id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-265237-sxh2nqre	Weile, Jan	Current applications and future trends of molecular diagnostics in clinical bacteriology	2009-04-18		.txt	text/plain	4555	226	35	Improvements and new approaches in technology now open the possibility for the development of multiparameter assays using microarrays, multiplex nucleic acid amplification techniques, or mass spectrometry, while the introduction of closed-tube systems has resulted in rapid microbial diagnostics with a subsequently reduced contamination risk. We mainly focus this review on nucleic-acid-based molecular techniques for identification and resistance determination in clinical bacteriology, giving a brief overview of currently used modern bacterial diagnostics and providing an outlook on future technologies, especially dealing with the multiparametric detection of infectious disease-related determinants. With exception of molecular tests such as nucleic acid amplification techniques (NAT), direct microscopy of the specimen, culturing, and direct antigen detection represent the sole possibilities to detect an acute infection as early as possible, facing either a lack of sensitivity, specificity or long time periods until results are available.	./cache/cord-265237-sxh2nqre.txt	./txt/cord-265237-sxh2nqre.txt