id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-346450-x1u567ss	del Fresno, Carlos	Myeloid cells in sensing of tissue damage	2020-10-07		.txt	text/plain	4209	222	34	During tissue injury, mitochondrial DNA (mtDNA) is also released extracellularly as a pro-inflammatory DAMP [16] that is primarily recognized by the endosomal Toll-Like Receptor 9 (TLR9) upon phagocytosis by myeloid cells [17] . In a similar way, histones released upon cell death are recognized by 36 Innate immunity Inflammatory and regulatory functions of myeloid receptors and DAMPs compiled in this review. During most of the conditions described before, the recognition of DAMPs by myeloid cells triggers direct inflammatory responses by activating signaling pathways downstream certain PRRs. However, the sensing of tissue injury is not always inflammatory but can rather regulate inflammation (Figure 1, right oval) . Tissue injury conditions lead to massive release of different DAMPs. As discussed in here, the recognition of this tissue damage by myeloid cells can generate both pro-inflammatory and regulatory responses.	./cache/cord-346450-x1u567ss.txt	./txt/cord-346450-x1u567ss.txt