id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-018145-kssjdn8y	Niemann, Heiner	Transgenic Farm Animals: Current Status and Perspectives for Agriculture and Biomedicine	2009		.txt	text/plain	9160	503	40	Guidelines developed by the Food and Drug Administration (FDA) of the USA require monitoring the animals' health in a specific pathogen free (SPF) facility, sequence validation of the gene construct, characterization of the isolated recombinant protein, and monitoring the genetic stability of the transgenic animals over several generations. Some gene constructs have failed to produce economically significant amounts of protein in the milk of transgenic animals indicating that the technology needs further refinement to insure consistent high-level expression. The use of somatic nuclear transfer will accelerate production of transgenic animals for mammary gland specific synthesis of recombinant proteins. In the pig, increased transgenic expression of a bovine lactalbumin construct in the mammary gland resulted in increased lactose content and increased milk production which resulted in improved survival and development of the piglets (Wheeler et al.	./cache/cord-018145-kssjdn8y.txt	./txt/cord-018145-kssjdn8y.txt