id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-258665-8q3tsggm	Aydın, Hakan Berk	Pixelated colorimetric nucleic acid assay	2020-03-01		.txt	text/plain	4056	225	45	Herein, we report a pixelated analysis approach for correlating colorimetric responses of CPE with nucleic acid concentrations down to 1 nM, in plasma samples, utilizing a smart phone with an algorithm that can perform analytical testing and data processing. A smart phone application is developed to capture and digitize the colorimetric response of the individual pixels of the digital images of CPE on the PVDF membrane, followed by an analysis using the algorithm. The proposed pixelated approach enables precise quantification of nucleic acid assay concentrations, thereby eliminating the margin of error involved in conventional methodologies adopted for interpretation of colorimetric responses, for instance, RGB analysis. Herein, we propose a smart phone application algorithm that evaluates the colorimetric responses based on a pixel level analysis approach, enabling quantification of nucleic acids with high precision at clinically relevant concentration ranges. A cartridge-based point of care assay for colorimetric detection of nucleic acids has been developed using a smart phone algorithm.	./cache/cord-258665-8q3tsggm.txt	./txt/cord-258665-8q3tsggm.txt