id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-029462-jm5qwxhz	Ouidir, Marion	Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation	2020-07-13		.txt	text/plain	6383	353	45	We performed an epigenome-wide association study (EWAS) to identify placental DNA methylation associated with maternal plasma concentration of POPs in early gestation (10 weeks 0 days to 13 weeks 6 days) among 260 pregnant women participating in the Eunice Kennedy Shriver National Institute of Child Health and Human Development's (NICHD) Fetal Growth Studies-Singletons cohort (which comprised 2802 pregnant women from 12 clinic sites within the USA). In total, maternal early pregnancy plasma concentrations of POPs were significantly associated with placental DNA methylation at 214 CpG sites annotated to 205 genes (BACON-corrected false discovery rate (FDR) p values < 0.05, nominal p values ranging from 2.61 × 10 −21 to 2.11 10 −7 , Supplementary Table S3 ). The correlations between DNA methylation at the POPs-associated CpG sites and neonatal anthropometry suggest that placental epigenetic mechanisms may underlie the influence of specific maternal plasma POP concentrations on fetal growth.	./cache/cord-029462-jm5qwxhz.txt	./txt/cord-029462-jm5qwxhz.txt