id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-298514-l2hs1h9c	Ghosh, Soma	Central Role of Ubiquitination in Genome Maintenance: DNA Replication and Damage Repair	2012-02-08		.txt	text/plain	5360	276	39	The ubiquitin system mediates the DNA damage response to all the above forms of replicative damage in the cell in order to prevent genomic instability and onset of cancer. The checkpoint apparatus targets the CDK regulators like cyclins, CDK inhibitors, or CDC25 family of dual-specificity phosphatases, depending upon the stage of the cell cycle in which the DNA damage has occurred. SCF ßTrCP also regulates checkpoint recovery: the ubiquitin-dependent degradation of CLASPIN (a DNA-binding protein required for the ATR mediated activation of Chk1 in response to DNA replication stress) in G2 allows efficient termination of DNA replication checkpoint which is necessary for progression of the cell into mitosis [36] [37] [38] [39] . Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation	./cache/cord-298514-l2hs1h9c.txt	./txt/cord-298514-l2hs1h9c.txt