id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010784-khvrklqt	Waki, Kayoko	Integrity of plasma DNA is inversely correlated with vaccine-induced antitumor immunity in ovarian cancer patients	2020-05-11		.txt	text/plain	3076	173	50	Here, we investigated the potential utility of the circulating cell-free DNA (cfDNA) integrity—a ratio of necrotic cell-derived, longer DNA fragments versus apoptotic cell-derived shorter fragments of Alu gene—as a biomarker of vaccine therapy for patients with ovarian cancer. We analyzed plasma samples from 39 patients with advanced or recurrent ovarian cancer enrolled in clinical trials for personalized peptide vaccinations. We conducted the present study to investigate the possibility of using the circulating cfDNA integrity as a biomarker of vaccine therapy for patients with ovarian cancer. Frozen plasma samples from 39 patients with advanced or recurrent ovarian cancer who were enrolled in clinical trials of the personalized peptide vaccination during the period from January 2009 to July 2012 were used in this study [6] . We analyzed the circulating cfDNA integrity of 39 patients with advanced or recurrent ovarian cancer who were treated with a personalized peptide vaccination in a clinical trial [6] .	./cache/cord-010784-khvrklqt.txt	./txt/cord-010784-khvrklqt.txt