id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011630-lfm34fsw	Li, Yan	Epigenetic inheritance of circadian period in clonal cells	2020-05-27		.txt	text/plain	5694	306	43	By examining large-scale phenotype-associated gene expression profiles in hundreds of mouse clonal cell lines, we identified and validated multiple novel candidate genes involved in circadian period determination in the absence of significant genomic variants. Here, by examining phenotype-associated high-throughput multi-omics profiles in clonal cell populations, we identified and validated a pool of novel candidate genes regulating circadian period length and uncovered complex gene co-expression networks highly enriched in stress response and metabolic pathways. Using weighted gene co-expression network analysis (WGCNA), we generated 31 modules from the 10 clonal cell lines RNA-seq data ( Figure 4A , Figure 4 -source data 1). Dnmt1 and Dnmt3a knockdown in the ten clonal cell lines showed the same overall results, suggesting that DNA methylation affects circadian periodicity in the same way in all clones tested ( Figure 7C ).	./cache/cord-011630-lfm34fsw.txt	./txt/cord-011630-lfm34fsw.txt