id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-021532-6hmn90ac	Von Seggern, Dan J.	ADENOVIRAL VECTORS FOR PROTEIN EXPRESSION	2007-09-02		.txt	text/plain	12536	580	43	Many features of this viral system, including the ability to infect a wide variety of nondividing cells, a large capacity for insertion of DNA, ease of production and stability of the viral particles, and the high viral titers that can be produced, make Ad-based vectors especially useful in gene transfer. Recombinant adenoviruses have been used to express foreign proteins for a number of years, and the recent explosion of interest in gene therapy has led to the development both of improved adenoviral vectors and of more efficient techniques for generating them. Once constructed, a single vector can be used for in vitro protein expression and purification, studies of the effect of the gene product on cell biology, or in vivo studies in many tissue types and a number of different species. Viral vectors deleted for the corresponding sequences will have a higher capacity for insertion of DNA and should be useful for expressing large proteins such as dystrophin or combinations of genes (perhaps multisubunit enzyme complexes).	./cache/cord-021532-6hmn90ac.txt	./txt/cord-021532-6hmn90ac.txt