id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-025251-evnfvc0l	Nemunaitis, John	Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection: let the virus be its own demise	2020-05-26		.txt	text/plain	7308	397	38	Herein we describe the rationale and potential of repurposing a dual plasmid, Vigil (pbi-shRNA(furin)-GM-CSF), now in Phase III cancer trials, for the treatment of and, in certain circumstances, enhancement of the immune response to SARS-CoV-2. A recent publication from Nankai University (Tianjin, China) on SARS-CoV-2 reported that genome sequence analysis revealed a section of genes that was not present in SARS-CoV that had a cleavage site similar to HIV and Ebola which carry viral proteins necessary for fusogenic activity of viral species to the human cell membrane. Another immunotherapeutic intervention would be to increase the pulmonary expression of GM-CSF, which, in vivo, redirects macrophages from an M1 state of activation to an M2 activation state and enhances expression of anti-inflammatory mediators and perhaps allow more time for patients to mount an effective immune response against SARS-CoV-2 [25] . Similar to SARS-CoV-2, alveolar epithelial cells are the primary target of influenza virus (IV) and are the first site of entry and support for viral propagation and replication.	./cache/cord-025251-evnfvc0l.txt	./txt/cord-025251-evnfvc0l.txt