id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-296967-qiil3gqk	Tatlow, Dean	A novel concept for treatment and vaccination against Covid‐19 with an inhaled chitosan‐coated DNA vaccine encoding a secreted spike protein portion	2020-08-08		.txt	text/plain	2262	143	52	A novel concept in DNA vaccine design is the creation of an inhaled DNA plasmid construct containing a portion of the coronavirus spike protein for treatment and vaccination. An inhaled plasmid DNA vaccine replicates the route of lung infection taken by coronavirus with transfected cells secreting spike protein portions to induce immunity. 3 These findings of the identified spike proteins in the SARS-CoV-2 receptor binding domain and ACE2 region may provide useful information for treatment or vaccine development. 5 In this paper a series of inhaled plasmid DNA vaccine construct containing various forms of the coronavirus spike protein sequence may provide potential treatment and vaccine options as revealed by Yu et al. 3 Once in the lower respiratory tract or alveolar region of the lung deposited plasmid DNA will be taken up and expression of coronavirus spike proteins by host cells such as pneumocytes will occur.	./cache/cord-296967-qiil3gqk.txt	./txt/cord-296967-qiil3gqk.txt