id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-265764-h4zg0q8x	Singh, Kamaljit	Synthesis of 4-aminoquinoline–pyrimidine hybrids as potent antimalarials and their mode of action studies	2013-06-10		.txt	text/plain	4082	219	49	On the other hand, pyrimidine-based compounds are well known for their wide range of promising antiviral [22] , antitubercular [23] , anti-AIDS [24] , antinociceptive [25] , antifungal [26] , antitumor [27] and antimalarial activities [28] apart from their role in the nucleic acid synthesis. The in vitro antimalarial screening of the new synthesized compounds 5aeg revealed good to moderate activities in nM range against both the tested Dd2 (CQ S ) and D10 strains (CQ R ) of P. Analysis of the activity of the compounds recorded in Table 1 reveals that replacing C-5 ethyl ester of the previously reported [29] decrease in antimalarial activity against both the chloroquine sensitive and chloroquine resistant strains of P. In this study, we have evaluated the mechanism of antimalarial activity of the most potent compound 5b of the series by studying its binding with heme (Fig. 4) .	./cache/cord-265764-h4zg0q8x.txt	./txt/cord-265764-h4zg0q8x.txt