id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336749-qbko22vf	Kalisch, Thomas	New readers and interpretations of poly(ADP-ribosyl)ation	2012-09-30		.txt	text/plain	6658	304	44	MacroH2A1.1, which is involved in the DNA damage response and transcriptional regulation, is able to bind PAR, ADPR and the SirT1 metabolite O-acetyl-ADP-ribose (OAADPR), which is produced during the NAD + -dependent deacetylation of acetylated proteins [22] . RNF146 is rapidly recruited to laser-induced DNA-damaged sites; its PAR-dependent E3 ligase activity promotes DNA repair and prevents cell death induced by g-irradiation, alkylating agents or hydrogen peroxide, but only at doses known to trigger cell death superfamily C-terminal domain associated with DEXDc-, DEAD-and DEAH-box proteins (lavender box); FHA, forkhead associated (light pink box); HECT, homologous to E6-AP carboxyl terminus domain, displaying E3-ligase activity (light orange box); lactamase B, domain homologous to b-lactamase endowed with nuclease activity (gray box); macro, homologous to the nonhistone part of macroH2A, displaying PAR-binding activity (see text; blue box); PARP, catalytic domain, homologous to the poly(ADP-ribose) synthesis domain of PARP-1, endowed with mono-or poly(ADP-ribosyl)ation activity (green box); PBZ, PAR-binding zinc finger (see text; orange box); RING, really interesting new gene: zinc binding domain with ubiquitin E3 ligase activity (sienna box); SAM-L, sterile a motif-like (purple box); SNF2-N, SNF2 family N-terminal domain (light steel blue box); UBA, ubiquitin-binding domain (silver gray box); WWE, named after its three conserved residues Trp, Trp and Glu, displaying PAR-binding activity (see text; dark yellow box); Zf-CCCH, zinc finger motif (pink box).	./cache/cord-336749-qbko22vf.txt	./txt/cord-336749-qbko22vf.txt