id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260050-9ex70e1k	Zhang, Y. Q.	Inhibition of herpes simplex virus type 1 by small interfering RNA	2007-11-02		.txt	text/plain	2120	131	51	Aim. To investigate the antiviral effects of siRNA on herpes simplex virus type 1 (HSV‐1) replication in Vero cells. These results indicate that siRNA can potently inhibit HSV‐1 replication in vitro, suggesting that siRNA‐based antiviral therapy may be a potential effective therapeutic alternative for patients with HSV‐1 infection. In our experiments, we showed that the siRNA duplexes targeting VP16 and DNA polymerase genes potently inhibited HSV-1 replication. However, this is not a universal finding as no additive or synergistic effect on antiviral activity was observed in a study when using any combination between the specific siRNA targeting viral protease 2A and any other siRNAs targeting the 5¢ untranslated region, start codon and RNA polymerase 3D of coxsackie virus B3. Short interfering RNA-mediated inhibition of herpes simplex virus type 1 gene expression and function during infection of human keratinocytes	./cache/cord-260050-9ex70e1k.txt	./txt/cord-260050-9ex70e1k.txt