id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-258014-lzzi4rnz	Chorna, Nataliya	A Protocol for the Multi-Omic Integration of Cervical Microbiota and Urine Metabolomics to Understand Human Papillomavirus (HPV)-Driven Dysbiosis	2020-04-08		.txt	text/plain	6060	394	47	This methods article suggests detailed sample collection and laboratory processes of metabolomics, DNA extraction for microbiota, HPV typing, and the bioinformatic analyses of the data, both to characterize the metabolome, the microbiota, and joint multi-omic analyses, useful for the development of new point-of-care diagnostic tests based on these approaches. Recent studies have indicated that changes of the cervicovaginal microbiome [5] [6] [7] , such as bacterial vaginosis [8, 9] , cervical inflammation [10, 11] and vaginal pH [12, 13] , play a role in the susceptibility to cervical Human Papillomavirus (HPV) infection and the development of cervical intraepithelial neoplasia due to the profound shifts in the relative abundances of protective bacteria [10] . Derivatization solution without the sample only, and empty vials, must also be included as quality controls in the analysis to ensure that identified metabolites 11.	./cache/cord-258014-lzzi4rnz.txt	./txt/cord-258014-lzzi4rnz.txt