id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-338633-pxxon1ni	Zuo, Yu	Neutrophil extracellular traps and thrombosis in COVID-19	2020-11-05		.txt	text/plain	2782	167	41	We found that remnants of NETs (cell-free DNA, myeloperoxidase-DNA complexes, and citrullinated histone H3) and neutrophil-derived S100A8/A9 (calprotectin) in patient sera were associated with higher risk of morbid thrombotic events in spite of prophylactic anticoagulation. Neutrophil-derived extracellular traps (NETs) play a pathogenic role in many thrombo-inflammatory states including sepsis [4, 5] , thrombosis [6] [7] [8] , and respiratory failure [9, 10] . Here, we describe 11 cases of thrombosis in patients hospitalized with COVID-19 and demonstrate an association with neutrophil hyperactivity and NET release. As compared with the control group, patients with a thrombotic event demonstrated significantly higher levels of calprotectin, a marker of neutrophil activation (Fig. 1a) . Finally, we asked whether there was an association between blood markers of neutrophil activation (such as calprotectin and cell-free DNA) and D-dimer within this cohort of COVID-19 patients (n = 44).	./cache/cord-338633-pxxon1ni.txt	./txt/cord-338633-pxxon1ni.txt