id author title date pages extension mime words sentences flesch summary cache txt cord-331557-8axi74nn Raoult, Didier What does the future hold for clinical microbiology? 2004 .txt text/plain 6513 328 35 When PCR is used to detect DNA in clinical specimens, microarrays can then be used to identify the amplified products by hybridization to an array that is composed of pathogen-specific probes. Kits are available for the detection and quantification of DNA and RNA in clinical samples, and the technique has been specifically developed to enable the follow-up of patients with HIV and hepatitis C infections (Amplitech AME Bioscience; Bayer Diagnostics; Roche Diagnostics). Mass-spectrometry analysis of base-specific fragmentation patterns of PCRamplified DNA has recently been studied as a technique for the rapid identification of bacterial isolates and for the detection of specific 16S rRNA gene fragments that are amplified from complex environmental samples 35 . These automated microarrays will be suitable both for mass screening of sera in epidemiology studies and in blood banks, and for diagnostics that are carried out on single serum samples in clinical microbiology laboratories. ./cache/cord-331557-8axi74nn.txt ./txt/cord-331557-8axi74nn.txt