id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-261028-sxux2ujo	Vatner, Ralph E.	STING, DCs and the link between innate and adaptive tumor immunity	2017-12-20		.txt	text/plain	10018	475	44	Dendritic cells (DCs) are a heterogeneous population of professional antigen-presenting cells (APCs) from hematopoietic origin that serve as a key link between the innate and adaptive immune systems, and are the lynchpin in generating anti-tumor immunity (Steinman and Idoyaga, 2010) . More recently, type I IFN production and signaling through the STING pathway has been identified as having an essential role in the development of anti-tumor immunity in response to tumor derived DNA. DNA sensing by STING is the upstream link that triggers type I IFN production by DCs and facilitates effective cross-priming of tumor specific CD8+ T cells. This DNA is likely derived from stressed and dying cancer cells, and is introduced into the DC cytosol through a yet unknown mechanism where it binds to cGAS, which initiates STING mediated type I IFN transcription (Fig. 2) .	./cache/cord-261028-sxux2ujo.txt	./txt/cord-261028-sxux2ujo.txt