id author title date pages extension mime words sentences flesch summary cache txt cord-022476-g826uiqx nan Eosinophils and Anti-Pathogen Host Defense 2012-10-12 .txt text/plain 12501 638 36 Similarly, although the weight of evidence suggests that eosinophils contribute to the pathophysiology of allergy and asthma, a chronic respiratory disease in which bronchoconstriction in response to environmental triggers is typically associated with production of T h 2 cytokines and recruitment of eosinophils to the airways, asthmatic responses are obviously negative sequelae of eosinophil function that alone cannot represent a direct evolutionary advantage to the host organism. Although respiratory virus infections are not among the diseases typically associated with T h 2 lymphocyte activation and profound pulmonary eosinophilia, eosinophils and/or eosinophil granule secretory proteins have been detected in lung washings or systemically in infants in need of supplemental oxygen secondary to severe RSV infection. 55 A number of studies suggest potential detrimental roles for eosinophils and fungi in T h 2-mediated airway diseases, such as allergic bronchopulmonary aspergillosis (ABPA), severe asthma associated with fungal sensitivity (SAFS), and CRS. ./cache/cord-022476-g826uiqx.txt ./txt/cord-022476-g826uiqx.txt