id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016304-uusmg786	Lemuth, Karin	Microarrays as Research Tools and Diagnostic Devices	2015-03-11		.txt	text/plain	8577	457	41	Starting from mono-parametric tests within the last years, technologies have evolved that allow for the detection of many parameters in parallel, e.g., by using multiplex nucleic acid amplification techniques, microarrays, or next-generation sequencing technologies. Further, closed lab-on-a-chip devices that use DNA microarrays as detection tools are discussed, and additionally, an outlook toward applications of next-generation sequencing tools in diagnostics will be given. First used for multiparametric transcriptional profiling, the technology rapidly developed toward a tool for the detection of all kinds of biological targets (DNA, RNA, proteins, cells, nucleic acids, carbohydrates, etc.) or their modifications (methylation, phosphorylation, etc.) within the last 20 years. This 70-gene signature has been validated in several clinical trials, in general using fresh biopsy tissue for preparation of the transcriptional profiles during the last years and is now commercially available via Agendia as MammaPrint ® (using Microarrays based on Agilent technology) for guided therapy of early-stage breast cancer (Exner et al.	./cache/cord-016304-uusmg786.txt	./txt/cord-016304-uusmg786.txt