id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016187-58rqc0cg	Opal, S. M.	The Challenge of Emerging Infections and Progressive Antibiotic Resistance	2006		.txt	text/plain	6617	330	37	Community and nosocomial outbreaks of multidrug resistant pathogens as evidenced by methicillin and vancomycin resistance [17] in Staphylococcus aureus and resistance to the new anti-viral neuraminidase inhibitors [18, 19] by recent infl uenza isolates are cause for real concern. Beta-lactam antibiotics have been known for almost 80 years and their widespread use has created selection pressures on bacterial pathogens to resist their inhibitory actions. These investigators discovered that the resistant strain had acquired a new methylase gene that blocked the binding site for inhibition by aminoglycosides on a specifi c sequence on 16S ribosomal RNA. Mutations resulting in the loss of specifi c porins can occur in clinical isolates and determine increased resistance to beta-lactam antibiotics. If we could discover new targets for future antimicrobial drugs it may be possible to keep pace or even exceed the rate of antibiotic resistance gene development by microbial pathogens.	./cache/cord-016187-58rqc0cg.txt	./txt/cord-016187-58rqc0cg.txt