH cord-009571-mygj2nd4 1096 4 anti anti NN cord-009571-mygj2nd4 1096 5 H h NN cord-009571-mygj2nd4 1096 6 R r NN cord-009571-mygj2nd4 1096 7 P p NN cord-009571-mygj2nd4 1096 8 complexes complex NNS cord-009571-mygj2nd4 1096 9 formed form VBN cord-009571-mygj2nd4 1096 10 at at IN cord-009571-mygj2nd4 1096 11 equivalence equivalence NN cord-009571-mygj2nd4 1096 12 were be VBD cord-009571-mygj2nd4 1096 13 added add VBN cord-009571-mygj2nd4 1096 14 to to IN cord-009571-mygj2nd4 1096 15 SC SC NNP cord-009571-mygj2nd4 1096 16 at at IN cord-009571-mygj2nd4 1096 17 1.25 1.25 CD cord-009571-mygj2nd4 1096 18 pg pg NN cord-009571-mygj2nd4 1096 19 HRP HRP NNP cord-009571-mygj2nd4 1096 20 / / SYM cord-009571-mygj2nd4 1096 21 ml ml NNP cord-009571-mygj2nd4 1096 22 ( ( -LRB- cord-009571-mygj2nd4 1096 23 total total JJ cord-009571-mygj2nd4 1096 24 protein protein NN cord-009571-mygj2nd4 1096 25 concentration concentration NN cord-009571-mygj2nd4 1096 26 12.5 12.5 CD cord-009571-mygj2nd4 1096 27 pg pg NNP cord-009571-mygj2nd4 1096 28 / / SYM cord-009571-mygj2nd4 1096 29 ml ml NNP cord-009571-mygj2nd4 1096 30 ) ) -RRB- cord-009571-mygj2nd4 1096 31 . . . cord-009571-mygj2nd4 1097 1 Uptake uptake NN cord-009571-mygj2nd4 1097 2 of of IN cord-009571-mygj2nd4 1097 3 complexed complexed JJ cord-009571-mygj2nd4 1097 4 H h NN cord-009571-mygj2nd4 1097 5 R r NN cord-009571-mygj2nd4 1097 6 P p NN cord-009571-mygj2nd4 1097 7 was be VBD cord-009571-mygj2nd4 1097 8 at at IN cord-009571-mygj2nd4 1097 9 a a DT cord-009571-mygj2nd4 1097 10 rate rate NN cord-009571-mygj2nd4 1097 11 ( ( -LRB- cord-009571-mygj2nd4 1097 12 4.8 4.8 CD cord-009571-mygj2nd4 1097 13 % % NN cord-009571-mygj2nd4 1097 14 of of IN cord-009571-mygj2nd4 1097 15 this this DT cord-009571-mygj2nd4 1097 16 load/100 load/100 NN cord-009571-mygj2nd4 1097 17 pg pg NNP cord-009571-mygj2nd4 1097 18 cell cell NN cord-009571-mygj2nd4 1097 19 protein protein NNP cord-009571-mygj2nd4 1097 20 / / SYM cord-009571-mygj2nd4 1097 21 hr hr NN cord-009571-mygj2nd4 1097 22 . . . cord-009571-mygj2nd4 1097 23 ) ) -RRB- cord-009571-mygj2nd4 1098 1 approximately approximately RB cord-009571-mygj2nd4 1098 2 600 600 CD cord-009571-mygj2nd4 1098 3 times time NNS cord-009571-mygj2nd4 1098 4 that that IN cord-009571-mygj2nd4 1098 5 for for IN cord-009571-mygj2nd4 1098 6 soluble soluble JJ cord-009571-mygj2nd4 1098 7 H h NN cord-009571-mygj2nd4 1098 8 R r NN cord-009571-mygj2nd4 1098 9 P p NN cord-009571-mygj2nd4 1098 10 ( ( -LRB- cord-009571-mygj2nd4 1098 11 at at IN cord-009571-mygj2nd4 1098 12 a a DT cord-009571-mygj2nd4 1098 13 load load NN cord-009571-mygj2nd4 1098 14 of of IN cord-009571-mygj2nd4 1098 15 1 1 CD cord-009571-mygj2nd4 1098 16 mg/ mg/ NN cord-009571-mygj2nd4 1098 17 ml ml NN cord-009571-mygj2nd4 1098 18 ) ) -RRB- cord-009571-mygj2nd4 1098 19 . . . cord-009571-mygj2nd4 1099 1 Only only RB cord-009571-mygj2nd4 1099 2 16 16 CD cord-009571-mygj2nd4 1099 3 % % NN cord-009571-mygj2nd4 1099 4 of of IN cord-009571-mygj2nd4 1099 5 complexed complexed JJ cord-009571-mygj2nd4 1099 6 H h NN cord-009571-mygj2nd4 1099 7 R r NN cord-009571-mygj2nd4 1099 8 P p NN cord-009571-mygj2nd4 1099 9 was be VBD cord-009571-mygj2nd4 1099 10 digested digest VBN cord-009571-mygj2nd4 1099 11 by by IN cord-009571-mygj2nd4 1099 12 24 24 CD cord-009571-mygj2nd4 1099 13 hours hour NNS cord-009571-mygj2nd4 1099 14 . . . cord-009571-mygj2nd4 1100 1 These these DT cord-009571-mygj2nd4 1100 2 studies study NNS cord-009571-mygj2nd4 1100 3 indicate indicate VBP cord-009571-mygj2nd4 1100 4 : : : cord-009571-mygj2nd4 1100 5 1 1 LS cord-009571-mygj2nd4 1100 6 ) ) -RRB- cord-009571-mygj2nd4 1100 7 human human JJ cord-009571-mygj2nd4 1100 8 SC SC NNP cord-009571-mygj2nd4 1100 9 have have VBP cord-009571-mygj2nd4 1100 10 a a DT cord-009571-mygj2nd4 1100 11 relatively relatively RB cord-009571-mygj2nd4 1100 12 high high JJ cord-009571-mygj2nd4 1100 13 rate rate NN cord-009571-mygj2nd4 1100 14 of of IN cord-009571-mygj2nd4 1100 15 pinocytosis pinocytosis NN cord-009571-mygj2nd4 1100 16 and and CC cord-009571-mygj2nd4 1100 17 R R NNP cord-009571-mygj2nd4 1100 18 A a DT cord-009571-mygj2nd4 1100 19 SC SC NNP cord-009571-mygj2nd4 1100 20 demonstrate demonstrate VBP cord-009571-mygj2nd4 1100 21 the the DT cord-009571-mygj2nd4 1100 22 greatest great JJS cord-009571-mygj2nd4 1100 23 rates rate NNS cord-009571-mygj2nd4 1100 24 of of IN cord-009571-mygj2nd4 1100 25 uptake uptake NN cord-009571-mygj2nd4 1100 26 ; ; : cord-009571-mygj2nd4 1100 27 2 2 LS cord-009571-mygj2nd4 1100 28 ) ) -RRB- cord-009571-mygj2nd4 1100 29 kinetics kinetic NNS cord-009571-mygj2nd4 1100 30 of of IN cord-009571-mygj2nd4 1100 31 pinocytosis pinocytosis NNP cord-009571-mygj2nd4 1100 32 in in IN cord-009571-mygj2nd4 1100 33 SC SC NNP cord-009571-mygj2nd4 1100 34 are be VBP cord-009571-mygj2nd4 1100 35 primarily primarily RB cord-009571-mygj2nd4 1100 36 those those DT cord-009571-mygj2nd4 1100 37 of of IN cord-009571-mygj2nd4 1100 38 fluid fluid JJ cord-009571-mygj2nd4 1100 39 phase phase NN cord-009571-mygj2nd4 1100 40 uptake uptake NN cord-009571-mygj2nd4 1100 41 ; ; : cord-009571-mygj2nd4 1100 42 3 3 LS cord-009571-mygj2nd4 1100 43 ) ) -RRB- cord-009571-mygj2nd4 1100 44 the the DT cord-009571-mygj2nd4 1100 45 rate rate NN cord-009571-mygj2nd4 1100 46 of of IN cord-009571-mygj2nd4 1100 47 pinocytosis pinocytosis NN cord-009571-mygj2nd4 1100 48 increases increase NNS cord-009571-mygj2nd4 1100 49 with with IN cord-009571-mygj2nd4 1100 50 increased increase VBN cord-009571-mygj2nd4 1100 51 cell cell NN cord-009571-mygj2nd4 1100 52 density density NN cord-009571-mygj2nd4 1100 53 , , , cord-009571-mygj2nd4 1100 54 a a DT cord-009571-mygj2nd4 1100 55 relation relation NN cord-009571-mygj2nd4 1100 56 which which WDT cord-009571-mygj2nd4 1100 57 may may MD cord-009571-mygj2nd4 1100 58 be be VB cord-009571-mygj2nd4 1100 59 important important JJ cord-009571-mygj2nd4 1100 60 in in IN cord-009571-mygj2nd4 1100 61 RA RA NNP cord-009571-mygj2nd4 1100 62 synovial synovial JJ cord-009571-mygj2nd4 1100 63 tissue tissue NN cord-009571-mygj2nd4 1100 64 ; ; : cord-009571-mygj2nd4 1100 65 4 4 LS cord-009571-mygj2nd4 1100 66 ) ) -RRB- cord-009571-mygj2nd4 1100 67 R r NN cord-009571-mygj2nd4 1100 68 A a DT cord-009571-mygj2nd4 1100 69 SC SC NNP cord-009571-mygj2nd4 1100 70 can can MD cord-009571-mygj2nd4 1100 71 readily readily RB cord-009571-mygj2nd4 1100 72 accumulate accumulate VB cord-009571-mygj2nd4 1100 73 immune immune JJ cord-009571-mygj2nd4 1100 74 complexes complex NNS cord-009571-mygj2nd4 1100 75 , , , cord-009571-mygj2nd4 1100 76 but but CC cord-009571-mygj2nd4 1100 77 their -PRON- PRP$ cord-009571-mygj2nd4 1100 78 ability ability NN cord-009571-mygj2nd4 1100 79 to to TO cord-009571-mygj2nd4 1100 80 digest digest VB cord-009571-mygj2nd4 1100 81 them -PRON- PRP cord-009571-mygj2nd4 1100 82 is be VBZ cord-009571-mygj2nd4 1100 83 much much RB cord-009571-mygj2nd4 1100 84 more more RBR cord-009571-mygj2nd4 1100 85 limited limited JJ cord-009571-mygj2nd4 1100 86 than than IN cord-009571-mygj2nd4 1100 87 it -PRON- PRP cord-009571-mygj2nd4 1100 88 is be VBZ cord-009571-mygj2nd4 1100 89 for for IN cord-009571-mygj2nd4 1100 90 soluble soluble JJ cord-009571-mygj2nd4 1100 91 proteins protein NNS cord-009571-mygj2nd4 1100 92 . . . cord-009571-mygj2nd4 1101 1 Further further JJ cord-009571-mygj2nd4 1101 2 quantitative quantitative JJ cord-009571-mygj2nd4 1101 3 studies study NNS cord-009571-mygj2nd4 1101 4 of of IN cord-009571-mygj2nd4 1101 5 the the DT cord-009571-mygj2nd4 1101 6 mechanisms mechanism NNS cord-009571-mygj2nd4 1101 7 whereby whereby WRB cord-009571-mygj2nd4 1101 8 SC SC NNP cord-009571-mygj2nd4 1101 9 process process NN cord-009571-mygj2nd4 1101 10 joint joint JJ cord-009571-mygj2nd4 1101 11 constituents constituent NNS cord-009571-mygj2nd4 1101 12 , , , cord-009571-mygj2nd4 1101 13 soluble soluble JJ cord-009571-mygj2nd4 1101 14 antigens antigen NNS cord-009571-mygj2nd4 1101 15 and and CC cord-009571-mygj2nd4 1101 16 immune immune JJ cord-009571-mygj2nd4 1101 17 complexes complex NNS cord-009571-mygj2nd4 1101 18 should should MD cord-009571-mygj2nd4 1101 19 lead lead VB cord-009571-mygj2nd4 1101 20 to to IN cord-009571-mygj2nd4 1101 21 a a DT cord-009571-mygj2nd4 1101 22 more more RBR cord-009571-mygj2nd4 1101 23 precise precise JJ cord-009571-mygj2nd4 1101 24 definition definition NN cord-009571-mygj2nd4 1101 25 of of IN cord-009571-mygj2nd4 1101 26 the the DT cord-009571-mygj2nd4 1101 27 contribution contribution NN cord-009571-mygj2nd4 1101 28 of of IN cord-009571-mygj2nd4 1101 29 SC SC NNP cord-009571-mygj2nd4 1101 30 endocyticlysosomal endocyticlysosomal NNP cord-009571-mygj2nd4 1101 31 functions function NNS cord-009571-mygj2nd4 1101 32 to to TO cord-009571-mygj2nd4 1101 33 tissue tissue VB cord-009571-mygj2nd4 1101 34 injury injury NN cord-009571-mygj2nd4 1101 35 in in IN cord-009571-mygj2nd4 1101 36 RA RA NNP cord-009571-mygj2nd4 1101 37 . . . cord-009571-mygj2nd4 1102 1 This this DT cord-009571-mygj2nd4 1102 2 study study NN cord-009571-mygj2nd4 1102 3 was be VBD cord-009571-mygj2nd4 1102 4 designed design VBN cord-009571-mygj2nd4 1102 5 t t NNP cord-009571-mygj2nd4 1102 6 o o UH cord-009571-mygj2nd4 1102 7 evaluate evaluate VB cord-009571-mygj2nd4 1102 8 the the DT cord-009571-mygj2nd4 1102 9 effects effect NNS cord-009571-mygj2nd4 1102 10 of of IN cord-009571-mygj2nd4 1102 11 several several JJ cord-009571-mygj2nd4 1102 12 nonsteroidal nonsteroidal JJ cord-009571-mygj2nd4 1102 13 antiinflammatory antiinflammatory JJ cord-009571-mygj2nd4 1102 14 drugs drug NNS cord-009571-mygj2nd4 1102 15 commonly commonly RB cord-009571-mygj2nd4 1102 16 used use VBN cord-009571-mygj2nd4 1102 17 in in IN cord-009571-mygj2nd4 1102 18 arthritis arthritis NN cord-009571-mygj2nd4 1102 19 therapy therapy NN cord-009571-mygj2nd4 1102 20 on on IN cord-009571-mygj2nd4 1102 21 gastric gastric JJ cord-009571-mygj2nd4 1102 22 mucosa mucosa NN cord-009571-mygj2nd4 1102 23 , , , cord-009571-mygj2nd4 1102 24 and and CC cord-009571-mygj2nd4 1102 25 to to TO cord-009571-mygj2nd4 1102 26 evaluate evaluate VB cord-009571-mygj2nd4 1102 27 the the DT cord-009571-mygj2nd4 1102 28 effects effect NNS cord-009571-mygj2nd4 1102 29 of of IN cord-009571-mygj2nd4 1102 30 2 2 CD cord-009571-mygj2nd4 1102 31 agents agent NNS cord-009571-mygj2nd4 1102 32 , , , cord-009571-mygj2nd4 1102 33 Tolectin Tolectin NNP cord-009571-mygj2nd4 1102 34 and and CC cord-009571-mygj2nd4 1102 35 Motrin Motrin NNP cord-009571-mygj2nd4 1102 36 , , , cord-009571-mygj2nd4 1102 37 in in IN cord-009571-mygj2nd4 1102 38 subjects subject NNS cord-009571-mygj2nd4 1102 39 with with IN cord-009571-mygj2nd4 1102 40 demonstrated demonstrate VBN cord-009571-mygj2nd4 1102 41 clinical clinical JJ cord-009571-mygj2nd4 1102 42 intolerance intolerance NN cord-009571-mygj2nd4 1102 43 to to IN cord-009571-mygj2nd4 1102 44 aspirin aspirin NN cord-009571-mygj2nd4 1102 45 . . . cord-009571-mygj2nd4 1103 1 Gastroscopy Gastroscopy NNP cord-009571-mygj2nd4 1103 2 was be VBD cord-009571-mygj2nd4 1103 3 carried carry VBN cord-009571-mygj2nd4 1103 4 out out RP cord-009571-mygj2nd4 1103 5 before before RB cord-009571-mygj2nd4 1103 6 and and CC cord-009571-mygj2nd4 1103 7 after after IN cord-009571-mygj2nd4 1103 8 all all DT cord-009571-mygj2nd4 1103 9 treatment treatment NN cord-009571-mygj2nd4 1103 10 schedules schedule NNS cord-009571-mygj2nd4 1103 11 , , , cord-009571-mygj2nd4 1103 12 and and CC cord-009571-mygj2nd4 1103 13 gastric gastric JJ cord-009571-mygj2nd4 1103 14 mucosa mucosa NN cord-009571-mygj2nd4 1103 15 was be VBD cord-009571-mygj2nd4 1103 16 graded grade VBN cord-009571-mygj2nd4 1103 17 by by IN cord-009571-mygj2nd4 1103 18 the the DT cord-009571-mygj2nd4 1103 19 endoscopist endoscopist NN cord-009571-mygj2nd4 1103 20 ( ( -LRB- cord-009571-mygj2nd4 1103 21 FL FL NNP cord-009571-mygj2nd4 1103 22 ) ) -RRB- cord-009571-mygj2nd4 1103 23 on on IN cord-009571-mygj2nd4 1103 24 a a DT cord-009571-mygj2nd4 1103 25 scale scale NN cord-009571-mygj2nd4 1103 26 of of IN cord-009571-mygj2nd4 1103 27 0 0 CD cord-009571-mygj2nd4 1103 28 - - SYM cord-009571-mygj2nd4 1103 29 4 4 CD cord-009571-mygj2nd4 1104 1 + + UH cord-009571-mygj2nd4 1104 2 . . . cord-009571-mygj2nd4 1105 1 Photographs photograph NNS cord-009571-mygj2nd4 1105 2 were be VBD cord-009571-mygj2nd4 1105 3 taken take VBN cord-009571-mygj2nd4 1105 4 and and CC cord-009571-mygj2nd4 1105 5 subsequently subsequently RB cord-009571-mygj2nd4 1105 6 reviewed review VBN cord-009571-mygj2nd4 1105 7 in in IN cord-009571-mygj2nd4 1105 8 a a DT cord-009571-mygj2nd4 1105 9 randomized randomized JJ cord-009571-mygj2nd4 1105 10 double double JJ cord-009571-mygj2nd4 1105 11 - - HYPH cord-009571-mygj2nd4 1105 12 blind blind JJ cord-009571-mygj2nd4 1105 13 manner manner NN cord-009571-mygj2nd4 1105 14 by by IN cord-009571-mygj2nd4 1105 15 both both CC cord-009571-mygj2nd4 1105 16 the the DT cord-009571-mygj2nd4 1105 17 endoscopist endoscopist NN cord-009571-mygj2nd4 1105 18 ( ( -LRB- cord-009571-mygj2nd4 1105 19 FL FL NNP cord-009571-mygj2nd4 1105 20 ) ) -RRB- cord-009571-mygj2nd4 1105 21 and and CC cord-009571-mygj2nd4 1105 22 an an DT cord-009571-mygj2nd4 1105 23 impartial impartial JJ cord-009571-mygj2nd4 1105 24 gastroenterologist gastroenterologist NN cord-009571-mygj2nd4 1105 25 ( ( -LRB- cord-009571-mygj2nd4 1105 26 RN RN NNP cord-009571-mygj2nd4 1105 27 ) ) -RRB- cord-009571-mygj2nd4 1105 28 . . . cord-009571-mygj2nd4 1106 1 Remarkably remarkably RB cord-009571-mygj2nd4 1106 2 consistent consistent JJ cord-009571-mygj2nd4 1106 3 results result NNS cord-009571-mygj2nd4 1106 4 were be VBD cord-009571-mygj2nd4 1106 5 obtained obtain VBN cord-009571-mygj2nd4 1106 6 : : : cord-009571-mygj2nd4 1107 1 Part part NN cord-009571-mygj2nd4 1107 2 I. I. NNP cord-009571-mygj2nd4 1107 3 Forty Forty NNP cord-009571-mygj2nd4 1107 4 volunteers volunteer NNS cord-009571-mygj2nd4 1107 5 were be VBD cord-009571-mygj2nd4 1107 6 randomly randomly RB cord-009571-mygj2nd4 1107 7 divided divide VBN cord-009571-mygj2nd4 1107 8 into into IN cord-009571-mygj2nd4 1107 9 8 8 CD cord-009571-mygj2nd4 1107 10 groups group NNS cord-009571-mygj2nd4 1107 11 with with IN cord-009571-mygj2nd4 1107 12 5 5 CD cord-009571-mygj2nd4 1107 13 subjects subject NNS cord-009571-mygj2nd4 1107 14 in in IN cord-009571-mygj2nd4 1107 15 each each DT cord-009571-mygj2nd4 1107 16 group group NN cord-009571-mygj2nd4 1107 17 and and CC cord-009571-mygj2nd4 1107 18 treated treat VBD cord-009571-mygj2nd4 1107 19 for for IN cord-009571-mygj2nd4 1107 20 1 1 CD cord-009571-mygj2nd4 1107 21 week week NN cord-009571-mygj2nd4 1107 22 with with IN cord-009571-mygj2nd4 1107 23 either either CC cord-009571-mygj2nd4 1107 24 Motrin Motrin NNP cord-009571-mygj2nd4 1107 25 ( ( -LRB- cord-009571-mygj2nd4 1107 26 2400 2400 CD cord-009571-mygj2nd4 1107 27 mg mg NNP cord-009571-mygj2nd4 1107 28 / / SYM cord-009571-mygj2nd4 1107 29 day day NN cord-009571-mygj2nd4 1107 30 ) ) -RRB- cord-009571-mygj2nd4 1107 31 , , , cord-009571-mygj2nd4 1107 32 Motrin Motrin NNP cord-009571-mygj2nd4 1107 33 ( ( -LRB- cord-009571-mygj2nd4 1107 34 1600 1600 CD cord-009571-mygj2nd4 1107 35 mg mg NNP cord-009571-mygj2nd4 1107 36 / / SYM cord-009571-mygj2nd4 1107 37 day day NN cord-009571-mygj2nd4 1107 38 ) ) -RRB- cord-009571-mygj2nd4 1107 39 , , , cord-009571-mygj2nd4 1107 40 Indocin Indocin NNP cord-009571-mygj2nd4 1107 41 ( ( -LRB- cord-009571-mygj2nd4 1107 42 1 1 CD cord-009571-mygj2nd4 1107 43 50 50 CD cord-009571-mygj2nd4 1107 44 mg mg NNP cord-009571-mygj2nd4 1107 45 / / SYM cord-009571-mygj2nd4 1107 46 day day NN cord-009571-mygj2nd4 1107 47 ) ) -RRB- cord-009571-mygj2nd4 1107 48 , , , cord-009571-mygj2nd4 1107 49 Indocin Indocin NNP cord-009571-mygj2nd4 1107 50 ( ( -LRB- cord-009571-mygj2nd4 1107 51 100 100 CD cord-009571-mygj2nd4 1107 52 mg mg NNP cord-009571-mygj2nd4 1107 53 / / SYM cord-009571-mygj2nd4 1107 54 day day NN cord-009571-mygj2nd4 1107 55 ) ) -RRB- cord-009571-mygj2nd4 1107 56 , , , cord-009571-mygj2nd4 1107 57 Naprosyn Naprosyn NNP cord-009571-mygj2nd4 1107 58 ( ( -LRB- cord-009571-mygj2nd4 1107 59 750 750 CD cord-009571-mygj2nd4 1107 60 mg mg NNP cord-009571-mygj2nd4 1107 61 / / SYM cord-009571-mygj2nd4 1107 62 day day NN cord-009571-mygj2nd4 1107 63 ) ) -RRB- cord-009571-mygj2nd4 1107 64 , , , cord-009571-mygj2nd4 1107 65 Naprosyn Naprosyn NNP cord-009571-mygj2nd4 1107 66 ( ( -LRB- cord-009571-mygj2nd4 1107 67 500 500 CD cord-009571-mygj2nd4 1107 68 mg mg NNP cord-009571-mygj2nd4 1107 69 / / SYM cord-009571-mygj2nd4 1107 70 day day NN cord-009571-mygj2nd4 1107 71 ) ) -RRB- cord-009571-mygj2nd4 1107 72 , , , cord-009571-mygj2nd4 1107 73 aspirin aspirin NN cord-009571-mygj2nd4 1107 74 ( ( -LRB- cord-009571-mygj2nd4 1107 75 3.6 3.6 CD cord-009571-mygj2nd4 1107 76 gm gm NNP cord-009571-mygj2nd4 1107 77 / / SYM cord-009571-mygj2nd4 1107 78 day day NN cord-009571-mygj2nd4 1107 79 ) ) -RRB- cord-009571-mygj2nd4 1107 80 , , , cord-009571-mygj2nd4 1107 81 and and CC cord-009571-mygj2nd4 1107 82 placebo placebo NN cord-009571-mygj2nd4 1107 83 . . . cord-009571-mygj2nd4 1108 1 Part part NN cord-009571-mygj2nd4 1108 2 11 11 CD cord-009571-mygj2nd4 1108 3 . . . cord-009571-mygj2nd4 1109 1 Five five CD cord-009571-mygj2nd4 1109 2 normal normal JJ cord-009571-mygj2nd4 1109 3 volunteers volunteer NNS cord-009571-mygj2nd4 1109 4 who who WP cord-009571-mygj2nd4 1109 5 had have VBD cord-009571-mygj2nd4 1109 6 developed develop VBN cord-009571-mygj2nd4 1109 7 4 4 CD cord-009571-mygj2nd4 1109 8 + + CD cord-009571-mygj2nd4 1109 9 hemorrhagic hemorrhagic JJ cord-009571-mygj2nd4 1109 10 gastritis gastritis NN cord-009571-mygj2nd4 1109 11 during during IN cord-009571-mygj2nd4 1109 12 a a DT cord-009571-mygj2nd4 1109 13 previous previous JJ cord-009571-mygj2nd4 1109 14 study study NN cord-009571-mygj2nd4 1109 15 after after IN cord-009571-mygj2nd4 1109 16 1 1 CD cord-009571-mygj2nd4 1109 17 week week NN cord-009571-mygj2nd4 1109 18 of of IN cord-009571-mygj2nd4 1109 19 aspirin aspirin NN cord-009571-mygj2nd4 1109 20 ( ( -LRB- cord-009571-mygj2nd4 1109 21 3.6 3.6 CD cord-009571-mygj2nd4 1109 22 gm gm NNP cord-009571-mygj2nd4 1109 23 / / SYM cord-009571-mygj2nd4 1109 24 day day NN cord-009571-mygj2nd4 1109 25 ) ) -RRB- cord-009571-mygj2nd4 1109 26 were be VBD cord-009571-mygj2nd4 1109 27 given give VBN cord-009571-mygj2nd4 1109 28 Motrin Motrin NNP cord-009571-mygj2nd4 1109 29 ( ( -LRB- cord-009571-mygj2nd4 1109 30 2400 2400 CD cord-009571-mygj2nd4 1109 31 gm gm NNP cord-009571-mygj2nd4 1109 32 / / SYM cord-009571-mygj2nd4 1109 33 day day NN cord-009571-mygj2nd4 1109 34 ) ) -RRB- cord-009571-mygj2nd4 1109 35 , , , cord-009571-mygj2nd4 1109 36 Tolectin Tolectin NNP cord-009571-mygj2nd4 1109 37 ( ( -LRB- cord-009571-mygj2nd4 1109 38 2000 2000 CD cord-009571-mygj2nd4 1109 39 mg mg NNP cord-009571-mygj2nd4 1109 40 / / SYM cord-009571-mygj2nd4 1109 41 day day NN cord-009571-mygj2nd4 1109 42 ) ) -RRB- cord-009571-mygj2nd4 1109 43 , , , cord-009571-mygj2nd4 1109 44 and and CC cord-009571-mygj2nd4 1109 45 placebo placebo NN cord-009571-mygj2nd4 1109 46 for for IN cord-009571-mygj2nd4 1109 47 1 1 CD cord-009571-mygj2nd4 1109 48 week week NN cord-009571-mygj2nd4 1109 49 in in IN cord-009571-mygj2nd4 1109 50 a a DT cord-009571-mygj2nd4 1109 51 randomized randomized JJ cord-009571-mygj2nd4 1109 52 crossover crossover NN cord-009571-mygj2nd4 1109 53 manner manner NN cord-009571-mygj2nd4 1109 54 with with IN cord-009571-mygj2nd4 1109 55 at at RB cord-009571-mygj2nd4 1109 56 least least JJS cord-009571-mygj2nd4 1109 57 a a DT cord-009571-mygj2nd4 1109 58 2-week 2-week CD cord-009571-mygj2nd4 1109 59 washout washout NN cord-009571-mygj2nd4 1109 60 between between IN cord-009571-mygj2nd4 1109 61 medications medication NNS cord-009571-mygj2nd4 1109 62 . . . cord-009571-mygj2nd4 1110 1 RESULTS result NNS cord-009571-mygj2nd4 1110 2 . . . cord-009571-mygj2nd4 1111 1 Part part NN cord-009571-mygj2nd4 1111 2 I. I. NNP cord-009571-mygj2nd4 1111 3 Placebo Placebo NNP cord-009571-mygj2nd4 1111 4 subjects subject NNS cord-009571-mygj2nd4 1111 5 always always RB cord-009571-mygj2nd4 1111 6 showed show VBD cord-009571-mygj2nd4 1111 7 the the DT cord-009571-mygj2nd4 1111 8 least least JJS cord-009571-mygj2nd4 1111 9 pathology pathology NN cord-009571-mygj2nd4 1111 10 followed follow VBN cord-009571-mygj2nd4 1111 11 by by IN cord-009571-mygj2nd4 1111 12 Motrin Motrin NNP cord-009571-mygj2nd4 1111 13 ( ( -LRB- cord-009571-mygj2nd4 1111 14 1600 1600 CD cord-009571-mygj2nd4 1111 15 me -PRON- PRP cord-009571-mygj2nd4 1111 16 ) ) -RRB- cord-009571-mygj2nd4 1111 17 , , , cord-009571-mygj2nd4 1111 18 Naprosyn Naprosyn NNP cord-009571-mygj2nd4 1111 19 ( ( -LRB- cord-009571-mygj2nd4 1111 20 500 500 CD cord-009571-mygj2nd4 1111 21 mg mg NNS cord-009571-mygj2nd4 1111 22 ) ) -RRB- cord-009571-mygj2nd4 1111 23 , , , cord-009571-mygj2nd4 1111 24 Motrin Motrin NNP cord-009571-mygj2nd4 1111 25 ( ( -LRB- cord-009571-mygj2nd4 1111 26 2400 2400 CD cord-009571-mygj2nd4 1111 27 mg mg NN cord-009571-mygj2nd4 1111 28 ) ) -RRB- cord-009571-mygj2nd4 1111 29 , , , cord-009571-mygj2nd4 1111 30 Indocin Indocin NNP cord-009571-mygj2nd4 1111 31 ( ( -LRB- cord-009571-mygj2nd4 1111 32 I50 I50 NNP cord-009571-mygj2nd4 1111 33 mg mg NNP cord-009571-mygj2nd4 1111 34 ) ) -RRB- cord-009571-mygj2nd4 1111 35 , , , cord-009571-mygj2nd4 1111 36 Indocin Indocin NNP cord-009571-mygj2nd4 1111 37 ( ( -LRB- cord-009571-mygj2nd4 1111 38 100 100 CD cord-009571-mygj2nd4 1111 39 mg mg NNS cord-009571-mygj2nd4 1111 40 ) ) -RRB- cord-009571-mygj2nd4 1111 41 , , , cord-009571-mygj2nd4 1111 42 Naprosyn Naprosyn NNP cord-009571-mygj2nd4 1111 43 ( ( -LRB- cord-009571-mygj2nd4 1111 44 750 750 CD cord-009571-mygj2nd4 1111 45 mg mg NNP cord-009571-mygj2nd4 1111 46 ) ) -RRB- cord-009571-mygj2nd4 1111 47 , , , cord-009571-mygj2nd4 1111 48 and and CC cord-009571-mygj2nd4 1111 49 aspirin aspirin NN cord-009571-mygj2nd4 1111 50 ( ( -LRB- cord-009571-mygj2nd4 1111 51 3.6 3.6 CD cord-009571-mygj2nd4 1111 52 gm gm NNP cord-009571-mygj2nd4 1111 53 ) ) -RRB- cord-009571-mygj2nd4 1111 54 . . . cord-009571-mygj2nd4 1112 1 In in IN cord-009571-mygj2nd4 1112 2 2 2 CD cord-009571-mygj2nd4 1112 3 patients patient NNS cord-009571-mygj2nd4 1112 4 receiving receive VBG cord-009571-mygj2nd4 1112 5 Naprosyn Naprosyn NNP cord-009571-mygj2nd4 1112 6 ( ( -LRB- cord-009571-mygj2nd4 1112 7 500 500 CD cord-009571-mygj2nd4 1112 8 mg mg NNP cord-009571-mygj2nd4 1112 9 ) ) -RRB- cord-009571-mygj2nd4 1112 10 and and CC cord-009571-mygj2nd4 1112 11 Indocin Indocin NNP cord-009571-mygj2nd4 1112 12 ( ( -LRB- cord-009571-mygj2nd4 1112 13 100 100 CD cord-009571-mygj2nd4 1112 14 mg mg NN cord-009571-mygj2nd4 1112 15 ) ) -RRB- cord-009571-mygj2nd4 1113 1 frank frank NNP cord-009571-mygj2nd4 1113 2 gastric gastric JJ cord-009571-mygj2nd4 1113 3 ulcer ulcer NN cord-009571-mygj2nd4 1113 4 was be VBD cord-009571-mygj2nd4 1113 5 produced produce VBN cord-009571-mygj2nd4 1113 6 . . . cord-009571-mygj2nd4 1114 1 Differences difference NNS cord-009571-mygj2nd4 1114 2 between between IN cord-009571-mygj2nd4 1114 3 Motrin Motrin NNP cord-009571-mygj2nd4 1114 4 1600 1600 CD cord-009571-mygj2nd4 1114 5 or or CC cord-009571-mygj2nd4 1114 6 2400 2400 CD cord-009571-mygj2nd4 1114 7 mg mg NN cord-009571-mygj2nd4 1114 8 and and CC cord-009571-mygj2nd4 1114 9 aspirin aspirin NN cord-009571-mygj2nd4 1114 10 were be VBD cord-009571-mygj2nd4 1114 11 highly highly RB cord-009571-mygj2nd4 1114 12 significant significant JJ cord-009571-mygj2nd4 1115 1 ( ( -LRB- cord-009571-mygj2nd4 1115 2 P p NN cord-009571-mygj2nd4 1115 3 < < XX cord-009571-mygj2nd4 1115 4 0.01 0.01 CD cord-009571-mygj2nd4 1115 5 ) ) -RRB- cord-009571-mygj2nd4 1116 1 as as IN cord-009571-mygj2nd4 1116 2 were be VBD cord-009571-mygj2nd4 1116 3 differences difference NNS cord-009571-mygj2nd4 1116 4 between between IN cord-009571-mygj2nd4 1116 5 aspirin aspirin NN cord-009571-mygj2nd4 1116 6 and and CC cord-009571-mygj2nd4 1116 7 placebo placebo NN cord-009571-mygj2nd4 1116 8 ( ( -LRB- cord-009571-mygj2nd4 1116 9 P p NN cord-009571-mygj2nd4 1116 10 < < XX cord-009571-mygj2nd4 1116 11 0,001 0,001 CD cord-009571-mygj2nd4 1116 12 ) ) -RRB- cord-009571-mygj2nd4 1116 13 . . . cord-009571-mygj2nd4 1117 1 Differences difference NNS cord-009571-mygj2nd4 1117 2 between between IN cord-009571-mygj2nd4 1117 3 Motrin Motrin NNP cord-009571-mygj2nd4 1117 4 ( ( -LRB- cord-009571-mygj2nd4 1117 5 1600 1600 CD cord-009571-mygj2nd4 1117 6 mg mg NNP cord-009571-mygj2nd4 1117 7 ) ) -RRB- cord-009571-mygj2nd4 1117 8 and and CC cord-009571-mygj2nd4 1117 9 Indocin Indocin NNP cord-009571-mygj2nd4 1117 10 ( ( -LRB- cord-009571-mygj2nd4 1117 11 100 100 CD cord-009571-mygj2nd4 1117 12 mg mg NNP cord-009571-mygj2nd4 1117 13 ) ) -RRB- cord-009571-mygj2nd4 1117 14 , , , cord-009571-mygj2nd4 1117 15 and and CC cord-009571-mygj2nd4 1117 16 between between IN cord-009571-mygj2nd4 1117 17 Motrin Motrin NNP cord-009571-mygj2nd4 1117 18 ( ( -LRB- cord-009571-mygj2nd4 1117 19 2400 2400 CD cord-009571-mygj2nd4 1117 20 mg mg NN cord-009571-mygj2nd4 1117 21 ) ) -RRB- cord-009571-mygj2nd4 1117 22 and and CC cord-009571-mygj2nd4 1117 23 Naprosyn Naprosyn NNP cord-009571-mygj2nd4 1117 24 ( ( -LRB- cord-009571-mygj2nd4 1117 25 750 750 CD cord-009571-mygj2nd4 1117 26 mg mg NN cord-009571-mygj2nd4 1117 27 ) ) -RRB- cord-009571-mygj2nd4 1117 28 approached approach VBD cord-009571-mygj2nd4 1117 29 significance significance NN cord-009571-mygj2nd4 1117 30 ( ( -LRB- cord-009571-mygj2nd4 1117 31 0.05 0.05 CD cord-009571-mygj2nd4 1117 32 < < XX cord-009571-mygj2nd4 1117 33 P p NN cord-009571-mygj2nd4 1117 34 < < XX cord-009571-mygj2nd4 1117 35 0.10 0.10 CD cord-009571-mygj2nd4 1117 36 ) ) -RRB- cord-009571-mygj2nd4 1117 37 . . . cord-009571-mygj2nd4 1118 1 Part part NN cord-009571-mygj2nd4 1118 2 11 11 CD cord-009571-mygj2nd4 1118 3 . . . cord-009571-mygj2nd4 1119 1 Of of IN cord-009571-mygj2nd4 1119 2 the the DT cord-009571-mygj2nd4 1119 3 5 5 CD cord-009571-mygj2nd4 1119 4 subjects subject NNS cord-009571-mygj2nd4 1119 5 taking take VBG cord-009571-mygj2nd4 1119 6 Tolectin Tolectin NNP cord-009571-mygj2nd4 1119 7 , , , cord-009571-mygj2nd4 1119 8 2 2 CD cord-009571-mygj2nd4 1119 9 had have VBD cord-009571-mygj2nd4 1119 10 hemorrhagic hemorrhagic JJ cord-009571-mygj2nd4 1119 11 gastritis gastritis NN cord-009571-mygj2nd4 1119 12 of of IN cord-009571-mygj2nd4 1119 13 a a DT cord-009571-mygj2nd4 1119 14 degree degree NN cord-009571-mygj2nd4 1119 15 comparable comparable JJ cord-009571-mygj2nd4 1119 16 to to IN cord-009571-mygj2nd4 1119 17 that that DT cord-009571-mygj2nd4 1119 18 with with IN cord-009571-mygj2nd4 1119 19 aspirin aspirin NN cord-009571-mygj2nd4 1119 20 , , , cord-009571-mygj2nd4 1119 21 and and CC cord-009571-mygj2nd4 1119 22 3 3 CD cord-009571-mygj2nd4 1119 23 had have VBD cord-009571-mygj2nd4 1119 24 similar similar JJ cord-009571-mygj2nd4 1119 25 but but CC cord-009571-mygj2nd4 1119 26 less less RBR cord-009571-mygj2nd4 1119 27 extensive extensive JJ cord-009571-mygj2nd4 1119 28 changes change NNS cord-009571-mygj2nd4 1119 29 . . . cord-009571-mygj2nd4 1120 1 One one CD cord-009571-mygj2nd4 1120 2 subject subject NN cord-009571-mygj2nd4 1120 3 on on IN cord-009571-mygj2nd4 1120 4 Motrin Motrin NNP cord-009571-mygj2nd4 1120 5 had have VBD cord-009571-mygj2nd4 1120 6 extensive extensive JJ cord-009571-mygj2nd4 1120 7 hemorrhagic hemorrhagic JJ cord-009571-mygj2nd4 1120 8 gastritis gastritis NN cord-009571-mygj2nd4 1120 9 as as IN cord-009571-mygj2nd4 1120 10 with with IN cord-009571-mygj2nd4 1120 11 aspirin aspirin NN cord-009571-mygj2nd4 1120 12 , , , cord-009571-mygj2nd4 1120 13 and and CC cord-009571-mygj2nd4 1120 14 4 4 CD cord-009571-mygj2nd4 1120 15 had have VBD cord-009571-mygj2nd4 1120 16 minimal minimal JJ cord-009571-mygj2nd4 1120 17 or or CC cord-009571-mygj2nd4 1120 18 no no DT cord-009571-mygj2nd4 1120 19 changes change NNS cord-009571-mygj2nd4 1120 20 . . . cord-009571-mygj2nd4 1121 1 In in IN cord-009571-mygj2nd4 1121 2 both both DT cord-009571-mygj2nd4 1121 3 parts part NNS cord-009571-mygj2nd4 1121 4 I -PRON- PRP cord-009571-mygj2nd4 1121 5 and and CC cord-009571-mygj2nd4 1121 6 11 11 CD cord-009571-mygj2nd4 1121 7 , , , cord-009571-mygj2nd4 1121 8 gastric gastric JJ cord-009571-mygj2nd4 1121 9 mucosal mucosal JJ cord-009571-mygj2nd4 1121 10 biopsies biopsy NNS cord-009571-mygj2nd4 1121 11 , , , cord-009571-mygj2nd4 1121 12 blood blood NN cord-009571-mygj2nd4 1121 13 levels level NNS cord-009571-mygj2nd4 1121 14 , , , cord-009571-mygj2nd4 1121 15 and and CC cord-009571-mygj2nd4 1121 16 photographs photograph NNS cord-009571-mygj2nd4 1121 17 confirmed confirm VBD cord-009571-mygj2nd4 1121 18 endoscopic endoscopic JJ cord-009571-mygj2nd4 1121 19 pathology pathology NN cord-009571-mygj2nd4 1121 20 . . . cord-009571-mygj2nd4 1122 1 This this DT cord-009571-mygj2nd4 1122 2 study study NN cord-009571-mygj2nd4 1122 3 demonstrated demonstrate VBD cord-009571-mygj2nd4 1122 4 that that IN cord-009571-mygj2nd4 1122 5 severe severe JJ cord-009571-mygj2nd4 1122 6 gastric gastric JJ cord-009571-mygj2nd4 1122 7 mucosal mucosal JJ cord-009571-mygj2nd4 1122 8 hemorrhagic hemorrhagic JJ cord-009571-mygj2nd4 1122 9 and and CC cord-009571-mygj2nd4 1122 10 ulcerative ulcerative JJ cord-009571-mygj2nd4 1122 11 changes change NNS cord-009571-mygj2nd4 1122 12 occur occur VBP cord-009571-mygj2nd4 1122 13 in in IN cord-009571-mygj2nd4 1122 14 subjects subject NNS cord-009571-mygj2nd4 1122 15 using use VBG cord-009571-mygj2nd4 1122 16 nonsteroidal nonsteroidal JJ cord-009571-mygj2nd4 1122 17 antiinflammatory antiinflammatory JJ cord-009571-mygj2nd4 1122 18 drugs drug NNS cord-009571-mygj2nd4 1122 19 , , , cord-009571-mygj2nd4 1122 20 and and CC cord-009571-mygj2nd4 1122 21 that that IN cord-009571-mygj2nd4 1122 22 significant significant JJ cord-009571-mygj2nd4 1122 23 differences difference NNS cord-009571-mygj2nd4 1122 24 exist exist VBP cord-009571-mygj2nd4 1122 25 between between IN cord-009571-mygj2nd4 1122 26 various various JJ cord-009571-mygj2nd4 1122 27 drugs drug NNS cord-009571-mygj2nd4 1122 28 . . . cord-009571-mygj2nd4 1123 1 Seven seven CD cord-009571-mygj2nd4 1123 2 patients patient NNS cord-009571-mygj2nd4 1123 3 with with IN cord-009571-mygj2nd4 1123 4 active active JJ cord-009571-mygj2nd4 1123 5 gonococcal gonococcal JJ cord-009571-mygj2nd4 1123 6 ( ( -LRB- cord-009571-mygj2nd4 1123 7 GC GC NNP cord-009571-mygj2nd4 1123 8 ) ) -RRB- cord-009571-mygj2nd4 1123 9 arthritis arthritis NNP cord-009571-mygj2nd4 1123 10 immunoelectrophoresis immunoelectrophoresis NNP cord-009571-mygj2nd4 1123 11 ( ( -LRB- cord-009571-mygj2nd4 1123 12 CIE CIE NNP cord-009571-mygj2nd4 1123 13 ) ) -RRB- cord-009571-mygj2nd4 1123 14 . . . cord-009571-mygj2nd4 1124 1 The the DT cord-009571-mygj2nd4 1124 2 diagnosis diagnosis NN cord-009571-mygj2nd4 1124 3 of of IN cord-009571-mygj2nd4 1124 4 GC GC NNP cord-009571-mygj2nd4 1124 5 arthritis arthritis NN cord-009571-mygj2nd4 1124 6 were be VBD cord-009571-mygj2nd4 1124 7 studied study VBN cord-009571-mygj2nd4 1124 8 for for IN cord-009571-mygj2nd4 1124 9 the the DT cord-009571-mygj2nd4 1124 10 presence presence NN cord-009571-mygj2nd4 1124 11 of of IN cord-009571-mygj2nd4 1124 12 GC GC NNP cord-009571-mygj2nd4 1124 13 antigen antigen NNP cord-009571-mygj2nd4 1124 14 ( ( -LRB- cord-009571-mygj2nd4 1124 15 AG AG NNP cord-009571-mygj2nd4 1124 16 ) ) -RRB- cord-009571-mygj2nd4 1124 17 and and CC cord-009571-mygj2nd4 1124 18 anti anti JJ cord-009571-mygj2nd4 1124 19 - - NN cord-009571-mygj2nd4 1124 20 in in IN cord-009571-mygj2nd4 1124 21 all all DT cord-009571-mygj2nd4 1124 22 seven seven CD cord-009571-mygj2nd4 1124 23 patients patient NNS cord-009571-mygj2nd4 1124 24 was be VBD cord-009571-mygj2nd4 1124 25 made make VBN cord-009571-mygj2nd4 1124 26 by by IN cord-009571-mygj2nd4 1124 27 typical typical JJ cord-009571-mygj2nd4 1124 28 clinical clinical JJ cord-009571-mygj2nd4 1124 29 presentation presentation NN cord-009571-mygj2nd4 1124 30 , , , cord-009571-mygj2nd4 1124 31 body body NN cord-009571-mygj2nd4 1124 32 ( ( -LRB- cord-009571-mygj2nd4 1124 33 AB AB NNP cord-009571-mygj2nd4 1124 34 ) ) -RRB- cord-009571-mygj2nd4 1124 35 in in IN cord-009571-mygj2nd4 1124 36 serum serum NN cord-009571-mygj2nd4 1124 37 and and CC cord-009571-mygj2nd4 1124 38 synovial synovial JJ cord-009571-mygj2nd4 1124 39 fluid fluid NN cord-009571-mygj2nd4 1124 40 by by IN cord-009571-mygj2nd4 1124 41 counter counter JJ cord-009571-mygj2nd4 1124 42 - - JJ cord-009571-mygj2nd4 1124 43 positive positive JJ cord-009571-mygj2nd4 1124 44 local local JJ cord-009571-mygj2nd4 1124 45 culture culture NN cord-009571-mygj2nd4 1124 46 for for IN cord-009571-mygj2nd4 1124 47 Ngonorrhoeae Ngonorrhoeae NNP cord-009571-mygj2nd4 1124 48 ( ( -LRB- cord-009571-mygj2nd4 1124 49 NG NG NNP cord-009571-mygj2nd4 1124 50 ) ) -RRB- cord-009571-mygj2nd4 1124 51 , , , cord-009571-mygj2nd4 1124 52 and and CC cord-009571-mygj2nd4 1124 53 response response NN cord-009571-mygj2nd4 1124 54 to to IN cord-009571-mygj2nd4 1124 55 treatment treatment NN cord-009571-mygj2nd4 1124 56 . . . cord-009571-mygj2nd4 1125 1 Gram gram NN cord-009571-mygj2nd4 1125 2 stain stain NN cord-009571-mygj2nd4 1125 3 and and CC cord-009571-mygj2nd4 1125 4 culture culture NN cord-009571-mygj2nd4 1125 5 of of IN cord-009571-mygj2nd4 1125 6 synovial synovial JJ cord-009571-mygj2nd4 1125 7 fluid fluid NN cord-009571-mygj2nd4 1125 8 , , , cord-009571-mygj2nd4 1125 9 as as RB cord-009571-mygj2nd4 1125 10 well well RB cord-009571-mygj2nd4 1125 11 as as IN cord-009571-mygj2nd4 1125 12 blood blood NN cord-009571-mygj2nd4 1125 13 cultures culture NNS cord-009571-mygj2nd4 1125 14 , , , cord-009571-mygj2nd4 1125 15 were be VBD cord-009571-mygj2nd4 1125 16 negative negative JJ cord-009571-mygj2nd4 1125 17 in in IN cord-009571-mygj2nd4 1125 18 all all DT cord-009571-mygj2nd4 1125 19 patients patient NNS cord-009571-mygj2nd4 1125 20 . . . cord-009571-mygj2nd4 1126 1 Specimens specimen NNS cord-009571-mygj2nd4 1126 2 were be VBD cord-009571-mygj2nd4 1126 3 run run VBN cord-009571-mygj2nd4 1126 4 against against IN cord-009571-mygj2nd4 1126 5 rabbit rabbit NN cord-009571-mygj2nd4 1126 6 antisera antisera NN cord-009571-mygj2nd4 1126 7 to to IN cord-009571-mygj2nd4 1126 8 N n NN cord-009571-mygj2nd4 1126 9 G G NNP cord-009571-mygj2nd4 1126 10 ( ( -LRB- cord-009571-mygj2nd4 1126 11 Difco Difco NNP cord-009571-mygj2nd4 1126 12 ) ) -RRB- cord-009571-mygj2nd4 1126 13 to to TO cord-009571-mygj2nd4 1126 14 detect detect VB cord-009571-mygj2nd4 1126 15 GC GC NNP cord-009571-mygj2nd4 1126 16 A a DT cord-009571-mygj2nd4 1126 17 G g NN cord-009571-mygj2nd4 1126 18 and and CC cord-009571-mygj2nd4 1126 19 against against IN cord-009571-mygj2nd4 1126 20 a a DT cord-009571-mygj2nd4 1126 21 turbid turbid JJ cord-009571-mygj2nd4 1126 22 solution solution NN cord-009571-mygj2nd4 1126 23 of of IN cord-009571-mygj2nd4 1126 24 fresh fresh JJ cord-009571-mygj2nd4 1126 25 isolates isolate NNS cord-009571-mygj2nd4 1126 26 of of IN cord-009571-mygj2nd4 1126 27 N n CD cord-009571-mygj2nd4 1126 28 G g NN cord-009571-mygj2nd4 1126 29 to to TO cord-009571-mygj2nd4 1126 30 detect detect VB cord-009571-mygj2nd4 1126 31 G g NN cord-009571-mygj2nd4 1126 32 C c NN cord-009571-mygj2nd4 1126 33 AB ab NN cord-009571-mygj2nd4 1126 34 . . . cord-009571-mygj2nd4 1127 1 Glass glass NN cord-009571-mygj2nd4 1127 2 slides slide NNS cord-009571-mygj2nd4 1127 3 were be VBD cord-009571-mygj2nd4 1127 4 coated coat VBN cord-009571-mygj2nd4 1127 5 with with IN cord-009571-mygj2nd4 1127 6 3 3 CD cord-009571-mygj2nd4 1127 7 ml ml NNS cord-009571-mygj2nd4 1127 8 of of IN cord-009571-mygj2nd4 1127 9 0.015 0.015 CD cord-009571-mygj2nd4 1127 10 M M NNP cord-009571-mygj2nd4 1127 11 agarose agarose VBD cord-009571-mygj2nd4 1127 12 in in IN cord-009571-mygj2nd4 1127 13 0.075 0.075 CD cord-009571-mygj2nd4 1127 14 M M NNP cord-009571-mygj2nd4 1127 15 barbital barbital JJ cord-009571-mygj2nd4 1127 16 buffer buffer NN cord-009571-mygj2nd4 1127 17 p p NN cord-009571-mygj2nd4 1127 18 H H NNP cord-009571-mygj2nd4 1127 19 8.6 8.6 CD cord-009571-mygj2nd4 1127 20 . . . cord-009571-mygj2nd4 1128 1 Pairs pair NNS cord-009571-mygj2nd4 1128 2 of of IN cord-009571-mygj2nd4 1128 3 wells well NNS cord-009571-mygj2nd4 1128 4 3 3 CD cord-009571-mygj2nd4 1128 5 mm mm NNP cord-009571-mygj2nd4 1128 6 apart apart RB cord-009571-mygj2nd4 1128 7 and and CC cord-009571-mygj2nd4 1128 8 3 3 CD cord-009571-mygj2nd4 1128 9 mm mm NN cord-009571-mygj2nd4 1128 10 in in IN cord-009571-mygj2nd4 1128 11 diameter diameter NN cord-009571-mygj2nd4 1128 12 were be VBD cord-009571-mygj2nd4 1128 13 cut cut VBN cord-009571-mygj2nd4 1128 14 in in IN cord-009571-mygj2nd4 1128 15 the the DT cord-009571-mygj2nd4 1128 16 agar agar NN cord-009571-mygj2nd4 1128 17 and and CC cord-009571-mygj2nd4 1128 18 filled fill VBN cord-009571-mygj2nd4 1128 19 with with IN cord-009571-mygj2nd4 1128 20 lop1 lop1 DT cord-009571-mygj2nd4 1128 21 of of IN cord-009571-mygj2nd4 1128 22 samples sample NNS cord-009571-mygj2nd4 1128 23 - - : cord-009571-mygj2nd4 1128 24 AG AG NNP cord-009571-mygj2nd4 1128 25 in in IN cord-009571-mygj2nd4 1128 26 the the DT cord-009571-mygj2nd4 1128 27 cathode cathode NN cord-009571-mygj2nd4 1128 28 well well RB cord-009571-mygj2nd4 1128 29 and and CC cord-009571-mygj2nd4 1128 30 AB ab NN cord-009571-mygj2nd4 1128 31 in in IN cord-009571-mygj2nd4 1128 32 the the DT cord-009571-mygj2nd4 1128 33 anode anode NN cord-009571-mygj2nd4 1128 34 well well RB cord-009571-mygj2nd4 1128 35 . . . cord-009571-mygj2nd4 1129 1 Slides slide NNS cord-009571-mygj2nd4 1129 2 were be VBD cord-009571-mygj2nd4 1129 3 electrophoresed electrophorese VBN cord-009571-mygj2nd4 1129 4 in in IN cord-009571-mygj2nd4 1129 5 barbital barbital JJ cord-009571-mygj2nd4 1129 6 buffer buffer NN cord-009571-mygj2nd4 1129 7 for for IN cord-009571-mygj2nd4 1129 8 45 45 CD cord-009571-mygj2nd4 1129 9 minutes minute NNS cord-009571-mygj2nd4 1129 10 at at IN cord-009571-mygj2nd4 1129 11 room room NN cord-009571-mygj2nd4 1129 12 temperature temperature NN cord-009571-mygj2nd4 1129 13 at at IN cord-009571-mygj2nd4 1129 14 4 4 CD cord-009571-mygj2nd4 1129 15 mamps mamps NNP cord-009571-mygj2nd4 1129 16 / / SYM cord-009571-mygj2nd4 1129 17 slide slide NN cord-009571-mygj2nd4 1129 18 , , , cord-009571-mygj2nd4 1129 19 and and CC cord-009571-mygj2nd4 1129 20 examined examine VBD cord-009571-mygj2nd4 1129 21 for for IN cord-009571-mygj2nd4 1129 22 the the DT cord-009571-mygj2nd4 1129 23 presence presence NN cord-009571-mygj2nd4 1129 24 of of IN cord-009571-mygj2nd4 1129 25 precipitin precipitin NNP cord-009571-mygj2nd4 1129 26 lines line NNS cord-009571-mygj2nd4 1129 27 . . . cord-009571-mygj2nd4 1130 1 Results result NNS cord-009571-mygj2nd4 1130 2 are be VBP cord-009571-mygj2nd4 1130 3 shown show VBN cord-009571-mygj2nd4 1130 4 in in IN cord-009571-mygj2nd4 1130 5 the the DT cord-009571-mygj2nd4 1130 6 table table NN cord-009571-mygj2nd4 1130 7 . . . cord-009571-mygj2nd4 1131 1 G g NN cord-009571-mygj2nd4 1131 2 C c NN cord-009571-mygj2nd4 1131 3 A a NN cord-009571-mygj2nd4 1131 4 G g NN cord-009571-mygj2nd4 1131 5 was be VBD cord-009571-mygj2nd4 1131 6 found find VBN cord-009571-mygj2nd4 1131 7 in in IN cord-009571-mygj2nd4 1131 8 the the DT cord-009571-mygj2nd4 1131 9 serum serum NN cord-009571-mygj2nd4 1131 10 of of IN cord-009571-mygj2nd4 1131 11 1 1 CD cord-009571-mygj2nd4 1131 12 patient patient NN cord-009571-mygj2nd4 1131 13 and and CC cord-009571-mygj2nd4 1131 14 in in IN cord-009571-mygj2nd4 1131 15 the the DT cord-009571-mygj2nd4 1131 16 synovial synovial JJ cord-009571-mygj2nd4 1131 17 fluid fluid NN cord-009571-mygj2nd4 1131 18 of of IN cord-009571-mygj2nd4 1131 19 3 3 CD cord-009571-mygj2nd4 1131 20 others other NNS cord-009571-mygj2nd4 1131 21 . . . cord-009571-mygj2nd4 1132 1 GC GC NNP cord-009571-mygj2nd4 1132 2 AB AB NNP cord-009571-mygj2nd4 1132 3 was be VBD cord-009571-mygj2nd4 1132 4 detected detect VBN cord-009571-mygj2nd4 1132 5 in in IN cord-009571-mygj2nd4 1132 6 the the DT cord-009571-mygj2nd4 1132 7 serum serum NN cord-009571-mygj2nd4 1132 8 of of IN cord-009571-mygj2nd4 1132 9 the the DT cord-009571-mygj2nd4 1132 10 remaining remain VBG cord-009571-mygj2nd4 1132 11 3 3 CD cord-009571-mygj2nd4 1132 12 patients patient NNS cord-009571-mygj2nd4 1132 13 and and CC cord-009571-mygj2nd4 1132 14 in in IN cord-009571-mygj2nd4 1132 15 simultaneous simultaneous JJ cord-009571-mygj2nd4 1132 16 synovial synovial JJ cord-009571-mygj2nd4 1132 17 fluid fluid NN cord-009571-mygj2nd4 1132 18 of of IN cord-009571-mygj2nd4 1132 19 2 2 CD cord-009571-mygj2nd4 1132 20 of of IN cord-009571-mygj2nd4 1132 21 these these DT cord-009571-mygj2nd4 1132 22 . . . cord-009571-mygj2nd4 1133 1 G g NN cord-009571-mygj2nd4 1133 2 C c NN cord-009571-mygj2nd4 1133 3 AB AB NNP cord-009571-mygj2nd4 1133 4 was be VBD cord-009571-mygj2nd4 1133 5 absent absent JJ cord-009571-mygj2nd4 1133 6 in in IN cord-009571-mygj2nd4 1133 7 convalescent convalescent JJ cord-009571-mygj2nd4 1133 8 serum serum NN cord-009571-mygj2nd4 1133 9 in in IN cord-009571-mygj2nd4 1133 10 patients patient NNS cord-009571-mygj2nd4 1133 11 # # $ cord-009571-mygj2nd4 1133 12 6 6 CD cord-009571-mygj2nd4 1133 13 and and CC cord-009571-mygj2nd4 1133 14 # # $ cord-009571-mygj2nd4 1133 15 7 7 CD cord-009571-mygj2nd4 1133 16 at at IN cord-009571-mygj2nd4 1133 17 2 2 CD cord-009571-mygj2nd4 1133 18 months month NNS cord-009571-mygj2nd4 1133 19 . . . cord-009571-mygj2nd4 1134 1 Only only RB cord-009571-mygj2nd4 1134 2 l l NN cord-009571-mygj2nd4 1134 3 of of IN cord-009571-mygj2nd4 1134 4 30 30 CD cord-009571-mygj2nd4 1134 5 patients patient NNS cord-009571-mygj2nd4 1134 6 with with IN cord-009571-mygj2nd4 1134 7 initial initial JJ cord-009571-mygj2nd4 1134 8 or or CC cord-009571-mygj2nd4 1134 9 recurrent recurrent JJ cord-009571-mygj2nd4 1134 10 active active JJ cord-009571-mygj2nd4 1134 11 GC GC NNP cord-009571-mygj2nd4 1134 12 urethritis urethritis NN cord-009571-mygj2nd4 1134 13 , , , cord-009571-mygj2nd4 1134 14 cervicitis cervicitis NN cord-009571-mygj2nd4 1134 15 , , , cord-009571-mygj2nd4 1134 16 or or CC cord-009571-mygj2nd4 1134 17 salpingitis salpingitis NNP cord-009571-mygj2nd4 1134 18 had have VBD cord-009571-mygj2nd4 1134 19 serum serum NN cord-009571-mygj2nd4 1134 20 G g NN cord-009571-mygj2nd4 1134 21 C c NN cord-009571-mygj2nd4 1134 22 AB ab NN cord-009571-mygj2nd4 1134 23 detected detect VBN cord-009571-mygj2nd4 1134 24 by by IN cord-009571-mygj2nd4 1134 25 CIE CIE NNP cord-009571-mygj2nd4 1134 26 ; ; : cord-009571-mygj2nd4 1134 27 none none NN cord-009571-mygj2nd4 1134 28 had have VBD cord-009571-mygj2nd4 1134 29 G g NN cord-009571-mygj2nd4 1134 30 C c NN cord-009571-mygj2nd4 1134 31 AG AG NNP cord-009571-mygj2nd4 1134 32 . . . cord-009571-mygj2nd4 1135 1 These these DT cord-009571-mygj2nd4 1135 2 Synovial Synovial NNP cord-009571-mygj2nd4 1135 3 Fluid Fluid NNP cord-009571-mygj2nd4 1135 4 Patient Patient NNP cord-009571-mygj2nd4 1136 1 No no UH cord-009571-mygj2nd4 1136 2 . . . cord-009571-mygj2nd4 1137 1 results result NNS cord-009571-mygj2nd4 1137 2 suggest suggest VBP cord-009571-mygj2nd4 1137 3 that that IN cord-009571-mygj2nd4 1137 4 the the DT cord-009571-mygj2nd4 1137 5 finding finding NN cord-009571-mygj2nd4 1137 6 of of IN cord-009571-mygj2nd4 1137 7 GC GC NNP cord-009571-mygj2nd4 1137 8 A a DT cord-009571-mygj2nd4 1137 9 G g NN cord-009571-mygj2nd4 1137 10 or or CC cord-009571-mygj2nd4 1137 11 AB ab NN cord-009571-mygj2nd4 1137 12 in in IN cord-009571-mygj2nd4 1137 13 synovial synovial JJ cord-009571-mygj2nd4 1137 14 fluid fluid NN cord-009571-mygj2nd4 1137 15 o o NN cord-009571-mygj2nd4 1137 16 r r NN cord-009571-mygj2nd4 1137 17 serum serum NN cord-009571-mygj2nd4 1137 18 by by IN cord-009571-mygj2nd4 1137 19 CIE CIE NNP cord-009571-mygj2nd4 1137 20 provides provide VBZ cord-009571-mygj2nd4 1137 21 evidence evidence NN cord-009571-mygj2nd4 1137 22 for for IN cord-009571-mygj2nd4 1137 23 GC GC NNP cord-009571-mygj2nd4 1137 24 arthritis arthritis NN cord-009571-mygj2nd4 1137 25 and and CC cord-009571-mygj2nd4 1137 26 may may MD cord-009571-mygj2nd4 1137 27 be be VB cord-009571-mygj2nd4 1137 28 positive positive JJ cord-009571-mygj2nd4 1137 29 when when WRB cord-009571-mygj2nd4 1137 30 gram gram NN cord-009571-mygj2nd4 1137 31 stain stain NN cord-009571-mygj2nd4 1137 32 and and CC cord-009571-mygj2nd4 1137 33 culture culture NN cord-009571-mygj2nd4 1137 34 are be VBP cord-009571-mygj2nd4 1137 35 negative negative JJ cord-009571-mygj2nd4 1137 36 . . . cord-009571-mygj2nd4 1138 1 CIE CIE NNP cord-009571-mygj2nd4 1138 2 therefore therefore RB cord-009571-mygj2nd4 1138 3 appears appear VBZ cord-009571-mygj2nd4 1138 4 to to TO cord-009571-mygj2nd4 1138 5 be be VB cord-009571-mygj2nd4 1138 6 a a DT cord-009571-mygj2nd4 1138 7 useful useful JJ cord-009571-mygj2nd4 1138 8 test test NN cord-009571-mygj2nd4 1138 9 in in IN cord-009571-mygj2nd4 1138 10 the the DT cord-009571-mygj2nd4 1138 11 diagnosis diagnosis NN cord-009571-mygj2nd4 1138 12 of of IN cord-009571-mygj2nd4 1138 13 this this DT cord-009571-mygj2nd4 1138 14 condition condition NN cord-009571-mygj2nd4 1138 15 . . . cord-009571-mygj2nd4 1139 1 F F NNP cord-009571-mygj2nd4 1139 2 M M NNP cord-009571-mygj2nd4 1139 3 F F NNP cord-009571-mygj2nd4 1139 4 frequently frequently RB cord-009571-mygj2nd4 1139 5 presents present VBZ cord-009571-mygj2nd4 1139 6 a a DT cord-009571-mygj2nd4 1139 7 diagnostic diagnostic JJ cord-009571-mygj2nd4 1139 8 dilemma dilemma NN cord-009571-mygj2nd4 1139 9 in in IN cord-009571-mygj2nd4 1139 10 childhood childhood NN cord-009571-mygj2nd4 1139 11 . . . cord-009571-mygj2nd4 1140 1 Its -PRON- PRP$ cord-009571-mygj2nd4 1140 2 musculoskeletal musculoskeletal JJ cord-009571-mygj2nd4 1140 3 manifestations manifestation NNS cord-009571-mygj2nd4 1140 4 may may MD cord-009571-mygj2nd4 1140 5 be be VB cord-009571-mygj2nd4 1140 6 confused confuse VBN cord-009571-mygj2nd4 1140 7 with with IN cord-009571-mygj2nd4 1140 8 septic septic JJ cord-009571-mygj2nd4 1140 9 arthritis arthritis NN cord-009571-mygj2nd4 1140 10 , , , cord-009571-mygj2nd4 1140 11 juvenile juvenile JJ cord-009571-mygj2nd4 1140 12 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1140 13 arthritis arthritis NN cord-009571-mygj2nd4 1140 14 , , , cord-009571-mygj2nd4 1140 15 ankylosing ankylosing NN cord-009571-mygj2nd4 1140 16 spondylitis spondylitis NN cord-009571-mygj2nd4 1140 17 , , , cord-009571-mygj2nd4 1140 18 or or CC cord-009571-mygj2nd4 1140 19 other other JJ cord-009571-mygj2nd4 1140 20 rheumatic rheumatic JJ cord-009571-mygj2nd4 1140 21 disease disease NN cord-009571-mygj2nd4 1140 22 . . . cord-009571-mygj2nd4 1141 1 Although although IN cord-009571-mygj2nd4 1141 2 80 80 CD cord-009571-mygj2nd4 1141 3 % % NN cord-009571-mygj2nd4 1141 4 of of IN cord-009571-mygj2nd4 1141 5 patients patient NNS cord-009571-mygj2nd4 1141 6 have have VBP cord-009571-mygj2nd4 1141 7 symptom symptom NN cord-009571-mygj2nd4 1141 8 onset onset NN cord-009571-mygj2nd4 1141 9 in in IN cord-009571-mygj2nd4 1141 10 childhood childhood NN cord-009571-mygj2nd4 1141 11 , , , cord-009571-mygj2nd4 1141 12 diagnosis diagnosis NN cord-009571-mygj2nd4 1141 13 is be VBZ cord-009571-mygj2nd4 1141 14 usually usually RB cord-009571-mygj2nd4 1141 15 delayed delay VBN cord-009571-mygj2nd4 1141 16 . . . cord-009571-mygj2nd4 1142 1 We -PRON- PRP cord-009571-mygj2nd4 1142 2 have have VBP cord-009571-mygj2nd4 1142 3 followed follow VBN cord-009571-mygj2nd4 1142 4 31 31 CD cord-009571-mygj2nd4 1142 5 patients patient NNS cord-009571-mygj2nd4 1142 6 who who WP cord-009571-mygj2nd4 1142 7 presented present VBD cord-009571-mygj2nd4 1142 8 before before IN cord-009571-mygj2nd4 1142 9 age age NN cord-009571-mygj2nd4 1142 10 19 19 CD cord-009571-mygj2nd4 1142 11 years year NNS cord-009571-mygj2nd4 1142 12 . . . cord-009571-mygj2nd4 1143 1 There there EX cord-009571-mygj2nd4 1143 2 were be VBD cord-009571-mygj2nd4 1143 3 16 16 CD cord-009571-mygj2nd4 1143 4 male male NN cord-009571-mygj2nd4 1143 5 and and CC cord-009571-mygj2nd4 1143 6 15 15 CD cord-009571-mygj2nd4 1143 7 female female JJ cord-009571-mygj2nd4 1143 8 children child NNS cord-009571-mygj2nd4 1143 9 . . . cord-009571-mygj2nd4 1144 1 The the DT cord-009571-mygj2nd4 1144 2 mean mean JJ cord-009571-mygj2nd4 1144 3 age age NN cord-009571-mygj2nd4 1144 4 of of IN cord-009571-mygj2nd4 1144 5 onset onset NN cord-009571-mygj2nd4 1144 6 was be VBD cord-009571-mygj2nd4 1144 7 4.4 4.4 CD cord-009571-mygj2nd4 1144 8 years year NNS cord-009571-mygj2nd4 1145 1 ( ( -LRB- cord-009571-mygj2nd4 1145 2 range range NNP cord-009571-mygj2nd4 1145 3 1 1 CD cord-009571-mygj2nd4 1145 4 - - SYM cord-009571-mygj2nd4 1145 5 14 14 CD cord-009571-mygj2nd4 1145 6 ) ) -RRB- cord-009571-mygj2nd4 1145 7 ; ; : cord-009571-mygj2nd4 1145 8 mean mean VB cord-009571-mygj2nd4 1145 9 age age NN cord-009571-mygj2nd4 1145 10 at at IN cord-009571-mygj2nd4 1145 11 diagnosis diagnosis NN cord-009571-mygj2nd4 1145 12 was be VBD cord-009571-mygj2nd4 1145 13 9.3 9.3 CD cord-009571-mygj2nd4 1145 14 years year NNS cord-009571-mygj2nd4 1146 1 ( ( -LRB- cord-009571-mygj2nd4 1146 2 range range NNP cord-009571-mygj2nd4 1146 3 2 2 CD cord-009571-mygj2nd4 1146 4 - - SYM cord-009571-mygj2nd4 1146 5 18 18 CD cord-009571-mygj2nd4 1146 6 ) ) -RRB- cord-009571-mygj2nd4 1146 7 . . . cord-009571-mygj2nd4 1147 1 There there EX cord-009571-mygj2nd4 1147 2 were be VBD cord-009571-mygj2nd4 1147 3 23 23 CD cord-009571-mygj2nd4 1147 4 Armenians Armenians NNPS cord-009571-mygj2nd4 1147 5 , , , cord-009571-mygj2nd4 1147 6 3 3 CD cord-009571-mygj2nd4 1147 7 Sephardic sephardic JJ cord-009571-mygj2nd4 1147 8 Jews Jews NNPS cord-009571-mygj2nd4 1147 9 , , , cord-009571-mygj2nd4 1147 10 and and CC cord-009571-mygj2nd4 1147 11 5 5 CD cord-009571-mygj2nd4 1147 12 of of IN cord-009571-mygj2nd4 1147 13 other other JJ cord-009571-mygj2nd4 1147 14 ethnic ethnic JJ cord-009571-mygj2nd4 1147 15 origins origin NNS cord-009571-mygj2nd4 1147 16 . . . cord-009571-mygj2nd4 1148 1 All all DT cord-009571-mygj2nd4 1148 2 had have VBD cord-009571-mygj2nd4 1148 3 recurrent recurrent JJ cord-009571-mygj2nd4 1148 4 fever fever NN cord-009571-mygj2nd4 1148 5 and and CC cord-009571-mygj2nd4 1148 6 peritonitis peritonitis NN cord-009571-mygj2nd4 1148 7 , , , cord-009571-mygj2nd4 1148 8 pleuritis pleuritis NNP cord-009571-mygj2nd4 1148 9 , , , cord-009571-mygj2nd4 1148 10 or or CC cord-009571-mygj2nd4 1148 11 arthritis arthritis NN cord-009571-mygj2nd4 1148 12 , , , cord-009571-mygj2nd4 1148 13 without without IN cord-009571-mygj2nd4 1148 14 evidence evidence NN cord-009571-mygj2nd4 1148 15 of of IN cord-009571-mygj2nd4 1148 16 other other JJ cord-009571-mygj2nd4 1148 17 rheumatic rheumatic JJ cord-009571-mygj2nd4 1148 18 or or CC cord-009571-mygj2nd4 1148 19 nonrheumatic nonrheumatic JJ cord-009571-mygj2nd4 1148 20 disease disease NN cord-009571-mygj2nd4 1148 21 . . . cord-009571-mygj2nd4 1149 1 All all DT cord-009571-mygj2nd4 1149 2 were be VBD cord-009571-mygj2nd4 1149 3 of of IN cord-009571-mygj2nd4 1149 4 Mediterranean mediterranean JJ cord-009571-mygj2nd4 1149 5 ancestry ancestry NN cord-009571-mygj2nd4 1149 6 . . . cord-009571-mygj2nd4 1150 1 Presenting present VBG cord-009571-mygj2nd4 1150 2 complaints complaint NNS cord-009571-mygj2nd4 1150 3 included include VBD cord-009571-mygj2nd4 1150 4 fever fever NN cord-009571-mygj2nd4 1150 5 in in IN cord-009571-mygj2nd4 1150 6 loo% loo% NNP cord-009571-mygj2nd4 1150 7 , , , cord-009571-mygj2nd4 1150 8 abdominal abdominal JJ cord-009571-mygj2nd4 1150 9 pain pain NN cord-009571-mygj2nd4 1150 10 in in IN cord-009571-mygj2nd4 1150 11 90 90 CD cord-009571-mygj2nd4 1150 12 % % NN cord-009571-mygj2nd4 1150 13 , , , cord-009571-mygj2nd4 1150 14 chest chest NN cord-009571-mygj2nd4 1150 15 pain pain NN cord-009571-mygj2nd4 1150 16 in in IN cord-009571-mygj2nd4 1150 17 62%,joint 62%,joint CD cord-009571-mygj2nd4 1150 18 pain pain NN cord-009571-mygj2nd4 1150 19 in in IN cord-009571-mygj2nd4 1150 20 45 45 CD cord-009571-mygj2nd4 1150 21 % % NN cord-009571-mygj2nd4 1150 22 , , , cord-009571-mygj2nd4 1150 23 and and CC cord-009571-mygj2nd4 1150 24 skin skin NN cord-009571-mygj2nd4 1150 25 rash rash NN cord-009571-mygj2nd4 1150 26 in in IN cord-009571-mygj2nd4 1150 27 7 7 CD cord-009571-mygj2nd4 1150 28 % % NN cord-009571-mygj2nd4 1150 29 . . . cord-009571-mygj2nd4 1151 1 Musculoskeletal musculoskeletal JJ cord-009571-mygj2nd4 1151 2 manifestations manifestation NNS cord-009571-mygj2nd4 1151 3 ranged range VBD cord-009571-mygj2nd4 1151 4 from from IN cord-009571-mygj2nd4 1151 5 arthralgias arthralgias NNP cord-009571-mygj2nd4 1151 6 to to IN cord-009571-mygj2nd4 1151 7 arthritis arthritis NN cord-009571-mygj2nd4 1151 8 . . . cord-009571-mygj2nd4 1152 1 The the DT cord-009571-mygj2nd4 1152 2 knees knee NNS cord-009571-mygj2nd4 1152 3 were be VBD cord-009571-mygj2nd4 1152 4 involved involve VBN cord-009571-mygj2nd4 1152 5 in in IN cord-009571-mygj2nd4 1152 6 8 8 CD cord-009571-mygj2nd4 1152 7 children child NNS cord-009571-mygj2nd4 1152 8 , , , cord-009571-mygj2nd4 1152 9 ankles ankle NNS cord-009571-mygj2nd4 1152 10 in in IN cord-009571-mygj2nd4 1152 11 6 6 CD cord-009571-mygj2nd4 1152 12 , , , cord-009571-mygj2nd4 1152 13 shoulders shoulder NNS cord-009571-mygj2nd4 1152 14 in in IN cord-009571-mygj2nd4 1152 15 2 2 CD cord-009571-mygj2nd4 1152 16 , , , cord-009571-mygj2nd4 1152 17 sacroiliac sacroiliac NN cord-009571-mygj2nd4 1152 18 joint joint NN cord-009571-mygj2nd4 1152 19 in in IN cord-009571-mygj2nd4 1152 20 2 2 CD cord-009571-mygj2nd4 1152 21 , , , cord-009571-mygj2nd4 1152 22 and and CC cord-009571-mygj2nd4 1152 23 wrists wrist NNS cord-009571-mygj2nd4 1152 24 in in IN cord-009571-mygj2nd4 1152 25 1 1 CD cord-009571-mygj2nd4 1152 26 . . . cord-009571-mygj2nd4 1153 1 Both both DT cord-009571-mygj2nd4 1153 2 children child NNS cord-009571-mygj2nd4 1153 3 with with IN cord-009571-mygj2nd4 1153 4 sacroiliac sacroiliac NN cord-009571-mygj2nd4 1153 5 joint joint JJ cord-009571-mygj2nd4 1153 6 involvement involvement NN cord-009571-mygj2nd4 1153 7 had have VBD cord-009571-mygj2nd4 1153 8 marked mark VBN cord-009571-mygj2nd4 1153 9 erosive erosive JJ cord-009571-mygj2nd4 1153 10 changes change NNS cord-009571-mygj2nd4 1153 11 and and CC cord-009571-mygj2nd4 1153 12 were be VBD cord-009571-mygj2nd4 1153 13 initially initially RB cord-009571-mygj2nd4 1153 14 thought think VBN cord-009571-mygj2nd4 1153 15 to to TO cord-009571-mygj2nd4 1153 16 have have VB cord-009571-mygj2nd4 1153 17 ankylosing ankylosing NN cord-009571-mygj2nd4 1153 18 spondylitis spondylitis NN cord-009571-mygj2nd4 1153 19 . . . cord-009571-mygj2nd4 1154 1 Four four CD cord-009571-mygj2nd4 1154 2 patients patient NNS cord-009571-mygj2nd4 1154 3 had have VBD cord-009571-mygj2nd4 1154 4 splenomegaly splenomegaly NN cord-009571-mygj2nd4 1154 5 . . . cord-009571-mygj2nd4 1155 1 N n NN cord-009571-mygj2nd4 1155 2 o o NN cord-009571-mygj2nd4 1155 3 patient patient NN cord-009571-mygj2nd4 1155 4 had have VBD cord-009571-mygj2nd4 1155 5 proteinuria proteinuria VBN cord-009571-mygj2nd4 1156 1 o o UH cord-009571-mygj2nd4 1156 2 r r NN cord-009571-mygj2nd4 1156 3 other other JJ cord-009571-mygj2nd4 1156 4 evidence evidence NN cord-009571-mygj2nd4 1156 5 of of IN cord-009571-mygj2nd4 1156 6 amyloidosis amyloidosis NN cord-009571-mygj2nd4 1156 7 . . . cord-009571-mygj2nd4 1157 1 All all DT cord-009571-mygj2nd4 1157 2 of of IN cord-009571-mygj2nd4 1157 3 13 13 CD cord-009571-mygj2nd4 1157 4 children child NNS cord-009571-mygj2nd4 1157 5 tested test VBN cord-009571-mygj2nd4 1157 6 were be VBD cord-009571-mygj2nd4 1157 7 negative negative JJ cord-009571-mygj2nd4 1157 8 for for IN cord-009571-mygj2nd4 1157 9 HLA HLA NNP cord-009571-mygj2nd4 1157 10 - - HYPH cord-009571-mygj2nd4 1157 11 B27 B27 NNP cord-009571-mygj2nd4 1157 12 . . . cord-009571-mygj2nd4 1158 1 Fifteen fifteen CD cord-009571-mygj2nd4 1158 2 children child NNS cord-009571-mygj2nd4 1158 3 with with IN cord-009571-mygj2nd4 1158 4 frequent frequent JJ cord-009571-mygj2nd4 1158 5 and and CC cord-009571-mygj2nd4 1158 6 severe severe JJ cord-009571-mygj2nd4 1158 7 attacks attack NNS cord-009571-mygj2nd4 1159 1 , , , cord-009571-mygj2nd4 1159 2 mean mean VB cord-009571-mygj2nd4 1159 3 age age NN cord-009571-mygj2nd4 1159 4 11.6 11.6 CD cord-009571-mygj2nd4 1159 5 years year NNS cord-009571-mygj2nd4 1160 1 ( ( -LRB- cord-009571-mygj2nd4 1160 2 range range NNP cord-009571-mygj2nd4 1160 3 3 3 CD cord-009571-mygj2nd4 1160 4 - - SYM cord-009571-mygj2nd4 1160 5 18 18 CD cord-009571-mygj2nd4 1160 6 ) ) -RRB- cord-009571-mygj2nd4 1160 7 , , , cord-009571-mygj2nd4 1160 8 were be VBD cord-009571-mygj2nd4 1160 9 selected select VBN cord-009571-mygj2nd4 1160 10 for for IN cord-009571-mygj2nd4 1160 11 colchicine colchicine NNP cord-009571-mygj2nd4 1160 12 therapy therapy NN cord-009571-mygj2nd4 1160 13 . . . cord-009571-mygj2nd4 1161 1 Patients patient NNS cord-009571-mygj2nd4 1161 2 were be VBD cord-009571-mygj2nd4 1161 3 begun begin VBN cord-009571-mygj2nd4 1161 4 on on IN cord-009571-mygj2nd4 1161 5 the the DT cord-009571-mygj2nd4 1161 6 nearest near JJS cord-009571-mygj2nd4 1161 7 whole whole JJ cord-009571-mygj2nd4 1161 8 tablet tablet NN cord-009571-mygj2nd4 1161 9 equivalent equivalent NN cord-009571-mygj2nd4 1161 10 of of IN cord-009571-mygj2nd4 1161 11 1 1 CD cord-009571-mygj2nd4 1161 12 .O .o SYM cord-009571-mygj2nd4 1161 13 mg mg NNP cord-009571-mygj2nd4 1161 14 / / SYM cord-009571-mygj2nd4 1161 15 meter meter NN cord-009571-mygj2nd4 1161 16 squared square VBD cord-009571-mygj2nd4 1161 17 . . . cord-009571-mygj2nd4 1162 1 In in IN cord-009571-mygj2nd4 1162 2 nonresponders nonresponder NNS cord-009571-mygj2nd4 1162 3 , , , cord-009571-mygj2nd4 1162 4 the the DT cord-009571-mygj2nd4 1162 5 dosage dosage NN cord-009571-mygj2nd4 1162 6 was be VBD cord-009571-mygj2nd4 1162 7 raised raise VBN cord-009571-mygj2nd4 1162 8 to to IN cord-009571-mygj2nd4 1162 9 a a DT cord-009571-mygj2nd4 1162 10 maximum maximum NN cord-009571-mygj2nd4 1162 11 of of IN cord-009571-mygj2nd4 1162 12 1.8 1.8 CD cord-009571-mygj2nd4 1162 13 mg mg NNP cord-009571-mygj2nd4 1162 14 / / SYM cord-009571-mygj2nd4 1162 15 day day NN cord-009571-mygj2nd4 1162 16 . . . cord-009571-mygj2nd4 1163 1 Six six CD cord-009571-mygj2nd4 1163 2 patients patient NNS cord-009571-mygj2nd4 1163 3 were be VBD cord-009571-mygj2nd4 1163 4 noncompliant noncompliant JJ cord-009571-mygj2nd4 1163 5 , , , cord-009571-mygj2nd4 1163 6 but but CC cord-009571-mygj2nd4 1163 7 the the DT cord-009571-mygj2nd4 1163 8 remaining remain VBG cord-009571-mygj2nd4 1163 9 9 9 CD cord-009571-mygj2nd4 1163 10 children child NNS cord-009571-mygj2nd4 1163 11 have have VBP cord-009571-mygj2nd4 1163 12 been be VBN cord-009571-mygj2nd4 1163 13 followed follow VBN cord-009571-mygj2nd4 1163 14 for for IN cord-009571-mygj2nd4 1163 15 4 4 CD cord-009571-mygj2nd4 1163 16 - - SYM cord-009571-mygj2nd4 1163 17 52 52 CD cord-009571-mygj2nd4 1163 18 months month NNS cord-009571-mygj2nd4 1163 19 ( ( -LRB- cord-009571-mygj2nd4 1163 20 mean mean VBP cord-009571-mygj2nd4 1163 21 29 29 CD cord-009571-mygj2nd4 1163 22 ) ) -RRB- cord-009571-mygj2nd4 1163 23 on on IN cord-009571-mygj2nd4 1163 24 continuous continuous JJ cord-009571-mygj2nd4 1163 25 colchicine colchicine NNP cord-009571-mygj2nd4 1163 26 therapy therapy NN cord-009571-mygj2nd4 1163 27 . . . cord-009571-mygj2nd4 1164 1 The the DT cord-009571-mygj2nd4 1164 2 mean mean JJ cord-009571-mygj2nd4 1164 3 number number NN cord-009571-mygj2nd4 1164 4 of of IN cord-009571-mygj2nd4 1164 5 attacks attack NNS cord-009571-mygj2nd4 1164 6 for for IN cord-009571-mygj2nd4 1164 7 the the DT cord-009571-mygj2nd4 1164 8 3 3 CD cord-009571-mygj2nd4 1164 9 month month NN cord-009571-mygj2nd4 1164 10 period period NN cord-009571-mygj2nd4 1164 11 prior prior RB cord-009571-mygj2nd4 1165 1 t t NNP cord-009571-mygj2nd4 1165 2 o o NN cord-009571-mygj2nd4 1165 3 initiation initiation NN cord-009571-mygj2nd4 1165 4 of of IN cord-009571-mygj2nd4 1165 5 therapy therapy NN cord-009571-mygj2nd4 1165 6 was be VBD cord-009571-mygj2nd4 1165 7 5.6 5.6 CD cord-009571-mygj2nd4 1165 8 ( ( -LRB- cord-009571-mygj2nd4 1165 9 range range NNP cord-009571-mygj2nd4 1165 10 3 3 CD cord-009571-mygj2nd4 1165 11 - - SYM cord-009571-mygj2nd4 1165 12 12 12 CD cord-009571-mygj2nd4 1165 13 ) ) -RRB- cord-009571-mygj2nd4 1165 14 , , , cord-009571-mygj2nd4 1165 15 but but CC cord-009571-mygj2nd4 1165 16 only only RB cord-009571-mygj2nd4 1165 17 0.6 0.6 CD cord-009571-mygj2nd4 1165 18 ( ( -LRB- cord-009571-mygj2nd4 1165 19 range range NN cord-009571-mygj2nd4 1165 20 0 0 CD cord-009571-mygj2nd4 1165 21 - - SYM cord-009571-mygj2nd4 1165 22 2 2 CD cord-009571-mygj2nd4 1165 23 ) ) -RRB- cord-009571-mygj2nd4 1165 24 for for IN cord-009571-mygj2nd4 1165 25 the the DT cord-009571-mygj2nd4 1165 26 3 3 CD cord-009571-mygj2nd4 1165 27 most most RBS cord-009571-mygj2nd4 1165 28 recent recent JJ cord-009571-mygj2nd4 1165 29 months month NNS cord-009571-mygj2nd4 1165 30 of of IN cord-009571-mygj2nd4 1165 31 colchicine colchicine NN cord-009571-mygj2nd4 1165 32 therapy therapy NN cord-009571-mygj2nd4 1165 33 ( ( -LRB- cord-009571-mygj2nd4 1165 34 P p NN cord-009571-mygj2nd4 1165 35 < < XX cord-009571-mygj2nd4 1165 36 0.0025 0.0025 CD cord-009571-mygj2nd4 1165 37 ) ) -RRB- cord-009571-mygj2nd4 1165 38 . . . cord-009571-mygj2nd4 1166 1 The the DT cord-009571-mygj2nd4 1166 2 only only JJ cord-009571-mygj2nd4 1166 3 side side NN cord-009571-mygj2nd4 1166 4 effect effect NN cord-009571-mygj2nd4 1166 5 was be VBD cord-009571-mygj2nd4 1166 6 transient transient JJ cord-009571-mygj2nd4 1166 7 diarrhea diarrhea NN cord-009571-mygj2nd4 1166 8 , , , cord-009571-mygj2nd4 1166 9 which which WDT cord-009571-mygj2nd4 1166 10 usually usually RB cord-009571-mygj2nd4 1166 11 resolved resolve VBD cord-009571-mygj2nd4 1166 12 without without IN cord-009571-mygj2nd4 1166 13 reduction reduction NN cord-009571-mygj2nd4 1166 14 in in IN cord-009571-mygj2nd4 1166 15 dosage dosage NN cord-009571-mygj2nd4 1166 16 . . . cord-009571-mygj2nd4 1167 1 Although although IN cord-009571-mygj2nd4 1167 2 the the DT cord-009571-mygj2nd4 1167 3 long long JJ cord-009571-mygj2nd4 1167 4 term term NN cord-009571-mygj2nd4 1167 5 safety safety NN cord-009571-mygj2nd4 1167 6 of of IN cord-009571-mygj2nd4 1167 7 colchicine colchicine NN cord-009571-mygj2nd4 1167 8 in in IN cord-009571-mygj2nd4 1167 9 childhood childhood NN cord-009571-mygj2nd4 1167 10 has have VBZ cord-009571-mygj2nd4 1167 11 not not RB cord-009571-mygj2nd4 1167 12 been be VBN cord-009571-mygj2nd4 1167 13 established establish VBN cord-009571-mygj2nd4 1167 14 , , , cord-009571-mygj2nd4 1167 15 n n NN cord-009571-mygj2nd4 1167 16 o o NN cord-009571-mygj2nd4 1168 1 deleterious deleterious JJ cord-009571-mygj2nd4 1168 2 side side NN cord-009571-mygj2nd4 1168 3 effects effect NNS cord-009571-mygj2nd4 1168 4 have have VBP cord-009571-mygj2nd4 1168 5 been be VBN cord-009571-mygj2nd4 1168 6 observed observe VBN cord-009571-mygj2nd4 1168 7 . . . cord-009571-mygj2nd4 1169 1 It -PRON- PRP cord-009571-mygj2nd4 1169 2 appears appear VBZ cord-009571-mygj2nd4 1169 3 that that IN cord-009571-mygj2nd4 1169 4 children child NNS cord-009571-mygj2nd4 1169 5 tolerate tolerate VBP cord-009571-mygj2nd4 1169 6 colchicine colchicine NNP cord-009571-mygj2nd4 1169 7 well well RB cord-009571-mygj2nd4 1169 8 . . . cord-009571-mygj2nd4 1170 1 Colchicine Colchicine NNP cord-009571-mygj2nd4 1170 2 therapy therapy NN cord-009571-mygj2nd4 1170 3 may may MD cord-009571-mygj2nd4 1170 4 allow allow VB cord-009571-mygj2nd4 1170 5 children child NNS cord-009571-mygj2nd4 1170 6 incapacitated incapacitate VBN cord-009571-mygj2nd4 1170 7 by by IN cord-009571-mygj2nd4 1170 8 severe severe JJ cord-009571-mygj2nd4 1170 9 attacks attack NNS cord-009571-mygj2nd4 1170 10 of of IN cord-009571-mygj2nd4 1170 11 F F NNP cord-009571-mygj2nd4 1170 12 M M NNP cord-009571-mygj2nd4 1170 13 F f NN cord-009571-mygj2nd4 1170 14 t t NN cord-009571-mygj2nd4 1170 15 o o NN cord-009571-mygj2nd4 1170 16 assume assume VB cord-009571-mygj2nd4 1170 17 a a DT cord-009571-mygj2nd4 1170 18 nearly nearly RB cord-009571-mygj2nd4 1170 19 normal normal JJ cord-009571-mygj2nd4 1170 20 life life NN cord-009571-mygj2nd4 1170 21 . . . cord-009571-mygj2nd4 1171 1 A a DT cord-009571-mygj2nd4 1171 2 new new JJ cord-009571-mygj2nd4 1171 3 amino amino NN cord-009571-mygj2nd4 1171 4 acid acid NN cord-009571-mygj2nd4 1171 5 , , , cord-009571-mygj2nd4 1171 6 y y NN cord-009571-mygj2nd4 1171 7 - - HYPH cord-009571-mygj2nd4 1171 8 carboxyglutamic carboxyglutamic NNP cord-009571-mygj2nd4 1171 9 acid acid NN cord-009571-mygj2nd4 1171 10 ( ( -LRB- cord-009571-mygj2nd4 1171 11 Gla Gla NNP cord-009571-mygj2nd4 1171 12 ) ) -RRB- cord-009571-mygj2nd4 1171 13 , , , cord-009571-mygj2nd4 1171 14 originally originally RB cord-009571-mygj2nd4 1171 15 discovered discover VBN cord-009571-mygj2nd4 1171 16 in in IN cord-009571-mygj2nd4 1171 17 prothrombin prothrombin NN cord-009571-mygj2nd4 1171 18 where where WRB cord-009571-mygj2nd4 1171 19 Gla Gla NNP cord-009571-mygj2nd4 1171 20 residues residue NNS cord-009571-mygj2nd4 1171 21 are be VBP cord-009571-mygj2nd4 1171 22 sites site NNS cord-009571-mygj2nd4 1171 23 for for IN cord-009571-mygj2nd4 1171 24 specific specific JJ cord-009571-mygj2nd4 1171 25 binding binding NN cord-009571-mygj2nd4 1171 26 of of IN cord-009571-mygj2nd4 1171 27 Ca++ Ca++ NNP cord-009571-mygj2nd4 1171 28 ions ion NNS cord-009571-mygj2nd4 1171 29 , , , cord-009571-mygj2nd4 1171 30 more more RBR cord-009571-mygj2nd4 1171 31 recently recently RB cord-009571-mygj2nd4 1171 32 has have VBZ cord-009571-mygj2nd4 1171 33 been be VBN cord-009571-mygj2nd4 1171 34 identified identify VBN cord-009571-mygj2nd4 1171 35 in in IN cord-009571-mygj2nd4 1171 36 osteocalcin osteocalcin NN cord-009571-mygj2nd4 1171 37 , , , cord-009571-mygj2nd4 1171 38 a a DT cord-009571-mygj2nd4 1171 39 non non JJ cord-009571-mygj2nd4 1171 40 - - JJ cord-009571-mygj2nd4 1171 41 collagenous collagenous JJ cord-009571-mygj2nd4 1171 42 protein protein NN cord-009571-mygj2nd4 1171 43 from from IN cord-009571-mygj2nd4 1171 44 bone bone NN cord-009571-mygj2nd4 1171 45 matrix matrix NN cord-009571-mygj2nd4 1171 46 . . . cord-009571-mygj2nd4 1172 1 Based base VBN cord-009571-mygj2nd4 1172 2 on on IN cord-009571-mygj2nd4 1172 3 amino amino NN cord-009571-mygj2nd4 1172 4 acid acid NN cord-009571-mygj2nd4 1172 5 composition composition NN cord-009571-mygj2nd4 1172 6 and and CC cord-009571-mygj2nd4 1172 7 sequence sequence NN cord-009571-mygj2nd4 1172 8 of of IN cord-009571-mygj2nd4 1172 9 bovine bovine JJ cord-009571-mygj2nd4 1172 10 bone bone NN cord-009571-mygj2nd4 1172 11 Gla Gla NNP cord-009571-mygj2nd4 1172 12 - - HYPH cord-009571-mygj2nd4 1172 13 protein protein NN cord-009571-mygj2nd4 1172 14 , , , cord-009571-mygj2nd4 1172 15 osteocalcin osteocalcin NN cord-009571-mygj2nd4 1172 16 is be VBZ cord-009571-mygj2nd4 1172 17 distinct distinct JJ cord-009571-mygj2nd4 1172 18 from from IN cord-009571-mygj2nd4 1172 19 all all DT cord-009571-mygj2nd4 1172 20 other other JJ cord-009571-mygj2nd4 1172 21 vitamin vitamin NN cord-009571-mygj2nd4 1172 22 K k NN cord-009571-mygj2nd4 1172 23 dependent dependent JJ cord-009571-mygj2nd4 1172 24 clotting clotting NN cord-009571-mygj2nd4 1172 25 proteins protein NNS cord-009571-mygj2nd4 1172 26 ( ( -LRB- cord-009571-mygj2nd4 1172 27 factors factor NNS cord-009571-mygj2nd4 1172 28 11 11 CD cord-009571-mygj2nd4 1172 29 , , , cord-009571-mygj2nd4 1172 30 VII VII NNP cord-009571-mygj2nd4 1172 31 , , , cord-009571-mygj2nd4 1172 32 IX IX NNP cord-009571-mygj2nd4 1172 33 , , , cord-009571-mygj2nd4 1172 34 and and CC cord-009571-mygj2nd4 1172 35 X x LS cord-009571-mygj2nd4 1172 36 ) ) -RRB- cord-009571-mygj2nd4 1172 37 synthesized synthesize VBN cord-009571-mygj2nd4 1172 38 in in IN cord-009571-mygj2nd4 1172 39 the the DT cord-009571-mygj2nd4 1172 40 liver liver NN cord-009571-mygj2nd4 1172 41 . . . cord-009571-mygj2nd4 1173 1 The the DT cord-009571-mygj2nd4 1173 2 posttranslational posttranslational JJ cord-009571-mygj2nd4 1173 3 formation formation NN cord-009571-mygj2nd4 1173 4 of of IN cord-009571-mygj2nd4 1173 5 Gla Gla NNP cord-009571-mygj2nd4 1173 6 , , , cord-009571-mygj2nd4 1173 7 studied study VBD cord-009571-mygj2nd4 1173 8 extensively extensively RB cord-009571-mygj2nd4 1173 9 in in IN cord-009571-mygj2nd4 1173 10 liver liver NN cord-009571-mygj2nd4 1173 11 microsomes microsome NNS cord-009571-mygj2nd4 1173 12 from from IN cord-009571-mygj2nd4 1173 13 warfarin warfarin NN cord-009571-mygj2nd4 1173 14 treated treat VBN cord-009571-mygj2nd4 1173 15 rats rat NNS cord-009571-mygj2nd4 1173 16 , , , cord-009571-mygj2nd4 1173 17 occurs occur VBZ cord-009571-mygj2nd4 1173 18 in in IN cord-009571-mygj2nd4 1173 19 a a DT cord-009571-mygj2nd4 1173 20 vitamin vitamin NN cord-009571-mygj2nd4 1173 21 K k NN cord-009571-mygj2nd4 1173 22 dependent dependent JJ cord-009571-mygj2nd4 1173 23 enzymatic enzymatic JJ cord-009571-mygj2nd4 1173 24 oxidative oxidative JJ cord-009571-mygj2nd4 1173 25 carboxylation carboxylation NN cord-009571-mygj2nd4 1173 26 of of IN cord-009571-mygj2nd4 1173 27 selected select VBN cord-009571-mygj2nd4 1173 28 glutamic glutamic NN cord-009571-mygj2nd4 1173 29 acid acid NN cord-009571-mygj2nd4 1173 30 residues residue NNS cord-009571-mygj2nd4 1173 31 in in IN cord-009571-mygj2nd4 1173 32 prothrombin prothrombin NN cord-009571-mygj2nd4 1173 33 requiring require VBG cord-009571-mygj2nd4 1173 34 bicarbonate bicarbonate NN cord-009571-mygj2nd4 1173 35 ion ion NN cord-009571-mygj2nd4 1173 36 and and CC cord-009571-mygj2nd4 1173 37 NADH NADH NNP cord-009571-mygj2nd4 1173 38 or or CC cord-009571-mygj2nd4 1173 39 chemical chemical NN cord-009571-mygj2nd4 1173 40 reducing reduce VBG cord-009571-mygj2nd4 1173 41 agent agent NN cord-009571-mygj2nd4 1173 42 . . . cord-009571-mygj2nd4 1174 1 To to TO cord-009571-mygj2nd4 1174 2 show show VB cord-009571-mygj2nd4 1174 3 that that IN cord-009571-mygj2nd4 1174 4 Gla Gla NNP cord-009571-mygj2nd4 1174 5 synthesis synthesis NN cord-009571-mygj2nd4 1174 6 occurs occur VBZ cord-009571-mygj2nd4 1174 7 in in IN cord-009571-mygj2nd4 1174 8 bone bone NN cord-009571-mygj2nd4 1174 9 tissue tissue NN cord-009571-mygj2nd4 1174 10 and and CC cord-009571-mygj2nd4 1174 11 that that IN cord-009571-mygj2nd4 1174 12 the the DT cord-009571-mygj2nd4 1174 13 carboxylase carboxylase NN cord-009571-mygj2nd4 1174 14 enzyme enzyme NN cord-009571-mygj2nd4 1174 15 has have VBZ cord-009571-mygj2nd4 1174 16 similar similar JJ cord-009571-mygj2nd4 1174 17 requirements requirement NNS cord-009571-mygj2nd4 1174 18 in in IN cord-009571-mygj2nd4 1174 19 bone bone NN cord-009571-mygj2nd4 1174 20 , , , cord-009571-mygj2nd4 1174 21 microsomes microsome NNS cord-009571-mygj2nd4 1174 22 were be VBD cord-009571-mygj2nd4 1174 23 prepared prepare VBN cord-009571-mygj2nd4 1174 24 from from IN cord-009571-mygj2nd4 1174 25 the the DT cord-009571-mygj2nd4 1174 26 long long JJ cord-009571-mygj2nd4 1174 27 bones bone NNS cord-009571-mygj2nd4 1174 28 of of IN cord-009571-mygj2nd4 1174 29 17 17 CD cord-009571-mygj2nd4 1174 30 day day NN cord-009571-mygj2nd4 1174 31 old old JJ cord-009571-mygj2nd4 1174 32 chick chick NN cord-009571-mygj2nd4 1174 33 embryos embryo NNS cord-009571-mygj2nd4 1174 34 . . . cord-009571-mygj2nd4 1175 1 The the DT cord-009571-mygj2nd4 1175 2 eggs egg NNS cord-009571-mygj2nd4 1175 3 were be VBD cord-009571-mygj2nd4 1175 4 injected inject VBN cord-009571-mygj2nd4 1175 5 at at IN cord-009571-mygj2nd4 1175 6 12 12 CD cord-009571-mygj2nd4 1175 7 , , , cord-009571-mygj2nd4 1175 8 14 14 CD cord-009571-mygj2nd4 1175 9 , , , cord-009571-mygj2nd4 1175 10 and and CC cord-009571-mygj2nd4 1175 11 16 16 CD cord-009571-mygj2nd4 1175 12 days day NNS cord-009571-mygj2nd4 1175 13 with with IN cord-009571-mygj2nd4 1175 14 sodium sodium NN cord-009571-mygj2nd4 1175 15 warfarin warfarin NN cord-009571-mygj2nd4 1175 16 , , , cord-009571-mygj2nd4 1175 17 an an DT cord-009571-mygj2nd4 1175 18 inhibitor inhibitor NN cord-009571-mygj2nd4 1175 19 of of IN cord-009571-mygj2nd4 1175 20 Gla Gla NNP cord-009571-mygj2nd4 1175 21 synthesis synthesis NN cord-009571-mygj2nd4 1175 22 , , , cord-009571-mygj2nd4 1175 23 to to TO cord-009571-mygj2nd4 1175 24 allow allow VB cord-009571-mygj2nd4 1175 25 for for IN cord-009571-mygj2nd4 1175 26 the the DT cord-009571-mygj2nd4 1175 27 accumulation accumulation NN cord-009571-mygj2nd4 1175 28 of of IN cord-009571-mygj2nd4 1175 29 endogenous endogenous JJ cord-009571-mygj2nd4 1175 30 substrate substrate NN cord-009571-mygj2nd4 1175 31 available available JJ cord-009571-mygj2nd4 1175 32 for for IN cord-009571-mygj2nd4 1175 33 specific specific JJ cord-009571-mygj2nd4 1175 34 labeling labeling NN cord-009571-mygj2nd4 1175 35 with with IN cord-009571-mygj2nd4 1175 36 NaH14COB NaH14COB NNP cord-009571-mygj2nd4 1175 37 . . . cord-009571-mygj2nd4 1176 1 The the DT cord-009571-mygj2nd4 1176 2 microsomes microsome NNS cord-009571-mygj2nd4 1176 3 separated separate VBD cord-009571-mygj2nd4 1176 4 from from IN cord-009571-mygj2nd4 1176 5 bone bone NN cord-009571-mygj2nd4 1176 6 homogenates homogenate NNS cord-009571-mygj2nd4 1176 7 by by IN cord-009571-mygj2nd4 1176 8 differential differential JJ cord-009571-mygj2nd4 1176 9 centrifugation centrifugation NN cord-009571-mygj2nd4 1176 10 incorporated incorporate VBN cord-009571-mygj2nd4 1176 11 14C 14c NN cord-009571-mygj2nd4 1176 12 into into IN cord-009571-mygj2nd4 1176 13 Gla Gla NNP cord-009571-mygj2nd4 1176 14 only only RB cord-009571-mygj2nd4 1176 15 in in IN cord-009571-mygj2nd4 1176 16 the the DT cord-009571-mygj2nd4 1176 17 presence presence NN cord-009571-mygj2nd4 1176 18 of of IN cord-009571-mygj2nd4 1176 19 vitamin vitamin NN cord-009571-mygj2nd4 1176 20 K1 K1 NNP cord-009571-mygj2nd4 1176 21 . . . cord-009571-mygj2nd4 1177 1 " " `` cord-009571-mygj2nd4 1177 2 C C NNP cord-009571-mygj2nd4 1177 3 - - HYPH cord-009571-mygj2nd4 1177 4 Gla Gla NNP cord-009571-mygj2nd4 1177 5 was be VBD cord-009571-mygj2nd4 1177 6 identified identify VBN cord-009571-mygj2nd4 1177 7 after after IN cord-009571-mygj2nd4 1177 8 alkaline alkaline JJ cord-009571-mygj2nd4 1177 9 hydrolysis hydrolysis NN cord-009571-mygj2nd4 1177 10 of of IN cord-009571-mygj2nd4 1177 11 the the DT cord-009571-mygj2nd4 1177 12 microsomes microsome NNS cord-009571-mygj2nd4 1177 13 and and CC cord-009571-mygj2nd4 1177 14 separation separation NN cord-009571-mygj2nd4 1177 15 on on IN cord-009571-mygj2nd4 1177 16 an an DT cord-009571-mygj2nd4 1177 17 amino amino NN cord-009571-mygj2nd4 1177 18 acid acid NN cord-009571-mygj2nd4 1177 19 analyzer analyzer NN cord-009571-mygj2nd4 1177 20 . . . cord-009571-mygj2nd4 1178 1 Further further JJ cord-009571-mygj2nd4 1178 2 confirmation confirmation NN cord-009571-mygj2nd4 1178 3 of of IN cord-009571-mygj2nd4 1178 4 " " `` cord-009571-mygj2nd4 1178 5 C C NNP cord-009571-mygj2nd4 1178 6 - - HYPH cord-009571-mygj2nd4 1178 7 Gla Gla NNP cord-009571-mygj2nd4 1178 8 was be VBD cord-009571-mygj2nd4 1178 9 obtained obtain VBN cord-009571-mygj2nd4 1178 10 by by IN cord-009571-mygj2nd4 1178 11 acid acid NNP cord-009571-mygj2nd4 1178 12 hydrol hydrol NNP cord-009571-mygj2nd4 1178 13 - - HYPH cord-009571-mygj2nd4 1178 14 ysis ysis NNP cord-009571-mygj2nd4 1178 15 of of IN cord-009571-mygj2nd4 1178 16 the the DT cord-009571-mygj2nd4 1178 17 putative putative JJ cord-009571-mygj2nd4 1178 18 Gla Gla NNP cord-009571-mygj2nd4 1178 19 component component NN cord-009571-mygj2nd4 1178 20 resulting result VBG cord-009571-mygj2nd4 1178 21 in in IN cord-009571-mygj2nd4 1178 22 decarboxylation decarboxylation NN cord-009571-mygj2nd4 1178 23 to to IN cord-009571-mygj2nd4 1178 24 glutamic glutamic NN cord-009571-mygj2nd4 1178 25 acid acid NN cord-009571-mygj2nd4 1178 26 and and CC cord-009571-mygj2nd4 1178 27 recovery recovery NN cord-009571-mygj2nd4 1178 28 of of IN cord-009571-mygj2nd4 1178 29 approximately approximately RB cord-009571-mygj2nd4 1178 30 50 50 CD cord-009571-mygj2nd4 1178 31 % % NN cord-009571-mygj2nd4 1178 32 of of IN cord-009571-mygj2nd4 1178 33 the the DT cord-009571-mygj2nd4 1178 34 incorporated incorporated JJ cord-009571-mygj2nd4 1178 35 radioactivity radioactivity NN cord-009571-mygj2nd4 1178 36 in in IN cord-009571-mygj2nd4 1178 37 glutamic glutamic NN cord-009571-mygj2nd4 1178 38 acid acid NN cord-009571-mygj2nd4 1178 39 . . . cord-009571-mygj2nd4 1179 1 The the DT cord-009571-mygj2nd4 1179 2 posttranslational posttranslational JJ cord-009571-mygj2nd4 1179 3 enzymatic enzymatic JJ cord-009571-mygj2nd4 1179 4 generation generation NN cord-009571-mygj2nd4 1179 5 of of IN cord-009571-mygj2nd4 1179 6 specific specific JJ cord-009571-mygj2nd4 1179 7 calcium calcium NN cord-009571-mygj2nd4 1179 8 binding bind VBG cord-009571-mygj2nd4 1179 9 sites site NNS cord-009571-mygj2nd4 1179 10 in in IN cord-009571-mygj2nd4 1179 11 bone bone NN cord-009571-mygj2nd4 1179 12 suggests suggest VBZ cord-009571-mygj2nd4 1179 13 that that IN cord-009571-mygj2nd4 1179 14 the the DT cord-009571-mygj2nd4 1179 15 vitamin vitamin NN cord-009571-mygj2nd4 1179 16 K K NNP cord-009571-mygj2nd4 1179 17 dependent dependent JJ cord-009571-mygj2nd4 1179 18 carboxylation carboxylation NN cord-009571-mygj2nd4 1179 19 reaction reaction NN cord-009571-mygj2nd4 1179 20 may may MD cord-009571-mygj2nd4 1179 21 have have VB cord-009571-mygj2nd4 1179 22 a a DT cord-009571-mygj2nd4 1179 23 possible possible JJ cord-009571-mygj2nd4 1179 24 role role NN cord-009571-mygj2nd4 1179 25 in in IN cord-009571-mygj2nd4 1179 26 regulating regulate VBG cord-009571-mygj2nd4 1179 27 mineral mineral NN cord-009571-mygj2nd4 1179 28 deposition deposition NN cord-009571-mygj2nd4 1179 29 in in IN cord-009571-mygj2nd4 1179 30 calcified calcified JJ cord-009571-mygj2nd4 1179 31 tissues tissue NNS cord-009571-mygj2nd4 1179 32 . . . cord-009571-mygj2nd4 1180 1 Since since IN cord-009571-mygj2nd4 1180 2 the the DT cord-009571-mygj2nd4 1180 3 formation formation NN cord-009571-mygj2nd4 1180 4 of of IN cord-009571-mygj2nd4 1180 5 a a DT cord-009571-mygj2nd4 1180 6 specific specific JJ cord-009571-mygj2nd4 1180 7 calcium calcium NN cord-009571-mygj2nd4 1180 8 binding bind VBG cord-009571-mygj2nd4 1180 9 amino amino NN cord-009571-mygj2nd4 1180 10 acid acid NN cord-009571-mygj2nd4 1180 11 in in IN cord-009571-mygj2nd4 1180 12 bone bone NN cord-009571-mygj2nd4 1180 13 is be VBZ cord-009571-mygj2nd4 1180 14 vitamin vitamin NN cord-009571-mygj2nd4 1180 15 K K NNP cord-009571-mygj2nd4 1180 16 dependent dependent JJ cord-009571-mygj2nd4 1180 17 , , , cord-009571-mygj2nd4 1180 18 anomalies anomaly NNS cord-009571-mygj2nd4 1180 19 might may MD cord-009571-mygj2nd4 1180 20 be be VB cord-009571-mygj2nd4 1180 21 expected expect VBN cord-009571-mygj2nd4 1180 22 to to TO cord-009571-mygj2nd4 1180 23 occur occur VB cord-009571-mygj2nd4 1180 24 in in IN cord-009571-mygj2nd4 1180 25 mineralized mineralized JJ cord-009571-mygj2nd4 1180 26 tissues tissue NNS cord-009571-mygj2nd4 1180 27 under under IN cord-009571-mygj2nd4 1180 28 conditions condition NNS cord-009571-mygj2nd4 1180 29 of of IN cord-009571-mygj2nd4 1180 30 vitamin vitamin NN cord-009571-mygj2nd4 1180 31 K K NNP cord-009571-mygj2nd4 1180 32 deficiency deficiency NN cord-009571-mygj2nd4 1180 33 or or CC cord-009571-mygj2nd4 1180 34 anticoagulant anticoagulant NN cord-009571-mygj2nd4 1180 35 therapy therapy NN cord-009571-mygj2nd4 1180 36 . . . cord-009571-mygj2nd4 1181 1 Of of IN cord-009571-mygj2nd4 1181 2 significance significance NN cord-009571-mygj2nd4 1181 3 is be VBZ cord-009571-mygj2nd4 1181 4 the the DT cord-009571-mygj2nd4 1181 5 finding finding NN cord-009571-mygj2nd4 1181 6 of of IN cord-009571-mygj2nd4 1181 7 Gla Gla NNP cord-009571-mygj2nd4 1181 8 - - HYPH cord-009571-mygj2nd4 1181 9 containing contain VBG cord-009571-mygj2nd4 1181 10 proteins protein NNS cord-009571-mygj2nd4 1181 11 in in IN cord-009571-mygj2nd4 1181 12 ectopic ectopic JJ cord-009571-mygj2nd4 1181 13 calcifications calcification NNS cord-009571-mygj2nd4 1181 14 ( ( -LRB- cord-009571-mygj2nd4 1181 15 subcutaneous subcutaneous JJ cord-009571-mygj2nd4 1181 16 scleroderma scleroderma NNS cord-009571-mygj2nd4 1181 17 and and CC cord-009571-mygj2nd4 1181 18 dermatomyositis dermatomyositis NN cord-009571-mygj2nd4 1181 19 plaques plaque NNS cord-009571-mygj2nd4 1181 20 , , , cord-009571-mygj2nd4 1181 21 atheromatous atheromatous JJ cord-009571-mygj2nd4 1181 22 plaque plaque NN cord-009571-mygj2nd4 1181 23 ) ) -RRB- cord-009571-mygj2nd4 1181 24 which which WDT cord-009571-mygj2nd4 1181 25 suggests suggest VBZ cord-009571-mygj2nd4 1181 26 Gla Gla NNP cord-009571-mygj2nd4 1181 27 may may MD cord-009571-mygj2nd4 1181 28 be be VB cord-009571-mygj2nd4 1181 29 important important JJ cord-009571-mygj2nd4 1181 30 in in IN cord-009571-mygj2nd4 1181 31 the the DT cord-009571-mygj2nd4 1181 32 formation formation NN cord-009571-mygj2nd4 1181 33 and and CC cord-009571-mygj2nd4 1181 34 resorption resorption NN cord-009571-mygj2nd4 1181 35 of of IN cord-009571-mygj2nd4 1181 36 bone bone NN cord-009571-mygj2nd4 1181 37 in in IN cord-009571-mygj2nd4 1181 38 a a DT cord-009571-mygj2nd4 1181 39 wide wide JJ cord-009571-mygj2nd4 1181 40 variety variety NN cord-009571-mygj2nd4 1181 41 of of IN cord-009571-mygj2nd4 1181 42 disorders disorder NNS cord-009571-mygj2nd4 1181 43 . . . cord-009571-mygj2nd4 1182 1 A a DT cord-009571-mygj2nd4 1182 2 retrospective retrospective JJ cord-009571-mygj2nd4 1182 3 study study NN cord-009571-mygj2nd4 1182 4 was be VBD cord-009571-mygj2nd4 1182 5 instituted institute VBN cord-009571-mygj2nd4 1182 6 on on IN cord-009571-mygj2nd4 1182 7 10 10 CD cord-009571-mygj2nd4 1182 8 patients patient NNS cord-009571-mygj2nd4 1182 9 in in IN cord-009571-mygj2nd4 1182 10 the the DT cord-009571-mygj2nd4 1182 11 UCLA UCLA NNP cord-009571-mygj2nd4 1182 12 lupus lupus NN cord-009571-mygj2nd4 1182 13 nephritis nephritis NN cord-009571-mygj2nd4 1182 14 clinic clinic NN cord-009571-mygj2nd4 1182 15 in in IN cord-009571-mygj2nd4 1182 16 an an DT cord-009571-mygj2nd4 1182 17 attempt attempt NN cord-009571-mygj2nd4 1182 18 to to TO cord-009571-mygj2nd4 1182 19 determine determine VB cord-009571-mygj2nd4 1182 20 the the DT cord-009571-mygj2nd4 1182 21 ability ability NN cord-009571-mygj2nd4 1182 22 of of IN cord-009571-mygj2nd4 1182 23 three three CD cord-009571-mygj2nd4 1182 24 serologic serologic JJ cord-009571-mygj2nd4 1182 25 indicators indicator NNS cord-009571-mygj2nd4 1182 26 - - : cord-009571-mygj2nd4 1182 27 specifically specifically RB cord-009571-mygj2nd4 1182 28 immune immune JJ cord-009571-mygj2nd4 1182 29 complexes complex NNS cord-009571-mygj2nd4 1182 30 ( ( -LRB- cord-009571-mygj2nd4 1182 31 IC IC NNP cord-009571-mygj2nd4 1182 32 ) ) -RRB- cord-009571-mygj2nd4 1182 33 , , , cord-009571-mygj2nd4 1182 34 anti anti JJ cord-009571-mygj2nd4 1182 35 - - JJ cord-009571-mygj2nd4 1182 36 DNA dna JJ cord-009571-mygj2nd4 1182 37 antibodies antibody NNS cord-009571-mygj2nd4 1182 38 ( ( -LRB- cord-009571-mygj2nd4 1182 39 DNA dna NN cord-009571-mygj2nd4 1182 40 - - HYPH cord-009571-mygj2nd4 1182 41 ab ab NN cord-009571-mygj2nd4 1182 42 ) ) -RRB- cord-009571-mygj2nd4 1182 43 , , , cord-009571-mygj2nd4 1182 44 and and CC cord-009571-mygj2nd4 1182 45 C3-to C3-to NNP cord-009571-mygj2nd4 1182 46 predict predict VBP cord-009571-mygj2nd4 1182 47 the the DT cord-009571-mygj2nd4 1182 48 activity activity NN cord-009571-mygj2nd4 1182 49 of of IN cord-009571-mygj2nd4 1182 50 SLE SLE NNP cord-009571-mygj2nd4 1182 51 renal renal JJ cord-009571-mygj2nd4 1182 52 disease disease NN cord-009571-mygj2nd4 1182 53 as as IN cord-009571-mygj2nd4 1182 54 indicated indicate VBN cord-009571-mygj2nd4 1182 55 by by IN cord-009571-mygj2nd4 1182 56 changes change NNS cord-009571-mygj2nd4 1182 57 in in IN cord-009571-mygj2nd4 1182 58 24 24 CD cord-009571-mygj2nd4 1182 59 hour hour NN cord-009571-mygj2nd4 1182 60 proteinuria proteinuria NN cord-009571-mygj2nd4 1182 61 , , , cord-009571-mygj2nd4 1182 62 serum serum NN cord-009571-mygj2nd4 1182 63 creatinine creatinine NN cord-009571-mygj2nd4 1182 64 , , , cord-009571-mygj2nd4 1182 65 and and CC cord-009571-mygj2nd4 1182 66 creatinine creatinine NN cord-009571-mygj2nd4 1182 67 clearance clearance NN cord-009571-mygj2nd4 1182 68 . . . cord-009571-mygj2nd4 1183 1 We -PRON- PRP cord-009571-mygj2nd4 1183 2 chose choose VBD cord-009571-mygj2nd4 1183 3 not not RB cord-009571-mygj2nd4 1183 4 to to TO cord-009571-mygj2nd4 1183 5 assess assess VB cord-009571-mygj2nd4 1183 6 urinary urinary JJ cord-009571-mygj2nd4 1183 7 sediment sediment NN cord-009571-mygj2nd4 1183 8 because because IN cord-009571-mygj2nd4 1183 9 of of IN cord-009571-mygj2nd4 1183 10 difficulty difficulty NN cord-009571-mygj2nd4 1183 11 in in IN cord-009571-mygj2nd4 1183 12 quantitating quantitate VBG cord-009571-mygj2nd4 1183 13 terms term NNS cord-009571-mygj2nd4 1183 14 such such JJ cord-009571-mygj2nd4 1183 15 as as IN cord-009571-mygj2nd4 1183 16 " " `` cord-009571-mygj2nd4 1183 17 rare rare JJ cord-009571-mygj2nd4 1183 18 , , , cord-009571-mygj2nd4 1183 19 " " '' cord-009571-mygj2nd4 1183 20 " " `` cord-009571-mygj2nd4 1183 21 occasional occasional JJ cord-009571-mygj2nd4 1183 22 , , , cord-009571-mygj2nd4 1183 23 ' ' '' cord-009571-mygj2nd4 1183 24 ' ' '' cord-009571-mygj2nd4 1183 25 and and CC cord-009571-mygj2nd4 1183 26 " " `` cord-009571-mygj2nd4 1183 27 full full JJ cord-009571-mygj2nd4 1183 28 field field NN cord-009571-mygj2nd4 1183 29 " " '' cord-009571-mygj2nd4 1183 30 as as IN cord-009571-mygj2nd4 1183 31 used use VBN cord-009571-mygj2nd4 1183 32 by by IN cord-009571-mygj2nd4 1183 33 different different JJ cord-009571-mygj2nd4 1183 34 observers observer NNS cord-009571-mygj2nd4 1183 35 . . . cord-009571-mygj2nd4 1184 1 Patients patient NNS cord-009571-mygj2nd4 1184 2 ' ' POS cord-009571-mygj2nd4 1184 3 records record NNS cord-009571-mygj2nd4 1184 4 and and CC cord-009571-mygj2nd4 1184 5 serum serum NN cord-009571-mygj2nd4 1184 6 samples sample NNS cord-009571-mygj2nd4 1184 7 from from IN cord-009571-mygj2nd4 1184 8 the the DT cord-009571-mygj2nd4 1184 9 period period NN cord-009571-mygj2nd4 1184 10 1975 1975 CD cord-009571-mygj2nd4 1184 11 - - SYM cord-009571-mygj2nd4 1184 12 1977 1977 CD cord-009571-mygj2nd4 1184 13 were be VBD cord-009571-mygj2nd4 1184 14 employed employ VBN cord-009571-mygj2nd4 1184 15 . . . cord-009571-mygj2nd4 1185 1 The the DT cord-009571-mygj2nd4 1185 2 mean mean JJ cord-009571-mygj2nd4 1185 3 number number NN cord-009571-mygj2nd4 1185 4 of of IN cord-009571-mygj2nd4 1185 5 matched match VBN cord-009571-mygj2nd4 1185 6 clinical clinical JJ cord-009571-mygj2nd4 1185 7 samples sample NNS cord-009571-mygj2nd4 1185 8 per per IN cord-009571-mygj2nd4 1185 9 patient patient NN cord-009571-mygj2nd4 1185 10 was be VBD cord-009571-mygj2nd4 1185 11 20 20 CD cord-009571-mygj2nd4 1185 12 with with IN cord-009571-mygj2nd4 1185 13 a a DT cord-009571-mygj2nd4 1185 14 range range NN cord-009571-mygj2nd4 1185 15 of of IN cord-009571-mygj2nd4 1185 16 9 9 CD cord-009571-mygj2nd4 1185 17 - - SYM cord-009571-mygj2nd4 1185 18 28 28 CD cord-009571-mygj2nd4 1185 19 . . . cord-009571-mygj2nd4 1186 1 Similarly similarly RB cord-009571-mygj2nd4 1186 2 , , , cord-009571-mygj2nd4 1186 3 the the DT cord-009571-mygj2nd4 1186 4 mean mean JJ cord-009571-mygj2nd4 1186 5 number number NN cord-009571-mygj2nd4 1186 6 of of IN cord-009571-mygj2nd4 1186 7 matched match VBN cord-009571-mygj2nd4 1186 8 serologic serologic JJ cord-009571-mygj2nd4 1186 9 samples sample NNS cord-009571-mygj2nd4 1186 10 per per IN cord-009571-mygj2nd4 1186 11 patient patient NN cord-009571-mygj2nd4 1186 12 was be VBD cord-009571-mygj2nd4 1186 13 16 16 CD cord-009571-mygj2nd4 1186 14 with with IN cord-009571-mygj2nd4 1186 15 a a DT cord-009571-mygj2nd4 1186 16 range range NN cord-009571-mygj2nd4 1186 17 of of IN cord-009571-mygj2nd4 1186 18 8 8 CD cord-009571-mygj2nd4 1186 19 - - SYM cord-009571-mygj2nd4 1186 20 24 24 CD cord-009571-mygj2nd4 1186 21 . . . cord-009571-mygj2nd4 1187 1 " " `` cord-009571-mygj2nd4 1187 2 Normal normal JJ cord-009571-mygj2nd4 1187 3 " " '' cord-009571-mygj2nd4 1187 4 daily daily JJ cord-009571-mygj2nd4 1187 5 or or CC cord-009571-mygj2nd4 1187 6 short short JJ cord-009571-mygj2nd4 1187 7 term term NN cord-009571-mygj2nd4 1187 8 variation variation NN cord-009571-mygj2nd4 1187 9 for for IN cord-009571-mygj2nd4 1187 10 each each DT cord-009571-mygj2nd4 1187 11 clinical clinical JJ cord-009571-mygj2nd4 1187 12 and and CC cord-009571-mygj2nd4 1187 13 serologic serologic JJ cord-009571-mygj2nd4 1187 14 parameter parameter NN cord-009571-mygj2nd4 1187 15 was be VBD cord-009571-mygj2nd4 1187 16 assessed assess VBN cord-009571-mygj2nd4 1187 17 from from IN cord-009571-mygj2nd4 1187 18 paired pair VBN cord-009571-mygj2nd4 1187 19 samples sample NNS cord-009571-mygj2nd4 1187 20 taken take VBN cord-009571-mygj2nd4 1187 21 within within IN cord-009571-mygj2nd4 1187 22 1 1 CD cord-009571-mygj2nd4 1187 23 - - SYM cord-009571-mygj2nd4 1187 24 7 7 CD cord-009571-mygj2nd4 1187 25 days day NNS cord-009571-mygj2nd4 1187 26 of of IN cord-009571-mygj2nd4 1187 27 each each DT cord-009571-mygj2nd4 1187 28 other other JJ cord-009571-mygj2nd4 1187 29 . . . cord-009571-mygj2nd4 1188 1 These these DT cord-009571-mygj2nd4 1188 2 " " `` cord-009571-mygj2nd4 1188 3 normal normal JJ cord-009571-mygj2nd4 1188 4 " " '' cord-009571-mygj2nd4 1188 5 values value NNS cord-009571-mygj2nd4 1188 6 were be VBD cord-009571-mygj2nd4 1188 7 then then RB cord-009571-mygj2nd4 1188 8 used use VBN cord-009571-mygj2nd4 1188 9 as as IN cord-009571-mygj2nd4 1188 10 a a DT cord-009571-mygj2nd4 1188 11 baseline baseline NN cord-009571-mygj2nd4 1188 12 , , , cord-009571-mygj2nd4 1188 13 variations variation NNS cord-009571-mygj2nd4 1188 14 from from IN cord-009571-mygj2nd4 1188 15 which which WDT cord-009571-mygj2nd4 1188 16 could could MD cord-009571-mygj2nd4 1188 17 be be VB cord-009571-mygj2nd4 1188 18 tested test VBN cord-009571-mygj2nd4 1188 19 for for IN cord-009571-mygj2nd4 1188 20 abnormality abnormality NN cord-009571-mygj2nd4 1188 21 by by IN cord-009571-mygj2nd4 1188 22 statistical statistical JJ cord-009571-mygj2nd4 1188 23 techniques technique NNS cord-009571-mygj2nd4 1188 24 . . . cord-009571-mygj2nd4 1189 1 By by IN cord-009571-mygj2nd4 1189 2 use use NN cord-009571-mygj2nd4 1189 3 of of IN cord-009571-mygj2nd4 1189 4 simple simple JJ cord-009571-mygj2nd4 1189 5 regression regression NN cord-009571-mygj2nd4 1189 6 analysis analysis NN cord-009571-mygj2nd4 1189 7 it -PRON- PRP cord-009571-mygj2nd4 1189 8 was be VBD cord-009571-mygj2nd4 1189 9 noted note VBN cord-009571-mygj2nd4 1189 10 that that IN cord-009571-mygj2nd4 1189 11 IC IC NNP cord-009571-mygj2nd4 1189 12 as as IN cord-009571-mygj2nd4 1189 13 determined determine VBN cord-009571-mygj2nd4 1189 14 by by IN cord-009571-mygj2nd4 1189 15 4 4 CD cord-009571-mygj2nd4 1189 16 % % NN cord-009571-mygj2nd4 1189 17 polyethylene polyethylene NN cord-009571-mygj2nd4 1189 18 glycol glycol NN cord-009571-mygj2nd4 1189 19 precipitation precipitation NN cord-009571-mygj2nd4 1189 20 correlated correlate VBN cord-009571-mygj2nd4 1189 21 better well RBR cord-009571-mygj2nd4 1189 22 than than IN cord-009571-mygj2nd4 1189 23 either either CC cord-009571-mygj2nd4 1189 24 DNA DNA NNP cord-009571-mygj2nd4 1189 25 or or CC cord-009571-mygj2nd4 1189 26 C3 c3 NN cord-009571-mygj2nd4 1189 27 with with IN cord-009571-mygj2nd4 1189 28 clinical clinical JJ cord-009571-mygj2nd4 1189 29 parameters parameter NNS cord-009571-mygj2nd4 1189 30 . . . cord-009571-mygj2nd4 1190 1 Intriguingly intriguingly RB cord-009571-mygj2nd4 1190 2 , , , cord-009571-mygj2nd4 1190 3 IC IC NNP cord-009571-mygj2nd4 1190 4 correlated correlate VBD cord-009571-mygj2nd4 1190 5 with with IN cord-009571-mygj2nd4 1190 6 neither neither DT cord-009571-mygj2nd4 1190 7 DNA dna NN cord-009571-mygj2nd4 1190 8 - - HYPH cord-009571-mygj2nd4 1190 9 ab ab NN cord-009571-mygj2nd4 1190 10 or or CC cord-009571-mygj2nd4 1190 11 C3 c3 NN cord-009571-mygj2nd4 1190 12 . . . cord-009571-mygj2nd4 1191 1 More more RBR cord-009571-mygj2nd4 1191 2 importantly importantly RB cord-009571-mygj2nd4 1191 3 , , , cord-009571-mygj2nd4 1191 4 when when WRB cord-009571-mygj2nd4 1191 5 attempts attempt NNS cord-009571-mygj2nd4 1191 6 were be VBD cord-009571-mygj2nd4 1191 7 made make VBN cord-009571-mygj2nd4 1191 8 to to TO cord-009571-mygj2nd4 1191 9 predict predict VB cord-009571-mygj2nd4 1191 10 deterioration deterioration NN cord-009571-mygj2nd4 1191 11 of of IN cord-009571-mygj2nd4 1191 12 clinical clinical JJ cord-009571-mygj2nd4 1191 13 parameters parameter NNS cord-009571-mygj2nd4 1191 14 3 3 CD cord-009571-mygj2nd4 1191 15 - - SYM cord-009571-mygj2nd4 1191 16 5 5 CD cord-009571-mygj2nd4 1191 17 weeks week NNS cord-009571-mygj2nd4 1191 18 after after IN cord-009571-mygj2nd4 1191 19 either either CC cord-009571-mygj2nd4 1191 20 a a DT cord-009571-mygj2nd4 1191 21 single single JJ cord-009571-mygj2nd4 1191 22 abnormal abnormal JJ cord-009571-mygj2nd4 1191 23 serologic serologic NN cord-009571-mygj2nd4 1191 24 determination determination NN cord-009571-mygj2nd4 1191 25 or or CC cord-009571-mygj2nd4 1191 26 after after IN cord-009571-mygj2nd4 1191 27 paired paired JJ cord-009571-mygj2nd4 1191 28 determinations determination NNS cord-009571-mygj2nd4 1191 29 of of IN cord-009571-mygj2nd4 1191 30 serologic serologic JJ cord-009571-mygj2nd4 1191 31 parameters parameter NNS cord-009571-mygj2nd4 1191 32 demonstrating demonstrate VBG cord-009571-mygj2nd4 1191 33 significant significant JJ cord-009571-mygj2nd4 1191 34 deterioration deterioration NN cord-009571-mygj2nd4 1191 35 , , , cord-009571-mygj2nd4 1191 36 no no DT cord-009571-mygj2nd4 1191 37 test test NN cord-009571-mygj2nd4 1191 38 or or CC cord-009571-mygj2nd4 1191 39 combination combination NN cord-009571-mygj2nd4 1191 40 of of IN cord-009571-mygj2nd4 1191 41 tests test NNS cord-009571-mygj2nd4 1191 42 produced produce VBD cord-009571-mygj2nd4 1191 43 less less JJR cord-009571-mygj2nd4 1191 44 than than IN cord-009571-mygj2nd4 1191 45 a a DT cord-009571-mygj2nd4 1191 46 50 50 CD cord-009571-mygj2nd4 1191 47 % % NN cord-009571-mygj2nd4 1191 48 false false JJ cord-009571-mygj2nd4 1191 49 positive positive JJ cord-009571-mygj2nd4 1191 50 rate rate NN cord-009571-mygj2nd4 1191 51 . . . cord-009571-mygj2nd4 1192 1 However however RB cord-009571-mygj2nd4 1192 2 , , , cord-009571-mygj2nd4 1192 3 all all DT cord-009571-mygj2nd4 1192 4 tests test NNS cord-009571-mygj2nd4 1192 5 were be VBD cord-009571-mygj2nd4 1192 6 capable capable JJ cord-009571-mygj2nd4 1192 7 of of IN cord-009571-mygj2nd4 1192 8 predicting predict VBG cord-009571-mygj2nd4 1192 9 stability stability NN cord-009571-mygj2nd4 1192 10 or or CC cord-009571-mygj2nd4 1192 11 improvement improvement NN cord-009571-mygj2nd4 1192 12 of of IN cord-009571-mygj2nd4 1192 13 clinical clinical JJ cord-009571-mygj2nd4 1192 14 parameters parameter NNS cord-009571-mygj2nd4 1192 15 with with IN cord-009571-mygj2nd4 1192 16 a a DT cord-009571-mygj2nd4 1192 17 true true JJ cord-009571-mygj2nd4 1192 18 negative negative JJ cord-009571-mygj2nd4 1192 19 rate rate NN cord-009571-mygj2nd4 1192 20 that that WDT cord-009571-mygj2nd4 1192 21 averaged average VBD cord-009571-mygj2nd4 1192 22 92.3 92.3 CD cord-009571-mygj2nd4 1192 23 % % NN cord-009571-mygj2nd4 1192 24 for for IN cord-009571-mygj2nd4 1192 25 IC IC NNP cord-009571-mygj2nd4 1192 26 , , , cord-009571-mygj2nd4 1192 27 91.4 91.4 CD cord-009571-mygj2nd4 1192 28 % % NN cord-009571-mygj2nd4 1192 29 for for IN cord-009571-mygj2nd4 1192 30 C3 C3 NNP cord-009571-mygj2nd4 1192 31 , , , cord-009571-mygj2nd4 1192 32 90.8 90.8 CD cord-009571-mygj2nd4 1192 33 % % NN cord-009571-mygj2nd4 1192 34 for for IN cord-009571-mygj2nd4 1192 35 DNA dna NN cord-009571-mygj2nd4 1192 36 - - HYPH cord-009571-mygj2nd4 1192 37 ab ab NN cord-009571-mygj2nd4 1192 38 . . . cord-009571-mygj2nd4 1193 1 No no DT cord-009571-mygj2nd4 1193 2 combination combination NN cord-009571-mygj2nd4 1193 3 of of IN cord-009571-mygj2nd4 1193 4 tests test NNS cord-009571-mygj2nd4 1193 5 improved improve VBD cord-009571-mygj2nd4 1193 6 these these DT cord-009571-mygj2nd4 1193 7 rates rate NNS cord-009571-mygj2nd4 1193 8 . . . cord-009571-mygj2nd4 1194 1 Pyogenic pyogenic NN cord-009571-mygj2nd4 1194 2 infection infection NN cord-009571-mygj2nd4 1194 3 originating originate VBG cord-009571-mygj2nd4 1194 4 within within IN cord-009571-mygj2nd4 1194 5 the the DT cord-009571-mygj2nd4 1194 6 intervertebral intervertebral JJ cord-009571-mygj2nd4 1194 7 disc disc NN cord-009571-mygj2nd4 1194 8 space space NN cord-009571-mygj2nd4 1194 9 , , , cord-009571-mygj2nd4 1194 10 once once RB cord-009571-mygj2nd4 1194 11 thought think VBD cord-009571-mygj2nd4 1194 12 to to TO cord-009571-mygj2nd4 1194 13 be be VB cord-009571-mygj2nd4 1194 14 uncommon uncommon JJ cord-009571-mygj2nd4 1194 15 , , , cord-009571-mygj2nd4 1194 16 is be VBZ cord-009571-mygj2nd4 1194 17 becoming become VBG cord-009571-mygj2nd4 1194 18 increasingly increasingly RB cord-009571-mygj2nd4 1194 19 recognized recognize VBN cord-009571-mygj2nd4 1194 20 . . . cord-009571-mygj2nd4 1195 1 We -PRON- PRP cord-009571-mygj2nd4 1195 2 report report VBP cord-009571-mygj2nd4 1195 3 the the DT cord-009571-mygj2nd4 1195 4 clinical clinical JJ cord-009571-mygj2nd4 1195 5 findings finding NNS cord-009571-mygj2nd4 1195 6 in in IN cord-009571-mygj2nd4 1195 7 15 15 CD cord-009571-mygj2nd4 1195 8 adult adult NN cord-009571-mygj2nd4 1195 9 patients patient NNS cord-009571-mygj2nd4 1195 10 with with IN cord-009571-mygj2nd4 1195 11 non non JJ cord-009571-mygj2nd4 1195 12 - - JJ cord-009571-mygj2nd4 1195 13 tuberculous tuberculous JJ cord-009571-mygj2nd4 1195 14 pyogenic pyogenic JJ cord-009571-mygj2nd4 1195 15 infection infection NN cord-009571-mygj2nd4 1195 16 of of IN cord-009571-mygj2nd4 1195 17 the the DT cord-009571-mygj2nd4 1195 18 intervertebral intervertebral JJ cord-009571-mygj2nd4 1195 19 disc disc NN cord-009571-mygj2nd4 1195 20 occurring occur VBG cord-009571-mygj2nd4 1195 21 in in IN cord-009571-mygj2nd4 1195 22 two two CD cord-009571-mygj2nd4 1195 23 teaching teaching NN cord-009571-mygj2nd4 1195 24 hospitals hospital NNS cord-009571-mygj2nd4 1195 25 over over IN cord-009571-mygj2nd4 1195 26 an an DT cord-009571-mygj2nd4 1195 27 18 18 CD cord-009571-mygj2nd4 1195 28 month month NN cord-009571-mygj2nd4 1195 29 period period NN cord-009571-mygj2nd4 1195 30 . . . cord-009571-mygj2nd4 1196 1 Chills chill NNS cord-009571-mygj2nd4 1196 2 , , , cord-009571-mygj2nd4 1196 3 rigors rigor NNS cord-009571-mygj2nd4 1196 4 , , , cord-009571-mygj2nd4 1196 5 and and CC cord-009571-mygj2nd4 1196 6 low low JJ cord-009571-mygj2nd4 1196 7 grade grade NN cord-009571-mygj2nd4 1196 8 fever fever NN cord-009571-mygj2nd4 1196 9 were be VBD cord-009571-mygj2nd4 1196 10 common common JJ cord-009571-mygj2nd4 1196 11 prodromal prodromal JJ cord-009571-mygj2nd4 1196 12 complaints complaint NNS cord-009571-mygj2nd4 1196 13 ( ( -LRB- cord-009571-mygj2nd4 1196 14 7 7 CD cord-009571-mygj2nd4 1196 15 : : SYM cord-009571-mygj2nd4 1196 16 lS ls XX cord-009571-mygj2nd4 1196 17 ) ) -RRB- cord-009571-mygj2nd4 1196 18 . . . cord-009571-mygj2nd4 1197 1 The the DT cord-009571-mygj2nd4 1197 2 acute acute JJ cord-009571-mygj2nd4 1197 3 onset onset NN cord-009571-mygj2nd4 1197 4 of of IN cord-009571-mygj2nd4 1197 5 back back NN cord-009571-mygj2nd4 1197 6 and and CC cord-009571-mygj2nd4 1197 7 neck neck NN cord-009571-mygj2nd4 1197 8 pain pain NN cord-009571-mygj2nd4 1197 9 ( ( -LRB- cord-009571-mygj2nd4 1197 10 14 14 CD cord-009571-mygj2nd4 1197 11 : : : cord-009571-mygj2nd4 1197 12 lS ls XX cord-009571-mygj2nd4 1197 13 ) ) -RRB- cord-009571-mygj2nd4 1197 14 with with IN cord-009571-mygj2nd4 1197 15 point point NN cord-009571-mygj2nd4 1197 16 tenderness tenderness NN cord-009571-mygj2nd4 1197 17 over over IN cord-009571-mygj2nd4 1197 18 the the DT cord-009571-mygj2nd4 1197 19 involved involved JJ cord-009571-mygj2nd4 1197 20 spinous spinous JJ cord-009571-mygj2nd4 1197 21 process process NN cord-009571-mygj2nd4 1198 1 ( ( -LRB- cord-009571-mygj2nd4 1198 2 8 8 CD cord-009571-mygj2nd4 1198 3 : : SYM cord-009571-mygj2nd4 1198 4 15 15 CD cord-009571-mygj2nd4 1198 5 ) ) -RRB- cord-009571-mygj2nd4 1198 6 most most RBS cord-009571-mygj2nd4 1198 7 accurately accurately RB cord-009571-mygj2nd4 1198 8 indicated indicate VBD cord-009571-mygj2nd4 1198 9 the the DT cord-009571-mygj2nd4 1198 10 diagnosis diagnosis NN cord-009571-mygj2nd4 1198 11 . . . cord-009571-mygj2nd4 1199 1 Referred refer VBN cord-009571-mygj2nd4 1199 2 abdominal abdominal JJ cord-009571-mygj2nd4 1199 3 pain pain NN cord-009571-mygj2nd4 1199 4 or or CC cord-009571-mygj2nd4 1199 5 sciatica sciatica NN cord-009571-mygj2nd4 1199 6 were be VBD cord-009571-mygj2nd4 1199 7 less less RBR cord-009571-mygj2nd4 1199 8 commonly commonly RB cord-009571-mygj2nd4 1199 9 seen see VBN cord-009571-mygj2nd4 1199 10 . . . cord-009571-mygj2nd4 1200 1 Acute acute JJ cord-009571-mygj2nd4 1200 2 paraparesis paraparesis NN cord-009571-mygj2nd4 1200 3 or or CC cord-009571-mygj2nd4 1200 4 quadaparesis quadaparesis NN cord-009571-mygj2nd4 1200 5 occurred occur VBD cord-009571-mygj2nd4 1200 6 in in IN cord-009571-mygj2nd4 1200 7 2 2 CD cord-009571-mygj2nd4 1200 8 patients patient NNS cord-009571-mygj2nd4 1200 9 with with IN cord-009571-mygj2nd4 1200 10 epidural epidural NN cord-009571-mygj2nd4 1200 11 abscess abscess NN cord-009571-mygj2nd4 1200 12 . . . cord-009571-mygj2nd4 1201 1 The the DT cord-009571-mygj2nd4 1201 2 sedimentation sedimentation NN cord-009571-mygj2nd4 1201 3 rate rate NN cord-009571-mygj2nd4 1201 4 reflected reflect VBD cord-009571-mygj2nd4 1201 5 disease disease NN cord-009571-mygj2nd4 1201 6 activity activity NN cord-009571-mygj2nd4 1201 7 in in IN cord-009571-mygj2nd4 1201 8 all all DT cord-009571-mygj2nd4 1201 9 patients patient NNS cord-009571-mygj2nd4 1201 10 . . . cord-009571-mygj2nd4 1202 1 Plain plain JJ cord-009571-mygj2nd4 1202 2 radiographs radiograph NNS cord-009571-mygj2nd4 1202 3 were be VBD cord-009571-mygj2nd4 1202 4 positive positive JJ cord-009571-mygj2nd4 1202 5 in in IN cord-009571-mygj2nd4 1202 6 only only RB cord-009571-mygj2nd4 1202 7 7 7 CD cord-009571-mygj2nd4 1202 8 patients patient NNS cord-009571-mygj2nd4 1202 9 . . . cord-009571-mygj2nd4 1203 1 Tomography tomography NN cord-009571-mygj2nd4 1203 2 was be VBD cord-009571-mygj2nd4 1203 3 helpful helpful JJ cord-009571-mygj2nd4 1203 4 in in IN cord-009571-mygj2nd4 1203 5 another another DT cord-009571-mygj2nd4 1203 6 3 3 CD cord-009571-mygj2nd4 1203 7 . . . cord-009571-mygj2nd4 1203 8 " " '' cord-009571-mygj2nd4 1204 1 " " `` cord-009571-mygj2nd4 1204 2 ' ' `` cord-009571-mygj2nd4 1204 3 Tc Tc NNP cord-009571-mygj2nd4 1204 4 pyrophosphate pyrophosphate NN cord-009571-mygj2nd4 1204 5 bone bone NN cord-009571-mygj2nd4 1204 6 scan scan NN cord-009571-mygj2nd4 1204 7 was be VBD cord-009571-mygj2nd4 1204 8 positive positive JJ cord-009571-mygj2nd4 1204 9 in in IN cord-009571-mygj2nd4 1204 10 11:12 11:12 CD cord-009571-mygj2nd4 1204 11 cases case NNS cord-009571-mygj2nd4 1204 12 and and CC cord-009571-mygj2nd4 1204 13 responsible responsible JJ cord-009571-mygj2nd4 1204 14 for for IN cord-009571-mygj2nd4 1204 15 diagnosis diagnosis NN cord-009571-mygj2nd4 1204 16 in in IN cord-009571-mygj2nd4 1204 17 4 4 CD cord-009571-mygj2nd4 1204 18 of of IN cord-009571-mygj2nd4 1204 19 5 5 CD cord-009571-mygj2nd4 1204 20 patients patient NNS cord-009571-mygj2nd4 1204 21 with with IN cord-009571-mygj2nd4 1204 22 normal normal JJ cord-009571-mygj2nd4 1204 23 radiographs radiograph NNS cord-009571-mygj2nd4 1204 24 . . . cord-009571-mygj2nd4 1205 1 Overall overall RB cord-009571-mygj2nd4 1205 2 the the DT cord-009571-mygj2nd4 1205 3 bone bone NN cord-009571-mygj2nd4 1205 4 scan scan NN cord-009571-mygj2nd4 1205 5 was be VBD cord-009571-mygj2nd4 1205 6 positive positive JJ cord-009571-mygj2nd4 1205 7 in in IN cord-009571-mygj2nd4 1205 8 11 11 CD cord-009571-mygj2nd4 1205 9 of of IN cord-009571-mygj2nd4 1205 10 12 12 CD cord-009571-mygj2nd4 1205 11 cases case NNS cord-009571-mygj2nd4 1205 12 studied study VBN cord-009571-mygj2nd4 1205 13 . . . cord-009571-mygj2nd4 1206 1 Responsible responsible JJ cord-009571-mygj2nd4 1206 2 organisms organism NNS cord-009571-mygj2nd4 1206 3 were be VBD cord-009571-mygj2nd4 1206 4 cultured culture VBN cord-009571-mygj2nd4 1206 5 usually usually RB cord-009571-mygj2nd4 1206 6 from from IN cord-009571-mygj2nd4 1206 7 the the DT cord-009571-mygj2nd4 1206 8 involved involved JJ cord-009571-mygj2nd4 1206 9 disc disc NN cord-009571-mygj2nd4 1206 10 space space NN cord-009571-mygj2nd4 1206 11 ( ( -LRB- cord-009571-mygj2nd4 1206 12 7:9 7:9 CD cord-009571-mygj2nd4 1206 13 ) ) -RRB- cord-009571-mygj2nd4 1206 14 . . . cord-009571-mygj2nd4 1207 1 Staphlococcus Staphlococcus NNP cord-009571-mygj2nd4 1207 2 aureus aureus NN cord-009571-mygj2nd4 1207 3 ( ( -LRB- cord-009571-mygj2nd4 1207 4 4 4 CD cord-009571-mygj2nd4 1207 5 ) ) -RRB- cord-009571-mygj2nd4 1207 6 and and CC cord-009571-mygj2nd4 1207 7 E. E. NNP cord-009571-mygj2nd4 1207 8 coli coli NNS cord-009571-mygj2nd4 1207 9 ( ( -LRB- cord-009571-mygj2nd4 1207 10 3 3 CD cord-009571-mygj2nd4 1207 11 ) ) -RRB- cord-009571-mygj2nd4 1207 12 were be VBD cord-009571-mygj2nd4 1207 13 the the DT cord-009571-mygj2nd4 1207 14 most most RBS cord-009571-mygj2nd4 1207 15 common common JJ cord-009571-mygj2nd4 1207 16 pathogens pathogen NNS cord-009571-mygj2nd4 1207 17 , , , cord-009571-mygj2nd4 1207 18 although although IN cord-009571-mygj2nd4 1207 19 other other JJ cord-009571-mygj2nd4 1207 20 microorganisms microorganism NNS cord-009571-mygj2nd4 1207 21 were be VBD cord-009571-mygj2nd4 1207 22 responsible responsible JJ cord-009571-mygj2nd4 1207 23 . . . cord-009571-mygj2nd4 1208 1 No no DT cord-009571-mygj2nd4 1208 2 pathogen pathogen NN cord-009571-mygj2nd4 1208 3 was be VBD cord-009571-mygj2nd4 1208 4 isolated isolate VBN cord-009571-mygj2nd4 1208 5 in in IN cord-009571-mygj2nd4 1208 6 6 6 CD cord-009571-mygj2nd4 1208 7 cases case NNS cord-009571-mygj2nd4 1208 8 . . . cord-009571-mygj2nd4 1209 1 Delay delay VB cord-009571-mygj2nd4 1209 2 in in IN cord-009571-mygj2nd4 1209 3 diagnosis diagnosis NN cord-009571-mygj2nd4 1209 4 averaged average VBD cord-009571-mygj2nd4 1209 5 14 14 CD cord-009571-mygj2nd4 1209 6 weeks week NNS cord-009571-mygj2nd4 1209 7 . . . cord-009571-mygj2nd4 1210 1 Previous previous JJ cord-009571-mygj2nd4 1210 2 spinal spinal JJ cord-009571-mygj2nd4 1210 3 roentgen roentgen NN cord-009571-mygj2nd4 1210 4 abnormalities abnormality NNS cord-009571-mygj2nd4 1210 5 ( ( -LRB- cord-009571-mygj2nd4 1210 6 9 9 CD cord-009571-mygj2nd4 1210 7 14 14 CD cord-009571-mygj2nd4 1210 8 ) ) -RRB- cord-009571-mygj2nd4 1210 9 , , , cord-009571-mygj2nd4 1210 10 disc disc NN cord-009571-mygj2nd4 1210 11 surgery surgery NN cord-009571-mygj2nd4 1210 12 ( ( -LRB- cord-009571-mygj2nd4 1210 13 3:14 3:14 CD cord-009571-mygj2nd4 1210 14 ) ) -RRB- cord-009571-mygj2nd4 1210 15 , , , cord-009571-mygj2nd4 1210 16 another another DT cord-009571-mygj2nd4 1210 17 site site NN cord-009571-mygj2nd4 1210 18 of of IN cord-009571-mygj2nd4 1210 19 active active JJ cord-009571-mygj2nd4 1210 20 infection infection NN cord-009571-mygj2nd4 1210 21 ( ( -LRB- cord-009571-mygj2nd4 1210 22 3:14 3:14 CD cord-009571-mygj2nd4 1210 23 ) ) -RRB- cord-009571-mygj2nd4 1210 24 , , , cord-009571-mygj2nd4 1210 25 and and CC cord-009571-mygj2nd4 1210 26 alcoholism alcoholism NN cord-009571-mygj2nd4 1210 27 ( ( -LRB- cord-009571-mygj2nd4 1210 28 2:14 2:14 CD cord-009571-mygj2nd4 1210 29 ) ) -RRB- cord-009571-mygj2nd4 1210 30 were be VBD cord-009571-mygj2nd4 1210 31 predisposing predispose VBG cord-009571-mygj2nd4 1210 32 factors factor NNS cord-009571-mygj2nd4 1210 33 . . . cord-009571-mygj2nd4 1211 1 Intensive intensive JJ cord-009571-mygj2nd4 1211 2 intravenous intravenous JJ cord-009571-mygj2nd4 1211 3 antibiotics antibiotic NNS cord-009571-mygj2nd4 1211 4 followed follow VBN cord-009571-mygj2nd4 1211 5 by by IN cord-009571-mygj2nd4 1211 6 two two CD cord-009571-mygj2nd4 1211 7 months month NNS cord-009571-mygj2nd4 1211 8 oral oral JJ cord-009571-mygj2nd4 1211 9 antibiotic antibiotic JJ cord-009571-mygj2nd4 1211 10 therapy therapy NN cord-009571-mygj2nd4 1211 11 proved prove VBD cord-009571-mygj2nd4 1211 12 curative curative JJ cord-009571-mygj2nd4 1211 13 . . . cord-009571-mygj2nd4 1212 1 Ten ten CD cord-009571-mygj2nd4 1212 2 of of IN cord-009571-mygj2nd4 1212 3 15 15 CD cord-009571-mygj2nd4 1212 4 patients patient NNS cord-009571-mygj2nd4 1212 5 could could MD cord-009571-mygj2nd4 1212 6 be be VB cord-009571-mygj2nd4 1212 7 followed follow VBN cord-009571-mygj2nd4 1212 8 one one CD cord-009571-mygj2nd4 1212 9 year year NN cord-009571-mygj2nd4 1212 10 after after IN cord-009571-mygj2nd4 1212 11 therapy therapy NN cord-009571-mygj2nd4 1212 12 and and CC cord-009571-mygj2nd4 1212 13 were be VBD cord-009571-mygj2nd4 1212 14 asymptomatic asymptomatic JJ cord-009571-mygj2nd4 1212 15 except except IN cord-009571-mygj2nd4 1212 16 for for IN cord-009571-mygj2nd4 1212 17 2 2 CD cord-009571-mygj2nd4 1212 18 patients patient NNS cord-009571-mygj2nd4 1212 19 with with IN cord-009571-mygj2nd4 1212 20 pre pre JJ cord-009571-mygj2nd4 1212 21 - - JJ cord-009571-mygj2nd4 1212 22 existing existing JJ cord-009571-mygj2nd4 1212 23 mecha mecha NN cord-009571-mygj2nd4 1212 24 - - HYPH cord-009571-mygj2nd4 1212 25 nial nial NNP cord-009571-mygj2nd4 1212 26 low low JJ cord-009571-mygj2nd4 1212 27 back back JJ cord-009571-mygj2nd4 1212 28 pain pain NN cord-009571-mygj2nd4 1212 29 . . . cord-009571-mygj2nd4 1213 1 None none NN cord-009571-mygj2nd4 1213 2 had have VBD cord-009571-mygj2nd4 1213 3 evidence evidence NN cord-009571-mygj2nd4 1213 4 of of IN cord-009571-mygj2nd4 1213 5 active active JJ cord-009571-mygj2nd4 1213 6 septic septic JJ cord-009571-mygj2nd4 1213 7 discitis discitis NN cord-009571-mygj2nd4 1213 8 . . . cord-009571-mygj2nd4 1214 1 One one CD cord-009571-mygj2nd4 1214 2 patient patient NN cord-009571-mygj2nd4 1214 3 died die VBD cord-009571-mygj2nd4 1214 4 of of IN cord-009571-mygj2nd4 1214 5 pulmonary pulmonary JJ cord-009571-mygj2nd4 1214 6 embolism embolism NN cord-009571-mygj2nd4 1214 7 post post NN cord-009571-mygj2nd4 1214 8 - - NN cord-009571-mygj2nd4 1214 9 discectomy discectomy NN cord-009571-mygj2nd4 1214 10 . . . cord-009571-mygj2nd4 1215 1 Epidural epidural NN cord-009571-mygj2nd4 1215 2 abscess abscess NN cord-009571-mygj2nd4 1215 3 was be VBD cord-009571-mygj2nd4 1215 4 the the DT cord-009571-mygj2nd4 1215 5 usual usual JJ cord-009571-mygj2nd4 1215 6 indication indication NN cord-009571-mygj2nd4 1215 7 for for IN cord-009571-mygj2nd4 1215 8 surgery surgery NN cord-009571-mygj2nd4 1215 9 . . . cord-009571-mygj2nd4 1216 1 The the DT cord-009571-mygj2nd4 1216 2 sedimentation sedimentation NN cord-009571-mygj2nd4 1216 3 rate rate NN cord-009571-mygj2nd4 1216 4 returned return VBD cord-009571-mygj2nd4 1216 5 to to IN cord-009571-mygj2nd4 1216 6 normal normal JJ cord-009571-mygj2nd4 1216 7 in in IN cord-009571-mygj2nd4 1216 8 all all DT cord-009571-mygj2nd4 1216 9 survivors survivor NNS cord-009571-mygj2nd4 1216 10 . . . cord-009571-mygj2nd4 1217 1 Septic septic JJ cord-009571-mygj2nd4 1217 2 discitis discitis NNP cord-009571-mygj2nd4 1217 3 is be VBZ cord-009571-mygj2nd4 1217 4 a a DT cord-009571-mygj2nd4 1217 5 common common JJ cord-009571-mygj2nd4 1217 6 disease disease NN cord-009571-mygj2nd4 1217 7 , , , cord-009571-mygj2nd4 1217 8 but but CC cord-009571-mygj2nd4 1217 9 delay delay VB cord-009571-mygj2nd4 1217 10 in in IN cord-009571-mygj2nd4 1217 11 diagnosis diagnosis NN cord-009571-mygj2nd4 1217 12 is be VBZ cord-009571-mygj2nd4 1217 13 usual usual JJ cord-009571-mygj2nd4 1217 14 despite despite IN cord-009571-mygj2nd4 1217 15 a a DT cord-009571-mygj2nd4 1217 16 characteristic characteristic JJ cord-009571-mygj2nd4 1217 17 clinical clinical JJ cord-009571-mygj2nd4 1217 18 syndrome syndrome NN cord-009571-mygj2nd4 1217 19 . . . cord-009571-mygj2nd4 1218 1 The the DT cord-009571-mygj2nd4 1218 2 sedimentation sedimentation NN cord-009571-mygj2nd4 1218 3 rate rate NN cord-009571-mygj2nd4 1218 4 and and CC cord-009571-mygj2nd4 1218 5 bone bone NN cord-009571-mygj2nd4 1218 6 scan scan NN cord-009571-mygj2nd4 1218 7 are be VBP cord-009571-mygj2nd4 1218 8 the the DT cord-009571-mygj2nd4 1218 9 most most RBS cord-009571-mygj2nd4 1218 10 useful useful JJ cord-009571-mygj2nd4 1218 11 adjuncts adjunct NNS cord-009571-mygj2nd4 1218 12 to to IN cord-009571-mygj2nd4 1218 13 diagnosis diagnosis NN cord-009571-mygj2nd4 1218 14 . . . cord-009571-mygj2nd4 1219 1 Aspiration aspiration NN cord-009571-mygj2nd4 1219 2 of of IN cord-009571-mygj2nd4 1219 3 the the DT cord-009571-mygj2nd4 1219 4 suspected suspect VBN cord-009571-mygj2nd4 1219 5 disc disc NN cord-009571-mygj2nd4 1219 6 space space NN cord-009571-mygj2nd4 1219 7 for for IN cord-009571-mygj2nd4 1219 8 responsible responsible JJ cord-009571-mygj2nd4 1219 9 organisms organism NNS cord-009571-mygj2nd4 1219 10 is be VBZ cord-009571-mygj2nd4 1219 11 advocated advocate VBN cord-009571-mygj2nd4 1219 12 . . . cord-009571-mygj2nd4 1220 1 Most Most JJS cord-009571-mygj2nd4 1220 2 patients patient NNS cord-009571-mygj2nd4 1220 3 are be VBP cord-009571-mygj2nd4 1220 4 afforded afford VBN cord-009571-mygj2nd4 1220 5 excellent excellent JJ cord-009571-mygj2nd4 1220 6 prognosis prognosis NN cord-009571-mygj2nd4 1220 7 following follow VBG cord-009571-mygj2nd4 1220 8 judicious judicious JJ cord-009571-mygj2nd4 1220 9 rest rest NN cord-009571-mygj2nd4 1220 10 and and CC cord-009571-mygj2nd4 1220 11 prolonged prolong VBD cord-009571-mygj2nd4 1220 12 antibiotic antibiotic JJ cord-009571-mygj2nd4 1220 13 administration administration NN cord-009571-mygj2nd4 1220 14 . . . cord-009571-mygj2nd4 1221 1 Musculoskeletal musculoskeletal JJ cord-009571-mygj2nd4 1221 2 complaints complaint NNS cord-009571-mygj2nd4 1221 3 of of IN cord-009571-mygj2nd4 1221 4 uncertain uncertain JJ cord-009571-mygj2nd4 1221 5 etiology etiology NN cord-009571-mygj2nd4 1221 6 have have VBP cord-009571-mygj2nd4 1221 7 been be VBN cord-009571-mygj2nd4 1221 8 noted note VBN cord-009571-mygj2nd4 1221 9 in in IN cord-009571-mygj2nd4 1221 10 up up IN cord-009571-mygj2nd4 1221 11 to to TO cord-009571-mygj2nd4 1221 12 30 30 CD cord-009571-mygj2nd4 1221 13 % % NN cord-009571-mygj2nd4 1221 14 of of IN cord-009571-mygj2nd4 1221 15 patients patient NNS cord-009571-mygj2nd4 1221 16 receiving receive VBG cord-009571-mygj2nd4 1221 17 a a DT cord-009571-mygj2nd4 1221 18 kidney kidney NN cord-009571-mygj2nd4 1221 19 transplant transplant NN cord-009571-mygj2nd4 1221 20 . . . cord-009571-mygj2nd4 1222 1 We -PRON- PRP cord-009571-mygj2nd4 1222 2 have have VBP cord-009571-mygj2nd4 1222 3 studied study VBN cord-009571-mygj2nd4 1222 4 prospectively prospectively RB cord-009571-mygj2nd4 1222 5 35 35 CD cord-009571-mygj2nd4 1222 6 consecutive consecutive JJ cord-009571-mygj2nd4 1222 7 renal renal JJ cord-009571-mygj2nd4 1222 8 transplant transplant NN cord-009571-mygj2nd4 1222 9 recipients recipient NNS cord-009571-mygj2nd4 1222 10 . . . cord-009571-mygj2nd4 1223 1 Joint joint JJ cord-009571-mygj2nd4 1223 2 pain pain NN cord-009571-mygj2nd4 1223 3 , , , cord-009571-mygj2nd4 1223 4 stiffness stiffness NN cord-009571-mygj2nd4 1223 5 , , , cord-009571-mygj2nd4 1223 6 and and CC cord-009571-mygj2nd4 1223 7 swelling swelling NN cord-009571-mygj2nd4 1223 8 were be VBD cord-009571-mygj2nd4 1223 9 assessed assess VBN cord-009571-mygj2nd4 1223 10 5 5 CD cord-009571-mygj2nd4 1223 11 - - SYM cord-009571-mygj2nd4 1223 12 6 6 CD cord-009571-mygj2nd4 1223 13 days day NNS cord-009571-mygj2nd4 1223 14 in in IN cord-009571-mygj2nd4 1223 15 every every DT cord-009571-mygj2nd4 1223 16 week week NN cord-009571-mygj2nd4 1223 17 of of IN cord-009571-mygj2nd4 1223 18 the the DT cord-009571-mygj2nd4 1223 19 postoperative postoperative JJ cord-009571-mygj2nd4 1223 20 period period NN cord-009571-mygj2nd4 1223 21 . . . cord-009571-mygj2nd4 1224 1 Six six CD cord-009571-mygj2nd4 1224 2 patients patient NNS cord-009571-mygj2nd4 1224 3 experienced experience VBD cord-009571-mygj2nd4 1224 4 joint joint JJ cord-009571-mygj2nd4 1224 5 pain pain NN cord-009571-mygj2nd4 1224 6 affecting affect VBG cord-009571-mygj2nd4 1224 7 chiefly chiefly RB cord-009571-mygj2nd4 1224 8 knees knee NNS cord-009571-mygj2nd4 1224 9 but but CC cord-009571-mygj2nd4 1224 10 also also RB cord-009571-mygj2nd4 1224 11 shoulder shoulder NN cord-009571-mygj2nd4 1224 12 , , , cord-009571-mygj2nd4 1224 13 ankle ankle NN cord-009571-mygj2nd4 1224 14 , , , cord-009571-mygj2nd4 1224 15 and and CC cord-009571-mygj2nd4 1224 16 temporomandibular temporomandibular NN cord-009571-mygj2nd4 1224 17 joints joint NNS cord-009571-mygj2nd4 1224 18 . . . cord-009571-mygj2nd4 1225 1 Arthralgias Arthralgias NNP cord-009571-mygj2nd4 1225 2 were be VBD cord-009571-mygj2nd4 1225 3 variable variable JJ cord-009571-mygj2nd4 1225 4 in in IN cord-009571-mygj2nd4 1225 5 severity severity NN cord-009571-mygj2nd4 1225 6 and and CC cord-009571-mygj2nd4 1225 7 duration duration NN cord-009571-mygj2nd4 1225 8 , , , cord-009571-mygj2nd4 1225 9 and and CC cord-009571-mygj2nd4 1225 10 in in IN cord-009571-mygj2nd4 1225 11 time time NN cord-009571-mygj2nd4 1225 12 of of IN cord-009571-mygj2nd4 1225 13 onset onset NN cord-009571-mygj2nd4 1225 14 after after IN cord-009571-mygj2nd4 1225 15 transplantation transplantation NN cord-009571-mygj2nd4 1225 16 . . . cord-009571-mygj2nd4 1226 1 In in IN cord-009571-mygj2nd4 1226 2 2 2 CD cord-009571-mygj2nd4 1226 3 patients patient NNS cord-009571-mygj2nd4 1226 4 pain pain NN cord-009571-mygj2nd4 1226 5 coincided coincide VBN cord-009571-mygj2nd4 1226 6 with with IN cord-009571-mygj2nd4 1226 7 reduction reduction NN cord-009571-mygj2nd4 1226 8 of of IN cord-009571-mygj2nd4 1226 9 steroid steroid NN cord-009571-mygj2nd4 1226 10 dosage dosage NN cord-009571-mygj2nd4 1226 11 and and CC cord-009571-mygj2nd4 1226 12 was be VBD cord-009571-mygj2nd4 1226 13 abolished abolish VBN cord-009571-mygj2nd4 1226 14 by by IN cord-009571-mygj2nd4 1226 15 modifying modify VBG cord-009571-mygj2nd4 1226 16 the the DT cord-009571-mygj2nd4 1226 17 treatment treatment NN cord-009571-mygj2nd4 1226 18 regimen regimen NN cord-009571-mygj2nd4 1226 19 . . . cord-009571-mygj2nd4 1227 1 A a DT cord-009571-mygj2nd4 1227 2 third third JJ cord-009571-mygj2nd4 1227 3 patient patient NN cord-009571-mygj2nd4 1227 4 , , , cord-009571-mygj2nd4 1227 5 who who WP cord-009571-mygj2nd4 1227 6 developed develop VBD cord-009571-mygj2nd4 1227 7 transient transient JJ cord-009571-mygj2nd4 1227 8 joint joint JJ cord-009571-mygj2nd4 1227 9 pain pain NN cord-009571-mygj2nd4 1227 10 17 17 CD cord-009571-mygj2nd4 1227 11 days day NNS cord-009571-mygj2nd4 1227 12 after after IN cord-009571-mygj2nd4 1227 13 appearance appearance NN cord-009571-mygj2nd4 1227 14 of of IN cord-009571-mygj2nd4 1227 15 a a DT cord-009571-mygj2nd4 1227 16 painless painless JJ cord-009571-mygj2nd4 1227 17 effusion effusion NN cord-009571-mygj2nd4 1227 18 , , , cord-009571-mygj2nd4 1227 19 had have VBD cord-009571-mygj2nd4 1227 20 hyperparathyroidism hyperparathyroidism NN cord-009571-mygj2nd4 1227 21 . . . cord-009571-mygj2nd4 1228 1 Joint joint JJ cord-009571-mygj2nd4 1228 2 effusions effusion NNS cord-009571-mygj2nd4 1228 3 , , , cord-009571-mygj2nd4 1228 4 confirmed confirm VBN cord-009571-mygj2nd4 1228 5 by by IN cord-009571-mygj2nd4 1228 6 arthrocentesis arthrocentesis NNP cord-009571-mygj2nd4 1228 7 , , , cord-009571-mygj2nd4 1228 8 appeared appear VBD cord-009571-mygj2nd4 1228 9 in in IN cord-009571-mygj2nd4 1228 10 18 18 CD cord-009571-mygj2nd4 1228 11 knees knee NNS cord-009571-mygj2nd4 1228 12 of of IN cord-009571-mygj2nd4 1228 13 11 11 CD cord-009571-mygj2nd4 1228 14 patients patient NNS cord-009571-mygj2nd4 1228 15 . . . cord-009571-mygj2nd4 1229 1 Mean mean JJ cord-009571-mygj2nd4 1229 2 duration duration NN cord-009571-mygj2nd4 1229 3 from from IN cord-009571-mygj2nd4 1229 4 transplantation transplantation NN cord-009571-mygj2nd4 1229 5 to to IN cord-009571-mygj2nd4 1229 6 first first JJ cord-009571-mygj2nd4 1229 7 joint joint JJ cord-009571-mygj2nd4 1229 8 aspiration aspiration NN cord-009571-mygj2nd4 1229 9 was be VBD cord-009571-mygj2nd4 1229 10 17 17 CD cord-009571-mygj2nd4 1229 11 days day NNS cord-009571-mygj2nd4 1229 12 . . . cord-009571-mygj2nd4 1230 1 Effusions effusion NNS cord-009571-mygj2nd4 1230 2 were be VBD cord-009571-mygj2nd4 1230 3 generally generally RB cord-009571-mygj2nd4 1230 4 unaccompanied unaccompanied JJ cord-009571-mygj2nd4 1230 5 by by IN cord-009571-mygj2nd4 1230 6 pain pain NN cord-009571-mygj2nd4 1230 7 , , , cord-009571-mygj2nd4 1230 8 except except IN cord-009571-mygj2nd4 1230 9 on on IN cord-009571-mygj2nd4 1230 10 extreme extreme JJ cord-009571-mygj2nd4 1230 11 flexion flexion NN cord-009571-mygj2nd4 1230 12 , , , cord-009571-mygj2nd4 1230 13 and and CC cord-009571-mygj2nd4 1230 14 persisted persist VBD cord-009571-mygj2nd4 1230 15 for for IN cord-009571-mygj2nd4 1230 16 24 24 CD cord-009571-mygj2nd4 1230 17 hours hour NNS cord-009571-mygj2nd4 1230 18 to to IN cord-009571-mygj2nd4 1230 19 6 6 CD cord-009571-mygj2nd4 1230 20 weeks week NNS cord-009571-mygj2nd4 1230 21 . . . cord-009571-mygj2nd4 1231 1 Twenty twenty CD cord-009571-mygj2nd4 1231 2 - - HYPH cord-009571-mygj2nd4 1231 3 five five CD cord-009571-mygj2nd4 1231 4 synovial synovial JJ cord-009571-mygj2nd4 1231 5 fluid fluid NN cord-009571-mygj2nd4 1231 6 samples sample NNS cord-009571-mygj2nd4 1231 7 were be VBD cord-009571-mygj2nd4 1231 8 obtained obtain VBN cord-009571-mygj2nd4 1231 9 from from IN cord-009571-mygj2nd4 1231 10 the the DT cord-009571-mygj2nd4 1231 11 18 18 CD cord-009571-mygj2nd4 1231 12 knees knee NNS cord-009571-mygj2nd4 1231 13 . . . cord-009571-mygj2nd4 1232 1 The the DT cord-009571-mygj2nd4 1232 2 mean mean JJ cord-009571-mygj2nd4 1232 3 synovial synovial JJ cord-009571-mygj2nd4 1232 4 fluid fluid NN cord-009571-mygj2nd4 1232 5 volume volume NN cord-009571-mygj2nd4 1232 6 was be VBD cord-009571-mygj2nd4 1232 7 15 15 CD cord-009571-mygj2nd4 1232 8 ml ml NN cord-009571-mygj2nd4 1232 9 ( ( -LRB- cord-009571-mygj2nd4 1232 10 range range NN cord-009571-mygj2nd4 1232 11 , , , cord-009571-mygj2nd4 1232 12 3 3 CD cord-009571-mygj2nd4 1232 13 - - SYM cord-009571-mygj2nd4 1232 14 65 65 CD cord-009571-mygj2nd4 1232 15 ml ml NN cord-009571-mygj2nd4 1232 16 ) ) -RRB- cord-009571-mygj2nd4 1232 17 and and CC cord-009571-mygj2nd4 1232 18 the the DT cord-009571-mygj2nd4 1232 19 mean mean JJ cord-009571-mygj2nd4 1232 20 cell cell NN cord-009571-mygj2nd4 1232 21 count count NN cord-009571-mygj2nd4 1232 22 was be VBD cord-009571-mygj2nd4 1232 23 28 28 CD cord-009571-mygj2nd4 1232 24 / / SYM cord-009571-mygj2nd4 1232 25 mma mma NNP cord-009571-mygj2nd4 1232 26 ( ( -LRB- cord-009571-mygj2nd4 1232 27 range range NNP cord-009571-mygj2nd4 1232 28 0 0 CD cord-009571-mygj2nd4 1232 29 - - HYPH cord-009571-mygj2nd4 1232 30 150 150 CD cord-009571-mygj2nd4 1232 31 / / SYM cord-009571-mygj2nd4 1232 32 mms mms NN cord-009571-mygj2nd4 1232 33 ) ) -RRB- cord-009571-mygj2nd4 1232 34 . . . cord-009571-mygj2nd4 1233 1 In in IN cord-009571-mygj2nd4 1233 2 every every DT cord-009571-mygj2nd4 1233 3 case case NN cord-009571-mygj2nd4 1233 4 viscosity viscosity NN cord-009571-mygj2nd4 1233 5 and and CC cord-009571-mygj2nd4 1233 6 mucin mucin NN cord-009571-mygj2nd4 1233 7 test test NN cord-009571-mygj2nd4 1233 8 were be VBD cord-009571-mygj2nd4 1233 9 normal normal JJ cord-009571-mygj2nd4 1233 10 and and CC cord-009571-mygj2nd4 1233 11 crystals crystal NNS cord-009571-mygj2nd4 1233 12 were be VBD cord-009571-mygj2nd4 1233 13 not not RB cord-009571-mygj2nd4 1233 14 found find VBN cord-009571-mygj2nd4 1233 15 on on IN cord-009571-mygj2nd4 1233 16 polarization polarization NN cord-009571-mygj2nd4 1233 17 microscopy microscopy NN cord-009571-mygj2nd4 1233 18 of of IN cord-009571-mygj2nd4 1233 19 the the DT cord-009571-mygj2nd4 1233 20 centrifuged centrifuge VBN cord-009571-mygj2nd4 1233 21 fluids fluid NNS cord-009571-mygj2nd4 1233 22 . . . cord-009571-mygj2nd4 1234 1 Joint joint JJ cord-009571-mygj2nd4 1234 2 x x NNS cord-009571-mygj2nd4 1234 3 - - NNS cord-009571-mygj2nd4 1234 4 rays ray NNS cord-009571-mygj2nd4 1234 5 showed show VBD cord-009571-mygj2nd4 1234 6 only only RB cord-009571-mygj2nd4 1234 7 soft soft JJ cord-009571-mygj2nd4 1234 8 tissue tissue NN cord-009571-mygj2nd4 1234 9 swelling swelling NN cord-009571-mygj2nd4 1234 10 . . . cord-009571-mygj2nd4 1235 1 Electron electron NN cord-009571-mygj2nd4 1235 2 microscopy microscopy NN cord-009571-mygj2nd4 1235 3 of of IN cord-009571-mygj2nd4 1235 4 three three CD cord-009571-mygj2nd4 1235 5 fluids fluid NNS cord-009571-mygj2nd4 1235 6 revealed reveal VBN cord-009571-mygj2nd4 1235 7 no no DT cord-009571-mygj2nd4 1235 8 hydroxyapatite hydroxyapatite JJ cord-009571-mygj2nd4 1235 9 - - HYPH cord-009571-mygj2nd4 1235 10 like like JJ cord-009571-mygj2nd4 1235 11 material material NN cord-009571-mygj2nd4 1235 12 . . . cord-009571-mygj2nd4 1236 1 Synovial synovial JJ cord-009571-mygj2nd4 1236 2 biopsies biopsy NNS cord-009571-mygj2nd4 1236 3 in in IN cord-009571-mygj2nd4 1236 4 2 2 CD cord-009571-mygj2nd4 1236 5 patients patient NNS cord-009571-mygj2nd4 1236 6 were be VBD cord-009571-mygj2nd4 1236 7 normal normal JJ cord-009571-mygj2nd4 1236 8 by by IN cord-009571-mygj2nd4 1236 9 light light JJ cord-009571-mygj2nd4 1236 10 microscopy microscopy NNS cord-009571-mygj2nd4 1236 11 . . . cord-009571-mygj2nd4 1237 1 No no DT cord-009571-mygj2nd4 1237 2 cases case NNS cord-009571-mygj2nd4 1237 3 of of IN cord-009571-mygj2nd4 1237 4 aseptic aseptic JJ cord-009571-mygj2nd4 1237 5 necrosis necrosis NN cord-009571-mygj2nd4 1237 6 have have VBP cord-009571-mygj2nd4 1237 7 been be VBN cord-009571-mygj2nd4 1237 8 identified identify VBN cord-009571-mygj2nd4 1237 9 . . . cord-009571-mygj2nd4 1238 1 Tests test NNS cord-009571-mygj2nd4 1238 2 for for IN cord-009571-mygj2nd4 1238 3 serum serum NN cord-009571-mygj2nd4 1238 4 ANA ANA NNP cord-009571-mygj2nd4 1238 5 , , , cord-009571-mygj2nd4 1238 6 immune immune JJ cord-009571-mygj2nd4 1238 7 complexes complex NNS cord-009571-mygj2nd4 1238 8 , , , cord-009571-mygj2nd4 1238 9 and and CC cord-009571-mygj2nd4 1238 10 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1238 11 factors factor NNS cord-009571-mygj2nd4 1238 12 were be VBD cord-009571-mygj2nd4 1238 13 all all DT cord-009571-mygj2nd4 1238 14 negative negative JJ cord-009571-mygj2nd4 1238 15 . . . cord-009571-mygj2nd4 1239 1 Neither neither CC cord-009571-mygj2nd4 1239 2 the the DT cord-009571-mygj2nd4 1239 3 arthralgias arthralgias JJ cord-009571-mygj2nd4 1239 4 nor nor CC cord-009571-mygj2nd4 1239 5 effusions effusion NNS cord-009571-mygj2nd4 1239 6 bore bear VBD cord-009571-mygj2nd4 1239 7 any any DT cord-009571-mygj2nd4 1239 8 apparent apparent JJ cord-009571-mygj2nd4 1239 9 relationship relationship NN cord-009571-mygj2nd4 1239 10 to to IN cord-009571-mygj2nd4 1239 11 the the DT cord-009571-mygj2nd4 1239 12 source source NN cord-009571-mygj2nd4 1239 13 of of IN cord-009571-mygj2nd4 1239 14 the the DT cord-009571-mygj2nd4 1239 15 donor donor NN cord-009571-mygj2nd4 1239 16 kidney kidney NN cord-009571-mygj2nd4 1239 17 , , , cord-009571-mygj2nd4 1239 18 renal renal JJ cord-009571-mygj2nd4 1239 19 function function NN cord-009571-mygj2nd4 1239 20 , , , cord-009571-mygj2nd4 1239 21 fever fever NN cord-009571-mygj2nd4 1239 22 , , , cord-009571-mygj2nd4 1239 23 or or CC cord-009571-mygj2nd4 1239 24 use use NN cord-009571-mygj2nd4 1239 25 of of IN cord-009571-mygj2nd4 1239 26 anti anti JJ cord-009571-mygj2nd4 1239 27 - - JJ cord-009571-mygj2nd4 1239 28 thymocyte thymocyte JJ cord-009571-mygj2nd4 1239 29 globulin globulin NN cord-009571-mygj2nd4 1239 30 . . . cord-009571-mygj2nd4 1240 1 No no DT cord-009571-mygj2nd4 1240 2 major major JJ cord-009571-mygj2nd4 1240 3 transplant transplant NN cord-009571-mygj2nd4 1240 4 rejection rejection NN cord-009571-mygj2nd4 1240 5 episodes episode NNS cord-009571-mygj2nd4 1240 6 occurred occur VBD cord-009571-mygj2nd4 1240 7 in in IN cord-009571-mygj2nd4 1240 8 any any DT cord-009571-mygj2nd4 1240 9 of of IN cord-009571-mygj2nd4 1240 10 the the DT cord-009571-mygj2nd4 1240 11 patients patient NNS cord-009571-mygj2nd4 1240 12 with with IN cord-009571-mygj2nd4 1240 13 effusions effusion NNS cord-009571-mygj2nd4 1240 14 or or CC cord-009571-mygj2nd4 1240 15 arthralgias arthralgias JJ cord-009571-mygj2nd4 1240 16 , , , cord-009571-mygj2nd4 1240 17 whereas whereas IN cord-009571-mygj2nd4 1240 18 no no DT cord-009571-mygj2nd4 1240 19 joint joint JJ cord-009571-mygj2nd4 1240 20 problems problem NNS cord-009571-mygj2nd4 1240 21 arose arise VBD cord-009571-mygj2nd4 1240 22 in in IN cord-009571-mygj2nd4 1240 23 any any DT cord-009571-mygj2nd4 1240 24 of of IN cord-009571-mygj2nd4 1240 25 9 9 CD cord-009571-mygj2nd4 1240 26 patients patient NNS cord-009571-mygj2nd4 1240 27 who who WP cord-009571-mygj2nd4 1240 28 rejected reject VBD cord-009571-mygj2nd4 1240 29 donor donor NN cord-009571-mygj2nd4 1240 30 kidneys kidney NNS cord-009571-mygj2nd4 1240 31 in in IN cord-009571-mygj2nd4 1240 32 the the DT cord-009571-mygj2nd4 1240 33 postoperative postoperative JJ cord-009571-mygj2nd4 1240 34 period period NN cord-009571-mygj2nd4 1240 35 . . . cord-009571-mygj2nd4 1241 1 Thus thus RB cord-009571-mygj2nd4 1241 2 , , , cord-009571-mygj2nd4 1241 3 benign benign JJ cord-009571-mygj2nd4 1241 4 effusions effusion NNS cord-009571-mygj2nd4 1241 5 are be VBP cord-009571-mygj2nd4 1241 6 common common JJ cord-009571-mygj2nd4 1241 7 after after IN cord-009571-mygj2nd4 1241 8 renal renal JJ cord-009571-mygj2nd4 1241 9 transplantation transplantation NN cord-009571-mygj2nd4 1241 10 . . . cord-009571-mygj2nd4 1242 1 They -PRON- PRP cord-009571-mygj2nd4 1242 2 appear appear VBP cord-009571-mygj2nd4 1242 3 unrelated unrelated JJ cord-009571-mygj2nd4 1242 4 to to IN cord-009571-mygj2nd4 1242 5 immunologic immunologic JJ cord-009571-mygj2nd4 1242 6 factors factor NNS cord-009571-mygj2nd4 1242 7 or or CC cord-009571-mygj2nd4 1242 8 crystal crystal NN cord-009571-mygj2nd4 1242 9 deposition deposition NN cord-009571-mygj2nd4 1242 10 and and CC cord-009571-mygj2nd4 1242 11 may may MD cord-009571-mygj2nd4 1242 12 be be VB cord-009571-mygj2nd4 1242 13 due due JJ cord-009571-mygj2nd4 1242 14 to to IN cord-009571-mygj2nd4 1242 15 transudation transudation NN cord-009571-mygj2nd4 1242 16 associated associate VBN cord-009571-mygj2nd4 1242 17 with with IN cord-009571-mygj2nd4 1242 18 high high JJ cord-009571-mygj2nd4 1242 19 - - HYPH cord-009571-mygj2nd4 1242 20 dose dose NN cord-009571-mygj2nd4 1242 21 steroid steroid NN cord-009571-mygj2nd4 1242 22 treatment treatment NN cord-009571-mygj2nd4 1242 23 . . . cord-009571-mygj2nd4 1243 1 To to TO cord-009571-mygj2nd4 1243 2 investigate investigate VB cord-009571-mygj2nd4 1243 3 the the DT cord-009571-mygj2nd4 1243 4 hypothesis hypothesis NN cord-009571-mygj2nd4 1243 5 that that IN cord-009571-mygj2nd4 1243 6 infection infection NN cord-009571-mygj2nd4 1243 7 may may MD cord-009571-mygj2nd4 1243 8 precipitate precipitate VB cord-009571-mygj2nd4 1243 9 certain certain JJ cord-009571-mygj2nd4 1243 10 arthritis arthritis NN cord-009571-mygj2nd4 1243 11 syndromes syndrome NNS cord-009571-mygj2nd4 1243 12 , , , cord-009571-mygj2nd4 1243 13 we -PRON- PRP cord-009571-mygj2nd4 1243 14 performed perform VBD cord-009571-mygj2nd4 1243 15 a a DT cord-009571-mygj2nd4 1243 16 battery battery NN cord-009571-mygj2nd4 1243 17 of of IN cord-009571-mygj2nd4 1243 18 infectious infectious JJ cord-009571-mygj2nd4 1243 19 agent agent NN cord-009571-mygj2nd4 1243 20 serologic serologic NNP cord-009571-mygj2nd4 1243 21 titrations titration NNS cord-009571-mygj2nd4 1243 22 on on IN cord-009571-mygj2nd4 1243 23 130 130 CD cord-009571-mygj2nd4 1243 24 early early RB cord-009571-mygj2nd4 1243 25 - - HYPH cord-009571-mygj2nd4 1243 26 diagnosed diagnose VBN cord-009571-mygj2nd4 1243 27 arthritis arthritis NN cord-009571-mygj2nd4 1243 28 patients patient NNS cord-009571-mygj2nd4 1243 29 and and CC cord-009571-mygj2nd4 1243 30 60 60 CD cord-009571-mygj2nd4 1243 31 normal normal JJ cord-009571-mygj2nd4 1243 32 controls control NNS cord-009571-mygj2nd4 1243 33 . . . cord-009571-mygj2nd4 1244 1 Forty forty CD cord-009571-mygj2nd4 1244 2 - - HYPH cord-009571-mygj2nd4 1244 3 five five CD cord-009571-mygj2nd4 1244 4 antigens antigen NNS cord-009571-mygj2nd4 1244 5 were be VBD cord-009571-mygj2nd4 1244 6 employed employ VBN cord-009571-mygj2nd4 1244 7 : : : cord-009571-mygj2nd4 1244 8 8 8 CD cord-009571-mygj2nd4 1244 9 for for IN cord-009571-mygj2nd4 1244 10 common common JJ cord-009571-mygj2nd4 1244 11 bacteria bacteria NNS cord-009571-mygj2nd4 1244 12 , , , cord-009571-mygj2nd4 1244 13 6 6 CD cord-009571-mygj2nd4 1244 14 for for IN cord-009571-mygj2nd4 1244 15 mycoplasma mycoplasma NN cord-009571-mygj2nd4 1244 16 , , , cord-009571-mygj2nd4 1244 17 9 9 CD cord-009571-mygj2nd4 1244 18 for for IN cord-009571-mygj2nd4 1244 19 respiratory respiratory JJ cord-009571-mygj2nd4 1244 20 viruses virus NNS cord-009571-mygj2nd4 1244 21 , , , cord-009571-mygj2nd4 1244 22 5 5 CD cord-009571-mygj2nd4 1244 23 for for IN cord-009571-mygj2nd4 1244 24 other other JJ cord-009571-mygj2nd4 1244 25 viruses virus NNS cord-009571-mygj2nd4 1244 26 , , , cord-009571-mygj2nd4 1244 27 and and CC cord-009571-mygj2nd4 1244 28 17 17 CD cord-009571-mygj2nd4 1244 29 for for IN cord-009571-mygj2nd4 1244 30 Y Y NNP cord-009571-mygj2nd4 1244 31 enterocolitica enterocolitica NNP cord-009571-mygj2nd4 1244 32 . . . cord-009571-mygj2nd4 1245 1 The the DT cord-009571-mygj2nd4 1245 2 arthritis arthritis NN cord-009571-mygj2nd4 1245 3 patients patient NNS cord-009571-mygj2nd4 1245 4 included include VBD cord-009571-mygj2nd4 1245 5 25 25 CD cord-009571-mygj2nd4 1245 6 with with IN cord-009571-mygj2nd4 1245 7 SLE SLE NNP cord-009571-mygj2nd4 1245 8 , , , cord-009571-mygj2nd4 1245 9 48 48 CD cord-009571-mygj2nd4 1245 10 with with IN cord-009571-mygj2nd4 1245 11 RA RA NNP cord-009571-mygj2nd4 1245 12 , , , cord-009571-mygj2nd4 1245 13 14 14 CD cord-009571-mygj2nd4 1245 14 with with IN cord-009571-mygj2nd4 1245 15 JRA JRA NNP cord-009571-mygj2nd4 1245 16 , , , cord-009571-mygj2nd4 1245 17 and and CC cord-009571-mygj2nd4 1245 18 43 43 CD cord-009571-mygj2nd4 1245 19 with with IN cord-009571-mygj2nd4 1245 20 arthritis arthritis NN cord-009571-mygj2nd4 1245 21 of of IN cord-009571-mygj2nd4 1245 22 undetermined undetermined JJ cord-009571-mygj2nd4 1245 23 diagnosis diagnosis NN cord-009571-mygj2nd4 1245 24 ( ( -LRB- cord-009571-mygj2nd4 1245 25 AUD AUD NNP cord-009571-mygj2nd4 1245 26 ) ) -RRB- cord-009571-mygj2nd4 1245 27 . . . cord-009571-mygj2nd4 1246 1 Data datum NNS cord-009571-mygj2nd4 1246 2 were be VBD cord-009571-mygj2nd4 1246 3 analyzed analyze VBN cord-009571-mygj2nd4 1246 4 by by IN cord-009571-mygj2nd4 1246 5 diagnostic diagnostic JJ cord-009571-mygj2nd4 1246 6 groups group NNS cord-009571-mygj2nd4 1246 7 and and CC cord-009571-mygj2nd4 1246 8 B27 B27 NNP cord-009571-mygj2nd4 1246 9 status status NN cord-009571-mygj2nd4 1246 10 . . . cord-009571-mygj2nd4 1247 1 No no DT cord-009571-mygj2nd4 1247 2 significant significant JJ cord-009571-mygj2nd4 1247 3 difference difference NN cord-009571-mygj2nd4 1247 4 was be VBD cord-009571-mygj2nd4 1247 5 found find VBN cord-009571-mygj2nd4 1247 6 among among IN cord-009571-mygj2nd4 1247 7 the the DT cord-009571-mygj2nd4 1247 8 arthritis arthritis NN cord-009571-mygj2nd4 1247 9 and and CC cord-009571-mygj2nd4 1247 10 control control NN cord-009571-mygj2nd4 1247 11 groups group NNS cord-009571-mygj2nd4 1247 12 in in IN cord-009571-mygj2nd4 1247 13 antibody antibody NN cord-009571-mygj2nd4 1247 14 titers titer NNS cord-009571-mygj2nd4 1247 15 to to IN cord-009571-mygj2nd4 1247 16 any any DT cord-009571-mygj2nd4 1247 17 of of IN cord-009571-mygj2nd4 1247 18 the the DT cord-009571-mygj2nd4 1247 19 common common JJ cord-009571-mygj2nd4 1247 20 bacterial bacterial JJ cord-009571-mygj2nd4 1247 21 antigens antigen NNS cord-009571-mygj2nd4 1247 22 or or CC cord-009571-mygj2nd4 1247 23 the the DT cord-009571-mygj2nd4 1247 24 mycoplasma mycoplasma NN cord-009571-mygj2nd4 1247 25 species specie NNS cord-009571-mygj2nd4 1247 26 , , , cord-009571-mygj2nd4 1247 27 8 8 CD cord-009571-mygj2nd4 1247 28 of of IN cord-009571-mygj2nd4 1247 29 the the DT cord-009571-mygj2nd4 1247 30 respi respi JJ cord-009571-mygj2nd4 1247 31 - - HYPH cord-009571-mygj2nd4 1247 32 ratory ratory NNP cord-009571-mygj2nd4 1247 33 viruses virus NNS cord-009571-mygj2nd4 1247 34 , , , cord-009571-mygj2nd4 1247 35 and and CC cord-009571-mygj2nd4 1247 36 2 2 CD cord-009571-mygj2nd4 1247 37 of of IN cord-009571-mygj2nd4 1247 38 the the DT cord-009571-mygj2nd4 1247 39 other other JJ cord-009571-mygj2nd4 1247 40 viruses virus NNS cord-009571-mygj2nd4 1247 41 . . . cord-009571-mygj2nd4 1248 1 In in IN cord-009571-mygj2nd4 1248 2 JRA JRA NNP cord-009571-mygj2nd4 1248 3 patients patient NNS cord-009571-mygj2nd4 1248 4 , , , cord-009571-mygj2nd4 1248 5 adenovirus adenovirus NN cord-009571-mygj2nd4 1248 6 ( ( -LRB- cord-009571-mygj2nd4 1248 7 group group NN cord-009571-mygj2nd4 1248 8 ) ) -RRB- cord-009571-mygj2nd4 1248 9 and and CC cord-009571-mygj2nd4 1248 10 herpes herpes NN cord-009571-mygj2nd4 1248 11 simplex simplex NN cord-009571-mygj2nd4 1248 12 ( ( -LRB- cord-009571-mygj2nd4 1248 13 types type NNS cord-009571-mygj2nd4 1248 14 1 1 CD cord-009571-mygj2nd4 1248 15 and and CC cord-009571-mygj2nd4 1248 16 2 2 CD cord-009571-mygj2nd4 1248 17 ) ) -RRB- cord-009571-mygj2nd4 1248 18 virus virus NN cord-009571-mygj2nd4 1248 19 titers titer NNS cord-009571-mygj2nd4 1248 20 were be VBD cord-009571-mygj2nd4 1248 21 somewhat somewhat RB cord-009571-mygj2nd4 1248 22 low low JJ cord-009571-mygj2nd4 1248 23 , , , cord-009571-mygj2nd4 1248 24 and and CC cord-009571-mygj2nd4 1248 25 in in IN cord-009571-mygj2nd4 1248 26 the the DT cord-009571-mygj2nd4 1248 27 RA RA NNP cord-009571-mygj2nd4 1248 28 and and CC cord-009571-mygj2nd4 1248 29 AUD AUD NNP cord-009571-mygj2nd4 1248 30 groups group NNS cord-009571-mygj2nd4 1248 31 cytomegalovirus cytomegalovirus NN cord-009571-mygj2nd4 1248 32 titers titer NNS cord-009571-mygj2nd4 1248 33 were be VBD cord-009571-mygj2nd4 1248 34 low low JJ cord-009571-mygj2nd4 1248 35 . . . cord-009571-mygj2nd4 1249 1 In in IN cord-009571-mygj2nd4 1249 2 SLE SLE NNP cord-009571-mygj2nd4 1249 3 , , , cord-009571-mygj2nd4 1249 4 mumps mumps NN cord-009571-mygj2nd4 1249 5 virus virus NN cord-009571-mygj2nd4 1249 6 titers titer NNS cord-009571-mygj2nd4 1249 7 were be VBD cord-009571-mygj2nd4 1249 8 slightly slightly RB cord-009571-mygj2nd4 1249 9 higher high JJR cord-009571-mygj2nd4 1249 10 than than IN cord-009571-mygj2nd4 1249 11 in in IN cord-009571-mygj2nd4 1249 12 the the DT cord-009571-mygj2nd4 1249 13 other other JJ cord-009571-mygj2nd4 1249 14 groups group NNS cord-009571-mygj2nd4 1249 15 . . . cord-009571-mygj2nd4 1250 1 However however RB cord-009571-mygj2nd4 1250 2 , , , cord-009571-mygj2nd4 1250 3 in in IN cord-009571-mygj2nd4 1250 4 contrast contrast NN cord-009571-mygj2nd4 1250 5 to to IN cord-009571-mygj2nd4 1250 6 the the DT cord-009571-mygj2nd4 1250 7 occasional occasional JJ cord-009571-mygj2nd4 1250 8 difference difference NN cord-009571-mygj2nd4 1250 9 serologic serologic NNP cord-009571-mygj2nd4 1250 10 titrations titration NNS cord-009571-mygj2nd4 1250 11 with with IN cord-009571-mygj2nd4 1250 12 previously previously RB cord-009571-mygj2nd4 1250 13 mentioned mention VBN cord-009571-mygj2nd4 1250 14 antigens antigen NNS cord-009571-mygj2nd4 1250 15 , , , cord-009571-mygj2nd4 1250 16 highly highly RB cord-009571-mygj2nd4 1250 17 significant significant JJ cord-009571-mygj2nd4 1250 18 differences difference NNS cord-009571-mygj2nd4 1250 19 in in IN cord-009571-mygj2nd4 1250 20 antibody antibody NN cord-009571-mygj2nd4 1250 21 titers titer NNS cord-009571-mygj2nd4 1250 22 to to IN cord-009571-mygj2nd4 1250 23 all all DT cord-009571-mygj2nd4 1250 24 13 13 CD cord-009571-mygj2nd4 1250 25 domestic domestic JJ cord-009571-mygj2nd4 1250 26 Y Y NNP cord-009571-mygj2nd4 1250 27 enterocolitica enterocolitica NNP cord-009571-mygj2nd4 1250 28 antigens antigen NNS cord-009571-mygj2nd4 1250 29 ( ( -LRB- cord-009571-mygj2nd4 1250 30 7 7 CD cord-009571-mygj2nd4 1250 31 serotypes serotype NNS cord-009571-mygj2nd4 1250 32 ) ) -RRB- cord-009571-mygj2nd4 1250 33 were be VBD cord-009571-mygj2nd4 1250 34 found find VBN cord-009571-mygj2nd4 1250 35 among among IN cord-009571-mygj2nd4 1250 36 the the DT cord-009571-mygj2nd4 1250 37 groups group NNS cord-009571-mygj2nd4 1250 38 . . . cord-009571-mygj2nd4 1251 1 Arthritis arthritis NN cord-009571-mygj2nd4 1251 2 patients patient NNS cord-009571-mygj2nd4 1251 3 had have VBD cord-009571-mygj2nd4 1251 4 consistently consistently RB cord-009571-mygj2nd4 1251 5 lower low JJR cord-009571-mygj2nd4 1251 6 median median JJ cord-009571-mygj2nd4 1251 7 levels level NNS cord-009571-mygj2nd4 1251 8 than than IN cord-009571-mygj2nd4 1251 9 normal normal JJ cord-009571-mygj2nd4 1251 10 controls control NNS cord-009571-mygj2nd4 1251 11 with with IN cord-009571-mygj2nd4 1251 12 the the DT cord-009571-mygj2nd4 1251 13 lowest low JJS cord-009571-mygj2nd4 1251 14 titers titer NNS cord-009571-mygj2nd4 1251 15 found find VBN cord-009571-mygj2nd4 1251 16 in in IN cord-009571-mygj2nd4 1251 17 SLE SLE NNP cord-009571-mygj2nd4 1251 18 , , , cord-009571-mygj2nd4 1251 19 followed follow VBN cord-009571-mygj2nd4 1251 20 by by IN cord-009571-mygj2nd4 1251 21 JRA JRA NNP cord-009571-mygj2nd4 1251 22 , , , cord-009571-mygj2nd4 1251 23 AUD AUD NNP cord-009571-mygj2nd4 1251 24 , , , cord-009571-mygj2nd4 1251 25 and and CC cord-009571-mygj2nd4 1251 26 finally finally RB cord-009571-mygj2nd4 1251 27 the the DT cord-009571-mygj2nd4 1251 28 RA RA NNP cord-009571-mygj2nd4 1251 29 group group NN cord-009571-mygj2nd4 1251 30 . . . cord-009571-mygj2nd4 1252 1 The the DT cord-009571-mygj2nd4 1252 2 4 4 CD cord-009571-mygj2nd4 1252 3 Finnish Finnish NNP cord-009571-mygj2nd4 1252 4 Y Y NNP cord-009571-mygj2nd4 1252 5 enterocolitica enterocolitica NNP cord-009571-mygj2nd4 1252 6 antigens antigen NNS cord-009571-mygj2nd4 1252 7 ( ( -LRB- cord-009571-mygj2nd4 1252 8 serotypes serotype NNS cord-009571-mygj2nd4 1252 9 3 3 CD cord-009571-mygj2nd4 1252 10 and and CC cord-009571-mygj2nd4 1252 11 9 9 CD cord-009571-mygj2nd4 1252 12 ) ) -RRB- cord-009571-mygj2nd4 1252 13 showed show VBD cord-009571-mygj2nd4 1252 14 no no DT cord-009571-mygj2nd4 1252 15 significant significant JJ cord-009571-mygj2nd4 1252 16 difference difference NN cord-009571-mygj2nd4 1252 17 among among IN cord-009571-mygj2nd4 1252 18 groups group NNS cord-009571-mygj2nd4 1252 19 but but CC cord-009571-mygj2nd4 1252 20 yielded yield VBD cord-009571-mygj2nd4 1252 21 the the DT cord-009571-mygj2nd4 1252 22 lowest low JJS cord-009571-mygj2nd4 1252 23 median median NN cord-009571-mygj2nd4 1252 24 titers titer NNS cord-009571-mygj2nd4 1252 25 of of IN cord-009571-mygj2nd4 1252 26 all all DT cord-009571-mygj2nd4 1252 27 yersinia yersinia NNP cord-009571-mygj2nd4 1252 28 antigens antigen NNS cord-009571-mygj2nd4 1252 29 . . . cord-009571-mygj2nd4 1253 1 Evidence evidence NN cord-009571-mygj2nd4 1253 2 of of IN cord-009571-mygj2nd4 1253 3 yersinia yersinia NNP cord-009571-mygj2nd4 1253 4 reactive reactive JJ cord-009571-mygj2nd4 1253 5 arthritis arthritis NN cord-009571-mygj2nd4 1253 6 was be VBD cord-009571-mygj2nd4 1253 7 not not RB cord-009571-mygj2nd4 1253 8 found find VBN cord-009571-mygj2nd4 1253 9 in in IN cord-009571-mygj2nd4 1253 10 this this DT cord-009571-mygj2nd4 1253 11 patient patient JJ cord-009571-mygj2nd4 1253 12 sample sample NN cord-009571-mygj2nd4 1253 13 , , , cord-009571-mygj2nd4 1253 14 and and CC cord-009571-mygj2nd4 1253 15 median median JJ cord-009571-mygj2nd4 1253 16 antibody antibody NN cord-009571-mygj2nd4 1253 17 titers titer NNS cord-009571-mygj2nd4 1253 18 of of IN cord-009571-mygj2nd4 1253 19 the the DT cord-009571-mygj2nd4 1253 20 1 1 CD cord-009571-mygj2nd4 1253 21 1 1 CD cord-009571-mygj2nd4 1253 22 B27 B27 NNP cord-009571-mygj2nd4 1253 23 positive positive JJ cord-009571-mygj2nd4 1253 24 and and CC cord-009571-mygj2nd4 1253 25 76 76 CD cord-009571-mygj2nd4 1253 26 B27 b27 JJ cord-009571-mygj2nd4 1253 27 negative negative JJ cord-009571-mygj2nd4 1253 28 arthritis arthritis NN cord-009571-mygj2nd4 1253 29 patients patient NNS cord-009571-mygj2nd4 1253 30 without without IN cord-009571-mygj2nd4 1253 31 either either DT cord-009571-mygj2nd4 1253 32 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1253 33 factor factor NN cord-009571-mygj2nd4 1253 34 positivity positivity NN cord-009571-mygj2nd4 1253 35 or or CC cord-009571-mygj2nd4 1253 36 the the DT cord-009571-mygj2nd4 1253 37 diagnosis diagnosis NN cord-009571-mygj2nd4 1253 38 of of IN cord-009571-mygj2nd4 1253 39 SLE SLE NNP cord-009571-mygj2nd4 1253 40 were be VBD cord-009571-mygj2nd4 1253 41 highly highly RB cord-009571-mygj2nd4 1253 42 comparable comparable JJ cord-009571-mygj2nd4 1253 43 . . . cord-009571-mygj2nd4 1254 1 The the DT cord-009571-mygj2nd4 1254 2 results result NNS cord-009571-mygj2nd4 1254 3 provide provide VBP cord-009571-mygj2nd4 1254 4 no no DT cord-009571-mygj2nd4 1254 5 serologic serologic JJ cord-009571-mygj2nd4 1254 6 evidence evidence NN cord-009571-mygj2nd4 1254 7 of of IN cord-009571-mygj2nd4 1254 8 infectious infectious JJ cord-009571-mygj2nd4 1254 9 agent agent NN cord-009571-mygj2nd4 1254 10 association association NNP cord-009571-mygj2nd4 1254 11 with with IN cord-009571-mygj2nd4 1254 12 early early RB cord-009571-mygj2nd4 1254 13 - - HYPH cord-009571-mygj2nd4 1254 14 diagnosed diagnose VBN cord-009571-mygj2nd4 1254 15 arthritis arthritis NN cord-009571-mygj2nd4 1254 16 but but CC cord-009571-mygj2nd4 1254 17 reveal reveal VB cord-009571-mygj2nd4 1254 18 impressive impressive JJ cord-009571-mygj2nd4 1254 19 hyporeactivity hyporeactivity NN cord-009571-mygj2nd4 1254 20 to to IN cord-009571-mygj2nd4 1254 21 domestic domestic JJ cord-009571-mygj2nd4 1254 22 Y Y NNP cord-009571-mygj2nd4 1254 23 enierocoliticu enierocoliticu NNP cord-009571-mygj2nd4 1254 24 serotypes serotype NNS cord-009571-mygj2nd4 1254 25 which which WDT cord-009571-mygj2nd4 1254 26 suggests suggest VBZ cord-009571-mygj2nd4 1254 27 decreased decrease VBN cord-009571-mygj2nd4 1254 28 natural natural JJ cord-009571-mygj2nd4 1254 29 IgM IgM NNP cord-009571-mygj2nd4 1254 30 agglutinating agglutinate VBG cord-009571-mygj2nd4 1254 31 antibodies antibody NNS cord-009571-mygj2nd4 1254 32 to to TO cord-009571-mygj2nd4 1254 33 gram gram VB cord-009571-mygj2nd4 1254 34 negative negative JJ cord-009571-mygj2nd4 1254 35 organisms organism NNS cord-009571-mygj2nd4 1254 36 as as IN cord-009571-mygj2nd4 1254 37 previously previously RB cord-009571-mygj2nd4 1254 38 reported report VBN cord-009571-mygj2nd4 1254 39 in in IN cord-009571-mygj2nd4 1254 40 SLE SLE NNP cord-009571-mygj2nd4 1254 41 patients patient NNS cord-009571-mygj2nd4 1254 42 ( ( -LRB- cord-009571-mygj2nd4 1254 43 Baum Baum NNP cord-009571-mygj2nd4 1254 44 J J NNP cord-009571-mygj2nd4 1254 45 , , , cord-009571-mygj2nd4 1254 46 Ziff Ziff NNP cord-009571-mygj2nd4 1254 47 M M NNP cord-009571-mygj2nd4 1254 48 : : : cord-009571-mygj2nd4 1254 49 J J NNP cord-009571-mygj2nd4 1254 50 Clin Clin NNP cord-009571-mygj2nd4 1254 51 Invest Invest NNP cord-009571-mygj2nd4 1254 52 48:758 48:758 CD cord-009571-mygj2nd4 1254 53 , , , cord-009571-mygj2nd4 1254 54 1969 1969 CD cord-009571-mygj2nd4 1254 55 ) ) -RRB- cord-009571-mygj2nd4 1254 56 . . . cord-009571-mygj2nd4 1255 1 Among among IN cord-009571-mygj2nd4 1255 2 the the DT cord-009571-mygj2nd4 1255 3 various various JJ cord-009571-mygj2nd4 1255 4 microvascular microvascular JJ cord-009571-mygj2nd4 1255 5 abnormalities abnormality NNS cord-009571-mygj2nd4 1255 6 present present JJ cord-009571-mygj2nd4 1255 7 in in IN cord-009571-mygj2nd4 1255 8 the the DT cord-009571-mygj2nd4 1255 9 skin skin NN cord-009571-mygj2nd4 1255 10 of of IN cord-009571-mygj2nd4 1255 11 patients patient NNS cord-009571-mygj2nd4 1255 12 with with IN cord-009571-mygj2nd4 1255 13 connective connective JJ cord-009571-mygj2nd4 1255 14 tissue tissue NN cord-009571-mygj2nd4 1255 15 diseases disease NNS cord-009571-mygj2nd4 1255 16 and and CC cord-009571-mygj2nd4 1255 17 demonstrable demonstrable JJ cord-009571-mygj2nd4 1255 18 by by RB cord-009571-mygj2nd4 1255 19 in in IN cord-009571-mygj2nd4 1255 20 vivo vivo NN cord-009571-mygj2nd4 1255 21 microscopy microscopy NNS cord-009571-mygj2nd4 1255 22 , , , cord-009571-mygj2nd4 1255 23 the the DT cord-009571-mygj2nd4 1255 24 most most RBS cord-009571-mygj2nd4 1255 25 characteristic characteristic JJ cord-009571-mygj2nd4 1255 26 pattern pattern NN cord-009571-mygj2nd4 1255 27 of of IN cord-009571-mygj2nd4 1255 28 capillary capillary JJ cord-009571-mygj2nd4 1255 29 abnormalities abnormality NNS cord-009571-mygj2nd4 1255 30 is be VBZ cord-009571-mygj2nd4 1255 31 found find VBN cord-009571-mygj2nd4 1255 32 in in IN cord-009571-mygj2nd4 1255 33 patients patient NNS cord-009571-mygj2nd4 1255 34 with with IN cord-009571-mygj2nd4 1255 35 scleroderma scleroderma NNS cord-009571-mygj2nd4 1255 36 ( ( -LRB- cord-009571-mygj2nd4 1255 37 SD sd NN cord-009571-mygj2nd4 1255 38 ) ) -RRB- cord-009571-mygj2nd4 1255 39 ( ( -LRB- cord-009571-mygj2nd4 1255 40 Maricq Maricq NNP cord-009571-mygj2nd4 1255 41 HR HR NNP cord-009571-mygj2nd4 1255 42 , , , cord-009571-mygj2nd4 1255 43 Spencer Spencer NNP cord-009571-mygj2nd4 1255 44 - - HYPH cord-009571-mygj2nd4 1255 45 Green Green NNP cord-009571-mygj2nd4 1255 46 G G NNP cord-009571-mygj2nd4 1255 47 , , , cord-009571-mygj2nd4 1255 48 LeRoy LeRoy NNP cord-009571-mygj2nd4 1255 49 EC EC NNP cord-009571-mygj2nd4 1255 50 : : : cord-009571-mygj2nd4 1255 51 Skin skin NN cord-009571-mygj2nd4 1255 52 capillary capillary JJ cord-009571-mygj2nd4 1255 53 abnormalities abnormality NNS cord-009571-mygj2nd4 1255 54 as as IN cord-009571-mygj2nd4 1255 55 indicators indicator NNS cord-009571-mygj2nd4 1255 56 of of IN cord-009571-mygj2nd4 1255 57 organ organ NN cord-009571-mygj2nd4 1255 58 involvement involvement NN cord-009571-mygj2nd4 1255 59 in in IN cord-009571-mygj2nd4 1255 60 scleroderma scleroderma NN cord-009571-mygj2nd4 1255 61 ( ( -LRB- cord-009571-mygj2nd4 1255 62 systemic systemic JJ cord-009571-mygj2nd4 1255 63 sclerosis sclerosis NN cord-009571-mygj2nd4 1255 64 ) ) -RRB- cord-009571-mygj2nd4 1255 65 , , , cord-009571-mygj2nd4 1255 66 Raynaud Raynaud NNP cord-009571-mygj2nd4 1255 67 's 's POS cord-009571-mygj2nd4 1255 68 syndrome syndrome NN cord-009571-mygj2nd4 1255 69 , , , cord-009571-mygj2nd4 1255 70 and and CC cord-009571-mygj2nd4 1255 71 dermatomyositis dermatomyositis NNP cord-009571-mygj2nd4 1255 72 . . . cord-009571-mygj2nd4 1256 1 Amer Amer NNP cord-009571-mygj2nd4 1256 2 J J NNP cord-009571-mygj2nd4 1256 3 Med Med NNP cord-009571-mygj2nd4 1256 4 6 6 CD cord-009571-mygj2nd4 1256 5 1:862 1:862 CD cord-009571-mygj2nd4 1256 6 - - HYPH cord-009571-mygj2nd4 1256 7 870 870 CD cord-009571-mygj2nd4 1256 8 , , , cord-009571-mygj2nd4 1256 9 1976 1976 CD cord-009571-mygj2nd4 1256 10 ) ) -RRB- cord-009571-mygj2nd4 1256 11 . . . cord-009571-mygj2nd4 1257 1 The the DT cord-009571-mygj2nd4 1257 2 prevalence prevalence NN cord-009571-mygj2nd4 1257 3 of of IN cord-009571-mygj2nd4 1257 4 this this DT cord-009571-mygj2nd4 1257 5 SD sd NN cord-009571-mygj2nd4 1257 6 pattern pattern NN cord-009571-mygj2nd4 1257 7 in in IN cord-009571-mygj2nd4 1257 8 a a DT cord-009571-mygj2nd4 1257 9 larger large JJR cord-009571-mygj2nd4 1257 10 sample sample NN cord-009571-mygj2nd4 1257 11 of of IN cord-009571-mygj2nd4 1257 12 patients patient NNS cord-009571-mygj2nd4 1257 13 with with IN cord-009571-mygj2nd4 1257 14 SD sd NN cord-009571-mygj2nd4 1257 15 and and CC cord-009571-mygj2nd4 1257 16 related relate VBN cord-009571-mygj2nd4 1257 17 connective connective JJ cord-009571-mygj2nd4 1257 18 tissue tissue NN cord-009571-mygj2nd4 1257 19 diseases disease NNS cord-009571-mygj2nd4 1257 20 was be VBD cord-009571-mygj2nd4 1257 21 studied study VBN cord-009571-mygj2nd4 1257 22 in in IN cord-009571-mygj2nd4 1257 23 three three CD cord-009571-mygj2nd4 1257 24 separate separate JJ cord-009571-mygj2nd4 1257 25 Arthritis arthritis NN cord-009571-mygj2nd4 1257 26 Centers Centers NNPS cord-009571-mygj2nd4 1257 27 and and CC cord-009571-mygj2nd4 1257 28 in in IN cord-009571-mygj2nd4 1257 29 147 147 CD cord-009571-mygj2nd4 1257 30 patients patient NNS cord-009571-mygj2nd4 1257 31 with with IN cord-009571-mygj2nd4 1257 32 the the DT cord-009571-mygj2nd4 1257 33 following follow VBG cord-009571-mygj2nd4 1257 34 diagnoses diagnosis NNS cord-009571-mygj2nd4 1257 35 : : : cord-009571-mygj2nd4 1257 36 SF SF NNP cord-009571-mygj2nd4 1257 37 ( ( -LRB- cord-009571-mygj2nd4 1257 38 SO so RB cord-009571-mygj2nd4 1257 39 ) ) -RRB- cord-009571-mygj2nd4 1257 40 , , , cord-009571-mygj2nd4 1257 41 systemic systemic JJ cord-009571-mygj2nd4 1257 42 lupus lupus NN cord-009571-mygj2nd4 1257 43 erythematosus erythematosus NN cord-009571-mygj2nd4 1257 44 ( ( -LRB- cord-009571-mygj2nd4 1257 45 SLE SLE NNP cord-009571-mygj2nd4 1257 46 , , , cord-009571-mygj2nd4 1257 47 a a LS cord-009571-mygj2nd4 1257 48 ) ) -RRB- cord-009571-mygj2nd4 1257 49 , , , cord-009571-mygj2nd4 1257 50 mixed mix VBN cord-009571-mygj2nd4 1257 51 connective connective JJ cord-009571-mygj2nd4 1257 52 tissue tissue NN cord-009571-mygj2nd4 1257 53 disease disease NN cord-009571-mygj2nd4 1257 54 ( ( -LRB- cord-009571-mygj2nd4 1257 55 MCTD MCTD NNP cord-009571-mygj2nd4 1257 56 , , , cord-009571-mygj2nd4 1257 57 26 26 CD cord-009571-mygj2nd4 1257 58 ) ) -RRB- cord-009571-mygj2nd4 1257 59 , , , cord-009571-mygj2nd4 1257 60 and and CC cord-009571-mygj2nd4 1257 61 Raynaud Raynaud NNP cord-009571-mygj2nd4 1257 62 disease disease NN cord-009571-mygj2nd4 1257 63 ( ( -LRB- cord-009571-mygj2nd4 1257 64 RD RD NNP cord-009571-mygj2nd4 1257 65 , , , cord-009571-mygj2nd4 1257 66 11 11 CD cord-009571-mygj2nd4 1257 67 ) ) -RRB- cord-009571-mygj2nd4 1257 68 . . . cord-009571-mygj2nd4 1258 1 Results result NNS cord-009571-mygj2nd4 1258 2 from from IN cord-009571-mygj2nd4 1258 3 widefield widefield JJ cord-009571-mygj2nd4 1258 4 microscopic microscopic JJ cord-009571-mygj2nd4 1258 5 observations observation NNS cord-009571-mygj2nd4 1258 6 and and CC cord-009571-mygj2nd4 1258 7 photomicrography photomicrography NN cord-009571-mygj2nd4 1258 8 show show VBP cord-009571-mygj2nd4 1258 9 SD sd NN cord-009571-mygj2nd4 1258 10 - - HYPH cord-009571-mygj2nd4 1258 11 type type NN cord-009571-mygj2nd4 1258 12 capillary capillary JJ cord-009571-mygj2nd4 1258 13 abnormalities abnormality NNS cord-009571-mygj2nd4 1258 14 present present JJ cord-009571-mygj2nd4 1258 15 in in IN cord-009571-mygj2nd4 1258 16 the the DT cord-009571-mygj2nd4 1258 17 following follow VBG cord-009571-mygj2nd4 1258 18 numbers number NNS cord-009571-mygj2nd4 1258 19 of of IN cord-009571-mygj2nd4 1258 20 patients patient NNS cord-009571-mygj2nd4 1258 21 in in IN cord-009571-mygj2nd4 1258 22 each each DT cord-009571-mygj2nd4 1258 23 diagnostic diagnostic JJ cord-009571-mygj2nd4 1258 24 category category NN cord-009571-mygj2nd4 1258 25 : : : cord-009571-mygj2nd4 1258 26 SD sd NN cord-009571-mygj2nd4 1258 27 , , , cord-009571-mygj2nd4 1258 28 41 41 CD cord-009571-mygj2nd4 1258 29 ( ( -LRB- cord-009571-mygj2nd4 1258 30 82 82 CD cord-009571-mygj2nd4 1258 31 % % NN cord-009571-mygj2nd4 1258 32 ) ) -RRB- cord-009571-mygj2nd4 1258 33 ; ; : cord-009571-mygj2nd4 1258 34 SLE SLE NNP cord-009571-mygj2nd4 1258 35 , , , cord-009571-mygj2nd4 1258 36 1 1 CD cord-009571-mygj2nd4 1258 37 ( ( -LRB- cord-009571-mygj2nd4 1258 38 2 2 CD cord-009571-mygj2nd4 1258 39 % % NN cord-009571-mygj2nd4 1258 40 ) ) -RRB- cord-009571-mygj2nd4 1258 41 ; ; : cord-009571-mygj2nd4 1258 42 MCTD MCTD NNP cord-009571-mygj2nd4 1258 43 , , , cord-009571-mygj2nd4 1258 44 14 14 CD cord-009571-mygj2nd4 1258 45 ( ( -LRB- cord-009571-mygj2nd4 1258 46 54 54 CD cord-009571-mygj2nd4 1258 47 % % NN cord-009571-mygj2nd4 1258 48 ) ) -RRB- cord-009571-mygj2nd4 1258 49 ; ; : cord-009571-mygj2nd4 1258 50 and and CC cord-009571-mygj2nd4 1258 51 RD RD NNP cord-009571-mygj2nd4 1258 52 , , , cord-009571-mygj2nd4 1258 53 1 1 CD cord-009571-mygj2nd4 1258 54 ( ( -LRB- cord-009571-mygj2nd4 1258 55 % % NN cord-009571-mygj2nd4 1258 56 ) ) -RRB- cord-009571-mygj2nd4 1258 57 . . . cord-009571-mygj2nd4 1259 1 Tortuous tortuous JJ cord-009571-mygj2nd4 1259 2 capillaries capillary NNS cord-009571-mygj2nd4 1259 3 were be VBD cord-009571-mygj2nd4 1259 4 noticed notice VBN cord-009571-mygj2nd4 1259 5 in in IN cord-009571-mygj2nd4 1259 6 25 25 CD cord-009571-mygj2nd4 1259 7 patients patient NNS cord-009571-mygj2nd4 1259 8 with with IN cord-009571-mygj2nd4 1259 9 SLE SLE NNP cord-009571-mygj2nd4 1259 10 ( ( -LRB- cord-009571-mygj2nd4 1259 11 42 42 CD cord-009571-mygj2nd4 1259 12 % % NN cord-009571-mygj2nd4 1259 13 ) ) -RRB- cord-009571-mygj2nd4 1259 14 , , , cord-009571-mygj2nd4 1259 15 3 3 CD cord-009571-mygj2nd4 1259 16 with with IN cord-009571-mygj2nd4 1259 17 SD SD NNP cord-009571-mygj2nd4 1259 18 ( ( -LRB- cord-009571-mygj2nd4 1259 19 6 6 CD cord-009571-mygj2nd4 1259 20 % % NN cord-009571-mygj2nd4 1259 21 ) ) -RRB- cord-009571-mygj2nd4 1259 22 . . . cord-009571-mygj2nd4 1260 1 3 3 CD cord-009571-mygj2nd4 1260 2 with with IN cord-009571-mygj2nd4 1260 3 MCTD MCTD NNP cord-009571-mygj2nd4 1260 4 ( ( -LRB- cord-009571-mygj2nd4 1260 5 12 12 CD cord-009571-mygj2nd4 1260 6 % % NN cord-009571-mygj2nd4 1260 7 ) ) -RRB- cord-009571-mygj2nd4 1260 8 , , , cord-009571-mygj2nd4 1260 9 and and CC cord-009571-mygj2nd4 1260 10 4 4 CD cord-009571-mygj2nd4 1260 11 with with IN cord-009571-mygj2nd4 1260 12 R R NNP cord-009571-mygj2nd4 1260 13 D d NN cord-009571-mygj2nd4 1260 14 ( ( -LRB- cord-009571-mygj2nd4 1260 15 36 36 CD cord-009571-mygj2nd4 1260 16 % % NN cord-009571-mygj2nd4 1260 17 ) ) -RRB- cord-009571-mygj2nd4 1260 18 . . . cord-009571-mygj2nd4 1261 1 Only only RB cord-009571-mygj2nd4 1261 2 2 2 CD cord-009571-mygj2nd4 1261 3 patients patient NNS cord-009571-mygj2nd4 1261 4 ( ( -LRB- cord-009571-mygj2nd4 1261 5 with with IN cord-009571-mygj2nd4 1261 6 MCTD MCTD NNP cord-009571-mygj2nd4 1261 7 ) ) -RRB- cord-009571-mygj2nd4 1261 8 had have VBD cord-009571-mygj2nd4 1261 9 both both CC cord-009571-mygj2nd4 1261 10 a a DT cord-009571-mygj2nd4 1261 11 SD sd NN cord-009571-mygj2nd4 1261 12 pattern pattern NN cord-009571-mygj2nd4 1261 13 and and CC cord-009571-mygj2nd4 1261 14 tortuous tortuous JJ cord-009571-mygj2nd4 1261 15 capillaries capillary NNS cord-009571-mygj2nd4 1261 16 ( ( -LRB- cord-009571-mygj2nd4 1261 17 8 8 CD cord-009571-mygj2nd4 1261 18 % % NN cord-009571-mygj2nd4 1261 19 of of IN cord-009571-mygj2nd4 1261 20 MCTD MCTD NNP cord-009571-mygj2nd4 1261 21 or or CC cord-009571-mygj2nd4 1261 22 1 1 CD cord-009571-mygj2nd4 1261 23 % % NN cord-009571-mygj2nd4 1261 24 of of IN cord-009571-mygj2nd4 1261 25 all all DT cord-009571-mygj2nd4 1261 26 patients patient NNS cord-009571-mygj2nd4 1261 27 ) ) -RRB- cord-009571-mygj2nd4 1261 28 . . . cord-009571-mygj2nd4 1262 1 Non non JJ cord-009571-mygj2nd4 1262 2 - - JJ cord-009571-mygj2nd4 1262 3 specific specific JJ cord-009571-mygj2nd4 1262 4 microvascular microvascular JJ cord-009571-mygj2nd4 1262 5 changes change NNS cord-009571-mygj2nd4 1262 6 were be VBD cord-009571-mygj2nd4 1262 7 present present JJ cord-009571-mygj2nd4 1262 8 in in IN cord-009571-mygj2nd4 1262 9 17 17 CD cord-009571-mygj2nd4 1262 10 patients patient NNS cord-009571-mygj2nd4 1262 11 with with IN cord-009571-mygj2nd4 1262 12 SLE SLE NNP cord-009571-mygj2nd4 1262 13 ( ( -LRB- cord-009571-mygj2nd4 1262 14 28 28 CD cord-009571-mygj2nd4 1262 15 % % NN cord-009571-mygj2nd4 1262 16 ) ) -RRB- cord-009571-mygj2nd4 1262 17 , , , cord-009571-mygj2nd4 1262 18 4 4 CD cord-009571-mygj2nd4 1262 19 with with IN cord-009571-mygj2nd4 1262 20 SD SD NNP cord-009571-mygj2nd4 1262 21 ( ( -LRB- cord-009571-mygj2nd4 1262 22 8 8 CD cord-009571-mygj2nd4 1262 23 % % NN cord-009571-mygj2nd4 1262 24 ) ) -RRB- cord-009571-mygj2nd4 1262 25 , , , cord-009571-mygj2nd4 1262 26 3 3 CD cord-009571-mygj2nd4 1262 27 with with IN cord-009571-mygj2nd4 1262 28 MCTD MCTD NNP cord-009571-mygj2nd4 1262 29 ( ( -LRB- cord-009571-mygj2nd4 1262 30 12 12 CD cord-009571-mygj2nd4 1262 31 % % NN cord-009571-mygj2nd4 1262 32 ) ) -RRB- cord-009571-mygj2nd4 1262 33 , , , cord-009571-mygj2nd4 1262 34 and and CC cord-009571-mygj2nd4 1262 35 2 2 CD cord-009571-mygj2nd4 1262 36 with with IN cord-009571-mygj2nd4 1262 37 RD RD NNP cord-009571-mygj2nd4 1262 38 ( ( -LRB- cord-009571-mygj2nd4 1262 39 18 18 CD cord-009571-mygj2nd4 1262 40 % % NN cord-009571-mygj2nd4 1262 41 ) ) -RRB- cord-009571-mygj2nd4 1262 42 . . . cord-009571-mygj2nd4 1263 1 Many many JJ cord-009571-mygj2nd4 1263 2 SLE SLE NNP cord-009571-mygj2nd4 1263 3 ( ( -LRB- cord-009571-mygj2nd4 1263 4 17 17 CD cord-009571-mygj2nd4 1263 5 patients patient NNS cord-009571-mygj2nd4 1263 6 , , , cord-009571-mygj2nd4 1263 7 28 28 CD cord-009571-mygj2nd4 1263 8 % % NN cord-009571-mygj2nd4 1263 9 ) ) -RRB- cord-009571-mygj2nd4 1263 10 and and CC cord-009571-mygj2nd4 1263 11 R r NN cord-009571-mygj2nd4 1263 12 D d NN cord-009571-mygj2nd4 1263 13 ( ( -LRB- cord-009571-mygj2nd4 1263 14 4 4 CD cord-009571-mygj2nd4 1263 15 patients patient NNS cord-009571-mygj2nd4 1263 16 , , , cord-009571-mygj2nd4 1263 17 36 36 CD cord-009571-mygj2nd4 1263 18 % % NN cord-009571-mygj2nd4 1263 19 ) ) -RRB- cord-009571-mygj2nd4 1263 20 patients patient NNS cord-009571-mygj2nd4 1263 21 showed show VBD cord-009571-mygj2nd4 1263 22 no no DT cord-009571-mygj2nd4 1263 23 capillary capillary JJ cord-009571-mygj2nd4 1263 24 abnormalities abnormality NNS cord-009571-mygj2nd4 1263 25 , , , cord-009571-mygj2nd4 1263 26 as as IN cord-009571-mygj2nd4 1263 27 did do VBD cord-009571-mygj2nd4 1263 28 6 6 CD cord-009571-mygj2nd4 1263 29 patients patient NNS cord-009571-mygj2nd4 1263 30 with with IN cord-009571-mygj2nd4 1263 31 MCTD MCTD NNP cord-009571-mygj2nd4 1263 32 ( ( -LRB- cord-009571-mygj2nd4 1263 33 23 23 CD cord-009571-mygj2nd4 1263 34 % % NN cord-009571-mygj2nd4 1263 35 ) ) -RRB- cord-009571-mygj2nd4 1263 36 but but CC cord-009571-mygj2nd4 1263 37 only only RB cord-009571-mygj2nd4 1263 38 2 2 CD cord-009571-mygj2nd4 1263 39 with with IN cord-009571-mygj2nd4 1263 40 SD sd NN cord-009571-mygj2nd4 1263 41 ( ( -LRB- cord-009571-mygj2nd4 1263 42 4 4 CD cord-009571-mygj2nd4 1263 43 % % NN cord-009571-mygj2nd4 1263 44 ) ) -RRB- cord-009571-mygj2nd4 1263 45 . . . cord-009571-mygj2nd4 1264 1 These these DT cord-009571-mygj2nd4 1264 2 results result NNS cord-009571-mygj2nd4 1264 3 confirm confirm VBP cord-009571-mygj2nd4 1264 4 the the DT cord-009571-mygj2nd4 1264 5 high high JJ cord-009571-mygj2nd4 1264 6 frequency frequency NN cord-009571-mygj2nd4 1264 7 of of IN cord-009571-mygj2nd4 1264 8 SD sd NN cord-009571-mygj2nd4 1264 9 - - HYPH cord-009571-mygj2nd4 1264 10 type type NN cord-009571-mygj2nd4 1264 11 capillary capillary JJ cord-009571-mygj2nd4 1264 12 pattern pattern NN cord-009571-mygj2nd4 1264 13 in in IN cord-009571-mygj2nd4 1264 14 SD sd NN cord-009571-mygj2nd4 1264 15 patients patient NNS cord-009571-mygj2nd4 1264 16 and and CC cord-009571-mygj2nd4 1264 17 separate separate VB cord-009571-mygj2nd4 1264 18 them -PRON- PRP cord-009571-mygj2nd4 1264 19 from from IN cord-009571-mygj2nd4 1264 20 patients patient NNS cord-009571-mygj2nd4 1264 21 with with IN cord-009571-mygj2nd4 1264 22 SLE SLE NNP cord-009571-mygj2nd4 1264 23 , , , cord-009571-mygj2nd4 1264 24 who who WP cord-009571-mygj2nd4 1264 25 do do VBP cord-009571-mygj2nd4 1264 26 not not RB cord-009571-mygj2nd4 1264 27 show show VB cord-009571-mygj2nd4 1264 28 a a DT cord-009571-mygj2nd4 1264 29 pathognomonic pathognomonic JJ cord-009571-mygj2nd4 1264 30 pattern pattern NN cord-009571-mygj2nd4 1264 31 by by IN cord-009571-mygj2nd4 1264 32 the the DT cord-009571-mygj2nd4 1264 33 present present JJ cord-009571-mygj2nd4 1264 34 techniques technique NNS cord-009571-mygj2nd4 1264 35 . . . cord-009571-mygj2nd4 1265 1 Tortuous tortuous JJ cord-009571-mygj2nd4 1265 2 capillaries capillary NNS cord-009571-mygj2nd4 1265 3 , , , cord-009571-mygj2nd4 1265 4 frequent frequent JJ cord-009571-mygj2nd4 1265 5 in in IN cord-009571-mygj2nd4 1265 6 SLE SLE NNP cord-009571-mygj2nd4 1265 7 , , , cord-009571-mygj2nd4 1265 8 occur occur VBP cord-009571-mygj2nd4 1265 9 in in IN cord-009571-mygj2nd4 1265 10 other other JJ cord-009571-mygj2nd4 1265 11 diseases disease NNS cord-009571-mygj2nd4 1265 12 and and CC cord-009571-mygj2nd4 1265 13 in in IN cord-009571-mygj2nd4 1265 14 normal normal JJ cord-009571-mygj2nd4 1265 15 subjects subject NNS cord-009571-mygj2nd4 1265 16 , , , cord-009571-mygj2nd4 1265 17 although although IN cord-009571-mygj2nd4 1265 18 to to IN cord-009571-mygj2nd4 1265 19 a a DT cord-009571-mygj2nd4 1265 20 lesser less JJR cord-009571-mygj2nd4 1265 21 degree degree NN cord-009571-mygj2nd4 1265 22 . . . cord-009571-mygj2nd4 1266 1 It -PRON- PRP cord-009571-mygj2nd4 1266 2 is be VBZ cord-009571-mygj2nd4 1266 3 interesting interesting JJ cord-009571-mygj2nd4 1266 4 to to TO cord-009571-mygj2nd4 1266 5 note note VB cord-009571-mygj2nd4 1266 6 that that IN cord-009571-mygj2nd4 1266 7 patients patient NNS cord-009571-mygj2nd4 1266 8 with with IN cord-009571-mygj2nd4 1266 9 MCTD MCTD NNP cord-009571-mygj2nd4 1266 10 , , , cord-009571-mygj2nd4 1266 11 an an DT cord-009571-mygj2nd4 1266 12 overlap overlap NN cord-009571-mygj2nd4 1266 13 syndrome syndrome NN cord-009571-mygj2nd4 1266 14 having have VBG cord-009571-mygj2nd4 1266 15 clinical clinical JJ cord-009571-mygj2nd4 1266 16 features feature NNS cord-009571-mygj2nd4 1266 17 of of IN cord-009571-mygj2nd4 1266 18 both both DT cord-009571-mygj2nd4 1266 19 SD SD NNP cord-009571-mygj2nd4 1266 20 and and CC cord-009571-mygj2nd4 1266 21 SLE SLE NNP cord-009571-mygj2nd4 1266 22 , , , cord-009571-mygj2nd4 1266 23 exhibited exhibit VBD cord-009571-mygj2nd4 1266 24 no no DT cord-009571-mygj2nd4 1266 25 specific specific JJ cord-009571-mygj2nd4 1266 26 pattern pattern NN cord-009571-mygj2nd4 1266 27 of of IN cord-009571-mygj2nd4 1266 28 capillary capillary JJ cord-009571-mygj2nd4 1266 29 abnormalities abnormality NNS cord-009571-mygj2nd4 1266 30 . . . cord-009571-mygj2nd4 1267 1 About about RB cord-009571-mygj2nd4 1267 2 half half NN cord-009571-mygj2nd4 1267 3 of of IN cord-009571-mygj2nd4 1267 4 the the DT cord-009571-mygj2nd4 1267 5 patients patient NNS cord-009571-mygj2nd4 1267 6 showed show VBD cord-009571-mygj2nd4 1267 7 SD sd NN cord-009571-mygj2nd4 1267 8 pattern pattern NN cord-009571-mygj2nd4 1267 9 , , , cord-009571-mygj2nd4 1267 10 and and CC cord-009571-mygj2nd4 1267 11 the the DT cord-009571-mygj2nd4 1267 12 other other JJ cord-009571-mygj2nd4 1267 13 half half NN cord-009571-mygj2nd4 1267 14 demonstrated demonstrate VBN cord-009571-mygj2nd4 1267 15 tortuous tortuous JJ cord-009571-mygj2nd4 1267 16 capillaries capillary NNS cord-009571-mygj2nd4 1267 17 , , , cord-009571-mygj2nd4 1267 18 other other JJ cord-009571-mygj2nd4 1267 19 non non JJ cord-009571-mygj2nd4 1267 20 - - JJ cord-009571-mygj2nd4 1267 21 specific specific JJ cord-009571-mygj2nd4 1267 22 changes change NNS cord-009571-mygj2nd4 1267 23 , , , cord-009571-mygj2nd4 1267 24 or or CC cord-009571-mygj2nd4 1267 25 no no DT cord-009571-mygj2nd4 1267 26 observable observable JJ cord-009571-mygj2nd4 1267 27 microvascular microvascular JJ cord-009571-mygj2nd4 1267 28 abnormalities abnormality NNS cord-009571-mygj2nd4 1267 29 . . . cord-009571-mygj2nd4 1268 1 Clinical clinical JJ cord-009571-mygj2nd4 1268 2 criteria criterion NNS cord-009571-mygj2nd4 1268 3 for for IN cord-009571-mygj2nd4 1268 4 classification classification NN cord-009571-mygj2nd4 1268 5 of of IN cord-009571-mygj2nd4 1268 6 systemic systemic JJ cord-009571-mygj2nd4 1268 7 sclerosis sclerosis NN cord-009571-mygj2nd4 1268 8 ( ( -LRB- cord-009571-mygj2nd4 1268 9 SS SS NNP cord-009571-mygj2nd4 1268 10 ) ) -RRB- cord-009571-mygj2nd4 1268 11 were be VBD cord-009571-mygj2nd4 1268 12 derived derive VBN cord-009571-mygj2nd4 1268 13 from from IN cord-009571-mygj2nd4 1268 14 prospectively prospectively RB cord-009571-mygj2nd4 1268 15 entered enter VBN cord-009571-mygj2nd4 1268 16 data datum NNS cord-009571-mygj2nd4 1268 17 on on IN cord-009571-mygj2nd4 1268 18 799 799 CD cord-009571-mygj2nd4 1268 19 early early RB cord-009571-mygj2nd4 1268 20 - - HYPH cord-009571-mygj2nd4 1268 21 diagnosed diagnose VBN cord-009571-mygj2nd4 1268 22 rheumatic rheumatic JJ cord-009571-mygj2nd4 1268 23 patients patient NNS cord-009571-mygj2nd4 1268 24 contributed contribute VBN cord-009571-mygj2nd4 1268 25 by by IN cord-009571-mygj2nd4 1268 26 29 29 CD cord-009571-mygj2nd4 1268 27 centers center NNS cord-009571-mygj2nd4 1268 28 . . . cord-009571-mygj2nd4 1269 1 Cases case NNS cord-009571-mygj2nd4 1269 2 included include VBD cord-009571-mygj2nd4 1269 3 patients patient NNS cord-009571-mygj2nd4 1269 4 with with IN cord-009571-mygj2nd4 1269 5 definite definite JJ cord-009571-mygj2nd4 1269 6 or or CC cord-009571-mygj2nd4 1269 7 probable probable JJ cord-009571-mygj2nd4 1269 8 SS ss NN cord-009571-mygj2nd4 1269 9 , , , cord-009571-mygj2nd4 1269 10 or or CC cord-009571-mygj2nd4 1269 11 scleroderma scleroderma NN cord-009571-mygj2nd4 1269 12 in in IN cord-009571-mygj2nd4 1269 13 overlap overlap NN cord-009571-mygj2nd4 1269 14 . . . cord-009571-mygj2nd4 1270 1 Controls control NNS cord-009571-mygj2nd4 1270 2 were be VBD cord-009571-mygj2nd4 1270 3 patients patient NNS cord-009571-mygj2nd4 1270 4 with with IN cord-009571-mygj2nd4 1270 5 systemic systemic JJ cord-009571-mygj2nd4 1270 6 lupus lupus NN cord-009571-mygj2nd4 1270 7 erythematosus erythematosus NN cord-009571-mygj2nd4 1270 8 ( ( -LRB- cord-009571-mygj2nd4 1270 9 SLE SLE NNP cord-009571-mygj2nd4 1270 10 ) ) -RRB- cord-009571-mygj2nd4 1270 11 , , , cord-009571-mygj2nd4 1270 12 polydermatomyositis polydermatomyositis NNP cord-009571-mygj2nd4 1270 13 , , , cord-009571-mygj2nd4 1270 14 or or CC cord-009571-mygj2nd4 1270 15 Raynaud Raynaud NNP cord-009571-mygj2nd4 1270 16 's 's POS cord-009571-mygj2nd4 1270 17 phenomenon phenomenon NN cord-009571-mygj2nd4 1270 18 alone alone RB cord-009571-mygj2nd4 1270 19 . . . cord-009571-mygj2nd4 1271 1 Computer computer NN cord-009571-mygj2nd4 1271 2 assisted assist VBN cord-009571-mygj2nd4 1271 3 and and CC cord-009571-mygj2nd4 1271 4 multivariate multivariate JJ cord-009571-mygj2nd4 1271 5 analysis analysis NN cord-009571-mygj2nd4 1271 6 techniques technique NNS cord-009571-mygj2nd4 1271 7 were be VBD cord-009571-mygj2nd4 1271 8 used use VBN cord-009571-mygj2nd4 1271 9 to to TO cord-009571-mygj2nd4 1271 10 construct construct VB cord-009571-mygj2nd4 1271 11 criteria criterion NNS cord-009571-mygj2nd4 1271 12 with with IN cord-009571-mygj2nd4 1271 13 minimal minimal JJ cord-009571-mygj2nd4 1271 14 redundancy redundancy NN cord-009571-mygj2nd4 1271 15 . . . cord-009571-mygj2nd4 1272 1 Careful careful JJ cord-009571-mygj2nd4 1272 2 definition definition NN cord-009571-mygj2nd4 1272 3 of of IN cord-009571-mygj2nd4 1272 4 cutaneous cutaneous JJ cord-009571-mygj2nd4 1272 5 involvement involvement NN cord-009571-mygj2nd4 1272 6 contributed contribute VBD cord-009571-mygj2nd4 1272 7 the the DT cord-009571-mygj2nd4 1272 8 most most RBS cord-009571-mygj2nd4 1272 9 powerful powerful JJ cord-009571-mygj2nd4 1272 10 criteria criterion NNS cord-009571-mygj2nd4 1272 11 . . . cord-009571-mygj2nd4 1273 1 Sclerodermatous sclerodermatous JJ cord-009571-mygj2nd4 1273 2 involvement involvement NN cord-009571-mygj2nd4 1273 3 proximal proximal JJ cord-009571-mygj2nd4 1273 4 to to IN cord-009571-mygj2nd4 1273 5 the the DT cord-009571-mygj2nd4 1273 6 metacarpal metacarpal NNP cord-009571-mygj2nd4 1273 7 phalangeal phalangeal NNP cord-009571-mygj2nd4 1273 8 or or CC cord-009571-mygj2nd4 1273 9 metatarsal metatarsal NNP cord-009571-mygj2nd4 1273 10 phala phala NNP cord-009571-mygj2nd4 1273 11 - - HYPH cord-009571-mygj2nd4 1273 12 ngeal ngeal JJ cord-009571-mygj2nd4 1273 13 joints joint NNS cord-009571-mygj2nd4 1273 14 ( ( -LRB- cord-009571-mygj2nd4 1274 1 ie ie NNP cord-009571-mygj2nd4 1274 2 , , , cord-009571-mygj2nd4 1274 3 " " `` cord-009571-mygj2nd4 1274 4 proximal proximal JJ cord-009571-mygj2nd4 1274 5 " " '' cord-009571-mygj2nd4 1274 6 scleroderma scleroderma NNS cord-009571-mygj2nd4 1274 7 ) ) -RRB- cord-009571-mygj2nd4 1274 8 , , , cord-009571-mygj2nd4 1274 9 whether whether IN cord-009571-mygj2nd4 1274 10 in in IN cord-009571-mygj2nd4 1274 11 an an DT cord-009571-mygj2nd4 1274 12 acrosclerotic acrosclerotic JJ cord-009571-mygj2nd4 1274 13 distribution distribution NN cord-009571-mygj2nd4 1274 14 ( ( -LRB- cord-009571-mygj2nd4 1274 15 acrosclerosis acrosclerosis NNP cord-009571-mygj2nd4 1274 16 ) ) -RRB- cord-009571-mygj2nd4 1274 17 , , , cord-009571-mygj2nd4 1274 18 on on IN cord-009571-mygj2nd4 1274 19 the the DT cord-009571-mygj2nd4 1274 20 face face NN cord-009571-mygj2nd4 1274 21 or or CC cord-009571-mygj2nd4 1274 22 neck neck NN cord-009571-mygj2nd4 1274 23 ( ( -LRB- cord-009571-mygj2nd4 1274 24 scleroderma scleroderma NN cord-009571-mygj2nd4 1274 25 facies facie NNS cord-009571-mygj2nd4 1274 26 ) ) -RRB- cord-009571-mygj2nd4 1274 27 , , , cord-009571-mygj2nd4 1274 28 or or CC cord-009571-mygj2nd4 1274 29 on on IN cord-009571-mygj2nd4 1274 30 the the DT cord-009571-mygj2nd4 1274 31 trunk trunk NN cord-009571-mygj2nd4 1274 32 or or CC cord-009571-mygj2nd4 1274 33 abdomen abdomen NN cord-009571-mygj2nd4 1274 34 , , , cord-009571-mygj2nd4 1274 35 was be VBD cord-009571-mygj2nd4 1274 36 present present JJ cord-009571-mygj2nd4 1274 37 in in IN cord-009571-mygj2nd4 1274 38 91 91 CD cord-009571-mygj2nd4 1274 39 % % NN cord-009571-mygj2nd4 1274 40 of of IN cord-009571-mygj2nd4 1274 41 definite definite JJ cord-009571-mygj2nd4 1274 42 SS SS NNP cord-009571-mygj2nd4 1274 43 cases case NNS cord-009571-mygj2nd4 1274 44 and and CC cord-009571-mygj2nd4 1274 45 in in IN cord-009571-mygj2nd4 1274 46 only only RB cord-009571-mygj2nd4 1274 47 1 1 CD cord-009571-mygj2nd4 1274 48 % % NN cord-009571-mygj2nd4 1274 49 of of IN cord-009571-mygj2nd4 1274 50 combined combined JJ cord-009571-mygj2nd4 1274 51 controls control NNS cord-009571-mygj2nd4 1274 52 . . . cord-009571-mygj2nd4 1275 1 If if IN cord-009571-mygj2nd4 1275 2 the the DT cord-009571-mygj2nd4 1275 3 major major JJ cord-009571-mygj2nd4 1275 4 criterion criterion NN cord-009571-mygj2nd4 1275 5 of of IN cord-009571-mygj2nd4 1275 6 proximal proximal JJ cord-009571-mygj2nd4 1275 7 scleroderma scleroderma NNS cord-009571-mygj2nd4 1275 8 was be VBD cord-009571-mygj2nd4 1275 9 absent absent JJ cord-009571-mygj2nd4 1275 10 , , , cord-009571-mygj2nd4 1275 11 SS SS NNP cord-009571-mygj2nd4 1275 12 cases case NNS cord-009571-mygj2nd4 1275 13 could could MD cord-009571-mygj2nd4 1275 14 be be VB cord-009571-mygj2nd4 1275 15 distinguished distinguish VBN cord-009571-mygj2nd4 1275 16 by by IN cord-009571-mygj2nd4 1275 17 having have VBG cord-009571-mygj2nd4 1275 18 at at RB cord-009571-mygj2nd4 1275 19 least least JJS cord-009571-mygj2nd4 1275 20 2 2 CD cord-009571-mygj2nd4 1275 21 of of IN cord-009571-mygj2nd4 1275 22 4 4 CD cord-009571-mygj2nd4 1275 23 minor minor JJ cord-009571-mygj2nd4 1275 24 criteria criterion NNS cord-009571-mygj2nd4 1275 25 , , , cord-009571-mygj2nd4 1275 26 ie ie NNS cord-009571-mygj2nd4 1275 27 , , , cord-009571-mygj2nd4 1275 28 sclerodactyly sclerodactyly NNP cord-009571-mygj2nd4 1275 29 , , , cord-009571-mygj2nd4 1275 30 digital digital JJ cord-009571-mygj2nd4 1275 31 pitting pit VBG cord-009571-mygj2nd4 1275 32 scars scar NNS cord-009571-mygj2nd4 1275 33 , , , cord-009571-mygj2nd4 1275 34 pulmonary pulmonary JJ cord-009571-mygj2nd4 1275 35 fibrosis fibrosis NN cord-009571-mygj2nd4 1275 36 , , , cord-009571-mygj2nd4 1275 37 or or CC cord-009571-mygj2nd4 1275 38 large large JJ cord-009571-mygj2nd4 1275 39 bowel bowel NN cord-009571-mygj2nd4 1275 40 sacculations sacculation NNS cord-009571-mygj2nd4 1275 41 . . . cord-009571-mygj2nd4 1276 1 Employing employ VBG cord-009571-mygj2nd4 1276 2 the the DT cord-009571-mygj2nd4 1276 3 major major JJ cord-009571-mygj2nd4 1276 4 with with IN cord-009571-mygj2nd4 1276 5 minor minor JJ cord-009571-mygj2nd4 1276 6 criteria criterion NNS cord-009571-mygj2nd4 1276 7 yielded yield VBD cord-009571-mygj2nd4 1276 8 98 98 CD cord-009571-mygj2nd4 1276 9 % % NN cord-009571-mygj2nd4 1276 10 sensitivity sensitivity NN cord-009571-mygj2nd4 1276 11 in in IN cord-009571-mygj2nd4 1276 12 definite definite JJ cord-009571-mygj2nd4 1276 13 SS SS NNP cord-009571-mygj2nd4 1276 14 patients patient NNS cord-009571-mygj2nd4 1276 15 and and CC cord-009571-mygj2nd4 1276 16 97 97 CD cord-009571-mygj2nd4 1276 17 % % NN cord-009571-mygj2nd4 1276 18 specificity specificity NN cord-009571-mygj2nd4 1276 19 in in IN cord-009571-mygj2nd4 1276 20 total total JJ cord-009571-mygj2nd4 1276 21 controls control NNS cord-009571-mygj2nd4 1276 22 , , , cord-009571-mygj2nd4 1276 23 without without IN cord-009571-mygj2nd4 1276 24 using use VBG cord-009571-mygj2nd4 1276 25 exclusions exclusion NNS cord-009571-mygj2nd4 1276 26 . . . cord-009571-mygj2nd4 1277 1 When when WRB cord-009571-mygj2nd4 1277 2 applied apply VBN cord-009571-mygj2nd4 1277 3 to to IN cord-009571-mygj2nd4 1277 4 an an DT cord-009571-mygj2nd4 1277 5 independent independent JJ cord-009571-mygj2nd4 1277 6 rheumatic rheumatic JJ cord-009571-mygj2nd4 1277 7 patient patient NN cord-009571-mygj2nd4 1277 8 _SP cord-009571-mygj2nd4 1277 9 The the DT cord-009571-mygj2nd4 1277 10 course course NN cord-009571-mygj2nd4 1277 11 of of IN cord-009571-mygj2nd4 1277 12 articular articular JJ cord-009571-mygj2nd4 1277 13 involvement involvement NN cord-009571-mygj2nd4 1277 14 in in IN cord-009571-mygj2nd4 1277 15 early early JJ cord-009571-mygj2nd4 1277 16 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1277 17 arthritis arthritis NN cord-009571-mygj2nd4 1277 18 ( ( -LRB- cord-009571-mygj2nd4 1277 19 RA RA NNP cord-009571-mygj2nd4 1277 20 ) ) -RRB- cord-009571-mygj2nd4 1277 21 is be VBZ cord-009571-mygj2nd4 1277 22 variable variable JJ cord-009571-mygj2nd4 1277 23 and and CC cord-009571-mygj2nd4 1277 24 has have VBZ cord-009571-mygj2nd4 1277 25 not not RB cord-009571-mygj2nd4 1277 26 been be VBN cord-009571-mygj2nd4 1277 27 quantitatively quantitatively RB cord-009571-mygj2nd4 1277 28 characterized characterize VBN cord-009571-mygj2nd4 1277 29 . . . cord-009571-mygj2nd4 1278 1 In in IN cord-009571-mygj2nd4 1278 2 a a DT cord-009571-mygj2nd4 1278 3 prospective prospective JJ cord-009571-mygj2nd4 1278 4 study study NN cord-009571-mygj2nd4 1278 5 of of IN cord-009571-mygj2nd4 1278 6 50 50 CD cord-009571-mygj2nd4 1278 7 younger young JJR cord-009571-mygj2nd4 1278 8 adult adult NN cord-009571-mygj2nd4 1278 9 , , , cord-009571-mygj2nd4 1278 10 early early JJ cord-009571-mygj2nd4 1278 11 RA RA NNP cord-009571-mygj2nd4 1278 12 patients patient NNS cord-009571-mygj2nd4 1278 13 ( ( -LRB- cord-009571-mygj2nd4 1278 14 negative negative JJ cord-009571-mygj2nd4 1278 15 for for IN cord-009571-mygj2nd4 1278 16 HLA HLA NNP cord-009571-mygj2nd4 1278 17 - - HYPH cord-009571-mygj2nd4 1278 18 B27 B27 NNP cord-009571-mygj2nd4 1278 19 ) ) -RRB- cord-009571-mygj2nd4 1278 20 , , , cord-009571-mygj2nd4 1278 21 detailed detail VBN cord-009571-mygj2nd4 1278 22 articular articular JJ cord-009571-mygj2nd4 1278 23 , , , cord-009571-mygj2nd4 1278 24 systemic systemic JJ cord-009571-mygj2nd4 1278 25 , , , cord-009571-mygj2nd4 1278 26 laboratory laboratory NN cord-009571-mygj2nd4 1278 27 , , , cord-009571-mygj2nd4 1278 28 and and CC cord-009571-mygj2nd4 1278 29 therapeutic therapeutic JJ cord-009571-mygj2nd4 1278 30 data datum NNS cord-009571-mygj2nd4 1278 31 were be VBD cord-009571-mygj2nd4 1278 32 collected collect VBN cord-009571-mygj2nd4 1278 33 twice twice RB cord-009571-mygj2nd4 1278 34 yearly yearly JJ cord-009571-mygj2nd4 1278 35 for for IN cord-009571-mygj2nd4 1278 36 a a DT cord-009571-mygj2nd4 1278 37 mean mean JJ cord-009571-mygj2nd4 1278 38 followup followup NN cord-009571-mygj2nd4 1278 39 of of IN cord-009571-mygj2nd4 1278 40 over over IN cord-009571-mygj2nd4 1278 41 5 5 CD cord-009571-mygj2nd4 1278 42 years year NNS cord-009571-mygj2nd4 1278 43 . . . cord-009571-mygj2nd4 1279 1 Based base VBN cord-009571-mygj2nd4 1279 2 upon upon IN cord-009571-mygj2nd4 1279 3 the the DT cord-009571-mygj2nd4 1279 4 number number NN cord-009571-mygj2nd4 1279 5 of of IN cord-009571-mygj2nd4 1279 6 joints joint NNS cord-009571-mygj2nd4 1279 7 involved involve VBN cord-009571-mygj2nd4 1279 8 during during IN cord-009571-mygj2nd4 1279 9 followup followup NN cord-009571-mygj2nd4 1279 10 , , , cord-009571-mygj2nd4 1279 11 each each DT cord-009571-mygj2nd4 1279 12 patient patient NN cord-009571-mygj2nd4 1279 13 was be VBD cord-009571-mygj2nd4 1279 14 assigned assign VBN cord-009571-mygj2nd4 1279 15 to to TO cord-009571-mygj2nd4 1279 16 separate separate JJ cord-009571-mygj2nd4 1279 17 pain pain NN cord-009571-mygj2nd4 1279 18 / / SYM cord-009571-mygj2nd4 1279 19 tender tender NN cord-009571-mygj2nd4 1279 20 ( ( -LRB- cord-009571-mygj2nd4 1279 21 P p NN cord-009571-mygj2nd4 1279 22 / / SYM cord-009571-mygj2nd4 1279 23 T T NNP cord-009571-mygj2nd4 1279 24 ) ) -RRB- cord-009571-mygj2nd4 1279 25 and and CC cord-009571-mygj2nd4 1279 26 swelling swell VBG cord-009571-mygj2nd4 1279 27 ( ( -LRB- cord-009571-mygj2nd4 1279 28 SW SW NNP cord-009571-mygj2nd4 1279 29 ) ) -RRB- cord-009571-mygj2nd4 1279 30 articular articular JJ cord-009571-mygj2nd4 1279 31 course course NN cord-009571-mygj2nd4 1279 32 patterns pattern NNS cord-009571-mygj2nd4 1279 33 . . . cord-009571-mygj2nd4 1280 1 Monocyclic monocyclic JJ cord-009571-mygj2nd4 1280 2 pattern pattern NN cord-009571-mygj2nd4 1280 3 was be VBD cord-009571-mygj2nd4 1280 4 defined define VBN cord-009571-mygj2nd4 1280 5 as as IN cord-009571-mygj2nd4 1280 6 one one CD cord-009571-mygj2nd4 1280 7 cycle cycle NN cord-009571-mygj2nd4 1280 8 of of IN cord-009571-mygj2nd4 1280 9 documented document VBN cord-009571-mygj2nd4 1280 10 arthritis arthritis NN cord-009571-mygj2nd4 1280 11 with with IN cord-009571-mygj2nd4 1280 12 articular articular JJ cord-009571-mygj2nd4 1280 13 remission remission NN cord-009571-mygj2nd4 1280 14 observed observe VBD cord-009571-mygj2nd4 1280 15 for for IN cord-009571-mygj2nd4 1280 16 at at RB cord-009571-mygj2nd4 1280 17 least least RBS cord-009571-mygj2nd4 1280 18 1 1 CD cord-009571-mygj2nd4 1280 19 year year NN cord-009571-mygj2nd4 1280 20 ; ; , cord-009571-mygj2nd4 1280 21 intermittent intermittent JJ cord-009571-mygj2nd4 1280 22 as as IN cord-009571-mygj2nd4 1280 23 two two CD cord-009571-mygj2nd4 1280 24 or or CC cord-009571-mygj2nd4 1280 25 more more JJR cord-009571-mygj2nd4 1280 26 arthritis arthritis NN cord-009571-mygj2nd4 1280 27 cycles cycle NNS cord-009571-mygj2nd4 1280 28 , , , cord-009571-mygj2nd4 1280 29 each each DT cord-009571-mygj2nd4 1280 30 separated separate VBN cord-009571-mygj2nd4 1280 31 by by IN cord-009571-mygj2nd4 1280 32 joint joint JJ cord-009571-mygj2nd4 1280 33 remission remission NN cord-009571-mygj2nd4 1280 34 of of IN cord-009571-mygj2nd4 1280 35 at at RB cord-009571-mygj2nd4 1280 36 least least RBS cord-009571-mygj2nd4 1280 37 6 6 CD cord-009571-mygj2nd4 1280 38 months month NNS cord-009571-mygj2nd4 1280 39 ; ; : cord-009571-mygj2nd4 1280 40 continuing continue VBG cord-009571-mygj2nd4 1280 41 as as RB cord-009571-mygj2nd4 1280 42 continuous continuous JJ cord-009571-mygj2nd4 1280 43 joint joint JJ cord-009571-mygj2nd4 1280 44 involvement involvement NN cord-009571-mygj2nd4 1280 45 but but CC cord-009571-mygj2nd4 1280 46 without without IN cord-009571-mygj2nd4 1280 47 persistent persistent JJ cord-009571-mygj2nd4 1280 48 progression progression NN cord-009571-mygj2nd4 1280 49 ; ; : cord-009571-mygj2nd4 1280 50 and and CC cord-009571-mygj2nd4 1280 51 progressive progressive JJ cord-009571-mygj2nd4 1280 52 as as IN cord-009571-mygj2nd4 1280 53 continued continue VBN cord-009571-mygj2nd4 1280 54 progressive progressive JJ cord-009571-mygj2nd4 1280 55 involvement involvement NN cord-009571-mygj2nd4 1280 56 . . . cord-009571-mygj2nd4 1281 1 The the DT cord-009571-mygj2nd4 1281 2 table table NN cord-009571-mygj2nd4 1281 3 shows show VBZ cord-009571-mygj2nd4 1281 4 numbers number NNS cord-009571-mygj2nd4 1281 5 of of IN cord-009571-mygj2nd4 1281 6 cases case NNS cord-009571-mygj2nd4 1281 7 in in IN cord-009571-mygj2nd4 1281 8 each each DT cord-009571-mygj2nd4 1281 9 pattern pattern NN cord-009571-mygj2nd4 1281 10 , , , cord-009571-mygj2nd4 1281 11 mean mean JJ cord-009571-mygj2nd4 1281 12 numbers number NNS cord-009571-mygj2nd4 1281 13 of of IN cord-009571-mygj2nd4 1281 14 joints joint NNS cord-009571-mygj2nd4 1281 15 involved involve VBN cord-009571-mygj2nd4 1281 16 at at IN cord-009571-mygj2nd4 1281 17 entry entry NN cord-009571-mygj2nd4 1281 18 , , , cord-009571-mygj2nd4 1281 19 and and CC cord-009571-mygj2nd4 1281 20 the the DT cord-009571-mygj2nd4 1281 21 mean mean JJ cord-009571-mygj2nd4 1281 22 annual annual JJ cord-009571-mygj2nd4 1281 23 change change NN cord-009571-mygj2nd4 1281 24 ( ( -LRB- cord-009571-mygj2nd4 1281 25 A a NN cord-009571-mygj2nd4 1281 26 ) ) -RRB- cord-009571-mygj2nd4 1281 27 in in IN cord-009571-mygj2nd4 1281 28 numbers number NNS cord-009571-mygj2nd4 1281 29 of of IN cord-009571-mygj2nd4 1281 30 joints joint NNS cord-009571-mygj2nd4 1281 31 involved involve VBN cord-009571-mygj2nd4 1281 32 during during IN cord-009571-mygj2nd4 1281 33 followup followup NN cord-009571-mygj2nd4 1281 34 , , , cord-009571-mygj2nd4 1281 35 determined determine VBN cord-009571-mygj2nd4 1281 36 by by IN cord-009571-mygj2nd4 1281 37 regression regression NN cord-009571-mygj2nd4 1281 38 analysis analysis NN cord-009571-mygj2nd4 1281 39 . . . cord-009571-mygj2nd4 1282 1 Monocyclic monocyclic JJ cord-009571-mygj2nd4 1282 2 groups group NNS cord-009571-mygj2nd4 1282 3 included include VBD cord-009571-mygj2nd4 1282 4 significantly significantly RB cord-009571-mygj2nd4 1282 5 more more JJR cord-009571-mygj2nd4 1282 6 males male NNS cord-009571-mygj2nd4 1282 7 ( ( -LRB- cord-009571-mygj2nd4 1282 8 P p NN cord-009571-mygj2nd4 1282 9 / / SYM cord-009571-mygj2nd4 1282 10 T T NNP cord-009571-mygj2nd4 1282 11 , , , cord-009571-mygj2nd4 1282 12 P p NN cord-009571-mygj2nd4 1282 13 < < XX cord-009571-mygj2nd4 1282 14 0.05 0.05 CD cord-009571-mygj2nd4 1282 15 ; ; : cord-009571-mygj2nd4 1282 16 SW SW NNP cord-009571-mygj2nd4 1282 17 , , , cord-009571-mygj2nd4 1282 18 P p NN cord-009571-mygj2nd4 1282 19 < < XX cord-009571-mygj2nd4 1282 20 0.001 0.001 CD cord-009571-mygj2nd4 1282 21 ) ) -RRB- cord-009571-mygj2nd4 1282 22 , , , cord-009571-mygj2nd4 1282 23 and and CC cord-009571-mygj2nd4 1282 24 seronegative seronegative JJ cord-009571-mygj2nd4 1282 25 cases case NNS cord-009571-mygj2nd4 1283 1 ( ( -LRB- cord-009571-mygj2nd4 1283 2 P p NN cord-009571-mygj2nd4 1283 3 / / SYM cord-009571-mygj2nd4 1283 4 T T NNP cord-009571-mygj2nd4 1283 5 , , , cord-009571-mygj2nd4 1283 6 P p NN cord-009571-mygj2nd4 1283 7 < < XX cord-009571-mygj2nd4 1283 8 0.05 0.05 CD cord-009571-mygj2nd4 1283 9 ; ; : cord-009571-mygj2nd4 1283 10 SW SW NNP cord-009571-mygj2nd4 1283 11 , , , cord-009571-mygj2nd4 1283 12 P p NN cord-009571-mygj2nd4 1283 13 < < XX cord-009571-mygj2nd4 1283 14 0.01 0.01 CD cord-009571-mygj2nd4 1283 15 ) ) -RRB- cord-009571-mygj2nd4 1283 16 . . . cord-009571-mygj2nd4 1284 1 Only only RB cord-009571-mygj2nd4 1284 2 one one CD cord-009571-mygj2nd4 1284 3 woman woman NN cord-009571-mygj2nd4 1284 4 experienced experience VBD cord-009571-mygj2nd4 1284 5 complete complete JJ cord-009571-mygj2nd4 1284 6 articular articular JJ cord-009571-mygj2nd4 1284 7 remission remission NN cord-009571-mygj2nd4 1284 8 while while IN cord-009571-mygj2nd4 1284 9 progressive progressive JJ cord-009571-mygj2nd4 1284 10 swelling swelling NN cord-009571-mygj2nd4 1284 11 occurred occur VBD cord-009571-mygj2nd4 1284 12 in in IN cord-009571-mygj2nd4 1284 13 only only RB cord-009571-mygj2nd4 1284 14 2 2 CD cord-009571-mygj2nd4 1284 15 cases case NNS cord-009571-mygj2nd4 1284 16 . . . cord-009571-mygj2nd4 1285 1 Entry entry NN cord-009571-mygj2nd4 1285 2 joint joint JJ cord-009571-mygj2nd4 1285 3 involvement involvement NN cord-009571-mygj2nd4 1285 4 correlated correlate VBN cord-009571-mygj2nd4 1285 5 with with IN cord-009571-mygj2nd4 1285 6 subsequent subsequent JJ cord-009571-mygj2nd4 1285 7 P p NN cord-009571-mygj2nd4 1285 8 / / SYM cord-009571-mygj2nd4 1285 9 T T NNP cord-009571-mygj2nd4 1285 10 and and CC cord-009571-mygj2nd4 1285 11 SW SW NNP cord-009571-mygj2nd4 1285 12 articular articular JJ cord-009571-mygj2nd4 1285 13 patterns pattern NNS cord-009571-mygj2nd4 1285 14 ( ( -LRB- cord-009571-mygj2nd4 1285 15 P p NN cord-009571-mygj2nd4 1285 16 < < XX cord-009571-mygj2nd4 1285 17 0.01 0.01 CD cord-009571-mygj2nd4 1285 18 and and CC cord-009571-mygj2nd4 1285 19 P p NN cord-009571-mygj2nd4 1285 20 < < XX cord-009571-mygj2nd4 1285 21 0.05 0.05 CD cord-009571-mygj2nd4 1285 22 , , , cord-009571-mygj2nd4 1285 23 respectively respectively RB cord-009571-mygj2nd4 1285 24 ) ) -RRB- cord-009571-mygj2nd4 1285 25 . . . cord-009571-mygj2nd4 1286 1 Cross cross JJ cord-009571-mygj2nd4 1286 2 - - JJ cord-009571-mygj2nd4 1286 3 sectional sectional JJ cord-009571-mygj2nd4 1286 4 analysis analysis NN cord-009571-mygj2nd4 1286 5 of of IN cord-009571-mygj2nd4 1286 6 the the DT cord-009571-mygj2nd4 1286 7 numbers number NNS cord-009571-mygj2nd4 1286 8 of of IN cord-009571-mygj2nd4 1286 9 joints joint NNS cord-009571-mygj2nd4 1286 10 involved involve VBN cord-009571-mygj2nd4 1286 11 at at IN cord-009571-mygj2nd4 1286 12 each each DT cord-009571-mygj2nd4 1286 13 protocol protocol NN cord-009571-mygj2nd4 1286 14 exam exam NN cord-009571-mygj2nd4 1286 15 and and CC cord-009571-mygj2nd4 1286 16 longitudinal longitudinal JJ cord-009571-mygj2nd4 1286 17 analysis analysis NN cord-009571-mygj2nd4 1286 18 of of IN cord-009571-mygj2nd4 1286 19 regression regression NN cord-009571-mygj2nd4 1286 20 slopes slope NNS cord-009571-mygj2nd4 1286 21 of of IN cord-009571-mygj2nd4 1286 22 individual individual JJ cord-009571-mygj2nd4 1286 23 patient patient JJ cord-009571-mygj2nd4 1286 24 joint joint JJ cord-009571-mygj2nd4 1286 25 involvement involvement NN cord-009571-mygj2nd4 1287 1 both both DT cord-009571-mygj2nd4 1287 2 indicated indicate VBD cord-009571-mygj2nd4 1287 3 trimodal trimodal JJ cord-009571-mygj2nd4 1287 4 distributions distribution NNS cord-009571-mygj2nd4 1287 5 : : : cord-009571-mygj2nd4 1287 6 monocyclic monocyclic JJ cord-009571-mygj2nd4 1287 7 ; ; : cord-009571-mygj2nd4 1287 8 chronic chronic JJ cord-009571-mygj2nd4 1287 9 ( ( -LRB- cord-009571-mygj2nd4 1287 10 ie ie FW cord-009571-mygj2nd4 1287 11 , , , cord-009571-mygj2nd4 1287 12 combined combine VBN cord-009571-mygj2nd4 1287 13 intermittent intermittent JJ cord-009571-mygj2nd4 1287 14 and and CC cord-009571-mygj2nd4 1287 15 continuing continue VBG cord-009571-mygj2nd4 1287 16 groups group NNS cord-009571-mygj2nd4 1287 17 ) ) -RRB- cord-009571-mygj2nd4 1287 18 , , , cord-009571-mygj2nd4 1287 19 and and CC cord-009571-mygj2nd4 1287 20 progressive progressive JJ cord-009571-mygj2nd4 1287 21 patterns pattern NNS cord-009571-mygj2nd4 1287 22 , , , cord-009571-mygj2nd4 1287 23 which which WDT cord-009571-mygj2nd4 1287 24 were be VBD cord-009571-mygj2nd4 1287 25 independent independent JJ cord-009571-mygj2nd4 1287 26 of of IN cord-009571-mygj2nd4 1287 27 therapy therapy NN cord-009571-mygj2nd4 1287 28 . . . cord-009571-mygj2nd4 1288 1 The the DT cord-009571-mygj2nd4 1288 2 data datum NNS cord-009571-mygj2nd4 1288 3 provide provide VBP cord-009571-mygj2nd4 1288 4 quantitative quantitative JJ cord-009571-mygj2nd4 1288 5 evidence evidence NN cord-009571-mygj2nd4 1288 6 for for IN cord-009571-mygj2nd4 1288 7 monocyclic monocyclic NNP cord-009571-mygj2nd4 1288 8 , , , cord-009571-mygj2nd4 1288 9 chronic chronic JJ cord-009571-mygj2nd4 1288 10 , , , cord-009571-mygj2nd4 1288 11 and and CC cord-009571-mygj2nd4 1288 12 progressive progressive JJ cord-009571-mygj2nd4 1288 13 articular articular JJ cord-009571-mygj2nd4 1288 14 course course NN cord-009571-mygj2nd4 1288 15 patterns pattern NNS cord-009571-mygj2nd4 1288 16 in in IN cord-009571-mygj2nd4 1288 17 early early JJ cord-009571-mygj2nd4 1288 18 RA RA NNP cord-009571-mygj2nd4 1288 19 , , , cord-009571-mygj2nd4 1288 20 with with IN cord-009571-mygj2nd4 1288 21 identification identification NN cord-009571-mygj2nd4 1288 22 of of IN cord-009571-mygj2nd4 1288 23 significant significant JJ cord-009571-mygj2nd4 1288 24 sex sex NN cord-009571-mygj2nd4 1288 25 and and CC cord-009571-mygj2nd4 1288 26 clinical clinical JJ cord-009571-mygj2nd4 1288 27 correlates correlate NNS cord-009571-mygj2nd4 1288 28 . . . cord-009571-mygj2nd4 1288 29 _SP cord-009571-mygj2nd4 1289 1 In in IN cord-009571-mygj2nd4 1289 2 some some DT cord-009571-mygj2nd4 1289 3 postmortem postmortem JJ cord-009571-mygj2nd4 1289 4 cases case NNS cord-009571-mygj2nd4 1289 5 of of IN cord-009571-mygj2nd4 1289 6 systemic systemic JJ cord-009571-mygj2nd4 1289 7 lupus lupus NN cord-009571-mygj2nd4 1289 8 erythematosus erythematosus NN cord-009571-mygj2nd4 1289 9 ( ( -LRB- cord-009571-mygj2nd4 1289 10 SLE SLE NNP cord-009571-mygj2nd4 1289 11 ) ) -RRB- cord-009571-mygj2nd4 1289 12 associated associate VBN cord-009571-mygj2nd4 1289 13 with with IN cord-009571-mygj2nd4 1289 14 diffuse diffuse JJ cord-009571-mygj2nd4 1289 15 proliferative proliferative JJ cord-009571-mygj2nd4 1289 16 glomerulonephritis glomerulonephritis NN cord-009571-mygj2nd4 1289 17 ( ( -LRB- cord-009571-mygj2nd4 1289 18 DPGN DPGN NNP cord-009571-mygj2nd4 1289 19 ) ) -RRB- cord-009571-mygj2nd4 1289 20 , , , cord-009571-mygj2nd4 1289 21 an an DT cord-009571-mygj2nd4 1289 22 antigen antigen NN cord-009571-mygj2nd4 1289 23 related relate VBN cord-009571-mygj2nd4 1289 24 to to IN cord-009571-mygj2nd4 1289 25 mammalian mammalian JJ cord-009571-mygj2nd4 1289 26 type type NN cord-009571-mygj2nd4 1289 27 C C NNP cord-009571-mygj2nd4 1289 28 RNA RNA NNP cord-009571-mygj2nd4 1289 29 viral viral JJ cord-009571-mygj2nd4 1289 30 core core NN cord-009571-mygj2nd4 1289 31 ( ( -LRB- cord-009571-mygj2nd4 1289 32 p30 p30 NN cord-009571-mygj2nd4 1289 33 ) ) -RRB- cord-009571-mygj2nd4 1289 34 protein protein NN cord-009571-mygj2nd4 1289 35 is be VBZ cord-009571-mygj2nd4 1289 36 deposited deposit VBN cord-009571-mygj2nd4 1289 37 in in IN cord-009571-mygj2nd4 1289 38 the the DT cord-009571-mygj2nd4 1289 39 glomerular glomerular JJ cord-009571-mygj2nd4 1289 40 lesions lesion NNS cord-009571-mygj2nd4 1289 41 in in IN cord-009571-mygj2nd4 1289 42 an an DT cord-009571-mygj2nd4 1289 43 immune immune JJ cord-009571-mygj2nd4 1289 44 complex complex JJ cord-009571-mygj2nd4 1289 45 pattern pattern NN cord-009571-mygj2nd4 1289 46 ( ( -LRB- cord-009571-mygj2nd4 1289 47 Proc Proc NNP cord-009571-mygj2nd4 1289 48 Natl Natl NNP cord-009571-mygj2nd4 1289 49 Acad Acad NNP cord-009571-mygj2nd4 1289 50 Sci Sci NNP cord-009571-mygj2nd4 1289 51 73:233 73:233 CD cord-009571-mygj2nd4 1289 52 , , , cord-009571-mygj2nd4 1289 53 1976 1976 CD cord-009571-mygj2nd4 1289 54 ) ) -RRB- cord-009571-mygj2nd4 1289 55 . . . cord-009571-mygj2nd4 1290 1 Now now RB cord-009571-mygj2nd4 1290 2 an an DT cord-009571-mygj2nd4 1290 3 attempt attempt NN cord-009571-mygj2nd4 1290 4 is be VBZ cord-009571-mygj2nd4 1290 5 made make VBN cord-009571-mygj2nd4 1290 6 to to TO cord-009571-mygj2nd4 1290 7 support support VB cord-009571-mygj2nd4 1290 8 this this DT cord-009571-mygj2nd4 1290 9 finding finding NN cord-009571-mygj2nd4 1290 10 by by IN cord-009571-mygj2nd4 1290 11 examining examine VBG cord-009571-mygj2nd4 1290 12 the the DT cord-009571-mygj2nd4 1290 13 glomerular glomerular JJ cord-009571-mygj2nd4 1290 14 immune immune JJ cord-009571-mygj2nd4 1290 15 deposits deposit NNS cord-009571-mygj2nd4 1290 16 in in IN cord-009571-mygj2nd4 1290 17 SLE SLE NNP cord-009571-mygj2nd4 1290 18 - - HYPH cord-009571-mygj2nd4 1290 19 DPGN DPGN NNP cord-009571-mygj2nd4 1290 20 for for IN cord-009571-mygj2nd4 1290 21 evidence evidence NN cord-009571-mygj2nd4 1290 22 of of IN cord-009571-mygj2nd4 1290 23 type type NN cord-009571-mygj2nd4 1290 24 C C NNP cord-009571-mygj2nd4 1290 25 virus virus NN cord-009571-mygj2nd4 1290 26 antibody antibody NN cord-009571-mygj2nd4 1290 27 . . . cord-009571-mygj2nd4 1291 1 Human human JJ cord-009571-mygj2nd4 1291 2 immunoglobulins immunoglobulin NNS cord-009571-mygj2nd4 1291 3 ( ( -LRB- cord-009571-mygj2nd4 1291 4 Igs Igs NNP cord-009571-mygj2nd4 1291 5 ) ) -RRB- cord-009571-mygj2nd4 1291 6 were be VBD cord-009571-mygj2nd4 1291 7 eluted elute VBN cord-009571-mygj2nd4 1291 8 from from IN cord-009571-mygj2nd4 1291 9 the the DT cord-009571-mygj2nd4 1291 10 glomerular glomerular JJ cord-009571-mygj2nd4 1291 11 immune immune JJ cord-009571-mygj2nd4 1291 12 deposits deposit NNS cord-009571-mygj2nd4 1291 13 in in IN cord-009571-mygj2nd4 1291 14 two two CD cord-009571-mygj2nd4 1291 15 fractions fraction NNS cord-009571-mygj2nd4 1291 16 by by IN cord-009571-mygj2nd4 1291 17 sequential sequential JJ cord-009571-mygj2nd4 1291 18 treatment treatment NN cord-009571-mygj2nd4 1291 19 with with IN cord-009571-mygj2nd4 1291 20 DNase DNase NNP cord-009571-mygj2nd4 1291 21 to to TO cord-009571-mygj2nd4 1291 22 elute elute VB cord-009571-mygj2nd4 1291 23 anti anti JJ cord-009571-mygj2nd4 1291 24 - - JJ cord-009571-mygj2nd4 1291 25 DNA dna JJ cord-009571-mygj2nd4 1291 26 antibodies antibody NNS cord-009571-mygj2nd4 1291 27 , , , cord-009571-mygj2nd4 1291 28 followed follow VBN cord-009571-mygj2nd4 1291 29 by by IN cord-009571-mygj2nd4 1291 30 acid acid JJ cord-009571-mygj2nd4 1291 31 buffer buffer NN cord-009571-mygj2nd4 1291 32 to to TO cord-009571-mygj2nd4 1291 33 elute elute VB cord-009571-mygj2nd4 1291 34 remaining remain VBG cord-009571-mygj2nd4 1291 35 antibodies antibody NNS cord-009571-mygj2nd4 1291 36 . . . cord-009571-mygj2nd4 1292 1 The the DT cord-009571-mygj2nd4 1292 2 eluted eluted JJ cord-009571-mygj2nd4 1292 3 Igs Igs NNP cord-009571-mygj2nd4 1292 4 were be VBD cord-009571-mygj2nd4 1292 5 then then RB cord-009571-mygj2nd4 1292 6 assayed assay VBN cord-009571-mygj2nd4 1292 7 by by IN cord-009571-mygj2nd4 1292 8 a a DT cord-009571-mygj2nd4 1292 9 sensitive sensitive JJ cord-009571-mygj2nd4 1292 10 , , , cord-009571-mygj2nd4 1292 11 specific specific JJ cord-009571-mygj2nd4 1292 12 , , , cord-009571-mygj2nd4 1292 13 and and CC cord-009571-mygj2nd4 1292 14 quantitative quantitative JJ cord-009571-mygj2nd4 1292 15 enzymoimmunoassay enzymoimmunoassay NN cord-009571-mygj2nd4 1292 16 , , , cord-009571-mygj2nd4 1292 17 which which WDT cord-009571-mygj2nd4 1292 18 compares compare VBZ cord-009571-mygj2nd4 1292 19 favorably favorably RB cord-009571-mygj2nd4 1292 20 with with IN cord-009571-mygj2nd4 1292 21 radioimmunoassay radioimmunoassay JJ cord-009571-mygj2nd4 1292 22 , , , cord-009571-mygj2nd4 1292 23 for for IN cord-009571-mygj2nd4 1292 24 the the DT cord-009571-mygj2nd4 1292 25 detection detection NN cord-009571-mygj2nd4 1292 26 and and CC cord-009571-mygj2nd4 1292 27 measurement measurement NN cord-009571-mygj2nd4 1292 28 of of IN cord-009571-mygj2nd4 1292 29 anti anti JJ cord-009571-mygj2nd4 1292 30 - - JJ cord-009571-mygj2nd4 1292 31 p30 p30 NNP cord-009571-mygj2nd4 1292 32 antibody antibody NN cord-009571-mygj2nd4 1292 33 against against IN cord-009571-mygj2nd4 1292 34 purified purify VBN cord-009571-mygj2nd4 1292 35 p30 p30 NN cord-009571-mygj2nd4 1292 36 proteins protein NNS cord-009571-mygj2nd4 1292 37 of of IN cord-009571-mygj2nd4 1292 38 the the DT cord-009571-mygj2nd4 1292 39 four four CD cord-009571-mygj2nd4 1292 40 chief chief JJ cord-009571-mygj2nd4 1292 41 groups group NNS cord-009571-mygj2nd4 1292 42 of of IN cord-009571-mygj2nd4 1292 43 mammalian mammalian JJ cord-009571-mygj2nd4 1292 44 type type NN cord-009571-mygj2nd4 1292 45 C c NN cord-009571-mygj2nd4 1292 46 viruses virus NNS cord-009571-mygj2nd4 1292 47 : : : cord-009571-mygj2nd4 1292 48 murine murine JJ cord-009571-mygj2nd4 1292 49 , , , cord-009571-mygj2nd4 1292 50 feline feline JJ cord-009571-mygj2nd4 1292 51 , , , cord-009571-mygj2nd4 1292 52 endogenous endogenous JJ cord-009571-mygj2nd4 1292 53 feline feline JJ cord-009571-mygj2nd4 1292 54 RD RD NNP cord-009571-mygj2nd4 1292 55 - - : cord-009571-mygj2nd4 1292 56 I I NNP cord-009571-mygj2nd4 1292 57 14 14 CD cord-009571-mygj2nd4 1292 58 / / SYM cord-009571-mygj2nd4 1292 59 endogenous endogenous JJ cord-009571-mygj2nd4 1292 60 primate primate NN cord-009571-mygj2nd4 1292 61 , , , cord-009571-mygj2nd4 1292 62 and and CC cord-009571-mygj2nd4 1292 63 simian simian JJ cord-009571-mygj2nd4 1292 64 sarcoma sarcoma NN cord-009571-mygj2nd4 1292 65 virus virus NN cord-009571-mygj2nd4 1292 66 type type NN cord-009571-mygj2nd4 1292 67 I -PRON- PRP cord-009571-mygj2nd4 1292 68 ( ( -LRB- cord-009571-mygj2nd4 1292 69 SSV SSV NNP cord-009571-mygj2nd4 1292 70 - - HYPH cord-009571-mygj2nd4 1292 71 I)/infectious i)/infectious JJ cord-009571-mygj2nd4 1292 72 primate primate JJ cord-009571-mygj2nd4 1292 73 virus virus NN cord-009571-mygj2nd4 1292 74 groups group NNS cord-009571-mygj2nd4 1292 75 . . . cord-009571-mygj2nd4 1293 1 Human Human NNP cord-009571-mygj2nd4 1293 2 Igs Igs NNP cord-009571-mygj2nd4 1293 3 which which WDT cord-009571-mygj2nd4 1293 4 showed show VBD cord-009571-mygj2nd4 1293 5 specific specific JJ cord-009571-mygj2nd4 1293 6 anti anti JJ cord-009571-mygj2nd4 1293 7 - - JJ cord-009571-mygj2nd4 1293 8 p30 p30 NNP cord-009571-mygj2nd4 1293 9 antibody antibody NN cord-009571-mygj2nd4 1293 10 activity activity NN cord-009571-mygj2nd4 1293 11 , , , cord-009571-mygj2nd4 1293 12 particularly particularly RB cord-009571-mygj2nd4 1293 13 against against IN cord-009571-mygj2nd4 1293 14 p30 p30 NNP cord-009571-mygj2nd4 1293 15 antigen antigen NNP cord-009571-mygj2nd4 1293 16 of of IN cord-009571-mygj2nd4 1293 17 the the DT cord-009571-mygj2nd4 1293 18 RD RD NNP cord-009571-mygj2nd4 1293 19 - - : cord-009571-mygj2nd4 1293 20 I I NNP cord-009571-mygj2nd4 1293 21 14 14 CD cord-009571-mygj2nd4 1293 22 virus virus NN cord-009571-mygj2nd4 1293 23 group group NN cord-009571-mygj2nd4 1293 24 and and CC cord-009571-mygj2nd4 1293 25 to to IN cord-009571-mygj2nd4 1293 26 lesser less JJR cord-009571-mygj2nd4 1293 27 extent extent NN cord-009571-mygj2nd4 1293 28 against against IN cord-009571-mygj2nd4 1293 29 p30 p30 NNP cord-009571-mygj2nd4 1293 30 antigen antigen NNP cord-009571-mygj2nd4 1293 31 of of IN cord-009571-mygj2nd4 1293 32 the the DT cord-009571-mygj2nd4 1293 33 murine murine JJ cord-009571-mygj2nd4 1293 34 and and CC cord-009571-mygj2nd4 1293 35 SSV SSV NNP cord-009571-mygj2nd4 1293 36 - - HYPH cord-009571-mygj2nd4 1293 37 I -PRON- PRP cord-009571-mygj2nd4 1293 38 virus virus NN cord-009571-mygj2nd4 1293 39 groups group NNS cord-009571-mygj2nd4 1293 40 , , , cord-009571-mygj2nd4 1293 41 was be VBD cord-009571-mygj2nd4 1293 42 eluted elute VBN cord-009571-mygj2nd4 1293 43 by by IN cord-009571-mygj2nd4 1293 44 acid acid JJ cord-009571-mygj2nd4 1293 45 buffer buffer NN cord-009571-mygj2nd4 1293 46 from from IN cord-009571-mygj2nd4 1293 47 the the DT cord-009571-mygj2nd4 1293 48 glomerular glomerular JJ cord-009571-mygj2nd4 1293 49 immune immune JJ cord-009571-mygj2nd4 1293 50 deposits deposit NNS cord-009571-mygj2nd4 1293 51 in in IN cord-009571-mygj2nd4 1293 52 two two CD cord-009571-mygj2nd4 1293 53 cases case NNS cord-009571-mygj2nd4 1293 54 of of IN cord-009571-mygj2nd4 1293 55 SLE SLE NNP cord-009571-mygj2nd4 1293 56 - - HYPH cord-009571-mygj2nd4 1293 57 DPGN DPGN NNP cord-009571-mygj2nd4 1293 58 that that WDT cord-009571-mygj2nd4 1293 59 were be VBD cord-009571-mygj2nd4 1293 60 known know VBN cord-009571-mygj2nd4 1293 61 from from IN cord-009571-mygj2nd4 1293 62 previous previous JJ cord-009571-mygj2nd4 1293 63 study study NN cord-009571-mygj2nd4 1293 64 to to TO cord-009571-mygj2nd4 1293 65 contain contain VB cord-009571-mygj2nd4 1293 66 deposits deposit NNS cord-009571-mygj2nd4 1293 67 of of IN cord-009571-mygj2nd4 1293 68 viral viral JJ cord-009571-mygj2nd4 1293 69 p30-related p30-relate VBN cord-009571-mygj2nd4 1293 70 antigen antigen NN cord-009571-mygj2nd4 1293 71 in in IN cord-009571-mygj2nd4 1293 72 the the DT cord-009571-mygj2nd4 1293 73 same same JJ cord-009571-mygj2nd4 1293 74 tissue tissue NN cord-009571-mygj2nd4 1293 75 lesions lesion NNS cord-009571-mygj2nd4 1293 76 . . . cord-009571-mygj2nd4 1294 1 These these DT cord-009571-mygj2nd4 1294 2 findings finding NNS cord-009571-mygj2nd4 1294 3 support support VBP cord-009571-mygj2nd4 1294 4 the the DT cord-009571-mygj2nd4 1294 5 hypothesis hypothesis NN cord-009571-mygj2nd4 1294 6 , , , cord-009571-mygj2nd4 1294 7 stemming stem VBG cord-009571-mygj2nd4 1294 8 from from IN cord-009571-mygj2nd4 1294 9 studies study NNS cord-009571-mygj2nd4 1294 10 of of IN cord-009571-mygj2nd4 1294 11 the the DT cord-009571-mygj2nd4 1294 12 New New NNP cord-009571-mygj2nd4 1294 13 Zealand Zealand NNP cord-009571-mygj2nd4 1294 14 mouse mouse NN cord-009571-mygj2nd4 1294 15 model model NN cord-009571-mygj2nd4 1294 16 of of IN cord-009571-mygj2nd4 1294 17 SLE SLE NNP cord-009571-mygj2nd4 1294 18 , , , cord-009571-mygj2nd4 1294 19 that that WDT cord-009571-mygj2nd4 1294 20 subinfectious subinfectious JJ cord-009571-mygj2nd4 1294 21 antigenic antigenic JJ cord-009571-mygj2nd4 1294 22 expression expression NN cord-009571-mygj2nd4 1294 23 of of IN cord-009571-mygj2nd4 1294 24 a a DT cord-009571-mygj2nd4 1294 25 type type NN cord-009571-mygj2nd4 1294 26 C c NN cord-009571-mygj2nd4 1294 27 virus virus NN cord-009571-mygj2nd4 1294 28 is be VBZ cord-009571-mygj2nd4 1294 29 involved involve VBN cord-009571-mygj2nd4 1294 30 in in IN cord-009571-mygj2nd4 1294 31 the the DT cord-009571-mygj2nd4 1294 32 pathogenesis pathogenesis NN cord-009571-mygj2nd4 1294 33 of of IN cord-009571-mygj2nd4 1294 34 DPGN DPGN NNP cord-009571-mygj2nd4 1294 35 associated associate VBN cord-009571-mygj2nd4 1294 36 with with IN cord-009571-mygj2nd4 1294 37 SLE SLE NNP cord-009571-mygj2nd4 1294 38 . . . cord-009571-mygj2nd4 1295 1 ( ( -LRB- cord-009571-mygj2nd4 1295 2 This this DT cord-009571-mygj2nd4 1295 3 work work NN cord-009571-mygj2nd4 1295 4 was be VBD cord-009571-mygj2nd4 1295 5 supported support VBN cord-009571-mygj2nd4 1295 6 by by IN cord-009571-mygj2nd4 1295 7 NCI NCI NNP cord-009571-mygj2nd4 1295 8 , , , cord-009571-mygj2nd4 1295 9 DHEW DHEW NNP cord-009571-mygj2nd4 1295 10 grant grant VBP cord-009571-mygj2nd4 1295 11 no no NN cord-009571-mygj2nd4 1295 12 . . . cord-009571-mygj2nd4 1296 1 Male Male NNP cord-009571-mygj2nd4 1296 2 B B NNP cord-009571-mygj2nd4 1296 3 / / SYM cord-009571-mygj2nd4 1296 4 W w NN cord-009571-mygj2nd4 1296 5 mice mouse NNS cord-009571-mygj2nd4 1296 6 generally generally RB cord-009571-mygj2nd4 1296 7 die die VBP cord-009571-mygj2nd4 1296 8 after after IN cord-009571-mygj2nd4 1296 9 one one CD cord-009571-mygj2nd4 1296 10 year year NN cord-009571-mygj2nd4 1296 11 of of IN cord-009571-mygj2nd4 1296 12 age age NN cord-009571-mygj2nd4 1296 13 with with IN cord-009571-mygj2nd4 1296 14 lupus lupus NN cord-009571-mygj2nd4 1296 15 nephritis nephritis NN cord-009571-mygj2nd4 1296 16 and/or and/or CC cord-009571-mygj2nd4 1296 17 lymphoid lymphoid JJ cord-009571-mygj2nd4 1296 18 malignancy malignancy NN cord-009571-mygj2nd4 1296 19 . . . cord-009571-mygj2nd4 1297 1 These these DT cord-009571-mygj2nd4 1297 2 mice mouse NNS cord-009571-mygj2nd4 1297 3 gradually gradually RB cord-009571-mygj2nd4 1297 4 develop develop VBP cord-009571-mygj2nd4 1297 5 a a DT cord-009571-mygj2nd4 1297 6 severe severe JJ cord-009571-mygj2nd4 1297 7 depression depression NN cord-009571-mygj2nd4 1297 8 of of IN cord-009571-mygj2nd4 1297 9 cell cell NN cord-009571-mygj2nd4 1297 10 - - HYPH cord-009571-mygj2nd4 1297 11 mediated mediate VBN cord-009571-mygj2nd4 1297 12 immunity immunity NN cord-009571-mygj2nd4 1297 13 which which WDT cord-009571-mygj2nd4 1297 14 may may MD cord-009571-mygj2nd4 1297 15 contribute contribute VB cord-009571-mygj2nd4 1297 16 to to IN cord-009571-mygj2nd4 1297 17 the the DT cord-009571-mygj2nd4 1297 18 subsequent subsequent JJ cord-009571-mygj2nd4 1297 19 fatal fatal JJ cord-009571-mygj2nd4 1297 20 autoimmune autoimmune NN cord-009571-mygj2nd4 1297 21 and and CC cord-009571-mygj2nd4 1297 22 lymphoproliferative lymphoproliferative JJ cord-009571-mygj2nd4 1297 23 disease disease NN cord-009571-mygj2nd4 1297 24 . . . cord-009571-mygj2nd4 1298 1 We -PRON- PRP cord-009571-mygj2nd4 1298 2 studied study VBD cord-009571-mygj2nd4 1298 3 T t NN cord-009571-mygj2nd4 1298 4 lymphocyte lymphocyte NN cord-009571-mygj2nd4 1298 5 function function NN cord-009571-mygj2nd4 1298 6 in in IN cord-009571-mygj2nd4 1298 7 8 8 CD cord-009571-mygj2nd4 1298 8 young young JJ cord-009571-mygj2nd4 1298 9 ( ( -LRB- cord-009571-mygj2nd4 1298 10 3 3 CD cord-009571-mygj2nd4 1298 11 - - SYM cord-009571-mygj2nd4 1298 12 4 4 CD cord-009571-mygj2nd4 1298 13 month month NN cord-009571-mygj2nd4 1298 14 ) ) -RRB- cord-009571-mygj2nd4 1298 15 and and CC cord-009571-mygj2nd4 1298 16 9 9 CD cord-009571-mygj2nd4 1298 17 old old JJ cord-009571-mygj2nd4 1298 18 ( ( -LRB- cord-009571-mygj2nd4 1298 19 15 15 CD cord-009571-mygj2nd4 1298 20 - - SYM cord-009571-mygj2nd4 1298 21 20 20 CD cord-009571-mygj2nd4 1298 22 month month NN cord-009571-mygj2nd4 1298 23 ) ) -RRB- cord-009571-mygj2nd4 1299 1 male male NNP cord-009571-mygj2nd4 1299 2 B B NNP cord-009571-mygj2nd4 1299 3 / / SYM cord-009571-mygj2nd4 1299 4 W W NNP cord-009571-mygj2nd4 1299 5 mice mouse NNS cord-009571-mygj2nd4 1299 6 in in IN cord-009571-mygj2nd4 1299 7 separate separate JJ cord-009571-mygj2nd4 1299 8 paired pair VBN cord-009571-mygj2nd4 1299 9 experiments experiment NNS cord-009571-mygj2nd4 1299 10 . . . cord-009571-mygj2nd4 1300 1 The the DT cord-009571-mygj2nd4 1300 2 spleen spleen NN cord-009571-mygj2nd4 1300 3 cell cell NN cord-009571-mygj2nd4 1300 4 response response NN cord-009571-mygj2nd4 1300 5 to to IN cord-009571-mygj2nd4 1300 6 phytohemagglutinin phytohemagglutinin NNP cord-009571-mygj2nd4 1300 7 was be VBD cord-009571-mygj2nd4 1300 8 62,087 62,087 CD cord-009571-mygj2nd4 1300 9 cpm cpm NNS cord-009571-mygj2nd4 1300 10 ( ( -LRB- cord-009571-mygj2nd4 1300 11 geometric geometric JJ cord-009571-mygj2nd4 1300 12 mean mean NN cord-009571-mygj2nd4 1300 13 ) ) -RRB- cord-009571-mygj2nd4 1300 14 for for IN cord-009571-mygj2nd4 1300 15 young young JJ cord-009571-mygj2nd4 1300 16 mice mouse NNS cord-009571-mygj2nd4 1300 17 compared compare VBN cord-009571-mygj2nd4 1300 18 with with IN cord-009571-mygj2nd4 1300 19 490 490 CD cord-009571-mygj2nd4 1300 20 cpm cpm NN cord-009571-mygj2nd4 1300 21 for for IN cord-009571-mygj2nd4 1300 22 old old JJ cord-009571-mygj2nd4 1300 23 mice mouse NNS cord-009571-mygj2nd4 1300 24 ( ( -LRB- cord-009571-mygj2nd4 1300 25 P p NN cord-009571-mygj2nd4 1300 26 < < XX cord-009571-mygj2nd4 1300 27 0.OOOl 0.oool CD cord-009571-mygj2nd4 1300 28 ) ) -RRB- cord-009571-mygj2nd4 1300 29 . . . cord-009571-mygj2nd4 1301 1 When when WRB cord-009571-mygj2nd4 1301 2 spleen spleen NN cord-009571-mygj2nd4 1301 3 cells cell NNS cord-009571-mygj2nd4 1301 4 from from IN cord-009571-mygj2nd4 1301 5 young young JJ cord-009571-mygj2nd4 1301 6 and and CC cord-009571-mygj2nd4 1301 7 old old JJ cord-009571-mygj2nd4 1301 8 mice mouse NNS cord-009571-mygj2nd4 1301 9 were be VBD cord-009571-mygj2nd4 1301 10 mixed mix VBN cord-009571-mygj2nd4 1301 11 together together RB cord-009571-mygj2nd4 1301 12 , , , cord-009571-mygj2nd4 1301 13 there there EX cord-009571-mygj2nd4 1301 14 was be VBD cord-009571-mygj2nd4 1301 15 significant significant JJ cord-009571-mygj2nd4 1301 16 suppression suppression NN cord-009571-mygj2nd4 1301 17 of of IN cord-009571-mygj2nd4 1301 18 young young JJ cord-009571-mygj2nd4 1301 19 cells cell NNS cord-009571-mygj2nd4 1301 20 by by IN cord-009571-mygj2nd4 1301 21 old old JJ cord-009571-mygj2nd4 1301 22 splenocytes splenocyte NNS cord-009571-mygj2nd4 1301 23 in in IN cord-009571-mygj2nd4 1301 24 all all DT cord-009571-mygj2nd4 1301 25 experiments experiment NNS cord-009571-mygj2nd4 1301 26 ( ( -LRB- cord-009571-mygj2nd4 1301 27 57 57 CD cord-009571-mygj2nd4 1301 28 - - SYM cord-009571-mygj2nd4 1301 29 98 98 CD cord-009571-mygj2nd4 1301 30 % % NN cord-009571-mygj2nd4 1301 31 suppression suppression NN cord-009571-mygj2nd4 1301 32 ) ) -RRB- cord-009571-mygj2nd4 1301 33 . . . cord-009571-mygj2nd4 1302 1 This this DT cord-009571-mygj2nd4 1302 2 suppression suppression NN cord-009571-mygj2nd4 1302 3 is be VBZ cord-009571-mygj2nd4 1302 4 mediated mediate VBN cord-009571-mygj2nd4 1302 5 by by IN cord-009571-mygj2nd4 1302 6 a a DT cord-009571-mygj2nd4 1302 7 radio radio NN cord-009571-mygj2nd4 1302 8 - - HYPH cord-009571-mygj2nd4 1302 9 resistant resistant JJ cord-009571-mygj2nd4 1302 10 , , , cord-009571-mygj2nd4 1302 11 nonadherent nonadherent NN cord-009571-mygj2nd4 1302 12 , , , cord-009571-mygj2nd4 1302 13 mononuclear mononuclear JJ cord-009571-mygj2nd4 1302 14 leukocyte leukocyte NN cord-009571-mygj2nd4 1302 15 , , , cord-009571-mygj2nd4 1302 16 probably probably RB cord-009571-mygj2nd4 1302 17 a a DT cord-009571-mygj2nd4 1302 18 small small JJ cord-009571-mygj2nd4 1302 19 lymphocyte lymphocyte NN cord-009571-mygj2nd4 1302 20 . . . cord-009571-mygj2nd4 1303 1 Although although IN cord-009571-mygj2nd4 1303 2 this this DT cord-009571-mygj2nd4 1303 3 suppressor suppressor NN cord-009571-mygj2nd4 1303 4 cell cell NN cord-009571-mygj2nd4 1303 5 is be VBZ cord-009571-mygj2nd4 1303 6 eluted elute VBN cord-009571-mygj2nd4 1303 7 in in IN cord-009571-mygj2nd4 1303 8 the the DT cord-009571-mygj2nd4 1303 9 " " `` cord-009571-mygj2nd4 1303 10 T T NNP cord-009571-mygj2nd4 1303 11 cell cell NN cord-009571-mygj2nd4 1303 12 fraction fraction NN cord-009571-mygj2nd4 1303 13 " " '' cord-009571-mygj2nd4 1303 14 of of IN cord-009571-mygj2nd4 1303 15 a a DT cord-009571-mygj2nd4 1303 16 nylon nylon NN cord-009571-mygj2nd4 1303 17 wool wool NN cord-009571-mygj2nd4 1303 18 column column NN cord-009571-mygj2nd4 1303 19 , , , cord-009571-mygj2nd4 1303 20 it -PRON- PRP cord-009571-mygj2nd4 1303 21 can can MD cord-009571-mygj2nd4 1303 22 not not RB cord-009571-mygj2nd4 1303 23 be be VB cord-009571-mygj2nd4 1303 24 identified identify VBN cord-009571-mygj2nd4 1303 25 as as IN cord-009571-mygj2nd4 1303 26 a a DT cord-009571-mygj2nd4 1303 27 T t NN cord-009571-mygj2nd4 1303 28 cell cell NN cord-009571-mygj2nd4 1303 29 because because IN cord-009571-mygj2nd4 1303 30 it -PRON- PRP cord-009571-mygj2nd4 1303 31 is be VBZ cord-009571-mygj2nd4 1303 32 resistant resistant JJ cord-009571-mygj2nd4 1303 33 to to IN cord-009571-mygj2nd4 1303 34 anti4 anti4 NN cord-009571-mygj2nd4 1303 35 and and CC cord-009571-mygj2nd4 1303 36 complement complement VB cord-009571-mygj2nd4 1303 37 treatment treatment NN cord-009571-mygj2nd4 1303 38 . . . cord-009571-mygj2nd4 1304 1 In in IN cord-009571-mygj2nd4 1304 2 a a DT cord-009571-mygj2nd4 1304 3 typical typical JJ cord-009571-mygj2nd4 1304 4 experiment experiment NN cord-009571-mygj2nd4 1304 5 , , , cord-009571-mygj2nd4 1304 6 unfractionated unfractionated JJ cord-009571-mygj2nd4 1304 7 old old JJ cord-009571-mygj2nd4 1304 8 spleen spleen NN cord-009571-mygj2nd4 1304 9 cells cell NNS cord-009571-mygj2nd4 1304 10 incorporated incorporate VBD cord-009571-mygj2nd4 1304 11 291 291 CD cord-009571-mygj2nd4 1304 12 cpm cpm NNS cord-009571-mygj2nd4 1304 13 compared compare VBN cord-009571-mygj2nd4 1305 1 t t NNP cord-009571-mygj2nd4 1305 2 o o NNP cord-009571-mygj2nd4 1305 3 42,825 42,825 CD cord-009571-mygj2nd4 1305 4 cpm cpm NN cord-009571-mygj2nd4 1305 5 for for IN cord-009571-mygj2nd4 1305 6 young young JJ cord-009571-mygj2nd4 1305 7 spleen spleen NN cord-009571-mygj2nd4 1305 8 cells cell NNS cord-009571-mygj2nd4 1305 9 . . . cord-009571-mygj2nd4 1306 1 A a DT cord-009571-mygj2nd4 1306 2 mixture mixture NN cord-009571-mygj2nd4 1306 3 of of IN cord-009571-mygj2nd4 1306 4 old old JJ cord-009571-mygj2nd4 1306 5 and and CC cord-009571-mygj2nd4 1306 6 young young JJ cord-009571-mygj2nd4 1306 7 cells cell NNS cord-009571-mygj2nd4 1306 8 incorporated incorporate VBD cord-009571-mygj2nd4 1306 9 6,683 6,683 CD cord-009571-mygj2nd4 1306 10 cpm cpm NN cord-009571-mygj2nd4 1306 11 , , , cord-009571-mygj2nd4 1306 12 whereas whereas IN cord-009571-mygj2nd4 1306 13 the the DT cord-009571-mygj2nd4 1306 14 predicted predict VBN cord-009571-mygj2nd4 1306 15 incorporation incorporation NN cord-009571-mygj2nd4 1306 16 for for IN cord-009571-mygj2nd4 1306 17 this this DT cord-009571-mygj2nd4 1306 18 50/50 50/50 CD cord-009571-mygj2nd4 1306 19 mixture mixture NN cord-009571-mygj2nd4 1306 20 was be VBD cord-009571-mygj2nd4 1306 21 21,558 21,558 CD cord-009571-mygj2nd4 1306 22 cpm cpm NN cord-009571-mygj2nd4 1306 23 ( ( -LRB- cord-009571-mygj2nd4 1306 24 69 69 CD cord-009571-mygj2nd4 1306 25 % % NN cord-009571-mygj2nd4 1306 26 suppression suppression NN cord-009571-mygj2nd4 1306 27 ) ) -RRB- cord-009571-mygj2nd4 1306 28 . . . cord-009571-mygj2nd4 1307 1 Old old JJ cord-009571-mygj2nd4 1307 2 spleen spleen NN cord-009571-mygj2nd4 1307 3 cells cell NNS cord-009571-mygj2nd4 1307 4 from from IN cord-009571-mygj2nd4 1307 5 the the DT cord-009571-mygj2nd4 1307 6 T T NNP cord-009571-mygj2nd4 1307 7 cell cell NN cord-009571-mygj2nd4 1307 8 fraction fraction NN cord-009571-mygj2nd4 1307 9 of of IN cord-009571-mygj2nd4 1307 10 the the DT cord-009571-mygj2nd4 1307 11 nylon nylon NN cord-009571-mygj2nd4 1307 12 wool wool NN cord-009571-mygj2nd4 1307 13 column column NN cord-009571-mygj2nd4 1307 14 were be VBD cord-009571-mygj2nd4 1307 15 enriched enrich VBN cord-009571-mygj2nd4 1307 16 for for IN cord-009571-mygj2nd4 1307 17 suppressor suppressor NN cord-009571-mygj2nd4 1307 18 cells cell NNS cord-009571-mygj2nd4 1307 19 ( ( -LRB- cord-009571-mygj2nd4 1307 20 95 95 CD cord-009571-mygj2nd4 1307 21 % % NN cord-009571-mygj2nd4 1307 22 suppression suppression NN cord-009571-mygj2nd4 1307 23 in in IN cord-009571-mygj2nd4 1307 24 the the DT cord-009571-mygj2nd4 1307 25 mixing mix VBG cord-009571-mygj2nd4 1307 26 experiment experiment NN cord-009571-mygj2nd4 1307 27 ) ) -RRB- cord-009571-mygj2nd4 1307 28 . . . cord-009571-mygj2nd4 1308 1 In in IN cord-009571-mygj2nd4 1308 2 contrast contrast NN cord-009571-mygj2nd4 1308 3 , , , cord-009571-mygj2nd4 1308 4 the the DT cord-009571-mygj2nd4 1308 5 B b NN cord-009571-mygj2nd4 1308 6 cell cell NN cord-009571-mygj2nd4 1308 7 fraction fraction NN cord-009571-mygj2nd4 1308 8 was be VBD cord-009571-mygj2nd4 1308 9 completely completely RB cord-009571-mygj2nd4 1308 10 depleted deplete VBN cord-009571-mygj2nd4 1308 11 of of IN cord-009571-mygj2nd4 1308 12 suppressor suppressor NN cord-009571-mygj2nd4 1308 13 activity activity NN cord-009571-mygj2nd4 1308 14 ( ( -LRB- cord-009571-mygj2nd4 1308 15 actually actually RB cord-009571-mygj2nd4 1308 16 23 23 CD cord-009571-mygj2nd4 1308 17 % % NN cord-009571-mygj2nd4 1308 18 greater great JJR cord-009571-mygj2nd4 1308 19 than than IN cord-009571-mygj2nd4 1308 20 predicted predict VBN cord-009571-mygj2nd4 1308 21 incorporation incorporation NN cord-009571-mygj2nd4 1308 22 ) ) -RRB- cord-009571-mygj2nd4 1308 23 . . . cord-009571-mygj2nd4 1309 1 Anti4 Anti4 NNP cord-009571-mygj2nd4 1309 2 and and CC cord-009571-mygj2nd4 1309 3 complement complement VB cord-009571-mygj2nd4 1309 4 treatment treatment NN cord-009571-mygj2nd4 1309 5 of of IN cord-009571-mygj2nd4 1309 6 spleen spleen NN cord-009571-mygj2nd4 1309 7 cells cell NNS cord-009571-mygj2nd4 1309 8 from from IN cord-009571-mygj2nd4 1309 9 a a DT cord-009571-mygj2nd4 1309 10 n n NN cord-009571-mygj2nd4 1309 11 18 18 CD cord-009571-mygj2nd4 1309 12 month month NN cord-009571-mygj2nd4 1309 13 old old JJ cord-009571-mygj2nd4 1309 14 B B NNP cord-009571-mygj2nd4 1309 15 / / SYM cord-009571-mygj2nd4 1309 16 W W NNP cord-009571-mygj2nd4 1309 17 mouse mouse NN cord-009571-mygj2nd4 1309 18 demonstrated demonstrate VBD cord-009571-mygj2nd4 1309 19 80 80 CD cord-009571-mygj2nd4 1309 20 % % NN cord-009571-mygj2nd4 1309 21 suppression suppression NN cord-009571-mygj2nd4 1309 22 by by IN cord-009571-mygj2nd4 1309 23 the the DT cord-009571-mygj2nd4 1309 24 untreated untreated JJ cord-009571-mygj2nd4 1309 25 cells cell NNS cord-009571-mygj2nd4 1309 26 and and CC cord-009571-mygj2nd4 1309 27 98 98 CD cord-009571-mygj2nd4 1309 28 % % NN cord-009571-mygj2nd4 1309 29 suppression suppression NN cord-009571-mygj2nd4 1309 30 by by IN cord-009571-mygj2nd4 1309 31 the the DT cord-009571-mygj2nd4 1309 32 preparation preparation NN cord-009571-mygj2nd4 1309 33 depleted deplete VBN cord-009571-mygj2nd4 1309 34 of of IN cord-009571-mygj2nd4 1309 35 & & CC cord-009571-mygj2nd4 1309 36 bearing bearing NN cord-009571-mygj2nd4 1309 37 cells cell NNS cord-009571-mygj2nd4 1309 38 . . . cord-009571-mygj2nd4 1310 1 These these DT cord-009571-mygj2nd4 1310 2 results result NNS cord-009571-mygj2nd4 1310 3 have have VBP cord-009571-mygj2nd4 1310 4 been be VBN cord-009571-mygj2nd4 1310 5 consistently consistently RB cord-009571-mygj2nd4 1310 6 reproduced reproduce VBN cord-009571-mygj2nd4 1310 7 . . . cord-009571-mygj2nd4 1311 1 There there EX cord-009571-mygj2nd4 1311 2 is be VBZ cord-009571-mygj2nd4 1311 3 no no DT cord-009571-mygj2nd4 1311 4 evidence evidence NN cord-009571-mygj2nd4 1311 5 of of IN cord-009571-mygj2nd4 1311 6 a a DT cord-009571-mygj2nd4 1311 7 suppressor suppressor NN cord-009571-mygj2nd4 1311 8 cell cell NN cord-009571-mygj2nd4 1311 9 in in IN cord-009571-mygj2nd4 1311 10 old old JJ cord-009571-mygj2nd4 1311 11 mice mouse NNS cord-009571-mygj2nd4 1311 12 of of IN cord-009571-mygj2nd4 1311 13 four four CD cord-009571-mygj2nd4 1311 14 normal normal JJ cord-009571-mygj2nd4 1311 15 strains strain NNS cord-009571-mygj2nd4 1311 16 ( ( -LRB- cord-009571-mygj2nd4 1311 17 DBA/2 DBA/2 NNP cord-009571-mygj2nd4 1311 18 , , , cord-009571-mygj2nd4 1311 19 C57B1/6 C57B1/6 NNP cord-009571-mygj2nd4 1311 20 , , , cord-009571-mygj2nd4 1311 21 Balb Balb NNP cord-009571-mygj2nd4 1311 22 / / SYM cord-009571-mygj2nd4 1311 23 c c NNP cord-009571-mygj2nd4 1311 24 , , , cord-009571-mygj2nd4 1311 25 and and CC cord-009571-mygj2nd4 1311 26 NZW NZW NNP cord-009571-mygj2nd4 1311 27 ) ) -RRB- cord-009571-mygj2nd4 1311 28 . . . cord-009571-mygj2nd4 1312 1 We -PRON- PRP cord-009571-mygj2nd4 1312 2 conclude conclude VBP cord-009571-mygj2nd4 1312 3 that that IN cord-009571-mygj2nd4 1312 4 a a DT cord-009571-mygj2nd4 1312 5 mononuclear mononuclear JJ cord-009571-mygj2nd4 1312 6 suppressor suppressor NN cord-009571-mygj2nd4 1312 7 cell cell NN cord-009571-mygj2nd4 1312 8 , , , cord-009571-mygj2nd4 1312 9 probably probably RB cord-009571-mygj2nd4 1312 10 a a DT cord-009571-mygj2nd4 1312 11 lymphocyte lymphocyte NN cord-009571-mygj2nd4 1312 12 , , , cord-009571-mygj2nd4 1312 13 contributes contribute VBZ cord-009571-mygj2nd4 1312 14 significantly significantly RB cord-009571-mygj2nd4 1312 15 to to IN cord-009571-mygj2nd4 1312 16 the the DT cord-009571-mygj2nd4 1312 17 severely severely RB cord-009571-mygj2nd4 1312 18 depressed depressed JJ cord-009571-mygj2nd4 1312 19 T t NN cord-009571-mygj2nd4 1312 20 lymphocyte lymphocyte NN cord-009571-mygj2nd4 1312 21 function function NN cord-009571-mygj2nd4 1312 22 of of IN cord-009571-mygj2nd4 1312 23 aging age VBG cord-009571-mygj2nd4 1312 24 B B NNP cord-009571-mygj2nd4 1312 25 / / SYM cord-009571-mygj2nd4 1312 26 W w NN cord-009571-mygj2nd4 1312 27 mice mouse NNS cord-009571-mygj2nd4 1312 28 . . . cord-009571-mygj2nd4 1313 1 This this DT cord-009571-mygj2nd4 1313 2 suppressor suppressor NN cord-009571-mygj2nd4 1313 3 mechanism mechanism NN cord-009571-mygj2nd4 1313 4 may may MD cord-009571-mygj2nd4 1313 5 participate participate VB cord-009571-mygj2nd4 1313 6 in in IN cord-009571-mygj2nd4 1313 7 the the DT cord-009571-mygj2nd4 1313 8 pathogenesis pathogenesis NN cord-009571-mygj2nd4 1313 9 of of IN cord-009571-mygj2nd4 1313 10 the the DT cord-009571-mygj2nd4 1313 11 lymphoproliferative lymphoproliferative JJ cord-009571-mygj2nd4 1313 12 and and CC cord-009571-mygj2nd4 1313 13 autoimmune autoimmune JJ cord-009571-mygj2nd4 1313 14 disorder disorder NN cord-009571-mygj2nd4 1313 15 characteristic characteristic NN cord-009571-mygj2nd4 1313 16 of of IN cord-009571-mygj2nd4 1313 17 the the DT cord-009571-mygj2nd4 1313 18 strain strain NN cord-009571-mygj2nd4 1313 19 . . . cord-009571-mygj2nd4 1314 1 None none NN cord-009571-mygj2nd4 1314 2 of of IN cord-009571-mygj2nd4 1314 3 the the DT cord-009571-mygj2nd4 1314 4 clinical clinical JJ cord-009571-mygj2nd4 1314 5 and and CC cord-009571-mygj2nd4 1314 6 laboratory laboratory NN cord-009571-mygj2nd4 1314 7 parameters parameter NNS cord-009571-mygj2nd4 1314 8 presently presently RB cord-009571-mygj2nd4 1314 9 used use VBN cord-009571-mygj2nd4 1314 10 for for IN cord-009571-mygj2nd4 1314 11 the the DT cord-009571-mygj2nd4 1314 12 assessment assessment NN cord-009571-mygj2nd4 1314 13 of of IN cord-009571-mygj2nd4 1314 14 SLE SLE NNP cord-009571-mygj2nd4 1314 15 kidney kidney NN cord-009571-mygj2nd4 1314 16 disease disease NN cord-009571-mygj2nd4 1314 17 is be VBZ cord-009571-mygj2nd4 1314 18 completely completely RB cord-009571-mygj2nd4 1314 19 reliable reliable JJ cord-009571-mygj2nd4 1314 20 . . . cord-009571-mygj2nd4 1315 1 Immunofluorescence immunofluorescence NN cord-009571-mygj2nd4 1315 2 of of IN cord-009571-mygj2nd4 1315 3 the the DT cord-009571-mygj2nd4 1315 4 urinary urinary JJ cord-009571-mygj2nd4 1315 5 sediment sediment NN cord-009571-mygj2nd4 1315 6 ( ( -LRB- cord-009571-mygj2nd4 1315 7 IFUS IFUS NNP cord-009571-mygj2nd4 1315 8 ) ) -RRB- cord-009571-mygj2nd4 1315 9 has have VBZ cord-009571-mygj2nd4 1315 10 been be VBN cord-009571-mygj2nd4 1315 11 recently recently RB cord-009571-mygj2nd4 1315 12 reported report VBN cord-009571-mygj2nd4 1315 13 to to TO cord-009571-mygj2nd4 1315 14 accurately accurately RB cord-009571-mygj2nd4 1315 15 predict predict VB cord-009571-mygj2nd4 1315 16 the the DT cord-009571-mygj2nd4 1315 17 rejection rejection NN cord-009571-mygj2nd4 1315 18 of of IN cord-009571-mygj2nd4 1315 19 renal renal JJ cord-009571-mygj2nd4 1315 20 transplants transplant NNS cord-009571-mygj2nd4 1315 21 , , , cord-009571-mygj2nd4 1315 22 and and CC cord-009571-mygj2nd4 1315 23 the the DT cord-009571-mygj2nd4 1315 24 purpose purpose NN cord-009571-mygj2nd4 1315 25 of of IN cord-009571-mygj2nd4 1315 26 this this DT cord-009571-mygj2nd4 1315 27 study study NN cord-009571-mygj2nd4 1315 28 was be VBD cord-009571-mygj2nd4 1315 29 to to TO cord-009571-mygj2nd4 1315 30 evaluate evaluate VB cord-009571-mygj2nd4 1315 31 its -PRON- PRP$ cord-009571-mygj2nd4 1315 32 usefulness usefulness NN cord-009571-mygj2nd4 1315 33 in in IN cord-009571-mygj2nd4 1315 34 renal renal JJ cord-009571-mygj2nd4 1315 35 SLE sle NN cord-009571-mygj2nd4 1315 36 . . . cord-009571-mygj2nd4 1316 1 Thirty thirty CD cord-009571-mygj2nd4 1316 2 consecutive consecutive JJ cord-009571-mygj2nd4 1316 3 patients patient NNS cord-009571-mygj2nd4 1316 4 who who WP cord-009571-mygj2nd4 1316 5 met meet VBD cord-009571-mygj2nd4 1316 6 the the DT cord-009571-mygj2nd4 1316 7 ARA ARA NNP cord-009571-mygj2nd4 1316 8 Preliminary Preliminary NNP cord-009571-mygj2nd4 1316 9 Criteria Criteria NNP cord-009571-mygj2nd4 1316 10 for for IN cord-009571-mygj2nd4 1316 11 SLE SLE NNP cord-009571-mygj2nd4 1316 12 were be VBD cord-009571-mygj2nd4 1316 13 included include VBN cord-009571-mygj2nd4 1316 14 in in IN cord-009571-mygj2nd4 1316 15 the the DT cord-009571-mygj2nd4 1316 16 study study NN cord-009571-mygj2nd4 1316 17 . . . cord-009571-mygj2nd4 1317 1 All all DT cord-009571-mygj2nd4 1317 2 had have VBD cord-009571-mygj2nd4 1317 3 recent recent JJ cord-009571-mygj2nd4 1317 4 kidney kidney NN cord-009571-mygj2nd4 1317 5 biopsies biopsy NNS cord-009571-mygj2nd4 1317 6 and and CC cord-009571-mygj2nd4 1317 7 were be VBD cord-009571-mygj2nd4 1317 8 treated treat VBN cord-009571-mygj2nd4 1317 9 with with IN cord-009571-mygj2nd4 1317 10 prednisone prednisone NNP cord-009571-mygj2nd4 1317 11 and and CC cord-009571-mygj2nd4 1317 12 immunosuppressors immunosuppressor NNS cord-009571-mygj2nd4 1317 13 at at IN cord-009571-mygj2nd4 1317 14 usual usual JJ cord-009571-mygj2nd4 1317 15 doses dose NNS cord-009571-mygj2nd4 1317 16 with with IN cord-009571-mygj2nd4 1317 17 urinalysis urinalysis NN cord-009571-mygj2nd4 1317 18 , , , cord-009571-mygj2nd4 1317 19 urinary urinary JJ cord-009571-mygj2nd4 1317 20 light light JJ cord-009571-mygj2nd4 1317 21 chains chain NNS cord-009571-mygj2nd4 1317 22 , , , cord-009571-mygj2nd4 1317 23 C3 C3 NNP cord-009571-mygj2nd4 1317 24 , , , cord-009571-mygj2nd4 1317 25 anti anti JJ cord-009571-mygj2nd4 1317 26 - - JJ cord-009571-mygj2nd4 1317 27 DNA dna JJ cord-009571-mygj2nd4 1317 28 binding binding NN cord-009571-mygj2nd4 1317 29 , , , cord-009571-mygj2nd4 1317 30 NPN NPN NNP cord-009571-mygj2nd4 1317 31 , , , cord-009571-mygj2nd4 1317 32 and and CC cord-009571-mygj2nd4 1317 33 creatinine creatinine NN cord-009571-mygj2nd4 1317 34 as as IN cord-009571-mygj2nd4 1317 35 parameters parameter NNS cord-009571-mygj2nd4 1317 36 of of IN cord-009571-mygj2nd4 1317 37 activity activity NN cord-009571-mygj2nd4 1317 38 . . . cord-009571-mygj2nd4 1318 1 Random random JJ cord-009571-mygj2nd4 1318 2 urine urine NN cord-009571-mygj2nd4 1318 3 specimens specimen NNS cord-009571-mygj2nd4 1318 4 were be VBD cord-009571-mygj2nd4 1318 5 collected collect VBN cord-009571-mygj2nd4 1318 6 weekly weekly RB cord-009571-mygj2nd4 1318 7 for for IN cord-009571-mygj2nd4 1318 8 6 6 CD cord-009571-mygj2nd4 1318 9 months month NNS cord-009571-mygj2nd4 1318 10 and and CC cord-009571-mygj2nd4 1318 11 the the DT cord-009571-mygj2nd4 1318 12 urinary urinary JJ cord-009571-mygj2nd4 1318 13 sediment sediment NN cord-009571-mygj2nd4 1318 14 was be VBD cord-009571-mygj2nd4 1318 15 studied study VBN cord-009571-mygj2nd4 1318 16 by by IN cord-009571-mygj2nd4 1318 17 direct direct JJ cord-009571-mygj2nd4 1318 18 immunofluorescence immunofluorescence NN cord-009571-mygj2nd4 1318 19 with with IN cord-009571-mygj2nd4 1318 20 antisera antisera NNP cord-009571-mygj2nd4 1318 21 anti anti NNP cord-009571-mygj2nd4 1318 22 IgA IgA NNP cord-009571-mygj2nd4 1318 23 , , , cord-009571-mygj2nd4 1318 24 IgG IgG NNP cord-009571-mygj2nd4 1318 25 , , , cord-009571-mygj2nd4 1318 26 Ig Ig NNP cord-009571-mygj2nd4 1318 27 M M NNP cord-009571-mygj2nd4 1318 28 , , , cord-009571-mygj2nd4 1318 29 and and CC cord-009571-mygj2nd4 1318 30 fibrinogen fibrinogen NN cord-009571-mygj2nd4 1318 31 degradation degradation NN cord-009571-mygj2nd4 1318 32 products product NNS cord-009571-mygj2nd4 1318 33 . . . cord-009571-mygj2nd4 1319 1 Clinicai Clinicai NNP cord-009571-mygj2nd4 1319 2 grading grading NN cord-009571-mygj2nd4 1319 3 and and CC cord-009571-mygj2nd4 1319 4 fluorescence fluorescence NN cord-009571-mygj2nd4 1319 5 readings reading NNS cord-009571-mygj2nd4 1319 6 were be VBD cord-009571-mygj2nd4 1319 7 done do VBN cord-009571-mygj2nd4 1319 8 by by IN cord-009571-mygj2nd4 1319 9 independent independent JJ cord-009571-mygj2nd4 1319 10 observers observer NNS cord-009571-mygj2nd4 1319 11 . . . cord-009571-mygj2nd4 1320 1 Nine nine CD cord-009571-mygj2nd4 1320 2 patients patient NNS cord-009571-mygj2nd4 1320 3 had have VBD cord-009571-mygj2nd4 1320 4 normal normal JJ cord-009571-mygj2nd4 1320 5 kidney kidney NN cord-009571-mygj2nd4 1320 6 biopsies biopsy NNS cord-009571-mygj2nd4 1320 7 and and CC cord-009571-mygj2nd4 1320 8 IFUS IFUS NNP cord-009571-mygj2nd4 1320 9 was be VBD cord-009571-mygj2nd4 1320 10 always always RB cord-009571-mygj2nd4 1320 11 negative negative JJ cord-009571-mygj2nd4 1320 12 . . . cord-009571-mygj2nd4 1321 1 Nine nine CD cord-009571-mygj2nd4 1321 2 patients patient NNS cord-009571-mygj2nd4 1321 3 had have VBD cord-009571-mygj2nd4 1321 4 abnormal abnormal JJ cord-009571-mygj2nd4 1321 5 biopsies biopsy NNS cord-009571-mygj2nd4 1321 6 , , , cord-009571-mygj2nd4 1321 7 were be VBD cord-009571-mygj2nd4 1321 8 classified classify VBN cord-009571-mygj2nd4 1321 9 as as IN cord-009571-mygj2nd4 1321 10 inactive inactive JJ cord-009571-mygj2nd4 1321 11 , , , cord-009571-mygj2nd4 1321 12 and and CC cord-009571-mygj2nd4 1321 13 IFUS IFUS NNP cord-009571-mygj2nd4 1321 14 was be VBD cord-009571-mygj2nd4 1321 15 always always RB cord-009571-mygj2nd4 1321 16 negative negative JJ cord-009571-mygj2nd4 1321 17 . . . cord-009571-mygj2nd4 1322 1 In in IN cord-009571-mygj2nd4 1322 2 12 12 CD cord-009571-mygj2nd4 1322 3 patients patient NNS cord-009571-mygj2nd4 1322 4 with with IN cord-009571-mygj2nd4 1322 5 abnormal abnormal JJ cord-009571-mygj2nd4 1322 6 biopsies biopsy NNS cord-009571-mygj2nd4 1322 7 and and CC cord-009571-mygj2nd4 1322 8 active active JJ cord-009571-mygj2nd4 1322 9 renal renal JJ cord-009571-mygj2nd4 1322 10 disease disease NN cord-009571-mygj2nd4 1322 11 , , , cord-009571-mygj2nd4 1322 12 IFUS IFUS NNP cord-009571-mygj2nd4 1322 13 was be VBD cord-009571-mygj2nd4 1322 14 always always RB cord-009571-mygj2nd4 1322 15 positive positive JJ cord-009571-mygj2nd4 1322 16 , , , cord-009571-mygj2nd4 1322 17 even even RB cord-009571-mygj2nd4 1322 18 before before IN cord-009571-mygj2nd4 1322 19 the the DT cord-009571-mygj2nd4 1322 20 appearence appearence NN cord-009571-mygj2nd4 1322 21 of of IN cord-009571-mygj2nd4 1322 22 proteinuria proteinuria NNP cord-009571-mygj2nd4 1322 23 , , , cord-009571-mygj2nd4 1322 24 hemoglobinuria hemoglobinuria NNP cord-009571-mygj2nd4 1322 25 , , , cord-009571-mygj2nd4 1322 26 casts cast VBZ cord-009571-mygj2nd4 1322 27 , , , cord-009571-mygj2nd4 1322 28 and and CC cord-009571-mygj2nd4 1322 29 light light JJ cord-009571-mygj2nd4 1322 30 chains chain NNS cord-009571-mygj2nd4 1322 31 . . . cord-009571-mygj2nd4 1323 1 IFUS IFUS NNP cord-009571-mygj2nd4 1323 2 was be VBD cord-009571-mygj2nd4 1323 3 positive positive JJ cord-009571-mygj2nd4 1323 4 1 1 CD cord-009571-mygj2nd4 1323 5 to to TO cord-009571-mygj2nd4 1323 6 3 3 CD cord-009571-mygj2nd4 1323 7 months month NNS cord-009571-mygj2nd4 1323 8 before before IN cord-009571-mygj2nd4 1323 9 C3 C3 NNP cord-009571-mygj2nd4 1323 10 dropped drop VBD cord-009571-mygj2nd4 1323 11 in in IN cord-009571-mygj2nd4 1323 12 4 4 CD cord-009571-mygj2nd4 1323 13 patients patient NNS cord-009571-mygj2nd4 1323 14 and and CC cord-009571-mygj2nd4 1323 15 became become VBD cord-009571-mygj2nd4 1323 16 negative negative JJ cord-009571-mygj2nd4 1323 17 1 1 CD cord-009571-mygj2nd4 1323 18 to to IN cord-009571-mygj2nd4 1323 19 4 4 CD cord-009571-mygj2nd4 1323 20 months month NNS cord-009571-mygj2nd4 1323 21 before before IN cord-009571-mygj2nd4 1323 22 C3 C3 NNP cord-009571-mygj2nd4 1323 23 returned return VBD cord-009571-mygj2nd4 1323 24 to to IN cord-009571-mygj2nd4 1323 25 normal normal JJ cord-009571-mygj2nd4 1323 26 in in IN cord-009571-mygj2nd4 1323 27 7 7 CD cord-009571-mygj2nd4 1323 28 patients patient NNS cord-009571-mygj2nd4 1323 29 . . . cord-009571-mygj2nd4 1324 1 In in IN cord-009571-mygj2nd4 1324 2 the the DT cord-009571-mygj2nd4 1324 3 presence presence NN cord-009571-mygj2nd4 1324 4 of of IN cord-009571-mygj2nd4 1324 5 residual residual JJ cord-009571-mygj2nd4 1324 6 proteinuria proteinuria NN cord-009571-mygj2nd4 1324 7 , , , cord-009571-mygj2nd4 1324 8 IFUS IFUS NNP cord-009571-mygj2nd4 1324 9 became become VBD cord-009571-mygj2nd4 1324 10 negative negative JJ cord-009571-mygj2nd4 1324 11 in in IN cord-009571-mygj2nd4 1324 12 5 5 CD cord-009571-mygj2nd4 1324 13 patients patient NNS cord-009571-mygj2nd4 1324 14 . . . cord-009571-mygj2nd4 1325 1 There there EX cord-009571-mygj2nd4 1325 2 was be VBD cord-009571-mygj2nd4 1325 3 no no DT cord-009571-mygj2nd4 1325 4 correlation correlation NN cord-009571-mygj2nd4 1325 5 be be VB cord-009571-mygj2nd4 1325 6 - - : cord-009571-mygj2nd4 1325 7 tween tween NN cord-009571-mygj2nd4 1325 8 the the DT cord-009571-mygj2nd4 1325 9 histological histological JJ cord-009571-mygj2nd4 1325 10 type type NN cord-009571-mygj2nd4 1325 11 and and CC cord-009571-mygj2nd4 1325 12 the the DT cord-009571-mygj2nd4 1325 13 immunofluorescence immunofluorescence NN cord-009571-mygj2nd4 1325 14 findings finding NNS cord-009571-mygj2nd4 1325 15 in in IN cord-009571-mygj2nd4 1325 16 the the DT cord-009571-mygj2nd4 1325 17 kidney kidney NN cord-009571-mygj2nd4 1325 18 biopsy biopsy NN cord-009571-mygj2nd4 1325 19 with with IN cord-009571-mygj2nd4 1325 20 the the DT cord-009571-mygj2nd4 1325 21 type type NN cord-009571-mygj2nd4 1325 22 of of IN cord-009571-mygj2nd4 1325 23 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 1325 24 found find VBN cord-009571-mygj2nd4 1325 25 in in IN cord-009571-mygj2nd4 1325 26 the the DT cord-009571-mygj2nd4 1325 27 urine urine NN cord-009571-mygj2nd4 1325 28 . . . cord-009571-mygj2nd4 1326 1 This this DT cord-009571-mygj2nd4 1326 2 procedure procedure NN cord-009571-mygj2nd4 1326 3 is be VBZ cord-009571-mygj2nd4 1326 4 easy easy JJ cord-009571-mygj2nd4 1326 5 to to TO cord-009571-mygj2nd4 1326 6 perform perform VB cord-009571-mygj2nd4 1326 7 , , , cord-009571-mygj2nd4 1326 8 not not RB cord-009571-mygj2nd4 1326 9 costly costly JJ cord-009571-mygj2nd4 1326 10 , , , cord-009571-mygj2nd4 1326 11 and and CC cord-009571-mygj2nd4 1326 12 the the DT cord-009571-mygj2nd4 1326 13 results result NNS cord-009571-mygj2nd4 1326 14 are be VBP cord-009571-mygj2nd4 1326 15 available available JJ cord-009571-mygj2nd4 1326 16 within within IN cord-009571-mygj2nd4 1326 17 1 1 CD cord-009571-mygj2nd4 1326 18 hour hour NN cord-009571-mygj2nd4 1326 19 . . . cord-009571-mygj2nd4 1327 1 Our -PRON- PRP$ cord-009571-mygj2nd4 1327 2 data datum NNS cord-009571-mygj2nd4 1327 3 suggest suggest VBP cord-009571-mygj2nd4 1327 4 that that IN cord-009571-mygj2nd4 1327 5 it -PRON- PRP cord-009571-mygj2nd4 1327 6 reflects reflect VBZ cord-009571-mygj2nd4 1327 7 the the DT cord-009571-mygj2nd4 1327 8 changes change NNS cord-009571-mygj2nd4 1327 9 in in IN cord-009571-mygj2nd4 1327 10 renal renal JJ cord-009571-mygj2nd4 1327 11 status status NN cord-009571-mygj2nd4 1327 12 months month NNS cord-009571-mygj2nd4 1327 13 before before IN cord-009571-mygj2nd4 1327 14 the the DT cord-009571-mygj2nd4 1327 15 other other JJ cord-009571-mygj2nd4 1327 16 parameters parameter NNS cord-009571-mygj2nd4 1327 17 and and CC cord-009571-mygj2nd4 1327 18 therefore therefore RB cord-009571-mygj2nd4 1327 19 it -PRON- PRP cord-009571-mygj2nd4 1327 20 may may MD cord-009571-mygj2nd4 1327 21 be be VB cord-009571-mygj2nd4 1327 22 a a DT cord-009571-mygj2nd4 1327 23 valuable valuable JJ cord-009571-mygj2nd4 1327 24 method method NN cord-009571-mygj2nd4 1327 25 for for IN cord-009571-mygj2nd4 1327 26 guiding guide VBG cord-009571-mygj2nd4 1327 27 a a DT cord-009571-mygj2nd4 1327 28 more more RBR cord-009571-mygj2nd4 1327 29 flexible flexible JJ cord-009571-mygj2nd4 1327 30 treatment treatment NN cord-009571-mygj2nd4 1327 31 of of IN cord-009571-mygj2nd4 1327 32 patients patient NNS cord-009571-mygj2nd4 1327 33 with with IN cord-009571-mygj2nd4 1327 34 SLE SLE NNP cord-009571-mygj2nd4 1327 35 kidney kidney NN cord-009571-mygj2nd4 1327 36 disease disease NN cord-009571-mygj2nd4 1327 37 . . . cord-009571-mygj2nd4 1328 1 Fifteen fifteen CD cord-009571-mygj2nd4 1328 2 percent percent NN cord-009571-mygj2nd4 1328 3 or or CC cord-009571-mygj2nd4 1328 4 less less JJR cord-009571-mygj2nd4 1328 5 of of IN cord-009571-mygj2nd4 1328 6 patients patient NNS cord-009571-mygj2nd4 1328 7 with with IN cord-009571-mygj2nd4 1328 8 juvenile juvenile JJ cord-009571-mygj2nd4 1328 9 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1328 10 arthritis arthritis NN cord-009571-mygj2nd4 1328 11 ( ( -LRB- cord-009571-mygj2nd4 1328 12 JRA JRA NNP cord-009571-mygj2nd4 1328 13 ) ) -RRB- cord-009571-mygj2nd4 1328 14 have have VBP cord-009571-mygj2nd4 1328 15 positive positive JJ cord-009571-mygj2nd4 1328 16 latex latex NN cord-009571-mygj2nd4 1328 17 fixation fixation NN cord-009571-mygj2nd4 1328 18 tests test NNS cord-009571-mygj2nd4 1328 19 ( ( -LRB- cord-009571-mygj2nd4 1328 20 LFT LFT NNP cord-009571-mygj2nd4 1328 21 ) ) -RRB- cord-009571-mygj2nd4 1328 22 ; ; : cord-009571-mygj2nd4 1328 23 whereas whereas RB cord-009571-mygj2nd4 1328 24 , , , cord-009571-mygj2nd4 1328 25 approximately approximately RB cord-009571-mygj2nd4 1328 26 45 45 CD cord-009571-mygj2nd4 1328 27 % % NN cord-009571-mygj2nd4 1328 28 have have VBP cord-009571-mygj2nd4 1328 29 hidden hide VBN cord-009571-mygj2nd4 1328 30 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1328 31 factor factor NN cord-009571-mygj2nd4 1328 32 ( ( -LRB- cord-009571-mygj2nd4 1328 33 RF rf NN cord-009571-mygj2nd4 1328 34 ) ) -RRB- cord-009571-mygj2nd4 1329 1 ( ( -LRB- cord-009571-mygj2nd4 1329 2 19s 19s . cord-009571-mygj2nd4 1330 1 IgM IgM NNP cord-009571-mygj2nd4 1330 2 R R NNP cord-009571-mygj2nd4 1330 3 F F NNP cord-009571-mygj2nd4 1330 4 in in IN cord-009571-mygj2nd4 1330 5 the the DT cord-009571-mygj2nd4 1330 6 peripheral peripheral JJ cord-009571-mygj2nd4 1330 7 blood blood NN cord-009571-mygj2nd4 1330 8 probably probably RB cord-009571-mygj2nd4 1330 9 bound bind VBN cord-009571-mygj2nd4 1330 10 with with IN cord-009571-mygj2nd4 1330 11 7 7 CD cord-009571-mygj2nd4 1330 12 s s NNP cord-009571-mygj2nd4 1330 13 IgG igg NN cord-009571-mygj2nd4 1330 14 and and CC cord-009571-mygj2nd4 1330 15 , , , cord-009571-mygj2nd4 1330 16 therefore therefore RB cord-009571-mygj2nd4 1330 17 , , , cord-009571-mygj2nd4 1330 18 not not RB cord-009571-mygj2nd4 1330 19 detectable detectable JJ cord-009571-mygj2nd4 1330 20 by by IN cord-009571-mygj2nd4 1330 21 the the DT cord-009571-mygj2nd4 1330 22 standard standard JJ cord-009571-mygj2nd4 1330 23 LFT LFT NNP cord-009571-mygj2nd4 1330 24 ) ) -RRB- cord-009571-mygj2nd4 1330 25 . . . cord-009571-mygj2nd4 1331 1 In in IN cord-009571-mygj2nd4 1331 2 this this DT cord-009571-mygj2nd4 1331 3 study study NN cord-009571-mygj2nd4 1331 4 , , , cord-009571-mygj2nd4 1331 5 a a DT cord-009571-mygj2nd4 1331 6 complement complement NN cord-009571-mygj2nd4 1331 7 - - HYPH cord-009571-mygj2nd4 1331 8 dependent dependent JJ cord-009571-mygj2nd4 1331 9 hemolytic hemolytic JJ cord-009571-mygj2nd4 1331 10 assay assay NN cord-009571-mygj2nd4 1331 11 was be VBD cord-009571-mygj2nd4 1331 12 used use VBN cord-009571-mygj2nd4 1331 13 to to TO cord-009571-mygj2nd4 1331 14 determine determine VB cord-009571-mygj2nd4 1331 15 the the DT cord-009571-mygj2nd4 1331 16 presence presence NN cord-009571-mygj2nd4 1331 17 of of IN cord-009571-mygj2nd4 1331 18 hidden hide VBN cord-009571-mygj2nd4 1331 19 RF rf NN cord-009571-mygj2nd4 1331 20 . . . cord-009571-mygj2nd4 1332 1 Sera Sera NNP cord-009571-mygj2nd4 1332 2 of of IN cord-009571-mygj2nd4 1332 3 59 59 CD cord-009571-mygj2nd4 1332 4 children child NNS cord-009571-mygj2nd4 1332 5 with with IN cord-009571-mygj2nd4 1332 6 seronegative seronegative JJ cord-009571-mygj2nd4 1332 7 JRA JRA NNP cord-009571-mygj2nd4 1332 8 , , , cord-009571-mygj2nd4 1332 9 2 2 CD cord-009571-mygj2nd4 1332 10 with with IN cord-009571-mygj2nd4 1332 11 seropositive seropositive JJ cord-009571-mygj2nd4 1332 12 JRA JRA NNP cord-009571-mygj2nd4 1332 13 , , , cord-009571-mygj2nd4 1332 14 7 7 CD cord-009571-mygj2nd4 1332 15 children child NNS cord-009571-mygj2nd4 1332 16 with with IN cord-009571-mygj2nd4 1332 17 connective connective JJ cord-009571-mygj2nd4 1332 18 tissue tissue NN cord-009571-mygj2nd4 1332 19 diseases disease NNS cord-009571-mygj2nd4 1332 20 , , , cord-009571-mygj2nd4 1332 21 3 3 CD cord-009571-mygj2nd4 1332 22 with with IN cord-009571-mygj2nd4 1332 23 leukemia leukemia NN cord-009571-mygj2nd4 1332 24 , , , cord-009571-mygj2nd4 1332 25 and and CC cord-009571-mygj2nd4 1332 26 12 12 CD cord-009571-mygj2nd4 1332 27 normal normal JJ cord-009571-mygj2nd4 1332 28 children child NNS cord-009571-mygj2nd4 1332 29 were be VBD cord-009571-mygj2nd4 1332 30 separated separate VBN cord-009571-mygj2nd4 1332 31 by by IN cord-009571-mygj2nd4 1332 32 gel gel NN cord-009571-mygj2nd4 1332 33 filtration filtration NN cord-009571-mygj2nd4 1332 34 at at IN cord-009571-mygj2nd4 1332 35 pH pH NNP cord-009571-mygj2nd4 1332 36 4.0 4.0 CD cord-009571-mygj2nd4 1332 37 to to TO cord-009571-mygj2nd4 1332 38 obtain obtain VB cord-009571-mygj2nd4 1332 39 the the DT cord-009571-mygj2nd4 1332 40 IgM IgM NNP cord-009571-mygj2nd4 1332 41 - - HYPH cord-009571-mygj2nd4 1332 42 containing contain VBG cord-009571-mygj2nd4 1332 43 fraction fraction NN cord-009571-mygj2nd4 1332 44 . . . cord-009571-mygj2nd4 1333 1 These these DT cord-009571-mygj2nd4 1333 2 IgM IgM NNP cord-009571-mygj2nd4 1333 3 fractions fraction NNS cord-009571-mygj2nd4 1333 4 were be VBD cord-009571-mygj2nd4 1333 5 subjected subject VBN cord-009571-mygj2nd4 1333 6 to to IN cord-009571-mygj2nd4 1333 7 the the DT cord-009571-mygj2nd4 1333 8 complement complement NN cord-009571-mygj2nd4 1333 9 - - HYPH cord-009571-mygj2nd4 1333 10 dependent dependent JJ cord-009571-mygj2nd4 1333 11 hemolytic hemolytic JJ cord-009571-mygj2nd4 1333 12 assay assay NN cord-009571-mygj2nd4 1333 13 in in IN cord-009571-mygj2nd4 1333 14 which which WDT cord-009571-mygj2nd4 1333 15 sheep sheep NN cord-009571-mygj2nd4 1333 16 erythrocytes erythrocyte NNS cord-009571-mygj2nd4 1333 17 ( ( -LRB- cord-009571-mygj2nd4 1333 18 SRBC SRBC NNP cord-009571-mygj2nd4 1333 19 ) ) -RRB- cord-009571-mygj2nd4 1333 20 are be VBP cord-009571-mygj2nd4 1333 21 coated coat VBN cord-009571-mygj2nd4 1333 22 with with IN cord-009571-mygj2nd4 1333 23 reduced reduce VBN cord-009571-mygj2nd4 1333 24 , , , cord-009571-mygj2nd4 1333 25 alkylated alkylate VBN cord-009571-mygj2nd4 1333 26 , , , cord-009571-mygj2nd4 1333 27 and and CC cord-009571-mygj2nd4 1333 28 acid acid NN cord-009571-mygj2nd4 1333 29 - - HYPH cord-009571-mygj2nd4 1333 30 treated treat VBN cord-009571-mygj2nd4 1333 31 rabbit rabbit NN cord-009571-mygj2nd4 1333 32 IgG IgG NNP cord-009571-mygj2nd4 1333 33 anti anti NNP cord-009571-mygj2nd4 1333 34 - - NNP cord-009571-mygj2nd4 1333 35 SRBC SRBC NNP cord-009571-mygj2nd4 1333 36 antibody antibody NN cord-009571-mygj2nd4 1333 37 and and CC cord-009571-mygj2nd4 1333 38 are be VBP cord-009571-mygj2nd4 1333 39 hemolyzed hemolyze VBN cord-009571-mygj2nd4 1333 40 by by IN cord-009571-mygj2nd4 1333 41 guinea guinea NN cord-009571-mygj2nd4 1333 42 pig pig NN cord-009571-mygj2nd4 1333 43 complement complement NN cord-009571-mygj2nd4 1333 44 in in IN cord-009571-mygj2nd4 1333 45 the the DT cord-009571-mygj2nd4 1333 46 presence presence NN cord-009571-mygj2nd4 1333 47 of of IN cord-009571-mygj2nd4 1333 48 19s 19s NNPS cord-009571-mygj2nd4 1333 49 IgM IgM NNP cord-009571-mygj2nd4 1333 50 RF RF NNP cord-009571-mygj2nd4 1333 51 . . . cord-009571-mygj2nd4 1334 1 Thirty thirty CD cord-009571-mygj2nd4 1334 2 - - HYPH cord-009571-mygj2nd4 1334 3 seven seven CD cord-009571-mygj2nd4 1334 4 of of IN cord-009571-mygj2nd4 1334 5 61 61 CD cord-009571-mygj2nd4 1334 6 patients patient NNS cord-009571-mygj2nd4 1334 7 with with IN cord-009571-mygj2nd4 1334 8 JRA JRA NNP cord-009571-mygj2nd4 1334 9 , , , cord-009571-mygj2nd4 1334 10 of of IN cord-009571-mygj2nd4 1334 11 which which WDT cord-009571-mygj2nd4 1334 12 23 23 CD cord-009571-mygj2nd4 1334 13 of of IN cord-009571-mygj2nd4 1334 14 33 33 CD cord-009571-mygj2nd4 1334 15 polyarticular polyarticular JJ cord-009571-mygj2nd4 1334 16 JRA JRA NNP cord-009571-mygj2nd4 1334 17 , , , cord-009571-mygj2nd4 1334 18 12 12 CD cord-009571-mygj2nd4 1334 19 of of IN cord-009571-mygj2nd4 1334 20 21 21 CD cord-009571-mygj2nd4 1334 21 pauciarticular pauciarticular NNP cord-009571-mygj2nd4 1334 22 JRA JRA NNP cord-009571-mygj2nd4 1334 23 , , , cord-009571-mygj2nd4 1334 24 and and CC cord-009571-mygj2nd4 1334 25 2 2 CD cord-009571-mygj2nd4 1334 26 of of IN cord-009571-mygj2nd4 1334 27 7 7 CD cord-009571-mygj2nd4 1334 28 systemic systemic JJ cord-009571-mygj2nd4 1334 29 JRA JRA NNP cord-009571-mygj2nd4 1334 30 , , , cord-009571-mygj2nd4 1334 31 had have VBD cord-009571-mygj2nd4 1334 32 titers titer NNS cord-009571-mygj2nd4 1335 1 > > XX cord-009571-mygj2nd4 1336 1 1 1 LS cord-009571-mygj2nd4 1336 2 : : SYM cord-009571-mygj2nd4 1336 3 16 16 CD cord-009571-mygj2nd4 1336 4 . . . cord-009571-mygj2nd4 1337 1 None none NN cord-009571-mygj2nd4 1337 2 of of IN cord-009571-mygj2nd4 1337 3 12 12 CD cord-009571-mygj2nd4 1337 4 normal normal JJ cord-009571-mygj2nd4 1337 5 controls control NNS cord-009571-mygj2nd4 1337 6 and and CC cord-009571-mygj2nd4 1337 7 only only RB cord-009571-mygj2nd4 1337 8 1 1 CD cord-009571-mygj2nd4 1337 9 of of IN cord-009571-mygj2nd4 1337 10 10 10 CD cord-009571-mygj2nd4 1337 11 disease disease NN cord-009571-mygj2nd4 1337 12 controls control NNS cord-009571-mygj2nd4 1337 13 had have VBD cord-009571-mygj2nd4 1337 14 titers titer NNS cord-009571-mygj2nd4 1337 15 > > XX cord-009571-mygj2nd4 1337 16 1 1 CD cord-009571-mygj2nd4 1337 17 : : : cord-009571-mygj2nd4 1337 18 16 16 CD cord-009571-mygj2nd4 1337 19 . . . cord-009571-mygj2nd4 1338 1 The the DT cord-009571-mygj2nd4 1338 2 median median JJ cord-009571-mygj2nd4 1338 3 titer titer NN cord-009571-mygj2nd4 1338 4 of of IN cord-009571-mygj2nd4 1338 5 all all DT cord-009571-mygj2nd4 1338 6 JRA JRA NNP cord-009571-mygj2nd4 1338 7 patients patient NNS cord-009571-mygj2nd4 1338 8 was be VBD cord-009571-mygj2nd4 1338 9 1 1 CD cord-009571-mygj2nd4 1338 10 : : SYM cord-009571-mygj2nd4 1338 11 42 42 CD cord-009571-mygj2nd4 1338 12 and and CC cord-009571-mygj2nd4 1338 13 healthy healthy JJ cord-009571-mygj2nd4 1338 14 and and CC cord-009571-mygj2nd4 1338 15 disease disease NN cord-009571-mygj2nd4 1338 16 controls control NNS cord-009571-mygj2nd4 1338 17 , , , cord-009571-mygj2nd4 1338 18 1 1 CD cord-009571-mygj2nd4 1338 19 : : SYM cord-009571-mygj2nd4 1338 20 7 7 CD cord-009571-mygj2nd4 1338 21 . . . cord-009571-mygj2nd4 1339 1 Estimates estimate NNS cord-009571-mygj2nd4 1339 2 of of IN cord-009571-mygj2nd4 1339 3 the the DT cord-009571-mygj2nd4 1339 4 significance significance NN cord-009571-mygj2nd4 1339 5 of of IN cord-009571-mygj2nd4 1339 6 the the DT cord-009571-mygj2nd4 1339 7 differences difference NNS cord-009571-mygj2nd4 1339 8 between between IN cord-009571-mygj2nd4 1339 9 the the DT cord-009571-mygj2nd4 1339 10 median median JJ cord-009571-mygj2nd4 1339 11 titers titer NNS cord-009571-mygj2nd4 1339 12 of of IN cord-009571-mygj2nd4 1339 13 JRA JRA NNP cord-009571-mygj2nd4 1339 14 patients patient NNS cord-009571-mygj2nd4 1339 15 and and CC cord-009571-mygj2nd4 1339 16 of of IN cord-009571-mygj2nd4 1339 17 the the DT cord-009571-mygj2nd4 1339 18 controls control NNS cord-009571-mygj2nd4 1339 19 were be VBD cord-009571-mygj2nd4 1339 20 obtained obtain VBN cord-009571-mygj2nd4 1339 21 by by IN cord-009571-mygj2nd4 1339 22 Mann Mann NNP cord-009571-mygj2nd4 1339 23 - - HYPH cord-009571-mygj2nd4 1339 24 Whitney Whitney NNP cord-009571-mygj2nd4 1339 25 analysis analysis NN cord-009571-mygj2nd4 1339 26 . . . cord-009571-mygj2nd4 1340 1 They -PRON- PRP cord-009571-mygj2nd4 1340 2 were be VBD cord-009571-mygj2nd4 1340 3 significant significant JJ cord-009571-mygj2nd4 1340 4 at at IN cord-009571-mygj2nd4 1340 5 P p NN cord-009571-mygj2nd4 1340 6 < < XX cord-009571-mygj2nd4 1340 7 0.001 0.001 CD cord-009571-mygj2nd4 1340 8 . . . cord-009571-mygj2nd4 1341 1 When when WRB cord-009571-mygj2nd4 1341 2 data datum NNS cord-009571-mygj2nd4 1341 3 from from IN cord-009571-mygj2nd4 1341 4 patients patient NNS cord-009571-mygj2nd4 1341 5 with with IN cord-009571-mygj2nd4 1341 6 active active JJ cord-009571-mygj2nd4 1341 7 disease disease NN cord-009571-mygj2nd4 1341 8 were be VBD cord-009571-mygj2nd4 1341 9 analyzed analyze VBN cord-009571-mygj2nd4 1341 10 separately separately RB cord-009571-mygj2nd4 1341 11 , , , cord-009571-mygj2nd4 1341 12 the the DT cord-009571-mygj2nd4 1341 13 median median JJ cord-009571-mygj2nd4 1341 14 titers titer NNS cord-009571-mygj2nd4 1341 15 for for IN cord-009571-mygj2nd4 1341 16 polyarticular polyarticular JJ cord-009571-mygj2nd4 1341 17 JRA JRA NNP cord-009571-mygj2nd4 1341 18 were be VBD cord-009571-mygj2nd4 1341 19 1:97 1:97 CD cord-009571-mygj2nd4 1341 20 , , , cord-009571-mygj2nd4 1341 21 pauciarticular pauciarticular NNP cord-009571-mygj2nd4 1341 22 1:91 1:91 CD cord-009571-mygj2nd4 1341 23 , , , cord-009571-mygj2nd4 1341 24 and and CC cord-009571-mygj2nd4 1341 25 systemic systemic JJ cord-009571-mygj2nd4 1341 26 1:23 1:23 CD cord-009571-mygj2nd4 1341 27 . . . cord-009571-mygj2nd4 1342 1 Patients patient NNS cord-009571-mygj2nd4 1342 2 with with IN cord-009571-mygj2nd4 1342 3 inactive inactive JJ cord-009571-mygj2nd4 1342 4 disease disease NN cord-009571-mygj2nd4 1342 5 did do VBD cord-009571-mygj2nd4 1342 6 not not RB cord-009571-mygj2nd4 1342 7 have have VB cord-009571-mygj2nd4 1342 8 significantly significantly RB cord-009571-mygj2nd4 1342 9 different different JJ cord-009571-mygj2nd4 1342 10 titers titer NNS cord-009571-mygj2nd4 1342 11 from from IN cord-009571-mygj2nd4 1342 12 controls control NNS cord-009571-mygj2nd4 1342 13 . . . cord-009571-mygj2nd4 1343 1 The the DT cord-009571-mygj2nd4 1343 2 active active JJ cord-009571-mygj2nd4 1343 3 polyarticular polyarticular NN cord-009571-mygj2nd4 1343 4 and and CC cord-009571-mygj2nd4 1343 5 pauciarticular pauciarticular JJ cord-009571-mygj2nd4 1343 6 values value NNS cord-009571-mygj2nd4 1343 7 were be VBD cord-009571-mygj2nd4 1343 8 significant significant JJ cord-009571-mygj2nd4 1343 9 at at IN cord-009571-mygj2nd4 1343 10 P p NN cord-009571-mygj2nd4 1343 11 < < XX cord-009571-mygj2nd4 1343 12 0.001 0.001 CD cord-009571-mygj2nd4 1343 13 and and CC cord-009571-mygj2nd4 1343 14 P p NN cord-009571-mygj2nd4 1343 15 < < XX cord-009571-mygj2nd4 1343 16 0.005 0.005 XX cord-009571-mygj2nd4 1343 17 . . . cord-009571-mygj2nd4 1344 1 These these DT cord-009571-mygj2nd4 1344 2 results result NNS cord-009571-mygj2nd4 1344 3 demonstrate demonstrate VBP cord-009571-mygj2nd4 1344 4 : : : cord-009571-mygj2nd4 1344 5 ( ( -LRB- cord-009571-mygj2nd4 1344 6 1 1 CD cord-009571-mygj2nd4 1344 7 ) ) -RRB- cord-009571-mygj2nd4 1344 8 59 59 CD cord-009571-mygj2nd4 1344 9 % % NN cord-009571-mygj2nd4 1344 10 of of IN cord-009571-mygj2nd4 1344 11 seronegative seronegative JJ cord-009571-mygj2nd4 1344 12 JRA JRA NNP cord-009571-mygj2nd4 1344 13 patients patient NNS cord-009571-mygj2nd4 1344 14 have have VBP cord-009571-mygj2nd4 1344 15 hidden hide VBN cord-009571-mygj2nd4 1344 16 RF rf NN cord-009571-mygj2nd4 1344 17 by by IN cord-009571-mygj2nd4 1344 18 this this DT cord-009571-mygj2nd4 1344 19 procedure procedure NN cord-009571-mygj2nd4 1344 20 ; ; : cord-009571-mygj2nd4 1344 21 ( ( -LRB- cord-009571-mygj2nd4 1344 22 2 2 LS cord-009571-mygj2nd4 1344 23 ) ) -RRB- cord-009571-mygj2nd4 1344 24 the the DT cord-009571-mygj2nd4 1344 25 hemolytic hemolytic JJ cord-009571-mygj2nd4 1344 26 assay assay NN cord-009571-mygj2nd4 1344 27 is be VBZ cord-009571-mygj2nd4 1344 28 more more RBR cord-009571-mygj2nd4 1344 29 sensitive sensitive JJ cord-009571-mygj2nd4 1344 30 than than IN cord-009571-mygj2nd4 1344 31 the the DT cord-009571-mygj2nd4 1344 32 LFT LFT NNP cord-009571-mygj2nd4 1344 33 or or CC cord-009571-mygj2nd4 1344 34 sheep sheep NN cord-009571-mygj2nd4 1344 35 cell cell NN cord-009571-mygj2nd4 1344 36 agglutination agglutination NN cord-009571-mygj2nd4 1344 37 tests test NNS cord-009571-mygj2nd4 1344 38 ( ( -LRB- cord-009571-mygj2nd4 1344 39 SCAT scat NN cord-009571-mygj2nd4 1344 40 ) ) -RRB- cord-009571-mygj2nd4 1344 41 in in IN cord-009571-mygj2nd4 1344 42 determining determine VBG cord-009571-mygj2nd4 1344 43 the the DT cord-009571-mygj2nd4 1344 44 presence presence NN cord-009571-mygj2nd4 1344 45 of of IN cord-009571-mygj2nd4 1344 46 hidden hide VBN cord-009571-mygj2nd4 1344 47 RF rf NN cord-009571-mygj2nd4 1344 48 in in IN cord-009571-mygj2nd4 1344 49 JRA JRA NNP cord-009571-mygj2nd4 1344 50 ; ; : cord-009571-mygj2nd4 1344 51 and and CC cord-009571-mygj2nd4 1344 52 ( ( -LRB- cord-009571-mygj2nd4 1344 53 3 3 LS cord-009571-mygj2nd4 1344 54 ) ) -RRB- cord-009571-mygj2nd4 1344 55 activity activity NN cord-009571-mygj2nd4 1344 56 of of IN cord-009571-mygj2nd4 1344 57 disease disease NN cord-009571-mygj2nd4 1344 58 correlated correlate VBN cord-009571-mygj2nd4 1344 59 with with IN cord-009571-mygj2nd4 1344 60 higher high JJR cord-009571-mygj2nd4 1344 61 titers titer NNS cord-009571-mygj2nd4 1344 62 in in IN cord-009571-mygj2nd4 1344 63 the the DT cord-009571-mygj2nd4 1344 64 hemolytic hemolytic JJ cord-009571-mygj2nd4 1344 65 assay assay NN cord-009571-mygj2nd4 1344 66 , , , cord-009571-mygj2nd4 1344 67 and and CC cord-009571-mygj2nd4 1344 68 the the DT cord-009571-mygj2nd4 1344 69 assay assay NN cord-009571-mygj2nd4 1344 70 was be VBD cord-009571-mygj2nd4 1344 71 superior superior JJ cord-009571-mygj2nd4 1344 72 to to IN cord-009571-mygj2nd4 1344 73 the the DT cord-009571-mygj2nd4 1344 74 LFT LFT NNP cord-009571-mygj2nd4 1344 75 or or CC cord-009571-mygj2nd4 1344 76 SCAT scat NN cord-009571-mygj2nd4 1344 77 as as IN cord-009571-mygj2nd4 1344 78 an an DT cord-009571-mygj2nd4 1344 79 indicator indicator NN cord-009571-mygj2nd4 1344 80 of of IN cord-009571-mygj2nd4 1344 81 disease disease NN cord-009571-mygj2nd4 1344 82 activity activity NN cord-009571-mygj2nd4 1344 83 . . . cord-009571-mygj2nd4 1345 1 This this DT cord-009571-mygj2nd4 1345 2 study study NN cord-009571-mygj2nd4 1345 3 was be VBD cord-009571-mygj2nd4 1345 4 devised devise VBN cord-009571-mygj2nd4 1345 5 to to TO cord-009571-mygj2nd4 1345 6 answer answer VB cord-009571-mygj2nd4 1345 7 in in IN cord-009571-mygj2nd4 1345 8 relation relation NN cord-009571-mygj2nd4 1345 9 to to IN cord-009571-mygj2nd4 1345 10 articular articular JJ cord-009571-mygj2nd4 1345 11 cartilage cartilage NN cord-009571-mygj2nd4 1345 12 proteoglycans proteoglycan NNS cord-009571-mygj2nd4 1345 13 ( ( -LRB- cord-009571-mygj2nd4 1345 14 PGs pg NNS cord-009571-mygj2nd4 1345 15 ) ) -RRB- cord-009571-mygj2nd4 1345 16 whether whether IN cord-009571-mygj2nd4 1345 17 degradation degradation NN cord-009571-mygj2nd4 1345 18 products product NNS cord-009571-mygj2nd4 1345 19 or or CC cord-009571-mygj2nd4 1345 20 products product NNS cord-009571-mygj2nd4 1345 21 of of IN cord-009571-mygj2nd4 1345 22 incomplete incomplete JJ cord-009571-mygj2nd4 1345 23 synthesis synthesis NN cord-009571-mygj2nd4 1345 24 are be VBP cord-009571-mygj2nd4 1345 25 detectable detectable JJ cord-009571-mygj2nd4 1345 26 in in IN cord-009571-mygj2nd4 1345 27 the the DT cord-009571-mygj2nd4 1345 28 earliest early JJS cord-009571-mygj2nd4 1345 29 pathological pathological JJ cord-009571-mygj2nd4 1345 30 lesions lesion NNS cord-009571-mygj2nd4 1345 31 of of IN cord-009571-mygj2nd4 1345 32 this this DT cord-009571-mygj2nd4 1345 33 rabbit rabbit NN cord-009571-mygj2nd4 1345 34 model model NN cord-009571-mygj2nd4 1345 35 of of IN cord-009571-mygj2nd4 1345 36 osteoarthritis osteoarthritis NN cord-009571-mygj2nd4 1345 37 . . . cord-009571-mygj2nd4 1346 1 An an DT cord-009571-mygj2nd4 1346 2 ultramicro ultramicro NN cord-009571-mygj2nd4 1346 3 transport transport NN cord-009571-mygj2nd4 1346 4 method method NN cord-009571-mygj2nd4 1346 5 for for IN cord-009571-mygj2nd4 1346 6 obtaining obtain VBG cord-009571-mygj2nd4 1346 7 S S NNP cord-009571-mygj2nd4 1346 8 value value NN cord-009571-mygj2nd4 1346 9 polydisperse polydisperse JJ cord-009571-mygj2nd4 1346 10 profiles profile NNS cord-009571-mygj2nd4 1346 11 for for IN cord-009571-mygj2nd4 1346 12 PG PG NNP cord-009571-mygj2nd4 1346 13 aggregates aggregate NNS cord-009571-mygj2nd4 1346 14 ( ( -LRB- cord-009571-mygj2nd4 1346 15 PGagg pgagg CD cord-009571-mygj2nd4 1346 16 ) ) -RRB- cord-009571-mygj2nd4 1346 17 and and CC cord-009571-mygj2nd4 1346 18 subunits subunit NNS cord-009571-mygj2nd4 1346 19 ( ( -LRB- cord-009571-mygj2nd4 1346 20 PGS PGS NNP cord-009571-mygj2nd4 1346 21 ) ) -RRB- cord-009571-mygj2nd4 1346 22 , , , cord-009571-mygj2nd4 1346 23 and and CC cord-009571-mygj2nd4 1346 24 miniaturized miniaturize VBN cord-009571-mygj2nd4 1346 25 extraction extraction NN cord-009571-mygj2nd4 1346 26 , , , cord-009571-mygj2nd4 1346 27 dialysis dialysis NN cord-009571-mygj2nd4 1346 28 and and CC cord-009571-mygj2nd4 1346 29 CsCl CsCl NNP cord-009571-mygj2nd4 1346 30 density density NN cord-009571-mygj2nd4 1346 31 gradient gradient NN cord-009571-mygj2nd4 1346 32 ultracentrifugation ultracentrifugation NN cord-009571-mygj2nd4 1346 33 techniques technique NNS cord-009571-mygj2nd4 1346 34 have have VBP cord-009571-mygj2nd4 1346 35 allowed allow VBN cord-009571-mygj2nd4 1346 36 study study NN cord-009571-mygj2nd4 1346 37 of of IN cord-009571-mygj2nd4 1346 38 these these DT cord-009571-mygj2nd4 1346 39 PGs pg NNS cord-009571-mygj2nd4 1346 40 and and CC cord-009571-mygj2nd4 1346 41 various various JJ cord-009571-mygj2nd4 1346 42 PG PG NNP cord-009571-mygj2nd4 1346 43 products product NNS cord-009571-mygj2nd4 1346 44 within within IN cord-009571-mygj2nd4 1346 45 the the DT cord-009571-mygj2nd4 1346 46 S S NNP cord-009571-mygj2nd4 1346 47 value value NN cord-009571-mygj2nd4 1346 48 range range NN cord-009571-mygj2nd4 1346 49 of of IN cord-009571-mygj2nd4 1346 50 1 1 CD cord-009571-mygj2nd4 1346 51 - - SYM cord-009571-mygj2nd4 1346 52 200 200 CD cord-009571-mygj2nd4 1346 53 from from IN cord-009571-mygj2nd4 1346 54 histologically histologically RB cord-009571-mygj2nd4 1346 55 defined define VBN cord-009571-mygj2nd4 1346 56 sites site NNS cord-009571-mygj2nd4 1346 57 . . . cord-009571-mygj2nd4 1347 1 Thirty thirty CD cord-009571-mygj2nd4 1347 2 New New NNP cord-009571-mygj2nd4 1347 3 Zealand Zealand NNP cord-009571-mygj2nd4 1347 4 white white JJ cord-009571-mygj2nd4 1347 5 rabbits rabbit NNS cord-009571-mygj2nd4 1347 6 ( ( -LRB- cord-009571-mygj2nd4 1347 7 weighing weigh VBG cord-009571-mygj2nd4 1347 8 2 2 CD cord-009571-mygj2nd4 1347 9 - - SYM cord-009571-mygj2nd4 1347 10 2.5 2.5 CD cord-009571-mygj2nd4 1347 11 kg kg NNS cord-009571-mygj2nd4 1347 12 ) ) -RRB- cord-009571-mygj2nd4 1347 13 were be VBD cord-009571-mygj2nd4 1347 14 subjected subject VBN cord-009571-mygj2nd4 1347 15 to to IN cord-009571-mygj2nd4 1347 16 partial partial JJ cord-009571-mygj2nd4 1347 17 medial medial JJ cord-009571-mygj2nd4 1347 18 meniscectomy meniscectomy NN cord-009571-mygj2nd4 1347 19 and and CC cord-009571-mygj2nd4 1347 20 killed kill VBD cord-009571-mygj2nd4 1347 21 10 10 CD cord-009571-mygj2nd4 1347 22 - - SYM cord-009571-mygj2nd4 1347 23 12 12 CD cord-009571-mygj2nd4 1347 24 weeks week NNS cord-009571-mygj2nd4 1347 25 postoperatively postoperatively RB cord-009571-mygj2nd4 1347 26 under under IN cord-009571-mygj2nd4 1347 27 Nembutal Nembutal NNP cord-009571-mygj2nd4 1347 28 anesthesia anesthesia NN cord-009571-mygj2nd4 1347 29 . . . cord-009571-mygj2nd4 1348 1 Micro Micro NNP cord-009571-mygj2nd4 1348 2 - - HYPH cord-009571-mygj2nd4 1348 3 dissected dissect VBN cord-009571-mygj2nd4 1348 4 medial medial JJ cord-009571-mygj2nd4 1348 5 femoral femoral JJ cord-009571-mygj2nd4 1348 6 condyle condyle NN cord-009571-mygj2nd4 1348 7 samples sample NNS cord-009571-mygj2nd4 1348 8 included include VBD cord-009571-mygj2nd4 1348 9 1 1 CD cord-009571-mygj2nd4 1348 10 ) ) -RRB- cord-009571-mygj2nd4 1348 11 ulceration ulceration NN cord-009571-mygj2nd4 1348 12 , , , cord-009571-mygj2nd4 1348 13 2 2 CD cord-009571-mygj2nd4 1348 14 ) ) -RRB- cord-009571-mygj2nd4 1348 15 1 1 CD cord-009571-mygj2nd4 1348 16 mm mm NN cord-009571-mygj2nd4 1348 17 rim rim NN cord-009571-mygj2nd4 1348 18 surrounding surround VBG cord-009571-mygj2nd4 1348 19 the the DT cord-009571-mygj2nd4 1348 20 ulcer ulcer NN cord-009571-mygj2nd4 1348 21 often often RB cord-009571-mygj2nd4 1348 22 with with IN cord-009571-mygj2nd4 1348 23 fibrillation fibrillation NN cord-009571-mygj2nd4 1348 24 , , , cord-009571-mygj2nd4 1348 25 and and CC cord-009571-mygj2nd4 1348 26 3 3 LS cord-009571-mygj2nd4 1348 27 ) ) -RRB- cord-009571-mygj2nd4 1348 28 cartilage cartilage NN cord-009571-mygj2nd4 1348 29 from from IN cord-009571-mygj2nd4 1348 30 the the DT cord-009571-mygj2nd4 1348 31 medial medial JJ cord-009571-mygj2nd4 1348 32 and and CC cord-009571-mygj2nd4 1348 33 lateral lateral JJ cord-009571-mygj2nd4 1348 34 femoral femoral JJ cord-009571-mygj2nd4 1348 35 condyle condyle NN cord-009571-mygj2nd4 1348 36 which which WDT cord-009571-mygj2nd4 1348 37 occasionally occasionally RB cord-009571-mygj2nd4 1348 38 revealed reveal VBD cord-009571-mygj2nd4 1348 39 fibrillation fibrillation NN cord-009571-mygj2nd4 1348 40 but but CC cord-009571-mygj2nd4 1348 41 usually usually RB cord-009571-mygj2nd4 1348 42 appeared appear VBD cord-009571-mygj2nd4 1348 43 to to TO cord-009571-mygj2nd4 1348 44 be be VB cord-009571-mygj2nd4 1348 45 normal normal JJ cord-009571-mygj2nd4 1348 46 . . . cord-009571-mygj2nd4 1349 1 Amounts amount NNS cord-009571-mygj2nd4 1349 2 of of IN cord-009571-mygj2nd4 1349 3 cartilage cartilage NN cord-009571-mygj2nd4 1349 4 equivalent equivalent JJ cord-009571-mygj2nd4 1349 5 to to IN cord-009571-mygj2nd4 1349 6 3 3 CD cord-009571-mygj2nd4 1349 7 ) ) -RRB- cord-009571-mygj2nd4 1349 8 above above RB cord-009571-mygj2nd4 1349 9 were be VBD cord-009571-mygj2nd4 1349 10 obtained obtain VBN cord-009571-mygj2nd4 1349 11 from from IN cord-009571-mygj2nd4 1349 12 the the DT cord-009571-mygj2nd4 1349 13 contralateral contralateral NN cord-009571-mygj2nd4 1349 14 ( ( -LRB- cord-009571-mygj2nd4 1349 15 left left JJ cord-009571-mygj2nd4 1349 16 ) ) -RRB- cord-009571-mygj2nd4 1349 17 knee knee NN cord-009571-mygj2nd4 1349 18 for for IN cord-009571-mygj2nd4 1349 19 use use NN cord-009571-mygj2nd4 1349 20 as as IN cord-009571-mygj2nd4 1349 21 a a DT cord-009571-mygj2nd4 1349 22 primary primary JJ cord-009571-mygj2nd4 1349 23 control control NN cord-009571-mygj2nd4 1349 24 and and CC cord-009571-mygj2nd4 1349 25 from from IN cord-009571-mygj2nd4 1349 26 sham sham NNP cord-009571-mygj2nd4 1349 27 operated operate VBD cord-009571-mygj2nd4 1349 28 ( ( -LRB- cord-009571-mygj2nd4 1349 29 right right UH cord-009571-mygj2nd4 1349 30 ) ) -RRB- cord-009571-mygj2nd4 1349 31 knees knee NNS cord-009571-mygj2nd4 1349 32 for for IN cord-009571-mygj2nd4 1349 33 use use NN cord-009571-mygj2nd4 1349 34 as as IN cord-009571-mygj2nd4 1349 35 a a DT cord-009571-mygj2nd4 1349 36 second second JJ cord-009571-mygj2nd4 1349 37 control control NN cord-009571-mygj2nd4 1349 38 . . . cord-009571-mygj2nd4 1350 1 The the DT cord-009571-mygj2nd4 1350 2 cartilage cartilage NN cord-009571-mygj2nd4 1350 3 from from IN cord-009571-mygj2nd4 1350 4 4 4 CD cord-009571-mygj2nd4 1350 5 rabbits rabbit NNS cord-009571-mygj2nd4 1350 6 was be VBD cord-009571-mygj2nd4 1350 7 required require VBN cord-009571-mygj2nd4 1350 8 to to TO cord-009571-mygj2nd4 1350 9 obtain obtain VB cord-009571-mygj2nd4 1350 10 a a DT cord-009571-mygj2nd4 1350 11 pool pool NN cord-009571-mygj2nd4 1350 12 of of IN cord-009571-mygj2nd4 1350 13 10 10 CD cord-009571-mygj2nd4 1350 14 - - SYM cord-009571-mygj2nd4 1350 15 20 20 CD cord-009571-mygj2nd4 1350 16 mg mg NN cord-009571-mygj2nd4 1350 17 wet wet JJ cord-009571-mygj2nd4 1350 18 cartilage cartilage NN cord-009571-mygj2nd4 1350 19 for for IN cord-009571-mygj2nd4 1350 20 each each DT cord-009571-mygj2nd4 1350 21 zone zone NN cord-009571-mygj2nd4 1351 1 1 1 LS cord-009571-mygj2nd4 1351 2 - - SYM cord-009571-mygj2nd4 1351 3 3 3 CD cord-009571-mygj2nd4 1351 4 above above RB cord-009571-mygj2nd4 1351 5 . . . cord-009571-mygj2nd4 1352 1 These these DT cord-009571-mygj2nd4 1352 2 cartilages cartilage NNS cord-009571-mygj2nd4 1352 3 were be VBD cord-009571-mygj2nd4 1352 4 diced dice VBN cord-009571-mygj2nd4 1352 5 and and CC cord-009571-mygj2nd4 1352 6 PGs pg NNS cord-009571-mygj2nd4 1352 7 extracted extract VBD cord-009571-mygj2nd4 1352 8 , , , cord-009571-mygj2nd4 1352 9 dialysed dialyse VBD cord-009571-mygj2nd4 1352 10 , , , cord-009571-mygj2nd4 1352 11 and and CC cord-009571-mygj2nd4 1352 12 partitioned partition VBD cord-009571-mygj2nd4 1352 13 . . . cord-009571-mygj2nd4 1353 1 For for IN cord-009571-mygj2nd4 1353 2 PG PG NNP cord-009571-mygj2nd4 1353 3 extracted extract VBN cord-009571-mygj2nd4 1353 4 with with IN cord-009571-mygj2nd4 1353 5 4.0 4.0 CD cord-009571-mygj2nd4 1353 6 A4 a4 NN cord-009571-mygj2nd4 1353 7 GuCl GuCl NNS cord-009571-mygj2nd4 1353 8 from from IN cord-009571-mygj2nd4 1353 9 left left JJ cord-009571-mygj2nd4 1353 10 femoral femoral JJ cord-009571-mygj2nd4 1353 11 articular articular JJ cord-009571-mygj2nd4 1353 12 cartilage cartilage NN cord-009571-mygj2nd4 1353 13 of of IN cord-009571-mygj2nd4 1353 14 control control NN cord-009571-mygj2nd4 1353 15 knees knee NNS cord-009571-mygj2nd4 1353 16 , , , cord-009571-mygj2nd4 1353 17 the the DT cord-009571-mygj2nd4 1353 18 profile profile NN cord-009571-mygj2nd4 1353 19 shows show VBZ cord-009571-mygj2nd4 1353 20 a a DT cord-009571-mygj2nd4 1353 21 subunit subunit NN cord-009571-mygj2nd4 1353 22 peak peak NN cord-009571-mygj2nd4 1353 23 with with IN cord-009571-mygj2nd4 1353 24 weight weight NN cord-009571-mygj2nd4 1353 25 average average JJ cord-009571-mygj2nd4 1353 26 sediment sediment NN cord-009571-mygj2nd4 1353 27 coefficient coefficient NN cord-009571-mygj2nd4 1353 28 S s NN cord-009571-mygj2nd4 1353 29 ; ; : cord-009571-mygj2nd4 1353 30 O o NN cord-009571-mygj2nd4 1353 31 of of IN cord-009571-mygj2nd4 1353 32 about about RB cord-009571-mygj2nd4 1353 33 16 16 CD cord-009571-mygj2nd4 1353 34 and and CC cord-009571-mygj2nd4 1353 35 an an DT cord-009571-mygj2nd4 1353 36 aggregate aggregate JJ cord-009571-mygj2nd4 1353 37 peak peak NN cord-009571-mygj2nd4 1353 38 extending extend VBG cord-009571-mygj2nd4 1353 39 from from IN cord-009571-mygj2nd4 1353 40 40 40 CD cord-009571-mygj2nd4 1353 41 up up IN cord-009571-mygj2nd4 1353 42 to to IN cord-009571-mygj2nd4 1353 43 120 120 CD cord-009571-mygj2nd4 1353 44 S S NNS cord-009571-mygj2nd4 1353 45 with with IN cord-009571-mygj2nd4 1353 46 an an DT cord-009571-mygj2nd4 1353 47 average average NN cord-009571-mygj2nd4 1353 48 of of IN cord-009571-mygj2nd4 1353 49 62 62 CD cord-009571-mygj2nd4 1353 50 . . . cord-009571-mygj2nd4 1354 1 Similar similar JJ cord-009571-mygj2nd4 1354 2 profile profile NN cord-009571-mygj2nd4 1354 3 data datum NNS cord-009571-mygj2nd4 1354 4 on on IN cord-009571-mygj2nd4 1354 5 the the DT cord-009571-mygj2nd4 1354 6 tibia1 tibia1 NNP cord-009571-mygj2nd4 1354 7 cartilage cartilage NN cord-009571-mygj2nd4 1354 8 provided provide VBD cord-009571-mygj2nd4 1354 9 an an DT cord-009571-mygj2nd4 1354 10 average average JJ cord-009571-mygj2nd4 1354 11 sediment sediment NN cord-009571-mygj2nd4 1354 12 coefficient coefficient NN cord-009571-mygj2nd4 1354 13 of of IN cord-009571-mygj2nd4 1354 14 59 59 CD cord-009571-mygj2nd4 1354 15 . . . cord-009571-mygj2nd4 1355 1 About about RB cord-009571-mygj2nd4 1355 2 1/3 1/3 CD cord-009571-mygj2nd4 1355 3 of of IN cord-009571-mygj2nd4 1355 4 PG PG NNP cord-009571-mygj2nd4 1355 5 was be VBD cord-009571-mygj2nd4 1355 6 in in IN cord-009571-mygj2nd4 1355 7 aggregated aggregate VBN cord-009571-mygj2nd4 1355 8 form form NN cord-009571-mygj2nd4 1355 9 and and CC cord-009571-mygj2nd4 1355 10 the the DT cord-009571-mygj2nd4 1355 11 rest rest NN cord-009571-mygj2nd4 1355 12 PGS PGS NNP cord-009571-mygj2nd4 1355 13 . . . cord-009571-mygj2nd4 1356 1 Interestingly interestingly RB cord-009571-mygj2nd4 1356 2 , , , cord-009571-mygj2nd4 1356 3 the the DT cord-009571-mygj2nd4 1356 4 undissociated undissociated JJ cord-009571-mygj2nd4 1356 5 PGagg PGagg NNP cord-009571-mygj2nd4 1356 6 revealed reveal VBD cord-009571-mygj2nd4 1356 7 an an DT cord-009571-mygj2nd4 1356 8 S S NNP cord-009571-mygj2nd4 1356 9 value value NN cord-009571-mygj2nd4 1356 10 range range NN cord-009571-mygj2nd4 1356 11 of of IN cord-009571-mygj2nd4 1356 12 40 40 CD cord-009571-mygj2nd4 1356 13 - - SYM cord-009571-mygj2nd4 1356 14 180 180 CD cord-009571-mygj2nd4 1356 15 . . . cord-009571-mygj2nd4 1357 1 PGs pg NNS cord-009571-mygj2nd4 1357 2 extracted extract VBD cord-009571-mygj2nd4 1357 3 without without IN cord-009571-mygj2nd4 1357 4 dissociation dissociation NN cord-009571-mygj2nd4 1357 5 in in IN cord-009571-mygj2nd4 1357 6 0.5 0.5 CD cord-009571-mygj2nd4 1357 7 M m CD cord-009571-mygj2nd4 1357 8 GuCl GuCl NNS cord-009571-mygj2nd4 1357 9 gave give VBD cord-009571-mygj2nd4 1357 10 similar similar JJ cord-009571-mygj2nd4 1357 11 data datum NNS cord-009571-mygj2nd4 1357 12 . . . cord-009571-mygj2nd4 1358 1 In in IN cord-009571-mygj2nd4 1358 2 regard regard NN cord-009571-mygj2nd4 1358 3 to to IN cord-009571-mygj2nd4 1358 4 the the DT cord-009571-mygj2nd4 1358 5 profile profile NN cord-009571-mygj2nd4 1358 6 of of IN cord-009571-mygj2nd4 1358 7 S S NNP cord-009571-mygj2nd4 1358 8 values value NNS cord-009571-mygj2nd4 1358 9 of of IN cord-009571-mygj2nd4 1358 10 PGs pg NNS cord-009571-mygj2nd4 1358 11 from from IN cord-009571-mygj2nd4 1358 12 small small JJ cord-009571-mygj2nd4 1358 13 ulcers ulcer NNS cord-009571-mygj2nd4 1358 14 , , , cord-009571-mygj2nd4 1358 15 the the DT cord-009571-mygj2nd4 1358 16 weight weight NN cord-009571-mygj2nd4 1358 17 average average JJ cord-009571-mygj2nd4 1358 18 sediment sediment NN cord-009571-mygj2nd4 1358 19 coefficent coefficent NN cord-009571-mygj2nd4 1358 20 S s NN cord-009571-mygj2nd4 1358 21 : : : cord-009571-mygj2nd4 1358 22 O o NN cord-009571-mygj2nd4 1358 23 of of IN cord-009571-mygj2nd4 1358 24 the the DT cord-009571-mygj2nd4 1358 25 peak peak NN cord-009571-mygj2nd4 1358 26 was be VBD cord-009571-mygj2nd4 1358 27 16 16 CD cord-009571-mygj2nd4 1358 28 . . . cord-009571-mygj2nd4 1359 1 Peaks peak NNS cord-009571-mygj2nd4 1359 2 indicative indicative JJ cord-009571-mygj2nd4 1359 3 of of IN cord-009571-mygj2nd4 1359 4 PG PG NNP cord-009571-mygj2nd4 1359 5 products product NNS cord-009571-mygj2nd4 1359 6 with with IN cord-009571-mygj2nd4 1359 7 lesser less JJR cord-009571-mygj2nd4 1359 8 values value NNS cord-009571-mygj2nd4 1359 9 were be VBD cord-009571-mygj2nd4 1359 10 found find VBN cord-009571-mygj2nd4 1359 11 in in IN cord-009571-mygj2nd4 1359 12 3 3 CD cord-009571-mygj2nd4 1359 13 pooled pool VBN cord-009571-mygj2nd4 1359 14 samples sample NNS cord-009571-mygj2nd4 1359 15 with with IN cord-009571-mygj2nd4 1359 16 large large JJ cord-009571-mygj2nd4 1359 17 ulcerations ulceration NNS cord-009571-mygj2nd4 1359 18 . . . cord-009571-mygj2nd4 1360 1 A a DT cord-009571-mygj2nd4 1360 2 similar similar JJ cord-009571-mygj2nd4 1360 3 study study NN cord-009571-mygj2nd4 1360 4 run run NN cord-009571-mygj2nd4 1360 5 after after IN cord-009571-mygj2nd4 1360 6 isolation isolation NN cord-009571-mygj2nd4 1360 7 of of IN cord-009571-mygj2nd4 1360 8 PGS PGS NNP cord-009571-mygj2nd4 1360 9 in in IN cord-009571-mygj2nd4 1360 10 a a DT cord-009571-mygj2nd4 1360 11 dissociative dissociative JJ cord-009571-mygj2nd4 1360 12 CsCI CsCI NNP cord-009571-mygj2nd4 1360 13 gradient gradient NN cord-009571-mygj2nd4 1360 14 confirmed confirm VBD cord-009571-mygj2nd4 1360 15 this this DT cord-009571-mygj2nd4 1360 16 result result NN cord-009571-mygj2nd4 1360 17 . . . cord-009571-mygj2nd4 1361 1 In in IN cord-009571-mygj2nd4 1361 2 conclusion conclusion NN cord-009571-mygj2nd4 1361 3 , , , cord-009571-mygj2nd4 1361 4 the the DT cord-009571-mygj2nd4 1361 5 major major JJ cord-009571-mygj2nd4 1361 6 abnormality abnormality NN cord-009571-mygj2nd4 1361 7 detected detect VBD cord-009571-mygj2nd4 1361 8 early early RB cord-009571-mygj2nd4 1361 9 was be VBD cord-009571-mygj2nd4 1361 10 a a DT cord-009571-mygj2nd4 1361 11 disturbance disturbance NN cord-009571-mygj2nd4 1361 12 in in IN cord-009571-mygj2nd4 1361 13 PG PG NNP cord-009571-mygj2nd4 1361 14 aggregation aggregation NN cord-009571-mygj2nd4 1361 15 , , , cord-009571-mygj2nd4 1361 16 and and CC cord-009571-mygj2nd4 1361 17 later later RB cord-009571-mygj2nd4 1361 18 PGS PGS NNP cord-009571-mygj2nd4 1361 19 degradation degradation NN cord-009571-mygj2nd4 1361 20 . . . cord-009571-mygj2nd4 1362 1 We -PRON- PRP cord-009571-mygj2nd4 1362 2 recently recently RB cord-009571-mygj2nd4 1362 3 observed observe VBD cord-009571-mygj2nd4 1362 4 the the DT cord-009571-mygj2nd4 1362 5 development development NN cord-009571-mygj2nd4 1362 6 of of IN cord-009571-mygj2nd4 1362 7 glomerulonephritis glomerulonephritis NN cord-009571-mygj2nd4 1362 8 in in IN cord-009571-mygj2nd4 1362 9 3 3 CD cord-009571-mygj2nd4 1362 10 patients patient NNS cord-009571-mygj2nd4 1362 11 with with IN cord-009571-mygj2nd4 1362 12 sicca sicca NNP cord-009571-mygj2nd4 1362 13 syndrome syndrome NN cord-009571-mygj2nd4 1362 14 ( ( -LRB- cord-009571-mygj2nd4 1362 15 SS SS NNP cord-009571-mygj2nd4 1362 16 ) ) -RRB- cord-009571-mygj2nd4 1362 17 who who WP cord-009571-mygj2nd4 1362 18 did do VBD cord-009571-mygj2nd4 1362 19 not not RB cord-009571-mygj2nd4 1362 20 fulfill fulfill VB cord-009571-mygj2nd4 1362 21 the the DT cord-009571-mygj2nd4 1362 22 diagnostic diagnostic JJ cord-009571-mygj2nd4 1362 23 criteria criterion NNS cord-009571-mygj2nd4 1362 24 of of IN cord-009571-mygj2nd4 1362 25 systemic systemic JJ cord-009571-mygj2nd4 1362 26 lupus lupus NN cord-009571-mygj2nd4 1362 27 erythematosus erythematosus NN cord-009571-mygj2nd4 1362 28 . . . cord-009571-mygj2nd4 1363 1 These these DT cord-009571-mygj2nd4 1363 2 patients patient NNS cord-009571-mygj2nd4 1363 3 developed develop VBD cord-009571-mygj2nd4 1363 4 SS SS NNP cord-009571-mygj2nd4 1363 5 5 5 CD cord-009571-mygj2nd4 1363 6 to to IN cord-009571-mygj2nd4 1363 7 17 17 CD cord-009571-mygj2nd4 1363 8 years year NNS cord-009571-mygj2nd4 1363 9 prior prior RB cord-009571-mygj2nd4 1363 10 to to IN cord-009571-mygj2nd4 1363 11 the the DT cord-009571-mygj2nd4 1363 12 onset onset NN cord-009571-mygj2nd4 1363 13 of of IN cord-009571-mygj2nd4 1363 14 glomerulonephritis glomerulonephritis NN cord-009571-mygj2nd4 1363 15 . . . cord-009571-mygj2nd4 1364 1 Two two CD cord-009571-mygj2nd4 1364 2 were be VBD cord-009571-mygj2nd4 1364 3 diagnosed diagnose VBN cord-009571-mygj2nd4 1364 4 as as IN cord-009571-mygj2nd4 1364 5 having have VBG cord-009571-mygj2nd4 1364 6 membranoproliferative membranoproliferative JJ cord-009571-mygj2nd4 1364 7 glomerulonephritis glomerulonephritis NN cord-009571-mygj2nd4 1364 8 by by IN cord-009571-mygj2nd4 1364 9 light light NN cord-009571-mygj2nd4 1364 10 and and CC cord-009571-mygj2nd4 1364 11 electron electron NN cord-009571-mygj2nd4 1364 12 microscopy microscopy NN cord-009571-mygj2nd4 1364 13 , , , cord-009571-mygj2nd4 1364 14 and and CC cord-009571-mygj2nd4 1364 15 1 1 CD cord-009571-mygj2nd4 1364 16 was be VBD cord-009571-mygj2nd4 1364 17 found find VBN cord-009571-mygj2nd4 1364 18 to to TO cord-009571-mygj2nd4 1364 19 have have VB cord-009571-mygj2nd4 1364 20 membranous membranous JJ cord-009571-mygj2nd4 1364 21 glomerulonephritis glomerulonephritis NN cord-009571-mygj2nd4 1364 22 . . . cord-009571-mygj2nd4 1365 1 Although although IN cord-009571-mygj2nd4 1365 2 immunofluorescent immunofluorescent NNP cord-009571-mygj2nd4 1365 3 studies study NNS cord-009571-mygj2nd4 1365 4 were be VBD cord-009571-mygj2nd4 1365 5 not not RB cord-009571-mygj2nd4 1365 6 available available JJ cord-009571-mygj2nd4 1365 7 , , , cord-009571-mygj2nd4 1365 8 all all DT cord-009571-mygj2nd4 1365 9 clearly clearly RB cord-009571-mygj2nd4 1365 10 had have VBD cord-009571-mygj2nd4 1365 11 microscopic microscopic JJ cord-009571-mygj2nd4 1365 12 evidence evidence NN cord-009571-mygj2nd4 1365 13 of of IN cord-009571-mygj2nd4 1365 14 immune immune JJ cord-009571-mygj2nd4 1365 15 complex complex NN cord-009571-mygj2nd4 1365 16 ( ( -LRB- cord-009571-mygj2nd4 1365 17 IC IC NNP cord-009571-mygj2nd4 1365 18 ) ) -RRB- cord-009571-mygj2nd4 1365 19 deposition deposition NN cord-009571-mygj2nd4 1365 20 . . . cord-009571-mygj2nd4 1366 1 Moreover moreover RB cord-009571-mygj2nd4 1366 2 C'3 c'3 NN cord-009571-mygj2nd4 1366 3 levels level NNS cord-009571-mygj2nd4 1366 4 were be VBD cord-009571-mygj2nd4 1366 5 decreased decrease VBN cord-009571-mygj2nd4 1366 6 in in IN cord-009571-mygj2nd4 1366 7 all all DT cord-009571-mygj2nd4 1366 8 three three CD cord-009571-mygj2nd4 1366 9 a a DT cord-009571-mygj2nd4 1366 10 t t NN cord-009571-mygj2nd4 1366 11 the the DT cord-009571-mygj2nd4 1366 12 time time NN cord-009571-mygj2nd4 1366 13 of of IN cord-009571-mygj2nd4 1366 14 onset onset NN cord-009571-mygj2nd4 1366 15 of of IN cord-009571-mygj2nd4 1366 16 renal renal JJ cord-009571-mygj2nd4 1366 17 disease disease NN cord-009571-mygj2nd4 1366 18 , , , cord-009571-mygj2nd4 1366 19 and and CC cord-009571-mygj2nd4 1366 20 all all DT cord-009571-mygj2nd4 1366 21 had have VBD cord-009571-mygj2nd4 1366 22 high high JJ cord-009571-mygj2nd4 1366 23 levels level NNS cord-009571-mygj2nd4 1366 24 of of IN cord-009571-mygj2nd4 1366 25 circulating circulate VBG cord-009571-mygj2nd4 1366 26 IC IC NNP cord-009571-mygj2nd4 1366 27 as as IN cord-009571-mygj2nd4 1366 28 determined determine VBN cord-009571-mygj2nd4 1366 29 by by IN cord-009571-mygj2nd4 1366 30 the the DT cord-009571-mygj2nd4 1366 31 lZ6I lZ6I NNP cord-009571-mygj2nd4 1366 32 Clq Clq NNP cord-009571-mygj2nd4 1366 33 precipitation precipitation NN cord-009571-mygj2nd4 1366 34 test test NN cord-009571-mygj2nd4 1366 35 . . . cord-009571-mygj2nd4 1367 1 These these DT cord-009571-mygj2nd4 1367 2 findings finding NNS cord-009571-mygj2nd4 1367 3 raised raise VBD cord-009571-mygj2nd4 1367 4 the the DT cord-009571-mygj2nd4 1367 5 possibility possibility NN cord-009571-mygj2nd4 1367 6 that that IN cord-009571-mygj2nd4 1367 7 IC IC NNP cord-009571-mygj2nd4 1367 8 plays play VBZ cord-009571-mygj2nd4 1367 9 a a DT cord-009571-mygj2nd4 1367 10 role role NN cord-009571-mygj2nd4 1367 11 in in IN cord-009571-mygj2nd4 1367 12 the the DT cord-009571-mygj2nd4 1367 13 development development NN cord-009571-mygj2nd4 1367 14 of of IN cord-009571-mygj2nd4 1367 15 certain certain JJ cord-009571-mygj2nd4 1367 16 aspects aspect NNS cord-009571-mygj2nd4 1367 17 of of IN cord-009571-mygj2nd4 1367 18 tissue tissue NN cord-009571-mygj2nd4 1367 19 injury injury NN cord-009571-mygj2nd4 1367 20 in in IN cord-009571-mygj2nd4 1367 21 ss ss NNP cord-009571-mygj2nd4 1367 22 . . . cord-009571-mygj2nd4 1368 1 For for IN cord-009571-mygj2nd4 1368 2 these these DT cord-009571-mygj2nd4 1368 3 reasons reason NNS cord-009571-mygj2nd4 1368 4 55 55 CD cord-009571-mygj2nd4 1368 5 patients patient NNS cord-009571-mygj2nd4 1368 6 with with IN cord-009571-mygj2nd4 1368 7 SS SS NNP cord-009571-mygj2nd4 1368 8 were be VBD cord-009571-mygj2nd4 1368 9 studied study VBN cord-009571-mygj2nd4 1368 10 for for IN cord-009571-mygj2nd4 1368 11 the the DT cord-009571-mygj2nd4 1368 12 presence presence NN cord-009571-mygj2nd4 1368 13 of of IN cord-009571-mygj2nd4 1368 14 circulating circulate VBG cord-009571-mygj2nd4 1368 15 immune immune JJ cord-009571-mygj2nd4 1368 16 complexes complex NNS cord-009571-mygj2nd4 1368 17 with with IN cord-009571-mygj2nd4 1368 18 the the DT cord-009571-mygj2nd4 1368 19 laSI laSI NNP cord-009571-mygj2nd4 1368 20 Clq Clq NNP cord-009571-mygj2nd4 1368 21 precipitation precipitation NN cord-009571-mygj2nd4 1368 22 test test NN cord-009571-mygj2nd4 1368 23 . . . cord-009571-mygj2nd4 1369 1 Increased increase VBN cord-009571-mygj2nd4 1369 2 ' ' '' cord-009571-mygj2nd4 1369 3 ' ' '' cord-009571-mygj2nd4 1369 4 ' ' '' cord-009571-mygj2nd4 1369 5 1 1 CD cord-009571-mygj2nd4 1369 6 Clq Clq NNP cord-009571-mygj2nd4 1369 7 binding bind VBG cord-009571-mygj2nd4 1369 8 activity activity NN cord-009571-mygj2nd4 1369 9 ( ( -LRB- cord-009571-mygj2nd4 1369 10 ClqBA ClqBA NNP cord-009571-mygj2nd4 1369 11 ) ) -RRB- cord-009571-mygj2nd4 1369 12 ( ( -LRB- cord-009571-mygj2nd4 1369 13 10 10 CD cord-009571-mygj2nd4 1369 14 % % NN cord-009571-mygj2nd4 1369 15 ) ) -RRB- cord-009571-mygj2nd4 1369 16 was be VBD cord-009571-mygj2nd4 1369 17 found find VBN cord-009571-mygj2nd4 1369 18 in in IN cord-009571-mygj2nd4 1369 19 47 47 CD cord-009571-mygj2nd4 1369 20 ( ( -LRB- cord-009571-mygj2nd4 1369 21 86 86 CD cord-009571-mygj2nd4 1369 22 % % NN cord-009571-mygj2nd4 1369 23 ) ) -RRB- cord-009571-mygj2nd4 1369 24 patients patient NNS cord-009571-mygj2nd4 1369 25 ( ( -LRB- cord-009571-mygj2nd4 1369 26 mean mean VB cord-009571-mygj2nd4 1369 27 ClqBA ClqBA NNP cord-009571-mygj2nd4 1369 28 = = SYM cord-009571-mygj2nd4 1369 29 48 48 CD cord-009571-mygj2nd4 1369 30 % % NN cord-009571-mygj2nd4 1369 31 , , , cord-009571-mygj2nd4 1370 1 range range NNP cord-009571-mygj2nd4 1370 2 2 2 CD cord-009571-mygj2nd4 1370 3 - - SYM cord-009571-mygj2nd4 1370 4 98 98 CD cord-009571-mygj2nd4 1370 5 % % NN cord-009571-mygj2nd4 1370 6 ) ) -RRB- cord-009571-mygj2nd4 1370 7 . . . cord-009571-mygj2nd4 1371 1 Thirty thirty CD cord-009571-mygj2nd4 1371 2 - - HYPH cord-009571-mygj2nd4 1371 3 five five CD cord-009571-mygj2nd4 1371 4 patients patient NNS cord-009571-mygj2nd4 1371 5 ( ( -LRB- cord-009571-mygj2nd4 1371 6 64 64 CD cord-009571-mygj2nd4 1371 7 % % NN cord-009571-mygj2nd4 1371 8 ) ) -RRB- cord-009571-mygj2nd4 1371 9 had have VBD cord-009571-mygj2nd4 1371 10 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1371 11 factor factor NN cord-009571-mygj2nd4 1371 12 ( ( -LRB- cord-009571-mygj2nd4 1371 13 RF RF NNP cord-009571-mygj2nd4 1371 14 ) ) -RRB- cord-009571-mygj2nd4 1371 15 present present JJ cord-009571-mygj2nd4 1371 16 in in IN cord-009571-mygj2nd4 1371 17 their -PRON- PRP$ cord-009571-mygj2nd4 1371 18 serum serum NN cord-009571-mygj2nd4 1371 19 . . . cord-009571-mygj2nd4 1372 1 Analysis analysis NN cord-009571-mygj2nd4 1372 2 by by IN cord-009571-mygj2nd4 1372 3 Spearman Spearman NNP cord-009571-mygj2nd4 1372 4 rank rank NN cord-009571-mygj2nd4 1372 5 correlation correlation NN cord-009571-mygj2nd4 1372 6 revealed reveal VBD cord-009571-mygj2nd4 1372 7 a a DT cord-009571-mygj2nd4 1372 8 positive positive JJ cord-009571-mygj2nd4 1372 9 association association NN cord-009571-mygj2nd4 1372 10 between between IN cord-009571-mygj2nd4 1372 11 the the DT cord-009571-mygj2nd4 1372 12 ClqBA ClqBA NNP cord-009571-mygj2nd4 1372 13 and and CC cord-009571-mygj2nd4 1372 14 the the DT cord-009571-mygj2nd4 1372 15 titer titer NN cord-009571-mygj2nd4 1372 16 of of IN cord-009571-mygj2nd4 1372 17 R R NNP cord-009571-mygj2nd4 1372 18 F F NNP cord-009571-mygj2nd4 1372 19 as as IN cord-009571-mygj2nd4 1372 20 determined determine VBN cord-009571-mygj2nd4 1372 21 by by IN cord-009571-mygj2nd4 1372 22 the the DT cord-009571-mygj2nd4 1372 23 bentonite bentonite NN cord-009571-mygj2nd4 1372 24 flocculation flocculation NN cord-009571-mygj2nd4 1372 25 test test NN cord-009571-mygj2nd4 1372 26 ( ( -LRB- cord-009571-mygj2nd4 1372 27 BFT BFT NNP cord-009571-mygj2nd4 1372 28 ) ) -RRB- cord-009571-mygj2nd4 1372 29 , , , cord-009571-mygj2nd4 1372 30 ( ( -LRB- cord-009571-mygj2nd4 1372 31 rho rho NNP cord-009571-mygj2nd4 1372 32 = = SYM cord-009571-mygj2nd4 1372 33 0.551 0.551 CD cord-009571-mygj2nd4 1372 34 , , , cord-009571-mygj2nd4 1372 35 P p NN cord-009571-mygj2nd4 1372 36 < < XX cord-009571-mygj2nd4 1372 37 0.0005 0.0005 CD cord-009571-mygj2nd4 1372 38 ) ) -RRB- cord-009571-mygj2nd4 1372 39 . . . cord-009571-mygj2nd4 1373 1 It -PRON- PRP cord-009571-mygj2nd4 1373 2 was be VBD cord-009571-mygj2nd4 1373 3 found find VBN cord-009571-mygj2nd4 1373 4 that that IN cord-009571-mygj2nd4 1373 5 the the DT cord-009571-mygj2nd4 1373 6 highest high JJS cord-009571-mygj2nd4 1373 7 positive positive JJ cord-009571-mygj2nd4 1373 8 correlation correlation NN cord-009571-mygj2nd4 1373 9 between between IN cord-009571-mygj2nd4 1373 10 ClqBA ClqBA NNP cord-009571-mygj2nd4 1373 11 and and CC cord-009571-mygj2nd4 1373 12 BFT BFT NNP cord-009571-mygj2nd4 1373 13 titer titer NN cord-009571-mygj2nd4 1373 14 existed exist VBD cord-009571-mygj2nd4 1373 15 for for IN cord-009571-mygj2nd4 1373 16 those those DT cord-009571-mygj2nd4 1373 17 patients patient NNS cord-009571-mygj2nd4 1373 18 with with IN cord-009571-mygj2nd4 1373 19 SS SS NNP cord-009571-mygj2nd4 1373 20 alone alone RB cord-009571-mygj2nd4 1374 1 ( ( -LRB- cord-009571-mygj2nd4 1374 2 rho rho NNP cord-009571-mygj2nd4 1374 3 = = SYM cord-009571-mygj2nd4 1374 4 0.687 0.687 CD cord-009571-mygj2nd4 1374 5 , , , cord-009571-mygj2nd4 1374 6 P p NN cord-009571-mygj2nd4 1374 7 < < XX cord-009571-mygj2nd4 1374 8 O.OOS O.OOS NNP cord-009571-mygj2nd4 1374 9 ) ) -RRB- cord-009571-mygj2nd4 1374 10 , , , cord-009571-mygj2nd4 1374 11 and and CC cord-009571-mygj2nd4 1374 12 then then RB cord-009571-mygj2nd4 1374 13 decreased decrease VBD cord-009571-mygj2nd4 1374 14 for for IN cord-009571-mygj2nd4 1374 15 those those DT cord-009571-mygj2nd4 1374 16 patients patient NNS cord-009571-mygj2nd4 1374 17 with with IN cord-009571-mygj2nd4 1374 18 SS SS NNP cord-009571-mygj2nd4 1374 19 plus plus CC cord-009571-mygj2nd4 1374 20 extraglandular extraglandular NNP cord-009571-mygj2nd4 1374 21 disease disease NNP cord-009571-mygj2nd4 1374 22 ( ( -LRB- cord-009571-mygj2nd4 1374 23 rho rho NN cord-009571-mygj2nd4 1374 24 = = SYM cord-009571-mygj2nd4 1374 25 0.462 0.462 CD cord-009571-mygj2nd4 1374 26 , , , cord-009571-mygj2nd4 1374 27 P p NN cord-009571-mygj2nd4 1374 28 < < XX cord-009571-mygj2nd4 1374 29 0.05 0.05 CD cord-009571-mygj2nd4 1374 30 ) ) -RRB- cord-009571-mygj2nd4 1374 31 and and CC cord-009571-mygj2nd4 1374 32 even even RB cord-009571-mygj2nd4 1374 33 more more JJR cord-009571-mygj2nd4 1374 34 for for IN cord-009571-mygj2nd4 1374 35 patients patient NNS cord-009571-mygj2nd4 1374 36 with with IN cord-009571-mygj2nd4 1374 37 SS SS NNP cord-009571-mygj2nd4 1374 38 plus plus CC cord-009571-mygj2nd4 1374 39 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1374 40 arthritis arthritis NN cord-009571-mygj2nd4 1374 41 ( ( -LRB- cord-009571-mygj2nd4 1374 42 rho rho NN cord-009571-mygj2nd4 1374 43 = = NN cord-009571-mygj2nd4 1374 44 0.429 0.429 CD cord-009571-mygj2nd4 1374 45 , , , cord-009571-mygj2nd4 1375 1 0.05 0.05 CD cord-009571-mygj2nd4 1375 2 < < XX cord-009571-mygj2nd4 1375 3 P p NN cord-009571-mygj2nd4 1375 4 < < XX cord-009571-mygj2nd4 1375 5 0.10 0.10 CD cord-009571-mygj2nd4 1375 6 ) ) -RRB- cord-009571-mygj2nd4 1375 7 . . . cord-009571-mygj2nd4 1376 1 There there EX cord-009571-mygj2nd4 1376 2 was be VBD cord-009571-mygj2nd4 1376 3 no no DT cord-009571-mygj2nd4 1376 4 apparent apparent JJ cord-009571-mygj2nd4 1376 5 correlation correlation NN cord-009571-mygj2nd4 1376 6 between between IN cord-009571-mygj2nd4 1376 7 ClqBA ClqBA NNP cord-009571-mygj2nd4 1376 8 and and CC cord-009571-mygj2nd4 1376 9 BFT BFT NNP cord-009571-mygj2nd4 1376 10 titer titer NN cord-009571-mygj2nd4 1376 11 in in IN cord-009571-mygj2nd4 1376 12 patients patient NNS cord-009571-mygj2nd4 1376 13 with with IN cord-009571-mygj2nd4 1376 14 SS SS NNP cord-009571-mygj2nd4 1376 15 plus plus CC cord-009571-mygj2nd4 1376 16 another another DT cord-009571-mygj2nd4 1376 17 connective connective JJ cord-009571-mygj2nd4 1376 18 tissue tissue NN cord-009571-mygj2nd4 1376 19 disease disease NN cord-009571-mygj2nd4 1376 20 . . . cord-009571-mygj2nd4 1377 1 Pretreatment pretreatment NN cord-009571-mygj2nd4 1377 2 of of IN cord-009571-mygj2nd4 1377 3 10 10 CD cord-009571-mygj2nd4 1377 4 sera sera NNP cord-009571-mygj2nd4 1377 5 with with IN cord-009571-mygj2nd4 1377 6 0.01 0.01 CD cord-009571-mygj2nd4 1377 7 M M NNP cord-009571-mygj2nd4 1377 8 2mercaptoethanol 2mercaptoethanol NN cord-009571-mygj2nd4 1377 9 to to TO cord-009571-mygj2nd4 1377 10 dissociate dissociate VB cord-009571-mygj2nd4 1377 11 IgM IgM NNP cord-009571-mygj2nd4 1377 12 into into IN cord-009571-mygj2nd4 1377 13 monomers monomer NNS cord-009571-mygj2nd4 1377 14 resulted result VBD cord-009571-mygj2nd4 1377 15 in in IN cord-009571-mygj2nd4 1377 16 the the DT cord-009571-mygj2nd4 1377 17 eradication eradication NN cord-009571-mygj2nd4 1377 18 of of IN cord-009571-mygj2nd4 1377 19 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1377 20 factor factor NN cord-009571-mygj2nd4 1377 21 as as IN cord-009571-mygj2nd4 1377 22 measured measure VBN cord-009571-mygj2nd4 1377 23 by by IN cord-009571-mygj2nd4 1377 24 BFT BFT NNP cord-009571-mygj2nd4 1377 25 but but CC cord-009571-mygj2nd4 1377 26 caused cause VBD cord-009571-mygj2nd4 1377 27 only only RB cord-009571-mygj2nd4 1377 28 slight slight JJ cord-009571-mygj2nd4 1377 29 to to IN cord-009571-mygj2nd4 1377 30 moderate moderate JJ cord-009571-mygj2nd4 1377 31 reductions reduction NNS cord-009571-mygj2nd4 1377 32 in in IN cord-009571-mygj2nd4 1377 33 ClqBA ClqBA NNP cord-009571-mygj2nd4 1377 34 . . . cord-009571-mygj2nd4 1378 1 Thus thus RB cord-009571-mygj2nd4 1378 2 circulating circulate VBG cord-009571-mygj2nd4 1378 3 immune immune JJ cord-009571-mygj2nd4 1378 4 complexes complex NNS cord-009571-mygj2nd4 1378 5 exist exist VBP cord-009571-mygj2nd4 1378 6 in in IN cord-009571-mygj2nd4 1378 7 many many JJ cord-009571-mygj2nd4 1378 8 patients patient NNS cord-009571-mygj2nd4 1378 9 with with IN cord-009571-mygj2nd4 1378 10 SS SS NNP cord-009571-mygj2nd4 1378 11 , , , cord-009571-mygj2nd4 1378 12 are be VBP cord-009571-mygj2nd4 1378 13 distinct distinct JJ cord-009571-mygj2nd4 1378 14 from from IN cord-009571-mygj2nd4 1378 15 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1378 16 factor factor NN cord-009571-mygj2nd4 1378 17 , , , cord-009571-mygj2nd4 1378 18 and and CC cord-009571-mygj2nd4 1378 19 may may MD cord-009571-mygj2nd4 1378 20 contribute contribute VB cord-009571-mygj2nd4 1378 21 to to IN cord-009571-mygj2nd4 1378 22 certain certain JJ cord-009571-mygj2nd4 1378 23 aspects aspect NNS cord-009571-mygj2nd4 1378 24 of of IN cord-009571-mygj2nd4 1378 25 tissue tissue NN cord-009571-mygj2nd4 1378 26 damage damage NN cord-009571-mygj2nd4 1378 27 in in IN cord-009571-mygj2nd4 1378 28 this this DT cord-009571-mygj2nd4 1378 29 disease disease NN cord-009571-mygj2nd4 1378 30 . . . cord-009571-mygj2nd4 1379 1 We -PRON- PRP cord-009571-mygj2nd4 1379 2 have have VBP cord-009571-mygj2nd4 1379 3 recently recently RB cord-009571-mygj2nd4 1379 4 described describe VBN cord-009571-mygj2nd4 1379 5 a a DT cord-009571-mygj2nd4 1379 6 high high JJ cord-009571-mygj2nd4 1379 7 ( ( -LRB- cord-009571-mygj2nd4 1379 8 69 69 CD cord-009571-mygj2nd4 1379 9 % % NN cord-009571-mygj2nd4 1379 10 ) ) -RRB- cord-009571-mygj2nd4 1379 11 , , , cord-009571-mygj2nd4 1379 12 but but CC cord-009571-mygj2nd4 1379 13 not not RB cord-009571-mygj2nd4 1379 14 absolute absolute JJ cord-009571-mygj2nd4 1379 15 , , , cord-009571-mygj2nd4 1379 16 association association NN cord-009571-mygj2nd4 1379 17 of of IN cord-009571-mygj2nd4 1379 18 sicca sicca NNP cord-009571-mygj2nd4 1379 19 syndrome syndrome NN cord-009571-mygj2nd4 1379 20 ( ( -LRB- cord-009571-mygj2nd4 1379 21 SS SS NNP cord-009571-mygj2nd4 1379 22 ) ) -RRB- cord-009571-mygj2nd4 1379 23 with with IN cord-009571-mygj2nd4 1379 24 the the DT cord-009571-mygj2nd4 1379 25 HLA HLA NNP cord-009571-mygj2nd4 1379 26 - - HYPH cord-009571-mygj2nd4 1379 27 Dw3 dw3 NN cord-009571-mygj2nd4 1379 28 allelle allelle NN cord-009571-mygj2nd4 1379 29 , , , cord-009571-mygj2nd4 1379 30 which which WDT cord-009571-mygj2nd4 1379 31 is be VBZ cord-009571-mygj2nd4 1379 32 in in IN cord-009571-mygj2nd4 1379 33 linkage linkage NN cord-009571-mygj2nd4 1379 34 disequilibrium disequilibrium NN cord-009571-mygj2nd4 1379 35 with with IN cord-009571-mygj2nd4 1379 36 HLA HLA NNP cord-009571-mygj2nd4 1379 37 - - HYPH cord-009571-mygj2nd4 1379 38 B8 B8 NNP cord-009571-mygj2nd4 1379 39 ( ( -LRB- cord-009571-mygj2nd4 1379 40 NEJM NEJM NNP cord-009571-mygj2nd4 1379 41 296:895 296:895 CD cord-009571-mygj2nd4 1379 42 , , , cord-009571-mygj2nd4 1379 43 1977 1977 CD cord-009571-mygj2nd4 1379 44 ) ) -RRB- cord-009571-mygj2nd4 1379 45 . . . cord-009571-mygj2nd4 1380 1 In in IN cord-009571-mygj2nd4 1380 2 this this DT cord-009571-mygj2nd4 1380 3 study study NN cord-009571-mygj2nd4 1380 4 we -PRON- PRP cord-009571-mygj2nd4 1380 5 determined determine VBD cord-009571-mygj2nd4 1380 6 the the DT cord-009571-mygj2nd4 1380 7 Blymphocyte Blymphocyte NNP cord-009571-mygj2nd4 1380 8 antigens antigen NNS cord-009571-mygj2nd4 1380 9 of of IN cord-009571-mygj2nd4 1380 10 24 24 CD cord-009571-mygj2nd4 1380 11 patients patient NNS cord-009571-mygj2nd4 1380 12 ( ( -LRB- cord-009571-mygj2nd4 1380 13 21 21 CD cord-009571-mygj2nd4 1380 14 females female NNS cord-009571-mygj2nd4 1380 15 and and CC cord-009571-mygj2nd4 1380 16 3 3 CD cord-009571-mygj2nd4 1380 17 males male NNS cord-009571-mygj2nd4 1380 18 , , , cord-009571-mygj2nd4 1380 19 ages age NNS cord-009571-mygj2nd4 1380 20 26 26 CD cord-009571-mygj2nd4 1380 21 to to IN cord-009571-mygj2nd4 1380 22 73 73 CD cord-009571-mygj2nd4 1380 23 ) ) -RRB- cord-009571-mygj2nd4 1380 24 and and CC cord-009571-mygj2nd4 1380 25 184 184 CD cord-009571-mygj2nd4 1380 26 normal normal JJ cord-009571-mygj2nd4 1380 27 controls control NNS cord-009571-mygj2nd4 1380 28 . . . cord-009571-mygj2nd4 1381 1 In in IN cord-009571-mygj2nd4 1381 2 addition addition NN cord-009571-mygj2nd4 1381 3 to to IN cord-009571-mygj2nd4 1381 4 SS SS NNP cord-009571-mygj2nd4 1381 5 , , , cord-009571-mygj2nd4 1381 6 3 3 CD cord-009571-mygj2nd4 1381 7 of of IN cord-009571-mygj2nd4 1381 8 the the DT cord-009571-mygj2nd4 1381 9 patients patient NNS cord-009571-mygj2nd4 1381 10 have have VBP cord-009571-mygj2nd4 1381 11 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 1381 12 arthritis arthritis NN cord-009571-mygj2nd4 1381 13 and and CC cord-009571-mygj2nd4 1381 14 3 3 CD cord-009571-mygj2nd4 1381 15 have have VBP cord-009571-mygj2nd4 1381 16 systemic systemic JJ cord-009571-mygj2nd4 1381 17 lupus lupus NN cord-009571-mygj2nd4 1381 18 erythematosus erythematosus NN cord-009571-mygj2nd4 1381 19 . . . cord-009571-mygj2nd4 1382 1 Immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 1382 2 - - HYPH cord-009571-mygj2nd4 1382 3 bearing bear VBG cord-009571-mygj2nd4 1382 4 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 1382 5 were be VBD cord-009571-mygj2nd4 1382 6 separated separate VBN cord-009571-mygj2nd4 1382 7 from from IN cord-009571-mygj2nd4 1382 8 heparinized heparinized JJ cord-009571-mygj2nd4 1382 9 peripheral peripheral JJ cord-009571-mygj2nd4 1382 10 blood blood NN cord-009571-mygj2nd4 1382 11 on on IN cord-009571-mygj2nd4 1382 12 goat goat NN cord-009571-mygj2nd4 1382 13 anti anti JJ cord-009571-mygj2nd4 1382 14 - - JJ cord-009571-mygj2nd4 1382 15 human human JJ cord-009571-mygj2nd4 1382 16 IgG igg NN cord-009571-mygj2nd4 1382 17 ( ( -LRB- cord-009571-mygj2nd4 1382 18 Fab Fab NNP cord-009571-mygj2nd4 1382 19 ) ) -RRB- cord-009571-mygj2nd4 1382 20 coated coated JJ cord-009571-mygj2nd4 1382 21 plastic plastic NN cord-009571-mygj2nd4 1382 22 plates plate NNS cord-009571-mygj2nd4 1382 23 and and CC cord-009571-mygj2nd4 1382 24 tested test VBN cord-009571-mygj2nd4 1382 25 with with IN cord-009571-mygj2nd4 1382 26 60 60 CD cord-009571-mygj2nd4 1382 27 antisera antisera NN cord-009571-mygj2nd4 1382 28 in in IN cord-009571-mygj2nd4 1382 29 complement complement JJ cord-009571-mygj2nd4 1382 30 dependent dependent JJ cord-009571-mygj2nd4 1382 31 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 1382 32 tests test NNS cord-009571-mygj2nd4 1382 33 . . . cord-009571-mygj2nd4 1383 1 The the DT cord-009571-mygj2nd4 1383 2 antisera antisera NN cord-009571-mygj2nd4 1383 3 used use VBN cord-009571-mygj2nd4 1383 4 were be VBD cord-009571-mygj2nd4 1383 5 obtained obtain VBN cord-009571-mygj2nd4 1383 6 from from IN cord-009571-mygj2nd4 1383 7 multiparous multiparous JJ cord-009571-mygj2nd4 1383 8 women woman NNS cord-009571-mygj2nd4 1383 9 and and CC cord-009571-mygj2nd4 1383 10 absorbed absorb VBN cord-009571-mygj2nd4 1383 11 with with IN cord-009571-mygj2nd4 1383 12 pooled pool VBN cord-009571-mygj2nd4 1383 13 platelets platelet NNS cord-009571-mygj2nd4 1383 14 to to TO cord-009571-mygj2nd4 1383 15 remove remove VB cord-009571-mygj2nd4 1383 16 HLA HLA NNP cord-009571-mygj2nd4 1383 17 - - HYPH cord-009571-mygj2nd4 1383 18 A A NNP cord-009571-mygj2nd4 1383 19 , , , cord-009571-mygj2nd4 1383 20 -B -b ADD cord-009571-mygj2nd4 1383 21 , , , cord-009571-mygj2nd4 1383 22 and and CC cord-009571-mygj2nd4 1383 23 -C -C VBZ cord-009571-mygj2nd4 1383 24 antibodies antibody NNS cord-009571-mygj2nd4 1383 25 . . . cord-009571-mygj2nd4 1384 1 Two two CD cord-009571-mygj2nd4 1384 2 antisera antisera NN cord-009571-mygj2nd4 1384 3 , , , cord-009571-mygj2nd4 1384 4 172 172 CD cord-009571-mygj2nd4 1384 5 and and CC cord-009571-mygj2nd4 1384 6 AGS AGS NNP cord-009571-mygj2nd4 1384 7 , , , cord-009571-mygj2nd4 1384 8 reacted react VBD cord-009571-mygj2nd4 1384 9 with with IN cord-009571-mygj2nd4 1384 10 the the DT cord-009571-mygj2nd4 1384 11 B b NN cord-009571-mygj2nd4 1384 12 - - HYPH cord-009571-mygj2nd4 1384 13 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 1384 14 from from IN cord-009571-mygj2nd4 1384 15 all all PDT cord-009571-mygj2nd4 1384 16 the the DT cord-009571-mygj2nd4 1384 17 SS SS NNP cord-009571-mygj2nd4 1384 18 patients patient NNS cord-009571-mygj2nd4 1384 19 compared compare VBN cord-009571-mygj2nd4 1384 20 to to IN cord-009571-mygj2nd4 1384 21 37 37 CD cord-009571-mygj2nd4 1384 22 and and CC cord-009571-mygj2nd4 1384 23 24 24 CD cord-009571-mygj2nd4 1384 24 % % NN cord-009571-mygj2nd4 1384 25 of of IN cord-009571-mygj2nd4 1384 26 the the DT cord-009571-mygj2nd4 1384 27 normal normal JJ cord-009571-mygj2nd4 1384 28 controls control NNS cord-009571-mygj2nd4 1384 29 , , , cord-009571-mygj2nd4 1384 30 respectively respectively RB cord-009571-mygj2nd4 1384 31 . . . cord-009571-mygj2nd4 1385 1 Four four CD cord-009571-mygj2nd4 1385 2 additional additional JJ cord-009571-mygj2nd4 1385 3 antisera antisera NN cord-009571-mygj2nd4 1385 4 ( ( -LRB- cord-009571-mygj2nd4 1385 5 35,350,590 35,350,590 CD cord-009571-mygj2nd4 1385 6 , , , cord-009571-mygj2nd4 1385 7 and and CC cord-009571-mygj2nd4 1385 8 715 715 CD cord-009571-mygj2nd4 1385 9 ) ) -RRB- cord-009571-mygj2nd4 1385 10 reacted react VBD cord-009571-mygj2nd4 1385 11 more more RBR cord-009571-mygj2nd4 1385 12 frequently frequently RB cord-009571-mygj2nd4 1385 13 ( ( -LRB- cord-009571-mygj2nd4 1385 14 67,63,58 67,63,58 CD cord-009571-mygj2nd4 1385 15 , , , cord-009571-mygj2nd4 1385 16 and and CC cord-009571-mygj2nd4 1385 17 54 54 CD cord-009571-mygj2nd4 1385 18 % % NN cord-009571-mygj2nd4 1385 19 ) ) -RRB- cord-009571-mygj2nd4 1385 20 with with IN cord-009571-mygj2nd4 1385 21 the the DT cord-009571-mygj2nd4 1385 22 patients patient NNS cord-009571-mygj2nd4 1385 23 ' ' POS cord-009571-mygj2nd4 1385 24 B b NN cord-009571-mygj2nd4 1385 25 - - HYPH cord-009571-mygj2nd4 1385 26 cells cell NNS cord-009571-mygj2nd4 1385 27 than than IN cord-009571-mygj2nd4 1385 28 with with IN cord-009571-mygj2nd4 1385 29 those those DT cord-009571-mygj2nd4 1385 30 of of IN cord-009571-mygj2nd4 1385 31 controls control NNS cord-009571-mygj2nd4 1385 32 ( ( -LRB- cord-009571-mygj2nd4 1385 33 17 17 CD cord-009571-mygj2nd4 1385 34 , , , cord-009571-mygj2nd4 1385 35 21,24 21,24 CD cord-009571-mygj2nd4 1385 36 , , , cord-009571-mygj2nd4 1385 37 and and CC cord-009571-mygj2nd4 1385 38 14 14 CD cord-009571-mygj2nd4 1385 39 % % NN cord-009571-mygj2nd4 1385 40 ) ) -RRB- cord-009571-mygj2nd4 1385 41 . . . cord-009571-mygj2nd4 1386 1 The the DT cord-009571-mygj2nd4 1386 2 remainder remainder NN cord-009571-mygj2nd4 1386 3 of of IN cord-009571-mygj2nd4 1386 4 the the DT cord-009571-mygj2nd4 1386 5 antisera antisera NN cord-009571-mygj2nd4 1386 6 tested test VBN cord-009571-mygj2nd4 1386 7 had have VBD cord-009571-mygj2nd4 1386 8 the the DT cord-009571-mygj2nd4 1386 9 same same JJ cord-009571-mygj2nd4 1386 10 frequency frequency NN cord-009571-mygj2nd4 1386 11 of of IN cord-009571-mygj2nd4 1386 12 reactivity reactivity NN cord-009571-mygj2nd4 1386 13 in in IN cord-009571-mygj2nd4 1386 14 this this DT cord-009571-mygj2nd4 1386 15 disease disease NN cord-009571-mygj2nd4 1386 16 as as IN cord-009571-mygj2nd4 1386 17 in in IN cord-009571-mygj2nd4 1386 18 normals normal NNS cord-009571-mygj2nd4 1386 19 . . . cord-009571-mygj2nd4 1387 1 T T NNP cord-009571-mygj2nd4 1387 2 o o UH cord-009571-mygj2nd4 1387 3 determine determine NN cord-009571-mygj2nd4 1387 4 if if IN cord-009571-mygj2nd4 1387 5 these these DT cord-009571-mygj2nd4 1387 6 antisera antisera NN cord-009571-mygj2nd4 1387 7 recognized recognize VBD cord-009571-mygj2nd4 1387 8 the the DT cord-009571-mygj2nd4 1387 9 same same JJ cord-009571-mygj2nd4 1387 10 or or CC cord-009571-mygj2nd4 1387 11 different different JJ cord-009571-mygj2nd4 1387 12 antigens antigen NNS cord-009571-mygj2nd4 1387 13 , , , cord-009571-mygj2nd4 1387 14 their -PRON- PRP$ cord-009571-mygj2nd4 1387 15 reactions reaction NNS cord-009571-mygj2nd4 1387 16 with with IN cord-009571-mygj2nd4 1387 17 the the DT cord-009571-mygj2nd4 1387 18 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 1387 19 from from IN cord-009571-mygj2nd4 1387 20 the the DT cord-009571-mygj2nd4 1387 21 normal normal JJ cord-009571-mygj2nd4 1387 22 controls control NNS cord-009571-mygj2nd4 1387 23 were be VBD cord-009571-mygj2nd4 1387 24 compared compare VBN cord-009571-mygj2nd4 1387 25 by by IN cord-009571-mygj2nd4 1387 26 the the DT cord-009571-mygj2nd4 1387 27 x x NN cord-009571-mygj2nd4 1387 28 ' ' '' cord-009571-mygj2nd4 1387 29 test test NN cord-009571-mygj2nd4 1387 30 . . . cord-009571-mygj2nd4 1388 1 Antisera Antisera NNP cord-009571-mygj2nd4 1388 2 172 172 CD cord-009571-mygj2nd4 1388 3 correlated correlate VBD cord-009571-mygj2nd4 1388 4 with with IN cord-009571-mygj2nd4 1388 5 both both DT cord-009571-mygj2nd4 1388 6 35 35 CD cord-009571-mygj2nd4 1388 7 and and CC cord-009571-mygj2nd4 1388 8 350 350 CD cord-009571-mygj2nd4 1388 9 but but CC cord-009571-mygj2nd4 1388 10 not not RB cord-009571-mygj2nd4 1388 11 with with IN cord-009571-mygj2nd4 1388 12 AGS AGS NNP cord-009571-mygj2nd4 1388 13 or or CC cord-009571-mygj2nd4 1388 14 715 715 CD cord-009571-mygj2nd4 1388 15 . . . cord-009571-mygj2nd4 1389 1 Antisera Antisera NNP cord-009571-mygj2nd4 1389 2 AGS AGS NNP cord-009571-mygj2nd4 1389 3 correlated correlate VBD cord-009571-mygj2nd4 1389 4 only only RB cord-009571-mygj2nd4 1389 5 with with IN cord-009571-mygj2nd4 1389 6 7 7 CD cord-009571-mygj2nd4 1389 7 15 15 CD cord-009571-mygj2nd4 1389 8 . . . cord-009571-mygj2nd4 1390 1 Similar similar JJ cord-009571-mygj2nd4 1390 2 statistical statistical JJ cord-009571-mygj2nd4 1390 3 analysis analysis NN cord-009571-mygj2nd4 1390 4 was be VBD cord-009571-mygj2nd4 1390 5 done do VBN cord-009571-mygj2nd4 1390 6 for for IN cord-009571-mygj2nd4 1390 7 the the DT cord-009571-mygj2nd4 1390 8 patients patient NNS cord-009571-mygj2nd4 1390 9 . . . cord-009571-mygj2nd4 1391 1 The the DT cord-009571-mygj2nd4 1391 2 antisera antisera NN cord-009571-mygj2nd4 1391 3 172 172 CD cord-009571-mygj2nd4 1391 4 and and CC cord-009571-mygj2nd4 1391 5 AGS AGS NNP cord-009571-mygj2nd4 1391 6 were be VBD cord-009571-mygj2nd4 1391 7 excluded exclude VBN cord-009571-mygj2nd4 1391 8 because because IN cord-009571-mygj2nd4 1391 9 of of IN cord-009571-mygj2nd4 1391 10 their -PRON- PRP$ cord-009571-mygj2nd4 1391 11 100 100 CD cord-009571-mygj2nd4 1391 12 % % NN cord-009571-mygj2nd4 1391 13 prevalance prevalance NN cord-009571-mygj2nd4 1391 14 in in IN cord-009571-mygj2nd4 1391 15 SS SS NNP cord-009571-mygj2nd4 1391 16 . . . cord-009571-mygj2nd4 1392 1 In in IN cord-009571-mygj2nd4 1392 2 the the DT cord-009571-mygj2nd4 1392 3 SS SS NNP cord-009571-mygj2nd4 1392 4 patient patient NN cord-009571-mygj2nd4 1392 5 group group NN cord-009571-mygj2nd4 1392 6 antisera antisera NNP cord-009571-mygj2nd4 1392 7 35 35 CD cord-009571-mygj2nd4 1392 8 , , , cord-009571-mygj2nd4 1392 9 350 350 CD cord-009571-mygj2nd4 1392 10 , , , cord-009571-mygj2nd4 1392 11 and and CC cord-009571-mygj2nd4 1392 12 590 590 CD cord-009571-mygj2nd4 1392 13 were be VBD cord-009571-mygj2nd4 1392 14 associated associate VBN cord-009571-mygj2nd4 1392 15 with with IN cord-009571-mygj2nd4 1392 16 each each DT cord-009571-mygj2nd4 1392 17 other other JJ cord-009571-mygj2nd4 1392 18 but but CC cord-009571-mygj2nd4 1392 19 not not RB cord-009571-mygj2nd4 1392 20 with with IN cord-009571-mygj2nd4 1392 21 715 715 CD cord-009571-mygj2nd4 1392 22 . . . cord-009571-mygj2nd4 1393 1 This this DT cord-009571-mygj2nd4 1393 2 association association NN cord-009571-mygj2nd4 1393 3 can can MD cord-009571-mygj2nd4 1393 4 be be VB cord-009571-mygj2nd4 1393 5 due due JJ cord-009571-mygj2nd4 1393 6 t t NN cord-009571-mygj2nd4 1393 7 o o NN cord-009571-mygj2nd4 1394 1 either either CC cord-009571-mygj2nd4 1394 2 cross cross NN cord-009571-mygj2nd4 1394 3 - - NN cord-009571-mygj2nd4 1394 4 reactivity reactivity NN cord-009571-mygj2nd4 1394 5 or or CC cord-009571-mygj2nd4 1394 6 linkage linkage NN cord-009571-mygj2nd4 1394 7 disequilibrium disequilibrium NN cord-009571-mygj2nd4 1394 8 . . . cord-009571-mygj2nd4 1395 1 Family family NN cord-009571-mygj2nd4 1395 2 studies study NNS cord-009571-mygj2nd4 1395 3 are be VBP cord-009571-mygj2nd4 1395 4 in in IN cord-009571-mygj2nd4 1395 5 progress progress NN cord-009571-mygj2nd4 1395 6 to to TO cord-009571-mygj2nd4 1395 7 determine determine VB cord-009571-mygj2nd4 1395 8 whether whether IN cord-009571-mygj2nd4 1395 9 SS SS NNP cord-009571-mygj2nd4 1395 10 patients patient NNS cord-009571-mygj2nd4 1395 11 can can MD cord-009571-mygj2nd4 1395 12 be be VB cord-009571-mygj2nd4 1395 13 heterozygous heterozygous JJ cord-009571-mygj2nd4 1395 14 for for IN cord-009571-mygj2nd4 1395 15 172 172 CD cord-009571-mygj2nd4 1395 16 and and CC cord-009571-mygj2nd4 1395 17 AGS AGS NNP cord-009571-mygj2nd4 1395 18 and and CC cord-009571-mygj2nd4 1395 19 , , , cord-009571-mygj2nd4 1395 20 if if IN cord-009571-mygj2nd4 1395 21 so so RB cord-009571-mygj2nd4 1395 22 , , , cord-009571-mygj2nd4 1395 23 whether whether IN cord-009571-mygj2nd4 1395 24 they -PRON- PRP cord-009571-mygj2nd4 1395 25 can can MD cord-009571-mygj2nd4 1395 26 be be VB cord-009571-mygj2nd4 1395 27 present present JJ cord-009571-mygj2nd4 1395 28 in in IN cord-009571-mygj2nd4 1395 29 trans trans NNP cord-009571-mygj2nd4 1395 30 position position NN cord-009571-mygj2nd4 1395 31 . . . cord-009571-mygj2nd4 1396 1 Assuming assume VBG cord-009571-mygj2nd4 1396 2 that that IN cord-009571-mygj2nd4 1396 3 the the DT cord-009571-mygj2nd4 1396 4 B b NN cord-009571-mygj2nd4 1396 5 - - HYPH cord-009571-mygj2nd4 1396 6 lymphocyte lymphocyte NN cord-009571-mygj2nd4 1396 7 antigens antigen NNS cord-009571-mygj2nd4 1396 8 in in IN cord-009571-mygj2nd4 1396 9 humans human NNS cord-009571-mygj2nd4 1396 10 are be VBP cord-009571-mygj2nd4 1396 11 coded code VBN cord-009571-mygj2nd4 1396 12 by by IN cord-009571-mygj2nd4 1396 13 loci locus NNS cord-009571-mygj2nd4 1396 14 of of IN cord-009571-mygj2nd4 1396 15 an an DT cord-009571-mygj2nd4 1396 16 Ir Ir NNP cord-009571-mygj2nd4 1396 17 region region NN cord-009571-mygj2nd4 1396 18 , , , cord-009571-mygj2nd4 1396 19 our -PRON- PRP$ cord-009571-mygj2nd4 1396 20 results result NNS cord-009571-mygj2nd4 1396 21 suggest suggest VBP cord-009571-mygj2nd4 1396 22 that that IN cord-009571-mygj2nd4 1396 23 two two CD cord-009571-mygj2nd4 1396 24 immune immune JJ cord-009571-mygj2nd4 1396 25 response response NN cord-009571-mygj2nd4 1396 26 genes gene NNS cord-009571-mygj2nd4 1396 27 may may MD cord-009571-mygj2nd4 1396 28 be be VB cord-009571-mygj2nd4 1396 29 involved involve VBN cord-009571-mygj2nd4 1396 30 in in IN cord-009571-mygj2nd4 1396 31 the the DT cord-009571-mygj2nd4 1396 32 pathogenesis pathogenesis NN cord-009571-mygj2nd4 1396 33 of of IN cord-009571-mygj2nd4 1396 34 SS SS NNP cord-009571-mygj2nd4 1396 35 . . . cord-009571-mygj2nd4 1397 1 In in IN cord-009571-mygj2nd4 1397 2 addition addition NN cord-009571-mygj2nd4 1397 3 , , , cord-009571-mygj2nd4 1397 4 the the DT cord-009571-mygj2nd4 1397 5 absolute absolute JJ cord-009571-mygj2nd4 1397 6 association association NN cord-009571-mygj2nd4 1397 7 of of IN cord-009571-mygj2nd4 1397 8 172 172 CD cord-009571-mygj2nd4 1397 9 and and CC cord-009571-mygj2nd4 1397 10 AGS AGS NNP cord-009571-mygj2nd4 1397 11 antigens antigen NNS cord-009571-mygj2nd4 1397 12 with with IN cord-009571-mygj2nd4 1397 13 these these DT cord-009571-mygj2nd4 1397 14 patients patient NNS cord-009571-mygj2nd4 1397 15 should should MD cord-009571-mygj2nd4 1397 16 provide provide VB cord-009571-mygj2nd4 1397 17 a a DT cord-009571-mygj2nd4 1397 18 n n RB cord-009571-mygj2nd4 1397 19 additional additional JJ cord-009571-mygj2nd4 1397 20 aid aid NN cord-009571-mygj2nd4 1397 21 in in IN cord-009571-mygj2nd4 1397 22 diagnosis diagnosis NN cord-009571-mygj2nd4 1397 23 of of IN cord-009571-mygj2nd4 1397 24 SS SS NNP cord-009571-mygj2nd4 1397 25 . . . cord-009571-mygj2nd4 1398 1 Glucocorticoid Glucocorticoid NNP cord-009571-mygj2nd4 1398 2 administration administration NN cord-009571-mygj2nd4 1398 3 is be VBZ cord-009571-mygj2nd4 1398 4 associated associate VBN cord-009571-mygj2nd4 1398 5 with with IN cord-009571-mygj2nd4 1398 6 induction induction NN cord-009571-mygj2nd4 1398 7 of of IN cord-009571-mygj2nd4 1398 8 osteopenia osteopenia NN cord-009571-mygj2nd4 1398 9 in in IN cord-009571-mygj2nd4 1398 10 man man NN cord-009571-mygj2nd4 1398 11 and and CC cord-009571-mygj2nd4 1398 12 in in IN cord-009571-mygj2nd4 1398 13 some some DT cord-009571-mygj2nd4 1398 14 laboratory laboratory NN cord-009571-mygj2nd4 1398 15 animals animal NNS cord-009571-mygj2nd4 1398 16 . . . cord-009571-mygj2nd4 1399 1 There there EX cord-009571-mygj2nd4 1399 2 is be VBZ cord-009571-mygj2nd4 1399 3 debate debate NN cord-009571-mygj2nd4 1399 4 about about IN cord-009571-mygj2nd4 1399 5 dose dose NN cord-009571-mygj2nd4 1399 6 and and CC cord-009571-mygj2nd4 1399 7 duration duration NN cord-009571-mygj2nd4 1399 8 required require VBN cord-009571-mygj2nd4 1399 9 , , , cord-009571-mygj2nd4 1399 10 and and CC cord-009571-mygj2nd4 1399 11 whether whether IN cord-009571-mygj2nd4 1399 12 bone bone NN cord-009571-mygj2nd4 1399 13 loss loss NN cord-009571-mygj2nd4 1399 14 is be VBZ cord-009571-mygj2nd4 1399 15 primarily primarily RB cord-009571-mygj2nd4 1399 16 trabecular trabecular NNP cord-009571-mygj2nd4 1399 17 o o NN cord-009571-mygj2nd4 1399 18 r r NN cord-009571-mygj2nd4 1399 19 cortical cortical NN cord-009571-mygj2nd4 1399 20 . . . cord-009571-mygj2nd4 1400 1 Accordingly accordingly RB cord-009571-mygj2nd4 1400 2 , , , cord-009571-mygj2nd4 1400 3 18 18 CD cord-009571-mygj2nd4 1400 4 adult adult NN cord-009571-mygj2nd4 1400 5 female female JJ cord-009571-mygj2nd4 1400 6 rabbits rabbit NNS cord-009571-mygj2nd4 1400 7 were be VBD cord-009571-mygj2nd4 1400 8 divided divide VBN cord-009571-mygj2nd4 1400 9 into into IN cord-009571-mygj2nd4 1400 10 3 3 CD cord-009571-mygj2nd4 1400 11 groups group NNS cord-009571-mygj2nd4 1400 12 : : : cord-009571-mygj2nd4 1400 13 6 6 CD cord-009571-mygj2nd4 1400 14 received receive VBN cord-009571-mygj2nd4 1400 15 saline saline NN cord-009571-mygj2nd4 1400 16 , , , cord-009571-mygj2nd4 1400 17 6 6 CD cord-009571-mygj2nd4 1400 18 received receive VBD cord-009571-mygj2nd4 1400 19 1.5 1.5 CD cord-009571-mygj2nd4 1400 20 mg mg NNP cord-009571-mygj2nd4 1400 21 cortisol cortisol NN cord-009571-mygj2nd4 1400 22 / / SYM cord-009571-mygj2nd4 1400 23 kg kg NN cord-009571-mygj2nd4 1400 24 body body NN cord-009571-mygj2nd4 1400 25 weight weight NN cord-009571-mygj2nd4 1400 26 ( ( -LRB- cord-009571-mygj2nd4 1400 27 wt wt NN cord-009571-mygj2nd4 1400 28 ) ) -RRB- cord-009571-mygj2nd4 1400 29 , , , cord-009571-mygj2nd4 1400 30 and and CC cord-009571-mygj2nd4 1400 31 6 6 CD cord-009571-mygj2nd4 1400 32 received receive VBD cord-009571-mygj2nd4 1400 33 2.5 2.5 CD cord-009571-mygj2nd4 1400 34 mg mg NNP cord-009571-mygj2nd4 1400 35 cortisol cortisol NN cord-009571-mygj2nd4 1400 36 / / SYM cord-009571-mygj2nd4 1400 37 kg kg CC cord-009571-mygj2nd4 1400 38 wt wt NN cord-009571-mygj2nd4 1400 39 . . . cord-009571-mygj2nd4 1401 1 All all DT cord-009571-mygj2nd4 1401 2 received receive VBD cord-009571-mygj2nd4 1401 3 equal equal JJ cord-009571-mygj2nd4 1401 4 volumes volume NNS cord-009571-mygj2nd4 1401 5 subcutaneously subcutaneously RB cord-009571-mygj2nd4 1401 6 once once RB cord-009571-mygj2nd4 1401 7 daily daily RB cord-009571-mygj2nd4 1401 8 early early RB cord-009571-mygj2nd4 1401 9 in in IN cord-009571-mygj2nd4 1401 10 the the DT cord-009571-mygj2nd4 1401 11 morning morning NN cord-009571-mygj2nd4 1401 12 . . . cord-009571-mygj2nd4 1402 1 Xylenol Xylenol NNP cord-009571-mygj2nd4 1402 2 orange orange NN cord-009571-mygj2nd4 1402 3 ( ( -LRB- cord-009571-mygj2nd4 1402 4 50 50 CD cord-009571-mygj2nd4 1402 5 mg mg NNP cord-009571-mygj2nd4 1402 6 / / SYM cord-009571-mygj2nd4 1402 7 kg kg NNP cord-009571-mygj2nd4 1403 1 13 13 CD cord-009571-mygj2nd4 1403 2 days day NNS cord-009571-mygj2nd4 1403 3 before before IN cord-009571-mygj2nd4 1403 4 kill kill VBP cord-009571-mygj2nd4 1403 5 ) ) -RRB- cord-009571-mygj2nd4 1403 6 and and CC cord-009571-mygj2nd4 1403 7 tetracycline tetracycline NNP cord-009571-mygj2nd4 1403 8 ( ( -LRB- cord-009571-mygj2nd4 1403 9 1 1 CD cord-009571-mygj2nd4 1403 10 5 5 CD cord-009571-mygj2nd4 1403 11 mg/ mg/ NN cord-009571-mygj2nd4 1403 12 kg kg NN cord-009571-mygj2nd4 1403 13 2 2 CD cord-009571-mygj2nd4 1403 14 days day NNS cord-009571-mygj2nd4 1403 15 before before IN cord-009571-mygj2nd4 1403 16 kill kill NN cord-009571-mygj2nd4 1403 17 ) ) -RRB- cord-009571-mygj2nd4 1403 18 were be VBD cord-009571-mygj2nd4 1403 19 injected inject VBN cord-009571-mygj2nd4 1403 20 as as IN cord-009571-mygj2nd4 1403 21 bone bone NN cord-009571-mygj2nd4 1403 22 markers marker NNS cord-009571-mygj2nd4 1403 23 . . . cord-009571-mygj2nd4 1404 1 Rabbits rabbit NNS cord-009571-mygj2nd4 1404 2 were be VBD cord-009571-mygj2nd4 1404 3 given give VBN cord-009571-mygj2nd4 1404 4 food food NN cord-009571-mygj2nd4 1404 5 and and CC cord-009571-mygj2nd4 1404 6 water water NN cord-009571-mygj2nd4 1404 7 ad ad NN cord-009571-mygj2nd4 1404 8 libitum libitum NN cord-009571-mygj2nd4 1404 9 , , , cord-009571-mygj2nd4 1404 10 and and CC cord-009571-mygj2nd4 1404 11 weights weight NNS cord-009571-mygj2nd4 1404 12 were be VBD cord-009571-mygj2nd4 1404 13 measured measure VBN cord-009571-mygj2nd4 1404 14 every every DT cord-009571-mygj2nd4 1404 15 5 5 CD cord-009571-mygj2nd4 1404 16 - - SYM cord-009571-mygj2nd4 1404 17 6 6 CD cord-009571-mygj2nd4 1404 18 days day NNS cord-009571-mygj2nd4 1404 19 . . . cord-009571-mygj2nd4 1405 1 Bone bone NN cord-009571-mygj2nd4 1405 2 mineral mineral NN cord-009571-mygj2nd4 1405 3 content content NN cord-009571-mygj2nd4 1405 4 ( ( -LRB- cord-009571-mygj2nd4 1405 5 BMC BMC NNP cord-009571-mygj2nd4 1405 6 ) ) -RRB- cord-009571-mygj2nd4 1405 7 and and CC cord-009571-mygj2nd4 1405 8 width width NN cord-009571-mygj2nd4 1405 9 ( ( -LRB- cord-009571-mygj2nd4 1405 10 W w NN cord-009571-mygj2nd4 1405 11 ) ) -RRB- cord-009571-mygj2nd4 1405 12 were be VBD cord-009571-mygj2nd4 1405 13 measured measure VBN cord-009571-mygj2nd4 1405 14 by by IN cord-009571-mygj2nd4 1405 15 photon photon NN cord-009571-mygj2nd4 1405 16 absorptiometry absorptiometry NN cord-009571-mygj2nd4 1405 17 before before IN cord-009571-mygj2nd4 1405 18 treatment treatment NN cord-009571-mygj2nd4 1405 19 and and CC cord-009571-mygj2nd4 1405 20 every every DT cord-009571-mygj2nd4 1405 21 2 2 CD cord-009571-mygj2nd4 1405 22 weeks week NNS cord-009571-mygj2nd4 1405 23 . . . cord-009571-mygj2nd4 1406 1 Measurement measurement NN cord-009571-mygj2nd4 1406 2 site site NN cord-009571-mygj2nd4 1406 3 was be VBD cord-009571-mygj2nd4 1406 4 the the DT cord-009571-mygj2nd4 1406 5 humerus humerus NN cord-009571-mygj2nd4 1406 6 4 4 CD cord-009571-mygj2nd4 1406 7 cm cm NNS cord-009571-mygj2nd4 1406 8 proximal proximal JJ cord-009571-mygj2nd4 1406 9 to to IN cord-009571-mygj2nd4 1406 10 the the DT cord-009571-mygj2nd4 1406 11 bent bent JJ cord-009571-mygj2nd4 1406 12 elbow elbow NN cord-009571-mygj2nd4 1406 13 ( ( -LRB- cord-009571-mygj2nd4 1406 14 all all DT cord-009571-mygj2nd4 1406 15 cortical cortical JJ cord-009571-mygj2nd4 1406 16 bone bone NN cord-009571-mygj2nd4 1406 17 ) ) -RRB- cord-009571-mygj2nd4 1406 18 . . . cord-009571-mygj2nd4 1407 1 Results result NNS cord-009571-mygj2nd4 1407 2 are be VBP cord-009571-mygj2nd4 1407 3 shown show VBN cord-009571-mygj2nd4 1407 4 in in IN cord-009571-mygj2nd4 1407 5 the the DT cord-009571-mygj2nd4 1407 6 table table NN cord-009571-mygj2nd4 1407 7 . . . cord-009571-mygj2nd4 1408 1 Histopathology Histopathology NNP cord-009571-mygj2nd4 1408 2 . . . cord-009571-mygj2nd4 1409 1 The the DT cord-009571-mygj2nd4 1409 2 amount amount NN cord-009571-mygj2nd4 1409 3 of of IN cord-009571-mygj2nd4 1409 4 bone bone NN cord-009571-mygj2nd4 1409 5 was be VBD cord-009571-mygj2nd4 1409 6 reduced reduce VBN cord-009571-mygj2nd4 1409 7 in in IN cord-009571-mygj2nd4 1409 8 cortisol cortisol NN cord-009571-mygj2nd4 1409 9 - - HYPH cord-009571-mygj2nd4 1409 10 treated treat VBN cord-009571-mygj2nd4 1409 11 rabbits rabbit NNS cord-009571-mygj2nd4 1409 12 . . . cord-009571-mygj2nd4 1410 1 In in IN cord-009571-mygj2nd4 1410 2 the the DT cord-009571-mygj2nd4 1410 3 humerus humerus NN cord-009571-mygj2nd4 1410 4 this this DT cord-009571-mygj2nd4 1410 5 was be VBD cord-009571-mygj2nd4 1410 6 localized localize VBN cord-009571-mygj2nd4 1410 7 to to IN cord-009571-mygj2nd4 1410 8 the the DT cord-009571-mygj2nd4 1410 9 endosteal endosteal NN cord-009571-mygj2nd4 1410 10 surface surface NN cord-009571-mygj2nd4 1410 11 . . . cord-009571-mygj2nd4 1411 1 In in IN cord-009571-mygj2nd4 1411 2 the the DT cord-009571-mygj2nd4 1411 3 lumbar lumbar NN cord-009571-mygj2nd4 1411 4 vertebrae vertebrae NN cord-009571-mygj2nd4 1411 5 the the DT cord-009571-mygj2nd4 1411 6 endosteal endosteal NN cord-009571-mygj2nd4 1411 7 side side NN cord-009571-mygj2nd4 1411 8 of of IN cord-009571-mygj2nd4 1411 9 the the DT cord-009571-mygj2nd4 1411 10 ventral ventral JJ cord-009571-mygj2nd4 1411 11 cortex cortex NN cord-009571-mygj2nd4 1411 12 was be VBD cord-009571-mygj2nd4 1411 13 primarily primarily RB cord-009571-mygj2nd4 1411 14 affected affect VBN cord-009571-mygj2nd4 1411 15 with with IN cord-009571-mygj2nd4 1411 16 some some DT cord-009571-mygj2nd4 1411 17 thinning thinning NN cord-009571-mygj2nd4 1411 18 of of IN cord-009571-mygj2nd4 1411 19 trabeculae trabeculae NNP cord-009571-mygj2nd4 1411 20 . . . cord-009571-mygj2nd4 1412 1 Calculation calculation NN cord-009571-mygj2nd4 1412 2 of of IN cord-009571-mygj2nd4 1412 3 rates rate NNS cord-009571-mygj2nd4 1412 4 of of IN cord-009571-mygj2nd4 1412 5 formation formation NN cord-009571-mygj2nd4 1412 6 ( ( -LRB- cord-009571-mygj2nd4 1412 7 F F NNP cord-009571-mygj2nd4 1412 8 ) ) -RRB- cord-009571-mygj2nd4 1412 9 and and CC cord-009571-mygj2nd4 1412 10 resorption resorption NN cord-009571-mygj2nd4 1412 11 ( ( -LRB- cord-009571-mygj2nd4 1412 12 R r NN cord-009571-mygj2nd4 1412 13 ) ) -RRB- cord-009571-mygj2nd4 1412 14 showed show VBD cord-009571-mygj2nd4 1412 15 F F NNP cord-009571-mygj2nd4 1412 16 was be VBD cord-009571-mygj2nd4 1412 17 essentially essentially RB cord-009571-mygj2nd4 1412 18 nil nil NN cord-009571-mygj2nd4 1412 19 in in IN cord-009571-mygj2nd4 1412 20 the the DT cord-009571-mygj2nd4 1412 21 cortisol cortisol NN cord-009571-mygj2nd4 1412 22 groups group NNS cord-009571-mygj2nd4 1412 23 . . . cord-009571-mygj2nd4 1413 1 R r NN cord-009571-mygj2nd4 1413 2 was be VBD cord-009571-mygj2nd4 1413 3 identical identical JJ cord-009571-mygj2nd4 1413 4 in in IN cord-009571-mygj2nd4 1413 5 the the DT cord-009571-mygj2nd4 1413 6 saline saline NN cord-009571-mygj2nd4 1413 7 and and CC cord-009571-mygj2nd4 1413 8 low low JJ cord-009571-mygj2nd4 1413 9 - - HYPH cord-009571-mygj2nd4 1413 10 dose dose NN cord-009571-mygj2nd4 1413 11 cortisol cortisol NN cord-009571-mygj2nd4 1413 12 rabbits rabbit NNS cord-009571-mygj2nd4 1413 13 , , , cord-009571-mygj2nd4 1413 14 while while IN cord-009571-mygj2nd4 1413 15 R r NN cord-009571-mygj2nd4 1413 16 was be VBD cord-009571-mygj2nd4 1413 17 accelerated accelerate VBN cord-009571-mygj2nd4 1413 18 in in IN cord-009571-mygj2nd4 1413 19 the the DT cord-009571-mygj2nd4 1413 20 2.5 2.5 CD cord-009571-mygj2nd4 1413 21 mg mg NNP cord-009571-mygj2nd4 1413 22 / / SYM cord-009571-mygj2nd4 1413 23 kg kg NNS cord-009571-mygj2nd4 1413 24 treated treat VBN cord-009571-mygj2nd4 1413 25 rabbits rabbit NNS cord-009571-mygj2nd4 1413 26 . . . cord-009571-mygj2nd4 1414 1 Analysis Analysis NNP cord-009571-mygj2nd4 1414 2 of of IN cord-009571-mygj2nd4 1414 3 BMC BMC NNP cord-009571-mygj2nd4 1414 4 and and CC cord-009571-mygj2nd4 1414 5 cross cross NN cord-009571-mygj2nd4 1414 6 sections section NNS cord-009571-mygj2nd4 1414 7 from from IN cord-009571-mygj2nd4 1414 8 the the DT cord-009571-mygj2nd4 1414 9 same same JJ cord-009571-mygj2nd4 1414 10 site site NN cord-009571-mygj2nd4 1414 11 of of IN cord-009571-mygj2nd4 1414 12 the the DT cord-009571-mygj2nd4 1414 13 humerus humerus NNP cord-009571-mygj2nd4 1414 14 for for IN cord-009571-mygj2nd4 1414 15 bone bone NN cord-009571-mygj2nd4 1414 16 area area NN cord-009571-mygj2nd4 1414 17 showed show VBD cord-009571-mygj2nd4 1414 18 a a DT cord-009571-mygj2nd4 1414 19 good good JJ cord-009571-mygj2nd4 1414 20 correlation correlation NN cord-009571-mygj2nd4 1414 21 ( ( -LRB- cord-009571-mygj2nd4 1414 22 r r NN cord-009571-mygj2nd4 1414 23 = = NN cord-009571-mygj2nd4 1414 24 0.94 0.94 CD cord-009571-mygj2nd4 1414 25 ) ) -RRB- cord-009571-mygj2nd4 1414 26 . . . cord-009571-mygj2nd4 1415 1 Summary summary NN cord-009571-mygj2nd4 1415 2 . . . cord-009571-mygj2nd4 1416 1 Rabbits rabbit NNS cord-009571-mygj2nd4 1416 2 treated treat VBN cord-009571-mygj2nd4 1416 3 with with IN cord-009571-mygj2nd4 1416 4 cortisol cortisol NN cord-009571-mygj2nd4 1416 5 in in IN cord-009571-mygj2nd4 1416 6 the the DT cord-009571-mygj2nd4 1416 7 doses dose NNS cord-009571-mygj2nd4 1416 8 used use VBN cord-009571-mygj2nd4 1416 9 developed develop VBD cord-009571-mygj2nd4 1416 10 generalized generalized JJ cord-009571-mygj2nd4 1416 11 bone bone NN cord-009571-mygj2nd4 1416 12 loss loss NN cord-009571-mygj2nd4 1416 13 . . . cord-009571-mygj2nd4 1417 1 This this DT cord-009571-mygj2nd4 1417 2 loss loss NN cord-009571-mygj2nd4 1417 3 appears appear VBZ cord-009571-mygj2nd4 1417 4 to to TO cord-009571-mygj2nd4 1417 5 involve involve VB cord-009571-mygj2nd4 1417 6 more more JJR cord-009571-mygj2nd4 1417 7 cortical cortical JJ cord-009571-mygj2nd4 1417 8 than than IN cord-009571-mygj2nd4 1417 9 trabecular trabecular JJ cord-009571-mygj2nd4 1417 10 bone bone NN cord-009571-mygj2nd4 1417 11 . . . cord-009571-mygj2nd4 1418 1 Bone bone NN cord-009571-mygj2nd4 1418 2 marker marker NN cord-009571-mygj2nd4 1418 3 studies study NNS cord-009571-mygj2nd4 1418 4 show show VBP cord-009571-mygj2nd4 1418 5 that that IN cord-009571-mygj2nd4 1418 6 the the DT cord-009571-mygj2nd4 1418 7 main main JJ cord-009571-mygj2nd4 1418 8 effect effect NN cord-009571-mygj2nd4 1418 9 is be VBZ cord-009571-mygj2nd4 1418 10 interference interference NN cord-009571-mygj2nd4 1418 11 with with IN cord-009571-mygj2nd4 1418 12 F F NNP cord-009571-mygj2nd4 1418 13 , , , cord-009571-mygj2nd4 1418 14 and and CC cord-009571-mygj2nd4 1418 15 , , , cord-009571-mygj2nd4 1418 16 with with IN cord-009571-mygj2nd4 1418 17 the the DT cord-009571-mygj2nd4 1418 18 larger large JJR cord-009571-mygj2nd4 1418 19 dose dose NN cord-009571-mygj2nd4 1418 20 , , , cord-009571-mygj2nd4 1418 21 acceleration acceleration NN cord-009571-mygj2nd4 1418 22 of of IN cord-009571-mygj2nd4 1418 23 R. R. NNP cord-009571-mygj2nd4 1419 1 In in IN cord-009571-mygj2nd4 1419 2 vivo vivo NN cord-009571-mygj2nd4 1419 3 measurement measurement NN cord-009571-mygj2nd4 1419 4 of of IN cord-009571-mygj2nd4 1419 5 BMC BMC NNP cord-009571-mygj2nd4 1419 6 accurately accurately RB cord-009571-mygj2nd4 1419 7 reflects reflect VBZ cord-009571-mygj2nd4 1419 8 the the DT cord-009571-mygj2nd4 1419 9 progression progression NN cord-009571-mygj2nd4 1419 10 of of IN cord-009571-mygj2nd4 1419 11 the the DT cord-009571-mygj2nd4 1419 12 bone bone NN cord-009571-mygj2nd4 1419 13 loss loss NN cord-009571-mygj2nd4 1419 14 . . . cord-009571-mygj2nd4 1419 15 _SP cord-009571-mygj2nd4 1420 1 Intermediate intermediate JJ cord-009571-mygj2nd4 1420 2 complexes complex NNS cord-009571-mygj2nd4 1420 3 are be VBP cord-009571-mygj2nd4 1420 4 polymers polymer NNS cord-009571-mygj2nd4 1420 5 of of IN cord-009571-mygj2nd4 1420 6 IgG igg NN cord-009571-mygj2nd4 1420 7 - - HYPH cord-009571-mygj2nd4 1420 8 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1420 9 factor factor NN cord-009571-mygj2nd4 1420 10 which which WDT cord-009571-mygj2nd4 1420 11 sediment sediment NN cord-009571-mygj2nd4 1420 12 between between IN cord-009571-mygj2nd4 1420 13 the the DT cord-009571-mygj2nd4 1420 14 6.6s 6.6s CD cord-009571-mygj2nd4 1420 15 and and CC cord-009571-mygj2nd4 1420 16 19s 19s NNPS cord-009571-mygj2nd4 1420 17 components component NNS cord-009571-mygj2nd4 1420 18 of of IN cord-009571-mygj2nd4 1420 19 normal normal JJ cord-009571-mygj2nd4 1420 20 serum serum NN cord-009571-mygj2nd4 1420 21 . . . cord-009571-mygj2nd4 1421 1 They -PRON- PRP cord-009571-mygj2nd4 1421 2 are be VBP cord-009571-mygj2nd4 1421 3 best well RBS cord-009571-mygj2nd4 1421 4 identified identify VBN cord-009571-mygj2nd4 1421 5 by by IN cord-009571-mygj2nd4 1421 6 analytical analytical JJ cord-009571-mygj2nd4 1421 7 ultracentrifugation ultracentrifugation NN cord-009571-mygj2nd4 1421 8 . . . cord-009571-mygj2nd4 1422 1 Their -PRON- PRP$ cord-009571-mygj2nd4 1422 2 presence presence NN cord-009571-mygj2nd4 1422 3 in in IN cord-009571-mygj2nd4 1422 4 serum serum NN cord-009571-mygj2nd4 1422 5 can can MD cord-009571-mygj2nd4 1422 6 be be VB cord-009571-mygj2nd4 1422 7 inferred infer VBN cord-009571-mygj2nd4 1422 8 by by IN cord-009571-mygj2nd4 1422 9 a a DT cord-009571-mygj2nd4 1422 10 double double JJ cord-009571-mygj2nd4 1422 11 " " `` cord-009571-mygj2nd4 1422 12 gullwing gullwing NN cord-009571-mygj2nd4 1422 13 " " '' cord-009571-mygj2nd4 1422 14 precipitin precipitin JJ cord-009571-mygj2nd4 1422 15 line line NN cord-009571-mygj2nd4 1422 16 of of IN cord-009571-mygj2nd4 1422 17 the the DT cord-009571-mygj2nd4 1422 18 IgG IgG NNP cord-009571-mygj2nd4 1422 19 on on IN cord-009571-mygj2nd4 1422 20 immunoelectrophoresis immunoelectrophoresis NNP cord-009571-mygj2nd4 1422 21 due due IN cord-009571-mygj2nd4 1422 22 to to IN cord-009571-mygj2nd4 1422 23 accumulation accumulation NN cord-009571-mygj2nd4 1422 24 of of IN cord-009571-mygj2nd4 1422 25 the the DT cord-009571-mygj2nd4 1422 26 molecular molecular JJ cord-009571-mygj2nd4 1422 27 aggregates aggregate NNS cord-009571-mygj2nd4 1422 28 of of IN cord-009571-mygj2nd4 1422 29 IgG IgG NNP cord-009571-mygj2nd4 1422 30 around around IN cord-009571-mygj2nd4 1422 31 the the DT cord-009571-mygj2nd4 1422 32 well well NN cord-009571-mygj2nd4 1422 33 . . . cord-009571-mygj2nd4 1423 1 In in IN cord-009571-mygj2nd4 1423 2 this this DT cord-009571-mygj2nd4 1423 3 study study NN cord-009571-mygj2nd4 1423 4 we -PRON- PRP cord-009571-mygj2nd4 1423 5 have have VBP cord-009571-mygj2nd4 1423 6 shown show VBN cord-009571-mygj2nd4 1423 7 they -PRON- PRP cord-009571-mygj2nd4 1423 8 can can MD cord-009571-mygj2nd4 1423 9 also also RB cord-009571-mygj2nd4 1423 10 be be VB cord-009571-mygj2nd4 1423 11 detected detect VBN cord-009571-mygj2nd4 1423 12 by by IN cord-009571-mygj2nd4 1423 13 evaluation evaluation NN cord-009571-mygj2nd4 1423 14 of of IN cord-009571-mygj2nd4 1423 15 the the DT cord-009571-mygj2nd4 1423 16 difference difference NN cord-009571-mygj2nd4 1423 17 between between IN cord-009571-mygj2nd4 1423 18 the the DT cord-009571-mygj2nd4 1423 19 electrophoretically electrophoretically RB cord-009571-mygj2nd4 1423 20 determined determined JJ cord-009571-mygj2nd4 1423 21 y y NNP cord-009571-mygj2nd4 1423 22 - - HYPH cord-009571-mygj2nd4 1423 23 globulin globulin NN cord-009571-mygj2nd4 1423 24 concentration concentration NN cord-009571-mygj2nd4 1423 25 and and CC cord-009571-mygj2nd4 1423 26 the the DT cord-009571-mygj2nd4 1423 27 IgG igg NN cord-009571-mygj2nd4 1423 28 concentration concentration NN cord-009571-mygj2nd4 1423 29 determined determine VBN cord-009571-mygj2nd4 1423 30 by by IN cord-009571-mygj2nd4 1423 31 radial radial JJ cord-009571-mygj2nd4 1423 32 immunodiffusion immunodiffusion NN cord-009571-mygj2nd4 1423 33 ( ( -LRB- cord-009571-mygj2nd4 1423 34 RID rid VB cord-009571-mygj2nd4 1423 35 ) ) -RRB- cord-009571-mygj2nd4 1423 36 . . . cord-009571-mygj2nd4 1424 1 Molecular molecular JJ cord-009571-mygj2nd4 1424 2 aggregates aggregate NNS cord-009571-mygj2nd4 1424 3 of of IN cord-009571-mygj2nd4 1424 4 IgG IgG NNP cord-009571-mygj2nd4 1424 5 are be VBP cord-009571-mygj2nd4 1424 6 quantified quantify VBN cord-009571-mygj2nd4 1424 7 by by IN cord-009571-mygj2nd4 1424 8 serum serum NN cord-009571-mygj2nd4 1424 9 protein protein NN cord-009571-mygj2nd4 1424 10 electrophoresis electrophoresis NN cord-009571-mygj2nd4 1424 11 , , , cord-009571-mygj2nd4 1424 12 but but CC cord-009571-mygj2nd4 1424 13 they -PRON- PRP cord-009571-mygj2nd4 1424 14 are be VBP cord-009571-mygj2nd4 1424 15 underestimated underestimate VBN cord-009571-mygj2nd4 1424 16 by by IN cord-009571-mygj2nd4 1424 17 R r NN cord-009571-mygj2nd4 1424 18 I i NN cord-009571-mygj2nd4 1424 19 D d NN cord-009571-mygj2nd4 1424 20 because because IN cord-009571-mygj2nd4 1424 21 their -PRON- PRP$ cord-009571-mygj2nd4 1424 22 effective effective JJ cord-009571-mygj2nd4 1424 23 or or CC cord-009571-mygj2nd4 1424 24 molar molar JJ cord-009571-mygj2nd4 1424 25 concentration concentration NN cord-009571-mygj2nd4 1424 26 is be VBZ cord-009571-mygj2nd4 1424 27 low low JJ cord-009571-mygj2nd4 1424 28 relative relative JJ cord-009571-mygj2nd4 1424 29 to to IN cord-009571-mygj2nd4 1424 30 the the DT cord-009571-mygj2nd4 1424 31 monomeric monomeric JJ cord-009571-mygj2nd4 1424 32 IgG IgG NNP cord-009571-mygj2nd4 1424 33 standard standard NN cord-009571-mygj2nd4 1424 34 . . . cord-009571-mygj2nd4 1425 1 Therefore therefore RB cord-009571-mygj2nd4 1425 2 , , , cord-009571-mygj2nd4 1425 3 when when WRB cord-009571-mygj2nd4 1425 4 molecular molecular JJ cord-009571-mygj2nd4 1425 5 aggregates aggregate NNS cord-009571-mygj2nd4 1425 6 of of IN cord-009571-mygj2nd4 1425 7 IgG IgG NNP cord-009571-mygj2nd4 1425 8 are be VBP cord-009571-mygj2nd4 1425 9 present present JJ cord-009571-mygj2nd4 1425 10 , , , cord-009571-mygj2nd4 1425 11 the the DT cord-009571-mygj2nd4 1425 12 difference difference NN cord-009571-mygj2nd4 1425 13 between between IN cord-009571-mygj2nd4 1425 14 the the DT cord-009571-mygj2nd4 1425 15 electrophoretically electrophoretically RB cord-009571-mygj2nd4 1425 16 determined determined JJ cord-009571-mygj2nd4 1425 17 y y NNP cord-009571-mygj2nd4 1425 18 - - HYPH cord-009571-mygj2nd4 1425 19 globulin globulin NNP cord-009571-mygj2nd4 1425 20 and and CC cord-009571-mygj2nd4 1425 21 the the DT cord-009571-mygj2nd4 1425 22 IgG igg NN cord-009571-mygj2nd4 1425 23 measured measure VBN cord-009571-mygj2nd4 1425 24 by by IN cord-009571-mygj2nd4 1425 25 R r NN cord-009571-mygj2nd4 1425 26 I i NN cord-009571-mygj2nd4 1425 27 D d NN cord-009571-mygj2nd4 1425 28 is be VBZ cord-009571-mygj2nd4 1425 29 abnormally abnormally RB cord-009571-mygj2nd4 1425 30 high high JJ cord-009571-mygj2nd4 1425 31 . . . cord-009571-mygj2nd4 1426 1 Sixty sixty CD cord-009571-mygj2nd4 1426 2 - - HYPH cord-009571-mygj2nd4 1426 3 one one CD cord-009571-mygj2nd4 1426 4 consecutive consecutive JJ cord-009571-mygj2nd4 1426 5 blood blood NN cord-009571-mygj2nd4 1426 6 donor donor NN cord-009571-mygj2nd4 1426 7 sera sera NNP cord-009571-mygj2nd4 1426 8 and and CC cord-009571-mygj2nd4 1426 9 46 46 CD cord-009571-mygj2nd4 1426 10 hypergammaglobulinemic hypergammaglobulinemic NNP cord-009571-mygj2nd4 1426 11 sera sera NNP cord-009571-mygj2nd4 1426 12 from from IN cord-009571-mygj2nd4 1426 13 patients patient NNS cord-009571-mygj2nd4 1426 14 with with IN cord-009571-mygj2nd4 1426 15 diseases disease NNS cord-009571-mygj2nd4 1426 16 known know VBN cord-009571-mygj2nd4 1426 17 not not RB cord-009571-mygj2nd4 1426 18 to to TO cord-009571-mygj2nd4 1426 19 be be VB cord-009571-mygj2nd4 1426 20 associated associate VBN cord-009571-mygj2nd4 1426 21 with with IN cord-009571-mygj2nd4 1426 22 the the DT cord-009571-mygj2nd4 1426 23 presence presence NN cord-009571-mygj2nd4 1426 24 of of IN cord-009571-mygj2nd4 1426 25 intermediate intermediate JJ cord-009571-mygj2nd4 1426 26 complexes complex NNS cord-009571-mygj2nd4 1427 1 o o UH cord-009571-mygj2nd4 1427 2 r r NN cord-009571-mygj2nd4 1427 3 in in IN cord-009571-mygj2nd4 1427 4 which which WDT cord-009571-mygj2nd4 1427 5 the the DT cord-009571-mygj2nd4 1427 6 presence presence NN cord-009571-mygj2nd4 1427 7 of of IN cord-009571-mygj2nd4 1427 8 intermediate intermediate JJ cord-009571-mygj2nd4 1427 9 complexes complex NNS cord-009571-mygj2nd4 1427 10 was be VBD cord-009571-mygj2nd4 1427 11 excluded exclude VBN cord-009571-mygj2nd4 1427 12 by by IN cord-009571-mygj2nd4 1427 13 analytical analytical JJ cord-009571-mygj2nd4 1427 14 ultracentrifugation ultracentrifugation NN cord-009571-mygj2nd4 1427 15 made make VBD cord-009571-mygj2nd4 1427 16 up up RP cord-009571-mygj2nd4 1427 17 the the DT cord-009571-mygj2nd4 1427 18 reference reference NN cord-009571-mygj2nd4 1427 19 population population NN cord-009571-mygj2nd4 1427 20 . . . cord-009571-mygj2nd4 1428 1 Eleven Eleven NNP cord-009571-mygj2nd4 1428 2 sera sera NNP cord-009571-mygj2nd4 1428 3 with with IN cord-009571-mygj2nd4 1428 4 known know VBN cord-009571-mygj2nd4 1428 5 intermediate intermediate JJ cord-009571-mygj2nd4 1428 6 complexes complex NNS cord-009571-mygj2nd4 1428 7 were be VBD cord-009571-mygj2nd4 1428 8 examined examine VBN cord-009571-mygj2nd4 1428 9 . . . cord-009571-mygj2nd4 1429 1 The the DT cord-009571-mygj2nd4 1429 2 mean mean NN cord-009571-mygj2nd4 1429 3 and and CC cord-009571-mygj2nd4 1429 4 95 95 CD cord-009571-mygj2nd4 1429 5 % % NN cord-009571-mygj2nd4 1429 6 tolerance tolerance NN cord-009571-mygj2nd4 1429 7 intervals interval NNS cord-009571-mygj2nd4 1429 8 ( ( -LRB- cord-009571-mygj2nd4 1429 9 covering cover VBG cord-009571-mygj2nd4 1429 10 99 99 CD cord-009571-mygj2nd4 1429 11 % % NN cord-009571-mygj2nd4 1429 12 of of IN cord-009571-mygj2nd4 1429 13 the the DT cord-009571-mygj2nd4 1429 14 population population NN cord-009571-mygj2nd4 1429 15 with with IN cord-009571-mygj2nd4 1429 16 95 95 CD cord-009571-mygj2nd4 1429 17 % % NN cord-009571-mygj2nd4 1429 18 confidence confidence NN cord-009571-mygj2nd4 1429 19 ) ) -RRB- cord-009571-mygj2nd4 1429 20 of of IN cord-009571-mygj2nd4 1429 21 the the DT cord-009571-mygj2nd4 1429 22 reference reference NN cord-009571-mygj2nd4 1429 23 population population NN cord-009571-mygj2nd4 1429 24 for for IN cord-009571-mygj2nd4 1429 25 the the DT cord-009571-mygj2nd4 1429 26 difference difference NN cord-009571-mygj2nd4 1429 27 between between IN cord-009571-mygj2nd4 1429 28 the the DT cord-009571-mygj2nd4 1429 29 electrophoretically electrophoretically RB cord-009571-mygj2nd4 1429 30 determined determined JJ cord-009571-mygj2nd4 1429 31 y y NNP cord-009571-mygj2nd4 1429 32 - - HYPH cord-009571-mygj2nd4 1429 33 globulin globulin NN cord-009571-mygj2nd4 1429 34 concentration concentration NN cord-009571-mygj2nd4 1429 35 and and CC cord-009571-mygj2nd4 1429 36 the the DT cord-009571-mygj2nd4 1429 37 IgG igg NN cord-009571-mygj2nd4 1429 38 as as IN cord-009571-mygj2nd4 1429 39 measured measure VBN cord-009571-mygj2nd4 1429 40 by by IN cord-009571-mygj2nd4 1429 41 R r NN cord-009571-mygj2nd4 1429 42 I i NN cord-009571-mygj2nd4 1429 43 D d NN cord-009571-mygj2nd4 1429 44 was be VBD cord-009571-mygj2nd4 1429 45 0.31 0.31 CD cord-009571-mygj2nd4 1429 46 f f NN cord-009571-mygj2nd4 1429 47 0.73 0.73 CD cord-009571-mygj2nd4 1429 48 g g NNP cord-009571-mygj2nd4 1429 49 / / SYM cord-009571-mygj2nd4 1429 50 dl dl NN cord-009571-mygj2nd4 1429 51 . . . cord-009571-mygj2nd4 1430 1 Eight eight CD cord-009571-mygj2nd4 1430 2 of of IN cord-009571-mygj2nd4 1430 3 I -PRON- PRP cord-009571-mygj2nd4 1430 4 1 1 CD cord-009571-mygj2nd4 1430 5 patients patient NNS cord-009571-mygj2nd4 1430 6 ' ' POS cord-009571-mygj2nd4 1430 7 sera sera NNP cord-009571-mygj2nd4 1430 8 with with IN cord-009571-mygj2nd4 1430 9 known know VBN cord-009571-mygj2nd4 1430 10 intermediate intermediate JJ cord-009571-mygj2nd4 1430 11 complexes complex NNS cord-009571-mygj2nd4 1430 12 fell fall VBD cord-009571-mygj2nd4 1430 13 outside outside IN cord-009571-mygj2nd4 1430 14 the the DT cord-009571-mygj2nd4 1430 15 upper upper JJ cord-009571-mygj2nd4 1430 16 limit limit NN cord-009571-mygj2nd4 1430 17 . . . cord-009571-mygj2nd4 1431 1 All all DT cord-009571-mygj2nd4 1431 2 3 3 CD cord-009571-mygj2nd4 1431 3 sera sera NNP cord-009571-mygj2nd4 1431 4 which which WDT cord-009571-mygj2nd4 1431 5 fell fall VBD cord-009571-mygj2nd4 1431 6 within within IN cord-009571-mygj2nd4 1431 7 the the DT cord-009571-mygj2nd4 1431 8 95 95 CD cord-009571-mygj2nd4 1431 9 % % NN cord-009571-mygj2nd4 1431 10 intervals interval NNS cord-009571-mygj2nd4 1431 11 had have VBD cord-009571-mygj2nd4 1431 12 concentrations concentration NNS cord-009571-mygj2nd4 1431 13 of of IN cord-009571-mygj2nd4 1431 14 intermediate intermediate JJ cord-009571-mygj2nd4 1431 15 complexes complex NNS cord-009571-mygj2nd4 1431 16 less less JJR cord-009571-mygj2nd4 1431 17 than than IN cord-009571-mygj2nd4 1431 18 1.8 1.8 CD cord-009571-mygj2nd4 1431 19 g/ g/ NNP cord-009571-mygj2nd4 1431 20 dl dl NN cord-009571-mygj2nd4 1431 21 . . . cord-009571-mygj2nd4 1432 1 In in IN cord-009571-mygj2nd4 1432 2 addition addition NN cord-009571-mygj2nd4 1432 3 , , , cord-009571-mygj2nd4 1432 4 the the DT cord-009571-mygj2nd4 1432 5 degree degree NN cord-009571-mygj2nd4 1432 6 of of IN cord-009571-mygj2nd4 1432 7 deviation deviation NN cord-009571-mygj2nd4 1432 8 from from IN cord-009571-mygj2nd4 1432 9 the the DT cord-009571-mygj2nd4 1432 10 reference reference NN cord-009571-mygj2nd4 1432 11 mean mean NN cord-009571-mygj2nd4 1432 12 showed show VBD cord-009571-mygj2nd4 1432 13 a a DT cord-009571-mygj2nd4 1432 14 direct direct JJ cord-009571-mygj2nd4 1432 15 linear linear JJ cord-009571-mygj2nd4 1432 16 correlation correlation NN cord-009571-mygj2nd4 1432 17 with with IN cord-009571-mygj2nd4 1432 18 the the DT cord-009571-mygj2nd4 1432 19 level level NN cord-009571-mygj2nd4 1432 20 of of IN cord-009571-mygj2nd4 1432 21 intermediate intermediate JJ cord-009571-mygj2nd4 1432 22 complexes complex NNS cord-009571-mygj2nd4 1432 23 present present JJ cord-009571-mygj2nd4 1432 24 . . . cord-009571-mygj2nd4 1433 1 If if IN cord-009571-mygj2nd4 1433 2 the the DT cord-009571-mygj2nd4 1433 3 electrophoretically electrophoretically RB cord-009571-mygj2nd4 1433 4 determined determine VBD cord-009571-mygj2nd4 1433 5 y y NNP cord-009571-mygj2nd4 1433 6 - - HYPH cord-009571-mygj2nd4 1433 7 globulin globulin NN cord-009571-mygj2nd4 1433 8 concentration concentration NN cord-009571-mygj2nd4 1433 9 minus minus IN cord-009571-mygj2nd4 1433 10 the the DT cord-009571-mygj2nd4 1433 11 IgG IgG NNP cord-009571-mygj2nd4 1433 12 concentra concentra NNP cord-009571-mygj2nd4 1433 13 - - HYPH cord-009571-mygj2nd4 1433 14 tion tion NNP cord-009571-mygj2nd4 1433 15 by by IN cord-009571-mygj2nd4 1433 16 R r NN cord-009571-mygj2nd4 1433 17 I i NN cord-009571-mygj2nd4 1433 18 D d NN cord-009571-mygj2nd4 1433 19 is be VBZ cord-009571-mygj2nd4 1433 20 greater great JJR cord-009571-mygj2nd4 1433 21 than than IN cord-009571-mygj2nd4 1433 22 1 1 CD cord-009571-mygj2nd4 1433 23 .O .o CD cord-009571-mygj2nd4 1433 24 g g NNP cord-009571-mygj2nd4 1433 25 / / SYM cord-009571-mygj2nd4 1433 26 dl dl NN cord-009571-mygj2nd4 1433 27 , , , cord-009571-mygj2nd4 1433 28 intermediate intermediate JJ cord-009571-mygj2nd4 1433 29 complexes complex NNS cord-009571-mygj2nd4 1433 30 should should MD cord-009571-mygj2nd4 1433 31 be be VB cord-009571-mygj2nd4 1433 32 presumed presume VBN cord-009571-mygj2nd4 1433 33 to to TO cord-009571-mygj2nd4 1433 34 be be VB cord-009571-mygj2nd4 1433 35 present present JJ cord-009571-mygj2nd4 1433 36 in in IN cord-009571-mygj2nd4 1433 37 concentrations concentration NNS cord-009571-mygj2nd4 1433 38 greater great JJR cord-009571-mygj2nd4 1433 39 than than IN cord-009571-mygj2nd4 1433 40 1.8 1.8 CD cord-009571-mygj2nd4 1433 41 g g NN cord-009571-mygj2nd4 1433 42 / / SYM cord-009571-mygj2nd4 1433 43 dl dl NN cord-009571-mygj2nd4 1433 44 . . . cord-009571-mygj2nd4 1434 1 Synthesis synthesis NN cord-009571-mygj2nd4 1434 2 of of IN cord-009571-mygj2nd4 1434 3 antibodies antibody NNS cord-009571-mygj2nd4 1434 4 to to IN cord-009571-mygj2nd4 1434 5 DNA DNA NNP cord-009571-mygj2nd4 1434 6 ( ( -LRB- cord-009571-mygj2nd4 1434 7 anti anti JJ cord-009571-mygj2nd4 1434 8 - - JJ cord-009571-mygj2nd4 1434 9 DNA dna JJ cord-009571-mygj2nd4 1434 10 ) ) -RRB- cord-009571-mygj2nd4 1434 11 in in IN cord-009571-mygj2nd4 1434 12 systemic systemic JJ cord-009571-mygj2nd4 1434 13 lupus lupus NN cord-009571-mygj2nd4 1434 14 erythematosus erythematosus NN cord-009571-mygj2nd4 1434 15 ( ( -LRB- cord-009571-mygj2nd4 1434 16 SLE SLE NNP cord-009571-mygj2nd4 1434 17 ) ) -RRB- cord-009571-mygj2nd4 1434 18 is be VBZ cord-009571-mygj2nd4 1434 19 postulated postulate VBN cord-009571-mygj2nd4 1434 20 t t NNP cord-009571-mygj2nd4 1434 21 o o NN cord-009571-mygj2nd4 1434 22 result result NN cord-009571-mygj2nd4 1434 23 from from IN cord-009571-mygj2nd4 1434 24 a a DT cord-009571-mygj2nd4 1434 25 lack lack NN cord-009571-mygj2nd4 1434 26 of of IN cord-009571-mygj2nd4 1434 27 control control NN cord-009571-mygj2nd4 1434 28 mechanisms mechanism NNS cord-009571-mygj2nd4 1434 29 which which WDT cord-009571-mygj2nd4 1434 30 normally normally RB cord-009571-mygj2nd4 1434 31 suppress suppress VBP cord-009571-mygj2nd4 1434 32 autoantibody autoantibody NN cord-009571-mygj2nd4 1434 33 production production NN cord-009571-mygj2nd4 1434 34 . . . cord-009571-mygj2nd4 1435 1 We -PRON- PRP cord-009571-mygj2nd4 1435 2 investigated investigate VBD cord-009571-mygj2nd4 1435 3 these these DT cord-009571-mygj2nd4 1435 4 mechanisms mechanism NNS cord-009571-mygj2nd4 1435 5 by by IN cord-009571-mygj2nd4 1435 6 measuring measure VBG cord-009571-mygj2nd4 1435 7 anti anti JJ cord-009571-mygj2nd4 1435 8 - - JJ cord-009571-mygj2nd4 1435 9 DNA dna JJ cord-009571-mygj2nd4 1435 10 synthesis synthesis NN cord-009571-mygj2nd4 1435 11 by by IN cord-009571-mygj2nd4 1435 12 normal normal JJ cord-009571-mygj2nd4 1435 13 and and CC cord-009571-mygj2nd4 1435 14 SLE SLE NNP cord-009571-mygj2nd4 1435 15 peripheral peripheral JJ cord-009571-mygj2nd4 1435 16 blood blood NN cord-009571-mygj2nd4 1435 17 lymphocyte lymphocyte NN cord-009571-mygj2nd4 1435 18 ( ( -LRB- cord-009571-mygj2nd4 1435 19 PBL PBL NNP cord-009571-mygj2nd4 1435 20 ) ) -RRB- cord-009571-mygj2nd4 1435 21 populations population NNS cord-009571-mygj2nd4 1435 22 stimulated stimulate VBN cord-009571-mygj2nd4 1435 23 with with IN cord-009571-mygj2nd4 1435 24 pokeweed pokeweed JJ cord-009571-mygj2nd4 1435 25 mitogen mitogen NN cord-009571-mygj2nd4 1435 26 ( ( -LRB- cord-009571-mygj2nd4 1435 27 PWM PWM NNP cord-009571-mygj2nd4 1435 28 ) ) -RRB- cord-009571-mygj2nd4 1435 29 . . . cord-009571-mygj2nd4 1436 1 PBL PBL NNP cord-009571-mygj2nd4 1436 2 isolated isolate VBN cord-009571-mygj2nd4 1436 3 from from IN cord-009571-mygj2nd4 1436 4 5 5 CD cord-009571-mygj2nd4 1436 5 patients patient NNS cord-009571-mygj2nd4 1436 6 with with IN cord-009571-mygj2nd4 1436 7 SLE SLE NNP cord-009571-mygj2nd4 1436 8 and and CC cord-009571-mygj2nd4 1436 9 5 5 CD cord-009571-mygj2nd4 1436 10 controls control NNS cord-009571-mygj2nd4 1436 11 were be VBD cord-009571-mygj2nd4 1436 12 further further RB cord-009571-mygj2nd4 1436 13 separated separate VBN cord-009571-mygj2nd4 1436 14 into into IN cord-009571-mygj2nd4 1436 15 Tand Tand NNP cord-009571-mygj2nd4 1436 16 B b NN cord-009571-mygj2nd4 1436 17 - - HYPH cord-009571-mygj2nd4 1436 18 cell cell NN cord-009571-mygj2nd4 1436 19 enriched enrich VBN cord-009571-mygj2nd4 1436 20 fractions fraction NNS cord-009571-mygj2nd4 1436 21 by by IN cord-009571-mygj2nd4 1436 22 density density NN cord-009571-mygj2nd4 1436 23 sedimentation sedimentation NN cord-009571-mygj2nd4 1436 24 of of IN cord-009571-mygj2nd4 1436 25 spontaneous spontaneous JJ cord-009571-mygj2nd4 1436 26 rosettes rosette NNS cord-009571-mygj2nd4 1436 27 formed form VBN cord-009571-mygj2nd4 1436 28 by by IN cord-009571-mygj2nd4 1436 29 AET AET NNP cord-009571-mygj2nd4 1436 30 treated treat VBN cord-009571-mygj2nd4 1436 31 sheep sheep NN cord-009571-mygj2nd4 1436 32 red red JJ cord-009571-mygj2nd4 1436 33 blood blood NN cord-009571-mygj2nd4 1436 34 cells cell NNS cord-009571-mygj2nd4 1436 35 and and CC cord-009571-mygj2nd4 1436 36 T t NN cord-009571-mygj2nd4 1436 37 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 1436 38 . . . cord-009571-mygj2nd4 1437 1 A a DT cord-009571-mygj2nd4 1437 2 portion portion NN cord-009571-mygj2nd4 1437 3 of of IN cord-009571-mygj2nd4 1437 4 the the DT cord-009571-mygj2nd4 1437 5 T t NN cord-009571-mygj2nd4 1437 6 - - HYPH cord-009571-mygj2nd4 1437 7 cell cell NN cord-009571-mygj2nd4 1437 8 fraction fraction NN cord-009571-mygj2nd4 1437 9 was be VBD cord-009571-mygj2nd4 1437 10 irradiated irradiate VBN cord-009571-mygj2nd4 1437 11 with with IN cord-009571-mygj2nd4 1437 12 3000 3000 CD cord-009571-mygj2nd4 1437 13 rads rad NNS cord-009571-mygj2nd4 1437 14 to to TO cord-009571-mygj2nd4 1437 15 inactivate inactivate VB cord-009571-mygj2nd4 1437 16 were be VBD cord-009571-mygj2nd4 1437 17 cultured culture VBN cord-009571-mygj2nd4 1437 18 with with IN cord-009571-mygj2nd4 1437 19 normal normal JJ cord-009571-mygj2nd4 1437 20 or or CC cord-009571-mygj2nd4 1437 21 SLE sle NN cord-009571-mygj2nd4 1437 22 - - HYPH cord-009571-mygj2nd4 1437 23 B b NN cord-009571-mygj2nd4 1437 24 cells cell NNS cord-009571-mygj2nd4 1437 25 ( ( -LRB- cord-009571-mygj2nd4 1437 26 0.4 0.4 CD cord-009571-mygj2nd4 1437 27 X x NN cord-009571-mygj2nd4 1437 28 IV IV NNP cord-009571-mygj2nd4 1437 29 ) ) -RRB- cord-009571-mygj2nd4 1437 30 at at IN cord-009571-mygj2nd4 1437 31 ratios ratio NNS cord-009571-mygj2nd4 1438 1 These these DT cord-009571-mygj2nd4 1438 2 studies study NNS cord-009571-mygj2nd4 1438 3 show show VBP cord-009571-mygj2nd4 1438 4 that that IN cord-009571-mygj2nd4 1438 5 SLE SLE NNP cord-009571-mygj2nd4 1438 6 - - HYPH cord-009571-mygj2nd4 1438 7 B b NN cord-009571-mygj2nd4 1438 8 cells cell NNS cord-009571-mygj2nd4 1438 9 from from IN cord-009571-mygj2nd4 1438 10 some some DT cord-009571-mygj2nd4 1438 11 patients patient NNS cord-009571-mygj2nd4 1438 12 are be VBP cord-009571-mygj2nd4 1438 13 capable capable JJ cord-009571-mygj2nd4 1438 14 of of IN cord-009571-mygj2nd4 1438 15 synthesizing synthesize VBG cord-009571-mygj2nd4 1438 16 anti anti JJ cord-009571-mygj2nd4 1438 17 - - JJ cord-009571-mygj2nd4 1438 18 DNA dna NN cord-009571-mygj2nd4 1438 19 which which WDT cord-009571-mygj2nd4 1438 20 is be VBZ cord-009571-mygj2nd4 1438 21 best well RBS cord-009571-mygj2nd4 1438 22 demonstrated demonstrate VBN cord-009571-mygj2nd4 1438 23 in in IN cord-009571-mygj2nd4 1438 24 co co NN cord-009571-mygj2nd4 1438 25 - - NN cord-009571-mygj2nd4 1438 26 culture culture NN cord-009571-mygj2nd4 1438 27 with with IN cord-009571-mygj2nd4 1438 28 suppressor suppressor NN cord-009571-mygj2nd4 1438 29 inactivated inactivate VBN cord-009571-mygj2nd4 1438 30 , , , cord-009571-mygj2nd4 1438 31 irradiated irradiate VBN cord-009571-mygj2nd4 1438 32 T t NN cord-009571-mygj2nd4 1438 33 cells cell NNS cord-009571-mygj2nd4 1438 34 . . . cord-009571-mygj2nd4 1439 1 Normal normal JJ cord-009571-mygj2nd4 1439 2 - - HYPH cord-009571-mygj2nd4 1439 3 T t NN cord-009571-mygj2nd4 1439 4 cells cell NNS cord-009571-mygj2nd4 1439 5 suppress suppress VBP cord-009571-mygj2nd4 1439 6 the the DT cord-009571-mygj2nd4 1439 7 response response NN cord-009571-mygj2nd4 1439 8 , , , cord-009571-mygj2nd4 1439 9 whereas whereas IN cord-009571-mygj2nd4 1439 10 suppression suppression NN cord-009571-mygj2nd4 1439 11 exerted exert VBN cord-009571-mygj2nd4 1439 12 by by IN cord-009571-mygj2nd4 1439 13 SLE SLE NNP cord-009571-mygj2nd4 1439 14 - - HYPH cord-009571-mygj2nd4 1439 15 T T NNP cord-009571-mygj2nd4 1439 16 cells cell NNS cord-009571-mygj2nd4 1439 17 is be VBZ cord-009571-mygj2nd4 1439 18 variable variable JJ cord-009571-mygj2nd4 1439 19 from from IN cord-009571-mygj2nd4 1439 20 patient patient NN cord-009571-mygj2nd4 1439 21 to to IN cord-009571-mygj2nd4 1439 22 patient patient NN cord-009571-mygj2nd4 1439 23 . . . cord-009571-mygj2nd4 1440 1 Anti anti JJ cord-009571-mygj2nd4 1440 2 - - JJ cord-009571-mygj2nd4 1440 3 DNA DNA NNP cord-009571-mygj2nd4 1440 4 _SP cord-009571-mygj2nd4 1440 5 The the DT cord-009571-mygj2nd4 1440 6 antibody antibody NN cord-009571-mygj2nd4 1440 7 produced produce VBN cord-009571-mygj2nd4 1440 8 by by IN cord-009571-mygj2nd4 1440 9 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1440 10 arthritis arthritis NN cord-009571-mygj2nd4 1440 11 ( ( -LRB- cord-009571-mygj2nd4 1440 12 RA RA NNP cord-009571-mygj2nd4 1440 13 ) ) -RRB- cord-009571-mygj2nd4 1440 14 synovial synovial JJ cord-009571-mygj2nd4 1440 15 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 1440 16 may may MD cord-009571-mygj2nd4 1440 17 be be VB cord-009571-mygj2nd4 1440 18 directed direct VBN cord-009571-mygj2nd4 1440 19 at at IN cord-009571-mygj2nd4 1440 20 a a DT cord-009571-mygj2nd4 1440 21 uniquejoint uniquejoint NN cord-009571-mygj2nd4 1440 22 antigen antigen NN cord-009571-mygj2nd4 1440 23 inciting incite VBG cord-009571-mygj2nd4 1440 24 the the DT cord-009571-mygj2nd4 1440 25 inflammation inflammation NN cord-009571-mygj2nd4 1440 26 , , , cord-009571-mygj2nd4 1440 27 and and CC cord-009571-mygj2nd4 1440 28 thus thus RB cord-009571-mygj2nd4 1440 29 may may MD cord-009571-mygj2nd4 1440 30 be be VB cord-009571-mygj2nd4 1440 31 useful useful JJ cord-009571-mygj2nd4 1440 32 to to TO cord-009571-mygj2nd4 1440 33 identify identify VB cord-009571-mygj2nd4 1440 34 the the DT cord-009571-mygj2nd4 1440 35 antigen antigen NN cord-009571-mygj2nd4 1440 36 . . . cord-009571-mygj2nd4 1441 1 We -PRON- PRP cord-009571-mygj2nd4 1441 2 have have VBP cord-009571-mygj2nd4 1441 3 made make VBN cord-009571-mygj2nd4 1441 4 permanent permanent JJ cord-009571-mygj2nd4 1441 5 R R NNP cord-009571-mygj2nd4 1441 6 A a DT cord-009571-mygj2nd4 1441 7 synovial synovial JJ cord-009571-mygj2nd4 1441 8 lymphoblastoid lymphoblastoid NN cord-009571-mygj2nd4 1441 9 cell cell NN cord-009571-mygj2nd4 1441 10 lines line NNS cord-009571-mygj2nd4 1441 11 capable capable JJ cord-009571-mygj2nd4 1441 12 of of IN cord-009571-mygj2nd4 1441 13 producing produce VBG cord-009571-mygj2nd4 1441 14 unlimited unlimited JJ cord-009571-mygj2nd4 1441 15 quantities quantity NNS cord-009571-mygj2nd4 1441 16 of of IN cord-009571-mygj2nd4 1441 17 antibody antibody NN cord-009571-mygj2nd4 1441 18 . . . cord-009571-mygj2nd4 1442 1 R r LS cord-009571-mygj2nd4 1442 2 A a DT cord-009571-mygj2nd4 1442 3 synovial synovial JJ cord-009571-mygj2nd4 1442 4 membranes membrane NNS cord-009571-mygj2nd4 1442 5 were be VBD cord-009571-mygj2nd4 1442 6 obtained obtain VBN cord-009571-mygj2nd4 1442 7 surgically surgically RB cord-009571-mygj2nd4 1442 8 , , , cord-009571-mygj2nd4 1442 9 finely finely RB cord-009571-mygj2nd4 1442 10 minced mince VBN cord-009571-mygj2nd4 1442 11 in in IN cord-009571-mygj2nd4 1442 12 medium medium NN cord-009571-mygj2nd4 1442 13 ( ( -LRB- cord-009571-mygj2nd4 1442 14 RPMI RPMI NNP cord-009571-mygj2nd4 1442 15 1640 1640 CD cord-009571-mygj2nd4 1443 1 , , , cord-009571-mygj2nd4 1443 2 20 20 CD cord-009571-mygj2nd4 1443 3 % % NN cord-009571-mygj2nd4 1443 4 fetal fetal JJ cord-009571-mygj2nd4 1443 5 calf calf NN cord-009571-mygj2nd4 1443 6 serum serum NN cord-009571-mygj2nd4 1443 7 , , , cord-009571-mygj2nd4 1443 8 glutamine glutamine NN cord-009571-mygj2nd4 1443 9 , , , cord-009571-mygj2nd4 1443 10 antibiotics antibiotic NNS cord-009571-mygj2nd4 1443 11 ) ) -RRB- cord-009571-mygj2nd4 1443 12 , , , cord-009571-mygj2nd4 1443 13 placed place VBN cord-009571-mygj2nd4 1443 14 in in IN cord-009571-mygj2nd4 1443 15 60 60 CD cord-009571-mygj2nd4 1443 16 mm mm NNP cord-009571-mygj2nd4 1443 17 Linbro Linbro NNP cord-009571-mygj2nd4 1443 18 plates plate NNS cord-009571-mygj2nd4 1443 19 , , , cord-009571-mygj2nd4 1443 20 infected infect VBN cord-009571-mygj2nd4 1443 21 with with IN cord-009571-mygj2nd4 1443 22 Epstein Epstein NNP cord-009571-mygj2nd4 1443 23 - - HYPH cord-009571-mygj2nd4 1443 24 Barr Barr NNP cord-009571-mygj2nd4 1443 25 virus virus NN cord-009571-mygj2nd4 1443 26 , , , cord-009571-mygj2nd4 1443 27 incubated incubate VBN cord-009571-mygj2nd4 1443 28 ( ( -LRB- cord-009571-mygj2nd4 1443 29 37OC 37oc CD cord-009571-mygj2nd4 1443 30 , , , cord-009571-mygj2nd4 1443 31 air air NN cord-009571-mygj2nd4 1443 32 + + SYM cord-009571-mygj2nd4 1443 33 5 5 CD cord-009571-mygj2nd4 1443 34 % % NN cord-009571-mygj2nd4 1443 35 CO co NN cord-009571-mygj2nd4 1443 36 , , , cord-009571-mygj2nd4 1443 37 ) ) -RRB- cord-009571-mygj2nd4 1443 38 and and CC cord-009571-mygj2nd4 1443 39 fed feed VBD cord-009571-mygj2nd4 1443 40 weekly weekly RB cord-009571-mygj2nd4 1443 41 . . . cord-009571-mygj2nd4 1444 1 Typical typical JJ cord-009571-mygj2nd4 1444 2 lymphoblastoid lymphoblastoid NN cord-009571-mygj2nd4 1444 3 cell cell NN cord-009571-mygj2nd4 1444 4 lines line NNS cord-009571-mygj2nd4 1444 5 developed develop VBN cord-009571-mygj2nd4 1444 6 in in IN cord-009571-mygj2nd4 1444 7 13 13 CD cord-009571-mygj2nd4 1444 8 of of IN cord-009571-mygj2nd4 1444 9 43 43 CD cord-009571-mygj2nd4 1444 10 ( ( -LRB- cord-009571-mygj2nd4 1444 11 32 32 CD cord-009571-mygj2nd4 1444 12 % % NN cord-009571-mygj2nd4 1444 13 ) ) -RRB- cord-009571-mygj2nd4 1444 14 cultures culture NNS cord-009571-mygj2nd4 1444 15 after after IN cord-009571-mygj2nd4 1444 16 a a DT cord-009571-mygj2nd4 1444 17 mean mean JJ cord-009571-mygj2nd4 1444 18 33 33 CD cord-009571-mygj2nd4 1444 19 days day NNS cord-009571-mygj2nd4 1444 20 , , , cord-009571-mygj2nd4 1444 21 range range VBP cord-009571-mygj2nd4 1444 22 18 18 CD cord-009571-mygj2nd4 1444 23 - - SYM cord-009571-mygj2nd4 1444 24 53 53 CD cord-009571-mygj2nd4 1444 25 . . . cord-009571-mygj2nd4 1445 1 Once once RB cord-009571-mygj2nd4 1445 2 established establish VBN cord-009571-mygj2nd4 1445 3 , , , cord-009571-mygj2nd4 1445 4 the the DT cord-009571-mygj2nd4 1445 5 cell cell NN cord-009571-mygj2nd4 1445 6 lines line NNS cord-009571-mygj2nd4 1445 7 were be VBD cord-009571-mygj2nd4 1445 8 put put VBN cord-009571-mygj2nd4 1445 9 in in IN cord-009571-mygj2nd4 1445 10 large large JJ cord-009571-mygj2nd4 1445 11 flasks flask NNS cord-009571-mygj2nd4 1445 12 and and CC cord-009571-mygj2nd4 1445 13 medium medium NN cord-009571-mygj2nd4 1445 14 changed change VBD cord-009571-mygj2nd4 1445 15 completely completely RB cord-009571-mygj2nd4 1445 16 3 3 CD cord-009571-mygj2nd4 1445 17 times time NNS cord-009571-mygj2nd4 1445 18 a a DT cord-009571-mygj2nd4 1445 19 week week NN cord-009571-mygj2nd4 1445 20 . . . cord-009571-mygj2nd4 1446 1 Eight eight CD cord-009571-mygj2nd4 1446 2 of of IN cord-009571-mygj2nd4 1446 3 the the DT cord-009571-mygj2nd4 1446 4 13 13 CD cord-009571-mygj2nd4 1446 5 permanent permanent JJ cord-009571-mygj2nd4 1446 6 lines line NNS cord-009571-mygj2nd4 1446 7 were be VBD cord-009571-mygj2nd4 1446 8 lost lose VBN cord-009571-mygj2nd4 1446 9 after after IN cord-009571-mygj2nd4 1446 10 a a DT cord-009571-mygj2nd4 1446 11 mean mean JJ cord-009571-mygj2nd4 1446 12 duration duration NN cord-009571-mygj2nd4 1446 13 of of IN cord-009571-mygj2nd4 1446 14 54 54 CD cord-009571-mygj2nd4 1446 15 days day NNS cord-009571-mygj2nd4 1446 16 ( ( -LRB- cord-009571-mygj2nd4 1446 17 range range VBP cord-009571-mygj2nd4 1446 18 7 7 CD cord-009571-mygj2nd4 1446 19 - - SYM cord-009571-mygj2nd4 1446 20 120 120 CD cord-009571-mygj2nd4 1446 21 ) ) -RRB- cord-009571-mygj2nd4 1446 22 due due IN cord-009571-mygj2nd4 1446 23 to to IN cord-009571-mygj2nd4 1446 24 bacterial bacterial JJ cord-009571-mygj2nd4 1446 25 contamination contamination NN cord-009571-mygj2nd4 1446 26 or or CC cord-009571-mygj2nd4 1446 27 poor poor JJ cord-009571-mygj2nd4 1446 28 viability viability NN cord-009571-mygj2nd4 1446 29 . . . cord-009571-mygj2nd4 1447 1 The the DT cord-009571-mygj2nd4 1447 2 latter latter JJ cord-009571-mygj2nd4 1447 3 was be VBD cord-009571-mygj2nd4 1447 4 due due JJ cord-009571-mygj2nd4 1447 5 to to IN cord-009571-mygj2nd4 1447 6 suboptimal suboptimal JJ cord-009571-mygj2nd4 1447 7 growth growth NN cord-009571-mygj2nd4 1447 8 support support NN cord-009571-mygj2nd4 1447 9 by by IN cord-009571-mygj2nd4 1447 10 specific specific JJ cord-009571-mygj2nd4 1447 11 lots lot NNS cord-009571-mygj2nd4 1447 12 of of IN cord-009571-mygj2nd4 1447 13 RPMI RPMI NNP cord-009571-mygj2nd4 1447 14 or or CC cord-009571-mygj2nd4 1447 15 serum serum NN cord-009571-mygj2nd4 1447 16 ; ; : cord-009571-mygj2nd4 1447 17 subsequently subsequently RB cord-009571-mygj2nd4 1447 18 these these DT cord-009571-mygj2nd4 1447 19 were be VBD cord-009571-mygj2nd4 1447 20 pretested preteste VBN cord-009571-mygj2nd4 1447 21 . . . cord-009571-mygj2nd4 1448 1 The the DT cord-009571-mygj2nd4 1448 2 5 5 CD cord-009571-mygj2nd4 1448 3 remaining remain VBG cord-009571-mygj2nd4 1448 4 lymphoblastoid lymphoblastoid NNP cord-009571-mygj2nd4 1448 5 lines line NNS cord-009571-mygj2nd4 1448 6 now now RB cord-009571-mygj2nd4 1448 7 have have VBP cord-009571-mygj2nd4 1448 8 a a DT cord-009571-mygj2nd4 1448 9 mean mean JJ cord-009571-mygj2nd4 1448 10 duration duration NN cord-009571-mygj2nd4 1448 11 of of IN cord-009571-mygj2nd4 1448 12 159 159 CD cord-009571-mygj2nd4 1448 13 days day NNS cord-009571-mygj2nd4 1448 14 ( ( -LRB- cord-009571-mygj2nd4 1448 15 range range VBP cord-009571-mygj2nd4 1448 16 120 120 CD cord-009571-mygj2nd4 1448 17 - - HYPH cord-009571-mygj2nd4 1448 18 210 210 CD cord-009571-mygj2nd4 1448 19 ) ) -RRB- cord-009571-mygj2nd4 1448 20 , , , cord-009571-mygj2nd4 1448 21 during during IN cord-009571-mygj2nd4 1448 22 which which WDT cord-009571-mygj2nd4 1448 23 their -PRON- PRP$ cord-009571-mygj2nd4 1448 24 mean mean JJ cord-009571-mygj2nd4 1448 25 volume volume NN cord-009571-mygj2nd4 1448 26 was be VBD cord-009571-mygj2nd4 1448 27 207 207 CD cord-009571-mygj2nd4 1448 28 ml ml NN cord-009571-mygj2nd4 1448 29 ( ( -LRB- cord-009571-mygj2nd4 1448 30 range range VB cord-009571-mygj2nd4 1448 31 98 98 CD cord-009571-mygj2nd4 1448 32 - - SYM cord-009571-mygj2nd4 1448 33 332 332 CD cord-009571-mygj2nd4 1448 34 ) ) -RRB- cord-009571-mygj2nd4 1448 35 . . . cord-009571-mygj2nd4 1449 1 Maximum maximum JJ cord-009571-mygj2nd4 1449 2 volume volume NN cord-009571-mygj2nd4 1449 3 was be VBD cord-009571-mygj2nd4 1449 4 1.4 1.4 CD cord-009571-mygj2nd4 1449 5 liters liter NNS cord-009571-mygj2nd4 1449 6 , , , cord-009571-mygj2nd4 1449 7 but but CC cord-009571-mygj2nd4 1449 8 could could MD cord-009571-mygj2nd4 1449 9 be be VB cord-009571-mygj2nd4 1449 10 expanded expand VBN cord-009571-mygj2nd4 1449 11 indefinitely indefinitely RB cord-009571-mygj2nd4 1449 12 in in IN cord-009571-mygj2nd4 1449 13 2 2 CD cord-009571-mygj2nd4 1449 14 liters liter NNS cord-009571-mygj2nd4 1449 15 or or CC cord-009571-mygj2nd4 1449 16 larger large JJR cord-009571-mygj2nd4 1449 17 flasks flask NNS cord-009571-mygj2nd4 1449 18 on on IN cord-009571-mygj2nd4 1449 19 shaker shaker NN cord-009571-mygj2nd4 1449 20 platforms platform NNS cord-009571-mygj2nd4 1449 21 at at IN cord-009571-mygj2nd4 1449 22 low low JJ cord-009571-mygj2nd4 1449 23 speed speed NN cord-009571-mygj2nd4 1449 24 . . . cord-009571-mygj2nd4 1450 1 Mean mean JJ cord-009571-mygj2nd4 1450 2 cell cell NN cord-009571-mygj2nd4 1450 3 doubling double VBG cord-009571-mygj2nd4 1450 4 time time NN cord-009571-mygj2nd4 1450 5 was be VBD cord-009571-mygj2nd4 1450 6 34 34 CD cord-009571-mygj2nd4 1450 7 hours hour NNS cord-009571-mygj2nd4 1450 8 , , , cord-009571-mygj2nd4 1450 9 range range VBP cord-009571-mygj2nd4 1450 10 24 24 CD cord-009571-mygj2nd4 1450 11 - - SYM cord-009571-mygj2nd4 1450 12 48 48 CD cord-009571-mygj2nd4 1450 13 . . . cord-009571-mygj2nd4 1451 1 IgG IgG NNP cord-009571-mygj2nd4 1451 2 concentration concentration NN cord-009571-mygj2nd4 1451 3 in in IN cord-009571-mygj2nd4 1451 4 harvested harvest VBN cord-009571-mygj2nd4 1451 5 supernatant supernatant JJ cord-009571-mygj2nd4 1451 6 medium medium NN cord-009571-mygj2nd4 1451 7 was be VBD cord-009571-mygj2nd4 1451 8 measured measure VBN cord-009571-mygj2nd4 1451 9 sequentially sequentially RB cord-009571-mygj2nd4 1451 10 by by IN cord-009571-mygj2nd4 1451 11 a a DT cord-009571-mygj2nd4 1451 12 radioimmunoassay radioimmunoassay NN cord-009571-mygj2nd4 1451 13 described describe VBN cord-009571-mygj2nd4 1451 14 previously previously RB cord-009571-mygj2nd4 1451 15 . . . cord-009571-mygj2nd4 1452 1 Mean mean JJ cord-009571-mygj2nd4 1452 2 IgG igg NN cord-009571-mygj2nd4 1452 3 production production NN cord-009571-mygj2nd4 1452 4 by by IN cord-009571-mygj2nd4 1452 5 each each DT cord-009571-mygj2nd4 1452 6 line line NN cord-009571-mygj2nd4 1452 7 was be VBD cord-009571-mygj2nd4 1452 8 55 55 CD cord-009571-mygj2nd4 1452 9 , , , cord-009571-mygj2nd4 1452 10 246,420,426 246,420,426 CD cord-009571-mygj2nd4 1452 11 , , , cord-009571-mygj2nd4 1452 12 and and CC cord-009571-mygj2nd4 1452 13 1405 1405 CD cord-009571-mygj2nd4 1452 14 pg pg NNP cord-009571-mygj2nd4 1452 15 IgG IgG NNP cord-009571-mygj2nd4 1452 16 / / SYM cord-009571-mygj2nd4 1452 17 day day NN cord-009571-mygj2nd4 1452 18 , , , cord-009571-mygj2nd4 1452 19 decreasing decrease VBG cord-009571-mygj2nd4 1452 20 slowly slowly RB cord-009571-mygj2nd4 1452 21 with with IN cord-009571-mygj2nd4 1452 22 time time NN cord-009571-mygj2nd4 1452 23 . . . cord-009571-mygj2nd4 1453 1 Adjusted adjust VBN cord-009571-mygj2nd4 1453 2 for for IN cord-009571-mygj2nd4 1453 3 cell cell NN cord-009571-mygj2nd4 1453 4 concentration concentration NN cord-009571-mygj2nd4 1453 5 , , , cord-009571-mygj2nd4 1453 6 mean mean JJ cord-009571-mygj2nd4 1453 7 production production NN cord-009571-mygj2nd4 1453 8 was be VBD cord-009571-mygj2nd4 1453 9 0.9 0.9 CD cord-009571-mygj2nd4 1453 10 , , , cord-009571-mygj2nd4 1453 11 3.9 3.9 CD cord-009571-mygj2nd4 1453 12 , , , cord-009571-mygj2nd4 1453 13 4.6 4.6 CD cord-009571-mygj2nd4 1453 14 , , , cord-009571-mygj2nd4 1453 15 5.8 5.8 CD cord-009571-mygj2nd4 1453 16 , , , cord-009571-mygj2nd4 1453 17 and and CC cord-009571-mygj2nd4 1453 18 9.7 9.7 CD cord-009571-mygj2nd4 1453 19 pg pg NNP cord-009571-mygj2nd4 1453 20 IgG IgG NNP cord-009571-mygj2nd4 1453 21 / / SYM cord-009571-mygj2nd4 1453 22 IV IV NNP cord-009571-mygj2nd4 1453 23 cells cell NNS cord-009571-mygj2nd4 1453 24 / / SYM cord-009571-mygj2nd4 1453 25 day day NN cord-009571-mygj2nd4 1453 26 . . . cord-009571-mygj2nd4 1454 1 Total total JJ cord-009571-mygj2nd4 1454 2 production production NN cord-009571-mygj2nd4 1454 3 to to IN cord-009571-mygj2nd4 1454 4 date date NN cord-009571-mygj2nd4 1454 5 was be VBD cord-009571-mygj2nd4 1454 6 2.418 2.418 CD cord-009571-mygj2nd4 1454 7 , , , cord-009571-mygj2nd4 1454 8 29.061 29.061 CD cord-009571-mygj2nd4 1454 9 , , , cord-009571-mygj2nd4 1454 10 36.684 36.684 CD cord-009571-mygj2nd4 1454 11 , , , cord-009571-mygj2nd4 1454 12 50.768 50.768 CD cord-009571-mygj2nd4 1454 13 , , , cord-009571-mygj2nd4 1454 14 and and CC cord-009571-mygj2nd4 1454 15 59 59 CD cord-009571-mygj2nd4 1454 16 .0 .0 CD cord-009571-mygj2nd4 1454 17 milligrams milligram NNS cord-009571-mygj2nd4 1454 18 . . . cord-009571-mygj2nd4 1455 1 The the DT cord-009571-mygj2nd4 1455 2 culture culture NN cord-009571-mygj2nd4 1455 3 producing produce VBG cord-009571-mygj2nd4 1455 4 the the DT cord-009571-mygj2nd4 1455 5 lowest low JJS cord-009571-mygj2nd4 1455 6 amount amount NN cord-009571-mygj2nd4 1455 7 may may MD cord-009571-mygj2nd4 1455 8 be be VB cord-009571-mygj2nd4 1455 9 producing produce VBG cord-009571-mygj2nd4 1455 10 a a DT cord-009571-mygj2nd4 1455 11 predominance predominance NN cord-009571-mygj2nd4 1455 12 of of IN cord-009571-mygj2nd4 1455 13 another another DT cord-009571-mygj2nd4 1455 14 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 1455 15 type type NN cord-009571-mygj2nd4 1455 16 . . . cord-009571-mygj2nd4 1456 1 In in IN cord-009571-mygj2nd4 1456 2 3 3 CD cord-009571-mygj2nd4 1456 3 of of IN cord-009571-mygj2nd4 1456 4 5 5 CD cord-009571-mygj2nd4 1456 5 lines line NNS cord-009571-mygj2nd4 1456 6 IgG IgG NNP cord-009571-mygj2nd4 1456 7 production production NN cord-009571-mygj2nd4 1456 8 tended tend VBD cord-009571-mygj2nd4 1456 9 to to TO cord-009571-mygj2nd4 1456 10 be be VB cord-009571-mygj2nd4 1456 11 significantly significantly RB cord-009571-mygj2nd4 1456 12 higher high JJR cord-009571-mygj2nd4 1456 13 when when WRB cord-009571-mygj2nd4 1456 14 cell cell NN cord-009571-mygj2nd4 1456 15 concentration concentration NN cord-009571-mygj2nd4 1456 16 was be VBD cord-009571-mygj2nd4 1456 17 lower low JJR cord-009571-mygj2nd4 1456 18 ( ( -LRB- cord-009571-mygj2nd4 1456 19 r r NN cord-009571-mygj2nd4 1456 20 = = NN cord-009571-mygj2nd4 1456 21 0.465 0.465 CD cord-009571-mygj2nd4 1456 22 -0.673 -0.673 XX cord-009571-mygj2nd4 1456 23 ; ; : cord-009571-mygj2nd4 1456 24 P p NN cord-009571-mygj2nd4 1456 25 < < XX cord-009571-mygj2nd4 1456 26 0.001 0.001 CD cord-009571-mygj2nd4 1456 27 ) ) -RRB- cord-009571-mygj2nd4 1456 28 . . . cord-009571-mygj2nd4 1457 1 These these DT cord-009571-mygj2nd4 1457 2 RA RA NNP cord-009571-mygj2nd4 1457 3 lines line NNS cord-009571-mygj2nd4 1457 4 produced produce VBD cord-009571-mygj2nd4 1457 5 more more JJR cord-009571-mygj2nd4 1457 6 IgG igg NN cord-009571-mygj2nd4 1457 7 than than IN cord-009571-mygj2nd4 1457 8 previously previously RB cord-009571-mygj2nd4 1457 9 reported report VBN cord-009571-mygj2nd4 1457 10 for for IN cord-009571-mygj2nd4 1457 11 lymphoblastoid lymphoblastoid NNP cord-009571-mygj2nd4 1457 12 lines line NNS cord-009571-mygj2nd4 1457 13 derived derive VBN cord-009571-mygj2nd4 1457 14 from from IN cord-009571-mygj2nd4 1457 15 other other JJ cord-009571-mygj2nd4 1457 16 human human JJ cord-009571-mygj2nd4 1457 17 tissues tissue NNS cord-009571-mygj2nd4 1457 18 ( ( -LRB- cord-009571-mygj2nd4 1457 19 1 1 CD cord-009571-mygj2nd4 1457 20 - - SYM cord-009571-mygj2nd4 1457 21 3 3 CD cord-009571-mygj2nd4 1457 22 Bg Bg NNP cord-009571-mygj2nd4 1457 23 / / SYM cord-009571-mygj2nd4 1457 24 lP lp NN cord-009571-mygj2nd4 1457 25 cells cell NNS cord-009571-mygj2nd4 1457 26 / / SYM cord-009571-mygj2nd4 1457 27 day day NN cord-009571-mygj2nd4 1457 28 ) ) -RRB- cord-009571-mygj2nd4 1457 29 . . . cord-009571-mygj2nd4 1458 1 They -PRON- PRP cord-009571-mygj2nd4 1458 2 also also RB cord-009571-mygj2nd4 1458 3 produced produce VBD cord-009571-mygj2nd4 1458 4 5 5 CD cord-009571-mygj2nd4 1458 5 - - SYM cord-009571-mygj2nd4 1458 6 10 10 CD cord-009571-mygj2nd4 1458 7 times time NNS cord-009571-mygj2nd4 1458 8 more more JJR cord-009571-mygj2nd4 1458 9 IgG igg NN cord-009571-mygj2nd4 1458 10 than than IN cord-009571-mygj2nd4 1458 11 our -PRON- PRP$ cord-009571-mygj2nd4 1458 12 previous previous JJ cord-009571-mygj2nd4 1458 13 batch batch NN cord-009571-mygj2nd4 1458 14 organ organ NN cord-009571-mygj2nd4 1458 15 cultures culture NNS cord-009571-mygj2nd4 1458 16 of of IN cord-009571-mygj2nd4 1458 17 RA RA NNP cord-009571-mygj2nd4 1458 18 synovia synovia NNP cord-009571-mygj2nd4 1458 19 . . . cord-009571-mygj2nd4 1459 1 Their -PRON- PRP$ cord-009571-mygj2nd4 1459 2 increased increase VBN cord-009571-mygj2nd4 1459 3 IgG igg NN cord-009571-mygj2nd4 1459 4 production production NN cord-009571-mygj2nd4 1459 5 may may MD cord-009571-mygj2nd4 1459 6 be be VB cord-009571-mygj2nd4 1459 7 due due JJ cord-009571-mygj2nd4 1459 8 to to IN cord-009571-mygj2nd4 1459 9 improved improved JJ cord-009571-mygj2nd4 1459 10 culture culture NN cord-009571-mygj2nd4 1459 11 conditions condition NNS cord-009571-mygj2nd4 1459 12 and/or and/or CC cord-009571-mygj2nd4 1459 13 intrinsic intrinsic JJ cord-009571-mygj2nd4 1459 14 immunologic immunologic JJ cord-009571-mygj2nd4 1459 15 hyperactivity hyperactivity NN cord-009571-mygj2nd4 1459 16 of of IN cord-009571-mygj2nd4 1459 17 RA RA NNP cord-009571-mygj2nd4 1459 18 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 1459 19 . . . cord-009571-mygj2nd4 1460 1 These these DT cord-009571-mygj2nd4 1460 2 cultures culture NNS cord-009571-mygj2nd4 1460 3 may may MD cord-009571-mygj2nd4 1460 4 provide provide VB cord-009571-mygj2nd4 1460 5 an an DT cord-009571-mygj2nd4 1460 6 excellent excellent JJ cord-009571-mygj2nd4 1460 7 source source NN cord-009571-mygj2nd4 1460 8 of of IN cord-009571-mygj2nd4 1460 9 antibody antibody NN cord-009571-mygj2nd4 1460 10 specific specific JJ cord-009571-mygj2nd4 1460 11 for for IN cord-009571-mygj2nd4 1460 12 the the DT cord-009571-mygj2nd4 1460 13 antigen(s antigen(s NNP cord-009571-mygj2nd4 1460 14 ) ) -RRB- cord-009571-mygj2nd4 1461 1 inciting incite VBG cord-009571-mygj2nd4 1461 2 RA RA NNP cord-009571-mygj2nd4 1461 3 . . . cord-009571-mygj2nd4 1462 1 Recently recently RB cord-009571-mygj2nd4 1462 2 we -PRON- PRP cord-009571-mygj2nd4 1462 3 reported report VBD cord-009571-mygj2nd4 1462 4 that that IN cord-009571-mygj2nd4 1462 5 partial partial JJ cord-009571-mygj2nd4 1462 6 disuse disuse NN cord-009571-mygj2nd4 1462 7 of of IN cord-009571-mygj2nd4 1462 8 a a DT cord-009571-mygj2nd4 1462 9 joint joint NN cord-009571-mygj2nd4 1462 10 produced produce VBD cord-009571-mygj2nd4 1462 11 a a DT cord-009571-mygj2nd4 1462 12 defect defect NN cord-009571-mygj2nd4 1462 13 in in IN cord-009571-mygj2nd4 1462 14 proteoglycan proteoglycan NN cord-009571-mygj2nd4 1462 15 ( ( -LRB- cord-009571-mygj2nd4 1462 16 PG pg NN cord-009571-mygj2nd4 1462 17 ) ) -RRB- cord-009571-mygj2nd4 1462 18 aggregation aggregation NN cord-009571-mygj2nd4 1462 19 in in IN cord-009571-mygj2nd4 1462 20 human human JJ cord-009571-mygj2nd4 1462 21 articular articular JJ cord-009571-mygj2nd4 1462 22 cartilage cartilage NN cord-009571-mygj2nd4 1462 23 indistinguishable indistinguishable JJ cord-009571-mygj2nd4 1462 24 from from IN cord-009571-mygj2nd4 1462 25 that that DT cord-009571-mygj2nd4 1462 26 seen see VBN cord-009571-mygj2nd4 1462 27 in in IN cord-009571-mygj2nd4 1462 28 osteoarthritis osteoarthritis NN cord-009571-mygj2nd4 1462 29 . . . cord-009571-mygj2nd4 1463 1 The the DT cord-009571-mygj2nd4 1463 2 present present JJ cord-009571-mygj2nd4 1463 3 study study NN cord-009571-mygj2nd4 1463 4 examines examine VBZ cord-009571-mygj2nd4 1463 5 the the DT cord-009571-mygj2nd4 1463 6 rapidity rapidity NN cord-009571-mygj2nd4 1463 7 with with IN cord-009571-mygj2nd4 1463 8 which which WDT cord-009571-mygj2nd4 1463 9 defective defective JJ cord-009571-mygj2nd4 1463 10 PG PG NNP cord-009571-mygj2nd4 1463 11 organization organization NN cord-009571-mygj2nd4 1463 12 develops develop VBZ cord-009571-mygj2nd4 1463 13 after after IN cord-009571-mygj2nd4 1463 14 total total JJ cord-009571-mygj2nd4 1463 15 immobilization immobilization NN cord-009571-mygj2nd4 1463 16 of of IN cord-009571-mygj2nd4 1463 17 a a DT cord-009571-mygj2nd4 1463 18 limb limb NN cord-009571-mygj2nd4 1463 19 , , , cord-009571-mygj2nd4 1463 20 and and CC cord-009571-mygj2nd4 1463 21 the the DT cord-009571-mygj2nd4 1463 22 reversibility reversibility NN cord-009571-mygj2nd4 1463 23 of of IN cord-009571-mygj2nd4 1463 24 the the DT cord-009571-mygj2nd4 1463 25 defect defect NN cord-009571-mygj2nd4 1463 26 . . . cord-009571-mygj2nd4 1464 1 The the DT cord-009571-mygj2nd4 1464 2 right right JJ cord-009571-mygj2nd4 1464 3 hind hind NN cord-009571-mygj2nd4 1464 4 limb limb NN cord-009571-mygj2nd4 1464 5 of of IN cord-009571-mygj2nd4 1464 6 dogs dog NNS cord-009571-mygj2nd4 1464 7 was be VBD cord-009571-mygj2nd4 1464 8 immobilized immobilize VBN cord-009571-mygj2nd4 1464 9 in in IN cord-009571-mygj2nd4 1464 10 a a DT cord-009571-mygj2nd4 1464 11 cast cast NN cord-009571-mygj2nd4 1464 12 for for IN cord-009571-mygj2nd4 1464 13 5 5 CD cord-009571-mygj2nd4 1464 14 days day NNS cord-009571-mygj2nd4 1464 15 to to IN cord-009571-mygj2nd4 1464 16 8 8 CD cord-009571-mygj2nd4 1464 17 weeks week NNS cord-009571-mygj2nd4 1464 18 , , , cord-009571-mygj2nd4 1464 19 at at IN cord-009571-mygj2nd4 1464 20 which which WDT cord-009571-mygj2nd4 1464 21 time time NN cord-009571-mygj2nd4 1464 22 the the DT cord-009571-mygj2nd4 1464 23 animals animal NNS cord-009571-mygj2nd4 1464 24 were be VBD cord-009571-mygj2nd4 1464 25 killed kill VBN cord-009571-mygj2nd4 1464 26 . . . cord-009571-mygj2nd4 1465 1 During during IN cord-009571-mygj2nd4 1465 2 this this DT cord-009571-mygj2nd4 1465 3 period period NN cord-009571-mygj2nd4 1465 4 the the DT cord-009571-mygj2nd4 1465 5 dogs dog NNS cord-009571-mygj2nd4 1465 6 ambulated ambulate VBN cord-009571-mygj2nd4 1465 7 freely freely RB cord-009571-mygj2nd4 1465 8 on on IN cord-009571-mygj2nd4 1465 9 3 3 CD cord-009571-mygj2nd4 1465 10 legs leg NNS cord-009571-mygj2nd4 1465 11 but but CC cord-009571-mygj2nd4 1465 12 bore bear VBD cord-009571-mygj2nd4 1465 13 no no DT cord-009571-mygj2nd4 1465 14 weight weight NN cord-009571-mygj2nd4 1465 15 on on IN cord-009571-mygj2nd4 1465 16 the the DT cord-009571-mygj2nd4 1465 17 immobilized immobilized JJ cord-009571-mygj2nd4 1465 18 limb limb NN cord-009571-mygj2nd4 1465 19 . . . cord-009571-mygj2nd4 1466 1 In in IN cord-009571-mygj2nd4 1466 2 some some DT cord-009571-mygj2nd4 1466 3 cases case NNS cord-009571-mygj2nd4 1466 4 the the DT cord-009571-mygj2nd4 1466 5 cast cast NN cord-009571-mygj2nd4 1466 6 was be VBD cord-009571-mygj2nd4 1466 7 removed remove VBN cord-009571-mygj2nd4 1466 8 after after IN cord-009571-mygj2nd4 1466 9 6 6 CD cord-009571-mygj2nd4 1466 10 weeks week NNS cord-009571-mygj2nd4 1466 11 and and CC cord-009571-mygj2nd4 1466 12 the the DT cord-009571-mygj2nd4 1466 13 dogs dog NNS cord-009571-mygj2nd4 1466 14 then then RB cord-009571-mygj2nd4 1466 15 ambulated ambulate VBD cord-009571-mygj2nd4 1466 16 fully fully RB cord-009571-mygj2nd4 1466 17 for for IN cord-009571-mygj2nd4 1466 18 up up IN cord-009571-mygj2nd4 1466 19 to to TO cord-009571-mygj2nd4 1466 20 4 4 CD cord-009571-mygj2nd4 1466 21 weeks week NNS cord-009571-mygj2nd4 1466 22 prior prior RB cord-009571-mygj2nd4 1466 23 to to IN cord-009571-mygj2nd4 1466 24 sacrifice sacrifice NN cord-009571-mygj2nd4 1466 25 . . . cord-009571-mygj2nd4 1467 1 Cartilage cartilage NN cord-009571-mygj2nd4 1467 2 from from IN cord-009571-mygj2nd4 1467 3 the the DT cord-009571-mygj2nd4 1467 4 distal distal JJ cord-009571-mygj2nd4 1467 5 femur femur NN cord-009571-mygj2nd4 1467 6 of of IN cord-009571-mygj2nd4 1467 7 the the DT cord-009571-mygj2nd4 1467 8 immobilized immobilize VBN cord-009571-mygj2nd4 1467 9 and and CC cord-009571-mygj2nd4 1468 1 the the DT cord-009571-mygj2nd4 1468 2 contralateral contralateral JJ cord-009571-mygj2nd4 1468 3 control control NN cord-009571-mygj2nd4 1468 4 knees knee NNS cord-009571-mygj2nd4 1468 5 was be VBD cord-009571-mygj2nd4 1468 6 cultured culture VBN cord-009571-mygj2nd4 1468 7 for for IN cord-009571-mygj2nd4 1468 8 24 24 CD cord-009571-mygj2nd4 1468 9 hours hour NNS cord-009571-mygj2nd4 1468 10 in in IN cord-009571-mygj2nd4 1468 11 Ham Ham NNP cord-009571-mygj2nd4 1468 12 's 's POS cord-009571-mygj2nd4 1468 13 F-12 F-12 NNP cord-009571-mygj2nd4 1468 14 nutrient nutrient NN cord-009571-mygj2nd4 1468 15 mixture mixture NN cord-009571-mygj2nd4 1468 16 containing contain VBG cord-009571-mygj2nd4 1468 17 IWO IWO NNP cord-009571-mygj2nd4 1468 18 fetal fetal JJ cord-009571-mygj2nd4 1468 19 calf calf NN cord-009571-mygj2nd4 1468 20 serum serum NN cord-009571-mygj2nd4 1468 21 and and CC cord-009571-mygj2nd4 1468 22 86S0 86s0 CD cord-009571-mygj2nd4 1468 23 , , , cord-009571-mygj2nd4 1468 24 . . . cord-009571-mygj2nd4 1469 1 PGs pg NNS cord-009571-mygj2nd4 1469 2 were be VBD cord-009571-mygj2nd4 1469 3 extracted extract VBN cord-009571-mygj2nd4 1469 4 with with IN cord-009571-mygj2nd4 1469 5 4 4 CD cord-009571-mygj2nd4 1469 6 M M NNP cord-009571-mygj2nd4 1469 7 guanidinium guanidinium NN cord-009571-mygj2nd4 1469 8 chloride chloride NN cord-009571-mygj2nd4 1469 9 ( ( -LRB- cord-009571-mygj2nd4 1469 10 GuHCI GuHCI NNP cord-009571-mygj2nd4 1469 11 ) ) -RRB- cord-009571-mygj2nd4 1469 12 and and CC cord-009571-mygj2nd4 1469 13 purified purify VBN cord-009571-mygj2nd4 1469 14 by by IN cord-009571-mygj2nd4 1469 15 successive successive JJ cord-009571-mygj2nd4 1469 16 cesium cesium NN cord-009571-mygj2nd4 1469 17 chloride chloride NN cord-009571-mygj2nd4 1469 18 density density NN cord-009571-mygj2nd4 1469 19 gradient gradient NN cord-009571-mygj2nd4 1469 20 centrifugations centrifugation NNS cord-009571-mygj2nd4 1469 21 in in IN cord-009571-mygj2nd4 1469 22 0.4 0.4 CD cord-009571-mygj2nd4 1469 23 M M NNP cord-009571-mygj2nd4 1469 24 and and CC cord-009571-mygj2nd4 1469 25 4.0 4.0 CD cord-009571-mygj2nd4 1469 26 M M NNP cord-009571-mygj2nd4 1469 27 GuHCI GuHCI NNP cord-009571-mygj2nd4 1469 28 , , , cord-009571-mygj2nd4 1469 29 ie ie UH cord-009571-mygj2nd4 1469 30 , , , cord-009571-mygj2nd4 1469 31 under under IN cord-009571-mygj2nd4 1469 32 conditions condition NNS cord-009571-mygj2nd4 1469 33 favoring favor VBG cord-009571-mygj2nd4 1469 34 forma forma NN cord-009571-mygj2nd4 1469 35 - - HYPH cord-009571-mygj2nd4 1469 36 tion tion NN cord-009571-mygj2nd4 1469 37 of of IN cord-009571-mygj2nd4 1469 38 PG PG NNP cord-009571-mygj2nd4 1469 39 aggregates aggregate NNS cord-009571-mygj2nd4 1469 40 and and CC cord-009571-mygj2nd4 1469 41 disaggregation disaggregation NN cord-009571-mygj2nd4 1469 42 of of IN cord-009571-mygj2nd4 1469 43 PGs pg NNS cord-009571-mygj2nd4 1469 44 , , , cord-009571-mygj2nd4 1469 45 respectively respectively RB cord-009571-mygj2nd4 1469 46 . . . cord-009571-mygj2nd4 1470 1 After after IN cord-009571-mygj2nd4 1470 2 only only RB cord-009571-mygj2nd4 1470 3 5 5 CD cord-009571-mygj2nd4 1470 4 days day NNS cord-009571-mygj2nd4 1470 5 of of IN cord-009571-mygj2nd4 1470 6 immobilization immobilization NN cord-009571-mygj2nd4 1470 7 a6S0 a6S0 NNP cord-009571-mygj2nd4 1470 8 , , , cord-009571-mygj2nd4 1470 9 incorporation incorporation NN cord-009571-mygj2nd4 1470 10 into into IN cord-009571-mygj2nd4 1470 11 PGs pg NNS cord-009571-mygj2nd4 1470 12 was be VBD cord-009571-mygj2nd4 1470 13 suppressed suppress VBN cord-009571-mygj2nd4 1470 14 by by IN cord-009571-mygj2nd4 1470 15 5070 5070 CD cord-009571-mygj2nd4 1470 16 , , , cord-009571-mygj2nd4 1470 17 and and CC cord-009571-mygj2nd4 1470 18 this this DT cord-009571-mygj2nd4 1470 19 diminution diminution NN cord-009571-mygj2nd4 1470 20 in in IN cord-009571-mygj2nd4 1470 21 PG PG NNP cord-009571-mygj2nd4 1470 22 synthesis synthesis NN cord-009571-mygj2nd4 1470 23 persisted persist VBD cord-009571-mygj2nd4 1470 24 through through IN cord-009571-mygj2nd4 1470 25 8 8 CD cord-009571-mygj2nd4 1470 26 weeks week NNS cord-009571-mygj2nd4 1470 27 of of IN cord-009571-mygj2nd4 1470 28 immobilization immobilization NN cord-009571-mygj2nd4 1470 29 . . . cord-009571-mygj2nd4 1471 1 After after IN cord-009571-mygj2nd4 1471 2 3 3 CD cord-009571-mygj2nd4 1471 3 weeks week NNS cord-009571-mygj2nd4 1471 4 of of IN cord-009571-mygj2nd4 1471 5 immobilization immobilization NN cord-009571-mygj2nd4 1471 6 no no DT cord-009571-mygj2nd4 1471 7 evidence evidence NN cord-009571-mygj2nd4 1471 8 of of IN cord-009571-mygj2nd4 1471 9 PG PG NNP cord-009571-mygj2nd4 1471 10 aggregation aggregation NN cord-009571-mygj2nd4 1471 11 could could MD cord-009571-mygj2nd4 1471 12 be be VB cord-009571-mygj2nd4 1471 13 found find VBN cord-009571-mygj2nd4 1471 14 . . . cord-009571-mygj2nd4 1472 1 At at IN cord-009571-mygj2nd4 1472 2 that that DT cord-009571-mygj2nd4 1472 3 time time NN cord-009571-mygj2nd4 1472 4 PGs pg NNS cord-009571-mygj2nd4 1472 5 from from IN cord-009571-mygj2nd4 1472 6 the the DT cord-009571-mygj2nd4 1472 7 second second JJ cord-009571-mygj2nd4 1472 8 gradient gradient NN cord-009571-mygj2nd4 1472 9 were be VBD cord-009571-mygj2nd4 1472 10 the the DT cord-009571-mygj2nd4 1472 11 same same JJ cord-009571-mygj2nd4 1472 12 size size NN cord-009571-mygj2nd4 1472 13 as as IN cord-009571-mygj2nd4 1472 14 those those DT cord-009571-mygj2nd4 1472 15 from from IN cord-009571-mygj2nd4 1472 16 the the DT cord-009571-mygj2nd4 1472 17 first first JJ cord-009571-mygj2nd4 1472 18 gradient gradient NN cord-009571-mygj2nd4 1472 19 ( ( -LRB- cord-009571-mygj2nd4 1472 20 Sepharose Sepharose NNP cord-009571-mygj2nd4 1472 21 2B 2B NNP cord-009571-mygj2nd4 1472 22 K. K. NNP cord-009571-mygj2nd4 1472 23 , , , cord-009571-mygj2nd4 1472 24 = = SYM cord-009571-mygj2nd4 1472 25 0.63 0.63 CD cord-009571-mygj2nd4 1472 26 ) ) -RRB- cord-009571-mygj2nd4 1472 27 and and CC cord-009571-mygj2nd4 1472 28 showed show VBD cord-009571-mygj2nd4 1472 29 no no DT cord-009571-mygj2nd4 1472 30 shift shift NN cord-009571-mygj2nd4 1472 31 in in IN cord-009571-mygj2nd4 1472 32 their -PRON- PRP$ cord-009571-mygj2nd4 1472 33 Sepharose Sepharose NNP cord-009571-mygj2nd4 1472 34 2B 2B NNP cord-009571-mygj2nd4 1472 35 elution elution NNP cord-009571-mygj2nd4 1472 36 profile profile NN cord-009571-mygj2nd4 1472 37 after after IN cord-009571-mygj2nd4 1472 38 incubation incubation NN cord-009571-mygj2nd4 1472 39 with with IN cord-009571-mygj2nd4 1472 40 hyaluronic hyaluronic NN cord-009571-mygj2nd4 1472 41 acid acid NN cord-009571-mygj2nd4 1472 42 ( ( -LRB- cord-009571-mygj2nd4 1472 43 HA HA NNP cord-009571-mygj2nd4 1472 44 ) ) -RRB- cord-009571-mygj2nd4 1472 45 in in IN cord-009571-mygj2nd4 1472 46 vitro vitro FW cord-009571-mygj2nd4 1472 47 , , , cord-009571-mygj2nd4 1472 48 indicating indicate VBG cord-009571-mygj2nd4 1472 49 that that IN cord-009571-mygj2nd4 1472 50 PG PG NNP cord-009571-mygj2nd4 1472 51 - - HYPH cord-009571-mygj2nd4 1472 52 HA HA NNP cord-009571-mygj2nd4 1472 53 interaction interaction NN cord-009571-mygj2nd4 1472 54 had have VBD cord-009571-mygj2nd4 1472 55 not not RB cord-009571-mygj2nd4 1472 56 occurred occur VBN cord-009571-mygj2nd4 1472 57 . . . cord-009571-mygj2nd4 1473 1 However however RB cord-009571-mygj2nd4 1473 2 , , , cord-009571-mygj2nd4 1473 3 1 1 CD cord-009571-mygj2nd4 1473 4 week week NN cord-009571-mygj2nd4 1473 5 after after IN cord-009571-mygj2nd4 1473 6 removal removal NN cord-009571-mygj2nd4 1473 7 of of IN cord-009571-mygj2nd4 1473 8 the the DT cord-009571-mygj2nd4 1473 9 cast cast NN cord-009571-mygj2nd4 1473 10 , , , cord-009571-mygj2nd4 1473 11 aggregates aggregate NNS cord-009571-mygj2nd4 1473 12 had have VBD cord-009571-mygj2nd4 1473 13 again again RB cord-009571-mygj2nd4 1473 14 formed form VBN cord-009571-mygj2nd4 1473 15 in in IN cord-009571-mygj2nd4 1473 16 the the DT cord-009571-mygj2nd4 1473 17 cartilage cartilage NN cord-009571-mygj2nd4 1473 18 and and CC cord-009571-mygj2nd4 1473 19 were be VBD cord-009571-mygj2nd4 1473 20 as as RB cord-009571-mygj2nd4 1473 21 large large JJ cord-009571-mygj2nd4 1473 22 in in IN cord-009571-mygj2nd4 1473 23 hydrodynamic hydrodynamic JJ cord-009571-mygj2nd4 1473 24 size size NN cord-009571-mygj2nd4 1473 25 as as IN cord-009571-mygj2nd4 1473 26 those those DT cord-009571-mygj2nd4 1473 27 in in IN cord-009571-mygj2nd4 1473 28 control control NN cord-009571-mygj2nd4 1473 29 cartilage cartilage NN cord-009571-mygj2nd4 1473 30 . . . cord-009571-mygj2nd4 1474 1 These these DT cord-009571-mygj2nd4 1474 2 results result NNS cord-009571-mygj2nd4 1474 3 emphasize emphasize VBP cord-009571-mygj2nd4 1474 4 the the DT cord-009571-mygj2nd4 1474 5 importance importance NN cord-009571-mygj2nd4 1474 6 of of IN cord-009571-mygj2nd4 1474 7 joint joint JJ cord-009571-mygj2nd4 1474 8 motion motion NN cord-009571-mygj2nd4 1474 9 in in IN cord-009571-mygj2nd4 1474 10 maintenance maintenance NN cord-009571-mygj2nd4 1474 11 of of IN cord-009571-mygj2nd4 1474 12 the the DT cord-009571-mygj2nd4 1474 13 normal normal JJ cord-009571-mygj2nd4 1474 14 organization organization NN cord-009571-mygj2nd4 1474 15 of of IN cord-009571-mygj2nd4 1474 16 cartilage cartilage NN cord-009571-mygj2nd4 1474 17 PGs pg NNS cord-009571-mygj2nd4 1474 18 . . . cord-009571-mygj2nd4 1475 1 The the DT cord-009571-mygj2nd4 1475 2 PG PG NNP cord-009571-mygj2nd4 1475 3 aggregation aggregation NN cord-009571-mygj2nd4 1475 4 defect defect NN cord-009571-mygj2nd4 1475 5 which which WDT cord-009571-mygj2nd4 1475 6 occurs occur VBZ cord-009571-mygj2nd4 1475 7 with with IN cord-009571-mygj2nd4 1475 8 immobilization immobilization NN cord-009571-mygj2nd4 1475 9 alters alter VBZ cord-009571-mygj2nd4 1475 10 hydraulics hydraulic NNS cord-009571-mygj2nd4 1475 11 of of IN cord-009571-mygj2nd4 1475 12 the the DT cord-009571-mygj2nd4 1475 13 cartilage cartilage NN cord-009571-mygj2nd4 1475 14 , , , cord-009571-mygj2nd4 1475 15 especially especially RB cord-009571-mygj2nd4 1475 16 with with IN cord-009571-mygj2nd4 1475 17 impact impact NN cord-009571-mygj2nd4 1475 18 loading loading NN cord-009571-mygj2nd4 1475 19 , , , cord-009571-mygj2nd4 1475 20 and and CC cord-009571-mygj2nd4 1475 21 may may MD cord-009571-mygj2nd4 1475 22 thus thus RB cord-009571-mygj2nd4 1475 23 predispose predispose VB cord-009571-mygj2nd4 1475 24 to to TO cord-009571-mygj2nd4 1475 25 chondrocyte chondrocyte VB cord-009571-mygj2nd4 1475 26 injury injury NN cord-009571-mygj2nd4 1475 27 . . . cord-009571-mygj2nd4 1476 1 In in IN cord-009571-mygj2nd4 1476 2 the the DT cord-009571-mygj2nd4 1476 3 course course NN cord-009571-mygj2nd4 1476 4 of of IN cord-009571-mygj2nd4 1476 5 examining examine VBG cord-009571-mygj2nd4 1476 6 host host NN cord-009571-mygj2nd4 1476 7 defenses defense NNS cord-009571-mygj2nd4 1476 8 against against IN cord-009571-mygj2nd4 1476 9 infection infection NN cord-009571-mygj2nd4 1476 10 in in IN cord-009571-mygj2nd4 1476 11 patients patient NNS cord-009571-mygj2nd4 1476 12 with with IN cord-009571-mygj2nd4 1476 13 systemic systemic JJ cord-009571-mygj2nd4 1476 14 lupus lupus NN cord-009571-mygj2nd4 1476 15 erythematosus erythematosus NN cord-009571-mygj2nd4 1476 16 ( ( -LRB- cord-009571-mygj2nd4 1476 17 SLE SLE NNP cord-009571-mygj2nd4 1476 18 ) ) -RRB- cord-009571-mygj2nd4 1476 19 , , , cord-009571-mygj2nd4 1476 20 we -PRON- PRP cord-009571-mygj2nd4 1476 21 have have VBP cord-009571-mygj2nd4 1476 22 found find VBN cord-009571-mygj2nd4 1476 23 a a DT cord-009571-mygj2nd4 1476 24 previously previously RB cord-009571-mygj2nd4 1476 25 undescribed undescribed JJ cord-009571-mygj2nd4 1476 26 serum serum NN cord-009571-mygj2nd4 1476 27 inhibitor inhibitor NN cord-009571-mygj2nd4 1476 28 of of IN cord-009571-mygj2nd4 1476 29 complement complement NN cord-009571-mygj2nd4 1476 30 ( ( -LRB- cord-009571-mygj2nd4 1476 31 C5)-derived c5)-derived JJ cord-009571-mygj2nd4 1476 32 -chemotactic -chemotactic JJ cord-009571-mygj2nd4 1476 33 activity activity NN cord-009571-mygj2nd4 1476 34 ( ( -LRB- cord-009571-mygj2nd4 1476 35 CTxA CTxA NNP cord-009571-mygj2nd4 1476 36 ) ) -RRB- cord-009571-mygj2nd4 1476 37 . . . cord-009571-mygj2nd4 1477 1 Serum serum NN cord-009571-mygj2nd4 1477 2 from from IN cord-009571-mygj2nd4 1477 3 6 6 CD cord-009571-mygj2nd4 1477 4 of of IN cord-009571-mygj2nd4 1477 5 23 23 CD cord-009571-mygj2nd4 1477 6 patients patient NNS cord-009571-mygj2nd4 1477 7 , , , cord-009571-mygj2nd4 1477 8 when when WRB cord-009571-mygj2nd4 1477 9 activated activate VBN cord-009571-mygj2nd4 1477 10 with with IN cord-009571-mygj2nd4 1477 11 zymosan zymosan NNP cord-009571-mygj2nd4 1477 12 , , , cord-009571-mygj2nd4 1477 13 failed fail VBD cord-009571-mygj2nd4 1477 14 to to TO cord-009571-mygj2nd4 1477 15 attract attract VB cord-009571-mygj2nd4 1477 16 polymorphonuclear polymorphonuclear JJ cord-009571-mygj2nd4 1477 17 leukocytes leukocyte NNS cord-009571-mygj2nd4 1477 18 ( ( -LRB- cord-009571-mygj2nd4 1477 19 PMN PMN NNP cord-009571-mygj2nd4 1477 20 ) ) -RRB- cord-009571-mygj2nd4 1477 21 comparably comparably RB cord-009571-mygj2nd4 1477 22 to to IN cord-009571-mygj2nd4 1477 23 normal normal JJ cord-009571-mygj2nd4 1477 24 zymosan zymosan NNP cord-009571-mygj2nd4 1477 25 - - HYPH cord-009571-mygj2nd4 1477 26 treated treat VBN cord-009571-mygj2nd4 1477 27 serum serum NN cord-009571-mygj2nd4 1477 28 ( ( -LRB- cord-009571-mygj2nd4 1477 29 ZTS ZTS NNP cord-009571-mygj2nd4 1477 30 ) ) -RRB- cord-009571-mygj2nd4 1477 31 ( ( -LRB- cord-009571-mygj2nd4 1477 32 measured measure VBN cord-009571-mygj2nd4 1477 33 by by IN cord-009571-mygj2nd4 1477 34 the the DT cord-009571-mygj2nd4 1477 35 " " `` cord-009571-mygj2nd4 1477 36 leading leading JJ cord-009571-mygj2nd4 1477 37 front front NN cord-009571-mygj2nd4 1477 38 " " '' cord-009571-mygj2nd4 1477 39 method method NN cord-009571-mygj2nd4 1477 40 of of IN cord-009571-mygj2nd4 1477 41 Zigmond Zigmond NNP cord-009571-mygj2nd4 1477 42 and and CC cord-009571-mygj2nd4 1477 43 Hirsch Hirsch NNP cord-009571-mygj2nd4 1477 44 ) ) -RRB- cord-009571-mygj2nd4 1477 45 . . . cord-009571-mygj2nd4 1478 1 Incubation incubation NN cord-009571-mygj2nd4 1478 2 of of IN cord-009571-mygj2nd4 1478 3 normal normal JJ cord-009571-mygj2nd4 1478 4 PMN PMN NNP cord-009571-mygj2nd4 1478 5 with with IN cord-009571-mygj2nd4 1478 6 these these DT cord-009571-mygj2nd4 1478 7 sera sera NNP cord-009571-mygj2nd4 1478 8 did do VBD cord-009571-mygj2nd4 1478 9 not not RB cord-009571-mygj2nd4 1478 10 affect affect VB cord-009571-mygj2nd4 1478 11 their -PRON- PRP$ cord-009571-mygj2nd4 1478 12 random random JJ cord-009571-mygj2nd4 1478 13 motility motility NN cord-009571-mygj2nd4 1478 14 or or CC cord-009571-mygj2nd4 1478 15 subsequent subsequent JJ cord-009571-mygj2nd4 1478 16 chemotactic chemotactic JJ cord-009571-mygj2nd4 1478 17 response response NN cord-009571-mygj2nd4 1478 18 to to IN cord-009571-mygj2nd4 1478 19 normal normal JJ cord-009571-mygj2nd4 1478 20 ZTS zts NN cord-009571-mygj2nd4 1478 21 . . . cord-009571-mygj2nd4 1479 1 Whereas whereas IN cord-009571-mygj2nd4 1479 2 levels level NNS cord-009571-mygj2nd4 1479 3 of of IN cord-009571-mygj2nd4 1479 4 C3 c3 NN cord-009571-mygj2nd4 1479 5 and and CC cord-009571-mygj2nd4 1479 6 C4 C4 NNP cord-009571-mygj2nd4 1479 7 ( ( -LRB- cord-009571-mygj2nd4 1479 8 measured measure VBN cord-009571-mygj2nd4 1479 9 immunochemically immunochemically RB cord-009571-mygj2nd4 1479 10 ) ) -RRB- cord-009571-mygj2nd4 1479 11 were be VBD cord-009571-mygj2nd4 1479 12 modestly modestly RB cord-009571-mygj2nd4 1479 13 low low JJ cord-009571-mygj2nd4 1479 14 in in IN cord-009571-mygj2nd4 1479 15 these these DT cord-009571-mygj2nd4 1479 16 sera sera NNP cord-009571-mygj2nd4 1479 17 , , , cord-009571-mygj2nd4 1479 18 no no DT cord-009571-mygj2nd4 1479 19 gross gross JJ cord-009571-mygj2nd4 1479 20 abnormalities abnormality NNS cord-009571-mygj2nd4 1479 21 involving involve VBG cord-009571-mygj2nd4 1479 22 alternative alternative JJ cord-009571-mygj2nd4 1479 23 complement complement NN cord-009571-mygj2nd4 1479 24 pathway pathway NN cord-009571-mygj2nd4 1479 25 activation activation NN cord-009571-mygj2nd4 1479 26 could could MD cord-009571-mygj2nd4 1479 27 be be VB cord-009571-mygj2nd4 1479 28 detected detect VBN cord-009571-mygj2nd4 1479 29 . . . cord-009571-mygj2nd4 1480 1 When when WRB cord-009571-mygj2nd4 1480 2 preincubated preincubate VBN cord-009571-mygj2nd4 1480 3 with with IN cord-009571-mygj2nd4 1480 4 normal normal JJ cord-009571-mygj2nd4 1480 5 ZTS ZTS NNP cord-009571-mygj2nd4 1480 6 ( ( -LRB- cord-009571-mygj2nd4 1480 7 1 1 CD cord-009571-mygj2nd4 1480 8 : : SYM cord-009571-mygj2nd4 1480 9 1 1 CD cord-009571-mygj2nd4 1480 10 ) ) -RRB- cord-009571-mygj2nd4 1480 11 at at IN cord-009571-mygj2nd4 1480 12 37 37 CD cord-009571-mygj2nd4 1480 13 " " `` cord-009571-mygj2nd4 1480 14 for for IN cord-009571-mygj2nd4 1480 15 30 30 CD cord-009571-mygj2nd4 1480 16 minutes minute NNS cord-009571-mygj2nd4 1480 17 , , , cord-009571-mygj2nd4 1480 18 these these DT cord-009571-mygj2nd4 1480 19 sera sera NNP cord-009571-mygj2nd4 1480 20 caused cause VBD cord-009571-mygj2nd4 1480 21 significant significant JJ cord-009571-mygj2nd4 1480 22 inhibition inhibition NN cord-009571-mygj2nd4 1480 23 ( ( -LRB- cord-009571-mygj2nd4 1480 24 30 30 CD cord-009571-mygj2nd4 1480 25 - - SYM cord-009571-mygj2nd4 1480 26 1ooo 1ooo CD cord-009571-mygj2nd4 1480 27 / / SYM cord-009571-mygj2nd4 1480 28 o o NN cord-009571-mygj2nd4 1480 29 ) ) -RRB- cord-009571-mygj2nd4 1480 30 of of IN cord-009571-mygj2nd4 1480 31 CTxA. ctxa. CD cord-009571-mygj2nd4 1481 1 They -PRON- PRP cord-009571-mygj2nd4 1481 2 also also RB cord-009571-mygj2nd4 1481 3 inhibited inhibit VBD cord-009571-mygj2nd4 1481 4 the the DT cord-009571-mygj2nd4 1481 5 CTxA CTxA NNPS cord-009571-mygj2nd4 1481 6 of of IN cord-009571-mygj2nd4 1481 7 columnpurified columnpurified NNP cord-009571-mygj2nd4 1481 8 C5-derived c5-derive VBN cord-009571-mygj2nd4 1481 9 peptides peptide NNS cord-009571-mygj2nd4 1481 10 ( ( -LRB- cord-009571-mygj2nd4 1481 11 from from IN cord-009571-mygj2nd4 1481 12 normal normal JJ cord-009571-mygj2nd4 1481 13 ZTS ZTS NNP cord-009571-mygj2nd4 1481 14 ) ) -RRB- cord-009571-mygj2nd4 1481 15 , , , cord-009571-mygj2nd4 1481 16 but but CC cord-009571-mygj2nd4 1481 17 had have VBD cord-009571-mygj2nd4 1481 18 no no DT cord-009571-mygj2nd4 1481 19 effect effect NN cord-009571-mygj2nd4 1481 20 on on IN cord-009571-mygj2nd4 1481 21 the the DT cord-009571-mygj2nd4 1481 22 CTxA CTxA NNS cord-009571-mygj2nd4 1481 23 of of IN cord-009571-mygj2nd4 1481 24 either either CC cord-009571-mygj2nd4 1481 25 the the DT cord-009571-mygj2nd4 1481 26 synthetic synthetic JJ cord-009571-mygj2nd4 1481 27 peptide peptide NN cord-009571-mygj2nd4 1481 28 , , , cord-009571-mygj2nd4 1481 29 N n CD cord-009571-mygj2nd4 1481 30 - - HYPH cord-009571-mygj2nd4 1481 31 formylmet formylmet NNP cord-009571-mygj2nd4 1481 32 - - HYPH cord-009571-mygj2nd4 1481 33 leu leu NN cord-009571-mygj2nd4 1481 34 - - HYPH cord-009571-mygj2nd4 1481 35 phe phe NNP cord-009571-mygj2nd4 1481 36 or or CC cord-009571-mygj2nd4 1481 37 the the DT cord-009571-mygj2nd4 1481 38 bacterial bacterial JJ cord-009571-mygj2nd4 1481 39 chemotactic chemotactic JJ cord-009571-mygj2nd4 1481 40 factor factor NN cord-009571-mygj2nd4 1481 41 from from IN cord-009571-mygj2nd4 1481 42 E e NN cord-009571-mygj2nd4 1481 43 coli coli NNS cord-009571-mygj2nd4 1481 44 . . . cord-009571-mygj2nd4 1482 1 The the DT cord-009571-mygj2nd4 1482 2 inhibitor inhibitor NN cord-009571-mygj2nd4 1482 3 in in IN cord-009571-mygj2nd4 1482 4 these these DT cord-009571-mygj2nd4 1482 5 patients patient NNS cord-009571-mygj2nd4 1482 6 ' ' POS cord-009571-mygj2nd4 1482 7 serum serum NN cord-009571-mygj2nd4 1482 8 was be VBD cord-009571-mygj2nd4 1482 9 heat heat NN cord-009571-mygj2nd4 1482 10 - - HYPH cord-009571-mygj2nd4 1482 11 stable stable JJ cord-009571-mygj2nd4 1482 12 ( ( -LRB- cord-009571-mygj2nd4 1482 13 56 56 CD cord-009571-mygj2nd4 1482 14 ° ° NN cord-009571-mygj2nd4 1482 15 C c NN cord-009571-mygj2nd4 1482 16 for for IN cord-009571-mygj2nd4 1482 17 30 30 CD cord-009571-mygj2nd4 1482 18 minutes minute NNS cord-009571-mygj2nd4 1482 19 ) ) -RRB- cord-009571-mygj2nd4 1482 20 and and CC cord-009571-mygj2nd4 1482 21 acted act VBD cord-009571-mygj2nd4 1482 22 specifically specifically RB cord-009571-mygj2nd4 1482 23 on on IN cord-009571-mygj2nd4 1482 24 C5-derived c5-derived PRP$ cord-009571-mygj2nd4 1482 25 CTxA CTxA NNPS cord-009571-mygj2nd4 1482 26 ( ( -LRB- cord-009571-mygj2nd4 1482 27 not not RB cord-009571-mygj2nd4 1482 28 on on IN cord-009571-mygj2nd4 1482 29 PMN PMN NNP cord-009571-mygj2nd4 1482 30 ) ) -RRB- cord-009571-mygj2nd4 1482 31 . . . cord-009571-mygj2nd4 1483 1 Mixing mix VBG cord-009571-mygj2nd4 1483 2 ( ( -LRB- cord-009571-mygj2nd4 1483 3 without without IN cord-009571-mygj2nd4 1483 4 preincubation preincubation NN cord-009571-mygj2nd4 1483 5 ) ) -RRB- cord-009571-mygj2nd4 1483 6 of of IN cord-009571-mygj2nd4 1483 7 patient patient JJ cord-009571-mygj2nd4 1483 8 serum serum NN cord-009571-mygj2nd4 1483 9 with with IN cord-009571-mygj2nd4 1483 10 normal normal JJ cord-009571-mygj2nd4 1483 11 ZTS ZTS NNP cord-009571-mygj2nd4 1483 12 failed fail VBD cord-009571-mygj2nd4 1483 13 to to TO cord-009571-mygj2nd4 1483 14 cause cause VB cord-009571-mygj2nd4 1483 15 inhibition inhibition NN cord-009571-mygj2nd4 1483 16 of of IN cord-009571-mygj2nd4 1483 17 CTxA. CTxA. NNS cord-009571-mygj2nd4 1484 1 The the DT cord-009571-mygj2nd4 1484 2 inhibitor inhibitor NN cord-009571-mygj2nd4 1484 3 also also RB cord-009571-mygj2nd4 1484 4 acted act VBD cord-009571-mygj2nd4 1484 5 reversibly reversibly RB cord-009571-mygj2nd4 1484 6 ; ; : cord-009571-mygj2nd4 1484 7 molecular molecular JJ cord-009571-mygj2nd4 1484 8 sieve sieve NN cord-009571-mygj2nd4 1484 9 chromatography chromatography NN cord-009571-mygj2nd4 1484 10 dissociated dissociate VBN cord-009571-mygj2nd4 1484 11 heat heat NN cord-009571-mygj2nd4 1484 12 - - HYPH cord-009571-mygj2nd4 1484 13 stable stable JJ cord-009571-mygj2nd4 1484 14 inhibitory inhibitory JJ cord-009571-mygj2nd4 1484 15 activity activity NN cord-009571-mygj2nd4 1484 16 ( ( -LRB- cord-009571-mygj2nd4 1484 17 a a DT cord-009571-mygj2nd4 1484 18 single single JJ cord-009571-mygj2nd4 1484 19 peak peak NN cord-009571-mygj2nd4 1484 20 with with IN cord-009571-mygj2nd4 1484 21 an an DT cord-009571-mygj2nd4 1484 22 apparent apparent JJ cord-009571-mygj2nd4 1484 23 molecular molecular JJ cord-009571-mygj2nd4 1484 24 weight weight NN cord-009571-mygj2nd4 1484 25 of of IN cord-009571-mygj2nd4 1484 26 50 50 CD cord-009571-mygj2nd4 1484 27 - - SYM cord-009571-mygj2nd4 1484 28 60,000 60,000 CD cord-009571-mygj2nd4 1484 29 daltons dalton NNS cord-009571-mygj2nd4 1484 30 ) ) -RRB- cord-009571-mygj2nd4 1484 31 from from IN cord-009571-mygj2nd4 1484 32 normal normal JJ cord-009571-mygj2nd4 1484 33 amounts amount NNS cord-009571-mygj2nd4 1484 34 of of IN cord-009571-mygj2nd4 1484 35 C5-derived C5-derived NNS cord-009571-mygj2nd4 1484 36 CTxA CTxA NNPS cord-009571-mygj2nd4 1484 37 in in IN cord-009571-mygj2nd4 1484 38 patients patient NNS cord-009571-mygj2nd4 1484 39 ZTS ZTS NNP cord-009571-mygj2nd4 1484 40 and and CC cord-009571-mygj2nd4 1484 41 in in IN cord-009571-mygj2nd4 1484 42 mixtures mixture NNS cord-009571-mygj2nd4 1484 43 of of IN cord-009571-mygj2nd4 1484 44 normal normal JJ cord-009571-mygj2nd4 1484 45 ZTS zts NN cord-009571-mygj2nd4 1484 46 incubated incubate VBN cord-009571-mygj2nd4 1484 47 with with IN cord-009571-mygj2nd4 1484 48 patient patient JJ cord-009571-mygj2nd4 1484 49 serum serum NN cord-009571-mygj2nd4 1484 50 . . . cord-009571-mygj2nd4 1485 1 Further further JJ cord-009571-mygj2nd4 1485 2 characterization characterization NN cord-009571-mygj2nd4 1485 3 of of IN cord-009571-mygj2nd4 1485 4 the the DT cord-009571-mygj2nd4 1485 5 inhibitor inhibitor NN cord-009571-mygj2nd4 1485 6 has have VBZ cord-009571-mygj2nd4 1485 7 revealed reveal VBN cord-009571-mygj2nd4 1485 8 it -PRON- PRP cord-009571-mygj2nd4 1485 9 to to TO cord-009571-mygj2nd4 1485 10 be be VB cord-009571-mygj2nd4 1485 11 a a DT cord-009571-mygj2nd4 1485 12 basic basic JJ cord-009571-mygj2nd4 1485 13 protein protein NN cord-009571-mygj2nd4 1485 14 ( ( -LRB- cord-009571-mygj2nd4 1485 15 PI pi NN cord-009571-mygj2nd4 1485 16 between between IN cord-009571-mygj2nd4 1485 17 9 9 CD cord-009571-mygj2nd4 1485 18 and and CC cord-009571-mygj2nd4 1485 19 10 10 CD cord-009571-mygj2nd4 1485 20 ) ) -RRB- cord-009571-mygj2nd4 1485 21 which which WDT cord-009571-mygj2nd4 1485 22 can can MD cord-009571-mygj2nd4 1485 23 be be VB cord-009571-mygj2nd4 1485 24 inactivated inactivate VBN cord-009571-mygj2nd4 1485 25 completely completely RB cord-009571-mygj2nd4 1485 26 by by IN cord-009571-mygj2nd4 1485 27 treatment treatment NN cord-009571-mygj2nd4 1485 28 with with IN cord-009571-mygj2nd4 1485 29 pronase pronase NNP cord-009571-mygj2nd4 1485 30 . . . cord-009571-mygj2nd4 1486 1 Despite despite IN cord-009571-mygj2nd4 1486 2 its -PRON- PRP$ cord-009571-mygj2nd4 1486 3 effect effect NN cord-009571-mygj2nd4 1486 4 on on IN cord-009571-mygj2nd4 1486 5 C5derived C5derived NNP cord-009571-mygj2nd4 1486 6 CTxA CTxA NNPS cord-009571-mygj2nd4 1486 7 , , , cord-009571-mygj2nd4 1486 8 the the DT cord-009571-mygj2nd4 1486 9 inhibitor inhibitor NN cord-009571-mygj2nd4 1486 10 did do VBD cord-009571-mygj2nd4 1486 11 not not RB cord-009571-mygj2nd4 1486 12 influence influence VB cord-009571-mygj2nd4 1486 13 two two CD cord-009571-mygj2nd4 1486 14 other other JJ cord-009571-mygj2nd4 1486 15 C5derived c5derived JJ cord-009571-mygj2nd4 1486 16 biologic biologic JJ cord-009571-mygj2nd4 1486 17 activities activity NNS cord-009571-mygj2nd4 1486 18 in in IN cord-009571-mygj2nd4 1486 19 ZTS zts NN cord-009571-mygj2nd4 1486 20 : : : cord-009571-mygj2nd4 1487 1 PMN pmn NN cord-009571-mygj2nd4 1487 2 lysosomal lysosomal JJ cord-009571-mygj2nd4 1487 3 enzyme enzyme NN cord-009571-mygj2nd4 1487 4 releasing release VBG cord-009571-mygj2nd4 1487 5 activity activity NN cord-009571-mygj2nd4 1487 6 and and CC cord-009571-mygj2nd4 1487 7 PMN PMN NNP cord-009571-mygj2nd4 1487 8 aggregating aggregate VBG cord-009571-mygj2nd4 1487 9 activity activity NN cord-009571-mygj2nd4 1487 10 . . . cord-009571-mygj2nd4 1488 1 This this DT cord-009571-mygj2nd4 1488 2 heatstable heatstable JJ cord-009571-mygj2nd4 1488 3 inhibitor inhibitor NN cord-009571-mygj2nd4 1488 4 , , , cord-009571-mygj2nd4 1488 5 uniquely uniquely RB cord-009571-mygj2nd4 1488 6 specific specific JJ cord-009571-mygj2nd4 1488 7 for for IN cord-009571-mygj2nd4 1488 8 C5-derived c5-derived PRP$ cord-009571-mygj2nd4 1488 9 CTxA CTxA NNPS cord-009571-mygj2nd4 1488 10 in in IN cord-009571-mygj2nd4 1488 11 serum serum NN cord-009571-mygj2nd4 1488 12 from from IN cord-009571-mygj2nd4 1488 13 some some DT cord-009571-mygj2nd4 1488 14 patients patient NNS cord-009571-mygj2nd4 1488 15 with with IN cord-009571-mygj2nd4 1488 16 active active JJ cord-009571-mygj2nd4 1488 17 SLE SLE NNP cord-009571-mygj2nd4 1488 18 , , , cord-009571-mygj2nd4 1488 19 may may MD cord-009571-mygj2nd4 1488 20 account account VB cord-009571-mygj2nd4 1488 21 , , , cord-009571-mygj2nd4 1488 22 in in IN cord-009571-mygj2nd4 1488 23 part part NN cord-009571-mygj2nd4 1488 24 , , , cord-009571-mygj2nd4 1488 25 for for IN cord-009571-mygj2nd4 1488 26 increased increase VBN cord-009571-mygj2nd4 1488 27 susceptibility susceptibility NN cord-009571-mygj2nd4 1488 28 to to IN cord-009571-mygj2nd4 1488 29 infections infection NNS cord-009571-mygj2nd4 1488 30 caused cause VBN cord-009571-mygj2nd4 1488 31 by by IN cord-009571-mygj2nd4 1488 32 pyogenic pyogenic JJ cord-009571-mygj2nd4 1488 33 microorganisms microorganism NNS cord-009571-mygj2nd4 1488 34 . . . cord-009571-mygj2nd4 1489 1 The the DT cord-009571-mygj2nd4 1489 2 evidence evidence NN cord-009571-mygj2nd4 1489 3 that that DT cord-009571-mygj2nd4 1489 4 type type NN cord-009571-mygj2nd4 1489 5 C c NN cord-009571-mygj2nd4 1489 6 viruses virus NNS cord-009571-mygj2nd4 1489 7 are be VBP cord-009571-mygj2nd4 1489 8 involved involve VBN cord-009571-mygj2nd4 1489 9 in in IN cord-009571-mygj2nd4 1489 10 systemic systemic JJ cord-009571-mygj2nd4 1489 11 lupus lupus NN cord-009571-mygj2nd4 1489 12 erythematosus erythematosus NN cord-009571-mygj2nd4 1489 13 ( ( -LRB- cord-009571-mygj2nd4 1489 14 SLE SLE NNP cord-009571-mygj2nd4 1489 15 ) ) -RRB- cord-009571-mygj2nd4 1489 16 is be VBZ cord-009571-mygj2nd4 1489 17 conflicting conflict VBG cord-009571-mygj2nd4 1489 18 . . . cord-009571-mygj2nd4 1490 1 We -PRON- PRP cord-009571-mygj2nd4 1490 2 tried try VBD cord-009571-mygj2nd4 1490 3 to to TO cord-009571-mygj2nd4 1490 4 detect detect VB cord-009571-mygj2nd4 1490 5 type type NN cord-009571-mygj2nd4 1490 6 C c NN cord-009571-mygj2nd4 1490 7 expression expression NN cord-009571-mygj2nd4 1490 8 in in IN cord-009571-mygj2nd4 1490 9 a a DT cord-009571-mygj2nd4 1490 10 total total NN cord-009571-mygj2nd4 1490 11 of of IN cord-009571-mygj2nd4 1490 12 34 34 CD cord-009571-mygj2nd4 1490 13 SLE SLE NNP cord-009571-mygj2nd4 1490 14 patients patient NNS cord-009571-mygj2nd4 1490 15 during during IN cord-009571-mygj2nd4 1490 16 various various JJ cord-009571-mygj2nd4 1490 17 collaborative collaborative JJ cord-009571-mygj2nd4 1490 18 studies study NNS cord-009571-mygj2nd4 1490 19 over over IN cord-009571-mygj2nd4 1490 20 the the DT cord-009571-mygj2nd4 1490 21 past past JJ cord-009571-mygj2nd4 1490 22 four four CD cord-009571-mygj2nd4 1490 23 years year NNS cord-009571-mygj2nd4 1490 24 . . . cord-009571-mygj2nd4 1491 1 Forty forty CD cord-009571-mygj2nd4 1491 2 tissues tissue NNS cord-009571-mygj2nd4 1491 3 ( ( -LRB- cord-009571-mygj2nd4 1491 4 17 17 CD cord-009571-mygj2nd4 1491 5 placenta placenta NN cord-009571-mygj2nd4 1491 6 or or CC cord-009571-mygj2nd4 1491 7 gestational gestational JJ cord-009571-mygj2nd4 1491 8 products product NNS cord-009571-mygj2nd4 1491 9 , , , cord-009571-mygj2nd4 1491 10 10 10 CD cord-009571-mygj2nd4 1491 11 spleen spleen NNS cord-009571-mygj2nd4 1491 12 , , , cord-009571-mygj2nd4 1491 13 6 6 CD cord-009571-mygj2nd4 1491 14 kidney kidney NN cord-009571-mygj2nd4 1491 15 , , . cord-009571-mygj2nd4 1492 1 7 7 CD cord-009571-mygj2nd4 1492 2 other other JJ cord-009571-mygj2nd4 1492 3 ) ) -RRB- cord-009571-mygj2nd4 1493 1 and/or and/or CC cord-009571-mygj2nd4 1493 2 cell cell NN cord-009571-mygj2nd4 1493 3 cultures culture NNS cord-009571-mygj2nd4 1493 4 derived derive VBN cord-009571-mygj2nd4 1493 5 from from IN cord-009571-mygj2nd4 1493 6 them -PRON- PRP cord-009571-mygj2nd4 1493 7 were be VBD cord-009571-mygj2nd4 1493 8 tested test VBN cord-009571-mygj2nd4 1493 9 a a DT cord-009571-mygj2nd4 1493 10 total total NN cord-009571-mygj2nd4 1493 11 of of IN cord-009571-mygj2nd4 1493 12 110 110 CD cord-009571-mygj2nd4 1493 13 times time NNS cord-009571-mygj2nd4 1493 14 using use VBG cord-009571-mygj2nd4 1493 15 10 10 CD cord-009571-mygj2nd4 1493 16 different different JJ cord-009571-mygj2nd4 1493 17 methods method NNS cord-009571-mygj2nd4 1493 18 . . . cord-009571-mygj2nd4 1494 1 Seventyfive seventyfive JJ cord-009571-mygj2nd4 1494 2 percent percent NN cord-009571-mygj2nd4 1494 3 of of IN cord-009571-mygj2nd4 1494 4 the the DT cord-009571-mygj2nd4 1494 5 tissues tissue NNS cord-009571-mygj2nd4 1494 6 were be VBD cord-009571-mygj2nd4 1494 7 tested test VBN cord-009571-mygj2nd4 1494 8 by by IN cord-009571-mygj2nd4 1494 9 2 2 CD cord-009571-mygj2nd4 1494 10 or or CC cord-009571-mygj2nd4 1494 11 more more JJR cord-009571-mygj2nd4 1494 12 methods method NNS cord-009571-mygj2nd4 1494 13 and and CC cord-009571-mygj2nd4 1494 14 33 33 CD cord-009571-mygj2nd4 1494 15 % % NN cord-009571-mygj2nd4 1494 16 by by IN cord-009571-mygj2nd4 1494 17 4 4 CD cord-009571-mygj2nd4 1494 18 or or CC cord-009571-mygj2nd4 1494 19 more more JJR cord-009571-mygj2nd4 1494 20 . . . cord-009571-mygj2nd4 1495 1 Type type NN cord-009571-mygj2nd4 1495 2 C C NNP cord-009571-mygj2nd4 1495 3 virus virus NN cord-009571-mygj2nd4 1495 4 isolation isolation NN cord-009571-mygj2nd4 1495 5 was be VBD cord-009571-mygj2nd4 1495 6 attempted attempt VBN cord-009571-mygj2nd4 1495 7 using use VBG cord-009571-mygj2nd4 1495 8 four four CD cord-009571-mygj2nd4 1495 9 distinct distinct JJ cord-009571-mygj2nd4 1495 10 protocols protocol NNS cord-009571-mygj2nd4 1495 11 : : : cord-009571-mygj2nd4 1495 12 culture culture NN cord-009571-mygj2nd4 1495 13 with with IN cord-009571-mygj2nd4 1495 14 sedimentation sedimentation NN cord-009571-mygj2nd4 1495 15 of of IN cord-009571-mygj2nd4 1495 16 SH sh NN cord-009571-mygj2nd4 1495 17 - - HYPH cord-009571-mygj2nd4 1495 18 uridine uridine NN cord-009571-mygj2nd4 1495 19 - - HYPH cord-009571-mygj2nd4 1495 20 labeled label VBN cord-009571-mygj2nd4 1495 21 virions virion NNS cord-009571-mygj2nd4 1495 22 , , , cord-009571-mygj2nd4 1495 23 cocultivation cocultivation NN cord-009571-mygj2nd4 1495 24 with with IN cord-009571-mygj2nd4 1495 25 viral viral JJ cord-009571-mygj2nd4 1495 26 RNA RNA NNP cord-009571-mygj2nd4 1495 27 - - HYPH cord-009571-mygj2nd4 1495 28 dependent dependent JJ cord-009571-mygj2nd4 1495 29 D D NNP cord-009571-mygj2nd4 1495 30 N n NN cord-009571-mygj2nd4 1495 31 A a NN cord-009571-mygj2nd4 1495 32 polymerase polymerase NN cord-009571-mygj2nd4 1495 33 assay assay NN cord-009571-mygj2nd4 1495 34 , , , cord-009571-mygj2nd4 1495 35 cocultivation cocultivation NN cord-009571-mygj2nd4 1495 36 with with IN cord-009571-mygj2nd4 1495 37 focus focus NN cord-009571-mygj2nd4 1495 38 formation formation NN cord-009571-mygj2nd4 1495 39 assay assay NN cord-009571-mygj2nd4 1495 40 for for IN cord-009571-mygj2nd4 1495 41 helper helper NN cord-009571-mygj2nd4 1495 42 virus virus NN cord-009571-mygj2nd4 1495 43 rescue rescue NN cord-009571-mygj2nd4 1495 44 of of IN cord-009571-mygj2nd4 1495 45 the the DT cord-009571-mygj2nd4 1495 46 defective defective JJ cord-009571-mygj2nd4 1495 47 murine murine JJ cord-009571-mygj2nd4 1495 48 sarcoma sarcoma NN cord-009571-mygj2nd4 1495 49 virus virus NN cord-009571-mygj2nd4 1495 50 genome genome NN cord-009571-mygj2nd4 1495 51 ( ( -LRB- cord-009571-mygj2nd4 1495 52 A a DT cord-009571-mygj2nd4 1495 53 Albino Albino NNP cord-009571-mygj2nd4 1495 54 ) ) -RRB- cord-009571-mygj2nd4 1495 55 , , , cord-009571-mygj2nd4 1495 56 and and CC cord-009571-mygj2nd4 1495 57 triple triple JJ cord-009571-mygj2nd4 1495 58 cell cell NN cord-009571-mygj2nd4 1495 59 fusion fusion NN cord-009571-mygj2nd4 1495 60 with with IN cord-009571-mygj2nd4 1495 61 viral viral JJ cord-009571-mygj2nd4 1495 62 polymerase polymerase NN cord-009571-mygj2nd4 1495 63 assay assay NN cord-009571-mygj2nd4 1495 64 . . . cord-009571-mygj2nd4 1496 1 Thirty thirty CD cord-009571-mygj2nd4 1496 2 - - HYPH cord-009571-mygj2nd4 1496 3 four four CD cord-009571-mygj2nd4 1496 4 tissues tissue NNS cord-009571-mygj2nd4 1496 5 from from IN cord-009571-mygj2nd4 1496 6 3 3 CD cord-009571-mygj2nd4 1496 7 1 1 CD cord-009571-mygj2nd4 1496 8 patients patient NNS cord-009571-mygj2nd4 1496 9 were be VBD cord-009571-mygj2nd4 1496 10 tested test VBN cord-009571-mygj2nd4 1496 11 a a DT cord-009571-mygj2nd4 1496 12 total total NN cord-009571-mygj2nd4 1496 13 of of IN cord-009571-mygj2nd4 1496 14 55 55 CD cord-009571-mygj2nd4 1496 15 times time NNS cord-009571-mygj2nd4 1496 16 with with IN cord-009571-mygj2nd4 1496 17 negative negative JJ cord-009571-mygj2nd4 1496 18 results result NNS cord-009571-mygj2nd4 1496 19 except except IN cord-009571-mygj2nd4 1496 20 for for IN cord-009571-mygj2nd4 1496 21 one one CD cord-009571-mygj2nd4 1496 22 type type NN cord-009571-mygj2nd4 1496 23 C c NN cord-009571-mygj2nd4 1496 24 isolate isolate VBP cord-009571-mygj2nd4 1496 25 in in IN cord-009571-mygj2nd4 1496 26 a a DT cord-009571-mygj2nd4 1496 27 recent recent JJ cord-009571-mygj2nd4 1496 28 experiment experiment NN cord-009571-mygj2nd4 1496 29 . . . cord-009571-mygj2nd4 1497 1 Detection detection NN cord-009571-mygj2nd4 1497 2 of of IN cord-009571-mygj2nd4 1497 3 both both DT cord-009571-mygj2nd4 1497 4 type type NN cord-009571-mygj2nd4 1497 5 C c NN cord-009571-mygj2nd4 1497 6 interspecies interspecie NNS cord-009571-mygj2nd4 1497 7 and and CC cord-009571-mygj2nd4 1497 8 primate primate JJ cord-009571-mygj2nd4 1497 9 species species NN cord-009571-mygj2nd4 1497 10 antigens antigen NNS cord-009571-mygj2nd4 1497 11 was be VBD cord-009571-mygj2nd4 1497 12 attempted attempt VBN cord-009571-mygj2nd4 1497 13 using use VBG cord-009571-mygj2nd4 1497 14 3 3 CD cord-009571-mygj2nd4 1497 15 different different JJ cord-009571-mygj2nd4 1497 16 radioimmunoassays radioimmunoassay NNS cord-009571-mygj2nd4 1497 17 in in IN cord-009571-mygj2nd4 1497 18 2 2 CD cord-009571-mygj2nd4 1497 19 separate separate JJ cord-009571-mygj2nd4 1497 20 laboratories laboratory NNS cord-009571-mygj2nd4 1497 21 ( ( -LRB- cord-009571-mygj2nd4 1497 22 G. G. NNP cord-009571-mygj2nd4 1497 23 J. J. NNP cord-009571-mygj2nd4 1497 24 Todaro Todaro NNP cord-009571-mygj2nd4 1497 25 , , , cord-009571-mygj2nd4 1497 26 H. H. NNP cord-009571-mygj2nd4 1497 27 P. P. NNP cord-009571-mygj2nd4 1497 28 Charman Charman NNP cord-009571-mygj2nd4 1497 29 ) ) -RRB- cord-009571-mygj2nd4 1497 30 , , , cord-009571-mygj2nd4 1497 31 and and CC cord-009571-mygj2nd4 1497 32 indirect indirect JJ cord-009571-mygj2nd4 1497 33 immunofluorescence immunofluorescence NN cord-009571-mygj2nd4 1497 34 ( ( -LRB- cord-009571-mygj2nd4 1497 35 R. R. NNP cord-009571-mygj2nd4 1497 36 C. C. NNP cord-009571-mygj2nd4 1497 37 Mellors Mellors NNP cord-009571-mygj2nd4 1497 38 ) ) -RRB- cord-009571-mygj2nd4 1497 39 . . . cord-009571-mygj2nd4 1498 1 Twenty twenty CD cord-009571-mygj2nd4 1498 2 - - HYPH cord-009571-mygj2nd4 1498 3 two two CD cord-009571-mygj2nd4 1498 4 tissues tissue NNS cord-009571-mygj2nd4 1498 5 from from IN cord-009571-mygj2nd4 1498 6 18 18 CD cord-009571-mygj2nd4 1498 7 patients patient NNS cord-009571-mygj2nd4 1498 8 were be VBD cord-009571-mygj2nd4 1498 9 tested test VBN cord-009571-mygj2nd4 1498 10 a a DT cord-009571-mygj2nd4 1498 11 total total NN cord-009571-mygj2nd4 1498 12 of of IN cord-009571-mygj2nd4 1498 13 37 37 CD cord-009571-mygj2nd4 1498 14 times time NNS cord-009571-mygj2nd4 1498 15 with with IN cord-009571-mygj2nd4 1498 16 negative negative JJ cord-009571-mygj2nd4 1498 17 results result NNS cord-009571-mygj2nd4 1498 18 . . . cord-009571-mygj2nd4 1499 1 Electronmicroscopy electronmicroscopy NN cord-009571-mygj2nd4 1499 2 of of IN cord-009571-mygj2nd4 1499 3 gestational gestational JJ cord-009571-mygj2nd4 1499 4 products product NNS cord-009571-mygj2nd4 1499 5 from from IN cord-009571-mygj2nd4 1499 6 9 9 CD cord-009571-mygj2nd4 1499 7 patients patient NNS cord-009571-mygj2nd4 1499 8 revealed reveal VBD cord-009571-mygj2nd4 1499 9 type type NN cord-009571-mygj2nd4 1499 10 C c NN cord-009571-mygj2nd4 1499 11 - - HYPH cord-009571-mygj2nd4 1499 12 like like JJ cord-009571-mygj2nd4 1499 13 particles particle NNS cord-009571-mygj2nd4 1499 14 in in IN cord-009571-mygj2nd4 1499 15 4 4 CD cord-009571-mygj2nd4 1499 16 placentas placenta NNS cord-009571-mygj2nd4 1499 17 , , , cord-009571-mygj2nd4 1499 18 but but CC cord-009571-mygj2nd4 1499 19 also also RB cord-009571-mygj2nd4 1499 20 in in IN cord-009571-mygj2nd4 1499 21 2 2 CD cord-009571-mygj2nd4 1499 22 of of IN cord-009571-mygj2nd4 1499 23 3 3 CD cord-009571-mygj2nd4 1499 24 normal normal JJ cord-009571-mygj2nd4 1499 25 controls control NNS cord-009571-mygj2nd4 1499 26 ( ( -LRB- cord-009571-mygj2nd4 1499 27 M. M. NNP cord-009571-mygj2nd4 1499 28 Imamura Imamura NNP cord-009571-mygj2nd4 1499 29 ) ) -RRB- cord-009571-mygj2nd4 1499 30 . . . cord-009571-mygj2nd4 1500 1 Type type NN cord-009571-mygj2nd4 1500 2 C c NN cord-009571-mygj2nd4 1500 3 - - HYPH cord-009571-mygj2nd4 1500 4 related relate VBN cord-009571-mygj2nd4 1500 5 sequences sequence NNS cord-009571-mygj2nd4 1500 6 were be VBD cord-009571-mygj2nd4 1500 7 not not RB cord-009571-mygj2nd4 1500 8 found find VBN cord-009571-mygj2nd4 1500 9 in in IN cord-009571-mygj2nd4 1500 10 cellular cellular JJ cord-009571-mygj2nd4 1500 11 D d NN cord-009571-mygj2nd4 1500 12 N n NN cord-009571-mygj2nd4 1500 13 A a NN cord-009571-mygj2nd4 1500 14 from from IN cord-009571-mygj2nd4 1500 15 9 9 CD cord-009571-mygj2nd4 1500 16 patients patient NNS cord-009571-mygj2nd4 1500 17 using use VBG cord-009571-mygj2nd4 1500 18 hybridization hybridization NN cord-009571-mygj2nd4 1500 19 to to IN cord-009571-mygj2nd4 1500 20 a a DT cord-009571-mygj2nd4 1500 21 murine murine JJ cord-009571-mygj2nd4 1500 22 type type NN cord-009571-mygj2nd4 1500 23 C c NN cord-009571-mygj2nd4 1500 24 cDNA cdna NN cord-009571-mygj2nd4 1500 25 probe probe NN cord-009571-mygj2nd4 1500 26 ( ( -LRB- cord-009571-mygj2nd4 1500 27 G. G. NNP cord-009571-mygj2nd4 1500 28 s. s. NNP cord-009571-mygj2nd4 1500 29 Aulakh Aulakh NNP cord-009571-mygj2nd4 1500 30 ) ) -RRB- cord-009571-mygj2nd4 1500 31 . . . cord-009571-mygj2nd4 1501 1 Various various JJ cord-009571-mygj2nd4 1501 2 false false JJ cord-009571-mygj2nd4 1501 3 - - HYPH cord-009571-mygj2nd4 1501 4 positive positive JJ cord-009571-mygj2nd4 1501 5 results result NNS cord-009571-mygj2nd4 1501 6 were be VBD cord-009571-mygj2nd4 1501 7 also also RB cord-009571-mygj2nd4 1501 8 encountered encounter VBN cord-009571-mygj2nd4 1501 9 in in IN cord-009571-mygj2nd4 1501 10 most most JJS cord-009571-mygj2nd4 1501 11 of of IN cord-009571-mygj2nd4 1501 12 the the DT cord-009571-mygj2nd4 1501 13 studies study NNS cord-009571-mygj2nd4 1501 14 . . . cord-009571-mygj2nd4 1502 1 The the DT cord-009571-mygj2nd4 1502 2 virus virus NN cord-009571-mygj2nd4 1502 3 isolate isolate VB cord-009571-mygj2nd4 1502 4 - - HYPH cord-009571-mygj2nd4 1502 5 positive positive JJ cord-009571-mygj2nd4 1502 6 patient patient NN cord-009571-mygj2nd4 1502 7 has have VBZ cord-009571-mygj2nd4 1502 8 not not RB cord-009571-mygj2nd4 1502 9 yet yet RB cord-009571-mygj2nd4 1502 10 been be VBN cord-009571-mygj2nd4 1502 11 tested test VBN cord-009571-mygj2nd4 1502 12 by by IN cord-009571-mygj2nd4 1502 13 other other JJ cord-009571-mygj2nd4 1502 14 methods method NNS cord-009571-mygj2nd4 1502 15 , , , cord-009571-mygj2nd4 1502 16 but but CC cord-009571-mygj2nd4 1502 17 the the DT cord-009571-mygj2nd4 1502 18 4 4 CD cord-009571-mygj2nd4 1502 19 patients patient NNS cord-009571-mygj2nd4 1502 20 with with IN cord-009571-mygj2nd4 1502 21 type type NN cord-009571-mygj2nd4 1502 22 C c NN cord-009571-mygj2nd4 1502 23 - - HYPH cord-009571-mygj2nd4 1502 24 like like JJ cord-009571-mygj2nd4 1502 25 particles particle NNS cord-009571-mygj2nd4 1502 26 were be VBD cord-009571-mygj2nd4 1502 27 each each DT cord-009571-mygj2nd4 1502 28 tested test VBN cord-009571-mygj2nd4 1502 29 by by IN cord-009571-mygj2nd4 1502 30 3 3 CD cord-009571-mygj2nd4 1502 31 to to TO cord-009571-mygj2nd4 1502 32 5 5 CD cord-009571-mygj2nd4 1502 33 other other JJ cord-009571-mygj2nd4 1502 34 methods method NNS cord-009571-mygj2nd4 1502 35 with with IN cord-009571-mygj2nd4 1502 36 negative negative JJ cord-009571-mygj2nd4 1502 37 results result NNS cord-009571-mygj2nd4 1502 38 . . . cord-009571-mygj2nd4 1503 1 Thus thus RB cord-009571-mygj2nd4 1503 2 5 5 CD cord-009571-mygj2nd4 1503 3 of of IN cord-009571-mygj2nd4 1503 4 the the DT cord-009571-mygj2nd4 1503 5 total total JJ cord-009571-mygj2nd4 1503 6 110 110 CD cord-009571-mygj2nd4 1503 7 tests test NNS cord-009571-mygj2nd4 1503 8 were be VBD cord-009571-mygj2nd4 1503 9 positive positive JJ cord-009571-mygj2nd4 1503 10 on on IN cord-009571-mygj2nd4 1503 11 5 5 CD cord-009571-mygj2nd4 1503 12 of of IN cord-009571-mygj2nd4 1503 13 the the DT cord-009571-mygj2nd4 1503 14 40 40 CD cord-009571-mygj2nd4 1503 15 tissues tissue NNS cord-009571-mygj2nd4 1503 16 from from IN cord-009571-mygj2nd4 1503 17 34 34 CD cord-009571-mygj2nd4 1503 18 patients patient NNS cord-009571-mygj2nd4 1503 19 . . . cord-009571-mygj2nd4 1504 1 These these DT cord-009571-mygj2nd4 1504 2 combined combine VBN cord-009571-mygj2nd4 1504 3 collaborative collaborative JJ cord-009571-mygj2nd4 1504 4 studies study NNS cord-009571-mygj2nd4 1504 5 are be VBP cord-009571-mygj2nd4 1504 6 the the DT cord-009571-mygj2nd4 1504 7 most most RBS cord-009571-mygj2nd4 1504 8 comprehensive comprehensive JJ cord-009571-mygj2nd4 1504 9 yet yet RB cord-009571-mygj2nd4 1504 10 done do VBN cord-009571-mygj2nd4 1504 11 in in IN cord-009571-mygj2nd4 1504 12 SLE SLE NNP cord-009571-mygj2nd4 1504 13 . . . cord-009571-mygj2nd4 1505 1 If if IN cord-009571-mygj2nd4 1505 2 type type NN cord-009571-mygj2nd4 1505 3 C c NN cord-009571-mygj2nd4 1505 4 expression expression NN cord-009571-mygj2nd4 1505 5 is be VBZ cord-009571-mygj2nd4 1505 6 enhanced enhance VBN cord-009571-mygj2nd4 1505 7 in in IN cord-009571-mygj2nd4 1505 8 SLE SLE NNP cord-009571-mygj2nd4 1505 9 , , , cord-009571-mygj2nd4 1505 10 it -PRON- PRP cord-009571-mygj2nd4 1505 11 is be VBZ cord-009571-mygj2nd4 1505 12 not not RB cord-009571-mygj2nd4 1505 13 regularly regularly RB cord-009571-mygj2nd4 1505 14 demonstrable demonstrable JJ cord-009571-mygj2nd4 1505 15 using use VBG cord-009571-mygj2nd4 1505 16 current current JJ cord-009571-mygj2nd4 1505 17 methods method NNS cord-009571-mygj2nd4 1505 18 . . . cord-009571-mygj2nd4 1506 1 A a DT cord-009571-mygj2nd4 1506 2 prospective prospective JJ cord-009571-mygj2nd4 1506 3 clinical clinical JJ cord-009571-mygj2nd4 1506 4 , , , cord-009571-mygj2nd4 1506 5 serologic serologic NNP cord-009571-mygj2nd4 1506 6 and and CC cord-009571-mygj2nd4 1506 7 histopathologic histopathologic NNP cord-009571-mygj2nd4 1506 8 study study NN cord-009571-mygj2nd4 1506 9 was be VBD cord-009571-mygj2nd4 1506 10 performed perform VBN cord-009571-mygj2nd4 1506 11 on on IN cord-009571-mygj2nd4 1506 12 267 267 CD cord-009571-mygj2nd4 1506 13 consecutive consecutive JJ cord-009571-mygj2nd4 1506 14 patients patient NNS cord-009571-mygj2nd4 1506 15 suspect suspect JJ cord-009571-mygj2nd4 1506 16 for for IN cord-009571-mygj2nd4 1506 17 Sjiigren Sjiigren NNP cord-009571-mygj2nd4 1506 18 's 's POS cord-009571-mygj2nd4 1506 19 syndrome syndrome NN cord-009571-mygj2nd4 1506 20 ( ( -LRB- cord-009571-mygj2nd4 1506 21 SS SS NNP cord-009571-mygj2nd4 1506 22 ) ) -RRB- cord-009571-mygj2nd4 1506 23 referred refer VBD cord-009571-mygj2nd4 1506 24 to to IN cord-009571-mygj2nd4 1506 25 an an DT cord-009571-mygj2nd4 1506 26 interdepartmental interdepartmental JJ cord-009571-mygj2nd4 1506 27 university university NN cord-009571-mygj2nd4 1506 28 clinic clinic NN cord-009571-mygj2nd4 1506 29 during during IN cord-009571-mygj2nd4 1506 30 the the DT cord-009571-mygj2nd4 1506 31 years year NNS cord-009571-mygj2nd4 1506 32 1972 1972 CD cord-009571-mygj2nd4 1506 33 - - SYM cord-009571-mygj2nd4 1506 34 1977 1977 CD cord-009571-mygj2nd4 1506 35 . . . cord-009571-mygj2nd4 1507 1 One one CD cord-009571-mygj2nd4 1507 2 hundred hundred CD cord-009571-mygj2nd4 1507 3 female female JJ cord-009571-mygj2nd4 1507 4 and and CC cord-009571-mygj2nd4 1507 5 25 25 CD cord-009571-mygj2nd4 1507 6 male male JJ cord-009571-mygj2nd4 1507 7 patients patient NNS cord-009571-mygj2nd4 1507 8 met meet VBD cord-009571-mygj2nd4 1507 9 at at RB cord-009571-mygj2nd4 1507 10 least least RBS cord-009571-mygj2nd4 1507 11 two two CD cord-009571-mygj2nd4 1507 12 of of IN cord-009571-mygj2nd4 1507 13 the the DT cord-009571-mygj2nd4 1507 14 following following JJ cord-009571-mygj2nd4 1507 15 three three CD cord-009571-mygj2nd4 1507 16 criteria criterion NNS cord-009571-mygj2nd4 1507 17 : : : cord-009571-mygj2nd4 1508 1 1 1 LS cord-009571-mygj2nd4 1508 2 ) ) -RRB- cord-009571-mygj2nd4 1508 3 lymphocyte lymphocyte NN cord-009571-mygj2nd4 1508 4 focus focus NN cord-009571-mygj2nd4 1509 1 sco.re sco.re NN cord-009571-mygj2nd4 1509 2 greater great JJR cord-009571-mygj2nd4 1509 3 than than IN cord-009571-mygj2nd4 1509 4 one one CD cord-009571-mygj2nd4 1510 1 ( ( -LRB- cord-009571-mygj2nd4 1510 2 FS FS NNP cord-009571-mygj2nd4 1510 3 > > XX cord-009571-mygj2nd4 1510 4 1 1 CD cord-009571-mygj2nd4 1510 5 ) ) -RRB- cord-009571-mygj2nd4 1510 6 on on IN cord-009571-mygj2nd4 1510 7 labial labial JJ cord-009571-mygj2nd4 1510 8 salivary salivary NNP cord-009571-mygj2nd4 1510 9 gland gland NN cord-009571-mygj2nd4 1510 10 ( ( -LRB- cord-009571-mygj2nd4 1510 11 LSG LSG NNP cord-009571-mygj2nd4 1510 12 ) ) -RRB- cord-009571-mygj2nd4 1510 13 biopsy biopsy NN cord-009571-mygj2nd4 1510 14 , , , cord-009571-mygj2nd4 1510 15 2 2 CD cord-009571-mygj2nd4 1510 16 ) ) -RRB- cord-009571-mygj2nd4 1510 17 keratoconjunctivitis keratoconjunctivitis NNP cord-009571-mygj2nd4 1510 18 sicca sicca NNP cord-009571-mygj2nd4 1510 19 ( ( -LRB- cord-009571-mygj2nd4 1510 20 KCS KCS NNP cord-009571-mygj2nd4 1510 21 ) ) -RRB- cord-009571-mygj2nd4 1510 22 , , , cord-009571-mygj2nd4 1510 23 3 3 CD cord-009571-mygj2nd4 1510 24 ) ) -RRB- cord-009571-mygj2nd4 1510 25 associated associate VBD cord-009571-mygj2nd4 1510 26 extraglandular extraglandular JJ cord-009571-mygj2nd4 1510 27 connective connective JJ cord-009571-mygj2nd4 1510 28 tissue tissue NN cord-009571-mygj2nd4 1510 29 or or CC cord-009571-mygj2nd4 1510 30 lymphoproliferative lymphoproliferative JJ cord-009571-mygj2nd4 1510 31 disorder disorder NN cord-009571-mygj2nd4 1510 32 . . . cord-009571-mygj2nd4 1511 1 Of of IN cord-009571-mygj2nd4 1511 2 the the DT cord-009571-mygj2nd4 1511 3 125 125 CD cord-009571-mygj2nd4 1511 4 SS SS NNP cord-009571-mygj2nd4 1511 5 patients patient NNS cord-009571-mygj2nd4 1511 6 , , , cord-009571-mygj2nd4 1511 7 LSG LSG NNP cord-009571-mygj2nd4 1511 8 biopsy biopsy NN cord-009571-mygj2nd4 1511 9 FS FS NNP cord-009571-mygj2nd4 1511 10 > > XX cord-009571-mygj2nd4 1512 1 1 1 CD cord-009571-mygj2nd4 1512 2 occurred occur VBD cord-009571-mygj2nd4 1512 3 in in IN cord-009571-mygj2nd4 1512 4 96 96 CD cord-009571-mygj2nd4 1512 5 % % NN cord-009571-mygj2nd4 1512 6 , , , cord-009571-mygj2nd4 1512 7 definite definite JJ cord-009571-mygj2nd4 1512 8 KCS KCS NNP cord-009571-mygj2nd4 1512 9 in in IN cord-009571-mygj2nd4 1512 10 55 55 CD cord-009571-mygj2nd4 1512 11 % % NN cord-009571-mygj2nd4 1512 12 , , , cord-009571-mygj2nd4 1512 13 and and CC cord-009571-mygj2nd4 1512 14 associated associate VBD cord-009571-mygj2nd4 1512 15 extraglandular extraglandular NNP cord-009571-mygj2nd4 1512 16 disease disease NN cord-009571-mygj2nd4 1512 17 in in IN cord-009571-mygj2nd4 1512 18 85 85 CD cord-009571-mygj2nd4 1512 19 % % NN cord-009571-mygj2nd4 1512 20 . . . cord-009571-mygj2nd4 1513 1 Rheumatoid rheumatoid JJ cord-009571-mygj2nd4 1513 2 arthritis arthritis NN cord-009571-mygj2nd4 1513 3 was be VBD cord-009571-mygj2nd4 1513 4 present present JJ cord-009571-mygj2nd4 1513 5 in in IN cord-009571-mygj2nd4 1513 6 27 27 CD cord-009571-mygj2nd4 1513 7 % % NN cord-009571-mygj2nd4 1513 8 , , , cord-009571-mygj2nd4 1513 9 scleroderma scleroderma NN cord-009571-mygj2nd4 1513 10 in in IN cord-009571-mygj2nd4 1513 11 7 7 CD cord-009571-mygj2nd4 1513 12 % % NN cord-009571-mygj2nd4 1513 13 , , , cord-009571-mygj2nd4 1513 14 systemic systemic JJ cord-009571-mygj2nd4 1513 15 lupus lupus NN cord-009571-mygj2nd4 1513 16 erythematosus erythematosus NN cord-009571-mygj2nd4 1513 17 in in IN cord-009571-mygj2nd4 1513 18 6 6 CD cord-009571-mygj2nd4 1513 19 % % NN cord-009571-mygj2nd4 1513 20 , , , cord-009571-mygj2nd4 1513 21 and and CC cord-009571-mygj2nd4 1513 22 polymyositis polymyositis NN cord-009571-mygj2nd4 1513 23 in in IN cord-009571-mygj2nd4 1513 24 2 2 CD cord-009571-mygj2nd4 1513 25 % % NN cord-009571-mygj2nd4 1513 26 . . . cord-009571-mygj2nd4 1514 1 Lymphoproliferative lymphoproliferative JJ cord-009571-mygj2nd4 1514 2 disease disease NN cord-009571-mygj2nd4 1514 3 or or CC cord-009571-mygj2nd4 1514 4 connective connective JJ cord-009571-mygj2nd4 1514 5 tissue tissue NN cord-009571-mygj2nd4 1514 6 abnormalities abnormality NNS cord-009571-mygj2nd4 1514 7 not not RB cord-009571-mygj2nd4 1514 8 fulfilling fulfil VBG cord-009571-mygj2nd4 1514 9 criteria criterion NNS cord-009571-mygj2nd4 1514 10 for for IN cord-009571-mygj2nd4 1514 11 a a DT cord-009571-mygj2nd4 1514 12 coexisting coexist VBG cord-009571-mygj2nd4 1514 13 connective connective JJ cord-009571-mygj2nd4 1514 14 tissue tissue NN cord-009571-mygj2nd4 1514 15 disease disease NN cord-009571-mygj2nd4 1514 16 ( ( -LRB- cord-009571-mygj2nd4 1514 17 CTD CTD NNP cord-009571-mygj2nd4 1514 18 ) ) -RRB- cord-009571-mygj2nd4 1514 19 were be VBD cord-009571-mygj2nd4 1514 20 present present JJ cord-009571-mygj2nd4 1514 21 in in IN cord-009571-mygj2nd4 1514 22 43 43 CD cord-009571-mygj2nd4 1514 23 % % NN cord-009571-mygj2nd4 1514 24 of of IN cord-009571-mygj2nd4 1514 25 patients patient NNS cord-009571-mygj2nd4 1514 26 . . . cord-009571-mygj2nd4 1515 1 Patients patient NNS cord-009571-mygj2nd4 1515 2 with with IN cord-009571-mygj2nd4 1515 3 extraglandular extraglandular NNP cord-009571-mygj2nd4 1515 4 disease disease NN cord-009571-mygj2nd4 1515 5 and and CC cord-009571-mygj2nd4 1515 6 KCS KCS NNP cord-009571-mygj2nd4 1515 7 almost almost RB cord-009571-mygj2nd4 1515 8 always always RB cord-009571-mygj2nd4 1515 9 had have VBD cord-009571-mygj2nd4 1515 10 a a DT cord-009571-mygj2nd4 1515 11 FS fs NN cord-009571-mygj2nd4 1515 12 > > XX cord-009571-mygj2nd4 1515 13 1 1 CD cord-009571-mygj2nd4 1515 14 ( ( -LRB- cord-009571-mygj2nd4 1515 15 33:35 33:35 CD cord-009571-mygj2nd4 1515 16 patients patient NNS cord-009571-mygj2nd4 1515 17 ) ) -RRB- cord-009571-mygj2nd4 1515 18 , , , cord-009571-mygj2nd4 1515 19 whereas whereas IN cord-009571-mygj2nd4 1515 20 patients patient NNS cord-009571-mygj2nd4 1515 21 with with IN cord-009571-mygj2nd4 1515 22 extraglandular extraglandular NNP cord-009571-mygj2nd4 1515 23 disease disease NN cord-009571-mygj2nd4 1515 24 and and CC cord-009571-mygj2nd4 1515 25 a a DT cord-009571-mygj2nd4 1515 26 FS fs NN cord-009571-mygj2nd4 1515 27 > > XX cord-009571-mygj2nd4 1515 28 1 1 CD cord-009571-mygj2nd4 1515 29 did do VBD cord-009571-mygj2nd4 1515 30 not not RB cord-009571-mygj2nd4 1515 31 necessarily necessarily RB cord-009571-mygj2nd4 1515 32 also also RB cord-009571-mygj2nd4 1515 33 have have VB cord-009571-mygj2nd4 1515 34 KCS KCS NNP cord-009571-mygj2nd4 1515 35 ( ( -LRB- cord-009571-mygj2nd4 1515 36 only only RB cord-009571-mygj2nd4 1515 37 38:77 38:77 CD cord-009571-mygj2nd4 1515 38 patients patient NNS cord-009571-mygj2nd4 1515 39 ) ) -RRB- cord-009571-mygj2nd4 1515 40 . . . cord-009571-mygj2nd4 1516 1 We -PRON- PRP cord-009571-mygj2nd4 1516 2 conclude conclude VBP cord-009571-mygj2nd4 1516 3 that that IN cord-009571-mygj2nd4 1516 4 LSG LSG NNP cord-009571-mygj2nd4 1516 5 biopsy biopsy NN cord-009571-mygj2nd4 1516 6 is be VBZ cord-009571-mygj2nd4 1516 7 more more RBR cord-009571-mygj2nd4 1516 8 sensitive sensitive JJ cord-009571-mygj2nd4 1516 9 than than IN cord-009571-mygj2nd4 1516 10 KCS KCS NNP cord-009571-mygj2nd4 1516 11 for for IN cord-009571-mygj2nd4 1516 12 detection detection NN cord-009571-mygj2nd4 1516 13 of of IN cord-009571-mygj2nd4 1516 14 SS SS NNP cord-009571-mygj2nd4 1516 15 in in IN cord-009571-mygj2nd4 1516 16 patients patient NNS cord-009571-mygj2nd4 1516 17 with with IN cord-009571-mygj2nd4 1516 18 an an DT cord-009571-mygj2nd4 1516 19 underlying underlying JJ cord-009571-mygj2nd4 1516 20 connective connective JJ cord-009571-mygj2nd4 1516 21 tissue tissue NN cord-009571-mygj2nd4 1516 22 or or CC cord-009571-mygj2nd4 1516 23 lymphoproliferative lymphoproliferative JJ cord-009571-mygj2nd4 1516 24 disorder disorder NN cord-009571-mygj2nd4 1516 25 , , , cord-009571-mygj2nd4 1516 26 and and CC cord-009571-mygj2nd4 1516 27 may may MD cord-009571-mygj2nd4 1516 28 help help VB cord-009571-mygj2nd4 1516 29 establish establish VB cord-009571-mygj2nd4 1516 30 a a DT cord-009571-mygj2nd4 1516 31 diagnosis diagnosis NN cord-009571-mygj2nd4 1516 32 in in IN cord-009571-mygj2nd4 1516 33 patients patient NNS cord-009571-mygj2nd4 1516 34 with with IN cord-009571-mygj2nd4 1516 35 clinically clinically RB cord-009571-mygj2nd4 1516 36 undiagnosed undiagnosed JJ cord-009571-mygj2nd4 1516 37 autoimmune autoimmune JJ cord-009571-mygj2nd4 1516 38 or or CC cord-009571-mygj2nd4 1516 39 lymphoproliferative lymphoproliferative JJ cord-009571-mygj2nd4 1516 40 disease disease NN cord-009571-mygj2nd4 1516 41 . . . cord-009571-mygj2nd4 1517 1 Moreover moreover RB cord-009571-mygj2nd4 1517 2 , , , cord-009571-mygj2nd4 1517 3 LSG LSG NNP cord-009571-mygj2nd4 1517 4 biopsy biopsy NN cord-009571-mygj2nd4 1517 5 is be VBZ cord-009571-mygj2nd4 1517 6 far far RB cord-009571-mygj2nd4 1517 7 superior superior JJ cord-009571-mygj2nd4 1517 8 t t NN cord-009571-mygj2nd4 1517 9 o o NN cord-009571-mygj2nd4 1517 10 clinical clinical JJ cord-009571-mygj2nd4 1517 11 symptoms symptom NNS cord-009571-mygj2nd4 1517 12 or or CC cord-009571-mygj2nd4 1517 13 signs sign NNS cord-009571-mygj2nd4 1517 14 of of IN cord-009571-mygj2nd4 1517 15 salivary salivary JJ cord-009571-mygj2nd4 1517 16 gland gland NN cord-009571-mygj2nd4 1517 17 dysfunction dysfunction NN cord-009571-mygj2nd4 1517 18 which which WDT cord-009571-mygj2nd4 1517 19 are be VBP cord-009571-mygj2nd4 1517 20 not not RB cord-009571-mygj2nd4 1517 21 specific specific JJ cord-009571-mygj2nd4 1517 22 for for IN cord-009571-mygj2nd4 1517 23 SS SS NNP cord-009571-mygj2nd4 1517 24 . . . cord-009571-mygj2nd4 1518 1 In in IN cord-009571-mygj2nd4 1518 2 fact fact NN cord-009571-mygj2nd4 1518 3 , , , cord-009571-mygj2nd4 1518 4 only only RB cord-009571-mygj2nd4 1518 5 50 50 CD cord-009571-mygj2nd4 1518 6 % % NN cord-009571-mygj2nd4 1518 7 of of IN cord-009571-mygj2nd4 1518 8 patients patient NNS cord-009571-mygj2nd4 1518 9 with with IN cord-009571-mygj2nd4 1518 10 any any DT cord-009571-mygj2nd4 1518 11 symptoms symptom NNS cord-009571-mygj2nd4 1518 12 suggestive suggestive JJ cord-009571-mygj2nd4 1518 13 of of IN cord-009571-mygj2nd4 1518 14 SS SS NNP cord-009571-mygj2nd4 1518 15 actually actually RB cord-009571-mygj2nd4 1518 16 had have VBD cord-009571-mygj2nd4 1518 17 the the DT cord-009571-mygj2nd4 1518 18 disease disease NN cord-009571-mygj2nd4 1518 19 confirmed confirm VBN cord-009571-mygj2nd4 1518 20 . . . cord-009571-mygj2nd4 1519 1 Local local JJ cord-009571-mygj2nd4 1519 2 glandular glandular JJ cord-009571-mygj2nd4 1519 3 disorders disorder NNS cord-009571-mygj2nd4 1519 4 , , , cord-009571-mygj2nd4 1519 5 anxietydepressive anxietydepressive JJ cord-009571-mygj2nd4 1519 6 syndromes syndrome NNS cord-009571-mygj2nd4 1519 7 , , , cord-009571-mygj2nd4 1519 8 and and CC cord-009571-mygj2nd4 1519 9 parasympatholytic parasympatholytic JJ cord-009571-mygj2nd4 1519 10 drugs drug NNS cord-009571-mygj2nd4 1519 11 were be VBD cord-009571-mygj2nd4 1519 12 common common JJ cord-009571-mygj2nd4 1519 13 causes cause NNS cord-009571-mygj2nd4 1519 14 of of IN cord-009571-mygj2nd4 1519 15 oral oral JJ cord-009571-mygj2nd4 1519 16 and/or and/or CC cord-009571-mygj2nd4 1519 17 ocular ocular JJ cord-009571-mygj2nd4 1519 18 complaints complaint NNS cord-009571-mygj2nd4 1519 19 . . . cord-009571-mygj2nd4 1520 1 Our -PRON- PRP$ cord-009571-mygj2nd4 1520 2 study study NN cord-009571-mygj2nd4 1520 3 suggests suggest VBZ cord-009571-mygj2nd4 1520 4 a a DT cord-009571-mygj2nd4 1520 5 new new JJ cord-009571-mygj2nd4 1520 6 definition definition NN cord-009571-mygj2nd4 1520 7 of of IN cord-009571-mygj2nd4 1520 8 SS SS NNP cord-009571-mygj2nd4 1520 9 as as IN cord-009571-mygj2nd4 1520 10 an an DT cord-009571-mygj2nd4 1520 11 autoimmune autoimmune JJ cord-009571-mygj2nd4 1520 12 exocrinopathy exocrinopathy NN cord-009571-mygj2nd4 1520 13 based base VBN cord-009571-mygj2nd4 1520 14 on on IN cord-009571-mygj2nd4 1520 15 the the DT cord-009571-mygj2nd4 1520 16 utility utility NN cord-009571-mygj2nd4 1520 17 and and CC cord-009571-mygj2nd4 1520 18 diagnostic diagnostic JJ cord-009571-mygj2nd4 1520 19 value value NN cord-009571-mygj2nd4 1520 20 of of IN cord-009571-mygj2nd4 1520 21 LSG LSG NNP cord-009571-mygj2nd4 1520 22 biopsy biopsy NNP cord-009571-mygj2nd4 1520 23 . . . cord-009571-mygj2nd4 1521 1 In in IN cord-009571-mygj2nd4 1521 2 view view NN cord-009571-mygj2nd4 1521 3 of of IN cord-009571-mygj2nd4 1521 4 the the DT cord-009571-mygj2nd4 1521 5 HLA HLA NNP cord-009571-mygj2nd4 1521 6 - - HYPH cord-009571-mygj2nd4 1521 7 B8 B8 NNP cord-009571-mygj2nd4 1521 8 association association NN cord-009571-mygj2nd4 1521 9 and and CC cord-009571-mygj2nd4 1521 10 unique unique JJ cord-009571-mygj2nd4 1521 11 precipitating precipitate VBG cord-009571-mygj2nd4 1521 12 antibodies antibody NNS cord-009571-mygj2nd4 1521 13 to to IN cord-009571-mygj2nd4 1521 14 nuclear nuclear JJ cord-009571-mygj2nd4 1521 15 antigens antigen NNS cord-009571-mygj2nd4 1521 16 ( ( -LRB- cord-009571-mygj2nd4 1521 17 Ha ha UH cord-009571-mygj2nd4 1521 18 , , , cord-009571-mygj2nd4 1521 19 SS SS NNP cord-009571-mygj2nd4 1521 20 - - HYPH cord-009571-mygj2nd4 1521 21 A A NNP cord-009571-mygj2nd4 1521 22 , , , cord-009571-mygj2nd4 1521 23 SS SS NNP cord-009571-mygj2nd4 1521 24 - - HYPH cord-009571-mygj2nd4 1521 25 B B NNP cord-009571-mygj2nd4 1521 26 ) ) -RRB- cord-009571-mygj2nd4 1521 27 found find VBD cord-009571-mygj2nd4 1521 28 in in IN cord-009571-mygj2nd4 1521 29 SS SS NNP cord-009571-mygj2nd4 1521 30 , , , cord-009571-mygj2nd4 1521 31 autoimmune autoimmune JJ cord-009571-mygj2nd4 1521 32 exocrinopathy exocrinopathy NN cord-009571-mygj2nd4 1521 33 might may MD cord-009571-mygj2nd4 1521 34 be be VB cord-009571-mygj2nd4 1521 35 considered consider VBN cord-009571-mygj2nd4 1521 36 a a DT cord-009571-mygj2nd4 1521 37 genetically genetically RB cord-009571-mygj2nd4 1521 38 and and CC cord-009571-mygj2nd4 1521 39 serologically serologically RB cord-009571-mygj2nd4 1521 40 distinct distinct JJ cord-009571-mygj2nd4 1521 41 connective connective JJ cord-009571-mygj2nd4 1521 42 tissue tissue NN cord-009571-mygj2nd4 1521 43 disease disease NN cord-009571-mygj2nd4 1521 44 related relate VBD cord-009571-mygj2nd4 1521 45 t t NN cord-009571-mygj2nd4 1521 46 o o NN cord-009571-mygj2nd4 1521 47 but but CC cord-009571-mygj2nd4 1521 48 separable separable JJ cord-009571-mygj2nd4 1521 49 from from IN cord-009571-mygj2nd4 1521 50 other other JJ cord-009571-mygj2nd4 1521 51 connective connective JJ cord-009571-mygj2nd4 1521 52 tissue tissue NN cord-009571-mygj2nd4 1521 53 diseases disease NNS cord-009571-mygj2nd4 1521 54 . . . cord-009571-mygj2nd4 1522 1 Rheumatoid rheumatoid JJ cord-009571-mygj2nd4 1522 2 arthritis arthritis NN cord-009571-mygj2nd4 1522 3 or or CC cord-009571-mygj2nd4 1522 4 a a DT cord-009571-mygj2nd4 1522 5 coexisting coexist VBG cord-009571-mygj2nd4 1522 6 connective connective JJ cord-009571-mygj2nd4 1522 7 tissue tissue NN cord-009571-mygj2nd4 1522 8 disease disease NN cord-009571-mygj2nd4 1522 9 occurs occur VBZ cord-009571-mygj2nd4 1522 10 in in IN cord-009571-mygj2nd4 1522 11 only only RB cord-009571-mygj2nd4 1522 12 a a DT cord-009571-mygj2nd4 1522 13 minority minority NN cord-009571-mygj2nd4 1522 14 of of IN cord-009571-mygj2nd4 1522 15 patients patient NNS cord-009571-mygj2nd4 1522 16 with with IN cord-009571-mygj2nd4 1522 17 autoimmune autoimmune JJ cord-009571-mygj2nd4 1522 18 exocrinopathy exocrinopathy NNP cord-009571-mygj2nd4 1522 19 and and CC cord-009571-mygj2nd4 1522 20 should should MD cord-009571-mygj2nd4 1522 21 not not RB cord-009571-mygj2nd4 1522 22 be be VB cord-009571-mygj2nd4 1522 23 a a DT cord-009571-mygj2nd4 1522 24 requirement requirement NN cord-009571-mygj2nd4 1522 25 for for IN cord-009571-mygj2nd4 1522 26 diagnosis diagnosis NN cord-009571-mygj2nd4 1522 27 . . . cord-009571-mygj2nd4 1523 1 Degradation degradation NN cord-009571-mygj2nd4 1523 2 of of IN cord-009571-mygj2nd4 1523 3 collagen collagen NN cord-009571-mygj2nd4 1523 4 at at IN cord-009571-mygj2nd4 1523 5 sites site NNS cord-009571-mygj2nd4 1523 6 of of IN cord-009571-mygj2nd4 1523 7 tissue tissue NN cord-009571-mygj2nd4 1523 8 injury injury NN cord-009571-mygj2nd4 1523 9 and and CC cord-009571-mygj2nd4 1523 10 inflammation inflammation NN cord-009571-mygj2nd4 1523 11 is be VBZ cord-009571-mygj2nd4 1523 12 effected effect VBN cord-009571-mygj2nd4 1523 13 by by IN cord-009571-mygj2nd4 1523 14 the the DT cord-009571-mygj2nd4 1523 15 dual dual JJ cord-009571-mygj2nd4 1523 16 action action NN cord-009571-mygj2nd4 1523 17 of of IN cord-009571-mygj2nd4 1523 18 collagenase collagenase NNP cord-009571-mygj2nd4 1523 19 and and CC cord-009571-mygj2nd4 1523 20 nonspecific nonspecific JJ cord-009571-mygj2nd4 1523 21 proteases protease NNS cord-009571-mygj2nd4 1523 22 present present JJ cord-009571-mygj2nd4 1523 23 in in IN cord-009571-mygj2nd4 1523 24 neutrophils neutrophil NNS cord-009571-mygj2nd4 1523 25 , , , cord-009571-mygj2nd4 1523 26 macrophages macrophage NNS cord-009571-mygj2nd4 1523 27 , , , cord-009571-mygj2nd4 1523 28 and and CC cord-009571-mygj2nd4 1523 29 other other JJ cord-009571-mygj2nd4 1523 30 cells cell NNS cord-009571-mygj2nd4 1523 31 . . . cord-009571-mygj2nd4 1524 1 Monocytes monocyte NNS cord-009571-mygj2nd4 1524 2 eventually eventually RB cord-009571-mygj2nd4 1524 3 accumulate accumulate VBP cord-009571-mygj2nd4 1524 4 at at IN cord-009571-mygj2nd4 1524 5 such such JJ cord-009571-mygj2nd4 1524 6 sites site NNS cord-009571-mygj2nd4 1524 7 and and CC cord-009571-mygj2nd4 1524 8 as as IN cord-009571-mygj2nd4 1524 9 macrophages macrophage NNS cord-009571-mygj2nd4 1524 10 perform perform VBP cord-009571-mygj2nd4 1524 11 important important JJ cord-009571-mygj2nd4 1524 12 phagocytic phagocytic JJ cord-009571-mygj2nd4 1524 13 functions function NNS cord-009571-mygj2nd4 1524 14 . . . cord-009571-mygj2nd4 1525 1 Mechanisms mechanism NNS cord-009571-mygj2nd4 1525 2 whereby whereby WRB cord-009571-mygj2nd4 1525 3 monocytes monocyte NNS cord-009571-mygj2nd4 1525 4 are be VBP cord-009571-mygj2nd4 1525 5 attracted attract VBN cord-009571-mygj2nd4 1525 6 to to IN cord-009571-mygj2nd4 1525 7 areas area NNS cord-009571-mygj2nd4 1525 8 of of IN cord-009571-mygj2nd4 1525 9 in in IN cord-009571-mygj2nd4 1525 10 - - HYPH cord-009571-mygj2nd4 1525 11 flammatory flammatory NN cord-009571-mygj2nd4 1525 12 reactions reaction NNS cord-009571-mygj2nd4 1525 13 are be VBP cord-009571-mygj2nd4 1525 14 incompletely incompletely RB cord-009571-mygj2nd4 1525 15 understood understand VBN cord-009571-mygj2nd4 1525 16 , , , cord-009571-mygj2nd4 1525 17 although although IN cord-009571-mygj2nd4 1525 18 several several JJ cord-009571-mygj2nd4 1525 19 different different JJ cord-009571-mygj2nd4 1525 20 chemotactic chemotactic JJ cord-009571-mygj2nd4 1525 21 factors factor NNS cord-009571-mygj2nd4 1525 22 have have VBP cord-009571-mygj2nd4 1525 23 been be VBN cord-009571-mygj2nd4 1525 24 described describe VBN cord-009571-mygj2nd4 1525 25 . . . cord-009571-mygj2nd4 1526 1 We -PRON- PRP cord-009571-mygj2nd4 1526 2 have have VBP cord-009571-mygj2nd4 1526 3 measured measure VBN cord-009571-mygj2nd4 1526 4 the the DT cord-009571-mygj2nd4 1526 5 chemotactic chemotactic JJ cord-009571-mygj2nd4 1526 6 response response NN cord-009571-mygj2nd4 1526 7 of of IN cord-009571-mygj2nd4 1526 8 normal normal JJ cord-009571-mygj2nd4 1526 9 human human JJ cord-009571-mygj2nd4 1526 10 peripheral peripheral JJ cord-009571-mygj2nd4 1526 11 blood blood NN cord-009571-mygj2nd4 1526 12 monocytes monocyte NNS cord-009571-mygj2nd4 1526 13 to to IN cord-009571-mygj2nd4 1526 14 different different JJ cord-009571-mygj2nd4 1526 15 types type NNS cord-009571-mygj2nd4 1526 16 of of IN cord-009571-mygj2nd4 1526 17 human human JJ cord-009571-mygj2nd4 1526 18 collagens collagen NNS cord-009571-mygj2nd4 1526 19 and and CC cord-009571-mygj2nd4 1526 20 collagen collagen NN cord-009571-mygj2nd4 1526 21 degradation degradation NN cord-009571-mygj2nd4 1526 22 peptides peptide NNS cord-009571-mygj2nd4 1526 23 by by IN cord-009571-mygj2nd4 1526 24 a a DT cord-009571-mygj2nd4 1526 25 modified modify VBN cord-009571-mygj2nd4 1526 26 Boyden Boyden NNP cord-009571-mygj2nd4 1526 27 technique technique NN cord-009571-mygj2nd4 1526 28 . . . cord-009571-mygj2nd4 1527 1 Chemotactic chemotactic JJ cord-009571-mygj2nd4 1527 2 activity activity NN cord-009571-mygj2nd4 1527 3 ( ( -LRB- cord-009571-mygj2nd4 1527 4 CTX CTX NNP cord-009571-mygj2nd4 1527 5 ) ) -RRB- cord-009571-mygj2nd4 1527 6 expressed express VBD cord-009571-mygj2nd4 1527 7 as as IN cord-009571-mygj2nd4 1527 8 monocytes monocyte NNS cord-009571-mygj2nd4 1527 9 per per IN cord-009571-mygj2nd4 1527 10 oil oil NN cord-009571-mygj2nd4 1527 11 immersion immersion NN cord-009571-mygj2nd4 1527 12 field field NN cord-009571-mygj2nd4 1527 13 for for IN cord-009571-mygj2nd4 1527 14 various various JJ cord-009571-mygj2nd4 1527 15 preparations preparation NNS cord-009571-mygj2nd4 1527 16 tested test VBN cord-009571-mygj2nd4 1527 17 were be VBD cord-009571-mygj2nd4 1527 18 as as IN cord-009571-mygj2nd4 1527 19 follows follow VBZ cord-009571-mygj2nd4 1527 20 : : : cord-009571-mygj2nd4 1527 21 type type NN cord-009571-mygj2nd4 1527 22 I -PRON- PRP cord-009571-mygj2nd4 1527 23 collagen collagen NN cord-009571-mygj2nd4 1527 24 ( ( -LRB- cord-009571-mygj2nd4 1527 25 1.8 1.8 CD cord-009571-mygj2nd4 1527 26 p p NN cord-009571-mygj2nd4 1527 27 M M NNP cord-009571-mygj2nd4 1527 28 collagenase collagenase NN cord-009571-mygj2nd4 1527 29 retained retain VBD cord-009571-mygj2nd4 1527 30 chemotactic chemotactic JJ cord-009571-mygj2nd4 1527 31 activity activity NN cord-009571-mygj2nd4 1527 32 . . . cord-009571-mygj2nd4 1528 1 Additional additional JJ cord-009571-mygj2nd4 1528 2 studies study NNS cord-009571-mygj2nd4 1528 3 were be VBD cord-009571-mygj2nd4 1528 4 undertaken undertake VBN cord-009571-mygj2nd4 1528 5 with with IN cord-009571-mygj2nd4 1528 6 synthetic synthetic JJ cord-009571-mygj2nd4 1528 7 tri tri JJ cord-009571-mygj2nd4 1528 8 - - HYPH cord-009571-mygj2nd4 1528 9 and and CC cord-009571-mygj2nd4 1528 10 dipeptides dipeptide NNS cord-009571-mygj2nd4 1528 11 containing contain VBG cord-009571-mygj2nd4 1528 12 amino amino JJ cord-009571-mygj2nd4 1528 13 acids acid NNS cord-009571-mygj2nd4 1528 14 common common JJ cord-009571-mygj2nd4 1528 15 to to IN cord-009571-mygj2nd4 1528 16 the the DT cord-009571-mygj2nd4 1528 17 three three CD cord-009571-mygj2nd4 1528 18 different different JJ cord-009571-mygj2nd4 1528 19 collagens collagen NNS cord-009571-mygj2nd4 1528 20 . . . cord-009571-mygj2nd4 1529 1 Peptides peptide NNS cord-009571-mygj2nd4 1529 2 containing contain VBG cord-009571-mygj2nd4 1529 3 proline proline NN cord-009571-mygj2nd4 1529 4 or or CC cord-009571-mygj2nd4 1529 5 hydroxyproline hydroxyproline NN cord-009571-mygj2nd4 1529 6 ( ( -LRB- cord-009571-mygj2nd4 1529 7 for for IN cord-009571-mygj2nd4 1529 8 example example NN cord-009571-mygj2nd4 1529 9 , , , cord-009571-mygj2nd4 1529 10 Gly Gly NNP cord-009571-mygj2nd4 1529 11 - - HYPH cord-009571-mygj2nd4 1529 12 Pro Pro NNP cord-009571-mygj2nd4 1529 13 , , , cord-009571-mygj2nd4 1529 14 Gly Gly NNP cord-009571-mygj2nd4 1529 15 - - HYPH cord-009571-mygj2nd4 1529 16 Hyp Hyp NNP cord-009571-mygj2nd4 1529 17 , , , cord-009571-mygj2nd4 1529 18 Pro pro JJ cord-009571-mygj2nd4 1529 19 - - JJ cord-009571-mygj2nd4 1529 20 Hyp Hyp NNP cord-009571-mygj2nd4 1529 21 , , , cord-009571-mygj2nd4 1529 22 Gly Gly NNP cord-009571-mygj2nd4 1529 23 - - HYPH cord-009571-mygj2nd4 1529 24 Pro Pro NNP cord-009571-mygj2nd4 1529 25 - - HYPH cord-009571-mygj2nd4 1529 26 Hyp Hyp NNP cord-009571-mygj2nd4 1529 27 , , , cord-009571-mygj2nd4 1529 28 and and CC cord-009571-mygj2nd4 1529 29 Gly Gly NNP cord-009571-mygj2nd4 1529 30 - - HYPH cord-009571-mygj2nd4 1529 31 Pro Pro NNP cord-009571-mygj2nd4 1529 32 - - NNP cord-009571-mygj2nd4 1529 33 Ala Ala NNP cord-009571-mygj2nd4 1529 34 ) ) -RRB- cord-009571-mygj2nd4 1529 35 were be VBD cord-009571-mygj2nd4 1529 36 chemotactic chemotactic VBN cord-009571-mygj2nd4 1529 37 for for IN cord-009571-mygj2nd4 1529 38 monocytes monocyte NNS cord-009571-mygj2nd4 1529 39 at at IN cord-009571-mygj2nd4 1529 40 concentrations concentration NNS cord-009571-mygj2nd4 1529 41 ranging range VBG cord-009571-mygj2nd4 1529 42 between between IN cord-009571-mygj2nd4 1529 43 lo- lo- NNP cord-009571-mygj2nd4 1529 44 ' ' '' cord-009571-mygj2nd4 1529 45 and and CC cord-009571-mygj2nd4 1529 46 10-BM 10-bm CD cord-009571-mygj2nd4 1529 47 . . . cord-009571-mygj2nd4 1530 1 These these DT cord-009571-mygj2nd4 1530 2 data datum NNS cord-009571-mygj2nd4 1530 3 suggest suggest VBP cord-009571-mygj2nd4 1530 4 that that IN cord-009571-mygj2nd4 1530 5 peptides peptide NNS cord-009571-mygj2nd4 1530 6 generated generate VBN cord-009571-mygj2nd4 1530 7 as as IN cord-009571-mygj2nd4 1530 8 a a DT cord-009571-mygj2nd4 1530 9 result result NN cord-009571-mygj2nd4 1530 10 of of IN cord-009571-mygj2nd4 1530 11 degradation degradation NN cord-009571-mygj2nd4 1530 12 of of IN cord-009571-mygj2nd4 1530 13 collagen collagen NN cord-009571-mygj2nd4 1530 14 by by IN cord-009571-mygj2nd4 1530 15 collagenase collagenase NNP cord-009571-mygj2nd4 1530 16 and and CC cord-009571-mygj2nd4 1530 17 other other JJ cord-009571-mygj2nd4 1530 18 proteases protease NNS cord-009571-mygj2nd4 1530 19 might may MD cord-009571-mygj2nd4 1530 20 function function VB cord-009571-mygj2nd4 1530 21 to to TO cord-009571-mygj2nd4 1530 22 chemotactically chemotactically RB cord-009571-mygj2nd4 1530 23 attract attract VB cord-009571-mygj2nd4 1530 24 monocytes monocyte NNS cord-009571-mygj2nd4 1530 25 to to IN cord-009571-mygj2nd4 1530 26 sites site NNS cord-009571-mygj2nd4 1530 27 of of IN cord-009571-mygj2nd4 1530 28 tissue tissue NN cord-009571-mygj2nd4 1530 29 damage damage NN cord-009571-mygj2nd4 1530 30 and and CC cord-009571-mygj2nd4 1530 31 inflammation inflammation NN cord-009571-mygj2nd4 1530 32 in in IN cord-009571-mygj2nd4 1530 33 vivo vivo NNP cord-009571-mygj2nd4 1530 34 . . . cord-009571-mygj2nd4 1531 1 Although although IN cord-009571-mygj2nd4 1531 2 it -PRON- PRP cord-009571-mygj2nd4 1531 3 is be VBZ cord-009571-mygj2nd4 1531 4 known know VBN cord-009571-mygj2nd4 1531 5 that that IN cord-009571-mygj2nd4 1531 6 a a DT cord-009571-mygj2nd4 1531 7 small small JJ cord-009571-mygj2nd4 1531 8 percentage percentage NN cord-009571-mygj2nd4 1531 9 of of IN cord-009571-mygj2nd4 1531 10 patients patient NNS cord-009571-mygj2nd4 1531 11 with with IN cord-009571-mygj2nd4 1531 12 Sjbgren Sjbgren NNP cord-009571-mygj2nd4 1531 13 's 's POS cord-009571-mygj2nd4 1531 14 syndrome syndrome NN cord-009571-mygj2nd4 1531 15 ( ( -LRB- cord-009571-mygj2nd4 1531 16 SS SS NNP cord-009571-mygj2nd4 1531 17 ) ) -RRB- cord-009571-mygj2nd4 1531 18 may may MD cord-009571-mygj2nd4 1531 19 develop develop VB cord-009571-mygj2nd4 1531 20 malignant malignant JJ cord-009571-mygj2nd4 1531 21 lymphoma lymphoma NN cord-009571-mygj2nd4 1531 22 , , , cord-009571-mygj2nd4 1531 23 the the DT cord-009571-mygj2nd4 1531 24 frequency frequency NN cord-009571-mygj2nd4 1531 25 of of IN cord-009571-mygj2nd4 1531 26 SS SS NNP cord-009571-mygj2nd4 1531 27 in in IN cord-009571-mygj2nd4 1531 28 lymphoma lymphoma NN cord-009571-mygj2nd4 1531 29 has have VBZ cord-009571-mygj2nd4 1531 30 not not RB cord-009571-mygj2nd4 1531 31 been be VBN cord-009571-mygj2nd4 1531 32 established establish VBN cord-009571-mygj2nd4 1531 33 . . . cord-009571-mygj2nd4 1532 1 Therefore therefore RB cord-009571-mygj2nd4 1532 2 , , , cord-009571-mygj2nd4 1532 3 50 50 CD cord-009571-mygj2nd4 1532 4 consecutive consecutive JJ cord-009571-mygj2nd4 1532 5 untreated untreated JJ cord-009571-mygj2nd4 1532 6 patients patient NNS cord-009571-mygj2nd4 1532 7 with with IN cord-009571-mygj2nd4 1532 8 biopsy biopsy NN cord-009571-mygj2nd4 1532 9 - - HYPH cord-009571-mygj2nd4 1532 10 proven prove VBN cord-009571-mygj2nd4 1532 11 non non JJ cord-009571-mygj2nd4 1532 12 - - JJ cord-009571-mygj2nd4 1532 13 Hodgkin Hodgkin NNP cord-009571-mygj2nd4 1532 14 's 's POS cord-009571-mygj2nd4 1532 15 lymphoma lymphoma NN cord-009571-mygj2nd4 1532 16 were be VBD cord-009571-mygj2nd4 1532 17 screened screen VBN cord-009571-mygj2nd4 1532 18 to to TO cord-009571-mygj2nd4 1532 19 establish establish VB cord-009571-mygj2nd4 1532 20 the the DT cord-009571-mygj2nd4 1532 21 prevalence prevalence NN cord-009571-mygj2nd4 1532 22 of of IN cord-009571-mygj2nd4 1532 23 SS SS NNP cord-009571-mygj2nd4 1532 24 . . . cord-009571-mygj2nd4 1533 1 Patients patient NNS cord-009571-mygj2nd4 1533 2 were be VBD cord-009571-mygj2nd4 1533 3 defined define VBN cord-009571-mygj2nd4 1533 4 as as IN cord-009571-mygj2nd4 1533 5 having have VBG cord-009571-mygj2nd4 1533 6 SS SS NNP cord-009571-mygj2nd4 1533 7 if if IN cord-009571-mygj2nd4 1533 8 they -PRON- PRP cord-009571-mygj2nd4 1533 9 exhibited exhibit VBD cord-009571-mygj2nd4 1533 10 objective objective JJ cord-009571-mygj2nd4 1533 11 evidence evidence NN cord-009571-mygj2nd4 1533 12 of of IN cord-009571-mygj2nd4 1533 13 keratoconjunctivitis keratoconjunctivitis NNP cord-009571-mygj2nd4 1533 14 sicca sicca NNP cord-009571-mygj2nd4 1533 15 and and CC cord-009571-mygj2nd4 1533 16 xerostomia xerostomia NN cord-009571-mygj2nd4 1533 17 . . . cord-009571-mygj2nd4 1534 1 All all DT cord-009571-mygj2nd4 1534 2 were be VBD cord-009571-mygj2nd4 1534 3 assessed assess VBN cord-009571-mygj2nd4 1534 4 by by IN cord-009571-mygj2nd4 1534 5 history history NN cord-009571-mygj2nd4 1534 6 , , , cord-009571-mygj2nd4 1534 7 physical physical JJ cord-009571-mygj2nd4 1534 8 examination examination NN cord-009571-mygj2nd4 1534 9 , , , cord-009571-mygj2nd4 1534 10 Schirmer Schirmer NNP cord-009571-mygj2nd4 1534 11 test test NN cord-009571-mygj2nd4 1534 12 , , , cord-009571-mygj2nd4 1534 13 Rose Rose NNP cord-009571-mygj2nd4 1534 14 Bengal Bengal NNP cord-009571-mygj2nd4 1534 15 staining staining NN cord-009571-mygj2nd4 1534 16 of of IN cord-009571-mygj2nd4 1534 17 the the DT cord-009571-mygj2nd4 1534 18 cornea cornea NN cord-009571-mygj2nd4 1534 19 and and CC cord-009571-mygj2nd4 1534 20 bulbar bulbar NN cord-009571-mygj2nd4 1534 21 conjunctiva conjunctiva NN cord-009571-mygj2nd4 1534 22 , , , cord-009571-mygj2nd4 1534 23 and and CC cord-009571-mygj2nd4 1534 24 if if IN cord-009571-mygj2nd4 1534 25 possible possible JJ cord-009571-mygj2nd4 1534 26 a a DT cord-009571-mygj2nd4 1534 27 serial serial JJ cord-009571-mygj2nd4 1534 28 salivary salivary NN cord-009571-mygj2nd4 1534 29 scintiscan scintiscan NNP cord-009571-mygj2nd4 1534 30 , , , cord-009571-mygj2nd4 1534 31 serologic serologic NNP cord-009571-mygj2nd4 1534 32 studies study NNS cord-009571-mygj2nd4 1534 33 , , , cord-009571-mygj2nd4 1534 34 and and CC cord-009571-mygj2nd4 1534 35 a a DT cord-009571-mygj2nd4 1534 36 lip lip NN cord-009571-mygj2nd4 1534 37 biopsy biopsy NN cord-009571-mygj2nd4 1534 38 . . . cord-009571-mygj2nd4 1535 1 Of of IN cord-009571-mygj2nd4 1535 2 the the DT cord-009571-mygj2nd4 1535 3 50 50 CD cord-009571-mygj2nd4 1535 4 patients patient NNS cord-009571-mygj2nd4 1535 5 seen see VBN cord-009571-mygj2nd4 1535 6 , , , cord-009571-mygj2nd4 1535 7 13 13 CD cord-009571-mygj2nd4 1535 8 were be VBD cord-009571-mygj2nd4 1535 9 identified identify VBN cord-009571-mygj2nd4 1535 10 as as IN cord-009571-mygj2nd4 1535 11 having have VBG cord-009571-mygj2nd4 1535 12 SS SS NNP cord-009571-mygj2nd4 1535 13 . . . cord-009571-mygj2nd4 1536 1 Of of IN cord-009571-mygj2nd4 1536 2 these these DT cord-009571-mygj2nd4 1536 3 , , , cord-009571-mygj2nd4 1536 4 all all DT cord-009571-mygj2nd4 1536 5 13 13 CD cord-009571-mygj2nd4 1536 6 had have VBD cord-009571-mygj2nd4 1536 7 a a DT cord-009571-mygj2nd4 1536 8 history history NN cord-009571-mygj2nd4 1536 9 of of IN cord-009571-mygj2nd4 1536 10 xerostomia xerostomia NNP cord-009571-mygj2nd4 1536 11 and and CC cord-009571-mygj2nd4 1536 12 keratoconjunctivitis keratoconjunctivitis NNP cord-009571-mygj2nd4 1536 13 sicca sicca NNP cord-009571-mygj2nd4 1536 14 , , , cord-009571-mygj2nd4 1536 15 while while IN cord-009571-mygj2nd4 1536 16 12 12 CD cord-009571-mygj2nd4 1536 17 had have VBD cord-009571-mygj2nd4 1536 18 a a DT cord-009571-mygj2nd4 1536 19 positive positive JJ cord-009571-mygj2nd4 1536 20 Schirmer Schirmer NNP cord-009571-mygj2nd4 1536 21 test test NN cord-009571-mygj2nd4 1536 22 , , , cord-009571-mygj2nd4 1536 23 5 5 CD cord-009571-mygj2nd4 1536 24 had have VBD cord-009571-mygj2nd4 1536 25 positive positive JJ cord-009571-mygj2nd4 1536 26 staining staining NN cord-009571-mygj2nd4 1536 27 with with IN cord-009571-mygj2nd4 1536 28 Rose Rose NNP cord-009571-mygj2nd4 1536 29 Bengal Bengal NNP cord-009571-mygj2nd4 1536 30 , , , cord-009571-mygj2nd4 1536 31 and and CC cord-009571-mygj2nd4 1536 32 3 3 CD cord-009571-mygj2nd4 1536 33 had have VBD cord-009571-mygj2nd4 1536 34 a a DT cord-009571-mygj2nd4 1536 35 markedly markedly RB cord-009571-mygj2nd4 1536 36 abnormal abnormal JJ cord-009571-mygj2nd4 1536 37 salivary salivary NN cord-009571-mygj2nd4 1536 38 gland gland NN cord-009571-mygj2nd4 1536 39 scan scan NN cord-009571-mygj2nd4 1536 40 . . . cord-009571-mygj2nd4 1537 1 Three three CD cord-009571-mygj2nd4 1537 2 had have VBD cord-009571-mygj2nd4 1537 3 a a DT cord-009571-mygj2nd4 1537 4 positive positive JJ cord-009571-mygj2nd4 1537 5 anti anti JJ cord-009571-mygj2nd4 1537 6 - - JJ cord-009571-mygj2nd4 1537 7 nuclear nuclear JJ cord-009571-mygj2nd4 1537 8 antibody antibody NN cord-009571-mygj2nd4 1537 9 ( ( -LRB- cord-009571-mygj2nd4 1537 10 ANA ANA NNP cord-009571-mygj2nd4 1537 11 ) ) -RRB- cord-009571-mygj2nd4 1537 12 and and CC cord-009571-mygj2nd4 1537 13 1 1 CD cord-009571-mygj2nd4 1537 14 anti anti JJ cord-009571-mygj2nd4 1537 15 - - JJ cord-009571-mygj2nd4 1537 16 salivary salivary JJ cord-009571-mygj2nd4 1537 17 duct duct NN cord-009571-mygj2nd4 1537 18 antibody antibody NN cord-009571-mygj2nd4 1537 19 . . . cord-009571-mygj2nd4 1538 1 Of of IN cord-009571-mygj2nd4 1538 2 the the DT cord-009571-mygj2nd4 1538 3 13 13 CD cord-009571-mygj2nd4 1538 4 with with IN cord-009571-mygj2nd4 1538 5 SS SS NNP cord-009571-mygj2nd4 1538 6 , , , cord-009571-mygj2nd4 1538 7 6 6 CD cord-009571-mygj2nd4 1538 8 had have VBD cord-009571-mygj2nd4 1538 9 adequate adequate JJ cord-009571-mygj2nd4 1538 10 lip lip NN cord-009571-mygj2nd4 1538 11 biopsies biopsy NNS cord-009571-mygj2nd4 1538 12 . . . cord-009571-mygj2nd4 1539 1 Of of IN cord-009571-mygj2nd4 1539 2 these these DT cord-009571-mygj2nd4 1539 3 , , , cord-009571-mygj2nd4 1539 4 3 3 CD cord-009571-mygj2nd4 1539 5 were be VBD cord-009571-mygj2nd4 1539 6 normal normal JJ cord-009571-mygj2nd4 1539 7 , , , cord-009571-mygj2nd4 1539 8 and and CC cord-009571-mygj2nd4 1539 9 2 2 CD cord-009571-mygj2nd4 1539 10 showed show VBD cord-009571-mygj2nd4 1539 11 mild mild JJ cord-009571-mygj2nd4 1539 12 , , , cord-009571-mygj2nd4 1539 13 non non JJ cord-009571-mygj2nd4 1539 14 - - JJ cord-009571-mygj2nd4 1539 15 specific specific JJ cord-009571-mygj2nd4 1539 16 lymphocytic lymphocytic JJ cord-009571-mygj2nd4 1539 17 infiltration infiltration NN cord-009571-mygj2nd4 1539 18 , , , cord-009571-mygj2nd4 1539 19 while while IN cord-009571-mygj2nd4 1539 20 1 1 CD cord-009571-mygj2nd4 1539 21 was be VBD cord-009571-mygj2nd4 1539 22 highly highly RB cord-009571-mygj2nd4 1539 23 iuggestive iuggestive JJ cord-009571-mygj2nd4 1539 24 of of IN cord-009571-mygj2nd4 1539 25 SS SS NNP cord-009571-mygj2nd4 1539 26 with with IN cord-009571-mygj2nd4 1539 27 lymphocytic lymphocytic JJ cord-009571-mygj2nd4 1539 28 infiltration infiltration NN cord-009571-mygj2nd4 1539 29 and and CC cord-009571-mygj2nd4 1539 30 salivary salivary NN cord-009571-mygj2nd4 1539 31 gland gland NN cord-009571-mygj2nd4 1539 32 atrophy atrophy NN cord-009571-mygj2nd4 1539 33 . . . cord-009571-mygj2nd4 1540 1 Five five CD cord-009571-mygj2nd4 1540 2 of of IN cord-009571-mygj2nd4 1540 3 the the DT cord-009571-mygj2nd4 1540 4 13 13 CD cord-009571-mygj2nd4 1540 5 had have VBD cord-009571-mygj2nd4 1540 6 musculoskeletal musculoskeletal JJ cord-009571-mygj2nd4 1540 7 complaints complaint NNS cord-009571-mygj2nd4 1540 8 , , , cord-009571-mygj2nd4 1540 9 4 4 CD cord-009571-mygj2nd4 1540 10 had have VBD cord-009571-mygj2nd4 1540 11 classic classic JJ cord-009571-mygj2nd4 1540 12 or or CC cord-009571-mygj2nd4 1540 13 atypical atypical JJ cord-009571-mygj2nd4 1540 14 Raynaud Raynaud NNP cord-009571-mygj2nd4 1540 15 's 's POS cord-009571-mygj2nd4 1540 16 phenomenon phenomenon NN cord-009571-mygj2nd4 1540 17 , , , cord-009571-mygj2nd4 1540 18 and and CC cord-009571-mygj2nd4 1540 19 2 2 CD cord-009571-mygj2nd4 1540 20 had have VBD cord-009571-mygj2nd4 1540 21 a a DT cord-009571-mygj2nd4 1540 22 concurrent concurrent JJ cord-009571-mygj2nd4 1540 23 diffuse diffuse JJ cord-009571-mygj2nd4 1540 24 connective connective JJ cord-009571-mygj2nd4 1540 25 tissue tissue NN cord-009571-mygj2nd4 1540 26 disease disease NN cord-009571-mygj2nd4 1540 27 ( ( -LRB- cord-009571-mygj2nd4 1540 28 1 1 CD cord-009571-mygj2nd4 1540 29 had have VBD cord-009571-mygj2nd4 1540 30 scleroderma scleroderma NNS cord-009571-mygj2nd4 1540 31 and and CC cord-009571-mygj2nd4 1540 32 1 1 CD cord-009571-mygj2nd4 1540 33 had have VBD cord-009571-mygj2nd4 1540 34 probable probable JJ cord-009571-mygj2nd4 1540 35 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1540 36 arthritis arthritis NN cord-009571-mygj2nd4 1540 37 ) ) -RRB- cord-009571-mygj2nd4 1540 38 . . . cord-009571-mygj2nd4 1541 1 In in IN cord-009571-mygj2nd4 1541 2 summary summary NN cord-009571-mygj2nd4 1541 3 , , , cord-009571-mygj2nd4 1541 4 of of IN cord-009571-mygj2nd4 1541 5 50 50 CD cord-009571-mygj2nd4 1541 6 patients patient NNS cord-009571-mygj2nd4 1541 7 screened screen VBN cord-009571-mygj2nd4 1541 8 , , , cord-009571-mygj2nd4 1541 9 13 13 CD cord-009571-mygj2nd4 1541 10 had have VBD cord-009571-mygj2nd4 1541 11 SS SS NNP cord-009571-mygj2nd4 1541 12 as as IN cord-009571-mygj2nd4 1541 13 defined define VBN cord-009571-mygj2nd4 1541 14 above above RB cord-009571-mygj2nd4 1541 15 . . . cord-009571-mygj2nd4 1542 1 Of of IN cord-009571-mygj2nd4 1542 2 these these DT cord-009571-mygj2nd4 1542 3 , , , cord-009571-mygj2nd4 1542 4 12 12 CD cord-009571-mygj2nd4 1542 5 had have VBD cord-009571-mygj2nd4 1542 6 positive positive JJ cord-009571-mygj2nd4 1542 7 Schirmer Schirmer NNP cord-009571-mygj2nd4 1542 8 tests test NNS cord-009571-mygj2nd4 1542 9 , , , cord-009571-mygj2nd4 1542 10 5 5 CD cord-009571-mygj2nd4 1542 11 had have VBD cord-009571-mygj2nd4 1542 12 positive positive JJ cord-009571-mygj2nd4 1542 13 Rose Rose NNP cord-009571-mygj2nd4 1542 14 Bengal Bengal NNP cord-009571-mygj2nd4 1542 15 staining staining NN cord-009571-mygj2nd4 1542 16 , , , cord-009571-mygj2nd4 1542 17 and and CC cord-009571-mygj2nd4 1542 18 3 3 CD cord-009571-mygj2nd4 1542 19 had have VBD cord-009571-mygj2nd4 1542 20 abnormal abnormal JJ cord-009571-mygj2nd4 1542 21 salivary salivary NN cord-009571-mygj2nd4 1542 22 scans scan NNS cord-009571-mygj2nd4 1542 23 . . . cord-009571-mygj2nd4 1543 1 Three three CD cord-009571-mygj2nd4 1543 2 had have VBD cord-009571-mygj2nd4 1543 3 a a DT cord-009571-mygj2nd4 1543 4 positive positive JJ cord-009571-mygj2nd4 1543 5 ANA ANA NNP cord-009571-mygj2nd4 1543 6 , , , cord-009571-mygj2nd4 1543 7 1 1 CD cord-009571-mygj2nd4 1543 8 had have VBD cord-009571-mygj2nd4 1543 9 anti anti JJ cord-009571-mygj2nd4 1543 10 - - JJ cord-009571-mygj2nd4 1543 11 salivary salivary JJ cord-009571-mygj2nd4 1543 12 duct duct NN cord-009571-mygj2nd4 1543 13 antibody antibody NN cord-009571-mygj2nd4 1543 14 , , , cord-009571-mygj2nd4 1543 15 and and CC cord-009571-mygj2nd4 1543 16 3 3 CD cord-009571-mygj2nd4 1543 17 had have VBD cord-009571-mygj2nd4 1543 18 abnormal abnormal JJ cord-009571-mygj2nd4 1543 19 lip lip NN cord-009571-mygj2nd4 1543 20 biopsies biopsy NNS cord-009571-mygj2nd4 1543 21 . . . cord-009571-mygj2nd4 1544 1 Five five CD cord-009571-mygj2nd4 1544 2 had have VBD cord-009571-mygj2nd4 1544 3 musculoskeletal musculoskeletal JJ cord-009571-mygj2nd4 1544 4 complaints complaint NNS cord-009571-mygj2nd4 1544 5 , , , cord-009571-mygj2nd4 1544 6 4 4 CD cord-009571-mygj2nd4 1544 7 had have VBD cord-009571-mygj2nd4 1544 8 Raynaud Raynaud NNP cord-009571-mygj2nd4 1544 9 's 's POS cord-009571-mygj2nd4 1544 10 phenomenon phenomenon NN cord-009571-mygj2nd4 1544 11 , , , cord-009571-mygj2nd4 1544 12 and and CC cord-009571-mygj2nd4 1544 13 2 2 CD cord-009571-mygj2nd4 1544 14 had have VBD cord-009571-mygj2nd4 1544 15 a a DT cord-009571-mygj2nd4 1544 16 concurrent concurrent JJ cord-009571-mygj2nd4 1544 17 diffuse diffuse JJ cord-009571-mygj2nd4 1544 18 connective connective JJ cord-009571-mygj2nd4 1544 19 tissue tissue NN cord-009571-mygj2nd4 1544 20 disease disease NN cord-009571-mygj2nd4 1544 21 . . . cord-009571-mygj2nd4 1545 1 Thus thus RB cord-009571-mygj2nd4 1545 2 , , , cord-009571-mygj2nd4 1545 3 SS SS NNP cord-009571-mygj2nd4 1545 4 in in IN cord-009571-mygj2nd4 1545 5 patients patient NNS cord-009571-mygj2nd4 1545 6 with with IN cord-009571-mygj2nd4 1545 7 non non JJ cord-009571-mygj2nd4 1545 8 - - JJ cord-009571-mygj2nd4 1545 9 Hodgkin Hodgkin NNP cord-009571-mygj2nd4 1545 10 's 's POS cord-009571-mygj2nd4 1545 11 lymphoma lymphoma NN cord-009571-mygj2nd4 1545 12 appears appear VBZ cord-009571-mygj2nd4 1545 13 to to TO cord-009571-mygj2nd4 1545 14 be be VB cord-009571-mygj2nd4 1545 15 more more RBR cord-009571-mygj2nd4 1545 16 common common JJ cord-009571-mygj2nd4 1545 17 than than IN cord-009571-mygj2nd4 1545 18 is be VBZ cord-009571-mygj2nd4 1545 19 generally generally RB cord-009571-mygj2nd4 1545 20 appreciated appreciate VBN cord-009571-mygj2nd4 1545 21 . . . cord-009571-mygj2nd4 1546 1 Hydroxyapatite Hydroxyapatite NNP cord-009571-mygj2nd4 1546 2 crystals crystal NNS cord-009571-mygj2nd4 1546 3 have have VBP cord-009571-mygj2nd4 1546 4 been be VBN cord-009571-mygj2nd4 1546 5 recently recently RB cord-009571-mygj2nd4 1546 6 suggested suggest VBN cord-009571-mygj2nd4 1546 7 as as IN cord-009571-mygj2nd4 1546 8 a a DT cord-009571-mygj2nd4 1546 9 cause cause NN cord-009571-mygj2nd4 1546 10 of of IN cord-009571-mygj2nd4 1546 11 crystal crystal NN cord-009571-mygj2nd4 1546 12 induced induce VBN cord-009571-mygj2nd4 1546 13 synovitis synovitis NNP cord-009571-mygj2nd4 1546 14 in in IN cord-009571-mygj2nd4 1546 15 humans human NNS cord-009571-mygj2nd4 1546 16 . . . cord-009571-mygj2nd4 1547 1 We -PRON- PRP cord-009571-mygj2nd4 1547 2 have have VBP cord-009571-mygj2nd4 1547 3 performed perform VBN cord-009571-mygj2nd4 1547 4 the the DT cord-009571-mygj2nd4 1547 5 following follow VBG cord-009571-mygj2nd4 1547 6 studies study NNS cord-009571-mygj2nd4 1547 7 in in IN cord-009571-mygj2nd4 1547 8 an an DT cord-009571-mygj2nd4 1547 9 attempt attempt NN cord-009571-mygj2nd4 1547 10 to to TO cord-009571-mygj2nd4 1547 11 develop develop VB cord-009571-mygj2nd4 1547 12 an an DT cord-009571-mygj2nd4 1547 13 experimental experimental JJ cord-009571-mygj2nd4 1547 14 model model NN cord-009571-mygj2nd4 1547 15 to to TO cord-009571-mygj2nd4 1547 16 further further RB cord-009571-mygj2nd4 1547 17 study study VB cord-009571-mygj2nd4 1547 18 the the DT cord-009571-mygj2nd4 1547 19 relation relation NN cord-009571-mygj2nd4 1547 20 of of IN cord-009571-mygj2nd4 1547 21 hydroxyapatite hydroxyapatite NN cord-009571-mygj2nd4 1547 22 to to IN cord-009571-mygj2nd4 1547 23 inflammation inflammation NN cord-009571-mygj2nd4 1547 24 . . . cord-009571-mygj2nd4 1548 1 Articular articular JJ cord-009571-mygj2nd4 1548 2 calcification calcification NN cord-009571-mygj2nd4 1548 3 was be VBD cord-009571-mygj2nd4 1548 4 induced induce VBN cord-009571-mygj2nd4 1548 5 in in IN cord-009571-mygj2nd4 1548 6 six six CD cord-009571-mygj2nd4 1548 7 - - HYPH cord-009571-mygj2nd4 1548 8 week week NN cord-009571-mygj2nd4 1548 9 - - HYPH cord-009571-mygj2nd4 1548 10 old old JJ cord-009571-mygj2nd4 1548 11 NZW NZW NNP cord-009571-mygj2nd4 1548 12 rabbits rabbit NNS cord-009571-mygj2nd4 1548 13 with with IN cord-009571-mygj2nd4 1548 14 techniques technique NNS cord-009571-mygj2nd4 1548 15 similar similar JJ cord-009571-mygj2nd4 1548 16 to to IN cord-009571-mygj2nd4 1548 17 those those DT cord-009571-mygj2nd4 1548 18 described describe VBN cord-009571-mygj2nd4 1548 19 by by IN cord-009571-mygj2nd4 1548 20 Selye Selye NNP cord-009571-mygj2nd4 1548 21 in in IN cord-009571-mygj2nd4 1548 22 other other JJ cord-009571-mygj2nd4 1548 23 tissues tissue NNS cord-009571-mygj2nd4 1548 24 . . . cord-009571-mygj2nd4 1549 1 Eight eight CD cord-009571-mygj2nd4 1549 2 rabbits rabbit NNS cord-009571-mygj2nd4 1549 3 were be VBD cord-009571-mygj2nd4 1549 4 given give VBN cord-009571-mygj2nd4 1549 5 a a DT cord-009571-mygj2nd4 1549 6 single single JJ cord-009571-mygj2nd4 1549 7 dose dose NN cord-009571-mygj2nd4 1549 8 of of IN cord-009571-mygj2nd4 1549 9 500,000 500,000 CD cord-009571-mygj2nd4 1549 10 U u NN cord-009571-mygj2nd4 1549 11 oral oral JJ cord-009571-mygj2nd4 1549 12 vitamin vitamin NN cord-009571-mygj2nd4 1549 13 D d NN cord-009571-mygj2nd4 1549 14 , , , cord-009571-mygj2nd4 1549 15 and and CC cord-009571-mygj2nd4 1549 16 the the DT cord-009571-mygj2nd4 1549 17 next next JJ cord-009571-mygj2nd4 1549 18 day day NN cord-009571-mygj2nd4 1549 19 left leave VBD cord-009571-mygj2nd4 1549 20 knees knee NNS cord-009571-mygj2nd4 1549 21 were be VBD cord-009571-mygj2nd4 1549 22 injected inject VBN cord-009571-mygj2nd4 1549 23 with with IN cord-009571-mygj2nd4 1549 24 I -PRON- PRP cord-009571-mygj2nd4 1549 25 mg mg NNP cord-009571-mygj2nd4 1549 26 FeCI FeCI NNP cord-009571-mygj2nd4 1549 27 , , , cord-009571-mygj2nd4 1549 28 . . . cord-009571-mygj2nd4 1550 1 Right right JJ cord-009571-mygj2nd4 1550 2 knees knee NNS cord-009571-mygj2nd4 1550 3 were be VBD cord-009571-mygj2nd4 1550 4 injected inject VBN cord-009571-mygj2nd4 1550 5 with with IN cord-009571-mygj2nd4 1550 6 saline saline NN cord-009571-mygj2nd4 1550 7 . . . cord-009571-mygj2nd4 1551 1 Four four CD cord-009571-mygj2nd4 1551 2 rabbits rabbit NNS cord-009571-mygj2nd4 1551 3 received receive VBD cord-009571-mygj2nd4 1551 4 intraarticular intraarticular NNP cord-009571-mygj2nd4 1551 5 FeCI FeCI NNP cord-009571-mygj2nd4 1551 6 , , , cord-009571-mygj2nd4 1551 7 without without IN cord-009571-mygj2nd4 1551 8 vita vita NNP cord-009571-mygj2nd4 1551 9 - - HYPH cord-009571-mygj2nd4 1551 10 min min NNP cord-009571-mygj2nd4 1551 11 D. D. NNP cord-009571-mygj2nd4 1551 12 Cartilage Cartilage NNP cord-009571-mygj2nd4 1551 13 and and CC cord-009571-mygj2nd4 1551 14 synovial synovial JJ cord-009571-mygj2nd4 1551 15 membrane membrane NN cord-009571-mygj2nd4 1551 16 were be VBD cord-009571-mygj2nd4 1551 17 studied study VBN cord-009571-mygj2nd4 1551 18 by by IN cord-009571-mygj2nd4 1551 19 light light NN cord-009571-mygj2nd4 1551 20 and and CC cord-009571-mygj2nd4 1551 21 electron electron NN cord-009571-mygj2nd4 1551 22 microscopy microscopy NN cord-009571-mygj2nd4 1551 23 at at IN cord-009571-mygj2nd4 1551 24 5 5 CD cord-009571-mygj2nd4 1551 25 , , , cord-009571-mygj2nd4 1551 26 15 15 CD cord-009571-mygj2nd4 1551 27 , , , cord-009571-mygj2nd4 1551 28 and and CC cord-009571-mygj2nd4 1551 29 45 45 CD cord-009571-mygj2nd4 1551 30 days day NNS cord-009571-mygj2nd4 1551 31 . . . cord-009571-mygj2nd4 1552 1 Synovianalysis Synovianalysis NNP cord-009571-mygj2nd4 1552 2 , , , cord-009571-mygj2nd4 1552 3 roentgenograms roentgenogram NNS cord-009571-mygj2nd4 1552 4 , , , cord-009571-mygj2nd4 1552 5 and and CC cord-009571-mygj2nd4 1552 6 microradiography microradiography NN cord-009571-mygj2nd4 1552 7 were be VBD cord-009571-mygj2nd4 1552 8 also also RB cord-009571-mygj2nd4 1552 9 done do VBN cord-009571-mygj2nd4 1552 10 . . . cord-009571-mygj2nd4 1553 1 Six six CD cord-009571-mygj2nd4 1553 2 other other JJ cord-009571-mygj2nd4 1553 3 six six CD cord-009571-mygj2nd4 1553 4 - - HYPH cord-009571-mygj2nd4 1553 5 week week NN cord-009571-mygj2nd4 1553 6 - - HYPH cord-009571-mygj2nd4 1553 7 old old JJ cord-009571-mygj2nd4 1553 8 rabbits rabbit NNS cord-009571-mygj2nd4 1553 9 were be VBD cord-009571-mygj2nd4 1553 10 given give VBN cord-009571-mygj2nd4 1553 11 vitamin vitamin NN cord-009571-mygj2nd4 1553 12 D d NN cord-009571-mygj2nd4 1553 13 orally orally RB cord-009571-mygj2nd4 1553 14 500,000 500,000 CD cord-009571-mygj2nd4 1553 15 U u NN cord-009571-mygj2nd4 1553 16 for for IN cord-009571-mygj2nd4 1553 17 90 90 CD cord-009571-mygj2nd4 1553 18 days day NNS cord-009571-mygj2nd4 1553 19 without without IN cord-009571-mygj2nd4 1553 20 any any DT cord-009571-mygj2nd4 1553 21 intraarticular intraarticular JJ cord-009571-mygj2nd4 1553 22 injection injection NN cord-009571-mygj2nd4 1553 23 . . . cord-009571-mygj2nd4 1554 1 Six six CD cord-009571-mygj2nd4 1554 2 controls control NNS cord-009571-mygj2nd4 1554 3 were be VBD cord-009571-mygj2nd4 1554 4 followed follow VBN cord-009571-mygj2nd4 1554 5 without without IN cord-009571-mygj2nd4 1554 6 vitamin vitamin NN cord-009571-mygj2nd4 1554 7 D d NN cord-009571-mygj2nd4 1554 8 and and CC cord-009571-mygj2nd4 1554 9 all all DT cord-009571-mygj2nd4 1554 10 were be VBD cord-009571-mygj2nd4 1554 11 killed kill VBN cord-009571-mygj2nd4 1554 12 at at IN cord-009571-mygj2nd4 1554 13 90 90 CD cord-009571-mygj2nd4 1554 14 days day NNS cord-009571-mygj2nd4 1554 15 for for IN cord-009571-mygj2nd4 1554 16 studies study NNS cord-009571-mygj2nd4 1554 17 as as IN cord-009571-mygj2nd4 1554 18 above above RB cord-009571-mygj2nd4 1554 19 . . . cord-009571-mygj2nd4 1555 1 Mild mild JJ cord-009571-mygj2nd4 1555 2 synovial synovial JJ cord-009571-mygj2nd4 1555 3 inflammation inflammation NN cord-009571-mygj2nd4 1555 4 was be VBD cord-009571-mygj2nd4 1555 5 seen see VBN cord-009571-mygj2nd4 1555 6 in in IN cord-009571-mygj2nd4 1555 7 FeCI FeCI NNP cord-009571-mygj2nd4 1555 8 , , , cord-009571-mygj2nd4 1555 9 injected inject VBD cord-009571-mygj2nd4 1555 10 joints joint NNS cord-009571-mygj2nd4 1555 11 without without IN cord-009571-mygj2nd4 1555 12 vitamin vitamin NN cord-009571-mygj2nd4 1555 13 D. D. NNP cord-009571-mygj2nd4 1556 1 In in IN cord-009571-mygj2nd4 1556 2 rabbits rabbit NNS cord-009571-mygj2nd4 1556 3 given give VBN cord-009571-mygj2nd4 1556 4 vitamin vitamin NN cord-009571-mygj2nd4 1556 5 D d NN cord-009571-mygj2nd4 1556 6 there there EX cord-009571-mygj2nd4 1556 7 was be VBD cord-009571-mygj2nd4 1556 8 tissue tissue NN cord-009571-mygj2nd4 1556 9 necrosis necrosis NN cord-009571-mygj2nd4 1556 10 in in IN cord-009571-mygj2nd4 1556 11 the the DT cord-009571-mygj2nd4 1556 12 FeCI feci NN cord-009571-mygj2nd4 1556 13 , , , cord-009571-mygj2nd4 1556 14 injected inject VBD cord-009571-mygj2nd4 1556 15 joint joint NN cord-009571-mygj2nd4 1556 16 with with IN cord-009571-mygj2nd4 1556 17 synovial synovial JJ cord-009571-mygj2nd4 1556 18 calcification calcification NN cord-009571-mygj2nd4 1556 19 visible visible JJ cord-009571-mygj2nd4 1556 20 by by IN cord-009571-mygj2nd4 1556 21 light light JJ cord-009571-mygj2nd4 1556 22 microscopy microscopy NNS cord-009571-mygj2nd4 1556 23 by by IN cord-009571-mygj2nd4 1556 24 the the DT cord-009571-mygj2nd4 1556 25 fifth fifth JJ cord-009571-mygj2nd4 1556 26 day day NN cord-009571-mygj2nd4 1556 27 . . . cord-009571-mygj2nd4 1557 1 Calcifica Calcifica NNP cord-009571-mygj2nd4 1557 2 - - HYPH cord-009571-mygj2nd4 1557 3 tions tion NNS cord-009571-mygj2nd4 1557 4 were be VBD cord-009571-mygj2nd4 1557 5 all all DT cord-009571-mygj2nd4 1557 6 characteristic characteristic JJ cord-009571-mygj2nd4 1557 7 of of IN cord-009571-mygj2nd4 1557 8 hydroxyapatite hydroxyapatite NN cord-009571-mygj2nd4 1557 9 by by IN cord-009571-mygj2nd4 1557 10 electron electron NN cord-009571-mygj2nd4 1557 11 microscopy microscopy NNS cord-009571-mygj2nd4 1557 12 and and CC cord-009571-mygj2nd4 1557 13 could could MD cord-009571-mygj2nd4 1557 14 be be VB cord-009571-mygj2nd4 1557 15 seen see VBN cord-009571-mygj2nd4 1557 16 in in IN cord-009571-mygj2nd4 1557 17 interstitium interstitium NN cord-009571-mygj2nd4 1557 18 , , , cord-009571-mygj2nd4 1557 19 occasionally occasionally RB cord-009571-mygj2nd4 1557 20 on on IN cord-009571-mygj2nd4 1557 21 collagen collagen NN cord-009571-mygj2nd4 1557 22 fibers fiber NNS cord-009571-mygj2nd4 1557 23 , , , cord-009571-mygj2nd4 1557 24 and and CC cord-009571-mygj2nd4 1557 25 in in IN cord-009571-mygj2nd4 1557 26 vacuoles vacuole NNS cord-009571-mygj2nd4 1557 27 of of IN cord-009571-mygj2nd4 1557 28 synovial synovial JJ cord-009571-mygj2nd4 1557 29 cells cell NNS cord-009571-mygj2nd4 1557 30 . . . cord-009571-mygj2nd4 1558 1 Small small JJ cord-009571-mygj2nd4 1558 2 amounts amount NNS cord-009571-mygj2nd4 1558 3 of of IN cord-009571-mygj2nd4 1558 4 iron iron NN cord-009571-mygj2nd4 1558 5 were be VBD cord-009571-mygj2nd4 1558 6 seen see VBN cord-009571-mygj2nd4 1558 7 in in IN cord-009571-mygj2nd4 1558 8 phagocytes phagocyte NNS cord-009571-mygj2nd4 1558 9 without without IN cord-009571-mygj2nd4 1558 10 relation relation NN cord-009571-mygj2nd4 1558 11 to to IN cord-009571-mygj2nd4 1558 12 the the DT cord-009571-mygj2nd4 1558 13 calcification calcification NN cord-009571-mygj2nd4 1558 14 . . . cord-009571-mygj2nd4 1559 1 Calcification calcification NN cord-009571-mygj2nd4 1559 2 increased increase VBD cord-009571-mygj2nd4 1559 3 over over IN cord-009571-mygj2nd4 1559 4 45 45 CD cord-009571-mygj2nd4 1559 5 days day NNS cord-009571-mygj2nd4 1559 6 . . . cord-009571-mygj2nd4 1560 1 Cartilage cartilage NN cord-009571-mygj2nd4 1560 2 was be VBD cord-009571-mygj2nd4 1560 3 not not RB cord-009571-mygj2nd4 1560 4 calcified calcified JJ cord-009571-mygj2nd4 1560 5 except except IN cord-009571-mygj2nd4 1560 6 for for IN cord-009571-mygj2nd4 1560 7 a a DT cord-009571-mygj2nd4 1560 8 small small JJ cord-009571-mygj2nd4 1560 9 surface surface NN cord-009571-mygj2nd4 1560 10 deposit deposit NN cord-009571-mygj2nd4 1560 11 at at IN cord-009571-mygj2nd4 1560 12 45 45 CD cord-009571-mygj2nd4 1560 13 days day NNS cord-009571-mygj2nd4 1560 14 in in IN cord-009571-mygj2nd4 1560 15 one one CD cord-009571-mygj2nd4 1560 16 rabbit rabbit NN cord-009571-mygj2nd4 1560 17 . . . cord-009571-mygj2nd4 1561 1 Synovial synovial JJ cord-009571-mygj2nd4 1561 2 fluids fluid NNS cord-009571-mygj2nd4 1561 3 had have VBD cord-009571-mygj2nd4 1561 4 only only RB cord-009571-mygj2nd4 1561 5 very very RB cord-009571-mygj2nd4 1561 6 low low JJ cord-009571-mygj2nd4 1561 7 leukocyte leukocyte NN cord-009571-mygj2nd4 1561 8 counts count VBZ cord-009571-mygj2nd4 1561 9 with with IN cord-009571-mygj2nd4 1561 10 predominance predominance NN cord-009571-mygj2nd4 1561 11 of of IN cord-009571-mygj2nd4 1561 12 mononuclear mononuclear JJ cord-009571-mygj2nd4 1561 13 cells cell NNS cord-009571-mygj2nd4 1561 14 . . . cord-009571-mygj2nd4 1562 1 Joints joint NNS cord-009571-mygj2nd4 1562 2 not not RB cord-009571-mygj2nd4 1562 3 injected inject VBN cord-009571-mygj2nd4 1562 4 with with IN cord-009571-mygj2nd4 1562 5 iron iron NN cord-009571-mygj2nd4 1562 6 were be VBD cord-009571-mygj2nd4 1562 7 normal normal JJ cord-009571-mygj2nd4 1562 8 . . . cord-009571-mygj2nd4 1563 1 The the DT cord-009571-mygj2nd4 1563 2 rabbits rabbit NNS cord-009571-mygj2nd4 1563 3 given give VBN cord-009571-mygj2nd4 1563 4 vitamin vitamin NN cord-009571-mygj2nd4 1563 5 D d NN cord-009571-mygj2nd4 1563 6 for for IN cord-009571-mygj2nd4 1563 7 90 90 CD cord-009571-mygj2nd4 1563 8 days day NNS cord-009571-mygj2nd4 1563 9 all all DT cord-009571-mygj2nd4 1563 10 developed develop VBD cord-009571-mygj2nd4 1563 11 round round JJ cord-009571-mygj2nd4 1563 12 , , , cord-009571-mygj2nd4 1563 13 mid mid JJ cord-009571-mygj2nd4 1563 14 - - JJ cord-009571-mygj2nd4 1563 15 zone zone JJ cord-009571-mygj2nd4 1563 16 articular articular JJ cord-009571-mygj2nd4 1563 17 cartilage cartilage NN cord-009571-mygj2nd4 1563 18 calcifications calcification NNS cord-009571-mygj2nd4 1563 19 similar similar JJ cord-009571-mygj2nd4 1563 20 to to IN cord-009571-mygj2nd4 1563 21 those those DT cord-009571-mygj2nd4 1563 22 spontaneously spontaneously RB cord-009571-mygj2nd4 1563 23 occurring occur VBG cord-009571-mygj2nd4 1563 24 in in IN cord-009571-mygj2nd4 1563 25 older old JJR cord-009571-mygj2nd4 1563 26 rabbits rabbit NNS cord-009571-mygj2nd4 1563 27 . . . cord-009571-mygj2nd4 1564 1 There there EX cord-009571-mygj2nd4 1564 2 was be VBD cord-009571-mygj2nd4 1564 3 no no DT cord-009571-mygj2nd4 1564 4 synovial synovial JJ cord-009571-mygj2nd4 1564 5 calcification calcification NN cord-009571-mygj2nd4 1564 6 , , , cord-009571-mygj2nd4 1564 7 inflammation inflammation NN cord-009571-mygj2nd4 1564 8 , , , cord-009571-mygj2nd4 1564 9 or or CC cord-009571-mygj2nd4 1564 10 joint joint JJ cord-009571-mygj2nd4 1564 11 effusion effusion NN cord-009571-mygj2nd4 1564 12 . . . cord-009571-mygj2nd4 1565 1 By by IN cord-009571-mygj2nd4 1565 2 electronmicroscopy electronmicroscopy NN cord-009571-mygj2nd4 1565 3 all all DT cord-009571-mygj2nd4 1565 4 calcium calcium NN cord-009571-mygj2nd4 1565 5 deposits deposit NNS cord-009571-mygj2nd4 1565 6 were be VBD cord-009571-mygj2nd4 1565 7 in in IN cord-009571-mygj2nd4 1565 8 the the DT cord-009571-mygj2nd4 1565 9 interstitium interstitium NN cord-009571-mygj2nd4 1565 10 and and CC cord-009571-mygj2nd4 1565 11 were be VBD cord-009571-mygj2nd4 1565 12 hydroxyapatite hydroxyapatite JJ cord-009571-mygj2nd4 1565 13 - - HYPH cord-009571-mygj2nd4 1565 14 like like JJ cord-009571-mygj2nd4 1565 15 needles needle NNS cord-009571-mygj2nd4 1565 16 . . . cord-009571-mygj2nd4 1566 1 Many many JJ cord-009571-mygj2nd4 1566 2 chondrocytes chondrocyte NNS cord-009571-mygj2nd4 1566 3 showed show VBD cord-009571-mygj2nd4 1566 4 degenerative degenerative JJ cord-009571-mygj2nd4 1566 5 changes change NNS cord-009571-mygj2nd4 1566 6 . . . cord-009571-mygj2nd4 1567 1 Thus thus RB cord-009571-mygj2nd4 1567 2 , , , cord-009571-mygj2nd4 1567 3 different different JJ cord-009571-mygj2nd4 1567 4 patterns pattern NNS cord-009571-mygj2nd4 1567 5 of of IN cord-009571-mygj2nd4 1567 6 articular articular JJ cord-009571-mygj2nd4 1567 7 calcification calcification NN cord-009571-mygj2nd4 1567 8 can can MD cord-009571-mygj2nd4 1567 9 be be VB cord-009571-mygj2nd4 1567 10 produced produce VBN cord-009571-mygj2nd4 1567 11 in in IN cord-009571-mygj2nd4 1567 12 rabbits rabbit NNS cord-009571-mygj2nd4 1567 13 ' ' POS cord-009571-mygj2nd4 1567 14 knees knee NNS cord-009571-mygj2nd4 1567 15 with with IN cord-009571-mygj2nd4 1567 16 techniques technique NNS cord-009571-mygj2nd4 1567 17 described describe VBN cord-009571-mygj2nd4 1567 18 . . . cord-009571-mygj2nd4 1568 1 Acute acute JJ cord-009571-mygj2nd4 1568 2 crystal crystal NN cord-009571-mygj2nd4 1569 1 associated associated JJ cord-009571-mygj2nd4 1569 2 inflammation inflammation NN cord-009571-mygj2nd4 1569 3 was be VBD cord-009571-mygj2nd4 1569 4 not not RB cord-009571-mygj2nd4 1569 5 demonstrated demonstrate VBN cord-009571-mygj2nd4 1569 6 . . . cord-009571-mygj2nd4 1570 1 Crystals crystal NNS cord-009571-mygj2nd4 1570 2 formed form VBD cord-009571-mygj2nd4 1570 3 and and CC cord-009571-mygj2nd4 1570 4 sequestered sequester VBN cord-009571-mygj2nd4 1570 5 in in IN cord-009571-mygj2nd4 1570 6 synovial synovial JJ cord-009571-mygj2nd4 1570 7 or or CC cord-009571-mygj2nd4 1570 8 cartilage cartilage NN cord-009571-mygj2nd4 1570 9 tissue tissue NN cord-009571-mygj2nd4 1570 10 appear appear VBP cord-009571-mygj2nd4 1570 11 to to TO cord-009571-mygj2nd4 1570 12 be be VB cord-009571-mygj2nd4 1570 13 tolerated tolerate VBN cord-009571-mygj2nd4 1570 14 without without IN cord-009571-mygj2nd4 1570 15 inflammation inflammation NN cord-009571-mygj2nd4 1570 16 . . . cord-009571-mygj2nd4 1571 1 Studies study NNS cord-009571-mygj2nd4 1571 2 of of IN cord-009571-mygj2nd4 1571 3 systemic systemic JJ cord-009571-mygj2nd4 1571 4 lupus lupus NN cord-009571-mygj2nd4 1571 5 erythematosus erythematosus NN cord-009571-mygj2nd4 1571 6 ( ( -LRB- cord-009571-mygj2nd4 1571 7 SLE SLE NNP cord-009571-mygj2nd4 1571 8 ) ) -RRB- cord-009571-mygj2nd4 1571 9 families family NNS cord-009571-mygj2nd4 1571 10 and and CC cord-009571-mygj2nd4 1571 11 populations population NNS cord-009571-mygj2nd4 1571 12 suggest suggest VBP cord-009571-mygj2nd4 1571 13 that that IN cord-009571-mygj2nd4 1571 14 a a DT cord-009571-mygj2nd4 1571 15 gene(s gene(s NNP cord-009571-mygj2nd4 1571 16 ) ) -RRB- cord-009571-mygj2nd4 1571 17 linked link VBN cord-009571-mygj2nd4 1571 18 to to IN cord-009571-mygj2nd4 1571 19 the the DT cord-009571-mygj2nd4 1571 20 major major JJ cord-009571-mygj2nd4 1571 21 histocompatibility histocompatibility NN cord-009571-mygj2nd4 1571 22 complex complex NN cord-009571-mygj2nd4 1571 23 ( ( -LRB- cord-009571-mygj2nd4 1571 24 MHC MHC NNP cord-009571-mygj2nd4 1571 25 ) ) -RRB- cord-009571-mygj2nd4 1571 26 influences influence VBZ cord-009571-mygj2nd4 1571 27 SLE SLE NNP cord-009571-mygj2nd4 1571 28 . . . cord-009571-mygj2nd4 1572 1 We -PRON- PRP cord-009571-mygj2nd4 1572 2 have have VBP cord-009571-mygj2nd4 1572 3 examined examine VBN cord-009571-mygj2nd4 1572 4 the the DT cord-009571-mygj2nd4 1572 5 MHC MHC NNP cord-009571-mygj2nd4 1572 6 in in IN cord-009571-mygj2nd4 1572 7 SLE SLE NNP cord-009571-mygj2nd4 1572 8 families family NNS cord-009571-mygj2nd4 1572 9 , , , cord-009571-mygj2nd4 1572 10 patients patient NNS cord-009571-mygj2nd4 1572 11 , , , cord-009571-mygj2nd4 1572 12 and and CC cord-009571-mygj2nd4 1572 13 controls control NNS cord-009571-mygj2nd4 1572 14 by by IN cord-009571-mygj2nd4 1572 15 determining determine VBG cord-009571-mygj2nd4 1572 16 the the DT cord-009571-mygj2nd4 1572 17 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 1572 18 of of IN cord-009571-mygj2nd4 1572 19 antisera antisera NN cord-009571-mygj2nd4 1572 20 which which WDT cord-009571-mygj2nd4 1572 21 detect detect VBP cord-009571-mygj2nd4 1572 22 MHCdetermined mhcdetermine VBN cord-009571-mygj2nd4 1572 23 antigens antigen NNS cord-009571-mygj2nd4 1572 24 expressed express VBN cord-009571-mygj2nd4 1572 25 selectively selectively RB cord-009571-mygj2nd4 1572 26 on on IN cord-009571-mygj2nd4 1572 27 B b NN cord-009571-mygj2nd4 1572 28 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 1572 29 . . . cord-009571-mygj2nd4 1573 1 B b NN cord-009571-mygj2nd4 1573 2 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 1573 3 from from IN cord-009571-mygj2nd4 1573 4 41 41 CD cord-009571-mygj2nd4 1573 5 SLE SLE NNP cord-009571-mygj2nd4 1573 6 patients patient NNS cord-009571-mygj2nd4 1573 7 and and CC cord-009571-mygj2nd4 1573 8 184 184 CD cord-009571-mygj2nd4 1573 9 controls control NNS cord-009571-mygj2nd4 1573 10 were be VBD cord-009571-mygj2nd4 1573 11 tested test VBN cord-009571-mygj2nd4 1573 12 against against IN cord-009571-mygj2nd4 1573 13 a a DT cord-009571-mygj2nd4 1573 14 panel panel NN cord-009571-mygj2nd4 1573 15 of of IN cord-009571-mygj2nd4 1573 16 47 47 CD cord-009571-mygj2nd4 1573 17 pregnancy pregnancy NN cord-009571-mygj2nd4 1573 18 sera sera NNP cord-009571-mygj2nd4 1573 19 , , , cord-009571-mygj2nd4 1573 20 and and CC cord-009571-mygj2nd4 1573 21 reaction reaction NN cord-009571-mygj2nd4 1573 22 frequencies frequency NNS cord-009571-mygj2nd4 1573 23 of of IN cord-009571-mygj2nd4 1573 24 individual individual JJ cord-009571-mygj2nd4 1573 25 sera sera NNP cord-009571-mygj2nd4 1573 26 were be VBD cord-009571-mygj2nd4 1573 27 compared compare VBN cord-009571-mygj2nd4 1573 28 . . . cord-009571-mygj2nd4 1574 1 Twenty twenty CD cord-009571-mygj2nd4 1574 2 - - HYPH cord-009571-mygj2nd4 1574 3 eight eight CD cord-009571-mygj2nd4 1574 4 of of IN cord-009571-mygj2nd4 1574 5 the the DT cord-009571-mygj2nd4 1574 6 SLE SLE NNP cord-009571-mygj2nd4 1574 7 patients patient NNS cord-009571-mygj2nd4 1574 8 were be VBD cord-009571-mygj2nd4 1574 9 also also RB cord-009571-mygj2nd4 1574 10 typed type VBN cord-009571-mygj2nd4 1574 11 with with IN cord-009571-mygj2nd4 1574 12 a a DT cord-009571-mygj2nd4 1574 13 panel panel NN cord-009571-mygj2nd4 1574 14 of of IN cord-009571-mygj2nd4 1574 15 HLA HLA NNP cord-009571-mygj2nd4 1574 16 - - HYPH cord-009571-mygj2nd4 1574 17 Drelated Drelated NNP cord-009571-mygj2nd4 1574 18 sera sera NNP cord-009571-mygj2nd4 1574 19 from from IN cord-009571-mygj2nd4 1574 20 the the DT cord-009571-mygj2nd4 1574 21 7th 7th JJ cord-009571-mygj2nd4 1574 22 International International NNP cord-009571-mygj2nd4 1574 23 Histocompatibility Histocompatibility NNP cord-009571-mygj2nd4 1574 24 Workshop Workshop NNP cord-009571-mygj2nd4 1574 25 , , , cord-009571-mygj2nd4 1574 26 HLA HLA NNP cord-009571-mygj2nd4 1574 27 - - HYPH cord-009571-mygj2nd4 1574 28 DRw DRw NNS cord-009571-mygj2nd4 1574 29 types type NNS cord-009571-mygj2nd4 1574 30 assigned assign VBN cord-009571-mygj2nd4 1574 31 , , , cord-009571-mygj2nd4 1574 32 and and CC cord-009571-mygj2nd4 1574 33 compared compare VBN cord-009571-mygj2nd4 1574 34 with with IN cord-009571-mygj2nd4 1574 35 490 490 CD cord-009571-mygj2nd4 1574 36 workshop workshop NN cord-009571-mygj2nd4 1574 37 controls control NNS cord-009571-mygj2nd4 1574 38 . . . cord-009571-mygj2nd4 1575 1 The the DT cord-009571-mygj2nd4 1575 2 HLA HLA NNP cord-009571-mygj2nd4 1575 3 - - HYPH cord-009571-mygj2nd4 1575 4 DRw DRw NNS cord-009571-mygj2nd4 1575 5 types type NNS cord-009571-mygj2nd4 1575 6 and and CC cord-009571-mygj2nd4 1575 7 individual individual JJ cord-009571-mygj2nd4 1575 8 serum serum NN cord-009571-mygj2nd4 1575 9 reactivities reactivity NNS cord-009571-mygj2nd4 1575 10 which which WDT cord-009571-mygj2nd4 1575 11 were be VBD cord-009571-mygj2nd4 1575 12 increased increase VBN cord-009571-mygj2nd4 1575 13 in in IN cord-009571-mygj2nd4 1575 14 the the DT cord-009571-mygj2nd4 1575 15 SLE SLE NNP cord-009571-mygj2nd4 1575 16 population population NN cord-009571-mygj2nd4 1575 17 are be VBP cord-009571-mygj2nd4 1575 18 shown show VBN cord-009571-mygj2nd4 1575 19 . . . cord-009571-mygj2nd4 1576 1 SLE SLE NNP cord-009571-mygj2nd4 1576 2 families family NNS cord-009571-mygj2nd4 1576 3 shows show VBZ cord-009571-mygj2nd4 1576 4 that that IN cord-009571-mygj2nd4 1576 5 one one CD cord-009571-mygj2nd4 1576 6 HLA HLA NNP cord-009571-mygj2nd4 1576 7 haplotype haplotype NN cord-009571-mygj2nd4 1576 8 is be VBZ cord-009571-mygj2nd4 1576 9 usually usually RB cord-009571-mygj2nd4 1576 10 shared share VBN cord-009571-mygj2nd4 1576 11 among among IN cord-009571-mygj2nd4 1576 12 those those DT cord-009571-mygj2nd4 1576 13 individuals individual NNS cord-009571-mygj2nd4 1576 14 with with IN cord-009571-mygj2nd4 1576 15 SLE SLE NNP cord-009571-mygj2nd4 1576 16 and and CC cord-009571-mygj2nd4 1576 17 other other JJ cord-009571-mygj2nd4 1576 18 autoimmune autoimmune JJ cord-009571-mygj2nd4 1576 19 abnormalities abnormality NNS cord-009571-mygj2nd4 1576 20 in in IN cord-009571-mygj2nd4 1576 21 a a DT cord-009571-mygj2nd4 1576 22 given give VBN cord-009571-mygj2nd4 1576 23 family family NN cord-009571-mygj2nd4 1576 24 . . . cord-009571-mygj2nd4 1577 1 Exceptions exception NNS cord-009571-mygj2nd4 1577 2 exist exist VBP cord-009571-mygj2nd4 1577 3 , , , cord-009571-mygj2nd4 1577 4 however however RB cord-009571-mygj2nd4 1577 5 , , , cord-009571-mygj2nd4 1577 6 indicating indicate VBG cord-009571-mygj2nd4 1577 7 that that IN cord-009571-mygj2nd4 1577 8 the the DT cord-009571-mygj2nd4 1577 9 haplotype haplotype NN cord-009571-mygj2nd4 1577 10 itself -PRON- PRP cord-009571-mygj2nd4 1577 11 is be VBZ cord-009571-mygj2nd4 1577 12 neither neither CC cord-009571-mygj2nd4 1577 13 necessary necessary JJ cord-009571-mygj2nd4 1577 14 nor nor CC cord-009571-mygj2nd4 1577 15 sufficient sufficient JJ cord-009571-mygj2nd4 1577 16 for for IN cord-009571-mygj2nd4 1577 17 the the DT cord-009571-mygj2nd4 1577 18 expression expression NN cord-009571-mygj2nd4 1577 19 of of IN cord-009571-mygj2nd4 1577 20 autoimmunity autoimmunity NN cord-009571-mygj2nd4 1577 21 . . . cord-009571-mygj2nd4 1578 1 This this DT cord-009571-mygj2nd4 1578 2 study study NN cord-009571-mygj2nd4 1578 3 demonstiates demonstiate VBZ cord-009571-mygj2nd4 1578 4 that that IN cord-009571-mygj2nd4 1578 5 certain certain JJ cord-009571-mygj2nd4 1578 6 MHC MHC NNP cord-009571-mygj2nd4 1578 7 - - HYPH cord-009571-mygj2nd4 1578 8 related relate VBN cord-009571-mygj2nd4 1578 9 Bcell Bcell NNP cord-009571-mygj2nd4 1578 10 alloantigens alloantigen NNS cord-009571-mygj2nd4 1578 11 , , , cord-009571-mygj2nd4 1578 12 possibly possibly RB cord-009571-mygj2nd4 1578 13 products product NNS cord-009571-mygj2nd4 1578 14 of of IN cord-009571-mygj2nd4 1578 15 immune immune JJ cord-009571-mygj2nd4 1578 16 response response NN cord-009571-mygj2nd4 1578 17 genes gene NNS cord-009571-mygj2nd4 1578 18 , , , cord-009571-mygj2nd4 1578 19 are be VBP cord-009571-mygj2nd4 1578 20 increased increase VBN cord-009571-mygj2nd4 1578 21 in in IN cord-009571-mygj2nd4 1578 22 SLE SLE NNP cord-009571-mygj2nd4 1578 23 . . . cord-009571-mygj2nd4 1579 1 Family family NN cord-009571-mygj2nd4 1579 2 study study NN cord-009571-mygj2nd4 1579 3 indicates indicate VBZ cord-009571-mygj2nd4 1579 4 that that IN cord-009571-mygj2nd4 1579 5 the the DT cord-009571-mygj2nd4 1579 6 requirements requirement NNS cord-009571-mygj2nd4 1579 7 for for IN cord-009571-mygj2nd4 1579 8 SLE SLE NNP cord-009571-mygj2nd4 1579 9 development development NN cord-009571-mygj2nd4 1579 10 are be VBP cord-009571-mygj2nd4 1579 11 not not RB cord-009571-mygj2nd4 1579 12 limited limited JJ cord-009571-mygj2nd4 1579 13 t t NN cord-009571-mygj2nd4 1579 14 o o NN cord-009571-mygj2nd4 1579 15 the the DT cord-009571-mygj2nd4 1579 16 MHC MHC NNP cord-009571-mygj2nd4 1579 17 , , , cord-009571-mygj2nd4 1579 18 however however RB cord-009571-mygj2nd4 1579 19 , , , cord-009571-mygj2nd4 1579 20 and and CC cord-009571-mygj2nd4 1579 21 probably probably RB cord-009571-mygj2nd4 1579 22 involve involve VBP cord-009571-mygj2nd4 1579 23 additional additional JJ cord-009571-mygj2nd4 1579 24 genetic genetic JJ cord-009571-mygj2nd4 1579 25 and/or and/or CC cord-009571-mygj2nd4 1579 26 environmental environmental JJ cord-009571-mygj2nd4 1579 27 factors factor NNS cord-009571-mygj2nd4 1579 28 . . . cord-009571-mygj2nd4 1579 29 _SP cord-009571-mygj2nd4 1580 1 Clinical clinical JJ cord-009571-mygj2nd4 1580 2 observations observation NNS cord-009571-mygj2nd4 1580 3 of of IN cord-009571-mygj2nd4 1580 4 increased increase VBN cord-009571-mygj2nd4 1580 5 osteoarthritis osteoarthritis NN cord-009571-mygj2nd4 1580 6 ( ( -LRB- cord-009571-mygj2nd4 1580 7 OA OA NNP cord-009571-mygj2nd4 1580 8 ) ) -RRB- cord-009571-mygj2nd4 1580 9 with with IN cord-009571-mygj2nd4 1580 10 menopause menopause NN cord-009571-mygj2nd4 1580 11 and and CC cord-009571-mygj2nd4 1580 12 studies study NNS cord-009571-mygj2nd4 1580 13 of of IN cord-009571-mygj2nd4 1580 14 OA OA NNP cord-009571-mygj2nd4 1580 15 in in IN cord-009571-mygj2nd4 1580 16 experimental experimental JJ cord-009571-mygj2nd4 1580 17 animals animal NNS cord-009571-mygj2nd4 1580 18 suggest suggest VBP cord-009571-mygj2nd4 1580 19 that that IN cord-009571-mygj2nd4 1580 20 androgens androgen NNS cord-009571-mygj2nd4 1580 21 worsen worsen NN cord-009571-mygj2nd4 1580 22 and and CC cord-009571-mygj2nd4 1580 23 estrogens estrogen NNS cord-009571-mygj2nd4 1580 24 ameliorate ameliorate VBP cord-009571-mygj2nd4 1580 25 OA OA NNP cord-009571-mygj2nd4 1580 26 . . . cord-009571-mygj2nd4 1581 1 Further further JJ cord-009571-mygj2nd4 1581 2 studies study NNS cord-009571-mygj2nd4 1581 3 have have VBP cord-009571-mygj2nd4 1581 4 demonstrated demonstrate VBN cord-009571-mygj2nd4 1581 5 that that IN cord-009571-mygj2nd4 1581 6 estrogens estrogen NNS cord-009571-mygj2nd4 1581 7 suppress suppress VBP cord-009571-mygj2nd4 1581 8 and and CC cord-009571-mygj2nd4 1581 9 androgens androgen NNS cord-009571-mygj2nd4 1581 10 increase increase VBP cord-009571-mygj2nd4 1581 11 35s04 35s04 CD cord-009571-mygj2nd4 1581 12 incorporation incorporation NN cord-009571-mygj2nd4 1581 13 into into IN cord-009571-mygj2nd4 1581 14 nonarticular nonarticular NNP cord-009571-mygj2nd4 1581 15 cartilage cartilage NNP cord-009571-mygj2nd4 1581 16 . . . cord-009571-mygj2nd4 1582 1 Using use VBG cord-009571-mygj2nd4 1582 2 a a DT cord-009571-mygj2nd4 1582 3 rabbit rabbit NN cord-009571-mygj2nd4 1582 4 partial partial JJ cord-009571-mygj2nd4 1582 5 meniscectomy meniscectomy NN cord-009571-mygj2nd4 1582 6 model model NN cord-009571-mygj2nd4 1582 7 of of IN cord-009571-mygj2nd4 1582 8 experimentally experimentally RB cord-009571-mygj2nd4 1582 9 induced induce VBN cord-009571-mygj2nd4 1582 10 OA OA NNP cord-009571-mygj2nd4 1582 11 , , , cord-009571-mygj2nd4 1582 12 we -PRON- PRP cord-009571-mygj2nd4 1582 13 compared compare VBD cord-009571-mygj2nd4 1582 14 nontreatment nontreatment NN cord-009571-mygj2nd4 1582 15 ( ( -LRB- cord-009571-mygj2nd4 1582 16 18 18 CD cord-009571-mygj2nd4 1582 17 rabbits rabbit NNS cord-009571-mygj2nd4 1582 18 ) ) -RRB- cord-009571-mygj2nd4 1582 19 , , , cord-009571-mygj2nd4 1582 20 estradiol estradiol FW cord-009571-mygj2nd4 1582 21 valerate valerate NNP cord-009571-mygj2nd4 1582 22 1.6 1.6 CD cord-009571-mygj2nd4 1583 1 mg mg NNP cord-009571-mygj2nd4 1583 2 / / SYM cord-009571-mygj2nd4 1583 3 kg kg NNP cord-009571-mygj2nd4 1583 4 intramuscularly intramuscularly RB cord-009571-mygj2nd4 1583 5 every every DT cord-009571-mygj2nd4 1583 6 2 2 CD cord-009571-mygj2nd4 1583 7 weeks week NNS cord-009571-mygj2nd4 1583 8 ( ( -LRB- cord-009571-mygj2nd4 1583 9 20 20 CD cord-009571-mygj2nd4 1583 10 rabbits rabbit NNS cord-009571-mygj2nd4 1583 11 ) ) -RRB- cord-009571-mygj2nd4 1583 12 , , , cord-009571-mygj2nd4 1583 13 and and CC cord-009571-mygj2nd4 1583 14 testosterone testosterone NN cord-009571-mygj2nd4 1583 15 cypionate cypionate NN cord-009571-mygj2nd4 1584 1 5 5 CD cord-009571-mygj2nd4 1584 2 mg mg NNP cord-009571-mygj2nd4 1584 3 / / SYM cord-009571-mygj2nd4 1584 4 kg kg NNS cord-009571-mygj2nd4 1584 5 intramuscularly intramuscularly RB cord-009571-mygj2nd4 1584 6 every every DT cord-009571-mygj2nd4 1584 7 2 2 CD cord-009571-mygj2nd4 1584 8 weeks week NNS cord-009571-mygj2nd4 1584 9 ( ( -LRB- cord-009571-mygj2nd4 1584 10 20 20 CD cord-009571-mygj2nd4 1584 11 rabbits rabbit NNS cord-009571-mygj2nd4 1584 12 ) ) -RRB- cord-009571-mygj2nd4 1585 1 on on IN cord-009571-mygj2nd4 1585 2 the the DT cord-009571-mygj2nd4 1585 3 development development NN cord-009571-mygj2nd4 1585 4 of of IN cord-009571-mygj2nd4 1585 5 OA OA NNP cord-009571-mygj2nd4 1585 6 and and CC cord-009571-mygj2nd4 1585 7 on on IN cord-009571-mygj2nd4 1585 8 proteoglycan proteoglycan NN cord-009571-mygj2nd4 1585 9 ( ( -LRB- cord-009571-mygj2nd4 1585 10 PG pg NN cord-009571-mygj2nd4 1585 11 ) ) -RRB- cord-009571-mygj2nd4 1585 12 synthesis synthesis NN cord-009571-mygj2nd4 1585 13 by by IN cord-009571-mygj2nd4 1585 14 cartilage cartilage NN cord-009571-mygj2nd4 1585 15 . . . cord-009571-mygj2nd4 1586 1 Animals animal NNS cord-009571-mygj2nd4 1586 2 were be VBD cord-009571-mygj2nd4 1586 3 killed kill VBN cord-009571-mygj2nd4 1586 4 12 12 CD cord-009571-mygj2nd4 1586 5 weeks week NNS cord-009571-mygj2nd4 1586 6 post post VBP cord-009571-mygj2nd4 1586 7 partial partial JJ cord-009571-mygj2nd4 1586 8 meniscectomy meniscectomy NN cord-009571-mygj2nd4 1586 9 , , , cord-009571-mygj2nd4 1586 10 and and CC cord-009571-mygj2nd4 1586 11 osteoarthritic osteoarthritic JJ cord-009571-mygj2nd4 1586 12 lesions lesion NNS cord-009571-mygj2nd4 1586 13 were be VBD cord-009571-mygj2nd4 1586 14 noted note VBN cord-009571-mygj2nd4 1586 15 . . . cord-009571-mygj2nd4 1587 1 Knee knee NN cord-009571-mygj2nd4 1587 2 sections section NNS cord-009571-mygj2nd4 1587 3 processed process VBN cord-009571-mygj2nd4 1587 4 for for IN cord-009571-mygj2nd4 1587 5 histologic histologic JJ cord-009571-mygj2nd4 1587 6 examination examination NN cord-009571-mygj2nd4 1587 7 were be VBD cord-009571-mygj2nd4 1587 8 stained stain VBN cord-009571-mygj2nd4 1587 9 with with IN cord-009571-mygj2nd4 1587 10 H h NN cord-009571-mygj2nd4 1587 11 and and CC cord-009571-mygj2nd4 1587 12 E e NN cord-009571-mygj2nd4 1587 13 and and CC cord-009571-mygj2nd4 1587 14 safranin-0 safranin-0 NNP cord-009571-mygj2nd4 1587 15 with with IN cord-009571-mygj2nd4 1587 16 fast fast JJ cord-009571-mygj2nd4 1587 17 green green JJ cord-009571-mygj2nd4 1587 18 counterstain counterstain NN cord-009571-mygj2nd4 1587 19 . . . cord-009571-mygj2nd4 1588 1 Cartilage cartilage NN cord-009571-mygj2nd4 1588 2 metabolism metabolism NN cord-009571-mygj2nd4 1588 3 in in IN cord-009571-mygj2nd4 1588 4 the the DT cord-009571-mygj2nd4 1588 5 3 3 CD cord-009571-mygj2nd4 1588 6 groups group NNS cord-009571-mygj2nd4 1588 7 was be VBD cord-009571-mygj2nd4 1588 8 examined examine VBN cord-009571-mygj2nd4 1588 9 by by IN cord-009571-mygj2nd4 1588 10 in in FW cord-009571-mygj2nd4 1588 11 vitro vitro FW cord-009571-mygj2nd4 1588 12 measurement measurement NN cord-009571-mygj2nd4 1588 13 of of IN cord-009571-mygj2nd4 1588 14 " " '' cord-009571-mygj2nd4 1588 15 " " `` cord-009571-mygj2nd4 1588 16 so so RB cord-009571-mygj2nd4 1588 17 , , , cord-009571-mygj2nd4 1588 18 incorporation incorporation NN cord-009571-mygj2nd4 1588 19 into into IN cord-009571-mygj2nd4 1588 20 articular articular JJ cord-009571-mygj2nd4 1588 21 cartilage cartilage NN cord-009571-mygj2nd4 1588 22 after after IN cord-009571-mygj2nd4 1588 23 2 2 CD cord-009571-mygj2nd4 1588 24 hour hour NN cord-009571-mygj2nd4 1588 25 incubation incubation NN cord-009571-mygj2nd4 1588 26 in in IN cord-009571-mygj2nd4 1588 27 Dulbecco Dulbecco NNP cord-009571-mygj2nd4 1588 28 's 's POS cord-009571-mygj2nd4 1588 29 modified modify VBN cord-009571-mygj2nd4 1588 30 Eagle Eagle NNP cord-009571-mygj2nd4 1588 31 medium medium NN cord-009571-mygj2nd4 1588 32 . . . cord-009571-mygj2nd4 1589 1 Medial medial JJ cord-009571-mygj2nd4 1589 2 and and CC cord-009571-mygj2nd4 1589 3 lateral lateral JJ cord-009571-mygj2nd4 1589 4 components component NNS cord-009571-mygj2nd4 1589 5 of of IN cord-009571-mygj2nd4 1589 6 femoral femoral JJ cord-009571-mygj2nd4 1589 7 and and CC cord-009571-mygj2nd4 1589 8 tibia1 tibia1 VBD cord-009571-mygj2nd4 1589 9 knee knee NN cord-009571-mygj2nd4 1589 10 joint joint JJ cord-009571-mygj2nd4 1589 11 surfaces surface NNS cord-009571-mygj2nd4 1589 12 were be VBD cord-009571-mygj2nd4 1589 13 studied study VBN cord-009571-mygj2nd4 1589 14 separately separately RB cord-009571-mygj2nd4 1589 15 . . . cord-009571-mygj2nd4 1590 1 Normal normal JJ cord-009571-mygj2nd4 1590 2 unoperated unoperated JJ cord-009571-mygj2nd4 1590 3 knees knee NNS cord-009571-mygj2nd4 1590 4 served serve VBD cord-009571-mygj2nd4 1590 5 as as IN cord-009571-mygj2nd4 1590 6 additional additional JJ cord-009571-mygj2nd4 1590 7 controls control NNS cord-009571-mygj2nd4 1590 8 . . . cord-009571-mygj2nd4 1591 1 Frequency frequency NN cord-009571-mygj2nd4 1591 2 and and CC cord-009571-mygj2nd4 1591 3 severity severity NN cord-009571-mygj2nd4 1591 4 of of IN cord-009571-mygj2nd4 1591 5 osteoarthritic osteoarthritic JJ cord-009571-mygj2nd4 1591 6 lesions lesion NNS cord-009571-mygj2nd4 1591 7 were be VBD cord-009571-mygj2nd4 1591 8 the the DT cord-009571-mygj2nd4 1591 9 same same JJ cord-009571-mygj2nd4 1591 10 in in IN cord-009571-mygj2nd4 1591 11 all all DT cord-009571-mygj2nd4 1591 12 3 3 CD cord-009571-mygj2nd4 1591 13 groups group NNS cord-009571-mygj2nd4 1591 14 . . . cord-009571-mygj2nd4 1592 1 Osteoarthritic osteoarthritic JJ cord-009571-mygj2nd4 1592 2 and and CC cord-009571-mygj2nd4 1592 3 normal normal JJ cord-009571-mygj2nd4 1592 4 articular articular JJ cord-009571-mygj2nd4 1592 5 cartilage cartilage NN cord-009571-mygj2nd4 1592 6 from from IN cord-009571-mygj2nd4 1592 7 estradiol estradiol NN cord-009571-mygj2nd4 1592 8 - - HYPH cord-009571-mygj2nd4 1592 9 treated treat VBN cord-009571-mygj2nd4 1592 10 animals animal NNS cord-009571-mygj2nd4 1592 11 revealed reveal VBD cord-009571-mygj2nd4 1592 12 statistically statistically RB cord-009571-mygj2nd4 1592 13 significant significant JJ cord-009571-mygj2nd4 1592 14 reduction reduction NN cord-009571-mygj2nd4 1592 15 in in IN cord-009571-mygj2nd4 1592 16 s6S04 s6s04 NN cord-009571-mygj2nd4 1592 17 incorporation incorporation NN cord-009571-mygj2nd4 1592 18 as as IN cord-009571-mygj2nd4 1592 19 compared compare VBN cord-009571-mygj2nd4 1592 20 to to IN cord-009571-mygj2nd4 1592 21 untreated untreated JJ cord-009571-mygj2nd4 1592 22 animals animal NNS cord-009571-mygj2nd4 1592 23 . . . cord-009571-mygj2nd4 1593 1 Androgens androgen NNS cord-009571-mygj2nd4 1593 2 had have VBD cord-009571-mygj2nd4 1593 3 no no DT cord-009571-mygj2nd4 1593 4 significant significant JJ cord-009571-mygj2nd4 1593 5 effect effect NN cord-009571-mygj2nd4 1593 6 on on IN cord-009571-mygj2nd4 1593 7 36S04 36s04 CD cord-009571-mygj2nd4 1593 8 incorporation incorporation NN cord-009571-mygj2nd4 1593 9 . . . cord-009571-mygj2nd4 1594 1 Femoral Femoral NNP cord-009571-mygj2nd4 1594 2 s6S0 s6S0 NNP cord-009571-mygj2nd4 1594 3 , , , cord-009571-mygj2nd4 1594 4 incorporation incorporation NN cord-009571-mygj2nd4 1594 5 was be VBD cord-009571-mygj2nd4 1594 6 uniformly uniformly RB cord-009571-mygj2nd4 1594 7 greater great JJR cord-009571-mygj2nd4 1594 8 than than IN cord-009571-mygj2nd4 1594 9 tibial tibial NN cord-009571-mygj2nd4 1594 10 90 90 CD cord-009571-mygj2nd4 1594 11 , , , cord-009571-mygj2nd4 1594 12 incorporation incorporation NN cord-009571-mygj2nd4 1594 13 in in IN cord-009571-mygj2nd4 1594 14 all all DT cord-009571-mygj2nd4 1594 15 groups group NNS cord-009571-mygj2nd4 1594 16 ( ( -LRB- cord-009571-mygj2nd4 1594 17 P p NN cord-009571-mygj2nd4 1594 18 < < XX cord-009571-mygj2nd4 1594 19 0.05 0.05 CD cord-009571-mygj2nd4 1594 20 ) ) -RRB- cord-009571-mygj2nd4 1594 21 . . . cord-009571-mygj2nd4 1595 1 Estradiol estradiol NN cord-009571-mygj2nd4 1595 2 did do VBD cord-009571-mygj2nd4 1595 3 not not RB cord-009571-mygj2nd4 1595 4 ameliorate ameliorate VB cord-009571-mygj2nd4 1595 5 nor nor CC cord-009571-mygj2nd4 1595 6 testosterone testosterone NN cord-009571-mygj2nd4 1595 7 worsen worsen VBP cord-009571-mygj2nd4 1595 8 OA OA NNP cord-009571-mygj2nd4 1595 9 . . . cord-009571-mygj2nd4 1596 1 Both both DT cord-009571-mygj2nd4 1596 2 normal normal JJ cord-009571-mygj2nd4 1596 3 and and CC cord-009571-mygj2nd4 1596 4 osteoarthritic osteoarthritic JJ cord-009571-mygj2nd4 1596 5 articular articular JJ cord-009571-mygj2nd4 1596 6 cartilage cartilage NN cord-009571-mygj2nd4 1596 7 were be VBD cord-009571-mygj2nd4 1596 8 susceptible susceptible JJ cord-009571-mygj2nd4 1596 9 to to IN cord-009571-mygj2nd4 1596 10 estradiol estradiol NN cord-009571-mygj2nd4 1596 11 suppression suppression NN cord-009571-mygj2nd4 1596 12 of of IN cord-009571-mygj2nd4 1596 13 proteoglycan proteoglycan JJ cord-009571-mygj2nd4 1596 14 synthesis synthesis NN cord-009571-mygj2nd4 1596 15 . . . cord-009571-mygj2nd4 1597 1 The the DT cord-009571-mygj2nd4 1597 2 poor poor JJ cord-009571-mygj2nd4 1597 3 correlation correlation NN cord-009571-mygj2nd4 1597 4 between between IN cord-009571-mygj2nd4 1597 5 severity severity NN cord-009571-mygj2nd4 1597 6 of of IN cord-009571-mygj2nd4 1597 7 OA OA NNP cord-009571-mygj2nd4 1597 8 and and CC cord-009571-mygj2nd4 1597 9 rate rate NN cord-009571-mygj2nd4 1597 10 of of IN cord-009571-mygj2nd4 1597 11 PG PG NNP cord-009571-mygj2nd4 1597 12 synthesis synthesis NN cord-009571-mygj2nd4 1597 13 may may MD cord-009571-mygj2nd4 1597 14 require require VB cord-009571-mygj2nd4 1597 15 reevaluation reevaluation NN cord-009571-mygj2nd4 1597 16 of of IN cord-009571-mygj2nd4 1597 17 the the DT cord-009571-mygj2nd4 1597 18 role role NN cord-009571-mygj2nd4 1597 19 of of IN cord-009571-mygj2nd4 1597 20 the the DT cord-009571-mygj2nd4 1597 21 latter latter JJ cord-009571-mygj2nd4 1597 22 in in IN cord-009571-mygj2nd4 1597 23 the the DT cord-009571-mygj2nd4 1597 24 OA OA NNP cord-009571-mygj2nd4 1597 25 disease disease NN cord-009571-mygj2nd4 1597 26 process process NN cord-009571-mygj2nd4 1597 27 . . . cord-009571-mygj2nd4 1598 1 Variations variation NNS cord-009571-mygj2nd4 1598 2 in in IN cord-009571-mygj2nd4 1598 3 cartilage cartilage NN cord-009571-mygj2nd4 1598 4 metabolism metabolism NN cord-009571-mygj2nd4 1598 5 from from IN cord-009571-mygj2nd4 1598 6 different different JJ cord-009571-mygj2nd4 1598 7 surfaces surface NNS cord-009571-mygj2nd4 1598 8 ( ( -LRB- cord-009571-mygj2nd4 1598 9 femoral femoral JJ cord-009571-mygj2nd4 1598 10 versus versus IN cord-009571-mygj2nd4 1598 11 tibial tibial NN cord-009571-mygj2nd4 1598 12 ) ) -RRB- cord-009571-mygj2nd4 1598 13 may may MD cord-009571-mygj2nd4 1598 14 relate relate VB cord-009571-mygj2nd4 1598 15 to to IN cord-009571-mygj2nd4 1598 16 known know VBN cord-009571-mygj2nd4 1598 17 differences difference NNS cord-009571-mygj2nd4 1598 18 in in IN cord-009571-mygj2nd4 1598 19 susceptibility susceptibility NN cord-009571-mygj2nd4 1598 20 of of IN cord-009571-mygj2nd4 1598 21 joints joint NNS cord-009571-mygj2nd4 1598 22 to to IN cord-009571-mygj2nd4 1598 23 development development NN cord-009571-mygj2nd4 1598 24 of of IN cord-009571-mygj2nd4 1598 25 OA OA NNP cord-009571-mygj2nd4 1598 26 . . . cord-009571-mygj2nd4 1599 1 We -PRON- PRP cord-009571-mygj2nd4 1599 2 have have VBP cord-009571-mygj2nd4 1599 3 been be VBN cord-009571-mygj2nd4 1599 4 analyzing analyze VBG cord-009571-mygj2nd4 1599 5 antibody antibody NN cord-009571-mygj2nd4 1599 6 activities activity NNS cord-009571-mygj2nd4 1599 7 in in IN cord-009571-mygj2nd4 1599 8 sera sera NNP cord-009571-mygj2nd4 1599 9 from from IN cord-009571-mygj2nd4 1599 10 individuals individual NNS cord-009571-mygj2nd4 1599 11 working work VBG cord-009571-mygj2nd4 1599 12 in in IN cord-009571-mygj2nd4 1599 13 various various JJ cord-009571-mygj2nd4 1599 14 laboratories laboratory NNS cord-009571-mygj2nd4 1599 15 and and CC cord-009571-mygj2nd4 1599 16 in in IN cord-009571-mygj2nd4 1599 17 sera sera NNP cord-009571-mygj2nd4 1599 18 from from IN cord-009571-mygj2nd4 1599 19 a a DT cord-009571-mygj2nd4 1599 20 normal normal JJ cord-009571-mygj2nd4 1599 21 population population NN cord-009571-mygj2nd4 1599 22 . . . cord-009571-mygj2nd4 1600 1 Compared compare VBN cord-009571-mygj2nd4 1600 2 to to IN cord-009571-mygj2nd4 1600 3 the the DT cord-009571-mygj2nd4 1600 4 normal normal JJ cord-009571-mygj2nd4 1600 5 sample sample NN cord-009571-mygj2nd4 1600 6 , , , cord-009571-mygj2nd4 1600 7 the the DT cord-009571-mygj2nd4 1600 8 prevalence prevalence NN cord-009571-mygj2nd4 1600 9 of of IN cord-009571-mygj2nd4 1600 10 elevated elevated JJ cord-009571-mygj2nd4 1600 11 anti anti JJ cord-009571-mygj2nd4 1600 12 - - JJ cord-009571-mygj2nd4 1600 13 DNA dna JJ cord-009571-mygj2nd4 1600 14 activity activity NN cord-009571-mygj2nd4 1600 15 was be VBD cord-009571-mygj2nd4 1600 16 significantly significantly RB cord-009571-mygj2nd4 1600 17 greater great JJR cord-009571-mygj2nd4 1600 18 in in IN cord-009571-mygj2nd4 1600 19 samples sample NNS cord-009571-mygj2nd4 1600 20 of of IN cord-009571-mygj2nd4 1600 21 sera sera NNP cord-009571-mygj2nd4 1600 22 from from IN cord-009571-mygj2nd4 1600 23 over over IN cord-009571-mygj2nd4 1600 24 40 40 CD cord-009571-mygj2nd4 1600 25 personnel personnel NNS cord-009571-mygj2nd4 1600 26 in in IN cord-009571-mygj2nd4 1600 27 systemic systemic JJ cord-009571-mygj2nd4 1600 28 lupus lupus NN cord-009571-mygj2nd4 1600 29 erythematosus erythematosus NN cord-009571-mygj2nd4 1600 30 ( ( -LRB- cord-009571-mygj2nd4 1600 31 SLE SLE NNP cord-009571-mygj2nd4 1600 32 ) ) -RRB- cord-009571-mygj2nd4 1600 33 laboratories laboratory NNS cord-009571-mygj2nd4 1600 34 ( ( -LRB- cord-009571-mygj2nd4 1600 35 P p NN cord-009571-mygj2nd4 1600 36 < < XX cord-009571-mygj2nd4 1600 37 0.001 0.001 CD cord-009571-mygj2nd4 1600 38 ) ) -RRB- cord-009571-mygj2nd4 1600 39 , , , cord-009571-mygj2nd4 1600 40 from from IN cord-009571-mygj2nd4 1600 41 laboratories laboratory NNS cord-009571-mygj2nd4 1600 42 involved involve VBN cord-009571-mygj2nd4 1600 43 with with IN cord-009571-mygj2nd4 1600 44 nucleic nucleic JJ cord-009571-mygj2nd4 1600 45 acids acid NNS cord-009571-mygj2nd4 1600 46 ( ( -LRB- cord-009571-mygj2nd4 1600 47 P p NN cord-009571-mygj2nd4 1600 48 < < XX cord-009571-mygj2nd4 1600 49 0.001 0.001 CD cord-009571-mygj2nd4 1600 50 ) ) -RRB- cord-009571-mygj2nd4 1600 51 , , , cord-009571-mygj2nd4 1600 52 and and CC cord-009571-mygj2nd4 1600 53 from from IN cord-009571-mygj2nd4 1600 54 routine routine JJ cord-009571-mygj2nd4 1600 55 hospital hospital NN cord-009571-mygj2nd4 1600 56 laboratory laboratory NN cord-009571-mygj2nd4 1600 57 personnel personnel NNS cord-009571-mygj2nd4 1600 58 ( ( -LRB- cord-009571-mygj2nd4 1600 59 P p NN cord-009571-mygj2nd4 1600 60 < < XX cord-009571-mygj2nd4 1600 61 0.01 0.01 CD cord-009571-mygj2nd4 1600 62 ) ) -RRB- cord-009571-mygj2nd4 1600 63 . . . cord-009571-mygj2nd4 1601 1 Evidence evidence NN cord-009571-mygj2nd4 1601 2 that that IN cord-009571-mygj2nd4 1601 3 this this DT cord-009571-mygj2nd4 1601 4 anti anti JJ cord-009571-mygj2nd4 1601 5 - - JJ cord-009571-mygj2nd4 1601 6 DNA dna JJ cord-009571-mygj2nd4 1601 7 activity activity NN cord-009571-mygj2nd4 1601 8 was be VBD cord-009571-mygj2nd4 1601 9 due due JJ cord-009571-mygj2nd4 1601 10 to to IN cord-009571-mygj2nd4 1601 11 gammaglobulin gammaglobulin NNP cord-009571-mygj2nd4 1601 12 was be VBD cord-009571-mygj2nd4 1601 13 obtained obtain VBN cord-009571-mygj2nd4 1601 14 by by IN cord-009571-mygj2nd4 1601 15 the the DT cord-009571-mygj2nd4 1601 16 presence presence NN cord-009571-mygj2nd4 1601 17 of of IN cord-009571-mygj2nd4 1602 1 Y Y NNP cord-009571-mygj2nd4 1602 2 -D -D NNP cord-009571-mygj2nd4 1602 3 N N NNP cord-009571-mygj2nd4 1602 4 A A NNP cord-009571-mygj2nd4 1602 5 bound bind VBN cord-009571-mygj2nd4 1602 6 to to IN cord-009571-mygj2nd4 1602 7 IgG IgG NNP cord-009571-mygj2nd4 1602 8 in in IN cord-009571-mygj2nd4 1602 9 a a DT cord-009571-mygj2nd4 1602 10 radioautograph radioautograph NN cord-009571-mygj2nd4 1602 11 . . . cord-009571-mygj2nd4 1603 1 In in IN cord-009571-mygj2nd4 1603 2 addition addition NN cord-009571-mygj2nd4 1603 3 , , , cord-009571-mygj2nd4 1603 4 differences difference NNS cord-009571-mygj2nd4 1603 5 were be VBD cord-009571-mygj2nd4 1603 6 found find VBN cord-009571-mygj2nd4 1603 7 in in IN cord-009571-mygj2nd4 1603 8 the the DT cord-009571-mygj2nd4 1603 9 prevalence prevalence NN cord-009571-mygj2nd4 1603 10 of of IN cord-009571-mygj2nd4 1603 11 DNA dna NN cord-009571-mygj2nd4 1603 12 reactivity reactivity NN cord-009571-mygj2nd4 1603 13 between between IN cord-009571-mygj2nd4 1603 14 the the DT cord-009571-mygj2nd4 1603 15 normal normal JJ cord-009571-mygj2nd4 1603 16 sample sample NN cord-009571-mygj2nd4 1603 17 and and CC cord-009571-mygj2nd4 1603 18 the the DT cord-009571-mygj2nd4 1603 19 samples sample NNS cord-009571-mygj2nd4 1603 20 from from IN cord-009571-mygj2nd4 1603 21 the the DT cord-009571-mygj2nd4 1603 22 three three CD cord-009571-mygj2nd4 1603 23 laboratory laboratory NN cord-009571-mygj2nd4 1603 24 groups group NNS cord-009571-mygj2nd4 1603 25 when when WRB cord-009571-mygj2nd4 1603 26 anti anti JJ cord-009571-mygj2nd4 1603 27 - - JJ cord-009571-mygj2nd4 1603 28 human human JJ cord-009571-mygj2nd4 1603 29 gammaglobulin gammaglobulin NN cord-009571-mygj2nd4 1603 30 was be VBD cord-009571-mygj2nd4 1603 31 used use VBN cord-009571-mygj2nd4 1603 32 as as IN cord-009571-mygj2nd4 1603 33 the the DT cord-009571-mygj2nd4 1603 34 precipitating precipitate VBG cord-009571-mygj2nd4 1603 35 agent agent NN cord-009571-mygj2nd4 1603 36 . . . cord-009571-mygj2nd4 1604 1 Also also RB cord-009571-mygj2nd4 1604 2 , , , cord-009571-mygj2nd4 1604 3 we -PRON- PRP cord-009571-mygj2nd4 1604 4 have have VBP cord-009571-mygj2nd4 1604 5 isolated isolate VBN cord-009571-mygj2nd4 1604 6 the the DT cord-009571-mygj2nd4 1604 7 material material NN cord-009571-mygj2nd4 1604 8 from from IN cord-009571-mygj2nd4 1604 9 a a DT cord-009571-mygj2nd4 1604 10 serum serum NN cord-009571-mygj2nd4 1604 11 containing contain VBG cord-009571-mygj2nd4 1604 12 high high JJ cord-009571-mygj2nd4 1604 13 DNA dna NN cord-009571-mygj2nd4 1604 14 reactivity reactivity NN cord-009571-mygj2nd4 1604 15 by by IN cord-009571-mygj2nd4 1604 16 a a DT cord-009571-mygj2nd4 1604 17 DNA dna NN cord-009571-mygj2nd4 1604 18 - - HYPH cord-009571-mygj2nd4 1604 19 cellulose cellulose NN cord-009571-mygj2nd4 1604 20 affinity affinity NN cord-009571-mygj2nd4 1604 21 technique technique NN cord-009571-mygj2nd4 1604 22 , , , cord-009571-mygj2nd4 1604 23 and and CC cord-009571-mygj2nd4 1604 24 the the DT cord-009571-mygj2nd4 1604 25 fraction fraction NN cord-009571-mygj2nd4 1604 26 with with IN cord-009571-mygj2nd4 1604 27 DNA dna NN cord-009571-mygj2nd4 1604 28 binding binding NN cord-009571-mygj2nd4 1604 29 activity activity NN cord-009571-mygj2nd4 1604 30 contained contain VBN cord-009571-mygj2nd4 1604 31 only only RB cord-009571-mygj2nd4 1604 32 IgG. IgG. NNP cord-009571-mygj2nd4 1604 33 Lymphocytotoxic Lymphocytotoxic NNP cord-009571-mygj2nd4 1604 34 activity activity NN cord-009571-mygj2nd4 1604 35 was be VBD cord-009571-mygj2nd4 1604 36 also also RB cord-009571-mygj2nd4 1604 37 increased increase VBN cord-009571-mygj2nd4 1604 38 in in IN cord-009571-mygj2nd4 1604 39 the the DT cord-009571-mygj2nd4 1604 40 sera sera NNP cord-009571-mygj2nd4 1604 41 from from IN cord-009571-mygj2nd4 1604 42 SLE SLE NNP cord-009571-mygj2nd4 1604 43 laboratory laboratory NN cord-009571-mygj2nd4 1604 44 personnel personnel NNS cord-009571-mygj2nd4 1604 45 compared compare VBN cord-009571-mygj2nd4 1604 46 to to IN cord-009571-mygj2nd4 1604 47 the the DT cord-009571-mygj2nd4 1604 48 other other JJ cord-009571-mygj2nd4 1604 49 laboratories laboratory NNS cord-009571-mygj2nd4 1604 50 and and CC cord-009571-mygj2nd4 1604 51 to to IN cord-009571-mygj2nd4 1604 52 the the DT cord-009571-mygj2nd4 1604 53 normal normal JJ cord-009571-mygj2nd4 1604 54 sample sample NN cord-009571-mygj2nd4 1604 55 ( ( -LRB- cord-009571-mygj2nd4 1604 56 P p NN cord-009571-mygj2nd4 1604 57 < < XX cord-009571-mygj2nd4 1604 58 0.0005 0.0005 CD cord-009571-mygj2nd4 1604 59 ) ) -RRB- cord-009571-mygj2nd4 1604 60 , , , cord-009571-mygj2nd4 1604 61 as as IN cord-009571-mygj2nd4 1604 62 previously previously RB cord-009571-mygj2nd4 1604 63 reported report VBN cord-009571-mygj2nd4 1604 64 ( ( -LRB- cord-009571-mygj2nd4 1604 65 XIV XIV NNP cord-009571-mygj2nd4 1604 66 International International NNP cord-009571-mygj2nd4 1604 67 Congress Congress NNP cord-009571-mygj2nd4 1604 68 of of IN cord-009571-mygj2nd4 1604 69 Rheumatology Rheumatology NNP cord-009571-mygj2nd4 1604 70 , , , cord-009571-mygj2nd4 1604 71 Abstract Abstract NNP cord-009571-mygj2nd4 1604 72 p. p. NN cord-009571-mygj2nd4 1604 73 131 131 CD cord-009571-mygj2nd4 1604 74 , , , cord-009571-mygj2nd4 1604 75 1977 1977 CD cord-009571-mygj2nd4 1604 76 ) ) -RRB- cord-009571-mygj2nd4 1604 77 . . . cord-009571-mygj2nd4 1605 1 Immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 1605 2 levels level NNS cord-009571-mygj2nd4 1605 3 were be VBD cord-009571-mygj2nd4 1605 4 analyzed analyze VBN cord-009571-mygj2nd4 1605 5 by by IN cord-009571-mygj2nd4 1605 6 immunofluorescence immunofluorescence NN cord-009571-mygj2nd4 1605 7 . . . cord-009571-mygj2nd4 1606 1 There there EX cord-009571-mygj2nd4 1606 2 was be VBD cord-009571-mygj2nd4 1606 3 no no DT cord-009571-mygj2nd4 1606 4 significant significant JJ cord-009571-mygj2nd4 1606 5 difference difference NN cord-009571-mygj2nd4 1606 6 in in IN cord-009571-mygj2nd4 1606 7 the the DT cord-009571-mygj2nd4 1606 8 IgG IgG NNP cord-009571-mygj2nd4 1606 9 and and CC cord-009571-mygj2nd4 1606 10 IgM IgM NNP cord-009571-mygj2nd4 1606 11 levels level NNS cord-009571-mygj2nd4 1606 12 , , , cord-009571-mygj2nd4 1606 13 but but CC cord-009571-mygj2nd4 1606 14 the the DT cord-009571-mygj2nd4 1606 15 mean mean JJ cord-009571-mygj2nd4 1606 16 IgA IgA NNP cord-009571-mygj2nd4 1606 17 level level NN cord-009571-mygj2nd4 1606 18 of of IN cord-009571-mygj2nd4 1606 19 the the DT cord-009571-mygj2nd4 1606 20 SLE SLE NNP cord-009571-mygj2nd4 1606 21 laboratory laboratory NN cord-009571-mygj2nd4 1606 22 personnel personnel NNS cord-009571-mygj2nd4 1606 23 was be VBD cord-009571-mygj2nd4 1606 24 2.27 2.27 CD cord-009571-mygj2nd4 1606 25 f f NNP cord-009571-mygj2nd4 1606 26 0.96 0.96 CD cord-009571-mygj2nd4 1606 27 mg mg NNP cord-009571-mygj2nd4 1606 28 / / SYM cord-009571-mygj2nd4 1606 29 ml ml NNP cord-009571-mygj2nd4 1607 1 compared compare VBN cord-009571-mygj2nd4 1607 2 to to IN cord-009571-mygj2nd4 1607 3 1.42 1.42 CD cord-009571-mygj2nd4 1607 4 * * NFP cord-009571-mygj2nd4 1607 5 0.76 0.76 CD cord-009571-mygj2nd4 1607 6 mg mg NNP cord-009571-mygj2nd4 1607 7 / / SYM cord-009571-mygj2nd4 1607 8 ml ml XX cord-009571-mygj2nd4 1607 9 in in IN cord-009571-mygj2nd4 1607 10 the the DT cord-009571-mygj2nd4 1607 11 normal normal JJ cord-009571-mygj2nd4 1607 12 sample sample NN cord-009571-mygj2nd4 1608 1 ( ( -LRB- cord-009571-mygj2nd4 1608 2 P p NN cord-009571-mygj2nd4 1608 3 < < XX cord-009571-mygj2nd4 1608 4 0.001 0.001 CD cord-009571-mygj2nd4 1608 5 ) ) -RRB- cord-009571-mygj2nd4 1608 6 . . . cord-009571-mygj2nd4 1609 1 When when WRB cord-009571-mygj2nd4 1609 2 sera sera NNP cord-009571-mygj2nd4 1609 3 from from IN cord-009571-mygj2nd4 1609 4 17 17 CD cord-009571-mygj2nd4 1609 5 of of IN cord-009571-mygj2nd4 1609 6 the the DT cord-009571-mygj2nd4 1609 7 laboratory laboratory NN cord-009571-mygj2nd4 1609 8 personnel personnel NNS cord-009571-mygj2nd4 1609 9 with with IN cord-009571-mygj2nd4 1609 10 the the DT cord-009571-mygj2nd4 1609 11 highest high JJS cord-009571-mygj2nd4 1609 12 anti anti JJ cord-009571-mygj2nd4 1609 13 - - JJ cord-009571-mygj2nd4 1609 14 DNA dna JJ cord-009571-mygj2nd4 1609 15 activities activity NNS cord-009571-mygj2nd4 1609 16 were be VBD cord-009571-mygj2nd4 1609 17 compared compare VBN cord-009571-mygj2nd4 1609 18 to to IN cord-009571-mygj2nd4 1609 19 17 17 CD cord-009571-mygj2nd4 1609 20 normal normal JJ cord-009571-mygj2nd4 1609 21 sera sera NNP cord-009571-mygj2nd4 1609 22 , , , cord-009571-mygj2nd4 1609 23 additional additional JJ cord-009571-mygj2nd4 1609 24 abnormalities abnormality NNS cord-009571-mygj2nd4 1609 25 were be VBD cord-009571-mygj2nd4 1609 26 found find VBN cord-009571-mygj2nd4 1609 27 . . . cord-009571-mygj2nd4 1610 1 Not not RB cord-009571-mygj2nd4 1610 2 only only RB cord-009571-mygj2nd4 1610 3 was be VBD cord-009571-mygj2nd4 1610 4 there there EX cord-009571-mygj2nd4 1610 5 a a DT cord-009571-mygj2nd4 1610 6 significant significant JJ cord-009571-mygj2nd4 1610 7 difference difference NN cord-009571-mygj2nd4 1610 8 in in IN cord-009571-mygj2nd4 1610 9 the the DT cord-009571-mygj2nd4 1610 10 anti anti JJ cord-009571-mygj2nd4 1610 11 - - JJ cord-009571-mygj2nd4 1610 12 DNA dna JJ cord-009571-mygj2nd4 1610 13 activity activity NN cord-009571-mygj2nd4 1610 14 ( ( -LRB- cord-009571-mygj2nd4 1610 15 P p NN cord-009571-mygj2nd4 1610 16 < < XX cord-009571-mygj2nd4 1610 17 0.001 0.001 CD cord-009571-mygj2nd4 1610 18 ) ) -RRB- cord-009571-mygj2nd4 1610 19 and and CC cord-009571-mygj2nd4 1610 20 the the DT cord-009571-mygj2nd4 1610 21 IgA IgA NNP cord-009571-mygj2nd4 1610 22 levels level NNS cord-009571-mygj2nd4 1610 23 ( ( -LRB- cord-009571-mygj2nd4 1610 24 P p NN cord-009571-mygj2nd4 1610 25 < < XX cord-009571-mygj2nd4 1610 26 0.001 0.001 CD cord-009571-mygj2nd4 1610 27 ) ) -RRB- cord-009571-mygj2nd4 1610 28 , , , cord-009571-mygj2nd4 1610 29 but but CC cord-009571-mygj2nd4 1610 30 also also RB cord-009571-mygj2nd4 1610 31 the the DT cord-009571-mygj2nd4 1610 32 mean mean JJ cord-009571-mygj2nd4 1610 33 IgM IgM NNP cord-009571-mygj2nd4 1610 34 level level NN cord-009571-mygj2nd4 1610 35 in in IN cord-009571-mygj2nd4 1610 36 the the DT cord-009571-mygj2nd4 1610 37 laboratory laboratory NN cord-009571-mygj2nd4 1610 38 personnel personnel NNS cord-009571-mygj2nd4 1610 39 ( ( -LRB- cord-009571-mygj2nd4 1610 40 1.93 1.93 CD cord-009571-mygj2nd4 1610 41 f f NNP cord-009571-mygj2nd4 1610 42 0.58 0.58 CD cord-009571-mygj2nd4 1610 43 mg mg NNP cord-009571-mygj2nd4 1610 44 / / SYM cord-009571-mygj2nd4 1610 45 ml ml NNP cord-009571-mygj2nd4 1610 46 ) ) -RRB- cord-009571-mygj2nd4 1610 47 was be VBD cord-009571-mygj2nd4 1610 48 significantly significantly RB cord-009571-mygj2nd4 1610 49 greater great JJR cord-009571-mygj2nd4 1610 50 than than IN cord-009571-mygj2nd4 1610 51 in in IN cord-009571-mygj2nd4 1610 52 the the DT cord-009571-mygj2nd4 1610 53 normal normal JJ cord-009571-mygj2nd4 1610 54 sera sera NNP cord-009571-mygj2nd4 1610 55 ( ( -LRB- cord-009571-mygj2nd4 1610 56 1.01 1.01 CD cord-009571-mygj2nd4 1610 57 f f NNP cord-009571-mygj2nd4 1610 58 0.75 0.75 CD cord-009571-mygj2nd4 1610 59 mg mg NNP cord-009571-mygj2nd4 1610 60 / / SYM cord-009571-mygj2nd4 1610 61 ml)(P ml)(p NN cord-009571-mygj2nd4 1610 62 < < XX cord-009571-mygj2nd4 1610 63 0.001 0.001 CD cord-009571-mygj2nd4 1610 64 ) ) -RRB- cord-009571-mygj2nd4 1610 65 . . . cord-009571-mygj2nd4 1611 1 No no DT cord-009571-mygj2nd4 1611 2 difference difference NN cord-009571-mygj2nd4 1611 3 in in IN cord-009571-mygj2nd4 1611 4 the the DT cord-009571-mygj2nd4 1611 5 mean mean JJ cord-009571-mygj2nd4 1611 6 IgG IgG NNP cord-009571-mygj2nd4 1611 7 levels level NNS cord-009571-mygj2nd4 1611 8 was be VBD cord-009571-mygj2nd4 1611 9 found find VBN cord-009571-mygj2nd4 1611 10 . . . cord-009571-mygj2nd4 1612 1 Of of IN cord-009571-mygj2nd4 1612 2 5 5 CD cord-009571-mygj2nd4 1612 3 additional additional JJ cord-009571-mygj2nd4 1612 4 specific specific JJ cord-009571-mygj2nd4 1612 5 antibody antibody NN cord-009571-mygj2nd4 1612 6 activities activity NNS cord-009571-mygj2nd4 1612 7 quantitated quantitate VBN cord-009571-mygj2nd4 1612 8 by by IN cord-009571-mygj2nd4 1612 9 radioimmunoassay radioimmunoassay NN cord-009571-mygj2nd4 1612 10 , , , cord-009571-mygj2nd4 1612 11 one one CD cord-009571-mygj2nd4 1612 12 of of IN cord-009571-mygj2nd4 1612 13 these these DT cord-009571-mygj2nd4 1612 14 ( ( -LRB- cord-009571-mygj2nd4 1612 15 anti anti JJ cord-009571-mygj2nd4 1612 16 - - JJ cord-009571-mygj2nd4 1612 17 bovine bovine JJ cord-009571-mygj2nd4 1612 18 gammaglobulin gammaglobulin NN cord-009571-mygj2nd4 1612 19 ) ) -RRB- cord-009571-mygj2nd4 1612 20 was be VBD cord-009571-mygj2nd4 1612 21 elevated elevate VBN cord-009571-mygj2nd4 1612 22 more more RBR cord-009571-mygj2nd4 1612 23 frequently frequently RB cord-009571-mygj2nd4 1612 24 in in IN cord-009571-mygj2nd4 1612 25 the the DT cord-009571-mygj2nd4 1612 26 laboratory laboratory NN cord-009571-mygj2nd4 1612 27 personnel personnel NNS cord-009571-mygj2nd4 1612 28 than than IN cord-009571-mygj2nd4 1612 29 in in IN cord-009571-mygj2nd4 1612 30 the the DT cord-009571-mygj2nd4 1612 31 normals normal NNS cord-009571-mygj2nd4 1612 32 ( ( -LRB- cord-009571-mygj2nd4 1612 33 P p NN cord-009571-mygj2nd4 1612 34 < < XX cord-009571-mygj2nd4 1612 35 0.02 0.02 CD cord-009571-mygj2nd4 1612 36 ) ) -RRB- cord-009571-mygj2nd4 1612 37 . . . cord-009571-mygj2nd4 1613 1 The the DT cord-009571-mygj2nd4 1613 2 data datum NNS cord-009571-mygj2nd4 1613 3 suggest suggest VBP cord-009571-mygj2nd4 1613 4 that that IN cord-009571-mygj2nd4 1613 5 laboratory laboratory NN cord-009571-mygj2nd4 1613 6 personnel personnel NNS cord-009571-mygj2nd4 1613 7 tend tend VBP cord-009571-mygj2nd4 1613 8 to to TO cord-009571-mygj2nd4 1613 9 have have VB cord-009571-mygj2nd4 1613 10 an an DT cord-009571-mygj2nd4 1613 11 increased increase VBN cord-009571-mygj2nd4 1613 12 immune immune JJ cord-009571-mygj2nd4 1613 13 reactivity reactivity NN cord-009571-mygj2nd4 1613 14 , , , cord-009571-mygj2nd4 1613 15 particularly particularly RB cord-009571-mygj2nd4 1613 16 those those DT cord-009571-mygj2nd4 1613 17 working work VBG cord-009571-mygj2nd4 1613 18 with with IN cord-009571-mygj2nd4 1613 19 SLE SLE NNP cord-009571-mygj2nd4 1613 20 sera sera NNP cord-009571-mygj2nd4 1613 21 . . . cord-009571-mygj2nd4 1614 1 This this DT cord-009571-mygj2nd4 1614 2 condition condition NN cord-009571-mygj2nd4 1614 3 might may MD cord-009571-mygj2nd4 1614 4 be be VB cord-009571-mygj2nd4 1614 5 due due JJ cord-009571-mygj2nd4 1614 6 to to IN cord-009571-mygj2nd4 1614 7 laboratory laboratory NN cord-009571-mygj2nd4 1614 8 exposure exposure NN cord-009571-mygj2nd4 1614 9 to to IN cord-009571-mygj2nd4 1614 10 a a DT cord-009571-mygj2nd4 1614 11 stimulus stimulus NN cord-009571-mygj2nd4 1614 12 , , , cord-009571-mygj2nd4 1614 13 causing cause VBG cord-009571-mygj2nd4 1614 14 an an DT cord-009571-mygj2nd4 1614 15 immune immune JJ cord-009571-mygj2nd4 1614 16 response response NN cord-009571-mygj2nd4 1614 17 that that WDT cord-009571-mygj2nd4 1614 18 includes include VBZ cord-009571-mygj2nd4 1614 19 autoantibody autoantibody NNP cord-009571-mygj2nd4 1614 20 production production NN cord-009571-mygj2nd4 1614 21 . . . cord-009571-mygj2nd4 1615 1 In in IN cord-009571-mygj2nd4 1615 2 most most JJS cord-009571-mygj2nd4 1615 3 cases case NNS cord-009571-mygj2nd4 1615 4 , , , cord-009571-mygj2nd4 1615 5 amyloid amyloid NNP cord-009571-mygj2nd4 1615 6 arthropathy arthropathy NNP cord-009571-mygj2nd4 1615 7 ( ( -LRB- cord-009571-mygj2nd4 1615 8 AA AA NNP cord-009571-mygj2nd4 1615 9 ) ) -RRB- cord-009571-mygj2nd4 1615 10 has have VBZ cord-009571-mygj2nd4 1615 11 been be VBN cord-009571-mygj2nd4 1615 12 associated associate VBN cord-009571-mygj2nd4 1615 13 with with IN cord-009571-mygj2nd4 1615 14 multiple multiple JJ cord-009571-mygj2nd4 1615 15 myeloma myeloma NN cord-009571-mygj2nd4 1615 16 or or CC cord-009571-mygj2nd4 1615 17 demonstrable demonstrable JJ cord-009571-mygj2nd4 1615 18 paraproteinemia paraproteinemia NN cord-009571-mygj2nd4 1615 19 . . . cord-009571-mygj2nd4 1616 1 Various various JJ cord-009571-mygj2nd4 1616 2 modes mode NNS cord-009571-mygj2nd4 1616 3 of of IN cord-009571-mygj2nd4 1616 4 presentation presentation NN cord-009571-mygj2nd4 1616 5 and and CC cord-009571-mygj2nd4 1616 6 laboratory laboratory NN cord-009571-mygj2nd4 1616 7 features feature NNS cord-009571-mygj2nd4 1616 8 have have VBP cord-009571-mygj2nd4 1616 9 been be VBN cord-009571-mygj2nd4 1616 10 described describe VBN cord-009571-mygj2nd4 1616 11 . . . cord-009571-mygj2nd4 1617 1 We -PRON- PRP cord-009571-mygj2nd4 1617 2 have have VBP cord-009571-mygj2nd4 1617 3 analyzed analyze VBN cord-009571-mygj2nd4 1617 4 clinical clinical JJ cord-009571-mygj2nd4 1617 5 , , , cord-009571-mygj2nd4 1617 6 laboratory laboratory NN cord-009571-mygj2nd4 1617 7 , , , cord-009571-mygj2nd4 1617 8 and and CC cord-009571-mygj2nd4 1617 9 radiographic radiographic JJ cord-009571-mygj2nd4 1617 10 features feature NNS cord-009571-mygj2nd4 1617 11 of of IN cord-009571-mygj2nd4 1617 12 5 5 CD cord-009571-mygj2nd4 1617 13 patients patient NNS cord-009571-mygj2nd4 1617 14 with with IN cord-009571-mygj2nd4 1617 15 AA AA NNP cord-009571-mygj2nd4 1617 16 seen see VBN cord-009571-mygj2nd4 1617 17 over over IN cord-009571-mygj2nd4 1617 18 a a DT cord-009571-mygj2nd4 1617 19 2-year 2-year CD cord-009571-mygj2nd4 1617 20 period period NN cord-009571-mygj2nd4 1617 21 . . . cord-009571-mygj2nd4 1618 1 None none NN cord-009571-mygj2nd4 1618 2 of of IN cord-009571-mygj2nd4 1618 3 these these DT cord-009571-mygj2nd4 1618 4 patients patient NNS cord-009571-mygj2nd4 1618 5 had have VBD cord-009571-mygj2nd4 1618 6 identifiable identifiable JJ cord-009571-mygj2nd4 1618 7 diseases disease NNS cord-009571-mygj2nd4 1618 8 known know VBN cord-009571-mygj2nd4 1618 9 to to TO cord-009571-mygj2nd4 1618 10 cause cause VB cord-009571-mygj2nd4 1618 11 secondary secondary JJ cord-009571-mygj2nd4 1618 12 amyloidosis amyloidosis NN cord-009571-mygj2nd4 1618 13 . . . cord-009571-mygj2nd4 1619 1 Presenting present VBG cord-009571-mygj2nd4 1619 2 symptoms symptom NNS cord-009571-mygj2nd4 1619 3 were be VBD cord-009571-mygj2nd4 1619 4 those those DT cord-009571-mygj2nd4 1619 5 of of IN cord-009571-mygj2nd4 1619 6 carpal carpal NN cord-009571-mygj2nd4 1619 7 tunnel tunnel NN cord-009571-mygj2nd4 1619 8 syndrome syndrome NN cord-009571-mygj2nd4 1619 9 ( ( -LRB- cord-009571-mygj2nd4 1619 10 3 3 CD cord-009571-mygj2nd4 1619 11 : : SYM cord-009571-mygj2nd4 1619 12 5 5 LS cord-009571-mygj2nd4 1619 13 ) ) -RRB- cord-009571-mygj2nd4 1619 14 and/or and/or CC cord-009571-mygj2nd4 1619 15 swollen swollen JJ cord-009571-mygj2nd4 1619 16 hands hand NNS cord-009571-mygj2nd4 1619 17 with with IN cord-009571-mygj2nd4 1619 18 stiffness stiffness NN cord-009571-mygj2nd4 1619 19 ( ( -LRB- cord-009571-mygj2nd4 1619 20 4 4 CD cord-009571-mygj2nd4 1619 21 : : SYM cord-009571-mygj2nd4 1619 22 5 5 CD cord-009571-mygj2nd4 1619 23 ) ) -RRB- cord-009571-mygj2nd4 1619 24 . . . cord-009571-mygj2nd4 1620 1 Periarticular periarticular JJ cord-009571-mygj2nd4 1620 2 tenderness tenderness NN cord-009571-mygj2nd4 1620 3 of of IN cord-009571-mygj2nd4 1620 4 the the DT cord-009571-mygj2nd4 1620 5 hands hand NNS cord-009571-mygj2nd4 1620 6 and and CC cord-009571-mygj2nd4 1620 7 thickened thickened JJ cord-009571-mygj2nd4 1620 8 palmar palmar NN cord-009571-mygj2nd4 1620 9 tendons tendon NNS cord-009571-mygj2nd4 1620 10 were be VBD cord-009571-mygj2nd4 1620 11 noted note VBN cord-009571-mygj2nd4 1620 12 . . . cord-009571-mygj2nd4 1621 1 Pitting pit VBG cord-009571-mygj2nd4 1621 2 edema edema NN cord-009571-mygj2nd4 1621 3 of of IN cord-009571-mygj2nd4 1621 4 the the DT cord-009571-mygj2nd4 1621 5 hands hand NNS cord-009571-mygj2nd4 1621 6 , , , cord-009571-mygj2nd4 1621 7 at at IN cord-009571-mygj2nd4 1621 8 times time NNS cord-009571-mygj2nd4 1621 9 massive massive JJ cord-009571-mygj2nd4 1621 10 , , , cord-009571-mygj2nd4 1621 11 was be VBD cord-009571-mygj2nd4 1621 12 noted note VBN cord-009571-mygj2nd4 1621 13 in in IN cord-009571-mygj2nd4 1621 14 4 4 CD cord-009571-mygj2nd4 1621 15 of of IN cord-009571-mygj2nd4 1621 16 5 5 CD cord-009571-mygj2nd4 1621 17 . . . cord-009571-mygj2nd4 1622 1 Knee knee NN cord-009571-mygj2nd4 1622 2 and and CC cord-009571-mygj2nd4 1622 3 elbow elbow NN cord-009571-mygj2nd4 1622 4 effusions effusion NNS cord-009571-mygj2nd4 1622 5 were be VBD cord-009571-mygj2nd4 1622 6 present present JJ cord-009571-mygj2nd4 1622 7 in in IN cord-009571-mygj2nd4 1622 8 2 2 CD cord-009571-mygj2nd4 1622 9 patients patient NNS cord-009571-mygj2nd4 1622 10 . . . cord-009571-mygj2nd4 1623 1 Sedimen sedimen NN cord-009571-mygj2nd4 1623 2 - - HYPH cord-009571-mygj2nd4 1623 3 tation tation NN cord-009571-mygj2nd4 1623 4 rates rate NNS cord-009571-mygj2nd4 1623 5 , , , cord-009571-mygj2nd4 1623 6 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1623 7 factor factor NN cord-009571-mygj2nd4 1623 8 , , , cord-009571-mygj2nd4 1623 9 and and CC cord-009571-mygj2nd4 1623 10 antinuclear antinuclear JJ cord-009571-mygj2nd4 1623 11 antibodies antibody NNS cord-009571-mygj2nd4 1623 12 were be VBD cord-009571-mygj2nd4 1623 13 normal normal JJ cord-009571-mygj2nd4 1623 14 or or CC cord-009571-mygj2nd4 1623 15 negative negative JJ cord-009571-mygj2nd4 1623 16 . . . cord-009571-mygj2nd4 1624 1 Serum serum NN cord-009571-mygj2nd4 1624 2 and and CC cord-009571-mygj2nd4 1624 3 urine urine NN cord-009571-mygj2nd4 1624 4 protein protein NN cord-009571-mygj2nd4 1624 5 electrophoresis electrophoresis NN cord-009571-mygj2nd4 1624 6 and and CC cord-009571-mygj2nd4 1624 7 immunoelectrophoresis immunoelectrophoresis NN cord-009571-mygj2nd4 1624 8 failed fail VBD cord-009571-mygj2nd4 1624 9 to to TO cord-009571-mygj2nd4 1624 10 detect detect VB cord-009571-mygj2nd4 1624 11 any any DT cord-009571-mygj2nd4 1624 12 paraprotein paraprotein NNS cord-009571-mygj2nd4 1624 13 . . . cord-009571-mygj2nd4 1625 1 joint joint JJ cord-009571-mygj2nd4 1625 2 fluids fluid NNS cord-009571-mygj2nd4 1625 3 ( ( -LRB- cord-009571-mygj2nd4 1625 4 4 4 CD cord-009571-mygj2nd4 1625 5 ) ) -RRB- cord-009571-mygj2nd4 1625 6 were be VBD cord-009571-mygj2nd4 1625 7 noninflammatory noninflammatory JJ cord-009571-mygj2nd4 1625 8 except except IN cord-009571-mygj2nd4 1625 9 for for IN cord-009571-mygj2nd4 1625 10 one one CD cord-009571-mygj2nd4 1625 11 aspirated aspirate VBN cord-009571-mygj2nd4 1625 12 during during IN cord-009571-mygj2nd4 1625 13 an an DT cord-009571-mygj2nd4 1625 14 acute acute JJ cord-009571-mygj2nd4 1625 15 attack attack NN cord-009571-mygj2nd4 1625 16 of of IN cord-009571-mygj2nd4 1625 17 pseudogout pseudogout NN cord-009571-mygj2nd4 1625 18 . . . cord-009571-mygj2nd4 1626 1 Radiographs radiograph NNS cord-009571-mygj2nd4 1626 2 showed show VBD cord-009571-mygj2nd4 1626 3 degenerative degenerative JJ cord-009571-mygj2nd4 1626 4 changes change NNS cord-009571-mygj2nd4 1626 5 ( ( -LRB- cord-009571-mygj2nd4 1626 6 3 3 CD cord-009571-mygj2nd4 1626 7 : : SYM cord-009571-mygj2nd4 1626 8 5 5 LS cord-009571-mygj2nd4 1626 9 ) ) -RRB- cord-009571-mygj2nd4 1626 10 and and CC cord-009571-mygj2nd4 1626 11 chondrocalcinosis chondrocalcinosis NNP cord-009571-mygj2nd4 1626 12 ( ( -LRB- cord-009571-mygj2nd4 1626 13 4 4 CD cord-009571-mygj2nd4 1626 14 : : SYM cord-009571-mygj2nd4 1626 15 5 5 CD cord-009571-mygj2nd4 1626 16 ) ) -RRB- cord-009571-mygj2nd4 1626 17 . . . cord-009571-mygj2nd4 1627 1 Synovium Synovium NNP cord-009571-mygj2nd4 1627 2 obtained obtain VBN cord-009571-mygj2nd4 1627 3 by by IN cord-009571-mygj2nd4 1627 4 open open JJ cord-009571-mygj2nd4 1627 5 biopsy biopsy NN cord-009571-mygj2nd4 1627 6 ( ( -LRB- cord-009571-mygj2nd4 1627 7 5 5 CD cord-009571-mygj2nd4 1627 8 : : SYM cord-009571-mygj2nd4 1627 9 5 5 LS cord-009571-mygj2nd4 1627 10 ) ) -RRB- cord-009571-mygj2nd4 1627 11 revealed reveal VBD cord-009571-mygj2nd4 1627 12 deposits deposit NNS cord-009571-mygj2nd4 1627 13 of of IN cord-009571-mygj2nd4 1627 14 material material NN cord-009571-mygj2nd4 1627 15 which which WDT cord-009571-mygj2nd4 1627 16 displayed display VBD cord-009571-mygj2nd4 1627 17 metachromasia metachromasia NNP cord-009571-mygj2nd4 1627 18 after after IN cord-009571-mygj2nd4 1627 19 crystal crystal NN cord-009571-mygj2nd4 1627 20 violet violet NN cord-009571-mygj2nd4 1627 21 staining staining NN cord-009571-mygj2nd4 1627 22 . . . cord-009571-mygj2nd4 1628 1 In in IN cord-009571-mygj2nd4 1628 2 3 3 CD cord-009571-mygj2nd4 1628 3 cases case NNS cord-009571-mygj2nd4 1628 4 , , , cord-009571-mygj2nd4 1628 5 electron electron NN cord-009571-mygj2nd4 1628 6 microscopy microscopy NN cord-009571-mygj2nd4 1628 7 was be VBD cord-009571-mygj2nd4 1628 8 performed perform VBN cord-009571-mygj2nd4 1628 9 and and CC cord-009571-mygj2nd4 1628 10 revealed reveal VBN cord-009571-mygj2nd4 1628 11 typical typical JJ cord-009571-mygj2nd4 1628 12 fibrils fibril NNS cord-009571-mygj2nd4 1628 13 in in IN cord-009571-mygj2nd4 1628 14 synovium synovium NNP cord-009571-mygj2nd4 1628 15 . . . cord-009571-mygj2nd4 1629 1 Deposits deposit NNS cord-009571-mygj2nd4 1629 2 were be VBD cord-009571-mygj2nd4 1629 3 localized localize VBN cord-009571-mygj2nd4 1629 4 to to IN cord-009571-mygj2nd4 1629 5 perivascular perivascular JJ cord-009571-mygj2nd4 1629 6 and and CC cord-009571-mygj2nd4 1629 7 subsynovial subsynovial JJ cord-009571-mygj2nd4 1629 8 locations location NNS cord-009571-mygj2nd4 1629 9 . . . cord-009571-mygj2nd4 1630 1 Attention attention NN cord-009571-mygj2nd4 1630 2 is be VBZ cord-009571-mygj2nd4 1630 3 called call VBN cord-009571-mygj2nd4 1630 4 to to IN cord-009571-mygj2nd4 1630 5 the the DT cord-009571-mygj2nd4 1630 6 presentation presentation NN cord-009571-mygj2nd4 1630 7 of of IN cord-009571-mygj2nd4 1630 8 AA AA NNP cord-009571-mygj2nd4 1630 9 as as IN cord-009571-mygj2nd4 1630 10 edema edema NN cord-009571-mygj2nd4 1630 11 of of IN cord-009571-mygj2nd4 1630 12 the the DT cord-009571-mygj2nd4 1630 13 hands hand NNS cord-009571-mygj2nd4 1630 14 with with IN cord-009571-mygj2nd4 1630 15 or or CC cord-009571-mygj2nd4 1630 16 without without IN cord-009571-mygj2nd4 1630 17 median median JJ cord-009571-mygj2nd4 1630 18 nerve nerve NN cord-009571-mygj2nd4 1630 19 compression compression NN cord-009571-mygj2nd4 1630 20 . . . cord-009571-mygj2nd4 1631 1 Edematous Edematous NNP cord-009571-mygj2nd4 1631 2 hands hand NNS cord-009571-mygj2nd4 1631 3 and and CC cord-009571-mygj2nd4 1631 4 seronegative seronegative JJ cord-009571-mygj2nd4 1631 5 arthritis arthritis NN cord-009571-mygj2nd4 1631 6 should should MD cord-009571-mygj2nd4 1631 7 raise raise VB cord-009571-mygj2nd4 1631 8 the the DT cord-009571-mygj2nd4 1631 9 possibility possibility NN cord-009571-mygj2nd4 1631 10 of of IN cord-009571-mygj2nd4 1631 11 AA AA NNP cord-009571-mygj2nd4 1631 12 . . . cord-009571-mygj2nd4 1632 1 These these DT cord-009571-mygj2nd4 1632 2 patients patient NNS cord-009571-mygj2nd4 1632 3 are be VBP cord-009571-mygj2nd4 1632 4 also also RB cord-009571-mygj2nd4 1632 5 unusual unusual JJ cord-009571-mygj2nd4 1632 6 in in IN cord-009571-mygj2nd4 1632 7 that that DT cord-009571-mygj2nd4 1632 8 AA AA NNP cord-009571-mygj2nd4 1632 9 was be VBD cord-009571-mygj2nd4 1632 10 not not RB cord-009571-mygj2nd4 1632 11 associated associate VBN cord-009571-mygj2nd4 1632 12 with with IN cord-009571-mygj2nd4 1632 13 dysproteinemia dysproteinemia NN cord-009571-mygj2nd4 1632 14 and and CC cord-009571-mygj2nd4 1632 15 absence absence NN cord-009571-mygj2nd4 1632 16 of of IN cord-009571-mygj2nd4 1632 17 a a DT cord-009571-mygj2nd4 1632 18 paraprotein paraprotein NNP cord-009571-mygj2nd4 1632 19 should should MD cord-009571-mygj2nd4 1632 20 not not RB cord-009571-mygj2nd4 1632 21 discourage discourage VB cord-009571-mygj2nd4 1632 22 invasive invasive JJ cord-009571-mygj2nd4 1632 23 measures measure NNS cord-009571-mygj2nd4 1632 24 to to TO cord-009571-mygj2nd4 1632 25 document document VB cord-009571-mygj2nd4 1632 26 AA AA NNP cord-009571-mygj2nd4 1632 27 . . . cord-009571-mygj2nd4 1633 1 The the DT cord-009571-mygj2nd4 1633 2 associated associated JJ cord-009571-mygj2nd4 1633 3 chondrocalcinosis chondrocalcinosis NN cord-009571-mygj2nd4 1633 4 has have VBZ cord-009571-mygj2nd4 1633 5 been be VBN cord-009571-mygj2nd4 1633 6 previously previously RB cord-009571-mygj2nd4 1633 7 recognized recognize VBN cord-009571-mygj2nd4 1633 8 in in IN cord-009571-mygj2nd4 1633 9 only only RB cord-009571-mygj2nd4 1633 10 one one CD cord-009571-mygj2nd4 1633 11 case case NN cord-009571-mygj2nd4 1633 12 report report NN cord-009571-mygj2nd4 1633 13 . . . cord-009571-mygj2nd4 1634 1 Chondrocalcinosis Chondrocalcinosis NNP cord-009571-mygj2nd4 1634 2 in in IN cord-009571-mygj2nd4 1634 3 4 4 CD cord-009571-mygj2nd4 1634 4 of of IN cord-009571-mygj2nd4 1634 5 5 5 CD cord-009571-mygj2nd4 1634 6 patients patient NNS cord-009571-mygj2nd4 1634 7 may may MD cord-009571-mygj2nd4 1634 8 be be VB cord-009571-mygj2nd4 1634 9 a a DT cord-009571-mygj2nd4 1634 10 chance chance NN cord-009571-mygj2nd4 1634 11 occurrence occurrence NN cord-009571-mygj2nd4 1634 12 in in IN cord-009571-mygj2nd4 1634 13 an an DT cord-009571-mygj2nd4 1634 14 elderly elderly JJ cord-009571-mygj2nd4 1634 15 population population NN cord-009571-mygj2nd4 1634 16 ( ( -LRB- cord-009571-mygj2nd4 1634 17 age age NN cord-009571-mygj2nd4 1634 18 range range NN cord-009571-mygj2nd4 1634 19 67 67 CD cord-009571-mygj2nd4 1634 20 - - SYM cord-009571-mygj2nd4 1634 21 90 90 CD cord-009571-mygj2nd4 1634 22 ) ) -RRB- cord-009571-mygj2nd4 1634 23 or or CC cord-009571-mygj2nd4 1634 24 may may MD cord-009571-mygj2nd4 1634 25 cause cause VB cord-009571-mygj2nd4 1634 26 AA AA NNP cord-009571-mygj2nd4 1634 27 by by IN cord-009571-mygj2nd4 1634 28 chronic chronic JJ cord-009571-mygj2nd4 1634 29 local local JJ cord-009571-mygj2nd4 1634 30 inflammation inflammation NN cord-009571-mygj2nd4 1634 31 . . . cord-009571-mygj2nd4 1635 1 Antimalarial antimalarial JJ cord-009571-mygj2nd4 1635 2 therapy therapy NN cord-009571-mygj2nd4 1635 3 for for IN cord-009571-mygj2nd4 1635 4 connective connective JJ cord-009571-mygj2nd4 1635 5 tissue tissue NN cord-009571-mygj2nd4 1635 6 disease disease NN cord-009571-mygj2nd4 1635 7 has have VBZ cord-009571-mygj2nd4 1635 8 been be VBN cord-009571-mygj2nd4 1635 9 limited limit VBN cord-009571-mygj2nd4 1635 10 by by IN cord-009571-mygj2nd4 1635 11 its -PRON- PRP$ cord-009571-mygj2nd4 1635 12 potential potential JJ cord-009571-mygj2nd4 1635 13 retinal retinal JJ cord-009571-mygj2nd4 1635 14 toxicity toxicity NN cord-009571-mygj2nd4 1635 15 . . . cord-009571-mygj2nd4 1636 1 The the DT cord-009571-mygj2nd4 1636 2 present present JJ cord-009571-mygj2nd4 1636 3 study study NN cord-009571-mygj2nd4 1636 4 was be VBD cord-009571-mygj2nd4 1636 5 undertaken undertake VBN cord-009571-mygj2nd4 1636 6 to to TO cord-009571-mygj2nd4 1636 7 assess assess VB cord-009571-mygj2nd4 1636 8 visual visual JJ cord-009571-mygj2nd4 1636 9 problems problem NNS cord-009571-mygj2nd4 1636 10 in in IN cord-009571-mygj2nd4 1636 11 patients patient NNS cord-009571-mygj2nd4 1636 12 treated treat VBN cord-009571-mygj2nd4 1636 13 with with IN cord-009571-mygj2nd4 1636 14 long long JJ cord-009571-mygj2nd4 1636 15 - - HYPH cord-009571-mygj2nd4 1636 16 term term NN cord-009571-mygj2nd4 1636 17 hydroxychloroquine hydroxychloroquine NN cord-009571-mygj2nd4 1636 18 given give VBN cord-009571-mygj2nd4 1636 19 in in IN cord-009571-mygj2nd4 1636 20 standard standard JJ cord-009571-mygj2nd4 1636 21 dosage dosage NN cord-009571-mygj2nd4 1636 22 . . . cord-009571-mygj2nd4 1637 1 All all DT cord-009571-mygj2nd4 1637 2 patients patient NNS cord-009571-mygj2nd4 1637 3 who who WP cord-009571-mygj2nd4 1637 4 received receive VBD cord-009571-mygj2nd4 1637 5 both both DT cord-009571-mygj2nd4 1637 6 treatment treatment NN cord-009571-mygj2nd4 1637 7 and and CC cord-009571-mygj2nd4 1637 8 ophthalmologic ophthalmologic NN cord-009571-mygj2nd4 1637 9 evaluation evaluation NN cord-009571-mygj2nd4 1637 10 a a DT cord-009571-mygj2nd4 1637 11 t t NN cord-009571-mygj2nd4 1637 12 Albany Albany NNP cord-009571-mygj2nd4 1637 13 Medical Medical NNP cord-009571-mygj2nd4 1637 14 College College NNP cord-009571-mygj2nd4 1637 15 were be VBD cord-009571-mygj2nd4 1637 16 included include VBN cord-009571-mygj2nd4 1637 17 and and CC cord-009571-mygj2nd4 1637 18 consisted consist VBN cord-009571-mygj2nd4 1637 19 of of IN cord-009571-mygj2nd4 1637 20 99 99 CD cord-009571-mygj2nd4 1637 21 patients patient NNS cord-009571-mygj2nd4 1637 22 treated treat VBN cord-009571-mygj2nd4 1637 23 for for IN cord-009571-mygj2nd4 1637 24 a a DT cord-009571-mygj2nd4 1637 25 t t NN cord-009571-mygj2nd4 1637 26 least least JJS cord-009571-mygj2nd4 1637 27 1 1 CD cord-009571-mygj2nd4 1637 28 year year NN cord-009571-mygj2nd4 1637 29 . . . cord-009571-mygj2nd4 1638 1 Each each DT cord-009571-mygj2nd4 1638 2 patient patient NN cord-009571-mygj2nd4 1638 3 was be VBD cord-009571-mygj2nd4 1638 4 examined examine VBN cord-009571-mygj2nd4 1638 5 a a DT cord-009571-mygj2nd4 1638 6 t t NN cord-009571-mygj2nd4 1638 7 baseline baseline NN cord-009571-mygj2nd4 1639 1 and and CC cord-009571-mygj2nd4 1639 2 then then RB cord-009571-mygj2nd4 1639 3 every every DT cord-009571-mygj2nd4 1639 4 6 6 CD cord-009571-mygj2nd4 1639 5 months month NNS cord-009571-mygj2nd4 1639 6 for for IN cord-009571-mygj2nd4 1639 7 visual visual JJ cord-009571-mygj2nd4 1639 8 acuity acuity NN cord-009571-mygj2nd4 1639 9 , , , cord-009571-mygj2nd4 1639 10 central central JJ cord-009571-mygj2nd4 1639 11 fields field NNS cord-009571-mygj2nd4 1639 12 using use VBG cord-009571-mygj2nd4 1639 13 a a DT cord-009571-mygj2nd4 1639 14 red red JJ cord-009571-mygj2nd4 1639 15 test test NN cord-009571-mygj2nd4 1639 16 object object NN cord-009571-mygj2nd4 1639 17 , , , cord-009571-mygj2nd4 1639 18 funduscopic funduscopic NNP cord-009571-mygj2nd4 1639 19 abnormalities abnormality NNS cord-009571-mygj2nd4 1639 20 , , , cord-009571-mygj2nd4 1639 21 accommodation accommodation NN cord-009571-mygj2nd4 1639 22 , , , cord-009571-mygj2nd4 1639 23 corneal corneal JJ cord-009571-mygj2nd4 1639 24 deposits deposit NNS cord-009571-mygj2nd4 1639 25 using use VBG cord-009571-mygj2nd4 1639 26 a a DT cord-009571-mygj2nd4 1639 27 slit slit JJ cord-009571-mygj2nd4 1639 28 lamp lamp NN cord-009571-mygj2nd4 1639 29 , , , cord-009571-mygj2nd4 1639 30 and and CC cord-009571-mygj2nd4 1639 31 keratoconjunctivitis keratoconjunctivitis NNP cord-009571-mygj2nd4 1639 32 by by IN cord-009571-mygj2nd4 1639 33 Shirmer Shirmer NNP cord-009571-mygj2nd4 1639 34 test test NN cord-009571-mygj2nd4 1639 35 . . . cord-009571-mygj2nd4 1640 1 Electro Electro NNP cord-009571-mygj2nd4 1640 2 - - HYPH cord-009571-mygj2nd4 1640 3 oculograms oculograms NNP cord-009571-mygj2nd4 1640 4 ( ( -LRB- cord-009571-mygj2nd4 1640 5 EOG EOG NNP cord-009571-mygj2nd4 1640 6 ) ) -RRB- cord-009571-mygj2nd4 1640 7 were be VBD cord-009571-mygj2nd4 1640 8 performed perform VBN cord-009571-mygj2nd4 1640 9 in in IN cord-009571-mygj2nd4 1640 10 14 14 CD cord-009571-mygj2nd4 1640 11 patients patient NNS cord-009571-mygj2nd4 1640 12 who who WP cord-009571-mygj2nd4 1640 13 had have VBD cord-009571-mygj2nd4 1640 14 received receive VBN cord-009571-mygj2nd4 1640 15 high high JJ cord-009571-mygj2nd4 1640 16 total total JJ cord-009571-mygj2nd4 1640 17 doses dose NNS cord-009571-mygj2nd4 1640 18 or or CC cord-009571-mygj2nd4 1640 19 had have VBD cord-009571-mygj2nd4 1640 20 abnormal abnormal JJ cord-009571-mygj2nd4 1640 21 central central JJ cord-009571-mygj2nd4 1640 22 fields field NNS cord-009571-mygj2nd4 1640 23 suggesting suggest VBG cord-009571-mygj2nd4 1640 24 toxicity toxicity NN cord-009571-mygj2nd4 1640 25 . . . cord-009571-mygj2nd4 1641 1 Almost almost RB cord-009571-mygj2nd4 1641 2 all all DT cord-009571-mygj2nd4 1641 3 patients patient NNS cord-009571-mygj2nd4 1641 4 received receive VBD cord-009571-mygj2nd4 1641 5 hydroxychloroquine hydroxychloroquine NN cord-009571-mygj2nd4 1641 6 in in IN cord-009571-mygj2nd4 1641 7 the the DT cord-009571-mygj2nd4 1641 8 maximal maximal JJ cord-009571-mygj2nd4 1641 9 daily daily JJ cord-009571-mygj2nd4 1641 10 dose dose NN cord-009571-mygj2nd4 1641 11 of of IN cord-009571-mygj2nd4 1641 12 400 400 CD cord-009571-mygj2nd4 1641 13 mg mg NN cord-009571-mygj2nd4 1641 14 . . . cord-009571-mygj2nd4 1642 1 Total total JJ cord-009571-mygj2nd4 1642 2 dose dose NN cord-009571-mygj2nd4 1642 3 ranged range VBD cord-009571-mygj2nd4 1642 4 from from IN cord-009571-mygj2nd4 1642 5 146 146 CD cord-009571-mygj2nd4 1642 6 to to IN cord-009571-mygj2nd4 1642 7 927 927 CD cord-009571-mygj2nd4 1642 8 g g NN cord-009571-mygj2nd4 1642 9 ( ( -LRB- cord-009571-mygj2nd4 1642 10 median median NN cord-009571-mygj2nd4 1642 11 365 365 CD cord-009571-mygj2nd4 1642 12 ) ) -RRB- cord-009571-mygj2nd4 1642 13 and and CC cord-009571-mygj2nd4 1642 14 duration duration NN cord-009571-mygj2nd4 1642 15 of of IN cord-009571-mygj2nd4 1642 16 treatment treatment NN cord-009571-mygj2nd4 1642 17 from from IN cord-009571-mygj2nd4 1642 18 13 13 CD cord-009571-mygj2nd4 1642 19 to to TO cord-009571-mygj2nd4 1642 20 68 68 CD cord-009571-mygj2nd4 1642 21 months month NNS cord-009571-mygj2nd4 1642 22 ( ( -LRB- cord-009571-mygj2nd4 1642 23 median median JJ cord-009571-mygj2nd4 1642 24 33 33 CD cord-009571-mygj2nd4 1642 25 ) ) -RRB- cord-009571-mygj2nd4 1642 26 . . . cord-009571-mygj2nd4 1643 1 Diseases disease NNS cord-009571-mygj2nd4 1643 2 treated treat VBN cord-009571-mygj2nd4 1643 3 were be VBD cord-009571-mygj2nd4 1643 4 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 1643 5 arthritis arthritis NN cord-009571-mygj2nd4 1643 6 in in IN cord-009571-mygj2nd4 1643 7 58 58 CD cord-009571-mygj2nd4 1643 8 patients patient NNS cord-009571-mygj2nd4 1643 9 , , , cord-009571-mygj2nd4 1643 10 systemic systemic JJ cord-009571-mygj2nd4 1643 11 lupus lupus NN cord-009571-mygj2nd4 1643 12 erythematosus erythematosus NN cord-009571-mygj2nd4 1643 13 in in IN cord-009571-mygj2nd4 1643 14 31 31 CD cord-009571-mygj2nd4 1643 15 , , , cord-009571-mygj2nd4 1643 16 juvenile juvenile JJ cord-009571-mygj2nd4 1643 17 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1643 18 arthritis arthritis NN cord-009571-mygj2nd4 1643 19 in in IN cord-009571-mygj2nd4 1643 20 4 4 CD cord-009571-mygj2nd4 1643 21 , , , cord-009571-mygj2nd4 1643 22 mixed mixed JJ cord-009571-mygj2nd4 1643 23 connective connective JJ cord-009571-mygj2nd4 1643 24 tissue tissue NN cord-009571-mygj2nd4 1643 25 disease disease NN cord-009571-mygj2nd4 1643 26 in in IN cord-009571-mygj2nd4 1643 27 2 2 CD cord-009571-mygj2nd4 1643 28 , , , cord-009571-mygj2nd4 1643 29 and and CC cord-009571-mygj2nd4 1643 30 other other JJ cord-009571-mygj2nd4 1643 31 in in IN cord-009571-mygj2nd4 1643 32 4 4 CD cord-009571-mygj2nd4 1643 33 . . . cord-009571-mygj2nd4 1644 1 Ophthalmologic Ophthalmologic NNP cord-009571-mygj2nd4 1644 2 toxicity toxicity NN cord-009571-mygj2nd4 1644 3 was be VBD cord-009571-mygj2nd4 1644 4 minimal minimal JJ cord-009571-mygj2nd4 1644 5 . . . cord-009571-mygj2nd4 1645 1 No no DT cord-009571-mygj2nd4 1645 2 patients patient NNS cord-009571-mygj2nd4 1645 3 were be VBD cord-009571-mygj2nd4 1645 4 precluded preclude VBN cord-009571-mygj2nd4 1645 5 from from IN cord-009571-mygj2nd4 1645 6 taking take VBG cord-009571-mygj2nd4 1645 7 hydroxychloroquine hydroxychloroquine NNP cord-009571-mygj2nd4 1645 8 at at IN cord-009571-mygj2nd4 1645 9 baseline baseline JJ cord-009571-mygj2nd4 1645 10 evaluation evaluation NN cord-009571-mygj2nd4 1645 11 . . . cord-009571-mygj2nd4 1646 1 No no DT cord-009571-mygj2nd4 1646 2 corneal corneal JJ cord-009571-mygj2nd4 1646 3 deposits deposit NNS cord-009571-mygj2nd4 1646 4 or or CC cord-009571-mygj2nd4 1646 5 accommodation accommodation NN cord-009571-mygj2nd4 1646 6 defects defect NNS cord-009571-mygj2nd4 1646 7 were be VBD cord-009571-mygj2nd4 1646 8 found find VBN cord-009571-mygj2nd4 1646 9 . . . cord-009571-mygj2nd4 1647 1 Three three CD cord-009571-mygj2nd4 1647 2 patients patient NNS cord-009571-mygj2nd4 1647 3 had have VBD cord-009571-mygj2nd4 1647 4 abnormalities abnormality NNS cord-009571-mygj2nd4 1647 5 in in IN cord-009571-mygj2nd4 1647 6 central central JJ cord-009571-mygj2nd4 1647 7 fields field NNS cord-009571-mygj2nd4 1647 8 : : : cord-009571-mygj2nd4 1647 9 paracentral paracentral NNP cord-009571-mygj2nd4 1647 10 scotomata scotomata NNP cord-009571-mygj2nd4 1647 11 and/or and/or CC cord-009571-mygj2nd4 1647 12 minor minor JJ cord-009571-mygj2nd4 1647 13 field field NN cord-009571-mygj2nd4 1647 14 restrictions restriction NNS cord-009571-mygj2nd4 1647 15 . . . cord-009571-mygj2nd4 1648 1 All all DT cord-009571-mygj2nd4 1648 2 3 3 CD cord-009571-mygj2nd4 1648 3 had have VBD cord-009571-mygj2nd4 1648 4 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 1648 5 arthritis arthritis NN cord-009571-mygj2nd4 1648 6 . . . cord-009571-mygj2nd4 1649 1 Toxicity toxicity NN cord-009571-mygj2nd4 1649 2 occurred occur VBD cord-009571-mygj2nd4 1649 3 after after IN cord-009571-mygj2nd4 1649 4 total total JJ cord-009571-mygj2nd4 1649 5 doses dose NNS cord-009571-mygj2nd4 1649 6 of of IN cord-009571-mygj2nd4 1649 7 73 73 CD cord-009571-mygj2nd4 1649 8 , , , cord-009571-mygj2nd4 1649 9 206 206 CD cord-009571-mygj2nd4 1649 10 , , , cord-009571-mygj2nd4 1649 11 and and CC cord-009571-mygj2nd4 1649 12 316 316 CD cord-009571-mygj2nd4 1649 13 g. g. NN cord-009571-mygj2nd4 1649 14 Visual visual JJ cord-009571-mygj2nd4 1649 15 changes change NNS cord-009571-mygj2nd4 1649 16 were be VBD cord-009571-mygj2nd4 1649 17 completely completely RB cord-009571-mygj2nd4 1649 18 reversible reversible JJ cord-009571-mygj2nd4 1649 19 in in IN cord-009571-mygj2nd4 1649 20 the the DT cord-009571-mygj2nd4 1649 21 first first JJ cord-009571-mygj2nd4 1649 22 patient patient NN cord-009571-mygj2nd4 1649 23 who who WP cord-009571-mygj2nd4 1649 24 was be VBD cord-009571-mygj2nd4 1649 25 the the DT cord-009571-mygj2nd4 1649 26 only only JJ cord-009571-mygj2nd4 1649 27 one one CD cord-009571-mygj2nd4 1649 28 in in IN cord-009571-mygj2nd4 1649 29 the the DT cord-009571-mygj2nd4 1649 30 series series NN cord-009571-mygj2nd4 1649 31 with with IN cord-009571-mygj2nd4 1649 32 funduscopic funduscopic NNP cord-009571-mygj2nd4 1649 33 changes change NNS cord-009571-mygj2nd4 1649 34 . . . cord-009571-mygj2nd4 1650 1 She -PRON- PRP cord-009571-mygj2nd4 1650 2 has have VBZ cord-009571-mygj2nd4 1650 3 now now RB cord-009571-mygj2nd4 1650 4 received receive VBN cord-009571-mygj2nd4 1650 5 a a DT cord-009571-mygj2nd4 1650 6 total total JJ cord-009571-mygj2nd4 1650 7 dose dose NN cord-009571-mygj2nd4 1650 8 of of IN cord-009571-mygj2nd4 1650 9 535 535 CD cord-009571-mygj2nd4 1650 10 g g NN cord-009571-mygj2nd4 1650 11 and and CC cord-009571-mygj2nd4 1650 12 has have VBZ cord-009571-mygj2nd4 1650 13 normal normal JJ cord-009571-mygj2nd4 1650 14 fundi fundus NNS cord-009571-mygj2nd4 1650 15 , , , cord-009571-mygj2nd4 1650 16 central central JJ cord-009571-mygj2nd4 1650 17 fields field NNS cord-009571-mygj2nd4 1650 18 , , , cord-009571-mygj2nd4 1650 19 and and CC cord-009571-mygj2nd4 1650 20 EOG EOG NNP cord-009571-mygj2nd4 1650 21 . . . cord-009571-mygj2nd4 1651 1 The the DT cord-009571-mygj2nd4 1651 2 second second JJ cord-009571-mygj2nd4 1651 3 patient patient NN cord-009571-mygj2nd4 1651 4 continues continue VBZ cord-009571-mygj2nd4 1651 5 to to TO cord-009571-mygj2nd4 1651 6 have have VB cord-009571-mygj2nd4 1651 7 central central JJ cord-009571-mygj2nd4 1651 8 field field NN cord-009571-mygj2nd4 1651 9 restriction restriction NN cord-009571-mygj2nd4 1651 10 but but CC cord-009571-mygj2nd4 1651 11 has have VBZ cord-009571-mygj2nd4 1651 12 had have VBN cord-009571-mygj2nd4 1651 13 resolution resolution NN cord-009571-mygj2nd4 1651 14 of of IN cord-009571-mygj2nd4 1651 15 paracentral paracentral JJ cord-009571-mygj2nd4 1651 16 scotomata scotomata NNP cord-009571-mygj2nd4 1651 17 , , , cord-009571-mygj2nd4 1651 18 a a DT cord-009571-mygj2nd4 1651 19 normal normal JJ cord-009571-mygj2nd4 1651 20 EOG EOG NNP cord-009571-mygj2nd4 1651 21 , , , cord-009571-mygj2nd4 1651 22 and and CC cord-009571-mygj2nd4 1651 23 no no DT cord-009571-mygj2nd4 1651 24 visual visual JJ cord-009571-mygj2nd4 1651 25 complaints complaint NNS cord-009571-mygj2nd4 1651 26 . . . cord-009571-mygj2nd4 1652 1 The the DT cord-009571-mygj2nd4 1652 2 third third JJ cord-009571-mygj2nd4 1652 3 had have VBD cord-009571-mygj2nd4 1652 4 reversal reversal NN cord-009571-mygj2nd4 1652 5 of of IN cord-009571-mygj2nd4 1652 6 central central JJ cord-009571-mygj2nd4 1652 7 field field NN cord-009571-mygj2nd4 1652 8 defects defect NNS cord-009571-mygj2nd4 1652 9 but but CC cord-009571-mygj2nd4 1652 10 had have VBD cord-009571-mygj2nd4 1652 11 an an DT cord-009571-mygj2nd4 1652 12 abnormal abnormal JJ cord-009571-mygj2nd4 1652 13 EOG eog NN cord-009571-mygj2nd4 1652 14 when when WRB cord-009571-mygj2nd4 1652 15 subsequently subsequently RB cord-009571-mygj2nd4 1652 16 tested test VBD cord-009571-mygj2nd4 1652 17 . . . cord-009571-mygj2nd4 1653 1 We -PRON- PRP cord-009571-mygj2nd4 1653 2 conclude conclude VBP cord-009571-mygj2nd4 1653 3 that that IN cord-009571-mygj2nd4 1653 4 hydroxychloroquine hydroxychloroquine NN cord-009571-mygj2nd4 1653 5 in in IN cord-009571-mygj2nd4 1653 6 a a DT cord-009571-mygj2nd4 1653 7 dosage dosage NN cord-009571-mygj2nd4 1653 8 of of IN cord-009571-mygj2nd4 1653 9 400 400 CD cord-009571-mygj2nd4 1653 10 mg mg NNP cord-009571-mygj2nd4 1653 11 / / SYM cord-009571-mygj2nd4 1653 12 day day NN cord-009571-mygj2nd4 1653 13 is be VBZ cord-009571-mygj2nd4 1653 14 safe safe JJ cord-009571-mygj2nd4 1653 15 from from IN cord-009571-mygj2nd4 1653 16 significant significant JJ cord-009571-mygj2nd4 1653 17 ophthalmologic ophthalmologic JJ cord-009571-mygj2nd4 1653 18 toxicity toxicity NN cord-009571-mygj2nd4 1653 19 if if IN cord-009571-mygj2nd4 1653 20 followed follow VBN cord-009571-mygj2nd4 1653 21 by by IN cord-009571-mygj2nd4 1653 22 appropriate appropriate JJ cord-009571-mygj2nd4 1653 23 testing testing NN cord-009571-mygj2nd4 1653 24 , , , cord-009571-mygj2nd4 1653 25 and and CC cord-009571-mygj2nd4 1653 26 we -PRON- PRP cord-009571-mygj2nd4 1653 27 find find VBP cord-009571-mygj2nd4 1653 28 n n NN cord-009571-mygj2nd4 1653 29 o o NN cord-009571-mygj2nd4 1653 30 evidence evidence NN cord-009571-mygj2nd4 1653 31 from from IN cord-009571-mygj2nd4 1653 32 an an DT cord-009571-mygj2nd4 1653 33 association association NN cord-009571-mygj2nd4 1653 34 of of IN cord-009571-mygj2nd4 1653 35 increased increase VBN cord-009571-mygj2nd4 1653 36 toxicity toxicity NN cord-009571-mygj2nd4 1653 37 with with IN cord-009571-mygj2nd4 1653 38 higher high JJR cord-009571-mygj2nd4 1653 39 total total JJ cord-009571-mygj2nd4 1653 40 dose dose NN cord-009571-mygj2nd4 1653 41 or or CC cord-009571-mygj2nd4 1653 42 with with IN cord-009571-mygj2nd4 1653 43 the the DT cord-009571-mygj2nd4 1653 44 diagnosis diagnosis NN cord-009571-mygj2nd4 1653 45 of of IN cord-009571-mygj2nd4 1653 46 systemic systemic JJ cord-009571-mygj2nd4 1653 47 lupus lupus NN cord-009571-mygj2nd4 1653 48 erythematosus erythematosus NN cord-009571-mygj2nd4 1653 49 . . . cord-009571-mygj2nd4 1654 1 The the DT cord-009571-mygj2nd4 1654 2 metal metal NN cord-009571-mygj2nd4 1654 3 - - HYPH cord-009571-mygj2nd4 1654 4 dependent dependent JJ cord-009571-mygj2nd4 1654 5 neutral neutral JJ cord-009571-mygj2nd4 1654 6 proteoglycanase proteoglycanase NN cord-009571-mygj2nd4 1654 7 , , , cord-009571-mygj2nd4 1654 8 extracted extract VBN cord-009571-mygj2nd4 1654 9 from from IN cord-009571-mygj2nd4 1654 10 1,200 1,200 CD cord-009571-mygj2nd4 1654 11 grams gram NNS cord-009571-mygj2nd4 1654 12 of of IN cord-009571-mygj2nd4 1654 13 human human JJ cord-009571-mygj2nd4 1654 14 articular articular JJ cord-009571-mygj2nd4 1654 15 cartilage cartilage NN cord-009571-mygj2nd4 1654 16 , , , cord-009571-mygj2nd4 1654 17 occurred occur VBD cord-009571-mygj2nd4 1654 18 in in IN cord-009571-mygj2nd4 1654 19 four four CD cord-009571-mygj2nd4 1654 20 electrophoretic electrophoretic JJ cord-009571-mygj2nd4 1654 21 forms form NNS cord-009571-mygj2nd4 1654 22 . . . cord-009571-mygj2nd4 1655 1 These these DT cord-009571-mygj2nd4 1655 2 were be VBD cord-009571-mygj2nd4 1655 3 purified purify VBN cord-009571-mygj2nd4 1655 4 2,000-fold 2,000-fold CD cord-009571-mygj2nd4 1655 5 and and CC cord-009571-mygj2nd4 1655 6 produced produce VBD cord-009571-mygj2nd4 1655 7 single single JJ cord-009571-mygj2nd4 1655 8 proteolytically proteolytically RB cord-009571-mygj2nd4 1655 9 active active JJ cord-009571-mygj2nd4 1655 10 bands band NNS cord-009571-mygj2nd4 1655 11 on on IN cord-009571-mygj2nd4 1655 12 disk disk NN cord-009571-mygj2nd4 1655 13 electrophoresis electrophoresis NN cord-009571-mygj2nd4 1655 14 . . . cord-009571-mygj2nd4 1656 1 These these DT cord-009571-mygj2nd4 1656 2 forms form NNS cord-009571-mygj2nd4 1656 3 were be VBD cord-009571-mygj2nd4 1656 4 separated separate VBN cord-009571-mygj2nd4 1656 5 by by IN cord-009571-mygj2nd4 1656 6 preparative preparative JJ cord-009571-mygj2nd4 1656 7 flat flat JJ cord-009571-mygj2nd4 1656 8 - - HYPH cord-009571-mygj2nd4 1656 9 bed bed NN cord-009571-mygj2nd4 1656 10 isoelectric isoelectric JJ cord-009571-mygj2nd4 1656 11 focusing focus VBG cord-009571-mygj2nd4 1656 12 and and CC cord-009571-mygj2nd4 1656 13 had have VBD cord-009571-mygj2nd4 1656 14 approximate approximate JJ cord-009571-mygj2nd4 1656 15 isoelectric isoelectric JJ cord-009571-mygj2nd4 1656 16 points point NNS cord-009571-mygj2nd4 1656 17 of of IN cord-009571-mygj2nd4 1656 18 8.7 8.7 CD cord-009571-mygj2nd4 1656 19 , , , cord-009571-mygj2nd4 1656 20 8.3 8.3 CD cord-009571-mygj2nd4 1656 21 , , , cord-009571-mygj2nd4 1656 22 7.6 7.6 CD cord-009571-mygj2nd4 1656 23 , , , cord-009571-mygj2nd4 1656 24 and and CC cord-009571-mygj2nd4 1656 25 7.1 7.1 CD cord-009571-mygj2nd4 1656 26 . . . cord-009571-mygj2nd4 1657 1 Gel gel NN cord-009571-mygj2nd4 1657 2 filtration filtration NN cord-009571-mygj2nd4 1657 3 and and CC cord-009571-mygj2nd4 1657 4 SDS SDS NNP cord-009571-mygj2nd4 1657 5 gel gel NN cord-009571-mygj2nd4 1657 6 electrophoresis electrophoresis NN cord-009571-mygj2nd4 1657 7 showed show VBD cord-009571-mygj2nd4 1657 8 that that IN cord-009571-mygj2nd4 1657 9 they -PRON- PRP cord-009571-mygj2nd4 1657 10 have have VBP cord-009571-mygj2nd4 1657 11 an an DT cord-009571-mygj2nd4 1657 12 apparent apparent JJ cord-009571-mygj2nd4 1657 13 molecular molecular JJ cord-009571-mygj2nd4 1657 14 weight weight NN cord-009571-mygj2nd4 1657 15 of of IN cord-009571-mygj2nd4 1657 16 25 25 CD cord-009571-mygj2nd4 1657 17 - - HYPH cord-009571-mygj2nd4 1657 18 27,OOO 27,ooo CD cord-009571-mygj2nd4 1657 19 and and CC cord-009571-mygj2nd4 1657 20 are be VBP cord-009571-mygj2nd4 1657 21 composed compose VBN cord-009571-mygj2nd4 1657 22 of of IN cord-009571-mygj2nd4 1657 23 subunits subunit NNS cord-009571-mygj2nd4 1657 24 of of IN cord-009571-mygj2nd4 1657 25 13 13 CD cord-009571-mygj2nd4 1657 26 - - SYM cord-009571-mygj2nd4 1657 27 14,000 14,000 CD cord-009571-mygj2nd4 1657 28 . . . cord-009571-mygj2nd4 1658 1 Gel gel NN cord-009571-mygj2nd4 1658 2 filtration filtration NN cord-009571-mygj2nd4 1658 3 and and CC cord-009571-mygj2nd4 1658 4 dialysis dialysis NN cord-009571-mygj2nd4 1658 5 indicated indicate VBD cord-009571-mygj2nd4 1658 6 their -PRON- PRP$ cord-009571-mygj2nd4 1658 7 tendency tendency NN cord-009571-mygj2nd4 1658 8 to to TO cord-009571-mygj2nd4 1658 9 disaggregate disaggregate VB cord-009571-mygj2nd4 1658 10 and and CC cord-009571-mygj2nd4 1658 11 reaggregate reaggregate VB cord-009571-mygj2nd4 1658 12 into into IN cord-009571-mygj2nd4 1658 13 monomers monomer NNS cord-009571-mygj2nd4 1658 14 and and CC cord-009571-mygj2nd4 1658 15 dimers dimer NNS cord-009571-mygj2nd4 1658 16 . . . cord-009571-mygj2nd4 1659 1 Their -PRON- PRP$ cord-009571-mygj2nd4 1659 2 proteoglycanase proteoglycanase NN cord-009571-mygj2nd4 1659 3 activity activity NN cord-009571-mygj2nd4 1659 4 passed pass VBD cord-009571-mygj2nd4 1659 5 through through IN cord-009571-mygj2nd4 1659 6 Visking visking NN cord-009571-mygj2nd4 1659 7 tubing tubing NN cord-009571-mygj2nd4 1659 8 and and CC cord-009571-mygj2nd4 1659 9 the the DT cord-009571-mygj2nd4 1659 10 passage passage NN cord-009571-mygj2nd4 1659 11 continued continue VBD cord-009571-mygj2nd4 1659 12 on on IN cord-009571-mygj2nd4 1659 13 repeated repeat VBN cord-009571-mygj2nd4 1659 14 dialysis dialysis NN cord-009571-mygj2nd4 1659 15 with with IN cord-009571-mygj2nd4 1659 16 fresh fresh JJ cord-009571-mygj2nd4 1659 17 buffer buffer NN cord-009571-mygj2nd4 1659 18 . . . cord-009571-mygj2nd4 1660 1 This this DT cord-009571-mygj2nd4 1660 2 was be VBD cord-009571-mygj2nd4 1660 3 prevented prevent VBN cord-009571-mygj2nd4 1660 4 to to IN cord-009571-mygj2nd4 1660 5 a a DT cord-009571-mygj2nd4 1660 6 large large JJ cord-009571-mygj2nd4 1660 7 extent extent NN cord-009571-mygj2nd4 1660 8 by by IN cord-009571-mygj2nd4 1660 9 dialysis dialysis NN cord-009571-mygj2nd4 1660 10 against against IN cord-009571-mygj2nd4 1660 11 zinc zinc NN cord-009571-mygj2nd4 1660 12 or or CC cord-009571-mygj2nd4 1660 13 cobalt cobalt NN cord-009571-mygj2nd4 1660 14 ions ion NNS cord-009571-mygj2nd4 1660 15 . . . cord-009571-mygj2nd4 1661 1 All all PDT cord-009571-mygj2nd4 1661 2 the the DT cord-009571-mygj2nd4 1661 3 forms form NNS cord-009571-mygj2nd4 1661 4 degraded degrade VBD cord-009571-mygj2nd4 1661 5 the the DT cord-009571-mygj2nd4 1661 6 protein protein NN cord-009571-mygj2nd4 1661 7 core core NN cord-009571-mygj2nd4 1661 8 of of IN cord-009571-mygj2nd4 1661 9 proteoglycan proteoglycan JJ cord-009571-mygj2nd4 1661 10 subunit subunit NN cord-009571-mygj2nd4 1661 11 optimally optimally RB cord-009571-mygj2nd4 1661 12 at at IN cord-009571-mygj2nd4 1661 13 pH pH NNP cord-009571-mygj2nd4 1661 14 7.25 7.25 CD cord-009571-mygj2nd4 1661 15 and and CC cord-009571-mygj2nd4 1661 16 were be VBD cord-009571-mygj2nd4 1661 17 inhibited inhibit VBN cord-009571-mygj2nd4 1661 18 almost almost RB cord-009571-mygj2nd4 1661 19 completely completely RB cord-009571-mygj2nd4 1661 20 by by IN cord-009571-mygj2nd4 1661 21 addition addition NN cord-009571-mygj2nd4 1661 22 of of IN cord-009571-mygj2nd4 1661 23 o o NN cord-009571-mygj2nd4 1661 24 - - HYPH cord-009571-mygj2nd4 1661 25 phenanthroline phenanthroline NN cord-009571-mygj2nd4 1661 26 or or CC cord-009571-mygj2nd4 1661 27 passage passage VB cord-009571-mygj2nd4 1661 28 through through IN cord-009571-mygj2nd4 1661 29 the the DT cord-009571-mygj2nd4 1661 30 chelating chelating NN cord-009571-mygj2nd4 1661 31 resin resin NN cord-009571-mygj2nd4 1661 32 , , , cord-009571-mygj2nd4 1661 33 Chelex Chelex NNP cord-009571-mygj2nd4 1661 34 . . . cord-009571-mygj2nd4 1662 1 However however RB cord-009571-mygj2nd4 1662 2 , , , cord-009571-mygj2nd4 1662 3 they -PRON- PRP cord-009571-mygj2nd4 1662 4 differed differ VBD cord-009571-mygj2nd4 1662 5 in in IN cord-009571-mygj2nd4 1662 6 their -PRON- PRP$ cord-009571-mygj2nd4 1662 7 inhibition inhibition NN cord-009571-mygj2nd4 1662 8 by by IN cord-009571-mygj2nd4 1662 9 EDTA EDTA NNP cord-009571-mygj2nd4 1662 10 , , , cord-009571-mygj2nd4 1662 11 the the DT cord-009571-mygj2nd4 1662 12 most most RBS cord-009571-mygj2nd4 1662 13 cationic cationic JJ cord-009571-mygj2nd4 1662 14 forms form NNS cord-009571-mygj2nd4 1662 15 being be VBG cord-009571-mygj2nd4 1662 16 the the DT cord-009571-mygj2nd4 1662 17 least least RBS cord-009571-mygj2nd4 1662 18 inhibited inhibited JJ cord-009571-mygj2nd4 1662 19 . . . cord-009571-mygj2nd4 1663 1 Also also RB cord-009571-mygj2nd4 1663 2 , , , cord-009571-mygj2nd4 1663 3 the the DT cord-009571-mygj2nd4 1663 4 3 3 CD cord-009571-mygj2nd4 1663 5 most most RBS cord-009571-mygj2nd4 1663 6 cationic cationic JJ cord-009571-mygj2nd4 1663 7 forms form NNS cord-009571-mygj2nd4 1663 8 had have VBD cord-009571-mygj2nd4 1663 9 n n NN cord-009571-mygj2nd4 1663 10 o o NN cord-009571-mygj2nd4 1663 11 activity activity NN cord-009571-mygj2nd4 1663 12 on on IN cord-009571-mygj2nd4 1663 13 casein casein NN cord-009571-mygj2nd4 1663 14 , , , cord-009571-mygj2nd4 1663 15 histone histone NN cord-009571-mygj2nd4 1663 16 , , , cord-009571-mygj2nd4 1663 17 and and CC cord-009571-mygj2nd4 1663 18 the the DT cord-009571-mygj2nd4 1663 19 link link NN cord-009571-mygj2nd4 1663 20 proteins protein NNS cord-009571-mygj2nd4 1663 21 , , , cord-009571-mygj2nd4 1663 22 indicating indicate VBG cord-009571-mygj2nd4 1663 23 a a DT cord-009571-mygj2nd4 1663 24 relative relative JJ cord-009571-mygj2nd4 1663 25 specificity specificity NN cord-009571-mygj2nd4 1663 26 for for IN cord-009571-mygj2nd4 1663 27 degrading degrade VBG cord-009571-mygj2nd4 1663 28 proteoglycan proteoglycan NN cord-009571-mygj2nd4 1663 29 . . . cord-009571-mygj2nd4 1664 1 These these DT cord-009571-mygj2nd4 1664 2 enzyme enzyme NN cord-009571-mygj2nd4 1664 3 forms form NNS cord-009571-mygj2nd4 1664 4 which which WDT cord-009571-mygj2nd4 1664 5 are be VBP cord-009571-mygj2nd4 1664 6 active active JJ cord-009571-mygj2nd4 1664 7 at at IN cord-009571-mygj2nd4 1664 8 the the DT cord-009571-mygj2nd4 1664 9 pH pH NNP cord-009571-mygj2nd4 1664 10 in in IN cord-009571-mygj2nd4 1664 11 cartilage cartilage NN cord-009571-mygj2nd4 1664 12 matrix matrix NN cord-009571-mygj2nd4 1664 13 may may MD cord-009571-mygj2nd4 1664 14 have have VB cord-009571-mygj2nd4 1664 15 an an DT cord-009571-mygj2nd4 1664 16 important important JJ cord-009571-mygj2nd4 1664 17 role role NN cord-009571-mygj2nd4 1664 18 in in IN cord-009571-mygj2nd4 1664 19 proteoglycan proteoglycan JJ cord-009571-mygj2nd4 1664 20 degradation degradation NN cord-009571-mygj2nd4 1664 21 in in IN cord-009571-mygj2nd4 1664 22 osteoarthritis osteoarthritis NN cord-009571-mygj2nd4 1664 23 . . . cord-009571-mygj2nd4 1664 24 _SP cord-009571-mygj2nd4 1665 1 BXSB BXSB NNP cord-009571-mygj2nd4 1665 2 mice mouse NNS cord-009571-mygj2nd4 1665 3 ( ( -LRB- cord-009571-mygj2nd4 1665 4 developed develop VBN cord-009571-mygj2nd4 1665 5 by by IN cord-009571-mygj2nd4 1665 6 Dr. Dr. NNP cord-009571-mygj2nd4 1665 7 E. E. NNP cord-009571-mygj2nd4 1665 8 D. D. NNP cord-009571-mygj2nd4 1665 9 Murphy Murphy NNP cord-009571-mygj2nd4 1665 10 , , , cord-009571-mygj2nd4 1665 11 Jackson Jackson NNP cord-009571-mygj2nd4 1665 12 Laboratory Laboratory NNP cord-009571-mygj2nd4 1665 13 ) ) -RRB- cord-009571-mygj2nd4 1665 14 spontaneously spontaneously RB cord-009571-mygj2nd4 1665 15 evolve evolve VB cord-009571-mygj2nd4 1665 16 a a DT cord-009571-mygj2nd4 1665 17 lupus lupus NN cord-009571-mygj2nd4 1665 18 - - HYPH cord-009571-mygj2nd4 1665 19 like like JJ cord-009571-mygj2nd4 1665 20 disorder disorder NN cord-009571-mygj2nd4 1665 21 similar similar JJ cord-009571-mygj2nd4 1665 22 to to IN cord-009571-mygj2nd4 1665 23 the the DT cord-009571-mygj2nd4 1665 24 disease disease NN cord-009571-mygj2nd4 1665 25 of of IN cord-009571-mygj2nd4 1665 26 NZB NZB NNP cord-009571-mygj2nd4 1665 27 / / SYM cord-009571-mygj2nd4 1665 28 NZW NZW NNP cord-009571-mygj2nd4 1665 29 ( ( -LRB- cord-009571-mygj2nd4 1665 30 B B NNP cord-009571-mygj2nd4 1665 31 / / SYM cord-009571-mygj2nd4 1665 32 W W NNP cord-009571-mygj2nd4 1665 33 ) ) -RRB- cord-009571-mygj2nd4 1665 34 mice mouse NNS cord-009571-mygj2nd4 1665 35 . . . cord-009571-mygj2nd4 1666 1 However however RB cord-009571-mygj2nd4 1666 2 , , , cord-009571-mygj2nd4 1666 3 in in IN cord-009571-mygj2nd4 1666 4 contrast contrast NN cord-009571-mygj2nd4 1666 5 to to IN cord-009571-mygj2nd4 1666 6 B B NNP cord-009571-mygj2nd4 1666 7 / / SYM cord-009571-mygj2nd4 1666 8 W w NN cord-009571-mygj2nd4 1666 9 mice mouse NNS cord-009571-mygj2nd4 1666 10 , , , cord-009571-mygj2nd4 1666 11 the the DT cord-009571-mygj2nd4 1666 12 BXSB BXSB NNP cord-009571-mygj2nd4 1666 13 disease disease NN cord-009571-mygj2nd4 1666 14 is be VBZ cord-009571-mygj2nd4 1666 15 more more RBR cord-009571-mygj2nd4 1666 16 severe severe JJ cord-009571-mygj2nd4 1666 17 in in IN cord-009571-mygj2nd4 1666 18 males male NNS cord-009571-mygj2nd4 1666 19 who who WP cord-009571-mygj2nd4 1666 20 die die VBP cord-009571-mygj2nd4 1666 21 of of IN cord-009571-mygj2nd4 1666 22 immune immune JJ cord-009571-mygj2nd4 1666 23 complex complex JJ cord-009571-mygj2nd4 1666 24 nephritis nephritis NN cord-009571-mygj2nd4 1666 25 at at IN cord-009571-mygj2nd4 1666 26 a a DT cord-009571-mygj2nd4 1666 27 mean mean JJ cord-009571-mygj2nd4 1666 28 age age NN cord-009571-mygj2nd4 1666 29 of of IN cord-009571-mygj2nd4 1666 30 5 5 CD cord-009571-mygj2nd4 1666 31 months month NNS cord-009571-mygj2nd4 1666 32 . . . cord-009571-mygj2nd4 1667 1 We -PRON- PRP cord-009571-mygj2nd4 1667 2 have have VBP cord-009571-mygj2nd4 1667 3 compared compare VBN cord-009571-mygj2nd4 1667 4 the the DT cord-009571-mygj2nd4 1667 5 formation formation NN cord-009571-mygj2nd4 1667 6 of of IN cord-009571-mygj2nd4 1667 7 antibodies antibody NNS cord-009571-mygj2nd4 1667 8 to to TO cord-009571-mygj2nd4 1667 9 DNA dna VB cord-009571-mygj2nd4 1667 10 in in IN cord-009571-mygj2nd4 1667 11 BXSB BXSB NNP cord-009571-mygj2nd4 1667 12 and and CC cord-009571-mygj2nd4 1667 13 B B NNP cord-009571-mygj2nd4 1667 14 / / SYM cord-009571-mygj2nd4 1667 15 W w NN cord-009571-mygj2nd4 1667 16 mice mouse NNS cord-009571-mygj2nd4 1667 17 . . . cord-009571-mygj2nd4 1668 1 The the DT cord-009571-mygj2nd4 1668 2 early early JJ cord-009571-mygj2nd4 1668 3 appearance appearance NN cord-009571-mygj2nd4 1668 4 of of IN cord-009571-mygj2nd4 1668 5 autoimmunity autoimmunity NN cord-009571-mygj2nd4 1668 6 in in IN cord-009571-mygj2nd4 1668 7 male male JJ cord-009571-mygj2nd4 1668 8 BXSB BXSB NNP cord-009571-mygj2nd4 1668 9 mice mice NN cord-009571-mygj2nd4 1668 10 is be VBZ cord-009571-mygj2nd4 1668 11 associated associate VBN cord-009571-mygj2nd4 1668 12 with with IN cord-009571-mygj2nd4 1668 13 a a DT cord-009571-mygj2nd4 1668 14 premature premature JJ cord-009571-mygj2nd4 1668 15 switch switch NN cord-009571-mygj2nd4 1668 16 from from IN cord-009571-mygj2nd4 1668 17 IgM IgM NNP cord-009571-mygj2nd4 1668 18 to to IN cord-009571-mygj2nd4 1668 19 IgG IgG NNP cord-009571-mygj2nd4 1668 20 serum serum NN cord-009571-mygj2nd4 1668 21 antibodies antibody NNS cord-009571-mygj2nd4 1668 22 to to IN cord-009571-mygj2nd4 1668 23 DNA DNA NNP cord-009571-mygj2nd4 1668 24 . . . cord-009571-mygj2nd4 1669 1 This this DT cord-009571-mygj2nd4 1669 2 is be VBZ cord-009571-mygj2nd4 1669 3 analogous analogous JJ cord-009571-mygj2nd4 1669 4 t t NN cord-009571-mygj2nd4 1669 5 o o NN cord-009571-mygj2nd4 1670 1 the the DT cord-009571-mygj2nd4 1670 2 early early JJ cord-009571-mygj2nd4 1670 3 switch switch NN cord-009571-mygj2nd4 1670 4 from from IN cord-009571-mygj2nd4 1670 5 IgM IgM NNP cord-009571-mygj2nd4 1670 6 to to IN cord-009571-mygj2nd4 1670 7 IgG IgG NNP cord-009571-mygj2nd4 1670 8 antibodies antibody NNS cord-009571-mygj2nd4 1670 9 in in IN cord-009571-mygj2nd4 1670 10 female female JJ cord-009571-mygj2nd4 1670 11 B B NNP cord-009571-mygj2nd4 1670 12 / / SYM cord-009571-mygj2nd4 1670 13 W w NN cord-009571-mygj2nd4 1670 14 mice mouse NNS cord-009571-mygj2nd4 1670 15 which which WDT cord-009571-mygj2nd4 1670 16 is be VBZ cord-009571-mygj2nd4 1670 17 associated associate VBN cord-009571-mygj2nd4 1670 18 with with IN cord-009571-mygj2nd4 1670 19 accelerated accelerated JJ cord-009571-mygj2nd4 1670 20 disease disease NN cord-009571-mygj2nd4 1670 21 and and CC cord-009571-mygj2nd4 1670 22 impending impending JJ cord-009571-mygj2nd4 1670 23 death death NN cord-009571-mygj2nd4 1670 24 . . . cord-009571-mygj2nd4 1671 1 We -PRON- PRP cord-009571-mygj2nd4 1671 2 have have VBP cord-009571-mygj2nd4 1671 3 also also RB cord-009571-mygj2nd4 1671 4 measured measure VBN cord-009571-mygj2nd4 1671 5 the the DT cord-009571-mygj2nd4 1671 6 spontaneous spontaneous JJ cord-009571-mygj2nd4 1671 7 synthesis synthesis NN cord-009571-mygj2nd4 1671 8 of of IN cord-009571-mygj2nd4 1671 9 antibodies antibody NNS cord-009571-mygj2nd4 1671 10 to to IN cord-009571-mygj2nd4 1671 11 DNA DNA NNP cord-009571-mygj2nd4 1671 12 by by IN cord-009571-mygj2nd4 1671 13 spleen spleen NN cord-009571-mygj2nd4 1671 14 cells cell NNS cord-009571-mygj2nd4 1671 15 cultured cultured JJ cord-009571-mygj2nd4 1671 16 for for IN cord-009571-mygj2nd4 1671 17 96 96 CD cord-009571-mygj2nd4 1671 18 hours hour NNS cord-009571-mygj2nd4 1671 19 . . . cord-009571-mygj2nd4 1672 1 Culture culture NN cord-009571-mygj2nd4 1672 2 supernatants supernatant NNS cord-009571-mygj2nd4 1672 3 contain contain VBP cord-009571-mygj2nd4 1672 4 immunoglobulin immunoglobulin NN cord-009571-mygj2nd4 1672 5 which which WDT cord-009571-mygj2nd4 1672 6 binds bind VBZ cord-009571-mygj2nd4 1672 7 DNA dna NN cord-009571-mygj2nd4 1672 8 specifically specifically RB cord-009571-mygj2nd4 1672 9 as as IN cord-009571-mygj2nd4 1672 10 determined determine VBN cord-009571-mygj2nd4 1672 11 by by IN cord-009571-mygj2nd4 1672 12 radioimmunoprecipitation radioimmunoprecipitation NN cord-009571-mygj2nd4 1672 13 . . . cord-009571-mygj2nd4 1673 1 Two two CD cord-009571-mygj2nd4 1673 2 month month NN cord-009571-mygj2nd4 1673 3 old old JJ cord-009571-mygj2nd4 1673 4 male male NN cord-009571-mygj2nd4 1673 5 BXSB BXSB NNP cord-009571-mygj2nd4 1673 6 mice mouse NNS cord-009571-mygj2nd4 1673 7 produce produce VBP cord-009571-mygj2nd4 1673 8 more more JJR cord-009571-mygj2nd4 1673 9 antibody antibody NN cord-009571-mygj2nd4 1673 10 to to IN cord-009571-mygj2nd4 1673 11 D D NNP cord-009571-mygj2nd4 1673 12 N N NNP cord-009571-mygj2nd4 1673 13 A a NN cord-009571-mygj2nd4 1673 14 in in IN cord-009571-mygj2nd4 1673 15 culture culture NN cord-009571-mygj2nd4 1673 16 than than IN cord-009571-mygj2nd4 1673 17 d d NN cord-009571-mygj2nd4 1673 18 o o CD cord-009571-mygj2nd4 1673 19 age age NN cord-009571-mygj2nd4 1673 20 - - HYPH cord-009571-mygj2nd4 1673 21 matched match VBN cord-009571-mygj2nd4 1673 22 female female JJ cord-009571-mygj2nd4 1673 23 mice mouse NNS cord-009571-mygj2nd4 1673 24 of of IN cord-009571-mygj2nd4 1673 25 BXSB BXSB NNP cord-009571-mygj2nd4 1673 26 , , , cord-009571-mygj2nd4 1673 27 B B NNP cord-009571-mygj2nd4 1673 28 / / SYM cord-009571-mygj2nd4 1673 29 W W NNP cord-009571-mygj2nd4 1673 30 , , , cord-009571-mygj2nd4 1673 31 Balb Balb NNP cord-009571-mygj2nd4 1673 32 / / SYM cord-009571-mygj2nd4 1673 33 c c NNP cord-009571-mygj2nd4 1673 34 , , , cord-009571-mygj2nd4 1673 35 or or CC cord-009571-mygj2nd4 1673 36 C57 C57 NNP cord-009571-mygj2nd4 1673 37 B1/6 B1/6 NNP cord-009571-mygj2nd4 1673 38 strains strain NNS cord-009571-mygj2nd4 1673 39 . . . cord-009571-mygj2nd4 1674 1 Anti anti JJ cord-009571-mygj2nd4 1674 2 - - JJ cord-009571-mygj2nd4 1674 3 DNA dna JJ cord-009571-mygj2nd4 1674 4 production production NN cord-009571-mygj2nd4 1674 5 in in IN cord-009571-mygj2nd4 1674 6 culture culture NN cord-009571-mygj2nd4 1674 7 increases increase VBZ cord-009571-mygj2nd4 1674 8 with with IN cord-009571-mygj2nd4 1674 9 age age NN cord-009571-mygj2nd4 1674 10 in in IN cord-009571-mygj2nd4 1674 11 B B NNP cord-009571-mygj2nd4 1674 12 / / SYM cord-009571-mygj2nd4 1674 13 W w NN cord-009571-mygj2nd4 1674 14 mice mouse NNS cord-009571-mygj2nd4 1674 15 . . . cord-009571-mygj2nd4 1675 1 Older old JJR cord-009571-mygj2nd4 1675 2 female female JJ cord-009571-mygj2nd4 1675 3 B B NNP cord-009571-mygj2nd4 1675 4 / / SYM cord-009571-mygj2nd4 1675 5 W w NN cord-009571-mygj2nd4 1675 6 mice mouse NNS cord-009571-mygj2nd4 1675 7 subjected subject VBN cord-009571-mygj2nd4 1675 8 to to IN cord-009571-mygj2nd4 1675 9 prepubertal prepubertal JJ cord-009571-mygj2nd4 1675 10 castration castration NN cord-009571-mygj2nd4 1675 11 and and CC cord-009571-mygj2nd4 1675 12 treated treat VBN cord-009571-mygj2nd4 1675 13 with with IN cord-009571-mygj2nd4 1675 14 androgen androgen NN cord-009571-mygj2nd4 1675 15 produce produce NN cord-009571-mygj2nd4 1675 16 significantly significantly RB cord-009571-mygj2nd4 1675 17 less less RBR cord-009571-mygj2nd4 1675 18 anti anti JJ cord-009571-mygj2nd4 1675 19 - - JJ cord-009571-mygj2nd4 1675 20 DNA dna NN cord-009571-mygj2nd4 1675 21 in in IN cord-009571-mygj2nd4 1675 22 culture culture NN cord-009571-mygj2nd4 1675 23 as as IN cord-009571-mygj2nd4 1675 24 compared compare VBN cord-009571-mygj2nd4 1675 25 to to IN cord-009571-mygj2nd4 1675 26 sham sham NN cord-009571-mygj2nd4 1675 27 or or CC cord-009571-mygj2nd4 1675 28 estrogen estrogen NN cord-009571-mygj2nd4 1675 29 - - HYPH cord-009571-mygj2nd4 1675 30 treated treat VBN cord-009571-mygj2nd4 1675 31 controls control NNS cord-009571-mygj2nd4 1675 32 ( ( -LRB- cord-009571-mygj2nd4 1675 33 P p NN cord-009571-mygj2nd4 1675 34 < < XX cord-009571-mygj2nd4 1675 35 0.017 0.017 XX cord-009571-mygj2nd4 1675 36 ) ) -RRB- cord-009571-mygj2nd4 1675 37 . . . cord-009571-mygj2nd4 1676 1 The the DT cord-009571-mygj2nd4 1676 2 effect effect NN cord-009571-mygj2nd4 1676 3 of of IN cord-009571-mygj2nd4 1676 4 hormone hormone NN cord-009571-mygj2nd4 1676 5 treatment treatment NN cord-009571-mygj2nd4 1676 6 on on IN cord-009571-mygj2nd4 1676 7 BXSB BXSB NNP cord-009571-mygj2nd4 1676 8 mice mouse NNS cord-009571-mygj2nd4 1676 9 is be VBZ cord-009571-mygj2nd4 1676 10 currently currently RB cord-009571-mygj2nd4 1676 11 under under IN cord-009571-mygj2nd4 1676 12 investigation investigation NN cord-009571-mygj2nd4 1676 13 . . . cord-009571-mygj2nd4 1677 1 These these DT cord-009571-mygj2nd4 1677 2 results result NNS cord-009571-mygj2nd4 1677 3 suggest suggest VBP cord-009571-mygj2nd4 1677 4 that that IN cord-009571-mygj2nd4 1677 5 the the DT cord-009571-mygj2nd4 1677 6 male male NN cord-009571-mygj2nd4 1677 7 - - HYPH cord-009571-mygj2nd4 1677 8 dominant dominant JJ cord-009571-mygj2nd4 1677 9 disease disease NN cord-009571-mygj2nd4 1677 10 of of IN cord-009571-mygj2nd4 1677 11 BXSB BXSB NNP cord-009571-mygj2nd4 1677 12 mice mouse NNS cord-009571-mygj2nd4 1677 13 is be VBZ cord-009571-mygj2nd4 1677 14 reflected reflect VBN cord-009571-mygj2nd4 1677 15 in in IN cord-009571-mygj2nd4 1677 16 early early JJ cord-009571-mygj2nd4 1677 17 synthesis synthesis NN cord-009571-mygj2nd4 1677 18 of of IN cord-009571-mygj2nd4 1677 19 antibodies antibody NNS cord-009571-mygj2nd4 1678 1 t t NNP cord-009571-mygj2nd4 1678 2 o o NN cord-009571-mygj2nd4 1678 3 D d NN cord-009571-mygj2nd4 1679 1 N n CC cord-009571-mygj2nd4 1679 2 A a NN cord-009571-mygj2nd4 1680 1 which which WDT cord-009571-mygj2nd4 1680 2 is be VBZ cord-009571-mygj2nd4 1680 3 apparent apparent JJ cord-009571-mygj2nd4 1680 4 both both CC cord-009571-mygj2nd4 1680 5 in in IN cord-009571-mygj2nd4 1680 6 vivo vivo NN cord-009571-mygj2nd4 1680 7 and and CC cord-009571-mygj2nd4 1680 8 in in IN cord-009571-mygj2nd4 1680 9 vitro vitro FW cord-009571-mygj2nd4 1680 10 . . . cord-009571-mygj2nd4 1681 1 Female female JJ cord-009571-mygj2nd4 1681 2 43 43 CD cord-009571-mygj2nd4 1682 1 The the DT cord-009571-mygj2nd4 1682 2 Rheumatoid Rheumatoid NNP cord-009571-mygj2nd4 1682 3 Nodule Nodule NNP cord-009571-mygj2nd4 1682 4 : : : cord-009571-mygj2nd4 1683 1 Clinical clinical JJ cord-009571-mygj2nd4 1683 2 Significance significance NN cord-009571-mygj2nd4 1684 1 Although although IN cord-009571-mygj2nd4 1684 2 the the DT cord-009571-mygj2nd4 1684 3 subcutaneous subcutaneous JJ cord-009571-mygj2nd4 1684 4 nodule nodule NN cord-009571-mygj2nd4 1684 5 ( ( -LRB- cord-009571-mygj2nd4 1684 6 SCN SCN NNP cord-009571-mygj2nd4 1684 7 ) ) -RRB- cord-009571-mygj2nd4 1684 8 is be VBZ cord-009571-mygj2nd4 1684 9 the the DT cord-009571-mygj2nd4 1684 10 extraarticular extraarticular JJ cord-009571-mygj2nd4 1684 11 hallmark hallmark NN cord-009571-mygj2nd4 1684 12 of of IN cord-009571-mygj2nd4 1684 13 rheumatoid rheumatoid NNP cord-009571-mygj2nd4 1684 14 arthritis arthritis NN cord-009571-mygj2nd4 1684 15 ( ( -LRB- cord-009571-mygj2nd4 1684 16 RA RA NNP cord-009571-mygj2nd4 1684 17 ) ) -RRB- cord-009571-mygj2nd4 1684 18 , , , cord-009571-mygj2nd4 1684 19 its -PRON- PRP$ cord-009571-mygj2nd4 1684 20 clinical clinical JJ cord-009571-mygj2nd4 1684 21 significance significance NN cord-009571-mygj2nd4 1684 22 has have VBZ cord-009571-mygj2nd4 1684 23 not not RB cord-009571-mygj2nd4 1684 24 been be VBN cord-009571-mygj2nd4 1684 25 established establish VBN cord-009571-mygj2nd4 1684 26 . . . cord-009571-mygj2nd4 1685 1 It -PRON- PRP cord-009571-mygj2nd4 1685 2 was be VBD cord-009571-mygj2nd4 1685 3 our -PRON- PRP$ cord-009571-mygj2nd4 1685 4 thesis thesis NN cord-009571-mygj2nd4 1685 5 that that IN cord-009571-mygj2nd4 1685 6 the the DT cord-009571-mygj2nd4 1685 7 presence presence NN cord-009571-mygj2nd4 1685 8 of of IN cord-009571-mygj2nd4 1685 9 SCN SCN NNP cord-009571-mygj2nd4 1685 10 would would MD cord-009571-mygj2nd4 1685 11 serve serve VB cord-009571-mygj2nd4 1685 12 to to TO cord-009571-mygj2nd4 1685 13 identify identify VB cord-009571-mygj2nd4 1685 14 the the DT cord-009571-mygj2nd4 1685 15 subset(s subset(s NN cord-009571-mygj2nd4 1685 16 ) ) -RRB- cord-009571-mygj2nd4 1685 17 of of IN cord-009571-mygj2nd4 1685 18 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 1685 19 patients patient NNS cord-009571-mygj2nd4 1685 20 with with IN cord-009571-mygj2nd4 1685 21 systemic systemic JJ cord-009571-mygj2nd4 1685 22 and and CC cord-009571-mygj2nd4 1685 23 highly highly RB cord-009571-mygj2nd4 1685 24 immunoreactive immunoreactive JJ cord-009571-mygj2nd4 1685 25 disease disease NN cord-009571-mygj2nd4 1685 26 . . . cord-009571-mygj2nd4 1686 1 All all DT cord-009571-mygj2nd4 1686 2 patients patient NNS cord-009571-mygj2nd4 1686 3 with with IN cord-009571-mygj2nd4 1686 4 definite definite JJ cord-009571-mygj2nd4 1686 5 ( ( -LRB- cord-009571-mygj2nd4 1686 6 46 46 CD cord-009571-mygj2nd4 1686 7 ) ) -RRB- cord-009571-mygj2nd4 1686 8 and and CC cord-009571-mygj2nd4 1686 9 classic classic JJ cord-009571-mygj2nd4 1686 10 ( ( -LRB- cord-009571-mygj2nd4 1686 11 165 165 CD cord-009571-mygj2nd4 1686 12 ) ) -RRB- cord-009571-mygj2nd4 1686 13 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 1686 14 arthritis arthritis NN cord-009571-mygj2nd4 1686 15 who who WP cord-009571-mygj2nd4 1686 16 had have VBD cord-009571-mygj2nd4 1686 17 an an DT cord-009571-mygj2nd4 1686 18 initial initial JJ cord-009571-mygj2nd4 1686 19 unit unit NN cord-009571-mygj2nd4 1686 20 admission admission NN cord-009571-mygj2nd4 1686 21 during during IN cord-009571-mygj2nd4 1686 22 the the DT cord-009571-mygj2nd4 1686 23 interval interval NN cord-009571-mygj2nd4 1686 24 January January NNP cord-009571-mygj2nd4 1686 25 1974 1974 CD cord-009571-mygj2nd4 1686 26 through through IN cord-009571-mygj2nd4 1686 27 June June NNP cord-009571-mygj2nd4 1686 28 1976 1976 CD cord-009571-mygj2nd4 1686 29 were be VBD cord-009571-mygj2nd4 1686 30 selected select VBN cord-009571-mygj2nd4 1686 31 for for IN cord-009571-mygj2nd4 1686 32 study study NN cord-009571-mygj2nd4 1686 33 . . . cord-009571-mygj2nd4 1687 1 Primary primary JJ cord-009571-mygj2nd4 1687 2 reasons reason NNS cord-009571-mygj2nd4 1687 3 for for IN cord-009571-mygj2nd4 1687 4 admission admission NN cord-009571-mygj2nd4 1687 5 included include VBD cord-009571-mygj2nd4 1687 6 active active JJ cord-009571-mygj2nd4 1687 7 synovitis synovitis NNP cord-009571-mygj2nd4 1687 8 ( ( -LRB- cord-009571-mygj2nd4 1687 9 57 57 CD cord-009571-mygj2nd4 1687 10 % % NN cord-009571-mygj2nd4 1687 11 ) ) -RRB- cord-009571-mygj2nd4 1687 12 , , , cord-009571-mygj2nd4 1687 13 orthopedic orthopedic NN cord-009571-mygj2nd4 1687 14 surgery surgery NN cord-009571-mygj2nd4 1687 15 ( ( -LRB- cord-009571-mygj2nd4 1687 16 17 17 CD cord-009571-mygj2nd4 1687 17 % % NN cord-009571-mygj2nd4 1687 18 ) ) -RRB- cord-009571-mygj2nd4 1687 19 , , , cord-009571-mygj2nd4 1687 20 and and CC cord-009571-mygj2nd4 1687 21 a a DT cord-009571-mygj2nd4 1687 22 miscellany miscellany NN cord-009571-mygj2nd4 1687 23 ( ( -LRB- cord-009571-mygj2nd4 1687 24 26 26 CD cord-009571-mygj2nd4 1687 25 % % NN cord-009571-mygj2nd4 1687 26 ) ) -RRB- cord-009571-mygj2nd4 1687 27 of of IN cord-009571-mygj2nd4 1687 28 therapeutic therapeutic JJ cord-009571-mygj2nd4 1687 29 complications complication NNS cord-009571-mygj2nd4 1687 30 and and CC cord-009571-mygj2nd4 1687 31 intercurrent intercurrent NN cord-009571-mygj2nd4 1687 32 illness illness NN cord-009571-mygj2nd4 1687 33 . . . cord-009571-mygj2nd4 1688 1 Of of IN cord-009571-mygj2nd4 1688 2 the the DT cord-009571-mygj2nd4 1688 3 21 21 CD cord-009571-mygj2nd4 1688 4 1 1 CD cord-009571-mygj2nd4 1688 5 patients patient NNS cord-009571-mygj2nd4 1688 6 , , , cord-009571-mygj2nd4 1688 7 91 91 CD cord-009571-mygj2nd4 1688 8 ( ( -LRB- cord-009571-mygj2nd4 1688 9 43 43 CD cord-009571-mygj2nd4 1688 10 % % NN cord-009571-mygj2nd4 1688 11 ) ) -RRB- cord-009571-mygj2nd4 1688 12 had have VBD cord-009571-mygj2nd4 1688 13 SCN SCN NNP cord-009571-mygj2nd4 1688 14 on on IN cord-009571-mygj2nd4 1688 15 admission admission NN cord-009571-mygj2nd4 1688 16 or or CC cord-009571-mygj2nd4 1688 17 by by IN cord-009571-mygj2nd4 1688 18 documented document VBN cord-009571-mygj2nd4 1688 19 history history NN cord-009571-mygj2nd4 1688 20 . . . cord-009571-mygj2nd4 1689 1 Medical medical JJ cord-009571-mygj2nd4 1689 2 record record NN cord-009571-mygj2nd4 1689 3 analysis analysis NN cord-009571-mygj2nd4 1689 4 per per IN cord-009571-mygj2nd4 1689 5 protocol protocol NN cord-009571-mygj2nd4 1689 6 revealed reveal VBD cord-009571-mygj2nd4 1689 7 patients patient NNS cord-009571-mygj2nd4 1689 8 with with IN cord-009571-mygj2nd4 1689 9 and and CC cord-009571-mygj2nd4 1689 10 without without IN cord-009571-mygj2nd4 1689 11 SCN SCN NNP cord-009571-mygj2nd4 1689 12 were be VBD cord-009571-mygj2nd4 1689 13 comparable comparable JJ cord-009571-mygj2nd4 1689 14 in in IN cord-009571-mygj2nd4 1689 15 terms term NNS cord-009571-mygj2nd4 1689 16 of of IN cord-009571-mygj2nd4 1689 17 demography demography NN cord-009571-mygj2nd4 1689 18 , , , cord-009571-mygj2nd4 1689 19 duration duration NN cord-009571-mygj2nd4 1689 20 , , , cord-009571-mygj2nd4 1689 21 and and CC cord-009571-mygj2nd4 1689 22 activity activity NN cord-009571-mygj2nd4 1689 23 of of IN cord-009571-mygj2nd4 1689 24 RA RA NNP cord-009571-mygj2nd4 1689 25 . . . cord-009571-mygj2nd4 1690 1 Similarly similarly RB cord-009571-mygj2nd4 1690 2 , , , cord-009571-mygj2nd4 1690 3 systemic systemic JJ cord-009571-mygj2nd4 1690 4 features feature NNS cord-009571-mygj2nd4 1690 5 did do VBD cord-009571-mygj2nd4 1690 6 not not RB cord-009571-mygj2nd4 1690 7 differ differ VB cord-009571-mygj2nd4 1690 8 significantly significantly RB cord-009571-mygj2nd4 1690 9 between between IN cord-009571-mygj2nd4 1690 10 two two CD cord-009571-mygj2nd4 1690 11 groups group NNS cord-009571-mygj2nd4 1690 12 , , , cord-009571-mygj2nd4 1690 13 as as IN cord-009571-mygj2nd4 1690 14 shown show VBN cord-009571-mygj2nd4 1690 15 in in IN cord-009571-mygj2nd4 1690 16 the the DT cord-009571-mygj2nd4 1690 17 table table NN cord-009571-mygj2nd4 1690 18 . . . cord-009571-mygj2nd4 1691 1 With with IN cord-009571-mygj2nd4 1691 2 regard regard NN cord-009571-mygj2nd4 1691 3 to to IN cord-009571-mygj2nd4 1691 4 sero sero NN cord-009571-mygj2nd4 1691 5 - - HYPH cord-009571-mygj2nd4 1691 6 reactivity reactivity NN cord-009571-mygj2nd4 1691 7 , , , cord-009571-mygj2nd4 1691 8 patients patient NNS cord-009571-mygj2nd4 1691 9 with with IN cord-009571-mygj2nd4 1691 10 SCN SCN NNP cord-009571-mygj2nd4 1691 11 and and CC cord-009571-mygj2nd4 1691 12 the the DT cord-009571-mygj2nd4 1691 13 anodular anodular JJ cord-009571-mygj2nd4 1691 14 group group NN cord-009571-mygj2nd4 1691 15 were be VBD cord-009571-mygj2nd4 1691 16 also also RB cord-009571-mygj2nd4 1691 17 alike alike RB cord-009571-mygj2nd4 1691 18 in in IN cord-009571-mygj2nd4 1691 19 terms term NNS cord-009571-mygj2nd4 1691 20 of of IN cord-009571-mygj2nd4 1691 21 the the DT cord-009571-mygj2nd4 1691 22 presence presence NN cord-009571-mygj2nd4 1691 23 of of IN cord-009571-mygj2nd4 1691 24 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1691 25 factors factor NNS cord-009571-mygj2nd4 1691 26 ( ( -LRB- cord-009571-mygj2nd4 1691 27 97 97 CD cord-009571-mygj2nd4 1691 28 % % NN cord-009571-mygj2nd4 1691 29 versus versus IN cord-009571-mygj2nd4 1691 30 85 85 CD cord-009571-mygj2nd4 1691 31 % % NN cord-009571-mygj2nd4 1691 32 ) ) -RRB- cord-009571-mygj2nd4 1691 33 , , , cord-009571-mygj2nd4 1691 34 antinuclear antinuclear JJ cord-009571-mygj2nd4 1691 35 factors factor NNS cord-009571-mygj2nd4 1691 36 ( ( -LRB- cord-009571-mygj2nd4 1691 37 61 61 CD cord-009571-mygj2nd4 1691 38 % % NN cord-009571-mygj2nd4 1691 39 versus versus IN cord-009571-mygj2nd4 1691 40 42 42 CD cord-009571-mygj2nd4 1691 41 % % NN cord-009571-mygj2nd4 1691 42 ) ) -RRB- cord-009571-mygj2nd4 1691 43 , , , cord-009571-mygj2nd4 1691 44 and and CC cord-009571-mygj2nd4 1691 45 hypocomplementemia hypocomplementemia NNP cord-009571-mygj2nd4 1691 46 ( ( -LRB- cord-009571-mygj2nd4 1691 47 13 13 CD cord-009571-mygj2nd4 1691 48 % % NN cord-009571-mygj2nd4 1691 49 versus versus IN cord-009571-mygj2nd4 1691 50 10 10 CD cord-009571-mygj2nd4 1691 51 % % NN cord-009571-mygj2nd4 1691 52 ) ) -RRB- cord-009571-mygj2nd4 1691 53 . . . cord-009571-mygj2nd4 1692 1 There there EX cord-009571-mygj2nd4 1692 2 was be VBD cord-009571-mygj2nd4 1692 3 a a DT cord-009571-mygj2nd4 1692 4 tendency tendency NN cord-009571-mygj2nd4 1692 5 only only RB cord-009571-mygj2nd4 1692 6 for for IN cord-009571-mygj2nd4 1692 7 those those DT cord-009571-mygj2nd4 1692 8 with with IN cord-009571-mygj2nd4 1692 9 SCN SCN NNP cord-009571-mygj2nd4 1692 10 to to TO cord-009571-mygj2nd4 1692 11 have have VB cord-009571-mygj2nd4 1692 12 higher high JJR cord-009571-mygj2nd4 1692 13 Latex latex NN cord-009571-mygj2nd4 1692 14 test test NN cord-009571-mygj2nd4 1692 15 titers titer NNS cord-009571-mygj2nd4 1692 16 . . . cord-009571-mygj2nd4 1693 1 Thus thus RB cord-009571-mygj2nd4 1693 2 , , , cord-009571-mygj2nd4 1693 3 contrary contrary JJ cord-009571-mygj2nd4 1693 4 to to IN cord-009571-mygj2nd4 1693 5 expectations expectation NNS cord-009571-mygj2nd4 1693 6 , , , cord-009571-mygj2nd4 1693 7 subcutaneous subcutaneous JJ cord-009571-mygj2nd4 1693 8 nodules nodule NNS cord-009571-mygj2nd4 1693 9 can can MD cord-009571-mygj2nd4 1693 10 not not RB cord-009571-mygj2nd4 1693 11 be be VB cord-009571-mygj2nd4 1693 12 relied rely VBN cord-009571-mygj2nd4 1693 13 upon upon IN cord-009571-mygj2nd4 1693 14 to to TO cord-009571-mygj2nd4 1693 15 screen screen VB cord-009571-mygj2nd4 1693 16 out out RP cord-009571-mygj2nd4 1693 17 those those DT cord-009571-mygj2nd4 1693 18 patients patient NNS cord-009571-mygj2nd4 1693 19 with with IN cord-009571-mygj2nd4 1693 20 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1693 21 variants variant NNS cord-009571-mygj2nd4 1693 22 and and CC cord-009571-mygj2nd4 1693 23 systemic systemic JJ cord-009571-mygj2nd4 1693 24 disease disease NN cord-009571-mygj2nd4 1693 25 . . . cord-009571-mygj2nd4 1693 26 _SP cord-009571-mygj2nd4 1694 1 Twenty twenty CD cord-009571-mygj2nd4 1694 2 - - HYPH cord-009571-mygj2nd4 1694 3 four four CD cord-009571-mygj2nd4 1694 4 patients patient NNS cord-009571-mygj2nd4 1694 5 ( ( -LRB- cord-009571-mygj2nd4 1694 6 18 18 CD cord-009571-mygj2nd4 1694 7 women woman NNS cord-009571-mygj2nd4 1694 8 , , , cord-009571-mygj2nd4 1694 9 6 6 CD cord-009571-mygj2nd4 1694 10 men man NNS cord-009571-mygj2nd4 1694 11 , , , cord-009571-mygj2nd4 1694 12 mean mean VB cord-009571-mygj2nd4 1694 13 age age NN cord-009571-mygj2nd4 1694 14 54 54 CD cord-009571-mygj2nd4 1695 1 150 150 CD cord-009571-mygj2nd4 1695 2 mg mg NNP cord-009571-mygj2nd4 1695 3 daily daily RB cord-009571-mygj2nd4 1695 4 , , , cord-009571-mygj2nd4 1695 5 versus versus IN cord-009571-mygj2nd4 1695 6 placebo placebo NN cord-009571-mygj2nd4 1695 7 for for IN cord-009571-mygj2nd4 1695 8 6 6 CD cord-009571-mygj2nd4 1695 9 months month NNS cord-009571-mygj2nd4 1695 10 , , , cord-009571-mygj2nd4 1695 11 while while IN cord-009571-mygj2nd4 1695 12 continuing continue VBG cord-009571-mygj2nd4 1695 13 years year NNS cord-009571-mygj2nd4 1695 14 ) ) -RRB- cord-009571-mygj2nd4 1695 15 with with IN cord-009571-mygj2nd4 1695 16 definite definite JJ cord-009571-mygj2nd4 1695 17 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1695 18 arthritis arthritis NN cord-009571-mygj2nd4 1695 19 were be VBD cord-009571-mygj2nd4 1695 20 entered enter VBN cord-009571-mygj2nd4 1695 21 into into IN cord-009571-mygj2nd4 1695 22 a a DT cord-009571-mygj2nd4 1695 23 baseline baseline JJ cord-009571-mygj2nd4 1695 24 non non JJ cord-009571-mygj2nd4 1695 25 - - JJ cord-009571-mygj2nd4 1695 26 steroidal steroidal JJ cord-009571-mygj2nd4 1695 27 antiinflammatory antiinflammatory JJ cord-009571-mygj2nd4 1695 28 therapy therapy NN cord-009571-mygj2nd4 1695 29 and/or and/or CC cord-009571-mygj2nd4 1695 30 preddouble preddouble JJ cord-009571-mygj2nd4 1695 31 - - HYPH cord-009571-mygj2nd4 1695 32 blind blind JJ cord-009571-mygj2nd4 1695 33 study study NN cord-009571-mygj2nd4 1695 34 using use VBG cord-009571-mygj2nd4 1695 35 the the DT cord-009571-mygj2nd4 1695 36 immunomodulator immunomodulator NNP cord-009571-mygj2nd4 1695 37 levamisole levamisole NN cord-009571-mygj2nd4 1695 38 , , , cord-009571-mygj2nd4 1695 39 nisone nisone NN cord-009571-mygj2nd4 1695 40 up up IN cord-009571-mygj2nd4 1695 41 to to TO cord-009571-mygj2nd4 1695 42 10 10 CD cord-009571-mygj2nd4 1695 43 mg mg NN cord-009571-mygj2nd4 1695 44 / / SYM cord-009571-mygj2nd4 1695 45 day day NN cord-009571-mygj2nd4 1695 46 . . . cord-009571-mygj2nd4 1696 1 Assessment assessment NN cord-009571-mygj2nd4 1696 2 criteria criterion NNS cord-009571-mygj2nd4 1696 3 included include VBD cord-009571-mygj2nd4 1696 4 articular articular JJ cord-009571-mygj2nd4 1696 5 index index NN cord-009571-mygj2nd4 1696 6 , , , cord-009571-mygj2nd4 1696 7 grip grip NN cord-009571-mygj2nd4 1696 8 strength strength NN cord-009571-mygj2nd4 1696 9 , , , cord-009571-mygj2nd4 1696 10 50 50 CD cord-009571-mygj2nd4 1696 11 feet foot NNS cord-009571-mygj2nd4 1696 12 walking walk VBG cord-009571-mygj2nd4 1696 13 time time NN cord-009571-mygj2nd4 1696 14 , , , cord-009571-mygj2nd4 1696 15 duration duration NN cord-009571-mygj2nd4 1696 16 of of IN cord-009571-mygj2nd4 1696 17 morning morning NN cord-009571-mygj2nd4 1696 18 stiffness stiffness NN cord-009571-mygj2nd4 1696 19 , , , cord-009571-mygj2nd4 1696 20 subjective subjective JJ cord-009571-mygj2nd4 1696 21 pain pain NN cord-009571-mygj2nd4 1696 22 relief relief NN cord-009571-mygj2nd4 1696 23 , , , cord-009571-mygj2nd4 1696 24 sedimentation sedimentation NN cord-009571-mygj2nd4 1696 25 rate rate NN cord-009571-mygj2nd4 1696 26 , , , cord-009571-mygj2nd4 1696 27 and and CC cord-009571-mygj2nd4 1696 28 latex latex NN cord-009571-mygj2nd4 1696 29 fixation fixation NN cord-009571-mygj2nd4 1696 30 titers titer NNS cord-009571-mygj2nd4 1696 31 . . . cord-009571-mygj2nd4 1697 1 To to IN cord-009571-mygj2nd4 1697 2 date date NN cord-009571-mygj2nd4 1697 3 , , , cord-009571-mygj2nd4 1697 4 21 21 CD cord-009571-mygj2nd4 1697 5 patients patient NNS cord-009571-mygj2nd4 1697 6 have have VBP cord-009571-mygj2nd4 1697 7 completed complete VBN cord-009571-mygj2nd4 1697 8 the the DT cord-009571-mygj2nd4 1697 9 initial initial JJ cord-009571-mygj2nd4 1697 10 phase phase NN cord-009571-mygj2nd4 1697 11 . . . cord-009571-mygj2nd4 1698 1 Eight eight CD cord-009571-mygj2nd4 1698 2 o o NN cord-009571-mygj2nd4 1698 3 f f NN cord-009571-mygj2nd4 1698 4 9 9 CD cord-009571-mygj2nd4 1698 5 on on IN cord-009571-mygj2nd4 1698 6 levamisole levamisole NN cord-009571-mygj2nd4 1698 7 improved improve VBN cord-009571-mygj2nd4 1698 8 while while IN cord-009571-mygj2nd4 1698 9 the the DT cord-009571-mygj2nd4 1698 10 remaining remain VBG cord-009571-mygj2nd4 1698 11 patient patient NN cord-009571-mygj2nd4 1698 12 , , , cord-009571-mygj2nd4 1698 13 who who WP cord-009571-mygj2nd4 1698 14 did do VBD cord-009571-mygj2nd4 1698 15 not not RB cord-009571-mygj2nd4 1698 16 appear appear VB cord-009571-mygj2nd4 1698 17 to to TO cord-009571-mygj2nd4 1698 18 respond respond VB cord-009571-mygj2nd4 1698 19 , , , cord-009571-mygj2nd4 1698 20 flared flare VBD cord-009571-mygj2nd4 1698 21 after after IN cord-009571-mygj2nd4 1698 22 drug drug NN cord-009571-mygj2nd4 1698 23 discontinuation discontinuation NN cord-009571-mygj2nd4 1698 24 . . . cord-009571-mygj2nd4 1699 1 Two two CD cord-009571-mygj2nd4 1699 2 patients patient NNS cord-009571-mygj2nd4 1699 3 on on IN cord-009571-mygj2nd4 1699 4 levamisole levamisole NN cord-009571-mygj2nd4 1699 5 were be VBD cord-009571-mygj2nd4 1699 6 excluded exclude VBN cord-009571-mygj2nd4 1699 7 because because IN cord-009571-mygj2nd4 1699 8 of of IN cord-009571-mygj2nd4 1699 9 skin skin NN cord-009571-mygj2nd4 1699 10 rash rash NN cord-009571-mygj2nd4 1699 11 . . . cord-009571-mygj2nd4 1700 1 Four four CD cord-009571-mygj2nd4 1700 2 of of IN cord-009571-mygj2nd4 1700 3 10 10 CD cord-009571-mygj2nd4 1700 4 on on IN cord-009571-mygj2nd4 1700 5 placebo placebo NN cord-009571-mygj2nd4 1700 6 appeared appear VBD cord-009571-mygj2nd4 1700 7 to to TO cord-009571-mygj2nd4 1700 8 improve improve VB cord-009571-mygj2nd4 1700 9 but but CC cord-009571-mygj2nd4 1700 10 not not RB cord-009571-mygj2nd4 1700 11 to to IN cord-009571-mygj2nd4 1700 12 the the DT cord-009571-mygj2nd4 1700 13 degree degree NN cord-009571-mygj2nd4 1700 14 seen see VBN cord-009571-mygj2nd4 1700 15 with with IN cord-009571-mygj2nd4 1700 16 levamisole levamisole NN cord-009571-mygj2nd4 1700 17 . . . cord-009571-mygj2nd4 1701 1 The the DT cord-009571-mygj2nd4 1701 2 mean mean JJ cord-009571-mygj2nd4 1701 3 changes change NNS cord-009571-mygj2nd4 1701 4 in in IN cord-009571-mygj2nd4 1701 5 articular articular JJ cord-009571-mygj2nd4 1701 6 index index NN cord-009571-mygj2nd4 1701 7 , , , cord-009571-mygj2nd4 1701 8 number number NN cord-009571-mygj2nd4 1701 9 of of IN cord-009571-mygj2nd4 1701 10 swollen swollen JJ cord-009571-mygj2nd4 1701 11 joints joint NNS cord-009571-mygj2nd4 1701 12 , , , cord-009571-mygj2nd4 1701 13 and and CC cord-009571-mygj2nd4 1701 14 duration duration NN cord-009571-mygj2nd4 1701 15 of of IN cord-009571-mygj2nd4 1701 16 morning morning NN cord-009571-mygj2nd4 1701 17 stiffness stiffness NN cord-009571-mygj2nd4 1701 18 were be VBD cord-009571-mygj2nd4 1701 19 statistically statistically RB cord-009571-mygj2nd4 1701 20 significant significant JJ cord-009571-mygj2nd4 1701 21 a a DT cord-009571-mygj2nd4 1701 22 t t NN cord-009571-mygj2nd4 1701 23 6 6 CD cord-009571-mygj2nd4 1701 24 months month NNS cord-009571-mygj2nd4 1701 25 for for IN cord-009571-mygj2nd4 1701 26 levamisole levamisole NN cord-009571-mygj2nd4 1701 27 treated treat VBN cord-009571-mygj2nd4 1701 28 patients patient NNS cord-009571-mygj2nd4 1701 29 but but CC cord-009571-mygj2nd4 1701 30 not not RB cord-009571-mygj2nd4 1701 31 for for IN cord-009571-mygj2nd4 1701 32 placebo placebo NN cord-009571-mygj2nd4 1701 33 ( ( -LRB- cord-009571-mygj2nd4 1701 34 P p NN cord-009571-mygj2nd4 1701 35 < < XX cord-009571-mygj2nd4 1701 36 0.02 0.02 CD cord-009571-mygj2nd4 1701 37 ) ) -RRB- cord-009571-mygj2nd4 1701 38 . . . cord-009571-mygj2nd4 1702 1 Subjective subjective JJ cord-009571-mygj2nd4 1702 2 pain pain NN cord-009571-mygj2nd4 1702 3 scale scale NN cord-009571-mygj2nd4 1702 4 responses response NNS cord-009571-mygj2nd4 1702 5 were be VBD cord-009571-mygj2nd4 1702 6 significantly significantly RB cord-009571-mygj2nd4 1702 7 better well JJR cord-009571-mygj2nd4 1702 8 among among IN cord-009571-mygj2nd4 1702 9 levamisole levamisole NN cord-009571-mygj2nd4 1702 10 versus versus IN cord-009571-mygj2nd4 1702 11 placebo placebo NN cord-009571-mygj2nd4 1702 12 , , , cord-009571-mygj2nd4 1702 13 but but CC cord-009571-mygj2nd4 1702 14 n n NN cord-009571-mygj2nd4 1702 15 o o NN cord-009571-mygj2nd4 1702 16 differences difference NNS cord-009571-mygj2nd4 1702 17 were be VBD cord-009571-mygj2nd4 1702 18 observed observe VBN cord-009571-mygj2nd4 1702 19 between between IN cord-009571-mygj2nd4 1702 20 the the DT cord-009571-mygj2nd4 1702 21 groups group NNS cord-009571-mygj2nd4 1702 22 in in IN cord-009571-mygj2nd4 1702 23 grip grip NN cord-009571-mygj2nd4 1702 24 strength strength NN cord-009571-mygj2nd4 1702 25 or or CC cord-009571-mygj2nd4 1702 26 50 50 CD cord-009571-mygj2nd4 1702 27 feet foot NNS cord-009571-mygj2nd4 1702 28 walking walk VBG cord-009571-mygj2nd4 1702 29 time time NN cord-009571-mygj2nd4 1702 30 . . . cord-009571-mygj2nd4 1703 1 Five five CD cord-009571-mygj2nd4 1703 2 levamisole levamisole RB cord-009571-mygj2nd4 1703 3 treated treat VBD cord-009571-mygj2nd4 1703 4 patients patient NNS cord-009571-mygj2nd4 1703 5 converted convert VBD cord-009571-mygj2nd4 1703 6 to to IN cord-009571-mygj2nd4 1703 7 seronegativity seronegativity NN cord-009571-mygj2nd4 1703 8 after after IN cord-009571-mygj2nd4 1703 9 6 6 CD cord-009571-mygj2nd4 1703 10 months month NNS cord-009571-mygj2nd4 1703 11 . . . cord-009571-mygj2nd4 1704 1 Sedimentation sedimentation NN cord-009571-mygj2nd4 1704 2 rates rate NNS cord-009571-mygj2nd4 1704 3 , , , cord-009571-mygj2nd4 1704 4 however however RB cord-009571-mygj2nd4 1704 5 , , , cord-009571-mygj2nd4 1704 6 remained remain VBD cord-009571-mygj2nd4 1704 7 stable stable JJ cord-009571-mygj2nd4 1704 8 in in IN cord-009571-mygj2nd4 1704 9 both both DT cord-009571-mygj2nd4 1704 10 groups group NNS cord-009571-mygj2nd4 1704 11 : : : cord-009571-mygj2nd4 1704 12 skin skin NN cord-009571-mygj2nd4 1704 13 rashes rash NNS cord-009571-mygj2nd4 1704 14 developed develop VBN cord-009571-mygj2nd4 1704 15 in in IN cord-009571-mygj2nd4 1704 16 5 5 CD cord-009571-mygj2nd4 1704 17 patients patient NNS cord-009571-mygj2nd4 1704 18 on on IN cord-009571-mygj2nd4 1704 19 levamisole levamisole NN cord-009571-mygj2nd4 1704 20 , , , cord-009571-mygj2nd4 1704 21 and and CC cord-009571-mygj2nd4 1704 22 2 2 CD cord-009571-mygj2nd4 1704 23 were be VBD cord-009571-mygj2nd4 1704 24 discontinued discontinue VBN cord-009571-mygj2nd4 1704 25 ; ; : cord-009571-mygj2nd4 1704 26 in in IN cord-009571-mygj2nd4 1704 27 2 2 CD cord-009571-mygj2nd4 1704 28 , , , cord-009571-mygj2nd4 1704 29 rash rash JJ cord-009571-mygj2nd4 1704 30 was be VBD cord-009571-mygj2nd4 1704 31 unrelated unrelated JJ cord-009571-mygj2nd4 1704 32 , , , cord-009571-mygj2nd4 1704 33 and and CC cord-009571-mygj2nd4 1704 34 1 1 CD cord-009571-mygj2nd4 1704 35 continued continue VBD cord-009571-mygj2nd4 1704 36 on on IN cord-009571-mygj2nd4 1704 37 a a DT cord-009571-mygj2nd4 1704 38 lower low JJR cord-009571-mygj2nd4 1704 39 dose dose NN cord-009571-mygj2nd4 1704 40 . . . cord-009571-mygj2nd4 1705 1 Of of IN cord-009571-mygj2nd4 1705 2 interest interest NN cord-009571-mygj2nd4 1705 3 , , , cord-009571-mygj2nd4 1705 4 3 3 CD cord-009571-mygj2nd4 1705 5 of of IN cord-009571-mygj2nd4 1705 6 10 10 CD cord-009571-mygj2nd4 1705 7 on on IN cord-009571-mygj2nd4 1705 8 placebo placebo NN cord-009571-mygj2nd4 1705 9 had have VBD cord-009571-mygj2nd4 1705 10 rashes rash NNS cord-009571-mygj2nd4 1705 11 . . . cord-009571-mygj2nd4 1706 1 Preliminary preliminary JJ cord-009571-mygj2nd4 1706 2 investigations investigation NNS cord-009571-mygj2nd4 1706 3 of of IN cord-009571-mygj2nd4 1706 4 delayed delay VBN cord-009571-mygj2nd4 1706 5 skin skin NN cord-009571-mygj2nd4 1706 6 hypersensitivity hypersensitivity NN cord-009571-mygj2nd4 1706 7 , , , cord-009571-mygj2nd4 1706 8 lymphocyte lymphocyte NN cord-009571-mygj2nd4 1706 9 responsiveness responsiveness NN cord-009571-mygj2nd4 1706 10 , , , cord-009571-mygj2nd4 1706 11 phagocytic phagocytic JJ cord-009571-mygj2nd4 1706 12 function function NN cord-009571-mygj2nd4 1706 13 , , , cord-009571-mygj2nd4 1706 14 and and CC cord-009571-mygj2nd4 1706 15 cutaneous cutaneous JJ cord-009571-mygj2nd4 1706 16 inflammatory inflammatory JJ cord-009571-mygj2nd4 1706 17 responses response NNS cord-009571-mygj2nd4 1706 18 failed fail VBD cord-009571-mygj2nd4 1706 19 to to TO cord-009571-mygj2nd4 1706 20 show show VB cord-009571-mygj2nd4 1706 21 any any DT cord-009571-mygj2nd4 1706 22 correlation correlation NN cord-009571-mygj2nd4 1706 23 with with IN cord-009571-mygj2nd4 1706 24 clinical clinical JJ cord-009571-mygj2nd4 1706 25 responsiveness responsiveness NN cord-009571-mygj2nd4 1706 26 . . . cord-009571-mygj2nd4 1707 1 Levamisole levamisole NN cord-009571-mygj2nd4 1707 2 is be VBZ cord-009571-mygj2nd4 1707 3 a a DT cord-009571-mygj2nd4 1707 4 potentially potentially RB cord-009571-mygj2nd4 1707 5 therapeutic therapeutic JJ cord-009571-mygj2nd4 1707 6 agent agent NN cord-009571-mygj2nd4 1707 7 in in IN cord-009571-mygj2nd4 1707 8 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1707 9 arthritis arthritis NN cord-009571-mygj2nd4 1707 10 , , , cord-009571-mygj2nd4 1707 11 but but CC cord-009571-mygj2nd4 1707 12 its -PRON- PRP$ cord-009571-mygj2nd4 1707 13 mode mode NN cord-009571-mygj2nd4 1707 14 of of IN cord-009571-mygj2nd4 1707 15 action action NN cord-009571-mygj2nd4 1707 16 is be VBZ cord-009571-mygj2nd4 1707 17 yet yet RB cord-009571-mygj2nd4 1707 18 to to TO cord-009571-mygj2nd4 1707 19 be be VB cord-009571-mygj2nd4 1707 20 determined determine VBN cord-009571-mygj2nd4 1707 21 . . . cord-009571-mygj2nd4 1708 1 Since since IN cord-009571-mygj2nd4 1708 2 synovial synovial JJ cord-009571-mygj2nd4 1708 3 fluid fluid NN cord-009571-mygj2nd4 1708 4 cells cell NNS cord-009571-mygj2nd4 1708 5 in in IN cord-009571-mygj2nd4 1708 6 patients patient NNS cord-009571-mygj2nd4 1708 7 with with IN cord-009571-mygj2nd4 1708 8 systemic systemic JJ cord-009571-mygj2nd4 1708 9 lupus lupus NN cord-009571-mygj2nd4 1708 10 erythematosus erythematosus NN cord-009571-mygj2nd4 1708 11 ( ( -LRB- cord-009571-mygj2nd4 1708 12 SLE SLE NNP cord-009571-mygj2nd4 1708 13 ) ) -RRB- cord-009571-mygj2nd4 1708 14 have have VBP cord-009571-mygj2nd4 1708 15 not not RB cord-009571-mygj2nd4 1708 16 previously previously RB cord-009571-mygj2nd4 1708 17 been be VBN cord-009571-mygj2nd4 1708 18 examined examine VBN cord-009571-mygj2nd4 1708 19 by by IN cord-009571-mygj2nd4 1708 20 electron electron NN cord-009571-mygj2nd4 1708 21 microscope microscope NN cord-009571-mygj2nd4 1708 22 , , , cord-009571-mygj2nd4 1708 23 we -PRON- PRP cord-009571-mygj2nd4 1708 24 have have VBP cord-009571-mygj2nd4 1708 25 studied study VBN cord-009571-mygj2nd4 1708 26 17 17 CD cord-009571-mygj2nd4 1708 27 SLE SLE NNP cord-009571-mygj2nd4 1708 28 joint joint JJ cord-009571-mygj2nd4 1708 29 effusions effusion NNS cord-009571-mygj2nd4 1708 30 with with IN cord-009571-mygj2nd4 1708 31 emphasis emphasis NN cord-009571-mygj2nd4 1708 32 on on IN cord-009571-mygj2nd4 1708 33 the the DT cord-009571-mygj2nd4 1708 34 occurrence occurrence NN cord-009571-mygj2nd4 1708 35 of of IN cord-009571-mygj2nd4 1708 36 LE LE NNP cord-009571-mygj2nd4 1708 37 cells cell NNS cord-009571-mygj2nd4 1708 38 and and CC cord-009571-mygj2nd4 1708 39 tubuloreticular tubuloreticular JJ cord-009571-mygj2nd4 1708 40 structures structure NNS cord-009571-mygj2nd4 1708 41 ( ( -LRB- cord-009571-mygj2nd4 1708 42 TRS TRS NNP cord-009571-mygj2nd4 1708 43 ) ) -RRB- cord-009571-mygj2nd4 1708 44 and and CC cord-009571-mygj2nd4 1708 45 on on IN cord-009571-mygj2nd4 1708 46 correlations correlation NNS cord-009571-mygj2nd4 1708 47 with with IN cord-009571-mygj2nd4 1708 48 clinical clinical JJ cord-009571-mygj2nd4 1708 49 and and CC cord-009571-mygj2nd4 1708 50 light light JJ cord-009571-mygj2nd4 1708 51 microscopic microscopic JJ cord-009571-mygj2nd4 1708 52 findings finding NNS cord-009571-mygj2nd4 1708 53 . . . cord-009571-mygj2nd4 1709 1 All all DT cord-009571-mygj2nd4 1709 2 patients patient NNS cord-009571-mygj2nd4 1709 3 fulfilled fulfil VBD cord-009571-mygj2nd4 1709 4 at at IN cord-009571-mygj2nd4 1709 5 least least JJS cord-009571-mygj2nd4 1709 6 4 4 CD cord-009571-mygj2nd4 1709 7 ARA ARA NNP cord-009571-mygj2nd4 1709 8 preliminary preliminary JJ cord-009571-mygj2nd4 1709 9 criteria criterion NNS cord-009571-mygj2nd4 1709 10 for for IN cord-009571-mygj2nd4 1709 11 SLE SLE NNP cord-009571-mygj2nd4 1709 12 and and CC cord-009571-mygj2nd4 1709 13 had have VBD cord-009571-mygj2nd4 1709 14 antinuclear antinuclear JJ cord-009571-mygj2nd4 1709 15 antibodies antibody NNS cord-009571-mygj2nd4 1709 16 in in IN cord-009571-mygj2nd4 1709 17 their -PRON- PRP$ cord-009571-mygj2nd4 1709 18 serum serum NN cord-009571-mygj2nd4 1709 19 . . . cord-009571-mygj2nd4 1710 1 Three three CD cord-009571-mygj2nd4 1710 2 patients patient NNS cord-009571-mygj2nd4 1710 3 had have VBD cord-009571-mygj2nd4 1710 4 drug drug NN cord-009571-mygj2nd4 1710 5 - - HYPH cord-009571-mygj2nd4 1710 6 induced induce VBN cord-009571-mygj2nd4 1710 7 SLE SLE NNP cord-009571-mygj2nd4 1710 8 . . . cord-009571-mygj2nd4 1711 1 Synovial synovial JJ cord-009571-mygj2nd4 1711 2 fluid fluid NN cord-009571-mygj2nd4 1711 3 volumes volume NNS cord-009571-mygj2nd4 1711 4 varied varied JJ cord-009571-mygj2nd4 1711 5 from from IN cord-009571-mygj2nd4 1711 6 0.75 0.75 CD cord-009571-mygj2nd4 1711 7 - - SYM cord-009571-mygj2nd4 1711 8 25 25 CD cord-009571-mygj2nd4 1711 9 cc cc NNS cord-009571-mygj2nd4 1711 10 ; ; : cord-009571-mygj2nd4 1711 11 leukocyte leukocyte NN cord-009571-mygj2nd4 1711 12 counts count NNS cord-009571-mygj2nd4 1711 13 ranged range VBD cord-009571-mygj2nd4 1711 14 from from IN cord-009571-mygj2nd4 1711 15 875 875 CD cord-009571-mygj2nd4 1711 16 - - HYPH cord-009571-mygj2nd4 1711 17 58,000 58,000 CD cord-009571-mygj2nd4 1711 18 but but CC cord-009571-mygj2nd4 1711 19 only only RB cord-009571-mygj2nd4 1711 20 3 3 CD cord-009571-mygj2nd4 1711 21 were be VBD cord-009571-mygj2nd4 1711 22 over over IN cord-009571-mygj2nd4 1711 23 15,000 15,000 CD cord-009571-mygj2nd4 1711 24 . . . cord-009571-mygj2nd4 1712 1 Polymorphonuclear polymorphonuclear JJ cord-009571-mygj2nd4 1712 2 leukocytes leukocyte NNS cord-009571-mygj2nd4 1712 3 predominated predominate VBD cord-009571-mygj2nd4 1712 4 in in IN cord-009571-mygj2nd4 1712 5 3 3 CD cord-009571-mygj2nd4 1712 6 effusions effusion NNS cord-009571-mygj2nd4 1712 7 including include VBG cord-009571-mygj2nd4 1712 8 the the DT cord-009571-mygj2nd4 1712 9 one one CD cord-009571-mygj2nd4 1712 10 with with IN cord-009571-mygj2nd4 1712 11 58,000 58,000 CD cord-009571-mygj2nd4 1712 12 cells cell NNS cord-009571-mygj2nd4 1712 13 . . . cord-009571-mygj2nd4 1713 1 Cultures culture NNS cord-009571-mygj2nd4 1713 2 were be VBD cord-009571-mygj2nd4 1713 3 all all DT cord-009571-mygj2nd4 1713 4 negative negative JJ cord-009571-mygj2nd4 1713 5 . . . cord-009571-mygj2nd4 1714 1 Monocytes monocyte NNS cord-009571-mygj2nd4 1714 2 and and CC cord-009571-mygj2nd4 1714 3 large large JJ cord-009571-mygj2nd4 1714 4 Sudan Sudan NNP cord-009571-mygj2nd4 1714 5 positive positive JJ cord-009571-mygj2nd4 1714 6 macrophages macrophage NNS cord-009571-mygj2nd4 1714 7 were be VBD cord-009571-mygj2nd4 1714 8 prominent prominent JJ cord-009571-mygj2nd4 1714 9 . . . cord-009571-mygj2nd4 1715 1 Joint joint JJ cord-009571-mygj2nd4 1715 2 fluid fluid NN cord-009571-mygj2nd4 1715 3 LE LE NNP cord-009571-mygj2nd4 1715 4 cells cell NNS cord-009571-mygj2nd4 1715 5 were be VBD cord-009571-mygj2nd4 1715 6 found find VBN cord-009571-mygj2nd4 1715 7 in in IN cord-009571-mygj2nd4 1715 8 8 8 CD cord-009571-mygj2nd4 1715 9 patients patient NNS cord-009571-mygj2nd4 1715 10 while while IN cord-009571-mygj2nd4 1715 11 12 12 CD cord-009571-mygj2nd4 1715 12 had have VBD cord-009571-mygj2nd4 1715 13 extracellular extracellular JJ cord-009571-mygj2nd4 1715 14 hematoxylin hematoxylin JJ cord-009571-mygj2nd4 1715 15 bodies body NNS cord-009571-mygj2nd4 1715 16 , , , cord-009571-mygj2nd4 1715 17 and and CC cord-009571-mygj2nd4 1715 18 4 4 CD cord-009571-mygj2nd4 1715 19 had have VBD cord-009571-mygj2nd4 1715 20 a a DT cord-009571-mygj2nd4 1715 21 variety variety NN cord-009571-mygj2nd4 1715 22 of of IN cord-009571-mygj2nd4 1715 23 other other JJ cord-009571-mygj2nd4 1715 24 smaller smaller RBR cord-009571-mygj2nd4 1715 25 eosinophilic eosinophilic JJ cord-009571-mygj2nd4 1715 26 , , , cord-009571-mygj2nd4 1715 27 hematoxyphilic hematoxyphilic JJ cord-009571-mygj2nd4 1715 28 , , , cord-009571-mygj2nd4 1715 29 or or CC cord-009571-mygj2nd4 1715 30 cellular cellular JJ cord-009571-mygj2nd4 1715 31 inclusions inclusion NNS cord-009571-mygj2nd4 1715 32 . . . cord-009571-mygj2nd4 1716 1 LE LE NNP cord-009571-mygj2nd4 1716 2 cells cell NNS cord-009571-mygj2nd4 1716 3 were be VBD cord-009571-mygj2nd4 1716 4 identified identify VBN cord-009571-mygj2nd4 1716 5 by by IN cord-009571-mygj2nd4 1716 6 electron electron NN cord-009571-mygj2nd4 1716 7 microscope microscope NN cord-009571-mygj2nd4 1716 8 in in IN cord-009571-mygj2nd4 1716 9 10 10 CD cord-009571-mygj2nd4 1716 10 patients patient NNS cord-009571-mygj2nd4 1716 11 . . . cord-009571-mygj2nd4 1717 1 The the DT cord-009571-mygj2nd4 1717 2 major major JJ cord-009571-mygj2nd4 1717 3 and and CC cord-009571-mygj2nd4 1717 4 often often RB cord-009571-mygj2nd4 1717 5 sole sole JJ cord-009571-mygj2nd4 1717 6 visible visible JJ cord-009571-mygj2nd4 1717 7 constituent constituent NN cord-009571-mygj2nd4 1717 8 of of IN cord-009571-mygj2nd4 1717 9 the the DT cord-009571-mygj2nd4 1717 10 inclusion inclusion NN cord-009571-mygj2nd4 1717 11 was be VBD cord-009571-mygj2nd4 1717 12 a a DT cord-009571-mygj2nd4 1717 13 clump clump NN cord-009571-mygj2nd4 1717 14 of of IN cord-009571-mygj2nd4 1717 15 short short JJ cord-009571-mygj2nd4 1717 16 filaments filament NNS cord-009571-mygj2nd4 1717 17 about about RB cord-009571-mygj2nd4 1717 18 200 200 CD cord-009571-mygj2nd4 1717 19 nm nm CD cord-009571-mygj2nd4 1717 20 in in IN cord-009571-mygj2nd4 1717 21 diameter diameter NN cord-009571-mygj2nd4 1717 22 . . . cord-009571-mygj2nd4 1718 1 These these DT cord-009571-mygj2nd4 1718 2 lay lie VBD cord-009571-mygj2nd4 1718 3 in in IN cord-009571-mygj2nd4 1718 4 vacuoles vacuole NNS cord-009571-mygj2nd4 1718 5 which which WDT cord-009571-mygj2nd4 1718 6 also also RB cord-009571-mygj2nd4 1718 7 contained contain VBD cord-009571-mygj2nd4 1718 8 acid acid NN cord-009571-mygj2nd4 1718 9 phosphatase phosphatase NN cord-009571-mygj2nd4 1718 10 . . . cord-009571-mygj2nd4 1719 1 These these DT cord-009571-mygj2nd4 1719 2 filaments filament NNS cord-009571-mygj2nd4 1719 3 which which WDT cord-009571-mygj2nd4 1719 4 appear appear VBP cord-009571-mygj2nd4 1719 5 to to TO cord-009571-mygj2nd4 1719 6 be be VB cord-009571-mygj2nd4 1719 7 products product NNS cord-009571-mygj2nd4 1719 8 of of IN cord-009571-mygj2nd4 1719 9 nuclear nuclear JJ cord-009571-mygj2nd4 1719 10 chromatin chromatin NN cord-009571-mygj2nd4 1719 11 also also RB cord-009571-mygj2nd4 1719 12 were be VBD cord-009571-mygj2nd4 1719 13 seen see VBN cord-009571-mygj2nd4 1719 14 extracellularly extracellularly RB cord-009571-mygj2nd4 1719 15 surrounding surround VBG cord-009571-mygj2nd4 1719 16 some some DT cord-009571-mygj2nd4 1719 17 cells cell NNS cord-009571-mygj2nd4 1719 18 and and CC cord-009571-mygj2nd4 1719 19 in in IN cord-009571-mygj2nd4 1719 20 smaller small JJR cord-009571-mygj2nd4 1719 21 vacuoles vacuole NNS cord-009571-mygj2nd4 1719 22 . . . cord-009571-mygj2nd4 1720 1 Small small JJ cord-009571-mygj2nd4 1720 2 acid acid NN cord-009571-mygj2nd4 1720 3 phosphatase phosphatase NN cord-009571-mygj2nd4 1720 4 positive positive JJ cord-009571-mygj2nd4 1720 5 vacuoles vacuole NNS cord-009571-mygj2nd4 1720 6 also also RB cord-009571-mygj2nd4 1720 7 contained contain VBD cord-009571-mygj2nd4 1720 8 cell cell NN cord-009571-mygj2nd4 1720 9 cytoplasmic cytoplasmic JJ cord-009571-mygj2nd4 1720 10 debris debris NN cord-009571-mygj2nd4 1720 11 , , , cord-009571-mygj2nd4 1720 12 intact intact JJ cord-009571-mygj2nd4 1720 13 nucleii nucleii NN cord-009571-mygj2nd4 1720 14 , , , cord-009571-mygj2nd4 1720 15 erythrocyte erythrocyte NN cord-009571-mygj2nd4 1720 16 fragments fragment NNS cord-009571-mygj2nd4 1720 17 , , , cord-009571-mygj2nd4 1720 18 and and CC cord-009571-mygj2nd4 1720 19 large large JJ cord-009571-mygj2nd4 1720 20 amounts amount NNS cord-009571-mygj2nd4 1720 21 of of IN cord-009571-mygj2nd4 1720 22 finely finely RB cord-009571-mygj2nd4 1720 23 granular granular JJ cord-009571-mygj2nd4 1720 24 protein protein NN cord-009571-mygj2nd4 1720 25 - - HYPH cord-009571-mygj2nd4 1720 26 like like JJ cord-009571-mygj2nd4 1720 27 material material NN cord-009571-mygj2nd4 1720 28 . . . cord-009571-mygj2nd4 1721 1 The the DT cord-009571-mygj2nd4 1721 2 finely finely RB cord-009571-mygj2nd4 1721 3 granular granular JJ cord-009571-mygj2nd4 1721 4 material material NN cord-009571-mygj2nd4 1721 5 was be VBD cord-009571-mygj2nd4 1721 6 shown show VBN cord-009571-mygj2nd4 1721 7 t t NNP cord-009571-mygj2nd4 1721 8 o o NN cord-009571-mygj2nd4 1721 9 contain contain VB cord-009571-mygj2nd4 1721 10 IgG IgG NNP cord-009571-mygj2nd4 1721 11 by by IN cord-009571-mygj2nd4 1721 12 immunoperoxidase immunoperoxidase NN cord-009571-mygj2nd4 1721 13 electron electron NN cord-009571-mygj2nd4 1721 14 microscope microscope NN cord-009571-mygj2nd4 1721 15 staining staining NN cord-009571-mygj2nd4 1721 16 . . . cord-009571-mygj2nd4 1722 1 T T NNP cord-009571-mygj2nd4 1722 2 R r NN cord-009571-mygj2nd4 1722 3 S S NNP cord-009571-mygj2nd4 1722 4 were be VBD cord-009571-mygj2nd4 1722 5 found find VBN cord-009571-mygj2nd4 1722 6 in in IN cord-009571-mygj2nd4 1722 7 8 8 CD cord-009571-mygj2nd4 1722 8 synovial synovial JJ cord-009571-mygj2nd4 1722 9 fluids fluid NNS cord-009571-mygj2nd4 1722 10 and and CC cord-009571-mygj2nd4 1722 11 were be VBD cord-009571-mygj2nd4 1722 12 predominantly predominantly RB cord-009571-mygj2nd4 1722 13 in in IN cord-009571-mygj2nd4 1722 14 mononuclear mononuclear JJ cord-009571-mygj2nd4 1722 15 cells cell NNS cord-009571-mygj2nd4 1722 16 with with IN cord-009571-mygj2nd4 1722 17 dense dense JJ cord-009571-mygj2nd4 1722 18 bodies body NNS cord-009571-mygj2nd4 1722 19 and and CC cord-009571-mygj2nd4 1722 20 rough rough JJ cord-009571-mygj2nd4 1722 21 endoplasmic endoplasmic NN cord-009571-mygj2nd4 1722 22 reticulum reticulum NN cord-009571-mygj2nd4 1722 23 . . . cord-009571-mygj2nd4 1723 1 They -PRON- PRP cord-009571-mygj2nd4 1723 2 were be VBD cord-009571-mygj2nd4 1723 3 infrequent infrequent JJ cord-009571-mygj2nd4 1723 4 in in IN cord-009571-mygj2nd4 1723 5 small small JJ cord-009571-mygj2nd4 1723 6 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 1723 7 or or CC cord-009571-mygj2nd4 1723 8 transformed transform VBN cord-009571-mygj2nd4 1723 9 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 1723 10 with with IN cord-009571-mygj2nd4 1723 11 polyribosomes polyribosome NNS cord-009571-mygj2nd4 1723 12 . . . cord-009571-mygj2nd4 1724 1 Two two CD cord-009571-mygj2nd4 1724 2 L l NN cord-009571-mygj2nd4 1724 3 E e NN cord-009571-mygj2nd4 1724 4 cells cell NNS cord-009571-mygj2nd4 1724 5 had have VBD cord-009571-mygj2nd4 1724 6 TRS TRS NNP cord-009571-mygj2nd4 1724 7 . . . cord-009571-mygj2nd4 1725 1 Buffy Buffy NNP cord-009571-mygj2nd4 1725 2 coat coat NN cord-009571-mygj2nd4 1725 3 blood blood NN cord-009571-mygj2nd4 1725 4 cells cell NNS cord-009571-mygj2nd4 1725 5 contained contain VBD cord-009571-mygj2nd4 1725 6 TRS TRS NNP cord-009571-mygj2nd4 1725 7 in in IN cord-009571-mygj2nd4 1725 8 the the DT cord-009571-mygj2nd4 1725 9 2 2 CD cord-009571-mygj2nd4 1725 10 cases case NNS cord-009571-mygj2nd4 1725 11 studied study VBN cord-009571-mygj2nd4 1725 12 . . . cord-009571-mygj2nd4 1726 1 Synovial synovial JJ cord-009571-mygj2nd4 1726 2 fluid fluid JJ cord-009571-mygj2nd4 1726 3 cell cell NN cord-009571-mygj2nd4 1726 4 TRS TRS NNP cord-009571-mygj2nd4 1726 5 were be VBD cord-009571-mygj2nd4 1726 6 seen see VBN cord-009571-mygj2nd4 1726 7 in in IN cord-009571-mygj2nd4 1726 8 2 2 CD cord-009571-mygj2nd4 1726 9 of of IN cord-009571-mygj2nd4 1726 10 130 130 CD cord-009571-mygj2nd4 1726 11 inflammatory inflammatory JJ cord-009571-mygj2nd4 1726 12 and and CC cord-009571-mygj2nd4 1726 13 noninflammatory noninflammatory JJ cord-009571-mygj2nd4 1726 14 synovial synovial JJ cord-009571-mygj2nd4 1726 15 fluid fluid NN cord-009571-mygj2nd4 1726 16 controls control NNS cord-009571-mygj2nd4 1726 17 but but CC cord-009571-mygj2nd4 1726 18 no no DT cord-009571-mygj2nd4 1726 19 control control NN cord-009571-mygj2nd4 1726 20 joint joint JJ cord-009571-mygj2nd4 1726 21 fluids fluid NNS cord-009571-mygj2nd4 1726 22 had have VBD cord-009571-mygj2nd4 1726 23 the the DT cord-009571-mygj2nd4 1726 24 filamentous filamentous JJ cord-009571-mygj2nd4 1726 25 LE LE NNP cord-009571-mygj2nd4 1726 26 inclusions inclusion NNS cord-009571-mygj2nd4 1726 27 seen see VBN cord-009571-mygj2nd4 1726 28 by by IN cord-009571-mygj2nd4 1726 29 electron electron NN cord-009571-mygj2nd4 1726 30 microscope microscope NN cord-009571-mygj2nd4 1726 31 . . . cord-009571-mygj2nd4 1727 1 N n NN cord-009571-mygj2nd4 1727 2 o o NN cord-009571-mygj2nd4 1727 3 correlation correlation NN cord-009571-mygj2nd4 1727 4 of of IN cord-009571-mygj2nd4 1727 5 any any DT cord-009571-mygj2nd4 1727 6 synovial synovial JJ cord-009571-mygj2nd4 1727 7 fluid fluid NN cord-009571-mygj2nd4 1727 8 finding finding NN cord-009571-mygj2nd4 1727 9 with with IN cord-009571-mygj2nd4 1727 10 therapy therapy NN cord-009571-mygj2nd4 1727 11 , , , cord-009571-mygj2nd4 1727 12 effusion effusion NN cord-009571-mygj2nd4 1727 13 duration duration NN cord-009571-mygj2nd4 1727 14 , , , cord-009571-mygj2nd4 1727 15 or or CC cord-009571-mygj2nd4 1727 16 disease disease NN cord-009571-mygj2nd4 1727 17 severity severity NN cord-009571-mygj2nd4 1727 18 has have VBZ cord-009571-mygj2nd4 1727 19 been be VBN cord-009571-mygj2nd4 1727 20 found find VBN cord-009571-mygj2nd4 1727 21 . . . cord-009571-mygj2nd4 1728 1 Synovial synovial JJ cord-009571-mygj2nd4 1728 2 fluids fluid NNS cord-009571-mygj2nd4 1728 3 in in IN cord-009571-mygj2nd4 1728 4 SLE SLE NNP cord-009571-mygj2nd4 1728 5 contain contain VBP cord-009571-mygj2nd4 1728 6 TRS TRS NNP cord-009571-mygj2nd4 1728 7 , , , cord-009571-mygj2nd4 1728 8 many many JJ cord-009571-mygj2nd4 1728 9 phagocytic phagocytic JJ cord-009571-mygj2nd4 1728 10 cells cell NNS cord-009571-mygj2nd4 1728 11 , , , cord-009571-mygj2nd4 1728 12 and and CC cord-009571-mygj2nd4 1728 13 can can MD cord-009571-mygj2nd4 1728 14 have have VB cord-009571-mygj2nd4 1728 15 higher high JJR cord-009571-mygj2nd4 1728 16 leukocyte leukocyte NN cord-009571-mygj2nd4 1728 17 counts count NNS cord-009571-mygj2nd4 1728 18 and and CC cord-009571-mygj2nd4 1728 19 PMN pmn NN cord-009571-mygj2nd4 1728 20 percentages percentage NNS cord-009571-mygj2nd4 1728 21 than than IN cord-009571-mygj2nd4 1728 22 often often RB cord-009571-mygj2nd4 1728 23 appreciated appreciate VBN cord-009571-mygj2nd4 1728 24 . . . cord-009571-mygj2nd4 1729 1 LE LE NNP cord-009571-mygj2nd4 1729 2 inclusions inclusion NNS cord-009571-mygj2nd4 1729 3 in in IN cord-009571-mygj2nd4 1729 4 joint joint JJ cord-009571-mygj2nd4 1729 5 fluid fluid NN cord-009571-mygj2nd4 1729 6 are be VBP cord-009571-mygj2nd4 1729 7 composed compose VBN cord-009571-mygj2nd4 1729 8 predominantly predominantly RB cord-009571-mygj2nd4 1729 9 of of IN cord-009571-mygj2nd4 1729 10 filaments filament NNS cord-009571-mygj2nd4 1729 11 derived derive VBN cord-009571-mygj2nd4 1729 12 from from IN cord-009571-mygj2nd4 1729 13 nuclear nuclear JJ cord-009571-mygj2nd4 1729 14 chromatin chromatin NN cord-009571-mygj2nd4 1729 15 . . . cord-009571-mygj2nd4 1730 1 The the DT cord-009571-mygj2nd4 1730 2 sera sera NN cord-009571-mygj2nd4 1730 3 of of IN cord-009571-mygj2nd4 1730 4 81 81 CD cord-009571-mygj2nd4 1730 5 patients patient NNS cord-009571-mygj2nd4 1730 6 fulfilling fulfil VBG cord-009571-mygj2nd4 1730 7 the the DT cord-009571-mygj2nd4 1730 8 ARA ARA NNP cord-009571-mygj2nd4 1730 9 criteria criterion NNS cord-009571-mygj2nd4 1730 10 for for IN cord-009571-mygj2nd4 1730 11 systemic systemic JJ cord-009571-mygj2nd4 1730 12 lupus lupus NN cord-009571-mygj2nd4 1730 13 erythematosus erythematosus NN cord-009571-mygj2nd4 1730 14 ( ( -LRB- cord-009571-mygj2nd4 1730 15 SLE SLE NNP cord-009571-mygj2nd4 1730 16 ) ) -RRB- cord-009571-mygj2nd4 1730 17 were be VBD cord-009571-mygj2nd4 1730 18 studied study VBN cord-009571-mygj2nd4 1730 19 by by IN cord-009571-mygj2nd4 1730 20 immunodiffusion immunodiffusion NN cord-009571-mygj2nd4 1730 21 and and CC cord-009571-mygj2nd4 1730 22 the the DT cord-009571-mygj2nd4 1730 23 modified modify VBN cord-009571-mygj2nd4 1730 24 Farr Farr NNP cord-009571-mygj2nd4 1730 25 technique technique NN cord-009571-mygj2nd4 1730 26 for for IN cord-009571-mygj2nd4 1730 27 the the DT cord-009571-mygj2nd4 1730 28 presence presence NN cord-009571-mygj2nd4 1730 29 of of IN cord-009571-mygj2nd4 1730 30 antibodies antibody NNS cord-009571-mygj2nd4 1730 31 to to IN cord-009571-mygj2nd4 1730 32 the the DT cord-009571-mygj2nd4 1730 33 following follow VBG cord-009571-mygj2nd4 1730 34 antigens antigen NNS cord-009571-mygj2nd4 1730 35 : : : cord-009571-mygj2nd4 1730 36 SS SS NNP cord-009571-mygj2nd4 1730 37 - - HYPH cord-009571-mygj2nd4 1730 38 A A NNP cord-009571-mygj2nd4 1730 39 , , , cord-009571-mygj2nd4 1730 40 SS SS NNP cord-009571-mygj2nd4 1730 41 - - HYPH cord-009571-mygj2nd4 1730 42 B B NNP cord-009571-mygj2nd4 1730 43 , , , cord-009571-mygj2nd4 1730 44 RANA RANA NNP cord-009571-mygj2nd4 1730 45 ( ( -LRB- cord-009571-mygj2nd4 1730 46 RAP RAP NNP cord-009571-mygj2nd4 1730 47 antigen antigen NNP cord-009571-mygj2nd4 1730 48 ) ) -RRB- cord-009571-mygj2nd4 1730 49 , , , cord-009571-mygj2nd4 1730 50 RNP RNP NNP cord-009571-mygj2nd4 1730 51 , , , cord-009571-mygj2nd4 1730 52 Sm Sm NNP cord-009571-mygj2nd4 1730 53 , , , cord-009571-mygj2nd4 1730 54 Scl-1 Scl-1 NNP cord-009571-mygj2nd4 1730 55 , , , cord-009571-mygj2nd4 1730 56 and and CC cord-009571-mygj2nd4 1730 57 DS DS NNP cord-009571-mygj2nd4 1730 58 - - HYPH cord-009571-mygj2nd4 1730 59 DNA DNA NNP cord-009571-mygj2nd4 1730 60 . . . cord-009571-mygj2nd4 1731 1 The the DT cord-009571-mygj2nd4 1731 2 incidence incidence NN cord-009571-mygj2nd4 1731 3 of of IN cord-009571-mygj2nd4 1731 4 antibodies antibody NNS cord-009571-mygj2nd4 1731 5 to to IN cord-009571-mygj2nd4 1731 6 SS SS NNP cord-009571-mygj2nd4 1731 7 - - HYPH cord-009571-mygj2nd4 1731 8 B B NNP cord-009571-mygj2nd4 1731 9 , , , cord-009571-mygj2nd4 1731 10 RNP RNP NNP cord-009571-mygj2nd4 1731 11 , , , cord-009571-mygj2nd4 1731 12 Sm Sm NNP cord-009571-mygj2nd4 1731 13 , , , cord-009571-mygj2nd4 1731 14 and and CC cord-009571-mygj2nd4 1731 15 DS DS NNP cord-009571-mygj2nd4 1731 16 - - HYPH cord-009571-mygj2nd4 1731 17 DNA DNA NNP cord-009571-mygj2nd4 1731 18 was be VBD cord-009571-mygj2nd4 1731 19 similar similar JJ cord-009571-mygj2nd4 1731 20 to to IN cord-009571-mygj2nd4 1731 21 those those DT cord-009571-mygj2nd4 1731 22 previously previously RB cord-009571-mygj2nd4 1731 23 reported report VBN cord-009571-mygj2nd4 1731 24 . . . cord-009571-mygj2nd4 1732 1 The the DT cord-009571-mygj2nd4 1732 2 incidence incidence NN cord-009571-mygj2nd4 1732 3 of of IN cord-009571-mygj2nd4 1732 4 anti anti JJ cord-009571-mygj2nd4 1732 5 - - JJ cord-009571-mygj2nd4 1732 6 Scl Scl NNP cord-009571-mygj2nd4 1732 7 - - HYPH cord-009571-mygj2nd4 1732 8 l l NNP cord-009571-mygj2nd4 1732 9 antibody antibody NN cord-009571-mygj2nd4 1732 10 was be VBD cord-009571-mygj2nd4 1732 11 0 0 CD cord-009571-mygj2nd4 1732 12 % % NN cord-009571-mygj2nd4 1732 13 , , , cord-009571-mygj2nd4 1732 14 a a DT cord-009571-mygj2nd4 1732 15 finding finding NN cord-009571-mygj2nd4 1732 16 which which WDT cord-009571-mygj2nd4 1732 17 has have VBZ cord-009571-mygj2nd4 1732 18 not not RB cord-009571-mygj2nd4 1732 19 been be VBN cord-009571-mygj2nd4 1732 20 reported report VBN cord-009571-mygj2nd4 1732 21 pre pre NNS cord-009571-mygj2nd4 1732 22 - - NN cord-009571-mygj2nd4 1732 23 viously viously RB cord-009571-mygj2nd4 1732 24 . . . cord-009571-mygj2nd4 1733 1 The the DT cord-009571-mygj2nd4 1733 2 incidence incidence NN cord-009571-mygj2nd4 1733 3 of of IN cord-009571-mygj2nd4 1733 4 R r NN cord-009571-mygj2nd4 1733 5 A a NN cord-009571-mygj2nd4 1733 6 P p NN cord-009571-mygj2nd4 1733 7 ( ( -LRB- cord-009571-mygj2nd4 1733 8 23 23 CD cord-009571-mygj2nd4 1733 9 % % NN cord-009571-mygj2nd4 1733 10 ) ) -RRB- cord-009571-mygj2nd4 1733 11 was be VBD cord-009571-mygj2nd4 1733 12 higher high JJR cord-009571-mygj2nd4 1733 13 than than IN cord-009571-mygj2nd4 1733 14 the the DT cord-009571-mygj2nd4 1733 15 7 7 CD cord-009571-mygj2nd4 1733 16 % % NN cord-009571-mygj2nd4 1733 17 previously previously RB cord-009571-mygj2nd4 1733 18 reported report VBN cord-009571-mygj2nd4 1733 19 . . . cord-009571-mygj2nd4 1734 1 The the DT cord-009571-mygj2nd4 1734 2 incidence incidence NN cord-009571-mygj2nd4 1734 3 of of IN cord-009571-mygj2nd4 1734 4 anti anti JJ cord-009571-mygj2nd4 1734 5 - - JJ cord-009571-mygj2nd4 1734 6 SS SS NNP cord-009571-mygj2nd4 1734 7 - - HYPH cord-009571-mygj2nd4 1734 8 A a DT cord-009571-mygj2nd4 1734 9 antibody antibody NN cord-009571-mygj2nd4 1734 10 was be VBD cord-009571-mygj2nd4 1734 11 26 26 CD cord-009571-mygj2nd4 1734 12 % % NN cord-009571-mygj2nd4 1734 13 . . . cord-009571-mygj2nd4 1735 1 This this DT cord-009571-mygj2nd4 1735 2 antibody antibody NN cord-009571-mygj2nd4 1735 3 was be VBD cord-009571-mygj2nd4 1735 4 found find VBN cord-009571-mygj2nd4 1735 5 in in IN cord-009571-mygj2nd4 1735 6 high high JJ cord-009571-mygj2nd4 1735 7 frequency frequency NN cord-009571-mygj2nd4 1735 8 in in IN cord-009571-mygj2nd4 1735 9 primary primary JJ cord-009571-mygj2nd4 1735 10 SjBgren SjBgren NNP cord-009571-mygj2nd4 1735 11 's 's POS cord-009571-mygj2nd4 1735 12 syndrome syndrome NN cord-009571-mygj2nd4 1735 13 ( ( -LRB- cord-009571-mygj2nd4 1735 14 70 70 CD cord-009571-mygj2nd4 1735 15 % % NN cord-009571-mygj2nd4 1735 16 ) ) -RRB- cord-009571-mygj2nd4 1735 17 in in IN cord-009571-mygj2nd4 1735 18 the the DT cord-009571-mygj2nd4 1735 19 past past NN cord-009571-mygj2nd4 1735 20 but but CC cord-009571-mygj2nd4 1735 21 was be VBD cord-009571-mygj2nd4 1735 22 not not RB cord-009571-mygj2nd4 1735 23 found find VBN cord-009571-mygj2nd4 1735 24 in in IN cord-009571-mygj2nd4 1735 25 the the DT cord-009571-mygj2nd4 1735 26 small small JJ cord-009571-mygj2nd4 1735 27 number number NN cord-009571-mygj2nd4 1735 28 of of IN cord-009571-mygj2nd4 1735 29 SLE SLE NNP cord-009571-mygj2nd4 1735 30 patients patient NNS cord-009571-mygj2nd4 1735 31 studied study VBD cord-009571-mygj2nd4 1735 32 at at IN cord-009571-mygj2nd4 1735 33 that that DT cord-009571-mygj2nd4 1735 34 time time NN cord-009571-mygj2nd4 1735 35 . . . cord-009571-mygj2nd4 1736 1 In in IN cord-009571-mygj2nd4 1736 2 this this DT cord-009571-mygj2nd4 1736 3 study study NN cord-009571-mygj2nd4 1736 4 where where WRB cord-009571-mygj2nd4 1736 5 a a DT cord-009571-mygj2nd4 1736 6 large large JJ cord-009571-mygj2nd4 1736 7 number number NN cord-009571-mygj2nd4 1736 8 of of IN cord-009571-mygj2nd4 1736 9 SLE SLE NNP cord-009571-mygj2nd4 1736 10 patients patient NNS cord-009571-mygj2nd4 1736 11 were be VBD cord-009571-mygj2nd4 1736 12 studied study VBN cord-009571-mygj2nd4 1736 13 and and CC cord-009571-mygj2nd4 1736 14 anti anti JJ cord-009571-mygj2nd4 1736 15 - - JJ cord-009571-mygj2nd4 1736 16 SS ss JJ cord-009571-mygj2nd4 1736 17 - - HYPH cord-009571-mygj2nd4 1736 18 A a DT cord-009571-mygj2nd4 1736 19 antibody antibody NN cord-009571-mygj2nd4 1736 20 was be VBD cord-009571-mygj2nd4 1736 21 present present JJ cord-009571-mygj2nd4 1736 22 , , , cord-009571-mygj2nd4 1736 23 only only RB cord-009571-mygj2nd4 1736 24 48 48 CD cord-009571-mygj2nd4 1736 25 % % NN cord-009571-mygj2nd4 1736 26 had have VBD cord-009571-mygj2nd4 1736 27 any any DT cord-009571-mygj2nd4 1736 28 evidence evidence NN cord-009571-mygj2nd4 1736 29 of of IN cord-009571-mygj2nd4 1736 30 keratoconjunctivitis keratoconjunctivitis NNP cord-009571-mygj2nd4 1736 31 sicca sicca NNP cord-009571-mygj2nd4 1736 32 based base VBN cord-009571-mygj2nd4 1736 33 on on IN cord-009571-mygj2nd4 1736 34 Schirmer Schirmer NNP cord-009571-mygj2nd4 1736 35 's 's POS cord-009571-mygj2nd4 1736 36 tests test NNS cord-009571-mygj2nd4 1736 37 . . . cord-009571-mygj2nd4 1737 1 This this DT cord-009571-mygj2nd4 1737 2 indicates indicate VBZ cord-009571-mygj2nd4 1737 3 that that IN cord-009571-mygj2nd4 1737 4 not not RB cord-009571-mygj2nd4 1737 5 only only RB cord-009571-mygj2nd4 1737 6 is be VBZ cord-009571-mygj2nd4 1737 7 anti anti JJ cord-009571-mygj2nd4 1737 8 - - JJ cord-009571-mygj2nd4 1737 9 SS SS NNP cord-009571-mygj2nd4 1737 10 - - HYPH cord-009571-mygj2nd4 1737 11 A a NN cord-009571-mygj2nd4 1737 12 an an DT cord-009571-mygj2nd4 1737 13 antibody antibody NN cord-009571-mygj2nd4 1737 14 " " `` cord-009571-mygj2nd4 1737 15 marker marker NN cord-009571-mygj2nd4 1737 16 " " '' cord-009571-mygj2nd4 1737 17 for for IN cord-009571-mygj2nd4 1737 18 primary primary JJ cord-009571-mygj2nd4 1737 19 Sjogren Sjogren NNP cord-009571-mygj2nd4 1737 20 's 's POS cord-009571-mygj2nd4 1737 21 syndrome syndrome NN cord-009571-mygj2nd4 1737 22 , , , cord-009571-mygj2nd4 1737 23 but but CC cord-009571-mygj2nd4 1737 24 it -PRON- PRP cord-009571-mygj2nd4 1737 25 is be VBZ cord-009571-mygj2nd4 1737 26 relatively relatively RB cord-009571-mygj2nd4 1737 27 common common JJ cord-009571-mygj2nd4 1737 28 in in IN cord-009571-mygj2nd4 1737 29 SLE SLE NNP cord-009571-mygj2nd4 1737 30 as as RB cord-009571-mygj2nd4 1737 31 well well RB cord-009571-mygj2nd4 1737 32 and and CC cord-009571-mygj2nd4 1737 33 furthermore furthermore RB cord-009571-mygj2nd4 1737 34 , , , cord-009571-mygj2nd4 1737 35 can can MD cord-009571-mygj2nd4 1737 36 exist exist VB cord-009571-mygj2nd4 1737 37 in in IN cord-009571-mygj2nd4 1737 38 SLE SLE NNP cord-009571-mygj2nd4 1737 39 in in IN cord-009571-mygj2nd4 1737 40 the the DT cord-009571-mygj2nd4 1737 41 absence absence NN cord-009571-mygj2nd4 1737 42 of of IN cord-009571-mygj2nd4 1737 43 keratoconjunctivitis keratoconjunctivitis NNP cord-009571-mygj2nd4 1737 44 sicca sicca NNP cord-009571-mygj2nd4 1737 45 . . . cord-009571-mygj2nd4 1738 1 Serial serial JJ cord-009571-mygj2nd4 1738 2 studies study NNS cord-009571-mygj2nd4 1738 3 were be VBD cord-009571-mygj2nd4 1738 4 also also RB cord-009571-mygj2nd4 1738 5 performed perform VBN cord-009571-mygj2nd4 1738 6 on on IN cord-009571-mygj2nd4 1738 7 some some DT cord-009571-mygj2nd4 1738 8 patients patient NNS cord-009571-mygj2nd4 1738 9 . . . cord-009571-mygj2nd4 1739 1 Titers Titers NNP cord-009571-mygj2nd4 1739 2 of of IN cord-009571-mygj2nd4 1739 3 anti anti JJ cord-009571-mygj2nd4 1739 4 - - JJ cord-009571-mygj2nd4 1739 5 SS SS NNP cord-009571-mygj2nd4 1739 6 - - HYPH cord-009571-mygj2nd4 1739 7 A a DT cord-009571-mygj2nd4 1739 8 antibody antibody NN cord-009571-mygj2nd4 1739 9 were be VBD cord-009571-mygj2nd4 1739 10 determined determine VBN cord-009571-mygj2nd4 1739 11 . . . cord-009571-mygj2nd4 1740 1 These these DT cord-009571-mygj2nd4 1740 2 varied varied JJ cord-009571-mygj2nd4 1740 3 from from IN cord-009571-mygj2nd4 1740 4 neat neat JJ cord-009571-mygj2nd4 1740 5 to to IN cord-009571-mygj2nd4 1740 6 2048 2048 CD cord-009571-mygj2nd4 1740 7 and and CC cord-009571-mygj2nd4 1740 8 correlated correlate VBN cord-009571-mygj2nd4 1740 9 with with IN cord-009571-mygj2nd4 1740 10 disease disease NN cord-009571-mygj2nd4 1740 11 activity activity NN cord-009571-mygj2nd4 1740 12 . . . cord-009571-mygj2nd4 1741 1 Anti anti JJ cord-009571-mygj2nd4 1741 2 - - JJ cord-009571-mygj2nd4 1741 3 SS SS NNP cord-009571-mygj2nd4 1741 4 - - HYPH cord-009571-mygj2nd4 1741 5 A A NNP cord-009571-mygj2nd4 1741 6 often often RB cord-009571-mygj2nd4 1741 7 paralleled parallel VBN cord-009571-mygj2nd4 1741 8 anti anti JJ cord-009571-mygj2nd4 1741 9 - - JJ cord-009571-mygj2nd4 1741 10 DS ds JJ cord-009571-mygj2nd4 1741 11 - - HYPH cord-009571-mygj2nd4 1741 12 DNA dna NN cord-009571-mygj2nd4 1741 13 levels level NNS cord-009571-mygj2nd4 1741 14 ; ; : cord-009571-mygj2nd4 1741 15 however however RB cord-009571-mygj2nd4 1741 16 , , , cord-009571-mygj2nd4 1741 17 anti anti JJ cord-009571-mygj2nd4 1741 18 - - JJ cord-009571-mygj2nd4 1741 19 SS SS NNP cord-009571-mygj2nd4 1741 20 - - HYPH cord-009571-mygj2nd4 1741 21 A a NN cord-009571-mygj2nd4 1741 22 in in IN cord-009571-mygj2nd4 1741 23 some some DT cord-009571-mygj2nd4 1741 24 cases case NNS cord-009571-mygj2nd4 1741 25 was be VBD cord-009571-mygj2nd4 1741 26 an an DT cord-009571-mygj2nd4 1741 27 earlier early JJR cord-009571-mygj2nd4 1741 28 predictor predictor NN cord-009571-mygj2nd4 1741 29 of of IN cord-009571-mygj2nd4 1741 30 clinical clinical JJ cord-009571-mygj2nd4 1741 31 flares flare NNS cord-009571-mygj2nd4 1741 32 . . . cord-009571-mygj2nd4 1742 1 Thus thus RB cord-009571-mygj2nd4 1742 2 , , , cord-009571-mygj2nd4 1742 3 anti anti JJ cord-009571-mygj2nd4 1742 4 - - JJ cord-009571-mygj2nd4 1742 5 SS ss JJ cord-009571-mygj2nd4 1742 6 - - HYPH cord-009571-mygj2nd4 1742 7 A a DT cord-009571-mygj2nd4 1742 8 antibody antibody NN cord-009571-mygj2nd4 1742 9 may may MD cord-009571-mygj2nd4 1742 10 be be VB cord-009571-mygj2nd4 1742 11 helpful helpful JJ cord-009571-mygj2nd4 1742 12 not not RB cord-009571-mygj2nd4 1742 13 only only RB cord-009571-mygj2nd4 1742 14 in in IN cord-009571-mygj2nd4 1742 15 the the DT cord-009571-mygj2nd4 1742 16 management management NN cord-009571-mygj2nd4 1742 17 of of IN cord-009571-mygj2nd4 1742 18 SLE SLE NNP cord-009571-mygj2nd4 1742 19 patients patient NNS cord-009571-mygj2nd4 1742 20 , , , cord-009571-mygj2nd4 1742 21 but but CC cord-009571-mygj2nd4 1742 22 with with IN cord-009571-mygj2nd4 1742 23 further further JJ cord-009571-mygj2nd4 1742 24 investigation investigation NN cord-009571-mygj2nd4 1742 25 , , , cord-009571-mygj2nd4 1742 26 aid aid NN cord-009571-mygj2nd4 1742 27 in in IN cord-009571-mygj2nd4 1742 28 determining determine VBG cord-009571-mygj2nd4 1742 29 the the DT cord-009571-mygj2nd4 1742 30 pathogenesis pathogenesis NN cord-009571-mygj2nd4 1742 31 of of IN cord-009571-mygj2nd4 1742 32 this this DT cord-009571-mygj2nd4 1742 33 disease disease NN cord-009571-mygj2nd4 1742 34 . . . cord-009571-mygj2nd4 1743 1 The the DT cord-009571-mygj2nd4 1743 2 phenanthridine phenanthridine NN cord-009571-mygj2nd4 1743 3 dye dye NN cord-009571-mygj2nd4 1743 4 ethidium ethidium NN cord-009571-mygj2nd4 1743 5 bromide bromide NN cord-009571-mygj2nd4 1743 6 ( ( -LRB- cord-009571-mygj2nd4 1743 7 EB EB NNP cord-009571-mygj2nd4 1743 8 ) ) -RRB- cord-009571-mygj2nd4 1743 9 intercalates intercalates NNPS cord-009571-mygj2nd4 1743 10 with with IN cord-009571-mygj2nd4 1743 11 native native JJ cord-009571-mygj2nd4 1743 12 double double RB cord-009571-mygj2nd4 1743 13 - - HYPH cord-009571-mygj2nd4 1743 14 stranded stranded JJ cord-009571-mygj2nd4 1743 15 D D NNP cord-009571-mygj2nd4 1743 16 N n NN cord-009571-mygj2nd4 1743 17 A a NN cord-009571-mygj2nd4 1743 18 ( ( -LRB- cord-009571-mygj2nd4 1743 19 dsDNA dsdna NN cord-009571-mygj2nd4 1743 20 ) ) -RRB- cord-009571-mygj2nd4 1743 21 resulting result VBG cord-009571-mygj2nd4 1743 22 in in IN cord-009571-mygj2nd4 1743 23 an an DT cord-009571-mygj2nd4 1743 24 enhancement enhancement NN cord-009571-mygj2nd4 1743 25 of of IN cord-009571-mygj2nd4 1743 26 fluorescence fluorescence NN cord-009571-mygj2nd4 1743 27 when when WRB cord-009571-mygj2nd4 1743 28 assayed assay VBN cord-009571-mygj2nd4 1743 29 fluorometrically fluorometrically RB cord-009571-mygj2nd4 1743 30 . . . cord-009571-mygj2nd4 1744 1 Contamination contamination NN cord-009571-mygj2nd4 1744 2 of of IN cord-009571-mygj2nd4 1744 3 dsDNA dsdna JJ cord-009571-mygj2nd4 1744 4 preparations preparation NNS cord-009571-mygj2nd4 1744 5 by by IN cord-009571-mygj2nd4 1744 6 singlestranded singlestranded JJ cord-009571-mygj2nd4 1744 7 DNA DNA NNP cord-009571-mygj2nd4 1744 8 ( ( -LRB- cord-009571-mygj2nd4 1744 9 ssDNA ssdna NN cord-009571-mygj2nd4 1744 10 ) ) -RRB- cord-009571-mygj2nd4 1744 11 does do VBZ cord-009571-mygj2nd4 1744 12 not not RB cord-009571-mygj2nd4 1744 13 affect affect VB cord-009571-mygj2nd4 1744 14 the the DT cord-009571-mygj2nd4 1744 15 assay assay NN cord-009571-mygj2nd4 1744 16 because because IN cord-009571-mygj2nd4 1744 17 there there EX cord-009571-mygj2nd4 1744 18 is be VBZ cord-009571-mygj2nd4 1744 19 no no DT cord-009571-mygj2nd4 1744 20 fluorescence fluorescence NN cord-009571-mygj2nd4 1744 21 enhancement enhancement NN cord-009571-mygj2nd4 1744 22 when when WRB cord-009571-mygj2nd4 1744 23 ssDNA ssdna NN cord-009571-mygj2nd4 1744 24 is be VBZ cord-009571-mygj2nd4 1744 25 added add VBN cord-009571-mygj2nd4 1744 26 to to IN cord-009571-mygj2nd4 1744 27 EB EB NNP cord-009571-mygj2nd4 1744 28 . . . cord-009571-mygj2nd4 1745 1 IgG IgG NNP cord-009571-mygj2nd4 1745 2 purified purify VBN cord-009571-mygj2nd4 1745 3 by by IN cord-009571-mygj2nd4 1745 4 DEAE DEAE NNP cord-009571-mygj2nd4 1745 5 column column NN cord-009571-mygj2nd4 1745 6 chromatography chromatography NN cord-009571-mygj2nd4 1745 7 from from IN cord-009571-mygj2nd4 1745 8 the the DT cord-009571-mygj2nd4 1745 9 sera sera NNP cord-009571-mygj2nd4 1745 10 of of IN cord-009571-mygj2nd4 1745 11 10 10 CD cord-009571-mygj2nd4 1745 12 normal normal JJ cord-009571-mygj2nd4 1745 13 volunteers volunteer NNS cord-009571-mygj2nd4 1745 14 : : : cord-009571-mygj2nd4 1746 1 19 19 CD cord-009571-mygj2nd4 1746 2 systemic systemic JJ cord-009571-mygj2nd4 1746 3 lupus lupus NN cord-009571-mygj2nd4 1746 4 erythematosus erythematosus NN cord-009571-mygj2nd4 1746 5 ( ( -LRB- cord-009571-mygj2nd4 1746 6 SLE SLE NNP cord-009571-mygj2nd4 1746 7 ) ) -RRB- cord-009571-mygj2nd4 1746 8 sera sera NNP cord-009571-mygj2nd4 1746 9 with with IN cord-009571-mygj2nd4 1746 10 D D NNP cord-009571-mygj2nd4 1746 11 N N NNP cord-009571-mygj2nd4 1746 12 A a DT cord-009571-mygj2nd4 1746 13 binding binding JJ cord-009571-mygj2nd4 1746 14 activity activity NN cord-009571-mygj2nd4 1746 15 as as IN cord-009571-mygj2nd4 1746 16 measured measure VBN cord-009571-mygj2nd4 1746 17 by by IN cord-009571-mygj2nd4 1746 18 the the DT cord-009571-mygj2nd4 1746 19 Millipore Millipore NNP cord-009571-mygj2nd4 1746 20 filter filter NN cord-009571-mygj2nd4 1746 21 ( ( -LRB- cord-009571-mygj2nd4 1746 22 MPF MPF NNP cord-009571-mygj2nd4 1746 23 ) ) -RRB- cord-009571-mygj2nd4 1746 24 radioimmunoassay radioimmunoassay NN cord-009571-mygj2nd4 1746 25 , , , cord-009571-mygj2nd4 1746 26 and and CC cord-009571-mygj2nd4 1746 27 5 5 CD cord-009571-mygj2nd4 1746 28 SLE SLE NNP cord-009571-mygj2nd4 1746 29 sera sera NNP cord-009571-mygj2nd4 1746 30 without without IN cord-009571-mygj2nd4 1746 31 D D NNP cord-009571-mygj2nd4 1746 32 N n CD cord-009571-mygj2nd4 1747 1 A a DT cord-009571-mygj2nd4 1747 2 binding binding JJ cord-009571-mygj2nd4 1747 3 activity activity NN cord-009571-mygj2nd4 1747 4 were be VBD cord-009571-mygj2nd4 1747 5 tested test VBN cord-009571-mygj2nd4 1747 6 for for IN cord-009571-mygj2nd4 1747 7 their -PRON- PRP$ cord-009571-mygj2nd4 1747 8 ability ability NN cord-009571-mygj2nd4 1747 9 to to TO cord-009571-mygj2nd4 1747 10 compete compete VB cord-009571-mygj2nd4 1747 11 with with IN cord-009571-mygj2nd4 1747 12 EB EB NNP cord-009571-mygj2nd4 1747 13 for for IN cord-009571-mygj2nd4 1747 14 binding bind VBG cord-009571-mygj2nd4 1747 15 to to IN cord-009571-mygj2nd4 1747 16 dsDNA dsdna RB cord-009571-mygj2nd4 1747 17 . . . cord-009571-mygj2nd4 1748 1 In in IN cord-009571-mygj2nd4 1748 2 18 18 CD cord-009571-mygj2nd4 1748 3 of of IN cord-009571-mygj2nd4 1748 4 19 19 CD cord-009571-mygj2nd4 1748 5 of of IN cord-009571-mygj2nd4 1748 6 the the DT cord-009571-mygj2nd4 1748 7 SLE SLE NNP cord-009571-mygj2nd4 1748 8 with with IN cord-009571-mygj2nd4 1748 9 MPF MPF NNP cord-009571-mygj2nd4 1748 10 - - HYPH cord-009571-mygj2nd4 1748 11 DNA dna NN cord-009571-mygj2nd4 1748 12 binding binding NN cord-009571-mygj2nd4 1748 13 activity activity NN cord-009571-mygj2nd4 1748 14 , , , cord-009571-mygj2nd4 1748 15 there there EX cord-009571-mygj2nd4 1748 16 was be VBD cord-009571-mygj2nd4 1749 1 greater great JJR cord-009571-mygj2nd4 1749 2 than than IN cord-009571-mygj2nd4 1749 3 2090 2090 CD cord-009571-mygj2nd4 1749 4 inhibition inhibition NN cord-009571-mygj2nd4 1749 5 of of IN cord-009571-mygj2nd4 1749 6 the the DT cord-009571-mygj2nd4 1749 7 fluorescence fluorescence NN cord-009571-mygj2nd4 1749 8 normally normally RB cord-009571-mygj2nd4 1749 9 shown show VBN cord-009571-mygj2nd4 1749 10 when when WRB cord-009571-mygj2nd4 1749 11 EB EB NNP cord-009571-mygj2nd4 1749 12 binds bind VBZ cord-009571-mygj2nd4 1749 13 dsDNA dsdna RB cord-009571-mygj2nd4 1749 14 . . . cord-009571-mygj2nd4 1750 1 In in IN cord-009571-mygj2nd4 1750 2 contrast contrast NN cord-009571-mygj2nd4 1750 3 , , , cord-009571-mygj2nd4 1750 4 0 0 CD cord-009571-mygj2nd4 1750 5 of of IN cord-009571-mygj2nd4 1750 6 10 10 CD cord-009571-mygj2nd4 1750 7 control control NN cord-009571-mygj2nd4 1750 8 IgG igg NN cord-009571-mygj2nd4 1750 9 preparations preparation NNS cord-009571-mygj2nd4 1750 10 and and CC cord-009571-mygj2nd4 1750 11 0 0 CD cord-009571-mygj2nd4 1750 12 of of IN cord-009571-mygj2nd4 1750 13 5 5 CD cord-009571-mygj2nd4 1750 14 of of IN cord-009571-mygj2nd4 1750 15 the the DT cord-009571-mygj2nd4 1750 16 SLE SLE NNP cord-009571-mygj2nd4 1750 17 IgG igg NN cord-009571-mygj2nd4 1750 18 from from IN cord-009571-mygj2nd4 1750 19 non non JJ cord-009571-mygj2nd4 1750 20 - - JJ cord-009571-mygj2nd4 1750 21 DNA dna JJ cord-009571-mygj2nd4 1750 22 binders binder NNS cord-009571-mygj2nd4 1750 23 had have VBD cord-009571-mygj2nd4 1750 24 any any DT cord-009571-mygj2nd4 1750 25 such such JJ cord-009571-mygj2nd4 1750 26 effect effect NN cord-009571-mygj2nd4 1750 27 . . . cord-009571-mygj2nd4 1751 1 Furthermore furthermore RB cord-009571-mygj2nd4 1751 2 , , , cord-009571-mygj2nd4 1751 3 the the DT cord-009571-mygj2nd4 1751 4 decrease decrease NN cord-009571-mygj2nd4 1751 5 in in IN cord-009571-mygj2nd4 1751 6 fluorescence fluorescence NN cord-009571-mygj2nd4 1751 7 due due IN cord-009571-mygj2nd4 1751 8 to to IN cord-009571-mygj2nd4 1751 9 the the DT cord-009571-mygj2nd4 1751 10 inhibition inhibition NN cord-009571-mygj2nd4 1751 11 of of IN cord-009571-mygj2nd4 1751 12 EB EB NNP cord-009571-mygj2nd4 1751 13 binding bind VBG cord-009571-mygj2nd4 1751 14 to to IN cord-009571-mygj2nd4 1751 15 dsDNA dsdna RB cord-009571-mygj2nd4 1751 16 was be VBD cord-009571-mygj2nd4 1751 17 linear linear JJ cord-009571-mygj2nd4 1751 18 with with IN cord-009571-mygj2nd4 1751 19 in in IN cord-009571-mygj2nd4 1751 20 - - HYPH cord-009571-mygj2nd4 1751 21 creasing creasing NN cord-009571-mygj2nd4 1751 22 amounts amount NNS cord-009571-mygj2nd4 1751 23 of of IN cord-009571-mygj2nd4 1751 24 IgG igg NN cord-009571-mygj2nd4 1751 25 , , , cord-009571-mygj2nd4 1751 26 thus thus RB cord-009571-mygj2nd4 1751 27 allowing allow VBG cord-009571-mygj2nd4 1751 28 direct direct JJ cord-009571-mygj2nd4 1751 29 quantitation quantitation NN cord-009571-mygj2nd4 1751 30 of of IN cord-009571-mygj2nd4 1751 31 anti anti JJ cord-009571-mygj2nd4 1751 32 - - JJ cord-009571-mygj2nd4 1751 33 DNA dna JJ cord-009571-mygj2nd4 1751 34 activity activity NN cord-009571-mygj2nd4 1751 35 . . . cord-009571-mygj2nd4 1752 1 Since since IN cord-009571-mygj2nd4 1752 2 the the DT cord-009571-mygj2nd4 1752 3 binding binding JJ cord-009571-mygj2nd4 1752 4 constant constant NN cord-009571-mygj2nd4 1752 5 of of IN cord-009571-mygj2nd4 1752 6 EB EB NNP cord-009571-mygj2nd4 1752 7 is be VBZ cord-009571-mygj2nd4 1752 8 known know VBN cord-009571-mygj2nd4 1752 9 to to TO cord-009571-mygj2nd4 1752 10 be be VB cord-009571-mygj2nd4 1752 11 > > NFP cord-009571-mygj2nd4 1752 12 2 2 CD cord-009571-mygj2nd4 1752 13 X x NN cord-009571-mygj2nd4 1752 14 10-'M 10-'m CD cord-009571-mygj2nd4 1752 15 , , , cord-009571-mygj2nd4 1752 16 this this DT cord-009571-mygj2nd4 1752 17 assay assay NN cord-009571-mygj2nd4 1752 18 measures measure VBZ cord-009571-mygj2nd4 1752 19 high high JJ cord-009571-mygj2nd4 1752 20 avidity avidity NN cord-009571-mygj2nd4 1752 21 antibodies antibody NNS cord-009571-mygj2nd4 1752 22 and and CC cord-009571-mygj2nd4 1752 23 is be VBZ cord-009571-mygj2nd4 1752 24 not not RB cord-009571-mygj2nd4 1752 25 affected affect VBN cord-009571-mygj2nd4 1752 26 by by IN cord-009571-mygj2nd4 1752 27 non non JJ cord-009571-mygj2nd4 1752 28 - - JJ cord-009571-mygj2nd4 1752 29 specific specific JJ cord-009571-mygj2nd4 1752 30 , , , cord-009571-mygj2nd4 1752 31 low low JJ cord-009571-mygj2nd4 1752 32 - - HYPH cord-009571-mygj2nd4 1752 33 avidity avidity NN cord-009571-mygj2nd4 1752 34 D d NN cord-009571-mygj2nd4 1752 35 N n NN cord-009571-mygj2nd4 1752 36 A a DT cord-009571-mygj2nd4 1752 37 binding bind VBG cord-009571-mygj2nd4 1752 38 molecules molecule NNS cord-009571-mygj2nd4 1752 39 . . . cord-009571-mygj2nd4 1753 1 The the DT cord-009571-mygj2nd4 1753 2 specificity specificity NN cord-009571-mygj2nd4 1753 3 of of IN cord-009571-mygj2nd4 1753 4 anti anti JJ cord-009571-mygj2nd4 1753 5 - - JJ cord-009571-mygj2nd4 1753 6 DNA dna JJ cord-009571-mygj2nd4 1753 7 antibodies antibody NNS cord-009571-mygj2nd4 1753 8 in in IN cord-009571-mygj2nd4 1753 9 the the DT cord-009571-mygj2nd4 1753 10 EB EB NNP cord-009571-mygj2nd4 1753 11 assay assay NN cord-009571-mygj2nd4 1753 12 was be VBD cord-009571-mygj2nd4 1753 13 shown show VBN cord-009571-mygj2nd4 1753 14 when when WRB cord-009571-mygj2nd4 1753 15 absorption absorption NN cord-009571-mygj2nd4 1753 16 with with IN cord-009571-mygj2nd4 1753 17 excess excess JJ cord-009571-mygj2nd4 1753 18 nucleoside nucleoside NN cord-009571-mygj2nd4 1753 19 monophosphates monophosphate NNS cord-009571-mygj2nd4 1753 20 did do VBD cord-009571-mygj2nd4 1753 21 not not RB cord-009571-mygj2nd4 1753 22 alter alter VB cord-009571-mygj2nd4 1753 23 the the DT cord-009571-mygj2nd4 1753 24 inhibition inhibition NN cord-009571-mygj2nd4 1753 25 of of IN cord-009571-mygj2nd4 1753 26 EB EB NNP cord-009571-mygj2nd4 1753 27 binding bind VBG cord-009571-mygj2nd4 1753 28 in in IN cord-009571-mygj2nd4 1753 29 unabsorbed unabsorbed JJ cord-009571-mygj2nd4 1753 30 samples sample NNS cord-009571-mygj2nd4 1753 31 . . . cord-009571-mygj2nd4 1754 1 However however RB cord-009571-mygj2nd4 1754 2 , , , cord-009571-mygj2nd4 1754 3 the the DT cord-009571-mygj2nd4 1754 4 synthetic synthetic JJ cord-009571-mygj2nd4 1754 5 polynucleotides polynucleotides NNP cord-009571-mygj2nd4 1754 6 poly poly NNP cord-009571-mygj2nd4 1754 7 dA dA NNP cord-009571-mygj2nd4 1754 8 , , , cord-009571-mygj2nd4 1754 9 poly poly NNP cord-009571-mygj2nd4 1754 10 dT dT NNP cord-009571-mygj2nd4 1754 11 , , , cord-009571-mygj2nd4 1754 12 poly poly NNP cord-009571-mygj2nd4 1754 13 dC dC NNP cord-009571-mygj2nd4 1754 14 , , , cord-009571-mygj2nd4 1754 15 poly poly NNP cord-009571-mygj2nd4 1754 16 dA dA NNP cord-009571-mygj2nd4 1754 17 : : : cord-009571-mygj2nd4 1754 18 dT dT NNP cord-009571-mygj2nd4 1754 19 , , , cord-009571-mygj2nd4 1754 20 and and CC cord-009571-mygj2nd4 1754 21 poly poly NNP cord-009571-mygj2nd4 1754 22 dG dg NN cord-009571-mygj2nd4 1754 23 : : : cord-009571-mygj2nd4 1754 24 dC dC NNP cord-009571-mygj2nd4 1754 25 were be VBD cord-009571-mygj2nd4 1754 26 able able JJ cord-009571-mygj2nd4 1754 27 t t NN cord-009571-mygj2nd4 1754 28 o o UH cord-009571-mygj2nd4 1754 29 absorb absorb VB cord-009571-mygj2nd4 1754 30 DNA dna NN cord-009571-mygj2nd4 1754 31 binding binding NN cord-009571-mygj2nd4 1754 32 activity activity NN cord-009571-mygj2nd4 1754 33 . . . cord-009571-mygj2nd4 1755 1 Therefore therefore RB cord-009571-mygj2nd4 1755 2 , , , cord-009571-mygj2nd4 1755 3 the the DT cord-009571-mygj2nd4 1755 4 EB EB NNP cord-009571-mygj2nd4 1755 5 assay assay NN cord-009571-mygj2nd4 1755 6 has have VBZ cord-009571-mygj2nd4 1755 7 demonstrated demonstrate VBN cord-009571-mygj2nd4 1755 8 several several JJ cord-009571-mygj2nd4 1755 9 features feature NNS cord-009571-mygj2nd4 1755 10 which which WDT cord-009571-mygj2nd4 1755 11 make make VBP cord-009571-mygj2nd4 1755 12 it -PRON- PRP cord-009571-mygj2nd4 1755 13 an an DT cord-009571-mygj2nd4 1755 14 important important JJ cord-009571-mygj2nd4 1755 15 adjunct adjunct NN cord-009571-mygj2nd4 1755 16 in in IN cord-009571-mygj2nd4 1755 17 studying study VBG cord-009571-mygj2nd4 1755 18 the the DT cord-009571-mygj2nd4 1755 19 specificity specificity NN cord-009571-mygj2nd4 1755 20 and and CC cord-009571-mygj2nd4 1755 21 binding bind VBG cord-009571-mygj2nd4 1755 22 characteristics characteristic NNS cord-009571-mygj2nd4 1755 23 of of IN cord-009571-mygj2nd4 1755 24 anti anti JJ cord-009571-mygj2nd4 1755 25 - - JJ cord-009571-mygj2nd4 1755 26 DNA dna JJ cord-009571-mygj2nd4 1755 27 antibodies antibody NNS cord-009571-mygj2nd4 1755 28 . . . cord-009571-mygj2nd4 1756 1 In in IN cord-009571-mygj2nd4 1756 2 addition addition NN cord-009571-mygj2nd4 1756 3 , , , cord-009571-mygj2nd4 1756 4 the the DT cord-009571-mygj2nd4 1756 5 assay assay NN cord-009571-mygj2nd4 1756 6 is be VBZ cord-009571-mygj2nd4 1756 7 inexpensive inexpensive JJ cord-009571-mygj2nd4 1756 8 , , , cord-009571-mygj2nd4 1756 9 is be VBZ cord-009571-mygj2nd4 1756 10 easily easily RB cord-009571-mygj2nd4 1756 11 and and CC cord-009571-mygj2nd4 1756 12 quickly quickly RB cord-009571-mygj2nd4 1756 13 performed perform VBN cord-009571-mygj2nd4 1756 14 , , , cord-009571-mygj2nd4 1756 15 and and CC cord-009571-mygj2nd4 1756 16 it -PRON- PRP cord-009571-mygj2nd4 1756 17 does do VBZ cord-009571-mygj2nd4 1756 18 not not RB cord-009571-mygj2nd4 1756 19 require require VB cord-009571-mygj2nd4 1756 20 the the DT cord-009571-mygj2nd4 1756 21 use use NN cord-009571-mygj2nd4 1756 22 of of IN cord-009571-mygj2nd4 1756 23 radiolabeled radiolabele VBN cord-009571-mygj2nd4 1756 24 substrates substrate NNS cord-009571-mygj2nd4 1756 25 making make VBG cord-009571-mygj2nd4 1756 26 it -PRON- PRP cord-009571-mygj2nd4 1756 27 practical practical JJ cord-009571-mygj2nd4 1756 28 for for IN cord-009571-mygj2nd4 1756 29 further further JJ cord-009571-mygj2nd4 1756 30 development development NN cord-009571-mygj2nd4 1756 31 in in IN cord-009571-mygj2nd4 1756 32 investigative investigative JJ cord-009571-mygj2nd4 1756 33 and and CC cord-009571-mygj2nd4 1756 34 clinical clinical JJ cord-009571-mygj2nd4 1756 35 use use NN cord-009571-mygj2nd4 1756 36 . . . cord-009571-mygj2nd4 1757 1 Degradation degradation NN cord-009571-mygj2nd4 1757 2 of of IN cord-009571-mygj2nd4 1757 3 collagen collagen NN cord-009571-mygj2nd4 1757 4 in in IN cord-009571-mygj2nd4 1757 5 tendon tendon NN cord-009571-mygj2nd4 1757 6 , , , cord-009571-mygj2nd4 1757 7 bone bone NN cord-009571-mygj2nd4 1757 8 , , , cord-009571-mygj2nd4 1757 9 and and CC cord-009571-mygj2nd4 1757 10 cartilage cartilage NN cord-009571-mygj2nd4 1757 11 by by IN cord-009571-mygj2nd4 1757 12 collagenase collagenase NNP cord-009571-mygj2nd4 1757 13 is be VBZ cord-009571-mygj2nd4 1757 14 a a DT cord-009571-mygj2nd4 1757 15 significant significant JJ cord-009571-mygj2nd4 1757 16 factor factor NN cord-009571-mygj2nd4 1757 17 contributing contribute VBG cord-009571-mygj2nd4 1757 18 to to IN cord-009571-mygj2nd4 1757 19 the the DT cord-009571-mygj2nd4 1757 20 morbidity morbidity NN cord-009571-mygj2nd4 1757 21 of of IN cord-009571-mygj2nd4 1757 22 the the DT cord-009571-mygj2nd4 1757 23 inflammatory inflammatory JJ cord-009571-mygj2nd4 1757 24 arthritides arthritide NNS cord-009571-mygj2nd4 1757 25 . . . cord-009571-mygj2nd4 1758 1 Although although IN cord-009571-mygj2nd4 1758 2 considerable considerable JJ cord-009571-mygj2nd4 1758 3 information information NN cord-009571-mygj2nd4 1758 4 is be VBZ cord-009571-mygj2nd4 1758 5 available available JJ cord-009571-mygj2nd4 1758 6 as as IN cord-009571-mygj2nd4 1758 7 to to IN cord-009571-mygj2nd4 1758 8 the the DT cord-009571-mygj2nd4 1758 9 effect effect NN cord-009571-mygj2nd4 1758 10 of of IN cord-009571-mygj2nd4 1758 11 drugs drug NNS cord-009571-mygj2nd4 1758 12 and and CC cord-009571-mygj2nd4 1758 13 mediators mediator NNS cord-009571-mygj2nd4 1758 14 of of IN cord-009571-mygj2nd4 1758 15 inflammation inflammation NN cord-009571-mygj2nd4 1758 16 on on IN cord-009571-mygj2nd4 1758 17 collagenase collagenase JJ cord-009571-mygj2nd4 1758 18 production production NN cord-009571-mygj2nd4 1758 19 and and CC cord-009571-mygj2nd4 1758 20 activity activity NN cord-009571-mygj2nd4 1758 21 , , , cord-009571-mygj2nd4 1758 22 the the DT cord-009571-mygj2nd4 1758 23 mechanisms mechanism NNS cord-009571-mygj2nd4 1758 24 during during IN cord-009571-mygj2nd4 1758 25 aging age VBG cord-009571-mygj2nd4 1758 26 in in IN cord-009571-mygj2nd4 1758 27 the the DT cord-009571-mygj2nd4 1758 28 collagen collagen NN cord-009571-mygj2nd4 1758 29 fibril fibril NN cord-009571-mygj2nd4 1758 30 causing cause VBG cord-009571-mygj2nd4 1758 31 increased increase VBN cord-009571-mygj2nd4 1758 32 resistance resistance NN cord-009571-mygj2nd4 1758 33 to to IN cord-009571-mygj2nd4 1758 34 collagenase collagenase NNP cord-009571-mygj2nd4 1758 35 degradation degradation NN cord-009571-mygj2nd4 1758 36 are be VBP cord-009571-mygj2nd4 1758 37 poorly poorly RB cord-009571-mygj2nd4 1758 38 understood understand VBN cord-009571-mygj2nd4 1758 39 . . . cord-009571-mygj2nd4 1759 1 In in IN cord-009571-mygj2nd4 1759 2 this this DT cord-009571-mygj2nd4 1759 3 study study NN cord-009571-mygj2nd4 1759 4 , , , cord-009571-mygj2nd4 1759 5 the the DT cord-009571-mygj2nd4 1759 6 effect effect NN cord-009571-mygj2nd4 1759 7 of of IN cord-009571-mygj2nd4 1759 8 collagen collagen NN cord-009571-mygj2nd4 1759 9 cross cross NN cord-009571-mygj2nd4 1759 10 - - NN cord-009571-mygj2nd4 1759 11 linking link VBG cord-009571-mygj2nd4 1759 12 on on IN cord-009571-mygj2nd4 1759 13 collagenolysis collagenolysis NN cord-009571-mygj2nd4 1759 14 was be VBD cord-009571-mygj2nd4 1759 15 measured measure VBN cord-009571-mygj2nd4 1759 16 with with IN cord-009571-mygj2nd4 1759 17 an an DT cord-009571-mygj2nd4 1759 18 in in FW cord-009571-mygj2nd4 1759 19 vitro vitro FW cord-009571-mygj2nd4 1759 20 model model NN cord-009571-mygj2nd4 1759 21 system system NN cord-009571-mygj2nd4 1759 22 consisting consist VBG cord-009571-mygj2nd4 1759 23 of of IN cord-009571-mygj2nd4 1759 24 purified purify VBN cord-009571-mygj2nd4 1759 25 chick chick NN cord-009571-mygj2nd4 1759 26 calvarium calvarium NNP cord-009571-mygj2nd4 1759 27 collagen collagen NNP cord-009571-mygj2nd4 1759 28 fibrils fibril NNS cord-009571-mygj2nd4 1759 29 and and CC cord-009571-mygj2nd4 1759 30 lysyl lysyl JJ cord-009571-mygj2nd4 1759 31 oxidase oxidase NN cord-009571-mygj2nd4 1759 32 , , , cord-009571-mygj2nd4 1759 33 the the DT cord-009571-mygj2nd4 1759 34 cross cross NN cord-009571-mygj2nd4 1759 35 - - JJ cord-009571-mygj2nd4 1759 36 linking link VBG cord-009571-mygj2nd4 1759 37 enzyme enzyme NN cord-009571-mygj2nd4 1759 38 . . . cord-009571-mygj2nd4 1760 1 Chick Chick NNP cord-009571-mygj2nd4 1760 2 calvatia calvatia NN cord-009571-mygj2nd4 1760 3 collagen collagen NN cord-009571-mygj2nd4 1760 4 fibrils fibril NNS cord-009571-mygj2nd4 1760 5 were be VBD cord-009571-mygj2nd4 1760 6 cross cross NN cord-009571-mygj2nd4 1760 7 - - VBN cord-009571-mygj2nd4 1760 8 linked link VBN cord-009571-mygj2nd4 1760 9 by by IN cord-009571-mygj2nd4 1760 10 incubation incubation NN cord-009571-mygj2nd4 1760 11 with with IN cord-009571-mygj2nd4 1760 12 lysyl lysyl JJ cord-009571-mygj2nd4 1760 13 oxidase oxidase NN cord-009571-mygj2nd4 1760 14 for for IN cord-009571-mygj2nd4 1760 15 varying vary VBG cord-009571-mygj2nd4 1760 16 time time NN cord-009571-mygj2nd4 1760 17 . . . cord-009571-mygj2nd4 1761 1 Controls control NNS cord-009571-mygj2nd4 1761 2 consisted consist VBD cord-009571-mygj2nd4 1761 3 of of IN cord-009571-mygj2nd4 1761 4 collagen collagen NN cord-009571-mygj2nd4 1761 5 incubated incubate VBN cord-009571-mygj2nd4 1761 6 without without IN cord-009571-mygj2nd4 1761 7 enzyme enzyme NN cord-009571-mygj2nd4 1761 8 or or CC cord-009571-mygj2nd4 1761 9 with with IN cord-009571-mygj2nd4 1761 10 lysyl lysyl JJ cord-009571-mygj2nd4 1761 11 oxidase oxidase NN cord-009571-mygj2nd4 1761 12 plus plus CC cord-009571-mygj2nd4 1761 13 /3-aminopropionitrile /3-aminopropionitrile NNP cord-009571-mygj2nd4 1761 14 , , , cord-009571-mygj2nd4 1761 15 an an DT cord-009571-mygj2nd4 1761 16 irreversible irreversible JJ cord-009571-mygj2nd4 1761 17 inhibitor inhibitor NN cord-009571-mygj2nd4 1761 18 . . . cord-009571-mygj2nd4 1762 1 The the DT cord-009571-mygj2nd4 1762 2 fibrils fibril NNS cord-009571-mygj2nd4 1762 3 were be VBD cord-009571-mygj2nd4 1762 4 subsequently subsequently RB cord-009571-mygj2nd4 1762 5 measured measure VBN cord-009571-mygj2nd4 1762 6 for for IN cord-009571-mygj2nd4 1762 7 nascent nascent JJ cord-009571-mygj2nd4 1762 8 cross cross JJ cord-009571-mygj2nd4 1762 9 - - JJ cord-009571-mygj2nd4 1762 10 link link JJ cord-009571-mygj2nd4 1762 11 content content NN cord-009571-mygj2nd4 1762 12 or or CC cord-009571-mygj2nd4 1762 13 incubated incubate VBN cord-009571-mygj2nd4 1762 14 with with IN cord-009571-mygj2nd4 1762 15 purified purify VBN cord-009571-mygj2nd4 1762 16 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 1762 17 synovial synovial NN cord-009571-mygj2nd4 1762 18 collagenase collagenase NNP cord-009571-mygj2nd4 1762 19 , , , cord-009571-mygj2nd4 1762 20 and and CC cord-009571-mygj2nd4 1762 21 the the DT cord-009571-mygj2nd4 1762 22 rate rate NN cord-009571-mygj2nd4 1762 23 of of IN cord-009571-mygj2nd4 1762 24 collagenolysis collagenolysis NN cord-009571-mygj2nd4 1762 25 was be VBD cord-009571-mygj2nd4 1762 26 measured measure VBN cord-009571-mygj2nd4 1762 27 . . . cord-009571-mygj2nd4 1763 1 After after IN cord-009571-mygj2nd4 1763 2 synthesis synthesis NN cord-009571-mygj2nd4 1763 3 of of IN cord-009571-mygj2nd4 1763 4 approximately approximately RB cord-009571-mygj2nd4 1763 5 0.1 0.1 CD cord-009571-mygj2nd4 1763 6 Schiff Schiff NNP cord-009571-mygj2nd4 1763 7 base base NN cord-009571-mygj2nd4 1763 8 cross cross NN cord-009571-mygj2nd4 1763 9 - - NNS cord-009571-mygj2nd4 1763 10 links link NNS cord-009571-mygj2nd4 1763 11 per per IN cord-009571-mygj2nd4 1763 12 collagen collagen NN cord-009571-mygj2nd4 1763 13 molecule molecule NN cord-009571-mygj2nd4 1763 14 , , , cord-009571-mygj2nd4 1763 15 a a DT cord-009571-mygj2nd4 1763 16 ten ten CD cord-009571-mygj2nd4 1763 17 - - HYPH cord-009571-mygj2nd4 1763 18 fold fold JJ cord-009571-mygj2nd4 1763 19 resistance resistance NN cord-009571-mygj2nd4 1763 20 to to IN cord-009571-mygj2nd4 1763 21 collagenase collagenase NNP cord-009571-mygj2nd4 1763 22 digestion digestion NN cord-009571-mygj2nd4 1763 23 was be VBD cord-009571-mygj2nd4 1763 24 observed observe VBN cord-009571-mygj2nd4 1763 25 . . . cord-009571-mygj2nd4 1764 1 Inhibition inhibition NN cord-009571-mygj2nd4 1764 2 of of IN cord-009571-mygj2nd4 1764 3 collagenase collagenase NNP cord-009571-mygj2nd4 1764 4 by by IN cord-009571-mygj2nd4 1764 5 EDTA EDTA NNP cord-009571-mygj2nd4 1764 6 prevented prevent VBD cord-009571-mygj2nd4 1764 7 digestion digestion NN cord-009571-mygj2nd4 1764 8 . . . cord-009571-mygj2nd4 1765 1 Synthesis synthesis NN cord-009571-mygj2nd4 1765 2 of of IN cord-009571-mygj2nd4 1765 3 collagen collagen NN cord-009571-mygj2nd4 1765 4 fibrils fibril NNS cord-009571-mygj2nd4 1765 5 with with IN cord-009571-mygj2nd4 1765 6 higher high JJR cord-009571-mygj2nd4 1765 7 cross cross JJ cord-009571-mygj2nd4 1765 8 - - JJ cord-009571-mygj2nd4 1765 9 link link JJ cord-009571-mygj2nd4 1765 10 content content NN cord-009571-mygj2nd4 1765 11 resulted result VBD cord-009571-mygj2nd4 1765 12 in in IN cord-009571-mygj2nd4 1765 13 further further JJ cord-009571-mygj2nd4 1765 14 resistance resistance NN cord-009571-mygj2nd4 1765 15 . . . cord-009571-mygj2nd4 1766 1 These these DT cord-009571-mygj2nd4 1766 2 results result NNS cord-009571-mygj2nd4 1766 3 demonstrate demonstrate VBP cord-009571-mygj2nd4 1766 4 that that IN cord-009571-mygj2nd4 1766 5 the the DT cord-009571-mygj2nd4 1766 6 increased increase VBN cord-009571-mygj2nd4 1766 7 resistance resistance NN cord-009571-mygj2nd4 1766 8 of of IN cord-009571-mygj2nd4 1766 9 collagen collagen NN cord-009571-mygj2nd4 1766 10 to to IN cord-009571-mygj2nd4 1766 11 collagenolysis collagenolysis NN cord-009571-mygj2nd4 1766 12 observed observe VBN cord-009571-mygj2nd4 1766 13 during during IN cord-009571-mygj2nd4 1766 14 fibril fibril NNP cord-009571-mygj2nd4 1766 15 maturation maturation NN cord-009571-mygj2nd4 1766 16 in in IN cord-009571-mygj2nd4 1766 17 vivo vivo NN cord-009571-mygj2nd4 1766 18 is be VBZ cord-009571-mygj2nd4 1766 19 due due JJ cord-009571-mygj2nd4 1766 20 to to IN cord-009571-mygj2nd4 1766 21 synthesis synthesis NN cord-009571-mygj2nd4 1766 22 of of IN cord-009571-mygj2nd4 1766 23 native native JJ cord-009571-mygj2nd4 1766 24 , , , cord-009571-mygj2nd4 1766 25 unreduced unreduced JJ cord-009571-mygj2nd4 1766 26 Schiff Schiff NNP cord-009571-mygj2nd4 1766 27 base base NN cord-009571-mygj2nd4 1766 28 cross cross NN cord-009571-mygj2nd4 1766 29 - - NNS cord-009571-mygj2nd4 1766 30 links link NNS cord-009571-mygj2nd4 1766 31 . . . cord-009571-mygj2nd4 1767 1 The the DT cord-009571-mygj2nd4 1767 2 cross cross JJ cord-009571-mygj2nd4 1767 3 - - JJ cord-009571-mygj2nd4 1767 4 link link JJ cord-009571-mygj2nd4 1767 5 content content NN cord-009571-mygj2nd4 1767 6 at at IN cord-009571-mygj2nd4 1767 7 which which WDT cord-009571-mygj2nd4 1767 8 resistance resistance NN cord-009571-mygj2nd4 1767 9 to to IN cord-009571-mygj2nd4 1767 10 degradation degradation NN cord-009571-mygj2nd4 1767 11 develops develop VBZ cord-009571-mygj2nd4 1767 12 is be VBZ cord-009571-mygj2nd4 1767 13 significantly significantly RB cord-009571-mygj2nd4 1767 14 less less JJR cord-009571-mygj2nd4 1767 15 than than IN cord-009571-mygj2nd4 1767 16 that that DT cord-009571-mygj2nd4 1767 17 which which WDT cord-009571-mygj2nd4 1767 18 affects affect VBZ cord-009571-mygj2nd4 1767 19 fibril fibril NN cord-009571-mygj2nd4 1767 20 tensile tensile JJ cord-009571-mygj2nd4 1767 21 strength strength NN cord-009571-mygj2nd4 1767 22 in in IN cord-009571-mygj2nd4 1767 23 vivo vivo NNP cord-009571-mygj2nd4 1767 24 . . . cord-009571-mygj2nd4 1768 1 This this DT cord-009571-mygj2nd4 1768 2 suggests suggest VBZ cord-009571-mygj2nd4 1768 3 that that IN cord-009571-mygj2nd4 1768 4 resistance resistance NN cord-009571-mygj2nd4 1768 5 to to IN cord-009571-mygj2nd4 1768 6 collagenase collagenase NNP cord-009571-mygj2nd4 1768 7 is be VBZ cord-009571-mygj2nd4 1768 8 the the DT cord-009571-mygj2nd4 1768 9 earliest early JJS cord-009571-mygj2nd4 1768 10 physiological physiological JJ cord-009571-mygj2nd4 1768 11 effect effect NN cord-009571-mygj2nd4 1768 12 of of IN cord-009571-mygj2nd4 1768 13 cross cross NN cord-009571-mygj2nd4 1768 14 - - JJ cord-009571-mygj2nd4 1768 15 linking link VBG cord-009571-mygj2nd4 1768 16 in in IN cord-009571-mygj2nd4 1768 17 vivo vivo NN cord-009571-mygj2nd4 1768 18 . . . cord-009571-mygj2nd4 1769 1 The the DT cord-009571-mygj2nd4 1769 2 rate rate NN cord-009571-mygj2nd4 1769 3 of of IN cord-009571-mygj2nd4 1769 4 cross cross JJ cord-009571-mygj2nd4 1769 5 - - JJ cord-009571-mygj2nd4 1769 6 link link JJ cord-009571-mygj2nd4 1769 7 synthesis synthesis NN cord-009571-mygj2nd4 1769 8 may may MD cord-009571-mygj2nd4 1769 9 be be VB cord-009571-mygj2nd4 1769 10 a a DT cord-009571-mygj2nd4 1769 11 significant significant JJ cord-009571-mygj2nd4 1769 12 factor factor NN cord-009571-mygj2nd4 1769 13 regulating regulate VBG cord-009571-mygj2nd4 1769 14 the the DT cord-009571-mygj2nd4 1769 15 rate rate NN cord-009571-mygj2nd4 1769 16 of of IN cord-009571-mygj2nd4 1769 17 net net JJ cord-009571-mygj2nd4 1769 18 collagen collagen NN cord-009571-mygj2nd4 1769 19 deposition deposition NN cord-009571-mygj2nd4 1769 20 in in IN cord-009571-mygj2nd4 1769 21 normal normal JJ cord-009571-mygj2nd4 1769 22 and and CC cord-009571-mygj2nd4 1769 23 pathologic pathologic JJ cord-009571-mygj2nd4 1769 24 states state NNS cord-009571-mygj2nd4 1769 25 . . . cord-009571-mygj2nd4 1769 26 _SP cord-009571-mygj2nd4 1770 1 Vascular vascular JJ cord-009571-mygj2nd4 1770 2 abnormalities abnormality NNS cord-009571-mygj2nd4 1770 3 have have VBP cord-009571-mygj2nd4 1770 4 been be VBN cord-009571-mygj2nd4 1770 5 shown show VBN cord-009571-mygj2nd4 1770 6 to to TO cord-009571-mygj2nd4 1770 7 play play VB cord-009571-mygj2nd4 1770 8 an an DT cord-009571-mygj2nd4 1770 9 important important JJ cord-009571-mygj2nd4 1770 10 pathogenic pathogenic JJ cord-009571-mygj2nd4 1770 11 role role NN cord-009571-mygj2nd4 1770 12 in in IN cord-009571-mygj2nd4 1770 13 progressive progressive JJ cord-009571-mygj2nd4 1770 14 systemic systemic JJ cord-009571-mygj2nd4 1770 15 sclerosis sclerosis NN cord-009571-mygj2nd4 1770 16 ( ( -LRB- cord-009571-mygj2nd4 1770 17 PSS PSS NNP cord-009571-mygj2nd4 1770 18 ) ) -RRB- cord-009571-mygj2nd4 1770 19 , , , cord-009571-mygj2nd4 1770 20 especially especially RB cord-009571-mygj2nd4 1770 21 in in IN cord-009571-mygj2nd4 1770 22 the the DT cord-009571-mygj2nd4 1770 23 group group NN cord-009571-mygj2nd4 1770 24 of of IN cord-009571-mygj2nd4 1770 25 patients patient NNS cord-009571-mygj2nd4 1770 26 who who WP cord-009571-mygj2nd4 1770 27 develop develop VBP cord-009571-mygj2nd4 1770 28 rapidly rapidly RB cord-009571-mygj2nd4 1770 29 progressive progressive JJ cord-009571-mygj2nd4 1770 30 kidney kidney NN cord-009571-mygj2nd4 1770 31 disease disease NN cord-009571-mygj2nd4 1770 32 . . . cord-009571-mygj2nd4 1771 1 As as IN cord-009571-mygj2nd4 1771 2 part part NN cord-009571-mygj2nd4 1771 3 of of IN cord-009571-mygj2nd4 1771 4 a a DT cord-009571-mygj2nd4 1771 5 study study NN cord-009571-mygj2nd4 1771 6 of of IN cord-009571-mygj2nd4 1771 7 the the DT cord-009571-mygj2nd4 1771 8 kidney kidney NN cord-009571-mygj2nd4 1771 9 in in IN cord-009571-mygj2nd4 1771 10 PSS PSS NNP cord-009571-mygj2nd4 1771 11 , , , cord-009571-mygj2nd4 1771 12 we -PRON- PRP cord-009571-mygj2nd4 1771 13 have have VBP cord-009571-mygj2nd4 1771 14 also also RB cord-009571-mygj2nd4 1771 15 performed perform VBN cord-009571-mygj2nd4 1771 16 comprehensive comprehensive JJ cord-009571-mygj2nd4 1771 17 investigations investigation NNS cord-009571-mygj2nd4 1771 18 of of IN cord-009571-mygj2nd4 1771 19 coagulation coagulation NN cord-009571-mygj2nd4 1771 20 parameters parameter NNS cord-009571-mygj2nd4 1771 21 in in IN cord-009571-mygj2nd4 1771 22 order order NN cord-009571-mygj2nd4 1771 23 to to TO cord-009571-mygj2nd4 1771 24 evaluate evaluate VB cord-009571-mygj2nd4 1771 25 the the DT cord-009571-mygj2nd4 1771 26 possibilities possibility NNS cord-009571-mygj2nd4 1771 27 that that WDT cord-009571-mygj2nd4 1771 28 : : : cord-009571-mygj2nd4 1771 29 1 1 LS cord-009571-mygj2nd4 1771 30 ) ) -RRB- cord-009571-mygj2nd4 1771 31 coagulopathy coagulopathy NN cord-009571-mygj2nd4 1771 32 occurs occur VBZ cord-009571-mygj2nd4 1771 33 in in IN cord-009571-mygj2nd4 1771 34 these these DT cord-009571-mygj2nd4 1771 35 patients patient NNS cord-009571-mygj2nd4 1771 36 ; ; : cord-009571-mygj2nd4 1771 37 and and CC cord-009571-mygj2nd4 1771 38 2 2 LS cord-009571-mygj2nd4 1771 39 ) ) -RRB- cord-009571-mygj2nd4 1771 40 coagulation coagulation NN cord-009571-mygj2nd4 1771 41 abnormalities abnormality NNS cord-009571-mygj2nd4 1771 42 may may MD cord-009571-mygj2nd4 1771 43 be be VB cord-009571-mygj2nd4 1771 44 related relate VBN cord-009571-mygj2nd4 1771 45 to to IN cord-009571-mygj2nd4 1771 46 the the DT cord-009571-mygj2nd4 1771 47 development development NN cord-009571-mygj2nd4 1771 48 of of IN cord-009571-mygj2nd4 1771 49 renal renal JJ cord-009571-mygj2nd4 1771 50 disease disease NN cord-009571-mygj2nd4 1771 51 in in IN cord-009571-mygj2nd4 1771 52 PSS PSS NNP cord-009571-mygj2nd4 1771 53 . . . cord-009571-mygj2nd4 1772 1 Seven seven CD cord-009571-mygj2nd4 1772 2 patients patient NNS cord-009571-mygj2nd4 1772 3 with with IN cord-009571-mygj2nd4 1772 4 PSS PSS NNP cord-009571-mygj2nd4 1772 5 and and CC cord-009571-mygj2nd4 1772 6 normal normal JJ cord-009571-mygj2nd4 1772 7 renal renal JJ cord-009571-mygj2nd4 1772 8 function function NN cord-009571-mygj2nd4 1772 9 , , , cord-009571-mygj2nd4 1772 10 as as IN cord-009571-mygj2nd4 1772 11 judged judge VBN cord-009571-mygj2nd4 1772 12 by by IN cord-009571-mygj2nd4 1772 13 normal normal JJ cord-009571-mygj2nd4 1772 14 blood blood NN cord-009571-mygj2nd4 1772 15 pressure pressure NN cord-009571-mygj2nd4 1772 16 , , , cord-009571-mygj2nd4 1772 17 creatinine creatinine NN cord-009571-mygj2nd4 1772 18 clearance clearance NN cord-009571-mygj2nd4 1772 19 , , , cord-009571-mygj2nd4 1772 20 and and CC cord-009571-mygj2nd4 1772 21 absence absence NN cord-009571-mygj2nd4 1772 22 of of IN cord-009571-mygj2nd4 1772 23 proteinuria proteinuria NN cord-009571-mygj2nd4 1772 24 , , , cord-009571-mygj2nd4 1772 25 were be VBD cord-009571-mygj2nd4 1772 26 enrolled enrol VBN cord-009571-mygj2nd4 1772 27 in in IN cord-009571-mygj2nd4 1772 28 the the DT cord-009571-mygj2nd4 1772 29 study study NN cord-009571-mygj2nd4 1772 30 . . . cord-009571-mygj2nd4 1773 1 Coagulation coagulation NN cord-009571-mygj2nd4 1773 2 parameters parameter NNS cord-009571-mygj2nd4 1773 3 studied study VBD cord-009571-mygj2nd4 1773 4 included include VBD cord-009571-mygj2nd4 1773 5 prothrombin prothrombin NN cord-009571-mygj2nd4 1773 6 and and CC cord-009571-mygj2nd4 1773 7 partial partial JJ cord-009571-mygj2nd4 1773 8 thromboplastin thromboplastin NNP cord-009571-mygj2nd4 1773 9 times time NNS cord-009571-mygj2nd4 1773 10 , , , cord-009571-mygj2nd4 1773 11 fibrin fibrin NN cord-009571-mygj2nd4 1773 12 split split NN cord-009571-mygj2nd4 1773 13 products product NNS cord-009571-mygj2nd4 1773 14 , , , cord-009571-mygj2nd4 1773 15 fibrin fibrin NN cord-009571-mygj2nd4 1773 16 monomer monomer NN cord-009571-mygj2nd4 1773 17 , , , cord-009571-mygj2nd4 1773 18 Sonoclot@ Sonoclot@ NNP cord-009571-mygj2nd4 1773 19 ( ( -LRB- cord-009571-mygj2nd4 1773 20 which which WDT cord-009571-mygj2nd4 1773 21 reflects reflect VBZ cord-009571-mygj2nd4 1773 22 fibrin fibrin NN cord-009571-mygj2nd4 1773 23 monomer monomer NN cord-009571-mygj2nd4 1773 24 formation formation NN cord-009571-mygj2nd4 1773 25 in in IN cord-009571-mygj2nd4 1773 26 recalcified recalcifie VBN cord-009571-mygj2nd4 1773 27 whole whole JJ cord-009571-mygj2nd4 1773 28 blood blood NN cord-009571-mygj2nd4 1773 29 ) ) -RRB- cord-009571-mygj2nd4 1773 30 , , , cord-009571-mygj2nd4 1773 31 thromboelastograph thromboelastograph NNP cord-009571-mygj2nd4 1773 32 ( ( -LRB- cord-009571-mygj2nd4 1773 33 which which WDT cord-009571-mygj2nd4 1773 34 reflects reflect VBZ cord-009571-mygj2nd4 1773 35 fibrin fibrin NN cord-009571-mygj2nd4 1773 36 polymer polymer NN cord-009571-mygj2nd4 1773 37 formation formation NN cord-009571-mygj2nd4 1773 38 ) ) -RRB- cord-009571-mygj2nd4 1773 39 , , , cord-009571-mygj2nd4 1773 40 and and CC cord-009571-mygj2nd4 1773 41 platelet platelet NN cord-009571-mygj2nd4 1773 42 aggregometry aggregometry NN cord-009571-mygj2nd4 1773 43 . . . cord-009571-mygj2nd4 1774 1 In in IN cord-009571-mygj2nd4 1774 2 addition addition NN cord-009571-mygj2nd4 1774 3 , , , cord-009571-mygj2nd4 1774 4 each each DT cord-009571-mygj2nd4 1774 5 patient patient NN cord-009571-mygj2nd4 1774 6 underwent undergo VBD cord-009571-mygj2nd4 1774 7 percutaneous percutaneous JJ cord-009571-mygj2nd4 1774 8 renal renal JJ cord-009571-mygj2nd4 1774 9 biopsy biopsy NN cord-009571-mygj2nd4 1774 10 . . . cord-009571-mygj2nd4 1775 1 Patients patient NNS cord-009571-mygj2nd4 1775 2 with with IN cord-009571-mygj2nd4 1775 3 PSS PSS NNP cord-009571-mygj2nd4 1775 4 showed show VBD cord-009571-mygj2nd4 1775 5 platelet platelet NN cord-009571-mygj2nd4 1775 6 hyperreactivity hyperreactivity NN cord-009571-mygj2nd4 1775 7 t t NN cord-009571-mygj2nd4 1775 8 o o NN cord-009571-mygj2nd4 1775 9 collagen collagen NN cord-009571-mygj2nd4 1775 10 but but CC cord-009571-mygj2nd4 1775 11 not not RB cord-009571-mygj2nd4 1775 12 to to IN cord-009571-mygj2nd4 1775 13 other other JJ cord-009571-mygj2nd4 1775 14 agents agent NNS cord-009571-mygj2nd4 1775 15 ( ( -LRB- cord-009571-mygj2nd4 1775 16 91 91 CD cord-009571-mygj2nd4 1775 17 % % NN cord-009571-mygj2nd4 1775 18 aggregation aggregation NN cord-009571-mygj2nd4 1775 19 versus versus IN cord-009571-mygj2nd4 1775 20 control control NN cord-009571-mygj2nd4 1775 21 of of IN cord-009571-mygj2nd4 1775 22 80.6 80.6 CD cord-009571-mygj2nd4 1775 23 % % NN cord-009571-mygj2nd4 1775 24 P p NN cord-009571-mygj2nd4 1775 25 < < XX cord-009571-mygj2nd4 1775 26 0.01 0.01 CD cord-009571-mygj2nd4 1775 27 ) ) -RRB- cord-009571-mygj2nd4 1775 28 . . . cord-009571-mygj2nd4 1776 1 The the DT cord-009571-mygj2nd4 1776 2 following follow VBG cord-009571-mygj2nd4 1776 3 abnormalities abnormality NNS cord-009571-mygj2nd4 1776 4 , , , cord-009571-mygj2nd4 1776 5 indicative indicative JJ cord-009571-mygj2nd4 1776 6 of of IN cord-009571-mygj2nd4 1776 7 a a DT cord-009571-mygj2nd4 1776 8 hypercoagulable hypercoagulable JJ cord-009571-mygj2nd4 1776 9 state state NN cord-009571-mygj2nd4 1776 10 , , , cord-009571-mygj2nd4 1776 11 were be VBD cord-009571-mygj2nd4 1776 12 found find VBN cord-009571-mygj2nd4 1776 13 : : : cord-009571-mygj2nd4 1776 14 increased increase VBN cord-009571-mygj2nd4 1776 15 rate rate NN cord-009571-mygj2nd4 1776 16 of of IN cord-009571-mygj2nd4 1776 17 clotting clotting NN cord-009571-mygj2nd4 1776 18 by by IN cord-009571-mygj2nd4 1776 19 thromboelastograph thromboelastograph NNP cord-009571-mygj2nd4 1776 20 in in IN cord-009571-mygj2nd4 1776 21 5 5 CD cord-009571-mygj2nd4 1776 22 patients patient NNS cord-009571-mygj2nd4 1776 23 ; ; , cord-009571-mygj2nd4 1776 24 increased increase VBN cord-009571-mygj2nd4 1776 25 rate rate NN cord-009571-mygj2nd4 1776 26 of of IN cord-009571-mygj2nd4 1776 27 clotting clotting NN cord-009571-mygj2nd4 1776 28 by by IN cord-009571-mygj2nd4 1776 29 Sonoclot Sonoclot NNP cord-009571-mygj2nd4 1776 30 in in IN cord-009571-mygj2nd4 1776 31 4 4 CD cord-009571-mygj2nd4 1776 32 patients patient NNS cord-009571-mygj2nd4 1776 33 ; ; : cord-009571-mygj2nd4 1776 34 and and CC cord-009571-mygj2nd4 1776 35 premature premature JJ cord-009571-mygj2nd4 1776 36 onset onset NN cord-009571-mygj2nd4 1776 37 of of IN cord-009571-mygj2nd4 1776 38 clotting clotting NN cord-009571-mygj2nd4 1776 39 by by IN cord-009571-mygj2nd4 1776 40 thromboelastograph thromboelastograph NNP cord-009571-mygj2nd4 1776 41 in in IN cord-009571-mygj2nd4 1776 42 3 3 CD cord-009571-mygj2nd4 1776 43 patients patient NNS cord-009571-mygj2nd4 1776 44 . . . cord-009571-mygj2nd4 1777 1 The the DT cord-009571-mygj2nd4 1777 2 patient patient NN cord-009571-mygj2nd4 1777 3 with with IN cord-009571-mygj2nd4 1777 4 the the DT cord-009571-mygj2nd4 1777 5 most most RBS cord-009571-mygj2nd4 1777 6 hypercoagulable hypercoagulable JJ cord-009571-mygj2nd4 1777 7 profile profile NN cord-009571-mygj2nd4 1777 8 has have VBZ cord-009571-mygj2nd4 1777 9 subsequently subsequently RB cord-009571-mygj2nd4 1777 10 developed develop VBN cord-009571-mygj2nd4 1777 11 mild mild JJ cord-009571-mygj2nd4 1777 12 proteinuria proteinuria NN cord-009571-mygj2nd4 1777 13 . . . cord-009571-mygj2nd4 1778 1 Five five CD cord-009571-mygj2nd4 1778 2 patients patient NNS cord-009571-mygj2nd4 1778 3 had have VBD cord-009571-mygj2nd4 1778 4 renal renal JJ cord-009571-mygj2nd4 1778 5 biopsy biopsy NN cord-009571-mygj2nd4 1778 6 findings finding NNS cord-009571-mygj2nd4 1778 7 on on IN cord-009571-mygj2nd4 1778 8 light light JJ cord-009571-mygj2nd4 1778 9 microscopy microscopy NNS cord-009571-mygj2nd4 1778 10 suggestive suggestive JJ cord-009571-mygj2nd4 1778 11 of of IN cord-009571-mygj2nd4 1778 12 PSS PSS NNP cord-009571-mygj2nd4 1778 13 kidney kidney NN cord-009571-mygj2nd4 1778 14 disease disease NN cord-009571-mygj2nd4 1778 15 , , , cord-009571-mygj2nd4 1778 16 including include VBG cord-009571-mygj2nd4 1778 17 vascular vascular JJ cord-009571-mygj2nd4 1778 18 intimal intimal JJ cord-009571-mygj2nd4 1778 19 fibrosis fibrosis NN cord-009571-mygj2nd4 1778 20 , , , cord-009571-mygj2nd4 1778 21 sclerosis sclerosis NN cord-009571-mygj2nd4 1778 22 , , , cord-009571-mygj2nd4 1778 23 and and CC cord-009571-mygj2nd4 1778 24 fibrinoid fibrinoid JJ cord-009571-mygj2nd4 1778 25 necrosis necrosis NN cord-009571-mygj2nd4 1778 26 . . . cord-009571-mygj2nd4 1779 1 Four four CD cord-009571-mygj2nd4 1779 2 of of IN cord-009571-mygj2nd4 1779 3 these these DT cord-009571-mygj2nd4 1779 4 5 5 CD cord-009571-mygj2nd4 1779 5 were be VBD cord-009571-mygj2nd4 1779 6 hypercoagulable hypercoagulable JJ cord-009571-mygj2nd4 1779 7 by by IN cord-009571-mygj2nd4 1779 8 one one CD cord-009571-mygj2nd4 1779 9 or or CC cord-009571-mygj2nd4 1779 10 more more JJR cord-009571-mygj2nd4 1779 11 tests test NNS cord-009571-mygj2nd4 1779 12 ; ; : cord-009571-mygj2nd4 1779 13 both both DT cord-009571-mygj2nd4 1779 14 patients patient NNS cord-009571-mygj2nd4 1779 15 with with IN cord-009571-mygj2nd4 1779 16 normal normal JJ cord-009571-mygj2nd4 1779 17 biopsies biopsy NNS cord-009571-mygj2nd4 1779 18 had have VBD cord-009571-mygj2nd4 1779 19 normal normal JJ cord-009571-mygj2nd4 1779 20 coagulation coagulation NN cord-009571-mygj2nd4 1779 21 profiles profile NNS cord-009571-mygj2nd4 1779 22 . . . cord-009571-mygj2nd4 1780 1 These these DT cord-009571-mygj2nd4 1780 2 data datum NNS cord-009571-mygj2nd4 1780 3 suggest suggest VBP cord-009571-mygj2nd4 1780 4 that that IN cord-009571-mygj2nd4 1780 5 : : : cord-009571-mygj2nd4 1780 6 1 1 LS cord-009571-mygj2nd4 1780 7 ) ) -RRB- cord-009571-mygj2nd4 1780 8 platelet platelet NN cord-009571-mygj2nd4 1780 9 - - HYPH cord-009571-mygj2nd4 1780 10 collagen collagen NN cord-009571-mygj2nd4 1780 11 interactions interaction NNS cord-009571-mygj2nd4 1780 12 may may MD cord-009571-mygj2nd4 1780 13 be be VB cord-009571-mygj2nd4 1780 14 abnormal abnormal JJ cord-009571-mygj2nd4 1780 15 in in IN cord-009571-mygj2nd4 1780 16 PSS PSS NNP cord-009571-mygj2nd4 1780 17 ; ; : cord-009571-mygj2nd4 1780 18 2 2 LS cord-009571-mygj2nd4 1780 19 ) ) -RRB- cord-009571-mygj2nd4 1780 20 certain certain JJ cord-009571-mygj2nd4 1780 21 patients patient NNS cord-009571-mygj2nd4 1780 22 with with IN cord-009571-mygj2nd4 1780 23 PSS PSS NNP cord-009571-mygj2nd4 1780 24 manifest manifest VB cord-009571-mygj2nd4 1780 25 laboratory laboratory NN cord-009571-mygj2nd4 1780 26 evidence evidence NN cord-009571-mygj2nd4 1780 27 of of IN cord-009571-mygj2nd4 1780 28 hypercoagulability hypercoagulability NN cord-009571-mygj2nd4 1780 29 ; ; : cord-009571-mygj2nd4 1780 30 and and CC cord-009571-mygj2nd4 1780 31 3 3 LS cord-009571-mygj2nd4 1780 32 ) ) -RRB- cord-009571-mygj2nd4 1780 33 hypercoagulability hypercoagulability NN cord-009571-mygj2nd4 1780 34 appears appear VBZ cord-009571-mygj2nd4 1780 35 to to TO cord-009571-mygj2nd4 1780 36 correlate correlate VB cord-009571-mygj2nd4 1780 37 with with IN cord-009571-mygj2nd4 1780 38 renal renal JJ cord-009571-mygj2nd4 1780 39 biopsy biopsy NN cord-009571-mygj2nd4 1780 40 abnormalities abnormality NNS cord-009571-mygj2nd4 1780 41 in in IN cord-009571-mygj2nd4 1780 42 PSS PSS NNP cord-009571-mygj2nd4 1780 43 patients patient NNS cord-009571-mygj2nd4 1780 44 with with IN cord-009571-mygj2nd4 1780 45 normal normal JJ cord-009571-mygj2nd4 1780 46 renal renal JJ cord-009571-mygj2nd4 1780 47 function function NN cord-009571-mygj2nd4 1780 48 . . . cord-009571-mygj2nd4 1781 1 Normal normal JJ cord-009571-mygj2nd4 1781 2 human human JJ cord-009571-mygj2nd4 1781 3 mononuclear mononuclear NN cord-009571-mygj2nd4 1781 4 cells cell NNS cord-009571-mygj2nd4 1781 5 spontaneously spontaneously RB cord-009571-mygj2nd4 1781 6 lyse lyse VBP cord-009571-mygj2nd4 1781 7 in in FW cord-009571-mygj2nd4 1781 8 vitro vitro FW cord-009571-mygj2nd4 1781 9 targets target NNS cord-009571-mygj2nd4 1781 10 derived derive VBN cord-009571-mygj2nd4 1781 11 from from IN cord-009571-mygj2nd4 1781 12 cell cell NN cord-009571-mygj2nd4 1781 13 lines line NNS cord-009571-mygj2nd4 1781 14 of of IN cord-009571-mygj2nd4 1781 15 tumor tumor NN cord-009571-mygj2nd4 1781 16 origin origin NN cord-009571-mygj2nd4 1781 17 . . . cord-009571-mygj2nd4 1782 1 The the DT cord-009571-mygj2nd4 1782 2 natural natural JJ cord-009571-mygj2nd4 1782 3 killing killing NN cord-009571-mygj2nd4 1782 4 of of IN cord-009571-mygj2nd4 1782 5 K-562 k-562 NN cord-009571-mygj2nd4 1782 6 , , , cord-009571-mygj2nd4 1782 7 a a DT cord-009571-mygj2nd4 1782 8 tumor tumor NN cord-009571-mygj2nd4 1782 9 cell cell NN cord-009571-mygj2nd4 1782 10 line line NN cord-009571-mygj2nd4 1782 11 derived derive VBN cord-009571-mygj2nd4 1782 12 from from IN cord-009571-mygj2nd4 1782 13 a a DT cord-009571-mygj2nd4 1782 14 patient patient NN cord-009571-mygj2nd4 1782 15 with with IN cord-009571-mygj2nd4 1782 16 chronic chronic JJ cord-009571-mygj2nd4 1782 17 myelogenous myelogenous NN cord-009571-mygj2nd4 1782 18 leukemia leukemia NN cord-009571-mygj2nd4 1782 19 , , , cord-009571-mygj2nd4 1782 20 varies vary VBZ cord-009571-mygj2nd4 1782 21 in in IN cord-009571-mygj2nd4 1782 22 patients patient NNS cord-009571-mygj2nd4 1782 23 with with IN cord-009571-mygj2nd4 1782 24 systemic systemic JJ cord-009571-mygj2nd4 1782 25 lupus lupus NN cord-009571-mygj2nd4 1782 26 erythematosus erythematosus NN cord-009571-mygj2nd4 1782 27 ( ( -LRB- cord-009571-mygj2nd4 1782 28 SLE SLE NNP cord-009571-mygj2nd4 1782 29 ) ) -RRB- cord-009571-mygj2nd4 1782 30 ( ( -LRB- cord-009571-mygj2nd4 1782 31 27 27 CD cord-009571-mygj2nd4 1782 32 % % NN cord-009571-mygj2nd4 1782 33 f f NNP cord-009571-mygj2nd4 1782 34 21 21 CD cord-009571-mygj2nd4 1782 35 % % NN cord-009571-mygj2nd4 1782 36 ) ) -RRB- cord-009571-mygj2nd4 1782 37 and and CC cord-009571-mygj2nd4 1782 38 controls control NNS cord-009571-mygj2nd4 1782 39 ( ( -LRB- cord-009571-mygj2nd4 1782 40 35 35 CD cord-009571-mygj2nd4 1782 41 % % NN cord-009571-mygj2nd4 1782 42 f f NN cord-009571-mygj2nd4 1782 43 20 20 CD cord-009571-mygj2nd4 1782 44 % % NN cord-009571-mygj2nd4 1782 45 ) ) -RRB- cord-009571-mygj2nd4 1782 46 . . . cord-009571-mygj2nd4 1783 1 T T NNP cord-009571-mygj2nd4 1783 2 o o NN cord-009571-mygj2nd4 1783 3 evaluate evaluate VBP cord-009571-mygj2nd4 1783 4 the the DT cord-009571-mygj2nd4 1783 5 possible possible JJ cord-009571-mygj2nd4 1783 6 role role NN cord-009571-mygj2nd4 1783 7 of of IN cord-009571-mygj2nd4 1783 8 serum serum NN cord-009571-mygj2nd4 1783 9 factors factor NNS cord-009571-mygj2nd4 1783 10 , , , cord-009571-mygj2nd4 1783 11 normal normal JJ cord-009571-mygj2nd4 1783 12 peripheral peripheral JJ cord-009571-mygj2nd4 1783 13 blood blood NN cord-009571-mygj2nd4 1783 14 mononuclear mononuclear NN cord-009571-mygj2nd4 1783 15 cells cell NNS cord-009571-mygj2nd4 1783 16 were be VBD cord-009571-mygj2nd4 1783 17 incubated incubate VBN cord-009571-mygj2nd4 1783 18 with with IN cord-009571-mygj2nd4 1783 19 12 12 CD cord-009571-mygj2nd4 1783 20 SLE SLE NNP cord-009571-mygj2nd4 1783 21 sera sera NNP cord-009571-mygj2nd4 1783 22 , , , cord-009571-mygj2nd4 1783 23 10 10 CD cord-009571-mygj2nd4 1783 24 normal normal JJ cord-009571-mygj2nd4 1783 25 control control NN cord-009571-mygj2nd4 1783 26 sera sera NNP cord-009571-mygj2nd4 1783 27 , , , cord-009571-mygj2nd4 1783 28 or or CC cord-009571-mygj2nd4 1783 29 media medium NNS cord-009571-mygj2nd4 1783 30 alone alone JJ cord-009571-mygj2nd4 1783 31 in in IN cord-009571-mygj2nd4 1783 32 the the DT cord-009571-mygj2nd4 1783 33 natural natural JJ cord-009571-mygj2nd4 1783 34 killing killing NN cord-009571-mygj2nd4 1783 35 assay assay NN cord-009571-mygj2nd4 1783 36 . . . cord-009571-mygj2nd4 1784 1 0.5 0.5 CD cord-009571-mygj2nd4 1784 2 X x NN cord-009571-mygj2nd4 1784 3 l(P l(P NNP cord-009571-mygj2nd4 1784 4 Ficoll Ficoll NNP cord-009571-mygj2nd4 1784 5 - - HYPH cord-009571-mygj2nd4 1784 6 Hypaque hypaque JJ cord-009571-mygj2nd4 1784 7 purified purify VBN cord-009571-mygj2nd4 1784 8 mononuclear mononuclear NN cord-009571-mygj2nd4 1784 9 cells cell NNS cord-009571-mygj2nd4 1784 10 after after IN cord-009571-mygj2nd4 1784 11 pretreatment pretreatment NN cord-009571-mygj2nd4 1784 12 with with IN cord-009571-mygj2nd4 1784 13 sera sera NNP cord-009571-mygj2nd4 1784 14 or or CC cord-009571-mygj2nd4 1784 15 media medium NNS cord-009571-mygj2nd4 1784 16 were be VBD cord-009571-mygj2nd4 1784 17 incubated incubate VBN cord-009571-mygj2nd4 1784 18 for for IN cord-009571-mygj2nd4 1784 19 4 4 CD cord-009571-mygj2nd4 1784 20 hours hour NNS cord-009571-mygj2nd4 1784 21 with with IN cord-009571-mygj2nd4 1784 22 1 1 CD cord-009571-mygj2nd4 1784 23 X x NN cord-009571-mygj2nd4 1784 24 10 10 CD cord-009571-mygj2nd4 1784 25 ' ' `` cord-009571-mygj2nd4 1784 26 S1chromium s1chromium NN cord-009571-mygj2nd4 1784 27 ( ( -LRB- cord-009571-mygj2nd4 1784 28 " " `` cord-009571-mygj2nd4 1784 29 Cr Cr NNP cord-009571-mygj2nd4 1784 30 ) ) -RRB- cord-009571-mygj2nd4 1784 31 labeled label VBN cord-009571-mygj2nd4 1784 32 K-562 k-562 IN cord-009571-mygj2nd4 1784 33 cells cell NNS cord-009571-mygj2nd4 1784 34 . . . cord-009571-mygj2nd4 1785 1 Cytotoxicity Cytotoxicity NNP cord-009571-mygj2nd4 1785 2 was be VBD cord-009571-mygj2nd4 1785 3 measured measure VBN cord-009571-mygj2nd4 1785 4 by by IN cord-009571-mygj2nd4 1785 5 the the DT cord-009571-mygj2nd4 1785 6 release release NN cord-009571-mygj2nd4 1785 7 of of IN cord-009571-mygj2nd4 1785 8 into into IN cord-009571-mygj2nd4 1785 9 the the DT cord-009571-mygj2nd4 1785 10 supernatant supernatant NN cord-009571-mygj2nd4 1785 11 . . . cord-009571-mygj2nd4 1786 1 The the DT cord-009571-mygj2nd4 1786 2 mean mean JJ cord-009571-mygj2nd4 1786 3 61Cr 61cr CD cord-009571-mygj2nd4 1786 4 release release NN cord-009571-mygj2nd4 1786 5 in in IN cord-009571-mygj2nd4 1786 6 the the DT cord-009571-mygj2nd4 1786 7 presence presence NN cord-009571-mygj2nd4 1786 8 of of IN cord-009571-mygj2nd4 1786 9 normal normal JJ cord-009571-mygj2nd4 1786 10 human human JJ cord-009571-mygj2nd4 1786 11 sera sera NNP cord-009571-mygj2nd4 1786 12 was be VBD cord-009571-mygj2nd4 1786 13 96 96 CD cord-009571-mygj2nd4 1786 14 % % NN cord-009571-mygj2nd4 1786 15 f f NN cord-009571-mygj2nd4 1786 16 4 4 CD cord-009571-mygj2nd4 1786 17 % % NN cord-009571-mygj2nd4 1786 18 of of IN cord-009571-mygj2nd4 1786 19 that that DT cord-009571-mygj2nd4 1786 20 with with IN cord-009571-mygj2nd4 1786 21 media medium NNS cord-009571-mygj2nd4 1786 22 alone alone RB cord-009571-mygj2nd4 1786 23 . . . cord-009571-mygj2nd4 1787 1 In in IN cord-009571-mygj2nd4 1787 2 the the DT cord-009571-mygj2nd4 1787 3 presence presence NN cord-009571-mygj2nd4 1787 4 of of IN cord-009571-mygj2nd4 1787 5 SLE SLE NNP cord-009571-mygj2nd4 1787 6 sera sera NNP cord-009571-mygj2nd4 1787 7 , , , cord-009571-mygj2nd4 1787 8 mean mean VB cord-009571-mygj2nd4 1787 9 61Cr 61cr CD cord-009571-mygj2nd4 1787 10 release release NN cord-009571-mygj2nd4 1787 11 was be VBD cord-009571-mygj2nd4 1787 12 36 36 CD cord-009571-mygj2nd4 1787 13 % % NN cord-009571-mygj2nd4 1787 14 & & CC cord-009571-mygj2nd4 1787 15 24 24 CD cord-009571-mygj2nd4 1787 16 % % NN cord-009571-mygj2nd4 1787 17 of of IN cord-009571-mygj2nd4 1787 18 that that DT cord-009571-mygj2nd4 1787 19 with with IN cord-009571-mygj2nd4 1787 20 media medium NNS cord-009571-mygj2nd4 1787 21 alone alone RB cord-009571-mygj2nd4 1787 22 . . . cord-009571-mygj2nd4 1788 1 The the DT cord-009571-mygj2nd4 1788 2 magnitude magnitude NN cord-009571-mygj2nd4 1788 3 of of IN cord-009571-mygj2nd4 1788 4 natural natural JJ cord-009571-mygj2nd4 1788 5 killing killing NN cord-009571-mygj2nd4 1788 6 suppression suppression NN cord-009571-mygj2nd4 1788 7 by by IN cord-009571-mygj2nd4 1788 8 SLE SLE NNP cord-009571-mygj2nd4 1788 9 sera sera NNP cord-009571-mygj2nd4 1788 10 did do VBD cord-009571-mygj2nd4 1788 11 not not RB cord-009571-mygj2nd4 1788 12 correlate correlate VB cord-009571-mygj2nd4 1788 13 with with IN cord-009571-mygj2nd4 1788 14 complement complement JJ cord-009571-mygj2nd4 1788 15 levels level NNS cord-009571-mygj2nd4 1788 16 , , , cord-009571-mygj2nd4 1788 17 ANA ANA NNP cord-009571-mygj2nd4 1788 18 titer titer NN cord-009571-mygj2nd4 1788 19 , , , cord-009571-mygj2nd4 1788 20 or or CC cord-009571-mygj2nd4 1788 21 D D NNP cord-009571-mygj2nd4 1788 22 N N NNP cord-009571-mygj2nd4 1788 23 A A NNP cord-009571-mygj2nd4 1788 24 binding binding NN cord-009571-mygj2nd4 1788 25 . . . cord-009571-mygj2nd4 1789 1 The the DT cord-009571-mygj2nd4 1789 2 natural natural JJ cord-009571-mygj2nd4 1789 3 killing killing NN cord-009571-mygj2nd4 1789 4 suppression suppression NN cord-009571-mygj2nd4 1789 5 by by IN cord-009571-mygj2nd4 1789 6 an an DT cord-009571-mygj2nd4 1789 7 individual individual JJ cord-009571-mygj2nd4 1789 8 SLE SLE NNP cord-009571-mygj2nd4 1789 9 serum serum NN cord-009571-mygj2nd4 1789 10 did do VBD cord-009571-mygj2nd4 1789 11 not not RB cord-009571-mygj2nd4 1789 12 correlate correlate VB cord-009571-mygj2nd4 1789 13 with with IN cord-009571-mygj2nd4 1789 14 its -PRON- PRP$ cord-009571-mygj2nd4 1789 15 inhibition inhibition NN cord-009571-mygj2nd4 1789 16 of of IN cord-009571-mygj2nd4 1789 17 the the DT cord-009571-mygj2nd4 1789 18 antibody antibody NN cord-009571-mygj2nd4 1789 19 dependent dependent JJ cord-009571-mygj2nd4 1789 20 cell cell NN cord-009571-mygj2nd4 1789 21 mediated mediate VBD cord-009571-mygj2nd4 1789 22 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 1789 23 of of IN cord-009571-mygj2nd4 1789 24 chicken chicken NN cord-009571-mygj2nd4 1789 25 red red JJ cord-009571-mygj2nd4 1789 26 cells cell NNS cord-009571-mygj2nd4 1789 27 . . . cord-009571-mygj2nd4 1790 1 The the DT cord-009571-mygj2nd4 1790 2 factors factor NNS cord-009571-mygj2nd4 1790 3 in in IN cord-009571-mygj2nd4 1790 4 SLE SLE NNP cord-009571-mygj2nd4 1790 5 sera sera NNP cord-009571-mygj2nd4 1790 6 responsible responsible JJ cord-009571-mygj2nd4 1790 7 for for IN cord-009571-mygj2nd4 1790 8 suppression suppression NN cord-009571-mygj2nd4 1790 9 of of IN cord-009571-mygj2nd4 1790 10 natural natural JJ cord-009571-mygj2nd4 1790 11 killings killing NNS cord-009571-mygj2nd4 1790 12 are be VBP cord-009571-mygj2nd4 1790 13 non non JJ cord-009571-mygj2nd4 1790 14 - - JJ cord-009571-mygj2nd4 1790 15 dialyzable dialyzable JJ cord-009571-mygj2nd4 1790 16 , , , cord-009571-mygj2nd4 1790 17 precipitable precipitable JJ cord-009571-mygj2nd4 1790 18 with with IN cord-009571-mygj2nd4 1790 19 50 50 CD cord-009571-mygj2nd4 1790 20 % % NN cord-009571-mygj2nd4 1790 21 ( ( -LRB- cord-009571-mygj2nd4 1790 22 NH,),SO NH,),SO NNP cord-009571-mygj2nd4 1790 23 , , , cord-009571-mygj2nd4 1790 24 , , , cord-009571-mygj2nd4 1790 25 and and CC cord-009571-mygj2nd4 1790 26 removable removable JJ cord-009571-mygj2nd4 1790 27 by by IN cord-009571-mygj2nd4 1790 28 absorption absorption NN cord-009571-mygj2nd4 1790 29 with with IN cord-009571-mygj2nd4 1790 30 anti anti JJ cord-009571-mygj2nd4 1790 31 - - JJ cord-009571-mygj2nd4 1790 32 Ig ig JJ cord-009571-mygj2nd4 1790 33 antibody antibody NN cord-009571-mygj2nd4 1790 34 . . . cord-009571-mygj2nd4 1791 1 The the DT cord-009571-mygj2nd4 1791 2 factors factor NNS cord-009571-mygj2nd4 1791 3 are be VBP cord-009571-mygj2nd4 1791 4 excluded exclude VBN cord-009571-mygj2nd4 1791 5 by by IN cord-009571-mygj2nd4 1791 6 a a DT cord-009571-mygj2nd4 1791 7 G-200 g-200 JJ cord-009571-mygj2nd4 1791 8 column column NN cord-009571-mygj2nd4 1791 9 . . . cord-009571-mygj2nd4 1792 1 The the DT cord-009571-mygj2nd4 1792 2 major major JJ cord-009571-mygj2nd4 1792 3 portion portion NN cord-009571-mygj2nd4 1792 4 of of IN cord-009571-mygj2nd4 1792 5 the the DT cord-009571-mygj2nd4 1792 6 suppressive suppressive JJ cord-009571-mygj2nd4 1792 7 activity activity NN cord-009571-mygj2nd4 1792 8 was be VBD cord-009571-mygj2nd4 1792 9 found find VBN cord-009571-mygj2nd4 1792 10 in in IN cord-009571-mygj2nd4 1792 11 fractions fraction NNS cord-009571-mygj2nd4 1792 12 of of IN cord-009571-mygj2nd4 1792 13 IgM IgM NNP cord-009571-mygj2nd4 1792 14 or or CC cord-009571-mygj2nd4 1792 15 greater great JJR cord-009571-mygj2nd4 1792 16 density density NN cord-009571-mygj2nd4 1792 17 on on IN cord-009571-mygj2nd4 1792 18 sucrose sucrose NN cord-009571-mygj2nd4 1792 19 gradients gradient NNS cord-009571-mygj2nd4 1792 20 . . . cord-009571-mygj2nd4 1793 1 These these DT cord-009571-mygj2nd4 1793 2 findings finding NNS cord-009571-mygj2nd4 1793 3 are be VBP cord-009571-mygj2nd4 1793 4 compatible compatible JJ cord-009571-mygj2nd4 1793 5 with with IN cord-009571-mygj2nd4 1793 6 factors factor NNS cord-009571-mygj2nd4 1793 7 in in IN cord-009571-mygj2nd4 1793 8 SLE SLE NNP cord-009571-mygj2nd4 1793 9 sera sera NNP cord-009571-mygj2nd4 1793 10 , , , cord-009571-mygj2nd4 1793 11 most most RBS cord-009571-mygj2nd4 1793 12 likely likely JJ cord-009571-mygj2nd4 1793 13 immune immune JJ cord-009571-mygj2nd4 1793 14 complexes complex NNS cord-009571-mygj2nd4 1793 15 or or CC cord-009571-mygj2nd4 1793 16 antibodies antibody NNS cord-009571-mygj2nd4 1793 17 , , , cord-009571-mygj2nd4 1793 18 capable capable JJ cord-009571-mygj2nd4 1793 19 of of IN cord-009571-mygj2nd4 1793 20 inhibiting inhibit VBG cord-009571-mygj2nd4 1793 21 the the DT cord-009571-mygj2nd4 1793 22 natural natural JJ cord-009571-mygj2nd4 1793 23 killing killing NN cord-009571-mygj2nd4 1793 24 of of IN cord-009571-mygj2nd4 1793 25 tumor tumor NN cord-009571-mygj2nd4 1793 26 cell cell NN cord-009571-mygj2nd4 1793 27 lines line NNS cord-009571-mygj2nd4 1793 28 . . . cord-009571-mygj2nd4 1794 1 These these DT cord-009571-mygj2nd4 1794 2 factors factor NNS cord-009571-mygj2nd4 1794 3 may may MD cord-009571-mygj2nd4 1794 4 prevent prevent VB cord-009571-mygj2nd4 1794 5 cell cell NN cord-009571-mygj2nd4 1794 6 mediated mediate VBN cord-009571-mygj2nd4 1794 7 cytotoxic cytotoxic JJ cord-009571-mygj2nd4 1794 8 destruction destruction NN cord-009571-mygj2nd4 1794 9 of of IN cord-009571-mygj2nd4 1794 10 malignant malignant JJ cord-009571-mygj2nd4 1794 11 cells cell NNS cord-009571-mygj2nd4 1794 12 in in IN cord-009571-mygj2nd4 1794 13 vivo vivo NN cord-009571-mygj2nd4 1794 14 and and CC cord-009571-mygj2nd4 1794 15 may may MD cord-009571-mygj2nd4 1794 16 explain explain VB cord-009571-mygj2nd4 1794 17 the the DT cord-009571-mygj2nd4 1794 18 increased increase VBN cord-009571-mygj2nd4 1794 19 association association NN cord-009571-mygj2nd4 1794 20 of of IN cord-009571-mygj2nd4 1794 21 SLE SLE NNP cord-009571-mygj2nd4 1794 22 and and CC cord-009571-mygj2nd4 1794 23 malignancy malignancy NN cord-009571-mygj2nd4 1794 24 noted note VBN cord-009571-mygj2nd4 1794 25 by by IN cord-009571-mygj2nd4 1794 26 Canoso Canoso NNP cord-009571-mygj2nd4 1794 27 et et NNP cord-009571-mygj2nd4 1794 28 af af NN cord-009571-mygj2nd4 1794 29 . . . cord-009571-mygj2nd4 1795 1 ( ( -LRB- cord-009571-mygj2nd4 1795 2 Arthritis arthritis NN cord-009571-mygj2nd4 1795 3 Rheum Rheum NNP cord-009571-mygj2nd4 1795 4 17:383 17:383 CD cord-009571-mygj2nd4 1795 5 , , , cord-009571-mygj2nd4 1795 6 1974 1974 CD cord-009571-mygj2nd4 1795 7 ) ) -RRB- cord-009571-mygj2nd4 1795 8 . . . cord-009571-mygj2nd4 1796 1 Full full JJ cord-009571-mygj2nd4 1796 2 evaluation evaluation NN cord-009571-mygj2nd4 1796 3 of of IN cord-009571-mygj2nd4 1796 4 any any DT cord-009571-mygj2nd4 1796 5 hyperuricemic hyperuricemic JJ cord-009571-mygj2nd4 1796 6 patient patient NN cord-009571-mygj2nd4 1796 7 requires require VBZ cord-009571-mygj2nd4 1796 8 These these DT cord-009571-mygj2nd4 1796 9 problems problem NNS cord-009571-mygj2nd4 1796 10 can can MD cord-009571-mygj2nd4 1796 11 be be VB cord-009571-mygj2nd4 1796 12 largely largely RB cord-009571-mygj2nd4 1796 13 avoided avoid VBN cord-009571-mygj2nd4 1796 14 by by IN cord-009571-mygj2nd4 1796 15 assessing assess VBG cord-009571-mygj2nd4 1796 16 uric uric NN cord-009571-mygj2nd4 1796 17 acid acid NN cord-009571-mygj2nd4 1796 18 assessment assessment NN cord-009571-mygj2nd4 1796 19 of of IN cord-009571-mygj2nd4 1796 20 uric uric NN cord-009571-mygj2nd4 1796 21 acid acid NN cord-009571-mygj2nd4 1796 22 excretion excretion NN cord-009571-mygj2nd4 1796 23 , , , cord-009571-mygj2nd4 1796 24 but but CC cord-009571-mygj2nd4 1796 25 the the DT cord-009571-mygj2nd4 1796 26 standard standard JJ cord-009571-mygj2nd4 1796 27 24-hour 24-hour JJ cord-009571-mygj2nd4 1796 28 excretion excretion NN cord-009571-mygj2nd4 1796 29 per per IN cord-009571-mygj2nd4 1796 30 100 100 CD cord-009571-mygj2nd4 1796 31 ml ml NNS cord-009571-mygj2nd4 1796 32 of of IN cord-009571-mygj2nd4 1796 33 glomerular glomerular JJ cord-009571-mygj2nd4 1796 34 filtrate filtrate NN cord-009571-mygj2nd4 1796 35 . . . cord-009571-mygj2nd4 1797 1 This this DT cord-009571-mygj2nd4 1797 2 simple simple JJ cord-009571-mygj2nd4 1797 3 , , , cord-009571-mygj2nd4 1797 4 physiurine physiurine NN cord-009571-mygj2nd4 1797 5 method method NN cord-009571-mygj2nd4 1797 6 presents present VBZ cord-009571-mygj2nd4 1797 7 many many JJ cord-009571-mygj2nd4 1797 8 problems problem NNS cord-009571-mygj2nd4 1797 9 . . . cord-009571-mygj2nd4 1798 1 Ill Ill NNP cord-009571-mygj2nd4 1798 2 - - HYPH cord-009571-mygj2nd4 1798 3 timed time VBN cord-009571-mygj2nd4 1798 4 and and CC cord-009571-mygj2nd4 1798 5 inologically inologically RB cord-009571-mygj2nd4 1798 6 sound sound JJ cord-009571-mygj2nd4 1798 7 parameter parameter NN cord-009571-mygj2nd4 1798 8 is be VBZ cord-009571-mygj2nd4 1798 9 obtainable obtainable JJ cord-009571-mygj2nd4 1798 10 from from IN cord-009571-mygj2nd4 1798 11 single single JJ cord-009571-mygj2nd4 1798 12 , , , cord-009571-mygj2nd4 1798 13 untimed untimed JJ cord-009571-mygj2nd4 1798 14 complete complete JJ cord-009571-mygj2nd4 1798 15 collections collection NNS cord-009571-mygj2nd4 1798 16 may may MD cord-009571-mygj2nd4 1798 17 combine combine VB cord-009571-mygj2nd4 1798 18 with with IN cord-009571-mygj2nd4 1798 19 bacterial bacterial JJ cord-009571-mygj2nd4 1798 20 con con NN cord-009571-mygj2nd4 1798 21 - - HYPH cord-009571-mygj2nd4 1798 22 urine urine NN cord-009571-mygj2nd4 1798 23 specimens specimen NNS cord-009571-mygj2nd4 1798 24 by by IN cord-009571-mygj2nd4 1798 25 multiplying multiply VBG cord-009571-mygj2nd4 1798 26 urinary urinary JJ cord-009571-mygj2nd4 1798 27 uric uric NN cord-009571-mygj2nd4 1798 28 acid acid NN cord-009571-mygj2nd4 1798 29 by by IN cord-009571-mygj2nd4 1798 30 plasma plasma NN cord-009571-mygj2nd4 1798 31 tamination tamination NN cord-009571-mygj2nd4 1798 32 and and CC cord-009571-mygj2nd4 1798 33 crystal crystal NN cord-009571-mygj2nd4 1798 34 precipitation precipitation NN cord-009571-mygj2nd4 1798 35 to to TO cord-009571-mygj2nd4 1798 36 cause cause VB cord-009571-mygj2nd4 1798 37 significant significant JJ cord-009571-mygj2nd4 1798 38 errors error NNS cord-009571-mygj2nd4 1798 39 . . . cord-009571-mygj2nd4 1799 1 creatinine creatinine NN cord-009571-mygj2nd4 1799 2 and and CC cord-009571-mygj2nd4 1799 3 dividing divide VBG cord-009571-mygj2nd4 1799 4 by by IN cord-009571-mygj2nd4 1799 5 urinary urinary JJ cord-009571-mygj2nd4 1799 6 creatinine creatinine NN cord-009571-mygj2nd4 1799 7 ( ( -LRB- cord-009571-mygj2nd4 1799 8 all all DT cord-009571-mygj2nd4 1799 9 in in IN cord-009571-mygj2nd4 1799 10 mg/100 mg/100 NNS cord-009571-mygj2nd4 1799 11 ml ml NNP cord-009571-mygj2nd4 1799 12 ) ) -RRB- cord-009571-mygj2nd4 1799 13 . . . cord-009571-mygj2nd4 1800 1 To to TO cord-009571-mygj2nd4 1800 2 minimize minimize VB cord-009571-mygj2nd4 1800 3 possible possible JJ cord-009571-mygj2nd4 1800 4 diurnal diurnal JJ cord-009571-mygj2nd4 1800 5 effects effect NNS cord-009571-mygj2nd4 1800 6 on on IN cord-009571-mygj2nd4 1800 7 uric uric NN cord-009571-mygj2nd4 1800 8 acid acid NN cord-009571-mygj2nd4 1800 9 excretion excretion NN cord-009571-mygj2nd4 1800 10 , , , cord-009571-mygj2nd4 1800 11 all all DT cord-009571-mygj2nd4 1800 12 samples sample NNS cord-009571-mygj2nd4 1800 13 were be VBD cord-009571-mygj2nd4 1800 14 taken take VBN cord-009571-mygj2nd4 1800 15 in in IN cord-009571-mygj2nd4 1800 16 the the DT cord-009571-mygj2nd4 1800 17 morning morning NN cord-009571-mygj2nd4 1800 18 . . . cord-009571-mygj2nd4 1801 1 To to TO cord-009571-mygj2nd4 1801 2 evaluate evaluate VB cord-009571-mygj2nd4 1801 3 the the DT cord-009571-mygj2nd4 1801 4 precision precision NN cord-009571-mygj2nd4 1801 5 of of IN cord-009571-mygj2nd4 1801 6 the the DT cord-009571-mygj2nd4 1801 7 method method NN cord-009571-mygj2nd4 1801 8 , , , cord-009571-mygj2nd4 1801 9 15 15 CD cord-009571-mygj2nd4 1801 10 normal normal JJ cord-009571-mygj2nd4 1801 11 men man NNS cord-009571-mygj2nd4 1801 12 collected collect VBD cord-009571-mygj2nd4 1801 13 two two CD cord-009571-mygj2nd4 1801 14 24-hour 24-hour JJ cord-009571-mygj2nd4 1801 15 urines urine NNS cord-009571-mygj2nd4 1801 16 . . . cord-009571-mygj2nd4 1802 1 Spot spot JJ cord-009571-mygj2nd4 1802 2 urine urine NN cord-009571-mygj2nd4 1802 3 specimens specimen NNS cord-009571-mygj2nd4 1802 4 with with IN cord-009571-mygj2nd4 1802 5 concurrent concurrent JJ cord-009571-mygj2nd4 1802 6 serum serum NN cord-009571-mygj2nd4 1802 7 samples sample NNS cord-009571-mygj2nd4 1802 8 were be VBD cord-009571-mygj2nd4 1802 9 also also RB cord-009571-mygj2nd4 1802 10 obtained obtain VBN cord-009571-mygj2nd4 1802 11 on on IN cord-009571-mygj2nd4 1802 12 two two CD cord-009571-mygj2nd4 1802 13 separate separate JJ cord-009571-mygj2nd4 1802 14 mornings morning NNS cord-009571-mygj2nd4 1802 15 . . . cord-009571-mygj2nd4 1803 1 Uric uric NN cord-009571-mygj2nd4 1803 2 acid acid NN cord-009571-mygj2nd4 1803 3 was be VBD cord-009571-mygj2nd4 1803 4 measured measure VBN cord-009571-mygj2nd4 1803 5 spectrophotometrically spectrophotometrically RB cord-009571-mygj2nd4 1803 6 , , , cord-009571-mygj2nd4 1803 7 and and CC cord-009571-mygj2nd4 1803 8 creatinine creatinine NN cord-009571-mygj2nd4 1803 9 was be VBD cord-009571-mygj2nd4 1803 10 measured measure VBN cord-009571-mygj2nd4 1803 11 by by IN cord-009571-mygj2nd4 1803 12 standard standard JJ cord-009571-mygj2nd4 1803 13 autoanalyzer autoanalyzer NN cord-009571-mygj2nd4 1803 14 technique technique NN cord-009571-mygj2nd4 1803 15 . . . cord-009571-mygj2nd4 1804 1 The the DT cord-009571-mygj2nd4 1804 2 coefficient coefficient NN cord-009571-mygj2nd4 1804 3 of of IN cord-009571-mygj2nd4 1804 4 variation variation NN cord-009571-mygj2nd4 1804 5 ( ( -LRB- cord-009571-mygj2nd4 1804 6 SD SD NNP cord-009571-mygj2nd4 1804 7 / / SYM cord-009571-mygj2nd4 1804 8 X X NNP cord-009571-mygj2nd4 1804 9 ) ) -RRB- cord-009571-mygj2nd4 1804 10 was be VBD cord-009571-mygj2nd4 1804 11 3 3 CD cord-009571-mygj2nd4 1804 12 I% i% NN cord-009571-mygj2nd4 1804 13 for for IN cord-009571-mygj2nd4 1804 14 paired pair VBN cord-009571-mygj2nd4 1804 15 , , , cord-009571-mygj2nd4 1804 16 quantitative quantitative JJ cord-009571-mygj2nd4 1804 17 24-hour 24-hour JJ cord-009571-mygj2nd4 1804 18 urine urine NN cord-009571-mygj2nd4 1804 19 uric uric NN cord-009571-mygj2nd4 1804 20 acid acid NN cord-009571-mygj2nd4 1804 21 determinations determination NNS cord-009571-mygj2nd4 1804 22 , , , cord-009571-mygj2nd4 1804 23 while while IN cord-009571-mygj2nd4 1804 24 spot spot NN cord-009571-mygj2nd4 1804 25 , , , cord-009571-mygj2nd4 1804 26 mid mid NN cord-009571-mygj2nd4 1804 27 - - JJ cord-009571-mygj2nd4 1804 28 morning morning JJ cord-009571-mygj2nd4 1804 29 assessments assessment NNS cord-009571-mygj2nd4 1804 30 of of IN cord-009571-mygj2nd4 1804 31 uric uric NN cord-009571-mygj2nd4 1804 32 acid acid NN cord-009571-mygj2nd4 1804 33 excretion excretion NN cord-009571-mygj2nd4 1804 34 per per IN cord-009571-mygj2nd4 1804 35 100 100 CD cord-009571-mygj2nd4 1804 36 ml ml NNS cord-009571-mygj2nd4 1804 37 of of IN cord-009571-mygj2nd4 1804 38 glomerular glomerular JJ cord-009571-mygj2nd4 1804 39 filtrate filtrate NN cord-009571-mygj2nd4 1804 40 had have VBD cord-009571-mygj2nd4 1804 41 a a DT cord-009571-mygj2nd4 1804 42 more more RBR cord-009571-mygj2nd4 1804 43 satisfactory satisfactory JJ cord-009571-mygj2nd4 1804 44 coefficient coefficient NN cord-009571-mygj2nd4 1804 45 of of IN cord-009571-mygj2nd4 1804 46 21 21 CD cord-009571-mygj2nd4 1804 47 % % NN cord-009571-mygj2nd4 1804 48 . . . cord-009571-mygj2nd4 1805 1 Since since IN cord-009571-mygj2nd4 1805 2 most most JJS cord-009571-mygj2nd4 1805 3 laboratories laboratory NNS cord-009571-mygj2nd4 1805 4 do do VBP cord-009571-mygj2nd4 1805 5 not not RB cord-009571-mygj2nd4 1805 6 employ employ VB cord-009571-mygj2nd4 1805 7 the the DT cord-009571-mygj2nd4 1805 8 enzymatic enzymatic JJ cord-009571-mygj2nd4 1805 9 spectrophotometric spectrophotometric JJ cord-009571-mygj2nd4 1805 10 method method NN cord-009571-mygj2nd4 1805 11 , , , cord-009571-mygj2nd4 1805 12 urine urine NN cord-009571-mygj2nd4 1805 13 uric uric NN cord-009571-mygj2nd4 1805 14 acid acid NN cord-009571-mygj2nd4 1805 15 determinations determination NNS cord-009571-mygj2nd4 1805 16 were be VBD cord-009571-mygj2nd4 1805 17 also also RB cord-009571-mygj2nd4 1805 18 performed perform VBN cord-009571-mygj2nd4 1805 19 by by IN cord-009571-mygj2nd4 1805 20 a a DT cord-009571-mygj2nd4 1805 21 colorimetric colorimetric JJ cord-009571-mygj2nd4 1805 22 , , , cord-009571-mygj2nd4 1805 23 autoanalyzer autoanalyzer NN cord-009571-mygj2nd4 1805 24 technique technique NN cord-009571-mygj2nd4 1805 25 . . . cord-009571-mygj2nd4 1806 1 These these DT cord-009571-mygj2nd4 1806 2 values value NNS cord-009571-mygj2nd4 1806 3 correlated correlate VBD cord-009571-mygj2nd4 1806 4 well well RB cord-009571-mygj2nd4 1806 5 ( ( -LRB- cord-009571-mygj2nd4 1806 6 r r NN cord-009571-mygj2nd4 1806 7 = = SYM cord-009571-mygj2nd4 1806 8 0.90 0.90 CD cord-009571-mygj2nd4 1806 9 ) ) -RRB- cord-009571-mygj2nd4 1806 10 with with IN cord-009571-mygj2nd4 1806 11 the the DT cord-009571-mygj2nd4 1806 12 more more RBR cord-009571-mygj2nd4 1806 13 specific specific JJ cord-009571-mygj2nd4 1806 14 spectrophotometric spectrophotometric JJ cord-009571-mygj2nd4 1806 15 findings finding NNS cord-009571-mygj2nd4 1806 16 , , , cord-009571-mygj2nd4 1806 17 but but CC cord-009571-mygj2nd4 1806 18 were be VBD cord-009571-mygj2nd4 1806 19 an an DT cord-009571-mygj2nd4 1806 20 average average NN cord-009571-mygj2nd4 1806 21 of of IN cord-009571-mygj2nd4 1806 22 7 7 CD cord-009571-mygj2nd4 1806 23 % % NN cord-009571-mygj2nd4 1806 24 higher high JJR cord-009571-mygj2nd4 1806 25 . . . cord-009571-mygj2nd4 1807 1 Samples sample NNS cord-009571-mygj2nd4 1807 2 from from IN cord-009571-mygj2nd4 1807 3 23 23 CD cord-009571-mygj2nd4 1807 4 normal normal JJ cord-009571-mygj2nd4 1807 5 , , , cord-009571-mygj2nd4 1807 6 adult adult NN cord-009571-mygj2nd4 1807 7 men man NNS cord-009571-mygj2nd4 1807 8 , , , cord-009571-mygj2nd4 1807 9 the the DT cord-009571-mygj2nd4 1807 10 mean mean JJ cord-009571-mygj2nd4 1807 11 urinary urinary JJ cord-009571-mygj2nd4 1807 12 excretion excretion NN cord-009571-mygj2nd4 1807 13 of of IN cord-009571-mygj2nd4 1807 14 uric uric NN cord-009571-mygj2nd4 1807 15 acid acid NN cord-009571-mygj2nd4 1807 16 in in IN cord-009571-mygj2nd4 1807 17 mid mid NN cord-009571-mygj2nd4 1807 18 - - NN cord-009571-mygj2nd4 1807 19 morning morning NN cord-009571-mygj2nd4 1807 20 was be VBD cord-009571-mygj2nd4 1808 1 0.405 0.405 CD cord-009571-mygj2nd4 1808 2 f f NNP cord-009571-mygj2nd4 1808 3 0.098 0.098 CD cord-009571-mygj2nd4 1809 1 mg/ mg/ NNP cord-009571-mygj2nd4 1809 2 100 100 CD cord-009571-mygj2nd4 1809 3 ml ml NNP cord-009571-mygj2nd4 1809 4 ( ( -LRB- cord-009571-mygj2nd4 1809 5 SD SD NNP cord-009571-mygj2nd4 1809 6 ) ) -RRB- cord-009571-mygj2nd4 1809 7 , , , cord-009571-mygj2nd4 1809 8 while while IN cord-009571-mygj2nd4 1809 9 19 19 CD cord-009571-mygj2nd4 1809 10 gouty gouty JJ cord-009571-mygj2nd4 1809 11 men man NNS cord-009571-mygj2nd4 1809 12 ( ( -LRB- cord-009571-mygj2nd4 1809 13 studied study VBN cord-009571-mygj2nd4 1809 14 between between IN cord-009571-mygj2nd4 1809 15 attacks attack NNS cord-009571-mygj2nd4 1809 16 and and CC cord-009571-mygj2nd4 1809 17 off off IN cord-009571-mygj2nd4 1809 18 hypouricemic hypouricemic NNP cord-009571-mygj2nd4 1809 19 drugs drug NNS cord-009571-mygj2nd4 1809 20 ) ) -RRB- cord-009571-mygj2nd4 1809 21 had have VBD cord-009571-mygj2nd4 1809 22 a a DT cord-009571-mygj2nd4 1809 23 mean mean NN cord-009571-mygj2nd4 1809 24 of of IN cord-009571-mygj2nd4 1809 25 0.679 0.679 CD cord-009571-mygj2nd4 1809 26 f f NN cord-009571-mygj2nd4 1809 27 0.423 0.423 CD cord-009571-mygj2nd4 1809 28 mg/100 mg/100 NNS cord-009571-mygj2nd4 1809 29 ml ml NNP cord-009571-mygj2nd4 1809 30 . . . cord-009571-mygj2nd4 1810 1 Included include VBN cord-009571-mygj2nd4 1810 2 in in IN cord-009571-mygj2nd4 1810 3 the the DT cord-009571-mygj2nd4 1810 4 latter latter JJ cord-009571-mygj2nd4 1810 5 group group NN cord-009571-mygj2nd4 1810 6 were be VBD cord-009571-mygj2nd4 1810 7 5 5 CD cord-009571-mygj2nd4 1810 8 significant significant JJ cord-009571-mygj2nd4 1810 9 overexcretors overexcretor NNS cord-009571-mygj2nd4 1810 10 with with IN cord-009571-mygj2nd4 1810 11 values value NNS cord-009571-mygj2nd4 1810 12 of of IN cord-009571-mygj2nd4 1810 13 0.821 0.821 CD cord-009571-mygj2nd4 1810 14 , , , cord-009571-mygj2nd4 1810 15 0.905 0.905 CD cord-009571-mygj2nd4 1810 16 , , , cord-009571-mygj2nd4 1810 17 0.982 0.982 CD cord-009571-mygj2nd4 1810 18 , , , cord-009571-mygj2nd4 1810 19 1.45 1.45 CD cord-009571-mygj2nd4 1810 20 , , , cord-009571-mygj2nd4 1810 21 and and CC cord-009571-mygj2nd4 1810 22 2.01 2.01 CD cord-009571-mygj2nd4 1810 23 mg mg NNS cord-009571-mygj2nd4 1810 24 of of IN cord-009571-mygj2nd4 1810 25 uric uric NN cord-009571-mygj2nd4 1810 26 acid acid NN cord-009571-mygj2nd4 1810 27 per per IN cord-009571-mygj2nd4 1810 28 100 100 CD cord-009571-mygj2nd4 1810 29 ml ml NNS cord-009571-mygj2nd4 1810 30 of of IN cord-009571-mygj2nd4 1810 31 glornerular glornerular NNP cord-009571-mygj2nd4 1810 32 filtrate filtrate NNP cord-009571-mygj2nd4 1810 33 . . . cord-009571-mygj2nd4 1811 1 We -PRON- PRP cord-009571-mygj2nd4 1811 2 believe believe VBP cord-009571-mygj2nd4 1811 3 that that IN cord-009571-mygj2nd4 1811 4 this this DT cord-009571-mygj2nd4 1811 5 assessment assessment NN cord-009571-mygj2nd4 1811 6 of of IN cord-009571-mygj2nd4 1811 7 mid mid JJ cord-009571-mygj2nd4 1811 8 - - JJ cord-009571-mygj2nd4 1811 9 morning morning JJ cord-009571-mygj2nd4 1811 10 serum serum NN cord-009571-mygj2nd4 1811 11 and and CC cord-009571-mygj2nd4 1811 12 urine urine NN cord-009571-mygj2nd4 1811 13 samples sample NNS cord-009571-mygj2nd4 1811 14 effectively effectively RB cord-009571-mygj2nd4 1811 15 identifies identify VBZ cord-009571-mygj2nd4 1811 16 overexcretors overexcretor NNS cord-009571-mygj2nd4 1811 17 of of IN cord-009571-mygj2nd4 1811 18 uric uric NN cord-009571-mygj2nd4 1811 19 acid acid NN cord-009571-mygj2nd4 1811 20 . . . cord-009571-mygj2nd4 1812 1 In in IN cord-009571-mygj2nd4 1812 2 addition addition NN cord-009571-mygj2nd4 1812 3 , , , cord-009571-mygj2nd4 1812 4 it -PRON- PRP cord-009571-mygj2nd4 1812 5 is be VBZ cord-009571-mygj2nd4 1812 6 more more RBR cord-009571-mygj2nd4 1812 7 convenient convenient JJ cord-009571-mygj2nd4 1812 8 , , , cord-009571-mygj2nd4 1812 9 more more RBR cord-009571-mygj2nd4 1812 10 physiological physiological JJ cord-009571-mygj2nd4 1812 11 , , , cord-009571-mygj2nd4 1812 12 and and CC cord-009571-mygj2nd4 1812 13 more more RBR cord-009571-mygj2nd4 1812 14 precise precise JJ cord-009571-mygj2nd4 1812 15 than than IN cord-009571-mygj2nd4 1812 16 the the DT cord-009571-mygj2nd4 1812 17 conventional conventional JJ cord-009571-mygj2nd4 1812 18 24-hour 24-hour JJ cord-009571-mygj2nd4 1812 19 method method NN cord-009571-mygj2nd4 1812 20 . . . cord-009571-mygj2nd4 1813 1 ( ( -LRB- cord-009571-mygj2nd4 1813 2 Supported support VBN cord-009571-mygj2nd4 1813 3 by by IN cord-009571-mygj2nd4 1813 4 NIH NIH NNP cord-009571-mygj2nd4 1813 5 Grant Grant NNP cord-009571-mygj2nd4 1813 6 AM13925 AM13925 NNP cord-009571-mygj2nd4 1813 7 . . . cord-009571-mygj2nd4 1813 8 ) ) -RRB- cord-009571-mygj2nd4 1814 1 In in IN cord-009571-mygj2nd4 1814 2 mixed mixed JJ cord-009571-mygj2nd4 1814 3 connective connective JJ cord-009571-mygj2nd4 1814 4 tissue tissue NN cord-009571-mygj2nd4 1814 5 disease disease NN cord-009571-mygj2nd4 1814 6 ( ( -LRB- cord-009571-mygj2nd4 1814 7 MCTD MCTD NNP cord-009571-mygj2nd4 1814 8 ) ) -RRB- cord-009571-mygj2nd4 1814 9 , , , cord-009571-mygj2nd4 1814 10 a a DT cord-009571-mygj2nd4 1814 11 newly newly RB cord-009571-mygj2nd4 1814 12 described describe VBN cord-009571-mygj2nd4 1814 13 rheumatic rheumatic JJ cord-009571-mygj2nd4 1814 14 syndrome syndrome NN cord-009571-mygj2nd4 1814 15 , , , cord-009571-mygj2nd4 1814 16 no no DT cord-009571-mygj2nd4 1814 17 comprehensive comprehensive JJ cord-009571-mygj2nd4 1814 18 histopathologic histopathologic JJ cord-009571-mygj2nd4 1814 19 descriptions description NNS cord-009571-mygj2nd4 1814 20 exist exist VBP cord-009571-mygj2nd4 1814 21 . . . cord-009571-mygj2nd4 1815 1 We -PRON- PRP cord-009571-mygj2nd4 1815 2 have have VBP cord-009571-mygj2nd4 1815 3 followed follow VBN cord-009571-mygj2nd4 1815 4 16 16 CD cord-009571-mygj2nd4 1815 5 MCTD MCTD NNP cord-009571-mygj2nd4 1815 6 children child NNS cord-009571-mygj2nd4 1815 7 over over IN cord-009571-mygj2nd4 1815 8 a a DT cord-009571-mygj2nd4 1815 9 range range NN cord-009571-mygj2nd4 1815 10 of of IN cord-009571-mygj2nd4 1815 11 1 1 CD cord-009571-mygj2nd4 1815 12 - - SYM cord-009571-mygj2nd4 1815 13 1 1 CD cord-009571-mygj2nd4 1815 14 1 1 CD cord-009571-mygj2nd4 1815 15 years year NNS cord-009571-mygj2nd4 1815 16 , , , cord-009571-mygj2nd4 1815 17 ( ( -LRB- cord-009571-mygj2nd4 1815 18 mean mean VBP cord-009571-mygj2nd4 1815 19 6 6 CD cord-009571-mygj2nd4 1815 20 years year NNS cord-009571-mygj2nd4 1815 21 ) ) -RRB- cord-009571-mygj2nd4 1815 22 ; ; : cord-009571-mygj2nd4 1815 23 4 4 CD cord-009571-mygj2nd4 1815 24 have have VBP cord-009571-mygj2nd4 1815 25 died die VBN cord-009571-mygj2nd4 1815 26 . . . cord-009571-mygj2nd4 1816 1 Three three CD cord-009571-mygj2nd4 1816 2 autopsies autopsy NNS cord-009571-mygj2nd4 1816 3 and and CC cord-009571-mygj2nd4 1816 4 6 6 CD cord-009571-mygj2nd4 1816 5 renal renal JJ cord-009571-mygj2nd4 1816 6 and and CC cord-009571-mygj2nd4 1816 7 3 3 CD cord-009571-mygj2nd4 1816 8 muscle muscle NN cord-009571-mygj2nd4 1816 9 biopsies biopsy NNS cord-009571-mygj2nd4 1816 10 were be VBD cord-009571-mygj2nd4 1816 11 reviewed review VBN cord-009571-mygj2nd4 1816 12 . . . cord-009571-mygj2nd4 1817 1 Among among IN cord-009571-mygj2nd4 1817 2 adults adult NNS cord-009571-mygj2nd4 1817 3 with with IN cord-009571-mygj2nd4 1817 4 MCTD MCTD NNP cord-009571-mygj2nd4 1817 5 , , , cord-009571-mygj2nd4 1817 6 tissues tissue NNS cord-009571-mygj2nd4 1817 7 from from IN cord-009571-mygj2nd4 1817 8 2 2 CD cord-009571-mygj2nd4 1817 9 autopsies autopsy NNS cord-009571-mygj2nd4 1817 10 , , , cord-009571-mygj2nd4 1817 11 and and CC cord-009571-mygj2nd4 1817 12 18 18 CD cord-009571-mygj2nd4 1817 13 kidney kidney NN cord-009571-mygj2nd4 1817 14 , , , cord-009571-mygj2nd4 1817 15 21 21 CD cord-009571-mygj2nd4 1817 16 muscle muscle NN cord-009571-mygj2nd4 1817 17 , , , cord-009571-mygj2nd4 1817 18 and and CC cord-009571-mygj2nd4 1817 19 4 4 CD cord-009571-mygj2nd4 1817 20 lung lung NN cord-009571-mygj2nd4 1817 21 biopsies biopsy NNS cord-009571-mygj2nd4 1817 22 were be VBD cord-009571-mygj2nd4 1817 23 reviewed review VBN cord-009571-mygj2nd4 1817 24 . . . cord-009571-mygj2nd4 1818 1 In in IN cord-009571-mygj2nd4 1818 2 children child NNS cord-009571-mygj2nd4 1818 3 , , , cord-009571-mygj2nd4 1818 4 proliferative proliferative JJ cord-009571-mygj2nd4 1818 5 vascular vascular JJ cord-009571-mygj2nd4 1818 6 lesions lesion NNS cord-009571-mygj2nd4 1818 7 , , , cord-009571-mygj2nd4 1818 8 with with IN cord-009571-mygj2nd4 1818 9 intimal intimal JJ cord-009571-mygj2nd4 1818 10 and and CC cord-009571-mygj2nd4 1818 11 medial medial JJ cord-009571-mygj2nd4 1818 12 thickening thickening NN cord-009571-mygj2nd4 1818 13 and and CC cord-009571-mygj2nd4 1818 14 luminal luminal JJ cord-009571-mygj2nd4 1818 15 narrowing narrowing NN cord-009571-mygj2nd4 1818 16 but but CC cord-009571-mygj2nd4 1818 17 without without IN cord-009571-mygj2nd4 1818 18 fibrinoid fibrinoid JJ cord-009571-mygj2nd4 1818 19 or or CC cord-009571-mygj2nd4 1818 20 inflammatory inflammatory JJ cord-009571-mygj2nd4 1818 21 change change NN cord-009571-mygj2nd4 1818 22 , , , cord-009571-mygj2nd4 1818 23 affected affect VBD cord-009571-mygj2nd4 1818 24 large large JJ cord-009571-mygj2nd4 1818 25 vessels vessel NNS cord-009571-mygj2nd4 1818 26 ( ( -LRB- cord-009571-mygj2nd4 1818 27 aorta aorta NN cord-009571-mygj2nd4 1818 28 , , , cord-009571-mygj2nd4 1818 29 coronary coronary JJ cord-009571-mygj2nd4 1818 30 , , , cord-009571-mygj2nd4 1818 31 renal renal JJ cord-009571-mygj2nd4 1818 32 ) ) -RRB- cord-009571-mygj2nd4 1818 33 , , , cord-009571-mygj2nd4 1818 34 and and CC cord-009571-mygj2nd4 1818 35 small small JJ cord-009571-mygj2nd4 1818 36 arterioles arteriole NNS cord-009571-mygj2nd4 1818 37 of of IN cord-009571-mygj2nd4 1818 38 many many JJ cord-009571-mygj2nd4 1818 39 organs organ NNS cord-009571-mygj2nd4 1818 40 . . . cord-009571-mygj2nd4 1819 1 Inflammatory inflammatory JJ cord-009571-mygj2nd4 1819 2 infiltration infiltration NN cord-009571-mygj2nd4 1819 3 , , , cord-009571-mygj2nd4 1819 4 predominantly predominantly RB cord-009571-mygj2nd4 1819 5 plasmacytic plasmacytic JJ cord-009571-mygj2nd4 1819 6 , , , cord-009571-mygj2nd4 1819 7 was be VBD cord-009571-mygj2nd4 1819 8 marked mark VBN cord-009571-mygj2nd4 1819 9 in in IN cord-009571-mygj2nd4 1819 10 skeletal skeletal JJ cord-009571-mygj2nd4 1819 11 muscle muscle NN cord-009571-mygj2nd4 1819 12 6:6 6:6 CD cord-009571-mygj2nd4 1819 13 , , , cord-009571-mygj2nd4 1819 14 liver liver NN cord-009571-mygj2nd4 1819 15 3 3 CD cord-009571-mygj2nd4 1819 16 : : SYM cord-009571-mygj2nd4 1819 17 3 3 CD cord-009571-mygj2nd4 1819 18 , , , cord-009571-mygj2nd4 1819 19 salivary salivary JJ cord-009571-mygj2nd4 1819 20 glands gland NNS cord-009571-mygj2nd4 1819 21 2 2 CD cord-009571-mygj2nd4 1819 22 : : SYM cord-009571-mygj2nd4 1819 23 2 2 CD cord-009571-mygj2nd4 1819 24 , , , cord-009571-mygj2nd4 1819 25 intestine intestine NN cord-009571-mygj2nd4 1819 26 3 3 CD cord-009571-mygj2nd4 1819 27 : : SYM cord-009571-mygj2nd4 1819 28 3 3 CD cord-009571-mygj2nd4 1819 29 , , , cord-009571-mygj2nd4 1819 30 and and CC cord-009571-mygj2nd4 1819 31 heart heart NN cord-009571-mygj2nd4 1819 32 3 3 CD cord-009571-mygj2nd4 1819 33 : : SYM cord-009571-mygj2nd4 1819 34 3 3 CD cord-009571-mygj2nd4 1819 35 . . . cord-009571-mygj2nd4 1820 1 Distinctive distinctive JJ cord-009571-mygj2nd4 1820 2 lesions lesion NNS cord-009571-mygj2nd4 1820 3 of of IN cord-009571-mygj2nd4 1820 4 esophagus esophagu NNS cord-009571-mygj2nd4 1820 5 ( ( -LRB- cord-009571-mygj2nd4 1820 6 atrophy atrophy NN cord-009571-mygj2nd4 1820 7 of of IN cord-009571-mygj2nd4 1820 8 inner inner JJ cord-009571-mygj2nd4 1820 9 muscle muscle NN cord-009571-mygj2nd4 1820 10 layer layer NN cord-009571-mygj2nd4 1820 11 ) ) -RRB- cord-009571-mygj2nd4 1820 12 , , , cord-009571-mygj2nd4 1820 13 thymus thymus NN cord-009571-mygj2nd4 1820 14 ( ( -LRB- cord-009571-mygj2nd4 1820 15 hyperplasia hyperplasia NN cord-009571-mygj2nd4 1820 16 ) ) -RRB- cord-009571-mygj2nd4 1820 17 , , , cord-009571-mygj2nd4 1820 18 kidney kidney NN cord-009571-mygj2nd4 1820 19 ( ( -LRB- cord-009571-mygj2nd4 1820 20 membranous membranous JJ cord-009571-mygj2nd4 1820 21 change change NN cord-009571-mygj2nd4 1820 22 ) ) -RRB- cord-009571-mygj2nd4 1820 23 , , , cord-009571-mygj2nd4 1820 24 liver liver NN cord-009571-mygj2nd4 1820 25 , , , cord-009571-mygj2nd4 1820 26 lung lung NN cord-009571-mygj2nd4 1820 27 , , , cord-009571-mygj2nd4 1820 28 and and CC cord-009571-mygj2nd4 1820 29 salivary salivary NN cord-009571-mygj2nd4 1820 30 glands gland NNS cord-009571-mygj2nd4 1820 31 differed differ VBD cord-009571-mygj2nd4 1820 32 significantly significantly RB cord-009571-mygj2nd4 1820 33 from from IN cord-009571-mygj2nd4 1820 34 those those DT cord-009571-mygj2nd4 1820 35 expected expect VBN cord-009571-mygj2nd4 1820 36 in in IN cord-009571-mygj2nd4 1820 37 childhood childhood NN cord-009571-mygj2nd4 1820 38 systemic systemic JJ cord-009571-mygj2nd4 1820 39 lupus lupus NN cord-009571-mygj2nd4 1820 40 erythematosus erythematosus NN cord-009571-mygj2nd4 1820 41 , , , cord-009571-mygj2nd4 1820 42 polyarteritis polyarteritis NN cord-009571-mygj2nd4 1820 43 , , , cord-009571-mygj2nd4 1820 44 or or CC cord-009571-mygj2nd4 1820 45 scleroderma scleroderma NN cord-009571-mygj2nd4 1820 46 . . . cord-009571-mygj2nd4 1821 1 Many many JJ cord-009571-mygj2nd4 1821 2 of of IN cord-009571-mygj2nd4 1821 3 these these DT cord-009571-mygj2nd4 1821 4 organs organ NNS cord-009571-mygj2nd4 1821 5 were be VBD cord-009571-mygj2nd4 1821 6 not not RB cord-009571-mygj2nd4 1821 7 clinically clinically RB cord-009571-mygj2nd4 1821 8 involved involved JJ cord-009571-mygj2nd4 1821 9 during during IN cord-009571-mygj2nd4 1821 10 life life NN cord-009571-mygj2nd4 1821 11 . . . cord-009571-mygj2nd4 1822 1 Histologic Histologic NNP cord-009571-mygj2nd4 1822 2 estimates estimate NNS cord-009571-mygj2nd4 1822 3 of of IN cord-009571-mygj2nd4 1822 4 numbers number NNS cord-009571-mygj2nd4 1822 5 of of IN cord-009571-mygj2nd4 1822 6 T T NNP cord-009571-mygj2nd4 1822 7 and and CC cord-009571-mygj2nd4 1822 8 B b NN cord-009571-mygj2nd4 1822 9 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 1822 10 in in IN cord-009571-mygj2nd4 1822 11 spleen spleen NN cord-009571-mygj2nd4 1822 12 and and CC cord-009571-mygj2nd4 1822 13 lymph lymph NN cord-009571-mygj2nd4 1822 14 nodes node NNS cord-009571-mygj2nd4 1822 15 , , , cord-009571-mygj2nd4 1822 16 and and CC cord-009571-mygj2nd4 1822 17 degree degree NN cord-009571-mygj2nd4 1822 18 of of IN cord-009571-mygj2nd4 1822 19 plasmacytosis plasmacytosis NN cord-009571-mygj2nd4 1822 20 ( ( -LRB- cord-009571-mygj2nd4 1822 21 with with IN cord-009571-mygj2nd4 1822 22 hyperglobulinemia hyperglobulinemia NNP cord-009571-mygj2nd4 1822 23 ) ) -RRB- cord-009571-mygj2nd4 1822 24 , , , cord-009571-mygj2nd4 1822 25 differ differ VBP cord-009571-mygj2nd4 1822 26 from from IN cord-009571-mygj2nd4 1822 27 systemic systemic JJ cord-009571-mygj2nd4 1822 28 lupus lupus NN cord-009571-mygj2nd4 1822 29 erythematosus erythematosus NN cord-009571-mygj2nd4 1822 30 and and CC cord-009571-mygj2nd4 1822 31 juvenile juvenile JJ cord-009571-mygj2nd4 1822 32 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1822 33 arthritis arthritis NN cord-009571-mygj2nd4 1822 34 . . . cord-009571-mygj2nd4 1823 1 In in IN cord-009571-mygj2nd4 1823 2 adults adult NNS cord-009571-mygj2nd4 1823 3 with with IN cord-009571-mygj2nd4 1823 4 MCTD MCTD NNP cord-009571-mygj2nd4 1823 5 , , , cord-009571-mygj2nd4 1823 6 muscle muscle NN cord-009571-mygj2nd4 1823 7 changes change NNS cord-009571-mygj2nd4 1823 8 included include VBD cord-009571-mygj2nd4 1823 9 : : : cord-009571-mygj2nd4 1823 10 diffuse diffuse VB cord-009571-mygj2nd4 1823 11 inflammatory inflammatory JJ cord-009571-mygj2nd4 1823 12 infiltrate infiltrate NN cord-009571-mygj2nd4 1823 13 15:21 15:21 CD cord-009571-mygj2nd4 1823 14 ( ( -LRB- cord-009571-mygj2nd4 1823 15 perior perior NNP cord-009571-mygj2nd4 1823 16 endomesial endomesial NNP cord-009571-mygj2nd4 1823 17 , , , cord-009571-mygj2nd4 1823 18 and and CC cord-009571-mygj2nd4 1823 19 perior perior NNP cord-009571-mygj2nd4 1823 20 intravascular intravascular JJ cord-009571-mygj2nd4 1823 21 ) ) -RRB- cord-009571-mygj2nd4 1823 22 . . . cord-009571-mygj2nd4 1824 1 By by IN cord-009571-mygj2nd4 1824 2 ATP ATP NNP cord-009571-mygj2nd4 1824 3 - - HYPH cord-009571-mygj2nd4 1824 4 ase ase NNP cord-009571-mygj2nd4 1824 5 , , , cord-009571-mygj2nd4 1824 6 5 5 CD cord-009571-mygj2nd4 1824 7 : : : cord-009571-mygj2nd4 1824 8 I -PRON- PRP cord-009571-mygj2nd4 1824 9 I -PRON- PRP cord-009571-mygj2nd4 1824 10 had have VBD cord-009571-mygj2nd4 1824 11 type type NN cord-009571-mygj2nd4 1824 12 I -PRON- PRP cord-009571-mygj2nd4 1824 13 fiber fiber NN cord-009571-mygj2nd4 1824 14 predominance predominance NN cord-009571-mygj2nd4 1824 15 . . . cord-009571-mygj2nd4 1825 1 On on IN cord-009571-mygj2nd4 1825 2 muscle muscle NN cord-009571-mygj2nd4 1825 3 immunofluorescence immunofluorescence NN cord-009571-mygj2nd4 1825 4 , , , cord-009571-mygj2nd4 1825 5 8 8 CD cord-009571-mygj2nd4 1825 6 : : SYM cord-009571-mygj2nd4 1825 7 10 10 CD cord-009571-mygj2nd4 1825 8 had have VBD cord-009571-mygj2nd4 1825 9 vascular vascular JJ cord-009571-mygj2nd4 1825 10 , , , cord-009571-mygj2nd4 1825 11 sarcolemmal sarcolemmal JJ cord-009571-mygj2nd4 1825 12 basement basement NN cord-009571-mygj2nd4 1825 13 membrane membrane NN cord-009571-mygj2nd4 1825 14 , , , cord-009571-mygj2nd4 1825 15 or or CC cord-009571-mygj2nd4 1825 16 granular granular JJ cord-009571-mygj2nd4 1825 17 fiber fiber NN cord-009571-mygj2nd4 1825 18 staining staining NN cord-009571-mygj2nd4 1825 19 , , , cord-009571-mygj2nd4 1825 20 with with IN cord-009571-mygj2nd4 1825 21 IgG igg NN cord-009571-mygj2nd4 1825 22 or or CC cord-009571-mygj2nd4 1825 23 IgM. IgM. NNP cord-009571-mygj2nd4 1825 24 In in IN cord-009571-mygj2nd4 1825 25 20 20 CD cord-009571-mygj2nd4 1825 26 kidneys kidney NNS cord-009571-mygj2nd4 1825 27 there there EX cord-009571-mygj2nd4 1825 28 were be VBD cord-009571-mygj2nd4 1825 29 included include VBN cord-009571-mygj2nd4 1825 30 : : : cord-009571-mygj2nd4 1825 31 mesangial mesangial JJ cord-009571-mygj2nd4 1825 32 proliferation proliferation NN cord-009571-mygj2nd4 1825 33 5 5 CD cord-009571-mygj2nd4 1825 34 , , , cord-009571-mygj2nd4 1825 35 focal focal JJ cord-009571-mygj2nd4 1825 36 - - HYPH cord-009571-mygj2nd4 1825 37 local local JJ cord-009571-mygj2nd4 1825 38 change change NN cord-009571-mygj2nd4 1825 39 5 5 CD cord-009571-mygj2nd4 1825 40 , , , cord-009571-mygj2nd4 1825 41 membranous membranous JJ cord-009571-mygj2nd4 1825 42 3 3 CD cord-009571-mygj2nd4 1825 43 , , , cord-009571-mygj2nd4 1825 44 membrano membrano NN cord-009571-mygj2nd4 1825 45 - - HYPH cord-009571-mygj2nd4 1825 46 proliferative proliferative JJ cord-009571-mygj2nd4 1825 47 I I NNP cord-009571-mygj2nd4 1825 48 , , , cord-009571-mygj2nd4 1825 49 proliferative proliferative JJ cord-009571-mygj2nd4 1825 50 vessels vessel NNS cord-009571-mygj2nd4 1825 51 1 1 CD cord-009571-mygj2nd4 1825 52 , , , cord-009571-mygj2nd4 1825 53 normal normal JJ cord-009571-mygj2nd4 1825 54 5 5 CD cord-009571-mygj2nd4 1825 55 . . . cord-009571-mygj2nd4 1826 1 Lung lung NN cord-009571-mygj2nd4 1826 2 tissue tissue NN cord-009571-mygj2nd4 1826 3 ( ( -LRB- cord-009571-mygj2nd4 1826 4 6 6 CD cord-009571-mygj2nd4 1826 5 ) ) -RRB- cord-009571-mygj2nd4 1826 6 revealed reveal VBD cord-009571-mygj2nd4 1826 7 : : : cord-009571-mygj2nd4 1826 8 vascular vascular JJ cord-009571-mygj2nd4 1826 9 proliferation proliferation NN cord-009571-mygj2nd4 1826 10 2 2 CD cord-009571-mygj2nd4 1826 11 , , , cord-009571-mygj2nd4 1826 12 vascular vascular JJ cord-009571-mygj2nd4 1826 13 medial medial JJ cord-009571-mygj2nd4 1826 14 hypertrophy hypertrophy NN cord-009571-mygj2nd4 1826 15 2 2 CD cord-009571-mygj2nd4 1826 16 , , , cord-009571-mygj2nd4 1826 17 and and CC cord-009571-mygj2nd4 1826 18 interstitial interstitial JJ cord-009571-mygj2nd4 1826 19 fibrosis fibrosis NN cord-009571-mygj2nd4 1826 20 3 3 CD cord-009571-mygj2nd4 1826 21 . . . cord-009571-mygj2nd4 1827 1 In in IN cord-009571-mygj2nd4 1827 2 MCTD MCTD NNP cord-009571-mygj2nd4 1827 3 , , , cord-009571-mygj2nd4 1827 4 children child NNS cord-009571-mygj2nd4 1827 5 and and CC cord-009571-mygj2nd4 1827 6 adults adult NNS cord-009571-mygj2nd4 1827 7 have have VBP cord-009571-mygj2nd4 1827 8 similar similar JJ cord-009571-mygj2nd4 1827 9 lesions lesion NNS cord-009571-mygj2nd4 1827 10 : : : cord-009571-mygj2nd4 1827 11 inflammatory inflammatory JJ cord-009571-mygj2nd4 1827 12 lesions lesion NNS cord-009571-mygj2nd4 1827 13 may may MD cord-009571-mygj2nd4 1827 14 predominate predominate VB cord-009571-mygj2nd4 1827 15 early early RB cord-009571-mygj2nd4 1827 16 , , , cord-009571-mygj2nd4 1827 17 but but CC cord-009571-mygj2nd4 1827 18 can can MD cord-009571-mygj2nd4 1827 19 occur occur VB cord-009571-mygj2nd4 1827 20 late late RB cord-009571-mygj2nd4 1827 21 . . . cord-009571-mygj2nd4 1828 1 Immunofluorescent Immunofluorescent NNP cord-009571-mygj2nd4 1828 2 data datum NNS cord-009571-mygj2nd4 1828 3 suggest suggest VBP cord-009571-mygj2nd4 1828 4 an an DT cord-009571-mygj2nd4 1828 5 immune immune JJ cord-009571-mygj2nd4 1828 6 basis basis NN cord-009571-mygj2nd4 1828 7 for for IN cord-009571-mygj2nd4 1828 8 injury injury NN cord-009571-mygj2nd4 1828 9 ; ; : cord-009571-mygj2nd4 1828 10 the the DT cord-009571-mygj2nd4 1828 11 late late JJ cord-009571-mygj2nd4 1828 12 predominance predominance NN cord-009571-mygj2nd4 1828 13 of of IN cord-009571-mygj2nd4 1828 14 proliferative proliferative JJ cord-009571-mygj2nd4 1828 15 vascular vascular JJ cord-009571-mygj2nd4 1828 16 lesions lesion NNS cord-009571-mygj2nd4 1828 17 suggests suggest VBZ cord-009571-mygj2nd4 1828 18 that that IN cord-009571-mygj2nd4 1828 19 vascular vascular JJ cord-009571-mygj2nd4 1828 20 sclerosis sclerosis NN cord-009571-mygj2nd4 1828 21 is be VBZ cord-009571-mygj2nd4 1828 22 a a DT cord-009571-mygj2nd4 1828 23 serious serious JJ cord-009571-mygj2nd4 1828 24 complication complication NN cord-009571-mygj2nd4 1828 25 . . . cord-009571-mygj2nd4 1829 1 The the DT cord-009571-mygj2nd4 1829 2 findings finding NNS cord-009571-mygj2nd4 1829 3 of of IN cord-009571-mygj2nd4 1829 4 many many JJ cord-009571-mygj2nd4 1829 5 significant significant JJ cord-009571-mygj2nd4 1829 6 histologic histologic JJ cord-009571-mygj2nd4 1829 7 lesions lesion NNS cord-009571-mygj2nd4 1829 8 , , , cord-009571-mygj2nd4 1829 9 without without IN cord-009571-mygj2nd4 1829 10 clinical clinical JJ cord-009571-mygj2nd4 1829 11 signs sign NNS cord-009571-mygj2nd4 1829 12 or or CC cord-009571-mygj2nd4 1829 13 symptoms symptom NNS cord-009571-mygj2nd4 1829 14 , , , cord-009571-mygj2nd4 1829 15 suggest suggest VBP cord-009571-mygj2nd4 1829 16 that that IN cord-009571-mygj2nd4 1829 17 features feature NNS cord-009571-mygj2nd4 1829 18 of of IN cord-009571-mygj2nd4 1829 19 this this DT cord-009571-mygj2nd4 1829 20 multi multi JJ cord-009571-mygj2nd4 1829 21 - - JJ cord-009571-mygj2nd4 1829 22 system system JJ cord-009571-mygj2nd4 1829 23 disease disease NN cord-009571-mygj2nd4 1829 24 evolve evolve VBP cord-009571-mygj2nd4 1829 25 slowly slowly RB cord-009571-mygj2nd4 1829 26 , , , cord-009571-mygj2nd4 1829 27 and and CC cord-009571-mygj2nd4 1829 28 that that IN cord-009571-mygj2nd4 1829 29 the the DT cord-009571-mygj2nd4 1829 30 full full JJ cord-009571-mygj2nd4 1829 31 spectrum spectrum NN cord-009571-mygj2nd4 1829 32 of of IN cord-009571-mygj2nd4 1829 33 MCTD MCTD NNP cord-009571-mygj2nd4 1829 34 is be VBZ cord-009571-mygj2nd4 1829 35 not not RB cord-009571-mygj2nd4 1829 36 yet yet RB cord-009571-mygj2nd4 1829 37 known know VBN cord-009571-mygj2nd4 1829 38 . . . cord-009571-mygj2nd4 1830 1 with with IN cord-009571-mygj2nd4 1830 2 RA RA NNP cord-009571-mygj2nd4 1830 3 and and CC cord-009571-mygj2nd4 1830 4 10 10 CD cord-009571-mygj2nd4 1830 5 normal normal JJ cord-009571-mygj2nd4 1830 6 subjects subject NNS cord-009571-mygj2nd4 1830 7 . . . cord-009571-mygj2nd4 1831 1 After after IN cord-009571-mygj2nd4 1831 2 isolation isolation NN cord-009571-mygj2nd4 1831 3 of of IN cord-009571-mygj2nd4 1831 4 the the DT cord-009571-mygj2nd4 1831 5 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 1831 6 by by IN cord-009571-mygj2nd4 1831 7 isopycnic isopycnic JJ cord-009571-mygj2nd4 1831 8 sedimentation sedimentation NN cord-009571-mygj2nd4 1831 9 , , , cord-009571-mygj2nd4 1831 10 the the DT cord-009571-mygj2nd4 1831 11 cells cell NNS cord-009571-mygj2nd4 1831 12 were be VBD cord-009571-mygj2nd4 1831 13 placed place VBN cord-009571-mygj2nd4 1831 14 in in IN cord-009571-mygj2nd4 1831 15 tissue tissue NN cord-009571-mygj2nd4 1831 16 culture culture NN cord-009571-mygj2nd4 1831 17 and and CC cord-009571-mygj2nd4 1831 18 half half NN cord-009571-mygj2nd4 1831 19 were be VBD cord-009571-mygj2nd4 1831 20 infected infect VBN cord-009571-mygj2nd4 1831 21 with with IN cord-009571-mygj2nd4 1831 22 EBV EBV NNP cord-009571-mygj2nd4 1831 23 . . . cord-009571-mygj2nd4 1832 1 Every every DT cord-009571-mygj2nd4 1832 2 6 6 CD cord-009571-mygj2nd4 1832 3 days day NNS cord-009571-mygj2nd4 1832 4 for for IN cord-009571-mygj2nd4 1832 5 1 1 CD cord-009571-mygj2nd4 1832 6 month month NN cord-009571-mygj2nd4 1832 7 the the DT cord-009571-mygj2nd4 1832 8 supernatant supernatant JJ cord-009571-mygj2nd4 1832 9 fluid fluid NN cord-009571-mygj2nd4 1832 10 was be VBD cord-009571-mygj2nd4 1832 11 removed remove VBN cord-009571-mygj2nd4 1832 12 from from IN cord-009571-mygj2nd4 1832 13 each each DT cord-009571-mygj2nd4 1832 14 culture culture NN cord-009571-mygj2nd4 1832 15 and and CC cord-009571-mygj2nd4 1832 16 fresh fresh JJ cord-009571-mygj2nd4 1832 17 medium medium NN cord-009571-mygj2nd4 1832 18 was be VBD cord-009571-mygj2nd4 1832 19 added add VBN cord-009571-mygj2nd4 1832 20 . . . cord-009571-mygj2nd4 1833 1 Total total JJ cord-009571-mygj2nd4 1833 2 IgM IgM NNP cord-009571-mygj2nd4 1833 3 and and CC cord-009571-mygj2nd4 1833 4 IgM IgM NNP cord-009571-mygj2nd4 1833 5 - - HYPH cord-009571-mygj2nd4 1833 6 RF RF NNP cord-009571-mygj2nd4 1833 7 secreted secrete VBD cord-009571-mygj2nd4 1833 8 into into IN cord-009571-mygj2nd4 1833 9 the the DT cord-009571-mygj2nd4 1833 10 supernatant supernatant NN cord-009571-mygj2nd4 1833 11 were be VBD cord-009571-mygj2nd4 1833 12 measured measure VBN cord-009571-mygj2nd4 1833 13 by by IN cord-009571-mygj2nd4 1833 14 solid solid JJ cord-009571-mygj2nd4 1833 15 phase phase NN cord-009571-mygj2nd4 1833 16 radioimmunoassay radioimmunoassay JJ cord-009571-mygj2nd4 1833 17 . . . cord-009571-mygj2nd4 1834 1 Independently independently RB cord-009571-mygj2nd4 1834 2 the the DT cord-009571-mygj2nd4 1834 3 cells cell NNS cord-009571-mygj2nd4 1834 4 were be VBD cord-009571-mygj2nd4 1834 5 examined examine VBN cord-009571-mygj2nd4 1834 6 for for IN cord-009571-mygj2nd4 1834 7 transformation transformation NN cord-009571-mygj2nd4 1834 8 and and CC cord-009571-mygj2nd4 1834 9 numerically numerically RB cord-009571-mygj2nd4 1834 10 graded grade VBN cord-009571-mygj2nd4 1834 11 . . . cord-009571-mygj2nd4 1835 1 All all DT cord-009571-mygj2nd4 1835 2 infected infected JJ cord-009571-mygj2nd4 1835 3 cultures culture NNS cord-009571-mygj2nd4 1835 4 produced produce VBD cord-009571-mygj2nd4 1835 5 IgM IgM NNP cord-009571-mygj2nd4 1835 6 - - HYPH cord-009571-mygj2nd4 1835 7 RF RF NNP cord-009571-mygj2nd4 1835 8 , , , cord-009571-mygj2nd4 1835 9 which which WDT cord-009571-mygj2nd4 1835 10 correlated correlate VBD cord-009571-mygj2nd4 1835 11 with with IN cord-009571-mygj2nd4 1835 12 a a DT cord-009571-mygj2nd4 1835 13 high high JJ cord-009571-mygj2nd4 1835 14 grade grade NN cord-009571-mygj2nd4 1835 15 of of IN cord-009571-mygj2nd4 1835 16 transformation transformation NN cord-009571-mygj2nd4 1835 17 . . . cord-009571-mygj2nd4 1836 1 The the DT cord-009571-mygj2nd4 1836 2 amount amount NN cord-009571-mygj2nd4 1836 3 of of IN cord-009571-mygj2nd4 1836 4 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1836 5 factor factor NN cord-009571-mygj2nd4 1836 6 ( ( -LRB- cord-009571-mygj2nd4 1836 7 RF RF NNP cord-009571-mygj2nd4 1836 8 ) ) -RRB- cord-009571-mygj2nd4 1836 9 produced produce VBN cord-009571-mygj2nd4 1836 10 by by IN cord-009571-mygj2nd4 1836 11 EBV EBV NNP cord-009571-mygj2nd4 1836 12 infected infect VBN cord-009571-mygj2nd4 1836 13 normal normal JJ cord-009571-mygj2nd4 1836 14 , , , cord-009571-mygj2nd4 1836 15 but but CC cord-009571-mygj2nd4 1836 16 not not RB cord-009571-mygj2nd4 1836 17 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 1836 18 , , , cord-009571-mygj2nd4 1836 19 lympho- lympho- NNP cord-009571-mygj2nd4 1836 20 _SP cord-009571-mygj2nd4 1837 1 The the DT cord-009571-mygj2nd4 1837 2 incubation incubation NN cord-009571-mygj2nd4 1837 3 of of IN cord-009571-mygj2nd4 1837 4 PMNs pmn NNS cord-009571-mygj2nd4 1837 5 with with IN cord-009571-mygj2nd4 1837 6 a a DT cord-009571-mygj2nd4 1837 7 chemotactic chemotactic JJ cord-009571-mygj2nd4 1837 8 factor factor NN cord-009571-mygj2nd4 1837 9 ( ( -LRB- cord-009571-mygj2nd4 1837 10 CF CF NNP cord-009571-mygj2nd4 1837 11 ) ) -RRB- cord-009571-mygj2nd4 1837 12 , , , cord-009571-mygj2nd4 1837 13 in in IN cord-009571-mygj2nd4 1837 14 the the DT cord-009571-mygj2nd4 1837 15 absence absence NN cord-009571-mygj2nd4 1837 16 of of IN cord-009571-mygj2nd4 1837 17 a a DT cord-009571-mygj2nd4 1837 18 gradient gradient NN cord-009571-mygj2nd4 1837 19 , , , cord-009571-mygj2nd4 1837 20 prevents prevent VBZ cord-009571-mygj2nd4 1837 21 the the DT cord-009571-mygj2nd4 1837 22 cells cell NNS cord-009571-mygj2nd4 1837 23 from from IN cord-009571-mygj2nd4 1837 24 responding respond VBG cord-009571-mygj2nd4 1837 25 with with IN cord-009571-mygj2nd4 1837 26 directional directional JJ cord-009571-mygj2nd4 1837 27 migration migration NN cord-009571-mygj2nd4 1837 28 when when WRB cord-009571-mygj2nd4 1837 29 , , , cord-009571-mygj2nd4 1837 30 after after IN cord-009571-mygj2nd4 1837 31 washing washing NN cord-009571-mygj2nd4 1837 32 , , , cord-009571-mygj2nd4 1837 33 they -PRON- PRP cord-009571-mygj2nd4 1837 34 are be VBP cord-009571-mygj2nd4 1837 35 challenged challenge VBN cord-009571-mygj2nd4 1837 36 with with IN cord-009571-mygj2nd4 1837 37 a a DT cord-009571-mygj2nd4 1837 38 gradient gradient NN cord-009571-mygj2nd4 1837 39 of of IN cord-009571-mygj2nd4 1837 40 the the DT cord-009571-mygj2nd4 1837 41 same same JJ cord-009571-mygj2nd4 1837 42 or or CC cord-009571-mygj2nd4 1837 43 a a DT cord-009571-mygj2nd4 1837 44 different different JJ cord-009571-mygj2nd4 1837 45 chemotactic chemotactic JJ cord-009571-mygj2nd4 1837 46 factor factor NN cord-009571-mygj2nd4 1837 47 ( ( -LRB- cord-009571-mygj2nd4 1837 48 deactivation deactivation NN cord-009571-mygj2nd4 1837 49 and and CC cord-009571-mygj2nd4 1837 50 cross cross NN cord-009571-mygj2nd4 1837 51 - - JJ cord-009571-mygj2nd4 1837 52 deactivation deactivation NN cord-009571-mygj2nd4 1837 53 ) ) -RRB- cord-009571-mygj2nd4 1837 54 . . . cord-009571-mygj2nd4 1838 1 Structurally structurally RB cord-009571-mygj2nd4 1838 2 unrelated unrelated JJ cord-009571-mygj2nd4 1838 3 CFs cf NNS cord-009571-mygj2nd4 1838 4 , , , cord-009571-mygj2nd4 1838 5 some some DT cord-009571-mygj2nd4 1838 6 shown show VBN cord-009571-mygj2nd4 1838 7 to to TO cord-009571-mygj2nd4 1838 8 bind bind VB cord-009571-mygj2nd4 1838 9 to to IN cord-009571-mygj2nd4 1838 10 distinct distinct JJ cord-009571-mygj2nd4 1838 11 cell cell NN cord-009571-mygj2nd4 1838 12 receptors receptor NNS cord-009571-mygj2nd4 1838 13 , , , cord-009571-mygj2nd4 1838 14 can can MD cord-009571-mygj2nd4 1838 15 cross cross VB cord-009571-mygj2nd4 1838 16 - - JJ cord-009571-mygj2nd4 1838 17 deactivate deactivate VB cord-009571-mygj2nd4 1838 18 , , , cord-009571-mygj2nd4 1838 19 which which WDT cord-009571-mygj2nd4 1838 20 suggests suggest VBZ cord-009571-mygj2nd4 1838 21 that that IN cord-009571-mygj2nd4 1838 22 deactivation deactivation NN cord-009571-mygj2nd4 1838 23 is be VBZ cord-009571-mygj2nd4 1838 24 not not RB cord-009571-mygj2nd4 1838 25 due due JJ cord-009571-mygj2nd4 1838 26 to to IN cord-009571-mygj2nd4 1838 27 receptor receptor NN cord-009571-mygj2nd4 1838 28 blockade blockade NN cord-009571-mygj2nd4 1838 29 . . . cord-009571-mygj2nd4 1839 1 We -PRON- PRP cord-009571-mygj2nd4 1839 2 propose propose VBP cord-009571-mygj2nd4 1839 3 that that IN cord-009571-mygj2nd4 1839 4 deactivation deactivation NN cord-009571-mygj2nd4 1839 5 is be VBZ cord-009571-mygj2nd4 1839 6 the the DT cord-009571-mygj2nd4 1839 7 result result NN cord-009571-mygj2nd4 1839 8 of of IN cord-009571-mygj2nd4 1839 9 generalized generalized JJ cord-009571-mygj2nd4 1839 10 microtubule microtubule JJ cord-009571-mygj2nd4 1839 11 assembly assembly NN cord-009571-mygj2nd4 1839 12 induced induce VBN cord-009571-mygj2nd4 1839 13 by by IN cord-009571-mygj2nd4 1839 14 C C NNP cord-009571-mygj2nd4 1839 15 F F NNP cord-009571-mygj2nd4 1839 16 incubated incubate VBD cord-009571-mygj2nd4 1839 17 with with IN cord-009571-mygj2nd4 1839 18 the the DT cord-009571-mygj2nd4 1839 19 cells cell NNS cord-009571-mygj2nd4 1839 20 in in IN cord-009571-mygj2nd4 1839 21 the the DT cord-009571-mygj2nd4 1839 22 absence absence NN cord-009571-mygj2nd4 1839 23 of of IN cord-009571-mygj2nd4 1839 24 a a DT cord-009571-mygj2nd4 1839 25 gradient gradient NN cord-009571-mygj2nd4 1839 26 , , , cord-009571-mygj2nd4 1839 27 thus thus RB cord-009571-mygj2nd4 1839 28 rendering render VBG cord-009571-mygj2nd4 1839 29 the the DT cord-009571-mygj2nd4 1839 30 cells cell NNS cord-009571-mygj2nd4 1839 31 incapable incapable JJ cord-009571-mygj2nd4 1839 32 of of IN cord-009571-mygj2nd4 1839 33 responding respond VBG cord-009571-mygj2nd4 1839 34 to to IN cord-009571-mygj2nd4 1839 35 a a DT cord-009571-mygj2nd4 1839 36 C c NN cord-009571-mygj2nd4 1839 37 F f NN cord-009571-mygj2nd4 1839 38 gradient gradient NN cord-009571-mygj2nd4 1839 39 with with IN cord-009571-mygj2nd4 1839 40 distinctive distinctive JJ cord-009571-mygj2nd4 1839 41 localized localized JJ cord-009571-mygj2nd4 1839 42 assembly assembly NN cord-009571-mygj2nd4 1839 43 , , , cord-009571-mygj2nd4 1839 44 a a DT cord-009571-mygj2nd4 1839 45 proposed propose VBN cord-009571-mygj2nd4 1839 46 requirement requirement NN cord-009571-mygj2nd4 1839 47 of of IN cord-009571-mygj2nd4 1839 48 normal normal JJ cord-009571-mygj2nd4 1839 49 chemotaxis chemotaxis NN cord-009571-mygj2nd4 1839 50 . . . cord-009571-mygj2nd4 1840 1 If if IN cord-009571-mygj2nd4 1840 2 this this DT cord-009571-mygj2nd4 1840 3 scheme scheme NN cord-009571-mygj2nd4 1840 4 is be VBZ cord-009571-mygj2nd4 1840 5 correct correct JJ cord-009571-mygj2nd4 1840 6 , , , cord-009571-mygj2nd4 1840 7 the the DT cord-009571-mygj2nd4 1840 8 simultaneous simultaneous JJ cord-009571-mygj2nd4 1840 9 preincubation preincubation NN cord-009571-mygj2nd4 1840 10 of of IN cord-009571-mygj2nd4 1840 11 PMNs pmn NNS cord-009571-mygj2nd4 1840 12 with with IN cord-009571-mygj2nd4 1840 13 suitable suitable JJ cord-009571-mygj2nd4 1840 14 concentrations concentration NNS cord-009571-mygj2nd4 1840 15 of of IN cord-009571-mygj2nd4 1840 16 colchicine colchicine NN cord-009571-mygj2nd4 1840 17 , , , cord-009571-mygj2nd4 1840 18 a a DT cord-009571-mygj2nd4 1840 19 microtubule microtubule NN cord-009571-mygj2nd4 1840 20 disrupting disrupt VBG cord-009571-mygj2nd4 1840 21 agent agent NN cord-009571-mygj2nd4 1840 22 , , , cord-009571-mygj2nd4 1840 23 and and CC cord-009571-mygj2nd4 1840 24 a a DT cord-009571-mygj2nd4 1840 25 C c NN cord-009571-mygj2nd4 1840 26 F f NN cord-009571-mygj2nd4 1840 27 should should MD cord-009571-mygj2nd4 1840 28 protect protect VB cord-009571-mygj2nd4 1840 29 the the DT cord-009571-mygj2nd4 1840 30 cell cell NN cord-009571-mygj2nd4 1840 31 against against IN cord-009571-mygj2nd4 1840 32 deactivation deactivation NN cord-009571-mygj2nd4 1840 33 and and CC cord-009571-mygj2nd4 1840 34 colchicine colchicine NN cord-009571-mygj2nd4 1840 35 - - HYPH cord-009571-mygj2nd4 1840 36 induced induce VBN cord-009571-mygj2nd4 1840 37 suppression suppression NN cord-009571-mygj2nd4 1840 38 of of IN cord-009571-mygj2nd4 1840 39 chemotaxis chemotaxis NN cord-009571-mygj2nd4 1840 40 . . . cord-009571-mygj2nd4 1841 1 Human human JJ cord-009571-mygj2nd4 1841 2 neutrophils neutrophil NNS cord-009571-mygj2nd4 1841 3 were be VBD cord-009571-mygj2nd4 1841 4 preincubated preincubate VBN cord-009571-mygj2nd4 1841 5 , , , cord-009571-mygj2nd4 1841 6 20 20 CD cord-009571-mygj2nd4 1841 7 ' ' POS cord-009571-mygj2nd4 1841 8 at at IN cord-009571-mygj2nd4 1841 9 37OC 37oc CD cord-009571-mygj2nd4 1841 10 , , , cord-009571-mygj2nd4 1841 11 with with IN cord-009571-mygj2nd4 1841 12 colchicine colchicine NNP cord-009571-mygj2nd4 1841 13 to to IN cord-009571-mygj2nd4 1841 14 10-'M 10-'m CD cord-009571-mygj2nd4 1841 15 ) ) -RRB- cord-009571-mygj2nd4 1841 16 ; ; : cord-009571-mygj2nd4 1841 17 the the DT cord-009571-mygj2nd4 1841 18 chemotactic chemotactic JJ cord-009571-mygj2nd4 1841 19 factors factor NNS cord-009571-mygj2nd4 1841 20 Gly Gly NNP cord-009571-mygj2nd4 1841 21 - - HYPH cord-009571-mygj2nd4 1841 22 His His NNP cord-009571-mygj2nd4 1841 23 - - HYPH cord-009571-mygj2nd4 1841 24 Gly Gly NNP cord-009571-mygj2nd4 1841 25 ( ( -LRB- cord-009571-mygj2nd4 1841 26 IOpg IOpg NNP cord-009571-mygj2nd4 1841 27 ) ) -RRB- cord-009571-mygj2nd4 1841 28 or or CC cord-009571-mygj2nd4 1841 29 crystalinduced crystalinduce VBN cord-009571-mygj2nd4 1841 30 chemotactic chemotactic JJ cord-009571-mygj2nd4 1841 31 factor factor NN cord-009571-mygj2nd4 1841 32 ( ( -LRB- cord-009571-mygj2nd4 1841 33 CCF CCF NNP cord-009571-mygj2nd4 1841 34 ) ) -RRB- cord-009571-mygj2nd4 1841 35 25pg 25pg NN cord-009571-mygj2nd4 1841 36 alone alone RB cord-009571-mygj2nd4 1841 37 ; ; : cord-009571-mygj2nd4 1841 38 colchicine colchicine NNP cord-009571-mygj2nd4 1841 39 and and CC cord-009571-mygj2nd4 1841 40 either either CC cord-009571-mygj2nd4 1841 41 chemotactis chemotactis JJ cord-009571-mygj2nd4 1841 42 factor factor NN cord-009571-mygj2nd4 1841 43 ; ; : cord-009571-mygj2nd4 1841 44 or or CC cord-009571-mygj2nd4 1841 45 Hanks Hanks NNP cord-009571-mygj2nd4 1841 46 . . . cord-009571-mygj2nd4 1842 1 Cells cell NNS cord-009571-mygj2nd4 1842 2 were be VBD cord-009571-mygj2nd4 1842 3 washed wash VBN cord-009571-mygj2nd4 1842 4 and and CC cord-009571-mygj2nd4 1842 5 tested test VBN cord-009571-mygj2nd4 1842 6 for for IN cord-009571-mygj2nd4 1842 7 chemotactic chemotactic JJ cord-009571-mygj2nd4 1842 8 response response NN cord-009571-mygj2nd4 1842 9 against against IN cord-009571-mygj2nd4 1842 10 the the DT cord-009571-mygj2nd4 1842 11 C C NNP cord-009571-mygj2nd4 1842 12 F F NNP cord-009571-mygj2nd4 1842 13 using use VBG cord-009571-mygj2nd4 1842 14 a a DT cord-009571-mygj2nd4 1842 15 radioassay radioassay NN cord-009571-mygj2nd4 1842 16 that that WDT cord-009571-mygj2nd4 1842 17 utilizes utilize VBZ cord-009571-mygj2nd4 1842 18 Y Y NNP cord-009571-mygj2nd4 1842 19 r r NN cord-009571-mygj2nd4 1842 20 labeled label VBD cord-009571-mygj2nd4 1842 21 neutrophils neutrophil NNS cord-009571-mygj2nd4 1842 22 . . . cord-009571-mygj2nd4 1843 1 Preincubation preincubation NN cord-009571-mygj2nd4 1843 2 of of IN cord-009571-mygj2nd4 1843 3 cells cell NNS cord-009571-mygj2nd4 1843 4 with with IN cord-009571-mygj2nd4 1843 5 either either CC cord-009571-mygj2nd4 1843 6 chemotactic chemotactic JJ cord-009571-mygj2nd4 1843 7 factor factor NN cord-009571-mygj2nd4 1843 8 or or CC cord-009571-mygj2nd4 1843 9 colchicine colchicine NN cord-009571-mygj2nd4 1843 10 alone alone RB cord-009571-mygj2nd4 1843 11 resulted result VBD cord-009571-mygj2nd4 1843 12 in in IN cord-009571-mygj2nd4 1843 13 a a DT cord-009571-mygj2nd4 1843 14 dose dose NN cord-009571-mygj2nd4 1843 15 - - HYPH cord-009571-mygj2nd4 1843 16 dependent dependent JJ cord-009571-mygj2nd4 1843 17 inhibition inhibition NN cord-009571-mygj2nd4 1843 18 of of IN cord-009571-mygj2nd4 1843 19 chemotaxis chemotaxis NN cord-009571-mygj2nd4 1843 20 . . . cord-009571-mygj2nd4 1844 1 When when WRB cord-009571-mygj2nd4 1844 2 cells cell NNS cord-009571-mygj2nd4 1844 3 were be VBD cord-009571-mygj2nd4 1844 4 preincubated preincubate VBN cord-009571-mygj2nd4 1844 5 with with IN cord-009571-mygj2nd4 1844 6 both both DT cord-009571-mygj2nd4 1844 7 chemotactic chemotactic JJ cord-009571-mygj2nd4 1844 8 factor factor NN cord-009571-mygj2nd4 1845 1 ( ( -LRB- cord-009571-mygj2nd4 1845 2 Gly Gly NNP cord-009571-mygj2nd4 1845 3 - - HYPH cord-009571-mygj2nd4 1845 4 His His NNP cord-009571-mygj2nd4 1845 5 - - HYPH cord-009571-mygj2nd4 1845 6 Gly Gly NNP cord-009571-mygj2nd4 1845 7 IOpg IOpg NNP cord-009571-mygj2nd4 1845 8 or or CC cord-009571-mygj2nd4 1845 9 CCF CCF NNP cord-009571-mygj2nd4 1845 10 20pg 20pg NN cord-009571-mygj2nd4 1845 11 ) ) -RRB- cord-009571-mygj2nd4 1845 12 and and CC cord-009571-mygj2nd4 1845 13 suitable suitable JJ cord-009571-mygj2nd4 1845 14 concentrations concentration NNS cord-009571-mygj2nd4 1845 15 of of IN cord-009571-mygj2nd4 1845 16 colchicine colchicine NNP cord-009571-mygj2nd4 1845 17 ( ( -LRB- cord-009571-mygj2nd4 1845 18 or or CC cord-009571-mygj2nd4 1845 19 IO IO NNP cord-009571-mygj2nd4 1845 20 - - HYPH cord-009571-mygj2nd4 1845 21 O O NNP cord-009571-mygj2nd4 1845 22 ) ) -RRB- cord-009571-mygj2nd4 1845 23 , , , cord-009571-mygj2nd4 1845 24 a a DT cord-009571-mygj2nd4 1845 25 reversal reversal NN cord-009571-mygj2nd4 1845 26 of of IN cord-009571-mygj2nd4 1845 27 the the DT cord-009571-mygj2nd4 1845 28 inhibition inhibition NN cord-009571-mygj2nd4 1845 29 of of IN cord-009571-mygj2nd4 1845 30 chemotaxis chemotaxis NN cord-009571-mygj2nd4 1845 31 was be VBD cord-009571-mygj2nd4 1845 32 noted note VBN cord-009571-mygj2nd4 1845 33 . . . cord-009571-mygj2nd4 1846 1 Deactivation deactivation NN cord-009571-mygj2nd4 1846 2 reappeared reappear VBD cord-009571-mygj2nd4 1846 3 when when WRB cord-009571-mygj2nd4 1846 4 the the DT cord-009571-mygj2nd4 1846 5 balanced balanced JJ cord-009571-mygj2nd4 1846 6 ratio ratio NN cord-009571-mygj2nd4 1846 7 between between IN cord-009571-mygj2nd4 1846 8 colchicine colchicine NNP cord-009571-mygj2nd4 1846 9 and and CC cord-009571-mygj2nd4 1846 10 C C NNP cord-009571-mygj2nd4 1846 11 F F NNP cord-009571-mygj2nd4 1846 12 was be VBD cord-009571-mygj2nd4 1846 13 altered alter VBN cord-009571-mygj2nd4 1846 14 . . . cord-009571-mygj2nd4 1847 1 Preincubation Preincubation NNP cord-009571-mygj2nd4 1847 2 of of IN cord-009571-mygj2nd4 1847 3 C c NN cord-009571-mygj2nd4 1847 4 C c NN cord-009571-mygj2nd4 1847 5 F F NNP cord-009571-mygj2nd4 1847 6 with with IN cord-009571-mygj2nd4 1847 7 colchicine colchicine NNP cord-009571-mygj2nd4 1847 8 had have VBD cord-009571-mygj2nd4 1847 9 no no DT cord-009571-mygj2nd4 1847 10 direct direct JJ cord-009571-mygj2nd4 1847 11 effect effect NN cord-009571-mygj2nd4 1847 12 on on IN cord-009571-mygj2nd4 1847 13 its -PRON- PRP$ cord-009571-mygj2nd4 1847 14 chemotactic chemotactic JJ cord-009571-mygj2nd4 1847 15 activity activity NN cord-009571-mygj2nd4 1847 16 , , , cord-009571-mygj2nd4 1847 17 and and CC cord-009571-mygj2nd4 1847 18 colchicine colchicine NNP cord-009571-mygj2nd4 1847 19 ( ( -LRB- cord-009571-mygj2nd4 1847 20 10 10 CD cord-009571-mygj2nd4 1847 21 - - SYM cord-009571-mygj2nd4 1847 22 6 6 CD cord-009571-mygj2nd4 1847 23 M M NNP cord-009571-mygj2nd4 1847 24 ) ) -RRB- cord-009571-mygj2nd4 1847 25 did do VBD cord-009571-mygj2nd4 1847 26 not not RB cord-009571-mygj2nd4 1847 27 alter alter VB cord-009571-mygj2nd4 1847 28 the the DT cord-009571-mygj2nd4 1847 29 specific specific JJ cord-009571-mygj2nd4 1847 30 binding binding NN cord-009571-mygj2nd4 1847 31 of of IN cord-009571-mygj2nd4 1847 32 radiolabeled radiolabeled JJ cord-009571-mygj2nd4 1847 33 C c NN cord-009571-mygj2nd4 1847 34 C c NN cord-009571-mygj2nd4 1847 35 F f NN cord-009571-mygj2nd4 1847 36 to to IN cord-009571-mygj2nd4 1847 37 neutrophils neutrophil NNS cord-009571-mygj2nd4 1847 38 . . . cord-009571-mygj2nd4 1848 1 Additionally additionally RB cord-009571-mygj2nd4 1848 2 , , , cord-009571-mygj2nd4 1848 3 both both DT cord-009571-mygj2nd4 1848 4 C c NN cord-009571-mygj2nd4 1848 5 C c NN cord-009571-mygj2nd4 1848 6 F F NNP cord-009571-mygj2nd4 1848 7 and and CC cord-009571-mygj2nd4 1848 8 Gly Gly NNP cord-009571-mygj2nd4 1848 9 - - HYPH cord-009571-mygj2nd4 1848 10 His His NNP cord-009571-mygj2nd4 1848 11 - - HYPH cord-009571-mygj2nd4 1848 12 Gly Gly NNP cord-009571-mygj2nd4 1848 13 induced induce VBN cord-009571-mygj2nd4 1848 14 microtubule microtubule NN cord-009571-mygj2nd4 1848 15 assembly assembly NN cord-009571-mygj2nd4 1848 16 by by IN cord-009571-mygj2nd4 1848 17 electron electron NN cord-009571-mygj2nd4 1848 18 microscopy microscopy NN cord-009571-mygj2nd4 1848 19 . . . cord-009571-mygj2nd4 1849 1 Functional functional JJ cord-009571-mygj2nd4 1849 2 evidence evidence NN cord-009571-mygj2nd4 1849 3 is be VBZ cord-009571-mygj2nd4 1849 4 presented present VBN cord-009571-mygj2nd4 1849 5 with with IN cord-009571-mygj2nd4 1849 6 two two CD cord-009571-mygj2nd4 1849 7 distinct distinct JJ cord-009571-mygj2nd4 1849 8 chemotactic chemotactic JJ cord-009571-mygj2nd4 1849 9 factors factor NNS cord-009571-mygj2nd4 1849 10 , , , cord-009571-mygj2nd4 1849 11 which which WDT cord-009571-mygj2nd4 1849 12 suggests suggest VBZ cord-009571-mygj2nd4 1849 13 that that IN cord-009571-mygj2nd4 1849 14 the the DT cord-009571-mygj2nd4 1849 15 basis basis NN cord-009571-mygj2nd4 1849 16 for for IN cord-009571-mygj2nd4 1849 17 deactivation deactivation NN cord-009571-mygj2nd4 1849 18 is be VBZ cord-009571-mygj2nd4 1849 19 overpolymerization overpolymerization NN cord-009571-mygj2nd4 1849 20 of of IN cord-009571-mygj2nd4 1849 21 microtubules microtubule NNS cord-009571-mygj2nd4 1849 22 that that WDT cord-009571-mygj2nd4 1849 23 prevents prevent VBZ cord-009571-mygj2nd4 1849 24 the the DT cord-009571-mygj2nd4 1849 25 PMNs pmn NNS cord-009571-mygj2nd4 1849 26 from from IN cord-009571-mygj2nd4 1849 27 responding respond VBG cord-009571-mygj2nd4 1849 28 to to IN cord-009571-mygj2nd4 1849 29 a a DT cord-009571-mygj2nd4 1849 30 chemotactic chemotactic JJ cord-009571-mygj2nd4 1849 31 gradient gradient NN cord-009571-mygj2nd4 1849 32 with with IN cord-009571-mygj2nd4 1849 33 directional directional JJ cord-009571-mygj2nd4 1849 34 migration migration NN cord-009571-mygj2nd4 1849 35 . . . cord-009571-mygj2nd4 1850 1 Fever fever NN cord-009571-mygj2nd4 1850 2 is be VBZ cord-009571-mygj2nd4 1850 3 a a DT cord-009571-mygj2nd4 1850 4 common common JJ cord-009571-mygj2nd4 1850 5 occurrence occurrence NN cord-009571-mygj2nd4 1850 6 and and CC cord-009571-mygj2nd4 1850 7 frequent frequent JJ cord-009571-mygj2nd4 1850 8 reason reason NN cord-009571-mygj2nd4 1850 9 for for IN cord-009571-mygj2nd4 1850 10 hospitalization hospitalization NN cord-009571-mygj2nd4 1850 11 of of IN cord-009571-mygj2nd4 1850 12 patients patient NNS cord-009571-mygj2nd4 1850 13 with with IN cord-009571-mygj2nd4 1850 14 systemic systemic JJ cord-009571-mygj2nd4 1850 15 lupus lupus NN cord-009571-mygj2nd4 1850 16 erythematosus erythematosus NN cord-009571-mygj2nd4 1850 17 ( ( -LRB- cord-009571-mygj2nd4 1850 18 SLE SLE NNP cord-009571-mygj2nd4 1850 19 ) ) -RRB- cord-009571-mygj2nd4 1850 20 . . . cord-009571-mygj2nd4 1851 1 To to TO cord-009571-mygj2nd4 1851 2 assess assess VB cord-009571-mygj2nd4 1851 3 the the DT cord-009571-mygj2nd4 1851 4 frequency frequency NN cord-009571-mygj2nd4 1851 5 , , , cord-009571-mygj2nd4 1851 6 causes cause NNS cord-009571-mygj2nd4 1851 7 , , , cord-009571-mygj2nd4 1851 8 and and CC cord-009571-mygj2nd4 1851 9 clinical clinical JJ cord-009571-mygj2nd4 1851 10 and and CC cord-009571-mygj2nd4 1851 11 laboratory laboratory NN cord-009571-mygj2nd4 1851 12 characteristics characteristic NNS cord-009571-mygj2nd4 1851 13 of of IN cord-009571-mygj2nd4 1851 14 febrile febrile JJ cord-009571-mygj2nd4 1851 15 episodes episode NNS cord-009571-mygj2nd4 1851 16 in in IN cord-009571-mygj2nd4 1851 17 hospitalized hospitalize VBN cord-009571-mygj2nd4 1851 18 patients patient NNS cord-009571-mygj2nd4 1851 19 with with IN cord-009571-mygj2nd4 1851 20 SLE SLE NNP cord-009571-mygj2nd4 1851 21 , , , cord-009571-mygj2nd4 1851 22 the the DT cord-009571-mygj2nd4 1851 23 medical medical JJ cord-009571-mygj2nd4 1851 24 records record NNS cord-009571-mygj2nd4 1851 25 of of IN cord-009571-mygj2nd4 1851 26 568 568 CD cord-009571-mygj2nd4 1851 27 admissions admission NNS cord-009571-mygj2nd4 1851 28 of of IN cord-009571-mygj2nd4 1851 29 160 160 CD cord-009571-mygj2nd4 1851 30 SLE SLE NNP cord-009571-mygj2nd4 1851 31 patients patient NNS cord-009571-mygj2nd4 1851 32 during during IN cord-009571-mygj2nd4 1851 33 the the DT cord-009571-mygj2nd4 1851 34 5 5 CD cord-009571-mygj2nd4 1851 35 year year NN cord-009571-mygj2nd4 1851 36 interval interval NN cord-009571-mygj2nd4 1851 37 1973 1973 CD cord-009571-mygj2nd4 1851 38 to to IN cord-009571-mygj2nd4 1851 39 1977 1977 CD cord-009571-mygj2nd4 1851 40 were be VBD cord-009571-mygj2nd4 1851 41 reviewed review VBN cord-009571-mygj2nd4 1851 42 . . . cord-009571-mygj2nd4 1852 1 Eighty eighty CD cord-009571-mygj2nd4 1852 2 - - HYPH cord-009571-mygj2nd4 1852 3 three three CD cord-009571-mygj2nd4 1852 4 febrile febrile JJ cord-009571-mygj2nd4 1852 5 episodes episode NNS cord-009571-mygj2nd4 1852 6 , , , cord-009571-mygj2nd4 1852 7 defined define VBN cord-009571-mygj2nd4 1852 8 as as IN cord-009571-mygj2nd4 1852 9 a a DT cord-009571-mygj2nd4 1852 10 n n CD cord-009571-mygj2nd4 1852 11 oral oral JJ cord-009571-mygj2nd4 1852 12 temperature temperature NN cord-009571-mygj2nd4 1852 13 238OC 238OC NNP cord-009571-mygj2nd4 1852 14 and and CC cord-009571-mygj2nd4 1852 15 one one CD cord-009571-mygj2nd4 1852 16 blood blood NN cord-009571-mygj2nd4 1852 17 culture culture NN cord-009571-mygj2nd4 1852 18 drawn draw VBN cord-009571-mygj2nd4 1852 19 for for IN cord-009571-mygj2nd4 1852 20 evaluation evaluation NN cord-009571-mygj2nd4 1852 21 of of IN cord-009571-mygj2nd4 1852 22 fever fever NN cord-009571-mygj2nd4 1852 23 , , , cord-009571-mygj2nd4 1852 24 occurred occur VBD cord-009571-mygj2nd4 1852 25 in in IN cord-009571-mygj2nd4 1852 26 63 63 CD cord-009571-mygj2nd4 1852 27 patients patient NNS cord-009571-mygj2nd4 1852 28 . . . cord-009571-mygj2nd4 1853 1 The the DT cord-009571-mygj2nd4 1853 2 febrile febrile JJ cord-009571-mygj2nd4 1853 3 episodes episode NNS cord-009571-mygj2nd4 1853 4 were be VBD cord-009571-mygj2nd4 1853 5 classified classify VBN cord-009571-mygj2nd4 1853 6 : : : cord-009571-mygj2nd4 1853 7 Group Group NNP cord-009571-mygj2nd4 1853 8 A A NNP cord-009571-mygj2nd4 1853 9 - - : cord-009571-mygj2nd4 1853 10 clinically clinically RB cord-009571-mygj2nd4 1853 11 active active JJ cord-009571-mygj2nd4 1853 12 SLE SLE NNP cord-009571-mygj2nd4 1853 13 only only RB cord-009571-mygj2nd4 1853 14 ( ( -LRB- cord-009571-mygj2nd4 1853 15 50 50 CD cord-009571-mygj2nd4 1853 16 ) ) -RRB- cord-009571-mygj2nd4 1853 17 . . . cord-009571-mygj2nd4 1854 1 Group Group NNP cord-009571-mygj2nd4 1854 2 B B NNP cord-009571-mygj2nd4 1854 3 - - HYPH cord-009571-mygj2nd4 1854 4 documented document VBN cord-009571-mygj2nd4 1854 5 infection infection NN cord-009571-mygj2nd4 1854 6 ( ( -LRB- cord-009571-mygj2nd4 1854 7 l9 l9 NNP cord-009571-mygj2nd4 1854 8 ) ) -RRB- cord-009571-mygj2nd4 1854 9 , , , cord-009571-mygj2nd4 1854 10 and and CC cord-009571-mygj2nd4 1854 11 Group Group NNP cord-009571-mygj2nd4 1854 12 C C NNP cord-009571-mygj2nd4 1854 13 - - HYPH cord-009571-mygj2nd4 1854 14 miscellaneous miscellaneous JJ cord-009571-mygj2nd4 1854 15 ( ( -LRB- cord-009571-mygj2nd4 1854 16 14 14 CD cord-009571-mygj2nd4 1854 17 ) ) -RRB- cord-009571-mygj2nd4 1854 18 . . . cord-009571-mygj2nd4 1855 1 Clinically clinically RB cord-009571-mygj2nd4 1855 2 active active JJ cord-009571-mygj2nd4 1855 3 SLE SLE NNP cord-009571-mygj2nd4 1855 4 accompanied accompany VBD cord-009571-mygj2nd4 1855 5 6 6 CD cord-009571-mygj2nd4 1855 6 episodes episode NNS cord-009571-mygj2nd4 1855 7 in in IN cord-009571-mygj2nd4 1855 8 B b NN cord-009571-mygj2nd4 1855 9 and and CC cord-009571-mygj2nd4 1855 10 2 2 CD cord-009571-mygj2nd4 1855 11 in in IN cord-009571-mygj2nd4 1855 12 C. C. NNP cord-009571-mygj2nd4 1855 13 Treatment Treatment NNP cord-009571-mygj2nd4 1856 1 a a DT cord-009571-mygj2nd4 1856 2 t t NN cord-009571-mygj2nd4 1856 3 the the DT cord-009571-mygj2nd4 1856 4 time time NN cord-009571-mygj2nd4 1856 5 fever fever NN cord-009571-mygj2nd4 1856 6 developed develop VBN cord-009571-mygj2nd4 1856 7 included include VBD cord-009571-mygj2nd4 1856 8 steroids steroid NNS cord-009571-mygj2nd4 1856 9 in in IN cord-009571-mygj2nd4 1856 10 64,84 64,84 CD cord-009571-mygj2nd4 1856 11 , , , cord-009571-mygj2nd4 1856 12 and and CC cord-009571-mygj2nd4 1856 13 100 100 CD cord-009571-mygj2nd4 1856 14 % % NN cord-009571-mygj2nd4 1856 15 and and CC cord-009571-mygj2nd4 1856 16 cytotoxic cytotoxic JJ cord-009571-mygj2nd4 1856 17 agents agent NNS cord-009571-mygj2nd4 1856 18 in in IN cord-009571-mygj2nd4 1856 19 16,32 16,32 CD cord-009571-mygj2nd4 1856 20 , , , cord-009571-mygj2nd4 1856 21 and and CC cord-009571-mygj2nd4 1856 22 50 50 CD cord-009571-mygj2nd4 1856 23 % % NN cord-009571-mygj2nd4 1856 24 of of IN cord-009571-mygj2nd4 1856 25 episodes episode NNS cord-009571-mygj2nd4 1856 26 in in IN cord-009571-mygj2nd4 1856 27 A a NN cord-009571-mygj2nd4 1856 28 , , , cord-009571-mygj2nd4 1856 29 B b NN cord-009571-mygj2nd4 1856 30 , , , cord-009571-mygj2nd4 1856 31 and and CC cord-009571-mygj2nd4 1856 32 C C NNP cord-009571-mygj2nd4 1856 33 , , , cord-009571-mygj2nd4 1856 34 respectively respectively RB cord-009571-mygj2nd4 1856 35 . . . cord-009571-mygj2nd4 1857 1 Infectious infectious JJ cord-009571-mygj2nd4 1857 2 causes cause NNS cord-009571-mygj2nd4 1857 3 of of IN cord-009571-mygj2nd4 1857 4 fever fever NN cord-009571-mygj2nd4 1857 5 were be VBD cord-009571-mygj2nd4 1857 6 bacterial bacterial JJ cord-009571-mygj2nd4 1857 7 septicemia septicemia NN cord-009571-mygj2nd4 1857 8 ( ( -LRB- cord-009571-mygj2nd4 1857 9 8) 8) NNP cord-009571-mygj2nd4 1857 10 , , , cord-009571-mygj2nd4 1857 11 localized localize VBN cord-009571-mygj2nd4 1857 12 bacterial bacterial JJ cord-009571-mygj2nd4 1857 13 infections infection NNS cord-009571-mygj2nd4 1857 14 ( ( -LRB- cord-009571-mygj2nd4 1857 15 7 7 CD cord-009571-mygj2nd4 1857 16 ) ) -RRB- cord-009571-mygj2nd4 1857 17 , , , cord-009571-mygj2nd4 1857 18 herpes herpes NNP cord-009571-mygj2nd4 1857 19 zoster zoster NN cord-009571-mygj2nd4 1857 20 ( ( -LRB- cord-009571-mygj2nd4 1857 21 3 3 CD cord-009571-mygj2nd4 1857 22 ) ) -RRB- cord-009571-mygj2nd4 1857 23 , , , cord-009571-mygj2nd4 1857 24 and and CC cord-009571-mygj2nd4 1857 25 miliary miliary JJ cord-009571-mygj2nd4 1857 26 tuberculosis tuberculosis NN cord-009571-mygj2nd4 1857 27 ( ( -LRB- cord-009571-mygj2nd4 1857 28 1 1 CD cord-009571-mygj2nd4 1857 29 ) ) -RRB- cord-009571-mygj2nd4 1857 30 . . . cord-009571-mygj2nd4 1858 1 Miscellaneous miscellaneous JJ cord-009571-mygj2nd4 1858 2 causes cause NNS cord-009571-mygj2nd4 1858 3 were be VBD cord-009571-mygj2nd4 1858 4 procedure procedure NN cord-009571-mygj2nd4 1858 5 - - HYPH cord-009571-mygj2nd4 1858 6 related relate VBN cord-009571-mygj2nd4 1858 7 fever fever NN cord-009571-mygj2nd4 1858 8 ( ( -LRB- cord-009571-mygj2nd4 1858 9 4 4 CD cord-009571-mygj2nd4 1858 10 ) ) -RRB- cord-009571-mygj2nd4 1858 11 . . . cord-009571-mygj2nd4 1859 1 drug drug NN cord-009571-mygj2nd4 1859 2 fever fever NN cord-009571-mygj2nd4 1859 3 ( ( -LRB- cord-009571-mygj2nd4 1859 4 3 3 CD cord-009571-mygj2nd4 1859 5 ) ) -RRB- cord-009571-mygj2nd4 1859 6 , , , cord-009571-mygj2nd4 1859 7 Addisonian addisonian JJ cord-009571-mygj2nd4 1859 8 crisis crisis NN cord-009571-mygj2nd4 1859 9 ( ( -LRB- cord-009571-mygj2nd4 1859 10 I i NN cord-009571-mygj2nd4 1859 11 ) ) -RRB- cord-009571-mygj2nd4 1859 12 , , , cord-009571-mygj2nd4 1859 13 myocardial myocardial JJ cord-009571-mygj2nd4 1859 14 infarction infarction NN cord-009571-mygj2nd4 1859 15 ( ( -LRB- cord-009571-mygj2nd4 1859 16 I i NN cord-009571-mygj2nd4 1859 17 ) ) -RRB- cord-009571-mygj2nd4 1859 18 , , , cord-009571-mygj2nd4 1859 19 and and CC cord-009571-mygj2nd4 1859 20 unidentified unidentified JJ cord-009571-mygj2nd4 1859 21 ( ( -LRB- cord-009571-mygj2nd4 1859 22 5 5 CD cord-009571-mygj2nd4 1859 23 ) ) -RRB- cord-009571-mygj2nd4 1859 24 . . . cord-009571-mygj2nd4 1860 1 The the DT cord-009571-mygj2nd4 1860 2 initial initial JJ cord-009571-mygj2nd4 1860 3 clinical clinical JJ cord-009571-mygj2nd4 1860 4 impression impression NN cord-009571-mygj2nd4 1860 5 was be VBD cord-009571-mygj2nd4 1860 6 correct correct JJ cord-009571-mygj2nd4 1860 7 in in IN cord-009571-mygj2nd4 1860 8 45 45 CD cord-009571-mygj2nd4 1860 9 of of IN cord-009571-mygj2nd4 1860 10 50 50 CD cord-009571-mygj2nd4 1860 11 infectious infectious JJ cord-009571-mygj2nd4 1860 12 episodes episode NNS cord-009571-mygj2nd4 1860 13 . . . cord-009571-mygj2nd4 1861 1 Two two CD cord-009571-mygj2nd4 1861 2 episodes episode NNS cord-009571-mygj2nd4 1861 3 of of IN cord-009571-mygj2nd4 1861 4 bacterial bacterial JJ cord-009571-mygj2nd4 1861 5 septicemia septicemia NN cord-009571-mygj2nd4 1861 6 were be VBD cord-009571-mygj2nd4 1861 7 unexpected unexpected JJ cord-009571-mygj2nd4 1861 8 ; ; : cord-009571-mygj2nd4 1861 9 one one CD cord-009571-mygj2nd4 1861 10 occurred occur VBD cord-009571-mygj2nd4 1861 11 in in IN cord-009571-mygj2nd4 1861 12 a a DT cord-009571-mygj2nd4 1861 13 patient patient NN cord-009571-mygj2nd4 1861 14 with with IN cord-009571-mygj2nd4 1861 15 concommitantly concommitantly RB cord-009571-mygj2nd4 1861 16 active active JJ cord-009571-mygj2nd4 1861 17 SLE SLE NNP cord-009571-mygj2nd4 1861 18 . . . cord-009571-mygj2nd4 1862 1 The the DT cord-009571-mygj2nd4 1862 2 clinical clinical JJ cord-009571-mygj2nd4 1862 3 impression impression NN cord-009571-mygj2nd4 1862 4 was be VBD cord-009571-mygj2nd4 1862 5 correct correct JJ cord-009571-mygj2nd4 1862 6 in in IN cord-009571-mygj2nd4 1862 7 47 47 CD cord-009571-mygj2nd4 1862 8 of of IN cord-009571-mygj2nd4 1862 9 51 51 CD cord-009571-mygj2nd4 1862 10 episodes episode NNS cord-009571-mygj2nd4 1862 11 in in IN cord-009571-mygj2nd4 1862 12 A a NN cord-009571-mygj2nd4 1862 13 ; ; : cord-009571-mygj2nd4 1862 14 infection infection NN cord-009571-mygj2nd4 1862 15 ( ( -LRB- cord-009571-mygj2nd4 1862 16 3 3 CD cord-009571-mygj2nd4 1862 17 ) ) -RRB- cord-009571-mygj2nd4 1862 18 , , , cord-009571-mygj2nd4 1862 19 acute acute JJ cord-009571-mygj2nd4 1862 20 appendicitis appendicitis NN cord-009571-mygj2nd4 1862 21 ( ( -LRB- cord-009571-mygj2nd4 1862 22 I i NN cord-009571-mygj2nd4 1862 23 ) ) -RRB- cord-009571-mygj2nd4 1862 24 , , , cord-009571-mygj2nd4 1862 25 and and CC cord-009571-mygj2nd4 1862 26 drug drug NN cord-009571-mygj2nd4 1862 27 fever fever NN cord-009571-mygj2nd4 1862 28 ( ( -LRB- cord-009571-mygj2nd4 1862 29 1 1 CD cord-009571-mygj2nd4 1862 30 ) ) -RRB- cord-009571-mygj2nd4 1862 31 were be VBD cord-009571-mygj2nd4 1862 32 suspected suspect VBN cord-009571-mygj2nd4 1862 33 in in IN cord-009571-mygj2nd4 1862 34 the the DT cord-009571-mygj2nd4 1862 35 others other NNS cord-009571-mygj2nd4 1862 36 . . . cord-009571-mygj2nd4 1863 1 Comparing compare VBG cord-009571-mygj2nd4 1863 2 A a NN cord-009571-mygj2nd4 1863 3 and and CC cord-009571-mygj2nd4 1863 4 B b NN cord-009571-mygj2nd4 1863 5 , , , cord-009571-mygj2nd4 1863 6 patients patient NNS cord-009571-mygj2nd4 1863 7 ' ' POS cord-009571-mygj2nd4 1863 8 age age NN cord-009571-mygj2nd4 1863 9 , , , cord-009571-mygj2nd4 1863 10 disease disease NN cord-009571-mygj2nd4 1863 11 duration duration NN cord-009571-mygj2nd4 1863 12 , , , cord-009571-mygj2nd4 1863 13 and and CC cord-009571-mygj2nd4 1863 14 fever fever NN cord-009571-mygj2nd4 1863 15 patterns pattern NNS cord-009571-mygj2nd4 1863 16 were be VBD cord-009571-mygj2nd4 1863 17 similar similar JJ cord-009571-mygj2nd4 1863 18 . . . cord-009571-mygj2nd4 1864 1 Shaking shake VBG cord-009571-mygj2nd4 1864 2 chills chill NNS cord-009571-mygj2nd4 1864 3 were be VBD cord-009571-mygj2nd4 1864 4 more more RBR cord-009571-mygj2nd4 1864 5 frequent frequent JJ cord-009571-mygj2nd4 1864 6 with with IN cord-009571-mygj2nd4 1864 7 infection infection NN cord-009571-mygj2nd4 1864 8 ( ( -LRB- cord-009571-mygj2nd4 1864 9 P p NN cord-009571-mygj2nd4 1864 10 < < XX cord-009571-mygj2nd4 1864 11 0.001 0.001 CD cord-009571-mygj2nd4 1864 12 ) ) -RRB- cord-009571-mygj2nd4 1864 13 but but CC cord-009571-mygj2nd4 1864 14 were be VBD cord-009571-mygj2nd4 1864 15 present present JJ cord-009571-mygj2nd4 1864 16 in in IN cord-009571-mygj2nd4 1864 17 28 28 CD cord-009571-mygj2nd4 1864 18 % % NN cord-009571-mygj2nd4 1864 19 of of IN cord-009571-mygj2nd4 1864 20 A. A. NNP cord-009571-mygj2nd4 1864 21 Laboratory Laboratory NNP cord-009571-mygj2nd4 1864 22 studies study NNS cord-009571-mygj2nd4 1864 23 helpful helpful JJ cord-009571-mygj2nd4 1864 24 in in IN cord-009571-mygj2nd4 1864 25 identifying identify VBG cord-009571-mygj2nd4 1864 26 patients patient NNS cord-009571-mygj2nd4 1864 27 with with IN cord-009571-mygj2nd4 1864 28 infection infection NN cord-009571-mygj2nd4 1865 1 were be VBD cord-009571-mygj2nd4 1865 2 leukocytosis leukocytosis NNP cord-009571-mygj2nd4 1865 3 > > XX cord-009571-mygj2nd4 1865 4 12 12 CD cord-009571-mygj2nd4 1865 5 X x NN cord-009571-mygj2nd4 1865 6 IP ip NN cord-009571-mygj2nd4 1865 7 / / SYM cord-009571-mygj2nd4 1865 8 mm mm NN cord-009571-mygj2nd4 1865 9 ( ( -LRB- cord-009571-mygj2nd4 1865 10 P p NN cord-009571-mygj2nd4 1865 11 < < XX cord-009571-mygj2nd4 1865 12 0.001 0.001 CD cord-009571-mygj2nd4 1865 13 ) ) -RRB- cord-009571-mygj2nd4 1865 14 , , , cord-009571-mygj2nd4 1865 15 neutrophilia neutrophilia NNP cord-009571-mygj2nd4 1865 16 > > XX cord-009571-mygj2nd4 1865 17 8 8 CD cord-009571-mygj2nd4 1865 18 X x NN cord-009571-mygj2nd4 1865 19 IP ip NN cord-009571-mygj2nd4 1865 20 / / SYM cord-009571-mygj2nd4 1865 21 mm mm NN cord-009571-mygj2nd4 1865 22 ( ( -LRB- cord-009571-mygj2nd4 1865 23 P p NN cord-009571-mygj2nd4 1865 24 < < XX cord-009571-mygj2nd4 1865 25 0.001 0.001 CD cord-009571-mygj2nd4 1865 26 ) ) -RRB- cord-009571-mygj2nd4 1865 27 and and CC cord-009571-mygj2nd4 1865 28 normal normal JJ cord-009571-mygj2nd4 1865 29 DNA dna NN cord-009571-mygj2nd4 1865 30 binding binding NN cord-009571-mygj2nd4 1865 31 ( ( -LRB- cord-009571-mygj2nd4 1865 32 P p NN cord-009571-mygj2nd4 1865 33 < < XX cord-009571-mygj2nd4 1865 34 0,001 0,001 CD cord-009571-mygj2nd4 1865 35 ) ) -RRB- cord-009571-mygj2nd4 1865 36 . . . cord-009571-mygj2nd4 1866 1 Four four CD cord-009571-mygj2nd4 1866 2 deaths death NNS cord-009571-mygj2nd4 1866 3 occurred occur VBD cord-009571-mygj2nd4 1866 4 despite despite IN cord-009571-mygj2nd4 1866 5 appropriate appropriate JJ cord-009571-mygj2nd4 1866 6 therapy therapy NN cord-009571-mygj2nd4 1866 7 : : : cord-009571-mygj2nd4 1866 8 1 1 CD cord-009571-mygj2nd4 1866 9 in in IN cord-009571-mygj2nd4 1866 10 A a NN cord-009571-mygj2nd4 1866 11 with with IN cord-009571-mygj2nd4 1866 12 necrotizing necrotize VBG cord-009571-mygj2nd4 1866 13 lupus lupus NN cord-009571-mygj2nd4 1866 14 pneumonitis pneumonitis NN cord-009571-mygj2nd4 1866 15 , , , cord-009571-mygj2nd4 1866 16 and and CC cord-009571-mygj2nd4 1866 17 3 3 CD cord-009571-mygj2nd4 1866 18 in in IN cord-009571-mygj2nd4 1866 19 B b NN cord-009571-mygj2nd4 1866 20 with with IN cord-009571-mygj2nd4 1866 21 gram gram NN cord-009571-mygj2nd4 1866 22 negative negative JJ cord-009571-mygj2nd4 1866 23 sepsis sepsis NN cord-009571-mygj2nd4 1866 24 , , , cord-009571-mygj2nd4 1866 25 2 2 CD cord-009571-mygj2nd4 1866 26 of of IN cord-009571-mygj2nd4 1866 27 whom whom WP cord-009571-mygj2nd4 1866 28 had have VBD cord-009571-mygj2nd4 1866 29 active active JJ cord-009571-mygj2nd4 1866 30 SLE SLE NNP cord-009571-mygj2nd4 1866 31 . . . cord-009571-mygj2nd4 1867 1 In in IN cord-009571-mygj2nd4 1867 2 summary summary NN cord-009571-mygj2nd4 1867 3 , , , cord-009571-mygj2nd4 1867 4 infection infection NN cord-009571-mygj2nd4 1867 5 accounted account VBD cord-009571-mygj2nd4 1867 6 for for IN cord-009571-mygj2nd4 1867 7 23 23 CD cord-009571-mygj2nd4 1867 8 % % NN cord-009571-mygj2nd4 1867 9 of of IN cord-009571-mygj2nd4 1867 10 febrile febrile JJ cord-009571-mygj2nd4 1867 11 episodes episode NNS cord-009571-mygj2nd4 1867 12 in in IN cord-009571-mygj2nd4 1867 13 hospitalized hospitalize VBN cord-009571-mygj2nd4 1867 14 patients patient NNS cord-009571-mygj2nd4 1867 15 with with IN cord-009571-mygj2nd4 1867 16 SLE SLE NNP cord-009571-mygj2nd4 1867 17 . . . cord-009571-mygj2nd4 1868 1 Bacterial bacterial JJ cord-009571-mygj2nd4 1868 2 septicemia septicemia NN cord-009571-mygj2nd4 1868 3 was be VBD cord-009571-mygj2nd4 1868 4 found find VBN cord-009571-mygj2nd4 1868 5 in in IN cord-009571-mygj2nd4 1868 6 11 11 CD cord-009571-mygj2nd4 1868 7 % % NN cord-009571-mygj2nd4 1868 8 and and CC cord-009571-mygj2nd4 1868 9 was be VBD cord-009571-mygj2nd4 1868 10 associated associate VBN cord-009571-mygj2nd4 1868 11 with with IN cord-009571-mygj2nd4 1868 12 a a DT cord-009571-mygj2nd4 1868 13 high high JJ cord-009571-mygj2nd4 1868 14 mortality mortality NN cord-009571-mygj2nd4 1868 15 . . . cord-009571-mygj2nd4 1869 1 The the DT cord-009571-mygj2nd4 1869 2 initial initial JJ cord-009571-mygj2nd4 1869 3 clinical clinical JJ cord-009571-mygj2nd4 1869 4 impression impression NN cord-009571-mygj2nd4 1869 5 was be VBD cord-009571-mygj2nd4 1869 6 usually usually RB cord-009571-mygj2nd4 1869 7 correct correct JJ cord-009571-mygj2nd4 1869 8 and and CC cord-009571-mygj2nd4 1869 9 the the DT cord-009571-mygj2nd4 1869 10 WBC WBC NNP cord-009571-mygj2nd4 1869 11 count count NN cord-009571-mygj2nd4 1869 12 , , , cord-009571-mygj2nd4 1869 13 absolute absolute JJ cord-009571-mygj2nd4 1869 14 neutrophil neutrophil NN cord-009571-mygj2nd4 1869 15 count count NN cord-009571-mygj2nd4 1869 16 , , , cord-009571-mygj2nd4 1869 17 and and CC cord-009571-mygj2nd4 1869 18 DNA dna NN cord-009571-mygj2nd4 1869 19 binding binding NN cord-009571-mygj2nd4 1869 20 were be VBD cord-009571-mygj2nd4 1869 21 helpful helpful JJ cord-009571-mygj2nd4 1869 22 in in IN cord-009571-mygj2nd4 1869 23 distinguishing distinguish VBG cord-009571-mygj2nd4 1869 24 between between IN cord-009571-mygj2nd4 1869 25 infection infection NN cord-009571-mygj2nd4 1869 26 and and CC cord-009571-mygj2nd4 1869 27 active active JJ cord-009571-mygj2nd4 1869 28 SLE SLE NNP cord-009571-mygj2nd4 1869 29 . . . cord-009571-mygj2nd4 1869 30 _SP cord-009571-mygj2nd4 1870 1 Renal renal JJ cord-009571-mygj2nd4 1870 2 involvement involvement NN cord-009571-mygj2nd4 1870 3 in in IN cord-009571-mygj2nd4 1870 4 progressive progressive JJ cord-009571-mygj2nd4 1870 5 systemic systemic JJ cord-009571-mygj2nd4 1870 6 sclerosis sclerosis NN cord-009571-mygj2nd4 1870 7 ( ( -LRB- cord-009571-mygj2nd4 1870 8 PSS PSS NNP cord-009571-mygj2nd4 1870 9 ) ) -RRB- cord-009571-mygj2nd4 1870 10 is be VBZ cord-009571-mygj2nd4 1870 11 the the DT cord-009571-mygj2nd4 1870 12 most most RBS cord-009571-mygj2nd4 1870 13 devastating devastating JJ cord-009571-mygj2nd4 1870 14 form form NN cord-009571-mygj2nd4 1870 15 of of IN cord-009571-mygj2nd4 1870 16 the the DT cord-009571-mygj2nd4 1870 17 disease disease NN cord-009571-mygj2nd4 1870 18 with with IN cord-009571-mygj2nd4 1870 19 one one CD cord-009571-mygj2nd4 1870 20 year year NN cord-009571-mygj2nd4 1870 21 mortality mortality NN cord-009571-mygj2nd4 1870 22 close close JJ cord-009571-mygj2nd4 1870 23 to to IN cord-009571-mygj2nd4 1870 24 100 100 CD cord-009571-mygj2nd4 1870 25 % % NN cord-009571-mygj2nd4 1870 26 unless unless IN cord-009571-mygj2nd4 1870 27 hemodialysis hemodialysis NN cord-009571-mygj2nd4 1870 28 or or CC cord-009571-mygj2nd4 1870 29 transplantation transplantation NN cord-009571-mygj2nd4 1870 30 is be VBZ cord-009571-mygj2nd4 1870 31 successful successful JJ cord-009571-mygj2nd4 1870 32 . . . cord-009571-mygj2nd4 1871 1 At at IN cord-009571-mygj2nd4 1871 2 present present JJ cord-009571-mygj2nd4 1871 3 , , , cord-009571-mygj2nd4 1871 4 there there EX cord-009571-mygj2nd4 1871 5 are be VBP cord-009571-mygj2nd4 1871 6 no no DT cord-009571-mygj2nd4 1871 7 reliable reliable JJ cord-009571-mygj2nd4 1871 8 predictive predictive JJ cord-009571-mygj2nd4 1871 9 factors factor NNS cord-009571-mygj2nd4 1871 10 which which WDT cord-009571-mygj2nd4 1871 11 allow allow VBP cord-009571-mygj2nd4 1871 12 us -PRON- PRP cord-009571-mygj2nd4 1871 13 to to TO cord-009571-mygj2nd4 1871 14 separate separate VB cord-009571-mygj2nd4 1871 15 those those DT cord-009571-mygj2nd4 1871 16 who who WP cord-009571-mygj2nd4 1871 17 will will MD cord-009571-mygj2nd4 1871 18 eventually eventually RB cord-009571-mygj2nd4 1871 19 develop develop VB cord-009571-mygj2nd4 1871 20 renal renal JJ cord-009571-mygj2nd4 1871 21 disease disease NN cord-009571-mygj2nd4 1871 22 from from IN cord-009571-mygj2nd4 1871 23 those those DT cord-009571-mygj2nd4 1871 24 who who WP cord-009571-mygj2nd4 1871 25 will will MD cord-009571-mygj2nd4 1871 26 not not RB cord-009571-mygj2nd4 1871 27 . . . cord-009571-mygj2nd4 1872 1 Because because IN cord-009571-mygj2nd4 1872 2 of of IN cord-009571-mygj2nd4 1872 3 this this DT cord-009571-mygj2nd4 1872 4 , , , cord-009571-mygj2nd4 1872 5 we -PRON- PRP cord-009571-mygj2nd4 1872 6 have have VBP cord-009571-mygj2nd4 1872 7 studied study VBN cord-009571-mygj2nd4 1872 8 9 9 CD cord-009571-mygj2nd4 1872 9 patients patient NNS cord-009571-mygj2nd4 1872 10 with with IN cord-009571-mygj2nd4 1872 11 PSS PSS NNP cord-009571-mygj2nd4 1872 12 who who WP cord-009571-mygj2nd4 1872 13 were be VBD cord-009571-mygj2nd4 1872 14 normotensive normotensive JJ cord-009571-mygj2nd4 1872 15 and and CC cord-009571-mygj2nd4 1872 16 had have VBD cord-009571-mygj2nd4 1872 17 normal normal JJ cord-009571-mygj2nd4 1872 18 renal renal JJ cord-009571-mygj2nd4 1872 19 function function NN cord-009571-mygj2nd4 1872 20 ( ( -LRB- cord-009571-mygj2nd4 1872 21 mean mean VB cord-009571-mygj2nd4 1872 22 serum serum NN cord-009571-mygj2nd4 1872 23 creatinine creatinine NN cord-009571-mygj2nd4 1872 24 0.89 0.89 CD cord-009571-mygj2nd4 1872 25 mg% mg% NNP cord-009571-mygj2nd4 1872 26 , , , cord-009571-mygj2nd4 1872 27 mean mean VB cord-009571-mygj2nd4 1873 1 creatinine creatinine NNP cord-009571-mygj2nd4 1873 2 clearance clearance NN cord-009571-mygj2nd4 1873 3 88 88 CD cord-009571-mygj2nd4 1873 4 cc cc NN cord-009571-mygj2nd4 1873 5 / / SYM cord-009571-mygj2nd4 1873 6 min min NN cord-009571-mygj2nd4 1874 1 , , , cord-009571-mygj2nd4 1874 2 mean mean VB cord-009571-mygj2nd4 1874 3 protein protein NN cord-009571-mygj2nd4 1874 4 excretion excretion NN cord-009571-mygj2nd4 1874 5 55 55 CD cord-009571-mygj2nd4 1874 6 mg/ mg/ NN cord-009571-mygj2nd4 1874 7 24 24 CD cord-009571-mygj2nd4 1874 8 hours hour NNS cord-009571-mygj2nd4 1874 9 ) ) -RRB- cord-009571-mygj2nd4 1874 10 and and CC cord-009571-mygj2nd4 1874 11 normal normal JJ cord-009571-mygj2nd4 1874 12 urinalysis urinalysis NN cord-009571-mygj2nd4 1874 13 . . . cord-009571-mygj2nd4 1875 1 Studies study NNS cord-009571-mygj2nd4 1875 2 included include VBD cord-009571-mygj2nd4 1875 3 percutaneous percutaneous JJ cord-009571-mygj2nd4 1875 4 renal renal JJ cord-009571-mygj2nd4 1875 5 biopsies biopsy NNS cord-009571-mygj2nd4 1875 6 , , , cord-009571-mygj2nd4 1875 7 evaluation evaluation NN cord-009571-mygj2nd4 1875 8 of of IN cord-009571-mygj2nd4 1875 9 the the DT cord-009571-mygj2nd4 1875 10 renin renin NN cord-009571-mygj2nd4 1875 11 - - HYPH cord-009571-mygj2nd4 1875 12 angiotensin angiotensin NN cord-009571-mygj2nd4 1875 13 system system NN cord-009571-mygj2nd4 1875 14 , , , cord-009571-mygj2nd4 1875 15 and and CC cord-009571-mygj2nd4 1875 16 a a DT cord-009571-mygj2nd4 1875 17 cold cold JJ cord-009571-mygj2nd4 1875 18 pressor pressor NN cord-009571-mygj2nd4 1875 19 test test NN cord-009571-mygj2nd4 1875 20 to to TO cord-009571-mygj2nd4 1875 21 try try VB cord-009571-mygj2nd4 1875 22 to to TO cord-009571-mygj2nd4 1875 23 determine determine VB cord-009571-mygj2nd4 1875 24 renal renal JJ cord-009571-mygj2nd4 1875 25 vascular vascular JJ cord-009571-mygj2nd4 1875 26 reactivity reactivity NN cord-009571-mygj2nd4 1875 27 . . . cord-009571-mygj2nd4 1876 1 Five five CD cord-009571-mygj2nd4 1876 2 of of IN cord-009571-mygj2nd4 1876 3 9 9 CD cord-009571-mygj2nd4 1876 4 renal renal JJ cord-009571-mygj2nd4 1876 5 biopsies biopsy NNS cord-009571-mygj2nd4 1876 6 demonstrated demonstrate VBD cord-009571-mygj2nd4 1876 7 distinct distinct JJ cord-009571-mygj2nd4 1876 8 vascular vascular JJ cord-009571-mygj2nd4 1876 9 lesions lesion NNS cord-009571-mygj2nd4 1876 10 on on IN cord-009571-mygj2nd4 1876 11 light light JJ cord-009571-mygj2nd4 1876 12 microscopy microscopy NNS cord-009571-mygj2nd4 1876 13 with with IN cord-009571-mygj2nd4 1876 14 intimal intimal JJ cord-009571-mygj2nd4 1876 15 fibrosis fibrosis NN cord-009571-mygj2nd4 1876 16 in in IN cord-009571-mygj2nd4 1876 17 4 4 CD cord-009571-mygj2nd4 1876 18 , , , cord-009571-mygj2nd4 1876 19 hyaline hyaline JJ cord-009571-mygj2nd4 1876 20 intimal intimal JJ cord-009571-mygj2nd4 1876 21 sclerosis sclerosis NN cord-009571-mygj2nd4 1876 22 in in IN cord-009571-mygj2nd4 1876 23 3 3 CD cord-009571-mygj2nd4 1876 24 , , , cord-009571-mygj2nd4 1876 25 and and CC cord-009571-mygj2nd4 1876 26 arteriolar arteriolar JJ cord-009571-mygj2nd4 1876 27 fibrinoid fibrinoid JJ cord-009571-mygj2nd4 1876 28 necrosis necrosis NN cord-009571-mygj2nd4 1876 29 in in IN cord-009571-mygj2nd4 1876 30 1 1 CD cord-009571-mygj2nd4 1876 31 . . . cord-009571-mygj2nd4 1877 1 Electron electron NN cord-009571-mygj2nd4 1877 2 microscopy microscopy NN cord-009571-mygj2nd4 1877 3 of of IN cord-009571-mygj2nd4 1877 4 the the DT cord-009571-mygj2nd4 1877 5 vessels vessel NNS cord-009571-mygj2nd4 1877 6 showed show VBD cord-009571-mygj2nd4 1877 7 changes change NNS cord-009571-mygj2nd4 1877 8 similar similar JJ cord-009571-mygj2nd4 1877 9 to to IN cord-009571-mygj2nd4 1877 10 those those DT cord-009571-mygj2nd4 1877 11 on on IN cord-009571-mygj2nd4 1877 12 light light JJ cord-009571-mygj2nd4 1877 13 microscopy microscopy NNS cord-009571-mygj2nd4 1877 14 . . . cord-009571-mygj2nd4 1878 1 In in IN cord-009571-mygj2nd4 1878 2 addition addition NN cord-009571-mygj2nd4 1878 3 , , , cord-009571-mygj2nd4 1878 4 wrinkling wrinkle VBG cord-009571-mygj2nd4 1878 5 of of IN cord-009571-mygj2nd4 1878 6 the the DT cord-009571-mygj2nd4 1878 7 glomerular glomerular JJ cord-009571-mygj2nd4 1878 8 basement basement NN cord-009571-mygj2nd4 1878 9 membrane membrane NN cord-009571-mygj2nd4 1878 10 ( ( -LRB- cord-009571-mygj2nd4 1878 11 GBM GBM NNP cord-009571-mygj2nd4 1878 12 ) ) -RRB- cord-009571-mygj2nd4 1878 13 with with IN cord-009571-mygj2nd4 1878 14 expansion expansion NN cord-009571-mygj2nd4 1878 15 of of IN cord-009571-mygj2nd4 1878 16 the the DT cord-009571-mygj2nd4 1878 17 mesangium mesangium NN cord-009571-mygj2nd4 1878 18 by by IN cord-009571-mygj2nd4 1878 19 GBM GBM NNP cord-009571-mygj2nd4 1878 20 - - HYPH cord-009571-mygj2nd4 1878 21 like like JJ cord-009571-mygj2nd4 1878 22 material material NN cord-009571-mygj2nd4 1878 23 was be VBD cord-009571-mygj2nd4 1878 24 seen see VBN cord-009571-mygj2nd4 1878 25 in in IN cord-009571-mygj2nd4 1878 26 8 8 CD cord-009571-mygj2nd4 1878 27 of of IN cord-009571-mygj2nd4 1878 28 9 9 CD cord-009571-mygj2nd4 1878 29 biopsies biopsy NNS cord-009571-mygj2nd4 1878 30 . . . cord-009571-mygj2nd4 1879 1 Although although IN cord-009571-mygj2nd4 1879 2 nonspecific nonspecific JJ cord-009571-mygj2nd4 1879 3 , , , cord-009571-mygj2nd4 1879 4 these these DT cord-009571-mygj2nd4 1879 5 changes change NNS cord-009571-mygj2nd4 1879 6 are be VBP cord-009571-mygj2nd4 1879 7 suggestive suggestive JJ cord-009571-mygj2nd4 1879 8 of of IN cord-009571-mygj2nd4 1879 9 ischemia ischemia NN cord-009571-mygj2nd4 1879 10 in in IN cord-009571-mygj2nd4 1879 11 the the DT cord-009571-mygj2nd4 1879 12 kidney kidney NN cord-009571-mygj2nd4 1879 13 and and CC cord-009571-mygj2nd4 1879 14 are be VBP cord-009571-mygj2nd4 1879 15 compatible compatible JJ cord-009571-mygj2nd4 1879 16 with with IN cord-009571-mygj2nd4 1879 17 the the DT cord-009571-mygj2nd4 1879 18 vascular vascular JJ cord-009571-mygj2nd4 1879 19 changes change NNS cord-009571-mygj2nd4 1879 20 of of IN cord-009571-mygj2nd4 1879 21 PSS PSS NNP cord-009571-mygj2nd4 1879 22 . . . cord-009571-mygj2nd4 1880 1 Immunofluorescence Immunofluorescence NNP cord-009571-mygj2nd4 1880 2 studies study NNS cord-009571-mygj2nd4 1880 3 revealed reveal VBD cord-009571-mygj2nd4 1880 4 C3 C3 NNP cord-009571-mygj2nd4 1880 5 in in IN cord-009571-mygj2nd4 1880 6 vessels vessel NNS cord-009571-mygj2nd4 1880 7 in in IN cord-009571-mygj2nd4 1880 8 all all DT cord-009571-mygj2nd4 1880 9 9 9 CD cord-009571-mygj2nd4 1880 10 biopsies biopsy NNS cord-009571-mygj2nd4 1880 11 . . . cord-009571-mygj2nd4 1881 1 Plasma plasma NN cord-009571-mygj2nd4 1881 2 renin renin NN cord-009571-mygj2nd4 1881 3 activity activity NN cord-009571-mygj2nd4 1881 4 ( ( -LRB- cord-009571-mygj2nd4 1881 5 PPA PPA NNP cord-009571-mygj2nd4 1881 6 ) ) -RRB- cord-009571-mygj2nd4 1881 7 was be VBD cord-009571-mygj2nd4 1881 8 performed perform VBN cord-009571-mygj2nd4 1881 9 in in IN cord-009571-mygj2nd4 1881 10 8 8 CD cord-009571-mygj2nd4 1881 11 of of IN cord-009571-mygj2nd4 1881 12 9 9 CD cord-009571-mygj2nd4 1881 13 patients patient NNS cord-009571-mygj2nd4 1881 14 . . . cord-009571-mygj2nd4 1882 1 Of of IN cord-009571-mygj2nd4 1882 2 the the DT cord-009571-mygj2nd4 1882 3 5 5 CD cord-009571-mygj2nd4 1882 4 patients patient NNS cord-009571-mygj2nd4 1882 5 with with IN cord-009571-mygj2nd4 1882 6 abnormal abnormal JJ cord-009571-mygj2nd4 1882 7 biopsies biopsy NNS cord-009571-mygj2nd4 1882 8 , , , cord-009571-mygj2nd4 1882 9 4 4 CD cord-009571-mygj2nd4 1882 10 had have VBD cord-009571-mygj2nd4 1882 11 elevated elevate VBN cord-009571-mygj2nd4 1882 12 plasma plasma NN cord-009571-mygj2nd4 1882 13 renins renin NNS cord-009571-mygj2nd4 1882 14 ( ( -LRB- cord-009571-mygj2nd4 1882 15 9.31 9.31 CD cord-009571-mygj2nd4 1882 16 ng ng NN cord-009571-mygj2nd4 1882 17 / / SYM cord-009571-mygj2nd4 1882 18 ml ml NN cord-009571-mygj2nd4 1882 19 / / SYM cord-009571-mygj2nd4 1882 20 hr hr NN cord-009571-mygj2nd4 1882 21 ) ) -RRB- cord-009571-mygj2nd4 1882 22 at at IN cord-009571-mygj2nd4 1882 23 the the DT cord-009571-mygj2nd4 1882 24 time time NN cord-009571-mygj2nd4 1882 25 of of IN cord-009571-mygj2nd4 1882 26 biopsy biopsy NN cord-009571-mygj2nd4 1882 27 and and CC cord-009571-mygj2nd4 1882 28 the the DT cord-009571-mygj2nd4 1882 29 fifth fifth JJ cord-009571-mygj2nd4 1882 30 patient patient NN cord-009571-mygj2nd4 1882 31 has have VBZ cord-009571-mygj2nd4 1882 32 subsequently subsequently RB cord-009571-mygj2nd4 1882 33 developed develop VBN cord-009571-mygj2nd4 1882 34 significant significant JJ cord-009571-mygj2nd4 1882 35 elevation elevation NN cord-009571-mygj2nd4 1882 36 . . . cord-009571-mygj2nd4 1883 1 The the DT cord-009571-mygj2nd4 1883 2 3 3 CD cord-009571-mygj2nd4 1883 3 patients patient NNS cord-009571-mygj2nd4 1883 4 with with IN cord-009571-mygj2nd4 1883 5 normal normal JJ cord-009571-mygj2nd4 1883 6 biopsies biopsy NNS cord-009571-mygj2nd4 1883 7 had have VBD cord-009571-mygj2nd4 1883 8 normal normal JJ cord-009571-mygj2nd4 1883 9 plasma plasma NN cord-009571-mygj2nd4 1883 10 renins renin NNS cord-009571-mygj2nd4 1883 11 ( ( -LRB- cord-009571-mygj2nd4 1883 12 2.38 2.38 CD cord-009571-mygj2nd4 1883 13 ng ng NNP cord-009571-mygj2nd4 1883 14 / / SYM cord-009571-mygj2nd4 1883 15 ml ml NN cord-009571-mygj2nd4 1883 16 / / SYM cord-009571-mygj2nd4 1883 17 hr hr NN cord-009571-mygj2nd4 1883 18 ) ) -RRB- cord-009571-mygj2nd4 1883 19 . . . cord-009571-mygj2nd4 1884 1 Cold cold JJ cord-009571-mygj2nd4 1884 2 pressor pressor NN cord-009571-mygj2nd4 1884 3 testing testing NN cord-009571-mygj2nd4 1884 4 with with IN cord-009571-mygj2nd4 1884 5 PRA PRA NNP cord-009571-mygj2nd4 1884 6 determination determination NN cord-009571-mygj2nd4 1884 7 resulted result VBD cord-009571-mygj2nd4 1884 8 in in IN cord-009571-mygj2nd4 1884 9 a a DT cord-009571-mygj2nd4 1884 10 mean mean NN cord-009571-mygj2nd4 1884 11 maximal maximal JJ cord-009571-mygj2nd4 1884 12 increase increase NN cord-009571-mygj2nd4 1884 13 of of IN cord-009571-mygj2nd4 1884 14 6.52 6.52 CD cord-009571-mygj2nd4 1884 15 ng/ ng/ NNP cord-009571-mygj2nd4 1884 16 ml ml NNP cord-009571-mygj2nd4 1884 17 / / SYM cord-009571-mygj2nd4 1884 18 hr hr NN cord-009571-mygj2nd4 1884 19 in in IN cord-009571-mygj2nd4 1884 20 those those DT cord-009571-mygj2nd4 1884 21 with with IN cord-009571-mygj2nd4 1884 22 abnormal abnormal JJ cord-009571-mygj2nd4 1884 23 biopsies biopsy NNS cord-009571-mygj2nd4 1884 24 , , , cord-009571-mygj2nd4 1884 25 0.4 0.4 CD cord-009571-mygj2nd4 1884 26 ng ng NN cord-009571-mygj2nd4 1884 27 / / SYM cord-009571-mygj2nd4 1884 28 ml ml NN cord-009571-mygj2nd4 1884 29 / / SYM cord-009571-mygj2nd4 1884 30 hr hr NN cord-009571-mygj2nd4 1884 31 in in IN cord-009571-mygj2nd4 1884 32 those those DT cord-009571-mygj2nd4 1884 33 with with IN cord-009571-mygj2nd4 1884 34 normal normal JJ cord-009571-mygj2nd4 1884 35 biopsies biopsy NNS cord-009571-mygj2nd4 1884 36 , , , cord-009571-mygj2nd4 1884 37 and and CC cord-009571-mygj2nd4 1884 38 0.19 0.19 CD cord-009571-mygj2nd4 1884 39 ng ng NNP cord-009571-mygj2nd4 1884 40 / / SYM cord-009571-mygj2nd4 1884 41 ml ml NN cord-009571-mygj2nd4 1884 42 / / SYM cord-009571-mygj2nd4 1884 43 hr hr NN cord-009571-mygj2nd4 1884 44 in in IN cord-009571-mygj2nd4 1884 45 6 6 CD cord-009571-mygj2nd4 1884 46 control control NN cord-009571-mygj2nd4 1884 47 subjects subject NNS cord-009571-mygj2nd4 1884 48 . . . cord-009571-mygj2nd4 1885 1 These these DT cord-009571-mygj2nd4 1885 2 findings finding NNS cord-009571-mygj2nd4 1885 3 indicate indicate VBP cord-009571-mygj2nd4 1885 4 that that IN cord-009571-mygj2nd4 1885 5 renal renal JJ cord-009571-mygj2nd4 1885 6 histologic histologic JJ cord-009571-mygj2nd4 1885 7 vascular vascular JJ cord-009571-mygj2nd4 1885 8 involvement involvement NN cord-009571-mygj2nd4 1885 9 may may MD cord-009571-mygj2nd4 1885 10 precede precede VB cord-009571-mygj2nd4 1885 11 the the DT cord-009571-mygj2nd4 1885 12 onset onset NN cord-009571-mygj2nd4 1885 13 of of IN cord-009571-mygj2nd4 1885 14 clinical clinical JJ cord-009571-mygj2nd4 1885 15 renal renal JJ cord-009571-mygj2nd4 1885 16 disease disease NN cord-009571-mygj2nd4 1885 17 in in IN cord-009571-mygj2nd4 1885 18 PSS PSS NNP cord-009571-mygj2nd4 1885 19 and and CC cord-009571-mygj2nd4 1885 20 correlates correlate VBZ cord-009571-mygj2nd4 1885 21 well well RB cord-009571-mygj2nd4 1885 22 with with IN cord-009571-mygj2nd4 1885 23 PRA PRA NNP cord-009571-mygj2nd4 1885 24 elevations elevation NNS cord-009571-mygj2nd4 1885 25 and and CC cord-009571-mygj2nd4 1885 26 increased increase VBN cord-009571-mygj2nd4 1885 27 responsiveness responsiveness NN cord-009571-mygj2nd4 1885 28 of of IN cord-009571-mygj2nd4 1885 29 the the DT cord-009571-mygj2nd4 1885 30 renal renal JJ cord-009571-mygj2nd4 1885 31 vasculature vasculature NN cord-009571-mygj2nd4 1885 32 . . . cord-009571-mygj2nd4 1886 1 Followup followup NN cord-009571-mygj2nd4 1886 2 of of IN cord-009571-mygj2nd4 1886 3 these these DT cord-009571-mygj2nd4 1886 4 patients patient NNS cord-009571-mygj2nd4 1886 5 will will MD cord-009571-mygj2nd4 1886 6 determine determine VB cord-009571-mygj2nd4 1886 7 the the DT cord-009571-mygj2nd4 1886 8 clinical clinical JJ cord-009571-mygj2nd4 1886 9 significance significance NN cord-009571-mygj2nd4 1886 10 of of IN cord-009571-mygj2nd4 1886 11 these these DT cord-009571-mygj2nd4 1886 12 findings finding NNS cord-009571-mygj2nd4 1886 13 . . . cord-009571-mygj2nd4 1887 1 Ninety ninety CD cord-009571-mygj2nd4 1887 2 - - HYPH cord-009571-mygj2nd4 1887 3 six six CD cord-009571-mygj2nd4 1887 4 patients patient NNS cord-009571-mygj2nd4 1887 5 with with IN cord-009571-mygj2nd4 1887 6 classic classic JJ cord-009571-mygj2nd4 1887 7 or or CC cord-009571-mygj2nd4 1887 8 definite definite JJ cord-009571-mygj2nd4 1887 9 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 1887 10 arthritis arthritis NN cord-009571-mygj2nd4 1887 11 were be VBD cord-009571-mygj2nd4 1887 12 consecutively consecutively RB cord-009571-mygj2nd4 1887 13 screened screen VBN cord-009571-mygj2nd4 1887 14 for for IN cord-009571-mygj2nd4 1887 15 the the DT cord-009571-mygj2nd4 1887 16 presence presence NN cord-009571-mygj2nd4 1887 17 of of IN cord-009571-mygj2nd4 1887 18 early early JJ cord-009571-mygj2nd4 1887 19 ocular ocular JJ cord-009571-mygj2nd4 1887 20 manifestation manifestation NN cord-009571-mygj2nd4 1887 21 of of IN cord-009571-mygj2nd4 1887 22 disease disease NN cord-009571-mygj2nd4 1887 23 . . . cord-009571-mygj2nd4 1888 1 Each each DT cord-009571-mygj2nd4 1888 2 patient patient NN cord-009571-mygj2nd4 1888 3 was be VBD cord-009571-mygj2nd4 1888 4 followed follow VBN cord-009571-mygj2nd4 1888 5 for for IN cord-009571-mygj2nd4 1888 6 an an DT cord-009571-mygj2nd4 1888 7 average average NN cord-009571-mygj2nd4 1888 8 of of IN cord-009571-mygj2nd4 1888 9 18.7 18.7 CD cord-009571-mygj2nd4 1888 10 months month NNS cord-009571-mygj2nd4 1888 11 and and CC cord-009571-mygj2nd4 1888 12 received receive VBD cord-009571-mygj2nd4 1888 13 an an DT cord-009571-mygj2nd4 1888 14 average average NN cord-009571-mygj2nd4 1888 15 of of IN cord-009571-mygj2nd4 1888 16 4 4 CD cord-009571-mygj2nd4 1888 17 ophthalmologic ophthalmologic JJ cord-009571-mygj2nd4 1888 18 exams exam NNS cord-009571-mygj2nd4 1888 19 at at IN cord-009571-mygj2nd4 1888 20 an an DT cord-009571-mygj2nd4 1888 21 average average NN cord-009571-mygj2nd4 1888 22 of of IN cord-009571-mygj2nd4 1888 23 6 6 CD cord-009571-mygj2nd4 1888 24 month month NN cord-009571-mygj2nd4 1888 25 intervals interval NNS cord-009571-mygj2nd4 1888 26 . . . cord-009571-mygj2nd4 1889 1 None none NN cord-009571-mygj2nd4 1889 2 of of IN cord-009571-mygj2nd4 1889 3 the the DT cord-009571-mygj2nd4 1889 4 patients patient NNS cord-009571-mygj2nd4 1889 5 demonstrated demonstrate VBD cord-009571-mygj2nd4 1889 6 ocular ocular JJ cord-009571-mygj2nd4 1889 7 lesions lesion NNS cord-009571-mygj2nd4 1889 8 definitely definitely RB cord-009571-mygj2nd4 1889 9 attributable attributable JJ cord-009571-mygj2nd4 1889 10 to to IN cord-009571-mygj2nd4 1889 11 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 1889 12 arthritis arthritis NN cord-009571-mygj2nd4 1889 13 . . . cord-009571-mygj2nd4 1890 1 Eighteen eighteen CD cord-009571-mygj2nd4 1890 2 patients patient NNS cord-009571-mygj2nd4 1890 3 developed develop VBD cord-009571-mygj2nd4 1890 4 new new JJ cord-009571-mygj2nd4 1890 5 ocular ocular JJ cord-009571-mygj2nd4 1890 6 pathology pathology NN cord-009571-mygj2nd4 1890 7 consisting consist VBG cord-009571-mygj2nd4 1890 8 of of IN cord-009571-mygj2nd4 1890 9 chronic chronic JJ cord-009571-mygj2nd4 1890 10 blepharitis blepharitis NN cord-009571-mygj2nd4 1890 11 , , , cord-009571-mygj2nd4 1890 12 chronic chronic JJ cord-009571-mygj2nd4 1890 13 iritis iritis NN cord-009571-mygj2nd4 1890 14 , , , cord-009571-mygj2nd4 1890 15 corneal corneal JJ cord-009571-mygj2nd4 1890 16 subepithelial subepithelial JJ cord-009571-mygj2nd4 1890 17 defects defect NNS cord-009571-mygj2nd4 1890 18 , , , cord-009571-mygj2nd4 1890 19 keratitic keratitic NN cord-009571-mygj2nd4 1890 20 precipitates precipitate VBZ cord-009571-mygj2nd4 1890 21 , , , cord-009571-mygj2nd4 1890 22 keratitis keratitis NN cord-009571-mygj2nd4 1890 23 , , , cord-009571-mygj2nd4 1890 24 corneal corneal JJ cord-009571-mygj2nd4 1890 25 abrasion abrasion NN cord-009571-mygj2nd4 1890 26 , , , cord-009571-mygj2nd4 1890 27 and and CC cord-009571-mygj2nd4 1890 28 abnormal abnormal JJ cord-009571-mygj2nd4 1890 29 tear tear JJ cord-009571-mygj2nd4 1890 30 film film NN cord-009571-mygj2nd4 1890 31 . . . cord-009571-mygj2nd4 1891 1 Twenty twenty CD cord-009571-mygj2nd4 1891 2 - - HYPH cord-009571-mygj2nd4 1891 3 one one CD cord-009571-mygj2nd4 1891 4 patients patient NNS cord-009571-mygj2nd4 1891 5 of of IN cord-009571-mygj2nd4 1891 6 this this DT cord-009571-mygj2nd4 1891 7 group group NN cord-009571-mygj2nd4 1891 8 and and CC cord-009571-mygj2nd4 1891 9 15 15 CD cord-009571-mygj2nd4 1891 10 normal normal JJ cord-009571-mygj2nd4 1891 11 adult adult NN cord-009571-mygj2nd4 1891 12 controls control NNS cord-009571-mygj2nd4 1891 13 were be VBD cord-009571-mygj2nd4 1891 14 screened screen VBN cord-009571-mygj2nd4 1891 15 for for IN cord-009571-mygj2nd4 1891 16 keratoconjunctivitis keratoconjunctivitis NNP cord-009571-mygj2nd4 1891 17 sicca sicca NNP cord-009571-mygj2nd4 1891 18 . . . cord-009571-mygj2nd4 1892 1 Slit slit JJ cord-009571-mygj2nd4 1892 2 lamp lamp NN cord-009571-mygj2nd4 1892 3 examination examination NN cord-009571-mygj2nd4 1892 4 , , , cord-009571-mygj2nd4 1892 5 rose rise VBD cord-009571-mygj2nd4 1892 6 bengal bengal NNP cord-009571-mygj2nd4 1892 7 staining staining NN cord-009571-mygj2nd4 1892 8 , , , cord-009571-mygj2nd4 1892 9 Shirmer Shirmer NNP cord-009571-mygj2nd4 1892 10 's 's POS cord-009571-mygj2nd4 1892 11 testing testing NN cord-009571-mygj2nd4 1892 12 , , , cord-009571-mygj2nd4 1892 13 and and CC cord-009571-mygj2nd4 1892 14 tear tear NN cord-009571-mygj2nd4 1892 15 lysozyme lysozyme NNS cord-009571-mygj2nd4 1892 16 concentration concentration NN cord-009571-mygj2nd4 1892 17 were be VBD cord-009571-mygj2nd4 1892 18 measured measure VBN cord-009571-mygj2nd4 1892 19 in in IN cord-009571-mygj2nd4 1892 20 each each DT cord-009571-mygj2nd4 1892 21 patient patient NN cord-009571-mygj2nd4 1892 22 . . . cord-009571-mygj2nd4 1893 1 Tear tear JJ cord-009571-mygj2nd4 1893 2 lysozyme lysozyme NN cord-009571-mygj2nd4 1893 3 concentration concentration NN cord-009571-mygj2nd4 1893 4 was be VBD cord-009571-mygj2nd4 1893 5 indirectly indirectly RB cord-009571-mygj2nd4 1893 6 determined determine VBN cord-009571-mygj2nd4 1893 7 spectrophotometrically spectrophotometrically RB cord-009571-mygj2nd4 1893 8 by by IN cord-009571-mygj2nd4 1893 9 measur measur JJ cord-009571-mygj2nd4 1893 10 - - HYPH cord-009571-mygj2nd4 1893 11 ing e VBG cord-009571-mygj2nd4 1893 12 lysis lysis NN cord-009571-mygj2nd4 1893 13 of of IN cord-009571-mygj2nd4 1893 14 the the DT cord-009571-mygj2nd4 1893 15 dried dry VBN cord-009571-mygj2nd4 1893 16 cell cell NN cord-009571-mygj2nd4 1893 17 walls wall NNS cord-009571-mygj2nd4 1893 18 of of IN cord-009571-mygj2nd4 1893 19 Micrococcus Micrococcus NNP cord-009571-mygj2nd4 1893 20 lysodeikticus lysodeikticus NN cord-009571-mygj2nd4 1893 21 . . . cord-009571-mygj2nd4 1894 1 Patients patient NNS cord-009571-mygj2nd4 1894 2 with with IN cord-009571-mygj2nd4 1894 3 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1894 4 arthritis arthritis NN cord-009571-mygj2nd4 1894 5 demonstrated demonstrate VBD cord-009571-mygj2nd4 1894 6 abnormal abnormal JJ cord-009571-mygj2nd4 1894 7 rose rose NNP cord-009571-mygj2nd4 1894 8 bengal bengal NNP cord-009571-mygj2nd4 1894 9 staining staining NN cord-009571-mygj2nd4 1894 10 ( ( -LRB- cord-009571-mygj2nd4 1894 11 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 1894 12 arthritis arthritis NN cord-009571-mygj2nd4 1894 13 , , , cord-009571-mygj2nd4 1894 14 5 5 CD cord-009571-mygj2nd4 1894 15 patients patient NNS cord-009571-mygj2nd4 1894 16 ; ; : cord-009571-mygj2nd4 1894 17 control control NN cord-009571-mygj2nd4 1894 18 , , , cord-009571-mygj2nd4 1894 19 none none NN cord-009571-mygj2nd4 1894 20 ) ) -RRB- cord-009571-mygj2nd4 1894 21 , , , cord-009571-mygj2nd4 1894 22 significant significant JJ cord-009571-mygj2nd4 1894 23 decreased decrease VBD cord-009571-mygj2nd4 1894 24 tear tear JJ cord-009571-mygj2nd4 1894 25 production production NN cord-009571-mygj2nd4 1895 1 ( ( -LRB- cord-009571-mygj2nd4 1895 2 rheumatoid rheumatoid NNP cord-009571-mygj2nd4 1895 3 arthritis arthritis NN cord-009571-mygj2nd4 1895 4 , , , cord-009571-mygj2nd4 1895 5 14.5 14.5 CD cord-009571-mygj2nd4 1895 6 f f NN cord-009571-mygj2nd4 1895 7 1.9 1.9 CD cord-009571-mygj2nd4 1895 8 mm mm NNP cord-009571-mygj2nd4 1895 9 wetting wet VBG cord-009571-mygj2nd4 1895 10 Shirmer Shirmer NNP cord-009571-mygj2nd4 1895 11 strip strip NN cord-009571-mygj2nd4 1895 12 ; ; : cord-009571-mygj2nd4 1895 13 control control NN cord-009571-mygj2nd4 1895 14 , , , cord-009571-mygj2nd4 1895 15 24.0 24.0 CD cord-009571-mygj2nd4 1895 16 f f NNP cord-009571-mygj2nd4 1896 1 2.6 2.6 CD cord-009571-mygj2nd4 1896 2 mm mm CD cord-009571-mygj2nd4 1896 3 wetting wet VBG cord-009571-mygj2nd4 1896 4 Schirmer Schirmer NNP cord-009571-mygj2nd4 1896 5 strip strip NN cord-009571-mygj2nd4 1896 6 ) ) -RRB- cord-009571-mygj2nd4 1897 1 P p NN cord-009571-mygj2nd4 1897 2 < < XX cord-009571-mygj2nd4 1897 3 0.01 0.01 CD cord-009571-mygj2nd4 1897 4 , , , cord-009571-mygj2nd4 1897 5 and and CC cord-009571-mygj2nd4 1897 6 markedly markedly RB cord-009571-mygj2nd4 1897 7 increased increase VBN cord-009571-mygj2nd4 1897 8 tear tear JJ cord-009571-mygj2nd4 1897 9 lysozyme lysozyme NNS cord-009571-mygj2nd4 1897 10 concentration concentration NN cord-009571-mygj2nd4 1898 1 ( ( -LRB- cord-009571-mygj2nd4 1898 2 rheumatoid rheumatoid NNP cord-009571-mygj2nd4 1898 3 arthritis arthritis NN cord-009571-mygj2nd4 1898 4 , , , cord-009571-mygj2nd4 1898 5 41.0 41.0 CD cord-009571-mygj2nd4 1898 6 f f NN cord-009571-mygj2nd4 1898 7 4.4 4.4 CD cord-009571-mygj2nd4 1898 8 pg pg NNP cord-009571-mygj2nd4 1898 9 / / SYM cord-009571-mygj2nd4 1898 10 ml ml NN cord-009571-mygj2nd4 1898 11 ; ; : cord-009571-mygj2nd4 1898 12 controls control NNS cord-009571-mygj2nd4 1899 1 16.9 16.9 CD cord-009571-mygj2nd4 1899 2 f f NNP cord-009571-mygj2nd4 1899 3 3.8 3.8 CD cord-009571-mygj2nd4 1899 4 pg pg NNP cord-009571-mygj2nd4 1899 5 / / SYM cord-009571-mygj2nd4 1899 6 ml ml NN cord-009571-mygj2nd4 1899 7 ) ) -RRB- cord-009571-mygj2nd4 1899 8 P p NN cord-009571-mygj2nd4 1899 9 < < XX cord-009571-mygj2nd4 1899 10 0.01 0.01 CD cord-009571-mygj2nd4 1899 11 . . . cord-009571-mygj2nd4 1900 1 Thus thus RB cord-009571-mygj2nd4 1900 2 , , , cord-009571-mygj2nd4 1900 3 unlike unlike IN cord-009571-mygj2nd4 1900 4 patients patient NNS cord-009571-mygj2nd4 1900 5 with with IN cord-009571-mygj2nd4 1900 6 severe severe JJ cord-009571-mygj2nd4 1900 7 Sjagrens Sjagrens NNP cord-009571-mygj2nd4 1900 8 syndrome syndrome NN cord-009571-mygj2nd4 1900 9 who who WP cord-009571-mygj2nd4 1900 10 have have VBP cord-009571-mygj2nd4 1900 11 low low JJ cord-009571-mygj2nd4 1900 12 tear tear NN cord-009571-mygj2nd4 1900 13 lysozyme lysozyme NNS cord-009571-mygj2nd4 1900 14 concentrations concentration NNS cord-009571-mygj2nd4 1900 15 , , , cord-009571-mygj2nd4 1900 16 patients patient NNS cord-009571-mygj2nd4 1900 17 with with IN cord-009571-mygj2nd4 1900 18 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1900 19 arthritis arthritis NN cord-009571-mygj2nd4 1900 20 demonstrate demonstrate VBP cord-009571-mygj2nd4 1900 21 significant significant JJ cord-009571-mygj2nd4 1900 22 increases increase NNS cord-009571-mygj2nd4 1900 23 in in IN cord-009571-mygj2nd4 1900 24 tear tear JJ cord-009571-mygj2nd4 1900 25 lysozyme lysozyme NNS cord-009571-mygj2nd4 1900 26 levels level NNS cord-009571-mygj2nd4 1900 27 . . . cord-009571-mygj2nd4 1901 1 This this DT cord-009571-mygj2nd4 1901 2 new new JJ cord-009571-mygj2nd4 1901 3 finding finding NN cord-009571-mygj2nd4 1901 4 , , , cord-009571-mygj2nd4 1901 5 as as IN cord-009571-mygj2nd4 1901 6 yet yet RB cord-009571-mygj2nd4 1901 7 unexplained unexplained JJ cord-009571-mygj2nd4 1901 8 , , , cord-009571-mygj2nd4 1901 9 may may MD cord-009571-mygj2nd4 1901 10 represent represent VB cord-009571-mygj2nd4 1901 11 the the DT cord-009571-mygj2nd4 1901 12 earliest early JJS cord-009571-mygj2nd4 1901 13 lesion lesion NN cord-009571-mygj2nd4 1901 14 in in IN cord-009571-mygj2nd4 1901 15 the the DT cord-009571-mygj2nd4 1901 16 development development NN cord-009571-mygj2nd4 1901 17 of of IN cord-009571-mygj2nd4 1901 18 keratoconjunctivitis keratoconjunctivitis NNP cord-009571-mygj2nd4 1901 19 sicca sicca NNP cord-009571-mygj2nd4 1901 20 in in IN cord-009571-mygj2nd4 1901 21 patients patient NNS cord-009571-mygj2nd4 1901 22 with with IN cord-009571-mygj2nd4 1901 23 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1901 24 arthritis arthritis NN cord-009571-mygj2nd4 1901 25 . . . cord-009571-mygj2nd4 1902 1 NZB NZB NNP cord-009571-mygj2nd4 1902 2 / / SYM cord-009571-mygj2nd4 1902 3 NZW NZW NNP cord-009571-mygj2nd4 1902 4 mice mouse NNS cord-009571-mygj2nd4 1902 5 develop develop VBP cord-009571-mygj2nd4 1902 6 autoimmune autoimmune JJ cord-009571-mygj2nd4 1902 7 disease disease NN cord-009571-mygj2nd4 1903 1 similar similar JJ cord-009571-mygj2nd4 1903 2 t t NNP cord-009571-mygj2nd4 1903 3 o o NN cord-009571-mygj2nd4 1904 1 that that DT cord-009571-mygj2nd4 1904 2 of of IN cord-009571-mygj2nd4 1904 3 humans human NNS cord-009571-mygj2nd4 1904 4 with with IN cord-009571-mygj2nd4 1904 5 lupus lupus NN cord-009571-mygj2nd4 1904 6 systemic systemic JJ cord-009571-mygj2nd4 1904 7 erythematosus erythematosus NN cord-009571-mygj2nd4 1904 8 . . . cord-009571-mygj2nd4 1905 1 Treatment treatment NN cord-009571-mygj2nd4 1905 2 with with IN cord-009571-mygj2nd4 1905 3 cyclophosphamide cyclophosphamide NN cord-009571-mygj2nd4 1905 4 ( ( -LRB- cord-009571-mygj2nd4 1905 5 Cp cp NN cord-009571-mygj2nd4 1905 6 ) ) -RRB- cord-009571-mygj2nd4 1905 7 protects protect VBZ cord-009571-mygj2nd4 1905 8 against against IN cord-009571-mygj2nd4 1905 9 the the DT cord-009571-mygj2nd4 1905 10 disease disease NN cord-009571-mygj2nd4 1905 11 but but CC cord-009571-mygj2nd4 1905 12 often often RB cord-009571-mygj2nd4 1905 13 is be VBZ cord-009571-mygj2nd4 1905 14 associated associate VBN cord-009571-mygj2nd4 1905 15 with with IN cord-009571-mygj2nd4 1905 16 a a DT cord-009571-mygj2nd4 1905 17 high high JJ cord-009571-mygj2nd4 1905 18 incidence incidence NN cord-009571-mygj2nd4 1905 19 of of IN cord-009571-mygj2nd4 1905 20 tumors tumor NNS cord-009571-mygj2nd4 1905 21 . . . cord-009571-mygj2nd4 1906 1 Tumors tumor NNS cord-009571-mygj2nd4 1906 2 resulting result VBG cord-009571-mygj2nd4 1906 3 from from IN cord-009571-mygj2nd4 1906 4 direct direct JJ cord-009571-mygj2nd4 1906 5 chemical chemical JJ cord-009571-mygj2nd4 1906 6 carcinogenic carcinogenic JJ cord-009571-mygj2nd4 1906 7 activity activity NN cord-009571-mygj2nd4 1906 8 increase increase NN cord-009571-mygj2nd4 1906 9 with with IN cord-009571-mygj2nd4 1906 10 rising rise VBG cord-009571-mygj2nd4 1906 11 cumulative cumulative JJ cord-009571-mygj2nd4 1906 12 dose dose NN cord-009571-mygj2nd4 1906 13 and and CC cord-009571-mygj2nd4 1906 14 time time NN cord-009571-mygj2nd4 1906 15 after after IN cord-009571-mygj2nd4 1906 16 exposure exposure NN cord-009571-mygj2nd4 1906 17 and and CC cord-009571-mygj2nd4 1906 18 are be VBP cord-009571-mygj2nd4 1906 19 of of IN cord-009571-mygj2nd4 1906 20 diverse diverse JJ cord-009571-mygj2nd4 1906 21 types type NNS cord-009571-mygj2nd4 1906 22 . . . cord-009571-mygj2nd4 1907 1 Immunosuppression Immunosuppression NNP cord-009571-mygj2nd4 1907 2 itself -PRON- PRP cord-009571-mygj2nd4 1907 3 is be VBZ cord-009571-mygj2nd4 1907 4 reported report VBN cord-009571-mygj2nd4 1907 5 to to TO cord-009571-mygj2nd4 1907 6 facilitate facilitate VB cord-009571-mygj2nd4 1907 7 tumor tumor NN cord-009571-mygj2nd4 1907 8 growth growth NN cord-009571-mygj2nd4 1907 9 or or CC cord-009571-mygj2nd4 1907 10 , , , cord-009571-mygj2nd4 1907 11 perhaps perhaps RB cord-009571-mygj2nd4 1907 12 , , , cord-009571-mygj2nd4 1907 13 oncogene oncogene NN cord-009571-mygj2nd4 1907 14 expression expression NN cord-009571-mygj2nd4 1907 15 and and CC cord-009571-mygj2nd4 1907 16 has have VBZ cord-009571-mygj2nd4 1907 17 been be VBN cord-009571-mygj2nd4 1907 18 primarily primarily RB cord-009571-mygj2nd4 1907 19 associated associate VBN cord-009571-mygj2nd4 1907 20 with with IN cord-009571-mygj2nd4 1907 21 sustained sustained JJ cord-009571-mygj2nd4 1907 22 immunosuppression immunosuppression NN cord-009571-mygj2nd4 1907 23 , , , cord-009571-mygj2nd4 1907 24 predominantly predominantly RB cord-009571-mygj2nd4 1907 25 with with IN cord-009571-mygj2nd4 1907 26 tumors tumor NNS cord-009571-mygj2nd4 1907 27 of of IN cord-009571-mygj2nd4 1907 28 reticuloendothelial reticuloendothelial JJ cord-009571-mygj2nd4 1907 29 ( ( -LRB- cord-009571-mygj2nd4 1907 30 RE RE NNP cord-009571-mygj2nd4 1907 31 ) ) -RRB- cord-009571-mygj2nd4 1907 32 origin origin NN cord-009571-mygj2nd4 1907 33 . . . cord-009571-mygj2nd4 1908 1 We -PRON- PRP cord-009571-mygj2nd4 1908 2 compared compare VBD cord-009571-mygj2nd4 1908 3 tumor tumor NN cord-009571-mygj2nd4 1908 4 development development NN cord-009571-mygj2nd4 1908 5 in in IN cord-009571-mygj2nd4 1908 6 NZB NZB NNP cord-009571-mygj2nd4 1908 7 / / SYM cord-009571-mygj2nd4 1908 8 NZW NZW NNP cord-009571-mygj2nd4 1908 9 mice mouse NNS cord-009571-mygj2nd4 1908 10 given give VBN cord-009571-mygj2nd4 1908 11 different different JJ cord-009571-mygj2nd4 1908 12 Cp cp NN cord-009571-mygj2nd4 1908 13 regimens regimen NNS cord-009571-mygj2nd4 1908 14 ( ( -LRB- cord-009571-mygj2nd4 1908 15 see see VB cord-009571-mygj2nd4 1908 16 table table NN cord-009571-mygj2nd4 1908 17 ) ) -RRB- cord-009571-mygj2nd4 1908 18 . . . cord-009571-mygj2nd4 1909 1 Reticuloendothelial reticuloendothelial JJ cord-009571-mygj2nd4 1909 2 tumors tumor NNS cord-009571-mygj2nd4 1909 3 increased increase VBD cord-009571-mygj2nd4 1909 4 with with IN cord-009571-mygj2nd4 1909 5 daily daily JJ cord-009571-mygj2nd4 1909 6 dose dose NN cord-009571-mygj2nd4 1909 7 but but CC cord-009571-mygj2nd4 1909 8 did do VBD cord-009571-mygj2nd4 1909 9 not not RB cord-009571-mygj2nd4 1909 10 correlate correlate VB cord-009571-mygj2nd4 1909 11 with with IN cord-009571-mygj2nd4 1909 12 cumulative cumulative JJ cord-009571-mygj2nd4 1909 13 dose dose NN cord-009571-mygj2nd4 1909 14 or or CC cord-009571-mygj2nd4 1909 15 duration duration NN cord-009571-mygj2nd4 1909 16 of of IN cord-009571-mygj2nd4 1909 17 treatment treatment NN cord-009571-mygj2nd4 1909 18 . . . cord-009571-mygj2nd4 1910 1 Smaller small JJR cord-009571-mygj2nd4 1910 2 numbers number NNS cord-009571-mygj2nd4 1910 3 of of IN cord-009571-mygj2nd4 1910 4 other other JJ cord-009571-mygj2nd4 1910 5 ( ( -LRB- cord-009571-mygj2nd4 1910 6 non non JJ cord-009571-mygj2nd4 1910 7 - - JJ cord-009571-mygj2nd4 1910 8 RE re JJ cord-009571-mygj2nd4 1910 9 ) ) -RRB- cord-009571-mygj2nd4 1910 10 types type NNS cord-009571-mygj2nd4 1910 11 of of IN cord-009571-mygj2nd4 1910 12 neoplasms neoplasm NNS cord-009571-mygj2nd4 1910 13 occurred occur VBD cord-009571-mygj2nd4 1910 14 in in IN cord-009571-mygj2nd4 1910 15 all all DT cord-009571-mygj2nd4 1910 16 groups group NNS cord-009571-mygj2nd4 1910 17 . . . cord-009571-mygj2nd4 1911 1 Our -PRON- PRP$ cord-009571-mygj2nd4 1911 2 results result NNS cord-009571-mygj2nd4 1911 3 1 1 CD cord-009571-mygj2nd4 1911 4 ) ) -RRB- cord-009571-mygj2nd4 1911 5 suggest suggest VBP cord-009571-mygj2nd4 1911 6 that that IN cord-009571-mygj2nd4 1911 7 RE RE NNP cord-009571-mygj2nd4 1911 8 tumor tumor NN cord-009571-mygj2nd4 1911 9 development development NN cord-009571-mygj2nd4 1911 10 in in IN cord-009571-mygj2nd4 1911 11 autoimmune autoimmune JJ cord-009571-mygj2nd4 1911 12 disease disease NN cord-009571-mygj2nd4 1911 13 is be VBZ cord-009571-mygj2nd4 1911 14 more more RBR cord-009571-mygj2nd4 1911 15 dependent dependent JJ cord-009571-mygj2nd4 1911 16 on on IN cord-009571-mygj2nd4 1911 17 continuous continuous JJ cord-009571-mygj2nd4 1911 18 , , , cord-009571-mygj2nd4 1911 19 high high JJ cord-009571-mygj2nd4 1911 20 doses dose NNS cord-009571-mygj2nd4 1911 21 of of IN cord-009571-mygj2nd4 1911 22 cytotoxic cytotoxic JJ cord-009571-mygj2nd4 1911 23 drug drug NN cord-009571-mygj2nd4 1911 24 than than IN cord-009571-mygj2nd4 1911 25 on on IN cord-009571-mygj2nd4 1911 26 cumulative cumulative JJ cord-009571-mygj2nd4 1911 27 dose dose NN cord-009571-mygj2nd4 1911 28 or or CC cord-009571-mygj2nd4 1911 29 duration duration NN cord-009571-mygj2nd4 1911 30 of of IN cord-009571-mygj2nd4 1911 31 treatment treatment NN cord-009571-mygj2nd4 1911 32 and and CC cord-009571-mygj2nd4 1911 33 2 2 LS cord-009571-mygj2nd4 1911 34 ) ) -RRB- cord-009571-mygj2nd4 1911 35 are be VBP cord-009571-mygj2nd4 1911 36 compatible compatible JJ cord-009571-mygj2nd4 1911 37 with with IN cord-009571-mygj2nd4 1911 38 the the DT cord-009571-mygj2nd4 1911 39 possibility possibility NN cord-009571-mygj2nd4 1911 40 that that IN cord-009571-mygj2nd4 1911 41 RE re NN cord-009571-mygj2nd4 1911 42 tumors tumor NNS cord-009571-mygj2nd4 1911 43 result result VBP cord-009571-mygj2nd4 1911 44 from from IN cord-009571-mygj2nd4 1911 45 immunosuppression immunosuppression NN cord-009571-mygj2nd4 1911 46 or or CC cord-009571-mygj2nd4 1911 47 oncogene oncogene NN cord-009571-mygj2nd4 1911 48 expression expression NN cord-009571-mygj2nd4 1911 49 . . . cord-009571-mygj2nd4 1912 1 No no UH cord-009571-mygj2nd4 1912 2 . . . cord-009571-mygj2nd4 1912 3 _SP cord-009571-mygj2nd4 1913 1 The the DT cord-009571-mygj2nd4 1913 2 success success NN cord-009571-mygj2nd4 1913 3 of of IN cord-009571-mygj2nd4 1913 4 colchicine colchicine NN cord-009571-mygj2nd4 1913 5 in in IN cord-009571-mygj2nd4 1913 6 the the DT cord-009571-mygj2nd4 1913 7 treatment treatment NN cord-009571-mygj2nd4 1913 8 of of IN cord-009571-mygj2nd4 1913 9 acute acute JJ cord-009571-mygj2nd4 1913 10 gouty gouty JJ cord-009571-mygj2nd4 1913 11 arthritis arthritis NN cord-009571-mygj2nd4 1913 12 is be VBZ cord-009571-mygj2nd4 1913 13 well well RB cord-009571-mygj2nd4 1913 14 established establish VBN cord-009571-mygj2nd4 1913 15 . . . cord-009571-mygj2nd4 1914 1 However however RB cord-009571-mygj2nd4 1914 2 , , , cord-009571-mygj2nd4 1914 3 the the DT cord-009571-mygj2nd4 1914 4 usefulness usefulness NN cord-009571-mygj2nd4 1914 5 of of IN cord-009571-mygj2nd4 1914 6 this this DT cord-009571-mygj2nd4 1914 7 drug drug NN cord-009571-mygj2nd4 1914 8 in in IN cord-009571-mygj2nd4 1914 9 the the DT cord-009571-mygj2nd4 1914 10 therapy therapy NN cord-009571-mygj2nd4 1914 11 of of IN cord-009571-mygj2nd4 1914 12 the the DT cord-009571-mygj2nd4 1914 13 pseudogout pseudogout NNP cord-009571-mygj2nd4 1914 14 syndrome syndrome NN cord-009571-mygj2nd4 1914 15 has have VBZ cord-009571-mygj2nd4 1914 16 been be VBN cord-009571-mygj2nd4 1914 17 less less RBR cord-009571-mygj2nd4 1914 18 enthusiastically enthusiastically RB cord-009571-mygj2nd4 1914 19 regarded regard VBN cord-009571-mygj2nd4 1914 20 . . . cord-009571-mygj2nd4 1915 1 In in IN cord-009571-mygj2nd4 1915 2 general general JJ cord-009571-mygj2nd4 1915 3 , , , cord-009571-mygj2nd4 1915 4 assessments assessment NNS cord-009571-mygj2nd4 1915 5 of of IN cord-009571-mygj2nd4 1915 6 such such JJ cord-009571-mygj2nd4 1915 7 therapy therapy NN cord-009571-mygj2nd4 1915 8 refer refer VBP cord-009571-mygj2nd4 1915 9 to to IN cord-009571-mygj2nd4 1915 10 lower lower VB cord-009571-mygj2nd4 1915 11 success success NN cord-009571-mygj2nd4 1915 12 rates rate NNS cord-009571-mygj2nd4 1915 13 and and CC cord-009571-mygj2nd4 1915 14 somewhat somewhat RB cord-009571-mygj2nd4 1915 15 inconsistent inconsistent JJ cord-009571-mygj2nd4 1915 16 results result NNS cord-009571-mygj2nd4 1915 17 . . . cord-009571-mygj2nd4 1916 1 Nevertheless nevertheless RB cord-009571-mygj2nd4 1916 2 the the DT cord-009571-mygj2nd4 1916 3 use use NN cord-009571-mygj2nd4 1916 4 of of IN cord-009571-mygj2nd4 1916 5 other other JJ cord-009571-mygj2nd4 1916 6 antiinflammatory antiinflammatory JJ cord-009571-mygj2nd4 1916 7 drugs drug NNS cord-009571-mygj2nd4 1916 8 to to TO cord-009571-mygj2nd4 1916 9 treat treat VB cord-009571-mygj2nd4 1916 10 acute acute JJ cord-009571-mygj2nd4 1916 11 pseudogout pseudogout NN cord-009571-mygj2nd4 1916 12 is be VBZ cord-009571-mygj2nd4 1916 13 sometimes sometimes RB cord-009571-mygj2nd4 1916 14 militated militate VBN cord-009571-mygj2nd4 1916 15 against against IN cord-009571-mygj2nd4 1916 16 by by IN cord-009571-mygj2nd4 1916 17 the the DT cord-009571-mygj2nd4 1916 18 presence presence NN cord-009571-mygj2nd4 1916 19 of of IN cord-009571-mygj2nd4 1916 20 associated associate VBN cord-009571-mygj2nd4 1916 21 conditions condition NNS cord-009571-mygj2nd4 1916 22 commonly commonly RB cord-009571-mygj2nd4 1916 23 seen see VBN cord-009571-mygj2nd4 1916 24 in in IN cord-009571-mygj2nd4 1916 25 the the DT cord-009571-mygj2nd4 1916 26 age age NN cord-009571-mygj2nd4 1916 27 group group NN cord-009571-mygj2nd4 1916 28 of of IN cord-009571-mygj2nd4 1916 29 these these DT cord-009571-mygj2nd4 1916 30 patients patient NNS cord-009571-mygj2nd4 1916 31 , , , cord-009571-mygj2nd4 1916 32 including include VBG cord-009571-mygj2nd4 1916 33 congestive congestive JJ cord-009571-mygj2nd4 1916 34 heart heart NN cord-009571-mygj2nd4 1916 35 failure failure NN cord-009571-mygj2nd4 1916 36 , , , cord-009571-mygj2nd4 1916 37 gastrointestinal gastrointestinal JJ cord-009571-mygj2nd4 1916 38 disease disease NN cord-009571-mygj2nd4 1916 39 , , , cord-009571-mygj2nd4 1916 40 or or CC cord-009571-mygj2nd4 1916 41 neurological neurological JJ cord-009571-mygj2nd4 1916 42 deficits deficit NNS cord-009571-mygj2nd4 1916 43 . . . cord-009571-mygj2nd4 1917 1 We -PRON- PRP cord-009571-mygj2nd4 1917 2 have have VBP cord-009571-mygj2nd4 1917 3 treated treat VBN cord-009571-mygj2nd4 1917 4 7 7 CD cord-009571-mygj2nd4 1917 5 consecutive consecutive JJ cord-009571-mygj2nd4 1917 6 patients patient NNS cord-009571-mygj2nd4 1917 7 with with IN cord-009571-mygj2nd4 1917 8 the the DT cord-009571-mygj2nd4 1917 9 acute acute JJ cord-009571-mygj2nd4 1917 10 arthritis arthritis NN cord-009571-mygj2nd4 1917 11 of of IN cord-009571-mygj2nd4 1917 12 pseudogout pseudogout NN cord-009571-mygj2nd4 1917 13 with with IN cord-009571-mygj2nd4 1917 14 a a DT cord-009571-mygj2nd4 1917 15 standard standard JJ cord-009571-mygj2nd4 1917 16 regimen regimen NN cord-009571-mygj2nd4 1917 17 of of IN cord-009571-mygj2nd4 1917 18 colchicine colchicine NNP cord-009571-mygj2nd4 1917 19 by by IN cord-009571-mygj2nd4 1917 20 the the DT cord-009571-mygj2nd4 1917 21 intravenous intravenous JJ cord-009571-mygj2nd4 1917 22 ( ( -LRB- cord-009571-mygj2nd4 1917 23 IV IV NNP cord-009571-mygj2nd4 1917 24 ) ) -RRB- cord-009571-mygj2nd4 1917 25 route route NN cord-009571-mygj2nd4 1917 26 . . . cord-009571-mygj2nd4 1918 1 There there EX cord-009571-mygj2nd4 1918 2 were be VBD cord-009571-mygj2nd4 1918 3 4 4 CD cord-009571-mygj2nd4 1918 4 males male NNS cord-009571-mygj2nd4 1918 5 and and CC cord-009571-mygj2nd4 1918 6 3 3 CD cord-009571-mygj2nd4 1918 7 females female NNS cord-009571-mygj2nd4 1918 8 , , , cord-009571-mygj2nd4 1918 9 ages age NNS cord-009571-mygj2nd4 1918 10 56 56 CD cord-009571-mygj2nd4 1918 11 to to IN cord-009571-mygj2nd4 1918 12 88 88 CD cord-009571-mygj2nd4 1918 13 , , , cord-009571-mygj2nd4 1918 14 and and CC cord-009571-mygj2nd4 1918 15 all all DT cord-009571-mygj2nd4 1918 16 presented present VBN cord-009571-mygj2nd4 1918 17 with with IN cord-009571-mygj2nd4 1918 18 acute acute JJ cord-009571-mygj2nd4 1918 19 mono mono JJ cord-009571-mygj2nd4 1918 20 - - : cord-009571-mygj2nd4 1918 21 or or CC cord-009571-mygj2nd4 1918 22 oligoarticular oligoarticular JJ cord-009571-mygj2nd4 1918 23 arthritis arthritis NN cord-009571-mygj2nd4 1918 24 . . . cord-009571-mygj2nd4 1919 1 In in IN cord-009571-mygj2nd4 1919 2 all all DT cord-009571-mygj2nd4 1919 3 cases case NNS cord-009571-mygj2nd4 1919 4 typical typical JJ cord-009571-mygj2nd4 1919 5 calcium calcium NN cord-009571-mygj2nd4 1919 6 pyrophosphate pyrophosphate NN cord-009571-mygj2nd4 1919 7 dihydrate dihydrate NN cord-009571-mygj2nd4 1919 8 ( ( -LRB- cord-009571-mygj2nd4 1919 9 CPPD CPPD NNP cord-009571-mygj2nd4 1919 10 ) ) -RRB- cord-009571-mygj2nd4 1919 11 crystals crystal NNS cord-009571-mygj2nd4 1919 12 were be VBD cord-009571-mygj2nd4 1919 13 identified identify VBN cord-009571-mygj2nd4 1919 14 by by IN cord-009571-mygj2nd4 1919 15 red red RB cord-009571-mygj2nd4 1919 16 - - HYPH cord-009571-mygj2nd4 1919 17 compensated compensate VBN cord-009571-mygj2nd4 1919 18 polarized polarized JJ cord-009571-mygj2nd4 1919 19 light light JJ cord-009571-mygj2nd4 1919 20 microscopy microscopy NNS cord-009571-mygj2nd4 1919 21 of of IN cord-009571-mygj2nd4 1919 22 the the DT cord-009571-mygj2nd4 1919 23 synovial synovial JJ cord-009571-mygj2nd4 1919 24 fluid fluid NN cord-009571-mygj2nd4 1919 25 . . . cord-009571-mygj2nd4 1920 1 None none NN cord-009571-mygj2nd4 1920 2 of of IN cord-009571-mygj2nd4 1920 3 the the DT cord-009571-mygj2nd4 1920 4 patients patient NNS cord-009571-mygj2nd4 1920 5 had have VBD cord-009571-mygj2nd4 1920 6 elevated elevate VBN cord-009571-mygj2nd4 1920 7 serum serum NN cord-009571-mygj2nd4 1920 8 uric uric NN cord-009571-mygj2nd4 1920 9 acid acid NN cord-009571-mygj2nd4 1920 10 , , , cord-009571-mygj2nd4 1920 11 except except IN cord-009571-mygj2nd4 1920 12 1 1 CD cord-009571-mygj2nd4 1920 13 which which WDT cord-009571-mygj2nd4 1920 14 was be VBD cord-009571-mygj2nd4 1920 15 on on IN cord-009571-mygj2nd4 1920 16 diuretics diuretic NNS cord-009571-mygj2nd4 1920 17 , , , cord-009571-mygj2nd4 1920 18 and and CC cord-009571-mygj2nd4 1920 19 synovial synovial JJ cord-009571-mygj2nd4 1920 20 urate urate NN cord-009571-mygj2nd4 1920 21 crystals crystal NNS cord-009571-mygj2nd4 1920 22 were be VBD cord-009571-mygj2nd4 1920 23 absent absent JJ cord-009571-mygj2nd4 1920 24 . . . cord-009571-mygj2nd4 1921 1 Synovial synovial JJ cord-009571-mygj2nd4 1921 2 fluid fluid JJ cord-009571-mygj2nd4 1921 3 white white JJ cord-009571-mygj2nd4 1921 4 counts count NNS cord-009571-mygj2nd4 1921 5 varied vary VBN cord-009571-mygj2nd4 1921 6 from from IN cord-009571-mygj2nd4 1921 7 2600 2600 CD cord-009571-mygj2nd4 1921 8 to to IN cord-009571-mygj2nd4 1921 9 54000/ 54000/ CD cord-009571-mygj2nd4 1921 10 mma mma NNP cord-009571-mygj2nd4 1921 11 with with IN cord-009571-mygj2nd4 1921 12 70 70 CD cord-009571-mygj2nd4 1921 13 - - SYM cord-009571-mygj2nd4 1921 14 88 88 CD cord-009571-mygj2nd4 1921 15 % % NN cord-009571-mygj2nd4 1921 16 polymorphonuclear polymorphonuclear JJ cord-009571-mygj2nd4 1921 17 leukocytes leukocyte NNS cord-009571-mygj2nd4 1921 18 ; ; : cord-009571-mygj2nd4 1921 19 4 4 CD cord-009571-mygj2nd4 1921 20 of of IN cord-009571-mygj2nd4 1921 21 the the DT cord-009571-mygj2nd4 1921 22 7 7 CD cord-009571-mygj2nd4 1921 23 had have VBD cord-009571-mygj2nd4 1921 24 radiologic radiologic JJ cord-009571-mygj2nd4 1921 25 evidence evidence NN cord-009571-mygj2nd4 1921 26 of of IN cord-009571-mygj2nd4 1921 27 chondrocalcinosis chondrocalcinosis NN cord-009571-mygj2nd4 1921 28 . . . cord-009571-mygj2nd4 1922 1 All all DT cord-009571-mygj2nd4 1922 2 patients patient NNS cord-009571-mygj2nd4 1922 3 were be VBD cord-009571-mygj2nd4 1922 4 treated treat VBN cord-009571-mygj2nd4 1922 5 within within IN cord-009571-mygj2nd4 1922 6 54 54 CD cord-009571-mygj2nd4 1922 7 hours hour NNS cord-009571-mygj2nd4 1922 8 of of IN cord-009571-mygj2nd4 1922 9 the the DT cord-009571-mygj2nd4 1922 10 onset onset NN cord-009571-mygj2nd4 1922 11 of of IN cord-009571-mygj2nd4 1922 12 the the DT cord-009571-mygj2nd4 1922 13 acute acute JJ cord-009571-mygj2nd4 1922 14 arthritis arthritis NN cord-009571-mygj2nd4 1922 15 . . . cord-009571-mygj2nd4 1923 1 Colchicine Colchicine NNP cord-009571-mygj2nd4 1923 2 was be VBD cord-009571-mygj2nd4 1923 3 usually usually RB cord-009571-mygj2nd4 1923 4 given give VBN cord-009571-mygj2nd4 1923 5 at at IN cord-009571-mygj2nd4 1923 6 a a DT cord-009571-mygj2nd4 1923 7 dose dose NN cord-009571-mygj2nd4 1923 8 of of IN cord-009571-mygj2nd4 1923 9 2.0 2.0 CD cord-009571-mygj2nd4 1923 10 mgm mgm NNP cord-009571-mygj2nd4 1923 11 IV IV NNP cord-009571-mygj2nd4 1923 12 over over IN cord-009571-mygj2nd4 1923 13 a a DT cord-009571-mygj2nd4 1923 14 period period NN cord-009571-mygj2nd4 1923 15 of of IN cord-009571-mygj2nd4 1923 16 20 20 CD cord-009571-mygj2nd4 1923 17 minutes minute NNS cord-009571-mygj2nd4 1923 18 followed follow VBN cord-009571-mygj2nd4 1923 19 by by IN cord-009571-mygj2nd4 1923 20 0.5 0.5 CD cord-009571-mygj2nd4 1923 21 mg mg NNP cord-009571-mygj2nd4 1923 22 IV IV NNP cord-009571-mygj2nd4 1923 23 every every DT cord-009571-mygj2nd4 1923 24 6 6 CD cord-009571-mygj2nd4 1923 25 hours hour NNS cord-009571-mygj2nd4 1923 26 for for IN cord-009571-mygj2nd4 1923 27 the the DT cord-009571-mygj2nd4 1923 28 next next JJ cord-009571-mygj2nd4 1923 29 24 24 CD cord-009571-mygj2nd4 1923 30 - - SYM cord-009571-mygj2nd4 1923 31 48 48 CD cord-009571-mygj2nd4 1923 32 hours hour NNS cord-009571-mygj2nd4 1923 33 . . . cord-009571-mygj2nd4 1924 1 Total total JJ cord-009571-mygj2nd4 1924 2 IV IV NNP cord-009571-mygj2nd4 1924 3 colchicine colchicine NNP cord-009571-mygj2nd4 1924 4 dosage dosage NN cord-009571-mygj2nd4 1924 5 varied vary VBN cord-009571-mygj2nd4 1924 6 from from IN cord-009571-mygj2nd4 1924 7 4 4 CD cord-009571-mygj2nd4 1924 8 to to IN cord-009571-mygj2nd4 1924 9 7.5 7.5 CD cord-009571-mygj2nd4 1924 10 mgm mgm NNP cord-009571-mygj2nd4 1924 11 . . . cord-009571-mygj2nd4 1925 1 An an DT cord-009571-mygj2nd4 1925 2 excellent excellent JJ cord-009571-mygj2nd4 1925 3 response response NN cord-009571-mygj2nd4 1925 4 occurred occur VBD cord-009571-mygj2nd4 1925 5 in in IN cord-009571-mygj2nd4 1925 6 24 24 CD cord-009571-mygj2nd4 1925 7 - - SYM cord-009571-mygj2nd4 1925 8 36 36 CD cord-009571-mygj2nd4 1925 9 hours hour NNS cord-009571-mygj2nd4 1925 10 in in IN cord-009571-mygj2nd4 1925 11 5 5 CD cord-009571-mygj2nd4 1925 12 of of IN cord-009571-mygj2nd4 1925 13 7 7 CD cord-009571-mygj2nd4 1925 14 patients patient NNS cord-009571-mygj2nd4 1925 15 and and CC cord-009571-mygj2nd4 1925 16 in in IN cord-009571-mygj2nd4 1925 17 37 37 CD cord-009571-mygj2nd4 1925 18 - - SYM cord-009571-mygj2nd4 1925 19 48 48 CD cord-009571-mygj2nd4 1925 20 hours hour NNS cord-009571-mygj2nd4 1925 21 in in IN cord-009571-mygj2nd4 1925 22 the the DT cord-009571-mygj2nd4 1925 23 other other JJ cord-009571-mygj2nd4 1925 24 2 2 CD cord-009571-mygj2nd4 1925 25 , , , cord-009571-mygj2nd4 1925 26 with with IN cord-009571-mygj2nd4 1925 27 complete complete JJ cord-009571-mygj2nd4 1925 28 resolution resolution NN cord-009571-mygj2nd4 1925 29 of of IN cord-009571-mygj2nd4 1925 30 inflammation inflammation NN cord-009571-mygj2nd4 1925 31 in in IN cord-009571-mygj2nd4 1925 32 all all DT cord-009571-mygj2nd4 1925 33 7 7 CD cord-009571-mygj2nd4 1925 34 . . . cord-009571-mygj2nd4 1926 1 We -PRON- PRP cord-009571-mygj2nd4 1926 2 conclude conclude VBP cord-009571-mygj2nd4 1926 3 that that IN cord-009571-mygj2nd4 1926 4 1 1 CD cord-009571-mygj2nd4 1926 5 ) ) -RRB- cord-009571-mygj2nd4 1926 6 IV IV NNP cord-009571-mygj2nd4 1926 7 colchicine colchicine NNP cord-009571-mygj2nd4 1926 8 may may MD cord-009571-mygj2nd4 1926 9 provide provide VB cord-009571-mygj2nd4 1926 10 effective effective JJ cord-009571-mygj2nd4 1926 11 and and CC cord-009571-mygj2nd4 1926 12 consistent consistent JJ cord-009571-mygj2nd4 1926 13 therapy therapy NN cord-009571-mygj2nd4 1926 14 for for IN cord-009571-mygj2nd4 1926 15 the the DT cord-009571-mygj2nd4 1926 16 acute acute JJ cord-009571-mygj2nd4 1926 17 arthritis arthritis NN cord-009571-mygj2nd4 1926 18 of of IN cord-009571-mygj2nd4 1926 19 pseudogout pseudogout NN cord-009571-mygj2nd4 1926 20 ; ; : cord-009571-mygj2nd4 1926 21 and and CC cord-009571-mygj2nd4 1926 22 2 2 LS cord-009571-mygj2nd4 1926 23 ) ) -RRB- cord-009571-mygj2nd4 1926 24 because because IN cord-009571-mygj2nd4 1926 25 of of IN cord-009571-mygj2nd4 1926 26 this this DT cord-009571-mygj2nd4 1926 27 , , , cord-009571-mygj2nd4 1926 28 prompt prompt JJ cord-009571-mygj2nd4 1926 29 response response NN cord-009571-mygj2nd4 1926 30 of of IN cord-009571-mygj2nd4 1926 31 an an DT cord-009571-mygj2nd4 1926 32 acute acute JJ cord-009571-mygj2nd4 1926 33 arthritis arthritis NN cord-009571-mygj2nd4 1926 34 to to IN cord-009571-mygj2nd4 1926 35 IV IV NNP cord-009571-mygj2nd4 1926 36 colchicine colchicine NNP cord-009571-mygj2nd4 1926 37 remains remain VBZ cord-009571-mygj2nd4 1926 38 an an DT cord-009571-mygj2nd4 1926 39 insufficient insufficient JJ cord-009571-mygj2nd4 1926 40 clinical clinical JJ cord-009571-mygj2nd4 1926 41 criterion criterion NN cord-009571-mygj2nd4 1926 42 for for IN cord-009571-mygj2nd4 1926 43 the the DT cord-009571-mygj2nd4 1926 44 diagnosis diagnosis NN cord-009571-mygj2nd4 1926 45 of of IN cord-009571-mygj2nd4 1926 46 gout gout NN cord-009571-mygj2nd4 1926 47 . . . cord-009571-mygj2nd4 1927 1 The the DT cord-009571-mygj2nd4 1927 2 high high JJ cord-009571-mygj2nd4 1927 3 pyrophosphate pyrophosphate NN cord-009571-mygj2nd4 1927 4 ( ( -LRB- cord-009571-mygj2nd4 1927 5 PPi PPi NNS cord-009571-mygj2nd4 1927 6 ) ) -RRB- cord-009571-mygj2nd4 1927 7 concentrations concentration NNS cord-009571-mygj2nd4 1927 8 observed observe VBN cord-009571-mygj2nd4 1927 9 in in IN cord-009571-mygj2nd4 1927 10 osteoarthritis osteoarthritis NN cord-009571-mygj2nd4 1927 11 ( ( -LRB- cord-009571-mygj2nd4 1927 12 OA OA NNP cord-009571-mygj2nd4 1927 13 ) ) -RRB- cord-009571-mygj2nd4 1927 14 and and CC cord-009571-mygj2nd4 1927 15 chondrocalcinosis chondrocalcinosis NNP cord-009571-mygj2nd4 1927 16 ( ( -LRB- cord-009571-mygj2nd4 1927 17 CC CC NNP cord-009571-mygj2nd4 1927 18 ) ) -RRB- cord-009571-mygj2nd4 1927 19 synovial synovial JJ cord-009571-mygj2nd4 1927 20 fluid fluid NN cord-009571-mygj2nd4 1927 21 ( ( -LRB- cord-009571-mygj2nd4 1927 22 Arthritis Arthritis NNP cord-009571-mygj2nd4 1927 23 Rheum Rheum NNP cord-009571-mygj2nd4 1927 24 16:171 16:171 CD cord-009571-mygj2nd4 1927 25 , , , cord-009571-mygj2nd4 1927 26 1973 1973 CD cord-009571-mygj2nd4 1927 27 ) ) -RRB- cord-009571-mygj2nd4 1927 28 suggest suggest VBP cord-009571-mygj2nd4 1927 29 that that IN cord-009571-mygj2nd4 1927 30 PPi PPi NNS cord-009571-mygj2nd4 1927 31 may may MD cord-009571-mygj2nd4 1927 32 be be VB cord-009571-mygj2nd4 1927 33 a a DT cord-009571-mygj2nd4 1927 34 precursory precursory JJ cord-009571-mygj2nd4 1927 35 ion ion NN cord-009571-mygj2nd4 1927 36 involved involve VBN cord-009571-mygj2nd4 1927 37 in in IN cord-009571-mygj2nd4 1927 38 human human JJ cord-009571-mygj2nd4 1927 39 articular articular JJ cord-009571-mygj2nd4 1927 40 mineral mineral NN cord-009571-mygj2nd4 1927 41 formation formation NN cord-009571-mygj2nd4 1927 42 , , , cord-009571-mygj2nd4 1927 43 whether whether IN cord-009571-mygj2nd4 1927 44 in in IN cord-009571-mygj2nd4 1927 45 midzone midzone NN cord-009571-mygj2nd4 1927 46 sites site NNS cord-009571-mygj2nd4 1927 47 in in IN cord-009571-mygj2nd4 1927 48 CC CC NNP cord-009571-mygj2nd4 1927 49 - - HYPH cord-009571-mygj2nd4 1927 50 CaPPi CaPPi NNS cord-009571-mygj2nd4 1927 51 deposition deposition NN cord-009571-mygj2nd4 1927 52 - - : cord-009571-mygj2nd4 1927 53 or or CC cord-009571-mygj2nd4 1927 54 in in IN cord-009571-mygj2nd4 1927 55 " " `` cord-009571-mygj2nd4 1927 56 tidemark tidemark NN cord-009571-mygj2nd4 1927 57 " " '' cord-009571-mygj2nd4 1927 58 cartilage cartilage NN cord-009571-mygj2nd4 1927 59 in in IN cord-009571-mygj2nd4 1927 60 OA OA NNP cord-009571-mygj2nd4 1927 61 . . . cord-009571-mygj2nd4 1928 1 Why why WRB cord-009571-mygj2nd4 1928 2 predominantly predominantly RB cord-009571-mygj2nd4 1928 3 hydroxyapatite hydroxyapatite JJ cord-009571-mygj2nd4 1928 4 and and CC cord-009571-mygj2nd4 1928 5 often often RB cord-009571-mygj2nd4 1928 6 some some DT cord-009571-mygj2nd4 1928 7 CaPPi CaPPi NNS cord-009571-mygj2nd4 1928 8 ( ( -LRB- cord-009571-mygj2nd4 1928 9 Bjelle Bjelle NNP cord-009571-mygj2nd4 1928 10 , , , cord-009571-mygj2nd4 1928 11 personal personal JJ cord-009571-mygj2nd4 1928 12 communication communication NN cord-009571-mygj2nd4 1928 13 ) ) -RRB- cord-009571-mygj2nd4 1928 14 are be VBP cord-009571-mygj2nd4 1928 15 seen see VBN cord-009571-mygj2nd4 1928 16 in in IN cord-009571-mygj2nd4 1928 17 OA OA NNP cord-009571-mygj2nd4 1928 18 , , , cord-009571-mygj2nd4 1928 19 and and CC cord-009571-mygj2nd4 1928 20 CaPPi CaPPi NNS cord-009571-mygj2nd4 1928 21 is be VBZ cord-009571-mygj2nd4 1928 22 deposited deposit VBN cord-009571-mygj2nd4 1928 23 in in IN cord-009571-mygj2nd4 1928 24 CC CC NNP cord-009571-mygj2nd4 1928 25 , , , cord-009571-mygj2nd4 1928 26 might may MD cord-009571-mygj2nd4 1928 27 hypothetically hypothetically RB cord-009571-mygj2nd4 1928 28 depend depend VB cord-009571-mygj2nd4 1928 29 in in IN cord-009571-mygj2nd4 1928 30 part part NN cord-009571-mygj2nd4 1928 31 on on IN cord-009571-mygj2nd4 1928 32 moderate moderate JJ cord-009571-mygj2nd4 1928 33 and and CC cord-009571-mygj2nd4 1928 34 severe severe JJ cord-009571-mygj2nd4 1928 35 PPi PPi NNS cord-009571-mygj2nd4 1928 36 hydrolase(s hydrolase(s RB cord-009571-mygj2nd4 1928 37 ) ) -RRB- cord-009571-mygj2nd4 1928 38 deficiencies deficiency NNS cord-009571-mygj2nd4 1928 39 . . . cord-009571-mygj2nd4 1929 1 Such such JJ cord-009571-mygj2nd4 1929 2 deficiencies deficiency NNS cord-009571-mygj2nd4 1929 3 are be VBP cord-009571-mygj2nd4 1929 4 postulated postulate VBN cord-009571-mygj2nd4 1929 5 to to TO cord-009571-mygj2nd4 1929 6 be be VB cord-009571-mygj2nd4 1929 7 associated associate VBN cord-009571-mygj2nd4 1929 8 with with IN cord-009571-mygj2nd4 1929 9 the the DT cord-009571-mygj2nd4 1929 10 calcifying calcify VBG cord-009571-mygj2nd4 1929 11 subcellular subcellular JJ cord-009571-mygj2nd4 1929 12 apparatus apparatus NN cord-009571-mygj2nd4 1929 13 in in IN cord-009571-mygj2nd4 1929 14 OA OA NNP cord-009571-mygj2nd4 1929 15 and and CC cord-009571-mygj2nd4 1929 16 CC CC NNP cord-009571-mygj2nd4 1929 17 articular articular JJ cord-009571-mygj2nd4 1929 18 cartilage cartilage NN cord-009571-mygj2nd4 1929 19 , , , cord-009571-mygj2nd4 1929 20 respectively respectively RB cord-009571-mygj2nd4 1929 21 . . . cord-009571-mygj2nd4 1930 1 This this DT cord-009571-mygj2nd4 1930 2 postulated postulate VBN cord-009571-mygj2nd4 1930 3 PPi PPi NNS cord-009571-mygj2nd4 1930 4 deficiency deficiency NN cord-009571-mygj2nd4 1930 5 would would MD cord-009571-mygj2nd4 1930 6 be be VB cord-009571-mygj2nd4 1930 7 relative relative JJ cord-009571-mygj2nd4 1930 8 to to IN cord-009571-mygj2nd4 1930 9 normal normal JJ cord-009571-mygj2nd4 1930 10 calcifying calcify VBG cord-009571-mygj2nd4 1930 11 growth growth NN cord-009571-mygj2nd4 1930 12 cartilage cartilage NN cord-009571-mygj2nd4 1930 13 in in IN cord-009571-mygj2nd4 1930 14 which which WDT cord-009571-mygj2nd4 1930 15 PPi PPi NNS cord-009571-mygj2nd4 1930 16 in in IN cord-009571-mygj2nd4 1930 17 mineral mineral NN cord-009571-mygj2nd4 1930 18 is be VBZ cord-009571-mygj2nd4 1930 19 present present JJ cord-009571-mygj2nd4 1930 20 in in IN cord-009571-mygj2nd4 1930 21 only only JJ cord-009571-mygj2nd4 1930 22 trace trace NN cord-009571-mygj2nd4 1930 23 amounts amount NNS cord-009571-mygj2nd4 1930 24 ( ( -LRB- cord-009571-mygj2nd4 1930 25 Wuthier Wuthier NNP cord-009571-mygj2nd4 1930 26 et et NNP cord-009571-mygj2nd4 1930 27 al al NNP cord-009571-mygj2nd4 1930 28 . . NNP cord-009571-mygj2nd4 1930 29 , , , cord-009571-mygj2nd4 1931 1 Calc Calc NNP cord-009571-mygj2nd4 1931 2 Tiss Tiss NNP cord-009571-mygj2nd4 1931 3 Res Res NNP cord-009571-mygj2nd4 1931 4 10198 10198 CD cord-009571-mygj2nd4 1931 5 , , , cord-009571-mygj2nd4 1931 6 1972 1972 CD cord-009571-mygj2nd4 1931 7 ) ) -RRB- cord-009571-mygj2nd4 1931 8 . . . cord-009571-mygj2nd4 1932 1 To to TO cord-009571-mygj2nd4 1932 2 examine examine VB cord-009571-mygj2nd4 1932 3 this this DT cord-009571-mygj2nd4 1932 4 hypothesis hypothesis NN cord-009571-mygj2nd4 1932 5 , , , cord-009571-mygj2nd4 1932 6 articular articular JJ cord-009571-mygj2nd4 1932 7 cartilage cartilage NN cord-009571-mygj2nd4 1932 8 from from IN cord-009571-mygj2nd4 1932 9 8 8 CD cord-009571-mygj2nd4 1932 10 patients patient NNS cord-009571-mygj2nd4 1932 11 with with IN cord-009571-mygj2nd4 1932 12 OA OA NNP cord-009571-mygj2nd4 1932 13 ( ( -LRB- cord-009571-mygj2nd4 1932 14 4 4 CD cord-009571-mygj2nd4 1932 15 male male NN cord-009571-mygj2nd4 1932 16 , , , cord-009571-mygj2nd4 1932 17 4 4 CD cord-009571-mygj2nd4 1932 18 female female NN cord-009571-mygj2nd4 1932 19 , , , cord-009571-mygj2nd4 1932 20 age age NN cord-009571-mygj2nd4 1932 21 49 49 CD cord-009571-mygj2nd4 1932 22 - - SYM cord-009571-mygj2nd4 1932 23 74 74 CD cord-009571-mygj2nd4 1932 24 ) ) -RRB- cord-009571-mygj2nd4 1932 25 , , , cord-009571-mygj2nd4 1932 26 6 6 CD cord-009571-mygj2nd4 1932 27 with with IN cord-009571-mygj2nd4 1932 28 CC CC NNP cord-009571-mygj2nd4 1932 29 ( ( -LRB- cord-009571-mygj2nd4 1932 30 4 4 CD cord-009571-mygj2nd4 1932 31 male male NN cord-009571-mygj2nd4 1932 32 , , , cord-009571-mygj2nd4 1932 33 2 2 CD cord-009571-mygj2nd4 1932 34 female female NN cord-009571-mygj2nd4 1932 35 , , , cord-009571-mygj2nd4 1932 36 age age NN cord-009571-mygj2nd4 1932 37 60 60 CD cord-009571-mygj2nd4 1932 38 - - SYM cord-009571-mygj2nd4 1932 39 79 79 CD cord-009571-mygj2nd4 1932 40 ) ) -RRB- cord-009571-mygj2nd4 1932 41 , , , cord-009571-mygj2nd4 1932 42 and and CC cord-009571-mygj2nd4 1932 43 4 4 CD cord-009571-mygj2nd4 1932 44 normal normal JJ cord-009571-mygj2nd4 1932 45 controls control NNS cord-009571-mygj2nd4 1932 46 was be VBD cord-009571-mygj2nd4 1932 47 assessed assess VBN cord-009571-mygj2nd4 1932 48 for for IN cord-009571-mygj2nd4 1932 49 various various JJ cord-009571-mygj2nd4 1932 50 phosphohydrolase phosphohydrolase NN cord-009571-mygj2nd4 1932 51 activities activity NNS cord-009571-mygj2nd4 1932 52 . . . cord-009571-mygj2nd4 1933 1 Cartilage cartilage NN cord-009571-mygj2nd4 1933 2 was be VBD cord-009571-mygj2nd4 1933 3 sliced slice VBN cord-009571-mygj2nd4 1933 4 in in IN cord-009571-mygj2nd4 1933 5 a a DT cord-009571-mygj2nd4 1933 6 cryostat cryostat NN cord-009571-mygj2nd4 1933 7 , , , cord-009571-mygj2nd4 1933 8 homogenized homogenize VBN cord-009571-mygj2nd4 1933 9 , , , cord-009571-mygj2nd4 1933 10 and and CC cord-009571-mygj2nd4 1933 11 extracted extract VBN cord-009571-mygj2nd4 1933 12 in in IN cord-009571-mygj2nd4 1933 13 Triton Triton NNP cord-009571-mygj2nd4 1933 14 X-100 x-100 NN cord-009571-mygj2nd4 1933 15 . . . cord-009571-mygj2nd4 1934 1 The the DT cord-009571-mygj2nd4 1934 2 extract extract NN cord-009571-mygj2nd4 1934 3 was be VBD cord-009571-mygj2nd4 1934 4 centrifuged centrifuge VBN cord-009571-mygj2nd4 1934 5 and and CC cord-009571-mygj2nd4 1934 6 the the DT cord-009571-mygj2nd4 1934 7 supernatant supernatant NN cord-009571-mygj2nd4 1934 8 , , , cord-009571-mygj2nd4 1934 9 once once RB cord-009571-mygj2nd4 1934 10 dialyzed dialyze VBN cord-009571-mygj2nd4 1934 11 , , , cord-009571-mygj2nd4 1934 12 was be VBD cord-009571-mygj2nd4 1934 13 passed pass VBN cord-009571-mygj2nd4 1934 14 through through IN cord-009571-mygj2nd4 1934 15 a a DT cord-009571-mygj2nd4 1934 16 DE-52 DE-52 NNP cord-009571-mygj2nd4 1934 17 column column NN cord-009571-mygj2nd4 1934 18 and and CC cord-009571-mygj2nd4 1934 19 enzyme enzyme NN cord-009571-mygj2nd4 1934 20 fractions fraction NNS cord-009571-mygj2nd4 1934 21 were be VBD cord-009571-mygj2nd4 1934 22 eluted elute VBN cord-009571-mygj2nd4 1934 23 according accord VBG cord-009571-mygj2nd4 1934 24 to to IN cord-009571-mygj2nd4 1934 25 prevjously prevjously NNP cord-009571-mygj2nd4 1934 26 described describe VBN cord-009571-mygj2nd4 1934 27 techniques technique NNS cord-009571-mygj2nd4 1934 28 . . . cord-009571-mygj2nd4 1935 1 Although although IN cord-009571-mygj2nd4 1935 2 total total JJ cord-009571-mygj2nd4 1935 3 protein protein NN cord-009571-mygj2nd4 1935 4 and and CC cord-009571-mygj2nd4 1935 5 DNA dna NN cord-009571-mygj2nd4 1935 6 content content NN cord-009571-mygj2nd4 1935 7 were be VBD cord-009571-mygj2nd4 1935 8 about about IN cord-009571-mygj2nd4 1935 9 equal equal JJ cord-009571-mygj2nd4 1935 10 from from IN cord-009571-mygj2nd4 1935 11 all all DT cord-009571-mygj2nd4 1935 12 cartilage cartilage NN cord-009571-mygj2nd4 1935 13 samples sample NNS cord-009571-mygj2nd4 1935 14 , , , cord-009571-mygj2nd4 1936 1 alkaline alkaline JJ cord-009571-mygj2nd4 1936 2 phosphatase phosphatase NN cord-009571-mygj2nd4 1936 3 activity activity NN cord-009571-mygj2nd4 1936 4 was be VBD cord-009571-mygj2nd4 1936 5 found find VBN cord-009571-mygj2nd4 1936 6 in in IN cord-009571-mygj2nd4 1936 7 the the DT cord-009571-mygj2nd4 1936 8 following follow VBG cord-009571-mygj2nd4 1936 9 ratios ratio NNS cord-009571-mygj2nd4 1936 10 : : : cord-009571-mygj2nd4 1936 11 normal normal JJ cord-009571-mygj2nd4 1936 12 : : : cord-009571-mygj2nd4 1937 1 CC CC NNP cord-009571-mygj2nd4 1937 2 : : : cord-009571-mygj2nd4 1937 3 OA OA NNP cord-009571-mygj2nd4 1937 4 = = NFP cord-009571-mygj2nd4 1938 1 I -PRON- PRP cord-009571-mygj2nd4 1938 2 : : : cord-009571-mygj2nd4 1938 3 6 6 CD cord-009571-mygj2nd4 1938 4 : : SYM cord-009571-mygj2nd4 1938 5 60 60 CD cord-009571-mygj2nd4 1938 6 . . . cord-009571-mygj2nd4 1939 1 In in IN cord-009571-mygj2nd4 1939 2 all all DT cord-009571-mygj2nd4 1939 3 samples sample NNS cord-009571-mygj2nd4 1939 4 , , , cord-009571-mygj2nd4 1939 5 2 2 CD cord-009571-mygj2nd4 1939 6 peaks peak NNS cord-009571-mygj2nd4 1939 7 of of IN cord-009571-mygj2nd4 1939 8 alkaline alkaline JJ cord-009571-mygj2nd4 1939 9 phosphatase phosphatase NN cord-009571-mygj2nd4 1939 10 activity activity NN cord-009571-mygj2nd4 1939 11 were be VBD cord-009571-mygj2nd4 1939 12 eluted elute VBN cord-009571-mygj2nd4 1939 13 similar similar JJ cord-009571-mygj2nd4 1939 14 to to IN cord-009571-mygj2nd4 1939 15 the the DT cord-009571-mygj2nd4 1939 16 findings finding NNS cord-009571-mygj2nd4 1939 17 of of IN cord-009571-mygj2nd4 1939 18 Arsenis Arsenis NNP cord-009571-mygj2nd4 1939 19 et et NNP cord-009571-mygj2nd4 1939 20 al al NNP cord-009571-mygj2nd4 1939 21 . . . cord-009571-mygj2nd4 1940 1 in in IN cord-009571-mygj2nd4 1940 2 calf calf NN cord-009571-mygj2nd4 1940 3 growth growth NN cord-009571-mygj2nd4 1940 4 cartilage cartilage NN cord-009571-mygj2nd4 1941 1 ( ( -LRB- cord-009571-mygj2nd4 1941 2 Calc Calc NNP cord-009571-mygj2nd4 1941 3 Tiss Tiss NNP cord-009571-mygj2nd4 1941 4 Res Res NNP cord-009571-mygj2nd4 1941 5 20159 20159 CD cord-009571-mygj2nd4 1941 6 , , , cord-009571-mygj2nd4 1941 7 1976 1976 CD cord-009571-mygj2nd4 1941 8 ) ) -RRB- cord-009571-mygj2nd4 1941 9 . . . cord-009571-mygj2nd4 1942 1 Uniquely uniquely RB cord-009571-mygj2nd4 1942 2 , , , cord-009571-mygj2nd4 1942 3 with with IN cord-009571-mygj2nd4 1942 4 CC CC NNP cord-009571-mygj2nd4 1942 5 some some DT cord-009571-mygj2nd4 1942 6 of of IN cord-009571-mygj2nd4 1942 7 the the DT cord-009571-mygj2nd4 1942 8 total total JJ cord-009571-mygj2nd4 1942 9 activity activity NN cord-009571-mygj2nd4 1942 10 ( ( -LRB- cord-009571-mygj2nd4 1942 11 14 14 CD cord-009571-mygj2nd4 1942 12 % % NN cord-009571-mygj2nd4 1942 13 ) ) -RRB- cord-009571-mygj2nd4 1942 14 was be VBD cord-009571-mygj2nd4 1942 15 found find VBN cord-009571-mygj2nd4 1942 16 in in IN cord-009571-mygj2nd4 1942 17 the the DT cord-009571-mygj2nd4 1942 18 void void JJ cord-009571-mygj2nd4 1942 19 volume volume NN cord-009571-mygj2nd4 1942 20 of of IN cord-009571-mygj2nd4 1942 21 both both DT cord-009571-mygj2nd4 1942 22 peaks peak NNS cord-009571-mygj2nd4 1942 23 . . . cord-009571-mygj2nd4 1943 1 Characterization characterization NN cord-009571-mygj2nd4 1943 2 of of IN cord-009571-mygj2nd4 1943 3 alkaline alkaline JJ cord-009571-mygj2nd4 1943 4 phosphatase phosphatase NN cord-009571-mygj2nd4 1943 5 using use VBG cord-009571-mygj2nd4 1943 6 various various JJ cord-009571-mygj2nd4 1943 7 metals metal NNS cord-009571-mygj2nd4 1943 8 , , , cord-009571-mygj2nd4 1943 9 inhibitors inhibitor NNS cord-009571-mygj2nd4 1943 10 , , , cord-009571-mygj2nd4 1943 11 and and CC cord-009571-mygj2nd4 1943 12 substrates substrate NNS cord-009571-mygj2nd4 1943 13 was be VBD cord-009571-mygj2nd4 1943 14 similar similar JJ cord-009571-mygj2nd4 1943 15 for for IN cord-009571-mygj2nd4 1943 16 all all DT cord-009571-mygj2nd4 1943 17 samples sample NNS cord-009571-mygj2nd4 1943 18 tested test VBN cord-009571-mygj2nd4 1943 19 . . . cord-009571-mygj2nd4 1944 1 However however RB cord-009571-mygj2nd4 1944 2 , , , cord-009571-mygj2nd4 1944 3 analysis analysis NN cord-009571-mygj2nd4 1944 4 of of IN cord-009571-mygj2nd4 1944 5 the the DT cord-009571-mygj2nd4 1944 6 ratios ratio NNS cord-009571-mygj2nd4 1944 7 of of IN cord-009571-mygj2nd4 1944 8 PPiase PPiase NNP cord-009571-mygj2nd4 1944 9 : : : cord-009571-mygj2nd4 1944 10 alkaline alkaline JJ cord-009571-mygj2nd4 1944 11 phosphatase phosphatase NN cord-009571-mygj2nd4 1944 12 for for IN cord-009571-mygj2nd4 1944 13 growth growth NN cord-009571-mygj2nd4 1944 14 cartilage cartilage NN cord-009571-mygj2nd4 1945 1 ( ( -LRB- cord-009571-mygj2nd4 1945 2 Arsenis Arsenis NNP cord-009571-mygj2nd4 1945 3 , , , cord-009571-mygj2nd4 1945 4 above above IN cord-009571-mygj2nd4 1945 5 ) ) -RRB- cord-009571-mygj2nd4 1945 6 versus versus IN cord-009571-mygj2nd4 1945 7 OA OA NNP cord-009571-mygj2nd4 1945 8 and and CC cord-009571-mygj2nd4 1945 9 CC cc NN cord-009571-mygj2nd4 1945 10 samples sample NNS cord-009571-mygj2nd4 1945 11 ranged range VBD cord-009571-mygj2nd4 1945 12 from from IN cord-009571-mygj2nd4 1945 13 6 6 CD cord-009571-mygj2nd4 1945 14 : : SYM cord-009571-mygj2nd4 1945 15 1 1 CD cord-009571-mygj2nd4 1945 16 to to IN cord-009571-mygj2nd4 1945 17 3 3 CD cord-009571-mygj2nd4 1945 18 : : SYM cord-009571-mygj2nd4 1945 19 1 1 CD cord-009571-mygj2nd4 1945 20 respectively respectively RB cord-009571-mygj2nd4 1945 21 . . . cord-009571-mygj2nd4 1946 1 In in IN cord-009571-mygj2nd4 1946 2 conclusion conclusion NN cord-009571-mygj2nd4 1946 3 , , , cord-009571-mygj2nd4 1946 4 the the DT cord-009571-mygj2nd4 1946 5 high high JJ cord-009571-mygj2nd4 1946 6 PPiase PPiase NNP cord-009571-mygj2nd4 1946 7 to to IN cord-009571-mygj2nd4 1946 8 alkaline alkaline JJ cord-009571-mygj2nd4 1946 9 phosphatase phosphatase NN cord-009571-mygj2nd4 1946 10 ratio ratio NN cord-009571-mygj2nd4 1946 11 in in IN cord-009571-mygj2nd4 1946 12 growth growth NN cord-009571-mygj2nd4 1946 13 cartilage cartilage NN cord-009571-mygj2nd4 1946 14 compared compare VBN cord-009571-mygj2nd4 1946 15 to to IN cord-009571-mygj2nd4 1946 16 this this DT cord-009571-mygj2nd4 1946 17 ratio ratio NN cord-009571-mygj2nd4 1946 18 in in IN cord-009571-mygj2nd4 1946 19 CC CC NNP cord-009571-mygj2nd4 1946 20 and and CC cord-009571-mygj2nd4 1946 21 OA OA NNP cord-009571-mygj2nd4 1946 22 supports support VBZ cord-009571-mygj2nd4 1946 23 the the DT cord-009571-mygj2nd4 1946 24 view view NN cord-009571-mygj2nd4 1946 25 that that WDT cord-009571-mygj2nd4 1946 26 reduced reduce VBD cord-009571-mygj2nd4 1946 27 PPiase PPiase NNP cord-009571-mygj2nd4 1946 28 activity activity NN cord-009571-mygj2nd4 1946 29 might may MD cord-009571-mygj2nd4 1946 30 play play VB cord-009571-mygj2nd4 1946 31 a a DT cord-009571-mygj2nd4 1946 32 role role NN cord-009571-mygj2nd4 1946 33 in in IN cord-009571-mygj2nd4 1946 34 1 1 CD cord-009571-mygj2nd4 1946 35 ) ) -RRB- cord-009571-mygj2nd4 1947 1 the the DT cord-009571-mygj2nd4 1947 2 probable probable JJ cord-009571-mygj2nd4 1947 3 elaboration elaboration NN cord-009571-mygj2nd4 1947 4 of of IN cord-009571-mygj2nd4 1947 5 PPi PPi NNS cord-009571-mygj2nd4 1947 6 into into IN cord-009571-mygj2nd4 1947 7 synovial synovial JJ cord-009571-mygj2nd4 1947 8 fluid fluid NN cord-009571-mygj2nd4 1947 9 in in IN cord-009571-mygj2nd4 1947 10 OA OA NNP cord-009571-mygj2nd4 1947 11 and and CC cord-009571-mygj2nd4 1947 12 CC CC NNP cord-009571-mygj2nd4 1947 13 ; ; : cord-009571-mygj2nd4 1947 14 2 2 LS cord-009571-mygj2nd4 1947 15 ) ) -RRB- cord-009571-mygj2nd4 1947 16 the the DT cord-009571-mygj2nd4 1947 17 in in FW cord-009571-mygj2nd4 1947 18 vitro vitro FW cord-009571-mygj2nd4 1947 19 elaboration elaboration NN cord-009571-mygj2nd4 1947 20 from from IN cord-009571-mygj2nd4 1947 21 articular articular JJ cord-009571-mygj2nd4 1947 22 cartilage cartilage NN cord-009571-mygj2nd4 1947 23 of of IN cord-009571-mygj2nd4 1947 24 PPi PPi NNS cord-009571-mygj2nd4 1947 25 into into IN cord-009571-mygj2nd4 1947 26 Eagle Eagle NNP cord-009571-mygj2nd4 1947 27 's 's POS cord-009571-mygj2nd4 1947 28 medium medium NN cord-009571-mygj2nd4 1947 29 in in IN cord-009571-mygj2nd4 1947 30 patients patient NNS cord-009571-mygj2nd4 1947 31 with with IN cord-009571-mygj2nd4 1947 32 OA OA NNP cord-009571-mygj2nd4 1947 33 and and CC cord-009571-mygj2nd4 1947 34 CC CC NNP cord-009571-mygj2nd4 1947 35 ( ( -LRB- cord-009571-mygj2nd4 1947 36 J J NNP cord-009571-mygj2nd4 1947 37 Clin Clin NNP cord-009571-mygj2nd4 1947 38 Invest Invest NNP cord-009571-mygj2nd4 1947 39 56:1473 56:1473 CD cord-009571-mygj2nd4 1947 40 , , , cord-009571-mygj2nd4 1947 41 1975 1975 CD cord-009571-mygj2nd4 1947 42 ) ) -RRB- cord-009571-mygj2nd4 1947 43 ; ; : cord-009571-mygj2nd4 1947 44 and and CC cord-009571-mygj2nd4 1947 45 3 3 LS cord-009571-mygj2nd4 1947 46 ) ) -RRB- cord-009571-mygj2nd4 1947 47 provision provision NN cord-009571-mygj2nd4 1947 48 of of IN cord-009571-mygj2nd4 1947 49 PPi PPi NNS cord-009571-mygj2nd4 1947 50 ion ion NN cord-009571-mygj2nd4 1947 51 for for IN cord-009571-mygj2nd4 1947 52 variable variable JJ cord-009571-mygj2nd4 1947 53 CaPPi CaPPi NNS cord-009571-mygj2nd4 1947 54 crystal crystal NN cord-009571-mygj2nd4 1947 55 deposition deposition NN cord-009571-mygj2nd4 1947 56 . . . cord-009571-mygj2nd4 1948 1 Despite despite IN cord-009571-mygj2nd4 1948 2 the the DT cord-009571-mygj2nd4 1948 3 prominence prominence NN cord-009571-mygj2nd4 1948 4 of of IN cord-009571-mygj2nd4 1948 5 neuropsychiatric neuropsychiatric JJ cord-009571-mygj2nd4 1948 6 features feature NNS cord-009571-mygj2nd4 1948 7 in in IN cord-009571-mygj2nd4 1948 8 systemic systemic JJ cord-009571-mygj2nd4 1948 9 lupus lupus NN cord-009571-mygj2nd4 1948 10 erythematosus erythematosus NN cord-009571-mygj2nd4 1948 11 ( ( -LRB- cord-009571-mygj2nd4 1948 12 SLE SLE NNP cord-009571-mygj2nd4 1948 13 ) ) -RRB- cord-009571-mygj2nd4 1948 14 , , , cord-009571-mygj2nd4 1948 15 no no DT cord-009571-mygj2nd4 1948 16 satisfactory satisfactory JJ cord-009571-mygj2nd4 1948 17 method method NN cord-009571-mygj2nd4 1948 18 exists exist VBZ cord-009571-mygj2nd4 1948 19 for for IN cord-009571-mygj2nd4 1948 20 the the DT cord-009571-mygj2nd4 1948 21 diagnosis diagnosis NN cord-009571-mygj2nd4 1948 22 and and CC cord-009571-mygj2nd4 1948 23 monitoring monitoring NN cord-009571-mygj2nd4 1948 24 of of IN cord-009571-mygj2nd4 1948 25 central central JJ cord-009571-mygj2nd4 1948 26 nervous nervous JJ cord-009571-mygj2nd4 1948 27 system system NN cord-009571-mygj2nd4 1948 28 ( ( -LRB- cord-009571-mygj2nd4 1948 29 CNS CNS NNP cord-009571-mygj2nd4 1948 30 ) ) -RRB- cord-009571-mygj2nd4 1948 31 involvement involvement NN cord-009571-mygj2nd4 1948 32 . . . cord-009571-mygj2nd4 1949 1 This this DT cord-009571-mygj2nd4 1949 2 study study NN cord-009571-mygj2nd4 1949 3 describes describe VBZ cord-009571-mygj2nd4 1949 4 the the DT cord-009571-mygj2nd4 1949 5 application application NN cord-009571-mygj2nd4 1949 6 of of IN cord-009571-mygj2nd4 1949 7 a a DT cord-009571-mygj2nd4 1949 8 new new JJ cord-009571-mygj2nd4 1949 9 technique technique NN cord-009571-mygj2nd4 1949 10 for for IN cord-009571-mygj2nd4 1949 11 studying study VBG cord-009571-mygj2nd4 1949 12 both both DT cord-009571-mygj2nd4 1949 13 cerebral cerebral JJ cord-009571-mygj2nd4 1949 14 metabolism metabolism NN cord-009571-mygj2nd4 1949 15 and and CC cord-009571-mygj2nd4 1949 16 blood blood NN cord-009571-mygj2nd4 1949 17 flow flow NN cord-009571-mygj2nd4 1949 18 in in IN cord-009571-mygj2nd4 1949 19 SLE SLE NNP cord-009571-mygj2nd4 1949 20 patients patient NNS cord-009571-mygj2nd4 1949 21 by by IN cord-009571-mygj2nd4 1949 22 using use VBG cord-009571-mygj2nd4 1949 23 inhaled inhale VBN cord-009571-mygj2nd4 1949 24 molecular molecular JJ cord-009571-mygj2nd4 1949 25 15-oxygen 15-oxygen CD cord-009571-mygj2nd4 1949 26 and and CC cord-009571-mygj2nd4 1949 27 15-oxygen 15-oxygen CD cord-009571-mygj2nd4 1949 28 labeled label VBN cord-009571-mygj2nd4 1949 29 carbon carbon NN cord-009571-mygj2nd4 1949 30 dioxide dioxide NN cord-009571-mygj2nd4 1949 31 . . . cord-009571-mygj2nd4 1950 1 Tracer tracer NN cord-009571-mygj2nd4 1950 2 amounts amount NNS cord-009571-mygj2nd4 1950 3 of of IN cord-009571-mygj2nd4 1950 4 15-oxygen 15-oxygen CD cord-009571-mygj2nd4 1950 5 are be VBP cord-009571-mygj2nd4 1950 6 inhaled inhale VBN cord-009571-mygj2nd4 1950 7 , , , cord-009571-mygj2nd4 1950 8 and and CC cord-009571-mygj2nd4 1950 9 after after IN cord-009571-mygj2nd4 1950 10 a a DT cord-009571-mygj2nd4 1950 11 period period NN cord-009571-mygj2nd4 1950 12 of of IN cord-009571-mygj2nd4 1950 13 equilibration equilibration NN cord-009571-mygj2nd4 1950 14 , , , cord-009571-mygj2nd4 1950 15 the the DT cord-009571-mygj2nd4 1950 16 brain brain NN cord-009571-mygj2nd4 1950 17 is be VBZ cord-009571-mygj2nd4 1950 18 scanned scan VBN cord-009571-mygj2nd4 1950 19 with with IN cord-009571-mygj2nd4 1950 20 a a DT cord-009571-mygj2nd4 1950 21 gammacamera gammacamera NN cord-009571-mygj2nd4 1950 22 . . . cord-009571-mygj2nd4 1951 1 The the DT cord-009571-mygj2nd4 1951 2 image image NN cord-009571-mygj2nd4 1951 3 produced produce VBD cord-009571-mygj2nd4 1951 4 represents represent VBZ cord-009571-mygj2nd4 1951 5 cerebral cerebral JJ cord-009571-mygj2nd4 1951 6 metabolism metabolism NN cord-009571-mygj2nd4 1951 7 . . . cord-009571-mygj2nd4 1952 1 The the DT cord-009571-mygj2nd4 1952 2 procedure procedure NN cord-009571-mygj2nd4 1952 3 is be VBZ cord-009571-mygj2nd4 1952 4 repeated repeat VBN cord-009571-mygj2nd4 1952 5 using use VBG cord-009571-mygj2nd4 1952 6 carbon carbon NN cord-009571-mygj2nd4 1952 7 15-dioxide 15-dioxide CD cord-009571-mygj2nd4 1952 8 , , , cord-009571-mygj2nd4 1952 9 and and CC cord-009571-mygj2nd4 1952 10 the the DT cord-009571-mygj2nd4 1952 11 resultant resultant JJ cord-009571-mygj2nd4 1952 12 image image NN cord-009571-mygj2nd4 1952 13 represents represent VBZ cord-009571-mygj2nd4 1952 14 cerebral cerebral JJ cord-009571-mygj2nd4 1952 15 blood blood NN cord-009571-mygj2nd4 1952 16 flow flow NN cord-009571-mygj2nd4 1952 17 . . . cord-009571-mygj2nd4 1953 1 Twenty twenty CD cord-009571-mygj2nd4 1953 2 - - HYPH cord-009571-mygj2nd4 1953 3 eight eight CD cord-009571-mygj2nd4 1953 4 scans scan NNS cord-009571-mygj2nd4 1953 5 were be VBD cord-009571-mygj2nd4 1953 6 performed perform VBN cord-009571-mygj2nd4 1953 7 on on IN cord-009571-mygj2nd4 1953 8 24 24 CD cord-009571-mygj2nd4 1953 9 SLE SLE NNP cord-009571-mygj2nd4 1953 10 patients patient NNS cord-009571-mygj2nd4 1953 11 who who WP cord-009571-mygj2nd4 1953 12 had have VBD cord-009571-mygj2nd4 1953 13 been be VBN cord-009571-mygj2nd4 1953 14 classified classify VBN cord-009571-mygj2nd4 1953 15 as as IN cord-009571-mygj2nd4 1953 16 having have VBG cord-009571-mygj2nd4 1953 17 clinically clinically RB cord-009571-mygj2nd4 1953 18 definite definite JJ cord-009571-mygj2nd4 1953 19 CNS CNS NNP cord-009571-mygj2nd4 1953 20 disease disease NN cord-009571-mygj2nd4 1953 21 ( ( -LRB- cord-009571-mygj2nd4 1953 22 13 13 CD cord-009571-mygj2nd4 1953 23 ) ) -RRB- cord-009571-mygj2nd4 1953 24 , , , cord-009571-mygj2nd4 1953 25 clinically clinically RB cord-009571-mygj2nd4 1953 26 probable probable JJ cord-009571-mygj2nd4 1953 27 CNS CNS NNP cord-009571-mygj2nd4 1953 28 disease disease NN cord-009571-mygj2nd4 1953 29 ( ( -LRB- cord-009571-mygj2nd4 1953 30 7 7 CD cord-009571-mygj2nd4 1953 31 ) ) -RRB- cord-009571-mygj2nd4 1953 32 , , , cord-009571-mygj2nd4 1953 33 or or CC cord-009571-mygj2nd4 1953 34 no no DT cord-009571-mygj2nd4 1953 35 clinical clinical JJ cord-009571-mygj2nd4 1953 36 evidence evidence NN cord-009571-mygj2nd4 1953 37 of of IN cord-009571-mygj2nd4 1953 38 CNS CNS NNP cord-009571-mygj2nd4 1953 39 disease disease NN cord-009571-mygj2nd4 1953 40 ( ( -LRB- cord-009571-mygj2nd4 1953 41 8) 8) NNP cord-009571-mygj2nd4 1953 42 . . . cord-009571-mygj2nd4 1954 1 The the DT cord-009571-mygj2nd4 1954 2 scans scan NNS cord-009571-mygj2nd4 1954 3 , , , cord-009571-mygj2nd4 1954 4 which which WDT cord-009571-mygj2nd4 1954 5 were be VBD cord-009571-mygj2nd4 1954 6 reported report VBN cord-009571-mygj2nd4 1954 7 blind blind JJ cord-009571-mygj2nd4 1954 8 , , , cord-009571-mygj2nd4 1954 9 were be VBD cord-009571-mygj2nd4 1954 10 classified classify VBN cord-009571-mygj2nd4 1954 11 as as IN cord-009571-mygj2nd4 1954 12 normal normal JJ cord-009571-mygj2nd4 1954 13 ( ( -LRB- cord-009571-mygj2nd4 1954 14 showing show VBG cord-009571-mygj2nd4 1954 15 a a DT cord-009571-mygj2nd4 1954 16 full full JJ cord-009571-mygj2nd4 1954 17 pattern pattern NN cord-009571-mygj2nd4 1954 18 of of IN cord-009571-mygj2nd4 1954 19 both both DT cord-009571-mygj2nd4 1954 20 cerebral cerebral JJ cord-009571-mygj2nd4 1954 21 blood blood NN cord-009571-mygj2nd4 1954 22 flow flow NN cord-009571-mygj2nd4 1954 23 and and CC cord-009571-mygj2nd4 1954 24 metabolism metabolism NN cord-009571-mygj2nd4 1954 25 ) ) -RRB- cord-009571-mygj2nd4 1954 26 , , , cord-009571-mygj2nd4 1954 27 as as IN cord-009571-mygj2nd4 1954 28 showing show VBG cord-009571-mygj2nd4 1954 29 a a DT cord-009571-mygj2nd4 1954 30 major major JJ cord-009571-mygj2nd4 1954 31 abnormality abnormality NN cord-009571-mygj2nd4 1954 32 , , , cord-009571-mygj2nd4 1954 33 or or CC cord-009571-mygj2nd4 1954 34 as as IN cord-009571-mygj2nd4 1954 35 showing show VBG cord-009571-mygj2nd4 1954 36 a a DT cord-009571-mygj2nd4 1954 37 minor minor JJ cord-009571-mygj2nd4 1954 38 abnormality abnormality NN cord-009571-mygj2nd4 1954 39 . . . cord-009571-mygj2nd4 1955 1 The the DT cord-009571-mygj2nd4 1955 2 results result NNS cord-009571-mygj2nd4 1955 3 are be VBP cord-009571-mygj2nd4 1955 4 shown show VBN cord-009571-mygj2nd4 1955 5 in in IN cord-009571-mygj2nd4 1955 6 the the DT cord-009571-mygj2nd4 1955 7 table table NN cord-009571-mygj2nd4 1955 8 . . . cord-009571-mygj2nd4 1956 1 Scan scan JJ cord-009571-mygj2nd4 1956 2 abnormalities abnormality NNS cord-009571-mygj2nd4 1956 3 were be VBD cord-009571-mygj2nd4 1956 4 seen see VBN cord-009571-mygj2nd4 1956 5 in in IN cord-009571-mygj2nd4 1956 6 25 25 CD cord-009571-mygj2nd4 1956 7 of of IN cord-009571-mygj2nd4 1956 8 the the DT cord-009571-mygj2nd4 1956 9 28 28 CD cord-009571-mygj2nd4 1956 10 studies study NNS cord-009571-mygj2nd4 1956 11 , , , cord-009571-mygj2nd4 1956 12 usually usually RB cord-009571-mygj2nd4 1956 13 afecting afecte VBG cord-009571-mygj2nd4 1956 14 several several JJ cord-009571-mygj2nd4 1956 15 cortical cortical JJ cord-009571-mygj2nd4 1956 16 areas area NNS cord-009571-mygj2nd4 1956 17 . . . cord-009571-mygj2nd4 1957 1 In in IN cord-009571-mygj2nd4 1957 2 6 6 CD cord-009571-mygj2nd4 1957 3 patients patient NNS cord-009571-mygj2nd4 1957 4 in in IN cord-009571-mygj2nd4 1957 5 whom whom WP cord-009571-mygj2nd4 1957 6 multiple multiple JJ cord-009571-mygj2nd4 1957 7 recordings recording NNS cord-009571-mygj2nd4 1957 8 were be VBD cord-009571-mygj2nd4 1957 9 made make VBN cord-009571-mygj2nd4 1957 10 , , , cord-009571-mygj2nd4 1957 11 improved improve VBN cord-009571-mygj2nd4 1957 12 15-oxygen 15-oxygen CD cord-009571-mygj2nd4 1957 13 scan scan JJ cord-009571-mygj2nd4 1957 14 appearances appearance NNS cord-009571-mygj2nd4 1957 15 correlated correlate VBN cord-009571-mygj2nd4 1957 16 with with IN cord-009571-mygj2nd4 1957 17 clinical clinical JJ cord-009571-mygj2nd4 1957 18 improvement improvement NN cord-009571-mygj2nd4 1957 19 . . . cord-009571-mygj2nd4 1958 1 15-oxygen 15-oxygen CD cord-009571-mygj2nd4 1958 2 brain brain NN cord-009571-mygj2nd4 1958 3 scanning scanning NN cord-009571-mygj2nd4 1958 4 appears appear VBZ cord-009571-mygj2nd4 1958 5 t t NNP cord-009571-mygj2nd4 1958 6 o o UH cord-009571-mygj2nd4 1958 7 offer offer VB cord-009571-mygj2nd4 1958 8 a a DT cord-009571-mygj2nd4 1958 9 highly highly RB cord-009571-mygj2nd4 1958 10 sensitive sensitive JJ cord-009571-mygj2nd4 1958 11 non non JJ cord-009571-mygj2nd4 1958 12 - - JJ cord-009571-mygj2nd4 1958 13 invasive invasive JJ cord-009571-mygj2nd4 1958 14 technique technique NN cord-009571-mygj2nd4 1958 15 for for IN cord-009571-mygj2nd4 1958 16 the the DT cord-009571-mygj2nd4 1958 17 identification identification NN cord-009571-mygj2nd4 1958 18 and and CC cord-009571-mygj2nd4 1958 19 study study NN cord-009571-mygj2nd4 1958 20 of of IN cord-009571-mygj2nd4 1958 21 cerebral cerebral JJ cord-009571-mygj2nd4 1958 22 involvement involvement NN cord-009571-mygj2nd4 1958 23 in in IN cord-009571-mygj2nd4 1958 24 SLE SLE NNP cord-009571-mygj2nd4 1958 25 . . . cord-009571-mygj2nd4 1959 1 Neutrophils neutrophil NNS cord-009571-mygj2nd4 1959 2 stimulated stimulate VBD cord-009571-mygj2nd4 1959 3 at at IN cord-009571-mygj2nd4 1959 4 sites site NNS cord-009571-mygj2nd4 1959 5 of of IN cord-009571-mygj2nd4 1959 6 inflammation inflammation NN cord-009571-mygj2nd4 1959 7 release release NN cord-009571-mygj2nd4 1959 8 lysosomal lysosomal JJ cord-009571-mygj2nd4 1959 9 enzymes enzyme NNS cord-009571-mygj2nd4 1959 10 . . . cord-009571-mygj2nd4 1960 1 Experimentally experimentally RB cord-009571-mygj2nd4 1960 2 , , , cord-009571-mygj2nd4 1960 3 a a DT cord-009571-mygj2nd4 1960 4 variety variety NN cord-009571-mygj2nd4 1960 5 of of IN cord-009571-mygj2nd4 1960 6 agents agent NNS cord-009571-mygj2nd4 1960 7 are be VBP cord-009571-mygj2nd4 1960 8 capable capable JJ cord-009571-mygj2nd4 1960 9 of of IN cord-009571-mygj2nd4 1960 10 stimulating stimulate VBG cord-009571-mygj2nd4 1960 11 neutrophils neutrophil NNS cord-009571-mygj2nd4 1960 12 to to TO cord-009571-mygj2nd4 1960 13 release release VB cord-009571-mygj2nd4 1960 14 their -PRON- PRP$ cord-009571-mygj2nd4 1960 15 lysosomal lysosomal JJ cord-009571-mygj2nd4 1960 16 enzymes enzyme NNS cord-009571-mygj2nd4 1960 17 . . . cord-009571-mygj2nd4 1961 1 Neutrophil Neutrophil NNP cord-009571-mygj2nd4 1961 2 membranes membrane NNS cord-009571-mygj2nd4 1961 3 contain contain VBP cord-009571-mygj2nd4 1961 4 Fc Fc NNP cord-009571-mygj2nd4 1961 5 receptors receptor NNS cord-009571-mygj2nd4 1961 6 for for IN cord-009571-mygj2nd4 1961 7 IgG IgG NNP cord-009571-mygj2nd4 1961 8 , , , cord-009571-mygj2nd4 1961 9 and and CC cord-009571-mygj2nd4 1961 10 thereby thereby RB cord-009571-mygj2nd4 1961 11 possess possess VB cord-009571-mygj2nd4 1961 12 surface surface NN cord-009571-mygj2nd4 1961 13 bound bind VBN cord-009571-mygj2nd4 1962 1 IgG. IgG. NNP cord-009571-mygj2nd4 1963 1 In in IN cord-009571-mygj2nd4 1963 2 these these DT cord-009571-mygj2nd4 1963 3 studies study NNS cord-009571-mygj2nd4 1963 4 we -PRON- PRP cord-009571-mygj2nd4 1963 5 examined examine VBD cord-009571-mygj2nd4 1963 6 the the DT cord-009571-mygj2nd4 1963 7 hypothesis hypothesis NN cord-009571-mygj2nd4 1963 8 that that IN cord-009571-mygj2nd4 1963 9 specific specific JJ cord-009571-mygj2nd4 1963 10 antibodies antibody NNS cord-009571-mygj2nd4 1963 11 could could MD cord-009571-mygj2nd4 1963 12 combine combine VB cord-009571-mygj2nd4 1963 13 with with IN cord-009571-mygj2nd4 1963 14 surface surface NN cord-009571-mygj2nd4 1963 15 bound bind VBN cord-009571-mygj2nd4 1963 16 IgG igg NN cord-009571-mygj2nd4 1963 17 , , , cord-009571-mygj2nd4 1963 18 perturb perturb VB cord-009571-mygj2nd4 1963 19 the the DT cord-009571-mygj2nd4 1963 20 cell cell NN cord-009571-mygj2nd4 1963 21 membrane membrane NN cord-009571-mygj2nd4 1963 22 , , , cord-009571-mygj2nd4 1963 23 and and CC cord-009571-mygj2nd4 1963 24 provoke provoke VB cord-009571-mygj2nd4 1963 25 inflammatory inflammatory JJ cord-009571-mygj2nd4 1963 26 responses response NNS cord-009571-mygj2nd4 1963 27 of of IN cord-009571-mygj2nd4 1963 28 neutrophils neutrophil NNS cord-009571-mygj2nd4 1963 29 . . . cord-009571-mygj2nd4 1964 1 Antisera Antisera NNP cord-009571-mygj2nd4 1964 2 were be VBD cord-009571-mygj2nd4 1964 3 raised raise VBN cord-009571-mygj2nd4 1964 4 to to IN cord-009571-mygj2nd4 1964 5 immunoglobulins immunoglobulin NNS cord-009571-mygj2nd4 1964 6 G g NN cord-009571-mygj2nd4 1964 7 , , , cord-009571-mygj2nd4 1964 8 M M NNP cord-009571-mygj2nd4 1964 9 , , , cord-009571-mygj2nd4 1964 10 A A NNP cord-009571-mygj2nd4 1964 11 , , , cord-009571-mygj2nd4 1964 12 D D NNP cord-009571-mygj2nd4 1964 13 , , , cord-009571-mygj2nd4 1964 14 E E NNP cord-009571-mygj2nd4 1964 15 , , , cord-009571-mygj2nd4 1964 16 and and CC cord-009571-mygj2nd4 1964 17 isolated isolate VBD cord-009571-mygj2nd4 1964 18 y y NNP cord-009571-mygj2nd4 1964 19 chains chain NNS cord-009571-mygj2nd4 1964 20 , , , cord-009571-mygj2nd4 1964 21 Fc Fc NNP cord-009571-mygj2nd4 1964 22 and and CC cord-009571-mygj2nd4 1964 23 F(ab F(ab NNP cord-009571-mygj2nd4 1964 24 ' ' '' cord-009571-mygj2nd4 1964 25 ) ) -RRB- cord-009571-mygj2nd4 1964 26 , , , cord-009571-mygj2nd4 1964 27 of of IN cord-009571-mygj2nd4 1964 28 IgG. IgG. NNP cord-009571-mygj2nd4 1965 1 These these DT cord-009571-mygj2nd4 1965 2 were be VBD cord-009571-mygj2nd4 1965 3 rendered render VBN cord-009571-mygj2nd4 1965 4 monospecific monospecific JJ cord-009571-mygj2nd4 1965 5 by by IN cord-009571-mygj2nd4 1965 6 solid solid JJ cord-009571-mygj2nd4 1965 7 phase phase NN cord-009571-mygj2nd4 1965 8 immunoabsorbents immunoabsorbent NNS cord-009571-mygj2nd4 1965 9 . . . cord-009571-mygj2nd4 1966 1 Isolated isolated JJ cord-009571-mygj2nd4 1966 2 normal normal JJ cord-009571-mygj2nd4 1966 3 human human JJ cord-009571-mygj2nd4 1966 4 peripheral peripheral JJ cord-009571-mygj2nd4 1966 5 blood blood NN cord-009571-mygj2nd4 1966 6 neutrophils neutrophil NNS cord-009571-mygj2nd4 1966 7 were be VBD cord-009571-mygj2nd4 1966 8 incubated incubate VBN cord-009571-mygj2nd4 1966 9 with with IN cord-009571-mygj2nd4 1966 10 specific specific JJ cord-009571-mygj2nd4 1966 11 antisera antisera NN cord-009571-mygj2nd4 1966 12 and and CC cord-009571-mygj2nd4 1966 13 the the DT cord-009571-mygj2nd4 1966 14 release release NN cord-009571-mygj2nd4 1966 15 of of IN cord-009571-mygj2nd4 1966 16 lysosomal lysosomal NN cord-009571-mygj2nd4 1967 1 /3-glucuronidase /3-glucuronidase NNP cord-009571-mygj2nd4 1967 2 , , , cord-009571-mygj2nd4 1967 3 a a DT cord-009571-mygj2nd4 1967 4 - - HYPH cord-009571-mygj2nd4 1967 5 mannosidase mannosidase NN cord-009571-mygj2nd4 1967 6 , , , cord-009571-mygj2nd4 1967 7 and and CC cord-009571-mygj2nd4 1967 8 lysozyme lysozyme NNS cord-009571-mygj2nd4 1967 9 were be VBD cord-009571-mygj2nd4 1967 10 measured measure VBN cord-009571-mygj2nd4 1967 11 . . . cord-009571-mygj2nd4 1968 1 Non non JJ cord-009571-mygj2nd4 1968 2 - - JJ cord-009571-mygj2nd4 1968 3 lethal lethal JJ cord-009571-mygj2nd4 1968 4 release release NN cord-009571-mygj2nd4 1968 5 of of IN cord-009571-mygj2nd4 1968 6 lysosomal lysosomal JJ cord-009571-mygj2nd4 1968 7 enzymes enzyme NNS cord-009571-mygj2nd4 1968 8 was be VBD cord-009571-mygj2nd4 1968 9 observed observe VBN cord-009571-mygj2nd4 1968 10 with with IN cord-009571-mygj2nd4 1968 11 antisera antisera NN cord-009571-mygj2nd4 1968 12 to to IN cord-009571-mygj2nd4 1968 13 whole whole JJ cord-009571-mygj2nd4 1968 14 IgG IgG NNP cord-009571-mygj2nd4 1968 15 , , , cord-009571-mygj2nd4 1968 16 IgA IgA NNP cord-009571-mygj2nd4 1968 17 and and CC cord-009571-mygj2nd4 1968 18 t t NNP cord-009571-mygj2nd4 1968 19 o o NNP cord-009571-mygj2nd4 1968 20 y y NNP cord-009571-mygj2nd4 1968 21 and and CC cord-009571-mygj2nd4 1968 22 Fc Fc NNP cord-009571-mygj2nd4 1968 23 of of IN cord-009571-mygj2nd4 1968 24 IgG. IgG. NNP cord-009571-mygj2nd4 1968 25 The the DT cord-009571-mygj2nd4 1968 26 IgG igg NN cord-009571-mygj2nd4 1968 27 fraction fraction NN cord-009571-mygj2nd4 1968 28 of of IN cord-009571-mygj2nd4 1968 29 anti anti JJ cord-009571-mygj2nd4 1968 30 - - JJ cord-009571-mygj2nd4 1968 31 IgG igg JJ cord-009571-mygj2nd4 1968 32 antiserum antiserum NN cord-009571-mygj2nd4 1968 33 also also RB cord-009571-mygj2nd4 1968 34 stimulated stimulate VBD cord-009571-mygj2nd4 1968 35 non non JJ cord-009571-mygj2nd4 1968 36 - - JJ cord-009571-mygj2nd4 1968 37 lethal lethal JJ cord-009571-mygj2nd4 1968 38 release release NN cord-009571-mygj2nd4 1968 39 , , , cord-009571-mygj2nd4 1968 40 thereby thereby RB cord-009571-mygj2nd4 1968 41 suggesting suggest VBG cord-009571-mygj2nd4 1968 42 that that IN cord-009571-mygj2nd4 1968 43 the the DT cord-009571-mygj2nd4 1968 44 response response NN cord-009571-mygj2nd4 1968 45 was be VBD cord-009571-mygj2nd4 1968 46 not not RB cord-009571-mygj2nd4 1968 47 complement complement NN cord-009571-mygj2nd4 1968 48 - - HYPH cord-009571-mygj2nd4 1968 49 mediated mediate VBN cord-009571-mygj2nd4 1968 50 . . . cord-009571-mygj2nd4 1969 1 Specific specific JJ cord-009571-mygj2nd4 1969 2 IgG igg NN cord-009571-mygj2nd4 1969 3 and and CC cord-009571-mygj2nd4 1969 4 IgA IgA NNP cord-009571-mygj2nd4 1969 5 receptors receptor NNS cord-009571-mygj2nd4 1969 6 were be VBD cord-009571-mygj2nd4 1969 7 detected detect VBN cord-009571-mygj2nd4 1969 8 on on IN cord-009571-mygj2nd4 1969 9 neutrophils neutrophil NNS cord-009571-mygj2nd4 1969 10 using use VBG cord-009571-mygj2nd4 1969 11 immunofluorescent immunofluorescent NN cord-009571-mygj2nd4 1969 12 labeled label VBN cord-009571-mygj2nd4 1969 13 antibodies antibody NNS cord-009571-mygj2nd4 1969 14 . . . cord-009571-mygj2nd4 1970 1 N n NN cord-009571-mygj2nd4 1970 2 o o NN cord-009571-mygj2nd4 1971 1 such such JJ cord-009571-mygj2nd4 1971 2 receptors receptor NNS cord-009571-mygj2nd4 1971 3 were be VBD cord-009571-mygj2nd4 1971 4 detected detect VBN cord-009571-mygj2nd4 1971 5 for for IN cord-009571-mygj2nd4 1971 6 IgM IgM NNP cord-009571-mygj2nd4 1972 1 and and CC cord-009571-mygj2nd4 1972 2 IgD. IgD. NNP cord-009571-mygj2nd4 1972 3 These these DT cord-009571-mygj2nd4 1972 4 results result NNS cord-009571-mygj2nd4 1972 5 indicate indicate VBP cord-009571-mygj2nd4 1972 6 that that IN cord-009571-mygj2nd4 1972 7 inflammatory inflammatory JJ cord-009571-mygj2nd4 1972 8 responses response NNS cord-009571-mygj2nd4 1972 9 of of IN cord-009571-mygj2nd4 1972 10 neutrophils neutrophil NNS cord-009571-mygj2nd4 1972 11 can can MD cord-009571-mygj2nd4 1972 12 be be VB cord-009571-mygj2nd4 1972 13 triggered trigger VBN cord-009571-mygj2nd4 1972 14 directly directly RB cord-009571-mygj2nd4 1972 15 by by IN cord-009571-mygj2nd4 1972 16 anti anti JJ cord-009571-mygj2nd4 1972 17 - - NNS cord-009571-mygj2nd4 1972 18 immunoglobulins immunoglobulins JJ cord-009571-mygj2nd4 1972 19 , , , cord-009571-mygj2nd4 1972 20 and and CC cord-009571-mygj2nd4 1972 21 suggest suggest VB cord-009571-mygj2nd4 1972 22 one one CD cord-009571-mygj2nd4 1972 23 mechanism mechanism NN cord-009571-mygj2nd4 1972 24 for for IN cord-009571-mygj2nd4 1972 25 initiation initiation NN cord-009571-mygj2nd4 1972 26 of of IN cord-009571-mygj2nd4 1972 27 the the DT cord-009571-mygj2nd4 1972 28 inflammatory inflammatory JJ cord-009571-mygj2nd4 1972 29 response response NN cord-009571-mygj2nd4 1972 30 in in IN cord-009571-mygj2nd4 1972 31 patients patient NNS cord-009571-mygj2nd4 1972 32 with with IN cord-009571-mygj2nd4 1972 33 diseases disease NNS cord-009571-mygj2nd4 1972 34 characterized characterize VBN cord-009571-mygj2nd4 1972 35 by by IN cord-009571-mygj2nd4 1972 36 the the DT cord-009571-mygj2nd4 1972 37 presence presence NN cord-009571-mygj2nd4 1972 38 of of IN cord-009571-mygj2nd4 1972 39 antibodies antibody NNS cord-009571-mygj2nd4 1972 40 to to IN cord-009571-mygj2nd4 1972 41 IgG IgG NNP cord-009571-mygj2nd4 1972 42 and and CC cord-009571-mygj2nd4 1972 43 other other JJ cord-009571-mygj2nd4 1972 44 immunoglobulins immunoglobulin NNS cord-009571-mygj2nd4 1972 45 . . . cord-009571-mygj2nd4 1973 1 Incubation incubation NN cord-009571-mygj2nd4 1973 2 of of IN cord-009571-mygj2nd4 1973 3 polymorphonuclear polymorphonuclear JJ cord-009571-mygj2nd4 1973 4 leukocytes leukocyte NNS cord-009571-mygj2nd4 1973 5 ( ( -LRB- cord-009571-mygj2nd4 1973 6 PMN PMN NNP cord-009571-mygj2nd4 1973 7 ) ) -RRB- cord-009571-mygj2nd4 1973 8 with with IN cord-009571-mygj2nd4 1973 9 immune immune JJ cord-009571-mygj2nd4 1973 10 complexes complex NNS cord-009571-mygj2nd4 1973 11 trapped trap VBN cord-009571-mygj2nd4 1973 12 in in IN cord-009571-mygj2nd4 1973 13 micropore micropore NN cord-009571-mygj2nd4 1973 14 or or CC cord-009571-mygj2nd4 1973 15 collagen collagen NN cord-009571-mygj2nd4 1973 16 membranes membrane NNS cord-009571-mygj2nd4 1973 17 results result NNS cord-009571-mygj2nd4 1973 18 in in IN cord-009571-mygj2nd4 1973 19 the the DT cord-009571-mygj2nd4 1973 20 phenomenon phenomenon NN cord-009571-mygj2nd4 1973 21 of of IN cord-009571-mygj2nd4 1973 22 " " `` cord-009571-mygj2nd4 1973 23 frustrated frustrated JJ cord-009571-mygj2nd4 1973 24 phagocytosis phagocytosis NN cord-009571-mygj2nd4 1973 25 , , , cord-009571-mygj2nd4 1973 26 " " '' cord-009571-mygj2nd4 1973 27 that that RB cord-009571-mygj2nd4 1973 28 is is RB cord-009571-mygj2nd4 1973 29 , , , cord-009571-mygj2nd4 1973 30 enhanced enhanced JJ cord-009571-mygj2nd4 1973 31 release release NN cord-009571-mygj2nd4 1973 32 of of IN cord-009571-mygj2nd4 1973 33 lysosomal lysosomal JJ cord-009571-mygj2nd4 1973 34 hydrolases hydrolase NNS cord-009571-mygj2nd4 1973 35 . . . cord-009571-mygj2nd4 1974 1 W w NN cord-009571-mygj2nd4 1974 2 e e NN cord-009571-mygj2nd4 1974 3 have have VBP cord-009571-mygj2nd4 1974 4 previously previously RB cord-009571-mygj2nd4 1974 5 shown show VBN cord-009571-mygj2nd4 1974 6 immune immune JJ cord-009571-mygj2nd4 1974 7 complexes complex NNS cord-009571-mygj2nd4 1974 8 irreversibly irreversibly RB cord-009571-mygj2nd4 1974 9 trapped trap VBN cord-009571-mygj2nd4 1974 10 in in IN cord-009571-mygj2nd4 1974 11 joint joint JJ cord-009571-mygj2nd4 1974 12 collagenous collagenous JJ cord-009571-mygj2nd4 1974 13 tissues tissue NNS cord-009571-mygj2nd4 1974 14 in in IN cord-009571-mygj2nd4 1974 15 antigen antigen NN cord-009571-mygj2nd4 1974 16 - - HYPH cord-009571-mygj2nd4 1974 17 induced induce VBN cord-009571-mygj2nd4 1974 18 rabbit rabbit NN cord-009571-mygj2nd4 1974 19 experimental experimental JJ cord-009571-mygj2nd4 1974 20 arthritis arthritis NN cord-009571-mygj2nd4 1974 21 and and CC cord-009571-mygj2nd4 1974 22 in in IN cord-009571-mygj2nd4 1974 23 rheumatoid rheumatoid JJ cord-009571-mygj2nd4 1974 24 arthritis arthritis NN cord-009571-mygj2nd4 1974 25 . . . cord-009571-mygj2nd4 1975 1 The the DT cord-009571-mygj2nd4 1975 2 present present JJ cord-009571-mygj2nd4 1975 3 experiments experiment NNS cord-009571-mygj2nd4 1975 4 were be VBD cord-009571-mygj2nd4 1975 5 designed design VBN cord-009571-mygj2nd4 1975 6 t t NNP cord-009571-mygj2nd4 1975 7 o o UH cord-009571-mygj2nd4 1975 8 investigate investigate VB cord-009571-mygj2nd4 1975 9 in in IN cord-009571-mygj2nd4 1975 10 vitro vitro FW cord-009571-mygj2nd4 1975 11 interactions interaction NNS cord-009571-mygj2nd4 1975 12 between between IN cord-009571-mygj2nd4 1975 13 PMN PMN NNP cord-009571-mygj2nd4 1975 14 and and CC cord-009571-mygj2nd4 1975 15 joint joint JJ cord-009571-mygj2nd4 1975 16 collagenous collagenous JJ cord-009571-mygj2nd4 1975 17 tissues tissue NNS cord-009571-mygj2nd4 1975 18 obtained obtain VBN cord-009571-mygj2nd4 1975 19 from from IN cord-009571-mygj2nd4 1975 20 rabbit rabbit NN cord-009571-mygj2nd4 1975 21 joints joint NNS cord-009571-mygj2nd4 1975 22 with with IN cord-009571-mygj2nd4 1975 23 experimental experimental JJ cord-009571-mygj2nd4 1975 24 arthritis arthritis NN cord-009571-mygj2nd4 1975 25 or or CC cord-009571-mygj2nd4 1975 26 control control NN cord-009571-mygj2nd4 1975 27 tissues tissue NNS cord-009571-mygj2nd4 1975 28 from from IN cord-009571-mygj2nd4 1975 29 saline saline NN cord-009571-mygj2nd4 1975 30 or or CC cord-009571-mygj2nd4 1975 31 monosodium monosodium NN cord-009571-mygj2nd4 1975 32 urate urate NN cord-009571-mygj2nd4 1975 33 crystal crystal NN cord-009571-mygj2nd4 1975 34 - - HYPH cord-009571-mygj2nd4 1975 35 injected inject VBN cord-009571-mygj2nd4 1975 36 joints joint NNS cord-009571-mygj2nd4 1975 37 . . . cord-009571-mygj2nd4 1976 1 Experimental experimental JJ cord-009571-mygj2nd4 1976 2 and and CC cord-009571-mygj2nd4 1976 3 control control VB cord-009571-mygj2nd4 1976 4 articular articular JJ cord-009571-mygj2nd4 1976 5 cartilage cartilage NN cord-009571-mygj2nd4 1976 6 samples sample NNS cord-009571-mygj2nd4 1976 7 and and CC cord-009571-mygj2nd4 1976 8 menisci meniscus NNS cord-009571-mygj2nd4 1976 9 obtained obtain VBN cord-009571-mygj2nd4 1976 10 from from IN cord-009571-mygj2nd4 1976 11 such such JJ cord-009571-mygj2nd4 1976 12 animals animal NNS cord-009571-mygj2nd4 1976 13 were be VBD cord-009571-mygj2nd4 1976 14 incubated incubate VBN cord-009571-mygj2nd4 1976 15 for for IN cord-009571-mygj2nd4 1976 16 1 1 CD cord-009571-mygj2nd4 1976 17 hour hour NN cord-009571-mygj2nd4 1976 18 with with IN cord-009571-mygj2nd4 1976 19 normal normal JJ cord-009571-mygj2nd4 1976 20 PMN PMN NNP cord-009571-mygj2nd4 1976 21 isolated isolate VBN cord-009571-mygj2nd4 1976 22 from from IN cord-009571-mygj2nd4 1976 23 rabbit rabbit NN cord-009571-mygj2nd4 1976 24 peritoneal peritoneal JJ cord-009571-mygj2nd4 1976 25 exudates exudate NNS cord-009571-mygj2nd4 1976 26 or or CC cord-009571-mygj2nd4 1976 27 blood blood NN cord-009571-mygj2nd4 1976 28 . . . cord-009571-mygj2nd4 1977 1 After after IN cord-009571-mygj2nd4 1977 2 fixation fixation NN cord-009571-mygj2nd4 1977 3 , , , cord-009571-mygj2nd4 1977 4 the the DT cord-009571-mygj2nd4 1977 5 tissues tissue NNS cord-009571-mygj2nd4 1977 6 were be VBD cord-009571-mygj2nd4 1977 7 examined examine VBN cord-009571-mygj2nd4 1977 8 by by IN cord-009571-mygj2nd4 1977 9 electron electron NN cord-009571-mygj2nd4 1977 10 microscopy microscopy NN cord-009571-mygj2nd4 1977 11 . . . cord-009571-mygj2nd4 1978 1 Fresh fresh JJ cord-009571-mygj2nd4 1978 2 cartilage cartilage NN cord-009571-mygj2nd4 1978 3 and and CC cord-009571-mygj2nd4 1978 4 menisci meniscus NNS cord-009571-mygj2nd4 1978 5 from from IN cord-009571-mygj2nd4 1978 6 arthritic arthritic JJ cord-009571-mygj2nd4 1978 7 joints joint NNS cord-009571-mygj2nd4 1978 8 showed show VBD cord-009571-mygj2nd4 1978 9 only only RB cord-009571-mygj2nd4 1978 10 few few JJ cord-009571-mygj2nd4 1978 11 damaged damage VBN cord-009571-mygj2nd4 1978 12 PMN PMN NNP cord-009571-mygj2nd4 1978 13 near near IN cord-009571-mygj2nd4 1978 14 the the DT cord-009571-mygj2nd4 1978 15 articular articular JJ cord-009571-mygj2nd4 1978 16 surface surface NN cord-009571-mygj2nd4 1978 17 . . . cord-009571-mygj2nd4 1979 1 After after IN cord-009571-mygj2nd4 1979 2 incubation incubation NN cord-009571-mygj2nd4 1979 3 with with IN cord-009571-mygj2nd4 1979 4 PMN PMN NNP cord-009571-mygj2nd4 1979 5 , , , cord-009571-mygj2nd4 1979 6 large large JJ cord-009571-mygj2nd4 1979 7 numbers number NNS cord-009571-mygj2nd4 1979 8 of of IN cord-009571-mygj2nd4 1979 9 PMN PMN NNP cord-009571-mygj2nd4 1979 10 attached attach VBN cord-009571-mygj2nd4 1979 11 to to IN cord-009571-mygj2nd4 1979 12 the the DT cord-009571-mygj2nd4 1979 13 articular articular JJ cord-009571-mygj2nd4 1979 14 surface surface NN cord-009571-mygj2nd4 1979 15 were be VBD cord-009571-mygj2nd4 1979 16 seen see VBN cord-009571-mygj2nd4 1979 17 . . . cord-009571-mygj2nd4 1980 1 In in IN cord-009571-mygj2nd4 1980 2 areas area NNS cord-009571-mygj2nd4 1980 3 of of IN cord-009571-mygj2nd4 1980 4 superficial superficial JJ cord-009571-mygj2nd4 1980 5 erosion erosion NN cord-009571-mygj2nd4 1980 6 , , , cord-009571-mygj2nd4 1980 7 the the DT cord-009571-mygj2nd4 1980 8 PMN PMN NNP cord-009571-mygj2nd4 1980 9 invaded invade VBD cord-009571-mygj2nd4 1980 10 the the DT cord-009571-mygj2nd4 1980 11 tissue tissue NN cord-009571-mygj2nd4 1980 12 several several JJ cord-009571-mygj2nd4 1980 13 cell cell NN cord-009571-mygj2nd4 1980 14 diameters diameter NNS cord-009571-mygj2nd4 1980 15 below below IN cord-009571-mygj2nd4 1980 16 the the DT cord-009571-mygj2nd4 1980 17 lamina lamina JJ cord-009571-mygj2nd4 1980 18 splendens splendens NN cord-009571-mygj2nd4 1980 19 . . . cord-009571-mygj2nd4 1981 1 Degranulated Degranulated NNP cord-009571-mygj2nd4 1981 2 PMN PMN NNP cord-009571-mygj2nd4 1981 3 were be VBD cord-009571-mygj2nd4 1981 4 observed observe VBN cord-009571-mygj2nd4 1981 5 with with IN cord-009571-mygj2nd4 1981 6 immunoelectron immunoelectron NNP cord-009571-mygj2nd4 1981 7 microscopy microscopy NNP cord-009571-mygj2nd4 1981 8 in in IN cord-009571-mygj2nd4 1981 9 scattered scatter VBN cord-009571-mygj2nd4 1981 10 areas area NNS cord-009571-mygj2nd4 1981 11 to to IN cord-009571-mygj2nd4 1981 12 phagocytose phagocytose JJ cord-009571-mygj2nd4 1981 13 amorphous amorphous JJ cord-009571-mygj2nd4 1981 14 material material NN cord-009571-mygj2nd4 1981 15 containing contain VBG cord-009571-mygj2nd4 1981 16 rabbit rabbit NN cord-009571-mygj2nd4 1981 17 Ig Ig NNP cord-009571-mygj2nd4 1981 18 . . . cord-009571-mygj2nd4 1982 1 Following follow VBG cord-009571-mygj2nd4 1982 2 addition addition NN cord-009571-mygj2nd4 1982 3 of of IN cord-009571-mygj2nd4 1982 4 PMN PMN NNP cord-009571-mygj2nd4 1982 5 t t NN cord-009571-mygj2nd4 1982 6 o o NN cord-009571-mygj2nd4 1982 7 control control NN cord-009571-mygj2nd4 1982 8 tissues tissue NNS cord-009571-mygj2nd4 1982 9 , , , cord-009571-mygj2nd4 1982 10 only only RB cord-009571-mygj2nd4 1982 11 a a DT cord-009571-mygj2nd4 1982 12 few few JJ cord-009571-mygj2nd4 1982 13 PMN PMN NNP cord-009571-mygj2nd4 1982 14 became become VBD cord-009571-mygj2nd4 1982 15 attached attach VBN cord-009571-mygj2nd4 1982 16 to to IN cord-009571-mygj2nd4 1982 17 the the DT cord-009571-mygj2nd4 1982 18 articular articular JJ cord-009571-mygj2nd4 1982 19 surface surface NN cord-009571-mygj2nd4 1982 20 . . . cord-009571-mygj2nd4 1983 1 In in IN cord-009571-mygj2nd4 1983 2 monosodium monosodium NN cord-009571-mygj2nd4 1983 3 urate urate NN cord-009571-mygj2nd4 1983 4 injected inject VBD cord-009571-mygj2nd4 1983 5 joints joint NNS cord-009571-mygj2nd4 1983 6 , , , cord-009571-mygj2nd4 1983 7 after after IN cord-009571-mygj2nd4 1983 8 incubation incubation NN cord-009571-mygj2nd4 1983 9 with with IN cord-009571-mygj2nd4 1983 10 PMN PMN NNP cord-009571-mygj2nd4 1983 11 , , , cord-009571-mygj2nd4 1983 12 these these DT cord-009571-mygj2nd4 1983 13 cells cell NNS cord-009571-mygj2nd4 1983 14 were be VBD cord-009571-mygj2nd4 1983 15 found find VBN cord-009571-mygj2nd4 1983 16 attached attach VBN cord-009571-mygj2nd4 1983 17 to to IN cord-009571-mygj2nd4 1983 18 the the DT cord-009571-mygj2nd4 1983 19 surface surface NN cord-009571-mygj2nd4 1983 20 in in IN cord-009571-mygj2nd4 1983 21 moderate moderate JJ cord-009571-mygj2nd4 1983 22 numbers number NNS cord-009571-mygj2nd4 1983 23 , , , cord-009571-mygj2nd4 1983 24 but but CC cord-009571-mygj2nd4 1983 25 no no DT cord-009571-mygj2nd4 1983 26 invasion invasion NN cord-009571-mygj2nd4 1983 27 into into IN cord-009571-mygj2nd4 1983 28 the the DT cord-009571-mygj2nd4 1983 29 tissues tissue NNS cord-009571-mygj2nd4 1983 30 was be VBD cord-009571-mygj2nd4 1983 31 seen see VBN cord-009571-mygj2nd4 1983 32 . . . cord-009571-mygj2nd4 1984 1 These these DT cord-009571-mygj2nd4 1984 2 studies study NNS cord-009571-mygj2nd4 1984 3 indicate indicate VBP cord-009571-mygj2nd4 1984 4 that that IN cord-009571-mygj2nd4 1984 5 immune immune JJ cord-009571-mygj2nd4 1984 6 complexes complex NNS cord-009571-mygj2nd4 1984 7 trapped trap VBN cord-009571-mygj2nd4 1984 8 in in IN cord-009571-mygj2nd4 1984 9 joint joint JJ cord-009571-mygj2nd4 1984 10 collagenous collagenous JJ cord-009571-mygj2nd4 1984 11 tissues tissue NNS cord-009571-mygj2nd4 1984 12 may may MD cord-009571-mygj2nd4 1984 13 induce induce VB cord-009571-mygj2nd4 1984 14 the the DT cord-009571-mygj2nd4 1984 15 phenomenon phenomenon NN cord-009571-mygj2nd4 1984 16 of of IN cord-009571-mygj2nd4 1984 17 " " `` cord-009571-mygj2nd4 1984 18 frustrated frustrated JJ cord-009571-mygj2nd4 1984 19 phagocytosis phagocytosis NN cord-009571-mygj2nd4 1984 20 " " '' cord-009571-mygj2nd4 1984 21 leading lead VBG cord-009571-mygj2nd4 1984 22 to to IN cord-009571-mygj2nd4 1984 23 enhanced enhanced JJ cord-009571-mygj2nd4 1984 24 release release NN cord-009571-mygj2nd4 1984 25 of of IN cord-009571-mygj2nd4 1984 26 lysosomal lysosomal JJ cord-009571-mygj2nd4 1984 27 hydrolases hydrolase NNS cord-009571-mygj2nd4 1984 28 . . . cord-009571-mygj2nd4 1985 1 Similar similar JJ cord-009571-mygj2nd4 1985 2 studies study NNS cord-009571-mygj2nd4 1985 3 using use VBG cord-009571-mygj2nd4 1985 4 rheumatoid rheumatoid NN cord-009571-mygj2nd4 1985 5 joint joint JJ cord-009571-mygj2nd4 1985 6 tissues tissue NNS cord-009571-mygj2nd4 1985 7 are be VBP cord-009571-mygj2nd4 1985 8 in in IN cord-009571-mygj2nd4 1985 9 progress progress NN cord-009571-mygj2nd4 1985 10 . . . cord-009571-mygj2nd4 1986 1 ( ( -LRB- cord-009571-mygj2nd4 1986 2 Suppported suppporte VBN cord-009571-mygj2nd4 1986 3 by by IN cord-009571-mygj2nd4 1986 4 NIH NIH NNP cord-009571-mygj2nd4 1986 5 grant grant NN cord-009571-mygj2nd4 1986 6 AM16209 am16209 NN cord-009571-mygj2nd4 1986 7 . . . cord-009571-mygj2nd4 1986 8 ) ) -RRB- cord-009571-mygj2nd4 1987 1 half half NN cord-009571-mygj2nd4 1987 2 of of IN cord-009571-mygj2nd4 1987 3 the the DT cord-009571-mygj2nd4 1987 4 girls girl NNS cord-009571-mygj2nd4 1987 5 . . . cord-009571-mygj2nd4 1988 1 Intervals interval NNS cord-009571-mygj2nd4 1988 2 between between IN cord-009571-mygj2nd4 1988 3 onset onset NN cord-009571-mygj2nd4 1988 4 of of IN cord-009571-mygj2nd4 1988 5 symptoms symptom NNS cord-009571-mygj2nd4 1988 6 and and CC cord-009571-mygj2nd4 1988 7 diagnosis diagnosis NN cord-009571-mygj2nd4 1988 8 ranged range VBD cord-009571-mygj2nd4 1988 9 between between IN cord-009571-mygj2nd4 1988 10 1 1 CD cord-009571-mygj2nd4 1988 11 month month NN cord-009571-mygj2nd4 1988 12 and and CC cord-009571-mygj2nd4 1988 13 10 10 CD cord-009571-mygj2nd4 1988 14 years year NNS cord-009571-mygj2nd4 1988 15 ( ( -LRB- cord-009571-mygj2nd4 1988 16 median median JJ cord-009571-mygj2nd4 1988 17 3 3 CD cord-009571-mygj2nd4 1988 18 months month NNS cord-009571-mygj2nd4 1988 19 ) ) -RRB- cord-009571-mygj2nd4 1988 20 . . . cord-009571-mygj2nd4 1989 1 Twenty twenty CD cord-009571-mygj2nd4 1989 2 - - HYPH cord-009571-mygj2nd4 1989 3 eight eight CD cord-009571-mygj2nd4 1989 4 children child NNS cord-009571-mygj2nd4 1989 5 were be VBD cord-009571-mygj2nd4 1989 6 white white JJ cord-009571-mygj2nd4 1989 7 , , , cord-009571-mygj2nd4 1989 8 5 5 CD cord-009571-mygj2nd4 1989 9 black black JJ cord-009571-mygj2nd4 1989 10 , , , cord-009571-mygj2nd4 1989 11 6 6 CD cord-009571-mygj2nd4 1989 12 native native JJ cord-009571-mygj2nd4 1989 13 American American NNP cord-009571-mygj2nd4 1989 14 , , , cord-009571-mygj2nd4 1989 15 4 4 CD cord-009571-mygj2nd4 1989 16 Asian Asian NNP cord-009571-mygj2nd4 1989 17 , , , cord-009571-mygj2nd4 1989 18 and and CC cord-009571-mygj2nd4 1989 19 2 2 CD cord-009571-mygj2nd4 1989 20 of of IN cord-009571-mygj2nd4 1989 21 other other JJ cord-009571-mygj2nd4 1989 22 races race NNS cord-009571-mygj2nd4 1989 23 . . . cord-009571-mygj2nd4 1990 1 Most most RBS cord-009571-mygj2nd4 1990 2 frequent frequent JJ cord-009571-mygj2nd4 1990 3 presenting present VBG cord-009571-mygj2nd4 1990 4 findings finding NNS cord-009571-mygj2nd4 1990 5 were be VBD cord-009571-mygj2nd4 1990 6 fever fever NN cord-009571-mygj2nd4 1990 7 and and CC cord-009571-mygj2nd4 1990 8 malaise malaise NN cord-009571-mygj2nd4 1990 9 , , , cord-009571-mygj2nd4 1990 10 musculoskeletal musculoskeletal JJ cord-009571-mygj2nd4 1990 11 complaints complaint NNS cord-009571-mygj2nd4 1990 12 , , , cord-009571-mygj2nd4 1990 13 skin skin NN cord-009571-mygj2nd4 1990 14 rash rash NN cord-009571-mygj2nd4 1990 15 , , , cord-009571-mygj2nd4 1990 16 and and CC cord-009571-mygj2nd4 1990 17 renal renal JJ cord-009571-mygj2nd4 1990 18 disease disease NN cord-009571-mygj2nd4 1990 19 . . . cord-009571-mygj2nd4 1991 1 Unusual unusual JJ cord-009571-mygj2nd4 1991 2 presentations presentation NNS cord-009571-mygj2nd4 1991 3 included include VBD cord-009571-mygj2nd4 1991 4 cholecystitis cholecystitis NN cord-009571-mygj2nd4 1991 5 , , , cord-009571-mygj2nd4 1991 6 isolated isolate VBN cord-009571-mygj2nd4 1991 7 nephrotic nephrotic JJ cord-009571-mygj2nd4 1991 8 syndrome syndrome NN cord-009571-mygj2nd4 1991 9 , , , cord-009571-mygj2nd4 1991 10 and and CC cord-009571-mygj2nd4 1991 11 chorea chorea NN cord-009571-mygj2nd4 1991 12 . . . cord-009571-mygj2nd4 1992 1 Three three CD cord-009571-mygj2nd4 1992 2 patients patient NNS cord-009571-mygj2nd4 1992 3 presented present VBN cord-009571-mygj2nd4 1992 4 with with IN cord-009571-mygj2nd4 1992 5 isolated isolated JJ cord-009571-mygj2nd4 1992 6 thrombocytopenia thrombocytopenia NN cord-009571-mygj2nd4 1992 7 . . . cord-009571-mygj2nd4 1993 1 Serious serious JJ cord-009571-mygj2nd4 1993 2 pulmonary pulmonary JJ cord-009571-mygj2nd4 1993 3 manifestations manifestation NNS cord-009571-mygj2nd4 1993 4 occurred occur VBD cord-009571-mygj2nd4 1993 5 in in IN cord-009571-mygj2nd4 1993 6 5 5 CD cord-009571-mygj2nd4 1993 7 patients patient NNS cord-009571-mygj2nd4 1993 8 ; ; : cord-009571-mygj2nd4 1993 9 2 2 CD cord-009571-mygj2nd4 1993 10 died die VBD cord-009571-mygj2nd4 1993 11 within within IN cord-009571-mygj2nd4 1993 12 2 2 CD cord-009571-mygj2nd4 1993 13 months month NNS cord-009571-mygj2nd4 1993 14 of of IN cord-009571-mygj2nd4 1993 15 disease disease NN cord-009571-mygj2nd4 1993 16 onset onset NN cord-009571-mygj2nd4 1993 17 . . . cord-009571-mygj2nd4 1994 1 Clinical clinical JJ cord-009571-mygj2nd4 1994 2 evidence evidence NN cord-009571-mygj2nd4 1994 3 of of IN cord-009571-mygj2nd4 1994 4 nephritis nephritis NN cord-009571-mygj2nd4 1994 5 occurred occur VBD cord-009571-mygj2nd4 1994 6 in in IN cord-009571-mygj2nd4 1994 7 9 9 CD cord-009571-mygj2nd4 1994 8 of of IN cord-009571-mygj2nd4 1994 9 1 1 CD cord-009571-mygj2nd4 1994 10 1 1 CD cord-009571-mygj2nd4 1994 11 boys boy NNS cord-009571-mygj2nd4 1994 12 and and CC cord-009571-mygj2nd4 1994 13 25 25 CD cord-009571-mygj2nd4 1994 14 of of IN cord-009571-mygj2nd4 1994 15 34 34 CD cord-009571-mygj2nd4 1994 16 girls girl NNS cord-009571-mygj2nd4 1994 17 . . . cord-009571-mygj2nd4 1995 1 Thirty thirty CD cord-009571-mygj2nd4 1995 2 - - HYPH cord-009571-mygj2nd4 1995 3 six six CD cord-009571-mygj2nd4 1995 4 patients patient NNS cord-009571-mygj2nd4 1995 5 had have VBD cord-009571-mygj2nd4 1995 6 1 1 CD cord-009571-mygj2nd4 1995 7 or or CC cord-009571-mygj2nd4 1995 8 more more JJR cord-009571-mygj2nd4 1995 9 renal renal JJ cord-009571-mygj2nd4 1995 10 biopsies biopsy NNS cord-009571-mygj2nd4 1995 11 . . . cord-009571-mygj2nd4 1996 1 Three three CD cord-009571-mygj2nd4 1996 2 patients patient NNS cord-009571-mygj2nd4 1996 3 with with IN cord-009571-mygj2nd4 1996 4 normal normal JJ cord-009571-mygj2nd4 1996 5 urinalyses urinalysis NNS cord-009571-mygj2nd4 1996 6 had have VBD cord-009571-mygj2nd4 1996 7 histologic histologic JJ cord-009571-mygj2nd4 1996 8 nephritis nephritis NN cord-009571-mygj2nd4 1996 9 by by IN cord-009571-mygj2nd4 1996 10 biopsy biopsy NN cord-009571-mygj2nd4 1996 11 . . . cord-009571-mygj2nd4 1997 1 Therapy therapy NN cord-009571-mygj2nd4 1997 2 consisted consist VBD cord-009571-mygj2nd4 1997 3 of of IN cord-009571-mygj2nd4 1997 4 prednisone prednisone NNP cord-009571-mygj2nd4 1997 5 ( ( -LRB- cord-009571-mygj2nd4 1997 6 41 41 CD cord-009571-mygj2nd4 1997 7 of of IN cord-009571-mygj2nd4 1997 8 45 45 CD cord-009571-mygj2nd4 1997 9 patients patient NNS cord-009571-mygj2nd4 1997 10 ) ) -RRB- cord-009571-mygj2nd4 1997 11 and and CC cord-009571-mygj2nd4 1997 12 either either CC cord-009571-mygj2nd4 1997 13 azathioprine azathioprine NN cord-009571-mygj2nd4 1997 14 or or CC cord-009571-mygj2nd4 1997 15 chlorambucil chlorambucil NNP cord-009571-mygj2nd4 1997 16 ( ( -LRB- cord-009571-mygj2nd4 1997 17 21 21 CD cord-009571-mygj2nd4 1997 18 of of IN cord-009571-mygj2nd4 1997 19 45 45 CD cord-009571-mygj2nd4 1997 20 patients patient NNS cord-009571-mygj2nd4 1997 21 ) ) -RRB- cord-009571-mygj2nd4 1997 22 . . . cord-009571-mygj2nd4 1998 1 Since since IN cord-009571-mygj2nd4 1998 2 1969 1969 CD cord-009571-mygj2nd4 1998 3 therapy therapy NN cord-009571-mygj2nd4 1998 4 has have VBZ cord-009571-mygj2nd4 1998 5 been be VBN cord-009571-mygj2nd4 1998 6 geared gear VBN cord-009571-mygj2nd4 1998 7 to to IN cord-009571-mygj2nd4 1998 8 normalizing normalize VBG cord-009571-mygj2nd4 1998 9 serum serum NN cord-009571-mygj2nd4 1998 10 hemolytic hemolytic JJ cord-009571-mygj2nd4 1998 11 complement complement NN cord-009571-mygj2nd4 1998 12 values value NNS cord-009571-mygj2nd4 1998 13 as as RB cord-009571-mygj2nd4 1998 14 well well RB cord-009571-mygj2nd4 1998 15 as as IN cord-009571-mygj2nd4 1998 16 controlling control VBG cord-009571-mygj2nd4 1998 17 clinical clinical JJ cord-009571-mygj2nd4 1998 18 manifestations manifestation NNS cord-009571-mygj2nd4 1998 19 of of IN cord-009571-mygj2nd4 1998 20 disease disease NN cord-009571-mygj2nd4 1998 21 . . . cord-009571-mygj2nd4 1999 1 Chronic chronic JJ cord-009571-mygj2nd4 1999 2 renal renal JJ cord-009571-mygj2nd4 1999 3 failure failure NN cord-009571-mygj2nd4 1999 4 developed develop VBN cord-009571-mygj2nd4 1999 5 in in IN cord-009571-mygj2nd4 1999 6 4 4 CD cord-009571-mygj2nd4 1999 7 patients patient NNS cord-009571-mygj2nd4 1999 8 ; ; : cord-009571-mygj2nd4 1999 9 only only RB cord-009571-mygj2nd4 1999 10 1 1 CD cord-009571-mygj2nd4 1999 11 had have VBD cord-009571-mygj2nd4 1999 12 had have VBN cord-009571-mygj2nd4 1999 13 adequate adequate JJ cord-009571-mygj2nd4 1999 14 therapy therapy NN cord-009571-mygj2nd4 1999 15 early early RB cord-009571-mygj2nd4 1999 16 in in IN cord-009571-mygj2nd4 1999 17 disease disease NN cord-009571-mygj2nd4 1999 18 . . . cord-009571-mygj2nd4 2000 1 One one CD cord-009571-mygj2nd4 2000 2 renal renal JJ cord-009571-mygj2nd4 2000 3 failure failure NN cord-009571-mygj2nd4 2000 4 patient patient NN cord-009571-mygj2nd4 2000 5 received receive VBD cord-009571-mygj2nd4 2000 6 a a DT cord-009571-mygj2nd4 2000 7 renal renal JJ cord-009571-mygj2nd4 2000 8 transplant transplant NN cord-009571-mygj2nd4 2000 9 , , , cord-009571-mygj2nd4 2000 10 and and CC cord-009571-mygj2nd4 2000 11 2 2 CD cord-009571-mygj2nd4 2000 12 are be VBP cord-009571-mygj2nd4 2000 13 on on IN cord-009571-mygj2nd4 2000 14 hemodialysis hemodialysis NN cord-009571-mygj2nd4 2000 15 . . . cord-009571-mygj2nd4 2001 1 Six six CD cord-009571-mygj2nd4 2001 2 girls girl NNS cord-009571-mygj2nd4 2001 3 and and CC cord-009571-mygj2nd4 2001 4 3 3 CD cord-009571-mygj2nd4 2001 5 boys boy NNS cord-009571-mygj2nd4 2001 6 have have VBP cord-009571-mygj2nd4 2001 7 died die VBN cord-009571-mygj2nd4 2001 8 ( ( -LRB- cord-009571-mygj2nd4 2001 9 209'0 209'0 CD cord-009571-mygj2nd4 2001 10 ) ) -RRB- cord-009571-mygj2nd4 2001 11 . . . cord-009571-mygj2nd4 2002 1 Seven seven CD cord-009571-mygj2nd4 2002 2 patients patient NNS cord-009571-mygj2nd4 2002 3 had have VBD cord-009571-mygj2nd4 2002 4 active active JJ cord-009571-mygj2nd4 2002 5 lupus lupus NN cord-009571-mygj2nd4 2002 6 at at IN cord-009571-mygj2nd4 2002 7 time time NN cord-009571-mygj2nd4 2002 8 of of IN cord-009571-mygj2nd4 2002 9 death death NN cord-009571-mygj2nd4 2002 10 with with IN cord-009571-mygj2nd4 2002 11 severe severe JJ cord-009571-mygj2nd4 2002 12 uncontrolled uncontrolled JJ cord-009571-mygj2nd4 2002 13 multisystem multisystem JJ cord-009571-mygj2nd4 2002 14 lupus lupus NN cord-009571-mygj2nd4 2002 15 ( ( -LRB- cord-009571-mygj2nd4 2002 16 3 3 CD cord-009571-mygj2nd4 2002 17 ) ) -RRB- cord-009571-mygj2nd4 2002 18 , , , cord-009571-mygj2nd4 2002 19 pulmonary pulmonary JJ cord-009571-mygj2nd4 2002 20 lupus lupus NN cord-009571-mygj2nd4 2002 21 ( ( -LRB- cord-009571-mygj2nd4 2002 22 2 2 CD cord-009571-mygj2nd4 2002 23 ) ) -RRB- cord-009571-mygj2nd4 2002 24 , , , cord-009571-mygj2nd4 2002 25 central central JJ cord-009571-mygj2nd4 2002 26 nervous nervous JJ cord-009571-mygj2nd4 2002 27 system system NN cord-009571-mygj2nd4 2002 28 lupus lupus NN cord-009571-mygj2nd4 2002 29 ( ( -LRB- cord-009571-mygj2nd4 2002 30 l l NNP cord-009571-mygj2nd4 2002 31 ) ) -RRB- cord-009571-mygj2nd4 2002 32 , , , cord-009571-mygj2nd4 2002 33 and and CC cord-009571-mygj2nd4 2002 34 renal renal JJ cord-009571-mygj2nd4 2002 35 failure failure NN cord-009571-mygj2nd4 2002 36 ( ( -LRB- cord-009571-mygj2nd4 2002 37 1 1 CD cord-009571-mygj2nd4 2002 38 ) ) -RRB- cord-009571-mygj2nd4 2002 39 . . . cord-009571-mygj2nd4 2003 1 One one CD cord-009571-mygj2nd4 2003 2 patient patient JJ cord-009571-mygj2nd4 2003 3 with with IN cord-009571-mygj2nd4 2003 4 active active JJ cord-009571-mygj2nd4 2003 5 SLE SLE NNP cord-009571-mygj2nd4 2003 6 also also RB cord-009571-mygj2nd4 2003 7 had have VBD cord-009571-mygj2nd4 2003 8 a a DT cord-009571-mygj2nd4 2003 9 myocardial myocardial JJ cord-009571-mygj2nd4 2003 10 infarction infarction NN cord-009571-mygj2nd4 2003 11 ( ( -LRB- cord-009571-mygj2nd4 2003 12 age age NN cord-009571-mygj2nd4 2003 13 7 7 CD cord-009571-mygj2nd4 2003 14 ) ) -RRB- cord-009571-mygj2nd4 2003 15 as as IN cord-009571-mygj2nd4 2003 16 a a DT cord-009571-mygj2nd4 2003 17 contributing contribute VBG cord-009571-mygj2nd4 2003 18 cause cause NN cord-009571-mygj2nd4 2003 19 of of IN cord-009571-mygj2nd4 2003 20 death death NN cord-009571-mygj2nd4 2003 21 . . . cord-009571-mygj2nd4 2004 1 Two two CD cord-009571-mygj2nd4 2004 2 patients patient NNS cord-009571-mygj2nd4 2004 3 died die VBD cord-009571-mygj2nd4 2004 4 while while IN cord-009571-mygj2nd4 2004 5 in in IN cord-009571-mygj2nd4 2004 6 clinical clinical JJ cord-009571-mygj2nd4 2004 7 remission remission NN cord-009571-mygj2nd4 2004 8 , , , cord-009571-mygj2nd4 2004 9 1 1 CD cord-009571-mygj2nd4 2004 10 of of IN cord-009571-mygj2nd4 2004 11 a a DT cord-009571-mygj2nd4 2004 12 myocardial myocardial JJ cord-009571-mygj2nd4 2004 13 infarction infarction NN cord-009571-mygj2nd4 2004 14 ( ( -LRB- cord-009571-mygj2nd4 2004 15 age age NN cord-009571-mygj2nd4 2004 16 20 20 CD cord-009571-mygj2nd4 2004 17 ) ) -RRB- cord-009571-mygj2nd4 2004 18 and and CC cord-009571-mygj2nd4 2004 19 1 1 CD cord-009571-mygj2nd4 2004 20 of of IN cord-009571-mygj2nd4 2004 21 clostridial clostridial JJ cord-009571-mygj2nd4 2004 22 sepsis sepsis NN cord-009571-mygj2nd4 2004 23 with with IN cord-009571-mygj2nd4 2004 24 hemolysis hemolysis NN cord-009571-mygj2nd4 2004 25 . . . cord-009571-mygj2nd4 2005 1 Infection infection NN cord-009571-mygj2nd4 2005 2 played play VBD cord-009571-mygj2nd4 2005 3 a a DT cord-009571-mygj2nd4 2005 4 major major JJ cord-009571-mygj2nd4 2005 5 role role NN cord-009571-mygj2nd4 2005 6 in in IN cord-009571-mygj2nd4 2005 7 4 4 CD cord-009571-mygj2nd4 2005 8 deaths death NNS cord-009571-mygj2nd4 2005 9 ( ( -LRB- cord-009571-mygj2nd4 2005 10 fungal fungal JJ cord-009571-mygj2nd4 2005 11 brain brain NN cord-009571-mygj2nd4 2005 12 abscess abscess NN cord-009571-mygj2nd4 2005 13 , , , cord-009571-mygj2nd4 2005 14 acute acute JJ cord-009571-mygj2nd4 2005 15 staphylococcal staphylococcal JJ cord-009571-mygj2nd4 2005 16 endocarditis endocarditis NN cord-009571-mygj2nd4 2005 17 , , , cord-009571-mygj2nd4 2005 18 disseminated disseminate VBN cord-009571-mygj2nd4 2005 19 herpes herpes NN cord-009571-mygj2nd4 2005 20 infection infection NN cord-009571-mygj2nd4 2005 21 , , , cord-009571-mygj2nd4 2005 22 clostridial clostridial JJ cord-009571-mygj2nd4 2005 23 sepsis sepsis NN cord-009571-mygj2nd4 2005 24 ) ) -RRB- cord-009571-mygj2nd4 2005 25 . . . cord-009571-mygj2nd4 2006 1 Thirty thirty CD cord-009571-mygj2nd4 2006 2 - - HYPH cord-009571-mygj2nd4 2006 3 three three CD cord-009571-mygj2nd4 2006 4 patients patient NNS cord-009571-mygj2nd4 2006 5 continue continue VBP cord-009571-mygj2nd4 2006 6 to to TO cord-009571-mygj2nd4 2006 7 have have VB cord-009571-mygj2nd4 2006 8 active active JJ cord-009571-mygj2nd4 2006 9 SLE SLE NNP cord-009571-mygj2nd4 2006 10 requiring require VBG cord-009571-mygj2nd4 2006 11 treatment treatment NN cord-009571-mygj2nd4 2006 12 ; ; : cord-009571-mygj2nd4 2006 13 2 2 CD cord-009571-mygj2nd4 2006 14 are be VBP cord-009571-mygj2nd4 2006 15 in in IN cord-009571-mygj2nd4 2006 16 remission remission NN cord-009571-mygj2nd4 2006 17 and and CC cord-009571-mygj2nd4 2006 18 are be VBP cord-009571-mygj2nd4 2006 19 not not RB cord-009571-mygj2nd4 2006 20 on on IN cord-009571-mygj2nd4 2006 21 medications medication NNS cord-009571-mygj2nd4 2006 22 ; ; : cord-009571-mygj2nd4 2006 23 I -PRON- PRP cord-009571-mygj2nd4 2006 24 patient patient NN cord-009571-mygj2nd4 2006 25 was be VBD cord-009571-mygj2nd4 2006 26 unavailable unavailable JJ cord-009571-mygj2nd4 2006 27 for for IN cord-009571-mygj2nd4 2006 28 followup followup NN cord-009571-mygj2nd4 2006 29 in in IN cord-009571-mygj2nd4 2006 30 1978 1978 CD cord-009571-mygj2nd4 2006 31 . . . cord-009571-mygj2nd4 2007 1 In in IN cord-009571-mygj2nd4 2007 2 patients patient NNS cord-009571-mygj2nd4 2007 3 with with IN cord-009571-mygj2nd4 2007 4 systemic systemic JJ cord-009571-mygj2nd4 2007 5 lupus lupus NN cord-009571-mygj2nd4 2007 6 erythematosus erythematosus NN cord-009571-mygj2nd4 2007 7 ( ( -LRB- cord-009571-mygj2nd4 2007 8 SLE SLE NNP cord-009571-mygj2nd4 2007 9 ) ) -RRB- cord-009571-mygj2nd4 2007 10 , , , cord-009571-mygj2nd4 2007 11 abnormal abnormal JJ cord-009571-mygj2nd4 2007 12 unfractionated unfractionated JJ cord-009571-mygj2nd4 2007 13 lymphocyte lymphocyte NN cord-009571-mygj2nd4 2007 14 responses response NNS cord-009571-mygj2nd4 2007 15 to to IN cord-009571-mygj2nd4 2007 16 phytohemagglutinin phytohemagglutinin NNP cord-009571-mygj2nd4 2007 17 ( ( -LRB- cord-009571-mygj2nd4 2007 18 PHA PHA NNP cord-009571-mygj2nd4 2007 19 ) ) -RRB- cord-009571-mygj2nd4 2007 20 can can MD cord-009571-mygj2nd4 2007 21 be be VB cord-009571-mygj2nd4 2007 22 corrected correct VBN cord-009571-mygj2nd4 2007 23 by by IN cord-009571-mygj2nd4 2007 24 removal removal NN cord-009571-mygj2nd4 2007 25 of of IN cord-009571-mygj2nd4 2007 26 adherent adherent JJ cord-009571-mygj2nd4 2007 27 mononuclear mononuclear JJ cord-009571-mygj2nd4 2007 28 ( ( -LRB- cord-009571-mygj2nd4 2007 29 M M NNP cord-009571-mygj2nd4 2007 30 ) ) -RRB- cord-009571-mygj2nd4 2007 31 cells cell NNS cord-009571-mygj2nd4 2007 32 ( ( -LRB- cord-009571-mygj2nd4 2007 33 Arthritis arthritis NN cord-009571-mygj2nd4 2007 34 Rheum Rheum NNP cord-009571-mygj2nd4 2007 35 20127 20127 CD cord-009571-mygj2nd4 2007 36 , , , cord-009571-mygj2nd4 2007 37 1977 1977 CD cord-009571-mygj2nd4 2007 38 ) ) -RRB- cord-009571-mygj2nd4 2007 39 . . . cord-009571-mygj2nd4 2008 1 The the DT cord-009571-mygj2nd4 2008 2 present present JJ cord-009571-mygj2nd4 2008 3 study study NN cord-009571-mygj2nd4 2008 4 demonstrates demonstrate VBZ cord-009571-mygj2nd4 2008 5 that that IN cord-009571-mygj2nd4 2008 6 this this DT cord-009571-mygj2nd4 2008 7 abnormal abnormal JJ cord-009571-mygj2nd4 2008 8 response response NN cord-009571-mygj2nd4 2008 9 occurs occur VBZ cord-009571-mygj2nd4 2008 10 when when WRB cord-009571-mygj2nd4 2008 11 1 1 CD cord-009571-mygj2nd4 2008 12 ) ) -RRB- cord-009571-mygj2nd4 2008 13 autologous autologous JJ cord-009571-mygj2nd4 2008 14 adherent adherent JJ cord-009571-mygj2nd4 2008 15 mononuclear mononuclear NN cord-009571-mygj2nd4 2008 16 cells cell NNS cord-009571-mygj2nd4 2008 17 or or CC cord-009571-mygj2nd4 2008 18 2 2 CD cord-009571-mygj2nd4 2008 19 ) ) -RRB- cord-009571-mygj2nd4 2008 20 cell cell NN cord-009571-mygj2nd4 2008 21 - - HYPH cord-009571-mygj2nd4 2008 22 free free JJ cord-009571-mygj2nd4 2008 23 supernatant supernatant JJ cord-009571-mygj2nd4 2008 24 fluids fluid NNS cord-009571-mygj2nd4 2008 25 from from IN cord-009571-mygj2nd4 2008 26 autologous autologous JJ cord-009571-mygj2nd4 2008 27 and and CC cord-009571-mygj2nd4 2008 28 allogeneic allogeneic JJ cord-009571-mygj2nd4 2008 29 adherent adherent JJ cord-009571-mygj2nd4 2008 30 cells cell NNS cord-009571-mygj2nd4 2008 31 are be VBP cord-009571-mygj2nd4 2008 32 added add VBN cord-009571-mygj2nd4 2008 33 to to IN cord-009571-mygj2nd4 2008 34 T t NN cord-009571-mygj2nd4 2008 35 - - HYPH cord-009571-mygj2nd4 2008 36 cell cell NN cord-009571-mygj2nd4 2008 37 cultures culture NNS cord-009571-mygj2nd4 2008 38 , , , cord-009571-mygj2nd4 2008 39 and and CC cord-009571-mygj2nd4 2008 40 that that IN cord-009571-mygj2nd4 2008 41 3 3 CD cord-009571-mygj2nd4 2008 42 ) ) -RRB- cord-009571-mygj2nd4 2008 43 suppression suppression NN cord-009571-mygj2nd4 2008 44 does do VBZ cord-009571-mygj2nd4 2008 45 not not RB cord-009571-mygj2nd4 2008 46 occur occur VB cord-009571-mygj2nd4 2008 47 when when WRB cord-009571-mygj2nd4 2008 48 adherent adherent JJ cord-009571-mygj2nd4 2008 49 cells cell NNS cord-009571-mygj2nd4 2008 50 are be VBP cord-009571-mygj2nd4 2008 51 pre pre JJ cord-009571-mygj2nd4 2008 52 - - VBN cord-009571-mygj2nd4 2008 53 treated treat VBN cord-009571-mygj2nd4 2008 54 with with IN cord-009571-mygj2nd4 2008 55 indomethacin indomethacin NN cord-009571-mygj2nd4 2008 56 . . . cord-009571-mygj2nd4 2009 1 Ficoll Ficoll NNP cord-009571-mygj2nd4 2009 2 - - HYPH cord-009571-mygj2nd4 2009 3 Hypaque Hypaque NNP cord-009571-mygj2nd4 2009 4 ( ( -LRB- cord-009571-mygj2nd4 2009 5 FH FH NNP cord-009571-mygj2nd4 2009 6 ) ) -RRB- cord-009571-mygj2nd4 2009 7 separated separate VBD cord-009571-mygj2nd4 2009 8 peripheral peripheral JJ cord-009571-mygj2nd4 2009 9 blood blood NN cord-009571-mygj2nd4 2009 10 mononuclear mononuclear NN cord-009571-mygj2nd4 2009 11 cells cell NNS cord-009571-mygj2nd4 2009 12 from from IN cord-009571-mygj2nd4 2009 13 normals normal NNS cord-009571-mygj2nd4 2009 14 and and CC cord-009571-mygj2nd4 2009 15 from from IN cord-009571-mygj2nd4 2009 16 patients patient NNS cord-009571-mygj2nd4 2009 17 with with IN cord-009571-mygj2nd4 2009 18 SLE SLE NNP cord-009571-mygj2nd4 2009 19 were be VBD cord-009571-mygj2nd4 2009 20 further further RB cord-009571-mygj2nd4 2009 21 fractionated fractionate VBN cord-009571-mygj2nd4 2009 22 into into IN cord-009571-mygj2nd4 2009 23 T t NN cord-009571-mygj2nd4 2009 24 cells cell NNS cord-009571-mygj2nd4 2009 25 by by IN cord-009571-mygj2nd4 2009 26 passage passage NN cord-009571-mygj2nd4 2009 27 over over IN cord-009571-mygj2nd4 2009 28 an an DT cord-009571-mygj2nd4 2009 29 antihuman antihuman JJ cord-009571-mygj2nd4 2009 30 F(ab f(ab NN cord-009571-mygj2nd4 2009 31 ) ) -RRB- cord-009571-mygj2nd4 2009 32 , , , cord-009571-mygj2nd4 2009 33 column column NN cord-009571-mygj2nd4 2009 34 ( ( -LRB- cord-009571-mygj2nd4 2009 35 97 97 CD cord-009571-mygj2nd4 2009 36 % % NN cord-009571-mygj2nd4 2009 37 E E NNS cord-009571-mygj2nd4 2009 38 - - NNS cord-009571-mygj2nd4 2009 39 rosettes rosette NNS cord-009571-mygj2nd4 2009 40 ) ) -RRB- cord-009571-mygj2nd4 2009 41 and and CC cord-009571-mygj2nd4 2009 42 M M NNP cord-009571-mygj2nd4 2009 43 cells cell NNS cord-009571-mygj2nd4 2009 44 by by IN cord-009571-mygj2nd4 2009 45 plating plate VBG cord-009571-mygj2nd4 2009 46 on on IN cord-009571-mygj2nd4 2009 47 glass glass NN cord-009571-mygj2nd4 2009 48 ( ( -LRB- cord-009571-mygj2nd4 2009 49 88 88 CD cord-009571-mygj2nd4 2009 50 % % NN cord-009571-mygj2nd4 2009 51 peroxidase peroxidase NN cord-009571-mygj2nd4 2009 52 - - HYPH cord-009571-mygj2nd4 2009 53 staining stain VBG cord-009571-mygj2nd4 2009 54 ) ) -RRB- cord-009571-mygj2nd4 2009 55 . . . cord-009571-mygj2nd4 2010 1 Cell cell NN cord-009571-mygj2nd4 2010 2 number number NN cord-009571-mygj2nd4 2010 3 was be VBD cord-009571-mygj2nd4 2010 4 constant constant JJ cord-009571-mygj2nd4 2010 5 in in IN cord-009571-mygj2nd4 2010 6 all all DT cord-009571-mygj2nd4 2010 7 experiments experiment NNS cord-009571-mygj2nd4 2010 8 . . . cord-009571-mygj2nd4 2011 1 Supernatants supernatant NNS cord-009571-mygj2nd4 2011 2 from from IN cord-009571-mygj2nd4 2011 3 normal normal JJ cord-009571-mygj2nd4 2011 4 controls control NNS cord-009571-mygj2nd4 2011 5 and and CC cord-009571-mygj2nd4 2011 6 from from IN cord-009571-mygj2nd4 2011 7 SLE SLE NNP cord-009571-mygj2nd4 2011 8 patients patient NNS cord-009571-mygj2nd4 2011 9 were be VBD cord-009571-mygj2nd4 2011 10 obtained obtain VBN cord-009571-mygj2nd4 2011 11 after after IN cord-009571-mygj2nd4 2011 12 48 48 CD cord-009571-mygj2nd4 2011 13 hour hour NN cord-009571-mygj2nd4 2011 14 culture culture NN cord-009571-mygj2nd4 2011 15 of of IN cord-009571-mygj2nd4 2011 16 FH FH NNP cord-009571-mygj2nd4 2011 17 , , , cord-009571-mygj2nd4 2011 18 T T NNP cord-009571-mygj2nd4 2011 19 , , , cord-009571-mygj2nd4 2011 20 and and CC cord-009571-mygj2nd4 2011 21 M M NNP cord-009571-mygj2nd4 2011 22 cells cell NNS cord-009571-mygj2nd4 2011 23 in in IN cord-009571-mygj2nd4 2011 24 RPMI RPMI NNP cord-009571-mygj2nd4 2011 25 containing contain VBG cord-009571-mygj2nd4 2011 26 AB AB NNP cord-009571-mygj2nd4 2011 27 serum serum NN cord-009571-mygj2nd4 2011 28 . . . cord-009571-mygj2nd4 2012 1 Normal normal JJ cord-009571-mygj2nd4 2012 2 and and CC cord-009571-mygj2nd4 2012 3 SLE SLE NNP cord-009571-mygj2nd4 2012 4 T T NNP cord-009571-mygj2nd4 2012 5 cells cell NNS cord-009571-mygj2nd4 2012 6 were be VBD cord-009571-mygj2nd4 2012 7 tested test VBN cord-009571-mygj2nd4 2012 8 for for IN cord-009571-mygj2nd4 2012 9 PHA PHA NNP cord-009571-mygj2nd4 2012 10 response response NN cord-009571-mygj2nd4 2012 11 in in IN cord-009571-mygj2nd4 2012 12 the the DT cord-009571-mygj2nd4 2012 13 presence presence NN cord-009571-mygj2nd4 2012 14 and and CC cord-009571-mygj2nd4 2012 15 absence absence NN cord-009571-mygj2nd4 2012 16 of of IN cord-009571-mygj2nd4 2012 17 autologous autologous JJ cord-009571-mygj2nd4 2012 18 and and CC cord-009571-mygj2nd4 2012 19 allogeneic allogeneic IN cord-009571-mygj2nd4 2012 20 M M NNP cord-009571-mygj2nd4 2012 21 cells cell NNS cord-009571-mygj2nd4 2012 22 or or CC cord-009571-mygj2nd4 2012 23 cell cell NN cord-009571-mygj2nd4 2012 24 - - HYPH cord-009571-mygj2nd4 2012 25 free free JJ cord-009571-mygj2nd4 2012 26 su su NN cord-009571-mygj2nd4 2012 27 - - HYPH cord-009571-mygj2nd4 2012 28 pernatants pernatant NNS cord-009571-mygj2nd4 2012 29 from from IN cord-009571-mygj2nd4 2012 30 FH FH NNP cord-009571-mygj2nd4 2012 31 , , , cord-009571-mygj2nd4 2012 32 T T NNP cord-009571-mygj2nd4 2012 33 , , , cord-009571-mygj2nd4 2012 34 or or CC cord-009571-mygj2nd4 2012 35 M M NNP cord-009571-mygj2nd4 2012 36 - - HYPH cord-009571-mygj2nd4 2012 37 cells cell NNS cord-009571-mygj2nd4 2012 38 . . . cord-009571-mygj2nd4 2013 1 Autologous autologous JJ cord-009571-mygj2nd4 2013 2 but but CC cord-009571-mygj2nd4 2013 3 not not RB cord-009571-mygj2nd4 2013 4 allogeneic allogeneic IN cord-009571-mygj2nd4 2013 5 M M NNP cord-009571-mygj2nd4 2013 6 cells cell NNS cord-009571-mygj2nd4 2013 7 suppress suppress VBP cord-009571-mygj2nd4 2013 8 T t NN cord-009571-mygj2nd4 2013 9 cell cell NN cord-009571-mygj2nd4 2013 10 responses response NNS cord-009571-mygj2nd4 2013 11 . . . cord-009571-mygj2nd4 2014 1 Cell cell NN cord-009571-mygj2nd4 2014 2 - - HYPH cord-009571-mygj2nd4 2014 3 free free JJ cord-009571-mygj2nd4 2014 4 supernatants supernatant NNS cord-009571-mygj2nd4 2014 5 derived derive VBN cord-009571-mygj2nd4 2014 6 from from IN cord-009571-mygj2nd4 2014 7 M M NNP cord-009571-mygj2nd4 2014 8 cells cell NNS cord-009571-mygj2nd4 2014 9 of of IN cord-009571-mygj2nd4 2014 10 14 14 CD cord-009571-mygj2nd4 2014 11 consecutive consecutive JJ cord-009571-mygj2nd4 2014 12 experiments experiment NNS cord-009571-mygj2nd4 2014 13 with with IN cord-009571-mygj2nd4 2014 14 SLE SLE NNP cord-009571-mygj2nd4 2014 15 patients patient NNS cord-009571-mygj2nd4 2014 16 caused cause VBD cord-009571-mygj2nd4 2014 17 an an DT cord-009571-mygj2nd4 2014 18 average average JJ cord-009571-mygj2nd4 2014 19 44 44 CD cord-009571-mygj2nd4 2014 20 % % NN cord-009571-mygj2nd4 2014 21 suppression suppression NN cord-009571-mygj2nd4 2014 22 of of IN cord-009571-mygj2nd4 2014 23 normal normal JJ cord-009571-mygj2nd4 2014 24 T t NN cord-009571-mygj2nd4 2014 25 - - HYPH cord-009571-mygj2nd4 2014 26 cell cell NN cord-009571-mygj2nd4 2014 27 response response NN cord-009571-mygj2nd4 2014 28 to to IN cord-009571-mygj2nd4 2014 29 PHA PHA NNP cord-009571-mygj2nd4 2014 30 ( ( -LRB- cord-009571-mygj2nd4 2014 31 mean mean NNP cord-009571-mygj2nd4 2014 32 peak peak NNP cord-009571-mygj2nd4 2014 33 CPM CPM NNP cord-009571-mygj2nd4 2014 34 relative relative NN cord-009571-mygj2nd4 2014 35 to to IN cord-009571-mygj2nd4 2014 36 control control NN cord-009571-mygj2nd4 2014 37 ) ) -RRB- cord-009571-mygj2nd4 2014 38 . . . cord-009571-mygj2nd4 2015 1 Suppression suppression NN cord-009571-mygj2nd4 2015 2 was be VBD cord-009571-mygj2nd4 2015 3 not not RB cord-009571-mygj2nd4 2015 4 due due JJ cord-009571-mygj2nd4 2015 5 to to IN cord-009571-mygj2nd4 2015 6 media medium NNS cord-009571-mygj2nd4 2015 7 exhaustion exhaustion NN cord-009571-mygj2nd4 2015 8 . . . cord-009571-mygj2nd4 2016 1 Supernatants supernatant NNS cord-009571-mygj2nd4 2016 2 from from IN cord-009571-mygj2nd4 2016 3 normal normal JJ cord-009571-mygj2nd4 2016 4 M M NNP cord-009571-mygj2nd4 2016 5 cells cell NNS cord-009571-mygj2nd4 2016 6 caused cause VBD cord-009571-mygj2nd4 2016 7 an an DT cord-009571-mygj2nd4 2016 8 average average JJ cord-009571-mygj2nd4 2016 9 35 35 CD cord-009571-mygj2nd4 2016 10 % % NN cord-009571-mygj2nd4 2016 11 suppression suppression NN cord-009571-mygj2nd4 2016 12 . . . cord-009571-mygj2nd4 2017 1 Supernatants supernatant NNS cord-009571-mygj2nd4 2017 2 from from IN cord-009571-mygj2nd4 2017 3 both both CC cord-009571-mygj2nd4 2017 4 normal normal JJ cord-009571-mygj2nd4 2017 5 and and CC cord-009571-mygj2nd4 2017 6 SLE SLE NNP cord-009571-mygj2nd4 2017 7 T T NNP cord-009571-mygj2nd4 2017 8 cells cell NNS cord-009571-mygj2nd4 2017 9 did do VBD cord-009571-mygj2nd4 2017 10 not not RB cord-009571-mygj2nd4 2017 11 suppress suppress VB cord-009571-mygj2nd4 2017 12 either either CC cord-009571-mygj2nd4 2017 13 autologous autologous JJ cord-009571-mygj2nd4 2017 14 or or CC cord-009571-mygj2nd4 2017 15 allogeneic allogeneic IN cord-009571-mygj2nd4 2017 16 T t NN cord-009571-mygj2nd4 2017 17 - - HYPH cord-009571-mygj2nd4 2017 18 cell cell NN cord-009571-mygj2nd4 2017 19 responses response NNS cord-009571-mygj2nd4 2017 20 . . . cord-009571-mygj2nd4 2018 1 When when WRB cord-009571-mygj2nd4 2018 2 M m NN cord-009571-mygj2nd4 2018 3 cells cell NNS cord-009571-mygj2nd4 2018 4 of of IN cord-009571-mygj2nd4 2018 5 patients patient NNS cord-009571-mygj2nd4 2018 6 with with IN cord-009571-mygj2nd4 2018 7 SLE SLE NNP cord-009571-mygj2nd4 2018 8 were be VBD cord-009571-mygj2nd4 2018 9 cultured culture VBN cord-009571-mygj2nd4 2018 10 in in IN cord-009571-mygj2nd4 2018 11 the the DT cord-009571-mygj2nd4 2018 12 presence presence NN cord-009571-mygj2nd4 2018 13 of of IN cord-009571-mygj2nd4 2018 14 1 1 CD cord-009571-mygj2nd4 2018 15 pg pg NNP cord-009571-mygj2nd4 2018 16 indomethacin indomethacin NNP cord-009571-mygj2nd4 2018 17 / / SYM cord-009571-mygj2nd4 2018 18 ml ml XX cord-009571-mygj2nd4 2018 19 , , , cord-009571-mygj2nd4 2018 20 the the DT cord-009571-mygj2nd4 2018 21 obtained obtain VBN cord-009571-mygj2nd4 2018 22 supernatant supernatant NN cord-009571-mygj2nd4 2018 23 was be VBD cord-009571-mygj2nd4 2018 24 not not RB cord-009571-mygj2nd4 2018 25 inhibitory inhibitory JJ cord-009571-mygj2nd4 2018 26 . . . cord-009571-mygj2nd4 2019 1 The the DT cord-009571-mygj2nd4 2019 2 data datum NNS cord-009571-mygj2nd4 2019 3 indicate indicate VBP cord-009571-mygj2nd4 2019 4 that that IN cord-009571-mygj2nd4 2019 5 poor poor JJ cord-009571-mygj2nd4 2019 6 in in IN cord-009571-mygj2nd4 2019 7 vitro vitro FW cord-009571-mygj2nd4 2019 8 unfractionated unfractionated JJ cord-009571-mygj2nd4 2019 9 lymphocyte lymphocyte NN cord-009571-mygj2nd4 2019 10 response response NN cord-009571-mygj2nd4 2019 11 to to IN cord-009571-mygj2nd4 2019 12 PHA PHA NNP cord-009571-mygj2nd4 2019 13 in in IN cord-009571-mygj2nd4 2019 14 patients patient NNS cord-009571-mygj2nd4 2019 15 with with IN cord-009571-mygj2nd4 2019 16 SLE SLE NNP cord-009571-mygj2nd4 2019 17 is be VBZ cord-009571-mygj2nd4 2019 18 mediated mediate VBN cord-009571-mygj2nd4 2019 19 by by IN cord-009571-mygj2nd4 2019 20 a a DT cord-009571-mygj2nd4 2019 21 soluble soluble JJ cord-009571-mygj2nd4 2019 22 indomethacin indomethacin JJ cord-009571-mygj2nd4 2019 23 - - HYPH cord-009571-mygj2nd4 2019 24 sensitive sensitive JJ cord-009571-mygj2nd4 2019 25 product product NN cord-009571-mygj2nd4 2019 26 derived derive VBN cord-009571-mygj2nd4 2019 27 from from IN cord-009571-mygj2nd4 2019 28 the the DT cord-009571-mygj2nd4 2019 29 adherent adherent JJ cord-009571-mygj2nd4 2019 30 mononuclear mononuclear NN cord-009571-mygj2nd4 2019 31 cells cell NNS cord-009571-mygj2nd4 2019 32 , , , cord-009571-mygj2nd4 2019 33 possibly possibly RB cord-009571-mygj2nd4 2019 34 prostaglandin prostaglandin JJ cord-009571-mygj2nd4 2019 35 . . . cord-009571-mygj2nd4 2020 1 Since since IN cord-009571-mygj2nd4 2020 2 supernatants supernatant NNS cord-009571-mygj2nd4 2020 3 from from IN cord-009571-mygj2nd4 2020 4 normal normal JJ cord-009571-mygj2nd4 2020 5 adherent adherent JJ cord-009571-mygj2nd4 2020 6 cells cell NNS cord-009571-mygj2nd4 2020 7 were be VBD cord-009571-mygj2nd4 2020 8 also also RB cord-009571-mygj2nd4 2020 9 inhibitory inhibitory JJ cord-009571-mygj2nd4 2020 10 when when WRB cord-009571-mygj2nd4 2020 11 M m NN cord-009571-mygj2nd4 2020 12 - - HYPH cord-009571-mygj2nd4 2020 13 cell cell NN cord-009571-mygj2nd4 2020 14 concentration concentration NN cord-009571-mygj2nd4 2020 15 was be VBD cord-009571-mygj2nd4 2020 16 held hold VBN cord-009571-mygj2nd4 2020 17 constant constant JJ cord-009571-mygj2nd4 2020 18 , , , cord-009571-mygj2nd4 2020 19 it -PRON- PRP cord-009571-mygj2nd4 2020 20 is be VBZ cord-009571-mygj2nd4 2020 21 likely likely JJ cord-009571-mygj2nd4 2020 22 that that IN cord-009571-mygj2nd4 2020 23 the the DT cord-009571-mygj2nd4 2020 24 difference difference NN cord-009571-mygj2nd4 2020 25 between between IN cord-009571-mygj2nd4 2020 26 SLE SLE NNP cord-009571-mygj2nd4 2020 27 and and CC cord-009571-mygj2nd4 2020 28 normal normal JJ cord-009571-mygj2nd4 2020 29 lymphocyte lymphocyte NN cord-009571-mygj2nd4 2020 30 responses response NNS cord-009571-mygj2nd4 2020 31 is be VBZ cord-009571-mygj2nd4 2020 32 quantitative quantitative JJ cord-009571-mygj2nd4 2020 33 rather rather RB cord-009571-mygj2nd4 2020 34 than than IN cord-009571-mygj2nd4 2020 35 qualitative qualitative JJ cord-009571-mygj2nd4 2020 36 . . . cord-009571-mygj2nd4 2021 1 Renal renal JJ cord-009571-mygj2nd4 2021 2 crisis crisis NN cord-009571-mygj2nd4 2021 3 in in IN cord-009571-mygj2nd4 2021 4 scleroderma scleroderma NN cord-009571-mygj2nd4 2021 5 , , , cord-009571-mygj2nd4 2021 6 with with IN cord-009571-mygj2nd4 2021 7 malignant malignant JJ cord-009571-mygj2nd4 2021 8 hypertension hypertension NN cord-009571-mygj2nd4 2021 9 and and CC cord-009571-mygj2nd4 2021 10 rapidly rapidly RB cord-009571-mygj2nd4 2021 11 progressive progressive JJ cord-009571-mygj2nd4 2021 12 renal renal JJ cord-009571-mygj2nd4 2021 13 failure failure NN cord-009571-mygj2nd4 2021 14 , , , cord-009571-mygj2nd4 2021 15 is be VBZ cord-009571-mygj2nd4 2021 16 perhaps perhaps RB cord-009571-mygj2nd4 2021 17 the the DT cord-009571-mygj2nd4 2021 18 most most RBS cord-009571-mygj2nd4 2021 19 ominous ominous JJ cord-009571-mygj2nd4 2021 20 of of IN cord-009571-mygj2nd4 2021 21 clinical clinical JJ cord-009571-mygj2nd4 2021 22 syndromes syndrome NNS cord-009571-mygj2nd4 2021 23 in in IN cord-009571-mygj2nd4 2021 24 the the DT cord-009571-mygj2nd4 2021 25 rheumatic rheumatic JJ cord-009571-mygj2nd4 2021 26 diseases disease NNS cord-009571-mygj2nd4 2021 27 . . . cord-009571-mygj2nd4 2022 1 Survival survival NN cord-009571-mygj2nd4 2022 2 with with IN cord-009571-mygj2nd4 2022 3 medical medical JJ cord-009571-mygj2nd4 2022 4 management management NN cord-009571-mygj2nd4 2022 5 has have VBZ cord-009571-mygj2nd4 2022 6 not not RB cord-009571-mygj2nd4 2022 7 been be VBN cord-009571-mygj2nd4 2022 8 reported report VBN cord-009571-mygj2nd4 2022 9 , , , cord-009571-mygj2nd4 2022 10 although although IN cord-009571-mygj2nd4 2022 11 a a DT cord-009571-mygj2nd4 2022 12 few few JJ cord-009571-mygj2nd4 2022 13 patients patient NNS cord-009571-mygj2nd4 2022 14 have have VBP cord-009571-mygj2nd4 2022 15 survived survive VBN cord-009571-mygj2nd4 2022 16 with with IN cord-009571-mygj2nd4 2022 17 renal renal JJ cord-009571-mygj2nd4 2022 18 dialysis dialysis NN cord-009571-mygj2nd4 2022 19 or or CC cord-009571-mygj2nd4 2022 20 transplantation transplantation NN cord-009571-mygj2nd4 2022 21 . . . cord-009571-mygj2nd4 2023 1 We -PRON- PRP cord-009571-mygj2nd4 2023 2 report report VBP cord-009571-mygj2nd4 2023 3 3 3 CD cord-009571-mygj2nd4 2023 4 patients patient NNS cord-009571-mygj2nd4 2023 5 surviving survive VBG cord-009571-mygj2nd4 2023 6 scleroderma scleroderma NN cord-009571-mygj2nd4 2023 7 kidney kidney NN cord-009571-mygj2nd4 2023 8 with with IN cord-009571-mygj2nd4 2023 9 medical medical JJ cord-009571-mygj2nd4 2023 10 management management NN cord-009571-mygj2nd4 2023 11 alone alone RB cord-009571-mygj2nd4 2023 12 for for IN cord-009571-mygj2nd4 2023 13 periods period NNS cord-009571-mygj2nd4 2023 14 of of IN cord-009571-mygj2nd4 2023 15 3,4 3,4 CD cord-009571-mygj2nd4 2023 16 , , , cord-009571-mygj2nd4 2023 17 and and CC cord-009571-mygj2nd4 2023 18 10 10 CD cord-009571-mygj2nd4 2023 19 years year NNS cord-009571-mygj2nd4 2023 20 . . . cord-009571-mygj2nd4 2024 1 Patient patient NN cord-009571-mygj2nd4 2024 2 1 1 CD cord-009571-mygj2nd4 2024 3 with with IN cord-009571-mygj2nd4 2024 4 malignant malignant JJ cord-009571-mygj2nd4 2024 5 hypertension hypertension NN cord-009571-mygj2nd4 2024 6 in in IN cord-009571-mygj2nd4 2024 7 the the DT cord-009571-mygj2nd4 2024 8 fourth fourth JJ cord-009571-mygj2nd4 2024 9 year year NN cord-009571-mygj2nd4 2024 10 of of IN cord-009571-mygj2nd4 2024 11 his -PRON- PRP$ cord-009571-mygj2nd4 2024 12 classic classic JJ cord-009571-mygj2nd4 2024 13 systemic systemic JJ cord-009571-mygj2nd4 2024 14 sclerosis sclerosis NN cord-009571-mygj2nd4 2024 15 was be VBD cord-009571-mygj2nd4 2024 16 hospitalized hospitalize VBN cord-009571-mygj2nd4 2024 17 with with IN cord-009571-mygj2nd4 2024 18 blood blood NN cord-009571-mygj2nd4 2024 19 pressure pressure NN cord-009571-mygj2nd4 2024 20 of of IN cord-009571-mygj2nd4 2024 21 220/ 220/ CD cord-009571-mygj2nd4 2024 22 140 140 CD cord-009571-mygj2nd4 2024 23 , , , cord-009571-mygj2nd4 2024 24 generalized generalized JJ cord-009571-mygj2nd4 2024 25 seizures seizure NNS cord-009571-mygj2nd4 2024 26 , , , cord-009571-mygj2nd4 2024 27 visual visual JJ cord-009571-mygj2nd4 2024 28 acuity acuity NN cord-009571-mygj2nd4 2024 29 decrease decrease NN cord-009571-mygj2nd4 2024 30 to to IN cord-009571-mygj2nd4 2024 31 virtual virtual JJ cord-009571-mygj2nd4 2024 32 blindness blindness NN cord-009571-mygj2nd4 2024 33 , , , cord-009571-mygj2nd4 2024 34 and and CC cord-009571-mygj2nd4 2024 35 striking strike VBG cord-009571-mygj2nd4 2024 36 grade grade NN cord-009571-mygj2nd4 2024 37 4 4 CD cord-009571-mygj2nd4 2024 38 hypertensive hypertensive JJ cord-009571-mygj2nd4 2024 39 retinopathy retinopathy NN cord-009571-mygj2nd4 2024 40 . . . cord-009571-mygj2nd4 2025 1 Creatinine creatinine NN cord-009571-mygj2nd4 2025 2 rose rise VBD cord-009571-mygj2nd4 2025 3 to to IN cord-009571-mygj2nd4 2025 4 a a DT cord-009571-mygj2nd4 2025 5 high high NN cord-009571-mygj2nd4 2025 6 of of IN cord-009571-mygj2nd4 2025 7 8.0 8.0 CD cord-009571-mygj2nd4 2025 8 . . . cord-009571-mygj2nd4 2026 1 Extraordinarily extraordinarily RB cord-009571-mygj2nd4 2026 2 vigorous vigorous JJ cord-009571-mygj2nd4 2026 3 antihypertensive antihypertensive JJ cord-009571-mygj2nd4 2026 4 treatment treatment NN cord-009571-mygj2nd4 2026 5 with with IN cord-009571-mygj2nd4 2026 6 massive massive JJ cord-009571-mygj2nd4 2026 7 doses dose NNS cord-009571-mygj2nd4 2026 8 of of IN cord-009571-mygj2nd4 2026 9 5 5 CD cord-009571-mygj2nd4 2026 10 drugs drug NNS cord-009571-mygj2nd4 2026 11 reduced reduce VBN cord-009571-mygj2nd4 2026 12 blood blood NN cord-009571-mygj2nd4 2026 13 pressure pressure NN cord-009571-mygj2nd4 2026 14 to to IN cord-009571-mygj2nd4 2026 15 low low JJ cord-009571-mygj2nd4 2026 16 normal normal JJ cord-009571-mygj2nd4 2026 17 ranges range NNS cord-009571-mygj2nd4 2026 18 . . . cord-009571-mygj2nd4 2027 1 Renal renal JJ cord-009571-mygj2nd4 2027 2 function function NN cord-009571-mygj2nd4 2027 3 4 4 CD cord-009571-mygj2nd4 2027 4 years year NNS cord-009571-mygj2nd4 2027 5 later later RB cord-009571-mygj2nd4 2027 6 is be VBZ cord-009571-mygj2nd4 2027 7 stable stable JJ cord-009571-mygj2nd4 2027 8 with with IN cord-009571-mygj2nd4 2027 9 a a DT cord-009571-mygj2nd4 2027 10 creatinine creatinine NN cord-009571-mygj2nd4 2027 11 of of IN cord-009571-mygj2nd4 2027 12 2.2 2.2 CD cord-009571-mygj2nd4 2027 13 mg mg CD cord-009571-mygj2nd4 2027 14 8 8 CD cord-009571-mygj2nd4 2027 15 . . . cord-009571-mygj2nd4 2028 1 Patient Patient NNP cord-009571-mygj2nd4 2028 2 2 2 CD cord-009571-mygj2nd4 2028 3 developed develop VBD cord-009571-mygj2nd4 2028 4 her -PRON- PRP$ cord-009571-mygj2nd4 2028 5 malignant malignant JJ cord-009571-mygj2nd4 2028 6 hypertension hypertension NN cord-009571-mygj2nd4 2028 7 after after IN cord-009571-mygj2nd4 2028 8 3 3 CD cord-009571-mygj2nd4 2028 9 years year NNS cord-009571-mygj2nd4 2028 10 of of IN cord-009571-mygj2nd4 2028 11 classic classic JJ cord-009571-mygj2nd4 2028 12 scleroderma scleroderma NNS cord-009571-mygj2nd4 2028 13 , , , cord-009571-mygj2nd4 2028 14 with with IN cord-009571-mygj2nd4 2028 15 blood blood NN cord-009571-mygj2nd4 2028 16 pressure pressure NN cord-009571-mygj2nd4 2028 17 200/130 200/130 CD cord-009571-mygj2nd4 2028 18 , , , cord-009571-mygj2nd4 2028 19 grade grade NN cord-009571-mygj2nd4 2028 20 3 3 CD cord-009571-mygj2nd4 2028 21 hypertensive hypertensive JJ cord-009571-mygj2nd4 2028 22 retinopathy retinopathy NN cord-009571-mygj2nd4 2028 23 , , , cord-009571-mygj2nd4 2028 24 generalized generalize VBN cord-009571-mygj2nd4 2028 25 seizures seizure NNS cord-009571-mygj2nd4 2028 26 , , , cord-009571-mygj2nd4 2028 27 a a DT cord-009571-mygj2nd4 2028 28 creatinine creatinine NN cord-009571-mygj2nd4 2028 29 of of IN cord-009571-mygj2nd4 2028 30 2.9 2.9 CD cord-009571-mygj2nd4 2028 31 , , , cord-009571-mygj2nd4 2028 32 and and CC cord-009571-mygj2nd4 2028 33 urine urine NN cord-009571-mygj2nd4 2028 34 protein protein NN cord-009571-mygj2nd4 2028 35 of of IN cord-009571-mygj2nd4 2028 36 2 2 CD cord-009571-mygj2nd4 2028 37 gms gms NN cord-009571-mygj2nd4 2028 38 per per IN cord-009571-mygj2nd4 2028 39 24 24 CD cord-009571-mygj2nd4 2028 40 hours hour NNS cord-009571-mygj2nd4 2028 41 . . . cord-009571-mygj2nd4 2029 1 Plasma plasma NN cord-009571-mygj2nd4 2029 2 renin renin NN cord-009571-mygj2nd4 2029 3 was be VBD cord-009571-mygj2nd4 2029 4 4400 4400 CD cord-009571-mygj2nd4 2029 5 ng ng NNP cord-009571-mygj2nd4 2029 6 / / SYM cord-009571-mygj2nd4 2029 7 dl dl NN cord-009571-mygj2nd4 2029 8 . . . cord-009571-mygj2nd4 2030 1 Aggressive aggressive JJ cord-009571-mygj2nd4 2030 2 antihypertensive antihypertensive JJ cord-009571-mygj2nd4 2030 3 treatment treatment NN cord-009571-mygj2nd4 2030 4 with with IN cord-009571-mygj2nd4 2030 5 5 5 CD cord-009571-mygj2nd4 2030 6 drugs drug NNS cord-009571-mygj2nd4 2030 7 reduced reduce VBN cord-009571-mygj2nd4 2030 8 blood blood NN cord-009571-mygj2nd4 2030 9 pressure pressure NN cord-009571-mygj2nd4 2030 10 to to IN cord-009571-mygj2nd4 2030 11 the the DT cord-009571-mygj2nd4 2030 12 low low JJ cord-009571-mygj2nd4 2030 13 normal normal JJ cord-009571-mygj2nd4 2030 14 range range NN cord-009571-mygj2nd4 2030 15 , , , cord-009571-mygj2nd4 2030 16 and and CC cord-009571-mygj2nd4 2030 17 over over IN cord-009571-mygj2nd4 2030 18 the the DT cord-009571-mygj2nd4 2030 19 following following JJ cord-009571-mygj2nd4 2030 20 3 3 CD cord-009571-mygj2nd4 2030 21 years year NNS cord-009571-mygj2nd4 2030 22 renal renal JJ cord-009571-mygj2nd4 2030 23 function function NN cord-009571-mygj2nd4 2030 24 has have VBZ cord-009571-mygj2nd4 2030 25 improved improve VBN cord-009571-mygj2nd4 2030 26 to to IN cord-009571-mygj2nd4 2030 27 a a DT cord-009571-mygj2nd4 2030 28 creatinine creatinine NN cord-009571-mygj2nd4 2030 29 of of IN cord-009571-mygj2nd4 2030 30 1.5 1.5 CD cord-009571-mygj2nd4 2030 31 . . . cord-009571-mygj2nd4 2031 1 Patient patient NN cord-009571-mygj2nd4 2031 2 3 3 CD cord-009571-mygj2nd4 2031 3 developed develop VBD cord-009571-mygj2nd4 2031 4 malignant malignant JJ cord-009571-mygj2nd4 2031 5 hypertension hypertension NN cord-009571-mygj2nd4 2031 6 after after IN cord-009571-mygj2nd4 2031 7 several several JJ cord-009571-mygj2nd4 2031 8 years year NNS cord-009571-mygj2nd4 2031 9 of of IN cord-009571-mygj2nd4 2031 10 classic classic JJ cord-009571-mygj2nd4 2031 11 scleroderma scleroderma NNS cord-009571-mygj2nd4 2031 12 . . . cord-009571-mygj2nd4 2032 1 Blood blood NN cord-009571-mygj2nd4 2032 2 pressure pressure NN cord-009571-mygj2nd4 2032 3 was be VBD cord-009571-mygj2nd4 2032 4 250/150 250/150 NN cord-009571-mygj2nd4 2032 5 , , , cord-009571-mygj2nd4 2032 6 creatinie creatinie NNP cord-009571-mygj2nd4 2032 7 rose rise VBD cord-009571-mygj2nd4 2032 8 to to IN cord-009571-mygj2nd4 2032 9 2.8 2.8 CD cord-009571-mygj2nd4 2032 10 , , , cord-009571-mygj2nd4 2032 11 hypertensive hypertensive JJ cord-009571-mygj2nd4 2032 12 grade grade NN cord-009571-mygj2nd4 2032 13 4 4 CD cord-009571-mygj2nd4 2032 14 eye eye NN cord-009571-mygj2nd4 2032 15 changes change NNS cord-009571-mygj2nd4 2032 16 were be VBD cord-009571-mygj2nd4 2032 17 noted note VBN cord-009571-mygj2nd4 2032 18 , , , cord-009571-mygj2nd4 2032 19 and and CC cord-009571-mygj2nd4 2032 20 renal renal JJ cord-009571-mygj2nd4 2032 21 biopsy biopsy NN cord-009571-mygj2nd4 2032 22 confirmed confirm VBD cord-009571-mygj2nd4 2032 23 afferent afferent JJ cord-009571-mygj2nd4 2032 24 arteriolar arteriolar JJ cord-009571-mygj2nd4 2032 25 necrosis necrosis NN cord-009571-mygj2nd4 2032 26 . . . cord-009571-mygj2nd4 2033 1 Hemorrhage hemorrhage NN cord-009571-mygj2nd4 2033 2 following follow VBG cord-009571-mygj2nd4 2033 3 renal renal JJ cord-009571-mygj2nd4 2033 4 biopsy biopsy NN cord-009571-mygj2nd4 2033 5 resulted result VBD cord-009571-mygj2nd4 2033 6 in in IN cord-009571-mygj2nd4 2033 7 transient transient JJ cord-009571-mygj2nd4 2033 8 hypotension hypotension NN cord-009571-mygj2nd4 2033 9 , , , cord-009571-mygj2nd4 2033 10 with with IN cord-009571-mygj2nd4 2033 11 subsequent subsequent JJ cord-009571-mygj2nd4 2033 12 control control NN cord-009571-mygj2nd4 2033 13 of of IN cord-009571-mygj2nd4 2033 14 blood blood NN cord-009571-mygj2nd4 2033 15 pressure pressure NN cord-009571-mygj2nd4 2033 16 in in IN cord-009571-mygj2nd4 2033 17 the the DT cord-009571-mygj2nd4 2033 18 low low JJ cord-009571-mygj2nd4 2033 19 normal normal JJ cord-009571-mygj2nd4 2033 20 range range NN cord-009571-mygj2nd4 2033 21 with with IN cord-009571-mygj2nd4 2033 22 combination combination NN cord-009571-mygj2nd4 2033 23 antihypertensive antihypertensive JJ cord-009571-mygj2nd4 2033 24 drug drug NN cord-009571-mygj2nd4 2033 25 therapy therapy NN cord-009571-mygj2nd4 2033 26 . . . cord-009571-mygj2nd4 2034 1 Her -PRON- PRP$ cord-009571-mygj2nd4 2034 2 renal renal JJ cord-009571-mygj2nd4 2034 3 function function NN cord-009571-mygj2nd4 2034 4 remains remain VBZ cord-009571-mygj2nd4 2034 5 stable stable JJ cord-009571-mygj2nd4 2034 6 with with IN cord-009571-mygj2nd4 2034 7 a a DT cord-009571-mygj2nd4 2034 8 creatinine creatinine NN cord-009571-mygj2nd4 2034 9 of of IN cord-009571-mygj2nd4 2034 10 1.5 1.5 CD cord-009571-mygj2nd4 2034 11 mg% mg% NNS cord-009571-mygj2nd4 2034 12 after after IN cord-009571-mygj2nd4 2034 13 10 10 CD cord-009571-mygj2nd4 2034 14 years year NNS cord-009571-mygj2nd4 2034 15 . . . cord-009571-mygj2nd4 2035 1 Skin skin NN cord-009571-mygj2nd4 2035 2 lesions lesion NNS cord-009571-mygj2nd4 2035 3 improved improve VBD cord-009571-mygj2nd4 2035 4 following follow VBG cord-009571-mygj2nd4 2035 5 hypertensive hypertensive JJ cord-009571-mygj2nd4 2035 6 control control NN cord-009571-mygj2nd4 2035 7 in in IN cord-009571-mygj2nd4 2035 8 2 2 CD cord-009571-mygj2nd4 2035 9 of of IN cord-009571-mygj2nd4 2035 10 these these DT cord-009571-mygj2nd4 2035 11 3 3 CD cord-009571-mygj2nd4 2035 12 patients patient NNS cord-009571-mygj2nd4 2035 13 . . . cord-009571-mygj2nd4 2036 1 The the DT cord-009571-mygj2nd4 2036 2 common common JJ cord-009571-mygj2nd4 2036 3 denominator denominator NN cord-009571-mygj2nd4 2036 4 in in IN cord-009571-mygj2nd4 2036 5 these these DT cord-009571-mygj2nd4 2036 6 3 3 CD cord-009571-mygj2nd4 2036 7 successfully successfully RB cord-009571-mygj2nd4 2036 8 managed manage VBD cord-009571-mygj2nd4 2036 9 patients patient NNS cord-009571-mygj2nd4 2036 10 appeared appear VBD cord-009571-mygj2nd4 2036 11 to to TO cord-009571-mygj2nd4 2036 12 be be VB cord-009571-mygj2nd4 2036 13 aggressive aggressive JJ cord-009571-mygj2nd4 2036 14 and and CC cord-009571-mygj2nd4 2036 15 determined determined JJ cord-009571-mygj2nd4 2036 16 reduction reduction NN cord-009571-mygj2nd4 2036 17 of of IN cord-009571-mygj2nd4 2036 18 blood blood NN cord-009571-mygj2nd4 2036 19 pressure pressure NN cord-009571-mygj2nd4 2036 20 to to IN cord-009571-mygj2nd4 2036 21 low low JJ cord-009571-mygj2nd4 2036 22 normal normal JJ cord-009571-mygj2nd4 2036 23 ranges range NNS cord-009571-mygj2nd4 2036 24 , , , cord-009571-mygj2nd4 2036 25 with with IN cord-009571-mygj2nd4 2036 26 later later JJ cord-009571-mygj2nd4 2036 27 reliance reliance NN cord-009571-mygj2nd4 2036 28 upon upon IN cord-009571-mygj2nd4 2036 29 propranolol propranolol NN cord-009571-mygj2nd4 2036 30 in in IN cord-009571-mygj2nd4 2036 31 2 2 CD cord-009571-mygj2nd4 2036 32 of of IN cord-009571-mygj2nd4 2036 33 the the DT cord-009571-mygj2nd4 2036 34 3 3 CD cord-009571-mygj2nd4 2036 35 patients patient NNS cord-009571-mygj2nd4 2036 36 . . . cord-009571-mygj2nd4 2037 1 The the DT cord-009571-mygj2nd4 2037 2 percentage percentage NN cord-009571-mygj2nd4 2037 3 of of IN cord-009571-mygj2nd4 2037 4 patients patient NNS cord-009571-mygj2nd4 2037 5 who who WP cord-009571-mygj2nd4 2037 6 will will MD cord-009571-mygj2nd4 2037 7 respond respond VB cord-009571-mygj2nd4 2037 8 to to IN cord-009571-mygj2nd4 2037 9 such such JJ cord-009571-mygj2nd4 2037 10 management management NN cord-009571-mygj2nd4 2037 11 is be VBZ cord-009571-mygj2nd4 2037 12 unknown unknown JJ cord-009571-mygj2nd4 2037 13 , , , cord-009571-mygj2nd4 2037 14 but but CC cord-009571-mygj2nd4 2037 15 aggressive aggressive JJ cord-009571-mygj2nd4 2037 16 early early JJ cord-009571-mygj2nd4 2037 17 treatment treatment NN cord-009571-mygj2nd4 2037 18 of of IN cord-009571-mygj2nd4 2037 19 hypertension hypertension NN cord-009571-mygj2nd4 2037 20 appears appear VBZ cord-009571-mygj2nd4 2037 21 indicated indicate VBN cord-009571-mygj2nd4 2037 22 . . . cord-009571-mygj2nd4 2038 1 The the DT cord-009571-mygj2nd4 2038 2 multi multi JJ cord-009571-mygj2nd4 2038 3 - - JJ cord-009571-mygj2nd4 2038 4 system system JJ cord-009571-mygj2nd4 2038 5 involvement involvement NN cord-009571-mygj2nd4 2038 6 and and CC cord-009571-mygj2nd4 2038 7 varied varied JJ cord-009571-mygj2nd4 2038 8 clinical clinical JJ cord-009571-mygj2nd4 2038 9 presentation presentation NN cord-009571-mygj2nd4 2038 10 of of IN cord-009571-mygj2nd4 2038 11 systemic systemic JJ cord-009571-mygj2nd4 2038 12 lupus lupus NN cord-009571-mygj2nd4 2038 13 erythematous erythematous JJ cord-009571-mygj2nd4 2038 14 ( ( -LRB- cord-009571-mygj2nd4 2038 15 SLE SLE NNP cord-009571-mygj2nd4 2038 16 ) ) -RRB- cord-009571-mygj2nd4 2038 17 make make VB cord-009571-mygj2nd4 2038 18 its -PRON- PRP$ cord-009571-mygj2nd4 2038 19 treatment treatment NN cord-009571-mygj2nd4 2038 20 difficult difficult JJ cord-009571-mygj2nd4 2038 21 and and CC cord-009571-mygj2nd4 2038 22 often often RB cord-009571-mygj2nd4 2038 23 controversial controversial JJ cord-009571-mygj2nd4 2038 24 . . . cord-009571-mygj2nd4 2039 1 To to TO cord-009571-mygj2nd4 2039 2 determine determine VB cord-009571-mygj2nd4 2039 3 present present JJ cord-009571-mygj2nd4 2039 4 clinical clinical JJ cord-009571-mygj2nd4 2039 5 practices practice NNS cord-009571-mygj2nd4 2039 6 , , , cord-009571-mygj2nd4 2039 7 200 200 CD cord-009571-mygj2nd4 2039 8 rheumatologists rheumatologist NNS cord-009571-mygj2nd4 2039 9 and and CC cord-009571-mygj2nd4 2039 10 nephrologists nephrologist NNS cord-009571-mygj2nd4 2039 11 , , , cord-009571-mygj2nd4 2039 12 selected select VBN cord-009571-mygj2nd4 2039 13 randomly randomly RB cord-009571-mygj2nd4 2039 14 from from IN cord-009571-mygj2nd4 2039 15 the the DT cord-009571-mygj2nd4 2039 16 Directory Directory NNP cord-009571-mygj2nd4 2039 17 of of IN cord-009571-mygj2nd4 2039 18 Medical Medical NNP cord-009571-mygj2nd4 2039 19 Specialists Specialists NNPS cord-009571-mygj2nd4 2039 20 , , , cord-009571-mygj2nd4 2039 21 were be VBD cord-009571-mygj2nd4 2039 22 surveyed survey VBN cord-009571-mygj2nd4 2039 23 for for IN cord-009571-mygj2nd4 2039 24 their -PRON- PRP$ cord-009571-mygj2nd4 2039 25 management management NN cord-009571-mygj2nd4 2039 26 practices practice NNS cord-009571-mygj2nd4 2039 27 for for IN cord-009571-mygj2nd4 2039 28 8 8 CD cord-009571-mygj2nd4 2039 29 hypothetical hypothetical JJ cord-009571-mygj2nd4 2039 30 SLE SLE NNP cord-009571-mygj2nd4 2039 31 patients patient NNS cord-009571-mygj2nd4 2039 32 . . . cord-009571-mygj2nd4 2040 1 Responding respond VBG cord-009571-mygj2nd4 2040 2 physicians physician NNS cord-009571-mygj2nd4 2040 3 follow follow VBP cord-009571-mygj2nd4 2040 4 over over IN cord-009571-mygj2nd4 2040 5 1900 1900 CD cord-009571-mygj2nd4 2040 6 patients patient NNS cord-009571-mygj2nd4 2040 7 with with IN cord-009571-mygj2nd4 2040 8 SLE SLE NNP cord-009571-mygj2nd4 2040 9 . . . cord-009571-mygj2nd4 2041 1 Patients patient NNS cord-009571-mygj2nd4 2041 2 were be VBD cord-009571-mygj2nd4 2041 3 managed manage VBN cord-009571-mygj2nd4 2041 4 as as IN cord-009571-mygj2nd4 2041 5 follows follow VBZ cord-009571-mygj2nd4 2041 6 : : : cord-009571-mygj2nd4 2041 7 ( ( -LRB- cord-009571-mygj2nd4 2041 8 1 1 LS cord-009571-mygj2nd4 2041 9 ) ) -RRB- cord-009571-mygj2nd4 2041 10 Joint joint NN cord-009571-mygj2nd4 2041 11 and and CC cord-009571-mygj2nd4 2041 12 skin skin NN cord-009571-mygj2nd4 2041 13 involvement involvement NN cord-009571-mygj2nd4 2041 14 only only RB cord-009571-mygj2nd4 2041 15 : : : cord-009571-mygj2nd4 2041 16 Ninety ninety CD cord-009571-mygj2nd4 2041 17 - - HYPH cord-009571-mygj2nd4 2041 18 four four CD cord-009571-mygj2nd4 2041 19 percent percent NN cord-009571-mygj2nd4 2041 20 of of IN cord-009571-mygj2nd4 2041 21 respondents respondent NNS cord-009571-mygj2nd4 2041 22 chose choose VBD cord-009571-mygj2nd4 2041 23 ASA ASA NNP cord-009571-mygj2nd4 2041 24 ( ( -LRB- cord-009571-mygj2nd4 2041 25 12 12 CD cord-009571-mygj2nd4 2041 26 - - SYM cord-009571-mygj2nd4 2041 27 16 16 CD cord-009571-mygj2nd4 2041 28 tabs tab NNS cord-009571-mygj2nd4 2041 29 / / SYM cord-009571-mygj2nd4 2041 30 day day NN cord-009571-mygj2nd4 2041 31 ) ) -RRB- cord-009571-mygj2nd4 2041 32 with with IN cord-009571-mygj2nd4 2041 33 9 9 CD cord-009571-mygj2nd4 2041 34 % % NN cord-009571-mygj2nd4 2041 35 also also RB cord-009571-mygj2nd4 2041 36 using use VBG cord-009571-mygj2nd4 2041 37 hydroxycholoroquin hydroxycholoroquin NNP cord-009571-mygj2nd4 2041 38 . . . cord-009571-mygj2nd4 2042 1 ( ( -LRB- cord-009571-mygj2nd4 2042 2 2 2 LS cord-009571-mygj2nd4 2042 3 ) ) -RRB- cord-009571-mygj2nd4 2042 4 Early early JJ cord-009571-mygj2nd4 2042 5 clinical clinical JJ cord-009571-mygj2nd4 2042 6 nephritis nephritis NN cord-009571-mygj2nd4 2042 7 : : : cord-009571-mygj2nd4 2042 8 Seventy seventy CD cord-009571-mygj2nd4 2042 9 - - HYPH cord-009571-mygj2nd4 2042 10 eight eight CD cord-009571-mygj2nd4 2042 11 percent percent NN cord-009571-mygj2nd4 2042 12 would would MD cord-009571-mygj2nd4 2042 13 initially initially RB cord-009571-mygj2nd4 2042 14 treat treat VB cord-009571-mygj2nd4 2042 15 with with IN cord-009571-mygj2nd4 2042 16 prednisone prednisone NN cord-009571-mygj2nd4 2042 17 , , , cord-009571-mygj2nd4 2042 18 usually usually RB cord-009571-mygj2nd4 2042 19 at at IN cord-009571-mygj2nd4 2042 20 about about RB cord-009571-mygj2nd4 2042 21 1 1 CD cord-009571-mygj2nd4 2042 22 mg/ mg/ NN cord-009571-mygj2nd4 2042 23 kg kg NNP cord-009571-mygj2nd4 2042 24 / / SYM cord-009571-mygj2nd4 2042 25 day day NN cord-009571-mygj2nd4 2042 26 but but CC cord-009571-mygj2nd4 2042 27 with with IN cord-009571-mygj2nd4 2042 28 25 25 CD cord-009571-mygj2nd4 2042 29 % % NN cord-009571-mygj2nd4 2042 30 choosing choose VBG cord-009571-mygj2nd4 2042 31 0.5 0.5 CD cord-009571-mygj2nd4 2042 32 mg mg NNP cord-009571-mygj2nd4 2042 33 / / SYM cord-009571-mygj2nd4 2042 34 kg kg NNP cord-009571-mygj2nd4 2042 35 . . . cord-009571-mygj2nd4 2043 1 ( ( -LRB- cord-009571-mygj2nd4 2043 2 3 3 LS cord-009571-mygj2nd4 2043 3 ) ) -RRB- cord-009571-mygj2nd4 2043 4 Active active JJ cord-009571-mygj2nd4 2043 5 nephritis nephritis NN cord-009571-mygj2nd4 2043 6 with with IN cord-009571-mygj2nd4 2043 7 rising rise VBG cord-009571-mygj2nd4 2043 8 creatinine creatinine NN cord-009571-mygj2nd4 2044 1 : : : cord-009571-mygj2nd4 2044 2 Ninety ninety CD cord-009571-mygj2nd4 2044 3 percent percent NN cord-009571-mygj2nd4 2044 4 would would MD cord-009571-mygj2nd4 2044 5 initially initially RB cord-009571-mygj2nd4 2044 6 employ employ VB cord-009571-mygj2nd4 2044 7 prednisone prednisone NN cord-009571-mygj2nd4 2044 8 , , , cord-009571-mygj2nd4 2044 9 at at IN cord-009571-mygj2nd4 2044 10 doses dose NNS cord-009571-mygj2nd4 2044 11 approximating approximate VBG cord-009571-mygj2nd4 2044 12 1 1 CD cord-009571-mygj2nd4 2044 13 mg mg NNP cord-009571-mygj2nd4 2044 14 / / SYM cord-009571-mygj2nd4 2044 15 kg kg NNP cord-009571-mygj2nd4 2044 16 , , , cord-009571-mygj2nd4 2044 17 and and CC cord-009571-mygj2nd4 2044 18 21 21 CD cord-009571-mygj2nd4 2044 19 % % NN cord-009571-mygj2nd4 2044 20 would would MD cord-009571-mygj2nd4 2044 21 also also RB cord-009571-mygj2nd4 2044 22 use use VB cord-009571-mygj2nd4 2044 23 immunosuppressives immunosuppressive NNS cord-009571-mygj2nd4 2044 24 . . . cord-009571-mygj2nd4 2045 1 ( ( -LRB- cord-009571-mygj2nd4 2045 2 4 4 LS cord-009571-mygj2nd4 2045 3 ) ) -RRB- cord-009571-mygj2nd4 2045 4 Serologicalfiare Serologicalfiare NNP cord-009571-mygj2nd4 2045 5 in in IN cord-009571-mygj2nd4 2045 6 an an DT cord-009571-mygj2nd4 2045 7 asymptomatic asymptomatic JJ cord-009571-mygj2nd4 2045 8 patient patient NN cord-009571-mygj2nd4 2045 9 : : : cord-009571-mygj2nd4 2045 10 Forty forty CD cord-009571-mygj2nd4 2045 11 - - HYPH cord-009571-mygj2nd4 2045 12 six six CD cord-009571-mygj2nd4 2045 13 percent percent NN cord-009571-mygj2nd4 2045 14 would would MD cord-009571-mygj2nd4 2045 15 treat treat VB cord-009571-mygj2nd4 2045 16 with with IN cord-009571-mygj2nd4 2045 17 prednisone prednisone NN cord-009571-mygj2nd4 2045 18 and and CC cord-009571-mygj2nd4 2045 19 51 51 CD cord-009571-mygj2nd4 2045 20 % % NN cord-009571-mygj2nd4 2045 21 would would MD cord-009571-mygj2nd4 2045 22 withhold withhold VB cord-009571-mygj2nd4 2045 23 treatment treatment NN cord-009571-mygj2nd4 2045 24 . . . cord-009571-mygj2nd4 2046 1 ( ( -LRB- cord-009571-mygj2nd4 2046 2 Three three CD cord-009571-mygj2nd4 2046 3 percent percent NN cord-009571-mygj2nd4 2046 4 demanded demand VBD cord-009571-mygj2nd4 2046 5 a a DT cord-009571-mygj2nd4 2046 6 renal renal JJ cord-009571-mygj2nd4 2046 7 biopsy biopsy NN cord-009571-mygj2nd4 2046 8 ) ) -RRB- cord-009571-mygj2nd4 2046 9 . . . cord-009571-mygj2nd4 2047 1 ( ( -LRB- cord-009571-mygj2nd4 2047 2 5 5 LS cord-009571-mygj2nd4 2047 3 ) ) -RRB- cord-009571-mygj2nd4 2047 4 Central central JJ cord-009571-mygj2nd4 2047 5 nervous nervous JJ cord-009571-mygj2nd4 2047 6 system system NN cord-009571-mygj2nd4 2047 7 SLE sle NN cord-009571-mygj2nd4 2047 8 : : : cord-009571-mygj2nd4 2047 9 Uniformly uniformly RB cord-009571-mygj2nd4 2047 10 treated treat VBN cord-009571-mygj2nd4 2047 11 with with IN cord-009571-mygj2nd4 2047 12 prednisone prednisone NNP cord-009571-mygj2nd4 2047 13 , , , cord-009571-mygj2nd4 2047 14 at at IN cord-009571-mygj2nd4 2047 15 least least JJS cord-009571-mygj2nd4 2047 16 1 1 CD cord-009571-mygj2nd4 2047 17 mg mg NNP cord-009571-mygj2nd4 2047 18 / / SYM cord-009571-mygj2nd4 2047 19 kg kg NNP cord-009571-mygj2nd4 2047 20 , , , cord-009571-mygj2nd4 2047 21 with with IN cord-009571-mygj2nd4 2047 22 23 23 CD cord-009571-mygj2nd4 2047 23 % % NN cord-009571-mygj2nd4 2047 24 also also RB cord-009571-mygj2nd4 2047 25 employing employ VBG cord-009571-mygj2nd4 2047 26 immunosuppressants immunosuppressant NNS cord-009571-mygj2nd4 2047 27 . . . cord-009571-mygj2nd4 2048 1 ( ( -LRB- cord-009571-mygj2nd4 2048 2 6 6 CD cord-009571-mygj2nd4 2048 3 ) ) -RRB- cord-009571-mygj2nd4 2049 1 Late late JJ cord-009571-mygj2nd4 2049 2 stage stage NN cord-009571-mygj2nd4 2049 3 arotemic arotemic JJ cord-009571-mygj2nd4 2049 4 in in IN cord-009571-mygj2nd4 2049 5 - - HYPH cord-009571-mygj2nd4 2049 6 active active JJ cord-009571-mygj2nd4 2049 7 SLE SLE NNP cord-009571-mygj2nd4 2049 8 : : : cord-009571-mygj2nd4 2049 9 Fifty fifty CD cord-009571-mygj2nd4 2049 10 - - HYPH cord-009571-mygj2nd4 2049 11 nine nine CD cord-009571-mygj2nd4 2049 12 percent percent NN cord-009571-mygj2nd4 2049 13 elected elect VBN cord-009571-mygj2nd4 2049 14 to to TO cord-009571-mygj2nd4 2049 15 treat treat VB cord-009571-mygj2nd4 2049 16 with with IN cord-009571-mygj2nd4 2049 17 prednisone prednisone NNP cord-009571-mygj2nd4 2049 18 . . . cord-009571-mygj2nd4 2050 1 ( ( -LRB- cord-009571-mygj2nd4 2050 2 7 7 CD cord-009571-mygj2nd4 2050 3 ) ) -RRB- cord-009571-mygj2nd4 2050 4 Prednisone Prednisone NNP cord-009571-mygj2nd4 2050 5 taperingpractices taperingpractice NNS cord-009571-mygj2nd4 2050 6 : : : cord-009571-mygj2nd4 2051 1 From from IN cord-009571-mygj2nd4 2051 2 a a DT cord-009571-mygj2nd4 2051 3 starting starting NN cord-009571-mygj2nd4 2051 4 dose dose NN cord-009571-mygj2nd4 2051 5 of of IN cord-009571-mygj2nd4 2051 6 60 60 CD cord-009571-mygj2nd4 2051 7 mg mg NNP cord-009571-mygj2nd4 2051 8 / / SYM cord-009571-mygj2nd4 2051 9 day day NN cord-009571-mygj2nd4 2051 10 , , , cord-009571-mygj2nd4 2051 11 physicians physician NNS cord-009571-mygj2nd4 2051 12 tapered taper VBD cord-009571-mygj2nd4 2051 13 to to IN cord-009571-mygj2nd4 2051 14 a a DT cord-009571-mygj2nd4 2051 15 mean mean NN cord-009571-mygj2nd4 2051 16 of of IN cord-009571-mygj2nd4 2051 17 33 33 CD cord-009571-mygj2nd4 2051 18 mg mg NNP cord-009571-mygj2nd4 2051 19 / / SYM cord-009571-mygj2nd4 2051 20 day day NN cord-009571-mygj2nd4 2051 21 after after IN cord-009571-mygj2nd4 2051 22 3 3 CD cord-009571-mygj2nd4 2051 23 months month NNS cord-009571-mygj2nd4 2051 24 and and CC cord-009571-mygj2nd4 2051 25 17 17 CD cord-009571-mygj2nd4 2051 26 mg mg NNP cord-009571-mygj2nd4 2051 27 / / SYM cord-009571-mygj2nd4 2051 28 day day NN cord-009571-mygj2nd4 2051 29 after after IN cord-009571-mygj2nd4 2051 30 6 6 CD cord-009571-mygj2nd4 2051 31 months month NNS cord-009571-mygj2nd4 2051 32 . . . cord-009571-mygj2nd4 2052 1 Thirty thirty CD cord-009571-mygj2nd4 2052 2 - - HYPH cord-009571-mygj2nd4 2052 3 three three CD cord-009571-mygj2nd4 2052 4 percent percent NN cord-009571-mygj2nd4 2052 5 used use VBD cord-009571-mygj2nd4 2052 6 a a DT cord-009571-mygj2nd4 2052 7 divided divided JJ cord-009571-mygj2nd4 2052 8 dose dose NN cord-009571-mygj2nd4 2052 9 initially initially RB cord-009571-mygj2nd4 2052 10 , , , cord-009571-mygj2nd4 2052 11 and and CC cord-009571-mygj2nd4 2052 12 57 57 CD cord-009571-mygj2nd4 2052 13 % % NN cord-009571-mygj2nd4 2052 14 used use VBN cord-009571-mygj2nd4 2052 15 alternate alternate JJ cord-009571-mygj2nd4 2052 16 day day NN cord-009571-mygj2nd4 2052 17 schedules schedule NNS cord-009571-mygj2nd4 2052 18 later later RB cord-009571-mygj2nd4 2052 19 . . . cord-009571-mygj2nd4 2053 1 ( ( -LRB- cord-009571-mygj2nd4 2053 2 8) 8) NNP cord-009571-mygj2nd4 2053 3 Flare Flare NNP cord-009571-mygj2nd4 2053 4 while while IN cord-009571-mygj2nd4 2053 5 tapering taper VBG cord-009571-mygj2nd4 2053 6 : : : cord-009571-mygj2nd4 2053 7 All all DT cord-009571-mygj2nd4 2053 8 physicians physician NNS cord-009571-mygj2nd4 2053 9 increased increase VBD cord-009571-mygj2nd4 2053 10 medication medication NN cord-009571-mygj2nd4 2053 11 , , , cord-009571-mygj2nd4 2053 12 with with IN cord-009571-mygj2nd4 2053 13 87 87 CD cord-009571-mygj2nd4 2053 14 % % NN cord-009571-mygj2nd4 2053 15 increasing increase VBG cord-009571-mygj2nd4 2053 16 prednisone prednisone NNP cord-009571-mygj2nd4 2053 17 dose dose NN cord-009571-mygj2nd4 2053 18 , , , cord-009571-mygj2nd4 2053 19 13 13 CD cord-009571-mygj2nd4 2053 20 % % NN cord-009571-mygj2nd4 2053 21 adding add VBG cord-009571-mygj2nd4 2053 22 an an DT cord-009571-mygj2nd4 2053 23 immunosuppressant immunosuppressant NN cord-009571-mygj2nd4 2053 24 , , , cord-009571-mygj2nd4 2053 25 and and CC cord-009571-mygj2nd4 2053 26 many many JJ cord-009571-mygj2nd4 2053 27 doing do VBG cord-009571-mygj2nd4 2053 28 both both DT cord-009571-mygj2nd4 2053 29 . . . cord-009571-mygj2nd4 2054 1 Rheumatologists Rheumatologists NNP cord-009571-mygj2nd4 2054 2 and and CC cord-009571-mygj2nd4 2054 3 nephrologists nephrologist NNS cord-009571-mygj2nd4 2054 4 were be VBD cord-009571-mygj2nd4 2054 5 similar similar JJ cord-009571-mygj2nd4 2054 6 in in IN cord-009571-mygj2nd4 2054 7 treatment treatment NN cord-009571-mygj2nd4 2054 8 of of IN cord-009571-mygj2nd4 2054 9 most most JJS cord-009571-mygj2nd4 2054 10 problems problem NNS cord-009571-mygj2nd4 2054 11 . . . cord-009571-mygj2nd4 2055 1 However however RB cord-009571-mygj2nd4 2055 2 , , , cord-009571-mygj2nd4 2055 3 nephrologists nephrologist NNS cord-009571-mygj2nd4 2055 4 used use VBD cord-009571-mygj2nd4 2055 5 immunosuppressive immunosuppressive JJ cord-009571-mygj2nd4 2055 6 agents agent NNS cord-009571-mygj2nd4 2055 7 twice twice RB cord-009571-mygj2nd4 2055 8 as as RB cord-009571-mygj2nd4 2055 9 frequently frequently RB cord-009571-mygj2nd4 2055 10 in in IN cord-009571-mygj2nd4 2055 11 early early JJ cord-009571-mygj2nd4 2055 12 disease disease NN cord-009571-mygj2nd4 2055 13 but but CC cord-009571-mygj2nd4 2055 14 treated treat VBN cord-009571-mygj2nd4 2055 15 late late JJ cord-009571-mygj2nd4 2055 16 stage stage NN cord-009571-mygj2nd4 2055 17 nephritis nephritis NN cord-009571-mygj2nd4 2055 18 less less RBR cord-009571-mygj2nd4 2055 19 vigorously vigorously RB cord-009571-mygj2nd4 2055 20 than than IN cord-009571-mygj2nd4 2055 21 did do VBD cord-009571-mygj2nd4 2055 22 rheumatologists rheumatologist NNS cord-009571-mygj2nd4 2055 23 . . . cord-009571-mygj2nd4 2056 1 Nephrologists Nephrologists NNP cord-009571-mygj2nd4 2056 2 also also RB cord-009571-mygj2nd4 2056 3 used use VBD cord-009571-mygj2nd4 2056 4 fewer few JJR cord-009571-mygj2nd4 2056 5 divided divide VBN cord-009571-mygj2nd4 2056 6 daily daily JJ cord-009571-mygj2nd4 2056 7 doses dose NNS cord-009571-mygj2nd4 2056 8 of of IN cord-009571-mygj2nd4 2056 9 prednisone prednisone NNP cord-009571-mygj2nd4 2056 10 and and CC cord-009571-mygj2nd4 2056 11 used use VBD cord-009571-mygj2nd4 2056 12 alternate alternate JJ cord-009571-mygj2nd4 2056 13 day day NN cord-009571-mygj2nd4 2056 14 schedule schedule NN cord-009571-mygj2nd4 2056 15 sooner soon RBR cord-009571-mygj2nd4 2056 16 and and CC cord-009571-mygj2nd4 2056 17 more more RBR cord-009571-mygj2nd4 2056 18 frequently frequently RB cord-009571-mygj2nd4 2056 19 . . . cord-009571-mygj2nd4 2057 1 Treatment treatment NN cord-009571-mygj2nd4 2057 2 was be VBD cord-009571-mygj2nd4 2057 3 highly highly RB cord-009571-mygj2nd4 2057 4 case case NN cord-009571-mygj2nd4 2057 5 specific specific JJ cord-009571-mygj2nd4 2057 6 . . . cord-009571-mygj2nd4 2058 1 Substantive substantive JJ cord-009571-mygj2nd4 2058 2 disagreement disagreement NN cord-009571-mygj2nd4 2058 3 occurred occur VBD cord-009571-mygj2nd4 2058 4 when when WRB cord-009571-mygj2nd4 2058 5 there there EX cord-009571-mygj2nd4 2058 6 was be VBD cord-009571-mygj2nd4 2058 7 serological serological JJ cord-009571-mygj2nd4 2058 8 disease disease NN cord-009571-mygj2nd4 2058 9 without without IN cord-009571-mygj2nd4 2058 10 clinical clinical JJ cord-009571-mygj2nd4 2058 11 disease disease NN cord-009571-mygj2nd4 2058 12 , , , cord-009571-mygj2nd4 2058 13 and and CC cord-009571-mygj2nd4 2058 14 in in IN cord-009571-mygj2nd4 2058 15 treatment treatment NN cord-009571-mygj2nd4 2058 16 of of IN cord-009571-mygj2nd4 2058 17 end end NN cord-009571-mygj2nd4 2058 18 - - HYPH cord-009571-mygj2nd4 2058 19 stage stage NN cord-009571-mygj2nd4 2058 20 nephritis nephritis NN cord-009571-mygj2nd4 2058 21 . . . cord-009571-mygj2nd4 2059 1 Central central JJ cord-009571-mygj2nd4 2059 2 nervous nervous JJ cord-009571-mygj2nd4 2059 3 system system NN cord-009571-mygj2nd4 2059 4 episodes episode NNS cord-009571-mygj2nd4 2059 5 and and CC cord-009571-mygj2nd4 2059 6 early early JJ cord-009571-mygj2nd4 2059 7 progressive progressive JJ cord-009571-mygj2nd4 2059 8 nephritis nephritis NN cord-009571-mygj2nd4 2059 9 were be VBD cord-009571-mygj2nd4 2059 10 uniformly uniformly RB cord-009571-mygj2nd4 2059 11 treated treat VBN cord-009571-mygj2nd4 2059 12 aggressively aggressively RB cord-009571-mygj2nd4 2059 13 . . . cord-009571-mygj2nd4 2060 1 Immunosuppressive immunosuppressive JJ cord-009571-mygj2nd4 2060 2 agents agent NNS cord-009571-mygj2nd4 2060 3 were be VBD cord-009571-mygj2nd4 2060 4 employed employ VBN cord-009571-mygj2nd4 2060 5 only only RB cord-009571-mygj2nd4 2060 6 by by IN cord-009571-mygj2nd4 2060 7 a a DT cord-009571-mygj2nd4 2060 8 minority minority NN cord-009571-mygj2nd4 2060 9 of of IN cord-009571-mygj2nd4 2060 10 respondents respondent NNS cord-009571-mygj2nd4 2060 11 . . . cord-009571-mygj2nd4 2061 1 Antibody antibody NN cord-009571-mygj2nd4 2061 2 - - HYPH cord-009571-mygj2nd4 2061 3 dependent dependent JJ cord-009571-mygj2nd4 2061 4 cell cell NN cord-009571-mygj2nd4 2061 5 - - HYPH cord-009571-mygj2nd4 2061 6 mediated mediate VBN cord-009571-mygj2nd4 2061 7 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 2061 8 ( ( -LRB- cord-009571-mygj2nd4 2061 9 ADCC ADCC NNP cord-009571-mygj2nd4 2061 10 ) ) -RRB- cord-009571-mygj2nd4 2061 11 was be VBD cord-009571-mygj2nd4 2061 12 studied study VBN cord-009571-mygj2nd4 2061 13 in in IN cord-009571-mygj2nd4 2061 14 adult adult NN cord-009571-mygj2nd4 2061 15 patients patient NNS cord-009571-mygj2nd4 2061 16 with with IN cord-009571-mygj2nd4 2061 17 rheumatoid rheumatoid NN cord-009571-mygj2nd4 2061 18 arthritis arthritis NN cord-009571-mygj2nd4 2061 19 ( ( -LRB- cord-009571-mygj2nd4 2061 20 RA RA NNP cord-009571-mygj2nd4 2061 21 ) ) -RRB- cord-009571-mygj2nd4 2061 22 and and CC cord-009571-mygj2nd4 2061 23 in in IN cord-009571-mygj2nd4 2061 24 healthy healthy JJ cord-009571-mygj2nd4 2061 25 controls control NNS cord-009571-mygj2nd4 2061 26 . . . cord-009571-mygj2nd4 2062 1 Three three CD cord-009571-mygj2nd4 2062 2 effector effector NN cord-009571-mygj2nd4 2062 3 cell cell NN cord-009571-mygj2nd4 2062 4 populations population NNS cord-009571-mygj2nd4 2062 5 from from IN cord-009571-mygj2nd4 2062 6 the the DT cord-009571-mygj2nd4 2062 7 peripheral peripheral JJ cord-009571-mygj2nd4 2062 8 blood blood NN cord-009571-mygj2nd4 2062 9 were be VBD cord-009571-mygj2nd4 2062 10 studied study VBN cord-009571-mygj2nd4 2062 11 . . . cord-009571-mygj2nd4 2063 1 These these DT cord-009571-mygj2nd4 2063 2 included include VBD cord-009571-mygj2nd4 2063 3 a a DT cord-009571-mygj2nd4 2063 4 mixed mixed JJ cord-009571-mygj2nd4 2063 5 mononuclear mononuclear JJ cord-009571-mygj2nd4 2063 6 population population NN cord-009571-mygj2nd4 2063 7 ( ( -LRB- cord-009571-mygj2nd4 2063 8 8 8 CD cord-009571-mygj2nd4 2063 9 - - SYM cord-009571-mygj2nd4 2063 10 12 12 CD cord-009571-mygj2nd4 2063 11 % % NN cord-009571-mygj2nd4 2063 12 latex latex NN cord-009571-mygj2nd4 2063 13 positive positive JJ cord-009571-mygj2nd4 2063 14 ) ) -RRB- cord-009571-mygj2nd4 2063 15 , , , cord-009571-mygj2nd4 2063 16 a a DT cord-009571-mygj2nd4 2063 17 monocyte monocyte NNP cord-009571-mygj2nd4 2063 18 - - HYPH cord-009571-mygj2nd4 2063 19 depleted deplete VBN cord-009571-mygj2nd4 2063 20 fraction fraction NN cord-009571-mygj2nd4 2063 21 ( ( -LRB- cord-009571-mygj2nd4 2063 22 less less JJR cord-009571-mygj2nd4 2063 23 than than IN cord-009571-mygj2nd4 2063 24 1 1 CD cord-009571-mygj2nd4 2063 25 % % NN cord-009571-mygj2nd4 2063 26 latex latex NN cord-009571-mygj2nd4 2063 27 positive positive JJ cord-009571-mygj2nd4 2063 28 ) ) -RRB- cord-009571-mygj2nd4 2063 29 , , , cord-009571-mygj2nd4 2063 30 and and CC cord-009571-mygj2nd4 2063 31 a a DT cord-009571-mygj2nd4 2063 32 monocyte monocyte NNP cord-009571-mygj2nd4 2063 33 enriched enrich VBN cord-009571-mygj2nd4 2063 34 fraction fraction NN cord-009571-mygj2nd4 2063 35 ( ( -LRB- cord-009571-mygj2nd4 2063 36 65 65 CD cord-009571-mygj2nd4 2063 37 - - SYM cord-009571-mygj2nd4 2063 38 80 80 CD cord-009571-mygj2nd4 2063 39 % % NN cord-009571-mygj2nd4 2063 40 latex latex NN cord-009571-mygj2nd4 2063 41 positive positive JJ cord-009571-mygj2nd4 2063 42 ) ) -RRB- cord-009571-mygj2nd4 2063 43 . . . cord-009571-mygj2nd4 2064 1 The the DT cord-009571-mygj2nd4 2064 2 target target NN cord-009571-mygj2nd4 2064 3 cells cell NNS cord-009571-mygj2nd4 2064 4 were be VBD cord-009571-mygj2nd4 2064 5 chicken chicken NN cord-009571-mygj2nd4 2064 6 erythrocytes erythrocyte NNS cord-009571-mygj2nd4 2064 7 coated coat VBN cord-009571-mygj2nd4 2064 8 with with IN cord-009571-mygj2nd4 2064 9 rabbit rabbit NN cord-009571-mygj2nd4 2064 10 anti anti JJ cord-009571-mygj2nd4 2064 11 - - JJ cord-009571-mygj2nd4 2064 12 chicken chicken JJ cord-009571-mygj2nd4 2064 13 erythrocyte erythrocyte NN cord-009571-mygj2nd4 2064 14 antibody antibody NN cord-009571-mygj2nd4 2064 15 ( ( -LRB- cord-009571-mygj2nd4 2064 16 IgG IgG NNP cord-009571-mygj2nd4 2064 17 fraction fraction NNP cord-009571-mygj2nd4 2064 18 ) ) -RRB- cord-009571-mygj2nd4 2064 19 ; ; : cord-009571-mygj2nd4 2064 20 multiple multiple JJ cord-009571-mygj2nd4 2064 21 effector effector NN cord-009571-mygj2nd4 2064 22 : : : cord-009571-mygj2nd4 2064 23 target target NN cord-009571-mygj2nd4 2064 24 ratios ratio NNS cord-009571-mygj2nd4 2064 25 were be VBD cord-009571-mygj2nd4 2064 26 studied study VBN cord-009571-mygj2nd4 2064 27 . . . cord-009571-mygj2nd4 2065 1 There there EX cord-009571-mygj2nd4 2065 2 was be VBD cord-009571-mygj2nd4 2065 3 no no DT cord-009571-mygj2nd4 2065 4 significant significant JJ cord-009571-mygj2nd4 2065 5 difference difference NN cord-009571-mygj2nd4 2065 6 in in IN cord-009571-mygj2nd4 2065 7 Lymphocytotoxic Lymphocytotoxic NNP cord-009571-mygj2nd4 2065 8 antibody antibody NN cord-009571-mygj2nd4 2065 9 is be VBZ cord-009571-mygj2nd4 2065 10 found find VBN cord-009571-mygj2nd4 2065 11 in in IN cord-009571-mygj2nd4 2065 12 the the DT cord-009571-mygj2nd4 2065 13 serum serum NN cord-009571-mygj2nd4 2065 14 of of IN cord-009571-mygj2nd4 2065 15 patients patient NNS cord-009571-mygj2nd4 2065 16 with with IN cord-009571-mygj2nd4 2065 17 systemic systemic JJ cord-009571-mygj2nd4 2065 18 lupus lupus NN cord-009571-mygj2nd4 2065 19 erythematosus erythematosus NN cord-009571-mygj2nd4 2065 20 ( ( -LRB- cord-009571-mygj2nd4 2065 21 SLE SLE NNP cord-009571-mygj2nd4 2065 22 ) ) -RRB- cord-009571-mygj2nd4 2065 23 . . . cord-009571-mygj2nd4 2066 1 The the DT cord-009571-mygj2nd4 2066 2 antibody antibody NN cord-009571-mygj2nd4 2066 3 is be VBZ cord-009571-mygj2nd4 2066 4 defined define VBN cord-009571-mygj2nd4 2066 5 by by IN cord-009571-mygj2nd4 2066 6 its -PRON- PRP$ cord-009571-mygj2nd4 2066 7 reaction reaction NN cord-009571-mygj2nd4 2066 8 with with IN cord-009571-mygj2nd4 2066 9 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 2066 10 , , , cord-009571-mygj2nd4 2066 11 but but CC cord-009571-mygj2nd4 2066 12 it -PRON- PRP cord-009571-mygj2nd4 2066 13 also also RB cord-009571-mygj2nd4 2066 14 reacts react VBZ cord-009571-mygj2nd4 2066 15 with with IN cord-009571-mygj2nd4 2066 16 antigens antigen NNS cord-009571-mygj2nd4 2066 17 on on IN cord-009571-mygj2nd4 2066 18 human human JJ cord-009571-mygj2nd4 2066 19 brain brain NN cord-009571-mygj2nd4 2066 20 tissue tissue NN cord-009571-mygj2nd4 2066 21 . . . cord-009571-mygj2nd4 2067 1 The the DT cord-009571-mygj2nd4 2067 2 existence existence NN cord-009571-mygj2nd4 2067 3 of of IN cord-009571-mygj2nd4 2067 4 an an DT cord-009571-mygj2nd4 2067 5 antibody antibody NN cord-009571-mygj2nd4 2067 6 in in IN cord-009571-mygj2nd4 2067 7 SLE SLE NNP cord-009571-mygj2nd4 2067 8 serum serum NN cord-009571-mygj2nd4 2067 9 recognizing recognize VBG cord-009571-mygj2nd4 2067 10 both both CC cord-009571-mygj2nd4 2067 11 brain brain NN cord-009571-mygj2nd4 2067 12 and and CC cord-009571-mygj2nd4 2067 13 lymphocyte lymphocyte NN cord-009571-mygj2nd4 2067 14 antigens antigen NNS cord-009571-mygj2nd4 2067 15 prompted prompt VBD cord-009571-mygj2nd4 2067 16 a a DT cord-009571-mygj2nd4 2067 17 search search NN cord-009571-mygj2nd4 2067 18 for for IN cord-009571-mygj2nd4 2067 19 a a DT cord-009571-mygj2nd4 2067 20 similar similar JJ cord-009571-mygj2nd4 2067 21 substance substance NN cord-009571-mygj2nd4 2067 22 in in IN cord-009571-mygj2nd4 2067 23 the the DT cord-009571-mygj2nd4 2067 24 cerebrospinal cerebrospinal JJ cord-009571-mygj2nd4 2067 25 fluid fluid NN cord-009571-mygj2nd4 2067 26 ( ( -LRB- cord-009571-mygj2nd4 2067 27 CSF CSF NNP cord-009571-mygj2nd4 2067 28 ) ) -RRB- cord-009571-mygj2nd4 2067 29 of of IN cord-009571-mygj2nd4 2067 30 SLE SLE NNP cord-009571-mygj2nd4 2067 31 patients patient NNS cord-009571-mygj2nd4 2067 32 , , , cord-009571-mygj2nd4 2067 33 with with IN cord-009571-mygj2nd4 2067 34 and and CC cord-009571-mygj2nd4 2067 35 without without IN cord-009571-mygj2nd4 2067 36 central central JJ cord-009571-mygj2nd4 2067 37 nervous nervous JJ cord-009571-mygj2nd4 2067 38 system system NN cord-009571-mygj2nd4 2067 39 ( ( -LRB- cord-009571-mygj2nd4 2067 40 CNS CNS NNP cord-009571-mygj2nd4 2067 41 ) ) -RRB- cord-009571-mygj2nd4 2067 42 disease disease NN cord-009571-mygj2nd4 2067 43 . . . cord-009571-mygj2nd4 2068 1 CSF CSF NNP cord-009571-mygj2nd4 2068 2 was be VBD cord-009571-mygj2nd4 2068 3 obtained obtain VBN cord-009571-mygj2nd4 2068 4 from from IN cord-009571-mygj2nd4 2068 5 17 17 CD cord-009571-mygj2nd4 2068 6 patients patient NNS cord-009571-mygj2nd4 2068 7 with with IN cord-009571-mygj2nd4 2068 8 SLE SLE NNP cord-009571-mygj2nd4 2068 9 in in IN cord-009571-mygj2nd4 2068 10 the the DT cord-009571-mygj2nd4 2068 11 course course NN cord-009571-mygj2nd4 2068 12 of of IN cord-009571-mygj2nd4 2068 13 evaluations evaluation NNS cord-009571-mygj2nd4 2068 14 for for IN cord-009571-mygj2nd4 2068 15 fever fever NN cord-009571-mygj2nd4 2068 16 , , , cord-009571-mygj2nd4 2068 17 headache headache NN cord-009571-mygj2nd4 2068 18 , , , cord-009571-mygj2nd4 2068 19 or or CC cord-009571-mygj2nd4 2068 20 manifestations manifestation NNS cord-009571-mygj2nd4 2068 21 of of IN cord-009571-mygj2nd4 2068 22 CNS CNS NNP cord-009571-mygj2nd4 2068 23 dysfunction dysfunction NN cord-009571-mygj2nd4 2068 24 . . . cord-009571-mygj2nd4 2069 1 An an DT cord-009571-mygj2nd4 2069 2 independent independent JJ cord-009571-mygj2nd4 2069 3 clinical clinical JJ cord-009571-mygj2nd4 2069 4 analysis analysis NN cord-009571-mygj2nd4 2069 5 of of IN cord-009571-mygj2nd4 2069 6 the the DT cord-009571-mygj2nd4 2069 7 SLE SLE NNP cord-009571-mygj2nd4 2069 8 patients patient NNS cord-009571-mygj2nd4 2069 9 and and CC cord-009571-mygj2nd4 2069 10 their -PRON- PRP$ cord-009571-mygj2nd4 2069 11 hospital hospital NN cord-009571-mygj2nd4 2069 12 records record NNS cord-009571-mygj2nd4 2069 13 revealed reveal VBD cord-009571-mygj2nd4 2069 14 that that IN cord-009571-mygj2nd4 2069 15 10 10 CD cord-009571-mygj2nd4 2069 16 of of IN cord-009571-mygj2nd4 2069 17 the the DT cord-009571-mygj2nd4 2069 18 17 17 CD cord-009571-mygj2nd4 2069 19 had have VBD cord-009571-mygj2nd4 2069 20 CNS CNS NNP cord-009571-mygj2nd4 2069 21 dysfunction dysfunction NN cord-009571-mygj2nd4 2069 22 attributable attributable JJ cord-009571-mygj2nd4 2069 23 to to IN cord-009571-mygj2nd4 2069 24 SLE SLE NNP cord-009571-mygj2nd4 2069 25 . . . cord-009571-mygj2nd4 2070 1 Criteria criterion NNS cord-009571-mygj2nd4 2070 2 for for IN cord-009571-mygj2nd4 2070 3 CNS CNS NNP cord-009571-mygj2nd4 2070 4 disease disease NN cord-009571-mygj2nd4 2070 5 were be VBD cord-009571-mygj2nd4 2070 6 one one CD cord-009571-mygj2nd4 2070 7 or or CC cord-009571-mygj2nd4 2070 8 more more JJR cord-009571-mygj2nd4 2070 9 of of IN cord-009571-mygj2nd4 2070 10 the the DT cord-009571-mygj2nd4 2070 11 following following NN cord-009571-mygj2nd4 2070 12 : : : cord-009571-mygj2nd4 2070 13 seizures seizure NNS cord-009571-mygj2nd4 2070 14 , , , cord-009571-mygj2nd4 2070 15 transverse transverse JJ cord-009571-mygj2nd4 2070 16 myelitis myelitis NNP cord-009571-mygj2nd4 2070 17 , , , cord-009571-mygj2nd4 2070 18 chorea chorea NN cord-009571-mygj2nd4 2070 19 , , , cord-009571-mygj2nd4 2070 20 ataxia ataxia NN cord-009571-mygj2nd4 2070 21 , , , cord-009571-mygj2nd4 2070 22 hemiparesis hemiparesis NNP cord-009571-mygj2nd4 2070 23 , , , cord-009571-mygj2nd4 2070 24 psychosis psychosis NN cord-009571-mygj2nd4 2070 25 , , , cord-009571-mygj2nd4 2070 26 or or CC cord-009571-mygj2nd4 2070 27 hallucinations hallucination NNS cord-009571-mygj2nd4 2070 28 . . . cord-009571-mygj2nd4 2071 1 Multiple multiple JJ cord-009571-mygj2nd4 2071 2 abnormalities abnormality NNS cord-009571-mygj2nd4 2071 3 were be VBD cord-009571-mygj2nd4 2071 4 present present JJ cord-009571-mygj2nd4 2071 5 in in IN cord-009571-mygj2nd4 2071 6 5 5 CD cord-009571-mygj2nd4 2071 7 of of IN cord-009571-mygj2nd4 2071 8 the the DT cord-009571-mygj2nd4 2071 9 10 10 CD cord-009571-mygj2nd4 2071 10 patients patient NNS cord-009571-mygj2nd4 2071 11 , , , cord-009571-mygj2nd4 2071 12 with with IN cord-009571-mygj2nd4 2071 13 l l NN cord-009571-mygj2nd4 2071 14 patient patient NN cord-009571-mygj2nd4 2071 15 having have VBG cord-009571-mygj2nd4 2071 16 3 3 CD cord-009571-mygj2nd4 2071 17 , , , cord-009571-mygj2nd4 2071 18 and and CC cord-009571-mygj2nd4 2071 19 4 4 CD cord-009571-mygj2nd4 2071 20 patients patient NNS cord-009571-mygj2nd4 2071 21 having have VBG cord-009571-mygj2nd4 2071 22 2 2 CD cord-009571-mygj2nd4 2071 23 of of IN cord-009571-mygj2nd4 2071 24 the the DT cord-009571-mygj2nd4 2071 25 above above JJ cord-009571-mygj2nd4 2071 26 abnormalities abnormality NNS cord-009571-mygj2nd4 2071 27 . . . cord-009571-mygj2nd4 2072 1 A a DT cord-009571-mygj2nd4 2072 2 population population NN cord-009571-mygj2nd4 2072 3 of of IN cord-009571-mygj2nd4 2072 4 patients patient NNS cord-009571-mygj2nd4 2072 5 without without IN cord-009571-mygj2nd4 2072 6 rheu rheu NN cord-009571-mygj2nd4 2072 7 - - HYPH cord-009571-mygj2nd4 2072 8 matic matic NN cord-009571-mygj2nd4 2072 9 disease disease NN cord-009571-mygj2nd4 2072 10 who who WP cord-009571-mygj2nd4 2072 11 were be VBD cord-009571-mygj2nd4 2072 12 being be VBG cord-009571-mygj2nd4 2072 13 evaluated evaluate VBN cord-009571-mygj2nd4 2072 14 for for IN cord-009571-mygj2nd4 2072 15 a a DT cord-009571-mygj2nd4 2072 16 variety variety NN cord-009571-mygj2nd4 2072 17 of of IN cord-009571-mygj2nd4 2072 18 neurological neurological JJ cord-009571-mygj2nd4 2072 19 abnormalities abnormality NNS cord-009571-mygj2nd4 2072 20 served serve VBD cord-009571-mygj2nd4 2072 21 a a DT cord-009571-mygj2nd4 2072 22 s s NNP cord-009571-mygj2nd4 2072 23 controls control NNS cord-009571-mygj2nd4 2072 24 . . . cord-009571-mygj2nd4 2073 1 The the DT cord-009571-mygj2nd4 2073 2 CSF CSF NNP cord-009571-mygj2nd4 2073 3 was be VBD cord-009571-mygj2nd4 2073 4 tested test VBN cord-009571-mygj2nd4 2073 5 in in IN cord-009571-mygj2nd4 2073 6 a a DT cord-009571-mygj2nd4 2073 7 dye dye NN cord-009571-mygj2nd4 2073 8 - - HYPH cord-009571-mygj2nd4 2073 9 exclusion exclusion NN cord-009571-mygj2nd4 2073 10 microcytotoxicity microcytotoxicity NN cord-009571-mygj2nd4 2073 11 assay assay NN cord-009571-mygj2nd4 2073 12 using use VBG cord-009571-mygj2nd4 2073 13 peripheral peripheral JJ cord-009571-mygj2nd4 2073 14 blood blood NN cord-009571-mygj2nd4 2073 15 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 2073 16 from from IN cord-009571-mygj2nd4 2073 17 3 3 CD cord-009571-mygj2nd4 2073 18 normal normal JJ cord-009571-mygj2nd4 2073 19 donors donor NNS cord-009571-mygj2nd4 2073 20 as as IN cord-009571-mygj2nd4 2073 21 targets target NNS cord-009571-mygj2nd4 2073 22 . . . cord-009571-mygj2nd4 2074 1 Cytotoxicity Cytotoxicity NNP cord-009571-mygj2nd4 2074 2 was be VBD cord-009571-mygj2nd4 2074 3 defined define VBN cord-009571-mygj2nd4 2074 4 as as IN cord-009571-mygj2nd4 2074 5 greater great JJR cord-009571-mygj2nd4 2074 6 than than IN cord-009571-mygj2nd4 2074 7 15 15 CD cord-009571-mygj2nd4 2074 8 % % NN cord-009571-mygj2nd4 2074 9 killing killing NN cord-009571-mygj2nd4 2074 10 of of IN cord-009571-mygj2nd4 2074 11 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 2074 12 from from IN cord-009571-mygj2nd4 2074 13 1 1 CD cord-009571-mygj2nd4 2074 14 or or CC cord-009571-mygj2nd4 2074 15 more more JJR cord-009571-mygj2nd4 2074 16 of of IN cord-009571-mygj2nd4 2074 17 the the DT cord-009571-mygj2nd4 2074 18 normal normal JJ cord-009571-mygj2nd4 2074 19 donors donor NNS cord-009571-mygj2nd4 2074 20 . . . cord-009571-mygj2nd4 2075 1 Nine nine CD cord-009571-mygj2nd4 2075 2 of of IN cord-009571-mygj2nd4 2075 3 the the DT cord-009571-mygj2nd4 2075 4 17 17 CD cord-009571-mygj2nd4 2075 5 SLE SLE NNP cord-009571-mygj2nd4 2075 6 patients'had patients'had NN cord-009571-mygj2nd4 2075 7 lymphocytotoxic lymphocytotoxic JJ cord-009571-mygj2nd4 2075 8 activity activity NN cord-009571-mygj2nd4 2075 9 in in IN cord-009571-mygj2nd4 2075 10 their -PRON- PRP$ cord-009571-mygj2nd4 2075 11 CSF csf NN cord-009571-mygj2nd4 2075 12 compared compare VBN cord-009571-mygj2nd4 2075 13 to to IN cord-009571-mygj2nd4 2075 14 1 1 CD cord-009571-mygj2nd4 2075 15 of of IN cord-009571-mygj2nd4 2075 16 31 31 CD cord-009571-mygj2nd4 2075 17 controls control NNS cord-009571-mygj2nd4 2075 18 . . . cord-009571-mygj2nd4 2076 1 When when WRB cord-009571-mygj2nd4 2076 2 lymphocytotoxicity lymphocytotoxicity NN cord-009571-mygj2nd4 2076 3 of of IN cord-009571-mygj2nd4 2076 4 CSF CSF NNP cord-009571-mygj2nd4 2076 5 was be VBD cord-009571-mygj2nd4 2076 6 compared compare VBN cord-009571-mygj2nd4 2076 7 with with IN cord-009571-mygj2nd4 2076 8 presence presence NN cord-009571-mygj2nd4 2076 9 or or CC cord-009571-mygj2nd4 2076 10 absence absence NN cord-009571-mygj2nd4 2076 11 of of IN cord-009571-mygj2nd4 2076 12 lupus lupus NN cord-009571-mygj2nd4 2076 13 CNS CNS NNP cord-009571-mygj2nd4 2076 14 disease disease NN cord-009571-mygj2nd4 2076 15 , , , cord-009571-mygj2nd4 2076 16 a a DT cord-009571-mygj2nd4 2076 17 positive positive JJ cord-009571-mygj2nd4 2076 18 correlation correlation NN cord-009571-mygj2nd4 2076 19 was be VBD cord-009571-mygj2nd4 2076 20 found find VBN cord-009571-mygj2nd4 2077 1 ( ( -LRB- cord-009571-mygj2nd4 2077 2 x x NNS cord-009571-mygj2nd4 2077 3 ' ' '' cord-009571-mygj2nd4 2077 4 = = SYM cord-009571-mygj2nd4 2077 5 3.82 3.82 CD cord-009571-mygj2nd4 2077 6 , , , cord-009571-mygj2nd4 2077 7 P p NN cord-009571-mygj2nd4 2077 8 < < XX cord-009571-mygj2nd4 2077 9 0.05 0.05 CD cord-009571-mygj2nd4 2077 10 ) ) -RRB- cord-009571-mygj2nd4 2077 11 . . . cord-009571-mygj2nd4 2078 1 The the DT cord-009571-mygj2nd4 2078 2 mean mean JJ cord-009571-mygj2nd4 2078 3 % % NN cord-009571-mygj2nd4 2078 4 lymphocytotoxicity lymphocytotoxicity NN cord-009571-mygj2nd4 2078 5 in in IN cord-009571-mygj2nd4 2078 6 the the DT cord-009571-mygj2nd4 2078 7 CNFs cnfs NN cord-009571-mygj2nd4 2078 8 did do VBD cord-009571-mygj2nd4 2078 9 not not RB cord-009571-mygj2nd4 2078 10 correlate correlate VB cord-009571-mygj2nd4 2078 11 with with IN cord-009571-mygj2nd4 2078 12 the the DT cord-009571-mygj2nd4 2078 13 serum serum NN cord-009571-mygj2nd4 2078 14 titer titer NN cord-009571-mygj2nd4 2078 15 of of IN cord-009571-mygj2nd4 2078 16 lymphocytotoxic lymphocytotoxic NNP cord-009571-mygj2nd4 2078 17 antibody antibody NNP cord-009571-mygj2nd4 2078 18 ( ( -LRB- cord-009571-mygj2nd4 2078 19 r r NN cord-009571-mygj2nd4 2078 20 = = NN cord-009571-mygj2nd4 2078 21 0.12 0.12 CD cord-009571-mygj2nd4 2078 22 ) ) -RRB- cord-009571-mygj2nd4 2078 23 . . . cord-009571-mygj2nd4 2079 1 Cytotoxic cytotoxic JJ cord-009571-mygj2nd4 2079 2 activity activity NN cord-009571-mygj2nd4 2079 3 to to IN cord-009571-mygj2nd4 2079 4 human human JJ cord-009571-mygj2nd4 2079 5 lymphocytes lymphocyte NNS cord-009571-mygj2nd4 2079 6 has have VBZ cord-009571-mygj2nd4 2079 7 been be VBN cord-009571-mygj2nd4 2079 8 identified identify VBN cord-009571-mygj2nd4 2079 9 in in IN cord-009571-mygj2nd4 2079 10 the the DT cord-009571-mygj2nd4 2079 11 CSF CSF NNP cord-009571-mygj2nd4 2079 12 of of IN cord-009571-mygj2nd4 2079 13 patients patient NNS cord-009571-mygj2nd4 2079 14 with with IN cord-009571-mygj2nd4 2079 15 CNS CNS NNP cord-009571-mygj2nd4 2079 16 manifestations manifestation NNS cord-009571-mygj2nd4 2079 17 of of IN cord-009571-mygj2nd4 2079 18 SLE SLE NNP cord-009571-mygj2nd4 2079 19 . . . cord-009571-mygj2nd4 2080 1 If if IN cord-009571-mygj2nd4 2080 2 the the DT cord-009571-mygj2nd4 2080 3 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 2080 4 is be VBZ cord-009571-mygj2nd4 2080 5 cross cross JJ cord-009571-mygj2nd4 2080 6 - - JJ cord-009571-mygj2nd4 2080 7 reactive reactive JJ cord-009571-mygj2nd4 2080 8 with with IN cord-009571-mygj2nd4 2080 9 neuronal neuronal JJ cord-009571-mygj2nd4 2080 10 antigens antigen NNS cord-009571-mygj2nd4 2080 11 , , , cord-009571-mygj2nd4 2080 12 as as IN cord-009571-mygj2nd4 2080 13 is be VBZ cord-009571-mygj2nd4 2080 14 the the DT cord-009571-mygj2nd4 2080 15 serum serum NN cord-009571-mygj2nd4 2080 16 antibody antibody NN cord-009571-mygj2nd4 2080 17 , , , cord-009571-mygj2nd4 2080 18 it -PRON- PRP cord-009571-mygj2nd4 2080 19 may may MD cord-009571-mygj2nd4 2080 20 have have VB cord-009571-mygj2nd4 2080 21 a a DT cord-009571-mygj2nd4 2080 22 pathogenetic pathogenetic JJ cord-009571-mygj2nd4 2080 23 role role NN cord-009571-mygj2nd4 2080 24 in in IN cord-009571-mygj2nd4 2080 25 CNS CNS NNP cord-009571-mygj2nd4 2080 26 lupus lupus NN cord-009571-mygj2nd4 2080 27 . . . cord-009571-mygj2nd4 2081 1 The the DT cord-009571-mygj2nd4 2081 2 role role NN cord-009571-mygj2nd4 2081 3 of of IN cord-009571-mygj2nd4 2081 4 bone bone NN cord-009571-mygj2nd4 2081 5 marrow marrow NN cord-009571-mygj2nd4 2081 6 derived derive VBN cord-009571-mygj2nd4 2081 7 cells cell NNS cord-009571-mygj2nd4 2081 8 in in IN cord-009571-mygj2nd4 2081 9 determining determine VBG cord-009571-mygj2nd4 2081 10 genetic genetic JJ cord-009571-mygj2nd4 2081 11 variation variation NN cord-009571-mygj2nd4 2081 12 in in IN cord-009571-mygj2nd4 2081 13 susceptibility susceptibility NN cord-009571-mygj2nd4 2081 14 to to TO cord-009571-mygj2nd4 2081 15 experimentally experimentally RB cord-009571-mygj2nd4 2081 16 induced induce VBN cord-009571-mygj2nd4 2081 17 amyloidosis amyloidosis NN cord-009571-mygj2nd4 2081 18 in in IN cord-009571-mygj2nd4 2081 19 mice mouse NNS cord-009571-mygj2nd4 2081 20 was be VBD cord-009571-mygj2nd4 2081 21 investigated investigate VBN cord-009571-mygj2nd4 2081 22 . . . cord-009571-mygj2nd4 2082 1 Mice mouse NNS cord-009571-mygj2nd4 2082 2 of of IN cord-009571-mygj2nd4 2082 3 the the DT cord-009571-mygj2nd4 2082 4 amyloid amyloid NN cord-009571-mygj2nd4 2082 5 susceptible susceptible JJ cord-009571-mygj2nd4 2082 6 CBA CBA NNP cord-009571-mygj2nd4 2082 7 strain strain NN cord-009571-mygj2nd4 2082 8 were be VBD cord-009571-mygj2nd4 2082 9 lethally lethally RB cord-009571-mygj2nd4 2082 10 irradiated irradiate VBN cord-009571-mygj2nd4 2082 11 and and CC cord-009571-mygj2nd4 2082 12 repopulated repopulate VBN cord-009571-mygj2nd4 2082 13 with with IN cord-009571-mygj2nd4 2082 14 marrow marrow NN cord-009571-mygj2nd4 2082 15 cells cell NNS cord-009571-mygj2nd4 2082 16 from from IN cord-009571-mygj2nd4 2082 17 the the DT cord-009571-mygj2nd4 2082 18 highly highly RB cord-009571-mygj2nd4 2082 19 resistant resistant JJ cord-009571-mygj2nd4 2082 20 A a DT cord-009571-mygj2nd4 2082 21 strain strain NN cord-009571-mygj2nd4 2082 22 . . . cord-009571-mygj2nd4 2083 1 Lethally lethally RB cord-009571-mygj2nd4 2083 2 irradiated irradiate VBN cord-009571-mygj2nd4 2083 3 CBA CBA NNP cord-009571-mygj2nd4 2083 4 mice mouse NNS cord-009571-mygj2nd4 2083 5 reconstituted reconstitute VBN cord-009571-mygj2nd4 2083 6 with with IN cord-009571-mygj2nd4 2083 7 syngeneic syngeneic NNS cord-009571-mygj2nd4 2083 8 marrow marrow NN cord-009571-mygj2nd4 2083 9 served serve VBD cord-009571-mygj2nd4 2083 10 as as IN cord-009571-mygj2nd4 2083 11 controls control NNS cord-009571-mygj2nd4 2083 12 . . . cord-009571-mygj2nd4 2084 1 To to TO cord-009571-mygj2nd4 2084 2 determine determine VB cord-009571-mygj2nd4 2084 3 the the DT cord-009571-mygj2nd4 2084 4 effects effect NNS cord-009571-mygj2nd4 2084 5 of of IN cord-009571-mygj2nd4 2084 6 irradiation irradiation NN cord-009571-mygj2nd4 2084 7 per per FW cord-009571-mygj2nd4 2084 8 se se FW cord-009571-mygj2nd4 2084 9 on on IN cord-009571-mygj2nd4 2084 10 amyloid amyloid NN cord-009571-mygj2nd4 2084 11 production production NN cord-009571-mygj2nd4 2084 12 , , , cord-009571-mygj2nd4 2084 13 normal normal JJ cord-009571-mygj2nd4 2084 14 CBA CBA NNP cord-009571-mygj2nd4 2084 15 mice mouse NNS cord-009571-mygj2nd4 2084 16 , , , cord-009571-mygj2nd4 2084 17 as as RB cord-009571-mygj2nd4 2084 18 well well RB cord-009571-mygj2nd4 2084 19 as as IN cord-009571-mygj2nd4 2084 20 A a DT cord-009571-mygj2nd4 2084 21 strain strain NN cord-009571-mygj2nd4 2084 22 mice mouse NNS cord-009571-mygj2nd4 2084 23 that that WDT cord-009571-mygj2nd4 2084 24 were be VBD cord-009571-mygj2nd4 2084 25 irradiated irradiate VBN cord-009571-mygj2nd4 2084 26 and and CC cord-009571-mygj2nd4 2084 27 reconstituted reconstitute VBN cord-009571-mygj2nd4 2084 28 with with IN cord-009571-mygj2nd4 2084 29 A a DT cord-009571-mygj2nd4 2084 30 marrow marrow NN cord-009571-mygj2nd4 2084 31 , , , cord-009571-mygj2nd4 2084 32 were be VBD cord-009571-mygj2nd4 2084 33 also also RB cord-009571-mygj2nd4 2084 34 studied study VBN cord-009571-mygj2nd4 2084 35 . . . cord-009571-mygj2nd4 2085 1 Following follow VBG cord-009571-mygj2nd4 2085 2 4 4 CD cord-009571-mygj2nd4 2085 3 weeks week NNS cord-009571-mygj2nd4 2085 4 of of IN cord-009571-mygj2nd4 2085 5 daily daily JJ cord-009571-mygj2nd4 2085 6 subcutaneous subcutaneous JJ cord-009571-mygj2nd4 2085 7 casein casein NN cord-009571-mygj2nd4 2085 8 injections injection NNS cord-009571-mygj2nd4 2085 9 , , , cord-009571-mygj2nd4 2085 10 spleen spleen NN cord-009571-mygj2nd4 2085 11 sections section NNS cord-009571-mygj2nd4 2085 12 stained stain VBN cord-009571-mygj2nd4 2085 13 with with IN cord-009571-mygj2nd4 2085 14 Congo Congo NNP cord-009571-mygj2nd4 2085 15 red red NN cord-009571-mygj2nd4 2085 16 were be VBD cord-009571-mygj2nd4 2085 17 scored score VBN cord-009571-mygj2nd4 2085 18 for for IN cord-009571-mygj2nd4 2085 19 the the DT cord-009571-mygj2nd4 2085 20 degree degree NN cord-009571-mygj2nd4 2085 21 of of IN cord-009571-mygj2nd4 2085 22 amyloidosis amyloidosis NN cord-009571-mygj2nd4 2085 23 by by IN cord-009571-mygj2nd4 2085 24 independent independent JJ cord-009571-mygj2nd4 2085 25 blind blind JJ cord-009571-mygj2nd4 2085 26 observers observer NNS cord-009571-mygj2nd4 2085 27 using use VBG cord-009571-mygj2nd4 2085 28 the the DT cord-009571-mygj2nd4 2085 29 following following JJ cord-009571-mygj2nd4 2085 30 4 4 CD cord-009571-mygj2nd4 2085 31 point point NN cord-009571-mygj2nd4 2085 32 scale scale NN cord-009571-mygj2nd4 2085 33 : : : cord-009571-mygj2nd4 2085 34 grade grade NN cord-009571-mygj2nd4 2085 35 I I NNP cord-009571-mygj2nd4 2085 36 - - : cord-009571-mygj2nd4 2085 37 a a DT cord-009571-mygj2nd4 2085 38 rim rim NN cord-009571-mygj2nd4 2085 39 of of IN cord-009571-mygj2nd4 2085 40 amyloid amyloid NN cord-009571-mygj2nd4 2085 41 around around RB cord-009571-mygj2nd4 2085 42 1 1 CD cord-009571-mygj2nd4 2085 43 or or CC cord-009571-mygj2nd4 2085 44 more more JJR cord-009571-mygj2nd4 2085 45 splenic splenic JJ cord-009571-mygj2nd4 2085 46 follicles follicle NNS cord-009571-mygj2nd4 2085 47 ; ; : cord-009571-mygj2nd4 2085 48 grade grade NN cord-009571-mygj2nd4 2085 49 2-a 2-a CD cord-009571-mygj2nd4 2085 50 rim rim NN cord-009571-mygj2nd4 2085 51 of of IN cord-009571-mygj2nd4 2085 52 amyloid amyloid NN cord-009571-mygj2nd4 2085 53 in in IN cord-009571-mygj2nd4 2085 54 more more JJR cord-009571-mygj2nd4 2085 55 than than IN cord-009571-mygj2nd4 2085 56 50 50 CD cord-009571-mygj2nd4 2085 57 % % NN cord-009571-mygj2nd4 2085 58 of of IN cord-009571-mygj2nd4 2085 59 splenic splenic JJ cord-009571-mygj2nd4 2085 60 follicles follicle NNS cord-009571-mygj2nd4 2085 61 ; ; : cord-009571-mygj2nd4 2085 62 grade grade NN cord-009571-mygj2nd4 2085 63 3-a 3-a CD cord-009571-mygj2nd4 2085 64 rim rim NN cord-009571-mygj2nd4 2085 65 of of IN cord-009571-mygj2nd4 2085 66 amyloid amyloid NN cord-009571-mygj2nd4 2085 67 in in IN cord-009571-mygj2nd4 2085 68 all all DT cord-009571-mygj2nd4 2085 69 splenic splenic JJ cord-009571-mygj2nd4 2085 70 follicles follicle NNS cord-009571-mygj2nd4 2085 71 ; ; : cord-009571-mygj2nd4 2085 72 grade grade NN cord-009571-mygj2nd4 2085 73 4-diffuse 4-diffuse CD cord-009571-mygj2nd4 2085 74 splenic splenic JJ cord-009571-mygj2nd4 2085 75 amyloid amyloid NN cord-009571-mygj2nd4 2085 76 with with IN cord-009571-mygj2nd4 2085 77 bridging bridge VBG cord-009571-mygj2nd4 2085 78 be be VB cord-009571-mygj2nd4 2085 79 - - HYPH cord-009571-mygj2nd4 2085 80 tween tween NN cord-009571-mygj2nd4 2085 81 almost almost RB cord-009571-mygj2nd4 2085 82 all all DT cord-009571-mygj2nd4 2085 83 follicles follicle NNS cord-009571-mygj2nd4 2085 84 and and CC cord-009571-mygj2nd4 2085 85 some some DT cord-009571-mygj2nd4 2085 86 distortion distortion NN cord-009571-mygj2nd4 2085 87 of of IN cord-009571-mygj2nd4 2085 88 the the DT cord-009571-mygj2nd4 2085 89 splenic splenic JJ cord-009571-mygj2nd4 2085 90 architecture architecture NN cord-009571-mygj2nd4 2085 91 . . . cord-009571-mygj2nd4 2086 1 Thirty thirty CD cord-009571-mygj2nd4 2086 2 percent percent NN cord-009571-mygj2nd4 2086 3 of of IN cord-009571-mygj2nd4 2086 4 CBA CBA NNP cord-009571-mygj2nd4 2086 5 mice mouse NNS cord-009571-mygj2nd4 2086 6 given give VBN cord-009571-mygj2nd4 2086 7 A a DT cord-009571-mygj2nd4 2086 8 marrow marrow NN cord-009571-mygj2nd4 2086 9 failed fail VBD cord-009571-mygj2nd4 2086 10 to to TO cord-009571-mygj2nd4 2086 11 develop develop VB cord-009571-mygj2nd4 2086 12 amyloid amyloid NN cord-009571-mygj2nd4 2086 13 , , , cord-009571-mygj2nd4 2086 14 with with IN cord-009571-mygj2nd4 2086 15 an an DT cord-009571-mygj2nd4 2086 16 average average JJ cord-009571-mygj2nd4 2086 17 score score NN cord-009571-mygj2nd4 2086 18 of of IN cord-009571-mygj2nd4 2086 19 1.1 1.1 CD cord-009571-mygj2nd4 2086 20 for for IN cord-009571-mygj2nd4 2086 21 this this DT cord-009571-mygj2nd4 2086 22 entire entire JJ cord-009571-mygj2nd4 2086 23 group group NN cord-009571-mygj2nd4 2086 24 . . . cord-009571-mygj2nd4 2087 1 In in IN cord-009571-mygj2nd4 2087 2 contrast contrast NN cord-009571-mygj2nd4 2087 3 , , , cord-009571-mygj2nd4 2087 4 control control NN cord-009571-mygj2nd4 2087 5 mice mouse NNS cord-009571-mygj2nd4 2087 6 given give VBN cord-009571-mygj2nd4 2087 7 syngeneic syngeneic NNS cord-009571-mygj2nd4 2087 8 marrow marrow NN cord-009571-mygj2nd4 2087 9 all all DT cord-009571-mygj2nd4 2087 10 developed develop VBD cord-009571-mygj2nd4 2087 11 significantly significantly RB cord-009571-mygj2nd4 2087 12 more more RBR cord-009571-mygj2nd4 2087 13 amyloid amyloid NN cord-009571-mygj2nd4 2087 14 , , , cord-009571-mygj2nd4 2087 15 with with IN cord-009571-mygj2nd4 2087 16 an an DT cord-009571-mygj2nd4 2087 17 average average JJ cord-009571-mygj2nd4 2087 18 score score NN cord-009571-mygj2nd4 2087 19 of of IN cord-009571-mygj2nd4 2087 20 3.4 3.4 CD cord-009571-mygj2nd4 2087 21 . . . cord-009571-mygj2nd4 2088 1 Non Non NNS cord-009571-mygj2nd4 2088 2 - - JJ cord-009571-mygj2nd4 2088 3 irradiated irradiated JJ cord-009571-mygj2nd4 2088 4 CBA CBA NNP cord-009571-mygj2nd4 2088 5 mice mouse NNS cord-009571-mygj2nd4 2088 6 developed develop VBD cord-009571-mygj2nd4 2088 7 a a DT cord-009571-mygj2nd4 2088 8 n n NN cord-009571-mygj2nd4 2088 9 intermediate intermediate JJ cord-009571-mygj2nd4 2088 10 severity severity NN cord-009571-mygj2nd4 2088 11 of of IN cord-009571-mygj2nd4 2088 12 lesions lesion NNS cord-009571-mygj2nd4 2088 13 . . . cord-009571-mygj2nd4 2089 1 Irradiated irradiate VBN cord-009571-mygj2nd4 2089 2 A a DT cord-009571-mygj2nd4 2089 3 mice mouse NNS cord-009571-mygj2nd4 2089 4 remained remain VBD cord-009571-mygj2nd4 2089 5 amyloid amyloid NN cord-009571-mygj2nd4 2089 6 free free JJ cord-009571-mygj2nd4 2089 7 . . . cord-009571-mygj2nd4 2090 1 The the DT cord-009571-mygj2nd4 2090 2 progression progression NN cord-009571-mygj2nd4 2090 3 of of IN cord-009571-mygj2nd4 2090 4 amyloidosis amyloidosis NN cord-009571-mygj2nd4 2090 5 in in IN cord-009571-mygj2nd4 2090 6 CBA CBA NNP cord-009571-mygj2nd4 2090 7 mice mouse NNS cord-009571-mygj2nd4 2090 8 was be VBD cord-009571-mygj2nd4 2090 9 significantly significantly RB cord-009571-mygj2nd4 2090 10 retarded retard VBN cord-009571-mygj2nd4 2090 11 by by IN cord-009571-mygj2nd4 2090 12 grafting grafting NN cord-009571-mygj2nd4 2090 13 of of IN cord-009571-mygj2nd4 2090 14 marrow marrow NN cord-009571-mygj2nd4 2090 15 from from IN cord-009571-mygj2nd4 2090 16 the the DT cord-009571-mygj2nd4 2090 17 resistant resistant JJ cord-009571-mygj2nd4 2090 18 A a DT cord-009571-mygj2nd4 2090 19 strain strain NN cord-009571-mygj2nd4 2090 20 , , , cord-009571-mygj2nd4 2090 21 even even RB cord-009571-mygj2nd4 2090 22 though though IN cord-009571-mygj2nd4 2090 23 irradiation irradiation NN cord-009571-mygj2nd4 2090 24 seemed seem VBD cord-009571-mygj2nd4 2090 25 to to TO cord-009571-mygj2nd4 2090 26 accelerate accelerate VB cord-009571-mygj2nd4 2090 27 amyloid amyloid NN cord-009571-mygj2nd4 2090 28 production production NN cord-009571-mygj2nd4 2090 29 in in IN cord-009571-mygj2nd4 2090 30 CBA CBA NNP cord-009571-mygj2nd4 2090 31 mice mouse NNS cord-009571-mygj2nd4 2090 32 . . . cord-009571-mygj2nd4 2091 1 The the DT cord-009571-mygj2nd4 2091 2 resistance resistance NN cord-009571-mygj2nd4 2091 3 of of IN cord-009571-mygj2nd4 2091 4 the the DT cord-009571-mygj2nd4 2091 5 A a DT cord-009571-mygj2nd4 2091 6 strain strain NN cord-009571-mygj2nd4 2091 7 to to IN cord-009571-mygj2nd4 2091 8 amyloidosis amyloidosis NN cord-009571-mygj2nd4 2091 9 was be VBD cord-009571-mygj2nd4 2091 10 not not RB cord-009571-mygj2nd4 2091 11 affected affect VBN cord-009571-mygj2nd4 2091 12 by by IN cord-009571-mygj2nd4 2091 13 lethal lethal JJ cord-009571-mygj2nd4 2091 14 irradiation irradiation NN cord-009571-mygj2nd4 2091 15 . . . cord-009571-mygj2nd4 2092 1 These these DT cord-009571-mygj2nd4 2092 2 data datum NNS cord-009571-mygj2nd4 2092 3 demonstrate demonstrate VBP cord-009571-mygj2nd4 2092 4 that that IN cord-009571-mygj2nd4 2092 5 bone bone NN cord-009571-mygj2nd4 2092 6 marrow marrow NN cord-009571-mygj2nd4 2092 7 derived derive VBN cord-009571-mygj2nd4 2092 8 cells cell NNS cord-009571-mygj2nd4 2092 9 are be VBP cord-009571-mygj2nd4 2092 10 an an DT cord-009571-mygj2nd4 2092 11 important important JJ cord-009571-mygj2nd4 2092 12 factor factor NN cord-009571-mygj2nd4 2092 13 in in IN cord-009571-mygj2nd4 2092 14 the the DT cord-009571-mygj2nd4 2092 15 pathogenesis pathogenesis NN cord-009571-mygj2nd4 2092 16 of of IN cord-009571-mygj2nd4 2092 17 amyloidosis amyloidosis NN cord-009571-mygj2nd4 2092 18 and and CC cord-009571-mygj2nd4 2092 19 that that IN cord-009571-mygj2nd4 2092 20 the the DT cord-009571-mygj2nd4 2092 21 genetic genetic JJ cord-009571-mygj2nd4 2092 22 difference difference NN cord-009571-mygj2nd4 2092 23 between between IN cord-009571-mygj2nd4 2092 24 susceptible susceptible JJ cord-009571-mygj2nd4 2092 25 and and CC cord-009571-mygj2nd4 2092 26 resistant resistant JJ cord-009571-mygj2nd4 2092 27 mouse mouse NN cord-009571-mygj2nd4 2092 28 strains strain NNS cord-009571-mygj2nd4 2092 29 lies lie VBZ cord-009571-mygj2nd4 2092 30 , , , cord-009571-mygj2nd4 2092 31 at at IN cord-009571-mygj2nd4 2092 32 least least JJS cord-009571-mygj2nd4 2092 33 partially partially RB cord-009571-mygj2nd4 2092 34 , , , cord-009571-mygj2nd4 2092 35 in in IN cord-009571-mygj2nd4 2092 36 their -PRON- PRP$ cord-009571-mygj2nd4 2092 37 hematopoietic hematopoietic JJ cord-009571-mygj2nd4 2092 38 tissues tissue NNS cord-009571-mygj2nd4 2092 39 . . . cord-009571-mygj2nd4 2093 1 The the DT cord-009571-mygj2nd4 2093 2 biochemical biochemical JJ cord-009571-mygj2nd4 2093 3 features feature NNS cord-009571-mygj2nd4 2093 4 of of IN cord-009571-mygj2nd4 2093 5 2 2 CD cord-009571-mygj2nd4 2093 6 families family NNS cord-009571-mygj2nd4 2093 7 with with IN cord-009571-mygj2nd4 2093 8 purine purine NN cord-009571-mygj2nd4 2093 9 nucleoside nucleoside NN cord-009571-mygj2nd4 2093 10 phosphorylase phosphorylase NNP cord-009571-mygj2nd4 2093 11 ( ( -LRB- cord-009571-mygj2nd4 2093 12 PNP PNP NNP cord-009571-mygj2nd4 2093 13 ) ) -RRB- cord-009571-mygj2nd4 2093 14 deficiency deficiency NN cord-009571-mygj2nd4 2093 15 and and CC cord-009571-mygj2nd4 2093 16 T t NN cord-009571-mygj2nd4 2093 17 - - HYPH cord-009571-mygj2nd4 2093 18 cell cell NN cord-009571-mygj2nd4 2093 19 immunodeficiency immunodeficiency NN cord-009571-mygj2nd4 2093 20 disease disease NN cord-009571-mygj2nd4 2093 21 were be VBD cord-009571-mygj2nd4 2093 22 compared compare VBN cord-009571-mygj2nd4 2093 23 . . . cord-009571-mygj2nd4 2094 1 The the DT cord-009571-mygj2nd4 2094 2 erythrocyte erythrocyte NN cord-009571-mygj2nd4 2094 3 enzyme enzyme NN cord-009571-mygj2nd4 2094 4 from from IN cord-009571-mygj2nd4 2094 5 2 2 CD cord-009571-mygj2nd4 2094 6 brothers brother NNS cord-009571-mygj2nd4 2094 7 in in IN cord-009571-mygj2nd4 2094 8 family family NN cord-009571-mygj2nd4 2094 9 1 1 CD cord-009571-mygj2nd4 2094 10 had have VBD cord-009571-mygj2nd4 2094 11 0.45 0.45 CD cord-009571-mygj2nd4 2094 12 % % NN cord-009571-mygj2nd4 2094 13 normal normal JJ cord-009571-mygj2nd4 2094 14 PNP PNP NNP cord-009571-mygj2nd4 2094 15 activity activity NN cord-009571-mygj2nd4 2094 16 . . . cord-009571-mygj2nd4 2095 1 Plasma plasma NN cord-009571-mygj2nd4 2095 2 urate urate NN cord-009571-mygj2nd4 2095 3 values value NNS cord-009571-mygj2nd4 2095 4 in in IN cord-009571-mygj2nd4 2095 5 these these DT cord-009571-mygj2nd4 2095 6 patients patient NNS cord-009571-mygj2nd4 2095 7 are be VBP cord-009571-mygj2nd4 2095 8 2.6 2.6 CD cord-009571-mygj2nd4 2095 9 mg mg NNP cord-009571-mygj2nd4 2095 10 / / SYM cord-009571-mygj2nd4 2095 11 dl dl NN cord-009571-mygj2nd4 2095 12 and and CC cord-009571-mygj2nd4 2095 13 plasma plasma NN cord-009571-mygj2nd4 2095 14 inosine inosine JJ cord-009571-mygj2nd4 2095 15 levels level NNS cord-009571-mygj2nd4 2095 16 are be VBP cord-009571-mygj2nd4 2095 17 41.2 41.2 CD cord-009571-mygj2nd4 2095 18 and and CC cord-009571-mygj2nd4 2095 19 45.2 45.2 CD cord-009571-mygj2nd4 2096 1 p p NNP cord-009571-mygj2nd4 2096 2 M M NNP cord-009571-mygj2nd4 2096 3 . . . cord-009571-mygj2nd4 2097 1 Urine urine NN cord-009571-mygj2nd4 2097 2 samples sample NNS cord-009571-mygj2nd4 2097 3 contain contain VBP cord-009571-mygj2nd4 2097 4 uric uric NN cord-009571-mygj2nd4 2097 5 acid acid NN cord-009571-mygj2nd4 2097 6 454 454 CD cord-009571-mygj2nd4 2097 7 and and CC cord-009571-mygj2nd4 2097 8 527 527 CD cord-009571-mygj2nd4 2097 9 mg mg NNP cord-009571-mygj2nd4 2097 10 / / SYM cord-009571-mygj2nd4 2097 11 gm gm NNP cord-009571-mygj2nd4 2097 12 creatinine creatinine NN cord-009571-mygj2nd4 2097 13 , , , cord-009571-mygj2nd4 2097 14 inosine inosine NNP cord-009571-mygj2nd4 2097 15 5.1 5.1 CD cord-009571-mygj2nd4 2097 16 and and CC cord-009571-mygj2nd4 2097 17 4.7 4.7 CD cord-009571-mygj2nd4 2097 18 millimoles millimole NNS cord-009571-mygj2nd4 2097 19 / / SYM cord-009571-mygj2nd4 2097 20 gm gm NNP cord-009571-mygj2nd4 2097 21 creatinine creatinine NN cord-009571-mygj2nd4 2097 22 , , , cord-009571-mygj2nd4 2097 23 and and CC cord-009571-mygj2nd4 2097 24 guanosine guanosine NNP cord-009571-mygj2nd4 2097 25 1.4 1.4 CD cord-009571-mygj2nd4 2097 26 and and CC cord-009571-mygj2nd4 2097 27 1.8 1.8 CD cord-009571-mygj2nd4 2097 28 milli milli NNS cord-009571-mygj2nd4 2097 29 - - HYPH cord-009571-mygj2nd4 2097 30 moles mole NNS cord-009571-mygj2nd4 2097 31 / / SYM cord-009571-mygj2nd4 2097 32 gm gm NNP cord-009571-mygj2nd4 2097 33 creatinine creatinine NN cord-009571-mygj2nd4 2097 34 . . . cord-009571-mygj2nd4 2098 1 When when WRB cord-009571-mygj2nd4 2098 2 compared compare VBN cord-009571-mygj2nd4 2098 3 t t NN cord-009571-mygj2nd4 2098 4 o o NN cord-009571-mygj2nd4 2098 5 normal normal JJ cord-009571-mygj2nd4 2098 6 , , , cord-009571-mygj2nd4 2098 7 their -PRON- PRP$ cord-009571-mygj2nd4 2098 8 enzymes enzyme NNS cord-009571-mygj2nd4 2098 9 showed show VBD cord-009571-mygj2nd4 2098 10 a a DT cord-009571-mygj2nd4 2098 11 ) ) -RRB- cord-009571-mygj2nd4 2098 12 a a DT cord-009571-mygj2nd4 2098 13 10-fold 10-fold JJ cord-009571-mygj2nd4 2098 14 increase increase NN cord-009571-mygj2nd4 2098 15 in in IN cord-009571-mygj2nd4 2098 16 the the DT cord-009571-mygj2nd4 2098 17 apparent apparent JJ cord-009571-mygj2nd4 2098 18 Km km NN cord-009571-mygj2nd4 2098 19 for for IN cord-009571-mygj2nd4 2098 20 inosine inosine NN cord-009571-mygj2nd4 2098 21 , , , cord-009571-mygj2nd4 2098 22 b b LS cord-009571-mygj2nd4 2098 23 ) ) -RRB- cord-009571-mygj2nd4 2098 24 a a DT cord-009571-mygj2nd4 2098 25 diminution diminution NN cord-009571-mygj2nd4 2098 26 of of IN cord-009571-mygj2nd4 2098 27 the the DT cord-009571-mygj2nd4 2098 28 isoelectric isoelectric JJ cord-009571-mygj2nd4 2098 29 p p NN cord-009571-mygj2nd4 2098 30 H h NN cord-009571-mygj2nd4 2098 31 from from IN cord-009571-mygj2nd4 2098 32 normal normal JJ cord-009571-mygj2nd4 2098 33 values value NNS cord-009571-mygj2nd4 2098 34 of of IN cord-009571-mygj2nd4 2098 35 5.4 5.4 CD cord-009571-mygj2nd4 2098 36 to to TO cord-009571-mygj2nd4 2098 37 5.8 5.8 CD cord-009571-mygj2nd4 2098 38 to to IN cord-009571-mygj2nd4 2098 39 5.08 5.08 CD cord-009571-mygj2nd4 2098 40 to to IN cord-009571-mygj2nd4 2098 41 5.26 5.26 CD cord-009571-mygj2nd4 2098 42 , , , cord-009571-mygj2nd4 2098 43 c c NN cord-009571-mygj2nd4 2098 44 ) ) -RRB- cord-009571-mygj2nd4 2099 1 an an DT cord-009571-mygj2nd4 2099 2 inability inability NN cord-009571-mygj2nd4 2099 3 of of IN cord-009571-mygj2nd4 2099 4 inosine inosine NNP cord-009571-mygj2nd4 2099 5 to to TO cord-009571-mygj2nd4 2099 6 protect protect VB cord-009571-mygj2nd4 2099 7 the the DT cord-009571-mygj2nd4 2099 8 mutant mutant JJ cord-009571-mygj2nd4 2099 9 enzyme enzyme NN cord-009571-mygj2nd4 2099 10 against against IN cord-009571-mygj2nd4 2099 11 thermal thermal JJ cord-009571-mygj2nd4 2099 12 inactivation inactivation NN cord-009571-mygj2nd4 2099 13 as as IN cord-009571-mygj2nd4 2099 14 compared compare VBN cord-009571-mygj2nd4 2099 15 to to IN cord-009571-mygj2nd4 2099 16 the the DT cord-009571-mygj2nd4 2099 17 protection protection NN cord-009571-mygj2nd4 2099 18 of of IN cord-009571-mygj2nd4 2099 19 the the DT cord-009571-mygj2nd4 2099 20 normal normal JJ cord-009571-mygj2nd4 2099 21 enzyme enzyme NN cord-009571-mygj2nd4 2099 22 , , , cord-009571-mygj2nd4 2099 23 d d NN cord-009571-mygj2nd4 2099 24 ) ) -RRB- cord-009571-mygj2nd4 2100 1 a a DT cord-009571-mygj2nd4 2100 2 loss loss NN cord-009571-mygj2nd4 2100 3 of of IN cord-009571-mygj2nd4 2100 4 the the DT cord-009571-mygj2nd4 2100 5 normal normal JJ cord-009571-mygj2nd4 2100 6 near near IN cord-009571-mygj2nd4 2100 7 optimum optimum JJ cord-009571-mygj2nd4 2100 8 activity activity NN cord-009571-mygj2nd4 2100 9 a a DT cord-009571-mygj2nd4 2100 10 t t NN cord-009571-mygj2nd4 2100 11 pH pH NNP cord-009571-mygj2nd4 2100 12 7.4 7.4 CD cord-009571-mygj2nd4 2100 13 , , , cord-009571-mygj2nd4 2100 14 and and CC cord-009571-mygj2nd4 2100 15 3 3 LS cord-009571-mygj2nd4 2100 16 ) ) -RRB- cord-009571-mygj2nd4 2100 17 a a DT cord-009571-mygj2nd4 2100 18 normal normal JJ cord-009571-mygj2nd4 2100 19 value value NN cord-009571-mygj2nd4 2100 20 for for IN cord-009571-mygj2nd4 2100 21 the the DT cord-009571-mygj2nd4 2100 22 stokes stokes NNP cord-009571-mygj2nd4 2100 23 radius radius NN cord-009571-mygj2nd4 2100 24 . . . cord-009571-mygj2nd4 2101 1 The the DT cord-009571-mygj2nd4 2101 2 enzyme enzyme NN cord-009571-mygj2nd4 2101 3 from from IN cord-009571-mygj2nd4 2101 4 a a DT cord-009571-mygj2nd4 2101 5 patient patient NN cord-009571-mygj2nd4 2101 6 in in IN cord-009571-mygj2nd4 2101 7 family family NN cord-009571-mygj2nd4 2101 8 2 2 CD cord-009571-mygj2nd4 2101 9 has have VBZ cord-009571-mygj2nd4 2101 10 0.07 0.07 CD cord-009571-mygj2nd4 2101 11 % % NN cord-009571-mygj2nd4 2101 12 of of IN cord-009571-mygj2nd4 2101 13 normal normal JJ cord-009571-mygj2nd4 2101 14 activity activity NN cord-009571-mygj2nd4 2101 15 . . . cord-009571-mygj2nd4 2102 1 This this DT cord-009571-mygj2nd4 2102 2 patient patient NN cord-009571-mygj2nd4 2102 3 has have VBZ cord-009571-mygj2nd4 2102 4 a a DT cord-009571-mygj2nd4 2102 5 plasma plasma NN cord-009571-mygj2nd4 2102 6 urate urate NN cord-009571-mygj2nd4 2102 7 of of IN cord-009571-mygj2nd4 2102 8 1.8 1.8 CD cord-009571-mygj2nd4 2102 9 mg mg NNP cord-009571-mygj2nd4 2102 10 / / SYM cord-009571-mygj2nd4 2102 11 dl dl NNP cord-009571-mygj2nd4 2102 12 and and CC cord-009571-mygj2nd4 2102 13 a a DT cord-009571-mygj2nd4 2102 14 plasma plasma NN cord-009571-mygj2nd4 2102 15 inosine inosine NN cord-009571-mygj2nd4 2102 16 of of IN cord-009571-mygj2nd4 2102 17 38 38 CD cord-009571-mygj2nd4 2102 18 w w NN cord-009571-mygj2nd4 2102 19 M M NNP cord-009571-mygj2nd4 2102 20 . . . cord-009571-mygj2nd4 2103 1 Urine urine NN cord-009571-mygj2nd4 2103 2 samples sample NNS cord-009571-mygj2nd4 2103 3 contain contain VBP cord-009571-mygj2nd4 2103 4 uric uric NN cord-009571-mygj2nd4 2103 5 acid acid NN cord-009571-mygj2nd4 2103 6 73 73 CD cord-009571-mygj2nd4 2103 7 mg mg NNP cord-009571-mygj2nd4 2103 8 / / SYM cord-009571-mygj2nd4 2103 9 gm gm NNP cord-009571-mygj2nd4 2103 10 creatinine creatinine NN cord-009571-mygj2nd4 2103 11 , , , cord-009571-mygj2nd4 2103 12 inosine inosine NNP cord-009571-mygj2nd4 2103 13 14.8 14.8 CD cord-009571-mygj2nd4 2103 14 millimoles millimoles NNP cord-009571-mygj2nd4 2103 15 / / SYM cord-009571-mygj2nd4 2103 16 gm gm NNP cord-009571-mygj2nd4 2103 17 creati creati NNP cord-009571-mygj2nd4 2103 18 - - HYPH cord-009571-mygj2nd4 2103 19 nine nine CD cord-009571-mygj2nd4 2103 20 , , , cord-009571-mygj2nd4 2103 21 and and CC cord-009571-mygj2nd4 2103 22 guanosine guanosine NN cord-009571-mygj2nd4 2103 23 4.8 4.8 CD cord-009571-mygj2nd4 2103 24 millimoles millimole NNS cord-009571-mygj2nd4 2103 25 / / SYM cord-009571-mygj2nd4 2103 26 gm gm NNP cord-009571-mygj2nd4 2103 27 creatinine creatinine NN cord-009571-mygj2nd4 2103 28 . . . cord-009571-mygj2nd4 2104 1 The the DT cord-009571-mygj2nd4 2104 2 enzyme enzyme NN cord-009571-mygj2nd4 2104 3 protein protein NN cord-009571-mygj2nd4 2104 4 had have VBD cord-009571-mygj2nd4 2104 5 a a DT cord-009571-mygj2nd4 2104 6 ) ) -RRB- cord-009571-mygj2nd4 2104 7 a a DT cord-009571-mygj2nd4 2104 8 3 3 CD cord-009571-mygj2nd4 2104 9 to to TO cord-009571-mygj2nd4 2104 10 4-fold 4-fold CD cord-009571-mygj2nd4 2104 11 increase increase NN cord-009571-mygj2nd4 2104 12 in in IN cord-009571-mygj2nd4 2104 13 the the DT cord-009571-mygj2nd4 2104 14 apparent apparent JJ cord-009571-mygj2nd4 2104 15 Km km NN cord-009571-mygj2nd4 2104 16 for for IN cord-009571-mygj2nd4 2104 17 inosine inosine NN cord-009571-mygj2nd4 2104 18 , , , cord-009571-mygj2nd4 2104 19 and and CC cord-009571-mygj2nd4 2104 20 b b LS cord-009571-mygj2nd4 2104 21 ) ) -RRB- cord-009571-mygj2nd4 2104 22 only only RB cord-009571-mygj2nd4 2104 23 minor minor JJ cord-009571-mygj2nd4 2104 24 changes change NNS cord-009571-mygj2nd4 2104 25 in in IN cord-009571-mygj2nd4 2104 26 enzyme enzyme NN cord-009571-mygj2nd4 2104 27 activity activity NN cord-009571-mygj2nd4 2104 28 over over IN cord-009571-mygj2nd4 2104 29 a a DT cord-009571-mygj2nd4 2104 30 pH ph NN cord-009571-mygj2nd4 2104 31 range range NN cord-009571-mygj2nd4 2104 32 compared compare VBN cord-009571-mygj2nd4 2104 33 to to IN cord-009571-mygj2nd4 2104 34 normal normal JJ cord-009571-mygj2nd4 2104 35 . . . cord-009571-mygj2nd4 2105 1 These these DT cord-009571-mygj2nd4 2105 2 observations observation NNS cord-009571-mygj2nd4 2105 3 suggest suggest VBP cord-009571-mygj2nd4 2105 4 that that IN cord-009571-mygj2nd4 2105 5 a a LS cord-009571-mygj2nd4 2105 6 ) ) -RRB- cord-009571-mygj2nd4 2105 7 the the DT cord-009571-mygj2nd4 2105 8 degree degree NN cord-009571-mygj2nd4 2105 9 of of IN cord-009571-mygj2nd4 2105 10 abnormality abnormality NN cord-009571-mygj2nd4 2105 11 in in IN cord-009571-mygj2nd4 2105 12 uric uric NN cord-009571-mygj2nd4 2105 13 acid acid NN cord-009571-mygj2nd4 2105 14 and and CC cord-009571-mygj2nd4 2105 15 nucleoside nucleoside NN cord-009571-mygj2nd4 2105 16 concentrations concentration NNS cord-009571-mygj2nd4 2105 17 in in IN cord-009571-mygj2nd4 2105 18 the the DT cord-009571-mygj2nd4 2105 19 plasma plasma NN cord-009571-mygj2nd4 2105 20 and and CC cord-009571-mygj2nd4 2105 21 urine urine NN cord-009571-mygj2nd4 2105 22 reflect reflect VBP cord-009571-mygj2nd4 2105 23 the the DT cord-009571-mygj2nd4 2105 24 severity severity NN cord-009571-mygj2nd4 2105 25 of of IN cord-009571-mygj2nd4 2105 26 the the DT cord-009571-mygj2nd4 2105 27 enzymatic enzymatic JJ cord-009571-mygj2nd4 2105 28 deficiency deficiency NN cord-009571-mygj2nd4 2105 29 , , , cord-009571-mygj2nd4 2105 30 b b LS cord-009571-mygj2nd4 2105 31 ) ) -RRB- cord-009571-mygj2nd4 2105 32 structural structural JJ cord-009571-mygj2nd4 2105 33 alterations alteration NNS cord-009571-mygj2nd4 2105 34 of of IN cord-009571-mygj2nd4 2105 35 the the DT cord-009571-mygj2nd4 2105 36 mutant mutant JJ cord-009571-mygj2nd4 2105 37 PNP PNP NNP cord-009571-mygj2nd4 2105 38 proteins protein NNS cord-009571-mygj2nd4 2105 39 result result VBP cord-009571-mygj2nd4 2105 40 from from IN cord-009571-mygj2nd4 2105 41 structural structural JJ cord-009571-mygj2nd4 2105 42 gene gene NN cord-009571-mygj2nd4 2105 43 mutations mutation NNS cord-009571-mygj2nd4 2105 44 and and CC cord-009571-mygj2nd4 2105 45 genetic genetic JJ cord-009571-mygj2nd4 2105 46 heterogeneity heterogeneity NN cord-009571-mygj2nd4 2105 47 in in IN cord-009571-mygj2nd4 2105 48 the the DT cord-009571-mygj2nd4 2105 49 disease disease NN cord-009571-mygj2nd4 2105 50 PNP PNP NNP cord-009571-mygj2nd4 2105 51 deficiency deficiency NN cord-009571-mygj2nd4 2105 52 . . . cord-009571-mygj2nd4 2106 1 Since since IN cord-009571-mygj2nd4 2106 2 PNP PNP NNP cord-009571-mygj2nd4 2106 3 activity activity NN cord-009571-mygj2nd4 2106 4 was be VBD cord-009571-mygj2nd4 2106 5 found find VBN cord-009571-mygj2nd4 2106 6 in in IN cord-009571-mygj2nd4 2106 7 every every DT cord-009571-mygj2nd4 2106 8 human human JJ cord-009571-mygj2nd4 2106 9 tissue tissue NN cord-009571-mygj2nd4 2106 10 assayed assay VBN cord-009571-mygj2nd4 2106 11 , , , cord-009571-mygj2nd4 2106 12 the the DT cord-009571-mygj2nd4 2106 13 systemic systemic JJ cord-009571-mygj2nd4 2106 14 involvement involvement NN cord-009571-mygj2nd4 2106 15 of of IN cord-009571-mygj2nd4 2106 16 PNP PNP NNP cord-009571-mygj2nd4 2106 17 deficiency deficiency NN cord-009571-mygj2nd4 2106 18 can can MD cord-009571-mygj2nd4 2106 19 be be VB cord-009571-mygj2nd4 2106 20 accounted account VBN cord-009571-mygj2nd4 2106 21 for for IN cord-009571-mygj2nd4 2106 22 . . . cord-009571-mygj2nd4 2107 1 Recently recently RB cord-009571-mygj2nd4 2107 2 we -PRON- PRP cord-009571-mygj2nd4 2107 3 reported report VBD cord-009571-mygj2nd4 2107 4 the the DT cord-009571-mygj2nd4 2107 5 finding finding NN cord-009571-mygj2nd4 2107 6 of of IN cord-009571-mygj2nd4 2107 7 an an DT cord-009571-mygj2nd4 2107 8 antibody antibody NN cord-009571-mygj2nd4 2107 9 , , , cord-009571-mygj2nd4 2107 10 PM PM NNP cord-009571-mygj2nd4 2107 11 - - HYPH cord-009571-mygj2nd4 2107 12 I I NNP cord-009571-mygj2nd4 2107 13 , , , cord-009571-mygj2nd4 2107 14 directed direct VBN cord-009571-mygj2nd4 2107 15 toward toward IN cord-009571-mygj2nd4 2107 16 one one CD cord-009571-mygj2nd4 2107 17 of of IN cord-009571-mygj2nd4 2107 18 the the DT cord-009571-mygj2nd4 2107 19 nuclear nuclear JJ cord-009571-mygj2nd4 2107 20 acidic acidic JJ cord-009571-mygj2nd4 2107 21 protein protein NN cord-009571-mygj2nd4 2107 22 antigens antigen NNS cord-009571-mygj2nd4 2107 23 ( ( -LRB- cord-009571-mygj2nd4 2107 24 NAPA NAPA NNP cord-009571-mygj2nd4 2107 25 ) ) -RRB- cord-009571-mygj2nd4 2107 26 , , , cord-009571-mygj2nd4 2107 27 in in IN cord-009571-mygj2nd4 2107 28 sera sera NNP cord-009571-mygj2nd4 2107 29 of of IN cord-009571-mygj2nd4 2107 30 patients patient NNS cord-009571-mygj2nd4 2107 31 with with IN cord-009571-mygj2nd4 2107 32 polymyositis polymyositis NNP cord-009571-mygj2nd4 2107 33 . . . cord-009571-mygj2nd4 2108 1 This this DT cord-009571-mygj2nd4 2108 2 study study NN cord-009571-mygj2nd4 2108 3 was be VBD cord-009571-mygj2nd4 2108 4 undertaken undertake VBN cord-009571-mygj2nd4 2108 5 to to TO cord-009571-mygj2nd4 2108 6 investigate investigate VB cord-009571-mygj2nd4 2108 7 the the DT cord-009571-mygj2nd4 2108 8 relationship relationship NN cord-009571-mygj2nd4 2108 9 between between IN cord-009571-mygj2nd4 2108 10 PM pm NN cord-009571-mygj2nd4 2108 11 - - HYPH cord-009571-mygj2nd4 2108 12 I I NNP cord-009571-mygj2nd4 2108 13 antibody antibody NN cord-009571-mygj2nd4 2108 14 , , , cord-009571-mygj2nd4 2108 15 polymyositis polymyositis NN cord-009571-mygj2nd4 2108 16 syndromes syndrome NNS cord-009571-mygj2nd4 2108 17 , , , cord-009571-mygj2nd4 2108 18 and and CC cord-009571-mygj2nd4 2108 19 other other JJ cord-009571-mygj2nd4 2108 20 rheumatic rheumatic JJ cord-009571-mygj2nd4 2108 21 diseases disease NNS cord-009571-mygj2nd4 2108 22 . . . cord-009571-mygj2nd4 2109 1 Sera Sera NNP cord-009571-mygj2nd4 2109 2 were be VBD cord-009571-mygj2nd4 2109 3 tested test VBN cord-009571-mygj2nd4 2109 4 against against IN cord-009571-mygj2nd4 2109 5 nuclear nuclear JJ cord-009571-mygj2nd4 2109 6 extracts extract NNS cord-009571-mygj2nd4 2109 7 by by IN cord-009571-mygj2nd4 2109 8 immunodiffusion immunodiffusion NN cord-009571-mygj2nd4 2109 9 and and CC cord-009571-mygj2nd4 2109 10 counterimmunoelectrophoresis counterimmunoelectrophoresis NN cord-009571-mygj2nd4 2109 11 for for IN cord-009571-mygj2nd4 2109 12 the the DT cord-009571-mygj2nd4 2109 13 presence presence NN cord-009571-mygj2nd4 2109 14 of of IN cord-009571-mygj2nd4 2109 15 antibodies antibody NNS cord-009571-mygj2nd4 2109 16 to to IN cord-009571-mygj2nd4 2109 17 PM-1 PM-1 NNP cord-009571-mygj2nd4 2109 18 and and CC cord-009571-mygj2nd4 2109 19 other other JJ cord-009571-mygj2nd4 2109 20 NAPA NAPA NNP cord-009571-mygj2nd4 2109 21 . . . cord-009571-mygj2nd4 2110 1 Clinical clinical JJ cord-009571-mygj2nd4 2110 2 data datum NNS cord-009571-mygj2nd4 2110 3 were be VBD cord-009571-mygj2nd4 2110 4 then then RB cord-009571-mygj2nd4 2110 5 obtained obtain VBN cord-009571-mygj2nd4 2110 6 and and CC cord-009571-mygj2nd4 2110 7 analyzed analyze VBN cord-009571-mygj2nd4 2110 8 . . . cord-009571-mygj2nd4 2111 1 Fifty fifty CD cord-009571-mygj2nd4 2111 2 - - HYPH cord-009571-mygj2nd4 2111 3 two two CD cord-009571-mygj2nd4 2111 4 patients patient NNS cord-009571-mygj2nd4 2111 5 were be VBD cord-009571-mygj2nd4 2111 6 identified identify VBN cord-009571-mygj2nd4 2111 7 who who WP cord-009571-mygj2nd4 2111 8 had have VBD cord-009571-mygj2nd4 2111 9 polymyositis polymyositis NN cord-009571-mygj2nd4 2111 10 syndromes syndrome NNS cord-009571-mygj2nd4 2111 11 as as IN cord-009571-mygj2nd4 2111 12 defined define VBN cord-009571-mygj2nd4 2111 13 by by IN cord-009571-mygj2nd4 2111 14 significant significant JJ cord-009571-mygj2nd4 2111 15 muscle muscle NN cord-009571-mygj2nd4 2111 16 weakness weakness NN cord-009571-mygj2nd4 2111 17 , , , cord-009571-mygj2nd4 2111 18 elevated elevated JJ cord-009571-mygj2nd4 2111 19 serum serum NN cord-009571-mygj2nd4 2111 20 muscle muscle NN cord-009571-mygj2nd4 2111 21 enzymes enzyme NNS cord-009571-mygj2nd4 2111 22 , , , cord-009571-mygj2nd4 2111 23 myopathic myopathic NNP cord-009571-mygj2nd4 2111 24 electromyogram electromyogram NNP cord-009571-mygj2nd4 2111 25 , , , cord-009571-mygj2nd4 2111 26 and and CC cord-009571-mygj2nd4 2111 27 muscle muscle NN cord-009571-mygj2nd4 2111 28 biopsy biopsy NN cord-009571-mygj2nd4 2111 29 typical typical JJ cord-009571-mygj2nd4 2111 30 of of IN cord-009571-mygj2nd4 2111 31 polymyositis polymyositis NNP cord-009571-mygj2nd4 2111 32 . . . cord-009571-mygj2nd4 2112 1 Of of IN cord-009571-mygj2nd4 2112 2 these these DT cord-009571-mygj2nd4 2112 3 , , , cord-009571-mygj2nd4 2112 4 24 24 CD cord-009571-mygj2nd4 2112 5 had have VBD cord-009571-mygj2nd4 2112 6 polymyositis polymyositis NN cord-009571-mygj2nd4 2112 7 , , , cord-009571-mygj2nd4 2112 8 18 18 CD cord-009571-mygj2nd4 2112 9 had have VBD cord-009571-mygj2nd4 2112 10 polymyositis polymyositis NN cord-009571-mygj2nd4 2112 11 - - HYPH cord-009571-mygj2nd4 2112 12 scleroderma scleroderma NN cord-009571-mygj2nd4 2112 13 overlap overlap VBP cord-009571-mygj2nd4 2112 14 , , , cord-009571-mygj2nd4 2112 15 and and CC cord-009571-mygj2nd4 2112 16 10 10 CD cord-009571-mygj2nd4 2112 17 had have VBD cord-009571-mygj2nd4 2112 18 derrnatomyositis derrnatomyositis NNP cord-009571-mygj2nd4 2112 19 . . . cord-009571-mygj2nd4 2113 1 PM pm NN cord-009571-mygj2nd4 2113 2 - - HYPH cord-009571-mygj2nd4 2113 3 I i NN cord-009571-mygj2nd4 2113 4 antibody antibody NN cord-009571-mygj2nd4 2113 5 was be VBD cord-009571-mygj2nd4 2113 6 found find VBN cord-009571-mygj2nd4 2113 7 in in IN cord-009571-mygj2nd4 2113 8 50 50 CD cord-009571-mygj2nd4 2113 9 % % NN cord-009571-mygj2nd4 2113 10 of of IN cord-009571-mygj2nd4 2113 11 polymyositis polymyositis NN cord-009571-mygj2nd4 2113 12 , , , cord-009571-mygj2nd4 2113 13 73 73 CD cord-009571-mygj2nd4 2113 14 % % NN cord-009571-mygj2nd4 2113 15 of of IN cord-009571-mygj2nd4 2113 16 polymyositis polymyositis NN cord-009571-mygj2nd4 2113 17 - - HYPH cord-009571-mygj2nd4 2113 18 scleroderma scleroderma NNS cord-009571-mygj2nd4 2113 19 , , , cord-009571-mygj2nd4 2113 20 and and CC cord-009571-mygj2nd4 2113 21 20 20 CD cord-009571-mygj2nd4 2113 22 % % NN cord-009571-mygj2nd4 2113 23 of of IN cord-009571-mygj2nd4 2113 24 dermatomyositis dermatomyositis NN cord-009571-mygj2nd4 2113 25 . . . cord-009571-mygj2nd4 2114 1 polymyositis polymyositis NNP cord-009571-mygj2nd4 2114 2 syndromes syndrome NNS cord-009571-mygj2nd4 2114 3 , , , cord-009571-mygj2nd4 2114 4 a a DT cord-009571-mygj2nd4 2114 5 difference difference NN cord-009571-mygj2nd4 2114 6 in in IN cord-009571-mygj2nd4 2114 7 the the DT cord-009571-mygj2nd4 2114 8 prevalence prevalence NN cord-009571-mygj2nd4 2114 9 of of IN cord-009571-mygj2nd4 2114 10 the the DT cord-009571-mygj2nd4 2114 11 clinical clinical JJ cord-009571-mygj2nd4 2114 12 characteristics characteristic NNS cord-009571-mygj2nd4 2114 13 was be VBD cord-009571-mygj2nd4 2114 14 noted note VBN cord-009571-mygj2nd4 2114 15 as as IN cord-009571-mygj2nd4 2114 16 shown show VBN cord-009571-mygj2nd4 2114 17 in in IN cord-009571-mygj2nd4 2114 18 the the DT cord-009571-mygj2nd4 2114 19 table table NN cord-009571-mygj2nd4 2114 20 . . . cord-009571-mygj2nd4 2115 1 Blinded blinded JJ cord-009571-mygj2nd4 2115 2 serum serum NN cord-009571-mygj2nd4 2115 3 exchanges exchange NNS cord-009571-mygj2nd4 2115 4 of of IN cord-009571-mygj2nd4 2115 5 58 58 CD cord-009571-mygj2nd4 2115 6 sera serum NNS cord-009571-mygj2nd4 2115 7 between between IN cord-009571-mygj2nd4 2115 8 3 3 CD cord-009571-mygj2nd4 2115 9 medical medical JJ cord-009571-mygj2nd4 2115 10 centers center NNS cord-009571-mygj2nd4 2115 11 revealed reveal VBD cord-009571-mygj2nd4 2115 12 the the DT cord-009571-mygj2nd4 2115 13 prevalence prevalence NN cord-009571-mygj2nd4 2115 14 of of IN cord-009571-mygj2nd4 2115 15 the the DT cord-009571-mygj2nd4 2115 16 PM pm NN cord-009571-mygj2nd4 2115 17 - - HYPH cord-009571-mygj2nd4 2115 18 I -PRON- PRP cord-009571-mygj2nd4 2115 19 antibody antibody NN cord-009571-mygj2nd4 2115 20 to to TO cord-009571-mygj2nd4 2115 21 be be VB cord-009571-mygj2nd4 2115 22 25 25 CD cord-009571-mygj2nd4 2115 23 % % NN cord-009571-mygj2nd4 2115 24 in in IN cord-009571-mygj2nd4 2115 25 childhood childhood NN cord-009571-mygj2nd4 2115 26 dermatomyositis dermatomyositis NNP cord-009571-mygj2nd4 2115 27 ( ( -LRB- cord-009571-mygj2nd4 2115 28 4 4 CD cord-009571-mygj2nd4 2115 29 of of IN cord-009571-mygj2nd4 2115 30 16 16 CD cord-009571-mygj2nd4 2115 31 ) ) -RRB- cord-009571-mygj2nd4 2115 32 , , , cord-009571-mygj2nd4 2115 33 17 17 CD cord-009571-mygj2nd4 2115 34 % % NN cord-009571-mygj2nd4 2115 35 in in IN cord-009571-mygj2nd4 2115 36 adult adult NN cord-009571-mygj2nd4 2115 37 dermatomyositis dermatomyositis NNP cord-009571-mygj2nd4 2115 38 ( ( -LRB- cord-009571-mygj2nd4 2115 39 3 3 CD cord-009571-mygj2nd4 2115 40 of of IN cord-009571-mygj2nd4 2115 41 18 18 CD cord-009571-mygj2nd4 2115 42 ) ) -RRB- cord-009571-mygj2nd4 2115 43 . . . cord-009571-mygj2nd4 2116 1 and and CC cord-009571-mygj2nd4 2116 2 38 38 CD cord-009571-mygj2nd4 2116 3 % % NN cord-009571-mygj2nd4 2116 4 in in IN cord-009571-mygj2nd4 2116 5 polymyositis polymyositis NN cord-009571-mygj2nd4 2116 6 ( ( -LRB- cord-009571-mygj2nd4 2116 7 3 3 CD cord-009571-mygj2nd4 2116 8 of of IN cord-009571-mygj2nd4 2116 9 8) 8) CD cord-009571-mygj2nd4 2116 10 . . . cord-009571-mygj2nd4 2117 1 Patients patient NNS cord-009571-mygj2nd4 2117 2 with with IN cord-009571-mygj2nd4 2117 3 other other JJ cord-009571-mygj2nd4 2117 4 rheumatic rheumatic JJ cord-009571-mygj2nd4 2117 5 diseases disease NNS cord-009571-mygj2nd4 2117 6 were be VBD cord-009571-mygj2nd4 2117 7 negative negative JJ cord-009571-mygj2nd4 2117 8 for for IN cord-009571-mygj2nd4 2117 9 PM pm NN cord-009571-mygj2nd4 2117 10 - - HYPH cord-009571-mygj2nd4 2117 11 I i NN cord-009571-mygj2nd4 2117 12 antibody antibody NN cord-009571-mygj2nd4 2117 13 ( ( -LRB- cord-009571-mygj2nd4 2117 14 0 0 CD cord-009571-mygj2nd4 2117 15 of of IN cord-009571-mygj2nd4 2117 16 16 16 CD cord-009571-mygj2nd4 2117 17 ) ) -RRB- cord-009571-mygj2nd4 2117 18 . . . cord-009571-mygj2nd4 2118 1 We -PRON- PRP cord-009571-mygj2nd4 2118 2 conclude conclude VBP cord-009571-mygj2nd4 2118 3 that that IN cord-009571-mygj2nd4 2118 4 the the DT cord-009571-mygj2nd4 2118 5 PM PM NNP cord-009571-mygj2nd4 2118 6 - - HYPH cord-009571-mygj2nd4 2118 7 I -PRON- PRP cord-009571-mygj2nd4 2118 8 antibody antibody NN cord-009571-mygj2nd4 2118 9 has have VBZ cord-009571-mygj2nd4 2118 10 a a DT cord-009571-mygj2nd4 2118 11 high high JJ cord-009571-mygj2nd4 2118 12 specificity specificity NN cord-009571-mygj2nd4 2118 13 for for IN cord-009571-mygj2nd4 2118 14 polymyositis polymyositis NN cord-009571-mygj2nd4 2118 15 and and CC cord-009571-mygj2nd4 2118 16 that that IN cord-009571-mygj2nd4 2118 17 it -PRON- PRP cord-009571-mygj2nd4 2118 18 may may MD cord-009571-mygj2nd4 2118 19 identify identify VB cord-009571-mygj2nd4 2118 20 a a DT cord-009571-mygj2nd4 2118 21 subset subset NN cord-009571-mygj2nd4 2118 22 of of IN cord-009571-mygj2nd4 2118 23 polymyositis polymyositis NN cord-009571-mygj2nd4 2118 24 patients patient NNS cord-009571-mygj2nd4 2118 25 who who WP cord-009571-mygj2nd4 2118 26 have have VBP cord-009571-mygj2nd4 2118 27 other other JJ cord-009571-mygj2nd4 2118 28 connective connective JJ cord-009571-mygj2nd4 2118 29 tissue tissue NN cord-009571-mygj2nd4 2118 30 disease disease NN cord-009571-mygj2nd4 2118 31 manifestations manifestation NNS cord-009571-mygj2nd4 2118 32 . . . cord-009571-mygj2nd4 2119 1 PM pm NN cord-009571-mygj2nd4 2119 2 - - HYPH cord-009571-mygj2nd4 2119 3 I I NNP cord-009571-mygj2nd4 2119 4 Positive positive JJ cord-009571-mygj2nd4 2119 5 PM pm NN cord-009571-mygj2nd4 2119 6 - - : cord-009571-mygj2nd4 2119 7 I I NNP cord-009571-mygj2nd4 2119 8 Negative Negative NNP cord-009571-mygj2nd4 2119 9 Clinical Clinical NNP cord-009571-mygj2nd4 2119 10 Characteristic Characteristic NNP cord-009571-mygj2nd4 2119 11 n n NNP cord-009571-mygj2nd4 2119 12 = = SYM cord-009571-mygj2nd4 2119 13 21 21 CD cord-009571-mygj2nd4 2119 14 n n NN cord-009571-mygj2nd4 2119 15 = = SYM cord-009571-mygj2nd4 2119 16 25 25 CD cord-009571-mygj2nd4 2119 17 The the DT cord-009571-mygj2nd4 2119 18 PM-1 PM-1 NNP cord-009571-mygj2nd4 2119 19 antibody antibody NN cord-009571-mygj2nd4 2119 20 was be VBD cord-009571-mygj2nd4 2119 21 found find VBN cord-009571-mygj2nd4 2119 22 rarely rarely RB cord-009571-mygj2nd4 2119 23 ( ( -LRB- cord-009571-mygj2nd4 2119 24 < < XX cord-009571-mygj2nd4 2120 1 I -PRON- PRP cord-009571-mygj2nd4 2120 2 % % NN cord-009571-mygj2nd4 2120 3 ) ) -RRB- cord-009571-mygj2nd4 2120 4 in in IN cord-009571-mygj2nd4 2120 5 lo00 lo00 NNP cord-009571-mygj2nd4 2120 6 patients patient NNS cord-009571-mygj2nd4 2120 7 other other JJ cord-009571-mygj2nd4 2120 8 muscular muscular JJ cord-009571-mygj2nd4 2120 9 disorders disorder NNS cord-009571-mygj2nd4 2120 10 such such JJ cord-009571-mygj2nd4 2120 11 as as IN cord-009571-mygj2nd4 2120 12 myasthenia myasthenia NN cord-009571-mygj2nd4 2120 13 gravis gravis NN cord-009571-mygj2nd4 2120 14 , , , cord-009571-mygj2nd4 2120 15 muscular muscular JJ cord-009571-mygj2nd4 2120 16 Pulmonary pulmonary JJ cord-009571-mygj2nd4 2120 17 disease disease NN cord-009571-mygj2nd4 2120 18 dystrophy dystrophy NN cord-009571-mygj2nd4 2120 19 , , , cord-009571-mygj2nd4 2120 20 and and CC cord-009571-mygj2nd4 2120 21 polymyalgia polymyalgia NNP cord-009571-mygj2nd4 2120 22 rheumatica rheumatica NNP cord-009571-mygj2nd4 2120 23 . . . cord-009571-mygj2nd4 2121 1 Among among IN cord-009571-mygj2nd4 2121 2 patients patient NNS cord-009571-mygj2nd4 2121 3 with with IN cord-009571-mygj2nd4 2121 4 An an DT cord-009571-mygj2nd4 2121 5 association association NN cord-009571-mygj2nd4 2121 6 between between IN cord-009571-mygj2nd4 2121 7 viral viral JJ cord-009571-mygj2nd4 2121 8 infection infection NN cord-009571-mygj2nd4 2121 9 and and CC cord-009571-mygj2nd4 2121 10 joint joint JJ cord-009571-mygj2nd4 2121 11 inflammation inflammation NN cord-009571-mygj2nd4 2121 12 has have VBZ cord-009571-mygj2nd4 2121 13 repeatedly repeatedly RB cord-009571-mygj2nd4 2121 14 been be VBN cord-009571-mygj2nd4 2121 15 reported report VBN cord-009571-mygj2nd4 2121 16 . . . cord-009571-mygj2nd4 2122 1 Our -PRON- PRP$ cord-009571-mygj2nd4 2122 2 recent recent JJ cord-009571-mygj2nd4 2122 3 studies study NNS cord-009571-mygj2nd4 2122 4 showed show VBD cord-009571-mygj2nd4 2122 5 that that IN cord-009571-mygj2nd4 2122 6 interferon interferon NN cord-009571-mygj2nd4 2122 7 inducer inducer NN cord-009571-mygj2nd4 2122 8 , , , cord-009571-mygj2nd4 2122 9 double double JJ cord-009571-mygj2nd4 2122 10 stranded strand VBN cord-009571-mygj2nd4 2122 11 polyinosinate polyinosinate NN cord-009571-mygj2nd4 2122 12 - - HYPH cord-009571-mygj2nd4 2122 13 polycytidylate polycytidylate NNP cord-009571-mygj2nd4 2122 14 ( ( -LRB- cord-009571-mygj2nd4 2122 15 Poly Poly NNP cord-009571-mygj2nd4 2122 16 l l NN cord-009571-mygj2nd4 2122 17 : : : cord-009571-mygj2nd4 2122 18 C C NNP cord-009571-mygj2nd4 2122 19 ) ) -RRB- cord-009571-mygj2nd4 2122 20 , , , cord-009571-mygj2nd4 2122 21 as as RB cord-009571-mygj2nd4 2122 22 well well RB cord-009571-mygj2nd4 2122 23 as as IN cord-009571-mygj2nd4 2122 24 human human JJ cord-009571-mygj2nd4 2122 25 interferon interferon NN cord-009571-mygj2nd4 2122 26 , , , cord-009571-mygj2nd4 2122 27 stimulated stimulate VBD cord-009571-mygj2nd4 2122 28 both both DT cord-009571-mygj2nd4 2122 29 prostaglandin prostaglandin NN cord-009571-mygj2nd4 2122 30 E e NN cord-009571-mygj2nd4 2122 31 ( ( -LRB- cord-009571-mygj2nd4 2122 32 PGE PGE NNP cord-009571-mygj2nd4 2122 33 ) ) -RRB- cord-009571-mygj2nd4 2122 34 and and CC cord-009571-mygj2nd4 2122 35 hyaluronic hyaluronic NN cord-009571-mygj2nd4 2122 36 acid acid NN cord-009571-mygj2nd4 2122 37 production production NN cord-009571-mygj2nd4 2122 38 by by IN cord-009571-mygj2nd4 2122 39 human human JJ cord-009571-mygj2nd4 2122 40 cultured cultured JJ cord-009571-mygj2nd4 2122 41 synovial synovial JJ cord-009571-mygj2nd4 2122 42 fibroblasts fibroblast NNS cord-009571-mygj2nd4 2122 43 . . . cord-009571-mygj2nd4 2123 1 The the DT cord-009571-mygj2nd4 2123 2 present present JJ cord-009571-mygj2nd4 2123 3 study study NN cord-009571-mygj2nd4 2123 4 was be VBD cord-009571-mygj2nd4 2123 5 performed perform VBN cord-009571-mygj2nd4 2123 6 in in IN cord-009571-mygj2nd4 2123 7 order order NN cord-009571-mygj2nd4 2123 8 to to TO cord-009571-mygj2nd4 2123 9 evaluate evaluate VB cord-009571-mygj2nd4 2123 10 further further JJ cord-009571-mygj2nd4 2123 11 the the DT cord-009571-mygj2nd4 2123 12 role role NN cord-009571-mygj2nd4 2123 13 of of IN cord-009571-mygj2nd4 2123 14 interferon interferon NN cord-009571-mygj2nd4 2123 15 and and CC cord-009571-mygj2nd4 2123 16 Poly Poly NNP cord-009571-mygj2nd4 2123 17 I I NNP cord-009571-mygj2nd4 2123 18 : : : cord-009571-mygj2nd4 2123 19 C c NN cord-009571-mygj2nd4 2123 20 in in IN cord-009571-mygj2nd4 2123 21 joint joint JJ cord-009571-mygj2nd4 2123 22 inflammation inflammation NN cord-009571-mygj2nd4 2123 23 . . . cord-009571-mygj2nd4 2124 1 Polynucleotides polynucleotide NNS cord-009571-mygj2nd4 2124 2 , , , cord-009571-mygj2nd4 2124 3 mouse mouse NN cord-009571-mygj2nd4 2124 4 interferon interferon NN cord-009571-mygj2nd4 2124 5 , , , cord-009571-mygj2nd4 2124 6 or or CC cord-009571-mygj2nd4 2124 7 phosphate phosphate NN cord-009571-mygj2nd4 2124 8 buffered buffer VBN cord-009571-mygj2nd4 2124 9 saline saline NN cord-009571-mygj2nd4 2124 10 were be VBD cord-009571-mygj2nd4 2124 11 injected inject VBN cord-009571-mygj2nd4 2124 12 intraarticularly intraarticularly RB cord-009571-mygj2nd4 2124 13 in in IN cord-009571-mygj2nd4 2124 14 10-week 10-week JJ cord-009571-mygj2nd4 2124 15 - - HYPH cord-009571-mygj2nd4 2124 16 old old JJ cord-009571-mygj2nd4 2124 17 Wistar Wistar NNP cord-009571-mygj2nd4 2124 18 derived derive VBD cord-009571-mygj2nd4 2124 19 male male JJ cord-009571-mygj2nd4 2124 20 rats rat NNS cord-009571-mygj2nd4 2124 21 by by IN cord-009571-mygj2nd4 2124 22 methods method NNS cord-009571-mygj2nd4 2124 23 previously previously RB cord-009571-mygj2nd4 2124 24 described describe VBN cord-009571-mygj2nd4 2124 25 . . . cord-009571-mygj2nd4 2125 1 Animals animal NNS cord-009571-mygj2nd4 2125 2 were be VBD cord-009571-mygj2nd4 2125 3 killed kill VBN cord-009571-mygj2nd4 2125 4 24 24 CD cord-009571-mygj2nd4 2125 5 hours hour NNS cord-009571-mygj2nd4 2125 6 later later RB cord-009571-mygj2nd4 2125 7 and and CC cord-009571-mygj2nd4 2125 8 the the DT cord-009571-mygj2nd4 2125 9 synovia synovia NNP cord-009571-mygj2nd4 2125 10 were be VBD cord-009571-mygj2nd4 2125 11 removed remove VBN cord-009571-mygj2nd4 2125 12 for for IN cord-009571-mygj2nd4 2125 13 histological histological JJ cord-009571-mygj2nd4 2125 14 examination examination NN cord-009571-mygj2nd4 2125 15 and and CC cord-009571-mygj2nd4 2125 16 determination determination NN cord-009571-mygj2nd4 2125 17 of of IN cord-009571-mygj2nd4 2125 18 PGE PGE NNP cord-009571-mygj2nd4 2125 19 . . . cord-009571-mygj2nd4 2126 1 Injection injection NN cord-009571-mygj2nd4 2126 2 of of IN cord-009571-mygj2nd4 2126 3 Poly Poly NNP cord-009571-mygj2nd4 2126 4 I I NNP cord-009571-mygj2nd4 2126 5 : : : cord-009571-mygj2nd4 2126 6 C c NN cord-009571-mygj2nd4 2126 7 or or CC cord-009571-mygj2nd4 2126 8 mouse mouse NN cord-009571-mygj2nd4 2127 1 interferon interferon NNP cord-009571-mygj2nd4 2127 2 induced induce VBD cord-009571-mygj2nd4 2127 3 an an DT cord-009571-mygj2nd4 2127 4 inflammatory inflammatory JJ cord-009571-mygj2nd4 2127 5 response response NN cord-009571-mygj2nd4 2127 6 . . . cord-009571-mygj2nd4 2128 1 Poly Poly NNP cord-009571-mygj2nd4 2128 2 A A NNP cord-009571-mygj2nd4 2128 3 : : : cord-009571-mygj2nd4 2128 4 U U NNP cord-009571-mygj2nd4 2128 5 was be VBD cord-009571-mygj2nd4 2128 6 only only RB cord-009571-mygj2nd4 2128 7 slightly slightly RB cord-009571-mygj2nd4 2128 8 active active JJ cord-009571-mygj2nd4 2128 9 in in IN cord-009571-mygj2nd4 2128 10 this this DT cord-009571-mygj2nd4 2128 11 respect respect NN cord-009571-mygj2nd4 2128 12 . . . cord-009571-mygj2nd4 2129 1 By by IN cord-009571-mygj2nd4 2129 2 contrast contrast NN cord-009571-mygj2nd4 2129 3 , , , cord-009571-mygj2nd4 2129 4 PBS PBS NNP cord-009571-mygj2nd4 2129 5 or or CC cord-009571-mygj2nd4 2129 6 single single JJ cord-009571-mygj2nd4 2129 7 stranded strand VBN cord-009571-mygj2nd4 2129 8 polyinosinate polyinosinate NN cord-009571-mygj2nd4 2129 9 ( ( -LRB- cord-009571-mygj2nd4 2129 10 Poly Poly NNP cord-009571-mygj2nd4 2129 11 ( ( -LRB- cord-009571-mygj2nd4 2129 12 I i NN cord-009571-mygj2nd4 2129 13 ) ) -RRB- cord-009571-mygj2nd4 2129 14 ) ) -RRB- cord-009571-mygj2nd4 2129 15 or or CC cord-009571-mygj2nd4 2129 16 polycytidylate polycytidylate NNP cord-009571-mygj2nd4 2129 17 ( ( -LRB- cord-009571-mygj2nd4 2129 18 Poly Poly NNP cord-009571-mygj2nd4 2129 19 ( ( -LRB- cord-009571-mygj2nd4 2129 20 C C NNP cord-009571-mygj2nd4 2129 21 ) ) -RRB- cord-009571-mygj2nd4 2129 22 ) ) -RRB- cord-009571-mygj2nd4 2129 23 did do VBD cord-009571-mygj2nd4 2129 24 not not RB cord-009571-mygj2nd4 2129 25 induce induce VB cord-009571-mygj2nd4 2129 26 any any DT cord-009571-mygj2nd4 2129 27 significant significant JJ cord-009571-mygj2nd4 2129 28 inflammatory inflammatory JJ cord-009571-mygj2nd4 2129 29 response response NN cord-009571-mygj2nd4 2129 30 . . . cord-009571-mygj2nd4 2130 1 Rat rat NN cord-009571-mygj2nd4 2130 2 knee knee NN cord-009571-mygj2nd4 2130 3 joints joint NNS cord-009571-mygj2nd4 2130 4 injected inject VBN cord-009571-mygj2nd4 2130 5 with with IN cord-009571-mygj2nd4 2130 6 either either DT cord-009571-mygj2nd4 2130 7 Poly Poly NNP cord-009571-mygj2nd4 2130 8 I i NN cord-009571-mygj2nd4 2130 9 : : : cord-009571-mygj2nd4 2130 10 C C NNP cord-009571-mygj2nd4 2130 11 ( ( -LRB- cord-009571-mygj2nd4 2130 12 50 50 CD cord-009571-mygj2nd4 2130 13 , , , cord-009571-mygj2nd4 2130 14 100 100 CD cord-009571-mygj2nd4 2130 15 , , , cord-009571-mygj2nd4 2130 16 or or CC cord-009571-mygj2nd4 2130 17 250 250 CD cord-009571-mygj2nd4 2130 18 pg pg NN cord-009571-mygj2nd4 2130 19 / / SYM cord-009571-mygj2nd4 2130 20 joint joint NN cord-009571-mygj2nd4 2130 21 ) ) -RRB- cord-009571-mygj2nd4 2130 22 or or CC cord-009571-mygj2nd4 2130 23 interferon interferon NN cord-009571-mygj2nd4 2131 1 ( ( -LRB- cord-009571-mygj2nd4 2131 2 500 500 CD cord-009571-mygj2nd4 2131 3 or or CC cord-009571-mygj2nd4 2131 4 lo00 lo00 NNP cord-009571-mygj2nd4 2131 5 p p NN cord-009571-mygj2nd4 2131 6 / / SYM cord-009571-mygj2nd4 2131 7 joint joint NN cord-009571-mygj2nd4 2131 8 ) ) -RRB- cord-009571-mygj2nd4 2131 9 , , , cord-009571-mygj2nd4 2131 10 appeared appear VBD cord-009571-mygj2nd4 2131 11 macroscopically macroscopically RB cord-009571-mygj2nd4 2131 12 swollen swollen JJ cord-009571-mygj2nd4 2131 13 and and CC cord-009571-mygj2nd4 2131 14 edematous edematous JJ cord-009571-mygj2nd4 2131 15 and and CC cord-009571-mygj2nd4 2131 16 contained contain VBD cord-009571-mygj2nd4 2131 17 an an DT cord-009571-mygj2nd4 2131 18 increased increase VBN cord-009571-mygj2nd4 2131 19 amount amount NN cord-009571-mygj2nd4 2131 20 of of IN cord-009571-mygj2nd4 2131 21 viscous viscous JJ cord-009571-mygj2nd4 2131 22 fluid fluid NN cord-009571-mygj2nd4 2131 23 . . . cord-009571-mygj2nd4 2132 1 Microscopically microscopically RB cord-009571-mygj2nd4 2132 2 inflamed inflame VBN cord-009571-mygj2nd4 2132 3 synovium synovium NN cord-009571-mygj2nd4 2132 4 contained contain VBD cord-009571-mygj2nd4 2132 5 variable variable JJ cord-009571-mygj2nd4 2132 6 amounts amount NNS cord-009571-mygj2nd4 2132 7 of of IN cord-009571-mygj2nd4 2132 8 inflammatory inflammatory JJ cord-009571-mygj2nd4 2132 9 cells cell NNS cord-009571-mygj2nd4 2132 10 , , , cord-009571-mygj2nd4 2132 11 most most JJS cord-009571-mygj2nd4 2132 12 of of IN cord-009571-mygj2nd4 2132 13 them -PRON- PRP cord-009571-mygj2nd4 2132 14 polymorphonu polymorphonu NNP cord-009571-mygj2nd4 2132 15 - - HYPH cord-009571-mygj2nd4 2132 16 clear clear JJ cord-009571-mygj2nd4 2132 17 . . . cord-009571-mygj2nd4 2133 1 Synovial Synovial NNP cord-009571-mygj2nd4 2133 2 PGE PGE NNP cord-009571-mygj2nd4 2133 3 levels level NNS cord-009571-mygj2nd4 2133 4 were be VBD cord-009571-mygj2nd4 2133 5 increased increase VBN cord-009571-mygj2nd4 2133 6 by by IN cord-009571-mygj2nd4 2133 7 Poly Poly NNP cord-009571-mygj2nd4 2133 8 I I NNP cord-009571-mygj2nd4 2133 9 : : : cord-009571-mygj2nd4 2133 10 C C NNP cord-009571-mygj2nd4 2133 11 , , , cord-009571-mygj2nd4 2133 12 Poly Poly NNP cord-009571-mygj2nd4 2133 13 A A NNP cord-009571-mygj2nd4 2133 14 : : : cord-009571-mygj2nd4 2133 15 U U NNP cord-009571-mygj2nd4 2133 16 , , , cord-009571-mygj2nd4 2133 17 and and CC cord-009571-mygj2nd4 2133 18 interferon interferon NN cord-009571-mygj2nd4 2133 19 but but CC cord-009571-mygj2nd4 2133 20 not not RB cord-009571-mygj2nd4 2133 21 by by IN cord-009571-mygj2nd4 2133 22 Poly Poly NNP cord-009571-mygj2nd4 2133 23 ( ( -LRB- cord-009571-mygj2nd4 2133 24 I i NN cord-009571-mygj2nd4 2133 25 ) ) -RRB- cord-009571-mygj2nd4 2133 26 or or CC cord-009571-mygj2nd4 2133 27 Poly Poly NNP cord-009571-mygj2nd4 2133 28 ( ( -LRB- cord-009571-mygj2nd4 2133 29 C C NNP cord-009571-mygj2nd4 2133 30 ) ) -RRB- cord-009571-mygj2nd4 2133 31 . . . cord-009571-mygj2nd4 2134 1 Mouse mouse NN cord-009571-mygj2nd4 2134 2 interferon interferon NN cord-009571-mygj2nd4 2134 3 also also RB cord-009571-mygj2nd4 2134 4 induced induce VBD cord-009571-mygj2nd4 2134 5 an an DT cord-009571-mygj2nd4 2134 6 inflammatory inflammatory JJ cord-009571-mygj2nd4 2134 7 response response NN cord-009571-mygj2nd4 2134 8 when when WRB cord-009571-mygj2nd4 2134 9 injected inject VBN cord-009571-mygj2nd4 2134 10 in in IN cord-009571-mygj2nd4 2134 11 mouse mouse NN cord-009571-mygj2nd4 2134 12 knee knee NN cord-009571-mygj2nd4 2134 13 joint joint NN cord-009571-mygj2nd4 2134 14 . . . cord-009571-mygj2nd4 2135 1 We -PRON- PRP cord-009571-mygj2nd4 2135 2 suggest suggest VBP cord-009571-mygj2nd4 2135 3 that that IN cord-009571-mygj2nd4 2135 4 interferon interferon NN cord-009571-mygj2nd4 2135 5 may may MD cord-009571-mygj2nd4 2135 6 be be VB cord-009571-mygj2nd4 2135 7 a a DT cord-009571-mygj2nd4 2135 8 mediator mediator NN cord-009571-mygj2nd4 2135 9 in in IN cord-009571-mygj2nd4 2135 10 the the DT cord-009571-mygj2nd4 2135 11 initiation initiation NN cord-009571-mygj2nd4 2135 12 of of IN cord-009571-mygj2nd4 2135 13 inflammation inflammation NN cord-009571-mygj2nd4 2135 14 by by IN cord-009571-mygj2nd4 2135 15 viruses virus NNS cord-009571-mygj2nd4 2135 16 . . . cord-009571-mygj2nd4 2136 1 Nineteen nineteen CD cord-009571-mygj2nd4 2136 2 patients patient NNS cord-009571-mygj2nd4 2136 3 with with IN cord-009571-mygj2nd4 2136 4 musculoskeletal musculoskeletal JJ cord-009571-mygj2nd4 2136 5 complaints complaint NNS cord-009571-mygj2nd4 2136 6 after after IN cord-009571-mygj2nd4 2136 7 jejuno jejuno NNP cord-009571-mygj2nd4 2136 8 - - HYPH cord-009571-mygj2nd4 2136 9 ileal ileal JJ cord-009571-mygj2nd4 2136 10 bypass bypass NN cord-009571-mygj2nd4 2136 11 for for IN cord-009571-mygj2nd4 2136 12 morbid morbid JJ cord-009571-mygj2nd4 2136 13 obesity obesity NN cord-009571-mygj2nd4 2136 14 were be VBD cord-009571-mygj2nd4 2136 15 reviewed review VBN cord-009571-mygj2nd4 2136 16 for for IN cord-009571-mygj2nd4 2136 17 evidence evidence NN cord-009571-mygj2nd4 2136 18 of of IN cord-009571-mygj2nd4 2136 19 connective connective JJ cord-009571-mygj2nd4 2136 20 tissue tissue NN cord-009571-mygj2nd4 2136 21 disease disease NN cord-009571-mygj2nd4 2136 22 and and CC cord-009571-mygj2nd4 2136 23 immunologic immunologic JJ cord-009571-mygj2nd4 2136 24 abnormalities abnormality NNS cord-009571-mygj2nd4 2136 25 . . . cord-009571-mygj2nd4 2137 1 Presence presence NN cord-009571-mygj2nd4 2137 2 of of IN cord-009571-mygj2nd4 2137 3 arthritis arthritis NN cord-009571-mygj2nd4 2137 4 or or CC cord-009571-mygj2nd4 2137 5 arthralgias arthralgias JJ cord-009571-mygj2nd4 2137 6 and and CC cord-009571-mygj2nd4 2137 7 extraarticular extraarticular JJ cord-009571-mygj2nd4 2137 8 connective connective JJ cord-009571-mygj2nd4 2137 9 tissue tissue NN cord-009571-mygj2nd4 2137 10 symptoms symptom NNS cord-009571-mygj2nd4 2137 11 , , , cord-009571-mygj2nd4 2137 12 elevated elevate VBN cord-009571-mygj2nd4 2137 13 Westergren Westergren NNP cord-009571-mygj2nd4 2137 14 sedimentation sedimentation NN cord-009571-mygj2nd4 2137 15 rate rate NN cord-009571-mygj2nd4 2137 16 ( ( -LRB- cord-009571-mygj2nd4 2137 17 ESR ESR NNP cord-009571-mygj2nd4 2137 18 ) ) -RRB- cord-009571-mygj2nd4 2137 19 , , , cord-009571-mygj2nd4 2137 20 and and CC cord-009571-mygj2nd4 2137 21 absence absence NN cord-009571-mygj2nd4 2137 22 of of IN cord-009571-mygj2nd4 2137 23 other other JJ cord-009571-mygj2nd4 2137 24 significant significant JJ cord-009571-mygj2nd4 2137 25 forms form NNS cord-009571-mygj2nd4 2137 26 of of IN cord-009571-mygj2nd4 2137 27 arthritis arthritis NN cord-009571-mygj2nd4 2137 28 were be VBD cord-009571-mygj2nd4 2137 29 criteria criterion NNS cord-009571-mygj2nd4 2137 30 for for IN cord-009571-mygj2nd4 2137 31 diagnosis diagnosis NN cord-009571-mygj2nd4 2137 32 of of IN cord-009571-mygj2nd4 2137 33 postintestinal postintestinal JJ cord-009571-mygj2nd4 2137 34 bypass bypass NN cord-009571-mygj2nd4 2137 35 arthritis arthritis NN cord-009571-mygj2nd4 2137 36 . . . cord-009571-mygj2nd4 2138 1 Eleven eleven CD cord-009571-mygj2nd4 2138 2 of of IN cord-009571-mygj2nd4 2138 3 the the DT cord-009571-mygj2nd4 2138 4 19 19 CD cord-009571-mygj2nd4 2138 5 patients patient NNS cord-009571-mygj2nd4 2138 6 met meet VBD cord-009571-mygj2nd4 2138 7 these these DT cord-009571-mygj2nd4 2138 8 criteria criterion NNS cord-009571-mygj2nd4 2138 9 . . . cord-009571-mygj2nd4 2139 1 Seven seven CD cord-009571-mygj2nd4 2139 2 were be VBD cord-009571-mygj2nd4 2139 3 females female NNS cord-009571-mygj2nd4 2139 4 . . . cord-009571-mygj2nd4 2140 1 Six six CD cord-009571-mygj2nd4 2140 2 of of IN cord-009571-mygj2nd4 2140 3 the the DT cord-009571-mygj2nd4 2140 4 I i NN cord-009571-mygj2nd4 2140 5 1 1 CD cord-009571-mygj2nd4 2140 6 had have VBD cord-009571-mygj2nd4 2140 7 joint joint JJ cord-009571-mygj2nd4 2140 8 swelling swelling NN cord-009571-mygj2nd4 2140 9 and and CC cord-009571-mygj2nd4 2140 10 5 5 CD cord-009571-mygj2nd4 2140 11 had have VBD cord-009571-mygj2nd4 2140 12 only only RB cord-009571-mygj2nd4 2140 13 arthralgias arthralgias JJ cord-009571-mygj2nd4 2140 14 . . . cord-009571-mygj2nd4 2141 1 All all DT cord-009571-mygj2nd4 2141 2 had have VBD cord-009571-mygj2nd4 2141 3 moderately moderately RB cord-009571-mygj2nd4 2141 4 elevated elevate VBN cord-009571-mygj2nd4 2141 5 ESR ESR NNP cord-009571-mygj2nd4 2141 6 . . . cord-009571-mygj2nd4 2142 1 Extraarticular extraarticular JJ cord-009571-mygj2nd4 2142 2 manifestations manifestation NNS cord-009571-mygj2nd4 2142 3 include include VBP cord-009571-mygj2nd4 2142 4 erythema erythema NN cord-009571-mygj2nd4 2142 5 nodosum nodosum NN cord-009571-mygj2nd4 2142 6 ( ( -LRB- cord-009571-mygj2nd4 2142 7 3 3 CD cord-009571-mygj2nd4 2142 8 patients patient NNS cord-009571-mygj2nd4 2142 9 ) ) -RRB- cord-009571-mygj2nd4 2142 10 , , , cord-009571-mygj2nd4 2142 11 pleural pleural JJ cord-009571-mygj2nd4 2142 12 effusion effusion NN cord-009571-mygj2nd4 2142 13 ( ( -LRB- cord-009571-mygj2nd4 2142 14 2 2 CD cord-009571-mygj2nd4 2142 15 patients patient NNS cord-009571-mygj2nd4 2142 16 ) ) -RRB- cord-009571-mygj2nd4 2142 17 , , , cord-009571-mygj2nd4 2142 18 and and CC cord-009571-mygj2nd4 2142 19 carpal carpal NN cord-009571-mygj2nd4 2142 20 tunnel tunnel NN cord-009571-mygj2nd4 2142 21 syndrome syndrome NN cord-009571-mygj2nd4 2142 22 ( ( -LRB- cord-009571-mygj2nd4 2142 23 1 1 CD cord-009571-mygj2nd4 2142 24 patient patient NN cord-009571-mygj2nd4 2142 25 ) ) -RRB- cord-009571-mygj2nd4 2142 26 . . . cord-009571-mygj2nd4 2143 1 Synovial synovial JJ cord-009571-mygj2nd4 2143 2 fluid fluid JJ cord-009571-mygj2nd4 2143 3 analysis analysis NN cord-009571-mygj2nd4 2143 4 in in IN cord-009571-mygj2nd4 2143 5 5 5 CD cord-009571-mygj2nd4 2143 6 showed show VBD cord-009571-mygj2nd4 2143 7 mild mild JJ cord-009571-mygj2nd4 2143 8 to to IN cord-009571-mygj2nd4 2143 9 moderate moderate JJ cord-009571-mygj2nd4 2143 10 inflammation inflammation NN cord-009571-mygj2nd4 2143 11 . . . cord-009571-mygj2nd4 2144 1 Serum serum NN cord-009571-mygj2nd4 2144 2 rheumatoid rheumatoid NN cord-009571-mygj2nd4 2144 3 factor factor NN cord-009571-mygj2nd4 2144 4 was be VBD cord-009571-mygj2nd4 2144 5 present present JJ cord-009571-mygj2nd4 2144 6 in in IN cord-009571-mygj2nd4 2144 7 1 1 CD cord-009571-mygj2nd4 2144 8 patient patient NN cord-009571-mygj2nd4 2144 9 in in IN cord-009571-mygj2nd4 2144 10 low low JJ cord-009571-mygj2nd4 2144 11 titer titer NN cord-009571-mygj2nd4 2144 12 while while IN cord-009571-mygj2nd4 2144 13 3 3 CD cord-009571-mygj2nd4 2144 14 patients patient NNS cord-009571-mygj2nd4 2144 15 had have VBD cord-009571-mygj2nd4 2144 16 positive positive JJ cord-009571-mygj2nd4 2144 17 ANA ANA NNP cord-009571-mygj2nd4 2144 18 in in IN cord-009571-mygj2nd4 2144 19 titers titer NNS cord-009571-mygj2nd4 2144 20 ranging range VBG cord-009571-mygj2nd4 2144 21 from from IN cord-009571-mygj2nd4 2144 22 1:128 1:128 CD cord-009571-mygj2nd4 2144 23 to to IN cord-009571-mygj2nd4 2144 24 1:1024 1:1024 CD cord-009571-mygj2nd4 2144 25 . . . cord-009571-mygj2nd4 2145 1 In in IN cord-009571-mygj2nd4 2145 2 2 2 CD cord-009571-mygj2nd4 2145 3 patients patient NNS cord-009571-mygj2nd4 2145 4 the the DT cord-009571-mygj2nd4 2145 5 ANA ANA NNP cord-009571-mygj2nd4 2145 6 reverted revert VBD cord-009571-mygj2nd4 2145 7 to to IN cord-009571-mygj2nd4 2145 8 negative negative JJ cord-009571-mygj2nd4 2145 9 with with IN cord-009571-mygj2nd4 2145 10 therapy therapy NN cord-009571-mygj2nd4 2145 11 , , , cord-009571-mygj2nd4 2145 12 and and CC cord-009571-mygj2nd4 2145 13 in in IN cord-009571-mygj2nd4 2145 14 the the DT cord-009571-mygj2nd4 2145 15 third third JJ cord-009571-mygj2nd4 2145 16 patient patient NN cord-009571-mygj2nd4 2145 17 the the DT cord-009571-mygj2nd4 2145 18 ANA ANA NNP cord-009571-mygj2nd4 2145 19 became become VBD cord-009571-mygj2nd4 2145 20 negative negative JJ cord-009571-mygj2nd4 2145 21 after after IN cord-009571-mygj2nd4 2145 22 the the DT cord-009571-mygj2nd4 2145 23 bypass bypass NN cord-009571-mygj2nd4 2145 24 was be VBD cord-009571-mygj2nd4 2145 25 reversed reverse VBN cord-009571-mygj2nd4 2145 26 . . . cord-009571-mygj2nd4 2146 1 Four four CD cord-009571-mygj2nd4 2146 2 had have VBD cord-009571-mygj2nd4 2146 3 hypercomplementemia hypercomplementemia NN cord-009571-mygj2nd4 2146 4 , , , cord-009571-mygj2nd4 2146 5 6 6 CD cord-009571-mygj2nd4 2146 6 had have VBD cord-009571-mygj2nd4 2146 7 elevated elevate VBN cord-009571-mygj2nd4 2146 8 serum serum NN cord-009571-mygj2nd4 2146 9 IgG igg NN cord-009571-mygj2nd4 2146 10 , , , cord-009571-mygj2nd4 2146 11 and and CC cord-009571-mygj2nd4 2146 12 3 3 CD cord-009571-mygj2nd4 2146 13 had have VBD cord-009571-mygj2nd4 2146 14 ele ele JJ cord-009571-mygj2nd4 2146 15 - - HYPH cord-009571-mygj2nd4 2146 16 vated vated JJ cord-009571-mygj2nd4 2146 17 serum serum NN cord-009571-mygj2nd4 2147 1 IgA. IgA. NNP cord-009571-mygj2nd4 2147 2 None none NN cord-009571-mygj2nd4 2147 3 of of IN cord-009571-mygj2nd4 2147 4 the the DT cord-009571-mygj2nd4 2147 5 1 1 CD cord-009571-mygj2nd4 2147 6 1 1 CD cord-009571-mygj2nd4 2147 7 patients patient NNS cord-009571-mygj2nd4 2147 8 demonstrated demonstrate VBD cord-009571-mygj2nd4 2147 9 cryoglobulins cryoglobulin NNS cord-009571-mygj2nd4 2147 10 , , , cord-009571-mygj2nd4 2147 11 but but CC cord-009571-mygj2nd4 2147 12 1 1 CD cord-009571-mygj2nd4 2147 13 had have VBD cord-009571-mygj2nd4 2147 14 soluble soluble JJ cord-009571-mygj2nd4 2147 15 immune immune JJ cord-009571-mygj2nd4 2147 16 complexes complex NNS cord-009571-mygj2nd4 2147 17 by by IN cord-009571-mygj2nd4 2147 18 complement complement JJ cord-009571-mygj2nd4 2147 19 inhibition inhibition NN cord-009571-mygj2nd4 2147 20 technique technique NN cord-009571-mygj2nd4 2147 21 . . . cord-009571-mygj2nd4 2148 1 Synovial synovial JJ cord-009571-mygj2nd4 2148 2 biopsy biopsy NN cord-009571-mygj2nd4 2148 3 in in IN cord-009571-mygj2nd4 2148 4 1 1 CD cord-009571-mygj2nd4 2148 5 case case NN cord-009571-mygj2nd4 2148 6 showed show VBD cord-009571-mygj2nd4 2148 7 chronic chronic JJ cord-009571-mygj2nd4 2148 8 inflammation inflammation NN cord-009571-mygj2nd4 2148 9 and and CC cord-009571-mygj2nd4 2148 10 IgA IgA NNP cord-009571-mygj2nd4 2148 11 and and CC cord-009571-mygj2nd4 2148 12 C C NNP cord-009571-mygj2nd4 2148 13 ' ' POS cord-009571-mygj2nd4 2148 14 deposition deposition NN cord-009571-mygj2nd4 2148 15 by by IN cord-009571-mygj2nd4 2148 16 immunofluorescence immunofluorescence NN cord-009571-mygj2nd4 2148 17 . . . cord-009571-mygj2nd4 2149 1 HLA HLA NNP cord-009571-mygj2nd4 2149 2 typing type VBG cord-009571-mygj2nd4 2149 3 of of IN cord-009571-mygj2nd4 2149 4 6 6 CD cord-009571-mygj2nd4 2149 5 of of IN cord-009571-mygj2nd4 2149 6 the the DT cord-009571-mygj2nd4 2149 7 1 1 CD cord-009571-mygj2nd4 2149 8 1 1 CD cord-009571-mygj2nd4 2149 9 patients patient NNS cord-009571-mygj2nd4 2149 10 with with IN cord-009571-mygj2nd4 2149 11 post post JJ cord-009571-mygj2nd4 2149 12 bypass bypass NN cord-009571-mygj2nd4 2149 13 arthritis arthritis NN cord-009571-mygj2nd4 2149 14 showed show VBD cord-009571-mygj2nd4 2149 15 no no DT cord-009571-mygj2nd4 2149 16 trend trend NN cord-009571-mygj2nd4 2149 17 . . . cord-009571-mygj2nd4 2150 1 In in IN cord-009571-mygj2nd4 2150 2 I -PRON- PRP cord-009571-mygj2nd4 2150 3 patient patient VBP cord-009571-mygj2nd4 2150 4 the the DT cord-009571-mygj2nd4 2150 5 length length NN cord-009571-mygj2nd4 2150 6 of of IN cord-009571-mygj2nd4 2150 7 bypassed bypass VBN cord-009571-mygj2nd4 2150 8 bowel bowel NN cord-009571-mygj2nd4 2150 9 was be VBD cord-009571-mygj2nd4 2150 10 reduced reduce VBN cord-009571-mygj2nd4 2150 11 , , , cord-009571-mygj2nd4 2150 12 and and CC cord-009571-mygj2nd4 2150 13 in in IN cord-009571-mygj2nd4 2150 14 another another DT cord-009571-mygj2nd4 2150 15 the the DT cord-009571-mygj2nd4 2150 16 bypass bypass NN cord-009571-mygj2nd4 2150 17 was be VBD cord-009571-mygj2nd4 2150 18 reversed reverse VBN cord-009571-mygj2nd4 2150 19 . . . cord-009571-mygj2nd4 2151 1 In in IN cord-009571-mygj2nd4 2151 2 both both DT cord-009571-mygj2nd4 2151 3 cases case NNS cord-009571-mygj2nd4 2151 4 the the DT cord-009571-mygj2nd4 2151 5 arthritis arthritis NN cord-009571-mygj2nd4 2151 6 remitted remit VBN cord-009571-mygj2nd4 2151 7 . . . cord-009571-mygj2nd4 2152 1 Two two CD cord-009571-mygj2nd4 2152 2 patients patient NNS cord-009571-mygj2nd4 2152 3 required require VBD cord-009571-mygj2nd4 2152 4 low low JJ cord-009571-mygj2nd4 2152 5 dose dose NN cord-009571-mygj2nd4 2152 6 prednisone prednisone JJ cord-009571-mygj2nd4 2152 7 therapy therapy NN cord-009571-mygj2nd4 2152 8 for for IN cord-009571-mygj2nd4 2152 9 the the DT cord-009571-mygj2nd4 2152 10 arthritis arthritis NN cord-009571-mygj2nd4 2152 11 ; ; : cord-009571-mygj2nd4 2152 12 the the DT cord-009571-mygj2nd4 2152 13 others other NNS cord-009571-mygj2nd4 2152 14 were be VBD cord-009571-mygj2nd4 2152 15 treated treat VBN cord-009571-mygj2nd4 2152 16 effectively effectively RB cord-009571-mygj2nd4 2152 17 with with IN cord-009571-mygj2nd4 2152 18 nonsteroidal nonsteroidal JJ cord-009571-mygj2nd4 2152 19 antiinflammatory antiinflammatory JJ cord-009571-mygj2nd4 2152 20 agents agent NNS cord-009571-mygj2nd4 2152 21 . . . cord-009571-mygj2nd4 2153 1 These these DT cord-009571-mygj2nd4 2153 2 1 1 CD cord-009571-mygj2nd4 2153 3 1 1 CD cord-009571-mygj2nd4 2153 4 patients patient NNS cord-009571-mygj2nd4 2153 5 had have VBD cord-009571-mygj2nd4 2153 6 an an DT cord-009571-mygj2nd4 2153 7 inflammatory inflammatory JJ cord-009571-mygj2nd4 2153 8 arthropathy arthropathy NN cord-009571-mygj2nd4 2153 9 often often RB cord-009571-mygj2nd4 2153 10 accompanied accompany VBN cord-009571-mygj2nd4 2153 11 by by IN cord-009571-mygj2nd4 2153 12 features feature NNS cord-009571-mygj2nd4 2153 13 suggestive suggestive JJ cord-009571-mygj2nd4 2153 14 of of IN cord-009571-mygj2nd4 2153 15 connective connective JJ cord-009571-mygj2nd4 2153 16 tissue tissue NN cord-009571-mygj2nd4 2153 17 disease disease NN cord-009571-mygj2nd4 2153 18 , , , cord-009571-mygj2nd4 2153 19 such such JJ cord-009571-mygj2nd4 2153 20 as as IN cord-009571-mygj2nd4 2153 21 erythema erythema NN cord-009571-mygj2nd4 2153 22 nodosum nodosum NNP cord-009571-mygj2nd4 2153 23 , , , cord-009571-mygj2nd4 2153 24 pleural pleural JJ cord-009571-mygj2nd4 2153 25 effusions effusion NNS cord-009571-mygj2nd4 2153 26 , , , cord-009571-mygj2nd4 2153 27 and and CC cord-009571-mygj2nd4 2153 28 circulating circulate VBG cord-009571-mygj2nd4 2153 29 ANA ANA NNP cord-009571-mygj2nd4 2153 30 . . . cord-009571-mygj2nd4 2154 1 Although although IN cord-009571-mygj2nd4 2154 2 none none NN cord-009571-mygj2nd4 2154 3 had have VBD cord-009571-mygj2nd4 2154 4 cryoglobulins cryoglobulin NNS cord-009571-mygj2nd4 2154 5 , , , cord-009571-mygj2nd4 2154 6 which which WDT cord-009571-mygj2nd4 2154 7 were be VBD cord-009571-mygj2nd4 2154 8 previously previously RB cord-009571-mygj2nd4 2154 9 reported report VBN cord-009571-mygj2nd4 2154 10 by by IN cord-009571-mygj2nd4 2154 11 others other NNS cord-009571-mygj2nd4 2154 12 , , , cord-009571-mygj2nd4 2154 13 1 1 CD cord-009571-mygj2nd4 2154 14 had have VBD cord-009571-mygj2nd4 2154 15 circulating circulate VBG cord-009571-mygj2nd4 2154 16 immune immune JJ cord-009571-mygj2nd4 2154 17 complex complex NN cord-009571-mygj2nd4 2154 18 . . . cord-009571-mygj2nd4 2155 1 This this DT cord-009571-mygj2nd4 2155 2 suggests suggest VBZ cord-009571-mygj2nd4 2155 3 that that IN cord-009571-mygj2nd4 2155 4 immune immune JJ cord-009571-mygj2nd4 2155 5 mechanisms mechanism NNS cord-009571-mygj2nd4 2155 6 are be VBP cord-009571-mygj2nd4 2155 7 involved involve VBN cord-009571-mygj2nd4 2155 8 in in IN cord-009571-mygj2nd4 2155 9 the the DT cord-009571-mygj2nd4 2155 10 pathogenesis pathogenesis NN cord-009571-mygj2nd4 2155 11 of of IN cord-009571-mygj2nd4 2155 12 arthritis arthritis NN cord-009571-mygj2nd4 2155 13 in in IN cord-009571-mygj2nd4 2155 14 some some DT cord-009571-mygj2nd4 2155 15 , , , cord-009571-mygj2nd4 2155 16 if if IN cord-009571-mygj2nd4 2155 17 not not RB cord-009571-mygj2nd4 2155 18 all all DT cord-009571-mygj2nd4 2155 19 , , , cord-009571-mygj2nd4 2155 20 of of IN cord-009571-mygj2nd4 2155 21 these these DT cord-009571-mygj2nd4 2155 22 patients patient NNS cord-009571-mygj2nd4 2155 23 . . . cord-009571-mygj2nd4 2156 1 Honig Honig NNP cord-009571-mygj2nd4 2156 2 et et NNP cord-009571-mygj2nd4 2156 3 a1 a1 NN cord-009571-mygj2nd4 2156 4 ( ( -LRB- cord-009571-mygj2nd4 2156 5 Arthritis Arthritis NNP cord-009571-mygj2nd4 2156 6 and and CC cord-009571-mygj2nd4 2156 7 Rheum Rheum NNP cord-009571-mygj2nd4 2156 8 201065 201065 CD cord-009571-mygj2nd4 2156 9 , , , cord-009571-mygj2nd4 2156 10 1977 1977 CD cord-009571-mygj2nd4 2156 11 recently recently RB cord-009571-mygj2nd4 2156 12 reported report VBD cord-009571-mygj2nd4 2156 13 that that IN cord-009571-mygj2nd4 2156 14 patients patient NNS cord-009571-mygj2nd4 2156 15 with with IN cord-009571-mygj2nd4 2156 16 active active JJ cord-009571-mygj2nd4 2156 17 systemic systemic JJ cord-009571-mygj2nd4 2156 18 lupus lupus NN cord-009571-mygj2nd4 2156 19 erythematosus erythematosus NN cord-009571-mygj2nd4 2156 20 ( ( -LRB- cord-009571-mygj2nd4 2156 21 SLE SLE NNP cord-009571-mygj2nd4 2156 22 ) ) -RRB- cord-009571-mygj2nd4 2156 23 usually usually RB cord-009571-mygj2nd4 2156 24 do do VBP cord-009571-mygj2nd4 2156 25 not not RB cord-009571-mygj2nd4 2156 26 have have VB cord-009571-mygj2nd4 2156 27 markedly markedly RB cord-009571-mygj2nd4 2156 28 increased increase VBN cord-009571-mygj2nd4 2156 29 serum serum NN cord-009571-mygj2nd4 2156 30 concentrations concentration NNS cord-009571-mygj2nd4 2156 31 ( ( -LRB- cord-009571-mygj2nd4 2156 32 > > NFP cord-009571-mygj2nd4 2156 33 200 200 CD cord-009571-mygj2nd4 2156 34 pg pg NN cord-009571-mygj2nd4 2156 35 / / SYM cord-009571-mygj2nd4 2156 36 ml ml NNP cord-009571-mygj2nd4 2156 37 ) ) -RRB- cord-009571-mygj2nd4 2156 38 of of IN cord-009571-mygj2nd4 2156 39 C C NNP cord-009571-mygj2nd4 2156 40 - - HYPH cord-009571-mygj2nd4 2156 41 reactive reactive JJ cord-009571-mygj2nd4 2156 42 protein protein NN cord-009571-mygj2nd4 2156 43 ( ( -LRB- cord-009571-mygj2nd4 2156 44 CRP CRP NNP cord-009571-mygj2nd4 2156 45 ) ) -RRB- cord-009571-mygj2nd4 2156 46 and and CC cord-009571-mygj2nd4 2156 47 that that IN cord-009571-mygj2nd4 2156 48 such such PDT cord-009571-mygj2nd4 2156 49 a a DT cord-009571-mygj2nd4 2156 50 finding finding NN cord-009571-mygj2nd4 2156 51 suggests suggest VBZ cord-009571-mygj2nd4 2156 52 the the DT cord-009571-mygj2nd4 2156 53 presence presence NN cord-009571-mygj2nd4 2156 54 of of IN cord-009571-mygj2nd4 2156 55 superimposed superimpose VBN cord-009571-mygj2nd4 2156 56 infection infection NN cord-009571-mygj2nd4 2156 57 rather rather RB cord-009571-mygj2nd4 2156 58 than than IN cord-009571-mygj2nd4 2156 59 active active JJ cord-009571-mygj2nd4 2156 60 lupus lupus NN cord-009571-mygj2nd4 2156 61 . . . cord-009571-mygj2nd4 2157 1 Since since IN cord-009571-mygj2nd4 2157 2 a a DT cord-009571-mygj2nd4 2157 3 semi semi JJ cord-009571-mygj2nd4 2157 4 - - JJ cord-009571-mygj2nd4 2157 5 quantitative quantitative JJ cord-009571-mygj2nd4 2157 6 capillary capillary JJ cord-009571-mygj2nd4 2157 7 precipitin precipitin NN cord-009571-mygj2nd4 2157 8 technique technique NN cord-009571-mygj2nd4 2157 9 was be VBD cord-009571-mygj2nd4 2157 10 employed employ VBN cord-009571-mygj2nd4 2157 11 in in IN cord-009571-mygj2nd4 2157 12 that that DT cord-009571-mygj2nd4 2157 13 study study NN cord-009571-mygj2nd4 2157 14 , , , cord-009571-mygj2nd4 2157 15 in in IN cord-009571-mygj2nd4 2157 16 which which WDT cord-009571-mygj2nd4 2157 17 only only RB cord-009571-mygj2nd4 2157 18 very very RB cord-009571-mygj2nd4 2157 19 high high JJ cord-009571-mygj2nd4 2157 20 CRP CRP NNP cord-009571-mygj2nd4 2157 21 concentrations concentration NNS cord-009571-mygj2nd4 2157 22 were be VBD cord-009571-mygj2nd4 2157 23 regarded regard VBN cord-009571-mygj2nd4 2157 24 as as IN cord-009571-mygj2nd4 2157 25 positive positive JJ cord-009571-mygj2nd4 2157 26 , , , cord-009571-mygj2nd4 2157 27 we -PRON- PRP cord-009571-mygj2nd4 2157 28 investigated investigate VBD cord-009571-mygj2nd4 2157 29 the the DT cord-009571-mygj2nd4 2157 30 significance significance NN cord-009571-mygj2nd4 2157 31 of of IN cord-009571-mygj2nd4 2157 32 lesser less JJR cord-009571-mygj2nd4 2157 33 increases increase NNS cord-009571-mygj2nd4 2157 34 in in IN cord-009571-mygj2nd4 2157 35 serum serum NN cord-009571-mygj2nd4 2157 36 CRP crp NN cord-009571-mygj2nd4 2157 37 concentration concentration NN cord-009571-mygj2nd4 2157 38 in in IN cord-009571-mygj2nd4 2157 39 patients patient NNS cord-009571-mygj2nd4 2157 40 with with IN cord-009571-mygj2nd4 2157 41 SLE SLE NNP cord-009571-mygj2nd4 2157 42 , , , cord-009571-mygj2nd4 2157 43 using use VBG cord-009571-mygj2nd4 2157 44 a a DT cord-009571-mygj2nd4 2157 45 quantitative quantitative JJ cord-009571-mygj2nd4 2157 46 radial radial JJ cord-009571-mygj2nd4 2157 47 immunodiffusion immunodiffusion NN cord-009571-mygj2nd4 2157 48 method method NN cord-009571-mygj2nd4 2157 49 sensitive sensitive JJ cord-009571-mygj2nd4 2157 50 to to IN cord-009571-mygj2nd4 2157 51 1.5 1.5 CD cord-009571-mygj2nd4 2157 52 pg pg NN cord-009571-mygj2nd4 2157 53 / / SYM cord-009571-mygj2nd4 2157 54 ml ml NN cord-009571-mygj2nd4 2157 55 . . . cord-009571-mygj2nd4 2158 1 We -PRON- PRP cord-009571-mygj2nd4 2158 2 retrospectively retrospectively RB cord-009571-mygj2nd4 2158 3 determined determine VBD cord-009571-mygj2nd4 2158 4 CRP CRP NNP cord-009571-mygj2nd4 2158 5 concentrations concentration NNS cord-009571-mygj2nd4 2158 6 in in IN cord-009571-mygj2nd4 2158 7 141 141 CD cord-009571-mygj2nd4 2158 8 serum serum NN cord-009571-mygj2nd4 2158 9 samples sample NNS cord-009571-mygj2nd4 2158 10 collected collect VBN cord-009571-mygj2nd4 2158 11 from from IN cord-009571-mygj2nd4 2158 12 a a DT cord-009571-mygj2nd4 2158 13 group group NN cord-009571-mygj2nd4 2158 14 of of IN cord-009571-mygj2nd4 2158 15 17 17 CD cord-009571-mygj2nd4 2158 16 patients patient NNS cord-009571-mygj2nd4 2158 17 with with IN cord-009571-mygj2nd4 2158 18 SLE SLE NNP cord-009571-mygj2nd4 2158 19 over over IN cord-009571-mygj2nd4 2158 20 a a DT cord-009571-mygj2nd4 2158 21 mean mean JJ cord-009571-mygj2nd4 2158 22 period period NN cord-009571-mygj2nd4 2158 23 of of IN cord-009571-mygj2nd4 2158 24 19 19 CD cord-009571-mygj2nd4 2158 25 months month NNS cord-009571-mygj2nd4 2158 26 . . . cord-009571-mygj2nd4 2159 1 Thirtytwo thirtytwo NN cord-009571-mygj2nd4 2159 2 episodes episode NNS cord-009571-mygj2nd4 2159 3 of of IN cord-009571-mygj2nd4 2159 4 significant significant JJ cord-009571-mygj2nd4 2159 5 increase increase NN cord-009571-mygj2nd4 2159 6 in in IN cord-009571-mygj2nd4 2159 7 serum serum NN cord-009571-mygj2nd4 2159 8 CRP crp NN cord-009571-mygj2nd4 2159 9 concentration concentration NN cord-009571-mygj2nd4 2159 10 were be VBD cord-009571-mygj2nd4 2159 11 detected detect VBN cord-009571-mygj2nd4 2159 12 . . . cord-009571-mygj2nd4 2160 1 Careful careful JJ cord-009571-mygj2nd4 2160 2 review review NN cord-009571-mygj2nd4 2160 3 of of IN cord-009571-mygj2nd4 2160 4 clinical clinical JJ cord-009571-mygj2nd4 2160 5 findings finding NNS cord-009571-mygj2nd4 2160 6 associated associate VBN cord-009571-mygj2nd4 2160 7 with with IN cord-009571-mygj2nd4 2160 8 each each DT cord-009571-mygj2nd4 2160 9 CRP CRP NNP cord-009571-mygj2nd4 2160 10 peak peak NN cord-009571-mygj2nd4 2160 11 revealed reveal VBD cord-009571-mygj2nd4 2160 12 that that IN cord-009571-mygj2nd4 2160 13 these these DT cord-009571-mygj2nd4 2160 14 episodes episode NNS cord-009571-mygj2nd4 2160 15 were be VBD cord-009571-mygj2nd4 2160 16 associated associate VBN cord-009571-mygj2nd4 2160 17 with with IN cord-009571-mygj2nd4 2160 18 active active JJ cord-009571-mygj2nd4 2160 19 lupus lupus NN cord-009571-mygj2nd4 2160 20 without without IN cord-009571-mygj2nd4 2160 21 infection infection NN cord-009571-mygj2nd4 2160 22 in in IN cord-009571-mygj2nd4 2160 23 20 20 CD cord-009571-mygj2nd4 2160 24 instances instance NNS cord-009571-mygj2nd4 2160 25 ( ( -LRB- cord-009571-mygj2nd4 2160 26 median median JJ cord-009571-mygj2nd4 2160 27 CRP CRP NNP cord-009571-mygj2nd4 2160 28 concentration concentration NN cord-009571-mygj2nd4 2160 29 21 21 CD cord-009571-mygj2nd4 2160 30 pg pg NN cord-009571-mygj2nd4 2160 31 / / SYM cord-009571-mygj2nd4 2160 32 ml ml NNS cord-009571-mygj2nd4 2160 33 , , , cord-009571-mygj2nd4 2160 34 mean mean JJ cord-009571-mygj2nd4 2160 35 43.7 43.7 CD cord-009571-mygj2nd4 2160 36 , , , cord-009571-mygj2nd4 2160 37 range range VBP cord-009571-mygj2nd4 2160 38 7.8 7.8 CD cord-009571-mygj2nd4 2160 39 - - HYPH cord-009571-mygj2nd4 2160 40 197.2 197.2 CD cord-009571-mygj2nd4 2160 41 ) ) -RRB- cord-009571-mygj2nd4 2161 1 In in IN cord-009571-mygj2nd4 2161 2 9 9 CD cord-009571-mygj2nd4 2161 3 instances instance NNS cord-009571-mygj2nd4 2161 4 , , , cord-009571-mygj2nd4 2161 5 elevations elevation NNS cord-009571-mygj2nd4 2161 6 of of IN cord-009571-mygj2nd4 2161 7 serum serum NN cord-009571-mygj2nd4 2161 8 CRP crp NN cord-009571-mygj2nd4 2161 9 concentration concentration NN cord-009571-mygj2nd4 2161 10 were be VBD cord-009571-mygj2nd4 2161 11 attributed attribute VBN cord-009571-mygj2nd4 2161 12 to to IN cord-009571-mygj2nd4 2161 13 proven prove VBN cord-009571-mygj2nd4 2161 14 or or CC cord-009571-mygj2nd4 2161 15 suspected suspect VBN cord-009571-mygj2nd4 2161 16 superimposed superimpose VBN cord-009571-mygj2nd4 2161 17 infection infection NN cord-009571-mygj2nd4 2161 18 or or CC cord-009571-mygj2nd4 2161 19 bone bone NN cord-009571-mygj2nd4 2161 20 fracture fracture NN cord-009571-mygj2nd4 2161 21 ( ( -LRB- cord-009571-mygj2nd4 2161 22 median median NN cord-009571-mygj2nd4 2161 23 45 45 CD cord-009571-mygj2nd4 2161 24 pg pg NN cord-009571-mygj2nd4 2161 25 / / SYM cord-009571-mygj2nd4 2161 26 ml ml NNS cord-009571-mygj2nd4 2161 27 , , , cord-009571-mygj2nd4 2161 28 mean mean JJ cord-009571-mygj2nd4 2161 29 52.6 52.6 CD cord-009571-mygj2nd4 2161 30 , , , cord-009571-mygj2nd4 2161 31 range range NN cord-009571-mygj2nd4 2161 32 16.3 16.3 CD cord-009571-mygj2nd4 2161 33 - - HYPH cord-009571-mygj2nd4 2161 34 118.2 118.2 CD cord-009571-mygj2nd4 2161 35 ) ) -RRB- cord-009571-mygj2nd4 2161 36 . . . cord-009571-mygj2nd4 2162 1 Three three CD cord-009571-mygj2nd4 2162 2 CRP CRP NNP cord-009571-mygj2nd4 2162 3 elevations elevation NNS cord-009571-mygj2nd4 2162 4 of of IN cord-009571-mygj2nd4 2162 5 7.3 7.3 CD cord-009571-mygj2nd4 2162 6 , , , cord-009571-mygj2nd4 2162 7 8.2 8.2 CD cord-009571-mygj2nd4 2162 8 and and CC cord-009571-mygj2nd4 2162 9 39.4 39.4 CD cord-009571-mygj2nd4 2162 10 pg pg NNP cord-009571-mygj2nd4 2162 11 / / SYM cord-009571-mygj2nd4 2162 12 ml ml NNS cord-009571-mygj2nd4 2162 13 occurred occur VBD cord-009571-mygj2nd4 2162 14 at at IN cord-009571-mygj2nd4 2162 15 a a DT cord-009571-mygj2nd4 2162 16 time time NN cord-009571-mygj2nd4 2162 17 when when WRB cord-009571-mygj2nd4 2162 18 there there EX cord-009571-mygj2nd4 2162 19 was be VBD cord-009571-mygj2nd4 2162 20 clinical clinical JJ cord-009571-mygj2nd4 2162 21 evidence evidence NN cord-009571-mygj2nd4 2162 22 of of IN cord-009571-mygj2nd4 2162 23 neither neither DT cord-009571-mygj2nd4 2162 24 lupus lupus NN cord-009571-mygj2nd4 2162 25 activation activation NN cord-009571-mygj2nd4 2162 26 nor nor CC cord-009571-mygj2nd4 2162 27 infection infection NN cord-009571-mygj2nd4 2162 28 . . . cord-009571-mygj2nd4 2163 1 There there EX cord-009571-mygj2nd4 2163 2 were be VBD cord-009571-mygj2nd4 2163 3 8 8 CD cord-009571-mygj2nd4 2163 4 instances instance NNS cord-009571-mygj2nd4 2163 5 of of IN cord-009571-mygj2nd4 2163 6 onset onset NN cord-009571-mygj2nd4 2163 7 or or CC cord-009571-mygj2nd4 2163 8 exacerbation exacerbation NN cord-009571-mygj2nd4 2163 9 of of IN cord-009571-mygj2nd4 2163 10 lupus lupus NN cord-009571-mygj2nd4 2163 11 activity activity NN cord-009571-mygj2nd4 2163 12 at at IN cord-009571-mygj2nd4 2163 13 times time NNS cord-009571-mygj2nd4 2163 14 when when WRB cord-009571-mygj2nd4 2163 15 serum serum NN cord-009571-mygj2nd4 2163 16 samples sample NNS cord-009571-mygj2nd4 2163 17 did do VBD cord-009571-mygj2nd4 2163 18 not not RB cord-009571-mygj2nd4 2163 19 show show VB cord-009571-mygj2nd4 2163 20 elevated elevate VBN cord-009571-mygj2nd4 2163 21 CRP crp NN cord-009571-mygj2nd4 2163 22 levels level NNS cord-009571-mygj2nd4 2163 23 . . . cord-009571-mygj2nd4 2164 1 In in IN cord-009571-mygj2nd4 2164 2 2 2 CD cord-009571-mygj2nd4 2164 3 of of IN cord-009571-mygj2nd4 2164 4 these these DT cord-009571-mygj2nd4 2164 5 , , , cord-009571-mygj2nd4 2164 6 very very RB cord-009571-mygj2nd4 2164 7 active active JJ cord-009571-mygj2nd4 2164 8 disease disease NN cord-009571-mygj2nd4 2164 9 was be VBD cord-009571-mygj2nd4 2164 10 present present JJ cord-009571-mygj2nd4 2164 11 ; ; : cord-009571-mygj2nd4 2164 12 CRP CRP NNP cord-009571-mygj2nd4 2164 13 elevations elevation NNS cord-009571-mygj2nd4 2164 14 were be VBD cord-009571-mygj2nd4 2164 15 noted note VBN cord-009571-mygj2nd4 2164 16 in in IN cord-009571-mygj2nd4 2164 17 the the DT cord-009571-mygj2nd4 2164 18 next next JJ cord-009571-mygj2nd4 2164 19 samples sample NNS cord-009571-mygj2nd4 2164 20 obtained obtain VBN cord-009571-mygj2nd4 2164 21 , , , cord-009571-mygj2nd4 2164 22 13 13 CD cord-009571-mygj2nd4 2164 23 and and CC cord-009571-mygj2nd4 2164 24 33 33 CD cord-009571-mygj2nd4 2164 25 days day NNS cord-009571-mygj2nd4 2164 26 later later RB cord-009571-mygj2nd4 2164 27 . . . cord-009571-mygj2nd4 2165 1 In in IN cord-009571-mygj2nd4 2165 2 a a DT cord-009571-mygj2nd4 2165 3 third third JJ cord-009571-mygj2nd4 2165 4 patient patient NN cord-009571-mygj2nd4 2165 5 with with IN cord-009571-mygj2nd4 2165 6 both both DT cord-009571-mygj2nd4 2165 7 infection infection NN cord-009571-mygj2nd4 2165 8 and and CC cord-009571-mygj2nd4 2165 9 lupus lupus NN cord-009571-mygj2nd4 2165 10 activity activity NN cord-009571-mygj2nd4 2165 11 , , , cord-009571-mygj2nd4 2165 12 CRP CRP NNP cord-009571-mygj2nd4 2165 13 levels level NNS cord-009571-mygj2nd4 2165 14 were be VBD cord-009571-mygj2nd4 2165 15 found find VBN cord-009571-mygj2nd4 2165 16 elevated elevate VBN cord-009571-mygj2nd4 2165 17 8 8 CD cord-009571-mygj2nd4 2165 18 days day NNS cord-009571-mygj2nd4 2165 19 later later RB cord-009571-mygj2nd4 2165 20 . . . cord-009571-mygj2nd4 2166 1 These these DT cord-009571-mygj2nd4 2166 2 data datum NNS cord-009571-mygj2nd4 2166 3 indicate indicate VBP cord-009571-mygj2nd4 2166 4 that that IN cord-009571-mygj2nd4 2166 5 moderate moderate JJ cord-009571-mygj2nd4 2166 6 to to IN cord-009571-mygj2nd4 2166 7 marked marked JJ cord-009571-mygj2nd4 2166 8 increases increase NNS cord-009571-mygj2nd4 2166 9 in in IN cord-009571-mygj2nd4 2166 10 serum serum NN cord-009571-mygj2nd4 2166 11 CRP crp NN cord-009571-mygj2nd4 2166 12 concentration concentration NN cord-009571-mygj2nd4 2166 13 may may MD cord-009571-mygj2nd4 2166 14 occur occur VB cord-009571-mygj2nd4 2166 15 in in IN cord-009571-mygj2nd4 2166 16 the the DT cord-009571-mygj2nd4 2166 17 course course NN cord-009571-mygj2nd4 2166 18 of of IN cord-009571-mygj2nd4 2166 19 SLE SLE NNP cord-009571-mygj2nd4 2166 20 in in IN cord-009571-mygj2nd4 2166 21 association association NN cord-009571-mygj2nd4 2166 22 with with IN cord-009571-mygj2nd4 2166 23 activation activation NN cord-009571-mygj2nd4 2166 24 of of IN cord-009571-mygj2nd4 2166 25 disease disease NN cord-009571-mygj2nd4 2166 26 , , , cord-009571-mygj2nd4 2166 27 as as RB cord-009571-mygj2nd4 2166 28 well well RB cord-009571-mygj2nd4 2166 29 as as IN cord-009571-mygj2nd4 2166 30 in in IN cord-009571-mygj2nd4 2166 31 association association NN cord-009571-mygj2nd4 2166 32 with with IN cord-009571-mygj2nd4 2166 33 infection infection NN cord-009571-mygj2nd4 2166 34 or or CC cord-009571-mygj2nd4 2166 35 other other JJ cord-009571-mygj2nd4 2166 36 cause cause NN cord-009571-mygj2nd4 2166 37 of of IN cord-009571-mygj2nd4 2166 38 tissue tissue NN cord-009571-mygj2nd4 2166 39 necrosis necrosis NN cord-009571-mygj2nd4 2166 40 . . . cord-009571-mygj2nd4 2167 1 Rarely rarely RB cord-009571-mygj2nd4 2167 2 no no DT cord-009571-mygj2nd4 2167 3 obvious obvious JJ cord-009571-mygj2nd4 2167 4 clinical clinical JJ cord-009571-mygj2nd4 2167 5 cause cause NN cord-009571-mygj2nd4 2167 6 can can MD cord-009571-mygj2nd4 2167 7 be be VB cord-009571-mygj2nd4 2167 8 found find VBN cord-009571-mygj2nd4 2167 9 . . . cord-009571-mygj2nd4 2168 1 Occurrence occurrence NN cord-009571-mygj2nd4 2168 2 of of IN cord-009571-mygj2nd4 2168 3 serum serum NN cord-009571-mygj2nd4 2168 4 CRP crp NN cord-009571-mygj2nd4 2168 5 elevation elevation NN cord-009571-mygj2nd4 2168 6 in in IN cord-009571-mygj2nd4 2168 7 patients patient NNS cord-009571-mygj2nd4 2168 8 with with IN cord-009571-mygj2nd4 2168 9 SLE SLE NNP cord-009571-mygj2nd4 2168 10 does do VBZ cord-009571-mygj2nd4 2168 11 not not RB cord-009571-mygj2nd4 2168 12 differentiate differentiate VB cord-009571-mygj2nd4 2168 13 between between IN cord-009571-mygj2nd4 2168 14 lupus lupus NN cord-009571-mygj2nd4 2168 15 activity activity NN cord-009571-mygj2nd4 2168 16 and and CC cord-009571-mygj2nd4 2168 17 infection infection NN cord-009571-mygj2nd4 2168 18 . . . cord-009571-mygj2nd4 2169 1 and and CC cord-009571-mygj2nd4 2169 2 Immunologic Immunologic NNP cord-009571-mygj2nd4 2169 3 Study Study NNP cord-009571-mygj2nd4 2169 4 of of IN cord-009571-mygj2nd4 2169 5 the the DT cord-009571-mygj2nd4 2169 6 Post Post NNP cord-009571-mygj2nd4 2169 7 - - JJ cord-009571-mygj2nd4 2169 8 Intestinal intestinal JJ cord-009571-mygj2nd4 2169 9 Bypass Bypass NNP cord-009571-mygj2nd4 2169 10 Arthritis arthritis NN cord-009571-mygj2nd4 2169 11 - - HYPH cord-009571-mygj2nd4 2169 12 Dermatitis Dermatitis NNP cord-009571-mygj2nd4 2169 13 Syndrome Syndrome NNP cord-009571-mygj2nd4 2169 14 Medical Medical NNP cord-009571-mygj2nd4 2169 15 Versus Versus NNP cord-009571-mygj2nd4 2169 16 Surgical Surgical NNP cord-009571-mygj2nd4 2169 17 Management Management NNP cord-009571-mygj2nd4 2169 18 of of IN cord-009571-mygj2nd4 2169 19 Ischemic Ischemic NNP cord-009571-mygj2nd4 2169 20 Necrosis Necrosis NNP cord-009571-mygj2nd4 2169 21 of of IN cord-009571-mygj2nd4 2169 22 Bone Bone NNP cord-009571-mygj2nd4 2169 23 in in IN cord-009571-mygj2nd4 2169 24 Systemic Systemic NNP cord-009571-mygj2nd4 2169 25 Lupus Lupus NNP cord-009571-mygj2nd4 2169 26 Intestinal intestinal JJ cord-009571-mygj2nd4 2169 27 bypass bypass NN cord-009571-mygj2nd4 2169 28 surgery surgery NN cord-009571-mygj2nd4 2169 29 has have VBZ cord-009571-mygj2nd4 2169 30 become become VBN cord-009571-mygj2nd4 2169 31 a a DT cord-009571-mygj2nd4 2169 32 successful successful JJ cord-009571-mygj2nd4 2169 33 means mean NNS cord-009571-mygj2nd4 2169 34 of of IN cord-009571-mygj2nd4 2169 35 effecting effect VBG cord-009571-mygj2nd4 2169 36 weight weight NN cord-009571-mygj2nd4 2169 37 reduction reduction NN cord-009571-mygj2nd4 2169 38 in in IN cord-009571-mygj2nd4 2169 39 morbid morbid JJ cord-009571-mygj2nd4 2169 40 obesity obesity NN cord-009571-mygj2nd4 2169 41 . . . cord-009571-mygj2nd4 2170 1 As as IN cord-009571-mygj2nd4 2170 2 a a DT cord-009571-mygj2nd4 2170 3 complication complication NN cord-009571-mygj2nd4 2170 4 of of IN cord-009571-mygj2nd4 2170 5 surgery surgery NN cord-009571-mygj2nd4 2170 6 , , , cord-009571-mygj2nd4 2170 7 a a DT cord-009571-mygj2nd4 2170 8 fraction fraction NN cord-009571-mygj2nd4 2170 9 of of IN cord-009571-mygj2nd4 2170 10 patients patient NNS cord-009571-mygj2nd4 2170 11 develop develop VBP cord-009571-mygj2nd4 2170 12 an an DT cord-009571-mygj2nd4 2170 13 arthritis arthritis NN cord-009571-mygj2nd4 2170 14 and and CC cord-009571-mygj2nd4 2170 15 tenosynovitis tenosynovitis NN cord-009571-mygj2nd4 2170 16 which which WDT cord-009571-mygj2nd4 2170 17 may may MD cord-009571-mygj2nd4 2170 18 be be VB cord-009571-mygj2nd4 2170 19 associated associate VBN cord-009571-mygj2nd4 2170 20 with with IN cord-009571-mygj2nd4 2170 21 circulating circulate VBG cord-009571-mygj2nd4 2170 22 cryoproteins cryoprotein NNS cord-009571-mygj2nd4 2170 23 . . . cord-009571-mygj2nd4 2171 1 We -PRON- PRP cord-009571-mygj2nd4 2171 2 have have VBP cord-009571-mygj2nd4 2171 3 had have VBN cord-009571-mygj2nd4 2171 4 the the DT cord-009571-mygj2nd4 2171 5 opportunity opportunity NN cord-009571-mygj2nd4 2171 6 to to TO cord-009571-mygj2nd4 2171 7 study study VB cord-009571-mygj2nd4 2171 8 6 6 CD cord-009571-mygj2nd4 2171 9 patients patient NNS cord-009571-mygj2nd4 2171 10 with with IN cord-009571-mygj2nd4 2171 11 post post JJ cord-009571-mygj2nd4 2171 12 - - JJ cord-009571-mygj2nd4 2171 13 jejunoileostomy jejunoileostomy JJ cord-009571-mygj2nd4 2171 14 arthritis arthritis NN cord-009571-mygj2nd4 2171 15 , , , cord-009571-mygj2nd4 2171 16 all all DT cord-009571-mygj2nd4 2171 17 of of IN cord-009571-mygj2nd4 2171 18 whom whom WP cord-009571-mygj2nd4 2171 19 had have VBD cord-009571-mygj2nd4 2171 20 , , , cord-009571-mygj2nd4 2171 21 as as IN cord-009571-mygj2nd4 2171 22 a a DT cord-009571-mygj2nd4 2171 23 striking striking JJ cord-009571-mygj2nd4 2171 24 feature feature NN cord-009571-mygj2nd4 2171 25 of of IN cord-009571-mygj2nd4 2171 26 the the DT cord-009571-mygj2nd4 2171 27 illness illness NN cord-009571-mygj2nd4 2171 28 , , , cord-009571-mygj2nd4 2171 29 a a DT cord-009571-mygj2nd4 2171 30 widespread widespread JJ cord-009571-mygj2nd4 2171 31 dermatitis dermatitis NN cord-009571-mygj2nd4 2171 32 . . . cord-009571-mygj2nd4 2172 1 The the DT cord-009571-mygj2nd4 2172 2 patients patient NNS cord-009571-mygj2nd4 2172 3 were be VBD cord-009571-mygj2nd4 2172 4 all all RB cord-009571-mygj2nd4 2172 5 female female JJ cord-009571-mygj2nd4 2172 6 . . . cord-009571-mygj2nd4 2173 1 The the DT cord-009571-mygj2nd4 2173 2 arthritis arthritis NN cord-009571-mygj2nd4 2173 3 developed develop VBD cord-009571-mygj2nd4 2173 4 from from IN cord-009571-mygj2nd4 2173 5 12 12 CD cord-009571-mygj2nd4 2173 6 to to TO cord-009571-mygj2nd4 2173 7 62 62 CD cord-009571-mygj2nd4 2173 8 months month NNS cord-009571-mygj2nd4 2173 9 after after IN cord-009571-mygj2nd4 2173 10 surgery surgery NN cord-009571-mygj2nd4 2173 11 and and CC cord-009571-mygj2nd4 2173 12 predilected predilecte VBD cord-009571-mygj2nd4 2173 13 both both CC cord-009571-mygj2nd4 2173 14 large large JJ cord-009571-mygj2nd4 2173 15 and and CC cord-009571-mygj2nd4 2173 16 small small JJ cord-009571-mygj2nd4 2173 17 joints joint NNS cord-009571-mygj2nd4 2173 18 of of IN cord-009571-mygj2nd4 2173 19 the the DT cord-009571-mygj2nd4 2173 20 upper upper JJ cord-009571-mygj2nd4 2173 21 and and CC cord-009571-mygj2nd4 2173 22 lower low JJR cord-009571-mygj2nd4 2173 23 - - HYPH cord-009571-mygj2nd4 2173 24 extremities extremity NNS cord-009571-mygj2nd4 2173 25 . . . cord-009571-mygj2nd4 2174 1 Associated associate VBN cord-009571-mygj2nd4 2174 2 with with IN cord-009571-mygj2nd4 2174 3 the the DT cord-009571-mygj2nd4 2174 4 arthritis arthritis NN cord-009571-mygj2nd4 2174 5 were be VBD cord-009571-mygj2nd4 2174 6 erythematous erythematous JJ cord-009571-mygj2nd4 2174 7 macules macule NNS cord-009571-mygj2nd4 2174 8 , , , cord-009571-mygj2nd4 2174 9 ranging range VBG cord-009571-mygj2nd4 2174 10 in in IN cord-009571-mygj2nd4 2174 11 size size NN cord-009571-mygj2nd4 2174 12 from from IN cord-009571-mygj2nd4 2174 13 2 2 CD cord-009571-mygj2nd4 2174 14 to to TO cord-009571-mygj2nd4 2174 15 12 12 CD cord-009571-mygj2nd4 2174 16 mm mm NNS cord-009571-mygj2nd4 2174 17 in in IN cord-009571-mygj2nd4 2174 18 diameter diameter NN cord-009571-mygj2nd4 2174 19 . . . cord-009571-mygj2nd4 2175 1 These these DT cord-009571-mygj2nd4 2175 2 lesions lesion NNS cord-009571-mygj2nd4 2175 3 developed develop VBD cord-009571-mygj2nd4 2175 4 into into IN cord-009571-mygj2nd4 2175 5 papules papule NNS cord-009571-mygj2nd4 2175 6 over over IN cord-009571-mygj2nd4 2175 7 2 2 CD cord-009571-mygj2nd4 2175 8 days day NNS cord-009571-mygj2nd4 2175 9 , , , cord-009571-mygj2nd4 2175 10 subsequently subsequently RB cord-009571-mygj2nd4 2175 11 became become VBD cord-009571-mygj2nd4 2175 12 pustular pustular JJ cord-009571-mygj2nd4 2175 13 - - HYPH cord-009571-mygj2nd4 2175 14 vesicular vesicular JJ cord-009571-mygj2nd4 2175 15 , , , cord-009571-mygj2nd4 2175 16 and and CC cord-009571-mygj2nd4 2175 17 predilected predilected JJ cord-009571-mygj2nd4 2175 18 arms arm NNS cord-009571-mygj2nd4 2175 19 , , , cord-009571-mygj2nd4 2175 20 legs leg NNS cord-009571-mygj2nd4 2175 21 , , , cord-009571-mygj2nd4 2175 22 trunk trunk NN cord-009571-mygj2nd4 2175 23 , , , cord-009571-mygj2nd4 2175 24 and and CC cord-009571-mygj2nd4 2175 25 face face NN cord-009571-mygj2nd4 2175 26 . . . cord-009571-mygj2nd4 2176 1 Lesions lesion NNS cord-009571-mygj2nd4 2176 2 were be VBD cord-009571-mygj2nd4 2176 3 found find VBN cord-009571-mygj2nd4 2176 4 in in IN cord-009571-mygj2nd4 2176 5 different different JJ cord-009571-mygj2nd4 2176 6 stages stage NNS cord-009571-mygj2nd4 2176 7 of of IN cord-009571-mygj2nd4 2176 8 evolution evolution NN cord-009571-mygj2nd4 2176 9 . . . cord-009571-mygj2nd4 2177 1 Cryoglobulins Cryoglobulins NNP cord-009571-mygj2nd4 2177 2 consisting consist VBG cord-009571-mygj2nd4 2177 3 of of IN cord-009571-mygj2nd4 2177 4 IgG IgG NNP cord-009571-mygj2nd4 2177 5 , , , cord-009571-mygj2nd4 2177 6 IgM IgM NNP cord-009571-mygj2nd4 2177 7 , , , cord-009571-mygj2nd4 2177 8 and and CC cord-009571-mygj2nd4 2177 9 C3 C3 NNP cord-009571-mygj2nd4 2177 10 , , , cord-009571-mygj2nd4 2177 11 C4 C4 NNP cord-009571-mygj2nd4 2177 12 were be VBD cord-009571-mygj2nd4 2177 13 found find VBN cord-009571-mygj2nd4 2177 14 in in IN cord-009571-mygj2nd4 2177 15 3 3 CD cord-009571-mygj2nd4 2177 16 of of IN cord-009571-mygj2nd4 2177 17 4 4 CD cord-009571-mygj2nd4 2177 18 patients patient NNS cord-009571-mygj2nd4 2177 19 . . . cord-009571-mygj2nd4 2178 1 Immune immune JJ cord-009571-mygj2nd4 2178 2 complexes complex NNS cord-009571-mygj2nd4 2178 3 ( ( -LRB- cord-009571-mygj2nd4 2178 4 Raji Raji NNP cord-009571-mygj2nd4 2178 5 cell cell NN cord-009571-mygj2nd4 2178 6 ) ) -RRB- cord-009571-mygj2nd4 2178 7 were be VBD cord-009571-mygj2nd4 2178 8 found find VBN cord-009571-mygj2nd4 2178 9 in in IN cord-009571-mygj2nd4 2178 10 3 3 CD cord-009571-mygj2nd4 2178 11 of of IN cord-009571-mygj2nd4 2178 12 3 3 CD cord-009571-mygj2nd4 2178 13 patients patient NNS cord-009571-mygj2nd4 2178 14 , , , cord-009571-mygj2nd4 2178 15 including include VBG cord-009571-mygj2nd4 2178 16 1 1 CD cord-009571-mygj2nd4 2178 17 patient patient NN cord-009571-mygj2nd4 2178 18 with with IN cord-009571-mygj2nd4 2178 19 absent absent JJ cord-009571-mygj2nd4 2178 20 cryoglobulins cryoglobulin NNS cord-009571-mygj2nd4 2178 21 . . . cord-009571-mygj2nd4 2179 1 Synovial synovial JJ cord-009571-mygj2nd4 2179 2 fluid fluid JJ cord-009571-mygj2nd4 2179 3 analysis analysis NN cord-009571-mygj2nd4 2179 4 in in IN cord-009571-mygj2nd4 2179 5 3 3 CD cord-009571-mygj2nd4 2179 6 patients patient NNS cord-009571-mygj2nd4 2179 7 revealed reveal VBD cord-009571-mygj2nd4 2179 8 California California NNP cord-009571-mygj2nd4 2179 9 WBC WBC NNP cord-009571-mygj2nd4 2179 10 ranging range VBG cord-009571-mygj2nd4 2179 11 from from IN cord-009571-mygj2nd4 2179 12 1200 1200 CD cord-009571-mygj2nd4 2179 13 to to IN cord-009571-mygj2nd4 2179 14 5800 5800 CD cord-009571-mygj2nd4 2179 15 with with IN cord-009571-mygj2nd4 2179 16 from from IN cord-009571-mygj2nd4 2179 17 20 20 CD cord-009571-mygj2nd4 2179 18 to to TO cord-009571-mygj2nd4 2179 19 75 75 CD cord-009571-mygj2nd4 2179 20 % % NN cord-009571-mygj2nd4 2179 21 PMN PMN NNP cord-009571-mygj2nd4 2179 22 . . . cord-009571-mygj2nd4 2180 1 Immune immune JJ cord-009571-mygj2nd4 2180 2 complexes complex NNS cord-009571-mygj2nd4 2180 3 ( ( -LRB- cord-009571-mygj2nd4 2180 4 Raji Raji NNP cord-009571-mygj2nd4 2180 5 cell cell NN cord-009571-mygj2nd4 2180 6 ) ) -RRB- cord-009571-mygj2nd4 2180 7 were be VBD cord-009571-mygj2nd4 2180 8 found find VBN cord-009571-mygj2nd4 2180 9 in in IN cord-009571-mygj2nd4 2180 10 3 3 CD cord-009571-mygj2nd4 2180 11 of of IN cord-009571-mygj2nd4 2180 12 3 3 CD cord-009571-mygj2nd4 2180 13 synovial synovial JJ cord-009571-mygj2nd4 2180 14 fluids fluid NNS cord-009571-mygj2nd4 2180 15 . . . cord-009571-mygj2nd4 2181 1 Excisional excisional JJ cord-009571-mygj2nd4 2181 2 biopsies biopsy NNS cord-009571-mygj2nd4 2181 3 of of IN cord-009571-mygj2nd4 2181 4 the the DT cord-009571-mygj2nd4 2181 5 skin skin NN cord-009571-mygj2nd4 2181 6 lesions lesion NNS cord-009571-mygj2nd4 2181 7 were be VBD cord-009571-mygj2nd4 2181 8 performed perform VBN cord-009571-mygj2nd4 2181 9 in in IN cord-009571-mygj2nd4 2181 10 3 3 CD cord-009571-mygj2nd4 2181 11 patients patient NNS cord-009571-mygj2nd4 2181 12 . . . cord-009571-mygj2nd4 2182 1 There there EX cord-009571-mygj2nd4 2182 2 were be VBD cord-009571-mygj2nd4 2182 3 no no DT cord-009571-mygj2nd4 2182 4 areas area NNS cord-009571-mygj2nd4 2182 5 of of IN cord-009571-mygj2nd4 2182 6 fat fat JJ cord-009571-mygj2nd4 2182 7 necrosis necrosis NN cord-009571-mygj2nd4 2182 8 . . . cord-009571-mygj2nd4 2183 1 Small small JJ cord-009571-mygj2nd4 2183 2 capillaries capillary NNS cord-009571-mygj2nd4 2183 3 and and CC cord-009571-mygj2nd4 2183 4 venules venule NNS cord-009571-mygj2nd4 2183 5 were be VBD cord-009571-mygj2nd4 2183 6 infiltrated infiltrate VBN cord-009571-mygj2nd4 2183 7 with with IN cord-009571-mygj2nd4 2183 8 PMN PMN NNP cord-009571-mygj2nd4 2183 9 in in IN cord-009571-mygj2nd4 2183 10 all all DT cord-009571-mygj2nd4 2183 11 cases case NNS cord-009571-mygj2nd4 2183 12 . . . cord-009571-mygj2nd4 2184 1 Immunofluorescent Immunofluorescent NNP cord-009571-mygj2nd4 2184 2 stains stain NNS cord-009571-mygj2nd4 2184 3 revealed reveal VBD cord-009571-mygj2nd4 2184 4 deposits deposit NNS cord-009571-mygj2nd4 2184 5 of of IN cord-009571-mygj2nd4 2184 6 IgG igg NN cord-009571-mygj2nd4 2184 7 and and CC cord-009571-mygj2nd4 2184 8 C3-C4 C3-C4 NNP cord-009571-mygj2nd4 2184 9 in in IN cord-009571-mygj2nd4 2184 10 vessel vessel NN cord-009571-mygj2nd4 2184 11 walls wall NNS cord-009571-mygj2nd4 2184 12 in in IN cord-009571-mygj2nd4 2184 13 1 1 CD cord-009571-mygj2nd4 2184 14 of of IN cord-009571-mygj2nd4 2184 15 3 3 CD cord-009571-mygj2nd4 2184 16 patients patient NNS cord-009571-mygj2nd4 2184 17 . . . cord-009571-mygj2nd4 2185 1 Fluorescein Fluorescein NNP cord-009571-mygj2nd4 2185 2 conjugated conjugate VBD cord-009571-mygj2nd4 2185 3 antisera antisera NN cord-009571-mygj2nd4 2185 4 against against IN cord-009571-mygj2nd4 2185 5 5 5 CD cord-009571-mygj2nd4 2185 6 bacterial bacterial JJ cord-009571-mygj2nd4 2185 7 pathogens pathogen NNS cord-009571-mygj2nd4 2185 8 revealed reveal VBD cord-009571-mygj2nd4 2185 9 no no DT cord-009571-mygj2nd4 2185 10 staining staining NN cord-009571-mygj2nd4 2185 11 in in IN cord-009571-mygj2nd4 2185 12 1 1 CD cord-009571-mygj2nd4 2185 13 patient patient NN cord-009571-mygj2nd4 2185 14 . . . cord-009571-mygj2nd4 2186 1 Treatment treatment NN cord-009571-mygj2nd4 2186 2 with with IN cord-009571-mygj2nd4 2186 3 oral oral JJ cord-009571-mygj2nd4 2186 4 antibiotics antibiotic NNS cord-009571-mygj2nd4 2186 5 was be VBD cord-009571-mygj2nd4 2186 6 initiated initiate VBN cord-009571-mygj2nd4 2186 7 in in IN cord-009571-mygj2nd4 2186 8 all all DT cord-009571-mygj2nd4 2186 9 patients patient NNS cord-009571-mygj2nd4 2186 10 but but CC cord-009571-mygj2nd4 2186 11 was be VBD cord-009571-mygj2nd4 2186 12 not not RB cord-009571-mygj2nd4 2186 13 invariably invariably RB cord-009571-mygj2nd4 2186 14 successful successful JJ cord-009571-mygj2nd4 2186 15 in in IN cord-009571-mygj2nd4 2186 16 decreasing decrease VBG cord-009571-mygj2nd4 2186 17 the the DT cord-009571-mygj2nd4 2186 18 dermatitis dermatitis NN cord-009571-mygj2nd4 2186 19 or or CC cord-009571-mygj2nd4 2186 20 arthritis arthritis NN cord-009571-mygj2nd4 2186 21 . . . cord-009571-mygj2nd4 2187 1 In in IN cord-009571-mygj2nd4 2187 2 2 2 CD cord-009571-mygj2nd4 2187 3 patients patient NNS cord-009571-mygj2nd4 2187 4 , , , cord-009571-mygj2nd4 2187 5 intravenous intravenous JJ cord-009571-mygj2nd4 2187 6 antibiotics antibiotic NNS cord-009571-mygj2nd4 2187 7 were be VBD cord-009571-mygj2nd4 2187 8 also also RB cord-009571-mygj2nd4 2187 9 unsuccessful unsuccessful JJ cord-009571-mygj2nd4 2187 10 , , , cord-009571-mygj2nd4 2187 11 but but CC cord-009571-mygj2nd4 2187 12 oral oral JJ cord-009571-mygj2nd4 2187 13 prednisone prednisone NN cord-009571-mygj2nd4 2187 14 was be VBD cord-009571-mygj2nd4 2187 15 promptly promptly RB cord-009571-mygj2nd4 2187 16 followed follow VBN cord-009571-mygj2nd4 2187 17 by by IN cord-009571-mygj2nd4 2187 18 decreased decrease VBN cord-009571-mygj2nd4 2187 19 dermatitis dermatitis NN cord-009571-mygj2nd4 2187 20 - - HYPH cord-009571-mygj2nd4 2187 21 arthritis arthritis NN cord-009571-mygj2nd4 2187 22 . . . cord-009571-mygj2nd4 2188 1 In in IN cord-009571-mygj2nd4 2188 2 responsive responsive JJ cord-009571-mygj2nd4 2188 3 patients patient NNS cord-009571-mygj2nd4 2188 4 , , , cord-009571-mygj2nd4 2188 5 the the DT cord-009571-mygj2nd4 2188 6 serum serum NN cord-009571-mygj2nd4 2188 7 cryoprotein cryoprotein NNP cord-009571-mygj2nd4 2188 8 titer titer NN cord-009571-mygj2nd4 2188 9 decreased decrease VBD cord-009571-mygj2nd4 2188 10 ; ; : cord-009571-mygj2nd4 2188 11 the the DT cord-009571-mygj2nd4 2188 12 kinetics kinetic NNS cord-009571-mygj2nd4 2188 13 of of IN cord-009571-mygj2nd4 2188 14 this this DT cord-009571-mygj2nd4 2188 15 decrease decrease NN cord-009571-mygj2nd4 2188 16 and and CC cord-009571-mygj2nd4 2188 17 the the DT cord-009571-mygj2nd4 2188 18 reappearence reappearence NN cord-009571-mygj2nd4 2188 19 of of IN cord-009571-mygj2nd4 2188 20 the the DT cord-009571-mygj2nd4 2188 21 cryoprotein cryoprotein NNP cord-009571-mygj2nd4 2188 22 after after IN cord-009571-mygj2nd4 2188 23 stopping stop VBG cord-009571-mygj2nd4 2188 24 antibiotic antibiotic JJ cord-009571-mygj2nd4 2188 25 - - HYPH cord-009571-mygj2nd4 2188 26 prednisone prednisone JJ cord-009571-mygj2nd4 2188 27 treatment treatment NN cord-009571-mygj2nd4 2188 28 was be VBD cord-009571-mygj2nd4 2188 29 studied study VBN cord-009571-mygj2nd4 2188 30 . . . cord-009571-mygj2nd4 2189 1 Post post JJ cord-009571-mygj2nd4 2189 2 - - JJ cord-009571-mygj2nd4 2189 3 intestinal intestinal JJ cord-009571-mygj2nd4 2189 4 bypass bypass NN cord-009571-mygj2nd4 2189 5 surgery surgery NN cord-009571-mygj2nd4 2189 6 may may MD cord-009571-mygj2nd4 2189 7 cause cause VB cord-009571-mygj2nd4 2189 8 a a DT cord-009571-mygj2nd4 2189 9 systemic systemic JJ cord-009571-mygj2nd4 2189 10 immune immune JJ cord-009571-mygj2nd4 2189 11 complex complex JJ cord-009571-mygj2nd4 2189 12 disease disease NN cord-009571-mygj2nd4 2189 13 primarily primarily RB cord-009571-mygj2nd4 2189 14 involving involve VBG cord-009571-mygj2nd4 2189 15 joints joint NNS cord-009571-mygj2nd4 2189 16 and and CC cord-009571-mygj2nd4 2189 17 skin skin NN cord-009571-mygj2nd4 2189 18 . . . cord-009571-mygj2nd4 2190 1 Each each DT cord-009571-mygj2nd4 2190 2 met meet VBD cord-009571-mygj2nd4 2190 3 at at RB cord-009571-mygj2nd4 2190 4 least least JJS cord-009571-mygj2nd4 2190 5 4 4 CD cord-009571-mygj2nd4 2190 6 SLE SLE NNP cord-009571-mygj2nd4 2190 7 classification classification NN cord-009571-mygj2nd4 2190 8 criteria criterion NNS cord-009571-mygj2nd4 2190 9 , , , cord-009571-mygj2nd4 2190 10 had have VBD cord-009571-mygj2nd4 2190 11 2 2 CD cord-009571-mygj2nd4 2190 12 clinical clinical JJ cord-009571-mygj2nd4 2190 13 criteria criterion NNS cord-009571-mygj2nd4 2190 14 of of IN cord-009571-mygj2nd4 2190 15 disease disease NN cord-009571-mygj2nd4 2190 16 activity activity NN cord-009571-mygj2nd4 2190 17 , , , cord-009571-mygj2nd4 2190 18 and and CC cord-009571-mygj2nd4 2190 19 had have VBD cord-009571-mygj2nd4 2190 20 elevated elevate VBN cord-009571-mygj2nd4 2190 21 serum serum NN cord-009571-mygj2nd4 2190 22 DNA dna NN cord-009571-mygj2nd4 2190 23 binding binding NN cord-009571-mygj2nd4 2190 24 ( ( -LRB- cord-009571-mygj2nd4 2190 25 30 30 CD cord-009571-mygj2nd4 2190 26 - - SYM cord-009571-mygj2nd4 2190 27 93 93 CD cord-009571-mygj2nd4 2190 28 % % NN cord-009571-mygj2nd4 2190 29 by by IN cord-009571-mygj2nd4 2190 30 Farr Farr NNP cord-009571-mygj2nd4 2190 31 assay assay NN cord-009571-mygj2nd4 2190 32 ) ) -RRB- cord-009571-mygj2nd4 2190 33 . . . cord-009571-mygj2nd4 2191 1 Three three CD cord-009571-mygj2nd4 2191 2 had have VBD cord-009571-mygj2nd4 2191 3 low low JJ cord-009571-mygj2nd4 2191 4 serum serum NN cord-009571-mygj2nd4 2191 5 hemolytic hemolytic JJ cord-009571-mygj2nd4 2191 6 complement complement NN cord-009571-mygj2nd4 2191 7 levels level NNS cord-009571-mygj2nd4 2191 8 ( ( -LRB- cord-009571-mygj2nd4 2191 9 62 62 CD cord-009571-mygj2nd4 2191 10 - - SYM cord-009571-mygj2nd4 2191 11 89 89 CD cord-009571-mygj2nd4 2191 12 U u NN cord-009571-mygj2nd4 2191 13 ) ) -RRB- cord-009571-mygj2nd4 2191 14 . . . cord-009571-mygj2nd4 2192 1 Their -PRON- PRP$ cord-009571-mygj2nd4 2192 2 drug drug NN cord-009571-mygj2nd4 2192 3 regimen regimen NN cord-009571-mygj2nd4 2192 4 , , , cord-009571-mygj2nd4 2192 5 including include VBG cord-009571-mygj2nd4 2192 6 prednisone prednisone NNP cord-009571-mygj2nd4 2192 7 ( ( -LRB- cord-009571-mygj2nd4 2192 8 20 20 CD cord-009571-mygj2nd4 2192 9 - - SYM cord-009571-mygj2nd4 2192 10 45 45 CD cord-009571-mygj2nd4 2192 11 mg mg NNP cord-009571-mygj2nd4 2192 12 / / SYM cord-009571-mygj2nd4 2192 13 day day NN cord-009571-mygj2nd4 2192 14 ) ) -RRB- cord-009571-mygj2nd4 2192 15 , , , cord-009571-mygj2nd4 2192 16 remained remain VBD cord-009571-mygj2nd4 2192 17 stable stable JJ cord-009571-mygj2nd4 2192 18 for for IN cord-009571-mygj2nd4 2192 19 2 2 CD cord-009571-mygj2nd4 2192 20 I -PRON- PRP cord-009571-mygj2nd4 2192 21 days day NNS cord-009571-mygj2nd4 2192 22 prior prior RB cord-009571-mygj2nd4 2192 23 to to IN cord-009571-mygj2nd4 2192 24 , , , cord-009571-mygj2nd4 2192 25 during during IN cord-009571-mygj2nd4 2192 26 , , , cord-009571-mygj2nd4 2192 27 and and CC cord-009571-mygj2nd4 2192 28 for for IN cord-009571-mygj2nd4 2192 29 28 28 CD cord-009571-mygj2nd4 2192 30 days day NNS cord-009571-mygj2nd4 2192 31 after after IN cord-009571-mygj2nd4 2192 32 Frentizole Frentizole NNP cord-009571-mygj2nd4 2192 33 therapy therapy NN cord-009571-mygj2nd4 2192 34 . . . cord-009571-mygj2nd4 2193 1 Rash Rash NNP cord-009571-mygj2nd4 2193 2 ( ( -LRB- cord-009571-mygj2nd4 2193 3 4 4 CD cord-009571-mygj2nd4 2193 4 of of IN cord-009571-mygj2nd4 2193 5 6 6 CD cord-009571-mygj2nd4 2193 6 ) ) -RRB- cord-009571-mygj2nd4 2193 7 , , , cord-009571-mygj2nd4 2193 8 synovitis synovitis NNP cord-009571-mygj2nd4 2193 9 ( ( -LRB- cord-009571-mygj2nd4 2193 10 4 4 CD cord-009571-mygj2nd4 2193 11 of of IN cord-009571-mygj2nd4 2193 12 6 6 CD cord-009571-mygj2nd4 2193 13 ) ) -RRB- cord-009571-mygj2nd4 2193 14 , , , cord-009571-mygj2nd4 2193 15 mucosal mucosal JJ cord-009571-mygj2nd4 2193 16 ulcers ulcer NNS cord-009571-mygj2nd4 2193 17 ( ( -LRB- cord-009571-mygj2nd4 2193 18 3 3 CD cord-009571-mygj2nd4 2193 19 of of IN cord-009571-mygj2nd4 2193 20 3 3 CD cord-009571-mygj2nd4 2193 21 ) ) -RRB- cord-009571-mygj2nd4 2193 22 , , , cord-009571-mygj2nd4 2193 23 and and CC cord-009571-mygj2nd4 2193 24 pleurisy pleurisy NN cord-009571-mygj2nd4 2193 25 ( ( -LRB- cord-009571-mygj2nd4 2193 26 1 1 CD cord-009571-mygj2nd4 2193 27 of of IN cord-009571-mygj2nd4 2193 28 1 1 CD cord-009571-mygj2nd4 2193 29 ) ) -RRB- cord-009571-mygj2nd4 2193 30 improved improve VBD cord-009571-mygj2nd4 2193 31 during during IN cord-009571-mygj2nd4 2193 32 Frentizole Frentizole NNP cord-009571-mygj2nd4 2193 33 therapy therapy NN cord-009571-mygj2nd4 2193 34 . . . cord-009571-mygj2nd4 2194 1 Synovitis Synovitis NNP cord-009571-mygj2nd4 2194 2 worsened worsen VBD cord-009571-mygj2nd4 2194 3 in in IN cord-009571-mygj2nd4 2194 4 1 1 CD cord-009571-mygj2nd4 2194 5 case case NN cord-009571-mygj2nd4 2194 6 . . . cord-009571-mygj2nd4 2195 1 The the DT cord-009571-mygj2nd4 2195 2 only only JJ cord-009571-mygj2nd4 2195 3 toxicity toxicity NN cord-009571-mygj2nd4 2195 4 was be VBD cord-009571-mygj2nd4 2195 5 transient transient JJ cord-009571-mygj2nd4 2195 6 SGOT SGOT NNP cord-009571-mygj2nd4 2195 7 and and CC cord-009571-mygj2nd4 2195 8 SGPT SGPT NNP cord-009571-mygj2nd4 2195 9 elevation elevation NN cord-009571-mygj2nd4 2195 10 in in IN cord-009571-mygj2nd4 2195 11 2 2 CD cord-009571-mygj2nd4 2195 12 cases case NNS cord-009571-mygj2nd4 2195 13 . . . cord-009571-mygj2nd4 2196 1 Bone bone NN cord-009571-mygj2nd4 2196 2 marrow marrow NN cord-009571-mygj2nd4 2196 3 and and CC cord-009571-mygj2nd4 2196 4 skin skin NN cord-009571-mygj2nd4 2196 5 tests test NNS cord-009571-mygj2nd4 2196 6 were be VBD cord-009571-mygj2nd4 2196 7 not not RB cord-009571-mygj2nd4 2196 8 suppressed suppress VBN cord-009571-mygj2nd4 2196 9 by by IN cord-009571-mygj2nd4 2196 10 the the DT cord-009571-mygj2nd4 2196 11 drug drug NN cord-009571-mygj2nd4 2196 12 . . . cord-009571-mygj2nd4 2197 1 Frentizole Frentizole NNP cord-009571-mygj2nd4 2197 2 had have VBD cord-009571-mygj2nd4 2197 3 no no DT cord-009571-mygj2nd4 2197 4 effect effect NN cord-009571-mygj2nd4 2197 5 on on IN cord-009571-mygj2nd4 2197 6 hemoglobin hemoglobin NN cord-009571-mygj2nd4 2197 7 concentration concentration NN cord-009571-mygj2nd4 2197 8 , , , cord-009571-mygj2nd4 2197 9 creatinine creatinine NN cord-009571-mygj2nd4 2197 10 clearance clearance NN cord-009571-mygj2nd4 2197 11 , , , cord-009571-mygj2nd4 2197 12 or or CC cord-009571-mygj2nd4 2197 13 urinary urinary JJ cord-009571-mygj2nd4 2197 14 protein protein NN cord-009571-mygj2nd4 2197 15 ex ex NN cord-009571-mygj2nd4 2197 16 - - NN cord-009571-mygj2nd4 2197 17 response response NN cord-009571-mygj2nd4 2197 18 . . . cord-009571-mygj2nd4 2198 1 Other other JJ cord-009571-mygj2nd4 2198 2 laboratory laboratory NN cord-009571-mygj2nd4 2198 3 findings finding NNS cord-009571-mygj2nd4 2198 4 ( ( -LRB- cord-009571-mygj2nd4 2198 5 mean mean VB cord-009571-mygj2nd4 2198 6 f f NNP cord-009571-mygj2nd4 2198 7 SEM SEM NNP cord-009571-mygj2nd4 2198 8 ) ) -RRB- cord-009571-mygj2nd4 2198 9 are be VBP cord-009571-mygj2nd4 2198 10 summarized summarize VBN cord-009571-mygj2nd4 2198 11 in in IN cord-009571-mygj2nd4 2198 12 the the DT cord-009571-mygj2nd4 2198 13 table table NN cord-009571-mygj2nd4 2198 14 . . . cord-009571-mygj2nd4 2199 1 These these DT cord-009571-mygj2nd4 2199 2 results result NNS cord-009571-mygj2nd4 2199 3 suggest suggest VBP cord-009571-mygj2nd4 2199 4 that that IN cord-009571-mygj2nd4 2199 5 Frentizole Frentizole NNP cord-009571-mygj2nd4 2199 6 is be VBZ cord-009571-mygj2nd4 2199 7 an an DT cord-009571-mygj2nd4 2199 8 active active JJ cord-009571-mygj2nd4 2199 9 , , , cord-009571-mygj2nd4 2199 10 relatively relatively RB cord-009571-mygj2nd4 2199 11 non non JJ cord-009571-mygj2nd4 2199 12 - - JJ cord-009571-mygj2nd4 2199 13 toxic toxic JJ cord-009571-mygj2nd4 2199 14 immunoregulatory immunoregulatory JJ cord-009571-mygj2nd4 2199 15 drug drug NN cord-009571-mygj2nd4 2199 16 in in IN cord-009571-mygj2nd4 2199 17 SLE SLE NNP cord-009571-mygj2nd4 2199 18 patients patient NNS cord-009571-mygj2nd4 2199 19 . . . cord-009571-mygj2nd4 2200 1 Current current JJ cord-009571-mygj2nd4 2200 2 long long JJ cord-009571-mygj2nd4 2200 3 - - HYPH cord-009571-mygj2nd4 2200 4 term term NN cord-009571-mygj2nd4 2200 5 studies study NNS cord-009571-mygj2nd4 2200 6 should should MD cord-009571-mygj2nd4 2200 7 define define VB cord-009571-mygj2nd4 2200 8 its -PRON- PRP$ cord-009571-mygj2nd4 2200 9 role role NN cord-009571-mygj2nd4 2200 10 in in IN cord-009571-mygj2nd4 2200 11 the the DT cord-009571-mygj2nd4 2200 12 therapy therapy NN cord-009571-mygj2nd4 2200 13 of of IN cord-009571-mygj2nd4 2200 14 SLE SLE NNP cord-009571-mygj2nd4 2200 15 and and CC cord-009571-mygj2nd4 2200 16 other other JJ cord-009571-mygj2nd4 2200 17 autoimmune autoimmune JJ cord-009571-mygj2nd4 2200 18 diseases disease NNS cord-009571-mygj2nd4 2200 19 . . . cord-009571-mygj2nd4 2200 20 _SP cord-009571-mygj2nd4 2201 1 Clinical clinical JJ cord-009571-mygj2nd4 2201 2 and and CC cord-009571-mygj2nd4 2201 3 laboratory laboratory NN cord-009571-mygj2nd4 2201 4 findings finding NNS cord-009571-mygj2nd4 2201 5 of of IN cord-009571-mygj2nd4 2201 6 45 45 CD cord-009571-mygj2nd4 2201 7 children child NNS cord-009571-mygj2nd4 2201 8 with with IN cord-009571-mygj2nd4 2201 9 systemic systemic JJ cord-009571-mygj2nd4 2201 10 lupus lupus NN cord-009571-mygj2nd4 2201 11 erythematosus erythematosus NN cord-009571-mygj2nd4 2201 12 ( ( -LRB- cord-009571-mygj2nd4 2201 13 SLE SLE NNP cord-009571-mygj2nd4 2201 14 ) ) -RRB- cord-009571-mygj2nd4 2201 15 prospectively prospectively RB cord-009571-mygj2nd4 2201 16 followed follow VBN cord-009571-mygj2nd4 2201 17 since since IN cord-009571-mygj2nd4 2201 18 1962 1962 CD cord-009571-mygj2nd4 2201 19 have have VBP cord-009571-mygj2nd4 2201 20 been be VBN cord-009571-mygj2nd4 2201 21 summarized summarize VBN cord-009571-mygj2nd4 2201 22 . . . cord-009571-mygj2nd4 2202 1 Mean mean JJ cord-009571-mygj2nd4 2202 2 disease disease NN cord-009571-mygj2nd4 2202 3 duration duration NN cord-009571-mygj2nd4 2202 4 was be VBD cord-009571-mygj2nd4 2202 5 5.3 5.3 CD cord-009571-mygj2nd4 2202 6 years year NNS cord-009571-mygj2nd4 2203 1 ( ( -LRB- cord-009571-mygj2nd4 2203 2 range range NN cord-009571-mygj2nd4 2203 3 2 2 CD cord-009571-mygj2nd4 2203 4 months month NNS cord-009571-mygj2nd4 2203 5 to to IN cord-009571-mygj2nd4 2203 6 16 16 CD cord-009571-mygj2nd4 2203 7 years year NNS cord-009571-mygj2nd4 2203 8 , , , cord-009571-mygj2nd4 2203 9 median median NN cord-009571-mygj2nd4 2203 10 5 5 CD cord-009571-mygj2nd4 2203 11 years year NNS cord-009571-mygj2nd4 2203 12 ) ) -RRB- cord-009571-mygj2nd4 2203 13 . . . cord-009571-mygj2nd4 2204 1 There there EX cord-009571-mygj2nd4 2204 2 were be VBD cord-009571-mygj2nd4 2204 3 34 34 CD cord-009571-mygj2nd4 2204 4 girls girl NNS cord-009571-mygj2nd4 2204 5 and and CC cord-009571-mygj2nd4 2204 6 1 1 CD cord-009571-mygj2nd4 2204 7 1 1 CD cord-009571-mygj2nd4 2204 8 boys boy NNS cord-009571-mygj2nd4 2204 9 , , , cord-009571-mygj2nd4 2204 10 less less JJR cord-009571-mygj2nd4 2204 11 of of IN cord-009571-mygj2nd4 2204 12 a a DT cord-009571-mygj2nd4 2204 13 female female JJ cord-009571-mygj2nd4 2204 14 preponderance preponderance NN cord-009571-mygj2nd4 2204 15 than than IN cord-009571-mygj2nd4 2204 16 that that DT cord-009571-mygj2nd4 2204 17 of of IN cord-009571-mygj2nd4 2204 18 most most JJS cord-009571-mygj2nd4 2204 19 adult adult NN cord-009571-mygj2nd4 2204 20 series series NN cord-009571-mygj2nd4 2204 21 . . . cord-009571-mygj2nd4 2205 1 Youngest young JJS cord-009571-mygj2nd4 2205 2 age age NN cord-009571-mygj2nd4 2205 3 for for IN cord-009571-mygj2nd4 2205 4 onset onset NN cord-009571-mygj2nd4 2205 5 of of IN cord-009571-mygj2nd4 2205 6 systemic systemic JJ cord-009571-mygj2nd4 2205 7 complaints complaint NNS cord-009571-mygj2nd4 2205 8 was be VBD cord-009571-mygj2nd4 2205 9 4 4 CD cord-009571-mygj2nd4 2205 10 years year NNS cord-009571-mygj2nd4 2205 11 . . . cord-009571-mygj2nd4 2206 1 Ten ten CD cord-009571-mygj2nd4 2206 2 of of IN cord-009571-mygj2nd4 2206 3 11 11 CD cord-009571-mygj2nd4 2206 4 boys boy NNS cord-009571-mygj2nd4 2206 5 had have VBD cord-009571-mygj2nd4 2206 6 disease disease NN cord-009571-mygj2nd4 2206 7 onset onset NN cord-009571-mygj2nd4 2206 8 prior prior RB cord-009571-mygj2nd4 2206 9 to to IN cord-009571-mygj2nd4 2206 10 sexual sexual JJ cord-009571-mygj2nd4 2206 11 maturation maturation NN cord-009571-mygj2nd4 2206 12 , , , cord-009571-mygj2nd4 2206 13 whereas whereas IN cord-009571-mygj2nd4 2206 14 disease disease NN cord-009571-mygj2nd4 2206 15 began begin VBD cord-009571-mygj2nd4 2206 16 after after IN cord-009571-mygj2nd4 2206 17 menarche menarche NN cord-009571-mygj2nd4 2206 18 in in IN cord-009571-mygj2nd4 2206 19 ADCC ADCC NNP cord-009571-mygj2nd4 2206 20 activity activity NN cord-009571-mygj2nd4 2206 21 between between IN cord-009571-mygj2nd4 2206 22 patient patient NN cord-009571-mygj2nd4 2206 23 cells cell NNS cord-009571-mygj2nd4 2206 24 and and CC cord-009571-mygj2nd4 2206 25 control control NN cord-009571-mygj2nd4 2206 26 cells cell NNS cord-009571-mygj2nd4 2206 27 when when WRB cord-009571-mygj2nd4 2206 28 either either CC cord-009571-mygj2nd4 2206 29 the the DT cord-009571-mygj2nd4 2206 30 mixed mixed JJ cord-009571-mygj2nd4 2206 31 mononuclear mononuclear JJ cord-009571-mygj2nd4 2206 32 population population NN cord-009571-mygj2nd4 2206 33 or or CC cord-009571-mygj2nd4 2206 34 monocyte monocyte NNP cord-009571-mygj2nd4 2206 35 - - HYPH cord-009571-mygj2nd4 2206 36 depleted deplete VBN cord-009571-mygj2nd4 2206 37 population population NN cord-009571-mygj2nd4 2206 38 were be VBD cord-009571-mygj2nd4 2206 39 studied study VBN cord-009571-mygj2nd4 2206 40 as as IN cord-009571-mygj2nd4 2206 41 effectors effector NNS cord-009571-mygj2nd4 2206 42 . . . cord-009571-mygj2nd4 2207 1 The the DT cord-009571-mygj2nd4 2207 2 monocyteenriched monocyteenriched JJ cord-009571-mygj2nd4 2207 3 fraction fraction NN cord-009571-mygj2nd4 2207 4 from from IN cord-009571-mygj2nd4 2207 5 patients patient NNS cord-009571-mygj2nd4 2207 6 with with IN cord-009571-mygj2nd4 2207 7 RA RA NNP cord-009571-mygj2nd4 2207 8 , , , cord-009571-mygj2nd4 2207 9 however however RB cord-009571-mygj2nd4 2207 10 , , , cord-009571-mygj2nd4 2207 11 mediated mediate VBD cord-009571-mygj2nd4 2207 12 a a DT cord-009571-mygj2nd4 2207 13 significantly significantly RB cord-009571-mygj2nd4 2207 14 increased increase VBN cord-009571-mygj2nd4 2207 15 degree degree NN cord-009571-mygj2nd4 2207 16 of of IN cord-009571-mygj2nd4 2207 17 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 2207 18 ( ( -LRB- cord-009571-mygj2nd4 2207 19 Table table NN cord-009571-mygj2nd4 2207 20 ) ) -RRB- cord-009571-mygj2nd4 2207 21 . . . cord-009571-mygj2nd4 2208 1 Enhanced enhanced JJ cord-009571-mygj2nd4 2208 2 cytotoxicity cytotoxicity NN cord-009571-mygj2nd4 2208 3 was be VBD cord-009571-mygj2nd4 2208 4 more more RBR cord-009571-mygj2nd4 2208 5 evident evident JJ cord-009571-mygj2nd4 2208 6 at at IN cord-009571-mygj2nd4 2208 7 low low JJ cord-009571-mygj2nd4 2208 8 effector effector NN cord-009571-mygj2nd4 2208 9 : : : cord-009571-mygj2nd4 2208 10 target target NN cord-009571-mygj2nd4 2208 11 ratios ratio NNS cord-009571-mygj2nd4 2208 12 and and CC cord-009571-mygj2nd4 2208 13 was be VBD cord-009571-mygj2nd4 2208 14 independent independent JJ cord-009571-mygj2nd4 2208 15 of of IN cord-009571-mygj2nd4 2208 16 phagocytosis phagocytosis NN cord-009571-mygj2nd4 2208 17 . . . cord-009571-mygj2nd4 2209 1 ADCC ADCC NNP cord-009571-mygj2nd4 2209 2 may may MD cord-009571-mygj2nd4 2209 3 be be VB cord-009571-mygj2nd4 2209 4 important important JJ cord-009571-mygj2nd4 2209 5 in in IN cord-009571-mygj2nd4 2209 6 RA RA NNP cord-009571-mygj2nd4 2209 7 since since IN cord-009571-mygj2nd4 2209 8 it -PRON- PRP cord-009571-mygj2nd4 2209 9 reflects reflect VBZ cord-009571-mygj2nd4 2209 10 both both CC cord-009571-mygj2nd4 2209 11 humoral humoral JJ cord-009571-mygj2nd4 2209 12 and and CC cord-009571-mygj2nd4 2209 13 cell cell NN cord-009571-mygj2nd4 2209 14 - - HYPH cord-009571-mygj2nd4 2209 15 mediated mediate VBN cord-009571-mygj2nd4 2209 16 immune immune JJ cord-009571-mygj2nd4 2209 17 mechanisms mechanism NNS cord-009571-mygj2nd4 2209 18 . . . cord-009571-mygj2nd4 2210 1 The the DT cord-009571-mygj2nd4 2210 2 enhanced enhanced JJ cord-009571-mygj2nd4 2210 3 effector effector NN cord-009571-mygj2nd4 2210 4 function function NN cord-009571-mygj2nd4 2210 5 of of IN cord-009571-mygj2nd4 2210 6 the the DT cord-009571-mygj2nd4 2210 7 peripheral peripheral JJ cord-009571-mygj2nd4 2210 8 blood blood NN cord-009571-mygj2nd4 2210 9 monocyte monocyte NNP cord-009571-mygj2nd4 2210 10 in in IN cord-009571-mygj2nd4 2210 11 this this DT cord-009571-mygj2nd4 2210 12 system system NN cord-009571-mygj2nd4 2210 13 may may MD cord-009571-mygj2nd4 2210 14 be be VB cord-009571-mygj2nd4 2210 15 an an DT cord-009571-mygj2nd4 2210 16 indication indication NN cord-009571-mygj2nd4 2210 17 that that IN cord-009571-mygj2nd4 2210 18 mononuclear mononuclear JJ cord-009571-mygj2nd4 2210 19 phagocytes phagocyte NNS cord-009571-mygj2nd4 2210 20 are be VBP cord-009571-mygj2nd4 2210 21 " " `` cord-009571-mygj2nd4 2210 22 activated activate VBN cord-009571-mygj2nd4 2210 23 " " '' cord-009571-mygj2nd4 2210 24 in in IN cord-009571-mygj2nd4 2210 25 patients patient NNS cord-009571-mygj2nd4 2210 26 with with IN cord-009571-mygj2nd4 2210 27 RA RA NNP cord-009571-mygj2nd4 2210 28 . . . cord-009571-mygj2nd4 2211 1 The the DT cord-009571-mygj2nd4 2211 2 ARA ARA NNP cord-009571-mygj2nd4 2211 3 Preliminary Preliminary NNP cord-009571-mygj2nd4 2211 4 Criteria Criteria NNP cord-009571-mygj2nd4 2211 5 for for IN cord-009571-mygj2nd4 2211 6 the the DT cord-009571-mygj2nd4 2211 7 Classification Classification NNP cord-009571-mygj2nd4 2211 8 of of IN cord-009571-mygj2nd4 2211 9 systemic systemic JJ cord-009571-mygj2nd4 2211 10 lupus lupus NN cord-009571-mygj2nd4 2211 11 erythematosus erythematosus NN cord-009571-mygj2nd4 2211 12 ( ( -LRB- cord-009571-mygj2nd4 2211 13 SLE SLE NNP cord-009571-mygj2nd4 2211 14 ) ) -RRB- cord-009571-mygj2nd4 2211 15 were be VBD cord-009571-mygj2nd4 2211 16 developed develop VBN cord-009571-mygj2nd4 2211 17 before before IN cord-009571-mygj2nd4 2211 18 the the DT cord-009571-mygj2nd4 2211 19 widespread widespread JJ cord-009571-mygj2nd4 2211 20 use use NN cord-009571-mygj2nd4 2211 21 of of IN cord-009571-mygj2nd4 2211 22 tests test NNS cord-009571-mygj2nd4 2211 23 for for IN cord-009571-mygj2nd4 2211 24 anti anti JJ cord-009571-mygj2nd4 2211 25 - - JJ cord-009571-mygj2nd4 2211 26 DNA dna JJ cord-009571-mygj2nd4 2211 27 antibodies antibody NNS cord-009571-mygj2nd4 2211 28 and and CC cord-009571-mygj2nd4 2211 29 serum serum NN cord-009571-mygj2nd4 2211 30 C3 c3 NN cord-009571-mygj2nd4 2211 31 levels level NNS cord-009571-mygj2nd4 2211 32 . . . cord-009571-mygj2nd4 2212 1 Analysis analysis NN cord-009571-mygj2nd4 2212 2 of of IN cord-009571-mygj2nd4 2212 3 our -PRON- PRP$ cord-009571-mygj2nd4 2212 4 data data NN cord-009571-mygj2nd4 2212 5 suggests suggest VBZ cord-009571-mygj2nd4 2212 6 that that IN cord-009571-mygj2nd4 2212 7 these these DT cord-009571-mygj2nd4 2212 8 tests test NNS cord-009571-mygj2nd4 2212 9 should should MD cord-009571-mygj2nd4 2212 10 be be VB cord-009571-mygj2nd4 2212 11 included include VBN cord-009571-mygj2nd4 2212 12 in in IN cord-009571-mygj2nd4 2212 13 the the DT cord-009571-mygj2nd4 2212 14 ARA ARA NNP cord-009571-mygj2nd4 2212 15 Criteria Criteria NNP cord-009571-mygj2nd4 2212 16 and and CC cord-009571-mygj2nd4 2212 17 could could MD cord-009571-mygj2nd4 2212 18 replace replace VB cord-009571-mygj2nd4 2212 19 2 2 CD cord-009571-mygj2nd4 2212 20 of of IN cord-009571-mygj2nd4 2212 21 the the DT cord-009571-mygj2nd4 2212 22 present present JJ cord-009571-mygj2nd4 2212 23 14 14 CD cord-009571-mygj2nd4 2212 24 manifestations manifestation NNS cord-009571-mygj2nd4 2212 25 which which WDT cord-009571-mygj2nd4 2212 26 are be VBP cord-009571-mygj2nd4 2212 27 less less RBR cord-009571-mygj2nd4 2212 28 specific specific JJ cord-009571-mygj2nd4 2212 29 and and CC cord-009571-mygj2nd4 2212 30 less less RBR cord-009571-mygj2nd4 2212 31 sensitive sensitive JJ cord-009571-mygj2nd4 2212 32 than than IN cord-009571-mygj2nd4 2212 33 the the DT cord-009571-mygj2nd4 2212 34 serum serum NN cord-009571-mygj2nd4 2212 35 C3 c3 NN cord-009571-mygj2nd4 2212 36 level level NN cord-009571-mygj2nd4 2212 37 and and CC cord-009571-mygj2nd4 2212 38 circulating circulate VBG cord-009571-mygj2nd4 2212 39 anti anti JJ cord-009571-mygj2nd4 2212 40 - - JJ cord-009571-mygj2nd4 2212 41 native native JJ cord-009571-mygj2nd4 2212 42 DNA dna NN cord-009571-mygj2nd4 2212 43 antibody antibody NN cord-009571-mygj2nd4 2212 44 level level NN cord-009571-mygj2nd4 2212 45 ( ( -LRB- cord-009571-mygj2nd4 2212 46 a a DT cord-009571-mygj2nd4 2212 47 - - HYPH cord-009571-mygj2nd4 2212 48 DNA).Three dna).three CD cord-009571-mygj2nd4 2212 49 thousand thousand CD cord-009571-mygj2nd4 2212 50 three three CD cord-009571-mygj2nd4 2212 51 hundred hundred CD cord-009571-mygj2nd4 2212 52 thirty thirty CD cord-009571-mygj2nd4 2212 53 - - HYPH cord-009571-mygj2nd4 2212 54 four four CD cord-009571-mygj2nd4 2212 55 sera sera NNP cord-009571-mygj2nd4 2212 56 from from IN cord-009571-mygj2nd4 2212 57 98 98 CD cord-009571-mygj2nd4 2212 58 SLE SLE NNP cord-009571-mygj2nd4 2212 59 patients patient NNS cord-009571-mygj2nd4 2212 60 were be VBD cord-009571-mygj2nd4 2212 61 studied study VBN cord-009571-mygj2nd4 2212 62 . . . cord-009571-mygj2nd4 2213 1 Only only RB cord-009571-mygj2nd4 2213 2 patients patient NNS cord-009571-mygj2nd4 2213 3 observed observe VBN cord-009571-mygj2nd4 2213 4 by by IN cord-009571-mygj2nd4 2213 5 us -PRON- PRP cord-009571-mygj2nd4 2213 6 and and CC cord-009571-mygj2nd4 2213 7 whose whose WP$ cord-009571-mygj2nd4 2213 8 sera sera NNP cord-009571-mygj2nd4 2213 9 were be VBD cord-009571-mygj2nd4 2213 10 tested test VBN cord-009571-mygj2nd4 2213 11 both both CC cord-009571-mygj2nd4 2213 12 during during IN cord-009571-mygj2nd4 2213 13 periods period NNS cord-009571-mygj2nd4 2213 14 of of IN cord-009571-mygj2nd4 2213 15 remission remission NN cord-009571-mygj2nd4 2213 16 and and CC cord-009571-mygj2nd4 2213 17 disease disease NN cord-009571-mygj2nd4 2213 18 activity activity NN cord-009571-mygj2nd4 2213 19 were be VBD cord-009571-mygj2nd4 2213 20 included include VBN cord-009571-mygj2nd4 2213 21 in in IN cord-009571-mygj2nd4 2213 22 this this DT cord-009571-mygj2nd4 2213 23 study study NN cord-009571-mygj2nd4 2213 24 . . . cord-009571-mygj2nd4 2214 1 An an DT cord-009571-mygj2nd4 2214 2 average average NN cord-009571-mygj2nd4 2214 3 of of IN cord-009571-mygj2nd4 2214 4 34 34 CD cord-009571-mygj2nd4 2214 5 serum serum NN cord-009571-mygj2nd4 2214 6 samples sample NNS cord-009571-mygj2nd4 2214 7 per per IN cord-009571-mygj2nd4 2214 8 patient patient NN cord-009571-mygj2nd4 2214 9 was be VBD cord-009571-mygj2nd4 2214 10 studied study VBN cord-009571-mygj2nd4 2214 11 . . . cord-009571-mygj2nd4 2215 1 The the DT cord-009571-mygj2nd4 2215 2 average average JJ cord-009571-mygj2nd4 2215 3 period period NN cord-009571-mygj2nd4 2215 4 of of IN cord-009571-mygj2nd4 2215 5 observation observation NN cord-009571-mygj2nd4 2215 6 was be VBD cord-009571-mygj2nd4 2215 7 38.4 38.4 CD cord-009571-mygj2nd4 2215 8 months month NNS cord-009571-mygj2nd4 2215 9 . . . cord-009571-mygj2nd4 2216 1 Patients patient NNS cord-009571-mygj2nd4 2216 2 had have VBD cord-009571-mygj2nd4 2216 3 at at RB cord-009571-mygj2nd4 2216 4 least least RBS cord-009571-mygj2nd4 2216 5 4 4 CD cord-009571-mygj2nd4 2216 6 of of IN cord-009571-mygj2nd4 2216 7 the the DT cord-009571-mygj2nd4 2216 8 14 14 CD cord-009571-mygj2nd4 2216 9 manifestations manifestation NNS cord-009571-mygj2nd4 2216 10 of of IN cord-009571-mygj2nd4 2216 11 the the DT cord-009571-mygj2nd4 2216 12 ARA ARA NNP cord-009571-mygj2nd4 2216 13 Criteria Criteria NNP cord-009571-mygj2nd4 2216 14 . . . cord-009571-mygj2nd4 2217 1 C3 C3 NNP cord-009571-mygj2nd4 2217 2 levels level NNS cord-009571-mygj2nd4 2217 3 and and CC cord-009571-mygj2nd4 2217 4 a a DT cord-009571-mygj2nd4 2217 5 - - HYPH cord-009571-mygj2nd4 2217 6 DNA dna NN cord-009571-mygj2nd4 2217 7 were be VBD cord-009571-mygj2nd4 2217 8 studied study VBN cord-009571-mygj2nd4 2217 9 from from IN cord-009571-mygj2nd4 2217 10 59 59 CD cord-009571-mygj2nd4 2217 11 normal normal JJ cord-009571-mygj2nd4 2217 12 individuals individual NNS cord-009571-mygj2nd4 2217 13 , , , cord-009571-mygj2nd4 2217 14 118 118 CD cord-009571-mygj2nd4 2217 15 patients patient NNS cord-009571-mygj2nd4 2217 16 with with IN cord-009571-mygj2nd4 2217 17 rheumatoid rheumatoid NN cord-009571-mygj2nd4 2217 18 arthritis arthritis NN cord-009571-mygj2nd4 2217 19 followed follow VBN cord-009571-mygj2nd4 2217 20 by by IN cord-009571-mygj2nd4 2217 21 us -PRON- PRP cord-009571-mygj2nd4 2217 22 , , , cord-009571-mygj2nd4 2217 23 and and CC cord-009571-mygj2nd4 2217 24 from from IN cord-009571-mygj2nd4 2217 25 patients patient NNS cord-009571-mygj2nd4 2217 26 with with IN cord-009571-mygj2nd4 2217 27 other other JJ cord-009571-mygj2nd4 2217 28 diseases disease NNS cord-009571-mygj2nd4 2217 29 . . . cord-009571-mygj2nd4 2218 1 Two two CD cord-009571-mygj2nd4 2218 2 of of IN cord-009571-mygj2nd4 2218 3 the the DT cord-009571-mygj2nd4 2218 4 non non JJ cord-009571-mygj2nd4 2218 5 - - JJ cord-009571-mygj2nd4 2218 6 SLE sle JJ cord-009571-mygj2nd4 2218 7 patients patient NNS cord-009571-mygj2nd4 2218 8 ( ( -LRB- cord-009571-mygj2nd4 2218 9 1 1 CD cord-009571-mygj2nd4 2218 10 % % NN cord-009571-mygj2nd4 2218 11 ) ) -RRB- cord-009571-mygj2nd4 2218 12 had have VBD cord-009571-mygj2nd4 2218 13 a a DT cord-009571-mygj2nd4 2218 14 - - HYPH cord-009571-mygj2nd4 2218 15 DNA dna NN cord-009571-mygj2nd4 2218 16 level level NN cord-009571-mygj2nd4 2218 17 ( ( -LRB- cord-009571-mygj2nd4 2218 18 expressed express VBN cord-009571-mygj2nd4 2218 19 as as IN cord-009571-mygj2nd4 2218 20 % % NN cord-009571-mygj2nd4 2218 21 DNA dna NN cord-009571-mygj2nd4 2218 22 bound bind VBN cord-009571-mygj2nd4 2218 23 ) ) -RRB- cord-009571-mygj2nd4 2218 24 of of IN cord-009571-mygj2nd4 2218 25 more more JJR cord-009571-mygj2nd4 2218 26 than than IN cord-009571-mygj2nd4 2218 27 41 41 CD cord-009571-mygj2nd4 2218 28 % % NN cord-009571-mygj2nd4 2218 29 ( ( -LRB- cord-009571-mygj2nd4 2218 30 46%,52 46%,52 CD cord-009571-mygj2nd4 2218 31 % % NN cord-009571-mygj2nd4 2218 32 ) ) -RRB- cord-009571-mygj2nd4 2218 33 . . . cord-009571-mygj2nd4 2219 1 Thus thus RB cord-009571-mygj2nd4 2219 2 , , , cord-009571-mygj2nd4 2219 3 a a DT cord-009571-mygj2nd4 2219 4 a a DT cord-009571-mygj2nd4 2219 5 - - HYPH cord-009571-mygj2nd4 2219 6 DNA dna NN cord-009571-mygj2nd4 2219 7 of of IN cord-009571-mygj2nd4 2219 8 > > $ cord-009571-mygj2nd4 2219 9 41 41 CD cord-009571-mygj2nd4 2219 10 % % NN cord-009571-mygj2nd4 2219 11 binding binding NN cord-009571-mygj2nd4 2219 12 had have VBD cord-009571-mygj2nd4 2219 13 a a DT cord-009571-mygj2nd4 2219 14 specificity specificity NN cord-009571-mygj2nd4 2219 15 for for IN cord-009571-mygj2nd4 2219 16 SLE SLE NNP cord-009571-mygj2nd4 2219 17 of of IN cord-009571-mygj2nd4 2219 18 99 99 CD cord-009571-mygj2nd4 2219 19 % % NN cord-009571-mygj2nd4 2219 20 . . . cord-009571-mygj2nd4 2220 1 Eighty eighty CD cord-009571-mygj2nd4 2220 2 - - HYPH cord-009571-mygj2nd4 2220 3 two two CD cord-009571-mygj2nd4 2220 4 percent percent NN cord-009571-mygj2nd4 2220 5 of of IN cord-009571-mygj2nd4 2220 6 the the DT cord-009571-mygj2nd4 2220 7 SLE SLE NNP cord-009571-mygj2nd4 2220 8 patients patient NNS cord-009571-mygj2nd4 2220 9 had have VBD cord-009571-mygj2nd4 2220 10 a a DT cord-009571-mygj2nd4 2220 11 - - HYPH cord-009571-mygj2nd4 2220 12 DNA dna NN cord-009571-mygj2nd4 2220 13 of of IN cord-009571-mygj2nd4 2220 14 > > $ cord-009571-mygj2nd4 2220 15 41 41 CD cord-009571-mygj2nd4 2220 16 % % NN cord-009571-mygj2nd4 2220 17 binding bind VBG cord-009571-mygj2nd4 2220 18 as as IN cord-009571-mygj2nd4 2220 19 their -PRON- PRP$ cord-009571-mygj2nd4 2220 20 highest high JJS cord-009571-mygj2nd4 2220 21 value value NN cord-009571-mygj2nd4 2220 22 - - : cord-009571-mygj2nd4 2220 23 a a DT cord-009571-mygj2nd4 2220 24 sensitivity sensitivity NN cord-009571-mygj2nd4 2220 25 of of IN cord-009571-mygj2nd4 2220 26 82 82 CD cord-009571-mygj2nd4 2220 27 % % NN cord-009571-mygj2nd4 2220 28 . . . cord-009571-mygj2nd4 2221 1 None none NN cord-009571-mygj2nd4 2221 2 of of IN cord-009571-mygj2nd4 2221 3 the the DT cord-009571-mygj2nd4 2221 4 non non JJ cord-009571-mygj2nd4 2221 5 - - JJ cord-009571-mygj2nd4 2221 6 SLE sle JJ cord-009571-mygj2nd4 2221 7 patients patient NNS cord-009571-mygj2nd4 2221 8 had have VBD cord-009571-mygj2nd4 2221 9 a a DT cord-009571-mygj2nd4 2221 10 C3 c3 NN cord-009571-mygj2nd4 2221 11 of of IN cord-009571-mygj2nd4 2221 12 < < NNP cord-009571-mygj2nd4 2221 13 71 71 CD cord-009571-mygj2nd4 2221 14 mg%-a mg%-a DT cord-009571-mygj2nd4 2221 15 specificity specificity NN cord-009571-mygj2nd4 2221 16 of of IN cord-009571-mygj2nd4 2221 17 100 100 CD cord-009571-mygj2nd4 2221 18 % % NN cord-009571-mygj2nd4 2221 19 . . . cord-009571-mygj2nd4 2222 1 Fifty fifty CD cord-009571-mygj2nd4 2222 2 - - HYPH cord-009571-mygj2nd4 2222 3 five five CD cord-009571-mygj2nd4 2222 4 percent percent NN cord-009571-mygj2nd4 2222 5 of of IN cord-009571-mygj2nd4 2222 6 the the DT cord-009571-mygj2nd4 2222 7 SLE SLE NNP cord-009571-mygj2nd4 2222 8 patients patient NNS cord-009571-mygj2nd4 2222 9 had have VBD cord-009571-mygj2nd4 2222 10 a a DT cord-009571-mygj2nd4 2222 11 C3 c3 JJ cord-009571-mygj2nd4 2222 12 level level NN cord-009571-mygj2nd4 2222 13 of of IN cord-009571-mygj2nd4 2222 14 < < NNP cord-009571-mygj2nd4 2222 15 7 7 CD cord-009571-mygj2nd4 2222 16 1 1 CD cord-009571-mygj2nd4 2222 17 mg% mg% CD cord-009571-mygj2nd4 2222 18 as as IN cord-009571-mygj2nd4 2222 19 their -PRON- PRP$ cord-009571-mygj2nd4 2222 20 lowest low JJS cord-009571-mygj2nd4 2222 21 C3-a c3-a NN cord-009571-mygj2nd4 2222 22 sensitivity sensitivity NN cord-009571-mygj2nd4 2222 23 of of IN cord-009571-mygj2nd4 2222 24 54%.These 54%.These NNP cord-009571-mygj2nd4 2222 25 data datum NNS cord-009571-mygj2nd4 2222 26 were be VBD cord-009571-mygj2nd4 2222 27 analyzed analyze VBN cord-009571-mygj2nd4 2222 28 using use VBG cord-009571-mygj2nd4 2222 29 the the DT cord-009571-mygj2nd4 2222 30 method method NN cord-009571-mygj2nd4 2222 31 employed employ VBN cord-009571-mygj2nd4 2222 32 to to TO cord-009571-mygj2nd4 2222 33 select select VB cord-009571-mygj2nd4 2222 34 the the DT cord-009571-mygj2nd4 2222 35 14 14 CD cord-009571-mygj2nd4 2222 36 manifestations manifestation NNS cord-009571-mygj2nd4 2222 37 of of IN cord-009571-mygj2nd4 2222 38 the the DT cord-009571-mygj2nd4 2222 39 ARA ARA NNP cord-009571-mygj2nd4 2222 40 Criteria Criteria NNP cord-009571-mygj2nd4 2222 41 . . . cord-009571-mygj2nd4 2223 1 The the DT cord-009571-mygj2nd4 2223 2 average average JJ cord-009571-mygj2nd4 2223 3 rate rate NN cord-009571-mygj2nd4 2223 4 of of IN cord-009571-mygj2nd4 2223 5 correct correct JJ cord-009571-mygj2nd4 2223 6 classification classification NN cord-009571-mygj2nd4 2223 7 ( ( -LRB- cord-009571-mygj2nd4 2223 8 the the DT cord-009571-mygj2nd4 2223 9 arithmetic arithmetic JJ cord-009571-mygj2nd4 2223 10 mean mean NN cord-009571-mygj2nd4 2223 11 of of IN cord-009571-mygj2nd4 2223 12 the the DT cord-009571-mygj2nd4 2223 13 sensitivity sensitivity NN cord-009571-mygj2nd4 2223 14 and and CC cord-009571-mygj2nd4 2223 15 specificity specificity NN cord-009571-mygj2nd4 2223 16 ) ) -RRB- cord-009571-mygj2nd4 2223 17 ( ( -LRB- cord-009571-mygj2nd4 2223 18 ARCC ARCC NNP cord-009571-mygj2nd4 2223 19 ) ) -RRB- cord-009571-mygj2nd4 2223 20 for for IN cord-009571-mygj2nd4 2223 21 a a DT cord-009571-mygj2nd4 2223 22 - - HYPH cord-009571-mygj2nd4 2223 23 DNA dna NN cord-009571-mygj2nd4 2223 24 of of IN cord-009571-mygj2nd4 2223 25 > > $ cord-009571-mygj2nd4 2223 26 41 41 CD cord-009571-mygj2nd4 2223 27 % % NN cord-009571-mygj2nd4 2223 28 binding binding NN cord-009571-mygj2nd4 2223 29 is be VBZ cord-009571-mygj2nd4 2223 30 90.5 90.5 CD cord-009571-mygj2nd4 2223 31 and and CC cord-009571-mygj2nd4 2223 32 for for IN cord-009571-mygj2nd4 2223 33 C3 C3 NNP cord-009571-mygj2nd4 2223 34 of of IN cord-009571-mygj2nd4 2223 35 < < XX cord-009571-mygj2nd4 2223 36 71 71 CD cord-009571-mygj2nd4 2224 1 mg% mg% NNP cord-009571-mygj2nd4 2224 2 is be VBZ cord-009571-mygj2nd4 2224 3 77 77 CD cord-009571-mygj2nd4 2224 4 . . . cord-009571-mygj2nd4 2225 1 The the DT cord-009571-mygj2nd4 2225 2 ARCC ARCC NNP cord-009571-mygj2nd4 2225 3 for for IN cord-009571-mygj2nd4 2225 4 the the DT cord-009571-mygj2nd4 2225 5 22 22 CD cord-009571-mygj2nd4 2225 6 items item NNS cord-009571-mygj2nd4 2225 7 which which WDT cord-009571-mygj2nd4 2225 8 comprise comprise VBP cord-009571-mygj2nd4 2225 9 the the DT cord-009571-mygj2nd4 2225 10 14 14 CD cord-009571-mygj2nd4 2225 11 manifestations manifestation NNS cord-009571-mygj2nd4 2225 12 of of IN cord-009571-mygj2nd4 2225 13 the the DT cord-009571-mygj2nd4 2225 14 ARA ARA NNP cord-009571-mygj2nd4 2225 15 Criteria Criteria NNP cord-009571-mygj2nd4 2225 16 varied varied JJ cord-009571-mygj2nd4 2225 17 from from IN cord-009571-mygj2nd4 2225 18 52.0 52.0 CD cord-009571-mygj2nd4 2225 19 to to IN cord-009571-mygj2nd4 2225 20 94.9 94.9 CD cord-009571-mygj2nd4 2225 21 . . . cord-009571-mygj2nd4 2226 1 Of of IN cord-009571-mygj2nd4 2226 2 these these DT cord-009571-mygj2nd4 2226 3 , , , cord-009571-mygj2nd4 2226 4 only only RB cord-009571-mygj2nd4 2226 5 the the DT cord-009571-mygj2nd4 2226 6 presence presence NN cord-009571-mygj2nd4 2226 7 of of IN cord-009571-mygj2nd4 2226 8 LE LE NNP cord-009571-mygj2nd4 2226 9 cells cell NNS cord-009571-mygj2nd4 2226 10 had have VBD cord-009571-mygj2nd4 2226 11 a a DT cord-009571-mygj2nd4 2226 12 ARCC arcc NN cord-009571-mygj2nd4 2226 13 greater great JJR cord-009571-mygj2nd4 2226 14 than than IN cord-009571-mygj2nd4 2226 15 that that DT cord-009571-mygj2nd4 2226 16 for for IN cord-009571-mygj2nd4 2226 17 a a DT cord-009571-mygj2nd4 2226 18 - - HYPH cord-009571-mygj2nd4 2226 19 DNA dna NN cord-009571-mygj2nd4 2226 20 . . . cord-009571-mygj2nd4 2227 1 If if IN cord-009571-mygj2nd4 2227 2 C3 c3 NN cord-009571-mygj2nd4 2227 3 and and CC cord-009571-mygj2nd4 2227 4 a a DT cord-009571-mygj2nd4 2227 5 - - HYPH cord-009571-mygj2nd4 2227 6 DNA dna NN cord-009571-mygj2nd4 2227 7 data datum NNS cord-009571-mygj2nd4 2227 8 had have VBD cord-009571-mygj2nd4 2227 9 been be VBN cord-009571-mygj2nd4 2227 10 available available JJ cord-009571-mygj2nd4 2227 11 at at IN cord-009571-mygj2nd4 2227 12 the the DT cord-009571-mygj2nd4 2227 13 time time NN cord-009571-mygj2nd4 2227 14 the the DT cord-009571-mygj2nd4 2227 15 ARA ARA NNP cord-009571-mygj2nd4 2227 16 Criteria Criteria NNP cord-009571-mygj2nd4 2227 17 were be VBD cord-009571-mygj2nd4 2227 18 developed develop VBN cord-009571-mygj2nd4 2227 19 , , , cord-009571-mygj2nd4 2227 20 they -PRON- PRP cord-009571-mygj2nd4 2227 21 would would MD cord-009571-mygj2nd4 2227 22 have have VB cord-009571-mygj2nd4 2227 23 been be VBN cord-009571-mygj2nd4 2227 24 included include VBN cord-009571-mygj2nd4 2227 25 . . . cord-009571-mygj2nd4 2228 1 The the DT cord-009571-mygj2nd4 2228 2 ARCC ARCC NNP cord-009571-mygj2nd4 2228 3 for for IN cord-009571-mygj2nd4 2228 4 the the DT cord-009571-mygj2nd4 2228 5 mean mean NN cord-009571-mygj2nd4 2228 6 of of IN cord-009571-mygj2nd4 2228 7 the the DT cord-009571-mygj2nd4 2228 8 2 2 CD cord-009571-mygj2nd4 2228 9 items item NNS cord-009571-mygj2nd4 2228 10 combined combine VBN cord-009571-mygj2nd4 2228 11 for for IN cord-009571-mygj2nd4 2228 12 the the DT cord-009571-mygj2nd4 2228 13 CNS CNS NNP cord-009571-mygj2nd4 2228 14 manifestations manifestation NNS cord-009571-mygj2nd4 2228 15 and and CC cord-009571-mygj2nd4 2228 16 the the DT cord-009571-mygj2nd4 2228 17 ARCC ARCC NNP cord-009571-mygj2nd4 2228 18 for for IN cord-009571-mygj2nd4 2228 19 the the DT cord-009571-mygj2nd4 2228 20 mean mean NN cord-009571-mygj2nd4 2228 21 of of IN cord-009571-mygj2nd4 2228 22 the the DT cord-009571-mygj2nd4 2228 23 hematologic hematologic JJ cord-009571-mygj2nd4 2228 24 items item NNS cord-009571-mygj2nd4 2228 25 were be VBD cord-009571-mygj2nd4 2228 26 lower low JJR cord-009571-mygj2nd4 2228 27 than than IN cord-009571-mygj2nd4 2228 28 those those DT cord-009571-mygj2nd4 2228 29 for for IN cord-009571-mygj2nd4 2228 30 either either CC cord-009571-mygj2nd4 2228 31 C3 c3 NN cord-009571-mygj2nd4 2228 32 or or CC cord-009571-mygj2nd4 2228 33 a a DT cord-009571-mygj2nd4 2228 34 - - HYPH cord-009571-mygj2nd4 2228 35 DNA dna NN cord-009571-mygj2nd4 2228 36 . . . cord-009571-mygj2nd4 2229 1 Thus thus RB cord-009571-mygj2nd4 2229 2 , , , cord-009571-mygj2nd4 2229 3 the the DT cord-009571-mygj2nd4 2229 4 C3 c3 NN cord-009571-mygj2nd4 2229 5 and and CC cord-009571-mygj2nd4 2229 6 the the DT cord-009571-mygj2nd4 2229 7 a a DT cord-009571-mygj2nd4 2229 8 - - HYPH cord-009571-mygj2nd4 2229 9 DNA dna NN cord-009571-mygj2nd4 2229 10 could could MD cord-009571-mygj2nd4 2229 11 replace replace VB cord-009571-mygj2nd4 2229 12 these these DT cord-009571-mygj2nd4 2229 13 2 2 CD cord-009571-mygj2nd4 2229 14 manifestations manifestation NNS cord-009571-mygj2nd4 2229 15 . . . cord-009571-mygj2nd4 2230 1 The the DT cord-009571-mygj2nd4 2230 2 data datum NNS cord-009571-mygj2nd4 2230 3 suggest suggest VBP cord-009571-mygj2nd4 2230 4 that that IN cord-009571-mygj2nd4 2230 5 the the DT cord-009571-mygj2nd4 2230 6 ARA ARA NNP cord-009571-mygj2nd4 2230 7 Criteria Criteria NNP cord-009571-mygj2nd4 2230 8 should should MD cord-009571-mygj2nd4 2230 9 be be VB cord-009571-mygj2nd4 2230 10 revised revise VBN cord-009571-mygj2nd4 2230 11 . . . cord-009571-mygj2nd4 2231 1 The the DT cord-009571-mygj2nd4 2231 2 significance significance NN cord-009571-mygj2nd4 2231 3 of of IN cord-009571-mygj2nd4 2231 4 ischemic ischemic JJ cord-009571-mygj2nd4 2231 5 necrosis necrosis NN cord-009571-mygj2nd4 2231 6 of of IN cord-009571-mygj2nd4 2231 7 bone bone NN cord-009571-mygj2nd4 2231 8 ( ( -LRB- cord-009571-mygj2nd4 2231 9 INB INB NNP cord-009571-mygj2nd4 2231 10 ) ) -RRB- cord-009571-mygj2nd4 2231 11 in in IN cord-009571-mygj2nd4 2231 12 SLE SLE NNP cord-009571-mygj2nd4 2231 13 and and CC cord-009571-mygj2nd4 2231 14 the the DT cord-009571-mygj2nd4 2231 15 cause cause NN cord-009571-mygj2nd4 2231 16 of of IN cord-009571-mygj2nd4 2231 17 the the DT cord-009571-mygj2nd4 2231 18 bony bony JJ cord-009571-mygj2nd4 2231 19 lesion lesion NN cord-009571-mygj2nd4 2231 20 are be VBP cord-009571-mygj2nd4 2231 21 not not RB cord-009571-mygj2nd4 2231 22 established establish VBN cord-009571-mygj2nd4 2231 23 . . . cord-009571-mygj2nd4 2232 1 In in IN cord-009571-mygj2nd4 2232 2 this this DT cord-009571-mygj2nd4 2232 3 study study NN cord-009571-mygj2nd4 2232 4 , , , cord-009571-mygj2nd4 2232 5 36 36 CD cord-009571-mygj2nd4 2232 6 patients patient NNS cord-009571-mygj2nd4 2232 7 with with IN cord-009571-mygj2nd4 2232 8 SLE SLE NNP cord-009571-mygj2nd4 2232 9 and and CC cord-009571-mygj2nd4 2232 10 INB INB NNP cord-009571-mygj2nd4 2232 11 have have VBP cord-009571-mygj2nd4 2232 12 been be VBN cord-009571-mygj2nd4 2232 13 compared compare VBN cord-009571-mygj2nd4 2232 14 to to IN cord-009571-mygj2nd4 2232 15 124 124 CD cord-009571-mygj2nd4 2232 16 patients patient NNS cord-009571-mygj2nd4 2232 17 with with IN cord-009571-mygj2nd4 2232 18 SLE SLE NNP cord-009571-mygj2nd4 2232 19 alone alone RB cord-009571-mygj2nd4 2232 20 ; ; : cord-009571-mygj2nd4 2232 21 and and CC cord-009571-mygj2nd4 2232 22 , , , cord-009571-mygj2nd4 2232 23 in in IN cord-009571-mygj2nd4 2232 24 those those DT cord-009571-mygj2nd4 2232 25 with with IN cord-009571-mygj2nd4 2232 26 INB INB NNP cord-009571-mygj2nd4 2232 27 , , , cord-009571-mygj2nd4 2232 28 the the DT cord-009571-mygj2nd4 2232 29 cause cause NN cord-009571-mygj2nd4 2232 30 of of IN cord-009571-mygj2nd4 2232 31 the the DT cord-009571-mygj2nd4 2232 32 osseous osseous JJ cord-009571-mygj2nd4 2232 33 lesion lesion NN cord-009571-mygj2nd4 2232 34 has have VBZ cord-009571-mygj2nd4 2232 35 been be VBN cord-009571-mygj2nd4 2232 36 analyzed analyze VBN cord-009571-mygj2nd4 2232 37 in in IN cord-009571-mygj2nd4 2232 38 relation relation NN cord-009571-mygj2nd4 2232 39 to to IN cord-009571-mygj2nd4 2232 40 medical medical JJ cord-009571-mygj2nd4 2232 41 versus versus IN cord-009571-mygj2nd4 2232 42 surgical surgical JJ cord-009571-mygj2nd4 2232 43 management management NN cord-009571-mygj2nd4 2232 44 . . . cord-009571-mygj2nd4 2233 1 Those those DT cord-009571-mygj2nd4 2233 2 clinical clinical JJ cord-009571-mygj2nd4 2233 3 features feature NNS cord-009571-mygj2nd4 2233 4 of of IN cord-009571-mygj2nd4 2233 5 SLE SLE NNP cord-009571-mygj2nd4 2233 6 significantly significantly RB cord-009571-mygj2nd4 2233 7 correlated correlate VBD cord-009571-mygj2nd4 2233 8 with with IN cord-009571-mygj2nd4 2233 9 INB INB NNP cord-009571-mygj2nd4 2233 10 include include VBP cord-009571-mygj2nd4 2233 11 Raynaud Raynaud NNP cord-009571-mygj2nd4 2233 12 's 's POS cord-009571-mygj2nd4 2233 13 phenomenon phenomenon NN cord-009571-mygj2nd4 2233 14 ( ( -LRB- cord-009571-mygj2nd4 2233 15 61 61 CD cord-009571-mygj2nd4 2233 16 % % NN cord-009571-mygj2nd4 2233 17 versus versus IN cord-009571-mygj2nd4 2233 18 13 13 CD cord-009571-mygj2nd4 2233 19 % % NN cord-009571-mygj2nd4 2233 20 , , , cord-009571-mygj2nd4 2233 21 P p NN cord-009571-mygj2nd4 2233 22 < < XX cord-009571-mygj2nd4 2233 23 O.OOl o.ool XX cord-009571-mygj2nd4 2233 24 ) ) -RRB- cord-009571-mygj2nd4 2233 25 , , , cord-009571-mygj2nd4 2233 26 myositis myositis NN cord-009571-mygj2nd4 2233 27 ( ( -LRB- cord-009571-mygj2nd4 2233 28 25 25 CD cord-009571-mygj2nd4 2233 29 % % NN cord-009571-mygj2nd4 2233 30 versus versus IN cord-009571-mygj2nd4 2233 31 7 7 CD cord-009571-mygj2nd4 2233 32 % % NN cord-009571-mygj2nd4 2233 33 , , , cord-009571-mygj2nd4 2233 34 P p NN cord-009571-mygj2nd4 2233 35 < < XX cord-009571-mygj2nd4 2233 36 O.Ol O.Ol NNP cord-009571-mygj2nd4 2233 37 ) ) -RRB- cord-009571-mygj2nd4 2233 38 , , , cord-009571-mygj2nd4 2233 39 and and CC cord-009571-mygj2nd4 2233 40 vasculitis vasculitis NN cord-009571-mygj2nd4 2233 41 ( ( -LRB- cord-009571-mygj2nd4 2233 42 50 50 CD cord-009571-mygj2nd4 2233 43 % % NN cord-009571-mygj2nd4 2233 44 versus versus IN cord-009571-mygj2nd4 2233 45 26 26 CD cord-009571-mygj2nd4 2233 46 % % NN cord-009571-mygj2nd4 2233 47 , , , cord-009571-mygj2nd4 2233 48 P p NN cord-009571-mygj2nd4 2233 49 < < XX cord-009571-mygj2nd4 2233 50 0.025 0.025 CD cord-009571-mygj2nd4 2233 51 ) ) -RRB- cord-009571-mygj2nd4 2233 52 . . . cord-009571-mygj2nd4 2234 1 The the DT cord-009571-mygj2nd4 2234 2 course course NN cord-009571-mygj2nd4 2234 3 of of IN cord-009571-mygj2nd4 2234 4 73 73 CD cord-009571-mygj2nd4 2234 5 INB INB NNP cord-009571-mygj2nd4 2234 6 sites site NNS cord-009571-mygj2nd4 2234 7 in in IN cord-009571-mygj2nd4 2234 8 the the DT cord-009571-mygj2nd4 2234 9 36 36 CD cord-009571-mygj2nd4 2234 10 patients patient NNS cord-009571-mygj2nd4 2234 11 initially initially RB cord-009571-mygj2nd4 2234 12 grouped group VBD cord-009571-mygj2nd4 2234 13 into into IN cord-009571-mygj2nd4 2234 14 medical medical JJ cord-009571-mygj2nd4 2234 15 ( ( -LRB- cord-009571-mygj2nd4 2234 16 20 20 CD cord-009571-mygj2nd4 2234 17 patients patient NNS cord-009571-mygj2nd4 2234 18 ; ; : cord-009571-mygj2nd4 2234 19 41 41 CD cord-009571-mygj2nd4 2234 20 sites site NNS cord-009571-mygj2nd4 2234 21 ) ) -RRB- cord-009571-mygj2nd4 2234 22 and and CC cord-009571-mygj2nd4 2234 23 surgical surgical JJ cord-009571-mygj2nd4 2234 24 ( ( -LRB- cord-009571-mygj2nd4 2234 25 I6 i6 CD cord-009571-mygj2nd4 2234 26 patients patient NNS cord-009571-mygj2nd4 2234 27 ; ; : cord-009571-mygj2nd4 2234 28 32 32 CD cord-009571-mygj2nd4 2234 29 sites site NNS cord-009571-mygj2nd4 2234 30 ) ) -RRB- cord-009571-mygj2nd4 2234 31 is be VBZ cord-009571-mygj2nd4 2234 32 shown show VBN cord-009571-mygj2nd4 2234 33 in in IN cord-009571-mygj2nd4 2234 34 the the DT cord-009571-mygj2nd4 2234 35 table table NN cord-009571-mygj2nd4 2234 36 . . . cord-009571-mygj2nd4 2235 1 The the DT cord-009571-mygj2nd4 2235 2 initial initial JJ cord-009571-mygj2nd4 2235 3 orthopedic orthopedic NN cord-009571-mygj2nd4 2235 4 procedure procedure NN cord-009571-mygj2nd4 2235 5 was be VBD cord-009571-mygj2nd4 2235 6 uniformly uniformly RB cord-009571-mygj2nd4 2235 7 core core NN cord-009571-mygj2nd4 2235 8 decompression decompression NN cord-009571-mygj2nd4 2235 9 . . . cord-009571-mygj2nd4 2236 1 All all DT cord-009571-mygj2nd4 2236 2 patients patient NNS cord-009571-mygj2nd4 2236 3 were be VBD cord-009571-mygj2nd4 2236 4 receiving receive VBG cord-009571-mygj2nd4 2236 5 corticosteroids corticosteroid NNS cord-009571-mygj2nd4 2236 6 . . . cord-009571-mygj2nd4 2237 1 The the DT cord-009571-mygj2nd4 2237 2 failure failure NN cord-009571-mygj2nd4 2237 3 of of IN cord-009571-mygj2nd4 2237 4 medical medical JJ cord-009571-mygj2nd4 2237 5 management management NN cord-009571-mygj2nd4 2237 6 alone alone RB cord-009571-mygj2nd4 2237 7 is be VBZ cord-009571-mygj2nd4 2237 8 shown show VBN cord-009571-mygj2nd4 2237 9 by by IN cord-009571-mygj2nd4 2237 10 the the DT cord-009571-mygj2nd4 2237 11 persistence persistence NN cord-009571-mygj2nd4 2237 12 of of IN cord-009571-mygj2nd4 2237 13 symptoms symptom NNS cord-009571-mygj2nd4 2237 14 ( ( -LRB- cord-009571-mygj2nd4 2237 15 39 39 CD cord-009571-mygj2nd4 2237 16 or or CC cord-009571-mygj2nd4 2237 17 95 95 CD cord-009571-mygj2nd4 2237 18 % % NN cord-009571-mygj2nd4 2237 19 ) ) -RRB- cord-009571-mygj2nd4 2237 20 , , , cord-009571-mygj2nd4 2237 21 x x NN cord-009571-mygj2nd4 2237 22 - - NN cord-009571-mygj2nd4 2237 23 ray ray JJ cord-009571-mygj2nd4 2237 24 progression progression NN cord-009571-mygj2nd4 2237 25 ( ( -LRB- cord-009571-mygj2nd4 2237 26 35 35 CD cord-009571-mygj2nd4 2237 27 or or CC cord-009571-mygj2nd4 2237 28 85 85 CD cord-009571-mygj2nd4 2237 29 % % NN cord-009571-mygj2nd4 2237 30 ) ) -RRB- cord-009571-mygj2nd4 2237 31 , , , cord-009571-mygj2nd4 2237 32 and and CC cord-009571-mygj2nd4 2237 33 need need VB cord-009571-mygj2nd4 2237 34 for for IN cord-009571-mygj2nd4 2237 35 reconstructive reconstructive JJ cord-009571-mygj2nd4 2237 36 surgery surgery NN cord-009571-mygj2nd4 2237 37 ( ( -LRB- cord-009571-mygj2nd4 2237 38 22 22 CD cord-009571-mygj2nd4 2237 39 or or CC cord-009571-mygj2nd4 2237 40 53 53 CD cord-009571-mygj2nd4 2237 41 % % NN cord-009571-mygj2nd4 2237 42 ) ) -RRB- cord-009571-mygj2nd4 2237 43 . . . cord-009571-mygj2nd4 2238 1 In in IN cord-009571-mygj2nd4 2238 2 stages stage NNS cord-009571-mygj2nd4 2238 3 I1 i1 NN cord-009571-mygj2nd4 2238 4 and and CC cord-009571-mygj2nd4 2238 5 111 111 CD cord-009571-mygj2nd4 2238 6 of of IN cord-009571-mygj2nd4 2238 7 the the DT cord-009571-mygj2nd4 2238 8 surgical surgical JJ cord-009571-mygj2nd4 2238 9 group group NN cord-009571-mygj2nd4 2238 10 , , , cord-009571-mygj2nd4 2238 11 only only RB cord-009571-mygj2nd4 2238 12 7 7 CD cord-009571-mygj2nd4 2238 13 sites site NNS cord-009571-mygj2nd4 2238 14 ( ( -LRB- cord-009571-mygj2nd4 2238 15 25 25 CD cord-009571-mygj2nd4 2238 16 % % NN cord-009571-mygj2nd4 2238 17 ) ) -RRB- cord-009571-mygj2nd4 2238 18 were be VBD cord-009571-mygj2nd4 2238 19 symptomatic symptomatic JJ cord-009571-mygj2nd4 2238 20 , , , cord-009571-mygj2nd4 2238 21 5 5 CD cord-009571-mygj2nd4 2238 22 sites site NNS cord-009571-mygj2nd4 2238 23 ( ( -LRB- cord-009571-mygj2nd4 2238 24 17 17 CD cord-009571-mygj2nd4 2238 25 % % NN cord-009571-mygj2nd4 2238 26 ) ) -RRB- cord-009571-mygj2nd4 2238 27 progressed progress VBD cord-009571-mygj2nd4 2238 28 on on IN cord-009571-mygj2nd4 2238 29 x x NN cord-009571-mygj2nd4 2238 30 - - NN cord-009571-mygj2nd4 2238 31 ray ray NN cord-009571-mygj2nd4 2238 32 , , , cord-009571-mygj2nd4 2238 33 and and CC cord-009571-mygj2nd4 2238 34 only only RB cord-009571-mygj2nd4 2238 35 3 3 CD cord-009571-mygj2nd4 2238 36 ( ( -LRB- cord-009571-mygj2nd4 2238 37 10 10 CD cord-009571-mygj2nd4 2238 38 % % NN cord-009571-mygj2nd4 2238 39 ) ) -RRB- cord-009571-mygj2nd4 2238 40 required require VBN cord-009571-mygj2nd4 2238 41 further further JJ cord-009571-mygj2nd4 2238 42 surgery surgery NN cord-009571-mygj2nd4 2238 43 . . . cord-009571-mygj2nd4 2239 1 None none NN cord-009571-mygj2nd4 2239 2 in in IN cord-009571-mygj2nd4 2239 3 stage stage NN cord-009571-mygj2nd4 2239 4 I -PRON- PRP cord-009571-mygj2nd4 2239 5 advanced advance VBD cord-009571-mygj2nd4 2239 6 . . . cord-009571-mygj2nd4 2240 1 Differences difference NNS cord-009571-mygj2nd4 2240 2 in in IN cord-009571-mygj2nd4 2240 3 followup followup JJ cord-009571-mygj2nd4 2240 4 intervals interval NNS cord-009571-mygj2nd4 2240 5 would would MD cord-009571-mygj2nd4 2240 6 not not RB cord-009571-mygj2nd4 2240 7 appear appear VB cord-009571-mygj2nd4 2240 8 to to TO cord-009571-mygj2nd4 2240 9 explain explain VB cord-009571-mygj2nd4 2240 10 these these DT cord-009571-mygj2nd4 2240 11 statistically statistically RB cord-009571-mygj2nd4 2240 12 significant significant JJ cord-009571-mygj2nd4 2240 13 differences difference NNS cord-009571-mygj2nd4 2240 14 . . . cord-009571-mygj2nd4 2241 1 Thus thus RB cord-009571-mygj2nd4 2241 2 , , , cord-009571-mygj2nd4 2241 3 in in IN cord-009571-mygj2nd4 2241 4 the the DT cord-009571-mygj2nd4 2241 5 steroid steroid NN cord-009571-mygj2nd4 2241 6 - - HYPH cord-009571-mygj2nd4 2241 7 treated treat VBN cord-009571-mygj2nd4 2241 8 SLE SLE NNP cord-009571-mygj2nd4 2241 9 patient patient NN cord-009571-mygj2nd4 2241 10 , , , cord-009571-mygj2nd4 2241 11 especially especially RB cord-009571-mygj2nd4 2241 12 with with IN cord-009571-mygj2nd4 2241 13 Raynaud Raynaud NNP cord-009571-mygj2nd4 2241 14 's 's POS cord-009571-mygj2nd4 2241 15 , , , cord-009571-mygj2nd4 2241 16 myositis myositis NN cord-009571-mygj2nd4 2241 17 , , , cord-009571-mygj2nd4 2241 18 and/or and/or CC cord-009571-mygj2nd4 2241 19 vasculitis vasculitis NN cord-009571-mygj2nd4 2241 20 , , , cord-009571-mygj2nd4 2241 21 the the DT cord-009571-mygj2nd4 2241 22 risk risk NN cord-009571-mygj2nd4 2241 23 of of IN cord-009571-mygj2nd4 2241 24 INB INB NNP cord-009571-mygj2nd4 2241 25 is be VBZ cord-009571-mygj2nd4 2241 26 major major JJ cord-009571-mygj2nd4 2241 27 and and CC cord-009571-mygj2nd4 2241 28 the the DT cord-009571-mygj2nd4 2241 29 need need NN cord-009571-mygj2nd4 2241 30 for for IN cord-009571-mygj2nd4 2241 31 early early JJ cord-009571-mygj2nd4 2241 32 diagnosis diagnosis NN cord-009571-mygj2nd4 2241 33 essential essential JJ cord-009571-mygj2nd4 2241 34 if if IN cord-009571-mygj2nd4 2241 35 progression progression NN cord-009571-mygj2nd4 2241 36 of of IN cord-009571-mygj2nd4 2241 37 the the DT cord-009571-mygj2nd4 2241 38 bony bony JJ cord-009571-mygj2nd4 2241 39 lesion lesion NN cord-009571-mygj2nd4 2241 40 is be VBZ cord-009571-mygj2nd4 2241 41 to to TO cord-009571-mygj2nd4 2241 42 be be VB cord-009571-mygj2nd4 2241 43 retarded retard VBN cord-009571-mygj2nd4 2241 44 by by IN cord-009571-mygj2nd4 2241 45 orthopedic orthopedic NN cord-009571-mygj2nd4 2241 46 intervention intervention NN cord-009571-mygj2nd4 2241 47 . . . cord-009571-mygj2nd4 2241 48 _SP cord-009571-mygj2nd4 2242 1 Acute acute JJ cord-009571-mygj2nd4 2242 2 abdominal abdominal JJ cord-009571-mygj2nd4 2242 3 syndromes syndrome NNS cord-009571-mygj2nd4 2242 4 have have VBP cord-009571-mygj2nd4 2242 5 been be VBN cord-009571-mygj2nd4 2242 6 increasingly increasingly RB cord-009571-mygj2nd4 2242 7 recognized recognize VBN cord-009571-mygj2nd4 2242 8 as as IN cord-009571-mygj2nd4 2242 9 major major JJ cord-009571-mygj2nd4 2242 10 life life NN cord-009571-mygj2nd4 2242 11 - - HYPH cord-009571-mygj2nd4 2242 12 threatening threaten VBG cord-009571-mygj2nd4 2242 13 events event NNS cord-009571-mygj2nd4 2242 14 in in IN cord-009571-mygj2nd4 2242 15 patients patient NNS cord-009571-mygj2nd4 2242 16 with with IN cord-009571-mygj2nd4 2242 17 rheumatic rheumatic JJ cord-009571-mygj2nd4 2242 18 disease disease NN cord-009571-mygj2nd4 2242 19 . . . cord-009571-mygj2nd4 2243 1 Early early JJ cord-009571-mygj2nd4 2243 2 diagnosis diagnosis NN cord-009571-mygj2nd4 2243 3 is be VBZ cord-009571-mygj2nd4 2243 4 critical critical JJ cord-009571-mygj2nd4 2243 5 to to IN cord-009571-mygj2nd4 2243 6 the the DT cord-009571-mygj2nd4 2243 7 institution institution NN cord-009571-mygj2nd4 2243 8 of of IN cord-009571-mygj2nd4 2243 9 appropriate appropriate JJ cord-009571-mygj2nd4 2243 10 medical medical JJ cord-009571-mygj2nd4 2243 11 / / SYM cord-009571-mygj2nd4 2243 12 surgical surgical JJ cord-009571-mygj2nd4 2243 13 management management NN cord-009571-mygj2nd4 2243 14 and and CC cord-009571-mygj2nd4 2243 15 may may MD cord-009571-mygj2nd4 2243 16 be be VB cord-009571-mygj2nd4 2243 17 impeded impede VBN cord-009571-mygj2nd4 2243 18 by by IN cord-009571-mygj2nd4 2243 19 the the DT cord-009571-mygj2nd4 2243 20 masking mask VBG cord-009571-mygj2nd4 2243 21 effects effect NNS cord-009571-mygj2nd4 2243 22 of of IN cord-009571-mygj2nd4 2243 23 antiinflammatory antiinflammatory JJ cord-009571-mygj2nd4 2243 24 , , , cord-009571-mygj2nd4 2243 25 especially especially RB cord-009571-mygj2nd4 2243 26 steroidal steroidal JJ cord-009571-mygj2nd4 2243 27 , , , cord-009571-mygj2nd4 2243 28 therapy therapy NN cord-009571-mygj2nd4 2243 29 . . . cord-009571-mygj2nd4 2244 1 It -PRON- PRP cord-009571-mygj2nd4 2244 2 is be VBZ cord-009571-mygj2nd4 2244 3 our -PRON- PRP$ cord-009571-mygj2nd4 2244 4 purpose purpose NN cord-009571-mygj2nd4 2244 5 here here RB cord-009571-mygj2nd4 2244 6 to to TO cord-009571-mygj2nd4 2244 7 report report VB cord-009571-mygj2nd4 2244 8 those those DT cord-009571-mygj2nd4 2244 9 features feature NNS cord-009571-mygj2nd4 2244 10 , , , cord-009571-mygj2nd4 2244 11 clinical clinical JJ cord-009571-mygj2nd4 2244 12 and and CC cord-009571-mygj2nd4 2244 13 laboratory laboratory NN cord-009571-mygj2nd4 2244 14 , , , cord-009571-mygj2nd4 2244 15 which which WDT cord-009571-mygj2nd4 2244 16 appear appear VBP cord-009571-mygj2nd4 2244 17 to to TO cord-009571-mygj2nd4 2244 18 relate relate VB cord-009571-mygj2nd4 2244 19 specifically specifically RB cord-009571-mygj2nd4 2244 20 to to IN cord-009571-mygj2nd4 2244 21 intraabdominal intraabdominal JJ cord-009571-mygj2nd4 2244 22 arteritis arteritis NN cord-009571-mygj2nd4 2244 23 , , , cord-009571-mygj2nd4 2244 24 our -PRON- PRP$ cord-009571-mygj2nd4 2244 25 major major JJ cord-009571-mygj2nd4 2244 26 cause cause NN cord-009571-mygj2nd4 2244 27 of of IN cord-009571-mygj2nd4 2244 28 an an DT cord-009571-mygj2nd4 2244 29 acute acute JJ cord-009571-mygj2nd4 2244 30 abdomen abdomen NN cord-009571-mygj2nd4 2244 31 in in IN cord-009571-mygj2nd4 2244 32 those those DT cord-009571-mygj2nd4 2244 33 with with IN cord-009571-mygj2nd4 2244 34 systemic systemic JJ cord-009571-mygj2nd4 2244 35 lupus lupus NN cord-009571-mygj2nd4 2244 36 erythematosus erythematosus NN cord-009571-mygj2nd4 2244 37 ( ( -LRB- cord-009571-mygj2nd4 2244 38 SLE SLE NNP cord-009571-mygj2nd4 2244 39 ) ) -RRB- cord-009571-mygj2nd4 2244 40 and and CC cord-009571-mygj2nd4 2244 41 polyarteritis polyarteritis NNP cord-009571-mygj2nd4 2244 42 ( ( -LRB- cord-009571-mygj2nd4 2244 43 PA).During pa).dure VBG cord-009571-mygj2nd4 2244 44 the the DT cord-009571-mygj2nd4 2244 45 past past JJ cord-009571-mygj2nd4 2244 46 7 7 CD cord-009571-mygj2nd4 2244 47 years year NNS cord-009571-mygj2nd4 2244 48 , , , cord-009571-mygj2nd4 2244 49 15 15 CD cord-009571-mygj2nd4 2244 50 of of IN cord-009571-mygj2nd4 2244 51 140 140 CD cord-009571-mygj2nd4 2244 52 patients patient NNS cord-009571-mygj2nd4 2244 53 admitted admit VBN cord-009571-mygj2nd4 2244 54 to to IN cord-009571-mygj2nd4 2244 55 the the DT cord-009571-mygj2nd4 2244 56 Unit Unit NNP cord-009571-mygj2nd4 2244 57 with with IN cord-009571-mygj2nd4 2244 58 SLE SLE NNP cord-009571-mygj2nd4 2244 59 and and CC cord-009571-mygj2nd4 2244 60 4 4 CD cord-009571-mygj2nd4 2244 61 of of IN cord-009571-mygj2nd4 2244 62 8 8 CD cord-009571-mygj2nd4 2244 63 patients patient NNS cord-009571-mygj2nd4 2244 64 with with IN cord-009571-mygj2nd4 2244 65 PA PA NNP cord-009571-mygj2nd4 2244 66 developed develop VBD cord-009571-mygj2nd4 2244 67 an an DT cord-009571-mygj2nd4 2244 68 acute acute JJ cord-009571-mygj2nd4 2244 69 abdomen abdomen NN cord-009571-mygj2nd4 2244 70 . . . cord-009571-mygj2nd4 2245 1 In in IN cord-009571-mygj2nd4 2245 2 1 1 CD cord-009571-mygj2nd4 2245 3 I i NN cord-009571-mygj2nd4 2245 4 ( ( -LRB- cord-009571-mygj2nd4 2245 5 73 73 CD cord-009571-mygj2nd4 2245 6 % % NN cord-009571-mygj2nd4 2245 7 ) ) -RRB- cord-009571-mygj2nd4 2245 8 of of IN cord-009571-mygj2nd4 2245 9 those those DT cord-009571-mygj2nd4 2245 10 with with IN cord-009571-mygj2nd4 2245 11 SLE SLE NNP cord-009571-mygj2nd4 2245 12 and and CC cord-009571-mygj2nd4 2245 13 all all DT cord-009571-mygj2nd4 2245 14 4 4 CD cord-009571-mygj2nd4 2245 15 with with IN cord-009571-mygj2nd4 2245 16 PA PA NNP cord-009571-mygj2nd4 2245 17 , , , cord-009571-mygj2nd4 2245 18 the the DT cord-009571-mygj2nd4 2245 19 abdominal abdominal JJ cord-009571-mygj2nd4 2245 20 event event NN cord-009571-mygj2nd4 2245 21 was be VBD cord-009571-mygj2nd4 2245 22 secondary secondary JJ cord-009571-mygj2nd4 2245 23 to to IN cord-009571-mygj2nd4 2245 24 mesenteric mesenteric JJ cord-009571-mygj2nd4 2245 25 arteritis arteritis NN cord-009571-mygj2nd4 2245 26 . . . cord-009571-mygj2nd4 2246 1 The the DT cord-009571-mygj2nd4 2246 2 remaining remain VBG cord-009571-mygj2nd4 2246 3 4 4 CD cord-009571-mygj2nd4 2246 4 patients patient NNS cord-009571-mygj2nd4 2246 5 with with IN cord-009571-mygj2nd4 2246 6 SLE SLE NNP cord-009571-mygj2nd4 2246 7 had have VBD cord-009571-mygj2nd4 2246 8 polyserositis polyserositis NNP cord-009571-mygj2nd4 2246 9 ( ( -LRB- cord-009571-mygj2nd4 2246 10 2 2 CD cord-009571-mygj2nd4 2246 11 ) ) -RRB- cord-009571-mygj2nd4 2246 12 , , , cord-009571-mygj2nd4 2246 13 pancreatitis pancreatitis NN cord-009571-mygj2nd4 2246 14 ( ( -LRB- cord-009571-mygj2nd4 2246 15 I i NN cord-009571-mygj2nd4 2246 16 ) ) -RRB- cord-009571-mygj2nd4 2246 17 and and CC cord-009571-mygj2nd4 2246 18 , , , cord-009571-mygj2nd4 2246 19 in in IN cord-009571-mygj2nd4 2246 20 the the DT cord-009571-mygj2nd4 2246 21 other other JJ cord-009571-mygj2nd4 2246 22 patient patient NN cord-009571-mygj2nd4 2246 23 , , , cord-009571-mygj2nd4 2246 24 an an DT cord-009571-mygj2nd4 2246 25 undiagnosed undiagnosed JJ cord-009571-mygj2nd4 2246 26 recurrent recurrent JJ cord-009571-mygj2nd4 2246 27 syndrome syndrome NN cord-009571-mygj2nd4 2246 28 which which WDT cord-009571-mygj2nd4 2246 29 responded respond VBD cord-009571-mygj2nd4 2246 30 each each DT cord-009571-mygj2nd4 2246 31 time time NN cord-009571-mygj2nd4 2246 32 to to IN cord-009571-mygj2nd4 2246 33 increased increase VBN cord-009571-mygj2nd4 2246 34 corticosteroids corticosteroid NNS cord-009571-mygj2nd4 2246 35 alone alone RB cord-009571-mygj2nd4 2246 36 . . . cord-009571-mygj2nd4 2247 1 When when WRB cord-009571-mygj2nd4 2247 2 patients patient NNS cord-009571-mygj2nd4 2247 3 with with IN cord-009571-mygj2nd4 2247 4 SLE SLE NNP cord-009571-mygj2nd4 2247 5 and and CC cord-009571-mygj2nd4 2247 6 an an DT cord-009571-mygj2nd4 2247 7 acute acute JJ cord-009571-mygj2nd4 2247 8 abdomen abdomen NN cord-009571-mygj2nd4 2247 9 were be VBD cord-009571-mygj2nd4 2247 10 compared compare VBN cord-009571-mygj2nd4 2247 11 to to IN cord-009571-mygj2nd4 2247 12 the the DT cord-009571-mygj2nd4 2247 13 125 125 CD cord-009571-mygj2nd4 2247 14 patients patient NNS cord-009571-mygj2nd4 2247 15 without without IN cord-009571-mygj2nd4 2247 16 abdominal abdominal JJ cord-009571-mygj2nd4 2247 17 syn syn NN cord-009571-mygj2nd4 2247 18 - - HYPH cord-009571-mygj2nd4 2247 19 dromes drome NNS cord-009571-mygj2nd4 2247 20 , , , cord-009571-mygj2nd4 2247 21 the the DT cord-009571-mygj2nd4 2247 22 significant significant JJ cord-009571-mygj2nd4 2247 23 discriminating discriminating NN cord-009571-mygj2nd4 2247 24 features feature NNS cord-009571-mygj2nd4 2247 25 in in IN cord-009571-mygj2nd4 2247 26 the the DT cord-009571-mygj2nd4 2247 27 abdominal abdominal JJ cord-009571-mygj2nd4 2247 28 group group NN cord-009571-mygj2nd4 2247 29 were be VBD cord-009571-mygj2nd4 2247 30 increased increase VBN cord-009571-mygj2nd4 2247 31 peripheral peripheral JJ cord-009571-mygj2nd4 2247 32 vasculitis vasculitis NN cord-009571-mygj2nd4 2247 33 ( ( -LRB- cord-009571-mygj2nd4 2247 34 57 57 CD cord-009571-mygj2nd4 2247 35 % % NN cord-009571-mygj2nd4 2247 36 versus versus IN cord-009571-mygj2nd4 2247 37 25 25 CD cord-009571-mygj2nd4 2247 38 % % NN cord-009571-mygj2nd4 2247 39 , , , cord-009571-mygj2nd4 2247 40 P p NN cord-009571-mygj2nd4 2247 41 < < XX cord-009571-mygj2nd4 2247 42 0.025 0.025 CD cord-009571-mygj2nd4 2247 43 ) ) -RRB- cord-009571-mygj2nd4 2247 44 , , , cord-009571-mygj2nd4 2247 45 thrombocytopenia thrombocytopenia NN cord-009571-mygj2nd4 2247 46 ( ( -LRB- cord-009571-mygj2nd4 2247 47 57 57 CD cord-009571-mygj2nd4 2247 48 % % NN cord-009571-mygj2nd4 2247 49 versus versus IN cord-009571-mygj2nd4 2247 50 19 19 CD cord-009571-mygj2nd4 2247 51 % % NN cord-009571-mygj2nd4 2247 52 , , , cord-009571-mygj2nd4 2247 53 P p NN cord-009571-mygj2nd4 2247 54 < < XX cord-009571-mygj2nd4 2247 55 O.OOOS O.OOOS NNP cord-009571-mygj2nd4 2247 56 ) ) -RRB- cord-009571-mygj2nd4 2247 57 , , , cord-009571-mygj2nd4 2247 58 and and CC cord-009571-mygj2nd4 2247 59 presence presence NN cord-009571-mygj2nd4 2247 60 of of IN cord-009571-mygj2nd4 2247 61 rheumatoid rheumatoid NN cord-009571-mygj2nd4 2247 62 factor factor NN cord-009571-mygj2nd4 2247 63 by by IN cord-009571-mygj2nd4 2247 64 the the DT cord-009571-mygj2nd4 2247 65 Latex latex NN cord-009571-mygj2nd4 2247 66 test test NN cord-009571-mygj2nd4 2247 67 system system NN cord-009571-mygj2nd4 2247 68 ( ( -LRB- cord-009571-mygj2nd4 2247 69 92 92 CD cord-009571-mygj2nd4 2247 70 % % NN cord-009571-mygj2nd4 2247 71 versus versus IN cord-009571-mygj2nd4 2247 72 45 45 CD cord-009571-mygj2nd4 2247 73 % % NN cord-009571-mygj2nd4 2247 74 , , , cord-009571-mygj2nd4 2247 75 P p NN cord-009571-mygj2nd4 2247 76 < < XX cord-009571-mygj2nd4 2247 77 0.0005 0.0005 CD cord-009571-mygj2nd4 2247 78 ) ) -RRB- cord-009571-mygj2nd4 2247 79 . . . cord-009571-mygj2nd4 2248 1 Of of IN cord-009571-mygj2nd4 2248 2 the the DT cord-009571-mygj2nd4 2248 3 4 4 CD cord-009571-mygj2nd4 2248 4 patients patient NNS cord-009571-mygj2nd4 2248 5 with with IN cord-009571-mygj2nd4 2248 6 PA PA NNP cord-009571-mygj2nd4 2248 7 , , , cord-009571-mygj2nd4 2248 8 peripheral peripheral JJ cord-009571-mygj2nd4 2248 9 neuropathy neuropathy NN cord-009571-mygj2nd4 2248 10 was be VBD cord-009571-mygj2nd4 2248 11 present present JJ cord-009571-mygj2nd4 2248 12 in in IN cord-009571-mygj2nd4 2248 13 all all DT cord-009571-mygj2nd4 2248 14 , , , cord-009571-mygj2nd4 2248 15 thrombocytopenia thrombocytopenia NN cord-009571-mygj2nd4 2248 16 developed develop VBD cord-009571-mygj2nd4 2248 17 concomitant concomitant JJ cord-009571-mygj2nd4 2248 18 with with IN cord-009571-mygj2nd4 2248 19 the the DT cord-009571-mygj2nd4 2248 20 abdominal abdominal JJ cord-009571-mygj2nd4 2248 21 syndrome syndrome NN cord-009571-mygj2nd4 2248 22 in in IN cord-009571-mygj2nd4 2248 23 all all DT cord-009571-mygj2nd4 2248 24 , , , cord-009571-mygj2nd4 2248 25 and and CC cord-009571-mygj2nd4 2248 26 rheumatoid rheumatoid NN cord-009571-mygj2nd4 2248 27 factor factor NN cord-009571-mygj2nd4 2248 28 was be VBD cord-009571-mygj2nd4 2248 29 uniformly uniformly RB cord-009571-mygj2nd4 2248 30 present present JJ cord-009571-mygj2nd4 2248 31 in in IN cord-009571-mygj2nd4 2248 32 the the DT cord-009571-mygj2nd4 2248 33 3 3 CD cord-009571-mygj2nd4 2248 34 patients patient NNS cord-009571-mygj2nd4 2248 35 tested test VBN cord-009571-mygj2nd4 2248 36 ( ( -LRB- cord-009571-mygj2nd4 2248 37 1 1 CD cord-009571-mygj2nd4 2248 38 : : SYM cord-009571-mygj2nd4 2248 39 1280 1280 CD cord-009571-mygj2nd4 2248 40 , , , cord-009571-mygj2nd4 2248 41 1 1 CD cord-009571-mygj2nd4 2248 42 : : SYM cord-009571-mygj2nd4 2248 43 1280 1280 CD cord-009571-mygj2nd4 2248 44 , , , cord-009571-mygj2nd4 2248 45 I -PRON- PRP cord-009571-mygj2nd4 2248 46 : : : cord-009571-mygj2nd4 2248 47 10,240 10,240 CD cord-009571-mygj2nd4 2248 48 ) ) -RRB- cord-009571-mygj2nd4 2248 49 . . . cord-009571-mygj2nd4 2249 1 Eight eight CD cord-009571-mygj2nd4 2249 2 of of IN cord-009571-mygj2nd4 2249 3 those those DT cord-009571-mygj2nd4 2249 4 with with IN cord-009571-mygj2nd4 2249 5 SLE SLE NNP cord-009571-mygj2nd4 2249 6 and and CC cord-009571-mygj2nd4 2249 7 the the DT cord-009571-mygj2nd4 2249 8 4 4 CD cord-009571-mygj2nd4 2249 9 with with IN cord-009571-mygj2nd4 2249 10 PA PA NNP cord-009571-mygj2nd4 2249 11 died die VBD cord-009571-mygj2nd4 2249 12 from from IN cord-009571-mygj2nd4 2249 13 the the DT cord-009571-mygj2nd4 2249 14 abdominal abdominal JJ cord-009571-mygj2nd4 2249 15 catastrophe catastrophe NN cord-009571-mygj2nd4 2249 16 . . . cord-009571-mygj2nd4 2250 1 Six six CD cord-009571-mygj2nd4 2250 2 of of IN cord-009571-mygj2nd4 2250 3 the the DT cord-009571-mygj2nd4 2250 4 7 7 CD cord-009571-mygj2nd4 2250 5 surviving survive VBG cord-009571-mygj2nd4 2250 6 SLE SLE NNP cord-009571-mygj2nd4 2250 7 patients patient NNS cord-009571-mygj2nd4 2250 8 represent represent VBP cord-009571-mygj2nd4 2250 9 those those DT cord-009571-mygj2nd4 2250 10 most most RBS cord-009571-mygj2nd4 2250 11 recently recently RB cord-009571-mygj2nd4 2250 12 seen see VBN cord-009571-mygj2nd4 2250 13 . . . cord-009571-mygj2nd4 2251 1 Thus thus RB cord-009571-mygj2nd4 2251 2 , , , cord-009571-mygj2nd4 2251 3 in in IN cord-009571-mygj2nd4 2251 4 the the DT cord-009571-mygj2nd4 2251 5 patients patient NNS cord-009571-mygj2nd4 2251 6 with with IN cord-009571-mygj2nd4 2251 7 SLE SLE NNP cord-009571-mygj2nd4 2251 8 and and CC cord-009571-mygj2nd4 2251 9 PA PA NNP cord-009571-mygj2nd4 2251 10 , , , cord-009571-mygj2nd4 2251 11 the the DT cord-009571-mygj2nd4 2251 12 presence presence NN cord-009571-mygj2nd4 2251 13 of of IN cord-009571-mygj2nd4 2251 14 thrombocytopenia thrombocytopenia NN cord-009571-mygj2nd4 2251 15 and and CC cord-009571-mygj2nd4 2251 16 circulating circulate VBG cord-009571-mygj2nd4 2251 17 rheumatoid rheumatoid NN cord-009571-mygj2nd4 2251 18 factor factor NN cord-009571-mygj2nd4 2251 19 are be VBP cord-009571-mygj2nd4 2251 20 poor poor JJ cord-009571-mygj2nd4 2251 21 prognostic prognostic JJ cord-009571-mygj2nd4 2251 22 signs sign NNS cord-009571-mygj2nd4 2251 23 and and CC cord-009571-mygj2nd4 2251 24 may may MD cord-009571-mygj2nd4 2251 25 pathogenetically pathogenetically RB cord-009571-mygj2nd4 2251 26 predispose predispose VB cord-009571-mygj2nd4 2251 27 the the DT cord-009571-mygj2nd4 2251 28 patient patient NN cord-009571-mygj2nd4 2251 29 to to IN cord-009571-mygj2nd4 2251 30 intraabdominal intraabdominal JJ cord-009571-mygj2nd4 2251 31 arteritis arteritis NN cord-009571-mygj2nd4 2251 32 . . . cord-009571-mygj2nd4 2252 1 Outcome outcome NN cord-009571-mygj2nd4 2252 2 can can MD cord-009571-mygj2nd4 2252 3 only only RB cord-009571-mygj2nd4 2252 4 be be VB cord-009571-mygj2nd4 2252 5 favorably favorably RB cord-009571-mygj2nd4 2252 6 altered alter VBN cord-009571-mygj2nd4 2252 7 by by IN cord-009571-mygj2nd4 2252 8 early early JJ cord-009571-mygj2nd4 2252 9 recognition recognition NN cord-009571-mygj2nd4 2252 10 and and CC cord-009571-mygj2nd4 2252 11 prompt prompt JJ cord-009571-mygj2nd4 2252 12 institution institution NN cord-009571-mygj2nd4 2252 13 of of IN cord-009571-mygj2nd4 2252 14 appropriate appropriate JJ cord-009571-mygj2nd4 2252 15 medical medical JJ cord-009571-mygj2nd4 2252 16 and/or and/or CC cord-009571-mygj2nd4 2252 17 surgical surgical JJ cord-009571-mygj2nd4 2252 18 management management NN cord-009571-mygj2nd4 2252 19 . . .