id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262353-iips79vo	Veltkamp, Henk-Willem	Disposable DNA Amplification Chips with Integrated Low-Cost Heaters †	2020-02-25		.txt	text/plain	9618	540	57	Based on the analysis of the milling process, metal adhesion studies, and COMSOL MultiPhysics heat transfer simulations, the first batch of chips has been fabricated and successful multiple displacement amplification reactions are performed inside these chips. The work presented at the 4th Microfluidic Handling Systems conference and which is extended in this paper aims at the development of a disposable, polymer-based DNA amplification lab-on-chip system with integrated resistive heater based on the World Health Organization (WHO) Sexually Transmitted Diseases Diagnostics Initiative (SDI) ASSURED criteria. The aim of this study was to fabricate biocompatible, low-cost, and disposable chips with integrated heater, which should be able to perform DNA amplification, and possible in situ fluorescence detection in the near future. The integrated resistive heaters on the chips were characterized and showed a temperature stability of ±2 • C over a time period of 25 h, which is at least twelve-fold longer than the required operating times for DNA amplification reactions [6, [8] [9] [10] [11] .	./cache/cord-262353-iips79vo.txt	./txt/cord-262353-iips79vo.txt