id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010511-eoc0ex3i	Yousefi, Shida	In vivo evidence for extracellular DNA trap formation	2020-04-30		.txt	text/plain	9212	461	32	The formation of extracellular DNA traps by neutrophils, eosinophils, and basophils, but also lymphocytes, has been observed in various infections of humans, mice, and additional species. The circulating autoantibodies such as anti-damaged-DNA/RNA ribonucleoprotein antibody immune complexes (RNP-ICs-Ab) can further activate neutrophils, including NET formation (not shown) 13, 73, 74 , leading to vicious cycle of chronic inflammation in genetically susceptible individuals 68, 74 , causing autoimmune diseases such as systemic lupus erythematous (SLE). Upon stimulation with antimicrobial 72 or antiribonucleoprotein (RNP) antibodies 13, 73, 74 , neutrophils from SLE patients have been shown to release self-DNA associated with antimicrobial peptides able to trigger innate plasmocytoid dendritic cell (pDC) activation via TLR9 to produce IFN-Ι (Fig. 1) . Deep vein thrombosis (DVT) has been linked to neutrophil activation and release of NETs based on studies investigating the pathogenic role of NETs in the pathogenesis of venous thromboembolism (VT) using genetically modified mice, various large animal models and human material assessing plasma markers or thrombi species 126 .	./cache/cord-010511-eoc0ex3i.txt	./txt/cord-010511-eoc0ex3i.txt