id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-311349-145kwny3	Mariani, Stefano	Surface plasmon resonance applications in clinical analysis	2014-02-25		.txt	text/plain	13425	630	39	In the last 20 years, surface plasmon resonance (SPR) and its advancement with imaging (SPRi) emerged as a suitable and reliable platform in clinical analysis for label-free, sensitive, and real-time monitoring of biomolecular interactions. The advantages brought about by current SPR technology include real-time monitoring of the analyte/molecular markers, label free and parallel analysis (with SPRi), minimal sample pretreatment, quantitative response, and very good sensitivity and reproducibility, (reported detection limits are in atto-or femtomolar ranges and coefficient of variations below 10 %). Preventing nonspecific adsorption of biomolecules (e.g., protein) on the SPR sensing surface is another key-step for the development of specific biosensor, with real application to clinical diagnostics where complex matrices (such as serum, blood, and urine) are analyzed.	./cache/cord-311349-145kwny3.txt	./txt/cord-311349-145kwny3.txt