id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017563-jkhvcjcb	Holland, Tod D.	Modeling Brain Tumors Using Avian Retroviral Gene Transfer	2008-12-12		.txt	text/plain	4703	213	51	Mice bearing RCAS/tv-a-induced brain tumors are currently being used for preclinical trials to understand the biology of therapeutic response in the various cell types that make up gliomas and medulloblastomas. These oncogenes appeared to be stolen from the host genome and then expressed either in the wrong cell type or in an unregulated manner by the virus leading to the formation of cancer (Kurth, 1983) . Gliomas probably form from stem cells or progenitors and are driven by the signaling pathways that drive normal development in the CNS such as PDGF and downstream effectors such as RAS and Akt. The most potent oncogene in the formation of gliomas is the PDGFB ligand . Then SHH gene transfer with RCAS vectors into nestin-expressing cells of the rhombic lip created medulloblastomas in a minority of mice (Rao et al., 2004) .	./cache/cord-017563-jkhvcjcb.txt	./txt/cord-017563-jkhvcjcb.txt