id	sid	tid	token	lemma	pos
cord-006664-ykfvbypo	1	1	key	key	JJ
cord-006664-ykfvbypo	1	2	:	:	:
cord-006664-ykfvbypo	1	3	cord-006664-ykfvbypo	cord-006664-ykfvbypo	NNP
cord-006664-ykfvbypo	2	1	authors	author	NNS
cord-006664-ykfvbypo	2	2	:	:	:
cord-006664-ykfvbypo	2	3	McLaughlin	McLaughlin	NNP
cord-006664-ykfvbypo	2	4	,	,	,
cord-006664-ykfvbypo	2	5	R.	R.	NNP
cord-006664-ykfvbypo	2	6	;	;	:
cord-006664-ykfvbypo	2	7	Kelly	Kelly	NNP
cord-006664-ykfvbypo	2	8	,	,	,
cord-006664-ykfvbypo	2	9	C.	C.	NNP
cord-006664-ykfvbypo	2	10	J.	J.	NNP
cord-006664-ykfvbypo	2	11	;	;	:
cord-006664-ykfvbypo	2	12	Kay	Kay	NNP
cord-006664-ykfvbypo	2	13	,	,	,
cord-006664-ykfvbypo	2	14	E.	E.	NNP
cord-006664-ykfvbypo	2	15	;	;	:
cord-006664-ykfvbypo	2	16	Bouchier	Bouchier	NNP
cord-006664-ykfvbypo	2	17	-	-	HYPH
cord-006664-ykfvbypo	2	18	Hayes	Hayes	NNP
cord-006664-ykfvbypo	2	19	,	,	,
cord-006664-ykfvbypo	2	20	D.	D.	NNP
cord-006664-ykfvbypo	2	21	title	title	NN
cord-006664-ykfvbypo	2	22	:	:	:
cord-006664-ykfvbypo	2	23	The	the	DT
cord-006664-ykfvbypo	2	24	role	role	NN
cord-006664-ykfvbypo	2	25	of	of	IN
cord-006664-ykfvbypo	2	26	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	2	27	cell	cell	NN
cord-006664-ykfvbypo	2	28	death	death	NN
cord-006664-ykfvbypo	2	29	in	in	IN
cord-006664-ykfvbypo	2	30	cardiovascular	cardiovascular	JJ
cord-006664-ykfvbypo	2	31	disease	disease	NN
cord-006664-ykfvbypo	2	32	date	date	NN
cord-006664-ykfvbypo	2	33	:	:	:
cord-006664-ykfvbypo	2	34	2001	2001	CD
cord-006664-ykfvbypo	2	35	journal	journal	NN
cord-006664-ykfvbypo	2	36	:	:	:
cord-006664-ykfvbypo	2	37	Ir	Ir	NNP
cord-006664-ykfvbypo	2	38	J	J	NNP
cord-006664-ykfvbypo	2	39	Med	Med	NNP
cord-006664-ykfvbypo	2	40	Sci	Sci	NNP
cord-006664-ykfvbypo	2	41	DOI	DOI	NNP
cord-006664-ykfvbypo	2	42	:	:	:
cord-006664-ykfvbypo	2	43	10.1007	10.1007	CD
cord-006664-ykfvbypo	2	44	/	/	SYM
cord-006664-ykfvbypo	2	45	bf03168827	bf03168827	NN
cord-006664-ykfvbypo	2	46	sha	sha	NNP
cord-006664-ykfvbypo	2	47	:	:	:
cord-006664-ykfvbypo	3	1	6fd9251cbd88bf85ea977579a565aeec66a16be0	6fd9251cbd88bf85ea977579a565aeec66a16be0	CD
cord-006664-ykfvbypo	3	2	doc_id	doc_id	CD
cord-006664-ykfvbypo	4	1	:	:	:
cord-006664-ykfvbypo	4	2	6664	6664	CD
cord-006664-ykfvbypo	4	3	cord_uid	cord_uid	FW
cord-006664-ykfvbypo	4	4	:	:	:
cord-006664-ykfvbypo	5	1	ykfvbypo	ykfvbypo	NNP
cord-006664-ykfvbypo	5	2	BACKGROUND	BACKGROUND	NNP
cord-006664-ykfvbypo	5	3	:	:	:
cord-006664-ykfvbypo	5	4	Programmed	program	VBN
cord-006664-ykfvbypo	5	5	cell	cell	NN
cord-006664-ykfvbypo	5	6	death	death	NN
cord-006664-ykfvbypo	5	7	,	,	,
cord-006664-ykfvbypo	5	8	or	or	CC
cord-006664-ykfvbypo	5	9	apoptesis	apoptesis	NN
cord-006664-ykfvbypo	5	10	,	,	,
cord-006664-ykfvbypo	5	11	is	be	VBZ
cord-006664-ykfvbypo	5	12	a	a	DT
cord-006664-ykfvbypo	5	13	distinct	distinct	JJ
cord-006664-ykfvbypo	5	14	,	,	,
cord-006664-ykfvbypo	5	15	managed	manage	VBN
cord-006664-ykfvbypo	5	16	form	form	NN
cord-006664-ykfvbypo	5	17	of	of	IN
cord-006664-ykfvbypo	5	18	cell	cell	NN
cord-006664-ykfvbypo	5	19	death	death	NN
cord-006664-ykfvbypo	5	20	.	.	.
cord-006664-ykfvbypo	6	1	It	-PRON-	PRP
cord-006664-ykfvbypo	6	2	is	be	VBZ
cord-006664-ykfvbypo	6	3	fundamentally	fundamentally	RB
cord-006664-ykfvbypo	6	4	different	different	JJ
cord-006664-ykfvbypo	6	5	from	from	IN
cord-006664-ykfvbypo	6	6	necrosis	necrosis	NN
cord-006664-ykfvbypo	6	7	.	.	.
cord-006664-ykfvbypo	7	1	It	-PRON-	PRP
cord-006664-ykfvbypo	7	2	is	be	VBZ
cord-006664-ykfvbypo	7	3	a	a	DT
cord-006664-ykfvbypo	7	4	genetically	genetically	RB
cord-006664-ykfvbypo	7	5	controlled	control	VBN
cord-006664-ykfvbypo	7	6	,	,	,
cord-006664-ykfvbypo	7	7	energy	energy	NN
cord-006664-ykfvbypo	7	8	-	-	HYPH
cord-006664-ykfvbypo	7	9	dependent	dependent	JJ
cord-006664-ykfvbypo	7	10	method	method	NN
cord-006664-ykfvbypo	7	11	of	of	IN
cord-006664-ykfvbypo	7	12	cellular	cellular	JJ
cord-006664-ykfvbypo	7	13	deletion	deletion	NN
cord-006664-ykfvbypo	7	14	without	without	IN
cord-006664-ykfvbypo	7	15	inflammation	inflammation	NN
cord-006664-ykfvbypo	7	16	.	.	.
cord-006664-ykfvbypo	8	1	In	in	IN
cord-006664-ykfvbypo	8	2	the	the	DT
cord-006664-ykfvbypo	8	3	cardiovascular	cardiovascular	JJ
cord-006664-ykfvbypo	8	4	system	system	NN
cord-006664-ykfvbypo	8	5	,	,	,
cord-006664-ykfvbypo	8	6	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	8	7	occurs	occur	VBZ
cord-006664-ykfvbypo	8	8	as	as	IN
cord-006664-ykfvbypo	8	9	a	a	DT
cord-006664-ykfvbypo	8	10	primary	primary	JJ
cord-006664-ykfvbypo	8	11	and	and	CC
cord-006664-ykfvbypo	8	12	secondary	secondary	JJ
cord-006664-ykfvbypo	8	13	event	event	NN
cord-006664-ykfvbypo	8	14	in	in	IN
cord-006664-ykfvbypo	8	15	disease	disease	NN
cord-006664-ykfvbypo	8	16	pathogenesis	pathogenesis	NN
cord-006664-ykfvbypo	8	17	.	.	.
cord-006664-ykfvbypo	9	1	This	this	DT
cord-006664-ykfvbypo	9	2	review	review	NN
cord-006664-ykfvbypo	9	3	addresses	address	VBZ
cord-006664-ykfvbypo	9	4	our	-PRON-	PRP$
cord-006664-ykfvbypo	9	5	current	current	JJ
cord-006664-ykfvbypo	9	6	understanding	understanding	NN
cord-006664-ykfvbypo	9	7	of	of	IN
cord-006664-ykfvbypo	9	8	the	the	DT
cord-006664-ykfvbypo	9	9	initiation	initiation	NN
cord-006664-ykfvbypo	9	10	,	,	,
cord-006664-ykfvbypo	9	11	propagation	propagation	NN
cord-006664-ykfvbypo	9	12	and	and	CC
cord-006664-ykfvbypo	9	13	significance	significance	NN
cord-006664-ykfvbypo	9	14	of	of	IN
cord-006664-ykfvbypo	9	15	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	9	16	in	in	IN
cord-006664-ykfvbypo	9	17	the	the	DT
cord-006664-ykfvbypo	9	18	cardiovascular	cardiovascular	JJ
cord-006664-ykfvbypo	9	19	system	system	NN
cord-006664-ykfvbypo	9	20	,	,	,
cord-006664-ykfvbypo	9	21	as	as	RB
cord-006664-ykfvbypo	9	22	well	well	RB
cord-006664-ykfvbypo	9	23	as	as	IN
cord-006664-ykfvbypo	9	24	assessing	assess	VBG
cord-006664-ykfvbypo	9	25	therapeutic	therapeutic	JJ
cord-006664-ykfvbypo	9	26	potentials	potential	NNS
cord-006664-ykfvbypo	9	27	arising	arise	VBG
cord-006664-ykfvbypo	9	28	therefrom	therefrom	VBN
cord-006664-ykfvbypo	9	29	.	.	.
cord-006664-ykfvbypo	10	1	METHODS	methods	NN
cord-006664-ykfvbypo	10	2	:	:	:
cord-006664-ykfvbypo	11	1	A	a	DT
cord-006664-ykfvbypo	11	2	Medline	Medline	NNP
cord-006664-ykfvbypo	11	3	search	search	NN
cord-006664-ykfvbypo	11	4	was	be	VBD
cord-006664-ykfvbypo	11	5	performed	perform	VBN
cord-006664-ykfvbypo	11	6	and	and	CC
cord-006664-ykfvbypo	11	7	relevant	relevant	JJ
cord-006664-ykfvbypo	11	8	publications	publication	NNS
cord-006664-ykfvbypo	11	9	reviewed	review	VBN
cord-006664-ykfvbypo	11	10	.	.	.
cord-006664-ykfvbypo	12	1	Further	further	JJ
cord-006664-ykfvbypo	12	2	articles	article	NNS
cord-006664-ykfvbypo	12	3	were	be	VBD
cord-006664-ykfvbypo	12	4	obtained	obtain	VBN
cord-006664-ykfvbypo	12	5	from	from	IN
cord-006664-ykfvbypo	12	6	the	the	DT
cord-006664-ykfvbypo	12	7	references	reference	NNS
cord-006664-ykfvbypo	12	8	of	of	IN
cord-006664-ykfvbypo	12	9	these	these	DT
cord-006664-ykfvbypo	12	10	publications	publication	NNS
cord-006664-ykfvbypo	12	11	.	.	.
cord-006664-ykfvbypo	13	1	RESULTS	result	NNS
cord-006664-ykfvbypo	13	2	AND	and	CC
cord-006664-ykfvbypo	13	3	CONCLUSIONS	conclusion	NNS
cord-006664-ykfvbypo	13	4	:	:	:
cord-006664-ykfvbypo	14	1	Apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	14	2	cell	cell	NN
cord-006664-ykfvbypo	14	3	death	death	NN
cord-006664-ykfvbypo	14	4	is	be	VBZ
cord-006664-ykfvbypo	14	5	a	a	DT
cord-006664-ykfvbypo	14	6	key	key	JJ
cord-006664-ykfvbypo	14	7	element	element	NN
cord-006664-ykfvbypo	14	8	in	in	IN
cord-006664-ykfvbypo	14	9	the	the	DT
cord-006664-ykfvbypo	14	10	pathogenesis	pathogenesis	NN
cord-006664-ykfvbypo	14	11	and	and	CC
cord-006664-ykfvbypo	14	12	progression	progression	NN
cord-006664-ykfvbypo	14	13	of	of	IN
cord-006664-ykfvbypo	14	14	ischaemia	ischaemia	NN
cord-006664-ykfvbypo	14	15	-	-	HYPH
cord-006664-ykfvbypo	14	16	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	14	17	(	(	-LRB-
cord-006664-ykfvbypo	14	18	IR	IR	NNP
cord-006664-ykfvbypo	14	19	)	)	-RRB-
cord-006664-ykfvbypo	14	20	injury	injury	NN
cord-006664-ykfvbypo	14	21	,	,	,
cord-006664-ykfvbypo	14	22	cardiac	cardiac	JJ
cord-006664-ykfvbypo	14	23	failure	failure	NN
cord-006664-ykfvbypo	14	24	,	,	,
cord-006664-ykfvbypo	14	25	myocardial	myocardial	JJ
cord-006664-ykfvbypo	14	26	infarction	infarction	NN
cord-006664-ykfvbypo	14	27	,	,	,
cord-006664-ykfvbypo	14	28	atherosclerosis	atherosclerosis	NN
cord-006664-ykfvbypo	14	29	,	,	,
cord-006664-ykfvbypo	14	30	endothelial	endothelial	JJ
cord-006664-ykfvbypo	14	31	dysfunction	dysfunction	NN
cord-006664-ykfvbypo	14	32	and	and	CC
cord-006664-ykfvbypo	14	33	the	the	DT
cord-006664-ykfvbypo	14	34	clinical	clinical	JJ
cord-006664-ykfvbypo	14	35	syndromes	syndrome	NNS
cord-006664-ykfvbypo	14	36	which	which	WDT
cord-006664-ykfvbypo	14	37	these	these	DT
cord-006664-ykfvbypo	14	38	situations	situation	NNS
cord-006664-ykfvbypo	14	39	produce	produce	VBP
cord-006664-ykfvbypo	14	40	.	.	.
cord-006664-ykfvbypo	15	1	Our	-PRON-	PRP$
cord-006664-ykfvbypo	15	2	increased	increased	JJ
cord-006664-ykfvbypo	15	3	understanding	understanding	NN
cord-006664-ykfvbypo	15	4	of	of	IN
cord-006664-ykfvbypo	15	5	the	the	DT
cord-006664-ykfvbypo	15	6	role	role	NN
cord-006664-ykfvbypo	15	7	of	of	IN
cord-006664-ykfvbypo	15	8	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	15	9	in	in	IN
cord-006664-ykfvbypo	15	10	the	the	DT
cord-006664-ykfvbypo	15	11	pathogenesis	pathogenesis	NN
cord-006664-ykfvbypo	15	12	of	of	IN
cord-006664-ykfvbypo	15	13	cardiovascular	cardiovascular	JJ
cord-006664-ykfvbypo	15	14	disease	disease	NN
cord-006664-ykfvbypo	15	15	offers	offer	VBZ
cord-006664-ykfvbypo	15	16	potential	potential	NN
cord-006664-ykfvbypo	15	17	to	to	TO
cord-006664-ykfvbypo	15	18	develop	develop	VB
cord-006664-ykfvbypo	15	19	new	new	JJ
cord-006664-ykfvbypo	15	20	therapeutic	therapeutic	JJ
cord-006664-ykfvbypo	15	21	strategies	strategy	NNS
cord-006664-ykfvbypo	15	22	.	.	.
cord-006664-ykfvbypo	16	1	The	the	DT
cord-006664-ykfvbypo	16	2	term	term	NN
cord-006664-ykfvbypo	16	3	and	and	CC
cord-006664-ykfvbypo	16	4	concept	concept	NN
cord-006664-ykfvbypo	16	5	of	of	IN
cord-006664-ykfvbypo	16	6	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	16	7	or	or	CC
cord-006664-ykfvbypo	16	8	programmed	programmed	JJ
cord-006664-ykfvbypo	16	9	cell	cell	NN
cord-006664-ykfvbypo	16	10	death	death	NN
cord-006664-ykfvbypo	16	11	first	first	RB
cord-006664-ykfvbypo	16	12	appeared	appear	VBD
cord-006664-ykfvbypo	16	13	in	in	IN
cord-006664-ykfvbypo	16	14	the	the	DT
cord-006664-ykfvbypo	16	15	medical	medical	JJ
cord-006664-ykfvbypo	16	16	literature	literature	NN
cord-006664-ykfvbypo	16	17	in	in	IN
cord-006664-ykfvbypo	16	18	1972	1972	CD
cord-006664-ykfvbypo	16	19	.	.	.
cord-006664-ykfvbypo	16	20	'	'	''
cord-006664-ykfvbypo	17	1	Since	since	IN
cord-006664-ykfvbypo	17	2	then	then	RB
cord-006664-ykfvbypo	17	3	,	,	,
cord-006664-ykfvbypo	17	4	abnormalities	abnormality	NNS
cord-006664-ykfvbypo	17	5	of	of	IN
cord-006664-ykfvbypo	17	6	programmed	programmed	JJ
cord-006664-ykfvbypo	17	7	cell	cell	NN
cord-006664-ykfvbypo	17	8	death	death	NN
cord-006664-ykfvbypo	17	9	,	,	,
cord-006664-ykfvbypo	17	10	or	or	CC
cord-006664-ykfvbypo	17	11	manipulation	manipulation	NN
cord-006664-ykfvbypo	17	12	of	of	IN
cord-006664-ykfvbypo	17	13	the	the	DT
cord-006664-ykfvbypo	17	14	processes	process	NNS
cord-006664-ykfvbypo	17	15	of	of	IN
cord-006664-ykfvbypo	17	16	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	17	17	,	,	,
cord-006664-ykfvbypo	17	18	have	have	VBP
cord-006664-ykfvbypo	17	19	become	become	VBN
cord-006664-ykfvbypo	17	20	recognised	recognise	VBN
cord-006664-ykfvbypo	17	21	as	as	IN
cord-006664-ykfvbypo	17	22	being	be	VBG
cord-006664-ykfvbypo	17	23	of	of	IN
cord-006664-ykfvbypo	17	24	central	central	JJ
cord-006664-ykfvbypo	17	25	importance	importance	NN
cord-006664-ykfvbypo	17	26	in	in	IN
cord-006664-ykfvbypo	17	27	a	a	DT
cord-006664-ykfvbypo	17	28	multitude	multitude	NN
cord-006664-ykfvbypo	17	29	of	of	IN
cord-006664-ykfvbypo	17	30	pathological	pathological	JJ
cord-006664-ykfvbypo	17	31	states	state	NNS
cord-006664-ykfvbypo	17	32	.	.	.
cord-006664-ykfvbypo	18	1	The	the	DT
cord-006664-ykfvbypo	18	2	concept	concept	NN
cord-006664-ykfvbypo	18	3	that	that	WDT
cord-006664-ykfvbypo	18	4	cells	cell	NNS
cord-006664-ykfvbypo	18	5	possess	possess	VBP
cord-006664-ykfvbypo	18	6	a	a	DT
cord-006664-ykfvbypo	18	7	modifiable	modifiable	JJ
cord-006664-ykfvbypo	18	8	capacity	capacity	NN
cord-006664-ykfvbypo	18	9	to	to	TO
cord-006664-ykfvbypo	18	10	dictate	dictate	VB
cord-006664-ykfvbypo	18	11	whether	whether	IN
cord-006664-ykfvbypo	18	12	or	or	CC
cord-006664-ykfvbypo	18	13	not	not	RB
cord-006664-ykfvbypo	18	14	they	-PRON-	PRP
cord-006664-ykfvbypo	18	15	enter	enter	VBP
cord-006664-ykfvbypo	18	16	into	into	IN
cord-006664-ykfvbypo	18	17	a	a	DT
cord-006664-ykfvbypo	18	18	controlled	control	VBN
cord-006664-ykfvbypo	18	19	lethal	lethal	JJ
cord-006664-ykfvbypo	18	20	process	process	NN
cord-006664-ykfvbypo	18	21	is	be	VBZ
cord-006664-ykfvbypo	18	22	significant	significant	JJ
cord-006664-ykfvbypo	18	23	in	in	IN
cord-006664-ykfvbypo	18	24	understanding	understand	VBG
cord-006664-ykfvbypo	18	25	cellular	cellular	JJ
cord-006664-ykfvbypo	18	26	responses	response	NNS
cord-006664-ykfvbypo	18	27	to	to	IN
cord-006664-ykfvbypo	18	28	adverse	adverse	JJ
cord-006664-ykfvbypo	18	29	circumstances	circumstance	NNS
cord-006664-ykfvbypo	18	30	.	.	.
cord-006664-ykfvbypo	19	1	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	19	2	is	be	VBZ
cord-006664-ykfvbypo	19	3	a	a	DT
cord-006664-ykfvbypo	19	4	physiological	physiological	JJ
cord-006664-ykfvbypo	19	5	process	process	NN
cord-006664-ykfvbypo	19	6	for	for	IN
cord-006664-ykfvbypo	19	7	the	the	DT
cord-006664-ykfvbypo	19	8	deletion	deletion	NN
cord-006664-ykfvbypo	19	9	of	of	IN
cord-006664-ykfvbypo	19	10	unwanted	unwanted	JJ
cord-006664-ykfvbypo	19	11	or	or	CC
cord-006664-ykfvbypo	19	12	senescent	senescent	JJ
cord-006664-ykfvbypo	19	13	cells	cell	NNS
cord-006664-ykfvbypo	19	14	without	without	IN
cord-006664-ykfvbypo	19	15	inflammation	inflammation	NN
cord-006664-ykfvbypo	19	16	.	.	.
cord-006664-ykfvbypo	20	1	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	20	2	works	work	VBZ
cord-006664-ykfvbypo	20	3	synchronously	synchronously	RB
cord-006664-ykfvbypo	20	4	with	with	IN
cord-006664-ykfvbypo	20	5	,	,	,
cord-006664-ykfvbypo	20	6	but	but	CC
cord-006664-ykfvbypo	20	7	opposite	opposite	JJ
cord-006664-ykfvbypo	20	8	to	to	IN
cord-006664-ykfvbypo	20	9	,	,	,
cord-006664-ykfvbypo	20	10	mitosis	mitosis	NN
cord-006664-ykfvbypo	20	11	in	in	IN
cord-006664-ykfvbypo	20	12	counterbalancing	counterbalance	VBG
cord-006664-ykfvbypo	20	13	and	and	CC
cord-006664-ykfvbypo	20	14	regulating	regulate	VBG
cord-006664-ykfvbypo	20	15	tissue	tissue	NN
cord-006664-ykfvbypo	21	1	kinetics.=	kinetics.=	NNP
cord-006664-ykfvbypo	22	1	The	the	DT
cord-006664-ykfvbypo	22	2	regression	regression	NN
cord-006664-ykfvbypo	22	3	of	of	IN
cord-006664-ykfvbypo	22	4	interdigital	interdigital	NNP
cord-006664-ykfvbypo	22	5	webs	webs	NNP
cord-006664-ykfvbypo	22	6	is	be	VBZ
cord-006664-ykfvbypo	22	7	an	an	DT
cord-006664-ykfvbypo	22	8	example	example	NN
cord-006664-ykfvbypo	22	9	of	of	IN
cord-006664-ykfvbypo	22	10	physiological	physiological	JJ
cord-006664-ykfvbypo	22	11	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	22	12	cell	cell	NN
cord-006664-ykfvbypo	22	13	death	death	NN
cord-006664-ykfvbypo	22	14	.	.	.
cord-006664-ykfvbypo	23	1	6	6	CD
cord-006664-ykfvbypo	24	1	The	the	DT
cord-006664-ykfvbypo	24	2	process	process	NN
cord-006664-ykfvbypo	24	3	of	of	IN
cord-006664-ykfvbypo	24	4	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	24	5	is	be	VBZ
cord-006664-ykfvbypo	24	6	an	an	DT
cord-006664-ykfvbypo	24	7	energy	energy	NN
cord-006664-ykfvbypo	24	8	-	-	HYPH
cord-006664-ykfvbypo	24	9	dependent	dependent	JJ
cord-006664-ykfvbypo	24	10	,	,	,
cord-006664-ykfvbypo	24	11	tightly	tightly	RB
cord-006664-ykfvbypo	24	12	regulated	regulate	VBN
cord-006664-ykfvbypo	24	13	and	and	CC
cord-006664-ykfvbypo	24	14	genetically	genetically	RB
cord-006664-ykfvbypo	24	15	encoded	encode	VBN
cord-006664-ykfvbypo	24	16	mechanism	mechanism	NN
cord-006664-ykfvbypo	24	17	of	of	IN
cord-006664-ykfvbypo	24	18	individual	individual	JJ
cord-006664-ykfvbypo	24	19	cell	cell	NN
cord-006664-ykfvbypo	24	20	disposal	disposal	NN
cord-006664-ykfvbypo	24	21	.	.	.
cord-006664-ykfvbypo	25	1	The	the	DT
cord-006664-ykfvbypo	25	2	ubiquitous	ubiquitous	JJ
cord-006664-ykfvbypo	25	3	process	process	NN
cord-006664-ykfvbypo	25	4	of	of	IN
cord-006664-ykfvbypo	25	5	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	25	6	is	be	VBZ
cord-006664-ykfvbypo	25	7	seen	see	VBN
cord-006664-ykfvbypo	25	8	in	in	IN
cord-006664-ykfvbypo	25	9	its	-PRON-	PRP$
cord-006664-ykfvbypo	25	10	physiological	physiological	JJ
cord-006664-ykfvbypo	25	11	context	context	NN
cord-006664-ykfvbypo	25	12	,	,	,
cord-006664-ykfvbypo	25	13	actively	actively	RB
cord-006664-ykfvbypo	25	14	deleting	delete	VBG
cord-006664-ykfvbypo	25	15	cells	cell	NNS
cord-006664-ykfvbypo	25	16	during	during	IN
cord-006664-ykfvbypo	25	17	embryogenesis	embryogenesis	NN
cord-006664-ykfvbypo	25	18	,	,	,
cord-006664-ykfvbypo	25	19	metamorphosis	metamorphosis	NN
cord-006664-ykfvbypo	25	20	,	,	,
cord-006664-ykfvbypo	25	21	tissue	tissue	NN
cord-006664-ykfvbypo	25	22	atrophy	atrophy	NN
cord-006664-ykfvbypo	25	23	,	,	,
cord-006664-ykfvbypo	25	24	T	t	NN
cord-006664-ykfvbypo	25	25	-	-	HYPH
cord-006664-ykfvbypo	25	26	cell	cell	NN
cord-006664-ykfvbypo	25	27	killing	killing	NN
cord-006664-ykfvbypo	25	28	tumour	tumour	NN
cord-006664-ykfvbypo	25	29	regression	regression	NN
cord-006664-ykfvbypo	25	30	and	and	CC
cord-006664-ykfvbypo	25	31	turnover	turnover	NN
cord-006664-ykfvbypo	25	32	of	of	IN
cord-006664-ykfvbypo	25	33	intestinal	intestinal	JJ
cord-006664-ykfvbypo	25	34	epithelial	epithelial	JJ
cord-006664-ykfvbypo	25	35	cells	cell	NNS
cord-006664-ykfvbypo	25	36	.	.	.
cord-006664-ykfvbypo	26	1	'	'	``
cord-006664-ykfvbypo	26	2	•	•	$
cord-006664-ykfvbypo	26	3	5	5	CD
cord-006664-ykfvbypo	27	1	'	'	``
cord-006664-ykfvbypo	27	2	7	7	CD
cord-006664-ykfvbypo	27	3	'	'	CD
cord-006664-ykfvbypo	27	4	8	8	CD
cord-006664-ykfvbypo	27	5	Cellular	cellular	JJ
cord-006664-ykfvbypo	27	6	resistance	resistance	NN
cord-006664-ykfvbypo	27	7	to	to	IN
cord-006664-ykfvbypo	27	8	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	27	9	is	be	VBZ
cord-006664-ykfvbypo	27	10	exhibited	exhibit	VBN
cord-006664-ykfvbypo	27	11	in	in	IN
cord-006664-ykfvbypo	27	12	abnormalities	abnormality	NNS
cord-006664-ykfvbypo	27	13	of	of	IN
cord-006664-ykfvbypo	27	14	these	these	DT
cord-006664-ykfvbypo	27	15	processes	process	NNS
cord-006664-ykfvbypo	27	16	and	and	CC
cord-006664-ykfvbypo	27	17	particularly	particularly	RB
cord-006664-ykfvbypo	27	18	in	in	IN
cord-006664-ykfvbypo	27	19	carcinogenesis	carcinogenesis	NN
cord-006664-ykfvbypo	27	20	.	.	.
cord-006664-ykfvbypo	28	1	9	9	CD
cord-006664-ykfvbypo	29	1	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	29	2	is	be	VBZ
cord-006664-ykfvbypo	29	3	exhibited	exhibit	VBN
cord-006664-ykfvbypo	29	4	pathologically	pathologically	RB
cord-006664-ykfvbypo	29	5	in	in	IN
cord-006664-ykfvbypo	29	6	response	response	NN
cord-006664-ykfvbypo	29	7	to	to	IN
cord-006664-ykfvbypo	29	8	stresses	stress	NNS
cord-006664-ykfvbypo	29	9	such	such	JJ
cord-006664-ykfvbypo	29	10	as	as	IN
cord-006664-ykfvbypo	29	11	ischaemia	ischaemia	NN
cord-006664-ykfvbypo	29	12	-	-	HYPH
cord-006664-ykfvbypo	29	13	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	29	14	(	(	-LRB-
cord-006664-ykfvbypo	29	15	IR	IR	NNP
cord-006664-ykfvbypo	29	16	)	)	-RRB-
cord-006664-ykfvbypo	29	17	hyperthermia	hyperthermia	NN
cord-006664-ykfvbypo	29	18	,	,	,
cord-006664-ykfvbypo	29	19	radiotherapy	radiotherapy	NN
cord-006664-ykfvbypo	29	20	and	and	CC
cord-006664-ykfvbypo	29	21	pharmacological	pharmacological	JJ
cord-006664-ykfvbypo	29	22	agents	agent	NNS
cord-006664-ykfvbypo	29	23	.	.	.
cord-006664-ykfvbypo	30	1	10	10	CD
cord-006664-ykfvbypo	30	2	.1	.1	NNS
cord-006664-ykfvbypo	30	3	.	.	.
cord-006664-ykfvbypo	31	1	However	however	RB
cord-006664-ykfvbypo	31	2	,	,	,
cord-006664-ykfvbypo	31	3	pathological	pathological	JJ
cord-006664-ykfvbypo	31	4	or	or	CC
cord-006664-ykfvbypo	31	5	inappropriate	inappropriate	JJ
cord-006664-ykfvbypo	31	6	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	31	7	has	have	VBZ
cord-006664-ykfvbypo	31	8	significant	significant	JJ
cord-006664-ykfvbypo	31	9	structural	structural	JJ
cord-006664-ykfvbypo	31	10	and	and	CC
cord-006664-ykfvbypo	31	11	functional	functional	JJ
cord-006664-ykfvbypo	31	12	implications	implication	NNS
cord-006664-ykfvbypo	31	13	for	for	IN
cord-006664-ykfvbypo	31	14	the	the	DT
cord-006664-ykfvbypo	31	15	involved	involved	JJ
cord-006664-ykfvbypo	31	16	end	end	NN
cord-006664-ykfvbypo	31	17	organs	organ	NNS
cord-006664-ykfvbypo	31	18	.	.	.
cord-006664-ykfvbypo	32	1	In	in	IN
cord-006664-ykfvbypo	32	2	mature	mature	JJ
cord-006664-ykfvbypo	32	3	organisms	organism	NNS
cord-006664-ykfvbypo	32	4	,	,	,
cord-006664-ykfvbypo	32	5	ongoing	ongoing	JJ
cord-006664-ykfvbypo	32	6	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	32	7	maintains	maintain	VBZ
cord-006664-ykfvbypo	32	8	cellular	cellular	JJ
cord-006664-ykfvbypo	32	9	homeostasis	homeostasis	NN
cord-006664-ykfvbypo	32	10	in	in	IN
cord-006664-ykfvbypo	32	11	renewing	renew	VBG
cord-006664-ykfvbypo	32	12	cell	cell	NN
cord-006664-ykfvbypo	32	13	types	type	NNS
cord-006664-ykfvbypo	32	14	such	such	JJ
cord-006664-ykfvbypo	32	15	as	as	IN
cord-006664-ykfvbypo	32	16	intestinal	intestinal	JJ
cord-006664-ykfvbypo	32	17	epithelium	epithelium	NN
cord-006664-ykfvbypo	32	18	and	and	CC
cord-006664-ykfvbypo	32	19	leucocytes	leucocyte	NNS
cord-006664-ykfvbypo	32	20	.	.	.
cord-006664-ykfvbypo	33	1	In	in	IN
cord-006664-ykfvbypo	33	2	contrast	contrast	NN
cord-006664-ykfvbypo	33	3	,	,	,
cord-006664-ykfvbypo	33	4	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	33	5	is	be	VBZ
cord-006664-ykfvbypo	33	6	not	not	RB
cord-006664-ykfvbypo	33	7	a	a	DT
cord-006664-ykfvbypo	33	8	feature	feature	NN
cord-006664-ykfvbypo	33	9	of	of	IN
cord-006664-ykfvbypo	33	10	non	non	JJ
cord-006664-ykfvbypo	33	11	-	-	JJ
cord-006664-ykfvbypo	33	12	renewable	renewable	JJ
cord-006664-ykfvbypo	33	13	parenchymal	parenchymal	NN
cord-006664-ykfvbypo	33	14	cells	cell	NNS
cord-006664-ykfvbypo	33	15	in	in	IN
cord-006664-ykfvbypo	33	16	the	the	DT
cord-006664-ykfvbypo	33	17	normal	normal	JJ
cord-006664-ykfvbypo	33	18	course	course	NN
cord-006664-ykfvbypo	33	19	of	of	IN
cord-006664-ykfvbypo	33	20	events	event	NNS
cord-006664-ykfvbypo	33	21	.	.	.
cord-006664-ykfvbypo	34	1	This	this	DT
cord-006664-ykfvbypo	34	2	is	be	VBZ
cord-006664-ykfvbypo	34	3	particularly	particularly	RB
cord-006664-ykfvbypo	34	4	so	so	RB
cord-006664-ykfvbypo	34	5	in	in	IN
cord-006664-ykfvbypo	34	6	terminally	terminally	RB
cord-006664-ykfvbypo	34	7	differentiated	differentiate	VBN
cord-006664-ykfvbypo	34	8	cells	cell	NNS
cord-006664-ykfvbypo	34	9	such	such	JJ
cord-006664-ykfvbypo	34	10	as	as	IN
cord-006664-ykfvbypo	34	11	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	34	12	.	.	.
cord-006664-ykfvbypo	35	1	In	in	IN
cord-006664-ykfvbypo	35	2	the	the	DT
cord-006664-ykfvbypo	35	3	myocardium	myocardium	NN
cord-006664-ykfvbypo	35	4	,	,	,
cord-006664-ykfvbypo	35	5	the	the	DT
cord-006664-ykfvbypo	35	6	finding	finding	NN
cord-006664-ykfvbypo	35	7	of	of	IN
cord-006664-ykfvbypo	35	8	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	35	9	after	after	IN
cord-006664-ykfvbypo	35	10	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	35	11	is	be	VBZ
cord-006664-ykfvbypo	35	12	particularly	particularly	RB
cord-006664-ykfvbypo	35	13	significant	significant	JJ
cord-006664-ykfvbypo	35	14	as	as	IN
cord-006664-ykfvbypo	35	15	it	-PRON-	PRP
cord-006664-ykfvbypo	35	16	implies	imply	VBZ
cord-006664-ykfvbypo	35	17	late	late	JJ
cord-006664-ykfvbypo	35	18	and	and	CC
cord-006664-ykfvbypo	35	19	potentially	potentially	RB
cord-006664-ykfvbypo	35	20	avoidable	avoidable	JJ
cord-006664-ykfvbypo	35	21	cell	cell	NN
cord-006664-ykfvbypo	35	22	death	death	NN
cord-006664-ykfvbypo	35	23	.	.	.
cord-006664-ykfvbypo	36	1	1	1	CD
cord-006664-ykfvbypo	36	2	16	16	CD
cord-006664-ykfvbypo	37	1	In	in	IN
cord-006664-ykfvbypo	37	2	cardiovascular	cardiovascular	JJ
cord-006664-ykfvbypo	37	3	disease	disease	NN
cord-006664-ykfvbypo	37	4	,	,	,
cord-006664-ykfvbypo	37	5	developments	development	NNS
cord-006664-ykfvbypo	37	6	in	in	IN
cord-006664-ykfvbypo	37	7	molecular	molecular	JJ
cord-006664-ykfvbypo	37	8	biology	biology	NN
cord-006664-ykfvbypo	37	9	have	have	VBP
cord-006664-ykfvbypo	37	10	facilitated	facilitate	VBN
cord-006664-ykfvbypo	37	11	an	an	DT
cord-006664-ykfvbypo	37	12	increasing	increase	VBG
cord-006664-ykfvbypo	37	13	appreciation	appreciation	NN
cord-006664-ykfvbypo	37	14	of	of	IN
cord-006664-ykfvbypo	37	15	the	the	DT
cord-006664-ykfvbypo	37	16	role	role	NN
cord-006664-ykfvbypo	37	17	of	of	IN
cord-006664-ykfvbypo	37	18	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	37	19	,	,	,
cord-006664-ykfvbypo	37	20	not	not	RB
cord-006664-ykfvbypo	37	21	only	only	RB
cord-006664-ykfvbypo	37	22	in	in	IN
cord-006664-ykfvbypo	37	23	heart	heart	NN
cord-006664-ykfvbypo	37	24	failure	failure	NN
cord-006664-ykfvbypo	37	25	and	and	CC
cord-006664-ykfvbypo	37	26	myocardial	myocardial	JJ
cord-006664-ykfvbypo	37	27	infarction	infarction	NN
cord-006664-ykfvbypo	37	28	but	but	CC
cord-006664-ykfvbypo	37	29	also	also	RB
cord-006664-ykfvbypo	37	30	in	in	IN
cord-006664-ykfvbypo	37	31	IR	IR	NNP
cord-006664-ykfvbypo	37	32	injury	injury	NN
cord-006664-ykfvbypo	37	33	,	,	,
cord-006664-ykfvbypo	37	34	ageing	age	VBG
cord-006664-ykfvbypo	37	35	,	,	,
cord-006664-ykfvbypo	37	36	vascular	vascular	JJ
cord-006664-ykfvbypo	37	37	wall	wall	NN
cord-006664-ykfvbypo	37	38	remodelling	remodelling	NN
cord-006664-ykfvbypo	37	39	and	and	CC
cord-006664-ykfvbypo	37	40	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	37	41	plaque	plaque	NN
cord-006664-ykfvbypo	37	42	destabilisation	destabilisation	NN
cord-006664-ykfvbypo	37	43	.	.	.
cord-006664-ykfvbypo	37	44	'	'	''
cord-006664-ykfvbypo	37	45	'	'	''
cord-006664-ykfvbypo	38	1	-21	-21	NNP
cord-006664-ykfvbypo	39	1	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	39	2	is	be	VBZ
cord-006664-ykfvbypo	39	3	now	now	RB
cord-006664-ykfvbypo	39	4	recognised	recognise	VBN
cord-006664-ykfvbypo	39	5	to	to	IN
cord-006664-ykfvbypo	39	6	not	not	RB
cord-006664-ykfvbypo	39	7	only	only	RB
cord-006664-ykfvbypo	39	8	contribute	contribute	VB
cord-006664-ykfvbypo	39	9	to	to	IN
cord-006664-ykfvbypo	39	10	the	the	DT
cord-006664-ykfvbypo	39	11	initiation	initiation	NN
cord-006664-ykfvbypo	39	12	of	of	IN
cord-006664-ykfvbypo	39	13	these	these	DT
cord-006664-ykfvbypo	39	14	disease	disease	NN
cord-006664-ykfvbypo	39	15	states	state	NNS
cord-006664-ykfvbypo	39	16	but	but	CC
cord-006664-ykfvbypo	39	17	also	also	RB
cord-006664-ykfvbypo	39	18	to	to	TO
cord-006664-ykfvbypo	39	19	influence	influence	VB
cord-006664-ykfvbypo	39	20	long	long	JJ
cord-006664-ykfvbypo	39	21	-	-	HYPH
cord-006664-ykfvbypo	39	22	term	term	NN
cord-006664-ykfvbypo	39	23	outcome	outcome	NN
cord-006664-ykfvbypo	39	24	in	in	IN
cord-006664-ykfvbypo	39	25	terms	term	NNS
cord-006664-ykfvbypo	39	26	of	of	IN
cord-006664-ykfvbypo	39	27	eventual	eventual	JJ
cord-006664-ykfvbypo	39	28	myocardial	myocardial	JJ
cord-006664-ykfvbypo	39	29	pump	pump	NN
cord-006664-ykfvbypo	39	30	failure	failure	NN
cord-006664-ykfvbypo	39	31	or	or	CC
cord-006664-ykfvbypo	39	32	arterial	arterial	JJ
cord-006664-ykfvbypo	39	33	occlusion	occlusion	NN
cord-006664-ykfvbypo	39	34	.	.	.
cord-006664-ykfvbypo	40	1	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	40	2	occurs	occur	VBZ
cord-006664-ykfvbypo	40	3	acutely	acutely	RB
cord-006664-ykfvbypo	40	4	but	but	CC
cord-006664-ykfvbypo	40	5	also	also	RB
cord-006664-ykfvbypo	40	6	persists	persist	VBZ
cord-006664-ykfvbypo	40	7	after	after	IN
cord-006664-ykfvbypo	40	8	an	an	DT
cord-006664-ykfvbypo	40	9	initial	initial	JJ
cord-006664-ykfvbypo	40	10	inflammatory	inflammatory	JJ
cord-006664-ykfvbypo	40	11	or	or	CC
cord-006664-ykfvbypo	40	12	ischaemic	ischaemic	JJ
cord-006664-ykfvbypo	40	13	insult	insult	NN
cord-006664-ykfvbypo	40	14	,	,	,
cord-006664-ykfvbypo	40	15	thus	thus	RB
cord-006664-ykfvbypo	40	16	perpetuating	perpetuate	VBG
cord-006664-ykfvbypo	40	17	the	the	DT
cord-006664-ykfvbypo	40	18	injury	injury	NN
cord-006664-ykfvbypo	40	19	sustained	sustain	VBN
cord-006664-ykfvbypo	40	20	.	.	.
cord-006664-ykfvbypo	41	1	As	as	IN
cord-006664-ykfvbypo	41	2	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	41	3	is	be	VBZ
cord-006664-ykfvbypo	41	4	a	a	DT
cord-006664-ykfvbypo	41	5	process	process	NN
cord-006664-ykfvbypo	41	6	that	that	WDT
cord-006664-ykfvbypo	41	7	can	can	MD
cord-006664-ykfvbypo	41	8	be	be	VB
cord-006664-ykfvbypo	41	9	potentially	potentially	RB
cord-006664-ykfvbypo	41	10	attenuated	attenuate	VBN
cord-006664-ykfvbypo	41	11	,	,	,
cord-006664-ykfvbypo	41	12	recognition	recognition	NN
cord-006664-ykfvbypo	41	13	of	of	IN
cord-006664-ykfvbypo	41	14	its	-PRON-	PRP$
cord-006664-ykfvbypo	41	15	contribution	contribution	NN
cord-006664-ykfvbypo	41	16	to	to	IN
cord-006664-ykfvbypo	41	17	cardiovascular	cardiovascular	JJ
cord-006664-ykfvbypo	41	18	disease	disease	NN
cord-006664-ykfvbypo	41	19	opens	open	VBZ
cord-006664-ykfvbypo	41	20	exciting	exciting	JJ
cord-006664-ykfvbypo	41	21	new	new	JJ
cord-006664-ykfvbypo	41	22	therapeutic	therapeutic	JJ
cord-006664-ykfvbypo	41	23	avenues	avenue	NNS
cord-006664-ykfvbypo	41	24	.	.	.
cord-006664-ykfvbypo	42	1	Apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	42	2	cell	cell	NN
cord-006664-ykfvbypo	42	3	death	death	NN
cord-006664-ykfvbypo	42	4	is	be	VBZ
cord-006664-ykfvbypo	42	5	a	a	DT
cord-006664-ykfvbypo	42	6	morphologically	morphologically	RB
cord-006664-ykfvbypo	42	7	characteristic	characteristic	JJ
cord-006664-ykfvbypo	42	8	process	process	NN
cord-006664-ykfvbypo	42	9	identified	identify	VBN
cord-006664-ykfvbypo	42	10	by	by	IN
cord-006664-ykfvbypo	42	11	a	a	DT
cord-006664-ykfvbypo	42	12	series	series	NN
cord-006664-ykfvbypo	42	13	of	of	IN
cord-006664-ykfvbypo	42	14	discrete	discrete	JJ
cord-006664-ykfvbypo	42	15	distinguishable	distinguishable	JJ
cord-006664-ykfvbypo	42	16	steps	step	NNS
cord-006664-ykfvbypo	42	17	.	.	.
cord-006664-ykfvbypo	43	1	Initially	initially	RB
cord-006664-ykfvbypo	43	2	,	,	,
cord-006664-ykfvbypo	43	3	detachment	detachment	NN
cord-006664-ykfvbypo	43	4	of	of	IN
cord-006664-ykfvbypo	43	5	the	the	DT
cord-006664-ykfvbypo	43	6	affected	affected	JJ
cord-006664-ykfvbypo	43	7	cell	cell	NN
cord-006664-ykfvbypo	43	8	from	from	IN
cord-006664-ykfvbypo	43	9	its	-PRON-	PRP$
cord-006664-ykfvbypo	43	10	surrounding	surround	VBG
cord-006664-ykfvbypo	43	11	cells	cell	NNS
cord-006664-ykfvbypo	43	12	occurs	occur	VBZ
cord-006664-ykfvbypo	43	13	.	.	.
cord-006664-ykfvbypo	44	1	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	44	2	proceeds	proceed	VBZ
cord-006664-ykfvbypo	44	3	in	in	IN
cord-006664-ykfvbypo	44	4	an	an	DT
cord-006664-ykfvbypo	44	5	orderly	orderly	JJ
cord-006664-ykfvbypo	44	6	controlled	control	VBN
cord-006664-ykfvbypo	44	7	fashion	fashion	NN
cord-006664-ykfvbypo	44	8	with	with	IN
cord-006664-ykfvbypo	44	9	characteristic	characteristic	JJ
cord-006664-ykfvbypo	44	10	cell	cell	NN
cord-006664-ykfvbypo	44	11	volume	volume	NN
cord-006664-ykfvbypo	44	12	reduction	reduction	NN
cord-006664-ykfvbypo	44	13	followed	follow	VBN
cord-006664-ykfvbypo	44	14	by	by	IN
cord-006664-ykfvbypo	44	15	convolution	convolution	NN
cord-006664-ykfvbypo	44	16	and	and	CC
cord-006664-ykfvbypo	44	17	blebbing	blebbing	NN
cord-006664-ykfvbypo	44	18	of	of	IN
cord-006664-ykfvbypo	44	19	the	the	DT
cord-006664-ykfvbypo	44	20	cell	cell	NN
cord-006664-ykfvbypo	44	21	membrane	membrane	NN
cord-006664-ykfvbypo	44	22	.	.	.
cord-006664-ykfvbypo	45	1	Condensation	condensation	NN
cord-006664-ykfvbypo	45	2	of	of	IN
cord-006664-ykfvbypo	45	3	the	the	DT
cord-006664-ykfvbypo	45	4	cytoplasm	cytoplasm	NN
cord-006664-ykfvbypo	45	5	is	be	VBZ
cord-006664-ykfvbypo	45	6	reflected	reflect	VBN
cord-006664-ykfvbypo	45	7	in	in	IN
cord-006664-ykfvbypo	45	8	an	an	DT
cord-006664-ykfvbypo	45	9	increased	increase	VBN
cord-006664-ykfvbypo	45	10	cell	cell	NN
cord-006664-ykfvbypo	45	11	density	density	NN
cord-006664-ykfvbypo	45	12	.	.	.
cord-006664-ykfvbypo	46	1	The	the	DT
cord-006664-ykfvbypo	46	2	nuclear	nuclear	JJ
cord-006664-ykfvbypo	46	3	chromatin	chromatin	NN
cord-006664-ykfvbypo	46	4	condenses	condense	VBZ
cord-006664-ykfvbypo	46	5	,	,	,
cord-006664-ykfvbypo	46	6	in	in	IN
cord-006664-ykfvbypo	46	7	association	association	NN
cord-006664-ykfvbypo	46	8	with	with	IN
cord-006664-ykfvbypo	46	9	activation	activation	NN
cord-006664-ykfvbypo	46	10	of	of	IN
cord-006664-ykfvbypo	46	11	an	an	DT
cord-006664-ykfvbypo	46	12	endogenous	endogenous	JJ
cord-006664-ykfvbypo	46	13	endonuclease	endonuclease	NN
cord-006664-ykfvbypo	46	14	,	,	,
cord-006664-ykfvbypo	46	15	and	and	CC
cord-006664-ykfvbypo	46	16	gathers	gather	VBZ
cord-006664-ykfvbypo	46	17	beneath	beneath	IN
cord-006664-ykfvbypo	46	18	the	the	DT
cord-006664-ykfvbypo	46	19	nuclear	nuclear	JJ
cord-006664-ykfvbypo	46	20	membrane	membrane	NN
cord-006664-ykfvbypo	46	21	.	.	.
cord-006664-ykfvbypo	47	1	The	the	DT
cord-006664-ykfvbypo	47	2	entire	entire	JJ
cord-006664-ykfvbypo	47	3	cell	cell	NN
cord-006664-ykfvbypo	47	4	may	may	MD
cord-006664-ykfvbypo	47	5	now	now	RB
cord-006664-ykfvbypo	47	6	split	split	VB
cord-006664-ykfvbypo	47	7	into	into	IN
cord-006664-ykfvbypo	47	8	membranebound	membranebound	JJ
cord-006664-ykfvbypo	47	9	structures	structure	NNS
cord-006664-ykfvbypo	47	10	with	with	IN
cord-006664-ykfvbypo	47	11	preserved	preserve	VBN
cord-006664-ykfvbypo	47	12	organelle	organelle	NN
cord-006664-ykfvbypo	47	13	structures	structure	NNS
cord-006664-ykfvbypo	47	14	.	.	.
cord-006664-ykfvbypo	48	1	These	these	DT
cord-006664-ykfvbypo	48	2	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	48	3	bodies	body	NNS
cord-006664-ykfvbypo	48	4	may	may	MD
cord-006664-ykfvbypo	48	5	be	be	VB
cord-006664-ykfvbypo	48	6	visualised	visualise	VBN
cord-006664-ykfvbypo	48	7	within	within	IN
cord-006664-ykfvbypo	48	8	tissues	tissue	NNS
cord-006664-ykfvbypo	48	9	at	at	IN
cord-006664-ykfvbypo	48	10	this	this	DT
cord-006664-ykfvbypo	48	11	stage	stage	NN
cord-006664-ykfvbypo	48	12	.	.	.
cord-006664-ykfvbypo	49	1	The	the	DT
cord-006664-ykfvbypo	49	2	cell	cell	NN
cord-006664-ykfvbypo	49	3	now	now	RB
cord-006664-ykfvbypo	49	4	becomes	become	VBZ
cord-006664-ykfvbypo	49	5	subject	subject	JJ
cord-006664-ykfvbypo	49	6	to	to	IN
cord-006664-ykfvbypo	49	7	tissue	tissue	NN
cord-006664-ykfvbypo	49	8	phagocytic	phagocytic	JJ
cord-006664-ykfvbypo	49	9	cell	cell	NN
cord-006664-ykfvbypo	49	10	recognition	recognition	NN
cord-006664-ykfvbypo	49	11	and	and	CC
cord-006664-ykfvbypo	49	12	action	action	NN
cord-006664-ykfvbypo	49	13	.	.	.
cord-006664-ykfvbypo	50	1	Membrane	membrane	NN
cord-006664-ykfvbypo	50	2	integrity	integrity	NN
cord-006664-ykfvbypo	50	3	is	be	VBZ
cord-006664-ykfvbypo	50	4	maintained	maintain	VBN
cord-006664-ykfvbypo	50	5	throughout	throughout	IN
cord-006664-ykfvbypo	50	6	the	the	DT
cord-006664-ykfvbypo	50	7	process	process	NN
cord-006664-ykfvbypo	50	8	,	,	,
cord-006664-ykfvbypo	50	9	in	in	IN
cord-006664-ykfvbypo	50	10	contrast	contrast	NN
cord-006664-ykfvbypo	50	11	to	to	IN
cord-006664-ykfvbypo	50	12	the	the	DT
cord-006664-ykfvbypo	50	13	swelling	swell	VBG
cord-006664-ykfvbypo	50	14	and	and	CC
cord-006664-ykfvbypo	50	15	subsequent	subsequent	JJ
cord-006664-ykfvbypo	50	16	rupture	rupture	NN
cord-006664-ykfvbypo	50	17	of	of	IN
cord-006664-ykfvbypo	50	18	a	a	DT
cord-006664-ykfvbypo	50	19	cell	cell	NN
cord-006664-ykfvbypo	50	20	dying	die	VBG
cord-006664-ykfvbypo	50	21	by	by	IN
cord-006664-ykfvbypo	50	22	necrosis	necrosis	NN
cord-006664-ykfvbypo	50	23	.	.	.
cord-006664-ykfvbypo	51	1	The	the	DT
cord-006664-ykfvbypo	51	2	destructive	destructive	JJ
cord-006664-ykfvbypo	51	3	spilling	spilling	NN
cord-006664-ykfvbypo	51	4	of	of	IN
cord-006664-ykfvbypo	51	5	intracellular	intracellular	JJ
cord-006664-ykfvbypo	51	6	contents	content	NNS
cord-006664-ykfvbypo	51	7	into	into	IN
cord-006664-ykfvbypo	51	8	the	the	DT
cord-006664-ykfvbypo	51	9	surrounding	surround	VBG
cord-006664-ykfvbypo	51	10	tissues	tissue	NNS
cord-006664-ykfvbypo	51	11	evoking	evoke	VBG
cord-006664-ykfvbypo	51	12	the	the	DT
cord-006664-ykfvbypo	51	13	classical	classical	JJ
cord-006664-ykfvbypo	51	14	inflammatory	inflammatory	JJ
cord-006664-ykfvbypo	51	15	responses	response	NNS
cord-006664-ykfvbypo	51	16	of	of	IN
cord-006664-ykfvbypo	51	17	necrosis	necrosis	NN
cord-006664-ykfvbypo	51	18	is	be	VBZ
cord-006664-ykfvbypo	51	19	absent	absent	JJ
cord-006664-ykfvbypo	51	20	in	in	IN
cord-006664-ykfvbypo	51	21	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	51	22	.	.	.
cord-006664-ykfvbypo	52	1	Apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	52	2	cells	cell	NNS
cord-006664-ykfvbypo	52	3	are	be	VBP
cord-006664-ykfvbypo	52	4	phagocytosed	phagocytose	VBN
cord-006664-ykfvbypo	52	5	by	by	IN
cord-006664-ykfvbypo	52	6	neighbouring	neighbouring	JJ
cord-006664-ykfvbypo	52	7	cells	cell	NNS
cord-006664-ykfvbypo	52	8	without	without	IN
cord-006664-ykfvbypo	52	9	the	the	DT
cord-006664-ykfvbypo	52	10	inflammation	inflammation	NN
cord-006664-ykfvbypo	52	11	associated	associate	VBN
cord-006664-ykfvbypo	52	12	with	with	IN
cord-006664-ykfvbypo	52	13	,	,	,
cord-006664-ykfvbypo	52	14	or	or	CC
cord-006664-ykfvbypo	52	15	need	need	VB
cord-006664-ykfvbypo	52	16	for	for	IN
cord-006664-ykfvbypo	52	17	,	,	,
cord-006664-ykfvbypo	52	18	neutrophil	neutrophil	NN
cord-006664-ykfvbypo	52	19	recruitment	recruitment	NN
cord-006664-ykfvbypo	52	20	.	.	.
cord-006664-ykfvbypo	53	1	'	'	''
cord-006664-ykfvbypo	53	2	-	-	.
cord-006664-ykfvbypo	54	1	'	'	''
cord-006664-ykfvbypo	55	1	The	the	DT
cord-006664-ykfvbypo	55	2	process	process	NN
cord-006664-ykfvbypo	55	3	is	be	VBZ
cord-006664-ykfvbypo	55	4	an	an	DT
cord-006664-ykfvbypo	55	5	inducible	inducible	JJ
cord-006664-ykfvbypo	55	6	phenomenon	phenomenon	NN
cord-006664-ykfvbypo	55	7	with	with	IN
cord-006664-ykfvbypo	55	8	a	a	DT
cord-006664-ykfvbypo	55	9	key	key	JJ
cord-006664-ykfvbypo	55	10	biological	biological	JJ
cord-006664-ykfvbypo	55	11	event	event	NN
cord-006664-ykfvbypo	55	12	being	be	VBG
cord-006664-ykfvbypo	55	13	the	the	DT
cord-006664-ykfvbypo	55	14	activation	activation	NN
cord-006664-ykfvbypo	55	15	of	of	IN
cord-006664-ykfvbypo	55	16	an	an	DT
cord-006664-ykfvbypo	55	17	endogenous	endogenous	JJ
cord-006664-ykfvbypo	55	18	endonuclease	endonuclease	NN
cord-006664-ykfvbypo	55	19	,	,	,
cord-006664-ykfvbypo	55	20	resulting	result	VBG
cord-006664-ykfvbypo	55	21	in	in	IN
cord-006664-ykfvbypo	55	22	internucleosomal	internucleosomal	NN
cord-006664-ykfvbypo	55	23	cleavage	cleavage	NN
cord-006664-ykfvbypo	55	24	of	of	IN
cord-006664-ykfvbypo	55	25	genomic	genomic	JJ
cord-006664-ykfvbypo	55	26	DNA	dna	NN
cord-006664-ykfvbypo	55	27	.	.	.
cord-006664-ykfvbypo	56	1	The	the	DT
cord-006664-ykfvbypo	56	2	extensive	extensive	JJ
cord-006664-ykfvbypo	56	3	nucleosomal	nucleosomal	JJ
cord-006664-ykfvbypo	56	4	DNA	dna	NN
cord-006664-ykfvbypo	56	5	fragments	fragment	NNS
cord-006664-ykfvbypo	56	6	resulting	result	VBG
cord-006664-ykfvbypo	56	7	from	from	IN
cord-006664-ykfvbypo	56	8	this	this	DT
cord-006664-ykfvbypo	56	9	endonuclease	endonuclease	NN
cord-006664-ykfvbypo	56	10	activation	activation	NN
cord-006664-ykfvbypo	56	11	are	be	VBP
cord-006664-ykfvbypo	56	12	180	180	CD
cord-006664-ykfvbypo	56	13	-	-	SYM
cord-006664-ykfvbypo	56	14	200	200	CD
cord-006664-ykfvbypo	56	15	bp	bp	NNP
cord-006664-ykfvbypo	56	16	oligonucleosomal	oligonucleosomal	NNP
cord-006664-ykfvbypo	56	17	units	unit	NNS
cord-006664-ykfvbypo	56	18	,	,	,
cord-006664-ykfvbypo	56	19	or	or	CC
cord-006664-ykfvbypo	56	20	multiples	multiple	NNS
cord-006664-ykfvbypo	56	21	thereof	thereof	RB
cord-006664-ykfvbypo	56	22	,	,	,
cord-006664-ykfvbypo	56	23	and	and	CC
cord-006664-ykfvbypo	56	24	are	be	VBP
cord-006664-ykfvbypo	56	25	a	a	DT
cord-006664-ykfvbypo	56	26	pathological	pathological	JJ
cord-006664-ykfvbypo	56	27	hallmark	hallmark	NN
cord-006664-ykfvbypo	56	28	of	of	IN
cord-006664-ykfvbypo	56	29	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	56	30	,	,	,
cord-006664-ykfvbypo	56	31	which	which	WDT
cord-006664-ykfvbypo	56	32	may	may	MD
cord-006664-ykfvbypo	56	33	be	be	VB
cord-006664-ykfvbypo	56	34	detected	detect	VBN
cord-006664-ykfvbypo	56	35	as	as	IN
cord-006664-ykfvbypo	56	36	a	a	DT
cord-006664-ykfvbypo	56	37	ladder	ladder	NN
cord-006664-ykfvbypo	56	38	on	on	IN
cord-006664-ykfvbypo	56	39	gel	gel	NN
cord-006664-ykfvbypo	56	40	electrophoresis	electrophoresis	NN
cord-006664-ykfvbypo	56	41	.	.	.
cord-006664-ykfvbypo	57	1	22	22	CD
cord-006664-ykfvbypo	57	2	Single	single	JJ
cord-006664-ykfvbypo	57	3	cell	cell	NN
cord-006664-ykfvbypo	57	4	microgel	microgel	NN
cord-006664-ykfvbypo	57	5	electrophoresis	electrophoresis	NN
cord-006664-ykfvbypo	57	6	,	,	,
cord-006664-ykfvbypo	57	7	the	the	DT
cord-006664-ykfvbypo	57	8	`	`	``
cord-006664-ykfvbypo	57	9	Comet	Comet	NNP
cord-006664-ykfvbypo	57	10	'	'	''
cord-006664-ykfvbypo	57	11	method	method	NN
cord-006664-ykfvbypo	57	12	,	,	,
cord-006664-ykfvbypo	57	13	can	can	MD
cord-006664-ykfvbypo	57	14	also	also	RB
cord-006664-ykfvbypo	57	15	demonstrate	demonstrate	VB
cord-006664-ykfvbypo	57	16	these	these	DT
cord-006664-ykfvbypo	57	17	distinctive	distinctive	JJ
cord-006664-ykfvbypo	57	18	DNA	dna	NN
cord-006664-ykfvbypo	57	19	strand	strand	NN
cord-006664-ykfvbypo	57	20	breaks	break	NNS
cord-006664-ykfvbypo	57	21	in	in	IN
cord-006664-ykfvbypo	57	22	individual	individual	JJ
cord-006664-ykfvbypo	57	23	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	57	24	cells	cell	NNS
cord-006664-ykfvbypo	57	25	by	by	IN
cord-006664-ykfvbypo	57	26	their	-PRON-	PRP$
cord-006664-ykfvbypo	57	27	migration	migration	NN
cord-006664-ykfvbypo	57	28	into	into	IN
cord-006664-ykfvbypo	57	29	a	a	DT
cord-006664-ykfvbypo	57	30	specific	specific	JJ
cord-006664-ykfvbypo	57	31	`	`	``
cord-006664-ykfvbypo	57	32	tail	tail	NN
cord-006664-ykfvbypo	57	33	'	'	``
cord-006664-ykfvbypo	57	34	pattern.23	pattern.23	NNP
cord-006664-ykfvbypo	57	35	a	a	DT
cord-006664-ykfvbypo	57	36	'	'	``
cord-006664-ykfvbypo	57	37	The	the	DT
cord-006664-ykfvbypo	57	38	specific	specific	JJ
cord-006664-ykfvbypo	57	39	cleavage	cleavage	NN
cord-006664-ykfvbypo	57	40	pattern	pattern	NN
cord-006664-ykfvbypo	57	41	of	of	IN
cord-006664-ykfvbypo	57	42	genomic	genomic	JJ
cord-006664-ykfvbypo	57	43	DNA	dna	NN
cord-006664-ykfvbypo	57	44	by	by	IN
cord-006664-ykfvbypo	57	45	endonucleases	endonuclease	NNS
cord-006664-ykfvbypo	57	46	yields	yield	NNS
cord-006664-ykfvbypo	57	47	strand	strand	NN
cord-006664-ykfvbypo	57	48	breaks	break	NNS
cord-006664-ykfvbypo	57	49	that	that	WDT
cord-006664-ykfvbypo	57	50	can	can	MD
cord-006664-ykfvbypo	57	51	be	be	VB
cord-006664-ykfvbypo	57	52	identified	identify	VBN
cord-006664-ykfvbypo	57	53	by	by	IN
cord-006664-ykfvbypo	57	54	labelling	label	VBG
cord-006664-ykfvbypo	57	55	of	of	IN
cord-006664-ykfvbypo	57	56	the	the	DT
cord-006664-ykfvbypo	57	57	free	free	JJ
cord-006664-ykfvbypo	57	58	3'-OH	3'-oh	CD
cord-006664-ykfvbypo	57	59	DNA	dna	NN
cord-006664-ykfvbypo	57	60	ends	end	NNS
cord-006664-ykfvbypo	57	61	with	with	IN
cord-006664-ykfvbypo	57	62	modified	modified	JJ
cord-006664-ykfvbypo	57	63	nucleotides	nucleotide	NNS
cord-006664-ykfvbypo	57	64	.	.	.
cord-006664-ykfvbypo	58	1	Terminal	terminal	JJ
cord-006664-ykfvbypo	58	2	deoxynucleotidyl	deoxynucleotidyl	NN
cord-006664-ykfvbypo	58	3	transferase	transferase	NNP
cord-006664-ykfvbypo	58	4	(	(	-LRB-
cord-006664-ykfvbypo	58	5	TdT	TdT	NNP
cord-006664-ykfvbypo	58	6	)	)	-RRB-
cord-006664-ykfvbypo	58	7	catalyses	catalyse	VBZ
cord-006664-ykfvbypo	58	8	polymerisation	polymerisation	NN
cord-006664-ykfvbypo	58	9	of	of	IN
cord-006664-ykfvbypo	58	10	nucleotides	nucleotide	NNS
cord-006664-ykfvbypo	58	11	to	to	TO
cord-006664-ykfvbypo	58	12	free	free	VB
cord-006664-ykfvbypo	58	13	3'-OH	3'-oh	CD
cord-006664-ykfvbypo	58	14	DNA	dna	NN
cord-006664-ykfvbypo	58	15	ends	end	NNS
cord-006664-ykfvbypo	58	16	in	in	IN
cord-006664-ykfvbypo	58	17	a	a	DT
cord-006664-ykfvbypo	58	18	template	template	NN
cord-006664-ykfvbypo	58	19	manner	manner	NN
cord-006664-ykfvbypo	58	20	in	in	IN
cord-006664-ykfvbypo	58	21	order	order	NN
cord-006664-ykfvbypo	58	22	to	to	TO
cord-006664-ykfvbypo	58	23	label	label	VB
cord-006664-ykfvbypo	58	24	these	these	DT
cord-006664-ykfvbypo	58	25	breaks	break	NNS
cord-006664-ykfvbypo	58	26	in	in	IN
cord-006664-ykfvbypo	58	27	the	the	DT
cord-006664-ykfvbypo	58	28	TUNEL	TUNEL	NNP
cord-006664-ykfvbypo	59	1	(	(	-LRB-
cord-006664-ykfvbypo	59	2	TdT	tdt	NN
cord-006664-ykfvbypo	59	3	-	-	HYPH
cord-006664-ykfvbypo	59	4	mediated	mediate	VBN
cord-006664-ykfvbypo	59	5	dUTP	dUTP	NNP
cord-006664-ykfvbypo	59	6	nick	nick	NNP
cord-006664-ykfvbypo	59	7	end	end	NNP
cord-006664-ykfvbypo	59	8	labelling	labelling	NNP
cord-006664-ykfvbypo	59	9	)	)	-RRB-
cord-006664-ykfvbypo	59	10	assay	assay	NN
cord-006664-ykfvbypo	59	11	for	for	IN
cord-006664-ykfvbypo	59	12	apoptosis.26	apoptosis.26	NN
cord-006664-ykfvbypo	59	13	'	'	''
cord-006664-ykfvbypo	60	1	The	the	DT
cord-006664-ykfvbypo	60	2	regulation	regulation	NN
cord-006664-ykfvbypo	60	3	of	of	IN
cord-006664-ykfvbypo	60	4	intracellular	intracellular	JJ
cord-006664-ykfvbypo	60	5	pH	pH	NNP
cord-006664-ykfvbypo	60	6	is	be	VBZ
cord-006664-ykfvbypo	60	7	integrated	integrate	VBN
cord-006664-ykfvbypo	60	8	into	into	IN
cord-006664-ykfvbypo	60	9	the	the	DT
cord-006664-ykfvbypo	60	10	progression	progression	NN
cord-006664-ykfvbypo	60	11	of	of	IN
cord-006664-ykfvbypo	60	12	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	60	13	,	,	,
cord-006664-ykfvbypo	60	14	with	with	IN
cord-006664-ykfvbypo	60	15	a	a	DT
cord-006664-ykfvbypo	60	16	fall	fall	NN
cord-006664-ykfvbypo	60	17	in	in	IN
cord-006664-ykfvbypo	60	18	pH	ph	NN
cord-006664-ykfvbypo	60	19	preceding	precede	VBG
cord-006664-ykfvbypo	60	20	the	the	DT
cord-006664-ykfvbypo	60	21	terminal	terminal	JJ
cord-006664-ykfvbypo	60	22	subcellular	subcellular	JJ
cord-006664-ykfvbypo	60	23	events	event	NNS
cord-006664-ykfvbypo	60	24	.	.	.
cord-006664-ykfvbypo	61	1	28	28	CD
cord-006664-ykfvbypo	61	2	Preconditioning	Preconditioning	NNP
cord-006664-ykfvbypo	61	3	of	of	IN
cord-006664-ykfvbypo	61	4	cells	cell	NNS
cord-006664-ykfvbypo	61	5	using	use	VBG
cord-006664-ykfvbypo	61	6	ischaemia	ischaemia	NN
cord-006664-ykfvbypo	61	7	protects	protect	VBZ
cord-006664-ykfvbypo	61	8	against	against	IN
cord-006664-ykfvbypo	61	9	cell	cell	NN
cord-006664-ykfvbypo	61	10	death	death	NN
cord-006664-ykfvbypo	61	11	through	through	IN
cord-006664-ykfvbypo	61	12	protein	protein	NN
cord-006664-ykfvbypo	61	13	kinase	kinase	NN
cord-006664-ykfvbypo	61	14	C	C	NNP
cord-006664-ykfvbypo	61	15	(	(	-LRB-
cord-006664-ykfvbypo	61	16	PKC	PKC	NNP
cord-006664-ykfvbypo	61	17	)	)	-RRB-
cord-006664-ykfvbypo	61	18	mechanisms.29•3	mechanisms.29•3	VBZ
cord-006664-ykfvbypo	61	19	°	°	NNP
cord-006664-ykfvbypo	62	1	The	the	DT
cord-006664-ykfvbypo	62	2	PKC	PKC	NNP
cord-006664-ykfvbypo	62	3	protective	protective	JJ
cord-006664-ykfvbypo	62	4	mechanism	mechanism	NN
cord-006664-ykfvbypo	62	5	involves	involve	VBZ
cord-006664-ykfvbypo	62	6	diminution	diminution	NN
cord-006664-ykfvbypo	62	7	of	of	IN
cord-006664-ykfvbypo	62	8	intracellular	intracellular	JJ
cord-006664-ykfvbypo	62	9	acidification	acidification	NN
cord-006664-ykfvbypo	62	10	and	and	CC
cord-006664-ykfvbypo	62	11	inhibition	inhibition	NN
cord-006664-ykfvbypo	62	12	of	of	IN
cord-006664-ykfvbypo	62	13	this	this	DT
cord-006664-ykfvbypo	62	14	pathway	pathway	NN
cord-006664-ykfvbypo	62	15	in	in	IN
cord-006664-ykfvbypo	62	16	vitro	vitro	FW
cord-006664-ykfvbypo	62	17	.	.	.
cord-006664-ykfvbypo	63	1	This	this	DT
cord-006664-ykfvbypo	63	2	has	have	VBZ
cord-006664-ykfvbypo	63	3	been	be	VBN
cord-006664-ykfvbypo	63	4	shown	show	VBN
cord-006664-ykfvbypo	63	5	to	to	TO
cord-006664-ykfvbypo	63	6	protect	protect	VB
cord-006664-ykfvbypo	63	7	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	63	8	from	from	IN
cord-006664-ykfvbypo	63	9	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	63	10	death	death	NN
cord-006664-ykfvbypo	63	11	in	in	IN
cord-006664-ykfvbypo	63	12	response	response	NN
cord-006664-ykfvbypo	63	13	-	-	HYPH
cord-006664-ykfvbypo	63	14	simulated	simulate	VBN
cord-006664-ykfvbypo	63	15	IR	IR	NNP
cord-006664-ykfvbypo	63	16	injury	injury	NN
cord-006664-ykfvbypo	63	17	.	.	.
cord-006664-ykfvbypo	64	1	30	30	CD
cord-006664-ykfvbypo	65	1	Although	although	IN
cord-006664-ykfvbypo	65	2	the	the	DT
cord-006664-ykfvbypo	65	3	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	65	4	cell	cell	NN
cord-006664-ykfvbypo	65	5	does	do	VBZ
cord-006664-ykfvbypo	65	6	not	not	RB
cord-006664-ykfvbypo	65	7	evoke	evoke	VB
cord-006664-ykfvbypo	65	8	inflammatory	inflammatory	JJ
cord-006664-ykfvbypo	65	9	responses	response	NNS
cord-006664-ykfvbypo	65	10	to	to	TO
cord-006664-ykfvbypo	65	11	stimulate	stimulate	VB
cord-006664-ykfvbypo	65	12	its	-PRON-	PRP$
cord-006664-ykfvbypo	65	13	removal	removal	NN
cord-006664-ykfvbypo	65	14	,	,	,
cord-006664-ykfvbypo	65	15	it	-PRON-	PRP
cord-006664-ykfvbypo	65	16	does	do	VBZ
cord-006664-ykfvbypo	65	17	signal	signal	VB
cord-006664-ykfvbypo	65	18	its	-PRON-	PRP$
cord-006664-ykfvbypo	65	19	death	death	NN
cord-006664-ykfvbypo	65	20	to	to	IN
cord-006664-ykfvbypo	65	21	resident	resident	JJ
cord-006664-ykfvbypo	65	22	tissue	tissue	NN
cord-006664-ykfvbypo	65	23	phagocytes	phagocyte	NNS
cord-006664-ykfvbypo	65	24	and	and	CC
cord-006664-ykfvbypo	65	25	neighbouring	neighbouring	NN
cord-006664-ykfvbypo	65	26	cells	cell	NNS
cord-006664-ykfvbypo	65	27	.	.	.
cord-006664-ykfvbypo	66	1	This	this	DT
cord-006664-ykfvbypo	66	2	is	be	VBZ
cord-006664-ykfvbypo	66	3	achieved	achieve	VBN
cord-006664-ykfvbypo	66	4	by	by	IN
cord-006664-ykfvbypo	66	5	cell	cell	NN
cord-006664-ykfvbypo	66	6	membrane	membrane	NN
cord-006664-ykfvbypo	66	7	surface	surface	NN
cord-006664-ykfvbypo	66	8	expression	expression	NN
cord-006664-ykfvbypo	66	9	of	of	IN
cord-006664-ykfvbypo	66	10	the	the	DT
cord-006664-ykfvbypo	66	11	normally	normally	RB
cord-006664-ykfvbypo	66	12	exclusively	exclusively	RB
cord-006664-ykfvbypo	66	13	cytoplasmic	cytoplasmic	JJ
cord-006664-ykfvbypo	66	14	facing	face	VBG
cord-006664-ykfvbypo	66	15	aminophospholipid	aminophospholipid	NN
cord-006664-ykfvbypo	66	16	phosphatidylserine	phosphatidylserine	NN
cord-006664-ykfvbypo	66	17	.	.	.
cord-006664-ykfvbypo	67	1	[	[	-LRB-
cord-006664-ykfvbypo	67	2	31	31	CD
cord-006664-ykfvbypo	67	3	]	]	-RRB-
cord-006664-ykfvbypo	67	4	[	[	-LRB-
cord-006664-ykfvbypo	67	5	32	32	CD
cord-006664-ykfvbypo	67	6	]	]	-RRB-
cord-006664-ykfvbypo	68	1	[	[	-LRB-
cord-006664-ykfvbypo	68	2	33	33	CD
cord-006664-ykfvbypo	68	3	]	]	-RRB-
cord-006664-ykfvbypo	69	1	This	this	DT
cord-006664-ykfvbypo	69	2	phosphatidylserine	phosphatidylserine	NN
cord-006664-ykfvbypo	69	3	extrusion	extrusion	NN
cord-006664-ykfvbypo	69	4	facilitates	facilitate	VBZ
cord-006664-ykfvbypo	69	5	phagocytic	phagocytic	JJ
cord-006664-ykfvbypo	69	6	removal	removal	NN
cord-006664-ykfvbypo	69	7	of	of	IN
cord-006664-ykfvbypo	69	8	the	the	DT
cord-006664-ykfvbypo	69	9	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	69	10	cell	cell	NN
cord-006664-ykfvbypo	69	11	.	.	.
cord-006664-ykfvbypo	70	1	It	-PRON-	PRP
cord-006664-ykfvbypo	70	2	also	also	RB
cord-006664-ykfvbypo	70	3	facilitates	facilitate	VBZ
cord-006664-ykfvbypo	70	4	phosphatidylserine	phosphatidylserine	NN
cord-006664-ykfvbypo	70	5	detecnon	detecnon	NN
cord-006664-ykfvbypo	70	6	on	on	IN
cord-006664-ykfvbypo	70	7	the	the	DT
cord-006664-ykfvbypo	70	8	cell	cell	NN
cord-006664-ykfvbypo	70	9	surface	surface	NN
cord-006664-ykfvbypo	70	10	by	by	IN
cord-006664-ykfvbypo	70	11	Annexin	Annexin	NNP
cord-006664-ykfvbypo	70	12	V	V	NNP
cord-006664-ykfvbypo	70	13	,	,	,
cord-006664-ykfvbypo	70	14	thus	thus	RB
cord-006664-ykfvbypo	70	15	allowing	allow	VBG
cord-006664-ykfvbypo	70	16	for	for	IN
cord-006664-ykfvbypo	70	17	another	another	DT
cord-006664-ykfvbypo	70	18	method	method	NN
cord-006664-ykfvbypo	70	19	of	of	IN
cord-006664-ykfvbypo	70	20	identifying	identify	VBG
cord-006664-ykfvbypo	70	21	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	70	22	cells	cell	NNS
cord-006664-ykfvbypo	70	23	.	.	.
cord-006664-ykfvbypo	71	1	TM	TM	NNP
cord-006664-ykfvbypo	72	1	As	as	IN
cord-006664-ykfvbypo	72	2	phosphatidylserine	phosphatidylserine	NN
cord-006664-ykfvbypo	72	3	surface	surface	NN
cord-006664-ykfvbypo	72	4	expression	expression	NN
cord-006664-ykfvbypo	72	5	is	be	VBZ
cord-006664-ykfvbypo	72	6	an	an	DT
cord-006664-ykfvbypo	72	7	early	early	JJ
cord-006664-ykfvbypo	72	8	event	event	NN
cord-006664-ykfvbypo	72	9	.	.	.
cord-006664-ykfvbypo	73	1	in	in	IN
cord-006664-ykfvbypo	73	2	the	the	DT
cord-006664-ykfvbypo	73	3	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	73	4	pathway	pathway	NN
cord-006664-ykfvbypo	73	5	,	,	,
cord-006664-ykfvbypo	73	6	Annexin	Annexin	NNP
cord-006664-ykfvbypo	73	7	V	V	NNP
cord-006664-ykfvbypo	73	8	labelling	labelling	NN
cord-006664-ykfvbypo	73	9	allows	allow	VBZ
cord-006664-ykfvbypo	73	10	identification	identification	NN
cord-006664-ykfvbypo	73	11	of	of	IN
cord-006664-ykfvbypo	73	12	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	73	13	cells	cell	NNS
cord-006664-ykfvbypo	73	14	at	at	IN
cord-006664-ykfvbypo	73	15	this	this	DT
cord-006664-ykfvbypo	73	16	timepoint	timepoint	NN
cord-006664-ykfvbypo	73	17	.	.	.
cord-006664-ykfvbypo	74	1	Cell	cell	NN
cord-006664-ykfvbypo	74	2	surface	surface	NN
cord-006664-ykfvbypo	74	3	phosphatidylserine	phosphatidylserine	NN
cord-006664-ykfvbypo	74	4	expression	expression	NN
cord-006664-ykfvbypo	74	5	promotes	promote	VBZ
cord-006664-ykfvbypo	74	6	thrombin	thrombin	JJ
cord-006664-ykfvbypo	74	7	generation	generation	NN
cord-006664-ykfvbypo	74	8	in	in	IN
cord-006664-ykfvbypo	74	9	vitro	vitro	FW
cord-006664-ykfvbypo	74	10	.	.	.
cord-006664-ykfvbypo	75	1	35	35	CD
cord-006664-ykfvbypo	76	1	This	this	DT
cord-006664-ykfvbypo	76	2	finding	finding	NN
cord-006664-ykfvbypo	76	3	raises	raise	VBZ
cord-006664-ykfvbypo	76	4	the	the	DT
cord-006664-ykfvbypo	76	5	possibility	possibility	NN
cord-006664-ykfvbypo	76	6	that	that	IN
cord-006664-ykfvbypo	76	7	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	76	8	seen	see	VBN
cord-006664-ykfvbypo	76	9	in	in	IN
cord-006664-ykfvbypo	76	10	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	76	11	plaques	plaque	NNS
cord-006664-ykfvbypo	76	12	may	may	MD
cord-006664-ykfvbypo	76	13	contribute	contribute	VB
cord-006664-ykfvbypo	76	14	to	to	IN
cord-006664-ykfvbypo	76	15	their	-PRON-	PRP$
cord-006664-ykfvbypo	76	16	thrombogenicity	thrombogenicity	NN
cord-006664-ykfvbypo	76	17	in	in	IN
cord-006664-ykfvbypo	76	18	vivo	vivo	NNP
cord-006664-ykfvbypo	76	19	.	.	.
cord-006664-ykfvbypo	77	1	Myocyte	Myocyte	NNP
cord-006664-ykfvbypo	77	2	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	77	3	is	be	VBZ
cord-006664-ykfvbypo	77	4	difficult	difficult	JJ
cord-006664-ykfvbypo	77	5	to	to	TO
cord-006664-ykfvbypo	77	6	recognise	recognise	VB
cord-006664-ykfvbypo	77	7	as	as	IN
cord-006664-ykfvbypo	77	8	it	-PRON-	PRP
cord-006664-ykfvbypo	77	9	affects	affect	VBZ
cord-006664-ykfvbypo	77	10	inchvidual	inchvidual	JJ
cord-006664-ykfvbypo	77	11	myocytes	myocyte	NNS
cord-006664-ykfvbypo	77	12	and	and	CC
cord-006664-ykfvbypo	77	13	is	be	VBZ
cord-006664-ykfvbypo	77	14	scattered	scatter	VBN
cord-006664-ykfvbypo	77	15	across	across	IN
cord-006664-ykfvbypo	77	16	the	the	DT
cord-006664-ykfvbypo	77	17	muscle	muscle	NN
cord-006664-ykfvbypo	77	18	or	or	CC
cord-006664-ykfvbypo	77	19	myocardium	myocardium	NN
cord-006664-ykfvbypo	77	20	.	.	.
cord-006664-ykfvbypo	78	1	The	the	DT
cord-006664-ykfvbypo	78	2	process	process	NN
cord-006664-ykfvbypo	78	3	of	of	IN
cord-006664-ykfvbypo	78	4	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	78	5	is	be	VBZ
cord-006664-ykfvbypo	78	6	rapidly	rapidly	RB
cord-006664-ykfvbypo	78	7	completed	complete	VBN
cord-006664-ykfvbypo	78	8	in	in	IN
cord-006664-ykfvbypo	78	9	as	as	RB
cord-006664-ykfvbypo	78	10	little	little	JJ
cord-006664-ykfvbypo	78	11	as	as	IN
cord-006664-ykfvbypo	78	12	34	34	CD
cord-006664-ykfvbypo	78	13	minutes	minute	NNS
cord-006664-ykfvbypo	78	14	(	(	-LRB-
cord-006664-ykfvbypo	78	15	as	as	IN
cord-006664-ykfvbypo	78	16	assessed	assess	VBN
cord-006664-ykfvbypo	78	17	by	by	IN
cord-006664-ykfvbypo	78	18	time	time	NN
cord-006664-ykfvbypo	78	19	lapse	lapse	NN
cord-006664-ykfvbypo	78	20	photography	photography	NNP
cord-006664-ykfvbypo	78	21	'	'	''
cord-006664-ykfvbypo	78	22	'	'	''
cord-006664-ykfvbypo	78	23	)	)	-RRB-
cord-006664-ykfvbypo	78	24	and	and	CC
cord-006664-ykfvbypo	78	25	may	may	MD
cord-006664-ykfvbypo	78	26	not	not	RB
cord-006664-ykfvbypo	78	27	be	be	VB
cord-006664-ykfvbypo	78	28	detectable	detectable	JJ
cord-006664-ykfvbypo	78	29	beyond	beyond	IN
cord-006664-ykfvbypo	78	30	24	24	CD
cord-006664-ykfvbypo	78	31	hours	hour	NNS
cord-006664-ykfvbypo	78	32	.	.	.
cord-006664-ykfvbypo	79	1	'	'	``
cord-006664-ykfvbypo	79	2	#	#	$
cord-006664-ykfvbypo	79	3	-	-	.
cord-006664-ykfvbypo	80	1	"	"	``
cord-006664-ykfvbypo	80	2	Given	give	VBN
cord-006664-ykfvbypo	80	3	this	this	DT
cord-006664-ykfvbypo	80	4	fact	fact	NN
cord-006664-ykfvbypo	80	5	,	,	,
cord-006664-ykfvbypo	80	6	the	the	DT
cord-006664-ykfvbypo	80	7	detection	detection	NN
cord-006664-ykfvbypo	80	8	of	of	IN
cord-006664-ykfvbypo	80	9	a	a	DT
cord-006664-ykfvbypo	80	10	relatively	relatively	RB
cord-006664-ykfvbypo	80	11	low	low	JJ
cord-006664-ykfvbypo	80	12	prevalence	prevalence	NN
cord-006664-ykfvbypo	80	13	(	(	-LRB-
cord-006664-ykfvbypo	80	14	0.2	0.2	CD
cord-006664-ykfvbypo	80	15	%	%	NN
cord-006664-ykfvbypo	80	16	)	)	-RRB-
cord-006664-ykfvbypo	80	17	of	of	IN
cord-006664-ykfvbypo	80	18	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	80	19	myocytes	myocyte	NNS
cord-006664-ykfvbypo	80	20	in	in	IN
cord-006664-ykfvbypo	80	21	the	the	DT
cord-006664-ykfvbypo	80	22	myocardium	myocardium	NN
cord-006664-ykfvbypo	80	23	at	at	IN
cord-006664-ykfvbypo	80	24	a	a	DT
cord-006664-ykfvbypo	80	25	given	give	VBN
cord-006664-ykfvbypo	80	26	time	time	NN
cord-006664-ykfvbypo	80	27	point	point	NN
cord-006664-ykfvbypo	80	28	is	be	VBZ
cord-006664-ykfvbypo	80	29	highly	highly	RB
cord-006664-ykfvbypo	80	30	significant	significant	JJ
cord-006664-ykfvbypo	80	31	,	,	,
cord-006664-ykfvbypo	80	32	implying	imply	VBG
cord-006664-ykfvbypo	80	33	that	that	IN
cord-006664-ykfvbypo	80	34	if	if	IN
cord-006664-ykfvbypo	80	35	sustained	sustain	VBN
cord-006664-ykfvbypo	80	36	for	for	IN
cord-006664-ykfvbypo	80	37	one	one	CD
cord-006664-ykfvbypo	80	38	year	year	NN
cord-006664-ykfvbypo	80	39	this	this	DT
cord-006664-ykfvbypo	80	40	would	would	MD
cord-006664-ykfvbypo	80	41	lead	lead	VB
cord-006664-ykfvbypo	80	42	to	to	IN
cord-006664-ykfvbypo	80	43	an	an	DT
cord-006664-ykfvbypo	80	44	unsustainable	unsustainable	JJ
cord-006664-ykfvbypo	80	45	loss	loss	NN
cord-006664-ykfvbypo	80	46	of	of	IN
cord-006664-ykfvbypo	80	47	more	more	JJR
cord-006664-ykfvbypo	80	48	than	than	IN
cord-006664-ykfvbypo	80	49	50	50	CD
cord-006664-ykfvbypo	80	50	%	%	NN
cord-006664-ykfvbypo	80	51	of	of	IN
cord-006664-ykfvbypo	80	52	the	the	DT
cord-006664-ykfvbypo	80	53	myocardium	myocardium	NN
cord-006664-ykfvbypo	80	54	.	.	.
cord-006664-ykfvbypo	81	1	Various	various	JJ
cord-006664-ykfvbypo	81	2	investigators	investigator	NNS
cord-006664-ykfvbypo	81	3	have	have	VBP
cord-006664-ykfvbypo	81	4	reported	report	VBN
cord-006664-ykfvbypo	81	5	great	great	JJ
cord-006664-ykfvbypo	81	6	variability	variability	NN
cord-006664-ykfvbypo	81	7	in	in	IN
cord-006664-ykfvbypo	81	8	the	the	DT
cord-006664-ykfvbypo	81	9	extent	extent	NN
cord-006664-ykfvbypo	81	10	of	of	IN
cord-006664-ykfvbypo	81	11	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	81	12	in	in	IN
cord-006664-ykfvbypo	81	13	diseased	diseased	JJ
cord-006664-ykfvbypo	81	14	myocardium	myocardium	NN
cord-006664-ykfvbypo	81	15	,	,	,
cord-006664-ykfvbypo	81	16	some	some	DT
cord-006664-ykfvbypo	81	17	reporting	reporting	NN
cord-006664-ykfvbypo	81	18	as	as	RB
cord-006664-ykfvbypo	81	19	high	high	JJ
cord-006664-ykfvbypo	81	20	as	as	IN
cord-006664-ykfvbypo	81	21	35	35	CD
cord-006664-ykfvbypo	81	22	%	%	NN
cord-006664-ykfvbypo	81	23	in	in	IN
cord-006664-ykfvbypo	81	24	ischaemic	ischaemic	JJ
cord-006664-ykfvbypo	81	25	cardiomyopathies	cardiomyopathy	NNS
cord-006664-ykfvbypo	81	26	.	.	.
cord-006664-ykfvbypo	81	27	'	'	''
cord-006664-ykfvbypo	82	1	°	°	NNP
cord-006664-ykfvbypo	83	1	The	the	DT
cord-006664-ykfvbypo	83	2	immunohistochemical	immunohistochemical	JJ
cord-006664-ykfvbypo	83	3	finding	finding	NN
cord-006664-ykfvbypo	83	4	of	of	IN
cord-006664-ykfvbypo	83	5	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	83	6	in	in	IN
cord-006664-ykfvbypo	83	7	the	the	DT
cord-006664-ykfvbypo	83	8	myocardium	myocardium	NN
cord-006664-ykfvbypo	83	9	can	can	MD
cord-006664-ykfvbypo	83	10	be	be	VB
cord-006664-ykfvbypo	83	11	further	further	RB
cord-006664-ykfvbypo	83	12	verified	verify	VBN
cord-006664-ykfvbypo	83	13	by	by	IN
cord-006664-ykfvbypo	83	14	demonstrating	demonstrate	VBG
cord-006664-ykfvbypo	83	15	DNA	dna	NN
cord-006664-ykfvbypo	83	16	laddering	laddering	NN
cord-006664-ykfvbypo	83	17	on	on	IN
cord-006664-ykfvbypo	83	18	electrophoresis	electrophoresis	NN
cord-006664-ykfvbypo	83	19	of	of	IN
cord-006664-ykfvbypo	83	20	comparable	comparable	JJ
cord-006664-ykfvbypo	83	21	specimens	specimen	NNS
cord-006664-ykfvbypo	83	22	.	.	.
cord-006664-ykfvbypo	84	1	16	16	CD
cord-006664-ykfvbypo	84	2	Biochemical	biochemical	JJ
cord-006664-ykfvbypo	84	3	control	control	NN
cord-006664-ykfvbypo	84	4	of	of	IN
cord-006664-ykfvbypo	84	5	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	85	1	The	the	DT
cord-006664-ykfvbypo	85	2	process	process	NN
cord-006664-ykfvbypo	85	3	of	of	IN
cord-006664-ykfvbypo	85	4	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	85	5	is	be	VBZ
cord-006664-ykfvbypo	85	6	orchestrated	orchestrate	VBN
cord-006664-ykfvbypo	85	7	by	by	IN
cord-006664-ykfvbypo	85	8	the	the	DT
cord-006664-ykfvbypo	85	9	interactions	interaction	NNS
cord-006664-ykfvbypo	85	10	of	of	IN
cord-006664-ykfvbypo	85	11	numerous	numerous	JJ
cord-006664-ykfvbypo	85	12	proto	proto	JJ
cord-006664-ykfvbypo	85	13	-	-	HYPH
cord-006664-ykfvbypo	85	14	oncogenes	oncogene	NNS
cord-006664-ykfvbypo	85	15	and	and	CC
cord-006664-ykfvbypo	85	16	environmental	environmental	JJ
cord-006664-ykfvbypo	85	17	factors	factor	NNS
cord-006664-ykfvbypo	85	18	.	.	.
cord-006664-ykfvbypo	86	1	Initial	initial	JJ
cord-006664-ykfvbypo	86	2	clues	clue	NNS
cord-006664-ykfvbypo	86	3	about	about	IN
cord-006664-ykfvbypo	86	4	the	the	DT
cord-006664-ykfvbypo	86	5	genetic	genetic	JJ
cord-006664-ykfvbypo	86	6	command	command	NN
cord-006664-ykfvbypo	86	7	structure	structure	NN
cord-006664-ykfvbypo	86	8	of	of	IN
cord-006664-ykfvbypo	86	9	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	86	10	were	be	VBD
cord-006664-ykfvbypo	86	11	gained	gain	VBN
cord-006664-ykfvbypo	86	12	from	from	IN
cord-006664-ykfvbypo	86	13	landmark	landmark	NN
cord-006664-ykfvbypo	86	14	studies	study	NNS
cord-006664-ykfvbypo	86	15	on	on	IN
cord-006664-ykfvbypo	86	16	the	the	DT
cord-006664-ykfvbypo	86	17	tiny	tiny	JJ
cord-006664-ykfvbypo	86	18	nematode	nematode	NN
cord-006664-ykfvbypo	86	19	Caenorhabditis	Caenorhabditis	NNP
cord-006664-ykfvbypo	86	20	elegans	elegan	NNS
cord-006664-ykfvbypo	86	21	showing	show	VBG
cord-006664-ykfvbypo	86	22	that	that	IN
cord-006664-ykfvbypo	86	23	there	there	EX
cord-006664-ykfvbypo	86	24	are	be	VBP
cord-006664-ykfvbypo	86	25	1,090	1,090	CD
cord-006664-ykfvbypo	86	26	cell	cell	NN
cord-006664-ykfvbypo	86	27	births	birth	NNS
cord-006664-ykfvbypo	86	28	and	and	CC
cord-006664-ykfvbypo	86	29	131	131	CD
cord-006664-ykfvbypo	86	30	cell	cell	NN
cord-006664-ykfvbypo	86	31	deaths	death	NNS
cord-006664-ykfvbypo	86	32	in	in	IN
cord-006664-ykfvbypo	86	33	the	the	DT
cord-006664-ykfvbypo	86	34	construction	construction	NN
cord-006664-ykfvbypo	86	35	of	of	IN
cord-006664-ykfvbypo	86	36	the	the	DT
cord-006664-ykfvbypo	86	37	adult	adult	NN
cord-006664-ykfvbypo	86	38	worm	worm	NN
cord-006664-ykfvbypo	86	39	.	.	.
cord-006664-ykfvbypo	87	1	`	`	''
cord-006664-ykfvbypo	87	2	-`2	-`2	.
cord-006664-ykfvbypo	88	1	Further	further	JJ
cord-006664-ykfvbypo	88	2	work	work	NN
cord-006664-ykfvbypo	88	3	identified	identify	VBD
cord-006664-ykfvbypo	88	4	two	two	CD
cord-006664-ykfvbypo	88	5	genes	gene	NNS
cord-006664-ykfvbypo	89	1	ced-3	ced-3	NNP
cord-006664-ykfvbypo	89	2	and	and	CC
cord-006664-ykfvbypo	90	1	ced-4	ced-4	LS
cord-006664-ykfvbypo	90	2	which	which	WDT
cord-006664-ykfvbypo	90	3	are	be	VBP
cord-006664-ykfvbypo	90	4	essential	essential	JJ
cord-006664-ykfvbypo	90	5	for	for	IN
cord-006664-ykfvbypo	90	6	the	the	DT
cord-006664-ykfvbypo	90	7	programmed	program	VBN
cord-006664-ykfvbypo	90	8	death	death	NN
cord-006664-ykfvbypo	90	9	of	of	IN
cord-006664-ykfvbypo	90	10	these	these	DT
cord-006664-ykfvbypo	90	11	131	131	CD
cord-006664-ykfvbypo	90	12	cells	cell	NNS
cord-006664-ykfvbypo	90	13	.	.	.
cord-006664-ykfvbypo	91	1	Mutations	mutation	NNS
cord-006664-ykfvbypo	91	2	of	of	IN
cord-006664-ykfvbypo	91	3	these	these	DT
cord-006664-ykfvbypo	91	4	genes	gene	NNS
cord-006664-ykfvbypo	91	5	permit	permit	VBP
cord-006664-ykfvbypo	91	6	these	these	DT
cord-006664-ykfvbypo	91	7	cells	cell	NNS
cord-006664-ykfvbypo	91	8	,	,	,
cord-006664-ykfvbypo	91	9	which	which	WDT
cord-006664-ykfvbypo	91	10	would	would	MD
cord-006664-ykfvbypo	91	11	normally	normally	RB
cord-006664-ykfvbypo	91	12	die	die	VB
cord-006664-ykfvbypo	91	13	,	,	,
cord-006664-ykfvbypo	91	14	to	to	TO
cord-006664-ykfvbypo	91	15	survive	survive	VB
cord-006664-ykfvbypo	91	16	.	.	.
cord-006664-ykfvbypo	92	1	A	a	DT
cord-006664-ykfvbypo	92	2	third	third	JJ
cord-006664-ykfvbypo	92	3	gene	gene	NN
cord-006664-ykfvbypo	92	4	,	,	,
cord-006664-ykfvbypo	92	5	ced-9	ced-9	NNP
cord-006664-ykfvbypo	92	6	,	,	,
cord-006664-ykfvbypo	92	7	is	be	VBZ
cord-006664-ykfvbypo	92	8	necessary	necessary	JJ
cord-006664-ykfvbypo	92	9	to	to	TO
cord-006664-ykfvbypo	92	10	sustain	sustain	VB
cord-006664-ykfvbypo	92	11	life	life	NN
cord-006664-ykfvbypo	92	12	through	through	IN
cord-006664-ykfvbypo	92	13	tonic	tonic	JJ
cord-006664-ykfvbypo	92	14	inhibition	inhibition	NN
cord-006664-ykfvbypo	92	15	of	of	IN
cord-006664-ykfvbypo	92	16	the	the	DT
cord-006664-ykfvbypo	92	17	.	.	.
cord-006664-ykfvbypo	92	18	pro	pro	JJ
cord-006664-ykfvbypo	92	19	-	-	JJ
cord-006664-ykfvbypo	92	20	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	92	21	genes	gene	NNS
cord-006664-ykfvbypo	93	1	ced-3	ced-3	NNP
cord-006664-ykfvbypo	93	2	and	and	CC
cord-006664-ykfvbypo	93	3	ced-4	ced-4	ADD
cord-006664-ykfvbypo	93	4	.	.	.
cord-006664-ykfvbypo	94	1	43	43	CD
cord-006664-ykfvbypo	95	1	The	the	DT
cord-006664-ykfvbypo	95	2	ced-9	ced-9	NNP
cord-006664-ykfvbypo	95	3	gene	gene	NN
cord-006664-ykfvbypo	95	4	shares	share	VBZ
cord-006664-ykfvbypo	95	5	structural	structural	JJ
cord-006664-ykfvbypo	95	6	and	and	CC
cord-006664-ykfvbypo	95	7	functional	functional	JJ
cord-006664-ykfvbypo	95	8	homology	homology	NN
cord-006664-ykfvbypo	95	9	with	with	IN
cord-006664-ykfvbypo	95	10	the	the	DT
cord-006664-ykfvbypo	95	11	human	human	JJ
cord-006664-ykfvbypo	95	12	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	95	13	gene	gene	NN
cord-006664-ykfvbypo	95	14	.	.	.
cord-006664-ykfvbypo	96	1	The	the	DT
cord-006664-ykfvbypo	96	2	C.	C.	NNP
cord-006664-ykfvbypo	96	3	elegans	elegan	NNS
cord-006664-ykfvbypo	96	4	ced-3	ced-3	NNPS
cord-006664-ykfvbypo	97	1	gene	gene	NN
cord-006664-ykfvbypo	97	2	equivalent	equivalent	JJ
cord-006664-ykfvbypo	97	3	product	product	NN
cord-006664-ykfvbypo	97	4	in	in	IN
cord-006664-ykfvbypo	97	5	humans	human	NNS
cord-006664-ykfvbypo	97	6	is	be	VBZ
cord-006664-ykfvbypo	97	7	a	a	DT
cord-006664-ykfvbypo	97	8	family	family	NN
cord-006664-ykfvbypo	97	9	of	of	IN
cord-006664-ykfvbypo	97	10	cystine	cystine	NN
cord-006664-ykfvbypo	97	11	proteases	protease	NNS
cord-006664-ykfvbypo	97	12	associated	associate	VBN
cord-006664-ykfvbypo	97	13	with	with	IN
cord-006664-ykfvbypo	97	14	interleukin	interleukin	NN
cord-006664-ykfvbypo	97	15	(	(	-LRB-
cord-006664-ykfvbypo	97	16	IL	IL	NNP
cord-006664-ykfvbypo	97	17	)	)	-RRB-
cord-006664-ykfvbypo	97	18	1Bconverting	1bconverting	NN
cord-006664-ykfvbypo	97	19	enzyme	enzyme	NN
cord-006664-ykfvbypo	97	20	(	(	-LRB-
cord-006664-ykfvbypo	97	21	ICE	ice	NN
cord-006664-ykfvbypo	97	22	)	)	-RRB-
cord-006664-ykfvbypo	97	23	.	.	.
cord-006664-ykfvbypo	98	1	These	these	DT
cord-006664-ykfvbypo	98	2	cystine	cystine	NN
cord-006664-ykfvbypo	98	3	proteases	protease	NNS
cord-006664-ykfvbypo	98	4	,	,	,
cord-006664-ykfvbypo	98	5	referred	refer	VBD
cord-006664-ykfvbypo	98	6	to	to	IN
cord-006664-ykfvbypo	98	7	as	as	IN
cord-006664-ykfvbypo	98	8	caspases	caspase	NNS
cord-006664-ykfvbypo	98	9	,	,	,
cord-006664-ykfvbypo	98	10	are	be	VBP
cord-006664-ykfvbypo	98	11	key	key	JJ
cord-006664-ykfvbypo	98	12	mediators	mediator	NNS
cord-006664-ykfvbypo	98	13	of	of	IN
cord-006664-ykfvbypo	98	14	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	98	15	.	.	.
cord-006664-ykfvbypo	98	16	'	'	''
cord-006664-ykfvbypo	98	17	,	,	,
cord-006664-ykfvbypo	98	18	"	"	''
cord-006664-ykfvbypo	98	19	A	a	DT
cord-006664-ykfvbypo	98	20	characteristic	characteristic	JJ
cord-006664-ykfvbypo	98	21	feature	feature	NN
cord-006664-ykfvbypo	98	22	of	of	IN
cord-006664-ykfvbypo	98	23	the	the	DT
cord-006664-ykfvbypo	98	24	caspases	caspase	NNS
cord-006664-ykfvbypo	98	25	(	(	-LRB-
cord-006664-ykfvbypo	98	26	of	of	IN
cord-006664-ykfvbypo	98	27	which	which	WDT
cord-006664-ykfvbypo	98	28	10	10	CD
cord-006664-ykfvbypo	98	29	have	have	VBP
cord-006664-ykfvbypo	98	30	been	be	VBN
cord-006664-ykfvbypo	98	31	identified	identify	VBN
cord-006664-ykfvbypo	98	32	to	to	IN
cord-006664-ykfvbypo	98	33	date	date	NN
cord-006664-ykfvbypo	98	34	)	)	-RRB-
cord-006664-ykfvbypo	98	35	is	be	VBZ
cord-006664-ykfvbypo	98	36	the	the	DT
cord-006664-ykfvbypo	98	37	presence	presence	NN
cord-006664-ykfvbypo	98	38	of	of	IN
cord-006664-ykfvbypo	98	39	a	a	DT
cord-006664-ykfvbypo	98	40	cysteine	cysteine	NN
cord-006664-ykfvbypo	98	41	residue	residue	NN
cord-006664-ykfvbypo	98	42	within	within	IN
cord-006664-ykfvbypo	98	43	a	a	DT
cord-006664-ykfvbypo	98	44	highly	highly	RB
cord-006664-ykfvbypo	98	45	conserved	conserved	JJ
cord-006664-ykfvbypo	98	46	pentameric	pentameric	NN
cord-006664-ykfvbypo	98	47	sequence	sequence	NN
cord-006664-ykfvbypo	98	48	in	in	IN
cord-006664-ykfvbypo	98	49	the	the	DT
cord-006664-ykfvbypo	98	50	catalytic	catalytic	JJ
cord-006664-ykfvbypo	98	51	centre	centre	NN
cord-006664-ykfvbypo	98	52	.	.	.
cord-006664-ykfvbypo	99	1	39	39	CD
cord-006664-ykfvbypo	99	2	'	'	''
cord-006664-ykfvbypo	100	1	The	the	DT
cord-006664-ykfvbypo	100	2	caspase	caspase	NN
cord-006664-ykfvbypo	100	3	family	family	NN
cord-006664-ykfvbypo	100	4	appears	appear	VBZ
cord-006664-ykfvbypo	100	5	to	to	TO
cord-006664-ykfvbypo	100	6	play	play	VB
cord-006664-ykfvbypo	100	7	a	a	DT
cord-006664-ykfvbypo	100	8	key	key	JJ
cord-006664-ykfvbypo	100	9	role	role	NN
cord-006664-ykfvbypo	100	10	in	in	IN
cord-006664-ykfvbypo	100	11	the	the	DT
cord-006664-ykfvbypo	100	12	initiation	initiation	NN
cord-006664-ykfvbypo	100	13	of	of	IN
cord-006664-ykfvbypo	100	14	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	100	15	cell	cell	NN
cord-006664-ykfvbypo	100	16	death	death	NN
cord-006664-ykfvbypo	100	17	,	,	,
cord-006664-ykfvbypo	100	18	being	be	VBG
cord-006664-ykfvbypo	100	19	present	present	JJ
cord-006664-ykfvbypo	100	20	during	during	IN
cord-006664-ykfvbypo	100	21	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	100	22	and	and	CC
cord-006664-ykfvbypo	100	23	their	-PRON-	PRP$
cord-006664-ykfvbypo	100	24	inhibitors	inhibitor	NNS
cord-006664-ykfvbypo	100	25	protecting	protect	VBG
cord-006664-ykfvbypo	100	26	against	against	IN
cord-006664-ykfvbypo	100	27	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	100	28	cell	cell	NN
cord-006664-ykfvbypo	100	29	death	death	NN
cord-006664-ykfvbypo	100	30	.	.	.
cord-006664-ykfvbypo	101	1	Caspase	Caspase	NNP
cord-006664-ykfvbypo	101	2	activation	activation	NN
cord-006664-ykfvbypo	101	3	produces	produce	VBZ
cord-006664-ykfvbypo	101	4	the	the	DT
cord-006664-ykfvbypo	101	5	structural	structural	JJ
cord-006664-ykfvbypo	101	6	nuclear	nuclear	JJ
cord-006664-ykfvbypo	101	7	changes	change	NNS
cord-006664-ykfvbypo	101	8	in	in	IN
cord-006664-ykfvbypo	101	9	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	101	10	via	via	IN
cord-006664-ykfvbypo	101	11	protein	protein	NN
cord-006664-ykfvbypo	101	12	cleavage	cleavage	NN
cord-006664-ykfvbypo	101	13	of	of	IN
cord-006664-ykfvbypo	101	14	cytoskeletal	cytoskeletal	JJ
cord-006664-ykfvbypo	101	15	(	(	-LRB-
cord-006664-ykfvbypo	101	16	actin	actin	NN
cord-006664-ykfvbypo	101	17	,	,	,
cord-006664-ykfvbypo	101	18	fodrin	fodrin	NNP
cord-006664-ykfvbypo	101	19	and	and	CC
cord-006664-ykfvbypo	101	20	the	the	DT
cord-006664-ykfvbypo	101	21	familial	familial	JJ
cord-006664-ykfvbypo	101	22	polyposis	polyposis	NN
cord-006664-ykfvbypo	101	23	protein	protein	NN
cord-006664-ykfvbypo	101	24	APC	APC	NNP
cord-006664-ykfvbypo	101	25	)	)	-RRB-
cord-006664-ykfvbypo	101	26	,	,	,
cord-006664-ykfvbypo	101	27	DNA	dna	NN
cord-006664-ykfvbypo	101	28	repair	repair	NN
cord-006664-ykfvbypo	101	29	(	(	-LRB-
cord-006664-ykfvbypo	101	30	DNA	dna	NN
cord-006664-ykfvbypo	101	31	-	-	HYPH
cord-006664-ykfvbypo	101	32	PK	PK	NNP
cord-006664-ykfvbypo	101	33	,	,	,
cord-006664-ykfvbypo	101	34	PARP	PARP	NNP
cord-006664-ykfvbypo	101	35	)	)	-RRB-
cord-006664-ykfvbypo	101	36	,	,	,
cord-006664-ykfvbypo	101	37	nuclear	nuclear	JJ
cord-006664-ykfvbypo	101	38	envelope	envelope	NN
cord-006664-ykfvbypo	101	39	(	(	-LRB-
cord-006664-ykfvbypo	101	40	lamins	lamins	NNP
cord-006664-ykfvbypo	101	41	)	)	-RRB-
cord-006664-ykfvbypo	101	42	and	and	CC
cord-006664-ykfvbypo	101	43	cell	cell	NN
cord-006664-ykfvbypo	101	44	cycle	cycle	NN
cord-006664-ykfvbypo	101	45	(	(	-LRB-
cord-006664-ykfvbypo	101	46	retinoblastoma	retinoblastoma	NN
cord-006664-ykfvbypo	101	47	protein	protein	NN
cord-006664-ykfvbypo	101	48	)	)	-RRB-
cord-006664-ykfvbypo	101	49	elements	element	NNS
cord-006664-ykfvbypo	101	50	.	.	.
cord-006664-ykfvbypo	101	51	'	'	''
cord-006664-ykfvbypo	102	1	In	in	IN
cord-006664-ykfvbypo	102	2	addition	addition	NN
cord-006664-ykfvbypo	102	3	,	,	,
cord-006664-ykfvbypo	102	4	one	one	CD
cord-006664-ykfvbypo	102	5	of	of	IN
cord-006664-ykfvbypo	102	6	the	the	DT
cord-006664-ykfvbypo	102	7	endonucleases	endonuclease	NNS
cord-006664-ykfvbypo	102	8	thought	think	VBN
cord-006664-ykfvbypo	102	9	to	to	TO
cord-006664-ykfvbypo	102	10	be	be	VB
cord-006664-ykfvbypo	102	11	involved	involve	VBN
cord-006664-ykfvbypo	102	12	in	in	IN
cord-006664-ykfvbypo	102	13	the	the	DT
cord-006664-ykfvbypo	102	14	chromatin	chromatin	NN
cord-006664-ykfvbypo	102	15	changes	change	NNS
cord-006664-ykfvbypo	102	16	of	of	IN
cord-006664-ykfvbypo	102	17	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	102	18	is	be	VBZ
cord-006664-ykfvbypo	102	19	activated	activate	VBN
cord-006664-ykfvbypo	102	20	by	by	IN
cord-006664-ykfvbypo	102	21	proteolytic	proteolytic	JJ
cord-006664-ykfvbypo	102	22	cleavage	cleavage	NN
cord-006664-ykfvbypo	102	23	.	.	.
cord-006664-ykfvbypo	103	1	The	the	DT
cord-006664-ykfvbypo	103	2	activation	activation	NN
cord-006664-ykfvbypo	103	3	of	of	IN
cord-006664-ykfvbypo	103	4	caspases	caspase	NNS
cord-006664-ykfvbypo	103	5	may	may	MD
cord-006664-ykfvbypo	103	6	be	be	VB
cord-006664-ykfvbypo	103	7	initiated	initiate	VBN
cord-006664-ykfvbypo	103	8	via	via	IN
cord-006664-ykfvbypo	103	9	receptordependent	receptordependent	NN
cord-006664-ykfvbypo	103	10	mechanisms	mechanism	NNS
cord-006664-ykfvbypo	103	11	,	,	,
cord-006664-ykfvbypo	103	12	specifically	specifically	RB
cord-006664-ykfvbypo	103	13	Fas	Fas	NNP
cord-006664-ykfvbypo	103	14	for	for	IN
cord-006664-ykfvbypo	103	15	two	two	CD
cord-006664-ykfvbypo	103	16	members	member	NNS
cord-006664-ykfvbypo	103	17	of	of	IN
cord-006664-ykfvbypo	103	18	the	the	DT
cord-006664-ykfvbypo	103	19	family	family	NN
cord-006664-ykfvbypo	103	20	,	,	,
cord-006664-ykfvbypo	103	21	caspase-2	caspase-2	NNP
cord-006664-ykfvbypo	103	22	and	and	CC
cord-006664-ykfvbypo	103	23	-8.4	-8.4	NNP
cord-006664-ykfvbypo	103	24	'	'	''
cord-006664-ykfvbypo	103	25	-	-	:
cord-006664-ykfvbypo	103	26	{	{	-LRB-
cord-006664-ykfvbypo	103	27	'	'	``
cord-006664-ykfvbypo	103	28	Tumour	tumour	NN
cord-006664-ykfvbypo	103	29	necrosis	necrosis	NN
cord-006664-ykfvbypo	103	30	factor	factor	NN
cord-006664-ykfvbypo	103	31	(	(	-LRB-
cord-006664-ykfvbypo	103	32	TNF	TNF	NNP
cord-006664-ykfvbypo	103	33	)	)	-RRB-
cord-006664-ykfvbypo	103	34	and	and	CC
cord-006664-ykfvbypo	103	35	Fas	Fas	NNP
cord-006664-ykfvbypo	103	36	ligand	ligand	NN
cord-006664-ykfvbypo	103	37	-	-	HYPH
cord-006664-ykfvbypo	103	38	mediated	mediate	VBN
cord-006664-ykfvbypo	103	39	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	103	40	death	death	NN
cord-006664-ykfvbypo	103	41	rely	rely	VBP
cord-006664-ykfvbypo	103	42	upon	upon	IN
cord-006664-ykfvbypo	103	43	caspase	caspase	NN
cord-006664-ykfvbypo	103	44	activation	activation	NN
cord-006664-ykfvbypo	103	45	as	as	IN
cord-006664-ykfvbypo	103	46	a	a	DT
cord-006664-ykfvbypo	103	47	prerequisite	prerequisite	NN
cord-006664-ykfvbypo	103	48	to	to	IN
cord-006664-ykfvbypo	103	49	cell	cell	NN
cord-006664-ykfvbypo	103	50	deletion	deletion	NN
cord-006664-ykfvbypo	103	51	.	.	.
cord-006664-ykfvbypo	103	52	'	'	''
cord-006664-ykfvbypo	103	53	'	'	''
cord-006664-ykfvbypo	104	1	There	there	EX
cord-006664-ykfvbypo	104	2	are	be	VBP
cord-006664-ykfvbypo	104	3	a	a	DT
cord-006664-ykfvbypo	104	4	number	number	NN
cord-006664-ykfvbypo	104	5	of	of	IN
cord-006664-ykfvbypo	104	6	characterised	characterise	VBN
cord-006664-ykfvbypo	104	7	death	death	NN
cord-006664-ykfvbypo	104	8	receptors	receptor	NNS
cord-006664-ykfvbypo	104	9	,	,	,
cord-006664-ykfvbypo	104	10	including	include	VBG
cord-006664-ykfvbypo	104	11	Fas	Fas	NNP
cord-006664-ykfvbypo	104	12	,	,	,
cord-006664-ykfvbypo	104	13	TNFRI	TNFRI	NNP
cord-006664-ykfvbypo	104	14	,	,	,
cord-006664-ykfvbypo	104	15	death	death	NN
cord-006664-ykfvbypo	104	16	receptor	receptor	NN
cord-006664-ykfvbypo	104	17	(	(	-LRB-
cord-006664-ykfvbypo	104	18	DR)-3	DR)-3	NNP
cord-006664-ykfvbypo	104	19	(	(	-LRB-
cord-006664-ykfvbypo	104	20	Apo-3	Apo-3	NNP
cord-006664-ykfvbypo	104	21	)	)	-RRB-
cord-006664-ykfvbypo	104	22	and	and	CC
cord-006664-ykfvbypo	104	23	TNF	tnf	NN
cord-006664-ykfvbypo	104	24	-	-	HYPH
cord-006664-ykfvbypo	104	25	related	relate	VBN
cord-006664-ykfvbypo	104	26	,	,	,
cord-006664-ykfvbypo	104	27	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	104	28	-	-	HYPH
cord-006664-ykfvbypo	104	29	inducing	induce	VBG
cord-006664-ykfvbypo	104	30	ligand	ligand	NN
cord-006664-ykfvbypo	104	31	(	(	-LRB-
cord-006664-ykfvbypo	104	32	TRAIL	TRAIL	NNP
cord-006664-ykfvbypo	104	33	)	)	-RRB-
cord-006664-ykfvbypo	104	34	receptors	receptor	NNS
cord-006664-ykfvbypo	104	35	DR-4	DR-4	NNP
cord-006664-ykfvbypo	105	1	and	and	CC
cord-006664-ykfvbypo	105	2	-5	-5	NNP
cord-006664-ykfvbypo	105	3	.	.	.
cord-006664-ykfvbypo	106	1	Binding	bind	VBG
cord-006664-ykfvbypo	106	2	of	of	IN
cord-006664-ykfvbypo	106	3	the	the	DT
cord-006664-ykfvbypo	106	4	respective	respective	JJ
cord-006664-ykfvbypo	106	5	ligands	ligand	NNS
cord-006664-ykfvbypo	106	6	to	to	IN
cord-006664-ykfvbypo	106	7	these	these	DT
cord-006664-ykfvbypo	106	8	receptors	receptor	NNS
cord-006664-ykfvbypo	106	9	results	result	NNS
cord-006664-ykfvbypo	106	10	in	in	IN
cord-006664-ykfvbypo	106	11	recruitment	recruitment	NN
cord-006664-ykfvbypo	106	12	-of	-of	HYPH
cord-006664-ykfvbypo	106	13	dedicated	dedicate	VBN
cord-006664-ykfvbypo	106	14	intracellular	intracellular	JJ
cord-006664-ykfvbypo	106	15	adapter	adapter	NN
cord-006664-ykfvbypo	106	16	proteins	protein	NNS
cord-006664-ykfvbypo	106	17	to	to	IN
cord-006664-ykfvbypo	106	18	the	the	DT
cord-006664-ykfvbypo	106	19	cellular	cellular	JJ
cord-006664-ykfvbypo	106	20	membrane	membrane	NN
cord-006664-ykfvbypo	106	21	.	.	.
cord-006664-ykfvbypo	107	1	For	for	IN
cord-006664-ykfvbypo	107	2	TNFR1	TNFR1	NNP
cord-006664-ykfvbypo	107	3	and	and	CC
cord-006664-ykfvbypo	107	4	DR3	DR3	NNP
cord-006664-ykfvbypo	107	5	,	,	,
cord-006664-ykfvbypo	107	6	this	this	DT
cord-006664-ykfvbypo	107	7	protein	protein	NN
cord-006664-ykfvbypo	107	8	is	be	VBZ
cord-006664-ykfvbypo	107	9	TNFR	TNFR	NNP
cord-006664-ykfvbypo	107	10	associated	associate	VBD
cord-006664-ykfvbypo	107	11	death	death	NN
cord-006664-ykfvbypo	107	12	domain	domain	NN
cord-006664-ykfvbypo	107	13	protein	protein	NN
cord-006664-ykfvbypo	107	14	(	(	-LRB-
cord-006664-ykfvbypo	107	15	TRADD	TRADD	NNP
cord-006664-ykfvbypo	107	16	)	)	-RRB-
cord-006664-ykfvbypo	107	17	.	.	.
cord-006664-ykfvbypo	107	18	'	'	''
cord-006664-ykfvbypo	108	1	"	"	``
cord-006664-ykfvbypo	108	2	56	56	CD
cord-006664-ykfvbypo	108	3	Fas	Fas	NNP
cord-006664-ykfvbypo	108	4	-	-	HYPH
cord-006664-ykfvbypo	108	5	associated	associate	VBN
cord-006664-ykfvbypo	108	6	death	death	NN
cord-006664-ykfvbypo	108	7	domain	domain	NN
cord-006664-ykfvbypo	108	8	(	(	-LRB-
cord-006664-ykfvbypo	108	9	FADD	FADD	NNP
cord-006664-ykfvbypo	108	10	)	)	-RRB-
cord-006664-ykfvbypo	108	11	protein	protein	NN
cord-006664-ykfvbypo	108	12	fulfils	fulfil	VBZ
cord-006664-ykfvbypo	108	13	this	this	DT
cord-006664-ykfvbypo	108	14	role	role	NN
cord-006664-ykfvbypo	108	15	for	for	IN
cord-006664-ykfvbypo	108	16	Fas	Fas	NNP
cord-006664-ykfvbypo	108	17	and	and	CC
cord-006664-ykfvbypo	108	18	DR-4	DR-4	NNP
cord-006664-ykfvbypo	108	19	.	.	.
cord-006664-ykfvbypo	108	20	4749	4749	CD
cord-006664-ykfvbypo	109	1	These	these	DT
cord-006664-ykfvbypo	109	2	proteins	protein	NNS
cord-006664-ykfvbypo	109	3	then	then	RB
cord-006664-ykfvbypo	109	4	interact	interact	VBP
cord-006664-ykfvbypo	109	5	with	with	IN
cord-006664-ykfvbypo	109	6	caspases	caspase	NNS
cord-006664-ykfvbypo	109	7	,	,	,
cord-006664-ykfvbypo	109	8	precipitating	precipitate	VBG
cord-006664-ykfvbypo	109	9	fatal	fatal	JJ
cord-006664-ykfvbypo	109	10	cellular	cellular	JJ
cord-006664-ykfvbypo	109	11	proteolytic	proteolytic	JJ
cord-006664-ykfvbypo	109	12	cleavage	cleavage	NN
cord-006664-ykfvbypo	109	13	.	.	.
cord-006664-ykfvbypo	110	1	Work	work	NN
cord-006664-ykfvbypo	110	2	by	by	IN
cord-006664-ykfvbypo	110	3	Enari	Enari	NNP
cord-006664-ykfvbypo	110	4	et	et	FW
cord-006664-ykfvbypo	110	5	al	al	NNP
cord-006664-ykfvbypo	110	6	'	'	POS
cord-006664-ykfvbypo	110	7	°	°	NN
cord-006664-ykfvbypo	110	8	on	on	IN
cord-006664-ykfvbypo	110	9	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	110	10	induced	induce	VBN
cord-006664-ykfvbypo	110	11	by	by	IN
cord-006664-ykfvbypo	110	12	Fas	Fas	NNP
cord-006664-ykfvbypo	110	13	receptor	receptor	NN
cord-006664-ykfvbypo	110	14	interaction	interaction	NN
cord-006664-ykfvbypo	110	15	suggested	suggest	VBD
cord-006664-ykfvbypo	110	16	that	that	IN
cord-006664-ykfvbypo	110	17	the	the	DT
cord-006664-ykfvbypo	110	18	caspases	caspase	NNS
cord-006664-ykfvbypo	110	19	are	be	VBP
cord-006664-ykfvbypo	110	20	sequentially	sequentially	RB
cord-006664-ykfvbypo	110	21	activated	activate	VBN
cord-006664-ykfvbypo	110	22	.	.	.
cord-006664-ykfvbypo	111	1	The	the	DT
cord-006664-ykfvbypo	111	2	ultimately	ultimately	RB
cord-006664-ykfvbypo	111	3	lethal	lethal	JJ
cord-006664-ykfvbypo	111	4	proteolytic	proteolytic	JJ
cord-006664-ykfvbypo	111	5	effects	effect	NNS
cord-006664-ykfvbypo	111	6	of	of	IN
cord-006664-ykfvbypo	111	7	caspase	caspase	NN
cord-006664-ykfvbypo	111	8	activation	activation	NN
cord-006664-ykfvbypo	111	9	are	be	VBP
cord-006664-ykfvbypo	111	10	mediated	mediate	VBN
cord-006664-ykfvbypo	111	11	downstream	downstream	RB
cord-006664-ykfvbypo	111	12	by	by	IN
cord-006664-ykfvbypo	111	13	caspases	caspase	NNS
cord-006664-ykfvbypo	111	14	-3	-3	.
cord-006664-ykfvbypo	112	1	and	and	CC
cord-006664-ykfvbypo	112	2	-7	-7	NNP
cord-006664-ykfvbypo	112	3	.	.	.
cord-006664-ykfvbypo	112	4	39	39	CD
cord-006664-ykfvbypo	112	5	Other	other	JJ
cord-006664-ykfvbypo	112	6	upstream	upstream	JJ
cord-006664-ykfvbypo	112	7	caspases	caspase	NNS
cord-006664-ykfvbypo	112	8	with	with	IN
cord-006664-ykfvbypo	112	9	long	long	JJ
cord-006664-ykfvbypo	112	10	prodromes	prodrome	NNS
cord-006664-ykfvbypo	112	11	have	have	VBP
cord-006664-ykfvbypo	112	12	regulatory	regulatory	JJ
cord-006664-ykfvbypo	112	13	functions	function	NNS
cord-006664-ykfvbypo	112	14	.	.	.
cord-006664-ykfvbypo	112	15	"	"	''
cord-006664-ykfvbypo	113	1	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	113	2	family	family	NN
cord-006664-ykfvbypo	114	1	The	the	DT
cord-006664-ykfvbypo	114	2	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	114	3	(	(	-LRB-
cord-006664-ykfvbypo	114	4	B	b	NN
cord-006664-ykfvbypo	114	5	-	-	HYPH
cord-006664-ykfvbypo	114	6	cell	cell	NN
cord-006664-ykfvbypo	114	7	lymphoma-2	lymphoma-2	NNS
cord-006664-ykfvbypo	114	8	)	)	-RRB-
cord-006664-ykfvbypo	114	9	gene	gene	NN
cord-006664-ykfvbypo	114	10	was	be	VBD
cord-006664-ykfvbypo	114	11	isolated	isolate	VBN
cord-006664-ykfvbypo	114	12	from	from	IN
cord-006664-ykfvbypo	114	13	the	the	DT
cord-006664-ykfvbypo	114	14	breakpoint	breakpoint	NN
cord-006664-ykfvbypo	114	15	of	of	IN
cord-006664-ykfvbypo	114	16	a	a	DT
cord-006664-ykfvbypo	114	17	translocation	translocation	NN
cord-006664-ykfvbypo	114	18	between	between	IN
cord-006664-ykfvbypo	114	19	chromosomes	chromosome	NNS
cord-006664-ykfvbypo	114	20	14	14	CD
cord-006664-ykfvbypo	114	21	and	and	CC
cord-006664-ykfvbypo	114	22	18	18	CD
cord-006664-ykfvbypo	114	23	.	.	.
cord-006664-ykfvbypo	115	1	The	the	DT
cord-006664-ykfvbypo	115	2	gene	gene	NN
cord-006664-ykfvbypo	115	3	is	be	VBZ
cord-006664-ykfvbypo	115	4	found	find	VBN
cord-006664-ykfvbypo	115	5	in	in	IN
cord-006664-ykfvbypo	115	6	90	90	CD
cord-006664-ykfvbypo	115	7	%	%	NN
cord-006664-ykfvbypo	115	8	of	of	IN
cord-006664-ykfvbypo	115	9	follicular	follicular	JJ
cord-006664-ykfvbypo	115	10	lymphomas	lymphoma	NNS
cord-006664-ykfvbypo	115	11	and	and	CC
cord-006664-ykfvbypo	115	12	20	20	CD
cord-006664-ykfvbypo	115	13	%	%	NN
cord-006664-ykfvbypo	115	14	of	of	IN
cord-006664-ykfvbypo	115	15	diffuse	diffuse	JJ
cord-006664-ykfvbypo	115	16	non	non	JJ
cord-006664-ykfvbypo	115	17	-	-	JJ
cord-006664-ykfvbypo	115	18	Hodgkin	Hodgkin	NNP
cord-006664-ykfvbypo	115	19	's	's	POS
cord-006664-ykfvbypo	115	20	lymphomas.$	lymphomas.$	NNP
cord-006664-ykfvbypo	115	21	1	1	CD
cord-006664-ykfvbypo	115	22	•52	•52	CD
cord-006664-ykfvbypo	116	1	This	this	DT
cord-006664-ykfvbypo	116	2	translocation	translocation	NN
cord-006664-ykfvbypo	116	3	results	result	VBZ
cord-006664-ykfvbypo	116	4	in	in	IN
cord-006664-ykfvbypo	116	5	the	the	DT
cord-006664-ykfvbypo	116	6	bringing	bringing	NN
cord-006664-ykfvbypo	116	7	together	together	RB
cord-006664-ykfvbypo	116	8	of	of	IN
cord-006664-ykfvbypo	116	9	the	the	DT
cord-006664-ykfvbypo	116	10	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	116	11	gene	gene	NN
cord-006664-ykfvbypo	116	12	and	and	CC
cord-006664-ykfvbypo	116	13	the	the	DT
cord-006664-ykfvbypo	116	14	immunological	immunological	JJ
cord-006664-ykfvbypo	116	15	heavy	heavy	JJ
cord-006664-ykfvbypo	116	16	chain	chain	NN
cord-006664-ykfvbypo	116	17	locus	locus	NN
cord-006664-ykfvbypo	116	18	with	with	IN
cord-006664-ykfvbypo	116	19	increased	increase	VBN
cord-006664-ykfvbypo	116	20	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	116	21	production	production	NN
cord-006664-ykfvbypo	116	22	and	and	CC
cord-006664-ykfvbypo	116	23	expression	expression	NN
cord-006664-ykfvbypo	116	24	.	.	.
cord-006664-ykfvbypo	117	1	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	117	2	expression	expression	NN
cord-006664-ykfvbypo	117	3	in	in	IN
cord-006664-ykfvbypo	117	4	myeloid	myeloid	JJ
cord-006664-ykfvbypo	117	5	precursors	precursor	NNS
cord-006664-ykfvbypo	117	6	and	and	CC
cord-006664-ykfvbypo	117	7	pro	pro	JJ
cord-006664-ykfvbypo	117	8	-	-	JJ
cord-006664-ykfvbypo	117	9	B	b	JJ
cord-006664-ykfvbypo	117	10	cells	cell	NNS
cord-006664-ykfvbypo	117	11	dramatically	dramatically	RB
cord-006664-ykfvbypo	117	12	improves	improve	VBZ
cord-006664-ykfvbypo	117	13	survival	survival	NN
cord-006664-ykfvbypo	117	14	on	on	IN
cord-006664-ykfvbypo	117	15	withdrawal	withdrawal	NN
cord-006664-ykfvbypo	117	16	of	of	IN
cord-006664-ykfvbypo	117	17	growth	growth	NN
cord-006664-ykfvbypo	117	18	factors	factor	NNS
cord-006664-ykfvbypo	117	19	.	.	.
cord-006664-ykfvbypo	118	1	The	the	DT
cord-006664-ykfvbypo	118	2	C.	C.	NNP
cord-006664-ykfvbypo	118	3	elegans	elegan	NNS
cord-006664-ykfvbypo	118	4	equivalent	equivalent	JJ
cord-006664-ykfvbypo	118	5	to	to	IN
cord-006664-ykfvbypo	118	6	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	118	7	was	be	VBD
cord-006664-ykfvbypo	118	8	found	find	VBN
cord-006664-ykfvbypo	118	9	to	to	TO
cord-006664-ykfvbypo	118	10	be	be	VB
cord-006664-ykfvbypo	118	11	ced-9	ced-9	NNP
cord-006664-ykfvbypo	118	12	,	,	,
cord-006664-ykfvbypo	118	13	whose	whose	WP$
cord-006664-ykfvbypo	118	14	loss	loss	NN
cord-006664-ykfvbypo	118	15	of	of	IN
cord-006664-ykfvbypo	118	16	function	function	NN
cord-006664-ykfvbypo	118	17	mutation	mutation	NN
cord-006664-ykfvbypo	118	18	precipitated	precipitate	VBD
cord-006664-ykfvbypo	118	19	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	118	20	,	,	,
cord-006664-ykfvbypo	118	21	thus	thus	RB
cord-006664-ykfvbypo	118	22	characterising	characterise	VBG
cord-006664-ykfvbypo	118	23	it	-PRON-	PRP
cord-006664-ykfvbypo	118	24	as	as	IN
cord-006664-ykfvbypo	118	25	a	a	DT
cord-006664-ykfvbypo	118	26	negative	negative	JJ
cord-006664-ykfvbypo	118	27	regulator	regulator	NN
cord-006664-ykfvbypo	118	28	of	of	IN
cord-006664-ykfvbypo	118	29	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	118	30	.	.	.
cord-006664-ykfvbypo	119	1	53	53	CD
cord-006664-ykfvbypo	120	1	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	120	2	gene	gene	NN
cord-006664-ykfvbypo	120	3	expression	expression	NN
cord-006664-ykfvbypo	120	4	in	in	IN
cord-006664-ykfvbypo	120	5	humans	human	NNS
cord-006664-ykfvbypo	120	6	correlates	correlate	VBZ
cord-006664-ykfvbypo	120	7	with	with	IN
cord-006664-ykfvbypo	120	8	resistance	resistance	NN
cord-006664-ykfvbypo	120	9	to	to	IN
cord-006664-ykfvbypo	120	10	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	120	11	cell	cell	NN
cord-006664-ykfvbypo	120	12	death	death	NN
cord-006664-ykfvbypo	120	13	.	.	.
cord-006664-ykfvbypo	121	1	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	121	2	overexpression	overexpression	NN
cord-006664-ykfvbypo	121	3	confers	confer	VBZ
cord-006664-ykfvbypo	121	4	resistance	resistance	NN
cord-006664-ykfvbypo	121	5	to	to	IN
cord-006664-ykfvbypo	121	6	the	the	DT
cord-006664-ykfvbypo	121	7	action	action	NN
cord-006664-ykfvbypo	121	8	of	of	IN
cord-006664-ykfvbypo	121	9	gamma	gamma	NN
cord-006664-ykfvbypo	121	10	radiation	radiation	NN
cord-006664-ykfvbypo	121	11	and	and	CC
cord-006664-ykfvbypo	121	12	chemotherapeutic	chemotherapeutic	JJ
cord-006664-ykfvbypo	121	13	drugs	drug	NNS
cord-006664-ykfvbypo	121	14	that	that	WDT
cord-006664-ykfvbypo	121	15	act	act	VBP
cord-006664-ykfvbypo	121	16	by	by	IN
cord-006664-ykfvbypo	121	17	inducing	induce	VBG
cord-006664-ykfvbypo	121	18	DNA	dna	NN
cord-006664-ykfvbypo	121	19	damage	damage	NN
cord-006664-ykfvbypo	121	20	.	.	.
cord-006664-ykfvbypo	122	1	It	-PRON-	PRP
cord-006664-ykfvbypo	122	2	does	do	VBZ
cord-006664-ykfvbypo	122	3	not	not	RB
cord-006664-ykfvbypo	122	4	prevent	prevent	VB
cord-006664-ykfvbypo	122	5	damage	damage	NN
cord-006664-ykfvbypo	122	6	to	to	IN
cord-006664-ykfvbypo	122	7	the	the	DT
cord-006664-ykfvbypo	122	8	cells	cell	NNS
cord-006664-ykfvbypo	122	9	from	from	IN
cord-006664-ykfvbypo	122	10	these	these	DT
cord-006664-ykfvbypo	122	11	agents	agent	NNS
cord-006664-ykfvbypo	122	12	,	,	,
cord-006664-ykfvbypo	122	13	but	but	CC
cord-006664-ykfvbypo	122	14	rather	rather	RB
cord-006664-ykfvbypo	122	15	inhibits	inhibit	VBZ
cord-006664-ykfvbypo	122	16	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	122	17	occurring	occur	VBG
cord-006664-ykfvbypo	122	18	in	in	IN
cord-006664-ykfvbypo	122	19	response	response	NN
cord-006664-ykfvbypo	123	1	In	in	IN
cord-006664-ykfvbypo	123	2	the	the	DT
cord-006664-ykfvbypo	123	3	heart	heart	NN
cord-006664-ykfvbypo	123	4	,	,	,
cord-006664-ykfvbypo	123	5	diminished	diminish	VBD
cord-006664-ykfvbypo	123	6	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	123	7	expression	expression	NN
cord-006664-ykfvbypo	123	8	in	in	IN
cord-006664-ykfvbypo	123	9	the	the	DT
cord-006664-ykfvbypo	123	10	right	right	JJ
cord-006664-ykfvbypo	123	11	ventricle	ventricle	NN
cord-006664-ykfvbypo	123	12	has	have	VBZ
cord-006664-ykfvbypo	123	13	been	be	VBN
cord-006664-ykfvbypo	123	14	associated	associate	VBN
cord-006664-ykfvbypo	123	15	with	with	IN
cord-006664-ykfvbypo	123	16	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	123	17	cell	cell	NN
cord-006664-ykfvbypo	123	18	death	death	NN
cord-006664-ykfvbypo	123	19	assisting	assist	VBG
cord-006664-ykfvbypo	123	20	the	the	DT
cord-006664-ykfvbypo	123	21	transition	transition	NN
cord-006664-ykfvbypo	123	22	to	to	IN
cord-006664-ykfvbypo	123	23	an	an	DT
cord-006664-ykfvbypo	123	24	adult	adult	NN
cord-006664-ykfvbypo	123	25	circulatory	circulatory	NN
cord-006664-ykfvbypo	123	26	system.5	system.5	NN
cord-006664-ykfvbypo	124	1	In	in	IN
cord-006664-ykfvbypo	124	2	coronary	coronary	JJ
cord-006664-ykfvbypo	124	3	artery	artery	NN
cord-006664-ykfvbypo	124	4	ligation	ligation	NN
cord-006664-ykfvbypo	124	5	models	model	NNS
cord-006664-ykfvbypo	124	6	and	and	CC
cord-006664-ykfvbypo	124	7	in	in	IN
cord-006664-ykfvbypo	124	8	vivo	vivo	NN
cord-006664-ykfvbypo	124	9	with	with	IN
cord-006664-ykfvbypo	124	10	heart	heart	NN
cord-006664-ykfvbypo	124	11	failure	failure	NN
cord-006664-ykfvbypo	124	12	,	,	,
cord-006664-ykfvbypo	124	13	bcl-2	bcl-2	NN
cord-006664-ykfvbypo	124	14	expression	expression	NN
cord-006664-ykfvbypo	124	15	is	be	VBZ
cord-006664-ykfvbypo	124	16	markedly	markedly	RB
cord-006664-ykfvbypo	124	17	upregulated	upregulate	VBN
cord-006664-ykfvbypo	124	18	.	.	.
cord-006664-ykfvbypo	125	1	16	16	CD
cord-006664-ykfvbypo	126	1	This	this	DT
cord-006664-ykfvbypo	126	2	upregulation	upregulation	NN
cord-006664-ykfvbypo	126	3	is	be	VBZ
cord-006664-ykfvbypo	126	4	suggested	suggest	VBN
cord-006664-ykfvbypo	126	5	to	to	TO
cord-006664-ykfvbypo	126	6	be	be	VB
cord-006664-ykfvbypo	126	7	a	a	DT
cord-006664-ykfvbypo	126	8	compensatory	compensatory	JJ
cord-006664-ykfvbypo	126	9	mechanism	mechanism	NN
cord-006664-ykfvbypo	126	10	by	by	IN
cord-006664-ykfvbypo	126	11	the	the	DT
cord-006664-ykfvbypo	126	12	myocardium	myocardium	NN
cord-006664-ykfvbypo	126	13	in	in	IN
cord-006664-ykfvbypo	126	14	the	the	DT
cord-006664-ykfvbypo	126	15	face	face	NN
cord-006664-ykfvbypo	126	16	of	of	IN
cord-006664-ykfvbypo	126	17	widespread	widespread	JJ
cord-006664-ykfvbypo	126	18	cell	cell	NN
cord-006664-ykfvbypo	126	19	death	death	NN
cord-006664-ykfvbypo	126	20	.	.	.
cord-006664-ykfvbypo	127	1	The	the	DT
cord-006664-ykfvbypo	127	2	exact	exact	JJ
cord-006664-ykfvbypo	127	3	mechanism	mechanism	NN
cord-006664-ykfvbypo	127	4	whereby	whereby	WRB
cord-006664-ykfvbypo	127	5	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	127	6	inhibits	inhibit	VBZ
cord-006664-ykfvbypo	127	7	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	127	8	is	be	VBZ
cord-006664-ykfvbypo	127	9	uncertain	uncertain	JJ
cord-006664-ykfvbypo	127	10	;	;	:
cord-006664-ykfvbypo	127	11	however	however	RB
cord-006664-ykfvbypo	127	12	,	,	,
cord-006664-ykfvbypo	127	13	its	-PRON-	PRP$
cord-006664-ykfvbypo	127	14	co	co	NN
cord-006664-ykfvbypo	127	15	-	-	NN
cord-006664-ykfvbypo	127	16	localisation	localisation	NN
cord-006664-ykfvbypo	127	17	with	with	IN
cord-006664-ykfvbypo	127	18	bax	bax	NNP
cord-006664-ykfvbypo	127	19	on	on	IN
cord-006664-ykfvbypo	127	20	the	the	DT
cord-006664-ykfvbypo	127	21	mitochondrial	mitochondrial	JJ
cord-006664-ykfvbypo	127	22	membrane	membrane	NN
cord-006664-ykfvbypo	127	23	suggests	suggest	VBZ
cord-006664-ykfvbypo	127	24	this	this	DT
cord-006664-ykfvbypo	127	25	may	may	MD
cord-006664-ykfvbypo	127	26	be	be	VB
cord-006664-ykfvbypo	127	27	a	a	DT
cord-006664-ykfvbypo	127	28	key	key	JJ
cord-006664-ykfvbypo	127	29	site	site	NN
cord-006664-ykfvbypo	127	30	.	.	.
cord-006664-ykfvbypo	128	1	"	"	``
cord-006664-ykfvbypo	128	2	The	the	DT
cord-006664-ykfvbypo	128	3	release	release	NN
cord-006664-ykfvbypo	128	4	of	of	IN
cord-006664-ykfvbypo	128	5	mitochondrial	mitochondrial	JJ
cord-006664-ykfvbypo	128	6	proteins	protein	NNS
cord-006664-ykfvbypo	128	7	,	,	,
cord-006664-ykfvbypo	128	8	cytochrome	cytochrome	NN
cord-006664-ykfvbypo	128	9	c	c	NN
cord-006664-ykfvbypo	128	10	and	and	CC
cord-006664-ykfvbypo	128	11	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	128	12	-	-	HYPH
cord-006664-ykfvbypo	128	13	inducing	induce	VBG
cord-006664-ykfvbypo	128	14	factor	factor	NN
cord-006664-ykfvbypo	128	15	(	(	-LRB-
cord-006664-ykfvbypo	128	16	AIF	AIF	NNP
cord-006664-ykfvbypo	128	17	)	)	-RRB-
cord-006664-ykfvbypo	128	18	into	into	IN
cord-006664-ykfvbypo	128	19	the	the	DT
cord-006664-ykfvbypo	128	20	cytosol	cytosol	NN
cord-006664-ykfvbypo	128	21	activates	activate	VBZ
cord-006664-ykfvbypo	128	22	caspases	caspase	NNS
cord-006664-ykfvbypo	128	23	and	and	CC
cord-006664-ykfvbypo	128	24	thus	thus	RB
cord-006664-ykfvbypo	128	25	cell	cell	NN
cord-006664-ykfvbypo	128	26	death	death	NN
cord-006664-ykfvbypo	128	27	.	.	.
cord-006664-ykfvbypo	129	1	58	58	CD
cord-006664-ykfvbypo	129	2	,	,	,
cord-006664-ykfvbypo	129	3	a9	a9	NNP
cord-006664-ykfvbypo	129	4	Caspase	Caspase	NNP
cord-006664-ykfvbypo	129	5	-3	-3	NNP
cord-006664-ykfvbypo	129	6	,	,	,
cord-006664-ykfvbypo	129	7	-6	-6	NNP
cord-006664-ykfvbypo	129	8	and	and	CC
cord-006664-ykfvbypo	129	9	-7	-7	NNP
cord-006664-ykfvbypo	129	10	activation	activation	NN
cord-006664-ykfvbypo	129	11	are	be	VBP
cord-006664-ykfvbypo	129	12	downstream	downstream	JJ
cord-006664-ykfvbypo	129	13	from	from	IN
cord-006664-ykfvbypo	129	14	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	129	15	.	.	.
cord-006664-ykfvbypo	130	1	6061	6061	CD
cord-006664-ykfvbypo	131	1	However	however	RB
cord-006664-ykfvbypo	131	2	,	,	,
cord-006664-ykfvbypo	131	3	bcl-2	bcl-2	FW
cord-006664-ykfvbypo	131	4	blocks	block	VBZ
cord-006664-ykfvbypo	131	5	the	the	DT
cord-006664-ykfvbypo	131	6	release	release	NN
cord-006664-ykfvbypo	131	7	of	of	IN
cord-006664-ykfvbypo	131	8	cytochrome	cytochrome	NN
cord-006664-ykfvbypo	131	9	c	c	NN
cord-006664-ykfvbypo	131	10	and	and	CC
cord-006664-ykfvbypo	131	11	AIF	AIF	NNP
cord-006664-ykfvbypo	131	12	from	from	IN
cord-006664-ykfvbypo	131	13	mitochondria	mitochondrion	NNS
cord-006664-ykfvbypo	131	14	,	,	,
cord-006664-ykfvbypo	131	15	thus	thus	RB
cord-006664-ykfvbypo	131	16	suggesting	suggest	VBG
cord-006664-ykfvbypo	131	17	a	a	DT
cord-006664-ykfvbypo	131	18	potential	potential	JJ
cord-006664-ykfvbypo	131	19	site	site	NN
cord-006664-ykfvbypo	131	20	for	for	IN
cord-006664-ykfvbypo	131	21	its	-PRON-	PRP$
cord-006664-ykfvbypo	131	22	antiapoptotic	antiapoptotic	JJ
cord-006664-ykfvbypo	131	23	activity	activity	NN
cord-006664-ykfvbypo	131	24	.	.	.
cord-006664-ykfvbypo	132	1	62	62	CD
cord-006664-ykfvbypo	132	2	,	,	,
cord-006664-ykfvbypo	132	3	63	63	CD
cord-006664-ykfvbypo	133	1	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	133	2	has	have	VBZ
cord-006664-ykfvbypo	133	3	also	also	RB
cord-006664-ykfvbypo	133	4	been	be	VBN
cord-006664-ykfvbypo	133	5	suggested	suggest	VBN
cord-006664-ykfvbypo	133	6	to	to	TO
cord-006664-ykfvbypo	133	7	function	function	VB
cord-006664-ykfvbypo	133	8	as	as	IN
cord-006664-ykfvbypo	133	9	an	an	DT
cord-006664-ykfvbypo	133	10	anti	anti	JJ
cord-006664-ykfvbypo	133	11	-	-	JJ
cord-006664-ykfvbypo	133	12	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	133	13	agent	agent	NN
cord-006664-ykfvbypo	133	14	through	through	IN
cord-006664-ykfvbypo	133	15	its	-PRON-	PRP$
cord-006664-ykfvbypo	133	16	anti	anti	JJ
cord-006664-ykfvbypo	133	17	-	-	JJ
cord-006664-ykfvbypo	133	18	oxidative	oxidative	JJ
cord-006664-ykfvbypo	133	19	role	role	NN
cord-006664-ykfvbypo	133	20	.	.	.
cord-006664-ykfvbypo	134	1	°	°	NNP
cord-006664-ykfvbypo	134	2	'	'	''
cord-006664-ykfvbypo	135	1	However	however	RB
cord-006664-ykfvbypo	135	2	,	,	,
cord-006664-ykfvbypo	135	3	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	135	4	is	be	VBZ
cord-006664-ykfvbypo	135	5	also	also	RB
cord-006664-ykfvbypo	135	6	anti	anti	JJ
cord-006664-ykfvbypo	135	7	-	-	JJ
cord-006664-ykfvbypo	135	8	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	135	9	under	under	IN
cord-006664-ykfvbypo	135	10	anaerobic	anaerobic	JJ
cord-006664-ykfvbypo	135	11	cell	cell	NN
cord-006664-ykfvbypo	135	12	culture	culture	NN
cord-006664-ykfvbypo	135	13	conditions	condition	NNS
cord-006664-ykfvbypo	135	14	and	and	CC
cord-006664-ykfvbypo	135	15	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	135	16	occurs	occur	VBZ
cord-006664-ykfvbypo	135	17	in	in	IN
cord-006664-ykfvbypo	135	18	similar	similar	JJ
cord-006664-ykfvbypo	135	19	circumstances	circumstance	NNS
cord-006664-ykfvbypo	135	20	without	without	IN
cord-006664-ykfvbypo	135	21	reactive	reactive	JJ
cord-006664-ykfvbypo	135	22	oxygen	oxygen	NN
cord-006664-ykfvbypo	135	23	species	specie	NNS
cord-006664-ykfvbypo	135	24	being	be	VBG
cord-006664-ykfvbypo	135	25	present	present	JJ
cord-006664-ykfvbypo	136	1	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	136	2	still	still	RB
cord-006664-ykfvbypo	136	3	remains	remain	VBZ
cord-006664-ykfvbypo	136	4	protective	protective	JJ
cord-006664-ykfvbypo	136	5	.	.	.
cord-006664-ykfvbypo	137	1	65	65	CD
cord-006664-ykfvbypo	137	2	'	'	''
cord-006664-ykfvbypo	138	1	Therefore	therefore	RB
cord-006664-ykfvbypo	138	2	,	,	,
cord-006664-ykfvbypo	138	3	bcl-2	bcl-2	FW
cord-006664-ykfvbypo	138	4	can	can	MD
cord-006664-ykfvbypo	138	5	not	not	RB
cord-006664-ykfvbypo	138	6	function	function	VB
cord-006664-ykfvbypo	138	7	through	through	IN
cord-006664-ykfvbypo	138	8	purely	purely	RB
cord-006664-ykfvbypo	138	9	antioxidant	antioxidant	JJ
cord-006664-ykfvbypo	138	10	-	-	HYPH
cord-006664-ykfvbypo	138	11	dependent	dependent	JJ
cord-006664-ykfvbypo	138	12	mechanisms	mechanism	NNS
cord-006664-ykfvbypo	138	13	,	,	,
cord-006664-ykfvbypo	138	14	nor	nor	CC
cord-006664-ykfvbypo	138	15	can	can	MD
cord-006664-ykfvbypo	138	16	the	the	DT
cord-006664-ykfvbypo	138	17	generation	generation	NN
cord-006664-ykfvbypo	138	18	of	of	IN
cord-006664-ykfvbypo	138	19	reactive	reactive	JJ
cord-006664-ykfvbypo	138	20	oxygen	oxygen	NN
cord-006664-ykfvbypo	138	21	species	specie	NNS
cord-006664-ykfvbypo	138	22	be	be	VB
cord-006664-ykfvbypo	138	23	an	an	DT
cord-006664-ykfvbypo	138	24	exclusive	exclusive	JJ
cord-006664-ykfvbypo	138	25	effector	effector	NN
cord-006664-ykfvbypo	138	26	of	of	IN
cord-006664-ykfvbypo	138	27	programmed	programmed	JJ
cord-006664-ykfvbypo	138	28	cell	cell	NN
cord-006664-ykfvbypo	138	29	death	death	NN
cord-006664-ykfvbypo	138	30	.	.	.
cord-006664-ykfvbypo	139	1	13	13	CD
cord-006664-ykfvbypo	140	1	The	the	DT
cord-006664-ykfvbypo	140	2	extended	extended	JJ
cord-006664-ykfvbypo	140	3	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	140	4	family	family	NN
cord-006664-ykfvbypo	140	5	contains	contain	VBZ
cord-006664-ykfvbypo	140	6	nine	nine	CD
cord-006664-ykfvbypo	140	7	members	member	NNS
cord-006664-ykfvbypo	140	8	,	,	,
cord-006664-ykfvbypo	140	9	defined	define	VBN
cord-006664-ykfvbypo	140	10	by	by	IN
cord-006664-ykfvbypo	140	11	the	the	DT
cord-006664-ykfvbypo	140	12	presence	presence	NN
cord-006664-ykfvbypo	140	13	of	of	IN
cord-006664-ykfvbypo	140	14	three	three	CD
cord-006664-ykfvbypo	140	15	structural	structural	JJ
cord-006664-ykfvbypo	140	16	motifs	motif	NNS
cord-006664-ykfvbypo	140	17	in	in	IN
cord-006664-ykfvbypo	140	18	the	the	DT
cord-006664-ykfvbypo	140	19	protein	protein	NN
cord-006664-ykfvbypo	141	1	sequence.65'67	sequence.65'67	NNP
cord-006664-ykfvbypo	142	1	These	these	DT
cord-006664-ykfvbypo	142	2	proteins	protein	NNS
cord-006664-ykfvbypo	142	3	may	may	MD
cord-006664-ykfvbypo	142	4	be	be	VB
cord-006664-ykfvbypo	142	5	pro	pro	JJ
cord-006664-ykfvbypo	142	6	-	-	JJ
cord-006664-ykfvbypo	142	7	or	or	CC
cord-006664-ykfvbypo	142	8	anti	anti	JJ
cord-006664-ykfvbypo	142	9	-	-	JJ
cord-006664-ykfvbypo	142	10	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	142	11	and	and	CC
cord-006664-ykfvbypo	142	12	appear	appear	VBP
cord-006664-ykfvbypo	142	13	to	to	TO
cord-006664-ykfvbypo	142	14	interface	interface	NN
cord-006664-ykfvbypo	142	15	after	after	IN
cord-006664-ykfvbypo	142	16	cell	cell	NN
cord-006664-ykfvbypo	142	17	surface	surface	NN
cord-006664-ykfvbypo	142	18	signals	signal	NNS
cord-006664-ykfvbypo	142	19	induce	induce	VBP
cord-006664-ykfvbypo	142	20	caspase	caspase	NN
cord-006664-ykfvbypo	142	21	activation	activation	NN
cord-006664-ykfvbypo	142	22	.	.	.
cord-006664-ykfvbypo	143	1	Bax	Bax	NNP
cord-006664-ykfvbypo	143	2	is	be	VBZ
cord-006664-ykfvbypo	143	3	a	a	DT
cord-006664-ykfvbypo	143	4	pro	pro	JJ
cord-006664-ykfvbypo	143	5	-	-	JJ
cord-006664-ykfvbypo	143	6	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	143	7	member	member	NN
cord-006664-ykfvbypo	143	8	of	of	IN
cord-006664-ykfvbypo	143	9	this	this	DT
cord-006664-ykfvbypo	143	10	family	family	NN
cord-006664-ykfvbypo	143	11	with	with	IN
cord-006664-ykfvbypo	143	12	45	45	CD
cord-006664-ykfvbypo	143	13	%	%	NN
cord-006664-ykfvbypo	143	14	homology	homology	NN
cord-006664-ykfvbypo	143	15	to	to	IN
cord-006664-ykfvbypo	143	16	bcl-2	bcl-2	ADD
cord-006664-ykfvbypo	143	17	.	.	.
cord-006664-ykfvbypo	144	1	It	-PRON-	PRP
cord-006664-ykfvbypo	144	2	appears	appear	VBZ
cord-006664-ykfvbypo	144	3	that	that	IN
cord-006664-ykfvbypo	144	4	the	the	DT
cord-006664-ykfvbypo	144	5	formation	formation	NN
cord-006664-ykfvbypo	144	6	of	of	IN
cord-006664-ykfvbypo	144	7	Bax	Bax	NNP
cord-006664-ykfvbypo	144	8	/	/	SYM
cord-006664-ykfvbypo	144	9	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	144	10	heterodimers	heterodimer	NNS
cord-006664-ykfvbypo	144	11	is	be	VBZ
cord-006664-ykfvbypo	144	12	an	an	DT
cord-006664-ykfvbypo	144	13	important	important	JJ
cord-006664-ykfvbypo	144	14	control	control	NN
cord-006664-ykfvbypo	144	15	point	point	NN
cord-006664-ykfvbypo	144	16	in	in	IN
cord-006664-ykfvbypo	144	17	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	144	18	.	.	.
cord-006664-ykfvbypo	145	1	62	62	CD
cord-006664-ykfvbypo	146	1	Mutations	mutation	NNS
cord-006664-ykfvbypo	146	2	of	of	IN
cord-006664-ykfvbypo	146	3	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	146	4	may	may	MD
cord-006664-ykfvbypo	146	5	allow	allow	VB
cord-006664-ykfvbypo	146	6	it	-PRON-	PRP
cord-006664-ykfvbypo	146	7	to	to	TO
cord-006664-ykfvbypo	146	8	evade	evade	VB
cord-006664-ykfvbypo	146	9	the	the	DT
cord-006664-ykfvbypo	146	10	blocking	block	VBG
cord-006664-ykfvbypo	146	11	effect	effect	NN
cord-006664-ykfvbypo	146	12	of	of	IN
cord-006664-ykfvbypo	146	13	binding	bind	VBG
cord-006664-ykfvbypo	146	14	to	to	IN
cord-006664-ykfvbypo	146	15	Bax	Bax	NNP
cord-006664-ykfvbypo	146	16	and	and	CC
cord-006664-ykfvbypo	146	17	thus	thus	RB
cord-006664-ykfvbypo	146	18	allow	allow	VB
cord-006664-ykfvbypo	146	19	anti	anti	JJ
cord-006664-ykfvbypo	146	20	-	-	JJ
cord-006664-ykfvbypo	146	21	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	146	22	signals	signal	NNS
cord-006664-ykfvbypo	146	23	to	to	TO
cord-006664-ykfvbypo	146	24	assume	assume	VB
cord-006664-ykfvbypo	146	25	dominance	dominance	NN
cord-006664-ykfvbypo	146	26	within	within	IN
cord-006664-ykfvbypo	146	27	the	the	DT
cord-006664-ykfvbypo	146	28	cell	cell	NN
cord-006664-ykfvbypo	146	29	.	.	.
cord-006664-ykfvbypo	147	1	Thus	thus	RB
cord-006664-ykfvbypo	147	2	,	,	,
cord-006664-ykfvbypo	147	3	if	if	IN
cord-006664-ykfvbypo	147	4	the	the	DT
cord-006664-ykfvbypo	147	5	Bax	Bax	NNP
cord-006664-ykfvbypo	147	6	/	/	SYM
cord-006664-ykfvbypo	147	7	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	147	8	ratio	ratio	NN
cord-006664-ykfvbypo	147	9	is	be	VBZ
cord-006664-ykfvbypo	147	10	altered	alter	VBN
cord-006664-ykfvbypo	147	11	,	,	,
cord-006664-ykfvbypo	147	12	this	this	DT
cord-006664-ykfvbypo	147	13	allows	allow	VBZ
cord-006664-ykfvbypo	147	14	the	the	DT
cord-006664-ykfvbypo	147	15	dominant	dominant	JJ
cord-006664-ykfvbypo	147	16	pro	pro	JJ
cord-006664-ykfvbypo	147	17	-	-	JJ
cord-006664-ykfvbypo	147	18	or	or	CC
cord-006664-ykfvbypo	147	19	anti	anti	JJ
cord-006664-ykfvbypo	147	20	-	-	JJ
cord-006664-ykfvbypo	147	21	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	147	22	influence	influence	NN
cord-006664-ykfvbypo	147	23	to	to	TO
cord-006664-ykfvbypo	147	24	prevail	prevail	VB
cord-006664-ykfvbypo	147	25	.	.	.
cord-006664-ykfvbypo	148	1	The	the	DT
cord-006664-ykfvbypo	148	2	overexpression	overexpression	NN
cord-006664-ykfvbypo	148	3	of	of	IN
cord-006664-ykfvbypo	148	4	bcl-2	bcl-2	NN
cord-006664-ykfvbypo	148	5	and	and	CC
cord-006664-ykfvbypo	148	6	the	the	DT
cord-006664-ykfvbypo	148	7	anti	anti	JJ
cord-006664-ykfvbypo	148	8	-	-	JJ
cord-006664-ykfvbypo	148	9	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	148	10	proto	proto	JJ
cord-006664-ykfvbypo	148	11	-	-	HYPH
cord-006664-ykfvbypo	148	12	oncogene	oncogene	NN
cord-006664-ykfvbypo	148	13	bcl	bcl	NNP
cord-006664-ykfvbypo	148	14	-	-	HYPH
cord-006664-ykfvbypo	148	15	xL	xL	NNP
cord-006664-ykfvbypo	148	16	have	have	VBP
cord-006664-ykfvbypo	148	17	been	be	VBN
cord-006664-ykfvbypo	148	18	shown	show	VBN
cord-006664-ykfvbypo	148	19	to	to	TO
cord-006664-ykfvbypo	148	20	be	be	VB
cord-006664-ykfvbypo	148	21	associated	associate	VBN
cord-006664-ykfvbypo	148	22	with	with	IN
cord-006664-ykfvbypo	148	23	an	an	DT
cord-006664-ykfvbypo	148	24	alteration	alteration	NN
cord-006664-ykfvbypo	148	25	in	in	IN
cord-006664-ykfvbypo	148	26	the	the	DT
cord-006664-ykfvbypo	148	27	onset	onset	NN
cord-006664-ykfvbypo	148	28	of	of	IN
cord-006664-ykfvbypo	148	29	toxin	toxin	NN
cord-006664-ykfvbypo	148	30	-	-	HYPH
cord-006664-ykfvbypo	148	31	induced	induce	VBN
cord-006664-ykfvbypo	148	32	apoptosis.^•T	apoptosis.^•T	NNP
cord-006664-ykfvbypo	148	33	he	-PRON-	PRP
cord-006664-ykfvbypo	148	34	bcl	bcl	NNP
cord-006664-ykfvbypo	148	35	-	-	HYPH
cord-006664-ykfvbypo	148	36	x	x	NNP
cord-006664-ykfvbypo	148	37	member	member	NN
cord-006664-ykfvbypo	148	38	of	of	IN
cord-006664-ykfvbypo	148	39	this	this	DT
cord-006664-ykfvbypo	148	40	family	family	NN
cord-006664-ykfvbypo	148	41	offers	offer	VBZ
cord-006664-ykfvbypo	148	42	protection	protection	NN
cord-006664-ykfvbypo	148	43	from	from	IN
cord-006664-ykfvbypo	148	44	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	148	45	by	by	IN
cord-006664-ykfvbypo	148	46	binding	bind	VBG
cord-006664-ykfvbypo	148	47	to	to	IN
cord-006664-ykfvbypo	148	48	bax	bax	NNP
cord-006664-ykfvbypo	148	49	,	,	,
cord-006664-ykfvbypo	148	50	thus	thus	RB
cord-006664-ykfvbypo	148	51	preventing	prevent	VBG
cord-006664-ykfvbypo	148	52	the	the	DT
cord-006664-ykfvbypo	148	53	formation	formation	NN
cord-006664-ykfvbypo	148	54	of	of	IN
cord-006664-ykfvbypo	148	55	bax	bax	NNP
cord-006664-ykfvbypo	148	56	homodimers	homodimers	NNP
cord-006664-ykfvbypo	148	57	which	which	WDT
cord-006664-ykfvbypo	148	58	accelerate	accelerate	VBP
cord-006664-ykfvbypo	148	59	the	the	DT
cord-006664-ykfvbypo	148	60	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	148	61	process	process	NN
cord-006664-ykfvbypo	148	62	.	.	.
cord-006664-ykfvbypo	148	63	'	'	''
cord-006664-ykfvbypo	149	1	°	°	NNP
cord-006664-ykfvbypo	150	1	The	the	DT
cord-006664-ykfvbypo	150	2	observed	observed	JJ
cord-006664-ykfvbypo	150	3	reduction	reduction	NN
cord-006664-ykfvbypo	150	4	in	in	IN
cord-006664-ykfvbypo	150	5	bcl	bcl	NNP
cord-006664-ykfvbypo	150	6	-	-	HYPH
cord-006664-ykfvbypo	150	7	x	x	NNP
cord-006664-ykfvbypo	150	8	seen	see	VBN
cord-006664-ykfvbypo	150	9	in	in	IN
cord-006664-ykfvbypo	150	10	experimentally	experimentally	RB
cord-006664-ykfvbypo	150	11	injured	injure	VBN
cord-006664-ykfvbypo	150	12	arteries	artery	NNS
cord-006664-ykfvbypo	150	13	may	may	MD
cord-006664-ykfvbypo	150	14	therefore	therefore	RB
cord-006664-ykfvbypo	150	15	allow	allow	VB
cord-006664-ykfvbypo	150	16	bax	bax	NNP
cord-006664-ykfvbypo	150	17	homodimerisation	homodimerisation	NN
cord-006664-ykfvbypo	150	18	to	to	TO
cord-006664-ykfvbypo	150	19	occur	occur	VB
cord-006664-ykfvbypo	150	20	,	,	,
cord-006664-ykfvbypo	150	21	precipitating	precipitate	VBG
cord-006664-ykfvbypo	150	22	smooth	smooth	JJ
cord-006664-ykfvbypo	150	23	muscle	muscle	NN
cord-006664-ykfvbypo	150	24	cell	cell	NN
cord-006664-ykfvbypo	150	25	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	150	26	.	.	.
cord-006664-ykfvbypo	151	1	7	7	LS
cord-006664-ykfvbypo	151	2	'	'	``
cord-006664-ykfvbypo	151	3	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	151	4	expression	expression	NN
cord-006664-ykfvbypo	151	5	is	be	VBZ
cord-006664-ykfvbypo	151	6	markedly	markedly	RB
cord-006664-ykfvbypo	151	7	upregulated	upregulate	VBN
cord-006664-ykfvbypo	151	8	in	in	IN
cord-006664-ykfvbypo	151	9	humans	human	NNS
cord-006664-ykfvbypo	151	10	with	with	IN
cord-006664-ykfvbypo	151	11	heart	heart	NN
cord-006664-ykfvbypo	151	12	failure	failure	NN
cord-006664-ykfvbypo	151	13	.	.	.
cord-006664-ykfvbypo	152	1	However	however	RB
cord-006664-ykfvbypo	152	2	,	,	,
cord-006664-ykfvbypo	152	3	Bax	Bax	NNP
cord-006664-ykfvbypo	152	4	expression	expression	NN
cord-006664-ykfvbypo	152	5	is	be	VBZ
cord-006664-ykfvbypo	152	6	unaffected	unaffected	JJ
cord-006664-ykfvbypo	152	7	.	.	.
cord-006664-ykfvbypo	153	1	This	this	DT
cord-006664-ykfvbypo	153	2	upregulation	upregulation	NN
cord-006664-ykfvbypo	153	3	occurs	occur	VBZ
cord-006664-ykfvbypo	153	4	in	in	IN
cord-006664-ykfvbypo	153	5	the	the	DT
cord-006664-ykfvbypo	153	6	context	context	NN
cord-006664-ykfvbypo	153	7	of	of	IN
cord-006664-ykfvbypo	153	8	an	an	DT
cord-006664-ykfvbypo	153	9	increase	increase	NN
cord-006664-ykfvbypo	153	10	in	in	IN
cord-006664-ykfvbypo	153	11	cardiomyocyte	cardiomyocyte	NNP
cord-006664-ykfvbypo	153	12	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	153	13	.	.	.
cord-006664-ykfvbypo	154	1	`	`	''
cord-006664-ykfvbypo	154	2	6	6	CD
cord-006664-ykfvbypo	155	1	The	the	DT
cord-006664-ykfvbypo	155	2	increase	increase	NN
cord-006664-ykfvbypo	155	3	in	in	IN
cord-006664-ykfvbypo	155	4	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	155	5	expression	expression	NN
cord-006664-ykfvbypo	155	6	appears	appear	VBZ
cord-006664-ykfvbypo	155	7	in	in	IN
cord-006664-ykfvbypo	155	8	this	this	DT
cord-006664-ykfvbypo	155	9	context	context	NN
cord-006664-ykfvbypo	155	10	to	to	TO
cord-006664-ykfvbypo	155	11	be	be	VB
cord-006664-ykfvbypo	155	12	a	a	DT
cord-006664-ykfvbypo	155	13	secondary	secondary	JJ
cord-006664-ykfvbypo	155	14	compensatory	compensatory	JJ
cord-006664-ykfvbypo	155	15	mechanism	mechanism	NN
cord-006664-ykfvbypo	155	16	to	to	TO
cord-006664-ykfvbypo	155	17	promote	promote	VB
cord-006664-ykfvbypo	155	18	survival	survival	NN
cord-006664-ykfvbypo	155	19	of	of	IN
cord-006664-ykfvbypo	155	20	the	the	DT
cord-006664-ykfvbypo	155	21	remaining	remain	VBG
cord-006664-ykfvbypo	155	22	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	155	23	.	.	.
cord-006664-ykfvbypo	156	1	The	the	DT
cord-006664-ykfvbypo	156	2	tumour	tumour	NN
cord-006664-ykfvbypo	156	3	suppressor	suppressor	NN
cord-006664-ykfvbypo	156	4	gene	gene	NN
cord-006664-ykfvbypo	156	5	p53	p53	NN
cord-006664-ykfvbypo	156	6	is	be	VBZ
cord-006664-ykfvbypo	156	7	pro	pro	JJ
cord-006664-ykfvbypo	156	8	-	-	JJ
cord-006664-ykfvbypo	156	9	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	156	10	.	.	.
cord-006664-ykfvbypo	157	1	Loss	loss	NN
cord-006664-ykfvbypo	157	2	of	of	IN
cord-006664-ykfvbypo	157	3	p53	p53	NN
cord-006664-ykfvbypo	157	4	function	function	NN
cord-006664-ykfvbypo	157	5	is	be	VBZ
cord-006664-ykfvbypo	157	6	the	the	DT
cord-006664-ykfvbypo	157	7	result	result	NN
cord-006664-ykfvbypo	157	8	of	of	IN
cord-006664-ykfvbypo	157	9	the	the	DT
cord-006664-ykfvbypo	157	10	most	most	RBS
cord-006664-ykfvbypo	157	11	commonly	commonly	RB
cord-006664-ykfvbypo	157	12	mutated	mutate	VBN
cord-006664-ykfvbypo	157	13	gene	gene	NN
cord-006664-ykfvbypo	157	14	in	in	IN
cord-006664-ykfvbypo	157	15	human	human	JJ
cord-006664-ykfvbypo	157	16	malignancies.71	malignancies.71	NNP
cord-006664-ykfvbypo	158	1	It	-PRON-	PRP
cord-006664-ykfvbypo	158	2	acts	act	VBZ
cord-006664-ykfvbypo	158	3	as	as	IN
cord-006664-ykfvbypo	158	4	a	a	DT
cord-006664-ykfvbypo	158	5	cellular	cellular	JJ
cord-006664-ykfvbypo	158	6	sensor	sensor	NN
cord-006664-ykfvbypo	158	7	of	of	IN
cord-006664-ykfvbypo	158	8	DNA	dna	NN
cord-006664-ykfvbypo	158	9	damage	damage	NN
cord-006664-ykfvbypo	158	10	,	,	,
cord-006664-ykfvbypo	158	11	inappropriate	inappropriate	JJ
cord-006664-ykfvbypo	158	12	oncogene	oncogene	NN
cord-006664-ykfvbypo	158	13	activation	activation	NN
cord-006664-ykfvbypo	158	14	,	,	,
cord-006664-ykfvbypo	158	15	hypoxia	hypoxia	NN
cord-006664-ykfvbypo	158	16	and	and	CC
cord-006664-ykfvbypo	158	17	the	the	DT
cord-006664-ykfvbypo	158	18	presence	presence	NN
cord-006664-ykfvbypo	158	19	or	or	CC
cord-006664-ykfvbypo	158	20	absence	absence	NN
cord-006664-ykfvbypo	158	21	of	of	IN
cord-006664-ykfvbypo	158	22	certain	certain	JJ
cord-006664-ykfvbypo	158	23	cytokines	cytokine	NNS
cord-006664-ykfvbypo	158	24	,	,	,
cord-006664-ykfvbypo	158	25	and	and	CC
cord-006664-ykfvbypo	158	26	induces	induce	VBZ
cord-006664-ykfvbypo	158	27	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	158	28	in	in	IN
cord-006664-ykfvbypo	158	29	response	response	NN
cord-006664-ykfvbypo	158	30	to	to	IN
cord-006664-ykfvbypo	158	31	such	such	JJ
cord-006664-ykfvbypo	158	32	stimuli	stimulus	NNS
cord-006664-ykfvbypo	158	33	.	.	.
cord-006664-ykfvbypo	159	1	p53	p53	NN
cord-006664-ykfvbypo	159	2	has	have	VBZ
cord-006664-ykfvbypo	159	3	a	a	DT
cord-006664-ykfvbypo	159	4	role	role	NN
cord-006664-ykfvbypo	159	5	in	in	IN
cord-006664-ykfvbypo	159	6	chaperoning	chaperone	VBG
cord-006664-ykfvbypo	159	7	DNA	dna	NN
cord-006664-ykfvbypo	159	8	,	,	,
cord-006664-ykfvbypo	159	9	inducing	induce	VBG
cord-006664-ykfvbypo	159	10	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	159	11	death	death	NN
cord-006664-ykfvbypo	159	12	when	when	WRB
cord-006664-ykfvbypo	159	13	defects	defect	NNS
cord-006664-ykfvbypo	159	14	emerge	emerge	VBP
cord-006664-ykfvbypo	159	15	.	.	.
cord-006664-ykfvbypo	160	1	737	737	CD
cord-006664-ykfvbypo	160	2	$	$	$
cord-006664-ykfvbypo	161	1	In	in	IN
cord-006664-ykfvbypo	161	2	the	the	DT
cord-006664-ykfvbypo	161	3	cardiovascular	cardiovascular	JJ
cord-006664-ykfvbypo	161	4	system	system	NN
cord-006664-ykfvbypo	161	5	,	,	,
cord-006664-ykfvbypo	161	6	gene	gene	NN
cord-006664-ykfvbypo	161	7	transfer	transfer	NN
cord-006664-ykfvbypo	161	8	-	-	HYPH
cord-006664-ykfvbypo	161	9	induced	induce	VBN
cord-006664-ykfvbypo	161	10	p53	p53	NN
cord-006664-ykfvbypo	161	11	overexpression	overexpression	NN
cord-006664-ykfvbypo	161	12	in	in	IN
cord-006664-ykfvbypo	161	13	normoxic	normoxic	JJ
cord-006664-ykfvbypo	161	14	cultured	culture	VBN
cord-006664-ykfvbypo	161	15	rat	rat	NN
cord-006664-ykfvbypo	161	16	neonatal	neonatal	JJ
cord-006664-ykfvbypo	161	17	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	161	18	can	can	MD
cord-006664-ykfvbypo	161	19	precipitate	precipitate	VB
cord-006664-ykfvbypo	161	20	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	161	21	cell	cell	NN
cord-006664-ykfvbypo	161	22	death	death	NN
cord-006664-ykfvbypo	161	23	.	.	.
cord-006664-ykfvbypo	161	24	'	'	''
cord-006664-ykfvbypo	161	25	;	;	:
cord-006664-ykfvbypo	161	26	Hypoxia	hypoxia	NN
cord-006664-ykfvbypo	161	27	in	in	IN
cord-006664-ykfvbypo	161	28	cultured	cultured	JJ
cord-006664-ykfvbypo	161	29	cardiomyocvtes	cardiomyocvte	NNS
cord-006664-ykfvbypo	161	30	,	,	,
cord-006664-ykfvbypo	161	31	which	which	WDT
cord-006664-ykfvbypo	161	32	induces	induce	VBZ
cord-006664-ykfvbypo	161	33	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	161	34	,	,	,
cord-006664-ykfvbypo	161	35	is	be	VBZ
cord-006664-ykfvbypo	161	36	also	also	RB
cord-006664-ykfvbypo	161	37	associated	associate	VBN
cord-006664-ykfvbypo	161	38	with	with	IN
cord-006664-ykfvbypo	161	39	increased	increase	VBN
cord-006664-ykfvbypo	161	40	p53	p53	NN
cord-006664-ykfvbypo	161	41	expression	expression	NN
cord-006664-ykfvbypo	161	42	.	.	.
cord-006664-ykfvbypo	162	1	°	°	NNP
cord-006664-ykfvbypo	163	1	However	however	RB
cord-006664-ykfvbypo	163	2	,	,	,
cord-006664-ykfvbypo	163	3	in	in	IN
cord-006664-ykfvbypo	163	4	p53	p53	NN
cord-006664-ykfvbypo	163	5	deficient	deficient	JJ
cord-006664-ykfvbypo	163	6	mice	mouse	NNS
cord-006664-ykfvbypo	163	7	,	,	,
cord-006664-ykfvbypo	163	8	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	163	9	may	may	MD
cord-006664-ykfvbypo	163	10	also	also	RB
cord-006664-ykfvbypo	163	11	occur	occur	VB
cord-006664-ykfvbypo	163	12	in	in	IN
cord-006664-ykfvbypo	163	13	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	163	14	by	by	IN
cord-006664-ykfvbypo	163	15	forced	force	VBN
cord-006664-ykfvbypo	163	16	entry	entry	NN
cord-006664-ykfvbypo	163	17	into	into	IN
cord-006664-ykfvbypo	163	18	the	the	DT
cord-006664-ykfvbypo	163	19	S	S	NNP
cord-006664-ykfvbypo	163	20	phase	phase	NN
cord-006664-ykfvbypo	163	21	of	of	IN
cord-006664-ykfvbypo	163	22	the	the	DT
cord-006664-ykfvbypo	163	23	cell	cell	NN
cord-006664-ykfvbypo	163	24	cycle	cycle	NN
cord-006664-ykfvbypo	163	25	.	.	.
cord-006664-ykfvbypo	163	26	'	'	''
cord-006664-ykfvbypo	164	1	7	7	LS
cord-006664-ykfvbypo	164	2	'	'	POS
cord-006664-ykfvbypo	164	3	74'75	74'75	CD
cord-006664-ykfvbypo	164	4	'	'	POS
cord-006664-ykfvbypo	164	5	1	1	CD
cord-006664-ykfvbypo	164	6	°	°	NN
cord-006664-ykfvbypo	164	7	In	in	IN
cord-006664-ykfvbypo	164	8	these	these	DT
cord-006664-ykfvbypo	164	9	p53	p53	NN
cord-006664-ykfvbypo	164	10	deficient	deficient	JJ
cord-006664-ykfvbypo	164	11	mice	mouse	NNS
cord-006664-ykfvbypo	164	12	,	,	,
cord-006664-ykfvbypo	164	13	ligation	ligation	NN
cord-006664-ykfvbypo	164	14	of	of	IN
cord-006664-ykfvbypo	164	15	the	the	DT
cord-006664-ykfvbypo	164	16	left	left	JJ
cord-006664-ykfvbypo	164	17	coronary	coronary	JJ
cord-006664-ykfvbypo	164	18	artery	artery	NN
cord-006664-ykfvbypo	164	19	does	do	VBZ
cord-006664-ykfvbypo	164	20	not	not	RB
cord-006664-ykfvbypo	164	21	alter	alter	VB
cord-006664-ykfvbypo	164	22	the	the	DT
cord-006664-ykfvbypo	164	23	degree	degree	NN
cord-006664-ykfvbypo	164	24	of	of	IN
cord-006664-ykfvbypo	164	25	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	164	26	in	in	IN
cord-006664-ykfvbypo	164	27	hypoxic	hypoxic	JJ
cord-006664-ykfvbypo	164	28	areas	area	NNS
cord-006664-ykfvbypo	164	29	when	when	WRB
cord-006664-ykfvbypo	164	30	compared	compare	VBN
cord-006664-ykfvbypo	164	31	with	with	IN
cord-006664-ykfvbypo	164	32	wild	wild	JJ
cord-006664-ykfvbypo	164	33	type	type	NN
cord-006664-ykfvbypo	164	34	mice	mouse	NNS
cord-006664-ykfvbypo	164	35	.	.	.
cord-006664-ykfvbypo	165	1	7	7	CD
cord-006664-ykfvbypo	165	2	°	°	NN
cord-006664-ykfvbypo	165	3	K	K	NNP
cord-006664-ykfvbypo	165	4	irshenbaum	irshenbaum	NNP
cord-006664-ykfvbypo	165	5	and	and	CC
cord-006664-ykfvbypo	165	6	de	de	NNP
cord-006664-ykfvbypo	165	7	r%,Ioissac	r%,Ioissac	NNP
cord-006664-ykfvbypo	165	8	'	'	''
cord-006664-ykfvbypo	165	9	'	'	''
cord-006664-ykfvbypo	165	10	and	and	CC
cord-006664-ykfvbypo	165	11	Kirshenbaum	Kirshenbaum	NNP
cord-006664-ykfvbypo	165	12	78	78	CD
cord-006664-ykfvbypo	165	13	have	have	VBP
cord-006664-ykfvbypo	165	14	shown	show	VBN
cord-006664-ykfvbypo	165	15	that	that	DT
cord-006664-ykfvbypo	165	16	p53	p53	NN
cord-006664-ykfvbypo	165	17	interacts	interact	VBZ
cord-006664-ykfvbypo	165	18	dynamically	dynamically	RB
cord-006664-ykfvbypo	165	19	with	with	IN
cord-006664-ykfvbypo	165	20	other	other	JJ
cord-006664-ykfvbypo	165	21	proto	proto	JJ
cord-006664-ykfvbypo	165	22	-	-	HYPH
cord-006664-ykfvbypo	165	23	oncogenes	oncogene	NNS
cord-006664-ykfvbypo	165	24	involved	involve	VBN
cord-006664-ykfvbypo	165	25	in	in	IN
cord-006664-ykfvbypo	165	26	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	165	27	regulation	regulation	NN
cord-006664-ykfvbypo	165	28	.	.	.
cord-006664-ykfvbypo	166	1	p53	p53	NN
cord-006664-ykfvbypo	166	2	expression	expression	NN
cord-006664-ykfvbypo	166	3	causes	cause	VBZ
cord-006664-ykfvbypo	166	4	an	an	DT
cord-006664-ykfvbypo	166	5	upregulation	upregulation	NN
cord-006664-ykfvbypo	166	6	of	of	IN
cord-006664-ykfvbypo	166	7	pro	pro	JJ
cord-006664-ykfvbypo	166	8	-	-	JJ
cord-006664-ykfvbypo	166	9	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	166	10	Bax	Bax	NNP
cord-006664-ykfvbypo	166	11	,	,	,
cord-006664-ykfvbypo	166	12	but	but	CC
cord-006664-ykfvbypo	166	13	this	this	DT
cord-006664-ykfvbypo	166	14	effect	effect	NN
cord-006664-ykfvbypo	166	15	and	and	CC
cord-006664-ykfvbypo	166	16	its	-PRON-	PRP$
cord-006664-ykfvbypo	166	17	own	own	JJ
cord-006664-ykfvbypo	166	18	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	166	19	potency	potency	NN
cord-006664-ykfvbypo	166	20	are	be	VBP
cord-006664-ykfvbypo	166	21	downregulated	downregulate	VBN
cord-006664-ykfvbypo	166	22	by	by	IN
cord-006664-ykfvbypo	166	23	bcl-2	bcl-2	VBG
cord-006664-ykfvbypo	166	24	expression	expression	NN
cord-006664-ykfvbypo	166	25	.	.	.
cord-006664-ykfvbypo	167	1	77	77	CD
cord-006664-ykfvbypo	167	2	'	'	CD
cord-006664-ykfvbypo	167	3	78	78	CD
cord-006664-ykfvbypo	167	4	Nitric	nitric	NN
cord-006664-ykfvbypo	167	5	oxide	oxide	NN
cord-006664-ykfvbypo	167	6	Nitric	nitric	NN
cord-006664-ykfvbypo	167	7	oxide	oxide	NN
cord-006664-ykfvbypo	167	8	(	(	-LRB-
cord-006664-ykfvbypo	167	9	NO	no	UH
cord-006664-ykfvbypo	167	10	)	)	-RRB-
cord-006664-ykfvbypo	167	11	is	be	VBZ
cord-006664-ykfvbypo	167	12	involved	involve	VBN
cord-006664-ykfvbypo	167	13	in	in	IN
cord-006664-ykfvbypo	167	14	vessel	vessel	NN
cord-006664-ykfvbypo	167	15	relaxation	relaxation	NN
cord-006664-ykfvbypo	167	16	,	,	,
cord-006664-ykfvbypo	167	17	inhibition	inhibition	NN
cord-006664-ykfvbypo	167	18	of	of	IN
cord-006664-ykfvbypo	167	19	smooth	smooth	JJ
cord-006664-ykfvbypo	167	20	muscle	muscle	NN
cord-006664-ykfvbypo	167	21	and	and	CC
cord-006664-ykfvbypo	167	22	endothelial	endothelial	JJ
cord-006664-ykfvbypo	167	23	cell	cell	NN
cord-006664-ykfvbypo	167	24	proliferation	proliferation	NN
cord-006664-ykfvbypo	167	25	,	,	,
cord-006664-ykfvbypo	167	26	and	and	CC
cord-006664-ykfvbypo	167	27	reduction	reduction	NN
cord-006664-ykfvbypo	167	28	of	of	IN
cord-006664-ykfvbypo	167	29	platelet	platelet	NN
cord-006664-ykfvbypo	167	30	adhesion	adhesion	NN
cord-006664-ykfvbypo	167	31	.	.	.
cord-006664-ykfvbypo	168	1	79	79	CD
cord-006664-ykfvbypo	168	2	'	'	POS
cord-006664-ykfvbypo	168	3	8	8	CD
cord-006664-ykfvbypo	168	4	°	°	NN
cord-006664-ykfvbypo	168	5	In	in	IN
cord-006664-ykfvbypo	168	6	the	the	DT
cord-006664-ykfvbypo	168	7	myocardium	myocardium	NN
cord-006664-ykfvbypo	168	8	,	,	,
cord-006664-ykfvbypo	168	9	recent	recent	JJ
cord-006664-ykfvbypo	168	10	work	work	NN
cord-006664-ykfvbypo	168	11	has	have	VBZ
cord-006664-ykfvbypo	168	12	shown	show	VBN
cord-006664-ykfvbypo	168	13	that	that	IN
cord-006664-ykfvbypo	168	14	constitutively	constitutively	RB
cord-006664-ykfvbypo	168	15	expressed	express	VBN
cord-006664-ykfvbypo	168	16	NO	no	DT
cord-006664-ykfvbypo	168	17	synthase	synthase	NN
cord-006664-ykfvbypo	168	18	(	(	-LRB-
cord-006664-ykfvbypo	168	19	cNOS	cNOS	NNP
cord-006664-ykfvbypo	168	20	)	)	-RRB-
cord-006664-ykfvbypo	168	21	,	,	,
cord-006664-ykfvbypo	168	22	inducible	inducible	JJ
cord-006664-ykfvbypo	168	23	NO	no	DT
cord-006664-ykfvbypo	168	24	synthase	synthase	NN
cord-006664-ykfvbypo	168	25	(	(	-LRB-
cord-006664-ykfvbypo	168	26	iNOS	inos	NN
cord-006664-ykfvbypo	168	27	)	)	-RRB-
cord-006664-ykfvbypo	168	28	and	and	CC
cord-006664-ykfvbypo	168	29	endothelial	endothelial	JJ
cord-006664-ykfvbypo	168	30	NO	no	DT
cord-006664-ykfvbypo	168	31	synthase	synthase	NN
cord-006664-ykfvbypo	168	32	(	(	-LRB-
cord-006664-ykfvbypo	168	33	eNOS	enos	JJ
cord-006664-ykfvbypo	168	34	)	)	-RRB-
cord-006664-ykfvbypo	168	35	have	have	VBP
cord-006664-ykfvbypo	168	36	functional	functional	JJ
cord-006664-ykfvbypo	168	37	autocrine	autocrine	NN
cord-006664-ykfvbypo	168	38	and	and	CC
cord-006664-ykfvbypo	168	39	paracrine	paracrine	JJ
cord-006664-ykfvbypo	168	40	effects	effect	NNS
cord-006664-ykfvbypo	168	41	similar	similar	JJ
cord-006664-ykfvbypo	168	42	to	to	IN
cord-006664-ykfvbypo	168	43	their	-PRON-	PRP$
cord-006664-ykfvbypo	168	44	effects	effect	NNS
cord-006664-ykfvbypo	168	45	on	on	IN
cord-006664-ykfvbypo	169	1	vascular	vascular	JJ
cord-006664-ykfvbypo	169	2	cells.$	cells.$	NNP
cord-006664-ykfvbypo	169	3	`	`	''
cord-006664-ykfvbypo	169	4	NO	no	DT
cord-006664-ykfvbypo	169	5	release	release	NN
cord-006664-ykfvbypo	169	6	precipitates	precipitate	VBZ
cord-006664-ykfvbypo	169	7	myocardial	myocardial	JJ
cord-006664-ykfvbypo	169	8	depression	depression	NN
cord-006664-ykfvbypo	169	9	in	in	IN
cord-006664-ykfvbypo	169	10	response	response	NN
cord-006664-ykfvbypo	169	11	to	to	IN
cord-006664-ykfvbypo	169	12	systemic	systemic	JJ
cord-006664-ykfvbypo	169	13	disturbance	disturbance	NN
cord-006664-ykfvbypo	169	14	and	and	CC
cord-006664-ykfvbypo	169	15	part	part	NN
cord-006664-ykfvbypo	169	16	of	of	IN
cord-006664-ykfvbypo	169	17	this	this	DT
cord-006664-ykfvbypo	169	18	dysfunction	dysfunction	NN
cord-006664-ykfvbypo	169	19	is	be	VBZ
cord-006664-ykfvbypo	169	20	mediated	mediate	VBN
cord-006664-ykfvbypo	169	21	by	by	IN
cord-006664-ykfvbypo	169	22	NOinduced	NOinduced	NNP
cord-006664-ykfvbypo	169	23	cardiomyocyte	cardiomyocyte	NNP
cord-006664-ykfvbypo	169	24	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	169	25	.	.	.
cord-006664-ykfvbypo	169	26	98	98	CD
cord-006664-ykfvbypo	170	1	In	in	IN
cord-006664-ykfvbypo	170	2	a	a	DT
cord-006664-ykfvbypo	170	3	rat	rat	NN
cord-006664-ykfvbypo	170	4	model	model	NN
cord-006664-ykfvbypo	170	5	of	of	IN
cord-006664-ykfvbypo	170	6	heterotopic	heterotopic	NNP
cord-006664-ykfvbypo	170	7	cardiac	cardiac	JJ
cord-006664-ykfvbypo	170	8	transplantation	transplantation	NN
cord-006664-ykfvbypo	170	9	,	,	,
cord-006664-ykfvbypo	170	10	it	-PRON-	PRP
cord-006664-ykfvbypo	170	11	was	be	VBD
cord-006664-ykfvbypo	170	12	shown	show	VBN
cord-006664-ykfvbypo	170	13	that	that	DT
cord-006664-ykfvbypo	170	14	rejection	rejection	NN
cord-006664-ykfvbypo	170	15	was	be	VBD
cord-006664-ykfvbypo	170	16	associated	associate	VBN
cord-006664-ykfvbypo	170	17	with	with	IN
cord-006664-ykfvbypo	170	18	significant	significant	JJ
cord-006664-ykfvbypo	170	19	induction	induction	NN
cord-006664-ykfvbypo	170	20	of	of	IN
cord-006664-ykfvbypo	170	21	the	the	DT
cord-006664-ykfvbypo	170	22	mRNA	mrna	NN
cord-006664-ykfvbypo	170	23	,	,	,
cord-006664-ykfvbypo	170	24	protein	protein	NN
cord-006664-ykfvbypo	170	25	and	and	CC
cord-006664-ykfvbypo	170	26	enzyme	enzyme	NN
cord-006664-ykfvbypo	170	27	activity	activity	NN
cord-006664-ykfvbypo	170	28	of	of	IN
cord-006664-ykfvbypo	170	29	iNOS	inos	NN
cord-006664-ykfvbypo	170	30	.	.	.
cord-006664-ykfvbypo	171	1	82	82	CD
cord-006664-ykfvbypo	171	2	'	'	CD
cord-006664-ykfvbypo	171	3	83	83	CD
cord-006664-ykfvbypo	172	1	This	this	DT
cord-006664-ykfvbypo	172	2	was	be	VBD
cord-006664-ykfvbypo	172	3	detectable	detectable	JJ
cord-006664-ykfvbypo	172	4	in	in	IN
cord-006664-ykfvbypo	172	5	endothelial	endothelial	JJ
cord-006664-ykfvbypo	172	6	cells	cell	NNS
cord-006664-ykfvbypo	172	7	,	,	,
cord-006664-ykfvbypo	172	8	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	172	9	and	and	CC
cord-006664-ykfvbypo	172	10	infiltrating	infiltrate	VBG
cord-006664-ykfvbypo	172	11	monocytes.99	monocytes.99	NNP
cord-006664-ykfvbypo	173	1	Further	further	JJ
cord-006664-ykfvbypo	173	2	work	work	NN
cord-006664-ykfvbypo	173	3	expanded	expand	VBD
cord-006664-ykfvbypo	173	4	the	the	DT
cord-006664-ykfvbypo	173	5	understanding	understanding	NN
cord-006664-ykfvbypo	173	6	of	of	IN
cord-006664-ykfvbypo	173	7	the	the	DT
cord-006664-ykfvbypo	173	8	role	role	NN
cord-006664-ykfvbypo	173	9	of	of	IN
cord-006664-ykfvbypo	173	10	NO	no	DT
cord-006664-ykfvbypo	173	11	in	in	IN
cord-006664-ykfvbypo	173	12	this	this	DT
cord-006664-ykfvbypo	173	13	context	context	NN
cord-006664-ykfvbypo	173	14	by	by	IN
cord-006664-ykfvbypo	173	15	demonstrating	demonstrate	VBG
cord-006664-ykfvbypo	173	16	that	that	DT
cord-006664-ykfvbypo	173	17	cytokine	cytokine	NN
cord-006664-ykfvbypo	173	18	induction	induction	NN
cord-006664-ykfvbypo	173	19	of	of	IN
cord-006664-ykfvbypo	173	20	iNOS	inos	NN
cord-006664-ykfvbypo	173	21	was	be	VBD
cord-006664-ykfvbypo	173	22	associated	associate	VBN
cord-006664-ykfvbypo	173	23	with	with	IN
cord-006664-ykfvbypo	173	24	NO	no	RB
cord-006664-ykfvbypo	173	25	-	-	HYPH
cord-006664-ykfvbypo	173	26	mediated	mediate	VBN
cord-006664-ykfvbypo	173	27	death	death	NN
cord-006664-ykfvbypo	173	28	of	of	IN
cord-006664-ykfvbypo	173	29	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	173	30	in	in	IN
cord-006664-ykfvbypo	173	31	vitro	vitro	FW
cord-006664-ykfvbypo	173	32	.	.	.
cord-006664-ykfvbypo	173	33	"	"	''
cord-006664-ykfvbypo	174	1	Szabolcs	Szabolcs	NNP
cord-006664-ykfvbypo	174	2	et	et	FW
cord-006664-ykfvbypo	174	3	al	al	NNP
cord-006664-ykfvbypo	174	4	subsequently	subsequently	RB
cord-006664-ykfvbypo	174	5	confirmed	confirm	VBD
cord-006664-ykfvbypo	174	6	that	that	IN
cord-006664-ykfvbypo	174	7	the	the	DT
cord-006664-ykfvbypo	174	8	mechanism	mechanism	NN
cord-006664-ykfvbypo	174	9	whereby	whereby	WRB
cord-006664-ykfvbypo	174	10	NO	no	RB
cord-006664-ykfvbypo	174	11	-	-	HYPH
cord-006664-ykfvbypo	174	12	induced	induce	VBN
cord-006664-ykfvbypo	174	13	cardiomyocyte	cardiomyocyte	NNP
cord-006664-ykfvbypo	174	14	death	death	NN
cord-006664-ykfvbypo	174	15	in	in	IN
cord-006664-ykfvbypo	174	16	vivo	vivo	NNP
cord-006664-ykfvbypo	174	17	was	be	VBD
cord-006664-ykfvbypo	174	18	indeed	indeed	RB
cord-006664-ykfvbypo	174	19	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	174	20	,	,	,
cord-006664-ykfvbypo	174	21	thereby	thereby	RB
cord-006664-ykfvbypo	174	22	demonstrating	demonstrate	VBG
cord-006664-ykfvbypo	174	23	directly	directly	RB
cord-006664-ykfvbypo	174	24	the	the	DT
cord-006664-ykfvbypo	174	25	link	link	NN
cord-006664-ykfvbypo	174	26	between	between	IN
cord-006664-ykfvbypo	174	27	NO	no	NN
cord-006664-ykfvbypo	174	28	and	and	CC
cord-006664-ykfvbypo	174	29	cardiac	cardiac	JJ
cord-006664-ykfvbypo	174	30	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	174	31	.	.	.
cord-006664-ykfvbypo	175	1	`	`	``
cord-006664-ykfvbypo	175	2	°	°	NNP
cord-006664-ykfvbypo	175	3	°	°	NNP
cord-006664-ykfvbypo	175	4	I	I	NNP
cord-006664-ykfvbypo	175	5	n	n	NNP
cord-006664-ykfvbypo	175	6	vivo	vivo	NN
cord-006664-ykfvbypo	175	7	gene	gene	NN
cord-006664-ykfvbypo	175	8	transfer	transfer	NN
cord-006664-ykfvbypo	175	9	studies	study	NNS
cord-006664-ykfvbypo	175	10	of	of	IN
cord-006664-ykfvbypo	175	11	endothelial	endothelial	JJ
cord-006664-ykfvbypo	175	12	cell	cell	NN
cord-006664-ykfvbypo	176	1	NO	no	DT
cord-006664-ykfvbypo	176	2	synthase	synthase	NN
cord-006664-ykfvbypo	176	3	(	(	-LRB-
cord-006664-ykfvbypo	176	4	ecNOS	ecnos	NN
cord-006664-ykfvbypo	176	5	)	)	-RRB-
cord-006664-ykfvbypo	176	6	activity	activity	NN
cord-006664-ykfvbypo	176	7	to	to	IN
cord-006664-ykfvbypo	176	8	the	the	DT
cord-006664-ykfvbypo	176	9	myocardium	myocardium	NN
cord-006664-ykfvbypo	176	10	resulted	result	VBD
cord-006664-ykfvbypo	176	11	in	in	IN
cord-006664-ykfvbypo	176	12	cardiomyocyte	cardiomyocyte	NNP
cord-006664-ykfvbypo	176	13	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	176	14	.	.	.
cord-006664-ykfvbypo	177	1	85	85	CD
cord-006664-ykfvbypo	178	1	The	the	DT
cord-006664-ykfvbypo	178	2	suggestion	suggestion	NN
cord-006664-ykfvbypo	178	3	from	from	IN
cord-006664-ykfvbypo	178	4	this	this	DT
cord-006664-ykfvbypo	178	5	study	study	NN
cord-006664-ykfvbypo	178	6	was	be	VBD
cord-006664-ykfvbypo	178	7	that	that	IN
cord-006664-ykfvbypo	178	8	the	the	DT
cord-006664-ykfvbypo	178	9	inflammation	inflammation	NN
cord-006664-ykfvbypo	178	10	and	and	CC
cord-006664-ykfvbypo	178	11	cvtokine	cvtokine	NN
cord-006664-ykfvbypo	178	12	release	release	NN
cord-006664-ykfvbypo	178	13	associated	associate	VBN
cord-006664-ykfvbypo	178	14	with	with	IN
cord-006664-ykfvbypo	178	15	myocardial	myocardial	JJ
cord-006664-ykfvbypo	178	16	infarction	infarction	NN
cord-006664-ykfvbypo	178	17	,	,	,
cord-006664-ykfvbypo	178	18	myocarditis	myocarditis	NN
cord-006664-ykfvbypo	178	19	and	and	CC
cord-006664-ykfvbypo	178	20	.	.	.
cord-006664-ykfvbypo	179	1	cardiomyopathies	cardiomyopathies	NNP
cord-006664-ykfvbypo	179	2	may	may	MD
cord-006664-ykfvbypo	179	3	result	result	VB
cord-006664-ykfvbypo	179	4	in	in	IN
cord-006664-ykfvbypo	179	5	similar	similar	JJ
cord-006664-ykfvbypo	179	6	pro	pro	JJ
cord-006664-ykfvbypo	179	7	-	-	JJ
cord-006664-ykfvbypo	179	8	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	179	9	effects	effect	NNS
cord-006664-ykfvbypo	179	10	on	on	IN
cord-006664-ykfvbypo	179	11	cazdiomyocytes	cazdiomyocyte	NNS
cord-006664-ykfvbypo	179	12	via	via	IN
cord-006664-ykfvbypo	179	13	NO	no	RB
cord-006664-ykfvbypo	179	14	-	-	HYPH
cord-006664-ykfvbypo	179	15	dependent	dependent	JJ
cord-006664-ykfvbypo	179	16	mechanisms	mechanism	NNS
cord-006664-ykfvbypo	179	17	.	.	.
cord-006664-ykfvbypo	180	1	In	in	IN
cord-006664-ykfvbypo	180	2	the	the	DT
cord-006664-ykfvbypo	180	3	myocardium	myocardium	NN
cord-006664-ykfvbypo	180	4	,	,	,
cord-006664-ykfvbypo	180	5	NO	NO	NNP
cord-006664-ykfvbypo	180	6	activates	activate	VBZ
cord-006664-ykfvbypo	180	7	cGMP	cgmp	JJ
cord-006664-ykfvbypo	180	8	-	-	HYPH
cord-006664-ykfvbypo	180	9	dependent	dependent	JJ
cord-006664-ykfvbypo	180	10	protein	protein	NN
cord-006664-ykfvbypo	180	11	kinases	kinase	NNS
cord-006664-ykfvbypo	180	12	and	and	CC
cord-006664-ykfvbypo	180	13	cGMP	cgmp	JJ
cord-006664-ykfvbypo	180	14	-	-	HYPH
cord-006664-ykfvbypo	180	15	modulated	modulate	VBN
cord-006664-ykfvbypo	180	16	phosphodiesterases	phosphodiesterase	NNS
cord-006664-ykfvbypo	180	17	,	,	,
cord-006664-ykfvbypo	180	18	thus	thus	RB
cord-006664-ykfvbypo	180	19	regulating	regulate	VBG
cord-006664-ykfvbypo	180	20	calcium	calcium	NN
cord-006664-ykfvbypo	180	21	current	current	JJ
cord-006664-ykfvbypo	180	22	and	and	CC
cord-006664-ykfvbypo	180	23	contraction	contraction	NN
cord-006664-ykfvbypo	180	24	.	.	.
cord-006664-ykfvbypo	181	1	103	103	CD
cord-006664-ykfvbypo	182	1	In	in	IN
cord-006664-ykfvbypo	182	2	the	the	DT
cord-006664-ykfvbypo	182	3	course	course	NN
cord-006664-ykfvbypo	182	4	of	of	IN
cord-006664-ykfvbypo	182	5	oxidative	oxidative	JJ
cord-006664-ykfvbypo	182	6	injury	injury	NN
cord-006664-ykfvbypo	182	7	(	(	-LRB-
cord-006664-ykfvbypo	182	8	such	such	JJ
cord-006664-ykfvbypo	182	9	as	as	IN
cord-006664-ykfvbypo	182	10	IR	IR	NNP
cord-006664-ykfvbypo	182	11	)	)	-RRB-
cord-006664-ykfvbypo	182	12	,	,	,
cord-006664-ykfvbypo	182	13	the	the	DT
cord-006664-ykfvbypo	182	14	simultaneous	simultaneous	JJ
cord-006664-ykfvbypo	182	15	production	production	NN
cord-006664-ykfvbypo	182	16	of	of	IN
cord-006664-ykfvbypo	182	17	NO	no	NN
cord-006664-ykfvbypo	182	18	and	and	CC
cord-006664-ykfvbypo	182	19	superoxide	superoxide	NN
cord-006664-ykfvbypo	182	20	leads	lead	VBZ
cord-006664-ykfvbypo	182	21	to	to	IN
cord-006664-ykfvbypo	182	22	the	the	DT
cord-006664-ykfvbypo	182	23	formation	formation	NN
cord-006664-ykfvbypo	182	24	of	of	IN
cord-006664-ykfvbypo	182	25	peroxynitrite	peroxynitrite	NN
cord-006664-ykfvbypo	182	26	.	.	.
cord-006664-ykfvbypo	183	1	It	-PRON-	PRP
cord-006664-ykfvbypo	183	2	now	now	RB
cord-006664-ykfvbypo	183	3	appears	appear	VBZ
cord-006664-ykfvbypo	183	4	that	that	IN
cord-006664-ykfvbypo	183	5	peroxynitrite	peroxynitrite	NN
cord-006664-ykfvbypo	183	6	is	be	VBZ
cord-006664-ykfvbypo	183	7	a	a	DT
cord-006664-ykfvbypo	183	8	significant	significant	JJ
cord-006664-ykfvbypo	183	9	mediator	mediator	NN
cord-006664-ykfvbypo	183	10	of	of	IN
cord-006664-ykfvbypo	183	11	injury	injury	NN
cord-006664-ykfvbypo	183	12	previously	previously	RB
cord-006664-ykfvbypo	183	13	attributed	attribute	VBN
cord-006664-ykfvbypo	183	14	solely	solely	RB
cord-006664-ykfvbypo	183	15	to	to	IN
cord-006664-ykfvbypo	183	16	NO	no	NN
cord-006664-ykfvbypo	183	17	or	or	CC
cord-006664-ykfvbypo	183	18	superoxide	superoxide	NN
cord-006664-ykfvbypo	183	19	.	.	.
cord-006664-ykfvbypo	184	1	88	88	CD
cord-006664-ykfvbypo	184	2	Peroxynitrite	peroxynitrite	JJ
cord-006664-ykfvbypo	184	3	production	production	NN
cord-006664-ykfvbypo	184	4	results	result	NNS
cord-006664-ykfvbypo	184	5	in	in	IN
cord-006664-ykfvbypo	184	6	single	single	JJ
cord-006664-ykfvbypo	184	7	strand	strand	NN
cord-006664-ykfvbypo	184	8	DNA	dna	NN
cord-006664-ykfvbypo	184	9	breaks	break	NNS
cord-006664-ykfvbypo	184	10	,	,	,
cord-006664-ykfvbypo	184	11	with	with	IN
cord-006664-ykfvbypo	184	12	consequent	consequent	JJ
cord-006664-ykfvbypo	184	13	activation	activation	NN
cord-006664-ykfvbypo	184	14	of	of	IN
cord-006664-ykfvbypo	184	15	poly	poly	JJ
cord-006664-ykfvbypo	184	16	ADP	ADP	NNP
cord-006664-ykfvbypo	184	17	-	-	HYPH
cord-006664-ykfvbypo	184	18	ribose	ribose	NN
cord-006664-ykfvbypo	184	19	synthetase	synthetase	NN
cord-006664-ykfvbypo	184	20	(	(	-LRB-
cord-006664-ykfvbypo	184	21	PARS	PARS	NNP
cord-006664-ykfvbypo	184	22	)	)	-RRB-
cord-006664-ykfvbypo	184	23	which	which	WDT
cord-006664-ykfvbypo	184	24	is	be	VBZ
cord-006664-ykfvbypo	184	25	cytotoxic	cytotoxic	JJ
cord-006664-ykfvbypo	184	26	.	.	.
cord-006664-ykfvbypo	185	1	105	105	CD
cord-006664-ykfvbypo	186	1	This	this	DT
cord-006664-ykfvbypo	186	2	mechanism	mechanism	NN
cord-006664-ykfvbypo	186	3	has	have	VBZ
cord-006664-ykfvbypo	186	4	now	now	RB
cord-006664-ykfvbypo	186	5	been	be	VBN
cord-006664-ykfvbypo	186	6	shown	show	VBN
cord-006664-ykfvbypo	186	7	to	to	TO
cord-006664-ykfvbypo	186	8	cause	cause	VB
cord-006664-ykfvbypo	186	9	endothelial	endothelial	JJ
cord-006664-ykfvbypo	186	10	cell	cell	NN
cord-006664-ykfvbypo	186	11	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	186	12	in	in	IN
cord-006664-ykfvbypo	186	13	vitro	vitro	FW
cord-006664-ykfvbypo	186	14	.	.	.
cord-006664-ykfvbypo	186	15	'	'	''
cord-006664-ykfvbypo	187	1	05	05	CD
cord-006664-ykfvbypo	188	1	NO	no	DT
cord-006664-ykfvbypo	188	2	appears	appear	VBZ
cord-006664-ykfvbypo	188	3	to	to	TO
cord-006664-ykfvbypo	188	4	play	play	VB
cord-006664-ykfvbypo	188	5	a	a	DT
cord-006664-ykfvbypo	188	6	major	major	JJ
cord-006664-ykfvbypo	188	7	role	role	NN
cord-006664-ykfvbypo	188	8	in	in	IN
cord-006664-ykfvbypo	188	9	vessel	vessel	NN
cord-006664-ykfvbypo	188	10	wall	wall	NN
cord-006664-ykfvbypo	188	11	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	188	12	by	by	IN
cord-006664-ykfvbypo	188	13	inducing	induce	VBG
cord-006664-ykfvbypo	188	14	programmed	programmed	JJ
cord-006664-ykfvbypo	188	15	cell	cell	NN
cord-006664-ykfvbypo	188	16	death	death	NN
cord-006664-ykfvbypo	188	17	in	in	IN
cord-006664-ykfvbypo	188	18	smooth	smooth	JJ
cord-006664-ykfvbypo	188	19	muscle	muscle	NN
cord-006664-ykfvbypo	188	20	cells	cell	NNS
cord-006664-ykfvbypo	188	21	and	and	CC
cord-006664-ykfvbypo	188	22	infiltrating	infiltrate	VBG
cord-006664-ykfvbypo	188	23	monocytes	monocyte	NNS
cord-006664-ykfvbypo	188	24	.	.	.
cord-006664-ykfvbypo	189	1	$	$	$
cord-006664-ykfvbypo	189	2	'	'	``
cord-006664-ykfvbypo	189	3	NO	no	DT
cord-006664-ykfvbypo	189	4	activity	activity	NN
cord-006664-ykfvbypo	189	5	is	be	VBZ
cord-006664-ykfvbypo	189	6	reduced	reduce	VBN
cord-006664-ykfvbypo	189	7	in	in	IN
cord-006664-ykfvbypo	189	8	the	the	DT
cord-006664-ykfvbypo	189	9	vessel	vessel	NN
cord-006664-ykfvbypo	189	10	wall	wall	NN
cord-006664-ykfvbypo	189	11	in	in	IN
cord-006664-ykfvbypo	189	12	hypercholesterolaemia	hypercholesterolaemia	NN
cord-006664-ykfvbypo	189	13	suggesting	suggest	VBG
cord-006664-ykfvbypo	189	14	a	a	DT
cord-006664-ykfvbypo	189	15	potential	potential	JJ
cord-006664-ykfvbypo	189	16	mechanism	mechanism	NN
cord-006664-ykfvbypo	189	17	whereby	whereby	WRB
cord-006664-ykfvbypo	189	18	diminished	diminish	VBD
cord-006664-ykfvbypo	189	19	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	189	20	control	control	NN
cord-006664-ykfvbypo	189	21	of	of	IN
cord-006664-ykfvbypo	189	22	cellular	cellular	JJ
cord-006664-ykfvbypo	189	23	homeostasis	homeostasis	NN
cord-006664-ykfvbypo	189	24	allows	allow	VBZ
cord-006664-ykfvbypo	189	25	progression	progression	NN
cord-006664-ykfvbypo	189	26	of	of	IN
cord-006664-ykfvbypo	189	27	atherosclerosis	atherosclerosis	NN
cord-006664-ykfvbypo	189	28	.	.	.
cord-006664-ykfvbypo	190	1	NF	NF	NNP
cord-006664-ykfvbypo	190	2	-	-	HYPH
cord-006664-ykfvbypo	190	3	kb	kb	NNP
cord-006664-ykfvbypo	190	4	has	have	VBZ
cord-006664-ykfvbypo	190	5	a	a	DT
cord-006664-ykfvbypo	190	6	potent	potent	JJ
cord-006664-ykfvbypo	190	7	anti	anti	JJ
cord-006664-ykfvbypo	190	8	-	-	JJ
cord-006664-ykfvbypo	190	9	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	190	10	role	role	NN
cord-006664-ykfvbypo	190	11	.	.	.
cord-006664-ykfvbypo	191	1	In	in	IN
cord-006664-ykfvbypo	191	2	the	the	DT
cord-006664-ykfvbypo	191	3	vascular	vascular	JJ
cord-006664-ykfvbypo	191	4	endothelium	endothelium	NN
cord-006664-ykfvbypo	191	5	,	,	,
cord-006664-ykfvbypo	191	6	it	-PRON-	PRP
cord-006664-ykfvbypo	191	7	is	be	VBZ
cord-006664-ykfvbypo	191	8	expressed	express	VBN
cord-006664-ykfvbypo	191	9	constitutively	constitutively	RB
cord-006664-ykfvbypo	191	10	and	and	CC
cord-006664-ykfvbypo	191	11	can	can	MD
cord-006664-ykfvbypo	191	12	be	be	VB
cord-006664-ykfvbypo	191	13	upregulated	upregulate	VBN
cord-006664-ykfvbypo	191	14	by	by	IN
cord-006664-ykfvbypo	191	15	stimuli	stimulus	NNS
cord-006664-ykfvbypo	191	16	such	such	JJ
cord-006664-ykfvbypo	191	17	as	as	IN
cord-006664-ykfvbypo	191	18	IL-6	IL-6	NNP
cord-006664-ykfvbypo	191	19	,	,	,
cord-006664-ykfvbypo	191	20	thrombin	thrombin	NN
cord-006664-ykfvbypo	191	21	,	,	,
cord-006664-ykfvbypo	191	22	platelet	platelet	NN
cord-006664-ykfvbypo	191	23	-	-	HYPH
cord-006664-ykfvbypo	191	24	derived	derive	VBN
cord-006664-ykfvbypo	191	25	growth	growth	NN
cord-006664-ykfvbypo	191	26	factor	factor	NN
cord-006664-ykfvbypo	191	27	(	(	-LRB-
cord-006664-ykfvbypo	191	28	PDGF	PDGF	NNP
cord-006664-ykfvbypo	191	29	)	)	-RRB-
cord-006664-ykfvbypo	191	30	and	and	CC
cord-006664-ykfvbypo	191	31	basic	basic	JJ
cord-006664-ykfvbypo	191	32	fibroblast	fibroblast	NN
cord-006664-ykfvbypo	191	33	growth	growth	NN
cord-006664-ykfvbypo	191	34	factor	factor	NN
cord-006664-ykfvbypo	191	35	.	.	.
cord-006664-ykfvbypo	192	1	88	88	CD
cord-006664-ykfvbypo	192	2	,	,	,
cord-006664-ykfvbypo	192	3	9	9	CD
cord-006664-ykfvbypo	193	1	In	in	IN
cord-006664-ykfvbypo	193	2	addition	addition	NN
cord-006664-ykfvbypo	193	3	,	,	,
cord-006664-ykfvbypo	193	4	it	-PRON-	PRP
cord-006664-ykfvbypo	193	5	is	be	VBZ
cord-006664-ykfvbypo	193	6	essential	essential	JJ
cord-006664-ykfvbypo	193	7	for	for	IN
cord-006664-ykfvbypo	193	8	in	in	FW
cord-006664-ykfvbypo	193	9	vitro	vitro	FW
cord-006664-ykfvbypo	193	10	proliferation	proliferation	NN
cord-006664-ykfvbypo	193	11	of	of	IN
cord-006664-ykfvbypo	193	12	vascular	vascular	JJ
cord-006664-ykfvbypo	193	13	.	.	.
cord-006664-ykfvbypo	194	1	smooth	smooth	JJ
cord-006664-ykfvbypo	194	2	muscle	muscle	NN
cord-006664-ykfvbypo	194	3	cells	cell	NNS
cord-006664-ykfvbypo	194	4	.	.	.
cord-006664-ykfvbypo	195	1	Expression	expression	NN
cord-006664-ykfvbypo	195	2	of	of	IN
cord-006664-ykfvbypo	195	3	vascular	vascular	JJ
cord-006664-ykfvbypo	195	4	cell	cell	NN
cord-006664-ykfvbypo	195	5	adhesion	adhesion	NN
cord-006664-ykfvbypo	195	6	molecule	molecule	NN
cord-006664-ykfvbypo	195	7	(	(	-LRB-
cord-006664-ykfvbypo	195	8	VCAM)-1	vcam)-1	NN
cord-006664-ykfvbypo	195	9	is	be	VBZ
cord-006664-ykfvbypo	195	10	also	also	RB
cord-006664-ykfvbypo	195	11	NF	NF	NNP
cord-006664-ykfvbypo	195	12	-	-	HYPH
cord-006664-ykfvbypo	195	13	kb	kb	NNP
cord-006664-ykfvbypo	195	14	dependent	dependent	JJ
cord-006664-ykfvbypo	195	15	.	.	.
cord-006664-ykfvbypo	196	1	90	90	CD
cord-006664-ykfvbypo	196	2	"	"	``
cord-006664-ykfvbypo	196	3	°	°	NN
cord-006664-ykfvbypo	196	4	6	6	CD
cord-006664-ykfvbypo	196	5	Accumulating	accumulate	VBG
cord-006664-ykfvbypo	196	6	evidence	evidence	NN
cord-006664-ykfvbypo	196	7	has	have	VBZ
cord-006664-ykfvbypo	196	8	shown	show	VBN
cord-006664-ykfvbypo	196	9	NF	NF	NNP
cord-006664-ykfvbypo	196	10	-	-	HYPH
cord-006664-ykfvbypo	196	11	kb	kb	NNP
cord-006664-ykfvbypo	196	12	is	be	VBZ
cord-006664-ykfvbypo	196	13	activated	activate	VBN
cord-006664-ykfvbypo	196	14	in	in	IN
cord-006664-ykfvbypo	196	15	both	both	DT
cord-006664-ykfvbypo	196	16	vascular	vascular	JJ
cord-006664-ykfvbypo	196	17	cell	cell	NN
cord-006664-ykfvbypo	196	18	injury	injury	NN
cord-006664-ykfvbypo	196	19	and	and	CC
cord-006664-ykfvbypo	196	20	atherosclerosis	atherosclerosis	NN
cord-006664-ykfvbypo	196	21	.	.	.
cord-006664-ykfvbypo	197	1	91	91	CD
cord-006664-ykfvbypo	197	2	'	'	CD
cord-006664-ykfvbypo	197	3	93	93	CD
cord-006664-ykfvbypo	198	1	In	in	IN
cord-006664-ykfvbypo	198	2	a	a	DT
cord-006664-ykfvbypo	198	3	rat	rat	NN
cord-006664-ykfvbypo	198	4	model	model	NN
cord-006664-ykfvbypo	198	5	of	of	IN
cord-006664-ykfvbypo	198	6	balloon	balloon	NN
cord-006664-ykfvbypo	198	7	catheter	catheter	NN
cord-006664-ykfvbypo	198	8	carotid	carotid	JJ
cord-006664-ykfvbypo	198	9	injury	injury	NN
cord-006664-ykfvbypo	198	10	,	,	,
cord-006664-ykfvbypo	198	11	NF	NF	NNP
cord-006664-ykfvbypo	198	12	-	-	HYPH
cord-006664-ykfvbypo	198	13	kb	kb	NNP
cord-006664-ykfvbypo	198	14	regulated	regulate	VBN
cord-006664-ykfvbypo	198	15	genes	gene	NNS
cord-006664-ykfvbypo	198	16	,	,	,
cord-006664-ykfvbypo	198	17	monocyte	monocyte	NNP
cord-006664-ykfvbypo	198	18	chemoattractant	chemoattractant	NNP
cord-006664-ykfvbypo	198	19	protein	protein	NN
cord-006664-ykfvbypo	198	20	(	(	-LRB-
cord-006664-ykfvbypo	198	21	MCP)-1	MCP)-1	NNP
cord-006664-ykfvbypo	198	22	and	and	CC
cord-006664-ykfvbypo	198	23	VCAM-1	VCAM-1	NNP
cord-006664-ykfvbypo	198	24	were	be	VBD
cord-006664-ykfvbypo	198	25	apparent	apparent	JJ
cord-006664-ykfvbypo	198	26	in	in	IN
cord-006664-ykfvbypo	198	27	smooth	smooth	JJ
cord-006664-ykfvbypo	198	28	muscle	muscle	NN
cord-006664-ykfvbypo	198	29	cells	cell	NNS
cord-006664-ykfvbypo	198	30	within	within	IN
cord-006664-ykfvbypo	198	31	four	four	CD
cord-006664-ykfvbypo	198	32	hours	hour	NNS
cord-006664-ykfvbypo	198	33	.	.	.
cord-006664-ykfvbypo	199	1	This	this	DT
cord-006664-ykfvbypo	199	2	expression	expression	NN
cord-006664-ykfvbypo	199	3	occurred	occur	VBD
cord-006664-ykfvbypo	199	4	in	in	IN
cord-006664-ykfvbypo	199	5	parallel	parallel	NN
cord-006664-ykfvbypo	199	6	with	with	IN
cord-006664-ykfvbypo	199	7	macrophage	macrophage	NN
cord-006664-ykfvbypo	199	8	infiltration	infiltration	NN
cord-006664-ykfvbypo	199	9	.	.	.
cord-006664-ykfvbypo	200	1	This	this	DT
cord-006664-ykfvbypo	200	2	finding	find	VBG
cord-006664-ykfvbypo	200	3	links	link	NNS
cord-006664-ykfvbypo	200	4	NF	NF	NNP
cord-006664-ykfvbypo	200	5	-	-	HYPH
cord-006664-ykfvbypo	200	6	kb	kb	NNP
cord-006664-ykfvbypo	200	7	to	to	IN
cord-006664-ykfvbypo	200	8	the	the	DT
cord-006664-ykfvbypo	200	9	injury	injury	NN
cord-006664-ykfvbypo	200	10	and	and	CC
cord-006664-ykfvbypo	200	11	lesion	lesion	NN
cord-006664-ykfvbypo	200	12	formation	formation	NN
cord-006664-ykfvbypo	200	13	responses	response	NNS
cord-006664-ykfvbypo	200	14	of	of	IN
cord-006664-ykfvbypo	200	15	the	the	DT
cord-006664-ykfvbypo	200	16	endothelium	endothelium	NN
cord-006664-ykfvbypo	200	17	.	.	.
cord-006664-ykfvbypo	201	1	"	"	''
cord-006664-ykfvbypo	202	1	NF	NF	NNP
cord-006664-ykfvbypo	202	2	-	-	HYPH
cord-006664-ykfvbypo	202	3	kb	kb	NNP
cord-006664-ykfvbypo	202	4	plays	play	VBZ
cord-006664-ykfvbypo	202	5	a	a	DT
cord-006664-ykfvbypo	202	6	key	key	JJ
cord-006664-ykfvbypo	202	7	role	role	NN
cord-006664-ykfvbypo	202	8	in	in	IN
cord-006664-ykfvbypo	202	9	regulating	regulate	VBG
cord-006664-ykfvbypo	202	10	vascular	vascular	JJ
cord-006664-ykfvbypo	202	11	smooth	smooth	JJ
cord-006664-ykfvbypo	202	12	muscle	muscle	NN
cord-006664-ykfvbypo	202	13	cell	cell	NN
cord-006664-ykfvbypo	202	14	proliferation	proliferation	NN
cord-006664-ykfvbypo	202	15	in	in	IN
cord-006664-ykfvbypo	202	16	normal	normal	JJ
cord-006664-ykfvbypo	202	17	and	and	CC
cord-006664-ykfvbypo	202	18	damaged	damaged	JJ
cord-006664-ykfvbypo	202	19	endothelium	endothelium	NN
cord-006664-ykfvbypo	202	20	.	.	.
cord-006664-ykfvbypo	203	1	Abnormalities	abnormality	NNS
cord-006664-ykfvbypo	203	2	in	in	IN
cord-006664-ykfvbypo	203	3	the	the	DT
cord-006664-ykfvbypo	203	4	regulatory	regulatory	JJ
cord-006664-ykfvbypo	203	5	processes	process	NNS
cord-006664-ykfvbypo	203	6	of	of	IN
cord-006664-ykfvbypo	203	7	smooth	smooth	JJ
cord-006664-ykfvbypo	203	8	muscle	muscle	NN
cord-006664-ykfvbypo	203	9	and	and	CC
cord-006664-ykfvbypo	203	10	endothelial	endothelial	JJ
cord-006664-ykfvbypo	203	11	cell	cell	NN
cord-006664-ykfvbypo	203	12	proliferation	proliferation	NN
cord-006664-ykfvbypo	203	13	clinically	clinically	RB
cord-006664-ykfvbypo	203	14	produce	produce	VBP
cord-006664-ykfvbypo	203	15	neointimal	neointimal	JJ
cord-006664-ykfvbypo	203	16	hyperplasia	hyperplasia	NN
cord-006664-ykfvbypo	203	17	.	.	.
cord-006664-ykfvbypo	204	1	Its	-PRON-	PRP$
cord-006664-ykfvbypo	204	2	anti	anti	JJ
cord-006664-ykfvbypo	204	3	-	-	JJ
cord-006664-ykfvbypo	204	4	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	204	5	role	role	NN
cord-006664-ykfvbypo	204	6	in	in	IN
cord-006664-ykfvbypo	204	7	such	such	JJ
cord-006664-ykfvbypo	204	8	circumstances	circumstance	NNS
cord-006664-ykfvbypo	204	9	may	may	MD
cord-006664-ykfvbypo	204	10	ultimately	ultimately	RB
cord-006664-ykfvbypo	204	11	be	be	VB
cord-006664-ykfvbypo	204	12	harmful	harmful	JJ
cord-006664-ykfvbypo	204	13	.	.	.
cord-006664-ykfvbypo	205	1	Its	-PRON-	PRP$
cord-006664-ykfvbypo	205	2	upregulation	upregulation	NN
cord-006664-ykfvbypo	205	3	in	in	IN
cord-006664-ykfvbypo	205	4	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	205	5	plaques	plaque	NNS
cord-006664-ykfvbypo	205	6	also	also	RB
cord-006664-ykfvbypo	205	7	suggests	suggest	VBZ
cord-006664-ykfvbypo	205	8	a	a	DT
cord-006664-ykfvbypo	205	9	potential	potential	JJ
cord-006664-ykfvbypo	205	10	role	role	NN
cord-006664-ykfvbypo	205	11	in	in	IN
cord-006664-ykfvbypo	205	12	their	-PRON-	PRP$
cord-006664-ykfvbypo	205	13	pathogenesis	pathogenesis	NN
cord-006664-ykfvbypo	205	14	.	.	.
cord-006664-ykfvbypo	206	1	91	91	CD
cord-006664-ykfvbypo	206	2	,	,	,
cord-006664-ykfvbypo	206	3	92	92	CD
cord-006664-ykfvbypo	206	4	Tumour	tumour	NN
cord-006664-ykfvbypo	206	5	necrosis	necrosis	NN
cord-006664-ykfvbypo	206	6	factor	factor	NN
cord-006664-ykfvbypo	206	7	Tumour	tumour	NN
cord-006664-ykfvbypo	206	8	necrosis	necrosis	NN
cord-006664-ykfvbypo	206	9	factor	factor	NN
cord-006664-ykfvbypo	206	10	(	(	-LRB-
cord-006664-ykfvbypo	206	11	TNF	TNF	NNP
cord-006664-ykfvbypo	206	12	)	)	-RRB-
cord-006664-ykfvbypo	206	13	is	be	VBZ
cord-006664-ykfvbypo	206	14	a	a	DT
cord-006664-ykfvbypo	206	15	potent	potent	JJ
cord-006664-ykfvbypo	206	16	inducer	inducer	NN
cord-006664-ykfvbypo	206	17	of	of	IN
cord-006664-ykfvbypo	206	18	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	206	19	cell	cell	NN
cord-006664-ykfvbypo	206	20	death	death	NN
cord-006664-ykfvbypo	206	21	in	in	IN
cord-006664-ykfvbypo	206	22	many	many	JJ
cord-006664-ykfvbypo	206	23	cell	cell	NN
cord-006664-ykfvbypo	206	24	types	type	NNS
cord-006664-ykfvbypo	206	25	,	,	,
cord-006664-ykfvbypo	206	26	subsequent	subsequent	JJ
cord-006664-ykfvbypo	206	27	to	to	IN
cord-006664-ykfvbypo	206	28	binding	bind	VBG
cord-006664-ykfvbypo	206	29	to	to	IN
cord-006664-ykfvbypo	206	30	its	-PRON-	PRP$
cord-006664-ykfvbypo	206	31	receptor.93	receptor.93	NNP
cord-006664-ykfvbypo	206	32	TNFa	TNFa	NNP
cord-006664-ykfvbypo	206	33	has	have	VBZ
cord-006664-ykfvbypo	206	34	been	be	VBN
cord-006664-ykfvbypo	206	35	shown	show	VBN
cord-006664-ykfvbypo	206	36	to	to	TO
cord-006664-ykfvbypo	206	37	induce	induce	VB
cord-006664-ykfvbypo	206	38	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	206	39	in	in	IN
cord-006664-ykfvbypo	206	40	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	206	41	in	in	IN
cord-006664-ykfvbypo	206	42	vitro	vitro	FW
cord-006664-ykfvbypo	206	43	and	and	CC
cord-006664-ykfvbypo	206	44	in	in	IN
cord-006664-ykfvbypo	206	45	vivo.23'94	vivo.23'94	NNP
cord-006664-ykfvbypo	207	1	Two	two	CD
cord-006664-ykfvbypo	207	2	cell	cell	NN
cord-006664-ykfvbypo	207	3	surface	surface	NN
cord-006664-ykfvbypo	207	4	receptors	receptor	NNS
cord-006664-ykfvbypo	207	5	for	for	IN
cord-006664-ykfvbypo	207	6	TNFa	TNFa	NNS
cord-006664-ykfvbypo	207	7	,	,	,
cord-006664-ykfvbypo	207	8	the	the	DT
cord-006664-ykfvbypo	207	9	55kD	55kd	CD
cord-006664-ykfvbypo	207	10	and	and	CC
cord-006664-ykfvbypo	207	11	75kD	75kd	CD
cord-006664-ykfvbypo	207	12	TNFR1	tnfr1	XX
cord-006664-ykfvbypo	207	13	and	and	CC
cord-006664-ykfvbypo	207	14	TNFR2	tnfr2	NN
cord-006664-ykfvbypo	207	15	,	,	,
cord-006664-ykfvbypo	207	16	respectively	respectively	RB
cord-006664-ykfvbypo	207	17	,	,	,
cord-006664-ykfvbypo	207	18	are	be	VBP
cord-006664-ykfvbypo	207	19	both	both	DT
cord-006664-ykfvbypo	207	20	functionally	functionally	RB
cord-006664-ykfvbypo	207	21	expressed	express	VBN
cord-006664-ykfvbypo	207	22	by	by	IN
cord-006664-ykfvbypo	207	23	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	207	24	in	in	IN
cord-006664-ykfvbypo	207	25	the	the	DT
cord-006664-ykfvbypo	207	26	failing	fail	VBG
cord-006664-ykfvbypo	207	27	myocardium	myocardium	NN
cord-006664-ykfvbypo	207	28	.	.	.
cord-006664-ykfvbypo	208	1	9	9	LS
cord-006664-ykfvbypo	208	2	'	'	''
cord-006664-ykfvbypo	209	1	Fas	Fas	NNP
cord-006664-ykfvbypo	209	2	expression	expression	NN
cord-006664-ykfvbypo	209	3	in	in	IN
cord-006664-ykfvbypo	209	4	the	the	DT
cord-006664-ykfvbypo	209	5	murine	murine	JJ
cord-006664-ykfvbypo	209	6	myocardium	myocardium	NN
cord-006664-ykfvbypo	209	7	has	have	VBZ
cord-006664-ykfvbypo	209	8	been	be	VBN
cord-006664-ykfvbypo	209	9	found	find	VBN
cord-006664-ykfvbypo	209	10	to	to	TO
cord-006664-ykfvbypo	209	11	be	be	VB
cord-006664-ykfvbypo	209	12	enhanced	enhance	VBN
cord-006664-ykfvbypo	209	13	in	in	IN
cord-006664-ykfvbypo	209	14	models	model	NNS
cord-006664-ykfvbypo	209	15	of	of	IN
cord-006664-ykfvbypo	209	16	viral	viral	JJ
cord-006664-ykfvbypo	209	17	congestive	congestive	JJ
cord-006664-ykfvbypo	209	18	cardiac	cardiac	JJ
cord-006664-ykfvbypo	209	19	failure	failure	NN
cord-006664-ykfvbypo	209	20	and	and	CC
cord-006664-ykfvbypo	209	21	this	this	DT
cord-006664-ykfvbypo	209	22	was	be	VBD
cord-006664-ykfvbypo	209	23	associated	associate	VBN
cord-006664-ykfvbypo	209	24	with	with	IN
cord-006664-ykfvbypo	209	25	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	209	26	of	of	IN
cord-006664-ykfvbypo	209	27	inflammatory	inflammatory	JJ
cord-006664-ykfvbypo	209	28	cells	cell	NNS
cord-006664-ykfvbypo	209	29	and	and	CC
cord-006664-ykfvbypo	209	30	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	209	31	.	.	.
cord-006664-ykfvbypo	210	1	96	96	CD
cord-006664-ykfvbypo	211	1	Fas	Fas	NNP
cord-006664-ykfvbypo	211	2	expression	expression	NN
cord-006664-ykfvbypo	211	3	is	be	VBZ
cord-006664-ykfvbypo	211	4	also	also	RB
cord-006664-ykfvbypo	211	5	upregulated	upregulate	VBN
cord-006664-ykfvbypo	211	6	in	in	IN
cord-006664-ykfvbypo	211	7	coronary	coronary	JJ
cord-006664-ykfvbypo	211	8	artery	artery	NN
cord-006664-ykfvbypo	211	9	ligation	ligation	NN
cord-006664-ykfvbypo	211	10	.	.	.
cord-006664-ykfvbypo	212	1	'	'	''
cord-006664-ykfvbypo	212	2	$	$	$
cord-006664-ykfvbypo	213	1	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	213	2	in	in	IN
cord-006664-ykfvbypo	213	3	the	the	DT
cord-006664-ykfvbypo	213	4	normal	normal	JJ
cord-006664-ykfvbypo	213	5	cardiovascular	cardiovascular	JJ
cord-006664-ykfvbypo	213	6	system	system	NN
cord-006664-ykfvbypo	214	1	In	in	IN
cord-006664-ykfvbypo	214	2	the	the	DT
cord-006664-ykfvbypo	214	3	cardiovascular	cardiovascular	JJ
cord-006664-ykfvbypo	214	4	system	system	NN
cord-006664-ykfvbypo	214	5	,	,	,
cord-006664-ykfvbypo	214	6	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	214	7	is	be	VBZ
cord-006664-ykfvbypo	214	8	first	first	RB
cord-006664-ykfvbypo	214	9	seen	see	VBN
cord-006664-ykfvbypo	214	10	during	during	IN
cord-006664-ykfvbypo	214	11	embryogenesis	embryogenesis	NN
cord-006664-ykfvbypo	214	12	with	with	IN
cord-006664-ykfvbypo	214	13	remodelling	remodelling	NN
cord-006664-ykfvbypo	214	14	of	of	IN
cord-006664-ykfvbypo	214	15	the	the	DT
cord-006664-ykfvbypo	214	16	bulbis	bulbis	NNP
cord-006664-ykfvbypo	214	17	cordis	cordis	NNP
cord-006664-ykfvbypo	214	18	and	and	CC
cord-006664-ykfvbypo	214	19	atrioventricular	atrioventricular	JJ
cord-006664-ykfvbypo	214	20	cushions	cushion	NNS
cord-006664-ykfvbypo	214	21	by	by	IN
cord-006664-ykfvbypo	214	22	programmed	programmed	JJ
cord-006664-ykfvbypo	214	23	cell	cell	NN
cord-006664-ykfvbypo	214	24	death	death	NN
cord-006664-ykfvbypo	214	25	.	.	.
cord-006664-ykfvbypo	214	26	'	'	''
cord-006664-ykfvbypo	215	1	Postnatal	postnatal	JJ
cord-006664-ykfvbypo	215	2	cardiac	cardiac	JJ
cord-006664-ykfvbypo	215	3	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	215	4	cell	cell	NN
cord-006664-ykfvbypo	215	5	death	death	NN
cord-006664-ykfvbypo	215	6	is	be	VBZ
cord-006664-ykfvbypo	215	7	expressed	express	VBN
cord-006664-ykfvbypo	215	8	preferentially	preferentially	RB
cord-006664-ykfvbypo	215	9	in	in	IN
cord-006664-ykfvbypo	215	10	the	the	DT
cord-006664-ykfvbypo	215	11	right	right	JJ
cord-006664-ykfvbypo	215	12	ventricle	ventricle	NN
cord-006664-ykfvbypo	215	13	,	,	,
cord-006664-ykfvbypo	215	14	with	with	IN
cord-006664-ykfvbypo	215	15	the	the	DT
cord-006664-ykfvbypo	215	16	resultant	resultant	JJ
cord-006664-ykfvbypo	215	17	reduced	reduce	VBN
cord-006664-ykfvbypo	215	18	right	right	JJ
cord-006664-ykfvbypo	215	19	chamber	chamber	NN
cord-006664-ykfvbypo	215	20	muscle	muscle	NN
cord-006664-ykfvbypo	215	21	mass	mass	NN
cord-006664-ykfvbypo	215	22	accompanying	accompany	VBG
cord-006664-ykfvbypo	215	23	the	the	DT
cord-006664-ykfvbypo	215	24	transition	transition	NN
cord-006664-ykfvbypo	215	25	to	to	IN
cord-006664-ykfvbypo	215	26	an	an	DT
cord-006664-ykfvbypo	215	27	adult	adult	NN
cord-006664-ykfvbypo	215	28	circulatory	circulatory	JJ
cord-006664-ykfvbypo	215	29	system	system	NN
cord-006664-ykfvbypo	215	30	.	.	.
cord-006664-ykfvbypo	216	1	"	"	''
cord-006664-ykfvbypo	217	1	This	this	DT
cord-006664-ykfvbypo	217	2	cardiac	cardiac	JJ
cord-006664-ykfvbypo	217	3	remodelling	remodelling	NN
cord-006664-ykfvbypo	217	4	is	be	VBZ
cord-006664-ykfvbypo	217	5	associated	associate	VBN
cord-006664-ykfvbypo	217	6	with	with	IN
cord-006664-ykfvbypo	217	7	and	and	CC
cord-006664-ykfvbypo	217	8	facilitated	facilitate	VBN
cord-006664-ykfvbypo	217	9	by	by	IN
cord-006664-ykfvbypo	217	10	diminished	diminished	JJ
cord-006664-ykfvbypo	217	11	expression	expression	NN
cord-006664-ykfvbypo	217	12	of	of	IN
cord-006664-ykfvbypo	217	13	the	the	DT
cord-006664-ykfvbypo	217	14	anti	anti	JJ
cord-006664-ykfvbypo	217	15	-	-	JJ
cord-006664-ykfvbypo	217	16	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	217	17	_	_	NNP
cord-006664-ykfvbypo	217	18	gene	gene	NN
cord-006664-ykfvbypo	217	19	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	217	20	.	.	.
cord-006664-ykfvbypo	218	1	8	8	CD
cord-006664-ykfvbypo	219	1	The	the	DT
cord-006664-ykfvbypo	219	2	development	development	NN
cord-006664-ykfvbypo	219	3	of	of	IN
cord-006664-ykfvbypo	219	4	the	the	DT
cord-006664-ykfvbypo	219	5	cardiac	cardiac	JJ
cord-006664-ykfvbypo	219	6	conductive	conductive	JJ
cord-006664-ykfvbypo	219	7	system	system	NN
cord-006664-ykfvbypo	219	8	of	of	IN
cord-006664-ykfvbypo	219	9	pathways	pathway	NNS
cord-006664-ykfvbypo	219	10	also	also	RB
cord-006664-ykfvbypo	219	11	employs	employ	VBZ
cord-006664-ykfvbypo	219	12	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	219	13	in	in	IN
cord-006664-ykfvbypo	219	14	deleting	delete	VBG
cord-006664-ykfvbypo	219	15	unnecessary	unnecessary	JJ
cord-006664-ykfvbypo	219	16	cells	cell	NNS
cord-006664-ykfvbypo	219	17	.	.	.
cord-006664-ykfvbypo	220	1	98	98	CD
cord-006664-ykfvbypo	221	1	Aberrant	aberrant	JJ
cord-006664-ykfvbypo	221	2	persistent	persistent	JJ
cord-006664-ykfvbypo	221	3	atrioventricular	atrioventricular	JJ
cord-006664-ykfvbypo	221	4	conductive	conductive	JJ
cord-006664-ykfvbypo	221	5	pathways	pathway	NNS
cord-006664-ykfvbypo	221	6	,	,	,
cord-006664-ykfvbypo	221	7	which	which	WDT
cord-006664-ykfvbypo	221	8	would	would	MD
cord-006664-ykfvbypo	221	9	normally	normally	RB
cord-006664-ykfvbypo	221	10	be	be	VB
cord-006664-ykfvbypo	221	11	removed	remove	VBN
cord-006664-ykfvbypo	221	12	by	by	IN
cord-006664-ykfvbypo	221	13	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	221	14	,	,	,
cord-006664-ykfvbypo	221	15	have	have	VBP
cord-006664-ykfvbypo	221	16	been	be	VBN
cord-006664-ykfvbypo	221	17	suggested	suggest	VBN
cord-006664-ykfvbypo	221	18	as	as	IN
cord-006664-ykfvbypo	221	19	a	a	DT
cord-006664-ykfvbypo	221	20	potential	potential	JJ
cord-006664-ykfvbypo	221	21	cause	cause	NN
cord-006664-ykfvbypo	221	22	of	of	IN
cord-006664-ykfvbypo	221	23	abnormalities	abnormality	NNS
cord-006664-ykfvbypo	221	24	such	such	JJ
cord-006664-ykfvbypo	221	25	as	as	IN
cord-006664-ykfvbypo	221	26	Wolff	Wolff	NNP
cord-006664-ykfvbypo	221	27	-	-	HYPH
cord-006664-ykfvbypo	221	28	Parkinson	Parkinson	NNP
cord-006664-ykfvbypo	221	29	-	-	HYPH
cord-006664-ykfvbypo	221	30	White	White	NNP
cord-006664-ykfvbypo	221	31	syndrome	syndrome	NN
cord-006664-ykfvbypo	221	32	.	.	.
cord-006664-ykfvbypo	221	33	'	'	''
cord-006664-ykfvbypo	222	1	2	2	LS
cord-006664-ykfvbypo	222	2	'	'	''
cord-006664-ykfvbypo	223	1	The	the	DT
cord-006664-ykfvbypo	223	2	postnatal	postnatal	JJ
cord-006664-ykfvbypo	223	3	development	development	NN
cord-006664-ykfvbypo	223	4	of	of	IN
cord-006664-ykfvbypo	223	5	the	the	DT
cord-006664-ykfvbypo	223	6	vascular	vascular	JJ
cord-006664-ykfvbypo	223	7	system	system	NN
cord-006664-ykfvbypo	223	8	involves	involve	VBZ
cord-006664-ykfvbypo	223	9	cell	cell	NN
cord-006664-ykfvbypo	223	10	death	death	NN
cord-006664-ykfvbypo	223	11	by	by	IN
cord-006664-ykfvbypo	223	12	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	223	13	in	in	IN
cord-006664-ykfvbypo	223	14	vessel	vessel	NN
cord-006664-ykfvbypo	223	15	remodelling	remodelling	NN
cord-006664-ykfvbypo	223	16	.	.	.
cord-006664-ykfvbypo	223	17	"	"	''
cord-006664-ykfvbypo	223	18	,	,	,
cord-006664-ykfvbypo	223	19	'	'	''
cord-006664-ykfvbypo	223	20	°	°	NN
cord-006664-ykfvbypo	223	21	°	°	NN
cord-006664-ykfvbypo	224	1	In	in	IN
cord-006664-ykfvbypo	224	2	an	an	DT
cord-006664-ykfvbypo	224	3	analogous	analogous	JJ
cord-006664-ykfvbypo	224	4	situation	situation	NN
cord-006664-ykfvbypo	224	5	,	,	,
cord-006664-ykfvbypo	224	6	the	the	DT
cord-006664-ykfvbypo	224	7	vascular	vascular	JJ
cord-006664-ykfvbypo	224	8	endothelial	endothelial	JJ
cord-006664-ykfvbypo	224	9	post	post	JJ
cord-006664-ykfvbypo	224	10	-	-	JJ
cord-006664-ykfvbypo	224	11	injury	injury	JJ
cord-006664-ykfvbypo	224	12	response	response	NN
cord-006664-ykfvbypo	224	13	relies	rely	VBZ
cord-006664-ykfvbypo	224	14	on	on	IN
cord-006664-ykfvbypo	224	15	homeostasis	homeostasis	NN
cord-006664-ykfvbypo	224	16	between	between	IN
cord-006664-ykfvbypo	224	17	proliferation	proliferation	NN
cord-006664-ykfvbypo	224	18	and	and	CC
cord-006664-ykfvbypo	224	19	remodelling	remodelling	NN
cord-006664-ykfvbypo	224	20	by	by	IN
cord-006664-ykfvbypo	224	21	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	224	22	cell	cell	NN
cord-006664-ykfvbypo	224	23	deletion	deletion	NN
cord-006664-ykfvbypo	224	24	in	in	IN
cord-006664-ykfvbypo	224	25	order	order	NN
cord-006664-ykfvbypo	224	26	to	to	TO
cord-006664-ykfvbypo	224	27	prevent	prevent	VB
cord-006664-ykfvbypo	224	28	excessive	excessive	JJ
cord-006664-ykfvbypo	224	29	neointimal	neointimal	JJ
cord-006664-ykfvbypo	224	30	hyperplasia	hyperplasia	NN
cord-006664-ykfvbypo	224	31	.	.	.
cord-006664-ykfvbypo	225	1	'	'	``
cord-006664-ykfvbypo	225	2	°	°	NNS
cord-006664-ykfvbypo	225	3	'	'	''
cord-006664-ykfvbypo	225	4	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	225	5	in	in	IN
cord-006664-ykfvbypo	225	6	ischaemia	ischaemia	NN
cord-006664-ykfvbypo	225	7	-	-	HYPH
cord-006664-ykfvbypo	225	8	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	225	9	(	(	-LRB-
cord-006664-ykfvbypo	225	10	1R	1r	NN
cord-006664-ykfvbypo	225	11	)	)	-RRB-
cord-006664-ykfvbypo	226	1	The	the	DT
cord-006664-ykfvbypo	226	2	vascular	vascular	JJ
cord-006664-ykfvbypo	226	3	endothelium	endothelium	NN
cord-006664-ykfvbypo	226	4	,	,	,
cord-006664-ykfvbypo	226	5	by	by	IN
cord-006664-ykfvbypo	226	6	virtue	virtue	NN
cord-006664-ykfvbypo	226	7	of	of	IN
cord-006664-ykfvbypo	226	8	its	-PRON-	PRP$
cord-006664-ykfvbypo	226	9	location	location	NN
cord-006664-ykfvbypo	226	10	at	at	IN
cord-006664-ykfvbypo	226	11	the	the	DT
cord-006664-ykfvbypo	226	12	blood	blood	NN
cord-006664-ykfvbypo	226	13	-	-	HYPH
cord-006664-ykfvbypo	226	14	tissue	tissue	NN
cord-006664-ykfvbypo	226	15	interface	interface	NN
cord-006664-ykfvbypo	226	16	,	,	,
cord-006664-ykfvbypo	226	17	is	be	VBZ
cord-006664-ykfvbypo	226	18	in	in	IN
cord-006664-ykfvbypo	226	19	the	the	DT
cord-006664-ykfvbypo	226	20	front	front	JJ
cord-006664-ykfvbypo	226	21	line	line	NN
cord-006664-ykfvbypo	226	22	of	of	IN
cord-006664-ykfvbypo	226	23	IR	IR	NNP
cord-006664-ykfvbypo	226	24	injury	injury	NN
cord-006664-ykfvbypo	226	25	.	.	.
cord-006664-ykfvbypo	227	1	Reperfusion	reperfusion	NN
cord-006664-ykfvbypo	227	2	of	of	IN
cord-006664-ykfvbypo	227	3	ischaemic	ischaemic	JJ
cord-006664-ykfvbypo	227	4	tissues	tissue	NNS
cord-006664-ykfvbypo	227	5	is	be	VBZ
cord-006664-ykfvbypo	227	6	a	a	DT
cord-006664-ykfvbypo	227	7	consistent	consistent	JJ
cord-006664-ykfvbypo	227	8	aim	aim	NN
cord-006664-ykfvbypo	227	9	of	of	IN
cord-006664-ykfvbypo	227	10	clinical	clinical	JJ
cord-006664-ykfvbypo	227	11	therapies	therapy	NNS
cord-006664-ykfvbypo	227	12	.	.	.
cord-006664-ykfvbypo	228	1	However	however	RB
cord-006664-ykfvbypo	228	2	,	,	,
cord-006664-ykfvbypo	228	3	as	as	IN
cord-006664-ykfvbypo	228	4	Parks	Parks	NNPS
cord-006664-ykfvbypo	228	5	and	and	CC
cord-006664-ykfvbypo	228	6	Granger102	Granger102	NNP
cord-006664-ykfvbypo	228	7	showed	show	VBD
cord-006664-ykfvbypo	228	8	,	,	,
cord-006664-ykfvbypo	228	9	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	228	10	is	be	VBZ
cord-006664-ykfvbypo	228	11	a	a	DT
cord-006664-ykfvbypo	228	12	double	double	RB
cord-006664-ykfvbypo	228	13	-	-	HYPH
cord-006664-ykfvbypo	228	14	edged	edged	JJ
cord-006664-ykfvbypo	228	15	sword	sword	NN
cord-006664-ykfvbypo	228	16	which	which	WDT
cord-006664-ykfvbypo	228	17	can	can	MD
cord-006664-ykfvbypo	228	18	exacerbate	exacerbate	VB
cord-006664-ykfvbypo	228	19	the	the	DT
cord-006664-ykfvbypo	228	20	initial	initial	JJ
cord-006664-ykfvbypo	228	21	hypoxic	hypoxic	JJ
cord-006664-ykfvbypo	228	22	injury	injury	NN
cord-006664-ykfvbypo	228	23	.	.	.
cord-006664-ykfvbypo	229	1	Reactive	reactive	JJ
cord-006664-ykfvbypo	229	2	oxygen	oxygen	NN
cord-006664-ykfvbypo	229	3	species	specie	NNS
cord-006664-ykfvbypo	229	4	such	such	JJ
cord-006664-ykfvbypo	229	5	as	as	IN
cord-006664-ykfvbypo	229	6	superoxide	superoxide	NN
cord-006664-ykfvbypo	229	7	,	,	,
cord-006664-ykfvbypo	229	8	NO	no	UH
cord-006664-ykfvbypo	229	9	,	,	,
cord-006664-ykfvbypo	229	10	hydrogen	hydrogen	NN
cord-006664-ykfvbypo	229	11	peroxide	peroxide	NN
cord-006664-ykfvbypo	229	12	,	,	,
cord-006664-ykfvbypo	229	13	lipid	lipid	NN
cord-006664-ykfvbypo	229	14	peroxides	peroxide	NNS
cord-006664-ykfvbypo	229	15	and	and	CC
cord-006664-ykfvbypo	229	16	the	the	DT
cord-006664-ykfvbypo	229	17	hydroxyl	hydroxyl	NN
cord-006664-ykfvbypo	229	18	radical	radical	JJ
cord-006664-ykfvbypo	229	19	generated	generate	VBN
cord-006664-ykfvbypo	229	20	in	in	IN
cord-006664-ykfvbypo	229	21	excess	excess	NN
cord-006664-ykfvbypo	229	22	during	during	IN
cord-006664-ykfvbypo	229	23	IR	IR	NNP
cord-006664-ykfvbypo	229	24	injury	injury	NN
cord-006664-ykfvbypo	229	25	can	can	MD
cord-006664-ykfvbypo	229	26	subject	subject	VB
cord-006664-ykfvbypo	229	27	a	a	DT
cord-006664-ykfvbypo	229	28	cell	cell	NN
cord-006664-ykfvbypo	229	29	to	to	IN
cord-006664-ykfvbypo	229	30	oxidative	oxidative	JJ
cord-006664-ykfvbypo	229	31	stress	stress	NN
cord-006664-ykfvbypo	229	32	and	and	CC
cord-006664-ykfvbypo	229	33	subsequent	subsequent	JJ
cord-006664-ykfvbypo	229	34	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	229	35	.	.	.
cord-006664-ykfvbypo	230	1	103	103	CD
cord-006664-ykfvbypo	231	1	In	in	IN
cord-006664-ykfvbypo	231	2	addition	addition	NN
cord-006664-ykfvbypo	231	3	to	to	IN
cord-006664-ykfvbypo	231	4	the	the	DT
cord-006664-ykfvbypo	231	5	reactive	reactive	JJ
cord-006664-ykfvbypo	231	6	oxygen	oxygen	NN
cord-006664-ykfvbypo	231	7	species	specie	NNS
cord-006664-ykfvbypo	231	8	,	,	,
cord-006664-ykfvbypo	231	9	other	other	JJ
cord-006664-ykfvbypo	231	10	elements	element	NNS
cord-006664-ykfvbypo	231	11	of	of	IN
cord-006664-ykfvbypo	231	12	the	the	DT
cord-006664-ykfvbypo	231	13	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	231	14	injury	injury	NN
cord-006664-ykfvbypo	231	15	which	which	WDT
cord-006664-ykfvbypo	231	16	are	be	VBP
cord-006664-ykfvbypo	231	17	known	know	VBN
cord-006664-ykfvbypo	231	18	to	to	TO
cord-006664-ykfvbypo	231	19	cause	cause	VB
cord-006664-ykfvbypo	231	20	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	231	21	include	include	VBP
cord-006664-ykfvbypo	231	22	alterations	alteration	NNS
cord-006664-ykfvbypo	231	23	in	in	IN
cord-006664-ykfvbypo	231	24	intracellular	intracellular	JJ
cord-006664-ykfvbypo	231	25	calcium	calcium	NN
cord-006664-ykfvbypo	231	26	homeostasis	homeostasis	NN
cord-006664-ykfvbypo	231	27	,	,	,
cord-006664-ykfvbypo	231	28	43	43	CD
cord-006664-ykfvbypo	231	29	,	,	,
cord-006664-ykfvbypo	231	30	'	'	''
cord-006664-ykfvbypo	231	31	°	°	NN
cord-006664-ykfvbypo	231	32	4	4	CD
cord-006664-ykfvbypo	231	33	an	an	DT
cord-006664-ykfvbypo	231	34	inflammatory	inflammatory	JJ
cord-006664-ykfvbypo	231	35	reactiontr	reactiontr	NN
cord-006664-ykfvbypo	231	36	"	"	''
cord-006664-ykfvbypo	231	37	and	and	CC
cord-006664-ykfvbypo	231	38	increased	increase	VBN
cord-006664-ykfvbypo	231	39	mechanical	mechanical	JJ
cord-006664-ykfvbypo	231	40	stretch	stretch	NN
cord-006664-ykfvbypo	231	41	.	.	.
cord-006664-ykfvbypo	232	1	'	'	``
cord-006664-ykfvbypo	232	2	°	°	NNS
cord-006664-ykfvbypo	232	3	'	'	''
cord-006664-ykfvbypo	232	4	The	the	DT
cord-006664-ykfvbypo	232	5	presence	presence	NN
cord-006664-ykfvbypo	232	6	of	of	IN
cord-006664-ykfvbypo	232	7	similar	similar	JJ
cord-006664-ykfvbypo	232	8	mediators	mediator	NNS
cord-006664-ykfvbypo	232	9	in	in	IN
cord-006664-ykfvbypo	232	10	other	other	JJ
cord-006664-ykfvbypo	232	11	contexts	contexts	NN
cord-006664-ykfvbypo	232	12	leads	lead	VBZ
cord-006664-ykfvbypo	232	13	on	on	RP
cord-006664-ykfvbypo	232	14	to	to	IN
cord-006664-ykfvbypo	232	15	a	a	DT
cord-006664-ykfvbypo	232	16	potential	potential	JJ
cord-006664-ykfvbypo	232	17	role	role	NN
cord-006664-ykfvbypo	232	18	for	for	IN
cord-006664-ykfvbypo	232	19	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	232	20	in	in	IN
cord-006664-ykfvbypo	232	21	mediating	mediate	VBG
cord-006664-ykfvbypo	232	22	some	some	DT
cord-006664-ykfvbypo	232	23	of	of	IN
cord-006664-ykfvbypo	232	24	the	the	DT
cord-006664-ykfvbypo	232	25	clinically	clinically	RB
cord-006664-ykfvbypo	232	26	relevant	relevant	JJ
cord-006664-ykfvbypo	232	27	effects	effect	NNS
cord-006664-ykfvbypo	232	28	of	of	IN
cord-006664-ykfvbypo	232	29	local	local	JJ
cord-006664-ykfvbypo	232	30	and	and	CC
cord-006664-ykfvbypo	232	31	systemic	systemic	JJ
cord-006664-ykfvbypo	232	32	IR	IR	NNP
cord-006664-ykfvbypo	232	33	injury	injury	NN
cord-006664-ykfvbypo	232	34	,	,	,
cord-006664-ykfvbypo	232	35	as	as	RB
cord-006664-ykfvbypo	232	36	well	well	RB
cord-006664-ykfvbypo	232	37	as	as	IN
cord-006664-ykfvbypo	232	38	the	the	DT
cord-006664-ykfvbypo	232	39	systemic	systemic	JJ
cord-006664-ykfvbypo	232	40	inflammatory	inflammatory	JJ
cord-006664-ykfvbypo	232	41	response	response	NN
cord-006664-ykfvbypo	232	42	syndrome	syndrome	NN
cord-006664-ykfvbypo	232	43	(	(	-LRB-
cord-006664-ykfvbypo	232	44	SIRS	SIRS	NNP
cord-006664-ykfvbypo	232	45	)	)	-RRB-
cord-006664-ykfvbypo	232	46	.	.	.
cord-006664-ykfvbypo	233	1	The	the	DT
cord-006664-ykfvbypo	233	2	synergistic	synergistic	JJ
cord-006664-ykfvbypo	233	3	dual	dual	JJ
cord-006664-ykfvbypo	233	4	effect	effect	NN
cord-006664-ykfvbypo	233	5	produced	produce	VBN
cord-006664-ykfvbypo	233	6	under	under	IN
cord-006664-ykfvbypo	233	7	such	such	JJ
cord-006664-ykfvbypo	233	8	circumstances	circumstance	NNS
cord-006664-ykfvbypo	233	9	results	result	NNS
cord-006664-ykfvbypo	233	10	in	in	IN
cord-006664-ykfvbypo	233	11	initial	initial	JJ
cord-006664-ykfvbypo	233	12	vascular	vascular	JJ
cord-006664-ykfvbypo	233	13	endothelial	endothelial	JJ
cord-006664-ykfvbypo	233	14	damage	damage	NN
cord-006664-ykfvbypo	233	15	and	and	CC
cord-006664-ykfvbypo	233	16	ultimately	ultimately	RB
cord-006664-ykfvbypo	233	17	end	end	VBP
cord-006664-ykfvbypo	233	18	organ	organ	NN
cord-006664-ykfvbypo	233	19	injury	injury	NN
cord-006664-ykfvbypo	233	20	.	.	.
cord-006664-ykfvbypo	234	1	An	an	DT
cord-006664-ykfvbypo	234	2	analogous	analogous	JJ
cord-006664-ykfvbypo	234	3	situation	situation	NN
cord-006664-ykfvbypo	234	4	occurs	occur	VBZ
cord-006664-ykfvbypo	234	5	in	in	IN
cord-006664-ykfvbypo	234	6	the	the	DT
cord-006664-ykfvbypo	234	7	failing	fail	VBG
cord-006664-ykfvbypo	234	8	myocardium	myocardium	NN
cord-006664-ykfvbypo	234	9	where	where	WRB
cord-006664-ykfvbypo	234	10	reactive	reactive	JJ
cord-006664-ykfvbypo	234	11	oxygen	oxygen	NN
cord-006664-ykfvbypo	234	12	species	specie	NNS
cord-006664-ykfvbypo	234	13	,	,	,
cord-006664-ykfvbypo	234	14	inflammatory	inflammatory	JJ
cord-006664-ykfvbypo	234	15	cytokines	cytokine	NNS
cord-006664-ykfvbypo	234	16	,	,	,
cord-006664-ykfvbypo	234	17	NO	no	UH
cord-006664-ykfvbypo	234	18	,	,	,
cord-006664-ykfvbypo	234	19	hypoxia	hypoxia	NN
cord-006664-ykfvbypo	234	20	,	,	,
cord-006664-ykfvbypo	234	21	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	234	22	and	and	CC
cord-006664-ykfvbypo	234	23	mechanical	mechanical	JJ
cord-006664-ykfvbypo	234	24	stretch	stretch	NN
cord-006664-ykfvbypo	234	25	exert	exert	VBP
cord-006664-ykfvbypo	234	26	pro	pro	JJ
cord-006664-ykfvbypo	234	27	-	-	JJ
cord-006664-ykfvbypo	234	28	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	234	29	influences	influence	NNS
cord-006664-ykfvbypo	234	30	upon	upon	IN
cord-006664-ykfvbypo	234	31	the	the	DT
cord-006664-ykfvbypo	234	32	endothelium	endothelium	NN
cord-006664-ykfvbypo	234	33	and	and	CC
cord-006664-ykfvbypo	234	34	cardiomyocyte	cardiomyocyte	NN
cord-006664-ykfvbypo	234	35	.	.	.
cord-006664-ykfvbypo	234	36	"	"	''
cord-006664-ykfvbypo	235	1	"	"	``
cord-006664-ykfvbypo	235	2	°	°	JJ
cord-006664-ykfvbypo	235	3	7	7	CD
cord-006664-ykfvbypo	235	4	Autopsy	autopsy	JJ
cord-006664-ykfvbypo	235	5	studies	study	NNS
cord-006664-ykfvbypo	235	6	of	of	IN
cord-006664-ykfvbypo	235	7	post	post	JJ
cord-006664-ykfvbypo	235	8	-	-	JJ
cord-006664-ykfvbypo	235	9	myocardial	myocardial	JJ
cord-006664-ykfvbypo	235	10	infarction	infarction	NN
cord-006664-ykfvbypo	235	11	patients	patient	NNS
cord-006664-ykfvbypo	235	12	,	,	,
cord-006664-ykfvbypo	235	13	who	who	WP
cord-006664-ykfvbypo	235	14	had	have	VBD
cord-006664-ykfvbypo	235	15	initially	initially	RB
cord-006664-ykfvbypo	235	16	successful	successful	JJ
cord-006664-ykfvbypo	235	17	thrombolysis	thrombolysis	NN
cord-006664-ykfvbypo	235	18	and	and	CC
cord-006664-ykfvbypo	235	19	therefore	therefore	RB
cord-006664-ykfvbypo	235	20	a	a	DT
cord-006664-ykfvbypo	235	21	patent	patent	NN
cord-006664-ykfvbypo	235	22	infarct	infarct	NN
cord-006664-ykfvbypo	235	23	-	-	HYPH
cord-006664-ykfvbypo	235	24	related	relate	VBN
cord-006664-ykfvbypo	235	25	artery	artery	NN
cord-006664-ykfvbypo	235	26	,	,	,
cord-006664-ykfvbypo	235	27	showed	show	VBD
cord-006664-ykfvbypo	235	28	a	a	DT
cord-006664-ykfvbypo	235	29	clear	clear	JJ
cord-006664-ykfvbypo	235	30	subset	subset	NN
cord-006664-ykfvbypo	235	31	of	of	IN
cord-006664-ykfvbypo	235	32	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	235	33	dying	die	VBG
cord-006664-ykfvbypo	235	34	by	by	IN
cord-006664-ykfvbypo	235	35	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	235	36	as	as	IN
cord-006664-ykfvbypo	235	37	a	a	DT
cord-006664-ykfvbypo	235	38	result	result	NN
cord-006664-ykfvbypo	235	39	of	of	IN
cord-006664-ykfvbypo	235	40	IR	IR	NNP
cord-006664-ykfvbypo	235	41	.	.	.
cord-006664-ykfvbypo	236	1	108	108	CD
cord-006664-ykfvbypo	237	1	This	this	DT
cord-006664-ykfvbypo	237	2	finding	finding	NN
cord-006664-ykfvbypo	237	3	is	be	VBZ
cord-006664-ykfvbypo	237	4	also	also	RB
cord-006664-ykfvbypo	237	5	seen	see	VBN
cord-006664-ykfvbypo	237	6	in	in	IN
cord-006664-ykfvbypo	237	7	experimental	experimental	JJ
cord-006664-ykfvbypo	237	8	animal	animal	NN
cord-006664-ykfvbypo	237	9	models	model	NNS
cord-006664-ykfvbypo	237	10	of	of	IN
cord-006664-ykfvbypo	237	11	IR	IR	NNP
cord-006664-ykfvbypo	237	12	.	.	.
cord-006664-ykfvbypo	238	1	`	`	''
cord-006664-ykfvbypo	238	2	4	4	CD
cord-006664-ykfvbypo	239	1	Because	because	IN
cord-006664-ykfvbypo	239	2	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	239	3	after	after	IN
cord-006664-ykfvbypo	239	4	infarction	infarction	NN
cord-006664-ykfvbypo	239	5	is	be	VBZ
cord-006664-ykfvbypo	239	6	an	an	DT
cord-006664-ykfvbypo	239	7	energy	energy	NN
cord-006664-ykfvbypo	239	8	-	-	HYPH
cord-006664-ykfvbypo	239	9	dependent	dependent	JJ
cord-006664-ykfvbypo	239	10	process	process	NN
cord-006664-ykfvbypo	239	11	relying	rely	VBG
cord-006664-ykfvbypo	239	12	on	on	IN
cord-006664-ykfvbypo	239	13	circulatory	circulatory	JJ
cord-006664-ykfvbypo	239	14	nutrient	nutrient	NN
cord-006664-ykfvbypo	239	15	supply	supply	NN
cord-006664-ykfvbypo	239	16	,	,	,
cord-006664-ykfvbypo	239	17	it	-PRON-	PRP
cord-006664-ykfvbypo	239	18	will	will	MD
cord-006664-ykfvbypo	239	19	occur	occur	VB
cord-006664-ykfvbypo	239	20	primarily	primarily	RB
cord-006664-ykfvbypo	239	21	in	in	IN
cord-006664-ykfvbypo	239	22	reperfused	reperfused	JJ
cord-006664-ykfvbypo	239	23	or	or	CC
cord-006664-ykfvbypo	239	24	watershed	watershed	JJ
cord-006664-ykfvbypo	239	25	areas	area	NNS
cord-006664-ykfvbypo	239	26	of	of	IN
cord-006664-ykfvbypo	239	27	the	the	DT
cord-006664-ykfvbypo	239	28	infarct	infarct	NN
cord-006664-ykfvbypo	239	29	.	.	.
cord-006664-ykfvbypo	240	1	21	21	CD
cord-006664-ykfvbypo	240	2	Studies	study	NNS
cord-006664-ykfvbypo	240	3	have	have	VBP
cord-006664-ykfvbypo	240	4	shown	show	VBN
cord-006664-ykfvbypo	240	5	that	that	IN
cord-006664-ykfvbypo	240	6	myocardial	myocardial	JJ
cord-006664-ykfvbypo	240	7	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	240	8	does	do	VBZ
cord-006664-ykfvbypo	240	9	not	not	RB
cord-006664-ykfvbypo	240	10	occur	occur	VB
cord-006664-ykfvbypo	240	11	in	in	IN
cord-006664-ykfvbypo	240	12	purely	purely	RB
cord-006664-ykfvbypo	240	13	ischaemic	ischaemic	JJ
cord-006664-ykfvbypo	240	14	areas	area	NNS
cord-006664-ykfvbypo	240	15	,	,	,
cord-006664-ykfvbypo	240	16	but	but	CC
cord-006664-ykfvbypo	240	17	will	will	MD
cord-006664-ykfvbypo	240	18	occur	occur	VB
cord-006664-ykfvbypo	240	19	upon	upon	IN
cord-006664-ykfvbypo	240	20	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	240	21	of	of	IN
cord-006664-ykfvbypo	240	22	these	these	DT
cord-006664-ykfvbypo	240	23	areas	area	NNS
cord-006664-ykfvbypo	240	24	.	.	.
cord-006664-ykfvbypo	241	1	14	14	CD
cord-006664-ykfvbypo	242	1	Therefore	therefore	RB
cord-006664-ykfvbypo	242	2	,	,	,
cord-006664-ykfvbypo	242	3	while	while	IN
cord-006664-ykfvbypo	242	4	one	one	CD
cord-006664-ykfvbypo	242	5	may	may	MD
cord-006664-ykfvbypo	242	6	attempt	attempt	VB
cord-006664-ykfvbypo	242	7	to	to	TO
cord-006664-ykfvbypo	242	8	deal	deal	VB
cord-006664-ykfvbypo	242	9	with	with	IN
cord-006664-ykfvbypo	242	10	an	an	DT
cord-006664-ykfvbypo	242	11	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	242	12	thrombus	thrombus	NN
cord-006664-ykfvbypo	242	13	after	after	IN
cord-006664-ykfvbypo	242	14	the	the	DT
cord-006664-ykfvbypo	242	15	event	event	NN
cord-006664-ykfvbypo	242	16	occurs	occur	VBZ
cord-006664-ykfvbypo	242	17	,	,	,
cord-006664-ykfvbypo	242	18	acute	acute	JJ
cord-006664-ykfvbypo	242	19	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	242	20	cardiomyocyte	cardiomyocyte	NNP
cord-006664-ykfvbypo	242	21	death	death	NN
cord-006664-ykfvbypo	242	22	,	,	,
cord-006664-ykfvbypo	242	23	while	while	IN
cord-006664-ykfvbypo	242	24	it	-PRON-	PRP
cord-006664-ykfvbypo	242	25	may	may	MD
cord-006664-ykfvbypo	242	26	be	be	VB
cord-006664-ykfvbypo	242	27	prompted	prompt	VBN
cord-006664-ykfvbypo	242	28	,	,	,
cord-006664-ykfvbypo	242	29	begins	begin	VBZ
cord-006664-ykfvbypo	242	30	when	when	WRB
cord-006664-ykfvbypo	242	31	flow	flow	NN
cord-006664-ykfvbypo	242	32	is	be	VBZ
cord-006664-ykfvbypo	242	33	partially	partially	RB
cord-006664-ykfvbypo	242	34	or	or	CC
cord-006664-ykfvbypo	242	35	fully	fully	RB
cord-006664-ykfvbypo	242	36	restored	restore	VBN
cord-006664-ykfvbypo	242	37	.	.	.
cord-006664-ykfvbypo	243	1	Therefore	therefore	RB
cord-006664-ykfvbypo	243	2	,	,	,
cord-006664-ykfvbypo	243	3	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	243	4	by	by	IN
cord-006664-ykfvbypo	243	5	recanalisation	recanalisation	NN
cord-006664-ykfvbypo	243	6	,	,	,
cord-006664-ykfvbypo	243	7	thrombolysis	thrombolysis	NN
cord-006664-ykfvbypo	243	8	or	or	CC
cord-006664-ykfvbypo	243	9	angioplasty	angioplasty	NN
cord-006664-ykfvbypo	243	10	provides	provide	VBZ
cord-006664-ykfvbypo	243	11	a	a	DT
cord-006664-ykfvbypo	243	12	window	window	NN
cord-006664-ykfvbypo	243	13	from	from	IN
cord-006664-ykfvbypo	243	14	which	which	WDT
cord-006664-ykfvbypo	243	15	time	time	NN
cord-006664-ykfvbypo	243	16	onwards	onwards	RB
cord-006664-ykfvbypo	243	17	the	the	DT
cord-006664-ykfvbypo	243	18	contribution	contribution	NN
cord-006664-ykfvbypo	243	19	of	of	IN
cord-006664-ykfvbypo	243	20	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	243	21	cell	cell	NN
cord-006664-ykfvbypo	243	22	death	death	NN
cord-006664-ykfvbypo	243	23	to	to	IN
cord-006664-ykfvbypo	243	24	the	the	DT
cord-006664-ykfvbypo	243	25	pathological	pathological	JJ
cord-006664-ykfvbypo	243	26	process	process	NN
cord-006664-ykfvbypo	243	27	is	be	VBZ
cord-006664-ykfvbypo	243	28	potentially	potentially	RB
cord-006664-ykfvbypo	243	29	amenable	amenable	JJ
cord-006664-ykfvbypo	243	30	to	to	IN
cord-006664-ykfvbypo	243	31	attenuation	attenuation	NN
cord-006664-ykfvbypo	243	32	.	.	.
cord-006664-ykfvbypo	244	1	Antioxidants	antioxidant	NNS
cord-006664-ykfvbypo	244	2	and	and	CC
cord-006664-ykfvbypo	244	3	free	free	JJ
cord-006664-ykfvbypo	244	4	radical	radical	JJ
cord-006664-ykfvbypo	244	5	scavengers	scavenger	NNS
cord-006664-ykfvbypo	244	6	such	such	JJ
cord-006664-ykfvbypo	244	7	as	as	IN
cord-006664-ykfvbypo	244	8	superoxide	superoxide	NN
cord-006664-ykfvbypo	244	9	dismutase	dismutase	NN
cord-006664-ykfvbypo	244	10	have	have	VBP
cord-006664-ykfvbypo	244	11	been	be	VBN
cord-006664-ykfvbypo	244	12	used	use	VBN
cord-006664-ykfvbypo	244	13	to	to	TO
cord-006664-ykfvbypo	244	14	counteract	counteract	VB
cord-006664-ykfvbypo	244	15	the	the	DT
cord-006664-ykfvbypo	244	16	pro	pro	JJ
cord-006664-ykfvbypo	244	17	-	-	JJ
cord-006664-ykfvbypo	244	18	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	244	19	effects	effect	NNS
cord-006664-ykfvbypo	244	20	of	of	IN
cord-006664-ykfvbypo	244	21	oxidative	oxidative	JJ
cord-006664-ykfvbypo	244	22	stress	stress	NN
cord-006664-ykfvbypo	244	23	on	on	IN
cord-006664-ykfvbypo	244	24	tissues	tissue	NNS
cord-006664-ykfvbypo	244	25	exposed	expose	VBN
cord-006664-ykfvbypo	244	26	to	to	IN
cord-006664-ykfvbypo	244	27	IR	IR	NNP
cord-006664-ykfvbypo	244	28	.	.	.
cord-006664-ykfvbypo	245	1	1	1	CD
cord-006664-ykfvbypo	245	2	°	°	NN
cord-006664-ykfvbypo	245	3	9	9	CD
cord-006664-ykfvbypo	245	4	,	,	,
cord-006664-ykfvbypo	245	5	"	"	``
cord-006664-ykfvbypo	245	6	Vascular	vascular	JJ
cord-006664-ykfvbypo	245	7	endothelial	endothelial	JJ
cord-006664-ykfvbypo	245	8	cells	cell	NNS
cord-006664-ykfvbypo	245	9	in	in	IN
cord-006664-ykfvbypo	245	10	vitro	vitro	NNS
cord-006664-ykfvbypo	245	11	are	be	VBP
cord-006664-ykfvbypo	245	12	protected	protect	VBN
cord-006664-ykfvbypo	245	13	from	from	IN
cord-006664-ykfvbypo	245	14	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	245	15	cell	cell	NN
cord-006664-ykfvbypo	245	16	death	death	NN
cord-006664-ykfvbypo	245	17	in	in	IN
cord-006664-ykfvbypo	245	18	a	a	DT
cord-006664-ykfvbypo	245	19	SIRS	SIRS	NNP
cord-006664-ykfvbypo	245	20	analogous	analogous	JJ
cord-006664-ykfvbypo	245	21	model	model	NN
cord-006664-ykfvbypo	245	22	using	use	VBG
cord-006664-ykfvbypo	245	23	the	the	DT
cord-006664-ykfvbypo	245	24	amino	amino	NN
cord-006664-ykfvbypo	245	25	acid	acid	NN
cord-006664-ykfvbypo	245	26	taurine	taurine	NN
cord-006664-ykfvbypo	245	27	.	.	.
cord-006664-ykfvbypo	246	1	11	11	CD
cord-006664-ykfvbypo	247	1	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	247	2	in	in	IN
cord-006664-ykfvbypo	247	3	the	the	DT
cord-006664-ykfvbypo	247	4	diseased	diseased	JJ
cord-006664-ykfvbypo	247	5	myocardium	myocardium	NN
cord-006664-ykfvbypo	247	6	Cardiomyocyte	Cardiomyocyte	NNP
cord-006664-ykfvbypo	247	7	cell	cell	NN
cord-006664-ykfvbypo	247	8	loss	loss	NN
cord-006664-ykfvbypo	247	9	and	and	CC
cord-006664-ykfvbypo	247	10	scar	scar	NN
cord-006664-ykfvbypo	247	11	formation	formation	NN
cord-006664-ykfvbypo	247	12	are	be	VBP
cord-006664-ykfvbypo	247	13	integral	integral	JJ
cord-006664-ykfvbypo	247	14	components	component	NNS
cord-006664-ykfvbypo	247	15	of	of	IN
cord-006664-ykfvbypo	247	16	cardiac	cardiac	JJ
cord-006664-ykfvbypo	247	17	dysfunction	dysfunction	NN
cord-006664-ykfvbypo	247	18	from	from	IN
cord-006664-ykfvbypo	247	19	numerous	numerous	JJ
cord-006664-ykfvbypo	247	20	aetiologies	aetiology	NNS
cord-006664-ykfvbypo	247	21	.	.	.
cord-006664-ykfvbypo	248	1	Experimental	experimental	JJ
cord-006664-ykfvbypo	248	2	and	and	CC
cord-006664-ykfvbypo	248	3	autopsy	autopsy	JJ
cord-006664-ykfvbypo	248	4	studies	study	NNS
cord-006664-ykfvbypo	248	5	have	have	VBP
cord-006664-ykfvbypo	248	6	confirmed	confirm	VBN
cord-006664-ykfvbypo	248	7	that	that	IN
cord-006664-ykfvbypo	248	8	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	248	9	undergo	undergo	VBP
cord-006664-ykfvbypo	248	10	cell	cell	NN
cord-006664-ykfvbypo	248	11	death	death	NN
cord-006664-ykfvbypo	248	12	by	by	IN
cord-006664-ykfvbypo	248	13	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	248	14	as	as	IN
cord-006664-ykfvbypo	248	15	a	a	DT
cord-006664-ykfvbypo	248	16	component	component	NN
cord-006664-ykfvbypo	248	17	of	of	IN
cord-006664-ykfvbypo	248	18	hypoxia,43	hypoxia,43	JJ
cord-006664-ykfvbypo	248	19	IR,14	IR,14	``
cord-006664-ykfvbypo	248	20	heart	heart	NN
cord-006664-ykfvbypo	248	21	failure	failure	NN
cord-006664-ykfvbypo	248	22	15	15	CD
cord-006664-ykfvbypo	248	23	,	,	,
cord-006664-ykfvbypo	248	24	16	16	CD
cord-006664-ykfvbypo	248	25	,	,	,
cord-006664-ykfvbypo	248	26	44	44	CD
cord-006664-ykfvbypo	248	27	,	,	,
cord-006664-ykfvbypo	248	28	117	117	CD
cord-006664-ykfvbypo	248	29	,	,	,
cord-006664-ykfvbypo	248	30	119	119	CD
cord-006664-ykfvbypo	248	31	and	and	CC
cord-006664-ykfvbypo	248	32	myocardial	myocardial	JJ
cord-006664-ykfvbypo	248	33	infarction.l$	infarction.l$	NNP
cord-006664-ykfvbypo	248	34	Following	follow	VBG
cord-006664-ykfvbypo	248	35	on	on	RP
cord-006664-ykfvbypo	248	36	from	from	IN
cord-006664-ykfvbypo	248	37	this	this	DT
cord-006664-ykfvbypo	248	38	work	work	NN
cord-006664-ykfvbypo	248	39	,	,	,
cord-006664-ykfvbypo	248	40	the	the	DT
cord-006664-ykfvbypo	248	41	traditional	traditional	JJ
cord-006664-ykfvbypo	248	42	viewpoint	viewpoint	NN
cord-006664-ykfvbypo	248	43	of	of	IN
cord-006664-ykfvbypo	248	44	heart	heart	NN
cord-006664-ykfvbypo	248	45	failure	failure	NN
cord-006664-ykfvbypo	248	46	as	as	IN
cord-006664-ykfvbypo	248	47	a	a	DT
cord-006664-ykfvbypo	248	48	purely	purely	RB
cord-006664-ykfvbypo	248	49	haemodynamic	haemodynamic	JJ
cord-006664-ykfvbypo	248	50	continuum	continuum	NN
cord-006664-ykfvbypo	248	51	has	have	VBZ
cord-006664-ykfvbypo	248	52	been	be	VBN
cord-006664-ykfvbypo	248	53	modified	modify	VBN
cord-006664-ykfvbypo	248	54	by	by	IN
cord-006664-ykfvbypo	248	55	an	an	DT
cord-006664-ykfvbypo	248	56	increasing	increase	VBG
cord-006664-ykfvbypo	248	57	awareness	awareness	NN
cord-006664-ykfvbypo	248	58	of	of	IN
cord-006664-ykfvbypo	248	59	the	the	DT
cord-006664-ykfvbypo	248	60	fact	fact	NN
cord-006664-ykfvbypo	248	61	that	that	IN
cord-006664-ykfvbypo	248	62	the	the	DT
cord-006664-ykfvbypo	248	63	interaction	interaction	NN
cord-006664-ykfvbypo	248	64	of	of	IN
cord-006664-ykfvbypo	248	65	cytokines	cytokine	NNS
cord-006664-ykfvbypo	248	66	,	,	,
cord-006664-ykfvbypo	248	67	neurohormones	neurohormone	NNS
cord-006664-ykfvbypo	248	68	and	and	CC
cord-006664-ykfvbypo	248	69	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	248	70	mediators	mediator	NNS
cord-006664-ykfvbypo	248	71	play	play	VBP
cord-006664-ykfvbypo	248	72	a	a	DT
cord-006664-ykfvbypo	248	73	significant	significant	JJ
cord-006664-ykfvbypo	248	74	role	role	NN
cord-006664-ykfvbypo	248	75	in	in	IN
cord-006664-ykfvbypo	248	76	the	the	DT
cord-006664-ykfvbypo	248	77	evolution	evolution	NN
cord-006664-ykfvbypo	248	78	and	and	CC
cord-006664-ykfvbypo	248	79	progression	progression	NN
cord-006664-ykfvbypo	248	80	of	of	IN
cord-006664-ykfvbypo	248	81	this	this	DT
cord-006664-ykfvbypo	248	82	disease	disease	NN
cord-006664-ykfvbypo	248	83	process	process	NN
cord-006664-ykfvbypo	248	84	.	.	.
cord-006664-ykfvbypo	248	85	"	"	''
cord-006664-ykfvbypo	248	86	°	°	NNS
cord-006664-ykfvbypo	248	87	As	as	IN
cord-006664-ykfvbypo	248	88	the	the	DT
cord-006664-ykfvbypo	248	89	myocardium	myocardium	NN
cord-006664-ykfvbypo	248	90	has	have	VBZ
cord-006664-ykfvbypo	248	91	no	no	DT
cord-006664-ykfvbypo	248	92	regenerative	regenerative	JJ
cord-006664-ykfvbypo	248	93	capacity	capacity	NN
cord-006664-ykfvbypo	248	94	,	,	,
cord-006664-ykfvbypo	248	95	prevention	prevention	NN
cord-006664-ykfvbypo	248	96	of	of	IN
cord-006664-ykfvbypo	248	97	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	248	98	-	-	HYPH
cord-006664-ykfvbypo	248	99	induced	induce	VBN
cord-006664-ykfvbypo	248	100	cardiomyocyte	cardiomyocyte	NNP
cord-006664-ykfvbypo	248	101	loss	loss	NN
cord-006664-ykfvbypo	248	102	has	have	VBZ
cord-006664-ykfvbypo	248	103	potentially	potentially	RB
cord-006664-ykfvbypo	248	104	significant	significant	JJ
cord-006664-ykfvbypo	248	105	clinical	clinical	JJ
cord-006664-ykfvbypo	248	106	implications	implication	NNS
cord-006664-ykfvbypo	248	107	.	.	.
cord-006664-ykfvbypo	249	1	The	the	DT
cord-006664-ykfvbypo	249	2	changes	change	NNS
cord-006664-ykfvbypo	249	3	in	in	IN
cord-006664-ykfvbypo	249	4	myocardial	myocardial	JJ
cord-006664-ykfvbypo	249	5	loading	loading	NN
cord-006664-ykfvbypo	249	6	that	that	WDT
cord-006664-ykfvbypo	249	7	accompany	accompany	VBP
cord-006664-ykfvbypo	249	8	heart	heart	NN
cord-006664-ykfvbypo	249	9	disease	disease	NN
cord-006664-ykfvbypo	249	10	of	of	IN
cord-006664-ykfvbypo	249	11	ischaemic	ischaemic	JJ
cord-006664-ykfvbypo	249	12	or	or	CC
cord-006664-ykfvbypo	249	13	non	non	JJ
cord-006664-ykfvbypo	249	14	-	-	JJ
cord-006664-ykfvbypo	249	15	ischaemic	ischaemic	JJ
cord-006664-ykfvbypo	249	16	origin	origin	NN
cord-006664-ykfvbypo	249	17	activate	activate	VBP
cord-006664-ykfvbypo	249	18	various	various	JJ
cord-006664-ykfvbypo	249	19	cellular	cellular	JJ
cord-006664-ykfvbypo	249	20	responses	response	NNS
cord-006664-ykfvbypo	249	21	.	.	.
cord-006664-ykfvbypo	250	1	Apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	250	2	myocyte	myocyte	NNP
cord-006664-ykfvbypo	251	1	death	death	NN
cord-006664-ykfvbypo	251	2	is	be	VBZ
cord-006664-ykfvbypo	251	3	a	a	DT
cord-006664-ykfvbypo	251	4	sequel	sequel	NN
cord-006664-ykfvbypo	251	5	of	of	IN
cord-006664-ykfvbypo	251	6	such	such	JJ
cord-006664-ykfvbypo	251	7	physical	physical	JJ
cord-006664-ykfvbypo	251	8	stresses	stress	NNS
cord-006664-ykfvbypo	251	9	.	.	.
cord-006664-ykfvbypo	252	1	"	"	``
cord-006664-ykfvbypo	252	2	Animal	animal	NN
cord-006664-ykfvbypo	252	3	studies	study	NNS
cord-006664-ykfvbypo	252	4	of	of	IN
cord-006664-ykfvbypo	252	5	pressure	pressure	NN
cord-006664-ykfvbypo	252	6	overload	overload	NN
cord-006664-ykfvbypo	252	7	hypertrophy	hypertrophy	NN
cord-006664-ykfvbypo	252	8	models	model	NNS
cord-006664-ykfvbypo	252	9	,	,	,
cord-006664-ykfvbypo	252	10	such	such	JJ
cord-006664-ykfvbypo	252	11	as	as	IN
cord-006664-ykfvbypo	252	12	aortic	aortic	JJ
cord-006664-ykfvbypo	252	13	banding	banding	NN
cord-006664-ykfvbypo	252	14	,	,	,
cord-006664-ykfvbypo	252	15	loading	loading	NN
cord-006664-ykfvbypo	252	16	of	of	IN
cord-006664-ykfvbypo	252	17	isolated	isolated	JJ
cord-006664-ykfvbypo	252	18	papillary	papillary	JJ
cord-006664-ykfvbypo	252	19	muscle	muscle	NN
cord-006664-ykfvbypo	252	20	and	and	CC
cord-006664-ykfvbypo	252	21	genetically	genetically	RB
cord-006664-ykfvbypo	252	22	determined	determine	VBN
cord-006664-ykfvbypo	252	23	hypertension	hypertension	NN
cord-006664-ykfvbypo	252	24	,	,	,
cord-006664-ykfvbypo	252	25	have	have	VBP
cord-006664-ykfvbypo	252	26	all	all	DT
cord-006664-ykfvbypo	252	27	demonstrated	demonstrate	VBN
cord-006664-ykfvbypo	252	28	resultant	resultant	JJ
cord-006664-ykfvbypo	252	29	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	252	30	cardiomyocyte	cardiomyocyte	NN
cord-006664-ykfvbypo	252	31	losses	loss	NNS
cord-006664-ykfvbypo	252	32	.	.	.
cord-006664-ykfvbypo	253	1	2,1'2	2,1'2	LS
cord-006664-ykfvbypo	253	2	.	.	.
cord-006664-ykfvbypo	254	1	113	113	CD
cord-006664-ykfvbypo	255	1	The	the	DT
cord-006664-ykfvbypo	255	2	progression	progression	NN
cord-006664-ykfvbypo	255	3	of	of	IN
cord-006664-ykfvbypo	255	4	cardiac	cardiac	JJ
cord-006664-ykfvbypo	255	5	hypertrophy	hypertrophy	NN
cord-006664-ykfvbypo	255	6	resulting	result	VBG
cord-006664-ykfvbypo	255	7	from	from	IN
cord-006664-ykfvbypo	255	8	pressure	pressure	NN
cord-006664-ykfvbypo	255	9	overload	overload	NN
cord-006664-ykfvbypo	255	10	involves	involve	VBZ
cord-006664-ykfvbypo	255	11	myocyte	myocyte	NNP
cord-006664-ykfvbypo	255	12	loss	loss	NN
cord-006664-ykfvbypo	255	13	with	with	IN
cord-006664-ykfvbypo	255	14	hypertrophy	hypertrophy	NN
cord-006664-ykfvbypo	255	15	of	of	IN
cord-006664-ykfvbypo	255	16	the	the	DT
cord-006664-ykfvbypo	255	17	remaining	remain	VBG
cord-006664-ykfvbypo	255	18	myocytes	myocyte	NNS
cord-006664-ykfvbypo	255	19	and	and	CC
cord-006664-ykfvbypo	255	20	proliferation	proliferation	NN
cord-006664-ykfvbypo	255	21	of	of	IN
cord-006664-ykfvbypo	255	22	non	non	JJ
cord-006664-ykfvbypo	255	23	-	-	JJ
cord-006664-ykfvbypo	255	24	muscle	muscle	JJ
cord-006664-ykfvbypo	255	25	cells	cell	NNS
cord-006664-ykfvbypo	255	26	.	.	.
cord-006664-ykfvbypo	256	1	In	in	IN
cord-006664-ykfvbypo	256	2	a	a	DT
cord-006664-ykfvbypo	256	3	rat	rat	NN
cord-006664-ykfvbypo	256	4	model	model	NN
cord-006664-ykfvbypo	256	5	of	of	IN
cord-006664-ykfvbypo	256	6	pressure	pressure	NN
cord-006664-ykfvbypo	256	7	overload	overload	NN
cord-006664-ykfvbypo	256	8	,	,	,
cord-006664-ykfvbypo	256	9	the	the	DT
cord-006664-ykfvbypo	256	10	secondary	secondary	JJ
cord-006664-ykfvbypo	256	11	cardiac	cardiac	JJ
cord-006664-ykfvbypo	256	12	hypertrophy	hypertrophy	NN
cord-006664-ykfvbypo	256	13	and	and	CC
cord-006664-ykfvbypo	256	14	remodelling	remodelling	NN
cord-006664-ykfvbypo	256	15	was	be	VBD
cord-006664-ykfvbypo	256	16	initiated	initiate	VBN
cord-006664-ykfvbypo	256	17	by	by	IN
cord-006664-ykfvbypo	256	18	a	a	DT
cord-006664-ykfvbypo	256	19	wave	wave	NN
cord-006664-ykfvbypo	256	20	of	of	IN
cord-006664-ykfvbypo	256	21	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	256	22	cardiomyocyte	cardiomyocyte	NNP
cord-006664-ykfvbypo	256	23	death	death	NN
cord-006664-ykfvbypo	256	24	,	,	,
cord-006664-ykfvbypo	256	25	thus	thus	RB
cord-006664-ykfvbypo	256	26	implicating	implicate	VBG
cord-006664-ykfvbypo	256	27	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	256	28	in	in	IN
cord-006664-ykfvbypo	256	29	the	the	DT
cord-006664-ykfvbypo	256	30	pathogenesis	pathogenesis	NN
cord-006664-ykfvbypo	256	31	of	of	IN
cord-006664-ykfvbypo	256	32	these	these	DT
cord-006664-ykfvbypo	256	33	events	event	NNS
cord-006664-ykfvbypo	256	34	.	.	.
cord-006664-ykfvbypo	257	1	"	"	''
cord-006664-ykfvbypo	258	1	Leri	Leri	NNP
cord-006664-ykfvbypo	258	2	et	et	FW
cord-006664-ykfvbypo	258	3	al	al	NNP
cord-006664-ykfvbypo	258	4	'	'	''
cord-006664-ykfvbypo	259	1	`	`	''
cord-006664-ykfvbypo	259	2	4	4	CD
cord-006664-ykfvbypo	259	3	have	have	VBP
cord-006664-ykfvbypo	259	4	suggested	suggest	VBN
cord-006664-ykfvbypo	259	5	a	a	DT
cord-006664-ykfvbypo	259	6	mechanism	mechanism	NN
cord-006664-ykfvbypo	259	7	whereby	whereby	WRB
cord-006664-ykfvbypo	259	8	myocyte	myocyte	NNP
cord-006664-ykfvbypo	259	9	stretch	stretch	NN
cord-006664-ykfvbypo	259	10	-	-	HYPH
cord-006664-ykfvbypo	259	11	induced	induce	VBN
cord-006664-ykfvbypo	259	12	autocrine	autocrine	NN
cord-006664-ykfvbypo	259	13	release	release	NN
cord-006664-ykfvbypo	259	14	of	of	IN
cord-006664-ykfvbypo	259	15	angiotensin	angiotensin	NN
cord-006664-ykfvbypo	259	16	II	II	NNP
cord-006664-ykfvbypo	259	17	is	be	VBZ
cord-006664-ykfvbypo	259	18	associated	associate	VBN
cord-006664-ykfvbypo	259	19	with	with	IN
cord-006664-ykfvbypo	259	20	activation	activation	NN
cord-006664-ykfvbypo	259	21	of	of	IN
cord-006664-ykfvbypo	259	22	p53	p53	NN
cord-006664-ykfvbypo	259	23	,	,	,
cord-006664-ykfvbypo	259	24	thus	thus	RB
cord-006664-ykfvbypo	259	25	resulting	result	VBG
cord-006664-ykfvbypo	259	26	in	in	IN
cord-006664-ykfvbypo	259	27	prolonged	prolonged	JJ
cord-006664-ykfvbypo	259	28	upregulation	upregulation	NN
cord-006664-ykfvbypo	259	29	of	of	IN
cord-006664-ykfvbypo	259	30	myocyte	myocyte	NNP
cord-006664-ykfvbypo	259	31	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	259	32	.	.	.
cord-006664-ykfvbypo	260	1	This	this	DT
cord-006664-ykfvbypo	260	2	suggestion	suggestion	NN
cord-006664-ykfvbypo	260	3	was	be	VBD
cord-006664-ykfvbypo	260	4	reinforced	reinforce	VBN
cord-006664-ykfvbypo	260	5	by	by	IN
cord-006664-ykfvbypo	260	6	Kajstura	Kajstura	NNP
cord-006664-ykfvbypo	260	7	et	et	NNP
cord-006664-ykfvbypo	260	8	al	al	NNP
cord-006664-ykfvbypo	260	9	"	"	''
cord-006664-ykfvbypo	260	10	'	'	''
cord-006664-ykfvbypo	260	11	who	who	WP
cord-006664-ykfvbypo	260	12	noted	note	VBD
cord-006664-ykfvbypo	260	13	an	an	DT
cord-006664-ykfvbypo	260	14	increased	increase	VBN
cord-006664-ykfvbypo	260	15	incidence	incidence	NN
cord-006664-ykfvbypo	260	16	of	of	IN
cord-006664-ykfvbypo	260	17	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	260	18	after	after	IN
cord-006664-ykfvbypo	260	19	treatment	treatment	NN
cord-006664-ykfvbypo	260	20	of	of	IN
cord-006664-ykfvbypo	260	21	isolated	isolate	VBN
cord-006664-ykfvbypo	260	22	adult	adult	NN
cord-006664-ykfvbypo	260	23	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	260	24	with	with	IN
cord-006664-ykfvbypo	260	25	angiotensin	angiotensin	NN
cord-006664-ykfvbypo	260	26	II	II	NNP
cord-006664-ykfvbypo	260	27	.	.	.
cord-006664-ykfvbypo	261	1	Furthermore	furthermore	RB
cord-006664-ykfvbypo	261	2	,	,	,
cord-006664-ykfvbypo	261	3	in	in	IN
cord-006664-ykfvbypo	261	4	myocytes	myocyte	NNS
cord-006664-ykfvbypo	261	5	subjected	subject	VBN
cord-006664-ykfvbypo	261	6	to	to	TO
cord-006664-ykfvbypo	261	7	stretch	stretch	VB
cord-006664-ykfvbypo	261	8	,	,	,
cord-006664-ykfvbypo	261	9	the	the	DT
cord-006664-ykfvbypo	261	10	bcl-2	bcl-2	NN
cord-006664-ykfvbypo	261	11	to	to	IN
cord-006664-ykfvbypo	261	12	bax	bax	NNP
cord-006664-ykfvbypo	261	13	ratio	ratio	NN
cord-006664-ykfvbypo	261	14	was	be	VBD
cord-006664-ykfvbypo	261	15	lowered	lower	VBN
cord-006664-ykfvbypo	261	16	,	,	,
cord-006664-ykfvbypo	261	17	thus	thus	RB
cord-006664-ykfvbypo	261	18	increasing	increase	VBG
cord-006664-ykfvbypo	261	19	myocyte	myocyte	NNP
cord-006664-ykfvbypo	261	20	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	261	21	susceptibility	susceptibility	NN
cord-006664-ykfvbypo	261	22	.	.	.
cord-006664-ykfvbypo	262	1	118	118	CD
cord-006664-ykfvbypo	263	1	Thus	thus	RB
cord-006664-ykfvbypo	263	2	,	,	,
cord-006664-ykfvbypo	263	3	the	the	DT
cord-006664-ykfvbypo	263	4	possibility	possibility	NN
cord-006664-ykfvbypo	263	5	arises	arise	VBZ
cord-006664-ykfvbypo	263	6	that	that	IN
cord-006664-ykfvbypo	263	7	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	263	8	may	may	MD
cord-006664-ykfvbypo	263	9	be	be	VB
cord-006664-ykfvbypo	263	10	involved	involve	VBN
cord-006664-ykfvbypo	263	11	in	in	IN
cord-006664-ykfvbypo	263	12	the	the	DT
cord-006664-ykfvbypo	263	13	pathogenesis	pathogenesis	NN
cord-006664-ykfvbypo	263	14	of	of	IN
cord-006664-ykfvbypo	263	15	overall	overall	JJ
cord-006664-ykfvbypo	263	16	cardiac	cardiac	JJ
cord-006664-ykfvbypo	263	17	remodelling	remodelling	NN
cord-006664-ykfvbypo	263	18	.	.	.
cord-006664-ykfvbypo	264	1	13	13	CD
cord-006664-ykfvbypo	264	2	'	'	POS
cord-006664-ykfvbypo	264	3	Postmortem	Postmortem	NNP
cord-006664-ykfvbypo	264	4	examination	examination	NN
cord-006664-ykfvbypo	264	5	studies	study	NNS
cord-006664-ykfvbypo	264	6	of	of	IN
cord-006664-ykfvbypo	264	7	human	human	JJ
cord-006664-ykfvbypo	264	8	hearts	heart	NNS
cord-006664-ykfvbypo	264	9	10	10	CD
cord-006664-ykfvbypo	264	10	days	day	NNS
cord-006664-ykfvbypo	264	11	post	post	JJ
cord-006664-ykfvbypo	264	12	-	-	JJ
cord-006664-ykfvbypo	264	13	myocardial	myocardial	JJ
cord-006664-ykfvbypo	264	14	infarction	infarction	NN
cord-006664-ykfvbypo	264	15	showed	show	VBD
cord-006664-ykfvbypo	264	16	an	an	DT
cord-006664-ykfvbypo	264	17	incidence	incidence	NN
cord-006664-ykfvbypo	264	18	of	of	IN
cord-006664-ykfvbypo	264	19	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	264	20	of	of	IN
cord-006664-ykfvbypo	264	21	0.7	0.7	CD
cord-006664-ykfvbypo	264	22	%	%	NN
cord-006664-ykfvbypo	264	23	in	in	IN
cord-006664-ykfvbypo	264	24	areas	area	NNS
cord-006664-ykfvbypo	264	25	distant	distant	JJ
cord-006664-ykfvbypo	264	26	from	from	IN
cord-006664-ykfvbypo	264	27	the	the	DT
cord-006664-ykfvbypo	264	28	infarct	infarct	NN
cord-006664-ykfvbypo	264	29	.	.	.
cord-006664-ykfvbypo	265	1	There	there	EX
cord-006664-ykfvbypo	265	2	was	be	VBD
cord-006664-ykfvbypo	265	3	no	no	DT
cord-006664-ykfvbypo	265	4	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	265	5	in	in	IN
cord-006664-ykfvbypo	265	6	control	control	NN
cord-006664-ykfvbypo	265	7	non	non	JJ
cord-006664-ykfvbypo	265	8	-	-	JJ
cord-006664-ykfvbypo	265	9	infarcted	infarcted	JJ
cord-006664-ykfvbypo	265	10	hearts.¢	hearts.¢	.
cord-006664-ykfvbypo	266	1	This	this	DT
cord-006664-ykfvbypo	266	2	study	study	NN
cord-006664-ykfvbypo	266	3	implicates	implicate	VBZ
cord-006664-ykfvbypo	266	4	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	266	5	in	in	IN
cord-006664-ykfvbypo	266	6	a	a	DT
cord-006664-ykfvbypo	266	7	wider	wide	JJR
cord-006664-ykfvbypo	266	8	myocardial	myocardial	JJ
cord-006664-ykfvbypo	266	9	role	role	NN
cord-006664-ykfvbypo	266	10	,	,	,
cord-006664-ykfvbypo	266	11	not	not	RB
cord-006664-ykfvbypo	266	12	limited	limited	JJ
cord-006664-ykfvbypo	266	13	to	to	IN
cord-006664-ykfvbypo	266	14	just	just	RB
cord-006664-ykfvbypo	266	15	the	the	DT
cord-006664-ykfvbypo	266	16	infarcted	infarcted	JJ
cord-006664-ykfvbypo	266	17	or	or	CC
cord-006664-ykfvbypo	266	18	hypoxic	hypoxic	JJ
cord-006664-ykfvbypo	266	19	area	area	NN
cord-006664-ykfvbypo	266	20	.	.	.
cord-006664-ykfvbypo	267	1	The	the	DT
cord-006664-ykfvbypo	267	2	ventricular	ventricular	JJ
cord-006664-ykfvbypo	267	3	myocardial	myocardial	JJ
cord-006664-ykfvbypo	267	4	adaptation	adaptation	NN
cord-006664-ykfvbypo	267	5	and	and	CC
cord-006664-ykfvbypo	267	6	remodelling	remodelling	NN
cord-006664-ykfvbypo	267	7	that	that	WDT
cord-006664-ykfvbypo	267	8	occurs	occur	VBZ
cord-006664-ykfvbypo	267	9	in	in	IN
cord-006664-ykfvbypo	267	10	response	response	NN
cord-006664-ykfvbypo	267	11	to	to	IN
cord-006664-ykfvbypo	267	12	pathological	pathological	JJ
cord-006664-ykfvbypo	267	13	stimuli	stimulus	NNS
cord-006664-ykfvbypo	267	14	,	,	,
cord-006664-ykfvbypo	267	15	while	while	IN
cord-006664-ykfvbypo	267	16	it	-PRON-	PRP
cord-006664-ykfvbypo	267	17	may	may	MD
cord-006664-ykfvbypo	267	18	be	be	VB
cord-006664-ykfvbypo	267	19	compensatory	compensatory	JJ
cord-006664-ykfvbypo	267	20	in	in	IN
cord-006664-ykfvbypo	267	21	the	the	DT
cord-006664-ykfvbypo	267	22	short	short	JJ
cord-006664-ykfvbypo	267	23	term	term	NN
cord-006664-ykfvbypo	267	24	,	,	,
cord-006664-ykfvbypo	267	25	may	may	MD
cord-006664-ykfvbypo	267	26	initiate	initiate	VB
cord-006664-ykfvbypo	267	27	changes	change	NNS
cord-006664-ykfvbypo	267	28	leading	lead	VBG
cord-006664-ykfvbypo	267	29	ultimately	ultimately	RB
cord-006664-ykfvbypo	267	30	to	to	TO
cord-006664-ykfvbypo	267	31	pump	pump	VB
cord-006664-ykfvbypo	267	32	failure	failure	NN
cord-006664-ykfvbypo	267	33	.	.	.
cord-006664-ykfvbypo	268	1	Recently	recently	RB
cord-006664-ykfvbypo	268	2	,	,	,
cord-006664-ykfvbypo	268	3	evidence	evidence	NN
cord-006664-ykfvbypo	268	4	has	have	VBZ
cord-006664-ykfvbypo	268	5	been	be	VBN
cord-006664-ykfvbypo	268	6	accumulating	accumulate	VBG
cord-006664-ykfvbypo	268	7	that	that	DT
cord-006664-ykfvbypo	268	8	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	268	9	cellular	cellular	JJ
cord-006664-ykfvbypo	268	10	deletion	deletion	NN
cord-006664-ykfvbypo	268	11	participates	participate	VBZ
cord-006664-ykfvbypo	268	12	,	,	,
cord-006664-ykfvbypo	268	13	and	and	CC
cord-006664-ykfvbypo	268	14	may	may	MD
cord-006664-ykfvbypo	268	15	be	be	VB
cord-006664-ykfvbypo	268	16	a	a	DT
cord-006664-ykfvbypo	268	17	significant	significant	JJ
cord-006664-ykfvbypo	268	18	determinant	determinant	NN
cord-006664-ykfvbypo	268	19	,	,	,
cord-006664-ykfvbypo	268	20	in	in	IN
cord-006664-ykfvbypo	268	21	this	this	DT
cord-006664-ykfvbypo	268	22	pathological	pathological	JJ
cord-006664-ykfvbypo	268	23	transition	transition	NN
cord-006664-ykfvbypo	268	24	process	process	NN
cord-006664-ykfvbypo	268	25	.	.	.
cord-006664-ykfvbypo	268	26	'	'	''
cord-006664-ykfvbypo	269	1	5	5	LS
cord-006664-ykfvbypo	269	2	'	'	CD
cord-006664-ykfvbypo	269	3	6	6	CD
cord-006664-ykfvbypo	269	4	•	•	NNS
cord-006664-ykfvbypo	269	5	13	13	CD
cord-006664-ykfvbypo	269	6	'	'	''
cord-006664-ykfvbypo	269	7	If	if	IN
cord-006664-ykfvbypo	269	8	this	this	DT
cord-006664-ykfvbypo	269	9	rationale	rationale	NN
cord-006664-ykfvbypo	269	10	holds	hold	VBZ
cord-006664-ykfvbypo	269	11	true	true	JJ
cord-006664-ykfvbypo	269	12	,	,	,
cord-006664-ykfvbypo	269	13	then	then	RB
cord-006664-ykfvbypo	269	14	the	the	DT
cord-006664-ykfvbypo	269	15	gradual	gradual	JJ
cord-006664-ykfvbypo	269	16	progression	progression	NN
cord-006664-ykfvbypo	269	17	of	of	IN
cord-006664-ykfvbypo	269	18	myocardial	myocardial	JJ
cord-006664-ykfvbypo	269	19	dysfunction	dysfunction	NN
cord-006664-ykfvbypo	269	20	and	and	CC
cord-006664-ykfvbypo	269	21	ultimate	ultimate	JJ
cord-006664-ykfvbypo	269	22	failure	failure	NN
cord-006664-ykfvbypo	269	23	could	could	MD
cord-006664-ykfvbypo	269	24	potentially	potentially	RB
cord-006664-ykfvbypo	269	25	be	be	VB
cord-006664-ykfvbypo	269	26	halted	halt	VBN
cord-006664-ykfvbypo	269	27	by	by	IN
cord-006664-ykfvbypo	269	28	the	the	DT
cord-006664-ykfvbypo	269	29	arrest	arrest	NN
cord-006664-ykfvbypo	269	30	of	of	IN
cord-006664-ykfvbypo	269	31	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	269	32	in	in	IN
cord-006664-ykfvbypo	269	33	the	the	DT
cord-006664-ykfvbypo	269	34	myocardium	myocardium	NN
cord-006664-ykfvbypo	269	35	.	.	.
cord-006664-ykfvbypo	270	1	The	the	DT
cord-006664-ykfvbypo	270	2	range	range	NN
cord-006664-ykfvbypo	270	3	of	of	IN
cord-006664-ykfvbypo	270	4	cardiac	cardiac	JJ
cord-006664-ykfvbypo	270	5	diseases	disease	NNS
cord-006664-ykfvbypo	270	6	in	in	IN
cord-006664-ykfvbypo	270	7	which	which	WDT
cord-006664-ykfvbypo	270	8	inappropriate	inappropriate	JJ
cord-006664-ykfvbypo	270	9	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	270	10	has	have	VBZ
cord-006664-ykfvbypo	270	11	been	be	VBN
cord-006664-ykfvbypo	270	12	demonstrated	demonstrate	VBN
cord-006664-ykfvbypo	270	13	also	also	RB
cord-006664-ykfvbypo	270	14	includes	include	VBZ
cord-006664-ykfvbypo	270	15	cardiomyopathic	cardiomyopathic	JJ
cord-006664-ykfvbypo	270	16	failure	failure	NN
cord-006664-ykfvbypo	270	17	of	of	IN
cord-006664-ykfvbypo	270	18	ischaemic	ischaemic	JJ
cord-006664-ykfvbypo	270	19	,	,	,
cord-006664-ykfvbypo	270	20	viral	viral	JJ
cord-006664-ykfvbypo	270	21	and	and	CC
cord-006664-ykfvbypo	270	22	idiopathic	idiopathic	JJ
cord-006664-ykfvbypo	270	23	origin	origin	NN
cord-006664-ykfvbypo	270	24	,	,	,
cord-006664-ykfvbypo	270	25	as	as	RB
cord-006664-ykfvbypo	270	26	well	well	RB
cord-006664-ykfvbypo	270	27	as	as	IN
cord-006664-ykfvbypo	270	28	in	in	IN
cord-006664-ykfvbypo	270	29	arrhythmogenic	arrhythmogenic	NNP
cord-006664-ykfvbypo	270	30	right	right	JJ
cord-006664-ykfvbypo	270	31	ventricular	ventricular	JJ
cord-006664-ykfvbypo	270	32	dysplasia	dysplasia	NN
cord-006664-ykfvbypo	270	33	.	.	.
cord-006664-ykfvbypo	271	1	'	'	``
cord-006664-ykfvbypo	271	2	5	5	CD
cord-006664-ykfvbypo	271	3	'	'	''
cord-006664-ykfvbypo	271	4	"	"	''
cord-006664-ykfvbypo	271	5	49	49	CD
cord-006664-ykfvbypo	271	6	.	.	.
cord-006664-ykfvbypo	272	1	"	"	``
cord-006664-ykfvbypo	272	2	6	6	CD
cord-006664-ykfvbypo	273	1	In	in	IN
cord-006664-ykfvbypo	273	2	myocardial	myocardial	JJ
cord-006664-ykfvbypo	273	3	ischaemia	ischaemia	NN
cord-006664-ykfvbypo	273	4	,	,	,
cord-006664-ykfvbypo	273	5	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	273	6	rather	rather	RB
cord-006664-ykfvbypo	273	7	than	than	IN
cord-006664-ykfvbypo	273	8	necrosis	necrosis	NN
cord-006664-ykfvbypo	273	9	has	have	VBZ
cord-006664-ykfvbypo	273	10	been	be	VBN
cord-006664-ykfvbypo	273	11	shown	show	VBN
cord-006664-ykfvbypo	273	12	to	to	TO
cord-006664-ykfvbypo	273	13	be	be	VB
cord-006664-ykfvbypo	273	14	the	the	DT
cord-006664-ykfvbypo	273	15	critical	critical	JJ
cord-006664-ykfvbypo	273	16	determinant	determinant	NN
cord-006664-ykfvbypo	273	17	of	of	IN
cord-006664-ykfvbypo	273	18	eventual	eventual	JJ
cord-006664-ykfvbypo	273	19	myocardial	myocardial	JJ
cord-006664-ykfvbypo	273	20	infarct	infarct	NN
cord-006664-ykfvbypo	273	21	size	size	NN
cord-006664-ykfvbypo	273	22	and	and	CC
cord-006664-ykfvbypo	273	23	impact	impact	NN
cord-006664-ykfvbypo	273	24	.	.	.
cord-006664-ykfvbypo	274	1	`	`	''
cord-006664-ykfvbypo	274	2	°	°	NNP
cord-006664-ykfvbypo	274	3	,	,	,
cord-006664-ykfvbypo	274	4	44	44	CD
cord-006664-ykfvbypo	275	1	In	in	IN
cord-006664-ykfvbypo	275	2	addition	addition	NN
cord-006664-ykfvbypo	275	3	,	,	,
cord-006664-ykfvbypo	275	4	when	when	WRB
cord-006664-ykfvbypo	275	5	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	275	6	of	of	IN
cord-006664-ykfvbypo	275	7	the	the	DT
cord-006664-ykfvbypo	275	8	myocardium	myocardium	NN
cord-006664-ykfvbypo	275	9	occurs	occur	VBZ
cord-006664-ykfvbypo	275	10	this	this	DT
cord-006664-ykfvbypo	275	11	prompts	prompt	VBZ
cord-006664-ykfvbypo	275	12	a	a	DT
cord-006664-ykfvbypo	275	13	wave	wave	NN
cord-006664-ykfvbypo	275	14	of	of	IN
cord-006664-ykfvbypo	275	15	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	275	16	cell	cell	NN
cord-006664-ykfvbypo	275	17	death	death	NN
cord-006664-ykfvbypo	275	18	,	,	,
cord-006664-ykfvbypo	275	19	aggravating	aggravate	VBG
cord-006664-ykfvbypo	275	20	the	the	DT
cord-006664-ykfvbypo	275	21	ischaemic	ischaemic	JJ
cord-006664-ykfvbypo	275	22	insult	insult	NN
cord-006664-ykfvbypo	275	23	.	.	.
cord-006664-ykfvbypo	276	1	`	`	''
cord-006664-ykfvbypo	276	2	4	4	CD
cord-006664-ykfvbypo	276	3	In	in	IN
cord-006664-ykfvbypo	276	4	vitro	vitro	FW
cord-006664-ykfvbypo	276	5	studies	study	NNS
cord-006664-ykfvbypo	276	6	have	have	VBP
cord-006664-ykfvbypo	276	7	shown	show	VBN
cord-006664-ykfvbypo	276	8	that	that	IN
cord-006664-ykfvbypo	276	9	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	276	10	are	be	VBP
cord-006664-ykfvbypo	276	11	primed	prime	VBN
cord-006664-ykfvbypo	276	12	for	for	IN
cord-006664-ykfvbypo	276	13	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	276	14	,	,	,
cord-006664-ykfvbypo	276	15	which	which	WDT
cord-006664-ykfvbypo	276	16	may	may	MD
cord-006664-ykfvbypo	276	17	be	be	VB
cord-006664-ykfvbypo	276	18	triggered	trigger	VBN
cord-006664-ykfvbypo	276	19	by	by	IN
cord-006664-ykfvbypo	276	20	cytokines	cytokine	NNS
cord-006664-ykfvbypo	276	21	such	such	JJ
cord-006664-ykfvbypo	276	22	as	as	IN
cord-006664-ykfvbypo	276	23	TNFa.23	TNFa.23	NNP
cord-006664-ykfvbypo	276	24	TNFa	TNFa	NNP
cord-006664-ykfvbypo	276	25	is	be	VBZ
cord-006664-ykfvbypo	276	26	a	a	DT
cord-006664-ykfvbypo	276	27	particularly	particularly	RB
cord-006664-ykfvbypo	276	28	clinically	clinically	RB
cord-006664-ykfvbypo	276	29	relevant	relevant	JJ
cord-006664-ykfvbypo	276	30	cytokine	cytokine	NN
cord-006664-ykfvbypo	276	31	,	,	,
cord-006664-ykfvbypo	276	32	being	be	VBG
cord-006664-ykfvbypo	276	33	present	present	JJ
cord-006664-ykfvbypo	276	34	during	during	IN
cord-006664-ykfvbypo	276	35	local	local	JJ
cord-006664-ykfvbypo	276	36	and	and	CC
cord-006664-ykfvbypo	276	37	systemic	systemic	JJ
cord-006664-ykfvbypo	276	38	IR	IR	NNP
cord-006664-ykfvbypo	276	39	,	,	,
cord-006664-ykfvbypo	276	40	sepsis	sepsis	NN
cord-006664-ykfvbypo	276	41	and	and	CC
cord-006664-ykfvbypo	276	42	SIRS	sirs	NN
cord-006664-ykfvbypo	276	43	.	.	.
cord-006664-ykfvbypo	277	1	Chronic	chronic	JJ
cord-006664-ykfvbypo	277	2	infusion	infusion	NN
cord-006664-ykfvbypo	277	3	of	of	IN
cord-006664-ykfvbypo	277	4	TNFa	TNFa	NNS
cord-006664-ykfvbypo	277	5	in	in	IN
cord-006664-ykfvbypo	277	6	vivo	vivo	NNP
cord-006664-ykfvbypo	277	7	has	have	VBZ
cord-006664-ykfvbypo	277	8	been	be	VBN
cord-006664-ykfvbypo	277	9	reported	report	VBN
cord-006664-ykfvbypo	277	10	to	to	TO
cord-006664-ykfvbypo	277	11	cause	cause	VB
cord-006664-ykfvbypo	277	12	rapid	rapid	JJ
cord-006664-ykfvbypo	277	13	onset	onset	NN
cord-006664-ykfvbypo	277	14	of	of	IN
cord-006664-ykfvbypo	277	15	dilated	dilated	JJ
cord-006664-ykfvbypo	277	16	cardiomyopathy	cardiomyopathy	NN
cord-006664-ykfvbypo	277	17	with	with	IN
cord-006664-ykfvbypo	277	18	widespread	widespread	JJ
cord-006664-ykfvbypo	277	19	myocyte	myocyte	NNP
cord-006664-ykfvbypo	277	20	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	277	21	.	.	.
cord-006664-ykfvbypo	278	1	18	18	CD
cord-006664-ykfvbypo	278	2	TNFa	TNFa	NNS
cord-006664-ykfvbypo	278	3	levels	level	NNS
cord-006664-ykfvbypo	278	4	are	be	VBP
cord-006664-ykfvbypo	278	5	elevated	elevate	VBN
cord-006664-ykfvbypo	278	6	in	in	IN
cord-006664-ykfvbypo	278	7	heart	heart	NN
cord-006664-ykfvbypo	278	8	failure	failure	NN
cord-006664-ykfvbypo	278	9	,	,	,
cord-006664-ykfvbypo	278	10	as	as	RB
cord-006664-ykfvbypo	278	11	well	well	RB
cord-006664-ykfvbypo	278	12	as	as	IN
cord-006664-ykfvbypo	278	13	in	in	IN
cord-006664-ykfvbypo	278	14	reperfused	reperfused	JJ
cord-006664-ykfvbypo	278	15	and	and	CC
cord-006664-ykfvbypo	278	16	infarcted	infarcted	JJ
cord-006664-ykfvbypo	278	17	myocardium	myocardium	NN
cord-006664-ykfvbypo	278	18	.	.	.
cord-006664-ykfvbypo	278	19	"	"	''
cord-006664-ykfvbypo	278	20	'	'	''
cord-006664-ykfvbypo	278	21	-	-	:
cord-006664-ykfvbypo	278	22	"	"	''
cord-006664-ykfvbypo	278	23	'	'	''
cord-006664-ykfvbypo	278	24	The	the	DT
cord-006664-ykfvbypo	278	25	finding	finding	NN
cord-006664-ykfvbypo	278	26	that	that	IN
cord-006664-ykfvbypo	278	27	oxidative	oxidative	JJ
cord-006664-ykfvbypo	278	28	stress	stress	NN
cord-006664-ykfvbypo	278	29	induced	induce	VBN
cord-006664-ykfvbypo	278	30	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	278	31	in	in	IN
cord-006664-ykfvbypo	278	32	isolated	isolated	JJ
cord-006664-ykfvbypo	278	33	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	278	34	is	be	VBZ
cord-006664-ykfvbypo	278	35	significant	significant	JJ
cord-006664-ykfvbypo	278	36	as	as	IN
cord-006664-ykfvbypo	278	37	it	-PRON-	PRP
cord-006664-ykfvbypo	278	38	suggests	suggest	VBZ
cord-006664-ykfvbypo	278	39	a	a	DT
cord-006664-ykfvbypo	278	40	direct	direct	JJ
cord-006664-ykfvbypo	278	41	mechanism	mechanism	NN
cord-006664-ykfvbypo	278	42	whereby	whereby	WRB
cord-006664-ykfvbypo	278	43	IR	IR	NNP
cord-006664-ykfvbypo	278	44	can	can	MD
cord-006664-ykfvbypo	278	45	induce	induce	VB
cord-006664-ykfvbypo	278	46	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	278	47	.	.	.
cord-006664-ykfvbypo	279	1	121	121	CD
cord-006664-ykfvbypo	279	2	,	,	,
cord-006664-ykfvbypo	279	3	12	12	CD
cord-006664-ykfvbypo	279	4	'	'	''
cord-006664-ykfvbypo	280	1	Therefore	therefore	RB
cord-006664-ykfvbypo	280	2	,	,	,
cord-006664-ykfvbypo	280	3	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	280	4	are	be	VBP
cord-006664-ykfvbypo	280	5	primed	prime	VBN
cord-006664-ykfvbypo	280	6	for	for	IN
cord-006664-ykfvbypo	280	7	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	280	8	which	which	WDT
cord-006664-ykfvbypo	280	9	may	may	MD
cord-006664-ykfvbypo	280	10	be	be	VB
cord-006664-ykfvbypo	280	11	triggered	trigger	VBN
cord-006664-ykfvbypo	280	12	by	by	IN
cord-006664-ykfvbypo	280	13	cytokines	cytokine	NNS
cord-006664-ykfvbypo	280	14	,	,	,
cord-006664-ykfvbypo	280	15	mechanical	mechanical	JJ
cord-006664-ykfvbypo	280	16	stretch	stretch	NN
cord-006664-ykfvbypo	280	17	or	or	CC
cord-006664-ykfvbypo	280	18	IR	IR	NNP
cord-006664-ykfvbypo	280	19	.	.	.
cord-006664-ykfvbypo	281	1	Interestingly	interestingly	RB
cord-006664-ykfvbypo	281	2	,	,	,
cord-006664-ykfvbypo	281	3	it	-PRON-	PRP
cord-006664-ykfvbypo	281	4	has	have	VBZ
cord-006664-ykfvbypo	281	5	been	be	VBN
cord-006664-ykfvbypo	281	6	suggested	suggest	VBN
cord-006664-ykfvbypo	281	7	that	that	IN
cord-006664-ykfvbypo	281	8	the	the	DT
cord-006664-ykfvbypo	281	9	readiness	readiness	NN
cord-006664-ykfvbypo	281	10	with	with	IN
cord-006664-ykfvbypo	281	11	which	which	WDT
cord-006664-ykfvbypo	281	12	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	281	13	undergo	undergo	VBP
cord-006664-ykfvbypo	281	14	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	281	15	may	may	MD
cord-006664-ykfvbypo	281	16	also	also	RB
cord-006664-ykfvbypo	281	17	explain	explain	VB
cord-006664-ykfvbypo	281	18	the	the	DT
cord-006664-ykfvbypo	281	19	rare	rare	JJ
cord-006664-ykfvbypo	281	20	incidence	incidence	NN
cord-006664-ykfvbypo	281	21	of	of	IN
cord-006664-ykfvbypo	281	22	primary	primary	JJ
cord-006664-ykfvbypo	281	23	cardiac	cardiac	JJ
cord-006664-ykfvbypo	281	24	tumours	tumour	NNS
cord-006664-ykfvbypo	281	25	.	.	.
cord-006664-ykfvbypo	282	1	Investigators	investigator	NNS
cord-006664-ykfvbypo	282	2	attempting	attempt	VBG
cord-006664-ykfvbypo	282	3	to	to	TO
cord-006664-ykfvbypo	282	4	promote	promote	VB
cord-006664-ykfvbypo	282	5	cellular	cellular	JJ
cord-006664-ykfvbypo	282	6	regeneration	regeneration	NN
cord-006664-ykfvbypo	282	7	in	in	IN
cord-006664-ykfvbypo	282	8	the	the	DT
cord-006664-ykfvbypo	282	9	myocardium	myocardium	NN
cord-006664-ykfvbypo	282	10	have	have	VBP
cord-006664-ykfvbypo	282	11	used	use	VBN
cord-006664-ykfvbypo	282	12	recombinant	recombinant	JJ
cord-006664-ykfvbypo	282	13	adenoviruses	adenovirus	NNS
cord-006664-ykfvbypo	282	14	,	,	,
cord-006664-ykfvbypo	282	15	delivering	deliver	VBG
cord-006664-ykfvbypo	282	16	the	the	DT
cord-006664-ykfvbypo	282	17	adenoviral	adenoviral	NNP
cord-006664-ykfvbypo	282	18	protein	protein	NN
cord-006664-ykfvbypo	282	19	12S	12S	NNP
cord-006664-ykfvbypo	282	20	E1A	E1A	NNP
cord-006664-ykfvbypo	282	21	,	,	,
cord-006664-ykfvbypo	282	22	and	and	CC
cord-006664-ykfvbypo	282	23	have	have	VBP
cord-006664-ykfvbypo	282	24	induced	induce	VBN
cord-006664-ykfvbypo	282	25	DNA	dna	NN
cord-006664-ykfvbypo	282	26	synthesis	synthesis	NN
cord-006664-ykfvbypo	282	27	in	in	IN
cord-006664-ykfvbypo	282	28	terminally	terminally	RB
cord-006664-ykfvbypo	282	29	differentiated	differentiate	VBN
cord-006664-ykfvbypo	282	30	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	282	31	.	.	.
cord-006664-ykfvbypo	283	1	91	91	CD
cord-006664-ykfvbypo	284	1	However	however	RB
cord-006664-ykfvbypo	284	2	,	,	,
cord-006664-ykfvbypo	284	3	this	this	DT
cord-006664-ykfvbypo	284	4	was	be	VBD
cord-006664-ykfvbypo	284	5	followed	follow	VBN
cord-006664-ykfvbypo	284	6	by	by	IN
cord-006664-ykfvbypo	284	7	widespread	widespread	JJ
cord-006664-ykfvbypo	284	8	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	284	9	in	in	IN
cord-006664-ykfvbypo	284	10	the	the	DT
cord-006664-ykfvbypo	284	11	absence	absence	NN
cord-006664-ykfvbypo	284	12	of	of	IN
cord-006664-ykfvbypo	284	13	a	a	DT
cord-006664-ykfvbypo	284	14	second	second	JJ
cord-006664-ykfvbypo	284	15	adenoviral	adenoviral	JJ
cord-006664-ykfvbypo	284	16	protein	protein	NN
cord-006664-ykfvbypo	284	17	E	e	NN
cord-006664-ykfvbypo	284	18	1	1	CD
cord-006664-ykfvbypo	284	19	B	B	NNP
cord-006664-ykfvbypo	284	20	,	,	,
cord-006664-ykfvbypo	284	21	a	a	DT
cord-006664-ykfvbypo	284	22	structural	structural	JJ
cord-006664-ykfvbypo	284	23	and	and	CC
cord-006664-ykfvbypo	284	24	functional	functional	JJ
cord-006664-ykfvbypo	284	25	homologue	homologue	NN
cord-006664-ykfvbypo	284	26	of	of	IN
cord-006664-ykfvbypo	284	27	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	284	28	.	.	.
cord-006664-ykfvbypo	285	1	92	92	CD
cord-006664-ykfvbypo	285	2	Introduction	introduction	NN
cord-006664-ykfvbypo	285	3	of	of	IN
cord-006664-ykfvbypo	285	4	the	the	DT
cord-006664-ykfvbypo	285	5	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	285	6	homologue	homologue	NN
cord-006664-ykfvbypo	285	7	allowed	allow	VBD
cord-006664-ykfvbypo	285	8	cardiomyocvte	cardiomyocvte	NN
cord-006664-ykfvbypo	285	9	proliferation	proliferation	NN
cord-006664-ykfvbypo	285	10	and	and	CC
cord-006664-ykfvbypo	285	11	suppressed	suppress	VBN
cord-006664-ykfvbypo	285	12	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	285	13	cell	cell	NN
cord-006664-ykfvbypo	285	14	death	death	NN
cord-006664-ykfvbypo	285	15	.	.	.
cord-006664-ykfvbypo	286	1	The	the	DT
cord-006664-ykfvbypo	286	2	interaction	interaction	NN
cord-006664-ykfvbypo	286	3	of	of	IN
cord-006664-ykfvbypo	286	4	TNFa	TNFa	NNS
cord-006664-ykfvbypo	286	5	with	with	IN
cord-006664-ykfvbypo	286	6	CD95/	CD95/	.
cord-006664-ykfvbypo	287	1	Apol	Apol	NNP
cord-006664-ykfvbypo	287	2	/	/	SYM
cord-006664-ykfvbypo	287	3	Fas	Fas	NNP
cord-006664-ykfvbypo	287	4	is	be	VBZ
cord-006664-ykfvbypo	287	5	directly	directly	RB
cord-006664-ykfvbypo	287	6	implicated	implicate	VBN
cord-006664-ykfvbypo	287	7	in	in	IN
cord-006664-ykfvbypo	287	8	the	the	DT
cord-006664-ykfvbypo	287	9	death	death	NN
cord-006664-ykfvbypo	287	10	of	of	IN
cord-006664-ykfvbypo	287	11	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	287	12	post	post	NN
cord-006664-ykfvbypo	287	13	JR	JR	NNP
cord-006664-ykfvbypo	287	14	.	.	.
cord-006664-ykfvbypo	287	15	'	'	''
cord-006664-ykfvbypo	288	1	66	66	CD
cord-006664-ykfvbypo	289	1	The	the	DT
cord-006664-ykfvbypo	289	2	evidence	evidence	NN
cord-006664-ykfvbypo	289	3	above	above	RB
cord-006664-ykfvbypo	289	4	suggests	suggest	VBZ
cord-006664-ykfvbypo	289	5	that	that	IN
cord-006664-ykfvbypo	289	6	the	the	DT
cord-006664-ykfvbypo	289	7	expression	expression	NN
cord-006664-ykfvbypo	289	8	of	of	IN
cord-006664-ykfvbypo	289	9	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	289	10	in	in	IN
cord-006664-ykfvbypo	289	11	the	the	DT
cord-006664-ykfvbypo	289	12	myocardium	myocardium	NN
cord-006664-ykfvbypo	289	13	is	be	VBZ
cord-006664-ykfvbypo	289	14	a	a	DT
cord-006664-ykfvbypo	289	15	frequent	frequent	JJ
cord-006664-ykfvbypo	289	16	pathological	pathological	JJ
cord-006664-ykfvbypo	289	17	event	event	NN
cord-006664-ykfvbypo	289	18	with	with	IN
cord-006664-ykfvbypo	289	19	significant	significant	JJ
cord-006664-ykfvbypo	289	20	clinical	clinical	JJ
cord-006664-ykfvbypo	289	21	implications	implication	NNS
cord-006664-ykfvbypo	289	22	.	.	.
cord-006664-ykfvbypo	290	1	Atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	290	2	plaque	plaque	NN
cord-006664-ykfvbypo	290	3	destabilisation	destabilisation	NN
cord-006664-ykfvbypo	290	4	has	have	VBZ
cord-006664-ykfvbypo	290	5	been	be	VBN
cord-006664-ykfvbypo	290	6	shown	show	VBN
cord-006664-ykfvbypo	290	7	to	to	TO
cord-006664-ykfvbypo	290	8	be	be	VB
cord-006664-ykfvbypo	290	9	associated	associate	VBN
cord-006664-ykfvbypo	290	10	with	with	IN
cord-006664-ykfvbypo	290	11	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	290	12	cell	cell	NN
cord-006664-ykfvbypo	290	13	death	death	NN
cord-006664-ykfvbypo	290	14	,	,	,
cord-006664-ykfvbypo	290	15	principally	principally	RB
cord-006664-ykfvbypo	290	16	of	of	IN
cord-006664-ykfvbypo	290	17	inflammatory	inflammatory	JJ
cord-006664-ykfvbypo	290	18	cells	cell	NNS
cord-006664-ykfvbypo	290	19	and	and	CC
cord-006664-ykfvbypo	290	20	subendothelial	subendothelial	JJ
cord-006664-ykfvbypo	290	21	smooth	smooth	JJ
cord-006664-ykfvbypo	290	22	muscle	muscle	NN
cord-006664-ykfvbypo	290	23	cells	cell	NNS
cord-006664-ykfvbypo	290	24	in	in	IN
cord-006664-ykfvbypo	290	25	the	the	DT
cord-006664-ykfvbypo	290	26	fibrous	fibrous	JJ
cord-006664-ykfvbypo	290	27	cap	cap	NN
cord-006664-ykfvbypo	290	28	.	.	.
cord-006664-ykfvbypo	291	1	'	'	``
cord-006664-ykfvbypo	291	2	9	9	CD
cord-006664-ykfvbypo	291	3	-	-	SYM
cord-006664-ykfvbypo	291	4	10122	10122	CD
cord-006664-ykfvbypo	291	5	Bennett	Bennett	NNP
cord-006664-ykfvbypo	291	6	et	et	NNP
cord-006664-ykfvbypo	291	7	al12	al12	NNP
cord-006664-ykfvbypo	291	8	'	'	''
cord-006664-ykfvbypo	291	9	have	have	VBP
cord-006664-ykfvbypo	291	10	shown	show	VBN
cord-006664-ykfvbypo	291	11	that	that	IN
cord-006664-ykfvbypo	291	12	human	human	JJ
cord-006664-ykfvbypo	291	13	vascular	vascular	JJ
cord-006664-ykfvbypo	291	14	smooth	smooth	JJ
cord-006664-ykfvbypo	291	15	muscle	muscle	NN
cord-006664-ykfvbypo	291	16	cells	cell	NNS
cord-006664-ykfvbypo	291	17	derived	derive	VBN
cord-006664-ykfvbypo	291	18	from	from	IN
cord-006664-ykfvbypo	291	19	normal	normal	JJ
cord-006664-ykfvbypo	291	20	and	and	CC
cord-006664-ykfvbypo	291	21	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	291	22	endothelium	endothelium	NN
cord-006664-ykfvbypo	291	23	have	have	VBP
cord-006664-ykfvbypo	291	24	different	different	JJ
cord-006664-ykfvbypo	291	25	thresholds	threshold	NNS
cord-006664-ykfvbypo	291	26	for	for	IN
cord-006664-ykfvbypo	291	27	expression	expression	NN
cord-006664-ykfvbypo	291	28	of	of	IN
cord-006664-ykfvbypo	291	29	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	291	30	in	in	IN
cord-006664-ykfvbypo	291	31	vitro	vitro	FW
cord-006664-ykfvbypo	291	32	.	.	.
cord-006664-ykfvbypo	292	1	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	292	2	in	in	IN
cord-006664-ykfvbypo	292	3	normal	normal	JJ
cord-006664-ykfvbypo	292	4	vascular	vascular	JJ
cord-006664-ykfvbypo	292	5	endothelial	endothelial	JJ
cord-006664-ykfvbypo	292	6	smooth	smooth	JJ
cord-006664-ykfvbypo	292	7	muscle	muscle	NN
cord-006664-ykfvbypo	292	8	cells	cell	NNS
cord-006664-ykfvbypo	292	9	occurred	occur	VBD
cord-006664-ykfvbypo	292	10	only	only	RB
cord-006664-ykfvbypo	292	11	on	on	IN
cord-006664-ykfvbypo	292	12	removal	removal	NN
cord-006664-ykfvbypo	292	13	of	of	IN
cord-006664-ykfvbypo	292	14	serum	serum	NN
cord-006664-ykfvbypo	292	15	growth	growth	NN
cord-006664-ykfvbypo	292	16	factors	factor	NNS
cord-006664-ykfvbypo	292	17	.	.	.
cord-006664-ykfvbypo	293	1	However	however	RB
cord-006664-ykfvbypo	293	2	,	,	,
cord-006664-ykfvbypo	293	3	cells	cell	NNS
cord-006664-ykfvbypo	293	4	from	from	IN
cord-006664-ykfvbypo	293	5	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	293	6	plaques	plaque	NNS
cord-006664-ykfvbypo	293	7	died	die	VBD
cord-006664-ykfvbypo	293	8	even	even	RB
cord-006664-ykfvbypo	293	9	with	with	IN
cord-006664-ykfvbypo	293	10	high	high	JJ
cord-006664-ykfvbypo	293	11	serum	serum	NN
cord-006664-ykfvbypo	293	12	conditions	condition	NNS
cord-006664-ykfvbypo	293	13	.	.	.
cord-006664-ykfvbypo	294	1	In	in	IN
cord-006664-ykfvbypo	294	2	addition	addition	NN
cord-006664-ykfvbypo	294	3	,	,	,
cord-006664-ykfvbypo	294	4	bcl-2	bcl-2	NN
cord-006664-ykfvbypo	294	5	expression	expression	NN
cord-006664-ykfvbypo	294	6	induced	induce	VBN
cord-006664-ykfvbypo	294	7	by	by	IN
cord-006664-ykfvbypo	294	8	gene	gene	NN
cord-006664-ykfvbypo	294	9	transfer	transfer	NN
cord-006664-ykfvbypo	294	10	and	and	CC
cord-006664-ykfvbypo	294	11	the	the	DT
cord-006664-ykfvbypo	294	12	cytokines	cytokine	NNS
cord-006664-ykfvbypo	294	13	IGF	IGF	NNP
cord-006664-ykfvbypo	294	14	and	and	CC
cord-006664-ykfvbypo	294	15	PDGF	PDGF	NNP
cord-006664-ykfvbypo	294	16	protected	protect	VBD
cord-006664-ykfvbypo	294	17	against	against	IN
cord-006664-ykfvbypo	294	18	smooth	smooth	JJ
cord-006664-ykfvbypo	294	19	muscle	muscle	NN
cord-006664-ykfvbypo	294	20	cell	cell	NN
cord-006664-ykfvbypo	294	21	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	294	22	.	.	.
cord-006664-ykfvbypo	294	23	'4	'4	''
cord-006664-ykfvbypo	295	1	"	"	``
cord-006664-ykfvbypo	295	2	This	this	DT
cord-006664-ykfvbypo	295	3	suggests	suggest	VBZ
cord-006664-ykfvbypo	295	4	that	that	IN
cord-006664-ykfvbypo	295	5	the	the	DT
cord-006664-ykfvbypo	295	6	prevailing	prevail	VBG
cord-006664-ykfvbypo	295	7	influences	influence	NNS
cord-006664-ykfvbypo	295	8	in	in	IN
cord-006664-ykfvbypo	295	9	determining	determine	VBG
cord-006664-ykfvbypo	295	10	the	the	DT
cord-006664-ykfvbypo	295	11	occurrence	occurrence	NN
cord-006664-ykfvbypo	295	12	of	of	IN
cord-006664-ykfvbypo	295	13	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	295	14	in	in	IN
cord-006664-ykfvbypo	295	15	vascular	vascular	JJ
cord-006664-ykfvbypo	295	16	smooth	smooth	JJ
cord-006664-ykfvbypo	295	17	muscle	muscle	NN
cord-006664-ykfvbypo	295	18	cells	cell	NNS
cord-006664-ykfvbypo	295	19	include	include	VBP
cord-006664-ykfvbypo	295	20	proto	proto	JJ
cord-006664-ykfvbypo	295	21	-	-	HYPH
cord-006664-ykfvbypo	295	22	oncogene	oncogene	NN
cord-006664-ykfvbypo	295	23	expression	expression	NN
cord-006664-ykfvbypo	295	24	and	and	CC
cord-006664-ykfvbypo	295	25	local	local	JJ
cord-006664-ykfvbypo	295	26	cytokine	cytokine	NN
cord-006664-ykfvbypo	295	27	interactions	interaction	NNS
cord-006664-ykfvbypo	295	28	.	.	.
cord-006664-ykfvbypo	296	1	The	the	DT
cord-006664-ykfvbypo	296	2	highest	high	JJS
cord-006664-ykfvbypo	296	3	concentration	concentration	NN
cord-006664-ykfvbypo	296	4	of	of	IN
cord-006664-ykfvbypo	296	5	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	296	6	cells	cell	NNS
cord-006664-ykfvbypo	296	7	in	in	IN
cord-006664-ykfvbypo	296	8	an	an	DT
cord-006664-ykfvbypo	296	9	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	296	10	plaque	plaque	NN
cord-006664-ykfvbypo	296	11	appears	appear	VBZ
cord-006664-ykfvbypo	296	12	to	to	TO
cord-006664-ykfvbypo	296	13	be	be	VB
cord-006664-ykfvbypo	296	14	in	in	IN
cord-006664-ykfvbypo	296	15	regions	region	NNS
cord-006664-ykfvbypo	296	16	enriched	enrich	VBN
cord-006664-ykfvbypo	296	17	with	with	IN
cord-006664-ykfvbypo	296	18	macrophages	macrophage	NNS
cord-006664-ykfvbypo	296	19	.	.	.
cord-006664-ykfvbypo	297	1	This	this	DT
cord-006664-ykfvbypo	297	2	may	may	MD
cord-006664-ykfvbypo	297	3	be	be	VB
cord-006664-ykfvbypo	297	4	as	as	IN
cord-006664-ykfvbypo	297	5	a	a	DT
cord-006664-ykfvbypo	297	6	result	result	NN
cord-006664-ykfvbypo	297	7	of	of	IN
cord-006664-ykfvbypo	297	8	induction	induction	NN
cord-006664-ykfvbypo	297	9	of	of	IN
cord-006664-ykfvbypo	297	10	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	297	11	pathways	pathway	NNS
cord-006664-ykfvbypo	297	12	via	via	IN
cord-006664-ykfvbypo	297	13	macrophage	macrophage	NN
cord-006664-ykfvbypo	297	14	TNFa	TNFa	NNP
cord-006664-ykfvbypo	297	15	release	release	NN
cord-006664-ykfvbypo	297	16	,	,	,
cord-006664-ykfvbypo	297	17	reactive	reactive	JJ
cord-006664-ykfvbypo	297	18	oxygen	oxygen	NN
cord-006664-ykfvbypo	297	19	species	specie	NNS
cord-006664-ykfvbypo	297	20	generation	generation	NN
cord-006664-ykfvbypo	297	21	or	or	CC
cord-006664-ykfvbypo	297	22	directly	directly	RB
cord-006664-ykfvbypo	297	23	by	by	IN
cord-006664-ykfvbypo	297	24	the	the	DT
cord-006664-ykfvbypo	297	25	production	production	NN
cord-006664-ykfvbypo	297	26	of	of	IN
cord-006664-ykfvbypo	297	27	oxidised	oxidise	VBN
cord-006664-ykfvbypo	297	28	low	low	JJ
cord-006664-ykfvbypo	297	29	density	density	NN
cord-006664-ykfvbypo	297	30	lipoprotein	lipoprotein	NN
cord-006664-ykfvbypo	297	31	(	(	-LRB-
cord-006664-ykfvbypo	297	32	LDL	LDL	NNP
cord-006664-ykfvbypo	297	33	)	)	-RRB-
cord-006664-ykfvbypo	297	34	.	.	.
cord-006664-ykfvbypo	298	1	12	12	CD
cord-006664-ykfvbypo	299	1	*	*	NFP
cord-006664-ykfvbypo	299	2	LDL	ldl	NN
cord-006664-ykfvbypo	299	3	penetration	penetration	NN
cord-006664-ykfvbypo	299	4	of	of	IN
cord-006664-ykfvbypo	299	5	the	the	DT
cord-006664-ykfvbypo	299	6	intima	intima	NN
cord-006664-ykfvbypo	299	7	is	be	VBZ
cord-006664-ykfvbypo	299	8	an	an	DT
cord-006664-ykfvbypo	299	9	initiating	initiate	VBG
cord-006664-ykfvbypo	299	10	pathogenic	pathogenic	JJ
cord-006664-ykfvbypo	299	11	effect	effect	NN
cord-006664-ykfvbypo	299	12	in	in	IN
cord-006664-ykfvbypo	299	13	atherosclerosis	atherosclerosis	NN
cord-006664-ykfvbypo	299	14	.	.	.
cord-006664-ykfvbypo	300	1	125	125	CD
cord-006664-ykfvbypo	301	1	•	•	NNP
cord-006664-ykfvbypo	301	2	'	'	POS
cord-006664-ykfvbypo	301	3	26	26	CD
cord-006664-ykfvbypo	302	1	Its	-PRON-	PRP$
cord-006664-ykfvbypo	302	2	subsequent	subsequent	JJ
cord-006664-ykfvbypo	302	3	oxidative	oxidative	JJ
cord-006664-ykfvbypo	302	4	modification	modification	NN
cord-006664-ykfvbypo	302	5	by	by	IN
cord-006664-ykfvbypo	302	6	macrophages	macrophage	NNS
cord-006664-ykfvbypo	302	7	and	and	CC
cord-006664-ykfvbypo	302	8	other	other	JJ
cord-006664-ykfvbypo	302	9	cells	cell	NNS
cord-006664-ykfvbypo	302	10	precedes	precede	VBZ
cord-006664-ykfvbypo	302	11	foam	foam	NN
cord-006664-ykfvbypo	302	12	cell	cell	NN
cord-006664-ykfvbypo	302	13	formation	formation	NN
cord-006664-ykfvbypo	302	14	.	.	.
cord-006664-ykfvbypo	303	1	The	the	DT
cord-006664-ykfvbypo	303	2	effect	effect	NN
cord-006664-ykfvbypo	303	3	of	of	IN
cord-006664-ykfvbypo	303	4	oxidised	oxidise	VBN
cord-006664-ykfvbypo	303	5	LDL	ldl	NN
cord-006664-ykfvbypo	303	6	in	in	IN
cord-006664-ykfvbypo	303	7	directly	directly	RB
cord-006664-ykfvbypo	303	8	precipitating	precipitate	VBG
cord-006664-ykfvbypo	303	9	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	303	10	in	in	IN
cord-006664-ykfvbypo	303	11	cultured	cultured	JJ
cord-006664-ykfvbypo	303	12	endothelial	endothelial	JJ
cord-006664-ykfvbypo	303	13	cells	cell	NNS
cord-006664-ykfvbypo	303	14	is	be	VBZ
cord-006664-ykfvbypo	303	15	significant	significant	JJ
cord-006664-ykfvbypo	303	16	as	as	IN
cord-006664-ykfvbypo	303	17	it	-PRON-	PRP
cord-006664-ykfvbypo	303	18	implies	imply	VBZ
cord-006664-ykfvbypo	303	19	a	a	DT
cord-006664-ykfvbypo	303	20	pathway	pathway	NN
cord-006664-ykfvbypo	303	21	for	for	IN
cord-006664-ykfvbypo	303	22	the	the	DT
cord-006664-ykfvbypo	303	23	participation	participation	NN
cord-006664-ykfvbypo	303	24	of	of	IN
cord-006664-ykfvbypo	303	25	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	303	26	in	in	IN
cord-006664-ykfvbypo	303	27	the	the	DT
cord-006664-ykfvbypo	303	28	initial	initial	JJ
cord-006664-ykfvbypo	303	29	pathogenesis	pathogenesis	NN
cord-006664-ykfvbypo	303	30	and	and	CC
cord-006664-ykfvbypo	303	31	progression	progression	NN
cord-006664-ykfvbypo	303	32	of	of	IN
cord-006664-ykfvbypo	303	33	atherosclerosis	atherosclerosis	NN
cord-006664-ykfvbypo	303	34	.	.	.
cord-006664-ykfvbypo	304	1	'	'	``
cord-006664-ykfvbypo	304	2	27	27	CD
cord-006664-ykfvbypo	305	1	This	this	DT
cord-006664-ykfvbypo	305	2	effect	effect	NN
cord-006664-ykfvbypo	305	3	has	have	VBZ
cord-006664-ykfvbypo	305	4	been	be	VBN
cord-006664-ykfvbypo	305	5	exploited	exploit	VBN
cord-006664-ykfvbypo	305	6	therapeutically	therapeutically	RB
cord-006664-ykfvbypo	305	7	in	in	IN
cord-006664-ykfvbypo	305	8	LDL	ldl	NN
cord-006664-ykfvbypo	305	9	receptor	receptor	NN
cord-006664-ykfvbypo	305	10	knockout	knockout	NN
cord-006664-ykfvbypo	305	11	mice	mouse	NNS
cord-006664-ykfvbypo	305	12	by	by	IN
cord-006664-ykfvbypo	305	13	using	use	VBG
cord-006664-ykfvbypo	305	14	the	the	DT
cord-006664-ykfvbypo	305	15	NO	no	DT
cord-006664-ykfvbypo	305	16	precursor	precursor	NN
cord-006664-ykfvbypo	305	17	L	l	NN
cord-006664-ykfvbypo	305	18	-	-	HYPH
cord-006664-ykfvbypo	305	19	arginine	arginine	NN
cord-006664-ykfvbypo	305	20	to	to	TO
cord-006664-ykfvbypo	305	21	prevent	prevent	VB
cord-006664-ykfvbypo	305	22	and	and	CC
cord-006664-ykfvbypo	305	23	induce	induce	VB
cord-006664-ykfvbypo	305	24	regression	regression	NN
cord-006664-ykfvbypo	305	25	of	of	IN
cord-006664-ykfvbypo	305	26	atherosclerosis	atherosclerosis	NN
cord-006664-ykfvbypo	305	27	in	in	IN
cord-006664-ykfvbypo	305	28	hypercholesterolaemic	hypercholesterolaemic	NNP
cord-006664-ykfvbypo	305	29	animals	animal	NNS
cord-006664-ykfvbypo	305	30	,	,	,
cord-006664-ykfvbypo	305	31	possibly	possibly	RB
cord-006664-ykfvbypo	305	32	by	by	IN
cord-006664-ykfvbypo	305	33	an	an	DT
cord-006664-ykfvbypo	305	34	antioxidant	antioxidant	JJ
cord-006664-ykfvbypo	305	35	effect	effect	NN
cord-006664-ykfvbypo	305	36	or	or	CC
cord-006664-ykfvbypo	305	37	alternatively	alternatively	RB
cord-006664-ykfvbypo	305	38	directly	directly	RB
cord-006664-ykfvbypo	305	39	via	via	IN
cord-006664-ykfvbypo	305	40	NO	no	NN
cord-006664-ykfvbypo	305	41	.	.	.
cord-006664-ykfvbypo	305	42	'	'	''
cord-006664-ykfvbypo	306	1	28	28	CD
cord-006664-ykfvbypo	307	1	Advanced	advanced	JJ
cord-006664-ykfvbypo	307	2	human	human	JJ
cord-006664-ykfvbypo	307	3	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	307	4	plaques	plaque	NNS
cord-006664-ykfvbypo	307	5	contain	contain	VBP
cord-006664-ykfvbypo	307	6	sclerotic	sclerotic	JJ
cord-006664-ykfvbypo	307	7	hypocellular	hypocellular	JJ
cord-006664-ykfvbypo	307	8	regions	region	NNS
cord-006664-ykfvbypo	307	9	.	.	.
cord-006664-ykfvbypo	308	1	This	this	DT
cord-006664-ykfvbypo	308	2	has	have	VBZ
cord-006664-ykfvbypo	308	3	led	lead	VBN
cord-006664-ykfvbypo	308	4	to	to	IN
cord-006664-ykfvbypo	308	5	the	the	DT
cord-006664-ykfvbypo	308	6	suggestion	suggestion	NN
cord-006664-ykfvbypo	308	7	that	that	IN
cord-006664-ykfvbypo	308	8	these	these	DT
cord-006664-ykfvbypo	308	9	areas	area	NNS
cord-006664-ykfvbypo	308	10	arise	arise	VBP
cord-006664-ykfvbypo	308	11	due	due	JJ
cord-006664-ykfvbypo	308	12	to	to	IN
cord-006664-ykfvbypo	308	13	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	308	14	cell	cell	NN
cord-006664-ykfvbypo	308	15	death	death	NN
cord-006664-ykfvbypo	308	16	.	.	.
cord-006664-ykfvbypo	309	1	19	19	CD
cord-006664-ykfvbypo	310	1	As	as	IN
cord-006664-ykfvbypo	310	2	part	part	NN
cord-006664-ykfvbypo	310	3	of	of	IN
cord-006664-ykfvbypo	310	4	the	the	DT
cord-006664-ykfvbypo	310	5	Coronary	Coronary	NNP
cord-006664-ykfvbypo	310	6	Angioplasty	Angioplasty	NNP
cord-006664-ykfvbypo	310	7	Versus	Versus	NNP
cord-006664-ykfvbypo	310	8	Excisional	Excisional	NNP
cord-006664-ykfvbypo	310	9	Atherectomy	Atherectomy	NNP
cord-006664-ykfvbypo	310	10	Trial	Trial	NNP
cord-006664-ykfvbypo	310	11	(	(	-LRB-
cord-006664-ykfvbypo	310	12	CAVEAT	CAVEAT	NNP
cord-006664-ykfvbypo	310	13	)	)	-RRB-
cord-006664-ykfvbypo	310	14	,	,	,
cord-006664-ykfvbypo	310	15	93	93	CD
cord-006664-ykfvbypo	310	16	%	%	NN
cord-006664-ykfvbypo	310	17	of	of	IN
cord-006664-ykfvbypo	310	18	the	the	DT
cord-006664-ykfvbypo	310	19	primary	primary	JJ
cord-006664-ykfvbypo	310	20	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	310	21	plaques	plaque	NNS
cord-006664-ykfvbypo	310	22	obtained	obtain	VBN
cord-006664-ykfvbypo	310	23	by	by	IN
cord-006664-ykfvbypo	310	24	directional	directional	JJ
cord-006664-ykfvbypo	310	25	atherectomy	atherectomy	NN
cord-006664-ykfvbypo	310	26	were	be	VBD
cord-006664-ykfvbypo	310	27	found	find	VBN
cord-006664-ykfvbypo	310	28	to	to	TO
cord-006664-ykfvbypo	310	29	be	be	VB
cord-006664-ykfvbypo	310	30	hypocellular	hypocellular	NNP
cord-006664-ykfvbypo	310	31	.	.	.
cord-006664-ykfvbypo	310	32	129	129	CD
cord-006664-ykfvbypo	311	1	In	in	IN
cord-006664-ykfvbypo	311	2	addition	addition	NN
cord-006664-ykfvbypo	311	3	,	,	,
cord-006664-ykfvbypo	311	4	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	311	5	cell	cell	NN
cord-006664-ykfvbypo	311	6	death	death	NN
cord-006664-ykfvbypo	311	7	of	of	IN
cord-006664-ykfvbypo	311	8	proliferating	proliferate	VBG
cord-006664-ykfvbypo	311	9	smooth	smooth	JJ
cord-006664-ykfvbypo	311	10	muscle	muscle	NN
cord-006664-ykfvbypo	311	11	cells	cell	NNS
cord-006664-ykfvbypo	311	12	has	have	VBZ
cord-006664-ykfvbypo	311	13	been	be	VBN
cord-006664-ykfvbypo	311	14	shown	show	VBN
cord-006664-ykfvbypo	311	15	to	to	TO
cord-006664-ykfvbypo	311	16	control	control	VB
cord-006664-ykfvbypo	311	17	their	-PRON-	PRP$
cord-006664-ykfvbypo	311	18	numbers	number	NNS
cord-006664-ykfvbypo	311	19	after	after	IN
cord-006664-ykfvbypo	311	20	injury	injury	NN
cord-006664-ykfvbypo	311	21	such	such	JJ
cord-006664-ykfvbypo	311	22	as	as	IN
cord-006664-ykfvbypo	311	23	atherectomy	atherectomy	NN
cord-006664-ykfvbypo	311	24	.	.	.
cord-006664-ykfvbypo	312	1	Fas	Fas	NNP
cord-006664-ykfvbypo	312	2	is	be	VBZ
cord-006664-ykfvbypo	312	3	widely	widely	RB
cord-006664-ykfvbypo	312	4	expressed	express	VBN
cord-006664-ykfvbypo	312	5	in	in	IN
cord-006664-ykfvbypo	312	6	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	312	7	lesions	lesion	NNS
cord-006664-ykfvbypo	312	8	,	,	,
cord-006664-ykfvbypo	312	9	suggesting	suggest	VBG
cord-006664-ykfvbypo	312	10	a	a	DT
cord-006664-ykfvbypo	312	11	potential	potential	JJ
cord-006664-ykfvbypo	312	12	receptor	receptor	NN
cord-006664-ykfvbypo	312	13	-	-	HYPH
cord-006664-ykfvbypo	312	14	mediated	mediate	VBN
cord-006664-ykfvbypo	312	15	mechanism	mechanism	NN
cord-006664-ykfvbypo	312	16	of	of	IN
cord-006664-ykfvbypo	312	17	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	312	18	death	death	NN
cord-006664-ykfvbypo	312	19	within	within	IN
cord-006664-ykfvbypo	312	20	such	such	JJ
cord-006664-ykfvbypo	312	21	lesions	lesion	NNS
cord-006664-ykfvbypo	312	22	.	.	.
cord-006664-ykfvbypo	313	1	14	14	CD
cord-006664-ykfvbypo	313	2	'	'	``
cord-006664-ykfvbypo	313	3	Dong	Dong	NNP
cord-006664-ykfvbypo	313	4	et	et	FW
cord-006664-ykfvbypo	313	5	al	al	NNP
cord-006664-ykfvbypo	313	6	have	have	VBP
cord-006664-ykfvbypo	313	7	also	also	RB
cord-006664-ykfvbypo	313	8	shown	show	VBN
cord-006664-ykfvbypo	313	9	Fas	Fas	NNP
cord-006664-ykfvbypo	313	10	-	-	HYPH
cord-006664-ykfvbypo	313	11	mediated	mediate	VBN
cord-006664-ykfvbypo	313	12	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	313	13	cell	cell	NN
cord-006664-ykfvbypo	313	14	death	death	NN
cord-006664-ykfvbypo	313	15	to	to	TO
cord-006664-ykfvbypo	313	16	be	be	VB
cord-006664-ykfvbypo	313	17	associated	associate	VBN
cord-006664-ykfvbypo	313	18	with	with	IN
cord-006664-ykfvbypo	313	19	post	post	JJ
cord-006664-ykfvbypo	313	20	-	-	JJ
cord-006664-ykfvbypo	313	21	transplant	transplant	JJ
cord-006664-ykfvbypo	313	22	coronary	coronary	JJ
cord-006664-ykfvbypo	313	23	artery	artery	NN
cord-006664-ykfvbypo	313	24	disease	disease	NN
cord-006664-ykfvbypo	313	25	.	.	.
cord-006664-ykfvbypo	314	1	"	"	''
cord-006664-ykfvbypo	315	1	The	the	DT
cord-006664-ykfvbypo	315	2	endothelial	endothelial	JJ
cord-006664-ykfvbypo	315	3	cell	cell	NN
cord-006664-ykfvbypo	315	4	fulfils	fulfil	VBZ
cord-006664-ykfvbypo	315	5	an	an	DT
cord-006664-ykfvbypo	315	6	interactive	interactive	JJ
cord-006664-ykfvbypo	315	7	role	role	NN
cord-006664-ykfvbypo	315	8	inhibiting	inhibit	VBG
cord-006664-ykfvbypo	315	9	proliferation	proliferation	NN
cord-006664-ykfvbypo	315	10	of	of	IN
cord-006664-ykfvbypo	315	11	adjoining	adjoining	JJ
cord-006664-ykfvbypo	315	12	cells	cell	NNS
cord-006664-ykfvbypo	315	13	,	,	,
cord-006664-ykfvbypo	315	14	thrombus	thrombus	NN
cord-006664-ykfvbypo	315	15	formation	formation	NN
cord-006664-ykfvbypo	315	16	and	and	CC
cord-006664-ykfvbypo	315	17	leucocyte	leucocyte	NN
cord-006664-ykfvbypo	315	18	adhesion	adhesion	NN
cord-006664-ykfvbypo	315	19	while	while	IN
cord-006664-ykfvbypo	315	20	simultaneously	simultaneously	RB
cord-006664-ykfvbypo	315	21	regulating	regulate	VBG
cord-006664-ykfvbypo	315	22	vasomotor	vasomotor	NN
cord-006664-ykfvbypo	315	23	tone	tone	NN
cord-006664-ykfvbypo	315	24	in	in	IN
cord-006664-ykfvbypo	315	25	response	response	NN
cord-006664-ykfvbypo	315	26	to	to	IN
cord-006664-ykfvbypo	315	27	tissue	tissue	NN
cord-006664-ykfvbypo	315	28	requirements	requirement	NNS
cord-006664-ykfvbypo	315	29	or	or	CC
cord-006664-ykfvbypo	315	30	systemic	systemic	JJ
cord-006664-ykfvbypo	315	31	stimuli	stimulus	NNS
cord-006664-ykfvbypo	315	32	.	.	.
cord-006664-ykfvbypo	316	1	Endothelial	endothelial	JJ
cord-006664-ykfvbypo	316	2	dysfunction	dysfunction	NN
cord-006664-ykfvbypo	316	3	contributes	contribute	VBZ
cord-006664-ykfvbypo	316	4	to	to	IN
cord-006664-ykfvbypo	316	5	abnormalities	abnormality	NNS
cord-006664-ykfvbypo	316	6	of	of	IN
cord-006664-ykfvbypo	316	7	these	these	DT
cord-006664-ykfvbypo	316	8	processes	process	NNS
cord-006664-ykfvbypo	316	9	.	.	.
cord-006664-ykfvbypo	317	1	In	in	IN
cord-006664-ykfvbypo	317	2	the	the	DT
cord-006664-ykfvbypo	317	3	endothelium	endothelium	NN
cord-006664-ykfvbypo	317	4	,	,	,
cord-006664-ykfvbypo	317	5	loss	loss	NN
cord-006664-ykfvbypo	317	6	of	of	IN
cord-006664-ykfvbypo	317	7	integrin	integrin	NN
cord-006664-ykfvbypo	317	8	-	-	HYPH
cord-006664-ykfvbypo	317	9	mediated	mediate	VBN
cord-006664-ykfvbypo	317	10	cell	cell	NN
cord-006664-ykfvbypo	317	11	matrix	matrix	NN
cord-006664-ykfvbypo	317	12	contact	contact	NN
cord-006664-ykfvbypo	317	13	results	result	NNS
cord-006664-ykfvbypo	317	14	in	in	IN
cord-006664-ykfvbypo	317	15	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	317	16	cell	cell	NN
cord-006664-ykfvbypo	317	17	death	death	NN
cord-006664-ykfvbypo	317	18	known	know	VBN
cord-006664-ykfvbypo	317	19	as	as	IN
cord-006664-ykfvbypo	317	20	`	`	''
cord-006664-ykfvbypo	317	21	anoikis	anoikis	NNP
cord-006664-ykfvbypo	317	22	'	'	''
cord-006664-ykfvbypo	317	23	.	.	.
cord-006664-ykfvbypo	318	1	The	the	DT
cord-006664-ykfvbypo	318	2	term	term	NN
cord-006664-ykfvbypo	318	3	anoikis	anoikis	NN
cord-006664-ykfvbypo	318	4	is	be	VBZ
cord-006664-ykfvbypo	318	5	derived	derive	VBN
cord-006664-ykfvbypo	318	6	from	from	IN
cord-006664-ykfvbypo	318	7	the	the	DT
cord-006664-ykfvbypo	318	8	Greek	greek	JJ
cord-006664-ykfvbypo	318	9	word	word	NN
cord-006664-ykfvbypo	318	10	for	for	IN
cord-006664-ykfvbypo	318	11	homeless	homeless	JJ
cord-006664-ykfvbypo	318	12	and	and	CC
cord-006664-ykfvbypo	318	13	is	be	VBZ
cord-006664-ykfvbypo	318	14	used	use	VBN
cord-006664-ykfvbypo	318	15	in	in	IN
cord-006664-ykfvbypo	318	16	this	this	DT
cord-006664-ykfvbypo	318	17	context	context	NN
cord-006664-ykfvbypo	318	18	to	to	TO
cord-006664-ykfvbypo	318	19	denote	denote	VB
cord-006664-ykfvbypo	318	20	a	a	DT
cord-006664-ykfvbypo	318	21	cell	cell	NN
cord-006664-ykfvbypo	318	22	dying	die	VBG
cord-006664-ykfvbypo	318	23	by	by	IN
cord-006664-ykfvbypo	318	24	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	318	25	having	have	VBG
cord-006664-ykfvbypo	318	26	being	be	VBG
cord-006664-ykfvbypo	318	27	displaced	displace	VBN
cord-006664-ykfvbypo	318	28	from	from	IN
cord-006664-ykfvbypo	318	29	its	-PRON-	PRP$
cord-006664-ykfvbypo	318	30	normal	normal	JJ
cord-006664-ykfvbypo	318	31	environment	environment	NN
cord-006664-ykfvbypo	318	32	.	.	.
cord-006664-ykfvbypo	319	1	130	130	CD
cord-006664-ykfvbypo	320	1	The	the	DT
cord-006664-ykfvbypo	320	2	death	death	NN
cord-006664-ykfvbypo	320	3	of	of	IN
cord-006664-ykfvbypo	320	4	endothelial	endothelial	JJ
cord-006664-ykfvbypo	320	5	cells	cell	NNS
cord-006664-ykfvbypo	320	6	after	after	IN
cord-006664-ykfvbypo	320	7	detachment	detachment	NN
cord-006664-ykfvbypo	320	8	is	be	VBZ
cord-006664-ykfvbypo	320	9	beneficial	beneficial	JJ
cord-006664-ykfvbypo	320	10	as	as	IN
cord-006664-ykfvbypo	320	11	it	-PRON-	PRP
cord-006664-ykfvbypo	320	12	prevents	prevent	VBZ
cord-006664-ykfvbypo	320	13	detached	detached	JJ
cord-006664-ykfvbypo	320	14	or	or	CC
cord-006664-ykfvbypo	320	15	abnormal	abnormal	JJ
cord-006664-ykfvbypo	320	16	cells	cell	NNS
cord-006664-ykfvbypo	320	17	from	from	IN
cord-006664-ykfvbypo	320	18	reattaching	reattache	VBG
cord-006664-ykfvbypo	320	19	and	and	CC
cord-006664-ykfvbypo	320	20	growing	grow	VBG
cord-006664-ykfvbypo	320	21	in	in	IN
cord-006664-ykfvbypo	320	22	a	a	DT
cord-006664-ykfvbypo	320	23	dysplastic	dysplastic	JJ
cord-006664-ykfvbypo	320	24	fashion	fashion	NN
cord-006664-ykfvbypo	320	25	.	.	.
cord-006664-ykfvbypo	320	26	'	'	''
cord-006664-ykfvbypo	321	1	3	3	LS
cord-006664-ykfvbypo	322	1	Neutrophil	neutrophil	JJ
cord-006664-ykfvbypo	322	2	endothelial	endothelial	JJ
cord-006664-ykfvbypo	322	3	interaction	interaction	NN
cord-006664-ykfvbypo	322	4	is	be	VBZ
cord-006664-ykfvbypo	322	5	a	a	DT
cord-006664-ykfvbypo	322	6	key	key	JJ
cord-006664-ykfvbypo	322	7	element	element	NN
cord-006664-ykfvbypo	322	8	in	in	IN
cord-006664-ykfvbypo	322	9	the	the	DT
cord-006664-ykfvbypo	322	10	development	development	NN
cord-006664-ykfvbypo	322	11	of	of	IN
cord-006664-ykfvbypo	322	12	the	the	DT
cord-006664-ykfvbypo	322	13	adult	adult	NN
cord-006664-ykfvbypo	322	14	respiratory	respiratory	JJ
cord-006664-ykfvbypo	322	15	distress	distress	NN
cord-006664-ykfvbypo	322	16	syndrome	syndrome	NN
cord-006664-ykfvbypo	322	17	(	(	-LRB-
cord-006664-ykfvbypo	322	18	ARDS	ARDS	NNP
cord-006664-ykfvbypo	322	19	)	)	-RRB-
cord-006664-ykfvbypo	322	20	,	,	,
cord-006664-ykfvbypo	322	21	often	often	RB
cord-006664-ykfvbypo	322	22	as	as	IN
cord-006664-ykfvbypo	322	23	a	a	DT
cord-006664-ykfvbypo	322	24	component	component	NN
cord-006664-ykfvbypo	322	25	of	of	IN
cord-006664-ykfvbypo	322	26	SIRS	SIRS	NNP
cord-006664-ykfvbypo	322	27	.	.	.
cord-006664-ykfvbypo	323	1	The	the	DT
cord-006664-ykfvbypo	323	2	endothelial	endothelial	JJ
cord-006664-ykfvbypo	323	3	dysfunction	dysfunction	NN
cord-006664-ykfvbypo	323	4	,	,	,
cord-006664-ykfvbypo	323	5	The	the	DT
cord-006664-ykfvbypo	323	6	role	role	NN
cord-006664-ykfvbypo	323	7	of	of	IN
cord-006664-ykfvbypo	323	8	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	323	9	cell	cell	NN
cord-006664-ykfvbypo	323	10	death	death	NN
cord-006664-ykfvbypo	323	11	in	in	IN
cord-006664-ykfvbypo	323	12	card	card	NN
cord-006664-ykfvbypo	323	13	iovascular	iovascular	JJ
cord-006664-ykfvbypo	323	14	disease	disease	NN
cord-006664-ykfvbypo	323	15	manifested	manifest	VBD
cord-006664-ykfvbypo	323	16	as	as	IN
cord-006664-ykfvbypo	323	17	increased	increase	VBN
cord-006664-ykfvbypo	323	18	capillary	capillary	JJ
cord-006664-ykfvbypo	323	19	permeability	permeability	NN
cord-006664-ykfvbypo	323	20	in	in	IN
cord-006664-ykfvbypo	323	21	SIRS	SIRS	NNP
cord-006664-ykfvbypo	323	22	,	,	,
cord-006664-ykfvbypo	323	23	is	be	VBZ
cord-006664-ykfvbypo	323	24	partly	partly	RB
cord-006664-ykfvbypo	323	25	as	as	IN
cord-006664-ykfvbypo	323	26	a	a	DT
cord-006664-ykfvbypo	323	27	consequence	consequence	NN
cord-006664-ykfvbypo	323	28	of	of	IN
cord-006664-ykfvbypo	323	29	endothelial	endothelial	JJ
cord-006664-ykfvbypo	323	30	cell	cell	NN
cord-006664-ykfvbypo	323	31	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	323	32	.	.	.
cord-006664-ykfvbypo	324	1	20	20	CD
cord-006664-ykfvbypo	324	2	'	'	POS
cord-006664-ykfvbypo	324	3	13	13	CD
cord-006664-ykfvbypo	324	4	'	'	''
cord-006664-ykfvbypo	325	1	It	-PRON-	PRP
cord-006664-ykfvbypo	325	2	has	have	VBZ
cord-006664-ykfvbypo	325	3	been	be	VBN
cord-006664-ykfvbypo	325	4	suggested	suggest	VBN
cord-006664-ykfvbypo	325	5	that	that	IN
cord-006664-ykfvbypo	325	6	,	,	,
cord-006664-ykfvbypo	325	7	as	as	IN
cord-006664-ykfvbypo	325	8	a	a	DT
cord-006664-ykfvbypo	325	9	therapeutic	therapeutic	JJ
cord-006664-ykfvbypo	325	10	strategy	strategy	NN
cord-006664-ykfvbypo	325	11	in	in	IN
cord-006664-ykfvbypo	325	12	sepsis	sepsis	NN
cord-006664-ykfvbypo	325	13	and	and	CC
cord-006664-ykfvbypo	325	14	SIRS	sirs	NN
cord-006664-ykfvbypo	325	15	,	,	,
cord-006664-ykfvbypo	325	16	attenuation	attenuation	NN
cord-006664-ykfvbypo	325	17	of	of	IN
cord-006664-ykfvbypo	325	18	the	the	DT
cord-006664-ykfvbypo	325	19	cellular	cellular	JJ
cord-006664-ykfvbypo	325	20	response	response	NN
cord-006664-ykfvbypo	325	21	to	to	IN
cord-006664-ykfvbypo	325	22	this	this	DT
cord-006664-ykfvbypo	325	23	process	process	NN
cord-006664-ykfvbypo	325	24	may	may	MD
cord-006664-ykfvbypo	325	25	be	be	VB
cord-006664-ykfvbypo	325	26	more	more	RBR
cord-006664-ykfvbypo	325	27	beneficial	beneficial	JJ
cord-006664-ykfvbypo	325	28	than	than	IN
cord-006664-ykfvbypo	325	29	dealing	deal	VBG
cord-006664-ykfvbypo	325	30	with	with	IN
cord-006664-ykfvbypo	325	31	the	the	DT
cord-006664-ykfvbypo	325	32	extracellular	extracellular	JJ
cord-006664-ykfvbypo	325	33	mediators	mediator	NNS
cord-006664-ykfvbypo	325	34	of	of	IN
cord-006664-ykfvbypo	325	35	this	this	DT
cord-006664-ykfvbypo	325	36	process	process	NN
cord-006664-ykfvbypo	325	37	.	.	.
cord-006664-ykfvbypo	326	1	It	-PRON-	PRP
cord-006664-ykfvbypo	326	2	has	have	VBZ
cord-006664-ykfvbypo	326	3	been	be	VBN
cord-006664-ykfvbypo	326	4	demonstrated	demonstrate	VBN
cord-006664-ykfvbypo	326	5	in	in	IN
cord-006664-ykfvbypo	326	6	vitro	vitro	FW
cord-006664-ykfvbypo	326	7	that	that	IN
cord-006664-ykfvbypo	326	8	induction	induction	NN
cord-006664-ykfvbypo	326	9	of	of	IN
cord-006664-ykfvbypo	326	10	heat	heat	NN
cord-006664-ykfvbypo	326	11	shock	shock	NN
cord-006664-ykfvbypo	326	12	proteins	protein	NNS
cord-006664-ykfvbypo	326	13	can	can	MD
cord-006664-ykfvbypo	326	14	protect	protect	VB
cord-006664-ykfvbypo	326	15	endothelial	endothelial	JJ
cord-006664-ykfvbypo	326	16	cells	cell	NNS
cord-006664-ykfvbypo	326	17	against	against	IN
cord-006664-ykfvbypo	326	18	subsequent	subsequent	JJ
cord-006664-ykfvbypo	326	19	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	326	20	in	in	IN
cord-006664-ykfvbypo	326	21	response	response	NN
cord-006664-ykfvbypo	326	22	to	to	IN
cord-006664-ykfvbypo	326	23	a	a	DT
cord-006664-ykfvbypo	326	24	SIRS	SIRS	NNP
cord-006664-ykfvbypo	326	25	insult	insult	NN
cord-006664-ykfvbypo	326	26	model	model	NN
cord-006664-ykfvbypo	326	27	.	.	.
cord-006664-ykfvbypo	327	1	13334	13334	CD
cord-006664-ykfvbypo	328	1	The	the	DT
cord-006664-ykfvbypo	328	2	vascular	vascular	JJ
cord-006664-ykfvbypo	328	3	endothelium	endothelium	NN
cord-006664-ykfvbypo	328	4	response	response	NN
cord-006664-ykfvbypo	328	5	to	to	IN
cord-006664-ykfvbypo	328	6	injury	injury	NN
cord-006664-ykfvbypo	328	7	involves	involve	VBZ
cord-006664-ykfvbypo	328	8	smooth	smooth	JJ
cord-006664-ykfvbypo	328	9	muscle	muscle	NN
cord-006664-ykfvbypo	328	10	cell	cell	NN
cord-006664-ykfvbypo	328	11	proliferation	proliferation	NN
cord-006664-ykfvbypo	328	12	and	and	CC
cord-006664-ykfvbypo	328	13	neointimal	neointimal	JJ
cord-006664-ykfvbypo	328	14	formation	formation	NN
cord-006664-ykfvbypo	328	15	.	.	.
cord-006664-ykfvbypo	329	1	This	this	DT
cord-006664-ykfvbypo	329	2	proliferation	proliferation	NN
cord-006664-ykfvbypo	329	3	continues	continue	VBZ
cord-006664-ykfvbypo	329	4	for	for	IN
cord-006664-ykfvbypo	329	5	up	up	IN
cord-006664-ykfvbypo	329	6	to	to	TO
cord-006664-ykfvbypo	329	7	12	12	CD
cord-006664-ykfvbypo	329	8	weeks	week	NNS
cord-006664-ykfvbypo	329	9	.	.	.
cord-006664-ykfvbypo	330	1	If	if	IN
cord-006664-ykfvbypo	330	2	abnormally	abnormally	RB
cord-006664-ykfvbypo	330	3	regulated	regulate	VBN
cord-006664-ykfvbypo	330	4	proliferation	proliferation	NN
cord-006664-ykfvbypo	330	5	proceeds	proceed	NNS
cord-006664-ykfvbypo	330	6	unchecked	unchecked	JJ
cord-006664-ykfvbypo	330	7	,	,	,
cord-006664-ykfvbypo	330	8	then	then	RB
cord-006664-ykfvbypo	330	9	an	an	DT
cord-006664-ykfvbypo	330	10	overexuberant	overexuberant	JJ
cord-006664-ykfvbypo	330	11	thickening	thickening	NN
cord-006664-ykfvbypo	330	12	of	of	IN
cord-006664-ykfvbypo	330	13	the	the	DT
cord-006664-ykfvbypo	330	14	intima	intima	NN
cord-006664-ykfvbypo	330	15	will	will	MD
cord-006664-ykfvbypo	330	16	result	result	VB
cord-006664-ykfvbypo	330	17	.	.	.
cord-006664-ykfvbypo	331	1	However	however	RB
cord-006664-ykfvbypo	331	2	,	,	,
cord-006664-ykfvbypo	331	3	the	the	DT
cord-006664-ykfvbypo	331	4	total	total	JJ
cord-006664-ykfvbypo	331	5	number	number	NN
cord-006664-ykfvbypo	331	6	of	of	IN
cord-006664-ykfvbypo	331	7	cells	cell	NNS
cord-006664-ykfvbypo	331	8	present	present	JJ
cord-006664-ykfvbypo	331	9	after	after	IN
cord-006664-ykfvbypo	331	10	such	such	JJ
cord-006664-ykfvbypo	331	11	injury	injury	NN
cord-006664-ykfvbypo	331	12	is	be	VBZ
cord-006664-ykfvbypo	331	13	typically	typically	RB
cord-006664-ykfvbypo	331	14	maximal	maximal	JJ
cord-006664-ykfvbypo	331	15	at	at	IN
cord-006664-ykfvbypo	331	16	two	two	CD
cord-006664-ykfvbypo	331	17	weeks	week	NNS
cord-006664-ykfvbypo	331	18	.	.	.
cord-006664-ykfvbypo	331	19	'	'	''
cord-006664-ykfvbypo	332	1	"	"	``
cord-006664-ykfvbypo	332	2	The	the	DT
cord-006664-ykfvbypo	332	3	rate	rate	NN
cord-006664-ykfvbypo	332	4	-	-	HYPH
cord-006664-ykfvbypo	332	5	limiting	limit	VBG
cord-006664-ykfvbypo	332	6	factor	factor	NN
cord-006664-ykfvbypo	332	7	in	in	IN
cord-006664-ykfvbypo	332	8	this	this	DT
cord-006664-ykfvbypo	332	9	context	context	NN
cord-006664-ykfvbypo	332	10	is	be	VBZ
cord-006664-ykfvbypo	332	11	smooth	smooth	JJ
cord-006664-ykfvbypo	332	12	muscle	muscle	NN
cord-006664-ykfvbypo	332	13	cell	cell	NN
cord-006664-ykfvbypo	332	14	deletion	deletion	NN
cord-006664-ykfvbypo	332	15	by	by	IN
cord-006664-ykfvbypo	332	16	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	332	17	,	,	,
cord-006664-ykfvbypo	332	18	which	which	WDT
cord-006664-ykfvbypo	332	19	intercedes	intercede	VBZ
cord-006664-ykfvbypo	332	20	to	to	TO
cord-006664-ykfvbypo	332	21	control	control	VB
cord-006664-ykfvbypo	332	22	cell	cell	NN
cord-006664-ykfvbypo	332	23	numbers	number	NNS
cord-006664-ykfvbypo	332	24	.	.	.
cord-006664-ykfvbypo	333	1	15	15	CD
cord-006664-ykfvbypo	334	1	The	the	DT
cord-006664-ykfvbypo	334	2	inference	inference	NN
cord-006664-ykfvbypo	334	3	,	,	,
cord-006664-ykfvbypo	334	4	therefore	therefore	RB
cord-006664-ykfvbypo	334	5	,	,	,
cord-006664-ykfvbypo	334	6	is	be	VBZ
cord-006664-ykfvbypo	334	7	that	that	IN
cord-006664-ykfvbypo	334	8	this	this	DT
cord-006664-ykfvbypo	334	9	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	334	10	control	control	NN
cord-006664-ykfvbypo	334	11	allows	allow	VBZ
cord-006664-ykfvbypo	334	12	neointimal	neointimal	JJ
cord-006664-ykfvbypo	334	13	thickness	thickness	NN
cord-006664-ykfvbypo	334	14	to	to	TO
cord-006664-ykfvbypo	334	15	remain	remain	VB
cord-006664-ykfvbypo	334	16	constant	constant	JJ
cord-006664-ykfvbypo	334	17	despite	despite	IN
cord-006664-ykfvbypo	334	18	a	a	DT
cord-006664-ykfvbypo	334	19	continued	continued	JJ
cord-006664-ykfvbypo	334	20	smooth	smooth	JJ
cord-006664-ykfvbypo	334	21	muscle	muscle	NN
cord-006664-ykfvbypo	334	22	cell	cell	NN
cord-006664-ykfvbypo	334	23	proliferation	proliferation	NN
cord-006664-ykfvbypo	334	24	response	response	NN
cord-006664-ykfvbypo	334	25	to	to	IN
cord-006664-ykfvbypo	334	26	injury	injury	NN
cord-006664-ykfvbypo	334	27	.	.	.
cord-006664-ykfvbypo	335	1	13	13	CD
cord-006664-ykfvbypo	335	2	'	'	``
cord-006664-ykfvbypo	335	3	Pearlman	Pearlman	NNP
cord-006664-ykfvbypo	335	4	et	et	NNP
cord-006664-ykfvbypo	335	5	al	al	NNP
cord-006664-ykfvbypo	335	6	showed	show	VBD
cord-006664-ykfvbypo	335	7	that	that	IN
cord-006664-ykfvbypo	335	8	extensive	extensive	JJ
cord-006664-ykfvbypo	335	9	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	335	10	is	be	VBZ
cord-006664-ykfvbypo	335	11	detectable	detectable	JJ
cord-006664-ykfvbypo	335	12	in	in	IN
cord-006664-ykfvbypo	335	13	an	an	DT
cord-006664-ykfvbypo	335	14	animal	animal	NN
cord-006664-ykfvbypo	335	15	model	model	NN
cord-006664-ykfvbypo	335	16	of	of	IN
cord-006664-ykfvbypo	335	17	intimal	intimal	JJ
cord-006664-ykfvbypo	335	18	injury	injury	NN
cord-006664-ykfvbypo	335	19	as	as	RB
cord-006664-ykfvbypo	335	20	early	early	RB
cord-006664-ykfvbypo	335	21	as	as	IN
cord-006664-ykfvbypo	335	22	30	30	CD
cord-006664-ykfvbypo	335	23	minutes	minute	NNS
cord-006664-ykfvbypo	335	24	post	post	NN
cord-006664-ykfvbypo	335	25	-	-	JJ
cord-006664-ykfvbypo	335	26	injury	injury	NN
cord-006664-ykfvbypo	335	27	.	.	.
cord-006664-ykfvbypo	336	1	However	however	RB
cord-006664-ykfvbypo	336	2	,	,	,
cord-006664-ykfvbypo	336	3	no	no	DT
cord-006664-ykfvbypo	336	4	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	336	5	was	be	VBD
cord-006664-ykfvbypo	336	6	seen	see	VBN
cord-006664-ykfvbypo	336	7	in	in	IN
cord-006664-ykfvbypo	336	8	normal	normal	JJ
cord-006664-ykfvbypo	336	9	vessels.82	vessels.82	NN
cord-006664-ykfvbypo	337	1	In	in	IN
cord-006664-ykfvbypo	337	2	neointimal	neointimal	JJ
cord-006664-ykfvbypo	337	3	hyperplasia	hyperplasia	NN
cord-006664-ykfvbypo	337	4	,	,	,
cord-006664-ykfvbypo	337	5	proto	proto	JJ
cord-006664-ykfvbypo	337	6	-	-	HYPH
cord-006664-ykfvbypo	337	7	oncogene	oncogene	NN
cord-006664-ykfvbypo	337	8	controls	control	NNS
cord-006664-ykfvbypo	337	9	of	of	IN
cord-006664-ykfvbypo	337	10	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	337	11	act	act	NNP
cord-006664-ykfvbypo	337	12	as	as	IN
cord-006664-ykfvbypo	337	13	molecular	molecular	JJ
cord-006664-ykfvbypo	337	14	thermostats	thermostat	NNS
cord-006664-ykfvbypo	337	15	balancing	balance	VBG
cord-006664-ykfvbypo	337	16	cell	cell	NN
cord-006664-ykfvbypo	337	17	death	death	NN
cord-006664-ykfvbypo	337	18	versus	versus	IN
cord-006664-ykfvbypo	337	19	proliferation	proliferation	NN
cord-006664-ykfvbypo	337	20	,	,	,
cord-006664-ykfvbypo	337	21	which	which	WDT
cord-006664-ykfvbypo	337	22	determines	determine	VBZ
cord-006664-ykfvbypo	337	23	cell	cell	NN
cord-006664-ykfvbypo	337	24	numbers	number	NNS
cord-006664-ykfvbypo	337	25	and	and	CC
cord-006664-ykfvbypo	337	26	survival	survival	NN
cord-006664-ykfvbypo	337	27	.	.	.
cord-006664-ykfvbypo	338	1	81	81	CD
cord-006664-ykfvbypo	339	1	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	339	2	is	be	VBZ
cord-006664-ykfvbypo	339	3	observed	observe	VBN
cord-006664-ykfvbypo	339	4	more	more	RBR
cord-006664-ykfvbypo	339	5	frequently	frequently	RB
cord-006664-ykfvbypo	339	6	in	in	IN
cord-006664-ykfvbypo	339	7	restenotic	restenotic	JJ
cord-006664-ykfvbypo	339	8	than	than	IN
cord-006664-ykfvbypo	339	9	primary	primary	JJ
cord-006664-ykfvbypo	339	10	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	339	11	lesions.2	lesions.2	JJ
cord-006664-ykfvbypo	339	12	°	°	NN
cord-006664-ykfvbypo	340	1	This	this	DT
cord-006664-ykfvbypo	340	2	is	be	VBZ
cord-006664-ykfvbypo	340	3	again	again	RB
cord-006664-ykfvbypo	340	4	consistent	consistent	JJ
cord-006664-ykfvbypo	340	5	with	with	IN
cord-006664-ykfvbypo	340	6	the	the	DT
cord-006664-ykfvbypo	340	7	dynamic	dynamic	JJ
cord-006664-ykfvbypo	340	8	interaction	interaction	NN
cord-006664-ykfvbypo	340	9	of	of	IN
cord-006664-ykfvbypo	340	10	cell	cell	NN
cord-006664-ykfvbypo	340	11	proliferation	proliferation	NN
cord-006664-ykfvbypo	340	12	and	and	CC
cord-006664-ykfvbypo	340	13	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	340	14	exerting	exert	VBG
cord-006664-ykfvbypo	340	15	homeostatic	homeostatic	JJ
cord-006664-ykfvbypo	340	16	control	control	NN
cord-006664-ykfvbypo	340	17	on	on	IN
cord-006664-ykfvbypo	340	18	cell	cell	NN
cord-006664-ykfvbypo	340	19	numbers	number	NNS
cord-006664-ykfvbypo	340	20	in	in	IN
cord-006664-ykfvbypo	340	21	the	the	DT
cord-006664-ykfvbypo	340	22	context	context	NN
cord-006664-ykfvbypo	340	23	of	of	IN
cord-006664-ykfvbypo	340	24	endothelial	endothelial	JJ
cord-006664-ykfvbypo	340	25	repair	repair	NN
cord-006664-ykfvbypo	340	26	and	and	CC
cord-006664-ykfvbypo	340	27	remodelling	remodelling	NN
cord-006664-ykfvbypo	340	28	.	.	.
cord-006664-ykfvbypo	341	1	This	this	DT
cord-006664-ykfvbypo	341	2	increased	increase	VBN
cord-006664-ykfvbypo	341	3	frequency	frequency	NN
cord-006664-ykfvbypo	341	4	of	of	IN
cord-006664-ykfvbypo	341	5	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	341	6	in	in	IN
cord-006664-ykfvbypo	341	7	restenotic	restenotic	JJ
cord-006664-ykfvbypo	341	8	rather	rather	RB
cord-006664-ykfvbypo	341	9	than	than	IN
cord-006664-ykfvbypo	341	10	primary	primary	JJ
cord-006664-ykfvbypo	341	11	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	341	12	lesions	lesion	NNS
cord-006664-ykfvbypo	341	13	is	be	VBZ
cord-006664-ykfvbypo	341	14	supported	support	VBN
cord-006664-ykfvbypo	341	15	by	by	IN
cord-006664-ykfvbypo	341	16	autopsy	autopsy	JJ
cord-006664-ykfvbypo	341	17	reports	report	NNS
cord-006664-ykfvbypo	341	18	of	of	IN
cord-006664-ykfvbypo	341	19	patients	patient	NNS
cord-006664-ykfvbypo	341	20	dying	die	VBG
cord-006664-ykfvbypo	341	21	after	after	IN
cord-006664-ykfvbypo	341	22	multiple	multiple	JJ
cord-006664-ykfvbypo	341	23	angioplasty	angioplasty	NN
cord-006664-ykfvbypo	341	24	procedures	procedure	NNS
cord-006664-ykfvbypo	341	25	.	.	.
cord-006664-ykfvbypo	341	26	"	"	''
cord-006664-ykfvbypo	342	1	'	'	``
cord-006664-ykfvbypo	342	2	Studies	study	NNS
cord-006664-ykfvbypo	342	3	of	of	IN
cord-006664-ykfvbypo	342	4	specimens	specimen	NNS
cord-006664-ykfvbypo	342	5	obtained	obtain	VBN
cord-006664-ykfvbypo	342	6	by	by	IN
cord-006664-ykfvbypo	342	7	percutaneous	percutaneous	JJ
cord-006664-ykfvbypo	342	8	transluminal	transluminal	NNP
cord-006664-ykfvbypo	342	9	atherectomy	atherectomy	NNP
cord-006664-ykfvbypo	342	10	have	have	VBP
cord-006664-ykfvbypo	342	11	provided	provide	VBN
cord-006664-ykfvbypo	342	12	further	further	JJ
cord-006664-ykfvbypo	342	13	evidence	evidence	NN
cord-006664-ykfvbypo	342	14	of	of	IN
cord-006664-ykfvbypo	342	15	hyperplasia	hyperplasia	NN
cord-006664-ykfvbypo	342	16	being	be	VBG
cord-006664-ykfvbypo	342	17	homeostatically	homeostatically	RB
cord-006664-ykfvbypo	342	18	counterbalanced	counterbalance	VBN
cord-006664-ykfvbypo	342	19	by	by	IN
cord-006664-ykfvbypo	342	20	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	342	21	,	,	,
cord-006664-ykfvbypo	342	22	with	with	IN
cord-006664-ykfvbypo	342	23	both	both	DT
cord-006664-ykfvbypo	342	24	elements	element	NNS
cord-006664-ykfvbypo	342	25	being	be	VBG
cord-006664-ykfvbypo	342	26	more	more	RBR
cord-006664-ykfvbypo	342	27	prominent	prominent	JJ
cord-006664-ykfvbypo	342	28	in	in	IN
cord-006664-ykfvbypo	342	29	restenotic	restenotic	JJ
cord-006664-ykfvbypo	342	30	lesions.-	lesions.-	NNP
cord-006664-ykfvbypo	342	31	°	°	NN
cord-006664-ykfvbypo	342	32	,	,	,
cord-006664-ykfvbypo	342	33	3'-	3'-	CD
cord-006664-ykfvbypo	342	34	An	an	DT
cord-006664-ykfvbypo	342	35	even	even	RB
cord-006664-ykfvbypo	342	36	greater	great	JJR
cord-006664-ykfvbypo	342	37	frequency	frequency	NN
cord-006664-ykfvbypo	342	38	of	of	IN
cord-006664-ykfvbypo	342	39	smooth	smooth	JJ
cord-006664-ykfvbypo	342	40	muscle	muscle	NN
cord-006664-ykfvbypo	342	41	cell	cell	NN
cord-006664-ykfvbypo	342	42	proliferalion	proliferalion	NN
cord-006664-ykfvbypo	342	43	and	and	CC
cord-006664-ykfvbypo	342	44	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	342	45	is	be	VBZ
cord-006664-ykfvbypo	342	46	seen	see	VBN
cord-006664-ykfvbypo	342	47	in	in	IN
cord-006664-ykfvbypo	342	48	neointimal	neointimal	JJ
cord-006664-ykfvbypo	342	49	hyperplasia	hyperplasia	NN
cord-006664-ykfvbypo	342	50	complicating	complicate	VBG
cord-006664-ykfvbypo	342	51	stent	stent	NN
cord-006664-ykfvbypo	342	52	restenosis	restenosis	NN
cord-006664-ykfvbypo	342	53	.	.	.
cord-006664-ykfvbypo	343	1	20,138	20,138	CD
cord-006664-ykfvbypo	343	2	.	.	.
cord-006664-ykfvbypo	344	1	148	148	CD
cord-006664-ykfvbypo	345	1	The	the	DT
cord-006664-ykfvbypo	345	2	combined	combined	JJ
cord-006664-ykfvbypo	345	3	significance	significance	NN
cord-006664-ykfvbypo	345	4	of	of	IN
cord-006664-ykfvbypo	345	5	these	these	DT
cord-006664-ykfvbypo	345	6	observations	observation	NNS
cord-006664-ykfvbypo	345	7	is	be	VBZ
cord-006664-ykfvbypo	345	8	that	that	IN
cord-006664-ykfvbypo	345	9	if	if	IN
cord-006664-ykfvbypo	345	10	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	345	11	can	can	MD
cord-006664-ykfvbypo	345	12	be	be	VB
cord-006664-ykfvbypo	345	13	upregulated	upregulate	VBN
cord-006664-ykfvbypo	345	14	within	within	IN
cord-006664-ykfvbypo	345	15	these	these	DT
cord-006664-ykfvbypo	345	16	lesions	lesion	NNS
cord-006664-ykfvbypo	345	17	,	,	,
cord-006664-ykfvbypo	345	18	then	then	RB
cord-006664-ykfvbypo	345	19	the	the	DT
cord-006664-ykfvbypo	345	20	homeostatic	homeostatic	JJ
cord-006664-ykfvbypo	345	21	mechanisms	mechanism	NNS
cord-006664-ykfvbypo	345	22	will	will	MD
cord-006664-ykfvbypo	345	23	dampen	dampen	VB
cord-006664-ykfvbypo	345	24	down	down	RP
cord-006664-ykfvbypo	345	25	the	the	DT
cord-006664-ykfvbypo	345	26	excessive	excessive	JJ
cord-006664-ykfvbypo	345	27	proliferation	proliferation	NN
cord-006664-ykfvbypo	345	28	of	of	IN
cord-006664-ykfvbypo	345	29	smooth	smooth	JJ
cord-006664-ykfvbypo	345	30	muscle	muscle	NN
cord-006664-ykfvbypo	345	31	cells	cell	NNS
cord-006664-ykfvbypo	345	32	.	.	.
cord-006664-ykfvbypo	346	1	Gene	gene	NN
cord-006664-ykfvbypo	346	2	therapy	therapy	NN
cord-006664-ykfvbypo	346	3	delivering	deliver	VBG
cord-006664-ykfvbypo	346	4	the	the	DT
cord-006664-ykfvbypo	346	5	thymidine	thymidine	NN
cord-006664-ykfvbypo	346	6	kinase	kinase	NN
cord-006664-ykfvbypo	346	7	gene	gene	NN
cord-006664-ykfvbypo	346	8	via	via	IN
cord-006664-ykfvbypo	346	9	an	an	DT
cord-006664-ykfvbypo	346	10	adenoviral	adenoviral	JJ
cord-006664-ykfvbypo	346	11	vector	vector	NN
cord-006664-ykfvbypo	346	12	has	have	VBZ
cord-006664-ykfvbypo	346	13	been	be	VBN
cord-006664-ykfvbypo	346	14	successfully	successfully	RB
cord-006664-ykfvbypo	346	15	used	use	VBN
cord-006664-ykfvbypo	346	16	to	to	TO
cord-006664-ykfvbypo	346	17	reduce	reduce	VB
cord-006664-ykfvbypo	346	18	restenosis	restenosis	NN
cord-006664-ykfvbypo	346	19	after	after	IN
cord-006664-ykfvbypo	346	20	angioplasty	angioplasty	NN
cord-006664-ykfvbypo	346	21	in	in	IN
cord-006664-ykfvbypo	346	22	an	an	DT
cord-006664-ykfvbypo	346	23	atheromatous	atheromatous	JJ
cord-006664-ykfvbypo	346	24	rabbit	rabbit	NN
cord-006664-ykfvbypo	346	25	model	model	NN
cord-006664-ykfvbypo	346	26	by	by	IN
cord-006664-ykfvbypo	346	27	inducing	induce	VBG
cord-006664-ykfvbypo	346	28	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	346	29	of	of	IN
cord-006664-ykfvbypo	346	30	smooth	smooth	JJ
cord-006664-ykfvbypo	346	31	muscle	muscle	NN
cord-006664-ykfvbypo	346	32	cells	cell	NNS
cord-006664-ykfvbypo	346	33	.	.	.
cord-006664-ykfvbypo	346	34	"	"	''
cord-006664-ykfvbypo	347	1	"	"	``
cord-006664-ykfvbypo	347	2	There	there	EX
cord-006664-ykfvbypo	347	3	is	be	VBZ
cord-006664-ykfvbypo	347	4	now	now	RB
cord-006664-ykfvbypo	347	5	clear	clear	JJ
cord-006664-ykfvbypo	347	6	evidence	evidence	NN
cord-006664-ykfvbypo	347	7	that	that	IN
cord-006664-ykfvbypo	347	8	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	347	9	plays	play	VBZ
cord-006664-ykfvbypo	347	10	a	a	DT
cord-006664-ykfvbypo	347	11	key	key	JJ
cord-006664-ykfvbypo	347	12	role	role	NN
cord-006664-ykfvbypo	347	13	in	in	IN
cord-006664-ykfvbypo	347	14	the	the	DT
cord-006664-ykfvbypo	347	15	pathogenesis	pathogenesis	NN
cord-006664-ykfvbypo	347	16	of	of	IN
cord-006664-ykfvbypo	347	17	cardiovascular	cardiovascular	JJ
cord-006664-ykfvbypo	347	18	disease	disease	NN
cord-006664-ykfvbypo	347	19	.	.	.
cord-006664-ykfvbypo	348	1	Its	-PRON-	PRP$
cord-006664-ykfvbypo	348	2	effects	effect	NNS
cord-006664-ykfvbypo	348	3	range	range	VBP
cord-006664-ykfvbypo	348	4	from	from	IN
cord-006664-ykfvbypo	348	5	reduced	reduce	VBN
cord-006664-ykfvbypo	348	6	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	348	7	contributing	contribute	VBG
cord-006664-ykfvbypo	348	8	to	to	IN
cord-006664-ykfvbypo	348	9	neointimal	neointimal	JJ
cord-006664-ykfvbypo	348	10	hyperplasia	hyperplasia	NN
cord-006664-ykfvbypo	348	11	to	to	IN
cord-006664-ykfvbypo	348	12	excessive	excessive	JJ
cord-006664-ykfvbypo	348	13	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	348	14	inducing	induce	VBG
cord-006664-ykfvbypo	348	15	cardiac	cardiac	JJ
cord-006664-ykfvbypo	348	16	failure	failure	NN
cord-006664-ykfvbypo	348	17	.	.	.
cord-006664-ykfvbypo	349	1	The	the	DT
cord-006664-ykfvbypo	349	2	process	process	NN
cord-006664-ykfvbypo	349	3	of	of	IN
cord-006664-ykfvbypo	349	4	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	349	5	may	may	MD
cord-006664-ykfvbypo	349	6	be	be	VB
cord-006664-ykfvbypo	349	7	modulated	modulate	VBN
cord-006664-ykfvbypo	349	8	to	to	TO
cord-006664-ykfvbypo	349	9	attenuate	attenuate	VB
cord-006664-ykfvbypo	349	10	,	,	,
cord-006664-ykfvbypo	349	11	delay	delay	VB
cord-006664-ykfvbypo	349	12	,	,	,
cord-006664-ykfvbypo	349	13	avoid	avoid	VB
cord-006664-ykfvbypo	349	14	or	or	CC
cord-006664-ykfvbypo	349	15	precipitate	precipitate	VB
cord-006664-ykfvbypo	349	16	cell	cell	NN
cord-006664-ykfvbypo	349	17	death	death	NN
cord-006664-ykfvbypo	349	18	.	.	.
cord-006664-ykfvbypo	350	1	These	these	DT
cord-006664-ykfvbypo	350	2	modulations	modulation	NNS
cord-006664-ykfvbypo	350	3	are	be	VBP
cord-006664-ykfvbypo	350	4	used	use	VBN
cord-006664-ykfvbypo	350	5	by	by	IN
cord-006664-ykfvbypo	350	6	neoplastic	neoplastic	JJ
cord-006664-ykfvbypo	350	7	and	and	CC
cord-006664-ykfvbypo	350	8	viral	viral	JJ
cord-006664-ykfvbypo	350	9	infected	infected	JJ
cord-006664-ykfvbypo	350	10	cells	cell	NNS
cord-006664-ykfvbypo	350	11	to	to	TO
cord-006664-ykfvbypo	350	12	promote	promote	VB
cord-006664-ykfvbypo	350	13	their	-PRON-	PRP$
cord-006664-ykfvbypo	350	14	own	own	JJ
cord-006664-ykfvbypo	350	15	survival	survival	NN
cord-006664-ykfvbypo	350	16	.	.	.
cord-006664-ykfvbypo	351	1	However	however	RB
cord-006664-ykfvbypo	351	2	,	,	,
cord-006664-ykfvbypo	351	3	in	in	IN
cord-006664-ykfvbypo	351	4	the	the	DT
cord-006664-ykfvbypo	351	5	context	context	NN
cord-006664-ykfvbypo	351	6	of	of	IN
cord-006664-ykfvbypo	351	7	cardiovascular	cardiovascular	JJ
cord-006664-ykfvbypo	351	8	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	351	9	cell	cell	NN
cord-006664-ykfvbypo	351	10	-death	-death	CD
cord-006664-ykfvbypo	351	11	,	,	,
cord-006664-ykfvbypo	351	12	similar	similar	JJ
cord-006664-ykfvbypo	351	13	manipulations	manipulation	NNS
cord-006664-ykfvbypo	351	14	have	have	VBP
cord-006664-ykfvbypo	351	15	the	the	DT
cord-006664-ykfvbypo	351	16	potential	potential	NN
cord-006664-ykfvbypo	351	17	to	to	TO
cord-006664-ykfvbypo	351	18	be	be	VB
cord-006664-ykfvbypo	351	19	used	use	VBN
cord-006664-ykfvbypo	351	20	to	to	TO
cord-006664-ykfvbypo	351	21	induce	induce	VB
cord-006664-ykfvbypo	351	22	favourable	favourable	JJ
cord-006664-ykfvbypo	351	23	clinical	clinical	JJ
cord-006664-ykfvbypo	351	24	outcomes	outcome	NNS
cord-006664-ykfvbypo	351	25	.	.	.
cord-006664-ykfvbypo	352	1	Genetic	genetic	JJ
cord-006664-ykfvbypo	352	2	transfers	transfer	NNS
cord-006664-ykfvbypo	352	3	of	of	IN
cord-006664-ykfvbypo	352	4	particular	particular	JJ
cord-006664-ykfvbypo	352	5	cellular	cellular	JJ
cord-006664-ykfvbypo	352	6	profiles	profile	NNS
cord-006664-ykfvbypo	352	7	of	of	IN
cord-006664-ykfvbypo	352	8	proto	proto	JJ
cord-006664-ykfvbypo	352	9	-	-	HYPH
cord-006664-ykfvbypo	352	10	oncogene	oncogene	NN
cord-006664-ykfvbypo	352	11	expression	expression	NN
cord-006664-ykfvbypo	352	12	,	,	,
cord-006664-ykfvbypo	352	13	such	such	JJ
cord-006664-ykfvbypo	352	14	as	as	IN
cord-006664-ykfvbypo	352	15	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	352	16	and	and	CC
cord-006664-ykfvbypo	352	17	p53	p53	NN
cord-006664-ykfvbypo	352	18	,	,	,
cord-006664-ykfvbypo	352	19	hold	hold	VBP
cord-006664-ykfvbypo	352	20	the	the	DT
cord-006664-ykfvbypo	352	21	potential	potential	NN
cord-006664-ykfvbypo	352	22	to	to	TO
cord-006664-ykfvbypo	352	23	suppress	suppress	VB
cord-006664-ykfvbypo	352	24	undesirable	undesirable	JJ
cord-006664-ykfvbypo	352	25	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	352	26	in	in	IN
cord-006664-ykfvbypo	352	27	cardiac	cardiac	JJ
cord-006664-ykfvbypo	352	28	ischaemia	ischaemia	NN
cord-006664-ykfvbypo	352	29	or	or	CC
cord-006664-ykfvbypo	352	30	to	to	TO
cord-006664-ykfvbypo	352	31	beneficially	beneficially	RB
cord-006664-ykfvbypo	352	32	promote	promote	VB
cord-006664-ykfvbypo	352	33	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	352	34	in	in	IN
cord-006664-ykfvbypo	352	35	neointimal	neointimal	JJ
cord-006664-ykfvbypo	352	36	hyperplasia	hyperplasia	NN
cord-006664-ykfvbypo	352	37	.	.	.
cord-006664-ykfvbypo	353	1	The	the	DT
cord-006664-ykfvbypo	353	2	inflammatory	inflammatory	JJ
cord-006664-ykfvbypo	353	3	response	response	NN
cord-006664-ykfvbypo	353	4	is	be	VBZ
cord-006664-ykfvbypo	353	5	a	a	DT
cord-006664-ykfvbypo	353	6	dynamic	dynamic	JJ
cord-006664-ykfvbypo	353	7	process	process	NN
cord-006664-ykfvbypo	353	8	and	and	CC
cord-006664-ykfvbypo	353	9	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	353	10	is	be	VBZ
cord-006664-ykfvbypo	353	11	recognised	recognise	VBN
cord-006664-ykfvbypo	353	12	as	as	IN
cord-006664-ykfvbypo	353	13	being	be	VBG
cord-006664-ykfvbypo	353	14	a	a	DT
cord-006664-ykfvbypo	353	15	key	key	JJ
cord-006664-ykfvbypo	353	16	element	element	NN
cord-006664-ykfvbypo	353	17	in	in	IN
cord-006664-ykfvbypo	353	18	this	this	DT
cord-006664-ykfvbypo	353	19	continuum	continuum	NN
cord-006664-ykfvbypo	353	20	.	.	.
cord-006664-ykfvbypo	354	1	It	-PRON-	PRP
cord-006664-ykfvbypo	354	2	occurs	occur	VBZ
cord-006664-ykfvbypo	354	3	early	early	JJ
cord-006664-ykfvbypo	354	4	"	"	``
cord-006664-ykfvbypo	354	5	°	°	NN
cord-006664-ykfvbypo	354	6	and	and	CC
cord-006664-ykfvbypo	354	7	late	late	JJ
cord-006664-ykfvbypo	354	8	"	"	''
cord-006664-ykfvbypo	354	9	,	,	,
cord-006664-ykfvbypo	354	10	"	"	''
cord-006664-ykfvbypo	354	11	in	in	IN
cord-006664-ykfvbypo	354	12	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	354	13	as	as	IN
cord-006664-ykfvbypo	354	14	a	a	DT
cord-006664-ykfvbypo	354	15	part	part	NN
cord-006664-ykfvbypo	354	16	of	of	IN
cord-006664-ykfvbypo	354	17	IR	IR	NNP
cord-006664-ykfvbypo	354	18	injury	injury	NN
cord-006664-ykfvbypo	354	19	.	.	.
cord-006664-ykfvbypo	355	1	The	the	DT
cord-006664-ykfvbypo	355	2	mechanisms	mechanism	NNS
cord-006664-ykfvbypo	355	3	involved	involve	VBN
cord-006664-ykfvbypo	355	4	in	in	IN
cord-006664-ykfvbypo	355	5	these	these	DT
cord-006664-ykfvbypo	355	6	processes	process	NNS
cord-006664-ykfvbypo	355	7	are	be	VBP
cord-006664-ykfvbypo	355	8	gradually	gradually	RB
cord-006664-ykfvbypo	355	9	being	be	VBG
cord-006664-ykfvbypo	355	10	elucidated	elucidate	VBN
cord-006664-ykfvbypo	355	11	in	in	IN
cord-006664-ykfvbypo	355	12	the	the	DT
cord-006664-ykfvbypo	355	13	myocardium	myocardium	NN
cord-006664-ykfvbypo	355	14	and	and	CC
cord-006664-ykfvbypo	355	15	endothelium	endothelium	NN
cord-006664-ykfvbypo	355	16	.	.	.
cord-006664-ykfvbypo	355	17	'	'	''
cord-006664-ykfvbypo	356	1	42	42	CD
cord-006664-ykfvbypo	356	2	'	'	''
cord-006664-ykfvbypo	357	1	In	in	IN
cord-006664-ykfvbypo	357	2	the	the	DT
cord-006664-ykfvbypo	357	3	myocardium	myocardium	NN
cord-006664-ykfvbypo	357	4	and	and	CC
cord-006664-ykfvbypo	357	5	vascular	vascular	JJ
cord-006664-ykfvbypo	357	6	endothelium	endothelium	NN
cord-006664-ykfvbypo	357	7	,	,	,
cord-006664-ykfvbypo	357	8	reactive	reactive	JJ
cord-006664-ykfvbypo	357	9	oxygen	oxygen	NN
cord-006664-ykfvbypo	357	10	species	specie	NNS
cord-006664-ykfvbypo	357	11	,	,	,
cord-006664-ykfvbypo	357	12	inflammatory	inflammatory	JJ
cord-006664-ykfvbypo	357	13	cytokines	cytokine	NNS
cord-006664-ykfvbypo	357	14	,	,	,
cord-006664-ykfvbypo	357	15	NO	no	UH
cord-006664-ykfvbypo	357	16	,	,	,
cord-006664-ykfvbypo	357	17	hypoxia	hypoxia	NN
cord-006664-ykfvbypo	357	18	,	,	,
cord-006664-ykfvbypo	357	19	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	357	20	and	and	CC
cord-006664-ykfvbypo	357	21	mechanical	mechanical	JJ
cord-006664-ykfvbypo	357	22	stretch	stretch	NN
cord-006664-ykfvbypo	357	23	exert	exert	VBP
cord-006664-ykfvbypo	357	24	pro	pro	JJ
cord-006664-ykfvbypo	357	25	-	-	JJ
cord-006664-ykfvbypo	357	26	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	357	27	influences	influence	NNS
cord-006664-ykfvbypo	357	28	upon	upon	IN
cord-006664-ykfvbypo	357	29	cells	cell	NNS
cord-006664-ykfvbypo	357	30	.	.	.
cord-006664-ykfvbypo	358	1	The	the	DT
cord-006664-ykfvbypo	358	2	clinical	clinical	JJ
cord-006664-ykfvbypo	358	3	syndromes	syndrome	NNS
cord-006664-ykfvbypo	358	4	produced	produce	VBN
cord-006664-ykfvbypo	358	5	by	by	IN
cord-006664-ykfvbypo	358	6	these	these	DT
cord-006664-ykfvbypo	358	7	influences	influence	NNS
cord-006664-ykfvbypo	358	8	have	have	VBP
cord-006664-ykfvbypo	358	9	established	establish	VBN
cord-006664-ykfvbypo	358	10	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	358	11	contributions	contribution	NNS
cord-006664-ykfvbypo	358	12	to	to	IN
cord-006664-ykfvbypo	358	13	their	-PRON-	PRP$
cord-006664-ykfvbypo	358	14	pathogenesis	pathogenesis	NN
cord-006664-ykfvbypo	358	15	and	and	CC
cord-006664-ykfvbypo	358	16	significance	significance	NN
cord-006664-ykfvbypo	358	17	.	.	.
cord-006664-ykfvbypo	359	1	The	the	DT
cord-006664-ykfvbypo	359	2	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	359	3	cpmponent	cpmponent	NN
cord-006664-ykfvbypo	359	4	contributing	contribute	VBG
cord-006664-ykfvbypo	359	5	to	to	IN
cord-006664-ykfvbypo	359	6	these	these	DT
cord-006664-ykfvbypo	359	7	disease	disease	NN
cord-006664-ykfvbypo	359	8	processes	process	NNS
cord-006664-ykfvbypo	359	9	is	be	VBZ
cord-006664-ykfvbypo	359	10	potentially	potentially	RB
cord-006664-ykfvbypo	359	11	amenable	amenable	JJ
cord-006664-ykfvbypo	359	12	to	to	IN
cord-006664-ykfvbypo	359	13	beneficial	beneficial	JJ
cord-006664-ykfvbypo	359	14	therapeutic	therapeutic	JJ
cord-006664-ykfvbypo	359	15	manipulation	manipulation	NN
cord-006664-ykfvbypo	359	16	.	.	.
cord-006664-ykfvbypo	360	1	This	this	DT
cord-006664-ykfvbypo	360	2	study	study	NN
cord-006664-ykfvbypo	360	3	was	be	VBD
cord-006664-ykfvbypo	360	4	funded	fund	VBN
cord-006664-ykfvbypo	360	5	by	by	IN
cord-006664-ykfvbypo	360	6	a	a	DT
cord-006664-ykfvbypo	360	7	Health	Health	NNP
cord-006664-ykfvbypo	360	8	Research	Research	NNP
cord-006664-ykfvbypo	360	9	Board	Board	NNP
cord-006664-ykfvbypo	360	10	clinical	clinical	JJ
cord-006664-ykfvbypo	360	11	research	research	NN
cord-006664-ykfvbypo	360	12	fellowship	fellowship	NN
cord-006664-ykfvbypo	360	13	and	and	CC
cord-006664-ykfvbypo	360	14	the	the	DT
cord-006664-ykfvbypo	360	15	North	North	NNP
cord-006664-ykfvbypo	360	16	-	-	HYPH
cord-006664-ykfvbypo	360	17	Eastern	Eastern	NNP
cord-006664-ykfvbypo	360	18	Health	Health	NNP
cord-006664-ykfvbypo	360	19	Board	Board	NNP
cord-006664-ykfvbypo	360	20	.	.	.
cord-006664-ykfvbypo	361	1	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	361	2	:	:	:
cord-006664-ykfvbypo	361	3	a	a	DT
cord-006664-ykfvbypo	361	4	basic	basic	JJ
cord-006664-ykfvbypo	361	5	biological	biological	JJ
cord-006664-ykfvbypo	361	6	phenomenon	phenomenon	NN
cord-006664-ykfvbypo	361	7	with	with	IN
cord-006664-ykfvbypo	361	8	wide	wide	JJ
cord-006664-ykfvbypo	361	9	ranging	range	VBG
cord-006664-ykfvbypo	361	10	implications	implication	NNS
cord-006664-ykfvbypo	361	11	in	in	IN
cord-006664-ykfvbypo	361	12	tissue	tissue	NN
cord-006664-ykfvbypo	361	13	cell	cell	NN
cord-006664-ykfvbypo	361	14	kinetics	kinetics	NN
cord-006664-ykfvbypo	361	15	Stretch	Stretch	NNP
cord-006664-ykfvbypo	361	16	induced	induce	VBN
cord-006664-ykfvbypo	361	17	programmed	program	VBD
cord-006664-ykfvbypo	361	18	myocyte	myocyte	NNP
cord-006664-ykfvbypo	361	19	cell	cell	NN
cord-006664-ykfvbypo	361	20	death	death	NN
cord-006664-ykfvbypo	362	1	The	the	DT
cord-006664-ykfvbypo	362	2	cellular	cellular	JJ
cord-006664-ykfvbypo	362	3	basis	basis	NN
cord-006664-ykfvbypo	362	4	of	of	IN
cord-006664-ykfvbypo	362	5	dilated	dilated	JJ
cord-006664-ykfvbypo	362	6	cardiomyopathy	cardiomyopathy	NN
cord-006664-ykfvbypo	362	7	in	in	IN
cord-006664-ykfvbypo	363	1	humans	human	NNS
cord-006664-ykfvbypo	363	2	Acute	acute	JJ
cord-006664-ykfvbypo	364	1	myocardial	myocardial	JJ
cord-006664-ykfvbypo	364	2	infarction	infarction	NN
cord-006664-ykfvbypo	364	3	in	in	IN
cord-006664-ykfvbypo	364	4	humans	human	NNS
cord-006664-ykfvbypo	364	5	is	be	VBZ
cord-006664-ykfvbypo	364	6	associated	associate	VBN
cord-006664-ykfvbypo	364	7	with	with	IN
cord-006664-ykfvbypo	364	8	activation	activation	NN
cord-006664-ykfvbypo	364	9	of	of	IN
cord-006664-ykfvbypo	364	10	programmed	program	VBN
cord-006664-ykfvbypo	364	11	myocyte	myocyte	NNP
cord-006664-ykfvbypo	364	12	cell	cell	NN
cord-006664-ykfvbypo	364	13	death	death	NN
cord-006664-ykfvbypo	364	14	in	in	IN
cord-006664-ykfvbypo	364	15	the	the	DT
cord-006664-ykfvbypo	364	16	surviving	survive	VBG
cord-006664-ykfvbypo	364	17	portion	portion	NN
cord-006664-ykfvbypo	364	18	of	of	IN
cord-006664-ykfvbypo	364	19	the	the	DT
cord-006664-ykfvbypo	364	20	heart	heart	NN
cord-006664-ykfvbypo	364	21	Apoptosis	Apoptosis	NNP
cord-006664-ykfvbypo	364	22	:	:	:
cord-006664-ykfvbypo	364	23	an	an	DT
cord-006664-ykfvbypo	364	24	overview	overview	NN
cord-006664-ykfvbypo	364	25	Cytological	Cytological	NNP
cord-006664-ykfvbypo	364	26	and	and	CC
cord-006664-ykfvbypo	364	27	cytochemical	cytochemical	NNP
cord-006664-ykfvbypo	364	28	studies	study	NNS
cord-006664-ykfvbypo	364	29	on	on	IN
cord-006664-ykfvbypo	364	30	cell	cell	NN
cord-006664-ykfvbypo	364	31	death	death	NN
cord-006664-ykfvbypo	364	32	and	and	CC
cord-006664-ykfvbypo	364	33	digestion	digestion	NN
cord-006664-ykfvbypo	364	34	in	in	IN
cord-006664-ykfvbypo	364	35	the	the	DT
cord-006664-ykfvbypo	364	36	foetal	foetal	JJ
cord-006664-ykfvbypo	364	37	rat	rat	NN
cord-006664-ykfvbypo	364	38	foot	foot	NN
cord-006664-ykfvbypo	364	39	:	:	:
cord-006664-ykfvbypo	364	40	the	the	DT
cord-006664-ykfvbypo	364	41	role	role	NN
cord-006664-ykfvbypo	364	42	of	of	IN
cord-006664-ykfvbypo	364	43	macrophages	macrophage	NNS
cord-006664-ykfvbypo	364	44	and	and	CC
cord-006664-ykfvbypo	364	45	hydrolytic	hydrolytic	JJ
cord-006664-ykfvbypo	364	46	enzymes	enzyme	NNS
cord-006664-ykfvbypo	364	47	Cell	Cell	NNP
cord-006664-ykfvbypo	364	48	death	death	NN
cord-006664-ykfvbypo	364	49	by	by	IN
cord-006664-ykfvbypo	364	50	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	364	51	and	and	CC
cord-006664-ykfvbypo	364	52	its	-PRON-	PRP$
cord-006664-ykfvbypo	364	53	protective	protective	JJ
cord-006664-ykfvbypo	364	54	role	role	NN
cord-006664-ykfvbypo	364	55	against	against	IN
cord-006664-ykfvbypo	364	56	disease	disease	NN
cord-006664-ykfvbypo	364	57	Apoptosis	Apoptosis	NNP
cord-006664-ykfvbypo	364	58	and	and	CC
cord-006664-ykfvbypo	364	59	carcinogenesis	carcinogenesis	NN
cord-006664-ykfvbypo	364	60	Programmed	program	VBD
cord-006664-ykfvbypo	364	61	cell	cell	NN
cord-006664-ykfvbypo	364	62	death	death	NN
cord-006664-ykfvbypo	364	63	:	:	:
cord-006664-ykfvbypo	365	1	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	365	2	and	and	CC
cord-006664-ykfvbypo	365	3	oncogenesis	oncogenesis	NN
cord-006664-ykfvbypo	366	1	The	the	DT
cord-006664-ykfvbypo	366	2	role	role	NN
cord-006664-ykfvbypo	366	3	of	of	IN
cord-006664-ykfvbypo	366	4	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	366	5	in	in	IN
cord-006664-ykfvbypo	366	6	the	the	DT
cord-006664-ykfvbypo	366	7	response	response	NN
cord-006664-ykfvbypo	366	8	of	of	IN
cord-006664-ykfvbypo	366	9	cells	cell	NNS
cord-006664-ykfvbypo	366	10	and	and	CC
cord-006664-ykfvbypo	366	11	tumours	tumour	NNS
cord-006664-ykfvbypo	366	12	to	to	TO
cord-006664-ykfvbypo	366	13	mild	mild	JJ
cord-006664-ykfvbypo	366	14	hyperthermia	hyperthermia	NN
cord-006664-ykfvbypo	366	15	Programmed	program	VBN
cord-006664-ykfvbypo	366	16	cell	cell	NN
cord-006664-ykfvbypo	366	17	death	death	NN
cord-006664-ykfvbypo	366	18	:	:	:
cord-006664-ykfvbypo	366	19	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	366	20	and	and	CC
cord-006664-ykfvbypo	366	21	oncogenesis	oncogenesis	NN
cord-006664-ykfvbypo	366	22	Activation	activation	NN
cord-006664-ykfvbypo	366	23	of	of	IN
cord-006664-ykfvbypo	366	24	programmed	programmed	JJ
cord-006664-ykfvbypo	366	25	cell	cell	NN
cord-006664-ykfvbypo	366	26	death	death	NN
cord-006664-ykfvbypo	366	27	(	(	-LRB-
cord-006664-ykfvbypo	366	28	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	366	29	)	)	-RRB-
cord-006664-ykfvbypo	366	30	by	by	IN
cord-006664-ykfvbypo	366	31	cisplatin	cisplatin	NN
cord-006664-ykfvbypo	366	32	,	,	,
cord-006664-ykfvbypo	366	33	other	other	JJ
cord-006664-ykfvbypo	366	34	anti	anti	JJ
cord-006664-ykfvbypo	366	35	-	-	JJ
cord-006664-ykfvbypo	366	36	cancer	cancer	JJ
cord-006664-ykfvbypo	366	37	drugs	drug	NNS
cord-006664-ykfvbypo	366	38	and	and	CC
cord-006664-ykfvbypo	366	39	hyperthermia	hyperthermia	NN
cord-006664-ykfvbypo	367	1	The	the	DT
cord-006664-ykfvbypo	367	2	importance	importance	NN
cord-006664-ykfvbypo	367	3	of	of	IN
cord-006664-ykfvbypo	367	4	oxidative	oxidative	JJ
cord-006664-ykfvbypo	367	5	stress	stress	NN
cord-006664-ykfvbypo	367	6	in	in	IN
cord-006664-ykfvbypo	367	7	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	367	8	Reperfusion	reperfusion	NN
cord-006664-ykfvbypo	367	9	injury	injury	NN
cord-006664-ykfvbypo	367	10	induces	induce	VBZ
cord-006664-ykfvbypo	367	11	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	367	12	in	in	IN
cord-006664-ykfvbypo	367	13	rabbit	rabbit	NN
cord-006664-ykfvbypo	367	14	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	367	15	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	367	16	in	in	IN
cord-006664-ykfvbypo	367	17	the	the	DT
cord-006664-ykfvbypo	367	18	heart	heart	NN
cord-006664-ykfvbypo	367	19	Apoptosis	Apoptosis	NNP
cord-006664-ykfvbypo	367	20	and	and	CC
cord-006664-ykfvbypo	367	21	the	the	DT
cord-006664-ykfvbypo	367	22	failing	fail	VBG
cord-006664-ykfvbypo	367	23	human	human	JJ
cord-006664-ykfvbypo	367	24	heart	heart	NN
cord-006664-ykfvbypo	367	25	Myocyte	Myocyte	NNP
cord-006664-ykfvbypo	367	26	nuclear	nuclear	JJ
cord-006664-ykfvbypo	367	27	and	and	CC
cord-006664-ykfvbypo	367	28	possible	possible	JJ
cord-006664-ykfvbypo	367	29	cellular	cellular	JJ
cord-006664-ykfvbypo	367	30	hyperplasia	hyperplasia	NN
cord-006664-ykfvbypo	367	31	contribute	contribute	VB
cord-006664-ykfvbypo	367	32	to	to	IN
cord-006664-ykfvbypo	367	33	ventricular	ventricular	JJ
cord-006664-ykfvbypo	367	34	remodeling	remodeling	NN
cord-006664-ykfvbypo	367	35	in	in	IN
cord-006664-ykfvbypo	367	36	the	the	DT
cord-006664-ykfvbypo	367	37	hypertrophic	hypertrophic	JJ
cord-006664-ykfvbypo	367	38	senescent	senescent	JJ
cord-006664-ykfvbypo	367	39	heart	heart	NN
cord-006664-ykfvbypo	367	40	in	in	IN
cord-006664-ykfvbypo	367	41	humans	human	NNS
cord-006664-ykfvbypo	367	42	Apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	367	43	and	and	CC
cord-006664-ykfvbypo	367	44	necrotic	necrotic	JJ
cord-006664-ykfvbypo	367	45	cell	cell	NN
cord-006664-ykfvbypo	367	46	deaths	death	NNS
cord-006664-ykfvbypo	368	1	are	be	VBP
cord-006664-ykfvbypo	368	2	independent	independent	JJ
cord-006664-ykfvbypo	368	3	contributing	contribute	VBG
cord-006664-ykfvbypo	368	4	variables	variable	NNS
cord-006664-ykfvbypo	368	5	of	of	IN
cord-006664-ykfvbypo	368	6	infarct	infarct	NN
cord-006664-ykfvbypo	368	7	size	size	NN
cord-006664-ykfvbypo	368	8	in	in	IN
cord-006664-ykfvbypo	368	9	rats	rat	NNS
cord-006664-ykfvbypo	369	1	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	369	2	is	be	VBZ
cord-006664-ykfvbypo	369	3	abundant	abundant	JJ
cord-006664-ykfvbypo	369	4	in	in	IN
cord-006664-ykfvbypo	369	5	human	human	JJ
cord-006664-ykfvbypo	369	6	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	369	7	lesions	lesion	NNS
cord-006664-ykfvbypo	369	8	especially	especially	RB
cord-006664-ykfvbypo	369	9	in	in	IN
cord-006664-ykfvbypo	369	10	inflammatory	inflammatory	JJ
cord-006664-ykfvbypo	369	11	cells	cell	NNS
cord-006664-ykfvbypo	369	12	and	and	CC
cord-006664-ykfvbypo	369	13	may	may	MD
cord-006664-ykfvbypo	369	14	contribute	contribute	VB
cord-006664-ykfvbypo	369	15	to	to	IN
cord-006664-ykfvbypo	369	16	the	the	DT
cord-006664-ykfvbypo	369	17	accumulation	accumulation	NN
cord-006664-ykfvbypo	369	18	of	of	IN
cord-006664-ykfvbypo	369	19	gruel	gruel	NN
cord-006664-ykfvbypo	369	20	and	and	CC
cord-006664-ykfvbypo	369	21	plaque	plaque	NN
cord-006664-ykfvbypo	369	22	instability	instability	NN
cord-006664-ykfvbypo	369	23	Apoptosis	Apoptosis	NNP
cord-006664-ykfvbypo	369	24	in	in	IN
cord-006664-ykfvbypo	369	25	human	human	JJ
cord-006664-ykfvbypo	369	26	atherosclerosis	atherosclerosis	NN
cord-006664-ykfvbypo	369	27	and	and	CC
cord-006664-ykfvbypo	369	28	restenosis	restenosis	NN
cord-006664-ykfvbypo	369	29	Apoptosis	Apoptosis	NNP
cord-006664-ykfvbypo	369	30	in	in	IN
cord-006664-ykfvbypo	369	31	the	the	DT
cord-006664-ykfvbypo	369	32	infarcted	infarcted	JJ
cord-006664-ykfvbypo	369	33	human	human	JJ
cord-006664-ykfvbypo	369	34	heart	heart	NN
cord-006664-ykfvbypo	369	35	Apoptosis	Apoptosis	NNP
cord-006664-ykfvbypo	369	36	;	;	:
cord-006664-ykfvbypo	369	37	The	the	DT
cord-006664-ykfvbypo	369	38	role	role	NN
cord-006664-ykfvbypo	369	39	of	of	IN
cord-006664-ykfvbypo	369	40	the	the	DT
cord-006664-ykfvbypo	369	41	endonuclease	endonuclease	NN
cord-006664-ykfvbypo	369	42	Tumour	tumour	NN
cord-006664-ykfvbypo	369	43	necrosis	necrosis	NN
cord-006664-ykfvbypo	369	44	factor	factor	NN
cord-006664-ykfvbypo	369	45	alpha	alpha	NN
cord-006664-ykfvbypo	369	46	induced	induce	VBN
cord-006664-ykfvbypo	369	47	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	369	48	in	in	IN
cord-006664-ykfvbypo	369	49	cardiac	cardiac	JJ
cord-006664-ykfvbypo	369	50	myocytes	myocyte	NNS
cord-006664-ykfvbypo	370	1	Microelectrophoretic	microelectrophoretic	JJ
cord-006664-ykfvbypo	370	2	study	study	NN
cord-006664-ykfvbypo	370	3	of	of	IN
cord-006664-ykfvbypo	370	4	radiation	radiation	NN
cord-006664-ykfvbypo	370	5	induced	induce	VBN
cord-006664-ykfvbypo	370	6	DNA	dna	NN
cord-006664-ykfvbypo	370	7	damage	damage	NN
cord-006664-ykfvbypo	370	8	in	in	IN
cord-006664-ykfvbypo	370	9	mammalian	mammalian	JJ
cord-006664-ykfvbypo	370	10	cells	cell	NNS
cord-006664-ykfvbypo	371	1	The	the	DT
cord-006664-ykfvbypo	371	2	comet	comet	JJ
cord-006664-ykfvbypo	371	3	assay	assay	NN
cord-006664-ykfvbypo	371	4	:	:	:
cord-006664-ykfvbypo	371	5	a	a	DT
cord-006664-ykfvbypo	371	6	comprehensive	comprehensive	JJ
cord-006664-ykfvbypo	371	7	review	review	NN
cord-006664-ykfvbypo	372	1	The	the	DT
cord-006664-ykfvbypo	372	2	cell	cell	NN
cord-006664-ykfvbypo	372	3	cycle	cycle	NN
cord-006664-ykfvbypo	372	4	related	relate	VBD
cord-006664-ykfvbypo	372	5	differences	difference	NNS
cord-006664-ykfvbypo	372	6	in	in	IN
cord-006664-ykfvbypo	372	7	susceptibility	susceptibility	NN
cord-006664-ykfvbypo	372	8	of	of	IN
cord-006664-ykfvbypo	372	9	HL-60	HL-60	NNP
cord-006664-ykfvbypo	372	10	cells	cell	NNS
cord-006664-ykfvbypo	372	11	to	to	IN
cord-006664-ykfvbypo	372	12	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	372	13	induced	induce	VBN
cord-006664-ykfvbypo	372	14	by	by	IN
cord-006664-ykfvbypo	372	15	various	various	JJ
cord-006664-ykfvbypo	372	16	antitumor	antitumor	JJ
cord-006664-ykfvbypo	372	17	agents	agent	NNS
cord-006664-ykfvbypo	372	18	Differentiation	differentiation	NN
cord-006664-ykfvbypo	372	19	between	between	IN
cord-006664-ykfvbypo	372	20	cellular	cellular	JJ
cord-006664-ykfvbypo	372	21	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	372	22	and	and	CC
cord-006664-ykfvbypo	372	23	necrosis	necrosis	NN
cord-006664-ykfvbypo	372	24	by	by	IN
cord-006664-ykfvbypo	372	25	the	the	DT
cord-006664-ykfvbypo	372	26	combined	combine	VBN
cord-006664-ykfvbypo	372	27	use	use	NN
cord-006664-ykfvbypo	372	28	of	of	IN
cord-006664-ykfvbypo	372	29	in	in	IN
cord-006664-ykfvbypo	372	30	situ	situ	NN
cord-006664-ykfvbypo	372	31	tailing	tailing	NN
cord-006664-ykfvbypo	372	32	and	and	CC
cord-006664-ykfvbypo	372	33	nick	nick	NNP
cord-006664-ykfvbypo	372	34	translation	translation	NN
cord-006664-ykfvbypo	372	35	techniques	technique	VBZ
cord-006664-ykfvbypo	372	36	Events	event	NNS
cord-006664-ykfvbypo	372	37	in	in	IN
cord-006664-ykfvbypo	372	38	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	372	39	.	.	.
cord-006664-ykfvbypo	373	1	Acidification	acidification	NN
cord-006664-ykfvbypo	373	2	is	be	VBZ
cord-006664-ykfvbypo	373	3	downstream	downstream	JJ
cord-006664-ykfvbypo	373	4	of	of	IN
cord-006664-ykfvbypo	373	5	protease	protease	NN
cord-006664-ykfvbypo	373	6	activation	activation	NN
cord-006664-ykfvbypo	373	7	and	and	CC
cord-006664-ykfvbypo	373	8	BCL-2	BCL-2	NNP
cord-006664-ykfvbypo	373	9	protection	protection	NN
cord-006664-ykfvbypo	374	1	Preconditioning	preconditioning	NN
cord-006664-ykfvbypo	374	2	protects	protect	VBZ
cord-006664-ykfvbypo	374	3	ischemic	ischemic	JJ
cord-006664-ykfvbypo	374	4	rabbit	rabbit	NN
cord-006664-ykfvbypo	374	5	heart	heart	NN
cord-006664-ykfvbypo	374	6	by	by	IN
cord-006664-ykfvbypo	374	7	protein	protein	NN
cord-006664-ykfvbypo	374	8	kinase	kinase	NN
cord-006664-ykfvbypo	374	9	C	C	NNP
cord-006664-ykfvbypo	374	10	activation	activation	NN
cord-006664-ykfvbypo	374	11	Preconditioning	Preconditioning	NNP
cord-006664-ykfvbypo	374	12	rabbit	rabbit	NN
cord-006664-ykfvbypo	374	13	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	374	14	:	:	:
cord-006664-ykfvbypo	375	1	role	role	NN
cord-006664-ykfvbypo	375	2	of	of	IN
cord-006664-ykfvbypo	375	3	pH	pH	NNP
cord-006664-ykfvbypo	375	4	,	,	,
cord-006664-ykfvbypo	375	5	vacuolar	vacuolar	NNP
cord-006664-ykfvbypo	375	6	proton	proton	NN
cord-006664-ykfvbypo	375	7	ATPase	ATPase	NNP
cord-006664-ykfvbypo	375	8	,	,	,
cord-006664-ykfvbypo	375	9	and	and	CC
cord-006664-ykfvbypo	375	10	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	375	11	Role	role	NN
cord-006664-ykfvbypo	375	12	of	of	IN
cord-006664-ykfvbypo	375	13	translocases	translocase	NNS
cord-006664-ykfvbypo	375	14	in	in	IN
cord-006664-ykfvbypo	375	15	the	the	DT
cord-006664-ykfvbypo	375	16	generation	generation	NN
cord-006664-ykfvbypo	375	17	of	of	IN
cord-006664-ykfvbypo	375	18	phosphatidylserine	phosphatidylserine	NN
cord-006664-ykfvbypo	375	19	asymmetry	asymmetry	NN
cord-006664-ykfvbypo	376	1	Different	different	JJ
cord-006664-ykfvbypo	376	2	populations	population	NNS
cord-006664-ykfvbypo	376	3	of	of	IN
cord-006664-ykfvbypo	376	4	macrophages	macrophage	NNS
cord-006664-ykfvbypo	376	5	use	use	VBP
cord-006664-ykfvbypo	376	6	either	either	CC
cord-006664-ykfvbypo	376	7	the	the	DT
cord-006664-ykfvbypo	376	8	vitronectin	vitronectin	NNP
cord-006664-ykfvbypo	376	9	receptor	receptor	NN
cord-006664-ykfvbypo	376	10	or	or	CC
cord-006664-ykfvbypo	376	11	the	the	DT
cord-006664-ykfvbypo	376	12	phosphatidylserine	phosphatidylserine	NN
cord-006664-ykfvbypo	376	13	receptor	receptor	NN
cord-006664-ykfvbypo	376	14	to	to	TO
cord-006664-ykfvbypo	376	15	recognise	recognise	VB
cord-006664-ykfvbypo	376	16	and	and	CC
cord-006664-ykfvbypo	376	17	remove	remove	VB
cord-006664-ykfvbypo	376	18	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	376	19	cells	cell	NNS
cord-006664-ykfvbypo	376	20	Exposure	exposure	NN
cord-006664-ykfvbypo	376	21	of	of	IN
cord-006664-ykfvbypo	376	22	phosphatidylserine	phosphatidylserine	NN
cord-006664-ykfvbypo	376	23	on	on	IN
cord-006664-ykfvbypo	376	24	the	the	DT
cord-006664-ykfvbypo	376	25	surface	surface	NN
cord-006664-ykfvbypo	376	26	of	of	IN
cord-006664-ykfvbypo	376	27	lymphocytes	lymphocyte	NNS
cord-006664-ykfvbypo	376	28	triggers	trigger	VBZ
cord-006664-ykfvbypo	376	29	specific	specific	JJ
cord-006664-ykfvbypo	376	30	recognition	recognition	NN
cord-006664-ykfvbypo	376	31	and	and	CC
cord-006664-ykfvbypo	376	32	removal	removal	NN
cord-006664-ykfvbypo	376	33	by	by	IN
cord-006664-ykfvbypo	376	34	macrophages	macrophage	NNS
cord-006664-ykfvbypo	376	35	Binding	Binding	NNP
cord-006664-ykfvbypo	376	36	of	of	IN
cord-006664-ykfvbypo	376	37	vascular	vascular	JJ
cord-006664-ykfvbypo	376	38	anticoagulant	anticoagulant	NN
cord-006664-ykfvbypo	376	39	to	to	IN
cord-006664-ykfvbypo	376	40	planar	planar	JJ
cord-006664-ykfvbypo	376	41	phospholipid	phospholipid	NN
cord-006664-ykfvbypo	376	42	bilayers	bilayer	NNS
cord-006664-ykfvbypo	377	1	Thrombin	Thrombin	NNP
cord-006664-ykfvbypo	377	2	generation	generation	NN
cord-006664-ykfvbypo	377	3	by	by	IN
cord-006664-ykfvbypo	377	4	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	377	5	vascular	vascular	JJ
cord-006664-ykfvbypo	377	6	smooth	smooth	JJ
cord-006664-ykfvbypo	377	7	muscle	muscle	NN
cord-006664-ykfvbypo	377	8	cells	cell	NNS
cord-006664-ykfvbypo	377	9	Studies	study	NNS
cord-006664-ykfvbypo	377	10	on	on	IN
cord-006664-ykfvbypo	377	11	cell	cell	NN
cord-006664-ykfvbypo	377	12	agony	agony	NN
cord-006664-ykfvbypo	377	13	and	and	CC
cord-006664-ykfvbypo	377	14	death	death	NN
cord-006664-ykfvbypo	377	15	:	:	:
cord-006664-ykfvbypo	378	1	an	an	DT
cord-006664-ykfvbypo	378	2	attempt	attempt	NN
cord-006664-ykfvbypo	378	3	at	at	IN
cord-006664-ykfvbypo	378	4	classification	classification	NN
cord-006664-ykfvbypo	378	5	Death	death	NN
cord-006664-ykfvbypo	378	6	of	of	IN
cord-006664-ykfvbypo	378	7	a	a	DT
cord-006664-ykfvbypo	378	8	cell	cell	NN
cord-006664-ykfvbypo	378	9	Inflammation	inflammation	NN
cord-006664-ykfvbypo	378	10	in	in	IN
cord-006664-ykfvbypo	378	11	the	the	DT
cord-006664-ykfvbypo	378	12	course	course	NN
cord-006664-ykfvbypo	378	13	of	of	IN
cord-006664-ykfvbypo	378	14	early	early	JJ
cord-006664-ykfvbypo	378	15	myocardial	myocardial	JJ
cord-006664-ykfvbypo	378	16	ischemia	ischemia	NN
cord-006664-ykfvbypo	378	17	Apoptosis	Apoptosis	NNP
cord-006664-ykfvbypo	378	18	in	in	IN
cord-006664-ykfvbypo	378	19	the	the	DT
cord-006664-ykfvbypo	378	20	pathogenesis	pathogenesis	NN
cord-006664-ykfvbypo	378	21	and	and	CC
cord-006664-ykfvbypo	378	22	treatment	treatment	NN
cord-006664-ykfvbypo	378	23	of	of	IN
cord-006664-ykfvbypo	378	24	disease	disease	NN
cord-006664-ykfvbypo	378	25	Apoptosis	Apoptosis	NNP
cord-006664-ykfvbypo	378	26	in	in	IN
cord-006664-ykfvbypo	378	27	myocytes	myocyte	NNS
cord-006664-ykfvbypo	378	28	in	in	IN
cord-006664-ykfvbypo	378	29	end	end	JJ
cord-006664-ykfvbypo	378	30	stage	stage	NN
cord-006664-ykfvbypo	378	31	heart	heart	NN
cord-006664-ykfvbypo	378	32	failure	failure	NN
cord-006664-ykfvbypo	379	1	The	the	DT
cord-006664-ykfvbypo	379	2	ins	in	NNS
cord-006664-ykfvbypo	379	3	and	and	CC
cord-006664-ykfvbypo	379	4	outs	out	NNS
cord-006664-ykfvbypo	379	5	of	of	IN
cord-006664-ykfvbypo	379	6	programmed	programmed	JJ
cord-006664-ykfvbypo	379	7	cell	cell	NN
cord-006664-ykfvbypo	379	8	death	death	NN
cord-006664-ykfvbypo	379	9	during	during	IN
cord-006664-ykfvbypo	379	10	C.	C.	NNP
cord-006664-ykfvbypo	379	11	Elegans	Elegans	NNP
cord-006664-ykfvbypo	379	12	development	development	NN
cord-006664-ykfvbypo	379	13	Genetic	genetic	JJ
cord-006664-ykfvbypo	379	14	control	control	NN
cord-006664-ykfvbypo	379	15	of	of	IN
cord-006664-ykfvbypo	379	16	programmed	programmed	JJ
cord-006664-ykfvbypo	379	17	cell	cell	NN
cord-006664-ykfvbypo	379	18	death	death	NN
cord-006664-ykfvbypo	379	19	in	in	IN
cord-006664-ykfvbypo	379	20	the	the	DT
cord-006664-ykfvbypo	379	21	nematode	nematode	NN
cord-006664-ykfvbypo	379	22	C.	C.	NNP
cord-006664-ykfvbypo	379	23	elegans	elegan	NNS
cord-006664-ykfvbypo	379	24	elegans	elegan	VBZ
cord-006664-ykfvbypo	379	25	survival	survival	NN
cord-006664-ykfvbypo	379	26	gene	gene	NN
cord-006664-ykfvbypo	379	27	ced-9	ced-9	NNP
cord-006664-ykfvbypo	379	28	encodes	encode	VBZ
cord-006664-ykfvbypo	379	29	a	a	DT
cord-006664-ykfvbypo	379	30	functional	functional	JJ
cord-006664-ykfvbypo	379	31	homologue	homologue	NN
cord-006664-ykfvbypo	379	32	of	of	IN
cord-006664-ykfvbypo	379	33	the	the	DT
cord-006664-ykfvbypo	379	34	mammalian	mammalian	JJ
cord-006664-ykfvbypo	379	35	protooncogene	protooncogene	NNP
cord-006664-ykfvbypo	379	36	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	379	37	Purification	Purification	NNP
cord-006664-ykfvbypo	379	38	of	of	IN
cord-006664-ykfvbypo	379	39	a	a	DT
cord-006664-ykfvbypo	379	40	24-kD	24-kd	CD
cord-006664-ykfvbypo	379	41	protease	protease	NN
cord-006664-ykfvbypo	379	42	from	from	IN
cord-006664-ykfvbypo	379	43	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	379	44	tumour	tumour	NN
cord-006664-ykfvbypo	379	45	cells	cell	NNS
cord-006664-ykfvbypo	379	46	that	that	WDT
cord-006664-ykfvbypo	379	47	activates	activate	VBZ
cord-006664-ykfvbypo	379	48	DNA	dna	NN
cord-006664-ykfvbypo	379	49	fragmentation	fragmentation	NN
cord-006664-ykfvbypo	379	50	Caspase	Caspase	NNP
cord-006664-ykfvbypo	379	51	activation	activation	NN
cord-006664-ykfvbypo	379	52	is	be	VBZ
cord-006664-ykfvbypo	379	53	required	require	VBN
cord-006664-ykfvbypo	379	54	for	for	IN
cord-006664-ykfvbypo	379	55	commitment	commitment	NN
cord-006664-ykfvbypo	379	56	to	to	IN
cord-006664-ykfvbypo	379	57	Fas	Fas	NNP
cord-006664-ykfvbypo	379	58	-	-	HYPH
cord-006664-ykfvbypo	379	59	mediated	mediate	VBN
cord-006664-ykfvbypo	379	60	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	379	61	Signal	Signal	NNP
cord-006664-ykfvbypo	379	62	transduction	transduction	NN
cord-006664-ykfvbypo	379	63	by	by	IN
cord-006664-ykfvbypo	379	64	DR3	DR3	NNP
cord-006664-ykfvbypo	379	65	,	,	,
cord-006664-ykfvbypo	379	66	a	a	DT
cord-006664-ykfvbypo	379	67	death	death	NN
cord-006664-ykfvbypo	379	68	domain	domain	NN
cord-006664-ykfvbypo	379	69	containing	contain	VBG
cord-006664-ykfvbypo	379	70	receptor	receptor	NN
cord-006664-ykfvbypo	379	71	related	relate	VBN
cord-006664-ykfvbypo	379	72	to	to	IN
cord-006664-ykfvbypo	379	73	TNFR1	TNFR1	NNP
cord-006664-ykfvbypo	379	74	and	and	CC
cord-006664-ykfvbypo	379	75	CD95	CD95	NNP
cord-006664-ykfvbypo	379	76	FADD	FADD	NNP
cord-006664-ykfvbypo	379	77	,	,	,
cord-006664-ykfvbypo	379	78	a	a	DT
cord-006664-ykfvbypo	379	79	novel	novel	JJ
cord-006664-ykfvbypo	379	80	death	death	NN
cord-006664-ykfvbypo	379	81	domain	domain	NN
cord-006664-ykfvbypo	379	82	containing	contain	VBG
cord-006664-ykfvbypo	379	83	protein	protein	NN
cord-006664-ykfvbypo	379	84	interacts	interact	VBZ
cord-006664-ykfvbypo	379	85	with	with	IN
cord-006664-ykfvbypo	379	86	the	the	DT
cord-006664-ykfvbypo	379	87	death	death	NN
cord-006664-ykfvbypo	379	88	domain	domain	NN
cord-006664-ykfvbypo	379	89	of	of	IN
cord-006664-ykfvbypo	379	90	Fas	Fas	NNP
cord-006664-ykfvbypo	379	91	and	and	CC
cord-006664-ykfvbypo	379	92	initiates	initiate	VBZ
cord-006664-ykfvbypo	379	93	apoptosis	apoptosis	VBP
cord-006664-ykfvbypo	379	94	A	a	DT
cord-006664-ykfvbypo	379	95	death	death	NN
cord-006664-ykfvbypo	379	96	domain	domain	NN
cord-006664-ykfvbypo	379	97	containing	contain	VBG
cord-006664-ykfvbypo	379	98	receptor	receptor	NN
cord-006664-ykfvbypo	379	99	that	that	WDT
cord-006664-ykfvbypo	379	100	mediates	mediate	VBZ
cord-006664-ykfvbypo	379	101	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	379	102	Sequential	sequential	JJ
cord-006664-ykfvbypo	379	103	activation	activation	NN
cord-006664-ykfvbypo	379	104	of	of	IN
cord-006664-ykfvbypo	379	105	ICE	ice	NN
cord-006664-ykfvbypo	379	106	-	-	HYPH
cord-006664-ykfvbypo	379	107	like	like	JJ
cord-006664-ykfvbypo	379	108	and	and	CC
cord-006664-ykfvbypo	379	109	CPP32-like	cpp32-like	JJ
cord-006664-ykfvbypo	379	110	proteases	protease	NNS
cord-006664-ykfvbypo	379	111	during	during	IN
cord-006664-ykfvbypo	379	112	Fas	Fas	NNP
cord-006664-ykfvbypo	379	113	-	-	HYPH
cord-006664-ykfvbypo	379	114	mediated	mediate	VBN
cord-006664-ykfvbypo	379	115	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	380	1	The	the	DT
cord-006664-ykfvbypo	380	2	BCL-2	BCL-2	NNP
cord-006664-ykfvbypo	380	3	family	family	NN
cord-006664-ykfvbypo	380	4	of	of	IN
cord-006664-ykfvbypo	380	5	proteins	protein	NNS
cord-006664-ykfvbypo	380	6	Cloning	clone	VBG
cord-006664-ykfvbypo	380	7	of	of	IN
cord-006664-ykfvbypo	380	8	the	the	DT
cord-006664-ykfvbypo	380	9	chromosome	chromosome	NN
cord-006664-ykfvbypo	380	10	breakpoint	breakpoint	NN
cord-006664-ykfvbypo	380	11	of	of	IN
cord-006664-ykfvbypo	380	12	neoplastic	neoplastic	JJ
cord-006664-ykfvbypo	380	13	B	b	NN
cord-006664-ykfvbypo	380	14	cells	cell	NNS
cord-006664-ykfvbypo	380	15	with	with	IN
cord-006664-ykfvbypo	380	16	the	the	DT
cord-006664-ykfvbypo	380	17	t(14;18	t(14;18	NNP
cord-006664-ykfvbypo	380	18	)	)	-RRB-
cord-006664-ykfvbypo	380	19	chromosome	chromosome	NN
cord-006664-ykfvbypo	380	20	translocation	translocation	NN
cord-006664-ykfvbypo	380	21	Constitutive	constitutive	JJ
cord-006664-ykfvbypo	380	22	expression	expression	NN
cord-006664-ykfvbypo	380	23	of	of	IN
cord-006664-ykfvbypo	380	24	human	human	JJ
cord-006664-ykfvbypo	380	25	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	380	26	modulates	modulate	VBZ
cord-006664-ykfvbypo	380	27	nitrogen	nitrogen	NN
cord-006664-ykfvbypo	380	28	mustard	mustard	NN
cord-006664-ykfvbypo	380	29	and	and	CC
cord-006664-ykfvbypo	380	30	campothecin	campothecin	NNS
cord-006664-ykfvbypo	380	31	induced	induce	VBN
cord-006664-ykfvbypo	381	1	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	382	1	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	382	2	oncoprotein	oncoprotein	NNP
cord-006664-ykfvbypo	382	3	blocks	blocks	NNP
cord-006664-ykfvbypo	383	1	chemotherapy	chemotherapy	NN
cord-006664-ykfvbypo	383	2	induced	induce	VBN
cord-006664-ykfvbypo	383	3	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	383	4	in	in	IN
cord-006664-ykfvbypo	383	5	a	a	DT
cord-006664-ykfvbypo	383	6	human	human	JJ
cord-006664-ykfvbypo	383	7	leukemic	leukemic	JJ
cord-006664-ykfvbypo	383	8	cell	cell	NN
cord-006664-ykfvbypo	383	9	line	line	NN
cord-006664-ykfvbypo	383	10	Programmed	program	VBD
cord-006664-ykfvbypo	383	11	cell	cell	NN
cord-006664-ykfvbypo	383	12	death	death	NN
cord-006664-ykfvbypo	383	13	and	and	CC
cord-006664-ykfvbypo	383	14	expression	expression	NN
cord-006664-ykfvbypo	383	15	of	of	IN
cord-006664-ykfvbypo	383	16	the	the	DT
cord-006664-ykfvbypo	383	17	proto	proto	JJ
cord-006664-ykfvbypo	383	18	-	-	HYPH
cord-006664-ykfvbypo	383	19	oncogene	oncogene	NN
cord-006664-ykfvbypo	383	20	bcl-2	bcl-2	NN
cord-006664-ykfvbypo	383	21	in	in	IN
cord-006664-ykfvbypo	383	22	myocytes	myocyte	NNS
cord-006664-ykfvbypo	383	23	during	during	IN
cord-006664-ykfvbypo	383	24	post	post	JJ
cord-006664-ykfvbypo	383	25	-	-	JJ
cord-006664-ykfvbypo	383	26	natal	natal	JJ
cord-006664-ykfvbypo	383	27	maturation	maturation	NN
cord-006664-ykfvbypo	383	28	of	of	IN
cord-006664-ykfvbypo	383	29	the	the	DT
cord-006664-ykfvbypo	383	30	heart	heart	NN
cord-006664-ykfvbypo	383	31	BH1	bh1	NN
cord-006664-ykfvbypo	383	32	and	and	CC
cord-006664-ykfvbypo	383	33	BH2	BH2	NNP
cord-006664-ykfvbypo	383	34	domains	domain	NNS
cord-006664-ykfvbypo	383	35	of	of	IN
cord-006664-ykfvbypo	383	36	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	383	37	are	be	VBP
cord-006664-ykfvbypo	383	38	required	require	VBN
cord-006664-ykfvbypo	383	39	for	for	IN
cord-006664-ykfvbypo	383	40	inhibition	inhibition	NN
cord-006664-ykfvbypo	383	41	of	of	IN
cord-006664-ykfvbypo	383	42	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	383	43	and	and	CC
cord-006664-ykfvbypo	383	44	heterodimerisation	heterodimerisation	NN
cord-006664-ykfvbypo	383	45	with	with	IN
cord-006664-ykfvbypo	383	46	Bax	Bax	NNP
cord-006664-ykfvbypo	383	47	Induction	Induction	NNP
cord-006664-ykfvbypo	383	48	of	of	IN
cord-006664-ykfvbypo	383	49	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	383	50	program	program	NN
cord-006664-ykfvbypo	383	51	in	in	IN
cord-006664-ykfvbypo	383	52	cell	cell	NN
cord-006664-ykfvbypo	383	53	free	free	JJ
cord-006664-ykfvbypo	383	54	extracts	extract	NNS
cord-006664-ykfvbypo	383	55	:	:	:
cord-006664-ykfvbypo	383	56	requirements	requirement	NNS
cord-006664-ykfvbypo	383	57	for	for	IN
cord-006664-ykfvbypo	383	58	dATP	datp	NN
cord-006664-ykfvbypo	383	59	and	and	CC
cord-006664-ykfvbypo	383	60	cvtochrome	cvtochrome	NNP
cord-006664-ykfvbypo	383	61	c	c	NNP
cord-006664-ykfvbypo	383	62	Molecular	Molecular	NNP
cord-006664-ykfvbypo	383	63	ordering	ordering	NN
cord-006664-ykfvbypo	383	64	of	of	IN
cord-006664-ykfvbypo	383	65	the	the	DT
cord-006664-ykfvbypo	383	66	cell	cell	NN
cord-006664-ykfvbypo	383	67	death	death	NN
cord-006664-ykfvbypo	383	68	pathway	pathway	NN
cord-006664-ykfvbypo	383	69	:	:	:
cord-006664-ykfvbypo	384	1	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	384	2	and	and	CC
cord-006664-ykfvbypo	384	3	bcl	bcl	NNP
cord-006664-ykfvbypo	384	4	-	-	HYPH
cord-006664-ykfvbypo	384	5	xl	xl	NNP
cord-006664-ykfvbypo	384	6	function	function	NN
cord-006664-ykfvbypo	384	7	upstream	upstream	RB
cord-006664-ykfvbypo	384	8	of	of	IN
cord-006664-ykfvbypo	384	9	the	the	DT
cord-006664-ykfvbypo	384	10	CED-3	CED-3	NNP
cord-006664-ykfvbypo	385	1	like	like	IN
cord-006664-ykfvbypo	385	2	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	385	3	proteases	protease	NNS
cord-006664-ykfvbypo	386	1	Fas	Fas	NNP
cord-006664-ykfvbypo	386	2	induced	induce	VBD
cord-006664-ykfvbypo	386	3	activation	activation	NN
cord-006664-ykfvbypo	386	4	of	of	IN
cord-006664-ykfvbypo	386	5	the	the	DT
cord-006664-ykfvbypo	386	6	cell	cell	NN
cord-006664-ykfvbypo	386	7	death	death	NN
cord-006664-ykfvbypo	386	8	related	relate	VBN
cord-006664-ykfvbypo	386	9	protease	protease	NN
cord-006664-ykfvbypo	386	10	CPP32	CPP32	NNP
cord-006664-ykfvbypo	386	11	is	be	VBZ
cord-006664-ykfvbypo	386	12	inhibited	inhibit	VBN
cord-006664-ykfvbypo	386	13	by	by	IN
cord-006664-ykfvbypo	386	14	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	386	15	and	and	CC
cord-006664-ykfvbypo	386	16	by	by	IN
cord-006664-ykfvbypo	386	17	ICE	ice	NN
cord-006664-ykfvbypo	386	18	family	family	NN
cord-006664-ykfvbypo	386	19	proteases	protease	NNS
cord-006664-ykfvbypo	387	1	The	the	DT
cord-006664-ykfvbypo	387	2	release	release	NN
cord-006664-ykfvbypo	387	3	of	of	IN
cord-006664-ykfvbypo	387	4	cytochrome	cytochrome	NN
cord-006664-ykfvbypo	387	5	c	c	NN
cord-006664-ykfvbypo	387	6	from	from	IN
cord-006664-ykfvbypo	387	7	mitochondria	mitochondrion	NNS
cord-006664-ykfvbypo	387	8	:	:	:
cord-006664-ykfvbypo	387	9	a	a	DT
cord-006664-ykfvbypo	387	10	primary	primary	JJ
cord-006664-ykfvbypo	387	11	site	site	NN
cord-006664-ykfvbypo	387	12	for	for	IN
cord-006664-ykfvbypo	387	13	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	387	14	regulation	regulation	NN
cord-006664-ykfvbypo	387	15	of	of	IN
cord-006664-ykfvbypo	387	16	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	387	17	Bcl-2	Bcl-2	NNP
cord-006664-ykfvbypo	387	18	functions	function	NNS
cord-006664-ykfvbypo	387	19	in	in	IN
cord-006664-ykfvbypo	387	20	an	an	DT
cord-006664-ykfvbypo	387	21	anti	anti	JJ
cord-006664-ykfvbypo	387	22	-	-	JJ
cord-006664-ykfvbypo	387	23	oxidant	oxidant	JJ
cord-006664-ykfvbypo	387	24	pathway	pathway	NN
cord-006664-ykfvbypo	387	25	to	to	TO
cord-006664-ykfvbypo	387	26	prevent	prevent	VB
cord-006664-ykfvbypo	387	27	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	387	28	Programmed	program	VBD
cord-006664-ykfvbypo	387	29	cell	cell	NN
cord-006664-ykfvbypo	387	30	death	death	NN
cord-006664-ykfvbypo	387	31	and	and	CC
cord-006664-ykfvbypo	387	32	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	387	33	protection	protection	NN
cord-006664-ykfvbypo	387	34	in	in	IN
cord-006664-ykfvbypo	387	35	very	very	RB
cord-006664-ykfvbypo	387	36	low	low	JJ
cord-006664-ykfvbypo	387	37	oxygen	oxygen	NN
cord-006664-ykfvbypo	387	38	Prevention	prevention	NN
cord-006664-ykfvbypo	387	39	of	of	IN
cord-006664-ykfvbypo	387	40	hypoxia	hypoxia	NN
cord-006664-ykfvbypo	387	41	induced	induce	VBN
cord-006664-ykfvbypo	387	42	cell	cell	NN
cord-006664-ykfvbypo	387	43	death	death	NN
cord-006664-ykfvbypo	387	44	by	by	IN
cord-006664-ykfvbypo	387	45	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	387	46	and	and	CC
cord-006664-ykfvbypo	387	47	bcl	bcl	NNP
cord-006664-ykfvbypo	387	48	-XL	-XL	HYPH
cord-006664-ykfvbypo	387	49	Bik	Bik	NNP
cord-006664-ykfvbypo	387	50	,	,	,
cord-006664-ykfvbypo	387	51	a	a	DT
cord-006664-ykfvbypo	387	52	novel	novel	JJ
cord-006664-ykfvbypo	387	53	death	death	NN
cord-006664-ykfvbypo	387	54	inducing	induce	VBG
cord-006664-ykfvbypo	387	55	protein	protein	NN
cord-006664-ykfvbypo	387	56	shares	share	NNS
cord-006664-ykfvbypo	387	57	a	a	DT
cord-006664-ykfvbypo	387	58	distinct	distinct	JJ
cord-006664-ykfvbypo	387	59	structural	structural	JJ
cord-006664-ykfvbypo	387	60	motif	motif	NN
cord-006664-ykfvbypo	387	61	with	with	IN
cord-006664-ykfvbypo	387	62	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	387	63	family	family	NN
cord-006664-ykfvbypo	387	64	proteins	protein	NNS
cord-006664-ykfvbypo	387	65	and	and	CC
cord-006664-ykfvbypo	387	66	interacts	interact	VBZ
cord-006664-ykfvbypo	387	67	with	with	IN
cord-006664-ykfvbypo	387	68	viral	viral	JJ
cord-006664-ykfvbypo	387	69	and	and	CC
cord-006664-ykfvbypo	387	70	cellular	cellular	JJ
cord-006664-ykfvbypo	387	71	survival	survival	NN
cord-006664-ykfvbypo	387	72	promoting	promote	VBG
cord-006664-ykfvbypo	387	73	proteins	protein	NNS
cord-006664-ykfvbypo	387	74	Molecular	molecular	JJ
cord-006664-ykfvbypo	387	75	thanatopsis	thanatopsis	NN
cord-006664-ykfvbypo	387	76	:	:	:
cord-006664-ykfvbypo	387	77	a	a	DT
cord-006664-ykfvbypo	387	78	discourse	discourse	NN
cord-006664-ykfvbypo	387	79	on	on	IN
cord-006664-ykfvbypo	387	80	the	the	DT
cord-006664-ykfvbypo	387	81	bcl-2	bcl-2	NNP
cord-006664-ykfvbypo	387	82	family	family	NN
cord-006664-ykfvbypo	387	83	and	and	CC
cord-006664-ykfvbypo	387	84	cell	cell	NN
cord-006664-ykfvbypo	387	85	death	death	NN
cord-006664-ykfvbypo	387	86	Regulation	regulation	NN
cord-006664-ykfvbypo	387	87	of	of	IN
cord-006664-ykfvbypo	387	88	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	387	89	by	by	IN
cord-006664-ykfvbypo	387	90	bcl-2	bcl-2	VBG
cord-006664-ykfvbypo	387	91	family	family	NN
cord-006664-ykfvbypo	387	92	proteins	protein	NNS
cord-006664-ykfvbypo	387	93	and	and	CC
cord-006664-ykfvbypo	387	94	its	-PRON-	PRP$
cord-006664-ykfvbypo	387	95	role	role	NN
cord-006664-ykfvbypo	387	96	in	in	IN
cord-006664-ykfvbypo	387	97	cancer	cancer	NN
cord-006664-ykfvbypo	387	98	and	and	CC
cord-006664-ykfvbypo	387	99	chemoresistance	chemoresistance	NN
cord-006664-ykfvbypo	387	100	Checkpoints	checkpoint	NNS
cord-006664-ykfvbypo	387	101	of	of	IN
cord-006664-ykfvbypo	387	102	dueling	duel	VBG
cord-006664-ykfvbypo	387	103	dimers	dimer	NNS
cord-006664-ykfvbypo	387	104	foil	foil	VBP
cord-006664-ykfvbypo	387	105	cell	cell	NN
cord-006664-ykfvbypo	387	106	death	death	NN
cord-006664-ykfvbypo	387	107	Evidence	evidence	NN
cord-006664-ykfvbypo	387	108	for	for	IN
cord-006664-ykfvbypo	387	109	the	the	DT
cord-006664-ykfvbypo	387	110	rapid	rapid	JJ
cord-006664-ykfvbypo	387	111	onset	onset	NN
cord-006664-ykfvbypo	387	112	of	of	IN
cord-006664-ykfvbypo	387	113	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	387	114	in	in	IN
cord-006664-ykfvbypo	387	115	medial	medial	JJ
cord-006664-ykfvbypo	387	116	smooth	smooth	JJ
cord-006664-ykfvbypo	387	117	muscle	muscle	NN
cord-006664-ykfvbypo	387	118	cells	cell	NNS
cord-006664-ykfvbypo	387	119	after	after	IN
cord-006664-ykfvbypo	387	120	balloon	balloon	NN
cord-006664-ykfvbypo	387	121	injury	injury	NN
cord-006664-ykfvbypo	388	1	Stabilised	stabilised	JJ
cord-006664-ykfvbypo	388	2	p53	p53	NN
cord-006664-ykfvbypo	388	3	facilitates	facilitate	VBZ
cord-006664-ykfvbypo	388	4	ancuploid	ancuploid	JJ
cord-006664-ykfvbypo	388	5	clonal	clonal	JJ
cord-006664-ykfvbypo	388	6	divergence	divergence	NN
cord-006664-ykfvbypo	388	7	in	in	IN
cord-006664-ykfvbypo	388	8	colorectal	colorectal	JJ
cord-006664-ykfvbypo	388	9	cancer	cancer	NN
cord-006664-ykfvbypo	388	10	p53	p53	NN
cord-006664-ykfvbypo	388	11	and	and	CC
cord-006664-ykfvbypo	388	12	the	the	DT
cord-006664-ykfvbypo	388	13	hypoxia	hypoxia	NN
cord-006664-ykfvbypo	388	14	induced	induce	VBN
cord-006664-ykfvbypo	388	15	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	388	16	of	of	IN
cord-006664-ykfvbypo	388	17	cultured	cultured	JJ
cord-006664-ykfvbypo	388	18	neonatal	neonatal	JJ
cord-006664-ykfvbypo	388	19	rat	rat	NN
cord-006664-ykfvbypo	388	20	cardiac	cardiac	NN
cord-006664-ykfvbypo	388	21	myocytes	myocyte	NNS
cord-006664-ykfvbypo	389	1	Adenovirus	Adenovirus	NNP
cord-006664-ykfvbypo	389	2	E1A	e1a	NN
cord-006664-ykfvbypo	389	3	represses	repress	VBZ
cord-006664-ykfvbypo	389	4	cardiac	cardiac	JJ
cord-006664-ykfvbypo	389	5	gene	gene	NN
cord-006664-ykfvbypo	389	6	transcription	transcription	NN
cord-006664-ykfvbypo	389	7	and	and	CC
cord-006664-ykfvbypo	389	8	reactivates	reactivate	VBZ
cord-006664-ykfvbypo	389	9	DNA	dna	NN
cord-006664-ykfvbypo	389	10	synthesis	synthesis	NN
cord-006664-ykfvbypo	389	11	in	in	IN
cord-006664-ykfvbypo	389	12	ventricular	ventricular	JJ
cord-006664-ykfvbypo	389	13	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	389	14	,	,	,
cord-006664-ykfvbypo	389	15	via	via	IN
cord-006664-ykfvbypo	389	16	alternate	alternate	JJ
cord-006664-ykfvbypo	389	17	pocket	pocket	NN
cord-006664-ykfvbypo	389	18	protein	protein	NN
cord-006664-ykfvbypo	389	19	and	and	CC
cord-006664-ykfvbypo	389	20	p300	p300	NNP
cord-006664-ykfvbypo	389	21	binding	bind	VBG
cord-006664-ykfvbypo	389	22	domains	domain	NNS
cord-006664-ykfvbypo	389	23	Adenoviral	Adenoviral	NNP
cord-006664-ykfvbypo	389	24	delivery	delivery	NN
cord-006664-ykfvbypo	389	25	of	of	IN
cord-006664-ykfvbypo	389	26	E2F-1	E2F-1	NNP
cord-006664-ykfvbypo	389	27	directs	direct	VBZ
cord-006664-ykfvbypo	389	28	cell	cell	NN
cord-006664-ykfvbypo	389	29	cycle	cycle	NN
cord-006664-ykfvbypo	389	30	re	re	NN
cord-006664-ykfvbypo	389	31	-	-	NN
cord-006664-ykfvbypo	389	32	entry	entry	NN
cord-006664-ykfvbypo	390	1	and	and	CC
cord-006664-ykfvbypo	390	2	p53	p53	NN
cord-006664-ykfvbypo	390	3	independent	independent	JJ
cord-006664-ykfvbypo	390	4	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	390	5	in	in	IN
cord-006664-ykfvbypo	390	6	post	post	JJ
cord-006664-ykfvbypo	390	7	-	-	JJ
cord-006664-ykfvbypo	390	8	mitotic	mitotic	JJ
cord-006664-ykfvbypo	390	9	adult	adult	NN
cord-006664-ykfvbypo	390	10	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	391	1	in	in	IN
cord-006664-ykfvbypo	391	2	vitro	vitro	FW
cord-006664-ykfvbypo	392	1	Myocyte	Myocyte	NNP
cord-006664-ykfvbypo	392	2	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	392	3	during	during	IN
cord-006664-ykfvbypo	392	4	acute	acute	JJ
cord-006664-ykfvbypo	392	5	myocardial	myocardial	JJ
cord-006664-ykfvbypo	392	6	infarction	infarction	NN
cord-006664-ykfvbypo	392	7	in	in	IN
cord-006664-ykfvbypo	392	8	the	the	DT
cord-006664-ykfvbypo	392	9	mouse	mouse	NN
cord-006664-ykfvbypo	392	10	localizes	localize	VBZ
cord-006664-ykfvbypo	392	11	to	to	IN
cord-006664-ykfvbypo	392	12	hypoxic	hypoxic	JJ
cord-006664-ykfvbypo	392	13	regions	region	NNS
cord-006664-ykfvbypo	392	14	but	but	CC
cord-006664-ykfvbypo	392	15	occurs	occur	VBZ
cord-006664-ykfvbypo	392	16	independently	independently	RB
cord-006664-ykfvbypo	392	17	of	of	IN
cord-006664-ykfvbypo	392	18	p53	p53	NN
cord-006664-ykfvbypo	393	1	The	the	DT
cord-006664-ykfvbypo	393	2	bcl-2	bcl-2	NN
cord-006664-ykfvbypo	393	3	gene	gene	NN
cord-006664-ykfvbypo	393	4	product	product	NN
cord-006664-ykfvbypo	393	5	prevents	prevent	VBZ
cord-006664-ykfvbypo	393	6	programmed	program	VBN
cord-006664-ykfvbypo	393	7	cell	cell	NN
cord-006664-ykfvbypo	393	8	death	death	NN
cord-006664-ykfvbypo	393	9	of	of	IN
cord-006664-ykfvbypo	393	10	ventricular	ventricular	JJ
cord-006664-ykfvbypo	393	11	myocytes	myocyte	NNS
cord-006664-ykfvbypo	393	12	Regulators	regulator	NNS
cord-006664-ykfvbypo	393	13	of	of	IN
cord-006664-ykfvbypo	393	14	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	393	15	in	in	IN
cord-006664-ykfvbypo	393	16	the	the	DT
cord-006664-ykfvbypo	393	17	heart	heart	NN
cord-006664-ykfvbypo	393	18	:	:	:
cord-006664-ykfvbypo	393	19	a	a	DT
cord-006664-ykfvbypo	393	20	matter	matter	NN
cord-006664-ykfvbypo	393	21	of	of	IN
cord-006664-ykfvbypo	393	22	life	life	NN
cord-006664-ykfvbypo	393	23	or	or	CC
cord-006664-ykfvbypo	393	24	death	death	NN
cord-006664-ykfvbypo	394	1	The	the	DT
cord-006664-ykfvbypo	394	2	discovery	discovery	NN
cord-006664-ykfvbypo	394	3	of	of	IN
cord-006664-ykfvbypo	394	4	endothelium	endothelium	NN
cord-006664-ykfvbypo	394	5	-	-	HYPH
cord-006664-ykfvbypo	394	6	derived	derive	VBN
cord-006664-ykfvbypo	394	7	relaxing	relaxing	JJ
cord-006664-ykfvbypo	394	8	factor	factor	NN
cord-006664-ykfvbypo	394	9	and	and	CC
cord-006664-ykfvbypo	394	10	its	-PRON-	PRP$
cord-006664-ykfvbypo	394	11	importance	importance	NN
cord-006664-ykfvbypo	394	12	in	in	IN
cord-006664-ykfvbypo	394	13	the	the	DT
cord-006664-ykfvbypo	394	14	identification	identification	NN
cord-006664-ykfvbypo	394	15	of	of	IN
cord-006664-ykfvbypo	394	16	nitric	nitric	NN
cord-006664-ykfvbypo	394	17	oxide	oxide	NN
cord-006664-ykfvbypo	395	1	The	the	DT
cord-006664-ykfvbypo	395	2	role	role	NN
cord-006664-ykfvbypo	395	3	of	of	IN
cord-006664-ykfvbypo	395	4	chemical	chemical	JJ
cord-006664-ykfvbypo	395	5	mediators	mediator	NNS
cord-006664-ykfvbypo	395	6	released	release	VBN
cord-006664-ykfvbypo	395	7	by	by	IN
cord-006664-ykfvbypo	395	8	the	the	DT
cord-006664-ykfvbypo	395	9	endothelium	endothelium	NN
cord-006664-ykfvbypo	395	10	in	in	IN
cord-006664-ykfvbypo	395	11	the	the	DT
cord-006664-ykfvbypo	395	12	control	control	NN
cord-006664-ykfvbypo	395	13	of	of	IN
cord-006664-ykfvbypo	395	14	the	the	DT
cord-006664-ykfvbypo	395	15	cardiovascular	cardiovascular	JJ
cord-006664-ykfvbypo	395	16	system	system	NN
cord-006664-ykfvbypo	395	17	Nitric	nitric	NN
cord-006664-ykfvbypo	395	18	oxide	oxide	NN
cord-006664-ykfvbypo	395	19	synthases	synthase	NNS
cord-006664-ykfvbypo	395	20	and	and	CC
cord-006664-ykfvbypo	395	21	cardiac	cardiac	JJ
cord-006664-ykfvbypo	395	22	muscle	muscle	NN
cord-006664-ykfvbypo	395	23	:	:	:
cord-006664-ykfvbypo	395	24	autocrine	autocrine	NN
cord-006664-ykfvbypo	395	25	and	and	CC
cord-006664-ykfvbypo	395	26	paracrine	paracrine	JJ
cord-006664-ykfvbypo	395	27	influences	influence	NNS
cord-006664-ykfvbypo	396	1	Induction	induction	NN
cord-006664-ykfvbypo	396	2	of	of	IN
cord-006664-ykfvbypo	396	3	myocardial	myocardial	JJ
cord-006664-ykfvbypo	396	4	nitric	nitric	NN
cord-006664-ykfvbypo	396	5	oxide	oxide	NN
cord-006664-ykfvbypo	396	6	synthase	synthase	NN
cord-006664-ykfvbypo	396	7	by	by	IN
cord-006664-ykfvbypo	396	8	cardiac	cardiac	JJ
cord-006664-ykfvbypo	396	9	allograft	allograft	NN
cord-006664-ykfvbypo	396	10	rejection	rejection	NN
cord-006664-ykfvbypo	396	11	Cellular	Cellular	NNP
cord-006664-ykfvbypo	396	12	and	and	CC
cord-006664-ykfvbypo	396	13	molecular	molecular	JJ
cord-006664-ykfvbypo	396	14	cardiovascular	cardiovascular	JJ
cord-006664-ykfvbypo	396	15	disease	disease	NN
cord-006664-ykfvbypo	396	16	:	:	:
cord-006664-ykfvbypo	396	17	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	396	18	of	of	IN
cord-006664-ykfvbypo	396	19	cardiac	cardiac	JJ
cord-006664-ykfvbypo	396	20	myocytes	myocyte	NNS
cord-006664-ykfvbypo	396	21	during	during	IN
cord-006664-ykfvbypo	396	22	cardiac	cardiac	JJ
cord-006664-ykfvbypo	396	23	allograft	allograft	NN
cord-006664-ykfvbypo	396	24	rejection	rejection	NN
cord-006664-ykfvbypo	396	25	:	:	:
cord-006664-ykfvbypo	396	26	relation	relation	NN
cord-006664-ykfvbypo	396	27	to	to	IN
cord-006664-ykfvbypo	396	28	induction	induction	NN
cord-006664-ykfvbypo	396	29	of	of	IN
cord-006664-ykfvbypo	396	30	nitric	nitric	JJ
cord-006664-ykfvbypo	396	31	oxide	oxide	NN
cord-006664-ykfvbypo	396	32	synthase	synthase	NN
cord-006664-ykfvbypo	396	33	Number	number	NN
cord-006664-ykfvbypo	396	34	2	2	CD
cord-006664-ykfvbypo	396	35	induced	induce	VBD
cord-006664-ykfvbypo	396	36	nitric	nitric	JJ
cord-006664-ykfvbypo	396	37	oxide	oxide	NN
cord-006664-ykfvbypo	396	38	in	in	IN
cord-006664-ykfvbypo	396	39	cardiac	cardiac	JJ
cord-006664-ykfvbypo	396	40	myocytes	myocyte	NNS
cord-006664-ykfvbypo	396	41	are	be	VBP
cord-006664-ykfvbypo	396	42	blocked	block	VBN
cord-006664-ykfvbypo	396	43	by	by	IN
cord-006664-ykfvbypo	396	44	nitric	nitric	NN
cord-006664-ykfvbypo	396	45	oxide	oxide	NN
cord-006664-ykfvbypo	396	46	synthase	synthase	NN
cord-006664-ykfvbypo	396	47	antagonism	antagonism	NN
cord-006664-ykfvbypo	396	48	or	or	CC
cord-006664-ykfvbypo	396	49	transforming	transform	VBG
cord-006664-ykfvbypo	396	50	growth	growth	NN
cord-006664-ykfvbypo	396	51	factor	factor	NN
cord-006664-ykfvbypo	396	52	beta	beta	NN
cord-006664-ykfvbypo	397	1	In	in	IN
cord-006664-ykfvbypo	397	2	vivo	vivo	NN
cord-006664-ykfvbypo	397	3	gene	gene	NN
cord-006664-ykfvbypo	397	4	transfection	transfection	NN
cord-006664-ykfvbypo	397	5	of	of	IN
cord-006664-ykfvbypo	397	6	human	human	JJ
cord-006664-ykfvbypo	397	7	endothelial	endothelial	JJ
cord-006664-ykfvbypo	397	8	cell	cell	NN
cord-006664-ykfvbypo	397	9	nitric	nitric	NN
cord-006664-ykfvbypo	397	10	oxide	oxide	NN
cord-006664-ykfvbypo	397	11	synthase	synthase	NN
cord-006664-ykfvbypo	397	12	in	in	IN
cord-006664-ykfvbypo	397	13	cardiomyocytes	cardiomyocyte	NNS
cord-006664-ykfvbypo	397	14	causes	cause	VBZ
cord-006664-ykfvbypo	397	15	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	397	16	like	like	IN
cord-006664-ykfvbypo	397	17	cell	cell	NN
cord-006664-ykfvbypo	397	18	death	death	NN
cord-006664-ykfvbypo	397	19	;	;	:
cord-006664-ykfvbypo	397	20	Identification	identification	NN
cord-006664-ykfvbypo	397	21	using	use	VBG
cord-006664-ykfvbypo	397	22	Sendai	Sendai	NNP
cord-006664-ykfvbypo	397	23	virus	virus	NN
cord-006664-ykfvbypo	397	24	coated	coat	VBN
cord-006664-ykfvbypo	397	25	particles	particle	NNS
cord-006664-ykfvbypo	397	26	Nitric	nitric	NN
cord-006664-ykfvbypo	397	27	oxide	oxide	NN
cord-006664-ykfvbypo	397	28	attenuates	attenuate	VBZ
cord-006664-ykfvbypo	397	29	vascular	vascular	JJ
cord-006664-ykfvbypo	397	30	smooth	smooth	JJ
cord-006664-ykfvbypo	397	31	muscle	muscle	NN
cord-006664-ykfvbypo	397	32	activation	activation	NN
cord-006664-ykfvbypo	397	33	by	by	IN
cord-006664-ykfvbypo	397	34	interferon	interferon	NN
cord-006664-ykfvbypo	397	35	gamma	gamma	NN
cord-006664-ykfvbypo	397	36	Mechanisms	Mechanisms	NNPS
cord-006664-ykfvbypo	397	37	and	and	CC
cord-006664-ykfvbypo	397	38	genes	gene	NNS
cord-006664-ykfvbypo	397	39	of	of	IN
cord-006664-ykfvbypo	397	40	cellular	cellular	JJ
cord-006664-ykfvbypo	397	41	suicide	suicide	NN
cord-006664-ykfvbypo	398	1	Vascular	vascular	JJ
cord-006664-ykfvbypo	398	2	smooth	smooth	JJ
cord-006664-ykfvbypo	398	3	muscle	muscle	NN
cord-006664-ykfvbypo	398	4	cells	cell	NNS
cord-006664-ykfvbypo	398	5	express	express	VBP
cord-006664-ykfvbypo	398	6	a	a	DT
cord-006664-ykfvbypo	398	7	constitutive	constitutive	JJ
cord-006664-ykfvbypo	398	8	NF	nf	NN
cord-006664-ykfvbypo	398	9	-	-	HYPH
cord-006664-ykfvbypo	398	10	kB	kB	NNP
cord-006664-ykfvbypo	399	1	like	like	IN
cord-006664-ykfvbypo	399	2	activity	activity	NN
cord-006664-ykfvbypo	399	3	NF	nf	NN
cord-006664-ykfvbypo	399	4	-	-	HYPH
cord-006664-ykfvbypo	399	5	kB	kB	NNP
cord-006664-ykfvbypo	399	6	is	be	VBZ
cord-006664-ykfvbypo	399	7	induced	induce	VBN
cord-006664-ykfvbypo	399	8	in	in	IN
cord-006664-ykfvbypo	399	9	the	the	DT
cord-006664-ykfvbypo	399	10	nuclei	nucleus	NNS
cord-006664-ykfvbypo	399	11	of	of	IN
cord-006664-ykfvbypo	399	12	cultured	cultured	JJ
cord-006664-ykfvbypo	399	13	rat	rat	NN
cord-006664-ykfvbypo	399	14	aortic	aortic	JJ
cord-006664-ykfvbypo	399	15	smooth	smooth	JJ
cord-006664-ykfvbypo	399	16	muscle	muscle	NN
cord-006664-ykfvbypo	399	17	cells	cell	NNS
cord-006664-ykfvbypo	399	18	by	by	IN
cord-006664-ykfvbypo	399	19	stimulation	stimulation	NN
cord-006664-ykfvbypo	399	20	of	of	IN
cord-006664-ykfvbypo	399	21	various	various	JJ
cord-006664-ykfvbypo	399	22	growth	growth	NN
cord-006664-ykfvbypo	399	23	factors	factor	NNS
cord-006664-ykfvbypo	399	24	Expression	expression	NN
cord-006664-ykfvbypo	399	25	of	of	IN
cord-006664-ykfvbypo	399	26	an	an	DT
cord-006664-ykfvbypo	399	27	NF	NF	NNP
cord-006664-ykfvbypo	399	28	-	-	HYPH
cord-006664-ykfvbypo	399	29	kB	kB	NNP
cord-006664-ykfvbypo	399	30	like	like	IN
cord-006664-ykfvbypo	399	31	activity	activity	NN
cord-006664-ykfvbypo	400	1	is	be	VBZ
cord-006664-ykfvbypo	400	2	essential	essential	JJ
cord-006664-ykfvbypo	400	3	for	for	IN
cord-006664-ykfvbypo	400	4	proliferation	proliferation	NN
cord-006664-ykfvbypo	400	5	of	of	IN
cord-006664-ykfvbypo	400	6	cultured	cultured	JJ
cord-006664-ykfvbypo	400	7	bovine	bovine	JJ
cord-006664-ykfvbypo	400	8	vascular	vascular	JJ
cord-006664-ykfvbypo	400	9	smooth	smooth	JJ
cord-006664-ykfvbypo	400	10	muscle	muscle	NN
cord-006664-ykfvbypo	400	11	cells	cell	NNS
cord-006664-ykfvbypo	400	12	Activated	activate	VBN
cord-006664-ykfvbypo	400	13	transcription	transcription	NN
cord-006664-ykfvbypo	400	14	factor	factor	NN
cord-006664-ykfvbypo	400	15	nuclear	nuclear	JJ
cord-006664-ykfvbypo	400	16	factor	factor	NN
cord-006664-ykfvbypo	400	17	-	-	HYPH
cord-006664-ykfvbypo	400	18	kB	kB	NNP
cord-006664-ykfvbypo	400	19	is	be	VBZ
cord-006664-ykfvbypo	400	20	present	present	JJ
cord-006664-ykfvbypo	400	21	in	in	IN
cord-006664-ykfvbypo	400	22	the	the	DT
cord-006664-ykfvbypo	400	23	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	400	24	lesion	lesion	NN
cord-006664-ykfvbypo	400	25	Expression	expression	NN
cord-006664-ykfvbypo	400	26	of	of	IN
cord-006664-ykfvbypo	400	27	NF	NF	NNP
cord-006664-ykfvbypo	400	28	-	-	HYPH
cord-006664-ykfvbypo	400	29	kB	kB	NNP
cord-006664-ykfvbypo	400	30	and	and	CC
cord-006664-ykfvbypo	400	31	Ik	Ik	NNP
cord-006664-ykfvbypo	400	32	-	-	HYPH
cord-006664-ykfvbypo	400	33	B	B	NNP
cord-006664-ykfvbypo	400	34	by	by	IN
cord-006664-ykfvbypo	400	35	aortic	aortic	JJ
cord-006664-ykfvbypo	400	36	endothelium	endothelium	NN
cord-006664-ykfvbypo	400	37	in	in	IN
cord-006664-ykfvbypo	400	38	an	an	DT
cord-006664-ykfvbypo	400	39	arterial	arterial	JJ
cord-006664-ykfvbypo	400	40	injury	injury	NN
cord-006664-ykfvbypo	400	41	model	model	NN
cord-006664-ykfvbypo	400	42	Tumour	tumour	NN
cord-006664-ykfvbypo	400	43	necrosis	necrosis	NN
cord-006664-ykfvbypo	400	44	factor	factor	NN
cord-006664-ykfvbypo	400	45	can	can	MD
cord-006664-ykfvbypo	400	46	induce	induce	VB
cord-006664-ykfvbypo	400	47	both	both	DT
cord-006664-ykfvbypo	400	48	apoptotic	apoptotic	JJ
cord-006664-ykfvbypo	400	49	and	and	CC
cord-006664-ykfvbypo	400	50	necrotic	necrotic	JJ
cord-006664-ykfvbypo	400	51	forms	form	NNS
cord-006664-ykfvbypo	400	52	of	of	IN
cord-006664-ykfvbypo	400	53	cell	cell	NN
cord-006664-ykfvbypo	400	54	lysis	lysis	NN
cord-006664-ykfvbypo	400	55	Evidence	evidence	NN
cord-006664-ykfvbypo	400	56	of	of	IN
cord-006664-ykfvbypo	400	57	cardiocyte	cardiocyte	NN
cord-006664-ykfvbypo	400	58	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	400	59	in	in	IN
cord-006664-ykfvbypo	400	60	myocardium	myocardium	NN
cord-006664-ykfvbypo	400	61	of	of	IN
cord-006664-ykfvbypo	400	62	dogs	dog	NNS
cord-006664-ykfvbypo	400	63	with	with	IN
cord-006664-ykfvbypo	400	64	chronic	chronic	JJ
cord-006664-ykfvbypo	400	65	heart	heart	NN
cord-006664-ykfvbypo	400	66	failure	failure	NN
cord-006664-ykfvbypo	401	1	Tumour	tumour	NN
cord-006664-ykfvbypo	401	2	necrosis	necrosis	NN
cord-006664-ykfvbypo	401	3	factor-	factor-	XX
cord-006664-ykfvbypo	402	1	(	(	-LRB-
cord-006664-ykfvbypo	402	2	and	and	CC
cord-006664-ykfvbypo	402	3	tumour	tumour	NN
cord-006664-ykfvbypo	402	4	necrosis	necrosis	NN
cord-006664-ykfvbypo	402	5	factor	factor	NN
cord-006664-ykfvbypo	402	6	receptor	receptor	NN
cord-006664-ykfvbypo	402	7	in	in	IN
cord-006664-ykfvbypo	402	8	the	the	DT
cord-006664-ykfvbypo	402	9	failing	fail	VBG
cord-006664-ykfvbypo	402	10	human	human	JJ
cord-006664-ykfvbypo	402	11	heart	heart	NN
cord-006664-ykfvbypo	402	12	Apoptosis	Apoptosis	NNP
cord-006664-ykfvbypo	402	13	in	in	IN
cord-006664-ykfvbypo	402	14	congestive	congestive	JJ
cord-006664-ykfvbypo	402	15	heart	heart	NN
cord-006664-ykfvbypo	402	16	failure	failure	NN
cord-006664-ykfvbypo	402	17	induced	induce	VBN
cord-006664-ykfvbypo	402	18	by	by	IN
cord-006664-ykfvbypo	402	19	viral	viral	JJ
cord-006664-ykfvbypo	402	20	myocarditis	myocarditis	NN
cord-006664-ykfvbypo	402	21	in	in	IN
cord-006664-ykfvbypo	402	22	mice	mouse	NNS
cord-006664-ykfvbypo	402	23	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	402	24	and	and	CC
cord-006664-ykfvbypo	402	25	DNA	dna	NN
cord-006664-ykfvbypo	402	26	fragmentation	fragmentation	NN
cord-006664-ykfvbypo	402	27	in	in	IN
cord-006664-ykfvbypo	402	28	the	the	DT
cord-006664-ykfvbypo	402	29	bulbis	bulbis	NNP
cord-006664-ykfvbypo	402	30	cordis	cordis	NN
cord-006664-ykfvbypo	402	31	of	of	IN
cord-006664-ykfvbypo	402	32	the	the	DT
cord-006664-ykfvbypo	402	33	developing	develop	VBG
cord-006664-ykfvbypo	402	34	rat	rat	NN
cord-006664-ykfvbypo	402	35	heart	heart	NN
cord-006664-ykfvbypo	402	36	Normal	normal	JJ
cord-006664-ykfvbypo	402	37	and	and	CC
cord-006664-ykfvbypo	402	38	abnormal	abnormal	JJ
cord-006664-ykfvbypo	402	39	consequences	consequence	NNS
cord-006664-ykfvbypo	402	40	of	of	IN
cord-006664-ykfvbypo	402	41	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	402	42	in	in	IN
cord-006664-ykfvbypo	402	43	the	the	DT
cord-006664-ykfvbypo	402	44	human	human	JJ
cord-006664-ykfvbypo	402	45	heart	heart	NN
cord-006664-ykfvbypo	402	46	:	:	:
cord-006664-ykfvbypo	402	47	from	from	IN
cord-006664-ykfvbypo	402	48	post	post	JJ
cord-006664-ykfvbypo	402	49	-	-	JJ
cord-006664-ykfvbypo	402	50	natal	natal	JJ
cord-006664-ykfvbypo	402	51	morphogenesis	morphogenesis	NN
cord-006664-ykfvbypo	402	52	to	to	IN
cord-006664-ykfvbypo	402	53	paroxysmal	paroxysmal	JJ
cord-006664-ykfvbypo	402	54	arrhvthmias	arrhvthmia	NNS
cord-006664-ykfvbypo	402	55	Apoptosis	Apoptosis	NNP
cord-006664-ykfvbypo	402	56	in	in	IN
cord-006664-ykfvbypo	402	57	arteries	artery	NNS
cord-006664-ykfvbypo	402	58	of	of	IN
cord-006664-ykfvbypo	402	59	the	the	DT
cord-006664-ykfvbypo	402	60	neonatal	neonatal	JJ
cord-006664-ykfvbypo	402	61	lamb	lamb	NN
cord-006664-ykfvbypo	403	1	The	the	DT
cord-006664-ykfvbypo	403	2	tunica	tunica	NNP
cord-006664-ykfvbypo	403	3	media	medium	NNS
cord-006664-ykfvbypo	403	4	in	in	IN
cord-006664-ykfvbypo	403	5	aging	age	VBG
cord-006664-ykfvbypo	403	6	rats	rat	NNS
cord-006664-ykfvbypo	403	7	Evidence	evidence	NN
cord-006664-ykfvbypo	403	8	for	for	IN
cord-006664-ykfvbypo	403	9	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	403	10	in	in	IN
cord-006664-ykfvbypo	403	11	human	human	JJ
cord-006664-ykfvbypo	403	12	atherogenesis	atherogenesis	NN
cord-006664-ykfvbypo	403	13	and	and	CC
cord-006664-ykfvbypo	403	14	in	in	IN
cord-006664-ykfvbypo	403	15	a	a	DT
cord-006664-ykfvbypo	403	16	rat	rat	NN
cord-006664-ykfvbypo	403	17	vascular	vascular	JJ
cord-006664-ykfvbypo	403	18	injury	injury	NN
cord-006664-ykfvbypo	403	19	model	model	NN
cord-006664-ykfvbypo	403	20	Contributions	Contributions	NNPS
cord-006664-ykfvbypo	403	21	of	of	IN
cord-006664-ykfvbypo	403	22	ischaemia	ischaemia	NN
cord-006664-ykfvbypo	403	23	and	and	CC
cord-006664-ykfvbypo	403	24	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	403	25	to	to	IN
cord-006664-ykfvbypo	403	26	mucosal	mucosal	JJ
cord-006664-ykfvbypo	403	27	lesion	lesion	NN
cord-006664-ykfvbypo	403	28	formation	formation	NN
cord-006664-ykfvbypo	403	29	Introduction	introduction	NN
cord-006664-ykfvbypo	403	30	.	.	.
cord-006664-ykfvbypo	404	1	Oxidative	oxidative	JJ
cord-006664-ykfvbypo	404	2	stress	stress	NN
cord-006664-ykfvbypo	405	1	Does	do	VBZ
cord-006664-ykfvbypo	405	2	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	405	3	injury	injury	NN
cord-006664-ykfvbypo	405	4	exist	exist	VBP
cord-006664-ykfvbypo	405	5	in	in	IN
cord-006664-ykfvbypo	405	6	humans	human	NNS
cord-006664-ykfvbypo	405	7	Stretch	stretch	VBP
cord-006664-ykfvbypo	406	1	induced	induce	VBN
cord-006664-ykfvbypo	406	2	programmed	program	VBD
cord-006664-ykfvbypo	406	3	myocyte	myocyte	NNP
cord-006664-ykfvbypo	406	4	cell	cell	NN
cord-006664-ykfvbypo	406	5	death	death	NN
cord-006664-ykfvbypo	406	6	Forging	forge	VBG
cord-006664-ykfvbypo	406	7	a	a	DT
cord-006664-ykfvbypo	406	8	path	path	NN
cord-006664-ykfvbypo	406	9	to	to	IN
cord-006664-ykfvbypo	406	10	cell	cell	NN
cord-006664-ykfvbypo	406	11	death	death	NN
cord-006664-ykfvbypo	406	12	Basic	basic	JJ
cord-006664-ykfvbypo	406	13	mechanisms	mechanism	NNS
cord-006664-ykfvbypo	406	14	in	in	IN
cord-006664-ykfvbypo	406	15	heart	heart	NN
cord-006664-ykfvbypo	406	16	failure	failure	NN
cord-006664-ykfvbypo	406	17	:	:	:
cord-006664-ykfvbypo	406	18	the	the	DT
cord-006664-ykfvbypo	406	19	cytokine	cytokine	NN
cord-006664-ykfvbypo	406	20	hypothesis	hypothesis	NN
cord-006664-ykfvbypo	407	1	Overexpression	overexpression	NN
cord-006664-ykfvbypo	407	2	of	of	IN
cord-006664-ykfvbypo	407	3	manganese	manganese	NN
cord-006664-ykfvbypo	407	4	superoxide	superoxide	NN
cord-006664-ykfvbypo	407	5	dismutase	dismutase	NN
cord-006664-ykfvbypo	407	6	promotes	promote	VBZ
cord-006664-ykfvbypo	407	7	the	the	DT
cord-006664-ykfvbypo	407	8	survival	survival	NN
cord-006664-ykfvbypo	407	9	of	of	IN
cord-006664-ykfvbypo	407	10	tumour	tumour	NN
cord-006664-ykfvbypo	407	11	cells	cell	NNS
cord-006664-ykfvbypo	407	12	exposed	expose	VBN
cord-006664-ykfvbypo	407	13	to	to	IN
cord-006664-ykfvbypo	407	14	interleukin	interleukin	NN
cord-006664-ykfvbypo	407	15	1	1	CD
cord-006664-ykfvbypo	407	16	,	,	,
cord-006664-ykfvbypo	407	17	tumour	tumour	NN
cord-006664-ykfvbypo	407	18	necrosis	necrosis	NN
cord-006664-ykfvbypo	407	19	factor	factor	NN
cord-006664-ykfvbypo	407	20	selected	select	VBN
cord-006664-ykfvbypo	407	21	anti	anti	JJ
cord-006664-ykfvbypo	407	22	-	-	JJ
cord-006664-ykfvbypo	407	23	cancer	cancer	JJ
cord-006664-ykfvbypo	407	24	drugs	drug	NNS
cord-006664-ykfvbypo	407	25	and	and	CC
cord-006664-ykfvbypo	407	26	ionising	ionise	VBG
cord-006664-ykfvbypo	407	27	radiation	radiation	NN
cord-006664-ykfvbypo	407	28	Oxidative	oxidative	JJ
cord-006664-ykfvbypo	407	29	stress	stress	NN
cord-006664-ykfvbypo	408	1	induced	induce	VBN
cord-006664-ykfvbypo	408	2	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	408	3	prevented	prevent	VBN
cord-006664-ykfvbypo	408	4	by	by	IN
cord-006664-ykfvbypo	408	5	Trolox	Trolox	NNP
cord-006664-ykfvbypo	408	6	Cellular	Cellular	NNP
cord-006664-ykfvbypo	408	7	mechanisms	mechanism	NNS
cord-006664-ykfvbypo	408	8	of	of	IN
cord-006664-ykfvbypo	408	9	endothelial	endothelial	JJ
cord-006664-ykfvbypo	408	10	cell	cell	NN
cord-006664-ykfvbypo	408	11	death	death	NN
cord-006664-ykfvbypo	408	12	during	during	IN
cord-006664-ykfvbypo	409	1	the	the	DT
cord-006664-ykfvbypo	409	2	systemic	systemic	JJ
cord-006664-ykfvbypo	409	3	inflammatory	inflammatory	JJ
cord-006664-ykfvbypo	409	4	response	response	NN
cord-006664-ykfvbypo	409	5	syndrome	syndrome	NN
cord-006664-ykfvbypo	409	6	Apoptosis	Apoptosis	NNP
cord-006664-ykfvbypo	409	7	in	in	IN
cord-006664-ykfvbypo	409	8	pressure	pressure	NN
cord-006664-ykfvbypo	409	9	overload	overload	NN
cord-006664-ykfvbypo	409	10	induced	induce	VBD
cord-006664-ykfvbypo	409	11	heart	heart	NN
cord-006664-ykfvbypo	409	12	hypertrophy	hypertrophy	NN
cord-006664-ykfvbypo	409	13	in	in	IN
cord-006664-ykfvbypo	409	14	the	the	DT
cord-006664-ykfvbypo	409	15	rat	rat	NN
cord-006664-ykfvbypo	409	16	Apoptosis	Apoptosis	NNP
cord-006664-ykfvbypo	409	17	in	in	IN
cord-006664-ykfvbypo	409	18	target	target	NN
cord-006664-ykfvbypo	409	19	organs	organ	NNS
cord-006664-ykfvbypo	409	20	of	of	IN
cord-006664-ykfvbypo	409	21	hypertension	hypertension	NN
cord-006664-ykfvbypo	409	22	Stretch	stretch	NN
cord-006664-ykfvbypo	409	23	mediated	mediate	VBN
cord-006664-ykfvbypo	409	24	release	release	NN
cord-006664-ykfvbypo	409	25	of	of	IN
cord-006664-ykfvbypo	409	26	angiotensin	angiotensin	NN
cord-006664-ykfvbypo	409	27	II	II	NNP
cord-006664-ykfvbypo	409	28	induces	induce	VBZ
cord-006664-ykfvbypo	409	29	myocyte	myocyte	NNP
cord-006664-ykfvbypo	409	30	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	409	31	by	by	IN
cord-006664-ykfvbypo	409	32	activating	activate	VBG
cord-006664-ykfvbypo	409	33	p53	p53	NN
cord-006664-ykfvbypo	409	34	that	that	WDT
cord-006664-ykfvbypo	409	35	enhances	enhance	VBZ
cord-006664-ykfvbypo	409	36	the	the	DT
cord-006664-ykfvbypo	409	37	local	local	JJ
cord-006664-ykfvbypo	409	38	renin	renin	NN
cord-006664-ykfvbypo	409	39	angiotensin	angiotensin	NN
cord-006664-ykfvbypo	409	40	system	system	NN
cord-006664-ykfvbypo	409	41	and	and	CC
cord-006664-ykfvbypo	409	42	decreases	decrease	VBZ
cord-006664-ykfvbypo	409	43	the	the	DT
cord-006664-ykfvbypo	409	44	bcl-2	bcl-2	NN
cord-006664-ykfvbypo	409	45	to	to	IN
cord-006664-ykfvbypo	409	46	bax	bax	NNP
cord-006664-ykfvbypo	409	47	protein	protein	NNP
cord-006664-ykfvbypo	409	48	ratio	ratio	NN
cord-006664-ykfvbypo	409	49	in	in	IN
cord-006664-ykfvbypo	409	50	the	the	DT
cord-006664-ykfvbypo	409	51	cell	cell	NN
cord-006664-ykfvbypo	410	1	Angiotensin	Angiotensin	NNP
cord-006664-ykfvbypo	410	2	II	II	NNP
cord-006664-ykfvbypo	410	3	induces	induce	VBZ
cord-006664-ykfvbypo	410	4	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	410	5	of	of	IN
cord-006664-ykfvbypo	410	6	adult	adult	NN
cord-006664-ykfvbypo	410	7	ventricular	ventricular	JJ
cord-006664-ykfvbypo	410	8	myocytes	myocyte	NNS
cord-006664-ykfvbypo	410	9	in	in	IN
cord-006664-ykfvbypo	410	10	vitro	vitro	FW
cord-006664-ykfvbypo	410	11	Evidence	evidence	NN
cord-006664-ykfvbypo	410	12	of	of	IN
cord-006664-ykfvbypo	410	13	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	410	14	in	in	IN
cord-006664-ykfvbypo	410	15	arrhythmogenic	arrhythmogenic	NNP
cord-006664-ykfvbypo	410	16	right	right	JJ
cord-006664-ykfvbypo	410	17	ventricular	ventricular	JJ
cord-006664-ykfvbypo	410	18	failure	failure	NN
cord-006664-ykfvbypo	411	1	Cytokine	cytokine	NN
cord-006664-ykfvbypo	411	2	mRNA	mRNA	NNP
cord-006664-ykfvbypo	411	3	expression	expression	NN
cord-006664-ykfvbypo	411	4	in	in	IN
cord-006664-ykfvbypo	411	5	post	post	JJ
cord-006664-ykfvbypo	411	6	-	-	JJ
cord-006664-ykfvbypo	411	7	ischaemic	ischaemic	JJ
cord-006664-ykfvbypo	411	8	/	/	SYM
cord-006664-ykfvbypo	411	9	reperfused	reperfused	JJ
cord-006664-ykfvbypo	411	10	myocardium	myocardium	NN
cord-006664-ykfvbypo	411	11	Serum	serum	NN
cord-006664-ykfvbypo	411	12	interleukin-6	interleukin-6	NNP
cord-006664-ykfvbypo	411	13	levels	level	NNS
cord-006664-ykfvbypo	411	14	become	become	VBP
cord-006664-ykfvbypo	411	15	elevated	elevated	JJ
cord-006664-ykfvbypo	411	16	in	in	IN
cord-006664-ykfvbypo	411	17	acute	acute	JJ
cord-006664-ykfvbypo	411	18	myocardial	myocardial	JJ
cord-006664-ykfvbypo	411	19	infarction	infarction	NN
cord-006664-ykfvbypo	411	20	Elevated	elevate	VBN
cord-006664-ykfvbypo	411	21	circulating	circulating	JJ
cord-006664-ykfvbypo	411	22	levels	level	NNS
cord-006664-ykfvbypo	411	23	of	of	IN
cord-006664-ykfvbypo	411	24	tumour	tumour	NN
cord-006664-ykfvbypo	411	25	necrosis	necrosis	NN
cord-006664-ykfvbypo	411	26	factor	factor	NN
cord-006664-ykfvbypo	411	27	-	-	HYPH
cord-006664-ykfvbypo	411	28	alpha	alpha	NN
cord-006664-ykfvbypo	411	29	in	in	IN
cord-006664-ykfvbypo	411	30	severe	severe	JJ
cord-006664-ykfvbypo	411	31	chronic	chronic	JJ
cord-006664-ykfvbypo	411	32	heart	heart	NN
cord-006664-ykfvbypo	411	33	failure	failure	NN
cord-006664-ykfvbypo	412	1	Oxidative	oxidative	JJ
cord-006664-ykfvbypo	412	2	stress	stress	NN
cord-006664-ykfvbypo	412	3	activates	activate	VBZ
cord-006664-ykfvbypo	412	4	extracellular	extracellular	JJ
cord-006664-ykfvbypo	412	5	signal	signal	NN
cord-006664-ykfvbypo	412	6	-	-	HYPH
cord-006664-ykfvbypo	412	7	regulated	regulate	VBN
cord-006664-ykfvbypo	412	8	kinases	kinase	NNS
cord-006664-ykfvbypo	412	9	through	through	IN
cord-006664-ykfvbypo	412	10	src	src	NNP
cord-006664-ykfvbypo	412	11	and	and	CC
cord-006664-ykfvbypo	412	12	ras	ras	NNP
cord-006664-ykfvbypo	412	13	in	in	IN
cord-006664-ykfvbypo	412	14	cultured	cultured	JJ
cord-006664-ykfvbypo	412	15	cardiac	cardiac	JJ
cord-006664-ykfvbypo	412	16	myocytes	myocyte	NNS
cord-006664-ykfvbypo	412	17	of	of	IN
cord-006664-ykfvbypo	412	18	neonatal	neonatal	JJ
cord-006664-ykfvbypo	412	19	rats	rat	NNS
cord-006664-ykfvbypo	413	1	Myocardial	myocardial	JJ
cord-006664-ykfvbypo	413	2	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	413	3	injury	injury	NN
cord-006664-ykfvbypo	413	4	:	:	:
cord-006664-ykfvbypo	413	5	role	role	NN
cord-006664-ykfvbypo	413	6	of	of	IN
cord-006664-ykfvbypo	413	7	oxygen	oxygen	NN
cord-006664-ykfvbypo	413	8	radicals	radical	NNS
cord-006664-ykfvbypo	413	9	and	and	CC
cord-006664-ykfvbypo	413	10	potential	potential	JJ
cord-006664-ykfvbypo	413	11	therapy	therapy	NN
cord-006664-ykfvbypo	413	12	with	with	IN
cord-006664-ykfvbypo	413	13	antioxidants	antioxidant	NNS
cord-006664-ykfvbypo	413	14	Evidence	evidence	NN
cord-006664-ykfvbypo	413	15	for	for	IN
cord-006664-ykfvbypo	413	16	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	413	17	in	in	IN
cord-006664-ykfvbypo	413	18	advanced	advanced	JJ
cord-006664-ykfvbypo	413	19	human	human	JJ
cord-006664-ykfvbypo	413	20	atheroma	atheroma	NN
cord-006664-ykfvbypo	413	21	:	:	:
cord-006664-ykfvbypo	413	22	co	co	NN
cord-006664-ykfvbypo	413	23	-	-	NN
cord-006664-ykfvbypo	413	24	localization	localization	NN
cord-006664-ykfvbypo	413	25	with	with	IN
cord-006664-ykfvbypo	413	26	interleukin-1-(-converting	interleukin-1-(-converting	.
cord-006664-ykfvbypo	414	1	enzyme	enzyme	NNP
cord-006664-ykfvbypo	414	2	Apoptosis	apoptosis	NN
cord-006664-ykfvbypo	414	3	of	of	IN
cord-006664-ykfvbypo	414	4	human	human	JJ
cord-006664-ykfvbypo	414	5	vascular	vascular	JJ
cord-006664-ykfvbypo	414	6	smooth	smooth	JJ
cord-006664-ykfvbypo	414	7	muscle	muscle	NN
cord-006664-ykfvbypo	414	8	cells	cell	NNS
cord-006664-ykfvbypo	414	9	derived	derive	VBN
cord-006664-ykfvbypo	414	10	from	from	IN
cord-006664-ykfvbypo	414	11	normal	normal	JJ
cord-006664-ykfvbypo	414	12	vessels	vessel	NNS
cord-006664-ykfvbypo	414	13	and	and	CC
cord-006664-ykfvbypo	414	14	coronary	coronary	JJ
cord-006664-ykfvbypo	414	15	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	414	16	plaques	plaque	NNS
cord-006664-ykfvbypo	415	1	Necrosis	necrosis	NN
cord-006664-ykfvbypo	415	2	and	and	CC
cord-006664-ykfvbypo	415	3	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	415	4	induced	induce	VBN
cord-006664-ykfvbypo	415	5	by	by	IN
cord-006664-ykfvbypo	415	6	oxidized	oxidize	VBN
cord-006664-ykfvbypo	415	7	low	low	JJ
cord-006664-ykfvbypo	415	8	density	density	NN
cord-006664-ykfvbypo	415	9	lipoproteins	lipoprotein	NNS
cord-006664-ykfvbypo	415	10	occurs	occur	VBZ
cord-006664-ykfvbypo	415	11	through	through	IN
cord-006664-ykfvbypo	415	12	two	two	CD
cord-006664-ykfvbypo	415	13	calcium	calcium	NN
cord-006664-ykfvbypo	415	14	dependant	dependant	JJ
cord-006664-ykfvbypo	415	15	pathways	pathway	NNS
cord-006664-ykfvbypo	415	16	in	in	IN
cord-006664-ykfvbypo	415	17	lymphoblastoid	lymphoblastoid	NNP
cord-006664-ykfvbypo	415	18	pathways	pathway	NNS
cord-006664-ykfvbypo	415	19	Role	role	NN
cord-006664-ykfvbypo	415	20	of	of	IN
cord-006664-ykfvbypo	415	21	oxidized	oxidize	VBN
cord-006664-ykfvbypo	415	22	low	low	JJ
cord-006664-ykfvbypo	415	23	density	density	NN
cord-006664-ykfvbypo	415	24	lipoprotein	lipoprotein	NN
cord-006664-ykfvbypo	415	25	in	in	IN
cord-006664-ykfvbypo	415	26	atherogenesis	atherogenesis	NNP
cord-006664-ykfvbypo	416	1	The	the	DT
cord-006664-ykfvbypo	416	2	oxidation	oxidation	NN
cord-006664-ykfvbypo	416	3	hypothesis	hypothesis	NN
cord-006664-ykfvbypo	416	4	of	of	IN
cord-006664-ykfvbypo	416	5	atherosclerosis	atherosclerosis	NN
cord-006664-ykfvbypo	416	6	Suppression	suppression	NN
cord-006664-ykfvbypo	416	7	of	of	IN
cord-006664-ykfvbypo	416	8	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	416	9	by	by	IN
cord-006664-ykfvbypo	416	10	nitric	nitric	NN
cord-006664-ykfvbypo	416	11	oxide	oxide	NN
cord-006664-ykfvbypo	416	12	via	via	IN
cord-006664-ykfvbypo	416	13	inhibition	inhibition	NN
cord-006664-ykfvbypo	416	14	of	of	IN
cord-006664-ykfvbypo	416	15	interleukin	interleukin	NN
cord-006664-ykfvbypo	416	16	-	-	HYPH
cord-006664-ykfvbypo	416	17	l	l	NN
cord-006664-ykfvbypo	416	18	beta	beta	NN
cord-006664-ykfvbypo	416	19	converting	convert	VBG
cord-006664-ykfvbypo	416	20	enzyme(ICE)-like	enzyme(ICE)-like	NNP
cord-006664-ykfvbypo	416	21	and	and	CC
cord-006664-ykfvbypo	416	22	cysteine	cysteine	NN
cord-006664-ykfvbypo	416	23	protease	protease	NN
cord-006664-ykfvbypo	416	24	protein	protein	NN
cord-006664-ykfvbypo	417	1	(	(	-LRB-
cord-006664-ykfvbypo	417	2	CPP)-32-like	cpp)-32-like	IN
cord-006664-ykfvbypo	417	3	proteases	protease	NNS
cord-006664-ykfvbypo	417	4	L	l	NN
cord-006664-ykfvbypo	417	5	-	-	HYPH
cord-006664-ykfvbypo	417	6	arginine	arginine	NN
cord-006664-ykfvbypo	417	7	prevents	prevent	VBZ
cord-006664-ykfvbypo	417	8	xanthoma	xanthoma	NNP
cord-006664-ykfvbypo	417	9	development	development	NN
cord-006664-ykfvbypo	417	10	and	and	CC
cord-006664-ykfvbypo	417	11	inhibits	inhibit	VBZ
cord-006664-ykfvbypo	417	12	atherosclerosis	atherosclerosis	NN
cord-006664-ykfvbypo	417	13	in	in	IN
cord-006664-ykfvbypo	417	14	LDL	LDL	NNP
cord-006664-ykfvbypo	417	15	receptor	receptor	NN
cord-006664-ykfvbypo	417	16	knockout	knockout	NN
cord-006664-ykfvbypo	417	17	mice	mice	NN
cord-006664-ykfvbypo	417	18	Core	core	NN
cord-006664-ykfvbypo	417	19	pathology	pathology	NN
cord-006664-ykfvbypo	417	20	lab	lab	NN
cord-006664-ykfvbypo	417	21	findings	finding	NNS
cord-006664-ykfvbypo	417	22	in	in	IN
cord-006664-ykfvbypo	417	23	425	425	CD
cord-006664-ykfvbypo	417	24	patients	patient	NNS
cord-006664-ykfvbypo	417	25	undergoing	undergo	VBG
cord-006664-ykfvbypo	417	26	directional	directional	JJ
cord-006664-ykfvbypo	417	27	atherectomy	atherectomy	NN
cord-006664-ykfvbypo	417	28	for	for	IN
cord-006664-ykfvbypo	417	29	a	a	DT
cord-006664-ykfvbypo	417	30	primary	primary	JJ
cord-006664-ykfvbypo	417	31	coronary	coronary	JJ
cord-006664-ykfvbypo	417	32	artery	artery	NN
cord-006664-ykfvbypo	417	33	stenosis	stenosis	NN
cord-006664-ykfvbypo	417	34	and	and	CC
cord-006664-ykfvbypo	417	35	relationship	relationship	NN
cord-006664-ykfvbypo	417	36	to	to	IN
cord-006664-ykfvbypo	417	37	subsequent	subsequent	JJ
cord-006664-ykfvbypo	417	38	outcome	outcome	NN
cord-006664-ykfvbypo	417	39	:	:	:
cord-006664-ykfvbypo	418	1	the	the	DT
cord-006664-ykfvbypo	418	2	CAVEAT	CAVEAT	NNP
cord-006664-ykfvbypo	418	3	study	study	NN
cord-006664-ykfvbypo	418	4	Integrins	Integrins	NNP
cord-006664-ykfvbypo	418	5	and	and	CC
cord-006664-ykfvbypo	418	6	anoikis	anoikis	NNP
cord-006664-ykfvbypo	418	7	Disruption	Disruption	NNP
cord-006664-ykfvbypo	418	8	of	of	IN
cord-006664-ykfvbypo	418	9	endothelial	endothelial	JJ
cord-006664-ykfvbypo	418	10	cell	cell	NN
cord-006664-ykfvbypo	418	11	matrix	matrix	NN
cord-006664-ykfvbypo	418	12	interactions	interaction	NNS
cord-006664-ykfvbypo	418	13	induces	induce	VBZ
cord-006664-ykfvbypo	418	14	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	418	15	Proliferative	Proliferative	NNP
cord-006664-ykfvbypo	418	16	activity	activity	NN
cord-006664-ykfvbypo	418	17	in	in	IN
cord-006664-ykfvbypo	418	18	peripheral	peripheral	JJ
cord-006664-ykfvbypo	418	19	and	and	CC
cord-006664-ykfvbypo	418	20	coronary	coronary	JJ
cord-006664-ykfvbypo	418	21	atherosclerotic	atherosclerotic	JJ
cord-006664-ykfvbypo	418	22	plaque	plaque	NN
cord-006664-ykfvbypo	418	23	among	among	IN
cord-006664-ykfvbypo	418	24	patients	patient	NNS
cord-006664-ykfvbypo	418	25	undergoing	undergo	VBG
cord-006664-ykfvbypo	418	26	percutaneous	percutaneous	JJ
cord-006664-ykfvbypo	418	27	revascularization	revascularization	NN
cord-006664-ykfvbypo	418	28	Heat	Heat	NNP
cord-006664-ykfvbypo	418	29	shock	shock	NN
cord-006664-ykfvbypo	418	30	induces	induce	VBZ
cord-006664-ykfvbypo	418	31	IkappaB	IkappaB	NNP
cord-006664-ykfvbypo	418	32	-	-	HYPH
cord-006664-ykfvbypo	418	33	alpha	alpha	NN
cord-006664-ykfvbypo	418	34	and	and	CC
cord-006664-ykfvbypo	418	35	prevents	prevent	VBZ
cord-006664-ykfvbypo	419	1	stress	stress	NN
cord-006664-ykfvbypo	419	2	-	-	HYPH
cord-006664-ykfvbypo	419	3	induced	induce	VBN
cord-006664-ykfvbypo	419	4	endothelial	endothelial	JJ
cord-006664-ykfvbypo	419	5	cell	cell	NN
cord-006664-ykfvbypo	419	6	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	419	7	Kinetics	kinetic	NNS
cord-006664-ykfvbypo	419	8	of	of	IN
cord-006664-ykfvbypo	419	9	cellular	cellular	JJ
cord-006664-ykfvbypo	419	10	proliferation	proliferation	NN
cord-006664-ykfvbypo	419	11	after	after	IN
cord-006664-ykfvbypo	419	12	arterial	arterial	JJ
cord-006664-ykfvbypo	419	13	injury	injury	NN
cord-006664-ykfvbypo	419	14	,	,	,
cord-006664-ykfvbypo	419	15	l	l	NN
cord-006664-ykfvbypo	419	16	:	:	:
cord-006664-ykfvbypo	419	17	smooth	smooth	JJ
cord-006664-ykfvbypo	419	18	muscle	muscle	NN
cord-006664-ykfvbypo	419	19	growth	growth	NN
cord-006664-ykfvbypo	419	20	in	in	IN
cord-006664-ykfvbypo	419	21	the	the	DT
cord-006664-ykfvbypo	419	22	absence	absence	NN
cord-006664-ykfvbypo	419	23	of	of	IN
cord-006664-ykfvbypo	419	24	endothelium	endothelium	NN
cord-006664-ykfvbypo	419	25	NF	nf	NN
cord-006664-ykfvbypo	419	26	-	-	HYPH
cord-006664-ykfvbypo	419	27	kB	kB	NNP
cord-006664-ykfvbypo	419	28	is	be	VBZ
cord-006664-ykfvbypo	419	29	induced	induce	VBN
cord-006664-ykfvbypo	419	30	in	in	IN
cord-006664-ykfvbypo	419	31	the	the	DT
cord-006664-ykfvbypo	419	32	nuclei	nucleus	NNS
cord-006664-ykfvbypo	419	33	of	of	IN
cord-006664-ykfvbypo	419	34	cultured	cultured	JJ
cord-006664-ykfvbypo	419	35	rat	rat	NN
cord-006664-ykfvbypo	419	36	aortic	aortic	JJ
cord-006664-ykfvbypo	419	37	smooth	smooth	JJ
cord-006664-ykfvbypo	419	38	muscle	muscle	NN
cord-006664-ykfvbypo	419	39	cells	cell	NNS
cord-006664-ykfvbypo	419	40	by	by	IN
cord-006664-ykfvbypo	419	41	stimulation	stimulation	NN
cord-006664-ykfvbypo	419	42	of	of	IN
cord-006664-ykfvbypo	419	43	various	various	JJ
cord-006664-ykfvbypo	419	44	growth	growth	NN
cord-006664-ykfvbypo	419	45	factors	factor	NNS
cord-006664-ykfvbypo	419	46	Complex	complex	JJ
cord-006664-ykfvbypo	419	47	causes	cause	NNS
cord-006664-ykfvbypo	419	48	of	of	IN
cord-006664-ykfvbypo	419	49	fatal	fatal	JJ
cord-006664-ykfvbypo	419	50	myocardial	myocardial	JJ
cord-006664-ykfvbypo	419	51	infarction	infarction	NN
cord-006664-ykfvbypo	419	52	Use	use	NN
cord-006664-ykfvbypo	419	53	of	of	IN
cord-006664-ykfvbypo	419	54	human	human	JJ
cord-006664-ykfvbypo	419	55	tissue	tissue	NN
cord-006664-ykfvbypo	419	56	specimens	specimen	NNS
cord-006664-ykfvbypo	419	57	obtained	obtain	VBN
cord-006664-ykfvbypo	419	58	by	by	IN
cord-006664-ykfvbypo	419	59	directional	directional	JJ
cord-006664-ykfvbypo	419	60	atherectomy	atherectomy	NN
cord-006664-ykfvbypo	419	61	to	to	TO
cord-006664-ykfvbypo	419	62	study	study	VB
cord-006664-ykfvbypo	419	63	restenosis	restenosis	NN
cord-006664-ykfvbypo	419	64	Histopathology	Histopathology	NNP
cord-006664-ykfvbypo	419	65	of	of	IN
cord-006664-ykfvbypo	419	66	instent	instent	NNP
cord-006664-ykfvbypo	419	67	restenosis	restenosis	NN
cord-006664-ykfvbypo	419	68	in	in	IN
cord-006664-ykfvbypo	419	69	patients	patient	NNS
cord-006664-ykfvbypo	419	70	with	with	IN
cord-006664-ykfvbypo	419	71	peripheral	peripheral	JJ
cord-006664-ykfvbypo	419	72	artery	artery	NN
cord-006664-ykfvbypo	419	73	disease	disease	NN
cord-006664-ykfvbypo	419	74	Reduction	Reduction	NNP
cord-006664-ykfvbypo	419	75	of	of	IN
cord-006664-ykfvbypo	419	76	restenosis	restenosis	NN
cord-006664-ykfvbypo	419	77	after	after	IN
cord-006664-ykfvbypo	419	78	angioplasty	angioplasty	NN
cord-006664-ykfvbypo	419	79	in	in	IN
cord-006664-ykfvbypo	419	80	an	an	DT
cord-006664-ykfvbypo	419	81	atheromatous	atheromatous	JJ
cord-006664-ykfvbypo	419	82	rabbit	rabbit	NN
cord-006664-ykfvbypo	419	83	model	model	NN
cord-006664-ykfvbypo	419	84	by	by	IN
cord-006664-ykfvbypo	419	85	suicide	suicide	NN
cord-006664-ykfvbypo	419	86	gene	gene	NN
cord-006664-ykfvbypo	419	87	therapy	therapy	NN
cord-006664-ykfvbypo	419	88	Involvement	Involvement	NNP
cord-006664-ykfvbypo	419	89	of	of	IN
cord-006664-ykfvbypo	419	90	CD95	CD95	NNP
cord-006664-ykfvbypo	419	91	/	/	SYM
cord-006664-ykfvbypo	419	92	Apo-1	Apo-1	NNP
cord-006664-ykfvbypo	419	93	/	/	SYM
cord-006664-ykfvbypo	419	94	Fas	Fas	NNP
cord-006664-ykfvbypo	419	95	in	in	IN
cord-006664-ykfvbypo	419	96	cell	cell	NN
cord-006664-ykfvbypo	419	97	death	death	NN
cord-006664-ykfvbypo	419	98	after	after	IN
cord-006664-ykfvbypo	419	99	myocardial	myocardial	JJ
cord-006664-ykfvbypo	419	100	infarction	infarction	NN
cord-006664-ykfvbypo	419	101	Inhibition	inhibition	NN
cord-006664-ykfvbypo	419	102	of	of	IN
cord-006664-ykfvbypo	419	103	apoptosis	apoptosis	NN
cord-006664-ykfvbypo	419	104	induced	induce	VBN
cord-006664-ykfvbypo	419	105	by	by	IN
cord-006664-ykfvbypo	419	106	ischaemia	ischaemia	JJ
cord-006664-ykfvbypo	419	107	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	419	108	prevents	prevent	VBZ
cord-006664-ykfvbypo	419	109	inflammation	inflammation	NN
cord-006664-ykfvbypo	420	1	The	the	DT
cord-006664-ykfvbypo	420	2	cardiac	cardiac	JJ
cord-006664-ykfvbypo	420	3	Fas	Fas	NNP
cord-006664-ykfvbypo	420	4	(	(	-LRB-
cord-006664-ykfvbypo	420	5	APO-1	APO-1	NNP
cord-006664-ykfvbypo	420	6	/	/	SYM
cord-006664-ykfvbypo	420	7	CD95	CD95	NNP
cord-006664-ykfvbypo	420	8	)	)	-RRB-
cord-006664-ykfvbypo	420	9	receptor	receptor	NN
cord-006664-ykfvbypo	420	10	/	/	SYM
cord-006664-ykfvbypo	420	11	Fas	Fas	NNP
cord-006664-ykfvbypo	420	12	ligand	ligand	NN
cord-006664-ykfvbypo	420	13	system	system	NN
cord-006664-ykfvbypo	420	14	Tumour	tumour	NN
cord-006664-ykfvbypo	420	15	necrosis	necrosis	NN
cord-006664-ykfvbypo	420	16	factor-	factor-	XX
cord-006664-ykfvbypo	420	17	(	(	-LRB-
cord-006664-ykfvbypo	420	18	contributes	contribute	VBZ
cord-006664-ykfvbypo	420	19	to	to	IN
cord-006664-ykfvbypo	420	20	ischaemia	ischaemia	NN
cord-006664-ykfvbypo	420	21	-	-	:
cord-006664-ykfvbypo	420	22	and	and	CC
cord-006664-ykfvbypo	420	23	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	420	24	induced	induce	VBD
cord-006664-ykfvbypo	420	25	endothelial	endothelial	JJ
cord-006664-ykfvbypo	420	26	dysfunction	dysfunction	NN
cord-006664-ykfvbypo	420	27	in	in	IN
cord-006664-ykfvbypo	420	28	isolated	isolated	JJ
cord-006664-ykfvbypo	420	29	hearts	heart	NNS
cord-006664-ykfvbypo	420	30	Two	two	CD
cord-006664-ykfvbypo	420	31	distinct	distinct	JJ
cord-006664-ykfvbypo	420	32	cytokines	cytokine	NNS
cord-006664-ykfvbypo	420	33	released	release	VBN
cord-006664-ykfvbypo	420	34	from	from	IN
cord-006664-ykfvbypo	420	35	a	a	DT
cord-006664-ykfvbypo	420	36	human	human	JJ
cord-006664-ykfvbypo	420	37	aminoacyl	aminoacyl	NNP
cord-006664-ykfvbypo	420	38	-	-	HYPH
cord-006664-ykfvbypo	420	39	t	t	NNP
cord-006664-ykfvbypo	420	40	-	-	HYPH
cord-006664-ykfvbypo	420	41	RNA	RNA	NNP
cord-006664-ykfvbypo	420	42	synthase	synthase	NN
cord-006664-ykfvbypo	420	43	Pro	pro	JJ
cord-006664-ykfvbypo	420	44	and	and	CC
cord-006664-ykfvbypo	420	45	antiinflammatory	antiinflammatory	JJ
cord-006664-ykfvbypo	420	46	mechanisms	mechanism	NNS
cord-006664-ykfvbypo	420	47	in	in	IN
cord-006664-ykfvbypo	420	48	renal	renal	JJ
cord-006664-ykfvbypo	420	49	reperfusion	reperfusion	NN
cord-006664-ykfvbypo	420	50	in	in	IN
cord-006664-ykfvbypo	420	51	mice	mouse	NNS
cord-006664-ykfvbypo	420	52	:	:	:
cord-006664-ykfvbypo	420	53	modulation	modulation	NN
cord-006664-ykfvbypo	420	54	by	by	IN
cord-006664-ykfvbypo	420	55	endogenous	endogenous	JJ
cord-006664-ykfvbypo	420	56	tumour	tumour	NN
cord-006664-ykfvbypo	420	57	necrosis	necrosis	NN
cord-006664-ykfvbypo	420	58	factor	factor	NN
cord-006664-ykfvbypo	420	59	alpha	alpha	NN
cord-006664-ykfvbypo	420	60	and	and	CC
cord-006664-ykfvbypo	420	61	interleukin	interleukin	NN
cord-006664-ykfvbypo	420	62	10	10	CD