id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-031970-7szpo4zx	Qiao, Yu	Tumorigenic and Immunogenic Properties of Induced Pluripotent Stem Cells: a Promising Cancer Vaccine	2020-09-16		.txt	text/plain	6938	377	39	Finally, the review will discuss the expanding application of iPSC technology in cancer immunotherapy as a potential cancer vaccine and its advantages in auxiliary treatment compared with oncofetal antigen-based and embryonic stem cell (ESC)-based vaccines. While the core pluripotent factors like Oct4, Sox2, Klf4, c-Myc, Nanog and Lin28 are promoting the somatic reprogramming process, one of the vital tumor suppressor gene -P53 acts like a barrier to impede this. Abnormal epigenetic modification accumulated in the iPSCs from reprogramming to prolonged culture also contributes to the risk of tumorigenic potential colon cancer cell line reduced colony formation not because of apoptosis induction, but due to its role in mediating p53dependent cell cycle arrest [66] . Another parallel study demonstrated that iPSC had similar gene expression patterns with lung adenocarcinoma stem cells and could provoke anti-tumor immunity in humanized mice model [154] . Humanized mice reveal differential immunogenicity of cells derived from autologous induced pluripotent stem cells	./cache/cord-031970-7szpo4zx.txt	./txt/cord-031970-7szpo4zx.txt