id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336219-xndxn1r3	Chuang, Chi-Mu	Treatment with Imiquimod enhances antitumor immunity induced by therapeutic HPV DNA vaccination	2010-04-28		.txt	text/plain	4726	246	54	METHODS: In the current study, we explored the combination of the DNA vaccine encoding calreticulin (CRT) linked to human papillomavirus type 16 (HPV-16) E7 antigen (CRT/E7) with the TLR7 agonist imiquimod for their ability to generate E7-specific immune responses and antitumor effects in tumor-bearing mice. RESULTS: We observed that treatment with CRT/E7 DNA in combination with imiquimod leads to an enhancement in the E7-specific CD8+ T cell immune responses and a decrease in the number of myeloid-derived suppressor cells in the tumor microenvironment of tumor-bearing mice. In the current study, we hypothesize that the combination of the DNA vaccine encoding CRT linked to HPV-16 E7 (CRT/E7) with topical application of imiquimod at the site of the tumor will lead to increased infiltration of effectior immune cells at the site of the tumor, resulting in enhanced antitumor effects against E7-expressing tumors in a preclinical model.	./cache/cord-336219-xndxn1r3.txt	./txt/cord-336219-xndxn1r3.txt