id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341062-k3vjqumq	Pruitt, Hawley C.	Roles of N‐Myc and STAT interactor in cancer: From initiation to dissemination	2016-03-11		.txt	text/plain	6635	409	47	N‐myc & STAT Interactor, NMI, is a protein that has mostly been studied for its physical interactions with transcription factors that play critical roles in tumor growth, progression and metastasis. The physical interactions of NMI with its binding partners have been linked to many aspects of tumor biology including DNA damage response, cell death, epithelial‐to‐mesenchymal transition and stemness. 45 NMI expression reversed mesenchymal phenotypes of highly invasive breast cancer cells through enhancing STAT5-mediated transcription of SMAD7. Tri-complex formation leads to the stabilization of cytosolic b-catenin, a transcriptional co-factor that can enter the nucleus, bind to a member of the TCF/LEF protein family and subsequently activate transcription of Wnt target genes. Stably expressing NMI in MDA-MB-231 and MDA-MB-435 cancer cell lines led to increased levels of DKK1 and concomitantly reduced levels of b-catenin and c-Myc, known downstream targets of Wnt signaling.	./cache/cord-341062-k3vjqumq.txt	./txt/cord-341062-k3vjqumq.txt