id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255499-31xmue1g	Bujarski, J.J.	Recombination	2008-07-30		.txt	text/plain	4852	253	41	In general, homologous recombination events occur much more often and they are most commonly known as genetic crossing-over that happens in every DNA-based organism during meiosis. The mechanism may involve either homologous crossing-over events or copy-choice processes that rely on template switching by DNA replicase. Aberrant homologous recombination involves crossovers between related RNAs, but the crosses occur at not-corresponding sites leading to sequences insertions or deletions. A double-stranded RNA Pseudomonas phage Phi6 was hypothesized to recombine its RNA based on a copy-choice template switching mechanism, where the crossovers would have occurred inside the virus capsid structures at regions with almost no sequence similarity. In some cases, the base pairing between a partial nascent strand and the acceptor template can lead to the appearance of the rearranged regions in DI RNAs. In addition to rearranged DI RNAs, some RNA viruses accumulate defective RNAs due to a single internal deletion in the genomic RNA of the helper virus.	./cache/cord-255499-31xmue1g.txt	./txt/cord-255499-31xmue1g.txt