id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-253826-63dgq551	Kim, Jisung	State of diagnosing infectious pathogens using colloidal nanomaterials	2017-08-17		.txt	text/plain	10488	535	39	This review article discusses current advances of diagnostic systems using colloidal nanomaterials (e.g., gold nanoparticles, quantum dots, magnetic nanoparticles) for identifying and differentiating infectious pathogens. Similarly, Raman dye labeled oligonucleotide probes have been conjugated to GNPs in a scanometric assay to generate spectroscopic codes for individual target DNA and demonstrate a multiplexed detection (Fig. 6C ). While this technology is still early in development, these results show that thermal contrast may enhance the analytical sensitivity to enable detection of infectious pathogens, which are normally done with more complex molecular diagnostics. For detection of nucleic acids, none of the nanodiagnostic approaches were as sensitive as PCR (zM), except for the Mirkin's bio-barcode assay that utilized magnetic separation, and two levels of signal amplification. As we discussed in this review article, nanoparticles have been exploited to improve the analytical sensitivity of diagnostic assays, provide various readout signals, simultaneously detect multiple targets, and simplify diagnostic procedures.	./cache/cord-253826-63dgq551.txt	./txt/cord-253826-63dgq551.txt