id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288131-dwhfrgje	Zhao, Guodong	Aberrant DNA Methylation of SEPT9 and SDC2 in Stool Specimens as an Integrated Biomarker for Colorectal Cancer Early Detection	2020-06-18		.txt	text/plain	4309	234	62	A number of methylated DNA biomarkers have been found to associate with CRC and precancerous lesions in stool or plasma samples, including SEPT9 (Catherine et al., 2008; Lamb and Dhillon, 2017) , SDC2 (Barták et al., 2017; Han et al., 2019) , SFRP2 (Barták et al., 2017; Li et al., 2019) , and TFPI2 (Glöckner et al., 2009) , some of which have been developed into commercial kits for CRC early detection (Potter et al., 2014; Lamb and Dhillon, 2017; Li et al., 2019; Zhao et al., 2019) . We previously demonstrated a multiplex methylated DNA test in plasma, ColoDefense test, with high sensitivity and specificity for CRC early detection. Instead, we have demonstrated that the detection rates of plasma ColoDefense test for AA and early stage CRC were significantly improved by the combination of two biomarkers, mSEPT9 and mSDC2, with high specificity .	./cache/cord-288131-dwhfrgje.txt	./txt/cord-288131-dwhfrgje.txt