id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-258035-2tk7maqk	DeFilippis, Victor	Functional genomics in virology and antiviral drug discovery	2003-10-31		.txt	text/plain	4769	255	39	Given that virus replication involves use and manipulation of multiple host proteins and molecular processes, cellular pathways related to transcription and translation, signal transduction, metabolism, host defense and cell cycle control are Review commonly altered in response to, or as a result of, infection with diverse virus types. A special case of virus modulation of host cell gene expression in which functional genomics will reveal novel targets and treatments is viral oncogenesis. The most recent method for analyzing gene inhibition studies has been RNAi or siRNA, where small 21 -23-nucleotide (nt) RNA duplexes interfere with the transcription program by directing degradation of homologous mRNA [34] [35] [36] [37] . Both new-generation antisense oligomers and siRNA can be used to knockdown expression of genes that were found by DNA microarrays to be upregulated in virally infected cells or organisms. RNA interference directed against viral and cellular targets inhibits human immunodeficiency virus type 1 replication	./cache/cord-258035-2tk7maqk.txt	./txt/cord-258035-2tk7maqk.txt