id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-345903-ggkn1w5y	Revathidevi, Sundaramoorthy	APOBEC: A molecular driver in cervical cancer pathogenesis	2020-10-07		.txt	text/plain	7008	366	44	In general, APOBEC3 enzymes play a pivotal role in the deamination of cytidines to uracil in DNA and RNA to control diverse biological processes such as regulation of protein expression, innate immunity, and embryonic development. Innate antiviral activity of the APOBEC3 family members restrict retroviruses, endogenous retro-element, and DNA viruses including the HPV that is the leading risk factor for cervical cancer. Most HPV infections are cleared within months by the immune system but a few high-risk subtypes like HPV16 and HPV18 persist and express viral oncogenes E6 and E7 which lead to increased genomic instability, accumulation of somatic mutations, and integration of HPV into the host genome resulting in cervical cancer [3] . In relevance to persistent HPV infection and cervical carcinogenesis, a family of APOBEC enzymes with DNA/RNA editing capability has been analyzed as they are involved in various immune functions including restriction of viral replication, antigen presentation, and maturation of host immune receptors and are highly polymorphic in nature [79] .	./cache/cord-345903-ggkn1w5y.txt	./txt/cord-345903-ggkn1w5y.txt