id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017188-d3xg05ty	Swartz, H.M.	Free Radicals and Medicine	2005		.txt	text/plain	15533	799	45	Examples described include pulmonary free radical damage, free radicals and sickle cell disease, free radicals in amyotrophic lateral sclerosis, melanin and free radicals and the potential role of oxidative stress in the induction of cancer. The potential limiting factors for such studies include the technical problems of carrying out EPR measurements in human subjects and‚ for techniques that involve the administration of spin traps or other substances‚ the complex and difficult process for obtaining permission to administer substances to human subjects (Swartz‚ 2003) . The first in vivo spin trapping evidence for increased free radical formation was provided using the SOD1-G93A transgenic mouse model for FALS (Gurney et al.‚ 1998) . In conclusion‚ in vitro and in vivo experiments suggest that nitrone spin traps can potentially mitigate oxidative stress in FALS mutant overexpressing cells and mice and protect against progressive motor neuron death.	./cache/cord-017188-d3xg05ty.txt	./txt/cord-017188-d3xg05ty.txt