id author title date pages extension mime words sentences flesch summary cache txt cord-016095-jop2rx61 Vignais, Pierre V. Challenges for Experimentation on Living Beings at the Dawn of the 21(st) Century 2010-06-08 .txt text/plain 42843 1503 43 Instead of setting out to discover unknown mechanisms by analyzing effects that are dependent on specific causes, with some uncertainty as to the possible success of the enterprise being undertaken, which is the foundation stone of the Bernardian paradigm of the experimental method, many current research projects give themselves achievable and programmable objectives that depend upon the means available to them: sequencing of genomes with a view to comparing them, recognition of sequence similarities in proteins coded for by genes belonging to different species, with the aim of putting together phylogenetic trees, synthesis of interesting proteins in transgenic animals and plants, analysis of the three-dimensional structure of proteins, in order to find sites that are likely to fix medicinal substances, and synthesis of molecular species able to recognize pathogenic targets. ./cache/cord-016095-jop2rx61.txt ./txt/cord-016095-jop2rx61.txt